id sid tid token lemma pos cord-010119-t1x9gknd 1 1 key key NN cord-010119-t1x9gknd 1 2 : : : cord-010119-t1x9gknd 1 3 cord-010119-t1x9gknd cord-010119-t1x9gknd NNP cord-010119-t1x9gknd 1 4 authors author NNS cord-010119-t1x9gknd 1 5 : : : cord-010119-t1x9gknd 2 1 nan nan NNP cord-010119-t1x9gknd 2 2 title title NN cord-010119-t1x9gknd 2 3 : : : cord-010119-t1x9gknd 2 4 Abstract Abstract NNP cord-010119-t1x9gknd 2 5 Presentations Presentations NNPS cord-010119-t1x9gknd 2 6 from from IN cord-010119-t1x9gknd 2 7 the the DT cord-010119-t1x9gknd 2 8 AABB AABB NNP cord-010119-t1x9gknd 2 9 Annual Annual NNP cord-010119-t1x9gknd 2 10 Meeting Meeting NNP cord-010119-t1x9gknd 2 11 San San NNP cord-010119-t1x9gknd 2 12 Diego Diego NNP cord-010119-t1x9gknd 2 13 , , , cord-010119-t1x9gknd 2 14 CA CA NNP cord-010119-t1x9gknd 2 15 ctober ctober NNP cord-010119-t1x9gknd 2 16 7‐10 7‐10 CD cord-010119-t1x9gknd 2 17 , , , cord-010119-t1x9gknd 2 18 2017 2017 CD cord-010119-t1x9gknd 2 19 date date NN cord-010119-t1x9gknd 2 20 : : : cord-010119-t1x9gknd 2 21 2017 2017 CD cord-010119-t1x9gknd 2 22 - - HYPH cord-010119-t1x9gknd 2 23 09 09 CD cord-010119-t1x9gknd 2 24 - - HYPH cord-010119-t1x9gknd 2 25 04 04 CD cord-010119-t1x9gknd 2 26 journal journal NN cord-010119-t1x9gknd 2 27 : : : cord-010119-t1x9gknd 3 1 Transfusion transfusion NN cord-010119-t1x9gknd 3 2 DOI doi NN cord-010119-t1x9gknd 3 3 : : : cord-010119-t1x9gknd 4 1 10.1111 10.1111 CD cord-010119-t1x9gknd 4 2 / / SYM cord-010119-t1x9gknd 4 3 trf.14286 trf.14286 CD cord-010119-t1x9gknd 4 4 sha sha NNP cord-010119-t1x9gknd 4 5 : : : cord-010119-t1x9gknd 4 6 e3b74d02ad582540a4afc22af36380781e20fb8f e3b74d02ad582540a4afc22af36380781e20fb8f CD cord-010119-t1x9gknd 4 7 doc_id doc_id CD cord-010119-t1x9gknd 5 1 : : : cord-010119-t1x9gknd 5 2 10119 10119 CD cord-010119-t1x9gknd 5 3 cord_uid cord_uid NNS cord-010119-t1x9gknd 5 4 : : : cord-010119-t1x9gknd 6 1 t1x9gknd t1x9gknd NFP cord-010119-t1x9gknd 6 2 nan nan NNP cord-010119-t1x9gknd 6 3 Background Background NNP cord-010119-t1x9gknd 6 4 / / SYM cord-010119-t1x9gknd 6 5 Case Case NNP cord-010119-t1x9gknd 6 6 Studies Studies NNPS cord-010119-t1x9gknd 6 7 : : : cord-010119-t1x9gknd 7 1 Zika Zika NNP cord-010119-t1x9gknd 7 2 virus virus NN cord-010119-t1x9gknd 7 3 ( ( -LRB- cord-010119-t1x9gknd 7 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 7 5 ) ) -RRB- cord-010119-t1x9gknd 7 6 is be VBZ cord-010119-t1x9gknd 7 7 associated associate VBN cord-010119-t1x9gknd 7 8 with with IN cord-010119-t1x9gknd 7 9 severe severe JJ cord-010119-t1x9gknd 7 10 neurological neurological JJ cord-010119-t1x9gknd 7 11 consequences consequence NNS cord-010119-t1x9gknd 7 12 in in IN cord-010119-t1x9gknd 7 13 fetuses fetus NNS cord-010119-t1x9gknd 7 14 and and CC cord-010119-t1x9gknd 7 15 adults adult NNS cord-010119-t1x9gknd 7 16 and and CC cord-010119-t1x9gknd 7 17 potential potential NN cord-010119-t1x9gknd 7 18 for for IN cord-010119-t1x9gknd 7 19 transfusion transfusion NN cord-010119-t1x9gknd 7 20 transmission transmission NN cord-010119-t1x9gknd 7 21 ( ( -LRB- cord-010119-t1x9gknd 7 22 TT TT NNP cord-010119-t1x9gknd 7 23 ) ) -RRB- cord-010119-t1x9gknd 7 24 . . . cord-010119-t1x9gknd 8 1 RNA RNA NNP cord-010119-t1x9gknd 8 2 persistence persistence NN cord-010119-t1x9gknd 8 3 has have VBZ cord-010119-t1x9gknd 8 4 been be VBN cord-010119-t1x9gknd 8 5 reported report VBN cord-010119-t1x9gknd 8 6 in in IN cord-010119-t1x9gknd 8 7 whole whole JJ cord-010119-t1x9gknd 8 8 blood blood NN cord-010119-t1x9gknd 8 9 ( ( -LRB- cord-010119-t1x9gknd 8 10 WB WB NNP cord-010119-t1x9gknd 8 11 ) ) -RRB- cord-010119-t1x9gknd 8 12 long long RB cord-010119-t1x9gknd 8 13 after after IN cord-010119-t1x9gknd 8 14 clearance clearance NN cord-010119-t1x9gknd 8 15 of of IN cord-010119-t1x9gknd 8 16 viremia viremia NN cord-010119-t1x9gknd 8 17 in in IN cord-010119-t1x9gknd 8 18 plasma plasma NN cord-010119-t1x9gknd 8 19 , , , cord-010119-t1x9gknd 8 20 raising raise VBG cord-010119-t1x9gknd 8 21 concerns concern NNS cord-010119-t1x9gknd 8 22 over over IN cord-010119-t1x9gknd 8 23 the the DT cord-010119-t1x9gknd 8 24 risk risk NN cord-010119-t1x9gknd 8 25 of of IN cord-010119-t1x9gknd 8 26 TT TT NNP cord-010119-t1x9gknd 8 27 with with IN cord-010119-t1x9gknd 8 28 plasma plasma NN cord-010119-t1x9gknd 8 29 based base VBN cord-010119-t1x9gknd 8 30 nucleic nucleic NNS cord-010119-t1x9gknd 8 31 - - HYPH cord-010119-t1x9gknd 8 32 acid acid NN cord-010119-t1x9gknd 8 33 amplification amplification NN cord-010119-t1x9gknd 8 34 testing testing NN cord-010119-t1x9gknd 8 35 ( ( -LRB- cord-010119-t1x9gknd 8 36 NAT NAT NNP cord-010119-t1x9gknd 8 37 ) ) -RRB- cord-010119-t1x9gknd 8 38 . . . cord-010119-t1x9gknd 9 1 The the DT cord-010119-t1x9gknd 9 2 dynamics dynamic NNS cord-010119-t1x9gknd 9 3 of of IN cord-010119-t1x9gknd 9 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 9 5 persistence persistence NN cord-010119-t1x9gknd 9 6 in in IN cord-010119-t1x9gknd 9 7 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 9 8 infection infection NN cord-010119-t1x9gknd 9 9 are be VBP cord-010119-t1x9gknd 9 10 not not RB cord-010119-t1x9gknd 9 11 well well RB cord-010119-t1x9gknd 9 12 understood understand VBN cord-010119-t1x9gknd 9 13 and and CC cord-010119-t1x9gknd 9 14 are be VBP cord-010119-t1x9gknd 9 15 needed need VBN cord-010119-t1x9gknd 9 16 for for IN cord-010119-t1x9gknd 9 17 understanding understanding NN cord-010119-t1x9gknd 9 18 of of IN cord-010119-t1x9gknd 9 19 the the DT cord-010119-t1x9gknd 9 20 natural natural JJ cord-010119-t1x9gknd 9 21 history history NN cord-010119-t1x9gknd 9 22 of of IN cord-010119-t1x9gknd 9 23 ZIKV ZIKV NNP cord-010119-t1x9gknd 9 24 infection infection NN cord-010119-t1x9gknd 9 25 . . . cord-010119-t1x9gknd 10 1 We -PRON- PRP cord-010119-t1x9gknd 10 2 sought seek VBD cord-010119-t1x9gknd 10 3 to to TO cord-010119-t1x9gknd 10 4 characterize characterize VB cord-010119-t1x9gknd 10 5 the the DT cord-010119-t1x9gknd 10 6 dynamics dynamic NNS cord-010119-t1x9gknd 10 7 of of IN cord-010119-t1x9gknd 10 8 infection infection NN cord-010119-t1x9gknd 10 9 through through IN cord-010119-t1x9gknd 10 10 prospective prospective JJ cord-010119-t1x9gknd 10 11 enrollment enrollment NN cord-010119-t1x9gknd 10 12 of of IN cord-010119-t1x9gknd 10 13 ZIKV ZIKV NNP cord-010119-t1x9gknd 10 14 RNA1 RNA1 NNP cord-010119-t1x9gknd 10 15 blood blood NN cord-010119-t1x9gknd 10 16 donors donor NNS cord-010119-t1x9gknd 10 17 . . . cord-010119-t1x9gknd 11 1 Study Study NNP cord-010119-t1x9gknd 11 2 Design Design NNP cord-010119-t1x9gknd 11 3 / / SYM cord-010119-t1x9gknd 11 4 Method method NN cord-010119-t1x9gknd 11 5 : : : cord-010119-t1x9gknd 12 1 Donors donor NNS cord-010119-t1x9gknd 12 2 identified identify VBN cord-010119-t1x9gknd 12 3 through through IN cord-010119-t1x9gknd 12 4 investigational investigational JJ cord-010119-t1x9gknd 12 5 ZIKV ZIKV NNP cord-010119-t1x9gknd 12 6 NAT NAT NNP cord-010119-t1x9gknd 12 7 screening screening NN cord-010119-t1x9gknd 12 8 were be VBD cord-010119-t1x9gknd 12 9 enrolled enrol VBN cord-010119-t1x9gknd 12 10 into into IN cord-010119-t1x9gknd 12 11 longitudinal longitudinal JJ cord-010119-t1x9gknd 12 12 follow follow NN cord-010119-t1x9gknd 12 13 up up RP cord-010119-t1x9gknd 12 14 and and CC cord-010119-t1x9gknd 12 15 assessed assess VBN cord-010119-t1x9gknd 12 16 for for IN cord-010119-t1x9gknd 12 17 viral viral JJ cord-010119-t1x9gknd 12 18 and and CC cord-010119-t1x9gknd 12 19 serological serological JJ cord-010119-t1x9gknd 12 20 persistence persistence NN cord-010119-t1x9gknd 12 21 and and CC cord-010119-t1x9gknd 12 22 clinical clinical JJ cord-010119-t1x9gknd 12 23 outcomes outcome NNS cord-010119-t1x9gknd 12 24 . . . cord-010119-t1x9gknd 13 1 Plasma Plasma NNP cord-010119-t1x9gknd 13 2 and and CC cord-010119-t1x9gknd 13 3 RBC RBC NNP cord-010119-t1x9gknd 13 4 were be VBD cord-010119-t1x9gknd 13 5 obtained obtain VBN cord-010119-t1x9gknd 13 6 from from IN cord-010119-t1x9gknd 13 7 index index NN cord-010119-t1x9gknd 13 8 donations donation NNS cord-010119-t1x9gknd 13 9 and and CC cord-010119-t1x9gknd 13 10 blood blood NN cord-010119-t1x9gknd 13 11 , , , cord-010119-t1x9gknd 13 12 urine urine NN cord-010119-t1x9gknd 13 13 , , , cord-010119-t1x9gknd 13 14 saliva saliva NN cord-010119-t1x9gknd 13 15 and and CC cord-010119-t1x9gknd 13 16 semen semen NN cord-010119-t1x9gknd 13 17 samples sample NNS cord-010119-t1x9gknd 13 18 were be VBD cord-010119-t1x9gknd 13 19 collected collect VBN cord-010119-t1x9gknd 13 20 prospectively prospectively RB cord-010119-t1x9gknd 13 21 at at IN cord-010119-t1x9gknd 13 22 weeks week NNS cord-010119-t1x9gknd 13 23 1 1 CD cord-010119-t1x9gknd 13 24 , , , cord-010119-t1x9gknd 13 25 3 3 CD cord-010119-t1x9gknd 13 26 , , , cord-010119-t1x9gknd 13 27 6 6 CD cord-010119-t1x9gknd 13 28 , , , cord-010119-t1x9gknd 13 29 12 12 CD cord-010119-t1x9gknd 13 30 and and CC cord-010119-t1x9gknd 13 31 24 24 CD cord-010119-t1x9gknd 13 32 following follow VBG cord-010119-t1x9gknd 13 33 index index NN cord-010119-t1x9gknd 13 34 donations donation NNS cord-010119-t1x9gknd 13 35 from from IN cord-010119-t1x9gknd 13 36 50 50 CD cord-010119-t1x9gknd 13 37 donors donor NNS cord-010119-t1x9gknd 13 38 and and CC cord-010119-t1x9gknd 13 39 detailed detailed JJ cord-010119-t1x9gknd 13 40 symptom symptom NN cord-010119-t1x9gknd 13 41 questionnaires questionnaire NNS cord-010119-t1x9gknd 13 42 were be VBD cord-010119-t1x9gknd 13 43 administered administer VBN cord-010119-t1x9gknd 13 44 at at IN cord-010119-t1x9gknd 13 45 each each DT cord-010119-t1x9gknd 13 46 study study NN cord-010119-t1x9gknd 13 47 visit visit NN cord-010119-t1x9gknd 13 48 . . . cord-010119-t1x9gknd 14 1 Blood blood NN cord-010119-t1x9gknd 14 2 compartments compartment NNS cord-010119-t1x9gknd 14 3 and and CC cord-010119-t1x9gknd 14 4 body body NN cord-010119-t1x9gknd 14 5 fluids fluid NNS cord-010119-t1x9gknd 14 6 were be VBD cord-010119-t1x9gknd 14 7 tested test VBN cord-010119-t1x9gknd 14 8 for for IN cord-010119-t1x9gknd 14 9 Zika Zika NNP cord-010119-t1x9gknd 14 10 RNA RNA NNP cord-010119-t1x9gknd 14 11 by by IN cord-010119-t1x9gknd 14 12 real real JJ cord-010119-t1x9gknd 14 13 time time NN cord-010119-t1x9gknd 14 14 RT RT NNP cord-010119-t1x9gknd 14 15 - - HYPH cord-010119-t1x9gknd 14 16 PCR PCR NNP cord-010119-t1x9gknd 14 17 . . . cord-010119-t1x9gknd 15 1 Plasma plasma NN cord-010119-t1x9gknd 15 2 samples sample NNS cord-010119-t1x9gknd 15 3 were be VBD cord-010119-t1x9gknd 15 4 tested test VBN cord-010119-t1x9gknd 15 5 for for IN cord-010119-t1x9gknd 15 6 Zika Zika NNP cord-010119-t1x9gknd 15 7 specific specific JJ cord-010119-t1x9gknd 15 8 IgM IgM NNP cord-010119-t1x9gknd 15 9 and and CC cord-010119-t1x9gknd 15 10 IgG IgG NNP cord-010119-t1x9gknd 15 11 antibodies antibody NNS cord-010119-t1x9gknd 16 1 Results result NNS cord-010119-t1x9gknd 16 2 / / SYM cord-010119-t1x9gknd 16 3 Finding finding NN cord-010119-t1x9gknd 16 4 : : : cord-010119-t1x9gknd 17 1 The the DT cord-010119-t1x9gknd 17 2 percent percent NN cord-010119-t1x9gknd 17 3 of of IN cord-010119-t1x9gknd 17 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 17 5 RNA1 RNA1 NNP cord-010119-t1x9gknd 17 6 samples sample NNS cord-010119-t1x9gknd 17 7 , , , cord-010119-t1x9gknd 17 8 followed follow VBN cord-010119-t1x9gknd 17 9 by by IN cord-010119-t1x9gknd 17 10 the the DT cord-010119-t1x9gknd 17 11 number number NN cord-010119-t1x9gknd 17 12 of of IN cord-010119-t1x9gknd 17 13 samples sample NNS cord-010119-t1x9gknd 17 14 tested test VBN cord-010119-t1x9gknd 17 15 in in IN cord-010119-t1x9gknd 17 16 parenthesis parenthesis NN cord-010119-t1x9gknd 17 17 , , , cord-010119-t1x9gknd 17 18 for for IN cord-010119-t1x9gknd 17 19 each each DT cord-010119-t1x9gknd 17 20 sample sample NN cord-010119-t1x9gknd 17 21 type type NN cord-010119-t1x9gknd 17 22 during during IN cord-010119-t1x9gknd 17 23 each each DT cord-010119-t1x9gknd 17 24 sampling sampling NN cord-010119-t1x9gknd 17 25 interval interval NN cord-010119-t1x9gknd 17 26 is be VBZ cord-010119-t1x9gknd 17 27 summarized summarize VBN cord-010119-t1x9gknd 17 28 in in IN cord-010119-t1x9gknd 17 29 the the DT cord-010119-t1x9gknd 17 30 table table NN cord-010119-t1x9gknd 17 31 . . . cord-010119-t1x9gknd 18 1 Plasma plasma NN cord-010119-t1x9gknd 18 2 viremia viremia NN cord-010119-t1x9gknd 18 3 declined decline VBD cord-010119-t1x9gknd 18 4 rapidly rapidly RB cord-010119-t1x9gknd 18 5 after after IN cord-010119-t1x9gknd 18 6 index index NN cord-010119-t1x9gknd 18 7 donations donation NNS cord-010119-t1x9gknd 18 8 whereas whereas IN cord-010119-t1x9gknd 18 9 RBC RBC NNP cord-010119-t1x9gknd 18 10 - - HYPH cord-010119-t1x9gknd 18 11 and and CC cord-010119-t1x9gknd 18 12 WB WB NNP cord-010119-t1x9gknd 18 13 - - HYPH cord-010119-t1x9gknd 18 14 associated associate VBN cord-010119-t1x9gknd 18 15 viral viral JJ cord-010119-t1x9gknd 18 16 RNA RNA NNP cord-010119-t1x9gknd 18 17 persisted persist VBD cord-010119-t1x9gknd 18 18 for for IN cord-010119-t1x9gknd 18 19 up up IN cord-010119-t1x9gknd 18 20 to to TO cord-010119-t1x9gknd 18 21 3 3 CD cord-010119-t1x9gknd 18 22 months month NNS cord-010119-t1x9gknd 18 23 and and CC cord-010119-t1x9gknd 18 24 peripheral peripheral JJ cord-010119-t1x9gknd 18 25 blood blood NN cord-010119-t1x9gknd 18 26 mononuclear mononuclear JJ cord-010119-t1x9gknd 18 27 cell cell NN cord-010119-t1x9gknd 18 28 ( ( -LRB- cord-010119-t1x9gknd 18 29 PBMC PBMC NNP cord-010119-t1x9gknd 18 30 ) ) -RRB- cord-010119-t1x9gknd 19 1 associated associate VBN cord-010119-t1x9gknd 19 2 virus virus NN cord-010119-t1x9gknd 19 3 was be VBD cord-010119-t1x9gknd 19 4 detected detect VBN cord-010119-t1x9gknd 19 5 intermittently intermittently RB cord-010119-t1x9gknd 19 6 at at IN cord-010119-t1x9gknd 19 7 low low JJ cord-010119-t1x9gknd 19 8 levels level NNS cord-010119-t1x9gknd 19 9 and and CC cord-010119-t1x9gknd 19 10 waning wane VBG cord-010119-t1x9gknd 19 11 by by IN cord-010119-t1x9gknd 19 12 3 3 CD cord-010119-t1x9gknd 19 13 months month NNS cord-010119-t1x9gknd 19 14 . . . cord-010119-t1x9gknd 20 1 Urine urine NN cord-010119-t1x9gknd 20 2 and and CC cord-010119-t1x9gknd 20 3 saliva saliva NN cord-010119-t1x9gknd 20 4 detection detection NN cord-010119-t1x9gknd 20 5 decreased decrease VBD cord-010119-t1x9gknd 20 6 significantly significantly RB cord-010119-t1x9gknd 20 7 after after IN cord-010119-t1x9gknd 20 8 2 2 CD cord-010119-t1x9gknd 20 9 weeks week NNS cord-010119-t1x9gknd 20 10 and and CC cord-010119-t1x9gknd 20 11 was be VBD cord-010119-t1x9gknd 20 12 undetectable undetectable JJ cord-010119-t1x9gknd 20 13 by by IN cord-010119-t1x9gknd 20 14 3 3 CD cord-010119-t1x9gknd 20 15 months month NNS cord-010119-t1x9gknd 20 16 . . . cord-010119-t1x9gknd 21 1 Of of IN cord-010119-t1x9gknd 21 2 donors donor NNS cord-010119-t1x9gknd 21 3 who who WP cord-010119-t1x9gknd 21 4 were be VBD cord-010119-t1x9gknd 21 5 enrolled enrol VBN cord-010119-t1x9gknd 21 6 in in IN cord-010119-t1x9gknd 21 7 the the DT cord-010119-t1x9gknd 21 8 acute acute JJ cord-010119-t1x9gknd 21 9 pre pre JJ cord-010119-t1x9gknd 21 10 - - JJ cord-010119-t1x9gknd 21 11 seroconversion seroconversion JJ cord-010119-t1x9gknd 21 12 stage stage NN cord-010119-t1x9gknd 21 13 of of IN cord-010119-t1x9gknd 21 14 infection infection NN cord-010119-t1x9gknd 21 15 65 65 CD cord-010119-t1x9gknd 21 16 % % NN cord-010119-t1x9gknd 21 17 ( ( -LRB- cord-010119-t1x9gknd 21 18 15/23 15/23 CD cord-010119-t1x9gknd 21 19 ) ) -RRB- cord-010119-t1x9gknd 21 20 developed develop VBD cord-010119-t1x9gknd 21 21 multiple multiple JJ cord-010119-t1x9gknd 21 22 ZIKV ZIKV NNP cord-010119-t1x9gknd 21 23 related relate VBN cord-010119-t1x9gknd 21 24 symptoms symptom NNS cord-010119-t1x9gknd 21 25 1 1 CD cord-010119-t1x9gknd 21 26 week week NN cord-010119-t1x9gknd 21 27 post post NN cord-010119-t1x9gknd 21 28 index index NN cord-010119-t1x9gknd 21 29 donation donation NN cord-010119-t1x9gknd 21 30 , , , cord-010119-t1x9gknd 21 31 compared compare VBN cord-010119-t1x9gknd 21 32 to to IN cord-010119-t1x9gknd 21 33 only only RB cord-010119-t1x9gknd 21 34 30 30 CD cord-010119-t1x9gknd 21 35 % % NN cord-010119-t1x9gknd 21 36 ( ( -LRB- cord-010119-t1x9gknd 21 37 7/27 7/27 CD cord-010119-t1x9gknd 21 38 ) ) -RRB- cord-010119-t1x9gknd 21 39 for for IN cord-010119-t1x9gknd 21 40 donors donor NNS cord-010119-t1x9gknd 21 41 detected detect VBD cord-010119-t1x9gknd 21 42 post post JJ cord-010119-t1x9gknd 21 43 - - NN cord-010119-t1x9gknd 21 44 seroconversion seroconversion NN cord-010119-t1x9gknd 21 45 . . . cord-010119-t1x9gknd 22 1 Conclusion conclusion NN cord-010119-t1x9gknd 22 2 : : : cord-010119-t1x9gknd 23 1 ZIKV ZIKV NNP cord-010119-t1x9gknd 23 2 RNA RNA NNP cord-010119-t1x9gknd 23 3 persists persist VBZ cord-010119-t1x9gknd 23 4 in in IN cord-010119-t1x9gknd 23 5 cellular cellular JJ cord-010119-t1x9gknd 23 6 blood blood NN cord-010119-t1x9gknd 23 7 compartments compartment NNS cord-010119-t1x9gknd 23 8 for for IN cord-010119-t1x9gknd 23 9 several several JJ cord-010119-t1x9gknd 23 10 months month NNS cord-010119-t1x9gknd 23 11 following follow VBG cord-010119-t1x9gknd 23 12 clearance clearance NN cord-010119-t1x9gknd 23 13 from from IN cord-010119-t1x9gknd 23 14 plasma plasma NN cord-010119-t1x9gknd 23 15 and and CC cord-010119-t1x9gknd 23 16 body body NN cord-010119-t1x9gknd 23 17 fluids fluid NNS cord-010119-t1x9gknd 23 18 , , , cord-010119-t1x9gknd 23 19 with with IN cord-010119-t1x9gknd 23 20 higher high JJR cord-010119-t1x9gknd 23 21 rates rate NNS cord-010119-t1x9gknd 23 22 of of IN cord-010119-t1x9gknd 23 23 symptoms symptom NNS cord-010119-t1x9gknd 23 24 than than IN cord-010119-t1x9gknd 23 25 previously previously RB cord-010119-t1x9gknd 23 26 reported report VBN cord-010119-t1x9gknd 23 27 . . . cord-010119-t1x9gknd 24 1 The the DT cord-010119-t1x9gknd 24 2 persistence persistence NN cord-010119-t1x9gknd 24 3 of of IN cord-010119-t1x9gknd 24 4 Zika Zika NNP cord-010119-t1x9gknd 24 5 RNA RNA NNP cord-010119-t1x9gknd 24 6 in in IN cord-010119-t1x9gknd 24 7 RBCs rbc NNS cord-010119-t1x9gknd 24 8 has have VBZ cord-010119-t1x9gknd 24 9 unknown unknown JJ cord-010119-t1x9gknd 24 10 implications implication NNS cord-010119-t1x9gknd 24 11 for for IN cord-010119-t1x9gknd 24 12 blood blood NN cord-010119-t1x9gknd 24 13 screening screening NN cord-010119-t1x9gknd 24 14 , , , cord-010119-t1x9gknd 24 15 which which WDT cord-010119-t1x9gknd 24 16 currently currently RB cord-010119-t1x9gknd 24 17 relies rely VBZ cord-010119-t1x9gknd 24 18 on on IN cord-010119-t1x9gknd 24 19 plasma plasma NN cord-010119-t1x9gknd 24 20 testing testing NN cord-010119-t1x9gknd 24 21 ; ; : cord-010119-t1x9gknd 24 22 infectivity infectivity NN cord-010119-t1x9gknd 24 23 studies study NNS cord-010119-t1x9gknd 24 24 are be VBP cord-010119-t1x9gknd 24 25 in in IN cord-010119-t1x9gknd 24 26 progress progress NN cord-010119-t1x9gknd 24 27 . . . cord-010119-t1x9gknd 25 1 WB WB NNP cord-010119-t1x9gknd 25 2 testing testing NN cord-010119-t1x9gknd 25 3 may may MD cord-010119-t1x9gknd 25 4 be be VB cord-010119-t1x9gknd 25 5 of of IN cord-010119-t1x9gknd 25 6 value value NN cord-010119-t1x9gknd 25 7 to to TO cord-010119-t1x9gknd 25 8 extend extend VB cord-010119-t1x9gknd 25 9 detection detection NN cord-010119-t1x9gknd 25 10 of of IN cord-010119-t1x9gknd 25 11 acute acute JJ cord-010119-t1x9gknd 25 12 infection infection NN cord-010119-t1x9gknd 25 13 and and CC cord-010119-t1x9gknd 25 14 for for IN cord-010119-t1x9gknd 25 15 diagnostics diagnostic NNS cord-010119-t1x9gknd 25 16 and and CC cord-010119-t1x9gknd 25 17 monitoring monitoring NN cord-010119-t1x9gknd 25 18 of of IN cord-010119-t1x9gknd 25 19 pregnant pregnant JJ cord-010119-t1x9gknd 25 20 women woman NNS cord-010119-t1x9gknd 25 21 . . . cord-010119-t1x9gknd 26 1 Iron iron NN cord-010119-t1x9gknd 26 2 Status Status NNP cord-010119-t1x9gknd 26 3 and and CC cord-010119-t1x9gknd 26 4 Novel Novel NNP cord-010119-t1x9gknd 26 5 Risk Risk NNP cord-010119-t1x9gknd 26 6 Factors Factors NNP cord-010119-t1x9gknd 26 7 for for IN cord-010119-t1x9gknd 26 8 Iron Iron NNP cord-010119-t1x9gknd 26 9 Depletion Depletion NNP cord-010119-t1x9gknd 26 10 in in IN cord-010119-t1x9gknd 26 11 a a DT cord-010119-t1x9gknd 26 12 Diverse Diverse NNP cord-010119-t1x9gknd 26 13 Donor Donor NNP cord-010119-t1x9gknd 26 14 Population Population NNP cord-010119-t1x9gknd 26 15 Bryan Bryan NNP cord-010119-t1x9gknd 26 16 R. R. NNP cord-010119-t1x9gknd 26 17 Spencer Spencer NNP cord-010119-t1x9gknd 26 18 * * NFP cord-010119-t1x9gknd 26 19 1 1 CD cord-010119-t1x9gknd 26 20 , , , cord-010119-t1x9gknd 26 21 Yuelong Yuelong NNP cord-010119-t1x9gknd 26 22 Guo Guo NNP cord-010119-t1x9gknd 26 23 2 2 CD cord-010119-t1x9gknd 26 24 , , , cord-010119-t1x9gknd 26 25 Ritchard Ritchard NNP cord-010119-t1x9gknd 26 26 G. G. NNP cord-010119-t1x9gknd 26 27 Cable Cable NNP cord-010119-t1x9gknd 26 28 3 3 CD cord-010119-t1x9gknd 26 29 , , , cord-010119-t1x9gknd 26 30 Joseph Joseph NNP cord-010119-t1x9gknd 26 31 E. E. NNP cord-010119-t1x9gknd 26 32 Kiss Kiss NNP cord-010119-t1x9gknd 26 33 4 4 CD cord-010119-t1x9gknd 26 34 , , , cord-010119-t1x9gknd 26 35 Michael Michael NNP cord-010119-t1x9gknd 26 36 Paul Paul NNP cord-010119-t1x9gknd 26 37 Busch Busch NNP cord-010119-t1x9gknd 26 38 5 5 CD cord-010119-t1x9gknd 26 39 , , , cord-010119-t1x9gknd 26 40 Grier Grier NNP cord-010119-t1x9gknd 26 41 Page Page NNP cord-010119-t1x9gknd 26 42 2 2 CD cord-010119-t1x9gknd 26 43 , , , cord-010119-t1x9gknd 26 44 Stacy Stacy NNP cord-010119-t1x9gknd 26 45 Endres Endres NNP cord-010119-t1x9gknd 26 46 - - HYPH cord-010119-t1x9gknd 26 47 Dighe Dighe NNP cord-010119-t1x9gknd 26 48 2 2 CD cord-010119-t1x9gknd 26 49 , , , cord-010119-t1x9gknd 26 50 Steve Steve NNP cord-010119-t1x9gknd 26 51 Kleinman Kleinman NNP cord-010119-t1x9gknd 26 52 6 6 CD cord-010119-t1x9gknd 26 53 , , , cord-010119-t1x9gknd 26 54 Simone Simone NNP cord-010119-t1x9gknd 26 55 Glynn Glynn NNP cord-010119-t1x9gknd 26 56 7 7 CD cord-010119-t1x9gknd 26 57 , , , cord-010119-t1x9gknd 26 58 Alan Alan NNP cord-010119-t1x9gknd 26 59 Mast Mast NNP cord-010119-t1x9gknd 26 60 8 8 CD cord-010119-t1x9gknd 26 61 and and CC cord-010119-t1x9gknd 26 62 for for IN cord-010119-t1x9gknd 26 63 the the DT cord-010119-t1x9gknd 26 64 NHLBI NHLBI NNP cord-010119-t1x9gknd 27 1 Recipient recipient NN cord-010119-t1x9gknd 27 2 Epidemiology Epidemiology NNP cord-010119-t1x9gknd 27 3 and and CC cord-010119-t1x9gknd 27 4 Donor Donor NNP cord-010119-t1x9gknd 27 5 Evaluation Evaluation NNP cord-010119-t1x9gknd 27 6 Study Study NNP cord-010119-t1x9gknd 27 7 - - HYPH cord-010119-t1x9gknd 27 8 III III NNP cord-010119-t1x9gknd 27 9 ( ( -LRB- cord-010119-t1x9gknd 27 10 REDS REDS NNP cord-010119-t1x9gknd 27 11 - - HYPH cord-010119-t1x9gknd 27 12 III III NNP cord-010119-t1x9gknd 27 13 ) ) -RRB- cord-010119-t1x9gknd 27 14 9 9 CD cord-010119-t1x9gknd 27 15 . . . cord-010119-t1x9gknd 27 16 1 1 CD cord-010119-t1x9gknd 27 17 American American NNP cord-010119-t1x9gknd 27 18 Red Red NNP cord-010119-t1x9gknd 27 19 Cross Cross NNP cord-010119-t1x9gknd 27 20 , , , cord-010119-t1x9gknd 27 21 2 2 CD cord-010119-t1x9gknd 27 22 RTI RTI NNP cord-010119-t1x9gknd 27 23 International International NNP cord-010119-t1x9gknd 27 24 , , , cord-010119-t1x9gknd 27 25 3 3 CD cord-010119-t1x9gknd 27 26 American American NNP cord-010119-t1x9gknd 27 27 Red Red NNP cord-010119-t1x9gknd 27 28 Cross Cross NNP cord-010119-t1x9gknd 27 29 Blood Blood NNP cord-010119-t1x9gknd 27 30 Services Services NNPS cord-010119-t1x9gknd 27 31 , , , cord-010119-t1x9gknd 27 32 4 4 CD cord-010119-t1x9gknd 27 33 Blood Blood NNP cord-010119-t1x9gknd 27 34 Systems Systems NNPS cord-010119-t1x9gknd 27 35 Inc. Inc. NNP cord-010119-t1x9gknd 27 36 , , , cord-010119-t1x9gknd 27 37 5 5 CD cord-010119-t1x9gknd 27 38 Blood Blood NNP cord-010119-t1x9gknd 27 39 Systems Systems NNPS cord-010119-t1x9gknd 27 40 Research Research NNP cord-010119-t1x9gknd 27 41 Institute Institute NNP cord-010119-t1x9gknd 27 42 , , , cord-010119-t1x9gknd 27 43 6 6 CD cord-010119-t1x9gknd 27 44 University University NNP cord-010119-t1x9gknd 27 45 of of IN cord-010119-t1x9gknd 27 46 British British NNP cord-010119-t1x9gknd 27 47 Columbia Columbia NNP cord-010119-t1x9gknd 27 48 , , , cord-010119-t1x9gknd 27 49 7 7 CD cord-010119-t1x9gknd 27 50 NIH/ NIH/ NNP cord-010119-t1x9gknd 27 51 NHLBI NHLBI NNP cord-010119-t1x9gknd 27 52 , , , cord-010119-t1x9gknd 27 53 8 8 CD cord-010119-t1x9gknd 27 54 Blood Blood NNP cord-010119-t1x9gknd 27 55 Research Research NNP cord-010119-t1x9gknd 27 56 Institute Institute NNP cord-010119-t1x9gknd 27 57 , , , cord-010119-t1x9gknd 27 58 9 9 CD cord-010119-t1x9gknd 27 59 NHLBI NHLBI NNP cord-010119-t1x9gknd 27 60 Background Background NNP cord-010119-t1x9gknd 27 61 / / SYM cord-010119-t1x9gknd 27 62 Case Case NNP cord-010119-t1x9gknd 27 63 Studies Studies NNPS cord-010119-t1x9gknd 27 64 : : : cord-010119-t1x9gknd 27 65 Blood blood NN cord-010119-t1x9gknd 27 66 centers center NNS cord-010119-t1x9gknd 27 67 and and CC cord-010119-t1x9gknd 27 68 regulators regulator NNS cord-010119-t1x9gknd 27 69 in in IN cord-010119-t1x9gknd 27 70 the the DT cord-010119-t1x9gknd 27 71 United United NNP cord-010119-t1x9gknd 27 72 States States NNP cord-010119-t1x9gknd 27 73 ( ( -LRB- cord-010119-t1x9gknd 27 74 US US NNP cord-010119-t1x9gknd 27 75 ) ) -RRB- cord-010119-t1x9gknd 27 76 are be VBP cord-010119-t1x9gknd 27 77 evaluating evaluate VBG cord-010119-t1x9gknd 27 78 strategies strategy NNS cord-010119-t1x9gknd 27 79 for for IN cord-010119-t1x9gknd 27 80 minimizing minimize VBG cord-010119-t1x9gknd 27 81 iron iron NN cord-010119-t1x9gknd 27 82 depletion depletion NN cord-010119-t1x9gknd 27 83 in in IN cord-010119-t1x9gknd 27 84 blood blood NN cord-010119-t1x9gknd 27 85 donors donor NNS cord-010119-t1x9gknd 27 86 . . . cord-010119-t1x9gknd 28 1 The the DT cord-010119-t1x9gknd 28 2 logistics logistic NNS cord-010119-t1x9gknd 28 3 of of IN cord-010119-t1x9gknd 28 4 donor donor NN cord-010119-t1x9gknd 28 5 management management NN cord-010119-t1x9gknd 28 6 might may MD cord-010119-t1x9gknd 28 7 differ differ VB cord-010119-t1x9gknd 28 8 across across IN cord-010119-t1x9gknd 28 9 blood blood NN cord-010119-t1x9gknd 28 10 centers center NNS cord-010119-t1x9gknd 28 11 , , , cord-010119-t1x9gknd 28 12 but but CC cord-010119-t1x9gknd 28 13 the the DT cord-010119-t1x9gknd 28 14 optimal optimal JJ cord-010119-t1x9gknd 28 15 approach approach NN cord-010119-t1x9gknd 28 16 may may MD cord-010119-t1x9gknd 28 17 also also RB cord-010119-t1x9gknd 28 18 vary vary VB cord-010119-t1x9gknd 28 19 according accord VBG cord-010119-t1x9gknd 28 20 to to IN cord-010119-t1x9gknd 28 21 biological biological JJ cord-010119-t1x9gknd 28 22 or or CC cord-010119-t1x9gknd 28 23 behavioral behavioral JJ cord-010119-t1x9gknd 28 24 differences difference NNS cord-010119-t1x9gknd 28 25 across across IN cord-010119-t1x9gknd 28 26 sub sub NN cord-010119-t1x9gknd 28 27 - - NNS cord-010119-t1x9gknd 28 28 populations population NNS cord-010119-t1x9gknd 28 29 of of IN cord-010119-t1x9gknd 28 30 donors donor NNS cord-010119-t1x9gknd 28 31 . . . cord-010119-t1x9gknd 29 1 Studies study NNS cord-010119-t1x9gknd 29 2 donors donor NNS cord-010119-t1x9gknd 29 3 have have VBP cord-010119-t1x9gknd 29 4 been be VBN cord-010119-t1x9gknd 29 5 conducted conduct VBN cord-010119-t1x9gknd 29 6 in in IN cord-010119-t1x9gknd 29 7 predominantly predominantly RB cord-010119-t1x9gknd 29 8 Caucasian caucasian JJ cord-010119-t1x9gknd 29 9 populations population NNS cord-010119-t1x9gknd 29 10 , , , cord-010119-t1x9gknd 29 11 which which WDT cord-010119-t1x9gknd 29 12 may may MD cord-010119-t1x9gknd 29 13 differ differ VB cord-010119-t1x9gknd 29 14 from from IN cord-010119-t1x9gknd 29 15 racial racial JJ cord-010119-t1x9gknd 29 16 / / SYM cord-010119-t1x9gknd 29 17 ethnic ethnic JJ cord-010119-t1x9gknd 29 18 minority minority NN cord-010119-t1x9gknd 29 19 donors donor NNS cord-010119-t1x9gknd 29 20 in in IN cord-010119-t1x9gknd 29 21 iron iron NN cord-010119-t1x9gknd 29 22 metabolism metabolism NN cord-010119-t1x9gknd 29 23 and and CC cord-010119-t1x9gknd 29 24 capacity capacity NN cord-010119-t1x9gknd 29 25 to to TO cord-010119-t1x9gknd 29 26 undergo undergo VB cord-010119-t1x9gknd 29 27 repeat repeat NN cord-010119-t1x9gknd 29 28 phlebotomy phlebotomy NN cord-010119-t1x9gknd 29 29 . . . cord-010119-t1x9gknd 30 1 Study Study NNP cord-010119-t1x9gknd 30 2 Design Design NNP cord-010119-t1x9gknd 30 3 / / SYM cord-010119-t1x9gknd 30 4 Method method NN cord-010119-t1x9gknd 30 5 : : : cord-010119-t1x9gknd 30 6 Over over IN cord-010119-t1x9gknd 30 7 12,600 12,600 CD cord-010119-t1x9gknd 30 8 donors donor NNS cord-010119-t1x9gknd 30 9 were be VBD cord-010119-t1x9gknd 30 10 enrolled enrol VBN cord-010119-t1x9gknd 30 11 from from IN cord-010119-t1x9gknd 30 12 4 4 CD cord-010119-t1x9gknd 30 13 US US NNP cord-010119-t1x9gknd 30 14 blood blood NN cord-010119-t1x9gknd 30 15 centers center NNS cord-010119-t1x9gknd 30 16 for for IN cord-010119-t1x9gknd 30 17 ferritin ferritin NN cord-010119-t1x9gknd 30 18 testing testing NN cord-010119-t1x9gknd 30 19 . . . cord-010119-t1x9gknd 31 1 The the DT cord-010119-t1x9gknd 31 2 study study NN cord-010119-t1x9gknd 31 3 population population NN cord-010119-t1x9gknd 31 4 was be VBD cord-010119-t1x9gknd 31 5 enriched enrich VBN cord-010119-t1x9gknd 31 6 for for IN cord-010119-t1x9gknd 31 7 racial racial JJ cord-010119-t1x9gknd 31 8 minorities minority NNS cord-010119-t1x9gknd 31 9 [ [ -LRB- cord-010119-t1x9gknd 31 10 1600 1600 CD cord-010119-t1x9gknd 31 11 African african JJ cord-010119-t1x9gknd 31 12 - - HYPH cord-010119-t1x9gknd 31 13 American american JJ cord-010119-t1x9gknd 31 14 ( ( -LRB- cord-010119-t1x9gknd 31 15 AA AA NNP cord-010119-t1x9gknd 31 16 ) ) -RRB- cord-010119-t1x9gknd 31 17 , , , cord-010119-t1x9gknd 31 18 1600 1600 CD cord-010119-t1x9gknd 31 19 Asian asian JJ cord-010119-t1x9gknd 31 20 ( ( -LRB- cord-010119-t1x9gknd 31 21 As as IN cord-010119-t1x9gknd 31 22 ) ) -RRB- cord-010119-t1x9gknd 31 23 , , , cord-010119-t1x9gknd 31 24 1000 1000 CD cord-010119-t1x9gknd 31 25 Hispanic hispanic JJ cord-010119-t1x9gknd 31 26 ( ( -LRB- cord-010119-t1x9gknd 31 27 Hisp Hisp NNP cord-010119-t1x9gknd 31 28 ) ) -RRB- cord-010119-t1x9gknd 31 29 ] ] -RRB- cord-010119-t1x9gknd 31 30 and and CC cord-010119-t1x9gknd 31 31 for for IN cord-010119-t1x9gknd 31 32 " " `` cord-010119-t1x9gknd 31 33 Super Super NNP cord-010119-t1x9gknd 31 34 Donors Donors NNPS cord-010119-t1x9gknd 31 35 " " '' cord-010119-t1x9gknd 31 36 ( ( -LRB- cord-010119-t1x9gknd 31 37 1600 1600 CD cord-010119-t1x9gknd 31 38 , , , cord-010119-t1x9gknd 31 39 who who WP cord-010119-t1x9gknd 31 40 had have VBD cord-010119-t1x9gknd 31 41 completed complete VBN cord-010119-t1x9gknd 31 42 101 101 CD cord-010119-t1x9gknd 31 43 donations donation NNS cord-010119-t1x9gknd 31 44 in in IN cord-010119-t1x9gknd 31 45 two two CD cord-010119-t1x9gknd 31 46 years year NNS cord-010119-t1x9gknd 31 47 without without IN cord-010119-t1x9gknd 31 48 low low JJ cord-010119-t1x9gknd 31 49 hemoglobin hemoglobin NN cord-010119-t1x9gknd 31 50 deferral deferral NN cord-010119-t1x9gknd 31 51 ) ) -RRB- cord-010119-t1x9gknd 31 52 . . . cord-010119-t1x9gknd 32 1 The the DT cord-010119-t1x9gknd 32 2 minority minority NN cord-010119-t1x9gknd 32 3 donors donor NNS cord-010119-t1x9gknd 32 4 and and CC cord-010119-t1x9gknd 32 5 the the DT cord-010119-t1x9gknd 32 6 remaining remain VBG cord-010119-t1x9gknd 32 7 6800 6800 CD cord-010119-t1x9gknd 32 8 non non JJ cord-010119-t1x9gknd 32 9 - - JJ cord-010119-t1x9gknd 32 10 Hispanic hispanic JJ cord-010119-t1x9gknd 32 11 White White NNP cord-010119-t1x9gknd 32 12 ( ( -LRB- cord-010119-t1x9gknd 32 13 NHW NHW NNP cord-010119-t1x9gknd 32 14 ) ) -RRB- cord-010119-t1x9gknd 32 15 donors donor NNS cord-010119-t1x9gknd 32 16 were be VBD cord-010119-t1x9gknd 32 17 an an DT cord-010119-t1x9gknd 32 18 unselected unselected JJ cord-010119-t1x9gknd 32 19 population population NN cord-010119-t1x9gknd 32 20 with with IN cord-010119-t1x9gknd 32 21 no no DT cord-010119-t1x9gknd 32 22 specific specific JJ cord-010119-t1x9gknd 32 23 eligibility eligibility NN cord-010119-t1x9gknd 32 24 criteria criterion NNS cord-010119-t1x9gknd 32 25 . . . cord-010119-t1x9gknd 33 1 Subjects subject NNS cord-010119-t1x9gknd 33 2 completed complete VBD cord-010119-t1x9gknd 33 3 questionnaires questionnaire NNS cord-010119-t1x9gknd 33 4 on on IN cord-010119-t1x9gknd 33 5 risk risk NN cord-010119-t1x9gknd 33 6 factors factor NNS cord-010119-t1x9gknd 33 7 for for IN cord-010119-t1x9gknd 33 8 iron iron NN cord-010119-t1x9gknd 33 9 depletion depletion NN cord-010119-t1x9gknd 33 10 . . . cord-010119-t1x9gknd 34 1 Logistic logistic JJ cord-010119-t1x9gknd 34 2 regression regression NN cord-010119-t1x9gknd 34 3 was be VBD cord-010119-t1x9gknd 34 4 used use VBN cord-010119-t1x9gknd 34 5 to to TO cord-010119-t1x9gknd 34 6 identify identify VB cord-010119-t1x9gknd 34 7 demographic demographic JJ cord-010119-t1x9gknd 34 8 and and CC cord-010119-t1x9gknd 34 9 behavioral behavioral JJ cord-010119-t1x9gknd 34 10 predictors predictor NNS cord-010119-t1x9gknd 34 11 of of IN cord-010119-t1x9gknd 34 12 Absent Absent NNP cord-010119-t1x9gknd 34 13 Iron Iron NNP cord-010119-t1x9gknd 34 14 Stores Stores NNPS cord-010119-t1x9gknd 34 15 ( ( -LRB- cord-010119-t1x9gknd 34 16 AIS AIS NNP cord-010119-t1x9gknd 34 17 , , , cord-010119-t1x9gknd 34 18 ferritin ferritin NN cord-010119-t1x9gknd 34 19 < < XX cord-010119-t1x9gknd 34 20 12 12 CD cord-010119-t1x9gknd 34 21 ng ng NNP cord-010119-t1x9gknd 34 22 / / SYM cord-010119-t1x9gknd 34 23 ml ml NN cord-010119-t1x9gknd 34 24 ) ) -RRB- cord-010119-t1x9gknd 34 25 and and CC cord-010119-t1x9gknd 34 26 Low Low NNP cord-010119-t1x9gknd 34 27 Ferritin ferritin NN cord-010119-t1x9gknd 34 28 ( ( -LRB- cord-010119-t1x9gknd 34 29 LF lf NN cord-010119-t1x9gknd 34 30 , , , cord-010119-t1x9gknd 34 31 ferritin ferritin NN cord-010119-t1x9gknd 34 32 < < XX cord-010119-t1x9gknd 34 33 26 26 CD cord-010119-t1x9gknd 34 34 ng ng NNP cord-010119-t1x9gknd 34 35 / / SYM cord-010119-t1x9gknd 34 36 ml ml NN cord-010119-t1x9gknd 34 37 ) ) -RRB- cord-010119-t1x9gknd 34 38 . . . cord-010119-t1x9gknd 35 1 Results result NNS cord-010119-t1x9gknd 35 2 / / SYM cord-010119-t1x9gknd 35 3 Findings finding NNS cord-010119-t1x9gknd 35 4 : : : cord-010119-t1x9gknd 36 1 Across across IN cord-010119-t1x9gknd 36 2 all all DT cord-010119-t1x9gknd 36 3 subjects subject NNS cord-010119-t1x9gknd 36 4 , , , cord-010119-t1x9gknd 36 5 19 19 CD cord-010119-t1x9gknd 36 6 % % NN cord-010119-t1x9gknd 36 7 had have VBD cord-010119-t1x9gknd 36 8 AIS AIS NNP cord-010119-t1x9gknd 36 9 and and CC cord-010119-t1x9gknd 36 10 42 42 CD cord-010119-t1x9gknd 36 11 % % NN cord-010119-t1x9gknd 36 12 had have VBD cord-010119-t1x9gknd 36 13 LF LF NNP cord-010119-t1x9gknd 36 14 , , , cord-010119-t1x9gknd 36 15 with with IN cord-010119-t1x9gknd 36 16 a a DT cord-010119-t1x9gknd 36 17 high high JJ cord-010119-t1x9gknd 36 18 degree degree NN cord-010119-t1x9gknd 36 19 of of IN cord-010119-t1x9gknd 36 20 variability variability NN cord-010119-t1x9gknd 36 21 based base VBN cord-010119-t1x9gknd 36 22 on on IN cord-010119-t1x9gknd 36 23 demographic demographic JJ cord-010119-t1x9gknd 36 24 factors factor NNS cord-010119-t1x9gknd 36 25 and and CC cord-010119-t1x9gknd 36 26 donation donation NN cord-010119-t1x9gknd 36 27 behavior behavior NN cord-010119-t1x9gknd 36 28 . . . cord-010119-t1x9gknd 37 1 In in IN cord-010119-t1x9gknd 37 2 models model NNS cord-010119-t1x9gknd 37 3 stratified stratify VBN cord-010119-t1x9gknd 37 4 by by IN cord-010119-t1x9gknd 37 5 race race NN cord-010119-t1x9gknd 37 6 , , , cord-010119-t1x9gknd 37 7 expected expect VBN cord-010119-t1x9gknd 37 8 patterns pattern NNS cord-010119-t1x9gknd 37 9 common common JJ cord-010119-t1x9gknd 37 10 to to IN cord-010119-t1x9gknd 37 11 all all DT cord-010119-t1x9gknd 37 12 4 4 CD cord-010119-t1x9gknd 37 13 groups group NNS cord-010119-t1x9gknd 37 14 included include VBD cord-010119-t1x9gknd 37 15 a a DT cord-010119-t1x9gknd 37 16 sharp sharp JJ cord-010119-t1x9gknd 37 17 increase increase NN cord-010119-t1x9gknd 37 18 in in IN cord-010119-t1x9gknd 37 19 risk risk NN cord-010119-t1x9gknd 37 20 with with IN cord-010119-t1x9gknd 37 21 increasing increase VBG cord-010119-t1x9gknd 37 22 donation donation NN cord-010119-t1x9gknd 37 23 intensity intensity NN cord-010119-t1x9gknd 37 24 , , , cord-010119-t1x9gknd 37 25 and and CC cord-010119-t1x9gknd 37 26 a a DT cord-010119-t1x9gknd 37 27 large large JJ cord-010119-t1x9gknd 37 28 decrement decrement NN cord-010119-t1x9gknd 37 29 in in IN cord-010119-t1x9gknd 37 30 risk risk NN cord-010119-t1x9gknd 37 31 for for IN cord-010119-t1x9gknd 37 32 females female NNS cord-010119-t1x9gknd 37 33 > > XX cord-010119-t1x9gknd 37 34 50 50 CD cord-010119-t1x9gknd 37 35 years year NNS cord-010119-t1x9gknd 37 36 old old JJ cord-010119-t1x9gknd 37 37 . . . cord-010119-t1x9gknd 38 1 In in IN cord-010119-t1x9gknd 38 2 models model NNS cord-010119-t1x9gknd 38 3 including include VBG cord-010119-t1x9gknd 38 4 all all DT cord-010119-t1x9gknd 38 5 subjects subject NNS cord-010119-t1x9gknd 38 6 , , , cord-010119-t1x9gknd 38 7 race race NN cord-010119-t1x9gknd 38 8 was be VBD cord-010119-t1x9gknd 38 9 an an DT cord-010119-t1x9gknd 38 10 independent independent JJ cord-010119-t1x9gknd 38 11 predictor predictor NN cord-010119-t1x9gknd 38 12 of of IN cord-010119-t1x9gknd 38 13 both both CC cord-010119-t1x9gknd 38 14 AIS AIS NNP cord-010119-t1x9gknd 38 15 and and CC cord-010119-t1x9gknd 38 16 LF LF NNP cord-010119-t1x9gknd 38 17 controlling control VBG cord-010119-t1x9gknd 38 18 for for IN cord-010119-t1x9gknd 38 19 age age NN cord-010119-t1x9gknd 38 20 , , , cord-010119-t1x9gknd 38 21 sex sex NN cord-010119-t1x9gknd 38 22 , , , cord-010119-t1x9gknd 38 23 body body NN cord-010119-t1x9gknd 38 24 weight weight NN cord-010119-t1x9gknd 38 25 , , , cord-010119-t1x9gknd 38 26 donation donation NN cord-010119-t1x9gknd 38 27 frequency frequency NN cord-010119-t1x9gknd 38 28 , , , cord-010119-t1x9gknd 38 29 and and CC cord-010119-t1x9gknd 38 30 other other JJ cord-010119-t1x9gknd 38 31 factors factor NNS cord-010119-t1x9gknd 38 32 ( ( -LRB- cord-010119-t1x9gknd 38 33 Table table NN cord-010119-t1x9gknd 38 34 ) ) -RRB- cord-010119-t1x9gknd 38 35 . . . cord-010119-t1x9gknd 39 1 AA AA NNP cord-010119-t1x9gknd 39 2 and and CC cord-010119-t1x9gknd 39 3 As as IN cord-010119-t1x9gknd 39 4 donors donor NNS cord-010119-t1x9gknd 39 5 showed show VBD cord-010119-t1x9gknd 39 6 % % NN cord-010119-t1x9gknd 39 7 20 20 CD cord-010119-t1x9gknd 39 8 % % NN cord-010119-t1x9gknd 39 9 decreased decrease VBD cord-010119-t1x9gknd 39 10 risk risk NN cord-010119-t1x9gknd 39 11 for for IN cord-010119-t1x9gknd 39 12 AIS AIS NNP cord-010119-t1x9gknd 39 13 compared compare VBN cord-010119-t1x9gknd 39 14 to to IN cord-010119-t1x9gknd 39 15 NHW NHW NNP cord-010119-t1x9gknd 39 16 , , , cord-010119-t1x9gknd 39 17 while while IN cord-010119-t1x9gknd 39 18 Hisp Hisp NNP cord-010119-t1x9gknd 39 19 donors donor NNS cord-010119-t1x9gknd 39 20 had have VBD cord-010119-t1x9gknd 39 21 25 25 CD cord-010119-t1x9gknd 39 22 % % NN cord-010119-t1x9gknd 39 23 higher high JJR cord-010119-t1x9gknd 39 24 risk risk NN cord-010119-t1x9gknd 39 25 . . . cord-010119-t1x9gknd 40 1 Daily daily JJ cord-010119-t1x9gknd 40 2 use use NN cord-010119-t1x9gknd 40 3 of of IN cord-010119-t1x9gknd 40 4 exogenous exogenous JJ cord-010119-t1x9gknd 40 5 iron iron NN cord-010119-t1x9gknd 40 6 reduced reduce VBN cord-010119-t1x9gknd 40 7 risk risk NN cord-010119-t1x9gknd 40 8 for for IN cord-010119-t1x9gknd 40 9 LF LF NNP cord-010119-t1x9gknd 40 10 and and CC cord-010119-t1x9gknd 40 11 AIS AIS NNP cord-010119-t1x9gknd 40 12 by by IN cord-010119-t1x9gknd 40 13 30 30 CD cord-010119-t1x9gknd 40 14 to to TO cord-010119-t1x9gknd 40 15 40 40 CD cord-010119-t1x9gknd 40 16 % % NN cord-010119-t1x9gknd 40 17 , , , cord-010119-t1x9gknd 40 18 respectively respectively RB cord-010119-t1x9gknd 40 19 , , , cord-010119-t1x9gknd 40 20 while while IN cord-010119-t1x9gknd 40 21 the the DT cord-010119-t1x9gknd 40 22 estimated estimate VBN cord-010119-t1x9gknd 40 23 benefit benefit NN cord-010119-t1x9gknd 40 24 from from IN cord-010119-t1x9gknd 40 25 less less JJR cord-010119-t1x9gknd 40 26 - - HYPH cord-010119-t1x9gknd 40 27 than than IN cord-010119-t1x9gknd 40 28 - - HYPH cord-010119-t1x9gknd 40 29 daily daily JJ cord-010119-t1x9gknd 40 30 use use NN cord-010119-t1x9gknd 40 31 was be VBD cord-010119-t1x9gknd 40 32 lower low JJR cord-010119-t1x9gknd 40 33 ( ( -LRB- cord-010119-t1x9gknd 40 34 5 5 CD cord-010119-t1x9gknd 40 35 to to TO cord-010119-t1x9gknd 40 36 19 19 CD cord-010119-t1x9gknd 40 37 % % NN cord-010119-t1x9gknd 40 38 protection protection NN cord-010119-t1x9gknd 40 39 ) ) -RRB- cord-010119-t1x9gknd 40 40 . . . cord-010119-t1x9gknd 41 1 Regular regular JJ cord-010119-t1x9gknd 41 2 use use NN cord-010119-t1x9gknd 41 3 of of IN cord-010119-t1x9gknd 41 4 antacids antacid NNS cord-010119-t1x9gknd 41 5 was be VBD cord-010119-t1x9gknd 41 6 associated associate VBN cord-010119-t1x9gknd 41 7 with with IN cord-010119-t1x9gknd 41 8 a a DT cord-010119-t1x9gknd 41 9 20 20 CD cord-010119-t1x9gknd 41 10 % % NN cord-010119-t1x9gknd 41 11 or or CC cord-010119-t1x9gknd 41 12 greater great JJR cord-010119-t1x9gknd 41 13 increment increment NN cord-010119-t1x9gknd 41 14 to to TO cord-010119-t1x9gknd 41 15 risk risk NN cord-010119-t1x9gknd 41 16 . . . cord-010119-t1x9gknd 42 1 Reported report VBN cord-010119-t1x9gknd 42 2 use use NN cord-010119-t1x9gknd 42 3 of of IN cord-010119-t1x9gknd 42 4 hormone hormone NN cord-010119-t1x9gknd 42 5 supplements supplement NNS cord-010119-t1x9gknd 42 6 showed show VBD cord-010119-t1x9gknd 42 7 opposing oppose VBG cord-010119-t1x9gknd 42 8 effects effect NNS cord-010119-t1x9gknd 42 9 in in IN cord-010119-t1x9gknd 42 10 males male NNS cord-010119-t1x9gknd 42 11 and and CC cord-010119-t1x9gknd 42 12 females female NNS cord-010119-t1x9gknd 42 13 . . . cord-010119-t1x9gknd 43 1 Use use NN cord-010119-t1x9gknd 43 2 of of IN cord-010119-t1x9gknd 43 3 oral oral JJ cord-010119-t1x9gknd 43 4 contraceptives contraceptive NNS cord-010119-t1x9gknd 43 5 or or CC cord-010119-t1x9gknd 43 6 estrogen estrogen NN cord-010119-t1x9gknd 43 7 in in IN cord-010119-t1x9gknd 43 8 females female NNS cord-010119-t1x9gknd 43 9 reduced reduce VBN cord-010119-t1x9gknd 43 10 risk risk NN cord-010119-t1x9gknd 43 11 by by IN cord-010119-t1x9gknd 43 12 % % NN cord-010119-t1x9gknd 43 13 15 15 CD cord-010119-t1x9gknd 43 14 - - SYM cord-010119-t1x9gknd 43 15 20 20 CD cord-010119-t1x9gknd 43 16 % % NN cord-010119-t1x9gknd 43 17 , , , cord-010119-t1x9gknd 43 18 while while IN cord-010119-t1x9gknd 43 19 males male NNS cord-010119-t1x9gknd 43 20 who who WP cord-010119-t1x9gknd 43 21 reported report VBD cord-010119-t1x9gknd 43 22 current current JJ cord-010119-t1x9gknd 43 23 use use NN cord-010119-t1x9gknd 43 24 of of IN cord-010119-t1x9gknd 43 25 supplemental supplemental JJ cord-010119-t1x9gknd 43 26 testosterone testosterone NN cord-010119-t1x9gknd 43 27 had have VBD cord-010119-t1x9gknd 43 28 twice twice PDT cord-010119-t1x9gknd 43 29 the the DT cord-010119-t1x9gknd 43 30 estimated estimate VBN cord-010119-t1x9gknd 43 31 risk risk NN cord-010119-t1x9gknd 43 32 for for IN cord-010119-t1x9gknd 43 33 AIS AIS NNP cord-010119-t1x9gknd 43 34 . . . cord-010119-t1x9gknd 44 1 Conclusion conclusion NN cord-010119-t1x9gknd 44 2 : : : cord-010119-t1x9gknd 45 1 This this DT cord-010119-t1x9gknd 45 2 large large JJ cord-010119-t1x9gknd 45 3 study study NN cord-010119-t1x9gknd 45 4 confirms confirm VBZ cord-010119-t1x9gknd 45 5 the the DT cord-010119-t1x9gknd 45 6 high high JJ cord-010119-t1x9gknd 45 7 prevalence prevalence NN cord-010119-t1x9gknd 45 8 of of IN cord-010119-t1x9gknd 45 9 LF lf NN cord-010119-t1x9gknd 45 10 and and CC cord-010119-t1x9gknd 45 11 AIS AIS NNP cord-010119-t1x9gknd 45 12 in in IN cord-010119-t1x9gknd 45 13 US US NNP cord-010119-t1x9gknd 45 14 donors donor NNS cord-010119-t1x9gknd 45 15 and and CC cord-010119-t1x9gknd 45 16 the the DT cord-010119-t1x9gknd 45 17 principal principal JJ cord-010119-t1x9gknd 45 18 risk risk NN cord-010119-t1x9gknd 45 19 factors factor NNS cord-010119-t1x9gknd 45 20 of of IN cord-010119-t1x9gknd 45 21 age age NN cord-010119-t1x9gknd 45 22 , , , cord-010119-t1x9gknd 45 23 sex sex NN cord-010119-t1x9gknd 45 24 , , , cord-010119-t1x9gknd 45 25 and and CC cord-010119-t1x9gknd 45 26 donation donation NN cord-010119-t1x9gknd 45 27 frequency frequency NN cord-010119-t1x9gknd 45 28 . . . cord-010119-t1x9gknd 46 1 The the DT cord-010119-t1x9gknd 46 2 diverse diverse JJ cord-010119-t1x9gknd 46 3 population population NN cord-010119-t1x9gknd 46 4 studied study VBD cord-010119-t1x9gknd 46 5 and and CC cord-010119-t1x9gknd 46 6 the the DT cord-010119-t1x9gknd 46 7 questionnaire questionnaire NN cord-010119-t1x9gknd 46 8 data datum NNS cord-010119-t1x9gknd 46 9 from from IN cord-010119-t1x9gknd 46 10 donors donor NNS cord-010119-t1x9gknd 46 11 identify identify VBP cord-010119-t1x9gknd 46 12 additional additional JJ cord-010119-t1x9gknd 46 13 demographic demographic JJ cord-010119-t1x9gknd 46 14 and and CC cord-010119-t1x9gknd 46 15 behavioral behavioral JJ cord-010119-t1x9gknd 46 16 risk risk NN cord-010119-t1x9gknd 46 17 factors factor NNS cord-010119-t1x9gknd 46 18 of of IN cord-010119-t1x9gknd 46 19 secondary secondary JJ cord-010119-t1x9gknd 46 20 importance importance NN cord-010119-t1x9gknd 46 21 . . . cord-010119-t1x9gknd 47 1 In in IN cord-010119-t1x9gknd 47 2 developing develop VBG cord-010119-t1x9gknd 47 3 iron iron NN cord-010119-t1x9gknd 47 4 mitigation mitigation NN cord-010119-t1x9gknd 47 5 strategies strategy NNS cord-010119-t1x9gknd 47 6 , , , cord-010119-t1x9gknd 47 7 practices practice NNS cord-010119-t1x9gknd 47 8 based base VBN cord-010119-t1x9gknd 47 9 on on IN cord-010119-t1x9gknd 47 10 age age NN cord-010119-t1x9gknd 47 11 and and CC cord-010119-t1x9gknd 47 12 gender gender NN cord-010119-t1x9gknd 47 13 could could MD cord-010119-t1x9gknd 47 14 be be VB cord-010119-t1x9gknd 47 15 further further RB cord-010119-t1x9gknd 47 16 refined refine VBN cord-010119-t1x9gknd 47 17 depending depending NN cord-010119-t1x9gknd 47 18 on on IN cord-010119-t1x9gknd 47 19 a a DT cord-010119-t1x9gknd 47 20 given give VBN cord-010119-t1x9gknd 47 21 blood blood NN cord-010119-t1x9gknd 47 22 center center NN cord-010119-t1x9gknd 47 23 's 's POS cord-010119-t1x9gknd 47 24 operational operational JJ cord-010119-t1x9gknd 47 25 context context NN cord-010119-t1x9gknd 47 26 and and CC cord-010119-t1x9gknd 47 27 donor donor NN cord-010119-t1x9gknd 47 28 population population NN cord-010119-t1x9gknd 47 29 . . . cord-010119-t1x9gknd 48 1 Data datum NNS cord-010119-t1x9gknd 48 2 are be VBP cord-010119-t1x9gknd 48 3 reported report VBN cord-010119-t1x9gknd 48 4 as as IN cord-010119-t1x9gknd 48 5 mean mean JJ cord-010119-t1x9gknd 48 6 ( ( -LRB- cord-010119-t1x9gknd 48 7 6SD 6sd NN cord-010119-t1x9gknd 48 8 ) ) -RRB- cord-010119-t1x9gknd 49 1 * * NFP cord-010119-t1x9gknd 49 2 P p XX cord-010119-t1x9gknd 49 3 < < XX cord-010119-t1x9gknd 49 4 0.05 0.05 CD cord-010119-t1x9gknd 49 5 compared compare VBN cord-010119-t1x9gknd 49 6 to to IN cord-010119-t1x9gknd 49 7 Batf31/1 batf31/1 VB cord-010119-t1x9gknd 49 8 , , , cord-010119-t1x9gknd 49 9 200uL 200ul CD cord-010119-t1x9gknd 49 10 HOD HOD NNP cord-010119-t1x9gknd 49 11 RBCs rbc NNS cord-010119-t1x9gknd 49 12 MFI MFI NNP cord-010119-t1x9gknd 49 13 , , , cord-010119-t1x9gknd 49 14 median median JJ cord-010119-t1x9gknd 49 15 fluorescence fluorescence NN cord-010119-t1x9gknd 49 16 intensity intensity NN cord-010119-t1x9gknd 49 17 Background Background NNP cord-010119-t1x9gknd 49 18 / / SYM cord-010119-t1x9gknd 49 19 Case Case NNP cord-010119-t1x9gknd 49 20 Studies Studies NNPS cord-010119-t1x9gknd 50 1 : : : cord-010119-t1x9gknd 50 2 During during IN cord-010119-t1x9gknd 50 3 storage storage NN cord-010119-t1x9gknd 50 4 , , , cord-010119-t1x9gknd 50 5 red red JJ cord-010119-t1x9gknd 50 6 blood blood NN cord-010119-t1x9gknd 50 7 cells cell NNS cord-010119-t1x9gknd 50 8 ( ( -LRB- cord-010119-t1x9gknd 50 9 RBCs rbc NNS cord-010119-t1x9gknd 50 10 ) ) -RRB- cord-010119-t1x9gknd 50 11 undergo undergo VB cord-010119-t1x9gknd 50 12 multiple multiple JJ cord-010119-t1x9gknd 50 13 morphological morphological JJ cord-010119-t1x9gknd 50 14 , , , cord-010119-t1x9gknd 50 15 biochemical biochemical JJ cord-010119-t1x9gknd 50 16 and and CC cord-010119-t1x9gknd 50 17 molecular molecular JJ cord-010119-t1x9gknd 50 18 modifications modification NNS cord-010119-t1x9gknd 50 19 , , , cord-010119-t1x9gknd 50 20 collectively collectively RB cord-010119-t1x9gknd 50 21 called call VBN cord-010119-t1x9gknd 50 22 the the DT cord-010119-t1x9gknd 50 23 storage storage NN cord-010119-t1x9gknd 50 24 lesion lesion NN cord-010119-t1x9gknd 50 25 . . . cord-010119-t1x9gknd 51 1 The the DT cord-010119-t1x9gknd 51 2 proportion proportion NN cord-010119-t1x9gknd 51 3 of of IN cord-010119-t1x9gknd 51 4 cleared clear VBN cord-010119-t1x9gknd 51 5 RBCs rbc NNS cord-010119-t1x9gknd 51 6 is be VBZ cord-010119-t1x9gknd 51 7 correlated correlate VBN cord-010119-t1x9gknd 51 8 with with IN cord-010119-t1x9gknd 51 9 storage storage NN cord-010119-t1x9gknd 51 10 duration duration NN cord-010119-t1x9gknd 51 11 , , , cord-010119-t1x9gknd 51 12 which which WDT cord-010119-t1x9gknd 51 13 may may MD cord-010119-t1x9gknd 51 14 be be VB cord-010119-t1x9gknd 51 15 responsible responsible JJ cord-010119-t1x9gknd 51 16 for for IN cord-010119-t1x9gknd 51 17 the the DT cord-010119-t1x9gknd 51 18 rapid rapid JJ cord-010119-t1x9gknd 51 19 clearance clearance NN cord-010119-t1x9gknd 51 20 of of IN cord-010119-t1x9gknd 51 21 up up IN cord-010119-t1x9gknd 51 22 to to TO cord-010119-t1x9gknd 51 23 25 25 CD cord-010119-t1x9gknd 51 24 % % NN cord-010119-t1x9gknd 51 25 of of IN cord-010119-t1x9gknd 51 26 transfused transfused JJ cord-010119-t1x9gknd 51 27 RBCs rbc NNS cord-010119-t1x9gknd 51 28 , , , cord-010119-t1x9gknd 51 29 reducing reduce VBG cord-010119-t1x9gknd 51 30 transfusion transfusion NN cord-010119-t1x9gknd 51 31 yield yield NN cord-010119-t1x9gknd 51 32 . . . cord-010119-t1x9gknd 52 1 It -PRON- PRP cord-010119-t1x9gknd 52 2 has have VBZ cord-010119-t1x9gknd 52 3 been be VBN cord-010119-t1x9gknd 52 4 shown show VBN cord-010119-t1x9gknd 52 5 , , , cord-010119-t1x9gknd 52 6 using use VBG cord-010119-t1x9gknd 52 7 imaging image VBG cord-010119-t1x9gknd 52 8 flow flow NN cord-010119-t1x9gknd 52 9 cytometry cytometry NN cord-010119-t1x9gknd 52 10 that that IN cord-010119-t1x9gknd 52 11 a a DT cord-010119-t1x9gknd 52 12 subpopulation subpopulation NN cord-010119-t1x9gknd 52 13 of of IN cord-010119-t1x9gknd 52 14 morphologically morphologically RB cord-010119-t1x9gknd 52 15 altered alter VBN cord-010119-t1x9gknd 52 16 RBCs rbc NNS cord-010119-t1x9gknd 52 17 accumulates accumulate VBZ cord-010119-t1x9gknd 52 18 during during IN cord-010119-t1x9gknd 52 19 storage storage NN cord-010119-t1x9gknd 52 20 . . . cord-010119-t1x9gknd 53 1 The the DT cord-010119-t1x9gknd 53 2 reduced reduce VBN cord-010119-t1x9gknd 53 3 surface surface NN cord-010119-t1x9gknd 53 4 area area NN cord-010119-t1x9gknd 53 5 of of IN cord-010119-t1x9gknd 53 6 these these DT cord-010119-t1x9gknd 53 7 small small JJ cord-010119-t1x9gknd 53 8 RBCs rbc NNS cord-010119-t1x9gknd 53 9 ( ( -LRB- cord-010119-t1x9gknd 53 10 sRBCs srbcs RB cord-010119-t1x9gknd 53 11 ) ) -RRB- cord-010119-t1x9gknd 53 12 suggests suggest VBZ cord-010119-t1x9gknd 53 13 their -PRON- PRP$ cord-010119-t1x9gknd 53 14 rapid rapid JJ cord-010119-t1x9gknd 53 15 elimination elimination NN cord-010119-t1x9gknd 53 16 by by IN cord-010119-t1x9gknd 53 17 the the DT cord-010119-t1x9gknd 53 18 spleen spleen NNS cord-010119-t1x9gknd 53 19 in in IN cord-010119-t1x9gknd 53 20 the the DT cord-010119-t1x9gknd 53 21 hours hour NNS cord-010119-t1x9gknd 53 22 following follow VBG cord-010119-t1x9gknd 53 23 transfusion transfusion NN cord-010119-t1x9gknd 53 24 . . . cord-010119-t1x9gknd 54 1 This this DT cord-010119-t1x9gknd 54 2 hypothesis hypothesis NN cord-010119-t1x9gknd 54 3 remains remain VBZ cord-010119-t1x9gknd 54 4 to to TO cord-010119-t1x9gknd 54 5 be be VB cord-010119-t1x9gknd 54 6 clarified clarify VBN cord-010119-t1x9gknd 54 7 , , , cord-010119-t1x9gknd 54 8 since since IN cord-010119-t1x9gknd 54 9 the the DT cord-010119-t1x9gknd 54 10 physiological physiological JJ cord-010119-t1x9gknd 54 11 mechanisms mechanism NNS cord-010119-t1x9gknd 54 12 of of IN cord-010119-t1x9gknd 54 13 RBC RBC NNP cord-010119-t1x9gknd 54 14 clearance clearance NN cord-010119-t1x9gknd 54 15 remain remain VBP cord-010119-t1x9gknd 54 16 to to TO cord-010119-t1x9gknd 54 17 be be VB cord-010119-t1x9gknd 54 18 precisely precisely RB cord-010119-t1x9gknd 54 19 identified identify VBN cord-010119-t1x9gknd 54 20 . . . cord-010119-t1x9gknd 55 1 Study Study NNP cord-010119-t1x9gknd 55 2 Design Design NNP cord-010119-t1x9gknd 55 3 / / SYM cord-010119-t1x9gknd 55 4 Method method NN cord-010119-t1x9gknd 55 5 : : : cord-010119-t1x9gknd 55 6 Murine murine JJ cord-010119-t1x9gknd 55 7 " " `` cord-010119-t1x9gknd 55 8 young young JJ cord-010119-t1x9gknd 55 9 " " '' cord-010119-t1x9gknd 55 10 and and CC cord-010119-t1x9gknd 55 11 " " `` cord-010119-t1x9gknd 55 12 old old JJ cord-010119-t1x9gknd 55 13 " " '' cord-010119-t1x9gknd 55 14 RBCs rbc NNS cord-010119-t1x9gknd 55 15 ( ( -LRB- cord-010119-t1x9gknd 55 16 respectively respectively RB cord-010119-t1x9gknd 55 17 on on IN cord-010119-t1x9gknd 55 18 D1 D1 NNP cord-010119-t1x9gknd 55 19 and and CC cord-010119-t1x9gknd 55 20 D14 D14 NNP cord-010119-t1x9gknd 55 21 of of IN cord-010119-t1x9gknd 55 22 storage storage NN cord-010119-t1x9gknd 55 23 ) ) -RRB- cord-010119-t1x9gknd 55 24 were be VBD cord-010119-t1x9gknd 55 25 transfused transfuse VBN cord-010119-t1x9gknd 55 26 into into IN cord-010119-t1x9gknd 55 27 different different JJ cord-010119-t1x9gknd 55 28 models model NNS cord-010119-t1x9gknd 55 29 including include VBG cord-010119-t1x9gknd 55 30 splenectomized splenectomize VBN cord-010119-t1x9gknd 55 31 or or CC cord-010119-t1x9gknd 55 32 macrophage macrophage NN cord-010119-t1x9gknd 55 33 - - HYPH cord-010119-t1x9gknd 55 34 depleted deplete VBN cord-010119-t1x9gknd 55 35 mice mouse NNS cord-010119-t1x9gknd 55 36 . . . cord-010119-t1x9gknd 56 1 Flow flow NN cord-010119-t1x9gknd 56 2 cytometry cytometry NN cord-010119-t1x9gknd 56 3 was be VBD cord-010119-t1x9gknd 56 4 used use VBN cord-010119-t1x9gknd 56 5 to to TO cord-010119-t1x9gknd 56 6 determine determine VB cord-010119-t1x9gknd 56 7 the the DT cord-010119-t1x9gknd 56 8 kinetics kinetic NNS cord-010119-t1x9gknd 56 9 of of IN cord-010119-t1x9gknd 56 10 clearance clearance NN cord-010119-t1x9gknd 56 11 , , , cord-010119-t1x9gknd 56 12 the the DT cord-010119-t1x9gknd 56 13 transfusion transfusion NN cord-010119-t1x9gknd 56 14 yield yield NN cord-010119-t1x9gknd 56 15 and and CC cord-010119-t1x9gknd 56 16 to to TO cord-010119-t1x9gknd 56 17 quantify quantify VB cord-010119-t1x9gknd 56 18 RBCs rbc NNS cord-010119-t1x9gknd 56 19 retention retention NN cord-010119-t1x9gknd 56 20 in in IN cord-010119-t1x9gknd 56 21 organs organ NNS cord-010119-t1x9gknd 56 22 . . . cord-010119-t1x9gknd 57 1 The the DT cord-010119-t1x9gknd 57 2 accumulation accumulation NN cord-010119-t1x9gknd 57 3 , , , cord-010119-t1x9gknd 57 4 during during IN cord-010119-t1x9gknd 57 5 storage storage NN cord-010119-t1x9gknd 57 6 , , , cord-010119-t1x9gknd 57 7 and and CC cord-010119-t1x9gknd 57 8 the the DT cord-010119-t1x9gknd 57 9 posttransfusion posttransfusion NN cord-010119-t1x9gknd 57 10 disappearance disappearance NN cord-010119-t1x9gknd 57 11 of of IN cord-010119-t1x9gknd 57 12 sRBCs srbcs PRP cord-010119-t1x9gknd 57 13 were be VBD cord-010119-t1x9gknd 57 14 analyzed analyze VBN cord-010119-t1x9gknd 57 15 by by IN cord-010119-t1x9gknd 57 16 imaging image VBG cord-010119-t1x9gknd 57 17 flow flow NN cord-010119-t1x9gknd 57 18 cytometry cytometry NN cord-010119-t1x9gknd 57 19 . . . cord-010119-t1x9gknd 58 1 Results result NNS cord-010119-t1x9gknd 58 2 / / SYM cord-010119-t1x9gknd 58 3 Finding finding NN cord-010119-t1x9gknd 58 4 : : : cord-010119-t1x9gknd 58 5 Using use VBG cord-010119-t1x9gknd 58 6 a a DT cord-010119-t1x9gknd 58 7 murine murine JJ cord-010119-t1x9gknd 58 8 model model NN cord-010119-t1x9gknd 58 9 of of IN cord-010119-t1x9gknd 58 10 transfusion transfusion NN cord-010119-t1x9gknd 58 11 , , , cord-010119-t1x9gknd 58 12 we -PRON- PRP cord-010119-t1x9gknd 58 13 confirmed confirm VBD cord-010119-t1x9gknd 58 14 that that IN cord-010119-t1x9gknd 58 15 the the DT cord-010119-t1x9gknd 58 16 post post JJ cord-010119-t1x9gknd 58 17 - - JJ cord-010119-t1x9gknd 58 18 transfusion transfusion JJ cord-010119-t1x9gknd 58 19 yield yield NN cord-010119-t1x9gknd 58 20 decreases decrease VBZ cord-010119-t1x9gknd 58 21 with with IN cord-010119-t1x9gknd 58 22 storage storage NN cord-010119-t1x9gknd 58 23 duration duration NN cord-010119-t1x9gknd 58 24 ( ( -LRB- cord-010119-t1x9gknd 58 25 62 62 CD cord-010119-t1x9gknd 58 26 % % NN cord-010119-t1x9gknd 58 27 on on IN cord-010119-t1x9gknd 58 28 D14 D14 NNP cord-010119-t1x9gknd 58 29 vs vs IN cord-010119-t1x9gknd 58 30 100 100 CD cord-010119-t1x9gknd 58 31 % % NN cord-010119-t1x9gknd 58 32 on on IN cord-010119-t1x9gknd 58 33 D1 d1 NN cord-010119-t1x9gknd 58 34 of of IN cord-010119-t1x9gknd 58 35 storage storage NN cord-010119-t1x9gknd 58 36 ) ) -RRB- cord-010119-t1x9gknd 58 37 . . . cord-010119-t1x9gknd 59 1 A a DT cord-010119-t1x9gknd 59 2 clearance clearance NN cord-010119-t1x9gknd 59 3 of of IN cord-010119-t1x9gknd 59 4 the the DT cord-010119-t1x9gknd 59 5 storage storage NN cord-010119-t1x9gknd 59 6 - - HYPH cord-010119-t1x9gknd 59 7 damaged damage VBN cord-010119-t1x9gknd 59 8 RBCs rbc NNS cord-010119-t1x9gknd 59 9 mediated mediate VBN cord-010119-t1x9gknd 59 10 by by IN cord-010119-t1x9gknd 59 11 spleen spleen NNS cord-010119-t1x9gknd 59 12 and and CC cord-010119-t1x9gknd 59 13 macrophages macrophage NNS cord-010119-t1x9gknd 59 14 is be VBZ cord-010119-t1x9gknd 59 15 shown show VBN cord-010119-t1x9gknd 59 16 by by IN cord-010119-t1x9gknd 59 17 significant significant JJ cord-010119-t1x9gknd 59 18 improvements improvement NNS cord-010119-t1x9gknd 59 19 in in IN cord-010119-t1x9gknd 59 20 post post JJ cord-010119-t1x9gknd 59 21 - - JJ cord-010119-t1x9gknd 59 22 transfusion transfusion JJ cord-010119-t1x9gknd 59 23 yield yield NN cord-010119-t1x9gknd 59 24 observed observe VBN cord-010119-t1x9gknd 59 25 in in IN cord-010119-t1x9gknd 59 26 the the DT cord-010119-t1x9gknd 59 27 splenectomized splenectomized JJ cord-010119-t1x9gknd 59 28 ( ( -LRB- cord-010119-t1x9gknd 59 29 74 74 CD cord-010119-t1x9gknd 59 30 % % NN cord-010119-t1x9gknd 59 31 ) ) -RRB- cord-010119-t1x9gknd 59 32 and and CC cord-010119-t1x9gknd 59 33 macrophage macrophage NN cord-010119-t1x9gknd 59 34 - - HYPH cord-010119-t1x9gknd 59 35 depleted deplete VBN cord-010119-t1x9gknd 59 36 ( ( -LRB- cord-010119-t1x9gknd 59 37 79 79 CD cord-010119-t1x9gknd 59 38 % % NN cord-010119-t1x9gknd 59 39 ) ) -RRB- cord-010119-t1x9gknd 59 40 groups group NNS cord-010119-t1x9gknd 59 41 . . . cord-010119-t1x9gknd 60 1 As as IN cord-010119-t1x9gknd 60 2 in in IN cord-010119-t1x9gknd 60 3 humans human NNS cord-010119-t1x9gknd 60 4 , , , cord-010119-t1x9gknd 60 5 we -PRON- PRP cord-010119-t1x9gknd 60 6 observed observe VBD cord-010119-t1x9gknd 60 7 the the DT cord-010119-t1x9gknd 60 8 accumulation accumulation NN cord-010119-t1x9gknd 60 9 of of IN cord-010119-t1x9gknd 60 10 a a DT cord-010119-t1x9gknd 60 11 subpopulation subpopulation NN cord-010119-t1x9gknd 60 12 of of IN cord-010119-t1x9gknd 60 13 small small JJ cord-010119-t1x9gknd 60 14 RBCs rbc NNS cord-010119-t1x9gknd 60 15 ( ( -LRB- cord-010119-t1x9gknd 60 16 mouse mouse VB cord-010119-t1x9gknd 60 17 small small JJ cord-010119-t1x9gknd 60 18 RBC RBC NNP cord-010119-t1x9gknd 60 19 : : : cord-010119-t1x9gknd 60 20 msRBC msRBC NNP cord-010119-t1x9gknd 60 21 ) ) -RRB- cord-010119-t1x9gknd 60 22 of of IN cord-010119-t1x9gknd 60 23 reduced reduce VBN cord-010119-t1x9gknd 60 24 projected project VBN cord-010119-t1x9gknd 60 25 surface surface NN cord-010119-t1x9gknd 60 26 area area NN cord-010119-t1x9gknd 60 27 with with IN cord-010119-t1x9gknd 60 28 altered altered JJ cord-010119-t1x9gknd 60 29 morphology morphology NN cord-010119-t1x9gknd 60 30 . . . cord-010119-t1x9gknd 61 1 These these DT cord-010119-t1x9gknd 61 2 msRBCs msRBCs NNP cord-010119-t1x9gknd 61 3 disappear disappear VBP cord-010119-t1x9gknd 61 4 rapidly rapidly RB cord-010119-t1x9gknd 61 5 from from IN cord-010119-t1x9gknd 61 6 the the DT cord-010119-t1x9gknd 61 7 circulation circulation NN cord-010119-t1x9gknd 61 8 in in IN cord-010119-t1x9gknd 61 9 control control NN cord-010119-t1x9gknd 61 10 or or CC cord-010119-t1x9gknd 61 11 splenectomized splenectomize VBD cord-010119-t1x9gknd 61 12 mice mouse NNS cord-010119-t1x9gknd 61 13 with with IN cord-010119-t1x9gknd 61 14 a a DT cord-010119-t1x9gknd 61 15 decrease decrease NN cord-010119-t1x9gknd 61 16 of of IN cord-010119-t1x9gknd 61 17 more more JJR cord-010119-t1x9gknd 61 18 than than IN cord-010119-t1x9gknd 61 19 50 50 CD cord-010119-t1x9gknd 61 20 % % NN cord-010119-t1x9gknd 61 21 at at IN cord-010119-t1x9gknd 61 22 2h 2h CD cord-010119-t1x9gknd 61 23 post post NN cord-010119-t1x9gknd 61 24 - - NN cord-010119-t1x9gknd 61 25 transfusion transfusion NN cord-010119-t1x9gknd 61 26 . . . cord-010119-t1x9gknd 62 1 In in IN cord-010119-t1x9gknd 62 2 contrast contrast NN cord-010119-t1x9gknd 62 3 , , , cord-010119-t1x9gknd 62 4 in in IN cord-010119-t1x9gknd 62 5 macrophage macrophage NN cord-010119-t1x9gknd 62 6 - - HYPH cord-010119-t1x9gknd 62 7 depleted deplete VBN cord-010119-t1x9gknd 62 8 mice mouse NNS cord-010119-t1x9gknd 62 9 , , , cord-010119-t1x9gknd 62 10 msRBCs msRBCs NNP cord-010119-t1x9gknd 62 11 are be VBP cord-010119-t1x9gknd 62 12 kept keep VBN cord-010119-t1x9gknd 62 13 in in IN cord-010119-t1x9gknd 62 14 circulation circulation NN cord-010119-t1x9gknd 62 15 at at IN cord-010119-t1x9gknd 62 16 2h 2h CD cord-010119-t1x9gknd 62 17 posttransfusion posttransfusion NNP cord-010119-t1x9gknd 62 18 . . . cord-010119-t1x9gknd 63 1 At at IN cord-010119-t1x9gknd 63 2 24h 24h NNS cord-010119-t1x9gknd 63 3 , , , cord-010119-t1x9gknd 63 4 these these DT cord-010119-t1x9gknd 63 5 msRBCs msRBCs NNP cord-010119-t1x9gknd 63 6 completely completely RB cord-010119-t1x9gknd 63 7 disappear disappear VBP cord-010119-t1x9gknd 63 8 in in IN cord-010119-t1x9gknd 63 9 all all DT cord-010119-t1x9gknd 63 10 models model NNS cord-010119-t1x9gknd 63 11 , , , cord-010119-t1x9gknd 63 12 suggesting suggest VBG cord-010119-t1x9gknd 63 13 the the DT cord-010119-t1x9gknd 63 14 importance importance NN cord-010119-t1x9gknd 63 15 of of IN cord-010119-t1x9gknd 63 16 their -PRON- PRP$ cord-010119-t1x9gknd 63 17 elimination elimination NN cord-010119-t1x9gknd 63 18 and and CC cord-010119-t1x9gknd 63 19 the the DT cord-010119-t1x9gknd 63 20 presence presence NN cord-010119-t1x9gknd 63 21 of of IN cord-010119-t1x9gknd 63 22 compensation compensation NN cord-010119-t1x9gknd 63 23 clearance clearance NN cord-010119-t1x9gknd 63 24 mechanisms mechanism NNS cord-010119-t1x9gknd 63 25 . . . cord-010119-t1x9gknd 64 1 In in IN cord-010119-t1x9gknd 64 2 control control NN cord-010119-t1x9gknd 64 3 mice mouse NNS cord-010119-t1x9gknd 64 4 , , , cord-010119-t1x9gknd 64 5 storage storage NN cord-010119-t1x9gknd 64 6 - - HYPH cord-010119-t1x9gknd 64 7 damaged damage VBN cord-010119-t1x9gknd 64 8 RBCs rbc NNS cord-010119-t1x9gknd 64 9 are be VBP cord-010119-t1x9gknd 64 10 mostly mostly RB cord-010119-t1x9gknd 64 11 retained retain VBN cord-010119-t1x9gknd 64 12 in in IN cord-010119-t1x9gknd 64 13 the the DT cord-010119-t1x9gknd 64 14 spleen spleen NN cord-010119-t1x9gknd 64 15 but but CC cord-010119-t1x9gknd 64 16 also also RB cord-010119-t1x9gknd 64 17 in in IN cord-010119-t1x9gknd 64 18 the the DT cord-010119-t1x9gknd 64 19 bone bone NN cord-010119-t1x9gknd 64 20 marrow marrow NN cord-010119-t1x9gknd 64 21 ( ( -LRB- cord-010119-t1x9gknd 64 22 BM BM NNP cord-010119-t1x9gknd 64 23 ) ) -RRB- cord-010119-t1x9gknd 64 24 . . . cord-010119-t1x9gknd 65 1 No no DT cord-010119-t1x9gknd 65 2 retention retention NN cord-010119-t1x9gknd 65 3 is be VBZ cord-010119-t1x9gknd 65 4 observed observe VBN cord-010119-t1x9gknd 65 5 in in IN cord-010119-t1x9gknd 65 6 the the DT cord-010119-t1x9gknd 65 7 liver liver NN cord-010119-t1x9gknd 65 8 , , , cord-010119-t1x9gknd 65 9 kidney kidney NN cord-010119-t1x9gknd 65 10 or or CC cord-010119-t1x9gknd 65 11 lung lung NN cord-010119-t1x9gknd 65 12 . . . cord-010119-t1x9gknd 66 1 In in IN cord-010119-t1x9gknd 66 2 macrophage macrophage NN cord-010119-t1x9gknd 66 3 - - HYPH cord-010119-t1x9gknd 66 4 depleted deplete VBN cord-010119-t1x9gknd 66 5 mice mice NN cord-010119-t1x9gknd 66 6 , , , cord-010119-t1x9gknd 66 7 retention retention NN cord-010119-t1x9gknd 66 8 is be VBZ cord-010119-t1x9gknd 66 9 decreased decrease VBN cord-010119-t1x9gknd 66 10 in in IN cord-010119-t1x9gknd 66 11 the the DT cord-010119-t1x9gknd 66 12 spleen spleen NNS cord-010119-t1x9gknd 66 13 and and CC cord-010119-t1x9gknd 66 14 BM bm NN cord-010119-t1x9gknd 66 15 . . . cord-010119-t1x9gknd 67 1 Conversely conversely RB cord-010119-t1x9gknd 67 2 , , , cord-010119-t1x9gknd 67 3 elevated elevated JJ cord-010119-t1x9gknd 67 4 retention retention NN cord-010119-t1x9gknd 67 5 is be VBZ cord-010119-t1x9gknd 67 6 observed observe VBN cord-010119-t1x9gknd 67 7 in in IN cord-010119-t1x9gknd 67 8 the the DT cord-010119-t1x9gknd 67 9 BM BM NNP cord-010119-t1x9gknd 67 10 of of IN cord-010119-t1x9gknd 67 11 splenectomized splenectomized JJ cord-010119-t1x9gknd 67 12 mice mouse NNS cord-010119-t1x9gknd 67 13 , , , cord-010119-t1x9gknd 67 14 associated associate VBN cord-010119-t1x9gknd 67 15 with with IN cord-010119-t1x9gknd 67 16 a a DT cord-010119-t1x9gknd 67 17 transient transient JJ cord-010119-t1x9gknd 67 18 retention retention NN cord-010119-t1x9gknd 67 19 in in IN cord-010119-t1x9gknd 67 20 the the DT cord-010119-t1x9gknd 67 21 kidney kidney NN cord-010119-t1x9gknd 67 22 and and CC cord-010119-t1x9gknd 67 23 liver liver NN cord-010119-t1x9gknd 67 24 . . . cord-010119-t1x9gknd 68 1 Conclusion conclusion NN cord-010119-t1x9gknd 68 2 : : : cord-010119-t1x9gknd 69 1 During during IN cord-010119-t1x9gknd 69 2 storage storage NN cord-010119-t1x9gknd 69 3 of of IN cord-010119-t1x9gknd 69 4 murine murine JJ cord-010119-t1x9gknd 69 5 RBCs rbc NNS cord-010119-t1x9gknd 69 6 , , , cord-010119-t1x9gknd 69 7 damaged damaged JJ cord-010119-t1x9gknd 69 8 RBCs rbc NNS cord-010119-t1x9gknd 69 9 accumulate accumulate VBP cord-010119-t1x9gknd 69 10 , , , cord-010119-t1x9gknd 69 11 and and CC cord-010119-t1x9gknd 69 12 are be VBP cord-010119-t1x9gknd 69 13 eliminated eliminate VBN cord-010119-t1x9gknd 69 14 following follow VBG cord-010119-t1x9gknd 69 15 transfusion transfusion NN cord-010119-t1x9gknd 69 16 via via IN cord-010119-t1x9gknd 69 17 spleen spleen NN cord-010119-t1x9gknd 69 18 / / SYM cord-010119-t1x9gknd 69 19 macrophage macrophage NN cord-010119-t1x9gknd 69 20 - - HYPH cord-010119-t1x9gknd 69 21 mediated mediate VBN cord-010119-t1x9gknd 69 22 mechanisms mechanism NNS cord-010119-t1x9gknd 69 23 . . . cord-010119-t1x9gknd 70 1 They -PRON- PRP cord-010119-t1x9gknd 70 2 include include VBP cord-010119-t1x9gknd 70 3 , , , cord-010119-t1x9gknd 70 4 as as IN cord-010119-t1x9gknd 70 5 observed observe VBN cord-010119-t1x9gknd 70 6 in in IN cord-010119-t1x9gknd 70 7 humans human NNS cord-010119-t1x9gknd 70 8 , , , cord-010119-t1x9gknd 70 9 a a DT cord-010119-t1x9gknd 70 10 subpopulation subpopulation NN cord-010119-t1x9gknd 70 11 of of IN cord-010119-t1x9gknd 70 12 small small JJ cord-010119-t1x9gknd 70 13 RBCs rbc NNS cord-010119-t1x9gknd 70 14 which which WDT cord-010119-t1x9gknd 70 15 undergoes undergo VBZ cord-010119-t1x9gknd 70 16 a a DT cord-010119-t1x9gknd 70 17 rapid rapid JJ cord-010119-t1x9gknd 70 18 macrophage macrophage NN cord-010119-t1x9gknd 70 19 - - HYPH cord-010119-t1x9gknd 70 20 mediated mediate VBN cord-010119-t1x9gknd 70 21 clearance clearance NN cord-010119-t1x9gknd 70 22 . . . cord-010119-t1x9gknd 71 1 The the DT cord-010119-t1x9gknd 71 2 increase increase NN cord-010119-t1x9gknd 71 3 in in IN cord-010119-t1x9gknd 71 4 transfusion transfusion NN cord-010119-t1x9gknd 71 5 yield yield NN cord-010119-t1x9gknd 71 6 in in IN cord-010119-t1x9gknd 71 7 the the DT cord-010119-t1x9gknd 71 8 absence absence NN cord-010119-t1x9gknd 71 9 of of IN cord-010119-t1x9gknd 71 10 spleen spleen NNS cord-010119-t1x9gknd 71 11 or or CC cord-010119-t1x9gknd 71 12 macrophages macrophage NNS cord-010119-t1x9gknd 71 13 suggests suggest VBZ cord-010119-t1x9gknd 71 14 that that IN cord-010119-t1x9gknd 71 15 the the DT cord-010119-t1x9gknd 71 16 recipient recipient NN cord-010119-t1x9gknd 71 17 's 's POS cord-010119-t1x9gknd 71 18 functional functional JJ cord-010119-t1x9gknd 71 19 state state NN cord-010119-t1x9gknd 71 20 is be VBZ cord-010119-t1x9gknd 71 21 one one CD cord-010119-t1x9gknd 71 22 of of IN cord-010119-t1x9gknd 71 23 its -PRON- PRP$ cord-010119-t1x9gknd 71 24 determining determine VBG cord-010119-t1x9gknd 71 25 factors factor NNS cord-010119-t1x9gknd 71 26 . . . cord-010119-t1x9gknd 72 1 Age age NN cord-010119-t1x9gknd 72 2 Dependent dependent JJ cord-010119-t1x9gknd 72 3 Relapsing relapse VBG cord-010119-t1x9gknd 72 4 and and CC cord-010119-t1x9gknd 72 5 Remitting remit VBG cord-010119-t1x9gknd 72 6 Autoimmune autoimmune JJ cord-010119-t1x9gknd 72 7 Hemolytic hemolytic JJ cord-010119-t1x9gknd 72 8 Anemia anemia NN cord-010119-t1x9gknd 72 9 in in IN cord-010119-t1x9gknd 72 10 a a DT cord-010119-t1x9gknd 72 11 Murine Murine NNP cord-010119-t1x9gknd 72 12 Model Model NNP cord-010119-t1x9gknd 72 13 Andrea Andrea NNP cord-010119-t1x9gknd 72 14 Sut Sut NNP cord-010119-t1x9gknd 72 15 Ling Ling NNP cord-010119-t1x9gknd 72 16 Wong Wong NNP cord-010119-t1x9gknd 73 1 * * NFP cord-010119-t1x9gknd 73 2 1 1 CD cord-010119-t1x9gknd 73 3 , , , cord-010119-t1x9gknd 73 4 Amanda Amanda NNP cord-010119-t1x9gknd 73 5 L L NNP cord-010119-t1x9gknd 73 6 Richards Richards NNP cord-010119-t1x9gknd 73 7 2 2 CD cord-010119-t1x9gknd 73 8 and and CC cord-010119-t1x9gknd 73 9 Krystalyn Krystalyn NNP cord-010119-t1x9gknd 73 10 E E NNP cord-010119-t1x9gknd 73 11 Hudson Hudson NNP cord-010119-t1x9gknd 73 12 2 2 CD cord-010119-t1x9gknd 73 13 . . . cord-010119-t1x9gknd 74 1 Background Background NNP cord-010119-t1x9gknd 74 2 / / SYM cord-010119-t1x9gknd 74 3 Case Case NNP cord-010119-t1x9gknd 74 4 Studies Studies NNPS cord-010119-t1x9gknd 74 5 : : : cord-010119-t1x9gknd 75 1 Breakdown breakdown NN cord-010119-t1x9gknd 75 2 of of IN cord-010119-t1x9gknd 75 3 tolerance tolerance NN cord-010119-t1x9gknd 75 4 to to IN cord-010119-t1x9gknd 75 5 RBC RBC NNP cord-010119-t1x9gknd 75 6 antigens antigen NNS cord-010119-t1x9gknd 75 7 may may MD cord-010119-t1x9gknd 75 8 result result VB cord-010119-t1x9gknd 75 9 in in IN cord-010119-t1x9gknd 75 10 development development NN cord-010119-t1x9gknd 75 11 of of IN cord-010119-t1x9gknd 75 12 pathogenic pathogenic JJ cord-010119-t1x9gknd 75 13 autoantibodies autoantibody NNS cord-010119-t1x9gknd 75 14 ( ( -LRB- cord-010119-t1x9gknd 75 15 autoAb autoAb NNP cord-010119-t1x9gknd 75 16 ) ) -RRB- cord-010119-t1x9gknd 75 17 and and CC cord-010119-t1x9gknd 75 18 lead lead VB cord-010119-t1x9gknd 75 19 to to IN cord-010119-t1x9gknd 75 20 autoimmune autoimmune JJ cord-010119-t1x9gknd 75 21 hemolytic hemolytic JJ cord-010119-t1x9gknd 75 22 anemia anemia NN cord-010119-t1x9gknd 75 23 ( ( -LRB- cord-010119-t1x9gknd 75 24 AIHA AIHA NNP cord-010119-t1x9gknd 75 25 ) ) -RRB- cord-010119-t1x9gknd 75 26 , , , cord-010119-t1x9gknd 75 27 a a DT cord-010119-t1x9gknd 75 28 severe severe JJ cord-010119-t1x9gknd 75 29 and and CC cord-010119-t1x9gknd 75 30 sometimes sometimes RB cord-010119-t1x9gknd 75 31 fatal fatal JJ cord-010119-t1x9gknd 75 32 disease disease NN cord-010119-t1x9gknd 75 33 . . . cord-010119-t1x9gknd 76 1 AIHA AIHA NNP cord-010119-t1x9gknd 76 2 in in IN cord-010119-t1x9gknd 76 3 humans human NNS cord-010119-t1x9gknd 76 4 has have VBZ cord-010119-t1x9gknd 76 5 a a DT cord-010119-t1x9gknd 76 6 number number NN cord-010119-t1x9gknd 76 7 of of IN cord-010119-t1x9gknd 76 8 known know VBN cord-010119-t1x9gknd 76 9 features feature NNS cord-010119-t1x9gknd 76 10 , , , cord-010119-t1x9gknd 76 11 including include VBG cord-010119-t1x9gknd 76 12 increased increase VBN cord-010119-t1x9gknd 76 13 frequency frequency NN cord-010119-t1x9gknd 76 14 with with IN cord-010119-t1x9gknd 76 15 age age NN cord-010119-t1x9gknd 76 16 , , , cord-010119-t1x9gknd 76 17 and and CC cord-010119-t1x9gknd 76 18 tendency tendency VBP cord-010119-t1x9gknd 76 19 to to TO cord-010119-t1x9gknd 76 20 relapse relapse VB cord-010119-t1x9gknd 76 21 and and CC cord-010119-t1x9gknd 76 22 remit remit VB cord-010119-t1x9gknd 76 23 . . . cord-010119-t1x9gknd 77 1 However however RB cord-010119-t1x9gknd 77 2 , , , cord-010119-t1x9gknd 77 3 the the DT cord-010119-t1x9gknd 77 4 mechanisms mechanism NNS cord-010119-t1x9gknd 77 5 behind behind IN cord-010119-t1x9gknd 77 6 such such JJ cord-010119-t1x9gknd 77 7 observations observation NNS cord-010119-t1x9gknd 77 8 are be VBP cord-010119-t1x9gknd 77 9 not not RB cord-010119-t1x9gknd 77 10 understood understand VBN cord-010119-t1x9gknd 77 11 . . . cord-010119-t1x9gknd 78 1 To to TO cord-010119-t1x9gknd 78 2 gain gain VB cord-010119-t1x9gknd 78 3 insight insight NN cord-010119-t1x9gknd 78 4 into into IN cord-010119-t1x9gknd 78 5 tolerance tolerance NN cord-010119-t1x9gknd 78 6 ( ( -LRB- cord-010119-t1x9gknd 78 7 or or CC cord-010119-t1x9gknd 78 8 loss loss NN cord-010119-t1x9gknd 78 9 thereof thereof RB cord-010119-t1x9gknd 78 10 ) ) -RRB- cord-010119-t1x9gknd 78 11 to to IN cord-010119-t1x9gknd 78 12 an an DT cord-010119-t1x9gknd 78 13 RBC RBC NNP cord-010119-t1x9gknd 78 14 autoantigen autoantigen NN cord-010119-t1x9gknd 78 15 , , , cord-010119-t1x9gknd 78 16 we -PRON- PRP cord-010119-t1x9gknd 78 17 utilized utilize VBD cord-010119-t1x9gknd 78 18 the the DT cord-010119-t1x9gknd 78 19 HOD HOD NNP cord-010119-t1x9gknd 78 20 mouse mouse NN cord-010119-t1x9gknd 78 21 , , , cord-010119-t1x9gknd 78 22 which which WDT cord-010119-t1x9gknd 78 23 expresses express VBZ cord-010119-t1x9gknd 78 24 an an DT cord-010119-t1x9gknd 78 25 RBC RBC NNP cord-010119-t1x9gknd 78 26 - - HYPH cord-010119-t1x9gknd 78 27 specific specific JJ cord-010119-t1x9gknd 78 28 triple triple JJ cord-010119-t1x9gknd 78 29 fusion fusion NN cord-010119-t1x9gknd 78 30 protein protein NN cord-010119-t1x9gknd 78 31 consisting consist VBG cord-010119-t1x9gknd 78 32 of of IN cord-010119-t1x9gknd 78 33 hen hen NN cord-010119-t1x9gknd 78 34 egg egg NN cord-010119-t1x9gknd 78 35 lysosyme lysosyme NNPS cord-010119-t1x9gknd 78 36 ( ( -LRB- cord-010119-t1x9gknd 78 37 HEL HEL NNP cord-010119-t1x9gknd 78 38 ) ) -RRB- cord-010119-t1x9gknd 78 39 , , , cord-010119-t1x9gknd 78 40 ovalbumin ovalbumin FW cord-010119-t1x9gknd 78 41 ( ( -LRB- cord-010119-t1x9gknd 78 42 OVA OVA NNP cord-010119-t1x9gknd 78 43 ) ) -RRB- cord-010119-t1x9gknd 78 44 , , , cord-010119-t1x9gknd 78 45 and and CC cord-010119-t1x9gknd 78 46 , , , cord-010119-t1x9gknd 78 47 Duffy Duffy NNP cord-010119-t1x9gknd 78 48 ( ( -LRB- cord-010119-t1x9gknd 78 49 HOD HOD NNP cord-010119-t1x9gknd 78 50 ) ) -RRB- cord-010119-t1x9gknd 78 51 . . . cord-010119-t1x9gknd 79 1 HOD HOD NNP cord-010119-t1x9gknd 79 2 mice mouse NNS cord-010119-t1x9gknd 79 3 were be VBD cord-010119-t1x9gknd 79 4 bred breed VBN cord-010119-t1x9gknd 79 5 to to IN cord-010119-t1x9gknd 79 6 a a DT cord-010119-t1x9gknd 79 7 transgenic transgenic JJ cord-010119-t1x9gknd 79 8 mouse mouse NN cord-010119-t1x9gknd 79 9 that that WDT cord-010119-t1x9gknd 79 10 expresses express VBZ cord-010119-t1x9gknd 79 11 a a DT cord-010119-t1x9gknd 79 12 T T NNP cord-010119-t1x9gknd 79 13 cell cell NN cord-010119-t1x9gknd 79 14 receptor receptor NN cord-010119-t1x9gknd 79 15 specific specific JJ cord-010119-t1x9gknd 79 16 for for IN cord-010119-t1x9gknd 79 17 an an DT cord-010119-t1x9gknd 79 18 OVA OVA NNP cord-010119-t1x9gknd 79 19 peptide peptide NN cord-010119-t1x9gknd 79 20 in in IN cord-010119-t1x9gknd 79 21 HOD HOD NNP cord-010119-t1x9gknd 79 22 presented present VBN cord-010119-t1x9gknd 79 23 by by IN cord-010119-t1x9gknd 79 24 MHCII MHCII NNP cord-010119-t1x9gknd 79 25 ( ( -LRB- cord-010119-t1x9gknd 79 26 OTII OTII NNP cord-010119-t1x9gknd 79 27 mice mouse NNS cord-010119-t1x9gknd 79 28 ) ) -RRB- cord-010119-t1x9gknd 79 29 . . . cord-010119-t1x9gknd 80 1 Thus thus RB cord-010119-t1x9gknd 80 2 , , , cord-010119-t1x9gknd 80 3 HOD HOD NNP cord-010119-t1x9gknd 80 4 1 1 CD cord-010119-t1x9gknd 80 5 OTII OTII NNP cord-010119-t1x9gknd 80 6 1 1 CD cord-010119-t1x9gknd 80 7 mice mouse NNS cord-010119-t1x9gknd 80 8 are be VBP cord-010119-t1x9gknd 80 9 predisposed predisposed JJ cord-010119-t1x9gknd 80 10 to to TO cord-010119-t1x9gknd 80 11 have have VB cord-010119-t1x9gknd 80 12 autoreactive autoreactive JJ cord-010119-t1x9gknd 80 13 CD4 CD4 NNP cord-010119-t1x9gknd 80 14 1 1 CD cord-010119-t1x9gknd 80 15 T T NNP cord-010119-t1x9gknd 80 16 cells cell NNS cord-010119-t1x9gknd 80 17 . . . cord-010119-t1x9gknd 81 1 Study Study NNP cord-010119-t1x9gknd 81 2 Design Design NNP cord-010119-t1x9gknd 81 3 / / SYM cord-010119-t1x9gknd 81 4 Method method NN cord-010119-t1x9gknd 81 5 : : : cord-010119-t1x9gknd 82 1 Four four CD cord-010119-t1x9gknd 82 2 cohorts cohort NNS cord-010119-t1x9gknd 82 3 of of IN cord-010119-t1x9gknd 82 4 HODxOTII hodxotii CD cord-010119-t1x9gknd 82 5 F1 F1 NNP cord-010119-t1x9gknd 82 6 mice mouse NNS cord-010119-t1x9gknd 82 7 ( ( -LRB- cord-010119-t1x9gknd 82 8 16 16 CD cord-010119-t1x9gknd 82 9 - - SYM cord-010119-t1x9gknd 82 10 48 48 CD cord-010119-t1x9gknd 82 11 mice/ mice/ CD cord-010119-t1x9gknd 82 12 cohort cohort NN cord-010119-t1x9gknd 82 13 ) ) -RRB- cord-010119-t1x9gknd 82 14 were be VBD cord-010119-t1x9gknd 82 15 bled bleed VBN cord-010119-t1x9gknd 82 16 monthly monthly RB cord-010119-t1x9gknd 82 17 for for IN cord-010119-t1x9gknd 82 18 15 15 CD cord-010119-t1x9gknd 82 19 months month NNS cord-010119-t1x9gknd 82 20 to to TO cord-010119-t1x9gknd 82 21 assess assess VB cord-010119-t1x9gknd 82 22 for for IN cord-010119-t1x9gknd 82 23 autoAb autoab CD cord-010119-t1x9gknd 82 24 production production NN cord-010119-t1x9gknd 82 25 . . . cord-010119-t1x9gknd 83 1 Peripheral peripheral JJ cord-010119-t1x9gknd 83 2 RBCs rbc NNS cord-010119-t1x9gknd 83 3 were be VBD cord-010119-t1x9gknd 83 4 stained stain VBN cord-010119-t1x9gknd 83 5 with with IN cord-010119-t1x9gknd 83 6 anti anti JJ cord-010119-t1x9gknd 83 7 - - JJ cord-010119-t1x9gknd 83 8 complement complement JJ cord-010119-t1x9gknd 83 9 ( ( -LRB- cord-010119-t1x9gknd 83 10 C3 c3 NN cord-010119-t1x9gknd 83 11 ) ) -RRB- cord-010119-t1x9gknd 83 12 and and CC cord-010119-t1x9gknd 83 13 mouse mouse NN cord-010119-t1x9gknd 83 14 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 83 15 Ab Ab NNP cord-010119-t1x9gknd 83 16 . . . cord-010119-t1x9gknd 84 1 Spleens spleen NNS cord-010119-t1x9gknd 84 2 were be VBD cord-010119-t1x9gknd 84 3 weighed weigh VBN cord-010119-t1x9gknd 84 4 and and CC cord-010119-t1x9gknd 84 5 splenocytes splenocytes NNP cord-010119-t1x9gknd 84 6 were be VBD cord-010119-t1x9gknd 84 7 stained stain VBN cord-010119-t1x9gknd 84 8 with with IN cord-010119-t1x9gknd 84 9 anti anti JJ cord-010119-t1x9gknd 84 10 - - JJ cord-010119-t1x9gknd 84 11 CD71 CD71 NNP cord-010119-t1x9gknd 84 12 and and CC cord-010119-t1x9gknd 84 13 TER119 TER119 NNP cord-010119-t1x9gknd 84 14 to to TO cord-010119-t1x9gknd 84 15 assess assess VB cord-010119-t1x9gknd 84 16 for for IN cord-010119-t1x9gknd 84 17 the the DT cord-010119-t1x9gknd 84 18 presence presence NN cord-010119-t1x9gknd 84 19 of of IN cord-010119-t1x9gknd 84 20 RBC RBC NNP cord-010119-t1x9gknd 84 21 progenitors progenitor NNS cord-010119-t1x9gknd 84 22 . . . cord-010119-t1x9gknd 85 1 Statistical statistical JJ cord-010119-t1x9gknd 85 2 analysis analysis NN cord-010119-t1x9gknd 85 3 between between IN cord-010119-t1x9gknd 85 4 HOD HOD NNP cord-010119-t1x9gknd 85 5 1 1 CD cord-010119-t1x9gknd 85 6 OTII OTII NNP cord-010119-t1x9gknd 85 7 1 1 CD cord-010119-t1x9gknd 85 8 autoAb autoab CD cord-010119-t1x9gknd 85 9 1 1 CD cord-010119-t1x9gknd 85 10 vs. vs. IN cord-010119-t1x9gknd 85 11 HOD HOD NNP cord-010119-t1x9gknd 85 12 1 1 CD cord-010119-t1x9gknd 85 13 OTII OTII NNP cord-010119-t1x9gknd 85 14 1 1 CD cord-010119-t1x9gknd 86 1 autoAbvs autoAbvs NNPS cord-010119-t1x9gknd 86 2 . . . cord-010119-t1x9gknd 87 1 HOD HOD NNP cord-010119-t1x9gknd 87 2 -OTII -OTII NNP cord-010119-t1x9gknd 87 3 1 1 CD cord-010119-t1x9gknd 87 4 was be VBD cord-010119-t1x9gknd 87 5 performed perform VBN cord-010119-t1x9gknd 87 6 using use VBG cord-010119-t1x9gknd 87 7 Kruskal Kruskal NNP cord-010119-t1x9gknd 87 8 - - HYPH cord-010119-t1x9gknd 87 9 Wallis Wallis NNP cord-010119-t1x9gknd 87 10 test test NN cord-010119-t1x9gknd 87 11 and and CC cord-010119-t1x9gknd 87 12 corrected correct VBD cord-010119-t1x9gknd 87 13 for for IN cord-010119-t1x9gknd 87 14 multiple multiple JJ cord-010119-t1x9gknd 87 15 testing testing NN cord-010119-t1x9gknd 87 16 with with IN cord-010119-t1x9gknd 87 17 Dunn Dunn NNP cord-010119-t1x9gknd 87 18 's 's POS cord-010119-t1x9gknd 87 19 test test NN cord-010119-t1x9gknd 87 20 . . . cord-010119-t1x9gknd 88 1 Results/ Results/ . cord-010119-t1x9gknd 89 1 Finding finding NN cord-010119-t1x9gknd 89 2 : : : cord-010119-t1x9gknd 90 1 OTII OTII NNP cord-010119-t1x9gknd 90 2 CD4 CD4 NNP cord-010119-t1x9gknd 90 3 1 1 CD cord-010119-t1x9gknd 90 4 T T NNP cord-010119-t1x9gknd 90 5 cells cell NNS cord-010119-t1x9gknd 90 6 were be VBD cord-010119-t1x9gknd 90 7 not not RB cord-010119-t1x9gknd 90 8 deleted delete VBN cord-010119-t1x9gknd 90 9 in in IN cord-010119-t1x9gknd 90 10 the the DT cord-010119-t1x9gknd 90 11 thymus thymus NN cord-010119-t1x9gknd 90 12 of of IN cord-010119-t1x9gknd 90 13 HOD HOD NNP cord-010119-t1x9gknd 90 14 1 1 CD cord-010119-t1x9gknd 90 15 OTII OTII NNP cord-010119-t1x9gknd 90 16 1 1 CD cord-010119-t1x9gknd 90 17 mice mouse NNS cord-010119-t1x9gknd 90 18 ; ; : cord-010119-t1x9gknd 90 19 rather rather RB cord-010119-t1x9gknd 90 20 , , , cord-010119-t1x9gknd 90 21 they -PRON- PRP cord-010119-t1x9gknd 90 22 matured mature VBD cord-010119-t1x9gknd 90 23 to to IN cord-010119-t1x9gknd 90 24 the the DT cord-010119-t1x9gknd 90 25 periphery periphery NN cord-010119-t1x9gknd 90 26 . . . cord-010119-t1x9gknd 91 1 Despite despite IN cord-010119-t1x9gknd 91 2 these these DT cord-010119-t1x9gknd 91 3 peripheral peripheral JJ cord-010119-t1x9gknd 91 4 autoreactive autoreactive JJ cord-010119-t1x9gknd 91 5 T t NN cord-010119-t1x9gknd 91 6 cells cell NNS cord-010119-t1x9gknd 91 7 , , , cord-010119-t1x9gknd 91 8 no no DT cord-010119-t1x9gknd 91 9 detectable detectable JJ cord-010119-t1x9gknd 91 10 autoAb autoAb NNS cord-010119-t1x9gknd 91 11 were be VBD cord-010119-t1x9gknd 91 12 observed observe VBN cord-010119-t1x9gknd 91 13 in in IN cord-010119-t1x9gknd 91 14 HOD HOD NNP cord-010119-t1x9gknd 91 15 1 1 CD cord-010119-t1x9gknd 91 16 OTII OTII NNP cord-010119-t1x9gknd 91 17 1 1 CD cord-010119-t1x9gknd 91 18 . . . cord-010119-t1x9gknd 92 1 However however RB cord-010119-t1x9gknd 92 2 , , , cord-010119-t1x9gknd 92 3 as as IN cord-010119-t1x9gknd 92 4 they -PRON- PRP cord-010119-t1x9gknd 92 5 aged age VBN cord-010119-t1x9gknd 92 6 , , , cord-010119-t1x9gknd 92 7 15 15 CD cord-010119-t1x9gknd 92 8 - - SYM cord-010119-t1x9gknd 92 9 50 50 CD cord-010119-t1x9gknd 92 10 % % NN cord-010119-t1x9gknd 92 11 of of IN cord-010119-t1x9gknd 92 12 HOD HOD NNP cord-010119-t1x9gknd 92 13 1 1 CD cord-010119-t1x9gknd 92 14 OTII OTII NNP cord-010119-t1x9gknd 92 15 1 1 CD cord-010119-t1x9gknd 92 16 were be VBD cord-010119-t1x9gknd 92 17 positive positive JJ cord-010119-t1x9gknd 92 18 for for IN cord-010119-t1x9gknd 92 19 RBC RBC NNP cord-010119-t1x9gknd 92 20 autoAb autoAb NNP cord-010119-t1x9gknd 92 21 by by IN cord-010119-t1x9gknd 92 22 6 6 CD cord-010119-t1x9gknd 92 23 months month NNS cord-010119-t1x9gknd 92 24 . . . cord-010119-t1x9gknd 93 1 Thereafter thereafter RB cord-010119-t1x9gknd 93 2 , , , cord-010119-t1x9gknd 93 3 $ $ $ cord-010119-t1x9gknd 93 4 50 50 CD cord-010119-t1x9gknd 93 5 % % NN cord-010119-t1x9gknd 93 6 of of IN cord-010119-t1x9gknd 93 7 the the DT cord-010119-t1x9gknd 93 8 autoAb autoab CD cord-010119-t1x9gknd 93 9 1 1 CD cord-010119-t1x9gknd 93 10 mice mouse NNS cord-010119-t1x9gknd 93 11 stopped stop VBD cord-010119-t1x9gknd 93 12 producing produce VBG cord-010119-t1x9gknd 93 13 autoAb autoAb NNP cord-010119-t1x9gknd 93 14 within within IN cord-010119-t1x9gknd 93 15 two two CD cord-010119-t1x9gknd 93 16 months month NNS cord-010119-t1x9gknd 93 17 after after IN cord-010119-t1x9gknd 93 18 onset onset NN cord-010119-t1x9gknd 93 19 and and CC cord-010119-t1x9gknd 93 20 remained remain VBD cord-010119-t1x9gknd 93 21 autoAb autoAb NNP cord-010119-t1x9gknd 93 22 free free JJ cord-010119-t1x9gknd 93 23 throughout throughout IN cord-010119-t1x9gknd 93 24 the the DT cord-010119-t1x9gknd 93 25 study study NN cord-010119-t1x9gknd 93 26 . . . cord-010119-t1x9gknd 94 1 In in IN cord-010119-t1x9gknd 94 2 3 3 CD cord-010119-t1x9gknd 94 3 of of IN cord-010119-t1x9gknd 94 4 the the DT cord-010119-t1x9gknd 94 5 4 4 CD cord-010119-t1x9gknd 94 6 cohorts cohort NNS cord-010119-t1x9gknd 94 7 , , , cord-010119-t1x9gknd 94 8 60 60 CD cord-010119-t1x9gknd 94 9 - - SYM cord-010119-t1x9gknd 94 10 100 100 CD cord-010119-t1x9gknd 94 11 % % NN cord-010119-t1x9gknd 94 12 of of IN cord-010119-t1x9gknd 94 13 autoAb autoAb NNP cord-010119-t1x9gknd 94 14 1 1 CD cord-010119-t1x9gknd 94 15 mice mouse NNS cord-010119-t1x9gknd 94 16 were be VBD cord-010119-t1x9gknd 94 17 female female JJ cord-010119-t1x9gknd 94 18 . . . cord-010119-t1x9gknd 95 1 HOD HOD NNP cord-010119-t1x9gknd 95 2 1 1 CD cord-010119-t1x9gknd 96 1 OTII OTII NNP cord-010119-t1x9gknd 96 2 1 1 CD cord-010119-t1x9gknd 96 3 autoAb autoab CD cord-010119-t1x9gknd 96 4 1 1 CD cord-010119-t1x9gknd 96 5 mice mouse NNS cord-010119-t1x9gknd 96 6 also also RB cord-010119-t1x9gknd 96 7 had have VBD cord-010119-t1x9gknd 96 8 enlarged enlarge VBN cord-010119-t1x9gknd 96 9 spleens spleen NNS cord-010119-t1x9gknd 96 10 compared compare VBN cord-010119-t1x9gknd 96 11 to to IN cord-010119-t1x9gknd 96 12 HOD HOD NNP cord-010119-t1x9gknd 96 13 1 1 CD cord-010119-t1x9gknd 96 14 OTII OTII NNP cord-010119-t1x9gknd 96 15 1 1 CD cord-010119-t1x9gknd 96 16 autoAband autoaband CC cord-010119-t1x9gknd 96 17 HOD HOD NNP cord-010119-t1x9gknd 96 18 -OTII -otii NN cord-010119-t1x9gknd 96 19 1 1 CD cord-010119-t1x9gknd 96 20 mice mice NN cord-010119-t1x9gknd 96 21 ( ( -LRB- cord-010119-t1x9gknd 96 22 0.42 0.42 CD cord-010119-t1x9gknd 96 23 g g NN cord-010119-t1x9gknd 96 24 vs. vs. FW cord-010119-t1x9gknd 96 25 0.21 0.21 CD cord-010119-t1x9gknd 96 26 g g NN cord-010119-t1x9gknd 96 27 and and CC cord-010119-t1x9gknd 96 28 0.14 0.14 CD cord-010119-t1x9gknd 96 29 g g NN cord-010119-t1x9gknd 96 30 , , , cord-010119-t1x9gknd 96 31 resp resp NNP cord-010119-t1x9gknd 96 32 . . NNP cord-010119-t1x9gknd 96 33 , , , cord-010119-t1x9gknd 96 34 p<0.04 p<0.04 NN cord-010119-t1x9gknd 96 35 ) ) -RRB- cord-010119-t1x9gknd 96 36 . . . cord-010119-t1x9gknd 97 1 This this DT cord-010119-t1x9gknd 97 2 may may MD cord-010119-t1x9gknd 97 3 due due IN cord-010119-t1x9gknd 97 4 to to IN cord-010119-t1x9gknd 97 5 RBC RBC NNP cord-010119-t1x9gknd 97 6 consumption consumption NN cord-010119-t1x9gknd 97 7 , , , cord-010119-t1x9gknd 97 8 extramedullary extramedullary NNP cord-010119-t1x9gknd 97 9 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 97 10 , , , cord-010119-t1x9gknd 97 11 or or CC cord-010119-t1x9gknd 97 12 both both DT cord-010119-t1x9gknd 97 13 . . . cord-010119-t1x9gknd 98 1 Consistent consistent JJ cord-010119-t1x9gknd 98 2 with with IN cord-010119-t1x9gknd 98 3 increased increase VBN cord-010119-t1x9gknd 98 4 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 98 5 , , , cord-010119-t1x9gknd 98 6 elevated elevated JJ cord-010119-t1x9gknd 98 7 numbers number NNS cord-010119-t1x9gknd 98 8 of of IN cord-010119-t1x9gknd 98 9 RBC RBC NNP cord-010119-t1x9gknd 98 10 progenitors progenitor NNS cord-010119-t1x9gknd 98 11 ( ( -LRB- cord-010119-t1x9gknd 98 12 CD71 CD71 NNP cord-010119-t1x9gknd 98 13 hi hi UH cord-010119-t1x9gknd 98 14 Ter119 Ter119 NNP cord-010119-t1x9gknd 98 15 inter inter NNP cord-010119-t1x9gknd 98 16 ) ) -RRB- cord-010119-t1x9gknd 98 17 were be VBD cord-010119-t1x9gknd 98 18 observed observe VBN cord-010119-t1x9gknd 98 19 in in IN cord-010119-t1x9gknd 98 20 the the DT cord-010119-t1x9gknd 98 21 spleens spleen NNS cord-010119-t1x9gknd 98 22 of of IN cord-010119-t1x9gknd 98 23 HOD HOD NNP cord-010119-t1x9gknd 98 24 1 1 CD cord-010119-t1x9gknd 98 25 OTII OTII NNP cord-010119-t1x9gknd 98 26 1 1 CD cord-010119-t1x9gknd 98 27 autoAb autoab CD cord-010119-t1x9gknd 98 28 1 1 CD cord-010119-t1x9gknd 98 29 mice mouse NNS cord-010119-t1x9gknd 98 30 but but CC cord-010119-t1x9gknd 98 31 not not RB cord-010119-t1x9gknd 98 32 in in IN cord-010119-t1x9gknd 98 33 HOD HOD NNP cord-010119-t1x9gknd 98 34 1 1 CD cord-010119-t1x9gknd 98 35 OTII OTII NNP cord-010119-t1x9gknd 98 36 1 1 CD cord-010119-t1x9gknd 98 37 autoAband autoaband CC cord-010119-t1x9gknd 98 38 HOD HOD NNP cord-010119-t1x9gknd 99 1 -OTII -OTII NNP cord-010119-t1x9gknd 99 2 1 1 CD cord-010119-t1x9gknd 100 1 ( ( -LRB- cord-010119-t1x9gknd 100 2 2.86 2.86 CD cord-010119-t1x9gknd 100 3 % % NN cord-010119-t1x9gknd 100 4 vs. vs. CC cord-010119-t1x9gknd 100 5 0.06 0.06 CD cord-010119-t1x9gknd 100 6 % % NN cord-010119-t1x9gknd 100 7 and and CC cord-010119-t1x9gknd 100 8 0.05 0.05 CD cord-010119-t1x9gknd 100 9 % % NN cord-010119-t1x9gknd 100 10 resp resp NN cord-010119-t1x9gknd 100 11 . . NNP cord-010119-t1x9gknd 100 12 , , , cord-010119-t1x9gknd 101 1 p<0.03 p<0.03 NNP cord-010119-t1x9gknd 101 2 ) ) -RRB- cord-010119-t1x9gknd 101 3 . . . cord-010119-t1x9gknd 102 1 Moreover moreover RB cord-010119-t1x9gknd 102 2 , , , cord-010119-t1x9gknd 102 3 autoAb autoAb NNP cord-010119-t1x9gknd 102 4 and and CC cord-010119-t1x9gknd 102 5 C3 C3 NNP cord-010119-t1x9gknd 102 6 deposition deposition NN cord-010119-t1x9gknd 102 7 were be VBD cord-010119-t1x9gknd 102 8 found find VBN cord-010119-t1x9gknd 102 9 ( ( -LRB- cord-010119-t1x9gknd 102 10 0.1 0.1 CD cord-010119-t1x9gknd 102 11 - - SYM cord-010119-t1x9gknd 102 12 2 2 CD cord-010119-t1x9gknd 102 13 % % NN cord-010119-t1x9gknd 102 14 and and CC cord-010119-t1x9gknd 102 15 3 3 CD cord-010119-t1x9gknd 102 16 - - SYM cord-010119-t1x9gknd 102 17 10 10 CD cord-010119-t1x9gknd 102 18 % % NN cord-010119-t1x9gknd 102 19 , , , cord-010119-t1x9gknd 102 20 resp resp NNP cord-010119-t1x9gknd 102 21 . . . cord-010119-t1x9gknd 102 22 ) ) -RRB- cord-010119-t1x9gknd 103 1 on on IN cord-010119-t1x9gknd 103 2 Ter119 ter119 CD cord-010119-t1x9gknd 103 3 1 1 CD cord-010119-t1x9gknd 103 4 RBCs rbc NNS cord-010119-t1x9gknd 103 5 in in IN cord-010119-t1x9gknd 103 6 all all DT cord-010119-t1x9gknd 103 7 of of IN cord-010119-t1x9gknd 103 8 the the DT cord-010119-t1x9gknd 103 9 HOD HOD NNP cord-010119-t1x9gknd 103 10 1 1 CD cord-010119-t1x9gknd 103 11 OTII OTII NNP cord-010119-t1x9gknd 103 12 1 1 CD cord-010119-t1x9gknd 103 13 autoAb autoab CD cord-010119-t1x9gknd 103 14 1 1 CD cord-010119-t1x9gknd 103 15 mice mouse NNS cord-010119-t1x9gknd 103 16 analyzed analyze VBN cord-010119-t1x9gknd 103 17 . . . cord-010119-t1x9gknd 104 1 Conclusion conclusion NN cord-010119-t1x9gknd 104 2 : : : cord-010119-t1x9gknd 105 1 Several several JJ cord-010119-t1x9gknd 105 2 features feature NNS cord-010119-t1x9gknd 105 3 known know VBN cord-010119-t1x9gknd 105 4 to to TO cord-010119-t1x9gknd 105 5 exist exist VB cord-010119-t1x9gknd 105 6 in in IN cord-010119-t1x9gknd 105 7 human human JJ cord-010119-t1x9gknd 105 8 AIHA AIHA NNP cord-010119-t1x9gknd 105 9 were be VBD cord-010119-t1x9gknd 105 10 observed observe VBN cord-010119-t1x9gknd 105 11 , , , cord-010119-t1x9gknd 105 12 including include VBG cord-010119-t1x9gknd 105 13 age age NN cord-010119-t1x9gknd 105 14 - - HYPH cord-010119-t1x9gknd 105 15 dependant dependant JJ cord-010119-t1x9gknd 105 16 autoAb autoab CD cord-010119-t1x9gknd 105 17 production production NN cord-010119-t1x9gknd 105 18 , , , cord-010119-t1x9gknd 105 19 relapsing relapse VBG cord-010119-t1x9gknd 105 20 of of IN cord-010119-t1x9gknd 105 21 autoimmunity autoimmunity NN cord-010119-t1x9gknd 105 22 after after IN cord-010119-t1x9gknd 105 23 onset onset NN cord-010119-t1x9gknd 105 24 , , , cord-010119-t1x9gknd 105 25 and and CC cord-010119-t1x9gknd 105 26 an an DT cord-010119-t1x9gknd 105 27 increased increase VBN cord-010119-t1x9gknd 105 28 frequency frequency NN cord-010119-t1x9gknd 105 29 in in IN cord-010119-t1x9gknd 105 30 females female NNS cord-010119-t1x9gknd 105 31 . . . cord-010119-t1x9gknd 106 1 This this DT cord-010119-t1x9gknd 106 2 model model NN cord-010119-t1x9gknd 106 3 may may MD cord-010119-t1x9gknd 106 4 serve serve VB cord-010119-t1x9gknd 106 5 as as IN cord-010119-t1x9gknd 106 6 an an DT cord-010119-t1x9gknd 106 7 experimental experimental JJ cord-010119-t1x9gknd 106 8 system system NN cord-010119-t1x9gknd 106 9 to to TO cord-010119-t1x9gknd 106 10 investigate investigate VB cord-010119-t1x9gknd 106 11 the the DT cord-010119-t1x9gknd 106 12 mechanisms mechanism NNS cord-010119-t1x9gknd 106 13 of of IN cord-010119-t1x9gknd 106 14 AIHA AIHA NNP cord-010119-t1x9gknd 106 15 . . . cord-010119-t1x9gknd 107 1 B5-A01A B5-A01A NNP cord-010119-t1x9gknd 107 2 Reduction Reduction NNP cord-010119-t1x9gknd 107 3 in in IN cord-010119-t1x9gknd 107 4 Neutrophil Neutrophil NNP cord-010119-t1x9gknd 107 5 Numbers Numbers NNPS cord-010119-t1x9gknd 107 6 Is be VBZ cord-010119-t1x9gknd 107 7 a a DT cord-010119-t1x9gknd 107 8 Risk Risk NNP cord-010119-t1x9gknd 107 9 Factor Factor NNP cord-010119-t1x9gknd 107 10 for for IN cord-010119-t1x9gknd 107 11 RBC RBC NNP cord-010119-t1x9gknd 107 12 Alloimmunization Alloimmunization NNP cord-010119-t1x9gknd 107 13 Amanda Amanda NNP cord-010119-t1x9gknd 107 14 L L NNP cord-010119-t1x9gknd 107 15 Richards Richards NNP cord-010119-t1x9gknd 107 16 1 1 CD cord-010119-t1x9gknd 107 17 , , , cord-010119-t1x9gknd 107 18 Christopher Christopher NNP cord-010119-t1x9gknd 107 19 A A NNP cord-010119-t1x9gknd 107 20 Tormey Tormey NNP cord-010119-t1x9gknd 107 21 2 2 CD cord-010119-t1x9gknd 107 22 and and CC cord-010119-t1x9gknd 107 23 Krystalyn Krystalyn NNP cord-010119-t1x9gknd 107 24 E E NNP cord-010119-t1x9gknd 107 25 Hudson Hudson NNP cord-010119-t1x9gknd 108 1 * * NFP cord-010119-t1x9gknd 108 2 1 1 CD cord-010119-t1x9gknd 108 3 . . . cord-010119-t1x9gknd 109 1 Background Background NNP cord-010119-t1x9gknd 109 2 / / SYM cord-010119-t1x9gknd 109 3 Case Case NNP cord-010119-t1x9gknd 109 4 Studies Studies NNPS cord-010119-t1x9gknd 109 5 : : : cord-010119-t1x9gknd 110 1 Red red JJ cord-010119-t1x9gknd 110 2 blood blood NN cord-010119-t1x9gknd 110 3 cell cell NN cord-010119-t1x9gknd 110 4 ( ( -LRB- cord-010119-t1x9gknd 110 5 RBC RBC NNP cord-010119-t1x9gknd 110 6 ) ) -RRB- cord-010119-t1x9gknd 110 7 alloimmunization alloimmunization NN cord-010119-t1x9gknd 110 8 occurs occur VBZ cord-010119-t1x9gknd 110 9 in in IN cord-010119-t1x9gknd 110 10 up up IN cord-010119-t1x9gknd 110 11 to to TO cord-010119-t1x9gknd 110 12 10 10 CD cord-010119-t1x9gknd 110 13 % % NN cord-010119-t1x9gknd 110 14 of of IN cord-010119-t1x9gknd 110 15 transfusion transfusion NN cord-010119-t1x9gknd 110 16 recipients recipient NNS cord-010119-t1x9gknd 110 17 ( ( -LRB- cord-010119-t1x9gknd 110 18 excluding exclude VBG cord-010119-t1x9gknd 110 19 ABO ABO NNP cord-010119-t1x9gknd 110 20 and and CC cord-010119-t1x9gknd 110 21 RhD RhD NNP cord-010119-t1x9gknd 110 22 ) ) -RRB- cord-010119-t1x9gknd 110 23 . . . cord-010119-t1x9gknd 111 1 The the DT cord-010119-t1x9gknd 111 2 underlying underlying JJ cord-010119-t1x9gknd 111 3 factors factor NNS cord-010119-t1x9gknd 111 4 that that WDT cord-010119-t1x9gknd 111 5 influence influence VBP cord-010119-t1x9gknd 111 6 alloimmunization alloimmunization NN cord-010119-t1x9gknd 111 7 are be VBP cord-010119-t1x9gknd 111 8 poorly poorly RB cord-010119-t1x9gknd 111 9 understood understand VBN cord-010119-t1x9gknd 111 10 ; ; : cord-010119-t1x9gknd 111 11 thus thus RB cord-010119-t1x9gknd 111 12 , , , cord-010119-t1x9gknd 111 13 there there EX cord-010119-t1x9gknd 111 14 is be VBZ cord-010119-t1x9gknd 111 15 currently currently RB cord-010119-t1x9gknd 111 16 no no DT cord-010119-t1x9gknd 111 17 reliable reliable JJ cord-010119-t1x9gknd 111 18 way way NN cord-010119-t1x9gknd 111 19 to to TO cord-010119-t1x9gknd 111 20 predict predict VB cord-010119-t1x9gknd 111 21 who who WP cord-010119-t1x9gknd 111 22 will will MD cord-010119-t1x9gknd 111 23 make make VB cord-010119-t1x9gknd 111 24 an an DT cord-010119-t1x9gknd 111 25 alloantibody alloantibody NN cord-010119-t1x9gknd 111 26 and and CC cord-010119-t1x9gknd 111 27 who who WP cord-010119-t1x9gknd 111 28 will will MD cord-010119-t1x9gknd 111 29 not not RB cord-010119-t1x9gknd 111 30 . . . cord-010119-t1x9gknd 112 1 Patients patient NNS cord-010119-t1x9gknd 112 2 who who WP cord-010119-t1x9gknd 112 3 receive receive VBP cord-010119-t1x9gknd 112 4 multiple multiple JJ cord-010119-t1x9gknd 112 5 RBC RBC NNP cord-010119-t1x9gknd 112 6 units unit NNS cord-010119-t1x9gknd 112 7 or or CC cord-010119-t1x9gknd 112 8 several several JJ cord-010119-t1x9gknd 112 9 separate separate JJ cord-010119-t1x9gknd 112 10 transfusions transfusion NNS cord-010119-t1x9gknd 112 11 are be VBP cord-010119-t1x9gknd 112 12 at at IN cord-010119-t1x9gknd 112 13 higher high JJR cord-010119-t1x9gknd 112 14 risk risk NN cord-010119-t1x9gknd 112 15 of of IN cord-010119-t1x9gknd 112 16 alloimmunization alloimmunization NN cord-010119-t1x9gknd 112 17 ; ; : cord-010119-t1x9gknd 112 18 likewise likewise RB cord-010119-t1x9gknd 112 19 , , , cord-010119-t1x9gknd 112 20 certain certain JJ cord-010119-t1x9gknd 112 21 disease disease NN cord-010119-t1x9gknd 112 22 states state NNS cord-010119-t1x9gknd 112 23 have have VBP cord-010119-t1x9gknd 112 24 higher high JJR cord-010119-t1x9gknd 112 25 rates rate NNS cord-010119-t1x9gknd 112 26 of of IN cord-010119-t1x9gknd 112 27 alloimmunization alloimmunization NN cord-010119-t1x9gknd 112 28 , , , cord-010119-t1x9gknd 112 29 such such JJ cord-010119-t1x9gknd 112 30 as as IN cord-010119-t1x9gknd 112 31 myelodysplasctic myelodysplasctic JJ cord-010119-t1x9gknd 112 32 syndrome syndrome NN cord-010119-t1x9gknd 112 33 ( ( -LRB- cord-010119-t1x9gknd 112 34 MDS MDS NNP cord-010119-t1x9gknd 112 35 ) ) -RRB- cord-010119-t1x9gknd 112 36 and and CC cord-010119-t1x9gknd 112 37 sickle sickle NN cord-010119-t1x9gknd 112 38 cell cell NN cord-010119-t1x9gknd 112 39 disease disease NN cord-010119-t1x9gknd 112 40 patients patient NNS cord-010119-t1x9gknd 112 41 . . . cord-010119-t1x9gknd 113 1 However however RB cord-010119-t1x9gknd 113 2 , , , cord-010119-t1x9gknd 113 3 despite despite IN cord-010119-t1x9gknd 113 4 chronic chronic JJ cord-010119-t1x9gknd 113 5 transfusions transfusion NNS cord-010119-t1x9gknd 113 6 , , , cord-010119-t1x9gknd 113 7 some some DT cord-010119-t1x9gknd 113 8 patients patient NNS cord-010119-t1x9gknd 113 9 never never RB cord-010119-t1x9gknd 113 10 develop develop VBP cord-010119-t1x9gknd 113 11 RBC RBC NNP cord-010119-t1x9gknd 113 12 alloantibodies alloantibody NNS cord-010119-t1x9gknd 113 13 . . . cord-010119-t1x9gknd 114 1 It -PRON- PRP cord-010119-t1x9gknd 114 2 has have VBZ cord-010119-t1x9gknd 114 3 been be VBN cord-010119-t1x9gknd 114 4 recently recently RB cord-010119-t1x9gknd 114 5 reported report VBN cord-010119-t1x9gknd 114 6 that that IN cord-010119-t1x9gknd 114 7 poly poly NN cord-010119-t1x9gknd 114 8 ( ( -LRB- cord-010119-t1x9gknd 114 9 I i NN cord-010119-t1x9gknd 114 10 : : : cord-010119-t1x9gknd 114 11 C)-elicited c)-elicited JJ cord-010119-t1x9gknd 114 12 inflammation inflammation NN cord-010119-t1x9gknd 114 13 leads lead VBZ cord-010119-t1x9gknd 114 14 to to IN cord-010119-t1x9gknd 114 15 enhanced enhance VBN cord-010119-t1x9gknd 114 16 alloimmunization alloimmunization NN cord-010119-t1x9gknd 114 17 rates rate NNS cord-010119-t1x9gknd 114 18 and and CC cord-010119-t1x9gknd 114 19 is be VBZ cord-010119-t1x9gknd 114 20 correlated correlate VBN cord-010119-t1x9gknd 114 21 with with IN cord-010119-t1x9gknd 114 22 increased increase VBN cord-010119-t1x9gknd 114 23 splenic splenic JJ cord-010119-t1x9gknd 114 24 neutrophil neutrophil NN cord-010119-t1x9gknd 114 25 ( ( -LRB- cord-010119-t1x9gknd 114 26 PMN PMN NNP cord-010119-t1x9gknd 114 27 ) ) -RRB- cord-010119-t1x9gknd 114 28 numbers number NNS cord-010119-t1x9gknd 114 29 . . . cord-010119-t1x9gknd 115 1 Additionally additionally RB cord-010119-t1x9gknd 115 2 , , , cord-010119-t1x9gknd 115 3 RBC RBC NNP cord-010119-t1x9gknd 115 4 transfusion transfusion NN cord-010119-t1x9gknd 115 5 into into IN cord-010119-t1x9gknd 115 6 an an DT cord-010119-t1x9gknd 115 7 inflamed inflamed JJ cord-010119-t1x9gknd 115 8 recipient recipient NN cord-010119-t1x9gknd 115 9 leads lead VBZ cord-010119-t1x9gknd 115 10 to to IN cord-010119-t1x9gknd 115 11 enhanced enhance VBN cord-010119-t1x9gknd 115 12 erythrophagocytosis erythrophagocytosis NN cord-010119-t1x9gknd 115 13 by by IN cord-010119-t1x9gknd 115 14 PMNs pmn NNS cord-010119-t1x9gknd 115 15 . . . cord-010119-t1x9gknd 116 1 Here here RB cord-010119-t1x9gknd 116 2 , , , cord-010119-t1x9gknd 116 3 we -PRON- PRP cord-010119-t1x9gknd 116 4 test test VBP cord-010119-t1x9gknd 116 5 the the DT cord-010119-t1x9gknd 116 6 hypothesis hypothesis NN cord-010119-t1x9gknd 116 7 that that WDT cord-010119-t1x9gknd 116 8 PMNs pmn NNS cord-010119-t1x9gknd 116 9 regulate regulate VBP cord-010119-t1x9gknd 116 10 RBC RBC NNP cord-010119-t1x9gknd 116 11 alloantibody alloantibody NN cord-010119-t1x9gknd 116 12 generation generation NN cord-010119-t1x9gknd 116 13 . . . cord-010119-t1x9gknd 117 1 Study Study NNP cord-010119-t1x9gknd 117 2 Design Design NNP cord-010119-t1x9gknd 117 3 / / SYM cord-010119-t1x9gknd 117 4 Method method NN cord-010119-t1x9gknd 117 5 : : : cord-010119-t1x9gknd 117 6 Mice mice NN cord-010119-t1x9gknd 117 7 : : : cord-010119-t1x9gknd 117 8 C57Bl/6 C57Bl/6 NNS cord-010119-t1x9gknd 117 9 ( ( -LRB- cord-010119-t1x9gknd 117 10 B6 b6 NN cord-010119-t1x9gknd 117 11 ) ) -RRB- cord-010119-t1x9gknd 118 1 mice mouse NNS cord-010119-t1x9gknd 118 2 were be VBD cord-010119-t1x9gknd 118 3 treated treat VBN cord-010119-t1x9gknd 118 4 with with IN cord-010119-t1x9gknd 118 5 PBS PBS NNP cord-010119-t1x9gknd 118 6 , , , cord-010119-t1x9gknd 118 7 or or CC cord-010119-t1x9gknd 118 8 anti anti JJ cord-010119-t1x9gknd 118 9 - - JJ cord-010119-t1x9gknd 118 10 Ly6 ly6 JJ cord-010119-t1x9gknd 118 11 G g NN cord-010119-t1x9gknd 118 12 to to TO cord-010119-t1x9gknd 118 13 deplete deplete VB cord-010119-t1x9gknd 118 14 PMNs pmn NNS cord-010119-t1x9gknd 118 15 , , , cord-010119-t1x9gknd 118 16 followed follow VBN cord-010119-t1x9gknd 118 17 by by IN cord-010119-t1x9gknd 118 18 poly poly NNP cord-010119-t1x9gknd 118 19 ( ( -LRB- cord-010119-t1x9gknd 118 20 I i NN cord-010119-t1x9gknd 118 21 : : : cord-010119-t1x9gknd 118 22 C C NNP cord-010119-t1x9gknd 118 23 ) ) -RRB- cord-010119-t1x9gknd 118 24 to to TO cord-010119-t1x9gknd 118 25 elicit elicit VB cord-010119-t1x9gknd 118 26 inflammation inflammation NN cord-010119-t1x9gknd 118 27 , , , cord-010119-t1x9gknd 118 28 and and CC cord-010119-t1x9gknd 118 29 finally finally RB cord-010119-t1x9gknd 118 30 a a DT cord-010119-t1x9gknd 118 31 transfusion transfusion NN cord-010119-t1x9gknd 118 32 of of IN cord-010119-t1x9gknd 118 33 allogeneic allogeneic NN cord-010119-t1x9gknd 118 34 DiO dio NN cord-010119-t1x9gknd 118 35 - - HYPH cord-010119-t1x9gknd 118 36 labeled label VBN cord-010119-t1x9gknd 118 37 RBCs rbc NNS cord-010119-t1x9gknd 118 38 expressing express VBG cord-010119-t1x9gknd 118 39 a a DT cord-010119-t1x9gknd 118 40 synthetic synthetic JJ cord-010119-t1x9gknd 118 41 antigen antigen NN cord-010119-t1x9gknd 118 42 , , , cord-010119-t1x9gknd 118 43 HOD HOD NNP cord-010119-t1x9gknd 118 44 ( ( -LRB- cord-010119-t1x9gknd 118 45 HEL HEL NNP cord-010119-t1x9gknd 118 46 - - HYPH cord-010119-t1x9gknd 118 47 OVA OVA NNP cord-010119-t1x9gknd 118 48 - - HYPH cord-010119-t1x9gknd 118 49 Duffy Duffy NNP cord-010119-t1x9gknd 118 50 ) ) -RRB- cord-010119-t1x9gknd 118 51 . . . cord-010119-t1x9gknd 119 1 Multiple multiple JJ cord-010119-t1x9gknd 119 2 splenic splenic JJ cord-010119-t1x9gknd 119 3 cellular cellular JJ cord-010119-t1x9gknd 119 4 subsets subset NNS cord-010119-t1x9gknd 119 5 were be VBD cord-010119-t1x9gknd 119 6 evaluated evaluate VBN cord-010119-t1x9gknd 119 7 for for IN cord-010119-t1x9gknd 119 8 DiO dio NN cord-010119-t1x9gknd 119 9 fluorescence fluorescence NN cord-010119-t1x9gknd 119 10 , , , cord-010119-t1x9gknd 119 11 an an DT cord-010119-t1x9gknd 119 12 indirect indirect JJ cord-010119-t1x9gknd 119 13 measure measure NN cord-010119-t1x9gknd 119 14 of of IN cord-010119-t1x9gknd 119 15 RBC RBC NNP cord-010119-t1x9gknd 119 16 consumption consumption NN cord-010119-t1x9gknd 119 17 , , , cord-010119-t1x9gknd 119 18 at at IN cord-010119-t1x9gknd 119 19 18 18 CD cord-010119-t1x9gknd 119 20 - - SYM cord-010119-t1x9gknd 119 21 24 24 CD cord-010119-t1x9gknd 119 22 hours hour NNS cord-010119-t1x9gknd 119 23 post post NN cord-010119-t1x9gknd 119 24 - - NN cord-010119-t1x9gknd 119 25 transfusion transfusion NN cord-010119-t1x9gknd 119 26 . . . cord-010119-t1x9gknd 120 1 Anti Anti NNP cord-010119-t1x9gknd 120 2 - - NNP cord-010119-t1x9gknd 120 3 HOD HOD NNP cord-010119-t1x9gknd 120 4 alloantibody alloantibody NN cord-010119-t1x9gknd 120 5 generation generation NN cord-010119-t1x9gknd 120 6 was be VBD cord-010119-t1x9gknd 120 7 assessed assess VBN cord-010119-t1x9gknd 120 8 14 14 CD cord-010119-t1x9gknd 120 9 days day NNS cord-010119-t1x9gknd 120 10 post post NN cord-010119-t1x9gknd 120 11 - - JJ cord-010119-t1x9gknd 120 12 transfusion transfusion NN cord-010119-t1x9gknd 120 13 by by IN cord-010119-t1x9gknd 120 14 flow flow NN cord-010119-t1x9gknd 120 15 cytometry cytometry NN cord-010119-t1x9gknd 120 16 . . . cord-010119-t1x9gknd 121 1 Humans human NNS cord-010119-t1x9gknd 121 2 : : : cord-010119-t1x9gknd 122 1 Retrospectively retrospectively RB cord-010119-t1x9gknd 122 2 , , , cord-010119-t1x9gknd 122 3 mean mean VBP cord-010119-t1x9gknd 122 4 white white JJ cord-010119-t1x9gknd 122 5 blood blood NN cord-010119-t1x9gknd 122 6 cell cell NN cord-010119-t1x9gknd 122 7 ( ( -LRB- cord-010119-t1x9gknd 122 8 WBC WBC NNP cord-010119-t1x9gknd 122 9 ) ) -RRB- cord-010119-t1x9gknd 122 10 and and CC cord-010119-t1x9gknd 122 11 PMN PMN NNP cord-010119-t1x9gknd 122 12 counts count NNS cord-010119-t1x9gknd 122 13 were be VBD cord-010119-t1x9gknd 122 14 collected collect VBN cord-010119-t1x9gknd 122 15 on on IN cord-010119-t1x9gknd 122 16 chronically chronically RB cord-010119-t1x9gknd 122 17 transfused transfuse VBN cord-010119-t1x9gknd 122 18 MDS MDS NNP cord-010119-t1x9gknd 122 19 patients patient NNS cord-010119-t1x9gknd 122 20 at at IN cord-010119-t1x9gknd 122 21 VA VA NNP cord-010119-t1x9gknd 122 22 Connecticut Connecticut NNP cord-010119-t1x9gknd 122 23 Healthcare Healthcare NNP cord-010119-t1x9gknd 122 24 . . . cord-010119-t1x9gknd 123 1 For for IN cord-010119-t1x9gknd 123 2 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 123 3 patients patient NNS cord-010119-t1x9gknd 123 4 ( ( -LRB- cord-010119-t1x9gknd 123 5 n55 n55 NNP cord-010119-t1x9gknd 123 6 ) ) -RRB- cord-010119-t1x9gknd 123 7 , , , cord-010119-t1x9gknd 123 8 WBC WBC NNP cord-010119-t1x9gknd 123 9 and and CC cord-010119-t1x9gknd 123 10 PMN PMN NNP cord-010119-t1x9gknd 123 11 counts count NNS cord-010119-t1x9gknd 123 12 were be VBD cord-010119-t1x9gknd 123 13 assessed assess VBN cord-010119-t1x9gknd 123 14 on on IN cord-010119-t1x9gknd 123 15 the the DT cord-010119-t1x9gknd 123 16 day day NN cord-010119-t1x9gknd 123 17 of of IN cord-010119-t1x9gknd 123 18 exposure exposure NN cord-010119-t1x9gknd 123 19 to to IN cord-010119-t1x9gknd 123 20 the the DT cord-010119-t1x9gknd 123 21 alloimmunizing alloimmunize VBG cord-010119-t1x9gknd 123 22 RBC RBC NNP cord-010119-t1x9gknd 123 23 unit unit NN cord-010119-t1x9gknd 123 24 , , , cord-010119-t1x9gknd 123 25 whereas whereas IN cord-010119-t1x9gknd 123 26 counts count NNS cord-010119-t1x9gknd 123 27 were be VBD cord-010119-t1x9gknd 123 28 averaged average VBN cord-010119-t1x9gknd 123 29 for for IN cord-010119-t1x9gknd 123 30 the the DT cord-010119-t1x9gknd 123 31 entirety entirety NN cord-010119-t1x9gknd 123 32 of of IN cord-010119-t1x9gknd 123 33 RBC RBC NNP cord-010119-t1x9gknd 123 34 therapy therapy NN cord-010119-t1x9gknd 123 35 for for IN cord-010119-t1x9gknd 123 36 non non JJ cord-010119-t1x9gknd 123 37 - - JJ cord-010119-t1x9gknd 123 38 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 123 39 patients patient NNS cord-010119-t1x9gknd 123 40 ( ( -LRB- cord-010119-t1x9gknd 123 41 n55 n55 NNP cord-010119-t1x9gknd 123 42 ) ) -RRB- cord-010119-t1x9gknd 123 43 . . . cord-010119-t1x9gknd 124 1 Patients patient NNS cord-010119-t1x9gknd 124 2 were be VBD cord-010119-t1x9gknd 124 3 matched match VBN cord-010119-t1x9gknd 124 4 for for IN cord-010119-t1x9gknd 124 5 numbers number NNS cord-010119-t1x9gknd 124 6 of of IN cord-010119-t1x9gknd 124 7 RBC RBC NNP cord-010119-t1x9gknd 124 8 transfusions transfusion NNS cord-010119-t1x9gknd 124 9 . . . cord-010119-t1x9gknd 125 1 Results result NNS cord-010119-t1x9gknd 125 2 / / SYM cord-010119-t1x9gknd 125 3 Finding finding NN cord-010119-t1x9gknd 125 4 : : : cord-010119-t1x9gknd 126 1 Mice mouse NNS cord-010119-t1x9gknd 126 2 : : : cord-010119-t1x9gknd 126 3 The the DT cord-010119-t1x9gknd 126 4 MFI MFI NNP cord-010119-t1x9gknd 126 5 of of IN cord-010119-t1x9gknd 126 6 anti anti JJ cord-010119-t1x9gknd 126 7 - - JJ cord-010119-t1x9gknd 126 8 HOD HOD NNP cord-010119-t1x9gknd 126 9 antibodies antibody NNS cord-010119-t1x9gknd 126 10 was be VBD cord-010119-t1x9gknd 126 11 significantly significantly RB cord-010119-t1x9gknd 126 12 increased increase VBN cord-010119-t1x9gknd 126 13 in in IN cord-010119-t1x9gknd 126 14 PMN PMN NNP cord-010119-t1x9gknd 126 15 - - HYPH cord-010119-t1x9gknd 126 16 depleted deplete VBN cord-010119-t1x9gknd 126 17 mice mouse NNS cord-010119-t1x9gknd 126 18 , , , cord-010119-t1x9gknd 126 19 compared compare VBN cord-010119-t1x9gknd 126 20 to to IN cord-010119-t1x9gknd 126 21 controls control NNS cord-010119-t1x9gknd 126 22 ( ( -LRB- cord-010119-t1x9gknd 126 23 3/3 3/3 CD cord-010119-t1x9gknd 126 24 experiments experiment NNS cord-010119-t1x9gknd 126 25 , , , cord-010119-t1x9gknd 126 26 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 126 27 ) ) -RRB- cord-010119-t1x9gknd 126 28 . . . cord-010119-t1x9gknd 127 1 While while IN cord-010119-t1x9gknd 127 2 many many JJ cord-010119-t1x9gknd 127 3 control control NN cord-010119-t1x9gknd 127 4 mice mouse NNS cord-010119-t1x9gknd 127 5 made make VBD cord-010119-t1x9gknd 127 6 no no DT cord-010119-t1x9gknd 127 7 alloantibody alloantibody NN cord-010119-t1x9gknd 127 8 ( ( -LRB- cord-010119-t1x9gknd 127 9 non non NNS cord-010119-t1x9gknd 127 10 - - NNS cord-010119-t1x9gknd 127 11 responders responder NNS cord-010119-t1x9gknd 127 12 ) ) -RRB- cord-010119-t1x9gknd 127 13 , , , cord-010119-t1x9gknd 127 14 all all DT cord-010119-t1x9gknd 127 15 PMN pmn NN cord-010119-t1x9gknd 127 16 - - HYPH cord-010119-t1x9gknd 127 17 depleted deplete VBN cord-010119-t1x9gknd 127 18 mice mouse NNS cord-010119-t1x9gknd 127 19 made make VBD cord-010119-t1x9gknd 127 20 detectable detectable JJ cord-010119-t1x9gknd 127 21 anti anti NNP cord-010119-t1x9gknd 127 22 - - JJ cord-010119-t1x9gknd 127 23 HOD HOD NNP cord-010119-t1x9gknd 127 24 . . . cord-010119-t1x9gknd 128 1 PMN pmn NN cord-010119-t1x9gknd 128 2 depletion depletion NN cord-010119-t1x9gknd 128 3 also also RB cord-010119-t1x9gknd 128 4 led lead VBD cord-010119-t1x9gknd 128 5 to to IN cord-010119-t1x9gknd 128 6 a a DT cord-010119-t1x9gknd 128 7 significant significant JJ cord-010119-t1x9gknd 128 8 reduction reduction NN cord-010119-t1x9gknd 128 9 in in IN cord-010119-t1x9gknd 128 10 DiO1 DiO1 NNS cord-010119-t1x9gknd 128 11 leukocytes leukocyte NNS cord-010119-t1x9gknd 128 12 , , , cord-010119-t1x9gknd 128 13 suggesting suggest VBG cord-010119-t1x9gknd 128 14 a a DT cord-010119-t1x9gknd 128 15 lack lack NN cord-010119-t1x9gknd 128 16 of of IN cord-010119-t1x9gknd 128 17 compensatory compensatory JJ cord-010119-t1x9gknd 128 18 mechanism(s mechanism(s NNP cord-010119-t1x9gknd 128 19 ) ) -RRB- cord-010119-t1x9gknd 128 20 for for IN cord-010119-t1x9gknd 128 21 RBC RBC NNP cord-010119-t1x9gknd 128 22 consumption consumption NN cord-010119-t1x9gknd 128 23 . . . cord-010119-t1x9gknd 129 1 Absence absence NN cord-010119-t1x9gknd 129 2 of of IN cord-010119-t1x9gknd 129 3 PMNs pmn NNS cord-010119-t1x9gknd 129 4 also also RB cord-010119-t1x9gknd 129 5 shifted shift VBD cord-010119-t1x9gknd 129 6 RBC RBC NNP cord-010119-t1x9gknd 129 7 consumption consumption NN cord-010119-t1x9gknd 129 8 from from IN cord-010119-t1x9gknd 129 9 macrophages macrophage NNS cord-010119-t1x9gknd 129 10 to to IN cord-010119-t1x9gknd 129 11 immune immune JJ cord-010119-t1x9gknd 129 12 - - HYPH cord-010119-t1x9gknd 129 13 stimulating stimulate VBG cord-010119-t1x9gknd 129 14 dendritic dendritic JJ cord-010119-t1x9gknd 129 15 cell cell NN cord-010119-t1x9gknd 129 16 subsets subset NNS cord-010119-t1x9gknd 129 17 . . . cord-010119-t1x9gknd 130 1 Flow flow VB cord-010119-t1x9gknd 130 2 cytometric cytometric NN cord-010119-t1x9gknd 130 3 analysis analysis NN cord-010119-t1x9gknd 130 4 revealed reveal VBD cord-010119-t1x9gknd 130 5 that that IN cord-010119-t1x9gknd 130 6 PMNs pmn NNS cord-010119-t1x9gknd 130 7 with with IN cord-010119-t1x9gknd 130 8 internalized internalize VBN cord-010119-t1x9gknd 130 9 RBCs rbc NNS cord-010119-t1x9gknd 130 10 upregulated upregulate VBD cord-010119-t1x9gknd 130 11 expression expression NN cord-010119-t1x9gknd 130 12 of of IN cord-010119-t1x9gknd 130 13 co co JJ cord-010119-t1x9gknd 130 14 - - JJ cord-010119-t1x9gknd 130 15 inhibitory inhibitory JJ cord-010119-t1x9gknd 130 16 molecules molecule NNS cord-010119-t1x9gknd 130 17 ( ( -LRB- cord-010119-t1x9gknd 130 18 e.g. e.g. RB cord-010119-t1x9gknd 130 19 PD PD NNP cord-010119-t1x9gknd 130 20 - - HYPH cord-010119-t1x9gknd 130 21 L1 L1 NNP cord-010119-t1x9gknd 130 22 ) ) -RRB- cord-010119-t1x9gknd 130 23 , , , cord-010119-t1x9gknd 130 24 compared compare VBN cord-010119-t1x9gknd 130 25 to to IN cord-010119-t1x9gknd 130 26 PMNs pmn NNS cord-010119-t1x9gknd 130 27 ( ( -LRB- cord-010119-t1x9gknd 130 28 without without IN cord-010119-t1x9gknd 130 29 internalized internalize VBN cord-010119-t1x9gknd 130 30 RBCs rbc NNS cord-010119-t1x9gknd 130 31 ) ) -RRB- cord-010119-t1x9gknd 130 32 from from IN cord-010119-t1x9gknd 130 33 the the DT cord-010119-t1x9gknd 130 34 same same JJ cord-010119-t1x9gknd 130 35 mouse mouse NN cord-010119-t1x9gknd 130 36 ; ; : cord-010119-t1x9gknd 130 37 thus thus RB cord-010119-t1x9gknd 130 38 , , , cord-010119-t1x9gknd 130 39 PMNs PMNs NNP cord-010119-t1x9gknd 130 40 may may MD cord-010119-t1x9gknd 130 41 regulate regulate VB cord-010119-t1x9gknd 130 42 alloimmunization alloimmunization NN cord-010119-t1x9gknd 130 43 through through IN cord-010119-t1x9gknd 130 44 antigen antigen NN cord-010119-t1x9gknd 130 45 presentation presentation NN cord-010119-t1x9gknd 130 46 and/or and/or CC cord-010119-t1x9gknd 130 47 inhibitory inhibitory JJ cord-010119-t1x9gknd 130 48 signals signal NNS cord-010119-t1x9gknd 130 49 . . . cord-010119-t1x9gknd 131 1 Humans human NNS cord-010119-t1x9gknd 131 2 : : : cord-010119-t1x9gknd 131 3 . . . cord-010119-t1x9gknd 132 1 Alloimmunized Alloimmunized NNP cord-010119-t1x9gknd 132 2 MDS MDS NNP cord-010119-t1x9gknd 132 3 patients patient NNS cord-010119-t1x9gknd 132 4 had have VBD cord-010119-t1x9gknd 132 5 a a DT cord-010119-t1x9gknd 132 6 significant significant JJ cord-010119-t1x9gknd 132 7 decrease decrease NN cord-010119-t1x9gknd 132 8 in in IN cord-010119-t1x9gknd 132 9 PMNs pmn NNS cord-010119-t1x9gknd 132 10 , , , cord-010119-t1x9gknd 132 11 compared compare VBN cord-010119-t1x9gknd 132 12 to to IN cord-010119-t1x9gknd 132 13 non non JJ cord-010119-t1x9gknd 132 14 - - JJ cord-010119-t1x9gknd 132 15 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 132 16 ( ( -LRB- cord-010119-t1x9gknd 132 17 p<0.05 p<0.05 NNP cord-010119-t1x9gknd 132 18 ) ) -RRB- cord-010119-t1x9gknd 132 19 ; ; : cord-010119-t1x9gknd 132 20 no no DT cord-010119-t1x9gknd 132 21 significant significant JJ cord-010119-t1x9gknd 132 22 differences difference NNS cord-010119-t1x9gknd 132 23 were be VBD cord-010119-t1x9gknd 132 24 detected detect VBN cord-010119-t1x9gknd 132 25 in in IN cord-010119-t1x9gknd 132 26 mean mean NN cord-010119-t1x9gknd 133 1 WBC WBC NNP cord-010119-t1x9gknd 133 2 counts count VBZ cord-010119-t1x9gknd 133 3 between between IN cord-010119-t1x9gknd 133 4 the the DT cord-010119-t1x9gknd 133 5 two two CD cord-010119-t1x9gknd 133 6 arms arm NNS cord-010119-t1x9gknd 133 7 . . . cord-010119-t1x9gknd 134 1 Conclusion conclusion NN cord-010119-t1x9gknd 134 2 : : : cord-010119-t1x9gknd 135 1 These these DT cord-010119-t1x9gknd 135 2 data datum NNS cord-010119-t1x9gknd 135 3 demonstrate demonstrate VBP cord-010119-t1x9gknd 135 4 that that IN cord-010119-t1x9gknd 135 5 in in IN cord-010119-t1x9gknd 135 6 both both CC cord-010119-t1x9gknd 135 7 murine murine JJ cord-010119-t1x9gknd 135 8 and and CC cord-010119-t1x9gknd 135 9 human human JJ cord-010119-t1x9gknd 135 10 settings setting NNS cord-010119-t1x9gknd 135 11 , , , cord-010119-t1x9gknd 135 12 PMNs pmn NNS cord-010119-t1x9gknd 135 13 may may MD cord-010119-t1x9gknd 135 14 play play VB cord-010119-t1x9gknd 135 15 a a DT cord-010119-t1x9gknd 135 16 significant significant JJ cord-010119-t1x9gknd 135 17 role role NN cord-010119-t1x9gknd 135 18 in in IN cord-010119-t1x9gknd 135 19 regulating regulate VBG cord-010119-t1x9gknd 135 20 RBC RBC NNP cord-010119-t1x9gknd 135 21 alloimmunization alloimmunization NN cord-010119-t1x9gknd 135 22 and and CC cord-010119-t1x9gknd 135 23 may may MD cord-010119-t1x9gknd 135 24 provide provide VB cord-010119-t1x9gknd 135 25 key key JJ cord-010119-t1x9gknd 135 26 insights insight NNS cord-010119-t1x9gknd 135 27 into into IN cord-010119-t1x9gknd 135 28 predicting predict VBG cord-010119-t1x9gknd 135 29 which which WDT cord-010119-t1x9gknd 135 30 patients patient NNS cord-010119-t1x9gknd 135 31 will will MD cord-010119-t1x9gknd 135 32 become become VB cord-010119-t1x9gknd 135 33 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 135 34 . . . cord-010119-t1x9gknd 136 1 B9-A03B B9-A03B NNP cord-010119-t1x9gknd 136 2 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 136 3 1 1 CD cord-010119-t1x9gknd 136 4 PD1 pd1 NN cord-010119-t1x9gknd 136 5 1 1 CD cord-010119-t1x9gknd 136 6 and and CC cord-010119-t1x9gknd 136 7 CCR7 CCR7 NNP cord-010119-t1x9gknd 136 8 1 1 CD cord-010119-t1x9gknd 136 9 Expressions expression NNS cord-010119-t1x9gknd 136 10 Characterize characterize VBP cord-010119-t1x9gknd 136 11 Responders Responders NNPS cord-010119-t1x9gknd 136 12 to to IN cord-010119-t1x9gknd 136 13 RBC RBC NNP cord-010119-t1x9gknd 136 14 Immunization Immunization NNP cord-010119-t1x9gknd 136 15 Benoît Benoît NNP cord-010119-t1x9gknd 136 16 Vingert Vingert NNP cord-010119-t1x9gknd 136 17 * * NFP cord-010119-t1x9gknd 136 18 1,2,3 1,2,3 CD cord-010119-t1x9gknd 136 19 , , , cord-010119-t1x9gknd 136 20 Marie Marie NNP cord-010119-t1x9gknd 136 21 Tamagne Tamagne NNP cord-010119-t1x9gknd 136 22 1,2,3 1,2,3 CD cord-010119-t1x9gknd 136 23 , , , cord-010119-t1x9gknd 136 24 Sadaf Sadaf NNP cord-010119-t1x9gknd 136 25 Pakdaman Pakdaman NNP cord-010119-t1x9gknd 136 26 1,2,3 1,2,3 CD cord-010119-t1x9gknd 136 27 , , , cord-010119-t1x9gknd 136 28 Anoosha Anoosha NNP cord-010119-t1x9gknd 136 29 Habibi Habibi NNP cord-010119-t1x9gknd 136 30 2,3,4 2,3,4 CD cord-010119-t1x9gknd 136 31 , , , cord-010119-t1x9gknd 136 32 Philippe Philippe NNP cord-010119-t1x9gknd 136 33 Bierling Bierling NNP cord-010119-t1x9gknd 137 1 1,2,3,4,5 1,2,3,4,5 LS cord-010119-t1x9gknd 137 2 , , , cord-010119-t1x9gknd 137 3 Rachid Rachid NNP cord-010119-t1x9gknd 137 4 Djoudi Djoudi NNP cord-010119-t1x9gknd 137 5 1 1 CD cord-010119-t1x9gknd 137 6 and and CC cord-010119-t1x9gknd 137 7 France France NNP cord-010119-t1x9gknd 137 8 Pirenne Pirenne NNP cord-010119-t1x9gknd 138 1 1,2,3,5 1,2,3,5 NNP cord-010119-t1x9gknd 138 2 . . . cord-010119-t1x9gknd 139 1 1 1 CD cord-010119-t1x9gknd 139 2 EFS EFS NNP cord-010119-t1x9gknd 139 3 Ile Ile NNP cord-010119-t1x9gknd 139 4 de de NNP cord-010119-t1x9gknd 139 5 France France NNP cord-010119-t1x9gknd 139 6 , , , cord-010119-t1x9gknd 139 7 2 2 CD cord-010119-t1x9gknd 139 8 Laboratory Laboratory NNP cord-010119-t1x9gknd 139 9 of of IN cord-010119-t1x9gknd 139 10 Excellence Excellence NNP cord-010119-t1x9gknd 139 11 GR GR NNP cord-010119-t1x9gknd 139 12 - - HYPH cord-010119-t1x9gknd 139 13 Ex Ex NNP cord-010119-t1x9gknd 139 14 , , , cord-010119-t1x9gknd 139 15 3 3 CD cord-010119-t1x9gknd 139 16 IMRB IMRB NNP cord-010119-t1x9gknd 139 17 U955 U955 NNP cord-010119-t1x9gknd 139 18 -Eq2 -eq2 NN cord-010119-t1x9gknd 139 19 , , , cord-010119-t1x9gknd 139 20 4 4 CD cord-010119-t1x9gknd 139 21 AP AP NNP cord-010119-t1x9gknd 139 22 - - HYPH cord-010119-t1x9gknd 139 23 HP HP NNP cord-010119-t1x9gknd 139 24 , , , cord-010119-t1x9gknd 139 25 5 5 CD cord-010119-t1x9gknd 139 26 Universit Universit NNP cord-010119-t1x9gknd 139 27 e e . cord-010119-t1x9gknd 139 28 Paris Paris NNP cord-010119-t1x9gknd 139 29 Est Est NNP cord-010119-t1x9gknd 139 30 Background Background NNP cord-010119-t1x9gknd 139 31 / / SYM cord-010119-t1x9gknd 139 32 Case Case NNP cord-010119-t1x9gknd 139 33 Studies Studies NNPS cord-010119-t1x9gknd 140 1 : : : cord-010119-t1x9gknd 140 2 Post post JJ cord-010119-t1x9gknd 140 3 - - JJ cord-010119-t1x9gknd 140 4 transfusion transfusion NN cord-010119-t1x9gknd 140 5 alloimmunization alloimmunization NN cord-010119-t1x9gknd 140 6 can can MD cord-010119-t1x9gknd 140 7 induce induce VB cord-010119-t1x9gknd 140 8 life life NN cord-010119-t1x9gknd 140 9 - - HYPH cord-010119-t1x9gknd 140 10 threatening threaten VBG cord-010119-t1x9gknd 140 11 hemolytic hemolytic JJ cord-010119-t1x9gknd 140 12 transfusion transfusion NN cord-010119-t1x9gknd 140 13 reaction reaction NN cord-010119-t1x9gknd 140 14 . . . cord-010119-t1x9gknd 141 1 In in IN cord-010119-t1x9gknd 141 2 human human NN cord-010119-t1x9gknd 141 3 , , , cord-010119-t1x9gknd 141 4 mechanisms mechanism NNS cord-010119-t1x9gknd 141 5 responsible responsible JJ cord-010119-t1x9gknd 141 6 of of IN cord-010119-t1x9gknd 141 7 RBC RBC NNP cord-010119-t1x9gknd 141 8 alloimmunization alloimmunization NN cord-010119-t1x9gknd 141 9 are be VBP cord-010119-t1x9gknd 141 10 not not RB cord-010119-t1x9gknd 141 11 fully fully RB cord-010119-t1x9gknd 141 12 defined define VBN cord-010119-t1x9gknd 141 13 . . . cord-010119-t1x9gknd 142 1 CD4 CD4 NNP cord-010119-t1x9gknd 142 2 1 1 CD cord-010119-t1x9gknd 142 3 T T NNP cord-010119-t1x9gknd 142 4 cells cell NNS cord-010119-t1x9gknd 142 5 are be VBP cord-010119-t1x9gknd 142 6 major major JJ cord-010119-t1x9gknd 142 7 for for IN cord-010119-t1x9gknd 142 8 antibodies antibody NNS cord-010119-t1x9gknd 142 9 production production NN cord-010119-t1x9gknd 142 10 . . . cord-010119-t1x9gknd 143 1 We -PRON- PRP cord-010119-t1x9gknd 143 2 have have VBP cord-010119-t1x9gknd 143 3 already already RB cord-010119-t1x9gknd 143 4 shown show VBN cord-010119-t1x9gknd 143 5 in in IN cord-010119-t1x9gknd 143 6 responder responder NN cord-010119-t1x9gknd 143 7 patients patient NNS cord-010119-t1x9gknd 143 8 that that IN cord-010119-t1x9gknd 143 9 the the DT cord-010119-t1x9gknd 143 10 majority majority NN cord-010119-t1x9gknd 143 11 of of IN cord-010119-t1x9gknd 143 12 anti anti JJ cord-010119-t1x9gknd 143 13 - - JJ cord-010119-t1x9gknd 143 14 RBC RBC NNP cord-010119-t1x9gknd 143 15 CD4 CD4 NNP cord-010119-t1x9gknd 143 16 1 1 CD cord-010119-t1x9gknd 143 17 T T NNP cord-010119-t1x9gknd 143 18 cells cell NNS cord-010119-t1x9gknd 143 19 have have VBP cord-010119-t1x9gknd 143 20 a a DT cord-010119-t1x9gknd 143 21 Th17 th17 NN cord-010119-t1x9gknd 143 22 profile profile NN cord-010119-t1x9gknd 143 23 . . . cord-010119-t1x9gknd 144 1 In in IN cord-010119-t1x9gknd 144 2 contrast contrast NN cord-010119-t1x9gknd 144 3 , , , cord-010119-t1x9gknd 144 4 in in IN cord-010119-t1x9gknd 144 5 whole whole JJ cord-010119-t1x9gknd 144 6 blood blood NN cord-010119-t1x9gknd 144 7 of of IN cord-010119-t1x9gknd 144 8 non non JJ cord-010119-t1x9gknd 144 9 - - JJ cord-010119-t1x9gknd 144 10 responder responder JJ cord-010119-t1x9gknd 144 11 patients patient NNS cord-010119-t1x9gknd 144 12 , , , cord-010119-t1x9gknd 144 13 there there EX cord-010119-t1x9gknd 144 14 is be VBZ cord-010119-t1x9gknd 144 15 an an DT cord-010119-t1x9gknd 144 16 unexpected unexpected JJ cord-010119-t1x9gknd 144 17 expression expression NN cord-010119-t1x9gknd 144 18 of of IN cord-010119-t1x9gknd 144 19 circulating circulate VBG cord-010119-t1x9gknd 144 20 CD4 CD4 NNP cord-010119-t1x9gknd 144 21 1 1 CD cord-010119-t1x9gknd 144 22 T T NNP cord-010119-t1x9gknd 144 23 cells cell NNS cord-010119-t1x9gknd 144 24 with with IN cord-010119-t1x9gknd 144 25 a a DT cord-010119-t1x9gknd 144 26 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 144 27 1 1 CD cord-010119-t1x9gknd 144 28 PD1 pd1 NN cord-010119-t1x9gknd 144 29 1 1 CD cord-010119-t1x9gknd 144 30 phenotype phenotype NN cord-010119-t1x9gknd 144 31 . . . cord-010119-t1x9gknd 145 1 This this DT cord-010119-t1x9gknd 145 2 phenotype phenotype NN cord-010119-t1x9gknd 145 3 is be VBZ cord-010119-t1x9gknd 145 4 usually usually RB cord-010119-t1x9gknd 145 5 associated associate VBN cord-010119-t1x9gknd 145 6 with with IN cord-010119-t1x9gknd 145 7 the the DT cord-010119-t1x9gknd 145 8 presence presence NN cord-010119-t1x9gknd 145 9 of of IN cord-010119-t1x9gknd 145 10 Tfh Tfh NNP cord-010119-t1x9gknd 145 11 cells cell NNS cord-010119-t1x9gknd 145 12 , , , cord-010119-t1x9gknd 145 13 specialized specialize VBN cord-010119-t1x9gknd 145 14 in in IN cord-010119-t1x9gknd 145 15 the the DT cord-010119-t1x9gknd 145 16 production production NN cord-010119-t1x9gknd 145 17 of of IN cord-010119-t1x9gknd 145 18 antibodies antibody NNS cord-010119-t1x9gknd 145 19 . . . cord-010119-t1x9gknd 146 1 It -PRON- PRP cord-010119-t1x9gknd 146 2 has have VBZ cord-010119-t1x9gknd 146 3 been be VBN cord-010119-t1x9gknd 146 4 suggested suggest VBN cord-010119-t1x9gknd 146 5 that that IN cord-010119-t1x9gknd 146 6 some some DT cord-010119-t1x9gknd 146 7 of of IN cord-010119-t1x9gknd 146 8 the the DT cord-010119-t1x9gknd 146 9 activated activate VBN cord-010119-t1x9gknd 146 10 circulating circulate VBG cord-010119-t1x9gknd 146 11 Tfh Tfh NNP cord-010119-t1x9gknd 146 12 could could MD cord-010119-t1x9gknd 146 13 have have VB cord-010119-t1x9gknd 146 14 a a DT cord-010119-t1x9gknd 146 15 CXCR5 cxcr5 NN cord-010119-t1x9gknd 146 16 1 1 CD cord-010119-t1x9gknd 146 17 PD1 pd1 NN cord-010119-t1x9gknd 146 18 hi hi UH cord-010119-t1x9gknd 146 19 profile profile NN cord-010119-t1x9gknd 146 20 , , , cord-010119-t1x9gknd 146 21 with with IN cord-010119-t1x9gknd 146 22 a a DT cord-010119-t1x9gknd 146 23 differentiated differentiated JJ cord-010119-t1x9gknd 146 24 expression expression NN cord-010119-t1x9gknd 146 25 of of IN cord-010119-t1x9gknd 146 26 CCR7 CCR7 NNP cord-010119-t1x9gknd 146 27 . . . cord-010119-t1x9gknd 147 1 CCR7 CCR7 NNP cord-010119-t1x9gknd 147 2 is be VBZ cord-010119-t1x9gknd 147 3 essential essential JJ cord-010119-t1x9gknd 147 4 for for IN cord-010119-t1x9gknd 147 5 T T NNP cord-010119-t1x9gknd 147 6 cells cell NNS cord-010119-t1x9gknd 147 7 domiciliation domiciliation NN cord-010119-t1x9gknd 147 8 in in IN cord-010119-t1x9gknd 147 9 lymph lymph NN cord-010119-t1x9gknd 147 10 nodes node NNS cord-010119-t1x9gknd 147 11 where where WRB cord-010119-t1x9gknd 147 12 the the DT cord-010119-t1x9gknd 147 13 encounter encounter NN cord-010119-t1x9gknd 147 14 T t NN cord-010119-t1x9gknd 147 15 and and CC cord-010119-t1x9gknd 147 16 B B NNP cord-010119-t1x9gknd 147 17 cells cell NNS cord-010119-t1x9gknd 147 18 is be VBZ cord-010119-t1x9gknd 147 19 major major JJ cord-010119-t1x9gknd 147 20 for for IN cord-010119-t1x9gknd 147 21 B b NN cord-010119-t1x9gknd 147 22 cell cell NN cord-010119-t1x9gknd 147 23 differentiation differentiation NN cord-010119-t1x9gknd 147 24 and and CC cord-010119-t1x9gknd 147 25 antibody antibody NN cord-010119-t1x9gknd 147 26 production production NN cord-010119-t1x9gknd 147 27 . . . cord-010119-t1x9gknd 148 1 Others other NNS cord-010119-t1x9gknd 148 2 chemokines chemokine NNS cord-010119-t1x9gknd 148 3 receptor receptor NN cord-010119-t1x9gknd 148 4 like like IN cord-010119-t1x9gknd 148 5 CCR6 CCR6 NNP cord-010119-t1x9gknd 148 6 and and CC cord-010119-t1x9gknd 148 7 CXCR3 cxcr3 NN cord-010119-t1x9gknd 148 8 can can MD cord-010119-t1x9gknd 148 9 also also RB cord-010119-t1x9gknd 148 10 differentiate differentiate VB cord-010119-t1x9gknd 148 11 circulating circulate VBG cord-010119-t1x9gknd 148 12 Tfh Tfh NNP cord-010119-t1x9gknd 148 13 subpopulations subpopulation NNS cord-010119-t1x9gknd 148 14 . . . cord-010119-t1x9gknd 149 1 In in IN cord-010119-t1x9gknd 149 2 this this DT cord-010119-t1x9gknd 149 3 study study NN cord-010119-t1x9gknd 149 4 , , , cord-010119-t1x9gknd 149 5 we -PRON- PRP cord-010119-t1x9gknd 149 6 were be VBD cord-010119-t1x9gknd 149 7 interested interested JJ cord-010119-t1x9gknd 149 8 in in IN cord-010119-t1x9gknd 149 9 the the DT cord-010119-t1x9gknd 149 10 phenotype phenotype NN cord-010119-t1x9gknd 149 11 and and CC cord-010119-t1x9gknd 149 12 function function NN cord-010119-t1x9gknd 149 13 of of IN cord-010119-t1x9gknd 149 14 these these DT cord-010119-t1x9gknd 149 15 CXCR5 cxcr5 JJ cord-010119-t1x9gknd 149 16 1 1 CD cord-010119-t1x9gknd 149 17 PD1 pd1 NN cord-010119-t1x9gknd 149 18 1 1 CD cord-010119-t1x9gknd 149 19 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 149 20 which which WDT cord-010119-t1x9gknd 149 21 were be VBD cord-010119-t1x9gknd 149 22 paradoxically paradoxically RB cord-010119-t1x9gknd 149 23 highly highly RB cord-010119-t1x9gknd 149 24 represented represent VBN cord-010119-t1x9gknd 149 25 in in IN cord-010119-t1x9gknd 149 26 non non JJ cord-010119-t1x9gknd 149 27 - - JJ cord-010119-t1x9gknd 149 28 responder responder JJ cord-010119-t1x9gknd 149 29 patients patient NNS cord-010119-t1x9gknd 149 30 . . . cord-010119-t1x9gknd 150 1 Study Study NNP cord-010119-t1x9gknd 150 2 Design Design NNP cord-010119-t1x9gknd 150 3 / / SYM cord-010119-t1x9gknd 150 4 Method method NN cord-010119-t1x9gknd 150 5 : : : cord-010119-t1x9gknd 151 1 The the DT cord-010119-t1x9gknd 151 2 membrane membrane NN cord-010119-t1x9gknd 151 3 and and CC cord-010119-t1x9gknd 151 4 functional functional JJ cord-010119-t1x9gknd 151 5 phenotype phenotype NN cord-010119-t1x9gknd 151 6 of of IN cord-010119-t1x9gknd 151 7 the the DT cord-010119-t1x9gknd 151 8 circulating circulate VBG cord-010119-t1x9gknd 151 9 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 151 10 1 1 CD cord-010119-t1x9gknd 151 11 PD1 pd1 NN cord-010119-t1x9gknd 151 12 1 1 CD cord-010119-t1x9gknd 151 13 cells cell NNS cord-010119-t1x9gknd 151 14 were be VBD cord-010119-t1x9gknd 151 15 compared compare VBN cord-010119-t1x9gknd 151 16 in in IN cord-010119-t1x9gknd 151 17 2 2 CD cord-010119-t1x9gknd 151 18 groups group NNS cord-010119-t1x9gknd 151 19 of of IN cord-010119-t1x9gknd 151 20 transfused transfused JJ cord-010119-t1x9gknd 151 21 sickle sickle NN cord-010119-t1x9gknd 151 22 cell cell NN cord-010119-t1x9gknd 151 23 patients patient NNS cord-010119-t1x9gknd 151 24 : : : cord-010119-t1x9gknd 152 1 alloimmunized alloimmunized NNP cord-010119-t1x9gknd 152 2 ( ( -LRB- cord-010119-t1x9gknd 152 3 n514 n514 NNP cord-010119-t1x9gknd 152 4 ) ) -RRB- cord-010119-t1x9gknd 152 5 and and CC cord-010119-t1x9gknd 152 6 non non JJ cord-010119-t1x9gknd 152 7 - - JJ cord-010119-t1x9gknd 152 8 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 152 9 patients patient NNS cord-010119-t1x9gknd 152 10 ( ( -LRB- cord-010119-t1x9gknd 152 11 n510 n510 NNP cord-010119-t1x9gknd 152 12 ) ) -RRB- cord-010119-t1x9gknd 152 13 . . . cord-010119-t1x9gknd 153 1 The the DT cord-010119-t1x9gknd 153 2 analysis analysis NN cord-010119-t1x9gknd 153 3 was be VBD cord-010119-t1x9gknd 153 4 also also RB cord-010119-t1x9gknd 153 5 performed perform VBN cord-010119-t1x9gknd 153 6 in in IN cord-010119-t1x9gknd 153 7 non non JJ cord-010119-t1x9gknd 153 8 - - JJ cord-010119-t1x9gknd 153 9 transfused transfused JJ cord-010119-t1x9gknd 153 10 healthy healthy JJ cord-010119-t1x9gknd 153 11 controls control NNS cord-010119-t1x9gknd 153 12 ( ( -LRB- cord-010119-t1x9gknd 153 13 n512 n512 NNP cord-010119-t1x9gknd 153 14 ) ) -RRB- cord-010119-t1x9gknd 153 15 . . . cord-010119-t1x9gknd 154 1 All all DT cord-010119-t1x9gknd 154 2 assays assay NNS cord-010119-t1x9gknd 154 3 were be VBD cord-010119-t1x9gknd 154 4 performed perform VBN cord-010119-t1x9gknd 154 5 on on IN cord-010119-t1x9gknd 154 6 whole whole JJ cord-010119-t1x9gknd 154 7 blood blood NN cord-010119-t1x9gknd 154 8 without without IN cord-010119-t1x9gknd 154 9 separation separation NN cord-010119-t1x9gknd 154 10 procedures procedure NNS cord-010119-t1x9gknd 154 11 that that WDT cord-010119-t1x9gknd 154 12 are be VBP cord-010119-t1x9gknd 154 13 known know VBN cord-010119-t1x9gknd 154 14 to to TO cord-010119-t1x9gknd 154 15 alter alter VB cord-010119-t1x9gknd 154 16 the the DT cord-010119-t1x9gknd 154 17 expression expression NN cord-010119-t1x9gknd 154 18 of of IN cord-010119-t1x9gknd 154 19 chemokine chemokine NN cord-010119-t1x9gknd 154 20 receptors receptor NNS cord-010119-t1x9gknd 154 21 Results/ Results/ . cord-010119-t1x9gknd 155 1 Finding finding NN cord-010119-t1x9gknd 155 2 : : : cord-010119-t1x9gknd 156 1 The the DT cord-010119-t1x9gknd 156 2 CXCR5 cxcr5 NN cord-010119-t1x9gknd 156 3 1 1 CD cord-010119-t1x9gknd 156 4 PD1 pd1 NN cord-010119-t1x9gknd 156 5 hi hi CD cord-010119-t1x9gknd 156 6 subpopulation subpopulation NN cord-010119-t1x9gknd 156 7 expression expression NN cord-010119-t1x9gknd 156 8 was be VBD cord-010119-t1x9gknd 156 9 identical identical JJ cord-010119-t1x9gknd 156 10 between between IN cord-010119-t1x9gknd 156 11 transfused transfused JJ cord-010119-t1x9gknd 156 12 groups group NNS cord-010119-t1x9gknd 156 13 and and CC cord-010119-t1x9gknd 156 14 controls control NNS cord-010119-t1x9gknd 156 15 . . . cord-010119-t1x9gknd 157 1 CCR6 CCR6 NNP cord-010119-t1x9gknd 157 2 and and CC cord-010119-t1x9gknd 157 3 CXCR3 cxcr3 IN cord-010119-t1x9gknd 157 4 expressions expression NNS cord-010119-t1x9gknd 157 5 show show VBP cord-010119-t1x9gknd 157 6 no no DT cord-010119-t1x9gknd 157 7 difference difference NN cord-010119-t1x9gknd 157 8 between between IN cord-010119-t1x9gknd 157 9 the the DT cord-010119-t1x9gknd 157 10 transfused transfuse VBN cord-010119-t1x9gknd 157 11 groups group NNS cord-010119-t1x9gknd 157 12 or or CC cord-010119-t1x9gknd 157 13 the the DT cord-010119-t1x9gknd 157 14 controls control NNS cord-010119-t1x9gknd 157 15 . . . cord-010119-t1x9gknd 158 1 However however RB cord-010119-t1x9gknd 158 2 , , , cord-010119-t1x9gknd 158 3 in in IN cord-010119-t1x9gknd 158 4 non non JJ cord-010119-t1x9gknd 158 5 - - JJ cord-010119-t1x9gknd 158 6 responder responder JJ cord-010119-t1x9gknd 158 7 patients patient NNS cord-010119-t1x9gknd 158 8 , , , cord-010119-t1x9gknd 158 9 CCR7 CCR7 NNP cord-010119-t1x9gknd 158 10 expression expression NN cord-010119-t1x9gknd 158 11 was be VBD cord-010119-t1x9gknd 158 12 very very RB cord-010119-t1x9gknd 158 13 strong strong JJ cord-010119-t1x9gknd 158 14 independently independently RB cord-010119-t1x9gknd 158 15 of of IN cord-010119-t1x9gknd 158 16 the the DT cord-010119-t1x9gknd 158 17 expression expression NN cord-010119-t1x9gknd 158 18 of of IN cord-010119-t1x9gknd 158 19 PD1 PD1 NNP cord-010119-t1x9gknd 158 20 . . . cord-010119-t1x9gknd 159 1 In in IN cord-010119-t1x9gknd 159 2 the the DT cord-010119-t1x9gknd 159 3 aim aim NN cord-010119-t1x9gknd 159 4 to to TO cord-010119-t1x9gknd 159 5 determine determine VB cord-010119-t1x9gknd 159 6 the the DT cord-010119-t1x9gknd 159 7 help help NN cord-010119-t1x9gknd 159 8 of of IN cord-010119-t1x9gknd 159 9 the the DT cord-010119-t1x9gknd 159 10 circulating circulate VBG cord-010119-t1x9gknd 159 11 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 159 12 1 1 CD cord-010119-t1x9gknd 159 13 PD1 pd1 NN cord-010119-t1x9gknd 159 14 1 1 CD cord-010119-t1x9gknd 159 15 cells cell NNS cord-010119-t1x9gknd 159 16 in in IN cord-010119-t1x9gknd 159 17 the the DT cord-010119-t1x9gknd 159 18 production production NN cord-010119-t1x9gknd 159 19 of of IN cord-010119-t1x9gknd 159 20 antibodies antibody NNS cord-010119-t1x9gknd 159 21 , , , cord-010119-t1x9gknd 159 22 these these DT cord-010119-t1x9gknd 159 23 cells cell NNS cord-010119-t1x9gknd 159 24 were be VBD cord-010119-t1x9gknd 159 25 purified purify VBN cord-010119-t1x9gknd 159 26 by by IN cord-010119-t1x9gknd 159 27 flow flow NN cord-010119-t1x9gknd 159 28 cytometry cytometry NN cord-010119-t1x9gknd 159 29 and and CC cord-010119-t1x9gknd 159 30 co co JJ cord-010119-t1x9gknd 159 31 - - JJ cord-010119-t1x9gknd 159 32 cultured cultured JJ cord-010119-t1x9gknd 159 33 for for IN cord-010119-t1x9gknd 159 34 5 5 CD cord-010119-t1x9gknd 159 35 days day NNS cord-010119-t1x9gknd 159 36 with with IN cord-010119-t1x9gknd 159 37 B b NN cord-010119-t1x9gknd 159 38 cells cell NNS cord-010119-t1x9gknd 159 39 , , , cord-010119-t1x9gknd 159 40 and and CC cord-010119-t1x9gknd 159 41 in in IN cord-010119-t1x9gknd 159 42 the the DT cord-010119-t1x9gknd 159 43 presence presence NN cord-010119-t1x9gknd 159 44 of of IN cord-010119-t1x9gknd 159 45 SEB SEB NNP cord-010119-t1x9gknd 159 46 protein protein NN cord-010119-t1x9gknd 159 47 . . . cord-010119-t1x9gknd 160 1 The the DT cord-010119-t1x9gknd 160 2 levels level NNS cord-010119-t1x9gknd 160 3 of of IN cord-010119-t1x9gknd 160 4 antibodies antibody NNS cord-010119-t1x9gknd 160 5 after after IN cord-010119-t1x9gknd 160 6 SEB SEB NNP cord-010119-t1x9gknd 160 7 stimulation stimulation NN cord-010119-t1x9gknd 160 8 were be VBD cord-010119-t1x9gknd 160 9 identical identical JJ cord-010119-t1x9gknd 160 10 with with IN cord-010119-t1x9gknd 160 11 the the DT cord-010119-t1x9gknd 160 12 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 160 13 1 1 CD cord-010119-t1x9gknd 160 14 PD1 pd1 NN cord-010119-t1x9gknd 160 15 1 1 CD cord-010119-t1x9gknd 160 16 subpopulations subpopulation NNS cord-010119-t1x9gknd 160 17 from from IN cord-010119-t1x9gknd 160 18 transfused transfused JJ cord-010119-t1x9gknd 160 19 groups group NNS cord-010119-t1x9gknd 160 20 or or CC cord-010119-t1x9gknd 160 21 controls control NNS cord-010119-t1x9gknd 160 22 . . . cord-010119-t1x9gknd 161 1 Conclusion conclusion NN cord-010119-t1x9gknd 161 2 : : : cord-010119-t1x9gknd 162 1 The the DT cord-010119-t1x9gknd 162 2 paradoxical paradoxical JJ cord-010119-t1x9gknd 162 3 presence presence NN cord-010119-t1x9gknd 162 4 of of IN cord-010119-t1x9gknd 162 5 circulating circulate VBG cord-010119-t1x9gknd 162 6 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 162 7 1 1 CD cord-010119-t1x9gknd 162 8 PD1 pd1 NN cord-010119-t1x9gknd 162 9 1 1 CD cord-010119-t1x9gknd 162 10 cells cell NNS cord-010119-t1x9gknd 162 11 in in IN cord-010119-t1x9gknd 162 12 non non JJ cord-010119-t1x9gknd 162 13 - - JJ cord-010119-t1x9gknd 162 14 responder responder JJ cord-010119-t1x9gknd 162 15 transfused transfuse VBN cord-010119-t1x9gknd 162 16 patients patient NNS cord-010119-t1x9gknd 162 17 do do VBP cord-010119-t1x9gknd 162 18 not not RB cord-010119-t1x9gknd 162 19 appear appear VB cord-010119-t1x9gknd 162 20 to to TO cord-010119-t1x9gknd 162 21 have have VB cord-010119-t1x9gknd 162 22 any any DT cord-010119-t1x9gknd 162 23 particular particular JJ cord-010119-t1x9gknd 162 24 functions function NNS cord-010119-t1x9gknd 162 25 that that WDT cord-010119-t1x9gknd 162 26 can can MD cord-010119-t1x9gknd 162 27 promote promote VB cord-010119-t1x9gknd 162 28 the the DT cord-010119-t1x9gknd 162 29 absence absence NN cord-010119-t1x9gknd 162 30 of of IN cord-010119-t1x9gknd 162 31 a a DT cord-010119-t1x9gknd 162 32 humoral humoral JJ cord-010119-t1x9gknd 162 33 response response NN cord-010119-t1x9gknd 162 34 . . . cord-010119-t1x9gknd 163 1 However however RB cord-010119-t1x9gknd 163 2 , , , cord-010119-t1x9gknd 163 3 in in IN cord-010119-t1x9gknd 163 4 responder responder NN cord-010119-t1x9gknd 163 5 patients patient NNS cord-010119-t1x9gknd 163 6 , , , cord-010119-t1x9gknd 163 7 the the DT cord-010119-t1x9gknd 163 8 high high JJ cord-010119-t1x9gknd 163 9 expression expression NN cord-010119-t1x9gknd 163 10 of of IN cord-010119-t1x9gknd 163 11 CCR7 CCR7 NNP cord-010119-t1x9gknd 163 12 on on IN cord-010119-t1x9gknd 163 13 circulating circulate VBG cord-010119-t1x9gknd 163 14 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 163 15 1 1 CD cord-010119-t1x9gknd 163 16 PD1 pd1 NN cord-010119-t1x9gknd 163 17 1 1 CD cord-010119-t1x9gknd 163 18 cells cell NNS cord-010119-t1x9gknd 163 19 suggests suggest VBZ cord-010119-t1x9gknd 163 20 remarkable remarkable JJ cord-010119-t1x9gknd 163 21 migratory migratory JJ cord-010119-t1x9gknd 163 22 properties property NNS cord-010119-t1x9gknd 163 23 towards towards IN cord-010119-t1x9gknd 163 24 secondary secondary JJ cord-010119-t1x9gknd 163 25 lymphoid lymphoid JJ cord-010119-t1x9gknd 163 26 organs organ NNS cord-010119-t1x9gknd 163 27 , , , cord-010119-t1x9gknd 163 28 and and CC cord-010119-t1x9gknd 163 29 could could MD cord-010119-t1x9gknd 163 30 facilitate facilitate VB cord-010119-t1x9gknd 163 31 allo allo NN cord-010119-t1x9gknd 163 32 - - HYPH cord-010119-t1x9gknd 163 33 immune immune JJ cord-010119-t1x9gknd 163 34 responses response NNS cord-010119-t1x9gknd 163 35 . . . cord-010119-t1x9gknd 164 1 In in IN cord-010119-t1x9gknd 164 2 conclusion conclusion NN cord-010119-t1x9gknd 164 3 , , , cord-010119-t1x9gknd 164 4 the the DT cord-010119-t1x9gknd 164 5 study study NN cord-010119-t1x9gknd 164 6 of of IN cord-010119-t1x9gknd 164 7 the the DT cord-010119-t1x9gknd 164 8 CXCR5 CXCR5 NNP cord-010119-t1x9gknd 164 9 1 1 CD cord-010119-t1x9gknd 164 10 PD1 pd1 NN cord-010119-t1x9gknd 164 11 1 1 CD cord-010119-t1x9gknd 164 12 profile profile NN cord-010119-t1x9gknd 164 13 and and CC cord-010119-t1x9gknd 164 14 the the DT cord-010119-t1x9gknd 164 15 CCR7 CCR7 NNP cord-010119-t1x9gknd 164 16 1 1 CD cord-010119-t1x9gknd 164 17 expression expression NN cord-010119-t1x9gknd 164 18 in in IN cord-010119-t1x9gknd 164 19 these these DT cord-010119-t1x9gknd 164 20 cells cell NNS cord-010119-t1x9gknd 164 21 could could MD cord-010119-t1x9gknd 164 22 help help VB cord-010119-t1x9gknd 164 23 to to TO cord-010119-t1x9gknd 164 24 differentiate differentiate VB cord-010119-t1x9gknd 164 25 responder responder NN cord-010119-t1x9gknd 164 26 and and CC cord-010119-t1x9gknd 164 27 non non JJ cord-010119-t1x9gknd 164 28 - - JJ cord-010119-t1x9gknd 164 29 responder responder JJ cord-010119-t1x9gknd 164 30 patients patient NNS cord-010119-t1x9gknd 164 31 to to IN cord-010119-t1x9gknd 164 32 RBC RBC NNP cord-010119-t1x9gknd 164 33 immunization immunization NN cord-010119-t1x9gknd 164 34 . . . cord-010119-t1x9gknd 165 1 Primed primed JJ cord-010119-t1x9gknd 165 2 CD4 CD4 NNP cord-010119-t1x9gknd 165 3 T T NNP cord-010119-t1x9gknd 165 4 Cells cell NNS cord-010119-t1x9gknd 165 5 to to IN cord-010119-t1x9gknd 165 6 One one CD cord-010119-t1x9gknd 165 7 RBC RBC NNP cord-010119-t1x9gknd 165 8 Alloantigen Alloantigen NNP cord-010119-t1x9gknd 166 1 Can Can MD cord-010119-t1x9gknd 166 2 Enhance enhance VB cord-010119-t1x9gknd 166 3 Subsequent subsequent JJ cord-010119-t1x9gknd 166 4 Alloimmunization Alloimmunization NNP cord-010119-t1x9gknd 166 5 Seema Seema NNP cord-010119-t1x9gknd 166 6 R R NNP cord-010119-t1x9gknd 166 7 Patel Patel NNP cord-010119-t1x9gknd 166 8 * * NFP cord-010119-t1x9gknd 166 9 1 1 CD cord-010119-t1x9gknd 166 10 , , , cord-010119-t1x9gknd 166 11 Ashley Ashley NNP cord-010119-t1x9gknd 166 12 Bennett Bennett NNP cord-010119-t1x9gknd 166 13 1 1 CD cord-010119-t1x9gknd 166 14 , , , cord-010119-t1x9gknd 166 15 Kathryn Kathryn NNP cord-010119-t1x9gknd 166 16 Girard Girard NNP cord-010119-t1x9gknd 166 17 - - HYPH cord-010119-t1x9gknd 166 18 Pierce Pierce NNP cord-010119-t1x9gknd 166 19 1 1 CD cord-010119-t1x9gknd 166 20 , , , cord-010119-t1x9gknd 166 21 Connie Connie NNP cord-010119-t1x9gknd 166 22 Arthur Arthur NNP cord-010119-t1x9gknd 166 23 1 1 CD cord-010119-t1x9gknd 166 24 , , , cord-010119-t1x9gknd 166 25 Amanda Amanda NNP cord-010119-t1x9gknd 166 26 Mener Mener NNP cord-010119-t1x9gknd 166 27 1 1 CD cord-010119-t1x9gknd 166 28 , , , cord-010119-t1x9gknd 166 29 Patty Patty NNP cord-010119-t1x9gknd 166 30 Zerra Zerra NNP cord-010119-t1x9gknd 166 31 1 1 CD cord-010119-t1x9gknd 166 32 , , , cord-010119-t1x9gknd 166 33 Christopher Christopher NNP cord-010119-t1x9gknd 166 34 A A NNP cord-010119-t1x9gknd 166 35 Tormey Tormey NNP cord-010119-t1x9gknd 166 36 2 2 CD cord-010119-t1x9gknd 166 37 , , , cord-010119-t1x9gknd 166 38 Jeanne Jeanne NNP cord-010119-t1x9gknd 166 39 Hendrickson Hendrickson NNP cord-010119-t1x9gknd 166 40 3 3 CD cord-010119-t1x9gknd 166 41 and and CC cord-010119-t1x9gknd 166 42 Sean Sean NNP cord-010119-t1x9gknd 166 43 Stowell Stowell NNP cord-010119-t1x9gknd 166 44 4 4 CD cord-010119-t1x9gknd 166 45 . . . cord-010119-t1x9gknd 167 1 1 1 CD cord-010119-t1x9gknd 167 2 Emory Emory NNP cord-010119-t1x9gknd 167 3 University University NNP cord-010119-t1x9gknd 167 4 , , , cord-010119-t1x9gknd 167 5 2 2 CD cord-010119-t1x9gknd 167 6 Yale Yale NNP cord-010119-t1x9gknd 167 7 - - HYPH cord-010119-t1x9gknd 167 8 New New NNP cord-010119-t1x9gknd 167 9 Haven Haven NNP cord-010119-t1x9gknd 167 10 Hospital Hospital NNP cord-010119-t1x9gknd 167 11 , , , cord-010119-t1x9gknd 167 12 3 3 CD cord-010119-t1x9gknd 167 13 Yale Yale NNP cord-010119-t1x9gknd 167 14 University University NNP cord-010119-t1x9gknd 167 15 , , , cord-010119-t1x9gknd 167 16 4 4 CD cord-010119-t1x9gknd 167 17 Emory Emory NNP cord-010119-t1x9gknd 167 18 University University NNP cord-010119-t1x9gknd 167 19 School School NNP cord-010119-t1x9gknd 167 20 of of IN cord-010119-t1x9gknd 167 21 Medicine Medicine NNP cord-010119-t1x9gknd 167 22 Background Background NNP cord-010119-t1x9gknd 167 23 / / SYM cord-010119-t1x9gknd 167 24 Case Case NNP cord-010119-t1x9gknd 167 25 Studies Studies NNPS cord-010119-t1x9gknd 167 26 : : : cord-010119-t1x9gknd 167 27 While while IN cord-010119-t1x9gknd 167 28 red red JJ cord-010119-t1x9gknd 167 29 blood blood NN cord-010119-t1x9gknd 167 30 cell cell NN cord-010119-t1x9gknd 167 31 ( ( -LRB- cord-010119-t1x9gknd 167 32 RBC RBC NNP cord-010119-t1x9gknd 167 33 ) ) -RRB- cord-010119-t1x9gknd 167 34 alloantibodies alloantibody NNS cord-010119-t1x9gknd 167 35 can can MD cord-010119-t1x9gknd 167 36 increase increase VB cord-010119-t1x9gknd 167 37 the the DT cord-010119-t1x9gknd 167 38 probability probability NN cord-010119-t1x9gknd 167 39 of of IN cord-010119-t1x9gknd 167 40 transfusion transfusion NN cord-010119-t1x9gknd 167 41 - - HYPH cord-010119-t1x9gknd 167 42 related relate VBN cord-010119-t1x9gknd 167 43 complications complication NNS cord-010119-t1x9gknd 167 44 , , , cord-010119-t1x9gknd 167 45 not not RB cord-010119-t1x9gknd 167 46 all all DT cord-010119-t1x9gknd 167 47 patients patient NNS cord-010119-t1x9gknd 167 48 become become VBP cord-010119-t1x9gknd 167 49 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 167 50 following follow VBG cord-010119-t1x9gknd 167 51 transfusion transfusion NN cord-010119-t1x9gknd 167 52 . . . cord-010119-t1x9gknd 168 1 However however RB cord-010119-t1x9gknd 168 2 , , , cord-010119-t1x9gknd 168 3 individuals individual NNS cord-010119-t1x9gknd 168 4 that that WDT cord-010119-t1x9gknd 168 5 do do VBP cord-010119-t1x9gknd 168 6 generate generate VB cord-010119-t1x9gknd 168 7 alloantibodies alloantibody NNS cord-010119-t1x9gknd 168 8 appear appear VBP cord-010119-t1x9gknd 168 9 to to TO cord-010119-t1x9gknd 168 10 experience experience VB cord-010119-t1x9gknd 168 11 an an DT cord-010119-t1x9gknd 168 12 increased increase VBN cord-010119-t1x9gknd 168 13 rate rate NN cord-010119-t1x9gknd 168 14 of of IN cord-010119-t1x9gknd 168 15 additional additional JJ cord-010119-t1x9gknd 168 16 alloantibody alloantibody NN cord-010119-t1x9gknd 168 17 formation formation NN cord-010119-t1x9gknd 168 18 following follow VBG cord-010119-t1x9gknd 168 19 subsequent subsequent JJ cord-010119-t1x9gknd 168 20 transfusion transfusion NN cord-010119-t1x9gknd 168 21 . . . cord-010119-t1x9gknd 169 1 However however RB cord-010119-t1x9gknd 169 2 , , , cord-010119-t1x9gknd 169 3 how how WRB cord-010119-t1x9gknd 169 4 immunity immunity NN cord-010119-t1x9gknd 169 5 to to IN cord-010119-t1x9gknd 169 6 one one CD cord-010119-t1x9gknd 169 7 RBC RBC NNP cord-010119-t1x9gknd 169 8 alloantigen alloantigen NN cord-010119-t1x9gknd 169 9 primes prime NNS cord-010119-t1x9gknd 169 10 immunization immunization NN cord-010119-t1x9gknd 169 11 to to IN cord-010119-t1x9gknd 169 12 a a DT cord-010119-t1x9gknd 169 13 completely completely RB cord-010119-t1x9gknd 169 14 distinct distinct JJ cord-010119-t1x9gknd 169 15 alloantigen alloantigen NN cord-010119-t1x9gknd 169 16 remains remain VBZ cord-010119-t1x9gknd 169 17 unknown unknown JJ cord-010119-t1x9gknd 169 18 . . . cord-010119-t1x9gknd 170 1 Though Though NNP cord-010119-t1x9gknd 170 2 CD4 CD4 NNP cord-010119-t1x9gknd 170 3 T T NNP cord-010119-t1x9gknd 170 4 cell cell NN cord-010119-t1x9gknd 170 5 help help NN cord-010119-t1x9gknd 170 6 classically classically RB cord-010119-t1x9gknd 170 7 occurs occur VBZ cord-010119-t1x9gknd 170 8 through through IN cord-010119-t1x9gknd 170 9 direct direct JJ cord-010119-t1x9gknd 170 10 recognition recognition NN cord-010119-t1x9gknd 170 11 of of IN cord-010119-t1x9gknd 170 12 a a DT cord-010119-t1x9gknd 170 13 peptide peptide NN cord-010119-t1x9gknd 170 14 that that WDT cord-010119-t1x9gknd 170 15 resides reside VBZ cord-010119-t1x9gknd 170 16 within within IN cord-010119-t1x9gknd 170 17 a a DT cord-010119-t1x9gknd 170 18 target target NN cord-010119-t1x9gknd 170 19 B b NN cord-010119-t1x9gknd 170 20 cell cell NN cord-010119-t1x9gknd 170 21 antigen antigen NN cord-010119-t1x9gknd 170 22 , , , cord-010119-t1x9gknd 170 23 individuals individual NNS cord-010119-t1x9gknd 170 24 who who WP cord-010119-t1x9gknd 170 25 develop develop VBP cord-010119-t1x9gknd 170 26 antibodies antibody NNS cord-010119-t1x9gknd 170 27 toward toward IN cord-010119-t1x9gknd 170 28 one one CD cord-010119-t1x9gknd 170 29 RBC RBC NNP cord-010119-t1x9gknd 170 30 alloantigen alloantigen NN cord-010119-t1x9gknd 170 31 experience experience NN cord-010119-t1x9gknd 170 32 increased increase VBN cord-010119-t1x9gknd 170 33 rates rate NNS cord-010119-t1x9gknd 170 34 of of IN cord-010119-t1x9gknd 170 35 antibody antibody NN cord-010119-t1x9gknd 170 36 formation formation NN cord-010119-t1x9gknd 170 37 against against IN cord-010119-t1x9gknd 170 38 completely completely RB cord-010119-t1x9gknd 170 39 distinct distinct JJ cord-010119-t1x9gknd 170 40 RBC RBC NNP cord-010119-t1x9gknd 170 41 alloantigens alloantigen NNS cord-010119-t1x9gknd 170 42 . . . cord-010119-t1x9gknd 171 1 These these DT cord-010119-t1x9gknd 171 2 observations observation NNS cord-010119-t1x9gknd 171 3 suggest suggest VBP cord-010119-t1x9gknd 171 4 that that IN cord-010119-t1x9gknd 171 5 CD4 CD4 NNP cord-010119-t1x9gknd 171 6 T T NNP cord-010119-t1x9gknd 171 7 cells cell NNS cord-010119-t1x9gknd 171 8 that that WDT cord-010119-t1x9gknd 171 9 respond respond VBP cord-010119-t1x9gknd 171 10 to to IN cord-010119-t1x9gknd 171 11 one one CD cord-010119-t1x9gknd 171 12 alloantigen alloantigen NN cord-010119-t1x9gknd 171 13 may may MD cord-010119-t1x9gknd 171 14 directly directly RB cord-010119-t1x9gknd 171 15 facilitate facilitate VB cord-010119-t1x9gknd 171 16 immunity immunity NN cord-010119-t1x9gknd 171 17 to to IN cord-010119-t1x9gknd 171 18 a a DT cord-010119-t1x9gknd 171 19 completely completely RB cord-010119-t1x9gknd 171 20 distinct distinct JJ cord-010119-t1x9gknd 171 21 RBC RBC NNP cord-010119-t1x9gknd 171 22 alloantigen alloantigen NN cord-010119-t1x9gknd 171 23 . . . cord-010119-t1x9gknd 172 1 Study Study NNP cord-010119-t1x9gknd 172 2 Design Design NNP cord-010119-t1x9gknd 172 3 / / SYM cord-010119-t1x9gknd 172 4 Method method NN cord-010119-t1x9gknd 172 5 : : : cord-010119-t1x9gknd 172 6 B6 b6 NN cord-010119-t1x9gknd 172 7 recipients recipient NNS cord-010119-t1x9gknd 172 8 were be VBD cord-010119-t1x9gknd 172 9 transfused transfuse VBN cord-010119-t1x9gknd 172 10 with with IN cord-010119-t1x9gknd 172 11 KEL KEL NNP cord-010119-t1x9gknd 172 12 RBCs rbc NNS cord-010119-t1x9gknd 172 13 in in IN cord-010119-t1x9gknd 172 14 the the DT cord-010119-t1x9gknd 172 15 presence presence NN cord-010119-t1x9gknd 172 16 or or CC cord-010119-t1x9gknd 172 17 absence absence NN cord-010119-t1x9gknd 172 18 of of IN cord-010119-t1x9gknd 172 19 poly poly NN cord-010119-t1x9gknd 173 1 I -PRON- PRP cord-010119-t1x9gknd 173 2 : : : cord-010119-t1x9gknd 173 3 C C NNP cord-010119-t1x9gknd 173 4 ( ( -LRB- cord-010119-t1x9gknd 173 5 PIC PIC NNP cord-010119-t1x9gknd 173 6 ) ) -RRB- cord-010119-t1x9gknd 173 7 , , , cord-010119-t1x9gknd 173 8 followed follow VBN cord-010119-t1x9gknd 173 9 by by IN cord-010119-t1x9gknd 173 10 transfusion transfusion NN cord-010119-t1x9gknd 173 11 of of IN cord-010119-t1x9gknd 173 12 HOD HOD NNP cord-010119-t1x9gknd 173 13 RBCs rbc NNS cord-010119-t1x9gknd 173 14 , , , cord-010119-t1x9gknd 173 15 KEL KEL NNP cord-010119-t1x9gknd 173 16 RBCs rbc NNS cord-010119-t1x9gknd 173 17 , , , cord-010119-t1x9gknd 173 18 RBCs rbc NNS cord-010119-t1x9gknd 173 19 expressing express VBG cord-010119-t1x9gknd 173 20 HOD HOD NNP cord-010119-t1x9gknd 173 21 and and CC cord-010119-t1x9gknd 173 22 KEL KEL NNP cord-010119-t1x9gknd 173 23 ( ( -LRB- cord-010119-t1x9gknd 173 24 HOD HOD NNP cord-010119-t1x9gknd 173 25 x x SYM cord-010119-t1x9gknd 173 26 KEL KEL NNP cord-010119-t1x9gknd 173 27 ) ) -RRB- cord-010119-t1x9gknd 173 28 , , , cord-010119-t1x9gknd 173 29 or or CC cord-010119-t1x9gknd 173 30 a a DT cord-010119-t1x9gknd 173 31 mixture mixture NN cord-010119-t1x9gknd 173 32 of of IN cord-010119-t1x9gknd 173 33 HOD HOD NNP cord-010119-t1x9gknd 173 34 and and CC cord-010119-t1x9gknd 173 35 KEL KEL NNP cord-010119-t1x9gknd 173 36 RBCs rbc NNS cord-010119-t1x9gknd 173 37 ( ( -LRB- cord-010119-t1x9gknd 173 38 HOD HOD NNP cord-010119-t1x9gknd 173 39 1 1 CD cord-010119-t1x9gknd 173 40 KEL KEL NNP cord-010119-t1x9gknd 173 41 ) ) -RRB- cord-010119-t1x9gknd 173 42 . . . cord-010119-t1x9gknd 174 1 To to TO cord-010119-t1x9gknd 174 2 examine examine VB cord-010119-t1x9gknd 174 3 the the DT cord-010119-t1x9gknd 174 4 role role NN cord-010119-t1x9gknd 174 5 of of IN cord-010119-t1x9gknd 174 6 CD4 CD4 NNP cord-010119-t1x9gknd 174 7 T T NNP cord-010119-t1x9gknd 174 8 cells cell NNS cord-010119-t1x9gknd 174 9 , , , cord-010119-t1x9gknd 174 10 PIC PIC NNP cord-010119-t1x9gknd 174 11 / / SYM cord-010119-t1x9gknd 174 12 KEL KEL NNP cord-010119-t1x9gknd 174 13 primed prime VBD cord-010119-t1x9gknd 174 14 B6 b6 NN cord-010119-t1x9gknd 174 15 recipients recipient NNS cord-010119-t1x9gknd 174 16 were be VBD cord-010119-t1x9gknd 174 17 CD4 CD4 NNP cord-010119-t1x9gknd 174 18 T T NNP cord-010119-t1x9gknd 174 19 cell cell NN cord-010119-t1x9gknd 174 20 depleted deplete VBN cord-010119-t1x9gknd 174 21 prior prior RB cord-010119-t1x9gknd 174 22 to to IN cord-010119-t1x9gknd 174 23 transfusion transfusion NN cord-010119-t1x9gknd 174 24 . . . cord-010119-t1x9gknd 175 1 In in IN cord-010119-t1x9gknd 175 2 addition addition NN cord-010119-t1x9gknd 175 3 , , , cord-010119-t1x9gknd 175 4 B6 b6 NN cord-010119-t1x9gknd 175 5 recipients recipient NNS cord-010119-t1x9gknd 175 6 were be VBD cord-010119-t1x9gknd 175 7 adoptively adoptively RB cord-010119-t1x9gknd 175 8 transferred transfer VBN cord-010119-t1x9gknd 175 9 with with IN cord-010119-t1x9gknd 175 10 CD4 CD4 NNP cord-010119-t1x9gknd 175 11 T T NNP cord-010119-t1x9gknd 175 12 cells cell NNS cord-010119-t1x9gknd 175 13 from from IN cord-010119-t1x9gknd 175 14 na€ na€ JJ cord-010119-t1x9gknd 175 15 ıve ıve NN cord-010119-t1x9gknd 175 16 or or CC cord-010119-t1x9gknd 176 1 PIC PIC NNP cord-010119-t1x9gknd 176 2 / / SYM cord-010119-t1x9gknd 176 3 KEL KEL NNP cord-010119-t1x9gknd 176 4 primed prime VBD cord-010119-t1x9gknd 176 5 donors donor NNS cord-010119-t1x9gknd 176 6 , , , cord-010119-t1x9gknd 176 7 followed follow VBN cord-010119-t1x9gknd 176 8 by by IN cord-010119-t1x9gknd 176 9 transfusion transfusion NN cord-010119-t1x9gknd 176 10 of of IN cord-010119-t1x9gknd 176 11 HOD HOD NNP cord-010119-t1x9gknd 176 12 RBCs rbc NNS cord-010119-t1x9gknd 176 13 or or CC cord-010119-t1x9gknd 176 14 ( ( -LRB- cord-010119-t1x9gknd 176 15 HOD HOD NNP cord-010119-t1x9gknd 176 16 x x SYM cord-010119-t1x9gknd 176 17 KEL KEL NNP cord-010119-t1x9gknd 176 18 ) ) -RRB- cord-010119-t1x9gknd 176 19 RBCs rbc NNS cord-010119-t1x9gknd 176 20 . . . cord-010119-t1x9gknd 177 1 Anti Anti NNP cord-010119-t1x9gknd 177 2 - - NNP cord-010119-t1x9gknd 177 3 HOD HOD NNP cord-010119-t1x9gknd 177 4 and and CC cord-010119-t1x9gknd 177 5 anti anti JJ cord-010119-t1x9gknd 177 6 - - JJ cord-010119-t1x9gknd 177 7 KEL KEL NNP cord-010119-t1x9gknd 177 8 alloantibody alloantibody NN cord-010119-t1x9gknd 177 9 formation formation NN cord-010119-t1x9gknd 177 10 was be VBD cord-010119-t1x9gknd 177 11 evaluated evaluate VBN cord-010119-t1x9gknd 177 12 using use VBG cord-010119-t1x9gknd 177 13 indirect indirect JJ cord-010119-t1x9gknd 177 14 immunofluorescence immunofluorescence NN cord-010119-t1x9gknd 177 15 staining staining NN cord-010119-t1x9gknd 177 16 . . . cord-010119-t1x9gknd 178 1 Results result NNS cord-010119-t1x9gknd 178 2 / / SYM cord-010119-t1x9gknd 178 3 Findings finding NNS cord-010119-t1x9gknd 178 4 : : : cord-010119-t1x9gknd 178 5 KEL KEL NNP cord-010119-t1x9gknd 178 6 RBC RBC NNP cord-010119-t1x9gknd 178 7 transfusion transfusion NN cord-010119-t1x9gknd 178 8 in in IN cord-010119-t1x9gknd 178 9 the the DT cord-010119-t1x9gknd 178 10 presence presence NN cord-010119-t1x9gknd 178 11 of of IN cord-010119-t1x9gknd 178 12 PIC PIC NNP cord-010119-t1x9gknd 178 13 ( ( -LRB- cord-010119-t1x9gknd 178 14 PIC PIC NNP cord-010119-t1x9gknd 178 15 / / SYM cord-010119-t1x9gknd 178 16 KEL KEL NNP cord-010119-t1x9gknd 178 17 ) ) -RRB- cord-010119-t1x9gknd 179 1 not not RB cord-010119-t1x9gknd 179 2 only only RB cord-010119-t1x9gknd 179 3 enhanced enhance VBN cord-010119-t1x9gknd 179 4 anti anti JJ cord-010119-t1x9gknd 179 5 - - JJ cord-010119-t1x9gknd 179 6 KEL KEL NNP cord-010119-t1x9gknd 179 7 antibody antibody NN cord-010119-t1x9gknd 179 8 production production NN cord-010119-t1x9gknd 179 9 through through IN cord-010119-t1x9gknd 179 10 a a DT cord-010119-t1x9gknd 179 11 CD4 CD4 NNP cord-010119-t1x9gknd 179 12 T T NNP cord-010119-t1x9gknd 179 13 celldependent celldependent NN cord-010119-t1x9gknd 179 14 process process NN cord-010119-t1x9gknd 179 15 , , , cord-010119-t1x9gknd 179 16 but but CC cord-010119-t1x9gknd 179 17 this this DT cord-010119-t1x9gknd 179 18 same same JJ cord-010119-t1x9gknd 179 19 priming prime VBG cord-010119-t1x9gknd 179 20 event event NN cord-010119-t1x9gknd 179 21 directly directly RB cord-010119-t1x9gknd 179 22 facilitated facilitate VBN cord-010119-t1x9gknd 179 23 anti anti NNP cord-010119-t1x9gknd 179 24 - - JJ cord-010119-t1x9gknd 179 25 HOD HOD NNP cord-010119-t1x9gknd 179 26 antibody antibody NN cord-010119-t1x9gknd 179 27 formation formation NN cord-010119-t1x9gknd 179 28 following follow VBG cord-010119-t1x9gknd 179 29 subsequent subsequent JJ cord-010119-t1x9gknd 179 30 ( ( -LRB- cord-010119-t1x9gknd 179 31 HOD HOD NNP cord-010119-t1x9gknd 179 32 x x SYM cord-010119-t1x9gknd 179 33 KEL KEL NNP cord-010119-t1x9gknd 179 34 ) ) -RRB- cord-010119-t1x9gknd 179 35 RBC RBC NNP cord-010119-t1x9gknd 179 36 transfusion transfusion NN cord-010119-t1x9gknd 179 37 ( ( -LRB- cord-010119-t1x9gknd 179 38 p p NN cord-010119-t1x9gknd 179 39 < < XX cord-010119-t1x9gknd 179 40 0.001 0.001 CD cord-010119-t1x9gknd 179 41 ) ) -RRB- cord-010119-t1x9gknd 179 42 ; ; : cord-010119-t1x9gknd 179 43 PIC PIC NNP cord-010119-t1x9gknd 179 44 / / SYM cord-010119-t1x9gknd 179 45 KEL KEL NNP cord-010119-t1x9gknd 179 46 primed prime VBD cord-010119-t1x9gknd 179 47 recipients recipient NNS cord-010119-t1x9gknd 179 48 transfused transfuse VBN cord-010119-t1x9gknd 179 49 with with IN cord-010119-t1x9gknd 179 50 ( ( -LRB- cord-010119-t1x9gknd 179 51 HOD HOD NNP cord-010119-t1x9gknd 179 52 1 1 CD cord-010119-t1x9gknd 179 53 KEL KEL NNP cord-010119-t1x9gknd 179 54 ) ) -RRB- cord-010119-t1x9gknd 179 55 RBCs rbc NNS cord-010119-t1x9gknd 179 56 or or CC cord-010119-t1x9gknd 179 57 HOD HOD NNP cord-010119-t1x9gknd 179 58 RBCs rbc NNS cord-010119-t1x9gknd 179 59 alone alone RB cord-010119-t1x9gknd 179 60 failed fail VBD cord-010119-t1x9gknd 179 61 to to TO cord-010119-t1x9gknd 179 62 impact impact VB cord-010119-t1x9gknd 179 63 anti anti NNP cord-010119-t1x9gknd 179 64 - - JJ cord-010119-t1x9gknd 179 65 HOD HOD NNP cord-010119-t1x9gknd 179 66 antibody antibody NN cord-010119-t1x9gknd 179 67 formation formation NN cord-010119-t1x9gknd 179 68 . . . cord-010119-t1x9gknd 180 1 The the DT cord-010119-t1x9gknd 180 2 ability ability NN cord-010119-t1x9gknd 180 3 of of IN cord-010119-t1x9gknd 180 4 immunity immunity NN cord-010119-t1x9gknd 180 5 to to IN cord-010119-t1x9gknd 180 6 KEL KEL NNP cord-010119-t1x9gknd 180 7 to to TO cord-010119-t1x9gknd 180 8 boost boost VB cord-010119-t1x9gknd 180 9 a a DT cord-010119-t1x9gknd 180 10 humoral humoral JJ cord-010119-t1x9gknd 180 11 response response NN cord-010119-t1x9gknd 180 12 to to IN cord-010119-t1x9gknd 180 13 the the DT cord-010119-t1x9gknd 180 14 HOD HOD NNP cord-010119-t1x9gknd 180 15 antigen antigen NN cord-010119-t1x9gknd 180 16 following follow VBG cord-010119-t1x9gknd 180 17 ( ( -LRB- cord-010119-t1x9gknd 180 18 HOD HOD NNP cord-010119-t1x9gknd 180 19 x x SYM cord-010119-t1x9gknd 180 20 KEL KEL NNP cord-010119-t1x9gknd 180 21 ) ) -RRB- cord-010119-t1x9gknd 180 22 RBC RBC NNP cord-010119-t1x9gknd 180 23 transfusion transfusion NN cord-010119-t1x9gknd 180 24 required require VBD cord-010119-t1x9gknd 180 25 KEL KEL NNP cord-010119-t1x9gknd 180 26 priming prime VBG cord-010119-t1x9gknd 180 27 in in IN cord-010119-t1x9gknd 180 28 the the DT cord-010119-t1x9gknd 180 29 presence presence NN cord-010119-t1x9gknd 180 30 of of IN cord-010119-t1x9gknd 180 31 PIC PIC NNP cord-010119-t1x9gknd 180 32 . . . cord-010119-t1x9gknd 181 1 CD4 CD4 NNP cord-010119-t1x9gknd 181 2 T T NNP cord-010119-t1x9gknd 181 3 cell cell NN cord-010119-t1x9gknd 181 4 depletion depletion NN cord-010119-t1x9gknd 181 5 prevented prevent VBD cord-010119-t1x9gknd 181 6 PIC PIC NNP cord-010119-t1x9gknd 181 7 / / SYM cord-010119-t1x9gknd 181 8 KEL KEL NNP cord-010119-t1x9gknd 181 9 primed prime VBD cord-010119-t1x9gknd 181 10 recipients recipient NNS cord-010119-t1x9gknd 181 11 from from IN cord-010119-t1x9gknd 181 12 boosting boost VBG cord-010119-t1x9gknd 181 13 an an DT cord-010119-t1x9gknd 181 14 anti anti JJ cord-010119-t1x9gknd 181 15 - - JJ cord-010119-t1x9gknd 181 16 HOD HOD NNP cord-010119-t1x9gknd 181 17 antibody antibody NN cord-010119-t1x9gknd 181 18 response response NN cord-010119-t1x9gknd 181 19 ( ( -LRB- cord-010119-t1x9gknd 181 20 p p NN cord-010119-t1x9gknd 181 21 < < XX cord-010119-t1x9gknd 181 22 0.0001 0.0001 CD cord-010119-t1x9gknd 181 23 ) ) -RRB- cord-010119-t1x9gknd 181 24 and and CC cord-010119-t1x9gknd 181 25 transfer transfer NN cord-010119-t1x9gknd 181 26 of of IN cord-010119-t1x9gknd 181 27 CD4 CD4 NNP cord-010119-t1x9gknd 181 28 T T NNP cord-010119-t1x9gknd 181 29 cells cell NNS cord-010119-t1x9gknd 181 30 from from IN cord-010119-t1x9gknd 181 31 PIC PIC NNP cord-010119-t1x9gknd 181 32 / / SYM cord-010119-t1x9gknd 181 33 KEL KEL NNP cord-010119-t1x9gknd 181 34 primed prime VBD cord-010119-t1x9gknd 181 35 recipients recipient NNS cord-010119-t1x9gknd 181 36 likewise likewise RB cord-010119-t1x9gknd 181 37 directly directly RB cord-010119-t1x9gknd 181 38 facilitated facilitate VBN cord-010119-t1x9gknd 181 39 anti anti NNP cord-010119-t1x9gknd 181 40 - - JJ cord-010119-t1x9gknd 181 41 HOD HOD NNP cord-010119-t1x9gknd 181 42 antibody antibody NN cord-010119-t1x9gknd 181 43 formation formation NN cord-010119-t1x9gknd 181 44 following follow VBG cord-010119-t1x9gknd 181 45 a a DT cord-010119-t1x9gknd 181 46 ( ( -LRB- cord-010119-t1x9gknd 181 47 HOD HOD NNP cord-010119-t1x9gknd 181 48 x x SYM cord-010119-t1x9gknd 181 49 KEL KEL NNP cord-010119-t1x9gknd 181 50 ) ) -RRB- cord-010119-t1x9gknd 181 51 RBC RBC NNP cord-010119-t1x9gknd 181 52 transfusion transfusion NN cord-010119-t1x9gknd 181 53 ( ( -LRB- cord-010119-t1x9gknd 181 54 p p NN cord-010119-t1x9gknd 181 55 < < XX cord-010119-t1x9gknd 181 56 0.001 0.001 CD cord-010119-t1x9gknd 181 57 ) ) -RRB- cord-010119-t1x9gknd 181 58 . . . cord-010119-t1x9gknd 182 1 Conclusion conclusion NN cord-010119-t1x9gknd 182 2 : : : cord-010119-t1x9gknd 183 1 These these DT cord-010119-t1x9gknd 183 2 results result NNS cord-010119-t1x9gknd 183 3 demonstrate demonstrate VBP cord-010119-t1x9gknd 183 4 that that IN cord-010119-t1x9gknd 183 5 CD4 CD4 NNP cord-010119-t1x9gknd 183 6 T T NNP cord-010119-t1x9gknd 183 7 cells cell NNS cord-010119-t1x9gknd 183 8 primed prime VBN cord-010119-t1x9gknd 183 9 to to IN cord-010119-t1x9gknd 183 10 one one CD cord-010119-t1x9gknd 183 11 RBC RBC NNP cord-010119-t1x9gknd 183 12 alloantigen alloantigen NN cord-010119-t1x9gknd 183 13 can can MD cord-010119-t1x9gknd 183 14 directly directly RB cord-010119-t1x9gknd 183 15 enhance enhance VB cord-010119-t1x9gknd 183 16 the the DT cord-010119-t1x9gknd 183 17 immune immune JJ cord-010119-t1x9gknd 183 18 response response NN cord-010119-t1x9gknd 183 19 to to IN cord-010119-t1x9gknd 183 20 a a DT cord-010119-t1x9gknd 183 21 completely completely RB cord-010119-t1x9gknd 183 22 distinct distinct JJ cord-010119-t1x9gknd 183 23 RBC RBC NNP cord-010119-t1x9gknd 183 24 alloantigen alloantigen NN cord-010119-t1x9gknd 183 25 , , , cord-010119-t1x9gknd 183 26 suggesting suggest VBG cord-010119-t1x9gknd 183 27 a a DT cord-010119-t1x9gknd 183 28 mechanism mechanism NN cord-010119-t1x9gknd 183 29 whereby whereby WRB cord-010119-t1x9gknd 183 30 alloantibody alloantibody NN cord-010119-t1x9gknd 183 31 responders responder NNS cord-010119-t1x9gknd 183 32 may may MD cord-010119-t1x9gknd 183 33 exhibit exhibit VB cord-010119-t1x9gknd 183 34 an an DT cord-010119-t1x9gknd 183 35 increased increase VBN cord-010119-t1x9gknd 183 36 rate rate NN cord-010119-t1x9gknd 183 37 of of IN cord-010119-t1x9gknd 183 38 additional additional JJ cord-010119-t1x9gknd 183 39 alloantibody alloantibody NN cord-010119-t1x9gknd 183 40 Background Background NNP cord-010119-t1x9gknd 183 41 / / SYM cord-010119-t1x9gknd 183 42 Case Case NNP cord-010119-t1x9gknd 183 43 Studies Studies NNPS cord-010119-t1x9gknd 183 44 : : : cord-010119-t1x9gknd 183 45 Platelet platelet NN cord-010119-t1x9gknd 183 46 refractoriness refractoriness NN cord-010119-t1x9gknd 183 47 remains remain VBZ cord-010119-t1x9gknd 183 48 a a DT cord-010119-t1x9gknd 183 49 significant significant JJ cord-010119-t1x9gknd 183 50 clinical clinical JJ cord-010119-t1x9gknd 183 51 problem problem NN cord-010119-t1x9gknd 183 52 , , , cord-010119-t1x9gknd 183 53 yet yet CC cord-010119-t1x9gknd 183 54 the the DT cord-010119-t1x9gknd 183 55 mechanisms mechanism NNS cord-010119-t1x9gknd 183 56 by by IN cord-010119-t1x9gknd 183 57 which which WDT cord-010119-t1x9gknd 183 58 it -PRON- PRP cord-010119-t1x9gknd 183 59 occurs occur VBZ cord-010119-t1x9gknd 183 60 are be VBP cord-010119-t1x9gknd 183 61 incompletely incompletely RB cord-010119-t1x9gknd 183 62 understood understand VBN cord-010119-t1x9gknd 183 63 . . . cord-010119-t1x9gknd 184 1 Immune immune NN cord-010119-t1x9gknd 184 2 - - HYPH cord-010119-t1x9gknd 184 3 mediated mediate VBN cord-010119-t1x9gknd 184 4 platelet platelet NN cord-010119-t1x9gknd 184 5 clearance clearance NN cord-010119-t1x9gknd 184 6 by by IN cord-010119-t1x9gknd 184 7 anti anti JJ cord-010119-t1x9gknd 184 8 - - JJ cord-010119-t1x9gknd 184 9 platelet platelet JJ cord-010119-t1x9gknd 184 10 alloantibodies alloantibody NNS cord-010119-t1x9gknd 184 11 plays play VBZ cord-010119-t1x9gknd 184 12 a a DT cord-010119-t1x9gknd 184 13 significant significant JJ cord-010119-t1x9gknd 184 14 role role NN cord-010119-t1x9gknd 184 15 , , , cord-010119-t1x9gknd 184 16 and and CC cord-010119-t1x9gknd 184 17 patients patient NNS cord-010119-t1x9gknd 184 18 with with IN cord-010119-t1x9gknd 184 19 detectable detectable JJ cord-010119-t1x9gknd 184 20 alloantibodies alloantibody NNS cord-010119-t1x9gknd 184 21 can can MD cord-010119-t1x9gknd 184 22 be be VB cord-010119-t1x9gknd 184 23 managed manage VBN cord-010119-t1x9gknd 184 24 with with IN cord-010119-t1x9gknd 184 25 transfusion transfusion NN cord-010119-t1x9gknd 184 26 of of IN cord-010119-t1x9gknd 184 27 HLA HLA NNP cord-010119-t1x9gknd 184 28 - - HYPH cord-010119-t1x9gknd 184 29 matched match VBN cord-010119-t1x9gknd 184 30 platelets platelet NNS cord-010119-t1x9gknd 184 31 . . . cord-010119-t1x9gknd 185 1 Still still RB cord-010119-t1x9gknd 185 2 , , , cord-010119-t1x9gknd 185 3 many many JJ cord-010119-t1x9gknd 185 4 patients patient NNS cord-010119-t1x9gknd 185 5 are be VBP cord-010119-t1x9gknd 185 6 refractory refractory JJ cord-010119-t1x9gknd 185 7 even even RB cord-010119-t1x9gknd 185 8 after after IN cord-010119-t1x9gknd 185 9 receiving receive VBG cord-010119-t1x9gknd 185 10 HLA HLA NNP cord-010119-t1x9gknd 185 11 - - HYPH cord-010119-t1x9gknd 185 12 matched match VBN cord-010119-t1x9gknd 185 13 platelets platelet NNS cord-010119-t1x9gknd 185 14 . . . cord-010119-t1x9gknd 186 1 It -PRON- PRP cord-010119-t1x9gknd 186 2 was be VBD cord-010119-t1x9gknd 186 3 shown show VBN cord-010119-t1x9gknd 186 4 previously previously RB cord-010119-t1x9gknd 186 5 that that IN cord-010119-t1x9gknd 186 6 CD8 CD8 NNP cord-010119-t1x9gknd 186 7 T T NNP cord-010119-t1x9gknd 186 8 cells cell NNS cord-010119-t1x9gknd 186 9 can can MD cord-010119-t1x9gknd 186 10 play play VB cord-010119-t1x9gknd 186 11 a a DT cord-010119-t1x9gknd 186 12 direct direct JJ cord-010119-t1x9gknd 186 13 role role NN cord-010119-t1x9gknd 186 14 in in IN cord-010119-t1x9gknd 186 15 platelet platelet NN cord-010119-t1x9gknd 186 16 clearance clearance NN cord-010119-t1x9gknd 186 17 , , , cord-010119-t1x9gknd 186 18 as as IN cord-010119-t1x9gknd 186 19 allogeneic allogeneic NN cord-010119-t1x9gknd 186 20 platelets platelet NNS cord-010119-t1x9gknd 186 21 are be VBP cord-010119-t1x9gknd 186 22 cleared clear VBN cord-010119-t1x9gknd 186 23 within within IN cord-010119-t1x9gknd 186 24 24 24 CD cord-010119-t1x9gknd 186 25 hours hour NNS cord-010119-t1x9gknd 186 26 post post NN cord-010119-t1x9gknd 186 27 transfusion transfusion NN cord-010119-t1x9gknd 186 28 in in IN cord-010119-t1x9gknd 186 29 B B NNP cord-010119-t1x9gknd 186 30 celldeficient celldeficient NN cord-010119-t1x9gknd 187 1 mMT mMT NNP cord-010119-t1x9gknd 187 2 recipient recipient NNP cord-010119-t1x9gknd 187 3 mice mice NNP cord-010119-t1x9gknd 187 4 ( ( -LRB- cord-010119-t1x9gknd 187 5 ie ie RB cord-010119-t1x9gknd 187 6 in in IN cord-010119-t1x9gknd 187 7 the the DT cord-010119-t1x9gknd 187 8 absence absence NN cord-010119-t1x9gknd 187 9 of of IN cord-010119-t1x9gknd 187 10 anti anti JJ cord-010119-t1x9gknd 187 11 - - JJ cord-010119-t1x9gknd 187 12 platelet platelet JJ cord-010119-t1x9gknd 187 13 alloantibodies alloantibody NNS cord-010119-t1x9gknd 187 14 ) ) -RRB- cord-010119-t1x9gknd 187 15 and and CC cord-010119-t1x9gknd 187 16 depletion depletion NN cord-010119-t1x9gknd 187 17 of of IN cord-010119-t1x9gknd 187 18 CD8 CD8 NNP cord-010119-t1x9gknd 187 19 T T NNP cord-010119-t1x9gknd 187 20 cells cell NNS cord-010119-t1x9gknd 187 21 prevents prevent VBZ cord-010119-t1x9gknd 187 22 such such JJ cord-010119-t1x9gknd 187 23 clearance clearance NN cord-010119-t1x9gknd 187 24 . . . cord-010119-t1x9gknd 188 1 Since since IN cord-010119-t1x9gknd 188 2 minor minor JJ cord-010119-t1x9gknd 188 3 antigenic antigenic JJ cord-010119-t1x9gknd 188 4 differences difference NNS cord-010119-t1x9gknd 188 5 still still RB cord-010119-t1x9gknd 188 6 exist exist VBP cord-010119-t1x9gknd 188 7 between between IN cord-010119-t1x9gknd 188 8 donor donor NN cord-010119-t1x9gknd 188 9 HLA HLA NNP cord-010119-t1x9gknd 188 10 - - HYPH cord-010119-t1x9gknd 188 11 matched match VBN cord-010119-t1x9gknd 188 12 platelets platelet NNS cord-010119-t1x9gknd 188 13 and and CC cord-010119-t1x9gknd 188 14 a a DT cord-010119-t1x9gknd 188 15 recipient recipient NN cord-010119-t1x9gknd 188 16 , , , cord-010119-t1x9gknd 188 17 we -PRON- PRP cord-010119-t1x9gknd 188 18 hypothesized hypothesize VBD cord-010119-t1x9gknd 188 19 that that IN cord-010119-t1x9gknd 188 20 minor minor JJ cord-010119-t1x9gknd 188 21 antigens antigen NNS cord-010119-t1x9gknd 188 22 alone alone RB cord-010119-t1x9gknd 188 23 may may MD cord-010119-t1x9gknd 188 24 mediate mediate VB cord-010119-t1x9gknd 188 25 clearance clearance NN cord-010119-t1x9gknd 188 26 of of IN cord-010119-t1x9gknd 188 27 otherwise otherwise RB cord-010119-t1x9gknd 188 28 HLA HLA NNP cord-010119-t1x9gknd 188 29 - - HYPH cord-010119-t1x9gknd 188 30 matched match VBN cord-010119-t1x9gknd 188 31 platelets platelet NNS cord-010119-t1x9gknd 188 32 . . . cord-010119-t1x9gknd 189 1 Study Study NNP cord-010119-t1x9gknd 189 2 Design Design NNP cord-010119-t1x9gknd 189 3 / / SYM cord-010119-t1x9gknd 189 4 Method method NN cord-010119-t1x9gknd 189 5 : : : cord-010119-t1x9gknd 189 6 To to TO cord-010119-t1x9gknd 189 7 test test VB cord-010119-t1x9gknd 189 8 whether whether IN cord-010119-t1x9gknd 189 9 minor minor JJ cord-010119-t1x9gknd 189 10 antigens antigen NNS cord-010119-t1x9gknd 189 11 can can MD cord-010119-t1x9gknd 189 12 stimulate stimulate VB cord-010119-t1x9gknd 189 13 CD8 CD8 NNP cord-010119-t1x9gknd 189 14 T T NNP cord-010119-t1x9gknd 189 15 cell cell NN cord-010119-t1x9gknd 189 16 - - HYPH cord-010119-t1x9gknd 189 17 dependent dependent JJ cord-010119-t1x9gknd 189 18 platelet platelet NN cord-010119-t1x9gknd 189 19 clearance clearance NN cord-010119-t1x9gknd 189 20 we -PRON- PRP cord-010119-t1x9gknd 189 21 examined examine VBD cord-010119-t1x9gknd 189 22 platelet platelet NN cord-010119-t1x9gknd 189 23 refractoriness refractoriness NN cord-010119-t1x9gknd 189 24 using use VBG cord-010119-t1x9gknd 189 25 mOva mOva NNP cord-010119-t1x9gknd 189 26 and and CC cord-010119-t1x9gknd 189 27 OTI OTI NNP cord-010119-t1x9gknd 189 28 transgenic transgenic JJ cord-010119-t1x9gknd 189 29 mice mouse NNS cord-010119-t1x9gknd 189 30 . . . cord-010119-t1x9gknd 190 1 Leukoreduced leukoreduced JJ cord-010119-t1x9gknd 190 2 donor donor NN cord-010119-t1x9gknd 190 3 platelets platelet NNS cord-010119-t1x9gknd 190 4 from from IN cord-010119-t1x9gknd 190 5 mOva mOva NNP cord-010119-t1x9gknd 190 6 mice mouse NNS cord-010119-t1x9gknd 190 7 , , , cord-010119-t1x9gknd 190 8 which which WDT cord-010119-t1x9gknd 190 9 express express VBP cord-010119-t1x9gknd 190 10 a a DT cord-010119-t1x9gknd 190 11 membrane membrane NN cord-010119-t1x9gknd 190 12 - - HYPH cord-010119-t1x9gknd 190 13 bound bind VBN cord-010119-t1x9gknd 190 14 form form NN cord-010119-t1x9gknd 190 15 of of IN cord-010119-t1x9gknd 190 16 chicken chicken NN cord-010119-t1x9gknd 190 17 ovalbumin ovalbumin NNS cord-010119-t1x9gknd 190 18 and and CC cord-010119-t1x9gknd 190 19 thus thus RB cord-010119-t1x9gknd 190 20 present present JJ cord-010119-t1x9gknd 190 21 ovalbumin ovalbumin NN cord-010119-t1x9gknd 190 22 peptides peptide NNS cord-010119-t1x9gknd 190 23 complexed complexe VBN cord-010119-t1x9gknd 190 24 with with IN cord-010119-t1x9gknd 190 25 murine murine JJ cord-010119-t1x9gknd 190 26 MHC MHC NNP cord-010119-t1x9gknd 190 27 class class NN cord-010119-t1x9gknd 191 1 I -PRON- PRP cord-010119-t1x9gknd 191 2 H2Kb H2Kb NNP cord-010119-t1x9gknd 191 3 , , , cord-010119-t1x9gknd 191 4 were be VBD cord-010119-t1x9gknd 191 5 labelled label VBN cord-010119-t1x9gknd 191 6 in in IN cord-010119-t1x9gknd 191 7 vivowith vivowith NN cord-010119-t1x9gknd 191 8 the the DT cord-010119-t1x9gknd 191 9 fluorescent fluorescent NN cord-010119-t1x9gknd 191 10 dye dye NN cord-010119-t1x9gknd 191 11 CFSE CFSE NNP cord-010119-t1x9gknd 191 12 and and CC cord-010119-t1x9gknd 191 13 transfused transfuse VBN cord-010119-t1x9gknd 191 14 into into IN cord-010119-t1x9gknd 191 15 wildtype wildtype NN cord-010119-t1x9gknd 191 16 ( ( -LRB- cord-010119-t1x9gknd 191 17 WT WT NNP cord-010119-t1x9gknd 191 18 , , , cord-010119-t1x9gknd 191 19 C57BL/6 C57BL/6 NNP cord-010119-t1x9gknd 191 20 ) ) -RRB- cord-010119-t1x9gknd 191 21 mice mouse NNS cord-010119-t1x9gknd 191 22 or or CC cord-010119-t1x9gknd 191 23 OTI OTI NNP cord-010119-t1x9gknd 191 24 mice mouse NNS cord-010119-t1x9gknd 191 25 , , , cord-010119-t1x9gknd 191 26 whose whose WP$ cord-010119-t1x9gknd 191 27 CD8 CD8 NNP cord-010119-t1x9gknd 191 28 T T NNP cord-010119-t1x9gknd 191 29 cell cell NN cord-010119-t1x9gknd 191 30 receptors receptor NNS cord-010119-t1x9gknd 191 31 recognize recognize VBP cord-010119-t1x9gknd 191 32 a a DT cord-010119-t1x9gknd 191 33 specific specific JJ cord-010119-t1x9gknd 191 34 ovalbumin ovalbumin FW cord-010119-t1x9gknd 191 35 peptide peptide NN cord-010119-t1x9gknd 191 36 in in IN cord-010119-t1x9gknd 191 37 the the DT cord-010119-t1x9gknd 191 38 context context NN cord-010119-t1x9gknd 191 39 of of IN cord-010119-t1x9gknd 191 40 MHC MHC NNP cord-010119-t1x9gknd 191 41 class class NN cord-010119-t1x9gknd 191 42 I -PRON- PRP cord-010119-t1x9gknd 191 43 H2Kb H2Kb NNP cord-010119-t1x9gknd 191 44 . . . cord-010119-t1x9gknd 192 1 In in IN cord-010119-t1x9gknd 192 2 some some DT cord-010119-t1x9gknd 192 3 experiments experiment NNS cord-010119-t1x9gknd 192 4 OTI OTI NNP cord-010119-t1x9gknd 192 5 mice mouse NNS cord-010119-t1x9gknd 192 6 were be VBD cord-010119-t1x9gknd 192 7 primed prime VBN cord-010119-t1x9gknd 192 8 with with IN cord-010119-t1x9gknd 192 9 mOva mOva NNP cord-010119-t1x9gknd 192 10 or or CC cord-010119-t1x9gknd 192 11 WT WT NNP cord-010119-t1x9gknd 192 12 splenocytes splenocytes NNP cord-010119-t1x9gknd 192 13 one one CD cord-010119-t1x9gknd 192 14 week week NN cord-010119-t1x9gknd 192 15 prior prior RB cord-010119-t1x9gknd 192 16 to to IN cord-010119-t1x9gknd 192 17 mOva mOva NNP cord-010119-t1x9gknd 192 18 platelet platelet NN cord-010119-t1x9gknd 192 19 transfusion transfusion NN cord-010119-t1x9gknd 192 20 , , , cord-010119-t1x9gknd 192 21 and and CC cord-010119-t1x9gknd 192 22 in in IN cord-010119-t1x9gknd 192 23 others other NNS cord-010119-t1x9gknd 192 24 WT WT NNP cord-010119-t1x9gknd 192 25 mice mouse NNS cord-010119-t1x9gknd 192 26 were be VBD cord-010119-t1x9gknd 192 27 adoptively adoptively RB cord-010119-t1x9gknd 192 28 transferred transfer VBN cord-010119-t1x9gknd 192 29 with with IN cord-010119-t1x9gknd 192 30 OTI OTI NNP cord-010119-t1x9gknd 192 31 splenocytes splenocytes NNP cord-010119-t1x9gknd 192 32 48 48 CD cord-010119-t1x9gknd 192 33 hours hour NNS cord-010119-t1x9gknd 192 34 before before IN cord-010119-t1x9gknd 192 35 mOva mOva NNP cord-010119-t1x9gknd 192 36 platelet platelet NN cord-010119-t1x9gknd 192 37 transfusion transfusion NN cord-010119-t1x9gknd 192 38 . . . cord-010119-t1x9gknd 193 1 Platelet platelet NN cord-010119-t1x9gknd 193 2 recovery recovery NN cord-010119-t1x9gknd 193 3 was be VBD cord-010119-t1x9gknd 193 4 measured measure VBN cord-010119-t1x9gknd 193 5 immediately immediately RB cord-010119-t1x9gknd 193 6 after after IN cord-010119-t1x9gknd 193 7 transfusion transfusion NN cord-010119-t1x9gknd 193 8 as as RB cord-010119-t1x9gknd 193 9 well well RB cord-010119-t1x9gknd 193 10 as as IN cord-010119-t1x9gknd 193 11 after after IN cord-010119-t1x9gknd 193 12 2 2 CD cord-010119-t1x9gknd 193 13 , , , cord-010119-t1x9gknd 193 14 4 4 CD cord-010119-t1x9gknd 193 15 , , , cord-010119-t1x9gknd 193 16 8 8 CD cord-010119-t1x9gknd 193 17 , , , cord-010119-t1x9gknd 193 18 16 16 CD cord-010119-t1x9gknd 193 19 , , , cord-010119-t1x9gknd 193 20 and and CC cord-010119-t1x9gknd 193 21 24 24 CD cord-010119-t1x9gknd 193 22 hours hour NNS cord-010119-t1x9gknd 193 23 and and CC cord-010119-t1x9gknd 193 24 on on IN cord-010119-t1x9gknd 193 25 days day NNS cord-010119-t1x9gknd 193 26 2 2 CD cord-010119-t1x9gknd 193 27 - - SYM cord-010119-t1x9gknd 193 28 5 5 CD cord-010119-t1x9gknd 193 29 . . . cord-010119-t1x9gknd 194 1 Results/ Results/ . cord-010119-t1x9gknd 195 1 Finding finding NN cord-010119-t1x9gknd 195 2 : : : cord-010119-t1x9gknd 195 3 Transfusion transfusion NN cord-010119-t1x9gknd 195 4 of of IN cord-010119-t1x9gknd 195 5 mOva mOva NNP cord-010119-t1x9gknd 195 6 platelets platelet NNS cord-010119-t1x9gknd 195 7 into into IN cord-010119-t1x9gknd 195 8 OTI OTI NNP cord-010119-t1x9gknd 195 9 mice mouse NNS cord-010119-t1x9gknd 196 1 results result NNS cord-010119-t1x9gknd 196 2 in in IN cord-010119-t1x9gknd 196 3 significant significant JJ cord-010119-t1x9gknd 196 4 platelet platelet NN cord-010119-t1x9gknd 196 5 clearance clearance NN cord-010119-t1x9gknd 196 6 as as IN cord-010119-t1x9gknd 196 7 compared compare VBN cord-010119-t1x9gknd 196 8 to to IN cord-010119-t1x9gknd 196 9 transfusion transfusion NN cord-010119-t1x9gknd 196 10 with with IN cord-010119-t1x9gknd 196 11 WT WT NNP cord-010119-t1x9gknd 196 12 platelets platelet NNS cord-010119-t1x9gknd 196 13 . . . cord-010119-t1x9gknd 197 1 Clearance clearance NN cord-010119-t1x9gknd 197 2 kinetics kinetic NNS cord-010119-t1x9gknd 197 3 demonstrate demonstrate VBP cord-010119-t1x9gknd 197 4 platelet platelet NN cord-010119-t1x9gknd 197 5 loss loss NN cord-010119-t1x9gknd 197 6 starting start VBG cord-010119-t1x9gknd 197 7 after after IN cord-010119-t1x9gknd 197 8 8 8 CD cord-010119-t1x9gknd 197 9 hours hour NNS cord-010119-t1x9gknd 197 10 and and CC cord-010119-t1x9gknd 197 11 peaking peak VBG cord-010119-t1x9gknd 197 12 at at IN cord-010119-t1x9gknd 197 13 24 24 CD cord-010119-t1x9gknd 197 14 hours hour NNS cord-010119-t1x9gknd 197 15 , , , cord-010119-t1x9gknd 197 16 and and CC cord-010119-t1x9gknd 197 17 are be VBP cord-010119-t1x9gknd 197 18 similar similar JJ cord-010119-t1x9gknd 197 19 whether whether IN cord-010119-t1x9gknd 197 20 OTI OTI NNP cord-010119-t1x9gknd 197 21 mice mouse NNS cord-010119-t1x9gknd 197 22 are be VBP cord-010119-t1x9gknd 197 23 na€ na€ VBN cord-010119-t1x9gknd 197 24 ıve ıve JJ cord-010119-t1x9gknd 197 25 or or CC cord-010119-t1x9gknd 197 26 previously previously RB cord-010119-t1x9gknd 197 27 primed prime VBN cord-010119-t1x9gknd 197 28 with with IN cord-010119-t1x9gknd 197 29 mOva mOva NNP cord-010119-t1x9gknd 197 30 splenocytes splenocytes NNP cord-010119-t1x9gknd 197 31 . . . cord-010119-t1x9gknd 198 1 Specifically specifically RB cord-010119-t1x9gknd 198 2 , , , cord-010119-t1x9gknd 198 3 mOva mOva NNP cord-010119-t1x9gknd 198 4 platelet platelet NN cord-010119-t1x9gknd 198 5 recovery recovery NN cord-010119-t1x9gknd 198 6 in in IN cord-010119-t1x9gknd 198 7 OTI OTI NNP cord-010119-t1x9gknd 198 8 recipients recipient NNS cord-010119-t1x9gknd 198 9 is be VBZ cord-010119-t1x9gknd 198 10 28 28 CD cord-010119-t1x9gknd 198 11 - - SYM cord-010119-t1x9gknd 198 12 35 35 CD cord-010119-t1x9gknd 198 13 % % NN cord-010119-t1x9gknd 198 14 versus versus IN cord-010119-t1x9gknd 198 15 > > XX cord-010119-t1x9gknd 198 16 60 60 CD cord-010119-t1x9gknd 198 17 % % NN cord-010119-t1x9gknd 198 18 in in IN cord-010119-t1x9gknd 198 19 WT WT NNP cord-010119-t1x9gknd 198 20 recipients recipient NNS cord-010119-t1x9gknd 198 21 at at IN cord-010119-t1x9gknd 198 22 24 24 CD cord-010119-t1x9gknd 198 23 hours hour NNS cord-010119-t1x9gknd 198 24 ( ( -LRB- cord-010119-t1x9gknd 198 25 p<0.05 p<0.05 CD cord-010119-t1x9gknd 198 26 ) ) -RRB- cord-010119-t1x9gknd 198 27 , , , cord-010119-t1x9gknd 198 28 whereas whereas IN cord-010119-t1x9gknd 198 29 transfusion transfusion NN cord-010119-t1x9gknd 198 30 of of IN cord-010119-t1x9gknd 198 31 WT WT NNP cord-010119-t1x9gknd 198 32 platelets platelet NNS cord-010119-t1x9gknd 198 33 into into IN cord-010119-t1x9gknd 198 34 either either CC cord-010119-t1x9gknd 198 35 OTI OTI NNP cord-010119-t1x9gknd 198 36 or or CC cord-010119-t1x9gknd 198 37 WT WT NNP cord-010119-t1x9gknd 198 38 recipients recipient NNS cord-010119-t1x9gknd 198 39 is be VBZ cord-010119-t1x9gknd 198 40 approximately approximately RB cord-010119-t1x9gknd 198 41 60 60 CD cord-010119-t1x9gknd 198 42 % % NN cord-010119-t1x9gknd 198 43 at at IN cord-010119-t1x9gknd 198 44 24 24 CD cord-010119-t1x9gknd 198 45 hours hour NNS cord-010119-t1x9gknd 198 46 after after IN cord-010119-t1x9gknd 198 47 transfusion transfusion NN cord-010119-t1x9gknd 198 48 . . . cord-010119-t1x9gknd 199 1 Adoptive adoptive JJ cord-010119-t1x9gknd 199 2 transfer transfer NN cord-010119-t1x9gknd 199 3 of of IN cord-010119-t1x9gknd 199 4 OTI OTI NNP cord-010119-t1x9gknd 199 5 CD8 CD8 NNP cord-010119-t1x9gknd 199 6 T T NNP cord-010119-t1x9gknd 199 7 cells cell NNS cord-010119-t1x9gknd 199 8 into into IN cord-010119-t1x9gknd 199 9 WT wt NN cord-010119-t1x9gknd 199 10 mice mouse NNS cord-010119-t1x9gknd 199 11 recapitulates recapitulate VBZ cord-010119-t1x9gknd 199 12 the the DT cord-010119-t1x9gknd 199 13 effect effect NN cord-010119-t1x9gknd 199 14 , , , cord-010119-t1x9gknd 199 15 with with IN cord-010119-t1x9gknd 199 16 significant significant JJ cord-010119-t1x9gknd 199 17 mOva mOva NNP cord-010119-t1x9gknd 199 18 platelet platelet NN cord-010119-t1x9gknd 199 19 clearance clearance NN cord-010119-t1x9gknd 199 20 at at IN cord-010119-t1x9gknd 199 21 24 24 CD cord-010119-t1x9gknd 199 22 hours hour NNS cord-010119-t1x9gknd 199 23 compared compare VBN cord-010119-t1x9gknd 199 24 to to IN cord-010119-t1x9gknd 199 25 WT WT NNP cord-010119-t1x9gknd 199 26 platelet platelet NN cord-010119-t1x9gknd 199 27 clearance clearance NN cord-010119-t1x9gknd 199 28 ( ( -LRB- cord-010119-t1x9gknd 199 29 p<0.05 p<0.05 CD cord-010119-t1x9gknd 199 30 ) ) -RRB- cord-010119-t1x9gknd 199 31 . . . cord-010119-t1x9gknd 200 1 Conclusion conclusion NN cord-010119-t1x9gknd 200 2 : : : cord-010119-t1x9gknd 201 1 This this DT cord-010119-t1x9gknd 201 2 work work NN cord-010119-t1x9gknd 201 3 extends extend VBZ cord-010119-t1x9gknd 201 4 the the DT cord-010119-t1x9gknd 201 5 ability ability NN cord-010119-t1x9gknd 201 6 of of IN cord-010119-t1x9gknd 201 7 CD8 CD8 NNP cord-010119-t1x9gknd 201 8 T T NNP cord-010119-t1x9gknd 201 9 cells cell NNS cord-010119-t1x9gknd 201 10 to to TO cord-010119-t1x9gknd 201 11 mediate mediate VB cord-010119-t1x9gknd 201 12 platelet platelet NN cord-010119-t1x9gknd 201 13 clearance clearance NN cord-010119-t1x9gknd 201 14 to to IN cord-010119-t1x9gknd 201 15 a a DT cord-010119-t1x9gknd 201 16 minor minor JJ cord-010119-t1x9gknd 201 17 antigen antigen NN cord-010119-t1x9gknd 201 18 , , , cord-010119-t1x9gknd 201 19 providing provide VBG cord-010119-t1x9gknd 201 20 insight insight NN cord-010119-t1x9gknd 201 21 into into IN cord-010119-t1x9gknd 201 22 the the DT cord-010119-t1x9gknd 201 23 potential potential JJ cord-010119-t1x9gknd 201 24 etiology etiology NN cord-010119-t1x9gknd 201 25 of of IN cord-010119-t1x9gknd 201 26 platelet platelet NN cord-010119-t1x9gknd 201 27 refractoriness refractoriness NN cord-010119-t1x9gknd 201 28 in in IN cord-010119-t1x9gknd 201 29 patients patient NNS cord-010119-t1x9gknd 201 30 receiving receive VBG cord-010119-t1x9gknd 201 31 HLA HLA NNP cord-010119-t1x9gknd 201 32 - - HYPH cord-010119-t1x9gknd 201 33 matched match VBN cord-010119-t1x9gknd 201 34 products product NNS cord-010119-t1x9gknd 201 35 . . . cord-010119-t1x9gknd 202 1 This this DT cord-010119-t1x9gknd 202 2 study study NN cord-010119-t1x9gknd 202 3 also also RB cord-010119-t1x9gknd 202 4 holds hold VBZ cord-010119-t1x9gknd 202 5 implications implication NNS cord-010119-t1x9gknd 202 6 for for IN cord-010119-t1x9gknd 202 7 the the DT cord-010119-t1x9gknd 202 8 clinical clinical JJ cord-010119-t1x9gknd 202 9 management management NN cord-010119-t1x9gknd 202 10 of of IN cord-010119-t1x9gknd 202 11 any any DT cord-010119-t1x9gknd 202 12 nonantibody nonantibody NN cord-010119-t1x9gknd 202 13 - - HYPH cord-010119-t1x9gknd 202 14 mediated mediate VBN cord-010119-t1x9gknd 202 15 platelet platelet NN cord-010119-t1x9gknd 202 16 refractory refractory JJ cord-010119-t1x9gknd 202 17 patient patient NN cord-010119-t1x9gknd 202 18 , , , cord-010119-t1x9gknd 202 19 as as IN cord-010119-t1x9gknd 202 20 therapies therapy NNS cord-010119-t1x9gknd 202 21 directed direct VBD cord-010119-t1x9gknd 202 22 toward toward IN cord-010119-t1x9gknd 202 23 immunomodulation immunomodulation NN cord-010119-t1x9gknd 202 24 of of IN cord-010119-t1x9gknd 202 25 T T NNP cord-010119-t1x9gknd 202 26 cell cell NN cord-010119-t1x9gknd 202 27 responses response NNS cord-010119-t1x9gknd 202 28 may may MD cord-010119-t1x9gknd 202 29 prove prove VB cord-010119-t1x9gknd 202 30 beneficial beneficial JJ cord-010119-t1x9gknd 202 31 . . . cord-010119-t1x9gknd 202 32 _SP cord-010119-t1x9gknd 203 1 Background Background NNP cord-010119-t1x9gknd 203 2 / / SYM cord-010119-t1x9gknd 203 3 Case Case NNP cord-010119-t1x9gknd 203 4 Studies Studies NNPS cord-010119-t1x9gknd 203 5 : : : cord-010119-t1x9gknd 204 1 Alloimmunization alloimmunization NN cord-010119-t1x9gknd 204 2 against against IN cord-010119-t1x9gknd 204 3 major major JJ cord-010119-t1x9gknd 204 4 histocompatibility histocompatibility NN cord-010119-t1x9gknd 204 5 ( ( -LRB- cord-010119-t1x9gknd 204 6 MHC MHC NNP cord-010119-t1x9gknd 204 7 ) ) -RRB- cord-010119-t1x9gknd 204 8 antigens antigen NNS cord-010119-t1x9gknd 204 9 is be VBZ cord-010119-t1x9gknd 204 10 a a DT cord-010119-t1x9gknd 204 11 common common JJ cord-010119-t1x9gknd 204 12 complication complication NN cord-010119-t1x9gknd 204 13 of of IN cord-010119-t1x9gknd 204 14 transfusion transfusion NN cord-010119-t1x9gknd 204 15 , , , cord-010119-t1x9gknd 204 16 and and CC cord-010119-t1x9gknd 204 17 can can MD cord-010119-t1x9gknd 204 18 negatively negatively RB cord-010119-t1x9gknd 204 19 impact impact VB cord-010119-t1x9gknd 204 20 subsequent subsequent JJ cord-010119-t1x9gknd 204 21 transfusions transfusion NNS cord-010119-t1x9gknd 204 22 and and CC cord-010119-t1x9gknd 204 23 transplants transplant NNS cord-010119-t1x9gknd 204 24 . . . cord-010119-t1x9gknd 205 1 We -PRON- PRP cord-010119-t1x9gknd 205 2 have have VBP cord-010119-t1x9gknd 205 3 previously previously RB cord-010119-t1x9gknd 205 4 demonstrated demonstrate VBN cord-010119-t1x9gknd 205 5 that that IN cord-010119-t1x9gknd 205 6 pathogen pathogen NN cord-010119-t1x9gknd 205 7 reduction reduction NN cord-010119-t1x9gknd 205 8 with with IN cord-010119-t1x9gknd 205 9 riboflavin riboflavin NN cord-010119-t1x9gknd 205 10 and and CC cord-010119-t1x9gknd 205 11 UV uv NN cord-010119-t1x9gknd 205 12 light light NN cord-010119-t1x9gknd 205 13 ( ( -LRB- cord-010119-t1x9gknd 205 14 UV1R uv1r NN cord-010119-t1x9gknd 205 15 ) ) -RRB- cord-010119-t1x9gknd 205 16 is be VBZ cord-010119-t1x9gknd 205 17 effective effective JJ cord-010119-t1x9gknd 205 18 both both CC cord-010119-t1x9gknd 205 19 at at IN cord-010119-t1x9gknd 205 20 rapidly rapidly RB cord-010119-t1x9gknd 205 21 killing kill VBG cord-010119-t1x9gknd 205 22 donor donor NN cord-010119-t1x9gknd 205 23 white white JJ cord-010119-t1x9gknd 205 24 blood blood NN cord-010119-t1x9gknd 205 25 cells cell NNS cord-010119-t1x9gknd 205 26 ( ( -LRB- cord-010119-t1x9gknd 205 27 WBCs wbc NNS cord-010119-t1x9gknd 205 28 ) ) -RRB- cord-010119-t1x9gknd 205 29 and and CC cord-010119-t1x9gknd 205 30 at at IN cord-010119-t1x9gknd 205 31 blocking block VBG cord-010119-t1x9gknd 205 32 their -PRON- PRP$ cord-010119-t1x9gknd 205 33 ability ability NN cord-010119-t1x9gknd 205 34 to to TO cord-010119-t1x9gknd 205 35 stimulate stimulate VB cord-010119-t1x9gknd 205 36 an an DT cord-010119-t1x9gknd 205 37 allogeneic allogeneic NN cord-010119-t1x9gknd 205 38 response response NN cord-010119-t1x9gknd 205 39 in in IN cord-010119-t1x9gknd 205 40 vitro vitro FW cord-010119-t1x9gknd 205 41 . . . cord-010119-t1x9gknd 206 1 Furthermore furthermore RB cord-010119-t1x9gknd 206 2 , , , cord-010119-t1x9gknd 206 3 UV1R uv1r IN cord-010119-t1x9gknd 206 4 treatment treatment NN cord-010119-t1x9gknd 206 5 of of IN cord-010119-t1x9gknd 206 6 allogeneic allogeneic NN cord-010119-t1x9gknd 206 7 platelet platelet JJ cord-010119-t1x9gknd 206 8 rich rich JJ cord-010119-t1x9gknd 206 9 plasma plasma NN cord-010119-t1x9gknd 206 10 ( ( -LRB- cord-010119-t1x9gknd 206 11 PRP prp NN cord-010119-t1x9gknd 206 12 ) ) -RRB- cord-010119-t1x9gknd 206 13 prevents prevent VBZ cord-010119-t1x9gknd 206 14 alloimmunization alloimmunization NN cord-010119-t1x9gknd 206 15 in in IN cord-010119-t1x9gknd 206 16 mice mouse NNS cord-010119-t1x9gknd 206 17 , , , cord-010119-t1x9gknd 206 18 and and CC cord-010119-t1x9gknd 206 19 provides provide VBZ cord-010119-t1x9gknd 206 20 partial partial JJ cord-010119-t1x9gknd 206 21 antigen antigen NN cord-010119-t1x9gknd 206 22 - - HYPH cord-010119-t1x9gknd 206 23 specific specific JJ cord-010119-t1x9gknd 206 24 tolerance tolerance NN cord-010119-t1x9gknd 206 25 to to IN cord-010119-t1x9gknd 206 26 subsequent subsequent JJ cord-010119-t1x9gknd 206 27 transfusions transfusion NNS cord-010119-t1x9gknd 206 28 . . . cord-010119-t1x9gknd 207 1 As as IN cord-010119-t1x9gknd 207 2 cells cell NNS cord-010119-t1x9gknd 207 3 that that WDT cord-010119-t1x9gknd 207 4 die die VBP cord-010119-t1x9gknd 207 5 through through IN cord-010119-t1x9gknd 207 6 different different JJ cord-010119-t1x9gknd 207 7 pathways pathway NNS cord-010119-t1x9gknd 207 8 can can MD cord-010119-t1x9gknd 207 9 be be VB cord-010119-t1x9gknd 207 10 either either CC cord-010119-t1x9gknd 207 11 tolerizing tolerize VBG cord-010119-t1x9gknd 207 12 or or CC cord-010119-t1x9gknd 207 13 inflammatory inflammatory JJ cord-010119-t1x9gknd 207 14 , , , cord-010119-t1x9gknd 207 15 we -PRON- PRP cord-010119-t1x9gknd 207 16 sought seek VBD cord-010119-t1x9gknd 207 17 to to TO cord-010119-t1x9gknd 207 18 determine determine VB cord-010119-t1x9gknd 207 19 which which WDT cord-010119-t1x9gknd 207 20 cell cell NN cord-010119-t1x9gknd 207 21 death death NN cord-010119-t1x9gknd 207 22 pathways pathway NNS cord-010119-t1x9gknd 207 23 are be VBP cord-010119-t1x9gknd 207 24 triggered trigger VBN cord-010119-t1x9gknd 207 25 by by IN cord-010119-t1x9gknd 207 26 UV1R uv1r NN cord-010119-t1x9gknd 207 27 , , , cord-010119-t1x9gknd 207 28 as as RB cord-010119-t1x9gknd 207 29 well well RB cord-010119-t1x9gknd 207 30 as as IN cord-010119-t1x9gknd 207 31 evaluate evaluate VB cord-010119-t1x9gknd 207 32 the the DT cord-010119-t1x9gknd 207 33 immunogenicity immunogenicity NN cord-010119-t1x9gknd 207 34 of of IN cord-010119-t1x9gknd 207 35 PRP PRP NNP cord-010119-t1x9gknd 207 36 containing contain VBG cord-010119-t1x9gknd 207 37 WBCs wbc NNS cord-010119-t1x9gknd 207 38 killed kill VBN cord-010119-t1x9gknd 207 39 by by IN cord-010119-t1x9gknd 207 40 other other JJ cord-010119-t1x9gknd 207 41 methods method NNS cord-010119-t1x9gknd 207 42 . . . cord-010119-t1x9gknd 208 1 Study Study NNP cord-010119-t1x9gknd 208 2 Design Design NNP cord-010119-t1x9gknd 208 3 / / SYM cord-010119-t1x9gknd 208 4 Method method NN cord-010119-t1x9gknd 208 5 : : : cord-010119-t1x9gknd 208 6 WBC WBC NNP cord-010119-t1x9gknd 208 7 - - HYPH cord-010119-t1x9gknd 208 8 rich rich JJ cord-010119-t1x9gknd 208 9 PRP PRP NNP cord-010119-t1x9gknd 208 10 was be VBD cord-010119-t1x9gknd 208 11 prepared prepare VBN cord-010119-t1x9gknd 208 12 from from IN cord-010119-t1x9gknd 208 13 C57Bl/6 C57Bl/6 NNP cord-010119-t1x9gknd 208 14 mouse mouse NN cord-010119-t1x9gknd 208 15 blood blood NN cord-010119-t1x9gknd 208 16 and and CC cord-010119-t1x9gknd 208 17 treated treat VBN cord-010119-t1x9gknd 208 18 with with IN cord-010119-t1x9gknd 208 19 UV1R uv1r NN cord-010119-t1x9gknd 208 20 , , , cord-010119-t1x9gknd 208 21 and and CC cord-010119-t1x9gknd 208 22 WBCs wbc NNS cord-010119-t1x9gknd 208 23 prepared prepare VBN cord-010119-t1x9gknd 208 24 in in IN cord-010119-t1x9gknd 208 25 parallel parallel NN cord-010119-t1x9gknd 208 26 from from IN cord-010119-t1x9gknd 208 27 the the DT cord-010119-t1x9gknd 208 28 same same JJ cord-010119-t1x9gknd 208 29 blood blood NN cord-010119-t1x9gknd 208 30 were be VBD cord-010119-t1x9gknd 208 31 treated treat VBN cord-010119-t1x9gknd 208 32 with with IN cord-010119-t1x9gknd 208 33 known know VBN cord-010119-t1x9gknd 208 34 inducers inducer NNS cord-010119-t1x9gknd 208 35 of of IN cord-010119-t1x9gknd 208 36 either either CC cord-010119-t1x9gknd 208 37 apoptosis apoptosis NN cord-010119-t1x9gknd 208 38 or or CC cord-010119-t1x9gknd 208 39 necrosis necrosis NN cord-010119-t1x9gknd 208 40 . . . cord-010119-t1x9gknd 209 1 Membrane membrane NN cord-010119-t1x9gknd 209 2 integrity integrity NN cord-010119-t1x9gknd 209 3 , , , cord-010119-t1x9gknd 209 4 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 209 5 exposure exposure NN cord-010119-t1x9gknd 209 6 , , , cord-010119-t1x9gknd 209 7 caspase caspase NN cord-010119-t1x9gknd 209 8 activity activity NN cord-010119-t1x9gknd 209 9 , , , cord-010119-t1x9gknd 209 10 and and CC cord-010119-t1x9gknd 209 11 chromatin chromatin NN cord-010119-t1x9gknd 209 12 condensation condensation NN cord-010119-t1x9gknd 209 13 were be VBD cord-010119-t1x9gknd 209 14 evaluated evaluate VBN cord-010119-t1x9gknd 209 15 by by IN cord-010119-t1x9gknd 209 16 flow flow NN cord-010119-t1x9gknd 209 17 cytometry cytometry NN cord-010119-t1x9gknd 209 18 . . . cord-010119-t1x9gknd 210 1 BALB BALB NNP cord-010119-t1x9gknd 210 2 / / SYM cord-010119-t1x9gknd 210 3 c c NN cord-010119-t1x9gknd 210 4 recipients recipient NNS cord-010119-t1x9gknd 210 5 were be VBD cord-010119-t1x9gknd 210 6 transfused transfuse VBN cord-010119-t1x9gknd 210 7 with with IN cord-010119-t1x9gknd 210 8 either either DT cord-010119-t1x9gknd 210 9 UV1R uv1r NN cord-010119-t1x9gknd 210 10 treated treat VBN cord-010119-t1x9gknd 210 11 WBC WBC NNP cord-010119-t1x9gknd 210 12 - - HYPH cord-010119-t1x9gknd 210 13 rich rich JJ cord-010119-t1x9gknd 210 14 PRP prp NN cord-010119-t1x9gknd 210 15 , , , cord-010119-t1x9gknd 210 16 or or CC cord-010119-t1x9gknd 210 17 UV1R UV1R VBD cord-010119-t1x9gknd 210 18 treated treat VBN cord-010119-t1x9gknd 210 19 WBC WBC NNP cord-010119-t1x9gknd 210 20 - - HYPH cord-010119-t1x9gknd 210 21 poor poor JJ cord-010119-t1x9gknd 210 22 PRP PRP NNP cord-010119-t1x9gknd 210 23 either either CC cord-010119-t1x9gknd 210 24 alone alone RB cord-010119-t1x9gknd 210 25 or or CC cord-010119-t1x9gknd 210 26 with with IN cord-010119-t1x9gknd 210 27 added add VBN cord-010119-t1x9gknd 210 28 untreated untreated JJ cord-010119-t1x9gknd 210 29 , , , cord-010119-t1x9gknd 210 30 apoptotic apoptotic JJ cord-010119-t1x9gknd 210 31 , , , cord-010119-t1x9gknd 210 32 or or CC cord-010119-t1x9gknd 210 33 necrotic necrotic JJ cord-010119-t1x9gknd 210 34 WBCs wbc NNS cord-010119-t1x9gknd 210 35 , , , cord-010119-t1x9gknd 210 36 all all DT cord-010119-t1x9gknd 210 37 generated generate VBN cord-010119-t1x9gknd 210 38 from from IN cord-010119-t1x9gknd 210 39 allogeneic allogeneic JJ cord-010119-t1x9gknd 210 40 C57Bl/6 C57Bl/6 NNP cord-010119-t1x9gknd 210 41 donor donor NN cord-010119-t1x9gknd 210 42 blood blood NN cord-010119-t1x9gknd 210 43 . . . cord-010119-t1x9gknd 211 1 A a DT cord-010119-t1x9gknd 211 2 second second JJ cord-010119-t1x9gknd 211 3 transfusion transfusion NN cord-010119-t1x9gknd 211 4 of of IN cord-010119-t1x9gknd 211 5 untreated untreated JJ cord-010119-t1x9gknd 211 6 WBC WBC NNP cord-010119-t1x9gknd 211 7 - - HYPH cord-010119-t1x9gknd 211 8 rich rich JJ cord-010119-t1x9gknd 211 9 C57Bl/6 c57bl/6 POS cord-010119-t1x9gknd 211 10 PRP PRP NNP cord-010119-t1x9gknd 211 11 was be VBD cord-010119-t1x9gknd 211 12 given give VBN cord-010119-t1x9gknd 211 13 2 2 CD cord-010119-t1x9gknd 211 14 weeks week NNS cord-010119-t1x9gknd 211 15 later later RB cord-010119-t1x9gknd 211 16 , , , cord-010119-t1x9gknd 211 17 and and CC cord-010119-t1x9gknd 211 18 alloresponses alloresponse NNS cord-010119-t1x9gknd 211 19 were be VBD cord-010119-t1x9gknd 211 20 compared compare VBN cord-010119-t1x9gknd 211 21 against against IN cord-010119-t1x9gknd 211 22 mice mouse NNS cord-010119-t1x9gknd 211 23 given give VBN cord-010119-t1x9gknd 211 24 no no DT cord-010119-t1x9gknd 211 25 transfusion transfusion NN cord-010119-t1x9gknd 211 26 or or CC cord-010119-t1x9gknd 211 27 only only RB cord-010119-t1x9gknd 211 28 the the DT cord-010119-t1x9gknd 211 29 second second JJ cord-010119-t1x9gknd 211 30 untreated untreated JJ cord-010119-t1x9gknd 211 31 transfusion transfusion NN cord-010119-t1x9gknd 211 32 . . . cord-010119-t1x9gknd 212 1 Results/ Results/ . cord-010119-t1x9gknd 213 1 Finding finding NN cord-010119-t1x9gknd 213 2 : : : cord-010119-t1x9gknd 214 1 UV1R uv1r IN cord-010119-t1x9gknd 214 2 treated treat VBN cord-010119-t1x9gknd 214 3 WBCs wbc NNS cord-010119-t1x9gknd 214 4 have have VBP cord-010119-t1x9gknd 214 5 a a DT cord-010119-t1x9gknd 214 6 pattern pattern NN cord-010119-t1x9gknd 214 7 of of IN cord-010119-t1x9gknd 214 8 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 214 9 exposure exposure NN cord-010119-t1x9gknd 214 10 and and CC cord-010119-t1x9gknd 214 11 loss loss NN cord-010119-t1x9gknd 214 12 of of IN cord-010119-t1x9gknd 214 13 membrane membrane NN cord-010119-t1x9gknd 214 14 integrity integrity NN cord-010119-t1x9gknd 214 15 consistent consistent JJ cord-010119-t1x9gknd 214 16 with with IN cord-010119-t1x9gknd 214 17 early early JJ cord-010119-t1x9gknd 214 18 apoptosis apoptosis NN cord-010119-t1x9gknd 214 19 , , , cord-010119-t1x9gknd 214 20 but but CC cord-010119-t1x9gknd 214 21 fail fail VB cord-010119-t1x9gknd 214 22 to to TO cord-010119-t1x9gknd 214 23 demonstrate demonstrate VB cord-010119-t1x9gknd 214 24 significant significant JJ cord-010119-t1x9gknd 214 25 caspase caspase NN cord-010119-t1x9gknd 214 26 activity activity NN cord-010119-t1x9gknd 214 27 or or CC cord-010119-t1x9gknd 214 28 clear clear JJ cord-010119-t1x9gknd 214 29 chromatin chromatin NN cord-010119-t1x9gknd 214 30 condensation condensation NN cord-010119-t1x9gknd 214 31 . . . cord-010119-t1x9gknd 215 1 Alloantibody alloantibody NN cord-010119-t1x9gknd 215 2 responses response NNS cord-010119-t1x9gknd 215 3 to to IN cord-010119-t1x9gknd 215 4 transfusion transfusion NN cord-010119-t1x9gknd 215 5 were be VBD cord-010119-t1x9gknd 215 6 significantly significantly RB cord-010119-t1x9gknd 215 7 higher high JJR cord-010119-t1x9gknd 215 8 in in IN cord-010119-t1x9gknd 215 9 mice mouse NNS cord-010119-t1x9gknd 215 10 previously previously RB cord-010119-t1x9gknd 215 11 exposed expose VBN cord-010119-t1x9gknd 215 12 to to IN cord-010119-t1x9gknd 215 13 untreated untreated JJ cord-010119-t1x9gknd 215 14 ( ( -LRB- cord-010119-t1x9gknd 215 15 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 215 16 ) ) -RRB- cord-010119-t1x9gknd 215 17 or or CC cord-010119-t1x9gknd 215 18 necrotic necrotic JJ cord-010119-t1x9gknd 215 19 ( ( -LRB- cord-010119-t1x9gknd 215 20 p<0.05 p<0.05 NNS cord-010119-t1x9gknd 215 21 ) ) -RRB- cord-010119-t1x9gknd 215 22 WBCs wbc NNS cord-010119-t1x9gknd 215 23 , , , cord-010119-t1x9gknd 215 24 but but CC cord-010119-t1x9gknd 215 25 not not RB cord-010119-t1x9gknd 215 26 those those DT cord-010119-t1x9gknd 215 27 given give VBN cord-010119-t1x9gknd 215 28 UV1R uv1r NN cord-010119-t1x9gknd 215 29 treated treat VBN cord-010119-t1x9gknd 215 30 or or CC cord-010119-t1x9gknd 215 31 apoptotic apoptotic JJ cord-010119-t1x9gknd 215 32 WBCs wbc NNS cord-010119-t1x9gknd 215 33 . . . cord-010119-t1x9gknd 216 1 Ex Ex NNP cord-010119-t1x9gknd 216 2 vivo vivo NN cord-010119-t1x9gknd 216 3 cytokine cytokine NN cord-010119-t1x9gknd 216 4 responses response NNS cord-010119-t1x9gknd 216 5 to to IN cord-010119-t1x9gknd 216 6 stimulation stimulation NN cord-010119-t1x9gknd 216 7 with with IN cord-010119-t1x9gknd 216 8 C57Bl/6 C57Bl/6 NNPS cord-010119-t1x9gknd 216 9 WBCs wbc NNS cord-010119-t1x9gknd 216 10 were be VBD cord-010119-t1x9gknd 216 11 reduced reduce VBN cord-010119-t1x9gknd 216 12 in in IN cord-010119-t1x9gknd 216 13 recipients recipient NNS cord-010119-t1x9gknd 216 14 of of IN cord-010119-t1x9gknd 216 15 either either DT cord-010119-t1x9gknd 216 16 UV1R uv1r JJ cord-010119-t1x9gknd 216 17 or or CC cord-010119-t1x9gknd 216 18 apoptotic apoptotic JJ cord-010119-t1x9gknd 216 19 WBCs wbc NNS cord-010119-t1x9gknd 216 20 , , , cord-010119-t1x9gknd 216 21 and and CC cord-010119-t1x9gknd 216 22 enhanced enhance VBN cord-010119-t1x9gknd 216 23 in in IN cord-010119-t1x9gknd 216 24 recipients recipient NNS cord-010119-t1x9gknd 216 25 of of IN cord-010119-t1x9gknd 216 26 untreated untreated JJ cord-010119-t1x9gknd 216 27 or or CC cord-010119-t1x9gknd 216 28 necrotic necrotic JJ cord-010119-t1x9gknd 216 29 WBCs wbc NNS cord-010119-t1x9gknd 216 30 . . . cord-010119-t1x9gknd 217 1 Conclusion conclusion NN cord-010119-t1x9gknd 217 2 : : : cord-010119-t1x9gknd 218 1 The the DT cord-010119-t1x9gknd 218 2 mechanism mechanism NN cord-010119-t1x9gknd 218 3 of of IN cord-010119-t1x9gknd 218 4 WBC WBC NNP cord-010119-t1x9gknd 218 5 death death NN cord-010119-t1x9gknd 218 6 following follow VBG cord-010119-t1x9gknd 218 7 UV1R uv1r IN cord-010119-t1x9gknd 218 8 treatment treatment NN cord-010119-t1x9gknd 218 9 shares share NNS cord-010119-t1x9gknd 218 10 some some DT cord-010119-t1x9gknd 218 11 membrane membrane NN cord-010119-t1x9gknd 218 12 characteristics characteristic NNS cord-010119-t1x9gknd 218 13 of of IN cord-010119-t1x9gknd 218 14 early early JJ cord-010119-t1x9gknd 218 15 apoptosis apoptosis NN cord-010119-t1x9gknd 218 16 , , , cord-010119-t1x9gknd 218 17 but but CC cord-010119-t1x9gknd 218 18 is be VBZ cord-010119-t1x9gknd 218 19 distinct distinct JJ cord-010119-t1x9gknd 218 20 from from IN cord-010119-t1x9gknd 218 21 classic classic JJ cord-010119-t1x9gknd 218 22 apoptosis apoptosis NN cord-010119-t1x9gknd 218 23 . . . cord-010119-t1x9gknd 219 1 However however RB cord-010119-t1x9gknd 219 2 , , , cord-010119-t1x9gknd 219 3 both both DT cord-010119-t1x9gknd 219 4 UV1R UV1R VBD cord-010119-t1x9gknd 219 5 treated treat VBN cord-010119-t1x9gknd 219 6 and and CC cord-010119-t1x9gknd 219 7 apoptotic apoptotic JJ cord-010119-t1x9gknd 219 8 WBCs wbc NNS cord-010119-t1x9gknd 219 9 fail fail VBP cord-010119-t1x9gknd 219 10 to to TO cord-010119-t1x9gknd 219 11 trigger trigger VB cord-010119-t1x9gknd 219 12 an an DT cord-010119-t1x9gknd 219 13 alloresponse alloresponse NN cord-010119-t1x9gknd 219 14 , , , cord-010119-t1x9gknd 219 15 and and CC cord-010119-t1x9gknd 219 16 offer offer VB cord-010119-t1x9gknd 219 17 some some DT cord-010119-t1x9gknd 219 18 protection protection NN cord-010119-t1x9gknd 219 19 against against IN cord-010119-t1x9gknd 219 20 subsequent subsequent JJ cord-010119-t1x9gknd 219 21 alloexposures alloexposure NNS cord-010119-t1x9gknd 219 22 . . . cord-010119-t1x9gknd 220 1 Background Background NNP cord-010119-t1x9gknd 220 2 / / SYM cord-010119-t1x9gknd 220 3 Case Case NNP cord-010119-t1x9gknd 220 4 Studies Studies NNPS cord-010119-t1x9gknd 220 5 : : : cord-010119-t1x9gknd 221 1 In in IN cord-010119-t1x9gknd 221 2 mitochondria mitochondrion NNS cord-010119-t1x9gknd 221 3 - - HYPH cord-010119-t1x9gknd 221 4 less less JJR cord-010119-t1x9gknd 221 5 red red JJ cord-010119-t1x9gknd 221 6 blood blood NN cord-010119-t1x9gknd 221 7 cells cell NNS cord-010119-t1x9gknd 221 8 ( ( -LRB- cord-010119-t1x9gknd 221 9 RBCs rbc NNS cord-010119-t1x9gknd 221 10 ) ) -RRB- cord-010119-t1x9gknd 221 11 , , , cord-010119-t1x9gknd 221 12 oxygen oxygen NN cord-010119-t1x9gknd 221 13 is be VBZ cord-010119-t1x9gknd 221 14 the the DT cord-010119-t1x9gknd 221 15 main main JJ cord-010119-t1x9gknd 221 16 substrate substrate NN cord-010119-t1x9gknd 221 17 for for IN cord-010119-t1x9gknd 221 18 oxidative oxidative JJ cord-010119-t1x9gknd 221 19 reactions reaction NNS cord-010119-t1x9gknd 221 20 and and CC cord-010119-t1x9gknd 221 21 resulting result VBG cord-010119-t1x9gknd 221 22 oxidative oxidative JJ cord-010119-t1x9gknd 221 23 damage damage NN cord-010119-t1x9gknd 221 24 is be VBZ cord-010119-t1x9gknd 221 25 considered consider VBN cord-010119-t1x9gknd 221 26 as as IN cord-010119-t1x9gknd 221 27 one one CD cord-010119-t1x9gknd 221 28 of of IN cord-010119-t1x9gknd 221 29 the the DT cord-010119-t1x9gknd 221 30 major major JJ cord-010119-t1x9gknd 221 31 causative causative JJ cord-010119-t1x9gknd 221 32 factors factor NNS cord-010119-t1x9gknd 221 33 in in IN cord-010119-t1x9gknd 221 34 the the DT cord-010119-t1x9gknd 221 35 development development NN cord-010119-t1x9gknd 221 36 of of IN cord-010119-t1x9gknd 221 37 RBC RBC NNP cord-010119-t1x9gknd 221 38 storage storage NN cord-010119-t1x9gknd 221 39 lesion lesion NN cord-010119-t1x9gknd 221 40 . . . cord-010119-t1x9gknd 222 1 Oxygen oxygen NN cord-010119-t1x9gknd 222 2 saturation saturation NN cord-010119-t1x9gknd 222 3 ( ( -LRB- cord-010119-t1x9gknd 222 4 SO so RB cord-010119-t1x9gknd 222 5 2 2 CD cord-010119-t1x9gknd 222 6 ) ) -RRB- cord-010119-t1x9gknd 222 7 of of IN cord-010119-t1x9gknd 222 8 venous venous JJ cord-010119-t1x9gknd 222 9 blood blood NN cord-010119-t1x9gknd 222 10 is be VBZ cord-010119-t1x9gknd 222 11 generally generally RB cord-010119-t1x9gknd 222 12 assumed assume VBN cord-010119-t1x9gknd 222 13 to to TO cord-010119-t1x9gknd 222 14 be be VB cord-010119-t1x9gknd 222 15 around around RB cord-010119-t1x9gknd 222 16 70 70 CD cord-010119-t1x9gknd 222 17 - - SYM cord-010119-t1x9gknd 222 18 80 80 CD cord-010119-t1x9gknd 222 19 % % NN cord-010119-t1x9gknd 222 20 as as IN cord-010119-t1x9gknd 222 21 measured measure VBN cord-010119-t1x9gknd 222 22 from from IN cord-010119-t1x9gknd 222 23 a a DT cord-010119-t1x9gknd 222 24 central central JJ cord-010119-t1x9gknd 222 25 venous venous JJ cord-010119-t1x9gknd 222 26 line line NN cord-010119-t1x9gknd 222 27 . . . cord-010119-t1x9gknd 223 1 However however RB cord-010119-t1x9gknd 223 2 , , , cord-010119-t1x9gknd 223 3 a a DT cord-010119-t1x9gknd 223 4 recent recent JJ cord-010119-t1x9gknd 223 5 investigation investigation NN cord-010119-t1x9gknd 223 6 of of IN cord-010119-t1x9gknd 223 7 SO so RB cord-010119-t1x9gknd 223 8 2 2 CD cord-010119-t1x9gknd 223 9 levels level NNS cord-010119-t1x9gknd 223 10 in in IN cord-010119-t1x9gknd 223 11 freshly freshly RB cord-010119-t1x9gknd 223 12 prepared prepare VBN cord-010119-t1x9gknd 223 13 leukocyte leukocyte NN cord-010119-t1x9gknd 223 14 - - HYPH cord-010119-t1x9gknd 223 15 reduced reduce VBN cord-010119-t1x9gknd 223 16 red red JJ cord-010119-t1x9gknd 223 17 cell cell NN cord-010119-t1x9gknd 223 18 concentrates concentrate VBZ cord-010119-t1x9gknd 224 1 ( ( -LRB- cord-010119-t1x9gknd 224 2 LR LR NNP cord-010119-t1x9gknd 224 3 - - HYPH cord-010119-t1x9gknd 224 4 RCCs RCCs NNP cord-010119-t1x9gknd 224 5 ) ) -RRB- cord-010119-t1x9gknd 224 6 revealed reveal VBD cord-010119-t1x9gknd 224 7 unexpectedly unexpectedly RB cord-010119-t1x9gknd 224 8 wide wide JJ cord-010119-t1x9gknd 224 9 SO so RB cord-010119-t1x9gknd 224 10 2 2 CD cord-010119-t1x9gknd 224 11 distribution distribution NN cord-010119-t1x9gknd 224 12 ( ( -LRB- cord-010119-t1x9gknd 224 13 mean mean VB cord-010119-t1x9gknd 224 14 45.9%617.5 45.9%617.5 CD cord-010119-t1x9gknd 224 15 % % NN cord-010119-t1x9gknd 225 1 [ [ -LRB- cord-010119-t1x9gknd 225 2 Yoshida Yoshida NNP cord-010119-t1x9gknd 225 3 et et NNP cord-010119-t1x9gknd 225 4 al al NNP cord-010119-t1x9gknd 225 5 . . . cord-010119-t1x9gknd 225 6 2017 2017 CD cord-010119-t1x9gknd 225 7 ; ; : cord-010119-t1x9gknd 225 8 Blood blood NN cord-010119-t1x9gknd 225 9 Transfusion transfusion NN cord-010119-t1x9gknd 225 10 15 15 CD cord-010119-t1x9gknd 225 11 , , , cord-010119-t1x9gknd 225 12 172 172 CD cord-010119-t1x9gknd 225 13 ] ] -RRB- cord-010119-t1x9gknd 225 14 . . . cord-010119-t1x9gknd 226 1 The the DT cord-010119-t1x9gknd 226 2 present present JJ cord-010119-t1x9gknd 226 3 study study NN cord-010119-t1x9gknd 226 4 was be VBD cord-010119-t1x9gknd 226 5 undertaken undertake VBN cord-010119-t1x9gknd 226 6 to to TO cord-010119-t1x9gknd 226 7 determine determine VB cord-010119-t1x9gknd 226 8 the the DT cord-010119-t1x9gknd 226 9 distribution distribution NN cord-010119-t1x9gknd 226 10 of of IN cord-010119-t1x9gknd 226 11 SO so RB cord-010119-t1x9gknd 226 12 2 2 CD cord-010119-t1x9gknd 226 13 in in IN cord-010119-t1x9gknd 226 14 LR LR NNP cord-010119-t1x9gknd 226 15 - - HYPH cord-010119-t1x9gknd 226 16 RCC RCC NNP cord-010119-t1x9gknd 226 17 produced produce VBD cord-010119-t1x9gknd 226 18 at at IN cord-010119-t1x9gknd 226 19 a a DT cord-010119-t1x9gknd 226 20 medium medium JJ cord-010119-t1x9gknd 226 21 - - HYPH cord-010119-t1x9gknd 226 22 size size NN cord-010119-t1x9gknd 226 23 blood blood NN cord-010119-t1x9gknd 226 24 center center NN cord-010119-t1x9gknd 226 25 using use VBG cord-010119-t1x9gknd 226 26 a a DT cord-010119-t1x9gknd 226 27 novel novel JJ cord-010119-t1x9gknd 226 28 non non JJ cord-010119-t1x9gknd 226 29 - - JJ cord-010119-t1x9gknd 226 30 invasive invasive JJ cord-010119-t1x9gknd 226 31 SO so RB cord-010119-t1x9gknd 226 32 2 2 CD cord-010119-t1x9gknd 226 33 probe probe NN cord-010119-t1x9gknd 226 34 . . . cord-010119-t1x9gknd 227 1 Additionally additionally RB cord-010119-t1x9gknd 227 2 , , , cord-010119-t1x9gknd 227 3 quantitative quantitative JJ cord-010119-t1x9gknd 227 4 metabolomics metabolomic NNS cord-010119-t1x9gknd 227 5 were be VBD cord-010119-t1x9gknd 227 6 carried carry VBN cord-010119-t1x9gknd 227 7 out out RP cord-010119-t1x9gknd 227 8 to to TO cord-010119-t1x9gknd 227 9 examine examine VB cord-010119-t1x9gknd 227 10 the the DT cord-010119-t1x9gknd 227 11 redox redox JJ cord-010119-t1x9gknd 227 12 status status NN cord-010119-t1x9gknd 227 13 of of IN cord-010119-t1x9gknd 227 14 the the DT cord-010119-t1x9gknd 227 15 stored store VBN cord-010119-t1x9gknd 227 16 RBC RBC NNP cord-010119-t1x9gknd 227 17 under under IN cord-010119-t1x9gknd 227 18 various various JJ cord-010119-t1x9gknd 227 19 SO so RB cord-010119-t1x9gknd 227 20 2 2 CD cord-010119-t1x9gknd 227 21 levels level NNS cord-010119-t1x9gknd 227 22 . . . cord-010119-t1x9gknd 228 1 Study Study NNP cord-010119-t1x9gknd 228 2 Design Design NNP cord-010119-t1x9gknd 228 3 / / SYM cord-010119-t1x9gknd 228 4 Method method NN cord-010119-t1x9gknd 228 5 : : : cord-010119-t1x9gknd 229 1 The the DT cord-010119-t1x9gknd 229 2 SO so RB cord-010119-t1x9gknd 229 3 2 2 CD cord-010119-t1x9gknd 229 4 from from IN cord-010119-t1x9gknd 229 5 977 977 CD cord-010119-t1x9gknd 229 6 units unit NNS cord-010119-t1x9gknd 229 7 of of IN cord-010119-t1x9gknd 229 8 LR LR NNP cord-010119-t1x9gknd 229 9 - - HYPH cord-010119-t1x9gknd 229 10 RCC RCC NNP cord-010119-t1x9gknd 229 11 were be VBD cord-010119-t1x9gknd 229 12 examined examine VBN cord-010119-t1x9gknd 229 13 on on IN cord-010119-t1x9gknd 229 14 five five CD cord-010119-t1x9gknd 229 15 consecutive consecutive JJ cord-010119-t1x9gknd 229 16 days day NNS cord-010119-t1x9gknd 229 17 representing represent VBG cord-010119-t1x9gknd 229 18 78 78 CD cord-010119-t1x9gknd 229 19 % % NN cord-010119-t1x9gknd 229 20 of of IN cord-010119-t1x9gknd 229 21 the the DT cord-010119-t1x9gknd 229 22 collected collect VBN cord-010119-t1x9gknd 229 23 units unit NNS cord-010119-t1x9gknd 229 24 during during IN cord-010119-t1x9gknd 229 25 the the DT cord-010119-t1x9gknd 229 26 period period NN cord-010119-t1x9gknd 229 27 at at IN cord-010119-t1x9gknd 229 28 a a DT cord-010119-t1x9gknd 229 29 regional regional JJ cord-010119-t1x9gknd 229 30 blood blood NN cord-010119-t1x9gknd 229 31 center center NN cord-010119-t1x9gknd 229 32 where where WRB cord-010119-t1x9gknd 229 33 all all PDT cord-010119-t1x9gknd 229 34 the the DT cord-010119-t1x9gknd 229 35 units unit NNS cord-010119-t1x9gknd 229 36 were be VBD cord-010119-t1x9gknd 229 37 processed process VBN cord-010119-t1x9gknd 229 38 at at IN cord-010119-t1x9gknd 229 39 room room NN cord-010119-t1x9gknd 229 40 temperature temperature NN cord-010119-t1x9gknd 229 41 within within IN cord-010119-t1x9gknd 229 42 8 8 CD cord-010119-t1x9gknd 229 43 hours hour NNS cord-010119-t1x9gknd 229 44 of of IN cord-010119-t1x9gknd 229 45 blood blood NN cord-010119-t1x9gknd 229 46 collection collection NN cord-010119-t1x9gknd 229 47 . . . cord-010119-t1x9gknd 230 1 SO so RB cord-010119-t1x9gknd 230 2 2 2 CD cord-010119-t1x9gknd 230 3 was be VBD cord-010119-t1x9gknd 230 4 measured measure VBN cord-010119-t1x9gknd 230 5 noninvasively noninvasively RB cord-010119-t1x9gknd 230 6 through through IN cord-010119-t1x9gknd 230 7 the the DT cord-010119-t1x9gknd 230 8 PVC pvc NN cord-010119-t1x9gknd 230 9 bag bag NN cord-010119-t1x9gknd 230 10 immediately immediately RB cord-010119-t1x9gknd 230 11 prior prior RB cord-010119-t1x9gknd 230 12 to to IN cord-010119-t1x9gknd 230 13 refrigeration refrigeration NN cord-010119-t1x9gknd 230 14 by by IN cord-010119-t1x9gknd 230 15 employing employ VBG cord-010119-t1x9gknd 230 16 a a DT cord-010119-t1x9gknd 230 17 Resonance Resonance NNP cord-010119-t1x9gknd 230 18 Raman raman NN cord-010119-t1x9gknd 230 19 spectrometry spectrometry NN cord-010119-t1x9gknd 230 20 ( ( -LRB- cord-010119-t1x9gknd 230 21 Pendar Pendar NNP cord-010119-t1x9gknd 230 22 Microvascular Microvascular NNP cord-010119-t1x9gknd 230 23 Oximeter Oximeter NNP cord-010119-t1x9gknd 230 24 A3U11 A3U11 NNP cord-010119-t1x9gknd 230 25 ; ; : cord-010119-t1x9gknd 230 26 Pendar Pendar NNP cord-010119-t1x9gknd 230 27 Technologies Technologies NNP cord-010119-t1x9gknd 230 28 , , , cord-010119-t1x9gknd 230 29 Cambridge Cambridge NNP cord-010119-t1x9gknd 230 30 MA MA NNP cord-010119-t1x9gknd 230 31 ) ) -RRB- cord-010119-t1x9gknd 230 32 . . . cord-010119-t1x9gknd 231 1 In in IN cord-010119-t1x9gknd 231 2 addition addition NN cord-010119-t1x9gknd 231 3 to to IN cord-010119-t1x9gknd 231 4 SO so RB cord-010119-t1x9gknd 231 5 2 2 CD cord-010119-t1x9gknd 231 6 , , , cord-010119-t1x9gknd 231 7 process process NN cord-010119-t1x9gknd 231 8 methods method NNS cord-010119-t1x9gknd 231 9 , , , cord-010119-t1x9gknd 231 10 RCC RCC NNP cord-010119-t1x9gknd 231 11 volumes volume NNS cord-010119-t1x9gknd 231 12 , , , cord-010119-t1x9gknd 231 13 blood blood NN cord-010119-t1x9gknd 231 14 types type NNS cord-010119-t1x9gknd 231 15 , , , cord-010119-t1x9gknd 231 16 gender gender NN cord-010119-t1x9gknd 231 17 and and CC cord-010119-t1x9gknd 231 18 process process NN cord-010119-t1x9gknd 231 19 times time NNS cord-010119-t1x9gknd 231 20 were be VBD cord-010119-t1x9gknd 231 21 recorded record VBN cord-010119-t1x9gknd 231 22 for for IN cord-010119-t1x9gknd 231 23 analyses analysis NNS cord-010119-t1x9gknd 231 24 . . . cord-010119-t1x9gknd 232 1 In in IN cord-010119-t1x9gknd 232 2 a a DT cord-010119-t1x9gknd 232 3 separate separate JJ cord-010119-t1x9gknd 232 4 study study NN cord-010119-t1x9gknd 232 5 , , , cord-010119-t1x9gknd 232 6 LR LR NNP cord-010119-t1x9gknd 232 7 - - HYPH cord-010119-t1x9gknd 232 8 RCC RCC NNP cord-010119-t1x9gknd 232 9 ( ( -LRB- cord-010119-t1x9gknd 232 10 n54 n54 NN cord-010119-t1x9gknd 232 11 ) ) -RRB- cord-010119-t1x9gknd 232 12 from from IN cord-010119-t1x9gknd 232 13 human human JJ cord-010119-t1x9gknd 232 14 volunteers volunteer NNS cord-010119-t1x9gknd 232 15 were be VBD cord-010119-t1x9gknd 232 16 stored store VBN cord-010119-t1x9gknd 232 17 in in IN cord-010119-t1x9gknd 232 18 AS-3 AS-3 NNP cord-010119-t1x9gknd 232 19 under under IN cord-010119-t1x9gknd 232 20 normoxic normoxic JJ cord-010119-t1x9gknd 232 21 , , , cord-010119-t1x9gknd 232 22 hyperoxic hyperoxic JJ cord-010119-t1x9gknd 232 23 , , , cord-010119-t1x9gknd 232 24 or or CC cord-010119-t1x9gknd 232 25 hypoxic hypoxic JJ cord-010119-t1x9gknd 232 26 conditions condition NNS cord-010119-t1x9gknd 232 27 for for IN cord-010119-t1x9gknd 232 28 up up IN cord-010119-t1x9gknd 232 29 to to TO cord-010119-t1x9gknd 232 30 42 42 CD cord-010119-t1x9gknd 232 31 days day NNS cord-010119-t1x9gknd 232 32 ( ( -LRB- cord-010119-t1x9gknd 232 33 SO so RB cord-010119-t1x9gknd 232 34 2 2 CD cord-010119-t1x9gknd 232 35 ranging range VBG cord-010119-t1x9gknd 232 36 from from IN cord-010119-t1x9gknd 232 37 <3 <3 NN cord-010119-t1x9gknd 232 38 to to IN cord-010119-t1x9gknd 232 39 > > XX cord-010119-t1x9gknd 232 40 95 95 CD cord-010119-t1x9gknd 232 41 % % NN cord-010119-t1x9gknd 232 42 ) ) -RRB- cord-010119-t1x9gknd 232 43 prior prior RB cord-010119-t1x9gknd 232 44 to to IN cord-010119-t1x9gknd 232 45 UHPLC UHPLC NNP cord-010119-t1x9gknd 232 46 - - HYPH cord-010119-t1x9gknd 232 47 MS MS NNP cord-010119-t1x9gknd 232 48 metabolomics metabolomic VBZ cord-010119-t1x9gknd 232 49 analyses analysis NNS cord-010119-t1x9gknd 232 50 in in IN cord-010119-t1x9gknd 232 51 presence presence NN cord-010119-t1x9gknd 232 52 of of IN cord-010119-t1x9gknd 232 53 13 13 CD cord-010119-t1x9gknd 232 54 C C NNP cord-010119-t1x9gknd 232 55 , , , cord-010119-t1x9gknd 232 56 15 15 CD cord-010119-t1x9gknd 232 57 N n CD cord-010119-t1x9gknd 232 58 or or CC cord-010119-t1x9gknd 232 59 deuterated deuterate VBN cord-010119-t1x9gknd 232 60 internal internal JJ cord-010119-t1x9gknd 232 61 stable stable JJ cord-010119-t1x9gknd 232 62 - - HYPH cord-010119-t1x9gknd 232 63 isotope isotope NN cord-010119-t1x9gknd 232 64 labeled label VBN cord-010119-t1x9gknd 232 65 standards standard NNS cord-010119-t1x9gknd 232 66 for for IN cord-010119-t1x9gknd 232 67 absolute absolute JJ cord-010119-t1x9gknd 232 68 quantitation quantitation NN cord-010119-t1x9gknd 232 69 . . . cord-010119-t1x9gknd 233 1 Results/ Results/ . cord-010119-t1x9gknd 234 1 Finding finding NN cord-010119-t1x9gknd 234 2 : : : cord-010119-t1x9gknd 235 1 Measurements measurement NNS cord-010119-t1x9gknd 235 2 of of IN cord-010119-t1x9gknd 235 3 SO so RB cord-010119-t1x9gknd 235 4 2 2 CD cord-010119-t1x9gknd 235 5 carried carry VBD cord-010119-t1x9gknd 235 6 out out RP cord-010119-t1x9gknd 235 7 non non NN cord-010119-t1x9gknd 235 8 - - JJ cord-010119-t1x9gknd 235 9 invasively invasively RB cord-010119-t1x9gknd 235 10 at at IN cord-010119-t1x9gknd 235 11 a a DT cord-010119-t1x9gknd 235 12 blood blood NN cord-010119-t1x9gknd 235 13 center center NN cord-010119-t1x9gknd 235 14 yielded yield VBD cord-010119-t1x9gknd 235 15 a a DT cord-010119-t1x9gknd 235 16 similar similar JJ cord-010119-t1x9gknd 235 17 wide wide JJ cord-010119-t1x9gknd 235 18 distribution distribution NN cord-010119-t1x9gknd 235 19 as as IN cord-010119-t1x9gknd 235 20 previous previous JJ cord-010119-t1x9gknd 235 21 study study NN cord-010119-t1x9gknd 235 22 from from IN cord-010119-t1x9gknd 235 23 497 497 CD cord-010119-t1x9gknd 235 24 units unit NNS cord-010119-t1x9gknd 235 25 of of IN cord-010119-t1x9gknd 235 26 LR LR NNP cord-010119-t1x9gknd 235 27 - - HYPH cord-010119-t1x9gknd 235 28 RCC RCC NNP cord-010119-t1x9gknd 235 29 procured procure VBD cord-010119-t1x9gknd 235 30 and and CC cord-010119-t1x9gknd 235 31 sampled sample VBN cord-010119-t1x9gknd 235 32 invasively invasively RB cord-010119-t1x9gknd 235 33 within within IN cord-010119-t1x9gknd 235 34 24 24 CD cord-010119-t1x9gknd 235 35 hours hour NNS cord-010119-t1x9gknd 235 36 after after IN cord-010119-t1x9gknd 235 37 blood blood NN cord-010119-t1x9gknd 235 38 collection collection NN cord-010119-t1x9gknd 236 1 [ [ -LRB- cord-010119-t1x9gknd 236 2 Yoshida Yoshida NNP cord-010119-t1x9gknd 236 3 ibid ibid NN cord-010119-t1x9gknd 236 4 ] ] -RRB- cord-010119-t1x9gknd 236 5 . . . cord-010119-t1x9gknd 237 1 The the DT cord-010119-t1x9gknd 237 2 shape shape NN cord-010119-t1x9gknd 237 3 of of IN cord-010119-t1x9gknd 237 4 the the DT cord-010119-t1x9gknd 237 5 SO so RB cord-010119-t1x9gknd 237 6 2 2 CD cord-010119-t1x9gknd 237 7 distribution distribution NN cord-010119-t1x9gknd 237 8 appeared appear VBD cord-010119-t1x9gknd 237 9 near near IN cord-010119-t1x9gknd 237 10 normal normal JJ cord-010119-t1x9gknd 237 11 with with IN cord-010119-t1x9gknd 237 12 the the DT cord-010119-t1x9gknd 237 13 mean mean NN cord-010119-t1x9gknd 237 14 of of IN cord-010119-t1x9gknd 237 15 47.0%621.0 47.0%621.0 CD cord-010119-t1x9gknd 237 16 % % NN cord-010119-t1x9gknd 237 17 , , , cord-010119-t1x9gknd 237 18 median median JJ cord-010119-t1x9gknd 237 19 45.2 45.2 CD cord-010119-t1x9gknd 237 20 % % NN cord-010119-t1x9gknd 237 21 , , , cord-010119-t1x9gknd 237 22 range range VBP cord-010119-t1x9gknd 237 23 < < XX cord-010119-t1x9gknd 237 24 5 5 CD cord-010119-t1x9gknd 237 25 % % NN cord-010119-t1x9gknd 237 26 to to IN cord-010119-t1x9gknd 237 27 > > XX cord-010119-t1x9gknd 237 28 95 95 CD cord-010119-t1x9gknd 237 29 % % NN cord-010119-t1x9gknd 237 30 and and CC cord-010119-t1x9gknd 237 31 inter inter JJ cord-010119-t1x9gknd 237 32 - - JJ cord-010119-t1x9gknd 237 33 quartile quartile JJ cord-010119-t1x9gknd 237 34 range range NN cord-010119-t1x9gknd 237 35 ( ( -LRB- cord-010119-t1x9gknd 237 36 IQR IQR NNP cord-010119-t1x9gknd 237 37 ) ) -RRB- cord-010119-t1x9gknd 237 38 of of IN cord-010119-t1x9gknd 237 39 31.4%-61.9 31.4%-61.9 CD cord-010119-t1x9gknd 237 40 % % NN cord-010119-t1x9gknd 237 41 . . . cord-010119-t1x9gknd 238 1 Male male JJ cord-010119-t1x9gknd 238 2 donors donor NNS cord-010119-t1x9gknd 238 3 showed show VBD cord-010119-t1x9gknd 238 4 higher high JJR cord-010119-t1x9gknd 238 5 SO so RB cord-010119-t1x9gknd 238 6 2 2 CD cord-010119-t1x9gknd 238 7 compared compare VBN cord-010119-t1x9gknd 238 8 to to IN cord-010119-t1x9gknd 238 9 female female JJ cord-010119-t1x9gknd 238 10 donors donor NNS cord-010119-t1x9gknd 238 11 ( ( -LRB- cord-010119-t1x9gknd 238 12 p<0.04 p<0.04 NN cord-010119-t1x9gknd 238 13 ) ) -RRB- cord-010119-t1x9gknd 238 14 . . . cord-010119-t1x9gknd 239 1 No no DT cord-010119-t1x9gknd 239 2 correlations correlation NNS cord-010119-t1x9gknd 239 3 were be VBD cord-010119-t1x9gknd 239 4 observed observe VBN cord-010119-t1x9gknd 239 5 between between IN cord-010119-t1x9gknd 239 6 SO so RB cord-010119-t1x9gknd 239 7 2 2 CD cord-010119-t1x9gknd 239 8 levels level NNS cord-010119-t1x9gknd 239 9 and and CC cord-010119-t1x9gknd 239 10 processing processing NN cord-010119-t1x9gknd 239 11 time time NN cord-010119-t1x9gknd 239 12 , , , cord-010119-t1x9gknd 239 13 donor donor NN cord-010119-t1x9gknd 239 14 age age NN cord-010119-t1x9gknd 239 15 or or CC cord-010119-t1x9gknd 239 16 blood blood NN cord-010119-t1x9gknd 239 17 types type NNS cord-010119-t1x9gknd 239 18 . . . cord-010119-t1x9gknd 240 1 Metabolomics Metabolomics NNP cord-010119-t1x9gknd 240 2 workflow workflow NN cord-010119-t1x9gknd 240 3 indicated indicate VBD cord-010119-t1x9gknd 240 4 that that IN cord-010119-t1x9gknd 240 5 lower low JJR cord-010119-t1x9gknd 240 6 SO so RB cord-010119-t1x9gknd 240 7 2 2 CD cord-010119-t1x9gknd 240 8 levels level NNS cord-010119-t1x9gknd 240 9 ameliorate ameliorate VBP cord-010119-t1x9gknd 240 10 the the DT cord-010119-t1x9gknd 240 11 energy energy NN cord-010119-t1x9gknd 240 12 and and CC cord-010119-t1x9gknd 240 13 oxidative oxidative JJ cord-010119-t1x9gknd 240 14 metabolic metabolic JJ cord-010119-t1x9gknd 240 15 lesion lesion NN cord-010119-t1x9gknd 240 16 . . . cord-010119-t1x9gknd 241 1 Lower low JJR cord-010119-t1x9gknd 241 2 SO so RB cord-010119-t1x9gknd 241 3 2 2 CD cord-010119-t1x9gknd 241 4 levels level NNS cord-010119-t1x9gknd 241 5 yielded yield VBD cord-010119-t1x9gknd 241 6 higher high JJR cord-010119-t1x9gknd 241 7 rate rate NN cord-010119-t1x9gknd 241 8 of of IN cord-010119-t1x9gknd 241 9 GSH GSH NNP cord-010119-t1x9gknd 241 10 synthesis synthesis NN cord-010119-t1x9gknd 241 11 , , , cord-010119-t1x9gknd 241 12 higher high JJR cord-010119-t1x9gknd 241 13 NADPH NADPH NNP cord-010119-t1x9gknd 241 14 concentration concentration NN cord-010119-t1x9gknd 241 15 , , , cord-010119-t1x9gknd 241 16 higher high JJR cord-010119-t1x9gknd 241 17 GSH GSH NNP cord-010119-t1x9gknd 241 18 / / SYM cord-010119-t1x9gknd 241 19 GSSG GSSG NNP cord-010119-t1x9gknd 241 20 and and CC cord-010119-t1x9gknd 241 21 NADPH NADPH NNP cord-010119-t1x9gknd 241 22 / / SYM cord-010119-t1x9gknd 241 23 NADP NADP NNP cord-010119-t1x9gknd 241 24 1 1 CD cord-010119-t1x9gknd 241 25 ratios ratio NNS cord-010119-t1x9gknd 241 26 , , , cord-010119-t1x9gknd 241 27 lower lower VB cord-010119-t1x9gknd 241 28 supernatant supernatant JJ cord-010119-t1x9gknd 241 29 urate urate NN cord-010119-t1x9gknd 241 30 consumption consumption NN cord-010119-t1x9gknd 241 31 and and CC cord-010119-t1x9gknd 241 32 lower low JJR cord-010119-t1x9gknd 241 33 purine purine NN cord-010119-t1x9gknd 241 34 oxidation oxidation NN cord-010119-t1x9gknd 241 35 . . . cord-010119-t1x9gknd 242 1 The the DT cord-010119-t1x9gknd 242 2 surprisingly surprisingly RB cord-010119-t1x9gknd 242 3 wide wide JJ cord-010119-t1x9gknd 242 4 distribution distribution NN cord-010119-t1x9gknd 242 5 of of IN cord-010119-t1x9gknd 242 6 starting start VBG cord-010119-t1x9gknd 242 7 % % NN cord-010119-t1x9gknd 242 8 SO so RB cord-010119-t1x9gknd 242 9 2 2 CD cord-010119-t1x9gknd 242 10 levels level NNS cord-010119-t1x9gknd 242 11 was be VBD cord-010119-t1x9gknd 242 12 observed observe VBN cord-010119-t1x9gknd 242 13 from from IN cord-010119-t1x9gknd 242 14 LR LR NNP cord-010119-t1x9gknd 242 15 - - HYPH cord-010119-t1x9gknd 242 16 RCC RCC NNP cord-010119-t1x9gknd 242 17 manufactured manufacture VBD cord-010119-t1x9gknd 242 18 at at IN cord-010119-t1x9gknd 242 19 a a DT cord-010119-t1x9gknd 242 20 blood blood NN cord-010119-t1x9gknd 242 21 center center NN cord-010119-t1x9gknd 242 22 using use VBG cord-010119-t1x9gknd 242 23 8-hour 8-hour CD cord-010119-t1x9gknd 242 24 room room NN cord-010119-t1x9gknd 242 25 Background background NN cord-010119-t1x9gknd 242 26 / / SYM cord-010119-t1x9gknd 242 27 Case Case NNP cord-010119-t1x9gknd 242 28 Studies Studies NNPS cord-010119-t1x9gknd 242 29 : : : cord-010119-t1x9gknd 242 30 Cellular cellular JJ cord-010119-t1x9gknd 242 31 prion prion NN cord-010119-t1x9gknd 242 32 protein protein NN cord-010119-t1x9gknd 242 33 ( ( -LRB- cord-010119-t1x9gknd 242 34 PrP PrP NNP cord-010119-t1x9gknd 242 35 C C NNP cord-010119-t1x9gknd 242 36 ) ) -RRB- cord-010119-t1x9gknd 242 37 is be VBZ cord-010119-t1x9gknd 242 38 a a DT cord-010119-t1x9gknd 242 39 GPI GPI NNP cord-010119-t1x9gknd 242 40 - - HYPH cord-010119-t1x9gknd 242 41 anchored anchor VBN cord-010119-t1x9gknd 242 42 cell cell NN cord-010119-t1x9gknd 242 43 surface surface NN cord-010119-t1x9gknd 242 44 glycoprotein glycoprotein NN cord-010119-t1x9gknd 242 45 that that WDT cord-010119-t1x9gknd 242 46 is be VBZ cord-010119-t1x9gknd 242 47 expressed express VBN cord-010119-t1x9gknd 242 48 mainly mainly RB cord-010119-t1x9gknd 242 49 in in IN cord-010119-t1x9gknd 242 50 the the DT cord-010119-t1x9gknd 242 51 brain brain NN cord-010119-t1x9gknd 242 52 but but CC cord-010119-t1x9gknd 242 53 also also RB cord-010119-t1x9gknd 242 54 in in IN cord-010119-t1x9gknd 242 55 peripheral peripheral JJ cord-010119-t1x9gknd 242 56 organs organ NNS cord-010119-t1x9gknd 242 57 including include VBG cord-010119-t1x9gknd 242 58 blood blood NN cord-010119-t1x9gknd 242 59 , , , cord-010119-t1x9gknd 242 60 bone bone NN cord-010119-t1x9gknd 242 61 marrow marrow NN cord-010119-t1x9gknd 242 62 ( ( -LRB- cord-010119-t1x9gknd 242 63 BM BM NNP cord-010119-t1x9gknd 242 64 ) ) -RRB- cord-010119-t1x9gknd 242 65 , , , cord-010119-t1x9gknd 242 66 and and CC cord-010119-t1x9gknd 242 67 lymphoid lymphoid JJ cord-010119-t1x9gknd 242 68 tissue tissue NN cord-010119-t1x9gknd 242 69 . . . cord-010119-t1x9gknd 243 1 PrP PrP NNP cord-010119-t1x9gknd 243 2 C C NNP cord-010119-t1x9gknd 243 3 can can MD cord-010119-t1x9gknd 243 4 be be VB cord-010119-t1x9gknd 243 5 converted convert VBN cord-010119-t1x9gknd 243 6 post post NN cord-010119-t1x9gknd 243 7 - - NN cord-010119-t1x9gknd 243 8 translationally translationally RB cord-010119-t1x9gknd 243 9 into into IN cord-010119-t1x9gknd 243 10 scrapie scrapie NN cord-010119-t1x9gknd 243 11 - - HYPH cord-010119-t1x9gknd 243 12 PrP prp NN cord-010119-t1x9gknd 243 13 ( ( -LRB- cord-010119-t1x9gknd 243 14 PrP PrP NNP cord-010119-t1x9gknd 243 15 Sc Sc NNP cord-010119-t1x9gknd 243 16 ) ) -RRB- cord-010119-t1x9gknd 243 17 , , , cord-010119-t1x9gknd 243 18 which which WDT cord-010119-t1x9gknd 243 19 is be VBZ cord-010119-t1x9gknd 243 20 involved involve VBN cord-010119-t1x9gknd 243 21 in in IN cord-010119-t1x9gknd 243 22 the the DT cord-010119-t1x9gknd 243 23 pathogenesis pathogenesis NN cord-010119-t1x9gknd 243 24 of of IN cord-010119-t1x9gknd 243 25 neurodegenerative neurodegenerative JJ cord-010119-t1x9gknd 243 26 diseases disease NNS cord-010119-t1x9gknd 243 27 including include VBG cord-010119-t1x9gknd 243 28 Creutzfeldt Creutzfeldt NNP cord-010119-t1x9gknd 243 29 - - HYPH cord-010119-t1x9gknd 243 30 Jakob Jakob NNP cord-010119-t1x9gknd 243 31 disease disease NN cord-010119-t1x9gknd 243 32 , , , cord-010119-t1x9gknd 243 33 kuru kuru NN cord-010119-t1x9gknd 243 34 in in IN cord-010119-t1x9gknd 243 35 humans human NNS cord-010119-t1x9gknd 243 36 , , , cord-010119-t1x9gknd 243 37 and and CC cord-010119-t1x9gknd 243 38 scrapie scrapie NN cord-010119-t1x9gknd 243 39 and and CC cord-010119-t1x9gknd 243 40 bovine bovine JJ cord-010119-t1x9gknd 243 41 spongiform spongiform JJ cord-010119-t1x9gknd 243 42 encephalopathy encephalopathy NN cord-010119-t1x9gknd 243 43 in in IN cord-010119-t1x9gknd 243 44 animals animal NNS cord-010119-t1x9gknd 243 45 . . . cord-010119-t1x9gknd 244 1 However however RB cord-010119-t1x9gknd 244 2 , , , cord-010119-t1x9gknd 244 3 biological biological JJ cord-010119-t1x9gknd 244 4 functions function NNS cord-010119-t1x9gknd 244 5 of of IN cord-010119-t1x9gknd 244 6 PrP prp NN cord-010119-t1x9gknd 244 7 C C NNP cord-010119-t1x9gknd 244 8 have have VBP cord-010119-t1x9gknd 244 9 yet yet RB cord-010119-t1x9gknd 244 10 to to TO cord-010119-t1x9gknd 244 11 be be VB cord-010119-t1x9gknd 244 12 conclusively conclusively RB cord-010119-t1x9gknd 244 13 elucidated elucidate VBN cord-010119-t1x9gknd 244 14 . . . cord-010119-t1x9gknd 245 1 Study Study NNP cord-010119-t1x9gknd 245 2 Design Design NNP cord-010119-t1x9gknd 245 3 / / SYM cord-010119-t1x9gknd 245 4 Method method NN cord-010119-t1x9gknd 245 5 : : : cord-010119-t1x9gknd 245 6 In in IN cord-010119-t1x9gknd 245 7 this this DT cord-010119-t1x9gknd 245 8 study study NN cord-010119-t1x9gknd 245 9 , , , cord-010119-t1x9gknd 245 10 PrP prp NN cord-010119-t1x9gknd 245 11 C c NN cord-010119-t1x9gknd 245 12 knockout knockout NN cord-010119-t1x9gknd 245 13 mice mouse NNS cord-010119-t1x9gknd 245 14 ( ( -LRB- cord-010119-t1x9gknd 245 15 KO KO NNP cord-010119-t1x9gknd 245 16 ) ) -RRB- cord-010119-t1x9gknd 245 17 are be VBP cord-010119-t1x9gknd 245 18 utilized utilize VBN cord-010119-t1x9gknd 245 19 to to TO cord-010119-t1x9gknd 245 20 investigate investigate VB cord-010119-t1x9gknd 245 21 the the DT cord-010119-t1x9gknd 245 22 role role NN cord-010119-t1x9gknd 245 23 of of IN cord-010119-t1x9gknd 245 24 PrP prp NN cord-010119-t1x9gknd 245 25 C C NNP cord-010119-t1x9gknd 245 26 in in IN cord-010119-t1x9gknd 245 27 the the DT cord-010119-t1x9gknd 245 28 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 245 29 system system NN cord-010119-t1x9gknd 245 30 with with IN cord-010119-t1x9gknd 245 31 controls control NNS cord-010119-t1x9gknd 245 32 of of IN cord-010119-t1x9gknd 245 33 age age NN cord-010119-t1x9gknd 245 34 and and CC cord-010119-t1x9gknd 245 35 sex sex NN cord-010119-t1x9gknd 245 36 - - HYPH cord-010119-t1x9gknd 245 37 matched match VBN cord-010119-t1x9gknd 245 38 PrP prp NN cord-010119-t1x9gknd 245 39 C c NN cord-010119-t1x9gknd 245 40 transgenic transgenic JJ cord-010119-t1x9gknd 245 41 mice mouse NNS cord-010119-t1x9gknd 245 42 harboring harbor VBG cord-010119-t1x9gknd 245 43 a a DT cord-010119-t1x9gknd 245 44 slightly slightly RB cord-010119-t1x9gknd 245 45 augmented augment VBN cord-010119-t1x9gknd 245 46 PrP prp NN cord-010119-t1x9gknd 245 47 C c NN cord-010119-t1x9gknd 245 48 expression expression NN cord-010119-t1x9gknd 245 49 . . . cord-010119-t1x9gknd 246 1 Peripheral peripheral JJ cord-010119-t1x9gknd 246 2 blood blood NN cord-010119-t1x9gknd 246 3 was be VBD cord-010119-t1x9gknd 246 4 examined examine VBN cord-010119-t1x9gknd 246 5 by by IN cord-010119-t1x9gknd 246 6 hematology hematology NN cord-010119-t1x9gknd 246 7 analyzer analyzer NN cord-010119-t1x9gknd 246 8 to to TO cord-010119-t1x9gknd 246 9 establish establish VB cord-010119-t1x9gknd 246 10 counts count NNS cord-010119-t1x9gknd 246 11 . . . cord-010119-t1x9gknd 247 1 Bone bone NN cord-010119-t1x9gknd 247 2 marrow marrow NN cord-010119-t1x9gknd 247 3 , , , cord-010119-t1x9gknd 247 4 thymus thymus NN cord-010119-t1x9gknd 247 5 , , , cord-010119-t1x9gknd 247 6 spleen spleen NNS cord-010119-t1x9gknd 247 7 , , , cord-010119-t1x9gknd 247 8 lymph lymph NN cord-010119-t1x9gknd 247 9 nodes node NNS cord-010119-t1x9gknd 247 10 , , , cord-010119-t1x9gknd 247 11 and and CC cord-010119-t1x9gknd 247 12 peripheral peripheral JJ cord-010119-t1x9gknd 247 13 blood blood NN cord-010119-t1x9gknd 247 14 were be VBD cord-010119-t1x9gknd 247 15 harvested harvest VBN cord-010119-t1x9gknd 247 16 and and CC cord-010119-t1x9gknd 247 17 analyzed analyze VBN cord-010119-t1x9gknd 247 18 by by IN cord-010119-t1x9gknd 247 19 flow flow NN cord-010119-t1x9gknd 247 20 cytometry cytometry NN cord-010119-t1x9gknd 247 21 using use VBG cord-010119-t1x9gknd 247 22 a a DT cord-010119-t1x9gknd 247 23 comprehensive comprehensive JJ cord-010119-t1x9gknd 247 24 panel panel NN cord-010119-t1x9gknd 247 25 of of IN cord-010119-t1x9gknd 247 26 fluorochrome fluorochrome RB cord-010119-t1x9gknd 247 27 - - HYPH cord-010119-t1x9gknd 247 28 conjugated conjugate VBN cord-010119-t1x9gknd 247 29 antibodies antibody NNS cord-010119-t1x9gknd 247 30 specific specific JJ cord-010119-t1x9gknd 247 31 for for IN cord-010119-t1x9gknd 247 32 all all DT cord-010119-t1x9gknd 247 33 hematologic hematologic JJ cord-010119-t1x9gknd 247 34 cell cell NN cord-010119-t1x9gknd 247 35 precursors/ precursors/ CD cord-010119-t1x9gknd 247 36 lineages lineage NNS cord-010119-t1x9gknd 247 37 . . . cord-010119-t1x9gknd 248 1 Histology histology NN cord-010119-t1x9gknd 248 2 of of IN cord-010119-t1x9gknd 248 3 bone bone NN cord-010119-t1x9gknd 248 4 marrow marrow NN cord-010119-t1x9gknd 248 5 , , , cord-010119-t1x9gknd 248 6 spleen spleen NN cord-010119-t1x9gknd 248 7 , , , cord-010119-t1x9gknd 248 8 thymus thymus NN cord-010119-t1x9gknd 248 9 and and CC cord-010119-t1x9gknd 248 10 lymph lymph NN cord-010119-t1x9gknd 248 11 nodes node NNS cord-010119-t1x9gknd 248 12 were be VBD cord-010119-t1x9gknd 248 13 evaluated evaluate VBN cord-010119-t1x9gknd 248 14 by by IN cord-010119-t1x9gknd 248 15 light light JJ cord-010119-t1x9gknd 248 16 microscopy microscopy NNS cord-010119-t1x9gknd 248 17 . . . cord-010119-t1x9gknd 249 1 Results result NNS cord-010119-t1x9gknd 250 1 /Finding /finde VBG cord-010119-t1x9gknd 250 2 : : : cord-010119-t1x9gknd 250 3 Complete complete VB cord-010119-t1x9gknd 250 4 blood blood NN cord-010119-t1x9gknd 250 5 count count NN cord-010119-t1x9gknd 250 6 ( ( -LRB- cord-010119-t1x9gknd 250 7 CBC CBC NNP cord-010119-t1x9gknd 250 8 ) ) -RRB- cord-010119-t1x9gknd 250 9 showed show VBD cord-010119-t1x9gknd 250 10 a a DT cord-010119-t1x9gknd 250 11 significant significant JJ cord-010119-t1x9gknd 250 12 increase increase NN cord-010119-t1x9gknd 250 13 of of IN cord-010119-t1x9gknd 250 14 WBC WBC NNP cord-010119-t1x9gknd 250 15 in in IN cord-010119-t1x9gknd 250 16 KO KO NNP cord-010119-t1x9gknd 250 17 mice mouse NNS cord-010119-t1x9gknd 250 18 . . . cord-010119-t1x9gknd 251 1 Closer close JJR cord-010119-t1x9gknd 251 2 analysis analysis NN cord-010119-t1x9gknd 251 3 of of IN cord-010119-t1x9gknd 251 4 WBC WBC NNP cord-010119-t1x9gknd 251 5 differential differential NN cord-010119-t1x9gknd 251 6 revealed reveal VBD cord-010119-t1x9gknd 251 7 that that IN cord-010119-t1x9gknd 251 8 the the DT cord-010119-t1x9gknd 251 9 elevated elevated JJ cord-010119-t1x9gknd 251 10 number number NN cord-010119-t1x9gknd 251 11 of of IN cord-010119-t1x9gknd 251 12 WBC WBC NNP cord-010119-t1x9gknd 251 13 in in IN cord-010119-t1x9gknd 251 14 KO KO NNP cord-010119-t1x9gknd 251 15 mice mouse NNS cord-010119-t1x9gknd 251 16 was be VBD cord-010119-t1x9gknd 251 17 due due JJ cord-010119-t1x9gknd 251 18 to to IN cord-010119-t1x9gknd 251 19 lymphocytosis lymphocytosis NNP cord-010119-t1x9gknd 251 20 . . . cord-010119-t1x9gknd 252 1 Specifically specifically RB cord-010119-t1x9gknd 252 2 , , , cord-010119-t1x9gknd 252 3 KO KO NNP cord-010119-t1x9gknd 252 4 mice mouse NNS cord-010119-t1x9gknd 252 5 had have VBD cord-010119-t1x9gknd 252 6 a a DT cord-010119-t1x9gknd 252 7 3-fold 3-fold CD cord-010119-t1x9gknd 252 8 increase increase NN cord-010119-t1x9gknd 252 9 in in IN cord-010119-t1x9gknd 252 10 the the DT cord-010119-t1x9gknd 252 11 absolute absolute JJ cord-010119-t1x9gknd 252 12 lymphocyte lymphocyte NN cord-010119-t1x9gknd 252 13 count count NN cord-010119-t1x9gknd 252 14 ( ( -LRB- cord-010119-t1x9gknd 252 15 KO KO NNP cord-010119-t1x9gknd 252 16 7.59 7.59 CD cord-010119-t1x9gknd 252 17 6 6 CD cord-010119-t1x9gknd 252 18 4.63 4.63 CD cord-010119-t1x9gknd 252 19 x10 x10 CD cord-010119-t1x9gknd 252 20 9 9 CD cord-010119-t1x9gknd 252 21 /L /L . cord-010119-t1x9gknd 252 22 vs. vs. CC cord-010119-t1x9gknd 252 23 WT WT NNP cord-010119-t1x9gknd 252 24 2.90 2.90 CD cord-010119-t1x9gknd 252 25 6 6 CD cord-010119-t1x9gknd 252 26 1.32 1.32 CD cord-010119-t1x9gknd 252 27 x10 x10 CD cord-010119-t1x9gknd 252 28 9 9 CD cord-010119-t1x9gknd 252 29 /L /l NN cord-010119-t1x9gknd 252 30 , , , cord-010119-t1x9gknd 252 31 p p NN cord-010119-t1x9gknd 252 32 5 5 CD cord-010119-t1x9gknd 252 33 0.0303 0.0303 CD cord-010119-t1x9gknd 252 34 ) ) -RRB- cord-010119-t1x9gknd 252 35 , , , cord-010119-t1x9gknd 252 36 as as RB cord-010119-t1x9gknd 252 37 well well RB cord-010119-t1x9gknd 252 38 as as IN cord-010119-t1x9gknd 252 39 a a DT cord-010119-t1x9gknd 252 40 higher high JJR cord-010119-t1x9gknd 252 41 lymphocyte lymphocyte NN cord-010119-t1x9gknd 252 42 percentage percentage NN cord-010119-t1x9gknd 252 43 compared compare VBN cord-010119-t1x9gknd 252 44 to to IN cord-010119-t1x9gknd 252 45 controls control NNS cord-010119-t1x9gknd 252 46 . . . cord-010119-t1x9gknd 253 1 KO KO NNP cord-010119-t1x9gknd 253 2 mice mouse NNS cord-010119-t1x9gknd 253 3 also also RB cord-010119-t1x9gknd 253 4 had have VBD cord-010119-t1x9gknd 253 5 a a DT cord-010119-t1x9gknd 253 6 trend trend NN cord-010119-t1x9gknd 253 7 toward toward IN cord-010119-t1x9gknd 253 8 higher high JJR cord-010119-t1x9gknd 253 9 hemoglobin hemoglobin NN cord-010119-t1x9gknd 253 10 , , , cord-010119-t1x9gknd 253 11 RBC RBC NNP cord-010119-t1x9gknd 253 12 , , , cord-010119-t1x9gknd 253 13 and and CC cord-010119-t1x9gknd 253 14 hematocrit hematocrit NN cord-010119-t1x9gknd 253 15 compared compare VBN cord-010119-t1x9gknd 253 16 to to IN cord-010119-t1x9gknd 253 17 WT WT NNP cord-010119-t1x9gknd 253 18 mice mouse NNS cord-010119-t1x9gknd 253 19 . . . cord-010119-t1x9gknd 254 1 Additionally additionally RB cord-010119-t1x9gknd 254 2 , , , cord-010119-t1x9gknd 254 3 platelet platelet NN cord-010119-t1x9gknd 254 4 count count NN cord-010119-t1x9gknd 254 5 in in IN cord-010119-t1x9gknd 254 6 KO KO NNP cord-010119-t1x9gknd 254 7 mice mouse NNS cord-010119-t1x9gknd 254 8 was be VBD cord-010119-t1x9gknd 254 9 higher high JJR cord-010119-t1x9gknd 254 10 than than IN cord-010119-t1x9gknd 254 11 control control NN cord-010119-t1x9gknd 254 12 mice mouse NNS cord-010119-t1x9gknd 254 13 . . . cord-010119-t1x9gknd 255 1 Of of IN cord-010119-t1x9gknd 255 2 interest interest NN cord-010119-t1x9gknd 255 3 , , , cord-010119-t1x9gknd 255 4 the the DT cord-010119-t1x9gknd 255 5 mean mean JJ cord-010119-t1x9gknd 255 6 platelet platelet NN cord-010119-t1x9gknd 255 7 volume volume NN cord-010119-t1x9gknd 255 8 indicating indicate VBG cord-010119-t1x9gknd 255 9 platelet platelet NN cord-010119-t1x9gknd 255 10 size size NN cord-010119-t1x9gknd 255 11 was be VBD cord-010119-t1x9gknd 255 12 significantly significantly RB cord-010119-t1x9gknd 255 13 increased increase VBN cord-010119-t1x9gknd 255 14 in in IN cord-010119-t1x9gknd 255 15 KO KO NNP cord-010119-t1x9gknd 255 16 mice mouse NNS cord-010119-t1x9gknd 255 17 compared compare VBN cord-010119-t1x9gknd 255 18 to to IN cord-010119-t1x9gknd 255 19 controls control NNS cord-010119-t1x9gknd 255 20 ( ( -LRB- cord-010119-t1x9gknd 255 21 KO KO NNP cord-010119-t1x9gknd 255 22 6.00 6.00 CD cord-010119-t1x9gknd 255 23 6 6 CD cord-010119-t1x9gknd 255 24 0.29 0.29 CD cord-010119-t1x9gknd 255 25 fL fL NNP cord-010119-t1x9gknd 255 26 vs. vs. IN cord-010119-t1x9gknd 255 27 WT WT NNP cord-010119-t1x9gknd 255 28 5.24 5.24 CD cord-010119-t1x9gknd 255 29 6 6 CD cord-010119-t1x9gknd 255 30 0.56 0.56 CD cord-010119-t1x9gknd 255 31 fL fL NNP cord-010119-t1x9gknd 255 32 , , , cord-010119-t1x9gknd 255 33 p50.0140 p50.0140 NN cord-010119-t1x9gknd 255 34 ) ) -RRB- cord-010119-t1x9gknd 255 35 . . . cord-010119-t1x9gknd 256 1 A a DT cord-010119-t1x9gknd 256 2 comprehensive comprehensive JJ cord-010119-t1x9gknd 256 3 flow flow NN cord-010119-t1x9gknd 256 4 cytometric cytometric NN cord-010119-t1x9gknd 256 5 analysis analysis NN cord-010119-t1x9gknd 256 6 of of IN cord-010119-t1x9gknd 256 7 all all DT cord-010119-t1x9gknd 256 8 cell cell NN cord-010119-t1x9gknd 256 9 lineages lineage NNS cord-010119-t1x9gknd 256 10 revealed reveal VBD cord-010119-t1x9gknd 256 11 no no DT cord-010119-t1x9gknd 256 12 significant significant JJ cord-010119-t1x9gknd 256 13 differences difference NNS cord-010119-t1x9gknd 256 14 in in IN cord-010119-t1x9gknd 256 15 the the DT cord-010119-t1x9gknd 256 16 numbers number NNS cord-010119-t1x9gknd 256 17 of of IN cord-010119-t1x9gknd 256 18 RBC RBC NNP cord-010119-t1x9gknd 256 19 and and CC cord-010119-t1x9gknd 256 20 megakaryocyte megakaryocyte NNP cord-010119-t1x9gknd 256 21 in in IN cord-010119-t1x9gknd 256 22 BM BM NNP cord-010119-t1x9gknd 256 23 , , , cord-010119-t1x9gknd 256 24 and and CC cord-010119-t1x9gknd 256 25 of of IN cord-010119-t1x9gknd 256 26 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 256 27 in in IN cord-010119-t1x9gknd 256 28 the the DT cord-010119-t1x9gknd 256 29 thymus thymus NN cord-010119-t1x9gknd 256 30 , , , cord-010119-t1x9gknd 256 31 spleen spleen NN cord-010119-t1x9gknd 256 32 and and CC cord-010119-t1x9gknd 256 33 lymph lymph NN cord-010119-t1x9gknd 256 34 nodes node NNS cord-010119-t1x9gknd 256 35 . . . cord-010119-t1x9gknd 257 1 Histological histological JJ cord-010119-t1x9gknd 257 2 analysis analysis NN cord-010119-t1x9gknd 257 3 of of IN cord-010119-t1x9gknd 257 4 BM BM NNP cord-010119-t1x9gknd 257 5 , , , cord-010119-t1x9gknd 257 6 thymus thymus NN cord-010119-t1x9gknd 257 7 , , , cord-010119-t1x9gknd 257 8 spleen spleen NN cord-010119-t1x9gknd 257 9 and and CC cord-010119-t1x9gknd 257 10 lymph lymph NN cord-010119-t1x9gknd 257 11 node node NN cord-010119-t1x9gknd 257 12 tissue tissue NN cord-010119-t1x9gknd 257 13 from from IN cord-010119-t1x9gknd 257 14 KO KO NNP cord-010119-t1x9gknd 257 15 and and CC cord-010119-t1x9gknd 257 16 WT WT NNP cord-010119-t1x9gknd 257 17 animals animal NNS cord-010119-t1x9gknd 257 18 failed fail VBD cord-010119-t1x9gknd 257 19 to to TO cord-010119-t1x9gknd 257 20 show show VB cord-010119-t1x9gknd 257 21 morphological morphological JJ cord-010119-t1x9gknd 257 22 differences difference NNS cord-010119-t1x9gknd 257 23 between between IN cord-010119-t1x9gknd 257 24 the the DT cord-010119-t1x9gknd 257 25 two two CD cord-010119-t1x9gknd 257 26 groups group NNS cord-010119-t1x9gknd 257 27 . . . cord-010119-t1x9gknd 258 1 Conclusion conclusion NN cord-010119-t1x9gknd 258 2 : : : cord-010119-t1x9gknd 259 1 Absence absence NN cord-010119-t1x9gknd 259 2 of of IN cord-010119-t1x9gknd 259 3 PrP prp NN cord-010119-t1x9gknd 259 4 C C NNP cord-010119-t1x9gknd 259 5 resulted result VBD cord-010119-t1x9gknd 259 6 in in IN cord-010119-t1x9gknd 259 7 significant significant JJ cord-010119-t1x9gknd 259 8 leukocytosis leukocytosis NN cord-010119-t1x9gknd 259 9 and and CC cord-010119-t1x9gknd 259 10 specifically specifically RB cord-010119-t1x9gknd 259 11 higher high JJR cord-010119-t1x9gknd 259 12 absolute absolute JJ cord-010119-t1x9gknd 259 13 count count NN cord-010119-t1x9gknd 259 14 and and CC cord-010119-t1x9gknd 259 15 percentage percentage NN cord-010119-t1x9gknd 259 16 of of IN cord-010119-t1x9gknd 259 17 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 259 18 , , , cord-010119-t1x9gknd 259 19 as as RB cord-010119-t1x9gknd 259 20 well well RB cord-010119-t1x9gknd 259 21 as as IN cord-010119-t1x9gknd 259 22 larger large JJR cord-010119-t1x9gknd 259 23 platelets platelet NNS cord-010119-t1x9gknd 259 24 in in IN cord-010119-t1x9gknd 259 25 peripheral peripheral JJ cord-010119-t1x9gknd 259 26 blood blood NN cord-010119-t1x9gknd 259 27 , , , cord-010119-t1x9gknd 259 28 but but CC cord-010119-t1x9gknd 259 29 does do VBZ cord-010119-t1x9gknd 259 30 not not RB cord-010119-t1x9gknd 259 31 appear appear VB cord-010119-t1x9gknd 259 32 to to TO cord-010119-t1x9gknd 259 33 affect affect VB cord-010119-t1x9gknd 259 34 hematopoiesis hematopoiesis NN cord-010119-t1x9gknd 259 35 and and CC cord-010119-t1x9gknd 259 36 lymphopoiesis lymphopoiesis NNP cord-010119-t1x9gknd 259 37 . . . cord-010119-t1x9gknd 260 1 Our -PRON- PRP$ cord-010119-t1x9gknd 260 2 findings finding NNS cord-010119-t1x9gknd 260 3 indicate indicate VBP cord-010119-t1x9gknd 260 4 that that IN cord-010119-t1x9gknd 260 5 PrP prp NN cord-010119-t1x9gknd 260 6 C C NNP cord-010119-t1x9gknd 260 7 might may MD cord-010119-t1x9gknd 260 8 be be VB cord-010119-t1x9gknd 260 9 critical critical JJ cord-010119-t1x9gknd 260 10 in in IN cord-010119-t1x9gknd 260 11 the the DT cord-010119-t1x9gknd 260 12 survival survival NN cord-010119-t1x9gknd 260 13 and and CC cord-010119-t1x9gknd 260 14 trafficking trafficking NN cord-010119-t1x9gknd 260 15 of of IN cord-010119-t1x9gknd 260 16 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 260 17 in in IN cord-010119-t1x9gknd 260 18 peripheral peripheral JJ cord-010119-t1x9gknd 260 19 blood blood NN cord-010119-t1x9gknd 260 20 . . . cord-010119-t1x9gknd 261 1 The the DT cord-010119-t1x9gknd 261 2 molecular molecular JJ cord-010119-t1x9gknd 261 3 mechanisms mechanism NNS cord-010119-t1x9gknd 261 4 underlying underlie VBG cord-010119-t1x9gknd 261 5 the the DT cord-010119-t1x9gknd 261 6 observed observed JJ cord-010119-t1x9gknd 261 7 changes change NNS cord-010119-t1x9gknd 261 8 in in IN cord-010119-t1x9gknd 261 9 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 261 10 and and CC cord-010119-t1x9gknd 261 11 platelets platelet NNS cord-010119-t1x9gknd 261 12 , , , cord-010119-t1x9gknd 261 13 and and CC cord-010119-t1x9gknd 261 14 whether whether IN cord-010119-t1x9gknd 261 15 these these DT cord-010119-t1x9gknd 261 16 involve involve VBP cord-010119-t1x9gknd 261 17 functional functional JJ cord-010119-t1x9gknd 261 18 changes change NNS cord-010119-t1x9gknd 261 19 in in IN cord-010119-t1x9gknd 261 20 these these DT cord-010119-t1x9gknd 261 21 cells cell NNS cord-010119-t1x9gknd 261 22 will will MD cord-010119-t1x9gknd 261 23 be be VB cord-010119-t1x9gknd 261 24 subject subject JJ cord-010119-t1x9gknd 261 25 of of IN cord-010119-t1x9gknd 261 26 future future JJ cord-010119-t1x9gknd 261 27 studies study NNS cord-010119-t1x9gknd 261 28 . . . cord-010119-t1x9gknd 262 1 Potential potential JJ cord-010119-t1x9gknd 262 2 Role role NN cord-010119-t1x9gknd 262 3 of of IN cord-010119-t1x9gknd 262 4 CD81FOXP31 CD81FOXP31 NNP cord-010119-t1x9gknd 262 5 Regulatory Regulatory NNP cord-010119-t1x9gknd 262 6 T T NNP cord-010119-t1x9gknd 262 7 Cells cell NNS cord-010119-t1x9gknd 263 1 Derived Derived NNP cord-010119-t1x9gknd 263 2 Exosomes Exosomes NNPS cord-010119-t1x9gknd 263 3 in in IN cord-010119-t1x9gknd 263 4 Their -PRON- PRP$ cord-010119-t1x9gknd 263 5 Immune Immune NNP cord-010119-t1x9gknd 263 6 Modulation modulation NN cord-010119-t1x9gknd 263 7 Yiming Yiming NNP cord-010119-t1x9gknd 263 8 Yang Yang NNP cord-010119-t1x9gknd 264 1 * * NFP cord-010119-t1x9gknd 264 2 , , , cord-010119-t1x9gknd 264 3 Rufeng Rufeng NNP cord-010119-t1x9gknd 264 4 Xie Xie NNP cord-010119-t1x9gknd 264 5 and and CC cord-010119-t1x9gknd 264 6 Jie Jie NNP cord-010119-t1x9gknd 264 7 Yang Yang NNP cord-010119-t1x9gknd 264 8 . . . cord-010119-t1x9gknd 265 1 Blood Blood NNP cord-010119-t1x9gknd 265 2 Engineering Engineering NNP cord-010119-t1x9gknd 265 3 Laboratory Laboratory NNP cord-010119-t1x9gknd 265 4 , , , cord-010119-t1x9gknd 265 5 Shanghai Shanghai NNP cord-010119-t1x9gknd 265 6 Blood Blood NNP cord-010119-t1x9gknd 265 7 Center Center NNP cord-010119-t1x9gknd 265 8 Background Background NNP cord-010119-t1x9gknd 265 9 / / SYM cord-010119-t1x9gknd 265 10 Case Case NNP cord-010119-t1x9gknd 265 11 Studies Studies NNPS cord-010119-t1x9gknd 265 12 : : : cord-010119-t1x9gknd 266 1 Exosomes Exosomes NNP cord-010119-t1x9gknd 266 2 are be VBP cord-010119-t1x9gknd 266 3 defined define VBN cord-010119-t1x9gknd 266 4 as as IN cord-010119-t1x9gknd 266 5 one one CD cord-010119-t1x9gknd 266 6 type type NN cord-010119-t1x9gknd 266 7 of of IN cord-010119-t1x9gknd 266 8 membrane membrane NN cord-010119-t1x9gknd 266 9 vesicles vesicle NNS cord-010119-t1x9gknd 266 10 secreted secrete VBN cord-010119-t1x9gknd 266 11 into into IN cord-010119-t1x9gknd 266 12 extracellular extracellular JJ cord-010119-t1x9gknd 266 13 space space NN cord-010119-t1x9gknd 266 14 by by IN cord-010119-t1x9gknd 266 15 most most JJS cord-010119-t1x9gknd 266 16 types type NNS cord-010119-t1x9gknd 266 17 of of IN cord-010119-t1x9gknd 266 18 cells cell NNS cord-010119-t1x9gknd 266 19 and and CC cord-010119-t1x9gknd 266 20 are be VBP cord-010119-t1x9gknd 266 21 reported report VBN cord-010119-t1x9gknd 266 22 to to TO cord-010119-t1x9gknd 266 23 involve involve VB cord-010119-t1x9gknd 266 24 in in IN cord-010119-t1x9gknd 266 25 intercellular intercellular JJ cord-010119-t1x9gknd 266 26 communications communication NNS cord-010119-t1x9gknd 266 27 , , , cord-010119-t1x9gknd 266 28 mediate mediate VB cord-010119-t1x9gknd 266 29 biological biological JJ cord-010119-t1x9gknd 266 30 process process NN cord-010119-t1x9gknd 266 31 . . . cord-010119-t1x9gknd 267 1 Human human JJ cord-010119-t1x9gknd 267 2 periphery periphery JJ cord-010119-t1x9gknd 267 3 blood blood NN cord-010119-t1x9gknd 268 1 CD8 CD8 NNP cord-010119-t1x9gknd 268 2 1 1 CD cord-010119-t1x9gknd 268 3 FOXP3 foxp3 NN cord-010119-t1x9gknd 268 4 1 1 CD cord-010119-t1x9gknd 268 5 Tregs Tregs NNP cord-010119-t1x9gknd 268 6 cells cell NNS cord-010119-t1x9gknd 268 7 are be VBP cord-010119-t1x9gknd 268 8 reported report VBN cord-010119-t1x9gknd 268 9 as as IN cord-010119-t1x9gknd 268 10 more more RBR cord-010119-t1x9gknd 268 11 stable stable JJ cord-010119-t1x9gknd 268 12 regulatory regulatory JJ cord-010119-t1x9gknd 268 13 cells cell NNS cord-010119-t1x9gknd 268 14 with with IN cord-010119-t1x9gknd 268 15 greater great JJR cord-010119-t1x9gknd 268 16 inhibition inhibition NN cord-010119-t1x9gknd 268 17 effects effect NNS cord-010119-t1x9gknd 268 18 . . . cord-010119-t1x9gknd 269 1 However however RB cord-010119-t1x9gknd 269 2 , , , cord-010119-t1x9gknd 269 3 CD8 CD8 NNP cord-010119-t1x9gknd 269 4 1 1 CD cord-010119-t1x9gknd 269 5 FOXP3 foxp3 NN cord-010119-t1x9gknd 269 6 1 1 CD cord-010119-t1x9gknd 269 7 Tregs Tregs NNP cord-010119-t1x9gknd 269 8 derived derive VBD cord-010119-t1x9gknd 269 9 exosomes exosome NNS cord-010119-t1x9gknd 269 10 and and CC cord-010119-t1x9gknd 269 11 their -PRON- PRP$ cord-010119-t1x9gknd 269 12 functions function NNS cord-010119-t1x9gknd 269 13 involved involve VBN cord-010119-t1x9gknd 269 14 in in IN cord-010119-t1x9gknd 269 15 CD8 CD8 NNP cord-010119-t1x9gknd 269 16 1 1 CD cord-010119-t1x9gknd 269 17 Tregs Tregs NNP cord-010119-t1x9gknd 269 18 mediated mediate VBD cord-010119-t1x9gknd 269 19 immune immune JJ cord-010119-t1x9gknd 269 20 - - HYPH cord-010119-t1x9gknd 269 21 modulation modulation NN cord-010119-t1x9gknd 269 22 were be VBD cord-010119-t1x9gknd 269 23 seldom seldom RB cord-010119-t1x9gknd 269 24 reported report VBN cord-010119-t1x9gknd 269 25 . . . cord-010119-t1x9gknd 270 1 Study Study NNP cord-010119-t1x9gknd 270 2 Design Design NNP cord-010119-t1x9gknd 270 3 / / SYM cord-010119-t1x9gknd 270 4 Method method NN cord-010119-t1x9gknd 270 5 : : : cord-010119-t1x9gknd 271 1 CD8 CD8 NNP cord-010119-t1x9gknd 271 2 1 1 CD cord-010119-t1x9gknd 271 3 T T NNP cord-010119-t1x9gknd 271 4 cells cell NNS cord-010119-t1x9gknd 271 5 were be VBD cord-010119-t1x9gknd 271 6 freshly freshly RB cord-010119-t1x9gknd 271 7 purified purify VBN cord-010119-t1x9gknd 271 8 from from IN cord-010119-t1x9gknd 271 9 PBMCs pbmc NNS cord-010119-t1x9gknd 271 10 , , , cord-010119-t1x9gknd 271 11 cultured culture VBN cord-010119-t1x9gknd 271 12 with with IN cord-010119-t1x9gknd 271 13 anti anti JJ cord-010119-t1x9gknd 271 14 - - JJ cord-010119-t1x9gknd 271 15 CD3 CD3 NNP cord-010119-t1x9gknd 271 16 / / SYM cord-010119-t1x9gknd 271 17 CD28 CD28 NNP cord-010119-t1x9gknd 271 18 antibody antibody NN cord-010119-t1x9gknd 271 19 packaged package VBD cord-010119-t1x9gknd 271 20 beads bead NNS cord-010119-t1x9gknd 271 21 and and CC cord-010119-t1x9gknd 271 22 IL-2 IL-2 NNP cord-010119-t1x9gknd 271 23 , , , cord-010119-t1x9gknd 271 24 and and CC cord-010119-t1x9gknd 271 25 then then RB cord-010119-t1x9gknd 271 26 polarized polarize VBD cord-010119-t1x9gknd 271 27 with with IN cord-010119-t1x9gknd 271 28 TGF TGF NNP cord-010119-t1x9gknd 271 29 - - HYPH cord-010119-t1x9gknd 271 30 b b NN cord-010119-t1x9gknd 271 31 and and CC cord-010119-t1x9gknd 271 32 rapamycin rapamycin VBD cord-010119-t1x9gknd 271 33 into into IN cord-010119-t1x9gknd 271 34 CD8 CD8 NNP cord-010119-t1x9gknd 271 35 1 1 CD cord-010119-t1x9gknd 271 36 FOXP3 FOXP3 NNP cord-010119-t1x9gknd 271 37 1 1 CD cord-010119-t1x9gknd 271 38 Treg Treg NNP cord-010119-t1x9gknd 271 39 cells cell NNS cord-010119-t1x9gknd 271 40 . . . cord-010119-t1x9gknd 272 1 The the DT cord-010119-t1x9gknd 272 2 harvest harvest NN cord-010119-t1x9gknd 272 3 cells cell NNS cord-010119-t1x9gknd 272 4 were be VBD cord-010119-t1x9gknd 272 5 co co JJ cord-010119-t1x9gknd 272 6 - - JJ cord-010119-t1x9gknd 272 7 cultured cultured JJ cord-010119-t1x9gknd 272 8 with with IN cord-010119-t1x9gknd 272 9 CD3 CD3 NNP cord-010119-t1x9gknd 272 10 / / SYM cord-010119-t1x9gknd 272 11 CD28 CD28 NNP cord-010119-t1x9gknd 272 12 beads bead NNS cord-010119-t1x9gknd 272 13 stimulating stimulate VBG cord-010119-t1x9gknd 272 14 CD41CD25effector cd41cd25effector NN cord-010119-t1x9gknd 272 15 cells cell NNS cord-010119-t1x9gknd 272 16 in in IN cord-010119-t1x9gknd 272 17 the the DT cord-010119-t1x9gknd 272 18 transwell transwell NNP cord-010119-t1x9gknd 272 19 plate plate NN cord-010119-t1x9gknd 272 20 . . . cord-010119-t1x9gknd 273 1 The the DT cord-010119-t1x9gknd 273 2 supernatant supernatant NN cord-010119-t1x9gknd 273 3 derived derive VBN cord-010119-t1x9gknd 273 4 from from IN cord-010119-t1x9gknd 273 5 CD81 CD81 NNP cord-010119-t1x9gknd 273 6 Tregs Tregs NNP cord-010119-t1x9gknd 273 7 was be VBD cord-010119-t1x9gknd 273 8 collected collect VBN cord-010119-t1x9gknd 273 9 and and CC cord-010119-t1x9gknd 273 10 ultrafiltrated ultrafiltrate VBN cord-010119-t1x9gknd 273 11 by by IN cord-010119-t1x9gknd 273 12 centrifugation centrifugation NN cord-010119-t1x9gknd 273 13 and and CC cord-010119-t1x9gknd 273 14 the the DT cord-010119-t1x9gknd 273 15 remaining remain VBG cord-010119-t1x9gknd 273 16 solution solution NN cord-010119-t1x9gknd 273 17 was be VBD cord-010119-t1x9gknd 273 18 precipitated precipitate VBN cord-010119-t1x9gknd 273 19 with with IN cord-010119-t1x9gknd 273 20 PEG PEG NNP cord-010119-t1x9gknd 273 21 . . . cord-010119-t1x9gknd 274 1 The the DT cord-010119-t1x9gknd 274 2 harvest harvest NN cord-010119-t1x9gknd 274 3 precipitation precipitation NN cord-010119-t1x9gknd 274 4 was be VBD cord-010119-t1x9gknd 274 5 resuspended resuspend VBN cord-010119-t1x9gknd 274 6 in in IN cord-010119-t1x9gknd 274 7 PBS PBS NNP cord-010119-t1x9gknd 274 8 and and CC cord-010119-t1x9gknd 274 9 exosomes exosomes NNP cord-010119-t1x9gknd 274 10 were be VBD cord-010119-t1x9gknd 274 11 analyzed analyze VBN cord-010119-t1x9gknd 274 12 by by IN cord-010119-t1x9gknd 274 13 SEM SEM NNP cord-010119-t1x9gknd 274 14 and and CC cord-010119-t1x9gknd 274 15 NTA NTA NNP cord-010119-t1x9gknd 274 16 . . . cord-010119-t1x9gknd 275 1 Exosome exosome NN cord-010119-t1x9gknd 275 2 surface surface NN cord-010119-t1x9gknd 275 3 marker marker NN cord-010119-t1x9gknd 275 4 CD63 CD63 NNP cord-010119-t1x9gknd 275 5 , , , cord-010119-t1x9gknd 275 6 CD81 CD81 NNP cord-010119-t1x9gknd 275 7 , , , cord-010119-t1x9gknd 275 8 TSG101 TSG101 NNP cord-010119-t1x9gknd 275 9 and and CC cord-010119-t1x9gknd 275 10 other other JJ cord-010119-t1x9gknd 275 11 proteins protein NNS cord-010119-t1x9gknd 275 12 expression expression NN cord-010119-t1x9gknd 275 13 were be VBD cord-010119-t1x9gknd 275 14 evaluated evaluate VBN cord-010119-t1x9gknd 275 15 by by IN cord-010119-t1x9gknd 275 16 flow flow NN cord-010119-t1x9gknd 275 17 cytometry cytometry NN cord-010119-t1x9gknd 275 18 and and CC cord-010119-t1x9gknd 275 19 western western JJ cord-010119-t1x9gknd 275 20 blot blot NN cord-010119-t1x9gknd 275 21 . . . cord-010119-t1x9gknd 276 1 microRNA microRNA NNP cord-010119-t1x9gknd 276 2 was be VBD cord-010119-t1x9gknd 276 3 isolated isolate VBN cord-010119-t1x9gknd 276 4 with with IN cord-010119-t1x9gknd 276 5 miRcute miRcute NNP cord-010119-t1x9gknd 276 6 miRNA miRNA NNP cord-010119-t1x9gknd 276 7 kit kit NN cord-010119-t1x9gknd 276 8 and and CC cord-010119-t1x9gknd 276 9 miR-155 miR-155 NNP cord-010119-t1x9gknd 276 10 , , , cord-010119-t1x9gknd 276 11 let-7b let-7b NNP cord-010119-t1x9gknd 276 12 , , , cord-010119-t1x9gknd 276 13 let-7d let-7d NNP cord-010119-t1x9gknd 276 14 were be VBD cord-010119-t1x9gknd 276 15 measured measure VBN cord-010119-t1x9gknd 276 16 by by IN cord-010119-t1x9gknd 276 17 qPCR qPCR NNP cord-010119-t1x9gknd 276 18 . . . cord-010119-t1x9gknd 277 1 The the DT cord-010119-t1x9gknd 277 2 precipitated precipitated JJ cord-010119-t1x9gknd 277 3 exosomes exosome NNS cord-010119-t1x9gknd 277 4 were be VBD cord-010119-t1x9gknd 277 5 further further RB cord-010119-t1x9gknd 277 6 purified purify VBN cord-010119-t1x9gknd 277 7 by by IN cord-010119-t1x9gknd 277 8 CD63 CD63 NNP cord-010119-t1x9gknd 277 9 immunoaffinity immunoaffinity NN cord-010119-t1x9gknd 277 10 capture capture NN cord-010119-t1x9gknd 277 11 and and CC cord-010119-t1x9gknd 277 12 co co JJ cord-010119-t1x9gknd 277 13 - - JJ cord-010119-t1x9gknd 277 14 cultured cultured JJ cord-010119-t1x9gknd 277 15 with with IN cord-010119-t1x9gknd 277 16 effector effector NN cord-010119-t1x9gknd 277 17 cells cell NNS cord-010119-t1x9gknd 277 18 to to TO cord-010119-t1x9gknd 277 19 investigate investigate VB cord-010119-t1x9gknd 277 20 their -PRON- PRP$ cord-010119-t1x9gknd 277 21 function function NN cord-010119-t1x9gknd 277 22 in in IN cord-010119-t1x9gknd 277 23 immune immune JJ cord-010119-t1x9gknd 277 24 modulation modulation NN cord-010119-t1x9gknd 277 25 . . . cord-010119-t1x9gknd 278 1 Results result NNS cord-010119-t1x9gknd 278 2 / / SYM cord-010119-t1x9gknd 278 3 Finding finding NN cord-010119-t1x9gknd 278 4 : : : cord-010119-t1x9gknd 279 1 As as IN cord-010119-t1x9gknd 279 2 compared compare VBN cord-010119-t1x9gknd 279 3 with with IN cord-010119-t1x9gknd 279 4 direct direct JJ cord-010119-t1x9gknd 279 5 contact contact NN cord-010119-t1x9gknd 279 6 co co NN cord-010119-t1x9gknd 279 7 - - NN cord-010119-t1x9gknd 279 8 culture culture NN cord-010119-t1x9gknd 279 9 , , , cord-010119-t1x9gknd 279 10 separated separate VBD cord-010119-t1x9gknd 279 11 CD8 CD8 NNP cord-010119-t1x9gknd 279 12 1 1 CD cord-010119-t1x9gknd 279 13 Treg Treg NNP cord-010119-t1x9gknd 279 14 cells cell NNS cord-010119-t1x9gknd 279 15 could could MD cord-010119-t1x9gknd 279 16 suppress suppress VB cord-010119-t1x9gknd 279 17 the the DT cord-010119-t1x9gknd 279 18 proliferation proliferation NN cord-010119-t1x9gknd 279 19 of of IN cord-010119-t1x9gknd 279 20 effector effector JJ cord-010119-t1x9gknd 279 21 cells cell NNS cord-010119-t1x9gknd 279 22 with with IN cord-010119-t1x9gknd 279 23 a a DT cord-010119-t1x9gknd 279 24 small small JJ cord-010119-t1x9gknd 279 25 decline decline NN cord-010119-t1x9gknd 279 26 ( ( -LRB- cord-010119-t1x9gknd 279 27 p>0.05 p>0.05 NNP cord-010119-t1x9gknd 279 28 ) ) -RRB- cord-010119-t1x9gknd 279 29 , , , cord-010119-t1x9gknd 279 30 which which WDT cord-010119-t1x9gknd 279 31 means mean VBZ cord-010119-t1x9gknd 279 32 some some DT cord-010119-t1x9gknd 279 33 non non JJ cord-010119-t1x9gknd 279 34 - - JJ cord-010119-t1x9gknd 279 35 contact contact JJ cord-010119-t1x9gknd 279 36 factors factor NNS cord-010119-t1x9gknd 279 37 involved involve VBN cord-010119-t1x9gknd 279 38 in in IN cord-010119-t1x9gknd 279 39 the the DT cord-010119-t1x9gknd 279 40 CD8 CD8 NNP cord-010119-t1x9gknd 279 41 1 1 CD cord-010119-t1x9gknd 279 42 Treg Treg NNP cord-010119-t1x9gknd 279 43 mediated mediate VBD cord-010119-t1x9gknd 279 44 immune immune JJ cord-010119-t1x9gknd 279 45 modulation modulation NN cord-010119-t1x9gknd 279 46 . . . cord-010119-t1x9gknd 280 1 A a DT cord-010119-t1x9gknd 280 2 total total JJ cord-010119-t1x9gknd 280 3 number number NN cord-010119-t1x9gknd 280 4 of of IN cord-010119-t1x9gknd 280 5 4.57 4.57 CD cord-010119-t1x9gknd 280 6 6 6 CD cord-010119-t1x9gknd 280 7 0.52 0.52 CD cord-010119-t1x9gknd 280 8 3 3 CD cord-010119-t1x9gknd 280 9 10 10 CD cord-010119-t1x9gknd 280 10 8 8 CD cord-010119-t1x9gknd 281 1 /10 /10 NNP cord-010119-t1x9gknd 281 2 6 6 CD cord-010119-t1x9gknd 281 3 cells cell NNS cord-010119-t1x9gknd 281 4 exosomes exosome NNS cord-010119-t1x9gknd 281 5 were be VBD cord-010119-t1x9gknd 281 6 harvest harvest NN cord-010119-t1x9gknd 281 7 . . . cord-010119-t1x9gknd 282 1 Electron electron NN cord-010119-t1x9gknd 282 2 microscope microscope NN cord-010119-t1x9gknd 282 3 analysis analysis NN cord-010119-t1x9gknd 282 4 demonstrated demonstrate VBD cord-010119-t1x9gknd 282 5 a a DT cord-010119-t1x9gknd 282 6 kind kind NN cord-010119-t1x9gknd 282 7 of of IN cord-010119-t1x9gknd 282 8 round round NN cord-010119-t1x9gknd 282 9 - - HYPH cord-010119-t1x9gknd 282 10 shaped shape VBN cord-010119-t1x9gknd 282 11 membrane membrane NN cord-010119-t1x9gknd 282 12 vesicle vesicle NN cord-010119-t1x9gknd 282 13 50 50 CD cord-010119-t1x9gknd 282 14 - - SYM cord-010119-t1x9gknd 282 15 150 150 CD cord-010119-t1x9gknd 282 16 nm nm NN cord-010119-t1x9gknd 282 17 in in IN cord-010119-t1x9gknd 282 18 diameter diameter NN cord-010119-t1x9gknd 282 19 ( ( -LRB- cord-010119-t1x9gknd 282 20 145.16 145.16 CD cord-010119-t1x9gknd 282 21 6.7 6.7 CD cord-010119-t1x9gknd 282 22 nm nm NN cord-010119-t1x9gknd 282 23 by by IN cord-010119-t1x9gknd 282 24 NTA NTA NNP cord-010119-t1x9gknd 282 25 ) ) -RRB- cord-010119-t1x9gknd 282 26 . . . cord-010119-t1x9gknd 283 1 CD63 CD63 NNP cord-010119-t1x9gknd 283 2 and and CC cord-010119-t1x9gknd 283 3 CD81 CD81 NNP cord-010119-t1x9gknd 283 4 were be VBD cord-010119-t1x9gknd 283 5 expressed express VBN cord-010119-t1x9gknd 283 6 on on IN cord-010119-t1x9gknd 283 7 these these DT cord-010119-t1x9gknd 283 8 Background Background NNP cord-010119-t1x9gknd 283 9 / / SYM cord-010119-t1x9gknd 283 10 Case Case NNP cord-010119-t1x9gknd 283 11 Studies Studies NNPS cord-010119-t1x9gknd 283 12 : : : cord-010119-t1x9gknd 283 13 Regulatory regulatory JJ cord-010119-t1x9gknd 283 14 T t NN cord-010119-t1x9gknd 283 15 cells cell NNS cord-010119-t1x9gknd 283 16 ( ( -LRB- cord-010119-t1x9gknd 283 17 Tregs Tregs NNP cord-010119-t1x9gknd 283 18 ) ) -RRB- cord-010119-t1x9gknd 283 19 , , , cord-010119-t1x9gknd 283 20 containing contain VBG cord-010119-t1x9gknd 283 21 CD4 CD4 NNP cord-010119-t1x9gknd 283 22 1 1 CD cord-010119-t1x9gknd 283 23 and and CC cord-010119-t1x9gknd 283 24 CD8 CD8 NNP cord-010119-t1x9gknd 283 25 1 1 CD cord-010119-t1x9gknd 283 26 subtypes subtype NNS cord-010119-t1x9gknd 283 27 , , , cord-010119-t1x9gknd 283 28 play play VBP cord-010119-t1x9gknd 283 29 an an DT cord-010119-t1x9gknd 283 30 essential essential JJ cord-010119-t1x9gknd 283 31 role role NN cord-010119-t1x9gknd 283 32 in in IN cord-010119-t1x9gknd 283 33 immune immune JJ cord-010119-t1x9gknd 283 34 regulation regulation NN cord-010119-t1x9gknd 283 35 and and CC cord-010119-t1x9gknd 283 36 autoimmune autoimmune JJ cord-010119-t1x9gknd 283 37 disease disease NN cord-010119-t1x9gknd 283 38 prevention prevention NN cord-010119-t1x9gknd 283 39 which which WDT cord-010119-t1x9gknd 283 40 makes make VBZ cord-010119-t1x9gknd 283 41 it -PRON- PRP cord-010119-t1x9gknd 283 42 a a DT cord-010119-t1x9gknd 283 43 potential potential JJ cord-010119-t1x9gknd 283 44 candidate candidate NN cord-010119-t1x9gknd 283 45 for for IN cord-010119-t1x9gknd 283 46 cell cell NN cord-010119-t1x9gknd 283 47 therapy therapy NN cord-010119-t1x9gknd 283 48 on on IN cord-010119-t1x9gknd 283 49 autoimmune autoimmune JJ cord-010119-t1x9gknd 283 50 disease disease NNP cord-010119-t1x9gknd 283 51 ( ( -LRB- cord-010119-t1x9gknd 283 52 AIDs AIDs NNP cord-010119-t1x9gknd 283 53 ) ) -RRB- cord-010119-t1x9gknd 283 54 . . . cord-010119-t1x9gknd 284 1 Unfortunately unfortunately RB cord-010119-t1x9gknd 284 2 , , , cord-010119-t1x9gknd 284 3 due due IN cord-010119-t1x9gknd 284 4 to to IN cord-010119-t1x9gknd 284 5 the the DT cord-010119-t1x9gknd 284 6 instability instability NN cord-010119-t1x9gknd 284 7 of of IN cord-010119-t1x9gknd 284 8 natural natural JJ cord-010119-t1x9gknd 284 9 CD4 CD4 NNP cord-010119-t1x9gknd 284 10 1 1 CD cord-010119-t1x9gknd 284 11 Foxp3 foxp3 JJ cord-010119-t1x9gknd 284 12 1 1 CD cord-010119-t1x9gknd 284 13 regulatory regulatory JJ cord-010119-t1x9gknd 284 14 T t NN cord-010119-t1x9gknd 284 15 cells cell NNS cord-010119-t1x9gknd 284 16 ( ( -LRB- cord-010119-t1x9gknd 284 17 nTregs nTregs NNP cord-010119-t1x9gknd 284 18 ) ) -RRB- cord-010119-t1x9gknd 284 19 in in IN cord-010119-t1x9gknd 284 20 inflammation inflammation NN cord-010119-t1x9gknd 284 21 conditions condition NNS cord-010119-t1x9gknd 284 22 ( ( -LRB- cord-010119-t1x9gknd 284 23 including include VBG cord-010119-t1x9gknd 284 24 instability instability NN cord-010119-t1x9gknd 284 25 of of IN cord-010119-t1x9gknd 284 26 Foxp3 foxp3 NN cord-010119-t1x9gknd 284 27 , , , cord-010119-t1x9gknd 284 28 conversion conversion NN cord-010119-t1x9gknd 284 29 to to IN cord-010119-t1x9gknd 284 30 pro pro JJ cord-010119-t1x9gknd 284 31 - - JJ cord-010119-t1x9gknd 284 32 inflammatory inflammatory JJ cord-010119-t1x9gknd 284 33 effector effector NN cord-010119-t1x9gknd 284 34 cells cell NNS cord-010119-t1x9gknd 284 35 and and CC cord-010119-t1x9gknd 284 36 was be VBD cord-010119-t1x9gknd 284 37 unable unable JJ cord-010119-t1x9gknd 284 38 to to TO cord-010119-t1x9gknd 284 39 modify modify VB cord-010119-t1x9gknd 284 40 established establish VBN cord-010119-t1x9gknd 284 41 disease disease NN cord-010119-t1x9gknd 284 42 ) ) -RRB- cord-010119-t1x9gknd 284 43 , , , cord-010119-t1x9gknd 284 44 thus thus RB cord-010119-t1x9gknd 284 45 , , , cord-010119-t1x9gknd 284 46 it -PRON- PRP cord-010119-t1x9gknd 284 47 is be VBZ cord-010119-t1x9gknd 284 48 needed need VBN cord-010119-t1x9gknd 284 49 to to TO cord-010119-t1x9gknd 284 50 investigate investigate VB cord-010119-t1x9gknd 284 51 CD81 CD81 NNP cord-010119-t1x9gknd 284 52 regulatory regulatory JJ cord-010119-t1x9gknd 284 53 T t NN cord-010119-t1x9gknd 284 54 cells cell NNS cord-010119-t1x9gknd 284 55 stability stability NN cord-010119-t1x9gknd 284 56 both both DT cord-010119-t1x9gknd 284 57 in in IN cord-010119-t1x9gknd 284 58 vitro vitro FW cord-010119-t1x9gknd 284 59 and and CC cord-010119-t1x9gknd 284 60 in in IN cord-010119-t1x9gknd 284 61 vivo vivo NNP cord-010119-t1x9gknd 284 62 . . . cord-010119-t1x9gknd 285 1 In in IN cord-010119-t1x9gknd 285 2 our -PRON- PRP$ cord-010119-t1x9gknd 285 3 previous previous JJ cord-010119-t1x9gknd 285 4 works work NNS cord-010119-t1x9gknd 285 5 , , , cord-010119-t1x9gknd 285 6 we -PRON- PRP cord-010119-t1x9gknd 285 7 found find VBD cord-010119-t1x9gknd 285 8 that that IN cord-010119-t1x9gknd 285 9 CD8 CD8 NNP cord-010119-t1x9gknd 285 10 1 1 CD cord-010119-t1x9gknd 285 11 Treg Treg NNP cord-010119-t1x9gknd 285 12 has have VBZ cord-010119-t1x9gknd 285 13 an an DT cord-010119-t1x9gknd 285 14 effective effective JJ cord-010119-t1x9gknd 285 15 therapeutic therapeutic JJ cord-010119-t1x9gknd 285 16 function function NN cord-010119-t1x9gknd 285 17 on on IN cord-010119-t1x9gknd 285 18 CIA CIA NNP cord-010119-t1x9gknd 285 19 mice mouse NNS cord-010119-t1x9gknd 285 20 . . . cord-010119-t1x9gknd 286 1 In in IN cord-010119-t1x9gknd 286 2 this this DT cord-010119-t1x9gknd 286 3 study study NN cord-010119-t1x9gknd 286 4 we -PRON- PRP cord-010119-t1x9gknd 286 5 aim aim VBP cord-010119-t1x9gknd 286 6 to to TO cord-010119-t1x9gknd 286 7 investigate investigate VB cord-010119-t1x9gknd 286 8 the the DT cord-010119-t1x9gknd 286 9 stability stability NN cord-010119-t1x9gknd 286 10 of of IN cord-010119-t1x9gknd 286 11 induced induce VBN cord-010119-t1x9gknd 286 12 polyclonal polyclonal JJ cord-010119-t1x9gknd 286 13 human human JJ cord-010119-t1x9gknd 286 14 CD8 CD8 NNP cord-010119-t1x9gknd 286 15 1 1 CD cord-010119-t1x9gknd 286 16 regulatory regulatory JJ cord-010119-t1x9gknd 286 17 T T NNP cord-010119-t1x9gknd 286 18 cells cell NNS cord-010119-t1x9gknd 286 19 in in IN cord-010119-t1x9gknd 286 20 inflammation inflammation NN cord-010119-t1x9gknd 286 21 and and CC cord-010119-t1x9gknd 286 22 transfusion transfusion NN cord-010119-t1x9gknd 286 23 . . . cord-010119-t1x9gknd 287 1 Study Study NNP cord-010119-t1x9gknd 287 2 Design Design NNP cord-010119-t1x9gknd 287 3 / / SYM cord-010119-t1x9gknd 287 4 Method method NN cord-010119-t1x9gknd 287 5 : : : cord-010119-t1x9gknd 287 6 Human Human NNP cord-010119-t1x9gknd 287 7 CD8 CD8 NNP cord-010119-t1x9gknd 287 8 1 1 CD cord-010119-t1x9gknd 287 9 Tregs Tregs NNP cord-010119-t1x9gknd 287 10 were be VBD cord-010119-t1x9gknd 287 11 induced induce VBN cord-010119-t1x9gknd 287 12 with with IN cord-010119-t1x9gknd 287 13 TGF TGF NNP cord-010119-t1x9gknd 287 14 - - HYPH cord-010119-t1x9gknd 287 15 b1 b1 NN cord-010119-t1x9gknd 287 16 and and CC cord-010119-t1x9gknd 287 17 rapamycin rapamycin NNS cord-010119-t1x9gknd 287 18 from from IN cord-010119-t1x9gknd 287 19 CD8 CD8 NNP cord-010119-t1x9gknd 287 20 1 1 CD cord-010119-t1x9gknd 287 21 T T NNP cord-010119-t1x9gknd 287 22 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 287 23 in in IN cord-010119-t1x9gknd 287 24 vitro vitro FW cord-010119-t1x9gknd 287 25 . . . cord-010119-t1x9gknd 288 1 Collagen collagen NN cord-010119-t1x9gknd 288 2 - - HYPH cord-010119-t1x9gknd 288 3 induced induce VBN cord-010119-t1x9gknd 288 4 arthritis arthritis NN cord-010119-t1x9gknd 288 5 ( ( -LRB- cord-010119-t1x9gknd 288 6 CIA CIA NNP cord-010119-t1x9gknd 288 7 ) ) -RRB- cord-010119-t1x9gknd 289 1 mice mouse NNS cord-010119-t1x9gknd 289 2 were be VBD cord-010119-t1x9gknd 289 3 induced induce VBN cord-010119-t1x9gknd 289 4 with with IN cord-010119-t1x9gknd 289 5 type type NN cord-010119-t1x9gknd 289 6 - - HYPH cord-010119-t1x9gknd 289 7 two two CD cord-010119-t1x9gknd 289 8 collagen collagen NN cord-010119-t1x9gknd 289 9 as as IN cord-010119-t1x9gknd 289 10 an an DT cord-010119-t1x9gknd 289 11 autoimmune autoimmune JJ cord-010119-t1x9gknd 289 12 disease disease NN cord-010119-t1x9gknd 289 13 model model NN cord-010119-t1x9gknd 289 14 . . . cord-010119-t1x9gknd 290 1 In in IN cord-010119-t1x9gknd 290 2 vitro vitro FW cord-010119-t1x9gknd 290 3 the the DT cord-010119-t1x9gknd 290 4 stability stability NN cord-010119-t1x9gknd 290 5 of of IN cord-010119-t1x9gknd 290 6 CD8 CD8 NNP cord-010119-t1x9gknd 290 7 1 1 CD cord-010119-t1x9gknd 290 8 Tregs Tregs NNP cord-010119-t1x9gknd 290 9 when when WRB cord-010119-t1x9gknd 290 10 encountering encounter VBG cord-010119-t1x9gknd 290 11 with with IN cord-010119-t1x9gknd 290 12 inflammation inflammation NN cord-010119-t1x9gknd 290 13 were be VBD cord-010119-t1x9gknd 290 14 test test NN cord-010119-t1x9gknd 290 15 by by IN cord-010119-t1x9gknd 290 16 Foxp3 foxp3 JJ cord-010119-t1x9gknd 290 17 expression expression NN cord-010119-t1x9gknd 290 18 , , , cord-010119-t1x9gknd 290 19 Th1 th1 NN cord-010119-t1x9gknd 290 20 and and CC cord-010119-t1x9gknd 290 21 Th17 Th17 NNP cord-010119-t1x9gknd 290 22 cells cell NNS cord-010119-t1x9gknd 290 23 conversion conversion NN cord-010119-t1x9gknd 290 24 in in IN cord-010119-t1x9gknd 290 25 inflammations inflammation NNS cord-010119-t1x9gknd 290 26 conditions condition NNS cord-010119-t1x9gknd 290 27 ( ( -LRB- cord-010119-t1x9gknd 290 28 IL21TGF il21tgf NN cord-010119-t1x9gknd 290 29 - - HYPH cord-010119-t1x9gknd 290 30 b11IL211IL23 b11IL211IL23 NNS cord-010119-t1x9gknd 290 31 and and CC cord-010119-t1x9gknd 290 32 IL21TGF il21tgf NN cord-010119-t1x9gknd 290 33 - - HYPH cord-010119-t1x9gknd 290 34 b11IL1b1IL6 b11il1b1il6 NN cord-010119-t1x9gknd 290 35 ) ) -RRB- cord-010119-t1x9gknd 290 36 on on IN cord-010119-t1x9gknd 290 37 day3 day3 NNP cord-010119-t1x9gknd 290 38 , , , cord-010119-t1x9gknd 290 39 day6 day6 NNP cord-010119-t1x9gknd 290 40 and and CC cord-010119-t1x9gknd 290 41 day9 day9 NNP cord-010119-t1x9gknd 290 42 . . . cord-010119-t1x9gknd 291 1 In in IN cord-010119-t1x9gknd 291 2 vivo vivo NN cord-010119-t1x9gknd 291 3 , , , cord-010119-t1x9gknd 291 4 CD8 CD8 NNP cord-010119-t1x9gknd 291 5 1 1 CD cord-010119-t1x9gknd 291 6 Tregs Tregs NNP cord-010119-t1x9gknd 291 7 were be VBD cord-010119-t1x9gknd 291 8 transfused transfuse VBN cord-010119-t1x9gknd 291 9 into into IN cord-010119-t1x9gknd 291 10 CIA CIA NNP cord-010119-t1x9gknd 291 11 mice mouse NNS cord-010119-t1x9gknd 291 12 and and CC cord-010119-t1x9gknd 291 13 then then RB cord-010119-t1x9gknd 291 14 their -PRON- PRP$ cord-010119-t1x9gknd 291 15 survival survival NN cord-010119-t1x9gknd 291 16 in in IN cord-010119-t1x9gknd 291 17 mice mouse NNS cord-010119-t1x9gknd 291 18 and and CC cord-010119-t1x9gknd 291 19 Foxp3 Foxp3 NNP cord-010119-t1x9gknd 291 20 express express NNP cord-010119-t1x9gknd 291 21 were be VBD cord-010119-t1x9gknd 291 22 evaluated evaluate VBN cord-010119-t1x9gknd 291 23 to to TO cord-010119-t1x9gknd 291 24 reveal reveal VB cord-010119-t1x9gknd 291 25 the the DT cord-010119-t1x9gknd 291 26 stability stability NN cord-010119-t1x9gknd 291 27 of of IN cord-010119-t1x9gknd 291 28 CD8 CD8 NNP cord-010119-t1x9gknd 291 29 1 1 CD cord-010119-t1x9gknd 291 30 Tregs Tregs NNP cord-010119-t1x9gknd 291 31 in in IN cord-010119-t1x9gknd 291 32 an an DT cord-010119-t1x9gknd 291 33 inflammation inflammation NN cord-010119-t1x9gknd 291 34 condition condition NN cord-010119-t1x9gknd 291 35 model model NN cord-010119-t1x9gknd 291 36 . . . cord-010119-t1x9gknd 292 1 Additionally additionally RB cord-010119-t1x9gknd 292 2 , , , cord-010119-t1x9gknd 292 3 we -PRON- PRP cord-010119-t1x9gknd 292 4 also also RB cord-010119-t1x9gknd 292 5 investigate investigate VBP cord-010119-t1x9gknd 292 6 the the DT cord-010119-t1x9gknd 292 7 stability stability NN cord-010119-t1x9gknd 292 8 maintenance maintenance NN cord-010119-t1x9gknd 292 9 of of IN cord-010119-t1x9gknd 292 10 CD8 CD8 NNP cord-010119-t1x9gknd 292 11 1 1 CD cord-010119-t1x9gknd 292 12 Tregs Tregs NNP cord-010119-t1x9gknd 292 13 when when WRB cord-010119-t1x9gknd 292 14 induced induce VBN cord-010119-t1x9gknd 292 15 factor factor NN cord-010119-t1x9gknd 292 16 TGF TGF NNP cord-010119-t1x9gknd 292 17 - - HYPH cord-010119-t1x9gknd 292 18 b1 b1 NN cord-010119-t1x9gknd 292 19 and and CC cord-010119-t1x9gknd 292 20 rapamycin rapamycin NNS cord-010119-t1x9gknd 292 21 were be VBD cord-010119-t1x9gknd 292 22 removed remove VBN cord-010119-t1x9gknd 292 23 by by IN cord-010119-t1x9gknd 292 24 testing test VBG cord-010119-t1x9gknd 292 25 the the DT cord-010119-t1x9gknd 292 26 Foxp3 foxp3 JJ cord-010119-t1x9gknd 292 27 expression expression NN cord-010119-t1x9gknd 292 28 on on IN cord-010119-t1x9gknd 292 29 day3 day3 NNP cord-010119-t1x9gknd 292 30 , , , cord-010119-t1x9gknd 292 31 day6 day6 NNP cord-010119-t1x9gknd 292 32 and and CC cord-010119-t1x9gknd 292 33 day9 day9 NNP cord-010119-t1x9gknd 292 34 . . . cord-010119-t1x9gknd 293 1 Results/ Results/ . cord-010119-t1x9gknd 294 1 Finding finding NN cord-010119-t1x9gknd 294 2 : : : cord-010119-t1x9gknd 295 1 Ex Ex NNP cord-010119-t1x9gknd 295 2 vivo vivo NNP cord-010119-t1x9gknd 295 3 induced induce VBD cord-010119-t1x9gknd 295 4 human human JJ cord-010119-t1x9gknd 295 5 CD8 CD8 NNP cord-010119-t1x9gknd 295 6 1 1 NNP cord-010119-t1x9gknd 295 7 Treg Treg NNP cord-010119-t1x9gknd 295 8 were be VBD cord-010119-t1x9gknd 295 9 Foxp3 foxp3 JJ cord-010119-t1x9gknd 295 10 1 1 CD cord-010119-t1x9gknd 296 1 ( ( -LRB- cord-010119-t1x9gknd 296 2 90.40 90.40 CD cord-010119-t1x9gknd 296 3 6 6 CD cord-010119-t1x9gknd 296 4 1.40 1.40 CD cord-010119-t1x9gknd 296 5 % % NN cord-010119-t1x9gknd 296 6 ) ) -RRB- cord-010119-t1x9gknd 296 7 and and CC cord-010119-t1x9gknd 296 8 did do VBD cord-010119-t1x9gknd 296 9 not not RB cord-010119-t1x9gknd 296 10 secret secret JJ cord-010119-t1x9gknd 296 11 IL17A il17a NN cord-010119-t1x9gknd 297 1 ( ( -LRB- cord-010119-t1x9gknd 297 2 both both DT cord-010119-t1x9gknd 297 3 in in IN cord-010119-t1x9gknd 297 4 supernatant supernatant NN cord-010119-t1x9gknd 297 5 and and CC cord-010119-t1x9gknd 297 6 % % NN cord-010119-t1x9gknd 297 7 of of IN cord-010119-t1x9gknd 297 8 cells cell NNS cord-010119-t1x9gknd 297 9 ) ) -RRB- cord-010119-t1x9gknd 297 10 . . . cord-010119-t1x9gknd 298 1 Foxp3 Foxp3 NNP cord-010119-t1x9gknd 298 2 express express NNP cord-010119-t1x9gknd 298 3 in in IN cord-010119-t1x9gknd 298 4 CD8 CD8 NNP cord-010119-t1x9gknd 298 5 1 1 CD cord-010119-t1x9gknd 298 6 Tregs Tregs NNP cord-010119-t1x9gknd 298 7 were be VBD cord-010119-t1x9gknd 298 8 maintained maintain VBN cord-010119-t1x9gknd 298 9 after after IN cord-010119-t1x9gknd 298 10 induced induce VBN cord-010119-t1x9gknd 298 11 factor factor NN cord-010119-t1x9gknd 298 12 TGF TGF NNP cord-010119-t1x9gknd 298 13 - - HYPH cord-010119-t1x9gknd 298 14 b1 b1 NN cord-010119-t1x9gknd 298 15 and and CC cord-010119-t1x9gknd 298 16 rapamycin rapamycin NNS cord-010119-t1x9gknd 298 17 were be VBD cord-010119-t1x9gknd 298 18 removed remove VBN cord-010119-t1x9gknd 298 19 on on IN cord-010119-t1x9gknd 298 20 day3 day3 NNP cord-010119-t1x9gknd 298 21 , , , cord-010119-t1x9gknd 298 22 day6 day6 NN cord-010119-t1x9gknd 298 23 and and CC cord-010119-t1x9gknd 298 24 day9 day9 NNP cord-010119-t1x9gknd 298 25 . . . cord-010119-t1x9gknd 299 1 In in IN cord-010119-t1x9gknd 299 2 vitro vitro FW cord-010119-t1x9gknd 299 3 , , , cord-010119-t1x9gknd 299 4 Foxp3 foxp3 JJ cord-010119-t1x9gknd 299 5 , , , cord-010119-t1x9gknd 299 6 IL2 IL2 NNP cord-010119-t1x9gknd 299 7 and and CC cord-010119-t1x9gknd 299 8 IFN IFN NNP cord-010119-t1x9gknd 299 9 - - HYPH cord-010119-t1x9gknd 299 10 c c NNP cord-010119-t1x9gknd 299 11 expression expression NN cord-010119-t1x9gknd 299 12 has have VBZ cord-010119-t1x9gknd 299 13 no no DT cord-010119-t1x9gknd 299 14 significant significant JJ cord-010119-t1x9gknd 299 15 difference difference NN cord-010119-t1x9gknd 299 16 when when WRB cord-010119-t1x9gknd 299 17 compared compare VBN cord-010119-t1x9gknd 299 18 with with IN cord-010119-t1x9gknd 299 19 controlled control VBN cord-010119-t1x9gknd 299 20 Tregs Tregs NNP cord-010119-t1x9gknd 299 21 on on IN cord-010119-t1x9gknd 299 22 day3 day3 NNP cord-010119-t1x9gknd 299 23 , , , cord-010119-t1x9gknd 299 24 day6 day6 NN cord-010119-t1x9gknd 299 25 and and CC cord-010119-t1x9gknd 299 26 day9 day9 NNP cord-010119-t1x9gknd 299 27 and and CC cord-010119-t1x9gknd 299 28 did do VBD cord-010119-t1x9gknd 299 29 not not RB cord-010119-t1x9gknd 299 30 secret secret JJ cord-010119-t1x9gknd 299 31 IL17A il17a NN cord-010119-t1x9gknd 299 32 when when WRB cord-010119-t1x9gknd 299 33 encounter encounter NN cord-010119-t1x9gknd 299 34 with with IN cord-010119-t1x9gknd 299 35 inflammation inflammation NN cord-010119-t1x9gknd 299 36 conditions condition NNS cord-010119-t1x9gknd 299 37 ( ( -LRB- cord-010119-t1x9gknd 299 38 IL21TGF il21tgf NN cord-010119-t1x9gknd 299 39 - - HYPH cord-010119-t1x9gknd 299 40 b11IL211IL23 b11IL211IL23 NNS cord-010119-t1x9gknd 299 41 and and CC cord-010119-t1x9gknd 299 42 IL21TGF il21tgf NN cord-010119-t1x9gknd 299 43 - - HYPH cord-010119-t1x9gknd 299 44 b11IL1b1IL6 b11il1b1il6 NN cord-010119-t1x9gknd 299 45 ) ) -RRB- cord-010119-t1x9gknd 299 46 . . . cord-010119-t1x9gknd 300 1 In in IN cord-010119-t1x9gknd 300 2 vivo vivo NN cord-010119-t1x9gknd 300 3 , , , cord-010119-t1x9gknd 300 4 CD81 CD81 NNP cord-010119-t1x9gknd 300 5 Treg Treg NNP cord-010119-t1x9gknd 300 6 cells cell NNS cord-010119-t1x9gknd 300 7 were be VBD cord-010119-t1x9gknd 300 8 transfused transfuse VBN cord-010119-t1x9gknd 300 9 into into IN cord-010119-t1x9gknd 300 10 CIA CIA NNP cord-010119-t1x9gknd 300 11 mice mouse NNS cord-010119-t1x9gknd 300 12 on on IN cord-010119-t1x9gknd 300 13 the the DT cord-010119-t1x9gknd 300 14 peak peak NN cord-010119-t1x9gknd 300 15 of of IN cord-010119-t1x9gknd 300 16 disease disease NN cord-010119-t1x9gknd 300 17 onset onset NN cord-010119-t1x9gknd 300 18 ( ( -LRB- cord-010119-t1x9gknd 300 19 35 35 CD cord-010119-t1x9gknd 300 20 days day NNS cord-010119-t1x9gknd 300 21 after after IN cord-010119-t1x9gknd 300 22 the the DT cord-010119-t1x9gknd 300 23 first first JJ cord-010119-t1x9gknd 300 24 Collagen Collagen NNP cord-010119-t1x9gknd 300 25 immunization immunization NN cord-010119-t1x9gknd 300 26 , , , cord-010119-t1x9gknd 300 27 has have VBZ cord-010119-t1x9gknd 300 28 inflammation inflammation NN cord-010119-t1x9gknd 300 29 condition condition NN cord-010119-t1x9gknd 300 30 in in IN cord-010119-t1x9gknd 300 31 vivo vivo NN cord-010119-t1x9gknd 300 32 ) ) -RRB- cord-010119-t1x9gknd 300 33 to to TO cord-010119-t1x9gknd 300 34 test test VB cord-010119-t1x9gknd 300 35 CD8 CD8 NNP cord-010119-t1x9gknd 300 36 1 1 CD cord-010119-t1x9gknd 300 37 Tregs Tregs NNP cord-010119-t1x9gknd 300 38 survival survival NN cord-010119-t1x9gknd 300 39 . . . cord-010119-t1x9gknd 301 1 CD8 CD8 NNP cord-010119-t1x9gknd 301 2 1 1 CD cord-010119-t1x9gknd 301 3 Tregs Tregs NNP cord-010119-t1x9gknd 301 4 were be VBD cord-010119-t1x9gknd 301 5 found find VBN cord-010119-t1x9gknd 301 6 in in IN cord-010119-t1x9gknd 301 7 CIA CIA NNP cord-010119-t1x9gknd 301 8 mice mouse NNS cord-010119-t1x9gknd 301 9 foot foot NN cord-010119-t1x9gknd 301 10 ( ( -LRB- cord-010119-t1x9gknd 301 11 27.4 27.4 CD cord-010119-t1x9gknd 301 12 6 6 CD cord-010119-t1x9gknd 301 13 2.03 2.03 CD cord-010119-t1x9gknd 301 14 % % NN cord-010119-t1x9gknd 301 15 ) ) -RRB- cord-010119-t1x9gknd 301 16 , , , cord-010119-t1x9gknd 301 17 blood blood NN cord-010119-t1x9gknd 301 18 ( ( -LRB- cord-010119-t1x9gknd 301 19 4.55 4.55 CD cord-010119-t1x9gknd 301 20 6 6 CD cord-010119-t1x9gknd 301 21 1.03 1.03 CD cord-010119-t1x9gknd 301 22 % % NN cord-010119-t1x9gknd 301 23 ) ) -RRB- cord-010119-t1x9gknd 301 24 and and CC cord-010119-t1x9gknd 301 25 spleen spleen NN cord-010119-t1x9gknd 301 26 cells cell NNS cord-010119-t1x9gknd 301 27 ( ( -LRB- cord-010119-t1x9gknd 301 28 1.90 1.90 CD cord-010119-t1x9gknd 301 29 6 6 CD cord-010119-t1x9gknd 301 30 0.05 0.05 CD cord-010119-t1x9gknd 301 31 % % NN cord-010119-t1x9gknd 301 32 ) ) -RRB- cord-010119-t1x9gknd 301 33 72 72 CD cord-010119-t1x9gknd 301 34 hours hour NNS cord-010119-t1x9gknd 301 35 after after IN cord-010119-t1x9gknd 301 36 transfusion transfusion NN cord-010119-t1x9gknd 301 37 and and CC cord-010119-t1x9gknd 301 38 their -PRON- PRP$ cord-010119-t1x9gknd 301 39 % % NN cord-010119-t1x9gknd 301 40 of of IN cord-010119-t1x9gknd 301 41 foxp3 foxp3 NN cord-010119-t1x9gknd 301 42 1 1 CD cord-010119-t1x9gknd 301 43 were be VBD cord-010119-t1x9gknd 301 44 remained remain VBN cord-010119-t1x9gknd 301 45 . . . cord-010119-t1x9gknd 302 1 Conclusion conclusion NN cord-010119-t1x9gknd 302 2 : : : cord-010119-t1x9gknd 303 1 The the DT cord-010119-t1x9gknd 303 2 results result NNS cord-010119-t1x9gknd 303 3 revealed reveal VBD cord-010119-t1x9gknd 303 4 that that IN cord-010119-t1x9gknd 303 5 ex ex NN cord-010119-t1x9gknd 303 6 - - NN cord-010119-t1x9gknd 303 7 vivo vivo JJ cord-010119-t1x9gknd 303 8 induced induce VBN cord-010119-t1x9gknd 303 9 and and CC cord-010119-t1x9gknd 303 10 expanded expand VBN cord-010119-t1x9gknd 304 1 human human JJ cord-010119-t1x9gknd 304 2 CD8 CD8 NNP cord-010119-t1x9gknd 304 3 1 1 CD cord-010119-t1x9gknd 304 4 Tregs Tregs NNP cord-010119-t1x9gknd 304 5 are be VBP cord-010119-t1x9gknd 304 6 stable stable JJ cord-010119-t1x9gknd 304 7 in in IN cord-010119-t1x9gknd 304 8 inflammation inflammation NN cord-010119-t1x9gknd 304 9 and and CC cord-010119-t1x9gknd 304 10 transfusion transfusion NN cord-010119-t1x9gknd 304 11 and and CC cord-010119-t1x9gknd 304 12 can can MD cord-010119-t1x9gknd 304 13 maintain maintain VB cord-010119-t1x9gknd 304 14 Foxp3 foxp3 JJ cord-010119-t1x9gknd 304 15 expression expression NN cord-010119-t1x9gknd 304 16 when when WRB cord-010119-t1x9gknd 304 17 induced induce VBN cord-010119-t1x9gknd 304 18 factor factor NN cord-010119-t1x9gknd 304 19 were be VBD cord-010119-t1x9gknd 304 20 removed remove VBN cord-010119-t1x9gknd 304 21 , , , cord-010119-t1x9gknd 304 22 these these DT cord-010119-t1x9gknd 304 23 make make VBP cord-010119-t1x9gknd 304 24 CD8 CD8 NNP cord-010119-t1x9gknd 304 25 1 1 CD cord-010119-t1x9gknd 304 26 Treg Treg NNP cord-010119-t1x9gknd 304 27 a a DT cord-010119-t1x9gknd 304 28 novel novel JJ cord-010119-t1x9gknd 304 29 and and CC cord-010119-t1x9gknd 304 30 stable stable JJ cord-010119-t1x9gknd 304 31 cell cell NN cord-010119-t1x9gknd 304 32 for for IN cord-010119-t1x9gknd 304 33 potential potential JJ cord-010119-t1x9gknd 304 34 cell cell NN cord-010119-t1x9gknd 304 35 therapy therapy NN cord-010119-t1x9gknd 304 36 on on IN cord-010119-t1x9gknd 304 37 AIDs AIDs NNP cord-010119-t1x9gknd 304 38 . . . cord-010119-t1x9gknd 305 1 This this DT cord-010119-t1x9gknd 305 2 research research NN cord-010119-t1x9gknd 305 3 can can MD cord-010119-t1x9gknd 305 4 provide provide VB cord-010119-t1x9gknd 305 5 some some DT cord-010119-t1x9gknd 305 6 instructive instructive JJ cord-010119-t1x9gknd 305 7 reference reference NN cord-010119-t1x9gknd 305 8 and and CC cord-010119-t1x9gknd 305 9 improve improve VB cord-010119-t1x9gknd 305 10 the the DT cord-010119-t1x9gknd 305 11 utilization utilization NN cord-010119-t1x9gknd 305 12 of of IN cord-010119-t1x9gknd 305 13 blood blood NN cord-010119-t1x9gknd 305 14 components component NNS cord-010119-t1x9gknd 305 15 . . . cord-010119-t1x9gknd 306 1 Tolerogenic Tolerogenic NNP cord-010119-t1x9gknd 306 2 Dendritic Dendritic NNP cord-010119-t1x9gknd 306 3 Cells cell NNS cord-010119-t1x9gknd 306 4 Induced induce VBN cord-010119-t1x9gknd 306 5 By by IN cord-010119-t1x9gknd 306 6 mTOR mTOR NNP cord-010119-t1x9gknd 306 7 Suppression Suppression NNP cord-010119-t1x9gknd 306 8 and and CC cord-010119-t1x9gknd 306 9 Control Control NNP cord-010119-t1x9gknd 306 10 Inflammation inflammation NN cord-010119-t1x9gknd 306 11 in in IN cord-010119-t1x9gknd 306 12 Chs Chs NNP cord-010119-t1x9gknd 306 13 Model Model NNP cord-010119-t1x9gknd 306 14 through through IN cord-010119-t1x9gknd 306 15 S6 S6 NNP cord-010119-t1x9gknd 306 16 K K NNP cord-010119-t1x9gknd 306 17 Related Related NNP cord-010119-t1x9gknd 306 18 Proteins Proteins NNP cord-010119-t1x9gknd 306 19 Translation Translation NNP cord-010119-t1x9gknd 306 20 Inhibition inhibition NN cord-010119-t1x9gknd 306 21 . . . cord-010119-t1x9gknd 307 1 Li Li NNP cord-010119-t1x9gknd 307 2 GAO GAO NNP cord-010119-t1x9gknd 308 1 * * NFP cord-010119-t1x9gknd 308 2 . . . cord-010119-t1x9gknd 309 1 Shanghai Shanghai NNP cord-010119-t1x9gknd 309 2 Blood Blood NNP cord-010119-t1x9gknd 309 3 Center Center NNP cord-010119-t1x9gknd 309 4 Background Background NNP cord-010119-t1x9gknd 309 5 / / SYM cord-010119-t1x9gknd 309 6 Case Case NNP cord-010119-t1x9gknd 309 7 Studies Studies NNPS cord-010119-t1x9gknd 309 8 : : : cord-010119-t1x9gknd 310 1 Tolerogenic Tolerogenic NNP cord-010119-t1x9gknd 310 2 dendritic dendritic JJ cord-010119-t1x9gknd 310 3 cells cell NNS cord-010119-t1x9gknd 310 4 ( ( -LRB- cord-010119-t1x9gknd 310 5 tDCs tDCs NNP cord-010119-t1x9gknd 310 6 ) ) -RRB- cord-010119-t1x9gknd 311 1 adoptive adoptive JJ cord-010119-t1x9gknd 311 2 cellular cellular JJ cord-010119-t1x9gknd 311 3 immunotherapy immunotherapy NN cord-010119-t1x9gknd 311 4 is be VBZ cord-010119-t1x9gknd 311 5 a a DT cord-010119-t1x9gknd 311 6 cutting cut VBG cord-010119-t1x9gknd 311 7 edge edge NN cord-010119-t1x9gknd 311 8 strategy strategy NN cord-010119-t1x9gknd 311 9 for for IN cord-010119-t1x9gknd 311 10 treating treat VBG cord-010119-t1x9gknd 311 11 hypersensitivity hypersensitivity NN cord-010119-t1x9gknd 311 12 response response NN cord-010119-t1x9gknd 311 13 disease disease NN cord-010119-t1x9gknd 311 14 , , , cord-010119-t1x9gknd 311 15 in in IN cord-010119-t1x9gknd 311 16 which which WDT cord-010119-t1x9gknd 311 17 immune immune JJ cord-010119-t1x9gknd 311 18 responses response NNS cord-010119-t1x9gknd 311 19 are be VBP cord-010119-t1x9gknd 311 20 directed direct VBN cord-010119-t1x9gknd 311 21 against against IN cord-010119-t1x9gknd 311 22 selfantigens selfantigens NNP cord-010119-t1x9gknd 311 23 , , , cord-010119-t1x9gknd 311 24 such such JJ cord-010119-t1x9gknd 311 25 as as IN cord-010119-t1x9gknd 311 26 atopic atopic JJ cord-010119-t1x9gknd 311 27 dermatitis dermatitis NN cord-010119-t1x9gknd 311 28 , , , cord-010119-t1x9gknd 311 29 systemic systemic JJ cord-010119-t1x9gknd 311 30 lupus lupus NN cord-010119-t1x9gknd 311 31 erythematosus erythematosus NN cord-010119-t1x9gknd 311 32 ( ( -LRB- cord-010119-t1x9gknd 311 33 SLE SLE NNP cord-010119-t1x9gknd 311 34 ) ) -RRB- cord-010119-t1x9gknd 311 35 , , , cord-010119-t1x9gknd 311 36 rheumatoid rheumatoid NN cord-010119-t1x9gknd 311 37 arthritis arthritis NN cord-010119-t1x9gknd 311 38 ( ( -LRB- cord-010119-t1x9gknd 311 39 RA),et RA),et NNP cord-010119-t1x9gknd 311 40 al al NNP cord-010119-t1x9gknd 311 41 . . . cord-010119-t1x9gknd 312 1 However however RB cord-010119-t1x9gknd 312 2 , , , cord-010119-t1x9gknd 312 3 the the DT cord-010119-t1x9gknd 312 4 traditional traditional JJ cord-010119-t1x9gknd 312 5 strategy strategy NN cord-010119-t1x9gknd 312 6 base base NN cord-010119-t1x9gknd 312 7 on on IN cord-010119-t1x9gknd 312 8 the the DT cord-010119-t1x9gknd 312 9 tDCs tdcs NN cord-010119-t1x9gknd 312 10 was be VBD cord-010119-t1x9gknd 312 11 usually usually RB cord-010119-t1x9gknd 312 12 unstable unstable JJ cord-010119-t1x9gknd 312 13 and and CC cord-010119-t1x9gknd 312 14 inconspicuous inconspicuous JJ cord-010119-t1x9gknd 312 15 through through IN cord-010119-t1x9gknd 312 16 cytokines cytokine NNS cord-010119-t1x9gknd 312 17 inducing induce VBG cord-010119-t1x9gknd 312 18 processing processing NN cord-010119-t1x9gknd 312 19 so so IN cord-010119-t1x9gknd 312 20 that that DT cord-010119-t1x9gknd 312 21 might may MD cord-010119-t1x9gknd 312 22 be be VB cord-010119-t1x9gknd 312 23 the the DT cord-010119-t1x9gknd 312 24 limitations limitation NNS cord-010119-t1x9gknd 312 25 on on IN cord-010119-t1x9gknd 312 26 tDC tdc DT cord-010119-t1x9gknd 312 27 adaptive adaptive JJ cord-010119-t1x9gknd 312 28 cell cell NN cord-010119-t1x9gknd 312 29 therapy therapy NN cord-010119-t1x9gknd 312 30 in in IN cord-010119-t1x9gknd 312 31 future future JJ cord-010119-t1x9gknd 312 32 clinical clinical JJ cord-010119-t1x9gknd 312 33 use use NN cord-010119-t1x9gknd 312 34 . . . cord-010119-t1x9gknd 313 1 Study Study NNP cord-010119-t1x9gknd 313 2 Design Design NNP cord-010119-t1x9gknd 313 3 / / SYM cord-010119-t1x9gknd 313 4 Method method NN cord-010119-t1x9gknd 313 5 : : : cord-010119-t1x9gknd 314 1 Human human JJ cord-010119-t1x9gknd 314 2 tDCs tdc NNS cord-010119-t1x9gknd 314 3 were be VBD cord-010119-t1x9gknd 314 4 derived derive VBN cord-010119-t1x9gknd 314 5 from from IN cord-010119-t1x9gknd 314 6 fresh fresh JJ cord-010119-t1x9gknd 314 7 purified purify VBN cord-010119-t1x9gknd 314 8 monocytes monocyte NNS cord-010119-t1x9gknd 314 9 from from IN cord-010119-t1x9gknd 314 10 PBMNCs pbmnc NNS cord-010119-t1x9gknd 314 11 isolated isolate VBN cord-010119-t1x9gknd 314 12 from from IN cord-010119-t1x9gknd 314 13 buffy buffy NNP cord-010119-t1x9gknd 314 14 coat coat NNP cord-010119-t1x9gknd 314 15 and and CC cord-010119-t1x9gknd 314 16 induced induce VBN cord-010119-t1x9gknd 314 17 by by IN cord-010119-t1x9gknd 314 18 mTOR mTOR NNP cord-010119-t1x9gknd 314 19 inhibitors inhibitor NNS cord-010119-t1x9gknd 314 20 ( ( -LRB- cord-010119-t1x9gknd 314 21 rapamycin rapamycin NNP cord-010119-t1x9gknd 314 22 and and CC cord-010119-t1x9gknd 314 23 temsirolimus temsirolimus NNP cord-010119-t1x9gknd 314 24 ) ) -RRB- cord-010119-t1x9gknd 314 25 in in IN cord-010119-t1x9gknd 314 26 safe safe JJ cord-010119-t1x9gknd 314 27 concentrations concentration NNS cord-010119-t1x9gknd 314 28 confirmed confirm VBN cord-010119-t1x9gknd 314 29 by by IN cord-010119-t1x9gknd 314 30 apoptosis apoptosis NN cord-010119-t1x9gknd 314 31 assay assay NN cord-010119-t1x9gknd 314 32 when when WRB cord-010119-t1x9gknd 314 33 the the DT cord-010119-t1x9gknd 314 34 cells cell NNS cord-010119-t1x9gknd 314 35 were be VBD cord-010119-t1x9gknd 314 36 completely completely RB cord-010119-t1x9gknd 314 37 differentiated differentiate VBN cord-010119-t1x9gknd 314 38 . . . cord-010119-t1x9gknd 315 1 The the DT cord-010119-t1x9gknd 315 2 mature mature JJ cord-010119-t1x9gknd 315 3 markers marker NNS cord-010119-t1x9gknd 315 4 and and CC cord-010119-t1x9gknd 315 5 endocytisis endocytisis NN cord-010119-t1x9gknd 315 6 were be VBD cord-010119-t1x9gknd 315 7 detected detect VBN cord-010119-t1x9gknd 315 8 by by IN cord-010119-t1x9gknd 315 9 flow flow NN cord-010119-t1x9gknd 315 10 cytometry cytometry NN cord-010119-t1x9gknd 315 11 . . . cord-010119-t1x9gknd 316 1 The the DT cord-010119-t1x9gknd 316 2 production production NN cord-010119-t1x9gknd 316 3 of of IN cord-010119-t1x9gknd 316 4 cytokines cytokine NNS cord-010119-t1x9gknd 316 5 and and CC cord-010119-t1x9gknd 316 6 chemokines chemokine NNS cord-010119-t1x9gknd 316 7 was be VBD cord-010119-t1x9gknd 316 8 measured measure VBN cord-010119-t1x9gknd 316 9 using use VBG cord-010119-t1x9gknd 316 10 ELISA ELISA NNP cord-010119-t1x9gknd 316 11 . . . cord-010119-t1x9gknd 317 1 Mechanism mechanism NN cord-010119-t1x9gknd 317 2 investigation investigation NN cord-010119-t1x9gknd 317 3 was be VBD cord-010119-t1x9gknd 317 4 analysis analysis NN cord-010119-t1x9gknd 317 5 by by IN cord-010119-t1x9gknd 317 6 Real real JJ cord-010119-t1x9gknd 317 7 - - HYPH cord-010119-t1x9gknd 317 8 time time NN cord-010119-t1x9gknd 317 9 PCR PCR NNP cord-010119-t1x9gknd 317 10 and and CC cord-010119-t1x9gknd 317 11 Western western JJ cord-010119-t1x9gknd 317 12 blotting blotting NN cord-010119-t1x9gknd 317 13 . . . cord-010119-t1x9gknd 318 1 Contact contact NN cord-010119-t1x9gknd 318 2 hypersensitivity hypersensitivity NN cord-010119-t1x9gknd 318 3 ( ( -LRB- cord-010119-t1x9gknd 318 4 CHS CHS NNP cord-010119-t1x9gknd 318 5 ) ) -RRB- cord-010119-t1x9gknd 318 6 model model NN cord-010119-t1x9gknd 318 7 , , , cord-010119-t1x9gknd 318 8 an an DT cord-010119-t1x9gknd 318 9 atopic atopic JJ cord-010119-t1x9gknd 318 10 dermatitis dermatitis NN cord-010119-t1x9gknd 318 11 animal animal NN cord-010119-t1x9gknd 318 12 model model NN cord-010119-t1x9gknd 318 13 , , , cord-010119-t1x9gknd 318 14 was be VBD cord-010119-t1x9gknd 318 15 treated treat VBN cord-010119-t1x9gknd 318 16 with with IN cord-010119-t1x9gknd 318 17 tDCs tDCs NNP cord-010119-t1x9gknd 318 18 induced induce VBN cord-010119-t1x9gknd 318 19 via via IN cord-010119-t1x9gknd 318 20 mTOR mTOR NNP cord-010119-t1x9gknd 318 21 suppression suppression NN cord-010119-t1x9gknd 318 22 and and CC cord-010119-t1x9gknd 318 23 analyzed analyze VBN cord-010119-t1x9gknd 318 24 by by IN cord-010119-t1x9gknd 318 25 ear ear NN cord-010119-t1x9gknd 318 26 thickness thickness NN cord-010119-t1x9gknd 318 27 and and CC cord-010119-t1x9gknd 318 28 tissue tissue NN cord-010119-t1x9gknd 318 29 leukocytes leukocyte NNS cord-010119-t1x9gknd 318 30 number number NN cord-010119-t1x9gknd 318 31 calculating calculate VBG cord-010119-t1x9gknd 318 32 . . . cord-010119-t1x9gknd 319 1 Results/ Results/ . cord-010119-t1x9gknd 320 1 Finding finding NN cord-010119-t1x9gknd 320 2 : : : cord-010119-t1x9gknd 321 1 Human human JJ cord-010119-t1x9gknd 321 2 tDCs tdcs CD cord-010119-t1x9gknd 321 3 treated treat VBN cord-010119-t1x9gknd 321 4 with with IN cord-010119-t1x9gknd 321 5 mTOR mTOR NNP cord-010119-t1x9gknd 321 6 inhibitors inhibitor NNS cord-010119-t1x9gknd 321 7 had have VBD cord-010119-t1x9gknd 322 1 a a DT cord-010119-t1x9gknd 322 2 lower lower RBR cord-010119-t1x9gknd 322 3 mature mature JJ cord-010119-t1x9gknd 322 4 marker marker NN cord-010119-t1x9gknd 322 5 CD83 CD83 NNP cord-010119-t1x9gknd 322 6 / / SYM cord-010119-t1x9gknd 322 7 CD80 CD80 NNP cord-010119-t1x9gknd 322 8 / / SYM cord-010119-t1x9gknd 322 9 CD86 CD86 NNP cord-010119-t1x9gknd 322 10 expression expression NN cord-010119-t1x9gknd 322 11 after after IN cord-010119-t1x9gknd 322 12 TLR TLR NNP cord-010119-t1x9gknd 322 13 signaling signal VBG cord-010119-t1x9gknd 322 14 activation activation NN cord-010119-t1x9gknd 322 15 , , , cord-010119-t1x9gknd 322 16 accompanied accompany VBN cord-010119-t1x9gknd 322 17 with with IN cord-010119-t1x9gknd 322 18 a a DT cord-010119-t1x9gknd 322 19 set set NN cord-010119-t1x9gknd 322 20 of of IN cord-010119-t1x9gknd 322 21 cytokines cytokine NNS cord-010119-t1x9gknd 322 22 and and CC cord-010119-t1x9gknd 322 23 chemokines chemokine NNS cord-010119-t1x9gknd 322 24 remarkably remarkably RB cord-010119-t1x9gknd 322 25 downregulated downregulate VBD cord-010119-t1x9gknd 322 26 in in IN cord-010119-t1x9gknd 322 27 a a DT cord-010119-t1x9gknd 322 28 concentration concentration NN cord-010119-t1x9gknd 322 29 dependent dependent JJ cord-010119-t1x9gknd 322 30 manner manner NN cord-010119-t1x9gknd 322 31 but but CC cord-010119-t1x9gknd 322 32 not not RB cord-010119-t1x9gknd 322 33 the the DT cord-010119-t1x9gknd 322 34 LPS LPS NNP cord-010119-t1x9gknd 322 35 absent absent JJ cord-010119-t1x9gknd 322 36 group group NN cord-010119-t1x9gknd 322 37 . . . cord-010119-t1x9gknd 323 1 Moreover moreover RB cord-010119-t1x9gknd 323 2 , , , cord-010119-t1x9gknd 323 3 mTOR mTOR NNP cord-010119-t1x9gknd 323 4 suppression suppression NN cord-010119-t1x9gknd 323 5 extremely extremely RB cord-010119-t1x9gknd 323 6 reduced reduce VBD cord-010119-t1x9gknd 323 7 the the DT cord-010119-t1x9gknd 323 8 capacity capacity NN cord-010119-t1x9gknd 323 9 of of IN cord-010119-t1x9gknd 323 10 LPS LPS NNP cord-010119-t1x9gknd 323 11 treated treat VBD cord-010119-t1x9gknd 323 12 human human JJ cord-010119-t1x9gknd 323 13 DCs dc NNS cord-010119-t1x9gknd 323 14 to to TO cord-010119-t1x9gknd 323 15 stimulate stimulate VB cord-010119-t1x9gknd 323 16 autogenic autogenic NNP cord-010119-t1x9gknd 323 17 na€ na€ NNS cord-010119-t1x9gknd 323 18 ıve ıve JJ cord-010119-t1x9gknd 323 19 T t NN cord-010119-t1x9gknd 323 20 cell cell NN cord-010119-t1x9gknd 323 21 proliferation proliferation NN cord-010119-t1x9gknd 323 22 , , , cord-010119-t1x9gknd 323 23 which which WDT cord-010119-t1x9gknd 323 24 is be VBZ cord-010119-t1x9gknd 323 25 one one CD cord-010119-t1x9gknd 323 26 of of IN cord-010119-t1x9gknd 323 27 the the DT cord-010119-t1x9gknd 323 28 most most RBS cord-010119-t1x9gknd 323 29 important important JJ cord-010119-t1x9gknd 323 30 characteristics characteristic NNS cord-010119-t1x9gknd 323 31 of of IN cord-010119-t1x9gknd 323 32 tDC tdc CD cord-010119-t1x9gknd 323 33 . . . cord-010119-t1x9gknd 324 1 Beyond beyond IN cord-010119-t1x9gknd 324 2 expectation expectation NN cord-010119-t1x9gknd 324 3 , , , cord-010119-t1x9gknd 324 4 the the DT cord-010119-t1x9gknd 324 5 common common JJ cord-010119-t1x9gknd 324 6 signal signal NN cord-010119-t1x9gknd 324 7 transduction transduction NN cord-010119-t1x9gknd 324 8 pathway pathway NN cord-010119-t1x9gknd 324 9 , , , cord-010119-t1x9gknd 324 10 MAPK MAPK NNP cord-010119-t1x9gknd 324 11 and and CC cord-010119-t1x9gknd 324 12 NF nf NN cord-010119-t1x9gknd 324 13 - - HYPH cord-010119-t1x9gknd 324 14 jB jB NNP cord-010119-t1x9gknd 324 15 pathway pathway NN cord-010119-t1x9gknd 324 16 , , , cord-010119-t1x9gknd 324 17 were be VBD cord-010119-t1x9gknd 324 18 not not RB cord-010119-t1x9gknd 324 19 the the DT cord-010119-t1x9gknd 324 20 signal signal NN cord-010119-t1x9gknd 324 21 target target NN cord-010119-t1x9gknd 324 22 so so IN cord-010119-t1x9gknd 324 23 that that IN cord-010119-t1x9gknd 324 24 it -PRON- PRP cord-010119-t1x9gknd 324 25 could could MD cord-010119-t1x9gknd 324 26 hardly hardly RB cord-010119-t1x9gknd 324 27 be be VB cord-010119-t1x9gknd 324 28 the the DT cord-010119-t1x9gknd 324 29 explanation explanation NN cord-010119-t1x9gknd 324 30 for for IN cord-010119-t1x9gknd 324 31 the the DT cord-010119-t1x9gknd 324 32 tolerogenic tolerogenic NNP cord-010119-t1x9gknd 324 33 performance performance NN cord-010119-t1x9gknd 324 34 of of IN cord-010119-t1x9gknd 324 35 tDC tdc DT cord-010119-t1x9gknd 324 36 when when WRB cord-010119-t1x9gknd 324 37 exposure exposure NN cord-010119-t1x9gknd 324 38 to to IN cord-010119-t1x9gknd 324 39 LPS LPS NNP cord-010119-t1x9gknd 324 40 stimulation stimulation NN cord-010119-t1x9gknd 324 41 . . . cord-010119-t1x9gknd 325 1 However however RB cord-010119-t1x9gknd 325 2 , , , cord-010119-t1x9gknd 325 3 the the DT cord-010119-t1x9gknd 325 4 P70S6 P70S6 NNP cord-010119-t1x9gknd 325 5 K K NNP cord-010119-t1x9gknd 325 6 and and CC cord-010119-t1x9gknd 325 7 its -PRON- PRP$ cord-010119-t1x9gknd 325 8 downstreanm downstreanm NN cord-010119-t1x9gknd 325 9 proteins protein NNS cord-010119-t1x9gknd 325 10 , , , cord-010119-t1x9gknd 325 11 especially especially RB cord-010119-t1x9gknd 325 12 the the DT cord-010119-t1x9gknd 325 13 protein protein NN cord-010119-t1x9gknd 325 14 S6 S6 NNP cord-010119-t1x9gknd 325 15 , , , cord-010119-t1x9gknd 325 16 which which WDT cord-010119-t1x9gknd 325 17 controls control VBZ cord-010119-t1x9gknd 325 18 the the DT cord-010119-t1x9gknd 325 19 protein protein NN cord-010119-t1x9gknd 325 20 translation translation NN cord-010119-t1x9gknd 325 21 , , , cord-010119-t1x9gknd 325 22 were be VBD cord-010119-t1x9gknd 325 23 shown show VBN cord-010119-t1x9gknd 325 24 in in IN cord-010119-t1x9gknd 325 25 charge charge NN cord-010119-t1x9gknd 325 26 of of IN cord-010119-t1x9gknd 325 27 the the DT cord-010119-t1x9gknd 325 28 tolerogenic tolerogenic NNP cord-010119-t1x9gknd 325 29 induction induction NN cord-010119-t1x9gknd 325 30 mechanism mechanism NN cord-010119-t1x9gknd 325 31 . . . cord-010119-t1x9gknd 326 1 The the DT cord-010119-t1x9gknd 326 2 data datum NNS cord-010119-t1x9gknd 326 3 were be VBD cord-010119-t1x9gknd 326 4 also also RB cord-010119-t1x9gknd 326 5 supporting support VBG cord-010119-t1x9gknd 326 6 the the DT cord-010119-t1x9gknd 326 7 suggestion suggestion NN cord-010119-t1x9gknd 326 8 that that IN cord-010119-t1x9gknd 326 9 rare rare JJ cord-010119-t1x9gknd 326 10 difference difference NN cord-010119-t1x9gknd 326 11 on on IN cord-010119-t1x9gknd 326 12 mRNA mrna NN cord-010119-t1x9gknd 326 13 transcription transcription NN cord-010119-t1x9gknd 326 14 of of IN cord-010119-t1x9gknd 326 15 the the DT cord-010119-t1x9gknd 326 16 related related JJ cord-010119-t1x9gknd 326 17 functional functional JJ cord-010119-t1x9gknd 326 18 proteins protein NNS cord-010119-t1x9gknd 326 19 in in IN cord-010119-t1x9gknd 326 20 tDCs tdcs CD cord-010119-t1x9gknd 326 21 induced induce VBN cord-010119-t1x9gknd 326 22 by by IN cord-010119-t1x9gknd 326 23 mTOR mTOR NNP cord-010119-t1x9gknd 326 24 inhibitors inhibitor NNS cord-010119-t1x9gknd 326 25 when when WRB cord-010119-t1x9gknd 326 26 exposure exposure NN cord-010119-t1x9gknd 326 27 to to IN cord-010119-t1x9gknd 326 28 LPS LPS NNP cord-010119-t1x9gknd 326 29 stimulation stimulation NN cord-010119-t1x9gknd 326 30 from from IN cord-010119-t1x9gknd 326 31 the the DT cord-010119-t1x9gknd 326 32 non non JJ cord-010119-t1x9gknd 326 33 - - JJ cord-010119-t1x9gknd 326 34 induced induced JJ cord-010119-t1x9gknd 326 35 cells cell NNS cord-010119-t1x9gknd 326 36 , , , cord-010119-t1x9gknd 326 37 although although IN cord-010119-t1x9gknd 326 38 there there EX cord-010119-t1x9gknd 326 39 was be VBD cord-010119-t1x9gknd 326 40 more more JJR cord-010119-t1x9gknd 326 41 transcription transcription NN cord-010119-t1x9gknd 326 42 of of IN cord-010119-t1x9gknd 326 43 IDO IDO NNP cord-010119-t1x9gknd 326 44 induced induce VBN cord-010119-t1x9gknd 326 45 by by IN cord-010119-t1x9gknd 326 46 mTOR mTOR NNP cord-010119-t1x9gknd 326 47 inhibitors inhibitor NNS cord-010119-t1x9gknd 326 48 . . . cord-010119-t1x9gknd 327 1 More more RBR cord-010119-t1x9gknd 327 2 important important JJ cord-010119-t1x9gknd 327 3 , , , cord-010119-t1x9gknd 327 4 edema edema NN cord-010119-t1x9gknd 327 5 responses response NNS cord-010119-t1x9gknd 327 6 of of IN cord-010119-t1x9gknd 327 7 ears ear NNS cord-010119-t1x9gknd 327 8 were be VBD cord-010119-t1x9gknd 327 9 clearly clearly RB cord-010119-t1x9gknd 327 10 weakened weaken VBN cord-010119-t1x9gknd 327 11 in in IN cord-010119-t1x9gknd 327 12 the the DT cord-010119-t1x9gknd 327 13 CHS CHS NNP cord-010119-t1x9gknd 327 14 model model NN cord-010119-t1x9gknd 327 15 and and CC cord-010119-t1x9gknd 327 16 recruited recruit VBD cord-010119-t1x9gknd 327 17 less less JJR cord-010119-t1x9gknd 327 18 leukocytes leukocyte NNS cord-010119-t1x9gknd 327 19 to to IN cord-010119-t1x9gknd 327 20 the the DT cord-010119-t1x9gknd 327 21 tissue tissue NN cord-010119-t1x9gknd 327 22 when when WRB cord-010119-t1x9gknd 327 23 co co NN cord-010119-t1x9gknd 327 24 - - VBN cord-010119-t1x9gknd 327 25 sensitized sensitize VBN cord-010119-t1x9gknd 327 26 with with IN cord-010119-t1x9gknd 327 27 mTOR mTOR NNP cord-010119-t1x9gknd 327 28 inhibitors inhibitor NNS cord-010119-t1x9gknd 327 29 or or CC cord-010119-t1x9gknd 327 30 with with IN cord-010119-t1x9gknd 327 31 tDCs tDCs NNP cord-010119-t1x9gknd 327 32 induced induce VBN cord-010119-t1x9gknd 327 33 by by IN cord-010119-t1x9gknd 327 34 mTOR mTOR NNP cord-010119-t1x9gknd 327 35 inhibitors inhibitor NNS cord-010119-t1x9gknd 327 36 suggested suggest VBD cord-010119-t1x9gknd 327 37 that that IN cord-010119-t1x9gknd 327 38 the the DT cord-010119-t1x9gknd 327 39 tDC tdc DT cord-010119-t1x9gknd 327 40 induced induce VBN cord-010119-t1x9gknd 327 41 by by IN cord-010119-t1x9gknd 327 42 mTOR mTOR NNP cord-010119-t1x9gknd 327 43 suppression suppression NN cord-010119-t1x9gknd 327 44 were be VBD cord-010119-t1x9gknd 327 45 able able JJ cord-010119-t1x9gknd 327 46 to to TO cord-010119-t1x9gknd 327 47 control control VB cord-010119-t1x9gknd 327 48 hypersensitivity hypersensitivity NN cord-010119-t1x9gknd 327 49 inflammation inflammation NN cord-010119-t1x9gknd 327 50 response response NN cord-010119-t1x9gknd 327 51 in in IN cord-010119-t1x9gknd 327 52 vivo vivo NNP cord-010119-t1x9gknd 327 53 . . . cord-010119-t1x9gknd 328 1 Conclusion conclusion NN cord-010119-t1x9gknd 328 2 : : : cord-010119-t1x9gknd 328 3 Accordingly accordingly RB cord-010119-t1x9gknd 328 4 , , , cord-010119-t1x9gknd 328 5 tDC tdc DT cord-010119-t1x9gknd 328 6 induced induce VBN cord-010119-t1x9gknd 328 7 by by IN cord-010119-t1x9gknd 328 8 mTOR mTOR NNP cord-010119-t1x9gknd 328 9 suppression suppression NN cord-010119-t1x9gknd 328 10 is be VBZ cord-010119-t1x9gknd 328 11 a a DT cord-010119-t1x9gknd 328 12 potent potent JJ cord-010119-t1x9gknd 328 13 adoptive adoptive JJ cord-010119-t1x9gknd 328 14 cellular cellular JJ cord-010119-t1x9gknd 328 15 immunotherapy immunotherapy NN cord-010119-t1x9gknd 328 16 strategy strategy NN cord-010119-t1x9gknd 328 17 for for IN cord-010119-t1x9gknd 328 18 treating treat VBG cord-010119-t1x9gknd 328 19 hypersensitivity hypersensitivity NN cord-010119-t1x9gknd 328 20 response response NN cord-010119-t1x9gknd 328 21 disease disease NN cord-010119-t1x9gknd 328 22 and and CC cord-010119-t1x9gknd 328 23 the the DT cord-010119-t1x9gknd 328 24 induction induction NN cord-010119-t1x9gknd 328 25 mechanism mechanism NN cord-010119-t1x9gknd 328 26 of of IN cord-010119-t1x9gknd 328 27 it -PRON- PRP cord-010119-t1x9gknd 328 28 might may MD cord-010119-t1x9gknd 328 29 be be VB cord-010119-t1x9gknd 328 30 through through IN cord-010119-t1x9gknd 328 31 suppressing suppress VBG cord-010119-t1x9gknd 328 32 systematically systematically RB cord-010119-t1x9gknd 328 33 effective effective JJ cord-010119-t1x9gknd 328 34 function function NN cord-010119-t1x9gknd 328 35 proteins protein NNS cord-010119-t1x9gknd 328 36 by by IN cord-010119-t1x9gknd 328 37 mTOR mTOR NNP cord-010119-t1x9gknd 328 38 - - HYPH cord-010119-t1x9gknd 328 39 S6 S6 NNP cord-010119-t1x9gknd 328 40 related relate VBN cord-010119-t1x9gknd 328 41 protein protein NN cord-010119-t1x9gknd 328 42 translation translation NN cord-010119-t1x9gknd 328 43 inhibition inhibition NN cord-010119-t1x9gknd 328 44 . . . cord-010119-t1x9gknd 329 1 Xiaoyun Xiaoyun NNP cord-010119-t1x9gknd 329 2 Fu Fu NNP cord-010119-t1x9gknd 329 3 * * NFP cord-010119-t1x9gknd 329 4 1,2 1,2 CD cord-010119-t1x9gknd 329 5 , , , cord-010119-t1x9gknd 329 6 Mikayla Mikayla NNP cord-010119-t1x9gknd 329 7 Anderson Anderson NNP cord-010119-t1x9gknd 329 8 1 1 CD cord-010119-t1x9gknd 329 9 and and CC cord-010119-t1x9gknd 329 10 James James NNP cord-010119-t1x9gknd 329 11 C C NNP cord-010119-t1x9gknd 329 12 Zimring Zimring NNP cord-010119-t1x9gknd 329 13 1,2 1,2 CD cord-010119-t1x9gknd 329 14 . . . cord-010119-t1x9gknd 330 1 1 1 CD cord-010119-t1x9gknd 330 2 BloodworksNW BloodworksNW NNP cord-010119-t1x9gknd 330 3 Research Research NNP cord-010119-t1x9gknd 330 4 Institute Institute NNP cord-010119-t1x9gknd 330 5 , , , cord-010119-t1x9gknd 330 6 2 2 CD cord-010119-t1x9gknd 330 7 University University NNP cord-010119-t1x9gknd 330 8 of of IN cord-010119-t1x9gknd 330 9 Washington Washington NNP cord-010119-t1x9gknd 330 10 School School NNP cord-010119-t1x9gknd 330 11 of of IN cord-010119-t1x9gknd 330 12 Medicine Medicine NNP cord-010119-t1x9gknd 330 13 Background Background NNP cord-010119-t1x9gknd 330 14 / / SYM cord-010119-t1x9gknd 330 15 Case Case NNP cord-010119-t1x9gknd 330 16 Studies Studies NNPS cord-010119-t1x9gknd 330 17 : : : cord-010119-t1x9gknd 330 18 Red red JJ cord-010119-t1x9gknd 330 19 blood blood NN cord-010119-t1x9gknd 330 20 cells cell NNS cord-010119-t1x9gknd 330 21 ( ( -LRB- cord-010119-t1x9gknd 330 22 RBCs rbc NNS cord-010119-t1x9gknd 330 23 ) ) -RRB- cord-010119-t1x9gknd 330 24 undergo undergo VBP cord-010119-t1x9gknd 330 25 many many JJ cord-010119-t1x9gknd 330 26 changes change NNS cord-010119-t1x9gknd 330 27 when when WRB cord-010119-t1x9gknd 330 28 stored store VBN cord-010119-t1x9gknd 330 29 under under IN cord-010119-t1x9gknd 330 30 blood blood NN cord-010119-t1x9gknd 330 31 banking banking NN cord-010119-t1x9gknd 330 32 conditions condition NNS cord-010119-t1x9gknd 330 33 , , , cord-010119-t1x9gknd 330 34 collectively collectively RB cord-010119-t1x9gknd 330 35 known know VBN cord-010119-t1x9gknd 330 36 as as IN cord-010119-t1x9gknd 330 37 the the DT cord-010119-t1x9gknd 330 38 storage storage NN cord-010119-t1x9gknd 330 39 lesion lesion NN cord-010119-t1x9gknd 330 40 . . . cord-010119-t1x9gknd 331 1 Bioactive bioactive JJ cord-010119-t1x9gknd 331 2 lipids lipid NNS cord-010119-t1x9gknd 331 3 generated generate VBN cord-010119-t1x9gknd 331 4 during during IN cord-010119-t1x9gknd 331 5 RBC RBC NNP cord-010119-t1x9gknd 331 6 storage storage NN cord-010119-t1x9gknd 331 7 have have VBP cord-010119-t1x9gknd 331 8 been be VBN cord-010119-t1x9gknd 331 9 implicated implicate VBN cord-010119-t1x9gknd 331 10 in in IN cord-010119-t1x9gknd 331 11 certain certain JJ cord-010119-t1x9gknd 331 12 adverse adverse JJ cord-010119-t1x9gknd 331 13 outcomes outcome NNS cord-010119-t1x9gknd 331 14 . . . cord-010119-t1x9gknd 332 1 Recently recently RB cord-010119-t1x9gknd 332 2 , , , cord-010119-t1x9gknd 332 3 we -PRON- PRP cord-010119-t1x9gknd 332 4 reported report VBD cord-010119-t1x9gknd 332 5 that that IN cord-010119-t1x9gknd 332 6 bioactive bioactive JJ cord-010119-t1x9gknd 332 7 lipids lipid NNS cord-010119-t1x9gknd 332 8 , , , cord-010119-t1x9gknd 332 9 especially especially RB cord-010119-t1x9gknd 332 10 polyunsaturated polyunsaturated JJ cord-010119-t1x9gknd 332 11 fatty fatty JJ cord-010119-t1x9gknd 332 12 acids acid NNS cord-010119-t1x9gknd 332 13 ( ( -LRB- cord-010119-t1x9gknd 332 14 PUFAs pufa NNS cord-010119-t1x9gknd 332 15 ) ) -RRB- cord-010119-t1x9gknd 332 16 and and CC cord-010119-t1x9gknd 332 17 their -PRON- PRP$ cord-010119-t1x9gknd 332 18 oxidized oxidize VBN cord-010119-t1x9gknd 332 19 products product NNS cord-010119-t1x9gknd 332 20 ( ( -LRB- cord-010119-t1x9gknd 332 21 oxylipins oxylipins NNP cord-010119-t1x9gknd 332 22 ) ) -RRB- cord-010119-t1x9gknd 332 23 accumulate accumulate VBP cord-010119-t1x9gknd 332 24 during during IN cord-010119-t1x9gknd 332 25 RBC RBC NNP cord-010119-t1x9gknd 332 26 storage storage NN cord-010119-t1x9gknd 332 27 despite despite IN cord-010119-t1x9gknd 332 28 leukoreduction leukoreduction NN cord-010119-t1x9gknd 332 29 . . . cord-010119-t1x9gknd 333 1 To to TO cord-010119-t1x9gknd 333 2 evaluate evaluate VB cord-010119-t1x9gknd 333 3 the the DT cord-010119-t1x9gknd 333 4 extent extent NN cord-010119-t1x9gknd 333 5 of of IN cord-010119-t1x9gknd 333 6 membrane membrane NN cord-010119-t1x9gknd 333 7 lipid lipid NN cord-010119-t1x9gknd 333 8 degradation degradation NN cord-010119-t1x9gknd 333 9 and and CC cord-010119-t1x9gknd 333 10 oxidation oxidation NN cord-010119-t1x9gknd 333 11 in in IN cord-010119-t1x9gknd 333 12 stored store VBN cord-010119-t1x9gknd 333 13 RBC RBC NNP cord-010119-t1x9gknd 333 14 units unit NNS cord-010119-t1x9gknd 333 15 among among IN cord-010119-t1x9gknd 333 16 the the DT cord-010119-t1x9gknd 333 17 donor donor NN cord-010119-t1x9gknd 333 18 population population NN cord-010119-t1x9gknd 333 19 with with IN cord-010119-t1x9gknd 333 20 different different JJ cord-010119-t1x9gknd 333 21 blood blood NN cord-010119-t1x9gknd 333 22 groups group NNS cord-010119-t1x9gknd 333 23 , , , cord-010119-t1x9gknd 333 24 we -PRON- PRP cord-010119-t1x9gknd 333 25 quantified quantify VBD cord-010119-t1x9gknd 333 26 PUFAs pufa NNS cord-010119-t1x9gknd 333 27 and and CC cord-010119-t1x9gknd 333 28 lysophospholipids lysophospholipid NNS cord-010119-t1x9gknd 333 29 ( ( -LRB- cord-010119-t1x9gknd 333 30 LPLs LPLs NNP cord-010119-t1x9gknd 333 31 ) ) -RRB- cord-010119-t1x9gknd 333 32 in in IN cord-010119-t1x9gknd 333 33 405 405 CD cord-010119-t1x9gknd 333 34 leukoreduced leukoreduce VBN cord-010119-t1x9gknd 333 35 RBC RBC NNP cord-010119-t1x9gknd 333 36 units unit NNS cord-010119-t1x9gknd 333 37 . . . cord-010119-t1x9gknd 334 1 Study Study NNP cord-010119-t1x9gknd 334 2 Design Design NNP cord-010119-t1x9gknd 334 3 / / SYM cord-010119-t1x9gknd 334 4 Method method NN cord-010119-t1x9gknd 334 5 : : : cord-010119-t1x9gknd 334 6 RBC RBC NNP cord-010119-t1x9gknd 334 7 units unit NNS cord-010119-t1x9gknd 334 8 from from IN cord-010119-t1x9gknd 334 9 different different JJ cord-010119-t1x9gknd 334 10 donors donor NNS cord-010119-t1x9gknd 334 11 were be VBD cord-010119-t1x9gknd 334 12 acquired acquire VBN cord-010119-t1x9gknd 334 13 and and CC cord-010119-t1x9gknd 334 14 processed process VBN cord-010119-t1x9gknd 334 15 on on IN cord-010119-t1x9gknd 334 16 day day NN cord-010119-t1x9gknd 334 17 43 43 CD cord-010119-t1x9gknd 334 18 ( ( -LRB- cord-010119-t1x9gknd 334 19 one one CD cord-010119-t1x9gknd 334 20 day day NN cord-010119-t1x9gknd 334 21 past past IN cord-010119-t1x9gknd 334 22 their -PRON- PRP$ cord-010119-t1x9gknd 334 23 expiration expiration NN cord-010119-t1x9gknd 334 24 ) ) -RRB- cord-010119-t1x9gknd 334 25 . . . cord-010119-t1x9gknd 335 1 35 35 CD cord-010119-t1x9gknd 335 2 bioactive bioactive JJ cord-010119-t1x9gknd 335 3 lipids lipid NNS cord-010119-t1x9gknd 335 4 including include VBG cord-010119-t1x9gknd 335 5 10 10 CD cord-010119-t1x9gknd 335 6 common common JJ cord-010119-t1x9gknd 335 7 Fatty fatty JJ cord-010119-t1x9gknd 335 8 acids acid NNS cord-010119-t1x9gknd 335 9 , , , cord-010119-t1x9gknd 335 10 10 10 CD cord-010119-t1x9gknd 335 11 oxylipins oxylipin NNS cord-010119-t1x9gknd 335 12 , , , cord-010119-t1x9gknd 335 13 and and CC cord-010119-t1x9gknd 335 14 15 15 CD cord-010119-t1x9gknd 335 15 LPLs lpl NNS cord-010119-t1x9gknd 335 16 were be VBD cord-010119-t1x9gknd 335 17 analyzed analyze VBN cord-010119-t1x9gknd 335 18 by by IN cord-010119-t1x9gknd 335 19 liquid liquid JJ cord-010119-t1x9gknd 335 20 chromatography chromatography NN cord-010119-t1x9gknd 335 21 - - HYPH cord-010119-t1x9gknd 335 22 tandem tandem NN cord-010119-t1x9gknd 335 23 mass mass NN cord-010119-t1x9gknd 335 24 spectrometry spectrometry NN cord-010119-t1x9gknd 335 25 with with IN cord-010119-t1x9gknd 335 26 multiple multiple JJ cord-010119-t1x9gknd 335 27 reaction reaction NN cord-010119-t1x9gknd 335 28 monitoring monitoring NN cord-010119-t1x9gknd 335 29 ( ( -LRB- cord-010119-t1x9gknd 335 30 LC LC NNP cord-010119-t1x9gknd 335 31 - - HYPH cord-010119-t1x9gknd 335 32 MS MS NNP cord-010119-t1x9gknd 335 33 / / SYM cord-010119-t1x9gknd 335 34 MS MS NNP cord-010119-t1x9gknd 335 35 - - HYPH cord-010119-t1x9gknd 335 36 MRM MRM NNP cord-010119-t1x9gknd 335 37 ) ) -RRB- cord-010119-t1x9gknd 335 38 . . . cord-010119-t1x9gknd 336 1 Total total JJ cord-010119-t1x9gknd 336 2 fatty fatty JJ cord-010119-t1x9gknd 336 3 acid acid NN cord-010119-t1x9gknd 336 4 concentrations concentration NNS cord-010119-t1x9gknd 336 5 of of IN cord-010119-t1x9gknd 336 6 selected select VBN cord-010119-t1x9gknd 336 7 units unit NNS cord-010119-t1x9gknd 336 8 were be VBD cord-010119-t1x9gknd 336 9 also also RB cord-010119-t1x9gknd 336 10 analyzed analyze VBN cord-010119-t1x9gknd 336 11 . . . cord-010119-t1x9gknd 337 1 A a DT cord-010119-t1x9gknd 337 2 One one CD cord-010119-t1x9gknd 337 3 - - HYPH cord-010119-t1x9gknd 337 4 way way NN cord-010119-t1x9gknd 337 5 ANOVA anova NN cord-010119-t1x9gknd 337 6 test test NN cord-010119-t1x9gknd 337 7 was be VBD cord-010119-t1x9gknd 337 8 used use VBN cord-010119-t1x9gknd 337 9 to to TO cord-010119-t1x9gknd 337 10 determine determine VB cord-010119-t1x9gknd 337 11 significant significant JJ cord-010119-t1x9gknd 337 12 difference difference NN cord-010119-t1x9gknd 337 13 of of IN cord-010119-t1x9gknd 337 14 analytes analyte NNS cord-010119-t1x9gknd 337 15 amongst amongst IN cord-010119-t1x9gknd 337 16 the the DT cord-010119-t1x9gknd 337 17 different different JJ cord-010119-t1x9gknd 337 18 blood blood NN cord-010119-t1x9gknd 337 19 groups group NNS cord-010119-t1x9gknd 337 20 . . . cord-010119-t1x9gknd 338 1 Results/ Results/ . cord-010119-t1x9gknd 339 1 Finding find VBG cord-010119-t1x9gknd 340 1 : : : cord-010119-t1x9gknd 340 2 We -PRON- PRP cord-010119-t1x9gknd 340 3 observed observe VBD cord-010119-t1x9gknd 340 4 a a DT cord-010119-t1x9gknd 340 5 wide wide JJ cord-010119-t1x9gknd 340 6 distribution distribution NN cord-010119-t1x9gknd 340 7 in in IN cord-010119-t1x9gknd 340 8 concentration concentration NN cord-010119-t1x9gknd 340 9 of of IN cord-010119-t1x9gknd 340 10 major major JJ cord-010119-t1x9gknd 340 11 PUFAs pufa NNS cord-010119-t1x9gknd 340 12 in in IN cord-010119-t1x9gknd 340 13 405 405 CD cord-010119-t1x9gknd 340 14 stored store VBN cord-010119-t1x9gknd 340 15 RBC RBC NNP cord-010119-t1x9gknd 340 16 units unit NNS cord-010119-t1x9gknd 340 17 . . . cord-010119-t1x9gknd 341 1 For for IN cord-010119-t1x9gknd 341 2 example example NN cord-010119-t1x9gknd 341 3 , , , cord-010119-t1x9gknd 341 4 arachidonic arachidonic JJ cord-010119-t1x9gknd 341 5 acid acid NN cord-010119-t1x9gknd 341 6 ( ( -LRB- cord-010119-t1x9gknd 341 7 AA AA NNP cord-010119-t1x9gknd 341 8 ) ) -RRB- cord-010119-t1x9gknd 341 9 ranges range VBZ cord-010119-t1x9gknd 341 10 from from IN cord-010119-t1x9gknd 341 11 0.5 0.5 CD cord-010119-t1x9gknd 341 12 -10.7 -10.7 SYM cord-010119-t1x9gknd 341 13 mM mm NN cord-010119-t1x9gknd 341 14 , , , cord-010119-t1x9gknd 341 15 linoleic linoleic JJ cord-010119-t1x9gknd 341 16 acid acid NN cord-010119-t1x9gknd 341 17 ( ( -LRB- cord-010119-t1x9gknd 341 18 LA LA NNP cord-010119-t1x9gknd 341 19 ) ) -RRB- cord-010119-t1x9gknd 341 20 ( ( -LRB- cord-010119-t1x9gknd 341 21 1.4 1.4 CD cord-010119-t1x9gknd 341 22 - - SYM cord-010119-t1x9gknd 341 23 28 28 CD cord-010119-t1x9gknd 341 24 mM mm CD cord-010119-t1x9gknd 341 25 ) ) -RRB- cord-010119-t1x9gknd 341 26 , , , cord-010119-t1x9gknd 341 27 dihomo dihomo NNP cord-010119-t1x9gknd 341 28 - - HYPH cord-010119-t1x9gknd 341 29 c c NN cord-010119-t1x9gknd 341 30 - - HYPH cord-010119-t1x9gknd 341 31 linolenic linolenic NN cord-010119-t1x9gknd 341 32 acid acid NN cord-010119-t1x9gknd 341 33 ( ( -LRB- cord-010119-t1x9gknd 341 34 DGLA DGLA NNP cord-010119-t1x9gknd 341 35 ) ) -RRB- cord-010119-t1x9gknd 341 36 ( ( -LRB- cord-010119-t1x9gknd 341 37 0.1 0.1 CD cord-010119-t1x9gknd 341 38 - - SYM cord-010119-t1x9gknd 341 39 0.8 0.8 CD cord-010119-t1x9gknd 341 40 mM mm CD cord-010119-t1x9gknd 341 41 ) ) -RRB- cord-010119-t1x9gknd 341 42 , , , cord-010119-t1x9gknd 341 43 eicosapentaenoic eicosapentaenoic JJ cord-010119-t1x9gknd 341 44 acid acid NN cord-010119-t1x9gknd 341 45 ( ( -LRB- cord-010119-t1x9gknd 341 46 EPA EPA NNP cord-010119-t1x9gknd 341 47 ) ) -RRB- cord-010119-t1x9gknd 341 48 ( ( -LRB- cord-010119-t1x9gknd 341 49 0.03 0.03 CD cord-010119-t1x9gknd 341 50 - - SYM cord-010119-t1x9gknd 341 51 3.1 3.1 CD cord-010119-t1x9gknd 341 52 mM mm CD cord-010119-t1x9gknd 341 53 ) ) -RRB- cord-010119-t1x9gknd 341 54 , , , cord-010119-t1x9gknd 341 55 docosahexaenoic docosahexaenoic NNP cord-010119-t1x9gknd 341 56 acid acid NNP cord-010119-t1x9gknd 341 57 ( ( -LRB- cord-010119-t1x9gknd 341 58 DHA DHA NNP cord-010119-t1x9gknd 341 59 ) ) -RRB- cord-010119-t1x9gknd 341 60 ( ( -LRB- cord-010119-t1x9gknd 341 61 0.2 0.2 CD cord-010119-t1x9gknd 341 62 - - SYM cord-010119-t1x9gknd 341 63 3.0 3.0 CD cord-010119-t1x9gknd 341 64 mM mm CD cord-010119-t1x9gknd 341 65 ) ) -RRB- cord-010119-t1x9gknd 341 66 , , , cord-010119-t1x9gknd 341 67 and and CC cord-010119-t1x9gknd 341 68 alpha alpha NN cord-010119-t1x9gknd 341 69 - - HYPH cord-010119-t1x9gknd 341 70 linolenic linolenic JJ cord-010119-t1x9gknd 341 71 acid acid NN cord-010119-t1x9gknd 341 72 ( ( -LRB- cord-010119-t1x9gknd 341 73 ALA ALA NNP cord-010119-t1x9gknd 341 74 ) ) -RRB- cord-010119-t1x9gknd 341 75 ( ( -LRB- cord-010119-t1x9gknd 341 76 0.06 0.06 CD cord-010119-t1x9gknd 341 77 - - SYM cord-010119-t1x9gknd 341 78 2.3 2.3 CD cord-010119-t1x9gknd 341 79 mM mm CD cord-010119-t1x9gknd 341 80 ) ) -RRB- cord-010119-t1x9gknd 341 81 . . . cord-010119-t1x9gknd 342 1 Ten ten CD cord-010119-t1x9gknd 342 2 oxylipins oxylipin NNS cord-010119-t1x9gknd 342 3 including include VBG cord-010119-t1x9gknd 342 4 HETEs hete NNS cord-010119-t1x9gknd 342 5 , , , cord-010119-t1x9gknd 342 6 HODEs hode NNS cord-010119-t1x9gknd 342 7 , , , cord-010119-t1x9gknd 342 8 and and CC cord-010119-t1x9gknd 342 9 DiHOMEs DiHOMEs NNP cord-010119-t1x9gknd 342 10 , , , cord-010119-t1x9gknd 342 11 and and CC cord-010119-t1x9gknd 342 12 15 15 CD cord-010119-t1x9gknd 342 13 LPLs lpls NN cord-010119-t1x9gknd 342 14 including include VBG cord-010119-t1x9gknd 342 15 LPCs lpc NNS cord-010119-t1x9gknd 342 16 , , , cord-010119-t1x9gknd 342 17 LPSs lps NNS cord-010119-t1x9gknd 342 18 , , , cord-010119-t1x9gknd 342 19 and and CC cord-010119-t1x9gknd 342 20 LPEs LPEs NNP cord-010119-t1x9gknd 342 21 all all DT cord-010119-t1x9gknd 342 22 showed show VBD cord-010119-t1x9gknd 342 23 a a DT cord-010119-t1x9gknd 342 24 large large JJ cord-010119-t1x9gknd 342 25 variation variation NN cord-010119-t1x9gknd 342 26 in in IN cord-010119-t1x9gknd 342 27 concentration concentration NN cord-010119-t1x9gknd 342 28 among among IN cord-010119-t1x9gknd 342 29 donors donor NNS cord-010119-t1x9gknd 342 30 . . . cord-010119-t1x9gknd 343 1 Of of IN cord-010119-t1x9gknd 343 2 35 35 CD cord-010119-t1x9gknd 343 3 analytes analyte NNS cord-010119-t1x9gknd 343 4 quantified quantify VBN cord-010119-t1x9gknd 343 5 , , , cord-010119-t1x9gknd 343 6 25 25 CD cord-010119-t1x9gknd 343 7 showed show VBD cord-010119-t1x9gknd 343 8 a a DT cord-010119-t1x9gknd 343 9 significant significant JJ cord-010119-t1x9gknd 343 10 difference difference NN cord-010119-t1x9gknd 343 11 in in IN cord-010119-t1x9gknd 343 12 concentration concentration NN cord-010119-t1x9gknd 343 13 among among IN cord-010119-t1x9gknd 343 14 different different JJ cord-010119-t1x9gknd 343 15 blood blood NN cord-010119-t1x9gknd 343 16 types type NNS cord-010119-t1x9gknd 343 17 by by IN cord-010119-t1x9gknd 343 18 one one CD cord-010119-t1x9gknd 343 19 - - HYPH cord-010119-t1x9gknd 343 20 way way NN cord-010119-t1x9gknd 343 21 ANOVA anova NN cord-010119-t1x9gknd 343 22 testing testing NN cord-010119-t1x9gknd 343 23 ( ( -LRB- cord-010119-t1x9gknd 343 24 FDR<0.05 FDR<0.05 NNP cord-010119-t1x9gknd 343 25 ) ) -RRB- cord-010119-t1x9gknd 343 26 . . . cord-010119-t1x9gknd 344 1 The the DT cord-010119-t1x9gknd 344 2 AB AB NNP cord-010119-t1x9gknd 344 3 Rh1 rh1 NN cord-010119-t1x9gknd 344 4 blood blood NN cord-010119-t1x9gknd 344 5 group group NN cord-010119-t1x9gknd 344 6 consistently consistently RB cord-010119-t1x9gknd 344 7 exhibited exhibit VBD cord-010119-t1x9gknd 344 8 the the DT cord-010119-t1x9gknd 344 9 lowest low JJS cord-010119-t1x9gknd 344 10 concentration concentration NN cord-010119-t1x9gknd 344 11 of of IN cord-010119-t1x9gknd 344 12 major major JJ cord-010119-t1x9gknd 344 13 PUFAs pufa NNS cord-010119-t1x9gknd 344 14 , , , cord-010119-t1x9gknd 344 15 while while IN cord-010119-t1x9gknd 344 16 the the DT cord-010119-t1x9gknd 344 17 O O NNP cord-010119-t1x9gknd 344 18 Rh Rh NNP cord-010119-t1x9gknd 344 19 - - HYPH cord-010119-t1x9gknd 344 20 blood blood NN cord-010119-t1x9gknd 344 21 group group NN cord-010119-t1x9gknd 344 22 showed show VBD cord-010119-t1x9gknd 344 23 the the DT cord-010119-t1x9gknd 344 24 highest high JJS cord-010119-t1x9gknd 344 25 , , , cord-010119-t1x9gknd 344 26 averaging average VBG cord-010119-t1x9gknd 344 27 a a DT cord-010119-t1x9gknd 344 28 two two CD cord-010119-t1x9gknd 344 29 - - HYPH cord-010119-t1x9gknd 344 30 fold fold JJ cord-010119-t1x9gknd 344 31 difference difference NN cord-010119-t1x9gknd 344 32 in in IN cord-010119-t1x9gknd 344 33 concentration concentration NN cord-010119-t1x9gknd 344 34 ( ( -LRB- cord-010119-t1x9gknd 344 35 O o UH cord-010119-t1x9gknd 344 36 Rh-/AB rh-/ab NN cord-010119-t1x9gknd 344 37 Rh1 rh1 NN cord-010119-t1x9gknd 344 38 ) ) -RRB- cord-010119-t1x9gknd 344 39 . . . cord-010119-t1x9gknd 345 1 The the DT cord-010119-t1x9gknd 345 2 fold fold JJ cord-010119-t1x9gknd 345 3 increase increase NN cord-010119-t1x9gknd 345 4 of of IN cord-010119-t1x9gknd 345 5 O o NN cord-010119-t1x9gknd 345 6 Rh-/O Rh-/O NNP cord-010119-t1x9gknd 345 7 Rh1 rh1 NN cord-010119-t1x9gknd 345 8 among among IN cord-010119-t1x9gknd 345 9 PUFAs pufa NNS cord-010119-t1x9gknd 345 10 ranges range VBZ cord-010119-t1x9gknd 345 11 from from IN cord-010119-t1x9gknd 345 12 1.3 1.3 CD cord-010119-t1x9gknd 345 13 to to IN cord-010119-t1x9gknd 345 14 2.1 2.1 CD cord-010119-t1x9gknd 345 15 , , , cord-010119-t1x9gknd 345 16 suggesting suggest VBG cord-010119-t1x9gknd 345 17 the the DT cord-010119-t1x9gknd 345 18 Rh Rh NNP cord-010119-t1x9gknd 345 19 blood blood NN cord-010119-t1x9gknd 345 20 group group NN cord-010119-t1x9gknd 345 21 , , , cord-010119-t1x9gknd 345 22 independent independent JJ cord-010119-t1x9gknd 345 23 of of IN cord-010119-t1x9gknd 345 24 the the DT cord-010119-t1x9gknd 345 25 ABO ABO NNP cord-010119-t1x9gknd 345 26 blood blood NN cord-010119-t1x9gknd 345 27 group group NN cord-010119-t1x9gknd 345 28 , , , cord-010119-t1x9gknd 345 29 correlates correlate VBZ cord-010119-t1x9gknd 345 30 with with IN cord-010119-t1x9gknd 345 31 donor donor NN cord-010119-t1x9gknd 345 32 to to IN cord-010119-t1x9gknd 345 33 donor donor NN cord-010119-t1x9gknd 345 34 variation variation NN cord-010119-t1x9gknd 345 35 in in IN cord-010119-t1x9gknd 345 36 lipid lipid NN cord-010119-t1x9gknd 345 37 metabolism metabolism NN cord-010119-t1x9gknd 345 38 . . . cord-010119-t1x9gknd 346 1 Conclusion conclusion NN cord-010119-t1x9gknd 346 2 : : : cord-010119-t1x9gknd 347 1 The the DT cord-010119-t1x9gknd 347 2 wide wide JJ cord-010119-t1x9gknd 347 3 distribution distribution NN cord-010119-t1x9gknd 347 4 in in IN cord-010119-t1x9gknd 347 5 the the DT cord-010119-t1x9gknd 347 6 concentration concentration NN cord-010119-t1x9gknd 347 7 of of IN cord-010119-t1x9gknd 347 8 bioactive bioactive JJ cord-010119-t1x9gknd 347 9 lipids lipid NNS cord-010119-t1x9gknd 347 10 among among IN cord-010119-t1x9gknd 347 11 405 405 CD cord-010119-t1x9gknd 347 12 stored store VBN cord-010119-t1x9gknd 347 13 RBC RBC NNP cord-010119-t1x9gknd 347 14 units unit NNS cord-010119-t1x9gknd 347 15 suggests suggest VBZ cord-010119-t1x9gknd 347 16 that that IN cord-010119-t1x9gknd 347 17 lipid lipid NN cord-010119-t1x9gknd 347 18 degradation degradation NN cord-010119-t1x9gknd 347 19 is be VBZ cord-010119-t1x9gknd 347 20 highly highly RB cord-010119-t1x9gknd 347 21 donor donor NN cord-010119-t1x9gknd 347 22 - - HYPH cord-010119-t1x9gknd 347 23 Background Background NNP cord-010119-t1x9gknd 347 24 / / SYM cord-010119-t1x9gknd 347 25 Case Case NNP cord-010119-t1x9gknd 347 26 Studies Studies NNPS cord-010119-t1x9gknd 347 27 : : : cord-010119-t1x9gknd 347 28 To to TO cord-010119-t1x9gknd 347 29 ensure ensure VB cord-010119-t1x9gknd 347 30 availability availability NN cord-010119-t1x9gknd 347 31 of of IN cord-010119-t1x9gknd 347 32 biological biological JJ cord-010119-t1x9gknd 347 33 products product NNS cord-010119-t1x9gknd 347 34 to to IN cord-010119-t1x9gknd 347 35 hospitals hospital NNS cord-010119-t1x9gknd 347 36 , , , cord-010119-t1x9gknd 347 37 blood blood NN cord-010119-t1x9gknd 347 38 banks bank NNS cord-010119-t1x9gknd 347 39 have have VBP cord-010119-t1x9gknd 347 40 developed develop VBN cord-010119-t1x9gknd 347 41 and and CC cord-010119-t1x9gknd 347 42 validated validate VBN cord-010119-t1x9gknd 347 43 multiple multiple JJ cord-010119-t1x9gknd 347 44 storage storage NN cord-010119-t1x9gknd 347 45 conditions condition NNS cord-010119-t1x9gknd 347 46 for for IN cord-010119-t1x9gknd 347 47 each each DT cord-010119-t1x9gknd 347 48 of of IN cord-010119-t1x9gknd 347 49 their -PRON- PRP$ cord-010119-t1x9gknd 347 50 products product NNS cord-010119-t1x9gknd 347 51 to to TO cord-010119-t1x9gknd 347 52 maximize maximize VB cord-010119-t1x9gknd 347 53 shelf shelf NN cord-010119-t1x9gknd 347 54 life life NN cord-010119-t1x9gknd 347 55 and and CC cord-010119-t1x9gknd 347 56 quality quality NN cord-010119-t1x9gknd 347 57 . . . cord-010119-t1x9gknd 348 1 In in IN cord-010119-t1x9gknd 348 2 the the DT cord-010119-t1x9gknd 348 3 case case NN cord-010119-t1x9gknd 348 4 of of IN cord-010119-t1x9gknd 348 5 labile labile JJ cord-010119-t1x9gknd 348 6 products product NNS cord-010119-t1x9gknd 348 7 , , , cord-010119-t1x9gknd 348 8 their -PRON- PRP$ cord-010119-t1x9gknd 348 9 metabolism metabolism NN cord-010119-t1x9gknd 348 10 is be VBZ cord-010119-t1x9gknd 348 11 known know VBN cord-010119-t1x9gknd 348 12 to to TO cord-010119-t1x9gknd 348 13 remain remain VB cord-010119-t1x9gknd 348 14 active active JJ cord-010119-t1x9gknd 348 15 during during IN cord-010119-t1x9gknd 348 16 storage storage NN cord-010119-t1x9gknd 348 17 , , , cord-010119-t1x9gknd 348 18 leading lead VBG cord-010119-t1x9gknd 348 19 to to IN cord-010119-t1x9gknd 348 20 storage storage NN cord-010119-t1x9gknd 348 21 lesions lesion NNS cord-010119-t1x9gknd 348 22 . . . cord-010119-t1x9gknd 349 1 microRNAs microRNAs NNP cord-010119-t1x9gknd 349 2 ( ( -LRB- cord-010119-t1x9gknd 349 3 miRNAs miRNAs NNP cord-010119-t1x9gknd 349 4 ) ) -RRB- cord-010119-t1x9gknd 349 5 levels level NNS cord-010119-t1x9gknd 349 6 are be VBP cord-010119-t1x9gknd 349 7 modulated modulate VBN cord-010119-t1x9gknd 349 8 by by IN cord-010119-t1x9gknd 349 9 these these DT cord-010119-t1x9gknd 349 10 storage storage NN cord-010119-t1x9gknd 349 11 - - HYPH cord-010119-t1x9gknd 349 12 related relate VBN cord-010119-t1x9gknd 349 13 damages damage NNS cord-010119-t1x9gknd 349 14 , , , cord-010119-t1x9gknd 349 15 which which WDT cord-010119-t1x9gknd 349 16 makes make VBZ cord-010119-t1x9gknd 349 17 miRNAs miRNAs NNP cord-010119-t1x9gknd 349 18 ideal ideal JJ cord-010119-t1x9gknd 349 19 candidates candidate NNS cord-010119-t1x9gknd 349 20 as as IN cord-010119-t1x9gknd 349 21 potential potential JJ cord-010119-t1x9gknd 349 22 biomarkers biomarker NNS cord-010119-t1x9gknd 349 23 of of IN cord-010119-t1x9gknd 349 24 quality quality NN cord-010119-t1x9gknd 349 25 monitoring monitoring NN cord-010119-t1x9gknd 349 26 . . . cord-010119-t1x9gknd 350 1 Lately lately RB cord-010119-t1x9gknd 350 2 , , , cord-010119-t1x9gknd 350 3 nanoparticles nanoparticle NNS cord-010119-t1x9gknd 350 4 have have VBP cord-010119-t1x9gknd 350 5 been be VBN cord-010119-t1x9gknd 350 6 widely widely RB cord-010119-t1x9gknd 350 7 studied study VBN cord-010119-t1x9gknd 350 8 and and CC cord-010119-t1x9gknd 350 9 used use VBN cord-010119-t1x9gknd 350 10 for for IN cord-010119-t1x9gknd 350 11 biosensing biosense VBG cord-010119-t1x9gknd 350 12 applications application NNS cord-010119-t1x9gknd 350 13 . . . cord-010119-t1x9gknd 351 1 The the DT cord-010119-t1x9gknd 351 2 objective objective NN cord-010119-t1x9gknd 351 3 of of IN cord-010119-t1x9gknd 351 4 this this DT cord-010119-t1x9gknd 351 5 work work NN cord-010119-t1x9gknd 351 6 is be VBZ cord-010119-t1x9gknd 351 7 to to TO cord-010119-t1x9gknd 351 8 develop develop VB cord-010119-t1x9gknd 351 9 biocompatible biocompatible JJ cord-010119-t1x9gknd 351 10 gold gold NN cord-010119-t1x9gknd 351 11 nanosensors nanosensor NNS cord-010119-t1x9gknd 351 12 for for IN cord-010119-t1x9gknd 351 13 sensitive sensitive JJ cord-010119-t1x9gknd 351 14 , , , cord-010119-t1x9gknd 351 15 selective selective JJ cord-010119-t1x9gknd 351 16 and and CC cord-010119-t1x9gknd 351 17 direct direct JJ cord-010119-t1x9gknd 351 18 detection detection NN cord-010119-t1x9gknd 351 19 of of IN cord-010119-t1x9gknd 351 20 biomarkers biomarker NNS cord-010119-t1x9gknd 351 21 to to TO cord-010119-t1x9gknd 351 22 characterize characterize VB cord-010119-t1x9gknd 351 23 and and CC cord-010119-t1x9gknd 351 24 assess assess VB cord-010119-t1x9gknd 351 25 the the DT cord-010119-t1x9gknd 351 26 quality quality NN cord-010119-t1x9gknd 351 27 of of IN cord-010119-t1x9gknd 351 28 blood blood NN cord-010119-t1x9gknd 351 29 products product NNS cord-010119-t1x9gknd 351 30 delivered deliver VBN cord-010119-t1x9gknd 351 31 to to IN cord-010119-t1x9gknd 351 32 hospitals hospital NNS cord-010119-t1x9gknd 351 33 . . . cord-010119-t1x9gknd 352 1 Study Study NNP cord-010119-t1x9gknd 352 2 Design Design NNP cord-010119-t1x9gknd 352 3 / / SYM cord-010119-t1x9gknd 352 4 Method method NN cord-010119-t1x9gknd 352 5 : : : cord-010119-t1x9gknd 352 6 Gold gold NN cord-010119-t1x9gknd 352 7 nanoparticles nanoparticle NNS cord-010119-t1x9gknd 352 8 ( ( -LRB- cord-010119-t1x9gknd 352 9 GNPs GNPs NNP cord-010119-t1x9gknd 352 10 ) ) -RRB- cord-010119-t1x9gknd 352 11 surrounded surround VBN cord-010119-t1x9gknd 352 12 by by IN cord-010119-t1x9gknd 352 13 a a DT cord-010119-t1x9gknd 352 14 fluorescent fluorescent JJ cord-010119-t1x9gknd 352 15 silica silica NN cord-010119-t1x9gknd 352 16 shell shell NN cord-010119-t1x9gknd 352 17 were be VBD cord-010119-t1x9gknd 352 18 prepared prepare VBN cord-010119-t1x9gknd 352 19 using use VBG cord-010119-t1x9gknd 352 20 a a DT cord-010119-t1x9gknd 352 21 wet wet JJ cord-010119-t1x9gknd 352 22 chemistry chemistry NN cord-010119-t1x9gknd 352 23 method method NN cord-010119-t1x9gknd 352 24 . . . cord-010119-t1x9gknd 353 1 miRNA-223 mirna-223 NN cord-010119-t1x9gknd 353 2 was be VBD cord-010119-t1x9gknd 353 3 chosen choose VBN cord-010119-t1x9gknd 353 4 as as IN cord-010119-t1x9gknd 353 5 a a DT cord-010119-t1x9gknd 353 6 potential potential JJ cord-010119-t1x9gknd 353 7 target target NN cord-010119-t1x9gknd 353 8 , , , cord-010119-t1x9gknd 353 9 since since IN cord-010119-t1x9gknd 353 10 it -PRON- PRP cord-010119-t1x9gknd 353 11 is be VBZ cord-010119-t1x9gknd 353 12 strongly strongly RB cord-010119-t1x9gknd 353 13 expressed express VBN cord-010119-t1x9gknd 353 14 in in IN cord-010119-t1x9gknd 353 15 platelet platelet NN cord-010119-t1x9gknd 353 16 concentrates concentrate NNS cord-010119-t1x9gknd 353 17 and and CC cord-010119-t1x9gknd 353 18 its -PRON- PRP$ cord-010119-t1x9gknd 353 19 concentration concentration NN cord-010119-t1x9gknd 353 20 fluctuates fluctuate VBZ cord-010119-t1x9gknd 353 21 according accord VBG cord-010119-t1x9gknd 353 22 to to IN cord-010119-t1x9gknd 353 23 storage storage NN cord-010119-t1x9gknd 353 24 lesions lesion NNS cord-010119-t1x9gknd 353 25 . . . cord-010119-t1x9gknd 354 1 Custom Custom NNP cord-010119-t1x9gknd 354 2 RNA RNA NNP cord-010119-t1x9gknd 354 3 and and CC cord-010119-t1x9gknd 354 4 DNA DNA NNP cord-010119-t1x9gknd 354 5 molecular molecular JJ cord-010119-t1x9gknd 354 6 beacons beacon NNS cord-010119-t1x9gknd 354 7 were be VBD cord-010119-t1x9gknd 354 8 designed design VBN cord-010119-t1x9gknd 354 9 and and CC cord-010119-t1x9gknd 354 10 used use VBN cord-010119-t1x9gknd 354 11 as as IN cord-010119-t1x9gknd 354 12 a a DT cord-010119-t1x9gknd 354 13 probe probe NN cord-010119-t1x9gknd 354 14 for for IN cord-010119-t1x9gknd 354 15 the the DT cord-010119-t1x9gknd 354 16 specific specific JJ cord-010119-t1x9gknd 354 17 detection detection NN cord-010119-t1x9gknd 354 18 of of IN cord-010119-t1x9gknd 354 19 miRNA-223 mirna-223 JJ cord-010119-t1x9gknd 354 20 targets target NNS cord-010119-t1x9gknd 354 21 in in IN cord-010119-t1x9gknd 354 22 PBS PBS NNP cord-010119-t1x9gknd 354 23 and and CC cord-010119-t1x9gknd 354 24 human human JJ cord-010119-t1x9gknd 354 25 plasma plasma NN cord-010119-t1x9gknd 354 26 . . . cord-010119-t1x9gknd 355 1 These these DT cord-010119-t1x9gknd 355 2 fluorescent fluorescent NN cord-010119-t1x9gknd 355 3 transducer transducer NN cord-010119-t1x9gknd 355 4 probes probe NNS cord-010119-t1x9gknd 355 5 were be VBD cord-010119-t1x9gknd 355 6 conjugated conjugate VBN cord-010119-t1x9gknd 355 7 at at IN cord-010119-t1x9gknd 355 8 the the DT cord-010119-t1x9gknd 355 9 surface surface NN cord-010119-t1x9gknd 355 10 of of IN cord-010119-t1x9gknd 355 11 fluorescent fluorescent JJ cord-010119-t1x9gknd 355 12 silica silica NN cord-010119-t1x9gknd 355 13 shell shell NN cord-010119-t1x9gknd 355 14 - - HYPH cord-010119-t1x9gknd 355 15 GNPs gnp NNS cord-010119-t1x9gknd 355 16 using use VBG cord-010119-t1x9gknd 355 17 an an DT cord-010119-t1x9gknd 355 18 EDC EDC NNP cord-010119-t1x9gknd 355 19 / / SYM cord-010119-t1x9gknd 355 20 NHS NHS NNP cord-010119-t1x9gknd 355 21 cross cross NN cord-010119-t1x9gknd 355 22 - - JJ cord-010119-t1x9gknd 355 23 linking link VBG cord-010119-t1x9gknd 355 24 reaction reaction NN cord-010119-t1x9gknd 355 25 . . . cord-010119-t1x9gknd 356 1 The the DT cord-010119-t1x9gknd 356 2 hybridization hybridization NN cord-010119-t1x9gknd 356 3 reaction reaction NN cord-010119-t1x9gknd 356 4 between between IN cord-010119-t1x9gknd 356 5 the the DT cord-010119-t1x9gknd 356 6 target target NN cord-010119-t1x9gknd 356 7 and and CC cord-010119-t1x9gknd 356 8 the the DT cord-010119-t1x9gknd 356 9 probe probe NN cord-010119-t1x9gknd 356 10 initiates initiate VBZ cord-010119-t1x9gknd 356 11 an an DT cord-010119-t1x9gknd 356 12 energy energy NN cord-010119-t1x9gknd 356 13 transfer transfer NN cord-010119-t1x9gknd 356 14 mechanism mechanism NN cord-010119-t1x9gknd 356 15 which which WDT cord-010119-t1x9gknd 356 16 can can MD cord-010119-t1x9gknd 356 17 be be VB cord-010119-t1x9gknd 356 18 recorded record VBN cord-010119-t1x9gknd 356 19 by by IN cord-010119-t1x9gknd 356 20 fluorescence fluorescence NN cord-010119-t1x9gknd 356 21 . . . cord-010119-t1x9gknd 357 1 Results/ Results/ . cord-010119-t1x9gknd 358 1 Finding finding NN cord-010119-t1x9gknd 358 2 : : : cord-010119-t1x9gknd 358 3 GNPs GNPs NNP cord-010119-t1x9gknd 358 4 ( ( -LRB- cord-010119-t1x9gknd 358 5 49 49 CD cord-010119-t1x9gknd 358 6 6 6 CD cord-010119-t1x9gknd 358 7 6 6 CD cord-010119-t1x9gknd 358 8 nm nm CD cord-010119-t1x9gknd 358 9 ) ) -RRB- cord-010119-t1x9gknd 358 10 surrounded surround VBN cord-010119-t1x9gknd 358 11 by by IN cord-010119-t1x9gknd 358 12 a a DT cord-010119-t1x9gknd 358 13 thick thick JJ cord-010119-t1x9gknd 358 14 fluorescent fluorescent JJ cord-010119-t1x9gknd 358 15 silica silica NN cord-010119-t1x9gknd 358 16 shell shell NN cord-010119-t1x9gknd 358 17 ( ( -LRB- cord-010119-t1x9gknd 358 18 22 22 CD cord-010119-t1x9gknd 358 19 6 6 CD cord-010119-t1x9gknd 358 20 2 2 CD cord-010119-t1x9gknd 358 21 nm nm CD cord-010119-t1x9gknd 358 22 ) ) -RRB- cord-010119-t1x9gknd 358 23 were be VBD cord-010119-t1x9gknd 358 24 prepared prepare VBN cord-010119-t1x9gknd 358 25 and and CC cord-010119-t1x9gknd 358 26 used use VBN cord-010119-t1x9gknd 358 27 as as IN cord-010119-t1x9gknd 358 28 nanosensors nanosensor NNS cord-010119-t1x9gknd 358 29 because because IN cord-010119-t1x9gknd 358 30 of of IN cord-010119-t1x9gknd 358 31 their -PRON- PRP$ cord-010119-t1x9gknd 358 32 optimal optimal JJ cord-010119-t1x9gknd 358 33 luminescence luminescence NN cord-010119-t1x9gknd 358 34 properties property NNS cord-010119-t1x9gknd 358 35 and and CC cord-010119-t1x9gknd 358 36 long long JJ cord-010119-t1x9gknd 358 37 - - HYPH cord-010119-t1x9gknd 358 38 term term NN cord-010119-t1x9gknd 358 39 stability stability NN cord-010119-t1x9gknd 358 40 . . . cord-010119-t1x9gknd 359 1 Conjugation conjugation NN cord-010119-t1x9gknd 359 2 of of IN cord-010119-t1x9gknd 359 3 the the DT cord-010119-t1x9gknd 359 4 probe probe NN cord-010119-t1x9gknd 359 5 onto onto IN cord-010119-t1x9gknd 359 6 the the DT cord-010119-t1x9gknd 359 7 nanoparticles nanoparticle NNS cord-010119-t1x9gknd 359 8 was be VBD cord-010119-t1x9gknd 359 9 confirmed confirm VBN cord-010119-t1x9gknd 359 10 by by IN cord-010119-t1x9gknd 359 11 fluorescence fluorescence NN cord-010119-t1x9gknd 359 12 spectroscopy spectroscopy NN cord-010119-t1x9gknd 359 13 and and CC cord-010119-t1x9gknd 359 14 microscopy microscopy NNS cord-010119-t1x9gknd 359 15 , , , cord-010119-t1x9gknd 359 16 as as RB cord-010119-t1x9gknd 359 17 well well RB cord-010119-t1x9gknd 359 18 as as IN cord-010119-t1x9gknd 359 19 nanoparticle nanoparticle NN cord-010119-t1x9gknd 359 20 tracking tracking NN cord-010119-t1x9gknd 359 21 analysis analysis NN cord-010119-t1x9gknd 359 22 . . . cord-010119-t1x9gknd 360 1 The the DT cord-010119-t1x9gknd 360 2 fluorescent fluorescent JJ cord-010119-t1x9gknd 360 3 response response NN cord-010119-t1x9gknd 360 4 of of IN cord-010119-t1x9gknd 360 5 the the DT cord-010119-t1x9gknd 360 6 molecular molecular JJ cord-010119-t1x9gknd 360 7 beacons beacon NNS cord-010119-t1x9gknd 360 8 was be VBD cord-010119-t1x9gknd 360 9 studied study VBN cord-010119-t1x9gknd 360 10 and and CC cord-010119-t1x9gknd 360 11 showed show VBD cord-010119-t1x9gknd 360 12 a a DT cord-010119-t1x9gknd 360 13 reproducible reproducible JJ cord-010119-t1x9gknd 360 14 and and CC cord-010119-t1x9gknd 360 15 linear linear JJ cord-010119-t1x9gknd 360 16 relationship relationship NN cord-010119-t1x9gknd 360 17 ( ( -LRB- cord-010119-t1x9gknd 360 18 R R NNP cord-010119-t1x9gknd 360 19 2 2 CD cord-010119-t1x9gknd 360 20 RNAprobe rnaprobe NN cord-010119-t1x9gknd 360 21 5 5 CD cord-010119-t1x9gknd 360 22 0.96 0.96 CD cord-010119-t1x9gknd 360 23 and and CC cord-010119-t1x9gknd 360 24 R r NN cord-010119-t1x9gknd 360 25 2 2 CD cord-010119-t1x9gknd 360 26 DNAprobe DNAprobe NNP cord-010119-t1x9gknd 360 27 5 5 CD cord-010119-t1x9gknd 360 28 0.98 0.98 CD cord-010119-t1x9gknd 360 29 ) ) -RRB- cord-010119-t1x9gknd 360 30 with with IN cord-010119-t1x9gknd 360 31 miRNA-223 mirna-223 JJ cord-010119-t1x9gknd 360 32 concentration concentration NN cord-010119-t1x9gknd 360 33 , , , cord-010119-t1x9gknd 360 34 down down RB cord-010119-t1x9gknd 360 35 to to IN cord-010119-t1x9gknd 360 36 a a DT cord-010119-t1x9gknd 360 37 10-nM 10-nm CD cord-010119-t1x9gknd 360 38 limit limit NN cord-010119-t1x9gknd 360 39 of of IN cord-010119-t1x9gknd 360 40 detection detection NN cord-010119-t1x9gknd 360 41 . . . cord-010119-t1x9gknd 361 1 Hybridization hybridization NN cord-010119-t1x9gknd 361 2 assays assay NNS cord-010119-t1x9gknd 361 3 in in IN cord-010119-t1x9gknd 361 4 1 1 CD cord-010119-t1x9gknd 361 5 % % NN cord-010119-t1x9gknd 361 6 human human JJ cord-010119-t1x9gknd 361 7 plasma plasma NN cord-010119-t1x9gknd 361 8 appear appear VBP cord-010119-t1x9gknd 361 9 to to TO cord-010119-t1x9gknd 361 10 demonstrate demonstrate VB cord-010119-t1x9gknd 361 11 denaturation denaturation NN cord-010119-t1x9gknd 361 12 of of IN cord-010119-t1x9gknd 361 13 RNA RNA NNP cord-010119-t1x9gknd 361 14 probes probe NNS cord-010119-t1x9gknd 361 15 and and CC cord-010119-t1x9gknd 361 16 targets target NNS cord-010119-t1x9gknd 361 17 . . . cord-010119-t1x9gknd 362 1 Conclusion conclusion NN cord-010119-t1x9gknd 362 2 : : : cord-010119-t1x9gknd 363 1 Biocompatible biocompatible JJ cord-010119-t1x9gknd 363 2 fluorescent fluorescent NN cord-010119-t1x9gknd 363 3 GNPs gnp NNS cord-010119-t1x9gknd 363 4 were be VBD cord-010119-t1x9gknd 363 5 prepared prepare VBN cord-010119-t1x9gknd 363 6 and and CC cord-010119-t1x9gknd 363 7 used use VBN cord-010119-t1x9gknd 363 8 as as IN cord-010119-t1x9gknd 363 9 tools tool NNS cord-010119-t1x9gknd 363 10 for for IN cord-010119-t1x9gknd 363 11 blood blood NN cord-010119-t1x9gknd 363 12 product product NN cord-010119-t1x9gknd 363 13 characterization characterization NN cord-010119-t1x9gknd 363 14 . . . cord-010119-t1x9gknd 364 1 The the DT cord-010119-t1x9gknd 364 2 conjugation conjugation NN cord-010119-t1x9gknd 364 3 of of IN cord-010119-t1x9gknd 364 4 a a DT cord-010119-t1x9gknd 364 5 molecular molecular JJ cord-010119-t1x9gknd 364 6 beacon beacon NN cord-010119-t1x9gknd 364 7 at at IN cord-010119-t1x9gknd 364 8 the the DT cord-010119-t1x9gknd 364 9 surface surface NN cord-010119-t1x9gknd 364 10 of of IN cord-010119-t1x9gknd 364 11 nanoparticles nanoparticle NNS cord-010119-t1x9gknd 364 12 was be VBD cord-010119-t1x9gknd 364 13 achieved achieve VBN cord-010119-t1x9gknd 364 14 and and CC cord-010119-t1x9gknd 364 15 characterized characterize VBN cord-010119-t1x9gknd 364 16 using use VBG cord-010119-t1x9gknd 364 17 spectroscopic spectroscopic JJ cord-010119-t1x9gknd 364 18 and and CC cord-010119-t1x9gknd 364 19 microscopic microscopic JJ cord-010119-t1x9gknd 364 20 techniques technique NNS cord-010119-t1x9gknd 364 21 . . . cord-010119-t1x9gknd 365 1 The the DT cord-010119-t1x9gknd 365 2 functionalization functionalization NN cord-010119-t1x9gknd 365 3 of of IN cord-010119-t1x9gknd 365 4 the the DT cord-010119-t1x9gknd 365 5 probe probe NN cord-010119-t1x9gknd 365 6 is be VBZ cord-010119-t1x9gknd 365 7 still still RB cord-010119-t1x9gknd 365 8 being be VBG cord-010119-t1x9gknd 365 9 optimized optimize VBN cord-010119-t1x9gknd 365 10 . . . cord-010119-t1x9gknd 366 1 The the DT cord-010119-t1x9gknd 366 2 fluorescence fluorescence NN cord-010119-t1x9gknd 366 3 response response NN cord-010119-t1x9gknd 366 4 of of IN cord-010119-t1x9gknd 366 5 the the DT cord-010119-t1x9gknd 366 6 molecular molecular JJ cord-010119-t1x9gknd 366 7 beacon beacon NN cord-010119-t1x9gknd 366 8 was be VBD cord-010119-t1x9gknd 366 9 characterized characterize VBN cord-010119-t1x9gknd 366 10 for for IN cord-010119-t1x9gknd 366 11 the the DT cord-010119-t1x9gknd 366 12 detection detection NN cord-010119-t1x9gknd 366 13 of of IN cord-010119-t1x9gknd 366 14 a a DT cord-010119-t1x9gknd 366 15 model model NN cord-010119-t1x9gknd 366 16 miRNA miRNA NNP cord-010119-t1x9gknd 366 17 target target NN cord-010119-t1x9gknd 366 18 in in IN cord-010119-t1x9gknd 366 19 PBS PBS NNP cord-010119-t1x9gknd 366 20 and and CC cord-010119-t1x9gknd 366 21 in in IN cord-010119-t1x9gknd 366 22 1 1 CD cord-010119-t1x9gknd 366 23 % % NN cord-010119-t1x9gknd 366 24 human human JJ cord-010119-t1x9gknd 366 25 plasma plasma NN cord-010119-t1x9gknd 366 26 . . . cord-010119-t1x9gknd 367 1 Energy energy NN cord-010119-t1x9gknd 367 2 Metabolism Metabolism NNP cord-010119-t1x9gknd 367 3 Profile Profile NNP cord-010119-t1x9gknd 367 4 of of IN cord-010119-t1x9gknd 367 5 Erythrocytes Erythrocytes NNPS cord-010119-t1x9gknd 367 6 during during IN cord-010119-t1x9gknd 367 7 Storage Storage NNP cord-010119-t1x9gknd 367 8 Suping Suping NNP cord-010119-t1x9gknd 367 9 Ren Ren NNP cord-010119-t1x9gknd 368 1 * * NFP cord-010119-t1x9gknd 368 2 , , , cord-010119-t1x9gknd 368 3 Qun Qun NNP cord-010119-t1x9gknd 368 4 Yu Yu NNP cord-010119-t1x9gknd 368 5 , , , cord-010119-t1x9gknd 368 6 Yanbing Yanbing NNP cord-010119-t1x9gknd 368 7 Wang Wang NNP cord-010119-t1x9gknd 368 8 , , , cord-010119-t1x9gknd 368 9 Changlan Changlan NNP cord-010119-t1x9gknd 368 10 Li Li NNP cord-010119-t1x9gknd 368 11 and and CC cord-010119-t1x9gknd 368 12 Yu Yu NNP cord-010119-t1x9gknd 368 13 Wang Wang NNP cord-010119-t1x9gknd 368 14 . . . cord-010119-t1x9gknd 369 1 Background Background NNP cord-010119-t1x9gknd 369 2 / / SYM cord-010119-t1x9gknd 369 3 Case Case NNP cord-010119-t1x9gknd 369 4 Studies Studies NNPS cord-010119-t1x9gknd 369 5 : : : cord-010119-t1x9gknd 370 1 The the DT cord-010119-t1x9gknd 370 2 moment moment NN cord-010119-t1x9gknd 370 3 the the DT cord-010119-t1x9gknd 370 4 mature mature JJ cord-010119-t1x9gknd 370 5 red red JJ cord-010119-t1x9gknd 370 6 blood blood NN cord-010119-t1x9gknd 370 7 cells cell NNS cord-010119-t1x9gknd 370 8 ( ( -LRB- cord-010119-t1x9gknd 370 9 RBCs rbc NNS cord-010119-t1x9gknd 370 10 ) ) -RRB- cord-010119-t1x9gknd 370 11 leave leave VBP cord-010119-t1x9gknd 370 12 the the DT cord-010119-t1x9gknd 370 13 bone bone NN cord-010119-t1x9gknd 370 14 marrow marrow NN cord-010119-t1x9gknd 370 15 , , , cord-010119-t1x9gknd 370 16 it -PRON- PRP cord-010119-t1x9gknd 370 17 is be VBZ cord-010119-t1x9gknd 370 18 optimally optimally RB cord-010119-t1x9gknd 370 19 adapted adapt VBN cord-010119-t1x9gknd 370 20 to to TO cord-010119-t1x9gknd 370 21 perform perform VB cord-010119-t1x9gknd 370 22 the the DT cord-010119-t1x9gknd 370 23 binding binding NN cord-010119-t1x9gknd 370 24 and and CC cord-010119-t1x9gknd 370 25 transport transport NN cord-010119-t1x9gknd 370 26 of of IN cord-010119-t1x9gknd 370 27 oxygen oxygen NN cord-010119-t1x9gknd 370 28 and and CC cord-010119-t1x9gknd 370 29 its -PRON- PRP$ cord-010119-t1x9gknd 370 30 delivery delivery NN cord-010119-t1x9gknd 370 31 to to IN cord-010119-t1x9gknd 370 32 all all DT cord-010119-t1x9gknd 370 33 tissues tissue NNS cord-010119-t1x9gknd 370 34 . . . cord-010119-t1x9gknd 371 1 Red red JJ cord-010119-t1x9gknd 371 2 blood blood NN cord-010119-t1x9gknd 371 3 cells cell NNS cord-010119-t1x9gknd 371 4 modulate modulate VBP cord-010119-t1x9gknd 371 5 oxygen oxygen NN cord-010119-t1x9gknd 371 6 transport transport NN cord-010119-t1x9gknd 371 7 , , , cord-010119-t1x9gknd 371 8 protect protect VB cord-010119-t1x9gknd 371 9 hemoglobin hemoglobin NN cord-010119-t1x9gknd 371 10 from from IN cord-010119-t1x9gknd 371 11 oxidant oxidant JJ cord-010119-t1x9gknd 371 12 - - HYPH cord-010119-t1x9gknd 371 13 induced induce VBN cord-010119-t1x9gknd 371 14 damage damage NN cord-010119-t1x9gknd 371 15 , , , cord-010119-t1x9gknd 371 16 and and CC cord-010119-t1x9gknd 371 17 maintain maintain VB cord-010119-t1x9gknd 371 18 the the DT cord-010119-t1x9gknd 371 19 osmotic osmotic JJ cord-010119-t1x9gknd 371 20 environment environment NN cord-010119-t1x9gknd 371 21 of of IN cord-010119-t1x9gknd 371 22 the the DT cord-010119-t1x9gknd 371 23 cell cell NN cord-010119-t1x9gknd 371 24 . . . cord-010119-t1x9gknd 372 1 Glycolysis glycolysis NN cord-010119-t1x9gknd 372 2 is be VBZ cord-010119-t1x9gknd 372 3 the the DT cord-010119-t1x9gknd 372 4 only only JJ cord-010119-t1x9gknd 372 5 energetic energetic JJ cord-010119-t1x9gknd 372 6 metabolic metabolic JJ cord-010119-t1x9gknd 372 7 pathway pathway NN cord-010119-t1x9gknd 372 8 for for IN cord-010119-t1x9gknd 372 9 mature mature JJ cord-010119-t1x9gknd 372 10 RBCs rbc NNS cord-010119-t1x9gknd 372 11 to to TO cord-010119-t1x9gknd 372 12 obtain obtain VB cord-010119-t1x9gknd 372 13 ATP ATP NNP cord-010119-t1x9gknd 372 14 which which WDT cord-010119-t1x9gknd 372 15 is be VBZ cord-010119-t1x9gknd 372 16 the the DT cord-010119-t1x9gknd 372 17 energy energy NN cord-010119-t1x9gknd 372 18 for for IN cord-010119-t1x9gknd 372 19 RBCs rbc NNS cord-010119-t1x9gknd 372 20 to to TO cord-010119-t1x9gknd 372 21 maintain maintain VB cord-010119-t1x9gknd 372 22 a a DT cord-010119-t1x9gknd 372 23 number number NN cord-010119-t1x9gknd 372 24 of of IN cord-010119-t1x9gknd 372 25 vital vital JJ cord-010119-t1x9gknd 372 26 cell cell NN cord-010119-t1x9gknd 372 27 functions function NNS cord-010119-t1x9gknd 372 28 . . . cord-010119-t1x9gknd 373 1 Generally generally RB cord-010119-t1x9gknd 373 2 , , , cord-010119-t1x9gknd 373 3 the the DT cord-010119-t1x9gknd 373 4 current current JJ cord-010119-t1x9gknd 373 5 methods method NNS cord-010119-t1x9gknd 373 6 used use VBN cord-010119-t1x9gknd 373 7 to to TO cord-010119-t1x9gknd 373 8 measure measure VB cord-010119-t1x9gknd 373 9 RBCs rbc NNS cord-010119-t1x9gknd 373 10 glycolysis glycolysis NN cord-010119-t1x9gknd 373 11 are be VBP cord-010119-t1x9gknd 373 12 not not RB cord-010119-t1x9gknd 373 13 in in IN cord-010119-t1x9gknd 373 14 living live VBG cord-010119-t1x9gknd 373 15 state state NN cord-010119-t1x9gknd 373 16 in in IN cord-010119-t1x9gknd 373 17 realtime realtime NN cord-010119-t1x9gknd 373 18 , , , cord-010119-t1x9gknd 373 19 or or CC cord-010119-t1x9gknd 373 20 are be VBP cord-010119-t1x9gknd 373 21 destructive destructive JJ cord-010119-t1x9gknd 373 22 to to IN cord-010119-t1x9gknd 373 23 cells cell NNS cord-010119-t1x9gknd 373 24 or or CC cord-010119-t1x9gknd 373 25 require require VB cord-010119-t1x9gknd 373 26 radioactivity radioactivity NN cord-010119-t1x9gknd 373 27 . . . cord-010119-t1x9gknd 374 1 XF xf NN cord-010119-t1x9gknd 374 2 technology technology NN cord-010119-t1x9gknd 374 3 can can MD cord-010119-t1x9gknd 374 4 be be VB cord-010119-t1x9gknd 374 5 applied apply VBN cord-010119-t1x9gknd 374 6 to to IN cord-010119-t1x9gknd 374 7 different different JJ cord-010119-t1x9gknd 374 8 types type NNS cord-010119-t1x9gknd 374 9 of of IN cord-010119-t1x9gknd 374 10 cells cell NNS cord-010119-t1x9gknd 374 11 , , , cord-010119-t1x9gknd 374 12 in in IN cord-010119-t1x9gknd 374 13 which which WDT cord-010119-t1x9gknd 374 14 the the DT cord-010119-t1x9gknd 374 15 red red JJ cord-010119-t1x9gknd 374 16 blood blood NN cord-010119-t1x9gknd 374 17 cells cell NNS cord-010119-t1x9gknd 374 18 are be VBP cord-010119-t1x9gknd 374 19 suspended suspend VBN cord-010119-t1x9gknd 374 20 and and CC cord-010119-t1x9gknd 374 21 the the DT cord-010119-t1x9gknd 374 22 cell cell NN cord-010119-t1x9gknd 374 23 shape shape NN cord-010119-t1x9gknd 374 24 and and CC cord-010119-t1x9gknd 374 25 size size NN cord-010119-t1x9gknd 374 26 are be VBP cord-010119-t1x9gknd 374 27 different different JJ cord-010119-t1x9gknd 374 28 from from IN cord-010119-t1x9gknd 374 29 other other JJ cord-010119-t1x9gknd 374 30 cells cell NNS cord-010119-t1x9gknd 374 31 , , , cord-010119-t1x9gknd 374 32 and and CC cord-010119-t1x9gknd 374 33 more more RBR cord-010119-t1x9gknd 374 34 importantly importantly RB cord-010119-t1x9gknd 374 35 , , , cord-010119-t1x9gknd 374 36 RBCs rbc NNS cord-010119-t1x9gknd 374 37 have have VBP cord-010119-t1x9gknd 374 38 no no DT cord-010119-t1x9gknd 374 39 nucleus nucleus NN cord-010119-t1x9gknd 374 40 , , , cord-010119-t1x9gknd 374 41 mitochondria mitochondrion NNS cord-010119-t1x9gknd 374 42 and and CC cord-010119-t1x9gknd 374 43 other other JJ cord-010119-t1x9gknd 374 44 organelles organelle NNS cord-010119-t1x9gknd 374 45 , , , cord-010119-t1x9gknd 374 46 so so IN cord-010119-t1x9gknd 374 47 application application NN cord-010119-t1x9gknd 374 48 of of IN cord-010119-t1x9gknd 374 49 the the DT cord-010119-t1x9gknd 374 50 XF XF NNP cord-010119-t1x9gknd 374 51 technology technology NN cord-010119-t1x9gknd 374 52 in in IN cord-010119-t1x9gknd 374 53 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 374 54 and and CC cord-010119-t1x9gknd 374 55 exploration exploration NN cord-010119-t1x9gknd 374 56 of of IN cord-010119-t1x9gknd 374 57 the the DT cord-010119-t1x9gknd 374 58 assay assay NN cord-010119-t1x9gknd 374 59 conditions condition NNS cord-010119-t1x9gknd 374 60 are be VBP cord-010119-t1x9gknd 374 61 necessary necessary JJ cord-010119-t1x9gknd 374 62 . . . cord-010119-t1x9gknd 375 1 6.7 6.7 CD cord-010119-t1x9gknd 375 2 6 6 CD cord-010119-t1x9gknd 375 3 0.0 0.0 CD cord-010119-t1x9gknd 375 4 a a DT cord-010119-t1x9gknd 375 5 6.9 6.9 CD cord-010119-t1x9gknd 375 6 6 6 CD cord-010119-t1x9gknd 375 7 0.0 0.0 CD cord-010119-t1x9gknd 375 8 6.7 6.7 CD cord-010119-t1x9gknd 375 9 6 6 CD cord-010119-t1x9gknd 375 10 0.0 0.0 CD cord-010119-t1x9gknd 376 1 a a DT cord-010119-t1x9gknd 376 2 6.6 6.6 CD cord-010119-t1x9gknd 376 3 6 6 CD cord-010119-t1x9gknd 376 4 0.0 0.0 CD cord-010119-t1x9gknd 376 5 6.7 6.7 CD cord-010119-t1x9gknd 376 6 6 6 CD cord-010119-t1x9gknd 376 7 0.0 0.0 CD cord-010119-t1x9gknd 377 1 a a DT cord-010119-t1x9gknd 377 2 6.9 6.9 CD cord-010119-t1x9gknd 377 3 6 6 CD cord-010119-t1x9gknd 377 4 0.0 0.0 CD cord-010119-t1x9gknd 377 5 Total total NN cord-010119-t1x9gknd 377 6 ATP ATP NNP cord-010119-t1x9gknd 377 7 , , , cord-010119-t1x9gknd 377 8 lM lM NNP cord-010119-t1x9gknd 377 9 / / SYM cord-010119-t1x9gknd 377 10 gHb gHb NNP cord-010119-t1x9gknd 377 11 7.6 7.6 CD cord-010119-t1x9gknd 377 12 6 6 CD cord-010119-t1x9gknd 377 13 0.3 0.3 CD cord-010119-t1x9gknd 377 14 a a DT cord-010119-t1x9gknd 377 15 5.2 5.2 CD cord-010119-t1x9gknd 377 16 6 6 CD cord-010119-t1x9gknd 377 17 0.3 0.3 CD cord-010119-t1x9gknd 377 18 7.3 7.3 CD cord-010119-t1x9gknd 377 19 6 6 CD cord-010119-t1x9gknd 377 20 0.2 0.2 CD cord-010119-t1x9gknd 377 21 a a DT cord-010119-t1x9gknd 377 22 5.5 5.5 CD cord-010119-t1x9gknd 377 23 6 6 CD cord-010119-t1x9gknd 377 24 0.3 0.3 CD cord-010119-t1x9gknd 377 25 7.3 7.3 CD cord-010119-t1x9gknd 377 26 6 6 CD cord-010119-t1x9gknd 377 27 0.4 0.4 CD cord-010119-t1x9gknd 377 28 a a DT cord-010119-t1x9gknd 377 29 4.9 4.9 CD cord-010119-t1x9gknd 377 30 6 6 CD cord-010119-t1x9gknd 377 31 0.5 0.5 CD cord-010119-t1x9gknd 377 32 Extracellular Extracellular NNP cord-010119-t1x9gknd 377 33 Lactate Lactate NNP cord-010119-t1x9gknd 377 34 , , , cord-010119-t1x9gknd 377 35 mM mm CD cord-010119-t1x9gknd 377 36 5 5 CD cord-010119-t1x9gknd 377 37 6 6 CD cord-010119-t1x9gknd 377 38 1 1 CD cord-010119-t1x9gknd 378 1 a a DT cord-010119-t1x9gknd 378 2 6 6 CD cord-010119-t1x9gknd 378 3 6 6 CD cord-010119-t1x9gknd 378 4 1 1 CD cord-010119-t1x9gknd 378 5 7 7 CD cord-010119-t1x9gknd 378 6 6 6 CD cord-010119-t1x9gknd 378 7 0 0 CD cord-010119-t1x9gknd 378 8 8 8 CD cord-010119-t1x9gknd 378 9 6 6 CD cord-010119-t1x9gknd 378 10 0 0 CD cord-010119-t1x9gknd 378 11 6 6 CD cord-010119-t1x9gknd 378 12 6 6 CD cord-010119-t1x9gknd 378 13 0 0 CD cord-010119-t1x9gknd 378 14 6 6 CD cord-010119-t1x9gknd 379 1 6 6 CD cord-010119-t1x9gknd 379 2 1 1 CD cord-010119-t1x9gknd 379 3 Extracellular Extracellular NNP cord-010119-t1x9gknd 379 4 Glucose Glucose NNP cord-010119-t1x9gknd 379 5 , , , cord-010119-t1x9gknd 379 6 mM mm CD cord-010119-t1x9gknd 379 7 32 32 CD cord-010119-t1x9gknd 379 8 6 6 CD cord-010119-t1x9gknd 379 9 1 1 CD cord-010119-t1x9gknd 380 1 a a LS cord-010119-t1x9gknd 381 1 50 50 CD cord-010119-t1x9gknd 381 2 6 6 CD cord-010119-t1x9gknd 381 3 3 3 CD cord-010119-t1x9gknd 381 4 2 2 CD cord-010119-t1x9gknd 381 5 9 9 CD cord-010119-t1x9gknd 381 6 6 6 CD cord-010119-t1x9gknd 381 7 1 1 CD cord-010119-t1x9gknd 382 1 a a LS cord-010119-t1x9gknd 383 1 38 38 CD cord-010119-t1x9gknd 383 2 6 6 CD cord-010119-t1x9gknd 383 3 1 1 CD cord-010119-t1x9gknd 383 4 2 2 CD cord-010119-t1x9gknd 383 5 5 5 CD cord-010119-t1x9gknd 383 6 6 6 CD cord-010119-t1x9gknd 383 7 0 0 CD cord-010119-t1x9gknd 383 8 a a DT cord-010119-t1x9gknd 383 9 28 28 CD cord-010119-t1x9gknd 383 10 6 6 CD cord-010119-t1x9gknd 383 11 1 1 CD cord-010119-t1x9gknd 383 12 Extracellular Extracellular NNP cord-010119-t1x9gknd 383 13 Na Na NNP cord-010119-t1x9gknd 383 14 1 1 CD cord-010119-t1x9gknd 383 15 , , , cord-010119-t1x9gknd 383 16 mM mm CD cord-010119-t1x9gknd 383 17 142 142 CD cord-010119-t1x9gknd 383 18 6 6 CD cord-010119-t1x9gknd 383 19 2 2 CD cord-010119-t1x9gknd 383 20 143 143 CD cord-010119-t1x9gknd 383 21 6 6 CD cord-010119-t1x9gknd 383 22 2 2 CD cord-010119-t1x9gknd 383 23 138 138 CD cord-010119-t1x9gknd 383 24 6 6 CD cord-010119-t1x9gknd 383 25 1 1 CD cord-010119-t1x9gknd 384 1 a a DT cord-010119-t1x9gknd 384 2 137 137 CD cord-010119-t1x9gknd 384 3 6 6 CD cord-010119-t1x9gknd 384 4 1 1 CD cord-010119-t1x9gknd 384 5 144 144 CD cord-010119-t1x9gknd 384 6 6 6 CD cord-010119-t1x9gknd 384 7 1 1 CD cord-010119-t1x9gknd 384 8 141 141 CD cord-010119-t1x9gknd 384 9 6 6 CD cord-010119-t1x9gknd 384 10 1 1 CD cord-010119-t1x9gknd 385 1 Extracellular Extracellular NNP cord-010119-t1x9gknd 385 2 K K NNP cord-010119-t1x9gknd 385 3 1 1 CD cord-010119-t1x9gknd 385 4 , , , cord-010119-t1x9gknd 385 5 mM mm CD cord-010119-t1x9gknd 385 6 1 1 CD cord-010119-t1x9gknd 385 7 6 6 CD cord-010119-t1x9gknd 385 8 0 0 CD cord-010119-t1x9gknd 385 9 a a DT cord-010119-t1x9gknd 385 10 4 4 CD cord-010119-t1x9gknd 385 11 6 6 CD cord-010119-t1x9gknd 385 12 0 0 CD cord-010119-t1x9gknd 385 13 1 1 CD cord-010119-t1x9gknd 385 14 6 6 CD cord-010119-t1x9gknd 385 15 0 0 CD cord-010119-t1x9gknd 386 1 a a DT cord-010119-t1x9gknd 386 2 5 5 CD cord-010119-t1x9gknd 386 3 6 6 CD cord-010119-t1x9gknd 386 4 0 0 CD cord-010119-t1x9gknd 386 5 1 1 CD cord-010119-t1x9gknd 386 6 6 6 CD cord-010119-t1x9gknd 386 7 0 0 CD cord-010119-t1x9gknd 386 8 a a DT cord-010119-t1x9gknd 386 9 4 4 CD cord-010119-t1x9gknd 386 10 6 6 CD cord-010119-t1x9gknd 386 11 0 0 CD cord-010119-t1x9gknd 386 12 a a DT cord-010119-t1x9gknd 386 13 p<0.05 p<0.05 NN cord-010119-t1x9gknd 386 14 , , . cord-010119-t1x9gknd 387 1 paired pair VBN cord-010119-t1x9gknd 387 2 t t NN cord-010119-t1x9gknd 387 3 - - HYPH cord-010119-t1x9gknd 387 4 test test NN cord-010119-t1x9gknd 387 5 b b . cord-010119-t1x9gknd 387 6 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 387 7 Blood blood NN cord-010119-t1x9gknd 387 8 System System NNP cord-010119-t1x9gknd 387 9 for for IN cord-010119-t1x9gknd 387 10 Red Red NNP cord-010119-t1x9gknd 387 11 Blood Blood NNP cord-010119-t1x9gknd 387 12 Cells Cells NNPS cord-010119-t1x9gknd 387 13 is be VBZ cord-010119-t1x9gknd 387 14 not not RB cord-010119-t1x9gknd 387 15 approved approve VBN cord-010119-t1x9gknd 387 16 for for IN cord-010119-t1x9gknd 387 17 commercial commercial JJ cord-010119-t1x9gknd 387 18 use use NN cord-010119-t1x9gknd 387 19 . . . cord-010119-t1x9gknd 388 1 c c NNP cord-010119-t1x9gknd 389 1 This this DT cord-010119-t1x9gknd 389 2 project project NN cord-010119-t1x9gknd 389 3 has have VBZ cord-010119-t1x9gknd 389 4 been be VBN cord-010119-t1x9gknd 389 5 funded fund VBN cord-010119-t1x9gknd 389 6 in in IN cord-010119-t1x9gknd 389 7 whole whole JJ cord-010119-t1x9gknd 389 8 or or CC cord-010119-t1x9gknd 389 9 in in IN cord-010119-t1x9gknd 389 10 part part NN cord-010119-t1x9gknd 389 11 with with IN cord-010119-t1x9gknd 389 12 Federal Federal NNP cord-010119-t1x9gknd 389 13 funds fund NNS cord-010119-t1x9gknd 389 14 from from IN cord-010119-t1x9gknd 389 15 the the DT cord-010119-t1x9gknd 389 16 DHHS DHHS NNP cord-010119-t1x9gknd 389 17 ; ; : cord-010119-t1x9gknd 389 18 ASPR ASPR NNP cord-010119-t1x9gknd 389 19 ; ; : cord-010119-t1x9gknd 389 20 BARDA BARDA NNP cord-010119-t1x9gknd 389 21 ; ; : cord-010119-t1x9gknd 390 1 Contract contract NN cord-010119-t1x9gknd 390 2 No no NN cord-010119-t1x9gknd 390 3 . . . cord-010119-t1x9gknd 391 1 HHSO100201600009C. HHSO100201600009C. NNP cord-010119-t1x9gknd 392 1 Background Background NNP cord-010119-t1x9gknd 392 2 / / SYM cord-010119-t1x9gknd 392 3 Case Case NNP cord-010119-t1x9gknd 392 4 Studies Studies NNPS cord-010119-t1x9gknd 392 5 : : : cord-010119-t1x9gknd 393 1 Pathogen pathogen NN cord-010119-t1x9gknd 393 2 inactivation inactivation NN cord-010119-t1x9gknd 393 3 methods method NNS cord-010119-t1x9gknd 393 4 for for IN cord-010119-t1x9gknd 393 5 platelet platelet NN cord-010119-t1x9gknd 393 6 concentrates concentrate NNS cord-010119-t1x9gknd 393 7 are be VBP cord-010119-t1x9gknd 393 8 increasingly increasingly RB cord-010119-t1x9gknd 393 9 being be VBG cord-010119-t1x9gknd 393 10 used use VBN cord-010119-t1x9gknd 393 11 in in IN cord-010119-t1x9gknd 393 12 blood blood NN cord-010119-t1x9gknd 393 13 banks bank NNS cord-010119-t1x9gknd 393 14 worldwide worldwide RB cord-010119-t1x9gknd 393 15 to to TO cord-010119-t1x9gknd 393 16 make make VB cord-010119-t1x9gknd 393 17 transfusion transfusion NN cord-010119-t1x9gknd 393 18 safer safe JJR cord-010119-t1x9gknd 393 19 . . . cord-010119-t1x9gknd 394 1 In in IN cord-010119-t1x9gknd 394 2 vitro vitro FW cord-010119-t1x9gknd 394 3 studies study NNS cord-010119-t1x9gknd 394 4 have have VBP cord-010119-t1x9gknd 394 5 demonstrated demonstrate VBN cord-010119-t1x9gknd 394 6 the the DT cord-010119-t1x9gknd 394 7 effects effect NNS cord-010119-t1x9gknd 394 8 of of IN cord-010119-t1x9gknd 394 9 pathogen pathogen NN cord-010119-t1x9gknd 394 10 inactivation inactivation NN cord-010119-t1x9gknd 394 11 on on IN cord-010119-t1x9gknd 394 12 storage storage NN cord-010119-t1x9gknd 394 13 lesion lesion NN cord-010119-t1x9gknd 394 14 , , , cord-010119-t1x9gknd 394 15 but but CC cord-010119-t1x9gknd 394 16 little little JJ cord-010119-t1x9gknd 394 17 routine routine JJ cord-010119-t1x9gknd 394 18 quality quality NN cord-010119-t1x9gknd 394 19 control control NN cord-010119-t1x9gknd 394 20 data datum NNS cord-010119-t1x9gknd 394 21 on on IN cord-010119-t1x9gknd 394 22 blood blood NN cord-010119-t1x9gknd 394 23 banking banking NN cord-010119-t1x9gknd 394 24 outcomes outcome NNS cord-010119-t1x9gknd 394 25 have have VBP cord-010119-t1x9gknd 394 26 been be VBN cord-010119-t1x9gknd 394 27 reported report VBN cord-010119-t1x9gknd 394 28 . . . cord-010119-t1x9gknd 395 1 Study Study NNP cord-010119-t1x9gknd 395 2 Design Design NNP cord-010119-t1x9gknd 395 3 / / SYM cord-010119-t1x9gknd 395 4 Method method NN cord-010119-t1x9gknd 395 5 : : : cord-010119-t1x9gknd 395 6 Swirling swirl VBG cord-010119-t1x9gknd 395 7 of of IN cord-010119-t1x9gknd 395 8 distributed distribute VBN cord-010119-t1x9gknd 395 9 products product NNS cord-010119-t1x9gknd 395 10 was be VBD cord-010119-t1x9gknd 395 11 monitored monitor VBN cord-010119-t1x9gknd 395 12 one one CD cord-010119-t1x9gknd 395 13 year year NN cord-010119-t1x9gknd 395 14 before before RB cord-010119-t1x9gknd 395 15 and and CC cord-010119-t1x9gknd 395 16 one one CD cord-010119-t1x9gknd 395 17 year year NN cord-010119-t1x9gknd 395 18 after after IN cord-010119-t1x9gknd 395 19 implementation implementation NN cord-010119-t1x9gknd 395 20 of of IN cord-010119-t1x9gknd 395 21 Intercept Intercept NNP cord-010119-t1x9gknd 395 22 pathogen pathogen NN cord-010119-t1x9gknd 395 23 inactivation inactivation NN cord-010119-t1x9gknd 395 24 . . . cord-010119-t1x9gknd 396 1 Metabolic metabolic JJ cord-010119-t1x9gknd 396 2 parameters parameter NNS cord-010119-t1x9gknd 396 3 like like IN cord-010119-t1x9gknd 396 4 pH ph NN cord-010119-t1x9gknd 396 5 , , , cord-010119-t1x9gknd 396 6 glucose glucose NN cord-010119-t1x9gknd 396 7 and and CC cord-010119-t1x9gknd 396 8 lactic lactic JJ cord-010119-t1x9gknd 396 9 acid acid NN cord-010119-t1x9gknd 396 10 were be VBD cord-010119-t1x9gknd 396 11 determined determine VBN cord-010119-t1x9gknd 396 12 in in IN cord-010119-t1x9gknd 396 13 a a DT cord-010119-t1x9gknd 396 14 random random JJ cord-010119-t1x9gknd 396 15 sample sample NN cord-010119-t1x9gknd 396 16 of of IN cord-010119-t1x9gknd 396 17 expired expired JJ cord-010119-t1x9gknd 396 18 pathogen pathogen NN cord-010119-t1x9gknd 396 19 inactivated inactivate VBN cord-010119-t1x9gknd 396 20 products product NNS cord-010119-t1x9gknd 396 21 . . . cord-010119-t1x9gknd 397 1 Furthermore furthermore RB cord-010119-t1x9gknd 397 2 , , , cord-010119-t1x9gknd 397 3 indicators indicator NNS cord-010119-t1x9gknd 397 4 of of IN cord-010119-t1x9gknd 397 5 platelet platelet NN cord-010119-t1x9gknd 397 6 storage storage NN cord-010119-t1x9gknd 397 7 lesion lesion NN cord-010119-t1x9gknd 397 8 were be VBD cord-010119-t1x9gknd 397 9 measured measure VBN cord-010119-t1x9gknd 397 10 in in IN cord-010119-t1x9gknd 397 11 apheresis apheresis NN cord-010119-t1x9gknd 397 12 concentrates concentrate VBZ cord-010119-t1x9gknd 397 13 with with IN cord-010119-t1x9gknd 397 14 premature premature JJ cord-010119-t1x9gknd 397 15 low low JJ cord-010119-t1x9gknd 397 16 swirling swirling NN cord-010119-t1x9gknd 397 17 and and CC cord-010119-t1x9gknd 397 18 compared compare VBN cord-010119-t1x9gknd 397 19 to to IN cord-010119-t1x9gknd 397 20 controls control NNS cord-010119-t1x9gknd 397 21 with with IN cord-010119-t1x9gknd 397 22 normal normal JJ cord-010119-t1x9gknd 397 23 swirling swirling NN cord-010119-t1x9gknd 397 24 . . . cord-010119-t1x9gknd 398 1 Results result NNS cord-010119-t1x9gknd 398 2 / / SYM cord-010119-t1x9gknd 398 3 Finding finding NN cord-010119-t1x9gknd 398 4 : : : cord-010119-t1x9gknd 399 1 In in IN cord-010119-t1x9gknd 399 2 an an DT cord-010119-t1x9gknd 399 3 experimental experimental JJ cord-010119-t1x9gknd 399 4 phase phase NN cord-010119-t1x9gknd 399 5 on on IN cord-010119-t1x9gknd 399 6 a a DT cord-010119-t1x9gknd 399 7 limited limited JJ cord-010119-t1x9gknd 399 8 number number NN cord-010119-t1x9gknd 399 9 of of IN cord-010119-t1x9gknd 399 10 products product NNS cord-010119-t1x9gknd 399 11 ( ( -LRB- cord-010119-t1x9gknd 399 12 n56 n56 NN cord-010119-t1x9gknd 399 13 ) ) -RRB- cord-010119-t1x9gknd 399 14 to to TO cord-010119-t1x9gknd 399 15 validate validate VB cord-010119-t1x9gknd 399 16 the the DT cord-010119-t1x9gknd 399 17 Intercept Intercept NNP cord-010119-t1x9gknd 399 18 pathogen pathogen NN cord-010119-t1x9gknd 399 19 inactivation inactivation NN cord-010119-t1x9gknd 399 20 method method NN cord-010119-t1x9gknd 399 21 , , , cord-010119-t1x9gknd 399 22 pH ph NN cord-010119-t1x9gknd 399 23 and and CC cord-010119-t1x9gknd 399 24 glucose glucose NN cord-010119-t1x9gknd 399 25 levels level NNS cord-010119-t1x9gknd 399 26 decreased decrease VBD cord-010119-t1x9gknd 399 27 faster fast RBR cord-010119-t1x9gknd 399 28 in in IN cord-010119-t1x9gknd 399 29 apheresis apheresis NN cord-010119-t1x9gknd 399 30 platelet platelet NN cord-010119-t1x9gknd 399 31 concentrates concentrate VBZ cord-010119-t1x9gknd 399 32 with with IN cord-010119-t1x9gknd 399 33 high high JJ cord-010119-t1x9gknd 399 34 platelet platelet NN cord-010119-t1x9gknd 399 35 content content NN cord-010119-t1x9gknd 399 36 than than IN cord-010119-t1x9gknd 399 37 with with IN cord-010119-t1x9gknd 399 38 low low JJ cord-010119-t1x9gknd 399 39 platelet platelet NN cord-010119-t1x9gknd 399 40 content content NN cord-010119-t1x9gknd 399 41 or or CC cord-010119-t1x9gknd 399 42 than than IN cord-010119-t1x9gknd 399 43 in in IN cord-010119-t1x9gknd 399 44 pooled pool VBN cord-010119-t1x9gknd 399 45 buffy buffy NNP cord-010119-t1x9gknd 399 46 coat coat NNP cord-010119-t1x9gknd 399 47 derived derive VBD cord-010119-t1x9gknd 399 48 products product NNS cord-010119-t1x9gknd 399 49 . . . cord-010119-t1x9gknd 400 1 Once once IN cord-010119-t1x9gknd 400 2 pathogen pathogen NN cord-010119-t1x9gknd 400 3 inactivation inactivation NN cord-010119-t1x9gknd 400 4 was be VBD cord-010119-t1x9gknd 400 5 implemented implement VBN cord-010119-t1x9gknd 400 6 , , , cord-010119-t1x9gknd 400 7 routine routine JJ cord-010119-t1x9gknd 400 8 products product NNS cord-010119-t1x9gknd 400 9 showed show VBD cord-010119-t1x9gknd 400 10 glucose glucose NN cord-010119-t1x9gknd 400 11 exhaustion exhaustion NN cord-010119-t1x9gknd 400 12 more more RBR cord-010119-t1x9gknd 400 13 often often RB cord-010119-t1x9gknd 400 14 when when WRB cord-010119-t1x9gknd 400 15 prepared prepare VBN cord-010119-t1x9gknd 400 16 by by IN cord-010119-t1x9gknd 400 17 apheresis apheresis NN cord-010119-t1x9gknd 400 18 compared compare VBN cord-010119-t1x9gknd 400 19 to to IN cord-010119-t1x9gknd 400 20 buffy buffy NNP cord-010119-t1x9gknd 400 21 coat coat NNP cord-010119-t1x9gknd 400 22 derived derive VBD cord-010119-t1x9gknd 400 23 platelet platelet NN cord-010119-t1x9gknd 400 24 concentrates concentrate VBZ cord-010119-t1x9gknd 400 25 despite despite IN cord-010119-t1x9gknd 400 26 more more JJR cord-010119-t1x9gknd 400 27 plasma plasma NN cord-010119-t1x9gknd 400 28 carryover carryover NN cord-010119-t1x9gknd 400 29 in in IN cord-010119-t1x9gknd 400 30 the the DT cord-010119-t1x9gknd 400 31 former former JJ cord-010119-t1x9gknd 400 32 . . . cord-010119-t1x9gknd 401 1 Furthermore furthermore RB cord-010119-t1x9gknd 401 2 , , , cord-010119-t1x9gknd 401 3 the the DT cord-010119-t1x9gknd 401 4 number number NN cord-010119-t1x9gknd 401 5 of of IN cord-010119-t1x9gknd 401 6 apheresis apheresis NN cord-010119-t1x9gknd 401 7 products product NNS cord-010119-t1x9gknd 401 8 with with IN cord-010119-t1x9gknd 401 9 premature premature JJ cord-010119-t1x9gknd 401 10 low low JJ cord-010119-t1x9gknd 401 11 swirling swirling NN cord-010119-t1x9gknd 401 12 increased increase VBD cord-010119-t1x9gknd 401 13 by by IN cord-010119-t1x9gknd 401 14 50 50 CD cord-010119-t1x9gknd 401 15 % % NN cord-010119-t1x9gknd 401 16 ( ( -LRB- cord-010119-t1x9gknd 401 17 63/12,492 63/12,492 NNP cord-010119-t1x9gknd 401 18 ) ) -RRB- cord-010119-t1x9gknd 401 19 compared compare VBN cord-010119-t1x9gknd 401 20 to to IN cord-010119-t1x9gknd 401 21 the the DT cord-010119-t1x9gknd 401 22 previous previous JJ cord-010119-t1x9gknd 401 23 year year NN cord-010119-t1x9gknd 401 24 without without IN cord-010119-t1x9gknd 401 25 pathogen pathogen NN cord-010119-t1x9gknd 401 26 inactivation inactivation NN cord-010119-t1x9gknd 401 27 ( ( -LRB- cord-010119-t1x9gknd 401 28 42/12 42/12 CD cord-010119-t1x9gknd 401 29 , , , cord-010119-t1x9gknd 401 30 931 931 CD cord-010119-t1x9gknd 401 31 , , , cord-010119-t1x9gknd 401 32 P50.030 p50.030 NN cord-010119-t1x9gknd 401 33 , , , cord-010119-t1x9gknd 401 34 Chisquare Chisquare NNP cord-010119-t1x9gknd 401 35 ) ) -RRB- cord-010119-t1x9gknd 401 36 . . . cord-010119-t1x9gknd 402 1 In in IN cord-010119-t1x9gknd 402 2 contrast contrast NN cord-010119-t1x9gknd 402 3 , , , cord-010119-t1x9gknd 402 4 the the DT cord-010119-t1x9gknd 402 5 incidence incidence NN cord-010119-t1x9gknd 402 6 of of IN cord-010119-t1x9gknd 402 7 premature premature JJ cord-010119-t1x9gknd 402 8 low low JJ cord-010119-t1x9gknd 402 9 swirling swirling NN cord-010119-t1x9gknd 402 10 in in IN cord-010119-t1x9gknd 402 11 platelet platelet NN cord-010119-t1x9gknd 402 12 concentrates concentrate NNS cord-010119-t1x9gknd 402 13 prepared prepare VBN cord-010119-t1x9gknd 402 14 by by IN cord-010119-t1x9gknd 402 15 the the DT cord-010119-t1x9gknd 402 16 buffy buffy NNP cord-010119-t1x9gknd 402 17 coat coat NNP cord-010119-t1x9gknd 402 18 method method NN cord-010119-t1x9gknd 402 19 decreased decrease VBD cord-010119-t1x9gknd 402 20 ( ( -LRB- cord-010119-t1x9gknd 402 21 2/15,286 2/15,286 CD cord-010119-t1x9gknd 402 22 vs vs IN cord-010119-t1x9gknd 402 23 10/ 10/ CD cord-010119-t1x9gknd 402 24 13,488 13,488 CD cord-010119-t1x9gknd 402 25 ) ) -RRB- cord-010119-t1x9gknd 402 26 . . . cord-010119-t1x9gknd 403 1 Of of IN cord-010119-t1x9gknd 403 2 note note NN cord-010119-t1x9gknd 403 3 , , , cord-010119-t1x9gknd 403 4 apheresis apheresis NN cord-010119-t1x9gknd 403 5 concentrates concentrate VBZ cord-010119-t1x9gknd 403 6 with with IN cord-010119-t1x9gknd 403 7 premature premature JJ cord-010119-t1x9gknd 403 8 low low JJ cord-010119-t1x9gknd 403 9 swirling swirling NN cord-010119-t1x9gknd 403 10 had have VBD cord-010119-t1x9gknd 403 11 a a DT cord-010119-t1x9gknd 403 12 significantly significantly RB cord-010119-t1x9gknd 403 13 higher high JJR cord-010119-t1x9gknd 403 14 median median JJ cord-010119-t1x9gknd 403 15 platelet platelet NN cord-010119-t1x9gknd 403 16 count count NN cord-010119-t1x9gknd 403 17 ( ( -LRB- cord-010119-t1x9gknd 403 18 5.0x10 5.0x10 CD cord-010119-t1x9gknd 403 19 11 11 CD cord-010119-t1x9gknd 403 20 ) ) -RRB- cord-010119-t1x9gknd 403 21 than than IN cord-010119-t1x9gknd 403 22 unaffected unaffected JJ cord-010119-t1x9gknd 403 23 controls control NNS cord-010119-t1x9gknd 403 24 ( ( -LRB- cord-010119-t1x9gknd 403 25 3.5x10 3.5x10 CD cord-010119-t1x9gknd 403 26 11 11 CD cord-010119-t1x9gknd 403 27 ) ) -RRB- cord-010119-t1x9gknd 403 28 and and CC cord-010119-t1x9gknd 403 29 showed show VBD cord-010119-t1x9gknd 403 30 signs sign NNS cord-010119-t1x9gknd 403 31 of of IN cord-010119-t1x9gknd 403 32 increased increase VBN cord-010119-t1x9gknd 403 33 storage storage NN cord-010119-t1x9gknd 403 34 lesion lesion NN cord-010119-t1x9gknd 403 35 compared compare VBN cord-010119-t1x9gknd 403 36 to to IN cord-010119-t1x9gknd 403 37 controls control NNS cord-010119-t1x9gknd 403 38 expiring expire VBG cord-010119-t1x9gknd 403 39 on on IN cord-010119-t1x9gknd 403 40 day day NN cord-010119-t1x9gknd 403 41 five five CD cord-010119-t1x9gknd 403 42 without without IN cord-010119-t1x9gknd 403 43 swirling swirl VBG cord-010119-t1x9gknd 403 44 defects defect NNS cord-010119-t1x9gknd 403 45 . . . cord-010119-t1x9gknd 404 1 These these DT cord-010119-t1x9gknd 404 2 signs sign NNS cord-010119-t1x9gknd 404 3 included include VBD cord-010119-t1x9gknd 404 4 lower low JJR cord-010119-t1x9gknd 404 5 pH ph NN cord-010119-t1x9gknd 404 6 , , , cord-010119-t1x9gknd 404 7 higher high JJR cord-010119-t1x9gknd 404 8 lactic lactic JJ cord-010119-t1x9gknd 404 9 acid acid NN cord-010119-t1x9gknd 404 10 concentration concentration NN cord-010119-t1x9gknd 404 11 , , , cord-010119-t1x9gknd 404 12 increased increase VBD cord-010119-t1x9gknd 404 13 mean mean JJ cord-010119-t1x9gknd 404 14 platelet platelet NN cord-010119-t1x9gknd 404 15 volume volume NN cord-010119-t1x9gknd 404 16 , , , cord-010119-t1x9gknd 404 17 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 404 18 exposure exposure NN cord-010119-t1x9gknd 404 19 and and CC cord-010119-t1x9gknd 404 20 alpha alpha NN cord-010119-t1x9gknd 404 21 - - HYPH cord-010119-t1x9gknd 404 22 degranulation degranulation NN cord-010119-t1x9gknd 404 23 . . . cord-010119-t1x9gknd 405 1 Conclusion conclusion NN cord-010119-t1x9gknd 405 2 : : : cord-010119-t1x9gknd 406 1 The the DT cord-010119-t1x9gknd 406 2 risk risk NN cord-010119-t1x9gknd 406 3 of of IN cord-010119-t1x9gknd 406 4 increased increase VBN cord-010119-t1x9gknd 406 5 storage storage NN cord-010119-t1x9gknd 406 6 lesion lesion NN cord-010119-t1x9gknd 406 7 rates rate NNS cord-010119-t1x9gknd 406 8 following follow VBG cord-010119-t1x9gknd 406 9 Intercept Intercept NNP cord-010119-t1x9gknd 406 10 pathogen pathogen NN cord-010119-t1x9gknd 406 11 inactivation inactivation NN cord-010119-t1x9gknd 406 12 is be VBZ cord-010119-t1x9gknd 406 13 higher high JJR cord-010119-t1x9gknd 406 14 for for IN cord-010119-t1x9gknd 406 15 apheresis apheresis NN cord-010119-t1x9gknd 406 16 than than IN cord-010119-t1x9gknd 406 17 for for IN cord-010119-t1x9gknd 406 18 buffy buffy NNP cord-010119-t1x9gknd 406 19 coat coat NNP cord-010119-t1x9gknd 406 20 derived derive VBD cord-010119-t1x9gknd 406 21 platelet platelet NN cord-010119-t1x9gknd 406 22 concentrates concentrate VBZ cord-010119-t1x9gknd 406 23 , , , cord-010119-t1x9gknd 406 24 especially especially RB cord-010119-t1x9gknd 406 25 when when WRB cord-010119-t1x9gknd 406 26 platelet platelet NN cord-010119-t1x9gknd 406 27 content content NN cord-010119-t1x9gknd 406 28 is be VBZ cord-010119-t1x9gknd 406 29 above above IN cord-010119-t1x9gknd 406 30 5.0x10 5.0x10 CD cord-010119-t1x9gknd 406 31 11 11 CD cord-010119-t1x9gknd 406 32 . . . cord-010119-t1x9gknd 407 1 In in IN cord-010119-t1x9gknd 407 2 Vitro Vitro NNP cord-010119-t1x9gknd 407 3 Quality Quality NNP cord-010119-t1x9gknd 407 4 of of IN cord-010119-t1x9gknd 407 5 Single Single NNP cord-010119-t1x9gknd 407 6 Dose Dose NNP cord-010119-t1x9gknd 407 7 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 407 8 / / SYM cord-010119-t1x9gknd 407 9 UVA UVA NNP cord-010119-t1x9gknd 408 1 Treated treated JJ cord-010119-t1x9gknd 408 2 Platelets platelet NNS cord-010119-t1x9gknd 408 3 in in IN cord-010119-t1x9gknd 408 4 35 35 CD cord-010119-t1x9gknd 408 5 % % NN cord-010119-t1x9gknd 409 1 Plasma/65 plasma/65 CD cord-010119-t1x9gknd 409 2 % % NN cord-010119-t1x9gknd 409 3 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 410 1 after after IN cord-010119-t1x9gknd 410 2 5 5 CD cord-010119-t1x9gknd 410 3 Days day NNS cord-010119-t1x9gknd 410 4 of of IN cord-010119-t1x9gknd 410 5 Storage Storage NNP cord-010119-t1x9gknd 410 6 Crystal Crystal NNP cord-010119-t1x9gknd 410 7 Stanley Stanley NNP cord-010119-t1x9gknd 410 8 1 1 CD cord-010119-t1x9gknd 410 9 , , , cord-010119-t1x9gknd 410 10 Marguerite Marguerite NNP cord-010119-t1x9gknd 410 11 Kelher Kelher NNP cord-010119-t1x9gknd 410 12 2 2 CD cord-010119-t1x9gknd 410 13 , , , cord-010119-t1x9gknd 410 14 Nero Nero NNP cord-010119-t1x9gknd 410 15 Evero Evero NNP cord-010119-t1x9gknd 410 16 1 1 CD cord-010119-t1x9gknd 410 17 , , , cord-010119-t1x9gknd 410 18 Melissa Melissa NNP cord-010119-t1x9gknd 410 19 VonGoetz VonGoetz NNP cord-010119-t1x9gknd 410 20 3 3 CD cord-010119-t1x9gknd 410 21 , , , cord-010119-t1x9gknd 410 22 Betsy Betsy NNP cord-010119-t1x9gknd 410 23 Donnelly Donnelly NNP cord-010119-t1x9gknd 410 24 3 3 CD cord-010119-t1x9gknd 410 25 and and CC cord-010119-t1x9gknd 410 26 Anna Anna NNP cord-010119-t1x9gknd 410 27 Erickson Erickson NNP cord-010119-t1x9gknd 410 28 * * NFP cord-010119-t1x9gknd 410 29 3 3 CD cord-010119-t1x9gknd 410 30 . . . cord-010119-t1x9gknd 411 1 1 1 CD cord-010119-t1x9gknd 411 2 Belle Belle NNP cord-010119-t1x9gknd 411 3 Bonfils Bonfils NNP cord-010119-t1x9gknd 411 4 Memorial Memorial NNP cord-010119-t1x9gknd 411 5 Blood Blood NNP cord-010119-t1x9gknd 411 6 Center Center NNP cord-010119-t1x9gknd 411 7 , , , cord-010119-t1x9gknd 411 8 2 2 CD cord-010119-t1x9gknd 411 9 University University NNP cord-010119-t1x9gknd 411 10 of of IN cord-010119-t1x9gknd 411 11 Colorado Colorado NNP cord-010119-t1x9gknd 411 12 , , , cord-010119-t1x9gknd 411 13 3 3 CD cord-010119-t1x9gknd 411 14 Cerus Cerus NNP cord-010119-t1x9gknd 411 15 Corporation Corporation NNP cord-010119-t1x9gknd 411 16 Background Background NNP cord-010119-t1x9gknd 411 17 / / SYM cord-010119-t1x9gknd 411 18 Case Case NNP cord-010119-t1x9gknd 411 19 Studies Studies NNPS cord-010119-t1x9gknd 411 20 : : : cord-010119-t1x9gknd 412 1 The the DT cord-010119-t1x9gknd 412 2 INTERCEPTV INTERCEPTV NNP cord-010119-t1x9gknd 412 3 R r NN cord-010119-t1x9gknd 412 4 Blood blood NN cord-010119-t1x9gknd 412 5 System system NN cord-010119-t1x9gknd 412 6 for for IN cord-010119-t1x9gknd 412 7 platelets platelet NNS cord-010119-t1x9gknd 412 8 is be VBZ cord-010119-t1x9gknd 412 9 FDA FDA NNP cord-010119-t1x9gknd 412 10 approved approve VBN cord-010119-t1x9gknd 412 11 for for IN cord-010119-t1x9gknd 412 12 the the DT cord-010119-t1x9gknd 412 13 ex ex FW cord-010119-t1x9gknd 412 14 vivo vivo NN cord-010119-t1x9gknd 412 15 preparation preparation NN cord-010119-t1x9gknd 412 16 of of IN cord-010119-t1x9gknd 412 17 pathogen pathogen NN cord-010119-t1x9gknd 412 18 - - HYPH cord-010119-t1x9gknd 412 19 reduced reduce VBN cord-010119-t1x9gknd 412 20 Amicus Amicus NNP cord-010119-t1x9gknd 412 21 O O NNP cord-010119-t1x9gknd 412 22 apheresis apheresis NN cord-010119-t1x9gknd 412 23 platelet platelet NN cord-010119-t1x9gknd 412 24 components component NNS cord-010119-t1x9gknd 412 25 ( ( -LRB- cord-010119-t1x9gknd 412 26 PC pc NN cord-010119-t1x9gknd 412 27 ) ) -RRB- cord-010119-t1x9gknd 412 28 in in IN cord-010119-t1x9gknd 412 29 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 412 30 to to TO cord-010119-t1x9gknd 412 31 reduce reduce VB cord-010119-t1x9gknd 412 32 the the DT cord-010119-t1x9gknd 412 33 risk risk NN cord-010119-t1x9gknd 412 34 of of IN cord-010119-t1x9gknd 412 35 TTI TTI NNP cord-010119-t1x9gknd 412 36 , , , cord-010119-t1x9gknd 412 37 including include VBG cord-010119-t1x9gknd 412 38 sepsis sepsis NN cord-010119-t1x9gknd 412 39 , , , cord-010119-t1x9gknd 412 40 and and CC cord-010119-t1x9gknd 412 41 to to TO cord-010119-t1x9gknd 412 42 potentially potentially RB cord-010119-t1x9gknd 412 43 reduce reduce VB cord-010119-t1x9gknd 412 44 the the DT cord-010119-t1x9gknd 412 45 risk risk NN cord-010119-t1x9gknd 412 46 of of IN cord-010119-t1x9gknd 412 47 transfusion transfusion NN cord-010119-t1x9gknd 412 48 - - HYPH cord-010119-t1x9gknd 412 49 associated associate VBN cord-010119-t1x9gknd 412 50 GVHD GVHD NNP cord-010119-t1x9gknd 412 51 . . . cord-010119-t1x9gknd 413 1 Registration registration NN cord-010119-t1x9gknd 413 2 studies study NNS cord-010119-t1x9gknd 413 3 ( ( -LRB- cord-010119-t1x9gknd 413 4 ClinicalTrials.gov ClinicalTrials.gov NNP cord-010119-t1x9gknd 413 5 NCT02298842 NCT02298842 NNP cord-010119-t1x9gknd 413 6 ) ) -RRB- cord-010119-t1x9gknd 413 7 are be VBP cord-010119-t1x9gknd 413 8 in in IN cord-010119-t1x9gknd 413 9 progress progress NN cord-010119-t1x9gknd 413 10 to to TO cord-010119-t1x9gknd 413 11 support support VB cord-010119-t1x9gknd 413 12 approval approval NN cord-010119-t1x9gknd 413 13 of of IN cord-010119-t1x9gknd 413 14 the the DT cord-010119-t1x9gknd 413 15 Trima Trima NNP cord-010119-t1x9gknd 413 16 O O NNP cord-010119-t1x9gknd 413 17 apheresis apheresis NN cord-010119-t1x9gknd 413 18 platform platform NN cord-010119-t1x9gknd 413 19 for for IN cord-010119-t1x9gknd 413 20 collection collection NN cord-010119-t1x9gknd 413 21 of of IN cord-010119-t1x9gknd 413 22 platelets platelet NNS cord-010119-t1x9gknd 413 23 components component NNS cord-010119-t1x9gknd 413 24 ( ( -LRB- cord-010119-t1x9gknd 413 25 PC pc NN cord-010119-t1x9gknd 413 26 ) ) -RRB- cord-010119-t1x9gknd 413 27 suspended suspend VBN cord-010119-t1x9gknd 413 28 in in IN cord-010119-t1x9gknd 413 29 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 413 30 and and CC cord-010119-t1x9gknd 413 31 plasma plasma NN cord-010119-t1x9gknd 413 32 . . . cord-010119-t1x9gknd 414 1 The the DT cord-010119-t1x9gknd 414 2 objective objective NN cord-010119-t1x9gknd 414 3 of of IN cord-010119-t1x9gknd 414 4 this this DT cord-010119-t1x9gknd 414 5 study study NN cord-010119-t1x9gknd 414 6 was be VBD cord-010119-t1x9gknd 414 7 to to TO cord-010119-t1x9gknd 414 8 evaluate evaluate VB cord-010119-t1x9gknd 414 9 in in IN cord-010119-t1x9gknd 414 10 vitro vitro FW cord-010119-t1x9gknd 414 11 function function NN cord-010119-t1x9gknd 414 12 of of IN cord-010119-t1x9gknd 414 13 platelets platelet NNS cord-010119-t1x9gknd 414 14 suspended suspend VBN cord-010119-t1x9gknd 414 15 in in IN cord-010119-t1x9gknd 414 16 35 35 CD cord-010119-t1x9gknd 414 17 % % NN cord-010119-t1x9gknd 414 18 plasma/65 plasma/65 NN cord-010119-t1x9gknd 414 19 % % NN cord-010119-t1x9gknd 414 20 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 414 21 , , , cord-010119-t1x9gknd 414 22 collected collect VBN cord-010119-t1x9gknd 414 23 using use VBG cord-010119-t1x9gknd 414 24 the the DT cord-010119-t1x9gknd 414 25 Trima Trima NNP cord-010119-t1x9gknd 414 26 platform platform NN cord-010119-t1x9gknd 414 27 , , , cord-010119-t1x9gknd 414 28 after after IN cord-010119-t1x9gknd 414 29 treatment treatment NN cord-010119-t1x9gknd 414 30 with with IN cord-010119-t1x9gknd 414 31 the the DT cord-010119-t1x9gknd 414 32 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 414 33 Blood blood NN cord-010119-t1x9gknd 414 34 System System NNP cord-010119-t1x9gknd 414 35 for for IN cord-010119-t1x9gknd 414 36 platelets platelet NNS cord-010119-t1x9gknd 414 37 . . . cord-010119-t1x9gknd 415 1 Study Study NNP cord-010119-t1x9gknd 415 2 Design Design NNP cord-010119-t1x9gknd 415 3 / / SYM cord-010119-t1x9gknd 415 4 Method method NN cord-010119-t1x9gknd 415 5 : : : cord-010119-t1x9gknd 416 1 Double double JJ cord-010119-t1x9gknd 416 2 dose dose JJ cord-010119-t1x9gknd 416 3 apheresis apheresis NN cord-010119-t1x9gknd 416 4 PC pc NN cord-010119-t1x9gknd 416 5 , , , cord-010119-t1x9gknd 416 6 7.5 7.5 CD cord-010119-t1x9gknd 416 7 6 6 CD cord-010119-t1x9gknd 416 8 0.6 0.6 CD cord-010119-t1x9gknd 416 9 310 310 CD cord-010119-t1x9gknd 416 10 11 11 CD cord-010119-t1x9gknd 416 11 platelets platelet NNS cord-010119-t1x9gknd 416 12 in in IN cord-010119-t1x9gknd 416 13 602 602 CD cord-010119-t1x9gknd 416 14 6 6 CD cord-010119-t1x9gknd 416 15 52 52 CD cord-010119-t1x9gknd 416 16 mL ml NN cord-010119-t1x9gknd 416 17 , , , cord-010119-t1x9gknd 416 18 were be VBD cord-010119-t1x9gknd 416 19 collected collect VBN cord-010119-t1x9gknd 416 20 on on IN cord-010119-t1x9gknd 416 21 the the DT cord-010119-t1x9gknd 416 22 Trima Trima NNP cord-010119-t1x9gknd 416 23 apheresis apheresis NN cord-010119-t1x9gknd 416 24 platform platform NN cord-010119-t1x9gknd 416 25 in in IN cord-010119-t1x9gknd 416 26 35 35 CD cord-010119-t1x9gknd 416 27 % % NN cord-010119-t1x9gknd 416 28 plasma/65 plasma/65 NN cord-010119-t1x9gknd 416 29 % % NN cord-010119-t1x9gknd 416 30 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 416 31 . . . cord-010119-t1x9gknd 417 1 A a DT cord-010119-t1x9gknd 417 2 sample sample NN cord-010119-t1x9gknd 417 3 was be VBD cord-010119-t1x9gknd 417 4 taken take VBN cord-010119-t1x9gknd 417 5 from from IN cord-010119-t1x9gknd 417 6 each each DT cord-010119-t1x9gknd 417 7 donation donation NN cord-010119-t1x9gknd 417 8 prior prior RB cord-010119-t1x9gknd 417 9 to to IN cord-010119-t1x9gknd 417 10 dividing divide VBG cord-010119-t1x9gknd 417 11 the the DT cord-010119-t1x9gknd 417 12 donation donation NN cord-010119-t1x9gknd 417 13 to to TO cord-010119-t1x9gknd 417 14 produce produce VB cord-010119-t1x9gknd 417 15 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 417 16 treated treat VBN cord-010119-t1x9gknd 417 17 apheresis apheresis NN cord-010119-t1x9gknd 417 18 PC pc NN cord-010119-t1x9gknd 417 19 ( ( -LRB- cord-010119-t1x9gknd 417 20 T T NNP cord-010119-t1x9gknd 417 21 ) ) -RRB- cord-010119-t1x9gknd 417 22 , , , cord-010119-t1x9gknd 417 23 using use VBG cord-010119-t1x9gknd 417 24 the the DT cord-010119-t1x9gknd 417 25 small small JJ cord-010119-t1x9gknd 417 26 volume volume NN cord-010119-t1x9gknd 417 27 ( ( -LRB- cord-010119-t1x9gknd 417 28 SV sv NN cord-010119-t1x9gknd 417 29 ) ) -RRB- cord-010119-t1x9gknd 417 30 set set NN cord-010119-t1x9gknd 417 31 , , , cord-010119-t1x9gknd 417 32 and and CC cord-010119-t1x9gknd 417 33 an an DT cord-010119-t1x9gknd 417 34 untreated untreated JJ cord-010119-t1x9gknd 417 35 control control NN cord-010119-t1x9gknd 417 36 PC pc NN cord-010119-t1x9gknd 417 37 ( ( -LRB- cord-010119-t1x9gknd 417 38 C C NNP cord-010119-t1x9gknd 417 39 ) ) -RRB- cord-010119-t1x9gknd 417 40 . . . cord-010119-t1x9gknd 418 1 Input input NN cord-010119-t1x9gknd 418 2 volumes volume NNS cord-010119-t1x9gknd 418 3 for for IN cord-010119-t1x9gknd 418 4 replicates replicate NNS cord-010119-t1x9gknd 418 5 , , , cord-010119-t1x9gknd 418 6 n56 n56 UH cord-010119-t1x9gknd 418 7 , , , cord-010119-t1x9gknd 418 8 were be VBD cord-010119-t1x9gknd 418 9 302 302 CD cord-010119-t1x9gknd 418 10 6 6 CD cord-010119-t1x9gknd 418 11 26mL 26ml CD cord-010119-t1x9gknd 418 12 ( ( -LRB- cord-010119-t1x9gknd 418 13 T T NNP cord-010119-t1x9gknd 418 14 ) ) -RRB- cord-010119-t1x9gknd 418 15 and and CC cord-010119-t1x9gknd 418 16 300 300 CD cord-010119-t1x9gknd 418 17 6 6 CD cord-010119-t1x9gknd 418 18 27mL 27ml CD cord-010119-t1x9gknd 418 19 ( ( -LRB- cord-010119-t1x9gknd 418 20 C C NNP cord-010119-t1x9gknd 418 21 ) ) -RRB- cord-010119-t1x9gknd 418 22 with with IN cord-010119-t1x9gknd 418 23 doses dose NNS cord-010119-t1x9gknd 418 24 of of IN cord-010119-t1x9gknd 418 25 3.8 3.8 CD cord-010119-t1x9gknd 418 26 6 6 CD cord-010119-t1x9gknd 418 27 0.3 0.3 CD cord-010119-t1x9gknd 418 28 3 3 CD cord-010119-t1x9gknd 418 29 10 10 CD cord-010119-t1x9gknd 418 30 11 11 CD cord-010119-t1x9gknd 418 31 ( ( -LRB- cord-010119-t1x9gknd 418 32 T T NNP cord-010119-t1x9gknd 418 33 ) ) -RRB- cord-010119-t1x9gknd 418 34 and and CC cord-010119-t1x9gknd 418 35 3.7 3.7 CD cord-010119-t1x9gknd 418 36 6 6 CD cord-010119-t1x9gknd 418 37 0.3 0.3 CD cord-010119-t1x9gknd 418 38 3 3 CD cord-010119-t1x9gknd 418 39 10 10 CD cord-010119-t1x9gknd 418 40 11 11 CD cord-010119-t1x9gknd 418 41 ( ( -LRB- cord-010119-t1x9gknd 418 42 C C NNP cord-010119-t1x9gknd 418 43 ) ) -RRB- cord-010119-t1x9gknd 418 44 . . . cord-010119-t1x9gknd 419 1 All all DT cord-010119-t1x9gknd 419 2 PC pc NN cord-010119-t1x9gknd 419 3 were be VBD cord-010119-t1x9gknd 419 4 stored store VBN cord-010119-t1x9gknd 419 5 under under IN cord-010119-t1x9gknd 419 6 the the DT cord-010119-t1x9gknd 419 7 same same JJ cord-010119-t1x9gknd 419 8 conditions condition NNS cord-010119-t1x9gknd 419 9 and and CC cord-010119-t1x9gknd 419 10 evaluated evaluate VBN cord-010119-t1x9gknd 419 11 on on IN cord-010119-t1x9gknd 419 12 Day Day NNP cord-010119-t1x9gknd 419 13 5 5 CD cord-010119-t1x9gknd 419 14 and and CC cord-010119-t1x9gknd 419 15 Day Day NNP cord-010119-t1x9gknd 419 16 7 7 CD cord-010119-t1x9gknd 419 17 for for IN cord-010119-t1x9gknd 419 18 physical physical JJ cord-010119-t1x9gknd 419 19 / / SYM cord-010119-t1x9gknd 419 20 metabolic metabolic JJ cord-010119-t1x9gknd 419 21 characteristics characteristic NNS cord-010119-t1x9gknd 419 22 . . . cord-010119-t1x9gknd 420 1 Results result NNS cord-010119-t1x9gknd 420 2 / / SYM cord-010119-t1x9gknd 420 3 Finding finding NN cord-010119-t1x9gknd 420 4 : : : cord-010119-t1x9gknd 420 5 On on IN cord-010119-t1x9gknd 420 6 Days day NNS cord-010119-t1x9gknd 420 7 5 5 CD cord-010119-t1x9gknd 420 8 and and CC cord-010119-t1x9gknd 420 9 7 7 CD cord-010119-t1x9gknd 420 10 all all DT cord-010119-t1x9gknd 420 11 T t NN cord-010119-t1x9gknd 420 12 and and CC cord-010119-t1x9gknd 420 13 C C NNP cord-010119-t1x9gknd 420 14 PC pc NN cord-010119-t1x9gknd 420 15 had have VBD cord-010119-t1x9gknd 420 16 pH228C pH228C NNS cord-010119-t1x9gknd 420 17 ! ! . cord-010119-t1x9gknd 420 18 6.2 6.2 CD cord-010119-t1x9gknd 420 19 . . . cord-010119-t1x9gknd 421 1 The the DT cord-010119-t1x9gknd 421 2 dose dose JJ cord-010119-t1x9gknd 421 3 recovery recovery NN cord-010119-t1x9gknd 421 4 for for IN cord-010119-t1x9gknd 421 5 T T NNP cord-010119-t1x9gknd 421 6 was be VBD cord-010119-t1x9gknd 421 7 87%63 87%63 CD cord-010119-t1x9gknd 421 8 % % NN cord-010119-t1x9gknd 421 9 . . . cord-010119-t1x9gknd 422 1 On on IN cord-010119-t1x9gknd 422 2 Day Day NNP cord-010119-t1x9gknd 422 3 5 5 CD cord-010119-t1x9gknd 422 4 , , , cord-010119-t1x9gknd 422 5 T T NNP cord-010119-t1x9gknd 422 6 had have VBD cord-010119-t1x9gknd 422 7 lower low JJR cord-010119-t1x9gknd 422 8 count count NN cord-010119-t1x9gknd 422 9 , , , cord-010119-t1x9gknd 422 10 volume volume NN cord-010119-t1x9gknd 422 11 , , , cord-010119-t1x9gknd 422 12 dose dose NN cord-010119-t1x9gknd 422 13 , , , cord-010119-t1x9gknd 422 14 bicarbonate bicarbonate NN cord-010119-t1x9gknd 422 15 and and CC cord-010119-t1x9gknd 422 16 glucose glucose NN cord-010119-t1x9gknd 422 17 compared compare VBN cord-010119-t1x9gknd 422 18 to to IN cord-010119-t1x9gknd 422 19 C c NN cord-010119-t1x9gknd 422 20 PC pc NN cord-010119-t1x9gknd 422 21 ; ; : cord-010119-t1x9gknd 422 22 however however RB cord-010119-t1x9gknd 422 23 , , , cord-010119-t1x9gknd 422 24 parameters parameter NNS cord-010119-t1x9gknd 422 25 predictive predictive JJ cord-010119-t1x9gknd 422 26 of of IN cord-010119-t1x9gknd 422 27 in in IN cord-010119-t1x9gknd 422 28 vivo vivo NN cord-010119-t1x9gknd 422 29 function function NN cord-010119-t1x9gknd 422 30 ( ( -LRB- cord-010119-t1x9gknd 422 31 ATP ATP NNP cord-010119-t1x9gknd 422 32 , , , cord-010119-t1x9gknd 422 33 morphology morphology NN cord-010119-t1x9gknd 422 34 score score NN cord-010119-t1x9gknd 422 35 , , , cord-010119-t1x9gknd 422 36 HSR HSR NNP cord-010119-t1x9gknd 422 37 , , , cord-010119-t1x9gknd 422 38 and and CC cord-010119-t1x9gknd 422 39 ESC ESC NNP cord-010119-t1x9gknd 422 40 ) ) -RRB- cord-010119-t1x9gknd 422 41 were be VBD cord-010119-t1x9gknd 422 42 equivalent equivalent JJ cord-010119-t1x9gknd 422 43 between between IN cord-010119-t1x9gknd 422 44 T T NNP cord-010119-t1x9gknd 422 45 and and CC cord-010119-t1x9gknd 422 46 C C NNP cord-010119-t1x9gknd 422 47 ( ( -LRB- cord-010119-t1x9gknd 422 48 Table Table NNP cord-010119-t1x9gknd 422 49 1 1 CD cord-010119-t1x9gknd 422 50 ) ) -RRB- cord-010119-t1x9gknd 422 51 . . . cord-010119-t1x9gknd 423 1 Conclusion conclusion NN cord-010119-t1x9gknd 423 2 : : : cord-010119-t1x9gknd 423 3 Trima Trima NNP cord-010119-t1x9gknd 423 4 PC pc NN cord-010119-t1x9gknd 423 5 in in IN cord-010119-t1x9gknd 423 6 35 35 CD cord-010119-t1x9gknd 423 7 % % NN cord-010119-t1x9gknd 424 1 plasma/65 plasma/65 NNP cord-010119-t1x9gknd 424 2 % % NN cord-010119-t1x9gknd 424 3 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 424 4 treated treat VBN cord-010119-t1x9gknd 424 5 with with IN cord-010119-t1x9gknd 424 6 the the DT cord-010119-t1x9gknd 424 7 INTER INTER NNP cord-010119-t1x9gknd 424 8 - - HYPH cord-010119-t1x9gknd 424 9 CEPT CEPT NNP cord-010119-t1x9gknd 424 10 Blood Blood NNP cord-010119-t1x9gknd 424 11 System System NNP cord-010119-t1x9gknd 424 12 for for IN cord-010119-t1x9gknd 424 13 platelets platelet NNS cord-010119-t1x9gknd 424 14 using use VBG cord-010119-t1x9gknd 424 15 the the DT cord-010119-t1x9gknd 424 16 SV SV NNP cord-010119-t1x9gknd 424 17 set set NN cord-010119-t1x9gknd 424 18 and and CC cord-010119-t1x9gknd 424 19 stored store VBN cord-010119-t1x9gknd 424 20 for for IN cord-010119-t1x9gknd 424 21 5 5 CD cord-010119-t1x9gknd 424 22 days day NNS cord-010119-t1x9gknd 424 23 retained retain VBN cord-010119-t1x9gknd 424 24 in in IN cord-010119-t1x9gknd 424 25 vitro vitro FW cord-010119-t1x9gknd 424 26 metabolic metabolic JJ cord-010119-t1x9gknd 424 27 and and CC cord-010119-t1x9gknd 424 28 functional functional JJ cord-010119-t1x9gknd 424 29 properties property NNS cord-010119-t1x9gknd 424 30 consistent consistent JJ cord-010119-t1x9gknd 424 31 with with IN cord-010119-t1x9gknd 424 32 in in IN cord-010119-t1x9gknd 424 33 vivo vivo NN cord-010119-t1x9gknd 424 34 functionality functionality NN cord-010119-t1x9gknd 424 35 . . . cord-010119-t1x9gknd 425 1 Induction induction NN cord-010119-t1x9gknd 425 2 of of IN cord-010119-t1x9gknd 425 3 Pluripotent Pluripotent NNP cord-010119-t1x9gknd 425 4 Stem Stem NNP cord-010119-t1x9gknd 425 5 Cell cell NN cord-010119-t1x9gknd 425 6 - - HYPH cord-010119-t1x9gknd 425 7 Derived derive VBN cord-010119-t1x9gknd 425 8 Cardiomyocyte Cardiomyocyte NNP cord-010119-t1x9gknd 425 9 Toxicity toxicity NN cord-010119-t1x9gknd 425 10 By by IN cord-010119-t1x9gknd 425 11 Supernatant Supernatant NNP cord-010119-t1x9gknd 425 12 of of IN cord-010119-t1x9gknd 425 13 Long Long NNP cord-010119-t1x9gknd 425 14 Term Term NNP cord-010119-t1x9gknd 425 15 - - HYPH cord-010119-t1x9gknd 425 16 Stored store VBN cord-010119-t1x9gknd 425 17 Red Red NNP cord-010119-t1x9gknd 425 18 Blood Blood NNP cord-010119-t1x9gknd 425 19 Cells cell NNS cord-010119-t1x9gknd 425 20 in in IN cord-010119-t1x9gknd 425 21 Vitro Vitro NNP cord-010119-t1x9gknd 425 22 Feng Feng NNP cord-010119-t1x9gknd 425 23 - - HYPH cord-010119-t1x9gknd 425 24 Yan Yan NNP cord-010119-t1x9gknd 425 25 Fan Fan NNP cord-010119-t1x9gknd 425 26 1,2 1,2 CD cord-010119-t1x9gknd 425 27 , , , cord-010119-t1x9gknd 425 28 Yang Yang NNP cord-010119-t1x9gknd 425 29 Yu Yu NNP cord-010119-t1x9gknd 425 30 1 1 CD cord-010119-t1x9gknd 425 31 , , , cord-010119-t1x9gknd 425 32 Li Li NNP cord-010119-t1x9gknd 425 33 - - HYPH cord-010119-t1x9gknd 425 34 Ping Ping NNP cord-010119-t1x9gknd 425 35 Sun Sun NNP cord-010119-t1x9gknd 425 36 1 1 CD cord-010119-t1x9gknd 425 37 , , , cord-010119-t1x9gknd 425 38 Shu Shu NNP cord-010119-t1x9gknd 425 39 - - HYPH cord-010119-t1x9gknd 425 40 Fang Fang NNP cord-010119-t1x9gknd 425 41 Wang Wang NNP cord-010119-t1x9gknd 425 42 1 1 CD cord-010119-t1x9gknd 425 43 , , , cord-010119-t1x9gknd 425 44 Rui Rui NNP cord-010119-t1x9gknd 425 45 Wang Wang NNP cord-010119-t1x9gknd 425 46 1 1 CD cord-010119-t1x9gknd 425 47 , , , cord-010119-t1x9gknd 425 48 Lei Lei NNP cord-010119-t1x9gknd 425 49 - - HYPH cord-010119-t1x9gknd 425 50 Ying Ying NNP cord-010119-t1x9gknd 425 51 Zhang Zhang NNP cord-010119-t1x9gknd 425 52 1 1 CD cord-010119-t1x9gknd 425 53 and and CC cord-010119-t1x9gknd 425 54 Deqing Deqing NNP cord-010119-t1x9gknd 425 55 Wang Wang NNP cord-010119-t1x9gknd 425 56 * * NFP cord-010119-t1x9gknd 425 57 1 1 CD cord-010119-t1x9gknd 425 58 . . . cord-010119-t1x9gknd 425 59 1 1 CD cord-010119-t1x9gknd 426 1 The the DT cord-010119-t1x9gknd 426 2 Department Department NNP cord-010119-t1x9gknd 426 3 of of IN cord-010119-t1x9gknd 426 4 Blood Blood NNP cord-010119-t1x9gknd 426 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 426 6 , , , cord-010119-t1x9gknd 426 7 The the DT cord-010119-t1x9gknd 426 8 PLA PLA NNP cord-010119-t1x9gknd 426 9 General General NNP cord-010119-t1x9gknd 426 10 Hospital Hospital NNP cord-010119-t1x9gknd 426 11 , , , cord-010119-t1x9gknd 426 12 2 2 CD cord-010119-t1x9gknd 427 1 The the DT cord-010119-t1x9gknd 427 2 Department Department NNP cord-010119-t1x9gknd 427 3 of of IN cord-010119-t1x9gknd 427 4 Blood Blood NNP cord-010119-t1x9gknd 427 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 427 6 , , , cord-010119-t1x9gknd 427 7 Air Air NNP cord-010119-t1x9gknd 427 8 Force Force NNP cord-010119-t1x9gknd 427 9 General General NNP cord-010119-t1x9gknd 427 10 Hospital Hospital NNP cord-010119-t1x9gknd 427 11 , , , cord-010119-t1x9gknd 428 1 PLA PLA NNP cord-010119-t1x9gknd 428 2 Background Background NNP cord-010119-t1x9gknd 428 3 / / SYM cord-010119-t1x9gknd 428 4 Case Case NNP cord-010119-t1x9gknd 428 5 Studies Studies NNPS cord-010119-t1x9gknd 428 6 : : : cord-010119-t1x9gknd 428 7 Recently recently RB cord-010119-t1x9gknd 428 8 , , , cord-010119-t1x9gknd 428 9 multi multi JJ cord-010119-t1x9gknd 428 10 researches research NNS cord-010119-t1x9gknd 428 11 have have VBP cord-010119-t1x9gknd 428 12 reported report VBN cord-010119-t1x9gknd 428 13 that that IN cord-010119-t1x9gknd 428 14 longer long JJR cord-010119-t1x9gknd 428 15 term term NN cord-010119-t1x9gknd 428 16 - - HYPH cord-010119-t1x9gknd 428 17 stored store VBN cord-010119-t1x9gknd 428 18 red red JJ cord-010119-t1x9gknd 428 19 blood blood NN cord-010119-t1x9gknd 428 20 cells(RBCs cells(rbc NNS cord-010119-t1x9gknd 428 21 ) ) -RRB- cord-010119-t1x9gknd 428 22 units unit NNS cord-010119-t1x9gknd 428 23 were be VBD cord-010119-t1x9gknd 428 24 associated associate VBN cord-010119-t1x9gknd 428 25 with with IN cord-010119-t1x9gknd 428 26 increased increase VBN cord-010119-t1x9gknd 428 27 risks risk NNS cord-010119-t1x9gknd 428 28 of of IN cord-010119-t1x9gknd 428 29 clinically clinically RB cord-010119-t1x9gknd 428 30 adverse adverse JJ cord-010119-t1x9gknd 428 31 events event NNS cord-010119-t1x9gknd 428 32 , , , cord-010119-t1x9gknd 428 33 especially especially RB cord-010119-t1x9gknd 428 34 in in IN cord-010119-t1x9gknd 428 35 critically critically RB cord-010119-t1x9gknd 428 36 ill ill JJ cord-010119-t1x9gknd 428 37 patients patient NNS cord-010119-t1x9gknd 428 38 . . . cord-010119-t1x9gknd 429 1 However however RB cord-010119-t1x9gknd 429 2 , , , cord-010119-t1x9gknd 429 3 other other JJ cord-010119-t1x9gknd 429 4 studies study NNS cord-010119-t1x9gknd 429 5 have have VBP cord-010119-t1x9gknd 429 6 concluded conclude VBN cord-010119-t1x9gknd 429 7 the the DT cord-010119-t1x9gknd 429 8 negative negative JJ cord-010119-t1x9gknd 429 9 results result NNS cord-010119-t1x9gknd 429 10 . . . cord-010119-t1x9gknd 430 1 Whether whether IN cord-010119-t1x9gknd 430 2 RBCs rbc NNS cord-010119-t1x9gknd 430 3 storage storage NN cord-010119-t1x9gknd 430 4 duration duration NN cord-010119-t1x9gknd 430 5 was be VBD cord-010119-t1x9gknd 430 6 associated associate VBN cord-010119-t1x9gknd 430 7 with with IN cord-010119-t1x9gknd 430 8 increased increase VBN cord-010119-t1x9gknd 430 9 risks risk NNS cord-010119-t1x9gknd 430 10 of of IN cord-010119-t1x9gknd 430 11 clinically clinically RB cord-010119-t1x9gknd 430 12 adverse adverse JJ cord-010119-t1x9gknd 430 13 events event NNS cord-010119-t1x9gknd 430 14 is be VBZ cord-010119-t1x9gknd 430 15 uncertain uncertain JJ cord-010119-t1x9gknd 430 16 and and CC cord-010119-t1x9gknd 430 17 had have VBD cord-010119-t1x9gknd 430 18 become become VBN cord-010119-t1x9gknd 430 19 a a DT cord-010119-t1x9gknd 430 20 popular popular JJ cord-010119-t1x9gknd 430 21 topic topic NN cord-010119-t1x9gknd 430 22 . . . cord-010119-t1x9gknd 431 1 To to TO cord-010119-t1x9gknd 431 2 study study VB cord-010119-t1x9gknd 431 3 the the DT cord-010119-t1x9gknd 431 4 adverse adverse JJ cord-010119-t1x9gknd 431 5 effects effect NNS cord-010119-t1x9gknd 431 6 of of IN cord-010119-t1x9gknd 431 7 longer long JJR cord-010119-t1x9gknd 431 8 term term NN cord-010119-t1x9gknd 431 9 - - HYPH cord-010119-t1x9gknd 431 10 stored store VBN cord-010119-t1x9gknd 431 11 RBCs rbc NNS cord-010119-t1x9gknd 431 12 directly directly RB cord-010119-t1x9gknd 431 13 , , , cord-010119-t1x9gknd 431 14 we -PRON- PRP cord-010119-t1x9gknd 431 15 aim aim VBP cord-010119-t1x9gknd 431 16 to to TO cord-010119-t1x9gknd 431 17 look look VB cord-010119-t1x9gknd 431 18 at at IN cord-010119-t1x9gknd 431 19 the the DT cord-010119-t1x9gknd 431 20 pluripotent pluripotent JJ cord-010119-t1x9gknd 431 21 stem stem NN cord-010119-t1x9gknd 431 22 cell cell NN cord-010119-t1x9gknd 431 23 - - HYPH cord-010119-t1x9gknd 431 24 derived derive VBN cord-010119-t1x9gknd 431 25 cardiomyocyte cardiomyocyte NN cord-010119-t1x9gknd 431 26 toxicity toxicity NN cord-010119-t1x9gknd 431 27 induced induce VBN cord-010119-t1x9gknd 431 28 by by IN cord-010119-t1x9gknd 431 29 supernatant supernatant NN cord-010119-t1x9gknd 431 30 of of IN cord-010119-t1x9gknd 431 31 suspended suspend VBN cord-010119-t1x9gknd 431 32 red red JJ cord-010119-t1x9gknd 431 33 blood blood NN cord-010119-t1x9gknd 431 34 cells(SSRBCs cells(ssrbcs NN cord-010119-t1x9gknd 431 35 ) ) -RRB- cord-010119-t1x9gknd 431 36 , , , cord-010119-t1x9gknd 431 37 and and CC cord-010119-t1x9gknd 431 38 study study VB cord-010119-t1x9gknd 431 39 the the DT cord-010119-t1x9gknd 431 40 possible possible JJ cord-010119-t1x9gknd 431 41 mechanism mechanism NN cord-010119-t1x9gknd 431 42 . . . cord-010119-t1x9gknd 432 1 Study Study NNP cord-010119-t1x9gknd 432 2 Design Design NNP cord-010119-t1x9gknd 432 3 / / SYM cord-010119-t1x9gknd 432 4 Methods method NNS cord-010119-t1x9gknd 432 5 : : : cord-010119-t1x9gknd 433 1 1 1 CD cord-010119-t1x9gknd 433 2 Five five CD cord-010119-t1x9gknd 433 3 doses dose NNS cord-010119-t1x9gknd 433 4 of of IN cord-010119-t1x9gknd 433 5 leuko leuko NN cord-010119-t1x9gknd 433 6 - - HYPH cord-010119-t1x9gknd 433 7 reduced reduce VBN cord-010119-t1x9gknd 433 8 RBCs rbc NNS cord-010119-t1x9gknd 433 9 were be VBD cord-010119-t1x9gknd 433 10 prepared prepare VBN cord-010119-t1x9gknd 433 11 , , , cord-010119-t1x9gknd 433 12 and and CC cord-010119-t1x9gknd 433 13 supernatant supernatant JJ cord-010119-t1x9gknd 433 14 was be VBD cord-010119-t1x9gknd 433 15 isolated isolate VBN cord-010119-t1x9gknd 433 16 by by IN cord-010119-t1x9gknd 433 17 centrifugation centrifugation NN cord-010119-t1x9gknd 433 18 on on IN cord-010119-t1x9gknd 433 19 d0 d0 NN cord-010119-t1x9gknd 433 20 , , , cord-010119-t1x9gknd 433 21 d14 d14 NNP cord-010119-t1x9gknd 433 22 and and CC cord-010119-t1x9gknd 433 23 d35 d35 NNP cord-010119-t1x9gknd 433 24 . . . cord-010119-t1x9gknd 434 1 We -PRON- PRP cord-010119-t1x9gknd 434 2 looked look VBD cord-010119-t1x9gknd 434 3 at at IN cord-010119-t1x9gknd 434 4 the the DT cord-010119-t1x9gknd 434 5 cardiotoxicity cardiotoxicity NN cord-010119-t1x9gknd 434 6 of of IN cord-010119-t1x9gknd 434 7 SSRBCs ssrbc NNS cord-010119-t1x9gknd 434 8 on on IN cord-010119-t1x9gknd 434 9 human human NN cord-010119-t1x9gknd 434 10 - - HYPH cord-010119-t1x9gknd 434 11 induced induce VBN cord-010119-t1x9gknd 434 12 pluripotent pluripotent JJ cord-010119-t1x9gknd 434 13 stem stem NN cord-010119-t1x9gknd 434 14 cell cell NN cord-010119-t1x9gknd 434 15 - - HYPH cord-010119-t1x9gknd 434 16 derived derive VBN cord-010119-t1x9gknd 434 17 cardiomyocytes cardiomyocyte NNS cord-010119-t1x9gknd 434 18 ( ( -LRB- cord-010119-t1x9gknd 434 19 hiPS hips NN cord-010119-t1x9gknd 434 20 - - HYPH cord-010119-t1x9gknd 434 21 CMs CMs NNP cord-010119-t1x9gknd 434 22 ) ) -RRB- cord-010119-t1x9gknd 434 23 . . . cord-010119-t1x9gknd 435 1 HiPS HiPS NNP cord-010119-t1x9gknd 435 2 - - HYPH cord-010119-t1x9gknd 435 3 CMs CMs NNP cord-010119-t1x9gknd 435 4 were be VBD cord-010119-t1x9gknd 435 5 treated treat VBN cord-010119-t1x9gknd 435 6 with with IN cord-010119-t1x9gknd 435 7 SSRBCs ssrbc NNS cord-010119-t1x9gknd 435 8 in in IN cord-010119-t1x9gknd 435 9 17 17 CD cord-010119-t1x9gknd 435 10 % % NN cord-010119-t1x9gknd 435 11 final final JJ cord-010119-t1x9gknd 435 12 volume volume NN cord-010119-t1x9gknd 435 13 simulating simulate VBG cord-010119-t1x9gknd 435 14 the the DT cord-010119-t1x9gknd 435 15 large large JJ cord-010119-t1x9gknd 435 16 volume volume NN cord-010119-t1x9gknd 435 17 blood blood NN cord-010119-t1x9gknd 435 18 transfusion transfusion NN cord-010119-t1x9gknd 435 19 . . . cord-010119-t1x9gknd 436 1 Using use VBG cord-010119-t1x9gknd 436 2 real real JJ cord-010119-t1x9gknd 436 3 - - HYPH cord-010119-t1x9gknd 436 4 time time NN cord-010119-t1x9gknd 436 5 cellular cellular JJ cord-010119-t1x9gknd 436 6 analysis analysis NN cord-010119-t1x9gknd 436 7 ( ( -LRB- cord-010119-t1x9gknd 436 8 RTCA RTCA NNP cord-010119-t1x9gknd 436 9 ) ) -RRB- cord-010119-t1x9gknd 436 10 technology technology NN cord-010119-t1x9gknd 437 1 the the DT cord-010119-t1x9gknd 437 2 beating beating NN cord-010119-t1x9gknd 437 3 of of IN cord-010119-t1x9gknd 437 4 hiPS hiPS NNP cord-010119-t1x9gknd 437 5 - - HYPH cord-010119-t1x9gknd 437 6 CMs CMs NNP cord-010119-t1x9gknd 437 7 was be VBD cord-010119-t1x9gknd 437 8 recorded record VBN cord-010119-t1x9gknd 437 9 in in IN cord-010119-t1x9gknd 437 10 real real JJ cord-010119-t1x9gknd 437 11 time time NN cord-010119-t1x9gknd 437 12 in in IN cord-010119-t1x9gknd 437 13 detail detail NN cord-010119-t1x9gknd 437 14 . . . cord-010119-t1x9gknd 438 1 2 2 LS cord-010119-t1x9gknd 438 2 Levels level NNS cord-010119-t1x9gknd 438 3 of of IN cord-010119-t1x9gknd 438 4 K k NN cord-010119-t1x9gknd 438 5 and and CC cord-010119-t1x9gknd 438 6 lactic lactic JJ cord-010119-t1x9gknd 438 7 acid acid NN cord-010119-t1x9gknd 438 8 ( ( -LRB- cord-010119-t1x9gknd 438 9 LA LA NNP cord-010119-t1x9gknd 438 10 ) ) -RRB- cord-010119-t1x9gknd 438 11 were be VBD cord-010119-t1x9gknd 438 12 tested test VBN cord-010119-t1x9gknd 438 13 using use VBG cord-010119-t1x9gknd 438 14 automatic automatic JJ cord-010119-t1x9gknd 438 15 biochemical biochemical JJ cord-010119-t1x9gknd 438 16 analyzer.3 analyzer.3 NN cord-010119-t1x9gknd 438 17 K K NNP cord-010119-t1x9gknd 438 18 and and CC cord-010119-t1x9gknd 438 19 LA LA NNP cord-010119-t1x9gknd 438 20 solution solution NN cord-010119-t1x9gknd 438 21 with with IN cord-010119-t1x9gknd 438 22 concentrations concentration NNS cord-010119-t1x9gknd 438 23 being be VBG cord-010119-t1x9gknd 438 24 consistent consistent JJ cord-010119-t1x9gknd 438 25 with with IN cord-010119-t1x9gknd 438 26 SSRBCs ssrbc NNS cord-010119-t1x9gknd 438 27 were be VBD cord-010119-t1x9gknd 438 28 prepared prepare VBN cord-010119-t1x9gknd 438 29 and and CC cord-010119-t1x9gknd 438 30 cocultured coculture VBN cord-010119-t1x9gknd 438 31 with with IN cord-010119-t1x9gknd 438 32 hiPS hiPS NNP cord-010119-t1x9gknd 438 33 - - HYPH cord-010119-t1x9gknd 438 34 CMs CMs NNP cord-010119-t1x9gknd 438 35 . . . cord-010119-t1x9gknd 439 1 We -PRON- PRP cord-010119-t1x9gknd 439 2 analyzed analyze VBD cord-010119-t1x9gknd 439 3 the the DT cord-010119-t1x9gknd 439 4 cardiotoxicity cardiotoxicity NN cord-010119-t1x9gknd 439 5 of of IN cord-010119-t1x9gknd 439 6 K K NNP cord-010119-t1x9gknd 439 7 and and CC cord-010119-t1x9gknd 439 8 LA LA NNP cord-010119-t1x9gknd 439 9 solution solution NN cord-010119-t1x9gknd 439 10 on on IN cord-010119-t1x9gknd 439 11 hiPS hiPS NNP cord-010119-t1x9gknd 439 12 - - HYPH cord-010119-t1x9gknd 439 13 CMs CMs NNP cord-010119-t1x9gknd 439 14 . . . cord-010119-t1x9gknd 440 1 4 4 LS cord-010119-t1x9gknd 441 1 Treated treat VBN cord-010119-t1x9gknd 441 2 hiPS hiPS NNP cord-010119-t1x9gknd 441 3 - - HYPH cord-010119-t1x9gknd 441 4 CMs CMs NNP cord-010119-t1x9gknd 441 5 with with IN cord-010119-t1x9gknd 441 6 d35 d35 NNP cord-010119-t1x9gknd 441 7 SSRBCs SSRBCs NNPS cord-010119-t1x9gknd 441 8 , , , cord-010119-t1x9gknd 441 9 d35 d35 NNP cord-010119-t1x9gknd 441 10 K K NNP cord-010119-t1x9gknd 441 11 and and CC cord-010119-t1x9gknd 441 12 cell cell NN cord-010119-t1x9gknd 441 13 culture culture NN cord-010119-t1x9gknd 441 14 media medium NNS cord-010119-t1x9gknd 441 15 for for IN cord-010119-t1x9gknd 441 16 48h 48h NNS cord-010119-t1x9gknd 441 17 . . . cord-010119-t1x9gknd 442 1 The the DT cord-010119-t1x9gknd 442 2 nuclear nuclear JJ cord-010119-t1x9gknd 442 3 shape shape NN cord-010119-t1x9gknd 442 4 and and CC cord-010119-t1x9gknd 442 5 integrity integrity NN cord-010119-t1x9gknd 442 6 of of IN cord-010119-t1x9gknd 442 7 filament filament NN cord-010119-t1x9gknd 442 8 and and CC cord-010119-t1x9gknd 442 9 sarcomere sarcomere NN cord-010119-t1x9gknd 442 10 was be VBD cord-010119-t1x9gknd 442 11 examined examine VBN cord-010119-t1x9gknd 442 12 by by IN cord-010119-t1x9gknd 442 13 immunofluorescence immunofluorescence NN cord-010119-t1x9gknd 442 14 . . . cord-010119-t1x9gknd 443 1 Total total JJ cord-010119-t1x9gknd 443 2 RNA RNA NNP cord-010119-t1x9gknd 443 3 of of IN cord-010119-t1x9gknd 443 4 hiPS hiPS NNP cord-010119-t1x9gknd 443 5 - - HYPH cord-010119-t1x9gknd 443 6 CMs CMs NNP cord-010119-t1x9gknd 443 7 was be VBD cord-010119-t1x9gknd 443 8 isolated isolate VBN cord-010119-t1x9gknd 443 9 and and CC cord-010119-t1x9gknd 443 10 mRNA mRNA NNP cord-010119-t1x9gknd 443 11 analysis analysis NN cord-010119-t1x9gknd 443 12 microarray microarray NN cord-010119-t1x9gknd 443 13 was be VBD cord-010119-t1x9gknd 443 14 implemented implement VBN cord-010119-t1x9gknd 443 15 . . . cord-010119-t1x9gknd 444 1 Screened screen VBN cord-010119-t1x9gknd 444 2 for for IN cord-010119-t1x9gknd 444 3 toxic toxic JJ cord-010119-t1x9gknd 444 4 effects effect NNS cord-010119-t1x9gknd 444 5 related relate VBN cord-010119-t1x9gknd 444 6 signaling signal VBG cord-010119-t1x9gknd 444 7 pathways pathway NNS cord-010119-t1x9gknd 444 8 through through IN cord-010119-t1x9gknd 444 9 bioinformatics bioinformatics NN cord-010119-t1x9gknd 444 10 analysis analysis NN cord-010119-t1x9gknd 444 11 . . . cord-010119-t1x9gknd 445 1 Results result NNS cord-010119-t1x9gknd 445 2 / / SYM cord-010119-t1x9gknd 445 3 Findings finding NNS cord-010119-t1x9gknd 445 4 : : : cord-010119-t1x9gknd 446 1 1 1 CD cord-010119-t1x9gknd 446 2 d0 d0 NNP cord-010119-t1x9gknd 446 3 SSRBCs SSRBCs NNPS cord-010119-t1x9gknd 446 4 had have VBD cord-010119-t1x9gknd 446 5 no no DT cord-010119-t1x9gknd 446 6 obvious obvious JJ cord-010119-t1x9gknd 446 7 influence influence NN cord-010119-t1x9gknd 446 8 on on IN cord-010119-t1x9gknd 446 9 beating beat VBG cord-010119-t1x9gknd 446 10 state state NN cord-010119-t1x9gknd 446 11 of of IN cord-010119-t1x9gknd 446 12 HiPS HiPS NNP cord-010119-t1x9gknd 446 13 - - HYPH cord-010119-t1x9gknd 446 14 CMs CMs NNP cord-010119-t1x9gknd 446 15 - - HYPH cord-010119-t1x9gknd 446 16 HiPS HiPS NNP cord-010119-t1x9gknd 446 17 - - HYPH cord-010119-t1x9gknd 446 18 CMs CMs NNP cord-010119-t1x9gknd 446 19 treated treat VBN cord-010119-t1x9gknd 446 20 with with IN cord-010119-t1x9gknd 446 21 d14 d14 NNP cord-010119-t1x9gknd 446 22 SSRBCs SSRBCs NNPS cord-010119-t1x9gknd 446 23 stop stop VBP cord-010119-t1x9gknd 446 24 beating beat VBG cord-010119-t1x9gknd 446 25 , , , cord-010119-t1x9gknd 446 26 but but CC cord-010119-t1x9gknd 446 27 beating beat VBG cord-010119-t1x9gknd 446 28 patterns pattern NNS cord-010119-t1x9gknd 446 29 restored restore VBN cord-010119-t1x9gknd 446 30 at at IN cord-010119-t1x9gknd 446 31 48h 48h NNS cord-010119-t1x9gknd 446 32 . . . cord-010119-t1x9gknd 447 1 HiPS HiPS NNP cord-010119-t1x9gknd 447 2 - - HYPH cord-010119-t1x9gknd 447 3 CMs CMs NNP cord-010119-t1x9gknd 447 4 treated treat VBN cord-010119-t1x9gknd 447 5 with with IN cord-010119-t1x9gknd 447 6 d35 d35 NNP cord-010119-t1x9gknd 447 7 SSRBCs SSRBCs NNPS cord-010119-t1x9gknd 447 8 stop stop VBP cord-010119-t1x9gknd 447 9 beating beat VBG cord-010119-t1x9gknd 447 10 , , , cord-010119-t1x9gknd 447 11 and and CC cord-010119-t1x9gknd 447 12 beating beat VBG cord-010119-t1x9gknd 447 13 patterns pattern NNS cord-010119-t1x9gknd 447 14 did do VBD cord-010119-t1x9gknd 447 15 not not RB cord-010119-t1x9gknd 447 16 restored restore VBN cord-010119-t1x9gknd 447 17 at at IN cord-010119-t1x9gknd 447 18 48h 48h NNS cord-010119-t1x9gknd 447 19 . . . cord-010119-t1x9gknd 448 1 2 2 LS cord-010119-t1x9gknd 448 2 Levels level NNS cord-010119-t1x9gknd 448 3 of of IN cord-010119-t1x9gknd 448 4 K K NNP cord-010119-t1x9gknd 448 5 and and CC cord-010119-t1x9gknd 448 6 LA LA NNP cord-010119-t1x9gknd 448 7 in in IN cord-010119-t1x9gknd 448 8 SSRBCs ssrbc NNS cord-010119-t1x9gknd 448 9 changed change VBD cord-010119-t1x9gknd 448 10 most most RBS cord-010119-t1x9gknd 448 11 obviously obviously RB cord-010119-t1x9gknd 448 12 . . . cord-010119-t1x9gknd 449 1 3 3 LS cord-010119-t1x9gknd 450 1 Only only RB cord-010119-t1x9gknd 450 2 d35 d35 NNP cord-010119-t1x9gknd 450 3 K K NNP cord-010119-t1x9gknd 450 4 solution solution NN cord-010119-t1x9gknd 450 5 made make VBD cord-010119-t1x9gknd 450 6 hiPS hiPS NNP cord-010119-t1x9gknd 450 7 - - HYPH cord-010119-t1x9gknd 450 8 CMs CMs NNP cord-010119-t1x9gknd 450 9 stop stop VB cord-010119-t1x9gknd 450 10 beating beat VBG cord-010119-t1x9gknd 450 11 and and CC cord-010119-t1x9gknd 450 12 can can MD cord-010119-t1x9gknd 450 13 restore restore VB cord-010119-t1x9gknd 450 14 in in IN cord-010119-t1x9gknd 450 15 48h 48h NNS cord-010119-t1x9gknd 450 16 ; ; : cord-010119-t1x9gknd 450 17 d0 d0 NNP cord-010119-t1x9gknd 450 18 K K NNP cord-010119-t1x9gknd 450 19 , , , cord-010119-t1x9gknd 450 20 d14 d14 NNP cord-010119-t1x9gknd 450 21 K K NNP cord-010119-t1x9gknd 450 22 and and CC cord-010119-t1x9gknd 450 23 LA LA NNP cord-010119-t1x9gknd 450 24 solution solution NN cord-010119-t1x9gknd 450 25 did do VBD cord-010119-t1x9gknd 450 26 not not RB cord-010119-t1x9gknd 450 27 influence influence VB cord-010119-t1x9gknd 450 28 the the DT cord-010119-t1x9gknd 450 29 beating beating NN cord-010119-t1x9gknd 450 30 pattern pattern NN cord-010119-t1x9gknd 450 31 in in IN cord-010119-t1x9gknd 450 32 At at IN cord-010119-t1x9gknd 450 33 the the DT cord-010119-t1x9gknd 450 34 end end NN cord-010119-t1x9gknd 450 35 of of IN cord-010119-t1x9gknd 450 36 the the DT cord-010119-t1x9gknd 450 37 treatment treatment NN cord-010119-t1x9gknd 450 38 for for IN cord-010119-t1x9gknd 450 39 24h 24h NNS cord-010119-t1x9gknd 450 40 , , , cord-010119-t1x9gknd 450 41 hiPS hiPS NNP cord-010119-t1x9gknd 450 42 - - HYPH cord-010119-t1x9gknd 450 43 CMs CMs NNP cord-010119-t1x9gknd 450 44 treated treat VBN cord-010119-t1x9gknd 450 45 with with IN cord-010119-t1x9gknd 451 1 d35 d35 NNP cord-010119-t1x9gknd 451 2 SSRBCs SSRBCs NNPS cord-010119-t1x9gknd 451 3 show show VBP cord-010119-t1x9gknd 451 4 obvious obvious JJ cord-010119-t1x9gknd 451 5 shrinkage shrinkage NN cord-010119-t1x9gknd 451 6 . . . cord-010119-t1x9gknd 452 1 At at IN cord-010119-t1x9gknd 452 2 the the DT cord-010119-t1x9gknd 452 3 end end NN cord-010119-t1x9gknd 452 4 of of IN cord-010119-t1x9gknd 452 5 the the DT cord-010119-t1x9gknd 452 6 treatments treatment NNS cord-010119-t1x9gknd 452 7 for for IN cord-010119-t1x9gknd 452 8 48h 48h NNS cord-010119-t1x9gknd 452 9 , , , cord-010119-t1x9gknd 452 10 cells cell NNS cord-010119-t1x9gknd 452 11 treated treat VBN cord-010119-t1x9gknd 452 12 with with IN cord-010119-t1x9gknd 452 13 d35 d35 NNP cord-010119-t1x9gknd 452 14 K K NNP cord-010119-t1x9gknd 452 15 and and CC cord-010119-t1x9gknd 452 16 d35 d35 NNP cord-010119-t1x9gknd 452 17 SSRBCs SSRBCs NNPS cord-010119-t1x9gknd 452 18 both both DT cord-010119-t1x9gknd 452 19 show show VBP cord-010119-t1x9gknd 452 20 obvious obvious JJ cord-010119-t1x9gknd 452 21 shrinkage shrinkage NN cord-010119-t1x9gknd 452 22 , , , cord-010119-t1x9gknd 452 23 the the DT cord-010119-t1x9gknd 452 24 shrinkage shrinkage NN cord-010119-t1x9gknd 452 25 in in IN cord-010119-t1x9gknd 452 26 d35 d35 NNP cord-010119-t1x9gknd 452 27 SSRBCs SSRBCs NNP cord-010119-t1x9gknd 452 28 group group NN cord-010119-t1x9gknd 452 29 was be VBD cord-010119-t1x9gknd 452 30 more more RBR cord-010119-t1x9gknd 452 31 serious serious JJ cord-010119-t1x9gknd 452 32 . . . cord-010119-t1x9gknd 453 1 The the DT cord-010119-t1x9gknd 453 2 immunofluorescence immunofluorescence NN cord-010119-t1x9gknd 453 3 results result NNS cord-010119-t1x9gknd 453 4 show show VBP cord-010119-t1x9gknd 453 5 the the DT cord-010119-t1x9gknd 453 6 integrity integrity NN cord-010119-t1x9gknd 453 7 of of IN cord-010119-t1x9gknd 453 8 filament filament NN cord-010119-t1x9gknd 453 9 and and CC cord-010119-t1x9gknd 453 10 sarcomere sarcomere NN cord-010119-t1x9gknd 453 11 was be VBD cord-010119-t1x9gknd 453 12 complete complete JJ cord-010119-t1x9gknd 453 13 and and CC cord-010119-t1x9gknd 453 14 no no DT cord-010119-t1x9gknd 453 15 nuclear nuclear JJ cord-010119-t1x9gknd 453 16 pyknosis pyknosis NN cord-010119-t1x9gknd 453 17 was be VBD cord-010119-t1x9gknd 453 18 detected detect VBN cord-010119-t1x9gknd 453 19 . . . cord-010119-t1x9gknd 454 1 5 5 LS cord-010119-t1x9gknd 455 1 Gene Gene NNP cord-010119-t1x9gknd 455 2 Expression Expression NNP cord-010119-t1x9gknd 455 3 Array Array NNP cord-010119-t1x9gknd 455 4 results result NNS cord-010119-t1x9gknd 455 5 show show VBP cord-010119-t1x9gknd 455 6 a a DT cord-010119-t1x9gknd 455 7 total total NN cord-010119-t1x9gknd 455 8 of of IN cord-010119-t1x9gknd 455 9 140 140 CD cord-010119-t1x9gknd 455 10 genes gene NNS cord-010119-t1x9gknd 455 11 were be VBD cord-010119-t1x9gknd 455 12 differentially differentially RB cord-010119-t1x9gknd 455 13 expressed express VBN cord-010119-t1x9gknd 455 14 in in IN cord-010119-t1x9gknd 455 15 d35 d35 NNP cord-010119-t1x9gknd 455 16 SSRBCs SSRBCs NNP cord-010119-t1x9gknd 455 17 group group NN cord-010119-t1x9gknd 455 18 compared compare VBN cord-010119-t1x9gknd 455 19 with with IN cord-010119-t1x9gknd 455 20 naive naive JJ cord-010119-t1x9gknd 455 21 group group NN cord-010119-t1x9gknd 455 22 . . . cord-010119-t1x9gknd 456 1 There there EX cord-010119-t1x9gknd 456 2 was be VBD cord-010119-t1x9gknd 456 3 no no DT cord-010119-t1x9gknd 456 4 consistent consistent JJ cord-010119-t1x9gknd 456 5 separation separation NN cord-010119-t1x9gknd 456 6 within within IN cord-010119-t1x9gknd 456 7 the the DT cord-010119-t1x9gknd 456 8 d35 d35 NNP cord-010119-t1x9gknd 456 9 K K NNP cord-010119-t1x9gknd 456 10 and and CC cord-010119-t1x9gknd 456 11 naive naive JJ cord-010119-t1x9gknd 456 12 group group NN cord-010119-t1x9gknd 456 13 . . . cord-010119-t1x9gknd 457 1 Fifteen fifteen CD cord-010119-t1x9gknd 457 2 differently differently RB cord-010119-t1x9gknd 457 3 expressed express VBN cord-010119-t1x9gknd 457 4 genes gene NNS cord-010119-t1x9gknd 457 5 were be VBD cord-010119-t1x9gknd 457 6 selected select VBN cord-010119-t1x9gknd 457 7 with with IN cord-010119-t1x9gknd 457 8 bioinformatics bioinformatics NN cord-010119-t1x9gknd 457 9 method method NN cord-010119-t1x9gknd 457 10 which which WDT cord-010119-t1x9gknd 457 11 were be VBD cord-010119-t1x9gknd 457 12 likely likely JJ cord-010119-t1x9gknd 457 13 to to TO cord-010119-t1x9gknd 457 14 play play VB cord-010119-t1x9gknd 457 15 an an DT cord-010119-t1x9gknd 457 16 important important JJ cord-010119-t1x9gknd 457 17 role role NN cord-010119-t1x9gknd 457 18 in in IN cord-010119-t1x9gknd 457 19 the the DT cord-010119-t1x9gknd 457 20 cytotoxic cytotoxic JJ cord-010119-t1x9gknd 457 21 effect effect NN cord-010119-t1x9gknd 457 22 . . . cord-010119-t1x9gknd 458 1 Under under IN cord-010119-t1x9gknd 458 2 the the DT cord-010119-t1x9gknd 458 3 condition condition NN cord-010119-t1x9gknd 458 4 of of IN cord-010119-t1x9gknd 458 5 simulating simulate VBG cord-010119-t1x9gknd 458 6 the the DT cord-010119-t1x9gknd 458 7 large large JJ cord-010119-t1x9gknd 458 8 volume volume NN cord-010119-t1x9gknd 458 9 blood blood NN cord-010119-t1x9gknd 458 10 transfusion transfusion NN cord-010119-t1x9gknd 458 11 , , , cord-010119-t1x9gknd 458 12 SSRBCs ssrbc NNS cord-010119-t1x9gknd 458 13 of of IN cord-010119-t1x9gknd 458 14 long long JJ cord-010119-t1x9gknd 458 15 term term NN cord-010119-t1x9gknd 458 16 - - HYPH cord-010119-t1x9gknd 458 17 stored store VBN cord-010119-t1x9gknd 458 18 RBCs rbc NNS cord-010119-t1x9gknd 458 19 have have VBP cord-010119-t1x9gknd 458 20 toxic toxic JJ cord-010119-t1x9gknd 458 21 effect effect NN cord-010119-t1x9gknd 458 22 on on IN cord-010119-t1x9gknd 458 23 myocardial myocardial JJ cord-010119-t1x9gknd 458 24 cells cell NNS cord-010119-t1x9gknd 458 25 . . . cord-010119-t1x9gknd 459 1 2 2 LS cord-010119-t1x9gknd 460 1 In in IN cord-010119-t1x9gknd 460 2 addition addition NN cord-010119-t1x9gknd 460 3 to to IN cord-010119-t1x9gknd 460 4 high high JJ cord-010119-t1x9gknd 460 5 potassium potassium NN cord-010119-t1x9gknd 460 6 that that WDT cord-010119-t1x9gknd 460 7 induced induce VBD cord-010119-t1x9gknd 460 8 cardiotoxicity cardiotoxicity NN cord-010119-t1x9gknd 460 9 , , , cord-010119-t1x9gknd 460 10 there there EX cord-010119-t1x9gknd 460 11 must must MD cord-010119-t1x9gknd 460 12 be be VB cord-010119-t1x9gknd 460 13 other other JJ cord-010119-t1x9gknd 460 14 elements element NNS cord-010119-t1x9gknd 460 15 are be VBP cord-010119-t1x9gknd 460 16 involved involve VBN cord-010119-t1x9gknd 460 17 in in IN cord-010119-t1x9gknd 460 18 the the DT cord-010119-t1x9gknd 460 19 toxic toxic JJ cord-010119-t1x9gknd 460 20 effects effect NNS cord-010119-t1x9gknd 460 21 . . . cord-010119-t1x9gknd 461 1 3 3 LS cord-010119-t1x9gknd 462 1 Further further JJ cord-010119-t1x9gknd 462 2 study study NN cord-010119-t1x9gknd 462 3 should should MD cord-010119-t1x9gknd 462 4 be be VB cord-010119-t1x9gknd 462 5 applied apply VBN cord-010119-t1x9gknd 462 6 to to TO cord-010119-t1x9gknd 462 7 signal signal VB cord-010119-t1x9gknd 462 8 pathways pathway NNS cord-010119-t1x9gknd 462 9 on on IN cord-010119-t1x9gknd 462 10 SSRBCs ssrbc NNS cord-010119-t1x9gknd 462 11 induced induce VBD cord-010119-t1x9gknd 462 12 cytotoxicity cytotoxicity NN cord-010119-t1x9gknd 462 13 . . . cord-010119-t1x9gknd 463 1 4 4 CD cord-010119-t1x9gknd 463 2 Large large JJ cord-010119-t1x9gknd 463 3 volume volume NN cord-010119-t1x9gknd 463 4 transfusion transfusion NN cord-010119-t1x9gknd 463 5 of of IN cord-010119-t1x9gknd 463 6 long long JJ cord-010119-t1x9gknd 463 7 term term NN cord-010119-t1x9gknd 463 8 - - HYPH cord-010119-t1x9gknd 463 9 stored store VBN cord-010119-t1x9gknd 463 10 RBCs rbc NNS cord-010119-t1x9gknd 463 11 may may MD cord-010119-t1x9gknd 463 12 be be VB cord-010119-t1x9gknd 463 13 a a DT cord-010119-t1x9gknd 463 14 risk risk NN cord-010119-t1x9gknd 463 15 factor factor NN cord-010119-t1x9gknd 463 16 for for IN cord-010119-t1x9gknd 463 17 adverse adverse JJ cord-010119-t1x9gknd 463 18 clinical clinical JJ cord-010119-t1x9gknd 463 19 outcomes outcome NNS cord-010119-t1x9gknd 463 20 , , , cord-010119-t1x9gknd 463 21 and and CC cord-010119-t1x9gknd 463 22 clinical clinical JJ cord-010119-t1x9gknd 463 23 should should MD cord-010119-t1x9gknd 463 24 pay pay VB cord-010119-t1x9gknd 463 25 attention attention NN cord-010119-t1x9gknd 463 26 to to IN cord-010119-t1x9gknd 463 27 it -PRON- PRP cord-010119-t1x9gknd 463 28 . . . cord-010119-t1x9gknd 464 1 Background Background NNP cord-010119-t1x9gknd 464 2 / / SYM cord-010119-t1x9gknd 464 3 Case Case NNP cord-010119-t1x9gknd 464 4 Studies Studies NNPS cord-010119-t1x9gknd 464 5 : : : cord-010119-t1x9gknd 465 1 Processing processing NN cord-010119-t1x9gknd 465 2 thawed thaw VBN cord-010119-t1x9gknd 465 3 , , , cord-010119-t1x9gknd 465 4 deglycerolized deglycerolize VBN cord-010119-t1x9gknd 465 5 red red JJ cord-010119-t1x9gknd 465 6 cell cell NN cord-010119-t1x9gknd 465 7 concentrates concentrate VBZ cord-010119-t1x9gknd 465 8 ( ( -LRB- cord-010119-t1x9gknd 465 9 RCC RCC NNP cord-010119-t1x9gknd 465 10 ) ) -RRB- cord-010119-t1x9gknd 465 11 in in IN cord-010119-t1x9gknd 465 12 a a DT cord-010119-t1x9gknd 465 13 functionally functionally RB cord-010119-t1x9gknd 465 14 closed closed JJ cord-010119-t1x9gknd 465 15 system system NN cord-010119-t1x9gknd 465 16 allows allow VBZ cord-010119-t1x9gknd 465 17 for for IN cord-010119-t1x9gknd 465 18 a a DT cord-010119-t1x9gknd 465 19 prolonged prolong VBN cord-010119-t1x9gknd 465 20 storage storage NN cord-010119-t1x9gknd 465 21 after after IN cord-010119-t1x9gknd 465 22 thawing thaw VBG cord-010119-t1x9gknd 465 23 . . . cord-010119-t1x9gknd 466 1 Thawed thawed JJ cord-010119-t1x9gknd 466 2 cells cell NNS cord-010119-t1x9gknd 466 3 are be VBP cord-010119-t1x9gknd 466 4 better well RBR cord-010119-t1x9gknd 466 5 maintained maintain VBN cord-010119-t1x9gknd 466 6 in in IN cord-010119-t1x9gknd 466 7 AS-3 AS-3 NNP cord-010119-t1x9gknd 466 8 as as IN cord-010119-t1x9gknd 466 9 compared compare VBN cord-010119-t1x9gknd 466 10 to to IN cord-010119-t1x9gknd 466 11 SAGM SAGM NNP cord-010119-t1x9gknd 466 12 . . . cord-010119-t1x9gknd 467 1 The the DT cord-010119-t1x9gknd 467 2 presence presence NN cord-010119-t1x9gknd 467 3 of of IN cord-010119-t1x9gknd 467 4 citrate citrate NN cord-010119-t1x9gknd 467 5 in in IN cord-010119-t1x9gknd 467 6 AS-3 AS-3 NNP cord-010119-t1x9gknd 467 7 seems seem VBZ cord-010119-t1x9gknd 467 8 to to TO cord-010119-t1x9gknd 467 9 be be VB cord-010119-t1x9gknd 467 10 necessary necessary JJ cord-010119-t1x9gknd 467 11 to to TO cord-010119-t1x9gknd 467 12 prevent prevent VB cord-010119-t1x9gknd 467 13 hemolysis hemolysis NN cord-010119-t1x9gknd 467 14 of of IN cord-010119-t1x9gknd 467 15 thawed thaw VBN cord-010119-t1x9gknd 467 16 cells cell NNS cord-010119-t1x9gknd 467 17 . . . cord-010119-t1x9gknd 468 1 During during IN cord-010119-t1x9gknd 468 2 storage storage NN cord-010119-t1x9gknd 468 3 in in IN cord-010119-t1x9gknd 468 4 AS-3 AS-3 NNP cord-010119-t1x9gknd 468 5 , , , cord-010119-t1x9gknd 468 6 ATP ATP NNP cord-010119-t1x9gknd 468 7 and and CC cord-010119-t1x9gknd 468 8 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 468 9 levels level NNS cord-010119-t1x9gknd 468 10 rapidly rapidly RB cord-010119-t1x9gknd 468 11 decline decline VBP cord-010119-t1x9gknd 468 12 . . . cord-010119-t1x9gknd 469 1 Recently recently RB cord-010119-t1x9gknd 469 2 developed develop VBD cord-010119-t1x9gknd 469 3 additive additive NN cord-010119-t1x9gknd 469 4 solutions solution NNS cord-010119-t1x9gknd 469 5 like like IN cord-010119-t1x9gknd 470 1 PAG3 PAG3 NNP cord-010119-t1x9gknd 470 2 M M NNP cord-010119-t1x9gknd 470 3 and and CC cord-010119-t1x9gknd 470 4 AS-7 AS-7 NNP cord-010119-t1x9gknd 470 5 have have VBP cord-010119-t1x9gknd 470 6 shown show VBN cord-010119-t1x9gknd 470 7 to to TO cord-010119-t1x9gknd 470 8 better well RBR cord-010119-t1x9gknd 470 9 maintain maintain VB cord-010119-t1x9gknd 470 10 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 470 11 and and CC cord-010119-t1x9gknd 470 12 ATP ATP NNP cord-010119-t1x9gknd 470 13 levels level NNS cord-010119-t1x9gknd 470 14 during during IN cord-010119-t1x9gknd 470 15 storage storage NN cord-010119-t1x9gknd 470 16 of of IN cord-010119-t1x9gknd 470 17 normal normal JJ cord-010119-t1x9gknd 470 18 , , , cord-010119-t1x9gknd 470 19 unfrozen unfrozen JJ cord-010119-t1x9gknd 470 20 , , , cord-010119-t1x9gknd 470 21 RCC RCC NNP cord-010119-t1x9gknd 470 22 . . . cord-010119-t1x9gknd 471 1 However however RB cord-010119-t1x9gknd 471 2 , , , cord-010119-t1x9gknd 471 3 most most RBS cord-010119-t1x9gknd 471 4 probably probably RB cord-010119-t1x9gknd 471 5 due due JJ cord-010119-t1x9gknd 471 6 to to IN cord-010119-t1x9gknd 471 7 the the DT cord-010119-t1x9gknd 471 8 absence absence NN cord-010119-t1x9gknd 471 9 of of IN cord-010119-t1x9gknd 471 10 citrate citrate NN cord-010119-t1x9gknd 471 11 , , , cord-010119-t1x9gknd 471 12 these these DT cord-010119-t1x9gknd 471 13 solutions solution NNS cord-010119-t1x9gknd 471 14 are be VBP cord-010119-t1x9gknd 471 15 not not RB cord-010119-t1x9gknd 471 16 suitable suitable JJ cord-010119-t1x9gknd 471 17 for for IN cord-010119-t1x9gknd 471 18 storage storage NN cord-010119-t1x9gknd 471 19 of of IN cord-010119-t1x9gknd 471 20 thawed thaw VBN cord-010119-t1x9gknd 471 21 cells cell NNS cord-010119-t1x9gknd 471 22 . . . cord-010119-t1x9gknd 472 1 We -PRON- PRP cord-010119-t1x9gknd 472 2 therefore therefore RB cord-010119-t1x9gknd 472 3 designed design VBD cord-010119-t1x9gknd 472 4 PAG3C PAG3C NNS cord-010119-t1x9gknd 472 5 in in IN cord-010119-t1x9gknd 472 6 which which WDT cord-010119-t1x9gknd 472 7 the the DT cord-010119-t1x9gknd 472 8 mannitol mannitol NN cord-010119-t1x9gknd 472 9 of of IN cord-010119-t1x9gknd 472 10 PAG3 PAG3 NNP cord-010119-t1x9gknd 472 11 M M NNP cord-010119-t1x9gknd 472 12 was be VBD cord-010119-t1x9gknd 472 13 replaced replace VBN cord-010119-t1x9gknd 472 14 by by IN cord-010119-t1x9gknd 472 15 citrate citrate NNP cord-010119-t1x9gknd 472 16 . . . cord-010119-t1x9gknd 473 1 The the DT cord-010119-t1x9gknd 473 2 aim aim NN cord-010119-t1x9gknd 473 3 of of IN cord-010119-t1x9gknd 473 4 this this DT cord-010119-t1x9gknd 473 5 study study NN cord-010119-t1x9gknd 473 6 was be VBD cord-010119-t1x9gknd 473 7 to to TO cord-010119-t1x9gknd 473 8 investigate investigate VB cord-010119-t1x9gknd 473 9 the the DT cord-010119-t1x9gknd 473 10 in in IN cord-010119-t1x9gknd 473 11 vitroquality vitroquality NN cord-010119-t1x9gknd 473 12 of of IN cord-010119-t1x9gknd 473 13 thawed thaw VBN cord-010119-t1x9gknd 473 14 , , , cord-010119-t1x9gknd 473 15 deglycerolized deglycerolize VBD cord-010119-t1x9gknd 473 16 RBC RBC NNP cord-010119-t1x9gknd 473 17 during during IN cord-010119-t1x9gknd 473 18 storage storage NN cord-010119-t1x9gknd 473 19 at at IN cord-010119-t1x9gknd 473 20 2 2 CD cord-010119-t1x9gknd 473 21 - - HYPH cord-010119-t1x9gknd 473 22 68C 68C NNS cord-010119-t1x9gknd 473 23 in in IN cord-010119-t1x9gknd 473 24 PAG3C. pag3c. NN cord-010119-t1x9gknd 474 1 Study Study NNP cord-010119-t1x9gknd 474 2 Design Design NNP cord-010119-t1x9gknd 474 3 / / SYM cord-010119-t1x9gknd 474 4 Method method NN cord-010119-t1x9gknd 474 5 : : : cord-010119-t1x9gknd 474 6 Leukoreduced Leukoreduced NNP cord-010119-t1x9gknd 474 7 RCC RCC NNP cord-010119-t1x9gknd 474 8 ( ( -LRB- cord-010119-t1x9gknd 474 9 n56 n56 NNP cord-010119-t1x9gknd 474 10 ) ) -RRB- cord-010119-t1x9gknd 474 11 in in IN cord-010119-t1x9gknd 474 12 PAG3C PAG3C NNS cord-010119-t1x9gknd 474 13 ( ( -LRB- cord-010119-t1x9gknd 474 14 phosphate phosphate NN cord-010119-t1x9gknd 474 15 , , , cord-010119-t1x9gknd 474 16 adenine adenine NN cord-010119-t1x9gknd 474 17 , , , cord-010119-t1x9gknd 474 18 glucose glucose NN cord-010119-t1x9gknd 474 19 , , , cord-010119-t1x9gknd 474 20 guanosine guanosine NN cord-010119-t1x9gknd 474 21 , , , cord-010119-t1x9gknd 474 22 gluconate gluconate NN cord-010119-t1x9gknd 474 23 , , , cord-010119-t1x9gknd 474 24 citrate citrate NNP cord-010119-t1x9gknd 474 25 ) ) -RRB- cord-010119-t1x9gknd 474 26 were be VBD cord-010119-t1x9gknd 474 27 stored store VBN cord-010119-t1x9gknd 474 28 at at IN cord-010119-t1x9gknd 474 29 2- 2- CD cord-010119-t1x9gknd 475 1 68C. 68c. LS cord-010119-t1x9gknd 476 1 On on IN cord-010119-t1x9gknd 476 2 day day NN cord-010119-t1x9gknd 476 3 8 8 CD cord-010119-t1x9gknd 476 4 , , , cord-010119-t1x9gknd 476 5 RCCs rcc NNS cord-010119-t1x9gknd 476 6 were be VBD cord-010119-t1x9gknd 476 7 glycerolized glycerolize VBN cord-010119-t1x9gknd 476 8 using use VBG cord-010119-t1x9gknd 476 9 ACP215 ACP215 NNP cord-010119-t1x9gknd 476 10 ( ( -LRB- cord-010119-t1x9gknd 476 11 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 476 12 V V NNP cord-010119-t1x9gknd 476 13 R R NNP cord-010119-t1x9gknd 476 14 , , , cord-010119-t1x9gknd 476 15 Braintree Braintree NNP cord-010119-t1x9gknd 476 16 , , , cord-010119-t1x9gknd 476 17 MA MA NNP cord-010119-t1x9gknd 476 18 ) ) -RRB- cord-010119-t1x9gknd 476 19 to to IN cord-010119-t1x9gknd 476 20 a a DT cord-010119-t1x9gknd 476 21 final final JJ cord-010119-t1x9gknd 476 22 concentration concentration NN cord-010119-t1x9gknd 476 23 of of IN cord-010119-t1x9gknd 476 24 40 40 CD cord-010119-t1x9gknd 476 25 % % NN cord-010119-t1x9gknd 476 26 ( ( -LRB- cord-010119-t1x9gknd 476 27 w w NN cord-010119-t1x9gknd 476 28 / / SYM cord-010119-t1x9gknd 476 29 v v NN cord-010119-t1x9gknd 476 30 ) ) -RRB- cord-010119-t1x9gknd 476 31 , , , cord-010119-t1x9gknd 476 32 frozen frozen JJ cord-010119-t1x9gknd 476 33 and and CC cord-010119-t1x9gknd 476 34 stored store VBN cord-010119-t1x9gknd 476 35 for for IN cord-010119-t1x9gknd 476 36 at at RB cord-010119-t1x9gknd 476 37 least least RBS cord-010119-t1x9gknd 476 38 two two CD cord-010119-t1x9gknd 476 39 weeks week NNS cord-010119-t1x9gknd 476 40 at at IN cord-010119-t1x9gknd 476 41 -808C. -808C. . cord-010119-t1x9gknd 477 1 After after IN cord-010119-t1x9gknd 477 2 thawing thaw VBG cord-010119-t1x9gknd 477 3 and and CC cord-010119-t1x9gknd 477 4 deglycerolization deglycerolization NN cord-010119-t1x9gknd 477 5 using use VBG cord-010119-t1x9gknd 477 6 ACP215 ACP215 NNP cord-010119-t1x9gknd 477 7 , , , cord-010119-t1x9gknd 477 8 RCC RCC NNP cord-010119-t1x9gknd 477 9 were be VBD cord-010119-t1x9gknd 477 10 resuspended resuspend VBN cord-010119-t1x9gknd 477 11 in in IN cord-010119-t1x9gknd 477 12 PAG3C. pag3c. NN cord-010119-t1x9gknd 478 1 During during IN cord-010119-t1x9gknd 478 2 storage storage NN cord-010119-t1x9gknd 478 3 at at IN cord-010119-t1x9gknd 478 4 2 2 CD cord-010119-t1x9gknd 478 5 - - HYPH cord-010119-t1x9gknd 478 6 68C 68C NNS cord-010119-t1x9gknd 478 7 , , , cord-010119-t1x9gknd 478 8 stability stability NN cord-010119-t1x9gknd 478 9 ( ( -LRB- cord-010119-t1x9gknd 478 10 hemolysis hemolysis NN cord-010119-t1x9gknd 478 11 ) ) -RRB- cord-010119-t1x9gknd 478 12 , , , cord-010119-t1x9gknd 478 13 ATP ATP NNP cord-010119-t1x9gknd 478 14 and and CC cord-010119-t1x9gknd 478 15 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 478 16 levels level NNS cord-010119-t1x9gknd 478 17 were be VBD cord-010119-t1x9gknd 478 18 determined determine VBN cord-010119-t1x9gknd 478 19 . . . cord-010119-t1x9gknd 479 1 Results result NNS cord-010119-t1x9gknd 479 2 were be VBD cord-010119-t1x9gknd 479 3 compared compare VBN cord-010119-t1x9gknd 479 4 with with IN cord-010119-t1x9gknd 479 5 thawed thaw VBN cord-010119-t1x9gknd 479 6 RCC RCC NNP cord-010119-t1x9gknd 479 7 ( ( -LRB- cord-010119-t1x9gknd 479 8 prefreeze prefreeze NNP cord-010119-t1x9gknd 479 9 storage storage NN cord-010119-t1x9gknd 479 10 in in IN cord-010119-t1x9gknd 479 11 SAGM SAGM NNP cord-010119-t1x9gknd 479 12 , , , cord-010119-t1x9gknd 479 13 n58 n58 CD cord-010119-t1x9gknd 479 14 ) ) -RRB- cord-010119-t1x9gknd 479 15 resuspended resuspend VBD cord-010119-t1x9gknd 479 16 in in IN cord-010119-t1x9gknd 479 17 or or CC cord-010119-t1x9gknd 479 18 SAGM SAGM NNP cord-010119-t1x9gknd 479 19 ( ( -LRB- cord-010119-t1x9gknd 479 20 n54 n54 NN cord-010119-t1x9gknd 479 21 ) ) -RRB- cord-010119-t1x9gknd 479 22 . . . cord-010119-t1x9gknd 480 1 Results/ Results/ . cord-010119-t1x9gknd 481 1 Finding finding NN cord-010119-t1x9gknd 481 2 : : : cord-010119-t1x9gknd 482 1 Pre pre JJ cord-010119-t1x9gknd 482 2 - - JJ cord-010119-t1x9gknd 482 3 freeze freeze JJ cord-010119-t1x9gknd 482 4 storage storage NN cord-010119-t1x9gknd 482 5 in in IN cord-010119-t1x9gknd 482 6 PAG3C PAG3C NNS cord-010119-t1x9gknd 482 7 resulted result VBD cord-010119-t1x9gknd 482 8 in in IN cord-010119-t1x9gknd 482 9 increased increase VBN cord-010119-t1x9gknd 482 10 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 482 11 levels level NNS cord-010119-t1x9gknd 482 12 at at IN cord-010119-t1x9gknd 482 13 day day NN cord-010119-t1x9gknd 482 14 8 8 CD cord-010119-t1x9gknd 482 15 as as IN cord-010119-t1x9gknd 482 16 compared compare VBN cord-010119-t1x9gknd 482 17 to to IN cord-010119-t1x9gknd 482 18 storage storage NN cord-010119-t1x9gknd 482 19 in in IN cord-010119-t1x9gknd 482 20 SAGM SAGM NNP cord-010119-t1x9gknd 482 21 , , , cord-010119-t1x9gknd 482 22 resp resp NNP cord-010119-t1x9gknd 482 23 . . . cord-010119-t1x9gknd 483 1 9.1 9.1 CD cord-010119-t1x9gknd 483 2 6 6 CD cord-010119-t1x9gknd 483 3 7.6 7.6 CD cord-010119-t1x9gknd 483 4 mmol mmol JJ cord-010119-t1x9gknd 483 5 / / SYM cord-010119-t1x9gknd 483 6 g g NNP cord-010119-t1x9gknd 483 7 Hb Hb NNP cord-010119-t1x9gknd 483 8 and and CC cord-010119-t1x9gknd 483 9 1.9 1.9 CD cord-010119-t1x9gknd 483 10 6 6 CD cord-010119-t1x9gknd 483 11 0.7 0.7 CD cord-010119-t1x9gknd 483 12 mmol mmol JJ cord-010119-t1x9gknd 483 13 / / SYM cord-010119-t1x9gknd 483 14 g g NNP cord-010119-t1x9gknd 483 15 Hb Hb NNP cord-010119-t1x9gknd 483 16 . . . cord-010119-t1x9gknd 484 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 484 2 during during IN cord-010119-t1x9gknd 484 3 post post JJ cord-010119-t1x9gknd 484 4 - - JJ cord-010119-t1x9gknd 484 5 thaw thaw JJ cord-010119-t1x9gknd 484 6 storage storage NN cord-010119-t1x9gknd 484 7 in in IN cord-010119-t1x9gknd 484 8 PAG3C PAG3C NNS cord-010119-t1x9gknd 484 9 remained remain VBD cord-010119-t1x9gknd 484 10 below below IN cord-010119-t1x9gknd 484 11 0.8 0.8 CD cord-010119-t1x9gknd 484 12 % % NN cord-010119-t1x9gknd 484 13 for for IN cord-010119-t1x9gknd 484 14 35 35 CD cord-010119-t1x9gknd 484 15 days day NNS cord-010119-t1x9gknd 484 16 and and CC cord-010119-t1x9gknd 484 17 was be VBD cord-010119-t1x9gknd 484 18 comparable comparable JJ cord-010119-t1x9gknd 484 19 with with IN cord-010119-t1x9gknd 484 20 storage storage NN cord-010119-t1x9gknd 484 21 in in IN cord-010119-t1x9gknd 484 22 AS-3 AS-3 NNP cord-010119-t1x9gknd 484 23 . . . cord-010119-t1x9gknd 485 1 In in IN cord-010119-t1x9gknd 485 2 SAGM SAGM NNP cord-010119-t1x9gknd 485 3 , , , cord-010119-t1x9gknd 485 4 hemolysis hemolysis NN cord-010119-t1x9gknd 485 5 remained remain VBD cord-010119-t1x9gknd 485 6 below below IN cord-010119-t1x9gknd 485 7 0.8 0.8 CD cord-010119-t1x9gknd 485 8 % % NN cord-010119-t1x9gknd 485 9 for for IN cord-010119-t1x9gknd 485 10 7 7 CD cord-010119-t1x9gknd 485 11 days day NNS cord-010119-t1x9gknd 485 12 . . . cord-010119-t1x9gknd 486 1 During during IN cord-010119-t1x9gknd 486 2 the the DT cord-010119-t1x9gknd 486 3 first first JJ cord-010119-t1x9gknd 486 4 2 2 CD cord-010119-t1x9gknd 486 5 weeks week NNS cord-010119-t1x9gknd 486 6 of of IN cord-010119-t1x9gknd 486 7 post post JJ cord-010119-t1x9gknd 486 8 - - JJ cord-010119-t1x9gknd 486 9 thaw thaw JJ cord-010119-t1x9gknd 486 10 storage storage NN cord-010119-t1x9gknd 486 11 in in IN cord-010119-t1x9gknd 486 12 PAG3C PAG3C NNS cord-010119-t1x9gknd 486 13 , , , cord-010119-t1x9gknd 486 14 both both CC cord-010119-t1x9gknd 486 15 ATP ATP NNP cord-010119-t1x9gknd 486 16 and and CC cord-010119-t1x9gknd 486 17 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 486 18 levels level NNS cord-010119-t1x9gknd 486 19 increased increase VBN cord-010119-t1x9gknd 486 20 , , , cord-010119-t1x9gknd 486 21 followed follow VBN cord-010119-t1x9gknd 486 22 by by IN cord-010119-t1x9gknd 486 23 a a DT cord-010119-t1x9gknd 486 24 gradual gradual JJ cord-010119-t1x9gknd 486 25 decline decline NN cord-010119-t1x9gknd 486 26 during during IN cord-010119-t1x9gknd 486 27 prolonged prolonged JJ cord-010119-t1x9gknd 486 28 storage storage NN cord-010119-t1x9gknd 486 29 . . . cord-010119-t1x9gknd 487 1 During during IN cord-010119-t1x9gknd 487 2 the the DT cord-010119-t1x9gknd 487 3 whole whole JJ cord-010119-t1x9gknd 487 4 postthaw postthaw JJ cord-010119-t1x9gknd 487 5 storage storage NN cord-010119-t1x9gknd 487 6 period period NN cord-010119-t1x9gknd 487 7 , , , cord-010119-t1x9gknd 487 8 RCCs rcc NNS cord-010119-t1x9gknd 487 9 in in IN cord-010119-t1x9gknd 487 10 PAG3C PAG3C NNS cord-010119-t1x9gknd 487 11 showed show VBD cord-010119-t1x9gknd 487 12 significantly significantly RB cord-010119-t1x9gknd 487 13 higher high JJR cord-010119-t1x9gknd 487 14 ATP ATP NNP cord-010119-t1x9gknd 487 15 and and CC cord-010119-t1x9gknd 487 16 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 487 17 levels level NNS cord-010119-t1x9gknd 487 18 compared compare VBN cord-010119-t1x9gknd 487 19 to to IN cord-010119-t1x9gknd 487 20 AS-3 AS-3 NNP cord-010119-t1x9gknd 487 21 or or CC cord-010119-t1x9gknd 487 22 SAGM SAGM NNP cord-010119-t1x9gknd 487 23 . . . cord-010119-t1x9gknd 488 1 While while IN cord-010119-t1x9gknd 488 2 in in IN cord-010119-t1x9gknd 488 3 SAGM SAGM NNP cord-010119-t1x9gknd 488 4 and and CC cord-010119-t1x9gknd 488 5 AS-3 AS-3 NNP cord-010119-t1x9gknd 488 6 , , , cord-010119-t1x9gknd 488 7 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 488 8 levels level NNS cord-010119-t1x9gknd 488 9 were be VBD cord-010119-t1x9gknd 488 10 undetectable undetectable JJ cord-010119-t1x9gknd 488 11 after after IN cord-010119-t1x9gknd 488 12 7 7 CD cord-010119-t1x9gknd 488 13 days day NNS cord-010119-t1x9gknd 488 14 post post NN cord-010119-t1x9gknd 488 15 - - JJ cord-010119-t1x9gknd 488 16 thaw thaw JJ cord-010119-t1x9gknd 488 17 storage storage NN cord-010119-t1x9gknd 488 18 , , , cord-010119-t1x9gknd 488 19 in in IN cord-010119-t1x9gknd 488 20 PAG3C PAG3C NNS cord-010119-t1x9gknd 488 21 , , , cord-010119-t1x9gknd 488 22 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 488 23 levels level NNS cord-010119-t1x9gknd 488 24 only only RB cord-010119-t1x9gknd 488 25 decreased decrease VBD cord-010119-t1x9gknd 488 26 to to IN cord-010119-t1x9gknd 488 27 6.1 6.1 CD cord-010119-t1x9gknd 488 28 lmol/ lmol/ CD cord-010119-t1x9gknd 489 1 g g NNP cord-010119-t1x9gknd 489 2 Hb Hb NNP cord-010119-t1x9gknd 489 3 after after IN cord-010119-t1x9gknd 489 4 35 35 CD cord-010119-t1x9gknd 489 5 days day NNS cord-010119-t1x9gknd 489 6 of of IN cord-010119-t1x9gknd 489 7 storage storage NN cord-010119-t1x9gknd 489 8 . . . cord-010119-t1x9gknd 490 1 Conclusion conclusion NN cord-010119-t1x9gknd 490 2 : : : cord-010119-t1x9gknd 491 1 Pre pre JJ cord-010119-t1x9gknd 491 2 - - JJ cord-010119-t1x9gknd 491 3 freeze freeze JJ cord-010119-t1x9gknd 491 4 storage storage NN cord-010119-t1x9gknd 491 5 in in IN cord-010119-t1x9gknd 491 6 PAG3C PAG3C NNS cord-010119-t1x9gknd 491 7 resulted result VBD cord-010119-t1x9gknd 491 8 in in IN cord-010119-t1x9gknd 491 9 increased increase VBN cord-010119-t1x9gknd 491 10 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 491 11 levels level NNS cord-010119-t1x9gknd 491 12 . . . cord-010119-t1x9gknd 492 1 As as IN cord-010119-t1x9gknd 492 2 compared compare VBN cord-010119-t1x9gknd 492 3 to to IN cord-010119-t1x9gknd 492 4 AS-3 AS-3 NNP cord-010119-t1x9gknd 492 5 , , , cord-010119-t1x9gknd 492 6 post post JJ cord-010119-t1x9gknd 492 7 - - JJ cord-010119-t1x9gknd 492 8 thaw thaw JJ cord-010119-t1x9gknd 492 9 storage storage NN cord-010119-t1x9gknd 492 10 in in IN cord-010119-t1x9gknd 492 11 PAG3C PAG3C NNS cord-010119-t1x9gknd 492 12 showed show VBD cord-010119-t1x9gknd 492 13 comparable comparable JJ cord-010119-t1x9gknd 492 14 hemolysis hemolysis NN cord-010119-t1x9gknd 492 15 while while IN cord-010119-t1x9gknd 492 16 ATP ATP NNP cord-010119-t1x9gknd 492 17 and and CC cord-010119-t1x9gknd 492 18 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 492 19 levels level NNS cord-010119-t1x9gknd 492 20 were be VBD cord-010119-t1x9gknd 492 21 much much RB cord-010119-t1x9gknd 492 22 better well RBR cord-010119-t1x9gknd 492 23 maintained maintain VBN cord-010119-t1x9gknd 492 24 . . . cord-010119-t1x9gknd 493 1 Based base VBN cord-010119-t1x9gknd 493 2 on on IN cord-010119-t1x9gknd 493 3 a a DT cord-010119-t1x9gknd 493 4 maximum maximum JJ cord-010119-t1x9gknd 493 5 allowed allow VBN cord-010119-t1x9gknd 493 6 hemolysis hemolysis NN cord-010119-t1x9gknd 493 7 of of IN cord-010119-t1x9gknd 493 8 0.8 0.8 CD cord-010119-t1x9gknd 493 9 % % NN cord-010119-t1x9gknd 493 10 and and CC cord-010119-t1x9gknd 493 11 an an DT cord-010119-t1x9gknd 493 12 ATP ATP NNP cord-010119-t1x9gknd 493 13 content content NN cord-010119-t1x9gknd 493 14 of of IN cord-010119-t1x9gknd 493 15 > > XX cord-010119-t1x9gknd 493 16 2.7mmol 2.7mmol CD cord-010119-t1x9gknd 493 17 / / SYM cord-010119-t1x9gknd 493 18 g g NNP cord-010119-t1x9gknd 493 19 Hb Hb NNP cord-010119-t1x9gknd 493 20 , , , cord-010119-t1x9gknd 493 21 thawed thaw VBD cord-010119-t1x9gknd 493 22 RCC RCC NNP cord-010119-t1x9gknd 493 23 can can MD cord-010119-t1x9gknd 493 24 be be VB cord-010119-t1x9gknd 493 25 stored store VBN cord-010119-t1x9gknd 493 26 at at IN cord-010119-t1x9gknd 493 27 2 2 CD cord-010119-t1x9gknd 493 28 - - HYPH cord-010119-t1x9gknd 493 29 68C 68C NNS cord-010119-t1x9gknd 493 30 for for IN cord-010119-t1x9gknd 493 31 35 35 CD cord-010119-t1x9gknd 493 32 days day NNS cord-010119-t1x9gknd 493 33 in in IN cord-010119-t1x9gknd 493 34 PAG3C. PAG3C. NNP cord-010119-t1x9gknd 493 35 Background Background NNP cord-010119-t1x9gknd 493 36 / / SYM cord-010119-t1x9gknd 493 37 Case Case NNP cord-010119-t1x9gknd 493 38 Studies Studies NNPS cord-010119-t1x9gknd 493 39 : : : cord-010119-t1x9gknd 493 40 Platelets platelet NNS cord-010119-t1x9gknd 493 41 ( ( -LRB- cord-010119-t1x9gknd 493 42 PLTs plt NNS cord-010119-t1x9gknd 493 43 ) ) -RRB- cord-010119-t1x9gknd 493 44 are be VBP cord-010119-t1x9gknd 493 45 vital vital JJ cord-010119-t1x9gknd 493 46 for for IN cord-010119-t1x9gknd 493 47 effective effective JJ cord-010119-t1x9gknd 493 48 treatment treatment NN cord-010119-t1x9gknd 493 49 of of IN cord-010119-t1x9gknd 493 50 hemorrhage hemorrhage NN cord-010119-t1x9gknd 493 51 . . . cord-010119-t1x9gknd 494 1 Cold cold JJ cord-010119-t1x9gknd 494 2 ( ( -LRB- cord-010119-t1x9gknd 494 3 48C 48c CD cord-010119-t1x9gknd 494 4 , , , cord-010119-t1x9gknd 494 5 4C 4c CD cord-010119-t1x9gknd 494 6 ) ) -RRB- cord-010119-t1x9gknd 494 7 storage storage NN cord-010119-t1x9gknd 494 8 of of IN cord-010119-t1x9gknd 494 9 PLTs plt NNS cord-010119-t1x9gknd 494 10 in in IN cord-010119-t1x9gknd 494 11 platelet platelet NN cord-010119-t1x9gknd 494 12 additive additive NN cord-010119-t1x9gknd 494 13 solution solution NN cord-010119-t1x9gknd 494 14 ( ( -LRB- cord-010119-t1x9gknd 494 15 PAS pas NN cord-010119-t1x9gknd 494 16 ) ) -RRB- cord-010119-t1x9gknd 494 17 is be VBZ cord-010119-t1x9gknd 494 18 a a DT cord-010119-t1x9gknd 494 19 promising promising JJ cord-010119-t1x9gknd 494 20 alternative alternative NN cord-010119-t1x9gknd 494 21 to to IN cord-010119-t1x9gknd 494 22 conventional conventional JJ cord-010119-t1x9gknd 494 23 storage storage NN cord-010119-t1x9gknd 494 24 at at IN cord-010119-t1x9gknd 494 25 room room NN cord-010119-t1x9gknd 494 26 temperature temperature NN cord-010119-t1x9gknd 494 27 ( ( -LRB- cord-010119-t1x9gknd 494 28 RT RT NNP cord-010119-t1x9gknd 494 29 ) ) -RRB- cord-010119-t1x9gknd 494 30 due due IN cord-010119-t1x9gknd 494 31 to to IN cord-010119-t1x9gknd 494 32 a a DT cord-010119-t1x9gknd 494 33 lower low JJR cord-010119-t1x9gknd 494 34 risk risk NN cord-010119-t1x9gknd 494 35 of of IN cord-010119-t1x9gknd 494 36 bacterial bacterial JJ cord-010119-t1x9gknd 494 37 concerns concern NNS cord-010119-t1x9gknd 494 38 , , , cord-010119-t1x9gknd 494 39 preservation preservation NN cord-010119-t1x9gknd 494 40 of of IN cord-010119-t1x9gknd 494 41 PLT PLT NNP cord-010119-t1x9gknd 494 42 function function NN cord-010119-t1x9gknd 494 43 , , , cord-010119-t1x9gknd 494 44 and and CC cord-010119-t1x9gknd 494 45 mitigation mitigation NN cord-010119-t1x9gknd 494 46 of of IN cord-010119-t1x9gknd 494 47 PLT PLT NNP cord-010119-t1x9gknd 494 48 activation activation NN cord-010119-t1x9gknd 494 49 . . . cord-010119-t1x9gknd 495 1 Currently currently RB cord-010119-t1x9gknd 495 2 only only RB cord-010119-t1x9gknd 495 3 2 2 CD cord-010119-t1x9gknd 495 4 apheresis apheresis NN cord-010119-t1x9gknd 495 5 ( ( -LRB- cord-010119-t1x9gknd 495 6 AP AP NNP cord-010119-t1x9gknd 495 7 ) ) -RRB- cord-010119-t1x9gknd 495 8 and and CC cord-010119-t1x9gknd 495 9 PAS pas NN cord-010119-t1x9gknd 495 10 systems system NNS cord-010119-t1x9gknd 495 11 are be VBP cord-010119-t1x9gknd 495 12 FDA FDA NNP cord-010119-t1x9gknd 495 13 - - HYPH cord-010119-t1x9gknd 495 14 approved approve VBN cord-010119-t1x9gknd 495 15 for for IN cord-010119-t1x9gknd 495 16 use use NN cord-010119-t1x9gknd 495 17 in in IN cord-010119-t1x9gknd 495 18 the the DT cord-010119-t1x9gknd 495 19 US US NNP cord-010119-t1x9gknd 495 20 : : : cord-010119-t1x9gknd 496 1 Trima Trima NNP cord-010119-t1x9gknd 496 2 and and CC cord-010119-t1x9gknd 496 3 Isoplate Isoplate NNP cord-010119-t1x9gknd 496 4 - - HYPH cord-010119-t1x9gknd 496 5 PAS pas NN cord-010119-t1x9gknd 496 6 ( ( -LRB- cord-010119-t1x9gknd 496 7 ISO iso NN cord-010119-t1x9gknd 496 8 ; ; : cord-010119-t1x9gknd 496 9 Terumo Terumo NNP cord-010119-t1x9gknd 496 10 ) ) -RRB- cord-010119-t1x9gknd 496 11 and and CC cord-010119-t1x9gknd 496 12 Amicus Amicus NNP cord-010119-t1x9gknd 496 13 and and CC cord-010119-t1x9gknd 496 14 Intersol Intersol NNP cord-010119-t1x9gknd 496 15 ( ( -LRB- cord-010119-t1x9gknd 496 16 INT INT NNP cord-010119-t1x9gknd 496 17 ; ; : cord-010119-t1x9gknd 496 18 Fenwal Fenwal NNP cord-010119-t1x9gknd 496 19 ) ) -RRB- cord-010119-t1x9gknd 496 20 . . . cord-010119-t1x9gknd 497 1 The the DT cord-010119-t1x9gknd 497 2 goal goal NN cord-010119-t1x9gknd 497 3 of of IN cord-010119-t1x9gknd 497 4 this this DT cord-010119-t1x9gknd 497 5 study study NN cord-010119-t1x9gknd 497 6 was be VBD cord-010119-t1x9gknd 497 7 to to TO cord-010119-t1x9gknd 497 8 assess assess VB cord-010119-t1x9gknd 497 9 the the DT cord-010119-t1x9gknd 497 10 adhesive adhesive JJ cord-010119-t1x9gknd 497 11 function function NN cord-010119-t1x9gknd 497 12 of of IN cord-010119-t1x9gknd 497 13 long long JJ cord-010119-t1x9gknd 497 14 - - HYPH cord-010119-t1x9gknd 497 15 term term NN cord-010119-t1x9gknd 497 16 cold cold NN cord-010119-t1x9gknd 497 17 - - HYPH cord-010119-t1x9gknd 497 18 stored store VBN cord-010119-t1x9gknd 497 19 PLTs plt NNS cord-010119-t1x9gknd 497 20 collected collect VBN cord-010119-t1x9gknd 497 21 by by IN cord-010119-t1x9gknd 497 22 FDA FDA NNP cord-010119-t1x9gknd 497 23 - - HYPH cord-010119-t1x9gknd 497 24 approved approve VBN cord-010119-t1x9gknd 497 25 AP AP NNP cord-010119-t1x9gknd 497 26 / / SYM cord-010119-t1x9gknd 497 27 PAS pas NN cord-010119-t1x9gknd 497 28 methods method NNS cord-010119-t1x9gknd 497 29 . . . cord-010119-t1x9gknd 498 1 Study Study NNP cord-010119-t1x9gknd 498 2 Design Design NNP cord-010119-t1x9gknd 498 3 / / SYM cord-010119-t1x9gknd 498 4 Method method NN cord-010119-t1x9gknd 498 5 : : : cord-010119-t1x9gknd 499 1 PLTs plt NNS cord-010119-t1x9gknd 499 2 were be VBD cord-010119-t1x9gknd 499 3 collected collect VBN cord-010119-t1x9gknd 499 4 ( ( -LRB- cord-010119-t1x9gknd 499 5 n54 n54 NN cord-010119-t1x9gknd 499 6 - - HYPH cord-010119-t1x9gknd 499 7 5 5 CD cord-010119-t1x9gknd 499 8 ) ) -RRB- cord-010119-t1x9gknd 499 9 in in IN cord-010119-t1x9gknd 499 10 65 65 CD cord-010119-t1x9gknd 499 11 % % NN cord-010119-t1x9gknd 499 12 ISO iso NN cord-010119-t1x9gknd 499 13 using use VBG cord-010119-t1x9gknd 499 14 a a DT cord-010119-t1x9gknd 499 15 Trima Trima NNP cord-010119-t1x9gknd 499 16 or or CC cord-010119-t1x9gknd 499 17 in in IN cord-010119-t1x9gknd 499 18 65 65 CD cord-010119-t1x9gknd 499 19 % % NN cord-010119-t1x9gknd 499 20 INT int NN cord-010119-t1x9gknd 499 21 using use VBG cord-010119-t1x9gknd 499 22 an an DT cord-010119-t1x9gknd 499 23 Amicus Amicus NNP cord-010119-t1x9gknd 499 24 and and CC cord-010119-t1x9gknd 499 25 stored store VBN cord-010119-t1x9gknd 499 26 for for IN cord-010119-t1x9gknd 499 27 15 15 CD cord-010119-t1x9gknd 499 28 days day NNS cord-010119-t1x9gknd 499 29 at at IN cord-010119-t1x9gknd 499 30 RT RT NNP cord-010119-t1x9gknd 499 31 and and CC cord-010119-t1x9gknd 499 32 4C. 4c. CD cord-010119-t1x9gknd 499 33 Samples sample NNS cord-010119-t1x9gknd 499 34 were be VBD cord-010119-t1x9gknd 499 35 tested test VBN cord-010119-t1x9gknd 499 36 on on IN cord-010119-t1x9gknd 499 37 Day day NN cord-010119-t1x9gknd 499 38 1 1 CD cord-010119-t1x9gknd 499 39 ( ( -LRB- cord-010119-t1x9gknd 499 40 baseline baseline NN cord-010119-t1x9gknd 499 41 , , , cord-010119-t1x9gknd 499 42 BL BL NNP cord-010119-t1x9gknd 499 43 ) ) -RRB- cord-010119-t1x9gknd 499 44 , , , cord-010119-t1x9gknd 499 45 5 5 CD cord-010119-t1x9gknd 499 46 , , , cord-010119-t1x9gknd 499 47 10 10 CD cord-010119-t1x9gknd 499 48 , , , cord-010119-t1x9gknd 499 49 and and CC cord-010119-t1x9gknd 499 50 15 15 CD cord-010119-t1x9gknd 499 51 of of IN cord-010119-t1x9gknd 499 52 storage storage NN cord-010119-t1x9gknd 499 53 to to TO cord-010119-t1x9gknd 499 54 assess assess VB cord-010119-t1x9gknd 499 55 PLT PLT NNP cord-010119-t1x9gknd 499 56 adhesion adhesion NN cord-010119-t1x9gknd 499 57 under under IN cord-010119-t1x9gknd 499 58 shear shear NN cord-010119-t1x9gknd 499 59 flow flow NN cord-010119-t1x9gknd 499 60 ( ( -LRB- cord-010119-t1x9gknd 499 61 Bioflux Bioflux NNP cord-010119-t1x9gknd 499 62 ) ) -RRB- cord-010119-t1x9gknd 499 63 . . . cord-010119-t1x9gknd 500 1 ACD ACD NNP cord-010119-t1x9gknd 500 2 vacutainer vacutainer NN cord-010119-t1x9gknd 500 3 tubes tube NNS cord-010119-t1x9gknd 500 4 were be VBD cord-010119-t1x9gknd 500 5 collected collect VBN cord-010119-t1x9gknd 500 6 from from IN cord-010119-t1x9gknd 500 7 donors donor NNS cord-010119-t1x9gknd 500 8 and and CC cord-010119-t1x9gknd 500 9 centrifuged centrifuge VBD cord-010119-t1x9gknd 500 10 to to TO cord-010119-t1x9gknd 500 11 obtain obtain VB cord-010119-t1x9gknd 500 12 red red JJ cord-010119-t1x9gknd 500 13 blood blood NN cord-010119-t1x9gknd 500 14 cells cell NNS cord-010119-t1x9gknd 500 15 ( ( -LRB- cord-010119-t1x9gknd 500 16 RBCs rbc NNS cord-010119-t1x9gknd 500 17 ) ) -RRB- cord-010119-t1x9gknd 500 18 for for IN cord-010119-t1x9gknd 500 19 all all DT cord-010119-t1x9gknd 500 20 Bioflux Bioflux NNP cord-010119-t1x9gknd 500 21 runs run VBZ cord-010119-t1x9gknd 500 22 . . . cord-010119-t1x9gknd 501 1 Simulated simulated JJ cord-010119-t1x9gknd 501 2 whole whole JJ cord-010119-t1x9gknd 501 3 blood blood NN cord-010119-t1x9gknd 501 4 was be VBD cord-010119-t1x9gknd 501 5 created create VBN cord-010119-t1x9gknd 501 6 by by IN cord-010119-t1x9gknd 501 7 combining combine VBG cord-010119-t1x9gknd 501 8 PLTs plt NNS cord-010119-t1x9gknd 501 9 labeled label VBN cord-010119-t1x9gknd 501 10 with with IN cord-010119-t1x9gknd 501 11 calcein calcein NNP cord-010119-t1x9gknd 501 12 - - HYPH cord-010119-t1x9gknd 501 13 AM am NN cord-010119-t1x9gknd 501 14 with with IN cord-010119-t1x9gknd 501 15 RBCs rbc NNS cord-010119-t1x9gknd 501 16 at at IN cord-010119-t1x9gknd 501 17 40 40 CD cord-010119-t1x9gknd 501 18 % % NN cord-010119-t1x9gknd 501 19 Hct Hct NNP cord-010119-t1x9gknd 501 20 . . . cord-010119-t1x9gknd 502 1 Labeled label VBN cord-010119-t1x9gknd 502 2 blood blood NN cord-010119-t1x9gknd 502 3 was be VBD cord-010119-t1x9gknd 502 4 perfused perfuse VBN cord-010119-t1x9gknd 502 5 through through IN cord-010119-t1x9gknd 502 6 microfluidic microfluidic JJ cord-010119-t1x9gknd 502 7 channels channel NNS cord-010119-t1x9gknd 502 8 ( ( -LRB- cord-010119-t1x9gknd 502 9 Fluxion Fluxion NNP cord-010119-t1x9gknd 502 10 ) ) -RRB- cord-010119-t1x9gknd 502 11 coated coat VBD cord-010119-t1x9gknd 502 12 with with IN cord-010119-t1x9gknd 502 13 100 100 CD cord-010119-t1x9gknd 502 14 ug ug NNP cord-010119-t1x9gknd 502 15 / / SYM cord-010119-t1x9gknd 502 16 ml ml NN cord-010119-t1x9gknd 502 17 type-1 type-1 NN cord-010119-t1x9gknd 502 18 collagen collagen NN cord-010119-t1x9gknd 502 19 at at IN cord-010119-t1x9gknd 502 20 720s 720s NNP cord-010119-t1x9gknd 502 21 -1 -1 NN cord-010119-t1x9gknd 502 22 shear shear NN cord-010119-t1x9gknd 502 23 rate rate NN cord-010119-t1x9gknd 502 24 . . . cord-010119-t1x9gknd 503 1 Images image NNS cord-010119-t1x9gknd 503 2 were be VBD cord-010119-t1x9gknd 503 3 acquired acquire VBN cord-010119-t1x9gknd 503 4 every every DT cord-010119-t1x9gknd 503 5 30 30 CD cord-010119-t1x9gknd 503 6 sec sec NNP cord-010119-t1x9gknd 503 7 for for IN cord-010119-t1x9gknd 503 8 10 10 CD cord-010119-t1x9gknd 503 9 min min NN cord-010119-t1x9gknd 503 10 using use VBG cord-010119-t1x9gknd 503 11 a a DT cord-010119-t1x9gknd 503 12 fluorescent fluorescent JJ cord-010119-t1x9gknd 503 13 microscope microscope NN cord-010119-t1x9gknd 503 14 and and CC cord-010119-t1x9gknd 503 15 % % NN cord-010119-t1x9gknd 503 16 surface surface NN cord-010119-t1x9gknd 503 17 coverage coverage NN cord-010119-t1x9gknd 503 18 was be VBD cord-010119-t1x9gknd 503 19 reported report VBN cord-010119-t1x9gknd 503 20 . . . cord-010119-t1x9gknd 504 1 Data datum NNS cord-010119-t1x9gknd 504 2 were be VBD cord-010119-t1x9gknd 504 3 analyzed analyze VBN cord-010119-t1x9gknd 504 4 using use VBG cord-010119-t1x9gknd 504 5 two two CD cord-010119-t1x9gknd 504 6 - - HYPH cord-010119-t1x9gknd 504 7 way way NN cord-010119-t1x9gknd 504 8 ANOVA ANOVA NNP cord-010119-t1x9gknd 504 9 and and CC cord-010119-t1x9gknd 504 10 posthoc posthoc NNP cord-010119-t1x9gknd 504 11 Tukey Tukey NNP cord-010119-t1x9gknd 504 12 test test NN cord-010119-t1x9gknd 504 13 with with IN cord-010119-t1x9gknd 504 14 significance significance NN cord-010119-t1x9gknd 504 15 at at IN cord-010119-t1x9gknd 504 16 P<0.05 P<0.05 NNS cord-010119-t1x9gknd 504 17 . . . cord-010119-t1x9gknd 505 1 Results/ Results/ . cord-010119-t1x9gknd 506 1 Finding finding NN cord-010119-t1x9gknd 506 2 : : : cord-010119-t1x9gknd 507 1 Both both DT cord-010119-t1x9gknd 507 2 RT RT NNP cord-010119-t1x9gknd 507 3 - - HYPH cord-010119-t1x9gknd 507 4 INT INT NNP cord-010119-t1x9gknd 507 5 and and CC cord-010119-t1x9gknd 507 6 RT RT NNP cord-010119-t1x9gknd 507 7 - - HYPH cord-010119-t1x9gknd 507 8 ISO ISO NNP cord-010119-t1x9gknd 507 9 PLTs plt NNS cord-010119-t1x9gknd 507 10 showed show VBD cord-010119-t1x9gknd 507 11 significantly significantly RB cord-010119-t1x9gknd 507 12 decreased decrease VBD cord-010119-t1x9gknd 507 13 adhesion adhesion NN cord-010119-t1x9gknd 507 14 by by IN cord-010119-t1x9gknd 507 15 Day Day NNP cord-010119-t1x9gknd 507 16 5 5 CD cord-010119-t1x9gknd 507 17 of of IN cord-010119-t1x9gknd 507 18 storage storage NN cord-010119-t1x9gknd 507 19 compared compare VBN cord-010119-t1x9gknd 507 20 to to IN cord-010119-t1x9gknd 507 21 BL BL NNP cord-010119-t1x9gknd 507 22 ( ( -LRB- cord-010119-t1x9gknd 507 23 BL bl NN cord-010119-t1x9gknd 507 24 : : : cord-010119-t1x9gknd 507 25 11.6 11.6 CD cord-010119-t1x9gknd 507 26 6 6 CD cord-010119-t1x9gknd 507 27 1.7 1.7 CD cord-010119-t1x9gknd 507 28 % % NN cord-010119-t1x9gknd 507 29 , , , cord-010119-t1x9gknd 507 30 RT RT NNP cord-010119-t1x9gknd 507 31 : : : cord-010119-t1x9gknd 507 32 4.9 4.9 CD cord-010119-t1x9gknd 507 33 6 6 CD cord-010119-t1x9gknd 507 34 1.2 1.2 CD cord-010119-t1x9gknd 507 35 % % NN cord-010119-t1x9gknd 507 36 ; ; , cord-010119-t1x9gknd 507 37 p<0.005 p<0.005 CD cord-010119-t1x9gknd 507 38 ) ) -RRB- cord-010119-t1x9gknd 507 39 . . . cord-010119-t1x9gknd 508 1 4C 4c LS cord-010119-t1x9gknd 508 2 - - HYPH cord-010119-t1x9gknd 508 3 INT int NN cord-010119-t1x9gknd 508 4 samples sample NNS cord-010119-t1x9gknd 508 5 showed show VBD cord-010119-t1x9gknd 508 6 no no DT cord-010119-t1x9gknd 508 7 difference difference NN cord-010119-t1x9gknd 508 8 in in IN cord-010119-t1x9gknd 508 9 adhesion adhesion NN cord-010119-t1x9gknd 508 10 at at IN cord-010119-t1x9gknd 508 11 any any DT cord-010119-t1x9gknd 508 12 timepoint timepoint NN cord-010119-t1x9gknd 508 13 compared compare VBN cord-010119-t1x9gknd 508 14 to to IN cord-010119-t1x9gknd 508 15 BL BL NNP cord-010119-t1x9gknd 508 16 - - HYPH cord-010119-t1x9gknd 508 17 INT int NN cord-010119-t1x9gknd 508 18 but but CC cord-010119-t1x9gknd 508 19 significantly significantly RB cord-010119-t1x9gknd 508 20 enhanced enhance VBN cord-010119-t1x9gknd 508 21 adhesion adhesion NN cord-010119-t1x9gknd 508 22 compared compare VBN cord-010119-t1x9gknd 508 23 to to IN cord-010119-t1x9gknd 508 24 both both DT cord-010119-t1x9gknd 508 25 RT RT NNP cord-010119-t1x9gknd 508 26 - - HYPH cord-010119-t1x9gknd 508 27 INT INT NNP cord-010119-t1x9gknd 508 28 and and CC cord-010119-t1x9gknd 508 29 RT rt NN cord-010119-t1x9gknd 508 30 - - HYPH cord-010119-t1x9gknd 508 31 ISO ISO NNP cord-010119-t1x9gknd 508 32 . . . cord-010119-t1x9gknd 509 1 In in IN cord-010119-t1x9gknd 509 2 contrast contrast NN cord-010119-t1x9gknd 509 3 , , , cord-010119-t1x9gknd 509 4 4C 4c CD cord-010119-t1x9gknd 509 5 - - HYPH cord-010119-t1x9gknd 509 6 ISO ISO NNP cord-010119-t1x9gknd 509 7 PLTs plt NNS cord-010119-t1x9gknd 509 8 showed show VBD cord-010119-t1x9gknd 509 9 significant significant JJ cord-010119-t1x9gknd 509 10 enhancement enhancement NN cord-010119-t1x9gknd 509 11 of of IN cord-010119-t1x9gknd 509 12 surface surface NN cord-010119-t1x9gknd 509 13 coverage coverage NN cord-010119-t1x9gknd 509 14 compared compare VBN cord-010119-t1x9gknd 509 15 to to IN cord-010119-t1x9gknd 509 16 BL BL NNP cord-010119-t1x9gknd 509 17 - - HYPH cord-010119-t1x9gknd 509 18 ISO ISO NNP cord-010119-t1x9gknd 509 19 by by IN cord-010119-t1x9gknd 509 20 Day day NN cord-010119-t1x9gknd 509 21 5 5 CD cord-010119-t1x9gknd 509 22 ( ( -LRB- cord-010119-t1x9gknd 509 23 P50.03 p50.03 CD cord-010119-t1x9gknd 509 24 ) ) -RRB- cord-010119-t1x9gknd 509 25 and and CC cord-010119-t1x9gknd 509 26 compared compare VBN cord-010119-t1x9gknd 509 27 to to IN cord-010119-t1x9gknd 509 28 4C 4c CD cord-010119-t1x9gknd 509 29 - - HYPH cord-010119-t1x9gknd 509 30 INT INT NNP cord-010119-t1x9gknd 509 31 by by IN cord-010119-t1x9gknd 509 32 Day Day NNP cord-010119-t1x9gknd 509 33 10 10 CD cord-010119-t1x9gknd 509 34 ( ( -LRB- cord-010119-t1x9gknd 509 35 P<0.01 p<0.01 CD cord-010119-t1x9gknd 509 36 ) ) -RRB- cord-010119-t1x9gknd 509 37 . . . cord-010119-t1x9gknd 510 1 Conclusion conclusion NN cord-010119-t1x9gknd 510 2 : : : cord-010119-t1x9gknd 511 1 Our -PRON- PRP$ cord-010119-t1x9gknd 511 2 work work NN cord-010119-t1x9gknd 511 3 suggests suggest VBZ cord-010119-t1x9gknd 511 4 that that IN cord-010119-t1x9gknd 511 5 4C 4c CD cord-010119-t1x9gknd 511 6 storage storage NN cord-010119-t1x9gknd 511 7 of of IN cord-010119-t1x9gknd 511 8 PLTs plt NNS cord-010119-t1x9gknd 511 9 collected collect VBN cord-010119-t1x9gknd 511 10 with with IN cord-010119-t1x9gknd 511 11 a a DT cord-010119-t1x9gknd 511 12 Trima Trima NNP cord-010119-t1x9gknd 511 13 AP AP NNP cord-010119-t1x9gknd 511 14 system system NN cord-010119-t1x9gknd 511 15 in in IN cord-010119-t1x9gknd 511 16 ISO iso NN cord-010119-t1x9gknd 511 17 for for IN cord-010119-t1x9gknd 511 18 up up IN cord-010119-t1x9gknd 511 19 to to TO cord-010119-t1x9gknd 511 20 15 15 CD cord-010119-t1x9gknd 511 21 days day NNS cord-010119-t1x9gknd 511 22 offers offer VBZ cord-010119-t1x9gknd 511 23 a a DT cord-010119-t1x9gknd 511 24 significant significant JJ cord-010119-t1x9gknd 511 25 enhancement enhancement NN cord-010119-t1x9gknd 511 26 in in IN cord-010119-t1x9gknd 511 27 adhesive adhesive JJ cord-010119-t1x9gknd 511 28 function function NN cord-010119-t1x9gknd 511 29 compared compare VBN cord-010119-t1x9gknd 511 30 to to IN cord-010119-t1x9gknd 511 31 PLTs plt NNS cord-010119-t1x9gknd 511 32 collected collect VBN cord-010119-t1x9gknd 511 33 with with IN cord-010119-t1x9gknd 511 34 an an DT cord-010119-t1x9gknd 511 35 Amicus Amicus NNP cord-010119-t1x9gknd 511 36 system system NN cord-010119-t1x9gknd 511 37 in in IN cord-010119-t1x9gknd 511 38 INT INT NNP cord-010119-t1x9gknd 511 39 and and CC cord-010119-t1x9gknd 511 40 stored store VBN cord-010119-t1x9gknd 511 41 at at IN cord-010119-t1x9gknd 511 42 4C. 4c. CD cord-010119-t1x9gknd 512 1 These these DT cord-010119-t1x9gknd 512 2 results result NNS cord-010119-t1x9gknd 512 3 are be VBP cord-010119-t1x9gknd 512 4 surprising surprising JJ cord-010119-t1x9gknd 512 5 since since IN cord-010119-t1x9gknd 512 6 both both DT cord-010119-t1x9gknd 512 7 4C 4c CD cord-010119-t1x9gknd 512 8 - - HYPH cord-010119-t1x9gknd 512 9 INT int NN cord-010119-t1x9gknd 512 10 and and CC cord-010119-t1x9gknd 512 11 4C 4c CD cord-010119-t1x9gknd 512 12 - - HYPH cord-010119-t1x9gknd 512 13 ISO iso NN cord-010119-t1x9gknd 512 14 have have VBP cord-010119-t1x9gknd 512 15 been be VBN cord-010119-t1x9gknd 512 16 shown show VBN cord-010119-t1x9gknd 512 17 to to TO cord-010119-t1x9gknd 512 18 express express VB cord-010119-t1x9gknd 512 19 similar similar JJ cord-010119-t1x9gknd 512 20 levels level NNS cord-010119-t1x9gknd 512 21 of of IN cord-010119-t1x9gknd 512 22 CD62P cd62p NN cord-010119-t1x9gknd 512 23 , , , cord-010119-t1x9gknd 512 24 PAC-1 PAC-1 NNPS cord-010119-t1x9gknd 512 25 , , , cord-010119-t1x9gknd 512 26 and and CC cord-010119-t1x9gknd 512 27 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 512 28 and and CC cord-010119-t1x9gknd 512 29 may may MD cord-010119-t1x9gknd 512 30 suggest suggest VB cord-010119-t1x9gknd 512 31 differences difference NNS cord-010119-t1x9gknd 512 32 in in IN cord-010119-t1x9gknd 512 33 PAS PAS NNP cord-010119-t1x9gknd 512 34 PLT PLT NNP cord-010119-t1x9gknd 512 35 intracellular intracellular JJ cord-010119-t1x9gknd 512 36 signaling signaling NN cord-010119-t1x9gknd 512 37 . . . cord-010119-t1x9gknd 513 1 As as IN cord-010119-t1x9gknd 513 2 expected expect VBN cord-010119-t1x9gknd 513 3 , , , cord-010119-t1x9gknd 513 4 storage storage NN cord-010119-t1x9gknd 513 5 at at IN cord-010119-t1x9gknd 513 6 4C 4c CD cord-010119-t1x9gknd 513 7 of of IN cord-010119-t1x9gknd 513 8 PLTs plt NNS cord-010119-t1x9gknd 513 9 collected collect VBN cord-010119-t1x9gknd 513 10 on on IN cord-010119-t1x9gknd 513 11 either either DT cord-010119-t1x9gknd 513 12 platform platform NN cord-010119-t1x9gknd 513 13 demonstrated demonstrate VBD cord-010119-t1x9gknd 513 14 superior superior JJ cord-010119-t1x9gknd 513 15 function function NN cord-010119-t1x9gknd 513 16 to to IN cord-010119-t1x9gknd 513 17 RT RT NNP cord-010119-t1x9gknd 513 18 storage storage NN cord-010119-t1x9gknd 513 19 . . . cord-010119-t1x9gknd 514 1 A a DT cord-010119-t1x9gknd 514 2 PLT PLT NNP cord-010119-t1x9gknd 514 3 product product NN cord-010119-t1x9gknd 514 4 with with IN cord-010119-t1x9gknd 514 5 superior superior JJ cord-010119-t1x9gknd 514 6 hemostatic hemostatic JJ cord-010119-t1x9gknd 514 7 function function NN cord-010119-t1x9gknd 514 8 and and CC cord-010119-t1x9gknd 514 9 a a DT cord-010119-t1x9gknd 514 10 shelf shelf NN cord-010119-t1x9gknd 514 11 - - HYPH cord-010119-t1x9gknd 514 12 life life NN cord-010119-t1x9gknd 514 13 3x 3x CD cord-010119-t1x9gknd 514 14 longer long JJR cord-010119-t1x9gknd 514 15 than than IN cord-010119-t1x9gknd 514 16 the the DT cord-010119-t1x9gknd 514 17 current current JJ cord-010119-t1x9gknd 514 18 standard standard JJ cord-010119-t1x9gknd 514 19 - - HYPH cord-010119-t1x9gknd 514 20 ofcare ofcare NN cord-010119-t1x9gknd 514 21 provides provide VBZ cord-010119-t1x9gknd 514 22 the the DT cord-010119-t1x9gknd 514 23 potential potential NN cord-010119-t1x9gknd 514 24 for for IN cord-010119-t1x9gknd 514 25 shipment shipment NN cord-010119-t1x9gknd 514 26 of of IN cord-010119-t1x9gknd 514 27 products product NNS cord-010119-t1x9gknd 514 28 to to IN cord-010119-t1x9gknd 514 29 underserved underserved JJ cord-010119-t1x9gknd 514 30 areas area NNS cord-010119-t1x9gknd 514 31 and and CC cord-010119-t1x9gknd 514 32 may may MD cord-010119-t1x9gknd 514 33 bolster bolster VB cord-010119-t1x9gknd 514 34 PLT PLT NNP cord-010119-t1x9gknd 514 35 availability availability NN cord-010119-t1x9gknd 514 36 for for IN cord-010119-t1x9gknd 514 37 trauma trauma NN cord-010119-t1x9gknd 514 38 care care NN cord-010119-t1x9gknd 514 39 in in IN cord-010119-t1x9gknd 514 40 the the DT cord-010119-t1x9gknd 514 41 US US NNP cord-010119-t1x9gknd 514 42 . . . cord-010119-t1x9gknd 515 1 TABLE table NN cord-010119-t1x9gknd 515 2 1 1 CD cord-010119-t1x9gknd 515 3 . . . cord-010119-t1x9gknd 516 1 Comparisons comparison NNS cord-010119-t1x9gknd 516 2 of of IN cord-010119-t1x9gknd 516 3 white white JJ cord-010119-t1x9gknd 516 4 blood blood NN cord-010119-t1x9gknd 516 5 cell cell NN cord-010119-t1x9gknd 516 6 counts count NNS cord-010119-t1x9gknd 516 7 and and CC cord-010119-t1x9gknd 516 8 percentages percentage NNS cord-010119-t1x9gknd 516 9 of of IN cord-010119-t1x9gknd 516 10 apoptotic apoptotic JJ cord-010119-t1x9gknd 516 11 cells cell NNS cord-010119-t1x9gknd 516 12 in in IN cord-010119-t1x9gknd 516 13 whole whole JJ cord-010119-t1x9gknd 516 14 blood blood NN cord-010119-t1x9gknd 516 15 components component NNS cord-010119-t1x9gknd 516 16 after after IN cord-010119-t1x9gknd 516 17 2-week 2-week CD cord-010119-t1x9gknd 516 18 storage storage NN cord-010119-t1x9gknd 516 19 between between IN cord-010119-t1x9gknd 516 20 unirradiated unirradiated JJ cord-010119-t1x9gknd 516 21 and and CC cord-010119-t1x9gknd 516 22 irradiated irradiate VBN cord-010119-t1x9gknd 516 23 groups group NNS cord-010119-t1x9gknd 516 24 ( ( -LRB- cord-010119-t1x9gknd 516 25 n n NN cord-010119-t1x9gknd 516 26 5 5 CD cord-010119-t1x9gknd 516 27 29 29 CD cord-010119-t1x9gknd 516 28 ) ) -RRB- cord-010119-t1x9gknd 517 1 TANG TANG NNP cord-010119-t1x9gknd 517 2 , , , cord-010119-t1x9gknd 517 3 is be VBZ cord-010119-t1x9gknd 517 4 an an DT cord-010119-t1x9gknd 517 5 anti anti JJ cord-010119-t1x9gknd 517 6 - - JJ cord-010119-t1x9gknd 517 7 inflammatory inflammatory JJ cord-010119-t1x9gknd 517 8 agents agent NNS cord-010119-t1x9gknd 517 9 and and CC cord-010119-t1x9gknd 517 10 has have VBZ cord-010119-t1x9gknd 517 11 a a DT cord-010119-t1x9gknd 517 12 good good JJ cord-010119-t1x9gknd 517 13 safety safety NN cord-010119-t1x9gknd 517 14 records record NNS cord-010119-t1x9gknd 517 15 in in IN cord-010119-t1x9gknd 517 16 clinic clinic NN cord-010119-t1x9gknd 517 17 . . . cord-010119-t1x9gknd 518 1 It -PRON- PRP cord-010119-t1x9gknd 518 2 could could MD cord-010119-t1x9gknd 518 3 reduce reduce VB cord-010119-t1x9gknd 518 4 the the DT cord-010119-t1x9gknd 518 5 severity severity NN cord-010119-t1x9gknd 518 6 of of IN cord-010119-t1x9gknd 518 7 experimental experimental JJ cord-010119-t1x9gknd 518 8 autoimmune autoimmune JJ cord-010119-t1x9gknd 518 9 encephalomyelitis encephalomyelitis NN cord-010119-t1x9gknd 518 10 ( ( -LRB- cord-010119-t1x9gknd 518 11 EAE EAE NNP cord-010119-t1x9gknd 518 12 ) ) -RRB- cord-010119-t1x9gknd 518 13 , , , cord-010119-t1x9gknd 518 14 asthma asthma NN cord-010119-t1x9gknd 518 15 , , , cord-010119-t1x9gknd 518 16 colitis colitis NN cord-010119-t1x9gknd 518 17 , , , cord-010119-t1x9gknd 518 18 systemic systemic JJ cord-010119-t1x9gknd 518 19 lupus lupus NN cord-010119-t1x9gknd 518 20 erythematosus(SLE erythematosus(SLE NNP cord-010119-t1x9gknd 518 21 ) ) -RRB- cord-010119-t1x9gknd 518 22 and and CC cord-010119-t1x9gknd 518 23 other other JJ cord-010119-t1x9gknd 518 24 immune immune JJ cord-010119-t1x9gknd 518 25 diseases disease NNS cord-010119-t1x9gknd 518 26 . . . cord-010119-t1x9gknd 519 1 However however RB cord-010119-t1x9gknd 519 2 , , , cord-010119-t1x9gknd 519 3 its -PRON- PRP$ cord-010119-t1x9gknd 519 4 potential potential NN cord-010119-t1x9gknd 519 5 in in IN cord-010119-t1x9gknd 519 6 inducing induce VBG cord-010119-t1x9gknd 519 7 transfusion transfusion NN cord-010119-t1x9gknd 519 8 tolerance tolerance NN cord-010119-t1x9gknd 519 9 remains remain VBZ cord-010119-t1x9gknd 519 10 to to TO cord-010119-t1x9gknd 519 11 be be VB cord-010119-t1x9gknd 519 12 explored explore VBN cord-010119-t1x9gknd 519 13 . . . cord-010119-t1x9gknd 520 1 The the DT cord-010119-t1x9gknd 520 2 aims aim NNS cord-010119-t1x9gknd 520 3 of of IN cord-010119-t1x9gknd 520 4 our -PRON- PRP$ cord-010119-t1x9gknd 520 5 study study NN cord-010119-t1x9gknd 520 6 are be VBP cord-010119-t1x9gknd 520 7 to to TO cord-010119-t1x9gknd 520 8 find find VB cord-010119-t1x9gknd 520 9 if if IN cord-010119-t1x9gknd 520 10 baicalin baicalin NNP cord-010119-t1x9gknd 520 11 could could MD cord-010119-t1x9gknd 520 12 inhibit inhibit VB cord-010119-t1x9gknd 520 13 red red JJ cord-010119-t1x9gknd 520 14 blood blood NN cord-010119-t1x9gknd 520 15 cell cell NN cord-010119-t1x9gknd 520 16 ( ( -LRB- cord-010119-t1x9gknd 520 17 RBC RBC NNP cord-010119-t1x9gknd 520 18 ) ) -RRB- cord-010119-t1x9gknd 520 19 immunization immunization NN cord-010119-t1x9gknd 520 20 and and CC cord-010119-t1x9gknd 520 21 to to TO cord-010119-t1x9gknd 520 22 elucidate elucidate VB cord-010119-t1x9gknd 520 23 the the DT cord-010119-t1x9gknd 520 24 possible possible JJ cord-010119-t1x9gknd 520 25 mechanism mechanism NN cord-010119-t1x9gknd 520 26 of of IN cord-010119-t1x9gknd 520 27 YIN YIN NNP cord-010119-t1x9gknd 520 28 - - HYPH cord-010119-t1x9gknd 520 29 CHEN CHEN NNP cord-010119-t1x9gknd 520 30 - - HYPH cord-010119-t1x9gknd 520 31 TANG TANG NNP cord-010119-t1x9gknd 520 32 in in IN cord-010119-t1x9gknd 520 33 preventing prevent VBG cord-010119-t1x9gknd 520 34 HDN HDN NNP cord-010119-t1x9gknd 520 35 . . . cord-010119-t1x9gknd 521 1 Study Study NNP cord-010119-t1x9gknd 521 2 Design Design NNP cord-010119-t1x9gknd 521 3 / / SYM cord-010119-t1x9gknd 521 4 Method method NN cord-010119-t1x9gknd 521 5 : : : cord-010119-t1x9gknd 522 1 We -PRON- PRP cord-010119-t1x9gknd 522 2 used use VBD cord-010119-t1x9gknd 522 3 human human JJ cord-010119-t1x9gknd 522 4 red red JJ cord-010119-t1x9gknd 522 5 blood blood NN cord-010119-t1x9gknd 522 6 cells cell NNS cord-010119-t1x9gknd 522 7 with with IN cord-010119-t1x9gknd 522 8 adjuvant adjuvant JJ cord-010119-t1x9gknd 522 9 Lipopolysaccharide Lipopolysaccharide NNP cord-010119-t1x9gknd 522 10 ( ( -LRB- cord-010119-t1x9gknd 522 11 LPS LPS NNP cord-010119-t1x9gknd 522 12 ) ) -RRB- cord-010119-t1x9gknd 522 13 and and CC cord-010119-t1x9gknd 522 14 transfused transfused JJ cord-010119-t1x9gknd 522 15 mice mouse NNS cord-010119-t1x9gknd 522 16 to to TO cord-010119-t1x9gknd 522 17 induce induce VB cord-010119-t1x9gknd 522 18 antibodies antibody NNS cord-010119-t1x9gknd 522 19 , , , cord-010119-t1x9gknd 522 20 as as IN cord-010119-t1x9gknd 522 21 an an DT cord-010119-t1x9gknd 522 22 experimental experimental JJ cord-010119-t1x9gknd 522 23 system system NN cord-010119-t1x9gknd 522 24 to to TO cord-010119-t1x9gknd 522 25 study study VB cord-010119-t1x9gknd 522 26 the the DT cord-010119-t1x9gknd 522 27 effect effect NN cord-010119-t1x9gknd 522 28 of of IN cord-010119-t1x9gknd 522 29 baicalin baicalin NNP cord-010119-t1x9gknd 522 30 on on IN cord-010119-t1x9gknd 522 31 RBC RBC NNP cord-010119-t1x9gknd 522 32 immunization immunization NN cord-010119-t1x9gknd 522 33 . . . cord-010119-t1x9gknd 523 1 Mice mouse NNS cord-010119-t1x9gknd 523 2 were be VBD cord-010119-t1x9gknd 523 3 divided divide VBN cord-010119-t1x9gknd 523 4 into into IN cord-010119-t1x9gknd 523 5 a a DT cord-010119-t1x9gknd 523 6 normal normal JJ cord-010119-t1x9gknd 523 7 control control NN cord-010119-t1x9gknd 523 8 group group NN cord-010119-t1x9gknd 523 9 , , , cord-010119-t1x9gknd 523 10 a a DT cord-010119-t1x9gknd 523 11 human human JJ cord-010119-t1x9gknd 523 12 RBC RBC NNP cord-010119-t1x9gknd 523 13 transfused transfuse VBD cord-010119-t1x9gknd 523 14 positive positive JJ cord-010119-t1x9gknd 523 15 control control NN cord-010119-t1x9gknd 523 16 group group NN cord-010119-t1x9gknd 523 17 receiving receive VBG cord-010119-t1x9gknd 523 18 human human JJ cord-010119-t1x9gknd 523 19 RBC RBC NNP cord-010119-t1x9gknd 523 20 and and CC cord-010119-t1x9gknd 523 21 LPS LPS NNP cord-010119-t1x9gknd 523 22 intravenously intravenously RB cord-010119-t1x9gknd 523 23 weekly weekly VBP cord-010119-t1x9gknd 523 24 for for IN cord-010119-t1x9gknd 523 25 five five CD cord-010119-t1x9gknd 523 26 weeks week NNS cord-010119-t1x9gknd 523 27 , , . cord-010119-t1x9gknd 524 1 a a DT cord-010119-t1x9gknd 524 2 control control NN cord-010119-t1x9gknd 524 3 group group NN cord-010119-t1x9gknd 524 4 receiveing receive VBG cord-010119-t1x9gknd 524 5 dexamethasone dexamethasone NNP cord-010119-t1x9gknd 524 6 ( ( -LRB- cord-010119-t1x9gknd 524 7 10mg 10mg NNP cord-010119-t1x9gknd 524 8 / / SYM cord-010119-t1x9gknd 524 9 kg kg NN cord-010119-t1x9gknd 524 10 / / SYM cord-010119-t1x9gknd 524 11 day day NN cord-010119-t1x9gknd 524 12 ) ) -RRB- cord-010119-t1x9gknd 525 1 intraperitonealy intraperitonealy NNP cord-010119-t1x9gknd 525 2 daily daily NNP cord-010119-t1x9gknd 525 3 for for IN cord-010119-t1x9gknd 525 4 five five CD cord-010119-t1x9gknd 525 5 weeks week NNS cord-010119-t1x9gknd 526 1 , , , cord-010119-t1x9gknd 526 2 a a DT cord-010119-t1x9gknd 526 3 treatment treatment NN cord-010119-t1x9gknd 526 4 group group NN cord-010119-t1x9gknd 526 5 receiving receive VBG cord-010119-t1x9gknd 526 6 baicalin baicalin NNP cord-010119-t1x9gknd 526 7 ( ( -LRB- cord-010119-t1x9gknd 526 8 250mg 250mg NNP cord-010119-t1x9gknd 526 9 / / SYM cord-010119-t1x9gknd 526 10 kg kg NNP cord-010119-t1x9gknd 526 11 / / SYM cord-010119-t1x9gknd 526 12 day day NN cord-010119-t1x9gknd 526 13 ) ) -RRB- cord-010119-t1x9gknd 526 14 intraperitonealy intraperitonealy NNP cord-010119-t1x9gknd 526 15 daily daily NNP cord-010119-t1x9gknd 526 16 for for IN cord-010119-t1x9gknd 526 17 five five CD cord-010119-t1x9gknd 526 18 weeks week NNS cord-010119-t1x9gknd 526 19 . . . cord-010119-t1x9gknd 527 1 Assessment Assessment NNP cord-010119-t1x9gknd 527 2 of of IN cord-010119-t1x9gknd 527 3 human human JJ cord-010119-t1x9gknd 527 4 RBC RBC NNP cord-010119-t1x9gknd 527 5 immunization immunization NN cord-010119-t1x9gknd 527 6 was be VBD cord-010119-t1x9gknd 527 7 performed perform VBN cord-010119-t1x9gknd 527 8 by by IN cord-010119-t1x9gknd 527 9 measuring measure VBG cord-010119-t1x9gknd 527 10 serum serum NN cord-010119-t1x9gknd 527 11 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 527 12 G G NNP cord-010119-t1x9gknd 527 13 ( ( -LRB- cord-010119-t1x9gknd 527 14 IgG IgG NNP cord-010119-t1x9gknd 527 15 ) ) -RRB- cord-010119-t1x9gknd 527 16 and and CC cord-010119-t1x9gknd 527 17 immunoglobulin immunoglobulin NNP cord-010119-t1x9gknd 527 18 M M NNP cord-010119-t1x9gknd 527 19 ( ( -LRB- cord-010119-t1x9gknd 527 20 IgM IgM NNP cord-010119-t1x9gknd 527 21 ) ) -RRB- cord-010119-t1x9gknd 527 22 against against IN cord-010119-t1x9gknd 527 23 human human JJ cord-010119-t1x9gknd 527 24 RBC RBC NNP cord-010119-t1x9gknd 527 25 weekly weekly NN cord-010119-t1x9gknd 527 26 . . . cord-010119-t1x9gknd 528 1 And and CC cord-010119-t1x9gknd 528 2 the the DT cord-010119-t1x9gknd 528 3 lymphocyte lymphocyte NN cord-010119-t1x9gknd 528 4 changes change NNS cord-010119-t1x9gknd 528 5 in in IN cord-010119-t1x9gknd 528 6 spleen spleen NNS cord-010119-t1x9gknd 528 7 are be VBP cord-010119-t1x9gknd 528 8 also also RB cord-010119-t1x9gknd 528 9 monitored monitor VBN cord-010119-t1x9gknd 528 10 by by IN cord-010119-t1x9gknd 528 11 flow flow NN cord-010119-t1x9gknd 528 12 cytometry cytometry NN cord-010119-t1x9gknd 528 13 . . . cord-010119-t1x9gknd 529 1 Results/ Results/ . cord-010119-t1x9gknd 530 1 Finding find VBG cord-010119-t1x9gknd 531 1 : : : cord-010119-t1x9gknd 531 2 We -PRON- PRP cord-010119-t1x9gknd 531 3 found find VBD cord-010119-t1x9gknd 531 4 that that IN cord-010119-t1x9gknd 531 5 baicalin baicalin NNP cord-010119-t1x9gknd 531 6 treatment treatment NN cord-010119-t1x9gknd 531 7 decreased decrease VBD cord-010119-t1x9gknd 531 8 serum serum NN cord-010119-t1x9gknd 531 9 IgG igg NN cord-010119-t1x9gknd 531 10 but but CC cord-010119-t1x9gknd 531 11 not not RB cord-010119-t1x9gknd 531 12 IgM IgM NNP cord-010119-t1x9gknd 531 13 production production NN cord-010119-t1x9gknd 531 14 significantly significantly RB cord-010119-t1x9gknd 531 15 since since IN cord-010119-t1x9gknd 531 16 the the DT cord-010119-t1x9gknd 531 17 second second JJ cord-010119-t1x9gknd 531 18 week week NN cord-010119-t1x9gknd 531 19 , , , cord-010119-t1x9gknd 531 20 with with IN cord-010119-t1x9gknd 531 21 a a DT cord-010119-t1x9gknd 531 22 concomitant concomitant JJ cord-010119-t1x9gknd 531 23 reduction reduction NN cord-010119-t1x9gknd 531 24 in in IN cord-010119-t1x9gknd 531 25 Th17 Th17 NNP cord-010119-t1x9gknd 531 26 cells cell NNS cord-010119-t1x9gknd 531 27 and and CC cord-010119-t1x9gknd 531 28 increase increase NN cord-010119-t1x9gknd 531 29 in in IN cord-010119-t1x9gknd 531 30 CD4 CD4 NNP cord-010119-t1x9gknd 531 31 regulatory regulatory JJ cord-010119-t1x9gknd 531 32 T T NNP cord-010119-t1x9gknd 531 33 cells cell NNS cord-010119-t1x9gknd 531 34 in in IN cord-010119-t1x9gknd 531 35 both both DT cord-010119-t1x9gknd 531 36 spleen spleen NNS cord-010119-t1x9gknd 531 37 and and CC cord-010119-t1x9gknd 531 38 mesenteric mesenteric JJ cord-010119-t1x9gknd 531 39 lymph lymph NN cord-010119-t1x9gknd 531 40 nodes node NNS cord-010119-t1x9gknd 531 41 . . . cord-010119-t1x9gknd 532 1 And and CC cord-010119-t1x9gknd 532 2 there there EX cord-010119-t1x9gknd 532 3 are be VBP cord-010119-t1x9gknd 532 4 no no DT cord-010119-t1x9gknd 532 5 significant significant JJ cord-010119-t1x9gknd 532 6 differences difference NNS cord-010119-t1x9gknd 532 7 in in IN cord-010119-t1x9gknd 532 8 the the DT cord-010119-t1x9gknd 532 9 percentage percentage NN cord-010119-t1x9gknd 532 10 of of IN cord-010119-t1x9gknd 532 11 Th1,Th2,Tfh th1,th2,tfh JJ cord-010119-t1x9gknd 532 12 and and CC cord-010119-t1x9gknd 532 13 Tfr Tfr NNP cord-010119-t1x9gknd 532 14 CD4 CD4 NNP cord-010119-t1x9gknd 532 15 subpopulation subpopulation NN cord-010119-t1x9gknd 532 16 among among IN cord-010119-t1x9gknd 532 17 all all DT cord-010119-t1x9gknd 532 18 groups group NNS cord-010119-t1x9gknd 532 19 . . . cord-010119-t1x9gknd 533 1 In in IN cord-010119-t1x9gknd 533 2 addition addition NN cord-010119-t1x9gknd 533 3 , , , cord-010119-t1x9gknd 533 4 baicalin baicalin NN cord-010119-t1x9gknd 533 5 treatment treatment NN cord-010119-t1x9gknd 533 6 did do VBD cord-010119-t1x9gknd 533 7 n't not RB cord-010119-t1x9gknd 533 8 decrease decrease VB cord-010119-t1x9gknd 533 9 the the DT cord-010119-t1x9gknd 533 10 size size NN cord-010119-t1x9gknd 533 11 of of IN cord-010119-t1x9gknd 533 12 spleen spleen NN cord-010119-t1x9gknd 533 13 and and CC cord-010119-t1x9gknd 533 14 the the DT cord-010119-t1x9gknd 533 15 percentage percentage NN cord-010119-t1x9gknd 533 16 of of IN cord-010119-t1x9gknd 533 17 CD4 CD4 NNP cord-010119-t1x9gknd 533 18 positive positive JJ cord-010119-t1x9gknd 533 19 cells cell NNS cord-010119-t1x9gknd 533 20 in in IN cord-010119-t1x9gknd 533 21 spleen spleen NNS cord-010119-t1x9gknd 533 22 in in IN cord-010119-t1x9gknd 533 23 baicalin baicalin NNP cord-010119-t1x9gknd 533 24 treatment treatment NN cord-010119-t1x9gknd 533 25 mouse mouse NN cord-010119-t1x9gknd 533 26 but but CC cord-010119-t1x9gknd 533 27 in in IN cord-010119-t1x9gknd 533 28 dexamethasone dexamethasone NN cord-010119-t1x9gknd 533 29 treated treat VBN cord-010119-t1x9gknd 533 30 mouse mouse NN cord-010119-t1x9gknd 533 31 . . . cord-010119-t1x9gknd 534 1 Our -PRON- PRP$ cord-010119-t1x9gknd 534 2 results result NNS cord-010119-t1x9gknd 534 3 indicate indicate VBP cord-010119-t1x9gknd 534 4 that that IN cord-010119-t1x9gknd 534 5 baicalin baicalin NNP cord-010119-t1x9gknd 534 6 could could MD cord-010119-t1x9gknd 534 7 inhibit inhibit VB cord-010119-t1x9gknd 534 8 RBC RBC NNP cord-010119-t1x9gknd 534 9 immunization immunization NN cord-010119-t1x9gknd 534 10 especially especially RB cord-010119-t1x9gknd 534 11 IgG IgG NNP cord-010119-t1x9gknd 534 12 production production NN cord-010119-t1x9gknd 534 13 without without IN cord-010119-t1x9gknd 534 14 the the DT cord-010119-t1x9gknd 534 15 damage damage NN cord-010119-t1x9gknd 534 16 to to IN cord-010119-t1x9gknd 534 17 the the DT cord-010119-t1x9gknd 534 18 function function NN cord-010119-t1x9gknd 534 19 of of IN cord-010119-t1x9gknd 534 20 spleen spleen NNS cord-010119-t1x9gknd 534 21 , , , cord-010119-t1x9gknd 534 22 while while IN cord-010119-t1x9gknd 534 23 dexamethasone dexamethasone NN cord-010119-t1x9gknd 534 24 as as IN cord-010119-t1x9gknd 534 25 a a DT cord-010119-t1x9gknd 534 26 wildly wildly RB cord-010119-t1x9gknd 534 27 used use VBN cord-010119-t1x9gknd 534 28 immune immune NN cord-010119-t1x9gknd 534 29 - - HYPH cord-010119-t1x9gknd 534 30 suppressive suppressive JJ cord-010119-t1x9gknd 534 31 drug drug NN cord-010119-t1x9gknd 534 32 in in IN cord-010119-t1x9gknd 534 33 blood blood NN cord-010119-t1x9gknd 534 34 transfusion transfusion NN cord-010119-t1x9gknd 534 35 could could MD cord-010119-t1x9gknd 534 36 damage damage VB cord-010119-t1x9gknd 534 37 the the DT cord-010119-t1x9gknd 534 38 function function NN cord-010119-t1x9gknd 534 39 of of IN cord-010119-t1x9gknd 534 40 spleen spleen NNS cord-010119-t1x9gknd 534 41 . . . cord-010119-t1x9gknd 535 1 Considering consider VBG cord-010119-t1x9gknd 535 2 its -PRON- PRP$ cord-010119-t1x9gknd 535 3 good good JJ cord-010119-t1x9gknd 535 4 safety safety NN cord-010119-t1x9gknd 535 5 records record NNS cord-010119-t1x9gknd 535 6 in in IN cord-010119-t1x9gknd 535 7 clinic clinic NN cord-010119-t1x9gknd 535 8 , , , cord-010119-t1x9gknd 535 9 it -PRON- PRP cord-010119-t1x9gknd 535 10 may may MD cord-010119-t1x9gknd 535 11 be be VB cord-010119-t1x9gknd 535 12 exploited exploit VBN cord-010119-t1x9gknd 535 13 for for IN cord-010119-t1x9gknd 535 14 suppressing suppress VBG cord-010119-t1x9gknd 535 15 transfusion transfusion NN cord-010119-t1x9gknd 535 16 immunization immunization NN cord-010119-t1x9gknd 535 17 events event NNS cord-010119-t1x9gknd 535 18 . . . cord-010119-t1x9gknd 536 1 In in IN cord-010119-t1x9gknd 536 2 addition addition NN cord-010119-t1x9gknd 536 3 , , , cord-010119-t1x9gknd 536 4 our -PRON- PRP$ cord-010119-t1x9gknd 536 5 results result NNS cord-010119-t1x9gknd 536 6 elucidate elucidate VBP cord-010119-t1x9gknd 536 7 the the DT cord-010119-t1x9gknd 536 8 inhibitory inhibitory JJ cord-010119-t1x9gknd 536 9 effect effect NN cord-010119-t1x9gknd 536 10 in in IN cord-010119-t1x9gknd 536 11 antibody antibody NN cord-010119-t1x9gknd 536 12 production production NN cord-010119-t1x9gknd 536 13 of of IN cord-010119-t1x9gknd 536 14 baicalin baicalin NNP cord-010119-t1x9gknd 536 15 may may MD cord-010119-t1x9gknd 536 16 be be VB cord-010119-t1x9gknd 536 17 a a DT cord-010119-t1x9gknd 536 18 possible possible JJ cord-010119-t1x9gknd 536 19 mechanism mechanism NN cord-010119-t1x9gknd 536 20 for for IN cord-010119-t1x9gknd 536 21 YIN YIN NNP cord-010119-t1x9gknd 536 22 - - HYPH cord-010119-t1x9gknd 536 23 CHEN CHEN NNP cord-010119-t1x9gknd 536 24 - - HYPH cord-010119-t1x9gknd 536 25 TANG TANG NNP cord-010119-t1x9gknd 536 26 as as IN cord-010119-t1x9gknd 536 27 a a DT cord-010119-t1x9gknd 536 28 widely widely RB cord-010119-t1x9gknd 536 29 used use VBN cord-010119-t1x9gknd 536 30 Chinese chinese JJ cord-010119-t1x9gknd 536 31 herbal herbal JJ cord-010119-t1x9gknd 536 32 medicines medicine NNS cord-010119-t1x9gknd 536 33 in in IN cord-010119-t1x9gknd 536 34 preventing prevent VBG cord-010119-t1x9gknd 536 35 HDN HDN NNP cord-010119-t1x9gknd 536 36 . . . cord-010119-t1x9gknd 537 1 Comparison comparison NN cord-010119-t1x9gknd 537 2 of of IN cord-010119-t1x9gknd 537 3 Immucor Immucor NNP cord-010119-t1x9gknd 537 4 's 's POS cord-010119-t1x9gknd 537 5 Pak Pak NNP cord-010119-t1x9gknd 537 6 Plus Plus NNP cord-010119-t1x9gknd 537 7 and and CC cord-010119-t1x9gknd 537 8 Pak Pak NNP cord-010119-t1x9gknd 537 9 Lx Lx NNP cord-010119-t1x9gknd 537 10 Assays Assays NNP cord-010119-t1x9gknd 537 11 for for IN cord-010119-t1x9gknd 537 12 the the DT cord-010119-t1x9gknd 537 13 Detection Detection NNP cord-010119-t1x9gknd 537 14 of of IN cord-010119-t1x9gknd 537 15 Human Human NNP cord-010119-t1x9gknd 537 16 Platelet Platelet NNP cord-010119-t1x9gknd 537 17 Alloantibodies Alloantibodies NNP cord-010119-t1x9gknd 537 18 Randy Randy NNP cord-010119-t1x9gknd 537 19 M M NNP cord-010119-t1x9gknd 537 20 Schuller Schuller NNP cord-010119-t1x9gknd 537 21 * * NFP cord-010119-t1x9gknd 537 22 1 1 CD cord-010119-t1x9gknd 537 23 , , , cord-010119-t1x9gknd 537 24 Sarah Sarah NNP cord-010119-t1x9gknd 537 25 Kloss Kloss NNP cord-010119-t1x9gknd 537 26 1 1 CD cord-010119-t1x9gknd 537 27 , , , cord-010119-t1x9gknd 537 28 Sara Sara NNP cord-010119-t1x9gknd 537 29 Crew Crew NNP cord-010119-t1x9gknd 537 30 1 1 CD cord-010119-t1x9gknd 537 31 and and CC cord-010119-t1x9gknd 537 32 Sandra Sandra NNP cord-010119-t1x9gknd 537 33 J J NNP cord-010119-t1x9gknd 537 34 Nance Nance NNP cord-010119-t1x9gknd 537 35 2 2 CD cord-010119-t1x9gknd 537 36 . . . cord-010119-t1x9gknd 538 1 1 1 LS cord-010119-t1x9gknd 539 1 American American NNP cord-010119-t1x9gknd 539 2 Red Red NNP cord-010119-t1x9gknd 539 3 Cross Cross NNP cord-010119-t1x9gknd 539 4 , , , cord-010119-t1x9gknd 539 5 2 2 CD cord-010119-t1x9gknd 539 6 American American NNP cord-010119-t1x9gknd 539 7 Red Red NNP cord-010119-t1x9gknd 539 8 Cross Cross NNP cord-010119-t1x9gknd 539 9 and and CC cord-010119-t1x9gknd 539 10 American American NNP cord-010119-t1x9gknd 539 11 Rare Rare NNP cord-010119-t1x9gknd 539 12 Donor Donor NNP cord-010119-t1x9gknd 539 13 Program Program NNP cord-010119-t1x9gknd 539 14 Background Background NNP cord-010119-t1x9gknd 539 15 / / SYM cord-010119-t1x9gknd 539 16 Case Case NNP cord-010119-t1x9gknd 539 17 Studies Studies NNPS cord-010119-t1x9gknd 539 18 : : : cord-010119-t1x9gknd 539 19 Alloantibodies Alloantibodies NNP cord-010119-t1x9gknd 539 20 directed direct VBD cord-010119-t1x9gknd 539 21 against against IN cord-010119-t1x9gknd 539 22 human human JJ cord-010119-t1x9gknd 539 23 platelet platelet NN cord-010119-t1x9gknd 539 24 membrane membrane NN cord-010119-t1x9gknd 539 25 glycoproteins glycoprotein NNS cord-010119-t1x9gknd 539 26 ( ( -LRB- cord-010119-t1x9gknd 539 27 GP GP NNP cord-010119-t1x9gknd 539 28 ) ) -RRB- cord-010119-t1x9gknd 539 29 Ia Ia NNP cord-010119-t1x9gknd 539 30 , , , cord-010119-t1x9gknd 539 31 IIa IIa NNP cord-010119-t1x9gknd 539 32 , , , cord-010119-t1x9gknd 539 33 IIb IIb NNP cord-010119-t1x9gknd 539 34 , , , cord-010119-t1x9gknd 539 35 IIIa IIIa NNP cord-010119-t1x9gknd 539 36 , , , cord-010119-t1x9gknd 539 37 Ib Ib NNP cord-010119-t1x9gknd 539 38 , , , cord-010119-t1x9gknd 539 39 IX IX NNP cord-010119-t1x9gknd 539 40 , , , cord-010119-t1x9gknd 539 41 IV IV NNP cord-010119-t1x9gknd 539 42 , , , cord-010119-t1x9gknd 539 43 and and CC cord-010119-t1x9gknd 539 44 CD109 CD109 NNP cord-010119-t1x9gknd 539 45 have have VBP cord-010119-t1x9gknd 539 46 been be VBN cord-010119-t1x9gknd 539 47 implicated implicate VBN cord-010119-t1x9gknd 539 48 in in IN cord-010119-t1x9gknd 539 49 several several JJ cord-010119-t1x9gknd 539 50 clinically clinically RB cord-010119-t1x9gknd 539 51 significant significant JJ cord-010119-t1x9gknd 539 52 disorders disorder NNS cord-010119-t1x9gknd 539 53 such such JJ cord-010119-t1x9gknd 539 54 as as IN cord-010119-t1x9gknd 539 55 fetal fetal JJ cord-010119-t1x9gknd 539 56 and and CC cord-010119-t1x9gknd 539 57 neonatal neonatal JJ cord-010119-t1x9gknd 539 58 alloimmune alloimmune JJ cord-010119-t1x9gknd 539 59 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 539 60 ( ( -LRB- cord-010119-t1x9gknd 539 61 FNAIT FNAIT NNP cord-010119-t1x9gknd 539 62 ) ) -RRB- cord-010119-t1x9gknd 539 63 , , , cord-010119-t1x9gknd 539 64 post post JJ cord-010119-t1x9gknd 539 65 - - JJ cord-010119-t1x9gknd 539 66 transfusion transfusion JJ cord-010119-t1x9gknd 539 67 purpura purpura NN cord-010119-t1x9gknd 539 68 ( ( -LRB- cord-010119-t1x9gknd 539 69 PTP PTP NNP cord-010119-t1x9gknd 539 70 ) ) -RRB- cord-010119-t1x9gknd 539 71 , , , cord-010119-t1x9gknd 539 72 refractoriness refractoriness VBP cord-010119-t1x9gknd 539 73 to to IN cord-010119-t1x9gknd 539 74 platelet platelet NN cord-010119-t1x9gknd 539 75 transfusions transfusion NNS cord-010119-t1x9gknd 539 76 , , , cord-010119-t1x9gknd 539 77 and and CC cord-010119-t1x9gknd 539 78 passive passive JJ cord-010119-t1x9gknd 539 79 transfer transfer NN cord-010119-t1x9gknd 539 80 of of IN cord-010119-t1x9gknd 539 81 antibodies antibody NNS cord-010119-t1x9gknd 539 82 in in IN cord-010119-t1x9gknd 539 83 donor donor NN cord-010119-t1x9gknd 539 84 plasma plasma NN cord-010119-t1x9gknd 539 85 . . . cord-010119-t1x9gknd 540 1 Polymorphic polymorphic JJ cord-010119-t1x9gknd 540 2 epitopes epitope NNS cord-010119-t1x9gknd 540 3 on on IN cord-010119-t1x9gknd 540 4 these these DT cord-010119-t1x9gknd 540 5 GPs gps NNS cord-010119-t1x9gknd 540 6 give give VBP cord-010119-t1x9gknd 540 7 rise rise NN cord-010119-t1x9gknd 540 8 to to IN cord-010119-t1x9gknd 540 9 28 28 CD cord-010119-t1x9gknd 540 10 unique unique JJ cord-010119-t1x9gknd 540 11 human human JJ cord-010119-t1x9gknd 540 12 platelet platelet NN cord-010119-t1x9gknd 540 13 antigens antigen NNS cord-010119-t1x9gknd 540 14 ( ( -LRB- cord-010119-t1x9gknd 540 15 HPA HPA NNP cord-010119-t1x9gknd 540 16 ) ) -RRB- cord-010119-t1x9gknd 540 17 . . . cord-010119-t1x9gknd 541 1 Identification identification NN cord-010119-t1x9gknd 541 2 of of IN cord-010119-t1x9gknd 541 3 the the DT cord-010119-t1x9gknd 541 4 specific specific JJ cord-010119-t1x9gknd 541 5 platelet platelet NN cord-010119-t1x9gknd 541 6 alloantibody alloantibody NN cord-010119-t1x9gknd 541 7 is be VBZ cord-010119-t1x9gknd 541 8 crucial crucial JJ cord-010119-t1x9gknd 541 9 in in IN cord-010119-t1x9gknd 541 10 diagnosing diagnose VBG cord-010119-t1x9gknd 541 11 and and CC cord-010119-t1x9gknd 541 12 treating treat VBG cord-010119-t1x9gknd 541 13 these these DT cord-010119-t1x9gknd 541 14 bleeding bleed VBG cord-010119-t1x9gknd 541 15 disorders disorder NNS cord-010119-t1x9gknd 541 16 . . . cord-010119-t1x9gknd 542 1 Currently currently RB cord-010119-t1x9gknd 542 2 the the DT cord-010119-t1x9gknd 542 3 only only JJ cord-010119-t1x9gknd 542 4 510k 510k CD cord-010119-t1x9gknd 542 5 FDA FDA NNP cord-010119-t1x9gknd 542 6 approved approve VBN cord-010119-t1x9gknd 542 7 test test NN cord-010119-t1x9gknd 542 8 permits permit VBZ cord-010119-t1x9gknd 542 9 the the DT cord-010119-t1x9gknd 542 10 identification identification NN cord-010119-t1x9gknd 542 11 of of IN cord-010119-t1x9gknd 542 12 these these DT cord-010119-t1x9gknd 542 13 HPA HPA NNP cord-010119-t1x9gknd 542 14 antibodies antibody NNS cord-010119-t1x9gknd 542 15 to to IN cord-010119-t1x9gknd 542 16 the the DT cord-010119-t1x9gknd 542 17 glycoprotein glycoprotein NN cord-010119-t1x9gknd 542 18 level level NN cord-010119-t1x9gknd 542 19 . . . cord-010119-t1x9gknd 543 1 Immucor Immucor NNP cord-010119-t1x9gknd 543 2 has have VBZ cord-010119-t1x9gknd 543 3 recently recently RB cord-010119-t1x9gknd 543 4 released release VBN cord-010119-t1x9gknd 543 5 Pak Pak NNP cord-010119-t1x9gknd 543 6 Lx Lx NNP cord-010119-t1x9gknd 543 7 , , , cord-010119-t1x9gknd 543 8 a a DT cord-010119-t1x9gknd 543 9 research research NN cord-010119-t1x9gknd 543 10 use use NN cord-010119-t1x9gknd 543 11 only only RB cord-010119-t1x9gknd 543 12 ( ( -LRB- cord-010119-t1x9gknd 543 13 RUO RUO NNP cord-010119-t1x9gknd 543 14 ) ) -RRB- cord-010119-t1x9gknd 543 15 assay assay NN cord-010119-t1x9gknd 543 16 in in IN cord-010119-t1x9gknd 543 17 the the DT cord-010119-t1x9gknd 543 18 United United NNP cord-010119-t1x9gknd 543 19 States States NNP cord-010119-t1x9gknd 543 20 that that WDT cord-010119-t1x9gknd 543 21 has have VBZ cord-010119-t1x9gknd 543 22 the the DT cord-010119-t1x9gknd 543 23 ability ability NN cord-010119-t1x9gknd 543 24 to to TO cord-010119-t1x9gknd 543 25 identify identify VB cord-010119-t1x9gknd 543 26 HPA HPA NNP cord-010119-t1x9gknd 543 27 antibodies antibody NNS cord-010119-t1x9gknd 543 28 to to IN cord-010119-t1x9gknd 543 29 a a DT cord-010119-t1x9gknd 543 30 single single JJ cord-010119-t1x9gknd 543 31 nucleotide nucleotide JJ cord-010119-t1x9gknd 543 32 polymophism polymophism NN cord-010119-t1x9gknd 543 33 ( ( -LRB- cord-010119-t1x9gknd 543 34 SNP SNP NNP cord-010119-t1x9gknd 543 35 ) ) -RRB- cord-010119-t1x9gknd 543 36 . . . cord-010119-t1x9gknd 544 1 We -PRON- PRP cord-010119-t1x9gknd 544 2 compared compare VBD cord-010119-t1x9gknd 544 3 the the DT cord-010119-t1x9gknd 544 4 performance performance NN cord-010119-t1x9gknd 544 5 of of IN cord-010119-t1x9gknd 544 6 Pak Pak NNP cord-010119-t1x9gknd 544 7 Lx Lx NNP cord-010119-t1x9gknd 544 8 to to IN cord-010119-t1x9gknd 544 9 the the DT cord-010119-t1x9gknd 544 10 FDA FDA NNP cord-010119-t1x9gknd 544 11 approved approve VBD cord-010119-t1x9gknd 544 12 Immucor Immucor NNP cord-010119-t1x9gknd 544 13 PakPlus PakPlus NNP cord-010119-t1x9gknd 544 14 . . . cord-010119-t1x9gknd 545 1 Study Study NNP cord-010119-t1x9gknd 545 2 Design Design NNP cord-010119-t1x9gknd 545 3 / / SYM cord-010119-t1x9gknd 545 4 Method method NN cord-010119-t1x9gknd 545 5 : : : cord-010119-t1x9gknd 546 1 We -PRON- PRP cord-010119-t1x9gknd 546 2 compared compare VBD cord-010119-t1x9gknd 546 3 PakPlus PakPlus NNP cord-010119-t1x9gknd 546 4 and and CC cord-010119-t1x9gknd 546 5 Pak Pak NNP cord-010119-t1x9gknd 546 6 Lx Lx NNP cord-010119-t1x9gknd 546 7 results result VBZ cord-010119-t1x9gknd 546 8 from from IN cord-010119-t1x9gknd 546 9 40 40 CD cord-010119-t1x9gknd 546 10 plasma plasma NN cord-010119-t1x9gknd 546 11 and and CC cord-010119-t1x9gknd 546 12 serum serum NN cord-010119-t1x9gknd 546 13 clinical clinical JJ cord-010119-t1x9gknd 546 14 specimens specimen NNS cord-010119-t1x9gknd 546 15 . . . cord-010119-t1x9gknd 547 1 Group group NN cord-010119-t1x9gknd 547 2 1 1 CD cord-010119-t1x9gknd 547 3 contained contain VBD cord-010119-t1x9gknd 547 4 a a DT cord-010119-t1x9gknd 547 5 single single JJ cord-010119-t1x9gknd 547 6 HPA HPA NNP cord-010119-t1x9gknd 547 7 alloantibody alloantibody NN cord-010119-t1x9gknd 547 8 specificity specificity NN cord-010119-t1x9gknd 547 9 with with IN cord-010119-t1x9gknd 547 10 or or CC cord-010119-t1x9gknd 547 11 without without IN cord-010119-t1x9gknd 547 12 HLA HLA NNP cord-010119-t1x9gknd 547 13 antibodies antibody NNS cord-010119-t1x9gknd 547 14 ( ( -LRB- cord-010119-t1x9gknd 547 15 n526 n526 NNP cord-010119-t1x9gknd 547 16 ) ) -RRB- cord-010119-t1x9gknd 547 17 . . . cord-010119-t1x9gknd 548 1 Group group NN cord-010119-t1x9gknd 548 2 2 2 CD cord-010119-t1x9gknd 548 3 included include VBD cord-010119-t1x9gknd 548 4 5 5 CD cord-010119-t1x9gknd 548 5 specimens specimen NNS cord-010119-t1x9gknd 548 6 with with IN cord-010119-t1x9gknd 548 7 HLA HLA NNP cord-010119-t1x9gknd 548 8 antibodies antibody NNS cord-010119-t1x9gknd 548 9 alone alone RB cord-010119-t1x9gknd 548 10 and and CC cord-010119-t1x9gknd 548 11 Group Group NNP cord-010119-t1x9gknd 548 12 3 3 CD cord-010119-t1x9gknd 548 13 consisted consist VBD cord-010119-t1x9gknd 548 14 of of IN cord-010119-t1x9gknd 548 15 9 9 CD cord-010119-t1x9gknd 548 16 patient patient NN cord-010119-t1x9gknd 548 17 samples sample NNS cord-010119-t1x9gknd 548 18 that that WDT cord-010119-t1x9gknd 548 19 were be VBD cord-010119-t1x9gknd 548 20 negative negative JJ cord-010119-t1x9gknd 548 21 for for IN cord-010119-t1x9gknd 548 22 both both DT cord-010119-t1x9gknd 548 23 HPA HPA NNP cord-010119-t1x9gknd 548 24 and and CC cord-010119-t1x9gknd 548 25 HLA HLA NNP cord-010119-t1x9gknd 548 26 antibodies antibody NNS cord-010119-t1x9gknd 548 27 . . . cord-010119-t1x9gknd 549 1 Pak Pak NNP cord-010119-t1x9gknd 549 2 Lx Lx NNP cord-010119-t1x9gknd 549 3 utilizes utilize VBZ cord-010119-t1x9gknd 549 4 a a DT cord-010119-t1x9gknd 549 5 Luminex Luminex NNP cord-010119-t1x9gknd 549 6 bead bead NN cord-010119-t1x9gknd 549 7 based base VBN cord-010119-t1x9gknd 549 8 assay assay NN cord-010119-t1x9gknd 549 9 which which WDT cord-010119-t1x9gknd 549 10 allows allow VBZ cord-010119-t1x9gknd 549 11 the the DT cord-010119-t1x9gknd 549 12 user user NN cord-010119-t1x9gknd 549 13 to to TO cord-010119-t1x9gknd 549 14 report report VB cord-010119-t1x9gknd 549 15 antibodies antibody NNS cord-010119-t1x9gknd 549 16 to to IN cord-010119-t1x9gknd 549 17 the the DT cord-010119-t1x9gknd 549 18 platelet platelet NN cord-010119-t1x9gknd 549 19 specific specific JJ cord-010119-t1x9gknd 549 20 antigen antigen NN cord-010119-t1x9gknd 549 21 ( ( -LRB- cord-010119-t1x9gknd 549 22 HPA-1 HPA-1 NNP cord-010119-t1x9gknd 549 23 , , , cord-010119-t1x9gknd 549 24 HPA-2 HPA-2 NNP cord-010119-t1x9gknd 549 25 , , , cord-010119-t1x9gknd 549 26 HPA-3 HPA-3 NNP cord-010119-t1x9gknd 549 27 , , , cord-010119-t1x9gknd 549 28 HPA-4 HPA-4 NNP cord-010119-t1x9gknd 549 29 , , , cord-010119-t1x9gknd 549 30 HPA-5 HPA-5 NNP cord-010119-t1x9gknd 549 31 , , , cord-010119-t1x9gknd 549 32 GPIV GPIV NNP cord-010119-t1x9gknd 549 33 ) ) -RRB- cord-010119-t1x9gknd 549 34 and and CC cord-010119-t1x9gknd 550 1 HLA HLA NNP cord-010119-t1x9gknd 550 2 Class Class NNP cord-010119-t1x9gknd 550 3 I. I. NNP cord-010119-t1x9gknd 550 4 PakPlus PakPlus NNP cord-010119-t1x9gknd 550 5 uses use VBZ cord-010119-t1x9gknd 550 6 an an DT cord-010119-t1x9gknd 550 7 ELISA ELISA NNP cord-010119-t1x9gknd 550 8 method method NN cord-010119-t1x9gknd 550 9 and and CC cord-010119-t1x9gknd 550 10 results result NNS cord-010119-t1x9gknd 550 11 can can MD cord-010119-t1x9gknd 550 12 only only RB cord-010119-t1x9gknd 550 13 be be VB cord-010119-t1x9gknd 550 14 reported report VBN cord-010119-t1x9gknd 550 15 to to IN cord-010119-t1x9gknd 550 16 the the DT cord-010119-t1x9gknd 550 17 glycoprotein glycoprotein NN cord-010119-t1x9gknd 550 18 location location NN cord-010119-t1x9gknd 550 19 ( ( -LRB- cord-010119-t1x9gknd 550 20 GPIIb GPIIb NNP cord-010119-t1x9gknd 550 21 / / SYM cord-010119-t1x9gknd 550 22 IIIa IIIa NNS cord-010119-t1x9gknd 550 23 , , , cord-010119-t1x9gknd 550 24 GPIa/ GPIa/ NNP cord-010119-t1x9gknd 550 25 IIa IIa NNP cord-010119-t1x9gknd 550 26 , , , cord-010119-t1x9gknd 550 27 GPIb GPIb NNP cord-010119-t1x9gknd 550 28 / / SYM cord-010119-t1x9gknd 550 29 IX IX NNP cord-010119-t1x9gknd 550 30 , , , cord-010119-t1x9gknd 550 31 GPIV GPIV NNP cord-010119-t1x9gknd 550 32 ) ) -RRB- cord-010119-t1x9gknd 550 33 along along IN cord-010119-t1x9gknd 550 34 with with IN cord-010119-t1x9gknd 550 35 HLA HLA NNP cord-010119-t1x9gknd 550 36 Class Class NNP cord-010119-t1x9gknd 550 37 I. i. NN cord-010119-t1x9gknd 551 1 However however RB cord-010119-t1x9gknd 551 2 , , , cord-010119-t1x9gknd 551 3 based base VBN cord-010119-t1x9gknd 551 4 upon upon IN cord-010119-t1x9gknd 551 5 the the DT cord-010119-t1x9gknd 551 6 pattern pattern NN cord-010119-t1x9gknd 551 7 of of IN cord-010119-t1x9gknd 551 8 reactivity reactivity NN cord-010119-t1x9gknd 551 9 observed observe VBN cord-010119-t1x9gknd 551 10 in in IN cord-010119-t1x9gknd 551 11 the the DT cord-010119-t1x9gknd 551 12 PakPlus PakPlus NNP cord-010119-t1x9gknd 551 13 and and CC cord-010119-t1x9gknd 551 14 Pak Pak NNP cord-010119-t1x9gknd 551 15 Lx Lx NNP cord-010119-t1x9gknd 551 16 assays assay NNS cord-010119-t1x9gknd 551 17 it -PRON- PRP cord-010119-t1x9gknd 551 18 is be VBZ cord-010119-t1x9gknd 551 19 possible possible JJ cord-010119-t1x9gknd 551 20 to to TO cord-010119-t1x9gknd 551 21 determine determine VB cord-010119-t1x9gknd 551 22 the the DT cord-010119-t1x9gknd 551 23 most most RBS cord-010119-t1x9gknd 551 24 probable probable JJ cord-010119-t1x9gknd 551 25 HPA HPA NNP cord-010119-t1x9gknd 551 26 antibody antibody NN cord-010119-t1x9gknd 551 27 specificity specificity NN cord-010119-t1x9gknd 551 28 to to IN cord-010119-t1x9gknd 551 29 the the DT cord-010119-t1x9gknd 551 30 HPA HPA NNP cord-010119-t1x9gknd 551 31 SNP SNP NNP cord-010119-t1x9gknd 551 32 . . . cord-010119-t1x9gknd 552 1 Results/ Results/ . cord-010119-t1x9gknd 553 1 Finding finding NN cord-010119-t1x9gknd 553 2 : : : cord-010119-t1x9gknd 554 1 Conclusion conclusion NN cord-010119-t1x9gknd 554 2 : : : cord-010119-t1x9gknd 554 3 When when WRB cord-010119-t1x9gknd 554 4 analyzing analyze VBG cord-010119-t1x9gknd 554 5 HPA HPA NNP cord-010119-t1x9gknd 554 6 antibody antibody NN cord-010119-t1x9gknd 554 7 specificity specificity NN cord-010119-t1x9gknd 554 8 , , , cord-010119-t1x9gknd 554 9 there there EX cord-010119-t1x9gknd 554 10 is be VBZ cord-010119-t1x9gknd 554 11 100 100 CD cord-010119-t1x9gknd 554 12 % % NN cord-010119-t1x9gknd 554 13 concordance concordance NN cord-010119-t1x9gknd 554 14 observed observe VBD cord-010119-t1x9gknd 554 15 for for IN cord-010119-t1x9gknd 554 16 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 554 17 , , , cord-010119-t1x9gknd 554 18 HPA-1b HPA-1b NNP cord-010119-t1x9gknd 554 19 and and CC cord-010119-t1x9gknd 554 20 HPA-5b HPA-5b NNP cord-010119-t1x9gknd 554 21 antibodies antibody NNS cord-010119-t1x9gknd 554 22 . . . cord-010119-t1x9gknd 555 1 The the DT cord-010119-t1x9gknd 555 2 Pak Pak NNP cord-010119-t1x9gknd 555 3 - - HYPH cord-010119-t1x9gknd 555 4 Plus Plus NNP cord-010119-t1x9gknd 555 5 assay assay NN cord-010119-t1x9gknd 555 6 had have VBD cord-010119-t1x9gknd 555 7 difficulty difficulty NN cord-010119-t1x9gknd 555 8 discriminating discriminate VBG cord-010119-t1x9gknd 555 9 HPA-5b HPA-5b NNP cord-010119-t1x9gknd 555 10 from from IN cord-010119-t1x9gknd 555 11 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 555 12 antibody antibody NN cord-010119-t1x9gknd 555 13 when when WRB cord-010119-t1x9gknd 555 14 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 555 15 antibody antibody NN cord-010119-t1x9gknd 555 16 was be VBD cord-010119-t1x9gknd 555 17 present present JJ cord-010119-t1x9gknd 555 18 ( ( -LRB- cord-010119-t1x9gknd 555 19 3 3 CD cord-010119-t1x9gknd 555 20 false false JJ cord-010119-t1x9gknd 555 21 positive positive JJ cord-010119-t1x9gknd 555 22 samples sample NNS cord-010119-t1x9gknd 555 23 ) ) -RRB- cord-010119-t1x9gknd 555 24 although although IN cord-010119-t1x9gknd 555 25 the the DT cord-010119-t1x9gknd 555 26 Pak Pak NNP cord-010119-t1x9gknd 555 27 - - HYPH cord-010119-t1x9gknd 555 28 Plus plus CC cord-010119-t1x9gknd 555 29 signal signal NN cord-010119-t1x9gknd 555 30 OD OD NNP cord-010119-t1x9gknd 555 31 to to IN cord-010119-t1x9gknd 555 32 cutoff cutoff NN cord-010119-t1x9gknd 555 33 OD OD NNP cord-010119-t1x9gknd 555 34 ratio ratio NN cord-010119-t1x9gknd 555 35 was be VBD cord-010119-t1x9gknd 555 36 significantly significantly RB cord-010119-t1x9gknd 555 37 higher high JJR cord-010119-t1x9gknd 555 38 for for IN cord-010119-t1x9gknd 555 39 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 555 40 when when WRB cord-010119-t1x9gknd 555 41 compared compare VBN cord-010119-t1x9gknd 555 42 to to IN cord-010119-t1x9gknd 555 43 HPA-5b HPA-5b NNP cord-010119-t1x9gknd 555 44 in in IN cord-010119-t1x9gknd 555 45 these these DT cord-010119-t1x9gknd 555 46 samples sample NNS cord-010119-t1x9gknd 555 47 . . . cord-010119-t1x9gknd 556 1 The the DT cord-010119-t1x9gknd 556 2 discordant discordant JJ cord-010119-t1x9gknd 556 3 HLA HLA NNP cord-010119-t1x9gknd 556 4 Class Class NNP cord-010119-t1x9gknd 556 5 I -PRON- PRP cord-010119-t1x9gknd 556 6 antibody antibody NN cord-010119-t1x9gknd 556 7 results result VBZ cord-010119-t1x9gknd 556 8 between between IN cord-010119-t1x9gknd 556 9 the the DT cord-010119-t1x9gknd 556 10 assays assay NNS cord-010119-t1x9gknd 556 11 was be VBD cord-010119-t1x9gknd 556 12 isolated isolate VBN cord-010119-t1x9gknd 556 13 to to IN cord-010119-t1x9gknd 556 14 very very RB cord-010119-t1x9gknd 556 15 weakly weakly RB cord-010119-t1x9gknd 556 16 positive positive JJ cord-010119-t1x9gknd 556 17 antibody antibody NN cord-010119-t1x9gknd 556 18 ( ( -LRB- cord-010119-t1x9gknd 556 19 within within IN cord-010119-t1x9gknd 556 20 10 10 CD cord-010119-t1x9gknd 556 21 % % NN cord-010119-t1x9gknd 556 22 of of IN cord-010119-t1x9gknd 556 23 the the DT cord-010119-t1x9gknd 556 24 cut cut NN cord-010119-t1x9gknd 556 25 - - HYPH cord-010119-t1x9gknd 556 26 off off NN cord-010119-t1x9gknd 556 27 for for IN cord-010119-t1x9gknd 556 28 PakPlus PakPlus NNP cord-010119-t1x9gknd 556 29 and and CC cord-010119-t1x9gknd 556 30 < < NNP cord-010119-t1x9gknd 556 31 2.0 2.0 CD cord-010119-t1x9gknd 556 32 adjusted adjust VBN cord-010119-t1x9gknd 556 33 ratio ratio NN cord-010119-t1x9gknd 556 34 for for IN cord-010119-t1x9gknd 556 35 Pak Pak NNP cord-010119-t1x9gknd 556 36 Lx Lx NNP cord-010119-t1x9gknd 556 37 ) ) -RRB- cord-010119-t1x9gknd 556 38 . . . cord-010119-t1x9gknd 557 1 We -PRON- PRP cord-010119-t1x9gknd 557 2 conclude conclude VBP cord-010119-t1x9gknd 557 3 that that IN cord-010119-t1x9gknd 557 4 Pak Pak NNP cord-010119-t1x9gknd 557 5 Lx Lx NNP cord-010119-t1x9gknd 557 6 is be VBZ cord-010119-t1x9gknd 557 7 an an DT cord-010119-t1x9gknd 557 8 easy easy JJ cord-010119-t1x9gknd 557 9 to to TO cord-010119-t1x9gknd 557 10 use use VB cord-010119-t1x9gknd 557 11 platelet platelet NN cord-010119-t1x9gknd 557 12 alloantibody alloantibody NN cord-010119-t1x9gknd 557 13 screening screening NN cord-010119-t1x9gknd 557 14 method method NN cord-010119-t1x9gknd 557 15 that that WDT cord-010119-t1x9gknd 557 16 has have VBZ cord-010119-t1x9gknd 557 17 the the DT cord-010119-t1x9gknd 557 18 ability ability NN cord-010119-t1x9gknd 557 19 to to TO cord-010119-t1x9gknd 557 20 differentiate differentiate VB cord-010119-t1x9gknd 557 21 HPA HPA NNP cord-010119-t1x9gknd 557 22 antibodies antibody NNS cord-010119-t1x9gknd 557 23 to to IN cord-010119-t1x9gknd 557 24 the the DT cord-010119-t1x9gknd 557 25 allele allele NN cord-010119-t1x9gknd 557 26 level level NN cord-010119-t1x9gknd 557 27 . . . cord-010119-t1x9gknd 558 1 Histo Histo NNP cord-010119-t1x9gknd 558 2 - - HYPH cord-010119-t1x9gknd 558 3 Blood Blood NNP cord-010119-t1x9gknd 558 4 Group Group NNP cord-010119-t1x9gknd 559 1 Antigen Antigen NNP cord-010119-t1x9gknd 559 2 Lewis Lewis NNP cord-010119-t1x9gknd 559 3 Y Y NNP cord-010119-t1x9gknd 559 4 Promotes promote VBZ cord-010119-t1x9gknd 559 5 Cell cell NN cord-010119-t1x9gknd 559 6 Migration migration NN cord-010119-t1x9gknd 560 1 Via via IN cord-010119-t1x9gknd 560 2 Regulation regulation NN cord-010119-t1x9gknd 560 3 of of IN cord-010119-t1x9gknd 560 4 Microtubule Microtubule NNP cord-010119-t1x9gknd 560 5 Acetylation Acetylation NNP cord-010119-t1x9gknd 560 6 Huijun Huijun NNP cord-010119-t1x9gknd 560 7 Zhu Zhu NNP cord-010119-t1x9gknd 560 8 * * NFP cord-010119-t1x9gknd 560 9 and and CC cord-010119-t1x9gknd 560 10 Ping Ping NNP cord-010119-t1x9gknd 560 11 Lu Lu NNP cord-010119-t1x9gknd 560 12 . . . cord-010119-t1x9gknd 561 1 Shanghai Shanghai NNP cord-010119-t1x9gknd 561 2 Blood Blood NNP cord-010119-t1x9gknd 561 3 Center Center NNP cord-010119-t1x9gknd 561 4 Background Background NNP cord-010119-t1x9gknd 561 5 / / SYM cord-010119-t1x9gknd 561 6 Case Case NNP cord-010119-t1x9gknd 561 7 Studies Studies NNPS cord-010119-t1x9gknd 561 8 : : : cord-010119-t1x9gknd 561 9 Blood blood NN cord-010119-t1x9gknd 561 10 group group NN cord-010119-t1x9gknd 561 11 antigens antigen NNS cord-010119-t1x9gknd 561 12 are be VBP cord-010119-t1x9gknd 561 13 critical critical JJ cord-010119-t1x9gknd 561 14 for for IN cord-010119-t1x9gknd 561 15 transfusion transfusion NN cord-010119-t1x9gknd 561 16 practices practice NNS cord-010119-t1x9gknd 561 17 as as IN cord-010119-t1x9gknd 561 18 antibodies antibody NNS cord-010119-t1x9gknd 561 19 raised raise VBD cord-010119-t1x9gknd 561 20 against against IN cord-010119-t1x9gknd 561 21 them -PRON- PRP cord-010119-t1x9gknd 561 22 can can MD cord-010119-t1x9gknd 561 23 cause cause VB cord-010119-t1x9gknd 561 24 severe severe JJ cord-010119-t1x9gknd 561 25 transfusion transfusion NN cord-010119-t1x9gknd 561 26 reaction reaction NN cord-010119-t1x9gknd 561 27 . . . cord-010119-t1x9gknd 562 1 Beside beside IN cord-010119-t1x9gknd 562 2 this this DT cord-010119-t1x9gknd 562 3 , , , cord-010119-t1x9gknd 562 4 blood blood NN cord-010119-t1x9gknd 562 5 group group NN cord-010119-t1x9gknd 562 6 antigens antigen NNS cord-010119-t1x9gknd 562 7 themselves -PRON- PRP cord-010119-t1x9gknd 562 8 are be VBP cord-010119-t1x9gknd 562 9 composed compose VBN cord-010119-t1x9gknd 562 10 of of IN cord-010119-t1x9gknd 562 11 sugar sugar NN cord-010119-t1x9gknd 562 12 chains chain NNS cord-010119-t1x9gknd 562 13 , , , cord-010119-t1x9gknd 562 14 proteins protein NNS cord-010119-t1x9gknd 562 15 , , , cord-010119-t1x9gknd 562 16 lipids lipid NNS cord-010119-t1x9gknd 562 17 , , , cord-010119-t1x9gknd 562 18 etc etc FW cord-010119-t1x9gknd 562 19 , , , cord-010119-t1x9gknd 562 20 which which WDT cord-010119-t1x9gknd 562 21 may may MD cord-010119-t1x9gknd 562 22 be be VB cord-010119-t1x9gknd 562 23 involved involve VBN cord-010119-t1x9gknd 562 24 in in IN cord-010119-t1x9gknd 562 25 various various JJ cord-010119-t1x9gknd 562 26 biological biological JJ cord-010119-t1x9gknd 562 27 processes process NNS cord-010119-t1x9gknd 562 28 . . . cord-010119-t1x9gknd 563 1 Lewis Lewis NNP cord-010119-t1x9gknd 563 2 Y Y NNP cord-010119-t1x9gknd 563 3 is be VBZ cord-010119-t1x9gknd 563 4 a a DT cord-010119-t1x9gknd 563 5 histo histo JJ cord-010119-t1x9gknd 563 6 - - HYPH cord-010119-t1x9gknd 563 7 blood blood NN cord-010119-t1x9gknd 563 8 group group NN cord-010119-t1x9gknd 563 9 antigen antigen NN cord-010119-t1x9gknd 563 10 belonging belong VBG cord-010119-t1x9gknd 563 11 to to IN cord-010119-t1x9gknd 563 12 ABH ABH NNP cord-010119-t1x9gknd 563 13 family family NN cord-010119-t1x9gknd 563 14 . . . cord-010119-t1x9gknd 564 1 LeY LeY NNP cord-010119-t1x9gknd 564 2 consists consist VBZ cord-010119-t1x9gknd 564 3 of of IN cord-010119-t1x9gknd 564 4 carbohydrate carbohydrate NN cord-010119-t1x9gknd 564 5 chains chain NNS cord-010119-t1x9gknd 564 6 which which WDT cord-010119-t1x9gknd 564 7 may may MD cord-010119-t1x9gknd 564 8 play play VB cord-010119-t1x9gknd 564 9 important important JJ cord-010119-t1x9gknd 564 10 roles role NNS cord-010119-t1x9gknd 564 11 in in IN cord-010119-t1x9gknd 564 12 cell cell NN cord-010119-t1x9gknd 564 13 recognition recognition NN cord-010119-t1x9gknd 564 14 , , , cord-010119-t1x9gknd 564 15 adhesion adhesion NN cord-010119-t1x9gknd 564 16 as as RB cord-010119-t1x9gknd 564 17 well well RB cord-010119-t1x9gknd 564 18 as as IN cord-010119-t1x9gknd 564 19 migration migration NN cord-010119-t1x9gknd 564 20 , , , cord-010119-t1x9gknd 564 21 which which WDT cord-010119-t1x9gknd 564 22 are be VBP cord-010119-t1x9gknd 564 23 all all DT cord-010119-t1x9gknd 564 24 critical critical JJ cord-010119-t1x9gknd 564 25 steps step NNS cord-010119-t1x9gknd 564 26 in in IN cord-010119-t1x9gknd 564 27 tumor tumor NN cord-010119-t1x9gknd 564 28 progression progression NN cord-010119-t1x9gknd 564 29 and and CC cord-010119-t1x9gknd 564 30 thus thus RB cord-010119-t1x9gknd 564 31 attracts attract VBZ cord-010119-t1x9gknd 564 32 wide wide JJ cord-010119-t1x9gknd 564 33 researches research NNS cord-010119-t1x9gknd 564 34 focusing focus VBG cord-010119-t1x9gknd 564 35 on on IN cord-010119-t1x9gknd 564 36 its -PRON- PRP$ cord-010119-t1x9gknd 564 37 relevance relevance NN cord-010119-t1x9gknd 564 38 in in IN cord-010119-t1x9gknd 564 39 tumor tumor NN cord-010119-t1x9gknd 564 40 biology biology NN cord-010119-t1x9gknd 564 41 . . . cord-010119-t1x9gknd 565 1 LeY LeY NNP cord-010119-t1x9gknd 565 2 is be VBZ cord-010119-t1x9gknd 565 3 demonstrated demonstrate VBN cord-010119-t1x9gknd 565 4 to to TO cord-010119-t1x9gknd 565 5 affect affect VB cord-010119-t1x9gknd 565 6 cell cell NN cord-010119-t1x9gknd 565 7 mirgration mirgration NN cord-010119-t1x9gknd 565 8 via via IN cord-010119-t1x9gknd 565 9 various various JJ cord-010119-t1x9gknd 565 10 mechanisms mechanism NNS cord-010119-t1x9gknd 565 11 . . . cord-010119-t1x9gknd 566 1 However however RB cord-010119-t1x9gknd 566 2 . . . cord-010119-t1x9gknd 567 1 although although IN cord-010119-t1x9gknd 567 2 changes change NNS cord-010119-t1x9gknd 567 3 in in IN cord-010119-t1x9gknd 567 4 cytoskeleton cytoskeleton NN cord-010119-t1x9gknd 567 5 organization organization NN cord-010119-t1x9gknd 567 6 is be VBZ cord-010119-t1x9gknd 567 7 the the DT cord-010119-t1x9gknd 567 8 basis basis NN cord-010119-t1x9gknd 567 9 for for IN cord-010119-t1x9gknd 567 10 cell cell NN cord-010119-t1x9gknd 567 11 motility motility NN cord-010119-t1x9gknd 567 12 , , , cord-010119-t1x9gknd 567 13 little little JJ cord-010119-t1x9gknd 567 14 is be VBZ cord-010119-t1x9gknd 567 15 known know VBN cord-010119-t1x9gknd 567 16 about about IN cord-010119-t1x9gknd 567 17 the the DT cord-010119-t1x9gknd 567 18 association association NN cord-010119-t1x9gknd 567 19 between between IN cord-010119-t1x9gknd 567 20 cytoskeleton cytoskeleton NN cord-010119-t1x9gknd 567 21 and and CC cord-010119-t1x9gknd 568 1 LeY. LeY. NNP cord-010119-t1x9gknd 568 2 As as IN cord-010119-t1x9gknd 568 3 microtubule microtubule NN cord-010119-t1x9gknd 568 4 and and CC cord-010119-t1x9gknd 568 5 its -PRON- PRP$ cord-010119-t1x9gknd 568 6 construction construction NN cord-010119-t1x9gknd 568 7 unit unit NN cord-010119-t1x9gknd 568 8 tubulin tubulin NN cord-010119-t1x9gknd 568 9 participate participate VBP cord-010119-t1x9gknd 568 10 in in IN cord-010119-t1x9gknd 568 11 various various JJ cord-010119-t1x9gknd 568 12 steps step NNS cord-010119-t1x9gknd 568 13 of of IN cord-010119-t1x9gknd 568 14 cell cell NN cord-010119-t1x9gknd 568 15 migration migration NN cord-010119-t1x9gknd 568 16 , , , cord-010119-t1x9gknd 568 17 we -PRON- PRP cord-010119-t1x9gknd 568 18 aim aim VBP cord-010119-t1x9gknd 568 19 to to TO cord-010119-t1x9gknd 568 20 explore explore VB cord-010119-t1x9gknd 568 21 the the DT cord-010119-t1x9gknd 568 22 role role NN cord-010119-t1x9gknd 568 23 of of IN cord-010119-t1x9gknd 568 24 LeY ley NN cord-010119-t1x9gknd 568 25 in in IN cord-010119-t1x9gknd 568 26 microtubule microtubule NN cord-010119-t1x9gknd 568 27 and and CC cord-010119-t1x9gknd 568 28 cell cell NN cord-010119-t1x9gknd 568 29 migration migration NN cord-010119-t1x9gknd 568 30 using use VBG cord-010119-t1x9gknd 568 31 breast breast NN cord-010119-t1x9gknd 568 32 cancer cancer NN cord-010119-t1x9gknd 568 33 cells cell NNS cord-010119-t1x9gknd 568 34 , , , cord-010119-t1x9gknd 568 35 which which WDT cord-010119-t1x9gknd 568 36 may may MD cord-010119-t1x9gknd 568 37 provide provide VB cord-010119-t1x9gknd 568 38 reference reference NN cord-010119-t1x9gknd 568 39 to to IN cord-010119-t1x9gknd 568 40 clinical clinical JJ cord-010119-t1x9gknd 568 41 study study NN cord-010119-t1x9gknd 568 42 of of IN cord-010119-t1x9gknd 568 43 other other JJ cord-010119-t1x9gknd 568 44 histo histo JJ cord-010119-t1x9gknd 568 45 - - HYPH cord-010119-t1x9gknd 568 46 blood blood NN cord-010119-t1x9gknd 568 47 group group NN cord-010119-t1x9gknd 568 48 antigens antigen NNS cord-010119-t1x9gknd 568 49 and and CC cord-010119-t1x9gknd 568 50 change change VB cord-010119-t1x9gknd 568 51 the the DT cord-010119-t1x9gknd 568 52 way way NN cord-010119-t1x9gknd 568 53 of of IN cord-010119-t1x9gknd 568 54 thinking thinking NN cord-010119-t1x9gknd 568 55 in in IN cord-010119-t1x9gknd 568 56 transfusion transfusion NN cord-010119-t1x9gknd 568 57 practice practice NN cord-010119-t1x9gknd 568 58 . . . cord-010119-t1x9gknd 569 1 Study Study NNP cord-010119-t1x9gknd 569 2 Design Design NNP cord-010119-t1x9gknd 569 3 / / SYM cord-010119-t1x9gknd 569 4 Methods method NNS cord-010119-t1x9gknd 569 5 : : : cord-010119-t1x9gknd 569 6 We -PRON- PRP cord-010119-t1x9gknd 569 7 first first RB cord-010119-t1x9gknd 569 8 manipulate manipulate VBP cord-010119-t1x9gknd 569 9 LeY ley NN cord-010119-t1x9gknd 569 10 expression expression NN cord-010119-t1x9gknd 569 11 in in IN cord-010119-t1x9gknd 569 12 breast breast NN cord-010119-t1x9gknd 569 13 cancer cancer NN cord-010119-t1x9gknd 569 14 cells cell NNS cord-010119-t1x9gknd 569 15 by by IN cord-010119-t1x9gknd 569 16 overexpression overexpression NN cord-010119-t1x9gknd 569 17 or or CC cord-010119-t1x9gknd 569 18 siRNA siRNA NNP cord-010119-t1x9gknd 569 19 knockdown knockdown NN cord-010119-t1x9gknd 569 20 of of IN cord-010119-t1x9gknd 569 21 fucosyltransferases fucosyltransferases NNP cord-010119-t1x9gknd 569 22 , , , cord-010119-t1x9gknd 569 23 and and CC cord-010119-t1x9gknd 569 24 block block NN cord-010119-t1x9gknd 569 25 LeY ley NN cord-010119-t1x9gknd 569 26 activity activity NN cord-010119-t1x9gknd 569 27 in in IN cord-010119-t1x9gknd 569 28 MDA MDA NNP cord-010119-t1x9gknd 569 29 - - HYPH cord-010119-t1x9gknd 569 30 MB231 MB231 NNP cord-010119-t1x9gknd 569 31 cells cell NNS cord-010119-t1x9gknd 569 32 using use VBG cord-010119-t1x9gknd 569 33 anti anti JJ cord-010119-t1x9gknd 569 34 - - JJ cord-010119-t1x9gknd 569 35 LeY ley JJ cord-010119-t1x9gknd 569 36 antibody antibody NN cord-010119-t1x9gknd 569 37 , , , cord-010119-t1x9gknd 569 38 to to TO cord-010119-t1x9gknd 569 39 verify verify VB cord-010119-t1x9gknd 569 40 the the DT cord-010119-t1x9gknd 569 41 effect effect NN cord-010119-t1x9gknd 569 42 of of IN cord-010119-t1x9gknd 569 43 LeY ley NN cord-010119-t1x9gknd 569 44 on on IN cord-010119-t1x9gknd 569 45 cell cell NN cord-010119-t1x9gknd 569 46 migration migration NN cord-010119-t1x9gknd 569 47 . . . cord-010119-t1x9gknd 570 1 Then then RB cord-010119-t1x9gknd 570 2 , , , cord-010119-t1x9gknd 570 3 we -PRON- PRP cord-010119-t1x9gknd 570 4 detect detect VBP cord-010119-t1x9gknd 570 5 acetyl acetyl NN cord-010119-t1x9gknd 570 6 - - HYPH cord-010119-t1x9gknd 570 7 a a DT cord-010119-t1x9gknd 570 8 - - HYPH cord-010119-t1x9gknd 570 9 tubulin tubulin NN cord-010119-t1x9gknd 570 10 level level NN cord-010119-t1x9gknd 570 11 change change NN cord-010119-t1x9gknd 570 12 as as IN cord-010119-t1x9gknd 570 13 microtubule microtubule JJ cord-010119-t1x9gknd 570 14 acetylation acetylation NN cord-010119-t1x9gknd 570 15 is be VBZ cord-010119-t1x9gknd 570 16 a a DT cord-010119-t1x9gknd 570 17 sign sign NN cord-010119-t1x9gknd 570 18 for for IN cord-010119-t1x9gknd 570 19 stability stability NN cord-010119-t1x9gknd 570 20 . . . cord-010119-t1x9gknd 571 1 To to TO cord-010119-t1x9gknd 571 2 establish establish VB cord-010119-t1x9gknd 571 3 the the DT cord-010119-t1x9gknd 571 4 role role NN cord-010119-t1x9gknd 571 5 of of IN cord-010119-t1x9gknd 571 6 LeY ley NN cord-010119-t1x9gknd 571 7 in in IN cord-010119-t1x9gknd 571 8 cell cell NN cord-010119-t1x9gknd 571 9 migration migration NN cord-010119-t1x9gknd 571 10 via via IN cord-010119-t1x9gknd 571 11 microtubule microtubule JJ cord-010119-t1x9gknd 571 12 modification modification NN cord-010119-t1x9gknd 571 13 , , , cord-010119-t1x9gknd 571 14 we -PRON- PRP cord-010119-t1x9gknd 571 15 use use VBP cord-010119-t1x9gknd 571 16 HDAC6 HDAC6 NNS cord-010119-t1x9gknd 571 17 specific specific JJ cord-010119-t1x9gknd 571 18 ( ( -LRB- cord-010119-t1x9gknd 571 19 Tubacin Tubacin NNP cord-010119-t1x9gknd 571 20 ) ) -RRB- cord-010119-t1x9gknd 571 21 and and CC cord-010119-t1x9gknd 571 22 nonspecific nonspecific JJ cord-010119-t1x9gknd 571 23 ( ( -LRB- cord-010119-t1x9gknd 571 24 TSA TSA NNP cord-010119-t1x9gknd 571 25 ) ) -RRB- cord-010119-t1x9gknd 571 26 inhibitors inhibitor NNS cord-010119-t1x9gknd 571 27 to to TO cord-010119-t1x9gknd 571 28 minimize minimize VB cord-010119-t1x9gknd 571 29 deacetylation deacetylation NN cord-010119-t1x9gknd 571 30 of of IN cord-010119-t1x9gknd 571 31 acetyl acetyl NN cord-010119-t1x9gknd 571 32 - - HYPH cord-010119-t1x9gknd 571 33 atubulin atubulin NN cord-010119-t1x9gknd 571 34 and and CC cord-010119-t1x9gknd 571 35 test test VB cord-010119-t1x9gknd 571 36 again again RB cord-010119-t1x9gknd 571 37 the the DT cord-010119-t1x9gknd 571 38 effect effect NN cord-010119-t1x9gknd 571 39 of of IN cord-010119-t1x9gknd 571 40 FUT1 FUT1 NNP cord-010119-t1x9gknd 571 41 overexpression overexpression NN cord-010119-t1x9gknd 571 42 on on IN cord-010119-t1x9gknd 571 43 cell cell NN cord-010119-t1x9gknd 571 44 motility motility NN cord-010119-t1x9gknd 571 45 . . . cord-010119-t1x9gknd 572 1 Results result NNS cord-010119-t1x9gknd 572 2 / / SYM cord-010119-t1x9gknd 572 3 Findings finding NNS cord-010119-t1x9gknd 572 4 : : : cord-010119-t1x9gknd 573 1 FUT1 FUT1 NNP cord-010119-t1x9gknd 573 2 overexpression overexpression NN cord-010119-t1x9gknd 573 3 increases increase VBZ cord-010119-t1x9gknd 573 4 both both CC cord-010119-t1x9gknd 573 5 LeY ley NN cord-010119-t1x9gknd 573 6 expression expression NN cord-010119-t1x9gknd 573 7 and and CC cord-010119-t1x9gknd 573 8 cell cell NN cord-010119-t1x9gknd 573 9 migration migration NN cord-010119-t1x9gknd 573 10 , , , cord-010119-t1x9gknd 573 11 while while IN cord-010119-t1x9gknd 573 12 FUT1 FUT1 NNP cord-010119-t1x9gknd 573 13 knockdown knockdown NN cord-010119-t1x9gknd 573 14 leads lead VBZ cord-010119-t1x9gknd 573 15 to to IN cord-010119-t1x9gknd 573 16 the the DT cord-010119-t1x9gknd 573 17 opposite opposite NN cord-010119-t1x9gknd 573 18 . . . cord-010119-t1x9gknd 574 1 LeY LeY NNP cord-010119-t1x9gknd 574 2 activity activity NN cord-010119-t1x9gknd 574 3 blockade blockade NN cord-010119-t1x9gknd 574 4 by by IN cord-010119-t1x9gknd 574 5 anti anti JJ cord-010119-t1x9gknd 574 6 - - JJ cord-010119-t1x9gknd 574 7 LeY ley JJ cord-010119-t1x9gknd 574 8 antibody antibody NN cord-010119-t1x9gknd 574 9 also also RB cord-010119-t1x9gknd 574 10 significantly significantly RB cord-010119-t1x9gknd 574 11 inhibits inhibit VBZ cord-010119-t1x9gknd 574 12 cell cell NN cord-010119-t1x9gknd 574 13 migration migration NN cord-010119-t1x9gknd 574 14 . . . cord-010119-t1x9gknd 575 1 Western western JJ cord-010119-t1x9gknd 575 2 Blot Blot NNP cord-010119-t1x9gknd 575 3 and and CC cord-010119-t1x9gknd 575 4 Immunostaining Immunostaining NNP cord-010119-t1x9gknd 575 5 results result NNS cord-010119-t1x9gknd 575 6 show show VBP cord-010119-t1x9gknd 575 7 a a DT cord-010119-t1x9gknd 575 8 - - HYPH cord-010119-t1x9gknd 575 9 tubulin tubulin NN cord-010119-t1x9gknd 575 10 acetylation acetylation NN cord-010119-t1x9gknd 575 11 level level NN cord-010119-t1x9gknd 575 12 is be VBZ cord-010119-t1x9gknd 575 13 negatively negatively RB cord-010119-t1x9gknd 575 14 related relate VBN cord-010119-t1x9gknd 575 15 with with IN cord-010119-t1x9gknd 575 16 LeY ley NN cord-010119-t1x9gknd 575 17 expression expression NN cord-010119-t1x9gknd 575 18 . . . cord-010119-t1x9gknd 576 1 Tubacin Tubacin NNP cord-010119-t1x9gknd 576 2 or or CC cord-010119-t1x9gknd 576 3 TSA TSA NNP cord-010119-t1x9gknd 576 4 treatment treatment NN cord-010119-t1x9gknd 576 5 increases increase VBZ cord-010119-t1x9gknd 576 6 the the DT cord-010119-t1x9gknd 576 7 acetyl acetyl NN cord-010119-t1x9gknd 576 8 - - HYPH cord-010119-t1x9gknd 576 9 a a DT cord-010119-t1x9gknd 576 10 - - HYPH cord-010119-t1x9gknd 576 11 tubulin tubulin NN cord-010119-t1x9gknd 576 12 level level NN cord-010119-t1x9gknd 576 13 while while IN cord-010119-t1x9gknd 576 14 inhibits inhibit VBZ cord-010119-t1x9gknd 576 15 cell cell NN cord-010119-t1x9gknd 576 16 migration migration NN cord-010119-t1x9gknd 576 17 ; ; : cord-010119-t1x9gknd 576 18 in in IN cord-010119-t1x9gknd 576 19 the the DT cord-010119-t1x9gknd 576 20 meantime meantime NN cord-010119-t1x9gknd 576 21 , , , cord-010119-t1x9gknd 576 22 the the DT cord-010119-t1x9gknd 576 23 significance significance NN cord-010119-t1x9gknd 576 24 of of IN cord-010119-t1x9gknd 576 25 FUT1 FUT1 NNP cord-010119-t1x9gknd 576 26 overexpression overexpression NN cord-010119-t1x9gknd 576 27 in in IN cord-010119-t1x9gknd 576 28 promoting promote VBG cord-010119-t1x9gknd 576 29 cell cell NN cord-010119-t1x9gknd 576 30 migration migration NN cord-010119-t1x9gknd 576 31 is be VBZ cord-010119-t1x9gknd 576 32 eliminated eliminate VBN cord-010119-t1x9gknd 576 33 . . . cord-010119-t1x9gknd 577 1 Conclusion conclusion NN cord-010119-t1x9gknd 577 2 : : : cord-010119-t1x9gknd 577 3 It -PRON- PRP cord-010119-t1x9gknd 577 4 can can MD cord-010119-t1x9gknd 577 5 be be VB cord-010119-t1x9gknd 577 6 concluded conclude VBN cord-010119-t1x9gknd 577 7 from from IN cord-010119-t1x9gknd 577 8 the the DT cord-010119-t1x9gknd 577 9 results result NNS cord-010119-t1x9gknd 577 10 above above IN cord-010119-t1x9gknd 577 11 that that DT cord-010119-t1x9gknd 577 12 LeY ley NN cord-010119-t1x9gknd 577 13 can can MD cord-010119-t1x9gknd 577 14 promote promote VB cord-010119-t1x9gknd 577 15 cell cell NN cord-010119-t1x9gknd 577 16 migration migration NN cord-010119-t1x9gknd 577 17 via via IN cord-010119-t1x9gknd 577 18 regulation regulation NN cord-010119-t1x9gknd 577 19 of of IN cord-010119-t1x9gknd 577 20 a a DT cord-010119-t1x9gknd 577 21 - - HYPH cord-010119-t1x9gknd 577 22 tubulin tubulin NN cord-010119-t1x9gknd 577 23 acetylation acetylation NN cord-010119-t1x9gknd 577 24 , , , cord-010119-t1x9gknd 577 25 wherein wherein WRB cord-010119-t1x9gknd 577 26 LeY ley NN cord-010119-t1x9gknd 577 27 may may MD cord-010119-t1x9gknd 577 28 have have VB cord-010119-t1x9gknd 577 29 interaction interaction NN cord-010119-t1x9gknd 577 30 with with IN cord-010119-t1x9gknd 577 31 deacetylase deacetylase NN cord-010119-t1x9gknd 577 32 HDAC6 HDAC6 NNS cord-010119-t1x9gknd 577 33 . . . cord-010119-t1x9gknd 578 1 As as IN cord-010119-t1x9gknd 578 2 tumor tumor NN cord-010119-t1x9gknd 578 3 promoter promoter NN cord-010119-t1x9gknd 578 4 , , , cord-010119-t1x9gknd 578 5 HDAC6 HDAC6 NNP cord-010119-t1x9gknd 578 6 becomes become VBZ cord-010119-t1x9gknd 578 7 the the DT cord-010119-t1x9gknd 578 8 target target NN cord-010119-t1x9gknd 578 9 of of IN cord-010119-t1x9gknd 578 10 many many JJ cord-010119-t1x9gknd 578 11 anti anti JJ cord-010119-t1x9gknd 578 12 - - JJ cord-010119-t1x9gknd 578 13 cancer cancer JJ cord-010119-t1x9gknd 578 14 drugs drug NNS cord-010119-t1x9gknd 578 15 . . . cord-010119-t1x9gknd 579 1 We -PRON- PRP cord-010119-t1x9gknd 579 2 demonstrated demonstrate VBD cord-010119-t1x9gknd 579 3 the the DT cord-010119-t1x9gknd 579 4 potential potential JJ cord-010119-t1x9gknd 579 5 association association NN cord-010119-t1x9gknd 579 6 of of IN cord-010119-t1x9gknd 579 7 LeY LeY NNP cord-010119-t1x9gknd 579 8 and and CC cord-010119-t1x9gknd 579 9 HDAC6 HDAC6 NNP cord-010119-t1x9gknd 579 10 function function VBP cord-010119-t1x9gknd 579 11 in in IN cord-010119-t1x9gknd 579 12 this this DT cord-010119-t1x9gknd 579 13 study study NN cord-010119-t1x9gknd 579 14 . . . cord-010119-t1x9gknd 580 1 Many many JJ cord-010119-t1x9gknd 580 2 blood blood NN cord-010119-t1x9gknd 580 3 group group NN cord-010119-t1x9gknd 580 4 antigens antigen NNS cord-010119-t1x9gknd 580 5 are be VBP cord-010119-t1x9gknd 580 6 also also RB cord-010119-t1x9gknd 580 7 carbohydrate carbohydrate NN cord-010119-t1x9gknd 580 8 chains chain NNS cord-010119-t1x9gknd 580 9 , , , cord-010119-t1x9gknd 580 10 which which WDT cord-010119-t1x9gknd 580 11 are be VBP cord-010119-t1x9gknd 580 12 not not RB cord-010119-t1x9gknd 580 13 only only RB cord-010119-t1x9gknd 580 14 critical critical JJ cord-010119-t1x9gknd 580 15 in in IN cord-010119-t1x9gknd 580 16 blood blood NN cord-010119-t1x9gknd 580 17 group group NN cord-010119-t1x9gknd 580 18 determination determination NN cord-010119-t1x9gknd 580 19 , , , cord-010119-t1x9gknd 580 20 compatible compatible JJ cord-010119-t1x9gknd 580 21 transfusion transfusion NN cord-010119-t1x9gknd 580 22 and and CC cord-010119-t1x9gknd 580 23 immunological immunological JJ cord-010119-t1x9gknd 580 24 reaction reaction NN cord-010119-t1x9gknd 580 25 , , , cord-010119-t1x9gknd 580 26 but but CC cord-010119-t1x9gknd 580 27 may may MD cord-010119-t1x9gknd 580 28 also also RB cord-010119-t1x9gknd 580 29 have have VB cord-010119-t1x9gknd 580 30 an an DT cord-010119-t1x9gknd 580 31 effect effect NN cord-010119-t1x9gknd 580 32 in in IN cord-010119-t1x9gknd 580 33 the the DT cord-010119-t1x9gknd 580 34 initiation initiation NN cord-010119-t1x9gknd 580 35 and and CC cord-010119-t1x9gknd 580 36 development development NN cord-010119-t1x9gknd 580 37 of of IN cord-010119-t1x9gknd 580 38 diseases disease NNS cord-010119-t1x9gknd 580 39 as as IN cord-010119-t1x9gknd 580 40 tumor tumor NN cord-010119-t1x9gknd 580 41 , , , cord-010119-t1x9gknd 580 42 similar similar JJ cord-010119-t1x9gknd 580 43 to to IN cord-010119-t1x9gknd 580 44 LeY ley NN cord-010119-t1x9gknd 580 45 ; ; : cord-010119-t1x9gknd 580 46 they -PRON- PRP cord-010119-t1x9gknd 580 47 can can MD cord-010119-t1x9gknd 580 48 even even RB cord-010119-t1x9gknd 580 49 be be VB cord-010119-t1x9gknd 580 50 components component NNS cord-010119-t1x9gknd 580 51 in in IN cord-010119-t1x9gknd 580 52 a a DT cord-010119-t1x9gknd 580 53 network network NN cord-010119-t1x9gknd 580 54 with with IN cord-010119-t1x9gknd 580 55 other other JJ cord-010119-t1x9gknd 580 56 important important JJ cord-010119-t1x9gknd 580 57 molecules molecule NNS cord-010119-t1x9gknd 580 58 and and CC cord-010119-t1x9gknd 580 59 contribute contribute VB cord-010119-t1x9gknd 580 60 to to IN cord-010119-t1x9gknd 580 61 the the DT cord-010119-t1x9gknd 580 62 destiny destiny NN cord-010119-t1x9gknd 580 63 of of IN cord-010119-t1x9gknd 580 64 diseases disease NNS cord-010119-t1x9gknd 580 65 . . . cord-010119-t1x9gknd 581 1 Transfusion transfusion NN cord-010119-t1x9gknd 581 2 of of IN cord-010119-t1x9gknd 581 3 blood blood NN cord-010119-t1x9gknd 581 4 products product NNS cord-010119-t1x9gknd 581 5 is be VBZ cord-010119-t1x9gknd 581 6 frequently frequently RB cord-010119-t1x9gknd 581 7 needed need VBN cord-010119-t1x9gknd 581 8 by by IN cord-010119-t1x9gknd 581 9 tumor tumor NN cord-010119-t1x9gknd 581 10 patients patient NNS cord-010119-t1x9gknd 581 11 . . . cord-010119-t1x9gknd 582 1 Most Most JJS cord-010119-t1x9gknd 582 2 attention attention NN cord-010119-t1x9gknd 582 3 is be VBZ cord-010119-t1x9gknd 582 4 focused focus VBN cord-010119-t1x9gknd 582 5 on on IN cord-010119-t1x9gknd 582 6 the the DT cord-010119-t1x9gknd 582 7 search search NN cord-010119-t1x9gknd 582 8 of of IN cord-010119-t1x9gknd 582 9 compatible compatible JJ cord-010119-t1x9gknd 582 10 blood blood NN cord-010119-t1x9gknd 582 11 for for IN cord-010119-t1x9gknd 582 12 reducing reduce VBG cord-010119-t1x9gknd 582 13 transfusion transfusion NN cord-010119-t1x9gknd 582 14 reaction reaction NN cord-010119-t1x9gknd 582 15 . . . cord-010119-t1x9gknd 583 1 However however RB cord-010119-t1x9gknd 583 2 , , , cord-010119-t1x9gknd 583 3 it -PRON- PRP cord-010119-t1x9gknd 583 4 may may MD cord-010119-t1x9gknd 583 5 lower lower VB cord-010119-t1x9gknd 583 6 the the DT cord-010119-t1x9gknd 583 7 chance chance NN cord-010119-t1x9gknd 583 8 for for IN cord-010119-t1x9gknd 583 9 the the DT cord-010119-t1x9gknd 583 10 disease disease NN cord-010119-t1x9gknd 583 11 to to TO cord-010119-t1x9gknd 583 12 advance advance VB cord-010119-t1x9gknd 583 13 to to TO cord-010119-t1x9gknd 583 14 take take VB cord-010119-t1x9gknd 583 15 account account NN cord-010119-t1x9gknd 584 1 Background Background NNP cord-010119-t1x9gknd 584 2 / / SYM cord-010119-t1x9gknd 584 3 Case Case NNP cord-010119-t1x9gknd 584 4 Studies Studies NNPS cord-010119-t1x9gknd 584 5 : : : cord-010119-t1x9gknd 585 1 Reducing reduce VBG cord-010119-t1x9gknd 585 2 the the DT cord-010119-t1x9gknd 585 3 risk risk NN cord-010119-t1x9gknd 585 4 of of IN cord-010119-t1x9gknd 585 5 bacterial bacterial JJ cord-010119-t1x9gknd 585 6 contamination contamination NN cord-010119-t1x9gknd 585 7 in in IN cord-010119-t1x9gknd 585 8 platelet platelet NN cord-010119-t1x9gknd 585 9 ( ( -LRB- cord-010119-t1x9gknd 585 10 PLT PLT NNP cord-010119-t1x9gknd 585 11 ) ) -RRB- cord-010119-t1x9gknd 585 12 products product NNS cord-010119-t1x9gknd 585 13 is be VBZ cord-010119-t1x9gknd 585 14 of of IN cord-010119-t1x9gknd 585 15 great great JJ cord-010119-t1x9gknd 585 16 concern concern NN cord-010119-t1x9gknd 585 17 since since IN cord-010119-t1x9gknd 585 18 PLT PLT NNP cord-010119-t1x9gknd 585 19 storage storage NN cord-010119-t1x9gknd 585 20 occurs occur VBZ cord-010119-t1x9gknd 585 21 at at IN cord-010119-t1x9gknd 585 22 room room NN cord-010119-t1x9gknd 585 23 temperature temperature NN cord-010119-t1x9gknd 585 24 ( ( -LRB- cord-010119-t1x9gknd 585 25 RT RT NNP cord-010119-t1x9gknd 585 26 ) ) -RRB- cord-010119-t1x9gknd 585 27 . . . cord-010119-t1x9gknd 586 1 Pathogen pathogen NN cord-010119-t1x9gknd 586 2 reduction reduction NN cord-010119-t1x9gknd 586 3 technologies technology NNS cord-010119-t1x9gknd 586 4 ( ( -LRB- cord-010119-t1x9gknd 586 5 PRT PRT NNP cord-010119-t1x9gknd 586 6 ) ) -RRB- cord-010119-t1x9gknd 586 7 were be VBD cord-010119-t1x9gknd 586 8 developed develop VBN cord-010119-t1x9gknd 586 9 to to TO cord-010119-t1x9gknd 586 10 inactivate inactivate VB cord-010119-t1x9gknd 586 11 pathogens pathogen NNS cord-010119-t1x9gknd 586 12 prior prior RB cord-010119-t1x9gknd 586 13 to to IN cord-010119-t1x9gknd 586 14 transfusion transfusion NN cord-010119-t1x9gknd 586 15 ; ; : cord-010119-t1x9gknd 586 16 however however RB cord-010119-t1x9gknd 586 17 , , , cord-010119-t1x9gknd 586 18 studies study NNS cord-010119-t1x9gknd 586 19 have have VBP cord-010119-t1x9gknd 586 20 shown show VBN cord-010119-t1x9gknd 586 21 that that IN cord-010119-t1x9gknd 586 22 PRT PRT NNP cord-010119-t1x9gknd 586 23 may may MD cord-010119-t1x9gknd 586 24 damage damage VB cord-010119-t1x9gknd 586 25 PLTs plt NNS cord-010119-t1x9gknd 586 26 over over IN cord-010119-t1x9gknd 586 27 the the DT cord-010119-t1x9gknd 586 28 course course NN cord-010119-t1x9gknd 586 29 of of IN cord-010119-t1x9gknd 586 30 extended extended JJ cord-010119-t1x9gknd 586 31 storage storage NN cord-010119-t1x9gknd 586 32 at at IN cord-010119-t1x9gknd 586 33 RT RT NNP cord-010119-t1x9gknd 586 34 resulting result VBG cord-010119-t1x9gknd 586 35 in in IN cord-010119-t1x9gknd 586 36 a a DT cord-010119-t1x9gknd 586 37 greater great JJR cord-010119-t1x9gknd 586 38 loss loss NN cord-010119-t1x9gknd 586 39 of of IN cord-010119-t1x9gknd 586 40 function function NN cord-010119-t1x9gknd 586 41 than than IN cord-010119-t1x9gknd 586 42 what what WP cord-010119-t1x9gknd 586 43 is be VBZ cord-010119-t1x9gknd 586 44 normally normally RB cord-010119-t1x9gknd 586 45 concomitant concomitant JJ cord-010119-t1x9gknd 586 46 with with IN cord-010119-t1x9gknd 586 47 platelet platelet NN cord-010119-t1x9gknd 586 48 storage storage NN cord-010119-t1x9gknd 586 49 lesion lesion NN cord-010119-t1x9gknd 586 50 . . . cord-010119-t1x9gknd 587 1 Storage storage NN cord-010119-t1x9gknd 587 2 of of IN cord-010119-t1x9gknd 587 3 PLTs plt NNS cord-010119-t1x9gknd 587 4 in in IN cord-010119-t1x9gknd 587 5 platelet platelet NN cord-010119-t1x9gknd 587 6 additive additive NN cord-010119-t1x9gknd 587 7 solution solution NN cord-010119-t1x9gknd 587 8 ( ( -LRB- cord-010119-t1x9gknd 587 9 PAS pas NN cord-010119-t1x9gknd 587 10 ) ) -RRB- cord-010119-t1x9gknd 587 11 at at IN cord-010119-t1x9gknd 587 12 48C 48c CD cord-010119-t1x9gknd 587 13 helps help VBZ cord-010119-t1x9gknd 587 14 to to TO cord-010119-t1x9gknd 587 15 preserve preserve VB cord-010119-t1x9gknd 587 16 PLT PLT NNP cord-010119-t1x9gknd 587 17 function function NN cord-010119-t1x9gknd 587 18 and and CC cord-010119-t1x9gknd 587 19 reduces reduce VBZ cord-010119-t1x9gknd 587 20 the the DT cord-010119-t1x9gknd 587 21 risk risk NN cord-010119-t1x9gknd 587 22 of of IN cord-010119-t1x9gknd 587 23 contamination contamination NN cord-010119-t1x9gknd 587 24 . . . cord-010119-t1x9gknd 588 1 In in IN cord-010119-t1x9gknd 588 2 this this DT cord-010119-t1x9gknd 588 3 study study NN cord-010119-t1x9gknd 588 4 , , , cord-010119-t1x9gknd 588 5 we -PRON- PRP cord-010119-t1x9gknd 588 6 established establish VBD cord-010119-t1x9gknd 588 7 the the DT cord-010119-t1x9gknd 588 8 impact impact NN cord-010119-t1x9gknd 588 9 of of IN cord-010119-t1x9gknd 588 10 PRT PRT NNP cord-010119-t1x9gknd 588 11 performed perform VBN cord-010119-t1x9gknd 588 12 after after IN cord-010119-t1x9gknd 588 13 long long JJ cord-010119-t1x9gknd 588 14 - - HYPH cord-010119-t1x9gknd 588 15 term term NN cord-010119-t1x9gknd 588 16 coldstorage coldstorage NN cord-010119-t1x9gknd 588 17 of of IN cord-010119-t1x9gknd 588 18 PLTs plt NNS cord-010119-t1x9gknd 588 19 in in IN cord-010119-t1x9gknd 588 20 PAS pas NN cord-010119-t1x9gknd 588 21 , , , cord-010119-t1x9gknd 588 22 instead instead RB cord-010119-t1x9gknd 588 23 of of IN cord-010119-t1x9gknd 588 24 before before IN cord-010119-t1x9gknd 588 25 storage storage NN cord-010119-t1x9gknd 588 26 , , , cord-010119-t1x9gknd 588 27 on on IN cord-010119-t1x9gknd 588 28 PLT PLT NNP cord-010119-t1x9gknd 588 29 function function NN cord-010119-t1x9gknd 588 30 , , , cord-010119-t1x9gknd 588 31 mitochondrial mitochondrial JJ cord-010119-t1x9gknd 588 32 respiration respiration NN cord-010119-t1x9gknd 588 33 , , , cord-010119-t1x9gknd 588 34 and and CC cord-010119-t1x9gknd 588 35 cell cell NN cord-010119-t1x9gknd 588 36 death death NN cord-010119-t1x9gknd 588 37 parameters parameter NNS cord-010119-t1x9gknd 588 38 . . . cord-010119-t1x9gknd 589 1 Study Study NNP cord-010119-t1x9gknd 589 2 Design Design NNP cord-010119-t1x9gknd 589 3 / / SYM cord-010119-t1x9gknd 589 4 Method method NN cord-010119-t1x9gknd 589 5 : : : cord-010119-t1x9gknd 589 6 PLT PLT NNP cord-010119-t1x9gknd 589 7 units unit NNS cord-010119-t1x9gknd 589 8 were be VBD cord-010119-t1x9gknd 589 9 collected collect VBN cord-010119-t1x9gknd 589 10 in in IN cord-010119-t1x9gknd 589 11 PAS pas NN cord-010119-t1x9gknd 589 12 ( ( -LRB- cord-010119-t1x9gknd 589 13 n53 n53 NN cord-010119-t1x9gknd 589 14 ) ) -RRB- cord-010119-t1x9gknd 589 15 and and CC cord-010119-t1x9gknd 589 16 stored store VBN cord-010119-t1x9gknd 589 17 at at IN cord-010119-t1x9gknd 589 18 48C 48c CD cord-010119-t1x9gknd 589 19 for for IN cord-010119-t1x9gknd 589 20 up up IN cord-010119-t1x9gknd 589 21 to to TO cord-010119-t1x9gknd 589 22 10 10 CD cord-010119-t1x9gknd 589 23 days day NNS cord-010119-t1x9gknd 589 24 . . . cord-010119-t1x9gknd 590 1 After after IN cord-010119-t1x9gknd 590 2 this this DT cord-010119-t1x9gknd 590 3 time time NN cord-010119-t1x9gknd 590 4 period period NN cord-010119-t1x9gknd 590 5 , , , cord-010119-t1x9gknd 590 6 the the DT cord-010119-t1x9gknd 590 7 bag bag NN cord-010119-t1x9gknd 590 8 was be VBD cord-010119-t1x9gknd 590 9 treated treat VBN cord-010119-t1x9gknd 590 10 using use VBG cord-010119-t1x9gknd 590 11 Mirasol Mirasol NNP cord-010119-t1x9gknd 590 12 PRT PRT NNP cord-010119-t1x9gknd 590 13 ( ( -LRB- cord-010119-t1x9gknd 590 14 riboflavin riboflavin NN cord-010119-t1x9gknd 590 15 and and CC cord-010119-t1x9gknd 590 16 UV uv NN cord-010119-t1x9gknd 590 17 ) ) -RRB- cord-010119-t1x9gknd 590 18 . . . cord-010119-t1x9gknd 591 1 Samples sample NNS cord-010119-t1x9gknd 591 2 were be VBD cord-010119-t1x9gknd 591 3 obtained obtain VBN cord-010119-t1x9gknd 591 4 and and CC cord-010119-t1x9gknd 591 5 tested test VBN cord-010119-t1x9gknd 591 6 on on IN cord-010119-t1x9gknd 591 7 the the DT cord-010119-t1x9gknd 591 8 day day NN cord-010119-t1x9gknd 591 9 of of IN cord-010119-t1x9gknd 591 10 collection collection NN cord-010119-t1x9gknd 591 11 ( ( -LRB- cord-010119-t1x9gknd 591 12 baseline baseline NN cord-010119-t1x9gknd 591 13 , , , cord-010119-t1x9gknd 591 14 BL BL NNP cord-010119-t1x9gknd 591 15 ) ) -RRB- cord-010119-t1x9gknd 591 16 , , , cord-010119-t1x9gknd 591 17 pre pre JJ cord-010119-t1x9gknd 591 18 - - JJ cord-010119-t1x9gknd 591 19 Mirasol mirasol JJ cord-010119-t1x9gknd 591 20 ( ( -LRB- cord-010119-t1x9gknd 591 21 PRE PRE NNP cord-010119-t1x9gknd 591 22 ) ) -RRB- cord-010119-t1x9gknd 591 23 , , , cord-010119-t1x9gknd 591 24 post post JJ cord-010119-t1x9gknd 591 25 - - JJ cord-010119-t1x9gknd 591 26 Mirasol mirasol JJ cord-010119-t1x9gknd 591 27 ( ( -LRB- cord-010119-t1x9gknd 591 28 POST POST NNP cord-010119-t1x9gknd 591 29 ) ) -RRB- cord-010119-t1x9gknd 591 30 , , , cord-010119-t1x9gknd 591 31 and and CC cord-010119-t1x9gknd 591 32 30 30 CD cord-010119-t1x9gknd 591 33 minutes minute NNS cord-010119-t1x9gknd 591 34 post post NN cord-010119-t1x9gknd 591 35 - - JJ cord-010119-t1x9gknd 591 36 Mirasol Mirasol NNP cord-010119-t1x9gknd 591 37 . . . cord-010119-t1x9gknd 592 1 Aggregometry Aggregometry NNP cord-010119-t1x9gknd 592 2 ( ( -LRB- cord-010119-t1x9gknd 592 3 ADP ADP NNP cord-010119-t1x9gknd 592 4 , , , cord-010119-t1x9gknd 592 5 Collagen Collagen NNP cord-010119-t1x9gknd 592 6 , , , cord-010119-t1x9gknd 592 7 TRAP TRAP NNP cord-010119-t1x9gknd 592 8 ) ) -RRB- cord-010119-t1x9gknd 592 9 , , , cord-010119-t1x9gknd 592 10 ROTEM ROTEM NNP cord-010119-t1x9gknd 592 11 , , , cord-010119-t1x9gknd 592 12 flow flow NN cord-010119-t1x9gknd 592 13 cytometry cytometry NN cord-010119-t1x9gknd 592 14 ( ( -LRB- cord-010119-t1x9gknd 592 15 CD62P cd62p NN cord-010119-t1x9gknd 592 16 [ [ -LRB- cord-010119-t1x9gknd 592 17 P P NNP cord-010119-t1x9gknd 592 18 - - : cord-010119-t1x9gknd 592 19 Selectin Selectin NNP cord-010119-t1x9gknd 592 20 ] ] -RRB- cord-010119-t1x9gknd 592 21 , , , cord-010119-t1x9gknd 592 22 lactadherin lactadherin JJ cord-010119-t1x9gknd 592 23 [ [ -LRB- cord-010119-t1x9gknd 592 24 PS PS NNP cord-010119-t1x9gknd 592 25 ] ] -RRB- cord-010119-t1x9gknd 592 26 , , , cord-010119-t1x9gknd 592 27 , , , cord-010119-t1x9gknd 592 28 and and CC cord-010119-t1x9gknd 592 29 GPIb GPIb NNP cord-010119-t1x9gknd 592 30 ) ) -RRB- cord-010119-t1x9gknd 592 31 , , , cord-010119-t1x9gknd 592 32 high high JJ cord-010119-t1x9gknd 592 33 - - HYPH cord-010119-t1x9gknd 592 34 resolution resolution NN cord-010119-t1x9gknd 592 35 respirometry respirometry NN cord-010119-t1x9gknd 592 36 ( ( -LRB- cord-010119-t1x9gknd 592 37 Oroboros Oroboros NNP cord-010119-t1x9gknd 592 38 ) ) -RRB- cord-010119-t1x9gknd 592 39 , , , cord-010119-t1x9gknd 592 40 and and CC cord-010119-t1x9gknd 592 41 imaging image VBG cord-010119-t1x9gknd 592 42 flow flow NN cord-010119-t1x9gknd 592 43 cytometry cytometry NN cord-010119-t1x9gknd 592 44 ( ( -LRB- cord-010119-t1x9gknd 592 45 Amnis Amnis NNP cord-010119-t1x9gknd 592 46 ) ) -RRB- cord-010119-t1x9gknd 592 47 were be VBD cord-010119-t1x9gknd 592 48 used use VBN cord-010119-t1x9gknd 592 49 for for IN cord-010119-t1x9gknd 592 50 analysis analysis NN cord-010119-t1x9gknd 592 51 . . . cord-010119-t1x9gknd 593 1 Data datum NNS cord-010119-t1x9gknd 593 2 are be VBP cord-010119-t1x9gknd 593 3 reported report VBN cord-010119-t1x9gknd 593 4 as as IN cord-010119-t1x9gknd 593 5 means6SEM means6SEM NNP cord-010119-t1x9gknd 593 6 , , , cord-010119-t1x9gknd 593 7 and and CC cord-010119-t1x9gknd 593 8 paired pair VBD cord-010119-t1x9gknd 593 9 student student NN cord-010119-t1x9gknd 593 10 's 's POS cord-010119-t1x9gknd 593 11 t t NN cord-010119-t1x9gknd 593 12 - - HYPH cord-010119-t1x9gknd 593 13 tests test NNS cord-010119-t1x9gknd 593 14 were be VBD cord-010119-t1x9gknd 593 15 used use VBN cord-010119-t1x9gknd 593 16 to to TO cord-010119-t1x9gknd 593 17 determine determine VB cord-010119-t1x9gknd 593 18 statistical statistical JJ cord-010119-t1x9gknd 593 19 significance significance NN cord-010119-t1x9gknd 593 20 ( ( -LRB- cord-010119-t1x9gknd 593 21 p<0.05 p<0.05 CD cord-010119-t1x9gknd 593 22 ) ) -RRB- cord-010119-t1x9gknd 593 23 . . . cord-010119-t1x9gknd 594 1 Results/ Results/ . cord-010119-t1x9gknd 595 1 Finding finding NN cord-010119-t1x9gknd 595 2 : : : cord-010119-t1x9gknd 596 1 On on IN cord-010119-t1x9gknd 596 2 Day Day NNP cord-010119-t1x9gknd 596 3 10 10 CD cord-010119-t1x9gknd 596 4 , , , cord-010119-t1x9gknd 596 5 P P NNP cord-010119-t1x9gknd 596 6 - - HYPH cord-010119-t1x9gknd 596 7 Selectin Selectin NNP cord-010119-t1x9gknd 596 8 levels level NNS cord-010119-t1x9gknd 596 9 were be VBD cord-010119-t1x9gknd 596 10 significantly significantly RB cord-010119-t1x9gknd 596 11 higher high JJR cord-010119-t1x9gknd 596 12 in in IN cord-010119-t1x9gknd 596 13 PRE PRE NNP cord-010119-t1x9gknd 596 14 than than IN cord-010119-t1x9gknd 596 15 BL BL NNP cord-010119-t1x9gknd 596 16 ( ( -LRB- cord-010119-t1x9gknd 596 17 p50.03 p50.03 NNP cord-010119-t1x9gknd 596 18 ) ) -RRB- cord-010119-t1x9gknd 596 19 . . . cord-010119-t1x9gknd 597 1 Mirasol Mirasol NNP cord-010119-t1x9gknd 597 2 treatment treatment NN cord-010119-t1x9gknd 597 3 caused cause VBD cord-010119-t1x9gknd 597 4 a a DT cord-010119-t1x9gknd 597 5 significant significant JJ cord-010119-t1x9gknd 597 6 increase increase NN cord-010119-t1x9gknd 597 7 in in IN cord-010119-t1x9gknd 597 8 PAC-1 pac-1 JJ cord-010119-t1x9gknd 597 9 expression expression NN cord-010119-t1x9gknd 597 10 compared compare VBN cord-010119-t1x9gknd 597 11 to to IN cord-010119-t1x9gknd 597 12 PRE pre VB cord-010119-t1x9gknd 597 13 ( ( -LRB- cord-010119-t1x9gknd 597 14 PRE pre VB cord-010119-t1x9gknd 597 15 : : : cord-010119-t1x9gknd 597 16 10.5 10.5 CD cord-010119-t1x9gknd 597 17 6 6 CD cord-010119-t1x9gknd 597 18 3.1 3.1 CD cord-010119-t1x9gknd 597 19 % % NN cord-010119-t1x9gknd 597 20 , , , cord-010119-t1x9gknd 597 21 POST POST NNP cord-010119-t1x9gknd 597 22 : : : cord-010119-t1x9gknd 597 23 28.1 28.1 CD cord-010119-t1x9gknd 597 24 6 6 CD cord-010119-t1x9gknd 597 25 4.7 4.7 CD cord-010119-t1x9gknd 597 26 % % NN cord-010119-t1x9gknd 597 27 ; ; : cord-010119-t1x9gknd 597 28 p50.04 p50.04 NNP cord-010119-t1x9gknd 597 29 ) ) -RRB- cord-010119-t1x9gknd 597 30 , , , cord-010119-t1x9gknd 597 31 which which WDT cord-010119-t1x9gknd 597 32 remained remain VBD cord-010119-t1x9gknd 597 33 after after IN cord-010119-t1x9gknd 597 34 incubation incubation NN cord-010119-t1x9gknd 597 35 . . . cord-010119-t1x9gknd 598 1 A a DT cord-010119-t1x9gknd 598 2 significant significant JJ cord-010119-t1x9gknd 598 3 drop drop NN cord-010119-t1x9gknd 598 4 in in IN cord-010119-t1x9gknd 598 5 both both CC cord-010119-t1x9gknd 598 6 Collagen Collagen NNP cord-010119-t1x9gknd 598 7 and and CC cord-010119-t1x9gknd 598 8 TRAP trap NN cord-010119-t1x9gknd 598 9 aggregation aggregation NN cord-010119-t1x9gknd 598 10 was be VBD cord-010119-t1x9gknd 598 11 observed observe VBN cord-010119-t1x9gknd 598 12 in in IN cord-010119-t1x9gknd 598 13 POST POST NNP cord-010119-t1x9gknd 598 14 samples sample NNS cord-010119-t1x9gknd 598 15 compared compare VBN cord-010119-t1x9gknd 598 16 to to IN cord-010119-t1x9gknd 598 17 PRE PRE NNP cord-010119-t1x9gknd 598 18 , , , cord-010119-t1x9gknd 598 19 but but CC cord-010119-t1x9gknd 598 20 ADP ADP NNP cord-010119-t1x9gknd 598 21 aggregation aggregation NN cord-010119-t1x9gknd 598 22 response response NN cord-010119-t1x9gknd 598 23 was be VBD cord-010119-t1x9gknd 598 24 preserved preserve VBN cord-010119-t1x9gknd 598 25 . . . cord-010119-t1x9gknd 599 1 No no DT cord-010119-t1x9gknd 599 2 differences difference NNS cord-010119-t1x9gknd 599 3 in in IN cord-010119-t1x9gknd 599 4 P P NNP cord-010119-t1x9gknd 599 5 - - : cord-010119-t1x9gknd 599 6 Selectin Selectin NNP cord-010119-t1x9gknd 599 7 , , , cord-010119-t1x9gknd 599 8 GPIb gpib NN cord-010119-t1x9gknd 599 9 expression expression NN cord-010119-t1x9gknd 599 10 , , , cord-010119-t1x9gknd 599 11 and and CC cord-010119-t1x9gknd 599 12 mitochondrial mitochondrial JJ cord-010119-t1x9gknd 599 13 respiration respiration NN cord-010119-t1x9gknd 599 14 were be VBD cord-010119-t1x9gknd 599 15 observed observe VBN cord-010119-t1x9gknd 599 16 between between IN cord-010119-t1x9gknd 599 17 PRE PRE NNP cord-010119-t1x9gknd 599 18 and and CC cord-010119-t1x9gknd 599 19 POST POST NNP cord-010119-t1x9gknd 599 20 samples sample NNS cord-010119-t1x9gknd 599 21 . . . cord-010119-t1x9gknd 600 1 POST-30 post-30 JJ cord-010119-t1x9gknd 600 2 samples sample NNS cord-010119-t1x9gknd 600 3 displayed display VBD cord-010119-t1x9gknd 600 4 significantly significantly RB cord-010119-t1x9gknd 600 5 less less JJR cord-010119-t1x9gknd 600 6 function function NN cord-010119-t1x9gknd 600 7 , , , cord-010119-t1x9gknd 600 8 higher high JJR cord-010119-t1x9gknd 600 9 activation activation NN cord-010119-t1x9gknd 600 10 levels level NNS cord-010119-t1x9gknd 600 11 , , , cord-010119-t1x9gknd 600 12 and and CC cord-010119-t1x9gknd 600 13 lower low JJR cord-010119-t1x9gknd 600 14 mitochondrial mitochondrial JJ cord-010119-t1x9gknd 600 15 respiration respiration NN cord-010119-t1x9gknd 600 16 compared compare VBN cord-010119-t1x9gknd 600 17 to to IN cord-010119-t1x9gknd 600 18 PRE PRE NNP cord-010119-t1x9gknd 600 19 and and CC cord-010119-t1x9gknd 600 20 POST POST NNP cord-010119-t1x9gknd 600 21 . . . cord-010119-t1x9gknd 601 1 Conclusion conclusion NN cord-010119-t1x9gknd 601 2 : : : cord-010119-t1x9gknd 601 3 PRT PRT NNP cord-010119-t1x9gknd 601 4 treatment treatment NN cord-010119-t1x9gknd 601 5 of of IN cord-010119-t1x9gknd 601 6 PLT PLT NNP cord-010119-t1x9gknd 601 7 units unit NNS cord-010119-t1x9gknd 601 8 in in IN cord-010119-t1x9gknd 601 9 PAS PAS NNP cord-010119-t1x9gknd 601 10 after after IN cord-010119-t1x9gknd 601 11 10 10 CD cord-010119-t1x9gknd 601 12 day day NN cord-010119-t1x9gknd 601 13 storage storage NN cord-010119-t1x9gknd 601 14 at at IN cord-010119-t1x9gknd 601 15 48C 48c CD cord-010119-t1x9gknd 601 16 presents present VBZ cord-010119-t1x9gknd 601 17 a a DT cord-010119-t1x9gknd 601 18 unique unique JJ cord-010119-t1x9gknd 601 19 alternative alternative NN cord-010119-t1x9gknd 601 20 to to IN cord-010119-t1x9gknd 601 21 PRT PRT NNP cord-010119-t1x9gknd 601 22 treatment treatment NN cord-010119-t1x9gknd 601 23 of of IN cord-010119-t1x9gknd 601 24 PLTs plt NNS cord-010119-t1x9gknd 601 25 prior prior RB cord-010119-t1x9gknd 601 26 to to IN cord-010119-t1x9gknd 601 27 RT RT NNP cord-010119-t1x9gknd 601 28 storage storage NN cord-010119-t1x9gknd 601 29 . . . cord-010119-t1x9gknd 602 1 In in IN cord-010119-t1x9gknd 602 2 addition addition NN cord-010119-t1x9gknd 602 3 to to IN cord-010119-t1x9gknd 602 4 providing provide VBG cord-010119-t1x9gknd 602 5 a a DT cord-010119-t1x9gknd 602 6 lower low JJR cord-010119-t1x9gknd 602 7 risk risk NN cord-010119-t1x9gknd 602 8 of of IN cord-010119-t1x9gknd 602 9 bacterial bacterial JJ cord-010119-t1x9gknd 602 10 contamination contamination NN cord-010119-t1x9gknd 602 11 , , , cord-010119-t1x9gknd 602 12 48C 48c CD cord-010119-t1x9gknd 602 13 - - HYPH cord-010119-t1x9gknd 602 14 stored store VBN cord-010119-t1x9gknd 602 15 PAS pas NN cord-010119-t1x9gknd 602 16 PLTs plt NNS cord-010119-t1x9gknd 602 17 may may MD cord-010119-t1x9gknd 602 18 provide provide VB cord-010119-t1x9gknd 602 19 better well JJR cord-010119-t1x9gknd 602 20 preservation preservation NN cord-010119-t1x9gknd 602 21 of of IN cord-010119-t1x9gknd 602 22 hemostatic hemostatic JJ cord-010119-t1x9gknd 602 23 function function NN cord-010119-t1x9gknd 602 24 than than IN cord-010119-t1x9gknd 602 25 standard standard JJ cord-010119-t1x9gknd 602 26 - - HYPH cord-010119-t1x9gknd 602 27 of of IN cord-010119-t1x9gknd 602 28 - - HYPH cord-010119-t1x9gknd 602 29 care care NN cord-010119-t1x9gknd 602 30 RT RT NNP cord-010119-t1x9gknd 602 31 PLTs plt NNS cord-010119-t1x9gknd 602 32 , , , cord-010119-t1x9gknd 602 33 even even RB cord-010119-t1x9gknd 602 34 after after IN cord-010119-t1x9gknd 602 35 Mirasol Mirasol NNP cord-010119-t1x9gknd 602 36 PRT PRT NNP cord-010119-t1x9gknd 602 37 treatment treatment NN cord-010119-t1x9gknd 602 38 . . . cord-010119-t1x9gknd 603 1 However however RB cord-010119-t1x9gknd 603 2 , , , cord-010119-t1x9gknd 603 3 we -PRON- PRP cord-010119-t1x9gknd 603 4 show show VBP cord-010119-t1x9gknd 603 5 here here RB cord-010119-t1x9gknd 603 6 that that IN cord-010119-t1x9gknd 603 7 Mirasol Mirasol NNP cord-010119-t1x9gknd 603 8 PRT PRT NNP cord-010119-t1x9gknd 603 9 of of IN cord-010119-t1x9gknd 603 10 Day Day NNP cord-010119-t1x9gknd 603 11 10 10 CD cord-010119-t1x9gknd 603 12 4C 4c CD cord-010119-t1x9gknd 603 13 - - HYPH cord-010119-t1x9gknd 603 14 stored store VBN cord-010119-t1x9gknd 603 15 PAS pas NN cord-010119-t1x9gknd 603 16 PLTs plt NNS cord-010119-t1x9gknd 603 17 followed follow VBN cord-010119-t1x9gknd 603 18 by by IN cord-010119-t1x9gknd 603 19 incubation incubation NN cord-010119-t1x9gknd 603 20 ( ( -LRB- cord-010119-t1x9gknd 603 21 30 30 CD cord-010119-t1x9gknd 603 22 minutes minute NNS cord-010119-t1x9gknd 603 23 or or CC cord-010119-t1x9gknd 603 24 more more JJR cord-010119-t1x9gknd 603 25 ) ) -RRB- cord-010119-t1x9gknd 603 26 results result VBZ cord-010119-t1x9gknd 603 27 in in IN cord-010119-t1x9gknd 603 28 widespread widespread JJ cord-010119-t1x9gknd 603 29 cell cell NN cord-010119-t1x9gknd 603 30 damage damage NN cord-010119-t1x9gknd 603 31 and and CC cord-010119-t1x9gknd 603 32 should should MD cord-010119-t1x9gknd 603 33 be be VB cord-010119-t1x9gknd 603 34 avoided avoid VBN cord-010119-t1x9gknd 603 35 . . . cord-010119-t1x9gknd 604 1 Safety Safety NNP cord-010119-t1x9gknd 604 2 Evaluation Evaluation NNP cord-010119-t1x9gknd 604 3 of of IN cord-010119-t1x9gknd 604 4 Lyophilized Lyophilized NNP cord-010119-t1x9gknd 604 5 Canine Canine NNP cord-010119-t1x9gknd 604 6 Platelets Platelets NNPS cord-010119-t1x9gknd 604 7 in in IN cord-010119-t1x9gknd 604 8 a a DT cord-010119-t1x9gknd 604 9 Model Model NNP cord-010119-t1x9gknd 604 10 of of IN cord-010119-t1x9gknd 604 11 Coronary Coronary NNP cord-010119-t1x9gknd 604 12 Artery Artery NNP cord-010119-t1x9gknd 604 13 Bypass Bypass NNP cord-010119-t1x9gknd 604 14 Graft Graft NNP cord-010119-t1x9gknd 604 15 ( ( -LRB- cord-010119-t1x9gknd 604 16 CABG CABG NNP cord-010119-t1x9gknd 604 17 ) ) -RRB- cord-010119-t1x9gknd 605 1 Todd Todd NNP cord-010119-t1x9gknd 605 2 M. M. NNP cord-010119-t1x9gknd 605 3 Getz Getz NNP cord-010119-t1x9gknd 605 4 * * NFP cord-010119-t1x9gknd 605 5 1 1 CD cord-010119-t1x9gknd 605 6 , , , cord-010119-t1x9gknd 605 7 Arthur Arthur NNP cord-010119-t1x9gknd 605 8 P. P. NNP cord-010119-t1x9gknd 605 9 Bode Bode NNP cord-010119-t1x9gknd 605 10 1 1 CD cord-010119-t1x9gknd 605 11 , , , cord-010119-t1x9gknd 605 12 Anne Anne NNP cord-010119-t1x9gknd 605 13 S S NNP cord-010119-t1x9gknd 605 14 Hale Hale NNP cord-010119-t1x9gknd 605 15 2 2 CD cord-010119-t1x9gknd 605 16 , , , cord-010119-t1x9gknd 605 17 Michael Michael NNP cord-010119-t1x9gknd 605 18 Stanton Stanton NNP cord-010119-t1x9gknd 605 19 3 3 CD cord-010119-t1x9gknd 605 20 , , , cord-010119-t1x9gknd 605 21 Mark Mark NNP cord-010119-t1x9gknd 605 22 Johnson Johnson NNP cord-010119-t1x9gknd 605 23 4 4 CD cord-010119-t1x9gknd 605 24 and and CC cord-010119-t1x9gknd 605 25 G. G. NNP cord-010119-t1x9gknd 605 26 Michael Michael NNP cord-010119-t1x9gknd 605 27 Fitzpatrick Fitzpatrick NNP cord-010119-t1x9gknd 605 28 3 3 CD cord-010119-t1x9gknd 605 29 . . . cord-010119-t1x9gknd 606 1 1 1 CD cord-010119-t1x9gknd 606 2 CellPhire CellPhire NNP cord-010119-t1x9gknd 606 3 , , , cord-010119-t1x9gknd 606 4 2 2 CD cord-010119-t1x9gknd 606 5 BodeVet BodeVet NNP cord-010119-t1x9gknd 606 6 , , , cord-010119-t1x9gknd 606 7 Inc Inc NNP cord-010119-t1x9gknd 606 8 , , , cord-010119-t1x9gknd 606 9 3 3 CD cord-010119-t1x9gknd 606 10 Cellphire Cellphire NNP cord-010119-t1x9gknd 606 11 , , , cord-010119-t1x9gknd 606 12 4 4 CD cord-010119-t1x9gknd 606 13 _SP cord-010119-t1x9gknd 606 14 Background Background NNP cord-010119-t1x9gknd 606 15 / / SYM cord-010119-t1x9gknd 606 16 Case Case NNP cord-010119-t1x9gknd 606 17 Studies Studies NNPS cord-010119-t1x9gknd 606 18 : : : cord-010119-t1x9gknd 606 19 Cellphire Cellphire NNP cord-010119-t1x9gknd 606 20 has have VBZ cord-010119-t1x9gknd 606 21 completed complete VBN cord-010119-t1x9gknd 606 22 a a DT cord-010119-t1x9gknd 606 23 micro micro JJ cord-010119-t1x9gknd 606 24 dose dose JJ cord-010119-t1x9gknd 606 25 clinical clinical JJ cord-010119-t1x9gknd 606 26 safety safety NN cord-010119-t1x9gknd 606 27 trial trial NN cord-010119-t1x9gknd 606 28 using use VBG cord-010119-t1x9gknd 606 29 lyophilized lyophilize VBN cord-010119-t1x9gknd 606 30 human human JJ cord-010119-t1x9gknd 606 31 platelets platelet NNS cord-010119-t1x9gknd 606 32 . . . cord-010119-t1x9gknd 607 1 Cellphire Cellphire NNP cord-010119-t1x9gknd 607 2 also also RB cord-010119-t1x9gknd 607 3 evaluated evaluate VBD cord-010119-t1x9gknd 607 4 the the DT cord-010119-t1x9gknd 607 5 safety safety NN cord-010119-t1x9gknd 607 6 of of IN cord-010119-t1x9gknd 607 7 Lyophilized Lyophilized NNP cord-010119-t1x9gknd 607 8 Canine Canine NNP cord-010119-t1x9gknd 607 9 Platelets Platelets NNPS cord-010119-t1x9gknd 607 10 ( ( -LRB- cord-010119-t1x9gknd 607 11 LCP LCP NNP cord-010119-t1x9gknd 607 12 ) ) -RRB- cord-010119-t1x9gknd 607 13 in in IN cord-010119-t1x9gknd 607 14 comparison comparison NN cord-010119-t1x9gknd 607 15 to to IN cord-010119-t1x9gknd 607 16 Liquid liquid NN cord-010119-t1x9gknd 607 17 Stored store VBN cord-010119-t1x9gknd 607 18 Canine canine JJ cord-010119-t1x9gknd 607 19 Platelets Platelets NNPS cord-010119-t1x9gknd 607 20 , , , cord-010119-t1x9gknd 607 21 following follow VBG cord-010119-t1x9gknd 607 22 intravenous intravenous JJ cord-010119-t1x9gknd 607 23 administration administration NN cord-010119-t1x9gknd 607 24 in in IN cord-010119-t1x9gknd 607 25 a a DT cord-010119-t1x9gknd 607 26 model model NN cord-010119-t1x9gknd 607 27 of of IN cord-010119-t1x9gknd 607 28 on on IN cord-010119-t1x9gknd 607 29 - - HYPH cord-010119-t1x9gknd 607 30 pump pump NN cord-010119-t1x9gknd 607 31 coronary coronary JJ cord-010119-t1x9gknd 607 32 artery artery NN cord-010119-t1x9gknd 607 33 bypass bypass NN cord-010119-t1x9gknd 607 34 graft graft NN cord-010119-t1x9gknd 607 35 ( ( -LRB- cord-010119-t1x9gknd 607 36 CABG CABG NNP cord-010119-t1x9gknd 607 37 ) ) -RRB- cord-010119-t1x9gknd 607 38 in in IN cord-010119-t1x9gknd 607 39 the the DT cord-010119-t1x9gknd 607 40 canine canine NN cord-010119-t1x9gknd 607 41 . . . cord-010119-t1x9gknd 608 1 This this DT cord-010119-t1x9gknd 608 2 safety safety NN cord-010119-t1x9gknd 608 3 study study NN cord-010119-t1x9gknd 608 4 was be VBD cord-010119-t1x9gknd 608 5 in in IN cord-010119-t1x9gknd 608 6 support support NN cord-010119-t1x9gknd 608 7 of of IN cord-010119-t1x9gknd 608 8 a a DT cord-010119-t1x9gknd 608 9 future future JJ cord-010119-t1x9gknd 608 10 Phase Phase NNP cord-010119-t1x9gknd 608 11 II II NNP cord-010119-t1x9gknd 608 12 human human JJ cord-010119-t1x9gknd 608 13 clinical clinical JJ cord-010119-t1x9gknd 608 14 trial trial NN cord-010119-t1x9gknd 608 15 in in IN cord-010119-t1x9gknd 608 16 cardiac cardiac JJ cord-010119-t1x9gknd 608 17 patients patient NNS cord-010119-t1x9gknd 608 18 . . . cord-010119-t1x9gknd 609 1 Study Study NNP cord-010119-t1x9gknd 609 2 Design Design NNP cord-010119-t1x9gknd 609 3 / / SYM cord-010119-t1x9gknd 609 4 Method method NN cord-010119-t1x9gknd 609 5 : : : cord-010119-t1x9gknd 610 1 Three three CD cord-010119-t1x9gknd 610 2 groups group NNS cord-010119-t1x9gknd 610 3 of of IN cord-010119-t1x9gknd 610 4 eight eight CD cord-010119-t1x9gknd 610 5 mixed mixed JJ cord-010119-t1x9gknd 610 6 breed breed NN cord-010119-t1x9gknd 610 7 hounds hound NNS cord-010119-t1x9gknd 610 8 underwent undergo VBD cord-010119-t1x9gknd 610 9 CABG CABG NNP cord-010119-t1x9gknd 610 10 to to TO cord-010119-t1x9gknd 610 11 create create VB cord-010119-t1x9gknd 610 12 an an DT cord-010119-t1x9gknd 610 13 anastomosis anastomosis NN cord-010119-t1x9gknd 610 14 and and CC cord-010119-t1x9gknd 610 15 were be VBD cord-010119-t1x9gknd 610 16 administered administer VBN cord-010119-t1x9gknd 610 17 LCPs lcp NNS cord-010119-t1x9gknd 610 18 equal equal JJ cord-010119-t1x9gknd 610 19 to to IN cord-010119-t1x9gknd 610 20 33 33 CD cord-010119-t1x9gknd 610 21 , , , cord-010119-t1x9gknd 610 22 10 10 CD cord-010119-t1x9gknd 610 23 , , , cord-010119-t1x9gknd 610 24 and and CC cord-010119-t1x9gknd 610 25 3.3 3.3 CD cord-010119-t1x9gknd 610 26 % % NN cord-010119-t1x9gknd 610 27 of of IN cord-010119-t1x9gknd 610 28 the the DT cord-010119-t1x9gknd 610 29 Total total JJ cord-010119-t1x9gknd 610 30 Circulating Circulating NNP cord-010119-t1x9gknd 610 31 Platelet platelet NN cord-010119-t1x9gknd 610 32 Count Count NNP cord-010119-t1x9gknd 610 33 ( ( -LRB- cord-010119-t1x9gknd 610 34 TCPC TCPC NNP cord-010119-t1x9gknd 610 35 ) ) -RRB- cord-010119-t1x9gknd 610 36 . . . cord-010119-t1x9gknd 611 1 One one CD cord-010119-t1x9gknd 611 2 group group NN cord-010119-t1x9gknd 611 3 of of IN cord-010119-t1x9gknd 611 4 four four CD cord-010119-t1x9gknd 611 5 animals animal NNS cord-010119-t1x9gknd 611 6 served serve VBD cord-010119-t1x9gknd 611 7 as as IN cord-010119-t1x9gknd 611 8 the the DT cord-010119-t1x9gknd 611 9 vehicle vehicle NN cord-010119-t1x9gknd 611 10 group group NN cord-010119-t1x9gknd 611 11 which which WDT cord-010119-t1x9gknd 611 12 received receive VBD cord-010119-t1x9gknd 611 13 lyophilization lyophilization NN cord-010119-t1x9gknd 611 14 platelet platelet NN cord-010119-t1x9gknd 611 15 - - HYPH cord-010119-t1x9gknd 611 16 formulation formulation NN cord-010119-t1x9gknd 611 17 buffer buffer NN cord-010119-t1x9gknd 611 18 , , , cord-010119-t1x9gknd 611 19 and and CC cord-010119-t1x9gknd 611 20 another another DT cord-010119-t1x9gknd 611 21 group group NN cord-010119-t1x9gknd 611 22 of of IN cord-010119-t1x9gknd 611 23 four four CD cord-010119-t1x9gknd 611 24 animals animal NNS cord-010119-t1x9gknd 611 25 received receive VBD cord-010119-t1x9gknd 611 26 control control NN cord-010119-t1x9gknd 611 27 ( ( -LRB- cord-010119-t1x9gknd 611 28 2-day 2-day JJ cord-010119-t1x9gknd 611 29 old old JJ cord-010119-t1x9gknd 611 30 liquid liquid NN cord-010119-t1x9gknd 611 31 - - HYPH cord-010119-t1x9gknd 611 32 stored store VBN cord-010119-t1x9gknd 611 33 platelets platelet NNS cord-010119-t1x9gknd 611 34 ) ) -RRB- cord-010119-t1x9gknd 611 35 . . . cord-010119-t1x9gknd 612 1 Safety safety NN cord-010119-t1x9gknd 612 2 was be VBD cord-010119-t1x9gknd 612 3 assessed assess VBN cord-010119-t1x9gknd 612 4 through through IN cord-010119-t1x9gknd 612 5 the the DT cord-010119-t1x9gknd 612 6 collection collection NN cord-010119-t1x9gknd 612 7 of of IN cord-010119-t1x9gknd 612 8 blood blood NN cord-010119-t1x9gknd 612 9 loss loss NN cord-010119-t1x9gknd 612 10 data datum NNS cord-010119-t1x9gknd 612 11 , , , cord-010119-t1x9gknd 612 12 evaluation evaluation NN cord-010119-t1x9gknd 612 13 of of IN cord-010119-t1x9gknd 612 14 blood blood NN cord-010119-t1x9gknd 612 15 flow flow NN cord-010119-t1x9gknd 612 16 through through IN cord-010119-t1x9gknd 612 17 the the DT cord-010119-t1x9gknd 612 18 bypass bypass NN cord-010119-t1x9gknd 612 19 graft graft NN cord-010119-t1x9gknd 612 20 , , , cord-010119-t1x9gknd 612 21 evaluation evaluation NN cord-010119-t1x9gknd 612 22 of of IN cord-010119-t1x9gknd 612 23 the the DT cord-010119-t1x9gknd 612 24 development development NN cord-010119-t1x9gknd 612 25 of of IN cord-010119-t1x9gknd 612 26 acute acute JJ cord-010119-t1x9gknd 612 27 thrombosis thrombosis NN cord-010119-t1x9gknd 612 28 , , , cord-010119-t1x9gknd 612 29 and and CC cord-010119-t1x9gknd 612 30 maintenance maintenance NN cord-010119-t1x9gknd 612 31 of of IN cord-010119-t1x9gknd 612 32 patency patency NN cord-010119-t1x9gknd 612 33 through through IN cord-010119-t1x9gknd 612 34 the the DT cord-010119-t1x9gknd 612 35 graft graft NN cord-010119-t1x9gknd 612 36 over over IN cord-010119-t1x9gknd 612 37 the the DT cord-010119-t1x9gknd 612 38 4 4 CD cord-010119-t1x9gknd 612 39 hr hr NN cord-010119-t1x9gknd 612 40 evaluation evaluation NN cord-010119-t1x9gknd 612 41 period period NN cord-010119-t1x9gknd 612 42 . . . cord-010119-t1x9gknd 613 1 Full full JJ cord-010119-t1x9gknd 613 2 necropsies necropsy NNS cord-010119-t1x9gknd 613 3 with with IN cord-010119-t1x9gknd 613 4 complete complete JJ cord-010119-t1x9gknd 613 5 tissue tissue NN cord-010119-t1x9gknd 613 6 analysis analysis NN cord-010119-t1x9gknd 613 7 were be VBD cord-010119-t1x9gknd 613 8 also also RB cord-010119-t1x9gknd 613 9 performed perform VBN cord-010119-t1x9gknd 613 10 . . . cord-010119-t1x9gknd 614 1 Efficacy efficacy NN cord-010119-t1x9gknd 614 2 signals signal NNS cord-010119-t1x9gknd 614 3 were be VBD cord-010119-t1x9gknd 614 4 evaluated evaluate VBN cord-010119-t1x9gknd 614 5 through through IN cord-010119-t1x9gknd 614 6 the the DT cord-010119-t1x9gknd 614 7 collection collection NN cord-010119-t1x9gknd 614 8 of of IN cord-010119-t1x9gknd 614 9 blood blood NN cord-010119-t1x9gknd 614 10 loss loss NN cord-010119-t1x9gknd 614 11 data datum NNS cord-010119-t1x9gknd 614 12 and and CC cord-010119-t1x9gknd 614 13 coagulation coagulation NN cord-010119-t1x9gknd 614 14 endpoints endpoint NNS cord-010119-t1x9gknd 614 15 ( ( -LRB- cord-010119-t1x9gknd 614 16 PT PT NNP cord-010119-t1x9gknd 614 17 , , , cord-010119-t1x9gknd 614 18 APTT APTT NNP cord-010119-t1x9gknd 614 19 , , , cord-010119-t1x9gknd 614 20 Fibrinogen Fibrinogen NNP cord-010119-t1x9gknd 614 21 , , , cord-010119-t1x9gknd 614 22 and and CC cord-010119-t1x9gknd 614 23 TEG TEG NNP cord-010119-t1x9gknd 614 24 ) ) -RRB- cord-010119-t1x9gknd 614 25 . . . cord-010119-t1x9gknd 615 1 The the DT cord-010119-t1x9gknd 615 2 results result NNS cord-010119-t1x9gknd 615 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 615 4 that that IN cord-010119-t1x9gknd 615 5 administration administration NN cord-010119-t1x9gknd 615 6 of of IN cord-010119-t1x9gknd 615 7 the the DT cord-010119-t1x9gknd 615 8 test test NN cord-010119-t1x9gknd 615 9 article article NN cord-010119-t1x9gknd 615 10 at at IN cord-010119-t1x9gknd 615 11 doses dose NNS cord-010119-t1x9gknd 615 12 up up IN cord-010119-t1x9gknd 615 13 to to TO cord-010119-t1x9gknd 615 14 33 33 CD cord-010119-t1x9gknd 615 15 % % NN cord-010119-t1x9gknd 615 16 of of IN cord-010119-t1x9gknd 615 17 the the DT cord-010119-t1x9gknd 615 18 TCPC TCPC NNP cord-010119-t1x9gknd 615 19 was be VBD cord-010119-t1x9gknd 615 20 not not RB cord-010119-t1x9gknd 615 21 associated associate VBN cord-010119-t1x9gknd 615 22 with with IN cord-010119-t1x9gknd 615 23 any any DT cord-010119-t1x9gknd 615 24 unexpected unexpected JJ cord-010119-t1x9gknd 615 25 mortality mortality NN cord-010119-t1x9gknd 615 26 , , , cord-010119-t1x9gknd 615 27 adverse adverse JJ cord-010119-t1x9gknd 615 28 changes change NNS cord-010119-t1x9gknd 615 29 in in IN cord-010119-t1x9gknd 615 30 hematology hematology NN cord-010119-t1x9gknd 615 31 or or CC cord-010119-t1x9gknd 615 32 coagulation coagulation NN cord-010119-t1x9gknd 615 33 parameters parameter NNS cord-010119-t1x9gknd 615 34 , , , cord-010119-t1x9gknd 615 35 development development NN cord-010119-t1x9gknd 615 36 of of IN cord-010119-t1x9gknd 615 37 thrombosis thrombosis NN cord-010119-t1x9gknd 615 38 at at IN cord-010119-t1x9gknd 615 39 the the DT cord-010119-t1x9gknd 615 40 anastomosis anastomosis NN cord-010119-t1x9gknd 615 41 sites site NNS cord-010119-t1x9gknd 615 42 , , , cord-010119-t1x9gknd 615 43 or or CC cord-010119-t1x9gknd 615 44 evidence evidence NN cord-010119-t1x9gknd 615 45 of of IN cord-010119-t1x9gknd 615 46 adverse adverse JJ cord-010119-t1x9gknd 615 47 thrombosis thrombosis NN cord-010119-t1x9gknd 615 48 formation formation NN cord-010119-t1x9gknd 615 49 either either CC cord-010119-t1x9gknd 615 50 clinically clinically RB cord-010119-t1x9gknd 615 51 or or CC cord-010119-t1x9gknd 615 52 microscopically microscopically RB cord-010119-t1x9gknd 615 53 regardless regardless RB cord-010119-t1x9gknd 615 54 of of IN cord-010119-t1x9gknd 615 55 group group NN cord-010119-t1x9gknd 615 56 . . . cord-010119-t1x9gknd 616 1 The the DT cord-010119-t1x9gknd 616 2 mortality mortality NN cord-010119-t1x9gknd 616 3 noted note VBD cord-010119-t1x9gknd 616 4 on on IN cord-010119-t1x9gknd 616 5 study study NN cord-010119-t1x9gknd 616 6 was be VBD cord-010119-t1x9gknd 616 7 considered consider VBN cord-010119-t1x9gknd 616 8 to to TO cord-010119-t1x9gknd 616 9 be be VB cord-010119-t1x9gknd 616 10 related relate VBN cord-010119-t1x9gknd 616 11 to to IN cord-010119-t1x9gknd 616 12 the the DT cord-010119-t1x9gknd 616 13 surgical surgical JJ cord-010119-t1x9gknd 616 14 model model NN cord-010119-t1x9gknd 616 15 and and CC cord-010119-t1x9gknd 616 16 not not RB cord-010119-t1x9gknd 616 17 a a DT cord-010119-t1x9gknd 616 18 result result NN cord-010119-t1x9gknd 616 19 of of IN cord-010119-t1x9gknd 616 20 test test NN cord-010119-t1x9gknd 616 21 article article NN cord-010119-t1x9gknd 616 22 administration administration NN cord-010119-t1x9gknd 616 23 . . . cord-010119-t1x9gknd 617 1 The the DT cord-010119-t1x9gknd 617 2 results result NNS cord-010119-t1x9gknd 617 3 also also RB cord-010119-t1x9gknd 617 4 demonstrated demonstrate VBD cord-010119-t1x9gknd 617 5 that that IN cord-010119-t1x9gknd 617 6 administration administration NN cord-010119-t1x9gknd 617 7 of of IN cord-010119-t1x9gknd 617 8 doses dose NNS cord-010119-t1x9gknd 617 9 of of IN cord-010119-t1x9gknd 617 10 10 10 CD cord-010119-t1x9gknd 617 11 % % NN cord-010119-t1x9gknd 617 12 and and CC cord-010119-t1x9gknd 617 13 33 33 CD cord-010119-t1x9gknd 617 14 % % NN cord-010119-t1x9gknd 617 15 of of IN cord-010119-t1x9gknd 617 16 the the DT cord-010119-t1x9gknd 617 17 TCPC TCPC NNP cord-010119-t1x9gknd 617 18 produced produce VBD cord-010119-t1x9gknd 617 19 a a DT cord-010119-t1x9gknd 617 20 significant significant JJ cord-010119-t1x9gknd 617 21 decrease decrease NN cord-010119-t1x9gknd 617 22 in in IN cord-010119-t1x9gknd 617 23 blood blood NN cord-010119-t1x9gknd 617 24 loss loss NN cord-010119-t1x9gknd 617 25 . . . cord-010119-t1x9gknd 618 1 The the DT cord-010119-t1x9gknd 618 2 LCPs lcp NNS cord-010119-t1x9gknd 618 3 at at IN cord-010119-t1x9gknd 618 4 10 10 CD cord-010119-t1x9gknd 618 5 % % NN cord-010119-t1x9gknd 618 6 and and CC cord-010119-t1x9gknd 618 7 33 33 CD cord-010119-t1x9gknd 618 8 % % NN cord-010119-t1x9gknd 618 9 TCPC TCPC NNP cord-010119-t1x9gknd 618 10 were be VBD cord-010119-t1x9gknd 618 11 as as RB cord-010119-t1x9gknd 618 12 effective effective JJ cord-010119-t1x9gknd 618 13 in in IN cord-010119-t1x9gknd 618 14 mitigating mitigate VBG cord-010119-t1x9gknd 618 15 blood blood NN cord-010119-t1x9gknd 618 16 loss loss NN cord-010119-t1x9gknd 618 17 as as IN cord-010119-t1x9gknd 618 18 2-day 2-day JJ cord-010119-t1x9gknd 618 19 old old JJ cord-010119-t1x9gknd 618 20 liquid liquid NN cord-010119-t1x9gknd 618 21 - - HYPH cord-010119-t1x9gknd 618 22 stored store VBN cord-010119-t1x9gknd 618 23 platelets platelet NNS cord-010119-t1x9gknd 618 24 and and CC cord-010119-t1x9gknd 618 25 trended trend VBD cord-010119-t1x9gknd 618 26 towards towards IN cord-010119-t1x9gknd 618 27 being be VBG cord-010119-t1x9gknd 618 28 more more RBR cord-010119-t1x9gknd 618 29 effective effective JJ cord-010119-t1x9gknd 618 30 . . . cord-010119-t1x9gknd 619 1 No no DT cord-010119-t1x9gknd 619 2 appreciable appreciable JJ cord-010119-t1x9gknd 619 3 differences difference NNS cord-010119-t1x9gknd 619 4 in in IN cord-010119-t1x9gknd 619 5 coagulation coagulation NN cord-010119-t1x9gknd 619 6 parameters parameter NNS cord-010119-t1x9gknd 619 7 were be VBD cord-010119-t1x9gknd 619 8 observed observe VBN cord-010119-t1x9gknd 619 9 between between IN cord-010119-t1x9gknd 619 10 groups group NNS cord-010119-t1x9gknd 619 11 . . . cord-010119-t1x9gknd 620 1 Conclusion conclusion NN cord-010119-t1x9gknd 620 2 : : : cord-010119-t1x9gknd 621 1 The the DT cord-010119-t1x9gknd 621 2 results result NNS cord-010119-t1x9gknd 621 3 of of IN cord-010119-t1x9gknd 621 4 the the DT cord-010119-t1x9gknd 621 5 study study NN cord-010119-t1x9gknd 621 6 demonstrate demonstrate VBP cord-010119-t1x9gknd 621 7 that that IN cord-010119-t1x9gknd 621 8 administration administration NN cord-010119-t1x9gknd 621 9 of of IN cord-010119-t1x9gknd 621 10 LCP LCP NNP cord-010119-t1x9gknd 621 11 up up IN cord-010119-t1x9gknd 621 12 to to TO cord-010119-t1x9gknd 621 13 33 33 CD cord-010119-t1x9gknd 621 14 % % NN cord-010119-t1x9gknd 621 15 of of IN cord-010119-t1x9gknd 621 16 the the DT cord-010119-t1x9gknd 621 17 TCPC TCPC NNP cord-010119-t1x9gknd 621 18 was be VBD cord-010119-t1x9gknd 621 19 safe safe JJ cord-010119-t1x9gknd 621 20 in in IN cord-010119-t1x9gknd 621 21 a a DT cord-010119-t1x9gknd 621 22 canine canine JJ cord-010119-t1x9gknd 621 23 CABG CABG NNP cord-010119-t1x9gknd 621 24 model model NN cord-010119-t1x9gknd 621 25 . . . cord-010119-t1x9gknd 622 1 The the DT cord-010119-t1x9gknd 622 2 data datum NNS cord-010119-t1x9gknd 622 3 also also RB cord-010119-t1x9gknd 622 4 demonstrate demonstrate VBP cord-010119-t1x9gknd 622 5 that that IN cord-010119-t1x9gknd 622 6 administration administration NN cord-010119-t1x9gknd 622 7 of of IN cord-010119-t1x9gknd 622 8 LCP LCP NNP cord-010119-t1x9gknd 622 9 at at IN cord-010119-t1x9gknd 622 10 doses dose NNS cord-010119-t1x9gknd 622 11 of of IN cord-010119-t1x9gknd 622 12 10 10 CD cord-010119-t1x9gknd 622 13 % % NN cord-010119-t1x9gknd 622 14 and and CC cord-010119-t1x9gknd 622 15 33 33 CD cord-010119-t1x9gknd 622 16 % % NN cord-010119-t1x9gknd 622 17 of of IN cord-010119-t1x9gknd 622 18 the the DT cord-010119-t1x9gknd 622 19 TCPC TCPC NNP cord-010119-t1x9gknd 622 20 reduced reduce VBN cord-010119-t1x9gknd 622 21 blood blood NN cord-010119-t1x9gknd 622 22 loss loss NN cord-010119-t1x9gknd 622 23 . . . cord-010119-t1x9gknd 623 1 These these DT cord-010119-t1x9gknd 623 2 results result NNS cord-010119-t1x9gknd 623 3 suggest suggest VBP cord-010119-t1x9gknd 623 4 a a DT cord-010119-t1x9gknd 623 5 starting starting NN cord-010119-t1x9gknd 623 6 dose dose NN cord-010119-t1x9gknd 623 7 above above IN cord-010119-t1x9gknd 623 8 3.3 3.3 CD cord-010119-t1x9gknd 623 9 % % NN cord-010119-t1x9gknd 623 10 TCPC TCPC NNP cord-010119-t1x9gknd 623 11 may may MD cord-010119-t1x9gknd 623 12 be be VB cord-010119-t1x9gknd 623 13 required require VBN cord-010119-t1x9gknd 623 14 to to TO cord-010119-t1x9gknd 623 15 achieve achieve VB cord-010119-t1x9gknd 623 16 an an DT cord-010119-t1x9gknd 623 17 effective effective JJ cord-010119-t1x9gknd 623 18 dose dose NN cord-010119-t1x9gknd 623 19 in in IN cord-010119-t1x9gknd 623 20 future future JJ cord-010119-t1x9gknd 623 21 human human NN cord-010119-t1x9gknd 623 22 Phase Phase NNP cord-010119-t1x9gknd 623 23 II ii CD cord-010119-t1x9gknd 623 24 trials trial NNS cord-010119-t1x9gknd 623 25 in in IN cord-010119-t1x9gknd 623 26 cardiac cardiac JJ cord-010119-t1x9gknd 623 27 patients patient NNS cord-010119-t1x9gknd 623 28 . . . cord-010119-t1x9gknd 624 1 Although although IN cord-010119-t1x9gknd 624 2 the the DT cord-010119-t1x9gknd 624 3 study study NN cord-010119-t1x9gknd 624 4 was be VBD cord-010119-t1x9gknd 624 5 not not RB cord-010119-t1x9gknd 624 6 powered power VBN cord-010119-t1x9gknd 624 7 for for IN cord-010119-t1x9gknd 624 8 efficacy efficacy NN cord-010119-t1x9gknd 624 9 , , , cord-010119-t1x9gknd 624 10 these these DT cord-010119-t1x9gknd 624 11 data datum NNS cord-010119-t1x9gknd 624 12 indicate indicate VBP cord-010119-t1x9gknd 624 13 a a DT cord-010119-t1x9gknd 624 14 level level NN cord-010119-t1x9gknd 624 15 of of IN cord-010119-t1x9gknd 624 16 safety safety NN cord-010119-t1x9gknd 624 17 , , , cord-010119-t1x9gknd 624 18 as as IN cord-010119-t1x9gknd 624 19 10 10 CD cord-010119-t1x9gknd 624 20 % % NN cord-010119-t1x9gknd 624 21 TCPC TCPC NNP cord-010119-t1x9gknd 624 22 had have VBD cord-010119-t1x9gknd 624 23 similar similar JJ cord-010119-t1x9gknd 624 24 efficacy efficacy NN cord-010119-t1x9gknd 624 25 signals signal NNS cord-010119-t1x9gknd 624 26 as as IN cord-010119-t1x9gknd 624 27 33 33 CD cord-010119-t1x9gknd 624 28 % % NN cord-010119-t1x9gknd 624 29 TCPC TCPC NNP cord-010119-t1x9gknd 624 30 with with IN cord-010119-t1x9gknd 624 31 no no DT cord-010119-t1x9gknd 624 32 observable observable JJ cord-010119-t1x9gknd 624 33 severe severe JJ cord-010119-t1x9gknd 624 34 adverse adverse JJ cord-010119-t1x9gknd 624 35 events event NNS cord-010119-t1x9gknd 624 36 . . . cord-010119-t1x9gknd 625 1 The the DT cord-010119-t1x9gknd 625 2 starting start VBG cord-010119-t1x9gknd 625 3 effective effective JJ cord-010119-t1x9gknd 625 4 dose dose NN cord-010119-t1x9gknd 625 5 may may MD cord-010119-t1x9gknd 625 6 vary vary VB cord-010119-t1x9gknd 625 7 depending depend VBG cord-010119-t1x9gknd 625 8 on on IN cord-010119-t1x9gknd 625 9 the the DT cord-010119-t1x9gknd 625 10 clinical clinical JJ cord-010119-t1x9gknd 625 11 indication indication NN cord-010119-t1x9gknd 625 12 . . . cord-010119-t1x9gknd 626 1 Future future JJ cord-010119-t1x9gknd 626 2 studies study NNS cord-010119-t1x9gknd 626 3 will will MD cord-010119-t1x9gknd 626 4 be be VB cord-010119-t1x9gknd 626 5 required require VBN cord-010119-t1x9gknd 626 6 . . . cord-010119-t1x9gknd 627 1 This this DT cord-010119-t1x9gknd 627 2 study study NN cord-010119-t1x9gknd 627 3 was be VBD cord-010119-t1x9gknd 627 4 funded fund VBN cord-010119-t1x9gknd 627 5 under under IN cord-010119-t1x9gknd 627 6 BARDA BARDA NNP cord-010119-t1x9gknd 627 7 contract contract NN cord-010119-t1x9gknd 627 8 HHSO100201300021C. HHSO100201300021C. NNP cord-010119-t1x9gknd 628 1 The the DT cord-010119-t1x9gknd 628 2 Study Study NNP cord-010119-t1x9gknd 628 3 on on IN cord-010119-t1x9gknd 628 4 PCR PCR NNP cord-010119-t1x9gknd 628 5 - - HYPH cord-010119-t1x9gknd 628 6 SSP SSP NNP cord-010119-t1x9gknd 628 7 Technique Technique NNP cord-010119-t1x9gknd 628 8 for for IN cord-010119-t1x9gknd 628 9 the the DT cord-010119-t1x9gknd 628 10 Genotyping Genotyping NNP cord-010119-t1x9gknd 628 11 of of IN cord-010119-t1x9gknd 628 12 CD36 CD36 NNP cord-010119-t1x9gknd 628 13 329 329 CD cord-010119-t1x9gknd 628 14 - - SYM cord-010119-t1x9gknd 628 15 330del 330del CD cord-010119-t1x9gknd 628 16 . . . cord-010119-t1x9gknd 629 1 AC AC NNP cord-010119-t1x9gknd 629 2 Mutation Mutation NNP cord-010119-t1x9gknd 629 3 and and CC cord-010119-t1x9gknd 629 4 the the DT cord-010119-t1x9gknd 629 5 Genetic Genetic NNP cord-010119-t1x9gknd 629 6 Polymorphism Polymorphism NNP cord-010119-t1x9gknd 629 7 of of IN cord-010119-t1x9gknd 629 8 CD36 CD36 NNP cord-010119-t1x9gknd 630 1 329 329 CD cord-010119-t1x9gknd 630 2 - - SYM cord-010119-t1x9gknd 630 3 330del 330del CD cord-010119-t1x9gknd 630 4 . . . cord-010119-t1x9gknd 631 1 AC AC NNP cord-010119-t1x9gknd 631 2 in in IN cord-010119-t1x9gknd 631 3 Chinese Chinese NNP cord-010119-t1x9gknd 631 4 Population Population NNP cord-010119-t1x9gknd 631 5 Lilan Lilan NNP cord-010119-t1x9gknd 631 6 LI LI NNP cord-010119-t1x9gknd 632 1 * * NFP cord-010119-t1x9gknd 632 2 and and CC cord-010119-t1x9gknd 632 3 Guoguang Guoguang NNP cord-010119-t1x9gknd 632 4 WU WU NNP cord-010119-t1x9gknd 632 5 . . . cord-010119-t1x9gknd 633 1 Nan Nan NNP cord-010119-t1x9gknd 633 2 - - HYPH cord-010119-t1x9gknd 633 3 Ning Ning NNP cord-010119-t1x9gknd 633 4 Institute Institute NNP cord-010119-t1x9gknd 633 5 of of IN cord-010119-t1x9gknd 633 6 Transfusion Transfusion NNP cord-010119-t1x9gknd 633 7 Medicine Medicine NNP cord-010119-t1x9gknd 633 8 Background Background NNP cord-010119-t1x9gknd 633 9 / / SYM cord-010119-t1x9gknd 633 10 Case Case NNP cord-010119-t1x9gknd 633 11 Studies Studies NNPS cord-010119-t1x9gknd 633 12 : : : cord-010119-t1x9gknd 633 13 CD36 CD36 NNP cord-010119-t1x9gknd 633 14 ( ( -LRB- cord-010119-t1x9gknd 633 15 Platelet platelet NN cord-010119-t1x9gknd 633 16 glycoprotein glycoprotein NN cord-010119-t1x9gknd 633 17 IV IV NNP cord-010119-t1x9gknd 633 18 , , , cord-010119-t1x9gknd 633 19 SCARB3 SCARB3 NNP cord-010119-t1x9gknd 633 20 ) ) -RRB- cord-010119-t1x9gknd 633 21 is be VBZ cord-010119-t1x9gknd 633 22 an an DT cord-010119-t1x9gknd 633 23 important important JJ cord-010119-t1x9gknd 633 24 and and CC cord-010119-t1x9gknd 633 25 characteristic characteristic JJ cord-010119-t1x9gknd 633 26 platelet platelet NN cord-010119-t1x9gknd 633 27 antigen antigen NN cord-010119-t1x9gknd 633 28 implicated implicate VBN cord-010119-t1x9gknd 633 29 in in IN cord-010119-t1x9gknd 633 30 immune immune NN cord-010119-t1x9gknd 633 31 - - HYPH cord-010119-t1x9gknd 633 32 mediated mediate VBN cord-010119-t1x9gknd 633 33 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 633 34 in in IN cord-010119-t1x9gknd 633 35 Chinese chinese JJ cord-010119-t1x9gknd 633 36 population population NN cord-010119-t1x9gknd 633 37 . . . cord-010119-t1x9gknd 634 1 Except except IN cord-010119-t1x9gknd 634 2 anti anti JJ cord-010119-t1x9gknd 634 3 - - NNP cord-010119-t1x9gknd 634 4 HLA HLA NNP cord-010119-t1x9gknd 634 5 , , , cord-010119-t1x9gknd 634 6 anti anti JJ cord-010119-t1x9gknd 634 7 - - NNP cord-010119-t1x9gknd 634 8 CD36 CD36 NNP cord-010119-t1x9gknd 634 9 is be VBZ cord-010119-t1x9gknd 634 10 the the DT cord-010119-t1x9gknd 634 11 most most RBS cord-010119-t1x9gknd 634 12 common common JJ cord-010119-t1x9gknd 634 13 antibody antibody NN cord-010119-t1x9gknd 634 14 of of IN cord-010119-t1x9gknd 634 15 clinically clinically RB cord-010119-t1x9gknd 634 16 relevant relevant JJ cord-010119-t1x9gknd 634 17 platelet platelet NN cord-010119-t1x9gknd 634 18 antibodies antibody NNS cord-010119-t1x9gknd 634 19 in in IN cord-010119-t1x9gknd 634 20 Chinese chinese JJ cord-010119-t1x9gknd 634 21 population population NN cord-010119-t1x9gknd 634 22 , , , cord-010119-t1x9gknd 634 23 which which WDT cord-010119-t1x9gknd 634 24 is be VBZ cord-010119-t1x9gknd 634 25 associated associate VBN cord-010119-t1x9gknd 634 26 with with IN cord-010119-t1x9gknd 634 27 the the DT cord-010119-t1x9gknd 634 28 high high JJ cord-010119-t1x9gknd 634 29 frequency frequency NN cord-010119-t1x9gknd 634 30 of of IN cord-010119-t1x9gknd 634 31 CD36 CD36 NNP cord-010119-t1x9gknd 634 32 deficiency deficiency NN cord-010119-t1x9gknd 634 33 in in IN cord-010119-t1x9gknd 634 34 China China NNP cord-010119-t1x9gknd 634 35 . . . cord-010119-t1x9gknd 635 1 CD36 CD36 NNP cord-010119-t1x9gknd 635 2 gene gene NN cord-010119-t1x9gknd 635 3 mutation mutation NN cord-010119-t1x9gknd 635 4 is be VBZ cord-010119-t1x9gknd 635 5 the the DT cord-010119-t1x9gknd 635 6 main main JJ cord-010119-t1x9gknd 635 7 reason reason NN cord-010119-t1x9gknd 635 8 that that WDT cord-010119-t1x9gknd 635 9 leads lead VBZ cord-010119-t1x9gknd 635 10 to to IN cord-010119-t1x9gknd 635 11 CD36 CD36 NNP cord-010119-t1x9gknd 635 12 deficiency deficiency NN cord-010119-t1x9gknd 635 13 . . . cord-010119-t1x9gknd 636 1 CD36 CD36 NNP cord-010119-t1x9gknd 636 2 329 329 CD cord-010119-t1x9gknd 636 3 - - SYM cord-010119-t1x9gknd 636 4 330del 330del CD cord-010119-t1x9gknd 636 5 . . . cord-010119-t1x9gknd 637 1 AC AC NNP cord-010119-t1x9gknd 637 2 ( ( -LRB- cord-010119-t1x9gknd 637 3 frameshift frameshift NN cord-010119-t1x9gknd 637 4 at at IN cord-010119-t1x9gknd 637 5 AA110 aa110 NN cord-010119-t1x9gknd 638 1 ) ) -RRB- cord-010119-t1x9gknd 638 2 mutation mutation NN cord-010119-t1x9gknd 638 3 is be VBZ cord-010119-t1x9gknd 638 4 one one CD cord-010119-t1x9gknd 638 5 of of IN cord-010119-t1x9gknd 638 6 the the DT cord-010119-t1x9gknd 638 7 CD36 CD36 NNP cord-010119-t1x9gknd 638 8 mutations mutation NNS cord-010119-t1x9gknd 638 9 that that WDT cord-010119-t1x9gknd 638 10 causes cause VBZ cord-010119-t1x9gknd 638 11 CD36 CD36 NNP cord-010119-t1x9gknd 638 12 deficiency deficiency NN cord-010119-t1x9gknd 638 13 . . . cord-010119-t1x9gknd 639 1 have have VBP cord-010119-t1x9gknd 639 2 had have VBN cord-010119-t1x9gknd 639 3 natural natural JJ cord-010119-t1x9gknd 639 4 mumps mump NNS cord-010119-t1x9gknd 639 5 , , , cord-010119-t1x9gknd 639 6 measles measle NNS cord-010119-t1x9gknd 639 7 and and CC cord-010119-t1x9gknd 639 8 rubella rubella NN cord-010119-t1x9gknd 639 9 infections infection NNS cord-010119-t1x9gknd 639 10 , , , cord-010119-t1x9gknd 639 11 resulting result VBG cord-010119-t1x9gknd 639 12 in in IN cord-010119-t1x9gknd 639 13 lower low JJR cord-010119-t1x9gknd 639 14 antibody antibody NN cord-010119-t1x9gknd 639 15 levels level NNS cord-010119-t1x9gknd 639 16 in in IN cord-010119-t1x9gknd 639 17 their -PRON- PRP$ cord-010119-t1x9gknd 639 18 blood blood NN cord-010119-t1x9gknd 639 19 . . . cord-010119-t1x9gknd 640 1 The the DT cord-010119-t1x9gknd 640 2 recommendations recommendation NNS cord-010119-t1x9gknd 640 3 may may MD cord-010119-t1x9gknd 640 4 thus thus RB cord-010119-t1x9gknd 640 5 be be VB cord-010119-t1x9gknd 640 6 unfounded unfounded JJ cord-010119-t1x9gknd 640 7 and and CC cord-010119-t1x9gknd 640 8 outdated outdated JJ cord-010119-t1x9gknd 640 9 , , , cord-010119-t1x9gknd 640 10 and and CC cord-010119-t1x9gknd 640 11 prevent prevent VB cord-010119-t1x9gknd 640 12 valuable valuable JJ cord-010119-t1x9gknd 640 13 vaccination vaccination NN cord-010119-t1x9gknd 640 14 opportunities opportunity NNS cord-010119-t1x9gknd 640 15 for for IN cord-010119-t1x9gknd 640 16 children child NNS cord-010119-t1x9gknd 640 17 with with IN cord-010119-t1x9gknd 640 18 frequent frequent JJ cord-010119-t1x9gknd 640 19 blood blood NN cord-010119-t1x9gknd 640 20 transfusions transfusion NNS cord-010119-t1x9gknd 640 21 . . . cord-010119-t1x9gknd 641 1 This this DT cord-010119-t1x9gknd 641 2 places place VBZ cord-010119-t1x9gknd 641 3 an an DT cord-010119-t1x9gknd 641 4 already already RB cord-010119-t1x9gknd 641 5 highly highly RB cord-010119-t1x9gknd 641 6 vulnerable vulnerable JJ cord-010119-t1x9gknd 641 7 pediatric pediatric JJ cord-010119-t1x9gknd 641 8 population population NN cord-010119-t1x9gknd 641 9 at at IN cord-010119-t1x9gknd 641 10 risk risk NN cord-010119-t1x9gknd 641 11 for for IN cord-010119-t1x9gknd 641 12 acquiring acquire VBG cord-010119-t1x9gknd 641 13 preventable preventable JJ cord-010119-t1x9gknd 641 14 infections infection NNS cord-010119-t1x9gknd 641 15 . . . cord-010119-t1x9gknd 642 1 The the DT cord-010119-t1x9gknd 642 2 primary primary JJ cord-010119-t1x9gknd 642 3 aim aim NN cord-010119-t1x9gknd 642 4 of of IN cord-010119-t1x9gknd 642 5 this this DT cord-010119-t1x9gknd 642 6 project project NN cord-010119-t1x9gknd 642 7 was be VBD cord-010119-t1x9gknd 642 8 to to TO cord-010119-t1x9gknd 642 9 determine determine VB cord-010119-t1x9gknd 642 10 MMR MMR NNP cord-010119-t1x9gknd 642 11 vaccination vaccination NN cord-010119-t1x9gknd 642 12 immunogenicity immunogenicity NN cord-010119-t1x9gknd 642 13 in in IN cord-010119-t1x9gknd 642 14 patients patient NNS cord-010119-t1x9gknd 642 15 chronically chronically RB cord-010119-t1x9gknd 642 16 transfused transfuse VBN cord-010119-t1x9gknd 642 17 with with IN cord-010119-t1x9gknd 642 18 RBC RBC NNP cord-010119-t1x9gknd 642 19 . . . cord-010119-t1x9gknd 643 1 Study Study NNP cord-010119-t1x9gknd 643 2 Design Design NNP cord-010119-t1x9gknd 643 3 / / SYM cord-010119-t1x9gknd 643 4 Method method NN cord-010119-t1x9gknd 643 5 : : : cord-010119-t1x9gknd 644 1 Medical medical JJ cord-010119-t1x9gknd 644 2 charts chart NNS cord-010119-t1x9gknd 644 3 were be VBD cord-010119-t1x9gknd 644 4 reviewed review VBN cord-010119-t1x9gknd 644 5 for for IN cord-010119-t1x9gknd 644 6 vaccination vaccination NN cord-010119-t1x9gknd 644 7 and and CC cord-010119-t1x9gknd 644 8 transfusion transfusion NN cord-010119-t1x9gknd 644 9 histories history NNS cord-010119-t1x9gknd 644 10 . . . cord-010119-t1x9gknd 645 1 MMR MMR NNP cord-010119-t1x9gknd 645 2 - - HYPH cord-010119-t1x9gknd 645 3 specific specific JJ cord-010119-t1x9gknd 645 4 antibodies antibody NNS cord-010119-t1x9gknd 645 5 were be VBD cord-010119-t1x9gknd 645 6 quantified quantify VBN cord-010119-t1x9gknd 645 7 in in IN cord-010119-t1x9gknd 645 8 28 28 CD cord-010119-t1x9gknd 645 9 pediatric pediatric JJ cord-010119-t1x9gknd 645 10 patients patient NNS cord-010119-t1x9gknd 645 11 who who WP cord-010119-t1x9gknd 645 12 received receive VBD cord-010119-t1x9gknd 645 13 both both DT cord-010119-t1x9gknd 645 14 doses dose NNS cord-010119-t1x9gknd 645 15 of of IN cord-010119-t1x9gknd 645 16 the the DT cord-010119-t1x9gknd 645 17 MMR MMR NNP cord-010119-t1x9gknd 645 18 vaccine vaccine NN cord-010119-t1x9gknd 645 19 at at IN cord-010119-t1x9gknd 645 20 12 12 CD cord-010119-t1x9gknd 645 21 and and CC cord-010119-t1x9gknd 645 22 18 18 CD cord-010119-t1x9gknd 645 23 months month NNS cord-010119-t1x9gknd 645 24 of of IN cord-010119-t1x9gknd 645 25 age age NN cord-010119-t1x9gknd 645 26 while while IN cord-010119-t1x9gknd 645 27 they -PRON- PRP cord-010119-t1x9gknd 645 28 were be VBD cord-010119-t1x9gknd 645 29 on on IN cord-010119-t1x9gknd 645 30 a a DT cord-010119-t1x9gknd 645 31 chronic chronic JJ cord-010119-t1x9gknd 645 32 RBC RBC NNP cord-010119-t1x9gknd 645 33 transfusion transfusion NN cord-010119-t1x9gknd 645 34 program program NN cord-010119-t1x9gknd 645 35 for for IN cord-010119-t1x9gknd 645 36 sickle sickle NN cord-010119-t1x9gknd 645 37 cell cell NN cord-010119-t1x9gknd 645 38 disease disease NN cord-010119-t1x9gknd 645 39 , , , cord-010119-t1x9gknd 645 40 B b NN cord-010119-t1x9gknd 645 41 - - HYPH cord-010119-t1x9gknd 645 42 thalassemia thalassemia NN cord-010119-t1x9gknd 645 43 major major NN cord-010119-t1x9gknd 645 44 , , , cord-010119-t1x9gknd 645 45 Diamond Diamond NNP cord-010119-t1x9gknd 645 46 - - HYPH cord-010119-t1x9gknd 645 47 Blackfan Blackfan NNP cord-010119-t1x9gknd 645 48 anemia anemia NN cord-010119-t1x9gknd 645 49 or or CC cord-010119-t1x9gknd 645 50 pyruvate pyruvate NN cord-010119-t1x9gknd 645 51 kinase kinase NN cord-010119-t1x9gknd 645 52 deficiency deficiency NN cord-010119-t1x9gknd 645 53 . . . cord-010119-t1x9gknd 646 1 There there EX cord-010119-t1x9gknd 646 2 was be VBD cord-010119-t1x9gknd 646 3 no no DT cord-010119-t1x9gknd 646 4 formal formal JJ cord-010119-t1x9gknd 646 5 control control NN cord-010119-t1x9gknd 646 6 group group NN cord-010119-t1x9gknd 646 7 ; ; : cord-010119-t1x9gknd 646 8 long long JJ cord-010119-t1x9gknd 646 9 - - HYPH cord-010119-t1x9gknd 646 10 term term NN cord-010119-t1x9gknd 646 11 immunity immunity NN cord-010119-t1x9gknd 646 12 rates rate NNS cord-010119-t1x9gknd 646 13 in in IN cord-010119-t1x9gknd 646 14 the the DT cord-010119-t1x9gknd 646 15 literature literature NN cord-010119-t1x9gknd 646 16 are be VBP cord-010119-t1x9gknd 646 17 ! ! . cord-010119-t1x9gknd 647 1 90 90 CD cord-010119-t1x9gknd 647 2 % % NN cord-010119-t1x9gknd 647 3 for for IN cord-010119-t1x9gknd 647 4 all all DT cord-010119-t1x9gknd 647 5 MMR MMR NNP cord-010119-t1x9gknd 647 6 components component NNS cord-010119-t1x9gknd 647 7 . . . cord-010119-t1x9gknd 648 1 Results result NNS cord-010119-t1x9gknd 649 1 /Finding /finde VBG cord-010119-t1x9gknd 649 2 : : : cord-010119-t1x9gknd 649 3 Table table NN cord-010119-t1x9gknd 649 4 1 1 CD cord-010119-t1x9gknd 649 5 shows show VBZ cord-010119-t1x9gknd 649 6 immunogenicity immunogenicity NN cord-010119-t1x9gknd 649 7 to to IN cord-010119-t1x9gknd 649 8 vaccine vaccine NN cord-010119-t1x9gknd 649 9 components component NNS cord-010119-t1x9gknd 649 10 . . . cord-010119-t1x9gknd 650 1 Delays delay NNS cord-010119-t1x9gknd 650 2 between between IN cord-010119-t1x9gknd 650 3 vaccination vaccination NN cord-010119-t1x9gknd 650 4 and and CC cord-010119-t1x9gknd 650 5 serology serology NN cord-010119-t1x9gknd 650 6 testing testing NN cord-010119-t1x9gknd 650 7 averaged average VBD cord-010119-t1x9gknd 650 8 6.8 6.8 CD cord-010119-t1x9gknd 650 9 years year NNS cord-010119-t1x9gknd 650 10 ( ( -LRB- cord-010119-t1x9gknd 650 11 0.5 0.5 CD cord-010119-t1x9gknd 650 12 to to TO cord-010119-t1x9gknd 650 13 16.5 16.5 CD cord-010119-t1x9gknd 650 14 years year NNS cord-010119-t1x9gknd 650 15 ) ) -RRB- cord-010119-t1x9gknd 650 16 . . . cord-010119-t1x9gknd 651 1 Thirteen thirteen CD cord-010119-t1x9gknd 651 2 patients patient NNS cord-010119-t1x9gknd 651 3 ( ( -LRB- cord-010119-t1x9gknd 651 4 46 46 CD cord-010119-t1x9gknd 651 5 % % NN cord-010119-t1x9gknd 651 6 ) ) -RRB- cord-010119-t1x9gknd 651 7 were be VBD cord-010119-t1x9gknd 651 8 chronically chronically RB cord-010119-t1x9gknd 651 9 transfused transfuse VBN cord-010119-t1x9gknd 651 10 at at IN cord-010119-t1x9gknd 651 11 the the DT cord-010119-t1x9gknd 651 12 time time NN cord-010119-t1x9gknd 651 13 of of IN cord-010119-t1x9gknd 651 14 serology serology NN cord-010119-t1x9gknd 651 15 . . . cord-010119-t1x9gknd 652 1 Twenty twenty CD cord-010119-t1x9gknd 652 2 - - HYPH cord-010119-t1x9gknd 652 3 three three CD cord-010119-t1x9gknd 652 4 patients patient NNS cord-010119-t1x9gknd 652 5 ( ( -LRB- cord-010119-t1x9gknd 652 6 82 82 CD cord-010119-t1x9gknd 652 7 % % NN cord-010119-t1x9gknd 652 8 ) ) -RRB- cord-010119-t1x9gknd 652 9 seroconverted seroconverte VBD cord-010119-t1x9gknd 652 10 to to IN cord-010119-t1x9gknd 652 11 at at RB cord-010119-t1x9gknd 652 12 least least RBS cord-010119-t1x9gknd 652 13 one one CD cord-010119-t1x9gknd 652 14 of of IN cord-010119-t1x9gknd 652 15 the the DT cord-010119-t1x9gknd 652 16 vaccine vaccine NN cord-010119-t1x9gknd 652 17 components component NNS cord-010119-t1x9gknd 652 18 . . . cord-010119-t1x9gknd 653 1 Conclusion conclusion NN cord-010119-t1x9gknd 653 2 : : : cord-010119-t1x9gknd 654 1 To to IN cord-010119-t1x9gknd 654 2 the the DT cord-010119-t1x9gknd 654 3 best good JJS cord-010119-t1x9gknd 654 4 of of IN cord-010119-t1x9gknd 654 5 our -PRON- PRP$ cord-010119-t1x9gknd 654 6 knowledge knowledge NN cord-010119-t1x9gknd 654 7 , , , cord-010119-t1x9gknd 654 8 this this DT cord-010119-t1x9gknd 654 9 is be VBZ cord-010119-t1x9gknd 654 10 the the DT cord-010119-t1x9gknd 654 11 first first JJ cord-010119-t1x9gknd 654 12 study study NN cord-010119-t1x9gknd 654 13 designed design VBN cord-010119-t1x9gknd 654 14 to to TO cord-010119-t1x9gknd 654 15 measure measure VB cord-010119-t1x9gknd 654 16 the the DT cord-010119-t1x9gknd 654 17 effect effect NN cord-010119-t1x9gknd 654 18 of of IN cord-010119-t1x9gknd 654 19 RBC RBC NNP cord-010119-t1x9gknd 654 20 transfusions transfusion NNS cord-010119-t1x9gknd 654 21 on on IN cord-010119-t1x9gknd 654 22 MMR MMR NNP cord-010119-t1x9gknd 654 23 vaccine vaccine NN cord-010119-t1x9gknd 654 24 immunogenicity immunogenicity NN cord-010119-t1x9gknd 654 25 . . . cord-010119-t1x9gknd 655 1 Although although IN cord-010119-t1x9gknd 655 2 lower low JJR cord-010119-t1x9gknd 655 3 than than IN cord-010119-t1x9gknd 655 4 the the DT cord-010119-t1x9gknd 655 5 rates rate NNS cord-010119-t1x9gknd 655 6 reported report VBN cord-010119-t1x9gknd 655 7 in in IN cord-010119-t1x9gknd 655 8 the the DT cord-010119-t1x9gknd 655 9 literature literature NN cord-010119-t1x9gknd 655 10 , , , cord-010119-t1x9gknd 655 11 the the DT cord-010119-t1x9gknd 655 12 results result NNS cord-010119-t1x9gknd 655 13 suggest suggest VBP cord-010119-t1x9gknd 655 14 a a DT cord-010119-t1x9gknd 655 15 high high JJ cord-010119-t1x9gknd 655 16 rate rate NN cord-010119-t1x9gknd 655 17 of of IN cord-010119-t1x9gknd 655 18 immunogenicity immunogenicity NN cord-010119-t1x9gknd 655 19 to to IN cord-010119-t1x9gknd 655 20 each each DT cord-010119-t1x9gknd 655 21 component component NN cord-010119-t1x9gknd 655 22 of of IN cord-010119-t1x9gknd 655 23 the the DT cord-010119-t1x9gknd 655 24 MMR MMR NNP cord-010119-t1x9gknd 655 25 vaccine vaccine NN cord-010119-t1x9gknd 655 26 in in IN cord-010119-t1x9gknd 655 27 chronically chronically RB cord-010119-t1x9gknd 655 28 transfused transfuse VBN cord-010119-t1x9gknd 655 29 patients patient NNS cord-010119-t1x9gknd 655 30 immunized immunize VBN cord-010119-t1x9gknd 655 31 prior prior RB cord-010119-t1x9gknd 655 32 to to IN cord-010119-t1x9gknd 655 33 6 6 CD cord-010119-t1x9gknd 655 34 months month NNS cord-010119-t1x9gknd 655 35 posttransfusion posttransfusion NN cord-010119-t1x9gknd 655 36 . . . cord-010119-t1x9gknd 656 1 Weighing weigh VBG cord-010119-t1x9gknd 656 2 the the DT cord-010119-t1x9gknd 656 3 risks risk NNS cord-010119-t1x9gknd 656 4 and and CC cord-010119-t1x9gknd 656 5 benefits benefit NNS cord-010119-t1x9gknd 656 6 of of IN cord-010119-t1x9gknd 656 7 disease disease NN cord-010119-t1x9gknd 656 8 prevention prevention NN cord-010119-t1x9gknd 656 9 in in IN cord-010119-t1x9gknd 656 10 a a DT cord-010119-t1x9gknd 656 11 highly highly RB cord-010119-t1x9gknd 656 12 vulnerable vulnerable JJ cord-010119-t1x9gknd 656 13 population population NN cord-010119-t1x9gknd 656 14 , , , cord-010119-t1x9gknd 656 15 and and CC cord-010119-t1x9gknd 656 16 taking take VBG cord-010119-t1x9gknd 656 17 into into IN cord-010119-t1x9gknd 656 18 account account NN cord-010119-t1x9gknd 656 19 the the DT cord-010119-t1x9gknd 656 20 aforementioned aforementioned JJ cord-010119-t1x9gknd 656 21 results result NNS cord-010119-t1x9gknd 656 22 , , , cord-010119-t1x9gknd 656 23 a a DT cord-010119-t1x9gknd 656 24 reevaluation reevaluation NN cord-010119-t1x9gknd 656 25 of of IN cord-010119-t1x9gknd 656 26 immunization immunization NN cord-010119-t1x9gknd 656 27 delays delay NNS cord-010119-t1x9gknd 656 28 post post VBP cord-010119-t1x9gknd 656 29 RBC RBC NNP cord-010119-t1x9gknd 656 30 transfusions transfusion NNS cord-010119-t1x9gknd 656 31 is be VBZ cord-010119-t1x9gknd 656 32 called call VBN cord-010119-t1x9gknd 656 33 for for IN cord-010119-t1x9gknd 656 34 in in IN cord-010119-t1x9gknd 656 35 chronically chronically RB cord-010119-t1x9gknd 656 36 transfused transfuse VBN cord-010119-t1x9gknd 656 37 infants infant NNS cord-010119-t1x9gknd 656 38 . . . cord-010119-t1x9gknd 657 1 Post post JJ cord-010119-t1x9gknd 657 2 - - JJ cord-010119-t1x9gknd 657 3 vaccination vaccination NN cord-010119-t1x9gknd 657 4 serology serology NN cord-010119-t1x9gknd 657 5 should should MD cord-010119-t1x9gknd 657 6 be be VB cord-010119-t1x9gknd 657 7 considered consider VBN cord-010119-t1x9gknd 657 8 . . . cord-010119-t1x9gknd 658 1 Cold Cold NNP cord-010119-t1x9gknd 658 2 Stored store VBN cord-010119-t1x9gknd 659 1 Uncrossmatched Uncrossmatched NNP cord-010119-t1x9gknd 659 2 Whole whole JJ cord-010119-t1x9gknd 659 3 Blood blood NN cord-010119-t1x9gknd 659 4 Can Can MD cord-010119-t1x9gknd 659 5 be be VB cord-010119-t1x9gknd 659 6 Safely safely RB cord-010119-t1x9gknd 659 7 Administered administer VBN cord-010119-t1x9gknd 659 8 to to IN cord-010119-t1x9gknd 659 9 Pediatric Pediatric NNP cord-010119-t1x9gknd 659 10 Trauma Trauma NNP cord-010119-t1x9gknd 659 11 Patients Patients NNP cord-010119-t1x9gknd 659 12 Christine Christine NNP cord-010119-t1x9gknd 659 13 M M NNP cord-010119-t1x9gknd 659 14 Leeper Leeper NNP cord-010119-t1x9gknd 659 15 1,2 1,2 CD cord-010119-t1x9gknd 659 16 , , , cord-010119-t1x9gknd 659 17 Franklyn Franklyn NNP cord-010119-t1x9gknd 659 18 Cladis Cladis NNP cord-010119-t1x9gknd 659 19 2 2 CD cord-010119-t1x9gknd 659 20 , , , cord-010119-t1x9gknd 659 21 Richard Richard NNP cord-010119-t1x9gknd 659 22 Saladino Saladino NNP cord-010119-t1x9gknd 659 23 2 2 CD cord-010119-t1x9gknd 659 24 , , , cord-010119-t1x9gknd 659 25 Darrell Darrell NNP cord-010119-t1x9gknd 659 26 Triulzi Triulzi NNP cord-010119-t1x9gknd 659 27 3 3 CD cord-010119-t1x9gknd 659 28 , , , cord-010119-t1x9gknd 659 29 Barbara Barbara NNP cord-010119-t1x9gknd 659 30 A A NNP cord-010119-t1x9gknd 659 31 Gaines Gaines NNP cord-010119-t1x9gknd 659 32 2 2 CD cord-010119-t1x9gknd 659 33 and and CC cord-010119-t1x9gknd 659 34 Mark Mark NNP cord-010119-t1x9gknd 659 35 Yazer Yazer NNP cord-010119-t1x9gknd 659 36 * * NFP cord-010119-t1x9gknd 659 37 1 1 CD cord-010119-t1x9gknd 659 38 . . . cord-010119-t1x9gknd 659 39 1 1 CD cord-010119-t1x9gknd 659 40 University University NNP cord-010119-t1x9gknd 659 41 of of IN cord-010119-t1x9gknd 659 42 Pittsburgh Pittsburgh NNP cord-010119-t1x9gknd 659 43 , , , cord-010119-t1x9gknd 659 44 2 2 CD cord-010119-t1x9gknd 659 45 Children Children NNPS cord-010119-t1x9gknd 659 46 's 's POS cord-010119-t1x9gknd 659 47 Hospital Hospital NNP cord-010119-t1x9gknd 659 48 of of IN cord-010119-t1x9gknd 659 49 Pittsburgh Pittsburgh NNP cord-010119-t1x9gknd 659 50 of of IN cord-010119-t1x9gknd 659 51 UPMC UPMC NNP cord-010119-t1x9gknd 659 52 , , , cord-010119-t1x9gknd 660 1 3 3 CD cord-010119-t1x9gknd 660 2 Institute Institute NNP cord-010119-t1x9gknd 660 3 For for IN cord-010119-t1x9gknd 660 4 Transfusion Transfusion NNP cord-010119-t1x9gknd 660 5 Medicine Medicine NNP cord-010119-t1x9gknd 660 6 Background Background NNP cord-010119-t1x9gknd 660 7 / / SYM cord-010119-t1x9gknd 660 8 Case Case NNP cord-010119-t1x9gknd 660 9 Studies Studies NNPS cord-010119-t1x9gknd 660 10 : : : cord-010119-t1x9gknd 661 1 The the DT cord-010119-t1x9gknd 661 2 use use NN cord-010119-t1x9gknd 661 3 of of IN cord-010119-t1x9gknd 661 4 uncrossmatched uncrossmatched JJ cord-010119-t1x9gknd 661 5 cold cold NN cord-010119-t1x9gknd 661 6 stored store VBD cord-010119-t1x9gknd 661 7 whole whole JJ cord-010119-t1x9gknd 661 8 blood blood NN cord-010119-t1x9gknd 661 9 ( ( -LRB- cord-010119-t1x9gknd 661 10 WB WB NNP cord-010119-t1x9gknd 661 11 ) ) -RRB- cord-010119-t1x9gknd 661 12 is be VBZ cord-010119-t1x9gknd 661 13 becoming become VBG cord-010119-t1x9gknd 661 14 increasingly increasingly RB cord-010119-t1x9gknd 661 15 popular popular JJ cord-010119-t1x9gknd 661 16 in in IN cord-010119-t1x9gknd 661 17 the the DT cord-010119-t1x9gknd 661 18 initial initial JJ cord-010119-t1x9gknd 661 19 resuscitation resuscitation NN cord-010119-t1x9gknd 661 20 of of IN cord-010119-t1x9gknd 661 21 trauma trauma NN cord-010119-t1x9gknd 661 22 patients patient NNS cord-010119-t1x9gknd 661 23 without without IN cord-010119-t1x9gknd 661 24 a a DT cord-010119-t1x9gknd 661 25 current current JJ cord-010119-t1x9gknd 661 26 ABO ABO NNP cord-010119-t1x9gknd 661 27 group group NN cord-010119-t1x9gknd 661 28 . . . cord-010119-t1x9gknd 662 1 WB WB NNP cord-010119-t1x9gknd 662 2 has have VBZ cord-010119-t1x9gknd 662 3 advantages advantage NNS cord-010119-t1x9gknd 662 4 over over IN cord-010119-t1x9gknd 662 5 conventional conventional JJ cord-010119-t1x9gknd 662 6 component component NN cord-010119-t1x9gknd 662 7 therapy therapy NN cord-010119-t1x9gknd 662 8 including include VBG cord-010119-t1x9gknd 662 9 greater great JJR cord-010119-t1x9gknd 662 10 platelet platelet NN cord-010119-t1x9gknd 662 11 and and CC cord-010119-t1x9gknd 662 12 factor factor NN cord-010119-t1x9gknd 662 13 concentrations concentration NNS cord-010119-t1x9gknd 662 14 , , , cord-010119-t1x9gknd 662 15 as as RB cord-010119-t1x9gknd 662 16 well well RB cord-010119-t1x9gknd 662 17 as as IN cord-010119-t1x9gknd 662 18 less less JJR cord-010119-t1x9gknd 662 19 saline saline NN cord-010119-t1x9gknd 662 20 and and CC cord-010119-t1x9gknd 662 21 additive additive NN cord-010119-t1x9gknd 662 22 solution solution NN cord-010119-t1x9gknd 662 23 compared compare VBN cord-010119-t1x9gknd 662 24 to to IN cord-010119-t1x9gknd 662 25 an an DT cord-010119-t1x9gknd 662 26 equivalent equivalent JJ cord-010119-t1x9gknd 662 27 volume volume NN cord-010119-t1x9gknd 662 28 of of IN cord-010119-t1x9gknd 662 29 reconstituted reconstitute VBN cord-010119-t1x9gknd 662 30 whole whole JJ cord-010119-t1x9gknd 662 31 blood blood NN cord-010119-t1x9gknd 662 32 . . . cord-010119-t1x9gknd 663 1 This this DT cord-010119-t1x9gknd 663 2 report report NN cord-010119-t1x9gknd 663 3 details detail VBZ cord-010119-t1x9gknd 663 4 the the DT cord-010119-t1x9gknd 663 5 initial initial JJ cord-010119-t1x9gknd 663 6 use use NN cord-010119-t1x9gknd 663 7 of of IN cord-010119-t1x9gknd 663 8 WB WB NNP cord-010119-t1x9gknd 663 9 in in IN cord-010119-t1x9gknd 663 10 pediatric pediatric JJ cord-010119-t1x9gknd 663 11 trauma trauma NN cord-010119-t1x9gknd 663 12 patients patient NNS cord-010119-t1x9gknd 663 13 . . . cord-010119-t1x9gknd 664 1 Study Study NNP cord-010119-t1x9gknd 664 2 Design Design NNP cord-010119-t1x9gknd 664 3 / / SYM cord-010119-t1x9gknd 664 4 Method method NN cord-010119-t1x9gknd 664 5 : : : cord-010119-t1x9gknd 664 6 Pediatric pediatric JJ cord-010119-t1x9gknd 664 7 trauma trauma NN cord-010119-t1x9gknd 664 8 patients patient NNS cord-010119-t1x9gknd 664 9 ! ! . cord-010119-t1x9gknd 665 1 3 3 CD cord-010119-t1x9gknd 665 2 years year NNS cord-010119-t1x9gknd 665 3 old old JJ cord-010119-t1x9gknd 665 4 and and CC cord-010119-t1x9gknd 665 5 ! ! . cord-010119-t1x9gknd 666 1 15 15 CD cord-010119-t1x9gknd 666 2 kg kg NNS cord-010119-t1x9gknd 666 3 with with IN cord-010119-t1x9gknd 666 4 evidence evidence NN cord-010119-t1x9gknd 666 5 of of IN cord-010119-t1x9gknd 666 6 hemorrhagic hemorrhagic JJ cord-010119-t1x9gknd 666 7 shock shock NN cord-010119-t1x9gknd 666 8 were be VBD cord-010119-t1x9gknd 666 9 eligible eligible JJ cord-010119-t1x9gknd 666 10 to to TO cord-010119-t1x9gknd 666 11 receive receive VB cord-010119-t1x9gknd 666 12 up up IN cord-010119-t1x9gknd 666 13 to to TO cord-010119-t1x9gknd 666 14 20 20 CD cord-010119-t1x9gknd 666 15 cc cc NNS cord-010119-t1x9gknd 666 16 / / SYM cord-010119-t1x9gknd 666 17 kg kg NNS cord-010119-t1x9gknd 666 18 of of IN cord-010119-t1x9gknd 666 19 cold cold JJ cord-010119-t1x9gknd 666 20 stored store VBN cord-010119-t1x9gknd 666 21 , , , cord-010119-t1x9gknd 666 22 leukoreduced leukoreduced JJ cord-010119-t1x9gknd 666 23 group group NN cord-010119-t1x9gknd 667 1 O o UH cord-010119-t1x9gknd 667 2 negative negative JJ cord-010119-t1x9gknd 667 3 WB WB NNP cord-010119-t1x9gknd 667 4 during during IN cord-010119-t1x9gknd 667 5 their -PRON- PRP$ cord-010119-t1x9gknd 667 6 initial initial JJ cord-010119-t1x9gknd 667 7 resuscitation resuscitation NN cord-010119-t1x9gknd 667 8 . . . cord-010119-t1x9gknd 668 1 All all DT cord-010119-t1x9gknd 668 2 WB WB NNP cord-010119-t1x9gknd 668 3 units unit NNS cord-010119-t1x9gknd 668 4 had have VBD cord-010119-t1x9gknd 668 5 a a DT cord-010119-t1x9gknd 668 6 low low JJ cord-010119-t1x9gknd 668 7 titer titer NN cord-010119-t1x9gknd 668 8 of of IN cord-010119-t1x9gknd 668 9 anti anti JJ cord-010119-t1x9gknd 668 10 - - JJ cord-010119-t1x9gknd 668 11 A a JJ cord-010119-t1x9gknd 668 12 and and CC cord-010119-t1x9gknd 668 13 -B -b ADD cord-010119-t1x9gknd 668 14 ( ( -LRB- cord-010119-t1x9gknd 668 15 < < XX cord-010119-t1x9gknd 668 16 50 50 CD cord-010119-t1x9gknd 668 17 ) ) -RRB- cord-010119-t1x9gknd 668 18 to to TO cord-010119-t1x9gknd 668 19 reduce reduce VB cord-010119-t1x9gknd 668 20 the the DT cord-010119-t1x9gknd 668 21 likelihood likelihood NN cord-010119-t1x9gknd 668 22 of of IN cord-010119-t1x9gknd 668 23 hemolysis hemolysis NN cord-010119-t1x9gknd 668 24 in in IN cord-010119-t1x9gknd 668 25 non non JJ cord-010119-t1x9gknd 668 26 - - JJ cord-010119-t1x9gknd 668 27 group group JJ cord-010119-t1x9gknd 668 28 O o NN cord-010119-t1x9gknd 668 29 recipients recipient NNS cord-010119-t1x9gknd 668 30 . . . cord-010119-t1x9gknd 669 1 Biochemical biochemical JJ cord-010119-t1x9gknd 669 2 markers marker NNS cord-010119-t1x9gknd 669 3 of of IN cord-010119-t1x9gknd 669 4 hemolysis hemolysis NN cord-010119-t1x9gknd 669 5 were be VBD cord-010119-t1x9gknd 669 6 measured measure VBN cord-010119-t1x9gknd 669 7 on on IN cord-010119-t1x9gknd 669 8 the the DT cord-010119-t1x9gknd 669 9 day day NN cord-010119-t1x9gknd 669 10 of of IN cord-010119-t1x9gknd 669 11 WB WB NNP cord-010119-t1x9gknd 669 12 transfusion transfusion NN cord-010119-t1x9gknd 669 13 and and CC cord-010119-t1x9gknd 669 14 the the DT cord-010119-t1x9gknd 669 15 following follow VBG cord-010119-t1x9gknd 669 16 two two CD cord-010119-t1x9gknd 669 17 days day NNS cord-010119-t1x9gknd 669 18 . . . cord-010119-t1x9gknd 670 1 Admission admission NN cord-010119-t1x9gknd 670 2 thromboelastograms thromboelastogram NNS cord-010119-t1x9gknd 670 3 were be VBD cord-010119-t1x9gknd 670 4 obtained obtain VBN cord-010119-t1x9gknd 670 5 and and CC cord-010119-t1x9gknd 670 6 repeated repeat VBN cord-010119-t1x9gknd 670 7 as as IN cord-010119-t1x9gknd 670 8 necessary necessary JJ cord-010119-t1x9gknd 670 9 during during IN cord-010119-t1x9gknd 670 10 the the DT cord-010119-t1x9gknd 670 11 resuscitation resuscitation NN cord-010119-t1x9gknd 670 12 . . . cord-010119-t1x9gknd 671 1 After after IN cord-010119-t1x9gknd 671 2 receipt receipt NN cord-010119-t1x9gknd 671 3 of of IN cord-010119-t1x9gknd 671 4 the the DT cord-010119-t1x9gknd 671 5 maximum maximum JJ cord-010119-t1x9gknd 671 6 quantity quantity NN cord-010119-t1x9gknd 671 7 of of IN cord-010119-t1x9gknd 671 8 WB WB NNP cord-010119-t1x9gknd 671 9 , , , cord-010119-t1x9gknd 671 10 conventional conventional JJ cord-010119-t1x9gknd 671 11 components component NNS cord-010119-t1x9gknd 671 12 were be VBD cord-010119-t1x9gknd 671 13 utilized utilize VBN cord-010119-t1x9gknd 671 14 . . . cord-010119-t1x9gknd 672 1 Results result NNS cord-010119-t1x9gknd 672 2 / / SYM cord-010119-t1x9gknd 672 3 Finding finding NN cord-010119-t1x9gknd 672 4 : : : cord-010119-t1x9gknd 673 1 In in IN cord-010119-t1x9gknd 673 2 approximately approximately RB cord-010119-t1x9gknd 673 3 11 11 CD cord-010119-t1x9gknd 673 4 months month NNS cord-010119-t1x9gknd 673 5 , , , cord-010119-t1x9gknd 673 6 15 15 CD cord-010119-t1x9gknd 673 7 trauma trauma NN cord-010119-t1x9gknd 673 8 patients patient NNS cord-010119-t1x9gknd 673 9 received receive VBD cord-010119-t1x9gknd 673 10 WB WB NNP cord-010119-t1x9gknd 673 11 : : : cord-010119-t1x9gknd 674 1 7 7 CD cord-010119-t1x9gknd 674 2 group group NN cord-010119-t1x9gknd 674 3 O o NN cord-010119-t1x9gknd 674 4 and and CC cord-010119-t1x9gknd 674 5 8 8 CD cord-010119-t1x9gknd 674 6 group group NN cord-010119-t1x9gknd 674 7 A a DT cord-010119-t1x9gknd 674 8 recipients recipient NNS cord-010119-t1x9gknd 674 9 , , , cord-010119-t1x9gknd 674 10 53 53 CD cord-010119-t1x9gknd 674 11 % % NN cord-010119-t1x9gknd 674 12 male male NN cord-010119-t1x9gknd 674 13 , , , cord-010119-t1x9gknd 674 14 median median JJ cord-010119-t1x9gknd 674 15 ( ( -LRB- cord-010119-t1x9gknd 674 16 IQR IQR NNP cord-010119-t1x9gknd 674 17 ) ) -RRB- cord-010119-t1x9gknd 674 18 age age NN cord-010119-t1x9gknd 674 19 was be VBD cord-010119-t1x9gknd 674 20 11 11 CD cord-010119-t1x9gknd 674 21 ( ( -LRB- cord-010119-t1x9gknd 674 22 4.5 4.5 CD cord-010119-t1x9gknd 674 23 - - SYM cord-010119-t1x9gknd 674 24 14 14 CD cord-010119-t1x9gknd 674 25 ) ) -RRB- cord-010119-t1x9gknd 674 26 and and CC cord-010119-t1x9gknd 674 27 73 73 CD cord-010119-t1x9gknd 674 28 % % NN cord-010119-t1x9gknd 674 29 blunt blunt JJ cord-010119-t1x9gknd 674 30 trauma trauma NN cord-010119-t1x9gknd 674 31 mechanism mechanism NN cord-010119-t1x9gknd 674 32 . . . cord-010119-t1x9gknd 675 1 Patients patient NNS cord-010119-t1x9gknd 675 2 were be VBD cord-010119-t1x9gknd 675 3 severelyinjured severelyinjure VBN cord-010119-t1x9gknd 675 4 with with IN cord-010119-t1x9gknd 675 5 a a DT cord-010119-t1x9gknd 675 6 median median NN cord-010119-t1x9gknd 675 7 ( ( -LRB- cord-010119-t1x9gknd 675 8 IQR iqr NN cord-010119-t1x9gknd 675 9 ) ) -RRB- cord-010119-t1x9gknd 676 1 Injury injury NN cord-010119-t1x9gknd 676 2 Severity severity NN cord-010119-t1x9gknd 676 3 Score Score NNP cord-010119-t1x9gknd 676 4 of of IN cord-010119-t1x9gknd 676 5 36 36 CD cord-010119-t1x9gknd 676 6 ( ( -LRB- cord-010119-t1x9gknd 676 7 22 22 CD cord-010119-t1x9gknd 676 8 - - SYM cord-010119-t1x9gknd 676 9 51 51 CD cord-010119-t1x9gknd 676 10 ) ) -RRB- cord-010119-t1x9gknd 676 11 and and CC cord-010119-t1x9gknd 676 12 47 47 CD cord-010119-t1x9gknd 676 13 % % NN cord-010119-t1x9gknd 676 14 mortality mortality NN cord-010119-t1x9gknd 676 15 rate rate NN cord-010119-t1x9gknd 676 16 . . . cord-010119-t1x9gknd 677 1 The the DT cord-010119-t1x9gknd 677 2 median median NN cord-010119-t1x9gknd 677 3 ( ( -LRB- cord-010119-t1x9gknd 677 4 IQR IQR NNP cord-010119-t1x9gknd 677 5 ) ) -RRB- cord-010119-t1x9gknd 677 6 quantity quantity NN cord-010119-t1x9gknd 677 7 of of IN cord-010119-t1x9gknd 677 8 WB WB NNP cord-010119-t1x9gknd 677 9 transfused transfuse VBN cord-010119-t1x9gknd 677 10 to to IN cord-010119-t1x9gknd 677 11 group group NN cord-010119-t1x9gknd 677 12 O o NN cord-010119-t1x9gknd 677 13 recipients recipient NNS cord-010119-t1x9gknd 677 14 was be VBD cord-010119-t1x9gknd 678 1 21.9 21.9 CD cord-010119-t1x9gknd 678 2 ( ( -LRB- cord-010119-t1x9gknd 678 3 14.8 14.8 CD cord-010119-t1x9gknd 678 4 - - SYM cord-010119-t1x9gknd 678 5 24.3 24.3 CD cord-010119-t1x9gknd 678 6 ) ) -RRB- cord-010119-t1x9gknd 678 7 ml ml NN cord-010119-t1x9gknd 678 8 / / SYM cord-010119-t1x9gknd 678 9 kg kg NN cord-010119-t1x9gknd 678 10 versus versus IN cord-010119-t1x9gknd 678 11 13.4 13.4 CD cord-010119-t1x9gknd 678 12 ( ( -LRB- cord-010119-t1x9gknd 678 13 9 9 CD cord-010119-t1x9gknd 678 14 - - SYM cord-010119-t1x9gknd 678 15 18 18 CD cord-010119-t1x9gknd 678 16 ) ) -RRB- cord-010119-t1x9gknd 678 17 ml ml NNS cord-010119-t1x9gknd 678 18 / / SYM cord-010119-t1x9gknd 678 19 kg kg NN cord-010119-t1x9gknd 678 20 to to IN cord-010119-t1x9gknd 678 21 non non JJ cord-010119-t1x9gknd 678 22 - - JJ cord-010119-t1x9gknd 678 23 group group JJ cord-010119-t1x9gknd 678 24 O o NN cord-010119-t1x9gknd 678 25 recipients recipient NNS cord-010119-t1x9gknd 678 26 . . . cord-010119-t1x9gknd 679 1 No no DT cord-010119-t1x9gknd 679 2 transfusion transfusion NN cord-010119-t1x9gknd 679 3 reactions reaction NNS cord-010119-t1x9gknd 679 4 were be VBD cord-010119-t1x9gknd 679 5 reported report VBN cord-010119-t1x9gknd 679 6 . . . cord-010119-t1x9gknd 680 1 The the DT cord-010119-t1x9gknd 680 2 mean mean JJ cord-010119-t1x9gknd 680 3 6 6 CD cord-010119-t1x9gknd 680 4 standard standard JJ cord-010119-t1x9gknd 680 5 deviation deviation NN cord-010119-t1x9gknd 680 6 haptoglobin haptoglobin NN cord-010119-t1x9gknd 680 7 concentrations concentration NNS cord-010119-t1x9gknd 680 8 for for IN cord-010119-t1x9gknd 680 9 non non JJ cord-010119-t1x9gknd 680 10 - - JJ cord-010119-t1x9gknd 680 11 group group JJ cord-010119-t1x9gknd 680 12 O o NN cord-010119-t1x9gknd 680 13 recipients recipient NNS cord-010119-t1x9gknd 680 14 was be VBD cord-010119-t1x9gknd 680 15 51.3 51.3 CD cord-010119-t1x9gknd 681 1 6 6 CD cord-010119-t1x9gknd 681 2 14.4 14.4 CD cord-010119-t1x9gknd 681 3 mg mg NNP cord-010119-t1x9gknd 681 4 / / SYM cord-010119-t1x9gknd 681 5 dl dl NNP cord-010119-t1x9gknd 681 6 on on IN cord-010119-t1x9gknd 681 7 day day NN cord-010119-t1x9gknd 681 8 0 0 CD cord-010119-t1x9gknd 681 9 , , , cord-010119-t1x9gknd 682 1 86.3 86.3 CD cord-010119-t1x9gknd 682 2 6 6 CD cord-010119-t1x9gknd 682 3 36.8 36.8 CD cord-010119-t1x9gknd 682 4 mg mg NNP cord-010119-t1x9gknd 682 5 / / SYM cord-010119-t1x9gknd 682 6 dl dl NNP cord-010119-t1x9gknd 682 7 on on IN cord-010119-t1x9gknd 682 8 day day NN cord-010119-t1x9gknd 682 9 1 1 CD cord-010119-t1x9gknd 682 10 , , , cord-010119-t1x9gknd 682 11 and and CC cord-010119-t1x9gknd 682 12 126.9 126.9 CD cord-010119-t1x9gknd 682 13 6 6 CD cord-010119-t1x9gknd 682 14 45.8 45.8 CD cord-010119-t1x9gknd 682 15 mg mg NNP cord-010119-t1x9gknd 682 16 / / SYM cord-010119-t1x9gknd 682 17 dl dl NNP cord-010119-t1x9gknd 682 18 on on IN cord-010119-t1x9gknd 682 19 day day NN cord-010119-t1x9gknd 682 20 2 2 CD cord-010119-t1x9gknd 682 21 ; ; : cord-010119-t1x9gknd 682 22 the the DT cord-010119-t1x9gknd 682 23 corresponding correspond VBG cord-010119-t1x9gknd 682 24 haptoglobin haptoglobin NN cord-010119-t1x9gknd 682 25 concentrations concentration NNS cord-010119-t1x9gknd 682 26 for for IN cord-010119-t1x9gknd 682 27 group group NN cord-010119-t1x9gknd 682 28 O o NN cord-010119-t1x9gknd 682 29 recipients recipient NNS cord-010119-t1x9gknd 682 30 were be VBD cord-010119-t1x9gknd 682 31 51.4 51.4 CD cord-010119-t1x9gknd 682 32 6 6 CD cord-010119-t1x9gknd 682 33 38.0 38.0 CD cord-010119-t1x9gknd 682 34 mg mg NNP cord-010119-t1x9gknd 682 35 / / SYM cord-010119-t1x9gknd 682 36 dl dl NNP cord-010119-t1x9gknd 682 37 , , , cord-010119-t1x9gknd 682 38 84.7 84.7 CD cord-010119-t1x9gknd 682 39 6 6 CD cord-010119-t1x9gknd 682 40 61.5 61.5 CD cord-010119-t1x9gknd 682 41 mg mg NNP cord-010119-t1x9gknd 682 42 / / SYM cord-010119-t1x9gknd 682 43 dl dl NNP cord-010119-t1x9gknd 682 44 , , , cord-010119-t1x9gknd 682 45 and and CC cord-010119-t1x9gknd 682 46 134.8 134.8 CD cord-010119-t1x9gknd 682 47 6 6 CD cord-010119-t1x9gknd 682 48 68.3 68.3 CD cord-010119-t1x9gknd 682 49 mg mg NNP cord-010119-t1x9gknd 682 50 / / SYM cord-010119-t1x9gknd 682 51 dl dl NNP cord-010119-t1x9gknd 682 52 , , , cord-010119-t1x9gknd 682 53 respectively respectively RB cord-010119-t1x9gknd 682 54 ( ( -LRB- cord-010119-t1x9gknd 682 55 p>0.42 p>0.42 VBN cord-010119-t1x9gknd 683 1 for for IN cord-010119-t1x9gknd 683 2 all all DT cord-010119-t1x9gknd 683 3 comparisons comparison NNS cord-010119-t1x9gknd 683 4 ) ) -RRB- cord-010119-t1x9gknd 683 5 . . . cord-010119-t1x9gknd 684 1 Similarly similarly RB cord-010119-t1x9gknd 684 2 there there EX cord-010119-t1x9gknd 684 3 were be VBD cord-010119-t1x9gknd 684 4 no no DT cord-010119-t1x9gknd 684 5 significant significant JJ cord-010119-t1x9gknd 684 6 differences difference NNS cord-010119-t1x9gknd 684 7 in in IN cord-010119-t1x9gknd 684 8 total total JJ cord-010119-t1x9gknd 684 9 bilirubin bilirubin NN cord-010119-t1x9gknd 684 10 , , , cord-010119-t1x9gknd 684 11 LDH LDH NNP cord-010119-t1x9gknd 684 12 , , , cord-010119-t1x9gknd 684 13 creatinine creatinine NN cord-010119-t1x9gknd 684 14 , , , cord-010119-t1x9gknd 684 15 and and CC cord-010119-t1x9gknd 684 16 potassium potassium NN cord-010119-t1x9gknd 684 17 at at IN cord-010119-t1x9gknd 684 18 any any DT cord-010119-t1x9gknd 684 19 time time NN cord-010119-t1x9gknd 684 20 point point NN cord-010119-t1x9gknd 684 21 . . . cord-010119-t1x9gknd 685 1 Regarding regard VBG cord-010119-t1x9gknd 685 2 evaluation evaluation NN cord-010119-t1x9gknd 685 3 of of IN cord-010119-t1x9gknd 685 4 cold cold JJ cord-010119-t1x9gknd 685 5 platelet platelet NN cord-010119-t1x9gknd 685 6 function function NN cord-010119-t1x9gknd 685 7 , , , cord-010119-t1x9gknd 685 8 we -PRON- PRP cord-010119-t1x9gknd 685 9 compared compare VBD cord-010119-t1x9gknd 685 10 the the DT cord-010119-t1x9gknd 685 11 subset subset NN cord-010119-t1x9gknd 685 12 of of IN cord-010119-t1x9gknd 685 13 patients patient NNS cord-010119-t1x9gknd 685 14 who who WP cord-010119-t1x9gknd 685 15 received receive VBD cord-010119-t1x9gknd 685 16 WB WB NNP cord-010119-t1x9gknd 685 17 but but CC cord-010119-t1x9gknd 685 18 no no DT cord-010119-t1x9gknd 685 19 warm warm JJ cord-010119-t1x9gknd 685 20 platelets platelet NNS cord-010119-t1x9gknd 685 21 ( ( -LRB- cord-010119-t1x9gknd 685 22 n57 n57 NN cord-010119-t1x9gknd 685 23 ) ) -RRB- cord-010119-t1x9gknd 685 24 to to IN cord-010119-t1x9gknd 685 25 a a DT cord-010119-t1x9gknd 685 26 historical historical JJ cord-010119-t1x9gknd 685 27 group group NN cord-010119-t1x9gknd 685 28 of of IN cord-010119-t1x9gknd 685 29 pediatric pediatric JJ cord-010119-t1x9gknd 685 30 trauma trauma NN cord-010119-t1x9gknd 685 31 patients patient NNS cord-010119-t1x9gknd 685 32 who who WP cord-010119-t1x9gknd 685 33 received receive VBD cord-010119-t1x9gknd 685 34 conventional conventional JJ cord-010119-t1x9gknd 685 35 components component NNS cord-010119-t1x9gknd 685 36 including include VBG cord-010119-t1x9gknd 685 37 warm warm JJ cord-010119-t1x9gknd 685 38 platelets platelet NNS cord-010119-t1x9gknd 685 39 ( ( -LRB- cord-010119-t1x9gknd 685 40 n514 n514 NNP cord-010119-t1x9gknd 685 41 ) ) -RRB- cord-010119-t1x9gknd 685 42 . . . cord-010119-t1x9gknd 686 1 The the DT cord-010119-t1x9gknd 686 2 mean mean JJ cord-010119-t1x9gknd 686 3 6 6 CD cord-010119-t1x9gknd 686 4 standard standard JJ cord-010119-t1x9gknd 686 5 deviation deviation NN cord-010119-t1x9gknd 686 6 platelet platelet NN cord-010119-t1x9gknd 686 7 volume volume NN cord-010119-t1x9gknd 686 8 administered administer VBN cord-010119-t1x9gknd 686 9 was be VBD cord-010119-t1x9gknd 686 10 112 112 CD cord-010119-t1x9gknd 686 11 6 6 CD cord-010119-t1x9gknd 686 12 24 24 CD cord-010119-t1x9gknd 686 13 cc cc NNS cord-010119-t1x9gknd 686 14 for for IN cord-010119-t1x9gknd 686 15 whole whole JJ cord-010119-t1x9gknd 686 16 blood blood NN cord-010119-t1x9gknd 686 17 recipients recipient NNS cord-010119-t1x9gknd 686 18 versus versus IN cord-010119-t1x9gknd 686 19 147 147 CD cord-010119-t1x9gknd 686 20 6 6 CD cord-010119-t1x9gknd 686 21 68 68 CD cord-010119-t1x9gknd 686 22 cc cc NNS cord-010119-t1x9gknd 686 23 for for IN cord-010119-t1x9gknd 686 24 warm warm JJ cord-010119-t1x9gknd 686 25 platelet platelet NN cord-010119-t1x9gknd 686 26 recipients recipient NNS cord-010119-t1x9gknd 686 27 . . . cord-010119-t1x9gknd 687 1 When when WRB cord-010119-t1x9gknd 687 2 pre pre JJ cord-010119-t1x9gknd 687 3 - - JJ cord-010119-t1x9gknd 687 4 and and CC cord-010119-t1x9gknd 687 5 posttransfusion posttransfusion NN cord-010119-t1x9gknd 687 6 TEG TEG NNP cord-010119-t1x9gknd 687 7 and and CC cord-010119-t1x9gknd 687 8 platelet platelet NN cord-010119-t1x9gknd 687 9 counts count NNS cord-010119-t1x9gknd 687 10 were be VBD cord-010119-t1x9gknd 687 11 analyzed analyze VBN cord-010119-t1x9gknd 687 12 , , , cord-010119-t1x9gknd 687 13 there there EX cord-010119-t1x9gknd 687 14 was be VBD cord-010119-t1x9gknd 687 15 no no DT cord-010119-t1x9gknd 687 16 difference difference NN cord-010119-t1x9gknd 687 17 in in IN cord-010119-t1x9gknd 687 18 median median JJ cord-010119-t1x9gknd 687 19 platelet platelet NN cord-010119-t1x9gknd 687 20 count count NN cord-010119-t1x9gknd 687 21 or or CC cord-010119-t1x9gknd 687 22 TEG TEG NNP cord-010119-t1x9gknd 687 23 maximum maximum JJ cord-010119-t1x9gknd 687 24 amplitude amplitude NN cord-010119-t1x9gknd 687 25 ( ( -LRB- cord-010119-t1x9gknd 687 26 MA MA NNP cord-010119-t1x9gknd 687 27 ) ) -RRB- cord-010119-t1x9gknd 687 28 between between IN cord-010119-t1x9gknd 687 29 cold cold JJ cord-010119-t1x9gknd 687 30 and and CC cord-010119-t1x9gknd 687 31 warm warm JJ cord-010119-t1x9gknd 687 32 platelet platelet NN cord-010119-t1x9gknd 687 33 groups group NNS cord-010119-t1x9gknd 687 34 . . . cord-010119-t1x9gknd 688 1 Conclusion conclusion NN cord-010119-t1x9gknd 688 2 : : : cord-010119-t1x9gknd 688 3 Use use NN cord-010119-t1x9gknd 688 4 of of IN cord-010119-t1x9gknd 688 5 cold cold RB cord-010119-t1x9gknd 688 6 - - HYPH cord-010119-t1x9gknd 688 7 stored store VBN cord-010119-t1x9gknd 688 8 uncrossmatched uncrossmatched JJ cord-010119-t1x9gknd 688 9 whole whole JJ cord-010119-t1x9gknd 688 10 blood blood NN cord-010119-t1x9gknd 688 11 for for IN cord-010119-t1x9gknd 688 12 the the DT cord-010119-t1x9gknd 688 13 resuscitation resuscitation NN cord-010119-t1x9gknd 688 14 of of IN cord-010119-t1x9gknd 688 15 pediatric pediatric JJ cord-010119-t1x9gknd 688 16 trauma trauma NN cord-010119-t1x9gknd 688 17 patients patient NNS cord-010119-t1x9gknd 688 18 is be VBZ cord-010119-t1x9gknd 688 19 feasible feasible JJ cord-010119-t1x9gknd 688 20 , , , cord-010119-t1x9gknd 688 21 acceptable acceptable JJ cord-010119-t1x9gknd 688 22 , , , cord-010119-t1x9gknd 688 23 and and CC cord-010119-t1x9gknd 688 24 appears appear VBZ cord-010119-t1x9gknd 688 25 to to TO cord-010119-t1x9gknd 688 26 be be VB cord-010119-t1x9gknd 688 27 safe safe JJ cord-010119-t1x9gknd 688 28 . . . cord-010119-t1x9gknd 689 1 Receipt receipt NN cord-010119-t1x9gknd 689 2 of of IN cord-010119-t1x9gknd 689 3 low low JJ cord-010119-t1x9gknd 689 4 titer titer NN cord-010119-t1x9gknd 689 5 group group NN cord-010119-t1x9gknd 689 6 O o UH cord-010119-t1x9gknd 689 7 WB WB NNP cord-010119-t1x9gknd 689 8 did do VBD cord-010119-t1x9gknd 689 9 not not RB cord-010119-t1x9gknd 689 10 lead lead VB cord-010119-t1x9gknd 689 11 to to IN cord-010119-t1x9gknd 689 12 detectable detectable JJ cord-010119-t1x9gknd 689 13 hemolysis hemolysis NN cord-010119-t1x9gknd 689 14 amongst amongst IN cord-010119-t1x9gknd 689 15 the the DT cord-010119-t1x9gknd 689 16 non non JJ cord-010119-t1x9gknd 689 17 - - JJ cord-010119-t1x9gknd 689 18 group group JJ cord-010119-t1x9gknd 689 19 O o NN cord-010119-t1x9gknd 689 20 recipients recipient NNS cord-010119-t1x9gknd 689 21 . . . cord-010119-t1x9gknd 690 1 Given give VBN cord-010119-t1x9gknd 690 2 this this DT cord-010119-t1x9gknd 690 3 finding finding NN cord-010119-t1x9gknd 690 4 , , , cord-010119-t1x9gknd 690 5 the the DT cord-010119-t1x9gknd 690 6 maximum maximum JJ cord-010119-t1x9gknd 690 7 quantity quantity NN cord-010119-t1x9gknd 690 8 of of IN cord-010119-t1x9gknd 690 9 WB WB NNP cord-010119-t1x9gknd 690 10 per per IN cord-010119-t1x9gknd 690 11 patients patient NNS cord-010119-t1x9gknd 690 12 will will MD cord-010119-t1x9gknd 690 13 be be VB cord-010119-t1x9gknd 690 14 increased increase VBN cord-010119-t1x9gknd 690 15 to to IN cord-010119-t1x9gknd 690 16 30 30 CD cord-010119-t1x9gknd 690 17 ml ml NNS cord-010119-t1x9gknd 690 18 / / SYM cord-010119-t1x9gknd 690 19 kg kg NNS cord-010119-t1x9gknd 690 20 . . . cord-010119-t1x9gknd 691 1 Identification identification NN cord-010119-t1x9gknd 691 2 of of IN cord-010119-t1x9gknd 691 3 Red Red NNP cord-010119-t1x9gknd 691 4 Blood Blood NNP cord-010119-t1x9gknd 691 5 Cell Cell NNP cord-010119-t1x9gknd 691 6 Antibodies Antibodies NNPS cord-010119-t1x9gknd 691 7 in in IN cord-010119-t1x9gknd 691 8 Human Human NNP cord-010119-t1x9gknd 691 9 Breast Breast NNP cord-010119-t1x9gknd 691 10 Milk Milk NNP cord-010119-t1x9gknd 691 11 By by IN cord-010119-t1x9gknd 691 12 Novel Novel NNP cord-010119-t1x9gknd 691 13 Adaptation Adaptation NNP cord-010119-t1x9gknd 691 14 of of IN cord-010119-t1x9gknd 691 15 Serological Serological NNP cord-010119-t1x9gknd 691 16 Method Method NNP cord-010119-t1x9gknd 692 1 Philippe Philippe NNP cord-010119-t1x9gknd 692 2 P P NNP cord-010119-t1x9gknd 692 3 Pary Pary NNP cord-010119-t1x9gknd 692 4 * * NFP cord-010119-t1x9gknd 692 5 , , , cord-010119-t1x9gknd 692 6 Alexis Alexis NNP cord-010119-t1x9gknd 692 7 Leonard Leonard NNP cord-010119-t1x9gknd 692 8 , , , cord-010119-t1x9gknd 692 9 Lauren Lauren NNP cord-010119-t1x9gknd 692 10 Hittson Hittson NNP cord-010119-t1x9gknd 692 11 , , , cord-010119-t1x9gknd 692 12 Naomi Naomi NNP cord-010119-t1x9gknd 692 13 LC LC NNP cord-010119-t1x9gknd 692 14 Luban Luban NNP cord-010119-t1x9gknd 692 15 , , , cord-010119-t1x9gknd 692 16 Deepika Deepika NNP cord-010119-t1x9gknd 692 17 S S NNP cord-010119-t1x9gknd 692 18 Darbari Darbari NNP cord-010119-t1x9gknd 692 19 , , , cord-010119-t1x9gknd 692 20 Yunchuan Yunchuan NNP cord-010119-t1x9gknd 692 21 Delores Delores NNP cord-010119-t1x9gknd 692 22 Mo Mo NNP cord-010119-t1x9gknd 692 23 , , , cord-010119-t1x9gknd 692 24 Cyril Cyril NNP cord-010119-t1x9gknd 692 25 Jacquot Jacquot NNP cord-010119-t1x9gknd 692 26 , , , cord-010119-t1x9gknd 692 27 Valli Valli NNP cord-010119-t1x9gknd 692 28 Criss Criss NNP cord-010119-t1x9gknd 692 29 and and CC cord-010119-t1x9gknd 692 30 Jennifer Jennifer NNP cord-010119-t1x9gknd 692 31 Webb Webb NNP cord-010119-t1x9gknd 692 32 . . . cord-010119-t1x9gknd 693 1 Children child NNS cord-010119-t1x9gknd 693 2 's 's POS cord-010119-t1x9gknd 693 3 National National NNP cord-010119-t1x9gknd 693 4 Medical Medical NNP cord-010119-t1x9gknd 693 5 Center Center NNP cord-010119-t1x9gknd 693 6 Background Background NNP cord-010119-t1x9gknd 693 7 / / SYM cord-010119-t1x9gknd 693 8 Case Case NNP cord-010119-t1x9gknd 693 9 Studies Studies NNPS cord-010119-t1x9gknd 694 1 : : : cord-010119-t1x9gknd 694 2 Human human JJ cord-010119-t1x9gknd 694 3 breast breast NN cord-010119-t1x9gknd 694 4 milk milk NN cord-010119-t1x9gknd 694 5 contains contain VBZ cord-010119-t1x9gknd 694 6 immunoglobulins immunoglobulin NNS cord-010119-t1x9gknd 694 7 that that WDT cord-010119-t1x9gknd 694 8 are be VBP cord-010119-t1x9gknd 694 9 present present JJ cord-010119-t1x9gknd 694 10 in in IN cord-010119-t1x9gknd 694 11 maternal maternal JJ cord-010119-t1x9gknd 694 12 serum serum NN cord-010119-t1x9gknd 694 13 and and CC cord-010119-t1x9gknd 694 14 secretions secretion NNS cord-010119-t1x9gknd 694 15 . . . cord-010119-t1x9gknd 695 1 Data datum NNS cord-010119-t1x9gknd 695 2 in in IN cord-010119-t1x9gknd 695 3 mice mouse NNS cord-010119-t1x9gknd 695 4 has have VBZ cord-010119-t1x9gknd 695 5 demonstrated demonstrate VBN cord-010119-t1x9gknd 695 6 the the DT cord-010119-t1x9gknd 695 7 potential potential NN cord-010119-t1x9gknd 695 8 for for IN cord-010119-t1x9gknd 695 9 Kell Kell NNP cord-010119-t1x9gknd 695 10 antibodies antibody NNS cord-010119-t1x9gknd 695 11 to to TO cord-010119-t1x9gknd 695 12 be be VB cord-010119-t1x9gknd 695 13 absorbed absorb VBN cord-010119-t1x9gknd 695 14 enterally enterally RB cord-010119-t1x9gknd 695 15 from from IN cord-010119-t1x9gknd 695 16 breast breast NN cord-010119-t1x9gknd 695 17 milk milk NN cord-010119-t1x9gknd 695 18 and and CC cord-010119-t1x9gknd 695 19 impact impact VB cord-010119-t1x9gknd 695 20 the the DT cord-010119-t1x9gknd 695 21 survival survival NN cord-010119-t1x9gknd 695 22 of of IN cord-010119-t1x9gknd 695 23 transfused transfuse VBN cord-010119-t1x9gknd 695 24 Kell Kell NNP cord-010119-t1x9gknd 695 25 positive positive JJ cord-010119-t1x9gknd 695 26 cells cell NNS cord-010119-t1x9gknd 695 27 ; ; : cord-010119-t1x9gknd 695 28 however however RB cord-010119-t1x9gknd 695 29 , , , cord-010119-t1x9gknd 695 30 methods method NNS cord-010119-t1x9gknd 695 31 to to TO cord-010119-t1x9gknd 695 32 test test VB cord-010119-t1x9gknd 695 33 and and CC cord-010119-t1x9gknd 695 34 titer titer VB cord-010119-t1x9gknd 695 35 human human JJ cord-010119-t1x9gknd 695 36 breast breast NN cord-010119-t1x9gknd 695 37 milk milk NN cord-010119-t1x9gknd 695 38 for for IN cord-010119-t1x9gknd 695 39 red red JJ cord-010119-t1x9gknd 695 40 cell cell NN cord-010119-t1x9gknd 695 41 antibodies antibody NNS cord-010119-t1x9gknd 695 42 are be VBP cord-010119-t1x9gknd 695 43 lacking lack VBG cord-010119-t1x9gknd 695 44 . . . cord-010119-t1x9gknd 696 1 A a DT cord-010119-t1x9gknd 696 2 two two CD cord-010119-t1x9gknd 696 3 week week NN cord-010119-t1x9gknd 696 4 old old JJ cord-010119-t1x9gknd 696 5 infant infant NN cord-010119-t1x9gknd 696 6 with with IN cord-010119-t1x9gknd 696 7 a a DT cord-010119-t1x9gknd 696 8 history history NN cord-010119-t1x9gknd 696 9 of of IN cord-010119-t1x9gknd 696 10 Rh Rh NNP cord-010119-t1x9gknd 696 11 - - HYPH cord-010119-t1x9gknd 696 12 D d JJ cord-010119-t1x9gknd 696 13 hemolytic hemolytic JJ cord-010119-t1x9gknd 696 14 disease disease NN cord-010119-t1x9gknd 696 15 of of IN cord-010119-t1x9gknd 696 16 the the DT cord-010119-t1x9gknd 696 17 fetus fetus NN cord-010119-t1x9gknd 696 18 and and CC cord-010119-t1x9gknd 696 19 newborn newborn JJ cord-010119-t1x9gknd 696 20 ( ( -LRB- cord-010119-t1x9gknd 696 21 HDFN HDFN NNP cord-010119-t1x9gknd 696 22 ) ) -RRB- cord-010119-t1x9gknd 696 23 , , , cord-010119-t1x9gknd 696 24 previously previously RB cord-010119-t1x9gknd 696 25 treated treat VBN cord-010119-t1x9gknd 696 26 with with IN cord-010119-t1x9gknd 696 27 Intravenous Intravenous NNP cord-010119-t1x9gknd 696 28 Immunoglobulin Immunoglobulin NNP cord-010119-t1x9gknd 696 29 and and CC cord-010119-t1x9gknd 696 30 phototherapy phototherapy NN cord-010119-t1x9gknd 696 31 , , , cord-010119-t1x9gknd 696 32 was be VBD cord-010119-t1x9gknd 696 33 referred refer VBN cord-010119-t1x9gknd 696 34 for for IN cord-010119-t1x9gknd 696 35 anemia anemia NN cord-010119-t1x9gknd 696 36 and and CC cord-010119-t1x9gknd 696 37 reticulocytosis reticulocytosis NN cord-010119-t1x9gknd 696 38 . . . cord-010119-t1x9gknd 697 1 Patient Patient NNP cord-010119-t1x9gknd 697 2 was be VBD cord-010119-t1x9gknd 697 3 O o UH cord-010119-t1x9gknd 697 4 positive positive JJ cord-010119-t1x9gknd 697 5 , , , cord-010119-t1x9gknd 697 6 positive positive JJ cord-010119-t1x9gknd 697 7 Direct direct JJ cord-010119-t1x9gknd 697 8 Antiglobulin Antiglobulin NNP cord-010119-t1x9gknd 697 9 Test test NN cord-010119-t1x9gknd 697 10 ( ( -LRB- cord-010119-t1x9gknd 697 11 DAT DAT NNP cord-010119-t1x9gknd 697 12 ) ) -RRB- cord-010119-t1x9gknd 697 13 41 41 CD cord-010119-t1x9gknd 697 14 with with IN cord-010119-t1x9gknd 697 15 anti anti JJ cord-010119-t1x9gknd 697 16 - - JJ cord-010119-t1x9gknd 697 17 human human JJ cord-010119-t1x9gknd 697 18 IgG igg NN cord-010119-t1x9gknd 697 19 only only RB cord-010119-t1x9gknd 697 20 , , , cord-010119-t1x9gknd 697 21 and and CC cord-010119-t1x9gknd 697 22 a a DT cord-010119-t1x9gknd 697 23 31 31 CD cord-010119-t1x9gknd 697 24 positive positive JJ cord-010119-t1x9gknd 697 25 antibody antibody NN cord-010119-t1x9gknd 697 26 screen screen NN cord-010119-t1x9gknd 697 27 by by IN cord-010119-t1x9gknd 697 28 gel gel NN cord-010119-t1x9gknd 697 29 method method NN cord-010119-t1x9gknd 697 30 . . . cord-010119-t1x9gknd 698 1 Antibody antibody NN cord-010119-t1x9gknd 698 2 identification identification NN cord-010119-t1x9gknd 698 3 showed show VBD cord-010119-t1x9gknd 698 4 anti anti JJ cord-010119-t1x9gknd 698 5 - - JJ cord-010119-t1x9gknd 698 6 D d JJ cord-010119-t1x9gknd 698 7 in in IN cord-010119-t1x9gknd 698 8 both both CC cord-010119-t1x9gknd 698 9 the the DT cord-010119-t1x9gknd 698 10 plasma plasma NN cord-010119-t1x9gknd 698 11 and and CC cord-010119-t1x9gknd 698 12 eluate eluate NN cord-010119-t1x9gknd 698 13 . . . cord-010119-t1x9gknd 699 1 Patient Patient NNP cord-010119-t1x9gknd 699 2 was be VBD cord-010119-t1x9gknd 699 3 transfused transfuse VBN cord-010119-t1x9gknd 699 4 O O NNP cord-010119-t1x9gknd 699 5 negative negative JJ cord-010119-t1x9gknd 699 6 red red JJ cord-010119-t1x9gknd 699 7 cells cell NNS cord-010119-t1x9gknd 699 8 and and CC cord-010119-t1x9gknd 699 9 discharged discharge VBN cord-010119-t1x9gknd 699 10 . . . cord-010119-t1x9gknd 700 1 Over over IN cord-010119-t1x9gknd 700 2 several several JJ cord-010119-t1x9gknd 700 3 weeks week NNS cord-010119-t1x9gknd 700 4 , , , cord-010119-t1x9gknd 700 5 the the DT cord-010119-t1x9gknd 700 6 patient patient NN cord-010119-t1x9gknd 700 7 returned return VBD cord-010119-t1x9gknd 700 8 twice twice RB cord-010119-t1x9gknd 700 9 for for IN cord-010119-t1x9gknd 700 10 persistent persistent JJ cord-010119-t1x9gknd 700 11 anemia anemia NN cord-010119-t1x9gknd 700 12 requiring require VBG cord-010119-t1x9gknd 700 13 additional additional JJ cord-010119-t1x9gknd 700 14 transfusions transfusion NNS cord-010119-t1x9gknd 700 15 . . . cord-010119-t1x9gknd 701 1 At at IN cord-010119-t1x9gknd 701 2 eight eight CD cord-010119-t1x9gknd 701 3 weeks week NNS cord-010119-t1x9gknd 701 4 of of IN cord-010119-t1x9gknd 701 5 age age NN cord-010119-t1x9gknd 701 6 , , , cord-010119-t1x9gknd 701 7 evaluation evaluation NN cord-010119-t1x9gknd 701 8 showed show VBD cord-010119-t1x9gknd 701 9 a a DT cord-010119-t1x9gknd 701 10 persistent persistent JJ cord-010119-t1x9gknd 701 11 DAT DAT NNP cord-010119-t1x9gknd 701 12 IgG igg NN cord-010119-t1x9gknd 701 13 reactivity reactivity NN cord-010119-t1x9gknd 701 14 concerning concern VBG cord-010119-t1x9gknd 701 15 for for IN cord-010119-t1x9gknd 701 16 continued continued JJ cord-010119-t1x9gknd 701 17 antibody antibody NN cord-010119-t1x9gknd 701 18 exposure exposure NN cord-010119-t1x9gknd 701 19 . . . cord-010119-t1x9gknd 702 1 Maternal maternal JJ cord-010119-t1x9gknd 702 2 breast breast NN cord-010119-t1x9gknd 702 3 milk milk NN cord-010119-t1x9gknd 702 4 was be VBD cord-010119-t1x9gknd 702 5 evaluated evaluate VBN cord-010119-t1x9gknd 702 6 as as IN cord-010119-t1x9gknd 702 7 a a DT cord-010119-t1x9gknd 702 8 potential potential JJ cord-010119-t1x9gknd 702 9 source source NN cord-010119-t1x9gknd 702 10 . . . cord-010119-t1x9gknd 703 1 Study Study NNP cord-010119-t1x9gknd 703 2 Design Design NNP cord-010119-t1x9gknd 703 3 / / SYM cord-010119-t1x9gknd 703 4 Method method NN cord-010119-t1x9gknd 703 5 : : : cord-010119-t1x9gknd 704 1 Based base VBN cord-010119-t1x9gknd 704 2 on on IN cord-010119-t1x9gknd 704 3 similar similar JJ cord-010119-t1x9gknd 704 4 properties property NNS cord-010119-t1x9gknd 704 5 of of IN cord-010119-t1x9gknd 704 6 human human JJ cord-010119-t1x9gknd 704 7 breast breast NN cord-010119-t1x9gknd 704 8 milk milk NN cord-010119-t1x9gknd 704 9 and and CC cord-010119-t1x9gknd 704 10 plasma plasma NN cord-010119-t1x9gknd 704 11 , , , cord-010119-t1x9gknd 704 12 testing testing NN cord-010119-t1x9gknd 704 13 to to TO cord-010119-t1x9gknd 704 14 identify identify VB cord-010119-t1x9gknd 704 15 IgG igg NN cord-010119-t1x9gknd 704 16 antibodies antibody NNS cord-010119-t1x9gknd 704 17 using use VBG cord-010119-t1x9gknd 704 18 a a DT cord-010119-t1x9gknd 704 19 stantard stantard NN cord-010119-t1x9gknd 704 20 tube tube NN cord-010119-t1x9gknd 704 21 saline saline NN cord-010119-t1x9gknd 704 22 method method NN cord-010119-t1x9gknd 704 23 was be VBD cord-010119-t1x9gknd 704 24 performed perform VBN cord-010119-t1x9gknd 704 25 with with IN cord-010119-t1x9gknd 704 26 a a DT cord-010119-t1x9gknd 704 27 60 60 CD cord-010119-t1x9gknd 704 28 minute minute NN cord-010119-t1x9gknd 704 29 378C 378c CD cord-010119-t1x9gknd 704 30 incubation incubation NN cord-010119-t1x9gknd 704 31 , , , cord-010119-t1x9gknd 704 32 followed follow VBN cord-010119-t1x9gknd 704 33 by by IN cord-010119-t1x9gknd 704 34 3 3 CD cord-010119-t1x9gknd 704 35 automated automate VBN cord-010119-t1x9gknd 704 36 washes wash NNS cord-010119-t1x9gknd 704 37 prior prior RB cord-010119-t1x9gknd 704 38 to to IN cord-010119-t1x9gknd 704 39 the the DT cord-010119-t1x9gknd 704 40 addition addition NN cord-010119-t1x9gknd 704 41 of of IN cord-010119-t1x9gknd 704 42 anti anti JJ cord-010119-t1x9gknd 704 43 - - JJ cord-010119-t1x9gknd 704 44 human human JJ cord-010119-t1x9gknd 704 45 IgG igg NN cord-010119-t1x9gknd 704 46 reagent reagent NN cord-010119-t1x9gknd 704 47 . . . cord-010119-t1x9gknd 705 1 As as IN cord-010119-t1x9gknd 705 2 a a DT cord-010119-t1x9gknd 705 3 control control NN cord-010119-t1x9gknd 705 4 , , , cord-010119-t1x9gknd 705 5 breast breast NN cord-010119-t1x9gknd 705 6 milk milk NN cord-010119-t1x9gknd 705 7 from from IN cord-010119-t1x9gknd 705 8 an an DT cord-010119-t1x9gknd 705 9 O o UH cord-010119-t1x9gknd 705 10 positive positive JJ cord-010119-t1x9gknd 705 11 , , , cord-010119-t1x9gknd 705 12 antibody antibody NN cord-010119-t1x9gknd 705 13 screen screen NN cord-010119-t1x9gknd 705 14 negative negative JJ cord-010119-t1x9gknd 705 15 mother mother NN cord-010119-t1x9gknd 705 16 was be VBD cord-010119-t1x9gknd 705 17 used use VBN cord-010119-t1x9gknd 705 18 to to TO cord-010119-t1x9gknd 705 19 assess assess VB cord-010119-t1x9gknd 705 20 for for IN cord-010119-t1x9gknd 705 21 interference interference NN cord-010119-t1x9gknd 705 22 by by IN cord-010119-t1x9gknd 705 23 milk milk NN cord-010119-t1x9gknd 705 24 proteins protein NNS cord-010119-t1x9gknd 705 25 . . . cord-010119-t1x9gknd 706 1 Antibody antibody NN cord-010119-t1x9gknd 706 2 screens screen NNS cord-010119-t1x9gknd 706 3 were be VBD cord-010119-t1x9gknd 706 4 performed perform VBN cord-010119-t1x9gknd 706 5 on on IN cord-010119-t1x9gknd 706 6 the the DT cord-010119-t1x9gknd 706 7 plasma plasma NN cord-010119-t1x9gknd 706 8 of of IN cord-010119-t1x9gknd 706 9 the the DT cord-010119-t1x9gknd 706 10 patient patient NN cord-010119-t1x9gknd 706 11 , , , cord-010119-t1x9gknd 706 12 the the DT cord-010119-t1x9gknd 706 13 patient patient NN cord-010119-t1x9gknd 706 14 's 's POS cord-010119-t1x9gknd 706 15 mother mother NN cord-010119-t1x9gknd 706 16 and and CC cord-010119-t1x9gknd 706 17 the the DT cord-010119-t1x9gknd 706 18 control control NN cord-010119-t1x9gknd 706 19 concurrently concurrently RB cord-010119-t1x9gknd 706 20 using use VBG cord-010119-t1x9gknd 706 21 the the DT cord-010119-t1x9gknd 706 22 same same JJ cord-010119-t1x9gknd 706 23 method method NN cord-010119-t1x9gknd 706 24 . . . cord-010119-t1x9gknd 707 1 Antibody antibody NN cord-010119-t1x9gknd 707 2 identification identification NN cord-010119-t1x9gknd 707 3 and and CC cord-010119-t1x9gknd 707 4 titers titer NNS cord-010119-t1x9gknd 707 5 were be VBD cord-010119-t1x9gknd 707 6 also also RB cord-010119-t1x9gknd 707 7 performed perform VBN cord-010119-t1x9gknd 707 8 when when WRB cord-010119-t1x9gknd 707 9 indicated indicate VBN cord-010119-t1x9gknd 707 10 . . . cord-010119-t1x9gknd 708 1 Only only RB cord-010119-t1x9gknd 708 2 freshly freshly RB cord-010119-t1x9gknd 708 3 collected collect VBD cord-010119-t1x9gknd 708 4 breast breast NN cord-010119-t1x9gknd 708 5 milk milk NN cord-010119-t1x9gknd 708 6 stored store VBN cord-010119-t1x9gknd 708 7 at at IN cord-010119-t1x9gknd 708 8 room room NN cord-010119-t1x9gknd 708 9 temperature temperature NN cord-010119-t1x9gknd 708 10 for for IN cord-010119-t1x9gknd 708 11 less less JJR cord-010119-t1x9gknd 708 12 than than IN cord-010119-t1x9gknd 708 13 3 3 CD cord-010119-t1x9gknd 708 14 days day NNS cord-010119-t1x9gknd 708 15 was be VBD cord-010119-t1x9gknd 708 16 found find VBN cord-010119-t1x9gknd 708 17 suitable suitable JJ cord-010119-t1x9gknd 708 18 for for IN cord-010119-t1x9gknd 708 19 this this DT cord-010119-t1x9gknd 708 20 technique technique NN cord-010119-t1x9gknd 708 21 . . . cord-010119-t1x9gknd 709 1 Results result NNS cord-010119-t1x9gknd 709 2 / / SYM cord-010119-t1x9gknd 709 3 Finding finding NN cord-010119-t1x9gknd 709 4 : : : cord-010119-t1x9gknd 709 5 The the DT cord-010119-t1x9gknd 709 6 patient patient NN cord-010119-t1x9gknd 709 7 's 's POS cord-010119-t1x9gknd 709 8 mother mother NN cord-010119-t1x9gknd 709 9 showed show VBD cord-010119-t1x9gknd 709 10 plasma plasma NN cord-010119-t1x9gknd 709 11 anti anti JJ cord-010119-t1x9gknd 709 12 - - JJ cord-010119-t1x9gknd 709 13 D d JJ cord-010119-t1x9gknd 709 14 with with IN cord-010119-t1x9gknd 709 15 a a DT cord-010119-t1x9gknd 709 16 titer titer NN cord-010119-t1x9gknd 709 17 4096 4096 CD cord-010119-t1x9gknd 709 18 and and CC cord-010119-t1x9gknd 709 19 the the DT cord-010119-t1x9gknd 709 20 breast breast NN cord-010119-t1x9gknd 709 21 milk milk NN cord-010119-t1x9gknd 709 22 showed show VBD cord-010119-t1x9gknd 709 23 anti anti JJ cord-010119-t1x9gknd 709 24 - - JJ cord-010119-t1x9gknd 709 25 D d JJ cord-010119-t1x9gknd 709 26 with with IN cord-010119-t1x9gknd 709 27 a a DT cord-010119-t1x9gknd 709 28 titer titer NN cord-010119-t1x9gknd 709 29 between between IN cord-010119-t1x9gknd 709 30 16 16 CD cord-010119-t1x9gknd 709 31 and and CC cord-010119-t1x9gknd 709 32 64 64 CD cord-010119-t1x9gknd 709 33 . . . cord-010119-t1x9gknd 710 1 The the DT cord-010119-t1x9gknd 710 2 patient patient NN cord-010119-t1x9gknd 710 3 had have VBD cord-010119-t1x9gknd 710 4 a a DT cord-010119-t1x9gknd 710 5 consistent consistent JJ cord-010119-t1x9gknd 710 6 plasma plasma NN cord-010119-t1x9gknd 710 7 anti anti JJ cord-010119-t1x9gknd 710 8 - - JJ cord-010119-t1x9gknd 710 9 D d JJ cord-010119-t1x9gknd 710 10 titer titer NN cord-010119-t1x9gknd 710 11 of of IN cord-010119-t1x9gknd 710 12 8 8 CD cord-010119-t1x9gknd 710 13 . . . cord-010119-t1x9gknd 711 1 The the DT cord-010119-t1x9gknd 711 2 patient patient NN cord-010119-t1x9gknd 711 3 's 's POS cord-010119-t1x9gknd 711 4 mother mother NN cord-010119-t1x9gknd 711 5 chose choose VBD cord-010119-t1x9gknd 711 6 to to TO cord-010119-t1x9gknd 711 7 stop stop VB cord-010119-t1x9gknd 711 8 breast breast NN cord-010119-t1x9gknd 711 9 feeding feeding NN cord-010119-t1x9gknd 711 10 after after IN cord-010119-t1x9gknd 711 11 8 8 CD cord-010119-t1x9gknd 711 12 weeks week NNS cord-010119-t1x9gknd 711 13 , , , cord-010119-t1x9gknd 711 14 and and CC cord-010119-t1x9gknd 711 15 the the DT cord-010119-t1x9gknd 711 16 patient patient NN cord-010119-t1x9gknd 711 17 's 's POS cord-010119-t1x9gknd 711 18 hemoglobin hemoglobin NN cord-010119-t1x9gknd 711 19 was be VBD cord-010119-t1x9gknd 711 20 improved improve VBN cord-010119-t1x9gknd 711 21 at at IN cord-010119-t1x9gknd 711 22 12 12 CD cord-010119-t1x9gknd 711 23 and and CC cord-010119-t1x9gknd 711 24 16 16 CD cord-010119-t1x9gknd 711 25 weeks week NNS cord-010119-t1x9gknd 711 26 of of IN cord-010119-t1x9gknd 711 27 age age NN cord-010119-t1x9gknd 711 28 . . . cord-010119-t1x9gknd 712 1 Using use VBG cord-010119-t1x9gknd 712 2 this this DT cord-010119-t1x9gknd 712 3 method method NN cord-010119-t1x9gknd 712 4 , , , cord-010119-t1x9gknd 712 5 we -PRON- PRP cord-010119-t1x9gknd 712 6 identified identify VBD cord-010119-t1x9gknd 712 7 two two CD cord-010119-t1x9gknd 712 8 additional additional JJ cord-010119-t1x9gknd 712 9 cases case NNS cord-010119-t1x9gknd 712 10 of of IN cord-010119-t1x9gknd 712 11 breast breast NN cord-010119-t1x9gknd 712 12 milk milk NN cord-010119-t1x9gknd 712 13 induced induce VBN cord-010119-t1x9gknd 712 14 hemolysis hemolysis NN cord-010119-t1x9gknd 712 15 : : : cord-010119-t1x9gknd 712 16 another another DT cord-010119-t1x9gknd 712 17 anti anti JJ cord-010119-t1x9gknd 712 18 - - JJ cord-010119-t1x9gknd 712 19 D d JJ cord-010119-t1x9gknd 712 20 and and CC cord-010119-t1x9gknd 712 21 an an DT cord-010119-t1x9gknd 712 22 anti anti JJ cord-010119-t1x9gknd 712 23 - - NN cord-010119-t1x9gknd 712 24 Jka Jka NNP cord-010119-t1x9gknd 712 25 . . . cord-010119-t1x9gknd 713 1 Conclusion conclusion NN cord-010119-t1x9gknd 713 2 : : : cord-010119-t1x9gknd 714 1 Testing testing NN cord-010119-t1x9gknd 714 2 showed show VBD cord-010119-t1x9gknd 714 3 that that IN cord-010119-t1x9gknd 714 4 it -PRON- PRP cord-010119-t1x9gknd 714 5 is be VBZ cord-010119-t1x9gknd 714 6 possible possible JJ cord-010119-t1x9gknd 714 7 to to TO cord-010119-t1x9gknd 714 8 identify identify VB cord-010119-t1x9gknd 714 9 red red JJ cord-010119-t1x9gknd 714 10 cell cell NN cord-010119-t1x9gknd 714 11 IgG IgG NNP cord-010119-t1x9gknd 714 12 antibodies antibody NNS cord-010119-t1x9gknd 714 13 in in IN cord-010119-t1x9gknd 714 14 human human JJ cord-010119-t1x9gknd 714 15 breast breast NN cord-010119-t1x9gknd 714 16 milk milk NN cord-010119-t1x9gknd 714 17 using use VBG cord-010119-t1x9gknd 714 18 a a DT cord-010119-t1x9gknd 714 19 standard standard JJ cord-010119-t1x9gknd 714 20 tube tube NN cord-010119-t1x9gknd 714 21 saline saline NN cord-010119-t1x9gknd 714 22 method method NN cord-010119-t1x9gknd 714 23 . . . cord-010119-t1x9gknd 715 1 We -PRON- PRP cord-010119-t1x9gknd 715 2 identified identify VBD cord-010119-t1x9gknd 715 3 implicated implicate VBN cord-010119-t1x9gknd 715 4 antibodies antibody NNS cord-010119-t1x9gknd 715 5 in in IN cord-010119-t1x9gknd 715 6 the the DT cord-010119-t1x9gknd 715 7 breast breast NN cord-010119-t1x9gknd 715 8 milk milk NN cord-010119-t1x9gknd 715 9 received receive VBN cord-010119-t1x9gknd 715 10 by by IN cord-010119-t1x9gknd 715 11 infants infant NNS cord-010119-t1x9gknd 715 12 with with IN cord-010119-t1x9gknd 715 13 persistent persistent JJ cord-010119-t1x9gknd 715 14 anemia anemia NN cord-010119-t1x9gknd 715 15 due due IN cord-010119-t1x9gknd 715 16 to to IN cord-010119-t1x9gknd 715 17 HDFN HDFN NNP cord-010119-t1x9gknd 715 18 . . . cord-010119-t1x9gknd 716 1 Breast breast NN cord-010119-t1x9gknd 716 2 milk milk NN cord-010119-t1x9gknd 716 3 titers titer NNS cord-010119-t1x9gknd 716 4 were be VBD cord-010119-t1x9gknd 716 5 generally generally RB cord-010119-t1x9gknd 716 6 lower low JJR cord-010119-t1x9gknd 716 7 than than IN cord-010119-t1x9gknd 716 8 maternal maternal JJ cord-010119-t1x9gknd 716 9 serum serum NN cord-010119-t1x9gknd 716 10 titers titer NNS cord-010119-t1x9gknd 716 11 , , , cord-010119-t1x9gknd 716 12 but but CC cord-010119-t1x9gknd 716 13 titers titer NNS cord-010119-t1x9gknd 716 14 varied varied JJ cord-010119-t1x9gknd 716 15 depending depend VBG cord-010119-t1x9gknd 716 16 upon upon IN cord-010119-t1x9gknd 716 17 the the DT cord-010119-t1x9gknd 716 18 timing timing NN cord-010119-t1x9gknd 716 19 and and CC cord-010119-t1x9gknd 716 20 frequency frequency NN cord-010119-t1x9gknd 716 21 of of IN cord-010119-t1x9gknd 716 22 breast breast NN cord-010119-t1x9gknd 716 23 feeding feeding NN cord-010119-t1x9gknd 716 24 . . . cord-010119-t1x9gknd 717 1 Cessation cessation NN cord-010119-t1x9gknd 717 2 of of IN cord-010119-t1x9gknd 717 3 breast breast NN cord-010119-t1x9gknd 717 4 feeding feeding NN cord-010119-t1x9gknd 717 5 correlated correlate VBN cord-010119-t1x9gknd 717 6 with with IN cord-010119-t1x9gknd 717 7 improved improve VBN cord-010119-t1x9gknd 717 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 717 9 in in IN cord-010119-t1x9gknd 717 10 affected affect VBN cord-010119-t1x9gknd 717 11 infants infant NNS cord-010119-t1x9gknd 717 12 . . . cord-010119-t1x9gknd 718 1 Background Background NNP cord-010119-t1x9gknd 718 2 / / SYM cord-010119-t1x9gknd 718 3 Case Case NNP cord-010119-t1x9gknd 718 4 Studies Studies NNPS cord-010119-t1x9gknd 718 5 : : : cord-010119-t1x9gknd 719 1 Red red JJ cord-010119-t1x9gknd 719 2 blood blood NN cord-010119-t1x9gknd 719 3 cell cell NN cord-010119-t1x9gknd 719 4 ( ( -LRB- cord-010119-t1x9gknd 719 5 RBC RBC NNP cord-010119-t1x9gknd 719 6 ) ) -RRB- cord-010119-t1x9gknd 719 7 transfusion transfusion NN cord-010119-t1x9gknd 719 8 is be VBZ cord-010119-t1x9gknd 719 9 lifesaving lifesave VBG cord-010119-t1x9gknd 719 10 for for IN cord-010119-t1x9gknd 719 11 patients patient NNS cord-010119-t1x9gknd 719 12 with with IN cord-010119-t1x9gknd 719 13 sickle sickle NN cord-010119-t1x9gknd 719 14 cell cell NN cord-010119-t1x9gknd 719 15 disease disease NN cord-010119-t1x9gknd 719 16 ( ( -LRB- cord-010119-t1x9gknd 719 17 SCD SCD NNP cord-010119-t1x9gknd 719 18 ) ) -RRB- cord-010119-t1x9gknd 719 19 , , , cord-010119-t1x9gknd 719 20 but but CC cord-010119-t1x9gknd 719 21 is be VBZ cord-010119-t1x9gknd 719 22 commonly commonly RB cord-010119-t1x9gknd 719 23 complicated complicate VBN cord-010119-t1x9gknd 719 24 by by IN cord-010119-t1x9gknd 719 25 RBC RBC NNP cord-010119-t1x9gknd 719 26 alloimmunization alloimmunization NN cord-010119-t1x9gknd 719 27 . . . cord-010119-t1x9gknd 720 1 Despite despite IN cord-010119-t1x9gknd 720 2 transfusion transfusion NN cord-010119-t1x9gknd 720 3 protocols protocol NNS cord-010119-t1x9gknd 720 4 serologically serologically RB cord-010119-t1x9gknd 720 5 matching match VBG cord-010119-t1x9gknd 720 6 for for IN cord-010119-t1x9gknd 720 7 C c NN cord-010119-t1x9gknd 720 8 , , , cord-010119-t1x9gknd 720 9 E E NNP cord-010119-t1x9gknd 720 10 , , , cord-010119-t1x9gknd 720 11 and and CC cord-010119-t1x9gknd 720 12 Kell Kell NNP cord-010119-t1x9gknd 720 13 antigens antigen NNS cord-010119-t1x9gknd 720 14 , , , cord-010119-t1x9gknd 720 15 alloimmunization alloimmunization VBN cord-010119-t1x9gknd 720 16 to to IN cord-010119-t1x9gknd 720 17 Rh Rh NNP cord-010119-t1x9gknd 720 18 antigens antigen NNS cord-010119-t1x9gknd 720 19 continues continue VBZ cord-010119-t1x9gknd 720 20 . . . cord-010119-t1x9gknd 721 1 SCD SCD NNP cord-010119-t1x9gknd 721 2 patients patient NNS cord-010119-t1x9gknd 721 3 often often RB cord-010119-t1x9gknd 721 4 exhibit exhibit VBP cord-010119-t1x9gknd 721 5 a a DT cord-010119-t1x9gknd 721 6 hybrid hybrid JJ cord-010119-t1x9gknd 721 7 RHD RHD NNP cord-010119-t1x9gknd 721 8 - - HYPH cord-010119-t1x9gknd 721 9 CE CE NNP cord-010119-t1x9gknd 721 10 - - HYPH cord-010119-t1x9gknd 721 11 D d NN cord-010119-t1x9gknd 721 12 gene gene NN cord-010119-t1x9gknd 721 13 which which WDT cord-010119-t1x9gknd 721 14 is be VBZ cord-010119-t1x9gknd 721 15 often often RB cord-010119-t1x9gknd 721 16 characterized characterize VBN cord-010119-t1x9gknd 721 17 by by IN cord-010119-t1x9gknd 721 18 the the DT cord-010119-t1x9gknd 721 19 production production NN cord-010119-t1x9gknd 721 20 of of IN cord-010119-t1x9gknd 721 21 a a DT cord-010119-t1x9gknd 721 22 partial partial JJ cord-010119-t1x9gknd 721 23 C c NN cord-010119-t1x9gknd 721 24 antigen antigen NN cord-010119-t1x9gknd 721 25 . . . cord-010119-t1x9gknd 722 1 It -PRON- PRP cord-010119-t1x9gknd 722 2 has have VBZ cord-010119-t1x9gknd 722 3 been be VBN cord-010119-t1x9gknd 722 4 previously previously RB cord-010119-t1x9gknd 722 5 documented document VBN cord-010119-t1x9gknd 722 6 that that IN cord-010119-t1x9gknd 722 7 30 30 CD cord-010119-t1x9gknd 722 8 % % NN cord-010119-t1x9gknd 722 9 of of IN cord-010119-t1x9gknd 722 10 C1 C1 NNP cord-010119-t1x9gknd 722 11 SCD SCD NNP cord-010119-t1x9gknd 722 12 patients patient NNS cord-010119-t1x9gknd 722 13 from from IN cord-010119-t1x9gknd 722 14 the the DT cord-010119-t1x9gknd 722 15 West West NNP cord-010119-t1x9gknd 722 16 Indies Indies NNPS cord-010119-t1x9gknd 722 17 and and CC cord-010119-t1x9gknd 722 18 West West NNP cord-010119-t1x9gknd 722 19 and and CC cord-010119-t1x9gknd 722 20 Central Central NNP cord-010119-t1x9gknd 722 21 Africa Africa NNP cord-010119-t1x9gknd 722 22 are be VBP cord-010119-t1x9gknd 722 23 partial partial JJ cord-010119-t1x9gknd 722 24 C c NN cord-010119-t1x9gknd 722 25 and and CC cord-010119-t1x9gknd 722 26 at at IN cord-010119-t1x9gknd 722 27 ( ( -LRB- cord-010119-t1x9gknd 722 28 30 30 CD cord-010119-t1x9gknd 722 29 % % NN cord-010119-t1x9gknd 722 30 ) ) -RRB- cord-010119-t1x9gknd 722 31 risk risk NN cord-010119-t1x9gknd 722 32 for for IN cord-010119-t1x9gknd 722 33 alloimmunization alloimmunization NN cord-010119-t1x9gknd 722 34 to to IN cord-010119-t1x9gknd 722 35 the the DT cord-010119-t1x9gknd 722 36 C C NNP cord-010119-t1x9gknd 722 37 antigen antigen NN cord-010119-t1x9gknd 722 38 through through IN cord-010119-t1x9gknd 722 39 transfusion transfusion NN cord-010119-t1x9gknd 722 40 of of IN cord-010119-t1x9gknd 722 41 C1 C1 NNP cord-010119-t1x9gknd 722 42 RBCs rbc NNS cord-010119-t1x9gknd 722 43 . . . cord-010119-t1x9gknd 723 1 This this DT cord-010119-t1x9gknd 723 2 study study NN cord-010119-t1x9gknd 723 3 sought seek VBD cord-010119-t1x9gknd 723 4 to to TO cord-010119-t1x9gknd 723 5 determine determine VB cord-010119-t1x9gknd 723 6 the the DT cord-010119-t1x9gknd 723 7 prevalence prevalence NN cord-010119-t1x9gknd 723 8 within within IN cord-010119-t1x9gknd 723 9 a a DT cord-010119-t1x9gknd 723 10 cohort cohort NN cord-010119-t1x9gknd 723 11 of of IN cord-010119-t1x9gknd 723 12 children child NNS cord-010119-t1x9gknd 723 13 with with IN cord-010119-t1x9gknd 723 14 SCD SCD NNP cord-010119-t1x9gknd 723 15 at at IN cord-010119-t1x9gknd 723 16 a a DT cord-010119-t1x9gknd 723 17 U.S U.S NNP cord-010119-t1x9gknd 723 18 comprehensive comprehensive JJ cord-010119-t1x9gknd 723 19 SCD SCD NNP cord-010119-t1x9gknd 723 20 center center NN cord-010119-t1x9gknd 723 21 . . . cord-010119-t1x9gknd 724 1 Study Study NNP cord-010119-t1x9gknd 724 2 Design Design NNP cord-010119-t1x9gknd 724 3 / / SYM cord-010119-t1x9gknd 724 4 Method method NN cord-010119-t1x9gknd 724 5 : : : cord-010119-t1x9gknd 724 6 RBC RBC NNP cord-010119-t1x9gknd 724 7 genotyping genotyping NN cord-010119-t1x9gknd 724 8 results result NNS cord-010119-t1x9gknd 724 9 performed perform VBN cord-010119-t1x9gknd 724 10 on on IN cord-010119-t1x9gknd 724 11 all all DT cord-010119-t1x9gknd 724 12 SCD SCD NNP cord-010119-t1x9gknd 724 13 patients patient NNS cord-010119-t1x9gknd 724 14 using use VBG cord-010119-t1x9gknd 724 15 PreciseType PreciseType NNP cord-010119-t1x9gknd 724 16 HEA HEA NNP cord-010119-t1x9gknd 724 17 array array NN cord-010119-t1x9gknd 724 18 ( ( -LRB- cord-010119-t1x9gknd 724 19 Immucor Immucor NNP cord-010119-t1x9gknd 724 20 , , , cord-010119-t1x9gknd 724 21 Norcross Norcross NNP cord-010119-t1x9gknd 724 22 , , , cord-010119-t1x9gknd 724 23 GA GA NNP cord-010119-t1x9gknd 724 24 ) ) -RRB- cord-010119-t1x9gknd 724 25 at at IN cord-010119-t1x9gknd 724 26 Children Children NNP cord-010119-t1x9gknd 724 27 's 's POS cord-010119-t1x9gknd 724 28 Healthcare Healthcare NNP cord-010119-t1x9gknd 724 29 of of IN cord-010119-t1x9gknd 724 30 Atlanta Atlanta NNP cord-010119-t1x9gknd 724 31 were be VBD cord-010119-t1x9gknd 724 32 reviewed review VBN cord-010119-t1x9gknd 724 33 and and CC cord-010119-t1x9gknd 724 34 compared compare VBN cord-010119-t1x9gknd 724 35 to to IN cord-010119-t1x9gknd 724 36 the the DT cord-010119-t1x9gknd 724 37 serologic serologic JJ cord-010119-t1x9gknd 724 38 type type NN cord-010119-t1x9gknd 724 39 for for IN cord-010119-t1x9gknd 724 40 Rh Rh NNP cord-010119-t1x9gknd 724 41 ( ( -LRB- cord-010119-t1x9gknd 724 42 C C NNP cord-010119-t1x9gknd 724 43 / / SYM cord-010119-t1x9gknd 724 44 c c NN cord-010119-t1x9gknd 724 45 , , , cord-010119-t1x9gknd 724 46 E E NNP cord-010119-t1x9gknd 724 47 / / SYM cord-010119-t1x9gknd 724 48 e e NN cord-010119-t1x9gknd 724 49 ) ) -RRB- cord-010119-t1x9gknd 724 50 antigens antigen NNS cord-010119-t1x9gknd 724 51 . . . cord-010119-t1x9gknd 725 1 The the DT cord-010119-t1x9gknd 725 2 prevalence prevalence NN cord-010119-t1x9gknd 725 3 of of IN cord-010119-t1x9gknd 725 4 C c NN cord-010119-t1x9gknd 725 5 - - HYPH cord-010119-t1x9gknd 725 6 antigen antigen NN cord-010119-t1x9gknd 725 7 positive positive JJ cord-010119-t1x9gknd 725 8 patients patient NNS cord-010119-t1x9gknd 725 9 ( ( -LRB- cord-010119-t1x9gknd 725 10 serologically serologically RB cord-010119-t1x9gknd 725 11 ) ) -RRB- cord-010119-t1x9gknd 725 12 was be VBD cord-010119-t1x9gknd 725 13 determined determine VBN cord-010119-t1x9gknd 725 14 overall overall RB cord-010119-t1x9gknd 725 15 , , , cord-010119-t1x9gknd 725 16 and and CC cord-010119-t1x9gknd 725 17 compared compare VBN cord-010119-t1x9gknd 725 18 to to IN cord-010119-t1x9gknd 725 19 the the DT cord-010119-t1x9gknd 725 20 prevalence prevalence NN cord-010119-t1x9gknd 725 21 partial partial JJ cord-010119-t1x9gknd 725 22 C c NN cord-010119-t1x9gknd 725 23 antigen antigen NN cord-010119-t1x9gknd 725 24 based base VBN cord-010119-t1x9gknd 725 25 on on IN cord-010119-t1x9gknd 725 26 the the DT cord-010119-t1x9gknd 725 27 detection detection NN cord-010119-t1x9gknd 725 28 of of IN cord-010119-t1x9gknd 725 29 the the DT cord-010119-t1x9gknd 725 30 RHCE*ce(733G,1006 RHCE*ce(733G,1006 NNP cord-010119-t1x9gknd 725 31 T T NNP cord-010119-t1x9gknd 725 32 ) ) -RRB- cord-010119-t1x9gknd 725 33 allele allele NN cord-010119-t1x9gknd 725 34 in in IN cord-010119-t1x9gknd 725 35 the the DT cord-010119-t1x9gknd 725 36 absence absence NN cord-010119-t1x9gknd 725 37 of of IN cord-010119-t1x9gknd 725 38 an an DT cord-010119-t1x9gknd 725 39 RHCE RHCE NNP cord-010119-t1x9gknd 725 40 gene gene NN cord-010119-t1x9gknd 725 41 encoding encode VBG cord-010119-t1x9gknd 725 42 a a DT cord-010119-t1x9gknd 725 43 conventional conventional JJ cord-010119-t1x9gknd 725 44 C c NN cord-010119-t1x9gknd 725 45 antigen antigen NN cord-010119-t1x9gknd 725 46 in in IN cord-010119-t1x9gknd 725 47 trans trans NNP cord-010119-t1x9gknd 725 48 , , , cord-010119-t1x9gknd 725 49 since since IN cord-010119-t1x9gknd 725 50 this this DT cord-010119-t1x9gknd 725 51 allele allele NN cord-010119-t1x9gknd 725 52 is be VBZ cord-010119-t1x9gknd 725 53 commonly commonly RB cord-010119-t1x9gknd 725 54 linked link VBN cord-010119-t1x9gknd 725 55 to to IN cord-010119-t1x9gknd 725 56 the the DT cord-010119-t1x9gknd 725 57 hybrid hybrid JJ cord-010119-t1x9gknd 725 58 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 725 59 - - HYPH cord-010119-t1x9gknd 725 60 CE(4 ce(4 NN cord-010119-t1x9gknd 725 61 - - HYPH cord-010119-t1x9gknd 725 62 7)-D 7)-d NN cord-010119-t1x9gknd 725 63 gene gene NN cord-010119-t1x9gknd 725 64 which which WDT cord-010119-t1x9gknd 725 65 encodes encode VBZ cord-010119-t1x9gknd 725 66 the the DT cord-010119-t1x9gknd 725 67 partial partial JJ cord-010119-t1x9gknd 725 68 C c NN cord-010119-t1x9gknd 725 69 antigen antigen NN cord-010119-t1x9gknd 725 70 . . . cord-010119-t1x9gknd 726 1 Review Review NNP cord-010119-t1x9gknd 726 2 of of IN cord-010119-t1x9gknd 726 3 the the DT cord-010119-t1x9gknd 726 4 blood blood NN cord-010119-t1x9gknd 726 5 bank bank NN cord-010119-t1x9gknd 726 6 information information NN cord-010119-t1x9gknd 726 7 system system NN cord-010119-t1x9gknd 726 8 was be VBD cord-010119-t1x9gknd 726 9 performed perform VBN cord-010119-t1x9gknd 726 10 to to TO cord-010119-t1x9gknd 726 11 identify identify VB cord-010119-t1x9gknd 726 12 the the DT cord-010119-t1x9gknd 726 13 number number NN cord-010119-t1x9gknd 726 14 of of IN cord-010119-t1x9gknd 726 15 C c NN cord-010119-t1x9gknd 726 16 - - HYPH cord-010119-t1x9gknd 726 17 antigen antigen NN cord-010119-t1x9gknd 726 18 positive positive JJ cord-010119-t1x9gknd 726 19 transfusion transfusion NN cord-010119-t1x9gknd 726 20 exposures exposure NNS cord-010119-t1x9gknd 726 21 and and CC cord-010119-t1x9gknd 726 22 frequency frequency NN cord-010119-t1x9gknd 726 23 of of IN cord-010119-t1x9gknd 726 24 alloimmunization alloimmunization NN cord-010119-t1x9gknd 726 25 to to IN cord-010119-t1x9gknd 726 26 the the DT cord-010119-t1x9gknd 726 27 C C NNP cord-010119-t1x9gknd 726 28 antigen antigen NN cord-010119-t1x9gknd 726 29 . . . cord-010119-t1x9gknd 727 1 Results result NNS cord-010119-t1x9gknd 727 2 / / SYM cord-010119-t1x9gknd 727 3 Finding finding NN cord-010119-t1x9gknd 727 4 : : : cord-010119-t1x9gknd 728 1 Out out IN cord-010119-t1x9gknd 728 2 of of IN cord-010119-t1x9gknd 728 3 a a DT cord-010119-t1x9gknd 728 4 total total NN cord-010119-t1x9gknd 728 5 of of IN cord-010119-t1x9gknd 728 6 255 255 CD cord-010119-t1x9gknd 728 7 patients patient NNS cord-010119-t1x9gknd 728 8 with with IN cord-010119-t1x9gknd 728 9 genotype genotype NN cord-010119-t1x9gknd 728 10 / / SYM cord-010119-t1x9gknd 728 11 Rh Rh NNP cord-010119-t1x9gknd 728 12 phenotype phenotype NN cord-010119-t1x9gknd 728 13 data datum NNS cord-010119-t1x9gknd 728 14 available available JJ cord-010119-t1x9gknd 728 15 , , , cord-010119-t1x9gknd 728 16 78 78 CD cord-010119-t1x9gknd 728 17 ( ( -LRB- cord-010119-t1x9gknd 728 18 30.6 30.6 CD cord-010119-t1x9gknd 728 19 % % NN cord-010119-t1x9gknd 728 20 ) ) -RRB- cord-010119-t1x9gknd 728 21 were be VBD cord-010119-t1x9gknd 728 22 C C NNP cord-010119-t1x9gknd 728 23 antigen antigen NN cord-010119-t1x9gknd 728 24 positive positive JJ cord-010119-t1x9gknd 728 25 serologically serologically RB cord-010119-t1x9gknd 728 26 . . . cord-010119-t1x9gknd 729 1 The the DT cord-010119-t1x9gknd 729 2 allele allele NN cord-010119-t1x9gknd 729 3 frequency frequency NN cord-010119-t1x9gknd 729 4 of of IN cord-010119-t1x9gknd 729 5 RHCE*ce(733G,1006 RHCE*ce(733G,1006 NNP cord-010119-t1x9gknd 729 6 T T NNP cord-010119-t1x9gknd 729 7 ) ) -RRB- cord-010119-t1x9gknd 729 8 was be VBD cord-010119-t1x9gknd 729 9 0.071 0.071 CD cord-010119-t1x9gknd 729 10 . . . cord-010119-t1x9gknd 730 1 In in IN cord-010119-t1x9gknd 730 2 total total NN cord-010119-t1x9gknd 730 3 , , , cord-010119-t1x9gknd 730 4 15 15 CD cord-010119-t1x9gknd 730 5 ( ( -LRB- cord-010119-t1x9gknd 730 6 5.9 5.9 CD cord-010119-t1x9gknd 730 7 % % NN cord-010119-t1x9gknd 730 8 ) ) -RRB- cord-010119-t1x9gknd 730 9 patients patient NNS cord-010119-t1x9gknd 730 10 possessed possess VBD cord-010119-t1x9gknd 730 11 RHCE*ce(733 RHCE*ce(733 NNP cord-010119-t1x9gknd 730 12 G G NNP cord-010119-t1x9gknd 730 13 , , , cord-010119-t1x9gknd 730 14 1006 1006 CD cord-010119-t1x9gknd 730 15 T T NNP cord-010119-t1x9gknd 730 16 ) ) -RRB- cord-010119-t1x9gknd 730 17 in in IN cord-010119-t1x9gknd 730 18 the the DT cord-010119-t1x9gknd 730 19 absence absence NN cord-010119-t1x9gknd 730 20 of of IN cord-010119-t1x9gknd 730 21 conventional conventional JJ cord-010119-t1x9gknd 730 22 C c NN cord-010119-t1x9gknd 730 23 gene gene NN cord-010119-t1x9gknd 730 24 in in IN cord-010119-t1x9gknd 730 25 trans trans NNP cord-010119-t1x9gknd 730 26 . . . cord-010119-t1x9gknd 731 1 Of of IN cord-010119-t1x9gknd 731 2 the the DT cord-010119-t1x9gknd 731 3 78 78 CD cord-010119-t1x9gknd 731 4 C c NN cord-010119-t1x9gknd 731 5 antigen antigen NN cord-010119-t1x9gknd 731 6 positive positive JJ cord-010119-t1x9gknd 731 7 patients patient NNS cord-010119-t1x9gknd 731 8 , , , cord-010119-t1x9gknd 731 9 15 15 CD cord-010119-t1x9gknd 731 10 individuals individual NNS cord-010119-t1x9gknd 731 11 ( ( -LRB- cord-010119-t1x9gknd 731 12 19.2 19.2 CD cord-010119-t1x9gknd 731 13 % % NN cord-010119-t1x9gknd 731 14 ) ) -RRB- cord-010119-t1x9gknd 731 15 were be VBD cord-010119-t1x9gknd 731 16 predicted predict VBN cord-010119-t1x9gknd 731 17 to to TO cord-010119-t1x9gknd 731 18 be be VB cord-010119-t1x9gknd 731 19 partial partial JJ cord-010119-t1x9gknd 731 20 C c NN cord-010119-t1x9gknd 731 21 based base VBN cord-010119-t1x9gknd 731 22 on on IN cord-010119-t1x9gknd 731 23 four four CD cord-010119-t1x9gknd 731 24 molecular molecular JJ cord-010119-t1x9gknd 731 25 profiles profile NNS cord-010119-t1x9gknd 731 26 [ [ -LRB- cord-010119-t1x9gknd 731 27 RHCE*ce(733 RHCE*ce(733 NNP cord-010119-t1x9gknd 731 28 G G NNP cord-010119-t1x9gknd 731 29 , , , cord-010119-t1x9gknd 731 30 1006T)/RHCE*ce:12 1006t)/rhce*ce:12 CD cord-010119-t1x9gknd 731 31 ; ; : cord-010119-t1x9gknd 731 32 RHCE*ce(733 RHCE*ce(733 NNP cord-010119-t1x9gknd 731 33 G G NNP cord-010119-t1x9gknd 731 34 , , , cord-010119-t1x9gknd 731 35 1006T)/RH*cE:1 1006t)/rh*ce:1 CD cord-010119-t1x9gknd 731 36 ; ; : cord-010119-t1x9gknd 731 37 RHCE*ce(733 RHCE*ce(733 NNP cord-010119-t1x9gknd 731 38 G G NNP cord-010119-t1x9gknd 731 39 , , , cord-010119-t1x9gknd 731 40 1006T)/RH*ce(733G):1 1006T)/RH*ce(733G):1 NNP cord-010119-t1x9gknd 731 41 ; ; : cord-010119-t1x9gknd 731 42 RHCE*ce(733 RHCE*ce(733 NNP cord-010119-t1x9gknd 731 43 G G NNP cord-010119-t1x9gknd 731 44 , , , cord-010119-t1x9gknd 731 45 1006T)/RH*ce(733 1006t)/rh*ce(733 CD cord-010119-t1x9gknd 731 46 G g NN cord-010119-t1x9gknd 731 47 , , , cord-010119-t1x9gknd 731 48 1006T):1 1006t):1 CD cord-010119-t1x9gknd 731 49 ] ] -RRB- cord-010119-t1x9gknd 731 50 . . . cord-010119-t1x9gknd 732 1 In in IN cord-010119-t1x9gknd 732 2 these these DT cord-010119-t1x9gknd 732 3 15 15 CD cord-010119-t1x9gknd 732 4 partial partial JJ cord-010119-t1x9gknd 732 5 C c NN cord-010119-t1x9gknd 732 6 patients patient NNS cord-010119-t1x9gknd 732 7 , , , cord-010119-t1x9gknd 732 8 no no DT cord-010119-t1x9gknd 732 9 anti anti JJ cord-010119-t1x9gknd 732 10 - - JJ cord-010119-t1x9gknd 732 11 C c JJ cord-010119-t1x9gknd 732 12 alloantibodies alloantibody NNS cord-010119-t1x9gknd 732 13 ( ( -LRB- cord-010119-t1x9gknd 732 14 or or CC cord-010119-t1x9gknd 732 15 other other JJ cord-010119-t1x9gknd 732 16 Rh Rh NNP cord-010119-t1x9gknd 732 17 antibodies antibody NNS cord-010119-t1x9gknd 732 18 ) ) -RRB- cord-010119-t1x9gknd 732 19 were be VBD cord-010119-t1x9gknd 732 20 detected detect VBN cord-010119-t1x9gknd 732 21 after after IN cord-010119-t1x9gknd 732 22 60 60 CD cord-010119-t1x9gknd 732 23 transfusion transfusion NN cord-010119-t1x9gknd 732 24 exposures exposure NNS cord-010119-t1x9gknd 732 25 ( ( -LRB- cord-010119-t1x9gknd 732 26 57 57 CD cord-010119-t1x9gknd 732 27 C c NN cord-010119-t1x9gknd 732 28 - - HYPH cord-010119-t1x9gknd 732 29 antigen antigen NN cord-010119-t1x9gknd 732 30 negative negative JJ cord-010119-t1x9gknd 732 31 units unit NNS cord-010119-t1x9gknd 732 32 ; ; : cord-010119-t1x9gknd 732 33 mean mean VB cord-010119-t1x9gknd 732 34 : : : cord-010119-t1x9gknd 732 35 4 4 CD cord-010119-t1x9gknd 732 36 , , , cord-010119-t1x9gknd 732 37 range range NN cord-010119-t1x9gknd 732 38 : : : cord-010119-t1x9gknd 732 39 0 0 CD cord-010119-t1x9gknd 732 40 - - SYM cord-010119-t1x9gknd 732 41 36 36 CD cord-010119-t1x9gknd 732 42 ) ) -RRB- cord-010119-t1x9gknd 732 43 , , , cord-010119-t1x9gknd 732 44 likely likely RB cord-010119-t1x9gknd 732 45 from from IN cord-010119-t1x9gknd 732 46 placement placement NN cord-010119-t1x9gknd 732 47 of of IN cord-010119-t1x9gknd 732 48 a a DT cord-010119-t1x9gknd 732 49 C C NNP cord-010119-t1x9gknd 732 50 - - HYPH cord-010119-t1x9gknd 732 51 negative negative JJ cord-010119-t1x9gknd 732 52 RBC RBC NNP cord-010119-t1x9gknd 732 53 restriction restriction NN cord-010119-t1x9gknd 732 54 upon upon IN cord-010119-t1x9gknd 732 55 detection detection NN cord-010119-t1x9gknd 732 56 of of IN cord-010119-t1x9gknd 732 57 the the DT cord-010119-t1x9gknd 732 58 RHCE*ce(733 RHCE*ce(733 NNP cord-010119-t1x9gknd 732 59 G G NNP cord-010119-t1x9gknd 732 60 , , , cord-010119-t1x9gknd 732 61 1006 1006 CD cord-010119-t1x9gknd 732 62 T t NN cord-010119-t1x9gknd 732 63 ) ) -RRB- cord-010119-t1x9gknd 732 64 allele allele NN cord-010119-t1x9gknd 732 65 . . . cord-010119-t1x9gknd 733 1 Conclusion conclusion NN cord-010119-t1x9gknd 733 2 : : : cord-010119-t1x9gknd 734 1 This this DT cord-010119-t1x9gknd 734 2 report report NN cord-010119-t1x9gknd 734 3 confirms confirm VBZ cord-010119-t1x9gknd 734 4 previous previous JJ cord-010119-t1x9gknd 734 5 data datum NNS cord-010119-t1x9gknd 734 6 of of IN cord-010119-t1x9gknd 734 7 a a DT cord-010119-t1x9gknd 734 8 high high JJ cord-010119-t1x9gknd 734 9 prevalence prevalence NN cord-010119-t1x9gknd 734 10 of of IN cord-010119-t1x9gknd 734 11 the the DT cord-010119-t1x9gknd 734 12 partial partial JJ cord-010119-t1x9gknd 734 13 C C NNP cord-010119-t1x9gknd 734 14 antigen antigen NN cord-010119-t1x9gknd 734 15 in in IN cord-010119-t1x9gknd 734 16 SCD SCD NNP cord-010119-t1x9gknd 734 17 patients patient NNS cord-010119-t1x9gknd 734 18 historically historically RB cord-010119-t1x9gknd 734 19 typed type VBN cord-010119-t1x9gknd 734 20 as as IN cord-010119-t1x9gknd 734 21 C c NN cord-010119-t1x9gknd 734 22 - - HYPH cord-010119-t1x9gknd 734 23 positive positive JJ cord-010119-t1x9gknd 734 24 serologically serologically RB cord-010119-t1x9gknd 734 25 , , , cord-010119-t1x9gknd 734 26 and and CC cord-010119-t1x9gknd 734 27 demonstrates demonstrate VBZ cord-010119-t1x9gknd 734 28 the the DT cord-010119-t1x9gknd 734 29 benefits benefit NNS cord-010119-t1x9gknd 734 30 of of IN cord-010119-t1x9gknd 734 31 RBC RBC NNP cord-010119-t1x9gknd 734 32 genotyping genotyping NN cord-010119-t1x9gknd 734 33 to to TO cord-010119-t1x9gknd 734 34 prevent prevent VB cord-010119-t1x9gknd 734 35 alloimmunization alloimmunization NN cord-010119-t1x9gknd 734 36 to to IN cord-010119-t1x9gknd 734 37 a a DT cord-010119-t1x9gknd 734 38 highly highly RB cord-010119-t1x9gknd 734 39 immunogenic immunogenic JJ cord-010119-t1x9gknd 734 40 Rh Rh NNP cord-010119-t1x9gknd 734 41 antigen antigen NN cord-010119-t1x9gknd 734 42 by by IN cord-010119-t1x9gknd 734 43 identifying identify VBG cord-010119-t1x9gknd 734 44 individuals individual NNS cord-010119-t1x9gknd 734 45 who who WP cord-010119-t1x9gknd 734 46 should should MD cord-010119-t1x9gknd 734 47 receive receive VB cord-010119-t1x9gknd 734 48 C c NN cord-010119-t1x9gknd 734 49 - - HYPH cord-010119-t1x9gknd 734 50 negative negative JJ cord-010119-t1x9gknd 734 51 blood blood NN cord-010119-t1x9gknd 734 52 . . . cord-010119-t1x9gknd 735 1 All all DT cord-010119-t1x9gknd 735 2 patients patient NNS cord-010119-t1x9gknd 735 3 with with IN cord-010119-t1x9gknd 735 4 SCD SCD NNP cord-010119-t1x9gknd 735 5 should should MD cord-010119-t1x9gknd 735 6 have have VB cord-010119-t1x9gknd 735 7 RBC RBC NNP cord-010119-t1x9gknd 735 8 genotyping genotyping NN cord-010119-t1x9gknd 735 9 performed perform VBN cord-010119-t1x9gknd 735 10 for for IN cord-010119-t1x9gknd 735 11 determination determination NN cord-010119-t1x9gknd 735 12 of of IN cord-010119-t1x9gknd 735 13 their -PRON- PRP$ cord-010119-t1x9gknd 735 14 RBC RBC NNP cord-010119-t1x9gknd 735 15 phenotype phenotype NN cord-010119-t1x9gknd 735 16 , , , cord-010119-t1x9gknd 735 17 preferably preferably RB cord-010119-t1x9gknd 735 18 prior prior RB cord-010119-t1x9gknd 735 19 to to IN cord-010119-t1x9gknd 735 20 receiving receive VBG cord-010119-t1x9gknd 735 21 transfusions transfusion NNS cord-010119-t1x9gknd 735 22 . . . cord-010119-t1x9gknd 736 1 Investigational Investigational NNP cord-010119-t1x9gknd 736 2 Detection Detection NNP cord-010119-t1x9gknd 736 3 of of IN cord-010119-t1x9gknd 736 4 Zika Zika NNP cord-010119-t1x9gknd 736 5 Virus Virus NNP cord-010119-t1x9gknd 736 6 RNA RNA NNP cord-010119-t1x9gknd 736 7 in in IN cord-010119-t1x9gknd 736 8 US US NNP cord-010119-t1x9gknd 736 9 Blood Blood NNP cord-010119-t1x9gknd 736 10 Donors Donors NNPS cord-010119-t1x9gknd 736 11 Paula Paula NNP cord-010119-t1x9gknd 736 12 P P NNP cord-010119-t1x9gknd 736 13 Sa Sa NNP cord-010119-t1x9gknd 736 14 a a DT cord-010119-t1x9gknd 736 15 * * NN cord-010119-t1x9gknd 736 16 1 1 CD cord-010119-t1x9gknd 736 17 , , , cord-010119-t1x9gknd 736 18 Megan Megan NNP cord-010119-t1x9gknd 736 19 L L NNP cord-010119-t1x9gknd 736 20 Nguyen Nguyen NNP cord-010119-t1x9gknd 736 21 1 1 CD cord-010119-t1x9gknd 736 22 , , , cord-010119-t1x9gknd 736 23 Melanie Melanie NNP cord-010119-t1x9gknd 736 24 C C NNP cord-010119-t1x9gknd 736 25 Proctor Proctor NNP cord-010119-t1x9gknd 736 26 1 1 CD cord-010119-t1x9gknd 736 27 , , , cord-010119-t1x9gknd 736 28 David David NNP cord-010119-t1x9gknd 736 29 E E NNP cord-010119-t1x9gknd 736 30 Krysztof Krysztof NNP cord-010119-t1x9gknd 736 31 1 1 CD cord-010119-t1x9gknd 736 32 , , , cord-010119-t1x9gknd 736 33 Gregory Gregory NNP cord-010119-t1x9gknd 736 34 A A NNP cord-010119-t1x9gknd 736 35 Foster Foster NNP cord-010119-t1x9gknd 736 36 1 1 CD cord-010119-t1x9gknd 736 37 , , , cord-010119-t1x9gknd 736 38 Erin Erin NNP cord-010119-t1x9gknd 736 39 K K NNP cord-010119-t1x9gknd 736 40 Sash Sash NNP cord-010119-t1x9gknd 736 41 1 1 CD cord-010119-t1x9gknd 736 42 , , , cord-010119-t1x9gknd 736 43 Sandy Sandy NNP cord-010119-t1x9gknd 736 44 S S NNP cord-010119-t1x9gknd 736 45 Dickson Dickson NNP cord-010119-t1x9gknd 736 46 1 1 CD cord-010119-t1x9gknd 736 47 , , , cord-010119-t1x9gknd 736 48 Joua Joua NNP cord-010119-t1x9gknd 736 49 Yang Yang NNP cord-010119-t1x9gknd 736 50 1 1 CD cord-010119-t1x9gknd 736 51 , , , cord-010119-t1x9gknd 736 52 Jeffrey Jeffrey NNP cord-010119-t1x9gknd 736 53 M M NNP cord-010119-t1x9gknd 736 54 Linnen Linnen NNP cord-010119-t1x9gknd 736 55 2 2 CD cord-010119-t1x9gknd 736 56 , , , cord-010119-t1x9gknd 736 57 Kui Kui NNP cord-010119-t1x9gknd 736 58 Gao Gao NNP cord-010119-t1x9gknd 736 59 3 3 CD cord-010119-t1x9gknd 736 60 , , , cord-010119-t1x9gknd 736 61 Jaye Jaye NNP cord-010119-t1x9gknd 736 62 P P NNP cord-010119-t1x9gknd 736 63 Brodsky Brodsky NNP cord-010119-t1x9gknd 736 64 4 4 CD cord-010119-t1x9gknd 736 65 and and CC cord-010119-t1x9gknd 736 66 Susan Susan NNP cord-010119-t1x9gknd 736 67 L L NNP cord-010119-t1x9gknd 736 68 Stramer Stramer NNP cord-010119-t1x9gknd 736 69 1 1 CD cord-010119-t1x9gknd 736 70 . . . cord-010119-t1x9gknd 737 1 1 1 CD cord-010119-t1x9gknd 737 2 American American NNP cord-010119-t1x9gknd 737 3 Red Red NNP cord-010119-t1x9gknd 737 4 Cross Cross NNP cord-010119-t1x9gknd 737 5 , , , cord-010119-t1x9gknd 737 6 2 2 CD cord-010119-t1x9gknd 737 7 Grifols Grifols NNP cord-010119-t1x9gknd 737 8 Diagnostic Diagnostic NNP cord-010119-t1x9gknd 737 9 Solutions Solutions NNPS cord-010119-t1x9gknd 737 10 Inc. Inc. NNP cord-010119-t1x9gknd 737 11 , , , cord-010119-t1x9gknd 737 12 3 3 CD cord-010119-t1x9gknd 737 13 Grifols Grifols NNP cord-010119-t1x9gknd 737 14 Diagnostic Diagnostic NNP cord-010119-t1x9gknd 737 15 Solutions Solutions NNPS cord-010119-t1x9gknd 737 16 , , , cord-010119-t1x9gknd 737 17 Inc Inc NNP cord-010119-t1x9gknd 737 18 , , , cord-010119-t1x9gknd 737 19 4 4 CD cord-010119-t1x9gknd 737 20 Quality Quality NNP cord-010119-t1x9gknd 737 21 Analytics Analytics NNP cord-010119-t1x9gknd 737 22 , , , cord-010119-t1x9gknd 738 1 Inc Inc NNP cord-010119-t1x9gknd 738 2 Background Background NNP cord-010119-t1x9gknd 738 3 / / SYM cord-010119-t1x9gknd 738 4 Case Case NNP cord-010119-t1x9gknd 738 5 Studies Studies NNPS cord-010119-t1x9gknd 738 6 : : : cord-010119-t1x9gknd 739 1 Zika Zika NNP cord-010119-t1x9gknd 739 2 virus virus NN cord-010119-t1x9gknd 739 3 ( ( -LRB- cord-010119-t1x9gknd 739 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 739 5 ) ) -RRB- cord-010119-t1x9gknd 739 6 , , , cord-010119-t1x9gknd 739 7 an an DT cord-010119-t1x9gknd 739 8 emerging emerge VBG cord-010119-t1x9gknd 739 9 flavivirus flavivirus NN cord-010119-t1x9gknd 739 10 , , , cord-010119-t1x9gknd 739 11 is be VBZ cord-010119-t1x9gknd 739 12 primarily primarily RB cord-010119-t1x9gknd 739 13 transmitted transmit VBN cord-010119-t1x9gknd 739 14 by by IN cord-010119-t1x9gknd 739 15 infected infected JJ cord-010119-t1x9gknd 739 16 Aedes Aedes NNP cord-010119-t1x9gknd 739 17 aegypti aegypti NN cord-010119-t1x9gknd 739 18 mosquitoes mosquito NNS cord-010119-t1x9gknd 739 19 , , , cord-010119-t1x9gknd 739 20 but but CC cord-010119-t1x9gknd 739 21 recent recent JJ cord-010119-t1x9gknd 739 22 outbreaks outbreak NNS cord-010119-t1x9gknd 739 23 have have VBP cord-010119-t1x9gknd 739 24 revealed reveal VBN cord-010119-t1x9gknd 739 25 non non JJ cord-010119-t1x9gknd 739 26 - - JJ cord-010119-t1x9gknd 739 27 vector vector JJ cord-010119-t1x9gknd 739 28 transmission transmission NN cord-010119-t1x9gknd 739 29 routes route NNS cord-010119-t1x9gknd 739 30 including include VBG cord-010119-t1x9gknd 739 31 the the DT cord-010119-t1x9gknd 739 32 unprecedented unprecedented JJ cord-010119-t1x9gknd 739 33 sexual sexual JJ cord-010119-t1x9gknd 739 34 transmission transmission NN cord-010119-t1x9gknd 739 35 of of IN cord-010119-t1x9gknd 739 36 an an DT cord-010119-t1x9gknd 739 37 arbovirus arbovirus NN cord-010119-t1x9gknd 739 38 . . . cord-010119-t1x9gknd 740 1 Acute acute JJ cord-010119-t1x9gknd 740 2 ZIKV ZIKV NNP cord-010119-t1x9gknd 740 3 infection infection NN cord-010119-t1x9gknd 740 4 is be VBZ cord-010119-t1x9gknd 740 5 mainly mainly RB cord-010119-t1x9gknd 740 6 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 740 7 or or CC cord-010119-t1x9gknd 740 8 presents present VBZ cord-010119-t1x9gknd 740 9 as as IN cord-010119-t1x9gknd 740 10 a a DT cord-010119-t1x9gknd 740 11 self self NN cord-010119-t1x9gknd 740 12 - - HYPH cord-010119-t1x9gknd 740 13 limited limit VBN cord-010119-t1x9gknd 740 14 disease disease NN cord-010119-t1x9gknd 740 15 but but CC cord-010119-t1x9gknd 740 16 also also RB cord-010119-t1x9gknd 740 17 includes include VBZ cord-010119-t1x9gknd 740 18 severe severe JJ cord-010119-t1x9gknd 740 19 congenital congenital JJ cord-010119-t1x9gknd 740 20 defects defect NNS cord-010119-t1x9gknd 740 21 and and CC cord-010119-t1x9gknd 740 22 neurologic neurologic JJ cord-010119-t1x9gknd 740 23 disorders disorder NNS cord-010119-t1x9gknd 740 24 . . . cord-010119-t1x9gknd 741 1 The the DT cord-010119-t1x9gknd 741 2 large large JJ cord-010119-t1x9gknd 741 3 proportion proportion NN cord-010119-t1x9gknd 741 4 of of IN cord-010119-t1x9gknd 741 5 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 741 6 cases case NNS cord-010119-t1x9gknd 741 7 , , , cord-010119-t1x9gknd 741 8 high high JJ cord-010119-t1x9gknd 741 9 numbers number NNS cord-010119-t1x9gknd 741 10 of of IN cord-010119-t1x9gknd 741 11 returning return VBG cord-010119-t1x9gknd 741 12 travelers traveler NNS cord-010119-t1x9gknd 741 13 from from IN cord-010119-t1x9gknd 741 14 ZIKV zikv NN cord-010119-t1x9gknd 741 15 - - HYPH cord-010119-t1x9gknd 741 16 active active JJ cord-010119-t1x9gknd 741 17 areas area NNS cord-010119-t1x9gknd 741 18 , , , cord-010119-t1x9gknd 741 19 severe severe JJ cord-010119-t1x9gknd 741 20 clinical clinical JJ cord-010119-t1x9gknd 741 21 consequences consequence NNS cord-010119-t1x9gknd 741 22 to to IN cord-010119-t1x9gknd 741 23 developing develop VBG cord-010119-t1x9gknd 741 24 fetuses fetus NNS cord-010119-t1x9gknd 741 25 , , , cord-010119-t1x9gknd 741 26 the the DT cord-010119-t1x9gknd 741 27 detection detection NN cord-010119-t1x9gknd 741 28 of of IN cord-010119-t1x9gknd 741 29 RNA RNA NNP cord-010119-t1x9gknd 741 30 in in IN cord-010119-t1x9gknd 741 31 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 741 32 donors donor NNS cord-010119-t1x9gknd 741 33 during during IN cord-010119-t1x9gknd 741 34 the the DT cord-010119-t1x9gknd 741 35 French French NNP cord-010119-t1x9gknd 741 36 Polynesia Polynesia NNP cord-010119-t1x9gknd 741 37 epidemic epidemic NN cord-010119-t1x9gknd 741 38 , , , cord-010119-t1x9gknd 741 39 and and CC cord-010119-t1x9gknd 741 40 4 4 CD cord-010119-t1x9gknd 741 41 suspected suspect VBN cord-010119-t1x9gknd 741 42 cases case NNS cord-010119-t1x9gknd 741 43 of of IN cord-010119-t1x9gknd 741 44 transfusion transfusion NN cord-010119-t1x9gknd 741 45 transmission transmission NN cord-010119-t1x9gknd 741 46 in in IN cord-010119-t1x9gknd 741 47 Brazil Brazil NNP cord-010119-t1x9gknd 741 48 led lead VBD cord-010119-t1x9gknd 741 49 FDA FDA NNP cord-010119-t1x9gknd 741 50 to to TO cord-010119-t1x9gknd 741 51 release release VB cord-010119-t1x9gknd 741 52 guidance guidance NN cord-010119-t1x9gknd 741 53 documents document NNS cord-010119-t1x9gknd 741 54 to to TO cord-010119-t1x9gknd 741 55 minimize minimize VB cord-010119-t1x9gknd 741 56 the the DT cord-010119-t1x9gknd 741 57 risk risk NN cord-010119-t1x9gknd 741 58 of of IN cord-010119-t1x9gknd 741 59 ZIKV ZIKV NNP cord-010119-t1x9gknd 741 60 transmission transmission NN cord-010119-t1x9gknd 741 61 via via IN cord-010119-t1x9gknd 741 62 blood/ blood/ CD cord-010119-t1x9gknd 741 63 blood blood NN cord-010119-t1x9gknd 741 64 components component NNS cord-010119-t1x9gknd 741 65 . . . cord-010119-t1x9gknd 742 1 Study Study NNP cord-010119-t1x9gknd 742 2 Design Design NNP cord-010119-t1x9gknd 742 3 / / SYM cord-010119-t1x9gknd 742 4 Method method NN cord-010119-t1x9gknd 742 5 : : : cord-010119-t1x9gknd 743 1 Investigational investigational JJ cord-010119-t1x9gknd 743 2 testing testing NN cord-010119-t1x9gknd 743 3 by by IN cord-010119-t1x9gknd 743 4 mini mini JJ cord-010119-t1x9gknd 743 5 - - NN cord-010119-t1x9gknd 743 6 pool pool NN cord-010119-t1x9gknd 743 7 ( ( -LRB- cord-010119-t1x9gknd 743 8 MP)-NAT mp)-nat NN cord-010119-t1x9gknd 743 9 using use VBG cord-010119-t1x9gknd 743 10 the the DT cord-010119-t1x9gknd 743 11 Procleix Procleix NNP cord-010119-t1x9gknd 743 12 Zika Zika NNP cord-010119-t1x9gknd 743 13 Virus Virus NNP cord-010119-t1x9gknd 743 14 Assay Assay NNP cord-010119-t1x9gknd 743 15 ( ( -LRB- cord-010119-t1x9gknd 743 16 TMA TMA NNP cord-010119-t1x9gknd 743 17 ) ) -RRB- cord-010119-t1x9gknd 743 18 was be VBD cord-010119-t1x9gknd 743 19 implemented implement VBN cord-010119-t1x9gknd 743 20 on on IN cord-010119-t1x9gknd 743 21 collections collection NNS cord-010119-t1x9gknd 743 22 from from IN cord-010119-t1x9gknd 743 23 five five CD cord-010119-t1x9gknd 743 24 presumed presumed JJ cord-010119-t1x9gknd 743 25 high high JJ cord-010119-t1x9gknd 743 26 - - HYPH cord-010119-t1x9gknd 743 27 risk risk NN cord-010119-t1x9gknd 743 28 US US NNP cord-010119-t1x9gknd 743 29 states state NNS cord-010119-t1x9gknd 743 30 on on IN cord-010119-t1x9gknd 743 31 6/20/16 6/20/16 CD cord-010119-t1x9gknd 743 32 ( ( -LRB- cord-010119-t1x9gknd 743 33 FL FL NNP cord-010119-t1x9gknd 743 34 , , , cord-010119-t1x9gknd 743 35 GA GA NNP cord-010119-t1x9gknd 743 36 , , , cord-010119-t1x9gknd 743 37 SC SC NNP cord-010119-t1x9gknd 743 38 , , , cord-010119-t1x9gknd 743 39 MS MS NNP cord-010119-t1x9gknd 743 40 , , , cord-010119-t1x9gknd 743 41 AL AL NNP cord-010119-t1x9gknd 743 42 ) ) -RRB- cord-010119-t1x9gknd 743 43 . . . cord-010119-t1x9gknd 744 1 Following follow VBG cord-010119-t1x9gknd 744 2 revised revised JJ cord-010119-t1x9gknd 744 3 guidance guidance NN cord-010119-t1x9gknd 744 4 on on IN cord-010119-t1x9gknd 744 5 8/26/16 8/26/16 CD cord-010119-t1x9gknd 744 6 , , , cord-010119-t1x9gknd 744 7 testing testing NN cord-010119-t1x9gknd 744 8 was be VBD cord-010119-t1x9gknd 744 9 extended extend VBN cord-010119-t1x9gknd 744 10 to to IN cord-010119-t1x9gknd 744 11 all all DT cord-010119-t1x9gknd 744 12 blood blood NN cord-010119-t1x9gknd 744 13 donations donation NNS cord-010119-t1x9gknd 744 14 ; ; : cord-010119-t1x9gknd 744 15 conversion conversion NN cord-010119-t1x9gknd 744 16 from from IN cord-010119-t1x9gknd 744 17 MP MP NNP cord-010119-t1x9gknd 744 18 - - HYPH cord-010119-t1x9gknd 744 19 NAT NAT NNP cord-010119-t1x9gknd 744 20 to to IN cord-010119-t1x9gknd 744 21 individual individual JJ cord-010119-t1x9gknd 744 22 donation donation NN cord-010119-t1x9gknd 745 1 ( ( -LRB- cord-010119-t1x9gknd 745 2 ID)-NAT ID)-NAT NNP cord-010119-t1x9gknd 745 3 was be VBD cord-010119-t1x9gknd 745 4 implemented implement VBN cord-010119-t1x9gknd 745 5 in in IN cord-010119-t1x9gknd 745 6 phases phase NNS cord-010119-t1x9gknd 745 7 and and CC cord-010119-t1x9gknd 745 8 completed complete VBN cord-010119-t1x9gknd 745 9 on on IN cord-010119-t1x9gknd 745 10 12/12/16 12/12/16 CD cord-010119-t1x9gknd 745 11 . . . cord-010119-t1x9gknd 746 1 Travel travel NN cord-010119-t1x9gknd 746 2 history history NN cord-010119-t1x9gknd 746 3 questions question NNS cord-010119-t1x9gknd 746 4 were be VBD cord-010119-t1x9gknd 746 5 discontinued discontinue VBN cord-010119-t1x9gknd 746 6 on on IN cord-010119-t1x9gknd 746 7 1/23/17 1/23/17 CD cord-010119-t1x9gknd 746 8 . . . cord-010119-t1x9gknd 747 1 Confirmatory confirmatory JJ cord-010119-t1x9gknd 747 2 testing testing NN cord-010119-t1x9gknd 747 3 included include VBD cord-010119-t1x9gknd 747 4 repeat repeat NN cord-010119-t1x9gknd 747 5 TMA TMA NNP cord-010119-t1x9gknd 747 6 ; ; : cord-010119-t1x9gknd 747 7 in in IN cord-010119-t1x9gknd 747 8 addition addition NN cord-010119-t1x9gknd 747 9 , , , cord-010119-t1x9gknd 747 10 RT RT NNP cord-010119-t1x9gknd 747 11 - - HYPH cord-010119-t1x9gknd 747 12 PCR PCR NNP cord-010119-t1x9gknd 747 13 , , , cord-010119-t1x9gknd 747 14 serology serology NN cord-010119-t1x9gknd 747 15 and and CC cord-010119-t1x9gknd 747 16 red red JJ cord-010119-t1x9gknd 747 17 cell cell NN cord-010119-t1x9gknd 747 18 ( ( -LRB- cord-010119-t1x9gknd 747 19 RBC RBC NNP cord-010119-t1x9gknd 747 20 ) ) -RRB- cord-010119-t1x9gknd 747 21 TMA TMA NNP cord-010119-t1x9gknd 747 22 were be VBD cord-010119-t1x9gknd 747 23 performed perform VBN cord-010119-t1x9gknd 747 24 . . . cord-010119-t1x9gknd 748 1 Estimates estimate NNS cord-010119-t1x9gknd 748 2 of of IN cord-010119-t1x9gknd 748 3 viral viral JJ cord-010119-t1x9gknd 748 4 loads load NNS cord-010119-t1x9gknd 748 5 were be VBD cord-010119-t1x9gknd 748 6 performed perform VBN cord-010119-t1x9gknd 748 7 by by IN cord-010119-t1x9gknd 748 8 end end NN cord-010119-t1x9gknd 748 9 - - HYPH cord-010119-t1x9gknd 748 10 point point NN cord-010119-t1x9gknd 748 11 TMA TMA NNP cord-010119-t1x9gknd 748 12 on on IN cord-010119-t1x9gknd 748 13 plasma plasma NN cord-010119-t1x9gknd 748 14 and and CC cord-010119-t1x9gknd 748 15 RBCs rbc NNS cord-010119-t1x9gknd 748 16 . . . cord-010119-t1x9gknd 749 1 Results result NNS cord-010119-t1x9gknd 749 2 / / SYM cord-010119-t1x9gknd 749 3 Finding finding NN cord-010119-t1x9gknd 749 4 : : : cord-010119-t1x9gknd 750 1 As as IN cord-010119-t1x9gknd 750 2 of of IN cord-010119-t1x9gknd 750 3 4/8/17 4/8/17 CD cord-010119-t1x9gknd 750 4 , , , cord-010119-t1x9gknd 750 5 2,288,855 2,288,855 CD cord-010119-t1x9gknd 750 6 donations donation NNS cord-010119-t1x9gknd 750 7 were be VBD cord-010119-t1x9gknd 750 8 tested test VBN cord-010119-t1x9gknd 750 9 including include VBG cord-010119-t1x9gknd 750 10 393,713 393,713 CD cord-010119-t1x9gknd 750 11 ( ( -LRB- cord-010119-t1x9gknd 750 12 17 17 CD cord-010119-t1x9gknd 750 13 % % NN cord-010119-t1x9gknd 750 14 ) ) -RRB- cord-010119-t1x9gknd 750 15 in in IN cord-010119-t1x9gknd 750 16 24,611 24,611 CD cord-010119-t1x9gknd 750 17 MPs mp NNS cord-010119-t1x9gknd 750 18 . . . cord-010119-t1x9gknd 751 1 No no DT cord-010119-t1x9gknd 751 2 reactive reactive JJ cord-010119-t1x9gknd 751 3 donations donation NNS cord-010119-t1x9gknd 751 4 were be VBD cord-010119-t1x9gknd 751 5 identified identify VBN cord-010119-t1x9gknd 751 6 by by IN cord-010119-t1x9gknd 751 7 MP MP NNP cord-010119-t1x9gknd 751 8 - - HYPH cord-010119-t1x9gknd 751 9 NAT NAT NNP cord-010119-t1x9gknd 751 10 . . . cord-010119-t1x9gknd 752 1 Of of IN cord-010119-t1x9gknd 752 2 the the DT cord-010119-t1x9gknd 752 3 1,895,142 1,895,142 CD cord-010119-t1x9gknd 752 4 ID ID NNP cord-010119-t1x9gknd 752 5 - - HYPH cord-010119-t1x9gknd 752 6 NAT NAT NNP cord-010119-t1x9gknd 752 7 donations donation NNS cord-010119-t1x9gknd 752 8 , , , cord-010119-t1x9gknd 752 9 72 72 CD cord-010119-t1x9gknd 752 10 were be VBD cord-010119-t1x9gknd 752 11 initial initial JJ cord-010119-t1x9gknd 752 12 reactive reactive JJ cord-010119-t1x9gknd 752 13 ( ( -LRB- cord-010119-t1x9gknd 752 14 IR IR NNP cord-010119-t1x9gknd 752 15 ) ) -RRB- cord-010119-t1x9gknd 752 16 of of IN cord-010119-t1x9gknd 752 17 which which WDT cord-010119-t1x9gknd 752 18 8 8 CD cord-010119-t1x9gknd 752 19 ( ( -LRB- cord-010119-t1x9gknd 752 20 11 11 CD cord-010119-t1x9gknd 752 21 % % NN cord-010119-t1x9gknd 752 22 ) ) -RRB- cord-010119-t1x9gknd 752 23 confirmed confirm VBD cord-010119-t1x9gknd 752 24 positive positive JJ cord-010119-t1x9gknd 752 25 ( ( -LRB- cord-010119-t1x9gknd 752 26 CP cp NN cord-010119-t1x9gknd 752 27 ) ) -RRB- cord-010119-t1x9gknd 752 28 by by IN cord-010119-t1x9gknd 752 29 subsequent subsequent JJ cord-010119-t1x9gknd 752 30 testing testing NN cord-010119-t1x9gknd 752 31 ( ( -LRB- cord-010119-t1x9gknd 752 32 CP cp NN cord-010119-t1x9gknd 752 33 rate rate NN cord-010119-t1x9gknd 752 34 of of IN cord-010119-t1x9gknd 752 35 1:286,107 1:286,107 CD cord-010119-t1x9gknd 752 36 ; ; , cord-010119-t1x9gknd 752 37 positive positive JJ cord-010119-t1x9gknd 752 38 predictive predictive JJ cord-010119-t1x9gknd 752 39 value value NN cord-010119-t1x9gknd 752 40 of of IN cord-010119-t1x9gknd 752 41 11 11 CD cord-010119-t1x9gknd 752 42 % % NN cord-010119-t1x9gknd 752 43 ; ; , cord-010119-t1x9gknd 752 44 specificity specificity NN cord-010119-t1x9gknd 752 45 of of IN cord-010119-t1x9gknd 752 46 99.997 99.997 CD cord-010119-t1x9gknd 752 47 % % NN cord-010119-t1x9gknd 752 48 ) ) -RRB- cord-010119-t1x9gknd 752 49 . . . cord-010119-t1x9gknd 753 1 Five five CD cord-010119-t1x9gknd 753 2 ( ( -LRB- cord-010119-t1x9gknd 753 3 62 62 CD cord-010119-t1x9gknd 753 4 % % NN cord-010119-t1x9gknd 753 5 ) ) -RRB- cord-010119-t1x9gknd 754 1 CP cp NN cord-010119-t1x9gknd 754 2 donations donation NNS cord-010119-t1x9gknd 754 3 were be VBD cord-010119-t1x9gknd 754 4 ID ID NNP cord-010119-t1x9gknd 754 5 - - HYPH cord-010119-t1x9gknd 754 6 NAT NAT NNP cord-010119-t1x9gknd 754 7 repeat repeat NN cord-010119-t1x9gknd 754 8 reactive reactive JJ cord-010119-t1x9gknd 754 9 ( ( -LRB- cord-010119-t1x9gknd 754 10 RR RR NNP cord-010119-t1x9gknd 754 11 ) ) -RRB- cord-010119-t1x9gknd 754 12 ; ; : cord-010119-t1x9gknd 754 13 3 3 CD cord-010119-t1x9gknd 754 14 ( ( -LRB- cord-010119-t1x9gknd 754 15 38 38 CD cord-010119-t1x9gknd 754 16 % % NN cord-010119-t1x9gknd 754 17 ) ) -RRB- cord-010119-t1x9gknd 754 18 donations donation NNS cord-010119-t1x9gknd 754 19 were be VBD cord-010119-t1x9gknd 754 20 ID ID NNP cord-010119-t1x9gknd 754 21 - - HYPH cord-010119-t1x9gknd 754 22 NAT NAT NNP cord-010119-t1x9gknd 754 23 IR IR NNP cord-010119-t1x9gknd 754 24 only only RB cord-010119-t1x9gknd 754 25 , , , cord-010119-t1x9gknd 754 26 IgM IgM NNP cord-010119-t1x9gknd 754 27 positive positive NNP cord-010119-t1x9gknd 754 28 and and CC cord-010119-t1x9gknd 754 29 RNA RNA NNP cord-010119-t1x9gknd 754 30 positive positive JJ cord-010119-t1x9gknd 754 31 in in IN cord-010119-t1x9gknd 754 32 RBCs rbc NNS cord-010119-t1x9gknd 754 33 . . . cord-010119-t1x9gknd 755 1 CP CP NNP cord-010119-t1x9gknd 755 2 donors donor NNS cord-010119-t1x9gknd 755 3 resided reside VBD cord-010119-t1x9gknd 755 4 in in IN cord-010119-t1x9gknd 755 5 MA MA NNP cord-010119-t1x9gknd 755 6 , , , cord-010119-t1x9gknd 755 7 TX TX NNP cord-010119-t1x9gknd 755 8 , , , cord-010119-t1x9gknd 755 9 CA CA NNP cord-010119-t1x9gknd 755 10 , , , cord-010119-t1x9gknd 755 11 NY NY NNP cord-010119-t1x9gknd 755 12 , , , cord-010119-t1x9gknd 755 13 WV WV NNP cord-010119-t1x9gknd 755 14 and and CC cord-010119-t1x9gknd 755 15 3 3 CD cord-010119-t1x9gknd 755 16 in in IN cord-010119-t1x9gknd 755 17 FL FL NNP cord-010119-t1x9gknd 755 18 , , , cord-010119-t1x9gknd 755 19 2 2 CD cord-010119-t1x9gknd 755 20 of of IN cord-010119-t1x9gknd 755 21 which which WDT cord-010119-t1x9gknd 755 22 were be VBD cord-010119-t1x9gknd 755 23 local local JJ cord-010119-t1x9gknd 755 24 transmissions transmission NNS cord-010119-t1x9gknd 755 25 . . . cord-010119-t1x9gknd 756 1 Six six CD cord-010119-t1x9gknd 756 2 donors donor NNS cord-010119-t1x9gknd 756 3 had have VBD cord-010119-t1x9gknd 756 4 traveled travel VBN cord-010119-t1x9gknd 756 5 to to IN cord-010119-t1x9gknd 756 6 a a DT cord-010119-t1x9gknd 756 7 ZIKV zikv NN cord-010119-t1x9gknd 756 8 - - HYPH cord-010119-t1x9gknd 756 9 active active JJ cord-010119-t1x9gknd 756 10 area area NN cord-010119-t1x9gknd 756 11 returning return VBG cord-010119-t1x9gknd 756 12 to to IN cord-010119-t1x9gknd 756 13 the the DT cord-010119-t1x9gknd 756 14 US US NNP cord-010119-t1x9gknd 756 15 from from IN cord-010119-t1x9gknd 756 16 2 2 CD cord-010119-t1x9gknd 756 17 to to TO cord-010119-t1x9gknd 756 18 73 73 CD cord-010119-t1x9gknd 756 19 days day NNS cord-010119-t1x9gknd 756 20 prior prior RB cord-010119-t1x9gknd 756 21 to to IN cord-010119-t1x9gknd 756 22 donation donation NN cord-010119-t1x9gknd 756 23 . . . cord-010119-t1x9gknd 757 1 Two two CD cord-010119-t1x9gknd 757 2 donors donor NNS cord-010119-t1x9gknd 757 3 with with IN cord-010119-t1x9gknd 757 4 a a DT cord-010119-t1x9gknd 757 5 travel travel NN cord-010119-t1x9gknd 757 6 risk risk NN cord-010119-t1x9gknd 757 7 reported report VBD cord-010119-t1x9gknd 757 8 clinical clinical JJ cord-010119-t1x9gknd 757 9 symptoms symptom NNS cord-010119-t1x9gknd 757 10 ; ; : cord-010119-t1x9gknd 757 11 6 6 CD cord-010119-t1x9gknd 757 12 CP cp NN cord-010119-t1x9gknd 757 13 donors donor NNS cord-010119-t1x9gknd 757 14 ( ( -LRB- cord-010119-t1x9gknd 757 15 75 75 CD cord-010119-t1x9gknd 757 16 % % NN cord-010119-t1x9gknd 757 17 ) ) -RRB- cord-010119-t1x9gknd 757 18 remained remain VBD cord-010119-t1x9gknd 757 19 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 757 20 . . . cord-010119-t1x9gknd 758 1 ZIKV ZIKV NNP cord-010119-t1x9gknd 758 2 RNA RNA NNP cord-010119-t1x9gknd 758 3 was be VBD cord-010119-t1x9gknd 758 4 detected detect VBN cord-010119-t1x9gknd 758 5 in in IN cord-010119-t1x9gknd 758 6 RBCs rbc NNS cord-010119-t1x9gknd 758 7 from from IN cord-010119-t1x9gknd 758 8 all all DT cord-010119-t1x9gknd 758 9 CP cp NN cord-010119-t1x9gknd 758 10 index index NN cord-010119-t1x9gknd 758 11 donations donation NNS cord-010119-t1x9gknd 758 12 with with IN cord-010119-t1x9gknd 758 13 estimated estimate VBN cord-010119-t1x9gknd 758 14 levels level NNS cord-010119-t1x9gknd 758 15 varying vary VBG cord-010119-t1x9gknd 758 16 from from IN cord-010119-t1x9gknd 758 17 less less JJR cord-010119-t1x9gknd 758 18 than than IN cord-010119-t1x9gknd 758 19 40 40 CD cord-010119-t1x9gknd 758 20 copies copy NNS cord-010119-t1x9gknd 758 21 ( ( -LRB- cord-010119-t1x9gknd 758 22 c)/mL c)/mL VBZ cord-010119-t1x9gknd 758 23 to to IN cord-010119-t1x9gknd 758 24 about about RB cord-010119-t1x9gknd 758 25 8Ê 8ê CD cord-010119-t1x9gknd 758 26 5 5 CD cord-010119-t1x9gknd 759 1 c c NNP cord-010119-t1x9gknd 759 2 / / SYM cord-010119-t1x9gknd 759 3 mL. mL. NNP cord-010119-t1x9gknd 760 1 At at IN cord-010119-t1x9gknd 760 2 the the DT cord-010119-t1x9gknd 760 3 time time NN cord-010119-t1x9gknd 760 4 of of IN cord-010119-t1x9gknd 760 5 writing writing NN cord-010119-t1x9gknd 760 6 , , , cord-010119-t1x9gknd 760 7 the the DT cord-010119-t1x9gknd 760 8 longest long JJS cord-010119-t1x9gknd 760 9 period period NN cord-010119-t1x9gknd 760 10 of of IN cord-010119-t1x9gknd 760 11 detection detection NN cord-010119-t1x9gknd 760 12 in in IN cord-010119-t1x9gknd 760 13 RBCs rbc NNS cord-010119-t1x9gknd 760 14 was be VBD cord-010119-t1x9gknd 760 15 91 91 CD cord-010119-t1x9gknd 760 16 days day NNS cord-010119-t1x9gknd 760 17 vs. vs. IN cord-010119-t1x9gknd 760 18 17 17 CD cord-010119-t1x9gknd 760 19 days day NNS cord-010119-t1x9gknd 760 20 in in IN cord-010119-t1x9gknd 760 21 plasma plasma NN cord-010119-t1x9gknd 760 22 from from IN cord-010119-t1x9gknd 760 23 the the DT cord-010119-t1x9gknd 760 24 same same JJ cord-010119-t1x9gknd 760 25 TMA TMA NNP cord-010119-t1x9gknd 760 26 - - HYPH cord-010119-t1x9gknd 760 27 RR RR NNP cord-010119-t1x9gknd 760 28 donor donor NN cord-010119-t1x9gknd 760 29 . . . cord-010119-t1x9gknd 761 1 ZIKV ZIKV NNP cord-010119-t1x9gknd 761 2 RNA RNA NNP cord-010119-t1x9gknd 761 3 levels level NNS cord-010119-t1x9gknd 761 4 in in IN cord-010119-t1x9gknd 761 5 plasma plasma NN cord-010119-t1x9gknd 761 6 were be VBD cord-010119-t1x9gknd 761 7 obtained obtain VBN cord-010119-t1x9gknd 761 8 from from IN cord-010119-t1x9gknd 761 9 1 1 CD cord-010119-t1x9gknd 761 10 IR IR NNP cord-010119-t1x9gknd 761 11 and and CC cord-010119-t1x9gknd 761 12 all all DT cord-010119-t1x9gknd 761 13 RR rr NN cord-010119-t1x9gknd 761 14 donors donor NNS cord-010119-t1x9gknd 761 15 , , , cord-010119-t1x9gknd 761 16 ranging range VBG cord-010119-t1x9gknd 761 17 from from IN cord-010119-t1x9gknd 761 18 12 12 CD cord-010119-t1x9gknd 761 19 to to IN cord-010119-t1x9gknd 761 20 2000 2000 CD cord-010119-t1x9gknd 762 1 c c NNP cord-010119-t1x9gknd 762 2 / / SYM cord-010119-t1x9gknd 762 3 mL. mL. NNP cord-010119-t1x9gknd 762 4 Study Study NNP cord-010119-t1x9gknd 762 5 Design Design NNP cord-010119-t1x9gknd 762 6 / / SYM cord-010119-t1x9gknd 762 7 Method method NN cord-010119-t1x9gknd 762 8 : : : cord-010119-t1x9gknd 762 9 Plasma plasma NN cord-010119-t1x9gknd 762 10 from from IN cord-010119-t1x9gknd 762 11 blood blood NN cord-010119-t1x9gknd 762 12 donors donor NNS cord-010119-t1x9gknd 762 13 were be VBD cord-010119-t1x9gknd 762 14 screened screen VBN cord-010119-t1x9gknd 762 15 by by IN cord-010119-t1x9gknd 762 16 individual individual JJ cord-010119-t1x9gknd 762 17 donation donation NN cord-010119-t1x9gknd 762 18 ( ( -LRB- cord-010119-t1x9gknd 762 19 ID ID NNP cord-010119-t1x9gknd 762 20 - - HYPH cord-010119-t1x9gknd 762 21 NAT NAT NNP cord-010119-t1x9gknd 762 22 ) ) -RRB- cord-010119-t1x9gknd 762 23 for for IN cord-010119-t1x9gknd 762 24 the the DT cord-010119-t1x9gknd 762 25 presence presence NN cord-010119-t1x9gknd 762 26 of of IN cord-010119-t1x9gknd 762 27 ZIKV ZIKV NNP cord-010119-t1x9gknd 762 28 RNA RNA NNP cord-010119-t1x9gknd 762 29 with with IN cord-010119-t1x9gknd 762 30 the the DT cord-010119-t1x9gknd 762 31 cobasV cobasV NNP cord-010119-t1x9gknd 762 32 R R NNP cord-010119-t1x9gknd 762 33 Zika Zika NNP cord-010119-t1x9gknd 762 34 test test NN cord-010119-t1x9gknd 762 35 . . . cord-010119-t1x9gknd 763 1 ID ID NNP cord-010119-t1x9gknd 763 2 - - HYPH cord-010119-t1x9gknd 763 3 NAT1 NAT1 NNP cord-010119-t1x9gknd 763 4 samples sample NNS cord-010119-t1x9gknd 763 5 were be VBD cord-010119-t1x9gknd 763 6 repeated repeat VBN cord-010119-t1x9gknd 763 7 in in IN cord-010119-t1x9gknd 763 8 duplicate duplicate JJ cord-010119-t1x9gknd 763 9 and and CC cord-010119-t1x9gknd 763 10 further further RB cord-010119-t1x9gknd 763 11 tested test VBN cord-010119-t1x9gknd 763 12 by by IN cord-010119-t1x9gknd 763 13 a a DT cord-010119-t1x9gknd 763 14 second second JJ cord-010119-t1x9gknd 763 15 NAT NAT NNP cord-010119-t1x9gknd 763 16 to to TO cord-010119-t1x9gknd 763 17 confirm confirm VB cord-010119-t1x9gknd 763 18 infection infection NN cord-010119-t1x9gknd 763 19 and and CC cord-010119-t1x9gknd 763 20 estimate estimate VB cord-010119-t1x9gknd 763 21 VL VL NNP cord-010119-t1x9gknd 763 22 , , , cord-010119-t1x9gknd 763 23 and and CC cord-010119-t1x9gknd 763 24 for for IN cord-010119-t1x9gknd 763 25 anti anti JJ cord-010119-t1x9gknd 763 26 - - JJ cord-010119-t1x9gknd 763 27 ZIKV zikv JJ cord-010119-t1x9gknd 763 28 IgM. IgM. NNP cord-010119-t1x9gknd 763 29 Simulated simulated JJ cord-010119-t1x9gknd 763 30 MPs MPs NNPS cord-010119-t1x9gknd 763 31 of of IN cord-010119-t1x9gknd 763 32 6 6 CD cord-010119-t1x9gknd 763 33 were be VBD cord-010119-t1x9gknd 763 34 prepared prepare VBN cord-010119-t1x9gknd 763 35 by by IN cord-010119-t1x9gknd 763 36 diluting dilute VBG cord-010119-t1x9gknd 763 37 NAT1 NAT1 NNP cord-010119-t1x9gknd 763 38 plasma plasma NN cord-010119-t1x9gknd 763 39 1:6 1:6 NN cord-010119-t1x9gknd 763 40 and and CC cord-010119-t1x9gknd 763 41 tested test VBN cord-010119-t1x9gknd 763 42 to to TO cord-010119-t1x9gknd 763 43 discriminate discriminate VB cord-010119-t1x9gknd 763 44 ID ID NNP cord-010119-t1x9gknd 763 45 - - HYPH cord-010119-t1x9gknd 763 46 NAT NAT NNP cord-010119-t1x9gknd 763 47 only only RB cord-010119-t1x9gknd 763 48 detectable detectable JJ cord-010119-t1x9gknd 763 49 donations donation NNS cord-010119-t1x9gknd 763 50 . . . cord-010119-t1x9gknd 764 1 NAT NAT NNP cord-010119-t1x9gknd 764 2 yield yield NN cord-010119-t1x9gknd 764 3 samples sample NNS cord-010119-t1x9gknd 764 4 for for IN cord-010119-t1x9gknd 764 5 which which WDT cord-010119-t1x9gknd 764 6 simulated simulate VBN cord-010119-t1x9gknd 764 7 MP MP NNP cord-010119-t1x9gknd 764 8 and and CC cord-010119-t1x9gknd 764 9 conclusive conclusive JJ cord-010119-t1x9gknd 764 10 IgM igm NN cord-010119-t1x9gknd 764 11 results result NNS cord-010119-t1x9gknd 764 12 were be VBD cord-010119-t1x9gknd 764 13 available available JJ cord-010119-t1x9gknd 764 14 ( ( -LRB- cord-010119-t1x9gknd 764 15 n5308 n5308 NNP cord-010119-t1x9gknd 764 16 ) ) -RRB- cord-010119-t1x9gknd 764 17 were be VBD cord-010119-t1x9gknd 764 18 sorted sort VBN cord-010119-t1x9gknd 764 19 into into IN cord-010119-t1x9gknd 764 20 4 4 CD cord-010119-t1x9gknd 764 21 categories category NNS cord-010119-t1x9gknd 764 22 corresponding correspond VBG cord-010119-t1x9gknd 764 23 to to IN cord-010119-t1x9gknd 764 24 sequential sequential JJ cord-010119-t1x9gknd 764 25 stages stage NNS cord-010119-t1x9gknd 764 26 of of IN cord-010119-t1x9gknd 764 27 acute acute JJ cord-010119-t1x9gknd 764 28 ZIKV ZIKV NNP cord-010119-t1x9gknd 764 29 infection infection NN cord-010119-t1x9gknd 764 30 : : : cord-010119-t1x9gknd 765 1 IgM-/low igm-/low JJ cord-010119-t1x9gknd 765 2 VL VL NNP cord-010119-t1x9gknd 765 3 ; ; : cord-010119-t1x9gknd 765 4 IgM-/high igm-/high CD cord-010119-t1x9gknd 765 5 VL VL NNP cord-010119-t1x9gknd 765 6 ; ; : cord-010119-t1x9gknd 765 7 IgM1 igm1 CC cord-010119-t1x9gknd 765 8 / / SYM cord-010119-t1x9gknd 765 9 high high JJ cord-010119-t1x9gknd 765 10 VL VL NNP cord-010119-t1x9gknd 765 11 ; ; : cord-010119-t1x9gknd 765 12 IgM1 igm1 CC cord-010119-t1x9gknd 765 13 / / SYM cord-010119-t1x9gknd 765 14 low low JJ cord-010119-t1x9gknd 765 15 VL VL NNP cord-010119-t1x9gknd 765 16 . . . cord-010119-t1x9gknd 766 1 Results result NNS cord-010119-t1x9gknd 766 2 / / SYM cord-010119-t1x9gknd 766 3 Finding finding NN cord-010119-t1x9gknd 766 4 : : : cord-010119-t1x9gknd 766 5 Of of IN cord-010119-t1x9gknd 766 6 52,942 52,942 CD cord-010119-t1x9gknd 766 7 donations donation NNS cord-010119-t1x9gknd 766 8 collected collect VBD cord-010119-t1x9gknd 766 9 April April NNP cord-010119-t1x9gknd 766 10 3-December 3-December NNP cord-010119-t1x9gknd 766 11 31 31 CD cord-010119-t1x9gknd 766 12 , , , cord-010119-t1x9gknd 766 13 352 352 CD cord-010119-t1x9gknd 766 14 were be VBD cord-010119-t1x9gknd 766 15 reactive reactive JJ cord-010119-t1x9gknd 766 16 for for IN cord-010119-t1x9gknd 766 17 ZIKV ZIKV NNP cord-010119-t1x9gknd 766 18 RNA RNA NNP cord-010119-t1x9gknd 766 19 . . . cord-010119-t1x9gknd 767 1 IgM IgM NNP cord-010119-t1x9gknd 767 2 - - HYPH cord-010119-t1x9gknd 767 3 index index NN cord-010119-t1x9gknd 767 4 donations donation NNS cord-010119-t1x9gknd 767 5 had have VBD cord-010119-t1x9gknd 767 6 higher high JJR cord-010119-t1x9gknd 767 7 VLs vl NNS cord-010119-t1x9gknd 767 8 ( ( -LRB- cord-010119-t1x9gknd 767 9 mean mean VB cord-010119-t1x9gknd 767 10 1.1 1.1 CD cord-010119-t1x9gknd 767 11 x x SYM cord-010119-t1x9gknd 767 12 10 10 CD cord-010119-t1x9gknd 767 13 6 6 CD cord-010119-t1x9gknd 767 14 vs vs IN cord-010119-t1x9gknd 767 15 8.3 8.3 CD cord-010119-t1x9gknd 767 16 x x SYM cord-010119-t1x9gknd 767 17 10 10 CD cord-010119-t1x9gknd 767 18 4 4 CD cord-010119-t1x9gknd 767 19 IU IU NNP cord-010119-t1x9gknd 767 20 / / SYM cord-010119-t1x9gknd 767 21 mL mL NNP cord-010119-t1x9gknd 767 22 ) ) -RRB- cord-010119-t1x9gknd 767 23 and and CC cord-010119-t1x9gknd 767 24 higher high JJR cord-010119-t1x9gknd 767 25 proportions proportion NNS cord-010119-t1x9gknd 767 26 of of IN cord-010119-t1x9gknd 767 27 simulated simulated JJ cord-010119-t1x9gknd 767 28 MP MP NNP cord-010119-t1x9gknd 767 29 - - HYPH cord-010119-t1x9gknd 767 30 detectable detectable JJ cord-010119-t1x9gknd 767 31 results result NNS cord-010119-t1x9gknd 767 32 ( ( -LRB- cord-010119-t1x9gknd 767 33 93 93 CD cord-010119-t1x9gknd 767 34 % % NN cord-010119-t1x9gknd 767 35 vs vs IN cord-010119-t1x9gknd 767 36 23 23 CD cord-010119-t1x9gknd 767 37 % % NN cord-010119-t1x9gknd 767 38 ) ) -RRB- cord-010119-t1x9gknd 767 39 than than IN cord-010119-t1x9gknd 767 40 IgM1 igm1 JJ cord-010119-t1x9gknd 767 41 donations donation NNS cord-010119-t1x9gknd 767 42 . . . cord-010119-t1x9gknd 768 1 The the DT cord-010119-t1x9gknd 768 2 distribution distribution NN cord-010119-t1x9gknd 768 3 by by IN cord-010119-t1x9gknd 768 4 stage stage NN cord-010119-t1x9gknd 768 5 of of IN cord-010119-t1x9gknd 768 6 infection infection NN cord-010119-t1x9gknd 768 7 was be VBD cord-010119-t1x9gknd 768 8 evaluated evaluate VBN cord-010119-t1x9gknd 768 9 as as IN cord-010119-t1x9gknd 768 10 the the DT cord-010119-t1x9gknd 768 11 epidemic epidemic NN cord-010119-t1x9gknd 768 12 evolved evolve VBD cord-010119-t1x9gknd 768 13 . . . cord-010119-t1x9gknd 769 1 Over over IN cord-010119-t1x9gknd 769 2 the the DT cord-010119-t1x9gknd 769 3 course course NN cord-010119-t1x9gknd 769 4 of of IN cord-010119-t1x9gknd 769 5 the the DT cord-010119-t1x9gknd 769 6 epidemic epidemic NN cord-010119-t1x9gknd 769 7 , , , cord-010119-t1x9gknd 769 8 the the DT cord-010119-t1x9gknd 769 9 rates rate NNS cord-010119-t1x9gknd 769 10 of of IN cord-010119-t1x9gknd 769 11 ID ID NNP cord-010119-t1x9gknd 769 12 - - HYPH cord-010119-t1x9gknd 769 13 NAT NAT NNP cord-010119-t1x9gknd 769 14 only only RB cord-010119-t1x9gknd 769 15 detectible detectible JJ cord-010119-t1x9gknd 769 16 and and CC cord-010119-t1x9gknd 769 17 IgM1 igm1 JJ cord-010119-t1x9gknd 769 18 donations donation NNS cord-010119-t1x9gknd 769 19 increased increase VBN cord-010119-t1x9gknd 769 20 ( ( -LRB- cord-010119-t1x9gknd 769 21 Table table NN cord-010119-t1x9gknd 769 22 1 1 CD cord-010119-t1x9gknd 769 23 ) ) -RRB- cord-010119-t1x9gknd 769 24 . . . cord-010119-t1x9gknd 770 1 Conclusion conclusion NN cord-010119-t1x9gknd 770 2 : : : cord-010119-t1x9gknd 771 1 This this DT cord-010119-t1x9gknd 771 2 study study NN cord-010119-t1x9gknd 771 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 771 4 how how WRB cord-010119-t1x9gknd 771 5 the the DT cord-010119-t1x9gknd 771 6 viral viral JJ cord-010119-t1x9gknd 771 7 and and CC cord-010119-t1x9gknd 771 8 immunological immunological JJ cord-010119-t1x9gknd 771 9 profiles profile NNS cord-010119-t1x9gknd 771 10 of of IN cord-010119-t1x9gknd 771 11 ZIKV ZIKV NNP cord-010119-t1x9gknd 771 12 infection infection NN cord-010119-t1x9gknd 771 13 in in IN cord-010119-t1x9gknd 771 14 the the DT cord-010119-t1x9gknd 771 15 index index NN cord-010119-t1x9gknd 771 16 donations donation NNS cord-010119-t1x9gknd 771 17 shifted shift VBD cord-010119-t1x9gknd 771 18 through through IN cord-010119-t1x9gknd 771 19 the the DT cord-010119-t1x9gknd 771 20 course course NN cord-010119-t1x9gknd 771 21 of of IN cord-010119-t1x9gknd 771 22 the the DT cord-010119-t1x9gknd 771 23 2016 2016 CD cord-010119-t1x9gknd 771 24 PR PR NNP cord-010119-t1x9gknd 771 25 epidemic epidemic NN cord-010119-t1x9gknd 771 26 . . . cord-010119-t1x9gknd 772 1 Categorization categorization NN cord-010119-t1x9gknd 772 2 of of IN cord-010119-t1x9gknd 772 3 index index NN cord-010119-t1x9gknd 772 4 samples sample NNS cord-010119-t1x9gknd 772 5 into into IN cord-010119-t1x9gknd 772 6 stages stage NNS cord-010119-t1x9gknd 772 7 of of IN cord-010119-t1x9gknd 772 8 infection infection NN cord-010119-t1x9gknd 772 9 is be VBZ cord-010119-t1x9gknd 772 10 important important JJ cord-010119-t1x9gknd 772 11 for for IN cord-010119-t1x9gknd 772 12 blood blood NN cord-010119-t1x9gknd 772 13 safety safety NN cord-010119-t1x9gknd 772 14 considerations consideration NNS cord-010119-t1x9gknd 772 15 , , , cord-010119-t1x9gknd 772 16 since since IN cord-010119-t1x9gknd 772 17 infectivity infectivity NN cord-010119-t1x9gknd 772 18 and and CC cord-010119-t1x9gknd 772 19 utility utility NN cord-010119-t1x9gknd 772 20 of of IN cord-010119-t1x9gknd 772 21 MP MP NNP cord-010119-t1x9gknd 772 22 vs vs IN cord-010119-t1x9gknd 772 23 ID ID NNP cord-010119-t1x9gknd 772 24 - - HYPH cord-010119-t1x9gknd 772 25 NAT NAT NNP cord-010119-t1x9gknd 772 26 screening screening NN cord-010119-t1x9gknd 772 27 likely likely RB cord-010119-t1x9gknd 772 28 correlate correlate VBP cord-010119-t1x9gknd 772 29 with with IN cord-010119-t1x9gknd 772 30 VL VL NNP cord-010119-t1x9gknd 772 31 and and CC cord-010119-t1x9gknd 772 32 serological serological JJ cord-010119-t1x9gknd 772 33 stages stage NNS cord-010119-t1x9gknd 772 34 of of IN cord-010119-t1x9gknd 772 35 infection infection NN cord-010119-t1x9gknd 772 36 . . . cord-010119-t1x9gknd 773 1 Staging staging NN cord-010119-t1x9gknd 773 2 of of IN cord-010119-t1x9gknd 773 3 infections infection NNS cord-010119-t1x9gknd 773 4 also also RB cord-010119-t1x9gknd 773 5 has have VBZ cord-010119-t1x9gknd 773 6 implications implication NNS cord-010119-t1x9gknd 773 7 for for IN cord-010119-t1x9gknd 773 8 diagnostic diagnostic JJ cord-010119-t1x9gknd 773 9 testing testing NN cord-010119-t1x9gknd 773 10 and and CC cord-010119-t1x9gknd 773 11 understanding understand VBG cord-010119-t1x9gknd 773 12 the the DT cord-010119-t1x9gknd 773 13 durations duration NNS cord-010119-t1x9gknd 773 14 of of IN cord-010119-t1x9gknd 773 15 ZIKV ZIKV NNP cord-010119-t1x9gknd 773 16 viral viral JJ cord-010119-t1x9gknd 773 17 and and CC cord-010119-t1x9gknd 773 18 immunological immunological JJ cord-010119-t1x9gknd 773 19 markers marker NNS cord-010119-t1x9gknd 773 20 in in IN cord-010119-t1x9gknd 773 21 blood blood NN cord-010119-t1x9gknd 773 22 and and CC cord-010119-t1x9gknd 773 23 persistence persistence NN cord-010119-t1x9gknd 773 24 of of IN cord-010119-t1x9gknd 773 25 ZIKV ZIKV NNP cord-010119-t1x9gknd 773 26 in in IN cord-010119-t1x9gknd 773 27 body body NN cord-010119-t1x9gknd 773 28 fluids fluid NNS cord-010119-t1x9gknd 773 29 and and CC cord-010119-t1x9gknd 773 30 tissues tissue NNS cord-010119-t1x9gknd 773 31 . . . cord-010119-t1x9gknd 774 1 cobasV cobasv CC cord-010119-t1x9gknd 774 2 R R NNP cord-010119-t1x9gknd 774 3 Zika Zika NNP cord-010119-t1x9gknd 774 4 is be VBZ cord-010119-t1x9gknd 774 5 not not RB cord-010119-t1x9gknd 774 6 commercially commercially RB cord-010119-t1x9gknd 774 7 available available JJ cord-010119-t1x9gknd 774 8 for for IN cord-010119-t1x9gknd 774 9 blood blood NN cord-010119-t1x9gknd 774 10 screening screening NN cord-010119-t1x9gknd 774 11 . . . cord-010119-t1x9gknd 775 1 Data datum NNS cord-010119-t1x9gknd 775 2 generated generate VBN cord-010119-t1x9gknd 775 3 under under IN cord-010119-t1x9gknd 775 4 the the DT cord-010119-t1x9gknd 775 5 cobasV cobasV NNP cord-010119-t1x9gknd 775 6 R R NNP cord-010119-t1x9gknd 775 7 Zika Zika NNP cord-010119-t1x9gknd 775 8 IND IND NNP cord-010119-t1x9gknd 775 9 is be VBZ cord-010119-t1x9gknd 775 10 preliminary preliminary JJ cord-010119-t1x9gknd 775 11 and and CC cord-010119-t1x9gknd 775 12 has have VBZ cord-010119-t1x9gknd 775 13 not not RB cord-010119-t1x9gknd 775 14 been be VBN cord-010119-t1x9gknd 775 15 reviewed review VBN cord-010119-t1x9gknd 775 16 by by IN cord-010119-t1x9gknd 775 17 FDA FDA NNP cord-010119-t1x9gknd 775 18 . . . cord-010119-t1x9gknd 776 1 This this DT cord-010119-t1x9gknd 776 2 project project NN cord-010119-t1x9gknd 776 3 has have VBZ cord-010119-t1x9gknd 776 4 been be VBN cord-010119-t1x9gknd 776 5 funded fund VBN cord-010119-t1x9gknd 776 6 in in IN cord-010119-t1x9gknd 776 7 whole whole JJ cord-010119-t1x9gknd 776 8 or or CC cord-010119-t1x9gknd 776 9 in in IN cord-010119-t1x9gknd 776 10 part part NN cord-010119-t1x9gknd 776 11 with with IN cord-010119-t1x9gknd 776 12 Federal Federal NNP cord-010119-t1x9gknd 776 13 funds fund NNS cord-010119-t1x9gknd 776 14 _SP cord-010119-t1x9gknd 776 15 Detection Detection NNP cord-010119-t1x9gknd 776 16 of of IN cord-010119-t1x9gknd 776 17 Zika Zika NNP cord-010119-t1x9gknd 776 18 Virus Virus NNP cord-010119-t1x9gknd 776 19 RNA RNA NNP cord-010119-t1x9gknd 776 20 in in IN cord-010119-t1x9gknd 776 21 United United NNP cord-010119-t1x9gknd 776 22 States States NNP cord-010119-t1x9gknd 776 23 Blood Blood NNP cord-010119-t1x9gknd 776 24 Donations donation NNS cord-010119-t1x9gknd 777 1 Using use VBG cord-010119-t1x9gknd 777 2 cobas cobas NNP cord-010119-t1x9gknd 777 3 V V NNP cord-010119-t1x9gknd 777 4 R R NNP cord-010119-t1x9gknd 777 5 Zika Zika NNP cord-010119-t1x9gknd 777 6 on on IN cord-010119-t1x9gknd 777 7 the the DT cord-010119-t1x9gknd 777 8 cobas cobas NN cord-010119-t1x9gknd 777 9 V v NN cord-010119-t1x9gknd 777 10 R r NN cord-010119-t1x9gknd 777 11 6800/8800 6800/8800 CD cord-010119-t1x9gknd 778 1 Systems Systems NNPS cord-010119-t1x9gknd 778 2 Lisa Lisa NNP cord-010119-t1x9gknd 778 3 Lee Lee NNP cord-010119-t1x9gknd 778 4 Pate Pate NNP cord-010119-t1x9gknd 779 1 * * NFP cord-010119-t1x9gknd 779 2 1 1 CD cord-010119-t1x9gknd 779 3 , , , cord-010119-t1x9gknd 779 4 Phillip Phillip NNP cord-010119-t1x9gknd 779 5 C C NNP cord-010119-t1x9gknd 779 6 Williamson Williamson NNP cord-010119-t1x9gknd 779 7 2 2 CD cord-010119-t1x9gknd 779 8 , , , cord-010119-t1x9gknd 779 9 Michael Michael NNP cord-010119-t1x9gknd 779 10 Paul Paul NNP cord-010119-t1x9gknd 779 11 Busch Busch NNP cord-010119-t1x9gknd 779 12 3 3 CD cord-010119-t1x9gknd 779 13 , , , cord-010119-t1x9gknd 779 14 Susan Susan NNP cord-010119-t1x9gknd 779 15 Rossmann Rossmann NNP cord-010119-t1x9gknd 779 16 4 4 CD cord-010119-t1x9gknd 779 17 , , , cord-010119-t1x9gknd 779 18 Scott Scott NNP cord-010119-t1x9gknd 779 19 Jones Jones NNP cord-010119-t1x9gknd 779 20 5 5 CD cord-010119-t1x9gknd 779 21 , , , cord-010119-t1x9gknd 779 22 Ann Ann NNP cord-010119-t1x9gknd 779 23 Butcher Butcher NNP cord-010119-t1x9gknd 779 24 1 1 CD cord-010119-t1x9gknd 779 25 , , , cord-010119-t1x9gknd 779 26 John John NNP cord-010119-t1x9gknd 779 27 Duncan Duncan NNP cord-010119-t1x9gknd 779 28 1 1 CD cord-010119-t1x9gknd 779 29 , , , cord-010119-t1x9gknd 779 30 Jean Jean NNP cord-010119-t1x9gknd 779 31 Stanley Stanley NNP cord-010119-t1x9gknd 779 32 1 1 CD cord-010119-t1x9gknd 779 33 and and CC cord-010119-t1x9gknd 779 34 Susan Susan NNP cord-010119-t1x9gknd 779 35 A A NNP cord-010119-t1x9gknd 779 36 Galel Galel NNP cord-010119-t1x9gknd 779 37 1 1 CD cord-010119-t1x9gknd 779 38 . . . cord-010119-t1x9gknd 780 1 1 1 LS cord-010119-t1x9gknd 781 1 Roche Roche NNP cord-010119-t1x9gknd 781 2 Molecular Molecular NNP cord-010119-t1x9gknd 781 3 Systems Systems NNP cord-010119-t1x9gknd 781 4 , , , cord-010119-t1x9gknd 781 5 Inc. Inc. NNP cord-010119-t1x9gknd 781 6 , , , cord-010119-t1x9gknd 781 7 2 2 CD cord-010119-t1x9gknd 781 8 Creative Creative NNP cord-010119-t1x9gknd 781 9 Testing Testing NNP cord-010119-t1x9gknd 781 10 Solutions Solutions NNPS cord-010119-t1x9gknd 781 11 , , , cord-010119-t1x9gknd 781 12 3 3 CD cord-010119-t1x9gknd 781 13 Blood Blood NNP cord-010119-t1x9gknd 781 14 Systems Systems NNPS cord-010119-t1x9gknd 781 15 Research Research NNP cord-010119-t1x9gknd 781 16 Institute Institute NNP cord-010119-t1x9gknd 781 17 , , , cord-010119-t1x9gknd 781 18 4 4 CD cord-010119-t1x9gknd 781 19 Gulf Gulf NNP cord-010119-t1x9gknd 781 20 Coast Coast NNP cord-010119-t1x9gknd 781 21 Regional Regional NNP cord-010119-t1x9gknd 781 22 Blood Blood NNP cord-010119-t1x9gknd 781 23 Center Center NNP cord-010119-t1x9gknd 781 24 -Sugar -Sugar NNP cord-010119-t1x9gknd 781 25 Land Land NNP cord-010119-t1x9gknd 781 26 , , , cord-010119-t1x9gknd 781 27 5 5 CD cord-010119-t1x9gknd 781 28 QualTex QualTex NNP cord-010119-t1x9gknd 781 29 Laboratories Laboratories NNPS cord-010119-t1x9gknd 781 30 Background Background NNP cord-010119-t1x9gknd 781 31 / / SYM cord-010119-t1x9gknd 781 32 Case Case NNP cord-010119-t1x9gknd 781 33 Studies Studies NNPS cord-010119-t1x9gknd 781 34 : : : cord-010119-t1x9gknd 782 1 In in IN cord-010119-t1x9gknd 782 2 February February NNP cord-010119-t1x9gknd 782 3 2016 2016 CD cord-010119-t1x9gknd 782 4 , , , cord-010119-t1x9gknd 782 5 the the DT cord-010119-t1x9gknd 782 6 US US NNP cord-010119-t1x9gknd 782 7 FDA FDA NNP cord-010119-t1x9gknd 782 8 recommended recommend VBD cord-010119-t1x9gknd 782 9 that that IN cord-010119-t1x9gknd 782 10 all all DT cord-010119-t1x9gknd 782 11 blood blood NN cord-010119-t1x9gknd 782 12 donations donation NNS cord-010119-t1x9gknd 782 13 in in IN cord-010119-t1x9gknd 782 14 areas area NNS cord-010119-t1x9gknd 782 15 with with IN cord-010119-t1x9gknd 782 16 active active JJ cord-010119-t1x9gknd 782 17 Zika Zika NNP cord-010119-t1x9gknd 782 18 virus virus NN cord-010119-t1x9gknd 782 19 ( ( -LRB- cord-010119-t1x9gknd 782 20 ZIKV ZIKV NNP cord-010119-t1x9gknd 782 21 ) ) -RRB- cord-010119-t1x9gknd 782 22 transmission transmission NN cord-010119-t1x9gknd 782 23 be be VB cord-010119-t1x9gknd 782 24 tested test VBN cord-010119-t1x9gknd 782 25 with with IN cord-010119-t1x9gknd 782 26 an an DT cord-010119-t1x9gknd 782 27 FDA FDA NNP cord-010119-t1x9gknd 782 28 approved approve VBN cord-010119-t1x9gknd 782 29 nucleic nucleic JJ cord-010119-t1x9gknd 782 30 acid acid NN cord-010119-t1x9gknd 782 31 test test NN cord-010119-t1x9gknd 782 32 ( ( -LRB- cord-010119-t1x9gknd 782 33 NAT NAT NNP cord-010119-t1x9gknd 782 34 ) ) -RRB- cord-010119-t1x9gknd 782 35 for for IN cord-010119-t1x9gknd 782 36 ZIKV ZIKV NNP cord-010119-t1x9gknd 782 37 RNA RNA NNP cord-010119-t1x9gknd 782 38 or or CC cord-010119-t1x9gknd 782 39 treated treat VBN cord-010119-t1x9gknd 782 40 with with IN cord-010119-t1x9gknd 782 41 an an DT cord-010119-t1x9gknd 782 42 FDA FDA NNP cord-010119-t1x9gknd 782 43 approved approve VBD cord-010119-t1x9gknd 782 44 pathogen pathogen NN cord-010119-t1x9gknd 782 45 reduction reduction NN cord-010119-t1x9gknd 782 46 technology technology NN cord-010119-t1x9gknd 782 47 . . . cord-010119-t1x9gknd 783 1 The the DT cord-010119-t1x9gknd 783 2 cobasV cobasV NNP cord-010119-t1x9gknd 783 3 R R NNP cord-010119-t1x9gknd 783 4 Zika Zika NNP cord-010119-t1x9gknd 783 5 test test NN cord-010119-t1x9gknd 783 6 was be VBD cord-010119-t1x9gknd 783 7 approved approve VBN cord-010119-t1x9gknd 783 8 under under IN cord-010119-t1x9gknd 783 9 an an DT cord-010119-t1x9gknd 783 10 investigational investigational JJ cord-010119-t1x9gknd 783 11 new new JJ cord-010119-t1x9gknd 783 12 drug drug NN cord-010119-t1x9gknd 783 13 application application NN cord-010119-t1x9gknd 783 14 on on IN cord-010119-t1x9gknd 783 15 March March NNP cord-010119-t1x9gknd 783 16 30 30 CD cord-010119-t1x9gknd 783 17 , , , cord-010119-t1x9gknd 783 18 2016 2016 CD cord-010119-t1x9gknd 783 19 and and CC cord-010119-t1x9gknd 783 20 testing testing NN cord-010119-t1x9gknd 783 21 of of IN cord-010119-t1x9gknd 783 22 Puerto Puerto NNP cord-010119-t1x9gknd 783 23 Rico Rico NNP cord-010119-t1x9gknd 783 24 donations donation NNS cord-010119-t1x9gknd 783 25 began begin VBD cord-010119-t1x9gknd 783 26 on on IN cord-010119-t1x9gknd 783 27 April April NNP cord-010119-t1x9gknd 783 28 3 3 CD cord-010119-t1x9gknd 783 29 , , , cord-010119-t1x9gknd 783 30 2016 2016 CD cord-010119-t1x9gknd 783 31 . . . cord-010119-t1x9gknd 784 1 As as IN cord-010119-t1x9gknd 784 2 a a DT cord-010119-t1x9gknd 784 3 precautionary precautionary JJ cord-010119-t1x9gknd 784 4 measure measure NN cord-010119-t1x9gknd 784 5 some some DT cord-010119-t1x9gknd 784 6 blood blood NN cord-010119-t1x9gknd 784 7 centers center NNS cord-010119-t1x9gknd 784 8 in in IN cord-010119-t1x9gknd 784 9 the the DT cord-010119-t1x9gknd 784 10 US US NNP cord-010119-t1x9gknd 784 11 states state NNS cord-010119-t1x9gknd 784 12 also also RB cord-010119-t1x9gknd 784 13 began begin VBD cord-010119-t1x9gknd 784 14 NAT NAT NNP cord-010119-t1x9gknd 784 15 testing testing NN cord-010119-t1x9gknd 784 16 for for IN cord-010119-t1x9gknd 784 17 ZIKV ZIKV NNP cord-010119-t1x9gknd 784 18 . . . cord-010119-t1x9gknd 785 1 In in IN cord-010119-t1x9gknd 785 2 August August NNP cord-010119-t1x9gknd 785 3 2016 2016 CD cord-010119-t1x9gknd 785 4 , , , cord-010119-t1x9gknd 785 5 the the DT cord-010119-t1x9gknd 785 6 FDA FDA NNP cord-010119-t1x9gknd 785 7 recommended recommend VBD cord-010119-t1x9gknd 785 8 universal universal JJ cord-010119-t1x9gknd 785 9 screening screening NN cord-010119-t1x9gknd 785 10 of of IN cord-010119-t1x9gknd 785 11 all all DT cord-010119-t1x9gknd 785 12 blood blood NN cord-010119-t1x9gknd 785 13 donations donation NNS cord-010119-t1x9gknd 785 14 . . . cord-010119-t1x9gknd 786 1 The the DT cord-010119-t1x9gknd 786 2 aim aim NN cord-010119-t1x9gknd 786 3 of of IN cord-010119-t1x9gknd 786 4 this this DT cord-010119-t1x9gknd 786 5 study study NN cord-010119-t1x9gknd 786 6 is be VBZ cord-010119-t1x9gknd 786 7 to to TO cord-010119-t1x9gknd 786 8 describe describe VB cord-010119-t1x9gknd 786 9 the the DT cord-010119-t1x9gknd 786 10 detection detection NN cord-010119-t1x9gknd 786 11 of of IN cord-010119-t1x9gknd 786 12 ZIKV ZIKV NNP cord-010119-t1x9gknd 786 13 RNA RNA NNP cord-010119-t1x9gknd 786 14 in in IN cord-010119-t1x9gknd 786 15 blood blood NN cord-010119-t1x9gknd 786 16 donations donation NNS cord-010119-t1x9gknd 786 17 collected collect VBN cord-010119-t1x9gknd 786 18 in in IN cord-010119-t1x9gknd 786 19 US US NNP cord-010119-t1x9gknd 786 20 states state NNS cord-010119-t1x9gknd 786 21 between between IN cord-010119-t1x9gknd 786 22 April April NNP cord-010119-t1x9gknd 786 23 3 3 CD cord-010119-t1x9gknd 786 24 , , , cord-010119-t1x9gknd 786 25 2016 2016 CD cord-010119-t1x9gknd 786 26 -February -february SYM cord-010119-t1x9gknd 786 27 28 28 CD cord-010119-t1x9gknd 786 28 , , , cord-010119-t1x9gknd 786 29 2017 2017 CD cord-010119-t1x9gknd 786 30 using use VBG cord-010119-t1x9gknd 786 31 the the DT cord-010119-t1x9gknd 786 32 investigational investigational JJ cord-010119-t1x9gknd 786 33 cobasV cobasv CC cord-010119-t1x9gknd 786 34 R R NNP cord-010119-t1x9gknd 786 35 Zika Zika NNP cord-010119-t1x9gknd 786 36 for for IN cord-010119-t1x9gknd 786 37 use use NN cord-010119-t1x9gknd 786 38 on on IN cord-010119-t1x9gknd 786 39 the the DT cord-010119-t1x9gknd 786 40 cobas cobas NN cord-010119-t1x9gknd 786 41 V v NN cord-010119-t1x9gknd 786 42 R R NNP cord-010119-t1x9gknd 786 43 6800/8800 6800/8800 CD cord-010119-t1x9gknd 786 44 Systems Systems NNPS cord-010119-t1x9gknd 786 45 . . . cord-010119-t1x9gknd 787 1 Study Study NNP cord-010119-t1x9gknd 787 2 Design Design NNP cord-010119-t1x9gknd 787 3 / / SYM cord-010119-t1x9gknd 787 4 Methods method NNS cord-010119-t1x9gknd 787 5 : : : cord-010119-t1x9gknd 787 6 Donations donation NNS cord-010119-t1x9gknd 787 7 were be VBD cord-010119-t1x9gknd 787 8 screened screen VBN cord-010119-t1x9gknd 787 9 with with IN cord-010119-t1x9gknd 787 10 cobasV cobasv CC cord-010119-t1x9gknd 787 11 R R NNP cord-010119-t1x9gknd 787 12 Zika Zika NNP cord-010119-t1x9gknd 787 13 by by IN cord-010119-t1x9gknd 787 14 individual individual JJ cord-010119-t1x9gknd 787 15 donation donation NN cord-010119-t1x9gknd 787 16 testing testing NN cord-010119-t1x9gknd 787 17 . . . cord-010119-t1x9gknd 788 1 All all DT cord-010119-t1x9gknd 788 2 initial initial JJ cord-010119-t1x9gknd 788 3 reactive reactive JJ cord-010119-t1x9gknd 788 4 ( ( -LRB- cord-010119-t1x9gknd 788 5 IR IR NNP cord-010119-t1x9gknd 788 6 ) ) -RRB- cord-010119-t1x9gknd 788 7 results result NNS cord-010119-t1x9gknd 788 8 were be VBD cord-010119-t1x9gknd 788 9 repeated repeat VBN cord-010119-t1x9gknd 788 10 in in IN cord-010119-t1x9gknd 788 11 duplicate duplicate NN cord-010119-t1x9gknd 788 12 . . . cord-010119-t1x9gknd 789 1 Supplemental supplemental JJ cord-010119-t1x9gknd 789 2 testing testing NN cord-010119-t1x9gknd 789 3 included include VBD cord-010119-t1x9gknd 789 4 an an DT cord-010119-t1x9gknd 789 5 alternative alternative JJ cord-010119-t1x9gknd 789 6 NAT NAT NNP cord-010119-t1x9gknd 789 7 ( ( -LRB- cord-010119-t1x9gknd 789 8 AltNAT altnat NN cord-010119-t1x9gknd 789 9 ) ) -RRB- cord-010119-t1x9gknd 789 10 assay assay NN cord-010119-t1x9gknd 789 11 which which WDT cord-010119-t1x9gknd 789 12 is be VBZ cord-010119-t1x9gknd 789 13 less less RBR cord-010119-t1x9gknd 789 14 sensitive sensitive JJ cord-010119-t1x9gknd 789 15 than than IN cord-010119-t1x9gknd 789 16 cobasV cobasv CC cord-010119-t1x9gknd 789 17 R R NNP cord-010119-t1x9gknd 789 18 Zika Zika NNP cord-010119-t1x9gknd 789 19 and and CC cord-010119-t1x9gknd 789 20 serology serology NN cord-010119-t1x9gknd 789 21 testing testing NN cord-010119-t1x9gknd 789 22 for for IN cord-010119-t1x9gknd 790 1 anti anti JJ cord-010119-t1x9gknd 790 2 - - JJ cord-010119-t1x9gknd 790 3 Zika zika JJ cord-010119-t1x9gknd 790 4 IgM igm NN cord-010119-t1x9gknd 790 5 and and CC cord-010119-t1x9gknd 790 6 IgG. IgG. NNP cord-010119-t1x9gknd 790 7 Reactive Reactive NNP cord-010119-t1x9gknd 790 8 donors donor NNS cord-010119-t1x9gknd 790 9 were be VBD cord-010119-t1x9gknd 790 10 invited invite VBN cord-010119-t1x9gknd 790 11 to to TO cord-010119-t1x9gknd 790 12 enroll enroll VB cord-010119-t1x9gknd 790 13 in in IN cord-010119-t1x9gknd 790 14 follow follow NN cord-010119-t1x9gknd 790 15 - - HYPH cord-010119-t1x9gknd 790 16 up up NN cord-010119-t1x9gknd 790 17 , , , cord-010119-t1x9gknd 790 18 which which WDT cord-010119-t1x9gknd 790 19 included include VBD cord-010119-t1x9gknd 790 20 cobasV cobasv CC cord-010119-t1x9gknd 790 21 R R NNP cord-010119-t1x9gknd 790 22 Zika Zika NNP cord-010119-t1x9gknd 790 23 and and CC cord-010119-t1x9gknd 790 24 serology serology NN cord-010119-t1x9gknd 790 25 testing testing NN cord-010119-t1x9gknd 790 26 . . . cord-010119-t1x9gknd 791 1 A a DT cord-010119-t1x9gknd 791 2 donor donor NN cord-010119-t1x9gknd 791 3 was be VBD cord-010119-t1x9gknd 791 4 considered consider VBN cord-010119-t1x9gknd 791 5 to to TO cord-010119-t1x9gknd 791 6 be be VB cord-010119-t1x9gknd 791 7 Zika Zika NNP cord-010119-t1x9gknd 791 8 confirmed confirm VBD cord-010119-t1x9gknd 791 9 positive positive JJ cord-010119-t1x9gknd 792 1 if if IN cord-010119-t1x9gknd 792 2 at at RB cord-010119-t1x9gknd 792 3 least least RBS cord-010119-t1x9gknd 792 4 one one CD cord-010119-t1x9gknd 792 5 replicate replicate NN cord-010119-t1x9gknd 792 6 of of IN cord-010119-t1x9gknd 792 7 the the DT cord-010119-t1x9gknd 792 8 repeat repeat NN cord-010119-t1x9gknd 792 9 testing testing NN cord-010119-t1x9gknd 792 10 by by IN cord-010119-t1x9gknd 792 11 cobasV cobasv CC cord-010119-t1x9gknd 792 12 R R NNP cord-010119-t1x9gknd 792 13 Zika Zika NNP cord-010119-t1x9gknd 792 14 was be VBD cord-010119-t1x9gknd 792 15 reactive reactive JJ cord-010119-t1x9gknd 792 16 on on IN cord-010119-t1x9gknd 792 17 index index NN cord-010119-t1x9gknd 792 18 donation donation NN cord-010119-t1x9gknd 792 19 or or CC cord-010119-t1x9gknd 792 20 follow follow NN cord-010119-t1x9gknd 792 21 - - HYPH cord-010119-t1x9gknd 792 22 up up NN cord-010119-t1x9gknd 792 23 , , , cord-010119-t1x9gknd 792 24 reactive reactive JJ cord-010119-t1x9gknd 792 25 by by IN cord-010119-t1x9gknd 792 26 AltNAT AltNAT NNP cord-010119-t1x9gknd 792 27 on on IN cord-010119-t1x9gknd 792 28 the the DT cord-010119-t1x9gknd 792 29 index index NN cord-010119-t1x9gknd 792 30 donation donation NN cord-010119-t1x9gknd 792 31 , , , cord-010119-t1x9gknd 792 32 or or CC cord-010119-t1x9gknd 792 33 positive positive JJ cord-010119-t1x9gknd 792 34 for for IN cord-010119-t1x9gknd 792 35 anti anti JJ cord-010119-t1x9gknd 792 36 - - JJ cord-010119-t1x9gknd 792 37 Zika zika JJ cord-010119-t1x9gknd 792 38 IgM igm NN cord-010119-t1x9gknd 792 39 on on IN cord-010119-t1x9gknd 792 40 index index NN cord-010119-t1x9gknd 792 41 or or CC cord-010119-t1x9gknd 792 42 follow follow NN cord-010119-t1x9gknd 792 43 - - HYPH cord-010119-t1x9gknd 792 44 up up NN cord-010119-t1x9gknd 792 45 . . . cord-010119-t1x9gknd 793 1 All all DT cord-010119-t1x9gknd 793 2 IR IR NNP cord-010119-t1x9gknd 793 3 donations donation NNS cord-010119-t1x9gknd 793 4 were be VBD cord-010119-t1x9gknd 793 5 also also RB cord-010119-t1x9gknd 793 6 retested reteste VBN cord-010119-t1x9gknd 793 7 at at IN cord-010119-t1x9gknd 793 8 a a DT cord-010119-t1x9gknd 793 9 1:6 1:6 CD cord-010119-t1x9gknd 793 10 dilution dilution NN cord-010119-t1x9gknd 793 11 to to TO cord-010119-t1x9gknd 793 12 simulate simulate VB cord-010119-t1x9gknd 793 13 mini mini JJ cord-010119-t1x9gknd 793 14 - - JJ cord-010119-t1x9gknd 793 15 pool pool JJ cord-010119-t1x9gknd 793 16 testing testing NN cord-010119-t1x9gknd 793 17 . . . cord-010119-t1x9gknd 794 1 Results result NNS cord-010119-t1x9gknd 794 2 / / SYM cord-010119-t1x9gknd 794 3 Findings finding NNS cord-010119-t1x9gknd 794 4 : : : cord-010119-t1x9gknd 795 1 A a DT cord-010119-t1x9gknd 795 2 total total NN cord-010119-t1x9gknd 795 3 of of IN cord-010119-t1x9gknd 795 4 1,776,190 1,776,190 CD cord-010119-t1x9gknd 795 5 blood blood NN cord-010119-t1x9gknd 795 6 donations donation NNS cord-010119-t1x9gknd 795 7 were be VBD cord-010119-t1x9gknd 795 8 screened screen VBN cord-010119-t1x9gknd 795 9 using use VBG cord-010119-t1x9gknd 795 10 cobasV cobasV NNP cord-010119-t1x9gknd 795 11 R R NNP cord-010119-t1x9gknd 795 12 Zika Zika NNP cord-010119-t1x9gknd 795 13 . . . cord-010119-t1x9gknd 796 1 Of of IN cord-010119-t1x9gknd 796 2 56 56 CD cord-010119-t1x9gknd 796 3 IR IR NNP cord-010119-t1x9gknd 796 4 donations donation NNS cord-010119-t1x9gknd 796 5 , , , cord-010119-t1x9gknd 796 6 12 12 CD cord-010119-t1x9gknd 796 7 were be VBD cord-010119-t1x9gknd 796 8 repeat repeat NN cord-010119-t1x9gknd 796 9 reactive reactive JJ cord-010119-t1x9gknd 796 10 ( ( -LRB- cord-010119-t1x9gknd 796 11 RR RR NNP cord-010119-t1x9gknd 796 12 ) ) -RRB- cord-010119-t1x9gknd 796 13 , , , cord-010119-t1x9gknd 796 14 39 39 CD cord-010119-t1x9gknd 796 15 non non JJ cord-010119-t1x9gknd 796 16 - - JJ cord-010119-t1x9gknd 796 17 RR rr NN cord-010119-t1x9gknd 796 18 and and CC cord-010119-t1x9gknd 796 19 5 5 CD cord-010119-t1x9gknd 796 20 had have VBD cord-010119-t1x9gknd 796 21 no no DT cord-010119-t1x9gknd 796 22 repeat repeat NN cord-010119-t1x9gknd 796 23 testing testing NN cord-010119-t1x9gknd 796 24 . . . cord-010119-t1x9gknd 797 1 Of of IN cord-010119-t1x9gknd 797 2 the the DT cord-010119-t1x9gknd 797 3 12 12 CD cord-010119-t1x9gknd 797 4 RR RR NNP cord-010119-t1x9gknd 797 5 donations donation NNS cord-010119-t1x9gknd 797 6 , , , cord-010119-t1x9gknd 797 7 7 7 CD cord-010119-t1x9gknd 797 8 were be VBD cord-010119-t1x9gknd 797 9 positive positive JJ cord-010119-t1x9gknd 797 10 by by IN cord-010119-t1x9gknd 797 11 AltNAT AltNAT NNP cord-010119-t1x9gknd 797 12 ; ; : cord-010119-t1x9gknd 797 13 3 3 CD cord-010119-t1x9gknd 797 14 of of IN cord-010119-t1x9gknd 797 15 these these DT cord-010119-t1x9gknd 797 16 were be VBD cord-010119-t1x9gknd 797 17 IgM IgM NNP cord-010119-t1x9gknd 797 18 positive positive JJ cord-010119-t1x9gknd 797 19 . . . cord-010119-t1x9gknd 798 1 All all DT cord-010119-t1x9gknd 798 2 4 4 CD cord-010119-t1x9gknd 798 3 AltNAT altnat VBP cord-010119-t1x9gknd 798 4 negative negative JJ cord-010119-t1x9gknd 798 5 donors donor NNS cord-010119-t1x9gknd 798 6 were be VBD cord-010119-t1x9gknd 798 7 IgM IgM NNP cord-010119-t1x9gknd 798 8 positive positive JJ cord-010119-t1x9gknd 798 9 . . . cord-010119-t1x9gknd 799 1 One one CD cord-010119-t1x9gknd 799 2 donor donor NN cord-010119-t1x9gknd 799 3 was be VBD cord-010119-t1x9gknd 799 4 Alt Alt NNP cord-010119-t1x9gknd 799 5 - - HYPH cord-010119-t1x9gknd 799 6 NAT NAT NNP cord-010119-t1x9gknd 799 7 equivocal equivocal JJ cord-010119-t1x9gknd 799 8 and and CC cord-010119-t1x9gknd 799 9 IgM IgM NNP cord-010119-t1x9gknd 799 10 negative negative JJ cord-010119-t1x9gknd 799 11 . . . cord-010119-t1x9gknd 800 1 Of of IN cord-010119-t1x9gknd 800 2 the the DT cord-010119-t1x9gknd 800 3 5 5 CD cord-010119-t1x9gknd 800 4 RR rr NN cord-010119-t1x9gknd 800 5 donors donor NNS cord-010119-t1x9gknd 800 6 that that WDT cord-010119-t1x9gknd 800 7 were be VBD cord-010119-t1x9gknd 800 8 not not RB cord-010119-t1x9gknd 800 9 IgM IgM NNP cord-010119-t1x9gknd 800 10 positive positive JJ cord-010119-t1x9gknd 800 11 on on IN cord-010119-t1x9gknd 800 12 index index NN cord-010119-t1x9gknd 800 13 , , , cord-010119-t1x9gknd 800 14 3 3 CD cord-010119-t1x9gknd 800 15 enrolled enrol VBD cord-010119-t1x9gknd 800 16 in in IN cord-010119-t1x9gknd 800 17 follow follow NN cord-010119-t1x9gknd 800 18 - - HYPH cord-010119-t1x9gknd 800 19 up up NN cord-010119-t1x9gknd 800 20 and and CC cord-010119-t1x9gknd 800 21 all all DT cord-010119-t1x9gknd 800 22 seroconverted seroconverte VBD cord-010119-t1x9gknd 800 23 . . . cord-010119-t1x9gknd 801 1 Of of IN cord-010119-t1x9gknd 801 2 39 39 CD cord-010119-t1x9gknd 801 3 non non JJ cord-010119-t1x9gknd 801 4 - - JJ cord-010119-t1x9gknd 801 5 RR rr JJ cord-010119-t1x9gknd 801 6 donations donation NNS cord-010119-t1x9gknd 801 7 , , , cord-010119-t1x9gknd 801 8 38 38 CD cord-010119-t1x9gknd 801 9 were be VBD cord-010119-t1x9gknd 801 10 AltNAT AltNAT VBN cord-010119-t1x9gknd 801 11 negative negative JJ cord-010119-t1x9gknd 801 12 and and CC cord-010119-t1x9gknd 801 13 1 1 CD cord-010119-t1x9gknd 801 14 is be VBZ cord-010119-t1x9gknd 801 15 pending pende VBG cord-010119-t1x9gknd 801 16 supplemental supplemental JJ cord-010119-t1x9gknd 801 17 testing testing NN cord-010119-t1x9gknd 801 18 . . . cord-010119-t1x9gknd 802 1 8/38 8/38 CD cord-010119-t1x9gknd 802 2 donors donor NNS cord-010119-t1x9gknd 802 3 were be VBD cord-010119-t1x9gknd 802 4 IgM IgM NNP cord-010119-t1x9gknd 802 5 positive positive JJ cord-010119-t1x9gknd 802 6 on on IN cord-010119-t1x9gknd 802 7 index index NN cord-010119-t1x9gknd 802 8 . . . cord-010119-t1x9gknd 803 1 30 30 CD cord-010119-t1x9gknd 803 2 donors donor NNS cord-010119-t1x9gknd 803 3 were be VBD cord-010119-t1x9gknd 803 4 IgM IgM NNP cord-010119-t1x9gknd 803 5 negative negative JJ cord-010119-t1x9gknd 803 6 on on IN cord-010119-t1x9gknd 803 7 index index NN cord-010119-t1x9gknd 803 8 ; ; : cord-010119-t1x9gknd 803 9 15/30 15/30 CD cord-010119-t1x9gknd 803 10 enrolled enrol VBN cord-010119-t1x9gknd 803 11 in in IN cord-010119-t1x9gknd 803 12 follow follow NN cord-010119-t1x9gknd 803 13 - - HYPH cord-010119-t1x9gknd 803 14 up up NN cord-010119-t1x9gknd 803 15 ; ; : cord-010119-t1x9gknd 803 16 14 14 CD cord-010119-t1x9gknd 803 17 remained remain VBD cord-010119-t1x9gknd 803 18 IgM IgM NNP cord-010119-t1x9gknd 803 19 negative negative NNP cord-010119-t1x9gknd 803 20 and and CC cord-010119-t1x9gknd 803 21 1 1 CD cord-010119-t1x9gknd 803 22 was be VBD cord-010119-t1x9gknd 803 23 1gM 1gm CD cord-010119-t1x9gknd 803 24 inconclusive inconclusive JJ cord-010119-t1x9gknd 803 25 . . . cord-010119-t1x9gknd 804 1 Of of IN cord-010119-t1x9gknd 804 2 5 5 CD cord-010119-t1x9gknd 804 3 donations donation NNS cord-010119-t1x9gknd 804 4 without without IN cord-010119-t1x9gknd 804 5 repeat repeat NN cord-010119-t1x9gknd 804 6 testing testing NN cord-010119-t1x9gknd 804 7 results result NNS cord-010119-t1x9gknd 804 8 , , , cord-010119-t1x9gknd 804 9 2 2 CD cord-010119-t1x9gknd 804 10 met meet VBD cord-010119-t1x9gknd 804 11 criteria criterion NNS cord-010119-t1x9gknd 804 12 for for IN cord-010119-t1x9gknd 804 13 positive positive JJ cord-010119-t1x9gknd 804 14 ( ( -LRB- cord-010119-t1x9gknd 804 15 1 1 CD cord-010119-t1x9gknd 804 16 was be VBD cord-010119-t1x9gknd 804 17 AltNAT AltNAT VBN cord-010119-t1x9gknd 804 18 positive positive JJ cord-010119-t1x9gknd 804 19 , , , cord-010119-t1x9gknd 804 20 IgM IgM NNP cord-010119-t1x9gknd 804 21 negative negative NNP cord-010119-t1x9gknd 804 22 and and CC cord-010119-t1x9gknd 804 23 1 1 CD cord-010119-t1x9gknd 804 24 AltNAT altnat DT cord-010119-t1x9gknd 804 25 negative negative JJ cord-010119-t1x9gknd 804 26 , , , cord-010119-t1x9gknd 804 27 IgM IgM NNP cord-010119-t1x9gknd 804 28 positive positive NNP cord-010119-t1x9gknd 804 29 ) ) -RRB- cord-010119-t1x9gknd 804 30 . . . cord-010119-t1x9gknd 805 1 1 1 CD cord-010119-t1x9gknd 805 2 donation donation NN cord-010119-t1x9gknd 805 3 is be VBZ cord-010119-t1x9gknd 805 4 pending pende VBG cord-010119-t1x9gknd 805 5 additional additional JJ cord-010119-t1x9gknd 805 6 testing testing NN cord-010119-t1x9gknd 805 7 . . . cord-010119-t1x9gknd 806 1 Altogether altogether RB cord-010119-t1x9gknd 806 2 , , , cord-010119-t1x9gknd 806 3 22/56 22/56 CD cord-010119-t1x9gknd 806 4 IR IR NNP cord-010119-t1x9gknd 806 5 donations donation NNS cord-010119-t1x9gknd 806 6 met meet VBD cord-010119-t1x9gknd 806 7 the the DT cord-010119-t1x9gknd 806 8 criteria criterion NNS cord-010119-t1x9gknd 806 9 for for IN cord-010119-t1x9gknd 806 10 true true JJ cord-010119-t1x9gknd 806 11 positive positive JJ cord-010119-t1x9gknd 806 12 on on IN cord-010119-t1x9gknd 806 13 the the DT cord-010119-t1x9gknd 806 14 index index NN cord-010119-t1x9gknd 806 15 donation donation NN cord-010119-t1x9gknd 806 16 . . . cord-010119-t1x9gknd 807 1 9/22 9/22 CD cord-010119-t1x9gknd 807 2 ( ( -LRB- cord-010119-t1x9gknd 807 3 41 41 CD cord-010119-t1x9gknd 807 4 % % NN cord-010119-t1x9gknd 807 5 ) ) -RRB- cord-010119-t1x9gknd 808 1 true true JJ cord-010119-t1x9gknd 808 2 positive positive JJ cord-010119-t1x9gknd 808 3 donations donation NNS cord-010119-t1x9gknd 808 4 were be VBD cord-010119-t1x9gknd 808 5 reactive reactive JJ cord-010119-t1x9gknd 808 6 when when WRB cord-010119-t1x9gknd 808 7 retested reteste VBN cord-010119-t1x9gknd 808 8 in in IN cord-010119-t1x9gknd 808 9 a a DT cord-010119-t1x9gknd 808 10 simulated simulated JJ cord-010119-t1x9gknd 808 11 minipool minipool NN cord-010119-t1x9gknd 808 12 . . . cord-010119-t1x9gknd 809 1 16/22 16/22 CD cord-010119-t1x9gknd 809 2 were be VBD cord-010119-t1x9gknd 809 3 IgM IgM NNP cord-010119-t1x9gknd 809 4 positive positive JJ cord-010119-t1x9gknd 809 5 . . . cord-010119-t1x9gknd 810 1 Conclusion conclusion NN cord-010119-t1x9gknd 810 2 : : : cord-010119-t1x9gknd 810 3 0.001 0.001 CD cord-010119-t1x9gknd 810 4 % % NN cord-010119-t1x9gknd 810 5 of of IN cord-010119-t1x9gknd 810 6 the the DT cord-010119-t1x9gknd 810 7 1,776,190 1,776,190 CD cord-010119-t1x9gknd 810 8 donations donation NNS cord-010119-t1x9gknd 810 9 in in IN cord-010119-t1x9gknd 810 10 US US NNP cord-010119-t1x9gknd 810 11 states state NNS cord-010119-t1x9gknd 810 12 screened screen VBN cord-010119-t1x9gknd 810 13 for for IN cord-010119-t1x9gknd 810 14 ZIKV ZIKV NNP cord-010119-t1x9gknd 810 15 RNA RNA NNP cord-010119-t1x9gknd 810 16 were be VBD cord-010119-t1x9gknd 810 17 confirmed confirm VBN cord-010119-t1x9gknd 810 18 as as IN cord-010119-t1x9gknd 810 19 true true JJ cord-010119-t1x9gknd 810 20 positives positive NNS cord-010119-t1x9gknd 810 21 . . . cord-010119-t1x9gknd 811 1 cobas cobas NNP cord-010119-t1x9gknd 811 2 V V NNP cord-010119-t1x9gknd 811 3 R R NNP cord-010119-t1x9gknd 811 4 Zika Zika NNP cord-010119-t1x9gknd 811 5 is be VBZ cord-010119-t1x9gknd 811 6 not not RB cord-010119-t1x9gknd 811 7 commercially commercially RB cord-010119-t1x9gknd 811 8 available available JJ cord-010119-t1x9gknd 811 9 for for IN cord-010119-t1x9gknd 811 10 blood blood NN cord-010119-t1x9gknd 811 11 screening screening NN cord-010119-t1x9gknd 811 12 use use NN cord-010119-t1x9gknd 811 13 . . . cord-010119-t1x9gknd 812 1 Using use VBG cord-010119-t1x9gknd 812 2 Monte Monte NNP cord-010119-t1x9gknd 812 3 Carlo Carlo NNP cord-010119-t1x9gknd 812 4 Simulation Simulation NNP cord-010119-t1x9gknd 812 5 Luiz Luiz NNP cord-010119-t1x9gknd 812 6 Amorim Amorim NNP cord-010119-t1x9gknd 812 7 * * NFP cord-010119-t1x9gknd 812 8 1 1 CD cord-010119-t1x9gknd 812 9 , , , cord-010119-t1x9gknd 812 10 Marc Marc NNP cord-010119-t1x9gknd 812 11 Germain Germain NNP cord-010119-t1x9gknd 812 12 2 2 CD cord-010119-t1x9gknd 812 13 , , , cord-010119-t1x9gknd 812 14 Gilles Gilles NNP cord-010119-t1x9gknd 812 15 Delage Delage NNP cord-010119-t1x9gknd 812 16 3 3 CD cord-010119-t1x9gknd 812 17 , , , cord-010119-t1x9gknd 812 18 Maria Maria NNP cord-010119-t1x9gknd 812 19 Esther Esther NNP cord-010119-t1x9gknd 812 20 Lopes Lopes NNP cord-010119-t1x9gknd 812 21 1 1 CD cord-010119-t1x9gknd 812 22 and and CC cord-010119-t1x9gknd 812 23 Yves Yves NNP cord-010119-t1x9gknd 812 24 Gr Gr NNP cord-010119-t1x9gknd 812 25 egoire egoire VBD cord-010119-t1x9gknd 812 26 3 3 CD cord-010119-t1x9gknd 812 27 . . NN cord-010119-t1x9gknd 812 28 1 1 CD cord-010119-t1x9gknd 812 29 HEMORIO HEMORIO NNP cord-010119-t1x9gknd 812 30 , , , cord-010119-t1x9gknd 812 31 2 2 CD cord-010119-t1x9gknd 812 32 HemaQuebec HemaQuebec NNP cord-010119-t1x9gknd 812 33 , , , cord-010119-t1x9gknd 812 34 3 3 CD cord-010119-t1x9gknd 812 35 H h NN cord-010119-t1x9gknd 812 36 ema ema NNP cord-010119-t1x9gknd 812 37 - - HYPH cord-010119-t1x9gknd 812 38 Qu Qu NNP cord-010119-t1x9gknd 812 39 ebec ebec NNP cord-010119-t1x9gknd 812 40 Background Background NNP cord-010119-t1x9gknd 812 41 / / SYM cord-010119-t1x9gknd 812 42 Case Case NNP cord-010119-t1x9gknd 812 43 Studies Studies NNPS cord-010119-t1x9gknd 812 44 : : : cord-010119-t1x9gknd 813 1 Zika Zika NNP cord-010119-t1x9gknd 813 2 virus virus NN cord-010119-t1x9gknd 813 3 was be VBD cord-010119-t1x9gknd 813 4 implicated implicate VBN cord-010119-t1x9gknd 813 5 in in IN cord-010119-t1x9gknd 813 6 very very RB cord-010119-t1x9gknd 813 7 large large JJ cord-010119-t1x9gknd 813 8 and and CC cord-010119-t1x9gknd 813 9 recent recent JJ cord-010119-t1x9gknd 813 10 outbreaks outbreak NNS cord-010119-t1x9gknd 813 11 , , , cord-010119-t1x9gknd 813 12 in in IN cord-010119-t1x9gknd 813 13 French French NNP cord-010119-t1x9gknd 813 14 Polynesia Polynesia NNP cord-010119-t1x9gknd 813 15 ( ( -LRB- cord-010119-t1x9gknd 813 16 2013 2013 CD cord-010119-t1x9gknd 813 17 ) ) -RRB- cord-010119-t1x9gknd 813 18 , , , cord-010119-t1x9gknd 813 19 and and CC cord-010119-t1x9gknd 813 20 in in IN cord-010119-t1x9gknd 813 21 Brazil Brazil NNP cord-010119-t1x9gknd 813 22 ( ( -LRB- cord-010119-t1x9gknd 813 23 2015/2016 2015/2016 CD cord-010119-t1x9gknd 813 24 ) ) -RRB- cord-010119-t1x9gknd 813 25 , , , cord-010119-t1x9gknd 813 26 which which WDT cord-010119-t1x9gknd 813 27 was be VBD cord-010119-t1x9gknd 813 28 followed follow VBN cord-010119-t1x9gknd 813 29 by by IN cord-010119-t1x9gknd 813 30 outbreaks outbreak NNS cord-010119-t1x9gknd 813 31 in in IN cord-010119-t1x9gknd 813 32 South South NNP cord-010119-t1x9gknd 813 33 America America NNP cord-010119-t1x9gknd 813 34 , , , cord-010119-t1x9gknd 813 35 Central Central NNP cord-010119-t1x9gknd 813 36 America America NNP cord-010119-t1x9gknd 813 37 and and CC cord-010119-t1x9gknd 813 38 Caribbean Caribbean NNP cord-010119-t1x9gknd 813 39 . . . cord-010119-t1x9gknd 814 1 Four four CD cord-010119-t1x9gknd 814 2 probable probable JJ cord-010119-t1x9gknd 814 3 transfusion transfusion NN cord-010119-t1x9gknd 814 4 transmitted transmit VBN cord-010119-t1x9gknd 814 5 cases case NNS cord-010119-t1x9gknd 814 6 were be VBD cord-010119-t1x9gknd 814 7 reported report VBN cord-010119-t1x9gknd 814 8 in in IN cord-010119-t1x9gknd 814 9 Brazil Brazil NNP cord-010119-t1x9gknd 814 10 ; ; : cord-010119-t1x9gknd 814 11 since since IN cord-010119-t1x9gknd 814 12 80 80 CD cord-010119-t1x9gknd 814 13 % % NN cord-010119-t1x9gknd 814 14 of of IN cord-010119-t1x9gknd 814 15 Zika Zika NNP cord-010119-t1x9gknd 814 16 cases case NNS cord-010119-t1x9gknd 814 17 are be VBP cord-010119-t1x9gknd 814 18 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 814 19 , , , cord-010119-t1x9gknd 814 20 the the DT cord-010119-t1x9gknd 814 21 actual actual JJ cord-010119-t1x9gknd 814 22 transfusion transfusion NN cord-010119-t1x9gknd 814 23 rates rate NNS cord-010119-t1x9gknd 814 24 can can MD cord-010119-t1x9gknd 814 25 be be VB cord-010119-t1x9gknd 814 26 much much RB cord-010119-t1x9gknd 814 27 higher high JJR cord-010119-t1x9gknd 814 28 than than IN cord-010119-t1x9gknd 814 29 reported report VBN cord-010119-t1x9gknd 814 30 . . . cord-010119-t1x9gknd 815 1 In in IN cord-010119-t1x9gknd 815 2 this this DT cord-010119-t1x9gknd 815 3 study study NN cord-010119-t1x9gknd 815 4 , , , cord-010119-t1x9gknd 815 5 we -PRON- PRP cord-010119-t1x9gknd 815 6 used use VBD cord-010119-t1x9gknd 815 7 a a DT cord-010119-t1x9gknd 815 8 Monte Monte NNP cord-010119-t1x9gknd 815 9 Carlo Carlo NNP cord-010119-t1x9gknd 815 10 simulation simulation NN cord-010119-t1x9gknd 815 11 for for IN cord-010119-t1x9gknd 815 12 risk risk NN cord-010119-t1x9gknd 815 13 estimation estimation NN cord-010119-t1x9gknd 815 14 during during IN cord-010119-t1x9gknd 815 15 the the DT cord-010119-t1x9gknd 815 16 Brazilian brazilian JJ cord-010119-t1x9gknd 815 17 outbreak outbreak NN cord-010119-t1x9gknd 815 18 . . . cord-010119-t1x9gknd 816 1 Study Study NNP cord-010119-t1x9gknd 816 2 Design Design NNP cord-010119-t1x9gknd 816 3 / / SYM cord-010119-t1x9gknd 816 4 Method method NN cord-010119-t1x9gknd 816 5 : : : cord-010119-t1x9gknd 817 1 The the DT cord-010119-t1x9gknd 817 2 data datum NNS cord-010119-t1x9gknd 817 3 feeding feed VBG cord-010119-t1x9gknd 817 4 the the DT cord-010119-t1x9gknd 817 5 Monte Monte NNP cord-010119-t1x9gknd 817 6 Carlo Carlo NNP cord-010119-t1x9gknd 817 7 simulation simulation NN cord-010119-t1x9gknd 817 8 were be VBD cord-010119-t1x9gknd 817 9 collected collect VBN cord-010119-t1x9gknd 817 10 from from IN cord-010119-t1x9gknd 817 11 January January NNP cord-010119-t1x9gknd 817 12 1 1 CD cord-010119-t1x9gknd 817 13 st st NNP cord-010119-t1x9gknd 817 14 , , , cord-010119-t1x9gknd 817 15 2016 2016 CD cord-010119-t1x9gknd 817 16 through through IN cord-010119-t1x9gknd 817 17 November November NNP cord-010119-t1x9gknd 817 18 , , , cord-010119-t1x9gknd 817 19 26 26 CD cord-010119-t1x9gknd 817 20 th th XX cord-010119-t1x9gknd 817 21 , , , cord-010119-t1x9gknd 817 22 2016 2016 CD cord-010119-t1x9gknd 817 23 , , , cord-010119-t1x9gknd 817 24 from from IN cord-010119-t1x9gknd 817 25 Brazil Brazil NNP cord-010119-t1x9gknd 817 26 ( ( -LRB- cord-010119-t1x9gknd 817 27 the the DT cord-010119-t1x9gknd 817 28 whole whole JJ cord-010119-t1x9gknd 817 29 country country NN cord-010119-t1x9gknd 817 30 ) ) -RRB- cord-010119-t1x9gknd 817 31 and and CC cord-010119-t1x9gknd 817 32 for for IN cord-010119-t1x9gknd 817 33 Rio Rio NNP cord-010119-t1x9gknd 817 34 de de NNP cord-010119-t1x9gknd 817 35 Janeiro Janeiro NNP cord-010119-t1x9gknd 817 36 state state NN cord-010119-t1x9gknd 817 37 , , , cord-010119-t1x9gknd 817 38 one one CD cord-010119-t1x9gknd 817 39 of of IN cord-010119-t1x9gknd 817 40 the the DT cord-010119-t1x9gknd 817 41 outbreak outbreak NN cord-010119-t1x9gknd 817 42 epicenters epicenter NNS cord-010119-t1x9gknd 817 43 . . . cord-010119-t1x9gknd 818 1 The the DT cord-010119-t1x9gknd 818 2 data datum NNS cord-010119-t1x9gknd 818 3 came come VBD cord-010119-t1x9gknd 818 4 from from IN cord-010119-t1x9gknd 818 5 Brazilian brazilian JJ cord-010119-t1x9gknd 818 6 epidemiologic epidemiologic JJ cord-010119-t1x9gknd 818 7 bulletins bulletin NNS cord-010119-t1x9gknd 818 8 and and CC cord-010119-t1x9gknd 818 9 from from IN cord-010119-t1x9gknd 818 10 Brazilian brazilian JJ cord-010119-t1x9gknd 818 11 blood blood NN cord-010119-t1x9gknd 818 12 donation donation NN cord-010119-t1x9gknd 818 13 figures figure NNS cord-010119-t1x9gknd 818 14 . . . cord-010119-t1x9gknd 819 1 The the DT cord-010119-t1x9gknd 819 2 risk risk NN cord-010119-t1x9gknd 819 3 assessment assessment NN cord-010119-t1x9gknd 819 4 was be VBD cord-010119-t1x9gknd 819 5 performed perform VBN cord-010119-t1x9gknd 819 6 separately separately RB cord-010119-t1x9gknd 819 7 for for IN cord-010119-t1x9gknd 819 8 whole whole JJ cord-010119-t1x9gknd 819 9 blood blood NN cord-010119-t1x9gknd 819 10 ( ( -LRB- cord-010119-t1x9gknd 819 11 WB WB NNP cord-010119-t1x9gknd 819 12 ) ) -RRB- cord-010119-t1x9gknd 819 13 donation donation NN cord-010119-t1x9gknd 819 14 and and CC cord-010119-t1x9gknd 819 15 for for IN cord-010119-t1x9gknd 819 16 apheresis apheresis NN cord-010119-t1x9gknd 819 17 platelets platelet NNS cord-010119-t1x9gknd 819 18 ( ( -LRB- cord-010119-t1x9gknd 819 19 AP AP NNP cord-010119-t1x9gknd 819 20 ) ) -RRB- cord-010119-t1x9gknd 819 21 . . . cord-010119-t1x9gknd 820 1 The the DT cord-010119-t1x9gknd 820 2 model model NN cord-010119-t1x9gknd 820 3 took take VBD cord-010119-t1x9gknd 820 4 into into IN cord-010119-t1x9gknd 820 5 account account NN cord-010119-t1x9gknd 820 6 the the DT cord-010119-t1x9gknd 820 7 following follow VBG cord-010119-t1x9gknd 820 8 parameters parameter NNS cord-010119-t1x9gknd 820 9 : : : cord-010119-t1x9gknd 820 10 Zika zika NN cord-010119-t1x9gknd 820 11 incidence incidence NN cord-010119-t1x9gknd 820 12 in in IN cord-010119-t1x9gknd 820 13 Brazil Brazil NNP cord-010119-t1x9gknd 820 14 and and CC cord-010119-t1x9gknd 820 15 in in IN cord-010119-t1x9gknd 820 16 Rio Rio NNP cord-010119-t1x9gknd 820 17 ; ; , cord-010119-t1x9gknd 820 18 lognormal lognormal JJ cord-010119-t1x9gknd 820 19 distribution distribution NN cord-010119-t1x9gknd 820 20 symptomatic symptomatic JJ cord-010119-t1x9gknd 820 21 viremia viremia NN cord-010119-t1x9gknd 820 22 ( ( -LRB- cord-010119-t1x9gknd 820 23 period period NN cord-010119-t1x9gknd 820 24 : : : cord-010119-t1x9gknd 820 25 5 5 CD cord-010119-t1x9gknd 820 26 days day NNS cord-010119-t1x9gknd 820 27 , , , cord-010119-t1x9gknd 820 28 with with IN cord-010119-t1x9gknd 820 29 99 99 CD cord-010119-t1x9gknd 820 30 % % NN cord-010119-t1x9gknd 820 31 of of IN cord-010119-t1x9gknd 820 32 the the DT cord-010119-t1x9gknd 820 33 values value NNS cord-010119-t1x9gknd 820 34 lower low JJR cord-010119-t1x9gknd 820 35 than than IN cord-010119-t1x9gknd 820 36 18 18 CD cord-010119-t1x9gknd 820 37 days day NNS cord-010119-t1x9gknd 820 38 ) ) -RRB- cord-010119-t1x9gknd 820 39 ; ; : cord-010119-t1x9gknd 820 40 20 20 CD cord-010119-t1x9gknd 820 41 % % NN cord-010119-t1x9gknd 820 42 of of IN cord-010119-t1x9gknd 820 43 infected infected JJ cord-010119-t1x9gknd 820 44 donors donor NNS cord-010119-t1x9gknd 820 45 with with IN cord-010119-t1x9gknd 820 46 symptoms symptom NNS cord-010119-t1x9gknd 820 47 lasting last VBG cord-010119-t1x9gknd 820 48 2 2 CD cord-010119-t1x9gknd 820 49 days day NNS cord-010119-t1x9gknd 820 50 ; ; : cord-010119-t1x9gknd 820 51 1.2 1.2 CD cord-010119-t1x9gknd 820 52 donation donation NN cord-010119-t1x9gknd 820 53 / / SYM cord-010119-t1x9gknd 820 54 donor donor NN cord-010119-t1x9gknd 820 55 / / SYM cord-010119-t1x9gknd 820 56 year year NN cord-010119-t1x9gknd 820 57 for for IN cord-010119-t1x9gknd 820 58 WB WB NNP cord-010119-t1x9gknd 820 59 and and CC cord-010119-t1x9gknd 820 60 1.75 1.75 CD cord-010119-t1x9gknd 820 61 for for IN cord-010119-t1x9gknd 820 62 AP AP NNP cord-010119-t1x9gknd 820 63 . . . cord-010119-t1x9gknd 821 1 The the DT cord-010119-t1x9gknd 821 2 formula formula NN cord-010119-t1x9gknd 821 3 for for IN cord-010119-t1x9gknd 821 4 transfusion transfusion NN cord-010119-t1x9gknd 821 5 risk risk NN cord-010119-t1x9gknd 821 6 calculation calculation NN cord-010119-t1x9gknd 821 7 was be VBD cord-010119-t1x9gknd 821 8 : : : cord-010119-t1x9gknd 822 1 incidence incidence NN cord-010119-t1x9gknd 822 2 X x POS cord-010119-t1x9gknd 822 3 infectious infectious JJ cord-010119-t1x9gknd 822 4 period period NN cord-010119-t1x9gknd 823 1 X x NN cord-010119-t1x9gknd 823 2 average average JJ cord-010119-t1x9gknd 823 3 donation donation NN cord-010119-t1x9gknd 823 4 number number NN cord-010119-t1x9gknd 823 5 per per IN cord-010119-t1x9gknd 823 6 donor donor NN cord-010119-t1x9gknd 823 7 per per IN cord-010119-t1x9gknd 823 8 year year NN cord-010119-t1x9gknd 824 1 ( ( -LRB- cord-010119-t1x9gknd 824 2 WB WB NNP cord-010119-t1x9gknd 824 3 , , , cord-010119-t1x9gknd 824 4 x x NNP cord-010119-t1x9gknd 824 5 / / SYM cord-010119-t1x9gknd 824 6 y y NNP cord-010119-t1x9gknd 824 7 ; ; : cord-010119-t1x9gknd 824 8 aph aph NNP cord-010119-t1x9gknd 824 9 , , , cord-010119-t1x9gknd 824 10 z z NNP cord-010119-t1x9gknd 824 11 / / SYM cord-010119-t1x9gknd 824 12 y y NNP cord-010119-t1x9gknd 824 13 ) ) -RRB- cord-010119-t1x9gknd 824 14 X X NNP cord-010119-t1x9gknd 824 15 ( ( -LRB- cord-010119-t1x9gknd 824 16 1 1 CD cord-010119-t1x9gknd 824 17 -proportion -proportion NN cord-010119-t1x9gknd 824 18 of of IN cord-010119-t1x9gknd 824 19 refused refuse VBN cord-010119-t1x9gknd 824 20 donors donor NNS cord-010119-t1x9gknd 824 21 ) ) -RRB- cord-010119-t1x9gknd 825 1 X X NNS cord-010119-t1x9gknd 825 2 ( ( -LRB- cord-010119-t1x9gknd 825 3 1proportion 1proportion CD cord-010119-t1x9gknd 825 4 of of IN cord-010119-t1x9gknd 825 5 discarded discard VBN cord-010119-t1x9gknd 825 6 donations donation NNS cord-010119-t1x9gknd 825 7 due due JJ cord-010119-t1x9gknd 825 8 to to TO cord-010119-t1x9gknd 825 9 post post VB cord-010119-t1x9gknd 825 10 donation donation NN cord-010119-t1x9gknd 825 11 -PD -pd IN cord-010119-t1x9gknd 825 12 -information -information NN cord-010119-t1x9gknd 825 13 ) ) -RRB- cord-010119-t1x9gknd 825 14 . . . cord-010119-t1x9gknd 826 1 Results/ Results/ . cord-010119-t1x9gknd 827 1 Finding finding NN cord-010119-t1x9gknd 827 2 : : : cord-010119-t1x9gknd 828 1 The the DT cord-010119-t1x9gknd 828 2 table table NN cord-010119-t1x9gknd 828 3 below below RB cord-010119-t1x9gknd 828 4 shows show VBZ cord-010119-t1x9gknd 828 5 the the DT cord-010119-t1x9gknd 828 6 results result NNS cord-010119-t1x9gknd 828 7 . . . cord-010119-t1x9gknd 829 1 The the DT cord-010119-t1x9gknd 829 2 estimated estimate VBN cord-010119-t1x9gknd 829 3 risk risk NN cord-010119-t1x9gknd 829 4 of of IN cord-010119-t1x9gknd 829 5 transfusion transfusion NN cord-010119-t1x9gknd 829 6 transmitted transmit VBN cord-010119-t1x9gknd 829 7 Zika Zika NNP cord-010119-t1x9gknd 829 8 is be VBZ cord-010119-t1x9gknd 829 9 very very RB cord-010119-t1x9gknd 829 10 important important JJ cord-010119-t1x9gknd 829 11 in in IN cord-010119-t1x9gknd 829 12 Brazil Brazil NNP cord-010119-t1x9gknd 829 13 and and CC cord-010119-t1x9gknd 829 14 in in IN cord-010119-t1x9gknd 829 15 Rio Rio NNP cord-010119-t1x9gknd 829 16 de de NNP cord-010119-t1x9gknd 829 17 Janeiro Janeiro NNP cord-010119-t1x9gknd 829 18 , , , cord-010119-t1x9gknd 829 19 where where WRB cord-010119-t1x9gknd 829 20 it -PRON- PRP cord-010119-t1x9gknd 829 21 can can MD cord-010119-t1x9gknd 829 22 attain attain VB cord-010119-t1x9gknd 829 23 1:13,598 1:13,598 CD cord-010119-t1x9gknd 829 24 , , , cord-010119-t1x9gknd 829 25 for for IN cord-010119-t1x9gknd 829 26 apheresis apheresis NN cord-010119-t1x9gknd 829 27 platelets platelet NNS cord-010119-t1x9gknd 829 28 . . . cord-010119-t1x9gknd 830 1 The the DT cord-010119-t1x9gknd 830 2 severe severe JJ cord-010119-t1x9gknd 830 3 consequences consequence NNS cord-010119-t1x9gknd 830 4 of of IN cord-010119-t1x9gknd 830 5 Zika Zika NNP cord-010119-t1x9gknd 830 6 in in IN cord-010119-t1x9gknd 830 7 vulnerable vulnerable JJ cord-010119-t1x9gknd 830 8 populations population NNS cord-010119-t1x9gknd 830 9 -pregnant -pregnant . cord-010119-t1x9gknd 831 1 women woman NNS cord-010119-t1x9gknd 831 2 and and CC cord-010119-t1x9gknd 831 3 newborn newborn JJ cord-010119-t1x9gknd 831 4 -indicate -indicate . cord-010119-t1x9gknd 832 1 that that IN cord-010119-t1x9gknd 832 2 interventions intervention NNS cord-010119-t1x9gknd 832 3 to to TO cord-010119-t1x9gknd 832 4 reduce reduce VB cord-010119-t1x9gknd 832 5 this this DT cord-010119-t1x9gknd 832 6 unfavorable unfavorable JJ cord-010119-t1x9gknd 832 7 outcome outcome NN cord-010119-t1x9gknd 832 8 , , , cord-010119-t1x9gknd 832 9 such such JJ cord-010119-t1x9gknd 832 10 as as IN cord-010119-t1x9gknd 832 11 donor donor NN cord-010119-t1x9gknd 832 12 testing testing NN cord-010119-t1x9gknd 832 13 and and CC cord-010119-t1x9gknd 832 14 pathogen pathogen NN cord-010119-t1x9gknd 832 15 inactivation inactivation NN cord-010119-t1x9gknd 832 16 , , , cord-010119-t1x9gknd 832 17 should should MD cord-010119-t1x9gknd 832 18 be be VB cord-010119-t1x9gknd 832 19 considered consider VBN cord-010119-t1x9gknd 832 20 in in IN cord-010119-t1x9gknd 832 21 Brazil Brazil NNP cord-010119-t1x9gknd 832 22 Dengue Dengue NNP cord-010119-t1x9gknd 832 23 ( ( -LRB- cord-010119-t1x9gknd 832 24 DENV DENV NNP cord-010119-t1x9gknd 832 25 ) ) -RRB- cord-010119-t1x9gknd 833 1 arboviruses arbovirus NNS cord-010119-t1x9gknd 833 2 in in IN cord-010119-t1x9gknd 833 3 the the DT cord-010119-t1x9gknd 833 4 population population NN cord-010119-t1x9gknd 833 5 are be VBP cord-010119-t1x9gknd 833 6 not not RB cord-010119-t1x9gknd 833 7 available available JJ cord-010119-t1x9gknd 833 8 in in IN cord-010119-t1x9gknd 833 9 Brazil Brazil NNP cord-010119-t1x9gknd 833 10 . . . cord-010119-t1x9gknd 834 1 The the DT cord-010119-t1x9gknd 834 2 objective objective NN cord-010119-t1x9gknd 834 3 of of IN cord-010119-t1x9gknd 834 4 this this DT cord-010119-t1x9gknd 834 5 study study NN cord-010119-t1x9gknd 834 6 was be VBD cord-010119-t1x9gknd 834 7 to to TO cord-010119-t1x9gknd 834 8 assess assess VB cord-010119-t1x9gknd 834 9 the the DT cord-010119-t1x9gknd 834 10 contemporaneous contemporaneous JJ cord-010119-t1x9gknd 834 11 incidence incidence NN cord-010119-t1x9gknd 834 12 of of IN cord-010119-t1x9gknd 834 13 these these DT cord-010119-t1x9gknd 834 14 agents agent NNS cord-010119-t1x9gknd 834 15 in in IN cord-010119-t1x9gknd 834 16 donors donor NNS cord-010119-t1x9gknd 834 17 at at IN cord-010119-t1x9gknd 834 18 4 4 CD cord-010119-t1x9gknd 834 19 large large JJ cord-010119-t1x9gknd 834 20 geographically geographically RB cord-010119-t1x9gknd 834 21 dispersed disperse VBN cord-010119-t1x9gknd 834 22 blood blood NN cord-010119-t1x9gknd 834 23 centers center NNS cord-010119-t1x9gknd 834 24 located locate VBN cord-010119-t1x9gknd 834 25 in in IN cord-010119-t1x9gknd 834 26 the the DT cord-010119-t1x9gknd 834 27 southeast southeast NN cord-010119-t1x9gknd 834 28 and and CC cord-010119-t1x9gknd 834 29 northeast northeast RB cord-010119-t1x9gknd 834 30 of of IN cord-010119-t1x9gknd 834 31 Brazil Brazil NNP cord-010119-t1x9gknd 834 32 . . . cord-010119-t1x9gknd 835 1 Study Study NNP cord-010119-t1x9gknd 835 2 Design Design NNP cord-010119-t1x9gknd 835 3 / / SYM cord-010119-t1x9gknd 835 4 Method method NN cord-010119-t1x9gknd 835 5 : : : cord-010119-t1x9gknd 836 1 In in IN cord-010119-t1x9gknd 836 2 the the DT cord-010119-t1x9gknd 836 3 Brazil Brazil NNP cord-010119-t1x9gknd 836 4 public public JJ cord-010119-t1x9gknd 836 5 blood blood NN cord-010119-t1x9gknd 836 6 bank bank NN cord-010119-t1x9gknd 836 7 system system NN cord-010119-t1x9gknd 836 8 , , , cord-010119-t1x9gknd 836 9 NAT NAT NNP cord-010119-t1x9gknd 836 10 screening screening NN cord-010119-t1x9gknd 836 11 for for IN cord-010119-t1x9gknd 836 12 HIV HIV NNP cord-010119-t1x9gknd 836 13 , , , cord-010119-t1x9gknd 836 14 HCV HCV NNP cord-010119-t1x9gknd 836 15 and and CC cord-010119-t1x9gknd 836 16 HBV HBV NNP cord-010119-t1x9gknd 836 17 is be VBZ cord-010119-t1x9gknd 836 18 performed perform VBN cord-010119-t1x9gknd 836 19 on on IN cord-010119-t1x9gknd 836 20 minipools minipool NNS cord-010119-t1x9gknd 836 21 ( ( -LRB- cord-010119-t1x9gknd 836 22 MP MP NNP cord-010119-t1x9gknd 836 23 from from IN cord-010119-t1x9gknd 836 24 6 6 CD cord-010119-t1x9gknd 836 25 donations donation NNS cord-010119-t1x9gknd 836 26 ) ) -RRB- cord-010119-t1x9gknd 836 27 . . . cord-010119-t1x9gknd 837 1 The the DT cord-010119-t1x9gknd 837 2 residual residual JJ cord-010119-t1x9gknd 837 3 volume volume NN cord-010119-t1x9gknd 837 4 of of IN cord-010119-t1x9gknd 837 5 MP MP NNP cord-010119-t1x9gknd 837 6 plasma plasma NN cord-010119-t1x9gknd 837 7 , , , cord-010119-t1x9gknd 837 8 0.35 0.35 CD cord-010119-t1x9gknd 837 9 -0.45 -0.45 NNS cord-010119-t1x9gknd 837 10 mL ml NN cord-010119-t1x9gknd 837 11 , , , cord-010119-t1x9gknd 837 12 is be VBZ cord-010119-t1x9gknd 837 13 routinely routinely RB cord-010119-t1x9gknd 837 14 discarded discard VBN cord-010119-t1x9gknd 837 15 . . . cord-010119-t1x9gknd 838 1 Beginning begin VBG cord-010119-t1x9gknd 838 2 in in IN cord-010119-t1x9gknd 838 3 April April NNP cord-010119-t1x9gknd 838 4 2016 2016 CD cord-010119-t1x9gknd 838 5 each each DT cord-010119-t1x9gknd 838 6 blood blood NN cord-010119-t1x9gknd 838 7 center center NN cord-010119-t1x9gknd 838 8 saved save VBD cord-010119-t1x9gknd 838 9 $ $ $ cord-010119-t1x9gknd 838 10 67 67 CD cord-010119-t1x9gknd 838 11 MPs mp NNS cord-010119-t1x9gknd 838 12 / / SYM cord-010119-t1x9gknd 838 13 week week NN cord-010119-t1x9gknd 838 14 for for IN cord-010119-t1x9gknd 838 15 retrospective retrospective JJ cord-010119-t1x9gknd 838 16 testing testing NN cord-010119-t1x9gknd 838 17 using use VBG cord-010119-t1x9gknd 838 18 the the DT cord-010119-t1x9gknd 838 19 triplex triplex NN cord-010119-t1x9gknd 838 20 ZIKV ZIKV NNP cord-010119-t1x9gknd 838 21 , , , cord-010119-t1x9gknd 838 22 CHIKV CHIKV NNP cord-010119-t1x9gknd 838 23 , , , cord-010119-t1x9gknd 838 24 DENV DENV NNP cord-010119-t1x9gknd 838 25 Transcription Transcription NNP cord-010119-t1x9gknd 838 26 Mediated mediate VBN cord-010119-t1x9gknd 838 27 Amplification Amplification NNP cord-010119-t1x9gknd 838 28 ( ( -LRB- cord-010119-t1x9gknd 838 29 TMA TMA NNP cord-010119-t1x9gknd 838 30 ) ) -RRB- cord-010119-t1x9gknd 838 31 assay assay NN cord-010119-t1x9gknd 838 32 developed develop VBN cord-010119-t1x9gknd 838 33 by by IN cord-010119-t1x9gknd 838 34 Grifols Grifols NNP cord-010119-t1x9gknd 838 35 / / SYM cord-010119-t1x9gknd 838 36 Hologic Hologic NNP cord-010119-t1x9gknd 838 37 . . . cord-010119-t1x9gknd 839 1 MPs mp NNS cord-010119-t1x9gknd 839 2 were be VBD cord-010119-t1x9gknd 839 3 shipped ship VBN cord-010119-t1x9gknd 839 4 to to IN cord-010119-t1x9gknd 839 5 the the DT cord-010119-t1x9gknd 839 6 USA USA NNP cord-010119-t1x9gknd 839 7 and and CC cord-010119-t1x9gknd 839 8 batch batch NN cord-010119-t1x9gknd 839 9 tested test VBN cord-010119-t1x9gknd 839 10 at at IN cord-010119-t1x9gknd 839 11 Grifols Grifols NNP cord-010119-t1x9gknd 839 12 . . . cord-010119-t1x9gknd 840 1 In in IN cord-010119-t1x9gknd 840 2 the the DT cord-010119-t1x9gknd 840 3 first first JJ cord-010119-t1x9gknd 840 4 two two CD cord-010119-t1x9gknd 840 5 weeks week NNS cord-010119-t1x9gknd 840 6 ( ( -LRB- cord-010119-t1x9gknd 840 7 April April NNP cord-010119-t1x9gknd 840 8 3 3 CD cord-010119-t1x9gknd 840 9 - - SYM cord-010119-t1x9gknd 840 10 15 15 CD cord-010119-t1x9gknd 840 11 ) ) -RRB- cord-010119-t1x9gknd 840 12 3 3 CD cord-010119-t1x9gknd 840 13 MP6 MP6 NNP cord-010119-t1x9gknd 840 14 were be VBD cord-010119-t1x9gknd 840 15 combined combine VBN cord-010119-t1x9gknd 840 16 into into IN cord-010119-t1x9gknd 840 17 pools pool NNS cord-010119-t1x9gknd 840 18 of of IN cord-010119-t1x9gknd 840 19 18 18 CD cord-010119-t1x9gknd 840 20 donations donation NNS cord-010119-t1x9gknd 840 21 ; ; : cord-010119-t1x9gknd 840 22 thereafter thereafter RB cord-010119-t1x9gknd 840 23 MP6 MP6 NNP cord-010119-t1x9gknd 840 24 were be VBD cord-010119-t1x9gknd 840 25 tested test VBN cord-010119-t1x9gknd 840 26 without without IN cord-010119-t1x9gknd 840 27 additional additional JJ cord-010119-t1x9gknd 840 28 pooling pooling NN cord-010119-t1x9gknd 840 29 . . . cord-010119-t1x9gknd 841 1 To to TO cord-010119-t1x9gknd 841 2 estimate estimate VB cord-010119-t1x9gknd 841 3 the the DT cord-010119-t1x9gknd 841 4 percent percent NN cord-010119-t1x9gknd 841 5 positive positive JJ cord-010119-t1x9gknd 841 6 donors donor NNS cord-010119-t1x9gknd 841 7 , , , cord-010119-t1x9gknd 841 8 the the DT cord-010119-t1x9gknd 841 9 denominator denominator NN cord-010119-t1x9gknd 841 10 was be VBD cord-010119-t1x9gknd 841 11 adjusted adjust VBN cord-010119-t1x9gknd 841 12 to to TO cord-010119-t1x9gknd 841 13 account account VB cord-010119-t1x9gknd 841 14 for for IN cord-010119-t1x9gknd 841 15 the the DT cord-010119-t1x9gknd 841 16 number number NN cord-010119-t1x9gknd 841 17 of of IN cord-010119-t1x9gknd 841 18 donations donation NNS cord-010119-t1x9gknd 841 19 included include VBN cord-010119-t1x9gknd 841 20 in in IN cord-010119-t1x9gknd 841 21 each each DT cord-010119-t1x9gknd 841 22 pool pool NN cord-010119-t1x9gknd 841 23 each each DT cord-010119-t1x9gknd 841 24 month month NN cord-010119-t1x9gknd 841 25 and and CC cord-010119-t1x9gknd 841 26 95 95 CD cord-010119-t1x9gknd 841 27 % % NN cord-010119-t1x9gknd 841 28 confidence confidence NN cord-010119-t1x9gknd 841 29 intervals interval NNS cord-010119-t1x9gknd 841 30 ( ( -LRB- cord-010119-t1x9gknd 841 31 CI CI NNP cord-010119-t1x9gknd 841 32 ) ) -RRB- cord-010119-t1x9gknd 841 33 calculated calculate VBD cord-010119-t1x9gknd 841 34 using use VBG cord-010119-t1x9gknd 841 35 the the DT cord-010119-t1x9gknd 841 36 method method NN cord-010119-t1x9gknd 841 37 developed develop VBN cord-010119-t1x9gknd 841 38 by by IN cord-010119-t1x9gknd 841 39 Biggerstaff Biggerstaff NNP cord-010119-t1x9gknd 841 40 . . . cord-010119-t1x9gknd 842 1 Results/ Results/ . cord-010119-t1x9gknd 843 1 Finding finding NN cord-010119-t1x9gknd 843 2 : : : cord-010119-t1x9gknd 844 1 The the DT cord-010119-t1x9gknd 844 2 triplex triplex NN cord-010119-t1x9gknd 844 3 assay assay NN cord-010119-t1x9gknd 844 4 performance performance NN cord-010119-t1x9gknd 844 5 was be VBD cord-010119-t1x9gknd 844 6 shown show VBN cord-010119-t1x9gknd 844 7 to to TO cord-010119-t1x9gknd 844 8 have have VB cord-010119-t1x9gknd 844 9 very very RB cord-010119-t1x9gknd 844 10 high high JJ cord-010119-t1x9gknd 844 11 sensitivity sensitivity NN cord-010119-t1x9gknd 844 12 ( ( -LRB- cord-010119-t1x9gknd 844 13 95 95 CD cord-010119-t1x9gknd 844 14 % % NN cord-010119-t1x9gknd 844 15 limit limit NN cord-010119-t1x9gknd 844 16 of of IN cord-010119-t1x9gknd 844 17 detection detection NN cord-010119-t1x9gknd 844 18 < < XX cord-010119-t1x9gknd 844 19 20 20 CD cord-010119-t1x9gknd 844 20 copies copy NNS cord-010119-t1x9gknd 844 21 / / SYM cord-010119-t1x9gknd 844 22 mL ml NN cord-010119-t1x9gknd 844 23 for for IN cord-010119-t1x9gknd 844 24 ZIKV ZIKV NNP cord-010119-t1x9gknd 844 25 / / SYM cord-010119-t1x9gknd 844 26 CHIKV/ CHIKV/ NNP cord-010119-t1x9gknd 844 27 DENVs denv NNS cord-010119-t1x9gknd 844 28 ) ) -RRB- cord-010119-t1x9gknd 844 29 and and CC cord-010119-t1x9gknd 844 30 to to TO cord-010119-t1x9gknd 844 31 accurately accurately RB cord-010119-t1x9gknd 844 32 discriminate discriminate VB cord-010119-t1x9gknd 844 33 each each DT cord-010119-t1x9gknd 844 34 of of IN cord-010119-t1x9gknd 844 35 the the DT cord-010119-t1x9gknd 844 36 arboviruses arbovirus NNS cord-010119-t1x9gknd 844 37 . . . cord-010119-t1x9gknd 845 1 Testing testing NN cord-010119-t1x9gknd 845 2 of of IN cord-010119-t1x9gknd 845 3 the the DT cord-010119-t1x9gknd 845 4 first first JJ cord-010119-t1x9gknd 845 5 6 6 CD cord-010119-t1x9gknd 845 6 months month NNS cord-010119-t1x9gknd 845 7 of of IN cord-010119-t1x9gknd 845 8 samples sample NNS cord-010119-t1x9gknd 845 9 is be VBZ cord-010119-t1x9gknd 845 10 complete complete JJ cord-010119-t1x9gknd 845 11 for for IN cord-010119-t1x9gknd 845 12 6,292 6,292 CD cord-010119-t1x9gknd 845 13 MP MP NNP cord-010119-t1x9gknd 845 14 , , , cord-010119-t1x9gknd 845 15 comprised comprise VBN cord-010119-t1x9gknd 845 16 of of IN cord-010119-t1x9gknd 845 17 37,752 37,752 CD cord-010119-t1x9gknd 845 18 donations donation NNS cord-010119-t1x9gknd 845 19 collected collect VBN cord-010119-t1x9gknd 845 20 from from IN cord-010119-t1x9gknd 845 21 April April NNP cord-010119-t1x9gknd 845 22 3 3 CD cord-010119-t1x9gknd 845 23 to to IN cord-010119-t1x9gknd 845 24 October October NNP cord-010119-t1x9gknd 845 25 9 9 CD cord-010119-t1x9gknd 845 26 , , , cord-010119-t1x9gknd 845 27 2016 2016 CD cord-010119-t1x9gknd 845 28 . . . cord-010119-t1x9gknd 846 1 A a DT cord-010119-t1x9gknd 846 2 total total NN cord-010119-t1x9gknd 846 3 of of IN cord-010119-t1x9gknd 846 4 77 77 CD cord-010119-t1x9gknd 846 5 pools pool NNS cord-010119-t1x9gknd 846 6 were be VBD cord-010119-t1x9gknd 846 7 positive positive JJ cord-010119-t1x9gknd 846 8 , , , cord-010119-t1x9gknd 846 9 with with IN cord-010119-t1x9gknd 846 10 76 76 CD cord-010119-t1x9gknd 846 11 detected detect VBN cord-010119-t1x9gknd 846 12 between between IN cord-010119-t1x9gknd 846 13 April April NNP cord-010119-t1x9gknd 846 14 - - HYPH cord-010119-t1x9gknd 846 15 June June NNP cord-010119-t1x9gknd 846 16 2016 2016 CD cord-010119-t1x9gknd 846 17 . . . cord-010119-t1x9gknd 847 1 The the DT cord-010119-t1x9gknd 847 2 table table NN cord-010119-t1x9gknd 847 3 summarizes summarize VBZ cord-010119-t1x9gknd 847 4 the the DT cord-010119-t1x9gknd 847 5 highest high JJS cord-010119-t1x9gknd 847 6 monthly monthly JJ cord-010119-t1x9gknd 847 7 estimated estimate VBN cord-010119-t1x9gknd 847 8 percent percent NN cord-010119-t1x9gknd 847 9 positive positive JJ cord-010119-t1x9gknd 847 10 donors donor NNS cord-010119-t1x9gknd 847 11 for for IN cord-010119-t1x9gknd 847 12 each each DT cord-010119-t1x9gknd 847 13 virus virus NN cord-010119-t1x9gknd 847 14 in in IN cord-010119-t1x9gknd 847 15 each each DT cord-010119-t1x9gknd 847 16 city city NN cord-010119-t1x9gknd 847 17 . . . cord-010119-t1x9gknd 848 1 Months month NNS cord-010119-t1x9gknd 848 2 with with IN cord-010119-t1x9gknd 848 3 highest high JJS cord-010119-t1x9gknd 848 4 percent percent NN cord-010119-t1x9gknd 849 1 postive postive JJ cord-010119-t1x9gknd 849 2 donors donor NNS cord-010119-t1x9gknd 849 3 were be VBD cord-010119-t1x9gknd 849 4 April April NNP cord-010119-t1x9gknd 849 5 or or CC cord-010119-t1x9gknd 850 1 May. May NNP cord-010119-t1x9gknd 850 2 At at IN cord-010119-t1x9gknd 850 3 the the DT cord-010119-t1x9gknd 850 4 peak peak NN cord-010119-t1x9gknd 850 5 over over IN cord-010119-t1x9gknd 850 6 0.6 0.6 CD cord-010119-t1x9gknd 850 7 % % NN cord-010119-t1x9gknd 850 8 of of IN cord-010119-t1x9gknd 850 9 donors donor NNS cord-010119-t1x9gknd 850 10 in in IN cord-010119-t1x9gknd 850 11 Belo Belo NNP cord-010119-t1x9gknd 850 12 Horizonte Horizonte NNP cord-010119-t1x9gknd 850 13 and and CC cord-010119-t1x9gknd 850 14 Rio Rio NNP cord-010119-t1x9gknd 850 15 were be VBD cord-010119-t1x9gknd 850 16 viremic viremic JJ cord-010119-t1x9gknd 850 17 for for IN cord-010119-t1x9gknd 850 18 ZIKV ZIKV NNP cord-010119-t1x9gknd 850 19 , , , cord-010119-t1x9gknd 850 20 whereas whereas IN cord-010119-t1x9gknd 850 21 ZIKA ZIKA NNP cord-010119-t1x9gknd 850 22 was be VBD cord-010119-t1x9gknd 850 23 not not RB cord-010119-t1x9gknd 850 24 evident evident JJ cord-010119-t1x9gknd 850 25 in in IN cord-010119-t1x9gknd 850 26 donors donor NNS cord-010119-t1x9gknd 850 27 in in IN cord-010119-t1x9gknd 850 28 Recife Recife NNP cord-010119-t1x9gknd 850 29 , , , cord-010119-t1x9gknd 850 30 but but CC cord-010119-t1x9gknd 850 31 over over IN cord-010119-t1x9gknd 850 32 0.4 0.4 CD cord-010119-t1x9gknd 850 33 % % NN cord-010119-t1x9gknd 850 34 of of IN cord-010119-t1x9gknd 850 35 donors donor NNS cord-010119-t1x9gknd 850 36 in in IN cord-010119-t1x9gknd 850 37 that that DT cord-010119-t1x9gknd 850 38 city city NN cord-010119-t1x9gknd 850 39 were be VBD cord-010119-t1x9gknd 850 40 viremic viremic JJ cord-010119-t1x9gknd 850 41 for for IN cord-010119-t1x9gknd 850 42 CHIVK CHIVK NNP cord-010119-t1x9gknd 850 43 during during IN cord-010119-t1x9gknd 850 44 the the DT cord-010119-t1x9gknd 850 45 peak peak NN cord-010119-t1x9gknd 850 46 . . . cord-010119-t1x9gknd 851 1 Conclusion conclusion NN cord-010119-t1x9gknd 851 2 : : : cord-010119-t1x9gknd 852 1 During during IN cord-010119-t1x9gknd 852 2 the the DT cord-010119-t1x9gknd 852 3 latter latter JJ cord-010119-t1x9gknd 852 4 part part NN cord-010119-t1x9gknd 852 5 of of IN cord-010119-t1x9gknd 852 6 the the DT cord-010119-t1x9gknd 852 7 arbovirus arbovirus NN cord-010119-t1x9gknd 852 8 outbreak outbreak NN cord-010119-t1x9gknd 852 9 season season NN cord-010119-t1x9gknd 852 10 in in IN cord-010119-t1x9gknd 852 11 Brazil Brazil NNP cord-010119-t1x9gknd 852 12 in in IN cord-010119-t1x9gknd 852 13 2016 2016 CD cord-010119-t1x9gknd 852 14 , , , cord-010119-t1x9gknd 852 15 ZIKV ZIKV NNP cord-010119-t1x9gknd 852 16 , , , cord-010119-t1x9gknd 852 17 CHIKV CHIKV NNP cord-010119-t1x9gknd 852 18 , , , cord-010119-t1x9gknd 852 19 and and CC cord-010119-t1x9gknd 852 20 DENV DENV NNP cord-010119-t1x9gknd 852 21 were be VBD cord-010119-t1x9gknd 852 22 being be VBG cord-010119-t1x9gknd 852 23 transmitted transmit VBN cord-010119-t1x9gknd 852 24 by by IN cord-010119-t1x9gknd 852 25 mosquitoes mosquito NNS cord-010119-t1x9gknd 852 26 to to IN cord-010119-t1x9gknd 852 27 donors donor NNS cord-010119-t1x9gknd 852 28 with with IN cord-010119-t1x9gknd 852 29 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 852 30 donors donor NNS cord-010119-t1x9gknd 852 31 donating donate VBG cord-010119-t1x9gknd 852 32 , , , cord-010119-t1x9gknd 852 33 indicating indicate VBG cord-010119-t1x9gknd 852 34 that that IN cord-010119-t1x9gknd 852 35 blood blood NN cord-010119-t1x9gknd 852 36 recipients recipient NNS cord-010119-t1x9gknd 852 37 in in IN cord-010119-t1x9gknd 852 38 Brazil Brazil NNP cord-010119-t1x9gknd 852 39 were be VBD cord-010119-t1x9gknd 852 40 extensively extensively RB cord-010119-t1x9gknd 852 41 exposed expose VBN cord-010119-t1x9gknd 852 42 to to IN cord-010119-t1x9gknd 852 43 viremic viremic JJ cord-010119-t1x9gknd 852 44 blood blood NN cord-010119-t1x9gknd 852 45 components component NNS cord-010119-t1x9gknd 852 46 . . . cord-010119-t1x9gknd 853 1 The the DT cord-010119-t1x9gknd 853 2 use use NN cord-010119-t1x9gknd 853 3 of of IN cord-010119-t1x9gknd 853 4 donor donor NN cord-010119-t1x9gknd 853 5 MPs mp NNS cord-010119-t1x9gknd 853 6 for for IN cord-010119-t1x9gknd 853 7 surveillance surveillance NN cord-010119-t1x9gknd 853 8 may may MD cord-010119-t1x9gknd 853 9 be be VB cord-010119-t1x9gknd 853 10 one one CD cord-010119-t1x9gknd 853 11 of of IN cord-010119-t1x9gknd 853 12 the the DT cord-010119-t1x9gknd 853 13 most most RBS cord-010119-t1x9gknd 853 14 efficient efficient JJ cord-010119-t1x9gknd 853 15 approaches approach NNS cord-010119-t1x9gknd 853 16 for for IN cord-010119-t1x9gknd 853 17 public public JJ cord-010119-t1x9gknd 853 18 health health NN cord-010119-t1x9gknd 853 19 monitoring monitoring NN cord-010119-t1x9gknd 853 20 of of IN cord-010119-t1x9gknd 853 21 the the DT cord-010119-t1x9gknd 853 22 onset onset NN cord-010119-t1x9gknd 853 23 and and CC cord-010119-t1x9gknd 853 24 magnitude magnitude NN cord-010119-t1x9gknd 853 25 of of IN cord-010119-t1x9gknd 853 26 arbovirus arbovirus NN cord-010119-t1x9gknd 853 27 infections infection NNS cord-010119-t1x9gknd 853 28 . . . cord-010119-t1x9gknd 854 1 Universal Universal NNP cord-010119-t1x9gknd 854 2 Zika Zika NNP cord-010119-t1x9gknd 854 3 Screening Screening NNP cord-010119-t1x9gknd 854 4 for for IN cord-010119-t1x9gknd 854 5 Blood blood NN cord-010119-t1x9gknd 854 6 Donors donor NNS cord-010119-t1x9gknd 854 7 in in IN cord-010119-t1x9gknd 854 8 Singapore Singapore NNP cord-010119-t1x9gknd 854 9 Sally Sally NNP cord-010119-t1x9gknd 854 10 Lam Lam NNP cord-010119-t1x9gknd 855 1 * * NFP cord-010119-t1x9gknd 855 2 1 1 CD cord-010119-t1x9gknd 855 3 , , , cord-010119-t1x9gknd 855 4 Sze Sze NNP cord-010119-t1x9gknd 855 5 Sze Sze NNP cord-010119-t1x9gknd 855 6 Chua Chua NNP cord-010119-t1x9gknd 855 7 1 1 CD cord-010119-t1x9gknd 855 8 , , , cord-010119-t1x9gknd 855 9 Mars Mars NNP cord-010119-t1x9gknd 855 10 Stone Stone NNP cord-010119-t1x9gknd 855 11 2 2 CD cord-010119-t1x9gknd 855 12 , , , cord-010119-t1x9gknd 855 13 Michael Michael NNP cord-010119-t1x9gknd 855 14 Paul Paul NNP cord-010119-t1x9gknd 855 15 Busch Busch NNP cord-010119-t1x9gknd 855 16 2 2 CD cord-010119-t1x9gknd 855 17 and and CC cord-010119-t1x9gknd 855 18 Ai Ai NNP cord-010119-t1x9gknd 855 19 Leen Leen NNP cord-010119-t1x9gknd 855 20 Ang Ang NNP cord-010119-t1x9gknd 855 21 1 1 CD cord-010119-t1x9gknd 855 22 . . . cord-010119-t1x9gknd 856 1 1 1 CD cord-010119-t1x9gknd 856 2 Health Health NNP cord-010119-t1x9gknd 856 3 Sciences Sciences NNPS cord-010119-t1x9gknd 856 4 Authority Authority NNP cord-010119-t1x9gknd 856 5 , , , cord-010119-t1x9gknd 856 6 Blood Blood NNP cord-010119-t1x9gknd 856 7 Services Services NNPS cord-010119-t1x9gknd 856 8 Group Group NNP cord-010119-t1x9gknd 856 9 , , , cord-010119-t1x9gknd 856 10 2 2 CD cord-010119-t1x9gknd 856 11 Blood Blood NNP cord-010119-t1x9gknd 856 12 Systems Systems NNPS cord-010119-t1x9gknd 856 13 Research Research NNP cord-010119-t1x9gknd 856 14 Institute Institute NNP cord-010119-t1x9gknd 856 15 Background Background NNP cord-010119-t1x9gknd 856 16 / / SYM cord-010119-t1x9gknd 856 17 Case Case NNP cord-010119-t1x9gknd 856 18 Studies Studies NNPS cord-010119-t1x9gknd 857 1 : : : cord-010119-t1x9gknd 857 2 Singapore Singapore NNP cord-010119-t1x9gknd 857 3 reported report VBD cord-010119-t1x9gknd 857 4 its -PRON- PRP$ cord-010119-t1x9gknd 857 5 first first JJ cord-010119-t1x9gknd 857 6 locally locally RB cord-010119-t1x9gknd 857 7 transmitted transmit VBN cord-010119-t1x9gknd 857 8 Zika Zika NNP cord-010119-t1x9gknd 857 9 case case NN cord-010119-t1x9gknd 857 10 on on IN cord-010119-t1x9gknd 857 11 26 26 CD cord-010119-t1x9gknd 857 12 August August NNP cord-010119-t1x9gknd 857 13 2016 2016 CD cord-010119-t1x9gknd 857 14 . . . cord-010119-t1x9gknd 858 1 The the DT cord-010119-t1x9gknd 858 2 numbers number NNS cord-010119-t1x9gknd 858 3 rose rise VBD cord-010119-t1x9gknd 858 4 rapidly rapidly RB cord-010119-t1x9gknd 858 5 to to IN cord-010119-t1x9gknd 858 6 386 386 CD cord-010119-t1x9gknd 858 7 cases case NNS cord-010119-t1x9gknd 858 8 by by IN cord-010119-t1x9gknd 858 9 the the DT cord-010119-t1x9gknd 858 10 end end NN cord-010119-t1x9gknd 858 11 September September NNP cord-010119-t1x9gknd 858 12 , , , cord-010119-t1x9gknd 858 13 with with IN cord-010119-t1x9gknd 858 14 eight eight CD cord-010119-t1x9gknd 858 15 clusters cluster NNS cord-010119-t1x9gknd 858 16 ( ( -LRB- cord-010119-t1x9gknd 858 17 hotspots hotspot NNS cord-010119-t1x9gknd 858 18 ) ) -RRB- cord-010119-t1x9gknd 858 19 of of IN cord-010119-t1x9gknd 858 20 cases case NNS cord-010119-t1x9gknd 858 21 island island NN cord-010119-t1x9gknd 858 22 - - HYPH cord-010119-t1x9gknd 858 23 wide wide RB cord-010119-t1x9gknd 858 24 . . . cord-010119-t1x9gknd 859 1 Zika Zika NNP cord-010119-t1x9gknd 859 2 virus virus NN cord-010119-t1x9gknd 859 3 ( ( -LRB- cord-010119-t1x9gknd 859 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 859 5 ) ) -RRB- cord-010119-t1x9gknd 859 6 shares share VBZ cord-010119-t1x9gknd 859 7 the the DT cord-010119-t1x9gknd 859 8 same same JJ cord-010119-t1x9gknd 859 9 mosquito mosquito NN cord-010119-t1x9gknd 859 10 vector vector NN cord-010119-t1x9gknd 859 11 , , , cord-010119-t1x9gknd 859 12 Aedes Aedes NNP cord-010119-t1x9gknd 859 13 aegypti aegypti NN cord-010119-t1x9gknd 859 14 , , , cord-010119-t1x9gknd 859 15 as as IN cord-010119-t1x9gknd 859 16 the the DT cord-010119-t1x9gknd 859 17 Dengue dengue NN cord-010119-t1x9gknd 859 18 viruses virus NNS cord-010119-t1x9gknd 859 19 and and CC cord-010119-t1x9gknd 859 20 can can MD cord-010119-t1x9gknd 859 21 caused cause VBN cord-010119-t1x9gknd 859 22 microcephaly microcephaly NNS cord-010119-t1x9gknd 859 23 in in IN cord-010119-t1x9gknd 859 24 unborn unborn JJ cord-010119-t1x9gknd 859 25 fetuses fetus NNS cord-010119-t1x9gknd 859 26 of of IN cord-010119-t1x9gknd 859 27 infected infected JJ cord-010119-t1x9gknd 859 28 pregnant pregnant JJ cord-010119-t1x9gknd 859 29 women woman NNS cord-010119-t1x9gknd 859 30 and and CC cord-010119-t1x9gknd 859 31 Guillan Guillan NNP cord-010119-t1x9gknd 859 32 - - HYPH cord-010119-t1x9gknd 859 33 Barr Barr NNP cord-010119-t1x9gknd 859 34 e e NNP cord-010119-t1x9gknd 859 35 syndrome syndrome NN cord-010119-t1x9gknd 859 36 , , , cord-010119-t1x9gknd 859 37 which which WDT cord-010119-t1x9gknd 859 38 hastened hasten VBD cord-010119-t1x9gknd 859 39 Singapore Singapore NNP cord-010119-t1x9gknd 859 40 's 's POS cord-010119-t1x9gknd 859 41 Blood Blood NNP cord-010119-t1x9gknd 859 42 Services Services NNPS cord-010119-t1x9gknd 859 43 Group Group NNP cord-010119-t1x9gknd 859 44 ( ( -LRB- cord-010119-t1x9gknd 859 45 BSG BSG NNP cord-010119-t1x9gknd 859 46 ) ) -RRB- cord-010119-t1x9gknd 859 47 to to TO cord-010119-t1x9gknd 859 48 look look VB cord-010119-t1x9gknd 859 49 into into IN cord-010119-t1x9gknd 859 50 securing secure VBG cord-010119-t1x9gknd 859 51 the the DT cord-010119-t1x9gknd 859 52 safety safety NN cord-010119-t1x9gknd 859 53 of of IN cord-010119-t1x9gknd 859 54 blood blood NN cord-010119-t1x9gknd 859 55 supply supply NN cord-010119-t1x9gknd 859 56 from from IN cord-010119-t1x9gknd 859 57 the the DT cord-010119-t1x9gknd 859 58 Zika Zika NNP cord-010119-t1x9gknd 859 59 threat threat NN cord-010119-t1x9gknd 859 60 . . . cord-010119-t1x9gknd 860 1 We -PRON- PRP cord-010119-t1x9gknd 860 2 aimed aim VBD cord-010119-t1x9gknd 860 3 to to TO cord-010119-t1x9gknd 860 4 assess assess VB cord-010119-t1x9gknd 860 5 the the DT cord-010119-t1x9gknd 860 6 assay assay NN cord-010119-t1x9gknd 860 7 performance performance NN cord-010119-t1x9gknd 860 8 of of IN cord-010119-t1x9gknd 860 9 USA USA NNP cord-010119-t1x9gknd 860 10 - - HYPH cord-010119-t1x9gknd 860 11 FDA FDA NNP cord-010119-t1x9gknd 860 12 investigational investigational NN cord-010119-t1x9gknd 860 13 ( ( -LRB- cord-010119-t1x9gknd 860 14 IND IND NNP cord-010119-t1x9gknd 860 15 ) ) -RRB- cord-010119-t1x9gknd 860 16 Procleix Procleix NNP cord-010119-t1x9gknd 860 17 ZIKV ZIKV NNP cord-010119-t1x9gknd 860 18 nucleic nucleic JJ cord-010119-t1x9gknd 860 19 acid acid NN cord-010119-t1x9gknd 860 20 technology technology NN cord-010119-t1x9gknd 860 21 ( ( -LRB- cord-010119-t1x9gknd 860 22 NAT NAT NNP cord-010119-t1x9gknd 860 23 ) ) -RRB- cord-010119-t1x9gknd 860 24 assay assay NN cord-010119-t1x9gknd 860 25 for for IN cord-010119-t1x9gknd 860 26 universal universal JJ cord-010119-t1x9gknd 860 27 blood blood NN cord-010119-t1x9gknd 860 28 donation donation NN cord-010119-t1x9gknd 860 29 screening screening NN cord-010119-t1x9gknd 860 30 in in IN cord-010119-t1x9gknd 860 31 Singapore Singapore NNP cord-010119-t1x9gknd 860 32 to to TO cord-010119-t1x9gknd 860 33 prevent prevent VB cord-010119-t1x9gknd 860 34 transfusion transfusion NN cord-010119-t1x9gknd 860 35 - - HYPH cord-010119-t1x9gknd 860 36 transmitted transmit VBN cord-010119-t1x9gknd 860 37 Zika Zika NNP cord-010119-t1x9gknd 860 38 infection infection NN cord-010119-t1x9gknd 860 39 . . . cord-010119-t1x9gknd 861 1 Study Study NNP cord-010119-t1x9gknd 861 2 Design Design NNP cord-010119-t1x9gknd 861 3 / / SYM cord-010119-t1x9gknd 861 4 Method method NN cord-010119-t1x9gknd 861 5 : : : cord-010119-t1x9gknd 861 6 All all DT cord-010119-t1x9gknd 861 7 blood blood NN cord-010119-t1x9gknd 861 8 donations donation NNS cord-010119-t1x9gknd 861 9 were be VBD cord-010119-t1x9gknd 861 10 screened screen VBN cord-010119-t1x9gknd 861 11 for for IN cord-010119-t1x9gknd 861 12 Zika Zika NNP cord-010119-t1x9gknd 861 13 with with IN cord-010119-t1x9gknd 861 14 the the DT cord-010119-t1x9gknd 861 15 Procleix Procleix NNP cord-010119-t1x9gknd 861 16 ZIKV ZIKV NNP cord-010119-t1x9gknd 861 17 NAT NAT NNP cord-010119-t1x9gknd 861 18 assay assay NN cord-010119-t1x9gknd 861 19 since since IN cord-010119-t1x9gknd 861 20 1 1 CD cord-010119-t1x9gknd 861 21 October October NNP cord-010119-t1x9gknd 861 22 2016 2016 CD cord-010119-t1x9gknd 861 23 . . . cord-010119-t1x9gknd 862 1 Zika Zika NNP cord-010119-t1x9gknd 862 2 NAT NAT NNP cord-010119-t1x9gknd 862 3 reactive reactive JJ cord-010119-t1x9gknd 862 4 samples sample NNS cord-010119-t1x9gknd 862 5 were be VBD cord-010119-t1x9gknd 862 6 tested test VBN cord-010119-t1x9gknd 862 7 at at IN cord-010119-t1x9gknd 862 8 Blood Blood NNP cord-010119-t1x9gknd 862 9 System System NNP cord-010119-t1x9gknd 862 10 Research Research NNP cord-010119-t1x9gknd 862 11 Institute Institute NNP cord-010119-t1x9gknd 862 12 ( ( -LRB- cord-010119-t1x9gknd 862 13 BSRI BSRI NNP cord-010119-t1x9gknd 862 14 ) ) -RRB- cord-010119-t1x9gknd 862 15 for for IN cord-010119-t1x9gknd 862 16 Zika Zika NNP cord-010119-t1x9gknd 862 17 RNA RNA NNP cord-010119-t1x9gknd 862 18 in in IN cord-010119-t1x9gknd 862 19 plasma plasma NN cord-010119-t1x9gknd 862 20 and and CC cord-010119-t1x9gknd 862 21 red red JJ cord-010119-t1x9gknd 862 22 cells cell NNS cord-010119-t1x9gknd 862 23 by by IN cord-010119-t1x9gknd 862 24 PCR PCR NNP cord-010119-t1x9gknd 862 25 and and CC cord-010119-t1x9gknd 862 26 for for IN cord-010119-t1x9gknd 862 27 Zika Zika NNP cord-010119-t1x9gknd 862 28 and and CC cord-010119-t1x9gknd 862 29 Dengue Dengue NNP cord-010119-t1x9gknd 862 30 IgM IgM NNP cord-010119-t1x9gknd 862 31 and and CC cord-010119-t1x9gknd 862 32 IgG IgG NNP cord-010119-t1x9gknd 862 33 antibodies antibody NNS cord-010119-t1x9gknd 862 34 . . . cord-010119-t1x9gknd 863 1 A a DT cord-010119-t1x9gknd 863 2 Zika Zika NNP cord-010119-t1x9gknd 863 3 confirmed confirm VBD cord-010119-t1x9gknd 863 4 case case NN cord-010119-t1x9gknd 863 5 was be VBD cord-010119-t1x9gknd 863 6 defined define VBN cord-010119-t1x9gknd 863 7 by by IN cord-010119-t1x9gknd 863 8 the the DT cord-010119-t1x9gknd 863 9 presence presence NN cord-010119-t1x9gknd 863 10 of of IN cord-010119-t1x9gknd 863 11 Zika Zika NNP cord-010119-t1x9gknd 863 12 RNA RNA NNP cord-010119-t1x9gknd 863 13 by by IN cord-010119-t1x9gknd 863 14 PCR PCR NNP cord-010119-t1x9gknd 863 15 and/or and/or CC cord-010119-t1x9gknd 863 16 Zika Zika NNP cord-010119-t1x9gknd 863 17 antibodies antibody NNS cord-010119-t1x9gknd 863 18 . . . cord-010119-t1x9gknd 864 1 The the DT cord-010119-t1x9gknd 864 2 analytical analytical JJ cord-010119-t1x9gknd 864 3 sensitivity sensitivity NN cord-010119-t1x9gknd 864 4 was be VBD cord-010119-t1x9gknd 864 5 evaluated evaluate VBN cord-010119-t1x9gknd 864 6 using use VBG cord-010119-t1x9gknd 864 7 300 300 CD cord-010119-t1x9gknd 864 8 blinded blind VBN cord-010119-t1x9gknd 864 9 frozen frozen JJ cord-010119-t1x9gknd 864 10 samples sample NNS cord-010119-t1x9gknd 864 11 consisting consist VBG cord-010119-t1x9gknd 864 12 of of IN cord-010119-t1x9gknd 864 13 25 25 CD cord-010119-t1x9gknd 864 14 replicates replicate NNS cord-010119-t1x9gknd 864 15 of of IN cord-010119-t1x9gknd 864 16 11 11 CD cord-010119-t1x9gknd 864 17 half half NN cord-010119-t1x9gknd 864 18 log log NN cord-010119-t1x9gknd 864 19 dilutions dilution NNS cord-010119-t1x9gknd 864 20 of of IN cord-010119-t1x9gknd 864 21 the the DT cord-010119-t1x9gknd 864 22 WHO WHO NNP cord-010119-t1x9gknd 864 23 International International NNP cord-010119-t1x9gknd 864 24 Standard Standard NNP cord-010119-t1x9gknd 864 25 for for IN cord-010119-t1x9gknd 864 26 ZIKV ZIKV NNP cord-010119-t1x9gknd 864 27 and and CC cord-010119-t1x9gknd 864 28 25 25 CD cord-010119-t1x9gknd 864 29 replicates replicate NNS cord-010119-t1x9gknd 864 30 of of IN cord-010119-t1x9gknd 864 31 negative negative JJ cord-010119-t1x9gknd 864 32 controls control NNS cord-010119-t1x9gknd 864 33 prepared prepare VBN cord-010119-t1x9gknd 864 34 by by IN cord-010119-t1x9gknd 864 35 BSRI BSRI NNP cord-010119-t1x9gknd 864 36 . . . cord-010119-t1x9gknd 865 1 Probit probit NN cord-010119-t1x9gknd 865 2 analysis analysis NN cord-010119-t1x9gknd 865 3 was be VBD cord-010119-t1x9gknd 865 4 performed perform VBN cord-010119-t1x9gknd 865 5 to to TO cord-010119-t1x9gknd 865 6 determine determine VB cord-010119-t1x9gknd 865 7 the the DT cord-010119-t1x9gknd 865 8 50 50 CD cord-010119-t1x9gknd 865 9 % % NN cord-010119-t1x9gknd 865 10 and and CC cord-010119-t1x9gknd 865 11 95 95 CD cord-010119-t1x9gknd 865 12 % % NN cord-010119-t1x9gknd 865 13 limits limit NNS cord-010119-t1x9gknd 865 14 of of IN cord-010119-t1x9gknd 865 15 detection detection NN cord-010119-t1x9gknd 865 16 ( ( -LRB- cord-010119-t1x9gknd 865 17 LOD lod NN cord-010119-t1x9gknd 865 18 ) ) -RRB- cord-010119-t1x9gknd 865 19 . . . cord-010119-t1x9gknd 866 1 Clinical clinical JJ cord-010119-t1x9gknd 866 2 performance performance NN cord-010119-t1x9gknd 866 3 of of IN cord-010119-t1x9gknd 866 4 the the DT cord-010119-t1x9gknd 866 5 Procleix Procleix NNP cord-010119-t1x9gknd 866 6 ZIKV ZIKV NNP cord-010119-t1x9gknd 866 7 assay assay NN cord-010119-t1x9gknd 866 8 was be VBD cord-010119-t1x9gknd 866 9 also also RB cord-010119-t1x9gknd 866 10 assessed assess VBN cord-010119-t1x9gknd 866 11 with with IN cord-010119-t1x9gknd 866 12 local local JJ cord-010119-t1x9gknd 866 13 patient patient NN cord-010119-t1x9gknd 866 14 samples sample NNS cord-010119-t1x9gknd 866 15 obtained obtain VBN cord-010119-t1x9gknd 866 16 from from IN cord-010119-t1x9gknd 866 17 Institute Institute NNP cord-010119-t1x9gknd 866 18 of of IN cord-010119-t1x9gknd 866 19 Infectious Infectious NNP cord-010119-t1x9gknd 866 20 Disease Disease NNP cord-010119-t1x9gknd 866 21 and and CC cord-010119-t1x9gknd 866 22 Epidemiology Epidemiology NNP cord-010119-t1x9gknd 866 23 , , , cord-010119-t1x9gknd 866 24 Singapore Singapore NNP cord-010119-t1x9gknd 866 25 and and CC cord-010119-t1x9gknd 866 26 a a DT cord-010119-t1x9gknd 866 27 14 14 CD cord-010119-t1x9gknd 866 28 member member NN cord-010119-t1x9gknd 866 29 blinded blind VBN cord-010119-t1x9gknd 866 30 ZIKV ZIKV NNP cord-010119-t1x9gknd 866 31 reference reference NN cord-010119-t1x9gknd 866 32 panel panel NN cord-010119-t1x9gknd 866 33 from from IN cord-010119-t1x9gknd 866 34 the the DT cord-010119-t1x9gknd 866 35 USA USA NNP cord-010119-t1x9gknd 866 36 - - HYPH cord-010119-t1x9gknd 866 37 FDA FDA NNP cord-010119-t1x9gknd 866 38 . . . cord-010119-t1x9gknd 867 1 Results/ Results/ . cord-010119-t1x9gknd 868 1 Finding finding NN cord-010119-t1x9gknd 868 2 : : : cord-010119-t1x9gknd 868 3 A a DT cord-010119-t1x9gknd 868 4 total total NN cord-010119-t1x9gknd 868 5 of of IN cord-010119-t1x9gknd 868 6 63,144 63,144 CD cord-010119-t1x9gknd 868 7 donations donation NNS cord-010119-t1x9gknd 868 8 were be VBD cord-010119-t1x9gknd 868 9 screened screen VBN cord-010119-t1x9gknd 868 10 from from IN cord-010119-t1x9gknd 868 11 1 1 CD cord-010119-t1x9gknd 868 12 October October NNP cord-010119-t1x9gknd 868 13 2016 2016 CD cord-010119-t1x9gknd 868 14 to to IN cord-010119-t1x9gknd 868 15 31 31 CD cord-010119-t1x9gknd 868 16 March March NNP cord-010119-t1x9gknd 868 17 2017 2017 CD cord-010119-t1x9gknd 868 18 , , , cord-010119-t1x9gknd 868 19 with with IN cord-010119-t1x9gknd 868 20 1 1 CD cord-010119-t1x9gknd 868 21 false false JJ cord-010119-t1x9gknd 868 22 positive positive JJ cord-010119-t1x9gknd 868 23 case case NN cord-010119-t1x9gknd 868 24 and and CC cord-010119-t1x9gknd 868 25 1 1 CD cord-010119-t1x9gknd 868 26 Zika Zika NNP cord-010119-t1x9gknd 868 27 confirmed confirm VBD cord-010119-t1x9gknd 868 28 donation donation NN cord-010119-t1x9gknd 868 29 detected detect VBD cord-010119-t1x9gknd 868 30 . . . cord-010119-t1x9gknd 869 1 Alternative alternative JJ cord-010119-t1x9gknd 869 2 ZIKV ZIKV NNP cord-010119-t1x9gknd 869 3 PCR PCR NNP cord-010119-t1x9gknd 869 4 tested test VBD cord-010119-t1x9gknd 869 5 positive positive JJ cord-010119-t1x9gknd 869 6 in in IN cord-010119-t1x9gknd 869 7 both both CC cord-010119-t1x9gknd 869 8 the the DT cord-010119-t1x9gknd 869 9 plasma plasma NN cord-010119-t1x9gknd 869 10 and and CC cord-010119-t1x9gknd 869 11 red red JJ cord-010119-t1x9gknd 869 12 cells cell NNS cord-010119-t1x9gknd 869 13 with with IN cord-010119-t1x9gknd 869 14 an an DT cord-010119-t1x9gknd 869 15 estimated estimate VBN cord-010119-t1x9gknd 869 16 plasma plasma NN cord-010119-t1x9gknd 869 17 viral viral JJ cord-010119-t1x9gknd 869 18 load load NN cord-010119-t1x9gknd 869 19 of of IN cord-010119-t1x9gknd 869 20 9.54x10 9.54x10 CD cord-010119-t1x9gknd 869 21 5 5 CD cord-010119-t1x9gknd 869 22 copies copy NNS cord-010119-t1x9gknd 869 23 / / SYM cord-010119-t1x9gknd 869 24 ml ml NN cord-010119-t1x9gknd 869 25 . . . cord-010119-t1x9gknd 870 1 Zika Zika NNP cord-010119-t1x9gknd 870 2 IgM IgM NNP cord-010119-t1x9gknd 870 3 was be VBD cord-010119-t1x9gknd 870 4 negative negative JJ cord-010119-t1x9gknd 870 5 in in IN cord-010119-t1x9gknd 870 6 the the DT cord-010119-t1x9gknd 870 7 index index NN cord-010119-t1x9gknd 870 8 donation donation NN cord-010119-t1x9gknd 870 9 sample sample NN cord-010119-t1x9gknd 870 10 but but CC cord-010119-t1x9gknd 870 11 present present JJ cord-010119-t1x9gknd 870 12 in in IN cord-010119-t1x9gknd 870 13 the the DT cord-010119-t1x9gknd 870 14 10-day 10-day CD cord-010119-t1x9gknd 870 15 post post JJ cord-010119-t1x9gknd 870 16 - - NN cord-010119-t1x9gknd 870 17 donation donation NN cord-010119-t1x9gknd 870 18 follow follow VB cord-010119-t1x9gknd 870 19 up up RP cord-010119-t1x9gknd 870 20 sample sample NN cord-010119-t1x9gknd 870 21 .. .. . cord-010119-t1x9gknd 871 1 The the DT cord-010119-t1x9gknd 871 2 donor donor NN cord-010119-t1x9gknd 871 3 reported report VBD cord-010119-t1x9gknd 871 4 no no DT cord-010119-t1x9gknd 871 5 clinical clinical JJ cord-010119-t1x9gknd 871 6 symptoms symptom NNS cord-010119-t1x9gknd 871 7 . . . cord-010119-t1x9gknd 872 1 The the DT cord-010119-t1x9gknd 872 2 analytical analytical JJ cord-010119-t1x9gknd 872 3 sensitivity sensitivity NN cord-010119-t1x9gknd 872 4 for for IN cord-010119-t1x9gknd 872 5 the the DT cord-010119-t1x9gknd 872 6 Procleix Procleix NNP cord-010119-t1x9gknd 872 7 ZIKV ZIKV NNP cord-010119-t1x9gknd 872 8 assay assay NN cord-010119-t1x9gknd 872 9 was be VBD cord-010119-t1x9gknd 872 10 determined determine VBN cord-010119-t1x9gknd 872 11 to to TO cord-010119-t1x9gknd 872 12 be be VB cord-010119-t1x9gknd 872 13 2.1 2.1 CD cord-010119-t1x9gknd 872 14 copies copy NNS cord-010119-t1x9gknd 872 15 / / SYM cord-010119-t1x9gknd 872 16 ml ml NN cord-010119-t1x9gknd 872 17 at at IN cord-010119-t1x9gknd 872 18 50 50 CD cord-010119-t1x9gknd 872 19 % % NN cord-010119-t1x9gknd 872 20 LOD lod NN cord-010119-t1x9gknd 872 21 and and CC cord-010119-t1x9gknd 873 1 10.0 10.0 CD cord-010119-t1x9gknd 873 2 copies copy NNS cord-010119-t1x9gknd 873 3 / / SYM cord-010119-t1x9gknd 873 4 ml ml XX cord-010119-t1x9gknd 873 5 at at IN cord-010119-t1x9gknd 873 6 95 95 CD cord-010119-t1x9gknd 873 7 % % NN cord-010119-t1x9gknd 873 8 LOD lod NN cord-010119-t1x9gknd 873 9 . . . cord-010119-t1x9gknd 874 1 The the DT cord-010119-t1x9gknd 874 2 Procleix Procleix NNP cord-010119-t1x9gknd 874 3 ZIKV ZIKV NNP cord-010119-t1x9gknd 874 4 assay assay NN cord-010119-t1x9gknd 874 5 detected detect VBD cord-010119-t1x9gknd 874 6 RNA RNA NNP cord-010119-t1x9gknd 874 7 in in IN cord-010119-t1x9gknd 874 8 6 6 CD cord-010119-t1x9gknd 874 9 out out IN cord-010119-t1x9gknd 874 10 of of IN cord-010119-t1x9gknd 874 11 9 9 CD cord-010119-t1x9gknd 874 12 patient patient NN cord-010119-t1x9gknd 874 13 samples sample NNS cord-010119-t1x9gknd 874 14 and and CC cord-010119-t1x9gknd 874 15 provided provide VBD cord-010119-t1x9gknd 874 16 85.7 85.7 CD cord-010119-t1x9gknd 874 17 % % NN cord-010119-t1x9gknd 874 18 agreement agreement NN cord-010119-t1x9gknd 874 19 to to IN cord-010119-t1x9gknd 874 20 the the DT cord-010119-t1x9gknd 874 21 results result NNS cord-010119-t1x9gknd 874 22 of of IN cord-010119-t1x9gknd 874 23 the the DT cord-010119-t1x9gknd 874 24 USA USA NNP cord-010119-t1x9gknd 874 25 - - HYPH cord-010119-t1x9gknd 874 26 FDA FDA NNP cord-010119-t1x9gknd 874 27 ZIKV ZIKV NNP cord-010119-t1x9gknd 874 28 reference reference NN cord-010119-t1x9gknd 874 29 material material NN cord-010119-t1x9gknd 874 30 . . . cord-010119-t1x9gknd 875 1 Conclusion conclusion NN cord-010119-t1x9gknd 875 2 : : : cord-010119-t1x9gknd 876 1 The the DT cord-010119-t1x9gknd 876 2 investigational investigational JJ cord-010119-t1x9gknd 876 3 Procleix Procleix NNP cord-010119-t1x9gknd 876 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 876 5 assay assay NN cord-010119-t1x9gknd 876 6 showed show VBD cord-010119-t1x9gknd 876 7 good good JJ cord-010119-t1x9gknd 876 8 analytical analytical JJ cord-010119-t1x9gknd 876 9 sensitivity sensitivity NN cord-010119-t1x9gknd 876 10 and and CC cord-010119-t1x9gknd 876 11 clinical clinical JJ cord-010119-t1x9gknd 876 12 performance performance NN cord-010119-t1x9gknd 876 13 , , , cord-010119-t1x9gknd 876 14 suitable suitable JJ cord-010119-t1x9gknd 876 15 for for IN cord-010119-t1x9gknd 876 16 blood blood NN cord-010119-t1x9gknd 876 17 screening screening NN cord-010119-t1x9gknd 876 18 of of IN cord-010119-t1x9gknd 876 19 Zika Zika NNP cord-010119-t1x9gknd 876 20 infection infection NN cord-010119-t1x9gknd 876 21 especially especially RB cord-010119-t1x9gknd 876 22 in in IN cord-010119-t1x9gknd 876 23 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 876 24 donor donor NN cord-010119-t1x9gknd 876 25 populations population NNS cord-010119-t1x9gknd 876 26 . . . cord-010119-t1x9gknd 877 1 BSG BSG NNP cord-010119-t1x9gknd 877 2 commenced commence VBD cord-010119-t1x9gknd 877 3 universal universal JJ cord-010119-t1x9gknd 877 4 Zika Zika NNP cord-010119-t1x9gknd 877 5 NAT NAT NNP cord-010119-t1x9gknd 877 6 screening screening NN cord-010119-t1x9gknd 877 7 by by IN cord-010119-t1x9gknd 877 8 individual individual JJ cord-010119-t1x9gknd 877 9 donation donation NN cord-010119-t1x9gknd 877 10 testing testing NN cord-010119-t1x9gknd 877 11 following follow VBG cord-010119-t1x9gknd 877 12 the the DT cord-010119-t1x9gknd 877 13 Zika Zika NNP cord-010119-t1x9gknd 877 14 outbreak outbreak NN cord-010119-t1x9gknd 877 15 with with IN cord-010119-t1x9gknd 877 16 1 1 CD cord-010119-t1x9gknd 877 17 confirmed confirm VBN cord-010119-t1x9gknd 877 18 Zika Zika NNP cord-010119-t1x9gknd 877 19 donation donation NN cord-010119-t1x9gknd 877 20 ( ( -LRB- cord-010119-t1x9gknd 877 21 high high JJ cord-010119-t1x9gknd 877 22 - - HYPH cord-010119-t1x9gknd 877 23 titer titer NN cord-010119-t1x9gknd 877 24 and and CC cord-010119-t1x9gknd 877 25 seronegative seronegative JJ cord-010119-t1x9gknd 877 26 ) ) -RRB- cord-010119-t1x9gknd 877 27 interdicted interdict VBN cord-010119-t1x9gknd 877 28 , , , cord-010119-t1x9gknd 877 29 which which WDT cord-010119-t1x9gknd 877 30 translates translate VBZ cord-010119-t1x9gknd 877 31 to to IN cord-010119-t1x9gknd 877 32 a a DT cord-010119-t1x9gknd 877 33 risk risk NN cord-010119-t1x9gknd 877 34 incidence incidence NN cord-010119-t1x9gknd 877 35 of of IN cord-010119-t1x9gknd 877 36 1 1 CD cord-010119-t1x9gknd 877 37 in in IN cord-010119-t1x9gknd 877 38 25,888 25,888 CD cord-010119-t1x9gknd 877 39 donations donation NNS cord-010119-t1x9gknd 877 40 in in IN cord-010119-t1x9gknd 877 41 Singapore Singapore NNP cord-010119-t1x9gknd 877 42 . . . cord-010119-t1x9gknd 878 1 Background Background NNP cord-010119-t1x9gknd 878 2 / / SYM cord-010119-t1x9gknd 878 3 Case Case NNP cord-010119-t1x9gknd 878 4 Studies Studies NNPS cord-010119-t1x9gknd 878 5 : : : cord-010119-t1x9gknd 879 1 A a DT cord-010119-t1x9gknd 879 2 CAP cap NN cord-010119-t1x9gknd 879 3 / / SYM cord-010119-t1x9gknd 879 4 AABB AABB NNP cord-010119-t1x9gknd 879 5 Work Work NNP cord-010119-t1x9gknd 879 6 Group Group NNP cord-010119-t1x9gknd 879 7 suggested suggest VBD cord-010119-t1x9gknd 879 8 that that IN cord-010119-t1x9gknd 879 9 steps step NNS cord-010119-t1x9gknd 879 10 be be VB cord-010119-t1x9gknd 879 11 taken take VBN cord-010119-t1x9gknd 879 12 to to TO cord-010119-t1x9gknd 879 13 phase phase VB cord-010119-t1x9gknd 879 14 in in IN cord-010119-t1x9gknd 879 15 RHDgenotyping rhdgenotype VBG cord-010119-t1x9gknd 879 16 for for IN cord-010119-t1x9gknd 879 17 patients patient NNS cord-010119-t1x9gknd 879 18 with with IN cord-010119-t1x9gknd 879 19 a a DT cord-010119-t1x9gknd 879 20 serologic serologic JJ cord-010119-t1x9gknd 879 21 weak weak JJ cord-010119-t1x9gknd 879 22 D d NN cord-010119-t1x9gknd 879 23 phenotype phenotype NN cord-010119-t1x9gknd 879 24 . . . cord-010119-t1x9gknd 880 1 Weak weak JJ cord-010119-t1x9gknd 880 2 D d NN cord-010119-t1x9gknd 880 3 types type NNS cord-010119-t1x9gknd 880 4 1 1 CD cord-010119-t1x9gknd 880 5 , , , cord-010119-t1x9gknd 880 6 2 2 CD cord-010119-t1x9gknd 880 7 and and CC cord-010119-t1x9gknd 880 8 3 3 CD cord-010119-t1x9gknd 880 9 express express VBP cord-010119-t1x9gknd 880 10 all all PDT cord-010119-t1x9gknd 880 11 the the DT cord-010119-t1x9gknd 880 12 major major JJ cord-010119-t1x9gknd 880 13 RhD rhd NN cord-010119-t1x9gknd 880 14 epitopes epitope NNS cord-010119-t1x9gknd 880 15 and and CC cord-010119-t1x9gknd 880 16 these these DT cord-010119-t1x9gknd 880 17 patients patient NNS cord-010119-t1x9gknd 880 18 can can MD cord-010119-t1x9gknd 880 19 be be VB cord-010119-t1x9gknd 880 20 managed manage VBN cord-010119-t1x9gknd 880 21 as as IN cord-010119-t1x9gknd 880 22 RhD rhd NN cord-010119-t1x9gknd 880 23 - - HYPH cord-010119-t1x9gknd 880 24 positive positive JJ cord-010119-t1x9gknd 880 25 , , , cord-010119-t1x9gknd 880 26 which which WDT cord-010119-t1x9gknd 880 27 may may MD cord-010119-t1x9gknd 880 28 lead lead VB cord-010119-t1x9gknd 880 29 to to IN cord-010119-t1x9gknd 880 30 a a DT cord-010119-t1x9gknd 880 31 reduction reduction NN cord-010119-t1x9gknd 880 32 in in IN cord-010119-t1x9gknd 880 33 unnecessary unnecessary JJ cord-010119-t1x9gknd 880 34 Rh Rh NNP cord-010119-t1x9gknd 880 35 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 880 36 ( ( -LRB- cord-010119-t1x9gknd 880 37 RhIG RhIG NNP cord-010119-t1x9gknd 880 38 ) ) -RRB- cord-010119-t1x9gknd 880 39 administration administration NN cord-010119-t1x9gknd 880 40 and and CC cord-010119-t1x9gknd 880 41 conservation conservation NN cord-010119-t1x9gknd 880 42 of of IN cord-010119-t1x9gknd 880 43 RhD rhd NN cord-010119-t1x9gknd 880 44 - - HYPH cord-010119-t1x9gknd 880 45 negative negative JJ cord-010119-t1x9gknd 880 46 RBCs rbc NNS cord-010119-t1x9gknd 880 47 . . . cord-010119-t1x9gknd 881 1 Study Study NNP cord-010119-t1x9gknd 881 2 Design Design NNP cord-010119-t1x9gknd 881 3 / / SYM cord-010119-t1x9gknd 881 4 Method method NN cord-010119-t1x9gknd 881 5 : : : cord-010119-t1x9gknd 882 1 RHD RHD NNP cord-010119-t1x9gknd 882 2 genotyping genotyping NN cord-010119-t1x9gknd 882 3 was be VBD cord-010119-t1x9gknd 882 4 performed perform VBN cord-010119-t1x9gknd 882 5 on on IN cord-010119-t1x9gknd 882 6 all all DT cord-010119-t1x9gknd 882 7 patient patient JJ cord-010119-t1x9gknd 882 8 samples sample NNS cord-010119-t1x9gknd 882 9 with with IN cord-010119-t1x9gknd 882 10 weaker weak JJR cord-010119-t1x9gknd 882 11 than than IN cord-010119-t1x9gknd 882 12 expected expect VBN cord-010119-t1x9gknd 882 13 or or CC cord-010119-t1x9gknd 882 14 discrepant discrepant JJ cord-010119-t1x9gknd 882 15 RhD rhd NN cord-010119-t1x9gknd 882 16 typing typing NN cord-010119-t1x9gknd 882 17 results result NNS cord-010119-t1x9gknd 882 18 , , , cord-010119-t1x9gknd 882 19 utilizing utilize VBG cord-010119-t1x9gknd 882 20 a a DT cord-010119-t1x9gknd 882 21 commercially commercially RB cord-010119-t1x9gknd 882 22 available available JJ cord-010119-t1x9gknd 882 23 genotyping genotyping NN cord-010119-t1x9gknd 882 24 kit kit NN cord-010119-t1x9gknd 882 25 manufactured manufacture VBN cord-010119-t1x9gknd 882 26 by by IN cord-010119-t1x9gknd 882 27 Immucor Immucor NNP cord-010119-t1x9gknd 882 28 ( ( -LRB- cord-010119-t1x9gknd 882 29 RHD RHD NNP cord-010119-t1x9gknd 882 30 BeadChip BeadChip NNP cord-010119-t1x9gknd 882 31 ) ) -RRB- cord-010119-t1x9gknd 882 32 . . . cord-010119-t1x9gknd 883 1 Initially initially RB cord-010119-t1x9gknd 883 2 , , , cord-010119-t1x9gknd 883 3 testing testing NN cord-010119-t1x9gknd 883 4 was be VBD cord-010119-t1x9gknd 883 5 performed perform VBN cord-010119-t1x9gknd 883 6 at at IN cord-010119-t1x9gknd 883 7 a a DT cord-010119-t1x9gknd 883 8 reference reference NN cord-010119-t1x9gknd 883 9 lab lab NN cord-010119-t1x9gknd 883 10 while while IN cord-010119-t1x9gknd 883 11 the the DT cord-010119-t1x9gknd 883 12 RHD RHD NNP cord-010119-t1x9gknd 883 13 BeadChip BeadChip NNP cord-010119-t1x9gknd 883 14 was be VBD cord-010119-t1x9gknd 883 15 validated validate VBN cord-010119-t1x9gknd 883 16 and and CC cord-010119-t1x9gknd 883 17 implemented implement VBN cord-010119-t1x9gknd 883 18 at at IN cord-010119-t1x9gknd 883 19 this this DT cord-010119-t1x9gknd 883 20 institution institution NN cord-010119-t1x9gknd 883 21 . . . cord-010119-t1x9gknd 884 1 A a DT cord-010119-t1x9gknd 884 2 serologic serologic JJ cord-010119-t1x9gknd 884 3 weak weak JJ cord-010119-t1x9gknd 884 4 D d NN cord-010119-t1x9gknd 884 5 phenotype phenotype NN cord-010119-t1x9gknd 884 6 is be VBZ cord-010119-t1x9gknd 884 7 defined define VBN cord-010119-t1x9gknd 884 8 as as IN cord-010119-t1x9gknd 884 9 weak weak JJ cord-010119-t1x9gknd 884 10 to to IN cord-010119-t1x9gknd 884 11 21 21 CD cord-010119-t1x9gknd 884 12 reactivity reactivity NN cord-010119-t1x9gknd 884 13 on on IN cord-010119-t1x9gknd 884 14 initial initial JJ cord-010119-t1x9gknd 884 15 gel gel NN cord-010119-t1x9gknd 884 16 testing testing NN cord-010119-t1x9gknd 884 17 . . . cord-010119-t1x9gknd 885 1 If if IN cord-010119-t1x9gknd 885 2 genotyping genotype VBG cord-010119-t1x9gknd 885 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 885 4 weak weak JJ cord-010119-t1x9gknd 885 5 D d NN cord-010119-t1x9gknd 885 6 types type NNS cord-010119-t1x9gknd 885 7 1 1 CD cord-010119-t1x9gknd 885 8 , , , cord-010119-t1x9gknd 885 9 2 2 CD cord-010119-t1x9gknd 885 10 or or CC cord-010119-t1x9gknd 885 11 3 3 CD cord-010119-t1x9gknd 885 12 , , , cord-010119-t1x9gknd 885 13 the the DT cord-010119-t1x9gknd 885 14 intent intent NN cord-010119-t1x9gknd 885 15 was be VBD cord-010119-t1x9gknd 885 16 to to TO cord-010119-t1x9gknd 885 17 manage manage VB cord-010119-t1x9gknd 885 18 the the DT cord-010119-t1x9gknd 885 19 patient patient NN cord-010119-t1x9gknd 885 20 as as IN cord-010119-t1x9gknd 885 21 RhD rhd NN cord-010119-t1x9gknd 885 22 - - HYPH cord-010119-t1x9gknd 885 23 positive positive JJ cord-010119-t1x9gknd 885 24 . . . cord-010119-t1x9gknd 886 1 If if IN cord-010119-t1x9gknd 886 2 weak weak JJ cord-010119-t1x9gknd 886 3 D d NN cord-010119-t1x9gknd 886 4 types type NNS cord-010119-t1x9gknd 886 5 1 1 CD cord-010119-t1x9gknd 886 6 , , , cord-010119-t1x9gknd 886 7 2 2 CD cord-010119-t1x9gknd 886 8 or or CC cord-010119-t1x9gknd 886 9 3 3 CD cord-010119-t1x9gknd 886 10 were be VBD cord-010119-t1x9gknd 886 11 NOT not RB cord-010119-t1x9gknd 886 12 detected detect VBN cord-010119-t1x9gknd 886 13 , , , cord-010119-t1x9gknd 886 14 the the DT cord-010119-t1x9gknd 886 15 patient patient NN cord-010119-t1x9gknd 886 16 is be VBZ cord-010119-t1x9gknd 886 17 considered consider VBN cord-010119-t1x9gknd 886 18 at at IN cord-010119-t1x9gknd 886 19 risk risk NN cord-010119-t1x9gknd 886 20 for for IN cord-010119-t1x9gknd 886 21 alloimmunization alloimmunization NN cord-010119-t1x9gknd 886 22 and and CC cord-010119-t1x9gknd 886 23 treated treat VBN cord-010119-t1x9gknd 886 24 as as IN cord-010119-t1x9gknd 886 25 RhDnegative RhDnegative NNP cord-010119-t1x9gknd 886 26 . . . cord-010119-t1x9gknd 887 1 While while IN cord-010119-t1x9gknd 887 2 RHD RHD NNP cord-010119-t1x9gknd 887 3 genotyping genotyping NN cord-010119-t1x9gknd 887 4 results result NNS cord-010119-t1x9gknd 887 5 were be VBD cord-010119-t1x9gknd 887 6 pending pende VBG cord-010119-t1x9gknd 887 7 , , , cord-010119-t1x9gknd 887 8 RhD rhd NN cord-010119-t1x9gknd 887 9 - - HYPH cord-010119-t1x9gknd 887 10 negative negative JJ cord-010119-t1x9gknd 887 11 RBCs rbc NNS cord-010119-t1x9gknd 887 12 were be VBD cord-010119-t1x9gknd 887 13 used use VBN cord-010119-t1x9gknd 887 14 and and CC cord-010119-t1x9gknd 887 15 if if IN cord-010119-t1x9gknd 887 16 pregnant pregnant JJ cord-010119-t1x9gknd 887 17 , , , cord-010119-t1x9gknd 887 18 the the DT cord-010119-t1x9gknd 887 19 patient patient NN cord-010119-t1x9gknd 887 20 was be VBD cord-010119-t1x9gknd 887 21 eligible eligible JJ cord-010119-t1x9gknd 887 22 for for IN cord-010119-t1x9gknd 887 23 RhIG rhig NN cord-010119-t1x9gknd 887 24 . . . cord-010119-t1x9gknd 888 1 Results result NNS cord-010119-t1x9gknd 888 2 were be VBD cord-010119-t1x9gknd 888 3 generally generally RB cord-010119-t1x9gknd 888 4 available available JJ cord-010119-t1x9gknd 888 5 in in IN cord-010119-t1x9gknd 888 6 2 2 CD cord-010119-t1x9gknd 888 7 to to TO cord-010119-t1x9gknd 888 8 4 4 CD cord-010119-t1x9gknd 888 9 weeks week NNS cord-010119-t1x9gknd 888 10 . . . cord-010119-t1x9gknd 889 1 Results/ Results/ . cord-010119-t1x9gknd 890 1 Finding finding NN cord-010119-t1x9gknd 890 2 : : : cord-010119-t1x9gknd 890 3 RHDgenotyping rhdgenotype VBG cord-010119-t1x9gknd 890 4 was be VBD cord-010119-t1x9gknd 890 5 performed perform VBN cord-010119-t1x9gknd 890 6 on on IN cord-010119-t1x9gknd 890 7 22 22 CD cord-010119-t1x9gknd 890 8 patient patient NN cord-010119-t1x9gknd 890 9 samples sample NNS cord-010119-t1x9gknd 890 10 over over IN cord-010119-t1x9gknd 890 11 15 15 CD cord-010119-t1x9gknd 890 12 months month NNS cord-010119-t1x9gknd 890 13 . . . cord-010119-t1x9gknd 891 1 Of of IN cord-010119-t1x9gknd 891 2 these these DT cord-010119-t1x9gknd 891 3 22 22 CD cord-010119-t1x9gknd 891 4 patient patient NN cord-010119-t1x9gknd 891 5 samples sample NNS cord-010119-t1x9gknd 891 6 , , , cord-010119-t1x9gknd 891 7 13 13 CD cord-010119-t1x9gknd 891 8 ( ( -LRB- cord-010119-t1x9gknd 891 9 59 59 CD cord-010119-t1x9gknd 891 10 % % NN cord-010119-t1x9gknd 891 11 ) ) -RRB- cord-010119-t1x9gknd 891 12 were be VBD cord-010119-t1x9gknd 891 13 weak weak JJ cord-010119-t1x9gknd 891 14 D d NN cord-010119-t1x9gknd 891 15 types type NNS cord-010119-t1x9gknd 891 16 1 1 CD cord-010119-t1x9gknd 891 17 or or CC cord-010119-t1x9gknd 891 18 2 2 CD cord-010119-t1x9gknd 891 19 . . . cord-010119-t1x9gknd 892 1 The the DT cord-010119-t1x9gknd 892 2 remaining remain VBG cord-010119-t1x9gknd 892 3 samples sample NNS cord-010119-t1x9gknd 892 4 demonstrated demonstrate VBD cord-010119-t1x9gknd 892 5 a a DT cord-010119-t1x9gknd 892 6 variety variety NN cord-010119-t1x9gknd 892 7 of of IN cord-010119-t1x9gknd 892 8 alleles allele NNS cord-010119-t1x9gknd 892 9 including include VBG cord-010119-t1x9gknd 892 10 known know VBN cord-010119-t1x9gknd 892 11 partial partial JJ cord-010119-t1x9gknd 892 12 D d NN cord-010119-t1x9gknd 892 13 variants variant NNS cord-010119-t1x9gknd 892 14 ( ( -LRB- cord-010119-t1x9gknd 892 15 see see VB cord-010119-t1x9gknd 892 16 Table table NN cord-010119-t1x9gknd 892 17 ) ) -RRB- cord-010119-t1x9gknd 892 18 . . . cord-010119-t1x9gknd 893 1 One one CD cord-010119-t1x9gknd 893 2 patient patient NN cord-010119-t1x9gknd 893 3 identified identify VBN cord-010119-t1x9gknd 893 4 as as IN cord-010119-t1x9gknd 893 5 weak weak JJ cord-010119-t1x9gknd 893 6 D d NN cord-010119-t1x9gknd 893 7 type type NN cord-010119-t1x9gknd 893 8 1 1 CD cord-010119-t1x9gknd 893 9 required require VBD cord-010119-t1x9gknd 893 10 multiple multiple JJ cord-010119-t1x9gknd 893 11 transfusions transfusion NNS cord-010119-t1x9gknd 893 12 over over IN cord-010119-t1x9gknd 893 13 the the DT cord-010119-t1x9gknd 893 14 study study NN cord-010119-t1x9gknd 893 15 period period NN cord-010119-t1x9gknd 893 16 , , , cord-010119-t1x9gknd 893 17 and and CC cord-010119-t1x9gknd 893 18 refused refuse VBD cord-010119-t1x9gknd 893 19 RhD rhd NN cord-010119-t1x9gknd 893 20 - - HYPH cord-010119-t1x9gknd 893 21 positive positive JJ cord-010119-t1x9gknd 893 22 RBCs rbc NNS cord-010119-t1x9gknd 893 23 . . . cord-010119-t1x9gknd 894 1 The the DT cord-010119-t1x9gknd 894 2 remaining remain VBG cord-010119-t1x9gknd 894 3 weak weak JJ cord-010119-t1x9gknd 894 4 D d NN cord-010119-t1x9gknd 894 5 types type NNS cord-010119-t1x9gknd 894 6 1 1 CD cord-010119-t1x9gknd 894 7 and and CC cord-010119-t1x9gknd 894 8 2 2 CD cord-010119-t1x9gknd 894 9 patients patient NNS cord-010119-t1x9gknd 894 10 have have VBP cord-010119-t1x9gknd 894 11 not not RB cord-010119-t1x9gknd 894 12 received receive VBN cord-010119-t1x9gknd 894 13 transfusions transfusion NNS cord-010119-t1x9gknd 894 14 at at IN cord-010119-t1x9gknd 894 15 this this DT cord-010119-t1x9gknd 894 16 institution institution NN cord-010119-t1x9gknd 894 17 since since IN cord-010119-t1x9gknd 894 18 they -PRON- PRP cord-010119-t1x9gknd 894 19 were be VBD cord-010119-t1x9gknd 894 20 genotyped genotype VBN cord-010119-t1x9gknd 894 21 . . . cord-010119-t1x9gknd 895 1 Four four CD cord-010119-t1x9gknd 895 2 of of IN cord-010119-t1x9gknd 895 3 4 4 CD cord-010119-t1x9gknd 895 4 obstetric obstetric JJ cord-010119-t1x9gknd 895 5 weak weak JJ cord-010119-t1x9gknd 895 6 D d NN cord-010119-t1x9gknd 895 7 types type NNS cord-010119-t1x9gknd 895 8 1 1 CD cord-010119-t1x9gknd 895 9 and and CC cord-010119-t1x9gknd 895 10 2 2 CD cord-010119-t1x9gknd 895 11 patients patient NNS cord-010119-t1x9gknd 895 12 received receive VBD cord-010119-t1x9gknd 895 13 RhIG rhig NN cord-010119-t1x9gknd 895 14 while while IN cord-010119-t1x9gknd 895 15 genotyping genotyping NN cord-010119-t1x9gknd 895 16 was be VBD cord-010119-t1x9gknd 895 17 pending pende VBG cord-010119-t1x9gknd 895 18 . . . cord-010119-t1x9gknd 896 1 Conclusion conclusion NN cord-010119-t1x9gknd 896 2 : : : cord-010119-t1x9gknd 896 3 Testing testing NN cord-010119-t1x9gknd 896 4 and and CC cord-010119-t1x9gknd 896 5 management management NN cord-010119-t1x9gknd 896 6 of of IN cord-010119-t1x9gknd 896 7 patients patient NNS cord-010119-t1x9gknd 896 8 with with IN cord-010119-t1x9gknd 896 9 serologic serologic JJ cord-010119-t1x9gknd 896 10 weak weak JJ cord-010119-t1x9gknd 896 11 D d NN cord-010119-t1x9gknd 896 12 phenotypes phenotype NNS cord-010119-t1x9gknd 897 1 is be VBZ cord-010119-t1x9gknd 897 2 not not RB cord-010119-t1x9gknd 897 3 standardized standardize VBN cord-010119-t1x9gknd 897 4 . . . cord-010119-t1x9gknd 898 1 RHD RHD NNP cord-010119-t1x9gknd 898 2 genotyping genotyping NN cord-010119-t1x9gknd 898 3 may may MD cord-010119-t1x9gknd 898 4 lead lead VB cord-010119-t1x9gknd 898 5 to to IN cord-010119-t1x9gknd 898 6 more more RBR cord-010119-t1x9gknd 898 7 consistent consistent JJ cord-010119-t1x9gknd 898 8 , , , cord-010119-t1x9gknd 898 9 personalized personalized JJ cord-010119-t1x9gknd 898 10 patient patient NN cord-010119-t1x9gknd 898 11 care care NN cord-010119-t1x9gknd 898 12 and and CC cord-010119-t1x9gknd 898 13 appropriate appropriate JJ cord-010119-t1x9gknd 898 14 management management NN cord-010119-t1x9gknd 898 15 of of IN cord-010119-t1x9gknd 898 16 resources resource NNS cord-010119-t1x9gknd 898 17 . . . cord-010119-t1x9gknd 899 1 In in IN cord-010119-t1x9gknd 899 2 this this DT cord-010119-t1x9gknd 899 3 15 15 CD cord-010119-t1x9gknd 899 4 month month NN cord-010119-t1x9gknd 899 5 study study NN cord-010119-t1x9gknd 899 6 period period NN cord-010119-t1x9gknd 899 7 13 13 CD cord-010119-t1x9gknd 899 8 serologic serologic JJ cord-010119-t1x9gknd 899 9 weak weak JJ cord-010119-t1x9gknd 899 10 D D NNP cord-010119-t1x9gknd 899 11 patients patient NNS cord-010119-t1x9gknd 899 12 were be VBD cord-010119-t1x9gknd 899 13 identified identify VBN cord-010119-t1x9gknd 899 14 who who WP cord-010119-t1x9gknd 899 15 could could MD cord-010119-t1x9gknd 899 16 be be VB cord-010119-t1x9gknd 899 17 managed manage VBN cord-010119-t1x9gknd 899 18 as as IN cord-010119-t1x9gknd 899 19 RhD rhd NN cord-010119-t1x9gknd 899 20 - - HYPH cord-010119-t1x9gknd 899 21 positive positive JJ cord-010119-t1x9gknd 899 22 , , , cord-010119-t1x9gknd 899 23 however however RB cord-010119-t1x9gknd 899 24 this this DT cord-010119-t1x9gknd 899 25 did do VBD cord-010119-t1x9gknd 899 26 not not RB cord-010119-t1x9gknd 899 27 result result VB cord-010119-t1x9gknd 899 28 in in IN cord-010119-t1x9gknd 899 29 withholding withhold VBG cord-010119-t1x9gknd 899 30 any any DT cord-010119-t1x9gknd 899 31 doses dose NNS cord-010119-t1x9gknd 899 32 of of IN cord-010119-t1x9gknd 899 33 RhIG rhig NN cord-010119-t1x9gknd 899 34 nor nor CC cord-010119-t1x9gknd 899 35 conservation conservation NN cord-010119-t1x9gknd 899 36 of of IN cord-010119-t1x9gknd 899 37 RhD rhd NN cord-010119-t1x9gknd 899 38 - - HYPH cord-010119-t1x9gknd 899 39 negative negative JJ cord-010119-t1x9gknd 899 40 RBCs rbc NNS cord-010119-t1x9gknd 899 41 . . . cord-010119-t1x9gknd 900 1 Genotyping genotyping NN cord-010119-t1x9gknd 900 2 results result NNS cord-010119-t1x9gknd 900 3 pertaining pertain VBG cord-010119-t1x9gknd 900 4 to to IN cord-010119-t1x9gknd 900 5 the the DT cord-010119-t1x9gknd 900 6 management management NN cord-010119-t1x9gknd 900 7 of of IN cord-010119-t1x9gknd 900 8 an an DT cord-010119-t1x9gknd 900 9 obstetric obstetric JJ cord-010119-t1x9gknd 900 10 patient patient NN cord-010119-t1x9gknd 900 11 were be VBD cord-010119-t1x9gknd 900 12 discussed discuss VBN cord-010119-t1x9gknd 900 13 with with IN cord-010119-t1x9gknd 900 14 each each DT cord-010119-t1x9gknd 900 15 obstetrician obstetrician NN cord-010119-t1x9gknd 900 16 and and CC cord-010119-t1x9gknd 900 17 it -PRON- PRP cord-010119-t1x9gknd 900 18 is be VBZ cord-010119-t1x9gknd 900 19 possible possible JJ cord-010119-t1x9gknd 900 20 this this DT cord-010119-t1x9gknd 900 21 information information NN cord-010119-t1x9gknd 900 22 may may MD cord-010119-t1x9gknd 900 23 impact impact VB cord-010119-t1x9gknd 900 24 management management NN cord-010119-t1x9gknd 900 25 of of IN cord-010119-t1x9gknd 900 26 future future JJ cord-010119-t1x9gknd 900 27 pregnancies pregnancy NNS cord-010119-t1x9gknd 900 28 . . . cord-010119-t1x9gknd 901 1 These these DT cord-010119-t1x9gknd 901 2 outcomes outcome NNS cord-010119-t1x9gknd 901 3 highlight highlight VBP cord-010119-t1x9gknd 901 4 the the DT cord-010119-t1x9gknd 901 5 limitations limitation NNS cord-010119-t1x9gknd 901 6 of of IN cord-010119-t1x9gknd 901 7 current current JJ cord-010119-t1x9gknd 901 8 genotyping genotyping NN cord-010119-t1x9gknd 901 9 processes process NNS cord-010119-t1x9gknd 901 10 , , , cord-010119-t1x9gknd 901 11 including include VBG cord-010119-t1x9gknd 901 12 long long JJ cord-010119-t1x9gknd 901 13 turn turn NN cord-010119-t1x9gknd 901 14 - - HYPH cord-010119-t1x9gknd 901 15 around around IN cord-010119-t1x9gknd 901 16 - - HYPH cord-010119-t1x9gknd 901 17 time time NN cord-010119-t1x9gknd 901 18 Background Background NNP cord-010119-t1x9gknd 901 19 / / SYM cord-010119-t1x9gknd 901 20 Case Case NNP cord-010119-t1x9gknd 901 21 Studies Studies NNPS cord-010119-t1x9gknd 901 22 : : : cord-010119-t1x9gknd 901 23 The the DT cord-010119-t1x9gknd 901 24 RH RH NNP cord-010119-t1x9gknd 901 25 blood blood NN cord-010119-t1x9gknd 901 26 group group NN cord-010119-t1x9gknd 901 27 is be VBZ cord-010119-t1x9gknd 901 28 highly highly RB cord-010119-t1x9gknd 901 29 immunogenic immunogenic JJ cord-010119-t1x9gknd 901 30 and and CC cord-010119-t1x9gknd 901 31 the the DT cord-010119-t1x9gknd 901 32 most most RBS cord-010119-t1x9gknd 901 33 clinically clinically RB cord-010119-t1x9gknd 901 34 significant significant JJ cord-010119-t1x9gknd 901 35 blood blood NN cord-010119-t1x9gknd 901 36 group group NN cord-010119-t1x9gknd 901 37 secondary secondary JJ cord-010119-t1x9gknd 901 38 only only RB cord-010119-t1x9gknd 901 39 to to IN cord-010119-t1x9gknd 901 40 ABO ABO NNP cord-010119-t1x9gknd 901 41 . . . cord-010119-t1x9gknd 902 1 Currently currently RB cord-010119-t1x9gknd 902 2 , , , cord-010119-t1x9gknd 902 3 in in IN cord-010119-t1x9gknd 902 4 the the DT cord-010119-t1x9gknd 902 5 United United NNP cord-010119-t1x9gknd 902 6 States States NNP cord-010119-t1x9gknd 902 7 , , , cord-010119-t1x9gknd 902 8 blood blood NN cord-010119-t1x9gknd 902 9 donors donor NNS cord-010119-t1x9gknd 902 10 who who WP cord-010119-t1x9gknd 902 11 type type VBP cord-010119-t1x9gknd 902 12 RhD rhd NN cord-010119-t1x9gknd 902 13 - - HYPH cord-010119-t1x9gknd 902 14 negative negative JJ cord-010119-t1x9gknd 902 15 by by IN cord-010119-t1x9gknd 902 16 serology serology NN cord-010119-t1x9gknd 902 17 undergo undergo VBP cord-010119-t1x9gknd 902 18 weak weak JJ cord-010119-t1x9gknd 902 19 - - HYPH cord-010119-t1x9gknd 902 20 D d JJ cord-010119-t1x9gknd 902 21 testing testing NN cord-010119-t1x9gknd 902 22 to to TO cord-010119-t1x9gknd 902 23 identify identify VB cord-010119-t1x9gknd 902 24 some some DT cord-010119-t1x9gknd 902 25 weak weak JJ cord-010119-t1x9gknd 902 26 and and CC cord-010119-t1x9gknd 902 27 partial partial JJ cord-010119-t1x9gknd 902 28 states state NNS cord-010119-t1x9gknd 902 29 of of IN cord-010119-t1x9gknd 902 30 RhD RhD NNP cord-010119-t1x9gknd 902 31 expression expression NN cord-010119-t1x9gknd 902 32 . . . cord-010119-t1x9gknd 903 1 However however RB cord-010119-t1x9gknd 903 2 , , , cord-010119-t1x9gknd 903 3 not not RB cord-010119-t1x9gknd 903 4 all all DT cord-010119-t1x9gknd 903 5 RhD rhd NN cord-010119-t1x9gknd 903 6 expression expression NN cord-010119-t1x9gknd 903 7 can can MD cord-010119-t1x9gknd 903 8 be be VB cord-010119-t1x9gknd 903 9 detected detect VBN cord-010119-t1x9gknd 903 10 serologically serologically RB cord-010119-t1x9gknd 903 11 . . . cord-010119-t1x9gknd 904 1 It -PRON- PRP cord-010119-t1x9gknd 904 2 has have VBZ cord-010119-t1x9gknd 904 3 been be VBN cord-010119-t1x9gknd 904 4 suggested suggest VBN cord-010119-t1x9gknd 904 5 that that IN cord-010119-t1x9gknd 904 6 investigation investigation NN cord-010119-t1x9gknd 904 7 of of IN cord-010119-t1x9gknd 904 8 serologic serologic NNP cord-010119-t1x9gknd 904 9 RhD RhD NNP cord-010119-t1x9gknd 904 10 - - HYPH cord-010119-t1x9gknd 904 11 negative negative JJ cord-010119-t1x9gknd 904 12 blood blood NN cord-010119-t1x9gknd 904 13 donors donor NNS cord-010119-t1x9gknd 904 14 using use VBG cord-010119-t1x9gknd 904 15 genotyping genotyping NN cord-010119-t1x9gknd 904 16 methods method NNS cord-010119-t1x9gknd 904 17 can can MD cord-010119-t1x9gknd 904 18 more more RBR cord-010119-t1x9gknd 904 19 accurately accurately RB cord-010119-t1x9gknd 904 20 identify identify VB cord-010119-t1x9gknd 904 21 units unit NNS cord-010119-t1x9gknd 904 22 that that WDT cord-010119-t1x9gknd 904 23 may may MD cord-010119-t1x9gknd 904 24 lead lead VB cord-010119-t1x9gknd 904 25 to to IN cord-010119-t1x9gknd 904 26 alloimmunization alloimmunization NN cord-010119-t1x9gknd 904 27 in in IN cord-010119-t1x9gknd 904 28 RhD rhd NN cord-010119-t1x9gknd 904 29 - - HYPH cord-010119-t1x9gknd 904 30 negative negative JJ cord-010119-t1x9gknd 904 31 recipients recipient NNS cord-010119-t1x9gknd 904 32 . . . cord-010119-t1x9gknd 905 1 Study Study NNP cord-010119-t1x9gknd 905 2 Design Design NNP cord-010119-t1x9gknd 905 3 / / SYM cord-010119-t1x9gknd 905 4 Method method NN cord-010119-t1x9gknd 905 5 : : : cord-010119-t1x9gknd 906 1 RHD RHD NNP cord-010119-t1x9gknd 906 2 genotyping genotyping NN cord-010119-t1x9gknd 906 3 of of IN cord-010119-t1x9gknd 906 4 all all DT cord-010119-t1x9gknd 906 5 serologic serologic NNP cord-010119-t1x9gknd 906 6 RhD rhd NN cord-010119-t1x9gknd 906 7 - - HYPH cord-010119-t1x9gknd 906 8 negative negative JJ cord-010119-t1x9gknd 906 9 blood blood NN cord-010119-t1x9gknd 906 10 donors donor NNS cord-010119-t1x9gknd 906 11 presenting present VBG cord-010119-t1x9gknd 906 12 to to IN cord-010119-t1x9gknd 906 13 our -PRON- PRP$ cord-010119-t1x9gknd 906 14 blood blood NN cord-010119-t1x9gknd 906 15 donor donor NN cord-010119-t1x9gknd 906 16 center center NN cord-010119-t1x9gknd 906 17 was be VBD cord-010119-t1x9gknd 906 18 implemented implement VBN cord-010119-t1x9gknd 906 19 to to TO cord-010119-t1x9gknd 906 20 identify identify VB cord-010119-t1x9gknd 906 21 units unit NNS cord-010119-t1x9gknd 906 22 with with IN cord-010119-t1x9gknd 906 23 altered altered JJ cord-010119-t1x9gknd 906 24 RHD RHD NNP cord-010119-t1x9gknd 906 25 alleles allele NNS cord-010119-t1x9gknd 906 26 that that WDT cord-010119-t1x9gknd 906 27 should should MD cord-010119-t1x9gknd 906 28 be be VB cord-010119-t1x9gknd 906 29 characterized characterize VBN cord-010119-t1x9gknd 906 30 as as IN cord-010119-t1x9gknd 906 31 RhDpositive RhDpositive NNP cord-010119-t1x9gknd 906 32 . . . cord-010119-t1x9gknd 907 1 Repeat repeat NN cord-010119-t1x9gknd 907 2 donations donation NNS cord-010119-t1x9gknd 907 3 were be VBD cord-010119-t1x9gknd 907 4 not not RB cord-010119-t1x9gknd 907 5 tested test VBN cord-010119-t1x9gknd 907 6 . . . cord-010119-t1x9gknd 908 1 Initial initial JJ cord-010119-t1x9gknd 908 2 serologic serologic NN cord-010119-t1x9gknd 908 3 testing testing NN cord-010119-t1x9gknd 908 4 of of IN cord-010119-t1x9gknd 908 5 blood blood NN cord-010119-t1x9gknd 908 6 donors donor NNS cord-010119-t1x9gknd 908 7 was be VBD cord-010119-t1x9gknd 908 8 performed perform VBN cord-010119-t1x9gknd 908 9 using use VBG cord-010119-t1x9gknd 908 10 3 3 CD cord-010119-t1x9gknd 908 11 FDA FDA NNP cord-010119-t1x9gknd 908 12 approved approve VBN cord-010119-t1x9gknd 908 13 anti anti JJ cord-010119-t1x9gknd 908 14 - - JJ cord-010119-t1x9gknd 908 15 D d JJ cord-010119-t1x9gknd 908 16 reagents reagent NNS cord-010119-t1x9gknd 908 17 . . . cord-010119-t1x9gknd 909 1 When when WRB cord-010119-t1x9gknd 909 2 reactivity reactivity NN cord-010119-t1x9gknd 909 3 with with IN cord-010119-t1x9gknd 909 4 all all DT cord-010119-t1x9gknd 909 5 3 3 CD cord-010119-t1x9gknd 909 6 reagents reagent NNS cord-010119-t1x9gknd 909 7 was be VBD cord-010119-t1x9gknd 909 8 negative negative JJ cord-010119-t1x9gknd 909 9 , , , cord-010119-t1x9gknd 909 10 RHD RHD NNP cord-010119-t1x9gknd 909 11 genotyping genotyping NN cord-010119-t1x9gknd 909 12 was be VBD cord-010119-t1x9gknd 909 13 performed perform VBN cord-010119-t1x9gknd 909 14 using use VBG cord-010119-t1x9gknd 909 15 a a DT cord-010119-t1x9gknd 909 16 commercially commercially RB cord-010119-t1x9gknd 909 17 available available JJ cord-010119-t1x9gknd 909 18 genotyping genotyping NN cord-010119-t1x9gknd 909 19 kit kit NN cord-010119-t1x9gknd 909 20 manufactured manufacture VBN cord-010119-t1x9gknd 909 21 by by IN cord-010119-t1x9gknd 909 22 Immucor Immucor NNP cord-010119-t1x9gknd 909 23 ( ( -LRB- cord-010119-t1x9gknd 909 24 RHD RHD NNP cord-010119-t1x9gknd 909 25 BeadChip BeadChip NNP cord-010119-t1x9gknd 909 26 ) ) -RRB- cord-010119-t1x9gknd 909 27 . . . cord-010119-t1x9gknd 910 1 This this DT cord-010119-t1x9gknd 910 2 assay assay NN cord-010119-t1x9gknd 910 3 detects detect VBZ cord-010119-t1x9gknd 910 4 over over IN cord-010119-t1x9gknd 910 5 80 80 CD cord-010119-t1x9gknd 910 6 RHD RHD NNP cord-010119-t1x9gknd 910 7 variant variant NN cord-010119-t1x9gknd 910 8 alleles allele NNS cord-010119-t1x9gknd 910 9 and and CC cord-010119-t1x9gknd 910 10 additional additional JJ cord-010119-t1x9gknd 910 11 DNA dna NN cord-010119-t1x9gknd 910 12 sequencing sequencing NN cord-010119-t1x9gknd 910 13 was be VBD cord-010119-t1x9gknd 910 14 performed perform VBN cord-010119-t1x9gknd 910 15 in in IN cord-010119-t1x9gknd 910 16 selected select VBN cord-010119-t1x9gknd 910 17 cases case NNS cord-010119-t1x9gknd 910 18 . . . cord-010119-t1x9gknd 911 1 To to TO cord-010119-t1x9gknd 911 2 maximize maximize VB cord-010119-t1x9gknd 911 3 efficiency efficiency NN cord-010119-t1x9gknd 911 4 samples sample NNS cord-010119-t1x9gknd 911 5 were be VBD cord-010119-t1x9gknd 911 6 batched batch VBN cord-010119-t1x9gknd 911 7 for for IN cord-010119-t1x9gknd 911 8 testing testing NN cord-010119-t1x9gknd 911 9 ; ; : cord-010119-t1x9gknd 911 10 testing testing NN cord-010119-t1x9gknd 911 11 was be VBD cord-010119-t1x9gknd 911 12 generally generally RB cord-010119-t1x9gknd 911 13 performed perform VBN cord-010119-t1x9gknd 911 14 once once RB cord-010119-t1x9gknd 911 15 a a DT cord-010119-t1x9gknd 911 16 month month NN cord-010119-t1x9gknd 911 17 . . . cord-010119-t1x9gknd 912 1 If if IN cord-010119-t1x9gknd 912 2 an an DT cord-010119-t1x9gknd 912 3 RHD RHD NNP cord-010119-t1x9gknd 912 4 variant variant NN cord-010119-t1x9gknd 912 5 known know VBN cord-010119-t1x9gknd 912 6 or or CC cord-010119-t1x9gknd 912 7 suspected suspect VBN cord-010119-t1x9gknd 912 8 to to TO cord-010119-t1x9gknd 912 9 be be VB cord-010119-t1x9gknd 912 10 associated associate VBN cord-010119-t1x9gknd 912 11 with with IN cord-010119-t1x9gknd 912 12 an an DT cord-010119-t1x9gknd 912 13 increased increase VBN cord-010119-t1x9gknd 912 14 risk risk NN cord-010119-t1x9gknd 912 15 of of IN cord-010119-t1x9gknd 912 16 alloimmunization alloimmunization NN cord-010119-t1x9gknd 912 17 was be VBD cord-010119-t1x9gknd 912 18 detected detect VBN cord-010119-t1x9gknd 912 19 , , , cord-010119-t1x9gknd 912 20 recipients recipient NNS cord-010119-t1x9gknd 912 21 of of IN cord-010119-t1x9gknd 912 22 previous previous JJ cord-010119-t1x9gknd 912 23 donations donation NNS cord-010119-t1x9gknd 912 24 were be VBD cord-010119-t1x9gknd 912 25 investigated investigate VBN cord-010119-t1x9gknd 912 26 for for IN cord-010119-t1x9gknd 912 27 evidence evidence NN cord-010119-t1x9gknd 912 28 of of IN cord-010119-t1x9gknd 912 29 alloimmunization alloimmunization NN cord-010119-t1x9gknd 912 30 , , , cord-010119-t1x9gknd 912 31 and and CC cord-010119-t1x9gknd 912 32 all all DT cord-010119-t1x9gknd 912 33 future future JJ cord-010119-t1x9gknd 912 34 donations donation NNS cord-010119-t1x9gknd 912 35 were be VBD cord-010119-t1x9gknd 912 36 restricted restrict VBN cord-010119-t1x9gknd 912 37 to to IN cord-010119-t1x9gknd 912 38 RhD rhd NN cord-010119-t1x9gknd 912 39 - - HYPH cord-010119-t1x9gknd 912 40 positive positive JJ cord-010119-t1x9gknd 912 41 recipients recipient NNS cord-010119-t1x9gknd 912 42 . . . cord-010119-t1x9gknd 913 1 Results result NNS cord-010119-t1x9gknd 913 2 / / SYM cord-010119-t1x9gknd 913 3 Finding finding NN cord-010119-t1x9gknd 913 4 : : : cord-010119-t1x9gknd 913 5 Over over IN cord-010119-t1x9gknd 913 6 a a DT cord-010119-t1x9gknd 913 7 period period NN cord-010119-t1x9gknd 913 8 of of IN cord-010119-t1x9gknd 913 9 8 8 CD cord-010119-t1x9gknd 913 10 months month NNS cord-010119-t1x9gknd 913 11 we -PRON- PRP cord-010119-t1x9gknd 913 12 tested test VBD cord-010119-t1x9gknd 913 13 509 509 CD cord-010119-t1x9gknd 913 14 RhD rhd NN cord-010119-t1x9gknd 913 15 - - HYPH cord-010119-t1x9gknd 913 16 negative negative JJ cord-010119-t1x9gknd 913 17 blood blood NN cord-010119-t1x9gknd 913 18 donors donor NNS cord-010119-t1x9gknd 913 19 . . . cord-010119-t1x9gknd 914 1 There there EX cord-010119-t1x9gknd 914 2 were be VBD cord-010119-t1x9gknd 914 3 3 3 CD cord-010119-t1x9gknd 914 4 ( ( -LRB- cord-010119-t1x9gknd 914 5 0.6 0.6 CD cord-010119-t1x9gknd 914 6 % % NN cord-010119-t1x9gknd 914 7 ) ) -RRB- cord-010119-t1x9gknd 914 8 partial partial JJ cord-010119-t1x9gknd 914 9 - - HYPH cord-010119-t1x9gknd 914 10 D d JJ cord-010119-t1x9gknd 914 11 , , , cord-010119-t1x9gknd 914 12 1 1 CD cord-010119-t1x9gknd 914 13 weak weak JJ cord-010119-t1x9gknd 914 14 D d NN cord-010119-t1x9gknd 914 15 ( ( -LRB- cord-010119-t1x9gknd 914 16 0.2 0.2 CD cord-010119-t1x9gknd 914 17 % % NN cord-010119-t1x9gknd 914 18 ) ) -RRB- cord-010119-t1x9gknd 914 19 , , , cord-010119-t1x9gknd 914 20 and and CC cord-010119-t1x9gknd 914 21 3 3 CD cord-010119-t1x9gknd 914 22 ( ( -LRB- cord-010119-t1x9gknd 914 23 0.6 0.6 CD cord-010119-t1x9gknd 914 24 % % NN cord-010119-t1x9gknd 914 25 ) ) -RRB- cord-010119-t1x9gknd 914 26 DEL DEL NNP cord-010119-t1x9gknd 914 27 donors donor NNS cord-010119-t1x9gknd 914 28 . . . cord-010119-t1x9gknd 915 1 In in IN cord-010119-t1x9gknd 915 2 one one CD cord-010119-t1x9gknd 915 3 donor donor NN cord-010119-t1x9gknd 915 4 sample sample NN cord-010119-t1x9gknd 915 5 a a DT cord-010119-t1x9gknd 915 6 novel novel JJ cord-010119-t1x9gknd 915 7 RhD rhd NN cord-010119-t1x9gknd 915 8 allele allele NN cord-010119-t1x9gknd 915 9 was be VBD cord-010119-t1x9gknd 915 10 identified identify VBN cord-010119-t1x9gknd 915 11 through through IN cord-010119-t1x9gknd 915 12 DNA dna NN cord-010119-t1x9gknd 915 13 sequencing sequencing NN cord-010119-t1x9gknd 915 14 ( ( -LRB- cord-010119-t1x9gknd 915 15 RHD*IVS5 RHD*IVS5 VBN cord-010119-t1x9gknd 915 16 - - HYPH cord-010119-t1x9gknd 915 17 46_42delTCTC 46_42deltctc CD cord-010119-t1x9gknd 915 18 ) ) -RRB- cord-010119-t1x9gknd 915 19 . . . cord-010119-t1x9gknd 916 1 The the DT cord-010119-t1x9gknd 916 2 phenotype phenotype NN cord-010119-t1x9gknd 916 3 associated associate VBN cord-010119-t1x9gknd 916 4 with with IN cord-010119-t1x9gknd 916 5 this this DT cord-010119-t1x9gknd 916 6 allele allele NN cord-010119-t1x9gknd 916 7 variant variant NN cord-010119-t1x9gknd 916 8 is be VBZ cord-010119-t1x9gknd 916 9 unknown unknown JJ cord-010119-t1x9gknd 916 10 . . . cord-010119-t1x9gknd 917 1 Investigation investigation NN cord-010119-t1x9gknd 917 2 of of IN cord-010119-t1x9gknd 917 3 previous previous JJ cord-010119-t1x9gknd 917 4 donations donation NNS cord-010119-t1x9gknd 917 5 from from IN cord-010119-t1x9gknd 917 6 these these DT cord-010119-t1x9gknd 917 7 8 8 CD cord-010119-t1x9gknd 917 8 donors donor NNS cord-010119-t1x9gknd 917 9 showed show VBD cord-010119-t1x9gknd 917 10 that that IN cord-010119-t1x9gknd 917 11 6 6 CD cord-010119-t1x9gknd 917 12 RhD rhd NN cord-010119-t1x9gknd 917 13 - - HYPH cord-010119-t1x9gknd 917 14 negative negative JJ cord-010119-t1x9gknd 917 15 recipients recipient NNS cord-010119-t1x9gknd 917 16 received receive VBD cord-010119-t1x9gknd 917 17 RBCs rbc NNS cord-010119-t1x9gknd 917 18 from from IN cord-010119-t1x9gknd 917 19 4 4 CD cord-010119-t1x9gknd 917 20 of of IN cord-010119-t1x9gknd 917 21 these these DT cord-010119-t1x9gknd 917 22 donors donor NNS cord-010119-t1x9gknd 917 23 . . . cord-010119-t1x9gknd 918 1 Five five CD cord-010119-t1x9gknd 918 2 of of IN cord-010119-t1x9gknd 918 3 these these DT cord-010119-t1x9gknd 918 4 recipients recipient NNS cord-010119-t1x9gknd 918 5 underwent undergo VBD cord-010119-t1x9gknd 918 6 antibody antibody NN cord-010119-t1x9gknd 918 7 screening screening NN cord-010119-t1x9gknd 918 8 after after IN cord-010119-t1x9gknd 918 9 an an DT cord-010119-t1x9gknd 918 10 average average JJ cord-010119-t1x9gknd 918 11 follow follow NN cord-010119-t1x9gknd 918 12 - - HYPH cord-010119-t1x9gknd 918 13 up up NN cord-010119-t1x9gknd 918 14 period period NN cord-010119-t1x9gknd 918 15 of of IN cord-010119-t1x9gknd 918 16 5 5 CD cord-010119-t1x9gknd 918 17 months month NNS cord-010119-t1x9gknd 918 18 ; ; : cord-010119-t1x9gknd 918 19 anti anti JJ cord-010119-t1x9gknd 918 20 - - JJ cord-010119-t1x9gknd 918 21 D d JJ cord-010119-t1x9gknd 918 22 was be VBD cord-010119-t1x9gknd 918 23 not not RB cord-010119-t1x9gknd 918 24 detected detect VBN cord-010119-t1x9gknd 918 25 in in IN cord-010119-t1x9gknd 918 26 any any DT cord-010119-t1x9gknd 918 27 sample sample NN cord-010119-t1x9gknd 918 28 ( ( -LRB- cord-010119-t1x9gknd 918 29 See see VB cord-010119-t1x9gknd 918 30 Table table NN cord-010119-t1x9gknd 918 31 ) ) -RRB- cord-010119-t1x9gknd 918 32 . . . cord-010119-t1x9gknd 919 1 Conclusion conclusion NN cord-010119-t1x9gknd 919 2 : : : cord-010119-t1x9gknd 919 3 Serologic Serologic NNP cord-010119-t1x9gknd 919 4 testing testing NN cord-010119-t1x9gknd 919 5 occasionally occasionally RB cord-010119-t1x9gknd 919 6 fails fail VBZ cord-010119-t1x9gknd 919 7 to to TO cord-010119-t1x9gknd 919 8 identify identify VB cord-010119-t1x9gknd 919 9 some some DT cord-010119-t1x9gknd 919 10 RhDpositive rhdpositive JJ cord-010119-t1x9gknd 919 11 donor donor NN cord-010119-t1x9gknd 919 12 units unit NNS cord-010119-t1x9gknd 919 13 , , , cord-010119-t1x9gknd 919 14 which which WDT cord-010119-t1x9gknd 919 15 could could MD cord-010119-t1x9gknd 919 16 place place VB cord-010119-t1x9gknd 919 17 RhD rhd NN cord-010119-t1x9gknd 919 18 - - HYPH cord-010119-t1x9gknd 919 19 negative negative JJ cord-010119-t1x9gknd 919 20 recipients recipient NNS cord-010119-t1x9gknd 919 21 at at IN cord-010119-t1x9gknd 919 22 risk risk NN cord-010119-t1x9gknd 919 23 for for IN cord-010119-t1x9gknd 919 24 alloimmunization alloimmunization NN cord-010119-t1x9gknd 919 25 . . . cord-010119-t1x9gknd 920 1 DNA dna NN cord-010119-t1x9gknd 920 2 - - HYPH cord-010119-t1x9gknd 920 3 based base VBN cord-010119-t1x9gknd 920 4 testing testing NN cord-010119-t1x9gknd 920 5 can can MD cord-010119-t1x9gknd 920 6 be be VB cord-010119-t1x9gknd 920 7 used use VBN cord-010119-t1x9gknd 920 8 to to TO cord-010119-t1x9gknd 920 9 identify identify VB cord-010119-t1x9gknd 920 10 donors donor NNS cord-010119-t1x9gknd 920 11 who who WP cord-010119-t1x9gknd 920 12 have have VBP cord-010119-t1x9gknd 920 13 the the DT cord-010119-t1x9gknd 920 14 potential potential NN cord-010119-t1x9gknd 920 15 to to TO cord-010119-t1x9gknd 920 16 sensitize sensitize VB cord-010119-t1x9gknd 920 17 RhD rhd NN cord-010119-t1x9gknd 920 18 - - HYPH cord-010119-t1x9gknd 920 19 negative negative JJ cord-010119-t1x9gknd 920 20 individuals individual NNS cord-010119-t1x9gknd 920 21 . . . cord-010119-t1x9gknd 921 1 In in IN cord-010119-t1x9gknd 921 2 this this DT cord-010119-t1x9gknd 921 3 limited limited JJ cord-010119-t1x9gknd 921 4 study study NN cord-010119-t1x9gknd 921 5 period period NN cord-010119-t1x9gknd 921 6 a a DT cord-010119-t1x9gknd 921 7 small small JJ cord-010119-t1x9gknd 921 8 number number NN cord-010119-t1x9gknd 921 9 of of IN cord-010119-t1x9gknd 921 10 serologic serologic NNP cord-010119-t1x9gknd 921 11 RhD rhd NN cord-010119-t1x9gknd 921 12 - - HYPH cord-010119-t1x9gknd 921 13 negative negative JJ cord-010119-t1x9gknd 921 14 donors donor NNS cord-010119-t1x9gknd 921 15 , , , cord-010119-t1x9gknd 921 16 whose whose WP$ cord-010119-t1x9gknd 921 17 genotype genotype NN cord-010119-t1x9gknd 921 18 indicated indicate VBD cord-010119-t1x9gknd 921 19 potential potential NN cord-010119-t1x9gknd 921 20 to to TO cord-010119-t1x9gknd 921 21 sensitize sensitize VB cord-010119-t1x9gknd 921 22 recipients recipient NNS cord-010119-t1x9gknd 921 23 , , , cord-010119-t1x9gknd 921 24 were be VBD cord-010119-t1x9gknd 921 25 found find VBN cord-010119-t1x9gknd 921 26 . . . cord-010119-t1x9gknd 922 1 However however RB cord-010119-t1x9gknd 922 2 , , , cord-010119-t1x9gknd 922 3 review review NN cord-010119-t1x9gknd 922 4 of of IN cord-010119-t1x9gknd 922 5 recipient recipient NN cord-010119-t1x9gknd 922 6 transfusion transfusion NN cord-010119-t1x9gknd 922 7 records record NNS cord-010119-t1x9gknd 922 8 indicated indicate VBD cord-010119-t1x9gknd 922 9 that that IN cord-010119-t1x9gknd 922 10 prior prior JJ cord-010119-t1x9gknd 922 11 exposure exposure NN cord-010119-t1x9gknd 922 12 to to IN cord-010119-t1x9gknd 922 13 these these DT cord-010119-t1x9gknd 922 14 donors donor NNS cord-010119-t1x9gknd 922 15 ' ' POS cord-010119-t1x9gknd 922 16 RBCs rbc NNS cord-010119-t1x9gknd 922 17 did do VBD cord-010119-t1x9gknd 922 18 not not RB cord-010119-t1x9gknd 922 19 lead lead VB cord-010119-t1x9gknd 922 20 to to IN cord-010119-t1x9gknd 922 21 detectable detectable JJ cord-010119-t1x9gknd 922 22 immunization immunization NN cord-010119-t1x9gknd 922 23 to to IN cord-010119-t1x9gknd 922 24 date date NN cord-010119-t1x9gknd 922 25 . . . cord-010119-t1x9gknd 923 1 Future future JJ cord-010119-t1x9gknd 923 2 potential potential JJ cord-010119-t1x9gknd 923 3 sensitizing sensitize VBG cord-010119-t1x9gknd 923 4 events event NNS cord-010119-t1x9gknd 923 5 will will MD cord-010119-t1x9gknd 923 6 be be VB cord-010119-t1x9gknd 923 7 avoided avoid VBN cord-010119-t1x9gknd 923 8 by by IN cord-010119-t1x9gknd 923 9 restricting restrict VBG cord-010119-t1x9gknd 923 10 these these DT cord-010119-t1x9gknd 923 11 units unit NNS cord-010119-t1x9gknd 923 12 to to IN cord-010119-t1x9gknd 923 13 RhD rhd NN cord-010119-t1x9gknd 923 14 - - HYPH cord-010119-t1x9gknd 923 15 positive positive JJ cord-010119-t1x9gknd 923 16 recipients recipient NNS cord-010119-t1x9gknd 923 17 . . . cord-010119-t1x9gknd 924 1 Grifols Grifols NNP cord-010119-t1x9gknd 924 2 Diagnostic Diagnostic NNP cord-010119-t1x9gknd 924 3 Solutions Solutions NNPS cord-010119-t1x9gknd 924 4 Labs Labs NNP cord-010119-t1x9gknd 924 5 , , , cord-010119-t1x9gknd 924 6 5 5 CD cord-010119-t1x9gknd 924 7 Grifols Grifols NNP cord-010119-t1x9gknd 924 8 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 924 9 Center Center NNP cord-010119-t1x9gknd 924 10 Background Background NNP cord-010119-t1x9gknd 924 11 / / SYM cord-010119-t1x9gknd 924 12 Case Case NNP cord-010119-t1x9gknd 924 13 Studies Studies NNPS cord-010119-t1x9gknd 924 14 : : : cord-010119-t1x9gknd 925 1 Pregnant pregnant JJ cord-010119-t1x9gknd 925 2 women woman NNS cord-010119-t1x9gknd 925 3 with with IN cord-010119-t1x9gknd 925 4 RHD RHD NNP cord-010119-t1x9gknd 925 5 variants variant NNS cord-010119-t1x9gknd 925 6 may may MD cord-010119-t1x9gknd 925 7 be be VB cord-010119-t1x9gknd 925 8 candidates candidate NNS cord-010119-t1x9gknd 925 9 for for IN cord-010119-t1x9gknd 925 10 RhIG rhig NN cord-010119-t1x9gknd 925 11 prophylaxis prophylaxis NN cord-010119-t1x9gknd 925 12 if if IN cord-010119-t1x9gknd 925 13 molecular molecular JJ cord-010119-t1x9gknd 925 14 analysis analysis NN cord-010119-t1x9gknd 925 15 reveals reveal VBZ cord-010119-t1x9gknd 925 16 a a DT cord-010119-t1x9gknd 925 17 genotype genotype NN cord-010119-t1x9gknd 925 18 associated associate VBN cord-010119-t1x9gknd 925 19 with with IN cord-010119-t1x9gknd 925 20 possible possible JJ cord-010119-t1x9gknd 925 21 anti anti JJ cord-010119-t1x9gknd 925 22 - - JJ cord-010119-t1x9gknd 925 23 D d JJ cord-010119-t1x9gknd 925 24 formation formation NN cord-010119-t1x9gknd 925 25 . . . cord-010119-t1x9gknd 926 1 Proposed propose VBN cord-010119-t1x9gknd 926 2 testing testing NN cord-010119-t1x9gknd 926 3 algorithms algorithm NNS cord-010119-t1x9gknd 926 4 advocate advocate VBP cord-010119-t1x9gknd 926 5 molecular molecular JJ cord-010119-t1x9gknd 926 6 characterization characterization NN cord-010119-t1x9gknd 926 7 of of IN cord-010119-t1x9gknd 926 8 weak weak JJ cord-010119-t1x9gknd 926 9 D d NN cord-010119-t1x9gknd 926 10 types type NNS cord-010119-t1x9gknd 926 11 but but CC cord-010119-t1x9gknd 926 12 if if IN cord-010119-t1x9gknd 926 13 a a DT cord-010119-t1x9gknd 926 14 patient patient NN cord-010119-t1x9gknd 926 15 types type NNS cord-010119-t1x9gknd 926 16 as as IN cord-010119-t1x9gknd 926 17 RhD rhd NN cord-010119-t1x9gknd 926 18 - - HYPH cord-010119-t1x9gknd 926 19 positive positive JJ cord-010119-t1x9gknd 926 20 , , , cord-010119-t1x9gknd 926 21 no no DT cord-010119-t1x9gknd 926 22 further further JJ cord-010119-t1x9gknd 926 23 action action NN cord-010119-t1x9gknd 926 24 is be VBZ cord-010119-t1x9gknd 926 25 proposed propose VBN cord-010119-t1x9gknd 926 26 . . . cord-010119-t1x9gknd 927 1 Women woman NNS cord-010119-t1x9gknd 927 2 with with IN cord-010119-t1x9gknd 927 3 partial partial JJ cord-010119-t1x9gknd 927 4 D d NN cord-010119-t1x9gknd 927 5 variants variant NNS cord-010119-t1x9gknd 927 6 who who WP cord-010119-t1x9gknd 927 7 may may MD cord-010119-t1x9gknd 927 8 also also RB cord-010119-t1x9gknd 927 9 be be VB cord-010119-t1x9gknd 927 10 at at IN cord-010119-t1x9gknd 927 11 risk risk NN cord-010119-t1x9gknd 927 12 of of IN cord-010119-t1x9gknd 927 13 anti anti JJ cord-010119-t1x9gknd 927 14 - - JJ cord-010119-t1x9gknd 927 15 D d JJ cord-010119-t1x9gknd 927 16 formation formation NN cord-010119-t1x9gknd 927 17 have have VBP cord-010119-t1x9gknd 927 18 not not RB cord-010119-t1x9gknd 927 19 been be VBN cord-010119-t1x9gknd 927 20 included include VBN cord-010119-t1x9gknd 927 21 in in IN cord-010119-t1x9gknd 927 22 algorithms algorithm NNS cord-010119-t1x9gknd 927 23 proposed propose VBN cord-010119-t1x9gknd 927 24 to to IN cord-010119-t1x9gknd 927 25 date date NN cord-010119-t1x9gknd 927 26 yet yet RB cord-010119-t1x9gknd 928 1 molecular molecular JJ cord-010119-t1x9gknd 928 2 testing testing NN cord-010119-t1x9gknd 928 3 may may MD cord-010119-t1x9gknd 928 4 unmask unmask VB cord-010119-t1x9gknd 928 5 this this DT cord-010119-t1x9gknd 928 6 hidden hidden JJ cord-010119-t1x9gknd 928 7 subpopulation subpopulation NN cord-010119-t1x9gknd 928 8 of of IN cord-010119-t1x9gknd 928 9 women woman NNS cord-010119-t1x9gknd 928 10 who who WP cord-010119-t1x9gknd 928 11 type type VBP cord-010119-t1x9gknd 928 12 as as IN cord-010119-t1x9gknd 928 13 D d NN cord-010119-t1x9gknd 928 14 - - HYPH cord-010119-t1x9gknd 928 15 positive positive JJ cord-010119-t1x9gknd 928 16 but but CC cord-010119-t1x9gknd 928 17 who who WP cord-010119-t1x9gknd 928 18 may may MD cord-010119-t1x9gknd 928 19 be be VB cord-010119-t1x9gknd 928 20 candidates candidate NNS cord-010119-t1x9gknd 928 21 for for IN cord-010119-t1x9gknd 928 22 RhIG rhig NN cord-010119-t1x9gknd 928 23 prophylaxis prophylaxis NN cord-010119-t1x9gknd 928 24 . . . cord-010119-t1x9gknd 929 1 Our -PRON- PRP$ cord-010119-t1x9gknd 929 2 hospital hospital NN cord-010119-t1x9gknd 929 3 is be VBZ cord-010119-t1x9gknd 929 4 in in IN cord-010119-t1x9gknd 929 5 an an DT cord-010119-t1x9gknd 929 6 urban urban JJ cord-010119-t1x9gknd 929 7 setting setting NN cord-010119-t1x9gknd 929 8 in in IN cord-010119-t1x9gknd 929 9 which which WDT cord-010119-t1x9gknd 929 10 63 63 CD cord-010119-t1x9gknd 929 11 % % NN cord-010119-t1x9gknd 929 12 of of IN cord-010119-t1x9gknd 929 13 deliveries delivery NNS cord-010119-t1x9gknd 929 14 are be VBP cord-010119-t1x9gknd 929 15 to to IN cord-010119-t1x9gknd 929 16 African african JJ cord-010119-t1x9gknd 929 17 - - HYPH cord-010119-t1x9gknd 929 18 American american JJ cord-010119-t1x9gknd 929 19 patients patient NNS cord-010119-t1x9gknd 929 20 . . . cord-010119-t1x9gknd 930 1 We -PRON- PRP cord-010119-t1x9gknd 930 2 initiated initiate VBD cord-010119-t1x9gknd 930 3 routine routine JJ cord-010119-t1x9gknd 930 4 , , , cord-010119-t1x9gknd 930 5 full full JJ cord-010119-t1x9gknd 930 6 - - HYPH cord-010119-t1x9gknd 930 7 gene gene NN cord-010119-t1x9gknd 930 8 RHDsequencing rhdsequencing NN cord-010119-t1x9gknd 930 9 for for IN cord-010119-t1x9gknd 930 10 obstetric obstetric JJ cord-010119-t1x9gknd 930 11 patients patient NNS cord-010119-t1x9gknd 930 12 whose whose WP$ cord-010119-t1x9gknd 930 13 serology serology NN cord-010119-t1x9gknd 930 14 demonstrated demonstrate VBD cord-010119-t1x9gknd 930 15 not not RB cord-010119-t1x9gknd 930 16 only only RB cord-010119-t1x9gknd 930 17 weak weak JJ cord-010119-t1x9gknd 930 18 D d NN cord-010119-t1x9gknd 930 19 , , , cord-010119-t1x9gknd 930 20 but but CC cord-010119-t1x9gknd 930 21 also also RB cord-010119-t1x9gknd 930 22 those those DT cord-010119-t1x9gknd 930 23 who who WP cord-010119-t1x9gknd 930 24 were be VBD cord-010119-t1x9gknd 930 25 categorized categorize VBN cord-010119-t1x9gknd 930 26 as as IN cord-010119-t1x9gknd 930 27 " " `` cord-010119-t1x9gknd 930 28 D1 d1 NN cord-010119-t1x9gknd 930 29 " " '' cord-010119-t1x9gknd 930 30 with with IN cord-010119-t1x9gknd 930 31 31 31 CD cord-010119-t1x9gknd 930 32 reactivity reactivity NN cord-010119-t1x9gknd 930 33 to to TO cord-010119-t1x9gknd 930 34 determine determine VB cord-010119-t1x9gknd 930 35 the the DT cord-010119-t1x9gknd 930 36 prevalence prevalence NN cord-010119-t1x9gknd 930 37 of of IN cord-010119-t1x9gknd 930 38 partial partial JJ cord-010119-t1x9gknd 930 39 D d NN cord-010119-t1x9gknd 930 40 patients patient NNS cord-010119-t1x9gknd 930 41 in in IN cord-010119-t1x9gknd 930 42 an an DT cord-010119-t1x9gknd 930 43 ethnically ethnically RB cord-010119-t1x9gknd 930 44 - - HYPH cord-010119-t1x9gknd 930 45 mixed mix VBN cord-010119-t1x9gknd 930 46 population population NN cord-010119-t1x9gknd 930 47 who who WP cord-010119-t1x9gknd 930 48 may may MD cord-010119-t1x9gknd 930 49 be be VB cord-010119-t1x9gknd 930 50 at at IN cord-010119-t1x9gknd 930 51 risk risk NN cord-010119-t1x9gknd 930 52 of of IN cord-010119-t1x9gknd 930 53 anti anti JJ cord-010119-t1x9gknd 930 54 - - JJ cord-010119-t1x9gknd 930 55 D d JJ cord-010119-t1x9gknd 930 56 formation formation NN cord-010119-t1x9gknd 930 57 . . . cord-010119-t1x9gknd 931 1 Study Study NNP cord-010119-t1x9gknd 931 2 Design Design NNP cord-010119-t1x9gknd 931 3 / / SYM cord-010119-t1x9gknd 931 4 Methods method NNS cord-010119-t1x9gknd 931 5 : : : cord-010119-t1x9gknd 932 1 From from IN cord-010119-t1x9gknd 932 2 October October NNP cord-010119-t1x9gknd 932 3 2016 2016 CD cord-010119-t1x9gknd 932 4 to to IN cord-010119-t1x9gknd 932 5 March March NNP cord-010119-t1x9gknd 932 6 2017 2017 CD cord-010119-t1x9gknd 932 7 , , , cord-010119-t1x9gknd 932 8 we -PRON- PRP cord-010119-t1x9gknd 932 9 performed perform VBD cord-010119-t1x9gknd 932 10 routine routine JJ cord-010119-t1x9gknd 932 11 D d NN cord-010119-t1x9gknd 932 12 typing typing NN cord-010119-t1x9gknd 932 13 ( ( -LRB- cord-010119-t1x9gknd 932 14 NEO NEO NNP cord-010119-t1x9gknd 932 15 , , , cord-010119-t1x9gknd 932 16 Immucor Immucor NNP cord-010119-t1x9gknd 932 17 ) ) -RRB- cord-010119-t1x9gknd 932 18 on on IN cord-010119-t1x9gknd 932 19 1875 1875 CD cord-010119-t1x9gknd 932 20 obstetric obstetric JJ cord-010119-t1x9gknd 932 21 specimens specimen NNS cord-010119-t1x9gknd 932 22 followed follow VBN cord-010119-t1x9gknd 932 23 by by IN cord-010119-t1x9gknd 932 24 RHD RHD NNP cord-010119-t1x9gknd 932 25 sequencing sequencing NN cord-010119-t1x9gknd 932 26 on on IN cord-010119-t1x9gknd 932 27 samples sample NNS cord-010119-t1x9gknd 932 28 with with IN cord-010119-t1x9gknd 932 29 either either CC cord-010119-t1x9gknd 932 30 a a DT cord-010119-t1x9gknd 932 31 serologic serologic JJ cord-010119-t1x9gknd 932 32 weak weak JJ cord-010119-t1x9gknd 932 33 D d NN cord-010119-t1x9gknd 932 34 phenotype phenotype NN cord-010119-t1x9gknd 932 35 or or CC cord-010119-t1x9gknd 932 36 anti anti JJ cord-010119-t1x9gknd 932 37 - - JJ cord-010119-t1x9gknd 932 38 D d JJ cord-010119-t1x9gknd 932 39 testing testing NN cord-010119-t1x9gknd 932 40 strength strength NN cord-010119-t1x9gknd 932 41 of of IN cord-010119-t1x9gknd 932 42 31 31 CD cord-010119-t1x9gknd 932 43 using use VBG cord-010119-t1x9gknd 932 44 at at RB cord-010119-t1x9gknd 932 45 least least JJS cord-010119-t1x9gknd 932 46 1 1 CD cord-010119-t1x9gknd 932 47 antibody antibody NN cord-010119-t1x9gknd 932 48 . . . cord-010119-t1x9gknd 933 1 Solid solid JJ cord-010119-t1x9gknd 933 2 phase phase NN cord-010119-t1x9gknd 933 3 and and CC cord-010119-t1x9gknd 933 4 manual manual JJ cord-010119-t1x9gknd 933 5 testing testing NN cord-010119-t1x9gknd 933 6 used use VBD cord-010119-t1x9gknd 933 7 the the DT cord-010119-t1x9gknd 933 8 series series NN cord-010119-t1x9gknd 933 9 4 4 CD cord-010119-t1x9gknd 933 10 and and CC cord-010119-t1x9gknd 933 11 series series NN cord-010119-t1x9gknd 933 12 5 5 CD cord-010119-t1x9gknd 933 13 reagents reagent NNS cord-010119-t1x9gknd 933 14 . . . cord-010119-t1x9gknd 934 1 Four four CD cord-010119-t1x9gknd 934 2 additional additional JJ cord-010119-t1x9gknd 934 3 anti anti JJ cord-010119-t1x9gknd 934 4 - - JJ cord-010119-t1x9gknd 934 5 D d JJ cord-010119-t1x9gknd 934 6 reagents reagent NNS cord-010119-t1x9gknd 934 7 manufactured manufacture VBN cord-010119-t1x9gknd 934 8 by by IN cord-010119-t1x9gknd 934 9 Grifols Grifols NNP cord-010119-t1x9gknd 934 10 ( ( -LRB- cord-010119-t1x9gknd 934 11 DG DG NNP cord-010119-t1x9gknd 934 12 Gel Gel NNP cord-010119-t1x9gknd 934 13 Anti Anti NNP cord-010119-t1x9gknd 934 14 - - NNP cord-010119-t1x9gknd 934 15 D d JJ cord-010119-t1x9gknd 934 16 ) ) -RRB- cord-010119-t1x9gknd 934 17 , , , cord-010119-t1x9gknd 934 18 Quotient quotient NN cord-010119-t1x9gknd 934 19 ( ( -LRB- cord-010119-t1x9gknd 934 20 Anti Anti NNP cord-010119-t1x9gknd 934 21 - - JJ cord-010119-t1x9gknd 934 22 D d JJ cord-010119-t1x9gknd 934 23 blend blend NN cord-010119-t1x9gknd 934 24 ) ) -RRB- cord-010119-t1x9gknd 934 25 , , , cord-010119-t1x9gknd 934 26 Biorad Biorad NNP cord-010119-t1x9gknd 934 27 ( ( -LRB- cord-010119-t1x9gknd 934 28 Anti Anti NNP cord-010119-t1x9gknd 934 29 - - NNP cord-010119-t1x9gknd 934 30 D d JJ cord-010119-t1x9gknd 934 31 ( ( -LRB- cord-010119-t1x9gknd 934 32 RH1 RH1 NNP cord-010119-t1x9gknd 934 33 ) ) -RRB- cord-010119-t1x9gknd 934 34 blend blend NN cord-010119-t1x9gknd 934 35 ) ) -RRB- cord-010119-t1x9gknd 934 36 , , , cord-010119-t1x9gknd 934 37 and and CC cord-010119-t1x9gknd 934 38 Ortho Ortho NNP cord-010119-t1x9gknd 934 39 ( ( -LRB- cord-010119-t1x9gknd 934 40 BioClone BioClone NNP cord-010119-t1x9gknd 934 41 Anti Anti NNP cord-010119-t1x9gknd 934 42 - - NNP cord-010119-t1x9gknd 934 43 D d JJ cord-010119-t1x9gknd 934 44 ) ) -RRB- cord-010119-t1x9gknd 934 45 were be VBD cord-010119-t1x9gknd 934 46 also also RB cord-010119-t1x9gknd 934 47 used use VBN cord-010119-t1x9gknd 934 48 for for IN cord-010119-t1x9gknd 934 49 supplemental supplemental JJ cord-010119-t1x9gknd 934 50 testing testing NN cord-010119-t1x9gknd 934 51 . . . cord-010119-t1x9gknd 935 1 RHD RHD NNP cord-010119-t1x9gknd 935 2 sequencing sequencing NN cord-010119-t1x9gknd 935 3 was be VBD cord-010119-t1x9gknd 935 4 performed perform VBN cord-010119-t1x9gknd 935 5 by by IN cord-010119-t1x9gknd 935 6 Sanger Sanger NNP cord-010119-t1x9gknd 935 7 methodology methodology NN cord-010119-t1x9gknd 935 8 using use VBG cord-010119-t1x9gknd 935 9 routine routine JJ cord-010119-t1x9gknd 935 10 clinical clinical JJ cord-010119-t1x9gknd 935 11 protocols protocol NNS cord-010119-t1x9gknd 935 12 . . . cord-010119-t1x9gknd 936 1 Results result NNS cord-010119-t1x9gknd 936 2 / / SYM cord-010119-t1x9gknd 936 3 Findings finding NNS cord-010119-t1x9gknd 936 4 : : : cord-010119-t1x9gknd 937 1 RHD RHD NNP cord-010119-t1x9gknd 937 2 polymorphisms polymorphism NNS cord-010119-t1x9gknd 937 3 or or CC cord-010119-t1x9gknd 937 4 variations variation NNS cord-010119-t1x9gknd 937 5 were be VBD cord-010119-t1x9gknd 937 6 identified identify VBN cord-010119-t1x9gknd 937 7 in in IN cord-010119-t1x9gknd 937 8 all all DT cord-010119-t1x9gknd 937 9 13 13 CD cord-010119-t1x9gknd 937 10 samples sample NNS cord-010119-t1x9gknd 937 11 . . . cord-010119-t1x9gknd 938 1 Two two CD cord-010119-t1x9gknd 938 2 of of IN cord-010119-t1x9gknd 938 3 13 13 CD cord-010119-t1x9gknd 938 4 ( ( -LRB- cord-010119-t1x9gknd 938 5 15.4 15.4 CD cord-010119-t1x9gknd 938 6 % % NN cord-010119-t1x9gknd 938 7 ) ) -RRB- cord-010119-t1x9gknd 938 8 were be VBD cord-010119-t1x9gknd 938 9 D1 d1 NN cord-010119-t1x9gknd 938 10 with with IN cord-010119-t1x9gknd 938 11 an an DT cord-010119-t1x9gknd 938 12 RHD RHD NNP cord-010119-t1x9gknd 938 13 gene gene NN cord-010119-t1x9gknd 938 14 with with IN cord-010119-t1x9gknd 938 15 only only RB cord-010119-t1x9gknd 938 16 common common JJ cord-010119-t1x9gknd 938 17 , , , cord-010119-t1x9gknd 938 18 known know VBN cord-010119-t1x9gknd 938 19 intronic intronic JJ cord-010119-t1x9gknd 938 20 variants variant NNS cord-010119-t1x9gknd 938 21 that that WDT cord-010119-t1x9gknd 938 22 is be VBZ cord-010119-t1x9gknd 938 23 predicted predict VBN cord-010119-t1x9gknd 938 24 to to TO cord-010119-t1x9gknd 938 25 produce produce VB cord-010119-t1x9gknd 938 26 the the DT cord-010119-t1x9gknd 938 27 " " `` cord-010119-t1x9gknd 938 28 reference reference NN cord-010119-t1x9gknd 938 29 " " '' cord-010119-t1x9gknd 938 30 RhD rhd NN cord-010119-t1x9gknd 938 31 protein protein NN cord-010119-t1x9gknd 938 32 ( ( -LRB- cord-010119-t1x9gknd 938 33 IVS1 IVS1 NNP cord-010119-t1x9gknd 938 34 - - HYPH cord-010119-t1x9gknd 938 35 29C 29C NNS cord-010119-t1x9gknd 938 36 , , , cord-010119-t1x9gknd 938 37 rs2301153 rs2301153 XX cord-010119-t1x9gknd 938 38 ; ; : cord-010119-t1x9gknd 938 39 IVS3 IVS3 NNP cord-010119-t1x9gknd 938 40 1 1 CD cord-010119-t1x9gknd 938 41 117C 117c CD cord-010119-t1x9gknd 938 42 , , , cord-010119-t1x9gknd 938 43 rs28521909 rs28521909 NNP cord-010119-t1x9gknd 938 44 ; ; : cord-010119-t1x9gknd 938 45 and and CC cord-010119-t1x9gknd 938 46 IVS3 IVS3 NNP cord-010119-t1x9gknd 938 47 1 1 CD cord-010119-t1x9gknd 938 48 124A 124a CD cord-010119-t1x9gknd 938 49 , , , cord-010119-t1x9gknd 938 50 rs28562109 rs28562109 NNP cord-010119-t1x9gknd 938 51 ) ) -RRB- cord-010119-t1x9gknd 938 52 . . . cord-010119-t1x9gknd 939 1 Two two CD cord-010119-t1x9gknd 939 2 ( ( -LRB- cord-010119-t1x9gknd 939 3 15.4 15.4 CD cord-010119-t1x9gknd 939 4 % % NN cord-010119-t1x9gknd 939 5 ) ) -RRB- cord-010119-t1x9gknd 939 6 were be VBD cord-010119-t1x9gknd 939 7 D1 d1 NN cord-010119-t1x9gknd 939 8 and and CC cord-010119-t1x9gknd 939 9 heterozygous heterozygous JJ cord-010119-t1x9gknd 939 10 for for IN cord-010119-t1x9gknd 939 11 two two CD cord-010119-t1x9gknd 939 12 apparently apparently RB cord-010119-t1x9gknd 939 13 new new JJ cord-010119-t1x9gknd 939 14 RHD RHD NNP cord-010119-t1x9gknd 939 15 coding coding NN cord-010119-t1x9gknd 939 16 variations variation NNS cord-010119-t1x9gknd 939 17 which which WDT cord-010119-t1x9gknd 939 18 we -PRON- PRP cord-010119-t1x9gknd 939 19 are be VBP cord-010119-t1x9gknd 939 20 confirming confirm VBG cord-010119-t1x9gknd 939 21 by by IN cord-010119-t1x9gknd 939 22 further further JJ cord-010119-t1x9gknd 939 23 testing testing NN cord-010119-t1x9gknd 939 24 . . . cord-010119-t1x9gknd 940 1 Four four CD cord-010119-t1x9gknd 940 2 ( ( -LRB- cord-010119-t1x9gknd 940 3 30.8 30.8 CD cord-010119-t1x9gknd 940 4 % % NN cord-010119-t1x9gknd 940 5 ) ) -RRB- cord-010119-t1x9gknd 940 6 patients patient NNS cord-010119-t1x9gknd 940 7 had have VBD cord-010119-t1x9gknd 940 8 RHD RHD NNP cord-010119-t1x9gknd 940 9 alleles allele NNS cord-010119-t1x9gknd 940 10 with with IN cord-010119-t1x9gknd 940 11 known know VBN cord-010119-t1x9gknd 940 12 potential potential NN cord-010119-t1x9gknd 940 13 to to TO cord-010119-t1x9gknd 940 14 make make VB cord-010119-t1x9gknd 940 15 anti anti JJ cord-010119-t1x9gknd 940 16 - - JJ cord-010119-t1x9gknd 940 17 D d JJ cord-010119-t1x9gknd 940 18 ( ( -LRB- cord-010119-t1x9gknd 940 19 RHD*DOL2 rhd*dol2 XX cord-010119-t1x9gknd 940 20 , , , cord-010119-t1x9gknd 940 21 RHD*DAR1.2 RHD*DAR1.2 NNP cord-010119-t1x9gknd 940 22 , , , cord-010119-t1x9gknd 940 23 and and CC cord-010119-t1x9gknd 940 24 2 2 CD cord-010119-t1x9gknd 940 25 with with IN cord-010119-t1x9gknd 940 26 weak weak JJ cord-010119-t1x9gknd 940 27 D d NN cord-010119-t1x9gknd 940 28 type type NN cord-010119-t1x9gknd 940 29 4.0 4.0 CD cord-010119-t1x9gknd 940 30 ) ) -RRB- cord-010119-t1x9gknd 940 31 . . . cord-010119-t1x9gknd 941 1 One one PRP cord-010119-t1x9gknd 941 2 had have VBD cord-010119-t1x9gknd 941 3 weak weak JJ cord-010119-t1x9gknd 941 4 D d NN cord-010119-t1x9gknd 941 5 type type NN cord-010119-t1x9gknd 941 6 96 96 CD cord-010119-t1x9gknd 941 7 , , , cord-010119-t1x9gknd 941 8 which which WDT cord-010119-t1x9gknd 941 9 has have VBZ cord-010119-t1x9gknd 941 10 uncertain uncertain JJ cord-010119-t1x9gknd 941 11 susceptibility susceptibility NN cord-010119-t1x9gknd 941 12 to to IN cord-010119-t1x9gknd 941 13 alloimmunization alloimmunization NN cord-010119-t1x9gknd 941 14 and and CC cord-010119-t1x9gknd 941 15 one one CD cord-010119-t1x9gknd 941 16 was be VBD cord-010119-t1x9gknd 941 17 weak weak JJ cord-010119-t1x9gknd 941 18 D d NN cord-010119-t1x9gknd 941 19 type type NN cord-010119-t1x9gknd 941 20 1 1 CD cord-010119-t1x9gknd 941 21 , , , cord-010119-t1x9gknd 941 22 which which WDT cord-010119-t1x9gknd 941 23 has have VBZ cord-010119-t1x9gknd 941 24 not not RB cord-010119-t1x9gknd 941 25 yet yet RB cord-010119-t1x9gknd 941 26 been be VBN cord-010119-t1x9gknd 941 27 associated associate VBN cord-010119-t1x9gknd 941 28 with with IN cord-010119-t1x9gknd 941 29 anti anti JJ cord-010119-t1x9gknd 941 30 - - NNP cord-010119-t1x9gknd 941 31 D. D. NNP cord-010119-t1x9gknd 941 32 Interestingly interestingly RB cord-010119-t1x9gknd 941 33 , , , cord-010119-t1x9gknd 941 34 two two CD cord-010119-t1x9gknd 941 35 ( ( -LRB- cord-010119-t1x9gknd 941 36 15.4 15.4 CD cord-010119-t1x9gknd 941 37 % % NN cord-010119-t1x9gknd 941 38 ) ) -RRB- cord-010119-t1x9gknd 941 39 had have VBD cord-010119-t1x9gknd 941 40 variable variable JJ cord-010119-t1x9gknd 941 41 D d NN cord-010119-t1x9gknd 941 42 expression expression NN cord-010119-t1x9gknd 941 43 associated associate VBN cord-010119-t1x9gknd 941 44 with with IN cord-010119-t1x9gknd 941 45 apparently apparently RB cord-010119-t1x9gknd 941 46 new new JJ cord-010119-t1x9gknd 941 47 alleles allele NNS cord-010119-t1x9gknd 941 48 , , , cord-010119-t1x9gknd 941 49 pending pende VBG cord-010119-t1x9gknd 941 50 ongoing ongoing JJ cord-010119-t1x9gknd 941 51 confirmatory confirmatory JJ cord-010119-t1x9gknd 941 52 testing testing NN cord-010119-t1x9gknd 941 53 and and CC cord-010119-t1x9gknd 941 54 cloning cloning NN cord-010119-t1x9gknd 941 55 . . . cord-010119-t1x9gknd 942 1 One one CD cord-010119-t1x9gknd 942 2 patient patient NN cord-010119-t1x9gknd 942 3 Background Background NNP cord-010119-t1x9gknd 942 4 / / SYM cord-010119-t1x9gknd 942 5 Case Case NNP cord-010119-t1x9gknd 942 6 Studies Studies NNPS cord-010119-t1x9gknd 942 7 : : : cord-010119-t1x9gknd 943 1 A a DT cord-010119-t1x9gknd 943 2 weak weak JJ cord-010119-t1x9gknd 943 3 D d NN cord-010119-t1x9gknd 943 4 type type NN cord-010119-t1x9gknd 943 5 2 2 CD cord-010119-t1x9gknd 943 6 is be VBZ cord-010119-t1x9gknd 943 7 a a DT cord-010119-t1x9gknd 943 8 variant variant NN cord-010119-t1x9gknd 943 9 of of IN cord-010119-t1x9gknd 943 10 the the DT cord-010119-t1x9gknd 943 11 RhD RhD NNP cord-010119-t1x9gknd 943 12 protein protein NN cord-010119-t1x9gknd 943 13 that that WDT cord-010119-t1x9gknd 943 14 comprises comprise VBZ cord-010119-t1x9gknd 943 15 an an DT cord-010119-t1x9gknd 943 16 amino amino NN cord-010119-t1x9gknd 943 17 acid acid NN cord-010119-t1x9gknd 943 18 substitution substitution NN cord-010119-t1x9gknd 943 19 located locate VBN cord-010119-t1x9gknd 943 20 in in IN cord-010119-t1x9gknd 943 21 the the DT cord-010119-t1x9gknd 943 22 12th 12th JJ cord-010119-t1x9gknd 943 23 transmembrane transmembrane NN cord-010119-t1x9gknd 943 24 segment segment NN cord-010119-t1x9gknd 943 25 and and CC cord-010119-t1x9gknd 943 26 expresses express VBZ cord-010119-t1x9gknd 943 27 a a DT cord-010119-t1x9gknd 943 28 reduced reduce VBN cord-010119-t1x9gknd 943 29 amount amount NN cord-010119-t1x9gknd 943 30 of of IN cord-010119-t1x9gknd 943 31 the the DT cord-010119-t1x9gknd 943 32 D d NN cord-010119-t1x9gknd 943 33 antigen antigen NN cord-010119-t1x9gknd 943 34 . . . cord-010119-t1x9gknd 944 1 This this DT cord-010119-t1x9gknd 944 2 variant variant NN cord-010119-t1x9gknd 944 3 is be VBZ cord-010119-t1x9gknd 944 4 known know VBN cord-010119-t1x9gknd 944 5 to to TO cord-010119-t1x9gknd 944 6 be be VB cord-010119-t1x9gknd 944 7 associated associate VBN cord-010119-t1x9gknd 944 8 with with IN cord-010119-t1x9gknd 944 9 the the DT cord-010119-t1x9gknd 944 10 missense missense NN cord-010119-t1x9gknd 944 11 mutation mutation NN cord-010119-t1x9gknd 944 12 c.1154 c.1154 NNS cord-010119-t1x9gknd 944 13 G g NN cord-010119-t1x9gknd 944 14 > > XX cord-010119-t1x9gknd 944 15 C c NN cord-010119-t1x9gknd 944 16 which which WDT cord-010119-t1x9gknd 944 17 is be VBZ cord-010119-t1x9gknd 944 18 the the DT cord-010119-t1x9gknd 944 19 first first JJ cord-010119-t1x9gknd 944 20 nucleotide nucleotide NN cord-010119-t1x9gknd 944 21 of of IN cord-010119-t1x9gknd 944 22 the the DT cord-010119-t1x9gknd 944 23 exon exon NN cord-010119-t1x9gknd 944 24 9 9 CD cord-010119-t1x9gknd 944 25 of of IN cord-010119-t1x9gknd 944 26 the the DT cord-010119-t1x9gknd 944 27 RHD RHD NNP cord-010119-t1x9gknd 944 28 gene gene NN cord-010119-t1x9gknd 944 29 and and CC cord-010119-t1x9gknd 944 30 thus thus RB cord-010119-t1x9gknd 944 31 could could MD cord-010119-t1x9gknd 944 32 be be VB cord-010119-t1x9gknd 944 33 implicated implicate VBN cord-010119-t1x9gknd 944 34 in in IN cord-010119-t1x9gknd 944 35 exon exon NN cord-010119-t1x9gknd 944 36 9 9 CD cord-010119-t1x9gknd 944 37 skipping skipping NN cord-010119-t1x9gknd 944 38 when when WRB cord-010119-t1x9gknd 944 39 it -PRON- PRP cord-010119-t1x9gknd 944 40 is be VBZ cord-010119-t1x9gknd 944 41 mutated mutate VBN cord-010119-t1x9gknd 944 42 . . . cord-010119-t1x9gknd 945 1 When when WRB cord-010119-t1x9gknd 945 2 performing perform VBG cord-010119-t1x9gknd 945 3 NGS NGS NNP cord-010119-t1x9gknd 945 4 ( ( -LRB- cord-010119-t1x9gknd 945 5 Next Next NNP cord-010119-t1x9gknd 945 6 Generation Generation NNP cord-010119-t1x9gknd 945 7 Sequencing Sequencing NNP cord-010119-t1x9gknd 945 8 ) ) -RRB- cord-010119-t1x9gknd 945 9 analysis analysis NN cord-010119-t1x9gknd 945 10 to to TO cord-010119-t1x9gknd 945 11 fully fully RB cord-010119-t1x9gknd 945 12 genotype genotype VB cord-010119-t1x9gknd 945 13 known know VBN cord-010119-t1x9gknd 945 14 patients patient NNS cord-010119-t1x9gknd 945 15 , , , cord-010119-t1x9gknd 945 16 we -PRON- PRP cord-010119-t1x9gknd 945 17 identified identify VBD cord-010119-t1x9gknd 945 18 an an DT cord-010119-t1x9gknd 945 19 additional additional JJ cord-010119-t1x9gknd 945 20 variant variant NN cord-010119-t1x9gknd 945 21 . . . cord-010119-t1x9gknd 946 1 Study Study NNP cord-010119-t1x9gknd 946 2 Design Design NNP cord-010119-t1x9gknd 946 3 / / SYM cord-010119-t1x9gknd 946 4 Method method NN cord-010119-t1x9gknd 946 5 : : : cord-010119-t1x9gknd 947 1 DNA dna NN cord-010119-t1x9gknd 947 2 samples sample NNS cord-010119-t1x9gknd 947 3 were be VBD cord-010119-t1x9gknd 947 4 studied study VBN cord-010119-t1x9gknd 947 5 by by IN cord-010119-t1x9gknd 947 6 Beadchip Beadchip NNP cord-010119-t1x9gknd 947 7 technology technology NN cord-010119-t1x9gknd 947 8 ( ( -LRB- cord-010119-t1x9gknd 947 9 Immucor Immucor NNP cord-010119-t1x9gknd 947 10 / / SYM cord-010119-t1x9gknd 947 11 Bioarray Bioarray NNP cord-010119-t1x9gknd 947 12 solutions solution NNS cord-010119-t1x9gknd 947 13 ) ) -RRB- cord-010119-t1x9gknd 947 14 and and CC cord-010119-t1x9gknd 947 15 NGS NGS NNP cord-010119-t1x9gknd 947 16 using use VBG cord-010119-t1x9gknd 947 17 the the DT cord-010119-t1x9gknd 947 18 SureSelect SureSelect NNP cord-010119-t1x9gknd 947 19 Human Human NNP cord-010119-t1x9gknd 947 20 All all DT cord-010119-t1x9gknd 947 21 Exon Exon NNP cord-010119-t1x9gknd 947 22 V6 V6 NNP cord-010119-t1x9gknd 947 23 ( ( -LRB- cord-010119-t1x9gknd 947 24 Agilent Agilent NNP cord-010119-t1x9gknd 947 25 ) ) -RRB- cord-010119-t1x9gknd 947 26 and and CC cord-010119-t1x9gknd 947 27 the the DT cord-010119-t1x9gknd 947 28 Nextseq500 Nextseq500 NNP cord-010119-t1x9gknd 947 29 platform platform NN cord-010119-t1x9gknd 947 30 . . . cord-010119-t1x9gknd 948 1 In in IN cord-010119-t1x9gknd 948 2 silico silico NN cord-010119-t1x9gknd 948 3 analysis analysis NN cord-010119-t1x9gknd 948 4 with with IN cord-010119-t1x9gknd 948 5 different different JJ cord-010119-t1x9gknd 948 6 bioinformatic bioinformatic JJ cord-010119-t1x9gknd 948 7 tools tool NNS cord-010119-t1x9gknd 948 8 was be VBD cord-010119-t1x9gknd 948 9 used use VBN cord-010119-t1x9gknd 948 10 to to TO cord-010119-t1x9gknd 948 11 predict predict VB cord-010119-t1x9gknd 948 12 splicing splicing NN cord-010119-t1x9gknd 948 13 events event NNS cord-010119-t1x9gknd 948 14 . . . cord-010119-t1x9gknd 949 1 Furthermore furthermore RB cord-010119-t1x9gknd 949 2 , , , cord-010119-t1x9gknd 949 3 a a DT cord-010119-t1x9gknd 949 4 functional functional JJ cord-010119-t1x9gknd 949 5 splicing splicing NN cord-010119-t1x9gknd 949 6 assay assay NN cord-010119-t1x9gknd 949 7 was be VBD cord-010119-t1x9gknd 949 8 performed perform VBN cord-010119-t1x9gknd 949 9 to to TO cord-010119-t1x9gknd 949 10 determine determine VB cord-010119-t1x9gknd 949 11 the the DT cord-010119-t1x9gknd 949 12 impact impact NN cord-010119-t1x9gknd 949 13 of of IN cord-010119-t1x9gknd 949 14 the the DT cord-010119-t1x9gknd 949 15 nucleotide nucleotide JJ cord-010119-t1x9gknd 949 16 variations variation NNS cord-010119-t1x9gknd 949 17 on on IN cord-010119-t1x9gknd 949 18 exon exon NN cord-010119-t1x9gknd 949 19 9 9 CD cord-010119-t1x9gknd 949 20 skipping skipping NN cord-010119-t1x9gknd 949 21 of of IN cord-010119-t1x9gknd 949 22 RHD RHD NNP cord-010119-t1x9gknd 949 23 gene gene NN cord-010119-t1x9gknd 949 24 . . . cord-010119-t1x9gknd 950 1 This this DT cord-010119-t1x9gknd 950 2 study study NN cord-010119-t1x9gknd 950 3 was be VBD cord-010119-t1x9gknd 950 4 completed complete VBN cord-010119-t1x9gknd 950 5 by by IN cord-010119-t1x9gknd 950 6 the the DT cord-010119-t1x9gknd 950 7 comparative comparative JJ cord-010119-t1x9gknd 950 8 modeling modeling NN cord-010119-t1x9gknd 950 9 between between IN cord-010119-t1x9gknd 950 10 the the DT cord-010119-t1x9gknd 950 11 wild wild JJ cord-010119-t1x9gknd 950 12 type type NN cord-010119-t1x9gknd 950 13 and and CC cord-010119-t1x9gknd 950 14 the the DT cord-010119-t1x9gknd 950 15 weak weak JJ cord-010119-t1x9gknd 950 16 type type NN cord-010119-t1x9gknd 950 17 2 2 CD cord-010119-t1x9gknd 950 18 RhD rhd NN cord-010119-t1x9gknd 950 19 proteins protein NNS cord-010119-t1x9gknd 950 20 . . . cord-010119-t1x9gknd 951 1 Results/ Results/ . cord-010119-t1x9gknd 952 1 Finding find VBG cord-010119-t1x9gknd 953 1 : : : cord-010119-t1x9gknd 953 2 By by IN cord-010119-t1x9gknd 953 3 a a DT cord-010119-t1x9gknd 953 4 targeted target VBN cord-010119-t1x9gknd 953 5 analysis analysis NN cord-010119-t1x9gknd 953 6 of of IN cord-010119-t1x9gknd 953 7 full full JJ cord-010119-t1x9gknd 953 8 exome exome NN cord-010119-t1x9gknd 953 9 sequencing sequencing NN cord-010119-t1x9gknd 953 10 , , , cord-010119-t1x9gknd 953 11 we -PRON- PRP cord-010119-t1x9gknd 953 12 have have VBP cord-010119-t1x9gknd 953 13 confirmed confirm VBN cord-010119-t1x9gknd 953 14 the the DT cord-010119-t1x9gknd 953 15 blood blood NN cord-010119-t1x9gknd 953 16 group group NN cord-010119-t1x9gknd 953 17 genotype genotype NN cord-010119-t1x9gknd 953 18 of of IN cord-010119-t1x9gknd 953 19 10 10 CD cord-010119-t1x9gknd 953 20 patients patient NNS cord-010119-t1x9gknd 953 21 previously previously RB cord-010119-t1x9gknd 953 22 characterized characterize VBN cord-010119-t1x9gknd 953 23 by by IN cord-010119-t1x9gknd 953 24 BeadChip BeadChip NNP cord-010119-t1x9gknd 953 25 technology technology NN cord-010119-t1x9gknd 953 26 . . . cord-010119-t1x9gknd 954 1 Interestingly interestingly RB cord-010119-t1x9gknd 954 2 , , , cord-010119-t1x9gknd 954 3 4 4 CD cord-010119-t1x9gknd 954 4 out out IN cord-010119-t1x9gknd 954 5 of of IN cord-010119-t1x9gknd 954 6 10 10 CD cord-010119-t1x9gknd 954 7 carry carry VBP cord-010119-t1x9gknd 954 8 the the DT cord-010119-t1x9gknd 954 9 c.1154 c.1154 NNPS cord-010119-t1x9gknd 954 10 - - HYPH cord-010119-t1x9gknd 954 11 31C 31c ADD cord-010119-t1x9gknd 955 1 > > XX cord-010119-t1x9gknd 956 1 T T NNP cord-010119-t1x9gknd 956 2 intronic intronic JJ cord-010119-t1x9gknd 956 3 variation variation NN cord-010119-t1x9gknd 956 4 on on IN cord-010119-t1x9gknd 956 5 the the DT cord-010119-t1x9gknd 956 6 RHD RHD NNP cord-010119-t1x9gknd 956 7 gene gene NN cord-010119-t1x9gknd 956 8 , , , cord-010119-t1x9gknd 956 9 already already RB cord-010119-t1x9gknd 956 10 described describe VBN cord-010119-t1x9gknd 956 11 and and CC cord-010119-t1x9gknd 956 12 associated associate VBN cord-010119-t1x9gknd 956 13 with with IN cord-010119-t1x9gknd 956 14 a a DT cord-010119-t1x9gknd 956 15 Del Del NNP cord-010119-t1x9gknd 956 16 allele allele NN cord-010119-t1x9gknd 956 17 . . . cord-010119-t1x9gknd 957 1 Among among IN cord-010119-t1x9gknd 957 2 these these DT cord-010119-t1x9gknd 957 3 last last JJ cord-010119-t1x9gknd 957 4 4 4 CD cord-010119-t1x9gknd 957 5 patients patient NNS cord-010119-t1x9gknd 957 6 , , , cord-010119-t1x9gknd 957 7 one one PRP cord-010119-t1x9gknd 957 8 has have VBZ cord-010119-t1x9gknd 957 9 been be VBN cord-010119-t1x9gknd 957 10 previously previously RB cord-010119-t1x9gknd 957 11 characterized characterize VBN cord-010119-t1x9gknd 957 12 as as IN cord-010119-t1x9gknd 957 13 RHD RHD NNP cord-010119-t1x9gknd 957 14 weak weak JJ cord-010119-t1x9gknd 957 15 type type NN cord-010119-t1x9gknd 957 16 2 2 CD cord-010119-t1x9gknd 957 17 carrying carry VBG cord-010119-t1x9gknd 957 18 the the DT cord-010119-t1x9gknd 957 19 c.1154G c.1154g NN cord-010119-t1x9gknd 957 20 > > XX cord-010119-t1x9gknd 957 21 C c NN cord-010119-t1x9gknd 957 22 ( ( -LRB- cord-010119-t1x9gknd 957 23 p p NN cord-010119-t1x9gknd 957 24 . . . cord-010119-t1x9gknd 957 25 Gly385Ala Gly385Ala NNS cord-010119-t1x9gknd 957 26 ) ) -RRB- cord-010119-t1x9gknd 957 27 . . . cord-010119-t1x9gknd 958 1 Independently independently RB cord-010119-t1x9gknd 958 2 , , , cord-010119-t1x9gknd 958 3 Sanger Sanger NNP cord-010119-t1x9gknd 958 4 sequencing sequencing NN cord-010119-t1x9gknd 958 5 on on IN cord-010119-t1x9gknd 958 6 50 50 CD cord-010119-t1x9gknd 958 7 unrelated unrelated JJ cord-010119-t1x9gknd 958 8 RHD RHD NNP cord-010119-t1x9gknd 958 9 weak weak JJ cord-010119-t1x9gknd 958 10 type type NN cord-010119-t1x9gknd 958 11 2 2 CD cord-010119-t1x9gknd 958 12 samples sample NNS cord-010119-t1x9gknd 958 13 pinpoint pinpoint VBP cord-010119-t1x9gknd 958 14 to to IN cord-010119-t1x9gknd 958 15 a a DT cord-010119-t1x9gknd 958 16 linkage linkage NN cord-010119-t1x9gknd 958 17 disequilibrium disequilibrium NN cord-010119-t1x9gknd 958 18 between between IN cord-010119-t1x9gknd 958 19 c.1154 c.1154 NNS cord-010119-t1x9gknd 958 20 G g NN cord-010119-t1x9gknd 958 21 > > XX cord-010119-t1x9gknd 959 1 C C NNP cord-010119-t1x9gknd 960 1 ( ( -LRB- cord-010119-t1x9gknd 960 2 ExAC ExAC NNP cord-010119-t1x9gknd 960 3 , , , cord-010119-t1x9gknd 960 4 MAF MAF NNP cord-010119-t1x9gknd 960 5 5 5 CD cord-010119-t1x9gknd 960 6 0.001145 0.001145 CD cord-010119-t1x9gknd 960 7 ) ) -RRB- cord-010119-t1x9gknd 960 8 and and CC cord-010119-t1x9gknd 960 9 the the DT cord-010119-t1x9gknd 960 10 c.1154 c.1154 NNP cord-010119-t1x9gknd 960 11 - - HYPH cord-010119-t1x9gknd 960 12 31C 31C -RRB- cord-010119-t1x9gknd 961 1 > > XX cord-010119-t1x9gknd 962 1 T T NNP cord-010119-t1x9gknd 962 2 ( ( -LRB- cord-010119-t1x9gknd 962 3 ExAC ExAC NNP cord-010119-t1x9gknd 962 4 , , , cord-010119-t1x9gknd 962 5 MAF MAF NNP cord-010119-t1x9gknd 962 6 5 5 CD cord-010119-t1x9gknd 962 7 0.2496 0.2496 CD cord-010119-t1x9gknd 962 8 ) ) -RRB- cord-010119-t1x9gknd 962 9 . . . cord-010119-t1x9gknd 963 1 In in IN cord-010119-t1x9gknd 963 2 silico silico NN cord-010119-t1x9gknd 963 3 analysis analysis NN cord-010119-t1x9gknd 963 4 of of IN cord-010119-t1x9gknd 963 5 both both DT cord-010119-t1x9gknd 963 6 mutation mutation NN cord-010119-t1x9gknd 963 7 located locate VBN cord-010119-t1x9gknd 963 8 close close RB cord-010119-t1x9gknd 963 9 to to IN cord-010119-t1x9gknd 963 10 the the DT cord-010119-t1x9gknd 963 11 splice splice NN cord-010119-t1x9gknd 963 12 acceptor acceptor NN cord-010119-t1x9gknd 963 13 site site NN cord-010119-t1x9gknd 963 14 of of IN cord-010119-t1x9gknd 963 15 the the DT cord-010119-t1x9gknd 963 16 exon exon NN cord-010119-t1x9gknd 963 17 9 9 CD cord-010119-t1x9gknd 963 18 does do VBZ cord-010119-t1x9gknd 963 19 not not RB cord-010119-t1x9gknd 963 20 predict predict VB cord-010119-t1x9gknd 963 21 a a DT cord-010119-t1x9gknd 963 22 significant significant JJ cord-010119-t1x9gknd 963 23 reduction reduction NN cord-010119-t1x9gknd 963 24 of of IN cord-010119-t1x9gknd 963 25 its -PRON- PRP$ cord-010119-t1x9gknd 963 26 strength strength NN cord-010119-t1x9gknd 963 27 score score NN cord-010119-t1x9gknd 963 28 . . . cord-010119-t1x9gknd 964 1 With with IN cord-010119-t1x9gknd 964 2 minigene minigene NN cord-010119-t1x9gknd 964 3 vectors vector NNS cord-010119-t1x9gknd 964 4 harboring harbor VBG cord-010119-t1x9gknd 964 5 RHD RHD NNP cord-010119-t1x9gknd 964 6 wildtype wildtype NN cord-010119-t1x9gknd 964 7 exon exon NN cord-010119-t1x9gknd 964 8 9 9 CD cord-010119-t1x9gknd 964 9 , , , cord-010119-t1x9gknd 964 10 mutant mutant JJ cord-010119-t1x9gknd 964 11 RHD RHD NNP cord-010119-t1x9gknd 964 12 c.1154 c.1154 NNS cord-010119-t1x9gknd 964 13 G g NN cord-010119-t1x9gknd 965 1 > > XX cord-010119-t1x9gknd 966 1 C C NNP cord-010119-t1x9gknd 966 2 , , , cord-010119-t1x9gknd 966 3 mutant mutant JJ cord-010119-t1x9gknd 967 1 RHD RHD NNP cord-010119-t1x9gknd 967 2 c.1154- c.1154- NNP cord-010119-t1x9gknd 968 1 31C 31c LS cord-010119-t1x9gknd 969 1 > > XX cord-010119-t1x9gknd 970 1 T T NNP cord-010119-t1x9gknd 970 2 and and CC cord-010119-t1x9gknd 970 3 double double JJ cord-010119-t1x9gknd 970 4 RHD RHD NNP cord-010119-t1x9gknd 970 5 mutants mutant NNS cord-010119-t1x9gknd 971 1 c.1154 c.1154 NNP cord-010119-t1x9gknd 971 2 G G NNP cord-010119-t1x9gknd 972 1 > > XX cord-010119-t1x9gknd 973 1 C C NNP cord-010119-t1x9gknd 973 2 plus plus CC cord-010119-t1x9gknd 973 3 c.1154 c.1154 NNPS cord-010119-t1x9gknd 974 1 -31C -31c RB cord-010119-t1x9gknd 974 2 > > XX cord-010119-t1x9gknd 975 1 T T NNP cord-010119-t1x9gknd 975 2 , , , cord-010119-t1x9gknd 975 3 we -PRON- PRP cord-010119-t1x9gknd 975 4 showed show VBD cord-010119-t1x9gknd 975 5 no no DT cord-010119-t1x9gknd 975 6 influence influence NN cord-010119-t1x9gknd 975 7 on on IN cord-010119-t1x9gknd 975 8 skipping skipping NN cord-010119-t1x9gknd 975 9 of of IN cord-010119-t1x9gknd 975 10 exon exon NN cord-010119-t1x9gknd 975 11 9 9 CD cord-010119-t1x9gknd 975 12 due due IN cord-010119-t1x9gknd 975 13 to to IN cord-010119-t1x9gknd 975 14 these these DT cord-010119-t1x9gknd 975 15 mutations mutation NNS cord-010119-t1x9gknd 975 16 . . . cord-010119-t1x9gknd 976 1 Comparative comparative JJ cord-010119-t1x9gknd 976 2 modeling modeling NN cord-010119-t1x9gknd 976 3 of of IN cord-010119-t1x9gknd 976 4 RhD rhd NN cord-010119-t1x9gknd 976 5 proteins protein NNS cord-010119-t1x9gknd 976 6 pointed point VBD cord-010119-t1x9gknd 976 7 out out RP cord-010119-t1x9gknd 976 8 an an DT cord-010119-t1x9gknd 976 9 additional additional JJ cord-010119-t1x9gknd 976 10 hydrophobic hydrophobic JJ cord-010119-t1x9gknd 976 11 interaction interaction NN cord-010119-t1x9gknd 976 12 on on IN cord-010119-t1x9gknd 976 13 the the DT cord-010119-t1x9gknd 976 14 RhD RhD NNP cord-010119-t1x9gknd 976 15 weak weak JJ cord-010119-t1x9gknd 976 16 type type NN cord-010119-t1x9gknd 976 17 2 2 CD cord-010119-t1x9gknd 976 18 between between IN cord-010119-t1x9gknd 976 19 Ala385 ala385 CD cord-010119-t1x9gknd 976 20 ( ( -LRB- cord-010119-t1x9gknd 976 21 transmembrane transmembrane NNP cord-010119-t1x9gknd 976 22 helix helix NNP cord-010119-t1x9gknd 976 23 12 12 CD cord-010119-t1x9gknd 976 24 ) ) -RRB- cord-010119-t1x9gknd 976 25 and and CC cord-010119-t1x9gknd 976 26 Val183 val183 LS cord-010119-t1x9gknd 976 27 ( ( -LRB- cord-010119-t1x9gknd 976 28 transmembrane transmembrane NNP cord-010119-t1x9gknd 976 29 helix helix NNP cord-010119-t1x9gknd 976 30 6 6 CD cord-010119-t1x9gknd 976 31 ) ) -RRB- cord-010119-t1x9gknd 976 32 hampering hamper VBG cord-010119-t1x9gknd 976 33 membrane membrane NN cord-010119-t1x9gknd 976 34 insertion insertion NN cord-010119-t1x9gknd 976 35 . . . cord-010119-t1x9gknd 977 1 Conclusion conclusion NN cord-010119-t1x9gknd 977 2 : : : cord-010119-t1x9gknd 978 1 The the DT cord-010119-t1x9gknd 978 2 c.1154 c.1154 NNP cord-010119-t1x9gknd 978 3 - - HYPH cord-010119-t1x9gknd 978 4 31C 31C NNS cord-010119-t1x9gknd 978 5 > > XX cord-010119-t1x9gknd 979 1 T T NNP cord-010119-t1x9gknd 979 2 variation variation NN cord-010119-t1x9gknd 979 3 is be VBZ cord-010119-t1x9gknd 979 4 always always RB cord-010119-t1x9gknd 979 5 associated associate VBN cord-010119-t1x9gknd 979 6 in in IN cord-010119-t1x9gknd 979 7 cis cis NNP cord-010119-t1x9gknd 979 8 with with IN cord-010119-t1x9gknd 979 9 the the DT cord-010119-t1x9gknd 979 10 missense missense NN cord-010119-t1x9gknd 979 11 mutation mutation NN cord-010119-t1x9gknd 979 12 c.1154 c.1154 NNS cord-010119-t1x9gknd 979 13 G g NN cord-010119-t1x9gknd 980 1 > > XX cord-010119-t1x9gknd 981 1 C C NNP cord-010119-t1x9gknd 981 2 on on IN cord-010119-t1x9gknd 981 3 the the DT cord-010119-t1x9gknd 981 4 allele allele NN cord-010119-t1x9gknd 981 5 RHD RHD NNP cord-010119-t1x9gknd 981 6 weak weak JJ cord-010119-t1x9gknd 981 7 type type NN cord-010119-t1x9gknd 981 8 2 2 CD cord-010119-t1x9gknd 981 9 . . . cord-010119-t1x9gknd 982 1 The the DT cord-010119-t1x9gknd 982 2 c.1154 c.1154 NNP cord-010119-t1x9gknd 982 3 - - HYPH cord-010119-t1x9gknd 982 4 31C 31C NNS cord-010119-t1x9gknd 982 5 > > XX cord-010119-t1x9gknd 983 1 T T NNP cord-010119-t1x9gknd 983 2 can can MD cord-010119-t1x9gknd 983 3 be be VB cord-010119-t1x9gknd 983 4 found find VBN cord-010119-t1x9gknd 983 5 alone alone JJ cord-010119-t1x9gknd 983 6 on on IN cord-010119-t1x9gknd 983 7 the the DT cord-010119-t1x9gknd 983 8 RHD RHD NNP cord-010119-t1x9gknd 983 9 gene gene NN cord-010119-t1x9gknd 983 10 as as IN cord-010119-t1x9gknd 983 11 a a DT cord-010119-t1x9gknd 983 12 neutral neutral JJ cord-010119-t1x9gknd 983 13 polymorphism polymorphism NN cord-010119-t1x9gknd 983 14 . . . cord-010119-t1x9gknd 984 1 We -PRON- PRP cord-010119-t1x9gknd 984 2 assess assess VBP cord-010119-t1x9gknd 984 3 that that IN cord-010119-t1x9gknd 984 4 these these DT cord-010119-t1x9gknd 984 5 two two CD cord-010119-t1x9gknd 984 6 mutations mutation NNS cord-010119-t1x9gknd 984 7 isolated isolate VBN cord-010119-t1x9gknd 984 8 or or CC cord-010119-t1x9gknd 984 9 combined combine VBN cord-010119-t1x9gknd 984 10 do do VBP cord-010119-t1x9gknd 984 11 not not RB cord-010119-t1x9gknd 984 12 lead lead VB cord-010119-t1x9gknd 984 13 to to IN cord-010119-t1x9gknd 984 14 abnormal abnormal JJ cord-010119-t1x9gknd 984 15 RHD RHD NNP cord-010119-t1x9gknd 984 16 transcripts transcript NNS cord-010119-t1x9gknd 984 17 . . . cord-010119-t1x9gknd 985 1 Our -PRON- PRP$ cord-010119-t1x9gknd 985 2 results result NNS cord-010119-t1x9gknd 985 3 clearly clearly RB cord-010119-t1x9gknd 985 4 demonstrate demonstrate VBP cord-010119-t1x9gknd 985 5 that that IN cord-010119-t1x9gknd 985 6 the the DT cord-010119-t1x9gknd 985 7 weak weak JJ cord-010119-t1x9gknd 985 8 D D NNP cord-010119-t1x9gknd 985 9 antigen antigen NN cord-010119-t1x9gknd 985 10 reactivity reactivity NN cord-010119-t1x9gknd 985 11 observed observe VBN cord-010119-t1x9gknd 985 12 with with IN cord-010119-t1x9gknd 985 13 RhD RhD NNP cord-010119-t1x9gknd 985 14 type type NNP cord-010119-t1x9gknd 985 15 2 2 CD cord-010119-t1x9gknd 985 16 red red JJ cord-010119-t1x9gknd 985 17 blood blood NN cord-010119-t1x9gknd 985 18 cells cell NNS cord-010119-t1x9gknd 985 19 is be VBZ cord-010119-t1x9gknd 985 20 due due JJ cord-010119-t1x9gknd 985 21 to to IN cord-010119-t1x9gknd 985 22 the the DT cord-010119-t1x9gknd 985 23 substitution substitution NN cord-010119-t1x9gknd 985 24 of of IN cord-010119-t1x9gknd 985 25 alanine alanine NN cord-010119-t1x9gknd 985 26 at at IN cord-010119-t1x9gknd 985 27 amino amino NN cord-010119-t1x9gknd 985 28 acid acid NN cord-010119-t1x9gknd 985 29 position position NN cord-010119-t1x9gknd 985 30 385 385 CD cord-010119-t1x9gknd 985 31 to to IN cord-010119-t1x9gknd 985 32 glycine glycine NN cord-010119-t1x9gknd 985 33 . . . cord-010119-t1x9gknd 986 1 Topology topology NN cord-010119-t1x9gknd 986 2 of of IN cord-010119-t1x9gknd 986 3 Jk Jk NNP cord-010119-t1x9gknd 987 1 -Weak -Weak NNP cord-010119-t1x9gknd 987 2 or or CC cord-010119-t1x9gknd 987 3 Jk Jk NNP cord-010119-t1x9gknd 987 4 - - HYPH cord-010119-t1x9gknd 987 5 Negative negative JJ cord-010119-t1x9gknd 987 6 Single Single NNP cord-010119-t1x9gknd 987 7 - - HYPH cord-010119-t1x9gknd 987 8 Nucleotide nucleotide JJ cord-010119-t1x9gknd 987 9 Missense Missense NNP cord-010119-t1x9gknd 987 10 Variants Variants NNPS cord-010119-t1x9gknd 987 11 in in IN cord-010119-t1x9gknd 987 12 the the DT cord-010119-t1x9gknd 987 13 Kidd Kidd NNP cord-010119-t1x9gknd 987 14 Protein Protein NNP cord-010119-t1x9gknd 987 15 Glenn Glenn NNP cord-010119-t1x9gknd 987 16 Ramsey Ramsey NNP cord-010119-t1x9gknd 988 1 * * NFP cord-010119-t1x9gknd 988 2 . . . cord-010119-t1x9gknd 989 1 Northwestern Northwestern NNP cord-010119-t1x9gknd 989 2 University University NNP cord-010119-t1x9gknd 989 3 Background Background NNP cord-010119-t1x9gknd 989 4 / / SYM cord-010119-t1x9gknd 989 5 Case Case NNP cord-010119-t1x9gknd 989 6 Studies Studies NNPS cord-010119-t1x9gknd 989 7 : : : cord-010119-t1x9gknd 990 1 The the DT cord-010119-t1x9gknd 990 2 human human JJ cord-010119-t1x9gknd 990 3 urea urea NN cord-010119-t1x9gknd 990 4 transporter transporter NN cord-010119-t1x9gknd 990 5 - - HYPH cord-010119-t1x9gknd 990 6 B b NN cord-010119-t1x9gknd 990 7 ( ( -LRB- cord-010119-t1x9gknd 990 8 HUT hut NN cord-010119-t1x9gknd 990 9 - - HYPH cord-010119-t1x9gknd 990 10 B B NNP cord-010119-t1x9gknd 990 11 ) ) -RRB- cord-010119-t1x9gknd 990 12 protein protein NN cord-010119-t1x9gknd 990 13 carrying carry VBG cord-010119-t1x9gknd 990 14 the the DT cord-010119-t1x9gknd 990 15 Kidd Kidd NNP cord-010119-t1x9gknd 990 16 blood blood NN cord-010119-t1x9gknd 990 17 group group NN cord-010119-t1x9gknd 990 18 has have VBZ cord-010119-t1x9gknd 990 19 10 10 CD cord-010119-t1x9gknd 990 20 transmembrane transmembrane NN cord-010119-t1x9gknd 990 21 ( ( -LRB- cord-010119-t1x9gknd 990 22 TM TM NNP cord-010119-t1x9gknd 990 23 ) ) -RRB- cord-010119-t1x9gknd 990 24 and and CC cord-010119-t1x9gknd 990 25 2 2 CD cord-010119-t1x9gknd 990 26 tilted tilt VBN cord-010119-t1x9gknd 990 27 ureapore ureapore NNP cord-010119-t1x9gknd 990 28 a a DT cord-010119-t1x9gknd 990 29 - - : cord-010119-t1x9gknd 990 30 helices helix NNS cord-010119-t1x9gknd 990 31 , , , cord-010119-t1x9gknd 990 32 a a DT cord-010119-t1x9gknd 990 33 long long JJ cord-010119-t1x9gknd 990 34 extracellular extracellular JJ cord-010119-t1x9gknd 990 35 connector connector NN cord-010119-t1x9gknd 990 36 segment segment NN cord-010119-t1x9gknd 990 37 , , , cord-010119-t1x9gknd 990 38 and and CC cord-010119-t1x9gknd 990 39 2 2 CD cord-010119-t1x9gknd 990 40 cytoplasmic cytoplasmic JJ cord-010119-t1x9gknd 990 41 segments segment NNS cord-010119-t1x9gknd 990 42 at at IN cord-010119-t1x9gknd 990 43 each each DT cord-010119-t1x9gknd 990 44 end end NN cord-010119-t1x9gknd 990 45 . . . cord-010119-t1x9gknd 991 1 Numerous numerous JJ cord-010119-t1x9gknd 991 2 single single JJ cord-010119-t1x9gknd 991 3 - - HYPH cord-010119-t1x9gknd 991 4 nucleotide nucleotide NN cord-010119-t1x9gknd 991 5 missense missense NN cord-010119-t1x9gknd 991 6 variants variant NNS cord-010119-t1x9gknd 991 7 ( ( -LRB- cord-010119-t1x9gknd 991 8 SNMVs snmv NNS cord-010119-t1x9gknd 991 9 ) ) -RRB- cord-010119-t1x9gknd 991 10 weaken weaken VB cord-010119-t1x9gknd 991 11 or or CC cord-010119-t1x9gknd 991 12 abolish abolish VB cord-010119-t1x9gknd 991 13 expression expression NN cord-010119-t1x9gknd 991 14 of of IN cord-010119-t1x9gknd 991 15 Jk Jk NNP cord-010119-t1x9gknd 991 16 a a NNP cord-010119-t1x9gknd 991 17 / / SYM cord-010119-t1x9gknd 991 18 b b NN cord-010119-t1x9gknd 991 19 antigens antigen NNS cord-010119-t1x9gknd 991 20 determined determine VBN cord-010119-t1x9gknd 991 21 at at IN cord-010119-t1x9gknd 991 22 p.280 p.280 NNP cord-010119-t1x9gknd 991 23 . . . cord-010119-t1x9gknd 992 1 We -PRON- PRP cord-010119-t1x9gknd 992 2 mapped map VBD cord-010119-t1x9gknd 992 3 all all DT cord-010119-t1x9gknd 992 4 reported report VBN cord-010119-t1x9gknd 992 5 Jk Jk NNP cord-010119-t1x9gknd 992 6 - - HYPH cord-010119-t1x9gknd 992 7 weak weak JJ cord-010119-t1x9gknd 992 8 or or CC cord-010119-t1x9gknd 992 9 Jk Jk NNP cord-010119-t1x9gknd 992 10 - - HYPH cord-010119-t1x9gknd 992 11 negative negative JJ cord-010119-t1x9gknd 993 1 ( ( -LRB- cord-010119-t1x9gknd 993 2 Jk Jk NNP cord-010119-t1x9gknd 993 3 - - HYPH cord-010119-t1x9gknd 993 4 neg neg NNP cord-010119-t1x9gknd 993 5 ) ) -RRB- cord-010119-t1x9gknd 993 6 SNMVs snmv NNS cord-010119-t1x9gknd 993 7 onto onto IN cord-010119-t1x9gknd 993 8 the the DT cord-010119-t1x9gknd 993 9 HUT HUT NNP cord-010119-t1x9gknd 993 10 - - HYPH cord-010119-t1x9gknd 993 11 B b NN cord-010119-t1x9gknd 993 12 structure structure NN cord-010119-t1x9gknd 993 13 to to TO cord-010119-t1x9gknd 993 14 explore explore VB cord-010119-t1x9gknd 993 15 topological topological JJ cord-010119-t1x9gknd 993 16 correlates correlate NNS cord-010119-t1x9gknd 993 17 of of IN cord-010119-t1x9gknd 993 18 Jk Jk NNP cord-010119-t1x9gknd 993 19 antigen antigen NN cord-010119-t1x9gknd 993 20 expression expression NN cord-010119-t1x9gknd 993 21 . . . cord-010119-t1x9gknd 994 1 Study Study NNP cord-010119-t1x9gknd 994 2 Design Design NNP cord-010119-t1x9gknd 994 3 / / SYM cord-010119-t1x9gknd 994 4 Methods method NNS cord-010119-t1x9gknd 994 5 : : : cord-010119-t1x9gknd 995 1 JK*A JK*A NNP cord-010119-t1x9gknd 995 2 and and CC cord-010119-t1x9gknd 995 3 JK*B JK*B NNP cord-010119-t1x9gknd 995 4 SNMVs snmv NNS cord-010119-t1x9gknd 995 5 affecting affect VBG cord-010119-t1x9gknd 995 6 Jk Jk NNP cord-010119-t1x9gknd 995 7 expression expression NN cord-010119-t1x9gknd 995 8 were be VBD cord-010119-t1x9gknd 995 9 compiled compile VBN cord-010119-t1x9gknd 995 10 from from IN cord-010119-t1x9gknd 995 11 dbRBC dbrbc RB cord-010119-t1x9gknd 995 12 and and CC cord-010119-t1x9gknd 995 13 ISBT ISBT NNP cord-010119-t1x9gknd 995 14 registries registry NNS cord-010119-t1x9gknd 995 15 , , , cord-010119-t1x9gknd 995 16 literature literature NN cord-010119-t1x9gknd 995 17 searches search NNS cord-010119-t1x9gknd 995 18 and and CC cord-010119-t1x9gknd 995 19 2010 2010 CD cord-010119-t1x9gknd 995 20 - - SYM cord-010119-t1x9gknd 995 21 2016 2016 CD cord-010119-t1x9gknd 995 22 AABB AABB NNP cord-010119-t1x9gknd 995 23 , , , cord-010119-t1x9gknd 995 24 ISBT ISBT NNP cord-010119-t1x9gknd 995 25 and and CC cord-010119-t1x9gknd 995 26 British British NNP cord-010119-t1x9gknd 995 27 Blood Blood NNP cord-010119-t1x9gknd 995 28 Transfusion Transfusion NNP cord-010119-t1x9gknd 995 29 Society Society NNP cord-010119-t1x9gknd 996 1 meeting meeting NN cord-010119-t1x9gknd 996 2 abstracts abstract NNS cord-010119-t1x9gknd 996 3 . . . cord-010119-t1x9gknd 997 1 SNMV SNMV NNP cord-010119-t1x9gknd 997 2 locations location NNS cord-010119-t1x9gknd 997 3 were be VBD cord-010119-t1x9gknd 997 4 correlated correlate VBN cord-010119-t1x9gknd 997 5 with with IN cord-010119-t1x9gknd 997 6 the the DT cord-010119-t1x9gknd 997 7 human human JJ cord-010119-t1x9gknd 997 8 homolog homolog NN cord-010119-t1x9gknd 997 9 of of IN cord-010119-t1x9gknd 997 10 the the DT cord-010119-t1x9gknd 997 11 x x NN cord-010119-t1x9gknd 997 12 - - NN cord-010119-t1x9gknd 997 13 ray ray NN cord-010119-t1x9gknd 997 14 - - HYPH cord-010119-t1x9gknd 997 15 crystallographic crystallographic JJ cord-010119-t1x9gknd 997 16 structure structure NN cord-010119-t1x9gknd 997 17 of of IN cord-010119-t1x9gknd 997 18 mammalian mammalian JJ cord-010119-t1x9gknd 997 19 UT UT NNP cord-010119-t1x9gknd 997 20 - - HYPH cord-010119-t1x9gknd 997 21 B B NNP cord-010119-t1x9gknd 997 22 derived derive VBN cord-010119-t1x9gknd 997 23 for for IN cord-010119-t1x9gknd 997 24 analysis analysis NN cord-010119-t1x9gknd 997 25 of of IN cord-010119-t1x9gknd 997 26 UT UT NNP cord-010119-t1x9gknd 997 27 function function NN cord-010119-t1x9gknd 997 28 ( ( -LRB- cord-010119-t1x9gknd 997 29 Levin Levin NNP cord-010119-t1x9gknd 997 30 EJ EJ NNP cord-010119-t1x9gknd 997 31 , , , cord-010119-t1x9gknd 997 32 2012 2012 CD cord-010119-t1x9gknd 997 33 ) ) -RRB- cord-010119-t1x9gknd 997 34 . . . cord-010119-t1x9gknd 998 1 Results/ Results/ . cord-010119-t1x9gknd 999 1 Finding finding NN cord-010119-t1x9gknd 999 2 : : : cord-010119-t1x9gknd 1000 1 Seven seven CD cord-010119-t1x9gknd 1000 2 SNMVs snmv NNS cord-010119-t1x9gknd 1000 3 located locate VBN cord-010119-t1x9gknd 1000 4 within within IN cord-010119-t1x9gknd 1000 5 1 1 CD cord-010119-t1x9gknd 1000 6 amino amino NN cord-010119-t1x9gknd 1000 7 acid acid NN cord-010119-t1x9gknd 1000 8 ( ( -LRB- cord-010119-t1x9gknd 1000 9 aa aa NNP cord-010119-t1x9gknd 1000 10 ) ) -RRB- cord-010119-t1x9gknd 1000 11 from from IN cord-010119-t1x9gknd 1000 12 the the DT cord-010119-t1x9gknd 1000 13 exofacial exofacial JJ cord-010119-t1x9gknd 1000 14 or or CC cord-010119-t1x9gknd 1000 15 internal internal JJ cord-010119-t1x9gknd 1000 16 end end NN cord-010119-t1x9gknd 1000 17 of of IN cord-010119-t1x9gknd 1000 18 a a DT cord-010119-t1x9gknd 1000 19 TM TM NNP cord-010119-t1x9gknd 1000 20 helix helix NN cord-010119-t1x9gknd 1000 21 are be VBP cord-010119-t1x9gknd 1000 22 mostly mostly RB cord-010119-t1x9gknd 1000 23 weak weak JJ cord-010119-t1x9gknd 1000 24 variants variant NNS cord-010119-t1x9gknd 1000 25 ( ( -LRB- cord-010119-t1x9gknd 1000 26 Table table NN cord-010119-t1x9gknd 1000 27 ) ) -RRB- cord-010119-t1x9gknd 1000 28 . . . cord-010119-t1x9gknd 1001 1 All all DT cord-010119-t1x9gknd 1001 2 3 3 CD cord-010119-t1x9gknd 1001 3 at at IN cord-010119-t1x9gknd 1001 4 the the DT cord-010119-t1x9gknd 1001 5 exofacial exofacial NN cord-010119-t1x9gknd 1001 6 ends end NNS cord-010119-t1x9gknd 1001 7 ( ( -LRB- cord-010119-t1x9gknd 1001 8 p p NN cord-010119-t1x9gknd 1001 9 . . . cord-010119-t1x9gknd 1001 10 A93 A93 NNP cord-010119-t1x9gknd 1001 11 T T NNP cord-010119-t1x9gknd 1001 12 , , , cord-010119-t1x9gknd 1001 13 p. p. NN cord-010119-t1x9gknd 1002 1 W240R W240R NNP cord-010119-t1x9gknd 1002 2 , , , cord-010119-t1x9gknd 1002 3 p. p. NN cord-010119-t1x9gknd 1003 1 V333D v333d NN cord-010119-t1x9gknd 1003 2 ) ) -RRB- cord-010119-t1x9gknd 1003 3 are be VBP cord-010119-t1x9gknd 1003 4 Jk Jk NNP cord-010119-t1x9gknd 1003 5 - - HYPH cord-010119-t1x9gknd 1003 6 weak weak JJ cord-010119-t1x9gknd 1003 7 ; ; : cord-010119-t1x9gknd 1003 8 the the DT cord-010119-t1x9gknd 1003 9 two two CD cord-010119-t1x9gknd 1003 10 Jkneg Jkneg NNP cord-010119-t1x9gknd 1003 11 exceptions exception NNS cord-010119-t1x9gknd 1003 12 p. p. NN cord-010119-t1x9gknd 1004 1 G298E G298E NNP cord-010119-t1x9gknd 1004 2 and and CC cord-010119-t1x9gknd 1004 3 p. p. NN cord-010119-t1x9gknd 1005 1 G299E G299E NNS cord-010119-t1x9gknd 1005 2 are be VBP cord-010119-t1x9gknd 1005 3 at at IN cord-010119-t1x9gknd 1005 4 the the DT cord-010119-t1x9gknd 1005 5 internal internal JJ cord-010119-t1x9gknd 1005 6 end end NN cord-010119-t1x9gknd 1005 7 of of IN cord-010119-t1x9gknd 1005 8 the the DT cord-010119-t1x9gknd 1005 9 TM TM NNP cord-010119-t1x9gknd 1005 10 helix helix NN cord-010119-t1x9gknd 1005 11 bearing bearing NN cord-010119-t1x9gknd 1006 1 Jk Jk NNP cord-010119-t1x9gknd 1007 1 a a LS cord-010119-t1x9gknd 1007 2 / / SYM cord-010119-t1x9gknd 1007 3 b b NN cord-010119-t1x9gknd 1007 4 . . . cord-010119-t1x9gknd 1008 1 Four four CD cord-010119-t1x9gknd 1008 2 SNMVs snmv NNS cord-010119-t1x9gknd 1008 3 in in IN cord-010119-t1x9gknd 1008 4 the the DT cord-010119-t1x9gknd 1008 5 cytoplasmic cytoplasmic JJ cord-010119-t1x9gknd 1008 6 N n CD cord-010119-t1x9gknd 1008 7 - - HYPH cord-010119-t1x9gknd 1008 8 terminal terminal NN cord-010119-t1x9gknd 1008 9 segment segment NN cord-010119-t1x9gknd 1008 10 are be VBP cord-010119-t1x9gknd 1008 11 mostly mostly RB cord-010119-t1x9gknd 1008 12 weak weak JJ cord-010119-t1x9gknd 1008 13 variants variant NNS cord-010119-t1x9gknd 1008 14 . . . cord-010119-t1x9gknd 1009 1 In in IN cord-010119-t1x9gknd 1009 2 contrast contrast NN cord-010119-t1x9gknd 1009 3 , , , cord-010119-t1x9gknd 1009 4 13 13 CD cord-010119-t1x9gknd 1009 5 SNMVs snmv NNS cord-010119-t1x9gknd 1009 6 within within IN cord-010119-t1x9gknd 1009 7 membrane membrane NN cord-010119-t1x9gknd 1009 8 helices helix NNS cord-010119-t1x9gknd 1009 9 are be VBP cord-010119-t1x9gknd 1009 10 mostly mostly RB cord-010119-t1x9gknd 1009 11 Jk Jk NNP cord-010119-t1x9gknd 1009 12 - - HYPH cord-010119-t1x9gknd 1009 13 neg neg JJ cord-010119-t1x9gknd 1009 14 variants variant NNS cord-010119-t1x9gknd 1009 15 . . . cord-010119-t1x9gknd 1010 1 Three three CD cord-010119-t1x9gknd 1010 2 Jk Jk NNP cord-010119-t1x9gknd 1010 3 - - HYPH cord-010119-t1x9gknd 1010 4 weak weak JJ cord-010119-t1x9gknd 1010 5 SNMVs snmv NNS cord-010119-t1x9gknd 1010 6 ( ( -LRB- cord-010119-t1x9gknd 1010 7 p. p. NN cord-010119-t1x9gknd 1011 1 V10 V10 NNP cord-010119-t1x9gknd 1011 2 M M NNP cord-010119-t1x9gknd 1011 3 , , , cord-010119-t1x9gknd 1011 4 p p NN cord-010119-t1x9gknd 1011 5 . . . cord-010119-t1x9gknd 1011 6 E44 E44 NNP cord-010119-t1x9gknd 1011 7 K K NNP cord-010119-t1x9gknd 1011 8 , , , cord-010119-t1x9gknd 1011 9 p p NN cord-010119-t1x9gknd 1011 10 . . . cord-010119-t1x9gknd 1011 11 V76I V76I NNP cord-010119-t1x9gknd 1011 12 ) ) -RRB- cord-010119-t1x9gknd 1011 13 have have VBP cord-010119-t1x9gknd 1011 14 been be VBN cord-010119-t1x9gknd 1011 15 associated associate VBN cord-010119-t1x9gknd 1011 16 with with IN cord-010119-t1x9gknd 1011 17 allo allo NN cord-010119-t1x9gknd 1011 18 - - HYPH cord-010119-t1x9gknd 1011 19 anti anti NN cord-010119-t1x9gknd 1011 20 - - NN cord-010119-t1x9gknd 1011 21 Jk Jk NNP cord-010119-t1x9gknd 1012 1 a a LS cord-010119-t1x9gknd 1012 2 / / SYM cord-010119-t1x9gknd 1012 3 b b NN cord-010119-t1x9gknd 1012 4 to to IN cord-010119-t1x9gknd 1012 5 the the DT cord-010119-t1x9gknd 1012 6 antigen antigen NN cord-010119-t1x9gknd 1012 7 on on IN cord-010119-t1x9gknd 1012 8 their -PRON- PRP$ cord-010119-t1x9gknd 1012 9 alleles allele NNS cord-010119-t1x9gknd 1012 10 ( ( -LRB- cord-010119-t1x9gknd 1012 11 " " `` cord-010119-t1x9gknd 1012 12 weak weak JJ cord-010119-t1x9gknd 1012 13 partial partial JJ cord-010119-t1x9gknd 1012 14 " " '' cord-010119-t1x9gknd 1012 15 ) ) -RRB- cord-010119-t1x9gknd 1012 16 . . . cord-010119-t1x9gknd 1013 1 Six six CD cord-010119-t1x9gknd 1013 2 of of IN cord-010119-t1x9gknd 1013 3 the the DT cord-010119-t1x9gknd 1013 4 13 13 CD cord-010119-t1x9gknd 1013 5 Jk Jk NNP cord-010119-t1x9gknd 1013 6 - - HYPH cord-010119-t1x9gknd 1013 7 neg neg JJ cord-010119-t1x9gknd 1013 8 variants variant NNS cord-010119-t1x9gknd 1013 9 are be VBP cord-010119-t1x9gknd 1013 10 within within IN cord-010119-t1x9gknd 1013 11 19 19 CD cord-010119-t1x9gknd 1013 12 aa aa NNP cord-010119-t1x9gknd 1013 13 ( ( -LRB- cord-010119-t1x9gknd 1013 14 p.270-p.299 p.270-p.299 NNP cord-010119-t1x9gknd 1013 15 ) ) -RRB- cord-010119-t1x9gknd 1013 16 of of IN cord-010119-t1x9gknd 1013 17 Jk Jk NNP cord-010119-t1x9gknd 1014 1 a a LS cord-010119-t1x9gknd 1014 2 / / SYM cord-010119-t1x9gknd 1014 3 b b NN cord-010119-t1x9gknd 1014 4 at at IN cord-010119-t1x9gknd 1014 5 p.280 p.280 NNP cord-010119-t1x9gknd 1014 6 . . . cord-010119-t1x9gknd 1015 1 None none NN cord-010119-t1x9gknd 1015 2 of of IN cord-010119-t1x9gknd 1015 3 these these DT cord-010119-t1x9gknd 1015 4 SNMVs snmv NNS cord-010119-t1x9gknd 1015 5 are be VBP cord-010119-t1x9gknd 1015 6 in in IN cord-010119-t1x9gknd 1015 7 the the DT cord-010119-t1x9gknd 1015 8 long long JJ cord-010119-t1x9gknd 1015 9 extracellular extracellular JJ cord-010119-t1x9gknd 1015 10 connector connector NN cord-010119-t1x9gknd 1015 11 region region NN cord-010119-t1x9gknd 1015 12 or or CC cord-010119-t1x9gknd 1015 13 the the DT cord-010119-t1x9gknd 1015 14 cytoplasmic cytoplasmic JJ cord-010119-t1x9gknd 1015 15 C c NN cord-010119-t1x9gknd 1015 16 - - HYPH cord-010119-t1x9gknd 1015 17 terminal terminal NN cord-010119-t1x9gknd 1015 18 segment segment NN cord-010119-t1x9gknd 1015 19 . . . cord-010119-t1x9gknd 1016 1 Jk Jk NNP cord-010119-t1x9gknd 1016 2 - - HYPH cord-010119-t1x9gknd 1016 3 neg neg JJ cord-010119-t1x9gknd 1016 4 variants variant NNS cord-010119-t1x9gknd 1016 5 p. p. NN cord-010119-t1x9gknd 1017 1 N289S N289S NNP cord-010119-t1x9gknd 1017 2 and and CC cord-010119-t1x9gknd 1017 3 p. p. NN cord-010119-t1x9gknd 1018 1 S291P S291P NNP cord-010119-t1x9gknd 1018 2 are be VBP cord-010119-t1x9gknd 1018 3 adjacent adjacent JJ cord-010119-t1x9gknd 1018 4 to to IN cord-010119-t1x9gknd 1018 5 p.288F p.288F NNP cord-010119-t1x9gknd 1018 6 and and CC cord-010119-t1x9gknd 1018 7 p.292L p.292L NNP cord-010119-t1x9gknd 1019 1 which which WDT cord-010119-t1x9gknd 1019 2 line line NN cord-010119-t1x9gknd 1019 3 part part NN cord-010119-t1x9gknd 1019 4 of of IN cord-010119-t1x9gknd 1019 5 the the DT cord-010119-t1x9gknd 1019 6 urea urea NN cord-010119-t1x9gknd 1019 7 transporter transporter NN cord-010119-t1x9gknd 1019 8 pore pore NN cord-010119-t1x9gknd 1019 9 . . . cord-010119-t1x9gknd 1020 1 Conclusion conclusion NN cord-010119-t1x9gknd 1020 2 : : : cord-010119-t1x9gknd 1021 1 In in IN cord-010119-t1x9gknd 1021 2 the the DT cord-010119-t1x9gknd 1021 3 transporter transporter NN cord-010119-t1x9gknd 1021 4 - - HYPH cord-010119-t1x9gknd 1021 5 structured structure VBN cord-010119-t1x9gknd 1021 6 RhD rhd NN cord-010119-t1x9gknd 1021 7 and and CC cord-010119-t1x9gknd 1021 8 RhCE rhce NN cord-010119-t1x9gknd 1021 9 proteins protein NNS cord-010119-t1x9gknd 1021 10 , , , cord-010119-t1x9gknd 1021 11 SNMVs snmv NNS cord-010119-t1x9gknd 1021 12 with with IN cord-010119-t1x9gknd 1021 13 weak weak JJ cord-010119-t1x9gknd 1021 14 D d NN cord-010119-t1x9gknd 1021 15 , , , cord-010119-t1x9gknd 1021 16 C C NNP cord-010119-t1x9gknd 1021 17 , , , cord-010119-t1x9gknd 1021 18 c c NNP cord-010119-t1x9gknd 1021 19 , , , cord-010119-t1x9gknd 1021 20 E e NN cord-010119-t1x9gknd 1021 21 or or CC cord-010119-t1x9gknd 1021 22 e e LS cord-010119-t1x9gknd 1021 23 expression expression NN cord-010119-t1x9gknd 1021 24 are be VBP cord-010119-t1x9gknd 1021 25 mostly mostly RB cord-010119-t1x9gknd 1021 26 within within IN cord-010119-t1x9gknd 1021 27 the the DT cord-010119-t1x9gknd 1021 28 RBC RBC NNP cord-010119-t1x9gknd 1021 29 membrane membrane NN cord-010119-t1x9gknd 1021 30 , , , cord-010119-t1x9gknd 1021 31 and and CC cord-010119-t1x9gknd 1021 32 non non JJ cord-010119-t1x9gknd 1021 33 - - JJ cord-010119-t1x9gknd 1021 34 canonical canonical JJ cord-010119-t1x9gknd 1021 35 antigen antigen NN cord-010119-t1x9gknd 1021 36 - - HYPH cord-010119-t1x9gknd 1021 37 negative negative JJ cord-010119-t1x9gknd 1021 38 SNMVs snmv NNS cord-010119-t1x9gknd 1021 39 are be VBP cord-010119-t1x9gknd 1021 40 unusual unusual JJ cord-010119-t1x9gknd 1021 41 . . . cord-010119-t1x9gknd 1022 1 In in IN cord-010119-t1x9gknd 1022 2 the the DT cord-010119-t1x9gknd 1022 3 structurally structurally RB cord-010119-t1x9gknd 1022 4 similar similar JJ cord-010119-t1x9gknd 1022 5 Kidd Kidd NNP cord-010119-t1x9gknd 1022 6 HUT HUT NNP cord-010119-t1x9gknd 1022 7 - - HYPH cord-010119-t1x9gknd 1022 8 B B NNP cord-010119-t1x9gknd 1022 9 , , , cord-010119-t1x9gknd 1022 10 most most JJS cord-010119-t1x9gknd 1022 11 Jk Jk NNP cord-010119-t1x9gknd 1022 12 - - HYPH cord-010119-t1x9gknd 1022 13 weak weak JJ cord-010119-t1x9gknd 1022 14 SNMVs snmv NNS cord-010119-t1x9gknd 1022 15 are be VBP cord-010119-t1x9gknd 1022 16 at at IN cord-010119-t1x9gknd 1022 17 the the DT cord-010119-t1x9gknd 1022 18 ends end NNS cord-010119-t1x9gknd 1022 19 of of IN cord-010119-t1x9gknd 1022 20 the the DT cord-010119-t1x9gknd 1022 21 TM TM NNP cord-010119-t1x9gknd 1022 22 helices helix NNS cord-010119-t1x9gknd 1022 23 or or CC cord-010119-t1x9gknd 1022 24 in in IN cord-010119-t1x9gknd 1022 25 the the DT cord-010119-t1x9gknd 1022 26 N n CD cord-010119-t1x9gknd 1022 27 - - HYPH cord-010119-t1x9gknd 1022 28 terminal terminal JJ cord-010119-t1x9gknd 1022 29 cytoplasmic cytoplasmic JJ cord-010119-t1x9gknd 1022 30 segment segment NN cord-010119-t1x9gknd 1022 31 . . . cord-010119-t1x9gknd 1023 1 Among among IN cord-010119-t1x9gknd 1023 2 13 13 CD cord-010119-t1x9gknd 1023 3 Jk Jk NNP cord-010119-t1x9gknd 1023 4 - - HYPH cord-010119-t1x9gknd 1023 5 neg neg NN cord-010119-t1x9gknd 1023 6 SNMVs snmv NNS cord-010119-t1x9gknd 1023 7 , , , cord-010119-t1x9gknd 1023 8 most most JJS cord-010119-t1x9gknd 1023 9 are be VBP cord-010119-t1x9gknd 1023 10 in in IN cord-010119-t1x9gknd 1023 11 membrane membrane NN cord-010119-t1x9gknd 1023 12 helices helix NNS cord-010119-t1x9gknd 1023 13 . . . cord-010119-t1x9gknd 1024 1 However however RB cord-010119-t1x9gknd 1024 2 , , , cord-010119-t1x9gknd 1024 3 whether whether IN cord-010119-t1x9gknd 1024 4 a a DT cord-010119-t1x9gknd 1024 5 variant variant NN cord-010119-t1x9gknd 1024 6 appears appear VBZ cord-010119-t1x9gknd 1024 7 Jk Jk NNP cord-010119-t1x9gknd 1024 8 - - HYPH cord-010119-t1x9gknd 1024 9 weak weak JJ cord-010119-t1x9gknd 1024 10 or or CC cord-010119-t1x9gknd 1025 1 Jk Jk NNP cord-010119-t1x9gknd 1025 2 - - HYPH cord-010119-t1x9gknd 1025 3 neg neg NNP cord-010119-t1x9gknd 1025 4 may may MD cord-010119-t1x9gknd 1025 5 depend depend VB cord-010119-t1x9gknd 1025 6 on on IN cord-010119-t1x9gknd 1025 7 the the DT cord-010119-t1x9gknd 1025 8 extent extent NN cord-010119-t1x9gknd 1025 9 of of IN cord-010119-t1x9gknd 1025 10 testing testing NN cord-010119-t1x9gknd 1025 11 . . . cord-010119-t1x9gknd 1026 1 Next next JJ cord-010119-t1x9gknd 1026 2 - - HYPH cord-010119-t1x9gknd 1026 3 generation generation NN cord-010119-t1x9gknd 1026 4 sequencing sequencing NN cord-010119-t1x9gknd 1026 5 may may MD cord-010119-t1x9gknd 1026 6 provide provide VB cord-010119-t1x9gknd 1026 7 more more RBR cord-010119-t1x9gknd 1026 8 complete complete JJ cord-010119-t1x9gknd 1026 9 structure structure NN cord-010119-t1x9gknd 1026 10 - - HYPH cord-010119-t1x9gknd 1026 11 antigen antigen NN cord-010119-t1x9gknd 1026 12 correlations correlation NNS cord-010119-t1x9gknd 1026 13 . . . cord-010119-t1x9gknd 1027 1 Background Background NNP cord-010119-t1x9gknd 1027 2 / / SYM cord-010119-t1x9gknd 1027 3 Case Case NNP cord-010119-t1x9gknd 1027 4 Studies Studies NNPS cord-010119-t1x9gknd 1027 5 : : : cord-010119-t1x9gknd 1028 1 The the DT cord-010119-t1x9gknd 1028 2 Kidd Kidd NNP cord-010119-t1x9gknd 1028 3 - - HYPH cord-010119-t1x9gknd 1028 4 null null JJ cord-010119-t1x9gknd 1028 5 blood blood NN cord-010119-t1x9gknd 1028 6 group group NN cord-010119-t1x9gknd 1028 7 is be VBZ cord-010119-t1x9gknd 1028 8 most most RBS cord-010119-t1x9gknd 1028 9 often often RB cord-010119-t1x9gknd 1028 10 inherited inherit VBN cord-010119-t1x9gknd 1028 11 as as IN cord-010119-t1x9gknd 1028 12 a a DT cord-010119-t1x9gknd 1028 13 recessive recessive JJ cord-010119-t1x9gknd 1028 14 genetic genetic JJ cord-010119-t1x9gknd 1028 15 trait trait NN cord-010119-t1x9gknd 1028 16 due due IN cord-010119-t1x9gknd 1028 17 to to IN cord-010119-t1x9gknd 1028 18 biallelic biallelic NN cord-010119-t1x9gknd 1028 19 mutations mutation NNS cord-010119-t1x9gknd 1028 20 in in IN cord-010119-t1x9gknd 1028 21 the the DT cord-010119-t1x9gknd 1028 22 SLC14A1 SLC14A1 NNP cord-010119-t1x9gknd 1028 23 gene gene NN cord-010119-t1x9gknd 1028 24 , , , cord-010119-t1x9gknd 1028 25 which which WDT cord-010119-t1x9gknd 1028 26 encodes encode VBZ cord-010119-t1x9gknd 1028 27 the the DT cord-010119-t1x9gknd 1028 28 urea urea NN cord-010119-t1x9gknd 1028 29 transporter transporter NN cord-010119-t1x9gknd 1028 30 UT ut NN cord-010119-t1x9gknd 1028 31 - - HYPH cord-010119-t1x9gknd 1028 32 B1 b1 NN cord-010119-t1x9gknd 1028 33 . . . cord-010119-t1x9gknd 1029 1 The the DT cord-010119-t1x9gknd 1029 2 Kidd Kidd NNP cord-010119-t1x9gknd 1029 3 - - HYPH cord-010119-t1x9gknd 1029 4 null null JJ cord-010119-t1x9gknd 1029 5 phenotype phenotype NN cord-010119-t1x9gknd 1029 6 is be VBZ cord-010119-t1x9gknd 1029 7 associated associate VBN cord-010119-t1x9gknd 1029 8 with with IN cord-010119-t1x9gknd 1029 9 transfusion transfusion NN cord-010119-t1x9gknd 1029 10 risk risk NN cord-010119-t1x9gknd 1029 11 and and CC cord-010119-t1x9gknd 1029 12 also also RB cord-010119-t1x9gknd 1029 13 is be VBZ cord-010119-t1x9gknd 1029 14 associated associate VBN cord-010119-t1x9gknd 1029 15 with with IN cord-010119-t1x9gknd 1029 16 abnormalities abnormality NNS cord-010119-t1x9gknd 1029 17 in in IN cord-010119-t1x9gknd 1029 18 the the DT cord-010119-t1x9gknd 1029 19 ability ability NN cord-010119-t1x9gknd 1029 20 to to TO cord-010119-t1x9gknd 1029 21 concentrate concentrate VB cord-010119-t1x9gknd 1029 22 urine urine NN cord-010119-t1x9gknd 1029 23 . . . cord-010119-t1x9gknd 1030 1 The the DT cord-010119-t1x9gknd 1030 2 cause cause NN cord-010119-t1x9gknd 1030 3 of of IN cord-010119-t1x9gknd 1030 4 the the DT cord-010119-t1x9gknd 1030 5 identical identical JJ cord-010119-t1x9gknd 1030 6 Kidd Kidd NNP cord-010119-t1x9gknd 1030 7 - - HYPH cord-010119-t1x9gknd 1030 8 null null JJ cord-010119-t1x9gknd 1030 9 phenotype phenotype NN cord-010119-t1x9gknd 1030 10 with with IN cord-010119-t1x9gknd 1030 11 dominant dominant JJ cord-010119-t1x9gknd 1030 12 inheritance inheritance NN cord-010119-t1x9gknd 1031 1 [ [ -LRB- cord-010119-t1x9gknd 1031 2 In(Jk in(jk LS cord-010119-t1x9gknd 1031 3 ) ) -RRB- cord-010119-t1x9gknd 1031 4 ] ] -RRB- cord-010119-t1x9gknd 1031 5 has have VBZ cord-010119-t1x9gknd 1031 6 not not RB cord-010119-t1x9gknd 1031 7 yet yet RB cord-010119-t1x9gknd 1031 8 been be VBN cord-010119-t1x9gknd 1031 9 defined define VBN cord-010119-t1x9gknd 1031 10 , , , cord-010119-t1x9gknd 1031 11 though though IN cord-010119-t1x9gknd 1031 12 it -PRON- PRP cord-010119-t1x9gknd 1031 13 was be VBD cord-010119-t1x9gknd 1031 14 first first RB cord-010119-t1x9gknd 1031 15 described describe VBN cord-010119-t1x9gknd 1031 16 in in IN cord-010119-t1x9gknd 1031 17 1965 1965 CD cord-010119-t1x9gknd 1031 18 . . . cord-010119-t1x9gknd 1032 1 In in IN cord-010119-t1x9gknd 1032 2 contrast contrast NN cord-010119-t1x9gknd 1032 3 to to IN cord-010119-t1x9gknd 1032 4 recessively recessively RB cord-010119-t1x9gknd 1032 5 inherited inherit VBN cord-010119-t1x9gknd 1032 6 Kidd Kidd NNP cord-010119-t1x9gknd 1032 7 - - HYPH cord-010119-t1x9gknd 1032 8 null null JJ cord-010119-t1x9gknd 1032 9 phenotype phenotype NN cord-010119-t1x9gknd 1032 10 , , , cord-010119-t1x9gknd 1032 11 this this DT cord-010119-t1x9gknd 1032 12 is be VBZ cord-010119-t1x9gknd 1032 13 not not RB cord-010119-t1x9gknd 1032 14 associated associate VBN cord-010119-t1x9gknd 1032 15 with with IN cord-010119-t1x9gknd 1032 16 mutations mutation NNS cord-010119-t1x9gknd 1032 17 in in IN cord-010119-t1x9gknd 1032 18 the the DT cord-010119-t1x9gknd 1032 19 SLC14A1 SLC14A1 NNP cord-010119-t1x9gknd 1032 20 gene gene NN cord-010119-t1x9gknd 1032 21 . . . cord-010119-t1x9gknd 1033 1 The the DT cord-010119-t1x9gknd 1033 2 aims aim NNS cord-010119-t1x9gknd 1033 3 of of IN cord-010119-t1x9gknd 1033 4 the the DT cord-010119-t1x9gknd 1033 5 studies study NNS cord-010119-t1x9gknd 1033 6 was be VBD cord-010119-t1x9gknd 1033 7 to to TO cord-010119-t1x9gknd 1033 8 Identify identify VB cord-010119-t1x9gknd 1033 9 and and CC cord-010119-t1x9gknd 1033 10 characterize characterize VB cord-010119-t1x9gknd 1033 11 the the DT cord-010119-t1x9gknd 1033 12 causative causative JJ cord-010119-t1x9gknd 1033 13 gene gene NN cord-010119-t1x9gknd 1033 14 for for IN cord-010119-t1x9gknd 1033 15 Dominant Dominant NNP cord-010119-t1x9gknd 1033 16 Kidd Kidd NNP cord-010119-t1x9gknd 1033 17 - - HYPH cord-010119-t1x9gknd 1033 18 Null Null NNP cord-010119-t1x9gknd 1033 19 red red JJ cord-010119-t1x9gknd 1033 20 blood blood NN cord-010119-t1x9gknd 1033 21 cell cell NN cord-010119-t1x9gknd 1033 22 phenotype phenotype NN cord-010119-t1x9gknd 1033 23 ( ( -LRB- cord-010119-t1x9gknd 1033 24 InJk InJk NNP cord-010119-t1x9gknd 1033 25 ) ) -RRB- cord-010119-t1x9gknd 1033 26 . . . cord-010119-t1x9gknd 1034 1 Jk Jk NNP cord-010119-t1x9gknd 1034 2 - - HYPH cord-010119-t1x9gknd 1034 3 weak weak JJ cord-010119-t1x9gknd 1034 4 ( ( -LRB- cord-010119-t1x9gknd 1034 5 bold)/ bold)/ XX cord-010119-t1x9gknd 1035 1 Jk Jk NNP cord-010119-t1x9gknd 1035 2 - - HYPH cord-010119-t1x9gknd 1035 3 neg neg JJ cord-010119-t1x9gknd 1035 4 expression expression NN cord-010119-t1x9gknd 1036 1 n n NNP cord-010119-t1x9gknd 1037 1 Within within IN cord-010119-t1x9gknd 1037 2 1 1 CD cord-010119-t1x9gknd 1037 3 aa aa NN cord-010119-t1x9gknd 1037 4 from from IN cord-010119-t1x9gknd 1037 5 TM TM NNP cord-010119-t1x9gknd 1037 6 a a DT cord-010119-t1x9gknd 1037 7 - - HYPH cord-010119-t1x9gknd 1037 8 helix helix NN cord-010119-t1x9gknd 1037 9 end end NN cord-010119-t1x9gknd 1037 10 V76I v76i RB cord-010119-t1x9gknd 1037 11 , , , cord-010119-t1x9gknd 1037 12 A93 A93 NNP cord-010119-t1x9gknd 1037 13 T T NNP cord-010119-t1x9gknd 1037 14 , , , cord-010119-t1x9gknd 1037 15 W171R W171R NNP cord-010119-t1x9gknd 1037 16 , , , cord-010119-t1x9gknd 1037 17 W240R W240R NNP cord-010119-t1x9gknd 1037 18 , , , cord-010119-t1x9gknd 1037 19 G298E G298E NNP cord-010119-t1x9gknd 1037 20 , , , cord-010119-t1x9gknd 1037 21 G299E G299E NNP cord-010119-t1x9gknd 1037 22 , , , cord-010119-t1x9gknd 1037 23 V333D V333D NNP cord-010119-t1x9gknd 1037 24 * * NFP cord-010119-t1x9gknd 1037 25 Cytoplasmic Cytoplasmic NNP cord-010119-t1x9gknd 1037 26 N N NNP cord-010119-t1x9gknd 1037 27 - - HYPH cord-010119-t1x9gknd 1037 28 terminal terminal NN cord-010119-t1x9gknd 1037 29 V10 V10 NNP cord-010119-t1x9gknd 1037 30 M M NNP cord-010119-t1x9gknd 1037 31 , , , cord-010119-t1x9gknd 1037 32 G40S G40S NNP cord-010119-t1x9gknd 1037 33 , , , cord-010119-t1x9gknd 1037 34 E44 E44 NNP cord-010119-t1x9gknd 1037 35 K K NNP cord-010119-t1x9gknd 1037 36 , , , cord-010119-t1x9gknd 1037 37 L45P L45P NNP cord-010119-t1x9gknd 1038 1 In in IN cord-010119-t1x9gknd 1038 2 membrane membrane NN cord-010119-t1x9gknd 1038 3 TM TM NNP cord-010119-t1x9gknd 1038 4 and and CC cord-010119-t1x9gknd 1038 5 urea urea NN cord-010119-t1x9gknd 1038 6 - - HYPH cord-010119-t1x9gknd 1038 7 pore pore NN cord-010119-t1x9gknd 1038 8 a a DT cord-010119-t1x9gknd 1038 9 - - HYPH cord-010119-t1x9gknd 1038 10 helices helix NNS cord-010119-t1x9gknd 1038 11 R64W R64W NNP cord-010119-t1x9gknd 1038 12 , , , cord-010119-t1x9gknd 1038 13 R64Q R64Q NNP cord-010119-t1x9gknd 1038 14 , , , cord-010119-t1x9gknd 1038 15 G65D G65D NNP cord-010119-t1x9gknd 1038 16 , , , cord-010119-t1x9gknd 1038 17 I117 I117 '' cord-010119-t1x9gknd 1038 18 T T NNP cord-010119-t1x9gknd 1038 19 , , , cord-010119-t1x9gknd 1038 20 A183V A183V NNP cord-010119-t1x9gknd 1038 21 , , , cord-010119-t1x9gknd 1038 22 L246R L246R NNP cord-010119-t1x9gknd 1038 23 , , , cord-010119-t1x9gknd 1038 24 A248 a248 NN cord-010119-t1x9gknd 1038 25 T T NNP cord-010119-t1x9gknd 1038 26 ‡ ‡ NN cord-010119-t1x9gknd 1038 27 , , , cord-010119-t1x9gknd 1038 28 A270A A270A NNP cord-010119-t1x9gknd 1038 29 § § NN cord-010119-t1x9gknd 1038 30 , , , cord-010119-t1x9gknd 1038 31 L272F L272F NNP cord-010119-t1x9gknd 1038 32 , , , cord-010119-t1x9gknd 1038 33 N289S N289S NNP cord-010119-t1x9gknd 1038 34 , , , cord-010119-t1x9gknd 1038 35 S291P S291P NNP cord-010119-t1x9gknd 1038 36 , , , cord-010119-t1x9gknd 1038 37 T319 T319 NNP cord-010119-t1x9gknd 1038 38 M M NNP cord-010119-t1x9gknd 1038 39 2/10 2/10 CD cord-010119-t1x9gknd 1039 1 * * NFP cord-010119-t1x9gknd 1039 2 Second second JJ cord-010119-t1x9gknd 1039 3 nucleotide nucleotide JJ cord-010119-t1x9gknd 1039 4 variant variant NN cord-010119-t1x9gknd 1039 5 in in IN cord-010119-t1x9gknd 1039 6 this this DT cord-010119-t1x9gknd 1039 7 allele allele NN cord-010119-t1x9gknd 1039 8 is be VBZ cord-010119-t1x9gknd 1039 9 synonymous synonymous JJ cord-010119-t1x9gknd 1040 1 ( ( -LRB- cord-010119-t1x9gknd 1040 2 p p NN cord-010119-t1x9gknd 1040 3 . . . cord-010119-t1x9gknd 1040 4 P196P P196P NNP cord-010119-t1x9gknd 1040 5 ) ) -RRB- cord-010119-t1x9gknd 1040 6 . . . cord-010119-t1x9gknd 1041 1 ‡Reported ‡reported JJ cord-010119-t1x9gknd 1041 2 as as IN cord-010119-t1x9gknd 1042 1 Jk Jk NNP cord-010119-t1x9gknd 1042 2 - - HYPH cord-010119-t1x9gknd 1042 3 neg neg NNP cord-010119-t1x9gknd 1042 4 but but CC cord-010119-t1x9gknd 1042 5 considered consider VBN cord-010119-t1x9gknd 1042 6 Jk Jk NNP cord-010119-t1x9gknd 1042 7 - - HYPH cord-010119-t1x9gknd 1042 8 weak weak JJ cord-010119-t1x9gknd 1042 9 by by IN cord-010119-t1x9gknd 1042 10 ISBT ISBT NNP cord-010119-t1x9gknd 1042 11 . . . cord-010119-t1x9gknd 1043 1 § § . cord-010119-t1x9gknd 1044 1 Near near IN cord-010119-t1x9gknd 1044 2 splice splice NN cord-010119-t1x9gknd 1044 3 point point NN cord-010119-t1x9gknd 1044 4 . . . cord-010119-t1x9gknd 1045 1 Study Study NNP cord-010119-t1x9gknd 1045 2 Design Design NNP cord-010119-t1x9gknd 1045 3 / / SYM cord-010119-t1x9gknd 1045 4 Method method NN cord-010119-t1x9gknd 1045 5 : : : cord-010119-t1x9gknd 1045 6 We -PRON- PRP cord-010119-t1x9gknd 1045 7 identified identify VBD cord-010119-t1x9gknd 1045 8 several several JJ cord-010119-t1x9gknd 1045 9 families family NNS cord-010119-t1x9gknd 1045 10 with with IN cord-010119-t1x9gknd 1045 11 dominant dominant JJ cord-010119-t1x9gknd 1045 12 inheritance inheritance NN cord-010119-t1x9gknd 1045 13 of of IN cord-010119-t1x9gknd 1045 14 the the DT cord-010119-t1x9gknd 1045 15 Kidd Kidd NNP cord-010119-t1x9gknd 1045 16 - - HYPH cord-010119-t1x9gknd 1045 17 null null JJ cord-010119-t1x9gknd 1045 18 phenotype phenotype NN cord-010119-t1x9gknd 1045 19 in in IN cord-010119-t1x9gknd 1045 20 multiple multiple JJ cord-010119-t1x9gknd 1045 21 kindreds kindred NNS cord-010119-t1x9gknd 1045 22 in in IN cord-010119-t1x9gknd 1045 23 Spain Spain NNP cord-010119-t1x9gknd 1045 24 . . . cord-010119-t1x9gknd 1046 1 We -PRON- PRP cord-010119-t1x9gknd 1046 2 performed perform VBD cord-010119-t1x9gknd 1046 3 whole whole JJ cord-010119-t1x9gknd 1046 4 - - HYPH cord-010119-t1x9gknd 1046 5 genome genome NN cord-010119-t1x9gknd 1046 6 linkage linkage NN cord-010119-t1x9gknd 1046 7 analysis analysis NN cord-010119-t1x9gknd 1046 8 , , , cord-010119-t1x9gknd 1046 9 exome exome NN cord-010119-t1x9gknd 1046 10 sequencing sequencing NN cord-010119-t1x9gknd 1046 11 , , , cord-010119-t1x9gknd 1046 12 expression expression NN cord-010119-t1x9gknd 1046 13 ( ( -LRB- cord-010119-t1x9gknd 1046 14 RT RT NNP cord-010119-t1x9gknd 1046 15 - - HYPH cord-010119-t1x9gknd 1046 16 PCR PCR NNP cord-010119-t1x9gknd 1046 17 and and CC cord-010119-t1x9gknd 1046 18 Western Western NNP cord-010119-t1x9gknd 1046 19 ) ) -RRB- cord-010119-t1x9gknd 1046 20 analyses analysis NNS cord-010119-t1x9gknd 1046 21 , , , cord-010119-t1x9gknd 1046 22 and and CC cord-010119-t1x9gknd 1046 23 Urea urea NN cord-010119-t1x9gknd 1046 24 lysis lysis NN cord-010119-t1x9gknd 1046 25 using use VBG cord-010119-t1x9gknd 1046 26 patients patient NNS cord-010119-t1x9gknd 1046 27 ' ' POS cord-010119-t1x9gknd 1046 28 cells cell NNS cord-010119-t1x9gknd 1046 29 . . . cord-010119-t1x9gknd 1047 1 In in IN cord-010119-t1x9gknd 1047 2 addition addition NN cord-010119-t1x9gknd 1047 3 , , , cord-010119-t1x9gknd 1047 4 two two CD cord-010119-t1x9gknd 1047 5 probands proband NNS cord-010119-t1x9gknd 1047 6 underwent undergo VBD cord-010119-t1x9gknd 1047 7 urine urine NN cord-010119-t1x9gknd 1047 8 concentration concentration NN cord-010119-t1x9gknd 1047 9 tests test NNS cord-010119-t1x9gknd 1047 10 . . . cord-010119-t1x9gknd 1048 1 Results result NNS cord-010119-t1x9gknd 1048 2 / / SYM cord-010119-t1x9gknd 1048 3 Finding finding NN cord-010119-t1x9gknd 1048 4 : : : cord-010119-t1x9gknd 1048 5 Using use VBG cord-010119-t1x9gknd 1048 6 molecular molecular JJ cord-010119-t1x9gknd 1048 7 approaches approach NNS cord-010119-t1x9gknd 1048 8 , , , cord-010119-t1x9gknd 1048 9 we -PRON- PRP cord-010119-t1x9gknd 1048 10 mapped map VBD cord-010119-t1x9gknd 1048 11 the the DT cord-010119-t1x9gknd 1048 12 affected affected JJ cord-010119-t1x9gknd 1048 13 locus locus NN cord-010119-t1x9gknd 1048 14 to to IN cord-010119-t1x9gknd 1048 15 a a DT cord-010119-t1x9gknd 1048 16 5 5 CD cord-010119-t1x9gknd 1048 17 Mbp Mbp NNP cord-010119-t1x9gknd 1048 18 region region NN cord-010119-t1x9gknd 1048 19 in in IN cord-010119-t1x9gknd 1048 20 19q13.11 19q13.11 CD cord-010119-t1x9gknd 1048 21 - - HYPH cord-010119-t1x9gknd 1048 22 13.2 13.2 CD cord-010119-t1x9gknd 1048 23 with with IN cord-010119-t1x9gknd 1048 24 an an DT cord-010119-t1x9gknd 1048 25 LOD lod NN cord-010119-t1x9gknd 1048 26 score score NN cord-010119-t1x9gknd 1048 27 of of IN cord-010119-t1x9gknd 1048 28 9.6 9.6 CD cord-010119-t1x9gknd 1048 29 . . . cord-010119-t1x9gknd 1049 1 Using use VBG cord-010119-t1x9gknd 1049 2 deep deep JJ cord-010119-t1x9gknd 1049 3 sequencing sequencing NN cord-010119-t1x9gknd 1049 4 , , , cord-010119-t1x9gknd 1049 5 we -PRON- PRP cord-010119-t1x9gknd 1049 6 identified identify VBD cord-010119-t1x9gknd 1049 7 a a DT cord-010119-t1x9gknd 1049 8 potential potential JJ cord-010119-t1x9gknd 1049 9 deleterious deleterious JJ cord-010119-t1x9gknd 1049 10 mutation mutation NN cord-010119-t1x9gknd 1049 11 in in IN cord-010119-t1x9gknd 1049 12 the the DT cord-010119-t1x9gknd 1049 13 ZNF850 ZNF850 NNP cord-010119-t1x9gknd 1049 14 gene gene NN cord-010119-t1x9gknd 1049 15 , , , cord-010119-t1x9gknd 1049 16 which which WDT cord-010119-t1x9gknd 1049 17 deletes delete VBZ cord-010119-t1x9gknd 1049 18 84 84 CD cord-010119-t1x9gknd 1049 19 bp bp NN cord-010119-t1x9gknd 1049 20 resulting result VBG cord-010119-t1x9gknd 1049 21 in in IN cord-010119-t1x9gknd 1049 22 loss loss NN cord-010119-t1x9gknd 1049 23 of of IN cord-010119-t1x9gknd 1049 24 an an DT cord-010119-t1x9gknd 1049 25 entire entire JJ cord-010119-t1x9gknd 1049 26 zing zing NN cord-010119-t1x9gknd 1049 27 finger finger NN cord-010119-t1x9gknd 1049 28 domain domain NN cord-010119-t1x9gknd 1049 29 . . . cord-010119-t1x9gknd 1050 1 The the DT cord-010119-t1x9gknd 1050 2 identical identical JJ cord-010119-t1x9gknd 1050 3 del84-ZNF850 del84-znf850 ADD cord-010119-t1x9gknd 1050 4 mutation mutation NN cord-010119-t1x9gknd 1050 5 is be VBZ cord-010119-t1x9gknd 1050 6 present present JJ cord-010119-t1x9gknd 1050 7 in in IN cord-010119-t1x9gknd 1050 8 all all DT cord-010119-t1x9gknd 1050 9 affected affect VBN cord-010119-t1x9gknd 1050 10 individuals individual NNS cord-010119-t1x9gknd 1050 11 , , , cord-010119-t1x9gknd 1050 12 and and CC cord-010119-t1x9gknd 1050 13 is be VBZ cord-010119-t1x9gknd 1050 14 absent absent JJ cord-010119-t1x9gknd 1050 15 from from IN cord-010119-t1x9gknd 1050 16 all all DT cord-010119-t1x9gknd 1050 17 controls control NNS cord-010119-t1x9gknd 1050 18 tested test VBN cord-010119-t1x9gknd 1050 19 ( ( -LRB- cord-010119-t1x9gknd 1050 20 n>2000 n>2000 NN cord-010119-t1x9gknd 1050 21 ) ) -RRB- cord-010119-t1x9gknd 1050 22 . . . cord-010119-t1x9gknd 1051 1 In in IN cord-010119-t1x9gknd 1051 2 addition addition NN cord-010119-t1x9gknd 1051 3 , , , cord-010119-t1x9gknd 1051 4 two two CD cord-010119-t1x9gknd 1051 5 adult adult NN cord-010119-t1x9gknd 1051 6 individuals individual NNS cord-010119-t1x9gknd 1051 7 who who WP cord-010119-t1x9gknd 1051 8 are be VBP cord-010119-t1x9gknd 1051 9 homozygous homozygous JJ cord-010119-t1x9gknd 1051 10 for for IN cord-010119-t1x9gknd 1051 11 the the DT cord-010119-t1x9gknd 1051 12 entire entire JJ cord-010119-t1x9gknd 1051 13 haplotype haplotype NN cord-010119-t1x9gknd 1051 14 including include VBG cord-010119-t1x9gknd 1051 15 the the DT cord-010119-t1x9gknd 1051 16 deletion deletion NN cord-010119-t1x9gknd 1051 17 within within IN cord-010119-t1x9gknd 1051 18 the the DT cord-010119-t1x9gknd 1051 19 ZNF850 ZNF850 NNP cord-010119-t1x9gknd 1051 20 locus locus NN cord-010119-t1x9gknd 1051 21 , , , cord-010119-t1x9gknd 1051 22 thus thus RB cord-010119-t1x9gknd 1051 23 completely completely RB cord-010119-t1x9gknd 1051 24 lacking lack VBG cord-010119-t1x9gknd 1051 25 the the DT cord-010119-t1x9gknd 1051 26 common common JJ cord-010119-t1x9gknd 1051 27 allele allele NN cord-010119-t1x9gknd 1051 28 , , , cord-010119-t1x9gknd 1051 29 were be VBD cord-010119-t1x9gknd 1051 30 identified identify VBN cord-010119-t1x9gknd 1051 31 . . . cord-010119-t1x9gknd 1052 1 We -PRON- PRP cord-010119-t1x9gknd 1052 2 also also RB cord-010119-t1x9gknd 1052 3 obtained obtain VBD cord-010119-t1x9gknd 1052 4 DNA dna NN cord-010119-t1x9gknd 1052 5 from from IN cord-010119-t1x9gknd 1052 6 an an DT cord-010119-t1x9gknd 1052 7 unrelated unrelated JJ cord-010119-t1x9gknd 1052 8 InJk InJk NNP cord-010119-t1x9gknd 1052 9 individual individual NN cord-010119-t1x9gknd 1052 10 reported report VBD cord-010119-t1x9gknd 1052 11 from from IN cord-010119-t1x9gknd 1052 12 Japan Japan NNP cord-010119-t1x9gknd 1052 13 . . . cord-010119-t1x9gknd 1053 1 In in IN cord-010119-t1x9gknd 1053 2 this this DT cord-010119-t1x9gknd 1053 3 individual individual NN cord-010119-t1x9gknd 1053 4 , , , cord-010119-t1x9gknd 1053 5 there there EX cord-010119-t1x9gknd 1053 6 was be VBD cord-010119-t1x9gknd 1053 7 a a DT cord-010119-t1x9gknd 1053 8 similar similar JJ cord-010119-t1x9gknd 1053 9 , , , cord-010119-t1x9gknd 1053 10 though though IN cord-010119-t1x9gknd 1053 11 not not RB cord-010119-t1x9gknd 1053 12 identical identical JJ cord-010119-t1x9gknd 1053 13 , , , cord-010119-t1x9gknd 1053 14 ZNF850del84 ZNF850del84 NNP cord-010119-t1x9gknd 1053 15 . . . cord-010119-t1x9gknd 1054 1 None none NN cord-010119-t1x9gknd 1054 2 of of IN cord-010119-t1x9gknd 1054 3 the the DT cord-010119-t1x9gknd 1054 4 other other JJ cord-010119-t1x9gknd 1054 5 potential potential JJ cord-010119-t1x9gknd 1054 6 genetic genetic JJ cord-010119-t1x9gknd 1054 7 variants variant NNS cord-010119-t1x9gknd 1054 8 identified identify VBN cord-010119-t1x9gknd 1054 9 in in IN cord-010119-t1x9gknd 1054 10 the the DT cord-010119-t1x9gknd 1054 11 Spanish spanish JJ cord-010119-t1x9gknd 1054 12 kindreds kindred NNS cord-010119-t1x9gknd 1054 13 was be VBD cord-010119-t1x9gknd 1054 14 present present JJ cord-010119-t1x9gknd 1054 15 in in IN cord-010119-t1x9gknd 1054 16 the the DT cord-010119-t1x9gknd 1054 17 DNA dna NN cord-010119-t1x9gknd 1054 18 from from IN cord-010119-t1x9gknd 1054 19 the the DT cord-010119-t1x9gknd 1054 20 InJk InJk NNP cord-010119-t1x9gknd 1054 21 individual individual NN cord-010119-t1x9gknd 1054 22 from from IN cord-010119-t1x9gknd 1054 23 Japan Japan NNP cord-010119-t1x9gknd 1054 24 . . . cord-010119-t1x9gknd 1055 1 Consistent consistent JJ cord-010119-t1x9gknd 1055 2 with with IN cord-010119-t1x9gknd 1055 3 the the DT cord-010119-t1x9gknd 1055 4 fact fact NN cord-010119-t1x9gknd 1055 5 that that IN cord-010119-t1x9gknd 1055 6 the the DT cord-010119-t1x9gknd 1055 7 Kidd Kidd NNP cord-010119-t1x9gknd 1055 8 antigen antigen NN cord-010119-t1x9gknd 1055 9 , , , cord-010119-t1x9gknd 1055 10 encoded encode VBN cord-010119-t1x9gknd 1055 11 by by IN cord-010119-t1x9gknd 1055 12 the the DT cord-010119-t1x9gknd 1055 13 SLC14A1gene SLC14A1gene NNP cord-010119-t1x9gknd 1055 14 , , , cord-010119-t1x9gknd 1055 15 is be VBZ cord-010119-t1x9gknd 1055 16 a a DT cord-010119-t1x9gknd 1055 17 urea urea NN cord-010119-t1x9gknd 1055 18 transporter transporter NN cord-010119-t1x9gknd 1055 19 that that WDT cord-010119-t1x9gknd 1055 20 has have VBZ cord-010119-t1x9gknd 1055 21 been be VBN cord-010119-t1x9gknd 1055 22 associated associate VBN cord-010119-t1x9gknd 1055 23 with with IN cord-010119-t1x9gknd 1055 24 renal renal JJ cord-010119-t1x9gknd 1055 25 function function NN cord-010119-t1x9gknd 1055 26 , , , cord-010119-t1x9gknd 1055 27 we -PRON- PRP cord-010119-t1x9gknd 1055 28 found find VBD cord-010119-t1x9gknd 1055 29 that that IN cord-010119-t1x9gknd 1055 30 people people NNS cord-010119-t1x9gknd 1055 31 with with IN cord-010119-t1x9gknd 1055 32 the the DT cord-010119-t1x9gknd 1055 33 ZNF850del84 znf850del84 NN cord-010119-t1x9gknd 1055 34 in in IN cord-010119-t1x9gknd 1055 35 Spain Spain NNP cord-010119-t1x9gknd 1055 36 had have VBD cord-010119-t1x9gknd 1055 37 an an DT cord-010119-t1x9gknd 1055 38 inability inability NN cord-010119-t1x9gknd 1055 39 to to TO cord-010119-t1x9gknd 1055 40 concentrate concentrate VB cord-010119-t1x9gknd 1055 41 their -PRON- PRP$ cord-010119-t1x9gknd 1055 42 urine urine NN cord-010119-t1x9gknd 1055 43 . . . cord-010119-t1x9gknd 1056 1 Conclusion conclusion NN cord-010119-t1x9gknd 1056 2 : : : cord-010119-t1x9gknd 1057 1 A a DT cord-010119-t1x9gknd 1057 2 predicted predict VBN cord-010119-t1x9gknd 1057 3 zinc zinc NN cord-010119-t1x9gknd 1057 4 finger finger NN cord-010119-t1x9gknd 1057 5 deletion deletion NN cord-010119-t1x9gknd 1057 6 at at IN cord-010119-t1x9gknd 1057 7 ZNF850 ZNF850 NNP cord-010119-t1x9gknd 1057 8 , , , cord-010119-t1x9gknd 1057 9 prevalent prevalent JJ cord-010119-t1x9gknd 1057 10 in in IN cord-010119-t1x9gknd 1057 11 Southern Southern NNP cord-010119-t1x9gknd 1057 12 Spain Spain NNP cord-010119-t1x9gknd 1057 13 due due IN cord-010119-t1x9gknd 1057 14 to to IN cord-010119-t1x9gknd 1057 15 a a DT cord-010119-t1x9gknd 1057 16 founder founder NN cord-010119-t1x9gknd 1057 17 mutation mutation NN cord-010119-t1x9gknd 1057 18 , , , cord-010119-t1x9gknd 1057 19 leads lead VBZ cord-010119-t1x9gknd 1057 20 to to IN cord-010119-t1x9gknd 1057 21 UT ut NN cord-010119-t1x9gknd 1057 22 - - HYPH cord-010119-t1x9gknd 1057 23 B1 b1 NN cord-010119-t1x9gknd 1057 24 dysfunction dysfunction NN cord-010119-t1x9gknd 1057 25 and and CC cord-010119-t1x9gknd 1057 26 underlies underlie VBZ cord-010119-t1x9gknd 1057 27 the the DT cord-010119-t1x9gknd 1057 28 dominantly dominantly RB cord-010119-t1x9gknd 1057 29 inherited inherit VBN cord-010119-t1x9gknd 1057 30 Kidd Kidd NNP cord-010119-t1x9gknd 1057 31 - - HYPH cord-010119-t1x9gknd 1057 32 null null JJ cord-010119-t1x9gknd 1057 33 blood blood NN cord-010119-t1x9gknd 1057 34 phenotype phenotype NN cord-010119-t1x9gknd 1057 35 . . . cord-010119-t1x9gknd 1058 1 The the DT cord-010119-t1x9gknd 1058 2 phenotype phenotype NN cord-010119-t1x9gknd 1058 3 associates associate NNS cord-010119-t1x9gknd 1058 4 subnormal subnormal JJ cord-010119-t1x9gknd 1058 5 urine urine NN cord-010119-t1x9gknd 1058 6 concentrating concentrate VBG cord-010119-t1x9gknd 1058 7 ability ability NN cord-010119-t1x9gknd 1058 8 . . . cord-010119-t1x9gknd 1059 1 In in IN cord-010119-t1x9gknd 1059 2 Background Background NNP cord-010119-t1x9gknd 1059 3 / / SYM cord-010119-t1x9gknd 1059 4 Case Case NNP cord-010119-t1x9gknd 1059 5 Studies Studies NNPS cord-010119-t1x9gknd 1059 6 : : : cord-010119-t1x9gknd 1059 7 Di-(2-ethylhexyl di-(2-ethylhexyl NN cord-010119-t1x9gknd 1059 8 ) ) -RRB- cord-010119-t1x9gknd 1059 9 phthalate phthalate NN cord-010119-t1x9gknd 1059 10 ( ( -LRB- cord-010119-t1x9gknd 1059 11 DEHP DEHP NNP cord-010119-t1x9gknd 1059 12 ) ) -RRB- cord-010119-t1x9gknd 1059 13 makes make VBZ cord-010119-t1x9gknd 1059 14 PVC pvc NN cord-010119-t1x9gknd 1059 15 film film NN cord-010119-t1x9gknd 1059 16 flexible flexible JJ cord-010119-t1x9gknd 1059 17 and and CC cord-010119-t1x9gknd 1059 18 useful useful JJ cord-010119-t1x9gknd 1059 19 for for IN cord-010119-t1x9gknd 1059 20 blood blood NN cord-010119-t1x9gknd 1059 21 products product NNS cord-010119-t1x9gknd 1059 22 . . . cord-010119-t1x9gknd 1060 1 During during IN cord-010119-t1x9gknd 1060 2 storage storage NN cord-010119-t1x9gknd 1060 3 , , , cord-010119-t1x9gknd 1060 4 DEHP DEHP NNP cord-010119-t1x9gknd 1060 5 can can MD cord-010119-t1x9gknd 1060 6 leach leach VB cord-010119-t1x9gknd 1060 7 from from IN cord-010119-t1x9gknd 1060 8 the the DT cord-010119-t1x9gknd 1060 9 bag bag NN cord-010119-t1x9gknd 1060 10 film film NN cord-010119-t1x9gknd 1060 11 into into IN cord-010119-t1x9gknd 1060 12 solution solution NN cord-010119-t1x9gknd 1060 13 and and CC cord-010119-t1x9gknd 1060 14 be be VB cord-010119-t1x9gknd 1060 15 metabolized metabolize VBN cord-010119-t1x9gknd 1060 16 . . . cord-010119-t1x9gknd 1061 1 Studies study NNS cord-010119-t1x9gknd 1061 2 in in IN cord-010119-t1x9gknd 1061 3 rodents rodent NNS cord-010119-t1x9gknd 1061 4 have have VBP cord-010119-t1x9gknd 1061 5 suggested suggest VBN cord-010119-t1x9gknd 1061 6 that that IN cord-010119-t1x9gknd 1061 7 exposure exposure NN cord-010119-t1x9gknd 1061 8 to to IN cord-010119-t1x9gknd 1061 9 DEHP DEHP NNP cord-010119-t1x9gknd 1061 10 may may MD cord-010119-t1x9gknd 1061 11 be be VB cord-010119-t1x9gknd 1061 12 associated associate VBN cord-010119-t1x9gknd 1061 13 with with IN cord-010119-t1x9gknd 1061 14 adverse adverse JJ cord-010119-t1x9gknd 1061 15 health health NN cord-010119-t1x9gknd 1061 16 effects effect NNS cord-010119-t1x9gknd 1061 17 , , , cord-010119-t1x9gknd 1061 18 albeit albeit IN cord-010119-t1x9gknd 1061 19 at at IN cord-010119-t1x9gknd 1061 20 high high JJ cord-010119-t1x9gknd 1061 21 dosages dosage NNS cord-010119-t1x9gknd 1061 22 . . . cord-010119-t1x9gknd 1062 1 Attempts attempt NNS cord-010119-t1x9gknd 1062 2 to to TO cord-010119-t1x9gknd 1062 3 find find VB cord-010119-t1x9gknd 1062 4 DEHP dehp NN cord-010119-t1x9gknd 1062 5 alternatives alternative NNS cord-010119-t1x9gknd 1062 6 for for IN cord-010119-t1x9gknd 1062 7 blood blood NN cord-010119-t1x9gknd 1062 8 bags bag NNS cord-010119-t1x9gknd 1062 9 have have VBP cord-010119-t1x9gknd 1062 10 been be VBN cord-010119-t1x9gknd 1062 11 difficult difficult JJ cord-010119-t1x9gknd 1062 12 due due IN cord-010119-t1x9gknd 1062 13 to to IN cord-010119-t1x9gknd 1062 14 the the DT cord-010119-t1x9gknd 1062 15 RBC RBC NNP cord-010119-t1x9gknd 1062 16 membrane membrane NN cord-010119-t1x9gknd 1062 17 - - HYPH cord-010119-t1x9gknd 1062 18 stabilizing stabilize VBG cord-010119-t1x9gknd 1062 19 effect effect NN cord-010119-t1x9gknd 1062 20 of of IN cord-010119-t1x9gknd 1062 21 DEHP DEHP NNP cord-010119-t1x9gknd 1062 22 . . . cord-010119-t1x9gknd 1063 1 Bis(2-ethylhexyl bis(2-ethylhexyl UH cord-010119-t1x9gknd 1063 2 ) ) -RRB- cord-010119-t1x9gknd 1063 3 terephthalate terephthalate NNP cord-010119-t1x9gknd 1063 4 ( ( -LRB- cord-010119-t1x9gknd 1063 5 DEHT DEHT NNP cord-010119-t1x9gknd 1063 6 ) ) -RRB- cord-010119-t1x9gknd 1063 7 a a DT cord-010119-t1x9gknd 1063 8 non non JJ cord-010119-t1x9gknd 1063 9 - - JJ cord-010119-t1x9gknd 1063 10 ortho ortho JJ cord-010119-t1x9gknd 1063 11 - - HYPH cord-010119-t1x9gknd 1063 12 phthalate phthalate NNP cord-010119-t1x9gknd 1063 13 is be VBZ cord-010119-t1x9gknd 1063 14 structurally structurally RB cord-010119-t1x9gknd 1063 15 and and CC cord-010119-t1x9gknd 1063 16 functionally functionally RB cord-010119-t1x9gknd 1063 17 similar similar JJ cord-010119-t1x9gknd 1063 18 to to IN cord-010119-t1x9gknd 1063 19 DEHP DEHP NNP cord-010119-t1x9gknd 1063 20 , , , cord-010119-t1x9gknd 1063 21 but but CC cord-010119-t1x9gknd 1063 22 distinct distinct JJ cord-010119-t1x9gknd 1063 23 from from IN cord-010119-t1x9gknd 1063 24 a a DT cord-010119-t1x9gknd 1063 25 metabolic metabolic JJ cord-010119-t1x9gknd 1063 26 and and CC cord-010119-t1x9gknd 1063 27 toxicological toxicological JJ cord-010119-t1x9gknd 1063 28 standpoint standpoint NN cord-010119-t1x9gknd 1063 29 . . . cord-010119-t1x9gknd 1064 1 DEHT DEHT NNP cord-010119-t1x9gknd 1064 2 can can MD cord-010119-t1x9gknd 1064 3 undergo undergo VB cord-010119-t1x9gknd 1064 4 complete complete JJ cord-010119-t1x9gknd 1064 5 hydrolysis hydrolysis NN cord-010119-t1x9gknd 1064 6 and and CC cord-010119-t1x9gknd 1064 7 has have VBZ cord-010119-t1x9gknd 1064 8 an an DT cord-010119-t1x9gknd 1064 9 excellent excellent JJ cord-010119-t1x9gknd 1064 10 safety safety NN cord-010119-t1x9gknd 1064 11 profile profile NN cord-010119-t1x9gknd 1064 12 ; ; : cord-010119-t1x9gknd 1064 13 it -PRON- PRP cord-010119-t1x9gknd 1064 14 is be VBZ cord-010119-t1x9gknd 1064 15 not not RB cord-010119-t1x9gknd 1064 16 classified classify VBN cord-010119-t1x9gknd 1064 17 as as IN cord-010119-t1x9gknd 1064 18 a a DT cord-010119-t1x9gknd 1064 19 carcinogen carcinogen NN cord-010119-t1x9gknd 1064 20 , , , cord-010119-t1x9gknd 1064 21 mutagen mutagen NN cord-010119-t1x9gknd 1064 22 , , , cord-010119-t1x9gknd 1064 23 reproductive reproductive JJ cord-010119-t1x9gknd 1064 24 toxicant toxicant NN cord-010119-t1x9gknd 1064 25 or or CC cord-010119-t1x9gknd 1064 26 endocrine endocrine JJ cord-010119-t1x9gknd 1064 27 disruptor disruptor NN cord-010119-t1x9gknd 1064 28 . . . cord-010119-t1x9gknd 1065 1 The the DT cord-010119-t1x9gknd 1065 2 study study NN cord-010119-t1x9gknd 1065 3 objective objective NN cord-010119-t1x9gknd 1065 4 was be VBD cord-010119-t1x9gknd 1065 5 to to TO cord-010119-t1x9gknd 1065 6 evaluate evaluate VB cord-010119-t1x9gknd 1065 7 the the DT cord-010119-t1x9gknd 1065 8 quality quality NN cord-010119-t1x9gknd 1065 9 of of IN cord-010119-t1x9gknd 1065 10 fresh fresh JJ cord-010119-t1x9gknd 1065 11 frozen frozen JJ cord-010119-t1x9gknd 1065 12 plasma plasma NN cord-010119-t1x9gknd 1065 13 ( ( -LRB- cord-010119-t1x9gknd 1065 14 FFP FFP NNP cord-010119-t1x9gknd 1065 15 ) ) -RRB- cord-010119-t1x9gknd 1065 16 stored store VBN cord-010119-t1x9gknd 1065 17 in in IN cord-010119-t1x9gknd 1065 18 DEHT DEHT NNP cord-010119-t1x9gknd 1065 19 containers container NNS cord-010119-t1x9gknd 1065 20 versus versus IN cord-010119-t1x9gknd 1065 21 FFP ffp NN cord-010119-t1x9gknd 1065 22 stored store VBN cord-010119-t1x9gknd 1065 23 in in IN cord-010119-t1x9gknd 1065 24 DEHP dehp NN cord-010119-t1x9gknd 1065 25 containers container NNS cord-010119-t1x9gknd 1065 26 at at IN cord-010119-t1x9gknd 1065 27 30 30 CD cord-010119-t1x9gknd 1065 28 days day NNS cord-010119-t1x9gknd 1065 29 and and CC cord-010119-t1x9gknd 1065 30 1 1 CD cord-010119-t1x9gknd 1065 31 year year NN cord-010119-t1x9gknd 1065 32 . . . cord-010119-t1x9gknd 1066 1 Study Study NNP cord-010119-t1x9gknd 1066 2 Design Design NNP cord-010119-t1x9gknd 1066 3 / / SYM cord-010119-t1x9gknd 1066 4 Methods method NNS cord-010119-t1x9gknd 1066 5 : : : cord-010119-t1x9gknd 1067 1 Thirty thirty CD cord-010119-t1x9gknd 1067 2 - - HYPH cord-010119-t1x9gknd 1067 3 six six CD cord-010119-t1x9gknd 1067 4 WB WB NNP cord-010119-t1x9gknd 1067 5 units unit NNS cord-010119-t1x9gknd 1067 6 were be VBD cord-010119-t1x9gknd 1067 7 collected collect VBN cord-010119-t1x9gknd 1067 8 into into IN cord-010119-t1x9gknd 1067 9 CPD CPD NNP cord-010119-t1x9gknd 1067 10 solution solution NN cord-010119-t1x9gknd 1067 11 , , , cord-010119-t1x9gknd 1067 12 leukoreduced leukoreduce VBN cord-010119-t1x9gknd 1067 13 , , , cord-010119-t1x9gknd 1067 14 centrifuged centrifuge VBN cord-010119-t1x9gknd 1067 15 , , , cord-010119-t1x9gknd 1067 16 and and CC cord-010119-t1x9gknd 1067 17 separated separate VBD cord-010119-t1x9gknd 1067 18 into into IN cord-010119-t1x9gknd 1067 19 RBC RBC NNP cord-010119-t1x9gknd 1067 20 and and CC cord-010119-t1x9gknd 1067 21 plasma plasma NN cord-010119-t1x9gknd 1067 22 . . . cord-010119-t1x9gknd 1068 1 ABO ABO NNP cord-010119-t1x9gknd 1068 2 identical identical JJ cord-010119-t1x9gknd 1068 3 plasma plasma NN cord-010119-t1x9gknd 1068 4 units unit NNS cord-010119-t1x9gknd 1068 5 were be VBD cord-010119-t1x9gknd 1068 6 pooled pool VBN cord-010119-t1x9gknd 1068 7 together together RB cord-010119-t1x9gknd 1068 8 in in IN cord-010119-t1x9gknd 1068 9 groups group NNS cord-010119-t1x9gknd 1068 10 of of IN cord-010119-t1x9gknd 1068 11 three three CD cord-010119-t1x9gknd 1068 12 . . . cord-010119-t1x9gknd 1069 1 The the DT cord-010119-t1x9gknd 1069 2 12 12 CD cord-010119-t1x9gknd 1069 3 pools pool NNS cord-010119-t1x9gknd 1069 4 included include VBD cord-010119-t1x9gknd 1069 5 5 5 CD cord-010119-t1x9gknd 1069 6 group group NN cord-010119-t1x9gknd 1069 7 A a NN cord-010119-t1x9gknd 1069 8 , , , cord-010119-t1x9gknd 1069 9 6 6 CD cord-010119-t1x9gknd 1069 10 group group NN cord-010119-t1x9gknd 1069 11 O o NN cord-010119-t1x9gknd 1069 12 and and CC cord-010119-t1x9gknd 1069 13 1 1 CD cord-010119-t1x9gknd 1069 14 group group NN cord-010119-t1x9gknd 1069 15 AB AB NNP cord-010119-t1x9gknd 1069 16 . . . cord-010119-t1x9gknd 1070 1 Each each DT cord-010119-t1x9gknd 1070 2 plasma plasma NN cord-010119-t1x9gknd 1070 3 pool pool NN cord-010119-t1x9gknd 1070 4 was be VBD cord-010119-t1x9gknd 1070 5 weighed weigh VBN cord-010119-t1x9gknd 1070 6 , , , cord-010119-t1x9gknd 1070 7 mixed mix VBN cord-010119-t1x9gknd 1070 8 , , , cord-010119-t1x9gknd 1070 9 sampled sample VBN cord-010119-t1x9gknd 1070 10 , , , cord-010119-t1x9gknd 1070 11 divided divide VBN cord-010119-t1x9gknd 1070 12 into into IN cord-010119-t1x9gknd 1070 13 DEHP DEHP NNP cord-010119-t1x9gknd 1070 14 and and CC cord-010119-t1x9gknd 1070 15 DEHT DEHT NNP cord-010119-t1x9gknd 1070 16 pairs pair NNS cord-010119-t1x9gknd 1070 17 , , , cord-010119-t1x9gknd 1070 18 and and CC cord-010119-t1x9gknd 1070 19 frozen freeze VBN cord-010119-t1x9gknd 1070 20 at at IN cord-010119-t1x9gknd 1070 21 less less JJR cord-010119-t1x9gknd 1070 22 than than IN cord-010119-t1x9gknd 1070 23 -208C -208C , cord-010119-t1x9gknd 1070 24 within within IN cord-010119-t1x9gknd 1070 25 8 8 CD cord-010119-t1x9gknd 1070 26 hours hour NNS cord-010119-t1x9gknd 1070 27 of of IN cord-010119-t1x9gknd 1070 28 collection collection NN cord-010119-t1x9gknd 1070 29 . . . cord-010119-t1x9gknd 1071 1 In in IN cord-010119-t1x9gknd 1071 2 vitro vitro FW cord-010119-t1x9gknd 1071 3 plasma plasma NN cord-010119-t1x9gknd 1071 4 testing testing NN cord-010119-t1x9gknd 1071 5 ( ( -LRB- cord-010119-t1x9gknd 1071 6 PT PT NNP cord-010119-t1x9gknd 1071 7 , , , cord-010119-t1x9gknd 1071 8 aPTT aPTT NNP cord-010119-t1x9gknd 1071 9 , , , cord-010119-t1x9gknd 1071 10 Factor Factor NNP cord-010119-t1x9gknd 1071 11 V V NNP cord-010119-t1x9gknd 1071 12 , , , cord-010119-t1x9gknd 1071 13 Factor Factor NNP cord-010119-t1x9gknd 1071 14 VIII VIII NNP cord-010119-t1x9gknd 1071 15 , , , cord-010119-t1x9gknd 1071 16 Fibrinogen Fibrinogen NNP cord-010119-t1x9gknd 1071 17 , , , cord-010119-t1x9gknd 1071 18 Protein Protein NNP cord-010119-t1x9gknd 1071 19 C C NNP cord-010119-t1x9gknd 1071 20 , , , cord-010119-t1x9gknd 1071 21 and and CC cord-010119-t1x9gknd 1071 22 Protein Protein NNP cord-010119-t1x9gknd 1071 23 S S NNP cord-010119-t1x9gknd 1071 24 ) ) -RRB- cord-010119-t1x9gknd 1071 25 was be VBD cord-010119-t1x9gknd 1071 26 done do VBN cord-010119-t1x9gknd 1071 27 on on IN cord-010119-t1x9gknd 1071 28 Day day NN cord-010119-t1x9gknd 1071 29 0 0 CD cord-010119-t1x9gknd 1072 1 ( ( -LRB- cord-010119-t1x9gknd 1072 2 Pool pool NN cord-010119-t1x9gknd 1072 3 ) ) -RRB- cord-010119-t1x9gknd 1072 4 , , , cord-010119-t1x9gknd 1072 5 Day Day NNP cord-010119-t1x9gknd 1072 6 30 30 CD cord-010119-t1x9gknd 1072 7 , , , cord-010119-t1x9gknd 1072 8 and and CC cord-010119-t1x9gknd 1072 9 1 1 CD cord-010119-t1x9gknd 1072 10 Year year NN cord-010119-t1x9gknd 1072 11 of of IN cord-010119-t1x9gknd 1072 12 storage storage NN cord-010119-t1x9gknd 1072 13 . . . cord-010119-t1x9gknd 1073 1 DEHP DEHP NNP cord-010119-t1x9gknd 1073 2 and and CC cord-010119-t1x9gknd 1073 3 DEHT DEHT NNP cord-010119-t1x9gknd 1073 4 paired pair VBN cord-010119-t1x9gknd 1073 5 plasmas plasma NNS cord-010119-t1x9gknd 1073 6 were be VBD cord-010119-t1x9gknd 1073 7 thawed thaw VBN cord-010119-t1x9gknd 1073 8 and and CC cord-010119-t1x9gknd 1073 9 tested test VBN cord-010119-t1x9gknd 1073 10 at at IN cord-010119-t1x9gknd 1073 11 the the DT cord-010119-t1x9gknd 1073 12 same same JJ cord-010119-t1x9gknd 1073 13 time time NN cord-010119-t1x9gknd 1073 14 . . . cord-010119-t1x9gknd 1074 1 Plasticizer plasticizer NN cord-010119-t1x9gknd 1074 2 concentrations concentration NNS cord-010119-t1x9gknd 1074 3 were be VBD cord-010119-t1x9gknd 1074 4 determined determine VBN cord-010119-t1x9gknd 1074 5 on on IN cord-010119-t1x9gknd 1074 6 Day day NN cord-010119-t1x9gknd 1074 7 0 0 CD cord-010119-t1x9gknd 1074 8 , , , cord-010119-t1x9gknd 1074 9 Day Day NNP cord-010119-t1x9gknd 1074 10 30 30 CD cord-010119-t1x9gknd 1074 11 , , , cord-010119-t1x9gknd 1074 12 and and CC cord-010119-t1x9gknd 1074 13 1 1 CD cord-010119-t1x9gknd 1074 14 Year year NN cord-010119-t1x9gknd 1074 15 of of IN cord-010119-t1x9gknd 1074 16 FFP FFP NNP cord-010119-t1x9gknd 1074 17 storage storage NN cord-010119-t1x9gknd 1074 18 . . . cord-010119-t1x9gknd 1075 1 DEHP DEHP NNP cord-010119-t1x9gknd 1075 2 and and CC cord-010119-t1x9gknd 1075 3 DEHT DEHT NNP cord-010119-t1x9gknd 1075 4 and and CC cord-010119-t1x9gknd 1075 5 their -PRON- PRP$ cord-010119-t1x9gknd 1075 6 monoesters monoester NNS cord-010119-t1x9gknd 1075 7 were be VBD cord-010119-t1x9gknd 1075 8 analyzed analyze VBN cord-010119-t1x9gknd 1075 9 by by IN cord-010119-t1x9gknd 1075 10 liquid liquid JJ cord-010119-t1x9gknd 1075 11 chromatography chromatography NN cord-010119-t1x9gknd 1075 12 - - HYPH cord-010119-t1x9gknd 1075 13 mass mass NN cord-010119-t1x9gknd 1075 14 spectrometry spectrometry NN cord-010119-t1x9gknd 1075 15 . . . cord-010119-t1x9gknd 1076 1 Internal internal JJ cord-010119-t1x9gknd 1076 2 standards standard NNS cord-010119-t1x9gknd 1076 3 were be VBD cord-010119-t1x9gknd 1076 4 deuterated deuterate VBN cord-010119-t1x9gknd 1076 5 - - HYPH cord-010119-t1x9gknd 1076 6 DEHP dehp NN cord-010119-t1x9gknd 1076 7 , , , cord-010119-t1x9gknd 1076 8 MEHP MEHP NNP cord-010119-t1x9gknd 1076 9 , , , cord-010119-t1x9gknd 1076 10 DEHT DEHT NNP cord-010119-t1x9gknd 1076 11 and and CC cord-010119-t1x9gknd 1076 12 MEHT MEHT NNP cord-010119-t1x9gknd 1076 13 . . . cord-010119-t1x9gknd 1077 1 The the DT cord-010119-t1x9gknd 1077 2 lower low JJR cord-010119-t1x9gknd 1077 3 limits limit NNS cord-010119-t1x9gknd 1077 4 of of IN cord-010119-t1x9gknd 1077 5 quantification quantification NN cord-010119-t1x9gknd 1077 6 ( ( -LRB- cord-010119-t1x9gknd 1077 7 LLOQ LLOQ NNP cord-010119-t1x9gknd 1077 8 ) ) -RRB- cord-010119-t1x9gknd 1077 9 were be VBD cord-010119-t1x9gknd 1077 10 : : : cord-010119-t1x9gknd 1077 11 DEHP DEHP NNP cord-010119-t1x9gknd 1077 12 5 5 CD cord-010119-t1x9gknd 1077 13 2.9 2.9 CD cord-010119-t1x9gknd 1077 14 ppm ppm NN cord-010119-t1x9gknd 1077 15 ; ; : cord-010119-t1x9gknd 1077 16 MEHP MEHP NNP cord-010119-t1x9gknd 1077 17 5 5 CD cord-010119-t1x9gknd 1077 18 0.3 0.3 CD cord-010119-t1x9gknd 1077 19 ppm ppm NN cord-010119-t1x9gknd 1077 20 ; ; : cord-010119-t1x9gknd 1077 21 DEHT DEHT NNP cord-010119-t1x9gknd 1077 22 5 5 CD cord-010119-t1x9gknd 1077 23 0.9 0.9 CD cord-010119-t1x9gknd 1077 24 ppm ppm NN cord-010119-t1x9gknd 1077 25 ; ; : cord-010119-t1x9gknd 1077 26 and and CC cord-010119-t1x9gknd 1077 27 MEHT MEHT NNP cord-010119-t1x9gknd 1077 28 5 5 CD cord-010119-t1x9gknd 1077 29 0.2 0.2 CD cord-010119-t1x9gknd 1077 30 ppm ppm NN cord-010119-t1x9gknd 1077 31 . . . cord-010119-t1x9gknd 1078 1 Results result NNS cord-010119-t1x9gknd 1078 2 / / SYM cord-010119-t1x9gknd 1078 3 Findings finding NNS cord-010119-t1x9gknd 1078 4 : : : cord-010119-t1x9gknd 1079 1 Mean mean JJ cord-010119-t1x9gknd 1079 2 and and CC cord-010119-t1x9gknd 1079 3 standard standard JJ cord-010119-t1x9gknd 1079 4 deviation deviation NN cord-010119-t1x9gknd 1079 5 ( ( -LRB- cord-010119-t1x9gknd 1079 6 SD sd NN cord-010119-t1x9gknd 1079 7 ) ) -RRB- cord-010119-t1x9gknd 1079 8 for for IN cord-010119-t1x9gknd 1079 9 key key JJ cord-010119-t1x9gknd 1079 10 clotting clotting NN cord-010119-t1x9gknd 1079 11 factors factor NNS cord-010119-t1x9gknd 1079 12 and and CC cord-010119-t1x9gknd 1079 13 plasticizer plasticizer NN cord-010119-t1x9gknd 1079 14 results result NNS cord-010119-t1x9gknd 1079 15 are be VBP cord-010119-t1x9gknd 1079 16 summarized summarize VBN cord-010119-t1x9gknd 1079 17 in in IN cord-010119-t1x9gknd 1079 18 the the DT cord-010119-t1x9gknd 1079 19 table table NN cord-010119-t1x9gknd 1079 20 . . . cord-010119-t1x9gknd 1080 1 There there EX cord-010119-t1x9gknd 1080 2 was be VBD cord-010119-t1x9gknd 1080 3 no no DT cord-010119-t1x9gknd 1080 4 statistical statistical JJ cord-010119-t1x9gknd 1080 5 difference difference NN cord-010119-t1x9gknd 1080 6 in in IN cord-010119-t1x9gknd 1080 7 any any DT cord-010119-t1x9gknd 1080 8 plasma plasma NN cord-010119-t1x9gknd 1080 9 parameter parameter NN cord-010119-t1x9gknd 1080 10 between between IN cord-010119-t1x9gknd 1080 11 DEHP DEHP NNP cord-010119-t1x9gknd 1080 12 and and CC cord-010119-t1x9gknd 1080 13 DEHT DEHT NNP cord-010119-t1x9gknd 1080 14 bags bag NNS cord-010119-t1x9gknd 1080 15 at at IN cord-010119-t1x9gknd 1080 16 the the DT cord-010119-t1x9gknd 1080 17 same same JJ cord-010119-t1x9gknd 1080 18 time time NN cord-010119-t1x9gknd 1080 19 period period NN cord-010119-t1x9gknd 1080 20 . . . cord-010119-t1x9gknd 1081 1 Factor Factor NNP cord-010119-t1x9gknd 1081 2 VIII VIII NNP cord-010119-t1x9gknd 1081 3 retained retain VBD cord-010119-t1x9gknd 1081 4 greater great JJR cord-010119-t1x9gknd 1081 5 than than IN cord-010119-t1x9gknd 1081 6 80 80 CD cord-010119-t1x9gknd 1081 7 % % NN cord-010119-t1x9gknd 1081 8 of of IN cord-010119-t1x9gknd 1081 9 its -PRON- PRP$ cord-010119-t1x9gknd 1081 10 initial initial JJ cord-010119-t1x9gknd 1081 11 value value NN cord-010119-t1x9gknd 1081 12 . . . cord-010119-t1x9gknd 1082 1 Plasma plasma NN cord-010119-t1x9gknd 1082 2 stored store VBN cord-010119-t1x9gknd 1082 3 in in IN cord-010119-t1x9gknd 1082 4 DEHT DEHT NNP cord-010119-t1x9gknd 1082 5 bags bag NNS cord-010119-t1x9gknd 1082 6 had have VBD cord-010119-t1x9gknd 1082 7 an an DT cord-010119-t1x9gknd 1082 8 average average JJ cord-010119-t1x9gknd 1082 9 plasticizer plasticizer NN cord-010119-t1x9gknd 1082 10 content content NN cord-010119-t1x9gknd 1082 11 90 90 CD cord-010119-t1x9gknd 1082 12 % % NN cord-010119-t1x9gknd 1082 13 lower low JJR cord-010119-t1x9gknd 1082 14 than than IN cord-010119-t1x9gknd 1082 15 that that DT cord-010119-t1x9gknd 1082 16 of of IN cord-010119-t1x9gknd 1082 17 the the DT cord-010119-t1x9gknd 1082 18 DEHP DEHP NNP cord-010119-t1x9gknd 1082 19 bags bag NNS cord-010119-t1x9gknd 1082 20 . . . cord-010119-t1x9gknd 1083 1 Background Background NNP cord-010119-t1x9gknd 1083 2 / / SYM cord-010119-t1x9gknd 1083 3 Case Case NNP cord-010119-t1x9gknd 1083 4 Studies Studies NNPS cord-010119-t1x9gknd 1084 1 : : : cord-010119-t1x9gknd 1084 2 Plasma plasma NN cord-010119-t1x9gknd 1084 3 prevents prevent VBZ cord-010119-t1x9gknd 1084 4 dilutional dilutional JJ cord-010119-t1x9gknd 1084 5 coagulopathy coagulopathy NN cord-010119-t1x9gknd 1084 6 in in IN cord-010119-t1x9gknd 1084 7 trauma trauma NN cord-010119-t1x9gknd 1084 8 victims victim NNS cord-010119-t1x9gknd 1084 9 by by IN cord-010119-t1x9gknd 1084 10 replacing replace VBG cord-010119-t1x9gknd 1084 11 coagulation coagulation NN cord-010119-t1x9gknd 1084 12 factors factor NNS cord-010119-t1x9gknd 1084 13 and and CC cord-010119-t1x9gknd 1084 14 substrates substrate NNS cord-010119-t1x9gknd 1084 15 during during IN cord-010119-t1x9gknd 1084 16 resuscitation resuscitation NN cord-010119-t1x9gknd 1084 17 with with IN cord-010119-t1x9gknd 1084 18 red red JJ cord-010119-t1x9gknd 1084 19 blood blood NN cord-010119-t1x9gknd 1084 20 cells cell NNS cord-010119-t1x9gknd 1084 21 ( ( -LRB- cord-010119-t1x9gknd 1084 22 RBCs rbc NNS cord-010119-t1x9gknd 1084 23 ) ) -RRB- cord-010119-t1x9gknd 1084 24 and/or and/or CC cord-010119-t1x9gknd 1084 25 crystalloid crystalloid NNP cord-010119-t1x9gknd 1084 26 solutions solution NNS cord-010119-t1x9gknd 1084 27 . . . cord-010119-t1x9gknd 1085 1 Spray spray NN cord-010119-t1x9gknd 1085 2 - - HYPH cord-010119-t1x9gknd 1085 3 dried dry VBN cord-010119-t1x9gknd 1085 4 plasma plasma NN cord-010119-t1x9gknd 1085 5 ( ( -LRB- cord-010119-t1x9gknd 1085 6 SpDP SpDP NNP cord-010119-t1x9gknd 1085 7 ) ) -RRB- cord-010119-t1x9gknd 1085 8 is be VBZ cord-010119-t1x9gknd 1085 9 lightweight lightweight JJ cord-010119-t1x9gknd 1085 10 and and CC cord-010119-t1x9gknd 1085 11 can can MD cord-010119-t1x9gknd 1085 12 be be VB cord-010119-t1x9gknd 1085 13 reconstituted reconstitute VBN cord-010119-t1x9gknd 1085 14 in in IN cord-010119-t1x9gknd 1085 15 minutes minute NNS cord-010119-t1x9gknd 1085 16 making make VBG cord-010119-t1x9gknd 1085 17 it -PRON- PRP cord-010119-t1x9gknd 1085 18 ideal ideal JJ cord-010119-t1x9gknd 1085 19 for for IN cord-010119-t1x9gknd 1085 20 use use NN cord-010119-t1x9gknd 1085 21 in in IN cord-010119-t1x9gknd 1085 22 combat combat NN cord-010119-t1x9gknd 1085 23 and and CC cord-010119-t1x9gknd 1085 24 pre pre JJ cord-010119-t1x9gknd 1085 25 - - JJ cord-010119-t1x9gknd 1085 26 hospital hospital JJ cord-010119-t1x9gknd 1085 27 settings setting NNS cord-010119-t1x9gknd 1085 28 to to TO cord-010119-t1x9gknd 1085 29 rapidly rapidly RB cord-010119-t1x9gknd 1085 30 provide provide VB cord-010119-t1x9gknd 1085 31 plasma plasma NN cord-010119-t1x9gknd 1085 32 in in IN cord-010119-t1x9gknd 1085 33 situations situation NNS cord-010119-t1x9gknd 1085 34 where where WRB cord-010119-t1x9gknd 1085 35 it -PRON- PRP cord-010119-t1x9gknd 1085 36 is be VBZ cord-010119-t1x9gknd 1085 37 impractical impractical JJ cord-010119-t1x9gknd 1085 38 to to TO cord-010119-t1x9gknd 1085 39 administer administer VB cord-010119-t1x9gknd 1085 40 fresh fresh JJ cord-010119-t1x9gknd 1085 41 frozen frozen JJ cord-010119-t1x9gknd 1085 42 plasma plasma NN cord-010119-t1x9gknd 1085 43 ( ( -LRB- cord-010119-t1x9gknd 1085 44 FFP FFP NNP cord-010119-t1x9gknd 1085 45 ) ) -RRB- cord-010119-t1x9gknd 1085 46 . . . cord-010119-t1x9gknd 1086 1 The the DT cord-010119-t1x9gknd 1086 2 spray spray NN cord-010119-t1x9gknd 1086 3 - - HYPH cord-010119-t1x9gknd 1086 4 drying drying NN cord-010119-t1x9gknd 1086 5 process process NN cord-010119-t1x9gknd 1086 6 preserves preserve VBZ cord-010119-t1x9gknd 1086 7 coagulation coagulation NN cord-010119-t1x9gknd 1086 8 proteins protein NNS cord-010119-t1x9gknd 1086 9 , , , cord-010119-t1x9gknd 1086 10 but but CC cord-010119-t1x9gknd 1086 11 high high JJ cord-010119-t1x9gknd 1086 12 molecular molecular JJ cord-010119-t1x9gknd 1086 13 weight weight NN cord-010119-t1x9gknd 1086 14 multimers multimer NNS cord-010119-t1x9gknd 1086 15 ( ( -LRB- cord-010119-t1x9gknd 1086 16 HMWM HMWM NNP cord-010119-t1x9gknd 1086 17 ) ) -RRB- cord-010119-t1x9gknd 1086 18 of of IN cord-010119-t1x9gknd 1086 19 von von NNP cord-010119-t1x9gknd 1086 20 Willebrand Willebrand NNP cord-010119-t1x9gknd 1086 21 factor factor NN cord-010119-t1x9gknd 1086 22 ( ( -LRB- cord-010119-t1x9gknd 1086 23 VWF VWF NNP cord-010119-t1x9gknd 1086 24 ) ) -RRB- cord-010119-t1x9gknd 1086 25 are be VBP cord-010119-t1x9gknd 1086 26 decreased decrease VBN cord-010119-t1x9gknd 1086 27 . . . cord-010119-t1x9gknd 1087 1 The the DT cord-010119-t1x9gknd 1087 2 objective objective NN cord-010119-t1x9gknd 1087 3 of of IN cord-010119-t1x9gknd 1087 4 this this DT cord-010119-t1x9gknd 1087 5 study study NN cord-010119-t1x9gknd 1087 6 was be VBD cord-010119-t1x9gknd 1087 7 to to TO cord-010119-t1x9gknd 1087 8 compare compare VB cord-010119-t1x9gknd 1087 9 SpDP SpDP NNP cord-010119-t1x9gknd 1087 10 and and CC cord-010119-t1x9gknd 1087 11 FFP FFP NNP cord-010119-t1x9gknd 1087 12 in in IN cord-010119-t1x9gknd 1087 13 reconstituted reconstitute VBN cord-010119-t1x9gknd 1087 14 whole whole JJ cord-010119-t1x9gknd 1087 15 blood blood NN cord-010119-t1x9gknd 1087 16 ( ( -LRB- cord-010119-t1x9gknd 1087 17 rWB rWB '' cord-010119-t1x9gknd 1087 18 ) ) -RRB- cord-010119-t1x9gknd 1087 19 to to TO cord-010119-t1x9gknd 1087 20 test test VB cord-010119-t1x9gknd 1087 21 the the DT cord-010119-t1x9gknd 1087 22 hypothesis hypothesis NN cord-010119-t1x9gknd 1087 23 that that IN cord-010119-t1x9gknd 1087 24 SpDP SpDP NNP cord-010119-t1x9gknd 1087 25 is be VBZ cord-010119-t1x9gknd 1087 26 not not RB cord-010119-t1x9gknd 1087 27 inferior inferior JJ cord-010119-t1x9gknd 1087 28 to to IN cord-010119-t1x9gknd 1087 29 FFP FFP NNP cord-010119-t1x9gknd 1087 30 in in IN cord-010119-t1x9gknd 1087 31 facilitating facilitate VBG cord-010119-t1x9gknd 1087 32 platelet platelet NN cord-010119-t1x9gknd 1087 33 adhesion adhesion NN cord-010119-t1x9gknd 1087 34 and and CC cord-010119-t1x9gknd 1087 35 thrombus thrombus NN cord-010119-t1x9gknd 1087 36 formation formation NN cord-010119-t1x9gknd 1087 37 . . . cord-010119-t1x9gknd 1088 1 Study Study NNP cord-010119-t1x9gknd 1088 2 Design Design NNP cord-010119-t1x9gknd 1088 3 / / SYM cord-010119-t1x9gknd 1088 4 Method method NN cord-010119-t1x9gknd 1088 5 : : : cord-010119-t1x9gknd 1088 6 Under under IN cord-010119-t1x9gknd 1088 7 an an DT cord-010119-t1x9gknd 1088 8 IRB IRB NNP cord-010119-t1x9gknd 1088 9 - - HYPH cord-010119-t1x9gknd 1088 10 approved approve VBN cord-010119-t1x9gknd 1088 11 protocol protocol NN cord-010119-t1x9gknd 1088 12 , , , cord-010119-t1x9gknd 1088 13 whole whole JJ cord-010119-t1x9gknd 1088 14 blood blood NN cord-010119-t1x9gknd 1088 15 from from IN cord-010119-t1x9gknd 1088 16 healthy healthy JJ cord-010119-t1x9gknd 1088 17 volunteers volunteer NNS cord-010119-t1x9gknd 1088 18 was be VBD cord-010119-t1x9gknd 1088 19 collected collect VBN cord-010119-t1x9gknd 1088 20 into into IN cord-010119-t1x9gknd 1088 21 sodium sodium NN cord-010119-t1x9gknd 1088 22 citrate citrate NN cord-010119-t1x9gknd 1088 23 and and CC cord-010119-t1x9gknd 1088 24 centrifuged centrifuge VBD cord-010119-t1x9gknd 1088 25 at at IN cord-010119-t1x9gknd 1088 26 100 100 CD cord-010119-t1x9gknd 1088 27 g g NN cord-010119-t1x9gknd 1088 28 to to TO cord-010119-t1x9gknd 1088 29 separate separate JJ cord-010119-t1x9gknd 1088 30 RBCs rbc NNS cord-010119-t1x9gknd 1088 31 from from IN cord-010119-t1x9gknd 1088 32 platelet platelet NN cord-010119-t1x9gknd 1088 33 - - HYPH cord-010119-t1x9gknd 1088 34 rich rich JJ cord-010119-t1x9gknd 1088 35 plasma plasma NN cord-010119-t1x9gknd 1088 36 ( ( -LRB- cord-010119-t1x9gknd 1088 37 PRP prp NN cord-010119-t1x9gknd 1088 38 ) ) -RRB- cord-010119-t1x9gknd 1088 39 . . . cord-010119-t1x9gknd 1089 1 PRP PRP NNP cord-010119-t1x9gknd 1089 2 was be VBD cord-010119-t1x9gknd 1089 3 diluted dilute VBN cord-010119-t1x9gknd 1089 4 3-fold 3-fold CD cord-010119-t1x9gknd 1089 5 in in IN cord-010119-t1x9gknd 1089 6 PIPES pipes NN cord-010119-t1x9gknd 1089 7 - - HYPH cord-010119-t1x9gknd 1089 8 Saline Saline NNP cord-010119-t1x9gknd 1089 9 with with IN cord-010119-t1x9gknd 1089 10 1.4mM 1.4mm CD cord-010119-t1x9gknd 1089 11 PGE1 PGE1 NNP cord-010119-t1x9gknd 1089 12 and and CC cord-010119-t1x9gknd 1089 13 centrifuged centrifuge VBD cord-010119-t1x9gknd 1089 14 at at IN cord-010119-t1x9gknd 1089 15 1900 1900 CD cord-010119-t1x9gknd 1090 1 g. g. NNP cord-010119-t1x9gknd 1091 1 The the DT cord-010119-t1x9gknd 1091 2 platelet platelet NN cord-010119-t1x9gknd 1091 3 pellet pellet NN cord-010119-t1x9gknd 1091 4 was be VBD cord-010119-t1x9gknd 1091 5 resuspended resuspend VBN cord-010119-t1x9gknd 1091 6 in in IN cord-010119-t1x9gknd 1091 7 either either DT cord-010119-t1x9gknd 1091 8 SpDP SpDP NNP cord-010119-t1x9gknd 1091 9 or or CC cord-010119-t1x9gknd 1091 10 FFP FFP NNP cord-010119-t1x9gknd 1091 11 and and CC cord-010119-t1x9gknd 1091 12 recombined recombine VBN cord-010119-t1x9gknd 1091 13 with with IN cord-010119-t1x9gknd 1091 14 the the DT cord-010119-t1x9gknd 1091 15 packed packed JJ cord-010119-t1x9gknd 1091 16 RBCs rbc NNS cord-010119-t1x9gknd 1091 17 to to TO cord-010119-t1x9gknd 1091 18 create create VB cord-010119-t1x9gknd 1091 19 rWB rwb NN cord-010119-t1x9gknd 1091 20 with with IN cord-010119-t1x9gknd 1091 21 hematocrit hematocrit NN cord-010119-t1x9gknd 1091 22 of of IN cord-010119-t1x9gknd 1091 23 34 34 CD cord-010119-t1x9gknd 1091 24 - - SYM cord-010119-t1x9gknd 1091 25 40 40 CD cord-010119-t1x9gknd 1091 26 % % NN cord-010119-t1x9gknd 1091 27 and and CC cord-010119-t1x9gknd 1091 28 150,000 150,000 CD cord-010119-t1x9gknd 1091 29 - - SYM cord-010119-t1x9gknd 1091 30 250,000 250,000 CD cord-010119-t1x9gknd 1091 31 platelets platelet NNS cord-010119-t1x9gknd 1091 32 / / SYM cord-010119-t1x9gknd 1091 33 mL. mL. NNS cord-010119-t1x9gknd 1092 1 In in IN cord-010119-t1x9gknd 1092 2 addition addition NN cord-010119-t1x9gknd 1092 3 , , , cord-010119-t1x9gknd 1092 4 two two CD cord-010119-t1x9gknd 1092 5 rWB rwb NN cord-010119-t1x9gknd 1092 6 pairs pair NNS cord-010119-t1x9gknd 1092 7 were be VBD cord-010119-t1x9gknd 1092 8 reconstituted reconstitute VBN cord-010119-t1x9gknd 1092 9 with with IN cord-010119-t1x9gknd 1092 10 SpDP SpDP NNP cord-010119-t1x9gknd 1092 11 diluted diluted JJ cord-010119-t1x9gknd 1092 12 1:1 1:1 CD cord-010119-t1x9gknd 1092 13 ( ( -LRB- cord-010119-t1x9gknd 1092 14 SpDP50 spdp50 NN cord-010119-t1x9gknd 1092 15 % % NN cord-010119-t1x9gknd 1092 16 ) ) -RRB- cord-010119-t1x9gknd 1092 17 with with IN cord-010119-t1x9gknd 1092 18 plasma plasma NN cord-010119-t1x9gknd 1092 19 from from IN cord-010119-t1x9gknd 1092 20 a a DT cord-010119-t1x9gknd 1092 21 patient patient NN cord-010119-t1x9gknd 1092 22 with with IN cord-010119-t1x9gknd 1092 23 Type type NN cord-010119-t1x9gknd 1092 24 3 3 CD cord-010119-t1x9gknd 1092 25 VW VW NNP cord-010119-t1x9gknd 1092 26 disease disease NN cord-010119-t1x9gknd 1092 27 ( ( -LRB- cord-010119-t1x9gknd 1092 28 T3VWD T3VWD NNP cord-010119-t1x9gknd 1092 29 ) ) -RRB- cord-010119-t1x9gknd 1092 30 . . . cord-010119-t1x9gknd 1093 1 Samples sample NNS cord-010119-t1x9gknd 1093 2 were be VBD cord-010119-t1x9gknd 1093 3 fluorescently fluorescently RB cord-010119-t1x9gknd 1093 4 labeled label VBN cord-010119-t1x9gknd 1093 5 with with IN cord-010119-t1x9gknd 1093 6 a a DT cord-010119-t1x9gknd 1093 7 GPIIbIIIa gpiibiiia NN cord-010119-t1x9gknd 1093 8 - - HYPH cord-010119-t1x9gknd 1093 9 specific specific JJ cord-010119-t1x9gknd 1093 10 antibody antibody NN cord-010119-t1x9gknd 1093 11 and and CC cord-010119-t1x9gknd 1093 12 the the DT cord-010119-t1x9gknd 1093 13 sample sample NN cord-010119-t1x9gknd 1093 14 was be VBD cord-010119-t1x9gknd 1093 15 flowed flow VBN cord-010119-t1x9gknd 1093 16 through through IN cord-010119-t1x9gknd 1093 17 a a DT cord-010119-t1x9gknd 1093 18 Type type NN cord-010119-t1x9gknd 1093 19 I -PRON- PRP cord-010119-t1x9gknd 1093 20 collagen collagen NN cord-010119-t1x9gknd 1093 21 - - HYPH cord-010119-t1x9gknd 1093 22 coated coat VBN cord-010119-t1x9gknd 1093 23 microchannel microchannel NN cord-010119-t1x9gknd 1093 24 at at IN cord-010119-t1x9gknd 1093 25 a a DT cord-010119-t1x9gknd 1093 26 shear shear NN cord-010119-t1x9gknd 1093 27 rate rate NN cord-010119-t1x9gknd 1093 28 of of IN cord-010119-t1x9gknd 1093 29 1600 1600 CD cord-010119-t1x9gknd 1093 30 s s NN cord-010119-t1x9gknd 1093 31 -1 -1 NN cord-010119-t1x9gknd 1093 32 for for IN cord-010119-t1x9gknd 1093 33 180 180 CD cord-010119-t1x9gknd 1093 34 seconds second NNS cord-010119-t1x9gknd 1093 35 . . . cord-010119-t1x9gknd 1094 1 Still still RB cord-010119-t1x9gknd 1094 2 images image NNS cord-010119-t1x9gknd 1094 3 of of IN cord-010119-t1x9gknd 1094 4 adherent adherent JJ cord-010119-t1x9gknd 1094 5 platelets platelet NNS cord-010119-t1x9gknd 1094 6 and and CC cord-010119-t1x9gknd 1094 7 thrombi thrombi NNP cord-010119-t1x9gknd 1094 8 were be VBD cord-010119-t1x9gknd 1094 9 captured capture VBN cord-010119-t1x9gknd 1094 10 in in IN cord-010119-t1x9gknd 1094 11 order order NN cord-010119-t1x9gknd 1094 12 to to TO cord-010119-t1x9gknd 1094 13 calculate calculate VB cord-010119-t1x9gknd 1094 14 surface surface NN cord-010119-t1x9gknd 1094 15 area area NN cord-010119-t1x9gknd 1094 16 coverage coverage NN cord-010119-t1x9gknd 1094 17 ( ( -LRB- cord-010119-t1x9gknd 1094 18 SA SA NNP cord-010119-t1x9gknd 1094 19 ) ) -RRB- cord-010119-t1x9gknd 1094 20 along along IN cord-010119-t1x9gknd 1094 21 the the DT cord-010119-t1x9gknd 1094 22 length length NN cord-010119-t1x9gknd 1094 23 of of IN cord-010119-t1x9gknd 1094 24 the the DT cord-010119-t1x9gknd 1094 25 channel channel NN cord-010119-t1x9gknd 1094 26 . . . cord-010119-t1x9gknd 1095 1 Ratio ratio NN cord-010119-t1x9gknd 1095 2 paired pair VBD cord-010119-t1x9gknd 1095 3 t t NN cord-010119-t1x9gknd 1095 4 - - HYPH cord-010119-t1x9gknd 1095 5 test test NN cord-010119-t1x9gknd 1095 6 was be VBD cord-010119-t1x9gknd 1095 7 used use VBN cord-010119-t1x9gknd 1095 8 to to TO cord-010119-t1x9gknd 1095 9 compare compare VB cord-010119-t1x9gknd 1095 10 SA SA NNP cord-010119-t1x9gknd 1095 11 in in IN cord-010119-t1x9gknd 1095 12 samples sample NNS cord-010119-t1x9gknd 1095 13 reconstituted reconstitute VBN cord-010119-t1x9gknd 1095 14 with with IN cord-010119-t1x9gknd 1095 15 SpDP SpDP NNP cord-010119-t1x9gknd 1095 16 vs. vs. FW cord-010119-t1x9gknd 1095 17 FFP FFP NNP cord-010119-t1x9gknd 1095 18 . . . cord-010119-t1x9gknd 1096 1 The the DT cord-010119-t1x9gknd 1096 2 margin margin NN cord-010119-t1x9gknd 1096 3 of of IN cord-010119-t1x9gknd 1096 4 noninferiority noninferiority NN cord-010119-t1x9gknd 1096 5 was be VBD cord-010119-t1x9gknd 1096 6 20 20 CD cord-010119-t1x9gknd 1096 7 % % NN cord-010119-t1x9gknd 1096 8 ( ( -LRB- cord-010119-t1x9gknd 1096 9 SpDP SpDP NNP cord-010119-t1x9gknd 1096 10 / / SYM cord-010119-t1x9gknd 1096 11 FFP FFP NNP cord-010119-t1x9gknd 1096 12 > > XX cord-010119-t1x9gknd 1096 13 0.8 0.8 CD cord-010119-t1x9gknd 1096 14 ) ) -RRB- cord-010119-t1x9gknd 1096 15 . . . cord-010119-t1x9gknd 1097 1 Results result NNS cord-010119-t1x9gknd 1097 2 / / SYM cord-010119-t1x9gknd 1097 3 Finding finding NN cord-010119-t1x9gknd 1097 4 : : : cord-010119-t1x9gknd 1098 1 Six six CD cord-010119-t1x9gknd 1098 2 batches batch NNS cord-010119-t1x9gknd 1098 3 of of IN cord-010119-t1x9gknd 1098 4 SpDP SpDP NNP cord-010119-t1x9gknd 1098 5 / / SYM cord-010119-t1x9gknd 1098 6 FFP FFP NNP cord-010119-t1x9gknd 1098 7 were be VBD cord-010119-t1x9gknd 1098 8 evaluated evaluate VBN cord-010119-t1x9gknd 1098 9 using use VBG cord-010119-t1x9gknd 1098 10 17 17 CD cord-010119-t1x9gknd 1098 11 subjects subject NNS cord-010119-t1x9gknd 1098 12 . . . cord-010119-t1x9gknd 1099 1 There there EX cord-010119-t1x9gknd 1099 2 was be VBD cord-010119-t1x9gknd 1099 3 no no DT cord-010119-t1x9gknd 1099 4 statistical statistical JJ cord-010119-t1x9gknd 1099 5 difference difference NN cord-010119-t1x9gknd 1099 6 between between IN cord-010119-t1x9gknd 1099 7 the the DT cord-010119-t1x9gknd 1099 8 SpDP SpDP NNP cord-010119-t1x9gknd 1099 9 / / SYM cord-010119-t1x9gknd 1099 10 FFP FFP NNP cord-010119-t1x9gknd 1099 11 pairs pair NNS cord-010119-t1x9gknd 1099 12 ( ( -LRB- cord-010119-t1x9gknd 1099 13 P50.7558 P50.7558 NNP cord-010119-t1x9gknd 1099 14 ) ) -RRB- cord-010119-t1x9gknd 1099 15 . . . cord-010119-t1x9gknd 1100 1 The the DT cord-010119-t1x9gknd 1100 2 mean mean JJ cord-010119-t1x9gknd 1100 3 ratio ratio NN cord-010119-t1x9gknd 1100 4 of of IN cord-010119-t1x9gknd 1100 5 SpDP SpDP NNP cord-010119-t1x9gknd 1100 6 / / SYM cord-010119-t1x9gknd 1100 7 FFP FFP NNP cord-010119-t1x9gknd 1100 8 was be VBD cord-010119-t1x9gknd 1100 9 1.21 1.21 CD cord-010119-t1x9gknd 1100 10 with with IN cord-010119-t1x9gknd 1100 11 a a DT cord-010119-t1x9gknd 1100 12 95 95 CD cord-010119-t1x9gknd 1100 13 % % NN cord-010119-t1x9gknd 1100 14 CI ci NN cord-010119-t1x9gknd 1100 15 of of IN cord-010119-t1x9gknd 1100 16 0.84 0.84 CD cord-010119-t1x9gknd 1100 17 -1.57 -1.57 CD cord-010119-t1x9gknd 1100 18 . . . cord-010119-t1x9gknd 1101 1 Comparing compare VBG cord-010119-t1x9gknd 1101 2 SpDP SpDP NNP cord-010119-t1x9gknd 1101 3 vs. vs. FW cord-010119-t1x9gknd 1101 4 SpDP50 SpDP50 NNP cord-010119-t1x9gknd 1101 5 % % NN cord-010119-t1x9gknd 1101 6 , , , cord-010119-t1x9gknd 1101 7 there there EX cord-010119-t1x9gknd 1101 8 was be VBD cord-010119-t1x9gknd 1101 9 no no DT cord-010119-t1x9gknd 1101 10 difference difference NN cord-010119-t1x9gknd 1101 11 ( ( -LRB- cord-010119-t1x9gknd 1101 12 median median JJ cord-010119-t1x9gknd 1101 13 ratio ratio NN cord-010119-t1x9gknd 1101 14 5 5 CD cord-010119-t1x9gknd 1101 15 1.045 1.045 CD cord-010119-t1x9gknd 1101 16 , , , cord-010119-t1x9gknd 1101 17 range range NN cord-010119-t1x9gknd 1101 18 : : : cord-010119-t1x9gknd 1101 19 0.95 0.95 CD cord-010119-t1x9gknd 1101 20 - - SYM cord-010119-t1x9gknd 1101 21 1.14 1.14 CD cord-010119-t1x9gknd 1101 22 ) ) -RRB- cord-010119-t1x9gknd 1101 23 in in IN cord-010119-t1x9gknd 1101 24 SA SA NNP cord-010119-t1x9gknd 1101 25 . . . cord-010119-t1x9gknd 1102 1 Two two CD cord-010119-t1x9gknd 1102 2 - - HYPH cord-010119-t1x9gknd 1102 3 way way NN cord-010119-t1x9gknd 1102 4 ANOVA ANOVA NNP cord-010119-t1x9gknd 1102 5 demonstrated demonstrate VBD cord-010119-t1x9gknd 1102 6 that that DT cord-010119-t1x9gknd 1102 7 batch batch NN cord-010119-t1x9gknd 1102 8 did do VBD cord-010119-t1x9gknd 1102 9 not not RB cord-010119-t1x9gknd 1102 10 significantly significantly RB cord-010119-t1x9gknd 1102 11 affect affect VB cord-010119-t1x9gknd 1102 12 ratio ratio NN cord-010119-t1x9gknd 1102 13 of of IN cord-010119-t1x9gknd 1102 14 SA SA NNP cord-010119-t1x9gknd 1102 15 in in IN cord-010119-t1x9gknd 1102 16 SpDP SpDP NNP cord-010119-t1x9gknd 1102 17 vs. vs. FW cord-010119-t1x9gknd 1102 18 FFP FFP NNP cord-010119-t1x9gknd 1102 19 . . . cord-010119-t1x9gknd 1103 1 Conclusion conclusion NN cord-010119-t1x9gknd 1103 2 : : : cord-010119-t1x9gknd 1103 3 SpDP SpDP NNP cord-010119-t1x9gknd 1103 4 , , , cord-010119-t1x9gknd 1103 5 despite despite IN cord-010119-t1x9gknd 1103 6 a a DT cord-010119-t1x9gknd 1103 7 decrease decrease NN cord-010119-t1x9gknd 1103 8 of of IN cord-010119-t1x9gknd 1103 9 VWF VWF NNP cord-010119-t1x9gknd 1103 10 HMWM HMWM NNP cord-010119-t1x9gknd 1103 11 , , , cord-010119-t1x9gknd 1103 12 was be VBD cord-010119-t1x9gknd 1103 13 not not RB cord-010119-t1x9gknd 1103 14 inferior inferior JJ cord-010119-t1x9gknd 1103 15 to to IN cord-010119-t1x9gknd 1103 16 FFP ffp VB cord-010119-t1x9gknd 1103 17 in in IN cord-010119-t1x9gknd 1103 18 ability ability NN cord-010119-t1x9gknd 1103 19 to to TO cord-010119-t1x9gknd 1103 20 support support VB cord-010119-t1x9gknd 1103 21 platelet platelet NN cord-010119-t1x9gknd 1103 22 adhesion adhesion NN cord-010119-t1x9gknd 1103 23 and and CC cord-010119-t1x9gknd 1103 24 thrombus thrombus NN cord-010119-t1x9gknd 1103 25 formation formation NN cord-010119-t1x9gknd 1103 26 . . . cord-010119-t1x9gknd 1104 1 On on IN cord-010119-t1x9gknd 1104 2 average average JJ cord-010119-t1x9gknd 1104 3 , , , cord-010119-t1x9gknd 1104 4 SA SA NNP cord-010119-t1x9gknd 1104 5 in in IN cord-010119-t1x9gknd 1104 6 samples sample NNS cord-010119-t1x9gknd 1104 7 reconstituted reconstitute VBN cord-010119-t1x9gknd 1104 8 with with IN cord-010119-t1x9gknd 1104 9 SpDP SpDP NNP cord-010119-t1x9gknd 1104 10 was be VBD cord-010119-t1x9gknd 1104 11 20 20 CD cord-010119-t1x9gknd 1104 12 % % NN cord-010119-t1x9gknd 1104 13 greater great JJR cord-010119-t1x9gknd 1104 14 than than IN cord-010119-t1x9gknd 1104 15 in in IN cord-010119-t1x9gknd 1104 16 samples sample NNS cord-010119-t1x9gknd 1104 17 reconstituted reconstitute VBN cord-010119-t1x9gknd 1104 18 with with IN cord-010119-t1x9gknd 1104 19 FFP FFP NNP cord-010119-t1x9gknd 1104 20 . . . cord-010119-t1x9gknd 1105 1 The the DT cord-010119-t1x9gknd 1105 2 lower low JJR cord-010119-t1x9gknd 1105 3 limit limit NN cord-010119-t1x9gknd 1105 4 of of IN cord-010119-t1x9gknd 1105 5 the the DT cord-010119-t1x9gknd 1105 6 95 95 CD cord-010119-t1x9gknd 1105 7 th th XX cord-010119-t1x9gknd 1105 8 % % NN cord-010119-t1x9gknd 1105 9 CI CI NNP cord-010119-t1x9gknd 1105 10 is be VBZ cord-010119-t1x9gknd 1105 11 a a DT cord-010119-t1x9gknd 1105 12 difference difference NN cord-010119-t1x9gknd 1105 13 of of IN cord-010119-t1x9gknd 1105 14 16 16 CD cord-010119-t1x9gknd 1105 15 % % NN cord-010119-t1x9gknd 1105 16 , , , cord-010119-t1x9gknd 1105 17 which which WDT cord-010119-t1x9gknd 1105 18 is be VBZ cord-010119-t1x9gknd 1105 19 less less JJR cord-010119-t1x9gknd 1105 20 than than IN cord-010119-t1x9gknd 1105 21 the the DT cord-010119-t1x9gknd 1105 22 a a DT cord-010119-t1x9gknd 1105 23 priori priori FW cord-010119-t1x9gknd 1105 24 determined determined JJ cord-010119-t1x9gknd 1105 25 margin margin NN cord-010119-t1x9gknd 1105 26 of of IN cord-010119-t1x9gknd 1105 27 noninferiority noninferiority NN cord-010119-t1x9gknd 1105 28 of of IN cord-010119-t1x9gknd 1105 29 20 20 CD cord-010119-t1x9gknd 1105 30 % % NN cord-010119-t1x9gknd 1105 31 . . . cord-010119-t1x9gknd 1106 1 Even even RB cord-010119-t1x9gknd 1106 2 with with IN cord-010119-t1x9gknd 1106 3 50 50 CD cord-010119-t1x9gknd 1106 4 % % NN cord-010119-t1x9gknd 1106 5 dilution dilution NN cord-010119-t1x9gknd 1106 6 with with IN cord-010119-t1x9gknd 1106 7 T3VWD T3VWD NNP cord-010119-t1x9gknd 1106 8 plasma plasma NN cord-010119-t1x9gknd 1106 9 , , , cord-010119-t1x9gknd 1106 10 there there EX cord-010119-t1x9gknd 1106 11 was be VBD cord-010119-t1x9gknd 1106 12 no no DT cord-010119-t1x9gknd 1106 13 reduction reduction NN cord-010119-t1x9gknd 1106 14 in in IN cord-010119-t1x9gknd 1106 15 platelet platelet NN cord-010119-t1x9gknd 1106 16 adhesion adhesion NN cord-010119-t1x9gknd 1106 17 and and CC cord-010119-t1x9gknd 1106 18 thrombus thrombus NN cord-010119-t1x9gknd 1106 19 formation formation NN cord-010119-t1x9gknd 1106 20 in in IN cord-010119-t1x9gknd 1106 21 the the DT cord-010119-t1x9gknd 1106 22 SpDP SpDP NNP cord-010119-t1x9gknd 1106 23 rWB rwb NN cord-010119-t1x9gknd 1106 24 samples sample NNS cord-010119-t1x9gknd 1106 25 . . . cord-010119-t1x9gknd 1107 1 These these DT cord-010119-t1x9gknd 1107 2 data datum NNS cord-010119-t1x9gknd 1107 3 support support VBP cord-010119-t1x9gknd 1107 4 the the DT cord-010119-t1x9gknd 1107 5 development development NN cord-010119-t1x9gknd 1107 6 of of IN cord-010119-t1x9gknd 1107 7 in in IN cord-010119-t1x9gknd 1107 8 - - HYPH cord-010119-t1x9gknd 1107 9 human human JJ cord-010119-t1x9gknd 1107 10 studies study NNS cord-010119-t1x9gknd 1107 11 to to TO cord-010119-t1x9gknd 1107 12 evaluate evaluate VB cord-010119-t1x9gknd 1107 13 the the DT cord-010119-t1x9gknd 1107 14 efficacy efficacy NN cord-010119-t1x9gknd 1107 15 and and CC cord-010119-t1x9gknd 1107 16 safety safety NN cord-010119-t1x9gknd 1107 17 of of IN cord-010119-t1x9gknd 1107 18 SpDP SpDP NNP cord-010119-t1x9gknd 1107 19 in in IN cord-010119-t1x9gknd 1107 20 preventing prevent VBG cord-010119-t1x9gknd 1107 21 and and CC cord-010119-t1x9gknd 1107 22 reversing reverse VBG cord-010119-t1x9gknd 1107 23 trauma trauma NN cord-010119-t1x9gknd 1107 24 - - HYPH cord-010119-t1x9gknd 1107 25 related relate VBN cord-010119-t1x9gknd 1107 26 coagulopathy coagulopathy NN cord-010119-t1x9gknd 1107 27 . . . cord-010119-t1x9gknd 1108 1 Spray spray NN cord-010119-t1x9gknd 1108 2 - - HYPH cord-010119-t1x9gknd 1108 3 Dried Dried NNP cord-010119-t1x9gknd 1108 4 Plasma Plasma NNP cord-010119-t1x9gknd 1108 5 Deficient Deficient NNP cord-010119-t1x9gknd 1108 6 in in IN cord-010119-t1x9gknd 1108 7 High high JJ cord-010119-t1x9gknd 1108 8 Molecular Molecular NNP cord-010119-t1x9gknd 1108 9 Weight Weight NNP cord-010119-t1x9gknd 1108 10 Multimers Multimers NNP cord-010119-t1x9gknd 1108 11 of of IN cord-010119-t1x9gknd 1108 12 Von Von NNP cord-010119-t1x9gknd 1108 13 Willebrand Willebrand NNP cord-010119-t1x9gknd 1108 14 Factor Factor NNP cord-010119-t1x9gknd 1108 15 Retains retain VBZ cord-010119-t1x9gknd 1108 16 Hemostatic Hemostatic NNP cord-010119-t1x9gknd 1108 17 Properties Properties NNP cord-010119-t1x9gknd 1109 1 Michael Michael NNP cord-010119-t1x9gknd 1109 2 A. a. NN cord-010119-t1x9gknd 1109 3 Meledeo Meledeo NNP cord-010119-t1x9gknd 1109 4 * * NFP cord-010119-t1x9gknd 1109 5 1 1 CD cord-010119-t1x9gknd 1109 6 , , , cord-010119-t1x9gknd 1110 1 Qiyong Qiyong NNP cord-010119-t1x9gknd 1110 2 Peter Peter NNP cord-010119-t1x9gknd 1110 3 Liu Liu NNP cord-010119-t1x9gknd 1110 4 2 2 CD cord-010119-t1x9gknd 1110 5 , , , cord-010119-t1x9gknd 1110 6 Grantham Grantham NNP cord-010119-t1x9gknd 1110 7 C. C. NNP cord-010119-t1x9gknd 1110 8 Peltier Peltier NNP cord-010119-t1x9gknd 1110 9 1 1 CD cord-010119-t1x9gknd 1110 10 , , , cord-010119-t1x9gknd 1110 11 Ryan Ryan NNP cord-010119-t1x9gknd 1110 12 C. C. NNP cord-010119-t1x9gknd 1110 13 Carney Carney NNP cord-010119-t1x9gknd 1110 14 2 2 CD cord-010119-t1x9gknd 1110 15 , , , cord-010119-t1x9gknd 1110 16 Ashley Ashley NNP cord-010119-t1x9gknd 1110 17 S. S. NNP cord-010119-t1x9gknd 1110 18 Taylor Taylor NNP cord-010119-t1x9gknd 1110 19 1 1 CD cord-010119-t1x9gknd 1110 20 , , , cord-010119-t1x9gknd 1110 21 Colby Colby NNP cord-010119-t1x9gknd 1110 22 S. S. NNP cord-010119-t1x9gknd 1110 23 McIntosh McIntosh NNP cord-010119-t1x9gknd 1110 24 1 1 CD cord-010119-t1x9gknd 1110 25 , , , cord-010119-t1x9gknd 1110 26 James James NNP cord-010119-t1x9gknd 1110 27 A. A. NNP cord-010119-t1x9gknd 1110 28 Bynum Bynum NNP cord-010119-t1x9gknd 1110 29 1 1 CD cord-010119-t1x9gknd 1110 30 and and CC cord-010119-t1x9gknd 1110 31 Andrew Andrew NNP cord-010119-t1x9gknd 1110 32 P P NNP cord-010119-t1x9gknd 1110 33 Cap Cap NNP cord-010119-t1x9gknd 1110 34 1 1 CD cord-010119-t1x9gknd 1110 35 . . . cord-010119-t1x9gknd 1111 1 1 1 CD cord-010119-t1x9gknd 1111 2 U.S. U.S. NNP cord-010119-t1x9gknd 1111 3 Army Army NNP cord-010119-t1x9gknd 1111 4 Institute Institute NNP cord-010119-t1x9gknd 1111 5 of of IN cord-010119-t1x9gknd 1111 6 Surgical Surgical NNP cord-010119-t1x9gknd 1111 7 Research Research NNP cord-010119-t1x9gknd 1111 8 , , , cord-010119-t1x9gknd 1111 9 2 2 CD cord-010119-t1x9gknd 1111 10 Velico Velico NNP cord-010119-t1x9gknd 1111 11 Medical Medical NNP cord-010119-t1x9gknd 1111 12 Inc Inc NNP cord-010119-t1x9gknd 1111 13 Background Background NNP cord-010119-t1x9gknd 1111 14 / / SYM cord-010119-t1x9gknd 1111 15 Case Case NNP cord-010119-t1x9gknd 1111 16 Studies Studies NNPS cord-010119-t1x9gknd 1111 17 : : : cord-010119-t1x9gknd 1111 18 Restoring restore VBG cord-010119-t1x9gknd 1111 19 coagulation coagulation NN cord-010119-t1x9gknd 1111 20 factors factor NNS cord-010119-t1x9gknd 1111 21 is be VBZ cord-010119-t1x9gknd 1111 22 key key JJ cord-010119-t1x9gknd 1111 23 in in IN cord-010119-t1x9gknd 1111 24 acute acute JJ cord-010119-t1x9gknd 1111 25 resuscitation resuscitation NN cord-010119-t1x9gknd 1111 26 after after IN cord-010119-t1x9gknd 1111 27 traumatic traumatic JJ cord-010119-t1x9gknd 1111 28 hemorrhage hemorrhage NN cord-010119-t1x9gknd 1111 29 , , , cord-010119-t1x9gknd 1111 30 but but CC cord-010119-t1x9gknd 1111 31 blood blood NN cord-010119-t1x9gknd 1111 32 products product NNS cord-010119-t1x9gknd 1111 33 are be VBP cord-010119-t1x9gknd 1111 34 frequently frequently RB cord-010119-t1x9gknd 1111 35 unavailable unavailable JJ cord-010119-t1x9gknd 1111 36 in in IN cord-010119-t1x9gknd 1111 37 emergency emergency NN cord-010119-t1x9gknd 1111 38 response response NN cord-010119-t1x9gknd 1111 39 due due IN cord-010119-t1x9gknd 1111 40 to to IN cord-010119-t1x9gknd 1111 41 shelf shelf NN cord-010119-t1x9gknd 1111 42 - - HYPH cord-010119-t1x9gknd 1111 43 life life NN cord-010119-t1x9gknd 1111 44 restrictions restriction NNS cord-010119-t1x9gknd 1111 45 and and CC cord-010119-t1x9gknd 1111 46 storage storage NN cord-010119-t1x9gknd 1111 47 needs need NNS cord-010119-t1x9gknd 1111 48 . . . cord-010119-t1x9gknd 1112 1 A a DT cord-010119-t1x9gknd 1112 2 single single JJ cord-010119-t1x9gknd 1112 3 unit unit NN cord-010119-t1x9gknd 1112 4 spray spray NN cord-010119-t1x9gknd 1112 5 dried dry VBD cord-010119-t1x9gknd 1112 6 plasma plasma NN cord-010119-t1x9gknd 1112 7 ( ( -LRB- cord-010119-t1x9gknd 1112 8 SpDP SpDP NNP cord-010119-t1x9gknd 1112 9 ) ) -RRB- cord-010119-t1x9gknd 1112 10 process process NN cord-010119-t1x9gknd 1112 11 has have VBZ cord-010119-t1x9gknd 1112 12 been be VBN cord-010119-t1x9gknd 1112 13 developed develop VBN cord-010119-t1x9gknd 1112 14 that that WDT cord-010119-t1x9gknd 1112 15 produces produce VBZ cord-010119-t1x9gknd 1112 16 a a DT cord-010119-t1x9gknd 1112 17 long long RB cord-010119-t1x9gknd 1112 18 - - HYPH cord-010119-t1x9gknd 1112 19 lived live VBN cord-010119-t1x9gknd 1112 20 and and CC cord-010119-t1x9gknd 1112 21 readily readily RB cord-010119-t1x9gknd 1112 22 stored store VBN cord-010119-t1x9gknd 1112 23 product product NN cord-010119-t1x9gknd 1112 24 that that WDT cord-010119-t1x9gknd 1112 25 has have VBZ cord-010119-t1x9gknd 1112 26 a a DT cord-010119-t1x9gknd 1112 27 reduction reduction NN cord-010119-t1x9gknd 1112 28 in in IN cord-010119-t1x9gknd 1112 29 high high JJ cord-010119-t1x9gknd 1112 30 molecular molecular JJ cord-010119-t1x9gknd 1112 31 weight weight NN cord-010119-t1x9gknd 1112 32 multimers multimer NNS cord-010119-t1x9gknd 1112 33 of of IN cord-010119-t1x9gknd 1112 34 von von NNP cord-010119-t1x9gknd 1112 35 Willebrand Willebrand NNP cord-010119-t1x9gknd 1112 36 factor factor NN cord-010119-t1x9gknd 1112 37 ( ( -LRB- cord-010119-t1x9gknd 1112 38 vWF vWF NNP cord-010119-t1x9gknd 1112 39 ) ) -RRB- cord-010119-t1x9gknd 1112 40 and and CC cord-010119-t1x9gknd 1112 41 an an DT cord-010119-t1x9gknd 1112 42 increase increase NN cord-010119-t1x9gknd 1112 43 in in IN cord-010119-t1x9gknd 1112 44 low low JJ cord-010119-t1x9gknd 1112 45 molecular molecular JJ cord-010119-t1x9gknd 1112 46 weight weight NN cord-010119-t1x9gknd 1112 47 multimers multimer NNS cord-010119-t1x9gknd 1112 48 . . . cord-010119-t1x9gknd 1113 1 vWF vWF NNP cord-010119-t1x9gknd 1113 2 is be VBZ cord-010119-t1x9gknd 1113 3 critical critical JJ cord-010119-t1x9gknd 1113 4 in in IN cord-010119-t1x9gknd 1113 5 platelet platelet NN cord-010119-t1x9gknd 1113 6 adhesion adhesion NN cord-010119-t1x9gknd 1113 7 and and CC cord-010119-t1x9gknd 1113 8 thrombus thrombus NN cord-010119-t1x9gknd 1113 9 formation formation NN cord-010119-t1x9gknd 1113 10 . . . cord-010119-t1x9gknd 1114 1 Following follow VBG cord-010119-t1x9gknd 1114 2 work work NN cord-010119-t1x9gknd 1114 3 demonstrating demonstrate VBG cord-010119-t1x9gknd 1114 4 enhanced enhance VBN cord-010119-t1x9gknd 1114 5 function function NN cord-010119-t1x9gknd 1114 6 with with IN cord-010119-t1x9gknd 1114 7 use use NN cord-010119-t1x9gknd 1114 8 of of IN cord-010119-t1x9gknd 1114 9 glycine glycine NN cord-010119-t1x9gknd 1114 10 - - HYPH cord-010119-t1x9gknd 1114 11 based base VBN cord-010119-t1x9gknd 1114 12 reconstitution reconstitution NN cord-010119-t1x9gknd 1114 13 solutions solution NNS cord-010119-t1x9gknd 1114 14 for for IN cord-010119-t1x9gknd 1114 15 SpDP SpDP NNP cord-010119-t1x9gknd 1114 16 , , , cord-010119-t1x9gknd 1114 17 this this DT cord-010119-t1x9gknd 1114 18 study study NN cord-010119-t1x9gknd 1114 19 examines examine VBZ cord-010119-t1x9gknd 1114 20 two two CD cord-010119-t1x9gknd 1114 21 different different JJ cord-010119-t1x9gknd 1114 22 SpDP SpDP NNP cord-010119-t1x9gknd 1114 23 pretreatment pretreatment NN cord-010119-t1x9gknd 1114 24 conditions condition NNS cord-010119-t1x9gknd 1114 25 . . . cord-010119-t1x9gknd 1115 1 Study Study NNP cord-010119-t1x9gknd 1115 2 Design Design NNP cord-010119-t1x9gknd 1115 3 / / SYM cord-010119-t1x9gknd 1115 4 Method method NN cord-010119-t1x9gknd 1115 5 : : : cord-010119-t1x9gknd 1116 1 The the DT cord-010119-t1x9gknd 1116 2 samples sample NNS cord-010119-t1x9gknd 1116 3 were be VBD cord-010119-t1x9gknd 1116 4 : : : cord-010119-t1x9gknd 1116 5 ( ( -LRB- cord-010119-t1x9gknd 1116 6 1 1 LS cord-010119-t1x9gknd 1116 7 ) ) -RRB- cord-010119-t1x9gknd 1116 8 FFP ffp NN cord-010119-t1x9gknd 1116 9 ; ; : cord-010119-t1x9gknd 1116 10 ( ( -LRB- cord-010119-t1x9gknd 1116 11 2 2 LS cord-010119-t1x9gknd 1116 12 ) ) -RRB- cord-010119-t1x9gknd 1116 13 FFP ffp NN cord-010119-t1x9gknd 1116 14 with with IN cord-010119-t1x9gknd 1116 15 70mM 70mm CD cord-010119-t1x9gknd 1116 16 glycine glycine NN cord-010119-t1x9gknd 1116 17 ; ; : cord-010119-t1x9gknd 1116 18 ( ( -LRB- cord-010119-t1x9gknd 1116 19 3 3 LS cord-010119-t1x9gknd 1116 20 ) ) -RRB- cord-010119-t1x9gknd 1116 21 regular regular JJ cord-010119-t1x9gknd 1116 22 SpDP SpDP NNP cord-010119-t1x9gknd 1116 23 without without IN cord-010119-t1x9gknd 1116 24 pretreatment pretreatment NN cord-010119-t1x9gknd 1116 25 ( ( -LRB- cord-010119-t1x9gknd 1116 26 rSpDP rspdp NN cord-010119-t1x9gknd 1116 27 ) ) -RRB- cord-010119-t1x9gknd 1116 28 , , , cord-010119-t1x9gknd 1116 29 rehydrated rehydrate VBN cord-010119-t1x9gknd 1116 30 with with IN cord-010119-t1x9gknd 1116 31 glycine glycine NN cord-010119-t1x9gknd 1116 32 - - HYPH cord-010119-t1x9gknd 1116 33 HCl hcl NN cord-010119-t1x9gknd 1116 34 : : : cord-010119-t1x9gknd 1116 35 glycine glycine NN cord-010119-t1x9gknd 1116 36 ; ; : cord-010119-t1x9gknd 1116 37 ( ( -LRB- cord-010119-t1x9gknd 1116 38 4 4 LS cord-010119-t1x9gknd 1116 39 ) ) -RRB- cord-010119-t1x9gknd 1116 40 SpDP SpDP VBN cord-010119-t1x9gknd 1116 41 pretreated pretreate VBD cord-010119-t1x9gknd 1116 42 with with IN cord-010119-t1x9gknd 1116 43 glycine glycine NN cord-010119-t1x9gknd 1116 44 - - HYPH cord-010119-t1x9gknd 1116 45 HCl hcl NN cord-010119-t1x9gknd 1116 46 ( ( -LRB- cord-010119-t1x9gknd 1116 47 20mM 20mm CD cord-010119-t1x9gknd 1116 48 ) ) -RRB- cord-010119-t1x9gknd 1116 49 ; ; : cord-010119-t1x9gknd 1116 50 and and CC cord-010119-t1x9gknd 1116 51 ( ( -LRB- cord-010119-t1x9gknd 1116 52 5 5 LS cord-010119-t1x9gknd 1116 53 ) ) -RRB- cord-010119-t1x9gknd 1116 54 SpDP SpDP VBN cord-010119-t1x9gknd 1116 55 pretreated pretreate VBD cord-010119-t1x9gknd 1116 56 with with IN cord-010119-t1x9gknd 1116 57 glycine glycine NN cord-010119-t1x9gknd 1116 58 - - HYPH cord-010119-t1x9gknd 1116 59 HCl hcl NN cord-010119-t1x9gknd 1116 60 : : : cord-010119-t1x9gknd 1116 61 glycine glycine NN cord-010119-t1x9gknd 1116 62 ( ( -LRB- cord-010119-t1x9gknd 1116 63 20mM:50mM 20mm:50mm CD cord-010119-t1x9gknd 1116 64 ; ; : cord-010119-t1x9gknd 1116 65 both both DT cord-010119-t1x9gknd 1116 66 pretreated pretreate VBN cord-010119-t1x9gknd 1116 67 were be VBD cord-010119-t1x9gknd 1116 68 rehydrated rehydrate VBN cord-010119-t1x9gknd 1116 69 in in IN cord-010119-t1x9gknd 1116 70 water water NN cord-010119-t1x9gknd 1116 71 ) ) -RRB- cord-010119-t1x9gknd 1116 72 . . . cord-010119-t1x9gknd 1117 1 Six six CD cord-010119-t1x9gknd 1117 2 donor donor NN cord-010119-t1x9gknd 1117 3 - - HYPH cord-010119-t1x9gknd 1117 4 matched match VBN cord-010119-t1x9gknd 1117 5 plasmas plasma NNS cord-010119-t1x9gknd 1117 6 of of IN cord-010119-t1x9gknd 1117 7 each each DT cord-010119-t1x9gknd 1117 8 type type NN cord-010119-t1x9gknd 1117 9 were be VBD cord-010119-t1x9gknd 1117 10 tested test VBN cord-010119-t1x9gknd 1117 11 . . . cord-010119-t1x9gknd 1118 1 vWF vwf IN cord-010119-t1x9gknd 1118 2 activity activity NN cord-010119-t1x9gknd 1118 3 was be VBD cord-010119-t1x9gknd 1118 4 measured measure VBN cord-010119-t1x9gknd 1118 5 by by IN cord-010119-t1x9gknd 1118 6 ristocetin ristocetin JJ cord-010119-t1x9gknd 1118 7 cofactor cofactor NN cord-010119-t1x9gknd 1118 8 assay assay NN cord-010119-t1x9gknd 1118 9 . . . cord-010119-t1x9gknd 1119 1 Fibrin fibrin NN cord-010119-t1x9gknd 1119 2 polymerization polymerization NN cord-010119-t1x9gknd 1119 3 kinetics kinetic NNS cord-010119-t1x9gknd 1119 4 were be VBD cord-010119-t1x9gknd 1119 5 analyzed analyze VBN cord-010119-t1x9gknd 1119 6 by by IN cord-010119-t1x9gknd 1119 7 turbidimetry turbidimetry NNP cord-010119-t1x9gknd 1119 8 . . . cord-010119-t1x9gknd 1120 1 Thrombin Thrombin NNP cord-010119-t1x9gknd 1120 2 generation generation NN cord-010119-t1x9gknd 1120 3 ( ( -LRB- cord-010119-t1x9gknd 1120 4 TG TG NNP cord-010119-t1x9gknd 1120 5 ) ) -RRB- cord-010119-t1x9gknd 1120 6 was be VBD cord-010119-t1x9gknd 1120 7 observed observe VBN cord-010119-t1x9gknd 1120 8 by by IN cord-010119-t1x9gknd 1120 9 thrombogram thrombogram NNP cord-010119-t1x9gknd 1120 10 . . . cord-010119-t1x9gknd 1121 1 Chemistry chemistry NN cord-010119-t1x9gknd 1121 2 was be VBD cord-010119-t1x9gknd 1121 3 evaluated evaluate VBN cord-010119-t1x9gknd 1121 4 by by IN cord-010119-t1x9gknd 1121 5 i i NN cord-010119-t1x9gknd 1121 6 - - HYPH cord-010119-t1x9gknd 1121 7 STAT STAT NNP cord-010119-t1x9gknd 1121 8 . . . cord-010119-t1x9gknd 1122 1 Residual residual JJ cord-010119-t1x9gknd 1122 2 cell cell NN cord-010119-t1x9gknd 1122 3 material material NN cord-010119-t1x9gknd 1122 4 was be VBD cord-010119-t1x9gknd 1122 5 quantified quantify VBN cord-010119-t1x9gknd 1122 6 by by IN cord-010119-t1x9gknd 1122 7 flow flow NN cord-010119-t1x9gknd 1122 8 cytometry cytometry NN cord-010119-t1x9gknd 1122 9 . . . cord-010119-t1x9gknd 1123 1 Coagulation coagulation NN cord-010119-t1x9gknd 1123 2 properties property NNS cord-010119-t1x9gknd 1123 3 were be VBD cord-010119-t1x9gknd 1123 4 measured measure VBN cord-010119-t1x9gknd 1123 5 by by IN cord-010119-t1x9gknd 1123 6 thromboelastography thromboelastography NNP cord-010119-t1x9gknd 1123 7 ( ( -LRB- cord-010119-t1x9gknd 1123 8 TEG TEG NNP cord-010119-t1x9gknd 1123 9 ) ) -RRB- cord-010119-t1x9gknd 1123 10 in in IN cord-010119-t1x9gknd 1123 11 plasma plasma NN cord-010119-t1x9gknd 1123 12 and and CC cord-010119-t1x9gknd 1123 13 reconstructed reconstruct VBD cord-010119-t1x9gknd 1123 14 whole whole JJ cord-010119-t1x9gknd 1123 15 blood blood NN cord-010119-t1x9gknd 1123 16 ( ( -LRB- cord-010119-t1x9gknd 1123 17 40 40 CD cord-010119-t1x9gknd 1123 18 % % NN cord-010119-t1x9gknd 1123 19 Hct Hct NNP cord-010119-t1x9gknd 1123 20 with with IN cord-010119-t1x9gknd 1123 21 200 200 CD cord-010119-t1x9gknd 1123 22 platelets platelet NNS cord-010119-t1x9gknd 1123 23 / / SYM cord-010119-t1x9gknd 1123 24 nl nl NNP cord-010119-t1x9gknd 1123 25 from from IN cord-010119-t1x9gknd 1123 26 typematched typematched NNP cord-010119-t1x9gknd 1123 27 donors donor NNS cord-010119-t1x9gknd 1123 28 ) ) -RRB- cord-010119-t1x9gknd 1123 29 . . . cord-010119-t1x9gknd 1124 1 Platelet platelet NN cord-010119-t1x9gknd 1124 2 adhesion adhesion NN cord-010119-t1x9gknd 1124 3 to to IN cord-010119-t1x9gknd 1124 4 collagen collagen NN cord-010119-t1x9gknd 1124 5 under under IN cord-010119-t1x9gknd 1124 6 shear shear NN cord-010119-t1x9gknd 1124 7 was be VBD cord-010119-t1x9gknd 1124 8 measured measure VBN cord-010119-t1x9gknd 1124 9 by by IN cord-010119-t1x9gknd 1124 10 BioFlux BioFlux NNP cord-010119-t1x9gknd 1124 11 . . . cord-010119-t1x9gknd 1125 1 Results/ Results/ . cord-010119-t1x9gknd 1126 1 Finding finding NN cord-010119-t1x9gknd 1126 2 : : : cord-010119-t1x9gknd 1127 1 Pretreated Pretreated NNP cord-010119-t1x9gknd 1127 2 SpDP SpDP NNP cord-010119-t1x9gknd 1127 3 showed show VBD cord-010119-t1x9gknd 1127 4 enhanced enhance VBN cord-010119-t1x9gknd 1127 5 vWF vwf NN cord-010119-t1x9gknd 1127 6 activity activity NN cord-010119-t1x9gknd 1127 7 over over IN cord-010119-t1x9gknd 1127 8 rSpDP rspdp NN cord-010119-t1x9gknd 1127 9 ( ( -LRB- cord-010119-t1x9gknd 1127 10 p p NN cord-010119-t1x9gknd 1127 11 < < XX cord-010119-t1x9gknd 1127 12 .05 .05 NFP cord-010119-t1x9gknd 1127 13 ) ) -RRB- cord-010119-t1x9gknd 1127 14 . . . cord-010119-t1x9gknd 1128 1 Fibrin fibrin NN cord-010119-t1x9gknd 1128 2 polymerization polymerization NN cord-010119-t1x9gknd 1128 3 density density NN cord-010119-t1x9gknd 1128 4 was be VBD cord-010119-t1x9gknd 1128 5 slightly slightly RB cord-010119-t1x9gknd 1128 6 diminished diminish VBN cord-010119-t1x9gknd 1128 7 in in IN cord-010119-t1x9gknd 1128 8 rSpDP rspdp NN cord-010119-t1x9gknd 1128 9 vs. vs. FW cord-010119-t1x9gknd 1128 10 FFP FFP NNP cord-010119-t1x9gknd 1128 11 ( ( -LRB- cord-010119-t1x9gknd 1128 12 0.879 0.879 CD cord-010119-t1x9gknd 1128 13 vs. vs. NN cord-010119-t1x9gknd 1128 14 0.742 0.742 IN cord-010119-t1x9gknd 1128 15 O.D. O.D. NNP cord-010119-t1x9gknd 1128 16 , , , cord-010119-t1x9gknd 1128 17 p p NN cord-010119-t1x9gknd 1128 18 < < XX cord-010119-t1x9gknd 1128 19 .01 .01 NFP cord-010119-t1x9gknd 1128 20 ) ) -RRB- cord-010119-t1x9gknd 1128 21 , , , cord-010119-t1x9gknd 1128 22 but but CC cord-010119-t1x9gknd 1128 23 TG TG NNP cord-010119-t1x9gknd 1128 24 was be VBD cord-010119-t1x9gknd 1128 25 unchanged unchanged JJ cord-010119-t1x9gknd 1128 26 . . . cord-010119-t1x9gknd 1129 1 Bicarbonate bicarbonate NN cord-010119-t1x9gknd 1129 2 / / SYM cord-010119-t1x9gknd 1129 3 base base NN cord-010119-t1x9gknd 1129 4 excess excess NN cord-010119-t1x9gknd 1129 5 were be VBD cord-010119-t1x9gknd 1129 6 lower low JJR cord-010119-t1x9gknd 1129 7 in in IN cord-010119-t1x9gknd 1129 8 SpDP SpDP NNP cord-010119-t1x9gknd 1129 9 samples sample NNS cord-010119-t1x9gknd 1129 10 vs. vs. IN cord-010119-t1x9gknd 1129 11 FFP ffp NN cord-010119-t1x9gknd 1129 12 ( ( -LRB- cord-010119-t1x9gknd 1129 13 p p NN cord-010119-t1x9gknd 1129 14 < < XX cord-010119-t1x9gknd 1129 15 0.001 0.001 CD cord-010119-t1x9gknd 1129 16 ) ) -RRB- cord-010119-t1x9gknd 1129 17 . . . cord-010119-t1x9gknd 1130 1 Residual residual JJ cord-010119-t1x9gknd 1130 2 cellular cellular JJ cord-010119-t1x9gknd 1130 3 material material NN cord-010119-t1x9gknd 1130 4 ( ( -LRB- cord-010119-t1x9gknd 1130 5 especially especially RB cord-010119-t1x9gknd 1130 6 platelet platelet NN cord-010119-t1x9gknd 1130 7 - - HYPH cord-010119-t1x9gknd 1130 8 derived derive VBN cord-010119-t1x9gknd 1130 9 ) ) -RRB- cord-010119-t1x9gknd 1130 10 was be VBD cord-010119-t1x9gknd 1130 11 reduced reduce VBN cord-010119-t1x9gknd 1130 12 threefold threefold RB cord-010119-t1x9gknd 1130 13 in in IN cord-010119-t1x9gknd 1130 14 rSpDP rspdp NN cord-010119-t1x9gknd 1130 15 vs. vs. FW cord-010119-t1x9gknd 1130 16 FFP ffp NN cord-010119-t1x9gknd 1130 17 ( ( -LRB- cord-010119-t1x9gknd 1130 18 p p NN cord-010119-t1x9gknd 1130 19 < < XX cord-010119-t1x9gknd 1130 20 .01 .01 NFP cord-010119-t1x9gknd 1130 21 ) ) -RRB- cord-010119-t1x9gknd 1130 22 and and CC cord-010119-t1x9gknd 1130 23 an an DT cord-010119-t1x9gknd 1130 24 additional additional JJ cord-010119-t1x9gknd 1130 25 twofold twofold NN cord-010119-t1x9gknd 1130 26 in in IN cord-010119-t1x9gknd 1130 27 pretreated pretreate VBN cord-010119-t1x9gknd 1130 28 SpDPs SpDPs NNP cord-010119-t1x9gknd 1130 29 vs. vs. IN cord-010119-t1x9gknd 1130 30 rSpDP rspdp NN cord-010119-t1x9gknd 1130 31 ( ( -LRB- cord-010119-t1x9gknd 1130 32 p p NN cord-010119-t1x9gknd 1130 33 < < XX cord-010119-t1x9gknd 1130 34 .05 .05 NFP cord-010119-t1x9gknd 1130 35 ) ) -RRB- cord-010119-t1x9gknd 1130 36 . . . cord-010119-t1x9gknd 1131 1 TEG TEG NNP cord-010119-t1x9gknd 1131 2 results result NNS cord-010119-t1x9gknd 1131 3 were be VBD cord-010119-t1x9gknd 1131 4 unchanged unchanged JJ cord-010119-t1x9gknd 1131 5 in in IN cord-010119-t1x9gknd 1131 6 plasma plasma NN cord-010119-t1x9gknd 1131 7 - - HYPH cord-010119-t1x9gknd 1131 8 only only JJ cord-010119-t1x9gknd 1131 9 samples sample NNS cord-010119-t1x9gknd 1131 10 ; ; : cord-010119-t1x9gknd 1131 11 in in IN cord-010119-t1x9gknd 1131 12 reconstructed reconstruct VBN cord-010119-t1x9gknd 1131 13 WB WB NNP cord-010119-t1x9gknd 1131 14 there there EX cord-010119-t1x9gknd 1131 15 was be VBD cord-010119-t1x9gknd 1131 16 a a DT cord-010119-t1x9gknd 1131 17 reduction reduction NN cord-010119-t1x9gknd 1131 18 in in IN cord-010119-t1x9gknd 1131 19 amplitude amplitude NN cord-010119-t1x9gknd 1131 20 ( ( -LRB- cord-010119-t1x9gknd 1131 21 clot clot NN cord-010119-t1x9gknd 1131 22 strength strength NN cord-010119-t1x9gknd 1131 23 ) ) -RRB- cord-010119-t1x9gknd 1131 24 in in IN cord-010119-t1x9gknd 1131 25 all all DT cord-010119-t1x9gknd 1131 26 SpDP SpDP NNP cord-010119-t1x9gknd 1131 27 samples sample NNS cord-010119-t1x9gknd 1131 28 vs. vs. FW cord-010119-t1x9gknd 1131 29 ; ; : cord-010119-t1x9gknd 1131 30 p p NN cord-010119-t1x9gknd 1131 31 < < XX cord-010119-t1x9gknd 1131 32 0.01 0.01 CD cord-010119-t1x9gknd 1131 33 ) ) -RRB- cord-010119-t1x9gknd 1131 34 . . . cord-010119-t1x9gknd 1132 1 Platelet platelet NN cord-010119-t1x9gknd 1132 2 adhesion adhesion NN cord-010119-t1x9gknd 1132 3 was be VBD cord-010119-t1x9gknd 1132 4 equivalent equivalent JJ cord-010119-t1x9gknd 1132 5 in in IN cord-010119-t1x9gknd 1132 6 pretreated pretreate VBN cord-010119-t1x9gknd 1132 7 SpDPs SpDPs NNP cord-010119-t1x9gknd 1132 8 and and CC cord-010119-t1x9gknd 1132 9 FFP FFP NNP cord-010119-t1x9gknd 1132 10 , , , cord-010119-t1x9gknd 1132 11 while while IN cord-010119-t1x9gknd 1132 12 rSpDP rspdp NN cord-010119-t1x9gknd 1132 13 was be VBD cord-010119-t1x9gknd 1132 14 improved improve VBN cord-010119-t1x9gknd 1132 15 vs. vs. IN cord-010119-t1x9gknd 1132 16 all all DT cord-010119-t1x9gknd 1132 17 other other JJ cord-010119-t1x9gknd 1132 18 samples sample NNS cord-010119-t1x9gknd 1132 19 ( ( -LRB- cord-010119-t1x9gknd 1132 20 71.53 71.53 CD cord-010119-t1x9gknd 1132 21 % % NN cord-010119-t1x9gknd 1132 22 surface surface NN cord-010119-t1x9gknd 1132 23 coverage coverage NN cord-010119-t1x9gknd 1132 24 vs. vs. CC cord-010119-t1x9gknd 1132 25 30.26 30.26 CD cord-010119-t1x9gknd 1132 26 - - : cord-010119-t1x9gknd 1132 27 43.87 43.87 CD cord-010119-t1x9gknd 1132 28 % % NN cord-010119-t1x9gknd 1132 29 , , , cord-010119-t1x9gknd 1132 30 p p NN cord-010119-t1x9gknd 1132 31 < < XX cord-010119-t1x9gknd 1132 32 .05 .05 NFP cord-010119-t1x9gknd 1132 33 ) ) -RRB- cord-010119-t1x9gknd 1132 34 . . . cord-010119-t1x9gknd 1133 1 Conclusion conclusion NN cord-010119-t1x9gknd 1133 2 : : : cord-010119-t1x9gknd 1134 1 SpDP SpDP NNP cord-010119-t1x9gknd 1134 2 has have VBZ cord-010119-t1x9gknd 1134 3 a a DT cord-010119-t1x9gknd 1134 4 longer long JJR cord-010119-t1x9gknd 1134 5 shelf shelf NN cord-010119-t1x9gknd 1134 6 life life NN cord-010119-t1x9gknd 1134 7 and and CC cord-010119-t1x9gknd 1134 8 easier easy JJR cord-010119-t1x9gknd 1134 9 storage storage NN cord-010119-t1x9gknd 1134 10 requirements requirement NNS cord-010119-t1x9gknd 1134 11 than than IN cord-010119-t1x9gknd 1134 12 FFP FFP NNP cord-010119-t1x9gknd 1134 13 and and CC cord-010119-t1x9gknd 1134 14 was be VBD cord-010119-t1x9gknd 1134 15 equivalent equivalent JJ cord-010119-t1x9gknd 1134 16 or or CC cord-010119-t1x9gknd 1134 17 superior superior JJ cord-010119-t1x9gknd 1134 18 to to IN cord-010119-t1x9gknd 1134 19 FFP FFP NNP cord-010119-t1x9gknd 1134 20 in in IN cord-010119-t1x9gknd 1134 21 most most JJS cord-010119-t1x9gknd 1134 22 of of IN cord-010119-t1x9gknd 1134 23 these these DT cord-010119-t1x9gknd 1134 24 in in IN cord-010119-t1x9gknd 1134 25 vitro vitro FW cord-010119-t1x9gknd 1134 26 assays assay NNS cord-010119-t1x9gknd 1134 27 . . . cord-010119-t1x9gknd 1135 1 SpDP SpDP NNP cord-010119-t1x9gknd 1135 2 pretreated pretreate VBD cord-010119-t1x9gknd 1135 3 with with IN cord-010119-t1x9gknd 1135 4 glycine glycine NN cord-010119-t1x9gknd 1135 5 solutions solution NNS cord-010119-t1x9gknd 1135 6 was be VBD cord-010119-t1x9gknd 1135 7 similar similar JJ cord-010119-t1x9gknd 1135 8 to to IN cord-010119-t1x9gknd 1135 9 FFP FFP NNP cord-010119-t1x9gknd 1135 10 in in IN cord-010119-t1x9gknd 1135 11 most most JJS cord-010119-t1x9gknd 1135 12 assays assay NNS cord-010119-t1x9gknd 1135 13 and and CC cord-010119-t1x9gknd 1135 14 showed show VBD cord-010119-t1x9gknd 1135 15 superior superior JJ cord-010119-t1x9gknd 1135 16 vWF vwf IN cord-010119-t1x9gknd 1135 17 activity activity NN cord-010119-t1x9gknd 1135 18 and and CC cord-010119-t1x9gknd 1135 19 fewer few JJR cord-010119-t1x9gknd 1135 20 residual residual JJ cord-010119-t1x9gknd 1135 21 cellular cellular JJ cord-010119-t1x9gknd 1135 22 materials material NNS cord-010119-t1x9gknd 1135 23 but but CC cord-010119-t1x9gknd 1135 24 inferior inferior JJ cord-010119-t1x9gknd 1135 25 support support NN cord-010119-t1x9gknd 1135 26 for for IN cord-010119-t1x9gknd 1135 27 platelet platelet NN cord-010119-t1x9gknd 1135 28 adhesion adhesion NN cord-010119-t1x9gknd 1135 29 to to IN cord-010119-t1x9gknd 1135 30 collagen collagen NN cord-010119-t1x9gknd 1135 31 while while IN cord-010119-t1x9gknd 1135 32 under under IN cord-010119-t1x9gknd 1135 33 flow flow NN cord-010119-t1x9gknd 1135 34 compared compare VBN cord-010119-t1x9gknd 1135 35 with with IN cord-010119-t1x9gknd 1135 36 untreated untreated JJ cord-010119-t1x9gknd 1135 37 SpDP SpDP NNP cord-010119-t1x9gknd 1135 38 . . . cord-010119-t1x9gknd 1136 1 Clinical clinical JJ cord-010119-t1x9gknd 1136 2 significance significance NN cord-010119-t1x9gknd 1136 3 of of IN cord-010119-t1x9gknd 1136 4 these these DT cord-010119-t1x9gknd 1136 5 findings finding NNS cord-010119-t1x9gknd 1136 6 is be VBZ cord-010119-t1x9gknd 1136 7 unclear unclear JJ cord-010119-t1x9gknd 1136 8 , , , cord-010119-t1x9gknd 1136 9 but but CC cord-010119-t1x9gknd 1136 10 overall overall RB cord-010119-t1x9gknd 1136 11 in in FW cord-010119-t1x9gknd 1136 12 vitro vitro FW cord-010119-t1x9gknd 1136 13 outcomes outcome NNS cord-010119-t1x9gknd 1136 14 suggest suggest VBP cord-010119-t1x9gknd 1136 15 clinical clinical JJ cord-010119-t1x9gknd 1136 16 studies study NNS cord-010119-t1x9gknd 1136 17 are be VBP cord-010119-t1x9gknd 1136 18 warranted warrant VBN cord-010119-t1x9gknd 1136 19 . . . cord-010119-t1x9gknd 1137 1 The the DT cord-010119-t1x9gknd 1137 2 Interaction Interaction NNP cord-010119-t1x9gknd 1137 3 between between IN cord-010119-t1x9gknd 1137 4 Red Red NNP cord-010119-t1x9gknd 1137 5 Blood Blood NNP cord-010119-t1x9gknd 1137 6 Cell Cell NNP cord-010119-t1x9gknd 1137 7 Transfusion Transfusion NNP cord-010119-t1x9gknd 1137 8 and and CC cord-010119-t1x9gknd 1137 9 Lung Lung NNP cord-010119-t1x9gknd 1137 10 Injury injury NN cord-010119-t1x9gknd 1137 11 : : : cord-010119-t1x9gknd 1137 12 The the DT cord-010119-t1x9gknd 1137 13 Influence influence NN cord-010119-t1x9gknd 1137 14 of of IN cord-010119-t1x9gknd 1137 15 Blood Blood NNP cord-010119-t1x9gknd 1137 16 Component Component NNP cord-010119-t1x9gknd 1137 17 Manufacturing Manufacturing NNP cord-010119-t1x9gknd 1137 18 Methods Methods NNPS cord-010119-t1x9gknd 1137 19 Mathijs Mathijs NNP cord-010119-t1x9gknd 1137 20 Wirtz Wirtz NNP cord-010119-t1x9gknd 1137 21 * * NFP cord-010119-t1x9gknd 1137 22 1 1 CD cord-010119-t1x9gknd 1137 23 , , , cord-010119-t1x9gknd 1137 24 Anita Anita NNP cord-010119-t1x9gknd 1137 25 Tuip Tuip NNP cord-010119-t1x9gknd 1137 26 - - HYPH cord-010119-t1x9gknd 1137 27 de de NNP cord-010119-t1x9gknd 1137 28 Boer Boer NNP cord-010119-t1x9gknd 1137 29 1 1 CD cord-010119-t1x9gknd 1137 30 , , , cord-010119-t1x9gknd 1137 31 Ruqayyah Ruqayyah NNP cord-010119-t1x9gknd 1137 32 Almizraq Almizraq NNP cord-010119-t1x9gknd 1137 33 2 2 CD cord-010119-t1x9gknd 1137 34 , , , cord-010119-t1x9gknd 1137 35 Jason Jason NNP cord-010119-t1x9gknd 1137 36 P. P. NNP cord-010119-t1x9gknd 1137 37 Acker Acker NNP cord-010119-t1x9gknd 1137 38 3 3 CD cord-010119-t1x9gknd 1137 39 , , , cord-010119-t1x9gknd 1137 40 Philip Philip NNP cord-010119-t1x9gknd 1137 41 J. J. NNP cord-010119-t1x9gknd 1137 42 Norris Norris NNP cord-010119-t1x9gknd 1137 43 4 4 CD cord-010119-t1x9gknd 1137 44 , , , cord-010119-t1x9gknd 1138 1 Jennifer Jennifer NNP cord-010119-t1x9gknd 1138 2 A A NNP cord-010119-t1x9gknd 1138 3 Muszynski Muszynski NNP cord-010119-t1x9gknd 1138 4 5 5 CD cord-010119-t1x9gknd 1138 5 and and CC cord-010119-t1x9gknd 1138 6 Nicole Nicole NNP cord-010119-t1x9gknd 1138 7 Juffermans Juffermans NNP cord-010119-t1x9gknd 1138 8 1 1 CD cord-010119-t1x9gknd 1138 9 . . . cord-010119-t1x9gknd 1138 10 1 1 CD cord-010119-t1x9gknd 1138 11 Academic Academic NNP cord-010119-t1x9gknd 1138 12 Medical Medical NNP cord-010119-t1x9gknd 1138 13 Center Center NNP cord-010119-t1x9gknd 1138 14 , , , cord-010119-t1x9gknd 1138 15 2 2 CD cord-010119-t1x9gknd 1138 16 University University NNP cord-010119-t1x9gknd 1138 17 of of IN cord-010119-t1x9gknd 1138 18 Alberta Alberta NNP cord-010119-t1x9gknd 1138 19 , , , cord-010119-t1x9gknd 1138 20 3 3 CD cord-010119-t1x9gknd 1138 21 Canadian Canadian NNP cord-010119-t1x9gknd 1138 22 Blood Blood NNP cord-010119-t1x9gknd 1138 23 Services Services NNPS cord-010119-t1x9gknd 1138 24 , , , cord-010119-t1x9gknd 1138 25 4 4 CD cord-010119-t1x9gknd 1138 26 Blood Blood NNP cord-010119-t1x9gknd 1138 27 Systems Systems NNPS cord-010119-t1x9gknd 1138 28 Research Research NNP cord-010119-t1x9gknd 1138 29 Institute Institute NNP cord-010119-t1x9gknd 1138 30 , , , cord-010119-t1x9gknd 1139 1 5 5 CD cord-010119-t1x9gknd 1139 2 Nationwide Nationwide NNP cord-010119-t1x9gknd 1139 3 Children Children NNPS cord-010119-t1x9gknd 1139 4 's 's POS cord-010119-t1x9gknd 1139 5 Hospital Hospital NNP cord-010119-t1x9gknd 1139 6 Background Background NNP cord-010119-t1x9gknd 1139 7 / / SYM cord-010119-t1x9gknd 1139 8 Case Case NNP cord-010119-t1x9gknd 1139 9 Studies Studies NNPS cord-010119-t1x9gknd 1139 10 : : : cord-010119-t1x9gknd 1139 11 Red red JJ cord-010119-t1x9gknd 1139 12 blood blood NN cord-010119-t1x9gknd 1139 13 cell cell NN cord-010119-t1x9gknd 1139 14 ( ( -LRB- cord-010119-t1x9gknd 1139 15 RBC RBC NNP cord-010119-t1x9gknd 1139 16 ) ) -RRB- cord-010119-t1x9gknd 1139 17 transfusion transfusion NN cord-010119-t1x9gknd 1139 18 is be VBZ cord-010119-t1x9gknd 1139 19 associated associate VBN cord-010119-t1x9gknd 1139 20 with with IN cord-010119-t1x9gknd 1139 21 acute acute JJ cord-010119-t1x9gknd 1139 22 lung lung NN cord-010119-t1x9gknd 1139 23 injury injury NN cord-010119-t1x9gknd 1139 24 , , , cord-010119-t1x9gknd 1139 25 in in IN cord-010119-t1x9gknd 1139 26 particular particular JJ cord-010119-t1x9gknd 1139 27 in in IN cord-010119-t1x9gknd 1139 28 patients patient NNS cord-010119-t1x9gknd 1139 29 on on IN cord-010119-t1x9gknd 1139 30 mechanical mechanical JJ cord-010119-t1x9gknd 1139 31 ventilation ventilation NN cord-010119-t1x9gknd 1139 32 . . . cord-010119-t1x9gknd 1140 1 The the DT cord-010119-t1x9gknd 1140 2 causative causative JJ cord-010119-t1x9gknd 1140 3 factor factor NN cord-010119-t1x9gknd 1140 4 is be VBZ cord-010119-t1x9gknd 1140 5 not not RB cord-010119-t1x9gknd 1140 6 known know VBN cord-010119-t1x9gknd 1140 7 but but CC cord-010119-t1x9gknd 1140 8 may may MD cord-010119-t1x9gknd 1140 9 include include VB cord-010119-t1x9gknd 1140 10 residual residual JJ cord-010119-t1x9gknd 1140 11 cells cell NNS cord-010119-t1x9gknd 1140 12 or or CC cord-010119-t1x9gknd 1140 13 extracellular extracellular JJ cord-010119-t1x9gknd 1140 14 vesicles vesicle NNS cord-010119-t1x9gknd 1140 15 ( ( -LRB- cord-010119-t1x9gknd 1140 16 EVs ev NNS cord-010119-t1x9gknd 1140 17 ) ) -RRB- cord-010119-t1x9gknd 1140 18 . . . cord-010119-t1x9gknd 1141 1 In in IN cord-010119-t1x9gknd 1141 2 this this DT cord-010119-t1x9gknd 1141 3 study study NN cord-010119-t1x9gknd 1141 4 we -PRON- PRP cord-010119-t1x9gknd 1141 5 investigated investigate VBD cord-010119-t1x9gknd 1141 6 the the DT cord-010119-t1x9gknd 1141 7 functional functional JJ cord-010119-t1x9gknd 1141 8 effect effect NN cord-010119-t1x9gknd 1141 9 of of IN cord-010119-t1x9gknd 1141 10 different different JJ cord-010119-t1x9gknd 1141 11 manufacturing manufacturing NN cord-010119-t1x9gknd 1141 12 methods method NNS cord-010119-t1x9gknd 1141 13 of of IN cord-010119-t1x9gknd 1141 14 RBC RBC NNP cord-010119-t1x9gknd 1141 15 products product NNS cord-010119-t1x9gknd 1141 16 on on IN cord-010119-t1x9gknd 1141 17 the the DT cord-010119-t1x9gknd 1141 18 response response NN cord-010119-t1x9gknd 1141 19 of of IN cord-010119-t1x9gknd 1141 20 pulmonary pulmonary JJ cord-010119-t1x9gknd 1141 21 cells cell NNS cord-010119-t1x9gknd 1141 22 in in IN cord-010119-t1x9gknd 1141 23 an an DT cord-010119-t1x9gknd 1141 24 in in FW cord-010119-t1x9gknd 1141 25 vitro vitro FW cord-010119-t1x9gknd 1141 26 model model NN cord-010119-t1x9gknd 1141 27 of of IN cord-010119-t1x9gknd 1141 28 mechanical mechanical JJ cord-010119-t1x9gknd 1141 29 ventilation ventilation NN cord-010119-t1x9gknd 1141 30 . . . cord-010119-t1x9gknd 1142 1 Study Study NNP cord-010119-t1x9gknd 1142 2 Design Design NNP cord-010119-t1x9gknd 1142 3 / / SYM cord-010119-t1x9gknd 1142 4 Methods method NNS cord-010119-t1x9gknd 1142 5 : : : cord-010119-t1x9gknd 1142 6 Groups Groups NNPS cord-010119-t1x9gknd 1142 7 of of IN cord-010119-t1x9gknd 1142 8 RBC RBC NNP cord-010119-t1x9gknd 1142 9 products product NNS cord-010119-t1x9gknd 1142 10 ( ( -LRB- cord-010119-t1x9gknd 1142 11 whole whole JJ cord-010119-t1x9gknd 1142 12 blood blood NN cord-010119-t1x9gknd 1142 13 filtered filter VBD cord-010119-t1x9gknd 1142 14 [ [ -LRB- cord-010119-t1x9gknd 1142 15 WBF WBF NNP cord-010119-t1x9gknd 1142 16 ] ] -RRB- cord-010119-t1x9gknd 1142 17 , , , cord-010119-t1x9gknd 1142 18 red red JJ cord-010119-t1x9gknd 1142 19 cell cell NN cord-010119-t1x9gknd 1142 20 filtered filter VBN cord-010119-t1x9gknd 1142 21 [ [ -LRB- cord-010119-t1x9gknd 1142 22 RCF RCF NNP cord-010119-t1x9gknd 1142 23 ] ] -RRB- cord-010119-t1x9gknd 1142 24 , , , cord-010119-t1x9gknd 1142 25 apheresis apheresis NN cord-010119-t1x9gknd 1142 26 derived derive VBD cord-010119-t1x9gknd 1142 27 [ [ -LRB- cord-010119-t1x9gknd 1142 28 AD ad NN cord-010119-t1x9gknd 1142 29 ] ] -RRB- cord-010119-t1x9gknd 1142 30 and and CC cord-010119-t1x9gknd 1142 31 whole whole JJ cord-010119-t1x9gknd 1142 32 blood blood NN cord-010119-t1x9gknd 1142 33 derived derive VBN cord-010119-t1x9gknd 1142 34 [ [ -LRB- cord-010119-t1x9gknd 1142 35 WBD WBD NNP cord-010119-t1x9gknd 1142 36 ] ] -RRB- cord-010119-t1x9gknd 1142 37 ) ) -RRB- cord-010119-t1x9gknd 1142 38 were be VBD cord-010119-t1x9gknd 1142 39 manufactured manufacture VBN cord-010119-t1x9gknd 1142 40 from from IN cord-010119-t1x9gknd 1142 41 8 8 CD cord-010119-t1x9gknd 1142 42 donors donor NNS cord-010119-t1x9gknd 1142 43 ( ( -LRB- cord-010119-t1x9gknd 1142 44 blood blood NN cord-010119-t1x9gknd 1142 45 type type NN cord-010119-t1x9gknd 1142 46 A a NN cord-010119-t1x9gknd 1142 47 or or CC cord-010119-t1x9gknd 1142 48 B b NN cord-010119-t1x9gknd 1142 49 ) ) -RRB- cord-010119-t1x9gknd 1142 50 . . . cord-010119-t1x9gknd 1143 1 Supernatants supernatant NNS cord-010119-t1x9gknd 1143 2 were be VBD cord-010119-t1x9gknd 1143 3 prepared prepare VBN cord-010119-t1x9gknd 1143 4 after after IN cord-010119-t1x9gknd 1143 5 4 4 CD cord-010119-t1x9gknd 1143 6 - - SYM cord-010119-t1x9gknd 1143 7 5 5 CD cord-010119-t1x9gknd 1143 8 ( ( -LRB- cord-010119-t1x9gknd 1143 9 fresh fresh JJ cord-010119-t1x9gknd 1143 10 ) ) -RRB- cord-010119-t1x9gknd 1143 11 and and CC cord-010119-t1x9gknd 1143 12 41 41 CD cord-010119-t1x9gknd 1143 13 - - SYM cord-010119-t1x9gknd 1143 14 42 42 CD cord-010119-t1x9gknd 1143 15 days day NNS cord-010119-t1x9gknd 1143 16 of of IN cord-010119-t1x9gknd 1143 17 storage storage NN cord-010119-t1x9gknd 1143 18 ( ( -LRB- cord-010119-t1x9gknd 1143 19 stored store VBN cord-010119-t1x9gknd 1143 20 ) ) -RRB- cord-010119-t1x9gknd 1143 21 for for IN cord-010119-t1x9gknd 1143 22 measurement measurement NN cord-010119-t1x9gknd 1143 23 of of IN cord-010119-t1x9gknd 1143 24 thrombin thrombin JJ cord-010119-t1x9gknd 1143 25 generation generation NN cord-010119-t1x9gknd 1143 26 and and CC cord-010119-t1x9gknd 1143 27 EV ev NN cord-010119-t1x9gknd 1143 28 analysis analysis NN cord-010119-t1x9gknd 1143 29 . . . cord-010119-t1x9gknd 1144 1 A549 a549 JJ cord-010119-t1x9gknd 1144 2 type type NN cord-010119-t1x9gknd 1144 3 II ii CD cord-010119-t1x9gknd 1144 4 alveolar alveolar NN cord-010119-t1x9gknd 1144 5 cells cell NNS cord-010119-t1x9gknd 1144 6 were be VBD cord-010119-t1x9gknd 1144 7 seeded seed VBN cord-010119-t1x9gknd 1144 8 onto onto IN cord-010119-t1x9gknd 1144 9 flexible flexible JJ cord-010119-t1x9gknd 1144 10 membranes membrane NNS cord-010119-t1x9gknd 1144 11 and and CC cord-010119-t1x9gknd 1144 12 incubated incubate VBN cord-010119-t1x9gknd 1144 13 with with IN cord-010119-t1x9gknd 1144 14 RBC RBC NNP cord-010119-t1x9gknd 1144 15 supernatant supernatant JJ cord-010119-t1x9gknd 1144 16 . . . cord-010119-t1x9gknd 1145 1 Cells cell NNS cord-010119-t1x9gknd 1145 2 were be VBD cord-010119-t1x9gknd 1145 3 subjected subject VBN cord-010119-t1x9gknd 1145 4 to to IN cord-010119-t1x9gknd 1145 5 25 25 CD cord-010119-t1x9gknd 1145 6 % % NN cord-010119-t1x9gknd 1145 7 stretch stretch NN cord-010119-t1x9gknd 1145 8 using use VBG cord-010119-t1x9gknd 1145 9 a a DT cord-010119-t1x9gknd 1145 10 cellstretcher cellstretcher NN cord-010119-t1x9gknd 1145 11 . . . cord-010119-t1x9gknd 1146 1 Control control NN cord-010119-t1x9gknd 1146 2 cells cell NNS cord-010119-t1x9gknd 1146 3 were be VBD cord-010119-t1x9gknd 1146 4 not not RB cord-010119-t1x9gknd 1146 5 stretched stretch VBN cord-010119-t1x9gknd 1146 6 . . . cord-010119-t1x9gknd 1147 1 After after IN cord-010119-t1x9gknd 1147 2 24 24 CD cord-010119-t1x9gknd 1147 3 hours hour NNS cord-010119-t1x9gknd 1147 4 , , , cord-010119-t1x9gknd 1147 5 IL-8 IL-8 NNP cord-010119-t1x9gknd 1147 6 and and CC cord-010119-t1x9gknd 1147 7 IL-6 IL-6 NNP cord-010119-t1x9gknd 1147 8 production production NN cord-010119-t1x9gknd 1147 9 were be VBD cord-010119-t1x9gknd 1147 10 measured measure VBN cord-010119-t1x9gknd 1147 11 . . . cord-010119-t1x9gknd 1148 1 Results result NNS cord-010119-t1x9gknd 1148 2 / / SYM cord-010119-t1x9gknd 1148 3 Findings finding NNS cord-010119-t1x9gknd 1148 4 : : : cord-010119-t1x9gknd 1149 1 Both both CC cord-010119-t1x9gknd 1149 2 fresh fresh JJ cord-010119-t1x9gknd 1149 3 and and CC cord-010119-t1x9gknd 1149 4 stored store VBD cord-010119-t1x9gknd 1149 5 supernatants supernatant NNS cord-010119-t1x9gknd 1149 6 from from IN cord-010119-t1x9gknd 1149 7 AD ad NN cord-010119-t1x9gknd 1149 8 products product NNS cord-010119-t1x9gknd 1149 9 significantly significantly RB cord-010119-t1x9gknd 1149 10 increased increase VBD cord-010119-t1x9gknd 1149 11 pulmonary pulmonary JJ cord-010119-t1x9gknd 1149 12 cell cell NN cord-010119-t1x9gknd 1149 13 IL-6 IL-6 NNP cord-010119-t1x9gknd 1149 14 and and CC cord-010119-t1x9gknd 1149 15 IL-8 IL-8 NNP cord-010119-t1x9gknd 1149 16 production production NN cord-010119-t1x9gknd 1149 17 compared compare VBN cord-010119-t1x9gknd 1149 18 to to IN cord-010119-t1x9gknd 1149 19 incubation incubation NN cord-010119-t1x9gknd 1149 20 with with IN cord-010119-t1x9gknd 1149 21 other other JJ cord-010119-t1x9gknd 1149 22 RBC RBC NNP cord-010119-t1x9gknd 1149 23 products product NNS cord-010119-t1x9gknd 1149 24 and and CC cord-010119-t1x9gknd 1149 25 non non JJ cord-010119-t1x9gknd 1149 26 - - JJ cord-010119-t1x9gknd 1149 27 incubated incubate VBN cord-010119-t1x9gknd 1149 28 controls control NNS cord-010119-t1x9gknd 1149 29 , , , cord-010119-t1x9gknd 1149 30 which which WDT cord-010119-t1x9gknd 1149 31 was be VBD cord-010119-t1x9gknd 1149 32 further further RB cord-010119-t1x9gknd 1149 33 exacerbated exacerbate VBN cord-010119-t1x9gknd 1149 34 by by IN cord-010119-t1x9gknd 1149 35 cell cell NN cord-010119-t1x9gknd 1149 36 stretching stretching NN cord-010119-t1x9gknd 1149 37 . . . cord-010119-t1x9gknd 1150 1 AD ad NN cord-010119-t1x9gknd 1150 2 products product NNS cord-010119-t1x9gknd 1150 3 also also RB cord-010119-t1x9gknd 1150 4 had have VBD cord-010119-t1x9gknd 1150 5 significantly significantly RB cord-010119-t1x9gknd 1150 6 increased increase VBN cord-010119-t1x9gknd 1150 7 thrombin thrombin NN cord-010119-t1x9gknd 1150 8 generating generate VBG cord-010119-t1x9gknd 1150 9 ability ability NN cord-010119-t1x9gknd 1150 10 compared compare VBN cord-010119-t1x9gknd 1150 11 to to IN cord-010119-t1x9gknd 1150 12 other other JJ cord-010119-t1x9gknd 1150 13 RBC RBC NNP cord-010119-t1x9gknd 1150 14 products product NNS cord-010119-t1x9gknd 1150 15 , , , cord-010119-t1x9gknd 1150 16 as as RB cord-010119-t1x9gknd 1150 17 well well RB cord-010119-t1x9gknd 1150 18 as as IN cord-010119-t1x9gknd 1150 19 a a DT cord-010119-t1x9gknd 1150 20 significantly significantly RB cord-010119-t1x9gknd 1150 21 increased increase VBN cord-010119-t1x9gknd 1150 22 number number NN cord-010119-t1x9gknd 1150 23 of of IN cord-010119-t1x9gknd 1150 24 RBC RBC NNP cord-010119-t1x9gknd 1150 25 - - HYPH cord-010119-t1x9gknd 1150 26 derived derive VBN cord-010119-t1x9gknd 1150 27 EVs ev NNS cord-010119-t1x9gknd 1150 28 compared compare VBN cord-010119-t1x9gknd 1150 29 to to IN cord-010119-t1x9gknd 1150 30 RCF RCF NNP cord-010119-t1x9gknd 1150 31 and and CC cord-010119-t1x9gknd 1150 32 WBD WBD NNP cord-010119-t1x9gknd 1150 33 products product NNS cord-010119-t1x9gknd 1150 34 ( ( -LRB- cord-010119-t1x9gknd 1150 35 p<0.05 p<0.05 CD cord-010119-t1x9gknd 1150 36 ) ) -RRB- cord-010119-t1x9gknd 1150 37 . . . cord-010119-t1x9gknd 1151 1 Incubation incubation NN cord-010119-t1x9gknd 1151 2 of of IN cord-010119-t1x9gknd 1151 3 stretched stretched JJ cord-010119-t1x9gknd 1151 4 cells cell NNS cord-010119-t1x9gknd 1151 5 with with IN cord-010119-t1x9gknd 1151 6 stored store VBN cord-010119-t1x9gknd 1151 7 WBF WBF NNP cord-010119-t1x9gknd 1151 8 products product NNS cord-010119-t1x9gknd 1151 9 resulted result VBD cord-010119-t1x9gknd 1151 10 in in IN cord-010119-t1x9gknd 1151 11 higher high JJR cord-010119-t1x9gknd 1151 12 IL-8 il-8 NN cord-010119-t1x9gknd 1151 13 production production NN cord-010119-t1x9gknd 1151 14 compared compare VBN cord-010119-t1x9gknd 1151 15 to to IN cord-010119-t1x9gknd 1151 16 other other JJ cord-010119-t1x9gknd 1151 17 blood blood NN cord-010119-t1x9gknd 1151 18 products product NNS cord-010119-t1x9gknd 1151 19 and and CC cord-010119-t1x9gknd 1151 20 stretched stretch VBN cord-010119-t1x9gknd 1151 21 controls control NNS cord-010119-t1x9gknd 1151 22 . . . cord-010119-t1x9gknd 1152 1 RCF RCF NNP cord-010119-t1x9gknd 1152 2 products product NNS cord-010119-t1x9gknd 1152 3 did do VBD cord-010119-t1x9gknd 1152 4 not not RB cord-010119-t1x9gknd 1152 5 activate activate VB cord-010119-t1x9gknd 1152 6 pulmonary pulmonary JJ cord-010119-t1x9gknd 1152 7 cells cell NNS cord-010119-t1x9gknd 1152 8 , , , cord-010119-t1x9gknd 1152 9 had have VBD cord-010119-t1x9gknd 1152 10 an an DT cord-010119-t1x9gknd 1152 11 absence absence NN cord-010119-t1x9gknd 1152 12 of of IN cord-010119-t1x9gknd 1152 13 TG TG NNP cord-010119-t1x9gknd 1152 14 and and CC cord-010119-t1x9gknd 1152 15 had have VBD cord-010119-t1x9gknd 1152 16 low low JJ cord-010119-t1x9gknd 1152 17 levels level NNS cord-010119-t1x9gknd 1152 18 of of IN cord-010119-t1x9gknd 1152 19 EVs ev NNS cord-010119-t1x9gknd 1152 20 compared compare VBN cord-010119-t1x9gknd 1152 21 to to IN cord-010119-t1x9gknd 1152 22 other other JJ cord-010119-t1x9gknd 1152 23 products product NNS cord-010119-t1x9gknd 1152 24 . . . cord-010119-t1x9gknd 1153 1 Conclusion conclusion NN cord-010119-t1x9gknd 1153 2 : : : cord-010119-t1x9gknd 1154 1 Manufacturing manufacturing NN cord-010119-t1x9gknd 1154 2 methods method NNS cord-010119-t1x9gknd 1154 3 markedly markedly RB cord-010119-t1x9gknd 1154 4 influence influence VBP cord-010119-t1x9gknd 1154 5 the the DT cord-010119-t1x9gknd 1154 6 interaction interaction NN cord-010119-t1x9gknd 1154 7 of of IN cord-010119-t1x9gknd 1154 8 RBC RBC NNP cord-010119-t1x9gknd 1154 9 products product NNS cord-010119-t1x9gknd 1154 10 with with IN cord-010119-t1x9gknd 1154 11 lung lung NN cord-010119-t1x9gknd 1154 12 cells cell NNS cord-010119-t1x9gknd 1154 13 . . . cord-010119-t1x9gknd 1155 1 AD ad NN cord-010119-t1x9gknd 1155 2 products product NNS cord-010119-t1x9gknd 1155 3 activate activate VBP cord-010119-t1x9gknd 1155 4 lung lung NN cord-010119-t1x9gknd 1155 5 cells cell NNS cord-010119-t1x9gknd 1155 6 , , , cord-010119-t1x9gknd 1155 7 which which WDT cord-010119-t1x9gknd 1155 8 is be VBZ cord-010119-t1x9gknd 1155 9 further far RBR cord-010119-t1x9gknd 1155 10 aggravated aggravate VBN cord-010119-t1x9gknd 1155 11 by by IN cord-010119-t1x9gknd 1155 12 cell cell NN cord-010119-t1x9gknd 1155 13 stretching stretching NN cord-010119-t1x9gknd 1155 14 . . . cord-010119-t1x9gknd 1156 1 This this DT cord-010119-t1x9gknd 1156 2 may may MD cord-010119-t1x9gknd 1156 3 in in IN cord-010119-t1x9gknd 1156 4 part part NN cord-010119-t1x9gknd 1156 5 be be VB cord-010119-t1x9gknd 1156 6 mediated mediate VBN cord-010119-t1x9gknd 1156 7 by by IN cord-010119-t1x9gknd 1156 8 RBC RBC NNP cord-010119-t1x9gknd 1156 9 - - HYPH cord-010119-t1x9gknd 1156 10 Background Background NNP cord-010119-t1x9gknd 1156 11 / / SYM cord-010119-t1x9gknd 1156 12 Case Case NNP cord-010119-t1x9gknd 1156 13 Studies Studies NNPS cord-010119-t1x9gknd 1156 14 : : : cord-010119-t1x9gknd 1156 15 Investigators investigator NNS cord-010119-t1x9gknd 1156 16 previously previously RB cord-010119-t1x9gknd 1156 17 demonstrated demonstrate VBD cord-010119-t1x9gknd 1156 18 immunosuppressive immunosuppressive JJ cord-010119-t1x9gknd 1156 19 effects effect NNS cord-010119-t1x9gknd 1156 20 of of IN cord-010119-t1x9gknd 1156 21 RBC RBC NNP cord-010119-t1x9gknd 1156 22 supernatant supernatant JJ cord-010119-t1x9gknd 1156 23 on on IN cord-010119-t1x9gknd 1156 24 monocytes monocyte NNS cord-010119-t1x9gknd 1156 25 in in IN cord-010119-t1x9gknd 1156 26 vitro vitro FW cord-010119-t1x9gknd 1156 27 , , , cord-010119-t1x9gknd 1156 28 with with IN cord-010119-t1x9gknd 1156 29 greater great JJR cord-010119-t1x9gknd 1156 30 effects effect NNS cord-010119-t1x9gknd 1156 31 seen see VBN cord-010119-t1x9gknd 1156 32 in in IN cord-010119-t1x9gknd 1156 33 response response NN cord-010119-t1x9gknd 1156 34 to to IN cord-010119-t1x9gknd 1156 35 older old JJR cord-010119-t1x9gknd 1156 36 units unit NNS cord-010119-t1x9gknd 1156 37 . . . cord-010119-t1x9gknd 1157 1 Recent recent JJ cord-010119-t1x9gknd 1157 2 clinical clinical JJ cord-010119-t1x9gknd 1157 3 data datum NNS cord-010119-t1x9gknd 1157 4 suggest suggest VBP cord-010119-t1x9gknd 1157 5 that that IN cord-010119-t1x9gknd 1157 6 RBC RBC NNP cord-010119-t1x9gknd 1157 7 manufacturing manufacturing NN cord-010119-t1x9gknd 1157 8 method method NN cord-010119-t1x9gknd 1157 9 may may MD cord-010119-t1x9gknd 1157 10 influence influence VB cord-010119-t1x9gknd 1157 11 immunomodulatory immunomodulatory JJ cord-010119-t1x9gknd 1157 12 potential potential NN cord-010119-t1x9gknd 1157 13 , , , cord-010119-t1x9gknd 1157 14 but but CC cord-010119-t1x9gknd 1157 15 this this DT cord-010119-t1x9gknd 1157 16 has have VBZ cord-010119-t1x9gknd 1157 17 not not RB cord-010119-t1x9gknd 1157 18 been be VBN cord-010119-t1x9gknd 1157 19 directly directly RB cord-010119-t1x9gknd 1157 20 measured measure VBN cord-010119-t1x9gknd 1157 21 . . . cord-010119-t1x9gknd 1158 1 We -PRON- PRP cord-010119-t1x9gknd 1158 2 used use VBD cord-010119-t1x9gknd 1158 3 in in IN cord-010119-t1x9gknd 1158 4 vitro vitro FW cord-010119-t1x9gknd 1158 5 models model NNS cord-010119-t1x9gknd 1158 6 to to TO cord-010119-t1x9gknd 1158 7 test test VB cord-010119-t1x9gknd 1158 8 the the DT cord-010119-t1x9gknd 1158 9 hypothesis hypothesis NN cord-010119-t1x9gknd 1158 10 that that IN cord-010119-t1x9gknd 1158 11 RBC RBC NNP cord-010119-t1x9gknd 1158 12 supernatants supernatant NNS cord-010119-t1x9gknd 1158 13 obtained obtain VBN cord-010119-t1x9gknd 1158 14 by by IN cord-010119-t1x9gknd 1158 15 different different JJ cord-010119-t1x9gknd 1158 16 manufacturing manufacturing NN cord-010119-t1x9gknd 1158 17 methods method NNS cord-010119-t1x9gknd 1158 18 will will MD cord-010119-t1x9gknd 1158 19 have have VB cord-010119-t1x9gknd 1158 20 differential differential JJ cord-010119-t1x9gknd 1158 21 effects effect NNS cord-010119-t1x9gknd 1158 22 on on IN cord-010119-t1x9gknd 1158 23 monocyte monocyte NNP cord-010119-t1x9gknd 1158 24 function function NN cord-010119-t1x9gknd 1158 25 . . . cord-010119-t1x9gknd 1159 1 Study Study NNP cord-010119-t1x9gknd 1159 2 Design Design NNP cord-010119-t1x9gknd 1159 3 / / SYM cord-010119-t1x9gknd 1159 4 Method method NN cord-010119-t1x9gknd 1159 5 : : : cord-010119-t1x9gknd 1159 6 RBC RBC NNP cord-010119-t1x9gknd 1159 7 products product NNS cord-010119-t1x9gknd 1159 8 were be VBD cord-010119-t1x9gknd 1159 9 manufactured manufacture VBN cord-010119-t1x9gknd 1159 10 by by IN cord-010119-t1x9gknd 1159 11 4 4 CD cord-010119-t1x9gknd 1159 12 different different JJ cord-010119-t1x9gknd 1159 13 methods method NNS cord-010119-t1x9gknd 1159 14 from from IN cord-010119-t1x9gknd 1159 15 5 5 CD cord-010119-t1x9gknd 1159 16 individual individual JJ cord-010119-t1x9gknd 1159 17 donors donor NNS cord-010119-t1x9gknd 1159 18 , , , cord-010119-t1x9gknd 1159 19 each each DT cord-010119-t1x9gknd 1159 20 : : : cord-010119-t1x9gknd 1159 21 ( ( -LRB- cord-010119-t1x9gknd 1159 22 whole whole JJ cord-010119-t1x9gknd 1159 23 blood blood NN cord-010119-t1x9gknd 1159 24 filtration filtration NN cord-010119-t1x9gknd 1159 25 [ [ -LRB- cord-010119-t1x9gknd 1159 26 WBF WBF NNP cord-010119-t1x9gknd 1159 27 ] ] -RRB- cord-010119-t1x9gknd 1159 28 , , , cord-010119-t1x9gknd 1159 29 red red JJ cord-010119-t1x9gknd 1159 30 cell cell NN cord-010119-t1x9gknd 1159 31 filtration filtration NN cord-010119-t1x9gknd 1159 32 [ [ -LRB- cord-010119-t1x9gknd 1159 33 RCF RCF NNP cord-010119-t1x9gknd 1159 34 ] ] -RRB- cord-010119-t1x9gknd 1159 35 , , , cord-010119-t1x9gknd 1159 36 apheresis apheresis NN cord-010119-t1x9gknd 1159 37 , , , cord-010119-t1x9gknd 1159 38 and and CC cord-010119-t1x9gknd 1159 39 whole whole JJ cord-010119-t1x9gknd 1159 40 blood blood NN cord-010119-t1x9gknd 1159 41 derived derive VBN cord-010119-t1x9gknd 1159 42 [ [ -LRB- cord-010119-t1x9gknd 1159 43 WBD WBD NNP cord-010119-t1x9gknd 1159 44 ] ] -RRB- cord-010119-t1x9gknd 1159 45 ) ) -RRB- cord-010119-t1x9gknd 1159 46 . . . cord-010119-t1x9gknd 1160 1 RBC RBC NNP cord-010119-t1x9gknd 1160 2 products product NNS cord-010119-t1x9gknd 1160 3 were be VBD cord-010119-t1x9gknd 1160 4 stored store VBN cord-010119-t1x9gknd 1160 5 in in IN cord-010119-t1x9gknd 1160 6 SAGM SAGM NNP cord-010119-t1x9gknd 1160 7 ( ( -LRB- cord-010119-t1x9gknd 1160 8 WBF WBF NNP cord-010119-t1x9gknd 1160 9 and and CC cord-010119-t1x9gknd 1160 10 RCF RCF NNP cord-010119-t1x9gknd 1160 11 ) ) -RRB- cord-010119-t1x9gknd 1160 12 or or CC cord-010119-t1x9gknd 1160 13 ADSOL ADSOL NNP cord-010119-t1x9gknd 1160 14 - - HYPH cord-010119-t1x9gknd 1160 15 containing contain VBG cord-010119-t1x9gknd 1160 16 preservative preservative NN cord-010119-t1x9gknd 1160 17 solution solution NN cord-010119-t1x9gknd 1160 18 ( ( -LRB- cord-010119-t1x9gknd 1160 19 apheresis apheresis NN cord-010119-t1x9gknd 1160 20 and and CC cord-010119-t1x9gknd 1160 21 WBD WBD NNP cord-010119-t1x9gknd 1160 22 ) ) -RRB- cord-010119-t1x9gknd 1160 23 . . . cord-010119-t1x9gknd 1161 1 Supernatants supernatant NNS cord-010119-t1x9gknd 1161 2 were be VBD cord-010119-t1x9gknd 1161 3 obtained obtain VBN cord-010119-t1x9gknd 1161 4 after after IN cord-010119-t1x9gknd 1161 5 4 4 CD cord-010119-t1x9gknd 1161 6 - - SYM cord-010119-t1x9gknd 1161 7 5 5 CD cord-010119-t1x9gknd 1161 8 days day NNS cord-010119-t1x9gknd 1161 9 ( ( -LRB- cord-010119-t1x9gknd 1161 10 fresh fresh JJ cord-010119-t1x9gknd 1161 11 ) ) -RRB- cord-010119-t1x9gknd 1161 12 and and CC cord-010119-t1x9gknd 1161 13 41 41 CD cord-010119-t1x9gknd 1161 14 - - SYM cord-010119-t1x9gknd 1161 15 42 42 CD cord-010119-t1x9gknd 1161 16 days day NNS cord-010119-t1x9gknd 1161 17 ( ( -LRB- cord-010119-t1x9gknd 1161 18 expiry expiry NN cord-010119-t1x9gknd 1161 19 ) ) -RRB- cord-010119-t1x9gknd 1161 20 . . . cord-010119-t1x9gknd 1162 1 Monocytes monocyte NNS cord-010119-t1x9gknd 1162 2 were be VBD cord-010119-t1x9gknd 1162 3 co co JJ cord-010119-t1x9gknd 1162 4 - - JJ cord-010119-t1x9gknd 1162 5 cultured cultured JJ cord-010119-t1x9gknd 1162 6 in in IN cord-010119-t1x9gknd 1162 7 media medium NNS cord-010119-t1x9gknd 1162 8 plus plus CC cord-010119-t1x9gknd 1162 9 20 20 CD cord-010119-t1x9gknd 1162 10 % % NN cord-010119-t1x9gknd 1162 11 RBC RBC NNP cord-010119-t1x9gknd 1162 12 supernatant supernatant NN cord-010119-t1x9gknd 1162 13 or or CC cord-010119-t1x9gknd 1162 14 media medium NNS cord-010119-t1x9gknd 1162 15 only only RB cord-010119-t1x9gknd 1162 16 ( ( -LRB- cord-010119-t1x9gknd 1162 17 control control NN cord-010119-t1x9gknd 1162 18 ) ) -RRB- cord-010119-t1x9gknd 1162 19 followed follow VBN cord-010119-t1x9gknd 1162 20 by by IN cord-010119-t1x9gknd 1162 21 LPS LPS NNP cord-010119-t1x9gknd 1162 22 stimulation stimulation NN cord-010119-t1x9gknd 1162 23 . . . cord-010119-t1x9gknd 1163 1 Experiments experiment NNS cord-010119-t1x9gknd 1163 2 were be VBD cord-010119-t1x9gknd 1163 3 performed perform VBN cord-010119-t1x9gknd 1163 4 in in IN cord-010119-t1x9gknd 1163 5 5 5 CD cord-010119-t1x9gknd 1163 6 replicates replicate NNS cord-010119-t1x9gknd 1163 7 , , , cord-010119-t1x9gknd 1163 8 each each DT cord-010119-t1x9gknd 1163 9 with with IN cord-010119-t1x9gknd 1163 10 a a DT cord-010119-t1x9gknd 1163 11 distinct distinct JJ cord-010119-t1x9gknd 1163 12 monocyte monocyte JJ cord-010119-t1x9gknd 1163 13 donor donor NN cord-010119-t1x9gknd 1163 14 . . . cord-010119-t1x9gknd 1164 1 Comparisons comparison NNS cord-010119-t1x9gknd 1164 2 between between IN cord-010119-t1x9gknd 1164 3 groups group NNS cord-010119-t1x9gknd 1164 4 by by IN cord-010119-t1x9gknd 1164 5 ANOVA ANOVA NNP cord-010119-t1x9gknd 1164 6 with with IN cord-010119-t1x9gknd 1164 7 Dunnett Dunnett NNP cord-010119-t1x9gknd 1164 8 's 's POS cord-010119-t1x9gknd 1164 9 post post JJ cord-010119-t1x9gknd 1164 10 - - JJ cord-010119-t1x9gknd 1164 11 test test NN cord-010119-t1x9gknd 1164 12 for for IN cord-010119-t1x9gknd 1164 13 multiple multiple JJ cord-010119-t1x9gknd 1164 14 comparisons comparison NNS cord-010119-t1x9gknd 1164 15 . . . cord-010119-t1x9gknd 1165 1 Data datum NNS cord-010119-t1x9gknd 1165 2 are be VBP cord-010119-t1x9gknd 1165 3 mean mean JJ cord-010119-t1x9gknd 1165 4 6 6 CD cord-010119-t1x9gknd 1165 5 SD sd NN cord-010119-t1x9gknd 1165 6 of of IN cord-010119-t1x9gknd 1165 7 % % NN cord-010119-t1x9gknd 1165 8 of of IN cord-010119-t1x9gknd 1165 9 control control NN cord-010119-t1x9gknd 1165 10 values value NNS cord-010119-t1x9gknd 1165 11 . . . cord-010119-t1x9gknd 1166 1 Results/ Results/ . cord-010119-t1x9gknd 1167 1 Finding finding NN cord-010119-t1x9gknd 1167 2 : : : cord-010119-t1x9gknd 1168 1 Exposure exposure NN cord-010119-t1x9gknd 1168 2 to to IN cord-010119-t1x9gknd 1168 3 apheresis apheresis NN cord-010119-t1x9gknd 1168 4 or or CC cord-010119-t1x9gknd 1168 5 WBD WBD NNP cord-010119-t1x9gknd 1168 6 RBC RBC NNP cord-010119-t1x9gknd 1168 7 supernatants supernatant NNS cord-010119-t1x9gknd 1168 8 suppressed suppress VBD cord-010119-t1x9gknd 1168 9 monocyte monocyte NNP cord-010119-t1x9gknd 1168 10 LPS LPS NNP cord-010119-t1x9gknd 1168 11 - - HYPH cord-010119-t1x9gknd 1168 12 induced induce VBN cord-010119-t1x9gknd 1168 13 TNFa TNFa NNP cord-010119-t1x9gknd 1168 14 production production NN cord-010119-t1x9gknd 1168 15 capacity capacity NN cord-010119-t1x9gknd 1168 16 compared compare VBN cord-010119-t1x9gknd 1168 17 to to IN cord-010119-t1x9gknd 1168 18 controls control NNS cord-010119-t1x9gknd 1168 19 ( ( -LRB- cord-010119-t1x9gknd 1168 20 Table table NN cord-010119-t1x9gknd 1168 21 1 1 CD cord-010119-t1x9gknd 1168 22 ) ) -RRB- cord-010119-t1x9gknd 1168 23 . . . cord-010119-t1x9gknd 1169 1 This this DT cord-010119-t1x9gknd 1169 2 was be VBD cord-010119-t1x9gknd 1169 3 true true JJ cord-010119-t1x9gknd 1169 4 for for IN cord-010119-t1x9gknd 1169 5 fresh fresh JJ cord-010119-t1x9gknd 1169 6 units unit NNS cord-010119-t1x9gknd 1169 7 and and CC cord-010119-t1x9gknd 1169 8 those those DT cord-010119-t1x9gknd 1169 9 at at IN cord-010119-t1x9gknd 1169 10 expiry expiry NN cord-010119-t1x9gknd 1169 11 . . . cord-010119-t1x9gknd 1170 1 For for IN cord-010119-t1x9gknd 1170 2 monocytes monocyte NNS cord-010119-t1x9gknd 1170 3 exposed expose VBN cord-010119-t1x9gknd 1170 4 to to IN cord-010119-t1x9gknd 1170 5 RBC RBC NNP cord-010119-t1x9gknd 1170 6 supernatant supernatant JJ cord-010119-t1x9gknd 1170 7 alone alone RB cord-010119-t1x9gknd 1170 8 without without IN cord-010119-t1x9gknd 1170 9 LPS lp NNS cord-010119-t1x9gknd 1170 10 , , , cord-010119-t1x9gknd 1170 11 interleukin-8 interleukin-8 NNP cord-010119-t1x9gknd 1170 12 production production NN cord-010119-t1x9gknd 1170 13 was be VBD cord-010119-t1x9gknd 1170 14 higher high JJR cord-010119-t1x9gknd 1170 15 after after IN cord-010119-t1x9gknd 1170 16 exposure exposure NN cord-010119-t1x9gknd 1170 17 to to IN cord-010119-t1x9gknd 1170 18 fresh fresh JJ cord-010119-t1x9gknd 1170 19 WBF WBF NNP cord-010119-t1x9gknd 1170 20 ( ( -LRB- cord-010119-t1x9gknd 1170 21 248 248 CD cord-010119-t1x9gknd 1170 22 6 6 CD cord-010119-t1x9gknd 1170 23 115 115 CD cord-010119-t1x9gknd 1170 24 % % NN cord-010119-t1x9gknd 1170 25 control control NN cord-010119-t1x9gknd 1170 26 , , , cord-010119-t1x9gknd 1170 27 p p NN cord-010119-t1x9gknd 1170 28 5 5 CD cord-010119-t1x9gknd 1170 29 0.02 0.02 CD cord-010119-t1x9gknd 1170 30 ) ) -RRB- cord-010119-t1x9gknd 1170 31 or or CC cord-010119-t1x9gknd 1170 32 WBD WBD NNP cord-010119-t1x9gknd 1170 33 at at IN cord-010119-t1x9gknd 1170 34 expiry expiry NN cord-010119-t1x9gknd 1170 35 ( ( -LRB- cord-010119-t1x9gknd 1170 36 292 292 CD cord-010119-t1x9gknd 1170 37 6 6 CD cord-010119-t1x9gknd 1170 38 111 111 CD cord-010119-t1x9gknd 1170 39 % % NN cord-010119-t1x9gknd 1170 40 control control NN cord-010119-t1x9gknd 1170 41 , , , cord-010119-t1x9gknd 1170 42 p p NN cord-010119-t1x9gknd 1170 43 5 5 CD cord-010119-t1x9gknd 1170 44 0.0005 0.0005 CD cord-010119-t1x9gknd 1170 45 ) ) -RRB- cord-010119-t1x9gknd 1170 46 . . . cord-010119-t1x9gknd 1171 1 Conclusion conclusion NN cord-010119-t1x9gknd 1171 2 : : : cord-010119-t1x9gknd 1172 1 Manufacturing manufacturing NN cord-010119-t1x9gknd 1172 2 method method NN cord-010119-t1x9gknd 1172 3 and/or and/or CC cord-010119-t1x9gknd 1172 4 storage storage NN cord-010119-t1x9gknd 1172 5 solution solution NN cord-010119-t1x9gknd 1172 6 significantly significantly RB cord-010119-t1x9gknd 1172 7 alters alter VBZ cord-010119-t1x9gknd 1172 8 immunomodulatory immunomodulatory JJ cord-010119-t1x9gknd 1172 9 effects effect NNS cord-010119-t1x9gknd 1172 10 of of IN cord-010119-t1x9gknd 1172 11 RBC RBC NNP cord-010119-t1x9gknd 1172 12 supernatant supernatant JJ cord-010119-t1x9gknd 1172 13 on on IN cord-010119-t1x9gknd 1172 14 monocytes monocyte NNS cord-010119-t1x9gknd 1172 15 in in IN cord-010119-t1x9gknd 1172 16 vitro vitro FW cord-010119-t1x9gknd 1172 17 and and CC cord-010119-t1x9gknd 1172 18 may may MD cord-010119-t1x9gknd 1172 19 confound confound VB cord-010119-t1x9gknd 1172 20 analyses analysis NNS cord-010119-t1x9gknd 1172 21 of of IN cord-010119-t1x9gknd 1172 22 clinical clinical JJ cord-010119-t1x9gknd 1172 23 effects effect NNS cord-010119-t1x9gknd 1172 24 of of IN cord-010119-t1x9gknd 1172 25 RBC RBC NNP cord-010119-t1x9gknd 1172 26 storage storage NN cord-010119-t1x9gknd 1172 27 duration duration NN cord-010119-t1x9gknd 1172 28 , , , cord-010119-t1x9gknd 1172 29 particularly particularly RB cord-010119-t1x9gknd 1172 30 within within IN cord-010119-t1x9gknd 1172 31 international international JJ cord-010119-t1x9gknd 1172 32 multi multi JJ cord-010119-t1x9gknd 1172 33 - - JJ cord-010119-t1x9gknd 1172 34 center center JJ cord-010119-t1x9gknd 1172 35 studies study NNS cord-010119-t1x9gknd 1172 36 . . . cord-010119-t1x9gknd 1173 1 A a DT cord-010119-t1x9gknd 1173 2 Magnetic magnetic JJ cord-010119-t1x9gknd 1173 3 Levitation Levitation NNP cord-010119-t1x9gknd 1173 4 System System NNP cord-010119-t1x9gknd 1173 5 to to TO cord-010119-t1x9gknd 1173 6 Study study VB cord-010119-t1x9gknd 1173 7 the the DT cord-010119-t1x9gknd 1173 8 Impact Impact NNP cord-010119-t1x9gknd 1173 9 of of IN cord-010119-t1x9gknd 1173 10 Donor Donor NNP cord-010119-t1x9gknd 1173 11 Gender Gender NNP cord-010119-t1x9gknd 1173 12 , , , cord-010119-t1x9gknd 1173 13 Age Age NNP cord-010119-t1x9gknd 1173 14 and and CC cord-010119-t1x9gknd 1173 15 Blood Blood NNP cord-010119-t1x9gknd 1173 16 Storage Storage NNP cord-010119-t1x9gknd 1173 17 Conditions condition NNS cord-010119-t1x9gknd 1173 18 on on IN cord-010119-t1x9gknd 1173 19 Red Red NNP cord-010119-t1x9gknd 1173 20 Blood Blood NNP cord-010119-t1x9gknd 1173 21 Cell cell NN cord-010119-t1x9gknd 1173 22 Density density NN cord-010119-t1x9gknd 1173 23 Profile Profile NNP cord-010119-t1x9gknd 1173 24 Gozde Gozde NNP cord-010119-t1x9gknd 1173 25 Durmus Durmus NNP cord-010119-t1x9gknd 1174 1 * * NFP cord-010119-t1x9gknd 1174 2 1 1 CD cord-010119-t1x9gknd 1174 3 , , , cord-010119-t1x9gknd 1174 4 Alessandro Alessandro NNP cord-010119-t1x9gknd 1174 5 Tocchio Tocchio NNP cord-010119-t1x9gknd 1174 6 1 1 CD cord-010119-t1x9gknd 1174 7 , , , cord-010119-t1x9gknd 1174 8 Anita Anita NNP cord-010119-t1x9gknd 1174 9 Howell Howell NNP cord-010119-t1x9gknd 1174 10 2 2 CD cord-010119-t1x9gknd 1174 11 , , , cord-010119-t1x9gknd 1174 12 Kaushik Kaushik NNP cord-010119-t1x9gknd 1174 13 Sridhar Sridhar NNP cord-010119-t1x9gknd 1174 14 1 1 CD cord-010119-t1x9gknd 1174 15 , , , cord-010119-t1x9gknd 1174 16 Jason Jason NNP cord-010119-t1x9gknd 1174 17 P. P. NNP cord-010119-t1x9gknd 1174 18 Acker Acker NNP cord-010119-t1x9gknd 1174 19 3 3 CD cord-010119-t1x9gknd 1174 20 and and CC cord-010119-t1x9gknd 1174 21 Utkan Utkan NNP cord-010119-t1x9gknd 1174 22 Demirci Demirci NNP cord-010119-t1x9gknd 1175 1 1 1 LS cord-010119-t1x9gknd 1175 2 . . . cord-010119-t1x9gknd 1175 3 1 1 CD cord-010119-t1x9gknd 1175 4 Stanford Stanford NNP cord-010119-t1x9gknd 1175 5 University University NNP cord-010119-t1x9gknd 1175 6 , , , cord-010119-t1x9gknd 1175 7 2 2 CD cord-010119-t1x9gknd 1175 8 Canadian Canadian NNP cord-010119-t1x9gknd 1175 9 Blood Blood NNP cord-010119-t1x9gknd 1175 10 Services Services NNPS cord-010119-t1x9gknd 1175 11 , , , cord-010119-t1x9gknd 1175 12 Centre Centre NNP cord-010119-t1x9gknd 1175 13 for for IN cord-010119-t1x9gknd 1175 14 Innovation Innovation NNP cord-010119-t1x9gknd 1175 15 , , , cord-010119-t1x9gknd 1175 16 3 3 CD cord-010119-t1x9gknd 1175 17 _SP cord-010119-t1x9gknd 1175 18 Background Background NNP cord-010119-t1x9gknd 1175 19 / / SYM cord-010119-t1x9gknd 1175 20 Case Case NNP cord-010119-t1x9gknd 1175 21 Studies Studies NNPS cord-010119-t1x9gknd 1175 22 : : : cord-010119-t1x9gknd 1176 1 The the DT cord-010119-t1x9gknd 1176 2 amount amount NN cord-010119-t1x9gknd 1176 3 of of IN cord-010119-t1x9gknd 1176 4 hemolysis hemolysis NN cord-010119-t1x9gknd 1176 5 in in IN cord-010119-t1x9gknd 1176 6 red red JJ cord-010119-t1x9gknd 1176 7 blood blood NN cord-010119-t1x9gknd 1176 8 cell cell NN cord-010119-t1x9gknd 1176 9 units unit NNS cord-010119-t1x9gknd 1176 10 increases increase VBZ cord-010119-t1x9gknd 1176 11 as as IN cord-010119-t1x9gknd 1176 12 the the DT cord-010119-t1x9gknd 1176 13 product product NN cord-010119-t1x9gknd 1176 14 ages age NNS cord-010119-t1x9gknd 1176 15 and and CC cord-010119-t1x9gknd 1176 16 has have VBZ cord-010119-t1x9gknd 1176 17 been be VBN cord-010119-t1x9gknd 1176 18 shown show VBN cord-010119-t1x9gknd 1176 19 to to TO cord-010119-t1x9gknd 1176 20 be be VB cord-010119-t1x9gknd 1176 21 lower low JJR cord-010119-t1x9gknd 1176 22 in in IN cord-010119-t1x9gknd 1176 23 female female JJ cord-010119-t1x9gknd 1176 24 blood blood NN cord-010119-t1x9gknd 1176 25 donors donor NNS cord-010119-t1x9gknd 1176 26 than than IN cord-010119-t1x9gknd 1176 27 in in IN cord-010119-t1x9gknd 1176 28 males male NNS cord-010119-t1x9gknd 1176 29 . . . cord-010119-t1x9gknd 1177 1 It -PRON- PRP cord-010119-t1x9gknd 1177 2 is be VBZ cord-010119-t1x9gknd 1177 3 hypothesized hypothesize VBN cord-010119-t1x9gknd 1177 4 that that IN cord-010119-t1x9gknd 1177 5 female female JJ cord-010119-t1x9gknd 1177 6 donors donor NNS cord-010119-t1x9gknd 1177 7 possess possess VBP cord-010119-t1x9gknd 1177 8 , , , cord-010119-t1x9gknd 1177 9 on on IN cord-010119-t1x9gknd 1177 10 average average JJ cord-010119-t1x9gknd 1177 11 , , , cord-010119-t1x9gknd 1177 12 a a DT cord-010119-t1x9gknd 1177 13 younger young JJR cord-010119-t1x9gknd 1177 14 population population NN cord-010119-t1x9gknd 1177 15 of of IN cord-010119-t1x9gknd 1177 16 red red JJ cord-010119-t1x9gknd 1177 17 cells cell NNS cord-010119-t1x9gknd 1177 18 , , , cord-010119-t1x9gknd 1177 19 which which WDT cord-010119-t1x9gknd 1177 20 results result VBZ cord-010119-t1x9gknd 1177 21 in in IN cord-010119-t1x9gknd 1177 22 the the DT cord-010119-t1x9gknd 1177 23 lower low JJR cord-010119-t1x9gknd 1177 24 hemolysis hemolysis NN cord-010119-t1x9gknd 1177 25 that that WDT cord-010119-t1x9gknd 1177 26 is be VBZ cord-010119-t1x9gknd 1177 27 observed observe VBN cord-010119-t1x9gknd 1177 28 in in IN cord-010119-t1x9gknd 1177 29 the the DT cord-010119-t1x9gknd 1177 30 pre pre JJ cord-010119-t1x9gknd 1177 31 - - JJ cord-010119-t1x9gknd 1177 32 menopausal menopausal JJ cord-010119-t1x9gknd 1177 33 population population NN cord-010119-t1x9gknd 1177 34 . . . cord-010119-t1x9gknd 1178 1 It -PRON- PRP cord-010119-t1x9gknd 1178 2 is be VBZ cord-010119-t1x9gknd 1178 3 also also RB cord-010119-t1x9gknd 1178 4 hypothesized hypothesize VBN cord-010119-t1x9gknd 1178 5 that that IN cord-010119-t1x9gknd 1178 6 the the DT cord-010119-t1x9gknd 1178 7 differences difference NNS cord-010119-t1x9gknd 1178 8 between between IN cord-010119-t1x9gknd 1178 9 donor donor NN cord-010119-t1x9gknd 1178 10 populations population NNS cord-010119-t1x9gknd 1178 11 are be VBP cord-010119-t1x9gknd 1178 12 mitigated mitigate VBN cord-010119-t1x9gknd 1178 13 by by IN cord-010119-t1x9gknd 1178 14 lysis lysis NN cord-010119-t1x9gknd 1178 15 of of IN cord-010119-t1x9gknd 1178 16 older old JJR cord-010119-t1x9gknd 1178 17 cells cell NNS cord-010119-t1x9gknd 1178 18 when when WRB cord-010119-t1x9gknd 1178 19 whole whole JJ cord-010119-t1x9gknd 1178 20 blood blood NN cord-010119-t1x9gknd 1178 21 units unit NNS cord-010119-t1x9gknd 1178 22 undergo undergo VBP cord-010119-t1x9gknd 1178 23 processing processing NN cord-010119-t1x9gknd 1178 24 steps step NNS cord-010119-t1x9gknd 1178 25 to to TO cord-010119-t1x9gknd 1178 26 produce produce VB cord-010119-t1x9gknd 1178 27 red red JJ cord-010119-t1x9gknd 1178 28 cell cell NN cord-010119-t1x9gknd 1178 29 concentrate concentrate NN cord-010119-t1x9gknd 1178 30 ( ( -LRB- cord-010119-t1x9gknd 1178 31 RCC RCC NNP cord-010119-t1x9gknd 1178 32 ) ) -RRB- cord-010119-t1x9gknd 1178 33 units unit NNS cord-010119-t1x9gknd 1178 34 . . . cord-010119-t1x9gknd 1179 1 As as IN cord-010119-t1x9gknd 1179 2 red red JJ cord-010119-t1x9gknd 1179 3 blood blood NN cord-010119-t1x9gknd 1179 4 cells cell NNS cord-010119-t1x9gknd 1179 5 ( ( -LRB- cord-010119-t1x9gknd 1179 6 RBCs rbc NNS cord-010119-t1x9gknd 1179 7 ) ) -RRB- cord-010119-t1x9gknd 1179 8 age age NN cord-010119-t1x9gknd 1179 9 in in IN cord-010119-t1x9gknd 1179 10 circulation circulation NN cord-010119-t1x9gknd 1179 11 , , , cord-010119-t1x9gknd 1179 12 they -PRON- PRP cord-010119-t1x9gknd 1179 13 undergo undergo VBP cord-010119-t1x9gknd 1179 14 characteristic characteristic JJ cord-010119-t1x9gknd 1179 15 changes change NNS cord-010119-t1x9gknd 1179 16 in in IN cord-010119-t1x9gknd 1179 17 density density NN cord-010119-t1x9gknd 1179 18 and and CC cord-010119-t1x9gknd 1179 19 membrane membrane NN cord-010119-t1x9gknd 1179 20 composition composition NN cord-010119-t1x9gknd 1179 21 that that WDT cord-010119-t1x9gknd 1179 22 allows allow VBZ cord-010119-t1x9gknd 1179 23 for for IN cord-010119-t1x9gknd 1179 24 them -PRON- PRP cord-010119-t1x9gknd 1179 25 to to TO cord-010119-t1x9gknd 1179 26 be be VB cord-010119-t1x9gknd 1179 27 separated separate VBN cord-010119-t1x9gknd 1179 28 from from IN cord-010119-t1x9gknd 1179 29 younger young JJR cord-010119-t1x9gknd 1179 30 cells cell NNS cord-010119-t1x9gknd 1179 31 . . . cord-010119-t1x9gknd 1180 1 Study Study NNP cord-010119-t1x9gknd 1180 2 Design Design NNP cord-010119-t1x9gknd 1180 3 / / SYM cord-010119-t1x9gknd 1180 4 Method method NN cord-010119-t1x9gknd 1180 5 : : : cord-010119-t1x9gknd 1181 1 Our -PRON- PRP$ cord-010119-t1x9gknd 1181 2 aim aim NN cord-010119-t1x9gknd 1181 3 is be VBZ cord-010119-t1x9gknd 1181 4 to to TO cord-010119-t1x9gknd 1181 5 study study VB cord-010119-t1x9gknd 1181 6 the the DT cord-010119-t1x9gknd 1181 7 effect effect NN cord-010119-t1x9gknd 1181 8 of of IN cord-010119-t1x9gknd 1181 9 donor donor NN cord-010119-t1x9gknd 1181 10 factors factor NNS cord-010119-t1x9gknd 1181 11 and and CC cord-010119-t1x9gknd 1181 12 method method NN cord-010119-t1x9gknd 1181 13 of of IN cord-010119-t1x9gknd 1181 14 manufacturing manufacturing NN cord-010119-t1x9gknd 1181 15 and and CC cord-010119-t1x9gknd 1181 16 storing store VBG cord-010119-t1x9gknd 1181 17 conditions condition NNS cord-010119-t1x9gknd 1181 18 on on IN cord-010119-t1x9gknd 1181 19 the the DT cord-010119-t1x9gknd 1181 20 average average JJ cord-010119-t1x9gknd 1181 21 RBC RBC NNP cord-010119-t1x9gknd 1181 22 age age NN cord-010119-t1x9gknd 1181 23 and and CC cord-010119-t1x9gknd 1181 24 density density NN cord-010119-t1x9gknd 1181 25 of of IN cord-010119-t1x9gknd 1181 26 red red JJ cord-010119-t1x9gknd 1181 27 cell cell NN cord-010119-t1x9gknd 1181 28 units unit NNS cord-010119-t1x9gknd 1181 29 . . . cord-010119-t1x9gknd 1182 1 We -PRON- PRP cord-010119-t1x9gknd 1182 2 have have VBP cord-010119-t1x9gknd 1182 3 recently recently RB cord-010119-t1x9gknd 1182 4 developed develop VBN cord-010119-t1x9gknd 1182 5 a a DT cord-010119-t1x9gknd 1182 6 powerful powerful JJ cord-010119-t1x9gknd 1182 7 yet yet CC cord-010119-t1x9gknd 1182 8 simple simple JJ cord-010119-t1x9gknd 1182 9 and and CC cord-010119-t1x9gknd 1182 10 inexpensive inexpensive JJ cord-010119-t1x9gknd 1182 11 magnetic magnetic JJ cord-010119-t1x9gknd 1182 12 levitation levitation NN cord-010119-t1x9gknd 1182 13 - - HYPH cord-010119-t1x9gknd 1182 14 based base VBN cord-010119-t1x9gknd 1182 15 platform platform NN cord-010119-t1x9gknd 1182 16 , , , cord-010119-t1x9gknd 1182 17 which which WDT cord-010119-t1x9gknd 1182 18 allows allow VBZ cord-010119-t1x9gknd 1182 19 realtime realtime NN cord-010119-t1x9gknd 1182 20 , , , cord-010119-t1x9gknd 1182 21 high high JJ cord-010119-t1x9gknd 1182 22 - - HYPH cord-010119-t1x9gknd 1182 23 resolution resolution NN cord-010119-t1x9gknd 1182 24 imaging imaging NN cord-010119-t1x9gknd 1182 25 and and CC cord-010119-t1x9gknd 1182 26 monitoring monitoring NN cord-010119-t1x9gknd 1182 27 of of IN cord-010119-t1x9gknd 1182 28 various various JJ cord-010119-t1x9gknd 1182 29 cell cell NN cord-010119-t1x9gknd 1182 30 populations population NNS cord-010119-t1x9gknd 1182 31 . . . cord-010119-t1x9gknd 1183 1 This this DT cord-010119-t1x9gknd 1183 2 label label NN cord-010119-t1x9gknd 1183 3 - - HYPH cord-010119-t1x9gknd 1183 4 free free JJ cord-010119-t1x9gknd 1183 5 system system NN cord-010119-t1x9gknd 1183 6 allows allow VBZ cord-010119-t1x9gknd 1183 7 density density NN cord-010119-t1x9gknd 1183 8 profiling profiling NN cord-010119-t1x9gknd 1183 9 for for IN cord-010119-t1x9gknd 1183 10 individual individual JJ cord-010119-t1x9gknd 1183 11 red red JJ cord-010119-t1x9gknd 1183 12 blood blood NN cord-010119-t1x9gknd 1183 13 cells cell NNS cord-010119-t1x9gknd 1183 14 , , , cord-010119-t1x9gknd 1183 15 with with IN cord-010119-t1x9gknd 1183 16 an an DT cord-010119-t1x9gknd 1183 17 unprecedented unprecedented JJ cord-010119-t1x9gknd 1183 18 resolution resolution NN cord-010119-t1x9gknd 1183 19 of of IN cord-010119-t1x9gknd 1183 20 10 10 CD cord-010119-t1x9gknd 1183 21 -4 -4 NN cord-010119-t1x9gknd 1183 22 g g NN cord-010119-t1x9gknd 1183 23 / / SYM cord-010119-t1x9gknd 1183 24 mL. mL. NNP cord-010119-t1x9gknd 1183 25 First First NNP cord-010119-t1x9gknd 1183 26 , , , cord-010119-t1x9gknd 1183 27 to to TO cord-010119-t1x9gknd 1183 28 determine determine VB cord-010119-t1x9gknd 1183 29 the the DT cord-010119-t1x9gknd 1183 30 effect effect NN cord-010119-t1x9gknd 1183 31 of of IN cord-010119-t1x9gknd 1183 32 RCC RCC NNP cord-010119-t1x9gknd 1183 33 storage storage NN cord-010119-t1x9gknd 1183 34 on on IN cord-010119-t1x9gknd 1183 35 the the DT cord-010119-t1x9gknd 1183 36 density density NN cord-010119-t1x9gknd 1183 37 profile profile NN cord-010119-t1x9gknd 1183 38 of of IN cord-010119-t1x9gknd 1183 39 RBCs rbc NNS cord-010119-t1x9gknd 1183 40 , , , cord-010119-t1x9gknd 1183 41 levitation levitation NN cord-010119-t1x9gknd 1183 42 and and CC cord-010119-t1x9gknd 1183 43 single single JJ cord-010119-t1x9gknd 1183 44 - - HYPH cord-010119-t1x9gknd 1183 45 cell cell NN cord-010119-t1x9gknd 1183 46 density density NN cord-010119-t1x9gknd 1183 47 profiles profile NNS cord-010119-t1x9gknd 1183 48 were be VBD cord-010119-t1x9gknd 1183 49 measured measure VBN cord-010119-t1x9gknd 1183 50 at at IN cord-010119-t1x9gknd 1183 51 7 7 CD cord-010119-t1x9gknd 1183 52 , , , cord-010119-t1x9gknd 1183 53 14 14 CD cord-010119-t1x9gknd 1183 54 , , , cord-010119-t1x9gknd 1183 55 21 21 CD cord-010119-t1x9gknd 1183 56 , , , cord-010119-t1x9gknd 1183 57 28 28 CD cord-010119-t1x9gknd 1183 58 , , , cord-010119-t1x9gknd 1183 59 35 35 CD cord-010119-t1x9gknd 1183 60 and and CC cord-010119-t1x9gknd 1183 61 42 42 CD cord-010119-t1x9gknd 1183 62 days day NNS cord-010119-t1x9gknd 1183 63 . . . cord-010119-t1x9gknd 1184 1 In in IN cord-010119-t1x9gknd 1184 2 addition addition NN cord-010119-t1x9gknd 1184 3 , , , cord-010119-t1x9gknd 1184 4 to to TO cord-010119-t1x9gknd 1184 5 determine determine VB cord-010119-t1x9gknd 1184 6 the the DT cord-010119-t1x9gknd 1184 7 effect effect NN cord-010119-t1x9gknd 1184 8 of of IN cord-010119-t1x9gknd 1184 9 donor donor NN cord-010119-t1x9gknd 1184 10 age age NN cord-010119-t1x9gknd 1184 11 and and CC cord-010119-t1x9gknd 1184 12 sex sex NN cord-010119-t1x9gknd 1184 13 on on IN cord-010119-t1x9gknd 1184 14 the the DT cord-010119-t1x9gknd 1184 15 RBC RBC NNP cord-010119-t1x9gknd 1184 16 density density NN cord-010119-t1x9gknd 1184 17 profile profile NN cord-010119-t1x9gknd 1184 18 , , , cord-010119-t1x9gknd 1184 19 blood blood NN cord-010119-t1x9gknd 1184 20 samples sample NNS cord-010119-t1x9gknd 1184 21 from from IN cord-010119-t1x9gknd 1184 22 24 24 CD cord-010119-t1x9gknd 1184 23 volunteers volunteer NNS cord-010119-t1x9gknd 1184 24 with with IN cord-010119-t1x9gknd 1184 25 four four CD cord-010119-t1x9gknd 1184 26 different different JJ cord-010119-t1x9gknd 1184 27 age age NN cord-010119-t1x9gknd 1184 28 and and CC cord-010119-t1x9gknd 1184 29 sex sex NN cord-010119-t1x9gknd 1184 30 categories category NNS cord-010119-t1x9gknd 1184 31 ( ( -LRB- cord-010119-t1x9gknd 1184 32 Male male JJ cord-010119-t1x9gknd 1184 33 , , , cord-010119-t1x9gknd 1184 34 18 18 CD cord-010119-t1x9gknd 1184 35 - - SYM cord-010119-t1x9gknd 1184 36 40 40 CD cord-010119-t1x9gknd 1184 37 years year NNS cord-010119-t1x9gknd 1184 38 ; ; : cord-010119-t1x9gknd 1184 39 Male male JJ cord-010119-t1x9gknd 1184 40 , , , cord-010119-t1x9gknd 1184 41 > > XX cord-010119-t1x9gknd 1184 42 60 60 CD cord-010119-t1x9gknd 1184 43 years year NNS cord-010119-t1x9gknd 1184 44 ; ; : cord-010119-t1x9gknd 1184 45 Female female JJ cord-010119-t1x9gknd 1184 46 , , , cord-010119-t1x9gknd 1184 47 18 18 CD cord-010119-t1x9gknd 1184 48 - - SYM cord-010119-t1x9gknd 1184 49 40 40 CD cord-010119-t1x9gknd 1184 50 years year NNS cord-010119-t1x9gknd 1184 51 ; ; : cord-010119-t1x9gknd 1184 52 Female female JJ cord-010119-t1x9gknd 1184 53 , , , cord-010119-t1x9gknd 1184 54 > > XX cord-010119-t1x9gknd 1184 55 60 60 CD cord-010119-t1x9gknd 1184 56 years year NNS cord-010119-t1x9gknd 1184 57 ) ) -RRB- cord-010119-t1x9gknd 1184 58 were be VBD cord-010119-t1x9gknd 1184 59 profiled profile VBN cord-010119-t1x9gknd 1184 60 . . . cord-010119-t1x9gknd 1185 1 Results/ Results/ . cord-010119-t1x9gknd 1186 1 Finding finding NN cord-010119-t1x9gknd 1186 2 : : : cord-010119-t1x9gknd 1187 1 First first RB cord-010119-t1x9gknd 1187 2 , , , cord-010119-t1x9gknd 1187 3 we -PRON- PRP cord-010119-t1x9gknd 1187 4 observed observe VBD cord-010119-t1x9gknd 1187 5 that that IN cord-010119-t1x9gknd 1187 6 the the DT cord-010119-t1x9gknd 1187 7 levitation levitation NN cord-010119-t1x9gknd 1187 8 and and CC cord-010119-t1x9gknd 1187 9 density density NN cord-010119-t1x9gknd 1187 10 profiles profile NNS cord-010119-t1x9gknd 1187 11 as as RB cord-010119-t1x9gknd 1187 12 well well RB cord-010119-t1x9gknd 1187 13 as as IN cord-010119-t1x9gknd 1187 14 morphology morphology NN cord-010119-t1x9gknd 1187 15 of of IN cord-010119-t1x9gknd 1187 16 RBCs rbc NNS cord-010119-t1x9gknd 1187 17 within within IN cord-010119-t1x9gknd 1187 18 RCC RCC NNP cord-010119-t1x9gknd 1187 19 units unit NNS cord-010119-t1x9gknd 1187 20 change change VBP cord-010119-t1x9gknd 1187 21 significantly significantly RB cord-010119-t1x9gknd 1187 22 during during IN cord-010119-t1x9gknd 1187 23 storage storage NN cord-010119-t1x9gknd 1187 24 . . . cord-010119-t1x9gknd 1188 1 In in IN cord-010119-t1x9gknd 1188 2 addition addition NN cord-010119-t1x9gknd 1188 3 , , , cord-010119-t1x9gknd 1188 4 RBC RBC NNP cord-010119-t1x9gknd 1188 5 density density NN cord-010119-t1x9gknd 1188 6 was be VBD cord-010119-t1x9gknd 1188 7 significantly significantly RB cord-010119-t1x9gknd 1188 8 different different JJ cord-010119-t1x9gknd 1188 9 between between IN cord-010119-t1x9gknd 1188 10 young young JJ cord-010119-t1x9gknd 1188 11 ( ( -LRB- cord-010119-t1x9gknd 1188 12 1.098 1.098 CD cord-010119-t1x9gknd 1188 13 g g NN cord-010119-t1x9gknd 1188 14 / / SYM cord-010119-t1x9gknd 1188 15 mL mL NNP cord-010119-t1x9gknd 1188 16 ) ) -RRB- cord-010119-t1x9gknd 1188 17 and and CC cord-010119-t1x9gknd 1188 18 older old JJR cord-010119-t1x9gknd 1188 19 female female JJ cord-010119-t1x9gknd 1188 20 donors donor NNS cord-010119-t1x9gknd 1188 21 ( ( -LRB- cord-010119-t1x9gknd 1188 22 1.109 1.109 CD cord-010119-t1x9gknd 1188 23 g g NN cord-010119-t1x9gknd 1188 24 / / SYM cord-010119-t1x9gknd 1188 25 mL ml NN cord-010119-t1x9gknd 1188 26 ) ) -RRB- cord-010119-t1x9gknd 1189 1 ( ( -LRB- cord-010119-t1x9gknd 1189 2 p p NN cord-010119-t1x9gknd 1189 3 < < XX cord-010119-t1x9gknd 1189 4 0.01 0.01 CD cord-010119-t1x9gknd 1189 5 ) ) -RRB- cord-010119-t1x9gknd 1189 6 . . . cord-010119-t1x9gknd 1190 1 Moreover moreover RB cord-010119-t1x9gknd 1190 2 , , , cord-010119-t1x9gknd 1190 3 RBCs rbc NNS cord-010119-t1x9gknd 1190 4 from from IN cord-010119-t1x9gknd 1190 5 young young JJ cord-010119-t1x9gknd 1190 6 males male NNS cord-010119-t1x9gknd 1190 7 ( ( -LRB- cord-010119-t1x9gknd 1190 8 1.096 1.096 CD cord-010119-t1x9gknd 1190 9 g g NN cord-010119-t1x9gknd 1190 10 / / SYM cord-010119-t1x9gknd 1190 11 mL ml NN cord-010119-t1x9gknd 1190 12 ) ) -RRB- cord-010119-t1x9gknd 1190 13 were be VBD cord-010119-t1x9gknd 1190 14 significantly significantly RB cord-010119-t1x9gknd 1190 15 less less RBR cord-010119-t1x9gknd 1190 16 dense dense JJ cord-010119-t1x9gknd 1190 17 compared compare VBN cord-010119-t1x9gknd 1190 18 to to IN cord-010119-t1x9gknd 1190 19 RBCs rbc NNS cord-010119-t1x9gknd 1190 20 profiled profile VBN cord-010119-t1x9gknd 1190 21 from from IN cord-010119-t1x9gknd 1190 22 older old JJR cord-010119-t1x9gknd 1190 23 female female JJ cord-010119-t1x9gknd 1190 24 donors donor NNS cord-010119-t1x9gknd 1190 25 ( ( -LRB- cord-010119-t1x9gknd 1190 26 1.109 1.109 CD cord-010119-t1x9gknd 1190 27 g g NN cord-010119-t1x9gknd 1190 28 / / SYM cord-010119-t1x9gknd 1190 29 mL ml NN cord-010119-t1x9gknd 1190 30 ) ) -RRB- cord-010119-t1x9gknd 1190 31 ( ( -LRB- cord-010119-t1x9gknd 1190 32 p p NN cord-010119-t1x9gknd 1190 33 < < XX cord-010119-t1x9gknd 1190 34 0.05 0.05 CD cord-010119-t1x9gknd 1190 35 ) ) -RRB- cord-010119-t1x9gknd 1190 36 . . . cord-010119-t1x9gknd 1191 1 Conclusion conclusion NN cord-010119-t1x9gknd 1191 2 : : : cord-010119-t1x9gknd 1191 3 We -PRON- PRP cord-010119-t1x9gknd 1191 4 have have VBP cord-010119-t1x9gknd 1191 5 developed develop VBN cord-010119-t1x9gknd 1191 6 a a DT cord-010119-t1x9gknd 1191 7 magnetic magnetic JJ cord-010119-t1x9gknd 1191 8 levitation levitation NN cord-010119-t1x9gknd 1191 9 system system NN cord-010119-t1x9gknd 1191 10 for for IN cord-010119-t1x9gknd 1191 11 the the DT cord-010119-t1x9gknd 1191 12 point point NN cord-010119-t1x9gknd 1191 13 - - HYPH cord-010119-t1x9gknd 1191 14 of of IN cord-010119-t1x9gknd 1191 15 - - HYPH cord-010119-t1x9gknd 1191 16 care care NN cord-010119-t1x9gknd 1191 17 , , , cord-010119-t1x9gknd 1191 18 real real JJ cord-010119-t1x9gknd 1191 19 - - HYPH cord-010119-t1x9gknd 1191 20 time time NN cord-010119-t1x9gknd 1191 21 evaluation evaluation NN cord-010119-t1x9gknd 1191 22 of of IN cord-010119-t1x9gknd 1191 23 RBC RBC NNP cord-010119-t1x9gknd 1191 24 and and CC cord-010119-t1x9gknd 1191 25 red red JJ cord-010119-t1x9gknd 1191 26 cell cell NN cord-010119-t1x9gknd 1191 27 concentrate concentrate NN cord-010119-t1x9gknd 1191 28 ( ( -LRB- cord-010119-t1x9gknd 1191 29 RCC RCC NNP cord-010119-t1x9gknd 1191 30 ) ) -RRB- cord-010119-t1x9gknd 1191 31 quality quality NN cord-010119-t1x9gknd 1191 32 . . . cord-010119-t1x9gknd 1192 1 We -PRON- PRP cord-010119-t1x9gknd 1192 2 envision envision VBP cord-010119-t1x9gknd 1192 3 our -PRON- PRP$ cord-010119-t1x9gknd 1192 4 results result NNS cord-010119-t1x9gknd 1192 5 might may MD cord-010119-t1x9gknd 1192 6 inform inform VB cord-010119-t1x9gknd 1192 7 decision decision NN cord-010119-t1x9gknd 1192 8 makers maker NNS cord-010119-t1x9gknd 1192 9 about about IN cord-010119-t1x9gknd 1192 10 impact impact NN cord-010119-t1x9gknd 1192 11 that that DT cord-010119-t1x9gknd 1192 12 donor donor NN cord-010119-t1x9gknd 1192 13 deferral deferral NN cord-010119-t1x9gknd 1192 14 criteria criterion NNS cord-010119-t1x9gknd 1192 15 may may MD cord-010119-t1x9gknd 1192 16 be be VB cord-010119-t1x9gknd 1192 17 having have VBG cord-010119-t1x9gknd 1192 18 on on IN cord-010119-t1x9gknd 1192 19 the the DT cord-010119-t1x9gknd 1192 20 quality quality NN cord-010119-t1x9gknd 1192 21 of of IN cord-010119-t1x9gknd 1192 22 red red JJ cord-010119-t1x9gknd 1192 23 cell cell NN cord-010119-t1x9gknd 1192 24 concentrates concentrate VBZ cord-010119-t1x9gknd 1192 25 available available JJ cord-010119-t1x9gknd 1192 26 in in IN cord-010119-t1x9gknd 1192 27 the the DT cord-010119-t1x9gknd 1192 28 blood blood NN cord-010119-t1x9gknd 1192 29 banks bank NNS cord-010119-t1x9gknd 1192 30 , , , cord-010119-t1x9gknd 1192 31 for for IN cord-010119-t1x9gknd 1192 32 the the DT cord-010119-t1x9gknd 1192 33 optimal optimal JJ cord-010119-t1x9gknd 1192 34 clinical clinical JJ cord-010119-t1x9gknd 1192 35 outcomes outcome NNS cord-010119-t1x9gknd 1192 36 . . . cord-010119-t1x9gknd 1193 1 Cytokine cytokine NN cord-010119-t1x9gknd 1193 2 production production NN cord-010119-t1x9gknd 1193 3 of of IN cord-010119-t1x9gknd 1193 4 pulmonary pulmonary JJ cord-010119-t1x9gknd 1193 5 cells cell NNS cord-010119-t1x9gknd 1193 6 IL-6 IL-6 NNP cord-010119-t1x9gknd 1193 7 ( ( -LRB- cord-010119-t1x9gknd 1193 8 pg pg NNP cord-010119-t1x9gknd 1193 9 / / SYM cord-010119-t1x9gknd 1193 10 mL ml NN cord-010119-t1x9gknd 1193 11 ) ) -RRB- cord-010119-t1x9gknd 1194 1 IL-8 IL-8 NNP cord-010119-t1x9gknd 1194 2 ( ( -LRB- cord-010119-t1x9gknd 1194 3 pg pg NNP cord-010119-t1x9gknd 1194 4 / / SYM cord-010119-t1x9gknd 1194 5 mL mL NNP cord-010119-t1x9gknd 1194 6 ) ) -RRB- cord-010119-t1x9gknd 1194 7 Background Background NNP cord-010119-t1x9gknd 1194 8 / / SYM cord-010119-t1x9gknd 1194 9 Case Case NNP cord-010119-t1x9gknd 1194 10 Studies Studies NNPS cord-010119-t1x9gknd 1194 11 : : : cord-010119-t1x9gknd 1194 12 Oxidation oxidation NN cord-010119-t1x9gknd 1194 13 Reduction reduction NN cord-010119-t1x9gknd 1194 14 Potential Potential NNP cord-010119-t1x9gknd 1194 15 ( ( -LRB- cord-010119-t1x9gknd 1194 16 ORP ORP NNP cord-010119-t1x9gknd 1194 17 ) ) -RRB- cord-010119-t1x9gknd 1194 18 or or CC cord-010119-t1x9gknd 1194 19 Redox Redox NNP cord-010119-t1x9gknd 1194 20 is be VBZ cord-010119-t1x9gknd 1194 21 the the DT cord-010119-t1x9gknd 1194 22 ratio ratio NN cord-010119-t1x9gknd 1194 23 of of IN cord-010119-t1x9gknd 1194 24 activity activity NN cord-010119-t1x9gknd 1194 25 between between IN cord-010119-t1x9gknd 1194 26 oxidizers oxidizer NNS cord-010119-t1x9gknd 1194 27 and and CC cord-010119-t1x9gknd 1194 28 reducers reducer NNS cord-010119-t1x9gknd 1194 29 . . . cord-010119-t1x9gknd 1195 1 Redox redox JJ cord-010119-t1x9gknd 1195 2 imbalance imbalance NN cord-010119-t1x9gknd 1195 3 caused cause VBN cord-010119-t1x9gknd 1195 4 by by IN cord-010119-t1x9gknd 1195 5 a a DT cord-010119-t1x9gknd 1195 6 higher high JJR cord-010119-t1x9gknd 1195 7 production production NN cord-010119-t1x9gknd 1195 8 of of IN cord-010119-t1x9gknd 1195 9 reactive reactive JJ cord-010119-t1x9gknd 1195 10 oxygen oxygen NN cord-010119-t1x9gknd 1195 11 species specie NNS cord-010119-t1x9gknd 1195 12 ( ( -LRB- cord-010119-t1x9gknd 1195 13 ROS ROS NNP cord-010119-t1x9gknd 1195 14 ) ) -RRB- cord-010119-t1x9gknd 1195 15 and and CC cord-010119-t1x9gknd 1195 16 reactive reactive JJ cord-010119-t1x9gknd 1195 17 nitrogen nitrogen NN cord-010119-t1x9gknd 1195 18 species specie NNS cord-010119-t1x9gknd 1195 19 or or CC cord-010119-t1x9gknd 1195 20 a a DT cord-010119-t1x9gknd 1195 21 decrease decrease NN cord-010119-t1x9gknd 1195 22 in in IN cord-010119-t1x9gknd 1195 23 endogenous endogenous JJ cord-010119-t1x9gknd 1195 24 protective protective JJ cord-010119-t1x9gknd 1195 25 antioxidants antioxidant NNS cord-010119-t1x9gknd 1195 26 results result NNS cord-010119-t1x9gknd 1195 27 in in IN cord-010119-t1x9gknd 1195 28 oxidative oxidative JJ cord-010119-t1x9gknd 1195 29 stress stress NN cord-010119-t1x9gknd 1195 30 ( ( -LRB- cord-010119-t1x9gknd 1195 31 OS OS NNP cord-010119-t1x9gknd 1195 32 ) ) -RRB- cord-010119-t1x9gknd 1195 33 . . . cord-010119-t1x9gknd 1196 1 While while IN cord-010119-t1x9gknd 1196 2 OS OS NNP cord-010119-t1x9gknd 1196 3 can can MD cord-010119-t1x9gknd 1196 4 cause cause VB cord-010119-t1x9gknd 1196 5 cellular cellular JJ cord-010119-t1x9gknd 1196 6 injury injury NN cord-010119-t1x9gknd 1196 7 and and CC cord-010119-t1x9gknd 1196 8 death death NN cord-010119-t1x9gknd 1196 9 , , , cord-010119-t1x9gknd 1196 10 it -PRON- PRP cord-010119-t1x9gknd 1196 11 is be VBZ cord-010119-t1x9gknd 1196 12 also also RB cord-010119-t1x9gknd 1196 13 important important JJ cord-010119-t1x9gknd 1196 14 in in IN cord-010119-t1x9gknd 1196 15 the the DT cord-010119-t1x9gknd 1196 16 regulation regulation NN cord-010119-t1x9gknd 1196 17 of of IN cord-010119-t1x9gknd 1196 18 a a DT cord-010119-t1x9gknd 1196 19 healthy healthy JJ cord-010119-t1x9gknd 1196 20 immune immune JJ cord-010119-t1x9gknd 1196 21 response response NN cord-010119-t1x9gknd 1196 22 to to IN cord-010119-t1x9gknd 1196 23 injury injury NN cord-010119-t1x9gknd 1196 24 or or CC cord-010119-t1x9gknd 1196 25 disease disease NN cord-010119-t1x9gknd 1196 26 . . . cord-010119-t1x9gknd 1197 1 In in IN cord-010119-t1x9gknd 1197 2 the the DT cord-010119-t1x9gknd 1197 3 present present JJ cord-010119-t1x9gknd 1197 4 study study NN cord-010119-t1x9gknd 1197 5 we -PRON- PRP cord-010119-t1x9gknd 1197 6 investigated investigate VBD cord-010119-t1x9gknd 1197 7 changes change NNS cord-010119-t1x9gknd 1197 8 in in IN cord-010119-t1x9gknd 1197 9 hemoglobin hemoglobin NN cord-010119-t1x9gknd 1197 10 , , , cord-010119-t1x9gknd 1197 11 free free JJ cord-010119-t1x9gknd 1197 12 heme heme NN cord-010119-t1x9gknd 1197 13 , , , cord-010119-t1x9gknd 1197 14 and and CC cord-010119-t1x9gknd 1197 15 ORP ORP NNP cord-010119-t1x9gknd 1197 16 as as IN cord-010119-t1x9gknd 1197 17 red red JJ cord-010119-t1x9gknd 1197 18 blood blood NN cord-010119-t1x9gknd 1197 19 cells cell NNS cord-010119-t1x9gknd 1197 20 ( ( -LRB- cord-010119-t1x9gknd 1197 21 RBC RBC NNP cord-010119-t1x9gknd 1197 22 ) ) -RRB- cord-010119-t1x9gknd 1197 23 age age NN cord-010119-t1x9gknd 1197 24 and and CC cord-010119-t1x9gknd 1197 25 the the DT cord-010119-t1x9gknd 1197 26 effects effect NNS cord-010119-t1x9gknd 1197 27 of of IN cord-010119-t1x9gknd 1197 28 red red JJ cord-010119-t1x9gknd 1197 29 blood blood NN cord-010119-t1x9gknd 1197 30 cell cell NN cord-010119-t1x9gknd 1197 31 age age NN cord-010119-t1x9gknd 1197 32 on on IN cord-010119-t1x9gknd 1197 33 ICU ICU NNP cord-010119-t1x9gknd 1197 34 patient patient JJ cord-010119-t1x9gknd 1197 35 morbidity morbidity NN cord-010119-t1x9gknd 1197 36 and and CC cord-010119-t1x9gknd 1197 37 mortality mortality NN cord-010119-t1x9gknd 1197 38 . . . cord-010119-t1x9gknd 1198 1 Study Study NNP cord-010119-t1x9gknd 1198 2 Design Design NNP cord-010119-t1x9gknd 1198 3 / / SYM cord-010119-t1x9gknd 1198 4 Method method NN cord-010119-t1x9gknd 1198 5 : : : cord-010119-t1x9gknd 1199 1 120 120 CD cord-010119-t1x9gknd 1199 2 ICU ICU NNP cord-010119-t1x9gknd 1199 3 patients patient NNS cord-010119-t1x9gknd 1199 4 were be VBD cord-010119-t1x9gknd 1199 5 enrolled enrol VBN cord-010119-t1x9gknd 1199 6 in in IN cord-010119-t1x9gknd 1199 7 this this DT cord-010119-t1x9gknd 1199 8 prospective prospective JJ cord-010119-t1x9gknd 1199 9 observational observational JJ cord-010119-t1x9gknd 1199 10 trial trial NN cord-010119-t1x9gknd 1199 11 investigating investigate VBG cord-010119-t1x9gknd 1199 12 the the DT cord-010119-t1x9gknd 1199 13 effect effect NN cord-010119-t1x9gknd 1199 14 of of IN cord-010119-t1x9gknd 1199 15 transfused transfuse VBN cord-010119-t1x9gknd 1199 16 RBC RBC NNP cord-010119-t1x9gknd 1199 17 age age NN cord-010119-t1x9gknd 1199 18 on on IN cord-010119-t1x9gknd 1199 19 ICU ICU NNP cord-010119-t1x9gknd 1199 20 patient patient JJ cord-010119-t1x9gknd 1199 21 morbidity morbidity NN cord-010119-t1x9gknd 1199 22 and and CC cord-010119-t1x9gknd 1199 23 mortality mortality NN cord-010119-t1x9gknd 1199 24 . . . cord-010119-t1x9gknd 1200 1 All all DT cord-010119-t1x9gknd 1200 2 RBCs rbc NNS cord-010119-t1x9gknd 1200 3 were be VBD cord-010119-t1x9gknd 1200 4 pre pre JJ cord-010119-t1x9gknd 1200 5 - - JJ cord-010119-t1x9gknd 1200 6 storage storage JJ cord-010119-t1x9gknd 1200 7 leukoreduced leukoreduced NNP cord-010119-t1x9gknd 1200 8 and and CC cord-010119-t1x9gknd 1200 9 ABO ABO NNP cord-010119-t1x9gknd 1200 10 identical identical JJ cord-010119-t1x9gknd 1200 11 . . . cord-010119-t1x9gknd 1201 1 Citrated citrate VBN cord-010119-t1x9gknd 1201 2 blood blood NN cord-010119-t1x9gknd 1201 3 samples sample NNS cord-010119-t1x9gknd 1201 4 were be VBD cord-010119-t1x9gknd 1201 5 collected collect VBN cord-010119-t1x9gknd 1201 6 from from IN cord-010119-t1x9gknd 1201 7 each each DT cord-010119-t1x9gknd 1201 8 RBC RBC NNP cord-010119-t1x9gknd 1201 9 unit unit NN cord-010119-t1x9gknd 1201 10 prior prior RB cord-010119-t1x9gknd 1201 11 to to IN cord-010119-t1x9gknd 1201 12 issue issue NN cord-010119-t1x9gknd 1201 13 . . . cord-010119-t1x9gknd 1202 1 The the DT cord-010119-t1x9gknd 1202 2 RBC RBC NNP cord-010119-t1x9gknd 1202 3 supernatants supernatant NNS cord-010119-t1x9gknd 1202 4 were be VBD cord-010119-t1x9gknd 1202 5 tested test VBN cord-010119-t1x9gknd 1202 6 for for IN cord-010119-t1x9gknd 1202 7 free free JJ cord-010119-t1x9gknd 1202 8 hemoglobin/ hemoglobin/ ADD cord-010119-t1x9gknd 1202 9 heme heme NNP cord-010119-t1x9gknd 1202 10 and and CC cord-010119-t1x9gknd 1202 11 ORP ORP NNP cord-010119-t1x9gknd 1202 12 . . . cord-010119-t1x9gknd 1203 1 The the DT cord-010119-t1x9gknd 1203 2 patients patient NNS cord-010119-t1x9gknd 1203 3 were be VBD cord-010119-t1x9gknd 1203 4 followed follow VBN cord-010119-t1x9gknd 1203 5 prospectively prospectively RB cord-010119-t1x9gknd 1203 6 . . . cord-010119-t1x9gknd 1204 1 Results/ Results/ . cord-010119-t1x9gknd 1205 1 Finding finding NN cord-010119-t1x9gknd 1205 2 : : : cord-010119-t1x9gknd 1205 3 A a DT cord-010119-t1x9gknd 1205 4 total total NN cord-010119-t1x9gknd 1205 5 of of IN cord-010119-t1x9gknd 1205 6 426 426 CD cord-010119-t1x9gknd 1205 7 RBC RBC NNP cord-010119-t1x9gknd 1205 8 units unit NNS cord-010119-t1x9gknd 1205 9 were be VBD cord-010119-t1x9gknd 1205 10 transfused transfuse VBN cord-010119-t1x9gknd 1205 11 . . . cord-010119-t1x9gknd 1206 1 Patients Patients NNP cord-010119-t1x9gknd 1206 2 and and CC cord-010119-t1x9gknd 1206 3 RBC RBC NNP cord-010119-t1x9gknd 1206 4 characteristics characteristic NNS cord-010119-t1x9gknd 1206 5 are be VBP cord-010119-t1x9gknd 1206 6 shown show VBN cord-010119-t1x9gknd 1206 7 in in IN cord-010119-t1x9gknd 1206 8 the the DT cord-010119-t1x9gknd 1206 9 table table NN cord-010119-t1x9gknd 1206 10 . . . cord-010119-t1x9gknd 1207 1 Significant significant JJ cord-010119-t1x9gknd 1207 2 reductions reduction NNS cord-010119-t1x9gknd 1207 3 were be VBD cord-010119-t1x9gknd 1207 4 detected detect VBN cord-010119-t1x9gknd 1207 5 in in IN cord-010119-t1x9gknd 1207 6 ORP ORP NNP cord-010119-t1x9gknd 1207 7 values value NNS cord-010119-t1x9gknd 1207 8 over over IN cord-010119-t1x9gknd 1207 9 storage storage NN cord-010119-t1x9gknd 1207 10 duration duration NN cord-010119-t1x9gknd 1207 11 ( ( -LRB- cord-010119-t1x9gknd 1207 12 p<0.001 p<0.001 CD cord-010119-t1x9gknd 1207 13 ) ) -RRB- cord-010119-t1x9gknd 1207 14 . . . cord-010119-t1x9gknd 1208 1 Substantial substantial JJ cord-010119-t1x9gknd 1208 2 correlations correlation NNS cord-010119-t1x9gknd 1208 3 were be VBD cord-010119-t1x9gknd 1208 4 also also RB cord-010119-t1x9gknd 1208 5 found find VBN cord-010119-t1x9gknd 1208 6 between between IN cord-010119-t1x9gknd 1208 7 ORP ORP NNP cord-010119-t1x9gknd 1208 8 and and CC cord-010119-t1x9gknd 1208 9 free free JJ cord-010119-t1x9gknd 1208 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 1208 11 ( ( -LRB- cord-010119-t1x9gknd 1208 12 p<0.05 p<0.05 NNP cord-010119-t1x9gknd 1208 13 ) ) -RRB- cord-010119-t1x9gknd 1208 14 and and CC cord-010119-t1x9gknd 1208 15 ORP ORP NNP cord-010119-t1x9gknd 1208 16 and and CC cord-010119-t1x9gknd 1208 17 free free JJ cord-010119-t1x9gknd 1208 18 heme heme NNP cord-010119-t1x9gknd 1208 19 ( ( -LRB- cord-010119-t1x9gknd 1208 20 p<0.05 p<0.05 NNP cord-010119-t1x9gknd 1208 21 ) ) -RRB- cord-010119-t1x9gknd 1208 22 . . . cord-010119-t1x9gknd 1209 1 Interestingly interestingly RB cord-010119-t1x9gknd 1209 2 , , , cord-010119-t1x9gknd 1209 3 there there EX cord-010119-t1x9gknd 1209 4 was be VBD cord-010119-t1x9gknd 1209 5 a a DT cord-010119-t1x9gknd 1209 6 statistically statistically RB cord-010119-t1x9gknd 1209 7 significant significant JJ cord-010119-t1x9gknd 1209 8 difference difference NN cord-010119-t1x9gknd 1209 9 between between IN cord-010119-t1x9gknd 1209 10 the the DT cord-010119-t1x9gknd 1209 11 average average JJ cord-010119-t1x9gknd 1209 12 ORP ORP NNP cord-010119-t1x9gknd 1209 13 values value NNS cord-010119-t1x9gknd 1209 14 of of IN cord-010119-t1x9gknd 1209 15 the the DT cord-010119-t1x9gknd 1209 16 transfused transfuse VBN cord-010119-t1x9gknd 1209 17 RBC RBC NNP cord-010119-t1x9gknd 1209 18 in in IN cord-010119-t1x9gknd 1209 19 patients patient NNS cord-010119-t1x9gknd 1209 20 who who WP cord-010119-t1x9gknd 1209 21 developed develop VBD cord-010119-t1x9gknd 1209 22 infection infection NN cord-010119-t1x9gknd 1209 23 with with IN cord-010119-t1x9gknd 1209 24 higher high JJR cord-010119-t1x9gknd 1209 25 ORP ORP NNP cord-010119-t1x9gknd 1209 26 values value NNS cord-010119-t1x9gknd 1209 27 measured measure VBN cord-010119-t1x9gknd 1209 28 in in IN cord-010119-t1x9gknd 1209 29 RBC RBC NNP cord-010119-t1x9gknd 1209 30 units unit NNS cord-010119-t1x9gknd 1209 31 given give VBN cord-010119-t1x9gknd 1209 32 to to IN cord-010119-t1x9gknd 1209 33 patients patient NNS cord-010119-t1x9gknd 1209 34 who who WP cord-010119-t1x9gknd 1209 35 developed develop VBD cord-010119-t1x9gknd 1209 36 post post JJ cord-010119-t1x9gknd 1209 37 - - JJ cord-010119-t1x9gknd 1209 38 transfusion transfusion JJ cord-010119-t1x9gknd 1209 39 infections infection NNS cord-010119-t1x9gknd 1209 40 132 132 CD cord-010119-t1x9gknd 1209 41 6 6 CD cord-010119-t1x9gknd 1209 42 10 10 CD cord-010119-t1x9gknd 1209 43 vs vs IN cord-010119-t1x9gknd 1209 44 127 127 CD cord-010119-t1x9gknd 1209 45 6 6 CD cord-010119-t1x9gknd 1209 46 13 13 CD cord-010119-t1x9gknd 1209 47 ( ( -LRB- cord-010119-t1x9gknd 1209 48 p<0.05 p<0.05 CD cord-010119-t1x9gknd 1209 49 ) ) -RRB- cord-010119-t1x9gknd 1209 50 . . . cord-010119-t1x9gknd 1210 1 No no DT cord-010119-t1x9gknd 1210 2 significant significant JJ cord-010119-t1x9gknd 1210 3 differences difference NNS cord-010119-t1x9gknd 1210 4 were be VBD cord-010119-t1x9gknd 1210 5 observed observe VBN cord-010119-t1x9gknd 1210 6 between between IN cord-010119-t1x9gknd 1210 7 ORP ORP NNP cord-010119-t1x9gknd 1210 8 and and CC cord-010119-t1x9gknd 1210 9 patient patient JJ cord-010119-t1x9gknd 1210 10 mortality mortality NN cord-010119-t1x9gknd 1210 11 , , , cord-010119-t1x9gknd 1210 12 hospital hospital NN cord-010119-t1x9gknd 1210 13 / / SYM cord-010119-t1x9gknd 1210 14 ICU ICU NNP cord-010119-t1x9gknd 1210 15 days day NNS cord-010119-t1x9gknd 1210 16 , , , cord-010119-t1x9gknd 1210 17 or or CC cord-010119-t1x9gknd 1210 18 thrombosis thrombosis NN cord-010119-t1x9gknd 1210 19 . . . cord-010119-t1x9gknd 1211 1 Also also RB cord-010119-t1x9gknd 1211 2 , , , cord-010119-t1x9gknd 1211 3 no no DT cord-010119-t1x9gknd 1211 4 correlations correlation NNS cord-010119-t1x9gknd 1211 5 were be VBD cord-010119-t1x9gknd 1211 6 detected detect VBN cord-010119-t1x9gknd 1211 7 between between IN cord-010119-t1x9gknd 1211 8 free free JJ cord-010119-t1x9gknd 1211 9 heme heme NN cord-010119-t1x9gknd 1211 10 / / SYM cord-010119-t1x9gknd 1211 11 hemoglobin hemoglobin NN cord-010119-t1x9gknd 1211 12 or or CC cord-010119-t1x9gknd 1211 13 RBC RBC NNP cord-010119-t1x9gknd 1211 14 age age NN cord-010119-t1x9gknd 1211 15 and and CC cord-010119-t1x9gknd 1211 16 infection infection NN cord-010119-t1x9gknd 1211 17 development development NN cord-010119-t1x9gknd 1211 18 . . . cord-010119-t1x9gknd 1212 1 Conclusion conclusion NN cord-010119-t1x9gknd 1212 2 : : : cord-010119-t1x9gknd 1213 1 These these DT cord-010119-t1x9gknd 1213 2 data datum NNS cord-010119-t1x9gknd 1213 3 demonstrate demonstrate VBP cord-010119-t1x9gknd 1213 4 that that IN cord-010119-t1x9gknd 1213 5 older old JJR cord-010119-t1x9gknd 1213 6 blood blood NN cord-010119-t1x9gknd 1213 7 has have VBZ cord-010119-t1x9gknd 1213 8 lower low JJR cord-010119-t1x9gknd 1213 9 ORP ORP NNP cord-010119-t1x9gknd 1213 10 values value NNS cord-010119-t1x9gknd 1213 11 as as RB cord-010119-t1x9gknd 1213 12 well well RB cord-010119-t1x9gknd 1213 13 as as IN cord-010119-t1x9gknd 1213 14 increased increase VBN cord-010119-t1x9gknd 1213 15 free free JJ cord-010119-t1x9gknd 1213 16 heme heme NN cord-010119-t1x9gknd 1213 17 / / SYM cord-010119-t1x9gknd 1213 18 hemoglobin hemoglobin NN cord-010119-t1x9gknd 1213 19 . . . cord-010119-t1x9gknd 1214 1 There there EX cord-010119-t1x9gknd 1214 2 were be VBD cord-010119-t1x9gknd 1214 3 no no DT cord-010119-t1x9gknd 1214 4 differences difference NNS cord-010119-t1x9gknd 1214 5 in in IN cord-010119-t1x9gknd 1214 6 ORP ORP NNP cord-010119-t1x9gknd 1214 7 values value NNS cord-010119-t1x9gknd 1214 8 between between IN cord-010119-t1x9gknd 1214 9 the the DT cord-010119-t1x9gknd 1214 10 different different JJ cord-010119-t1x9gknd 1214 11 blood blood NN cord-010119-t1x9gknd 1214 12 groups group NNS cord-010119-t1x9gknd 1214 13 once once RB cord-010119-t1x9gknd 1214 14 RBC RBC NNP cord-010119-t1x9gknd 1214 15 age age NN cord-010119-t1x9gknd 1214 16 was be VBD cord-010119-t1x9gknd 1214 17 controlled control VBN cord-010119-t1x9gknd 1214 18 for for IN cord-010119-t1x9gknd 1214 19 and and CC cord-010119-t1x9gknd 1214 20 there there EX cord-010119-t1x9gknd 1214 21 were be VBD cord-010119-t1x9gknd 1214 22 no no DT cord-010119-t1x9gknd 1214 23 statistically statistically RB cord-010119-t1x9gknd 1214 24 significant significant JJ cord-010119-t1x9gknd 1214 25 differences difference NNS cord-010119-t1x9gknd 1214 26 in in IN cord-010119-t1x9gknd 1214 27 patient patient JJ cord-010119-t1x9gknd 1214 28 mortality mortality NN cord-010119-t1x9gknd 1214 29 associated associate VBN cord-010119-t1x9gknd 1214 30 with with IN cord-010119-t1x9gknd 1214 31 ORP ORP NNP cord-010119-t1x9gknd 1214 32 , , , cord-010119-t1x9gknd 1214 33 free free JJ cord-010119-t1x9gknd 1214 34 heme heme NN cord-010119-t1x9gknd 1214 35 / / SYM cord-010119-t1x9gknd 1214 36 hemoglobin hemoglobin NN cord-010119-t1x9gknd 1214 37 , , , cord-010119-t1x9gknd 1214 38 or or CC cord-010119-t1x9gknd 1214 39 RBC RBC NNP cord-010119-t1x9gknd 1214 40 age age NN cord-010119-t1x9gknd 1214 41 . . . cord-010119-t1x9gknd 1215 1 The the DT cord-010119-t1x9gknd 1215 2 decreased decrease VBN cord-010119-t1x9gknd 1215 3 ORP ORP NNP cord-010119-t1x9gknd 1215 4 values value NNS cord-010119-t1x9gknd 1215 5 observed observe VBN cord-010119-t1x9gknd 1215 6 in in IN cord-010119-t1x9gknd 1215 7 the the DT cord-010119-t1x9gknd 1215 8 older old JJR cord-010119-t1x9gknd 1215 9 blood blood NN cord-010119-t1x9gknd 1215 10 are be VBP cord-010119-t1x9gknd 1215 11 likely likely RB cord-010119-t1x9gknd 1215 12 attributable attributable JJ cord-010119-t1x9gknd 1215 13 to to IN cord-010119-t1x9gknd 1215 14 the the DT cord-010119-t1x9gknd 1215 15 " " `` cord-010119-t1x9gknd 1215 16 storage storage NN cord-010119-t1x9gknd 1215 17 lesion lesion NN cord-010119-t1x9gknd 1215 18 " " '' cord-010119-t1x9gknd 1215 19 . . . cord-010119-t1x9gknd 1216 1 Higher high JJR cord-010119-t1x9gknd 1216 2 transfused transfuse VBN cord-010119-t1x9gknd 1216 3 RBC RBC NNP cord-010119-t1x9gknd 1216 4 ORP ORP NNP cord-010119-t1x9gknd 1216 5 values value NNS cord-010119-t1x9gknd 1216 6 were be VBD cord-010119-t1x9gknd 1216 7 associated associate VBN cord-010119-t1x9gknd 1216 8 with with IN cord-010119-t1x9gknd 1216 9 subsequent subsequent JJ cord-010119-t1x9gknd 1216 10 development development NN cord-010119-t1x9gknd 1216 11 of of IN cord-010119-t1x9gknd 1216 12 infection infection NN cord-010119-t1x9gknd 1216 13 , , , cord-010119-t1x9gknd 1216 14 and and CC cord-010119-t1x9gknd 1216 15 younger young JJR cord-010119-t1x9gknd 1216 16 RBCs rbc NNS cord-010119-t1x9gknd 1216 17 were be VBD cord-010119-t1x9gknd 1216 18 found find VBN cord-010119-t1x9gknd 1216 19 to to TO cord-010119-t1x9gknd 1216 20 have have VB cord-010119-t1x9gknd 1216 21 higher high JJR cord-010119-t1x9gknd 1216 22 ORP ORP NNP cord-010119-t1x9gknd 1216 23 values value NNS cord-010119-t1x9gknd 1216 24 . . . cord-010119-t1x9gknd 1217 1 Thus thus RB cord-010119-t1x9gknd 1217 2 , , , cord-010119-t1x9gknd 1217 3 this this DT cord-010119-t1x9gknd 1217 4 data data NN cord-010119-t1x9gknd 1217 5 supports support VBZ cord-010119-t1x9gknd 1217 6 that that IN cord-010119-t1x9gknd 1217 7 young young JJ cord-010119-t1x9gknd 1217 8 / / SYM cord-010119-t1x9gknd 1217 9 fresher fresh JJR cord-010119-t1x9gknd 1217 10 blood blood NN cord-010119-t1x9gknd 1217 11 may may MD cord-010119-t1x9gknd 1217 12 predispose predispose VB cord-010119-t1x9gknd 1217 13 to to IN cord-010119-t1x9gknd 1217 14 subsequent subsequent JJ cord-010119-t1x9gknd 1217 15 development development NN cord-010119-t1x9gknd 1217 16 of of IN cord-010119-t1x9gknd 1217 17 infection infection NN cord-010119-t1x9gknd 1217 18 in in IN cord-010119-t1x9gknd 1217 19 critically critically RB cord-010119-t1x9gknd 1217 20 ill ill JJ cord-010119-t1x9gknd 1217 21 patients patient NNS cord-010119-t1x9gknd 1217 22 . . . cord-010119-t1x9gknd 1218 1 Further further JJ cord-010119-t1x9gknd 1218 2 studies study NNS cord-010119-t1x9gknd 1218 3 are be VBP cord-010119-t1x9gknd 1218 4 needed need VBN cord-010119-t1x9gknd 1218 5 . . . cord-010119-t1x9gknd 1219 1 Background Background NNP cord-010119-t1x9gknd 1219 2 / / SYM cord-010119-t1x9gknd 1219 3 Case Case NNP cord-010119-t1x9gknd 1219 4 Studies Studies NNPS cord-010119-t1x9gknd 1220 1 : : : cord-010119-t1x9gknd 1220 2 No no DT cord-010119-t1x9gknd 1220 3 randomized randomized JJ cord-010119-t1x9gknd 1220 4 trials trial NNS cord-010119-t1x9gknd 1220 5 in in IN cord-010119-t1x9gknd 1220 6 humans human NNS cord-010119-t1x9gknd 1220 7 have have VBP cord-010119-t1x9gknd 1220 8 addressed address VBN cord-010119-t1x9gknd 1220 9 whether whether IN cord-010119-t1x9gknd 1220 10 only only JJ cord-010119-t1x9gknd 1220 11 exposure exposure NN cord-010119-t1x9gknd 1220 12 to to IN cord-010119-t1x9gknd 1220 13 red red JJ cord-010119-t1x9gknd 1220 14 blood blood NN cord-010119-t1x9gknd 1220 15 cells cell NNS cord-010119-t1x9gknd 1220 16 ( ( -LRB- cord-010119-t1x9gknd 1220 17 RBCs rbc NNS cord-010119-t1x9gknd 1220 18 ) ) -RRB- cord-010119-t1x9gknd 1220 19 that that WDT cord-010119-t1x9gknd 1220 20 have have VBP cord-010119-t1x9gknd 1220 21 been be VBN cord-010119-t1x9gknd 1220 22 stored store VBN cord-010119-t1x9gknd 1220 23 for for IN cord-010119-t1x9gknd 1220 24 a a DT cord-010119-t1x9gknd 1220 25 long long JJ cord-010119-t1x9gknd 1220 26 time time NN cord-010119-t1x9gknd 1220 27 is be VBZ cord-010119-t1x9gknd 1220 28 associated associate VBN cord-010119-t1x9gknd 1220 29 with with IN cord-010119-t1x9gknd 1220 30 harm harm NN cord-010119-t1x9gknd 1220 31 . . . cord-010119-t1x9gknd 1221 1 We -PRON- PRP cord-010119-t1x9gknd 1221 2 explore explore VBP cord-010119-t1x9gknd 1221 3 the the DT cord-010119-t1x9gknd 1221 4 effect effect NN cord-010119-t1x9gknd 1221 5 on on IN cord-010119-t1x9gknd 1221 6 inhospital inhospital JJ cord-010119-t1x9gknd 1221 7 mortality mortality NN cord-010119-t1x9gknd 1221 8 of of IN cord-010119-t1x9gknd 1221 9 transfusing transfuse VBG cord-010119-t1x9gknd 1221 10 RBCs rbc NNS cord-010119-t1x9gknd 1221 11 stored store VBD cord-010119-t1x9gknd 1221 12 for for IN cord-010119-t1x9gknd 1221 13 more more JJR cord-010119-t1x9gknd 1221 14 than than IN cord-010119-t1x9gknd 1221 15 35 35 CD cord-010119-t1x9gknd 1221 16 days day NNS cord-010119-t1x9gknd 1221 17 compared compare VBN cord-010119-t1x9gknd 1221 18 to to IN cord-010119-t1x9gknd 1221 19 RBCs rbc NNS cord-010119-t1x9gknd 1221 20 stored store VBN cord-010119-t1x9gknd 1221 21 for for IN cord-010119-t1x9gknd 1221 22 7 7 CD cord-010119-t1x9gknd 1221 23 days day NNS cord-010119-t1x9gknd 1221 24 or or CC cord-010119-t1x9gknd 1221 25 less less JJR cord-010119-t1x9gknd 1221 26 . . . cord-010119-t1x9gknd 1222 1 Study Study NNP cord-010119-t1x9gknd 1222 2 Design Design NNP cord-010119-t1x9gknd 1222 3 / / SYM cord-010119-t1x9gknd 1222 4 Method method NN cord-010119-t1x9gknd 1222 5 : : : cord-010119-t1x9gknd 1223 1 Data datum NNS cord-010119-t1x9gknd 1223 2 from from IN cord-010119-t1x9gknd 1223 3 a a DT cord-010119-t1x9gknd 1223 4 multi multi JJ cord-010119-t1x9gknd 1223 5 - - JJ cord-010119-t1x9gknd 1223 6 national national JJ cord-010119-t1x9gknd 1223 7 randomized randomize VBN cord-010119-t1x9gknd 1223 8 controlled control VBN cord-010119-t1x9gknd 1223 9 trial trial NN cord-010119-t1x9gknd 1223 10 were be VBD cord-010119-t1x9gknd 1223 11 used use VBN cord-010119-t1x9gknd 1223 12 for for IN cord-010119-t1x9gknd 1223 13 this this DT cord-010119-t1x9gknd 1223 14 exploratory exploratory JJ cord-010119-t1x9gknd 1223 15 analysis analysis NN cord-010119-t1x9gknd 1223 16 . . . cord-010119-t1x9gknd 1224 1 The the DT cord-010119-t1x9gknd 1224 2 patients patient NNS cord-010119-t1x9gknd 1224 3 were be VBD cord-010119-t1x9gknd 1224 4 hospitalized hospitalize VBN cord-010119-t1x9gknd 1224 5 adults adult NNS cord-010119-t1x9gknd 1224 6 who who WP cord-010119-t1x9gknd 1224 7 required require VBD cord-010119-t1x9gknd 1224 8 transfusions transfusion NNS cord-010119-t1x9gknd 1224 9 and and CC cord-010119-t1x9gknd 1224 10 were be VBD cord-010119-t1x9gknd 1224 11 randomly randomly RB cord-010119-t1x9gknd 1224 12 allocated allocate VBN cord-010119-t1x9gknd 1224 13 to to TO cord-010119-t1x9gknd 1224 14 receive receive VB cord-010119-t1x9gknd 1224 15 the the DT cord-010119-t1x9gknd 1224 16 freshest fresh JJS cord-010119-t1x9gknd 1224 17 RBCs rbc NNS cord-010119-t1x9gknd 1224 18 in in IN cord-010119-t1x9gknd 1224 19 inventory inventory NN cord-010119-t1x9gknd 1224 20 or or CC cord-010119-t1x9gknd 1224 21 the the DT cord-010119-t1x9gknd 1224 22 oldest old JJS cord-010119-t1x9gknd 1224 23 ( ( -LRB- cord-010119-t1x9gknd 1224 24 standard standard JJ cord-010119-t1x9gknd 1224 25 issue issue NN cord-010119-t1x9gknd 1224 26 ) ) -RRB- cord-010119-t1x9gknd 1224 27 RBCs rbc NNS cord-010119-t1x9gknd 1224 28 providing provide VBG cord-010119-t1x9gknd 1224 29 a a DT cord-010119-t1x9gknd 1224 30 large large JJ cord-010119-t1x9gknd 1224 31 cohort cohort NN cord-010119-t1x9gknd 1224 32 of of IN cord-010119-t1x9gknd 1224 33 patients patient NNS cord-010119-t1x9gknd 1224 34 receiving receive VBG cord-010119-t1x9gknd 1224 35 RBCs rbc NNS cord-010119-t1x9gknd 1224 36 with with IN cord-010119-t1x9gknd 1224 37 storage storage NN cord-010119-t1x9gknd 1224 38 durations duration NNS cord-010119-t1x9gknd 1224 39 along along IN cord-010119-t1x9gknd 1224 40 the the DT cord-010119-t1x9gknd 1224 41 entire entire JJ cord-010119-t1x9gknd 1224 42 RBC RBC NNP cord-010119-t1x9gknd 1224 43 storage storage NN cord-010119-t1x9gknd 1224 44 continuum continuum NN cord-010119-t1x9gknd 1224 45 of of IN cord-010119-t1x9gknd 1224 46 1 1 CD cord-010119-t1x9gknd 1224 47 to to TO cord-010119-t1x9gknd 1224 48 42 42 CD cord-010119-t1x9gknd 1224 49 days day NNS cord-010119-t1x9gknd 1224 50 . . . cord-010119-t1x9gknd 1225 1 Using use VBG cord-010119-t1x9gknd 1225 2 a a DT cord-010119-t1x9gknd 1225 3 time time NN cord-010119-t1x9gknd 1225 4 dependent dependent JJ cord-010119-t1x9gknd 1225 5 variable variable JJ cord-010119-t1x9gknd 1225 6 patient patient NN cord-010119-t1x9gknd 1225 7 exposure exposure NN cord-010119-t1x9gknd 1225 8 was be VBD cord-010119-t1x9gknd 1225 9 defined define VBN cord-010119-t1x9gknd 1225 10 by by IN cord-010119-t1x9gknd 1225 11 the the DT cord-010119-t1x9gknd 1225 12 maximum maximum JJ cord-010119-t1x9gknd 1225 13 storage storage NN cord-010119-t1x9gknd 1225 14 duration duration NN cord-010119-t1x9gknd 1225 15 of of IN cord-010119-t1x9gknd 1225 16 RBCs rbc NNS cord-010119-t1x9gknd 1225 17 received receive VBD cord-010119-t1x9gknd 1225 18 . . . cord-010119-t1x9gknd 1226 1 This this DT cord-010119-t1x9gknd 1226 2 was be VBD cord-010119-t1x9gknd 1226 3 then then RB cord-010119-t1x9gknd 1226 4 used use VBN cord-010119-t1x9gknd 1226 5 to to TO cord-010119-t1x9gknd 1226 6 classify classify VB cord-010119-t1x9gknd 1226 7 individuals individual NNS cord-010119-t1x9gknd 1226 8 on on IN cord-010119-t1x9gknd 1226 9 each each DT cord-010119-t1x9gknd 1226 10 day day NN cord-010119-t1x9gknd 1226 11 of of IN cord-010119-t1x9gknd 1226 12 hospitalization hospitalization NN cord-010119-t1x9gknd 1226 13 into into IN cord-010119-t1x9gknd 1226 14 one one CD cord-010119-t1x9gknd 1226 15 of of IN cord-010119-t1x9gknd 1226 16 three three CD cord-010119-t1x9gknd 1226 17 mutually mutually RB cord-010119-t1x9gknd 1226 18 exclusive exclusive JJ cord-010119-t1x9gknd 1226 19 exposure exposure NN cord-010119-t1x9gknd 1226 20 categories category NNS cord-010119-t1x9gknd 1226 21 : : : cord-010119-t1x9gknd 1226 22 freshest freshest RBS cord-010119-t1x9gknd 1226 23 ( ( -LRB- cord-010119-t1x9gknd 1226 24 exclusively exclusively RB cord-010119-t1x9gknd 1226 25 exposed expose VBN cord-010119-t1x9gknd 1226 26 to to IN cord-010119-t1x9gknd 1226 27 RBCs rbc NNS cord-010119-t1x9gknd 1226 28 less less JJR cord-010119-t1x9gknd 1226 29 than than IN cord-010119-t1x9gknd 1226 30 or or CC cord-010119-t1x9gknd 1226 31 equal equal JJ cord-010119-t1x9gknd 1226 32 to to IN cord-010119-t1x9gknd 1226 33 7 7 CD cord-010119-t1x9gknd 1226 34 days day NNS cord-010119-t1x9gknd 1226 35 storage storage NN cord-010119-t1x9gknd 1226 36 duration duration NN cord-010119-t1x9gknd 1226 37 -reference -reference NN cord-010119-t1x9gknd 1226 38 group group NN cord-010119-t1x9gknd 1226 39 ) ) -RRB- cord-010119-t1x9gknd 1226 40 , , , cord-010119-t1x9gknd 1226 41 medium medium NN cord-010119-t1x9gknd 1226 42 age age NN cord-010119-t1x9gknd 1226 43 ( ( -LRB- cord-010119-t1x9gknd 1226 44 at at IN cord-010119-t1x9gknd 1226 45 least least JJS cord-010119-t1x9gknd 1226 46 1 1 CD cord-010119-t1x9gknd 1226 47 RBC RBC NNP cord-010119-t1x9gknd 1226 48 of of IN cord-010119-t1x9gknd 1226 49 8 8 CD cord-010119-t1x9gknd 1226 50 - - SYM cord-010119-t1x9gknd 1226 51 35 35 CD cord-010119-t1x9gknd 1226 52 days day NNS cord-010119-t1x9gknd 1226 53 storage storage NN cord-010119-t1x9gknd 1226 54 ) ) -RRB- cord-010119-t1x9gknd 1226 55 , , , cord-010119-t1x9gknd 1226 56 and and CC cord-010119-t1x9gknd 1226 57 oldest old JJS cord-010119-t1x9gknd 1226 58 ( ( -LRB- cord-010119-t1x9gknd 1226 59 at at IN cord-010119-t1x9gknd 1226 60 least least JJS cord-010119-t1x9gknd 1226 61 1 1 CD cord-010119-t1x9gknd 1226 62 RBC RBC NNP cord-010119-t1x9gknd 1226 63 greater great JJR cord-010119-t1x9gknd 1226 64 than than IN cord-010119-t1x9gknd 1226 65 35 35 CD cord-010119-t1x9gknd 1226 66 days day NNS cord-010119-t1x9gknd 1226 67 storage storage NN cord-010119-t1x9gknd 1226 68 ) ) -RRB- cord-010119-t1x9gknd 1226 69 . . . cord-010119-t1x9gknd 1227 1 The the DT cord-010119-t1x9gknd 1227 2 primary primary JJ cord-010119-t1x9gknd 1227 3 outcome outcome NN cord-010119-t1x9gknd 1227 4 was be VBD cord-010119-t1x9gknd 1227 5 all all RB cord-010119-t1x9gknd 1227 6 - - HYPH cord-010119-t1x9gknd 1227 7 cause cause NN cord-010119-t1x9gknd 1227 8 in in IN cord-010119-t1x9gknd 1227 9 - - HYPH cord-010119-t1x9gknd 1227 10 hospital hospital NN cord-010119-t1x9gknd 1227 11 mortality mortality NN cord-010119-t1x9gknd 1227 12 . . . cord-010119-t1x9gknd 1228 1 Cause cause NN cord-010119-t1x9gknd 1228 2 - - HYPH cord-010119-t1x9gknd 1228 3 specific specific JJ cord-010119-t1x9gknd 1228 4 Cox Cox NNP cord-010119-t1x9gknd 1228 5 regression regression NN cord-010119-t1x9gknd 1228 6 models model NNS cord-010119-t1x9gknd 1228 7 of of IN cord-010119-t1x9gknd 1228 8 in in IN cord-010119-t1x9gknd 1228 9 - - HYPH cord-010119-t1x9gknd 1228 10 hospital hospital NN cord-010119-t1x9gknd 1228 11 death death NN cord-010119-t1x9gknd 1228 12 assessed assess VBD cord-010119-t1x9gknd 1228 13 the the DT cord-010119-t1x9gknd 1228 14 effect effect NN cord-010119-t1x9gknd 1228 15 of of IN cord-010119-t1x9gknd 1228 16 exposure exposure NN cord-010119-t1x9gknd 1228 17 of of IN cord-010119-t1x9gknd 1228 18 RBCs rbc NNS cord-010119-t1x9gknd 1228 19 in in IN cord-010119-t1x9gknd 1228 20 each each DT cord-010119-t1x9gknd 1228 21 category category NN cord-010119-t1x9gknd 1228 22 to to IN cord-010119-t1x9gknd 1228 23 exclusive exclusive JJ cord-010119-t1x9gknd 1228 24 exposure exposure NN cord-010119-t1x9gknd 1228 25 to to IN cord-010119-t1x9gknd 1228 26 RBCs rbc NNS cord-010119-t1x9gknd 1228 27 stored store VBN cord-010119-t1x9gknd 1228 28 for for IN cord-010119-t1x9gknd 1228 29 7 7 CD cord-010119-t1x9gknd 1228 30 days day NNS cord-010119-t1x9gknd 1228 31 or or CC cord-010119-t1x9gknd 1228 32 less less JJR cord-010119-t1x9gknd 1228 33 . . . cord-010119-t1x9gknd 1229 1 The the DT cord-010119-t1x9gknd 1229 2 effects effect NNS cord-010119-t1x9gknd 1229 3 of of IN cord-010119-t1x9gknd 1229 4 fixed fix VBN cord-010119-t1x9gknd 1229 5 and and CC cord-010119-t1x9gknd 1229 6 time time NN cord-010119-t1x9gknd 1229 7 - - HYPH cord-010119-t1x9gknd 1229 8 dependent dependent JJ cord-010119-t1x9gknd 1229 9 confounders confounder NNS cord-010119-t1x9gknd 1229 10 were be VBD cord-010119-t1x9gknd 1229 11 dealt deal VBN cord-010119-t1x9gknd 1229 12 with with IN cord-010119-t1x9gknd 1229 13 through through IN cord-010119-t1x9gknd 1229 14 stratification stratification NN cord-010119-t1x9gknd 1229 15 and and CC cord-010119-t1x9gknd 1229 16 regression regression NN cord-010119-t1x9gknd 1229 17 . . . cord-010119-t1x9gknd 1230 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 1230 2 analyses analysis NNS cord-010119-t1x9gknd 1230 3 were be VBD cord-010119-t1x9gknd 1230 4 conducted conduct VBN cord-010119-t1x9gknd 1230 5 with with IN cord-010119-t1x9gknd 1230 6 a a DT cord-010119-t1x9gknd 1230 7 ) ) -RRB- cord-010119-t1x9gknd 1230 8 weekly weekly JJ cord-010119-t1x9gknd 1230 9 partition partition NN cord-010119-t1x9gknd 1230 10 with with IN cord-010119-t1x9gknd 1230 11 cut cut NN cord-010119-t1x9gknd 1230 12 - - HYPH cord-010119-t1x9gknd 1230 13 points point NNS cord-010119-t1x9gknd 1230 14 every every DT cord-010119-t1x9gknd 1230 15 7 7 CD cord-010119-t1x9gknd 1230 16 days day NNS cord-010119-t1x9gknd 1230 17 , , , cord-010119-t1x9gknd 1230 18 and and CC cord-010119-t1x9gknd 1230 19 b b LS cord-010119-t1x9gknd 1230 20 ) ) -RRB- cord-010119-t1x9gknd 1230 21 a a DT cord-010119-t1x9gknd 1230 22 finer fine JJR cord-010119-t1x9gknd 1230 23 partition partition NN cord-010119-t1x9gknd 1230 24 using use VBG cord-010119-t1x9gknd 1230 25 cut cut VBN cord-010119-t1x9gknd 1230 26 - - HYPH cord-010119-t1x9gknd 1230 27 points point NNS cord-010119-t1x9gknd 1230 28 every every DT cord-010119-t1x9gknd 1230 29 3 3 CD cord-010119-t1x9gknd 1230 30 days day NNS cord-010119-t1x9gknd 1230 31 . . . cord-010119-t1x9gknd 1231 1 Results result NNS cord-010119-t1x9gknd 1232 1 /Finding /finde VBG cord-010119-t1x9gknd 1232 2 : : : cord-010119-t1x9gknd 1232 3 24,726 24,726 CD cord-010119-t1x9gknd 1232 4 patients patient NNS cord-010119-t1x9gknd 1232 5 receiving receive VBG cord-010119-t1x9gknd 1232 6 90,530 90,530 CD cord-010119-t1x9gknd 1232 7 RBCs rbc NNS cord-010119-t1x9gknd 1232 8 were be VBD cord-010119-t1x9gknd 1232 9 included include VBN cord-010119-t1x9gknd 1232 10 in in IN cord-010119-t1x9gknd 1232 11 the the DT cord-010119-t1x9gknd 1232 12 analysis analysis NN cord-010119-t1x9gknd 1232 13 . . . cord-010119-t1x9gknd 1233 1 Exposure exposure NN cord-010119-t1x9gknd 1233 2 to to IN cord-010119-t1x9gknd 1233 3 RBCs rbc NNS cord-010119-t1x9gknd 1233 4 stored store VBN cord-010119-t1x9gknd 1233 5 for for IN cord-010119-t1x9gknd 1233 6 more more JJR cord-010119-t1x9gknd 1233 7 than than IN cord-010119-t1x9gknd 1233 8 35 35 CD cord-010119-t1x9gknd 1233 9 days day NNS cord-010119-t1x9gknd 1233 10 was be VBD cord-010119-t1x9gknd 1233 11 not not RB cord-010119-t1x9gknd 1233 12 associated associate VBN cord-010119-t1x9gknd 1233 13 with with IN cord-010119-t1x9gknd 1233 14 increased increase VBN cord-010119-t1x9gknd 1233 15 risk risk NN cord-010119-t1x9gknd 1233 16 of of IN cord-010119-t1x9gknd 1233 17 in in IN cord-010119-t1x9gknd 1233 18 - - HYPH cord-010119-t1x9gknd 1233 19 hospital hospital NN cord-010119-t1x9gknd 1233 20 death death NN cord-010119-t1x9gknd 1233 21 compared compare VBN cord-010119-t1x9gknd 1233 22 with with IN cord-010119-t1x9gknd 1233 23 exposure exposure NN cord-010119-t1x9gknd 1233 24 exclusively exclusively RB cord-010119-t1x9gknd 1233 25 to to IN cord-010119-t1x9gknd 1233 26 the the DT cord-010119-t1x9gknd 1233 27 freshest fresh JJS cord-010119-t1x9gknd 1233 28 RBC RBC NNP cord-010119-t1x9gknd 1233 29 units unit NNS cord-010119-t1x9gknd 1233 30 ( ( -LRB- cord-010119-t1x9gknd 1233 31 stored store VBN cord-010119-t1x9gknd 1233 32 for for IN cord-010119-t1x9gknd 1233 33 7 7 CD cord-010119-t1x9gknd 1233 34 days day NNS cord-010119-t1x9gknd 1233 35 or or CC cord-010119-t1x9gknd 1233 36 less less JJR cord-010119-t1x9gknd 1233 37 ) ) -RRB- cord-010119-t1x9gknd 1233 38 after after IN cord-010119-t1x9gknd 1233 39 adjusting adjust VBG cord-010119-t1x9gknd 1233 40 for for IN cord-010119-t1x9gknd 1233 41 several several JJ cord-010119-t1x9gknd 1233 42 fixed fix VBN cord-010119-t1x9gknd 1233 43 and and CC cord-010119-t1x9gknd 1233 44 time time NN cord-010119-t1x9gknd 1233 45 - - HYPH cord-010119-t1x9gknd 1233 46 dependent dependent JJ cord-010119-t1x9gknd 1233 47 potential potential JJ cord-010119-t1x9gknd 1233 48 confounders confounder NNS cord-010119-t1x9gknd 1233 49 ( ( -LRB- cord-010119-t1x9gknd 1233 50 HR hr NN cord-010119-t1x9gknd 1233 51 5 5 CD cord-010119-t1x9gknd 1233 52 0.91 0.91 CD cord-010119-t1x9gknd 1233 53 ; ; : cord-010119-t1x9gknd 1233 54 95 95 CD cord-010119-t1x9gknd 1233 55 % % NN cord-010119-t1x9gknd 1233 56 CI ci NN cord-010119-t1x9gknd 1233 57 : : : cord-010119-t1x9gknd 1233 58 0.72 0.72 CD cord-010119-t1x9gknd 1233 59 , , , cord-010119-t1x9gknd 1233 60 1.14 1.14 CD cord-010119-t1x9gknd 1233 61 ; ; : cord-010119-t1x9gknd 1233 62 p p NN cord-010119-t1x9gknd 1233 63 5 5 CD cord-010119-t1x9gknd 1233 64 0.400 0.400 CD cord-010119-t1x9gknd 1233 65 ) ) -RRB- cord-010119-t1x9gknd 1233 66 . . . cord-010119-t1x9gknd 1234 1 Exposure exposure NN cord-010119-t1x9gknd 1234 2 to to IN cord-010119-t1x9gknd 1234 3 blood blood NN cord-010119-t1x9gknd 1234 4 stored store VBN cord-010119-t1x9gknd 1234 5 for for IN cord-010119-t1x9gknd 1234 6 at at RB cord-010119-t1x9gknd 1234 7 most most JJS cord-010119-t1x9gknd 1234 8 8 8 CD cord-010119-t1x9gknd 1234 9 - - SYM cord-010119-t1x9gknd 1234 10 35 35 CD cord-010119-t1x9gknd 1234 11 days day NNS cord-010119-t1x9gknd 1234 12 yielded yield VBD cord-010119-t1x9gknd 1234 13 a a DT cord-010119-t1x9gknd 1234 14 similar similar JJ cord-010119-t1x9gknd 1234 15 hazard hazard NN cord-010119-t1x9gknd 1234 16 ratio ratio NN cord-010119-t1x9gknd 1234 17 ( ( -LRB- cord-010119-t1x9gknd 1234 18 HR hr NN cord-010119-t1x9gknd 1234 19 5 5 CD cord-010119-t1x9gknd 1234 20 0.90 0.90 CD cord-010119-t1x9gknd 1234 21 ; ; : cord-010119-t1x9gknd 1234 22 95 95 CD cord-010119-t1x9gknd 1234 23 % % NN cord-010119-t1x9gknd 1234 24 CI ci NN cord-010119-t1x9gknd 1234 25 : : : cord-010119-t1x9gknd 1234 26 0.73 0.73 CD cord-010119-t1x9gknd 1234 27 , , , cord-010119-t1x9gknd 1234 28 1.10 1.10 CD cord-010119-t1x9gknd 1234 29 ; ; : cord-010119-t1x9gknd 1234 30 p p NN cord-010119-t1x9gknd 1234 31 5 5 CD cord-010119-t1x9gknd 1234 32 0.295 0.295 CD cord-010119-t1x9gknd 1234 33 ) ) -RRB- cord-010119-t1x9gknd 1234 34 . . . cord-010119-t1x9gknd 1235 1 In in IN cord-010119-t1x9gknd 1235 2 the the DT cord-010119-t1x9gknd 1235 3 sensitivity sensitivity NN cord-010119-t1x9gknd 1235 4 analyses analysis NNS cord-010119-t1x9gknd 1235 5 using use VBG cord-010119-t1x9gknd 1235 6 weekly weekly JJ cord-010119-t1x9gknd 1235 7 partitions partition NNS cord-010119-t1x9gknd 1235 8 , , , cord-010119-t1x9gknd 1235 9 exposure exposure NN cord-010119-t1x9gknd 1235 10 to to IN cord-010119-t1x9gknd 1235 11 RBCs rbc NNS cord-010119-t1x9gknd 1235 12 stored store VBN cord-010119-t1x9gknd 1235 13 for for IN cord-010119-t1x9gknd 1235 14 greater great JJR cord-010119-t1x9gknd 1235 15 than than IN cord-010119-t1x9gknd 1235 16 35 35 CD cord-010119-t1x9gknd 1235 17 days day NNS cord-010119-t1x9gknd 1235 18 compared compare VBN cord-010119-t1x9gknd 1235 19 to to IN cord-010119-t1x9gknd 1235 20 exclusive exclusive JJ cord-010119-t1x9gknd 1235 21 exposure exposure NN cord-010119-t1x9gknd 1235 22 to to IN cord-010119-t1x9gknd 1235 23 RBCs rbc NNS cord-010119-t1x9gknd 1235 24 stored store VBD cord-010119-t1x9gknd 1235 25 7 7 CD cord-010119-t1x9gknd 1235 26 days day NNS cord-010119-t1x9gknd 1235 27 or or CC cord-010119-t1x9gknd 1235 28 less less JJR cord-010119-t1x9gknd 1235 29 was be VBD cord-010119-t1x9gknd 1235 30 not not RB cord-010119-t1x9gknd 1235 31 significant significant JJ cord-010119-t1x9gknd 1236 1 ( ( -LRB- cord-010119-t1x9gknd 1236 2 HR HR NNP cord-010119-t1x9gknd 1236 3 0.90 0.90 CD cord-010119-t1x9gknd 1236 4 ; ; : cord-010119-t1x9gknd 1236 5 95 95 CD cord-010119-t1x9gknd 1236 6 % % NN cord-010119-t1x9gknd 1236 7 CI CI NNP cord-010119-t1x9gknd 1236 8 0.72 0.72 CD cord-010119-t1x9gknd 1236 9 , , , cord-010119-t1x9gknd 1236 10 1.14 1.14 CD cord-010119-t1x9gknd 1236 11 ; ; : cord-010119-t1x9gknd 1236 12 p p NN cord-010119-t1x9gknd 1236 13 5 5 CD cord-010119-t1x9gknd 1236 14 0.381 0.381 CD cord-010119-t1x9gknd 1236 15 ) ) -RRB- cord-010119-t1x9gknd 1236 16 . . . cord-010119-t1x9gknd 1237 1 The the DT cord-010119-t1x9gknd 1237 2 confidence confidence NN cord-010119-t1x9gknd 1237 3 intervals interval NNS cord-010119-t1x9gknd 1237 4 around around IN cord-010119-t1x9gknd 1237 5 the the DT cord-010119-t1x9gknd 1237 6 hazard hazard NN cord-010119-t1x9gknd 1237 7 ratios ratio NNS cord-010119-t1x9gknd 1237 8 for for IN cord-010119-t1x9gknd 1237 9 the the DT cord-010119-t1x9gknd 1237 10 other other JJ cord-010119-t1x9gknd 1237 11 7-day 7-day JJ cord-010119-t1x9gknd 1237 12 intervals interval NNS cord-010119-t1x9gknd 1237 13 all all DT cord-010119-t1x9gknd 1237 14 include include VBP cord-010119-t1x9gknd 1237 15 1 1 CD cord-010119-t1x9gknd 1237 16 . . . cord-010119-t1x9gknd 1238 1 Similar similar JJ cord-010119-t1x9gknd 1238 2 findings finding NNS cord-010119-t1x9gknd 1238 3 were be VBD cord-010119-t1x9gknd 1238 4 obtained obtain VBN cord-010119-t1x9gknd 1238 5 with with IN cord-010119-t1x9gknd 1238 6 partitioning partition VBG cord-010119-t1x9gknd 1238 7 exposure exposure NN cord-010119-t1x9gknd 1238 8 data datum NNS cord-010119-t1x9gknd 1238 9 into into IN cord-010119-t1x9gknd 1238 10 3 3 CD cord-010119-t1x9gknd 1238 11 day day NN cord-010119-t1x9gknd 1238 12 intervals interval NNS cord-010119-t1x9gknd 1238 13 where where WRB cord-010119-t1x9gknd 1238 14 exposure exposure NN cord-010119-t1x9gknd 1238 15 to to IN cord-010119-t1x9gknd 1238 16 RBCs rbc NNS cord-010119-t1x9gknd 1238 17 stored store VBN cord-010119-t1x9gknd 1238 18 for for IN cord-010119-t1x9gknd 1238 19 40 40 CD cord-010119-t1x9gknd 1238 20 - - SYM cord-010119-t1x9gknd 1238 21 42 42 CD cord-010119-t1x9gknd 1238 22 days day NNS cord-010119-t1x9gknd 1238 23 was be VBD cord-010119-t1x9gknd 1238 24 not not RB cord-010119-t1x9gknd 1238 25 associated associate VBN cord-010119-t1x9gknd 1238 26 with with IN cord-010119-t1x9gknd 1238 27 increased increase VBN cord-010119-t1x9gknd 1238 28 risk risk NN cord-010119-t1x9gknd 1238 29 of of IN cord-010119-t1x9gknd 1238 30 death death NN cord-010119-t1x9gknd 1238 31 compared compare VBN cord-010119-t1x9gknd 1238 32 with with IN cord-010119-t1x9gknd 1238 33 exclusive exclusive JJ cord-010119-t1x9gknd 1238 34 exposure exposure NN cord-010119-t1x9gknd 1238 35 to to IN cord-010119-t1x9gknd 1238 36 RBCs rbc NNS cord-010119-t1x9gknd 1238 37 stored store VBN cord-010119-t1x9gknd 1238 38 for for IN cord-010119-t1x9gknd 1238 39 1 1 CD cord-010119-t1x9gknd 1238 40 - - SYM cord-010119-t1x9gknd 1238 41 3 3 CD cord-010119-t1x9gknd 1238 42 days day NNS cord-010119-t1x9gknd 1238 43 ( ( -LRB- cord-010119-t1x9gknd 1238 44 HR hr NN cord-010119-t1x9gknd 1238 45 0.82 0.82 CD cord-010119-t1x9gknd 1238 46 ; ; : cord-010119-t1x9gknd 1238 47 95 95 CD cord-010119-t1x9gknd 1238 48 % % NN cord-010119-t1x9gknd 1238 49 CI CI NNP cord-010119-t1x9gknd 1238 50 0.37 0.37 CD cord-010119-t1x9gknd 1238 51 , , , cord-010119-t1x9gknd 1238 52 1.83 1.83 CD cord-010119-t1x9gknd 1238 53 ; ; : cord-010119-t1x9gknd 1238 54 p p NN cord-010119-t1x9gknd 1238 55 5 5 CD cord-010119-t1x9gknd 1238 56 0.635 0.635 CD cord-010119-t1x9gknd 1238 57 ) ) -RRB- cord-010119-t1x9gknd 1238 58 . . . cord-010119-t1x9gknd 1239 1 The the DT cord-010119-t1x9gknd 1239 2 confidence confidence NN cord-010119-t1x9gknd 1239 3 intervals interval NNS cord-010119-t1x9gknd 1239 4 around around IN cord-010119-t1x9gknd 1239 5 the the DT cord-010119-t1x9gknd 1239 6 hazard hazard NN cord-010119-t1x9gknd 1239 7 ratios ratio NNS cord-010119-t1x9gknd 1239 8 for for IN cord-010119-t1x9gknd 1239 9 the the DT cord-010119-t1x9gknd 1239 10 other other JJ cord-010119-t1x9gknd 1239 11 3-day 3-day JJ cord-010119-t1x9gknd 1239 12 intervals interval NNS cord-010119-t1x9gknd 1239 13 all all DT cord-010119-t1x9gknd 1239 14 include include VBP cord-010119-t1x9gknd 1239 15 1 1 CD cord-010119-t1x9gknd 1239 16 . . . cord-010119-t1x9gknd 1240 1 Conclusion conclusion NN cord-010119-t1x9gknd 1240 2 : : : cord-010119-t1x9gknd 1240 3 Individuals individual NNS cord-010119-t1x9gknd 1240 4 exposed expose VBN cord-010119-t1x9gknd 1240 5 to to IN cord-010119-t1x9gknd 1240 6 RBCs rbc NNS cord-010119-t1x9gknd 1240 7 stored store VBN cord-010119-t1x9gknd 1240 8 for for IN cord-010119-t1x9gknd 1240 9 more more JJR cord-010119-t1x9gknd 1240 10 than than IN cord-010119-t1x9gknd 1240 11 35 35 CD cord-010119-t1x9gknd 1240 12 days day NNS cord-010119-t1x9gknd 1240 13 were be VBD cord-010119-t1x9gknd 1240 14 not not RB cord-010119-t1x9gknd 1240 15 at at IN cord-010119-t1x9gknd 1240 16 increased increase VBN cord-010119-t1x9gknd 1240 17 risk risk NN cord-010119-t1x9gknd 1240 18 of of IN cord-010119-t1x9gknd 1240 19 in in IN cord-010119-t1x9gknd 1240 20 - - HYPH cord-010119-t1x9gknd 1240 21 hospital hospital NN cord-010119-t1x9gknd 1240 22 death death NN cord-010119-t1x9gknd 1240 23 compared compare VBN cord-010119-t1x9gknd 1240 24 to to IN cord-010119-t1x9gknd 1240 25 individuals individual NNS cord-010119-t1x9gknd 1240 26 exposed expose VBN cord-010119-t1x9gknd 1240 27 exclusively exclusively RB cord-010119-t1x9gknd 1240 28 to to IN cord-010119-t1x9gknd 1240 29 RBCs rbc NNS cord-010119-t1x9gknd 1240 30 stored store VBN cord-010119-t1x9gknd 1240 31 for for IN cord-010119-t1x9gknd 1240 32 7 7 CD cord-010119-t1x9gknd 1240 33 days day NNS cord-010119-t1x9gknd 1240 34 or or CC cord-010119-t1x9gknd 1240 35 less less JJR cord-010119-t1x9gknd 1240 36 . . . cord-010119-t1x9gknd 1241 1 Transfusion transfusion NN cord-010119-t1x9gknd 1241 2 of of IN cord-010119-t1x9gknd 1241 3 Anaerobically Anaerobically NNP cord-010119-t1x9gknd 1241 4 Stored store VBD cord-010119-t1x9gknd 1241 5 Red Red NNP cord-010119-t1x9gknd 1241 6 Blood Blood NNP cord-010119-t1x9gknd 1241 7 Cells Cells NNPS cord-010119-t1x9gknd 1241 8 Improves improve VBZ cord-010119-t1x9gknd 1241 9 Recovery Recovery NNP cord-010119-t1x9gknd 1241 10 in in IN cord-010119-t1x9gknd 1241 11 Experimental experimental JJ cord-010119-t1x9gknd 1241 12 Rat Rat NNP cord-010119-t1x9gknd 1241 13 Hemorrhagic Hemorrhagic NNP cord-010119-t1x9gknd 1241 14 Shock Shock NNP cord-010119-t1x9gknd 1241 15 Model Model NNP cord-010119-t1x9gknd 1241 16 Alexander Alexander NNP cord-010119-t1x9gknd 1241 17 Williams Williams NNP cord-010119-t1x9gknd 1242 1 * * NFP cord-010119-t1x9gknd 1242 2 1 1 CD cord-010119-t1x9gknd 1242 3 , , , cord-010119-t1x9gknd 1242 4 Cynthia Cynthia NNP cord-010119-t1x9gknd 1242 5 Walser Walser NNP cord-010119-t1x9gknd 1242 6 1 1 CD cord-010119-t1x9gknd 1242 7 , , , cord-010119-t1x9gknd 1242 8 Tatsuro Tatsuro NNP cord-010119-t1x9gknd 1242 9 Yoshida Yoshida NNP cord-010119-t1x9gknd 1242 10 2 2 CD cord-010119-t1x9gknd 1242 11 , , , cord-010119-t1x9gknd 1242 12 Andrew Andrew NNP cord-010119-t1x9gknd 1242 13 Dunham Dunham NNP cord-010119-t1x9gknd 1242 14 2 2 CD cord-010119-t1x9gknd 1242 15 and and CC cord-010119-t1x9gknd 1242 16 Pedro Pedro NNP cord-010119-t1x9gknd 1242 17 Cabrales Cabrales NNP cord-010119-t1x9gknd 1242 18 1 1 CD cord-010119-t1x9gknd 1242 19 . . . cord-010119-t1x9gknd 1243 1 1 1 CD cord-010119-t1x9gknd 1243 2 University University NNP cord-010119-t1x9gknd 1243 3 of of IN cord-010119-t1x9gknd 1243 4 California California NNP cord-010119-t1x9gknd 1243 5 San San NNP cord-010119-t1x9gknd 1243 6 Diego Diego NNP cord-010119-t1x9gknd 1243 7 , , , cord-010119-t1x9gknd 1244 1 2 2 LS cord-010119-t1x9gknd 1244 2 New New NNP cord-010119-t1x9gknd 1244 3 Health Health NNP cord-010119-t1x9gknd 1244 4 Sciences Sciences NNPS cord-010119-t1x9gknd 1244 5 Inc. Inc. NNP cord-010119-t1x9gknd 1244 6 Background Background NNP cord-010119-t1x9gknd 1244 7 / / SYM cord-010119-t1x9gknd 1244 8 Case Case NNP cord-010119-t1x9gknd 1244 9 Studies Studies NNPS cord-010119-t1x9gknd 1244 10 : : : cord-010119-t1x9gknd 1244 11 Hemorrhagic hemorrhagic JJ cord-010119-t1x9gknd 1244 12 shock shock NN cord-010119-t1x9gknd 1244 13 ( ( -LRB- cord-010119-t1x9gknd 1244 14 HS HS NNP cord-010119-t1x9gknd 1244 15 ) ) -RRB- cord-010119-t1x9gknd 1245 1 severely severely RB cord-010119-t1x9gknd 1245 2 decreases decrease VBZ cord-010119-t1x9gknd 1245 3 oxygen oxygen NN cord-010119-t1x9gknd 1246 1 ( ( -LRB- cord-010119-t1x9gknd 1246 2 O o UH cord-010119-t1x9gknd 1246 3 2 2 CD cord-010119-t1x9gknd 1246 4 ) ) -RRB- cord-010119-t1x9gknd 1246 5 delivery delivery NN cord-010119-t1x9gknd 1246 6 and and CC cord-010119-t1x9gknd 1246 7 induces induce VBZ cord-010119-t1x9gknd 1246 8 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 1246 9 collapse collapse NN cord-010119-t1x9gknd 1246 10 . . . cord-010119-t1x9gknd 1247 1 In in IN cord-010119-t1x9gknd 1247 2 parallel parallel NN cord-010119-t1x9gknd 1247 3 to to IN cord-010119-t1x9gknd 1247 4 controlling control VBG cord-010119-t1x9gknd 1247 5 the the DT cord-010119-t1x9gknd 1247 6 hemorrhage hemorrhage NN cord-010119-t1x9gknd 1247 7 , , , cord-010119-t1x9gknd 1247 8 clinicians clinician NNS cord-010119-t1x9gknd 1247 9 respond respond VBP cord-010119-t1x9gknd 1247 10 by by IN cord-010119-t1x9gknd 1247 11 infusing infuse VBG cord-010119-t1x9gknd 1247 12 large large JJ cord-010119-t1x9gknd 1247 13 volumes volume NNS cord-010119-t1x9gknd 1247 14 of of IN cord-010119-t1x9gknd 1247 15 red red JJ cord-010119-t1x9gknd 1247 16 blood blood NN cord-010119-t1x9gknd 1247 17 cells cell NNS cord-010119-t1x9gknd 1247 18 ( ( -LRB- cord-010119-t1x9gknd 1247 19 RBCs rbc NNS cord-010119-t1x9gknd 1247 20 ) ) -RRB- cord-010119-t1x9gknd 1247 21 to to TO cord-010119-t1x9gknd 1247 22 restore restore VB cord-010119-t1x9gknd 1247 23 blood blood NN cord-010119-t1x9gknd 1247 24 volume volume NN cord-010119-t1x9gknd 1247 25 , , , cord-010119-t1x9gknd 1247 26 O o UH cord-010119-t1x9gknd 1247 27 2 2 CD cord-010119-t1x9gknd 1247 28 carrying carrying NN cord-010119-t1x9gknd 1247 29 capacity capacity NN cord-010119-t1x9gknd 1247 30 , , , cord-010119-t1x9gknd 1247 31 and and CC cord-010119-t1x9gknd 1247 32 hemodynamic hemodynamic JJ cord-010119-t1x9gknd 1247 33 stability stability NN cord-010119-t1x9gknd 1247 34 . . . cord-010119-t1x9gknd 1248 1 The the DT cord-010119-t1x9gknd 1248 2 quality quality NN cord-010119-t1x9gknd 1248 3 of of IN cord-010119-t1x9gknd 1248 4 the the DT cord-010119-t1x9gknd 1248 5 transfused transfuse VBN cord-010119-t1x9gknd 1248 6 RBCs rbc NNS cord-010119-t1x9gknd 1248 7 determines determine VBZ cord-010119-t1x9gknd 1248 8 the the DT cord-010119-t1x9gknd 1248 9 recovery recovery NN cord-010119-t1x9gknd 1248 10 from from IN cord-010119-t1x9gknd 1248 11 HS HS NNP cord-010119-t1x9gknd 1248 12 , , , cord-010119-t1x9gknd 1248 13 and and CC cord-010119-t1x9gknd 1248 14 extent extent NN cord-010119-t1x9gknd 1248 15 of of IN cord-010119-t1x9gknd 1248 16 clinical clinical JJ cord-010119-t1x9gknd 1248 17 sequelae sequela NNS cord-010119-t1x9gknd 1248 18 prompted prompt VBN cord-010119-t1x9gknd 1248 19 by by IN cord-010119-t1x9gknd 1248 20 the the DT cord-010119-t1x9gknd 1248 21 HS HS NNP cord-010119-t1x9gknd 1248 22 . . . cord-010119-t1x9gknd 1249 1 This this DT cord-010119-t1x9gknd 1249 2 study study NN cord-010119-t1x9gknd 1249 3 compares compare VBZ cord-010119-t1x9gknd 1249 4 the the DT cord-010119-t1x9gknd 1249 5 ability ability NN cord-010119-t1x9gknd 1249 6 to to TO cord-010119-t1x9gknd 1249 7 recover recover VB cord-010119-t1x9gknd 1249 8 from from IN cord-010119-t1x9gknd 1249 9 HS HS NNP cord-010119-t1x9gknd 1249 10 with with IN cord-010119-t1x9gknd 1249 11 conventionally conventionally RB cord-010119-t1x9gknd 1249 12 stored store VBN cord-010119-t1x9gknd 1249 13 RBCs rbc NNS cord-010119-t1x9gknd 1249 14 , , , cord-010119-t1x9gknd 1249 15 anaerobically anaerobically RB cord-010119-t1x9gknd 1249 16 ( ( -LRB- cord-010119-t1x9gknd 1249 17 O o UH cord-010119-t1x9gknd 1249 18 2 2 CD cord-010119-t1x9gknd 1249 19 saturation saturation NN cord-010119-t1x9gknd 1249 20 < < XX cord-010119-t1x9gknd 1249 21 10 10 CD cord-010119-t1x9gknd 1249 22 % % NN cord-010119-t1x9gknd 1249 23 ) ) -RRB- cord-010119-t1x9gknd 1249 24 stored store VBN cord-010119-t1x9gknd 1249 25 RBCs rbc NNS cord-010119-t1x9gknd 1249 26 , , , cord-010119-t1x9gknd 1249 27 or or CC cord-010119-t1x9gknd 1249 28 anaerobic anaerobic JJ cord-010119-t1x9gknd 1249 29 / / SYM cord-010119-t1x9gknd 1249 30 hypercapnic hypercapnic NNP cord-010119-t1x9gknd 1249 31 ( ( -LRB- cord-010119-t1x9gknd 1250 1 O o UH cord-010119-t1x9gknd 1250 2 2 2 CD cord-010119-t1x9gknd 1250 3 saturation saturation NN cord-010119-t1x9gknd 1250 4 < < XX cord-010119-t1x9gknd 1250 5 10 10 CD cord-010119-t1x9gknd 1250 6 % % NN cord-010119-t1x9gknd 1250 7 and and CC cord-010119-t1x9gknd 1250 8 pCO pco CD cord-010119-t1x9gknd 1250 9 2 2 CD cord-010119-t1x9gknd 1250 10 ( ( -LRB- cord-010119-t1x9gknd 1250 11 @378C @378c NN cord-010119-t1x9gknd 1250 12 ) ) -RRB- cord-010119-t1x9gknd 1251 1 $ $ $ cord-010119-t1x9gknd 1251 2 70mmHg 70mmhg CD cord-010119-t1x9gknd 1251 3 ) ) -RRB- cord-010119-t1x9gknd 1251 4 stored store VBN cord-010119-t1x9gknd 1251 5 RBCs rbc NNS cord-010119-t1x9gknd 1251 6 . . . cord-010119-t1x9gknd 1252 1 Study Study NNP cord-010119-t1x9gknd 1252 2 Design Design NNP cord-010119-t1x9gknd 1252 3 / / SYM cord-010119-t1x9gknd 1252 4 Method method NN cord-010119-t1x9gknd 1252 5 : : : cord-010119-t1x9gknd 1252 6 Packed packed JJ cord-010119-t1x9gknd 1252 7 red red JJ cord-010119-t1x9gknd 1252 8 blood blood NN cord-010119-t1x9gknd 1252 9 cells cell NNS cord-010119-t1x9gknd 1252 10 ( ( -LRB- cord-010119-t1x9gknd 1252 11 pRBCs prbcs RB cord-010119-t1x9gknd 1252 12 ) ) -RRB- cord-010119-t1x9gknd 1252 13 stored store VBN cord-010119-t1x9gknd 1252 14 in in IN cord-010119-t1x9gknd 1252 15 AS-3 AS-3 NNP cord-010119-t1x9gknd 1252 16 after after IN cord-010119-t1x9gknd 1252 17 leukorfiltration leukorfiltration NN cord-010119-t1x9gknd 1252 18 were be VBD cord-010119-t1x9gknd 1252 19 created create VBN cord-010119-t1x9gknd 1252 20 from from IN cord-010119-t1x9gknd 1252 21 donor donor NN cord-010119-t1x9gknd 1252 22 Sprague Sprague NNP cord-010119-t1x9gknd 1252 23 - - HYPH cord-010119-t1x9gknd 1252 24 Dawley Dawley NNP cord-010119-t1x9gknd 1252 25 rats rat NNS cord-010119-t1x9gknd 1252 26 . . . cord-010119-t1x9gknd 1253 1 pRBC pRBC NNP cord-010119-t1x9gknd 1253 2 units unit NNS cord-010119-t1x9gknd 1253 3 were be VBD cord-010119-t1x9gknd 1253 4 randomly randomly RB cord-010119-t1x9gknd 1253 5 stored store VBN cord-010119-t1x9gknd 1253 6 under under IN cord-010119-t1x9gknd 1253 7 either either DT cord-010119-t1x9gknd 1253 8 1 1 CD cord-010119-t1x9gknd 1253 9 ) ) -RRB- cord-010119-t1x9gknd 1254 1 conventional conventional JJ cord-010119-t1x9gknd 1254 2 ; ; : cord-010119-t1x9gknd 1254 3 2 2 LS cord-010119-t1x9gknd 1254 4 ) ) -RRB- cord-010119-t1x9gknd 1254 5 anaerobic anaerobic JJ cord-010119-t1x9gknd 1254 6 ; ; : cord-010119-t1x9gknd 1254 7 or or CC cord-010119-t1x9gknd 1254 8 3 3 LS cord-010119-t1x9gknd 1254 9 ) ) -RRB- cord-010119-t1x9gknd 1254 10 anaerobic anaerobic JJ cord-010119-t1x9gknd 1254 11 / / SYM cord-010119-t1x9gknd 1254 12 hypercapnic hypercapnic NN cord-010119-t1x9gknd 1254 13 conditions condition NNS cord-010119-t1x9gknd 1254 14 . . . cord-010119-t1x9gknd 1255 1 Rats rat NNS cord-010119-t1x9gknd 1255 2 ( ( -LRB- cord-010119-t1x9gknd 1255 3 150 150 CD cord-010119-t1x9gknd 1255 4 - - SYM cord-010119-t1x9gknd 1255 5 200 200 CD cord-010119-t1x9gknd 1255 6 g g NN cord-010119-t1x9gknd 1255 7 ) ) -RRB- cord-010119-t1x9gknd 1255 8 were be VBD cord-010119-t1x9gknd 1255 9 hemorrhaged hemorrhage VBN cord-010119-t1x9gknd 1255 10 to to IN cord-010119-t1x9gknd 1255 11 50 50 CD cord-010119-t1x9gknd 1255 12 % % NN cord-010119-t1x9gknd 1255 13 of of IN cord-010119-t1x9gknd 1255 14 blood blood NN cord-010119-t1x9gknd 1255 15 volume volume NN cord-010119-t1x9gknd 1255 16 , , , cord-010119-t1x9gknd 1255 17 held hold VBN cord-010119-t1x9gknd 1255 18 in in IN cord-010119-t1x9gknd 1255 19 hypovolemia hypovolemia NN cord-010119-t1x9gknd 1255 20 for for IN cord-010119-t1x9gknd 1255 21 30 30 CD cord-010119-t1x9gknd 1255 22 minutes minute NNS cord-010119-t1x9gknd 1255 23 , , , cord-010119-t1x9gknd 1255 24 and and CC cord-010119-t1x9gknd 1255 25 resuscitated resuscitate VBD cord-010119-t1x9gknd 1255 26 to to TO cord-010119-t1x9gknd 1255 27 recover recover VB cord-010119-t1x9gknd 1255 28 blood blood NN cord-010119-t1x9gknd 1255 29 pressure pressure NN cord-010119-t1x9gknd 1255 30 to to IN cord-010119-t1x9gknd 1255 31 90 90 CD cord-010119-t1x9gknd 1255 32 % % NN cord-010119-t1x9gknd 1255 33 pre pre JJ cord-010119-t1x9gknd 1255 34 - - NN cord-010119-t1x9gknd 1255 35 hemorrhage hemorrhage NN cord-010119-t1x9gknd 1255 36 with with IN cord-010119-t1x9gknd 1255 37 pRBC prbc JJ cord-010119-t1x9gknd 1255 38 stored store VBN cord-010119-t1x9gknd 1255 39 for for IN cord-010119-t1x9gknd 1255 40 either either DT cord-010119-t1x9gknd 1255 41 1 1 CD cord-010119-t1x9gknd 1255 42 or or CC cord-010119-t1x9gknd 1255 43 3 3 CD cord-010119-t1x9gknd 1255 44 weeks week NNS cord-010119-t1x9gknd 1255 45 . . . cord-010119-t1x9gknd 1256 1 Systemic systemic JJ cord-010119-t1x9gknd 1256 2 hemodynamics hemodynamic NNS cord-010119-t1x9gknd 1256 3 , , , cord-010119-t1x9gknd 1256 4 cardiac cardiac JJ cord-010119-t1x9gknd 1256 5 function function NN cord-010119-t1x9gknd 1256 6 , , , cord-010119-t1x9gknd 1256 7 and and CC cord-010119-t1x9gknd 1256 8 blood blood NN cord-010119-t1x9gknd 1256 9 gas gas NN cord-010119-t1x9gknd 1256 10 parameters parameter NNS cord-010119-t1x9gknd 1256 11 were be VBD cord-010119-t1x9gknd 1256 12 monitored monitor VBN cord-010119-t1x9gknd 1256 13 during during IN cord-010119-t1x9gknd 1256 14 shock shock NN cord-010119-t1x9gknd 1256 15 and and CC cord-010119-t1x9gknd 1256 16 resuscitation resuscitation NN cord-010119-t1x9gknd 1256 17 ; ; : cord-010119-t1x9gknd 1256 18 and and CC cord-010119-t1x9gknd 1256 19 vital vital JJ cord-010119-t1x9gknd 1256 20 organ organ NN cord-010119-t1x9gknd 1256 21 inflammation inflammation NN cord-010119-t1x9gknd 1256 22 , , , cord-010119-t1x9gknd 1256 23 oxygenation oxygenation NN cord-010119-t1x9gknd 1256 24 , , , cord-010119-t1x9gknd 1256 25 and and CC cord-010119-t1x9gknd 1256 26 function function NN cord-010119-t1x9gknd 1256 27 were be VBD cord-010119-t1x9gknd 1256 28 evaluated evaluate VBN cord-010119-t1x9gknd 1256 29 post post JJ cord-010119-t1x9gknd 1256 30 resuscitation resuscitation NN cord-010119-t1x9gknd 1256 31 . . . cord-010119-t1x9gknd 1257 1 Data datum NNS cord-010119-t1x9gknd 1257 2 were be VBD cord-010119-t1x9gknd 1257 3 analyzed analyze VBN cord-010119-t1x9gknd 1257 4 using use VBG cord-010119-t1x9gknd 1257 5 two two CD cord-010119-t1x9gknd 1257 6 - - HYPH cord-010119-t1x9gknd 1257 7 way way NN cord-010119-t1x9gknd 1257 8 ANOVA ANOVA NNP cord-010119-t1x9gknd 1257 9 , , , cord-010119-t1x9gknd 1257 10 followed follow VBN cord-010119-t1x9gknd 1257 11 by by IN cord-010119-t1x9gknd 1257 12 the the DT cord-010119-t1x9gknd 1257 13 appropriate appropriate JJ cord-010119-t1x9gknd 1257 14 post post FW cord-010119-t1x9gknd 1257 15 hoc hoc FW cord-010119-t1x9gknd 1257 16 analyses analysis NNS cord-010119-t1x9gknd 1257 17 . . . cord-010119-t1x9gknd 1258 1 1(11 1(11 CD cord-010119-t1x9gknd 1258 2 % % NN cord-010119-t1x9gknd 1258 3 ) ) -RRB- cord-010119-t1x9gknd 1259 1 NEG NEG NNP cord-010119-t1x9gknd 1259 2 patient patient NN cord-010119-t1x9gknd 1259 3 showed show VBD cord-010119-t1x9gknd 1259 4 short short JJ cord-010119-t1x9gknd 1259 5 term term NN cord-010119-t1x9gknd 1259 6 response response NN cord-010119-t1x9gknd 1259 7 and and CC cord-010119-t1x9gknd 1259 8 6(67 6(67 CD cord-010119-t1x9gknd 1259 9 % % NN cord-010119-t1x9gknd 1259 10 ) ) -RRB- cord-010119-t1x9gknd 1259 11 patients patient NNS cord-010119-t1x9gknd 1259 12 showed show VBD cord-010119-t1x9gknd 1259 13 progressive progressive JJ cord-010119-t1x9gknd 1259 14 disease disease NN cord-010119-t1x9gknd 1259 15 . . . cord-010119-t1x9gknd 1260 1 At at IN cord-010119-t1x9gknd 1260 2 the the DT cord-010119-t1x9gknd 1260 3 NEG NEG NNP cord-010119-t1x9gknd 1260 4 group group NN cord-010119-t1x9gknd 1260 5 standard standard NN cord-010119-t1x9gknd 1260 6 eval eval NN cord-010119-t1x9gknd 1260 7 1(11 1(11 CD cord-010119-t1x9gknd 1260 8 % % NN cord-010119-t1x9gknd 1260 9 ) ) -RRB- cord-010119-t1x9gknd 1260 10 patient patient NN cord-010119-t1x9gknd 1260 11 showed show VBD cord-010119-t1x9gknd 1260 12 response response NN cord-010119-t1x9gknd 1260 13 and and CC cord-010119-t1x9gknd 1260 14 3(33 3(33 CD cord-010119-t1x9gknd 1260 15 % % NN cord-010119-t1x9gknd 1260 16 ) ) -RRB- cord-010119-t1x9gknd 1260 17 had have VBD cord-010119-t1x9gknd 1260 18 progressive progressive JJ cord-010119-t1x9gknd 1260 19 disease disease NN cord-010119-t1x9gknd 1260 20 . . . cord-010119-t1x9gknd 1261 1 1(11 1(11 CD cord-010119-t1x9gknd 1261 2 % % NN cord-010119-t1x9gknd 1261 3 ) ) -RRB- cord-010119-t1x9gknd 1262 1 NEG NEG NNP cord-010119-t1x9gknd 1262 2 patient patient NN cord-010119-t1x9gknd 1262 3 had have VBD cord-010119-t1x9gknd 1262 4 long long JJ cord-010119-t1x9gknd 1262 5 term term NN cord-010119-t1x9gknd 1262 6 response response NN cord-010119-t1x9gknd 1262 7 compared compare VBN cord-010119-t1x9gknd 1262 8 to to IN cord-010119-t1x9gknd 1262 9 11(21 11(21 CD cord-010119-t1x9gknd 1262 10 % % NN cord-010119-t1x9gknd 1262 11 ) ) -RRB- cord-010119-t1x9gknd 1262 12 POS POS NNP cord-010119-t1x9gknd 1262 13 patients patient NNS cord-010119-t1x9gknd 1262 14 . . . cord-010119-t1x9gknd 1263 1 At at IN cord-010119-t1x9gknd 1263 2 the the DT cord-010119-t1x9gknd 1263 3 POS POS NNP cord-010119-t1x9gknd 1263 4 short short JJ cord-010119-t1x9gknd 1263 5 term term NN cord-010119-t1x9gknd 1263 6 eval eval NN cord-010119-t1x9gknd 1263 7 22(42 22(42 CD cord-010119-t1x9gknd 1263 8 % % NN cord-010119-t1x9gknd 1263 9 ) ) -RRB- cord-010119-t1x9gknd 1263 10 patients patient NNS cord-010119-t1x9gknd 1263 11 showed show VBD cord-010119-t1x9gknd 1263 12 response response NN cord-010119-t1x9gknd 1263 13 and and CC cord-010119-t1x9gknd 1263 14 20(38 20(38 CD cord-010119-t1x9gknd 1263 15 % % NN cord-010119-t1x9gknd 1263 16 ) ) -RRB- cord-010119-t1x9gknd 1263 17 patients patient NNS cord-010119-t1x9gknd 1263 18 had have VBD cord-010119-t1x9gknd 1263 19 progressive progressive JJ cord-010119-t1x9gknd 1263 20 disease disease NN cord-010119-t1x9gknd 1263 21 . . . cord-010119-t1x9gknd 1264 1 At at IN cord-010119-t1x9gknd 1264 2 the the DT cord-010119-t1x9gknd 1264 3 POS POS NNP cord-010119-t1x9gknd 1264 4 group group NN cord-010119-t1x9gknd 1264 5 standard standard NN cord-010119-t1x9gknd 1264 6 eval eval NN cord-010119-t1x9gknd 1264 7 , , , cord-010119-t1x9gknd 1264 8 20(38 20(38 CD cord-010119-t1x9gknd 1264 9 % % NN cord-010119-t1x9gknd 1264 10 ) ) -RRB- cord-010119-t1x9gknd 1264 11 patients patient NNS cord-010119-t1x9gknd 1264 12 showed show VBD cord-010119-t1x9gknd 1264 13 response response NN cord-010119-t1x9gknd 1264 14 and and CC cord-010119-t1x9gknd 1264 15 6(11 6(11 CD cord-010119-t1x9gknd 1264 16 % % NN cord-010119-t1x9gknd 1264 17 ) ) -RRB- cord-010119-t1x9gknd 1264 18 patients patient NNS cord-010119-t1x9gknd 1264 19 had have VBD cord-010119-t1x9gknd 1264 20 progressive progressive JJ cord-010119-t1x9gknd 1264 21 disease disease NN cord-010119-t1x9gknd 1264 22 . . . cord-010119-t1x9gknd 1265 1 Overall overall RB cord-010119-t1x9gknd 1265 2 , , , cord-010119-t1x9gknd 1265 3 28(53 28(53 CD cord-010119-t1x9gknd 1265 4 % % NN cord-010119-t1x9gknd 1265 5 ) ) -RRB- cord-010119-t1x9gknd 1265 6 POS POS NNP cord-010119-t1x9gknd 1265 7 patients patient NNS cord-010119-t1x9gknd 1265 8 responded respond VBD cord-010119-t1x9gknd 1265 9 compared compare VBN cord-010119-t1x9gknd 1265 10 to to IN cord-010119-t1x9gknd 1265 11 2(22 2(22 CD cord-010119-t1x9gknd 1265 12 % % NN cord-010119-t1x9gknd 1265 13 ) ) -RRB- cord-010119-t1x9gknd 1265 14 NEG NEG NNP cord-010119-t1x9gknd 1265 15 . . . cord-010119-t1x9gknd 1266 1 Conclusion conclusion NN cord-010119-t1x9gknd 1266 2 : : : cord-010119-t1x9gknd 1267 1 There there EX cord-010119-t1x9gknd 1267 2 is be VBZ cord-010119-t1x9gknd 1267 3 a a DT cord-010119-t1x9gknd 1267 4 trend trend NN cord-010119-t1x9gknd 1267 5 in in IN cord-010119-t1x9gknd 1267 6 lower low JJR cord-010119-t1x9gknd 1267 7 response response NN cord-010119-t1x9gknd 1267 8 rate rate NN cord-010119-t1x9gknd 1267 9 in in IN cord-010119-t1x9gknd 1267 10 patients patient NNS cord-010119-t1x9gknd 1267 11 with with IN cord-010119-t1x9gknd 1267 12 negative negative JJ cord-010119-t1x9gknd 1267 13 antibody antibody NN cord-010119-t1x9gknd 1267 14 screens screen NNS cord-010119-t1x9gknd 1267 15 compared compare VBN cord-010119-t1x9gknd 1267 16 to to IN cord-010119-t1x9gknd 1267 17 positive positive JJ cord-010119-t1x9gknd 1267 18 controls control NNS cord-010119-t1x9gknd 1267 19 . . . cord-010119-t1x9gknd 1268 1 These these DT cord-010119-t1x9gknd 1268 2 findings finding NNS cord-010119-t1x9gknd 1268 3 suggest suggest VBP cord-010119-t1x9gknd 1268 4 that that IN cord-010119-t1x9gknd 1268 5 an an DT cord-010119-t1x9gknd 1268 6 anti anti JJ cord-010119-t1x9gknd 1268 7 - - JJ cord-010119-t1x9gknd 1268 8 CD38 cd38 JJ cord-010119-t1x9gknd 1268 9 neutralizing neutralize VBG cord-010119-t1x9gknd 1268 10 substance substance NN cord-010119-t1x9gknd 1268 11 could could MD cord-010119-t1x9gknd 1268 12 play play VB cord-010119-t1x9gknd 1268 13 a a DT cord-010119-t1x9gknd 1268 14 role role NN cord-010119-t1x9gknd 1268 15 in in IN cord-010119-t1x9gknd 1268 16 treatment treatment NN cord-010119-t1x9gknd 1268 17 response response NN cord-010119-t1x9gknd 1268 18 . . . cord-010119-t1x9gknd 1269 1 Alternatively alternatively RB cord-010119-t1x9gknd 1269 2 , , , cord-010119-t1x9gknd 1269 3 reduced reduce VBN cord-010119-t1x9gknd 1269 4 CD38 CD38 NNP cord-010119-t1x9gknd 1269 5 expression expression NN cord-010119-t1x9gknd 1269 6 may may MD cord-010119-t1x9gknd 1269 7 also also RB cord-010119-t1x9gknd 1269 8 contribute contribute VB cord-010119-t1x9gknd 1269 9 . . . cord-010119-t1x9gknd 1270 1 The the DT cord-010119-t1x9gknd 1270 2 low low JJ cord-010119-t1x9gknd 1270 3 response response NN cord-010119-t1x9gknd 1270 4 rates rate NNS cord-010119-t1x9gknd 1270 5 seen see VBN cord-010119-t1x9gknd 1270 6 in in IN cord-010119-t1x9gknd 1270 7 both both DT cord-010119-t1x9gknd 1270 8 groups group NNS cord-010119-t1x9gknd 1270 9 may may MD cord-010119-t1x9gknd 1270 10 result result VB cord-010119-t1x9gknd 1270 11 from from IN cord-010119-t1x9gknd 1270 12 biased biased JJ cord-010119-t1x9gknd 1270 13 selection selection NN cord-010119-t1x9gknd 1270 14 . . . cord-010119-t1x9gknd 1271 1 The the DT cord-010119-t1x9gknd 1271 2 need need NN cord-010119-t1x9gknd 1271 3 for for IN cord-010119-t1x9gknd 1271 4 repeat repeat NN cord-010119-t1x9gknd 1271 5 T&S t&s NN cord-010119-t1x9gknd 1271 6 and and CC cord-010119-t1x9gknd 1271 7 presumed presume VBN cord-010119-t1x9gknd 1271 8 repeat repeat NN cord-010119-t1x9gknd 1271 9 transfusions transfusion NNS cord-010119-t1x9gknd 1271 10 may may MD cord-010119-t1x9gknd 1271 11 be be VB cord-010119-t1x9gknd 1271 12 preselecting preselecte VBG cord-010119-t1x9gknd 1271 13 patients patient NNS cord-010119-t1x9gknd 1271 14 with with IN cord-010119-t1x9gknd 1271 15 more more RBR cord-010119-t1x9gknd 1271 16 aggressive aggressive JJ cord-010119-t1x9gknd 1271 17 disease disease NN cord-010119-t1x9gknd 1271 18 . . . cord-010119-t1x9gknd 1272 1 Also also RB cord-010119-t1x9gknd 1272 2 , , , cord-010119-t1x9gknd 1272 3 only only RB cord-010119-t1x9gknd 1272 4 a a DT cord-010119-t1x9gknd 1272 5 small small JJ cord-010119-t1x9gknd 1272 6 number number NN cord-010119-t1x9gknd 1272 7 of of IN cord-010119-t1x9gknd 1272 8 patients patient NNS cord-010119-t1x9gknd 1272 9 were be VBD cord-010119-t1x9gknd 1272 10 suitable suitable JJ cord-010119-t1x9gknd 1272 11 for for IN cord-010119-t1x9gknd 1272 12 review review NN cord-010119-t1x9gknd 1272 13 . . . cord-010119-t1x9gknd 1273 1 A a DT cord-010119-t1x9gknd 1273 2 larger large JJR cord-010119-t1x9gknd 1273 3 prospective prospective JJ cord-010119-t1x9gknd 1273 4 study study NN cord-010119-t1x9gknd 1273 5 that that WDT cord-010119-t1x9gknd 1273 6 controls control VBZ cord-010119-t1x9gknd 1273 7 for for IN cord-010119-t1x9gknd 1273 8 such such JJ cord-010119-t1x9gknd 1273 9 variables variable NNS cord-010119-t1x9gknd 1273 10 is be VBZ cord-010119-t1x9gknd 1273 11 needed need VBN cord-010119-t1x9gknd 1273 12 . . . cord-010119-t1x9gknd 1274 1 A a DT cord-010119-t1x9gknd 1274 2 Review Review NNP cord-010119-t1x9gknd 1274 3 of of IN cord-010119-t1x9gknd 1274 4 Blood blood NN cord-010119-t1x9gknd 1274 5 Utilized utilize VBN cord-010119-t1x9gknd 1274 6 during during IN cord-010119-t1x9gknd 1274 7 Provider Provider NNP cord-010119-t1x9gknd 1274 8 - - HYPH cord-010119-t1x9gknd 1274 9 Activated Activated NNP cord-010119-t1x9gknd 1274 10 and and CC cord-010119-t1x9gknd 1274 11 Critical Critical NNP cord-010119-t1x9gknd 1274 12 Administration Administration NNP cord-010119-t1x9gknd 1275 1 Threshold threshold NN cord-010119-t1x9gknd 1275 2 - - HYPH cord-010119-t1x9gknd 1275 3 Triggered trigger VBN cord-010119-t1x9gknd 1275 4 Massive Massive NNP cord-010119-t1x9gknd 1275 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 1275 6 Events event NNS cord-010119-t1x9gknd 1275 7 Patrick Patrick NNP cord-010119-t1x9gknd 1275 8 Ramos Ramos NNP cord-010119-t1x9gknd 1275 9 * * NFP cord-010119-t1x9gknd 1275 10 and and CC cord-010119-t1x9gknd 1275 11 John John NNP cord-010119-t1x9gknd 1275 12 Hess Hess NNP cord-010119-t1x9gknd 1275 13 . . . cord-010119-t1x9gknd 1276 1 Division Division NNP cord-010119-t1x9gknd 1276 2 of of IN cord-010119-t1x9gknd 1276 3 Transfusion Transfusion NNP cord-010119-t1x9gknd 1276 4 Medicine Medicine NNP cord-010119-t1x9gknd 1276 5 , , , cord-010119-t1x9gknd 1276 6 Harborview Harborview NNP cord-010119-t1x9gknd 1276 7 Medical Medical NNP cord-010119-t1x9gknd 1276 8 Center Center NNP cord-010119-t1x9gknd 1276 9 Background Background NNP cord-010119-t1x9gknd 1276 10 / / SYM cord-010119-t1x9gknd 1276 11 Case Case NNP cord-010119-t1x9gknd 1276 12 Studies Studies NNPS cord-010119-t1x9gknd 1276 13 : : : cord-010119-t1x9gknd 1276 14 Traditional traditional JJ cord-010119-t1x9gknd 1276 15 definitions definition NNS cord-010119-t1x9gknd 1276 16 of of IN cord-010119-t1x9gknd 1276 17 massive massive JJ cord-010119-t1x9gknd 1276 18 transfusions transfusion NNS cord-010119-t1x9gknd 1276 19 -e.g -e.g ADD cord-010119-t1x9gknd 1276 20 . . . cord-010119-t1x9gknd 1277 1 , , , cord-010119-t1x9gknd 1277 2 the the DT cord-010119-t1x9gknd 1277 3 transfusion transfusion NN cord-010119-t1x9gknd 1277 4 of of IN cord-010119-t1x9gknd 1277 5 ten ten CD cord-010119-t1x9gknd 1277 6 or or CC cord-010119-t1x9gknd 1277 7 more more JJR cord-010119-t1x9gknd 1277 8 units unit NNS cord-010119-t1x9gknd 1277 9 of of IN cord-010119-t1x9gknd 1277 10 red red JJ cord-010119-t1x9gknd 1277 11 blood blood NN cord-010119-t1x9gknd 1277 12 cells cell NNS cord-010119-t1x9gknd 1277 13 ( ( -LRB- cord-010119-t1x9gknd 1277 14 RBCs rbc NNS cord-010119-t1x9gknd 1277 15 ) ) -RRB- cord-010119-t1x9gknd 1277 16 in in IN cord-010119-t1x9gknd 1277 17 a a DT cord-010119-t1x9gknd 1277 18 24-hour 24-hour JJ cord-010119-t1x9gknd 1277 19 period period NN cord-010119-t1x9gknd 1277 20 -are -are HYPH cord-010119-t1x9gknd 1277 21 limited limit VBN cord-010119-t1x9gknd 1277 22 in in IN cord-010119-t1x9gknd 1277 23 prospectively prospectively RB cord-010119-t1x9gknd 1277 24 identifying identify VBG cord-010119-t1x9gknd 1277 25 patients patient NNS cord-010119-t1x9gknd 1277 26 requiring require VBG cord-010119-t1x9gknd 1277 27 massive massive JJ cord-010119-t1x9gknd 1277 28 transfusions transfusion NNS cord-010119-t1x9gknd 1277 29 , , , cord-010119-t1x9gknd 1277 30 excluded exclude VBN cord-010119-t1x9gknd 1277 31 patients patient NNS cord-010119-t1x9gknd 1277 32 who who WP cord-010119-t1x9gknd 1277 33 may may MD cord-010119-t1x9gknd 1277 34 not not RB cord-010119-t1x9gknd 1277 35 survive survive VB cord-010119-t1x9gknd 1277 36 long long RB cord-010119-t1x9gknd 1277 37 enough enough RB cord-010119-t1x9gknd 1277 38 to to TO cord-010119-t1x9gknd 1277 39 meet meet VB cord-010119-t1x9gknd 1277 40 criteria criterion NNS cord-010119-t1x9gknd 1277 41 , , , cord-010119-t1x9gknd 1277 42 or or CC cord-010119-t1x9gknd 1277 43 ignored ignore VBD cord-010119-t1x9gknd 1277 44 the the DT cord-010119-t1x9gknd 1277 45 acuity acuity NN cord-010119-t1x9gknd 1277 46 of of IN cord-010119-t1x9gknd 1277 47 the the DT cord-010119-t1x9gknd 1277 48 event event NN cord-010119-t1x9gknd 1277 49 . . . cord-010119-t1x9gknd 1278 1 To to TO cord-010119-t1x9gknd 1278 2 address address VB cord-010119-t1x9gknd 1278 3 these these DT cord-010119-t1x9gknd 1278 4 issues issue NNS cord-010119-t1x9gknd 1278 5 , , , cord-010119-t1x9gknd 1278 6 a a DT cord-010119-t1x9gknd 1278 7 level level NN cord-010119-t1x9gknd 1278 8 I -PRON- PRP cord-010119-t1x9gknd 1278 9 trauma trauma NN cord-010119-t1x9gknd 1278 10 center center NN cord-010119-t1x9gknd 1278 11 adopted adopt VBD cord-010119-t1x9gknd 1278 12 the the DT cord-010119-t1x9gknd 1278 13 critical critical JJ cord-010119-t1x9gknd 1278 14 administration administration NN cord-010119-t1x9gknd 1278 15 threshold threshold NN cord-010119-t1x9gknd 1278 16 ( ( -LRB- cord-010119-t1x9gknd 1278 17 CAT cat NN cord-010119-t1x9gknd 1278 18 ) ) -RRB- cord-010119-t1x9gknd 1278 19 as as IN cord-010119-t1x9gknd 1278 20 an an DT cord-010119-t1x9gknd 1278 21 additional additional JJ cord-010119-t1x9gknd 1278 22 indication indication NN cord-010119-t1x9gknd 1278 23 for for IN cord-010119-t1x9gknd 1278 24 activating activate VBG cord-010119-t1x9gknd 1278 25 its -PRON- PRP$ cord-010119-t1x9gknd 1278 26 massive massive JJ cord-010119-t1x9gknd 1278 27 transfusion transfusion NN cord-010119-t1x9gknd 1278 28 protocol protocol NN cord-010119-t1x9gknd 1278 29 ( ( -LRB- cord-010119-t1x9gknd 1278 30 MTP MTP NNP cord-010119-t1x9gknd 1278 31 ) ) -RRB- cord-010119-t1x9gknd 1278 32 . . . cord-010119-t1x9gknd 1279 1 This this DT cord-010119-t1x9gknd 1279 2 study study NN cord-010119-t1x9gknd 1279 3 reviewed review VBD cord-010119-t1x9gknd 1279 4 blood blood NN cord-010119-t1x9gknd 1279 5 utilized utilize VBN cord-010119-t1x9gknd 1279 6 during during IN cord-010119-t1x9gknd 1279 7 massive massive JJ cord-010119-t1x9gknd 1279 8 transfusion transfusion NN cord-010119-t1x9gknd 1279 9 events event NNS cord-010119-t1x9gknd 1279 10 based base VBN cord-010119-t1x9gknd 1279 11 upon upon IN cord-010119-t1x9gknd 1279 12 whether whether IN cord-010119-t1x9gknd 1279 13 the the DT cord-010119-t1x9gknd 1279 14 MTP MTP NNP cord-010119-t1x9gknd 1279 15 was be VBD cord-010119-t1x9gknd 1279 16 provider provider NN cord-010119-t1x9gknd 1279 17 - - HYPH cord-010119-t1x9gknd 1279 18 activated activate VBN cord-010119-t1x9gknd 1279 19 versus versus IN cord-010119-t1x9gknd 1279 20 CAT cat NN cord-010119-t1x9gknd 1279 21 - - HYPH cord-010119-t1x9gknd 1279 22 triggered trigger VBN cord-010119-t1x9gknd 1279 23 . . . cord-010119-t1x9gknd 1280 1 Study Study NNP cord-010119-t1x9gknd 1280 2 Design Design NNP cord-010119-t1x9gknd 1280 3 / / SYM cord-010119-t1x9gknd 1280 4 Method method NN cord-010119-t1x9gknd 1280 5 : : : cord-010119-t1x9gknd 1281 1 All all DT cord-010119-t1x9gknd 1281 2 massive massive JJ cord-010119-t1x9gknd 1281 3 transfusion transfusion NN cord-010119-t1x9gknd 1281 4 events event NNS cord-010119-t1x9gknd 1281 5 between between IN cord-010119-t1x9gknd 1281 6 January January NNP cord-010119-t1x9gknd 1281 7 and and CC cord-010119-t1x9gknd 1281 8 April April NNP cord-010119-t1x9gknd 1281 9 2017 2017 CD cord-010119-t1x9gknd 1281 10 were be VBD cord-010119-t1x9gknd 1281 11 reviewed review VBN cord-010119-t1x9gknd 1281 12 to to TO cord-010119-t1x9gknd 1281 13 identify identify VB cord-010119-t1x9gknd 1281 14 the the DT cord-010119-t1x9gknd 1281 15 start start NN cord-010119-t1x9gknd 1281 16 time time NN cord-010119-t1x9gknd 1281 17 , , , cord-010119-t1x9gknd 1281 18 termination termination NN cord-010119-t1x9gknd 1281 19 time time NN cord-010119-t1x9gknd 1281 20 , , , cord-010119-t1x9gknd 1281 21 number number NN cord-010119-t1x9gknd 1281 22 of of IN cord-010119-t1x9gknd 1281 23 components component NNS cord-010119-t1x9gknd 1281 24 transfused transfuse VBN cord-010119-t1x9gknd 1281 25 , , , cord-010119-t1x9gknd 1281 26 and and CC cord-010119-t1x9gknd 1281 27 the the DT cord-010119-t1x9gknd 1281 28 start start NN cord-010119-t1x9gknd 1281 29 time time NN cord-010119-t1x9gknd 1281 30 of of IN cord-010119-t1x9gknd 1281 31 each each DT cord-010119-t1x9gknd 1281 32 component component NN cord-010119-t1x9gknd 1281 33 transfused transfuse VBN cord-010119-t1x9gknd 1281 34 . . . cord-010119-t1x9gknd 1282 1 The the DT cord-010119-t1x9gknd 1282 2 transfusion transfusion NN cord-010119-t1x9gknd 1282 3 of of IN cord-010119-t1x9gknd 1282 4 three three CD cord-010119-t1x9gknd 1282 5 or or CC cord-010119-t1x9gknd 1282 6 more more JJR cord-010119-t1x9gknd 1282 7 blood blood NN cord-010119-t1x9gknd 1282 8 components component NNS cord-010119-t1x9gknd 1282 9 in in IN cord-010119-t1x9gknd 1282 10 an an DT cord-010119-t1x9gknd 1282 11 hour hour NN cord-010119-t1x9gknd 1282 12 defined define VBN cord-010119-t1x9gknd 1282 13 CAT cat NN cord-010119-t1x9gknd 1282 14 . . . cord-010119-t1x9gknd 1283 1 A a DT cord-010119-t1x9gknd 1283 2 massive massive JJ cord-010119-t1x9gknd 1283 3 transfusion transfusion NN cord-010119-t1x9gknd 1283 4 was be VBD cord-010119-t1x9gknd 1283 5 any any DT cord-010119-t1x9gknd 1283 6 event event NN cord-010119-t1x9gknd 1283 7 in in IN cord-010119-t1x9gknd 1283 8 which which WDT cord-010119-t1x9gknd 1283 9 the the DT cord-010119-t1x9gknd 1283 10 concern concern NN cord-010119-t1x9gknd 1283 11 for for IN cord-010119-t1x9gknd 1283 12 hemorrhagic hemorrhagic JJ cord-010119-t1x9gknd 1283 13 shock shock NN cord-010119-t1x9gknd 1283 14 either either CC cord-010119-t1x9gknd 1283 15 necessitated necessitate VBD cord-010119-t1x9gknd 1283 16 a a DT cord-010119-t1x9gknd 1283 17 provider provider NN cord-010119-t1x9gknd 1283 18 to to TO cord-010119-t1x9gknd 1283 19 activate activate VB cord-010119-t1x9gknd 1283 20 the the DT cord-010119-t1x9gknd 1283 21 MTP MTP NNP cord-010119-t1x9gknd 1283 22 or or CC cord-010119-t1x9gknd 1283 23 blood blood NN cord-010119-t1x9gknd 1283 24 components component NNS cord-010119-t1x9gknd 1283 25 were be VBD cord-010119-t1x9gknd 1283 26 transfused transfuse VBN cord-010119-t1x9gknd 1283 27 at at IN cord-010119-t1x9gknd 1283 28 a a DT cord-010119-t1x9gknd 1283 29 rate rate NN cord-010119-t1x9gknd 1283 30 that that WDT cord-010119-t1x9gknd 1283 31 met meet VBD cord-010119-t1x9gknd 1283 32 CAT cat NN cord-010119-t1x9gknd 1283 33 criteria criterion NNS cord-010119-t1x9gknd 1283 34 . . . cord-010119-t1x9gknd 1284 1 The the DT cord-010119-t1x9gknd 1284 2 massive massive JJ cord-010119-t1x9gknd 1284 3 transfusion transfusion NN cord-010119-t1x9gknd 1284 4 start start NN cord-010119-t1x9gknd 1284 5 time time NN cord-010119-t1x9gknd 1284 6 is be VBZ cord-010119-t1x9gknd 1284 7 based base VBN cord-010119-t1x9gknd 1284 8 on on IN cord-010119-t1x9gknd 1284 9 either either CC cord-010119-t1x9gknd 1284 10 the the DT cord-010119-t1x9gknd 1284 11 time time NN cord-010119-t1x9gknd 1284 12 the the DT cord-010119-t1x9gknd 1284 13 provider provider NN cord-010119-t1x9gknd 1284 14 activated activate VBD cord-010119-t1x9gknd 1284 15 the the DT cord-010119-t1x9gknd 1284 16 MTP MTP NNP cord-010119-t1x9gknd 1284 17 or or CC cord-010119-t1x9gknd 1284 18 the the DT cord-010119-t1x9gknd 1284 19 time time NN cord-010119-t1x9gknd 1284 20 the the DT cord-010119-t1x9gknd 1284 21 first first JJ cord-010119-t1x9gknd 1284 22 blood blood NN cord-010119-t1x9gknd 1284 23 component component NN cord-010119-t1x9gknd 1284 24 was be VBD cord-010119-t1x9gknd 1284 25 transfused transfuse VBN cord-010119-t1x9gknd 1284 26 , , , cord-010119-t1x9gknd 1284 27 whichever whichever WDT cord-010119-t1x9gknd 1284 28 came come VBD cord-010119-t1x9gknd 1284 29 first first RB cord-010119-t1x9gknd 1284 30 . . . cord-010119-t1x9gknd 1285 1 Unless unless IN cord-010119-t1x9gknd 1285 2 the the DT cord-010119-t1x9gknd 1285 3 patient patient NN cord-010119-t1x9gknd 1285 4 expired expire VBD cord-010119-t1x9gknd 1285 5 first first RB cord-010119-t1x9gknd 1285 6 , , , cord-010119-t1x9gknd 1285 7 the the DT cord-010119-t1x9gknd 1285 8 termination termination NN cord-010119-t1x9gknd 1285 9 of of IN cord-010119-t1x9gknd 1285 10 the the DT cord-010119-t1x9gknd 1285 11 massive massive JJ cord-010119-t1x9gknd 1285 12 transfusion transfusion NN cord-010119-t1x9gknd 1285 13 event event NN cord-010119-t1x9gknd 1285 14 was be VBD cord-010119-t1x9gknd 1285 15 determined determine VBN cord-010119-t1x9gknd 1285 16 by by IN cord-010119-t1x9gknd 1285 17 identifying identify VBG cord-010119-t1x9gknd 1285 18 the the DT cord-010119-t1x9gknd 1285 19 point point NN cord-010119-t1x9gknd 1285 20 in in IN cord-010119-t1x9gknd 1285 21 time time NN cord-010119-t1x9gknd 1285 22 in in IN cord-010119-t1x9gknd 1285 23 which which WDT cord-010119-t1x9gknd 1285 24 the the DT cord-010119-t1x9gknd 1285 25 patient patient NN cord-010119-t1x9gknd 1285 26 went go VBD cord-010119-t1x9gknd 1285 27 three three CD cord-010119-t1x9gknd 1285 28 or or CC cord-010119-t1x9gknd 1285 29 more more JJR cord-010119-t1x9gknd 1285 30 hours hour NNS cord-010119-t1x9gknd 1285 31 without without IN cord-010119-t1x9gknd 1285 32 the the DT cord-010119-t1x9gknd 1285 33 transfusion transfusion NN cord-010119-t1x9gknd 1285 34 of of IN cord-010119-t1x9gknd 1285 35 any any DT cord-010119-t1x9gknd 1285 36 additional additional JJ cord-010119-t1x9gknd 1285 37 blood blood NN cord-010119-t1x9gknd 1285 38 components component NNS cord-010119-t1x9gknd 1285 39 . . . cord-010119-t1x9gknd 1286 1 This this DT cord-010119-t1x9gknd 1286 2 information information NN cord-010119-t1x9gknd 1286 3 was be VBD cord-010119-t1x9gknd 1286 4 tabulated tabulate VBN cord-010119-t1x9gknd 1286 5 to to TO cord-010119-t1x9gknd 1286 6 determine determine VB cord-010119-t1x9gknd 1286 7 the the DT cord-010119-t1x9gknd 1286 8 monthly monthly JJ cord-010119-t1x9gknd 1286 9 number number NN cord-010119-t1x9gknd 1286 10 of of IN cord-010119-t1x9gknd 1286 11 provider provider NN cord-010119-t1x9gknd 1286 12 - - HYPH cord-010119-t1x9gknd 1286 13 activated activate VBN cord-010119-t1x9gknd 1286 14 MTPs mtp NNS cord-010119-t1x9gknd 1286 15 , , , cord-010119-t1x9gknd 1286 16 CAT cat NN cord-010119-t1x9gknd 1286 17 - - HYPH cord-010119-t1x9gknd 1286 18 triggered trigger VBN cord-010119-t1x9gknd 1286 19 MTPs mtp NNS cord-010119-t1x9gknd 1286 20 , , , cord-010119-t1x9gknd 1286 21 and and CC cord-010119-t1x9gknd 1286 22 average average JJ cord-010119-t1x9gknd 1286 23 blood blood NN cord-010119-t1x9gknd 1286 24 component component NN cord-010119-t1x9gknd 1286 25 transfused transfuse VBN cord-010119-t1x9gknd 1286 26 per per IN cord-010119-t1x9gknd 1286 27 massive massive JJ cord-010119-t1x9gknd 1286 28 transfusion transfusion NN cord-010119-t1x9gknd 1286 29 . . . cord-010119-t1x9gknd 1287 1 Conclusion conclusion NN cord-010119-t1x9gknd 1287 2 : : : cord-010119-t1x9gknd 1287 3 Blood blood NN cord-010119-t1x9gknd 1287 4 utilization utilization NN cord-010119-t1x9gknd 1287 5 is be VBZ cord-010119-t1x9gknd 1287 6 lower low JJR cord-010119-t1x9gknd 1287 7 within within IN cord-010119-t1x9gknd 1287 8 the the DT cord-010119-t1x9gknd 1287 9 CAT cat NN cord-010119-t1x9gknd 1287 10 - - HYPH cord-010119-t1x9gknd 1287 11 triggered trigger VBN cord-010119-t1x9gknd 1287 12 MTPs mtp NNS cord-010119-t1x9gknd 1287 13 even even RB cord-010119-t1x9gknd 1287 14 though though IN cord-010119-t1x9gknd 1287 15 it -PRON- PRP cord-010119-t1x9gknd 1287 16 outnumbered outnumber VBD cord-010119-t1x9gknd 1287 17 provider provider NN cord-010119-t1x9gknd 1287 18 - - HYPH cord-010119-t1x9gknd 1287 19 activated activate VBN cord-010119-t1x9gknd 1287 20 MTPs mtp NNS cord-010119-t1x9gknd 1287 21 . . . cord-010119-t1x9gknd 1288 1 However however RB cord-010119-t1x9gknd 1288 2 , , , cord-010119-t1x9gknd 1288 3 the the DT cord-010119-t1x9gknd 1288 4 mode mode NN cord-010119-t1x9gknd 1288 5 for for IN cord-010119-t1x9gknd 1288 6 both both DT cord-010119-t1x9gknd 1288 7 groups group NNS cord-010119-t1x9gknd 1288 8 suggests suggest VBZ cord-010119-t1x9gknd 1288 9 that that IN cord-010119-t1x9gknd 1288 10 most most JJS cord-010119-t1x9gknd 1288 11 massive massive JJ cord-010119-t1x9gknd 1288 12 transfusion transfusion NN cord-010119-t1x9gknd 1288 13 require require VBP cord-010119-t1x9gknd 1288 14 less less JJR cord-010119-t1x9gknd 1288 15 blood blood NN cord-010119-t1x9gknd 1288 16 components component NNS cord-010119-t1x9gknd 1288 17 than than IN cord-010119-t1x9gknd 1288 18 the the DT cord-010119-t1x9gknd 1288 19 average average JJ cord-010119-t1x9gknd 1288 20 rate rate NN cord-010119-t1x9gknd 1288 21 . . . cord-010119-t1x9gknd 1289 1 Using use VBG cord-010119-t1x9gknd 1289 2 the the DT cord-010119-t1x9gknd 1289 3 mode mode NN cord-010119-t1x9gknd 1289 4 provides provide VBZ cord-010119-t1x9gknd 1289 5 an an DT cord-010119-t1x9gknd 1289 6 approximate approximate JJ cord-010119-t1x9gknd 1289 7 24 24 CD cord-010119-t1x9gknd 1289 8 % % NN cord-010119-t1x9gknd 1289 9 replacement replacement NN cord-010119-t1x9gknd 1289 10 of of IN cord-010119-t1x9gknd 1289 11 blood blood NN cord-010119-t1x9gknd 1289 12 volume volume NN cord-010119-t1x9gknd 1289 13 . . . cord-010119-t1x9gknd 1290 1 This this DT cord-010119-t1x9gknd 1290 2 should should MD cord-010119-t1x9gknd 1290 3 be be VB cord-010119-t1x9gknd 1290 4 enough enough JJ cord-010119-t1x9gknd 1290 5 to to TO cord-010119-t1x9gknd 1290 6 counter counter VB cord-010119-t1x9gknd 1290 7 the the DT cord-010119-t1x9gknd 1290 8 early early JJ cord-010119-t1x9gknd 1290 9 signs sign NNS cord-010119-t1x9gknd 1290 10 and and CC cord-010119-t1x9gknd 1290 11 symptoms symptom NNS cord-010119-t1x9gknd 1290 12 of of IN cord-010119-t1x9gknd 1290 13 hemorrhagic hemorrhagic JJ cord-010119-t1x9gknd 1290 14 shock shock NN cord-010119-t1x9gknd 1290 15 . . . cord-010119-t1x9gknd 1291 1 Though though IN cord-010119-t1x9gknd 1291 2 this this DT cord-010119-t1x9gknd 1291 3 study study NN cord-010119-t1x9gknd 1291 4 did do VBD cord-010119-t1x9gknd 1291 5 not not RB cord-010119-t1x9gknd 1291 6 review review VB cord-010119-t1x9gknd 1291 7 the the DT cord-010119-t1x9gknd 1291 8 appropriateness appropriateness NN cord-010119-t1x9gknd 1291 9 of of IN cord-010119-t1x9gknd 1291 10 provider provider NN cord-010119-t1x9gknd 1291 11 - - HYPH cord-010119-t1x9gknd 1291 12 activated activate VBN cord-010119-t1x9gknd 1291 13 MTPs mtp NNS cord-010119-t1x9gknd 1291 14 , , , cord-010119-t1x9gknd 1291 15 using use VBG cord-010119-t1x9gknd 1291 16 CAT cat NN cord-010119-t1x9gknd 1291 17 as as IN cord-010119-t1x9gknd 1291 18 an an DT cord-010119-t1x9gknd 1291 19 indicator indicator NN cord-010119-t1x9gknd 1291 20 ensures ensure VBZ cord-010119-t1x9gknd 1291 21 clinicians clinician NNS cord-010119-t1x9gknd 1291 22 are be VBP cord-010119-t1x9gknd 1291 23 prepared prepare VBN cord-010119-t1x9gknd 1291 24 for for IN cord-010119-t1x9gknd 1291 25 a a DT cord-010119-t1x9gknd 1291 26 potential potential JJ cord-010119-t1x9gknd 1291 27 massive massive JJ cord-010119-t1x9gknd 1291 28 transfusion transfusion NN cord-010119-t1x9gknd 1291 29 . . . cord-010119-t1x9gknd 1292 1 Further further JJ cord-010119-t1x9gknd 1292 2 investigation investigation NN cord-010119-t1x9gknd 1292 3 is be VBZ cord-010119-t1x9gknd 1292 4 needed need VBN cord-010119-t1x9gknd 1292 5 to to TO cord-010119-t1x9gknd 1292 6 determine determine VB cord-010119-t1x9gknd 1292 7 the the DT cord-010119-t1x9gknd 1292 8 factors factor NNS cord-010119-t1x9gknd 1292 9 contributing contribute VBG cord-010119-t1x9gknd 1292 10 to to IN cord-010119-t1x9gknd 1292 11 the the DT cord-010119-t1x9gknd 1292 12 downward downward JJ cord-010119-t1x9gknd 1292 13 trend trend NN cord-010119-t1x9gknd 1292 14 of of IN cord-010119-t1x9gknd 1292 15 the the DT cord-010119-t1x9gknd 1292 16 average average JJ cord-010119-t1x9gknd 1292 17 blood blood NN cord-010119-t1x9gknd 1292 18 components component NNS cord-010119-t1x9gknd 1292 19 transfused transfuse VBN cord-010119-t1x9gknd 1292 20 . . . cord-010119-t1x9gknd 1293 1 The the DT cord-010119-t1x9gknd 1293 2 mode mode NN cord-010119-t1x9gknd 1293 3 would would MD cord-010119-t1x9gknd 1293 4 suggest suggest VB cord-010119-t1x9gknd 1293 5 optimistically optimistically RB cord-010119-t1x9gknd 1293 6 that that IN cord-010119-t1x9gknd 1293 7 patients patient NNS cord-010119-t1x9gknd 1293 8 are be VBP cord-010119-t1x9gknd 1293 9 being be VBG cord-010119-t1x9gknd 1293 10 stabilized stabilize VBN cord-010119-t1x9gknd 1293 11 faster fast RBR cord-010119-t1x9gknd 1293 12 and and CC cord-010119-t1x9gknd 1293 13 resuscitated resuscitate VBD cord-010119-t1x9gknd 1293 14 more more RBR cord-010119-t1x9gknd 1293 15 efficiently efficiently RB cord-010119-t1x9gknd 1293 16 . . . cord-010119-t1x9gknd 1294 1 If if IN cord-010119-t1x9gknd 1294 2 this this DT cord-010119-t1x9gknd 1294 3 is be VBZ cord-010119-t1x9gknd 1294 4 the the DT cord-010119-t1x9gknd 1294 5 case case NN cord-010119-t1x9gknd 1294 6 , , , cord-010119-t1x9gknd 1294 7 defining define VBG cord-010119-t1x9gknd 1294 8 massive massive JJ cord-010119-t1x9gknd 1294 9 transfusion transfusion NN cord-010119-t1x9gknd 1294 10 should should MD cord-010119-t1x9gknd 1294 11 include include VB cord-010119-t1x9gknd 1294 12 the the DT cord-010119-t1x9gknd 1294 13 rate rate NN cord-010119-t1x9gknd 1294 14 of of IN cord-010119-t1x9gknd 1294 15 components component NNS cord-010119-t1x9gknd 1294 16 transfused transfuse VBN cord-010119-t1x9gknd 1294 17 in in IN cord-010119-t1x9gknd 1294 18 addition addition NN cord-010119-t1x9gknd 1294 19 to to IN cord-010119-t1x9gknd 1294 20 the the DT cord-010119-t1x9gknd 1294 21 total total JJ cord-010119-t1x9gknd 1294 22 volume volume NN cord-010119-t1x9gknd 1294 23 transfused transfuse VBN cord-010119-t1x9gknd 1294 24 . . . cord-010119-t1x9gknd 1295 1 The the DT cord-010119-t1x9gknd 1295 2 Long Long NNP cord-010119-t1x9gknd 1295 3 Term Term NNP cord-010119-t1x9gknd 1295 4 Storage Storage NNP cord-010119-t1x9gknd 1295 5 Effect Effect NNP cord-010119-t1x9gknd 1295 6 of of IN cord-010119-t1x9gknd 1295 7 0.2 0.2 CD cord-010119-t1x9gknd 1295 8 M M NNP cord-010119-t1x9gknd 1295 9 Dithiothreitol Dithiothreitol NNP cord-010119-t1x9gknd 1295 10 on on IN cord-010119-t1x9gknd 1295 11 Red Red NNP cord-010119-t1x9gknd 1295 12 Cell Cell NNP cord-010119-t1x9gknd 1295 13 Antigen Antigen NNP cord-010119-t1x9gknd 1295 14 Integrity integrity NN cord-010119-t1x9gknd 1295 15 in in IN cord-010119-t1x9gknd 1295 16 Reagent Reagent NNP cord-010119-t1x9gknd 1295 17 Red Red NNP cord-010119-t1x9gknd 1295 18 Blood Blood NNP cord-010119-t1x9gknd 1295 19 Cells cell NNS cord-010119-t1x9gknd 1295 20 Heike Heike NNP cord-010119-t1x9gknd 1295 21 Carrel Carrel NNP cord-010119-t1x9gknd 1295 22 * * NFP cord-010119-t1x9gknd 1296 1 1 1 LS cord-010119-t1x9gknd 1297 1 , , , cord-010119-t1x9gknd 1297 2 Laurie Laurie NNP cord-010119-t1x9gknd 1297 3 Sutor Sutor NNP cord-010119-t1x9gknd 1297 4 1,2 1,2 CD cord-010119-t1x9gknd 1297 5 , , , cord-010119-t1x9gknd 1297 6 Germ Germ NNP cord-010119-t1x9gknd 1297 7 an an DT cord-010119-t1x9gknd 1297 8 Leparc Leparc NNP cord-010119-t1x9gknd 1297 9 3 3 CD cord-010119-t1x9gknd 1297 10 , , , cord-010119-t1x9gknd 1297 11 Marjorie Marjorie NNP cord-010119-t1x9gknd 1297 12 Doty Doty NNP cord-010119-t1x9gknd 1297 13 3 3 CD cord-010119-t1x9gknd 1297 14 and and CC cord-010119-t1x9gknd 1297 15 William William NNP cord-010119-t1x9gknd 1297 16 Crews Crews NNP cord-010119-t1x9gknd 1297 17 1 1 CD cord-010119-t1x9gknd 1297 18 . . . cord-010119-t1x9gknd 1298 1 1 1 CD cord-010119-t1x9gknd 1298 2 Carter Carter NNP cord-010119-t1x9gknd 1298 3 BloodCare BloodCare NNP cord-010119-t1x9gknd 1298 4 , , , cord-010119-t1x9gknd 1298 5 2 2 CD cord-010119-t1x9gknd 1298 6 UT UT NNP cord-010119-t1x9gknd 1298 7 Southwestern Southwestern NNP cord-010119-t1x9gknd 1298 8 Medical Medical NNP cord-010119-t1x9gknd 1298 9 Center Center NNP cord-010119-t1x9gknd 1298 10 , , , cord-010119-t1x9gknd 1298 11 3 3 CD cord-010119-t1x9gknd 1298 12 OneBlood OneBlood NNP cord-010119-t1x9gknd 1298 13 Background Background NNP cord-010119-t1x9gknd 1298 14 / / SYM cord-010119-t1x9gknd 1298 15 Case Case NNP cord-010119-t1x9gknd 1298 16 Studies Studies NNPS cord-010119-t1x9gknd 1298 17 : : : cord-010119-t1x9gknd 1298 18 Anti anti JJ cord-010119-t1x9gknd 1298 19 - - JJ cord-010119-t1x9gknd 1298 20 CD38 cd38 JJ cord-010119-t1x9gknd 1298 21 drugs drug NNS cord-010119-t1x9gknd 1298 22 , , , cord-010119-t1x9gknd 1298 23 such such JJ cord-010119-t1x9gknd 1298 24 as as IN cord-010119-t1x9gknd 1298 25 daratumumab daratumumab NNP cord-010119-t1x9gknd 1298 26 , , , cord-010119-t1x9gknd 1298 27 pose pose VBP cord-010119-t1x9gknd 1298 28 a a DT cord-010119-t1x9gknd 1298 29 problem problem NN cord-010119-t1x9gknd 1298 30 for for IN cord-010119-t1x9gknd 1298 31 the the DT cord-010119-t1x9gknd 1298 32 transfusion transfusion NN cord-010119-t1x9gknd 1298 33 service service NN cord-010119-t1x9gknd 1298 34 . . . cord-010119-t1x9gknd 1299 1 They -PRON- PRP cord-010119-t1x9gknd 1299 2 may may MD cord-010119-t1x9gknd 1299 3 cause cause VB cord-010119-t1x9gknd 1299 4 a a DT cord-010119-t1x9gknd 1299 5 number number NN cord-010119-t1x9gknd 1299 6 of of IN cord-010119-t1x9gknd 1299 7 false false JJ cord-010119-t1x9gknd 1299 8 positives positive NNS cord-010119-t1x9gknd 1299 9 , , , cord-010119-t1x9gknd 1299 10 including include VBG cord-010119-t1x9gknd 1299 11 positive positive JJ cord-010119-t1x9gknd 1299 12 direct direct JJ cord-010119-t1x9gknd 1299 13 antiglobulin antiglobulin NN cord-010119-t1x9gknd 1299 14 tests test NNS cord-010119-t1x9gknd 1299 15 ( ( -LRB- cord-010119-t1x9gknd 1299 16 DAT DAT NNP cord-010119-t1x9gknd 1299 17 ) ) -RRB- cord-010119-t1x9gknd 1299 18 , , , cord-010119-t1x9gknd 1299 19 indirect indirect JJ cord-010119-t1x9gknd 1299 20 antiglobulin antiglobulin NN cord-010119-t1x9gknd 1299 21 tests test NNS cord-010119-t1x9gknd 1299 22 ( ( -LRB- cord-010119-t1x9gknd 1299 23 IAT IAT NNP cord-010119-t1x9gknd 1299 24 ) ) -RRB- cord-010119-t1x9gknd 1299 25 , , , cord-010119-t1x9gknd 1299 26 and and CC cord-010119-t1x9gknd 1299 27 panreactivity panreactivity NN cord-010119-t1x9gknd 1299 28 in in IN cord-010119-t1x9gknd 1299 29 eluates eluate NNS cord-010119-t1x9gknd 1299 30 . . . cord-010119-t1x9gknd 1300 1 Such such JJ cord-010119-t1x9gknd 1300 2 results result NNS cord-010119-t1x9gknd 1300 3 can can MD cord-010119-t1x9gknd 1300 4 prolong prolong VB cord-010119-t1x9gknd 1300 5 compatibility compatibility NN cord-010119-t1x9gknd 1300 6 testing testing NN cord-010119-t1x9gknd 1300 7 and and CC cord-010119-t1x9gknd 1300 8 delay delay NN cord-010119-t1x9gknd 1300 9 delivery delivery NN cord-010119-t1x9gknd 1300 10 of of IN cord-010119-t1x9gknd 1300 11 blood blood NN cord-010119-t1x9gknd 1300 12 products product NNS cord-010119-t1x9gknd 1300 13 for for IN cord-010119-t1x9gknd 1300 14 patients patient NNS cord-010119-t1x9gknd 1300 15 . . . cord-010119-t1x9gknd 1301 1 Treating treat VBG cord-010119-t1x9gknd 1301 2 reagent reagent JJ cord-010119-t1x9gknd 1301 3 red red JJ cord-010119-t1x9gknd 1301 4 cells cell NNS cord-010119-t1x9gknd 1301 5 ( ( -LRB- cord-010119-t1x9gknd 1301 6 rRBCs rRBCs NNP cord-010119-t1x9gknd 1301 7 ) ) -RRB- cord-010119-t1x9gknd 1301 8 with with IN cord-010119-t1x9gknd 1301 9 0.2 0.2 CD cord-010119-t1x9gknd 1301 10 M m NN cord-010119-t1x9gknd 1301 11 dithiothreitol dithiothreitol NN cord-010119-t1x9gknd 1301 12 ( ( -LRB- cord-010119-t1x9gknd 1301 13 DTT DTT NNP cord-010119-t1x9gknd 1301 14 ) ) -RRB- cord-010119-t1x9gknd 1301 15 removes remove VBZ cord-010119-t1x9gknd 1301 16 drug drug NN cord-010119-t1x9gknd 1301 17 interference interference NN cord-010119-t1x9gknd 1301 18 due due IN cord-010119-t1x9gknd 1301 19 to to IN cord-010119-t1x9gknd 1301 20 daratumumab daratumumab NNP cord-010119-t1x9gknd 1301 21 and and CC cord-010119-t1x9gknd 1301 22 allows allow VBZ cord-010119-t1x9gknd 1301 23 for for IN cord-010119-t1x9gknd 1301 24 the the DT cord-010119-t1x9gknd 1301 25 detection detection NN cord-010119-t1x9gknd 1301 26 of of IN cord-010119-t1x9gknd 1301 27 underlying underlie VBG cord-010119-t1x9gknd 1301 28 alloantibodies alloantibody NNS cord-010119-t1x9gknd 1301 29 . . . cord-010119-t1x9gknd 1302 1 This this DT cord-010119-t1x9gknd 1302 2 study study NN cord-010119-t1x9gknd 1302 3 aimed aim VBD cord-010119-t1x9gknd 1302 4 to to TO cord-010119-t1x9gknd 1302 5 investigate investigate VB cord-010119-t1x9gknd 1302 6 the the DT cord-010119-t1x9gknd 1302 7 effect effect NN cord-010119-t1x9gknd 1302 8 of of IN cord-010119-t1x9gknd 1302 9 DTT dtt NN cord-010119-t1x9gknd 1302 10 - - HYPH cord-010119-t1x9gknd 1302 11 treatment treatment NN cord-010119-t1x9gknd 1302 12 on on IN cord-010119-t1x9gknd 1302 13 rRBC rrbc JJ cord-010119-t1x9gknd 1302 14 antigen antigen NN cord-010119-t1x9gknd 1302 15 integrity integrity NN cord-010119-t1x9gknd 1302 16 over over IN cord-010119-t1x9gknd 1302 17 a a DT cord-010119-t1x9gknd 1302 18 28 28 CD cord-010119-t1x9gknd 1302 19 day day NN cord-010119-t1x9gknd 1302 20 period period NN cord-010119-t1x9gknd 1302 21 . . . cord-010119-t1x9gknd 1303 1 Study Study NNP cord-010119-t1x9gknd 1303 2 Design Design NNP cord-010119-t1x9gknd 1303 3 / / SYM cord-010119-t1x9gknd 1303 4 Method method NN cord-010119-t1x9gknd 1303 5 : : : cord-010119-t1x9gknd 1304 1 Twelve twelve CD cord-010119-t1x9gknd 1304 2 aliquots aliquot NNS cord-010119-t1x9gknd 1304 3 of of IN cord-010119-t1x9gknd 1304 4 human human JJ cord-010119-t1x9gknd 1304 5 plasma plasma NN cord-010119-t1x9gknd 1304 6 , , , cord-010119-t1x9gknd 1304 7 each each DT cord-010119-t1x9gknd 1304 8 containing contain VBG cord-010119-t1x9gknd 1304 9 an an DT cord-010119-t1x9gknd 1304 10 antibody antibody NN cord-010119-t1x9gknd 1304 11 of of IN cord-010119-t1x9gknd 1304 12 a a DT cord-010119-t1x9gknd 1304 13 single single JJ cord-010119-t1x9gknd 1304 14 , , , cord-010119-t1x9gknd 1304 15 known know VBN cord-010119-t1x9gknd 1304 16 specificity specificity NN cord-010119-t1x9gknd 1304 17 ( ( -LRB- cord-010119-t1x9gknd 1304 18 anti anti JJ cord-010119-t1x9gknd 1304 19 - - JJ cord-010119-t1x9gknd 1304 20 D d JJ cord-010119-t1x9gknd 1304 21 , , , cord-010119-t1x9gknd 1304 22 -C -C VBZ cord-010119-t1x9gknd 1304 23 , , , cord-010119-t1x9gknd 1304 24 -E -E JJS cord-010119-t1x9gknd 1304 25 , , , cord-010119-t1x9gknd 1304 26 -c -c : cord-010119-t1x9gknd 1304 27 , , , cord-010119-t1x9gknd 1304 28 -e -e NNP cord-010119-t1x9gknd 1304 29 , , , cord-010119-t1x9gknd 1304 30 -M -M : cord-010119-t1x9gknd 1304 31 , , , cord-010119-t1x9gknd 1304 32 -S -S HYPH cord-010119-t1x9gknd 1304 33 , , , cord-010119-t1x9gknd 1304 34 -s -s XX cord-010119-t1x9gknd 1304 35 , , , cord-010119-t1x9gknd 1304 36 -Fy -Fy NNP cord-010119-t1x9gknd 1304 37 a a DT cord-010119-t1x9gknd 1304 38 , , , cord-010119-t1x9gknd 1304 39 -Fy -Fy NNP cord-010119-t1x9gknd 1304 40 b b NN cord-010119-t1x9gknd 1304 41 , , , cord-010119-t1x9gknd 1305 1 -Jk -jk VB cord-010119-t1x9gknd 1305 2 a a DT cord-010119-t1x9gknd 1305 3 , , , cord-010119-t1x9gknd 1305 4 and and CC cord-010119-t1x9gknd 1305 5 -Jk -jk NN cord-010119-t1x9gknd 1305 6 b b LS cord-010119-t1x9gknd 1305 7 ) ) -RRB- cord-010119-t1x9gknd 1305 8 , , , cord-010119-t1x9gknd 1305 9 were be VBD cord-010119-t1x9gknd 1305 10 tested test VBN cord-010119-t1x9gknd 1305 11 against against IN cord-010119-t1x9gknd 1305 12 untreated untreated JJ cord-010119-t1x9gknd 1305 13 and and CC cord-010119-t1x9gknd 1305 14 0.2 0.2 CD cord-010119-t1x9gknd 1305 15 M m CD cord-010119-t1x9gknd 1305 16 DTTtreated dtttreate VBD cord-010119-t1x9gknd 1305 17 rRBCs rRBCs NNP cord-010119-t1x9gknd 1306 1 ( ( -LRB- cord-010119-t1x9gknd 1306 2 Immucor Immucor NNP cord-010119-t1x9gknd 1306 3 Panoscreen Panoscreen NNP cord-010119-t1x9gknd 1306 4 I -PRON- PRP cord-010119-t1x9gknd 1306 5 , , , cord-010119-t1x9gknd 1306 6 II II NNP cord-010119-t1x9gknd 1306 7 , , , cord-010119-t1x9gknd 1306 8 III III NNP cord-010119-t1x9gknd 1306 9 ; ; : cord-010119-t1x9gknd 1306 10 DTT DTT NNP cord-010119-t1x9gknd 1306 11 from from IN cord-010119-t1x9gknd 1306 12 Acros Acros NNP cord-010119-t1x9gknd 1306 13 Organics Organics NNP cord-010119-t1x9gknd 1306 14 ) ) -RRB- cord-010119-t1x9gknd 1306 15 . . . cord-010119-t1x9gknd 1307 1 DTT DTT NNP cord-010119-t1x9gknd 1307 2 treatment treatment NN cord-010119-t1x9gknd 1307 3 of of IN cord-010119-t1x9gknd 1307 4 rRBCs rRBCs NNP cord-010119-t1x9gknd 1307 5 was be VBD cord-010119-t1x9gknd 1307 6 performed perform VBN cord-010119-t1x9gknd 1307 7 using use VBG cord-010119-t1x9gknd 1307 8 the the DT cord-010119-t1x9gknd 1307 9 methodology methodology NN cord-010119-t1x9gknd 1307 10 described describe VBN cord-010119-t1x9gknd 1307 11 in in IN cord-010119-t1x9gknd 1307 12 the the DT cord-010119-t1x9gknd 1307 13 AABB AABB NNP cord-010119-t1x9gknd 1307 14 Technical Technical NNP cord-010119-t1x9gknd 1307 15 Manual Manual NNP cord-010119-t1x9gknd 1307 16 ( ( -LRB- cord-010119-t1x9gknd 1307 17 18 18 CD cord-010119-t1x9gknd 1307 18 th th XX cord-010119-t1x9gknd 1307 19 edition edition NN cord-010119-t1x9gknd 1307 20 ) ) -RRB- cord-010119-t1x9gknd 1307 21 . . . cord-010119-t1x9gknd 1308 1 Each each DT cord-010119-t1x9gknd 1308 2 of of IN cord-010119-t1x9gknd 1308 3 the the DT cord-010119-t1x9gknd 1308 4 12 12 CD cord-010119-t1x9gknd 1308 5 plasma plasma NN cord-010119-t1x9gknd 1308 6 aliquots aliquot NNS cord-010119-t1x9gknd 1308 7 was be VBD cord-010119-t1x9gknd 1308 8 further further RB cord-010119-t1x9gknd 1308 9 separated separate VBN cord-010119-t1x9gknd 1308 10 into into IN cord-010119-t1x9gknd 1308 11 28 28 CD cord-010119-t1x9gknd 1308 12 aliquots aliquot NNS cord-010119-t1x9gknd 1308 13 and and CC cord-010119-t1x9gknd 1308 14 stored store VBN cord-010119-t1x9gknd 1308 15 at at IN cord-010119-t1x9gknd 1308 16 -208C -208C NNP cord-010119-t1x9gknd 1308 17 until until IN cord-010119-t1x9gknd 1308 18 day day NN cord-010119-t1x9gknd 1308 19 of of IN cord-010119-t1x9gknd 1308 20 use use NN cord-010119-t1x9gknd 1308 21 . . . cord-010119-t1x9gknd 1309 1 Fresh fresh JJ cord-010119-t1x9gknd 1309 2 aliquots aliquot NNS cord-010119-t1x9gknd 1309 3 were be VBD cord-010119-t1x9gknd 1309 4 thawed thaw VBN cord-010119-t1x9gknd 1309 5 each each DT cord-010119-t1x9gknd 1309 6 day day NN cord-010119-t1x9gknd 1309 7 to to TO cord-010119-t1x9gknd 1309 8 avoid avoid VB cord-010119-t1x9gknd 1309 9 unintended unintended JJ cord-010119-t1x9gknd 1309 10 antibody antibody NN cord-010119-t1x9gknd 1309 11 integrity integrity NN cord-010119-t1x9gknd 1309 12 degradation degradation NN cord-010119-t1x9gknd 1309 13 . . . cord-010119-t1x9gknd 1310 1 A a DT cord-010119-t1x9gknd 1310 2 Polyethylene Polyethylene NNP cord-010119-t1x9gknd 1310 3 Glycol Glycol NNP cord-010119-t1x9gknd 1310 4 ( ( -LRB- cord-010119-t1x9gknd 1310 5 Immucor Immucor NNP cord-010119-t1x9gknd 1310 6 ) ) -RRB- cord-010119-t1x9gknd 1310 7 enhancement enhancement NN cord-010119-t1x9gknd 1310 8 technique technique NN cord-010119-t1x9gknd 1310 9 was be VBD cord-010119-t1x9gknd 1310 10 used use VBN cord-010119-t1x9gknd 1310 11 and and CC cord-010119-t1x9gknd 1310 12 reactions reaction NNS cord-010119-t1x9gknd 1310 13 were be VBD cord-010119-t1x9gknd 1310 14 read read VBN cord-010119-t1x9gknd 1310 15 at at IN cord-010119-t1x9gknd 1310 16 the the DT cord-010119-t1x9gknd 1310 17 IAT IAT NNP cord-010119-t1x9gknd 1310 18 phase phase NN cord-010119-t1x9gknd 1310 19 . . . cord-010119-t1x9gknd 1311 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 1311 2 , , , cord-010119-t1x9gknd 1311 3 if if IN cord-010119-t1x9gknd 1311 4 present present JJ cord-010119-t1x9gknd 1311 5 , , , cord-010119-t1x9gknd 1311 6 was be VBD cord-010119-t1x9gknd 1311 7 observed observe VBN cord-010119-t1x9gknd 1311 8 in in IN cord-010119-t1x9gknd 1311 9 the the DT cord-010119-t1x9gknd 1311 10 diluent diluent NN cord-010119-t1x9gknd 1311 11 each each DT cord-010119-t1x9gknd 1311 12 day day NN cord-010119-t1x9gknd 1311 13 prior prior RB cord-010119-t1x9gknd 1311 14 to to IN cord-010119-t1x9gknd 1311 15 mixing mix VBG cord-010119-t1x9gknd 1311 16 the the DT cord-010119-t1x9gknd 1311 17 cell cell NN cord-010119-t1x9gknd 1311 18 suspension suspension NN cord-010119-t1x9gknd 1311 19 and and CC cord-010119-t1x9gknd 1311 20 given give VBN cord-010119-t1x9gknd 1311 21 a a DT cord-010119-t1x9gknd 1311 22 grade grade NN cord-010119-t1x9gknd 1311 23 based base VBN cord-010119-t1x9gknd 1311 24 on on IN cord-010119-t1x9gknd 1311 25 the the DT cord-010119-t1x9gknd 1311 26 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 1311 27 color color NN cord-010119-t1x9gknd 1311 28 comparator comparator NN cord-010119-t1x9gknd 1311 29 chart chart NN cord-010119-t1x9gknd 1311 30 . . . cord-010119-t1x9gknd 1312 1 Serological serological JJ cord-010119-t1x9gknd 1312 2 antibody antibody NN cord-010119-t1x9gknd 1312 3 reaction reaction NN cord-010119-t1x9gknd 1312 4 strengths strength NNS cord-010119-t1x9gknd 1312 5 were be VBD cord-010119-t1x9gknd 1312 6 observed observe VBN cord-010119-t1x9gknd 1312 7 and and CC cord-010119-t1x9gknd 1312 8 documented document VBD cord-010119-t1x9gknd 1312 9 each each DT cord-010119-t1x9gknd 1312 10 day day NN cord-010119-t1x9gknd 1312 11 . . . cord-010119-t1x9gknd 1313 1 ( ( -LRB- cord-010119-t1x9gknd 1313 2 25 25 CD cord-010119-t1x9gknd 1313 3 ) ) -RRB- cord-010119-t1x9gknd 1314 1 A a DT cord-010119-t1x9gknd 1314 2 monthly monthly JJ cord-010119-t1x9gknd 1314 3 breakdown breakdown NN cord-010119-t1x9gknd 1314 4 for for IN cord-010119-t1x9gknd 1314 5 both both DT cord-010119-t1x9gknd 1314 6 groups group NNS cord-010119-t1x9gknd 1314 7 also also RB cord-010119-t1x9gknd 1314 8 displayed display VBD cord-010119-t1x9gknd 1314 9 a a DT cord-010119-t1x9gknd 1314 10 downward downward JJ cord-010119-t1x9gknd 1314 11 trend trend NN cord-010119-t1x9gknd 1314 12 in in IN cord-010119-t1x9gknd 1314 13 the the DT cord-010119-t1x9gknd 1314 14 average average JJ cord-010119-t1x9gknd 1314 15 use use NN cord-010119-t1x9gknd 1314 16 of of IN cord-010119-t1x9gknd 1314 17 blood blood NN cord-010119-t1x9gknd 1314 18 components component NNS cord-010119-t1x9gknd 1314 19 . . . cord-010119-t1x9gknd 1315 1 Results/ Results/ . cord-010119-t1x9gknd 1316 1 Finding find VBG cord-010119-t1x9gknd 1316 2 : : : cord-010119-t1x9gknd 1316 3 There there EX cord-010119-t1x9gknd 1316 4 was be VBD cord-010119-t1x9gknd 1316 5 noticeably noticeably RB cord-010119-t1x9gknd 1316 6 more more JJR cord-010119-t1x9gknd 1316 7 hemolysis hemolysis NN cord-010119-t1x9gknd 1316 8 with with IN cord-010119-t1x9gknd 1316 9 the the DT cord-010119-t1x9gknd 1316 10 DTTtreated dtttreate VBN cord-010119-t1x9gknd 1316 11 cells cell NNS cord-010119-t1x9gknd 1316 12 over over IN cord-010119-t1x9gknd 1316 13 time time NN cord-010119-t1x9gknd 1316 14 compared compare VBN cord-010119-t1x9gknd 1316 15 to to IN cord-010119-t1x9gknd 1316 16 the the DT cord-010119-t1x9gknd 1316 17 untreated untreated JJ cord-010119-t1x9gknd 1316 18 cells cell NNS cord-010119-t1x9gknd 1316 19 . . . cord-010119-t1x9gknd 1317 1 Red red JJ cord-010119-t1x9gknd 1317 2 cell cell NN cord-010119-t1x9gknd 1317 3 antigens antigen NNS cord-010119-t1x9gknd 1317 4 remained remain VBD cord-010119-t1x9gknd 1317 5 serologically serologically RB cord-010119-t1x9gknd 1317 6 detectable detectable JJ cord-010119-t1x9gknd 1317 7 on on IN cord-010119-t1x9gknd 1317 8 the the DT cord-010119-t1x9gknd 1317 9 DTT dtt NN cord-010119-t1x9gknd 1317 10 - - HYPH cord-010119-t1x9gknd 1317 11 treated treat VBN cord-010119-t1x9gknd 1317 12 cells cell NNS cord-010119-t1x9gknd 1317 13 throughout throughout IN cord-010119-t1x9gknd 1317 14 the the DT cord-010119-t1x9gknd 1317 15 study study NN cord-010119-t1x9gknd 1317 16 , , , cord-010119-t1x9gknd 1317 17 despite despite IN cord-010119-t1x9gknd 1317 18 a a DT cord-010119-t1x9gknd 1317 19 greater great JJR cord-010119-t1x9gknd 1317 20 degree degree NN cord-010119-t1x9gknd 1317 21 of of IN cord-010119-t1x9gknd 1317 22 observed observed JJ cord-010119-t1x9gknd 1317 23 hemolysis hemolysis NN cord-010119-t1x9gknd 1317 24 . . . cord-010119-t1x9gknd 1318 1 There there EX cord-010119-t1x9gknd 1318 2 was be VBD cord-010119-t1x9gknd 1318 3 minimal minimal JJ cord-010119-t1x9gknd 1318 4 difference difference NN cord-010119-t1x9gknd 1318 5 in in IN cord-010119-t1x9gknd 1318 6 reactivity reactivity NN cord-010119-t1x9gknd 1318 7 strength strength NN cord-010119-t1x9gknd 1318 8 between between IN cord-010119-t1x9gknd 1318 9 untreated untreated JJ cord-010119-t1x9gknd 1318 10 and and CC cord-010119-t1x9gknd 1318 11 DTT dtt NN cord-010119-t1x9gknd 1318 12 - - HYPH cord-010119-t1x9gknd 1318 13 treated treat VBN cord-010119-t1x9gknd 1318 14 cells cell NNS cord-010119-t1x9gknd 1318 15 for for IN cord-010119-t1x9gknd 1318 16 antigens antigen NNS cord-010119-t1x9gknd 1318 17 not not RB cord-010119-t1x9gknd 1318 18 affected affect VBN cord-010119-t1x9gknd 1318 19 by by IN cord-010119-t1x9gknd 1318 20 DTT DTT NNP cord-010119-t1x9gknd 1318 21 . . . cord-010119-t1x9gknd 1319 1 In in IN cord-010119-t1x9gknd 1319 2 most most JJS cord-010119-t1x9gknd 1319 3 instances instance NNS cord-010119-t1x9gknd 1319 4 , , , cord-010119-t1x9gknd 1319 5 the the DT cord-010119-t1x9gknd 1319 6 DTT DTT NNP cord-010119-t1x9gknd 1319 7 - - HYPH cord-010119-t1x9gknd 1319 8 treated treat VBN cord-010119-t1x9gknd 1319 9 cells cell NNS cord-010119-t1x9gknd 1319 10 reacted react VBD cord-010119-t1x9gknd 1319 11 slightly slightly RB cord-010119-t1x9gknd 1319 12 more more RBR cord-010119-t1x9gknd 1319 13 strongly strongly RB cord-010119-t1x9gknd 1319 14 . . . cord-010119-t1x9gknd 1320 1 None none NN cord-010119-t1x9gknd 1320 2 of of IN cord-010119-t1x9gknd 1320 3 the the DT cord-010119-t1x9gknd 1320 4 antibodies antibody NNS cord-010119-t1x9gknd 1320 5 produced produce VBD cord-010119-t1x9gknd 1320 6 reactivity reactivity NN cord-010119-t1x9gknd 1320 7 strengths strength NNS cord-010119-t1x9gknd 1320 8 of of IN cord-010119-t1x9gknd 1320 9 less less JJR cord-010119-t1x9gknd 1320 10 than than IN cord-010119-t1x9gknd 1320 11 11 11 CD cord-010119-t1x9gknd 1320 12 with with IN cord-010119-t1x9gknd 1320 13 the the DT cord-010119-t1x9gknd 1320 14 untreated untreated JJ cord-010119-t1x9gknd 1320 15 or or CC cord-010119-t1x9gknd 1320 16 DTT dtt NN cord-010119-t1x9gknd 1320 17 - - HYPH cord-010119-t1x9gknd 1320 18 treated treat VBN cord-010119-t1x9gknd 1320 19 cells cell NNS cord-010119-t1x9gknd 1320 20 during during IN cord-010119-t1x9gknd 1320 21 the the DT cord-010119-t1x9gknd 1320 22 study study NN cord-010119-t1x9gknd 1320 23 . . . cord-010119-t1x9gknd 1321 1 Conclusion conclusion NN cord-010119-t1x9gknd 1321 2 : : : cord-010119-t1x9gknd 1322 1 Long long JJ cord-010119-t1x9gknd 1322 2 term term NN cord-010119-t1x9gknd 1322 3 storage storage NN cord-010119-t1x9gknd 1322 4 of of IN cord-010119-t1x9gknd 1322 5 0.2 0.2 CD cord-010119-t1x9gknd 1322 6 M M NNP cord-010119-t1x9gknd 1322 7 DTT DTT NNP cord-010119-t1x9gknd 1322 8 - - HYPH cord-010119-t1x9gknd 1322 9 treated treat VBN cord-010119-t1x9gknd 1322 10 rRBCs rRBCs NNP cord-010119-t1x9gknd 1322 11 does do VBZ cord-010119-t1x9gknd 1322 12 not not RB cord-010119-t1x9gknd 1322 13 compromise compromise VB cord-010119-t1x9gknd 1322 14 antigen antigen NN cord-010119-t1x9gknd 1322 15 integrity integrity NN cord-010119-t1x9gknd 1322 16 . . . cord-010119-t1x9gknd 1323 1 Advance Advance NNP cord-010119-t1x9gknd 1323 2 DTT dtt NN cord-010119-t1x9gknd 1323 3 - - HYPH cord-010119-t1x9gknd 1323 4 treatment treatment NN cord-010119-t1x9gknd 1323 5 and and CC cord-010119-t1x9gknd 1323 6 storage storage NN cord-010119-t1x9gknd 1323 7 of of IN cord-010119-t1x9gknd 1323 8 a a DT cord-010119-t1x9gknd 1323 9 large large JJ cord-010119-t1x9gknd 1323 10 aliquot aliquot NN cord-010119-t1x9gknd 1323 11 of of IN cord-010119-t1x9gknd 1323 12 rRBCs rRBCs `` cord-010119-t1x9gknd 1323 13 may may MD cord-010119-t1x9gknd 1323 14 serve serve VB cord-010119-t1x9gknd 1323 15 to to TO cord-010119-t1x9gknd 1323 16 increase increase VB cord-010119-t1x9gknd 1323 17 efficiency efficiency NN cord-010119-t1x9gknd 1323 18 in in IN cord-010119-t1x9gknd 1323 19 the the DT cord-010119-t1x9gknd 1323 20 transfusion transfusion NN cord-010119-t1x9gknd 1323 21 service service NN cord-010119-t1x9gknd 1323 22 . . . cord-010119-t1x9gknd 1324 1 Background Background NNP cord-010119-t1x9gknd 1324 2 / / SYM cord-010119-t1x9gknd 1324 3 Case Case NNP cord-010119-t1x9gknd 1324 4 Studies Studies NNPS cord-010119-t1x9gknd 1324 5 : : : cord-010119-t1x9gknd 1324 6 Monocyte Monocyte NNP cord-010119-t1x9gknd 1324 7 monolayer monolayer NN cord-010119-t1x9gknd 1324 8 assay assay NN cord-010119-t1x9gknd 1324 9 ( ( -LRB- cord-010119-t1x9gknd 1324 10 MMA MMA NNP cord-010119-t1x9gknd 1324 11 ) ) -RRB- cord-010119-t1x9gknd 1324 12 is be VBZ cord-010119-t1x9gknd 1324 13 a a DT cord-010119-t1x9gknd 1324 14 cellular cellular JJ cord-010119-t1x9gknd 1324 15 bioassay bioassay NN cord-010119-t1x9gknd 1324 16 used use VBN cord-010119-t1x9gknd 1324 17 to to TO cord-010119-t1x9gknd 1324 18 evaluate evaluate VB cord-010119-t1x9gknd 1324 19 the the DT cord-010119-t1x9gknd 1324 20 hemolytic hemolytic JJ cord-010119-t1x9gknd 1324 21 significance significance NN cord-010119-t1x9gknd 1324 22 of of IN cord-010119-t1x9gknd 1324 23 blood blood NN cord-010119-t1x9gknd 1324 24 group group NN cord-010119-t1x9gknd 1324 25 antibodies antibody NNS cord-010119-t1x9gknd 1324 26 and and CC cord-010119-t1x9gknd 1324 27 aid aid NN cord-010119-t1x9gknd 1324 28 in in IN cord-010119-t1x9gknd 1324 29 the the DT cord-010119-t1x9gknd 1324 30 selection selection NN cord-010119-t1x9gknd 1324 31 of of IN cord-010119-t1x9gknd 1324 32 RBCs rbc NNS cord-010119-t1x9gknd 1324 33 for for IN cord-010119-t1x9gknd 1324 34 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 1324 35 patients patient NNS cord-010119-t1x9gknd 1324 36 . . . cord-010119-t1x9gknd 1325 1 The the DT cord-010119-t1x9gknd 1325 2 requirement requirement NN cord-010119-t1x9gknd 1325 3 for for IN cord-010119-t1x9gknd 1325 4 fresh fresh JJ cord-010119-t1x9gknd 1325 5 auto auto NN cord-010119-t1x9gknd 1325 6 / / SYM cord-010119-t1x9gknd 1325 7 allogenic allogenic NN cord-010119-t1x9gknd 1325 8 monocytes monocyte NNS cord-010119-t1x9gknd 1325 9 for for IN cord-010119-t1x9gknd 1325 10 MMA MMA NNP cord-010119-t1x9gknd 1325 11 is be VBZ cord-010119-t1x9gknd 1325 12 highly highly RB cord-010119-t1x9gknd 1325 13 restrictive restrictive JJ cord-010119-t1x9gknd 1325 14 due due IN cord-010119-t1x9gknd 1325 15 to to IN cord-010119-t1x9gknd 1325 16 tedious tedious JJ cord-010119-t1x9gknd 1325 17 processing processing NN cord-010119-t1x9gknd 1325 18 of of IN cord-010119-t1x9gknd 1325 19 fresh fresh JJ cord-010119-t1x9gknd 1325 20 peripheral peripheral JJ cord-010119-t1x9gknd 1325 21 blood blood NN cord-010119-t1x9gknd 1325 22 ( ( -LRB- cord-010119-t1x9gknd 1325 23 PB PB NNP cord-010119-t1x9gknd 1325 24 ) ) -RRB- cord-010119-t1x9gknd 1325 25 . . . cord-010119-t1x9gknd 1326 1 Our -PRON- PRP$ cord-010119-t1x9gknd 1326 2 previous previous JJ cord-010119-t1x9gknd 1326 3 study study NN cord-010119-t1x9gknd 1326 4 described describe VBD cord-010119-t1x9gknd 1326 5 processing processing NN cord-010119-t1x9gknd 1326 6 and and CC cord-010119-t1x9gknd 1326 7 cryopreservation cryopreservation NN cord-010119-t1x9gknd 1326 8 of of IN cord-010119-t1x9gknd 1326 9 buffy buffy NNP cord-010119-t1x9gknd 1326 10 - - HYPH cord-010119-t1x9gknd 1326 11 coat coat NNP cord-010119-t1x9gknd 1326 12 ( ( -LRB- cord-010119-t1x9gknd 1326 13 BC BC NNP cord-010119-t1x9gknd 1326 14 ) ) -RRB- cord-010119-t1x9gknd 1326 15 derived derive VBN cord-010119-t1x9gknd 1326 16 and and CC cord-010119-t1x9gknd 1326 17 fresh fresh JJ cord-010119-t1x9gknd 1326 18 PB pb NN cord-010119-t1x9gknd 1326 19 - - HYPH cord-010119-t1x9gknd 1326 20 monocytes monocyte NNS cord-010119-t1x9gknd 1326 21 for for IN cord-010119-t1x9gknd 1326 22 MMA MMA NNP cord-010119-t1x9gknd 1326 23 assay assay NN cord-010119-t1x9gknd 1326 24 . . . cord-010119-t1x9gknd 1327 1 The the DT cord-010119-t1x9gknd 1327 2 aim aim NN cord-010119-t1x9gknd 1327 3 was be VBD cord-010119-t1x9gknd 1327 4 to to TO cord-010119-t1x9gknd 1327 5 evaluate evaluate VB cord-010119-t1x9gknd 1327 6 the the DT cord-010119-t1x9gknd 1327 7 functional functional JJ cord-010119-t1x9gknd 1327 8 properties property NNS cord-010119-t1x9gknd 1327 9 of of IN cord-010119-t1x9gknd 1327 10 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 1327 11 BC BC NNP cord-010119-t1x9gknd 1327 12 - - HYPH cord-010119-t1x9gknd 1327 13 monocytes monocyte NNS cord-010119-t1x9gknd 1327 14 as as IN cord-010119-t1x9gknd 1327 15 substitute substitute NN cord-010119-t1x9gknd 1327 16 for for IN cord-010119-t1x9gknd 1327 17 fresh fresh JJ cord-010119-t1x9gknd 1327 18 PBmonocytes PBmonocytes NNP cord-010119-t1x9gknd 1327 19 in in IN cord-010119-t1x9gknd 1327 20 MMA MMA NNP cord-010119-t1x9gknd 1327 21 in in IN cord-010119-t1x9gknd 1327 22 evaluation evaluation NN cord-010119-t1x9gknd 1327 23 of of IN cord-010119-t1x9gknd 1327 24 previously previously RB cord-010119-t1x9gknd 1327 25 reported report VBN cord-010119-t1x9gknd 1327 26 clinically clinically RB cord-010119-t1x9gknd 1327 27 significant significant JJ cord-010119-t1x9gknd 1327 28 RBC RBC NNP cord-010119-t1x9gknd 1327 29 alloantibodies alloantibody NNS cord-010119-t1x9gknd 1327 30 . . . cord-010119-t1x9gknd 1328 1 Study Study NNP cord-010119-t1x9gknd 1328 2 Design Design NNP cord-010119-t1x9gknd 1328 3 / / SYM cord-010119-t1x9gknd 1328 4 Methods method NNS cord-010119-t1x9gknd 1328 5 : : : cord-010119-t1x9gknd 1329 1 Peripheral peripheral JJ cord-010119-t1x9gknd 1329 2 blood blood NN cord-010119-t1x9gknd 1329 3 mononuclear mononuclear NN cord-010119-t1x9gknd 1329 4 cells cell NNS cord-010119-t1x9gknd 1329 5 ( ( -LRB- cord-010119-t1x9gknd 1329 6 PBMCs pbmc NNS cord-010119-t1x9gknd 1329 7 ) ) -RRB- cord-010119-t1x9gknd 1329 8 were be VBD cord-010119-t1x9gknd 1329 9 isolated isolate VBN cord-010119-t1x9gknd 1329 10 from from IN cord-010119-t1x9gknd 1329 11 buffy buffy NNP cord-010119-t1x9gknd 1329 12 - - HYPH cord-010119-t1x9gknd 1329 13 coats coat NNS cord-010119-t1x9gknd 1329 14 ( ( -LRB- cord-010119-t1x9gknd 1329 15 Histopaque-10771 Histopaque-10771 NNP cord-010119-t1x9gknd 1329 16 ) ) -RRB- cord-010119-t1x9gknd 1329 17 , , , cord-010119-t1x9gknd 1329 18 pooled pool VBN cord-010119-t1x9gknd 1329 19 , , , cord-010119-t1x9gknd 1329 20 suspended suspend VBN cord-010119-t1x9gknd 1329 21 in in IN cord-010119-t1x9gknd 1329 22 cryopreservation cryopreservation NN cord-010119-t1x9gknd 1329 23 media medium NNS cord-010119-t1x9gknd 1329 24 ( ( -LRB- cord-010119-t1x9gknd 1329 25 20 20 CD cord-010119-t1x9gknd 1329 26 % % NN cord-010119-t1x9gknd 1329 27 DMSO DMSO NNP cord-010119-t1x9gknd 1329 28 ; ; : cord-010119-t1x9gknd 1329 29 1:1 1:1 LS cord-010119-t1x9gknd 1329 30 ) ) -RRB- cord-010119-t1x9gknd 1329 31 and and CC cord-010119-t1x9gknd 1329 32 stored store VBN cord-010119-t1x9gknd 1329 33 in in IN cord-010119-t1x9gknd 1329 34 liquid liquid JJ cord-010119-t1x9gknd 1329 35 nitrogen nitrogen NN cord-010119-t1x9gknd 1329 36 . . . cord-010119-t1x9gknd 1330 1 PBMC PBMC NNS cord-010119-t1x9gknd 1330 2 membrane membrane NN cord-010119-t1x9gknd 1330 3 integrity integrity NN cord-010119-t1x9gknd 1330 4 post post NN cord-010119-t1x9gknd 1330 5 - - NN cord-010119-t1x9gknd 1330 6 thaw thaw NN cord-010119-t1x9gknd 1330 7 was be VBD cord-010119-t1x9gknd 1330 8 determined determine VBN cord-010119-t1x9gknd 1330 9 by by IN cord-010119-t1x9gknd 1330 10 trypan trypan NNP cord-010119-t1x9gknd 1330 11 blue blue JJ cord-010119-t1x9gknd 1330 12 exclusion exclusion NN cord-010119-t1x9gknd 1330 13 . . . cord-010119-t1x9gknd 1331 1 PBMCs pbmc NNS cord-010119-t1x9gknd 1331 2 were be VBD cord-010119-t1x9gknd 1331 3 cultured culture VBN cord-010119-t1x9gknd 1331 4 on on IN cord-010119-t1x9gknd 1331 5 poly poly NNP cord-010119-t1x9gknd 1331 6 - - HYPH cord-010119-t1x9gknd 1331 7 L l NN cord-010119-t1x9gknd 1331 8 - - HYPH cord-010119-t1x9gknd 1331 9 lysine lysine NN cord-010119-t1x9gknd 1331 10 - - HYPH cord-010119-t1x9gknd 1331 11 treated treat VBN cord-010119-t1x9gknd 1331 12 coverslips coverslip NNS cord-010119-t1x9gknd 1331 13 ( ( -LRB- cord-010119-t1x9gknd 1331 14 378C 378c CD cord-010119-t1x9gknd 1331 15 , , , cord-010119-t1x9gknd 1331 16 5 5 CD cord-010119-t1x9gknd 1331 17 % % NN cord-010119-t1x9gknd 1331 18 CO co NN cord-010119-t1x9gknd 1331 19 2 2 CD cord-010119-t1x9gknd 1331 20 , , , cord-010119-t1x9gknd 1331 21 1 1 CD cord-010119-t1x9gknd 1331 22 h h NN cord-010119-t1x9gknd 1331 23 ) ) -RRB- cord-010119-t1x9gknd 1331 24 and and CC cord-010119-t1x9gknd 1331 25 monocyte monocyte NNP cord-010119-t1x9gknd 1331 26 monolayers monolayer NNS cord-010119-t1x9gknd 1331 27 incubated incubate VBD cord-010119-t1x9gknd 1331 28 with with IN cord-010119-t1x9gknd 1331 29 fresh fresh JJ cord-010119-t1x9gknd 1331 30 or or CC cord-010119-t1x9gknd 1331 31 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 1331 32 antigen antigen NN cord-010119-t1x9gknd 1331 33 positive positive JJ cord-010119-t1x9gknd 1331 34 ( ( -LRB- cord-010119-t1x9gknd 1331 35 O1 o1 NN cord-010119-t1x9gknd 1331 36 ) ) -RRB- cord-010119-t1x9gknd 1331 37 RBCs rbc NNS cord-010119-t1x9gknd 1331 38 sensitized sensitize VBN cord-010119-t1x9gknd 1331 39 with with IN cord-010119-t1x9gknd 1331 40 either either DT cord-010119-t1x9gknd 1331 41 anti anti JJ cord-010119-t1x9gknd 1331 42 - - JJ cord-010119-t1x9gknd 1331 43 D d JJ cord-010119-t1x9gknd 1331 44 ( ( -LRB- cord-010119-t1x9gknd 1331 45 positive positive JJ cord-010119-t1x9gknd 1331 46 control control NN cord-010119-t1x9gknd 1331 47 ) ) -RRB- cord-010119-t1x9gknd 1331 48 , , , cord-010119-t1x9gknd 1331 49 anti anti NNP cord-010119-t1x9gknd 1331 50 - - NNP cord-010119-t1x9gknd 1331 51 Scianna-2 Scianna-2 NNP cord-010119-t1x9gknd 1331 52 ( ( -LRB- cord-010119-t1x9gknd 1331 53 Sc2 Sc2 NNP cord-010119-t1x9gknd 1331 54 ) ) -RRB- cord-010119-t1x9gknd 1331 55 or or CC cord-010119-t1x9gknd 1331 56 anti anti JJ cord-010119-t1x9gknd 1331 57 - - JJ cord-010119-t1x9gknd 1331 58 AnWj anwj JJ cord-010119-t1x9gknd 1331 59 or or CC cord-010119-t1x9gknd 1331 60 lipopolysaccharide lipopolysaccharide NN cord-010119-t1x9gknd 1331 61 stimulated stimulate VBD cord-010119-t1x9gknd 1331 62 for for IN cord-010119-t1x9gknd 1331 63 2 2 CD cord-010119-t1x9gknd 1331 64 h. h. NNP cord-010119-t1x9gknd 1331 65 Aliquots Aliquots NNP cord-010119-t1x9gknd 1331 66 of of IN cord-010119-t1x9gknd 1331 67 the the DT cord-010119-t1x9gknd 1331 68 sensitized sensitize VBN cord-010119-t1x9gknd 1331 69 RBCs rbc NNS cord-010119-t1x9gknd 1331 70 were be VBD cord-010119-t1x9gknd 1331 71 tested test VBN cord-010119-t1x9gknd 1331 72 for for IN cord-010119-t1x9gknd 1331 73 opsonization opsonization NN cord-010119-t1x9gknd 1331 74 by by IN cord-010119-t1x9gknd 1331 75 indirect indirect JJ cord-010119-t1x9gknd 1331 76 antiglobulin antiglobulin NN cord-010119-t1x9gknd 1331 77 test test NN cord-010119-t1x9gknd 1331 78 ( ( -LRB- cord-010119-t1x9gknd 1331 79 IAT IAT NNP cord-010119-t1x9gknd 1331 80 ) ) -RRB- cord-010119-t1x9gknd 1331 81 . . . cord-010119-t1x9gknd 1332 1 Phagocytosis Phagocytosis NNP cord-010119-t1x9gknd 1332 2 index index NN cord-010119-t1x9gknd 1332 3 ( ( -LRB- cord-010119-t1x9gknd 1332 4 PI PI NNP cord-010119-t1x9gknd 1332 5 ) ) -RRB- cord-010119-t1x9gknd 1332 6 was be VBD cord-010119-t1x9gknd 1332 7 determined determine VBN cord-010119-t1x9gknd 1332 8 microscopically microscopically RB cord-010119-t1x9gknd 1332 9 as as IN cord-010119-t1x9gknd 1332 10 the the DT cord-010119-t1x9gknd 1332 11 number number NN cord-010119-t1x9gknd 1332 12 of of IN cord-010119-t1x9gknd 1332 13 fully fully RB cord-010119-t1x9gknd 1332 14 phagocytosed phagocytose VBN cord-010119-t1x9gknd 1332 15 RBCs/100 rbcs/100 PRP$ cord-010119-t1x9gknd 1332 16 monocytes monocyte NNS cord-010119-t1x9gknd 1332 17 . . . cord-010119-t1x9gknd 1333 1 Supernatants supernatant NNS cord-010119-t1x9gknd 1333 2 were be VBD cord-010119-t1x9gknd 1333 3 analyzed analyze VBN cord-010119-t1x9gknd 1333 4 for for IN cord-010119-t1x9gknd 1333 5 cytokines cytokine NNS cord-010119-t1x9gknd 1333 6 using use VBG cord-010119-t1x9gknd 1333 7 Luminex Luminex NNP cord-010119-t1x9gknd 1333 8 technique technique NN cord-010119-t1x9gknd 1333 9 . . . cord-010119-t1x9gknd 1334 1 Results result NNS cord-010119-t1x9gknd 1334 2 / / SYM cord-010119-t1x9gknd 1334 3 Findings finding NNS cord-010119-t1x9gknd 1334 4 : : : cord-010119-t1x9gknd 1335 1 Cryopreserved Cryopreserved NNP cord-010119-t1x9gknd 1335 2 PBMCs pbmc NNS cord-010119-t1x9gknd 1335 3 showed show VBD cord-010119-t1x9gknd 1335 4 96.2 96.2 CD cord-010119-t1x9gknd 1335 5 6 6 CD cord-010119-t1x9gknd 1335 6 1 1 CD cord-010119-t1x9gknd 1335 7 % % NN cord-010119-t1x9gknd 1335 8 viability viability NN cord-010119-t1x9gknd 1335 9 postthaw postthaw NNP cord-010119-t1x9gknd 1335 10 . . . cord-010119-t1x9gknd 1336 1 We -PRON- PRP cord-010119-t1x9gknd 1336 2 report report VBP cord-010119-t1x9gknd 1336 3 no no DT cord-010119-t1x9gknd 1336 4 significant significant JJ cord-010119-t1x9gknd 1336 5 difference difference NN cord-010119-t1x9gknd 1336 6 in in IN cord-010119-t1x9gknd 1336 7 phagocytosis phagocytosis NN cord-010119-t1x9gknd 1336 8 of of IN cord-010119-t1x9gknd 1336 9 anti anti JJ cord-010119-t1x9gknd 1336 10 - - JJ cord-010119-t1x9gknd 1336 11 D d JJ cord-010119-t1x9gknd 1336 12 sensitized sensitize VBN cord-010119-t1x9gknd 1336 13 RBCs rbc NNS cord-010119-t1x9gknd 1336 14 by by IN cord-010119-t1x9gknd 1336 15 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 1336 16 monocytes monocyte NNS cord-010119-t1x9gknd 1336 17 vs vs IN cord-010119-t1x9gknd 1336 18 fresh fresh JJ cord-010119-t1x9gknd 1336 19 monocytes monocyte NNS cord-010119-t1x9gknd 1336 20 . . . cord-010119-t1x9gknd 1337 1 We -PRON- PRP cord-010119-t1x9gknd 1337 2 show show VBP cord-010119-t1x9gknd 1337 3 a a DT cord-010119-t1x9gknd 1337 4 significant significant JJ cord-010119-t1x9gknd 1337 5 increase increase NN cord-010119-t1x9gknd 1337 6 in in IN cord-010119-t1x9gknd 1337 7 TNF TNF NNP cord-010119-t1x9gknd 1337 8 - - HYPH cord-010119-t1x9gknd 1337 9 a a NNP cord-010119-t1x9gknd 1337 10 , , , cord-010119-t1x9gknd 1337 11 IL-1b IL-1b NNP cord-010119-t1x9gknd 1337 12 , , , cord-010119-t1x9gknd 1337 13 IL-6 IL-6 NNP cord-010119-t1x9gknd 1337 14 , , , cord-010119-t1x9gknd 1337 15 IL-8 IL-8 NNP cord-010119-t1x9gknd 1337 16 , , , cord-010119-t1x9gknd 1337 17 MIP MIP NNP cord-010119-t1x9gknd 1337 18 - - HYPH cord-010119-t1x9gknd 1337 19 a a NN cord-010119-t1x9gknd 1337 20 ( ( -LRB- cord-010119-t1x9gknd 1337 21 p p NN cord-010119-t1x9gknd 1337 22 < < XX cord-010119-t1x9gknd 1337 23 0.01 0.01 CD cord-010119-t1x9gknd 1337 24 ) ) -RRB- cord-010119-t1x9gknd 1337 25 , , , cord-010119-t1x9gknd 1337 26 MIP MIP NNP cord-010119-t1x9gknd 1337 27 - - HYPH cord-010119-t1x9gknd 1337 28 b b NNP cord-010119-t1x9gknd 1337 29 and and CC cord-010119-t1x9gknd 1337 30 GRO GRO NNP cord-010119-t1x9gknd 1337 31 ( ( -LRB- cord-010119-t1x9gknd 1337 32 p p NN cord-010119-t1x9gknd 1337 33 < < XX cord-010119-t1x9gknd 1337 34 0.05 0.05 CD cord-010119-t1x9gknd 1337 35 ) ) -RRB- cord-010119-t1x9gknd 1337 36 secretion secretion NN cord-010119-t1x9gknd 1337 37 from from IN cord-010119-t1x9gknd 1337 38 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 1337 39 BC BC NNP cord-010119-t1x9gknd 1337 40 monocytes monocyte NNS cord-010119-t1x9gknd 1337 41 vs vs IN cord-010119-t1x9gknd 1337 42 both both CC cord-010119-t1x9gknd 1337 43 fresh fresh JJ cord-010119-t1x9gknd 1337 44 BC BC NNP cord-010119-t1x9gknd 1337 45 and and CC cord-010119-t1x9gknd 1337 46 PB pb NN cord-010119-t1x9gknd 1337 47 - - HYPH cord-010119-t1x9gknd 1337 48 monocytes monocyte NNS cord-010119-t1x9gknd 1337 49 . . . cord-010119-t1x9gknd 1338 1 Sc2-and Sc2-and NNP cord-010119-t1x9gknd 1338 2 AnWj AnWj NNP cord-010119-t1x9gknd 1338 3 - - HYPH cord-010119-t1x9gknd 1338 4 sensitised sensitise VBN cord-010119-t1x9gknd 1338 5 RBCs rbc NNS cord-010119-t1x9gknd 1338 6 resulted result VBD cord-010119-t1x9gknd 1338 7 in in IN cord-010119-t1x9gknd 1338 8 a a DT cord-010119-t1x9gknd 1338 9 PI pi NN cord-010119-t1x9gknd 1338 10 of of IN cord-010119-t1x9gknd 1338 11 9.2 9.2 CD cord-010119-t1x9gknd 1338 12 6 6 CD cord-010119-t1x9gknd 1338 13 2 2 CD cord-010119-t1x9gknd 1338 14 % % NN cord-010119-t1x9gknd 1338 15 and and CC cord-010119-t1x9gknd 1338 16 60.2 60.2 CD cord-010119-t1x9gknd 1338 17 6 6 CD cord-010119-t1x9gknd 1338 18 6.4 6.4 CD cord-010119-t1x9gknd 1338 19 % % NN cord-010119-t1x9gknd 1338 20 respectively respectively RB cord-010119-t1x9gknd 1338 21 vs vs IN cord-010119-t1x9gknd 1338 22 anti anti JJ cord-010119-t1x9gknd 1338 23 - - JJ cord-010119-t1x9gknd 1338 24 D d JJ cord-010119-t1x9gknd 1338 25 sensitized sensitize VBN cord-010119-t1x9gknd 1338 26 RBCs rbc NNS cord-010119-t1x9gknd 1338 27 ( ( -LRB- cord-010119-t1x9gknd 1338 28 PI pi NN cord-010119-t1x9gknd 1338 29 : : : cord-010119-t1x9gknd 1338 30 72 72 CD cord-010119-t1x9gknd 1338 31 6 6 CD cord-010119-t1x9gknd 1338 32 8.7 8.7 CD cord-010119-t1x9gknd 1338 33 % % NN cord-010119-t1x9gknd 1338 34 ) ) -RRB- cord-010119-t1x9gknd 1338 35 . . . cord-010119-t1x9gknd 1339 1 A a DT cord-010119-t1x9gknd 1339 2 weak weak JJ cord-010119-t1x9gknd 1339 3 ( ( -LRB- cord-010119-t1x9gknd 1339 4 11 11 CD cord-010119-t1x9gknd 1339 5 ) ) -RRB- cord-010119-t1x9gknd 1339 6 reactivity reactivity NN cord-010119-t1x9gknd 1339 7 by by IN cord-010119-t1x9gknd 1339 8 IAT IAT NNP cord-010119-t1x9gknd 1339 9 was be VBD cord-010119-t1x9gknd 1339 10 observed observe VBN cord-010119-t1x9gknd 1339 11 for for IN cord-010119-t1x9gknd 1339 12 anti anti JJ cord-010119-t1x9gknd 1339 13 - - JJ cord-010119-t1x9gknd 1339 14 AnWj anwj JJ cord-010119-t1x9gknd 1339 15 sensitized sensitize VBN cord-010119-t1x9gknd 1339 16 RBCs rbc NNS cord-010119-t1x9gknd 1339 17 while while IN cord-010119-t1x9gknd 1339 18 anti anti JJ cord-010119-t1x9gknd 1339 19 - - JJ cord-010119-t1x9gknd 1339 20 D d JJ cord-010119-t1x9gknd 1339 21 sensitized sensitize VBN cord-010119-t1x9gknd 1339 22 RBCs rbc NNS cord-010119-t1x9gknd 1339 23 resulted result VBD cord-010119-t1x9gknd 1339 24 in in IN cord-010119-t1x9gknd 1339 25 41 41 CD cord-010119-t1x9gknd 1339 26 IAT IAT NNP cord-010119-t1x9gknd 1339 27 reactivity reactivity NN cord-010119-t1x9gknd 1339 28 . . . cord-010119-t1x9gknd 1340 1 These these DT cord-010119-t1x9gknd 1340 2 results result NNS cord-010119-t1x9gknd 1340 3 correlated correlate VBN cord-010119-t1x9gknd 1340 4 with with IN cord-010119-t1x9gknd 1340 5 previously previously RB cord-010119-t1x9gknd 1340 6 reported report VBN cord-010119-t1x9gknd 1340 7 results result NNS cord-010119-t1x9gknd 1340 8 for for IN cord-010119-t1x9gknd 1340 9 clinical clinical JJ cord-010119-t1x9gknd 1340 10 significance significance NN cord-010119-t1x9gknd 1340 11 and and CC cord-010119-t1x9gknd 1340 12 MMA MMA NNP cord-010119-t1x9gknd 1340 13 when when WRB cord-010119-t1x9gknd 1340 14 using use VBG cord-010119-t1x9gknd 1340 15 freshly freshly RB cord-010119-t1x9gknd 1340 16 obtained obtain VBN cord-010119-t1x9gknd 1340 17 autologous autologous JJ cord-010119-t1x9gknd 1340 18 or or CC cord-010119-t1x9gknd 1340 19 healthy healthy JJ cord-010119-t1x9gknd 1340 20 donor donor NN cord-010119-t1x9gknd 1340 21 monocytes monocyte NNS cord-010119-t1x9gknd 1340 22 . . . cord-010119-t1x9gknd 1341 1 Conclusion conclusion NN cord-010119-t1x9gknd 1341 2 : : : cord-010119-t1x9gknd 1342 1 This this DT cord-010119-t1x9gknd 1342 2 study study NN cord-010119-t1x9gknd 1342 3 shows show VBZ cord-010119-t1x9gknd 1342 4 that that IN cord-010119-t1x9gknd 1342 5 cryopreservation cryopreservation NN cord-010119-t1x9gknd 1342 6 preserved preserve VBD cord-010119-t1x9gknd 1342 7 monocyte monocyte NNP cord-010119-t1x9gknd 1342 8 viability viability NN cord-010119-t1x9gknd 1342 9 and and CC cord-010119-t1x9gknd 1342 10 phagocytosis phagocytosis NN cord-010119-t1x9gknd 1342 11 function function VBP cord-010119-t1x9gknd 1342 12 for for IN cord-010119-t1x9gknd 1342 13 MMA MMA NNP cord-010119-t1x9gknd 1342 14 . . . cord-010119-t1x9gknd 1343 1 As as IN cord-010119-t1x9gknd 1343 2 previously previously RB cord-010119-t1x9gknd 1343 3 reported report VBN cord-010119-t1x9gknd 1343 4 with with IN cord-010119-t1x9gknd 1343 5 fresh fresh JJ cord-010119-t1x9gknd 1343 6 monocytes monocyte NNS cord-010119-t1x9gknd 1343 7 MMA MMA NNP cord-010119-t1x9gknd 1343 8 assay assay NN cord-010119-t1x9gknd 1343 9 , , , cord-010119-t1x9gknd 1343 10 the the DT cord-010119-t1x9gknd 1343 11 two two CD cord-010119-t1x9gknd 1343 12 alloantibodies alloantibody NNS cord-010119-t1x9gknd 1343 13 tested test VBN cord-010119-t1x9gknd 1343 14 with with IN cord-010119-t1x9gknd 1343 15 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 1343 16 BC BC NNP cord-010119-t1x9gknd 1343 17 monocytes monocyte NNS cord-010119-t1x9gknd 1343 18 were be VBD cord-010119-t1x9gknd 1343 19 shown show VBN cord-010119-t1x9gknd 1343 20 to to TO cord-010119-t1x9gknd 1343 21 have have VB cord-010119-t1x9gknd 1343 22 a a DT cord-010119-t1x9gknd 1343 23 phagocytic phagocytic JJ cord-010119-t1x9gknd 1343 24 index index NN cord-010119-t1x9gknd 1343 25 of of IN cord-010119-t1x9gknd 1343 26 clinical clinical JJ cord-010119-t1x9gknd 1343 27 significance significance NN cord-010119-t1x9gknd 1343 28 ( ( -LRB- cord-010119-t1x9gknd 1343 29 PI>5 pi>5 CD cord-010119-t1x9gknd 1343 30 % % NN cord-010119-t1x9gknd 1343 31 ) ) -RRB- cord-010119-t1x9gknd 1343 32 . . . cord-010119-t1x9gknd 1344 1 The the DT cord-010119-t1x9gknd 1344 2 use use NN cord-010119-t1x9gknd 1344 3 of of IN cord-010119-t1x9gknd 1344 4 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 1344 5 BC BC NNP cord-010119-t1x9gknd 1344 6 - - HYPH cord-010119-t1x9gknd 1344 7 monocytes monocyte NNS cord-010119-t1x9gknd 1344 8 has have VBZ cord-010119-t1x9gknd 1344 9 the the DT cord-010119-t1x9gknd 1344 10 ability ability NN cord-010119-t1x9gknd 1344 11 We -PRON- PRP cord-010119-t1x9gknd 1344 12 describe describe VBP cord-010119-t1x9gknd 1344 13 antigen antigen NN cord-010119-t1x9gknd 1344 14 typing type VBG cord-010119-t1x9gknd 1344 15 discrepancies discrepancy NNS cord-010119-t1x9gknd 1344 16 in in IN cord-010119-t1x9gknd 1344 17 5 5 CD cord-010119-t1x9gknd 1344 18 patients patient NNS cord-010119-t1x9gknd 1344 19 , , , cord-010119-t1x9gknd 1344 20 involving involve VBG cord-010119-t1x9gknd 1344 21 3 3 CD cord-010119-t1x9gknd 1344 22 antigens antigen NNS cord-010119-t1x9gknd 1344 23 ( ( -LRB- cord-010119-t1x9gknd 1344 24 C C NNP cord-010119-t1x9gknd 1344 25 , , , cord-010119-t1x9gknd 1344 26 Jk Jk NNP cord-010119-t1x9gknd 1344 27 a a NNP cord-010119-t1x9gknd 1344 28 , , , cord-010119-t1x9gknd 1344 29 S S NNP cord-010119-t1x9gknd 1344 30 ) ) -RRB- cord-010119-t1x9gknd 1344 31 , , , cord-010119-t1x9gknd 1344 32 revealed reveal VBD cord-010119-t1x9gknd 1344 33 when when WRB cord-010119-t1x9gknd 1344 34 serologic serologic NNP cord-010119-t1x9gknd 1344 35 results result NNS cord-010119-t1x9gknd 1344 36 differed differ VBD cord-010119-t1x9gknd 1344 37 from from IN cord-010119-t1x9gknd 1344 38 the the DT cord-010119-t1x9gknd 1344 39 phenotype phenotype NN cord-010119-t1x9gknd 1344 40 predicted predict VBN cord-010119-t1x9gknd 1344 41 by by IN cord-010119-t1x9gknd 1344 42 DNA dna NN cord-010119-t1x9gknd 1344 43 testing testing NN cord-010119-t1x9gknd 1344 44 . . . cord-010119-t1x9gknd 1345 1 All all DT cord-010119-t1x9gknd 1345 2 5 5 CD cord-010119-t1x9gknd 1345 3 patients patient NNS cord-010119-t1x9gknd 1345 4 had have VBD cord-010119-t1x9gknd 1345 5 3 3 CD cord-010119-t1x9gknd 1345 6 - - SYM cord-010119-t1x9gknd 1345 7 41 41 CD cord-010119-t1x9gknd 1345 8 positive positive JJ cord-010119-t1x9gknd 1345 9 DAT DAT NNP cord-010119-t1x9gknd 1345 10 with with IN cord-010119-t1x9gknd 1345 11 anti anti JJ cord-010119-t1x9gknd 1345 12 - - JJ cord-010119-t1x9gknd 1345 13 IgG igg JJ cord-010119-t1x9gknd 1345 14 and and CC cord-010119-t1x9gknd 1345 15 warm warm JJ cord-010119-t1x9gknd 1345 16 autoantibodies autoantibody NNS cord-010119-t1x9gknd 1345 17 identified identify VBN cord-010119-t1x9gknd 1345 18 in in IN cord-010119-t1x9gknd 1345 19 the the DT cord-010119-t1x9gknd 1345 20 plasma plasma NN cord-010119-t1x9gknd 1345 21 . . . cord-010119-t1x9gknd 1346 1 Investigation investigation NN cord-010119-t1x9gknd 1346 2 of of IN cord-010119-t1x9gknd 1346 3 the the DT cord-010119-t1x9gknd 1346 4 antigen antigen NN cord-010119-t1x9gknd 1346 5 typing type VBG cord-010119-t1x9gknd 1346 6 discrepancies discrepancy NNS cord-010119-t1x9gknd 1346 7 showed show VBD cord-010119-t1x9gknd 1346 8 both both DT cord-010119-t1x9gknd 1346 9 false false JJ cord-010119-t1x9gknd 1346 10 negative negative JJ cord-010119-t1x9gknd 1346 11 and and CC cord-010119-t1x9gknd 1346 12 false false JJ cord-010119-t1x9gknd 1346 13 positive positive JJ cord-010119-t1x9gknd 1346 14 results result NNS cord-010119-t1x9gknd 1346 15 using use VBG cord-010119-t1x9gknd 1346 16 monoclonal monoclonal JJ cord-010119-t1x9gknd 1346 17 reagents reagent NNS cord-010119-t1x9gknd 1346 18 . . . cord-010119-t1x9gknd 1347 1 Study Study NNP cord-010119-t1x9gknd 1347 2 Design Design NNP cord-010119-t1x9gknd 1347 3 / / SYM cord-010119-t1x9gknd 1347 4 Method method NN cord-010119-t1x9gknd 1347 5 : : : cord-010119-t1x9gknd 1348 1 Standard standard JJ cord-010119-t1x9gknd 1348 2 tube tube NN cord-010119-t1x9gknd 1348 3 hemagglutination hemagglutination NN cord-010119-t1x9gknd 1348 4 methods method NNS cord-010119-t1x9gknd 1348 5 were be VBD cord-010119-t1x9gknd 1348 6 used use VBN cord-010119-t1x9gknd 1348 7 for for IN cord-010119-t1x9gknd 1348 8 antigen antigen NN cord-010119-t1x9gknd 1348 9 typing typing NN cord-010119-t1x9gknd 1348 10 . . . cord-010119-t1x9gknd 1349 1 RBCs rbc NNS cord-010119-t1x9gknd 1349 2 were be VBD cord-010119-t1x9gknd 1349 3 treated treat VBN cord-010119-t1x9gknd 1349 4 with with IN cord-010119-t1x9gknd 1349 5 EDTA EDTA NNP cord-010119-t1x9gknd 1349 6 glycine glycine NN cord-010119-t1x9gknd 1349 7 - - HYPH cord-010119-t1x9gknd 1349 8 acid acid NN cord-010119-t1x9gknd 1349 9 ( ( -LRB- cord-010119-t1x9gknd 1349 10 EGA EGA NNP cord-010119-t1x9gknd 1349 11 ) ) -RRB- cord-010119-t1x9gknd 1349 12 using use VBG cord-010119-t1x9gknd 1349 13 Gamma Gamma NNP cord-010119-t1x9gknd 1349 14 EGA EGA NNP cord-010119-t1x9gknd 1349 15 Kit kit NN cord-010119-t1x9gknd 1349 16 . . . cord-010119-t1x9gknd 1350 1 Genomic genomic JJ cord-010119-t1x9gknd 1350 2 DNA dna NN cord-010119-t1x9gknd 1350 3 was be VBD cord-010119-t1x9gknd 1350 4 isolated isolate VBN cord-010119-t1x9gknd 1350 5 from from IN cord-010119-t1x9gknd 1350 6 WBCs wbc NNS cord-010119-t1x9gknd 1350 7 and and CC cord-010119-t1x9gknd 1350 8 HEA HEA NNP cord-010119-t1x9gknd 1350 9 PreciseType PreciseType NNP cord-010119-t1x9gknd 1350 10 performed perform VBD cord-010119-t1x9gknd 1350 11 . . . cord-010119-t1x9gknd 1351 1 Results result NNS cord-010119-t1x9gknd 1351 2 / / SYM cord-010119-t1x9gknd 1351 3 Finding finding NN cord-010119-t1x9gknd 1351 4 : : : cord-010119-t1x9gknd 1352 1 The the DT cord-010119-t1x9gknd 1352 2 RBCs rbc NNS cord-010119-t1x9gknd 1352 3 of of IN cord-010119-t1x9gknd 1352 4 patients patient NNS cord-010119-t1x9gknd 1352 5 1 1 CD cord-010119-t1x9gknd 1352 6 and and CC cord-010119-t1x9gknd 1352 7 2 2 CD cord-010119-t1x9gknd 1352 8 typed type VBN cord-010119-t1x9gknd 1352 9 C C NNP cord-010119-t1x9gknd 1352 10 - - HYPH cord-010119-t1x9gknd 1352 11 on on RP cord-010119-t1x9gknd 1352 12 initial initial JJ cord-010119-t1x9gknd 1352 13 testing testing NN cord-010119-t1x9gknd 1352 14 with with IN cord-010119-t1x9gknd 1352 15 Immucor Immucor NNP cord-010119-t1x9gknd 1352 16 Gamma Gamma NNP cord-010119-t1x9gknd 1352 17 - - HYPH cord-010119-t1x9gknd 1352 18 clone clone NN cord-010119-t1x9gknd 1352 19 anti anti JJ cord-010119-t1x9gknd 1352 20 - - JJ cord-010119-t1x9gknd 1352 21 C C NNP cord-010119-t1x9gknd 1352 22 , , , cord-010119-t1x9gknd 1352 23 but but CC cord-010119-t1x9gknd 1352 24 were be VBD cord-010119-t1x9gknd 1352 25 predicted predict VBN cord-010119-t1x9gknd 1352 26 C1 C1 NNP cord-010119-t1x9gknd 1352 27 by by IN cord-010119-t1x9gknd 1352 28 HEA HEA NNP cord-010119-t1x9gknd 1352 29 Precise Precise NNP cord-010119-t1x9gknd 1352 30 - - HYPH cord-010119-t1x9gknd 1352 31 Type type NN cord-010119-t1x9gknd 1352 32 . . . cord-010119-t1x9gknd 1353 1 EGA EGA NNP cord-010119-t1x9gknd 1353 2 - - HYPH cord-010119-t1x9gknd 1353 3 treated treat VBN cord-010119-t1x9gknd 1353 4 RBCs rbc NNS cord-010119-t1x9gknd 1353 5 gave give VBD cord-010119-t1x9gknd 1353 6 31 31 CD cord-010119-t1x9gknd 1353 7 reactions reaction NNS cord-010119-t1x9gknd 1353 8 with with IN cord-010119-t1x9gknd 1353 9 the the DT cord-010119-t1x9gknd 1353 10 same same JJ cord-010119-t1x9gknd 1353 11 anti anti JJ cord-010119-t1x9gknd 1353 12 - - JJ cord-010119-t1x9gknd 1353 13 C c JJ cord-010119-t1x9gknd 1353 14 reagent reagent NN cord-010119-t1x9gknd 1353 15 . . . cord-010119-t1x9gknd 1354 1 Patient patient NN cord-010119-t1x9gknd 1354 2 1 1 CD cord-010119-t1x9gknd 1354 3 RBCs rbc NNS cord-010119-t1x9gknd 1354 4 gave give VBD cord-010119-t1x9gknd 1354 5 variable variable JJ cord-010119-t1x9gknd 1354 6 reactivity reactivity NN cord-010119-t1x9gknd 1354 7 ( ( -LRB- cord-010119-t1x9gknd 1354 8 vw-11 vw-11 NN cord-010119-t1x9gknd 1354 9 ) ) -RRB- cord-010119-t1x9gknd 1354 10 with with IN cord-010119-t1x9gknd 1354 11 Bio Bio NNP cord-010119-t1x9gknd 1354 12 - - HYPH cord-010119-t1x9gknd 1354 13 Rad Rad NNP cord-010119-t1x9gknd 1354 14 Seraclone Seraclone NNP cord-010119-t1x9gknd 1354 15 and and CC cord-010119-t1x9gknd 1354 16 Ortho Ortho NNP cord-010119-t1x9gknd 1354 17 BioClone BioClone NNP cord-010119-t1x9gknd 1354 18 anti anti JJ cord-010119-t1x9gknd 1354 19 - - NNP cord-010119-t1x9gknd 1354 20 C. C. NNP cord-010119-t1x9gknd 1354 21 Patient Patient NNP cord-010119-t1x9gknd 1354 22 2 2 CD cord-010119-t1x9gknd 1354 23 RBCs rbc NNS cord-010119-t1x9gknd 1354 24 gave give VBD cord-010119-t1x9gknd 1354 25 11 11 CD cord-010119-t1x9gknd 1354 26 reactivity reactivity NN cord-010119-t1x9gknd 1354 27 with with IN cord-010119-t1x9gknd 1354 28 all all DT cord-010119-t1x9gknd 1354 29 3 3 CD cord-010119-t1x9gknd 1354 30 anti anti JJ cord-010119-t1x9gknd 1354 31 - - JJ cord-010119-t1x9gknd 1354 32 C c JJ cord-010119-t1x9gknd 1354 33 reagents reagent NNS cord-010119-t1x9gknd 1354 34 when when WRB cord-010119-t1x9gknd 1354 35 incubated incubate VBN cord-010119-t1x9gknd 1354 36 for for IN cord-010119-t1x9gknd 1354 37 the the DT cord-010119-t1x9gknd 1354 38 maximum maximum JJ cord-010119-t1x9gknd 1354 39 incubation incubation NN cord-010119-t1x9gknd 1354 40 time time NN cord-010119-t1x9gknd 1354 41 allowed allow VBN cord-010119-t1x9gknd 1354 42 . . . cord-010119-t1x9gknd 1355 1 Patient patient NN cord-010119-t1x9gknd 1355 2 3 3 CD cord-010119-t1x9gknd 1355 3 RBCs rbc NNS cord-010119-t1x9gknd 1355 4 were be VBD cord-010119-t1x9gknd 1355 5 Jk(a1 Jk(a1 -LRB- cord-010119-t1x9gknd 1355 6 ) ) -RRB- cord-010119-t1x9gknd 1355 7 with with IN cord-010119-t1x9gknd 1355 8 Immucor Immucor NNP cord-010119-t1x9gknd 1355 9 Gammaclone Gammaclone NNP cord-010119-t1x9gknd 1355 10 anti anti NNP cord-010119-t1x9gknd 1355 11 - - NNP cord-010119-t1x9gknd 1355 12 Jk Jk NNP cord-010119-t1x9gknd 1355 13 a a DT cord-010119-t1x9gknd 1355 14 , , , cord-010119-t1x9gknd 1355 15 which which WDT cord-010119-t1x9gknd 1355 16 the the DT cord-010119-t1x9gknd 1355 17 manufacturer manufacturer NN cord-010119-t1x9gknd 1355 18 states state VBZ cord-010119-t1x9gknd 1355 19 is be VBZ cord-010119-t1x9gknd 1355 20 suitable suitable JJ cord-010119-t1x9gknd 1355 21 for for IN cord-010119-t1x9gknd 1355 22 testing test VBG cord-010119-t1x9gknd 1355 23 DAT1RBCs dat1rbcs NN cord-010119-t1x9gknd 1355 24 , , , cord-010119-t1x9gknd 1355 25 but but CC cord-010119-t1x9gknd 1355 26 predicted predict VBD cord-010119-t1x9gknd 1355 27 Jk(a- jk(a- CD cord-010119-t1x9gknd 1355 28 ) ) -RRB- cord-010119-t1x9gknd 1355 29 by by IN cord-010119-t1x9gknd 1355 30 HEA HEA NNP cord-010119-t1x9gknd 1355 31 . . . cord-010119-t1x9gknd 1356 1 EGA EGA NNP cord-010119-t1x9gknd 1356 2 - - HYPH cord-010119-t1x9gknd 1356 3 treated treat VBN cord-010119-t1x9gknd 1356 4 RBCs rbc NNS cord-010119-t1x9gknd 1356 5 tested test VBD cord-010119-t1x9gknd 1356 6 Jk(a- jk(a- CD cord-010119-t1x9gknd 1356 7 ) ) -RRB- cord-010119-t1x9gknd 1356 8 with with IN cord-010119-t1x9gknd 1356 9 the the DT cord-010119-t1x9gknd 1356 10 same same JJ cord-010119-t1x9gknd 1356 11 reagent reagent NN cord-010119-t1x9gknd 1356 12 . . . cord-010119-t1x9gknd 1357 1 RBCs rbc NNS cord-010119-t1x9gknd 1357 2 from from IN cord-010119-t1x9gknd 1357 3 patients patient NNS cord-010119-t1x9gknd 1357 4 4 4 CD cord-010119-t1x9gknd 1357 5 and and CC cord-010119-t1x9gknd 1357 6 5 5 CD cord-010119-t1x9gknd 1357 7 tested test VBN cord-010119-t1x9gknd 1357 8 S1 S1 NNP cord-010119-t1x9gknd 1357 9 with with IN cord-010119-t1x9gknd 1357 10 Bio Bio NNP cord-010119-t1x9gknd 1357 11 - - HYPH cord-010119-t1x9gknd 1357 12 Rad Rad NNP cord-010119-t1x9gknd 1357 13 Seraclone Seraclone NNP cord-010119-t1x9gknd 1357 14 anti anti NNP cord-010119-t1x9gknd 1357 15 - - NNP cord-010119-t1x9gknd 1357 16 S s JJ cord-010119-t1x9gknd 1357 17 ( ( -LRB- cord-010119-t1x9gknd 1357 18 3 3 CD cord-010119-t1x9gknd 1357 19 - - SYM cord-010119-t1x9gknd 1357 20 41 41 CD cord-010119-t1x9gknd 1357 21 ) ) -RRB- cord-010119-t1x9gknd 1357 22 , , , cord-010119-t1x9gknd 1357 23 but but CC cord-010119-t1x9gknd 1357 24 predicted predict VBD cord-010119-t1x9gknd 1357 25 S S NNP cord-010119-t1x9gknd 1357 26 - - HYPH cord-010119-t1x9gknd 1357 27 by by IN cord-010119-t1x9gknd 1357 28 HEA HEA NNP cord-010119-t1x9gknd 1357 29 . . . cord-010119-t1x9gknd 1358 1 Further further RB cord-010119-t1x9gknd 1358 2 testing testing NN cord-010119-t1x9gknd 1358 3 with with IN cord-010119-t1x9gknd 1358 4 Immucor Immucor NNP cord-010119-t1x9gknd 1358 5 Gammaclone Gammaclone NNP cord-010119-t1x9gknd 1358 6 anti anti NNP cord-010119-t1x9gknd 1358 7 - - NNP cord-010119-t1x9gknd 1358 8 S S NNP cord-010119-t1x9gknd 1358 9 showed show VBD cord-010119-t1x9gknd 1358 10 RBCs rbc NNS cord-010119-t1x9gknd 1358 11 from from IN cord-010119-t1x9gknd 1358 12 both both DT cord-010119-t1x9gknd 1358 13 patients patient NNS cord-010119-t1x9gknd 1358 14 were be VBD cord-010119-t1x9gknd 1358 15 S- s- XX cord-010119-t1x9gknd 1358 16 . . . cord-010119-t1x9gknd 1359 1 EGA EGA NNP cord-010119-t1x9gknd 1359 2 - - HYPH cord-010119-t1x9gknd 1359 3 treated treat VBN cord-010119-t1x9gknd 1359 4 RBCs rbc NNS cord-010119-t1x9gknd 1359 5 from from IN cord-010119-t1x9gknd 1359 6 both both DT cord-010119-t1x9gknd 1359 7 were be VBD cord-010119-t1x9gknd 1359 8 non non JJ cord-010119-t1x9gknd 1359 9 - - JJ cord-010119-t1x9gknd 1359 10 reactive reactive JJ cord-010119-t1x9gknd 1359 11 with with IN cord-010119-t1x9gknd 1359 12 both both DT cord-010119-t1x9gknd 1359 13 anti anti JJ cord-010119-t1x9gknd 1359 14 - - JJ cord-010119-t1x9gknd 1359 15 S s JJ cord-010119-t1x9gknd 1359 16 reagents reagent NNS cord-010119-t1x9gknd 1359 17 . . . cord-010119-t1x9gknd 1360 1 Conclusion conclusion NN cord-010119-t1x9gknd 1360 2 : : : cord-010119-t1x9gknd 1361 1 Commercial commercial JJ cord-010119-t1x9gknd 1361 2 monoclonal monoclonal JJ cord-010119-t1x9gknd 1361 3 reagents reagent NNS cord-010119-t1x9gknd 1361 4 are be VBP cord-010119-t1x9gknd 1361 5 valuable valuable JJ cord-010119-t1x9gknd 1361 6 resources resource NNS cord-010119-t1x9gknd 1361 7 , , , cord-010119-t1x9gknd 1361 8 especially especially RB cord-010119-t1x9gknd 1361 9 when when WRB cord-010119-t1x9gknd 1361 10 phenotyping phenotype VBG cord-010119-t1x9gknd 1361 11 DAT1 DAT1 NNP cord-010119-t1x9gknd 1361 12 RBCs rbc NNS cord-010119-t1x9gknd 1361 13 but but CC cord-010119-t1x9gknd 1361 14 not not RB cord-010119-t1x9gknd 1361 15 all all DT cord-010119-t1x9gknd 1361 16 manufacturers manufacturer NNS cord-010119-t1x9gknd 1361 17 include include VBP cord-010119-t1x9gknd 1361 18 reagent reagent NN cord-010119-t1x9gknd 1361 19 limitations limitation NNS cord-010119-t1x9gknd 1361 20 regarding regard VBG cord-010119-t1x9gknd 1361 21 testing testing NN cord-010119-t1x9gknd 1361 22 of of IN cord-010119-t1x9gknd 1361 23 DAT1 DAT1 NNP cord-010119-t1x9gknd 1361 24 RBCs rbc NNS cord-010119-t1x9gknd 1361 25 . . . cord-010119-t1x9gknd 1362 1 We -PRON- PRP cord-010119-t1x9gknd 1362 2 describe describe VBP cord-010119-t1x9gknd 1362 3 2 2 CD cord-010119-t1x9gknd 1362 4 cases case NNS cord-010119-t1x9gknd 1362 5 of of IN cord-010119-t1x9gknd 1362 6 false false JJ cord-010119-t1x9gknd 1362 7 negative negative JJ cord-010119-t1x9gknd 1362 8 tests test NNS cord-010119-t1x9gknd 1362 9 with with IN cord-010119-t1x9gknd 1362 10 monoclonal monoclonal JJ cord-010119-t1x9gknd 1362 11 anti anti JJ cord-010119-t1x9gknd 1362 12 - - JJ cord-010119-t1x9gknd 1362 13 C C NNP cord-010119-t1x9gknd 1362 14 due due IN cord-010119-t1x9gknd 1362 15 to to IN cord-010119-t1x9gknd 1362 16 antigen antigen NN cord-010119-t1x9gknd 1362 17 blocking block VBG cord-010119-t1x9gknd 1362 18 by by IN cord-010119-t1x9gknd 1362 19 IgG IgG NNP cord-010119-t1x9gknd 1362 20 , , , cord-010119-t1x9gknd 1362 21 and and CC cord-010119-t1x9gknd 1362 22 3 3 CD cord-010119-t1x9gknd 1362 23 cases case NNS cord-010119-t1x9gknd 1362 24 with with IN cord-010119-t1x9gknd 1362 25 false false JJ cord-010119-t1x9gknd 1362 26 positive positive JJ cord-010119-t1x9gknd 1362 27 tests test NNS cord-010119-t1x9gknd 1362 28 with with IN cord-010119-t1x9gknd 1362 29 anti anti JJ cord-010119-t1x9gknd 1362 30 - - JJ cord-010119-t1x9gknd 1362 31 S s JJ cord-010119-t1x9gknd 1362 32 ( ( -LRB- cord-010119-t1x9gknd 1362 33 n52 n52 NNP cord-010119-t1x9gknd 1362 34 ) ) -RRB- cord-010119-t1x9gknd 1362 35 and and CC cord-010119-t1x9gknd 1362 36 anti anti JJ cord-010119-t1x9gknd 1362 37 - - NN cord-010119-t1x9gknd 1362 38 Jk Jk NNP cord-010119-t1x9gknd 1363 1 a a LS cord-010119-t1x9gknd 1363 2 ( ( -LRB- cord-010119-t1x9gknd 1363 3 n51 n51 NN cord-010119-t1x9gknd 1363 4 ) ) -RRB- cord-010119-t1x9gknd 1363 5 typing typing NN cord-010119-t1x9gknd 1363 6 . . . cord-010119-t1x9gknd 1364 1 False false JJ cord-010119-t1x9gknd 1364 2 positive positive JJ cord-010119-t1x9gknd 1364 3 tests test NNS cord-010119-t1x9gknd 1364 4 would would MD cord-010119-t1x9gknd 1364 5 potentially potentially RB cord-010119-t1x9gknd 1364 6 be be VB cord-010119-t1x9gknd 1364 7 anticipated anticipate VBN cord-010119-t1x9gknd 1364 8 , , , cord-010119-t1x9gknd 1364 9 but but CC cord-010119-t1x9gknd 1364 10 false false JJ cord-010119-t1x9gknd 1364 11 negative negative JJ cord-010119-t1x9gknd 1364 12 results result NNS cord-010119-t1x9gknd 1364 13 due due JJ cord-010119-t1x9gknd 1364 14 to to IN cord-010119-t1x9gknd 1364 15 antigen antigen NN cord-010119-t1x9gknd 1364 16 blocking block VBG cord-010119-t1x9gknd 1364 17 are be VBP cord-010119-t1x9gknd 1364 18 unexpected unexpected JJ cord-010119-t1x9gknd 1364 19 . . . cord-010119-t1x9gknd 1365 1 Extended extend VBN cord-010119-t1x9gknd 1365 2 incubation incubation NN cord-010119-t1x9gknd 1365 3 as as IN cord-010119-t1x9gknd 1365 4 indicated indicate VBN cord-010119-t1x9gknd 1365 5 in in IN cord-010119-t1x9gknd 1365 6 the the DT cord-010119-t1x9gknd 1365 7 reagent reagent NN cord-010119-t1x9gknd 1365 8 insert insert NN cord-010119-t1x9gknd 1365 9 may may MD cord-010119-t1x9gknd 1365 10 reveal reveal VB cord-010119-t1x9gknd 1365 11 weak weak JJ cord-010119-t1x9gknd 1365 12 reactivity reactivity NN cord-010119-t1x9gknd 1365 13 when when WRB cord-010119-t1x9gknd 1365 14 antigen antigen NN cord-010119-t1x9gknd 1365 15 blocking blocking NN cord-010119-t1x9gknd 1365 16 is be VBZ cord-010119-t1x9gknd 1365 17 involved involve VBN cord-010119-t1x9gknd 1365 18 . . . cord-010119-t1x9gknd 1366 1 Results result NNS cord-010119-t1x9gknd 1366 2 concordant concordant JJ cord-010119-t1x9gknd 1366 3 with with IN cord-010119-t1x9gknd 1366 4 DNA dna NN cord-010119-t1x9gknd 1366 5 testing testing NN cord-010119-t1x9gknd 1366 6 were be VBD cord-010119-t1x9gknd 1366 7 obtained obtain VBN cord-010119-t1x9gknd 1366 8 with with IN cord-010119-t1x9gknd 1366 9 EGA EGA NNP cord-010119-t1x9gknd 1366 10 - - HYPH cord-010119-t1x9gknd 1366 11 treated treat VBN cord-010119-t1x9gknd 1366 12 RBCs rbc NNS cord-010119-t1x9gknd 1366 13 , , , cord-010119-t1x9gknd 1366 14 but but CC cord-010119-t1x9gknd 1366 15 it -PRON- PRP cord-010119-t1x9gknd 1366 16 is be VBZ cord-010119-t1x9gknd 1366 17 generally generally RB cord-010119-t1x9gknd 1366 18 accepted accept VBN cord-010119-t1x9gknd 1366 19 that that IN cord-010119-t1x9gknd 1366 20 this this DT cord-010119-t1x9gknd 1366 21 is be VBZ cord-010119-t1x9gknd 1366 22 not not RB cord-010119-t1x9gknd 1366 23 necessary necessary JJ cord-010119-t1x9gknd 1366 24 when when WRB cord-010119-t1x9gknd 1366 25 using use VBG cord-010119-t1x9gknd 1366 26 a a DT cord-010119-t1x9gknd 1366 27 direct direct RB cord-010119-t1x9gknd 1366 28 - - HYPH cord-010119-t1x9gknd 1366 29 agglutinating agglutinate VBG cord-010119-t1x9gknd 1366 30 monoclonal monoclonal JJ cord-010119-t1x9gknd 1366 31 reagent reagent NN cord-010119-t1x9gknd 1366 32 . . . cord-010119-t1x9gknd 1367 1 These these DT cord-010119-t1x9gknd 1367 2 cases case NNS cord-010119-t1x9gknd 1367 3 caution caution VBP cord-010119-t1x9gknd 1367 4 the the DT cord-010119-t1x9gknd 1367 5 potential potential NN cord-010119-t1x9gknd 1367 6 for for IN cord-010119-t1x9gknd 1367 7 both both DT cord-010119-t1x9gknd 1367 8 false false JJ cord-010119-t1x9gknd 1367 9 negative negative JJ cord-010119-t1x9gknd 1367 10 and and CC cord-010119-t1x9gknd 1367 11 false false JJ cord-010119-t1x9gknd 1367 12 positive positive JJ cord-010119-t1x9gknd 1367 13 results result NNS cord-010119-t1x9gknd 1367 14 for for IN cord-010119-t1x9gknd 1367 15 samples sample NNS cord-010119-t1x9gknd 1367 16 with with IN cord-010119-t1x9gknd 1367 17 3 3 CD cord-010119-t1x9gknd 1367 18 - - SYM cord-010119-t1x9gknd 1367 19 41 41 CD cord-010119-t1x9gknd 1367 20 positive positive JJ cord-010119-t1x9gknd 1367 21 DAT dat NN cord-010119-t1x9gknd 1367 22 and and CC cord-010119-t1x9gknd 1367 23 supports support VBZ cord-010119-t1x9gknd 1367 24 testing testing NN cord-010119-t1x9gknd 1367 25 to to TO cord-010119-t1x9gknd 1367 26 dissociate dissociate VB cord-010119-t1x9gknd 1367 27 IgG igg NN cord-010119-t1x9gknd 1367 28 from from IN cord-010119-t1x9gknd 1367 29 RBCs rbc NNS cord-010119-t1x9gknd 1367 30 strongly strongly RB cord-010119-t1x9gknd 1367 31 DAT1 DAT1 NNP cord-010119-t1x9gknd 1367 32 before before IN cord-010119-t1x9gknd 1367 33 antigen antigen NN cord-010119-t1x9gknd 1367 34 typing typing NN cord-010119-t1x9gknd 1367 35 . . . cord-010119-t1x9gknd 1368 1 In in IN cord-010119-t1x9gknd 1368 2 addition addition NN cord-010119-t1x9gknd 1368 3 , , , cord-010119-t1x9gknd 1368 4 this this DT cord-010119-t1x9gknd 1368 5 report report NN cord-010119-t1x9gknd 1368 6 highlights highlight VBZ cord-010119-t1x9gknd 1368 7 the the DT cord-010119-t1x9gknd 1368 8 benefits benefit NNS cord-010119-t1x9gknd 1368 9 of of IN cord-010119-t1x9gknd 1368 10 DNA dna NN cord-010119-t1x9gknd 1368 11 testing testing NN cord-010119-t1x9gknd 1368 12 as as IN cord-010119-t1x9gknd 1368 13 part part NN cord-010119-t1x9gknd 1368 14 of of IN cord-010119-t1x9gknd 1368 15 the the DT cord-010119-t1x9gknd 1368 16 routine routine JJ cord-010119-t1x9gknd 1368 17 reference reference NN cord-010119-t1x9gknd 1368 18 laboratory laboratory NN cord-010119-t1x9gknd 1368 19 workup workup NN cord-010119-t1x9gknd 1368 20 . . . cord-010119-t1x9gknd 1369 1 Background Background NNP cord-010119-t1x9gknd 1369 2 / / SYM cord-010119-t1x9gknd 1369 3 Case Case NNP cord-010119-t1x9gknd 1369 4 Studies Studies NNPS cord-010119-t1x9gknd 1369 5 : : : cord-010119-t1x9gknd 1370 1 Sensitization sensitization NN cord-010119-t1x9gknd 1370 2 to to IN cord-010119-t1x9gknd 1370 3 antigens antigen NNS cord-010119-t1x9gknd 1370 4 expressed express VBN cord-010119-t1x9gknd 1370 5 on on IN cord-010119-t1x9gknd 1370 6 transfused transfused JJ cord-010119-t1x9gknd 1370 7 cells cell NNS cord-010119-t1x9gknd 1370 8 , , , cord-010119-t1x9gknd 1370 9 by by IN cord-010119-t1x9gknd 1370 10 triggering trigger VBG cord-010119-t1x9gknd 1370 11 premature premature JJ cord-010119-t1x9gknd 1370 12 antibody antibody NN cord-010119-t1x9gknd 1370 13 - - HYPH cord-010119-t1x9gknd 1370 14 mediated mediate VBN cord-010119-t1x9gknd 1370 15 clearance clearance NN cord-010119-t1x9gknd 1370 16 , , , cord-010119-t1x9gknd 1370 17 diminishes diminish VBZ cord-010119-t1x9gknd 1370 18 the the DT cord-010119-t1x9gknd 1370 19 therapeutic therapeutic JJ cord-010119-t1x9gknd 1370 20 effectiveness effectiveness NN cord-010119-t1x9gknd 1370 21 of of IN cord-010119-t1x9gknd 1370 22 transfusion transfusion NN cord-010119-t1x9gknd 1370 23 and and CC cord-010119-t1x9gknd 1370 24 may may MD cord-010119-t1x9gknd 1370 25 also also RB cord-010119-t1x9gknd 1370 26 lead lead VB cord-010119-t1x9gknd 1370 27 to to IN cord-010119-t1x9gknd 1370 28 serious serious JJ cord-010119-t1x9gknd 1370 29 delayed delayed JJ cord-010119-t1x9gknd 1370 30 hemolytic hemolytic JJ cord-010119-t1x9gknd 1370 31 transfusion transfusion NN cord-010119-t1x9gknd 1370 32 reactions reaction NNS cord-010119-t1x9gknd 1370 33 . . . cord-010119-t1x9gknd 1371 1 Accepted accept VBN cord-010119-t1x9gknd 1371 2 US US NNP cord-010119-t1x9gknd 1371 3 clinical clinical JJ cord-010119-t1x9gknd 1371 4 practice practice NN cord-010119-t1x9gknd 1371 5 , , , cord-010119-t1x9gknd 1371 6 while while IN cord-010119-t1x9gknd 1371 7 providing provide VBG cord-010119-t1x9gknd 1371 8 that that IN cord-010119-t1x9gknd 1371 9 sensitized sensitize VBN cord-010119-t1x9gknd 1371 10 patients patient NNS cord-010119-t1x9gknd 1371 11 receive receive VBP cord-010119-t1x9gknd 1371 12 only only RB cord-010119-t1x9gknd 1371 13 cells cell NNS cord-010119-t1x9gknd 1371 14 lacking lack VBG cord-010119-t1x9gknd 1371 15 " " `` cord-010119-t1x9gknd 1371 16 offending offend VBG cord-010119-t1x9gknd 1371 17 " " '' cord-010119-t1x9gknd 1371 18 antigens antigen NNS cord-010119-t1x9gknd 1371 19 , , , cord-010119-t1x9gknd 1371 20 nevertheless nevertheless RB cord-010119-t1x9gknd 1371 21 ensures ensure VBZ cord-010119-t1x9gknd 1371 22 continued continue VBN cord-010119-t1x9gknd 1371 23 alloexposure alloexposure NN cord-010119-t1x9gknd 1371 24 , , , cord-010119-t1x9gknd 1371 25 and and CC cord-010119-t1x9gknd 1371 26 thus thus RB cord-010119-t1x9gknd 1371 27 possible possible JJ cord-010119-t1x9gknd 1371 28 sensitization sensitization NN cord-010119-t1x9gknd 1371 29 , , , cord-010119-t1x9gknd 1371 30 to to IN cord-010119-t1x9gknd 1371 31 additional additional JJ cord-010119-t1x9gknd 1371 32 antigens antigen NNS cord-010119-t1x9gknd 1371 33 , , , cord-010119-t1x9gknd 1371 34 thereby thereby RB cord-010119-t1x9gknd 1371 35 complicating complicate VBG cord-010119-t1x9gknd 1371 36 patient patient JJ cord-010119-t1x9gknd 1371 37 management management NN cord-010119-t1x9gknd 1371 38 . . . cord-010119-t1x9gknd 1372 1 To to TO cord-010119-t1x9gknd 1372 2 mitigate mitigate VB cord-010119-t1x9gknd 1372 3 sensitization sensitization NN cord-010119-t1x9gknd 1372 4 risk risk NN cord-010119-t1x9gknd 1372 5 , , , cord-010119-t1x9gknd 1372 6 especially especially RB cord-010119-t1x9gknd 1372 7 in in IN cord-010119-t1x9gknd 1372 8 an an DT cord-010119-t1x9gknd 1372 9 era era NN cord-010119-t1x9gknd 1372 10 of of IN cord-010119-t1x9gknd 1372 11 increasingly increasingly RB cord-010119-t1x9gknd 1372 12 cost cost NN cord-010119-t1x9gknd 1372 13 - - HYPH cord-010119-t1x9gknd 1372 14 conscious conscious JJ cord-010119-t1x9gknd 1372 15 procurement procurement NN cord-010119-t1x9gknd 1372 16 , , , cord-010119-t1x9gknd 1372 17 a a DT cord-010119-t1x9gknd 1372 18 quantitative quantitative JJ cord-010119-t1x9gknd 1372 19 assessment assessment NN cord-010119-t1x9gknd 1372 20 of of IN cord-010119-t1x9gknd 1372 21 the the DT cord-010119-t1x9gknd 1372 22 immunogenicity immunogenicity NN cord-010119-t1x9gknd 1372 23 of of IN cord-010119-t1x9gknd 1372 24 specific specific JJ cord-010119-t1x9gknd 1372 25 antigens antigen NNS cord-010119-t1x9gknd 1372 26 will will MD cord-010119-t1x9gknd 1372 27 be be VB cord-010119-t1x9gknd 1372 28 desirable desirable JJ cord-010119-t1x9gknd 1372 29 . . . cord-010119-t1x9gknd 1373 1 Giblett Giblett NNP cord-010119-t1x9gknd 1373 2 , , , cord-010119-t1x9gknd 1373 3 long long RB cord-010119-t1x9gknd 1373 4 ago ago RB cord-010119-t1x9gknd 1373 5 , , , cord-010119-t1x9gknd 1373 6 introduced introduce VBD cord-010119-t1x9gknd 1373 7 a a DT cord-010119-t1x9gknd 1373 8 relative relative JJ cord-010119-t1x9gknd 1373 9 scale scale NN cord-010119-t1x9gknd 1373 10 relating relate VBG cord-010119-t1x9gknd 1373 11 the the DT cord-010119-t1x9gknd 1373 12 RBC RBC NNP cord-010119-t1x9gknd 1373 13 antigen antigen NN cord-010119-t1x9gknd 1373 14 immunogenicities immunogenicity NNS cord-010119-t1x9gknd 1373 15 to to IN cord-010119-t1x9gknd 1373 16 ( ( -LRB- cord-010119-t1x9gknd 1373 17 an an DT cord-010119-t1x9gknd 1373 18 assumed assumed JJ cord-010119-t1x9gknd 1373 19 ) ) -RRB- cord-010119-t1x9gknd 1373 20 immunogenicity immunogenicity NN cord-010119-t1x9gknd 1373 21 of of IN cord-010119-t1x9gknd 1373 22 " " `` cord-010119-t1x9gknd 1373 23 K K NNP cord-010119-t1x9gknd 1373 24 " " '' cord-010119-t1x9gknd 1373 25 ( ( -LRB- cord-010119-t1x9gknd 1373 26 http://bit.ly/2opqFew http://bit.ly/2opqFew NNP cord-010119-t1x9gknd 1373 27 ) ) -RRB- cord-010119-t1x9gknd 1373 28 . . . cord-010119-t1x9gknd 1374 1 Here here RB cord-010119-t1x9gknd 1374 2 , , , cord-010119-t1x9gknd 1374 3 we -PRON- PRP cord-010119-t1x9gknd 1374 4 show show VBP cord-010119-t1x9gknd 1374 5 that that IN cord-010119-t1x9gknd 1374 6 an an DT cord-010119-t1x9gknd 1374 7 absolute absolute JJ cord-010119-t1x9gknd 1374 8 estimate estimate NN cord-010119-t1x9gknd 1374 9 of of IN cord-010119-t1x9gknd 1374 10 immunogenicities immunogenicity NNS cord-010119-t1x9gknd 1374 11 may may MD cord-010119-t1x9gknd 1374 12 be be VB cord-010119-t1x9gknd 1374 13 extracted extract VBN cord-010119-t1x9gknd 1374 14 directly directly RB cord-010119-t1x9gknd 1374 15 from from IN cord-010119-t1x9gknd 1374 16 observed observed JJ cord-010119-t1x9gknd 1374 17 antibody antibody NN cord-010119-t1x9gknd 1374 18 counts count NNS cord-010119-t1x9gknd 1374 19 provided provide VBN cord-010119-t1x9gknd 1374 20 these these DT cord-010119-t1x9gknd 1374 21 are be VBP cord-010119-t1x9gknd 1374 22 properly properly RB cord-010119-t1x9gknd 1374 23 normalized normalize VBN cord-010119-t1x9gknd 1374 24 to to IN cord-010119-t1x9gknd 1374 25 the the DT cord-010119-t1x9gknd 1374 26 fraction fraction NN cord-010119-t1x9gknd 1374 27 of of IN cord-010119-t1x9gknd 1374 28 recipients recipient NNS cord-010119-t1x9gknd 1374 29 at at IN cord-010119-t1x9gknd 1374 30 risk risk NN cord-010119-t1x9gknd 1374 31 ( ( -LRB- cord-010119-t1x9gknd 1374 32 namely namely RB cord-010119-t1x9gknd 1374 33 those those DT cord-010119-t1x9gknd 1374 34 lacking lack VBG cord-010119-t1x9gknd 1374 35 a a DT cord-010119-t1x9gknd 1374 36 specific specific JJ cord-010119-t1x9gknd 1374 37 antigen antigen NN cord-010119-t1x9gknd 1374 38 ) ) -RRB- cord-010119-t1x9gknd 1374 39 and and CC cord-010119-t1x9gknd 1374 40 the the DT cord-010119-t1x9gknd 1374 41 expected expect VBN cord-010119-t1x9gknd 1374 42 fraction fraction NN cord-010119-t1x9gknd 1374 43 of of IN cord-010119-t1x9gknd 1374 44 donors donor NNS cord-010119-t1x9gknd 1374 45 expressing express VBG cord-010119-t1x9gknd 1374 46 that that DT cord-010119-t1x9gknd 1374 47 antigen antigen NN cord-010119-t1x9gknd 1374 48 . . . cord-010119-t1x9gknd 1375 1 Study Study NNP cord-010119-t1x9gknd 1375 2 Design Design NNP cord-010119-t1x9gknd 1375 3 / / SYM cord-010119-t1x9gknd 1375 4 Method method NN cord-010119-t1x9gknd 1375 5 : : : cord-010119-t1x9gknd 1376 1 We -PRON- PRP cord-010119-t1x9gknd 1376 2 define define VBP cord-010119-t1x9gknd 1376 3 immunogenicity immunogenicity NN cord-010119-t1x9gknd 1376 4 , , , cord-010119-t1x9gknd 1376 5 or or CC cord-010119-t1x9gknd 1376 6 sensitization sensitization NN cord-010119-t1x9gknd 1376 7 risk risk NN cord-010119-t1x9gknd 1376 8 , , , cord-010119-t1x9gknd 1376 9 r r NNP cord-010119-t1x9gknd 1376 10 , , , cord-010119-t1x9gknd 1376 11 for for IN cord-010119-t1x9gknd 1376 12 any any DT cord-010119-t1x9gknd 1376 13 antigen antigen NN cord-010119-t1x9gknd 1376 14 ( ( -LRB- cord-010119-t1x9gknd 1376 15 " " `` cord-010119-t1x9gknd 1376 16 Ag Ag NNP cord-010119-t1x9gknd 1376 17 " " '' cord-010119-t1x9gknd 1376 18 ) ) -RRB- cord-010119-t1x9gknd 1376 19 of of IN cord-010119-t1x9gknd 1376 20 interest interest NN cord-010119-t1x9gknd 1376 21 , , , cord-010119-t1x9gknd 1376 22 as as IN cord-010119-t1x9gknd 1376 23 the the DT cord-010119-t1x9gknd 1376 24 conditional conditional JJ cord-010119-t1x9gknd 1376 25 probability probability NN cord-010119-t1x9gknd 1376 26 of of IN cord-010119-t1x9gknd 1376 27 alloantibody alloantibody NN cord-010119-t1x9gknd 1376 28 ( ( -LRB- cord-010119-t1x9gknd 1376 29 " " `` cord-010119-t1x9gknd 1376 30 Ab Ab NNP cord-010119-t1x9gknd 1376 31 " " '' cord-010119-t1x9gknd 1376 32 ) ) -RRB- cord-010119-t1x9gknd 1376 33 formation formation NN cord-010119-t1x9gknd 1376 34 , , , cord-010119-t1x9gknd 1376 35 given give VBN cord-010119-t1x9gknd 1376 36 allo allo NN cord-010119-t1x9gknd 1376 37 - - HYPH cord-010119-t1x9gknd 1376 38 exposure exposure NN cord-010119-t1x9gknd 1376 39 to to IN cord-010119-t1x9gknd 1376 40 Ag Ag NNP cord-010119-t1x9gknd 1376 41 , , , cord-010119-t1x9gknd 1376 42 i.e. i.e. FW cord-010119-t1x9gknd 1376 43 r r NN cord-010119-t1x9gknd 1376 44 : : : cord-010119-t1x9gknd 1376 45 5 5 CD cord-010119-t1x9gknd 1376 46 prob(Ab|al prob(ab|al CD cord-010119-t1x9gknd 1376 47 - - HYPH cord-010119-t1x9gknd 1376 48 loExp loexp NN cord-010119-t1x9gknd 1376 49 ) ) -RRB- cord-010119-t1x9gknd 1376 50 , , , cord-010119-t1x9gknd 1376 51 so so IN cord-010119-t1x9gknd 1376 52 that that IN cord-010119-t1x9gknd 1376 53 prob(Ab prob(Ab NNP cord-010119-t1x9gknd 1376 54 ) ) -RRB- cord-010119-t1x9gknd 1377 1 5 5 LS cord-010119-t1x9gknd 1377 2 prob(Ab|alloExp)*prob(alloExp prob(Ab|alloExp)*prob(alloExp NNS cord-010119-t1x9gknd 1377 3 ) ) -RRB- cord-010119-t1x9gknd 1377 4 and and CC cord-010119-t1x9gknd 1377 5 0 0 CD cord-010119-t1x9gknd 1377 6 r r NN cord-010119-t1x9gknd 1377 7 1 1 CD cord-010119-t1x9gknd 1377 8 ; ; , cord-010119-t1x9gknd 1377 9 rewriting rewrite VBG cord-010119-t1x9gknd 1377 10 prob(alloExp prob(alloexp NN cord-010119-t1x9gknd 1377 11 ) ) -RRB- cord-010119-t1x9gknd 1378 1 5 5 LS cord-010119-t1x9gknd 1378 2 prob(Recipient prob(recipient CD cord-010119-t1x9gknd 1378 3 , , , cord-010119-t1x9gknd 1378 4 " " `` cord-010119-t1x9gknd 1378 5 R R NNP cord-010119-t1x9gknd 1378 6 " " '' cord-010119-t1x9gknd 1378 7 , , , cord-010119-t1x9gknd 1378 8 lacks lack VBZ cord-010119-t1x9gknd 1378 9 Ag)*prob(Donor ag)*prob(donor NN cord-010119-t1x9gknd 1378 10 , , , cord-010119-t1x9gknd 1378 11 " " `` cord-010119-t1x9gknd 1378 12 D D NNP cord-010119-t1x9gknd 1378 13 " " '' cord-010119-t1x9gknd 1378 14 has have VBZ cord-010119-t1x9gknd 1378 15 Ag Ag NNP cord-010119-t1x9gknd 1378 16 ) ) -RRB- cord-010119-t1x9gknd 1378 17 ; ; : cord-010119-t1x9gknd 1378 18 and and CC cord-010119-t1x9gknd 1378 19 estimating estimate VBG cord-010119-t1x9gknd 1378 20 prob(Ab prob(Ab NNP cord-010119-t1x9gknd 1378 21 ) ) -RRB- cord-010119-t1x9gknd 1379 1 5 5 CD cord-010119-t1x9gknd 1379 2 nAb nAb NNPS cord-010119-t1x9gknd 1379 3 / / SYM cord-010119-t1x9gknd 1379 4 nR nr XX cord-010119-t1x9gknd 1379 5 , , , cord-010119-t1x9gknd 1380 1 nAb nab VB cord-010119-t1x9gknd 1380 2 denoting denote VBG cord-010119-t1x9gknd 1380 3 the the DT cord-010119-t1x9gknd 1380 4 number number NN cord-010119-t1x9gknd 1380 5 of of IN cord-010119-t1x9gknd 1380 6 Ab Ab NNP cord-010119-t1x9gknd 1380 7 in in IN cord-010119-t1x9gknd 1380 8 nR nr CD cord-010119-t1x9gknd 1380 9 recipients recipient NNS cord-010119-t1x9gknd 1380 10 , , , cord-010119-t1x9gknd 1380 11 we -PRON- PRP cord-010119-t1x9gknd 1380 12 obtain obtain VBP cord-010119-t1x9gknd 1380 13 : : : cord-010119-t1x9gknd 1380 14 nAb/(nR*prob(R nAb/(nR*prob(R NNP cord-010119-t1x9gknd 1380 15 lacks lack VBZ cord-010119-t1x9gknd 1380 16 Ag Ag NNP cord-010119-t1x9gknd 1380 17 ) ) -RRB- cord-010119-t1x9gknd 1380 18 ) ) -RRB- cord-010119-t1x9gknd 1381 1 5 5 LS cord-010119-t1x9gknd 1381 2 r r NN cord-010119-t1x9gknd 1381 3 * * NFP cord-010119-t1x9gknd 1381 4 prob(D prob(D NNP cord-010119-t1x9gknd 1381 5 has have VBZ cord-010119-t1x9gknd 1381 6 Ag Ag NNP cord-010119-t1x9gknd 1381 7 ) ) -RRB- cord-010119-t1x9gknd 1381 8 , , , cord-010119-t1x9gknd 1381 9 the the DT cord-010119-t1x9gknd 1381 10 left left JJ cord-010119-t1x9gknd 1381 11 - - HYPH cord-010119-t1x9gknd 1381 12 hand hand NN cord-010119-t1x9gknd 1381 13 side side NN cord-010119-t1x9gknd 1381 14 representing represent VBG cord-010119-t1x9gknd 1381 15 the the DT cord-010119-t1x9gknd 1381 16 observed observed JJ cord-010119-t1x9gknd 1381 17 sensitized sensitize VBN cord-010119-t1x9gknd 1381 18 fraction fraction NN cord-010119-t1x9gknd 1381 19 , , , cord-010119-t1x9gknd 1381 20 U U NNP cord-010119-t1x9gknd 1381 21 , , , cord-010119-t1x9gknd 1381 22 i.e. i.e. FW cord-010119-t1x9gknd 1381 23 the the DT cord-010119-t1x9gknd 1381 24 number number NN cord-010119-t1x9gknd 1381 25 of of IN cord-010119-t1x9gknd 1381 26 observed observe VBN cord-010119-t1x9gknd 1381 27 Ab Ab NNP cord-010119-t1x9gknd 1381 28 in in IN cord-010119-t1x9gknd 1381 29 relation relation NN cord-010119-t1x9gknd 1381 30 to to IN cord-010119-t1x9gknd 1381 31 the the DT cord-010119-t1x9gknd 1381 32 number number NN cord-010119-t1x9gknd 1381 33 of of IN cord-010119-t1x9gknd 1381 34 recipients recipient NNS cord-010119-t1x9gknd 1381 35 at at IN cord-010119-t1x9gknd 1381 36 risk risk NN cord-010119-t1x9gknd 1381 37 . . . cord-010119-t1x9gknd 1382 1 Conclusion conclusion NN cord-010119-t1x9gknd 1382 2 : : : cord-010119-t1x9gknd 1383 1 Several several JJ cord-010119-t1x9gknd 1383 2 antigens antigen NNS cord-010119-t1x9gknd 1383 3 , , , cord-010119-t1x9gknd 1383 4 though though IN cord-010119-t1x9gknd 1383 5 corresponding correspond VBG cord-010119-t1x9gknd 1383 6 antibodies antibody NNS cord-010119-t1x9gknd 1383 7 may may MD cord-010119-t1x9gknd 1383 8 be be VB cord-010119-t1x9gknd 1383 9 rare rare JJ cord-010119-t1x9gknd 1383 10 ( ( -LRB- cord-010119-t1x9gknd 1383 11 e.g. e.g. RB cord-010119-t1x9gknd 1383 12 " " `` cord-010119-t1x9gknd 1383 13 Jsa Jsa NNP cord-010119-t1x9gknd 1383 14 " " '' cord-010119-t1x9gknd 1383 15 , , , cord-010119-t1x9gknd 1383 16 " " `` cord-010119-t1x9gknd 1383 17 e e NNP cord-010119-t1x9gknd 1383 18 " " '' cord-010119-t1x9gknd 1383 19 , , , cord-010119-t1x9gknd 1383 20 " " `` cord-010119-t1x9gknd 1383 21 U U NNP cord-010119-t1x9gknd 1383 22 " " '' cord-010119-t1x9gknd 1383 23 ) ) -RRB- cord-010119-t1x9gknd 1383 24 , , , cord-010119-t1x9gknd 1383 25 nevertheless nevertheless RB cord-010119-t1x9gknd 1383 26 are be VBP cord-010119-t1x9gknd 1383 27 highly highly RB cord-010119-t1x9gknd 1383 28 immunogenic immunogenic JJ cord-010119-t1x9gknd 1383 29 , , , cord-010119-t1x9gknd 1383 30 requiring require VBG cord-010119-t1x9gknd 1383 31 only only RB cord-010119-t1x9gknd 1383 32 a a DT cord-010119-t1x9gknd 1383 33 single single JJ cord-010119-t1x9gknd 1383 34 exposure exposure NN cord-010119-t1x9gknd 1383 35 ( ( -LRB- cord-010119-t1x9gknd 1383 36 on on IN cord-010119-t1x9gknd 1383 37 average average JJ cord-010119-t1x9gknd 1383 38 ) ) -RRB- cord-010119-t1x9gknd 1383 39 for for IN cord-010119-t1x9gknd 1383 40 sensitization sensitization NN cord-010119-t1x9gknd 1383 41 ; ; : cord-010119-t1x9gknd 1383 42 in in IN cord-010119-t1x9gknd 1383 43 contrast contrast NN cord-010119-t1x9gknd 1383 44 , , , cord-010119-t1x9gknd 1383 45 others other NNS cord-010119-t1x9gknd 1383 46 ( ( -LRB- cord-010119-t1x9gknd 1383 47 on on IN cord-010119-t1x9gknd 1383 48 average average JJ cord-010119-t1x9gknd 1383 49 ) ) -RRB- cord-010119-t1x9gknd 1383 50 will will MD cord-010119-t1x9gknd 1383 51 require require VB cord-010119-t1x9gknd 1383 52 many many JJ cord-010119-t1x9gknd 1383 53 exposures exposure NNS cord-010119-t1x9gknd 1383 54 and and CC cord-010119-t1x9gknd 1383 55 thus thus RB cord-010119-t1x9gknd 1383 56 pose pose VBP cord-010119-t1x9gknd 1383 57 a a DT cord-010119-t1x9gknd 1383 58 relatively relatively RB cord-010119-t1x9gknd 1383 59 low low JJ cord-010119-t1x9gknd 1383 60 risk risk NN cord-010119-t1x9gknd 1383 61 . . . cord-010119-t1x9gknd 1384 1 In in IN cord-010119-t1x9gknd 1384 2 conjunction conjunction NN cord-010119-t1x9gknd 1384 3 with with IN cord-010119-t1x9gknd 1384 4 patient patient JJ cord-010119-t1x9gknd 1384 5 genotypes genotype NNS cord-010119-t1x9gknd 1384 6 , , , cord-010119-t1x9gknd 1384 7 our -PRON- PRP$ cord-010119-t1x9gknd 1384 8 r r NN cord-010119-t1x9gknd 1384 9 -scale -scale NN cord-010119-t1x9gknd 1384 10 will will MD cord-010119-t1x9gknd 1384 11 facilitate facilitate VB cord-010119-t1x9gknd 1384 12 the the DT cord-010119-t1x9gknd 1384 13 selection selection NN cord-010119-t1x9gknd 1384 14 of of IN cord-010119-t1x9gknd 1384 15 patient patient NN cord-010119-t1x9gknd 1384 16 - - HYPH cord-010119-t1x9gknd 1384 17 specific specific JJ cord-010119-t1x9gknd 1384 18 cells cell NNS cord-010119-t1x9gknd 1384 19 so so IN cord-010119-t1x9gknd 1384 20 as as IN cord-010119-t1x9gknd 1384 21 to to TO cord-010119-t1x9gknd 1384 22 minimize minimize VB cord-010119-t1x9gknd 1384 23 the the DT cord-010119-t1x9gknd 1384 24 risk risk NN cord-010119-t1x9gknd 1384 25 of of IN cord-010119-t1x9gknd 1384 26 ( ( -LRB- cord-010119-t1x9gknd 1384 27 proliferating proliferate VBG cord-010119-t1x9gknd 1384 28 ) ) -RRB- cord-010119-t1x9gknd 1384 29 alloimmunization alloimmunization NN cord-010119-t1x9gknd 1384 30 even even RB cord-010119-t1x9gknd 1384 31 when when WRB cord-010119-t1x9gknd 1384 32 perfectly perfectly RB cord-010119-t1x9gknd 1384 33 matched match VBN cord-010119-t1x9gknd 1384 34 cells cell NNS cord-010119-t1x9gknd 1384 35 are be VBP cord-010119-t1x9gknd 1384 36 not not RB cord-010119-t1x9gknd 1384 37 available available JJ cord-010119-t1x9gknd 1384 38 . . . cord-010119-t1x9gknd 1385 1 Our -PRON- PRP$ cord-010119-t1x9gknd 1385 2 approach approach NN cord-010119-t1x9gknd 1385 3 may may MD cord-010119-t1x9gknd 1385 4 be be VB cord-010119-t1x9gknd 1385 5 readily readily RB cord-010119-t1x9gknd 1385 6 extended extend VBN cord-010119-t1x9gknd 1385 7 to to IN cord-010119-t1x9gknd 1385 8 additional additional JJ cord-010119-t1x9gknd 1385 9 RBC RBC NNP cord-010119-t1x9gknd 1385 10 antigens antigen NNS cord-010119-t1x9gknd 1385 11 and and CC cord-010119-t1x9gknd 1385 12 other other JJ cord-010119-t1x9gknd 1385 13 antigen antigen NN cord-010119-t1x9gknd 1385 14 systems system NNS cord-010119-t1x9gknd 1385 15 . . . cord-010119-t1x9gknd 1386 1 Background Background NNP cord-010119-t1x9gknd 1386 2 / / SYM cord-010119-t1x9gknd 1386 3 Case Case NNP cord-010119-t1x9gknd 1386 4 Studies Studies NNPS cord-010119-t1x9gknd 1386 5 : : : cord-010119-t1x9gknd 1387 1 AABB AABB NNP cord-010119-t1x9gknd 1387 2 and and CC cord-010119-t1x9gknd 1387 3 FDA FDA NNP cord-010119-t1x9gknd 1387 4 require require VBP cord-010119-t1x9gknd 1387 5 a a DT cord-010119-t1x9gknd 1387 6 12 12 CD cord-010119-t1x9gknd 1387 7 month month NN cord-010119-t1x9gknd 1387 8 deferral deferral NN cord-010119-t1x9gknd 1387 9 of of IN cord-010119-t1x9gknd 1387 10 donors donor NNS cord-010119-t1x9gknd 1387 11 with with IN cord-010119-t1x9gknd 1387 12 a a DT cord-010119-t1x9gknd 1387 13 tattoo tattoo NN cord-010119-t1x9gknd 1387 14 applied apply VBN cord-010119-t1x9gknd 1387 15 using use VBG cord-010119-t1x9gknd 1387 16 non non JJ cord-010119-t1x9gknd 1387 17 - - JJ cord-010119-t1x9gknd 1387 18 sterile sterile JJ cord-010119-t1x9gknd 1387 19 needles needle NNS cord-010119-t1x9gknd 1387 20 or or CC cord-010119-t1x9gknd 1387 21 reusable reusable JJ cord-010119-t1x9gknd 1387 22 ink ink NN cord-010119-t1x9gknd 1387 23 . . . cord-010119-t1x9gknd 1388 1 We -PRON- PRP cord-010119-t1x9gknd 1388 2 review review VBP cord-010119-t1x9gknd 1388 3 state state NN cord-010119-t1x9gknd 1388 4 regulations regulation NNS cord-010119-t1x9gknd 1388 5 to to TO cord-010119-t1x9gknd 1388 6 ascertain ascertain VB cord-010119-t1x9gknd 1388 7 if if IN cord-010119-t1x9gknd 1388 8 tattoo tattoo NN cord-010119-t1x9gknd 1388 9 establishments establishment NNS cord-010119-t1x9gknd 1388 10 are be VBP cord-010119-t1x9gknd 1388 11 licensed license VBN cord-010119-t1x9gknd 1388 12 and and CC cord-010119-t1x9gknd 1388 13 required require VBN cord-010119-t1x9gknd 1388 14 to to TO cord-010119-t1x9gknd 1388 15 use use VB cord-010119-t1x9gknd 1388 16 sterile sterile JJ cord-010119-t1x9gknd 1388 17 or or CC cord-010119-t1x9gknd 1388 18 single single JJ cord-010119-t1x9gknd 1388 19 - - HYPH cord-010119-t1x9gknd 1388 20 use use NN cord-010119-t1x9gknd 1388 21 needles needle NNS cord-010119-t1x9gknd 1388 22 and and CC cord-010119-t1x9gknd 1388 23 single single JJ cord-010119-t1x9gknd 1388 24 - - HYPH cord-010119-t1x9gknd 1388 25 use use NN cord-010119-t1x9gknd 1388 26 ink ink NN cord-010119-t1x9gknd 1388 27 . . . cord-010119-t1x9gknd 1389 1 We -PRON- PRP cord-010119-t1x9gknd 1389 2 recently recently RB cord-010119-t1x9gknd 1389 3 added add VBD cord-010119-t1x9gknd 1389 4 two two CD cord-010119-t1x9gknd 1389 5 large large JJ cord-010119-t1x9gknd 1389 6 states state NNS cord-010119-t1x9gknd 1389 7 in in IN cord-010119-t1x9gknd 1389 8 which which WDT cord-010119-t1x9gknd 1389 9 we -PRON- PRP cord-010119-t1x9gknd 1389 10 collect collect VBP cord-010119-t1x9gknd 1389 11 blood blood NN cord-010119-t1x9gknd 1389 12 to to IN cord-010119-t1x9gknd 1389 13 the the DT cord-010119-t1x9gknd 1389 14 Acceptable acceptable JJ cord-010119-t1x9gknd 1389 15 States States NNP cord-010119-t1x9gknd 1389 16 List List NNP cord-010119-t1x9gknd 1389 17 ( ( -LRB- cord-010119-t1x9gknd 1389 18 ASL ASL NNP cord-010119-t1x9gknd 1389 19 ) ) -RRB- cord-010119-t1x9gknd 1389 20 . . . cord-010119-t1x9gknd 1390 1 We -PRON- PRP cord-010119-t1x9gknd 1390 2 compared compare VBD cord-010119-t1x9gknd 1390 3 the the DT cord-010119-t1x9gknd 1390 4 rates rate NNS cord-010119-t1x9gknd 1390 5 of of IN cord-010119-t1x9gknd 1390 6 donors donor NNS cord-010119-t1x9gknd 1390 7 deferred defer VBN cord-010119-t1x9gknd 1390 8 before before IN cord-010119-t1x9gknd 1390 9 and and CC cord-010119-t1x9gknd 1390 10 after after IN cord-010119-t1x9gknd 1390 11 the the DT cord-010119-t1x9gknd 1390 12 addition addition NN cord-010119-t1x9gknd 1390 13 of of IN cord-010119-t1x9gknd 1390 14 these these DT cord-010119-t1x9gknd 1390 15 states state NNS cord-010119-t1x9gknd 1390 16 to to TO cord-010119-t1x9gknd 1390 17 determine determine VB cord-010119-t1x9gknd 1390 18 potential potential JJ cord-010119-t1x9gknd 1390 19 donor donor NN cord-010119-t1x9gknd 1390 20 gain gain NN cord-010119-t1x9gknd 1390 21 with with IN cord-010119-t1x9gknd 1390 22 changes change NNS cord-010119-t1x9gknd 1390 23 in in IN cord-010119-t1x9gknd 1390 24 state state NN cord-010119-t1x9gknd 1390 25 tattoo tattoo NN cord-010119-t1x9gknd 1390 26 licensing licensing NN cord-010119-t1x9gknd 1390 27 regulations regulation NNS cord-010119-t1x9gknd 1390 28 . . . cord-010119-t1x9gknd 1391 1 Study Study NNP cord-010119-t1x9gknd 1391 2 Design Design NNP cord-010119-t1x9gknd 1391 3 / / SYM cord-010119-t1x9gknd 1391 4 Method method NN cord-010119-t1x9gknd 1391 5 : : : cord-010119-t1x9gknd 1391 6 We -PRON- PRP cord-010119-t1x9gknd 1391 7 analyzed analyze VBD cord-010119-t1x9gknd 1391 8 allogeneic allogeneic IN cord-010119-t1x9gknd 1391 9 interview interview NN cord-010119-t1x9gknd 1391 10 responses response NNS cord-010119-t1x9gknd 1391 11 to to IN cord-010119-t1x9gknd 1391 12 the the DT cord-010119-t1x9gknd 1391 13 screening screening NN cord-010119-t1x9gknd 1391 14 question question NN cord-010119-t1x9gknd 1391 15 , , , cord-010119-t1x9gknd 1391 16 " " `` cord-010119-t1x9gknd 1391 17 In in IN cord-010119-t1x9gknd 1391 18 the the DT cord-010119-t1x9gknd 1391 19 past past JJ cord-010119-t1x9gknd 1391 20 12 12 CD cord-010119-t1x9gknd 1391 21 months month NNS cord-010119-t1x9gknd 1391 22 have have VBP cord-010119-t1x9gknd 1391 23 you -PRON- PRP cord-010119-t1x9gknd 1391 24 had have VBN cord-010119-t1x9gknd 1391 25 a a DT cord-010119-t1x9gknd 1391 26 tattoo tattoo NN cord-010119-t1x9gknd 1391 27 ? ? . cord-010119-t1x9gknd 1391 28 " " '' cord-010119-t1x9gknd 1392 1 and and CC cord-010119-t1x9gknd 1392 2 if if IN cord-010119-t1x9gknd 1392 3 ' ' `` cord-010119-t1x9gknd 1392 4 yes yes UH cord-010119-t1x9gknd 1392 5 ' ' '' cord-010119-t1x9gknd 1392 6 , , , cord-010119-t1x9gknd 1392 7 whether whether IN cord-010119-t1x9gknd 1392 8 the the DT cord-010119-t1x9gknd 1392 9 tattoo tattoo NN cord-010119-t1x9gknd 1392 10 was be VBD cord-010119-t1x9gknd 1392 11 applied apply VBN cord-010119-t1x9gknd 1392 12 by by IN cord-010119-t1x9gknd 1392 13 a a DT cord-010119-t1x9gknd 1392 14 state state NN cord-010119-t1x9gknd 1392 15 regulated regulate VBN cord-010119-t1x9gknd 1392 16 entity entity NN cord-010119-t1x9gknd 1392 17 . . . cord-010119-t1x9gknd 1393 1 Blood blood NN cord-010119-t1x9gknd 1393 2 centers center NNS cord-010119-t1x9gknd 1393 3 in in IN cord-010119-t1x9gknd 1393 4 2 2 CD cord-010119-t1x9gknd 1393 5 states state NNS cord-010119-t1x9gknd 1393 6 were be VBD cord-010119-t1x9gknd 1393 7 selected select VBN cord-010119-t1x9gknd 1393 8 for for IN cord-010119-t1x9gknd 1393 9 the the DT cord-010119-t1x9gknd 1393 10 analysis analysis NN cord-010119-t1x9gknd 1393 11 before before IN cord-010119-t1x9gknd 1393 12 and and CC cord-010119-t1x9gknd 1393 13 after after IN cord-010119-t1x9gknd 1393 14 state state NN cord-010119-t1x9gknd 1393 15 tattoo tattoo NN cord-010119-t1x9gknd 1393 16 regulation regulation NN cord-010119-t1x9gknd 1393 17 . . . cord-010119-t1x9gknd 1394 1 In in IN cord-010119-t1x9gknd 1394 2 State State NNP cord-010119-t1x9gknd 1394 3 A A NNP cord-010119-t1x9gknd 1394 4 , , , cord-010119-t1x9gknd 1394 5 a a DT cord-010119-t1x9gknd 1394 6 comparison comparison NN cord-010119-t1x9gknd 1394 7 period period NN cord-010119-t1x9gknd 1394 8 of of IN cord-010119-t1x9gknd 1394 9 similar similar JJ cord-010119-t1x9gknd 1394 10 3 3 CD cord-010119-t1x9gknd 1394 11 months month NNS cord-010119-t1x9gknd 1394 12 before before RB cord-010119-t1x9gknd 1394 13 ( ( -LRB- cord-010119-t1x9gknd 1394 14 2/ 2/ CD cord-010119-t1x9gknd 1394 15 2015 2015 CD cord-010119-t1x9gknd 1394 16 -4/2015 -4/2015 NFP cord-010119-t1x9gknd 1394 17 ) ) -RRB- cord-010119-t1x9gknd 1394 18 and and CC cord-010119-t1x9gknd 1394 19 3 3 CD cord-010119-t1x9gknd 1394 20 months month NNS cord-010119-t1x9gknd 1394 21 after after IN cord-010119-t1x9gknd 1394 22 ( ( -LRB- cord-010119-t1x9gknd 1394 23 2/2016 2/2016 RB cord-010119-t1x9gknd 1394 24 -4/2016 -4/2016 JJS cord-010119-t1x9gknd 1394 25 ) ) -RRB- cord-010119-t1x9gknd 1394 26 was be VBD cord-010119-t1x9gknd 1394 27 selected select VBN cord-010119-t1x9gknd 1394 28 ; ; : cord-010119-t1x9gknd 1394 29 for for IN cord-010119-t1x9gknd 1394 30 State State NNP cord-010119-t1x9gknd 1394 31 B B NNP cord-010119-t1x9gknd 1394 32 , , , cord-010119-t1x9gknd 1394 33 a a DT cord-010119-t1x9gknd 1394 34 similar similar JJ cord-010119-t1x9gknd 1394 35 4 4 CD cord-010119-t1x9gknd 1394 36 months month NNS cord-010119-t1x9gknd 1394 37 before before RB cord-010119-t1x9gknd 1394 38 ( ( -LRB- cord-010119-t1x9gknd 1394 39 12/2015 12/2015 CD cord-010119-t1x9gknd 1394 40 -3/2016 -3/2016 JJS cord-010119-t1x9gknd 1394 41 ) ) -RRB- cord-010119-t1x9gknd 1394 42 and and CC cord-010119-t1x9gknd 1394 43 4 4 CD cord-010119-t1x9gknd 1394 44 months month NNS cord-010119-t1x9gknd 1394 45 after after IN cord-010119-t1x9gknd 1394 46 ( ( -LRB- cord-010119-t1x9gknd 1394 47 12/2016 12/2016 CD cord-010119-t1x9gknd 1394 48 -3/2017 -3/2017 CD cord-010119-t1x9gknd 1394 49 ) ) -RRB- cord-010119-t1x9gknd 1394 50 was be VBD cord-010119-t1x9gknd 1394 51 selected select VBN cord-010119-t1x9gknd 1394 52 . . . cord-010119-t1x9gknd 1395 1 Frequency frequency NN cord-010119-t1x9gknd 1395 2 and and CC cord-010119-t1x9gknd 1395 3 rate rate NN cord-010119-t1x9gknd 1395 4 of of IN cord-010119-t1x9gknd 1395 5 responses response NNS cord-010119-t1x9gknd 1395 6 were be VBD cord-010119-t1x9gknd 1395 7 compared compare VBN cord-010119-t1x9gknd 1395 8 in in RP cord-010119-t1x9gknd 1395 9 before before RB cord-010119-t1x9gknd 1395 10 and and CC cord-010119-t1x9gknd 1395 11 after after IN cord-010119-t1x9gknd 1395 12 periods period NNS cord-010119-t1x9gknd 1395 13 . . . cord-010119-t1x9gknd 1396 1 Among among IN cord-010119-t1x9gknd 1396 2 those those DT cord-010119-t1x9gknd 1396 3 who who WP cord-010119-t1x9gknd 1396 4 responded respond VBD cord-010119-t1x9gknd 1396 5 to to IN cord-010119-t1x9gknd 1396 6 having have VBG cord-010119-t1x9gknd 1396 7 a a DT cord-010119-t1x9gknd 1396 8 tattoo tattoo NN cord-010119-t1x9gknd 1396 9 in in IN cord-010119-t1x9gknd 1396 10 a a DT cord-010119-t1x9gknd 1396 11 regulated regulated JJ cord-010119-t1x9gknd 1396 12 state state NN cord-010119-t1x9gknd 1396 13 , , , cord-010119-t1x9gknd 1396 14 donations donation NNS cord-010119-t1x9gknd 1396 15 were be VBD cord-010119-t1x9gknd 1396 16 reviewed review VBN cord-010119-t1x9gknd 1396 17 for for IN cord-010119-t1x9gknd 1396 18 presence presence NN cord-010119-t1x9gknd 1396 19 of of IN cord-010119-t1x9gknd 1396 20 infectious infectious JJ cord-010119-t1x9gknd 1396 21 disease disease NN cord-010119-t1x9gknd 1396 22 markers marker NNS cord-010119-t1x9gknd 1396 23 including include VBG cord-010119-t1x9gknd 1396 24 HIV HIV NNP cord-010119-t1x9gknd 1396 25 , , , cord-010119-t1x9gknd 1396 26 HBV HBV NNP cord-010119-t1x9gknd 1396 27 and and CC cord-010119-t1x9gknd 1396 28 HCV HCV NNP cord-010119-t1x9gknd 1396 29 . . . cord-010119-t1x9gknd 1397 1 Results/ Results/ . cord-010119-t1x9gknd 1398 1 Finding finding NN cord-010119-t1x9gknd 1398 2 : : : cord-010119-t1x9gknd 1399 1 A a DT cord-010119-t1x9gknd 1399 2 higher high JJR cord-010119-t1x9gknd 1399 3 proportion proportion NN cord-010119-t1x9gknd 1399 4 of of IN cord-010119-t1x9gknd 1399 5 donors donor NNS cord-010119-t1x9gknd 1399 6 presenting present VBG cord-010119-t1x9gknd 1399 7 to to TO cord-010119-t1x9gknd 1399 8 give give VB cord-010119-t1x9gknd 1399 9 blood blood NN cord-010119-t1x9gknd 1399 10 admitted admit VBN cord-010119-t1x9gknd 1399 11 to to IN cord-010119-t1x9gknd 1399 12 having have VBG cord-010119-t1x9gknd 1399 13 a a DT cord-010119-t1x9gknd 1399 14 recent recent JJ cord-010119-t1x9gknd 1399 15 ( ( -LRB- cord-010119-t1x9gknd 1399 16 < < NNP cord-010119-t1x9gknd 1399 17 12 12 CD cord-010119-t1x9gknd 1399 18 months month NNS cord-010119-t1x9gknd 1399 19 ) ) -RRB- cord-010119-t1x9gknd 1399 20 tattoo tattoo NN cord-010119-t1x9gknd 1399 21 in in IN cord-010119-t1x9gknd 1399 22 the the DT cord-010119-t1x9gknd 1399 23 post post JJ cord-010119-t1x9gknd 1399 24 period period NN cord-010119-t1x9gknd 1399 25 in in IN cord-010119-t1x9gknd 1399 26 both both DT cord-010119-t1x9gknd 1399 27 states state NNS cord-010119-t1x9gknd 1399 28 . . . cord-010119-t1x9gknd 1400 1 This this DT cord-010119-t1x9gknd 1400 2 increase increase NN cord-010119-t1x9gknd 1400 3 occurred occur VBD cord-010119-t1x9gknd 1400 4 immediately immediately RB cord-010119-t1x9gknd 1400 5 following follow VBG cord-010119-t1x9gknd 1400 6 the the DT cord-010119-t1x9gknd 1400 7 addition addition NN cord-010119-t1x9gknd 1400 8 of of IN cord-010119-t1x9gknd 1400 9 States States NNP cord-010119-t1x9gknd 1400 10 A A NNP cord-010119-t1x9gknd 1400 11 and and CC cord-010119-t1x9gknd 1400 12 B b NN cord-010119-t1x9gknd 1400 13 to to IN cord-010119-t1x9gknd 1400 14 the the DT cord-010119-t1x9gknd 1400 15 ASL ASL NNP cord-010119-t1x9gknd 1400 16 ( ( -LRB- cord-010119-t1x9gknd 1400 17 data datum NNS cord-010119-t1x9gknd 1400 18 not not RB cord-010119-t1x9gknd 1400 19 shown show VBN cord-010119-t1x9gknd 1400 20 ) ) -RRB- cord-010119-t1x9gknd 1400 21 . . . cord-010119-t1x9gknd 1401 1 Among among IN cord-010119-t1x9gknd 1401 2 those those DT cord-010119-t1x9gknd 1401 3 who who WP cord-010119-t1x9gknd 1401 4 responded respond VBD cord-010119-t1x9gknd 1401 5 yes yes UH cord-010119-t1x9gknd 1401 6 to to IN cord-010119-t1x9gknd 1401 7 having have VBG cord-010119-t1x9gknd 1401 8 a a DT cord-010119-t1x9gknd 1401 9 tattoo tattoo NN cord-010119-t1x9gknd 1401 10 , , , cord-010119-t1x9gknd 1401 11 in in IN cord-010119-t1x9gknd 1401 12 States States NNP cord-010119-t1x9gknd 1401 13 A A NNP cord-010119-t1x9gknd 1401 14 and and CC cord-010119-t1x9gknd 1401 15 B b NN cord-010119-t1x9gknd 1401 16 respectively respectively RB cord-010119-t1x9gknd 1401 17 , , , cord-010119-t1x9gknd 1401 18 there there EX cord-010119-t1x9gknd 1401 19 was be VBD cord-010119-t1x9gknd 1401 20 a a DT cord-010119-t1x9gknd 1401 21 13-and 13-and CD cord-010119-t1x9gknd 1401 22 3-fold 3-fold CD cord-010119-t1x9gknd 1401 23 increase increase NN cord-010119-t1x9gknd 1401 24 in in IN cord-010119-t1x9gknd 1401 25 accepted accept VBN cord-010119-t1x9gknd 1401 26 donors donor NNS cord-010119-t1x9gknd 1401 27 ( ( -LRB- cord-010119-t1x9gknd 1401 28 Table table NN cord-010119-t1x9gknd 1401 29 ) ) -RRB- cord-010119-t1x9gknd 1401 30 . . . cord-010119-t1x9gknd 1402 1 The the DT cord-010119-t1x9gknd 1402 2 absolute absolute JJ cord-010119-t1x9gknd 1402 3 number number NN cord-010119-t1x9gknd 1402 4 of of IN cord-010119-t1x9gknd 1402 5 accepted accept VBN cord-010119-t1x9gknd 1402 6 donors donor NNS cord-010119-t1x9gknd 1402 7 with with IN cord-010119-t1x9gknd 1402 8 tattoos tattoo NNS cord-010119-t1x9gknd 1402 9 increased increase VBD cord-010119-t1x9gknd 1402 10 from from IN cord-010119-t1x9gknd 1402 11 13 13 CD cord-010119-t1x9gknd 1402 12 to to IN cord-010119-t1x9gknd 1402 13 567 567 CD cord-010119-t1x9gknd 1402 14 ( ( -LRB- cord-010119-t1x9gknd 1402 15 State State NNP cord-010119-t1x9gknd 1402 16 A A NNP cord-010119-t1x9gknd 1402 17 ) ) -RRB- cord-010119-t1x9gknd 1402 18 and and CC cord-010119-t1x9gknd 1402 19 151 151 CD cord-010119-t1x9gknd 1402 20 to to IN cord-010119-t1x9gknd 1402 21 1,496 1,496 CD cord-010119-t1x9gknd 1402 22 ( ( -LRB- cord-010119-t1x9gknd 1402 23 State State NNP cord-010119-t1x9gknd 1402 24 B B NNP cord-010119-t1x9gknd 1402 25 ) ) -RRB- cord-010119-t1x9gknd 1402 26 , , , cord-010119-t1x9gknd 1402 27 which which WDT cord-010119-t1x9gknd 1402 28 annualized annualize VBD cord-010119-t1x9gknd 1402 29 , , , cord-010119-t1x9gknd 1402 30 represents represent VBZ cord-010119-t1x9gknd 1402 31 a a DT cord-010119-t1x9gknd 1402 32 potential potential JJ cord-010119-t1x9gknd 1402 33 gain gain NN cord-010119-t1x9gknd 1402 34 of of IN cord-010119-t1x9gknd 1402 35 2,216 2,216 CD cord-010119-t1x9gknd 1402 36 ( ( -LRB- cord-010119-t1x9gknd 1402 37 State State NNP cord-010119-t1x9gknd 1402 38 A A NNP cord-010119-t1x9gknd 1402 39 ) ) -RRB- cord-010119-t1x9gknd 1402 40 and and CC cord-010119-t1x9gknd 1402 41 4,035 4,035 CD cord-010119-t1x9gknd 1402 42 ( ( -LRB- cord-010119-t1x9gknd 1402 43 State State NNP cord-010119-t1x9gknd 1402 44 B B NNP cord-010119-t1x9gknd 1402 45 ) ) -RRB- cord-010119-t1x9gknd 1402 46 additional additional JJ cord-010119-t1x9gknd 1402 47 donations donation NNS cord-010119-t1x9gknd 1402 48 . . . cord-010119-t1x9gknd 1403 1 All all DT cord-010119-t1x9gknd 1403 2 donors donor NNS cord-010119-t1x9gknd 1403 3 who who WP cord-010119-t1x9gknd 1403 4 had have VBD cord-010119-t1x9gknd 1403 5 a a DT cord-010119-t1x9gknd 1403 6 tattoo tattoo NN cord-010119-t1x9gknd 1403 7 in in IN cord-010119-t1x9gknd 1403 8 regulated regulated JJ cord-010119-t1x9gknd 1403 9 states state NNS cord-010119-t1x9gknd 1403 10 ( ( -LRB- cord-010119-t1x9gknd 1403 11 ASL ASL NNP cord-010119-t1x9gknd 1403 12 ) ) -RRB- cord-010119-t1x9gknd 1403 13 tested test VBD cord-010119-t1x9gknd 1403 14 negative negative JJ cord-010119-t1x9gknd 1403 15 for for IN cord-010119-t1x9gknd 1403 16 HIV HIV NNP cord-010119-t1x9gknd 1403 17 , , , cord-010119-t1x9gknd 1403 18 HBV HBV NNP cord-010119-t1x9gknd 1403 19 and and CC cord-010119-t1x9gknd 1403 20 HCV HCV NNP cord-010119-t1x9gknd 1403 21 . . . cord-010119-t1x9gknd 1404 1 Conclusion conclusion NN cord-010119-t1x9gknd 1404 2 : : : cord-010119-t1x9gknd 1405 1 To to TO cord-010119-t1x9gknd 1405 2 counter counter VB cord-010119-t1x9gknd 1405 3 rising rise VBG cord-010119-t1x9gknd 1405 4 numbers number NNS cord-010119-t1x9gknd 1405 5 of of IN cord-010119-t1x9gknd 1405 6 ineligible ineligible JJ cord-010119-t1x9gknd 1405 7 donors donor NNS cord-010119-t1x9gknd 1405 8 resulting result VBG cord-010119-t1x9gknd 1405 9 from from IN cord-010119-t1x9gknd 1405 10 recently recently RB cord-010119-t1x9gknd 1405 11 added add VBN cord-010119-t1x9gknd 1405 12 deferrals deferral NNS cord-010119-t1x9gknd 1405 13 , , , cord-010119-t1x9gknd 1405 14 we -PRON- PRP cord-010119-t1x9gknd 1405 15 considered consider VBD cord-010119-t1x9gknd 1405 16 recovery recovery NN cord-010119-t1x9gknd 1405 17 of of IN cord-010119-t1x9gknd 1405 18 donors donor NNS cord-010119-t1x9gknd 1405 19 deferred defer VBN cord-010119-t1x9gknd 1405 20 for for IN cord-010119-t1x9gknd 1405 21 tattoos tattoo NNS cord-010119-t1x9gknd 1405 22 as as IN cord-010119-t1x9gknd 1405 23 a a DT cord-010119-t1x9gknd 1405 24 way way NN cord-010119-t1x9gknd 1405 25 to to TO cord-010119-t1x9gknd 1405 26 enhance enhance VB cord-010119-t1x9gknd 1405 27 our -PRON- PRP$ cord-010119-t1x9gknd 1405 28 donor donor NN cord-010119-t1x9gknd 1405 29 base base NN cord-010119-t1x9gknd 1405 30 . . . cord-010119-t1x9gknd 1406 1 The the DT cord-010119-t1x9gknd 1406 2 immediate immediate JJ cord-010119-t1x9gknd 1406 3 rise rise NN cord-010119-t1x9gknd 1406 4 in in IN cord-010119-t1x9gknd 1406 5 the the DT cord-010119-t1x9gknd 1406 6 number number NN cord-010119-t1x9gknd 1406 7 of of IN cord-010119-t1x9gknd 1406 8 donors donor NNS cord-010119-t1x9gknd 1406 9 reporting report VBG cord-010119-t1x9gknd 1406 10 a a DT cord-010119-t1x9gknd 1406 11 tattoo tattoo NN cord-010119-t1x9gknd 1406 12 following follow VBG cord-010119-t1x9gknd 1406 13 the the DT cord-010119-t1x9gknd 1406 14 addition addition NN cord-010119-t1x9gknd 1406 15 of of IN cord-010119-t1x9gknd 1406 16 the the DT cord-010119-t1x9gknd 1406 17 2 2 CD cord-010119-t1x9gknd 1406 18 states state NNS cord-010119-t1x9gknd 1406 19 may may MD cord-010119-t1x9gknd 1406 20 reflect reflect VB cord-010119-t1x9gknd 1406 21 a a DT cord-010119-t1x9gknd 1406 22 decline decline NN cord-010119-t1x9gknd 1406 23 in in IN cord-010119-t1x9gknd 1406 24 self self NN cord-010119-t1x9gknd 1406 25 - - HYPH cord-010119-t1x9gknd 1406 26 deferrals deferral NNS cord-010119-t1x9gknd 1406 27 based base VBN cord-010119-t1x9gknd 1406 28 on on IN cord-010119-t1x9gknd 1406 29 having have VBG cord-010119-t1x9gknd 1406 30 had have VBN cord-010119-t1x9gknd 1406 31 a a DT cord-010119-t1x9gknd 1406 32 recent recent JJ cord-010119-t1x9gknd 1406 33 tattoo tattoo NN cord-010119-t1x9gknd 1406 34 . . . cord-010119-t1x9gknd 1407 1 We -PRON- PRP cord-010119-t1x9gknd 1407 2 demonstrated demonstrate VBD cord-010119-t1x9gknd 1407 3 an an DT cord-010119-t1x9gknd 1407 4 increase increase NN cord-010119-t1x9gknd 1407 5 in in IN cord-010119-t1x9gknd 1407 6 the the DT cord-010119-t1x9gknd 1407 7 potential potential JJ cord-010119-t1x9gknd 1407 8 number number NN cord-010119-t1x9gknd 1407 9 of of IN cord-010119-t1x9gknd 1407 10 donations donation NNS cord-010119-t1x9gknd 1407 11 without without IN cord-010119-t1x9gknd 1407 12 compromising compromise VBG cord-010119-t1x9gknd 1407 13 safety safety NN cord-010119-t1x9gknd 1407 14 . . . cord-010119-t1x9gknd 1408 1 Background Background NNP cord-010119-t1x9gknd 1408 2 / / SYM cord-010119-t1x9gknd 1408 3 Case Case NNP cord-010119-t1x9gknd 1408 4 Studies Studies NNPS cord-010119-t1x9gknd 1409 1 : : : cord-010119-t1x9gknd 1409 2 Transgender transgender NN cord-010119-t1x9gknd 1409 3 donors donor NNS cord-010119-t1x9gknd 1409 4 represent represent VBP cord-010119-t1x9gknd 1409 5 a a DT cord-010119-t1x9gknd 1409 6 small small JJ cord-010119-t1x9gknd 1409 7 fraction fraction NN cord-010119-t1x9gknd 1409 8 of of IN cord-010119-t1x9gknd 1409 9 blood blood NN cord-010119-t1x9gknd 1409 10 donors donor NNS cord-010119-t1x9gknd 1409 11 . . . cord-010119-t1x9gknd 1410 1 Determining determine VBG cord-010119-t1x9gknd 1410 2 their -PRON- PRP$ cord-010119-t1x9gknd 1410 3 eligibility eligibility NN cord-010119-t1x9gknd 1410 4 to to TO cord-010119-t1x9gknd 1410 5 donate donate VB cord-010119-t1x9gknd 1410 6 has have VBZ cord-010119-t1x9gknd 1410 7 been be VBN cord-010119-t1x9gknd 1410 8 challenging challenge VBG cord-010119-t1x9gknd 1410 9 for for IN cord-010119-t1x9gknd 1410 10 blood blood NN cord-010119-t1x9gknd 1410 11 centers center NNS cord-010119-t1x9gknd 1410 12 . . . cord-010119-t1x9gknd 1411 1 To to TO cord-010119-t1x9gknd 1411 2 assess assess VB cord-010119-t1x9gknd 1411 3 behavioral behavioral JJ cord-010119-t1x9gknd 1411 4 risk risk NN cord-010119-t1x9gknd 1411 5 , , , cord-010119-t1x9gknd 1411 6 the the DT cord-010119-t1x9gknd 1411 7 donor donor NN cord-010119-t1x9gknd 1411 8 is be VBZ cord-010119-t1x9gknd 1411 9 required require VBN cord-010119-t1x9gknd 1411 10 to to TO cord-010119-t1x9gknd 1411 11 answer answer VB cord-010119-t1x9gknd 1411 12 gender gender NN cord-010119-t1x9gknd 1411 13 specific specific JJ cord-010119-t1x9gknd 1411 14 questions question NNS cord-010119-t1x9gknd 1411 15 . . . cord-010119-t1x9gknd 1412 1 The the DT cord-010119-t1x9gknd 1412 2 same same JJ cord-010119-t1x9gknd 1412 3 is be VBZ cord-010119-t1x9gknd 1412 4 true true JJ cord-010119-t1x9gknd 1412 5 when when WRB cord-010119-t1x9gknd 1412 6 assessing assess VBG cord-010119-t1x9gknd 1412 7 TRALI TRALI NNP cord-010119-t1x9gknd 1412 8 risk risk NN cord-010119-t1x9gknd 1412 9 where where WRB cord-010119-t1x9gknd 1412 10 the the DT cord-010119-t1x9gknd 1412 11 donor donor NN cord-010119-t1x9gknd 1412 12 is be VBZ cord-010119-t1x9gknd 1412 13 asked ask VBN cord-010119-t1x9gknd 1412 14 about about IN cord-010119-t1x9gknd 1412 15 a a DT cord-010119-t1x9gknd 1412 16 history history NN cord-010119-t1x9gknd 1412 17 of of IN cord-010119-t1x9gknd 1412 18 prior prior JJ cord-010119-t1x9gknd 1412 19 pregnancies pregnancy NNS cord-010119-t1x9gknd 1412 20 . . . cord-010119-t1x9gknd 1413 1 Prior prior RB cord-010119-t1x9gknd 1413 2 to to IN cord-010119-t1x9gknd 1413 3 the the DT cord-010119-t1x9gknd 1413 4 implementation implementation NN cord-010119-t1x9gknd 1413 5 of of IN cord-010119-t1x9gknd 1413 6 the the DT cord-010119-t1x9gknd 1413 7 FDA FDA NNP cord-010119-t1x9gknd 1413 8 's 's POS cord-010119-t1x9gknd 1413 9 Final Final NNP cord-010119-t1x9gknd 1413 10 Rule Rule NNP cord-010119-t1x9gknd 1413 11 , , , cord-010119-t1x9gknd 1413 12 blood blood NN cord-010119-t1x9gknd 1413 13 centers center NNS cord-010119-t1x9gknd 1413 14 asked ask VBD cord-010119-t1x9gknd 1413 15 donors donor NNS cord-010119-t1x9gknd 1413 16 for for IN cord-010119-t1x9gknd 1413 17 their -PRON- PRP$ cord-010119-t1x9gknd 1413 18 birth birth NN cord-010119-t1x9gknd 1413 19 gender gender NN cord-010119-t1x9gknd 1413 20 and and CC cord-010119-t1x9gknd 1413 21 determined determine VBD cord-010119-t1x9gknd 1413 22 eligibility eligibility NN cord-010119-t1x9gknd 1413 23 based base VBN cord-010119-t1x9gknd 1413 24 on on IN cord-010119-t1x9gknd 1413 25 that that DT cord-010119-t1x9gknd 1413 26 gender gender NN cord-010119-t1x9gknd 1413 27 . . . cord-010119-t1x9gknd 1414 1 If if IN cord-010119-t1x9gknd 1414 2 the the DT cord-010119-t1x9gknd 1414 3 donor donor NN cord-010119-t1x9gknd 1414 4 changed change VBD cord-010119-t1x9gknd 1414 5 their -PRON- PRP$ cord-010119-t1x9gknd 1414 6 gender gender NN cord-010119-t1x9gknd 1414 7 they -PRON- PRP cord-010119-t1x9gknd 1414 8 were be VBD cord-010119-t1x9gknd 1414 9 asked ask VBN cord-010119-t1x9gknd 1414 10 to to TO cord-010119-t1x9gknd 1414 11 answer answer VB cord-010119-t1x9gknd 1414 12 both both CC cord-010119-t1x9gknd 1414 13 the the DT cord-010119-t1x9gknd 1414 14 male male JJ cord-010119-t1x9gknd 1414 15 and and CC cord-010119-t1x9gknd 1414 16 female female JJ cord-010119-t1x9gknd 1414 17 questions question NNS cord-010119-t1x9gknd 1414 18 . . . cord-010119-t1x9gknd 1415 1 The the DT cord-010119-t1x9gknd 1415 2 Final Final NNP cord-010119-t1x9gknd 1415 3 Rule Rule NNP cord-010119-t1x9gknd 1415 4 now now RB cord-010119-t1x9gknd 1415 5 allows allow VBZ cord-010119-t1x9gknd 1415 6 blood blood NN cord-010119-t1x9gknd 1415 7 centers center NNS cord-010119-t1x9gknd 1415 8 to to TO cord-010119-t1x9gknd 1415 9 accept accept VB cord-010119-t1x9gknd 1415 10 the the DT cord-010119-t1x9gknd 1415 11 donor donor NN cord-010119-t1x9gknd 1415 12 's 's POS cord-010119-t1x9gknd 1415 13 stated state VBN cord-010119-t1x9gknd 1415 14 gender gender NN cord-010119-t1x9gknd 1415 15 and and CC cord-010119-t1x9gknd 1415 16 to to TO cord-010119-t1x9gknd 1415 17 determine determine VB cord-010119-t1x9gknd 1415 18 eligibility eligibility NN cord-010119-t1x9gknd 1415 19 based base VBN cord-010119-t1x9gknd 1415 20 on on IN cord-010119-t1x9gknd 1415 21 that that DT cord-010119-t1x9gknd 1415 22 gender gender NN cord-010119-t1x9gknd 1415 23 . . . cord-010119-t1x9gknd 1416 1 In in IN cord-010119-t1x9gknd 1416 2 order order NN cord-010119-t1x9gknd 1416 3 to to TO cord-010119-t1x9gknd 1416 4 assess assess VB cord-010119-t1x9gknd 1416 5 the the DT cord-010119-t1x9gknd 1416 6 risk risk NN cord-010119-t1x9gknd 1416 7 of of IN cord-010119-t1x9gknd 1416 8 failing fail VBG cord-010119-t1x9gknd 1416 9 to to TO cord-010119-t1x9gknd 1416 10 ask ask VB cord-010119-t1x9gknd 1416 11 a a DT cord-010119-t1x9gknd 1416 12 transgender transgender NN cord-010119-t1x9gknd 1416 13 male male JJ cord-010119-t1x9gknd 1416 14 donor donor NN cord-010119-t1x9gknd 1416 15 ( ( -LRB- cord-010119-t1x9gknd 1416 16 birth birth NN cord-010119-t1x9gknd 1416 17 gender gender NN cord-010119-t1x9gknd 1416 18 female female NN cord-010119-t1x9gknd 1416 19 ) ) -RRB- cord-010119-t1x9gknd 1417 1 the the DT cord-010119-t1x9gknd 1417 2 pregnancy pregnancy NN cord-010119-t1x9gknd 1417 3 question question NN cord-010119-t1x9gknd 1417 4 , , , cord-010119-t1x9gknd 1417 5 a a DT cord-010119-t1x9gknd 1417 6 review review NN cord-010119-t1x9gknd 1417 7 was be VBD cord-010119-t1x9gknd 1417 8 done do VBN cord-010119-t1x9gknd 1417 9 to to TO cord-010119-t1x9gknd 1417 10 determine determine VB cord-010119-t1x9gknd 1417 11 the the DT cord-010119-t1x9gknd 1417 12 number number NN cord-010119-t1x9gknd 1417 13 of of IN cord-010119-t1x9gknd 1417 14 transgender transgender NN cord-010119-t1x9gknd 1417 15 males male NNS cord-010119-t1x9gknd 1417 16 who who WP cord-010119-t1x9gknd 1417 17 were be VBD cord-010119-t1x9gknd 1417 18 actively actively RB cord-010119-t1x9gknd 1417 19 donating donate VBG cord-010119-t1x9gknd 1417 20 with with IN cord-010119-t1x9gknd 1417 21 a a DT cord-010119-t1x9gknd 1417 22 large large JJ cord-010119-t1x9gknd 1417 23 blood blood NN cord-010119-t1x9gknd 1417 24 center center NN cord-010119-t1x9gknd 1417 25 . . . cord-010119-t1x9gknd 1418 1 and and CC cord-010119-t1x9gknd 1418 2 tracked track VBN cord-010119-t1x9gknd 1418 3 . . . cord-010119-t1x9gknd 1419 1 Donors donor NNS cord-010119-t1x9gknd 1419 2 were be VBD cord-010119-t1x9gknd 1419 3 contacted contact VBN cord-010119-t1x9gknd 1419 4 to to TO cord-010119-t1x9gknd 1419 5 resolve resolve VB cord-010119-t1x9gknd 1419 6 any any DT cord-010119-t1x9gknd 1419 7 descrepancies descrepancie NNS cord-010119-t1x9gknd 1419 8 . . . cord-010119-t1x9gknd 1420 1 Donors donor NNS cord-010119-t1x9gknd 1420 2 who who WP cord-010119-t1x9gknd 1420 3 had have VBD cord-010119-t1x9gknd 1420 4 changed change VBN cord-010119-t1x9gknd 1420 5 their -PRON- PRP$ cord-010119-t1x9gknd 1420 6 gender gender NN cord-010119-t1x9gknd 1420 7 from from IN cord-010119-t1x9gknd 1420 8 female female JJ cord-010119-t1x9gknd 1420 9 to to IN cord-010119-t1x9gknd 1420 10 male male NN cord-010119-t1x9gknd 1420 11 and and CC cord-010119-t1x9gknd 1420 12 who who WP cord-010119-t1x9gknd 1420 13 had have VBD cord-010119-t1x9gknd 1420 14 answered answer VBN cord-010119-t1x9gknd 1420 15 yes yes UH cord-010119-t1x9gknd 1420 16 to to IN cord-010119-t1x9gknd 1420 17 prior prior JJ cord-010119-t1x9gknd 1420 18 pregnancies pregnancy NNS cord-010119-t1x9gknd 1420 19 were be VBD cord-010119-t1x9gknd 1420 20 identified identify VBN cord-010119-t1x9gknd 1420 21 . . . cord-010119-t1x9gknd 1421 1 HLA HLA NNP cord-010119-t1x9gknd 1421 2 antibody antibody NN cord-010119-t1x9gknd 1421 3 test test NN cord-010119-t1x9gknd 1421 4 results result NNS cord-010119-t1x9gknd 1421 5 were be VBD cord-010119-t1x9gknd 1421 6 reviewed review VBN cord-010119-t1x9gknd 1421 7 for for IN cord-010119-t1x9gknd 1421 8 these these DT cord-010119-t1x9gknd 1421 9 donors donor NNS cord-010119-t1x9gknd 1421 10 to to TO cord-010119-t1x9gknd 1421 11 see see VB cord-010119-t1x9gknd 1421 12 if if IN cord-010119-t1x9gknd 1421 13 they -PRON- PRP cord-010119-t1x9gknd 1421 14 had have VBD cord-010119-t1x9gknd 1421 15 been be VBN cord-010119-t1x9gknd 1421 16 tested test VBN cord-010119-t1x9gknd 1421 17 and and CC cord-010119-t1x9gknd 1421 18 whether whether IN cord-010119-t1x9gknd 1421 19 they -PRON- PRP cord-010119-t1x9gknd 1421 20 had have VBD cord-010119-t1x9gknd 1421 21 tested test VBN cord-010119-t1x9gknd 1421 22 positive positive JJ cord-010119-t1x9gknd 1421 23 or or CC cord-010119-t1x9gknd 1421 24 negative negative JJ cord-010119-t1x9gknd 1421 25 . . . cord-010119-t1x9gknd 1422 1 Results/ Results/ . cord-010119-t1x9gknd 1423 1 Finding finding NN cord-010119-t1x9gknd 1423 2 : : : cord-010119-t1x9gknd 1424 1 From from IN cord-010119-t1x9gknd 1424 2 2013 2013 CD cord-010119-t1x9gknd 1424 3 -2015 -2015 NNS cord-010119-t1x9gknd 1424 4 , , , cord-010119-t1x9gknd 1424 5 there there EX cord-010119-t1x9gknd 1424 6 were be VBD cord-010119-t1x9gknd 1424 7 181 181 CD cord-010119-t1x9gknd 1424 8 donors donor NNS cord-010119-t1x9gknd 1424 9 identified identify VBN cord-010119-t1x9gknd 1424 10 who who WP cord-010119-t1x9gknd 1424 11 had have VBD cord-010119-t1x9gknd 1424 12 changed change VBN cord-010119-t1x9gknd 1424 13 their -PRON- PRP$ cord-010119-t1x9gknd 1424 14 gender gender NN cord-010119-t1x9gknd 1424 15 from from IN cord-010119-t1x9gknd 1424 16 their -PRON- PRP$ cord-010119-t1x9gknd 1424 17 birth birth NN cord-010119-t1x9gknd 1424 18 gender gender NN cord-010119-t1x9gknd 1424 19 ; ; : cord-010119-t1x9gknd 1424 20 121 121 CD cord-010119-t1x9gknd 1424 21 female female JJ cord-010119-t1x9gknd 1424 22 donors donor NNS cord-010119-t1x9gknd 1424 23 changed change VBD cord-010119-t1x9gknd 1424 24 their -PRON- PRP$ cord-010119-t1x9gknd 1424 25 gender gender NN cord-010119-t1x9gknd 1424 26 to to IN cord-010119-t1x9gknd 1424 27 male male JJ cord-010119-t1x9gknd 1424 28 and and CC cord-010119-t1x9gknd 1424 29 60 60 CD cord-010119-t1x9gknd 1424 30 male male JJ cord-010119-t1x9gknd 1424 31 donors donor NNS cord-010119-t1x9gknd 1424 32 changed change VBD cord-010119-t1x9gknd 1424 33 their -PRON- PRP$ cord-010119-t1x9gknd 1424 34 gender gender NN cord-010119-t1x9gknd 1424 35 to to IN cord-010119-t1x9gknd 1424 36 female female JJ cord-010119-t1x9gknd 1424 37 . . . cord-010119-t1x9gknd 1425 1 There there EX cord-010119-t1x9gknd 1425 2 were be VBD cord-010119-t1x9gknd 1425 3 7 7 CD cord-010119-t1x9gknd 1425 4 ( ( -LRB- cord-010119-t1x9gknd 1425 5 6 6 CD cord-010119-t1x9gknd 1425 6 % % NN cord-010119-t1x9gknd 1425 7 ) ) -RRB- cord-010119-t1x9gknd 1426 1 transgender transgender NNP cord-010119-t1x9gknd 1426 2 male male JJ cord-010119-t1x9gknd 1426 3 donors donor NNS cord-010119-t1x9gknd 1426 4 , , , cord-010119-t1x9gknd 1426 5 birth birth NN cord-010119-t1x9gknd 1426 6 gender gender NN cord-010119-t1x9gknd 1426 7 female female NN cord-010119-t1x9gknd 1426 8 , , , cord-010119-t1x9gknd 1426 9 who who WP cord-010119-t1x9gknd 1426 10 had have VBD cord-010119-t1x9gknd 1426 11 answered answer VBN cord-010119-t1x9gknd 1426 12 yes yes UH cord-010119-t1x9gknd 1426 13 to to IN cord-010119-t1x9gknd 1426 14 the the DT cord-010119-t1x9gknd 1426 15 pregnancy pregnancy NN cord-010119-t1x9gknd 1426 16 question question NN cord-010119-t1x9gknd 1426 17 at at IN cord-010119-t1x9gknd 1426 18 one one CD cord-010119-t1x9gknd 1426 19 of of IN cord-010119-t1x9gknd 1426 20 their -PRON- PRP$ cord-010119-t1x9gknd 1426 21 donations donation NNS cord-010119-t1x9gknd 1426 22 . . . cord-010119-t1x9gknd 1427 1 Three three CD cord-010119-t1x9gknd 1427 2 of of IN cord-010119-t1x9gknd 1427 3 these these DT cord-010119-t1x9gknd 1427 4 donors donor NNS cord-010119-t1x9gknd 1427 5 were be VBD cord-010119-t1x9gknd 1427 6 apheresis apheresis NN cord-010119-t1x9gknd 1427 7 donors donor NNS cord-010119-t1x9gknd 1427 8 who who WP cord-010119-t1x9gknd 1427 9 had have VBD cord-010119-t1x9gknd 1427 10 been be VBN cord-010119-t1x9gknd 1427 11 tested test VBN cord-010119-t1x9gknd 1427 12 for for IN cord-010119-t1x9gknd 1427 13 HLA HLA NNP cord-010119-t1x9gknd 1427 14 antibodies antibody NNS cord-010119-t1x9gknd 1427 15 . . . cord-010119-t1x9gknd 1428 1 One one CD cord-010119-t1x9gknd 1428 2 tested test VBD cord-010119-t1x9gknd 1428 3 positive positive JJ cord-010119-t1x9gknd 1428 4 and and CC cord-010119-t1x9gknd 1428 5 the the DT cord-010119-t1x9gknd 1428 6 other other JJ cord-010119-t1x9gknd 1428 7 two two CD cord-010119-t1x9gknd 1428 8 tested test VBN cord-010119-t1x9gknd 1428 9 negative negative JJ cord-010119-t1x9gknd 1428 10 for for IN cord-010119-t1x9gknd 1428 11 HLA HLA NNP cord-010119-t1x9gknd 1428 12 antibodies antibody NNS cord-010119-t1x9gknd 1428 13 . . . cord-010119-t1x9gknd 1429 1 The the DT cord-010119-t1x9gknd 1429 2 four four CD cord-010119-t1x9gknd 1429 3 other other JJ cord-010119-t1x9gknd 1429 4 donors donor NNS cord-010119-t1x9gknd 1429 5 were be VBD cord-010119-t1x9gknd 1429 6 whole whole JJ cord-010119-t1x9gknd 1429 7 blood blood NN cord-010119-t1x9gknd 1429 8 donors donor NNS cord-010119-t1x9gknd 1429 9 and and CC cord-010119-t1x9gknd 1429 10 had have VBD cord-010119-t1x9gknd 1429 11 not not RB cord-010119-t1x9gknd 1429 12 been be VBN cord-010119-t1x9gknd 1429 13 tested test VBN cord-010119-t1x9gknd 1429 14 . . . cord-010119-t1x9gknd 1430 1 An an DT cord-010119-t1x9gknd 1430 2 HLA HLA NNP cord-010119-t1x9gknd 1430 3 test test NN cord-010119-t1x9gknd 1430 4 was be VBD cord-010119-t1x9gknd 1430 5 added add VBN cord-010119-t1x9gknd 1430 6 to to IN cord-010119-t1x9gknd 1430 7 these these DT cord-010119-t1x9gknd 1430 8 donors donor NNS cord-010119-t1x9gknd 1430 9 ' ' POS cord-010119-t1x9gknd 1430 10 records record NNS cord-010119-t1x9gknd 1430 11 so so IN cord-010119-t1x9gknd 1430 12 that that IN cord-010119-t1x9gknd 1430 13 the the DT cord-010119-t1x9gknd 1430 14 test test NN cord-010119-t1x9gknd 1430 15 could could MD cord-010119-t1x9gknd 1430 16 be be VB cord-010119-t1x9gknd 1430 17 performed perform VBN cord-010119-t1x9gknd 1430 18 the the DT cord-010119-t1x9gknd 1430 19 next next JJ cord-010119-t1x9gknd 1430 20 time time NN cord-010119-t1x9gknd 1430 21 they -PRON- PRP cord-010119-t1x9gknd 1430 22 presented present VBD cord-010119-t1x9gknd 1430 23 to to TO cord-010119-t1x9gknd 1430 24 donate donate VB cord-010119-t1x9gknd 1430 25 . . . cord-010119-t1x9gknd 1431 1 Conclusion conclusion NN cord-010119-t1x9gknd 1431 2 : : : cord-010119-t1x9gknd 1432 1 Transgender transgender JJ cord-010119-t1x9gknd 1432 2 male male JJ cord-010119-t1x9gknd 1432 3 donors donor NNS cord-010119-t1x9gknd 1432 4 may may MD cord-010119-t1x9gknd 1432 5 have have VB cord-010119-t1x9gknd 1432 6 had have VBN cord-010119-t1x9gknd 1432 7 prior prior JJ cord-010119-t1x9gknd 1432 8 pregnancies pregnancy NNS cord-010119-t1x9gknd 1432 9 and and CC cord-010119-t1x9gknd 1432 10 are be VBP cord-010119-t1x9gknd 1432 11 also also RB cord-010119-t1x9gknd 1432 12 choosing choose VBG cord-010119-t1x9gknd 1432 13 to to TO cord-010119-t1x9gknd 1432 14 become become VB cord-010119-t1x9gknd 1432 15 pregnant pregnant JJ cord-010119-t1x9gknd 1432 16 after after IN cord-010119-t1x9gknd 1432 17 having have VBG cord-010119-t1x9gknd 1432 18 transitioned transition VBN cord-010119-t1x9gknd 1432 19 from from IN cord-010119-t1x9gknd 1432 20 female female JJ cord-010119-t1x9gknd 1432 21 to to IN cord-010119-t1x9gknd 1432 22 male male NN cord-010119-t1x9gknd 1432 23 . . . cord-010119-t1x9gknd 1433 1 Six six CD cord-010119-t1x9gknd 1433 2 percent percent NN cord-010119-t1x9gknd 1433 3 of of IN cord-010119-t1x9gknd 1433 4 transgender transgender NN cord-010119-t1x9gknd 1433 5 males male NNS cord-010119-t1x9gknd 1433 6 that that WDT cord-010119-t1x9gknd 1433 7 we -PRON- PRP cord-010119-t1x9gknd 1433 8 identified identify VBD cord-010119-t1x9gknd 1433 9 reported report VBD cord-010119-t1x9gknd 1433 10 a a DT cord-010119-t1x9gknd 1433 11 prior prior JJ cord-010119-t1x9gknd 1433 12 history history NN cord-010119-t1x9gknd 1433 13 of of IN cord-010119-t1x9gknd 1433 14 pregnancy pregnancy NN cord-010119-t1x9gknd 1433 15 . . . cord-010119-t1x9gknd 1434 1 At at IN cord-010119-t1x9gknd 1434 2 our -PRON- PRP$ cord-010119-t1x9gknd 1434 3 center center NN cord-010119-t1x9gknd 1434 4 , , , cord-010119-t1x9gknd 1434 5 when when WRB cord-010119-t1x9gknd 1434 6 a a DT cord-010119-t1x9gknd 1434 7 donor donor NN cord-010119-t1x9gknd 1434 8 requests request VBZ cord-010119-t1x9gknd 1434 9 a a DT cord-010119-t1x9gknd 1434 10 gender gender NN cord-010119-t1x9gknd 1434 11 change change NN cord-010119-t1x9gknd 1434 12 from from IN cord-010119-t1x9gknd 1434 13 female female JJ cord-010119-t1x9gknd 1434 14 to to IN cord-010119-t1x9gknd 1434 15 male male NN cord-010119-t1x9gknd 1434 16 , , , cord-010119-t1x9gknd 1434 17 an an DT cord-010119-t1x9gknd 1434 18 HLA HLA NNP cord-010119-t1x9gknd 1434 19 test test NN cord-010119-t1x9gknd 1434 20 is be VBZ cord-010119-t1x9gknd 1434 21 requested request VBN cord-010119-t1x9gknd 1434 22 for for IN cord-010119-t1x9gknd 1434 23 the the DT cord-010119-t1x9gknd 1434 24 next next JJ cord-010119-t1x9gknd 1434 25 donation donation NN cord-010119-t1x9gknd 1434 26 . . . cord-010119-t1x9gknd 1435 1 First first JJ cord-010119-t1x9gknd 1435 2 time time NN cord-010119-t1x9gknd 1435 3 donors donor NNS cord-010119-t1x9gknd 1435 4 are be VBP cord-010119-t1x9gknd 1435 5 qualified qualified JJ cord-010119-t1x9gknd 1435 6 based base VBN cord-010119-t1x9gknd 1435 7 on on IN cord-010119-t1x9gknd 1435 8 their -PRON- PRP$ cord-010119-t1x9gknd 1435 9 stated state VBN cord-010119-t1x9gknd 1435 10 gender gender NN cord-010119-t1x9gknd 1435 11 so so RB cord-010119-t1x9gknd 1435 12 transgender transgender NN cord-010119-t1x9gknd 1435 13 donors donor NNS cord-010119-t1x9gknd 1435 14 with with IN cord-010119-t1x9gknd 1435 15 a a DT cord-010119-t1x9gknd 1435 16 history history NN cord-010119-t1x9gknd 1435 17 of of IN cord-010119-t1x9gknd 1435 18 pregnancy pregnancy NN cord-010119-t1x9gknd 1435 19 will will MD cord-010119-t1x9gknd 1435 20 not not RB cord-010119-t1x9gknd 1435 21 be be VB cord-010119-t1x9gknd 1435 22 identified identify VBN cord-010119-t1x9gknd 1435 23 unless unless IN cord-010119-t1x9gknd 1435 24 they -PRON- PRP cord-010119-t1x9gknd 1435 25 volunteer volunteer VBP cord-010119-t1x9gknd 1435 26 this this DT cord-010119-t1x9gknd 1435 27 information information NN cord-010119-t1x9gknd 1435 28 . . . cord-010119-t1x9gknd 1436 1 Consideration consideration NN cord-010119-t1x9gknd 1436 2 should should MD cord-010119-t1x9gknd 1436 3 be be VB cord-010119-t1x9gknd 1436 4 given give VBN cord-010119-t1x9gknd 1436 5 to to IN cord-010119-t1x9gknd 1436 6 using use VBG cord-010119-t1x9gknd 1436 7 educational educational JJ cord-010119-t1x9gknd 1436 8 materials material NNS cord-010119-t1x9gknd 1436 9 to to TO cord-010119-t1x9gknd 1436 10 prompt prompt VB cord-010119-t1x9gknd 1436 11 the the DT cord-010119-t1x9gknd 1436 12 donor donor NN cord-010119-t1x9gknd 1436 13 to to TO cord-010119-t1x9gknd 1436 14 reveal reveal VB cord-010119-t1x9gknd 1436 15 a a DT cord-010119-t1x9gknd 1436 16 history history NN cord-010119-t1x9gknd 1436 17 of of IN cord-010119-t1x9gknd 1436 18 pregnancy pregnancy NN cord-010119-t1x9gknd 1436 19 at at IN cord-010119-t1x9gknd 1436 20 the the DT cord-010119-t1x9gknd 1436 21 time time NN cord-010119-t1x9gknd 1436 22 of of IN cord-010119-t1x9gknd 1436 23 donation donation NN cord-010119-t1x9gknd 1436 24 so so IN cord-010119-t1x9gknd 1436 25 that that IN cord-010119-t1x9gknd 1436 26 HLA HLA NNP cord-010119-t1x9gknd 1436 27 antibody antibody NN cord-010119-t1x9gknd 1436 28 testing testing NN cord-010119-t1x9gknd 1436 29 can can MD cord-010119-t1x9gknd 1436 30 be be VB cord-010119-t1x9gknd 1436 31 performed perform VBN cord-010119-t1x9gknd 1436 32 . . . cord-010119-t1x9gknd 1437 1 Effect effect NN cord-010119-t1x9gknd 1437 2 of of IN cord-010119-t1x9gknd 1437 3 Variable variable JJ cord-010119-t1x9gknd 1437 4 Volume volume NN cord-010119-t1x9gknd 1437 5 Scale scale NN cord-010119-t1x9gknd 1437 6 Introduction introduction NN cord-010119-t1x9gknd 1437 7 in in IN cord-010119-t1x9gknd 1437 8 a a DT cord-010119-t1x9gknd 1437 9 Large large JJ cord-010119-t1x9gknd 1437 10 Multi multi JJ cord-010119-t1x9gknd 1437 11 - - HYPH cord-010119-t1x9gknd 1437 12 Site Site NNP cord-010119-t1x9gknd 1437 13 Blood Blood NNP cord-010119-t1x9gknd 1437 14 Center Center NNP cord-010119-t1x9gknd 1437 15 Ralph Ralph NNP cord-010119-t1x9gknd 1437 16 R R NNP cord-010119-t1x9gknd 1437 17 Vassallo Vassallo NNP cord-010119-t1x9gknd 1437 18 * * NFP cord-010119-t1x9gknd 1437 19 , , , cord-010119-t1x9gknd 1437 20 Marjorie Marjorie NNP cord-010119-t1x9gknd 1437 21 D D NNP cord-010119-t1x9gknd 1437 22 Bravo Bravo NNP cord-010119-t1x9gknd 1437 23 and and CC cord-010119-t1x9gknd 1437 24 Hany Hany NNP cord-010119-t1x9gknd 1437 25 Kamel Kamel NNP cord-010119-t1x9gknd 1437 26 . . . cord-010119-t1x9gknd 1438 1 Blood blood NN cord-010119-t1x9gknd 1438 2 Systems Systems NNPS cord-010119-t1x9gknd 1438 3 , , , cord-010119-t1x9gknd 1439 1 Inc. Inc. NNP cord-010119-t1x9gknd 1439 2 Background Background NNP cord-010119-t1x9gknd 1439 3 / / SYM cord-010119-t1x9gknd 1439 4 Case Case NNP cord-010119-t1x9gknd 1439 5 Studies Studies NNPS cord-010119-t1x9gknd 1439 6 : : : cord-010119-t1x9gknd 1440 1 Regulations regulation NNS cord-010119-t1x9gknd 1440 2 allow allow VBP cord-010119-t1x9gknd 1440 3 whole whole JJ cord-010119-t1x9gknd 1440 4 blood blood NN cord-010119-t1x9gknd 1440 5 donation donation NN cord-010119-t1x9gknd 1440 6 [ [ -LRB- cord-010119-t1x9gknd 1440 7 WBD WBD NNP cord-010119-t1x9gknd 1440 8 ] ] -RRB- cord-010119-t1x9gknd 1440 9 of of IN cord-010119-t1x9gknd 1440 10 up up IN cord-010119-t1x9gknd 1440 11 to to TO cord-010119-t1x9gknd 1440 12 10.5 10.5 CD cord-010119-t1x9gknd 1440 13 mL ml NN cord-010119-t1x9gknd 1440 14 / / SYM cord-010119-t1x9gknd 1440 15 kg kg NNS cord-010119-t1x9gknd 1440 16 or or CC cord-010119-t1x9gknd 1440 17 15 15 CD cord-010119-t1x9gknd 1440 18 % % NN cord-010119-t1x9gknd 1440 19 of of IN cord-010119-t1x9gknd 1440 20 estimated estimate VBN cord-010119-t1x9gknd 1440 21 blood blood NN cord-010119-t1x9gknd 1440 22 volume volume NN cord-010119-t1x9gknd 1440 23 [ [ -LRB- cord-010119-t1x9gknd 1440 24 EBV EBV NNP cord-010119-t1x9gknd 1440 25 ] ] -RRB- cord-010119-t1x9gknd 1440 26 . . . cord-010119-t1x9gknd 1441 1 Traditional traditional JJ cord-010119-t1x9gknd 1441 2 measuring measuring NN cord-010119-t1x9gknd 1441 3 / / SYM cord-010119-t1x9gknd 1441 4 mixing mix VBG cord-010119-t1x9gknd 1441 5 devices device NNS cord-010119-t1x9gknd 1441 6 are be VBP cord-010119-t1x9gknd 1441 7 set set VBN cord-010119-t1x9gknd 1441 8 to to TO cord-010119-t1x9gknd 1441 9 halt halt VB cord-010119-t1x9gknd 1441 10 blood blood NN cord-010119-t1x9gknd 1441 11 flow flow NN cord-010119-t1x9gknd 1441 12 at at IN cord-010119-t1x9gknd 1441 13 fixed fix VBN cord-010119-t1x9gknd 1441 14 volumes volume NNS cord-010119-t1x9gknd 1441 15 which which WDT cord-010119-t1x9gknd 1441 16 , , , cord-010119-t1x9gknd 1441 17 with with IN cord-010119-t1x9gknd 1441 18 testing testing NN cord-010119-t1x9gknd 1441 19 samples sample NNS cord-010119-t1x9gknd 1441 20 , , , cord-010119-t1x9gknd 1441 21 are be VBP cord-010119-t1x9gknd 1441 22 consistently consistently RB cord-010119-t1x9gknd 1441 23 below below IN cord-010119-t1x9gknd 1441 24 the the DT cord-010119-t1x9gknd 1441 25 15 15 CD cord-010119-t1x9gknd 1441 26 % % NN cord-010119-t1x9gknd 1441 27 limit limit NN cord-010119-t1x9gknd 1441 28 . . . cord-010119-t1x9gknd 1442 1 Variable variable JJ cord-010119-t1x9gknd 1442 2 volume volume NN cord-010119-t1x9gknd 1442 3 scales scale NNS cord-010119-t1x9gknd 1442 4 [ [ -LRB- cord-010119-t1x9gknd 1442 5 VVS VVS NNP cord-010119-t1x9gknd 1442 6 ] ] -RRB- cord-010119-t1x9gknd 1442 7 can can MD cord-010119-t1x9gknd 1442 8 be be VB cord-010119-t1x9gknd 1442 9 programmed program VBN cord-010119-t1x9gknd 1442 10 to to TO cord-010119-t1x9gknd 1442 11 vary vary VB cord-010119-t1x9gknd 1442 12 unit unit NN cord-010119-t1x9gknd 1442 13 volume volume NN cord-010119-t1x9gknd 1442 14 ( ( -LRB- cord-010119-t1x9gknd 1442 15 up up IN cord-010119-t1x9gknd 1442 16 to to TO cord-010119-t1x9gknd 1442 17 550 550 CD cord-010119-t1x9gknd 1442 18 mL ml NN cord-010119-t1x9gknd 1442 19 ) ) -RRB- cord-010119-t1x9gknd 1442 20 by by IN cord-010119-t1x9gknd 1442 21 donor donor NN cord-010119-t1x9gknd 1442 22 EBV EBV NNP cord-010119-t1x9gknd 1442 23 . . . cord-010119-t1x9gknd 1443 1 This this DT cord-010119-t1x9gknd 1443 2 maximizes maximize VBZ cord-010119-t1x9gknd 1443 3 transfusable transfusable JJ cord-010119-t1x9gknd 1443 4 RBCs rbc NNS cord-010119-t1x9gknd 1443 5 and and CC cord-010119-t1x9gknd 1443 6 plasma plasma NN cord-010119-t1x9gknd 1443 7 and and CC cord-010119-t1x9gknd 1443 8 recovered recover VBD cord-010119-t1x9gknd 1443 9 plasma plasma NN cord-010119-t1x9gknd 1443 10 [ [ -LRB- cord-010119-t1x9gknd 1443 11 RP rp NN cord-010119-t1x9gknd 1443 12 ] ] -RRB- cord-010119-t1x9gknd 1443 13 volume volume NN cord-010119-t1x9gknd 1443 14 . . . cord-010119-t1x9gknd 1444 1 RP RP NNP cord-010119-t1x9gknd 1444 2 from from IN cord-010119-t1x9gknd 1444 3 WBDs wbd NNS cord-010119-t1x9gknd 1444 4 is be VBZ cord-010119-t1x9gknd 1444 5 a a DT cord-010119-t1x9gknd 1444 6 small small JJ cord-010119-t1x9gknd 1444 7 but but CC cord-010119-t1x9gknd 1444 8 important important JJ cord-010119-t1x9gknd 1444 9 source source NN cord-010119-t1x9gknd 1444 10 of of IN cord-010119-t1x9gknd 1444 11 derivatives derivative NNS cord-010119-t1x9gknd 1444 12 and and CC cord-010119-t1x9gknd 1444 13 blood blood NN cord-010119-t1x9gknd 1444 14 center center NN cord-010119-t1x9gknd 1444 15 cost cost NN cord-010119-t1x9gknd 1444 16 recovery recovery NN cord-010119-t1x9gknd 1444 17 . . . cord-010119-t1x9gknd 1445 1 We -PRON- PRP cord-010119-t1x9gknd 1445 2 report report VBP cord-010119-t1x9gknd 1445 3 the the DT cord-010119-t1x9gknd 1445 4 effect effect NN cord-010119-t1x9gknd 1445 5 of of IN cord-010119-t1x9gknd 1445 6 introducing introduce VBG cord-010119-t1x9gknd 1445 7 the the DT cord-010119-t1x9gknd 1445 8 Hemoflow Hemoflow NNP cord-010119-t1x9gknd 1445 9 VVS vvs NN cord-010119-t1x9gknd 1445 10 on on IN cord-010119-t1x9gknd 1445 11 donor donor NN cord-010119-t1x9gknd 1445 12 reaction reaction NN cord-010119-t1x9gknd 1445 13 rates rate NNS cord-010119-t1x9gknd 1445 14 and and CC cord-010119-t1x9gknd 1445 15 RP rp NN cord-010119-t1x9gknd 1445 16 volume volume NN cord-010119-t1x9gknd 1445 17 in in IN cord-010119-t1x9gknd 1445 18 a a DT cord-010119-t1x9gknd 1445 19 large large JJ cord-010119-t1x9gknd 1445 20 blood blood NN cord-010119-t1x9gknd 1445 21 center center NN cord-010119-t1x9gknd 1445 22 . . . cord-010119-t1x9gknd 1446 1 Compared compare VBN cord-010119-t1x9gknd 1446 2 to to IN cord-010119-t1x9gknd 1446 3 previous previous JJ cord-010119-t1x9gknd 1446 4 fixed fix VBN cord-010119-t1x9gknd 1446 5 settings setting NNS cord-010119-t1x9gknd 1446 6 , , , cord-010119-t1x9gknd 1446 7 variable variable JJ cord-010119-t1x9gknd 1446 8 collection collection NN cord-010119-t1x9gknd 1446 9 volumes volume NNS cord-010119-t1x9gknd 1446 10 were be VBD cord-010119-t1x9gknd 1446 11 expected expect VBN cord-010119-t1x9gknd 1446 12 to to TO cord-010119-t1x9gknd 1446 13 decrease decrease VB cord-010119-t1x9gknd 1446 14 by by IN cord-010119-t1x9gknd 1446 15 10 10 CD cord-010119-t1x9gknd 1446 16 mL ml NN cord-010119-t1x9gknd 1446 17 at at IN cord-010119-t1x9gknd 1446 18 EBVs ebv NNS cord-010119-t1x9gknd 1446 19 < < XX cord-010119-t1x9gknd 1446 20 3.5L 3.5L NNS cord-010119-t1x9gknd 1446 21 in in IN cord-010119-t1x9gknd 1446 22 donors donor NNS cord-010119-t1x9gknd 1446 23 ! ! . cord-010119-t1x9gknd 1447 1 23 23 CD cord-010119-t1x9gknd 1447 2 yo yo UH cord-010119-t1x9gknd 1447 3 , , , cord-010119-t1x9gknd 1447 4 but but CC cord-010119-t1x9gknd 1447 5 increase increase VB cord-010119-t1x9gknd 1447 6 by by IN cord-010119-t1x9gknd 1447 7 5 5 CD cord-010119-t1x9gknd 1447 8 - - SYM cord-010119-t1x9gknd 1447 9 40 40 CD cord-010119-t1x9gknd 1447 10 mL ml NN cord-010119-t1x9gknd 1447 11 for for IN cord-010119-t1x9gknd 1447 12 all all DT cord-010119-t1x9gknd 1447 13 others other NNS cord-010119-t1x9gknd 1447 14 . . . cord-010119-t1x9gknd 1448 1 Study Study NNP cord-010119-t1x9gknd 1448 2 Design Design NNP cord-010119-t1x9gknd 1448 3 / / SYM cord-010119-t1x9gknd 1448 4 Method method NN cord-010119-t1x9gknd 1448 5 : : : cord-010119-t1x9gknd 1448 6 Donor donor NN cord-010119-t1x9gknd 1448 7 vasovagal vasovagal NN cord-010119-t1x9gknd 1448 8 reaction reaction NN cord-010119-t1x9gknd 1448 9 [ [ -LRB- cord-010119-t1x9gknd 1448 10 VVR vvr NN cord-010119-t1x9gknd 1448 11 ] ] -RRB- cord-010119-t1x9gknd 1448 12 rates rate NNS cord-010119-t1x9gknd 1448 13 ( ( -LRB- cord-010119-t1x9gknd 1448 14 prefaints prefaint NNS cord-010119-t1x9gknd 1448 15 , , , cord-010119-t1x9gknd 1448 16 prolonged prolonged JJ cord-010119-t1x9gknd 1448 17 / / SYM cord-010119-t1x9gknd 1448 18 offsite offsite JJ cord-010119-t1x9gknd 1448 19 reactions reaction NNS cord-010119-t1x9gknd 1448 20 , , , cord-010119-t1x9gknd 1448 21 and and CC cord-010119-t1x9gknd 1448 22 loss loss NN cord-010119-t1x9gknd 1448 23 of of IN cord-010119-t1x9gknd 1448 24 consciousness consciousness NN cord-010119-t1x9gknd 1448 25 [ [ -LRB- cord-010119-t1x9gknd 1448 26 LOC LOC NNP cord-010119-t1x9gknd 1448 27 ] ] -RRB- cord-010119-t1x9gknd 1448 28 ) ) -RRB- cord-010119-t1x9gknd 1448 29 for for IN cord-010119-t1x9gknd 1448 30 successful successful JJ cord-010119-t1x9gknd 1448 31 WBDs wbd NNS cord-010119-t1x9gknd 1448 32 were be VBD cord-010119-t1x9gknd 1448 33 obtained obtain VBN cord-010119-t1x9gknd 1448 34 from from IN cord-010119-t1x9gknd 1448 35 the the DT cord-010119-t1x9gknd 1448 36 center center NN cord-010119-t1x9gknd 1448 37 's 's POS cord-010119-t1x9gknd 1448 38 hemovigilance hemovigilance NN cord-010119-t1x9gknd 1448 39 database database NN cord-010119-t1x9gknd 1448 40 for for IN cord-010119-t1x9gknd 1448 41 the the DT cord-010119-t1x9gknd 1448 42 18 18 CD cord-010119-t1x9gknd 1448 43 mos mos NN cord-010119-t1x9gknd 1448 44 . . . cord-010119-t1x9gknd 1449 1 before before IN cord-010119-t1x9gknd 1449 2 a a DT cord-010119-t1x9gknd 1449 3 6 6 CD cord-010119-t1x9gknd 1449 4 mo mo NN cord-010119-t1x9gknd 1449 5 . . . cord-010119-t1x9gknd 1450 1 phased phase VBN cord-010119-t1x9gknd 1450 2 implementation implementation NN cord-010119-t1x9gknd 1450 3 of of IN cord-010119-t1x9gknd 1450 4 the the DT cord-010119-t1x9gknd 1450 5 VVS vvs NN cord-010119-t1x9gknd 1450 6 , , , cord-010119-t1x9gknd 1450 7 and and CC cord-010119-t1x9gknd 1450 8 the the DT cord-010119-t1x9gknd 1450 9 subsequent subsequent JJ cord-010119-t1x9gknd 1450 10 24 24 CD cord-010119-t1x9gknd 1450 11 mos mos NN cord-010119-t1x9gknd 1450 12 . . . cord-010119-t1x9gknd 1451 1 Multivariable multivariable JJ cord-010119-t1x9gknd 1451 2 analysis analysis NN cord-010119-t1x9gknd 1451 3 [ [ -LRB- cord-010119-t1x9gknd 1451 4 MVA MVA NNP cord-010119-t1x9gknd 1451 5 ] ] -RRB- cord-010119-t1x9gknd 1451 6 by by IN cord-010119-t1x9gknd 1451 7 6-mo 6-mo CD cord-010119-t1x9gknd 1451 8 . . . cord-010119-t1x9gknd 1452 1 periods period NNS cord-010119-t1x9gknd 1452 2 was be VBD cord-010119-t1x9gknd 1452 3 performed perform VBN cord-010119-t1x9gknd 1452 4 in in IN cord-010119-t1x9gknd 1452 5 a a DT cord-010119-t1x9gknd 1452 6 model model NN cord-010119-t1x9gknd 1452 7 incorporating incorporate VBG cord-010119-t1x9gknd 1452 8 donor donor NN cord-010119-t1x9gknd 1452 9 sex sex NN cord-010119-t1x9gknd 1452 10 , , , cord-010119-t1x9gknd 1452 11 age age NN cord-010119-t1x9gknd 1452 12 , , , cord-010119-t1x9gknd 1452 13 first first JJ cord-010119-t1x9gknd 1452 14 - - HYPH cord-010119-t1x9gknd 1452 15 time time NN cord-010119-t1x9gknd 1452 16 [ [ -LRB- cord-010119-t1x9gknd 1452 17 FTD FTD NNP cord-010119-t1x9gknd 1452 18 ] ] -RRB- cord-010119-t1x9gknd 1452 19 vs. vs. CC cord-010119-t1x9gknd 1452 20 repeat repeat NN cord-010119-t1x9gknd 1452 21 status status NN cord-010119-t1x9gknd 1452 22 , , , cord-010119-t1x9gknd 1452 23 EBV EBV NNP cord-010119-t1x9gknd 1452 24 and and CC cord-010119-t1x9gknd 1452 25 donation donation NN cord-010119-t1x9gknd 1452 26 site site NN cord-010119-t1x9gknd 1452 27 . . . cord-010119-t1x9gknd 1453 1 Both both DT cord-010119-t1x9gknd 1453 2 the the DT cord-010119-t1x9gknd 1453 3 volume volume NN cord-010119-t1x9gknd 1453 4 and and CC cord-010119-t1x9gknd 1453 5 number number NN cord-010119-t1x9gknd 1453 6 of of IN cord-010119-t1x9gknd 1453 7 units unit NNS cord-010119-t1x9gknd 1453 8 of of IN cord-010119-t1x9gknd 1453 9 plasma plasma NN cord-010119-t1x9gknd 1453 10 sent send VBN cord-010119-t1x9gknd 1453 11 for for IN cord-010119-t1x9gknd 1453 12 fractionation fractionation NN cord-010119-t1x9gknd 1453 13 were be VBD cord-010119-t1x9gknd 1453 14 available available JJ cord-010119-t1x9gknd 1453 15 for for IN cord-010119-t1x9gknd 1453 16 the the DT cord-010119-t1x9gknd 1453 17 same same JJ cord-010119-t1x9gknd 1453 18 time time NN cord-010119-t1x9gknd 1453 19 periods period NNS cord-010119-t1x9gknd 1453 20 from from IN cord-010119-t1x9gknd 1453 21 the the DT cord-010119-t1x9gknd 1453 22 blood blood NN cord-010119-t1x9gknd 1453 23 center center NN cord-010119-t1x9gknd 1453 24 's 's POS cord-010119-t1x9gknd 1453 25 data data NN cord-010119-t1x9gknd 1453 26 warehouse warehouse NN cord-010119-t1x9gknd 1453 27 . . . cord-010119-t1x9gknd 1454 1 Results result NNS cord-010119-t1x9gknd 1454 2 / / SYM cord-010119-t1x9gknd 1454 3 Finding finding NN cord-010119-t1x9gknd 1454 4 : : : cord-010119-t1x9gknd 1455 1 Compared compare VBN cord-010119-t1x9gknd 1455 2 to to IN cord-010119-t1x9gknd 1455 3 the the DT cord-010119-t1x9gknd 1455 4 baseline baseline JJ cord-010119-t1x9gknd 1455 5 period period NN cord-010119-t1x9gknd 1455 6 , , , cord-010119-t1x9gknd 1455 7 a a DT cord-010119-t1x9gknd 1455 8 significant significant JJ cord-010119-t1x9gknd 1455 9 increase increase NN cord-010119-t1x9gknd 1455 10 in in IN cord-010119-t1x9gknd 1455 11 prefaint prefaint NN cord-010119-t1x9gknd 1455 12 reaction reaction NN cord-010119-t1x9gknd 1455 13 rates rate NNS cord-010119-t1x9gknd 1455 14 were be VBD cord-010119-t1x9gknd 1455 15 noted note VBN cord-010119-t1x9gknd 1455 16 in in IN cord-010119-t1x9gknd 1455 17 Pre Pre NNP cord-010119-t1x9gknd 1455 18 - - NN cord-010119-t1x9gknd 1455 19 Implementation implementation NN cord-010119-t1x9gknd 1455 20 ( ( -LRB- cord-010119-t1x9gknd 1455 21 Impl Impl NNP cord-010119-t1x9gknd 1455 22 ) ) -RRB- cord-010119-t1x9gknd 1455 23 periods period NNS cord-010119-t1x9gknd 1455 24 1 1 CD cord-010119-t1x9gknd 1455 25 & & CC cord-010119-t1x9gknd 1455 26 2 2 CD cord-010119-t1x9gknd 1455 27 , , , cord-010119-t1x9gknd 1455 28 continued continue VBN cord-010119-t1x9gknd 1455 29 during during IN cord-010119-t1x9gknd 1455 30 Impl Impl NNP cord-010119-t1x9gknd 1455 31 and and CC cord-010119-t1x9gknd 1455 32 Post Post NNP cord-010119-t1x9gknd 1455 33 - - NNP cord-010119-t1x9gknd 1455 34 Impl Impl NNP cord-010119-t1x9gknd 1455 35 periods period NNS cord-010119-t1x9gknd 1455 36 1 1 CD cord-010119-t1x9gknd 1455 37 & & CC cord-010119-t1x9gknd 1455 38 2 2 CD cord-010119-t1x9gknd 1455 39 , , , cord-010119-t1x9gknd 1455 40 returning return VBG cord-010119-t1x9gknd 1455 41 to to IN cord-010119-t1x9gknd 1455 42 the the DT cord-010119-t1x9gknd 1455 43 baseline baseline JJ cord-010119-t1x9gknd 1455 44 rate rate NN cord-010119-t1x9gknd 1455 45 in in IN cord-010119-t1x9gknd 1455 46 Post Post NNP cord-010119-t1x9gknd 1455 47 - - NNP cord-010119-t1x9gknd 1455 48 Impl Impl NNP cord-010119-t1x9gknd 1455 49 periods period NNS cord-010119-t1x9gknd 1455 50 3 3 CD cord-010119-t1x9gknd 1455 51 & & CC cord-010119-t1x9gknd 1455 52 4 4 CD cord-010119-t1x9gknd 1455 53 ( ( -LRB- cord-010119-t1x9gknd 1455 54 Table table NN cord-010119-t1x9gknd 1455 55 ) ) -RRB- cord-010119-t1x9gknd 1455 56 . . . cord-010119-t1x9gknd 1456 1 More More JJR cord-010119-t1x9gknd 1456 2 severe severe JJ cord-010119-t1x9gknd 1456 3 reactions reaction NNS cord-010119-t1x9gknd 1456 4 showed show VBD cord-010119-t1x9gknd 1456 5 an an DT cord-010119-t1x9gknd 1456 6 increasing increase VBG cord-010119-t1x9gknd 1456 7 trend trend NN cord-010119-t1x9gknd 1456 8 that that IN cord-010119-t1x9gknd 1456 9 only only RB cord-010119-t1x9gknd 1456 10 became become VBD cord-010119-t1x9gknd 1456 11 significant significant JJ cord-010119-t1x9gknd 1456 12 in in IN cord-010119-t1x9gknd 1456 13 Post Post NNP cord-010119-t1x9gknd 1456 14 - - NNP cord-010119-t1x9gknd 1456 15 Impl Impl NNP cord-010119-t1x9gknd 1456 16 periods period NNS cord-010119-t1x9gknd 1456 17 3 3 CD cord-010119-t1x9gknd 1456 18 & & CC cord-010119-t1x9gknd 1456 19 4 4 CD cord-010119-t1x9gknd 1456 20 . . . cord-010119-t1x9gknd 1457 1 The the DT cord-010119-t1x9gknd 1457 2 MVA MVA NNP cord-010119-t1x9gknd 1457 3 showed show VBD cord-010119-t1x9gknd 1457 4 the the DT cord-010119-t1x9gknd 1457 5 VVS vvs NN cord-010119-t1x9gknd 1457 6 as as IN cord-010119-t1x9gknd 1457 7 independent independent JJ cord-010119-t1x9gknd 1457 8 factor factor NN cord-010119-t1x9gknd 1457 9 contributing contribute VBG cord-010119-t1x9gknd 1457 10 to to IN cord-010119-t1x9gknd 1457 11 the the DT cord-010119-t1x9gknd 1457 12 increased increase VBN cord-010119-t1x9gknd 1457 13 prefaint prefaint NN cord-010119-t1x9gknd 1457 14 and and CC cord-010119-t1x9gknd 1457 15 more more JJR cord-010119-t1x9gknd 1457 16 severe severe JJ cord-010119-t1x9gknd 1457 17 reactions reaction NNS cord-010119-t1x9gknd 1457 18 . . . cord-010119-t1x9gknd 1458 1 However however RB cord-010119-t1x9gknd 1458 2 , , , cord-010119-t1x9gknd 1458 3 its -PRON- PRP$ cord-010119-t1x9gknd 1458 4 contribution contribution NN cord-010119-t1x9gknd 1458 5 , , , cord-010119-t1x9gknd 1458 6 as as IN cord-010119-t1x9gknd 1458 7 measured measure VBN cord-010119-t1x9gknd 1458 8 by by IN cord-010119-t1x9gknd 1458 9 odds odd NNS cord-010119-t1x9gknd 1458 10 ratios ratio NNS cord-010119-t1x9gknd 1458 11 , , , cord-010119-t1x9gknd 1458 12 was be VBD cord-010119-t1x9gknd 1458 13 consistently consistently RB cord-010119-t1x9gknd 1458 14 lower low JJR cord-010119-t1x9gknd 1458 15 than than IN cord-010119-t1x9gknd 1458 16 those those DT cord-010119-t1x9gknd 1458 17 exerted exert VBN cord-010119-t1x9gknd 1458 18 by by IN cord-010119-t1x9gknd 1458 19 known know VBN cord-010119-t1x9gknd 1458 20 donor donor NN cord-010119-t1x9gknd 1458 21 determinants determinant NNS cord-010119-t1x9gknd 1458 22 of of IN cord-010119-t1x9gknd 1458 23 reaction reaction NN cord-010119-t1x9gknd 1458 24 rates rate NNS cord-010119-t1x9gknd 1458 25 : : : cord-010119-t1x9gknd 1458 26 young young JJ cord-010119-t1x9gknd 1458 27 age age NN cord-010119-t1x9gknd 1458 28 , , , cord-010119-t1x9gknd 1458 29 low low JJ cord-010119-t1x9gknd 1458 30 EBV EBV NNP cord-010119-t1x9gknd 1458 31 , , , cord-010119-t1x9gknd 1458 32 FTD FTD NNP cord-010119-t1x9gknd 1458 33 status status NN cord-010119-t1x9gknd 1458 34 and and CC cord-010119-t1x9gknd 1458 35 collection collection NN cord-010119-t1x9gknd 1458 36 site site NN cord-010119-t1x9gknd 1458 37 ( ( -LRB- cord-010119-t1x9gknd 1458 38 not not RB cord-010119-t1x9gknd 1458 39 shown show VBN cord-010119-t1x9gknd 1458 40 ) ) -RRB- cord-010119-t1x9gknd 1458 41 . . . cord-010119-t1x9gknd 1459 1 Plasma plasma NN cord-010119-t1x9gknd 1459 2 unit unit NN cord-010119-t1x9gknd 1459 3 volume volume NN cord-010119-t1x9gknd 1459 4 increased increase VBD cord-010119-t1x9gknd 1459 5 an an DT cord-010119-t1x9gknd 1459 6 average average NN cord-010119-t1x9gknd 1459 7 of of IN cord-010119-t1x9gknd 1459 8 3.8 3.8 CD cord-010119-t1x9gknd 1459 9 mL ml NN cord-010119-t1x9gknd 1459 10 during during IN cord-010119-t1x9gknd 1459 11 Post Post NNP cord-010119-t1x9gknd 1459 12 - - NNP cord-010119-t1x9gknd 1459 13 Impl Impl NNP cord-010119-t1x9gknd 1459 14 periods period NNS cord-010119-t1x9gknd 1459 15 1 1 CD cord-010119-t1x9gknd 1459 16 & & CC cord-010119-t1x9gknd 1459 17 2 2 CD cord-010119-t1x9gknd 1459 18 from from IN cord-010119-t1x9gknd 1459 19 the the DT cord-010119-t1x9gknd 1459 20 temporally temporally RB cord-010119-t1x9gknd 1459 21 matched match VBN cord-010119-t1x9gknd 1459 22 baseline baseline NN cord-010119-t1x9gknd 1459 23 & & CC cord-010119-t1x9gknd 1459 24 Pre Pre NNP cord-010119-t1x9gknd 1459 25 - - NNP cord-010119-t1x9gknd 1459 26 Impl Impl NNP cord-010119-t1x9gknd 1459 27 period period NN cord-010119-t1x9gknd 1459 28 1 1 CD cord-010119-t1x9gknd 1459 29 . . . cord-010119-t1x9gknd 1460 1 Conclusion conclusion NN cord-010119-t1x9gknd 1460 2 : : : cord-010119-t1x9gknd 1461 1 Following follow VBG cord-010119-t1x9gknd 1461 2 an an DT cord-010119-t1x9gknd 1461 3 initial initial JJ cord-010119-t1x9gknd 1461 4 increase increase NN cord-010119-t1x9gknd 1461 5 in in IN cord-010119-t1x9gknd 1461 6 mild mild JJ cord-010119-t1x9gknd 1461 7 VVRs vvrs NN cord-010119-t1x9gknd 1461 8 during during IN cord-010119-t1x9gknd 1461 9 and and CC cord-010119-t1x9gknd 1461 10 immediately immediately RB cord-010119-t1x9gknd 1461 11 after after IN cord-010119-t1x9gknd 1461 12 implementation implementation NN cord-010119-t1x9gknd 1461 13 of of IN cord-010119-t1x9gknd 1461 14 the the DT cord-010119-t1x9gknd 1461 15 VVS vvs NN cord-010119-t1x9gknd 1461 16 , , , cord-010119-t1x9gknd 1461 17 VVR vvr NN cord-010119-t1x9gknd 1461 18 rates rate NNS cord-010119-t1x9gknd 1461 19 fell fall VBD cord-010119-t1x9gknd 1461 20 back back RB cord-010119-t1x9gknd 1461 21 to to IN cord-010119-t1x9gknd 1461 22 baseline baseline JJ cord-010119-t1x9gknd 1461 23 , , , cord-010119-t1x9gknd 1461 24 suggestive suggestive JJ cord-010119-t1x9gknd 1461 25 of of IN cord-010119-t1x9gknd 1461 26 transient transient JJ cord-010119-t1x9gknd 1461 27 staff staff NN cord-010119-t1x9gknd 1461 28 distraction distraction NN cord-010119-t1x9gknd 1461 29 from from IN cord-010119-t1x9gknd 1461 30 usual usual JJ cord-010119-t1x9gknd 1461 31 donor donor NN cord-010119-t1x9gknd 1461 32 care care NN cord-010119-t1x9gknd 1461 33 , , , cord-010119-t1x9gknd 1461 34 or or CC cord-010119-t1x9gknd 1461 35 a a DT cord-010119-t1x9gknd 1461 36 minor minor JJ cord-010119-t1x9gknd 1461 37 effect effect NN cord-010119-t1x9gknd 1461 38 of of IN cord-010119-t1x9gknd 1461 39 increased increase VBN cord-010119-t1x9gknd 1461 40 blood blood NN cord-010119-t1x9gknd 1461 41 loss loss NN cord-010119-t1x9gknd 1461 42 with with IN cord-010119-t1x9gknd 1461 43 a a DT cord-010119-t1x9gknd 1461 44 superimposed superimpose VBN cord-010119-t1x9gknd 1461 45 improvement improvement NN cord-010119-t1x9gknd 1461 46 trend trend NN cord-010119-t1x9gknd 1461 47 . . . cord-010119-t1x9gknd 1462 1 The the DT cord-010119-t1x9gknd 1462 2 subsequent subsequent JJ cord-010119-t1x9gknd 1462 3 increase increase NN cord-010119-t1x9gknd 1462 4 in in IN cord-010119-t1x9gknd 1462 5 prolonged prolonged JJ cord-010119-t1x9gknd 1462 6 / / SYM cord-010119-t1x9gknd 1462 7 offsite offsite JJ cord-010119-t1x9gknd 1462 8 reactions reaction NNS cord-010119-t1x9gknd 1462 9 and and CC cord-010119-t1x9gknd 1462 10 LOC loc NN cord-010119-t1x9gknd 1462 11 after after IN cord-010119-t1x9gknd 1462 12 prefaint prefaint NN cord-010119-t1x9gknd 1462 13 reactions reaction NNS cord-010119-t1x9gknd 1462 14 had have VBD cord-010119-t1x9gknd 1462 15 already already RB cord-010119-t1x9gknd 1462 16 returned return VBN cord-010119-t1x9gknd 1462 17 to to IN cord-010119-t1x9gknd 1462 18 baseline baseline NN cord-010119-t1x9gknd 1462 19 suggests suggest VBZ cord-010119-t1x9gknd 1462 20 that that IN cord-010119-t1x9gknd 1462 21 staff staff NN cord-010119-t1x9gknd 1462 22 training training NN cord-010119-t1x9gknd 1462 23 , , , cord-010119-t1x9gknd 1462 24 work work NN cord-010119-t1x9gknd 1462 25 load load NN cord-010119-t1x9gknd 1462 26 , , , cord-010119-t1x9gknd 1462 27 donor donor NN cord-010119-t1x9gknd 1462 28 compliance compliance NN cord-010119-t1x9gknd 1462 29 with with IN cord-010119-t1x9gknd 1462 30 mitigation mitigation NN cord-010119-t1x9gknd 1462 31 strategies strategy NNS cord-010119-t1x9gknd 1462 32 and and CC cord-010119-t1x9gknd 1462 33 other other JJ cord-010119-t1x9gknd 1462 34 determinants determinant NNS cord-010119-t1x9gknd 1462 35 of of IN cord-010119-t1x9gknd 1462 36 donor donor NN cord-010119-t1x9gknd 1462 37 reactions reaction NNS cord-010119-t1x9gknd 1462 38 have have VBP cord-010119-t1x9gknd 1462 39 a a DT cord-010119-t1x9gknd 1462 40 far far RB cord-010119-t1x9gknd 1462 41 greater great JJR cord-010119-t1x9gknd 1462 42 effect effect NN cord-010119-t1x9gknd 1462 43 than than IN cord-010119-t1x9gknd 1462 44 the the DT cord-010119-t1x9gknd 1462 45 small small JJ cord-010119-t1x9gknd 1462 46 additional additional JJ cord-010119-t1x9gknd 1462 47 blood blood NN cord-010119-t1x9gknd 1462 48 loss loss NN cord-010119-t1x9gknd 1462 49 due due IN cord-010119-t1x9gknd 1462 50 to to IN cord-010119-t1x9gknd 1462 51 the the DT cord-010119-t1x9gknd 1462 52 VVS vvs NN cord-010119-t1x9gknd 1462 53 . . . cord-010119-t1x9gknd 1463 1 Small small JJ cord-010119-t1x9gknd 1463 2 but but CC cord-010119-t1x9gknd 1463 3 significant significant JJ cord-010119-t1x9gknd 1463 4 increments increment NNS cord-010119-t1x9gknd 1463 5 in in IN cord-010119-t1x9gknd 1463 6 RP rp NN cord-010119-t1x9gknd 1463 7 volume volume NN cord-010119-t1x9gknd 1463 8 improve improve VB cord-010119-t1x9gknd 1463 9 derivative derivative JJ cord-010119-t1x9gknd 1463 10 availability availability NN cord-010119-t1x9gknd 1463 11 and and CC cord-010119-t1x9gknd 1463 12 offset offset VB cord-010119-t1x9gknd 1463 13 the the DT cord-010119-t1x9gknd 1463 14 cost cost NN cord-010119-t1x9gknd 1463 15 of of IN cord-010119-t1x9gknd 1463 16 the the DT cord-010119-t1x9gknd 1463 17 VVS vvs NN cord-010119-t1x9gknd 1463 18 . . . cord-010119-t1x9gknd 1464 1 Comparison comparison NN cord-010119-t1x9gknd 1464 2 of of IN cord-010119-t1x9gknd 1464 3 Vasovagal Vasovagal NNP cord-010119-t1x9gknd 1464 4 and and CC cord-010119-t1x9gknd 1464 5 Citrate Citrate NNP cord-010119-t1x9gknd 1464 6 Reaction Reaction NNP cord-010119-t1x9gknd 1464 7 Rates Rates NNPS cord-010119-t1x9gknd 1464 8 in in IN cord-010119-t1x9gknd 1464 9 Donors donor NNS cord-010119-t1x9gknd 1465 1 According accord VBG cord-010119-t1x9gknd 1465 2 to to IN cord-010119-t1x9gknd 1465 3 Type Type NNP cord-010119-t1x9gknd 1465 4 of of IN cord-010119-t1x9gknd 1465 5 Apheresis Apheresis NNP cord-010119-t1x9gknd 1465 6 Procedure Procedure NNP cord-010119-t1x9gknd 1465 7 Pierre Pierre NNP cord-010119-t1x9gknd 1465 8 Robillard Robillard NNP cord-010119-t1x9gknd 1466 1 * * NFP cord-010119-t1x9gknd 1466 2 1 1 CD cord-010119-t1x9gknd 1466 3 and and CC cord-010119-t1x9gknd 1466 4 Yves Yves NNP cord-010119-t1x9gknd 1466 5 Gr Gr NNP cord-010119-t1x9gknd 1466 6 egoire egoire VBD cord-010119-t1x9gknd 1466 7 2 2 CD cord-010119-t1x9gknd 1466 8 . . . cord-010119-t1x9gknd 1467 1 1 1 LS cord-010119-t1x9gknd 1468 1 Hema Hema NNP cord-010119-t1x9gknd 1468 2 - - HYPH cord-010119-t1x9gknd 1468 3 Quebec Quebec NNP cord-010119-t1x9gknd 1468 4 , , , cord-010119-t1x9gknd 1468 5 2 2 CD cord-010119-t1x9gknd 1468 6 H h NN cord-010119-t1x9gknd 1468 7 ema ema NNP cord-010119-t1x9gknd 1468 8 - - HYPH cord-010119-t1x9gknd 1468 9 Qu Qu NNP cord-010119-t1x9gknd 1468 10 ebec ebec NNP cord-010119-t1x9gknd 1468 11 Background Background NNP cord-010119-t1x9gknd 1468 12 / / SYM cord-010119-t1x9gknd 1468 13 Case Case NNP cord-010119-t1x9gknd 1468 14 Studies Studies NNPS cord-010119-t1x9gknd 1468 15 : : : cord-010119-t1x9gknd 1469 1 Apheresis apheresis NN cord-010119-t1x9gknd 1469 2 procedures procedure NNS cord-010119-t1x9gknd 1469 3 expose expose VBP cord-010119-t1x9gknd 1469 4 donors donor NNS cord-010119-t1x9gknd 1469 5 to to IN cord-010119-t1x9gknd 1469 6 various various JJ cord-010119-t1x9gknd 1469 7 volumes volume NNS cord-010119-t1x9gknd 1469 8 of of IN cord-010119-t1x9gknd 1469 9 citrate citrate NN cord-010119-t1x9gknd 1469 10 depending depend VBG cord-010119-t1x9gknd 1469 11 upon upon IN cord-010119-t1x9gknd 1469 12 type type NN cord-010119-t1x9gknd 1469 13 and and CC cord-010119-t1x9gknd 1469 14 length length NN cord-010119-t1x9gknd 1469 15 of of IN cord-010119-t1x9gknd 1469 16 procedure procedure NN cord-010119-t1x9gknd 1469 17 and and CC cord-010119-t1x9gknd 1469 18 type type NN cord-010119-t1x9gknd 1469 19 of of IN cord-010119-t1x9gknd 1469 20 machine machine NN cord-010119-t1x9gknd 1469 21 used use VBN cord-010119-t1x9gknd 1469 22 . . . cord-010119-t1x9gknd 1470 1 Citrate Citrate NNP cord-010119-t1x9gknd 1470 2 reaction reaction NN cord-010119-t1x9gknd 1470 3 ( ( -LRB- cord-010119-t1x9gknd 1470 4 CR cr NN cord-010119-t1x9gknd 1470 5 ) ) -RRB- cord-010119-t1x9gknd 1470 6 results result VBZ cord-010119-t1x9gknd 1470 7 from from IN cord-010119-t1x9gknd 1470 8 various various JJ cord-010119-t1x9gknd 1470 9 degrees degree NNS cord-010119-t1x9gknd 1470 10 of of IN cord-010119-t1x9gknd 1470 11 hypocalcemia hypocalcemia NN cord-010119-t1x9gknd 1470 12 in in IN cord-010119-t1x9gknd 1470 13 donors donor NNS cord-010119-t1x9gknd 1470 14 . . . cord-010119-t1x9gknd 1471 1 Blood blood NN cord-010119-t1x9gknd 1471 2 volumes volume NNS cord-010119-t1x9gknd 1471 3 taken take VBN cord-010119-t1x9gknd 1471 4 from from IN cord-010119-t1x9gknd 1471 5 donors donor NNS cord-010119-t1x9gknd 1471 6 vary vary VBP cord-010119-t1x9gknd 1471 7 according accord VBG cord-010119-t1x9gknd 1471 8 to to IN cord-010119-t1x9gknd 1471 9 type type NN cord-010119-t1x9gknd 1471 10 of of IN cord-010119-t1x9gknd 1471 11 procedure procedure NN cord-010119-t1x9gknd 1471 12 and and CC cord-010119-t1x9gknd 1471 13 use use NN cord-010119-t1x9gknd 1471 14 of of IN cord-010119-t1x9gknd 1471 15 volume volume NN cord-010119-t1x9gknd 1471 16 replacement replacement NN cord-010119-t1x9gknd 1471 17 . . . cord-010119-t1x9gknd 1472 1 Loss loss NN cord-010119-t1x9gknd 1472 2 of of IN cord-010119-t1x9gknd 1472 3 blood blood NN cord-010119-t1x9gknd 1472 4 volume volume NN cord-010119-t1x9gknd 1472 5 is be VBZ cord-010119-t1x9gknd 1472 6 in in IN cord-010119-t1x9gknd 1472 7 part part NN cord-010119-t1x9gknd 1472 8 responsible responsible JJ cord-010119-t1x9gknd 1472 9 for for IN cord-010119-t1x9gknd 1472 10 the the DT cord-010119-t1x9gknd 1472 11 occurrence occurrence NN cord-010119-t1x9gknd 1472 12 of of IN cord-010119-t1x9gknd 1472 13 vasovagal vasovagal JJ cord-010119-t1x9gknd 1472 14 reactions reaction NNS cord-010119-t1x9gknd 1472 15 ( ( -LRB- cord-010119-t1x9gknd 1472 16 VVR vvr NN cord-010119-t1x9gknd 1472 17 ) ) -RRB- cord-010119-t1x9gknd 1472 18 . . . cord-010119-t1x9gknd 1473 1 This this DT cord-010119-t1x9gknd 1473 2 analysis analysis NN cord-010119-t1x9gknd 1473 3 was be VBD cord-010119-t1x9gknd 1473 4 conducted conduct VBN cord-010119-t1x9gknd 1473 5 to to TO cord-010119-t1x9gknd 1473 6 estimate estimate VB cord-010119-t1x9gknd 1473 7 the the DT cord-010119-t1x9gknd 1473 8 incidence incidence NN cord-010119-t1x9gknd 1473 9 of of IN cord-010119-t1x9gknd 1473 10 CR CR NNP cord-010119-t1x9gknd 1473 11 and and CC cord-010119-t1x9gknd 1473 12 VVR VVR NNP cord-010119-t1x9gknd 1473 13 according accord VBG cord-010119-t1x9gknd 1473 14 to to IN cord-010119-t1x9gknd 1473 15 various various JJ cord-010119-t1x9gknd 1473 16 types type NNS cord-010119-t1x9gknd 1473 17 of of IN cord-010119-t1x9gknd 1473 18 apheresis apheresis NN cord-010119-t1x9gknd 1473 19 procedures procedure NNS cord-010119-t1x9gknd 1473 20 performed perform VBN cord-010119-t1x9gknd 1473 21 at at IN cord-010119-t1x9gknd 1473 22 our -PRON- PRP$ cord-010119-t1x9gknd 1473 23 blood blood NN cord-010119-t1x9gknd 1473 24 center center NN cord-010119-t1x9gknd 1473 25 . . . cord-010119-t1x9gknd 1474 1 ( ( -LRB- cord-010119-t1x9gknd 1474 2 YFV YFV NNP cord-010119-t1x9gknd 1474 3 ) ) -RRB- cord-010119-t1x9gknd 1474 4 were be VBD cord-010119-t1x9gknd 1474 5 reported report VBN cord-010119-t1x9gknd 1474 6 in in IN cord-010119-t1x9gknd 1474 7 Some some DT cord-010119-t1x9gknd 1474 8 Brazilian brazilian JJ cord-010119-t1x9gknd 1474 9 states state NNS cord-010119-t1x9gknd 1474 10 -Rio -Rio . cord-010119-t1x9gknd 1474 11 de de NNP cord-010119-t1x9gknd 1474 12 Janeiro Janeiro NNP cord-010119-t1x9gknd 1474 13 , , , cord-010119-t1x9gknd 1474 14 Sao Sao NNP cord-010119-t1x9gknd 1474 15 Paulo Paulo NNP cord-010119-t1x9gknd 1474 16 , , , cord-010119-t1x9gknd 1474 17 Minas Minas NNP cord-010119-t1x9gknd 1474 18 Gerais Gerais NNP cord-010119-t1x9gknd 1474 19 and and CC cord-010119-t1x9gknd 1474 20 Espírito Espírito NNP cord-010119-t1x9gknd 1474 21 Santo Santo NNP cord-010119-t1x9gknd 1474 22 , , , cord-010119-t1x9gknd 1474 23 mainly mainly RB cord-010119-t1x9gknd 1474 24 . . . cord-010119-t1x9gknd 1475 1 The the DT cord-010119-t1x9gknd 1475 2 vectors vector NNS cord-010119-t1x9gknd 1475 3 of of IN cord-010119-t1x9gknd 1475 4 those those DT cord-010119-t1x9gknd 1475 5 cases case NNS cord-010119-t1x9gknd 1475 6 were be VBD cord-010119-t1x9gknd 1475 7 mosquitoes mosquito NNS cord-010119-t1x9gknd 1475 8 from from IN cord-010119-t1x9gknd 1475 9 the the DT cord-010119-t1x9gknd 1475 10 Haemagogus Haemagogus NNP cord-010119-t1x9gknd 1475 11 and and CC cord-010119-t1x9gknd 1475 12 Sabethes Sabethes NNP cord-010119-t1x9gknd 1475 13 genders gender NNS cord-010119-t1x9gknd 1475 14 , , , cord-010119-t1x9gknd 1475 15 whose whose WP$ cord-010119-t1x9gknd 1475 16 habitat habitat NN cord-010119-t1x9gknd 1475 17 is be VBZ cord-010119-t1x9gknd 1475 18 the the DT cord-010119-t1x9gknd 1475 19 tropical tropical JJ cord-010119-t1x9gknd 1475 20 forests forest NNS cord-010119-t1x9gknd 1475 21 . . . cord-010119-t1x9gknd 1476 1 Since since IN cord-010119-t1x9gknd 1476 2 many many JJ cord-010119-t1x9gknd 1476 3 Brazilian brazilian JJ cord-010119-t1x9gknd 1476 4 urban urban JJ cord-010119-t1x9gknd 1476 5 areas area NNS cord-010119-t1x9gknd 1476 6 are be VBP cord-010119-t1x9gknd 1476 7 very very RB cord-010119-t1x9gknd 1476 8 close close JJ cord-010119-t1x9gknd 1476 9 to to TO cord-010119-t1x9gknd 1476 10 rain rain VB cord-010119-t1x9gknd 1476 11 forests forest NNS cord-010119-t1x9gknd 1476 12 , , , cord-010119-t1x9gknd 1476 13 there there EX cord-010119-t1x9gknd 1476 14 is be VBZ cord-010119-t1x9gknd 1476 15 an an DT cord-010119-t1x9gknd 1476 16 outbreak outbreak NN cord-010119-t1x9gknd 1476 17 risk risk NN cord-010119-t1x9gknd 1476 18 in in IN cord-010119-t1x9gknd 1476 19 those those DT cord-010119-t1x9gknd 1476 20 areas area NNS cord-010119-t1x9gknd 1476 21 , , , cord-010119-t1x9gknd 1476 22 where where WRB cord-010119-t1x9gknd 1476 23 the the DT cord-010119-t1x9gknd 1476 24 infection infection NN cord-010119-t1x9gknd 1476 25 is be VBZ cord-010119-t1x9gknd 1476 26 transmitted transmit VBN cord-010119-t1x9gknd 1476 27 by by IN cord-010119-t1x9gknd 1476 28 the the DT cord-010119-t1x9gknd 1476 29 Aedes Aedes NNP cord-010119-t1x9gknd 1476 30 mosquitoes mosquito NNS cord-010119-t1x9gknd 1476 31 . . . cord-010119-t1x9gknd 1477 1 In in IN cord-010119-t1x9gknd 1477 2 order order NN cord-010119-t1x9gknd 1477 3 to to TO cord-010119-t1x9gknd 1477 4 minimize minimize VB cord-010119-t1x9gknd 1477 5 this this DT cord-010119-t1x9gknd 1477 6 risk risk NN cord-010119-t1x9gknd 1477 7 , , , cord-010119-t1x9gknd 1477 8 Rio Rio NNP cord-010119-t1x9gknd 1477 9 de de NNP cord-010119-t1x9gknd 1477 10 Janeiro Janeiro NNP cord-010119-t1x9gknd 1477 11 health health NN cord-010119-t1x9gknd 1477 12 authorities authority NNS cord-010119-t1x9gknd 1477 13 decided decide VBD cord-010119-t1x9gknd 1477 14 to to TO cord-010119-t1x9gknd 1477 15 promote promote VB cord-010119-t1x9gknd 1477 16 a a DT cord-010119-t1x9gknd 1477 17 mass mass JJ cord-010119-t1x9gknd 1477 18 vaccination vaccination NN cord-010119-t1x9gknd 1477 19 in in IN cord-010119-t1x9gknd 1477 20 late late JJ cord-010119-t1x9gknd 1477 21 March March NNP cord-010119-t1x9gknd 1477 22 , , , cord-010119-t1x9gknd 1477 23 2017 2017 CD cord-010119-t1x9gknd 1477 24 . . . cord-010119-t1x9gknd 1478 1 The the DT cord-010119-t1x9gknd 1478 2 vaccine vaccine NN cord-010119-t1x9gknd 1478 3 is be VBZ cord-010119-t1x9gknd 1478 4 produced produce VBN cord-010119-t1x9gknd 1478 5 with with IN cord-010119-t1x9gknd 1478 6 live live JJ cord-010119-t1x9gknd 1478 7 and and CC cord-010119-t1x9gknd 1478 8 attenuated attenuated JJ cord-010119-t1x9gknd 1478 9 YFV YFV NNP cord-010119-t1x9gknd 1478 10 , , , cord-010119-t1x9gknd 1478 11 which which WDT cord-010119-t1x9gknd 1478 12 can can MD cord-010119-t1x9gknd 1478 13 circulate circulate VB cord-010119-t1x9gknd 1478 14 for for IN cord-010119-t1x9gknd 1478 15 at at RB cord-010119-t1x9gknd 1478 16 least least JJS cord-010119-t1x9gknd 1478 17 4 4 CD cord-010119-t1x9gknd 1478 18 weeks week NNS cord-010119-t1x9gknd 1478 19 after after IN cord-010119-t1x9gknd 1478 20 vaccination vaccination NN cord-010119-t1x9gknd 1478 21 . . . cord-010119-t1x9gknd 1479 1 In in IN cord-010119-t1x9gknd 1479 2 some some DT cord-010119-t1x9gknd 1479 3 individuals individual NNS cord-010119-t1x9gknd 1479 4 , , , cord-010119-t1x9gknd 1479 5 the the DT cord-010119-t1x9gknd 1479 6 vaccine vaccine NN cord-010119-t1x9gknd 1479 7 can can MD cord-010119-t1x9gknd 1479 8 elicit elicit VB cord-010119-t1x9gknd 1479 9 viscerotropic viscerotropic JJ cord-010119-t1x9gknd 1479 10 effects effect NNS cord-010119-t1x9gknd 1479 11 and and CC cord-010119-t1x9gknd 1479 12 sometimes sometimes RB cord-010119-t1x9gknd 1479 13 severe severe JJ cord-010119-t1x9gknd 1479 14 diseases disease NNS cord-010119-t1x9gknd 1479 15 . . . cord-010119-t1x9gknd 1480 1 Due due IN cord-010119-t1x9gknd 1480 2 to to IN cord-010119-t1x9gknd 1480 3 that that DT cord-010119-t1x9gknd 1480 4 , , , cord-010119-t1x9gknd 1480 5 Brazilian brazilian JJ cord-010119-t1x9gknd 1480 6 blood blood NN cord-010119-t1x9gknd 1480 7 regulation regulation NN cord-010119-t1x9gknd 1480 8 authority authority NN cord-010119-t1x9gknd 1480 9 established establish VBD cord-010119-t1x9gknd 1480 10 a a DT cord-010119-t1x9gknd 1480 11 4 4 CD cord-010119-t1x9gknd 1480 12 week week NN cord-010119-t1x9gknd 1480 13 deferral deferral NN cord-010119-t1x9gknd 1480 14 period period NN cord-010119-t1x9gknd 1480 15 after after IN cord-010119-t1x9gknd 1480 16 YFV YFV NNP cord-010119-t1x9gknd 1480 17 vaccination vaccination NN cord-010119-t1x9gknd 1480 18 . . . cord-010119-t1x9gknd 1481 1 This this DT cord-010119-t1x9gknd 1481 2 action action NN cord-010119-t1x9gknd 1481 3 could could MD cord-010119-t1x9gknd 1481 4 dramatically dramatically RB cord-010119-t1x9gknd 1481 5 affect affect VB cord-010119-t1x9gknd 1481 6 the the DT cord-010119-t1x9gknd 1481 7 availability availability NN cord-010119-t1x9gknd 1481 8 of of IN cord-010119-t1x9gknd 1481 9 blood blood NN cord-010119-t1x9gknd 1481 10 donors donor NNS cord-010119-t1x9gknd 1481 11 . . . cord-010119-t1x9gknd 1482 1 This this DT cord-010119-t1x9gknd 1482 2 study study NN cord-010119-t1x9gknd 1482 3 shows show VBZ cord-010119-t1x9gknd 1482 4 the the DT cord-010119-t1x9gknd 1482 5 measures measure NNS cord-010119-t1x9gknd 1482 6 taken take VBN cord-010119-t1x9gknd 1482 7 by by IN cord-010119-t1x9gknd 1482 8 Rio Rio NNP cord-010119-t1x9gknd 1482 9 de de NNP cord-010119-t1x9gknd 1482 10 Janeiro Janeiro NNP cord-010119-t1x9gknd 1482 11 blood blood NN cord-010119-t1x9gknd 1482 12 center center NN cord-010119-t1x9gknd 1482 13 to to TO cord-010119-t1x9gknd 1482 14 circumvent circumvent VB cord-010119-t1x9gknd 1482 15 this this DT cord-010119-t1x9gknd 1482 16 risk risk NN cord-010119-t1x9gknd 1482 17 and and CC cord-010119-t1x9gknd 1482 18 attract attract VB cord-010119-t1x9gknd 1482 19 more more JJR cord-010119-t1x9gknd 1482 20 donors donor NNS cord-010119-t1x9gknd 1482 21 . . . cord-010119-t1x9gknd 1483 1 Study Study NNP cord-010119-t1x9gknd 1483 2 Design Design NNP cord-010119-t1x9gknd 1483 3 / / SYM cord-010119-t1x9gknd 1483 4 Method method NN cord-010119-t1x9gknd 1483 5 : : : cord-010119-t1x9gknd 1484 1 The the DT cord-010119-t1x9gknd 1484 2 strategy strategy NN cord-010119-t1x9gknd 1484 3 consisted consist VBD cord-010119-t1x9gknd 1484 4 in in IN cord-010119-t1x9gknd 1484 5 offering offer VBG cord-010119-t1x9gknd 1484 6 the the DT cord-010119-t1x9gknd 1484 7 population population NN cord-010119-t1x9gknd 1484 8 , , , cord-010119-t1x9gknd 1484 9 at at IN cord-010119-t1x9gknd 1484 10 a a DT cord-010119-t1x9gknd 1484 11 single single JJ cord-010119-t1x9gknd 1484 12 place place NN cord-010119-t1x9gknd 1484 13 -the -the ADD cord-010119-t1x9gknd 1484 14 blood blood NN cord-010119-t1x9gknd 1484 15 center center NN cord-010119-t1x9gknd 1484 16 -the -the DT cord-010119-t1x9gknd 1484 17 possibility possibility NN cord-010119-t1x9gknd 1484 18 to to TO cord-010119-t1x9gknd 1484 19 donate donate VB cord-010119-t1x9gknd 1484 20 blood blood NN cord-010119-t1x9gknd 1484 21 and and CC cord-010119-t1x9gknd 1484 22 , , , cord-010119-t1x9gknd 1484 23 immediately immediately RB cord-010119-t1x9gknd 1484 24 after after IN cord-010119-t1x9gknd 1484 25 donation donation NN cord-010119-t1x9gknd 1484 26 , , , cord-010119-t1x9gknd 1484 27 to to TO cord-010119-t1x9gknd 1484 28 get get VB cord-010119-t1x9gknd 1484 29 vaccinated vaccinate VBN cord-010119-t1x9gknd 1484 30 against against IN cord-010119-t1x9gknd 1484 31 YFV YFV NNP cord-010119-t1x9gknd 1484 32 . . . cord-010119-t1x9gknd 1485 1 There there EX cord-010119-t1x9gknd 1485 2 were be VBD cord-010119-t1x9gknd 1485 3 no no DT cord-010119-t1x9gknd 1485 4 financial financial JJ cord-010119-t1x9gknd 1485 5 advantages advantage NNS cord-010119-t1x9gknd 1485 6 to to IN cord-010119-t1x9gknd 1485 7 the the DT cord-010119-t1x9gknd 1485 8 donors donor NNS cord-010119-t1x9gknd 1485 9 , , , cord-010119-t1x9gknd 1485 10 since since IN cord-010119-t1x9gknd 1485 11 YFV YFV NNP cord-010119-t1x9gknd 1485 12 vaccine vaccine NN cord-010119-t1x9gknd 1485 13 is be VBZ cord-010119-t1x9gknd 1485 14 completely completely RB cord-010119-t1x9gknd 1485 15 free free JJ cord-010119-t1x9gknd 1485 16 of of IN cord-010119-t1x9gknd 1485 17 charge charge NN cord-010119-t1x9gknd 1485 18 for for IN cord-010119-t1x9gknd 1485 19 any any DT cord-010119-t1x9gknd 1485 20 Brazilian brazilian JJ cord-010119-t1x9gknd 1485 21 citizen citizen NN cord-010119-t1x9gknd 1485 22 . . . cord-010119-t1x9gknd 1486 1 The the DT cord-010119-t1x9gknd 1486 2 vaccine vaccine NN cord-010119-t1x9gknd 1486 3 was be VBD cord-010119-t1x9gknd 1486 4 administrated administrate VBN cord-010119-t1x9gknd 1486 5 by by IN cord-010119-t1x9gknd 1486 6 trained train VBN cord-010119-t1x9gknd 1486 7 nurses nurse NNS cord-010119-t1x9gknd 1486 8 , , , cord-010119-t1x9gknd 1486 9 in in IN cord-010119-t1x9gknd 1486 10 an an DT cord-010119-t1x9gknd 1486 11 office office NN cord-010119-t1x9gknd 1486 12 close close JJ cord-010119-t1x9gknd 1486 13 to to IN cord-010119-t1x9gknd 1486 14 the the DT cord-010119-t1x9gknd 1486 15 donors donor NNS cord-010119-t1x9gknd 1486 16 session session NN cord-010119-t1x9gknd 1486 17 . . . cord-010119-t1x9gknd 1487 1 If if IN cord-010119-t1x9gknd 1487 2 , , , cord-010119-t1x9gknd 1487 3 for for IN cord-010119-t1x9gknd 1487 4 any any DT cord-010119-t1x9gknd 1487 5 reason reason NN cord-010119-t1x9gknd 1487 6 , , , cord-010119-t1x9gknd 1487 7 the the DT cord-010119-t1x9gknd 1487 8 prospective prospective JJ cord-010119-t1x9gknd 1487 9 donors donor NNS cord-010119-t1x9gknd 1487 10 were be VBD cord-010119-t1x9gknd 1487 11 not not RB cord-010119-t1x9gknd 1487 12 able able JJ cord-010119-t1x9gknd 1487 13 to to TO cord-010119-t1x9gknd 1487 14 donate donate VB cord-010119-t1x9gknd 1487 15 , , , cord-010119-t1x9gknd 1487 16 the the DT cord-010119-t1x9gknd 1487 17 vaccine vaccine NN cord-010119-t1x9gknd 1487 18 was be VBD cord-010119-t1x9gknd 1487 19 also also RB cord-010119-t1x9gknd 1487 20 offered offer VBN cord-010119-t1x9gknd 1487 21 to to IN cord-010119-t1x9gknd 1487 22 them -PRON- PRP cord-010119-t1x9gknd 1487 23 , , , cord-010119-t1x9gknd 1487 24 provide provide VB cord-010119-t1x9gknd 1487 25 there there EX cord-010119-t1x9gknd 1487 26 were be VBD cord-010119-t1x9gknd 1487 27 no no DT cord-010119-t1x9gknd 1487 28 contraindications contraindication NNS cord-010119-t1x9gknd 1487 29 . . . cord-010119-t1x9gknd 1488 1 The the DT cord-010119-t1x9gknd 1488 2 blood blood NN cord-010119-t1x9gknd 1488 3 center center NN cord-010119-t1x9gknd 1488 4 annnounced annnounce VBD cord-010119-t1x9gknd 1488 5 just just RB cord-010119-t1x9gknd 1488 6 before before IN cord-010119-t1x9gknd 1488 7 the the DT cord-010119-t1x9gknd 1488 8 mass mass JJ cord-010119-t1x9gknd 1488 9 vacination vacination NN cord-010119-t1x9gknd 1488 10 campaign campaign NN cord-010119-t1x9gknd 1488 11 launching launch VBG cord-010119-t1x9gknd 1488 12 that that IN cord-010119-t1x9gknd 1488 13 it -PRON- PRP cord-010119-t1x9gknd 1488 14 would would MD cord-010119-t1x9gknd 1488 15 vaccinate vaccinate VB cord-010119-t1x9gknd 1488 16 600 600 CD cord-010119-t1x9gknd 1488 17 people people NNS cord-010119-t1x9gknd 1488 18 who who WP cord-010119-t1x9gknd 1488 19 came come VBD cord-010119-t1x9gknd 1488 20 to to IN cord-010119-t1x9gknd 1488 21 the the DT cord-010119-t1x9gknd 1488 22 blood blood NN cord-010119-t1x9gknd 1488 23 center center NN cord-010119-t1x9gknd 1488 24 to to TO cord-010119-t1x9gknd 1488 25 donate donate VB cord-010119-t1x9gknd 1488 26 blood blood NN cord-010119-t1x9gknd 1488 27 . . . cord-010119-t1x9gknd 1489 1 If if IN cord-010119-t1x9gknd 1489 2 , , , cord-010119-t1x9gknd 1489 3 for for IN cord-010119-t1x9gknd 1489 4 any any DT cord-010119-t1x9gknd 1489 5 reason reason NN cord-010119-t1x9gknd 1489 6 , , , cord-010119-t1x9gknd 1489 7 the the DT cord-010119-t1x9gknd 1489 8 prospective prospective JJ cord-010119-t1x9gknd 1489 9 donors donor NNS cord-010119-t1x9gknd 1489 10 were be VBD cord-010119-t1x9gknd 1489 11 not not RB cord-010119-t1x9gknd 1489 12 able able JJ cord-010119-t1x9gknd 1489 13 to to TO cord-010119-t1x9gknd 1489 14 donate donate VB cord-010119-t1x9gknd 1489 15 , , , cord-010119-t1x9gknd 1489 16 the the DT cord-010119-t1x9gknd 1489 17 vaccine vaccine NN cord-010119-t1x9gknd 1489 18 was be VBD cord-010119-t1x9gknd 1489 19 also also RB cord-010119-t1x9gknd 1489 20 offered offer VBN cord-010119-t1x9gknd 1489 21 to to IN cord-010119-t1x9gknd 1489 22 them -PRON- PRP cord-010119-t1x9gknd 1489 23 , , , cord-010119-t1x9gknd 1489 24 provide provide VB cord-010119-t1x9gknd 1489 25 there there EX cord-010119-t1x9gknd 1489 26 were be VBD cord-010119-t1x9gknd 1489 27 no no DT cord-010119-t1x9gknd 1489 28 contraindications contraindication NNS cord-010119-t1x9gknd 1489 29 . . . cord-010119-t1x9gknd 1490 1 Results/ Results/ . cord-010119-t1x9gknd 1491 1 Finding finding NN cord-010119-t1x9gknd 1491 2 : : : cord-010119-t1x9gknd 1491 3 During during IN cord-010119-t1x9gknd 1491 4 the the DT cord-010119-t1x9gknd 1491 5 five five CD cord-010119-t1x9gknd 1491 6 days day NNS cord-010119-t1x9gknd 1491 7 of of IN cord-010119-t1x9gknd 1491 8 campaign campaign NN cord-010119-t1x9gknd 1491 9 , , , cord-010119-t1x9gknd 1491 10 we -PRON- PRP cord-010119-t1x9gknd 1491 11 received receive VBD cord-010119-t1x9gknd 1491 12 3,351 3,351 CD cord-010119-t1x9gknd 1491 13 blood blood NN cord-010119-t1x9gknd 1491 14 donors donor NNS cord-010119-t1x9gknd 1491 15 candidates candidate NNS cord-010119-t1x9gknd 1491 16 ; ; : cord-010119-t1x9gknd 1491 17 from from IN cord-010119-t1x9gknd 1491 18 those those DT cord-010119-t1x9gknd 1491 19 , , , cord-010119-t1x9gknd 1491 20 2,449 2,449 CD cord-010119-t1x9gknd 1491 21 were be VBD cord-010119-t1x9gknd 1491 22 accepted accept VBN cord-010119-t1x9gknd 1491 23 as as IN cord-010119-t1x9gknd 1491 24 a a DT cord-010119-t1x9gknd 1491 25 blood blood NN cord-010119-t1x9gknd 1491 26 donor donor NN cord-010119-t1x9gknd 1491 27 , , , cord-010119-t1x9gknd 1491 28 after after IN cord-010119-t1x9gknd 1491 29 medical medical JJ cord-010119-t1x9gknd 1491 30 interview interview NN cord-010119-t1x9gknd 1491 31 . . . cord-010119-t1x9gknd 1492 1 The the DT cord-010119-t1x9gknd 1492 2 deferral deferral NN cord-010119-t1x9gknd 1492 3 rate rate NN cord-010119-t1x9gknd 1492 4 was be VBD cord-010119-t1x9gknd 1492 5 26.9 26.9 CD cord-010119-t1x9gknd 1492 6 % % NN cord-010119-t1x9gknd 1492 7 . . . cord-010119-t1x9gknd 1493 1 At at IN cord-010119-t1x9gknd 1493 2 the the DT cord-010119-t1x9gknd 1493 3 same same JJ cord-010119-t1x9gknd 1493 4 period period NN cord-010119-t1x9gknd 1493 5 of of IN cord-010119-t1x9gknd 1493 6 the the DT cord-010119-t1x9gknd 1493 7 year year NN cord-010119-t1x9gknd 1493 8 2016 2016 CD cord-010119-t1x9gknd 1493 9 , , , cord-010119-t1x9gknd 1493 10 there there EX cord-010119-t1x9gknd 1493 11 were be VBD cord-010119-t1x9gknd 1493 12 1,215 1,215 CD cord-010119-t1x9gknd 1493 13 prospective prospective JJ cord-010119-t1x9gknd 1493 14 donors donor NNS cord-010119-t1x9gknd 1493 15 , , , cord-010119-t1x9gknd 1493 16 and and CC cord-010119-t1x9gknd 1493 17 883 883 CD cord-010119-t1x9gknd 1493 18 blood blood NN cord-010119-t1x9gknd 1493 19 donations donation NNS cord-010119-t1x9gknd 1493 20 . . . cord-010119-t1x9gknd 1494 1 The the DT cord-010119-t1x9gknd 1494 2 deferral deferral NN cord-010119-t1x9gknd 1494 3 rate rate NN cord-010119-t1x9gknd 1494 4 was be VBD cord-010119-t1x9gknd 1494 5 27.3 27.3 CD cord-010119-t1x9gknd 1494 6 % % NN cord-010119-t1x9gknd 1494 7 . . . cord-010119-t1x9gknd 1495 1 The the DT cord-010119-t1x9gknd 1495 2 " " `` cord-010119-t1x9gknd 1495 3 Get get VB cord-010119-t1x9gknd 1495 4 vaccinated vaccinate VBN cord-010119-t1x9gknd 1495 5 against against IN cord-010119-t1x9gknd 1495 6 YFV YFV NNP cord-010119-t1x9gknd 1495 7 . . . cord-010119-t1x9gknd 1495 8 . . . cord-010119-t1x9gknd 1496 1 .but .but . cord-010119-t1x9gknd 1497 1 give give VB cord-010119-t1x9gknd 1497 2 blood blood NN cord-010119-t1x9gknd 1497 3 before before IN cord-010119-t1x9gknd 1497 4 " " '' cord-010119-t1x9gknd 1497 5 campaign campaign NN cord-010119-t1x9gknd 1497 6 was be VBD cord-010119-t1x9gknd 1497 7 able able JJ cord-010119-t1x9gknd 1497 8 to to TO cord-010119-t1x9gknd 1497 9 attract attract VB cord-010119-t1x9gknd 1497 10 , , , cord-010119-t1x9gknd 1497 11 in in IN cord-010119-t1x9gknd 1497 12 a a DT cord-010119-t1x9gknd 1497 13 five five CD cord-010119-t1x9gknd 1497 14 day day NN cord-010119-t1x9gknd 1497 15 period period NN cord-010119-t1x9gknd 1497 16 , , , cord-010119-t1x9gknd 1497 17 1,566 1,566 CD cord-010119-t1x9gknd 1497 18 additional additional JJ cord-010119-t1x9gknd 1497 19 donors donor NNS cord-010119-t1x9gknd 1497 20 , , , cord-010119-t1x9gknd 1497 21 compared compare VBN cord-010119-t1x9gknd 1497 22 to to IN cord-010119-t1x9gknd 1497 23 2016 2016 CD cord-010119-t1x9gknd 1497 24 same same JJ cord-010119-t1x9gknd 1497 25 dates date NNS cord-010119-t1x9gknd 1497 26 . . . cord-010119-t1x9gknd 1498 1 That that DT cord-010119-t1x9gknd 1498 2 represents represent VBZ cord-010119-t1x9gknd 1498 3 a a DT cord-010119-t1x9gknd 1498 4 177.34 177.34 CD cord-010119-t1x9gknd 1498 5 % % NN cord-010119-t1x9gknd 1498 6 increase increase NN cord-010119-t1x9gknd 1498 7 in in IN cord-010119-t1x9gknd 1498 8 the the DT cord-010119-t1x9gknd 1498 9 number number NN cord-010119-t1x9gknd 1498 10 of of IN cord-010119-t1x9gknd 1498 11 blood blood NN cord-010119-t1x9gknd 1498 12 donations donation NNS cord-010119-t1x9gknd 1498 13 , , , cord-010119-t1x9gknd 1498 14 without without IN cord-010119-t1x9gknd 1498 15 deferral deferral NN cord-010119-t1x9gknd 1498 16 rate rate NN cord-010119-t1x9gknd 1498 17 increment increment NN cord-010119-t1x9gknd 1498 18 . . . cord-010119-t1x9gknd 1499 1 There there EX cord-010119-t1x9gknd 1499 2 was be VBD cord-010119-t1x9gknd 1499 3 a a DT cord-010119-t1x9gknd 1499 4 slight slight JJ cord-010119-t1x9gknd 1499 5 increase increase NN cord-010119-t1x9gknd 1499 6 in in IN cord-010119-t1x9gknd 1499 7 the the DT cord-010119-t1x9gknd 1499 8 proportion proportion NN cord-010119-t1x9gknd 1499 9 of of IN cord-010119-t1x9gknd 1499 10 first first JJ cord-010119-t1x9gknd 1499 11 - - HYPH cord-010119-t1x9gknd 1499 12 time time NN cord-010119-t1x9gknd 1499 13 donors donor NNS cord-010119-t1x9gknd 1499 14 , , , cord-010119-t1x9gknd 1499 15 from from IN cord-010119-t1x9gknd 1499 16 42.7 42.7 CD cord-010119-t1x9gknd 1499 17 % % NN cord-010119-t1x9gknd 1499 18 in in IN cord-010119-t1x9gknd 1499 19 2016 2016 CD cord-010119-t1x9gknd 1499 20 to to IN cord-010119-t1x9gknd 1499 21 45.8 45.8 CD cord-010119-t1x9gknd 1499 22 % % NN cord-010119-t1x9gknd 1499 23 in in IN cord-010119-t1x9gknd 1499 24 2017 2017 CD cord-010119-t1x9gknd 1499 25 . . . cord-010119-t1x9gknd 1500 1 Conclusion conclusion NN cord-010119-t1x9gknd 1500 2 : : : cord-010119-t1x9gknd 1501 1 The the DT cord-010119-t1x9gknd 1501 2 strategy strategy NN cord-010119-t1x9gknd 1501 3 was be VBD cord-010119-t1x9gknd 1501 4 more more RBR cord-010119-t1x9gknd 1501 5 than than IN cord-010119-t1x9gknd 1501 6 successful successful JJ cord-010119-t1x9gknd 1501 7 , , , cord-010119-t1x9gknd 1501 8 and and CC cord-010119-t1x9gknd 1501 9 it -PRON- PRP cord-010119-t1x9gknd 1501 10 allowed allow VBD cord-010119-t1x9gknd 1501 11 the the DT cord-010119-t1x9gknd 1501 12 blood blood NN cord-010119-t1x9gknd 1501 13 center center NN cord-010119-t1x9gknd 1501 14 to to TO cord-010119-t1x9gknd 1501 15 build build VB cord-010119-t1x9gknd 1501 16 a a DT cord-010119-t1x9gknd 1501 17 blood blood NN cord-010119-t1x9gknd 1501 18 inventory inventory NN cord-010119-t1x9gknd 1501 19 large large JJ cord-010119-t1x9gknd 1501 20 enough enough RB cord-010119-t1x9gknd 1501 21 to to TO cord-010119-t1x9gknd 1501 22 avoid avoid VB cord-010119-t1x9gknd 1501 23 risks risk NNS cord-010119-t1x9gknd 1501 24 of of IN cord-010119-t1x9gknd 1501 25 shortage shortage NN cord-010119-t1x9gknd 1501 26 due due JJ cord-010119-t1x9gknd 1501 27 to to IN cord-010119-t1x9gknd 1501 28 mass mass JJ cord-010119-t1x9gknd 1501 29 vaccination vaccination NN cord-010119-t1x9gknd 1501 30 against against IN cord-010119-t1x9gknd 1501 31 YFV YFV NNP cord-010119-t1x9gknd 1501 32 . . . cord-010119-t1x9gknd 1502 1 dose dose JJ cord-010119-t1x9gknd 1502 2 loss loss NN cord-010119-t1x9gknd 1502 3 which which WDT cord-010119-t1x9gknd 1502 4 must must MD cord-010119-t1x9gknd 1502 5 be be VB cord-010119-t1x9gknd 1502 6 accommodated accommodate VBN cord-010119-t1x9gknd 1502 7 when when WRB cord-010119-t1x9gknd 1502 8 collecting collect VBG cord-010119-t1x9gknd 1502 9 plt plt NNP cord-010119-t1x9gknd 1502 10 donations donation NNS cord-010119-t1x9gknd 1502 11 to to TO cord-010119-t1x9gknd 1502 12 ensure ensure VB cord-010119-t1x9gknd 1502 13 the the DT cord-010119-t1x9gknd 1502 14 US US NNP cord-010119-t1x9gknd 1502 15 plt plt NNP cord-010119-t1x9gknd 1502 16 dose dose NN cord-010119-t1x9gknd 1502 17 of of IN cord-010119-t1x9gknd 1502 18 ! ! . cord-010119-t1x9gknd 1503 1 3.0x10 3.0x10 CD cord-010119-t1x9gknd 1503 2 11 11 CD cord-010119-t1x9gknd 1503 3 is be VBZ cord-010119-t1x9gknd 1503 4 met meet VBN cord-010119-t1x9gknd 1503 5 . . . cord-010119-t1x9gknd 1504 1 Currently currently RB cord-010119-t1x9gknd 1504 2 , , , cord-010119-t1x9gknd 1504 3 Triple Triple NNP cord-010119-t1x9gknd 1504 4 Set Set NNP cord-010119-t1x9gknd 1504 5 kits kit NNS cord-010119-t1x9gknd 1504 6 for for IN cord-010119-t1x9gknd 1504 7 PR PR NNP cord-010119-t1x9gknd 1504 8 are be VBP cord-010119-t1x9gknd 1504 9 only only RB cord-010119-t1x9gknd 1504 10 approved approve VBN cord-010119-t1x9gknd 1504 11 in in IN cord-010119-t1x9gknd 1504 12 Europe Europe NNP cord-010119-t1x9gknd 1504 13 . . . cord-010119-t1x9gknd 1505 1 Plt Plt NNP cord-010119-t1x9gknd 1505 2 loss loss NN cord-010119-t1x9gknd 1505 3 , , , cord-010119-t1x9gknd 1505 4 and and CC cord-010119-t1x9gknd 1505 5 adjusted adjusted JJ cord-010119-t1x9gknd 1505 6 apheresis apheresis NN cord-010119-t1x9gknd 1505 7 targeting target VBG cord-010119-t1x9gknd 1505 8 parameters parameter NNS cord-010119-t1x9gknd 1505 9 may may MD cord-010119-t1x9gknd 1505 10 impact impact VB cord-010119-t1x9gknd 1505 11 split split NN cord-010119-t1x9gknd 1505 12 rate rate NN cord-010119-t1x9gknd 1505 13 ( ( -LRB- cord-010119-t1x9gknd 1505 14 SR SR NNP cord-010119-t1x9gknd 1505 15 ) ) -RRB- cord-010119-t1x9gknd 1505 16 or or CC cord-010119-t1x9gknd 1505 17 products product NNS cord-010119-t1x9gknd 1505 18 per per IN cord-010119-t1x9gknd 1505 19 apheresis apheresis NN cord-010119-t1x9gknd 1505 20 procedure procedure NN cord-010119-t1x9gknd 1505 21 . . . cord-010119-t1x9gknd 1506 1 Inventory inventory NN cord-010119-t1x9gknd 1506 2 suitable suitable JJ cord-010119-t1x9gknd 1506 3 for for IN cord-010119-t1x9gknd 1506 4 PR PR NNP cord-010119-t1x9gknd 1506 5 without without IN cord-010119-t1x9gknd 1506 6 impacting impact VBG cord-010119-t1x9gknd 1506 7 US US NNP cord-010119-t1x9gknd 1506 8 blood blood NN cord-010119-t1x9gknd 1506 9 center center NN cord-010119-t1x9gknd 1506 10 SRs SRs NNP cord-010119-t1x9gknd 1506 11 warrants warrant NNS cord-010119-t1x9gknd 1506 12 evaluation evaluation NN cord-010119-t1x9gknd 1506 13 and and CC cord-010119-t1x9gknd 1506 14 optimization optimization NN cord-010119-t1x9gknd 1506 15 . . . cord-010119-t1x9gknd 1507 1 Study Study NNP cord-010119-t1x9gknd 1507 2 Design Design NNP cord-010119-t1x9gknd 1507 3 / / SYM cord-010119-t1x9gknd 1507 4 Method method NN cord-010119-t1x9gknd 1507 5 : : : cord-010119-t1x9gknd 1507 6 1,000 1,000 CD cord-010119-t1x9gknd 1507 7 apheresis apheresis NN cord-010119-t1x9gknd 1507 8 collections collection NNS cord-010119-t1x9gknd 1507 9 from from IN cord-010119-t1x9gknd 1507 10 4 4 CD cord-010119-t1x9gknd 1507 11 centers center NNS cord-010119-t1x9gknd 1507 12 with with IN cord-010119-t1x9gknd 1507 13 different different JJ cord-010119-t1x9gknd 1507 14 SRs sr NNS cord-010119-t1x9gknd 1507 15 were be VBD cord-010119-t1x9gknd 1507 16 analyzed analyze VBN cord-010119-t1x9gknd 1507 17 . . . cord-010119-t1x9gknd 1508 1 A a DT cord-010119-t1x9gknd 1508 2 baseline baseline JJ cord-010119-t1x9gknd 1508 3 SR SR NNP cord-010119-t1x9gknd 1508 4 for for IN cord-010119-t1x9gknd 1508 5 conventional conventional JJ cord-010119-t1x9gknd 1508 6 PC pc NN cord-010119-t1x9gknd 1508 7 was be VBD cord-010119-t1x9gknd 1508 8 calculated calculate VBN cord-010119-t1x9gknd 1508 9 assuming assume VBG cord-010119-t1x9gknd 1508 10 i i PRP cord-010119-t1x9gknd 1508 11 ) ) -RRB- cord-010119-t1x9gknd 1508 12 a a DT cord-010119-t1x9gknd 1508 13 minimum minimum NN cord-010119-t1x9gknd 1508 14 dose dose NN cord-010119-t1x9gknd 1508 15 ( ( -LRB- cord-010119-t1x9gknd 1508 16 allowing allow VBG cord-010119-t1x9gknd 1508 17 for for IN cord-010119-t1x9gknd 1508 18 production production NN cord-010119-t1x9gknd 1508 19 loss loss NN cord-010119-t1x9gknd 1508 20 ) ) -RRB- cord-010119-t1x9gknd 1508 21 of of IN cord-010119-t1x9gknd 1508 22 3.1 3.1 CD cord-010119-t1x9gknd 1508 23 x10 x10 CD cord-010119-t1x9gknd 1508 24 11 11 CD cord-010119-t1x9gknd 1508 25 for for IN cord-010119-t1x9gknd 1508 26 single single JJ cord-010119-t1x9gknd 1508 27 ( ( -LRB- cord-010119-t1x9gknd 1508 28 S S NNP cord-010119-t1x9gknd 1508 29 ) ) -RRB- cord-010119-t1x9gknd 1508 30 , , , cord-010119-t1x9gknd 1508 31 6.3x1011 6.3x1011 NNP cord-010119-t1x9gknd 1508 32 11 11 CD cord-010119-t1x9gknd 1508 33 for for IN cord-010119-t1x9gknd 1508 34 double double JJ cord-010119-t1x9gknd 1508 35 ( ( -LRB- cord-010119-t1x9gknd 1508 36 D D NNP cord-010119-t1x9gknd 1508 37 ) ) -RRB- cord-010119-t1x9gknd 1508 38 , , , cord-010119-t1x9gknd 1508 39 and and CC cord-010119-t1x9gknd 1508 40 9.5x10 9.5x10 CD cord-010119-t1x9gknd 1508 41 11 11 CD cord-010119-t1x9gknd 1508 42 for for IN cord-010119-t1x9gknd 1508 43 triple triple JJ cord-010119-t1x9gknd 1508 44 ( ( -LRB- cord-010119-t1x9gknd 1508 45 T t NN cord-010119-t1x9gknd 1508 46 ) ) -RRB- cord-010119-t1x9gknd 1508 47 conventional conventional JJ cord-010119-t1x9gknd 1508 48 PCs pc NNS cord-010119-t1x9gknd 1508 49 , , , cord-010119-t1x9gknd 1508 50 ii ii LS cord-010119-t1x9gknd 1508 51 ) ) -RRB- cord-010119-t1x9gknd 1508 52 concentration concentration NN cord-010119-t1x9gknd 1508 53 and and CC cord-010119-t1x9gknd 1508 54 volume volume NN cord-010119-t1x9gknd 1508 55 requirements requirement NNS cord-010119-t1x9gknd 1508 56 from from IN cord-010119-t1x9gknd 1508 57 apheresis apheresis NN cord-010119-t1x9gknd 1508 58 device device NN cord-010119-t1x9gknd 1508 59 manufacturer manufacturer NN cord-010119-t1x9gknd 1508 60 were be VBD cord-010119-t1x9gknd 1508 61 used use VBN cord-010119-t1x9gknd 1508 62 . . . cord-010119-t1x9gknd 1509 1 For for IN cord-010119-t1x9gknd 1509 2 each each DT cord-010119-t1x9gknd 1509 3 collection collection NN cord-010119-t1x9gknd 1509 4 , , , cord-010119-t1x9gknd 1509 5 dose dose NN cord-010119-t1x9gknd 1509 6 , , , cord-010119-t1x9gknd 1509 7 volume volume NN cord-010119-t1x9gknd 1509 8 , , , cord-010119-t1x9gknd 1509 9 and and CC cord-010119-t1x9gknd 1509 10 concentration concentration NN cord-010119-t1x9gknd 1509 11 were be VBD cord-010119-t1x9gknd 1509 12 assessed assess VBN cord-010119-t1x9gknd 1509 13 for for IN cord-010119-t1x9gknd 1509 14 PR PR NNP cord-010119-t1x9gknd 1509 15 kit kit NN cord-010119-t1x9gknd 1509 16 compatibility compatibility NN cord-010119-t1x9gknd 1509 17 , , , cord-010119-t1x9gknd 1509 18 based base VBN cord-010119-t1x9gknd 1509 19 on on IN cord-010119-t1x9gknd 1509 20 storage storage NN cord-010119-t1x9gknd 1509 21 medium medium NN cord-010119-t1x9gknd 1509 22 ( ( -LRB- cord-010119-t1x9gknd 1509 23 PAS pas NN cord-010119-t1x9gknd 1509 24 or or CC cord-010119-t1x9gknd 1509 25 100 100 CD cord-010119-t1x9gknd 1509 26 % % NN cord-010119-t1x9gknd 1509 27 plasma plasma NN cord-010119-t1x9gknd 1509 28 ) ) -RRB- cord-010119-t1x9gknd 1509 29 assuming assume VBG cord-010119-t1x9gknd 1509 30 i i PRP cord-010119-t1x9gknd 1509 31 ) ) -RRB- cord-010119-t1x9gknd 1509 32 a a DT cord-010119-t1x9gknd 1509 33 minimum minimum NN cord-010119-t1x9gknd 1509 34 dose dose NN cord-010119-t1x9gknd 1509 35 ( ( -LRB- cord-010119-t1x9gknd 1509 36 allowing allow VBG cord-010119-t1x9gknd 1509 37 for for IN cord-010119-t1x9gknd 1509 38 production production NN cord-010119-t1x9gknd 1509 39 loss loss NN cord-010119-t1x9gknd 1509 40 ) ) -RRB- cord-010119-t1x9gknd 1509 41 of of IN cord-010119-t1x9gknd 1509 42 3.5 3.5 CD cord-010119-t1x9gknd 1509 43 x10 x10 CD cord-010119-t1x9gknd 1509 44 11 11 CD cord-010119-t1x9gknd 1509 45 for for IN cord-010119-t1x9gknd 1509 46 S S NNP cord-010119-t1x9gknd 1509 47 and and CC cord-010119-t1x9gknd 1509 48 6.7x10 6.7x10 CD cord-010119-t1x9gknd 1509 49 11 11 CD cord-010119-t1x9gknd 1509 50 for for IN cord-010119-t1x9gknd 1509 51 D d NN cord-010119-t1x9gknd 1509 52 for for IN cord-010119-t1x9gknd 1509 53 PR PR NNP cord-010119-t1x9gknd 1509 54 units unit NNS cord-010119-t1x9gknd 1509 55 , , , cord-010119-t1x9gknd 1509 56 ii ii LS cord-010119-t1x9gknd 1509 57 ) ) -RRB- cord-010119-t1x9gknd 1509 58 removing remove VBG cord-010119-t1x9gknd 1509 59 small small JJ cord-010119-t1x9gknd 1509 60 quantities quantity NNS cord-010119-t1x9gknd 1509 61 from from IN cord-010119-t1x9gknd 1509 62 units unit NNS cord-010119-t1x9gknd 1509 63 with with IN cord-010119-t1x9gknd 1509 64 excess excess JJ cord-010119-t1x9gknd 1509 65 volume volume NN cord-010119-t1x9gknd 1509 66 or or CC cord-010119-t1x9gknd 1509 67 dose dose NN cord-010119-t1x9gknd 1509 68 to to TO cord-010119-t1x9gknd 1509 69 meet meet VB cord-010119-t1x9gknd 1509 70 PR PR NNP cord-010119-t1x9gknd 1509 71 specs spec NNS cord-010119-t1x9gknd 1509 72 . . . cord-010119-t1x9gknd 1510 1 , , , cord-010119-t1x9gknd 1510 2 iii iii LS cord-010119-t1x9gknd 1510 3 ) ) -RRB- cord-010119-t1x9gknd 1510 4 if if IN cord-010119-t1x9gknd 1510 5 all all DT cord-010119-t1x9gknd 1510 6 or or CC cord-010119-t1x9gknd 1510 7 part part NN cord-010119-t1x9gknd 1510 8 of of IN cord-010119-t1x9gknd 1510 9 an an DT cord-010119-t1x9gknd 1510 10 out out NN cord-010119-t1x9gknd 1510 11 of of IN cord-010119-t1x9gknd 1510 12 parameter parameter NN cord-010119-t1x9gknd 1510 13 D d NN cord-010119-t1x9gknd 1510 14 or or CC cord-010119-t1x9gknd 1510 15 T t NN cord-010119-t1x9gknd 1510 16 collection collection NN cord-010119-t1x9gknd 1510 17 could could MD cord-010119-t1x9gknd 1510 18 be be VB cord-010119-t1x9gknd 1510 19 divided divide VBN cord-010119-t1x9gknd 1510 20 into into IN cord-010119-t1x9gknd 1510 21 one one CD cord-010119-t1x9gknd 1510 22 or or CC cord-010119-t1x9gknd 1510 23 more more JJR cord-010119-t1x9gknd 1510 24 kits kit NNS cord-010119-t1x9gknd 1510 25 for for IN cord-010119-t1x9gknd 1510 26 PR PR NNP cord-010119-t1x9gknd 1510 27 , , , cord-010119-t1x9gknd 1510 28 eligible eligible JJ cord-010119-t1x9gknd 1510 29 parts part NNS cord-010119-t1x9gknd 1510 30 undergo undergo VBP cord-010119-t1x9gknd 1510 31 PR PR NNP cord-010119-t1x9gknd 1510 32 , , , cord-010119-t1x9gknd 1510 33 and and CC cord-010119-t1x9gknd 1510 34 the the DT cord-010119-t1x9gknd 1510 35 remainder remainder NN cord-010119-t1x9gknd 1510 36 treated treat VBN cord-010119-t1x9gknd 1510 37 conventionally conventionally RB cord-010119-t1x9gknd 1510 38 , , , cord-010119-t1x9gknd 1510 39 iv iv LS cord-010119-t1x9gknd 1510 40 ) ) -RRB- cord-010119-t1x9gknd 1510 41 collections collection NNS cord-010119-t1x9gknd 1510 42 unsuitable unsuitable JJ cord-010119-t1x9gknd 1510 43 for for IN cord-010119-t1x9gknd 1510 44 PR PR NNP cord-010119-t1x9gknd 1510 45 specs spec NNS cord-010119-t1x9gknd 1510 46 . . . cord-010119-t1x9gknd 1511 1 or or CC cord-010119-t1x9gknd 1511 2 would would MD cord-010119-t1x9gknd 1511 3 decrease decrease VB cord-010119-t1x9gknd 1511 4 SR SR NNP cord-010119-t1x9gknd 1512 1 if if IN cord-010119-t1x9gknd 1512 2 treated treat VBN cord-010119-t1x9gknd 1512 3 would would MD cord-010119-t1x9gknd 1512 4 be be VB cord-010119-t1x9gknd 1512 5 counted count VBN cord-010119-t1x9gknd 1512 6 as as IN cord-010119-t1x9gknd 1512 7 conventional conventional JJ cord-010119-t1x9gknd 1512 8 PCs pc NNS cord-010119-t1x9gknd 1512 9 . . . cord-010119-t1x9gknd 1513 1 Results/ Results/ . cord-010119-t1x9gknd 1514 1 Finding finding NN cord-010119-t1x9gknd 1514 2 : : : cord-010119-t1x9gknd 1515 1 Conclusion conclusion NN cord-010119-t1x9gknd 1515 2 : : : cord-010119-t1x9gknd 1515 3 Blood blood NN cord-010119-t1x9gknd 1515 4 centers center NNS cord-010119-t1x9gknd 1515 5 today today NN cord-010119-t1x9gknd 1515 6 can can MD cord-010119-t1x9gknd 1515 7 adopt adopt VB cord-010119-t1x9gknd 1515 8 PR PR NNP cord-010119-t1x9gknd 1515 9 for for IN cord-010119-t1x9gknd 1515 10 a a DT cord-010119-t1x9gknd 1515 11 significant significant JJ cord-010119-t1x9gknd 1515 12 percent percent NN cord-010119-t1x9gknd 1515 13 of of IN cord-010119-t1x9gknd 1515 14 their -PRON- PRP$ cord-010119-t1x9gknd 1515 15 current current JJ cord-010119-t1x9gknd 1515 16 supply supply NN cord-010119-t1x9gknd 1515 17 ( ( -LRB- cord-010119-t1x9gknd 1515 18 as as RB cord-010119-t1x9gknd 1515 19 high high JJ cord-010119-t1x9gknd 1515 20 as as IN cord-010119-t1x9gknd 1515 21 99 99 CD cord-010119-t1x9gknd 1515 22 % % NN cord-010119-t1x9gknd 1515 23 ) ) -RRB- cord-010119-t1x9gknd 1515 24 without without IN cord-010119-t1x9gknd 1515 25 affecting affect VBG cord-010119-t1x9gknd 1515 26 their -PRON- PRP$ cord-010119-t1x9gknd 1515 27 SR SR NNP cord-010119-t1x9gknd 1515 28 . . . cord-010119-t1x9gknd 1516 1 Compatibly compatibly RB cord-010119-t1x9gknd 1516 2 increases increase VBZ cord-010119-t1x9gknd 1516 3 further further RB cord-010119-t1x9gknd 1516 4 by by IN cord-010119-t1x9gknd 1516 5 dividing divide VBG cord-010119-t1x9gknd 1516 6 T T NNP cord-010119-t1x9gknd 1516 7 and and CC cord-010119-t1x9gknd 1516 8 large large JJ cord-010119-t1x9gknd 1516 9 D d NN cord-010119-t1x9gknd 1516 10 donations donation NNS cord-010119-t1x9gknd 1516 11 . . . cord-010119-t1x9gknd 1517 1 Percent percent NN cord-010119-t1x9gknd 1517 2 achievable achievable JJ cord-010119-t1x9gknd 1517 3 depends depend VBZ cord-010119-t1x9gknd 1517 4 on on IN cord-010119-t1x9gknd 1517 5 their -PRON- PRP$ cord-010119-t1x9gknd 1517 6 current current JJ cord-010119-t1x9gknd 1517 7 S S NNP cord-010119-t1x9gknd 1517 8 , , , cord-010119-t1x9gknd 1517 9 D D NNP cord-010119-t1x9gknd 1517 10 , , , cord-010119-t1x9gknd 1517 11 T t NN cord-010119-t1x9gknd 1517 12 proportion proportion NN cord-010119-t1x9gknd 1517 13 of of IN cord-010119-t1x9gknd 1517 14 collections collection NNS cord-010119-t1x9gknd 1517 15 and and CC cord-010119-t1x9gknd 1517 16 practices practice NNS cord-010119-t1x9gknd 1517 17 . . . cord-010119-t1x9gknd 1518 1 Changes change NNS cord-010119-t1x9gknd 1518 2 to to IN cord-010119-t1x9gknd 1518 3 D D NNP cord-010119-t1x9gknd 1518 4 and and CC cord-010119-t1x9gknd 1518 5 T t NN cord-010119-t1x9gknd 1518 6 collection collection NN cord-010119-t1x9gknd 1518 7 parameters parameter NNS cord-010119-t1x9gknd 1518 8 , , , cord-010119-t1x9gknd 1518 9 optimized optimize VBN cord-010119-t1x9gknd 1518 10 donation donation NN cord-010119-t1x9gknd 1518 11 and and CC cord-010119-t1x9gknd 1518 12 counting counting NN cord-010119-t1x9gknd 1518 13 accuracy accuracy NN cord-010119-t1x9gknd 1518 14 , , , cord-010119-t1x9gknd 1518 15 and and CC cord-010119-t1x9gknd 1518 16 volume volume NN cord-010119-t1x9gknd 1518 17 reduction reduction NN cord-010119-t1x9gknd 1518 18 will will MD cord-010119-t1x9gknd 1518 19 improve improve VB cord-010119-t1x9gknd 1518 20 PR PR NNP cord-010119-t1x9gknd 1518 21 compatibility compatibility NN cord-010119-t1x9gknd 1518 22 further further RB cord-010119-t1x9gknd 1518 23 . . . cord-010119-t1x9gknd 1519 1 Individual individual JJ cord-010119-t1x9gknd 1519 2 analysis analysis NN cord-010119-t1x9gknd 1519 3 is be VBZ cord-010119-t1x9gknd 1519 4 warranted warrant VBN cord-010119-t1x9gknd 1519 5 for for IN cord-010119-t1x9gknd 1519 6 each each DT cord-010119-t1x9gknd 1519 7 blood blood NN cord-010119-t1x9gknd 1519 8 center center NN cord-010119-t1x9gknd 1519 9 . . . cord-010119-t1x9gknd 1520 1 RBC RBC NNP cord-010119-t1x9gknd 1520 2 _SP cord-010119-t1x9gknd 1520 3 2RBC 2RBC NNP cord-010119-t1x9gknd 1520 4 _SP cord-010119-t1x9gknd 1521 1 PLT PLT NNP cord-010119-t1x9gknd 1521 2 / / SYM cord-010119-t1x9gknd 1521 3 P p NN cord-010119-t1x9gknd 1521 4 _SP cord-010119-t1x9gknd 1521 5 PLT PLT NNP cord-010119-t1x9gknd 1521 6 _SP cord-010119-t1x9gknd 1521 7 PLT PLT NNP cord-010119-t1x9gknd 1521 8 / / SYM cord-010119-t1x9gknd 1521 9 RBC RBC NNP cord-010119-t1x9gknd 1521 10 / / SYM cord-010119-t1x9gknd 1521 11 P P NNP cord-010119-t1x9gknd 1521 12 _SP cord-010119-t1x9gknd 1521 13 PLT PLT NNP cord-010119-t1x9gknd 1521 14 / / SYM cord-010119-t1x9gknd 1521 15 RBC RBC NNP cord-010119-t1x9gknd 1521 16 _SP cord-010119-t1x9gknd 1522 1 2PLT 2PLT NNP cord-010119-t1x9gknd 1522 2 _SP cord-010119-t1x9gknd 1523 1 2PLT 2plt CD cord-010119-t1x9gknd 1524 1 / / NFP cord-010119-t1x9gknd 1525 1 RBC RBC NNP cord-010119-t1x9gknd 1525 2 _SP cord-010119-t1x9gknd 1525 3 2PLT 2plt CD cord-010119-t1x9gknd 1526 1 /P /P NNP cord-010119-t1x9gknd 1526 2 _SP cord-010119-t1x9gknd 1526 3 # # NN cord-010119-t1x9gknd 1526 4 donations donation NNS cord-010119-t1x9gknd 1526 5 _SP cord-010119-t1x9gknd 1526 6 47990 47990 CD cord-010119-t1x9gknd 1526 7 _SP cord-010119-t1x9gknd 1527 1 63 63 CD cord-010119-t1x9gknd 1527 2 _SP cord-010119-t1x9gknd 1527 3 1775 1775 CD cord-010119-t1x9gknd 1527 4 _SP cord-010119-t1x9gknd 1528 1 10832 10832 CD cord-010119-t1x9gknd 1528 2 _SP cord-010119-t1x9gknd 1529 1 968 968 CD cord-010119-t1x9gknd 1529 2 _SP cord-010119-t1x9gknd 1530 1 476 476 CD cord-010119-t1x9gknd 1530 2 _SP cord-010119-t1x9gknd 1531 1 67 67 CD cord-010119-t1x9gknd 1531 2 _SP cord-010119-t1x9gknd 1532 1 1150 1150 CD cord-010119-t1x9gknd 1532 2 _SP cord-010119-t1x9gknd 1533 1 142 142 CD cord-010119-t1x9gknd 1533 2 _SP cord-010119-t1x9gknd 1534 1 10252 10252 CD cord-010119-t1x9gknd 1534 2 _SP cord-010119-t1x9gknd 1535 1 Citrate Citrate NNP cord-010119-t1x9gknd 1535 2 exposure exposure NN cord-010119-t1x9gknd 1535 3 ( ( -LRB- cord-010119-t1x9gknd 1535 4 mls mls NNP cord-010119-t1x9gknd 1535 5 ) ) -RRB- cord-010119-t1x9gknd 1535 6 _SP cord-010119-t1x9gknd 1536 1 41 41 CD cord-010119-t1x9gknd 1536 2 - - SYM cord-010119-t1x9gknd 1536 3 85 85 CD cord-010119-t1x9gknd 1536 4 _SP cord-010119-t1x9gknd 1536 5 71 71 CD cord-010119-t1x9gknd 1536 6 _SP cord-010119-t1x9gknd 1537 1 138 138 CD cord-010119-t1x9gknd 1537 2 _SP cord-010119-t1x9gknd 1538 1 263 263 CD cord-010119-t1x9gknd 1538 2 _SP cord-010119-t1x9gknd 1539 1 266 266 CD cord-010119-t1x9gknd 1539 2 _SP cord-010119-t1x9gknd 1540 1 300 300 CD cord-010119-t1x9gknd 1540 2 _SP cord-010119-t1x9gknd 1540 3 322 322 CD cord-010119-t1x9gknd 1540 4 _SP cord-010119-t1x9gknd 1541 1 349 349 CD cord-010119-t1x9gknd 1541 2 _SP cord-010119-t1x9gknd 1541 3 478 478 CD cord-010119-t1x9gknd 1541 4 Study Study NNP cord-010119-t1x9gknd 1541 5 Design Design NNP cord-010119-t1x9gknd 1541 6 / / SYM cord-010119-t1x9gknd 1541 7 Method method NN cord-010119-t1x9gknd 1541 8 : : : cord-010119-t1x9gknd 1542 1 A a DT cord-010119-t1x9gknd 1542 2 randomized randomized JJ cord-010119-t1x9gknd 1542 3 ( ( -LRB- cord-010119-t1x9gknd 1542 4 2:1 2:1 CD cord-010119-t1x9gknd 1542 5 ) ) -RRB- cord-010119-t1x9gknd 1542 6 , , , cord-010119-t1x9gknd 1542 7 placebo placebo NN cord-010119-t1x9gknd 1542 8 - - HYPH cord-010119-t1x9gknd 1542 9 controlled control VBN cord-010119-t1x9gknd 1542 10 , , , cord-010119-t1x9gknd 1542 11 single single JJ cord-010119-t1x9gknd 1542 12 blind blind JJ cord-010119-t1x9gknd 1542 13 , , , cord-010119-t1x9gknd 1542 14 15 15 CD cord-010119-t1x9gknd 1542 15 subject subject NN cord-010119-t1x9gknd 1542 16 , , , cord-010119-t1x9gknd 1542 17 single single JJ cord-010119-t1x9gknd 1542 18 - - HYPH cord-010119-t1x9gknd 1542 19 site site NN cord-010119-t1x9gknd 1542 20 study study NN cord-010119-t1x9gknd 1542 21 of of IN cord-010119-t1x9gknd 1542 22 ascending ascend VBG cord-010119-t1x9gknd 1542 23 microdoses microdose NNS cord-010119-t1x9gknd 1542 24 of of IN cord-010119-t1x9gknd 1542 25 autologous autologous JJ cord-010119-t1x9gknd 1542 26 ( ( -LRB- cord-010119-t1x9gknd 1542 27 apheresis apheresis NN cord-010119-t1x9gknd 1542 28 - - HYPH cord-010119-t1x9gknd 1542 29 derived derive VBN cord-010119-t1x9gknd 1542 30 ) ) -RRB- cord-010119-t1x9gknd 1543 1 Thrombosomes Thrombosomes NNP cord-010119-t1x9gknd 1543 2 was be VBD cord-010119-t1x9gknd 1543 3 conducted conduct VBN cord-010119-t1x9gknd 1543 4 . . . cord-010119-t1x9gknd 1544 1 Subjects subject NNS cord-010119-t1x9gknd 1544 2 were be VBD cord-010119-t1x9gknd 1544 3 divided divide VBN cord-010119-t1x9gknd 1544 4 into into IN cord-010119-t1x9gknd 1544 5 5 5 CD cord-010119-t1x9gknd 1544 6 cohorts cohort NNS cord-010119-t1x9gknd 1544 7 , , , cord-010119-t1x9gknd 1544 8 receiving receive VBG cord-010119-t1x9gknd 1544 9 increasing increase VBG cord-010119-t1x9gknd 1544 10 doses dose NNS cord-010119-t1x9gknd 1544 11 , , , cord-010119-t1x9gknd 1544 12 ranging range VBG cord-010119-t1x9gknd 1544 13 from from IN cord-010119-t1x9gknd 1544 14 1/1,000 1/1,000 CD cord-010119-t1x9gknd 1544 15 -1/10 -1/10 NN cord-010119-t1x9gknd 1544 16 of of IN cord-010119-t1x9gknd 1544 17 the the DT cord-010119-t1x9gknd 1544 18 lowest low JJS cord-010119-t1x9gknd 1544 19 effective effective JJ cord-010119-t1x9gknd 1544 20 dose dose NN cord-010119-t1x9gknd 1544 21 found find VBN cord-010119-t1x9gknd 1544 22 in in IN cord-010119-t1x9gknd 1544 23 the the DT cord-010119-t1x9gknd 1544 24 above above JJ cord-010119-t1x9gknd 1544 25 rabbit rabbit NN cord-010119-t1x9gknd 1544 26 model model NN cord-010119-t1x9gknd 1544 27 . . . cord-010119-t1x9gknd 1545 1 Cohorts cohort NNS cord-010119-t1x9gknd 1545 2 4 4 CD cord-010119-t1x9gknd 1545 3 and and CC cord-010119-t1x9gknd 1545 4 5 5 CD cord-010119-t1x9gknd 1545 5 received receive VBD cord-010119-t1x9gknd 1545 6 the the DT cord-010119-t1x9gknd 1545 7 1/10th 1/10th CD cord-010119-t1x9gknd 1545 8 dose dose NN cord-010119-t1x9gknd 1545 9 , , , cord-010119-t1x9gknd 1545 10 but but CC cord-010119-t1x9gknd 1545 11 cohort cohort NN cord-010119-t1x9gknd 1545 12 5 5 CD cord-010119-t1x9gknd 1545 13 received receive VBD cord-010119-t1x9gknd 1545 14 two two CD cord-010119-t1x9gknd 1545 15 1/20th 1/20th CD cord-010119-t1x9gknd 1545 16 doses dose NNS cord-010119-t1x9gknd 1545 17 one one CD cord-010119-t1x9gknd 1545 18 hour hour NN cord-010119-t1x9gknd 1545 19 apart apart RB cord-010119-t1x9gknd 1545 20 . . . cord-010119-t1x9gknd 1546 1 The the DT cord-010119-t1x9gknd 1546 2 primary primary JJ cord-010119-t1x9gknd 1546 3 end end NN cord-010119-t1x9gknd 1546 4 points point NNS cord-010119-t1x9gknd 1546 5 were be VBD cord-010119-t1x9gknd 1546 6 safety safety NN cord-010119-t1x9gknd 1546 7 and and CC cord-010119-t1x9gknd 1546 8 tolerability tolerability NN cord-010119-t1x9gknd 1546 9 . . . cord-010119-t1x9gknd 1547 1 Subjects subject NNS cord-010119-t1x9gknd 1547 2 were be VBD cord-010119-t1x9gknd 1547 3 monitored monitor VBN cord-010119-t1x9gknd 1547 4 in in IN cord-010119-t1x9gknd 1547 5 - - HYPH cord-010119-t1x9gknd 1547 6 hospital hospital NN cord-010119-t1x9gknd 1547 7 for for IN cord-010119-t1x9gknd 1547 8 24hrs 24hrs NNP cord-010119-t1x9gknd 1547 9 post post NN cord-010119-t1x9gknd 1547 10 infusion infusion NN cord-010119-t1x9gknd 1547 11 and and CC cord-010119-t1x9gknd 1547 12 followed follow VBD cord-010119-t1x9gknd 1547 13 for for IN cord-010119-t1x9gknd 1547 14 up up IN cord-010119-t1x9gknd 1547 15 to to TO cord-010119-t1x9gknd 1547 16 60 60 CD cord-010119-t1x9gknd 1547 17 days day NNS cord-010119-t1x9gknd 1547 18 for for IN cord-010119-t1x9gknd 1547 19 adverse adverse JJ cord-010119-t1x9gknd 1547 20 events event NNS cord-010119-t1x9gknd 1547 21 , , , cord-010119-t1x9gknd 1547 22 global global JJ cord-010119-t1x9gknd 1547 23 neurological neurological JJ cord-010119-t1x9gknd 1547 24 assessments assessment NNS cord-010119-t1x9gknd 1547 25 , , , cord-010119-t1x9gknd 1547 26 abbreviated abbreviate VBN cord-010119-t1x9gknd 1547 27 physical physical JJ cord-010119-t1x9gknd 1547 28 exams exam NNS cord-010119-t1x9gknd 1547 29 , , , cord-010119-t1x9gknd 1547 30 and and CC cord-010119-t1x9gknd 1547 31 laboratory laboratory NN cord-010119-t1x9gknd 1547 32 tests test NNS cord-010119-t1x9gknd 1547 33 . . . cord-010119-t1x9gknd 1548 1 Results result NNS cord-010119-t1x9gknd 1548 2 / / SYM cord-010119-t1x9gknd 1548 3 Findings finding NNS cord-010119-t1x9gknd 1549 1 : : : cord-010119-t1x9gknd 1549 2 There there EX cord-010119-t1x9gknd 1549 3 were be VBD cord-010119-t1x9gknd 1549 4 no no DT cord-010119-t1x9gknd 1549 5 serious serious JJ cord-010119-t1x9gknd 1549 6 adverse adverse JJ cord-010119-t1x9gknd 1549 7 events event NNS cord-010119-t1x9gknd 1549 8 ( ( -LRB- cord-010119-t1x9gknd 1549 9 SAEs SAEs NNP cord-010119-t1x9gknd 1549 10 ) ) -RRB- cord-010119-t1x9gknd 1549 11 or or CC cord-010119-t1x9gknd 1549 12 subject subject JJ cord-010119-t1x9gknd 1549 13 discontinuation discontinuation NN cord-010119-t1x9gknd 1549 14 post post NN cord-010119-t1x9gknd 1549 15 - - NN cord-010119-t1x9gknd 1549 16 infusion infusion NN cord-010119-t1x9gknd 1549 17 due due IN cord-010119-t1x9gknd 1549 18 to to IN cord-010119-t1x9gknd 1549 19 a a DT cord-010119-t1x9gknd 1549 20 significant significant JJ cord-010119-t1x9gknd 1549 21 decrease decrease NN cord-010119-t1x9gknd 1549 22 in in IN cord-010119-t1x9gknd 1549 23 platelet platelet NN cord-010119-t1x9gknd 1549 24 count count NN cord-010119-t1x9gknd 1549 25 from from IN cord-010119-t1x9gknd 1549 26 baseline baseline NN cord-010119-t1x9gknd 1549 27 . . . cord-010119-t1x9gknd 1550 1 There there EX cord-010119-t1x9gknd 1550 2 were be VBD cord-010119-t1x9gknd 1550 3 a a DT cord-010119-t1x9gknd 1550 4 total total NN cord-010119-t1x9gknd 1550 5 of of IN cord-010119-t1x9gknd 1550 6 68 68 CD cord-010119-t1x9gknd 1550 7 AEs ae NNS cord-010119-t1x9gknd 1550 8 : : : cord-010119-t1x9gknd 1550 9 40 40 CD cord-010119-t1x9gknd 1550 10 were be VBD cord-010119-t1x9gknd 1550 11 treatment treatment NN cord-010119-t1x9gknd 1550 12 emergent emergent JJ cord-010119-t1x9gknd 1550 13 ( ( -LRB- cord-010119-t1x9gknd 1550 14 TEAE TEAE NNP cord-010119-t1x9gknd 1550 15 ) ) -RRB- cord-010119-t1x9gknd 1550 16 , , , cord-010119-t1x9gknd 1550 17 of of IN cord-010119-t1x9gknd 1550 18 which which WDT cord-010119-t1x9gknd 1550 19 8 8 CD cord-010119-t1x9gknd 1550 20 were be VBD cord-010119-t1x9gknd 1550 21 treatment treatment NN cord-010119-t1x9gknd 1550 22 - - HYPH cord-010119-t1x9gknd 1550 23 related relate VBN cord-010119-t1x9gknd 1550 24 ( ( -LRB- cord-010119-t1x9gknd 1550 25 6 6 CD cord-010119-t1x9gknd 1550 26 Thrombosomes Thrombosomes NNPS cord-010119-t1x9gknd 1550 27 and and CC cord-010119-t1x9gknd 1550 28 2 2 CD cord-010119-t1x9gknd 1550 29 Control Control NNP cord-010119-t1x9gknd 1550 30 ) ) -RRB- cord-010119-t1x9gknd 1550 31 . . . cord-010119-t1x9gknd 1551 1 All all DT cord-010119-t1x9gknd 1551 2 TEAEs teae NNS cord-010119-t1x9gknd 1551 3 were be VBD cord-010119-t1x9gknd 1551 4 mild mild JJ cord-010119-t1x9gknd 1551 5 or or CC cord-010119-t1x9gknd 1551 6 moderate moderate JJ cord-010119-t1x9gknd 1551 7 in in IN cord-010119-t1x9gknd 1551 8 severity severity NN cord-010119-t1x9gknd 1551 9 . . . cord-010119-t1x9gknd 1552 1 In in IN cord-010119-t1x9gknd 1552 2 cohorts cohort NNS cord-010119-t1x9gknd 1552 3 4 4 CD cord-010119-t1x9gknd 1552 4 and and CC cord-010119-t1x9gknd 1552 5 5 5 CD cord-010119-t1x9gknd 1552 6 , , , cord-010119-t1x9gknd 1552 7 3/4 3/4 CD cord-010119-t1x9gknd 1552 8 Thrombosomes Thrombosomes NNP cord-010119-t1x9gknd 1552 9 subjects subject NNS cord-010119-t1x9gknd 1552 10 had have VBD cord-010119-t1x9gknd 1552 11 treatment treatment NN cord-010119-t1x9gknd 1552 12 related relate VBN cord-010119-t1x9gknd 1552 13 adverse adverse JJ cord-010119-t1x9gknd 1552 14 events event NNS cord-010119-t1x9gknd 1552 15 . . . cord-010119-t1x9gknd 1553 1 One one CD cord-010119-t1x9gknd 1553 2 cohort cohort NN cord-010119-t1x9gknd 1553 3 4 4 CD cord-010119-t1x9gknd 1553 4 subject subject NN cord-010119-t1x9gknd 1553 5 developed develop VBD cord-010119-t1x9gknd 1553 6 an an DT cord-010119-t1x9gknd 1553 7 upper upper JJ cord-010119-t1x9gknd 1553 8 respiratory respiratory JJ cord-010119-t1x9gknd 1553 9 infection infection NN cord-010119-t1x9gknd 1553 10 and and CC cord-010119-t1x9gknd 1553 11 elevated elevated JJ cord-010119-t1x9gknd 1553 12 WBCs wbc NNS cord-010119-t1x9gknd 1553 13 within within IN cord-010119-t1x9gknd 1553 14 8 8 CD cord-010119-t1x9gknd 1553 15 hours hour NNS cord-010119-t1x9gknd 1553 16 post post NN cord-010119-t1x9gknd 1553 17 infusion infusion NN cord-010119-t1x9gknd 1553 18 , , , cord-010119-t1x9gknd 1553 19 which which WDT cord-010119-t1x9gknd 1553 20 resolved resolve VBN cord-010119-t1x9gknd 1553 21 by by IN cord-010119-t1x9gknd 1553 22 24 24 CD cord-010119-t1x9gknd 1553 23 hours hour NNS cord-010119-t1x9gknd 1553 24 , , , cord-010119-t1x9gknd 1553 25 and and CC cord-010119-t1x9gknd 1553 26 an an DT cord-010119-t1x9gknd 1553 27 elevated elevated JJ cord-010119-t1x9gknd 1553 28 D d NN cord-010119-t1x9gknd 1553 29 - - HYPH cord-010119-t1x9gknd 1553 30 dimer dimer NN cord-010119-t1x9gknd 1553 31 at at IN cord-010119-t1x9gknd 1553 32 24 24 CD cord-010119-t1x9gknd 1553 33 hours hour NNS cord-010119-t1x9gknd 1553 34 post post NN cord-010119-t1x9gknd 1553 35 infusion infusion NN cord-010119-t1x9gknd 1553 36 , , , cord-010119-t1x9gknd 1553 37 which which WDT cord-010119-t1x9gknd 1553 38 resolved resolve VBN cord-010119-t1x9gknd 1553 39 by by IN cord-010119-t1x9gknd 1553 40 Day Day NNP cord-010119-t1x9gknd 1553 41 7 7 CD cord-010119-t1x9gknd 1553 42 . . . cord-010119-t1x9gknd 1554 1 This this DT cord-010119-t1x9gknd 1554 2 subject subject NN cord-010119-t1x9gknd 1554 3 also also RB cord-010119-t1x9gknd 1554 4 had have VBD cord-010119-t1x9gknd 1554 5 an an DT cord-010119-t1x9gknd 1554 6 elevation elevation NN cord-010119-t1x9gknd 1554 7 of of IN cord-010119-t1x9gknd 1554 8 Prothrombin Prothrombin NNP cord-010119-t1x9gknd 1554 9 Fragment Fragment NNP cord-010119-t1x9gknd 1554 10 1 1 CD cord-010119-t1x9gknd 1554 11 1 1 CD cord-010119-t1x9gknd 1554 12 2 2 CD cord-010119-t1x9gknd 1554 13 at at IN cord-010119-t1x9gknd 1554 14 baseline baseline NN cord-010119-t1x9gknd 1554 15 , , , cord-010119-t1x9gknd 1554 16 which which WDT cord-010119-t1x9gknd 1554 17 increased increase VBD cord-010119-t1x9gknd 1554 18 post post NN cord-010119-t1x9gknd 1554 19 transfusion transfusion NN cord-010119-t1x9gknd 1554 20 and and CC cord-010119-t1x9gknd 1554 21 peaked peak VBD cord-010119-t1x9gknd 1554 22 at at IN cord-010119-t1x9gknd 1554 23 24 24 CD cord-010119-t1x9gknd 1554 24 hours hour NNS cord-010119-t1x9gknd 1554 25 with with IN cord-010119-t1x9gknd 1554 26 resolution resolution NN cord-010119-t1x9gknd 1554 27 by by IN cord-010119-t1x9gknd 1554 28 Day Day NNP cord-010119-t1x9gknd 1554 29 14 14 CD cord-010119-t1x9gknd 1554 30 . . . cord-010119-t1x9gknd 1555 1 One one CD cord-010119-t1x9gknd 1555 2 cohort cohort NN cord-010119-t1x9gknd 1555 3 5 5 CD cord-010119-t1x9gknd 1555 4 subject subject NN cord-010119-t1x9gknd 1555 5 developed develop VBN cord-010119-t1x9gknd 1555 6 non non JJ cord-010119-t1x9gknd 1555 7 - - JJ cord-010119-t1x9gknd 1555 8 specific specific JJ cord-010119-t1x9gknd 1555 9 T t NN cord-010119-t1x9gknd 1555 10 - - HYPH cord-010119-t1x9gknd 1555 11 wave wave NN cord-010119-t1x9gknd 1555 12 changes change NNS cord-010119-t1x9gknd 1555 13 at at IN cord-010119-t1x9gknd 1555 14 1 1 CD cord-010119-t1x9gknd 1555 15 and and CC cord-010119-t1x9gknd 1555 16 2 2 CD cord-010119-t1x9gknd 1555 17 hours hour NNS cord-010119-t1x9gknd 1555 18 following follow VBG cord-010119-t1x9gknd 1555 19 her -PRON- PRP$ cord-010119-t1x9gknd 1555 20 2nd 2nd JJ cord-010119-t1x9gknd 1555 21 infusion infusion NN cord-010119-t1x9gknd 1555 22 that that WDT cord-010119-t1x9gknd 1555 23 resolved resolve VBN cord-010119-t1x9gknd 1555 24 by by IN cord-010119-t1x9gknd 1555 25 Day Day NNP cord-010119-t1x9gknd 1555 26 21 21 CD cord-010119-t1x9gknd 1555 27 without without IN cord-010119-t1x9gknd 1555 28 clinical clinical JJ cord-010119-t1x9gknd 1555 29 symptoms symptom NNS cord-010119-t1x9gknd 1555 30 . . . cord-010119-t1x9gknd 1556 1 Troponin troponin JJ cord-010119-t1x9gknd 1556 2 levels level NNS cord-010119-t1x9gknd 1556 3 and and CC cord-010119-t1x9gknd 1556 4 ECHO echo NN cord-010119-t1x9gknd 1556 5 stress stress NN cord-010119-t1x9gknd 1556 6 tests test NNS cord-010119-t1x9gknd 1556 7 were be VBD cord-010119-t1x9gknd 1556 8 normal normal JJ cord-010119-t1x9gknd 1556 9 . . . cord-010119-t1x9gknd 1557 1 EKGs ekg NNS cord-010119-t1x9gknd 1557 2 were be VBD cord-010119-t1x9gknd 1557 3 considered consider VBN cord-010119-t1x9gknd 1557 4 possibly possibly RB cord-010119-t1x9gknd 1557 5 a a DT cord-010119-t1x9gknd 1557 6 normal normal JJ cord-010119-t1x9gknd 1557 7 variant variant NN cord-010119-t1x9gknd 1557 8 or or CC cord-010119-t1x9gknd 1557 9 related relate VBN cord-010119-t1x9gknd 1557 10 to to IN cord-010119-t1x9gknd 1557 11 placement placement NN cord-010119-t1x9gknd 1557 12 of of IN cord-010119-t1x9gknd 1557 13 the the DT cord-010119-t1x9gknd 1557 14 EKG EKG NNP cord-010119-t1x9gknd 1557 15 leads lead VBZ cord-010119-t1x9gknd 1557 16 . . . cord-010119-t1x9gknd 1558 1 Another another DT cord-010119-t1x9gknd 1558 2 cohort cohort NN cord-010119-t1x9gknd 1558 3 5 5 CD cord-010119-t1x9gknd 1558 4 subject subject NN cord-010119-t1x9gknd 1558 5 developed develop VBD cord-010119-t1x9gknd 1558 6 an an DT cord-010119-t1x9gknd 1558 7 IgG IgG NNP cord-010119-t1x9gknd 1558 8 platelet platelet NN cord-010119-t1x9gknd 1558 9 autoantibody autoantibody NN cord-010119-t1x9gknd 1558 10 on on IN cord-010119-t1x9gknd 1558 11 Days Days NNP cord-010119-t1x9gknd 1558 12 7 7 CD cord-010119-t1x9gknd 1558 13 - - SYM cord-010119-t1x9gknd 1558 14 21 21 CD cord-010119-t1x9gknd 1558 15 , , , cord-010119-t1x9gknd 1558 16 which which WDT cord-010119-t1x9gknd 1558 17 was be VBD cord-010119-t1x9gknd 1558 18 undetectable undetectable JJ cord-010119-t1x9gknd 1558 19 on on IN cord-010119-t1x9gknd 1558 20 Days day NNS cord-010119-t1x9gknd 1558 21 42 42 CD cord-010119-t1x9gknd 1558 22 - - SYM cord-010119-t1x9gknd 1558 23 60 60 CD cord-010119-t1x9gknd 1558 24 ; ; : cord-010119-t1x9gknd 1558 25 there there EX cord-010119-t1x9gknd 1558 26 was be VBD cord-010119-t1x9gknd 1558 27 no no DT cord-010119-t1x9gknd 1558 28 change change NN cord-010119-t1x9gknd 1558 29 in in IN cord-010119-t1x9gknd 1558 30 platelet platelet NN cord-010119-t1x9gknd 1558 31 counts count NNS cord-010119-t1x9gknd 1558 32 . . . cord-010119-t1x9gknd 1559 1 The the DT cord-010119-t1x9gknd 1559 2 Thrombosomes Thrombosomes NNP cord-010119-t1x9gknd 1559 3 autoantibody autoantibody NN cord-010119-t1x9gknd 1559 4 assay assay NN cord-010119-t1x9gknd 1559 5 was be VBD cord-010119-t1x9gknd 1559 6 positive positive JJ cord-010119-t1x9gknd 1559 7 at at IN cord-010119-t1x9gknd 1559 8 baseline baseline NN cord-010119-t1x9gknd 1559 9 , , , cord-010119-t1x9gknd 1559 10 Days Days NNPS cord-010119-t1x9gknd 1559 11 7 7 CD cord-010119-t1x9gknd 1559 12 - - SYM cord-010119-t1x9gknd 1559 13 14 14 CD cord-010119-t1x9gknd 1559 14 , , , cord-010119-t1x9gknd 1559 15 and and CC cord-010119-t1x9gknd 1559 16 negative negative JJ cord-010119-t1x9gknd 1559 17 on on IN cord-010119-t1x9gknd 1559 18 Days day NNS cord-010119-t1x9gknd 1559 19 21 21 CD cord-010119-t1x9gknd 1559 20 - - SYM cord-010119-t1x9gknd 1559 21 60 60 CD cord-010119-t1x9gknd 1559 22 . . . cord-010119-t1x9gknd 1560 1 Background Background NNP cord-010119-t1x9gknd 1560 2 / / SYM cord-010119-t1x9gknd 1560 3 Case Case NNP cord-010119-t1x9gknd 1560 4 Studies Studies NNPS cord-010119-t1x9gknd 1560 5 : : : cord-010119-t1x9gknd 1561 1 Cryopreservation cryopreservation NN cord-010119-t1x9gknd 1561 2 of of IN cord-010119-t1x9gknd 1561 3 platelets platelet NNS cord-010119-t1x9gknd 1561 4 ( ( -LRB- cord-010119-t1x9gknd 1561 5 PLTs plt NNS cord-010119-t1x9gknd 1561 6 ) ) -RRB- cord-010119-t1x9gknd 1561 7 could could MD cord-010119-t1x9gknd 1561 8 extend extend VB cord-010119-t1x9gknd 1561 9 the the DT cord-010119-t1x9gknd 1561 10 shelf shelf NN cord-010119-t1x9gknd 1561 11 life life NN cord-010119-t1x9gknd 1561 12 from from IN cord-010119-t1x9gknd 1561 13 5 5 CD cord-010119-t1x9gknd 1561 14 - - SYM cord-010119-t1x9gknd 1561 15 7 7 CD cord-010119-t1x9gknd 1561 16 days day NNS cord-010119-t1x9gknd 1561 17 to to IN cord-010119-t1x9gknd 1561 18 over over IN cord-010119-t1x9gknd 1561 19 two two CD cord-010119-t1x9gknd 1561 20 years year NNS cord-010119-t1x9gknd 1561 21 . . . cord-010119-t1x9gknd 1562 1 Cryopreserved Cryopreserved NNP cord-010119-t1x9gknd 1562 2 PLTs PLTs NNP cord-010119-t1x9gknd 1562 3 ( ( -LRB- cord-010119-t1x9gknd 1562 4 CryoPLTs cryoplts NN cord-010119-t1x9gknd 1562 5 ) ) -RRB- cord-010119-t1x9gknd 1562 6 appear appear VBP cord-010119-t1x9gknd 1562 7 to to TO cord-010119-t1x9gknd 1562 8 have have VB cord-010119-t1x9gknd 1562 9 a a DT cord-010119-t1x9gknd 1562 10 greater great JJR cord-010119-t1x9gknd 1562 11 in in IN cord-010119-t1x9gknd 1562 12 vivo vivo NN cord-010119-t1x9gknd 1562 13 hemostatic hemostatic JJ cord-010119-t1x9gknd 1562 14 effect effect NN cord-010119-t1x9gknd 1562 15 than than IN cord-010119-t1x9gknd 1562 16 liquidstored liquidstored JJ cord-010119-t1x9gknd 1562 17 PLTs plt NNS cord-010119-t1x9gknd 1562 18 . . . cord-010119-t1x9gknd 1563 1 PLTs plt NNS cord-010119-t1x9gknd 1563 2 have have VBP cord-010119-t1x9gknd 1563 3 been be VBN cord-010119-t1x9gknd 1563 4 shown show VBN cord-010119-t1x9gknd 1563 5 to to TO cord-010119-t1x9gknd 1563 6 require require VB cord-010119-t1x9gknd 1563 7 protein protein NN cord-010119-t1x9gknd 1563 8 synthesis synthesis NN cord-010119-t1x9gknd 1563 9 capabilities capability NNS cord-010119-t1x9gknd 1563 10 for for IN cord-010119-t1x9gknd 1563 11 certain certain JJ cord-010119-t1x9gknd 1563 12 functions function NNS cord-010119-t1x9gknd 1563 13 such such JJ cord-010119-t1x9gknd 1563 14 as as IN cord-010119-t1x9gknd 1563 15 clot clot NN cord-010119-t1x9gknd 1563 16 signaling signaling NN cord-010119-t1x9gknd 1563 17 and and CC cord-010119-t1x9gknd 1563 18 immune immune JJ cord-010119-t1x9gknd 1563 19 responses response NNS cord-010119-t1x9gknd 1563 20 . . . cord-010119-t1x9gknd 1564 1 This this DT cord-010119-t1x9gknd 1564 2 study study NN cord-010119-t1x9gknd 1564 3 was be VBD cord-010119-t1x9gknd 1564 4 designed design VBN cord-010119-t1x9gknd 1564 5 to to TO cord-010119-t1x9gknd 1564 6 assess assess VB cord-010119-t1x9gknd 1564 7 whether whether IN cord-010119-t1x9gknd 1564 8 reconstituted reconstitute VBN cord-010119-t1x9gknd 1564 9 cryo cryo NN cord-010119-t1x9gknd 1564 10 - - HYPH cord-010119-t1x9gknd 1564 11 PLTs plt NNS cord-010119-t1x9gknd 1564 12 carry carry VBP cord-010119-t1x9gknd 1564 13 out out RP cord-010119-t1x9gknd 1564 14 protein protein NN cord-010119-t1x9gknd 1564 15 synthesis synthesis NN cord-010119-t1x9gknd 1564 16 upon upon IN cord-010119-t1x9gknd 1564 17 thawing thaw VBG cord-010119-t1x9gknd 1564 18 and and CC cord-010119-t1x9gknd 1564 19 short short JJ cord-010119-t1x9gknd 1564 20 term term NN cord-010119-t1x9gknd 1564 21 storage storage NN cord-010119-t1x9gknd 1564 22 . . . cord-010119-t1x9gknd 1565 1 Study Study NNP cord-010119-t1x9gknd 1565 2 Design Design NNP cord-010119-t1x9gknd 1565 3 / / SYM cord-010119-t1x9gknd 1565 4 Methods method NNS cord-010119-t1x9gknd 1565 5 : : : cord-010119-t1x9gknd 1565 6 Apheresis Apheresis NNP cord-010119-t1x9gknd 1565 7 PLTs plt NNS cord-010119-t1x9gknd 1565 8 were be VBD cord-010119-t1x9gknd 1565 9 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 1565 10 with with IN cord-010119-t1x9gknd 1565 11 5 5 CD cord-010119-t1x9gknd 1565 12 % % NN cord-010119-t1x9gknd 1565 13 DMSO DMSO NNP cord-010119-t1x9gknd 1565 14 and and CC cord-010119-t1x9gknd 1565 15 stored store VBN cord-010119-t1x9gknd 1565 16 at at IN cord-010119-t1x9gknd 1565 17 2808C. 2808c. CD cord-010119-t1x9gknd 1565 18 After after IN cord-010119-t1x9gknd 1565 19 thawing thaw VBG cord-010119-t1x9gknd 1565 20 , , , cord-010119-t1x9gknd 1565 21 the the DT cord-010119-t1x9gknd 1565 22 unit unit NN cord-010119-t1x9gknd 1565 23 was be VBD cord-010119-t1x9gknd 1565 24 reconstituted reconstitute VBN cord-010119-t1x9gknd 1565 25 in in IN cord-010119-t1x9gknd 1565 26 thawed thaw VBN cord-010119-t1x9gknd 1565 27 FFP FFP NNP cord-010119-t1x9gknd 1565 28 spiked spike VBN cord-010119-t1x9gknd 1565 29 with with IN cord-010119-t1x9gknd 1565 30 either either DT cord-010119-t1x9gknd 1565 31 500 500 CD cord-010119-t1x9gknd 1565 32 lM lm NN cord-010119-t1x9gknd 1565 33 puromycin puromycin NNS cord-010119-t1x9gknd 1565 34 ( ( -LRB- cord-010119-t1x9gknd 1565 35 Pm pm NN cord-010119-t1x9gknd 1565 36 ) ) -RRB- cord-010119-t1x9gknd 1565 37 or or CC cord-010119-t1x9gknd 1565 38 250 250 CD cord-010119-t1x9gknd 1565 39 nM nm NN cord-010119-t1x9gknd 1565 40 biotinlabeled biotinlabele VBN cord-010119-t1x9gknd 1565 41 Pm Pm NNP cord-010119-t1x9gknd 1565 42 . . . cord-010119-t1x9gknd 1566 1 PLTs plt NNS cord-010119-t1x9gknd 1566 2 were be VBD cord-010119-t1x9gknd 1566 3 stored store VBN cord-010119-t1x9gknd 1566 4 at at IN cord-010119-t1x9gknd 1566 5 room room NN cord-010119-t1x9gknd 1566 6 - - HYPH cord-010119-t1x9gknd 1566 7 temperature temperature NN cord-010119-t1x9gknd 1566 8 with with IN cord-010119-t1x9gknd 1566 9 agitation agitation NN cord-010119-t1x9gknd 1566 10 . . . cord-010119-t1x9gknd 1567 1 Samples sample NNS cord-010119-t1x9gknd 1567 2 were be VBD cord-010119-t1x9gknd 1567 3 drawn draw VBN cord-010119-t1x9gknd 1567 4 immediately immediately RB cord-010119-t1x9gknd 1567 5 after after IN cord-010119-t1x9gknd 1567 6 reconstitution reconstitution NN cord-010119-t1x9gknd 1567 7 as as RB cord-010119-t1x9gknd 1567 8 well well RB cord-010119-t1x9gknd 1567 9 as as IN cord-010119-t1x9gknd 1567 10 after after IN cord-010119-t1x9gknd 1567 11 2 2 CD cord-010119-t1x9gknd 1567 12 , , , cord-010119-t1x9gknd 1567 13 4 4 CD cord-010119-t1x9gknd 1567 14 and and CC cord-010119-t1x9gknd 1567 15 24 24 CD cord-010119-t1x9gknd 1567 16 hours hour NNS cord-010119-t1x9gknd 1567 17 to to TO cord-010119-t1x9gknd 1567 18 assess assess VB cord-010119-t1x9gknd 1567 19 Pm Pm NNP cord-010119-t1x9gknd 1567 20 incorporation incorporation NN cord-010119-t1x9gknd 1567 21 as as IN cord-010119-t1x9gknd 1567 22 a a DT cord-010119-t1x9gknd 1567 23 measure measure NN cord-010119-t1x9gknd 1567 24 of of IN cord-010119-t1x9gknd 1567 25 protein protein NN cord-010119-t1x9gknd 1567 26 synthesis synthesis NN cord-010119-t1x9gknd 1567 27 , , , cord-010119-t1x9gknd 1567 28 and and CC cord-010119-t1x9gknd 1567 29 for for IN cord-010119-t1x9gknd 1567 30 in in FW cord-010119-t1x9gknd 1567 31 vitro vitro FW cord-010119-t1x9gknd 1567 32 assays assay NNS cord-010119-t1x9gknd 1567 33 to to TO cord-010119-t1x9gknd 1567 34 determine determine VB cord-010119-t1x9gknd 1567 35 platelet platelet NN cord-010119-t1x9gknd 1567 36 activation activation NN cord-010119-t1x9gknd 1567 37 by by IN cord-010119-t1x9gknd 1567 38 CD62P CD62P NNP cord-010119-t1x9gknd 1567 39 binding bind VBG cord-010119-t1x9gknd 1567 40 , , , cord-010119-t1x9gknd 1567 41 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 1567 42 exposure exposure NN cord-010119-t1x9gknd 1567 43 by by IN cord-010119-t1x9gknd 1567 44 annexin annexin NN cord-010119-t1x9gknd 1567 45 - - HYPH cord-010119-t1x9gknd 1567 46 V v NN cord-010119-t1x9gknd 1567 47 binding binding NN cord-010119-t1x9gknd 1567 48 and and CC cord-010119-t1x9gknd 1567 49 microvesicle microvesicle NNP cord-010119-t1x9gknd 1567 50 count count NN cord-010119-t1x9gknd 1567 51 in in IN cord-010119-t1x9gknd 1567 52 the the DT cord-010119-t1x9gknd 1567 53 supernatant supernatant NN cord-010119-t1x9gknd 1567 54 . . . cord-010119-t1x9gknd 1568 1 PLT PLT NNP cord-010119-t1x9gknd 1568 2 microvesicles microvesicles NNP cord-010119-t1x9gknd 1568 3 ( ( -LRB- cord-010119-t1x9gknd 1568 4 PMV PMV NNP cord-010119-t1x9gknd 1568 5 ) ) -RRB- cord-010119-t1x9gknd 1568 6 were be VBD cord-010119-t1x9gknd 1568 7 prepared prepare VBN cord-010119-t1x9gknd 1568 8 from from IN cord-010119-t1x9gknd 1568 9 the the DT cord-010119-t1x9gknd 1568 10 supernatant supernatant NN cord-010119-t1x9gknd 1568 11 by by IN cord-010119-t1x9gknd 1568 12 ultracentrifugation ultracentrifugation NN cord-010119-t1x9gknd 1568 13 . . . cord-010119-t1x9gknd 1569 1 PLTs PLTs NNP cord-010119-t1x9gknd 1569 2 and and CC cord-010119-t1x9gknd 1569 3 PMV PMV NNP cord-010119-t1x9gknd 1569 4 were be VBD cord-010119-t1x9gknd 1569 5 lysed lyse VBN cord-010119-t1x9gknd 1569 6 in in IN cord-010119-t1x9gknd 1569 7 a a DT cord-010119-t1x9gknd 1569 8 Triton Triton NNP cord-010119-t1x9gknd 1569 9 X-100containing x-100containe VBG cord-010119-t1x9gknd 1569 10 buffer buffer NN cord-010119-t1x9gknd 1569 11 and and CC cord-010119-t1x9gknd 1569 12 qualitative qualitative JJ cord-010119-t1x9gknd 1569 13 proteomics proteomic NNS cord-010119-t1x9gknd 1569 14 was be VBD cord-010119-t1x9gknd 1569 15 performed perform VBN cord-010119-t1x9gknd 1569 16 on on IN cord-010119-t1x9gknd 1569 17 samples sample NNS cord-010119-t1x9gknd 1569 18 following follow VBG cord-010119-t1x9gknd 1569 19 affinity affinity NN cord-010119-t1x9gknd 1569 20 - - HYPH cord-010119-t1x9gknd 1569 21 purification purification NN cord-010119-t1x9gknd 1569 22 with with IN cord-010119-t1x9gknd 1569 23 streptavidin streptavidin NNP cord-010119-t1x9gknd 1569 24 beads bead NNS cord-010119-t1x9gknd 1569 25 . . . cord-010119-t1x9gknd 1570 1 Results result NNS cord-010119-t1x9gknd 1570 2 / / SYM cord-010119-t1x9gknd 1570 3 Findings finding NNS cord-010119-t1x9gknd 1570 4 : : : cord-010119-t1x9gknd 1571 1 In in IN cord-010119-t1x9gknd 1571 2 vitro vitro FW cord-010119-t1x9gknd 1571 3 parameters parameter NNS cord-010119-t1x9gknd 1571 4 of of IN cord-010119-t1x9gknd 1571 5 reconstituted reconstitute VBN cord-010119-t1x9gknd 1571 6 and and CC cord-010119-t1x9gknd 1571 7 subsequently subsequently RB cord-010119-t1x9gknd 1571 8 stored store VBN cord-010119-t1x9gknd 1571 9 platelets platelet NNS cord-010119-t1x9gknd 1571 10 were be VBD cord-010119-t1x9gknd 1571 11 in in IN cord-010119-t1x9gknd 1571 12 line line NN cord-010119-t1x9gknd 1571 13 with with IN cord-010119-t1x9gknd 1571 14 previously previously RB cord-010119-t1x9gknd 1571 15 published publish VBN cord-010119-t1x9gknd 1571 16 results result NNS cord-010119-t1x9gknd 1571 17 , , , cord-010119-t1x9gknd 1571 18 with with IN cord-010119-t1x9gknd 1571 19 high high JJ cord-010119-t1x9gknd 1571 20 surface surface NN cord-010119-t1x9gknd 1571 21 levels level NNS cord-010119-t1x9gknd 1571 22 of of IN cord-010119-t1x9gknd 1571 23 CD62P cd62p NN cord-010119-t1x9gknd 1571 24 and and CC cord-010119-t1x9gknd 1571 25 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 1571 26 . . . cord-010119-t1x9gknd 1572 1 PMVs pmv NNS cord-010119-t1x9gknd 1572 2 were be VBD cord-010119-t1x9gknd 1572 3 generated generate VBN cord-010119-t1x9gknd 1572 4 during during IN cord-010119-t1x9gknd 1572 5 cryopreservation cryopreservation NN cord-010119-t1x9gknd 1572 6 and and CC cord-010119-t1x9gknd 1572 7 the the DT cord-010119-t1x9gknd 1572 8 count count NN cord-010119-t1x9gknd 1572 9 increased increase VBD cord-010119-t1x9gknd 1572 10 by by IN cord-010119-t1x9gknd 1572 11 11-fold 11-fold CD cord-010119-t1x9gknd 1572 12 during during IN cord-010119-t1x9gknd 1572 13 24 24 CD cord-010119-t1x9gknd 1572 14 hour hour NN cord-010119-t1x9gknd 1572 15 storage storage NN cord-010119-t1x9gknd 1572 16 . . . cord-010119-t1x9gknd 1573 1 Immunoblot immunoblot NN cord-010119-t1x9gknd 1573 2 analyses analysis NNS cord-010119-t1x9gknd 1573 3 of of IN cord-010119-t1x9gknd 1573 4 the the DT cord-010119-t1x9gknd 1573 5 PLTs plt NNS cord-010119-t1x9gknd 1573 6 showed show VBD cord-010119-t1x9gknd 1573 7 a a DT cord-010119-t1x9gknd 1573 8 2-and 2-and CD cord-010119-t1x9gknd 1573 9 4-fold 4-fold CD cord-010119-t1x9gknd 1573 10 increase increase NN cord-010119-t1x9gknd 1573 11 in in IN cord-010119-t1x9gknd 1573 12 Pm pm NN cord-010119-t1x9gknd 1573 13 incorporation incorporation NN cord-010119-t1x9gknd 1573 14 after after IN cord-010119-t1x9gknd 1573 15 4 4 CD cord-010119-t1x9gknd 1573 16 and and CC cord-010119-t1x9gknd 1573 17 24 24 CD cord-010119-t1x9gknd 1573 18 hours hour NNS cord-010119-t1x9gknd 1573 19 of of IN cord-010119-t1x9gknd 1573 20 storage storage NN cord-010119-t1x9gknd 1573 21 , , , cord-010119-t1x9gknd 1573 22 respectively respectively RB cord-010119-t1x9gknd 1573 23 . . . cord-010119-t1x9gknd 1574 1 Massspectrometry Massspectrometry NNP cord-010119-t1x9gknd 1574 2 revealed reveal VBD cord-010119-t1x9gknd 1574 3 23 23 CD cord-010119-t1x9gknd 1574 4 unique unique JJ cord-010119-t1x9gknd 1574 5 proteins protein NNS cord-010119-t1x9gknd 1574 6 that that WDT cord-010119-t1x9gknd 1574 7 were be VBD cord-010119-t1x9gknd 1574 8 synthesized synthesize VBN cord-010119-t1x9gknd 1574 9 after after IN cord-010119-t1x9gknd 1574 10 4 4 CD cord-010119-t1x9gknd 1574 11 hours hour NNS cord-010119-t1x9gknd 1574 12 of of IN cord-010119-t1x9gknd 1574 13 storage storage NN cord-010119-t1x9gknd 1574 14 , , , cord-010119-t1x9gknd 1574 15 which which WDT cord-010119-t1x9gknd 1574 16 was be VBD cord-010119-t1x9gknd 1574 17 confirmed confirm VBN cord-010119-t1x9gknd 1574 18 for for IN cord-010119-t1x9gknd 1574 19 GTPase GTPase NNP cord-010119-t1x9gknd 1574 20 and and CC cord-010119-t1x9gknd 1574 21 GTPase GTPase NNP cord-010119-t1x9gknd 1574 22 - - HYPH cord-010119-t1x9gknd 1574 23 regulatory regulatory JJ cord-010119-t1x9gknd 1574 24 proteins protein NNS cord-010119-t1x9gknd 1574 25 Rac1 Rac1 NNP cord-010119-t1x9gknd 1574 26 , , , cord-010119-t1x9gknd 1574 27 Rap1 Rap1 NNP cord-010119-t1x9gknd 1574 28 and and CC cord-010119-t1x9gknd 1574 29 RhoGDI rhogdi NN cord-010119-t1x9gknd 1574 30 by by IN cord-010119-t1x9gknd 1574 31 immunoblot immunoblot NNP cord-010119-t1x9gknd 1574 32 analyses analysis NNS cord-010119-t1x9gknd 1574 33 . . . cord-010119-t1x9gknd 1575 1 Analyses analysis NNS cord-010119-t1x9gknd 1575 2 of of IN cord-010119-t1x9gknd 1575 3 the the DT cord-010119-t1x9gknd 1575 4 PMV PMV NNP cord-010119-t1x9gknd 1575 5 translatome translatome NNP cord-010119-t1x9gknd 1575 6 also also RB cord-010119-t1x9gknd 1575 7 revealed reveal VBD cord-010119-t1x9gknd 1575 8 the the DT cord-010119-t1x9gknd 1575 9 presence presence NN cord-010119-t1x9gknd 1575 10 of of IN cord-010119-t1x9gknd 1575 11 synthesized synthesize VBN cord-010119-t1x9gknd 1575 12 proteins protein NNS cord-010119-t1x9gknd 1575 13 ; ; : cord-010119-t1x9gknd 1575 14 however however RB cord-010119-t1x9gknd 1575 15 , , , cord-010119-t1x9gknd 1575 16 these these DT cord-010119-t1x9gknd 1575 17 did do VBD cord-010119-t1x9gknd 1575 18 not not RB cord-010119-t1x9gknd 1575 19 change change VB cord-010119-t1x9gknd 1575 20 throughout throughout IN cord-010119-t1x9gknd 1575 21 storage storage NN cord-010119-t1x9gknd 1575 22 . . . cord-010119-t1x9gknd 1576 1 This this DT cord-010119-t1x9gknd 1576 2 finding finding NN cord-010119-t1x9gknd 1576 3 suggests suggest VBZ cord-010119-t1x9gknd 1576 4 that that IN cord-010119-t1x9gknd 1576 5 a a DT cord-010119-t1x9gknd 1576 6 defined define VBN cord-010119-t1x9gknd 1576 7 panel panel NN cord-010119-t1x9gknd 1576 8 of of IN cord-010119-t1x9gknd 1576 9 proteins protein NNS cord-010119-t1x9gknd 1576 10 is be VBZ cord-010119-t1x9gknd 1576 11 packaged package VBN cord-010119-t1x9gknd 1576 12 into into IN cord-010119-t1x9gknd 1576 13 PMVs pmv NNS cord-010119-t1x9gknd 1576 14 upon upon IN cord-010119-t1x9gknd 1576 15 freezing freeze VBG cord-010119-t1x9gknd 1576 16 and and CC cord-010119-t1x9gknd 1576 17 thawing thawing NN cord-010119-t1x9gknd 1576 18 . . . cord-010119-t1x9gknd 1577 1 Additionally additionally RB cord-010119-t1x9gknd 1577 2 , , , cord-010119-t1x9gknd 1577 3 the the DT cord-010119-t1x9gknd 1577 4 PMV PMV NNP cord-010119-t1x9gknd 1577 5 translatome translatome NNP cord-010119-t1x9gknd 1577 6 profile profile NN cord-010119-t1x9gknd 1577 7 comprised comprise VBD cord-010119-t1x9gknd 1577 8 a a DT cord-010119-t1x9gknd 1577 9 smaller small JJR cord-010119-t1x9gknd 1577 10 subset subset JJ cord-010119-t1x9gknd 1577 11 of of IN cord-010119-t1x9gknd 1577 12 synthesized synthesize VBN cord-010119-t1x9gknd 1577 13 proteins protein NNS cord-010119-t1x9gknd 1577 14 compared compare VBN cord-010119-t1x9gknd 1577 15 to to IN cord-010119-t1x9gknd 1577 16 the the DT cord-010119-t1x9gknd 1577 17 cryo cryo NN cord-010119-t1x9gknd 1577 18 - - HYPH cord-010119-t1x9gknd 1577 19 PLT PLT NNP cord-010119-t1x9gknd 1577 20 translatome translatome NN cord-010119-t1x9gknd 1577 21 , , , cord-010119-t1x9gknd 1577 22 including include VBG cord-010119-t1x9gknd 1577 23 the the DT cord-010119-t1x9gknd 1577 24 proteins protein NNS cord-010119-t1x9gknd 1577 25 Rac1 Rac1 NNP cord-010119-t1x9gknd 1577 26 , , , cord-010119-t1x9gknd 1577 27 Rap1 Rap1 NNP cord-010119-t1x9gknd 1577 28 and and CC cord-010119-t1x9gknd 1577 29 RhoGDI rhogdi NN cord-010119-t1x9gknd 1577 30 . . . cord-010119-t1x9gknd 1578 1 Conclusion conclusion NN cord-010119-t1x9gknd 1578 2 : : : cord-010119-t1x9gknd 1579 1 This this DT cord-010119-t1x9gknd 1579 2 study study NN cord-010119-t1x9gknd 1579 3 has have VBZ cord-010119-t1x9gknd 1579 4 demonstrated demonstrate VBN cord-010119-t1x9gknd 1579 5 that that IN cord-010119-t1x9gknd 1579 6 cryo cryo NN cord-010119-t1x9gknd 1579 7 - - HYPH cord-010119-t1x9gknd 1579 8 PLTs plt NNS cord-010119-t1x9gknd 1579 9 can can MD cord-010119-t1x9gknd 1579 10 synthesize synthesize VB cord-010119-t1x9gknd 1579 11 proteins protein NNS cord-010119-t1x9gknd 1579 12 upon upon IN cord-010119-t1x9gknd 1579 13 reconstitution reconstitution NN cord-010119-t1x9gknd 1579 14 in in IN cord-010119-t1x9gknd 1579 15 FFP FFP NNP cord-010119-t1x9gknd 1579 16 and and CC cord-010119-t1x9gknd 1579 17 subsequent subsequent JJ cord-010119-t1x9gknd 1579 18 storage storage NN cord-010119-t1x9gknd 1579 19 . . . cord-010119-t1x9gknd 1580 1 Discovery discovery NN cord-010119-t1x9gknd 1580 2 of of IN cord-010119-t1x9gknd 1580 3 a a DT cord-010119-t1x9gknd 1580 4 subset subset NN cord-010119-t1x9gknd 1580 5 of of IN cord-010119-t1x9gknd 1580 6 these these DT cord-010119-t1x9gknd 1580 7 proteins protein NNS cord-010119-t1x9gknd 1580 8 in in IN cord-010119-t1x9gknd 1580 9 the the DT cord-010119-t1x9gknd 1580 10 PMV PMV NNP cord-010119-t1x9gknd 1580 11 suggests suggest VBZ cord-010119-t1x9gknd 1580 12 their -PRON- PRP$ cord-010119-t1x9gknd 1580 13 encapsulation encapsulation NN cord-010119-t1x9gknd 1580 14 , , , cord-010119-t1x9gknd 1580 15 possibly possibly RB cord-010119-t1x9gknd 1580 16 in in IN cord-010119-t1x9gknd 1580 17 a a DT cord-010119-t1x9gknd 1580 18 selective selective JJ cord-010119-t1x9gknd 1580 19 manner manner NN cord-010119-t1x9gknd 1580 20 . . . cord-010119-t1x9gknd 1581 1 This this DT cord-010119-t1x9gknd 1581 2 observation observation NN cord-010119-t1x9gknd 1581 3 provides provide VBZ cord-010119-t1x9gknd 1581 4 novel novel JJ cord-010119-t1x9gknd 1581 5 insights insight NNS cord-010119-t1x9gknd 1581 6 into into IN cord-010119-t1x9gknd 1581 7 the the DT cord-010119-t1x9gknd 1581 8 capacity capacity NN cord-010119-t1x9gknd 1581 9 for for IN cord-010119-t1x9gknd 1581 10 protein protein NN cord-010119-t1x9gknd 1581 11 synthesis synthesis NN cord-010119-t1x9gknd 1581 12 in in IN cord-010119-t1x9gknd 1581 13 cryo cryo NN cord-010119-t1x9gknd 1581 14 - - HYPH cord-010119-t1x9gknd 1581 15 PLTs plt NNS cord-010119-t1x9gknd 1581 16 and and CC cord-010119-t1x9gknd 1581 17 the the DT cord-010119-t1x9gknd 1581 18 potential potential JJ cord-010119-t1x9gknd 1581 19 regulation regulation NN cord-010119-t1x9gknd 1581 20 of of IN cord-010119-t1x9gknd 1581 21 protein protein NN cord-010119-t1x9gknd 1581 22 packaging packaging NN cord-010119-t1x9gknd 1581 23 into into IN cord-010119-t1x9gknd 1581 24 PMV PMV NNP cord-010119-t1x9gknd 1581 25 . . . cord-010119-t1x9gknd 1582 1 Background Background NNP cord-010119-t1x9gknd 1582 2 / / SYM cord-010119-t1x9gknd 1582 3 Case Case NNP cord-010119-t1x9gknd 1582 4 Studies Studies NNPS cord-010119-t1x9gknd 1582 5 : : : cord-010119-t1x9gknd 1583 1 In in IN cord-010119-t1x9gknd 1583 2 2015 2015 CD cord-010119-t1x9gknd 1583 3 , , , cord-010119-t1x9gknd 1583 4 the the DT cord-010119-t1x9gknd 1583 5 authors author NNS cord-010119-t1x9gknd 1583 6 ' ' POS cord-010119-t1x9gknd 1583 7 hospital hospital NN cord-010119-t1x9gknd 1583 8 - - HYPH cord-010119-t1x9gknd 1583 9 based base VBN cord-010119-t1x9gknd 1583 10 blood blood NN cord-010119-t1x9gknd 1583 11 bank bank NN cord-010119-t1x9gknd 1583 12 received receive VBD cord-010119-t1x9gknd 1583 13 variances variance NNS cord-010119-t1x9gknd 1583 14 from from IN cord-010119-t1x9gknd 1583 15 the the DT cord-010119-t1x9gknd 1583 16 FDA FDA NNP cord-010119-t1x9gknd 1583 17 and and CC cord-010119-t1x9gknd 1583 18 AABB AABB NNP cord-010119-t1x9gknd 1583 19 for for IN cord-010119-t1x9gknd 1583 20 the the DT cord-010119-t1x9gknd 1583 21 use use NN cord-010119-t1x9gknd 1583 22 of of IN cord-010119-t1x9gknd 1583 23 cold cold JJ cord-010119-t1x9gknd 1583 24 stored store VBN cord-010119-t1x9gknd 1583 25 platelets platelet NNS cord-010119-t1x9gknd 1583 26 ( ( -LRB- cord-010119-t1x9gknd 1583 27 CSPs csp NNS cord-010119-t1x9gknd 1583 28 ) ) -RRB- cord-010119-t1x9gknd 1583 29 with with IN cord-010119-t1x9gknd 1583 30 a a DT cord-010119-t1x9gknd 1583 31 shelf shelf NN cord-010119-t1x9gknd 1583 32 life life NN cord-010119-t1x9gknd 1583 33 of of IN cord-010119-t1x9gknd 1583 34 3 3 CD cord-010119-t1x9gknd 1583 35 days day NNS cord-010119-t1x9gknd 1583 36 . . . cord-010119-t1x9gknd 1584 1 These these DT cord-010119-t1x9gknd 1584 2 group group NN cord-010119-t1x9gknd 1584 3 A a DT cord-010119-t1x9gknd 1584 4 CSPs csp NNS cord-010119-t1x9gknd 1584 5 , , , cord-010119-t1x9gknd 1584 6 stored store VBN cord-010119-t1x9gknd 1584 7 in in IN cord-010119-t1x9gknd 1584 8 a a DT cord-010119-t1x9gknd 1584 9 refrigerator refrigerator NN cord-010119-t1x9gknd 1584 10 in in IN cord-010119-t1x9gknd 1584 11 the the DT cord-010119-t1x9gknd 1584 12 Emergency Emergency NNP cord-010119-t1x9gknd 1584 13 Department Department NNP cord-010119-t1x9gknd 1584 14 , , , cord-010119-t1x9gknd 1584 15 were be VBD cord-010119-t1x9gknd 1584 16 used use VBN cord-010119-t1x9gknd 1584 17 to to TO cord-010119-t1x9gknd 1584 18 support support VB cord-010119-t1x9gknd 1584 19 the the DT cord-010119-t1x9gknd 1584 20 trauma trauma NN cord-010119-t1x9gknd 1584 21 program program NN cord-010119-t1x9gknd 1584 22 for for IN cord-010119-t1x9gknd 1584 23 use use NN cord-010119-t1x9gknd 1584 24 in in IN cord-010119-t1x9gknd 1584 25 massively massively RB cord-010119-t1x9gknd 1584 26 bleeding bleed VBG cord-010119-t1x9gknd 1584 27 patients patient NNS cord-010119-t1x9gknd 1584 28 . . . cord-010119-t1x9gknd 1585 1 The the DT cord-010119-t1x9gknd 1585 2 placement placement NN cord-010119-t1x9gknd 1585 3 of of IN cord-010119-t1x9gknd 1585 4 the the DT cord-010119-t1x9gknd 1585 5 CSPs csp NNS cord-010119-t1x9gknd 1585 6 on on IN cord-010119-t1x9gknd 1585 7 the the DT cord-010119-t1x9gknd 1585 8 air air NN cord-010119-t1x9gknd 1585 9 ambulances ambulance NNS cord-010119-t1x9gknd 1585 10 , , , cord-010119-t1x9gknd 1585 11 stored store VBN cord-010119-t1x9gknd 1585 12 in in IN cord-010119-t1x9gknd 1585 13 coolers cooler NNS cord-010119-t1x9gknd 1585 14 , , , cord-010119-t1x9gknd 1585 15 was be VBD cord-010119-t1x9gknd 1585 16 the the DT cord-010119-t1x9gknd 1585 17 next next JJ cord-010119-t1x9gknd 1585 18 logical logical JJ cord-010119-t1x9gknd 1585 19 step step NN cord-010119-t1x9gknd 1585 20 in in IN cord-010119-t1x9gknd 1585 21 providing provide VBG cord-010119-t1x9gknd 1585 22 platelet platelet NN cord-010119-t1x9gknd 1585 23 therapy therapy NN cord-010119-t1x9gknd 1585 24 sooner soon RBR cord-010119-t1x9gknd 1585 25 to to IN cord-010119-t1x9gknd 1585 26 these these DT cord-010119-t1x9gknd 1585 27 patients patient NNS cord-010119-t1x9gknd 1585 28 . . . cord-010119-t1x9gknd 1586 1 Study Study NNP cord-010119-t1x9gknd 1586 2 Design Design NNP cord-010119-t1x9gknd 1586 3 / / SYM cord-010119-t1x9gknd 1586 4 Methods method NNS cord-010119-t1x9gknd 1586 5 : : : cord-010119-t1x9gknd 1587 1 Eight eight CD cord-010119-t1x9gknd 1587 2 double double JJ cord-010119-t1x9gknd 1587 3 unit unit NN cord-010119-t1x9gknd 1587 4 CSPs csp NNS cord-010119-t1x9gknd 1587 5 were be VBD cord-010119-t1x9gknd 1587 6 collected collect VBN cord-010119-t1x9gknd 1587 7 using use VBG cord-010119-t1x9gknd 1587 8 the the DT cord-010119-t1x9gknd 1587 9 Trima Trima NNP cord-010119-t1x9gknd 1587 10 AccelV accelv IN cord-010119-t1x9gknd 1587 11 R R NNP cord-010119-t1x9gknd 1587 12 . . . cord-010119-t1x9gknd 1588 1 Two two CD cord-010119-t1x9gknd 1588 2 double double JJ cord-010119-t1x9gknd 1588 3 CSPs csp NNS cord-010119-t1x9gknd 1588 4 were be VBD cord-010119-t1x9gknd 1588 5 pathogen pathogen NN cord-010119-t1x9gknd 1588 6 reduced reduce VBN cord-010119-t1x9gknd 1588 7 using use VBG cord-010119-t1x9gknd 1588 8 the the DT cord-010119-t1x9gknd 1588 9 Inter Inter NNP cord-010119-t1x9gknd 1588 10 - - HYPH cord-010119-t1x9gknd 1588 11 ceptV ceptV NNP cord-010119-t1x9gknd 1588 12 R r NN cord-010119-t1x9gknd 1588 13 pathogen pathogen NN cord-010119-t1x9gknd 1588 14 reduction reduction NN cord-010119-t1x9gknd 1588 15 system system NN cord-010119-t1x9gknd 1588 16 . . . cord-010119-t1x9gknd 1589 1 Half half NN cord-010119-t1x9gknd 1589 2 of of IN cord-010119-t1x9gknd 1589 3 the the DT cord-010119-t1x9gknd 1589 4 CSP CSP NNP cord-010119-t1x9gknd 1589 5 pairs pair NNS cord-010119-t1x9gknd 1589 6 were be VBD cord-010119-t1x9gknd 1589 7 subjected subject VBN cord-010119-t1x9gknd 1589 8 to to IN cord-010119-t1x9gknd 1589 9 flat flat JJ cord-010119-t1x9gknd 1589 10 storage storage NN cord-010119-t1x9gknd 1589 11 in in IN cord-010119-t1x9gknd 1589 12 a a DT cord-010119-t1x9gknd 1589 13 refrigerator refrigerator NN cord-010119-t1x9gknd 1589 14 ; ; : cord-010119-t1x9gknd 1589 15 the the DT cord-010119-t1x9gknd 1589 16 other other JJ cord-010119-t1x9gknd 1589 17 half half NN cord-010119-t1x9gknd 1589 18 were be VBD cord-010119-t1x9gknd 1589 19 loaded load VBN cord-010119-t1x9gknd 1589 20 into into IN cord-010119-t1x9gknd 1589 21 a a DT cord-010119-t1x9gknd 1589 22 CredoV credov JJ cord-010119-t1x9gknd 1589 23 R R NNP cord-010119-t1x9gknd 1589 24 4 4 CD cord-010119-t1x9gknd 1589 25 - - SYM cord-010119-t1x9gknd 1589 26 496 496 CD cord-010119-t1x9gknd 1589 27 cooler cooler NN cord-010119-t1x9gknd 1589 28 with with IN cord-010119-t1x9gknd 1589 29 2 2 CD cord-010119-t1x9gknd 1589 30 units unit NNS cord-010119-t1x9gknd 1589 31 of of IN cord-010119-t1x9gknd 1589 32 FFP FFP NNP cord-010119-t1x9gknd 1589 33 , , , cord-010119-t1x9gknd 1589 34 2 2 CD cord-010119-t1x9gknd 1589 35 units unit NNS cord-010119-t1x9gknd 1589 36 of of IN cord-010119-t1x9gknd 1589 37 RBCs rbc NNS cord-010119-t1x9gknd 1589 38 , , , cord-010119-t1x9gknd 1589 39 and and CC cord-010119-t1x9gknd 1589 40 1 1 CD cord-010119-t1x9gknd 1589 41 unit unit NN cord-010119-t1x9gknd 1589 42 of of IN cord-010119-t1x9gknd 1589 43 whole whole JJ cord-010119-t1x9gknd 1589 44 blood blood NN cord-010119-t1x9gknd 1589 45 . . . cord-010119-t1x9gknd 1590 1 Three three CD cord-010119-t1x9gknd 1590 2 to to IN cord-010119-t1x9gknd 1590 3 5mL 5ml CD cord-010119-t1x9gknd 1590 4 of of IN cord-010119-t1x9gknd 1590 5 platelets platelet NNS cord-010119-t1x9gknd 1590 6 were be VBD cord-010119-t1x9gknd 1590 7 collected collect VBN cord-010119-t1x9gknd 1590 8 via via IN cord-010119-t1x9gknd 1590 9 syringe syringe NN cord-010119-t1x9gknd 1590 10 from from IN cord-010119-t1x9gknd 1590 11 each each DT cord-010119-t1x9gknd 1590 12 unit unit NN cord-010119-t1x9gknd 1590 13 at at IN cord-010119-t1x9gknd 1590 14 0 0 CD cord-010119-t1x9gknd 1590 15 min min NN cord-010119-t1x9gknd 1590 16 ( ( -LRB- cord-010119-t1x9gknd 1590 17 before before IN cord-010119-t1x9gknd 1590 18 storage storage NN cord-010119-t1x9gknd 1590 19 in in IN cord-010119-t1x9gknd 1590 20 cooler cooler NN cord-010119-t1x9gknd 1590 21 or or CC cord-010119-t1x9gknd 1590 22 refrigerator refrigerator NN cord-010119-t1x9gknd 1590 23 ) ) -RRB- cord-010119-t1x9gknd 1590 24 and and CC cord-010119-t1x9gknd 1590 25 after after IN cord-010119-t1x9gknd 1590 26 0.5 0.5 CD cord-010119-t1x9gknd 1590 27 , , , cord-010119-t1x9gknd 1590 28 1 1 CD cord-010119-t1x9gknd 1590 29 , , , cord-010119-t1x9gknd 1590 30 3 3 CD cord-010119-t1x9gknd 1590 31 , , , cord-010119-t1x9gknd 1590 32 5 5 CD cord-010119-t1x9gknd 1590 33 , , , cord-010119-t1x9gknd 1590 34 and and CC cord-010119-t1x9gknd 1590 35 6 6 CD cord-010119-t1x9gknd 1590 36 hours hour NNS cord-010119-t1x9gknd 1590 37 of of IN cord-010119-t1x9gknd 1590 38 storage storage NN cord-010119-t1x9gknd 1590 39 for for IN cord-010119-t1x9gknd 1590 40 functional functional JJ cord-010119-t1x9gknd 1590 41 validation validation NN cord-010119-t1x9gknd 1590 42 of of IN cord-010119-t1x9gknd 1590 43 platelets platelet NNS cord-010119-t1x9gknd 1590 44 . . . cord-010119-t1x9gknd 1591 1 The the DT cord-010119-t1x9gknd 1591 2 platelet platelet NN cord-010119-t1x9gknd 1591 3 count count NN cord-010119-t1x9gknd 1591 4 , , , cord-010119-t1x9gknd 1591 5 agonists agonist NNS cord-010119-t1x9gknd 1591 6 ( ( -LRB- cord-010119-t1x9gknd 1591 7 thrombin thrombin JJ cord-010119-t1x9gknd 1591 8 receptor receptor NN cord-010119-t1x9gknd 1591 9 agonist agonist NN cord-010119-t1x9gknd 1591 10 peptide peptide NN cord-010119-t1x9gknd 1591 11 ( ( -LRB- cord-010119-t1x9gknd 1591 12 TRAP TRAP NNP cord-010119-t1x9gknd 1591 13 ) ) -RRB- cord-010119-t1x9gknd 1591 14 , , , cord-010119-t1x9gknd 1591 15 adenosine adenosine NN cord-010119-t1x9gknd 1591 16 diphosphate diphosphate NN cord-010119-t1x9gknd 1591 17 ( ( -LRB- cord-010119-t1x9gknd 1591 18 ADP ADP NNP cord-010119-t1x9gknd 1591 19 ) ) -RRB- cord-010119-t1x9gknd 1591 20 and and CC cord-010119-t1x9gknd 1591 21 collagen collagen NN cord-010119-t1x9gknd 1591 22 stimulated stimulate VBD cord-010119-t1x9gknd 1591 23 platelets platelet NNS cord-010119-t1x9gknd 1591 24 aggregation aggregation NN cord-010119-t1x9gknd 1591 25 ) ) -RRB- cord-010119-t1x9gknd 1591 26 , , , cord-010119-t1x9gknd 1591 27 non non JJ cord-010119-t1x9gknd 1591 28 - - JJ cord-010119-t1x9gknd 1591 29 activated activated JJ cord-010119-t1x9gknd 1591 30 and and CC cord-010119-t1x9gknd 1591 31 agonists agonist NNS cord-010119-t1x9gknd 1591 32 activated activate VBD cord-010119-t1x9gknd 1591 33 platelet platelet NN cord-010119-t1x9gknd 1591 34 surface surface NN cord-010119-t1x9gknd 1591 35 expression expression NN cord-010119-t1x9gknd 1591 36 of of IN cord-010119-t1x9gknd 1591 37 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 1591 38 ( ( -LRB- cord-010119-t1x9gknd 1591 39 PS PS NNP cord-010119-t1x9gknd 1591 40 , , , cord-010119-t1x9gknd 1591 41 annexin annexin NN cord-010119-t1x9gknd 1591 42 - - HYPH cord-010119-t1x9gknd 1591 43 V v NN cord-010119-t1x9gknd 1591 44 binding binding NN cord-010119-t1x9gknd 1591 45 ) ) -RRB- cord-010119-t1x9gknd 1591 46 , , , cord-010119-t1x9gknd 1591 47 P p NN cord-010119-t1x9gknd 1591 48 - - HYPH cord-010119-t1x9gknd 1591 49 selectin selectin NNP cord-010119-t1x9gknd 1591 50 , , , cord-010119-t1x9gknd 1591 51 fibrinogen fibrinogen NN cord-010119-t1x9gknd 1591 52 receptor receptor NN cord-010119-t1x9gknd 1591 53 ( ( -LRB- cord-010119-t1x9gknd 1591 54 PAC-1 PAC-1 NNP cord-010119-t1x9gknd 1591 55 binding bind VBG cord-010119-t1x9gknd 1591 56 ) ) -RRB- cord-010119-t1x9gknd 1591 57 were be VBD cord-010119-t1x9gknd 1591 58 measured measure VBN cord-010119-t1x9gknd 1591 59 by by IN cord-010119-t1x9gknd 1591 60 Coulter Coulter NNP cord-010119-t1x9gknd 1591 61 counter counter NN cord-010119-t1x9gknd 1591 62 , , , cord-010119-t1x9gknd 1591 63 2 2 CD cord-010119-t1x9gknd 1591 64 channel channel NN cord-010119-t1x9gknd 1591 65 aggregometer aggregometer NN cord-010119-t1x9gknd 1591 66 , , , cord-010119-t1x9gknd 1591 67 and and CC cord-010119-t1x9gknd 1591 68 digital digital JJ cord-010119-t1x9gknd 1591 69 flow flow NN cord-010119-t1x9gknd 1591 70 cytometer cytometer NN cord-010119-t1x9gknd 1591 71 . . . cord-010119-t1x9gknd 1592 1 Paired paired JJ cord-010119-t1x9gknd 1592 2 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 1592 3 rank rank NN cord-010119-t1x9gknd 1592 4 sum sum NN cord-010119-t1x9gknd 1592 5 tests test NNS cord-010119-t1x9gknd 1592 6 were be VBD cord-010119-t1x9gknd 1592 7 used use VBN cord-010119-t1x9gknd 1592 8 to to TO cord-010119-t1x9gknd 1592 9 analyze analyze VB cord-010119-t1x9gknd 1592 10 differences difference NNS cord-010119-t1x9gknd 1592 11 in in IN cord-010119-t1x9gknd 1592 12 degradation degradation NN cord-010119-t1x9gknd 1592 13 rates rate NNS cord-010119-t1x9gknd 1592 14 with with IN cord-010119-t1x9gknd 1592 15 p<0.05 p<0.05 JJ cord-010119-t1x9gknd 1592 16 deemed deem VBN cord-010119-t1x9gknd 1592 17 significant significant JJ cord-010119-t1x9gknd 1592 18 . . . cord-010119-t1x9gknd 1593 1 Conclusion conclusion NN cord-010119-t1x9gknd 1593 2 : : : cord-010119-t1x9gknd 1594 1 Platelets platelet NNS cord-010119-t1x9gknd 1594 2 , , , cord-010119-t1x9gknd 1594 3 including include VBG cord-010119-t1x9gknd 1594 4 pathogen pathogen NN cord-010119-t1x9gknd 1594 5 reduced reduce VBN cord-010119-t1x9gknd 1594 6 , , , cord-010119-t1x9gknd 1594 7 stored store VBN cord-010119-t1x9gknd 1594 8 in in IN cord-010119-t1x9gknd 1594 9 an an DT cord-010119-t1x9gknd 1594 10 oxygendeprived oxygendeprived JJ cord-010119-t1x9gknd 1594 11 environment environment NN cord-010119-t1x9gknd 1594 12 , , , cord-010119-t1x9gknd 1594 13 ( ( -LRB- cord-010119-t1x9gknd 1594 14 cooler cooler RBR cord-010119-t1x9gknd 1594 15 ) ) -RRB- cord-010119-t1x9gknd 1594 16 , , , cord-010119-t1x9gknd 1594 17 do do VBP cord-010119-t1x9gknd 1594 18 not not RB cord-010119-t1x9gknd 1594 19 lose lose VB cord-010119-t1x9gknd 1594 20 functional functional JJ cord-010119-t1x9gknd 1594 21 capabilities capability NNS cord-010119-t1x9gknd 1594 22 when when WRB cord-010119-t1x9gknd 1594 23 compared compare VBN cord-010119-t1x9gknd 1594 24 to to IN cord-010119-t1x9gknd 1594 25 those those DT cord-010119-t1x9gknd 1594 26 platelets platelet NNS cord-010119-t1x9gknd 1594 27 stored store VBN cord-010119-t1x9gknd 1594 28 in in IN cord-010119-t1x9gknd 1594 29 a a DT cord-010119-t1x9gknd 1594 30 refrigerator refrigerator NN cord-010119-t1x9gknd 1594 31 with with IN cord-010119-t1x9gknd 1594 32 adequate adequate JJ cord-010119-t1x9gknd 1594 33 oxygen oxygen NN cord-010119-t1x9gknd 1594 34 for for IN cord-010119-t1x9gknd 1594 35 6 6 CD cord-010119-t1x9gknd 1594 36 hours hour NNS cord-010119-t1x9gknd 1594 37 . . . cord-010119-t1x9gknd 1595 1 Therefore therefore RB cord-010119-t1x9gknd 1595 2 , , , cord-010119-t1x9gknd 1595 3 cold cold JJ cord-010119-t1x9gknd 1595 4 stored stored JJ cord-010119-t1x9gknd 1595 5 platelets platelet NNS cord-010119-t1x9gknd 1595 6 transported transport VBN cord-010119-t1x9gknd 1595 7 in in IN cord-010119-t1x9gknd 1595 8 a a DT cord-010119-t1x9gknd 1595 9 cooler cooler NN cord-010119-t1x9gknd 1595 10 are be VBP cord-010119-t1x9gknd 1595 11 a a DT cord-010119-t1x9gknd 1595 12 viable viable JJ cord-010119-t1x9gknd 1595 13 option option NN cord-010119-t1x9gknd 1595 14 for for IN cord-010119-t1x9gknd 1595 15 providing provide VBG cord-010119-t1x9gknd 1595 16 timelier timely JJR cord-010119-t1x9gknd 1595 17 platelet platelet NN cord-010119-t1x9gknd 1595 18 intervention intervention NN cord-010119-t1x9gknd 1595 19 for for IN cord-010119-t1x9gknd 1595 20 severely severely RB cord-010119-t1x9gknd 1595 21 injured injure VBN cord-010119-t1x9gknd 1595 22 patients patient NNS cord-010119-t1x9gknd 1595 23 prior prior RB cord-010119-t1x9gknd 1595 24 to to IN cord-010119-t1x9gknd 1595 25 hospital hospital NN cord-010119-t1x9gknd 1595 26 arrival arrival NN cord-010119-t1x9gknd 1595 27 . . . cord-010119-t1x9gknd 1596 1 C49-A03H C49-A03H NNP cord-010119-t1x9gknd 1596 2 Molecular Molecular NNP cord-010119-t1x9gknd 1596 3 Sieving Sieving NNP cord-010119-t1x9gknd 1596 4 : : : cord-010119-t1x9gknd 1597 1 Beyond beyond IN cord-010119-t1x9gknd 1597 2 Genotyping Genotyping NNP cord-010119-t1x9gknd 1597 3 Ghazala Ghazala NNP cord-010119-t1x9gknd 1597 4 Hashmi Hashmi NNP cord-010119-t1x9gknd 1597 5 1 1 CD cord-010119-t1x9gknd 1597 6 , , , cord-010119-t1x9gknd 1597 7 Reinhard Reinhard NNP cord-010119-t1x9gknd 1597 8 Klemm Klemm NNP cord-010119-t1x9gknd 1597 9 2 2 CD cord-010119-t1x9gknd 1597 10 and and CC cord-010119-t1x9gknd 1597 11 Michael Michael NNP cord-010119-t1x9gknd 1597 12 Seul Seul NNP cord-010119-t1x9gknd 1597 13 * * NFP cord-010119-t1x9gknd 1597 14 1,2 1,2 CD cord-010119-t1x9gknd 1597 15 . . . cord-010119-t1x9gknd 1597 16 1 1 CD cord-010119-t1x9gknd 1597 17 BioMolecular BioMolecular NNP cord-010119-t1x9gknd 1597 18 Analytics Analytics NNP cord-010119-t1x9gknd 1597 19 , , , cord-010119-t1x9gknd 1597 20 2 2 CD cord-010119-t1x9gknd 1597 21 ImmunoInformatica ImmunoInformatica NNP cord-010119-t1x9gknd 1597 22 Background Background NNP cord-010119-t1x9gknd 1597 23 / / SYM cord-010119-t1x9gknd 1597 24 Case Case NNP cord-010119-t1x9gknd 1597 25 Studies Studies NNPS cord-010119-t1x9gknd 1597 26 : : : cord-010119-t1x9gknd 1598 1 More More JJR cord-010119-t1x9gknd 1598 2 than than IN cord-010119-t1x9gknd 1598 3 a a DT cord-010119-t1x9gknd 1598 4 decade decade NN cord-010119-t1x9gknd 1598 5 after after IN cord-010119-t1x9gknd 1598 6 its -PRON- PRP$ cord-010119-t1x9gknd 1598 7 commercial commercial JJ cord-010119-t1x9gknd 1598 8 introduction introduction NN cord-010119-t1x9gknd 1598 9 ( ( -LRB- cord-010119-t1x9gknd 1598 10 Hashmi2005 Hashmi2005 NNP cord-010119-t1x9gknd 1598 11 http://bit.ly/2oHLehE http://bit.ly/2oHLehE NNP cord-010119-t1x9gknd 1598 12 ) ) -RRB- cord-010119-t1x9gknd 1598 13 , , , cord-010119-t1x9gknd 1598 14 blood blood NN cord-010119-t1x9gknd 1598 15 group group NN cord-010119-t1x9gknd 1598 16 genotyping genotyping NN cord-010119-t1x9gknd 1598 17 , , , cord-010119-t1x9gknd 1598 18 though though IN cord-010119-t1x9gknd 1598 19 available available JJ cord-010119-t1x9gknd 1598 20 in in IN cord-010119-t1x9gknd 1598 21 several several JJ cord-010119-t1x9gknd 1598 22 formats format NNS cord-010119-t1x9gknd 1598 23 , , , cord-010119-t1x9gknd 1598 24 has have VBZ cord-010119-t1x9gknd 1598 25 remained remain VBN cord-010119-t1x9gknd 1598 26 a a DT cord-010119-t1x9gknd 1598 27 tool tool NN cord-010119-t1x9gknd 1598 28 for for IN cord-010119-t1x9gknd 1598 29 special special JJ cord-010119-t1x9gknd 1598 30 tasks task NNS cord-010119-t1x9gknd 1598 31 , , , cord-010119-t1x9gknd 1598 32 e.g. e.g. IN cord-010119-t1x9gknd 1598 33 the the DT cord-010119-t1x9gknd 1598 34 profiling profiling NN cord-010119-t1x9gknd 1598 35 of of IN cord-010119-t1x9gknd 1598 36 difficult difficult JJ cord-010119-t1x9gknd 1598 37 patient patient NN cord-010119-t1x9gknd 1598 38 samples sample NNS cord-010119-t1x9gknd 1598 39 or or CC cord-010119-t1x9gknd 1598 40 the the DT cord-010119-t1x9gknd 1598 41 identification identification NN cord-010119-t1x9gknd 1598 42 of of IN cord-010119-t1x9gknd 1598 43 rare rare JJ cord-010119-t1x9gknd 1598 44 antigen antigen NN cord-010119-t1x9gknd 1598 45 combinations combination NNS cord-010119-t1x9gknd 1598 46 , , , cord-010119-t1x9gknd 1598 47 while while IN cord-010119-t1x9gknd 1598 48 serology serology NN cord-010119-t1x9gknd 1598 49 has have VBZ cord-010119-t1x9gknd 1598 50 remained remain VBN cord-010119-t1x9gknd 1598 51 the the DT cord-010119-t1x9gknd 1598 52 tool tool NN cord-010119-t1x9gknd 1598 53 of of IN cord-010119-t1x9gknd 1598 54 choice choice NN cord-010119-t1x9gknd 1598 55 for for IN cord-010119-t1x9gknd 1598 56 routine routine JJ cord-010119-t1x9gknd 1598 57 antigen antigen NN cord-010119-t1x9gknd 1598 58 typing typing NN cord-010119-t1x9gknd 1598 59 . . . cord-010119-t1x9gknd 1599 1 Here here RB cord-010119-t1x9gknd 1599 2 , , , cord-010119-t1x9gknd 1599 3 we -PRON- PRP cord-010119-t1x9gknd 1599 4 introduce introduce VBP cord-010119-t1x9gknd 1599 5 Molecular Molecular NNP cord-010119-t1x9gknd 1599 6 Sieving Sieving NNP cord-010119-t1x9gknd 1599 7 as as IN cord-010119-t1x9gknd 1599 8 an an DT cord-010119-t1x9gknd 1599 9 alternative alternative NN cord-010119-t1x9gknd 1599 10 to to IN cord-010119-t1x9gknd 1599 11 the the DT cord-010119-t1x9gknd 1599 12 current current JJ cord-010119-t1x9gknd 1599 13 approach approach NN cord-010119-t1x9gknd 1599 14 of of IN cord-010119-t1x9gknd 1599 15 managing manage VBG cord-010119-t1x9gknd 1599 16 special special JJ cord-010119-t1x9gknd 1599 17 donor donor NN cord-010119-t1x9gknd 1599 18 unit unit NN cord-010119-t1x9gknd 1599 19 inventories inventory NNS cord-010119-t1x9gknd 1599 20 . . . cord-010119-t1x9gknd 1600 1 This this DT cord-010119-t1x9gknd 1600 2 novel novel NN cord-010119-t1x9gknd 1600 3 process process NN cord-010119-t1x9gknd 1600 4 for for IN cord-010119-t1x9gknd 1600 5 DNA dna NN cord-010119-t1x9gknd 1600 6 analysis analysis NN cord-010119-t1x9gknd 1600 7 combines combine VBZ cord-010119-t1x9gknd 1600 8 the the DT cord-010119-t1x9gknd 1600 9 " " `` cord-010119-t1x9gknd 1600 10 multiplexing multiplexing NN cord-010119-t1x9gknd 1600 11 " " '' cord-010119-t1x9gknd 1600 12 of of IN cord-010119-t1x9gknd 1600 13 markers marker NNS cord-010119-t1x9gknd 1600 14 offered offer VBN cord-010119-t1x9gknd 1600 15 by by IN cord-010119-t1x9gknd 1600 16 existing exist VBG cord-010119-t1x9gknd 1600 17 genotyping genotyping NN cord-010119-t1x9gknd 1600 18 methods method NNS cord-010119-t1x9gknd 1600 19 with with IN cord-010119-t1x9gknd 1600 20 the the DT cord-010119-t1x9gknd 1600 21 pooling pooling NN cord-010119-t1x9gknd 1600 22 of of IN cord-010119-t1x9gknd 1600 23 multiple multiple JJ cord-010119-t1x9gknd 1600 24 samples sample NNS cord-010119-t1x9gknd 1600 25 in in IN cord-010119-t1x9gknd 1600 26 manner manner NN cord-010119-t1x9gknd 1600 27 permitting permit VBG cord-010119-t1x9gknd 1600 28 the the DT cord-010119-t1x9gknd 1600 29 step step NN cord-010119-t1x9gknd 1600 30 -wise -wise NN cord-010119-t1x9gknd 1600 31 refinement refinement NN cord-010119-t1x9gknd 1600 32 of of IN cord-010119-t1x9gknd 1600 33 candidate candidate NN cord-010119-t1x9gknd 1600 34 sets set NNS cord-010119-t1x9gknd 1600 35 by by IN cord-010119-t1x9gknd 1600 36 molecular molecular JJ cord-010119-t1x9gknd 1600 37 attribute attribute NN cord-010119-t1x9gknd 1600 38 patterns pattern NNS cord-010119-t1x9gknd 1600 39 . . . cord-010119-t1x9gknd 1601 1 Study Study NNP cord-010119-t1x9gknd 1601 2 Design Design NNP cord-010119-t1x9gknd 1601 3 / / SYM cord-010119-t1x9gknd 1601 4 Method method NN cord-010119-t1x9gknd 1601 5 : : : cord-010119-t1x9gknd 1602 1 Molecular molecular JJ cord-010119-t1x9gknd 1602 2 Sieving Sieving NNP cord-010119-t1x9gknd 1602 3 is be VBZ cord-010119-t1x9gknd 1602 4 a a DT cord-010119-t1x9gknd 1602 5 special special JJ cord-010119-t1x9gknd 1602 6 format format NN cord-010119-t1x9gknd 1602 7 of of IN cord-010119-t1x9gknd 1602 8 LeanSequencing LeanSequencing NNP cord-010119-t1x9gknd 1602 9 , , , cord-010119-t1x9gknd 1602 10 a a DT cord-010119-t1x9gknd 1602 11 proprietary proprietary JJ cord-010119-t1x9gknd 1602 12 process process NN cord-010119-t1x9gknd 1602 13 that that WDT cord-010119-t1x9gknd 1602 14 permits permit VBZ cord-010119-t1x9gknd 1602 15 the the DT cord-010119-t1x9gknd 1602 16 simultaneous simultaneous JJ cord-010119-t1x9gknd 1602 17 analysis analysis NN cord-010119-t1x9gknd 1602 18 of of IN cord-010119-t1x9gknd 1602 19 up up IN cord-010119-t1x9gknd 1602 20 to to TO cord-010119-t1x9gknd 1602 21 four four CD cord-010119-t1x9gknd 1602 22 samples sample NNS cord-010119-t1x9gknd 1602 23 for for IN cord-010119-t1x9gknd 1602 24 alleles allele NNS cord-010119-t1x9gknd 1602 25 encoding encode VBG cord-010119-t1x9gknd 1602 26 401 401 CD cord-010119-t1x9gknd 1602 27 RBC RBC NNP cord-010119-t1x9gknd 1602 28 antigens antigen NNS cord-010119-t1x9gknd 1602 29 in in IN cord-010119-t1x9gknd 1602 30 MNS MNS NNP cord-010119-t1x9gknd 1602 31 , , , cord-010119-t1x9gknd 1602 32 RHCE RHCE NNP cord-010119-t1x9gknd 1602 33 , , , cord-010119-t1x9gknd 1602 34 LU LU NNP cord-010119-t1x9gknd 1602 35 , , , cord-010119-t1x9gknd 1602 36 KEL KEL NNP cord-010119-t1x9gknd 1602 37 , , , cord-010119-t1x9gknd 1602 38 FY FY NNP cord-010119-t1x9gknd 1602 39 , , , cord-010119-t1x9gknd 1602 40 JK JK NNP cord-010119-t1x9gknd 1602 41 , , , cord-010119-t1x9gknd 1602 42 DI DI NNP cord-010119-t1x9gknd 1602 43 , , , cord-010119-t1x9gknd 1602 44 YT YT NNP cord-010119-t1x9gknd 1602 45 , , , cord-010119-t1x9gknd 1602 46 DO DO NNP cord-010119-t1x9gknd 1602 47 and and CC cord-010119-t1x9gknd 1602 48 CO CO NNP cord-010119-t1x9gknd 1602 49 , , , cord-010119-t1x9gknd 1602 50 including include VBG cord-010119-t1x9gknd 1602 51 the the DT cord-010119-t1x9gknd 1602 52 identification identification NN cord-010119-t1x9gknd 1602 53 of of IN cord-010119-t1x9gknd 1602 54 30 30 CD cord-010119-t1x9gknd 1602 55 RHCE RHCE NNP cord-010119-t1x9gknd 1602 56 alleles allele NNS cord-010119-t1x9gknd 1602 57 . . . cord-010119-t1x9gknd 1603 1 Molecular molecular JJ cord-010119-t1x9gknd 1603 2 Sieving Sieving NNP cord-010119-t1x9gknd 1603 3 extends extend VBZ cord-010119-t1x9gknd 1603 4 these these DT cord-010119-t1x9gknd 1603 5 capabilities capability NNS cord-010119-t1x9gknd 1603 6 to to IN cord-010119-t1x9gknd 1603 7 the the DT cord-010119-t1x9gknd 1603 8 analysis analysis NN cord-010119-t1x9gknd 1603 9 of of IN cord-010119-t1x9gknd 1603 10 pools pool NNS cord-010119-t1x9gknd 1603 11 to to TO cord-010119-t1x9gknd 1603 12 attain attain VB cord-010119-t1x9gknd 1603 13 large large JJ cord-010119-t1x9gknd 1603 14 scale scale NN cord-010119-t1x9gknd 1603 15 . . . cord-010119-t1x9gknd 1604 1 Thus thus RB cord-010119-t1x9gknd 1604 2 , , , cord-010119-t1x9gknd 1604 3 in in IN cord-010119-t1x9gknd 1604 4 one one CD cord-010119-t1x9gknd 1604 5 format format NN cord-010119-t1x9gknd 1604 6 of of IN cord-010119-t1x9gknd 1604 7 the the DT cord-010119-t1x9gknd 1604 8 process process NN cord-010119-t1x9gknd 1604 9 , , , cord-010119-t1x9gknd 1604 10 4 4 CD cord-010119-t1x9gknd 1604 11 * * SYM cord-010119-t1x9gknd 1604 12 4 4 CD cord-010119-t1x9gknd 1604 13 * * NFP cord-010119-t1x9gknd 1604 14 96 96 CD cord-010119-t1x9gknd 1604 15 samples sample NNS cord-010119-t1x9gknd 1604 16 are be VBP cord-010119-t1x9gknd 1604 17 accommodated accommodate VBN cord-010119-t1x9gknd 1604 18 in in IN cord-010119-t1x9gknd 1604 19 a a DT cord-010119-t1x9gknd 1604 20 single single JJ cord-010119-t1x9gknd 1604 21 run run NN cord-010119-t1x9gknd 1604 22 . . . cord-010119-t1x9gknd 1605 1 Following follow VBG cord-010119-t1x9gknd 1605 2 the the DT cord-010119-t1x9gknd 1605 3 completion completion NN cord-010119-t1x9gknd 1605 4 of of IN cord-010119-t1x9gknd 1605 5 the the DT cord-010119-t1x9gknd 1605 6 sieving sieving NN cord-010119-t1x9gknd 1605 7 step step NN cord-010119-t1x9gknd 1605 8 , , , cord-010119-t1x9gknd 1605 9 candidates candidate NNS cord-010119-t1x9gknd 1605 10 may may MD cord-010119-t1x9gknd 1605 11 be be VB cord-010119-t1x9gknd 1605 12 directly directly RB cord-010119-t1x9gknd 1605 13 assigned assign VBN cord-010119-t1x9gknd 1605 14 to to IN cord-010119-t1x9gknd 1605 15 requests request NNS cord-010119-t1x9gknd 1605 16 , , , cord-010119-t1x9gknd 1605 17 or or CC cord-010119-t1x9gknd 1605 18 may may MD cord-010119-t1x9gknd 1605 19 be be VB cord-010119-t1x9gknd 1605 20 selected select VBN cord-010119-t1x9gknd 1605 21 to to TO cord-010119-t1x9gknd 1605 22 enrich enrich VB cord-010119-t1x9gknd 1605 23 a a DT cord-010119-t1x9gknd 1605 24 subsequent subsequent JJ cord-010119-t1x9gknd 1605 25 profiling profiling NN cord-010119-t1x9gknd 1605 26 step step NN cord-010119-t1x9gknd 1605 27 for for IN cord-010119-t1x9gknd 1605 28 samples sample NNS cord-010119-t1x9gknd 1605 29 with with IN cord-010119-t1x9gknd 1605 30 rare rare JJ cord-010119-t1x9gknd 1605 31 or or CC cord-010119-t1x9gknd 1605 32 otherwise otherwise RB cord-010119-t1x9gknd 1605 33 desirable desirable JJ cord-010119-t1x9gknd 1605 34 attributes attribute NNS cord-010119-t1x9gknd 1605 35 . . . cord-010119-t1x9gknd 1606 1 Here here RB cord-010119-t1x9gknd 1606 2 , , , cord-010119-t1x9gknd 1606 3 MolecularSieving MolecularSieving NNP cord-010119-t1x9gknd 1606 4 was be VBD cord-010119-t1x9gknd 1606 5 used use VBN cord-010119-t1x9gknd 1606 6 to to TO cord-010119-t1x9gknd 1606 7 identify identify VB cord-010119-t1x9gknd 1606 8 suitable suitable JJ cord-010119-t1x9gknd 1606 9 donor donor NN cord-010119-t1x9gknd 1606 10 units unit NNS cord-010119-t1x9gknd 1606 11 for for IN cord-010119-t1x9gknd 1606 12 135 135 CD cord-010119-t1x9gknd 1606 13 sensitized sensitize VBN cord-010119-t1x9gknd 1606 14 sickle sickle NN cord-010119-t1x9gknd 1606 15 cell cell NN cord-010119-t1x9gknd 1606 16 anemia anemia NN cord-010119-t1x9gknd 1606 17 ( ( -LRB- cord-010119-t1x9gknd 1606 18 " " `` cord-010119-t1x9gknd 1606 19 SCA SCA NNP cord-010119-t1x9gknd 1606 20 " " '' cord-010119-t1x9gknd 1606 21 ) ) -RRB- cord-010119-t1x9gknd 1606 22 patients patient NNS cord-010119-t1x9gknd 1606 23 ( ( -LRB- cord-010119-t1x9gknd 1606 24 Tb1 tb1 NN cord-010119-t1x9gknd 1606 25 in in IN cord-010119-t1x9gknd 1606 26 Cas Cas NNP cord-010119-t1x9gknd 1606 27 - - HYPH cord-010119-t1x9gknd 1606 28 tro2002 tro2002 NNP cord-010119-t1x9gknd 1606 29 , , , cord-010119-t1x9gknd 1606 30 http://bit.ly/2oplxHr http://bit.ly/2oplxHr NNP cord-010119-t1x9gknd 1606 31 , , , cord-010119-t1x9gknd 1606 32 excluding exclude VBG cord-010119-t1x9gknd 1606 33 Le Le NNP cord-010119-t1x9gknd 1606 34 and and CC cord-010119-t1x9gknd 1606 35 e(variant e(variant NNP cord-010119-t1x9gknd 1606 36 ) ) -RRB- cord-010119-t1x9gknd 1606 37 and and CC cord-010119-t1x9gknd 1606 38 assuming assume VBG cord-010119-t1x9gknd 1606 39 1 1 CD cord-010119-t1x9gknd 1606 40 request request NN cord-010119-t1x9gknd 1606 41 per per IN cord-010119-t1x9gknd 1606 42 patient patient NN cord-010119-t1x9gknd 1606 43 ) ) -RRB- cord-010119-t1x9gknd 1606 44 , , , cord-010119-t1x9gknd 1606 45 presenting present VBG cord-010119-t1x9gknd 1606 46 with with IN cord-010119-t1x9gknd 1606 47 up up IN cord-010119-t1x9gknd 1606 48 to to TO cord-010119-t1x9gknd 1606 49 9 9 CD cord-010119-t1x9gknd 1606 50 allo allo NN cord-010119-t1x9gknd 1606 51 - - HYPH cord-010119-t1x9gknd 1606 52 antibodies antibody NNS cord-010119-t1x9gknd 1606 53 ( ( -LRB- cord-010119-t1x9gknd 1606 54 " " `` cord-010119-t1x9gknd 1606 55 Ab Ab NNP cord-010119-t1x9gknd 1606 56 " " '' cord-010119-t1x9gknd 1606 57 ) ) -RRB- cord-010119-t1x9gknd 1606 58 in in IN cord-010119-t1x9gknd 1606 59 multiple multiple JJ cord-010119-t1x9gknd 1606 60 combinations combination NNS cord-010119-t1x9gknd 1606 61 . . . cord-010119-t1x9gknd 1607 1 Proprietary proprietary JJ cord-010119-t1x9gknd 1607 2 " " `` cord-010119-t1x9gknd 1607 3 greedy greedy JJ cord-010119-t1x9gknd 1607 4 " " '' cord-010119-t1x9gknd 1607 5 algorithms algorithm NNS cord-010119-t1x9gknd 1607 6 were be VBD cord-010119-t1x9gknd 1607 7 invoked invoke VBN cord-010119-t1x9gknd 1607 8 to to TO cord-010119-t1x9gknd 1607 9 optimally optimally RB cord-010119-t1x9gknd 1607 10 pair pair VB cord-010119-t1x9gknd 1607 11 candidate candidate NN cord-010119-t1x9gknd 1607 12 units unit NNS cord-010119-t1x9gknd 1607 13 with with IN cord-010119-t1x9gknd 1607 14 requests request NNS cord-010119-t1x9gknd 1607 15 . . . cord-010119-t1x9gknd 1608 1 Results result NNS cord-010119-t1x9gknd 1608 2 / / SYM cord-010119-t1x9gknd 1608 3 Finding finding NN cord-010119-t1x9gknd 1608 4 : : : cord-010119-t1x9gknd 1609 1 Sieving sieve VBG cord-010119-t1x9gknd 1609 2 of of IN cord-010119-t1x9gknd 1609 3 only only RB cord-010119-t1x9gknd 1609 4 1 1 CD cord-010119-t1x9gknd 1609 5 = = SYM cord-010119-t1x9gknd 1609 6 2 2 CD cord-010119-t1x9gknd 1609 7 plate plate NN cord-010119-t1x9gknd 1609 8 holding hold VBG cord-010119-t1x9gknd 1609 9 4 4 CD cord-010119-t1x9gknd 1609 10 * * NFP cord-010119-t1x9gknd 1609 11 48 48 CD cord-010119-t1x9gknd 1609 12 candidate candidate NN cord-010119-t1x9gknd 1609 13 units unit NNS cord-010119-t1x9gknd 1609 14 from from IN cord-010119-t1x9gknd 1609 15 actual actual JJ cord-010119-t1x9gknd 1609 16 black black JJ cord-010119-t1x9gknd 1609 17 donors donor NNS cord-010119-t1x9gknd 1609 18 , , , cord-010119-t1x9gknd 1609 19 followed follow VBN cord-010119-t1x9gknd 1609 20 by by IN cord-010119-t1x9gknd 1609 21 profiling profile VBG cord-010119-t1x9gknd 1609 22 of of IN cord-010119-t1x9gknd 1609 23 44 44 CD cord-010119-t1x9gknd 1609 24 samples sample NNS cord-010119-t1x9gknd 1609 25 selected select VBN cord-010119-t1x9gknd 1609 26 to to TO cord-010119-t1x9gknd 1609 27 enrich enrich VB cord-010119-t1x9gknd 1609 28 for for IN cord-010119-t1x9gknd 1609 29 " " `` cord-010119-t1x9gknd 1609 30 e e NNP cord-010119-t1x9gknd 1609 31 Neg Neg NNP cord-010119-t1x9gknd 1609 32 " " '' cord-010119-t1x9gknd 1609 33 and and CC cord-010119-t1x9gknd 1609 34 " " `` cord-010119-t1x9gknd 1609 35 c c NNP cord-010119-t1x9gknd 1609 36 Neg Neg NNP cord-010119-t1x9gknd 1609 37 " " '' cord-010119-t1x9gknd 1609 38 and and CC cord-010119-t1x9gknd 1609 39 " " `` cord-010119-t1x9gknd 1609 40 C c NN cord-010119-t1x9gknd 1609 41 - - HYPH cord-010119-t1x9gknd 1609 42 E e NN cord-010119-t1x9gknd 1609 43 - - HYPH cord-010119-t1x9gknd 1609 44 K K NNP cord-010119-t1x9gknd 1609 45 - - HYPH cord-010119-t1x9gknd 1609 46 Fya Fya NNP cord-010119-t1x9gknd 1609 47 Neg Neg NNP cord-010119-t1x9gknd 1609 48 " " '' cord-010119-t1x9gknd 1609 49 , , , cord-010119-t1x9gknd 1609 50 produced produce VBD cord-010119-t1x9gknd 1609 51 assignments assignment NNS cord-010119-t1x9gknd 1609 52 for for IN cord-010119-t1x9gknd 1609 53 127 127 CD cord-010119-t1x9gknd 1609 54 of of IN cord-010119-t1x9gknd 1609 55 135 135 CD cord-010119-t1x9gknd 1609 56 requests request NNS cord-010119-t1x9gknd 1609 57 ( ( -LRB- cord-010119-t1x9gknd 1609 58 594.1 594.1 CD cord-010119-t1x9gknd 1609 59 % % NN cord-010119-t1x9gknd 1609 60 ) ) -RRB- cord-010119-t1x9gknd 1609 61 , , , cord-010119-t1x9gknd 1609 62 as as IN cord-010119-t1x9gknd 1609 63 indicated indicate VBN cord-010119-t1x9gknd 1609 64 by by IN cord-010119-t1x9gknd 1609 65 colors color NNS cord-010119-t1x9gknd 1609 66 , , , cord-010119-t1x9gknd 1609 67 and and CC cord-010119-t1x9gknd 1609 68 shown show VBN cord-010119-t1x9gknd 1609 69 in in IN cord-010119-t1x9gknd 1609 70 the the DT cord-010119-t1x9gknd 1609 71 row row NN cord-010119-t1x9gknd 1609 72 " " `` cord-010119-t1x9gknd 1609 73 assigned assign VBN cord-010119-t1x9gknd 1609 74 " " '' cord-010119-t1x9gknd 1609 75 below below RB cord-010119-t1x9gknd 1609 76 : : : cord-010119-t1x9gknd 1610 1 Thus thus RB cord-010119-t1x9gknd 1610 2 , , , cord-010119-t1x9gknd 1610 3 the the DT cord-010119-t1x9gknd 1610 4 number number NN cord-010119-t1x9gknd 1610 5 of of IN cord-010119-t1x9gknd 1610 6 assignments assignment NNS cord-010119-t1x9gknd 1610 7 substantially substantially RB cord-010119-t1x9gknd 1610 8 exceeded exceed VBD cord-010119-t1x9gknd 1610 9 the the DT cord-010119-t1x9gknd 1610 10 number number NN cord-010119-t1x9gknd 1610 11 of of IN cord-010119-t1x9gknd 1610 12 wells well NNS cord-010119-t1x9gknd 1610 13 processed process VBN cord-010119-t1x9gknd 1610 14 . . . cord-010119-t1x9gknd 1611 1 Moreover moreover RB cord-010119-t1x9gknd 1611 2 , , , cord-010119-t1x9gknd 1611 3 the the DT cord-010119-t1x9gknd 1611 4 remaining remain VBG cord-010119-t1x9gknd 1611 5 66 66 CD cord-010119-t1x9gknd 1611 6 pooled pool VBN cord-010119-t1x9gknd 1611 7 samples sample NNS cord-010119-t1x9gknd 1611 8 produced produce VBD cord-010119-t1x9gknd 1611 9 44 44 CD cord-010119-t1x9gknd 1611 10 additional additional JJ cord-010119-t1x9gknd 1611 11 assignments assignment NNS cord-010119-t1x9gknd 1611 12 to to IN cord-010119-t1x9gknd 1611 13 a a DT cord-010119-t1x9gknd 1611 14 second second JJ cord-010119-t1x9gknd 1611 15 set set NN cord-010119-t1x9gknd 1611 16 of of IN cord-010119-t1x9gknd 1611 17 135 135 CD cord-010119-t1x9gknd 1611 18 requests request NNS cord-010119-t1x9gknd 1611 19 , , , cord-010119-t1x9gknd 1611 20 for for IN cord-010119-t1x9gknd 1611 21 a a DT cord-010119-t1x9gknd 1611 22 total total NN cord-010119-t1x9gknd 1611 23 of of IN cord-010119-t1x9gknd 1611 24 171 171 CD cord-010119-t1x9gknd 1611 25 assignments assignment NNS cord-010119-t1x9gknd 1611 26 from from IN cord-010119-t1x9gknd 1611 27 only only RB cord-010119-t1x9gknd 1611 28 92 92 CD cord-010119-t1x9gknd 1611 29 wells well NNS cord-010119-t1x9gknd 1611 30 . . . cord-010119-t1x9gknd 1612 1 In in IN cord-010119-t1x9gknd 1612 2 another another DT cord-010119-t1x9gknd 1612 3 scenario scenario NN cord-010119-t1x9gknd 1612 4 , , , cord-010119-t1x9gknd 1612 5 sieving sieving NN cord-010119-t1x9gknd 1612 6 of of IN cord-010119-t1x9gknd 1612 7 a a DT cord-010119-t1x9gknd 1612 8 full full JJ cord-010119-t1x9gknd 1612 9 plate plate NN cord-010119-t1x9gknd 1612 10 of of IN cord-010119-t1x9gknd 1612 11 4 4 CD cord-010119-t1x9gknd 1612 12 * * NFP cord-010119-t1x9gknd 1612 13 96 96 CD cord-010119-t1x9gknd 1612 14 samples sample NNS cord-010119-t1x9gknd 1612 15 , , , cord-010119-t1x9gknd 1612 16 produced produce VBD cord-010119-t1x9gknd 1612 17 $ $ $ cord-010119-t1x9gknd 1612 18 250 250 CD cord-010119-t1x9gknd 1612 19 assignments assignment NNS cord-010119-t1x9gknd 1612 20 for for IN cord-010119-t1x9gknd 1612 21 two two CD cord-010119-t1x9gknd 1612 22 successive successive JJ cord-010119-t1x9gknd 1612 23 batches batch NNS cord-010119-t1x9gknd 1612 24 of of IN cord-010119-t1x9gknd 1612 25 271 271 CD cord-010119-t1x9gknd 1612 26 requests request NNS cord-010119-t1x9gknd 1612 27 from from IN cord-010119-t1x9gknd 1612 28 SCA SCA NNP cord-010119-t1x9gknd 1612 29 patients patient NNS cord-010119-t1x9gknd 1612 30 , , , cord-010119-t1x9gknd 1612 31 a a DT cord-010119-t1x9gknd 1612 32 yield yield NN cord-010119-t1x9gknd 1612 33 exceeding exceed VBG cord-010119-t1x9gknd 1612 34 2.5x 2.5x CD cord-010119-t1x9gknd 1612 35 . . . cord-010119-t1x9gknd 1613 1 Sieving sieve VBG cord-010119-t1x9gknd 1613 2 alone alone RB cord-010119-t1x9gknd 1613 3 typically typically RB cord-010119-t1x9gknd 1613 4 fills fill VBZ cord-010119-t1x9gknd 1613 5 65 65 CD cord-010119-t1x9gknd 1613 6 - - SYM cord-010119-t1x9gknd 1613 7 75 75 CD cord-010119-t1x9gknd 1613 8 % % NN cord-010119-t1x9gknd 1613 9 of of IN cord-010119-t1x9gknd 1613 10 requests request NNS cord-010119-t1x9gknd 1613 11 of of IN cord-010119-t1x9gknd 1613 12 moderate moderate JJ cord-010119-t1x9gknd 1613 13 complexity complexity NN cord-010119-t1x9gknd 1613 14 ( ( -LRB- cord-010119-t1x9gknd 1613 15 5 5 CD cord-010119-t1x9gknd 1613 16 Ab ab NN cord-010119-t1x9gknd 1613 17 ) ) -RRB- cord-010119-t1x9gknd 1613 18 . . . cord-010119-t1x9gknd 1614 1 Conclusion conclusion NN cord-010119-t1x9gknd 1614 2 : : : cord-010119-t1x9gknd 1614 3 MolecularSieving MolecularSieving NNP cord-010119-t1x9gknd 1614 4 , , , cord-010119-t1x9gknd 1614 5 by by IN cord-010119-t1x9gknd 1614 6 widening widen VBG cord-010119-t1x9gknd 1614 7 the the DT cord-010119-t1x9gknd 1614 8 " " `` cord-010119-t1x9gknd 1614 9 funnel funnel NN cord-010119-t1x9gknd 1614 10 " " '' cord-010119-t1x9gknd 1614 11 while while IN cord-010119-t1x9gknd 1614 12 focusing focus VBG cord-010119-t1x9gknd 1614 13 the the DT cord-010119-t1x9gknd 1614 14 search search NN cord-010119-t1x9gknd 1614 15 for for IN cord-010119-t1x9gknd 1614 16 candidate candidate NN cord-010119-t1x9gknd 1614 17 donor donor NN cord-010119-t1x9gknd 1614 18 units unit NNS cord-010119-t1x9gknd 1614 19 , , , cord-010119-t1x9gknd 1614 20 attains attain VBZ cord-010119-t1x9gknd 1614 21 a a DT cord-010119-t1x9gknd 1614 22 new new JJ cord-010119-t1x9gknd 1614 23 level level NN cord-010119-t1x9gknd 1614 24 of of IN cord-010119-t1x9gknd 1614 25 efficiency efficiency NN cord-010119-t1x9gknd 1614 26 in in IN cord-010119-t1x9gknd 1614 27 procuring procure VBG cord-010119-t1x9gknd 1614 28 suitable suitable JJ cord-010119-t1x9gknd 1614 29 units unit NNS cord-010119-t1x9gknd 1614 30 for for IN cord-010119-t1x9gknd 1614 31 patients patient NNS cord-010119-t1x9gknd 1614 32 with with IN cord-010119-t1x9gknd 1614 33 hemoglobinopathies hemoglobinopathy NNS cord-010119-t1x9gknd 1614 34 . . . cord-010119-t1x9gknd 1615 1 Molecular molecular JJ cord-010119-t1x9gknd 1615 2 Sieving Sieving NNP cord-010119-t1x9gknd 1615 3 for for IN cord-010119-t1x9gknd 1615 4 Identifying identify VBG cord-010119-t1x9gknd 1615 5 Red Red NNP cord-010119-t1x9gknd 1615 6 Blood Blood NNP cord-010119-t1x9gknd 1615 7 Cells cell NNS cord-010119-t1x9gknd 1615 8 with with IN cord-010119-t1x9gknd 1615 9 Special Special NNP cord-010119-t1x9gknd 1615 10 Phenotype Phenotype NNP cord-010119-t1x9gknd 1615 11 Attributes attribute VBZ cord-010119-t1x9gknd 1615 12 Kristopher Kristopher NNP cord-010119-t1x9gknd 1615 13 Fernandez Fernandez NNP cord-010119-t1x9gknd 1615 14 1 1 CD cord-010119-t1x9gknd 1615 15 , , , cord-010119-t1x9gknd 1615 16 Monica Monica NNP cord-010119-t1x9gknd 1615 17 Kalvelage Kalvelage NNP cord-010119-t1x9gknd 1615 18 2 2 CD cord-010119-t1x9gknd 1615 19 , , , cord-010119-t1x9gknd 1615 20 Ghazala Ghazala NNP cord-010119-t1x9gknd 1615 21 Hashmi Hashmi NNP cord-010119-t1x9gknd 1616 1 * * NFP cord-010119-t1x9gknd 1616 2 1 1 CD cord-010119-t1x9gknd 1616 3 and and CC cord-010119-t1x9gknd 1616 4 Michael Michael NNP cord-010119-t1x9gknd 1616 5 Seul Seul NNP cord-010119-t1x9gknd 1616 6 1 1 CD cord-010119-t1x9gknd 1616 7 . . . cord-010119-t1x9gknd 1617 1 1 1 CD cord-010119-t1x9gknd 1617 2 BioMolecular BioMolecular NNP cord-010119-t1x9gknd 1617 3 Analytics Analytics NNP cord-010119-t1x9gknd 1617 4 , , , cord-010119-t1x9gknd 1617 5 2 2 CD cord-010119-t1x9gknd 1617 6 LifeShare LifeShare NNP cord-010119-t1x9gknd 1617 7 Blood Blood NNP cord-010119-t1x9gknd 1617 8 Centers Centers NNPS cord-010119-t1x9gknd 1617 9 Background Background NNP cord-010119-t1x9gknd 1617 10 / / SYM cord-010119-t1x9gknd 1617 11 Case Case NNP cord-010119-t1x9gknd 1617 12 Studies Studies NNPS cord-010119-t1x9gknd 1617 13 : : : cord-010119-t1x9gknd 1618 1 Providing provide VBG cord-010119-t1x9gknd 1618 2 transfusion transfusion NN cord-010119-t1x9gknd 1618 3 support support NN cord-010119-t1x9gknd 1618 4 to to IN cord-010119-t1x9gknd 1618 5 patients patient NNS cord-010119-t1x9gknd 1618 6 with with IN cord-010119-t1x9gknd 1618 7 sickle sickle NN cord-010119-t1x9gknd 1618 8 cell cell NN cord-010119-t1x9gknd 1618 9 anemia anemia NN cord-010119-t1x9gknd 1618 10 and and CC cord-010119-t1x9gknd 1618 11 other other JJ cord-010119-t1x9gknd 1618 12 hemoglobinopathies hemoglobinopathy NNS cord-010119-t1x9gknd 1618 13 remains remain VBZ cord-010119-t1x9gknd 1618 14 a a DT cord-010119-t1x9gknd 1618 15 challenging challenging JJ cord-010119-t1x9gknd 1618 16 logistical logistical JJ cord-010119-t1x9gknd 1618 17 task task NN cord-010119-t1x9gknd 1618 18 that that WDT cord-010119-t1x9gknd 1618 19 must must MD cord-010119-t1x9gknd 1618 20 accommodate accommodate VB cord-010119-t1x9gknd 1618 21 pre pre JJ cord-010119-t1x9gknd 1618 22 - - JJ cord-010119-t1x9gknd 1618 23 existing existing JJ cord-010119-t1x9gknd 1618 24 allo allo NN cord-010119-t1x9gknd 1618 25 - - HYPH cord-010119-t1x9gknd 1618 26 antibodies antibody NNS cord-010119-t1x9gknd 1618 27 in in IN cord-010119-t1x9gknd 1618 28 multiple multiple JJ cord-010119-t1x9gknd 1618 29 combinations combination NNS cord-010119-t1x9gknd 1618 30 preferably preferably RB cord-010119-t1x9gknd 1618 31 while while IN cord-010119-t1x9gknd 1618 32 minimizing minimize VBG cord-010119-t1x9gknd 1618 33 the the DT cord-010119-t1x9gknd 1618 34 risk risk NN cord-010119-t1x9gknd 1618 35 of of IN cord-010119-t1x9gknd 1618 36 ( ( -LRB- cord-010119-t1x9gknd 1618 37 continued continued JJ cord-010119-t1x9gknd 1618 38 ) ) -RRB- cord-010119-t1x9gknd 1618 39 transfusion transfusion NN cord-010119-t1x9gknd 1618 40 - - HYPH cord-010119-t1x9gknd 1618 41 related relate VBN cord-010119-t1x9gknd 1618 42 sensitization sensitization NN cord-010119-t1x9gknd 1618 43 . . . cord-010119-t1x9gknd 1619 1 The the DT cord-010119-t1x9gknd 1619 2 allelic allelic JJ cord-010119-t1x9gknd 1619 3 diversity diversity NN cord-010119-t1x9gknd 1619 4 of of IN cord-010119-t1x9gknd 1619 5 the the DT cord-010119-t1x9gknd 1619 6 predominantly predominantly RB cord-010119-t1x9gknd 1619 7 black black JJ cord-010119-t1x9gknd 1619 8 patient patient NN cord-010119-t1x9gknd 1619 9 population population NN cord-010119-t1x9gknd 1619 10 , , , cord-010119-t1x9gknd 1619 11 especially especially RB cord-010119-t1x9gknd 1619 12 at at IN cord-010119-t1x9gknd 1619 13 the the DT cord-010119-t1x9gknd 1619 14 RH RH NNP cord-010119-t1x9gknd 1619 15 locus locus NN cord-010119-t1x9gknd 1619 16 which which WDT cord-010119-t1x9gknd 1619 17 encodes encode VBZ cord-010119-t1x9gknd 1619 18 a a DT cord-010119-t1x9gknd 1619 19 variety variety NN cord-010119-t1x9gknd 1619 20 of of IN cord-010119-t1x9gknd 1619 21 " " `` cord-010119-t1x9gknd 1619 22 partial partial JJ cord-010119-t1x9gknd 1619 23 " " '' cord-010119-t1x9gknd 1619 24 phenotypes phenotype NNS cord-010119-t1x9gknd 1619 25 further further RB cord-010119-t1x9gknd 1619 26 complicates complicate VBZ cord-010119-t1x9gknd 1619 27 the the DT cord-010119-t1x9gknd 1619 28 problem problem NN cord-010119-t1x9gknd 1619 29 ( ( -LRB- cord-010119-t1x9gknd 1619 30 Chou2013 Chou2013 NNP cord-010119-t1x9gknd 1619 31 http://bit http://bit NNP cord-010119-t1x9gknd 1619 32 . . . cord-010119-t1x9gknd 1620 1 ly/2ppVfEq ly/2ppVfEq NNP cord-010119-t1x9gknd 1620 2 ) ) -RRB- cord-010119-t1x9gknd 1620 3 . . . cord-010119-t1x9gknd 1621 1 Study Study NNP cord-010119-t1x9gknd 1621 2 Design Design NNP cord-010119-t1x9gknd 1621 3 / / SYM cord-010119-t1x9gknd 1621 4 Method method NN cord-010119-t1x9gknd 1621 5 : : : cord-010119-t1x9gknd 1622 1 Molecular molecular JJ cord-010119-t1x9gknd 1622 2 Sieving Sieving NNP cord-010119-t1x9gknd 1622 3 is be VBZ cord-010119-t1x9gknd 1622 4 a a DT cord-010119-t1x9gknd 1622 5 proprietary proprietary JJ cord-010119-t1x9gknd 1622 6 new new JJ cord-010119-t1x9gknd 1622 7 process process NN cord-010119-t1x9gknd 1622 8 that that WDT cord-010119-t1x9gknd 1622 9 , , , cord-010119-t1x9gknd 1622 10 in in IN cord-010119-t1x9gknd 1622 11 order order NN cord-010119-t1x9gknd 1622 12 to to TO cord-010119-t1x9gknd 1622 13 rapidly rapidly RB cord-010119-t1x9gknd 1622 14 probe probe VB cord-010119-t1x9gknd 1622 15 candidate candidate NN cord-010119-t1x9gknd 1622 16 donor donor NN cord-010119-t1x9gknd 1622 17 units unit NNS cord-010119-t1x9gknd 1622 18 in in IN cord-010119-t1x9gknd 1622 19 large large JJ cord-010119-t1x9gknd 1622 20 numbers number NNS cord-010119-t1x9gknd 1622 21 for for IN cord-010119-t1x9gknd 1622 22 multiple multiple JJ cord-010119-t1x9gknd 1622 23 phenotype phenotype NN cord-010119-t1x9gknd 1622 24 patterns pattern NNS cord-010119-t1x9gknd 1622 25 , , , cord-010119-t1x9gknd 1622 26 permits permit VBZ cord-010119-t1x9gknd 1622 27 the the DT cord-010119-t1x9gknd 1622 28 analysis analysis NN cord-010119-t1x9gknd 1622 29 of of IN cord-010119-t1x9gknd 1622 30 pools pool NNS cord-010119-t1x9gknd 1622 31 and and CC cord-010119-t1x9gknd 1622 32 pools pool NNS cord-010119-t1x9gknd 1622 33 of of IN cord-010119-t1x9gknd 1622 34 pools pool NNS cord-010119-t1x9gknd 1622 35 of of IN cord-010119-t1x9gknd 1622 36 samples sample NNS cord-010119-t1x9gknd 1622 37 for for IN cord-010119-t1x9gknd 1622 38 a a DT cord-010119-t1x9gknd 1622 39 multiplicity multiplicity NN cord-010119-t1x9gknd 1622 40 of of IN cord-010119-t1x9gknd 1622 41 alleles allele NNS cord-010119-t1x9gknd 1622 42 ( ( -LRB- cord-010119-t1x9gknd 1622 43 including include VBG cord-010119-t1x9gknd 1622 44 30 30 CD cord-010119-t1x9gknd 1622 45 at at IN cord-010119-t1x9gknd 1622 46 the the DT cord-010119-t1x9gknd 1622 47 RHCE RHCE NNP cord-010119-t1x9gknd 1622 48 locus locus NN cord-010119-t1x9gknd 1622 49 ) ) -RRB- cord-010119-t1x9gknd 1622 50 that that WDT cord-010119-t1x9gknd 1622 51 encode encode VBP cord-010119-t1x9gknd 1622 52 401 401 CD cord-010119-t1x9gknd 1622 53 MNS MNS NNP cord-010119-t1x9gknd 1622 54 , , , cord-010119-t1x9gknd 1622 55 RH RH NNP cord-010119-t1x9gknd 1622 56 , , , cord-010119-t1x9gknd 1622 57 LU LU NNP cord-010119-t1x9gknd 1622 58 , , , cord-010119-t1x9gknd 1622 59 KEL KEL NNP cord-010119-t1x9gknd 1622 60 , , , cord-010119-t1x9gknd 1622 61 FY FY NNP cord-010119-t1x9gknd 1622 62 , , , cord-010119-t1x9gknd 1622 63 JK JK NNP cord-010119-t1x9gknd 1622 64 , , , cord-010119-t1x9gknd 1622 65 DI DI NNP cord-010119-t1x9gknd 1622 66 , , , cord-010119-t1x9gknd 1622 67 YT YT NNP cord-010119-t1x9gknd 1622 68 , , , cord-010119-t1x9gknd 1622 69 DO DO NNP cord-010119-t1x9gknd 1622 70 and and CC cord-010119-t1x9gknd 1622 71 CO CO NNP cord-010119-t1x9gknd 1622 72 antigens antigen NNS cord-010119-t1x9gknd 1622 73 . . . cord-010119-t1x9gknd 1623 1 Based base VBN cord-010119-t1x9gknd 1623 2 on on IN cord-010119-t1x9gknd 1623 3 sieving sieving NN cord-010119-t1x9gknd 1623 4 , , , cord-010119-t1x9gknd 1623 5 samples sample NNS cord-010119-t1x9gknd 1623 6 may may MD cord-010119-t1x9gknd 1623 7 be be VB cord-010119-t1x9gknd 1623 8 grouped group VBN cord-010119-t1x9gknd 1623 9 by by IN cord-010119-t1x9gknd 1623 10 molecular molecular JJ cord-010119-t1x9gknd 1623 11 attribute attribute NN cord-010119-t1x9gknd 1623 12 patterns pattern NNS cord-010119-t1x9gknd 1623 13 ranging range VBG cord-010119-t1x9gknd 1623 14 from from IN cord-010119-t1x9gknd 1623 15 single single JJ cord-010119-t1x9gknd 1623 16 " " `` cord-010119-t1x9gknd 1623 17 Ag2 ag2 NN cord-010119-t1x9gknd 1623 18 " " '' cord-010119-t1x9gknd 1623 19 ( ( -LRB- cord-010119-t1x9gknd 1623 20 e.g. e.g. RB cord-010119-t1x9gknd 1623 21 E2,C2,e2,c2 e2,c2,e2,c2 NN cord-010119-t1x9gknd 1623 22 ) ) -RRB- cord-010119-t1x9gknd 1623 23 to to IN cord-010119-t1x9gknd 1623 24 specific specific JJ cord-010119-t1x9gknd 1623 25 combinations combination NNS cord-010119-t1x9gknd 1623 26 of of IN cord-010119-t1x9gknd 1623 27 " " `` cord-010119-t1x9gknd 1623 28 Ag2 ag2 NN cord-010119-t1x9gknd 1623 29 " " '' cord-010119-t1x9gknd 1623 30 ( ( -LRB- cord-010119-t1x9gknd 1623 31 e.g. e.g. IN cord-010119-t1x9gknd 1623 32 C2E2K2Fya2 c2e2k2fya2 JJ cord-010119-t1x9gknd 1623 33 and and CC cord-010119-t1x9gknd 1623 34 C2E2Jsa2 C2E2Jsa2 NNP cord-010119-t1x9gknd 1623 35 ) ) -RRB- cord-010119-t1x9gknd 1623 36 or or CC cord-010119-t1x9gknd 1623 37 combinations combination NNS cord-010119-t1x9gknd 1623 38 of of IN cord-010119-t1x9gknd 1623 39 alleles allele NNS cord-010119-t1x9gknd 1623 40 such such JJ cord-010119-t1x9gknd 1623 41 as as IN cord-010119-t1x9gknd 1623 42 those those DT cord-010119-t1x9gknd 1623 43 encoding encode VBG cord-010119-t1x9gknd 1623 44 partial partial JJ cord-010119-t1x9gknd 1623 45 RH RH NNP cord-010119-t1x9gknd 1623 46 phenotypes phenotype NNS cord-010119-t1x9gknd 1623 47 . . . cord-010119-t1x9gknd 1624 1 Sieving Sieving NNP cord-010119-t1x9gknd 1624 2 , , , cord-010119-t1x9gknd 1624 3 optionally optionally RB cord-010119-t1x9gknd 1624 4 , , , cord-010119-t1x9gknd 1624 5 may may MD cord-010119-t1x9gknd 1624 6 be be VB cord-010119-t1x9gknd 1624 7 followed follow VBN cord-010119-t1x9gknd 1624 8 by by IN cord-010119-t1x9gknd 1624 9 profiling profiling NN cord-010119-t1x9gknd 1624 10 of of IN cord-010119-t1x9gknd 1624 11 samples sample NNS cord-010119-t1x9gknd 1624 12 selected select VBN cord-010119-t1x9gknd 1624 13 for for IN cord-010119-t1x9gknd 1624 14 desirable desirable JJ cord-010119-t1x9gknd 1624 15 attribute attribute NN cord-010119-t1x9gknd 1624 16 patterns pattern NNS cord-010119-t1x9gknd 1624 17 . . . cord-010119-t1x9gknd 1625 1 Genomic genomic JJ cord-010119-t1x9gknd 1625 2 DNA dna NN cord-010119-t1x9gknd 1625 3 from from IN cord-010119-t1x9gknd 1625 4 384 384 CD cord-010119-t1x9gknd 1625 5 ( ( -LRB- cord-010119-t1x9gknd 1625 6 predominantly predominantly RB cord-010119-t1x9gknd 1625 7 ) ) -RRB- cord-010119-t1x9gknd 1625 8 black black JJ cord-010119-t1x9gknd 1625 9 donors donor NNS cord-010119-t1x9gknd 1625 10 , , , cord-010119-t1x9gknd 1625 11 independently independently RB cord-010119-t1x9gknd 1625 12 genotyped genotype VBN cord-010119-t1x9gknd 1625 13 by by IN cord-010119-t1x9gknd 1625 14 one one CD cord-010119-t1x9gknd 1625 15 of of IN cord-010119-t1x9gknd 1625 16 two two CD cord-010119-t1x9gknd 1625 17 commercial commercial JJ cord-010119-t1x9gknd 1625 18 methods method NNS cord-010119-t1x9gknd 1625 19 were be VBD cord-010119-t1x9gknd 1625 20 provided provide VBN cord-010119-t1x9gknd 1625 21 by by IN cord-010119-t1x9gknd 1625 22 LBC LBC NNP cord-010119-t1x9gknd 1625 23 . . . cord-010119-t1x9gknd 1626 1 At at IN cord-010119-t1x9gknd 1626 2 bmx bmx NNP cord-010119-t1x9gknd 1626 3 , , , cord-010119-t1x9gknd 1626 4 96 96 CD cord-010119-t1x9gknd 1626 5 pools pool NNS cord-010119-t1x9gknd 1626 6 were be VBD cord-010119-t1x9gknd 1626 7 prepared prepare VBN cord-010119-t1x9gknd 1626 8 prior prior RB cord-010119-t1x9gknd 1626 9 to to IN cord-010119-t1x9gknd 1626 10 amplification amplification NN cord-010119-t1x9gknd 1626 11 , , , cord-010119-t1x9gknd 1626 12 and and CC cord-010119-t1x9gknd 1626 13 analyzed analyze VBN cord-010119-t1x9gknd 1626 14 by by IN cord-010119-t1x9gknd 1626 15 a a DT cord-010119-t1x9gknd 1626 16 novel novel NN cord-010119-t1x9gknd 1626 17 LeanSequencing LeanSequencing NNP cord-010119-t1x9gknd 1626 18 method method NN cord-010119-t1x9gknd 1626 19 . . . cord-010119-t1x9gknd 1627 1 Results/ Results/ . cord-010119-t1x9gknd 1628 1 Finding finding NN cord-010119-t1x9gknd 1628 2 : : : cord-010119-t1x9gknd 1629 1 All all DT cord-010119-t1x9gknd 1629 2 pool pool NN cord-010119-t1x9gknd 1629 3 genotypes genotype NNS cord-010119-t1x9gknd 1629 4 were be VBD cord-010119-t1x9gknd 1629 5 consistent consistent JJ cord-010119-t1x9gknd 1629 6 with with IN cord-010119-t1x9gknd 1629 7 available available JJ cord-010119-t1x9gknd 1629 8 individual individual JJ cord-010119-t1x9gknd 1629 9 sample sample NN cord-010119-t1x9gknd 1629 10 genotypes genotype NNS cord-010119-t1x9gknd 1629 11 . . . cord-010119-t1x9gknd 1630 1 Antigen antigen NN cord-010119-t1x9gknd 1630 2 patterns pattern NNS cord-010119-t1x9gknd 1630 3 of of IN cord-010119-t1x9gknd 1630 4 particular particular JJ cord-010119-t1x9gknd 1630 5 interest interest NN cord-010119-t1x9gknd 1630 6 included include VBD cord-010119-t1x9gknd 1630 7 two two CD cord-010119-t1x9gknd 1630 8 groups group NNS cord-010119-t1x9gknd 1630 9 , , , cord-010119-t1x9gknd 1630 10 namely namely RB cord-010119-t1x9gknd 1630 11 : : : cord-010119-t1x9gknd 1630 12 several several JJ cord-010119-t1x9gknd 1630 13 for for IN cord-010119-t1x9gknd 1630 14 which which WDT cord-010119-t1x9gknd 1630 15 pools pool NNS cord-010119-t1x9gknd 1630 16 were be VBD cord-010119-t1x9gknd 1630 17 homozygous homozygous JJ cord-010119-t1x9gknd 1630 18 and and CC cord-010119-t1x9gknd 1630 19 certain certain JJ cord-010119-t1x9gknd 1631 1 others other NNS cord-010119-t1x9gknd 1631 2 t t VBP cord-010119-t1x9gknd 1631 3 for for IN cord-010119-t1x9gknd 1631 4 which which WDT cord-010119-t1x9gknd 1631 5 pools pool NNS cord-010119-t1x9gknd 1631 6 were be VBD cord-010119-t1x9gknd 1631 7 heterozygous heterozygous JJ cord-010119-t1x9gknd 1631 8 . . . cord-010119-t1x9gknd 1632 1 Illustrative illustrative JJ cord-010119-t1x9gknd 1632 2 of of IN cord-010119-t1x9gknd 1632 3 the the DT cord-010119-t1x9gknd 1632 4 former former JJ cord-010119-t1x9gknd 1632 5 pattern pattern NN cord-010119-t1x9gknd 1632 6 type type NN cord-010119-t1x9gknd 1632 7 are be VBP cord-010119-t1x9gknd 1632 8 these these DT cord-010119-t1x9gknd 1632 9 : : : cord-010119-t1x9gknd 1632 10 Appropriate appropriate JJ cord-010119-t1x9gknd 1632 11 pool pool NN cord-010119-t1x9gknd 1632 12 queries query NNS cord-010119-t1x9gknd 1632 13 revealed reveal VBD cord-010119-t1x9gknd 1632 14 that that IN cord-010119-t1x9gknd 1632 15 sieving sieving NN cord-010119-t1x9gknd 1632 16 alone alone RB cord-010119-t1x9gknd 1632 17 identified identify VBN cord-010119-t1x9gknd 1632 18 , , , cord-010119-t1x9gknd 1632 19 among among IN cord-010119-t1x9gknd 1632 20 the the DT cord-010119-t1x9gknd 1632 21 124 124 CD cord-010119-t1x9gknd 1632 22 C2 C2 NNP cord-010119-t1x9gknd 1632 23 samples sample NNS cord-010119-t1x9gknd 1632 24 , , , cord-010119-t1x9gknd 1632 25 24 24 CD cord-010119-t1x9gknd 1632 26 that that WDT cord-010119-t1x9gknd 1632 27 were be VBD cord-010119-t1x9gknd 1632 28 also also RB cord-010119-t1x9gknd 1632 29 V2 v2 NN cord-010119-t1x9gknd 1632 30 and and CC cord-010119-t1x9gknd 1632 31 VS2 vs2 NN cord-010119-t1x9gknd 1632 32 and and CC cord-010119-t1x9gknd 1632 33 , , , cord-010119-t1x9gknd 1632 34 among among IN cord-010119-t1x9gknd 1632 35 the the DT cord-010119-t1x9gknd 1632 36 E2 E2 NNP cord-010119-t1x9gknd 1632 37 samples sample NNS cord-010119-t1x9gknd 1632 38 , , , cord-010119-t1x9gknd 1632 39 12 12 CD cord-010119-t1x9gknd 1632 40 that that WDT cord-010119-t1x9gknd 1632 41 were be VBD cord-010119-t1x9gknd 1632 42 also also RB cord-010119-t1x9gknd 1632 43 negative negative JJ cord-010119-t1x9gknd 1632 44 for for IN cord-010119-t1x9gknd 1632 45 any any DT cord-010119-t1x9gknd 1632 46 partial_e partial_e NNP cord-010119-t1x9gknd 1632 47 phenotype phenotype NN cord-010119-t1x9gknd 1632 48 . . . cord-010119-t1x9gknd 1633 1 Illustrative illustrative JJ cord-010119-t1x9gknd 1633 2 of of IN cord-010119-t1x9gknd 1633 3 the the DT cord-010119-t1x9gknd 1633 4 latter latter JJ cord-010119-t1x9gknd 1633 5 pattern pattern NN cord-010119-t1x9gknd 1633 6 type type NN cord-010119-t1x9gknd 1633 7 are be VBP cord-010119-t1x9gknd 1633 8 pools pool NNS cord-010119-t1x9gknd 1633 9 identified identify VBN cord-010119-t1x9gknd 1633 10 as as IN cord-010119-t1x9gknd 1633 11 heterozygous heterozygous JJ cord-010119-t1x9gknd 1633 12 ( ( -LRB- cord-010119-t1x9gknd 1633 13 " " `` cord-010119-t1x9gknd 1633 14 het het NNP cord-010119-t1x9gknd 1633 15 " " '' cord-010119-t1x9gknd 1633 16 ) ) -RRB- cord-010119-t1x9gknd 1633 17 for for IN cord-010119-t1x9gknd 1633 18 alleles allele NNS cord-010119-t1x9gknd 1633 19 encoding encode VBG cord-010119-t1x9gknd 1633 20 antigens antigen NNS cord-010119-t1x9gknd 1633 21 of of IN cord-010119-t1x9gknd 1633 22 high high JJ cord-010119-t1x9gknd 1633 23 or or CC cord-010119-t1x9gknd 1633 24 low low JJ cord-010119-t1x9gknd 1633 25 prevalence prevalence NN cord-010119-t1x9gknd 1633 26 . . . cord-010119-t1x9gknd 1634 1 By by IN cord-010119-t1x9gknd 1634 2 segregating segregate VBG cord-010119-t1x9gknd 1634 3 het het NN cord-010119-t1x9gknd 1634 4 pools pool NNS cord-010119-t1x9gknd 1634 5 into into IN cord-010119-t1x9gknd 1634 6 subpopulations subpopulation NNS cord-010119-t1x9gknd 1634 7 , , , cord-010119-t1x9gknd 1634 8 we -PRON- PRP cord-010119-t1x9gknd 1634 9 were be VBD cord-010119-t1x9gknd 1634 10 able able JJ cord-010119-t1x9gknd 1634 11 to to TO cord-010119-t1x9gknd 1634 12 select select VB cord-010119-t1x9gknd 1634 13 6 6 CD cord-010119-t1x9gknd 1634 14 specific specific JJ cord-010119-t1x9gknd 1634 15 " " `` cord-010119-t1x9gknd 1634 16 eE ee FW cord-010119-t1x9gknd 1634 17 " " '' cord-010119-t1x9gknd 1634 18 pools pool NNS cord-010119-t1x9gknd 1634 19 of of IN cord-010119-t1x9gknd 1634 20 which which WDT cord-010119-t1x9gknd 1634 21 4 4 CD cord-010119-t1x9gknd 1634 22 were be VBD cord-010119-t1x9gknd 1634 23 demonstrated demonstrate VBN cord-010119-t1x9gknd 1634 24 ( ( -LRB- cord-010119-t1x9gknd 1634 25 in in IN cord-010119-t1x9gknd 1634 26 subsequent subsequent JJ cord-010119-t1x9gknd 1634 27 profiling profiling NN cord-010119-t1x9gknd 1634 28 ) ) -RRB- cord-010119-t1x9gknd 1634 29 to to TO cord-010119-t1x9gknd 1634 30 contain contain VB cord-010119-t1x9gknd 1634 31 an an DT cord-010119-t1x9gknd 1634 32 e e NN cord-010119-t1x9gknd 1634 33 - - NN cord-010119-t1x9gknd 1634 34 sample sample NN cord-010119-t1x9gknd 1634 35 . . . cord-010119-t1x9gknd 1635 1 We -PRON- PRP cord-010119-t1x9gknd 1635 2 also also RB cord-010119-t1x9gknd 1635 3 identified identify VBD cord-010119-t1x9gknd 1635 4 pools pool NNS cord-010119-t1x9gknd 1635 5 " " `` cord-010119-t1x9gknd 1635 6 het het NN cord-010119-t1x9gknd 1635 7 " " '' cord-010119-t1x9gknd 1635 8 for for IN cord-010119-t1x9gknd 1635 9 alleles allele NNS cord-010119-t1x9gknd 1635 10 indicating indicate VBG cord-010119-t1x9gknd 1635 11 the the DT cord-010119-t1x9gknd 1635 12 possible possible JJ cord-010119-t1x9gknd 1635 13 presence presence NN cord-010119-t1x9gknd 1635 14 of of IN cord-010119-t1x9gknd 1635 15 a a DT cord-010119-t1x9gknd 1635 16 rare rare JJ cord-010119-t1x9gknd 1635 17 donor donor NN cord-010119-t1x9gknd 1635 18 , , , cord-010119-t1x9gknd 1635 19 for for IN cord-010119-t1x9gknd 1635 20 example example NN cord-010119-t1x9gknd 1635 21 Yta|b Yta|b NNP cord-010119-t1x9gknd 1635 22 ( ( -LRB- cord-010119-t1x9gknd 1635 23 8 8 CD cord-010119-t1x9gknd 1635 24 pools pool NNS cord-010119-t1x9gknd 1635 25 ) ) -RRB- cord-010119-t1x9gknd 1635 26 , , . cord-010119-t1x9gknd 1636 1 Co Co NNP cord-010119-t1x9gknd 1636 2 a|b a|b NNP cord-010119-t1x9gknd 1636 3 ( ( -LRB- cord-010119-t1x9gknd 1636 4 8) 8) NN cord-010119-t1x9gknd 1636 5 and and CC cord-010119-t1x9gknd 1636 6 others other NNS cord-010119-t1x9gknd 1636 7 . . . cord-010119-t1x9gknd 1637 1 Conclusion conclusion NN cord-010119-t1x9gknd 1637 2 : : : cord-010119-t1x9gknd 1637 3 MolecularSieving MolecularSieving NNP cord-010119-t1x9gknd 1637 4 of of IN cord-010119-t1x9gknd 1637 5 a a DT cord-010119-t1x9gknd 1637 6 single single JJ cord-010119-t1x9gknd 1637 7 96-well 96-well CD cord-010119-t1x9gknd 1637 8 plate plate NN cord-010119-t1x9gknd 1637 9 identified identify VBD cord-010119-t1x9gknd 1637 10 many many JJ cord-010119-t1x9gknd 1637 11 desirable desirable JJ cord-010119-t1x9gknd 1637 12 " " `` cord-010119-t1x9gknd 1637 13 antigen antigen NN cord-010119-t1x9gknd 1637 14 - - HYPH cord-010119-t1x9gknd 1637 15 negative negative JJ cord-010119-t1x9gknd 1637 16 " " `` cord-010119-t1x9gknd 1637 17 phenotypes phenotype NNS cord-010119-t1x9gknd 1637 18 and and CC cord-010119-t1x9gknd 1637 19 permitted permit VBN cord-010119-t1x9gknd 1637 20 selection selection NN cord-010119-t1x9gknd 1637 21 of of IN cord-010119-t1x9gknd 1637 22 pools pool NNS cord-010119-t1x9gknd 1637 23 for for IN cord-010119-t1x9gknd 1637 24 combinations combination NNS cord-010119-t1x9gknd 1637 25 of of IN cord-010119-t1x9gknd 1637 26 " " `` cord-010119-t1x9gknd 1637 27 Ag Ag NNP cord-010119-t1x9gknd 1637 28 - - HYPH cord-010119-t1x9gknd 1637 29 neg neg JJ cord-010119-t1x9gknd 1637 30 " " '' cord-010119-t1x9gknd 1637 31 patterns pattern NNS cord-010119-t1x9gknd 1637 32 including include VBG cord-010119-t1x9gknd 1637 33 " " `` cord-010119-t1x9gknd 1637 34 partial partial JJ cord-010119-t1x9gknd 1637 35 : : : cord-010119-t1x9gknd 1637 36 " " `` cord-010119-t1x9gknd 1637 37 RH RH NNP cord-010119-t1x9gknd 1637 38 phenotypes phenotype NNS cord-010119-t1x9gknd 1637 39 and and CC cord-010119-t1x9gknd 1637 40 combinations combination NNS cord-010119-t1x9gknd 1637 41 of of IN cord-010119-t1x9gknd 1637 42 C2 C2 NNP cord-010119-t1x9gknd 1637 43 , , , cord-010119-t1x9gknd 1637 44 E2 E2 NNP cord-010119-t1x9gknd 1637 45 and and CC cord-010119-t1x9gknd 1637 46 Jsa2 Jsa2 NNP cord-010119-t1x9gknd 1637 47 . . . cord-010119-t1x9gknd 1638 1 These these DT cord-010119-t1x9gknd 1638 2 samples sample NNS cord-010119-t1x9gknd 1638 3 are be VBP cord-010119-t1x9gknd 1638 4 thus thus RB cord-010119-t1x9gknd 1638 5 confirmed confirm VBN cord-010119-t1x9gknd 1638 6 " " `` cord-010119-t1x9gknd 1638 7 ag ag NNP cord-010119-t1x9gknd 1638 8 Neg Neg NNP cord-010119-t1x9gknd 1638 9 " " '' cord-010119-t1x9gknd 1638 10 and and CC cord-010119-t1x9gknd 1638 11 available available JJ cord-010119-t1x9gknd 1638 12 for for IN cord-010119-t1x9gknd 1638 13 assignment assignment NN cord-010119-t1x9gknd 1638 14 . . . cord-010119-t1x9gknd 1639 1 Sieving Sieving NNP cord-010119-t1x9gknd 1639 2 also also RB cord-010119-t1x9gknd 1639 3 facilitated facilitate VBD cord-010119-t1x9gknd 1639 4 the the DT cord-010119-t1x9gknd 1639 5 enrichment enrichment NN cord-010119-t1x9gknd 1639 6 of of IN cord-010119-t1x9gknd 1639 7 subsequent subsequent JJ cord-010119-t1x9gknd 1639 8 refinement refinement NN cord-010119-t1x9gknd 1639 9 of of IN cord-010119-t1x9gknd 1639 10 molecular molecular JJ cord-010119-t1x9gknd 1639 11 attribute attribute NN cord-010119-t1x9gknd 1639 12 profiles profile NNS cord-010119-t1x9gknd 1639 13 in in IN cord-010119-t1x9gknd 1639 14 accordance accordance NN cord-010119-t1x9gknd 1639 15 with with IN cord-010119-t1x9gknd 1639 16 pending pende VBG cord-010119-t1x9gknd 1639 17 or or CC cord-010119-t1x9gknd 1639 18 anticipated anticipate VBN cord-010119-t1x9gknd 1639 19 demand demand NN cord-010119-t1x9gknd 1639 20 . . . cord-010119-t1x9gknd 1640 1 " " '' cord-010119-t1x9gknd 1641 1 antigen antigen NN cord-010119-t1x9gknd 1641 2 - - HYPH cord-010119-t1x9gknd 1641 3 neg neg JJ cord-010119-t1x9gknd 1641 4 " " '' cord-010119-t1x9gknd 1641 5 pattern pattern NN cord-010119-t1x9gknd 1642 1 partial_c partial_c NNP cord-010119-t1x9gknd 1642 2 _SP cord-010119-t1x9gknd 1642 3 partial partial JJ cord-010119-t1x9gknd 1642 4 _ _ NN cord-010119-t1x9gknd 1642 5 c c NN cord-010119-t1x9gknd 1642 6 , , , cord-010119-t1x9gknd 1642 7 _ _ NN cord-010119-t1x9gknd 1642 8 e e NN cord-010119-t1x9gknd 1642 9 _SP cord-010119-t1x9gknd 1642 10 samples sample NNS cord-010119-t1x9gknd 1642 11 available available JJ cord-010119-t1x9gknd 1642 12 _SP cord-010119-t1x9gknd 1642 13 after after IN cord-010119-t1x9gknd 1642 14 sieving sieve VBG cord-010119-t1x9gknd 1642 15 _SP cord-010119-t1x9gknd 1642 16 124 124 CD cord-010119-t1x9gknd 1642 17 _SP cord-010119-t1x9gknd 1643 1 132 132 CD cord-010119-t1x9gknd 1643 2 _SP cord-010119-t1x9gknd 1644 1 100 100 CD cord-010119-t1x9gknd 1644 2 _SP cord-010119-t1x9gknd 1644 3 100 100 CD cord-010119-t1x9gknd 1644 4 _SP cord-010119-t1x9gknd 1644 5 360 360 CD cord-010119-t1x9gknd 1644 6 _SP cord-010119-t1x9gknd 1645 1 208 208 CD cord-010119-t1x9gknd 1645 2 _SP cord-010119-t1x9gknd 1645 3 192 192 CD cord-010119-t1x9gknd 1645 4 _SP cord-010119-t1x9gknd 1645 5 40 40 CD cord-010119-t1x9gknd 1645 6 _SP cord-010119-t1x9gknd 1646 1 28 28 CD cord-010119-t1x9gknd 1646 2 _SP cord-010119-t1x9gknd 1646 3 92 92 CD cord-010119-t1x9gknd 1646 4 _SP cord-010119-t1x9gknd 1647 1 52 52 CD cord-010119-t1x9gknd 1647 2 Background Background NNP cord-010119-t1x9gknd 1647 3 / / SYM cord-010119-t1x9gknd 1647 4 Case Case NNP cord-010119-t1x9gknd 1647 5 Studies Studies NNPS cord-010119-t1x9gknd 1647 6 : : : cord-010119-t1x9gknd 1648 1 Sequence sequence NN cord-010119-t1x9gknd 1648 2 information information NN cord-010119-t1x9gknd 1648 3 generated generate VBN cord-010119-t1x9gknd 1648 4 from from IN cord-010119-t1x9gknd 1648 5 next next JJ cord-010119-t1x9gknd 1648 6 generation generation NN cord-010119-t1x9gknd 1648 7 sequencing sequencing NN cord-010119-t1x9gknd 1648 8 ( ( -LRB- cord-010119-t1x9gknd 1648 9 NGS NGS NNP cord-010119-t1x9gknd 1648 10 ) ) -RRB- cord-010119-t1x9gknd 1648 11 is be VBZ cord-010119-t1x9gknd 1648 12 often often RB cord-010119-t1x9gknd 1648 13 computationally computationally RB cord-010119-t1x9gknd 1648 14 phased phase VBN cord-010119-t1x9gknd 1648 15 using use VBG cord-010119-t1x9gknd 1648 16 haplotype haplotype NN cord-010119-t1x9gknd 1648 17 - - HYPH cord-010119-t1x9gknd 1648 18 phasing phase VBG cord-010119-t1x9gknd 1648 19 algorithms algorithm NNS cord-010119-t1x9gknd 1648 20 . . . cord-010119-t1x9gknd 1649 1 Utilizing utilize VBG cord-010119-t1x9gknd 1649 2 experimentally experimentally RB cord-010119-t1x9gknd 1649 3 derived derive VBN cord-010119-t1x9gknd 1649 4 haplotype haplotype NN cord-010119-t1x9gknd 1649 5 information information NN cord-010119-t1x9gknd 1649 6 improves improve VBZ cord-010119-t1x9gknd 1649 7 this this DT cord-010119-t1x9gknd 1649 8 prediction prediction NN cord-010119-t1x9gknd 1649 9 , , , cord-010119-t1x9gknd 1649 10 as as RB cord-010119-t1x9gknd 1649 11 routinely routinely RB cord-010119-t1x9gknd 1649 12 used use VBN cord-010119-t1x9gknd 1649 13 in in IN cord-010119-t1x9gknd 1649 14 HLA HLA NNP cord-010119-t1x9gknd 1649 15 typing typing NN cord-010119-t1x9gknd 1649 16 . . . cord-010119-t1x9gknd 1650 1 Among among IN cord-010119-t1x9gknd 1650 2 the the DT cord-010119-t1x9gknd 1650 3 36 36 CD cord-010119-t1x9gknd 1650 4 blood blood NN cord-010119-t1x9gknd 1650 5 group group NN cord-010119-t1x9gknd 1650 6 systems system NNS cord-010119-t1x9gknd 1650 7 , , , cord-010119-t1x9gknd 1650 8 however however RB cord-010119-t1x9gknd 1650 9 , , , cord-010119-t1x9gknd 1650 10 experimentally experimentally RB cord-010119-t1x9gknd 1650 11 derived derive VBN cord-010119-t1x9gknd 1650 12 haplotypes haplotype NNS cord-010119-t1x9gknd 1650 13 are be VBP cord-010119-t1x9gknd 1650 14 known know VBN cord-010119-t1x9gknd 1650 15 for for IN cord-010119-t1x9gknd 1650 16 short short JJ cord-010119-t1x9gknd 1650 17 genes gene NNS cord-010119-t1x9gknd 1650 18 only only RB cord-010119-t1x9gknd 1650 19 , , , cord-010119-t1x9gknd 1650 20 such such JJ cord-010119-t1x9gknd 1650 21 as as IN cord-010119-t1x9gknd 1650 22 ICAM4 ICAM4 NNP cord-010119-t1x9gknd 1651 1 ( ( -LRB- cord-010119-t1x9gknd 1651 2 Landsteiner Landsteiner NNP cord-010119-t1x9gknd 1651 3 - - HYPH cord-010119-t1x9gknd 1651 4 Wiener Wiener NNP cord-010119-t1x9gknd 1651 5 ) ) -RRB- cord-010119-t1x9gknd 1651 6 and and CC cord-010119-t1x9gknd 1652 1 ACKR1 ACKR1 NNP cord-010119-t1x9gknd 1653 1 ( ( -LRB- cord-010119-t1x9gknd 1653 2 Duffy Duffy NNP cord-010119-t1x9gknd 1653 3 ) ) -RRB- cord-010119-t1x9gknd 1653 4 . . . cord-010119-t1x9gknd 1654 1 For for IN cord-010119-t1x9gknd 1654 2 longer long JJR cord-010119-t1x9gknd 1654 3 genes gene NNS cord-010119-t1x9gknd 1654 4 , , , cord-010119-t1x9gknd 1654 5 such such JJ cord-010119-t1x9gknd 1654 6 as as IN cord-010119-t1x9gknd 1654 7 ABO ABO NNP cord-010119-t1x9gknd 1654 8 of of IN cord-010119-t1x9gknd 1654 9 > > $ cord-010119-t1x9gknd 1654 10 20 20 CD cord-010119-t1x9gknd 1654 11 kb kb NNP cord-010119-t1x9gknd 1654 12 , , , cord-010119-t1x9gknd 1654 13 most most JJS cord-010119-t1x9gknd 1654 14 haplotypes haplotype NNS cord-010119-t1x9gknd 1654 15 are be VBP cord-010119-t1x9gknd 1654 16 only only RB cord-010119-t1x9gknd 1654 17 statistically statistically RB cord-010119-t1x9gknd 1654 18 derived derive VBN cord-010119-t1x9gknd 1654 19 . . . cord-010119-t1x9gknd 1655 1 We -PRON- PRP cord-010119-t1x9gknd 1655 2 recently recently RB cord-010119-t1x9gknd 1655 3 established establish VBD cord-010119-t1x9gknd 1655 4 a a DT cord-010119-t1x9gknd 1655 5 large large JJ cord-010119-t1x9gknd 1655 6 dataset dataset NN cord-010119-t1x9gknd 1655 7 of of IN cord-010119-t1x9gknd 1655 8 long long JJ cord-010119-t1x9gknd 1655 9 ERMAP ERMAP NNS cord-010119-t1x9gknd 1655 10 haplotypes haplotype NNS cord-010119-t1x9gknd 1655 11 , , , cord-010119-t1x9gknd 1655 12 which which WDT cord-010119-t1x9gknd 1655 13 code code NN cord-010119-t1x9gknd 1655 14 for for IN cord-010119-t1x9gknd 1655 15 the the DT cord-010119-t1x9gknd 1655 16 Scianna Scianna NNP cord-010119-t1x9gknd 1655 17 blood blood NN cord-010119-t1x9gknd 1655 18 group group NN cord-010119-t1x9gknd 1655 19 system system NN cord-010119-t1x9gknd 1655 20 . . . cord-010119-t1x9gknd 1656 1 Study Study NNP cord-010119-t1x9gknd 1656 2 Design Design NNP cord-010119-t1x9gknd 1656 3 / / SYM cord-010119-t1x9gknd 1656 4 Methods method NNS cord-010119-t1x9gknd 1656 5 : : : cord-010119-t1x9gknd 1657 1 The the DT cord-010119-t1x9gknd 1657 2 nucleotide nucleotide JJ cord-010119-t1x9gknd 1657 3 sequence sequence NN cord-010119-t1x9gknd 1657 4 of of IN cord-010119-t1x9gknd 1657 5 > > $ cord-010119-t1x9gknd 1657 6 21 21 CD cord-010119-t1x9gknd 1657 7 kb kb NNP cord-010119-t1x9gknd 1657 8 each each DT cord-010119-t1x9gknd 1657 9 was be VBD cord-010119-t1x9gknd 1657 10 used use VBN cord-010119-t1x9gknd 1657 11 for for IN cord-010119-t1x9gknd 1657 12 all all DT cord-010119-t1x9gknd 1657 13 physically physically RB cord-010119-t1x9gknd 1657 14 confirmed confirm VBN cord-010119-t1x9gknd 1657 15 48 48 CD cord-010119-t1x9gknd 1657 16 ERMAP ERMAP NNS cord-010119-t1x9gknd 1657 17 alleles allele NNS cord-010119-t1x9gknd 1657 18 that that WDT cord-010119-t1x9gknd 1657 19 we -PRON- PRP cord-010119-t1x9gknd 1657 20 previously previously RB cord-010119-t1x9gknd 1657 21 published publish VBD cord-010119-t1x9gknd 1657 22 . . . cord-010119-t1x9gknd 1658 1 Full full JJ cord-010119-t1x9gknd 1658 2 - - HYPH cord-010119-t1x9gknd 1658 3 length length NN cord-010119-t1x9gknd 1658 4 sequences sequence NNS cord-010119-t1x9gknd 1658 5 were be VBD cord-010119-t1x9gknd 1658 6 aligned align VBN cord-010119-t1x9gknd 1658 7 and and CC cord-010119-t1x9gknd 1658 8 variant variant JJ cord-010119-t1x9gknd 1658 9 sites site NNS cord-010119-t1x9gknd 1658 10 were be VBD cord-010119-t1x9gknd 1658 11 extracted extract VBN cord-010119-t1x9gknd 1658 12 manually manually RB cord-010119-t1x9gknd 1658 13 . . . cord-010119-t1x9gknd 1659 1 The the DT cord-010119-t1x9gknd 1659 2 Bayesian bayesian JJ cord-010119-t1x9gknd 1659 3 coalescent coalescent NN cord-010119-t1x9gknd 1659 4 algorithm algorithm NN cord-010119-t1x9gknd 1659 5 implemented implement VBN cord-010119-t1x9gknd 1659 6 in in IN cord-010119-t1x9gknd 1659 7 BEAST BEAST NNP cord-010119-t1x9gknd 1659 8 v1.8.3 v1.8.3 NNP cord-010119-t1x9gknd 1659 9 was be VBD cord-010119-t1x9gknd 1659 10 used use VBN cord-010119-t1x9gknd 1659 11 to to TO cord-010119-t1x9gknd 1659 12 estimate estimate VB cord-010119-t1x9gknd 1659 13 a a DT cord-010119-t1x9gknd 1659 14 coalescent coalescent JJ cord-010119-t1x9gknd 1659 15 phylogeny phylogeny NN cord-010119-t1x9gknd 1659 16 for for IN cord-010119-t1x9gknd 1659 17 these these DT cord-010119-t1x9gknd 1659 18 variants variant NNS cord-010119-t1x9gknd 1659 19 and and CC cord-010119-t1x9gknd 1659 20 the the DT cord-010119-t1x9gknd 1659 21 allelic allelic JJ cord-010119-t1x9gknd 1659 22 ancestral ancestral JJ cord-010119-t1x9gknd 1659 23 states state NNS cord-010119-t1x9gknd 1659 24 at at IN cord-010119-t1x9gknd 1659 25 the the DT cord-010119-t1x9gknd 1659 26 internal internal JJ cord-010119-t1x9gknd 1659 27 nodes node NNS cord-010119-t1x9gknd 1659 28 of of IN cord-010119-t1x9gknd 1659 29 the the DT cord-010119-t1x9gknd 1659 30 phylogeny phylogeny NN cord-010119-t1x9gknd 1659 31 . . . cord-010119-t1x9gknd 1660 1 Results result NNS cord-010119-t1x9gknd 1660 2 / / SYM cord-010119-t1x9gknd 1660 3 Findings finding NNS cord-010119-t1x9gknd 1661 1 : : : cord-010119-t1x9gknd 1661 2 We -PRON- PRP cord-010119-t1x9gknd 1661 3 found find VBD cord-010119-t1x9gknd 1661 4 at at IN cord-010119-t1x9gknd 1661 5 least least JJS cord-010119-t1x9gknd 1661 6 4 4 CD cord-010119-t1x9gknd 1661 7 clades clade NNS cord-010119-t1x9gknd 1661 8 representing represent VBG cord-010119-t1x9gknd 1661 9 clusters cluster NNS cord-010119-t1x9gknd 1661 10 of of IN cord-010119-t1x9gknd 1661 11 5 5 CD cord-010119-t1x9gknd 1661 12 to to TO cord-010119-t1x9gknd 1661 13 11 11 CD cord-010119-t1x9gknd 1661 14 alleles allele NNS cord-010119-t1x9gknd 1661 15 . . . cord-010119-t1x9gknd 1662 1 For for IN cord-010119-t1x9gknd 1662 2 each each DT cord-010119-t1x9gknd 1662 3 clade clade NN cord-010119-t1x9gknd 1662 4 , , , cord-010119-t1x9gknd 1662 5 one one CD cord-010119-t1x9gknd 1662 6 observed observe VBN cord-010119-t1x9gknd 1662 7 allele allele NN cord-010119-t1x9gknd 1662 8 was be VBD cord-010119-t1x9gknd 1662 9 identified identify VBN cord-010119-t1x9gknd 1662 10 as as IN cord-010119-t1x9gknd 1662 11 the the DT cord-010119-t1x9gknd 1662 12 ancestral ancestral JJ cord-010119-t1x9gknd 1662 13 allele allele NN cord-010119-t1x9gknd 1662 14 for for IN cord-010119-t1x9gknd 1662 15 its -PRON- PRP$ cord-010119-t1x9gknd 1662 16 cluster cluster NN cord-010119-t1x9gknd 1662 17 of of IN cord-010119-t1x9gknd 1662 18 alleles allele NNS cord-010119-t1x9gknd 1662 19 . . . cord-010119-t1x9gknd 1663 1 Using use VBG cord-010119-t1x9gknd 1663 2 the the DT cord-010119-t1x9gknd 1663 3 4 4 CD cord-010119-t1x9gknd 1663 4 alleles allele NNS cord-010119-t1x9gknd 1663 5 , , , cord-010119-t1x9gknd 1663 6 we -PRON- PRP cord-010119-t1x9gknd 1663 7 were be VBD cord-010119-t1x9gknd 1663 8 able able JJ cord-010119-t1x9gknd 1663 9 to to TO cord-010119-t1x9gknd 1663 10 predict predict VB cord-010119-t1x9gknd 1663 11 alleles allele NNS cord-010119-t1x9gknd 1663 12 with with IN cord-010119-t1x9gknd 1663 13 high high JJ cord-010119-t1x9gknd 1663 14 posterior posterior JJ cord-010119-t1x9gknd 1663 15 probability probability NN cord-010119-t1x9gknd 1663 16 , , , cord-010119-t1x9gknd 1663 17 which which WDT cord-010119-t1x9gknd 1663 18 were be VBD cord-010119-t1x9gknd 1663 19 ancestral ancestral JJ cord-010119-t1x9gknd 1663 20 to to IN cord-010119-t1x9gknd 1663 21 the the DT cord-010119-t1x9gknd 1663 22 observed observed JJ cord-010119-t1x9gknd 1663 23 alleles allele NNS cord-010119-t1x9gknd 1663 24 and and CC cord-010119-t1x9gknd 1663 25 , , , cord-010119-t1x9gknd 1663 26 while while IN cord-010119-t1x9gknd 1663 27 not not RB cord-010119-t1x9gknd 1663 28 yet yet RB cord-010119-t1x9gknd 1663 29 observed observe VBN cord-010119-t1x9gknd 1663 30 , , , cord-010119-t1x9gknd 1663 31 may may MD cord-010119-t1x9gknd 1663 32 be be VB cord-010119-t1x9gknd 1663 33 extant extant JJ cord-010119-t1x9gknd 1663 34 . . . cord-010119-t1x9gknd 1664 1 Conclusion conclusion NN cord-010119-t1x9gknd 1664 2 : : : cord-010119-t1x9gknd 1665 1 We -PRON- PRP cord-010119-t1x9gknd 1665 2 explored explore VBD cord-010119-t1x9gknd 1665 3 the the DT cord-010119-t1x9gknd 1665 4 phylogenetic phylogenetic JJ cord-010119-t1x9gknd 1665 5 structure structure NN cord-010119-t1x9gknd 1665 6 and and CC cord-010119-t1x9gknd 1665 7 evolutionary evolutionary JJ cord-010119-t1x9gknd 1665 8 events event NNS cord-010119-t1x9gknd 1665 9 underlying underlie VBG cord-010119-t1x9gknd 1665 10 the the DT cord-010119-t1x9gknd 1665 11 origin origin NN cord-010119-t1x9gknd 1665 12 of of IN cord-010119-t1x9gknd 1665 13 different different JJ cord-010119-t1x9gknd 1665 14 ERMAP ERMAP NNS cord-010119-t1x9gknd 1665 15 alleles allele NNS cord-010119-t1x9gknd 1665 16 and and CC cord-010119-t1x9gknd 1665 17 predict predict VB cord-010119-t1x9gknd 1665 18 ancestral ancestral JJ cord-010119-t1x9gknd 1665 19 alleles allele NNS cord-010119-t1x9gknd 1665 20 . . . cord-010119-t1x9gknd 1666 1 In in IN cord-010119-t1x9gknd 1666 2 the the DT cord-010119-t1x9gknd 1666 3 present present JJ cord-010119-t1x9gknd 1666 4 study study NN cord-010119-t1x9gknd 1666 5 , , , cord-010119-t1x9gknd 1666 6 we -PRON- PRP cord-010119-t1x9gknd 1666 7 show show VBP cord-010119-t1x9gknd 1666 8 means mean VBZ cord-010119-t1x9gknd 1666 9 to to TO cord-010119-t1x9gknd 1666 10 predict predict VB cord-010119-t1x9gknd 1666 11 alleles allele NNS cord-010119-t1x9gknd 1666 12 and and CC cord-010119-t1x9gknd 1666 13 to to TO cord-010119-t1x9gknd 1666 14 calculate calculate VB cord-010119-t1x9gknd 1666 15 the the DT cord-010119-t1x9gknd 1666 16 distinct distinct JJ cord-010119-t1x9gknd 1666 17 probabilities probability NNS cord-010119-t1x9gknd 1666 18 of of IN cord-010119-t1x9gknd 1666 19 correctness correctness NN cord-010119-t1x9gknd 1666 20 for for IN cord-010119-t1x9gknd 1666 21 such such JJ cord-010119-t1x9gknd 1666 22 predicted predict VBN cord-010119-t1x9gknd 1666 23 alleles allele NNS cord-010119-t1x9gknd 1666 24 . . . cord-010119-t1x9gknd 1667 1 The the DT cord-010119-t1x9gknd 1667 2 probabilities probability NNS cord-010119-t1x9gknd 1667 3 can can MD cord-010119-t1x9gknd 1667 4 be be VB cord-010119-t1x9gknd 1667 5 instrumental instrumental JJ cord-010119-t1x9gknd 1667 6 in in IN cord-010119-t1x9gknd 1667 7 defining define VBG cord-010119-t1x9gknd 1667 8 a a DT cord-010119-t1x9gknd 1667 9 cut cut VB cord-010119-t1x9gknd 1667 10 - - HYPH cord-010119-t1x9gknd 1667 11 off off RP cord-010119-t1x9gknd 1667 12 value value NN cord-010119-t1x9gknd 1667 13 to to TO cord-010119-t1x9gknd 1667 14 determine determine VB cord-010119-t1x9gknd 1667 15 which which WDT cord-010119-t1x9gknd 1667 16 computationally computationally RB cord-010119-t1x9gknd 1667 17 predicted predict VBN cord-010119-t1x9gknd 1667 18 alleles allele NNS cord-010119-t1x9gknd 1667 19 are be VBP cord-010119-t1x9gknd 1667 20 worth worth JJ cord-010119-t1x9gknd 1667 21 confirming confirm VBG cord-010119-t1x9gknd 1667 22 by by IN cord-010119-t1x9gknd 1667 23 physical physical JJ cord-010119-t1x9gknd 1667 24 evidence evidence NN cord-010119-t1x9gknd 1667 25 . . . cord-010119-t1x9gknd 1668 1 The the DT cord-010119-t1x9gknd 1668 2 alleles allele NNS cord-010119-t1x9gknd 1668 3 identified identify VBN cord-010119-t1x9gknd 1668 4 by by IN cord-010119-t1x9gknd 1668 5 studies study NNS cord-010119-t1x9gknd 1668 6 like like IN cord-010119-t1x9gknd 1668 7 ours our NNS cord-010119-t1x9gknd 1668 8 may may MD cord-010119-t1x9gknd 1668 9 be be VB cord-010119-t1x9gknd 1668 10 utilized utilize VBN cord-010119-t1x9gknd 1668 11 in in IN cord-010119-t1x9gknd 1668 12 designing design VBG cord-010119-t1x9gknd 1668 13 of of IN cord-010119-t1x9gknd 1668 14 microarray microarray NN cord-010119-t1x9gknd 1668 15 technologies technology NNS cord-010119-t1x9gknd 1668 16 , , , cord-010119-t1x9gknd 1668 17 imputing imputing NN cord-010119-t1x9gknd 1668 18 of of IN cord-010119-t1x9gknd 1668 19 genotypes genotype NNS cord-010119-t1x9gknd 1668 20 and and CC cord-010119-t1x9gknd 1668 21 mapping mapping NN cord-010119-t1x9gknd 1668 22 of of IN cord-010119-t1x9gknd 1668 23 NGS NGS NNP cord-010119-t1x9gknd 1668 24 data datum NNS cord-010119-t1x9gknd 1668 25 . . . cord-010119-t1x9gknd 1669 1 The the DT cord-010119-t1x9gknd 1669 2 new new JJ cord-010119-t1x9gknd 1669 3 alleles allele NNS cord-010119-t1x9gknd 1669 4 with with IN cord-010119-t1x9gknd 1669 5 nucleotide nucleotide JJ cord-010119-t1x9gknd 1669 6 insertions insertion NNS cord-010119-t1x9gknd 1669 7 would would MD cord-010119-t1x9gknd 1669 8 be be VB cord-010119-t1x9gknd 1669 9 predicted predict VBN cord-010119-t1x9gknd 1669 10 to to TO cord-010119-t1x9gknd 1669 11 cause cause VB cord-010119-t1x9gknd 1669 12 complete complete JJ cord-010119-t1x9gknd 1669 13 loss loss NN cord-010119-t1x9gknd 1669 14 of of IN cord-010119-t1x9gknd 1669 15 expression expression NN cord-010119-t1x9gknd 1669 16 of of IN cord-010119-t1x9gknd 1669 17 the the DT cord-010119-t1x9gknd 1669 18 corresponding corresponding JJ cord-010119-t1x9gknd 1669 19 antigen antigen NN cord-010119-t1x9gknd 1669 20 from from IN cord-010119-t1x9gknd 1669 21 a a DT cord-010119-t1x9gknd 1669 22 bioinformatics bioinformatics NN cord-010119-t1x9gknd 1669 23 perspective perspective NN cord-010119-t1x9gknd 1669 24 and and CC cord-010119-t1x9gknd 1669 25 to to TO cord-010119-t1x9gknd 1669 26 encode encode VB cord-010119-t1x9gknd 1669 27 Group Group NNP cord-010119-t1x9gknd 1669 28 O. O. NNP cord-010119-t1x9gknd 1669 29 Rather Rather NNP cord-010119-t1x9gknd 1669 30 very very RB cord-010119-t1x9gknd 1669 31 weak weak JJ cord-010119-t1x9gknd 1669 32 expression expression NN cord-010119-t1x9gknd 1669 33 of of IN cord-010119-t1x9gknd 1669 34 the the DT cord-010119-t1x9gknd 1669 35 respective respective JJ cord-010119-t1x9gknd 1669 36 antigen antigen NN cord-010119-t1x9gknd 1669 37 and and CC cord-010119-t1x9gknd 1669 38 lack lack NN cord-010119-t1x9gknd 1669 39 of of IN cord-010119-t1x9gknd 1669 40 the the DT cord-010119-t1x9gknd 1669 41 corresponding correspond VBG cord-010119-t1x9gknd 1669 42 antibody antibody NN cord-010119-t1x9gknd 1669 43 in in IN cord-010119-t1x9gknd 1669 44 the the DT cord-010119-t1x9gknd 1669 45 plasma plasma NN cord-010119-t1x9gknd 1669 46 was be VBD cord-010119-t1x9gknd 1669 47 found find VBN cord-010119-t1x9gknd 1669 48 , , , cord-010119-t1x9gknd 1669 49 confirming confirm VBG cord-010119-t1x9gknd 1669 50 these these DT cord-010119-t1x9gknd 1669 51 represent represent VBP cord-010119-t1x9gknd 1669 52 subgroups subgroup NNS cord-010119-t1x9gknd 1669 53 of of IN cord-010119-t1x9gknd 1669 54 A a NN cord-010119-t1x9gknd 1669 55 and and CC cord-010119-t1x9gknd 1669 56 B b NN cord-010119-t1x9gknd 1669 57 and and CC cord-010119-t1x9gknd 1669 58 suggesting suggest VBG cord-010119-t1x9gknd 1669 59 that that IN cord-010119-t1x9gknd 1669 60 transcriptional transcriptional JJ cord-010119-t1x9gknd 1669 61 slippage slippage NN cord-010119-t1x9gknd 1669 62 , , , cord-010119-t1x9gknd 1669 63 which which WDT cord-010119-t1x9gknd 1669 64 has have VBZ cord-010119-t1x9gknd 1669 65 been be VBN cord-010119-t1x9gknd 1669 66 observed observe VBN cord-010119-t1x9gknd 1669 67 before before RB cord-010119-t1x9gknd 1669 68 , , , cord-010119-t1x9gknd 1669 69 is be VBZ cord-010119-t1x9gknd 1669 70 responsible responsible JJ cord-010119-t1x9gknd 1669 71 for for IN cord-010119-t1x9gknd 1669 72 low low JJ cord-010119-t1x9gknd 1669 73 level level NN cord-010119-t1x9gknd 1669 74 antigen antigen NN cord-010119-t1x9gknd 1669 75 expression expression NN cord-010119-t1x9gknd 1669 76 . . . cord-010119-t1x9gknd 1670 1 ABO ABO NNP cord-010119-t1x9gknd 1670 2 genotyping genotyping NN cord-010119-t1x9gknd 1670 3 is be VBZ cord-010119-t1x9gknd 1670 4 powerful powerful JJ cord-010119-t1x9gknd 1670 5 when when WRB cord-010119-t1x9gknd 1670 6 both both DT cord-010119-t1x9gknd 1670 7 serology serology NN cord-010119-t1x9gknd 1670 8 and and CC cord-010119-t1x9gknd 1670 9 molecular molecular JJ cord-010119-t1x9gknd 1670 10 results result NNS cord-010119-t1x9gknd 1670 11 are be VBP cord-010119-t1x9gknd 1670 12 evaluated evaluate VBN cord-010119-t1x9gknd 1670 13 together together RB cord-010119-t1x9gknd 1670 14 , , , cord-010119-t1x9gknd 1670 15 and and CC cord-010119-t1x9gknd 1670 16 these these DT cord-010119-t1x9gknd 1670 17 studies study NNS cord-010119-t1x9gknd 1670 18 are be VBP cord-010119-t1x9gknd 1670 19 needed need VBN cord-010119-t1x9gknd 1670 20 to to TO cord-010119-t1x9gknd 1670 21 inform inform VB cord-010119-t1x9gknd 1670 22 development development NN cord-010119-t1x9gknd 1670 23 of of IN cord-010119-t1x9gknd 1670 24 bioinformatics bioinformatics NN cord-010119-t1x9gknd 1670 25 tools tool NNS cord-010119-t1x9gknd 1670 26 to to TO cord-010119-t1x9gknd 1670 27 accurately accurately RB cord-010119-t1x9gknd 1670 28 associate associate VB cord-010119-t1x9gknd 1670 29 ABO ABO NNP cord-010119-t1x9gknd 1670 30 genotypes genotype NNS cord-010119-t1x9gknd 1670 31 with with IN cord-010119-t1x9gknd 1670 32 phenotypes phenotype NNS cord-010119-t1x9gknd 1670 33 . . . cord-010119-t1x9gknd 1671 1 Background Background NNP cord-010119-t1x9gknd 1671 2 / / SYM cord-010119-t1x9gknd 1671 3 Case Case NNP cord-010119-t1x9gknd 1671 4 Studies Studies NNPS cord-010119-t1x9gknd 1671 5 : : : cord-010119-t1x9gknd 1672 1 Evolutionarily evolutionarily RB cord-010119-t1x9gknd 1672 2 related relate VBN cord-010119-t1x9gknd 1672 3 ABO ABO NNP cord-010119-t1x9gknd 1672 4 and and CC cord-010119-t1x9gknd 1672 5 GBGT1 GBGT1 NNP cord-010119-t1x9gknd 1672 6 genes gene NNS cord-010119-t1x9gknd 1672 7 encode encode VBP cord-010119-t1x9gknd 1672 8 A a NN cord-010119-t1x9gknd 1672 9 and and CC cord-010119-t1x9gknd 1672 10 B b NN cord-010119-t1x9gknd 1672 11 glycosyltransferases glycosyltransferase NNS cord-010119-t1x9gknd 1672 12 ( ( -LRB- cord-010119-t1x9gknd 1672 13 AT at IN cord-010119-t1x9gknd 1672 14 and and CC cord-010119-t1x9gknd 1672 15 BT BT NNP cord-010119-t1x9gknd 1672 16 ) ) -RRB- cord-010119-t1x9gknd 1672 17 and and CC cord-010119-t1x9gknd 1672 18 Forssman Forssman NNP cord-010119-t1x9gknd 1672 19 glycolipid glycolipid NNP cord-010119-t1x9gknd 1672 20 synthase synthase NN cord-010119-t1x9gknd 1672 21 ( ( -LRB- cord-010119-t1x9gknd 1672 22 FS FS NNP cord-010119-t1x9gknd 1672 23 ) ) -RRB- cord-010119-t1x9gknd 1672 24 , , , cord-010119-t1x9gknd 1672 25 which which WDT cord-010119-t1x9gknd 1672 26 catalyze catalyze VBP cord-010119-t1x9gknd 1672 27 the the DT cord-010119-t1x9gknd 1672 28 biosynthesis biosynthesis NN cord-010119-t1x9gknd 1672 29 of of IN cord-010119-t1x9gknd 1672 30 A a NN cord-010119-t1x9gknd 1672 31 and and CC cord-010119-t1x9gknd 1672 32 B b NN cord-010119-t1x9gknd 1672 33 , , , cord-010119-t1x9gknd 1672 34 and and CC cord-010119-t1x9gknd 1672 35 Forssman Forssman NNP cord-010119-t1x9gknd 1672 36 ( ( -LRB- cord-010119-t1x9gknd 1672 37 FORS1 FORS1 NNP cord-010119-t1x9gknd 1672 38 ) ) -RRB- cord-010119-t1x9gknd 1672 39 oligosaccharide oligosaccharide NN cord-010119-t1x9gknd 1672 40 antigens antigen NNS cord-010119-t1x9gknd 1672 41 responsible responsible JJ cord-010119-t1x9gknd 1672 42 for for IN cord-010119-t1x9gknd 1672 43 the the DT cord-010119-t1x9gknd 1672 44 ABO ABO NNP cord-010119-t1x9gknd 1672 45 and and CC cord-010119-t1x9gknd 1672 46 FORS FORS NNP cord-010119-t1x9gknd 1672 47 blood blood NN cord-010119-t1x9gknd 1672 48 group group NN cord-010119-t1x9gknd 1672 49 systems system NNS cord-010119-t1x9gknd 1672 50 , , , cord-010119-t1x9gknd 1672 51 respectively respectively RB cord-010119-t1x9gknd 1672 52 . . . cord-010119-t1x9gknd 1673 1 Human Human NNP cord-010119-t1x9gknd 1673 2 AT AT NNP cord-010119-t1x9gknd 1673 3 and and CC cord-010119-t1x9gknd 1673 4 BT BT NNP cord-010119-t1x9gknd 1673 5 possess possess VB cord-010119-t1x9gknd 1673 6 LeuGlyGly LeuGlyGly NNP cord-010119-t1x9gknd 1673 7 and and CC cord-010119-t1x9gknd 1673 8 MetGlyAla MetGlyAla NNP cord-010119-t1x9gknd 1673 9 , , , cord-010119-t1x9gknd 1673 10 respectively respectively RB cord-010119-t1x9gknd 1673 11 , , , cord-010119-t1x9gknd 1673 12 at at IN cord-010119-t1x9gknd 1673 13 codons codon NNS cord-010119-t1x9gknd 1673 14 266 266 CD cord-010119-t1x9gknd 1673 15 - - SYM cord-010119-t1x9gknd 1673 16 268 268 CD cord-010119-t1x9gknd 1673 17 , , , cord-010119-t1x9gknd 1673 18 and and CC cord-010119-t1x9gknd 1673 19 these these DT cord-010119-t1x9gknd 1673 20 tripeptides tripeptide NNS cord-010119-t1x9gknd 1673 21 are be VBP cord-010119-t1x9gknd 1673 22 important important JJ cord-010119-t1x9gknd 1673 23 in in IN cord-010119-t1x9gknd 1673 24 determining determine VBG cord-010119-t1x9gknd 1673 25 the the DT cord-010119-t1x9gknd 1673 26 sugar sugar NN cord-010119-t1x9gknd 1673 27 specificity specificity NN cord-010119-t1x9gknd 1673 28 of of IN cord-010119-t1x9gknd 1673 29 enzymes enzyme NNS cord-010119-t1x9gknd 1673 30 , , , cord-010119-t1x9gknd 1673 31 N n CD cord-010119-t1x9gknd 1673 32 - - HYPH cord-010119-t1x9gknd 1673 33 acetyl acetyl NNP cord-010119-t1x9gknd 1673 34 - - HYPH cord-010119-t1x9gknd 1673 35 D d NN cord-010119-t1x9gknd 1673 36 - - HYPH cord-010119-t1x9gknd 1673 37 galactosamine galactosamine NN cord-010119-t1x9gknd 1673 38 ( ( -LRB- cord-010119-t1x9gknd 1673 39 GalNAc GalNAc NNP cord-010119-t1x9gknd 1673 40 ) ) -RRB- cord-010119-t1x9gknd 1673 41 for for IN cord-010119-t1x9gknd 1673 42 AT at NN cord-010119-t1x9gknd 1673 43 and and CC cord-010119-t1x9gknd 1673 44 galactose galactose NN cord-010119-t1x9gknd 1673 45 for for IN cord-010119-t1x9gknd 1673 46 BT BT NNP cord-010119-t1x9gknd 1673 47 . . . cord-010119-t1x9gknd 1674 1 Functional functional JJ cord-010119-t1x9gknd 1674 2 FSs fs NNS cord-010119-t1x9gknd 1674 3 possess possess VBP cord-010119-t1x9gknd 1674 4 Gly Gly NNP cord-010119-t1x9gknd 1674 5 - - HYPH cord-010119-t1x9gknd 1674 6 GlyAla GlyAla NNP cord-010119-t1x9gknd 1674 7 at at IN cord-010119-t1x9gknd 1674 8 the the DT cord-010119-t1x9gknd 1674 9 corresponding correspond VBG cord-010119-t1x9gknd 1674 10 codons codon NNS cord-010119-t1x9gknd 1674 11 , , , cord-010119-t1x9gknd 1674 12 and and CC cord-010119-t1x9gknd 1674 13 exhibit exhibit VB cord-010119-t1x9gknd 1674 14 GalNAc galnac NN cord-010119-t1x9gknd 1674 15 specificity specificity NN cord-010119-t1x9gknd 1674 16 . . . cord-010119-t1x9gknd 1675 1 It -PRON- PRP cord-010119-t1x9gknd 1675 2 has have VBZ cord-010119-t1x9gknd 1675 3 been be VBN cord-010119-t1x9gknd 1675 4 recently recently RB cord-010119-t1x9gknd 1675 5 shown show VBN cord-010119-t1x9gknd 1675 6 that that IN cord-010119-t1x9gknd 1675 7 human human NN cord-010119-t1x9gknd 1675 8 AT at IN cord-010119-t1x9gknd 1675 9 gained gain VBD cord-010119-t1x9gknd 1675 10 weak weak JJ cord-010119-t1x9gknd 1675 11 FS fs NN cord-010119-t1x9gknd 1675 12 activity activity NN cord-010119-t1x9gknd 1675 13 when when WRB cord-010119-t1x9gknd 1675 14 the the DT cord-010119-t1x9gknd 1675 15 Leu Leu NNP cord-010119-t1x9gknd 1675 16 - - HYPH cord-010119-t1x9gknd 1675 17 GlyGly GlyGly NNP cord-010119-t1x9gknd 1675 18 was be VBD cord-010119-t1x9gknd 1675 19 substituted substitute VBN cord-010119-t1x9gknd 1675 20 by by IN cord-010119-t1x9gknd 1675 21 GlyGlyAla GlyGlyAla NNP cord-010119-t1x9gknd 1675 22 , , , cord-010119-t1x9gknd 1675 23 suggesting suggest VBG cord-010119-t1x9gknd 1675 24 that that IN cord-010119-t1x9gknd 1675 25 the the DT cord-010119-t1x9gknd 1675 26 tripeptide tripeptide NN cord-010119-t1x9gknd 1675 27 is be VBZ cord-010119-t1x9gknd 1675 28 involved involve VBN cord-010119-t1x9gknd 1675 29 in in IN cord-010119-t1x9gknd 1675 30 the the DT cord-010119-t1x9gknd 1675 31 recognition recognition NN cord-010119-t1x9gknd 1675 32 / / SYM cord-010119-t1x9gknd 1675 33 binding binding NN cord-010119-t1x9gknd 1675 34 of of IN cord-010119-t1x9gknd 1675 35 acceptor acceptor NN cord-010119-t1x9gknd 1675 36 substrates substrate NNS cord-010119-t1x9gknd 1675 37 , , , cord-010119-t1x9gknd 1675 38 in in IN cord-010119-t1x9gknd 1675 39 addition addition NN cord-010119-t1x9gknd 1675 40 to to IN cord-010119-t1x9gknd 1675 41 donor donor NN cord-010119-t1x9gknd 1675 42 nucleotide nucleotide JJ cord-010119-t1x9gknd 1675 43 - - HYPH cord-010119-t1x9gknd 1675 44 sugar sugar NN cord-010119-t1x9gknd 1675 45 substrates substrate NNS cord-010119-t1x9gknd 1675 46 . . . cord-010119-t1x9gknd 1676 1 Study Study NNP cord-010119-t1x9gknd 1676 2 Design Design NNP cord-010119-t1x9gknd 1676 3 / / SYM cord-010119-t1x9gknd 1676 4 Methods method NNS cord-010119-t1x9gknd 1676 5 : : : cord-010119-t1x9gknd 1676 6 We -PRON- PRP cord-010119-t1x9gknd 1676 7 have have VBP cord-010119-t1x9gknd 1676 8 searched search VBN cord-010119-t1x9gknd 1676 9 for for IN cord-010119-t1x9gknd 1676 10 additional additional JJ cord-010119-t1x9gknd 1676 11 mechanisms mechanism NNS cord-010119-t1x9gknd 1676 12 that that WDT cord-010119-t1x9gknd 1676 13 might may MD cord-010119-t1x9gknd 1676 14 enable enable VB cord-010119-t1x9gknd 1676 15 human human NN cord-010119-t1x9gknd 1676 16 AT at NN cord-010119-t1x9gknd 1676 17 to to TO cord-010119-t1x9gknd 1676 18 express express VB cord-010119-t1x9gknd 1676 19 FORS1 FORS1 NNP cord-010119-t1x9gknd 1676 20 . . . cord-010119-t1x9gknd 1677 1 A a DT cord-010119-t1x9gknd 1677 2 variety variety NN cord-010119-t1x9gknd 1677 3 of of IN cord-010119-t1x9gknd 1677 4 amino amino NN cord-010119-t1x9gknd 1677 5 acid acid NN cord-010119-t1x9gknd 1677 6 substitution substitution NN cord-010119-t1x9gknd 1677 7 constructs construct NNS cord-010119-t1x9gknd 1677 8 of of IN cord-010119-t1x9gknd 1677 9 human human NN cord-010119-t1x9gknd 1677 10 AT AT NNP cord-010119-t1x9gknd 1677 11 were be VBD cord-010119-t1x9gknd 1677 12 prepared prepare VBN cord-010119-t1x9gknd 1677 13 . . . cord-010119-t1x9gknd 1678 1 Additionally additionally RB cord-010119-t1x9gknd 1678 2 , , , cord-010119-t1x9gknd 1678 3 exon exon NN cord-010119-t1x9gknd 1678 4 deletion deletion NN cord-010119-t1x9gknd 1678 5 constructs construct NNS cord-010119-t1x9gknd 1678 6 of of IN cord-010119-t1x9gknd 1678 7 AT AT NNP cord-010119-t1x9gknd 1678 8 mRNA mRNA NNP cord-010119-t1x9gknd 1678 9 transcripts transcript NNS cord-010119-t1x9gknd 1678 10 were be VBD cord-010119-t1x9gknd 1678 11 also also RB cord-010119-t1x9gknd 1678 12 prepared prepare VBN cord-010119-t1x9gknd 1678 13 . . . cord-010119-t1x9gknd 1679 1 DNA DNA NNP cord-010119-t1x9gknd 1679 2 from from IN cord-010119-t1x9gknd 1679 3 those those DT cord-010119-t1x9gknd 1679 4 expression expression NN cord-010119-t1x9gknd 1679 5 constructs construct NNS cord-010119-t1x9gknd 1679 6 was be VBD cord-010119-t1x9gknd 1679 7 transfected transfecte VBN cord-010119-t1x9gknd 1679 8 into into IN cord-010119-t1x9gknd 1679 9 COS1(B3GALNT1 COS1(B3GALNT1 NNP cord-010119-t1x9gknd 1679 10 ) ) -RRB- cord-010119-t1x9gknd 1679 11 cells cell NNS cord-010119-t1x9gknd 1679 12 , , , cord-010119-t1x9gknd 1679 13 and and CC cord-010119-t1x9gknd 1679 14 cell cell NN cord-010119-t1x9gknd 1679 15 - - HYPH cord-010119-t1x9gknd 1679 16 surface surface NN cord-010119-t1x9gknd 1679 17 expression expression NN cord-010119-t1x9gknd 1679 18 of of IN cord-010119-t1x9gknd 1679 19 FORS1 FORS1 NNP cord-010119-t1x9gknd 1679 20 antigen antigen NNP cord-010119-t1x9gknd 1679 21 was be VBD cord-010119-t1x9gknd 1679 22 immunologically immunologically RB cord-010119-t1x9gknd 1679 23 monitored monitor VBN cord-010119-t1x9gknd 1679 24 with with IN cord-010119-t1x9gknd 1679 25 a a DT cord-010119-t1x9gknd 1679 26 monoclonal monoclonal JJ cord-010119-t1x9gknd 1679 27 anti anti JJ cord-010119-t1x9gknd 1679 28 - - JJ cord-010119-t1x9gknd 1679 29 FORS1 fors1 JJ cord-010119-t1x9gknd 1679 30 antibody antibody NN cord-010119-t1x9gknd 1679 31 . . . cord-010119-t1x9gknd 1680 1 Results result NNS cord-010119-t1x9gknd 1680 2 / / SYM cord-010119-t1x9gknd 1680 3 Findings finding NNS cord-010119-t1x9gknd 1681 1 : : : cord-010119-t1x9gknd 1681 2 We -PRON- PRP cord-010119-t1x9gknd 1681 3 found find VBD cord-010119-t1x9gknd 1681 4 that that DT cord-010119-t1x9gknd 1681 5 Met69Thr Met69Thr NNS cord-010119-t1x9gknd 1681 6 / / SYM cord-010119-t1x9gknd 1681 7 Ser ser JJ cord-010119-t1x9gknd 1681 8 substitutions substitution NNS cord-010119-t1x9gknd 1681 9 also also RB cord-010119-t1x9gknd 1681 10 conferred confer VBD cord-010119-t1x9gknd 1681 11 human human NN cord-010119-t1x9gknd 1681 12 AT at IN cord-010119-t1x9gknd 1681 13 with with IN cord-010119-t1x9gknd 1681 14 weak weak JJ cord-010119-t1x9gknd 1681 15 FS fs NN cord-010119-t1x9gknd 1681 16 activity activity NN cord-010119-t1x9gknd 1681 17 . . . cord-010119-t1x9gknd 1682 1 We -PRON- PRP cord-010119-t1x9gknd 1682 2 also also RB cord-010119-t1x9gknd 1682 3 found find VBD cord-010119-t1x9gknd 1682 4 that that IN cord-010119-t1x9gknd 1682 5 the the DT cord-010119-t1x9gknd 1682 6 deletion deletion NN cord-010119-t1x9gknd 1682 7 of of IN cord-010119-t1x9gknd 1682 8 exon exon NN cord-010119-t1x9gknd 1682 9 3 3 CD cord-010119-t1x9gknd 1682 10 or or CC cord-010119-t1x9gknd 1682 11 4 4 CD cord-010119-t1x9gknd 1682 12 of of IN cord-010119-t1x9gknd 1682 13 human human NN cord-010119-t1x9gknd 1682 14 AT at IN cord-010119-t1x9gknd 1682 15 transcripts transcript NNS cord-010119-t1x9gknd 1682 16 bestowed bestow VBD cord-010119-t1x9gknd 1682 17 weak weak JJ cord-010119-t1x9gknd 1682 18 FS fs NN cord-010119-t1x9gknd 1682 19 activity activity NN cord-010119-t1x9gknd 1682 20 . . . cord-010119-t1x9gknd 1683 1 Because because IN cord-010119-t1x9gknd 1683 2 altered alter VBN cord-010119-t1x9gknd 1683 3 RNA rna NN cord-010119-t1x9gknd 1683 4 splicing splicing NN cord-010119-t1x9gknd 1683 5 is be VBZ cord-010119-t1x9gknd 1683 6 frequent frequent JJ cord-010119-t1x9gknd 1683 7 in in IN cord-010119-t1x9gknd 1683 8 cancer cancer NN cord-010119-t1x9gknd 1683 9 , , , cord-010119-t1x9gknd 1683 10 this this DT cord-010119-t1x9gknd 1683 11 mechanism mechanism NN cord-010119-t1x9gknd 1683 12 may may MD cord-010119-t1x9gknd 1683 13 explain explain VB cord-010119-t1x9gknd 1683 14 , , , cord-010119-t1x9gknd 1683 15 at at IN cord-010119-t1x9gknd 1683 16 least least JJS cord-010119-t1x9gknd 1683 17 partially partially RB cord-010119-t1x9gknd 1683 18 , , , cord-010119-t1x9gknd 1683 19 the the DT cord-010119-t1x9gknd 1683 20 appearance appearance NN cord-010119-t1x9gknd 1683 21 of of IN cord-010119-t1x9gknd 1683 22 FORS1 FORS1 NNP cord-010119-t1x9gknd 1683 23 antigen antigen NN cord-010119-t1x9gknd 1683 24 on on IN cord-010119-t1x9gknd 1683 25 certain certain JJ cord-010119-t1x9gknd 1683 26 cancer cancer NN cord-010119-t1x9gknd 1683 27 cells cell NNS cord-010119-t1x9gknd 1683 28 and and CC cord-010119-t1x9gknd 1683 29 tumors tumor NNS cord-010119-t1x9gknd 1683 30 in in IN cord-010119-t1x9gknd 1683 31 Forssman Forssman NNP cord-010119-t1x9gknd 1683 32 antigen antigen NN cord-010119-t1x9gknd 1683 33 - - HYPH cord-010119-t1x9gknd 1683 34 negative negative JJ cord-010119-t1x9gknd 1683 35 human human JJ cord-010119-t1x9gknd 1683 36 species specie NNS cord-010119-t1x9gknd 1683 37 . . . cord-010119-t1x9gknd 1684 1 Furthermore furthermore RB cord-010119-t1x9gknd 1684 2 , , , cord-010119-t1x9gknd 1684 3 the the DT cord-010119-t1x9gknd 1684 4 co co NN cord-010119-t1x9gknd 1684 5 - - NN cord-010119-t1x9gknd 1684 6 introduction introduction NN cord-010119-t1x9gknd 1684 7 of of IN cord-010119-t1x9gknd 1684 8 one one CD cord-010119-t1x9gknd 1684 9 of of IN cord-010119-t1x9gknd 1684 10 those those DT cord-010119-t1x9gknd 1684 11 changes change NNS cord-010119-t1x9gknd 1684 12 together together RB cord-010119-t1x9gknd 1684 13 with with IN cord-010119-t1x9gknd 1684 14 the the DT cord-010119-t1x9gknd 1684 15 GlyGlyAla GlyGlyAla NNP cord-010119-t1x9gknd 1684 16 substitution substitution NN cord-010119-t1x9gknd 1684 17 synergistically synergistically RB cord-010119-t1x9gknd 1684 18 conferred confer VBD cord-010119-t1x9gknd 1684 19 strong strong JJ cord-010119-t1x9gknd 1684 20 FS fs NN cord-010119-t1x9gknd 1684 21 activity activity NN cord-010119-t1x9gknd 1684 22 , , , cord-010119-t1x9gknd 1684 23 in in IN cord-010119-t1x9gknd 1684 24 addition addition NN cord-010119-t1x9gknd 1684 25 to to IN cord-010119-t1x9gknd 1684 26 strong strong JJ cord-010119-t1x9gknd 1684 27 AT AT NNP cord-010119-t1x9gknd 1684 28 and and CC cord-010119-t1x9gknd 1684 29 BT BT NNP cord-010119-t1x9gknd 1684 30 activities activity NNS cord-010119-t1x9gknd 1684 31 . . . cord-010119-t1x9gknd 1685 1 Conclusion conclusion NN cord-010119-t1x9gknd 1685 2 : : : cord-010119-t1x9gknd 1686 1 The the DT cord-010119-t1x9gknd 1686 2 substitution substitution NN cord-010119-t1x9gknd 1686 3 of of IN cord-010119-t1x9gknd 1686 4 the the DT cord-010119-t1x9gknd 1686 5 GlyGlyAla GlyGlyAla NNP cord-010119-t1x9gknd 1686 6 tripeptide tripeptide NN cord-010119-t1x9gknd 1686 7 codon codon NN cord-010119-t1x9gknd 1686 8 in in IN cord-010119-t1x9gknd 1686 9 the the DT cord-010119-t1x9gknd 1686 10 catalytic catalytic JJ cord-010119-t1x9gknd 1686 11 domain domain NN cord-010119-t1x9gknd 1686 12 may may MD cord-010119-t1x9gknd 1686 13 modify modify VB cord-010119-t1x9gknd 1686 14 the the DT cord-010119-t1x9gknd 1686 15 acceptor acceptor NN cord-010119-t1x9gknd 1686 16 specificity specificity NN cord-010119-t1x9gknd 1686 17 of of IN cord-010119-t1x9gknd 1686 18 the the DT cord-010119-t1x9gknd 1686 19 enzyme enzyme NN cord-010119-t1x9gknd 1686 20 . . . cord-010119-t1x9gknd 1687 1 Met69Thr/ Met69Thr/ , cord-010119-t1x9gknd 1687 2 Ser Ser NNP cord-010119-t1x9gknd 1687 3 or or CC cord-010119-t1x9gknd 1687 4 exon exon NN cord-010119-t1x9gknd 1687 5 3/4 3/4 CD cord-010119-t1x9gknd 1687 6 deletion deletion NN cord-010119-t1x9gknd 1687 7 may may MD cord-010119-t1x9gknd 1687 8 alter alter VB cord-010119-t1x9gknd 1687 9 the the DT cord-010119-t1x9gknd 1687 10 intra intra JJ cord-010119-t1x9gknd 1687 11 - - JJ cord-010119-t1x9gknd 1687 12 Glogi Glogi NNP cord-010119-t1x9gknd 1687 13 localization localization NN cord-010119-t1x9gknd 1687 14 of of IN cord-010119-t1x9gknd 1687 15 the the DT cord-010119-t1x9gknd 1687 16 enzyme enzyme NN cord-010119-t1x9gknd 1687 17 . . . cord-010119-t1x9gknd 1688 1 And and CC cord-010119-t1x9gknd 1688 2 those those DT cord-010119-t1x9gknd 1688 3 mechanisms mechanism NNS cord-010119-t1x9gknd 1688 4 function function VBP cord-010119-t1x9gknd 1688 5 in in IN cord-010119-t1x9gknd 1688 6 synergy synergy NN cord-010119-t1x9gknd 1688 7 . . . cord-010119-t1x9gknd 1689 1 The the DT cord-010119-t1x9gknd 1689 2 overlapping overlapping JJ cord-010119-t1x9gknd 1689 3 usage usage NN cord-010119-t1x9gknd 1689 4 of of IN cord-010119-t1x9gknd 1689 5 acceptors acceptor NNS cord-010119-t1x9gknd 1689 6 by by IN cord-010119-t1x9gknd 1689 7 glycosyltransferases glycosyltransferase NNS cord-010119-t1x9gknd 1689 8 encoded encode VBN cord-010119-t1x9gknd 1689 9 by by IN cord-010119-t1x9gknd 1689 10 ABO ABO NNP cord-010119-t1x9gknd 1689 11 and and CC cord-010119-t1x9gknd 1689 12 GBGT1 GBGT1 NNP cord-010119-t1x9gknd 1689 13 genes gene NNS cord-010119-t1x9gknd 1689 14 is be VBZ cord-010119-t1x9gknd 1689 15 reminiscent reminiscent JJ cord-010119-t1x9gknd 1689 16 of of IN cord-010119-t1x9gknd 1689 17 common common JJ cord-010119-t1x9gknd 1689 18 ancestral ancestral JJ cord-010119-t1x9gknd 1689 19 origin origin NN cord-010119-t1x9gknd 1689 20 of of IN cord-010119-t1x9gknd 1689 21 alpha alpha NNP cord-010119-t1x9gknd 1689 22 1,3-Gal(NAc 1,3-gal(nac CD cord-010119-t1x9gknd 1689 23 ) ) -RRB- cord-010119-t1x9gknd 1689 24 transferase transferase NN cord-010119-t1x9gknd 1689 25 genes gene NNS cord-010119-t1x9gknd 1689 26 . . . cord-010119-t1x9gknd 1690 1 The the DT cord-010119-t1x9gknd 1690 2 finding finding NN cord-010119-t1x9gknd 1690 3 that that IN cord-010119-t1x9gknd 1690 4 AT AT NNP cord-010119-t1x9gknd 1690 5 can can MD cord-010119-t1x9gknd 1690 6 synthesize synthesize VB cord-010119-t1x9gknd 1690 7 FORS1 FORS1 NNP cord-010119-t1x9gknd 1690 8 implicates implicate VBZ cord-010119-t1x9gknd 1690 9 that that IN cord-010119-t1x9gknd 1690 10 the the DT cord-010119-t1x9gknd 1690 11 boundary boundary NN cord-010119-t1x9gknd 1690 12 between between IN cord-010119-t1x9gknd 1690 13 ABO ABO NNP cord-010119-t1x9gknd 1690 14 and and CC cord-010119-t1x9gknd 1690 15 FORS FORS NNP cord-010119-t1x9gknd 1690 16 systems system NNS cord-010119-t1x9gknd 1690 17 may may MD cord-010119-t1x9gknd 1690 18 not not RB cord-010119-t1x9gknd 1690 19 be be VB cord-010119-t1x9gknd 1690 20 as as RB cord-010119-t1x9gknd 1690 21 strict strict JJ cord-010119-t1x9gknd 1690 22 as as IN cord-010119-t1x9gknd 1690 23 was be VBD cord-010119-t1x9gknd 1690 24 previously previously RB cord-010119-t1x9gknd 1690 25 delineated delineate VBN cord-010119-t1x9gknd 1690 26 due due IN cord-010119-t1x9gknd 1690 27 to to IN cord-010119-t1x9gknd 1690 28 the the DT cord-010119-t1x9gknd 1690 29 crosstalk crosstalk NN cord-010119-t1x9gknd 1690 30 in in IN cord-010119-t1x9gknd 1690 31 - - HYPH cord-010119-t1x9gknd 1690 32 between between NN cord-010119-t1x9gknd 1690 33 . . . cord-010119-t1x9gknd 1691 1 Rh Rh NNP cord-010119-t1x9gknd 1691 2 typing typing NN cord-010119-t1x9gknd 1691 3 is be VBZ cord-010119-t1x9gknd 1691 4 required require VBN cord-010119-t1x9gknd 1691 5 by by IN cord-010119-t1x9gknd 1691 6 the the DT cord-010119-t1x9gknd 1691 7 FDA FDA NNP cord-010119-t1x9gknd 1691 8 and and CC cord-010119-t1x9gknd 1691 9 FACT FACT NNP cord-010119-t1x9gknd 1691 10 / / SYM cord-010119-t1x9gknd 1691 11 AABB AABB NNP cord-010119-t1x9gknd 1691 12 for for IN cord-010119-t1x9gknd 1691 13 identity identity NN cord-010119-t1x9gknd 1691 14 testing testing NN cord-010119-t1x9gknd 1691 15 . . . cord-010119-t1x9gknd 1692 1 Since since IN cord-010119-t1x9gknd 1692 2 most most JJS cord-010119-t1x9gknd 1692 3 antibodies antibody NNS cord-010119-t1x9gknd 1692 4 in in IN cord-010119-t1x9gknd 1692 5 CB CB NNP cord-010119-t1x9gknd 1692 6 plasma plasma NN cord-010119-t1x9gknd 1692 7 are be VBP cord-010119-t1x9gknd 1692 8 maternal maternal JJ cord-010119-t1x9gknd 1692 9 in in IN cord-010119-t1x9gknd 1692 10 origin origin NN cord-010119-t1x9gknd 1692 11 , , , cord-010119-t1x9gknd 1692 12 the the DT cord-010119-t1x9gknd 1692 13 ABO ABO NNP cord-010119-t1x9gknd 1692 14 / / SYM cord-010119-t1x9gknd 1692 15 Rh Rh NNP cord-010119-t1x9gknd 1692 16 phenotype phenotype NN cord-010119-t1x9gknd 1692 17 relies rely VBZ cord-010119-t1x9gknd 1692 18 only only RB cord-010119-t1x9gknd 1692 19 on on IN cord-010119-t1x9gknd 1692 20 the the DT cord-010119-t1x9gknd 1692 21 red red JJ cord-010119-t1x9gknd 1692 22 cell cell NN cord-010119-t1x9gknd 1692 23 typing typing NN cord-010119-t1x9gknd 1692 24 . . . cord-010119-t1x9gknd 1693 1 A a NN cord-010119-t1x9gknd 1693 2 and and CC cord-010119-t1x9gknd 1693 3 B b NN cord-010119-t1x9gknd 1693 4 antigens antigen NNS cord-010119-t1x9gknd 1693 5 are be VBP cord-010119-t1x9gknd 1693 6 not not RB cord-010119-t1x9gknd 1693 7 fully fully RB cord-010119-t1x9gknd 1693 8 developed develop VBN cord-010119-t1x9gknd 1693 9 at at IN cord-010119-t1x9gknd 1693 10 birth birth NN cord-010119-t1x9gknd 1693 11 , , , cord-010119-t1x9gknd 1693 12 presenting present VBG cord-010119-t1x9gknd 1693 13 about about RB cord-010119-t1x9gknd 1693 14 one one CD cord-010119-t1x9gknd 1693 15 third third NN cord-010119-t1x9gknd 1693 16 of of IN cord-010119-t1x9gknd 1693 17 A a NN cord-010119-t1x9gknd 1693 18 or or CC cord-010119-t1x9gknd 1693 19 B b NN cord-010119-t1x9gknd 1693 20 antigen antigen NN cord-010119-t1x9gknd 1693 21 expression expression NN cord-010119-t1x9gknd 1693 22 levels level NNS cord-010119-t1x9gknd 1693 23 compared compare VBN cord-010119-t1x9gknd 1693 24 to to IN cord-010119-t1x9gknd 1693 25 adult adult NN cord-010119-t1x9gknd 1693 26 cells cell NNS cord-010119-t1x9gknd 1693 27 . . . cord-010119-t1x9gknd 1694 1 This this DT cord-010119-t1x9gknd 1694 2 can can MD cord-010119-t1x9gknd 1694 3 result result VB cord-010119-t1x9gknd 1694 4 in in IN cord-010119-t1x9gknd 1694 5 indeterminate indeterminate JJ cord-010119-t1x9gknd 1694 6 ABO ABO NNP cord-010119-t1x9gknd 1694 7 results result NNS cord-010119-t1x9gknd 1694 8 for for IN cord-010119-t1x9gknd 1694 9 some some DT cord-010119-t1x9gknd 1694 10 CB CB NNP cord-010119-t1x9gknd 1694 11 products product NNS cord-010119-t1x9gknd 1694 12 . . . cord-010119-t1x9gknd 1695 1 We -PRON- PRP cord-010119-t1x9gknd 1695 2 evaluated evaluate VBD cord-010119-t1x9gknd 1695 3 the the DT cord-010119-t1x9gknd 1695 4 use use NN cord-010119-t1x9gknd 1695 5 of of IN cord-010119-t1x9gknd 1695 6 DNA dna NN cord-010119-t1x9gknd 1695 7 - - HYPH cord-010119-t1x9gknd 1695 8 based base VBN cord-010119-t1x9gknd 1695 9 methods method NNS cord-010119-t1x9gknd 1695 10 for for IN cord-010119-t1x9gknd 1695 11 ABO ABO NNP cord-010119-t1x9gknd 1695 12 typing type VBG cord-010119-t1x9gknd 1695 13 to to TO cord-010119-t1x9gknd 1695 14 aid aid VB cord-010119-t1x9gknd 1695 15 the the DT cord-010119-t1x9gknd 1695 16 resolution resolution NN cord-010119-t1x9gknd 1695 17 of of IN cord-010119-t1x9gknd 1695 18 inconclusive inconclusive JJ cord-010119-t1x9gknd 1695 19 ( ( -LRB- cord-010119-t1x9gknd 1695 20 " " `` cord-010119-t1x9gknd 1695 21 indeterminate indeterminate JJ cord-010119-t1x9gknd 1695 22 " " '' cord-010119-t1x9gknd 1695 23 ) ) -RRB- cord-010119-t1x9gknd 1695 24 or or CC cord-010119-t1x9gknd 1695 25 discrepant discrepant JJ cord-010119-t1x9gknd 1695 26 serologic serologic NN cord-010119-t1x9gknd 1695 27 typing typing NN cord-010119-t1x9gknd 1695 28 results result NNS cord-010119-t1x9gknd 1695 29 . . . cord-010119-t1x9gknd 1696 1 Study Study NNP cord-010119-t1x9gknd 1696 2 Design Design NNP cord-010119-t1x9gknd 1696 3 / / SYM cord-010119-t1x9gknd 1696 4 Methods method NNS cord-010119-t1x9gknd 1696 5 : : : cord-010119-t1x9gknd 1697 1 A a DT cord-010119-t1x9gknd 1697 2 total total NN cord-010119-t1x9gknd 1697 3 of of IN cord-010119-t1x9gknd 1697 4 29,308 29,308 CD cord-010119-t1x9gknd 1697 5 CB CB NNP cord-010119-t1x9gknd 1697 6 units unit NNS cord-010119-t1x9gknd 1697 7 ( ( -LRB- cord-010119-t1x9gknd 1697 8 CBU CBU NNP cord-010119-t1x9gknd 1697 9 ) ) -RRB- cord-010119-t1x9gknd 1697 10 were be VBD cord-010119-t1x9gknd 1697 11 typed type VBN cord-010119-t1x9gknd 1697 12 for for IN cord-010119-t1x9gknd 1697 13 ABO ABO NNP cord-010119-t1x9gknd 1697 14 / / SYM cord-010119-t1x9gknd 1697 15 Rh Rh NNP cord-010119-t1x9gknd 1697 16 ( ( -LRB- cord-010119-t1x9gknd 1697 17 Beckman Beckman NNP cord-010119-t1x9gknd 1697 18 Coulter Coulter NNP cord-010119-t1x9gknd 1697 19 PK PK NNP cord-010119-t1x9gknd 1697 20 System System NNP cord-010119-t1x9gknd 1697 21 Blood blood NN cord-010119-t1x9gknd 1697 22 Grouping Grouping NNP cord-010119-t1x9gknd 1697 23 and and CC cord-010119-t1x9gknd 1697 24 Phenotyping Phenotyping NNP cord-010119-t1x9gknd 1697 25 ) ) -RRB- cord-010119-t1x9gknd 1697 26 during during IN cord-010119-t1x9gknd 1697 27 the the DT cord-010119-t1x9gknd 1697 28 period period NN cord-010119-t1x9gknd 1697 29 7/1/2008 7/1/2008 CD cord-010119-t1x9gknd 1697 30 -4/1/2017 -4/1/2017 NNS cord-010119-t1x9gknd 1697 31 . . . cord-010119-t1x9gknd 1698 1 ABO ABO NNP cord-010119-t1x9gknd 1698 2 genotyping genotyping NN cord-010119-t1x9gknd 1698 3 targeting target VBG cord-010119-t1x9gknd 1698 4 specific specific JJ cord-010119-t1x9gknd 1698 5 SNPs snp NNS cord-010119-t1x9gknd 1698 6 for for IN cord-010119-t1x9gknd 1698 7 Groups Groups NNPS cord-010119-t1x9gknd 1698 8 A A NNP cord-010119-t1x9gknd 1698 9 , , , cord-010119-t1x9gknd 1698 10 A2 A2 NNP cord-010119-t1x9gknd 1698 11 , , , cord-010119-t1x9gknd 1698 12 B B NNP cord-010119-t1x9gknd 1698 13 , , , cord-010119-t1x9gknd 1698 14 O1 o1 NN cord-010119-t1x9gknd 1698 15 , , , cord-010119-t1x9gknd 1698 16 and and CC cord-010119-t1x9gknd 1698 17 O2 O2 NNP cord-010119-t1x9gknd 1698 18 and and CC cord-010119-t1x9gknd 1698 19 , , , cord-010119-t1x9gknd 1698 20 if if IN cord-010119-t1x9gknd 1698 21 needed need VBN cord-010119-t1x9gknd 1698 22 , , , cord-010119-t1x9gknd 1698 23 gene gene NN cord-010119-t1x9gknd 1698 24 sequencing sequencing NN cord-010119-t1x9gknd 1698 25 was be VBD cord-010119-t1x9gknd 1698 26 conducted conduct VBN cord-010119-t1x9gknd 1698 27 in in IN cord-010119-t1x9gknd 1698 28 cases case NNS cord-010119-t1x9gknd 1698 29 with with IN cord-010119-t1x9gknd 1698 30 indeterminate indeterminate JJ cord-010119-t1x9gknd 1698 31 results result NNS cord-010119-t1x9gknd 1698 32 , , , cord-010119-t1x9gknd 1698 33 and and CC cord-010119-t1x9gknd 1698 34 in in IN cord-010119-t1x9gknd 1698 35 4 4 CD cord-010119-t1x9gknd 1698 36 CBU CBU NNP cord-010119-t1x9gknd 1698 37 that that WDT cord-010119-t1x9gknd 1698 38 were be VBD cord-010119-t1x9gknd 1698 39 provided provide VBN cord-010119-t1x9gknd 1698 40 for for IN cord-010119-t1x9gknd 1698 41 transplantation transplantation NN cord-010119-t1x9gknd 1698 42 with with IN cord-010119-t1x9gknd 1698 43 ABO ABO NNP cord-010119-t1x9gknd 1698 44 discrepancy discrepancy NN cord-010119-t1x9gknd 1698 45 found find VBN cord-010119-t1x9gknd 1698 46 at at IN cord-010119-t1x9gknd 1698 47 the the DT cord-010119-t1x9gknd 1698 48 transplant transplant NN cord-010119-t1x9gknd 1698 49 center center NN cord-010119-t1x9gknd 1698 50 . . . cord-010119-t1x9gknd 1699 1 Results/ Results/ . cord-010119-t1x9gknd 1700 1 Findings finding NNS cord-010119-t1x9gknd 1700 2 : : : cord-010119-t1x9gknd 1701 1 Sixty sixty CD cord-010119-t1x9gknd 1701 2 - - HYPH cord-010119-t1x9gknd 1701 3 two two CD cord-010119-t1x9gknd 1701 4 ( ( -LRB- cord-010119-t1x9gknd 1701 5 0.21 0.21 CD cord-010119-t1x9gknd 1701 6 % % NN cord-010119-t1x9gknd 1701 7 ) ) -RRB- cord-010119-t1x9gknd 1702 1 CB CB NNP cord-010119-t1x9gknd 1702 2 samples sample NNS cord-010119-t1x9gknd 1702 3 had have VBD cord-010119-t1x9gknd 1702 4 no no DT cord-010119-t1x9gknd 1702 5 reportable reportable JJ cord-010119-t1x9gknd 1702 6 ABO/ ABO/ NNP cord-010119-t1x9gknd 1702 7 Rh Rh NNP cord-010119-t1x9gknd 1702 8 phenotype phenotype NN cord-010119-t1x9gknd 1702 9 on on IN cord-010119-t1x9gknd 1702 10 initial initial JJ cord-010119-t1x9gknd 1702 11 testing testing NN cord-010119-t1x9gknd 1702 12 , , , cord-010119-t1x9gknd 1702 13 and and CC cord-010119-t1x9gknd 1702 14 therefore therefore RB cord-010119-t1x9gknd 1702 15 the the DT cord-010119-t1x9gknd 1702 16 CBU CBU NNP cord-010119-t1x9gknd 1702 17 could could MD cord-010119-t1x9gknd 1702 18 not not RB cord-010119-t1x9gknd 1702 19 be be VB cord-010119-t1x9gknd 1702 20 used use VBN cord-010119-t1x9gknd 1702 21 clinically clinically RB cord-010119-t1x9gknd 1702 22 . . . cord-010119-t1x9gknd 1703 1 Molecular molecular JJ cord-010119-t1x9gknd 1703 2 ABO ABO NNP cord-010119-t1x9gknd 1703 3 / / SYM cord-010119-t1x9gknd 1703 4 Rh Rh NNP cord-010119-t1x9gknd 1703 5 typing typing NN cord-010119-t1x9gknd 1703 6 resolved resolve VBD cord-010119-t1x9gknd 1703 7 all all DT cord-010119-t1x9gknd 1703 8 but but IN cord-010119-t1x9gknd 1703 9 one one CD cord-010119-t1x9gknd 1703 10 . . . cord-010119-t1x9gknd 1704 1 All all DT cord-010119-t1x9gknd 1704 2 cases case NNS cord-010119-t1x9gknd 1704 3 were be VBD cord-010119-t1x9gknd 1704 4 heterozygous heterozygous JJ cord-010119-t1x9gknd 1705 1 ( ( -LRB- cord-010119-t1x9gknd 1705 2 A a NN cord-010119-t1x9gknd 1705 3 / / SYM cord-010119-t1x9gknd 1705 4 O o UH cord-010119-t1x9gknd 1705 5 , , , cord-010119-t1x9gknd 1705 6 B b NN cord-010119-t1x9gknd 1705 7 / / SYM cord-010119-t1x9gknd 1705 8 O o UH cord-010119-t1x9gknd 1705 9 , , , cord-010119-t1x9gknd 1705 10 or or CC cord-010119-t1x9gknd 1705 11 A a NN cord-010119-t1x9gknd 1705 12 / / SYM cord-010119-t1x9gknd 1705 13 B b NN cord-010119-t1x9gknd 1705 14 ) ) -RRB- cord-010119-t1x9gknd 1705 15 ; ; : cord-010119-t1x9gknd 1705 16 in in IN cord-010119-t1x9gknd 1705 17 53 53 CD cord-010119-t1x9gknd 1705 18 % % NN cord-010119-t1x9gknd 1705 19 the the DT cord-010119-t1x9gknd 1705 20 predicted predict VBN cord-010119-t1x9gknd 1705 21 ABO ABO NNP cord-010119-t1x9gknd 1705 22 phenotype phenotype NN cord-010119-t1x9gknd 1705 23 was be VBD cord-010119-t1x9gknd 1705 24 A a DT cord-010119-t1x9gknd 1705 25 Rh Rh NNP cord-010119-t1x9gknd 1705 26 neg neg JJ cord-010119-t1x9gknd 1705 27 ( ( -LRB- cord-010119-t1x9gknd 1705 28 Table Table NNP cord-010119-t1x9gknd 1705 29 1a 1a CD cord-010119-t1x9gknd 1705 30 ) ) -RRB- cord-010119-t1x9gknd 1705 31 . . . cord-010119-t1x9gknd 1706 1 The the DT cord-010119-t1x9gknd 1706 2 predominant predominant JJ cord-010119-t1x9gknd 1706 3 donor donor NN cord-010119-t1x9gknd 1706 4 race race NN cord-010119-t1x9gknd 1706 5 was be VBD cord-010119-t1x9gknd 1706 6 Caucasian caucasian JJ cord-010119-t1x9gknd 1706 7 ( ( -LRB- cord-010119-t1x9gknd 1706 8 65 65 CD cord-010119-t1x9gknd 1706 9 % % NN cord-010119-t1x9gknd 1706 10 ) ) -RRB- cord-010119-t1x9gknd 1706 11 . . . cord-010119-t1x9gknd 1707 1 Four four CD cord-010119-t1x9gknd 1707 2 CBU CBU NNP cord-010119-t1x9gknd 1707 3 with with IN cord-010119-t1x9gknd 1707 4 ABO ABO NNP cord-010119-t1x9gknd 1707 5 discrepancy discrepancy NN cord-010119-t1x9gknd 1707 6 were be VBD cord-010119-t1x9gknd 1707 7 also also RB cord-010119-t1x9gknd 1707 8 evaluated evaluate VBN cord-010119-t1x9gknd 1707 9 by by IN cord-010119-t1x9gknd 1707 10 genotyping genotype VBG cord-010119-t1x9gknd 1707 11 ( ( -LRB- cord-010119-t1x9gknd 1707 12 Table table NN cord-010119-t1x9gknd 1707 13 1b 1b CD cord-010119-t1x9gknd 1707 14 ) ) -RRB- cord-010119-t1x9gknd 1707 15 . . . cord-010119-t1x9gknd 1708 1 In in IN cord-010119-t1x9gknd 1708 2 3 3 CD cord-010119-t1x9gknd 1708 3 of of IN cord-010119-t1x9gknd 1708 4 those those DT cord-010119-t1x9gknd 1708 5 , , , cord-010119-t1x9gknd 1708 6 ABO ABO NNP cord-010119-t1x9gknd 1708 7 typing type VBG cord-010119-t1x9gknd 1708 8 performed perform VBN cord-010119-t1x9gknd 1708 9 at at IN cord-010119-t1x9gknd 1708 10 the the DT cord-010119-t1x9gknd 1708 11 hospital hospital NN cord-010119-t1x9gknd 1708 12 on on IN cord-010119-t1x9gknd 1708 13 the the DT cord-010119-t1x9gknd 1708 14 day day NN cord-010119-t1x9gknd 1708 15 of of IN cord-010119-t1x9gknd 1708 16 transplant transplant NN cord-010119-t1x9gknd 1708 17 differed differ VBD cord-010119-t1x9gknd 1708 18 from from IN cord-010119-t1x9gknd 1708 19 that that DT cord-010119-t1x9gknd 1708 20 reported report VBN cord-010119-t1x9gknd 1708 21 by by IN cord-010119-t1x9gknd 1708 22 the the DT cord-010119-t1x9gknd 1708 23 CB CB NNP cord-010119-t1x9gknd 1708 24 bank bank NN cord-010119-t1x9gknd 1708 25 ; ; : cord-010119-t1x9gknd 1708 26 the the DT cord-010119-t1x9gknd 1708 27 fourth fourth JJ cord-010119-t1x9gknd 1708 28 was be VBD cord-010119-t1x9gknd 1708 29 identified identify VBN cord-010119-t1x9gknd 1708 30 by by IN cord-010119-t1x9gknd 1708 31 posttransplant posttransplant NN cord-010119-t1x9gknd 1708 32 ABO ABO NNP cord-010119-t1x9gknd 1708 33 typing type VBG cord-010119-t1x9gknd 1708 34 of of IN cord-010119-t1x9gknd 1708 35 the the DT cord-010119-t1x9gknd 1708 36 recipient recipient NN cord-010119-t1x9gknd 1708 37 . . . cord-010119-t1x9gknd 1709 1 Molecular molecular JJ cord-010119-t1x9gknd 1709 2 genotyping genotyping NN cord-010119-t1x9gknd 1709 3 resolved resolve VBD cord-010119-t1x9gknd 1709 4 the the DT cord-010119-t1x9gknd 1709 5 discrepancies discrepancy NNS cord-010119-t1x9gknd 1709 6 . . . cord-010119-t1x9gknd 1710 1 CBU CBU NNP cord-010119-t1x9gknd 1710 2 identity identity NN cord-010119-t1x9gknd 1710 3 was be VBD cord-010119-t1x9gknd 1710 4 always always RB cord-010119-t1x9gknd 1710 5 verified verify VBN cord-010119-t1x9gknd 1710 6 by by IN cord-010119-t1x9gknd 1710 7 confirmatory confirmatory JJ cord-010119-t1x9gknd 1710 8 HLA HLA NNP cord-010119-t1x9gknd 1710 9 typing typing NN cord-010119-t1x9gknd 1710 10 . . . cord-010119-t1x9gknd 1711 1 Conclusion conclusion NN cord-010119-t1x9gknd 1711 2 : : : cord-010119-t1x9gknd 1712 1 There there EX cord-010119-t1x9gknd 1712 2 is be VBZ cord-010119-t1x9gknd 1712 3 currently currently RB cord-010119-t1x9gknd 1712 4 no no DT cord-010119-t1x9gknd 1712 5 FDA FDA NNP cord-010119-t1x9gknd 1712 6 approved approve VBD cord-010119-t1x9gknd 1712 7 DNA dna NN cord-010119-t1x9gknd 1712 8 - - HYPH cord-010119-t1x9gknd 1712 9 based base VBN cord-010119-t1x9gknd 1712 10 ABO ABO NNP cord-010119-t1x9gknd 1712 11 assay assay NN cord-010119-t1x9gknd 1712 12 . . . cord-010119-t1x9gknd 1713 1 However however RB cord-010119-t1x9gknd 1713 2 , , , cord-010119-t1x9gknd 1713 3 ABO ABO NNP cord-010119-t1x9gknd 1713 4 genotyping genotyping NN cord-010119-t1x9gknd 1713 5 is be VBZ cord-010119-t1x9gknd 1713 6 a a DT cord-010119-t1x9gknd 1713 7 useful useful JJ cord-010119-t1x9gknd 1713 8 method method NN cord-010119-t1x9gknd 1713 9 for for IN cord-010119-t1x9gknd 1713 10 samples sample NNS cord-010119-t1x9gknd 1713 11 where where WRB cord-010119-t1x9gknd 1713 12 antibody antibody NN cord-010119-t1x9gknd 1713 13 tests test NNS cord-010119-t1x9gknd 1713 14 alone alone RB cord-010119-t1x9gknd 1713 15 can can MD cord-010119-t1x9gknd 1713 16 not not RB cord-010119-t1x9gknd 1713 17 be be VB cord-010119-t1x9gknd 1713 18 conclusive conclusive JJ cord-010119-t1x9gknd 1713 19 , , , cord-010119-t1x9gknd 1713 20 and and CC cord-010119-t1x9gknd 1713 21 can can MD cord-010119-t1x9gknd 1713 22 " " `` cord-010119-t1x9gknd 1713 23 rescue rescue VB cord-010119-t1x9gknd 1713 24 " " '' cord-010119-t1x9gknd 1713 25 CBU CBU NNP cord-010119-t1x9gknd 1713 26 that that WDT cord-010119-t1x9gknd 1713 27 could could MD cord-010119-t1x9gknd 1713 28 not not RB cord-010119-t1x9gknd 1713 29 be be VB cord-010119-t1x9gknd 1713 30 used use VBN cord-010119-t1x9gknd 1713 31 otherwise otherwise RB cord-010119-t1x9gknd 1713 32 . . . cord-010119-t1x9gknd 1714 1 Further further RB cord-010119-t1x9gknd 1714 2 , , , cord-010119-t1x9gknd 1714 3 genotyping genotyping NN cord-010119-t1x9gknd 1714 4 can can MD cord-010119-t1x9gknd 1714 5 help help VB cord-010119-t1x9gknd 1714 6 resolve resolve VB cord-010119-t1x9gknd 1714 7 ABO ABO NNP cord-010119-t1x9gknd 1714 8 discrepancies discrepancy NNS cord-010119-t1x9gknd 1714 9 . . . cord-010119-t1x9gknd 1715 1 ABSTRACT abstract JJ cord-010119-t1x9gknd 1715 2 cobas cobas NN cord-010119-t1x9gknd 1715 3 V v NN cord-010119-t1x9gknd 1715 4 R r NN cord-010119-t1x9gknd 1715 5 HEV hev NN cord-010119-t1x9gknd 1715 6 for for IN cord-010119-t1x9gknd 1715 7 use use NN cord-010119-t1x9gknd 1715 8 on on IN cord-010119-t1x9gknd 1715 9 the the DT cord-010119-t1x9gknd 1715 10 cobasV cobasv NN cord-010119-t1x9gknd 1716 1 R R NNP cord-010119-t1x9gknd 1716 2 6800/8800 6800/8800 CD cord-010119-t1x9gknd 1716 3 Systems Systems NNPS cord-010119-t1x9gknd 1716 4 is be VBZ cord-010119-t1x9gknd 1716 5 a a DT cord-010119-t1x9gknd 1716 6 qualitative qualitative JJ cord-010119-t1x9gknd 1716 7 PCR pcr NN cord-010119-t1x9gknd 1716 8 test test NN cord-010119-t1x9gknd 1716 9 for for IN cord-010119-t1x9gknd 1716 10 the the DT cord-010119-t1x9gknd 1716 11 detection detection NN cord-010119-t1x9gknd 1716 12 of of IN cord-010119-t1x9gknd 1716 13 HEV HEV NNP cord-010119-t1x9gknd 1716 14 RNA RNA NNP cord-010119-t1x9gknd 1716 15 in in IN cord-010119-t1x9gknd 1716 16 human human JJ cord-010119-t1x9gknd 1716 17 plasma plasma NN cord-010119-t1x9gknd 1716 18 . . . cord-010119-t1x9gknd 1717 1 The the DT cord-010119-t1x9gknd 1717 2 purpose purpose NN cord-010119-t1x9gknd 1717 3 of of IN cord-010119-t1x9gknd 1717 4 this this DT cord-010119-t1x9gknd 1717 5 study study NN cord-010119-t1x9gknd 1717 6 was be VBD cord-010119-t1x9gknd 1717 7 to to TO cord-010119-t1x9gknd 1717 8 evaluate evaluate VB cord-010119-t1x9gknd 1717 9 the the DT cord-010119-t1x9gknd 1717 10 prevalence prevalence NN cord-010119-t1x9gknd 1717 11 of of IN cord-010119-t1x9gknd 1717 12 HEV HEV NNP cord-010119-t1x9gknd 1717 13 RNA RNA NNP cord-010119-t1x9gknd 1717 14 among among IN cord-010119-t1x9gknd 1717 15 US US NNP cord-010119-t1x9gknd 1717 16 blood blood NN cord-010119-t1x9gknd 1717 17 donations donation NNS cord-010119-t1x9gknd 1717 18 collected collect VBN cord-010119-t1x9gknd 1717 19 in in IN cord-010119-t1x9gknd 1717 20 the the DT cord-010119-t1x9gknd 1717 21 Midwest Midwest NNP cord-010119-t1x9gknd 1717 22 , , , cord-010119-t1x9gknd 1717 23 a a DT cord-010119-t1x9gknd 1717 24 region region NN cord-010119-t1x9gknd 1717 25 reported report VBN cord-010119-t1x9gknd 1717 26 to to TO cord-010119-t1x9gknd 1717 27 have have VB cord-010119-t1x9gknd 1717 28 a a DT cord-010119-t1x9gknd 1717 29 higher high JJR cord-010119-t1x9gknd 1717 30 prevalence prevalence NN cord-010119-t1x9gknd 1717 31 of of IN cord-010119-t1x9gknd 1717 32 HEV HEV NNP cord-010119-t1x9gknd 1717 33 infection infection NN cord-010119-t1x9gknd 1717 34 , , , cord-010119-t1x9gknd 1717 35 and and CC cord-010119-t1x9gknd 1717 36 the the DT cord-010119-t1x9gknd 1717 37 Eastern Eastern NNP cord-010119-t1x9gknd 1717 38 US US NNP cord-010119-t1x9gknd 1717 39 . . . cord-010119-t1x9gknd 1718 1 Study Study NNP cord-010119-t1x9gknd 1718 2 Design Design NNP cord-010119-t1x9gknd 1718 3 / / SYM cord-010119-t1x9gknd 1718 4 Methods method NNS cord-010119-t1x9gknd 1718 5 : : : cord-010119-t1x9gknd 1718 6 30,695 30,695 CD cord-010119-t1x9gknd 1718 7 fresh fresh JJ cord-010119-t1x9gknd 1718 8 and and CC cord-010119-t1x9gknd 1718 9 20,029 20,029 CD cord-010119-t1x9gknd 1718 10 frozen frozen JJ cord-010119-t1x9gknd 1718 11 EDTA edta NN cord-010119-t1x9gknd 1718 12 plasma plasma NN cord-010119-t1x9gknd 1718 13 samples sample NNS cord-010119-t1x9gknd 1718 14 from from IN cord-010119-t1x9gknd 1718 15 American American NNP cord-010119-t1x9gknd 1718 16 Red Red NNP cord-010119-t1x9gknd 1718 17 Cross Cross NNP cord-010119-t1x9gknd 1718 18 donors donor NNS cord-010119-t1x9gknd 1718 19 , , , cord-010119-t1x9gknd 1718 20 collected collect VBN cord-010119-t1x9gknd 1718 21 from from IN cord-010119-t1x9gknd 1718 22 February February NNP cord-010119-t1x9gknd 1718 23 2015 2015 CD cord-010119-t1x9gknd 1718 24 - - SYM cord-010119-t1x9gknd 1718 25 2016 2016 CD cord-010119-t1x9gknd 1718 26 , , , cord-010119-t1x9gknd 1718 27 were be VBD cord-010119-t1x9gknd 1718 28 de de VBN cord-010119-t1x9gknd 1718 29 - - VBN cord-010119-t1x9gknd 1718 30 identified identify VBN cord-010119-t1x9gknd 1718 31 and and CC cord-010119-t1x9gknd 1718 32 screened screen VBN cord-010119-t1x9gknd 1718 33 by by IN cord-010119-t1x9gknd 1718 34 individual individual JJ cord-010119-t1x9gknd 1718 35 donation donation NN cord-010119-t1x9gknd 1718 36 testing testing NN cord-010119-t1x9gknd 1718 37 ( ( -LRB- cord-010119-t1x9gknd 1718 38 ID ID NNP cord-010119-t1x9gknd 1718 39 - - HYPH cord-010119-t1x9gknd 1718 40 NAT NAT NNP cord-010119-t1x9gknd 1718 41 ) ) -RRB- cord-010119-t1x9gknd 1718 42 using use VBG cord-010119-t1x9gknd 1718 43 cobasV cobasv NN cord-010119-t1x9gknd 1718 44 R r NN cord-010119-t1x9gknd 1718 45 HEV hev NN cord-010119-t1x9gknd 1718 46 for for IN cord-010119-t1x9gknd 1718 47 use use NN cord-010119-t1x9gknd 1718 48 on on IN cord-010119-t1x9gknd 1718 49 the the DT cord-010119-t1x9gknd 1718 50 cobasV cobasv NN cord-010119-t1x9gknd 1718 51 R r NN cord-010119-t1x9gknd 1718 52 8800 8800 CD cord-010119-t1x9gknd 1718 53 System system NN cord-010119-t1x9gknd 1718 54 under under IN cord-010119-t1x9gknd 1718 55 a a DT cord-010119-t1x9gknd 1718 56 research research NN cord-010119-t1x9gknd 1718 57 protocol protocol NN cord-010119-t1x9gknd 1718 58 . . . cord-010119-t1x9gknd 1719 1 Samples sample NNS cord-010119-t1x9gknd 1719 2 were be VBD cord-010119-t1x9gknd 1719 3 primarily primarily RB cord-010119-t1x9gknd 1719 4 from from IN cord-010119-t1x9gknd 1719 5 Midwestern midwestern JJ cord-010119-t1x9gknd 1719 6 and and CC cord-010119-t1x9gknd 1719 7 Eastern eastern JJ cord-010119-t1x9gknd 1719 8 regions region NNS cord-010119-t1x9gknd 1719 9 of of IN cord-010119-t1x9gknd 1719 10 the the DT cord-010119-t1x9gknd 1719 11 US US NNP cord-010119-t1x9gknd 1719 12 . . . cord-010119-t1x9gknd 1720 1 Samples sample NNS cord-010119-t1x9gknd 1720 2 reactive reactive JJ cord-010119-t1x9gknd 1720 3 on on IN cord-010119-t1x9gknd 1720 4 cobasV cobasv NN cord-010119-t1x9gknd 1720 5 R r NN cord-010119-t1x9gknd 1720 6 HEV hev NN cord-010119-t1x9gknd 1720 7 were be VBD cord-010119-t1x9gknd 1720 8 further further RB cord-010119-t1x9gknd 1720 9 tested test VBN cord-010119-t1x9gknd 1720 10 by by IN cord-010119-t1x9gknd 1720 11 an an DT cord-010119-t1x9gknd 1720 12 alternate alternate JJ cord-010119-t1x9gknd 1720 13 HEV HEV NNP cord-010119-t1x9gknd 1720 14 NAT NAT NNP cord-010119-t1x9gknd 1720 15 , , , cord-010119-t1x9gknd 1720 16 HEV HEV NNP cord-010119-t1x9gknd 1720 17 RNA RNA NNP cord-010119-t1x9gknd 1720 18 quantitation quantitation NN cord-010119-t1x9gknd 1720 19 , , , cord-010119-t1x9gknd 1720 20 HEV HEV NNP cord-010119-t1x9gknd 1720 21 genotyping genotyping NN cord-010119-t1x9gknd 1720 22 , , , cord-010119-t1x9gknd 1720 23 and and CC cord-010119-t1x9gknd 1720 24 for for IN cord-010119-t1x9gknd 1720 25 HEV HEV NNP cord-010119-t1x9gknd 1720 26 antibodies antibody NNS cord-010119-t1x9gknd 1720 27 . . . cord-010119-t1x9gknd 1721 1 Results result NNS cord-010119-t1x9gknd 1721 2 / / SYM cord-010119-t1x9gknd 1721 3 Findings finding NNS cord-010119-t1x9gknd 1721 4 : : : cord-010119-t1x9gknd 1721 5 Of of IN cord-010119-t1x9gknd 1721 6 50,724 50,724 CD cord-010119-t1x9gknd 1721 7 valid valid JJ cord-010119-t1x9gknd 1721 8 results result NNS cord-010119-t1x9gknd 1722 1 , , , cord-010119-t1x9gknd 1722 2 a a DT cord-010119-t1x9gknd 1722 3 total total NN cord-010119-t1x9gknd 1722 4 of of IN cord-010119-t1x9gknd 1722 5 3 3 CD cord-010119-t1x9gknd 1722 6 donations donation NNS cord-010119-t1x9gknd 1722 7 were be VBD cord-010119-t1x9gknd 1722 8 reactive reactive JJ cord-010119-t1x9gknd 1722 9 on on IN cord-010119-t1x9gknd 1722 10 cobasV cobasv NN cord-010119-t1x9gknd 1722 11 R r NN cord-010119-t1x9gknd 1722 12 HEV hev NN cord-010119-t1x9gknd 1722 13 and and CC cord-010119-t1x9gknd 1722 14 all all DT cord-010119-t1x9gknd 1722 15 were be VBD cord-010119-t1x9gknd 1722 16 confirmed confirm VBN cord-010119-t1x9gknd 1722 17 positive positive JJ cord-010119-t1x9gknd 1722 18 . . . cord-010119-t1x9gknd 1723 1 The the DT cord-010119-t1x9gknd 1723 2 confirmed confirm VBN cord-010119-t1x9gknd 1723 3 donations donation NNS cord-010119-t1x9gknd 1723 4 were be VBD cord-010119-t1x9gknd 1723 5 from from IN cord-010119-t1x9gknd 1723 6 a a DT cord-010119-t1x9gknd 1723 7 65-year 65-year JJ cord-010119-t1x9gknd 1723 8 old old JJ cord-010119-t1x9gknd 1723 9 male male NN cord-010119-t1x9gknd 1723 10 in in IN cord-010119-t1x9gknd 1723 11 Indiana Indiana NNP cord-010119-t1x9gknd 1723 12 , , , cord-010119-t1x9gknd 1723 13 a a DT cord-010119-t1x9gknd 1723 14 21-year 21-year JJ cord-010119-t1x9gknd 1723 15 old old JJ cord-010119-t1x9gknd 1723 16 male male NN cord-010119-t1x9gknd 1723 17 in in IN cord-010119-t1x9gknd 1723 18 California California NNP cord-010119-t1x9gknd 1723 19 , , , cord-010119-t1x9gknd 1723 20 and and CC cord-010119-t1x9gknd 1723 21 a a DT cord-010119-t1x9gknd 1723 22 55-year 55-year JJ cord-010119-t1x9gknd 1723 23 old old JJ cord-010119-t1x9gknd 1723 24 female female NN cord-010119-t1x9gknd 1723 25 in in IN cord-010119-t1x9gknd 1723 26 Kentucky Kentucky NNP cord-010119-t1x9gknd 1723 27 . . . cord-010119-t1x9gknd 1724 1 All all DT cord-010119-t1x9gknd 1724 2 3 3 CD cord-010119-t1x9gknd 1724 3 donations donation NNS cord-010119-t1x9gknd 1724 4 were be VBD cord-010119-t1x9gknd 1724 5 positive positive JJ cord-010119-t1x9gknd 1724 6 by by IN cord-010119-t1x9gknd 1724 7 hemi hemi NNP cord-010119-t1x9gknd 1724 8 - - HYPH cord-010119-t1x9gknd 1724 9 nested nest VBN cord-010119-t1x9gknd 1724 10 PCR PCR NNP cord-010119-t1x9gknd 1724 11 and and CC cord-010119-t1x9gknd 1724 12 alternative alternative JJ cord-010119-t1x9gknd 1724 13 HEV HEV NNP cord-010119-t1x9gknd 1724 14 NAT NAT NNP cord-010119-t1x9gknd 1724 15 ; ; : cord-010119-t1x9gknd 1724 16 however however RB cord-010119-t1x9gknd 1724 17 , , , cord-010119-t1x9gknd 1724 18 only only RB cord-010119-t1x9gknd 1724 19 the the DT cord-010119-t1x9gknd 1724 20 Kentucky Kentucky NNP cord-010119-t1x9gknd 1724 21 donation donation NN cord-010119-t1x9gknd 1724 22 had have VBD cord-010119-t1x9gknd 1724 23 a a DT cord-010119-t1x9gknd 1724 24 high high JJ cord-010119-t1x9gknd 1724 25 level level NN cord-010119-t1x9gknd 1724 26 of of IN cord-010119-t1x9gknd 1724 27 HEV HEV NNP cord-010119-t1x9gknd 1724 28 RNA RNA NNP cord-010119-t1x9gknd 1724 29 ( ( -LRB- cord-010119-t1x9gknd 1724 30 1440 1440 CD cord-010119-t1x9gknd 1724 31 IU IU NNP cord-010119-t1x9gknd 1724 32 / / SYM cord-010119-t1x9gknd 1724 33 mL mL NNP cord-010119-t1x9gknd 1724 34 ) ) -RRB- cord-010119-t1x9gknd 1724 35 , , , cord-010119-t1x9gknd 1724 36 and and CC cord-010119-t1x9gknd 1724 37 was be VBD cord-010119-t1x9gknd 1724 38 strongly strongly RB cord-010119-t1x9gknd 1724 39 positive positive JJ cord-010119-t1x9gknd 1724 40 for for IN cord-010119-t1x9gknd 1724 41 both both DT cord-010119-t1x9gknd 1724 42 IgM IgM NNP cord-010119-t1x9gknd 1724 43 and and CC cord-010119-t1x9gknd 1724 44 IgG IgG NNP cord-010119-t1x9gknd 1724 45 HEV HEV NNP cord-010119-t1x9gknd 1724 46 antibodies antibody NNS cord-010119-t1x9gknd 1724 47 . . . cord-010119-t1x9gknd 1725 1 The the DT cord-010119-t1x9gknd 1725 2 Indiana Indiana NNP cord-010119-t1x9gknd 1725 3 donation donation NN cord-010119-t1x9gknd 1725 4 was be VBD cord-010119-t1x9gknd 1725 5 genotyped genotype VBN cord-010119-t1x9gknd 1725 6 as as IN cord-010119-t1x9gknd 1725 7 3a 3a NNP cord-010119-t1x9gknd 1725 8 , , , cord-010119-t1x9gknd 1725 9 the the DT cord-010119-t1x9gknd 1725 10 California California NNP cord-010119-t1x9gknd 1725 11 donation donation NN cord-010119-t1x9gknd 1725 12 genotype genotype NN cord-010119-t1x9gknd 1725 13 3b 3b CD cord-010119-t1x9gknd 1725 14 , , , cord-010119-t1x9gknd 1725 15 and and CC cord-010119-t1x9gknd 1725 16 no no DT cord-010119-t1x9gknd 1725 17 genotype genotype NN cord-010119-t1x9gknd 1725 18 determined determine VBN cord-010119-t1x9gknd 1725 19 for for IN cord-010119-t1x9gknd 1725 20 the the DT cord-010119-t1x9gknd 1725 21 Kentucky Kentucky NNP cord-010119-t1x9gknd 1725 22 donation donation NN cord-010119-t1x9gknd 1725 23 ( ( -LRB- cord-010119-t1x9gknd 1725 24 see see VB cord-010119-t1x9gknd 1725 25 Table table NN cord-010119-t1x9gknd 1725 26 ) ) -RRB- cord-010119-t1x9gknd 1725 27 . . . cord-010119-t1x9gknd 1726 1 The the DT cord-010119-t1x9gknd 1726 2 clinical clinical JJ cord-010119-t1x9gknd 1726 3 specificity specificity NN cord-010119-t1x9gknd 1726 4 for for IN cord-010119-t1x9gknd 1726 5 the the DT cord-010119-t1x9gknd 1726 6 cobasV cobasv NN cord-010119-t1x9gknd 1726 7 R r NN cord-010119-t1x9gknd 1726 8 HEV hev NN cord-010119-t1x9gknd 1726 9 test test NN cord-010119-t1x9gknd 1726 10 in in IN cord-010119-t1x9gknd 1726 11 ID ID NNP cord-010119-t1x9gknd 1726 12 - - HYPH cord-010119-t1x9gknd 1726 13 NAT NAT NNP cord-010119-t1x9gknd 1726 14 was be VBD cord-010119-t1x9gknd 1726 15 100 100 CD cord-010119-t1x9gknd 1726 16 % % NN cord-010119-t1x9gknd 1726 17 ( ( -LRB- cord-010119-t1x9gknd 1726 18 95 95 CD cord-010119-t1x9gknd 1726 19 % % NN cord-010119-t1x9gknd 1726 20 exact exact JJ cord-010119-t1x9gknd 1726 21 CI ci NN cord-010119-t1x9gknd 1726 22 : : : cord-010119-t1x9gknd 1727 1 99.993 99.993 CD cord-010119-t1x9gknd 1727 2 % % NN cord-010119-t1x9gknd 1727 3 to to IN cord-010119-t1x9gknd 1727 4 100 100 CD cord-010119-t1x9gknd 1727 5 % % NN cord-010119-t1x9gknd 1727 6 ) ) -RRB- cord-010119-t1x9gknd 1727 7 . . . cord-010119-t1x9gknd 1728 1 Conclusion conclusion NN cord-010119-t1x9gknd 1728 2 : : : cord-010119-t1x9gknd 1729 1 Based base VBN cord-010119-t1x9gknd 1729 2 on on IN cord-010119-t1x9gknd 1729 3 the the DT cord-010119-t1x9gknd 1729 4 3 3 CD cord-010119-t1x9gknd 1729 5 confirmed confirm VBN cord-010119-t1x9gknd 1729 6 - - HYPH cord-010119-t1x9gknd 1729 7 positive positive JJ cord-010119-t1x9gknd 1729 8 donations donation NNS cord-010119-t1x9gknd 1729 9 of of IN cord-010119-t1x9gknd 1729 10 50,724 50,724 CD cord-010119-t1x9gknd 1729 11 tested test VBN cord-010119-t1x9gknd 1729 12 , , , cord-010119-t1x9gknd 1729 13 the the DT cord-010119-t1x9gknd 1729 14 HEV HEV NNP cord-010119-t1x9gknd 1729 15 prevalence prevalence NN cord-010119-t1x9gknd 1729 16 was be VBD cord-010119-t1x9gknd 1729 17 0.006 0.006 CD cord-010119-t1x9gknd 1729 18 % % NN cord-010119-t1x9gknd 1729 19 ( ( -LRB- cord-010119-t1x9gknd 1729 20 95 95 CD cord-010119-t1x9gknd 1729 21 % % NN cord-010119-t1x9gknd 1729 22 exact exact JJ cord-010119-t1x9gknd 1729 23 CI ci NN cord-010119-t1x9gknd 1729 24 : : : cord-010119-t1x9gknd 1729 25 0.001 0.001 CD cord-010119-t1x9gknd 1729 26 % % NN cord-010119-t1x9gknd 1729 27 to to IN cord-010119-t1x9gknd 1729 28 0.017 0.017 CD cord-010119-t1x9gknd 1729 29 % % NN cord-010119-t1x9gknd 1729 30 ) ) -RRB- cord-010119-t1x9gknd 1729 31 with with IN cord-010119-t1x9gknd 1729 32 a a DT cord-010119-t1x9gknd 1729 33 detection detection NN cord-010119-t1x9gknd 1729 34 rate rate NN cord-010119-t1x9gknd 1729 35 of of IN cord-010119-t1x9gknd 1729 36 1:16,667 1:16,667 CD cord-010119-t1x9gknd 1730 1 ( ( -LRB- cord-010119-t1x9gknd 1730 2 95 95 CD cord-010119-t1x9gknd 1730 3 % % NN cord-010119-t1x9gknd 1730 4 CI CI NNP cord-010119-t1x9gknd 1730 5 , , , cord-010119-t1x9gknd 1730 6 1:588 1:588 CD cord-010119-t1x9gknd 1730 7 - - HYPH cord-010119-t1x9gknd 1730 8 1:100,000 1:100,000 CD cord-010119-t1x9gknd 1730 9 ) ) -RRB- cord-010119-t1x9gknd 1730 10 . . . cord-010119-t1x9gknd 1731 1 To to IN cord-010119-t1x9gknd 1731 2 date date NN cord-010119-t1x9gknd 1731 3 , , , cord-010119-t1x9gknd 1731 4 no no DT cord-010119-t1x9gknd 1731 5 cases case NNS cord-010119-t1x9gknd 1731 6 of of IN cord-010119-t1x9gknd 1731 7 TT TT NNP cord-010119-t1x9gknd 1731 8 - - HYPH cord-010119-t1x9gknd 1731 9 HEV HEV NNP cord-010119-t1x9gknd 1731 10 have have VBP cord-010119-t1x9gknd 1731 11 been be VBN cord-010119-t1x9gknd 1731 12 documented document VBN cord-010119-t1x9gknd 1731 13 in in IN cord-010119-t1x9gknd 1731 14 the the DT cord-010119-t1x9gknd 1731 15 US US NNP cord-010119-t1x9gknd 1731 16 . . . cord-010119-t1x9gknd 1732 1 However however RB cord-010119-t1x9gknd 1732 2 , , , cord-010119-t1x9gknd 1732 3 based base VBN cord-010119-t1x9gknd 1732 4 on on IN cord-010119-t1x9gknd 1732 5 the the DT cord-010119-t1x9gknd 1732 6 prevalence prevalence NN cord-010119-t1x9gknd 1732 7 observed observe VBN cord-010119-t1x9gknd 1732 8 , , , cord-010119-t1x9gknd 1732 9 immunosuppressed immunosuppressed JJ cord-010119-t1x9gknd 1732 10 transfusion transfusion NN cord-010119-t1x9gknd 1732 11 recipients recipient NNS cord-010119-t1x9gknd 1732 12 may may MD cord-010119-t1x9gknd 1732 13 be be VB cord-010119-t1x9gknd 1732 14 at at IN cord-010119-t1x9gknd 1732 15 increased increase VBN cord-010119-t1x9gknd 1732 16 risk risk NN cord-010119-t1x9gknd 1732 17 for for IN cord-010119-t1x9gknd 1732 18 transfusion transfusion NN cord-010119-t1x9gknd 1732 19 - - HYPH cord-010119-t1x9gknd 1732 20 transmitted transmit VBN cord-010119-t1x9gknd 1732 21 HEV hev NN cord-010119-t1x9gknd 1732 22 . . . cord-010119-t1x9gknd 1733 1 Background Background NNP cord-010119-t1x9gknd 1733 2 / / SYM cord-010119-t1x9gknd 1733 3 Case Case NNP cord-010119-t1x9gknd 1733 4 Studies Studies NNPS cord-010119-t1x9gknd 1733 5 : : : cord-010119-t1x9gknd 1733 6 Monitoring monitor VBG cord-010119-t1x9gknd 1733 7 the the DT cord-010119-t1x9gknd 1733 8 epidemiology epidemiology NN cord-010119-t1x9gknd 1733 9 of of IN cord-010119-t1x9gknd 1733 10 TTIs tti NNS cord-010119-t1x9gknd 1733 11 within within IN cord-010119-t1x9gknd 1733 12 the the DT cord-010119-t1x9gknd 1733 13 donor donor NN cord-010119-t1x9gknd 1733 14 population population NN cord-010119-t1x9gknd 1733 15 is be VBZ cord-010119-t1x9gknd 1733 16 critical critical JJ cord-010119-t1x9gknd 1733 17 to to TO cord-010119-t1x9gknd 1733 18 provide provide VB cord-010119-t1x9gknd 1733 19 an an DT cord-010119-t1x9gknd 1733 20 ongoing ongoing JJ cord-010119-t1x9gknd 1733 21 assessment assessment NN cord-010119-t1x9gknd 1733 22 of of IN cord-010119-t1x9gknd 1733 23 infection infection NN cord-010119-t1x9gknd 1733 24 risks risk NNS cord-010119-t1x9gknd 1733 25 associated associate VBN cord-010119-t1x9gknd 1733 26 with with IN cord-010119-t1x9gknd 1733 27 FDA FDA NNP cord-010119-t1x9gknd 1733 28 policy policy NN cord-010119-t1x9gknd 1733 29 changes change NNS cord-010119-t1x9gknd 1733 30 such such JJ cord-010119-t1x9gknd 1733 31 as as IN cord-010119-t1x9gknd 1733 32 the the DT cord-010119-t1x9gknd 1733 33 MSM MSM NNP cord-010119-t1x9gknd 1733 34 deferral deferral NN cord-010119-t1x9gknd 1733 35 criteria criterion NNS cord-010119-t1x9gknd 1733 36 . . . cord-010119-t1x9gknd 1734 1 TTIMS TTIMS NNP cord-010119-t1x9gknd 1734 2 is be VBZ cord-010119-t1x9gknd 1734 3 a a DT cord-010119-t1x9gknd 1734 4 multi multi JJ cord-010119-t1x9gknd 1734 5 - - JJ cord-010119-t1x9gknd 1734 6 center center JJ cord-010119-t1x9gknd 1734 7 , , , cord-010119-t1x9gknd 1734 8 federally federally RB cord-010119-t1x9gknd 1734 9 - - HYPH cord-010119-t1x9gknd 1734 10 funded fund VBN cord-010119-t1x9gknd 1734 11 program program NN cord-010119-t1x9gknd 1734 12 intended intend VBN cord-010119-t1x9gknd 1734 13 to to TO cord-010119-t1x9gknd 1734 14 derive derive VB cord-010119-t1x9gknd 1734 15 HBV HBV NNP cord-010119-t1x9gknd 1734 16 , , , cord-010119-t1x9gknd 1734 17 HCV HCV NNP cord-010119-t1x9gknd 1734 18 and and CC cord-010119-t1x9gknd 1734 19 HIV HIV NNP cord-010119-t1x9gknd 1734 20 prevalence prevalence NN cord-010119-t1x9gknd 1734 21 , , , cord-010119-t1x9gknd 1734 22 incidence incidence NN cord-010119-t1x9gknd 1734 23 , , , cord-010119-t1x9gknd 1734 24 viral viral JJ cord-010119-t1x9gknd 1734 25 genotypes genotype NNS cord-010119-t1x9gknd 1734 26 , , , cord-010119-t1x9gknd 1734 27 and and CC cord-010119-t1x9gknd 1734 28 donor donor NN cord-010119-t1x9gknd 1734 29 risk risk NN cord-010119-t1x9gknd 1734 30 factors factor NNS cord-010119-t1x9gknd 1734 31 for for IN cord-010119-t1x9gknd 1734 32 greater great JJR cord-010119-t1x9gknd 1734 33 than than IN cord-010119-t1x9gknd 1734 34 50 50 CD cord-010119-t1x9gknd 1734 35 % % NN cord-010119-t1x9gknd 1734 36 of of IN cord-010119-t1x9gknd 1734 37 blood blood NN cord-010119-t1x9gknd 1734 38 collected collect VBN cord-010119-t1x9gknd 1734 39 in in IN cord-010119-t1x9gknd 1734 40 the the DT cord-010119-t1x9gknd 1734 41 US US NNP cord-010119-t1x9gknd 1734 42 . . . cord-010119-t1x9gknd 1735 1 TTIMS TTIMS NNP cord-010119-t1x9gknd 1735 2 is be VBZ cord-010119-t1x9gknd 1735 3 supported support VBN cord-010119-t1x9gknd 1735 4 by by IN cord-010119-t1x9gknd 1735 5 two two CD cord-010119-t1x9gknd 1735 6 distinct distinct JJ cord-010119-t1x9gknd 1735 7 coordinating coordinate VBG cord-010119-t1x9gknd 1735 8 centers center NNS cord-010119-t1x9gknd 1735 9 ( ( -LRB- cord-010119-t1x9gknd 1735 10 laboratory laboratory NN cord-010119-t1x9gknd 1735 11 and and CC cord-010119-t1x9gknd 1735 12 risk risk NN cord-010119-t1x9gknd 1735 13 factor factor NN cord-010119-t1x9gknd 1735 14 , , , cord-010119-t1x9gknd 1735 15 LRCC LRCC NNP cord-010119-t1x9gknd 1735 16 , , , cord-010119-t1x9gknd 1735 17 and and CC cord-010119-t1x9gknd 1735 18 donation donation NN cord-010119-t1x9gknd 1735 19 database database NN cord-010119-t1x9gknd 1735 20 , , , cord-010119-t1x9gknd 1735 21 DDCC DDCC NNP cord-010119-t1x9gknd 1735 22 ) ) -RRB- cord-010119-t1x9gknd 1735 23 . . . cord-010119-t1x9gknd 1736 1 Here here RB cord-010119-t1x9gknd 1736 2 we -PRON- PRP cord-010119-t1x9gknd 1736 3 report report VBP cord-010119-t1x9gknd 1736 4 13 13 CD cord-010119-t1x9gknd 1736 5 months month NNS cord-010119-t1x9gknd 1736 6 of of IN cord-010119-t1x9gknd 1736 7 prevalence prevalence NN cord-010119-t1x9gknd 1736 8 along along IN cord-010119-t1x9gknd 1736 9 with with IN cord-010119-t1x9gknd 1736 10 demographic demographic JJ cord-010119-t1x9gknd 1736 11 trends trend NNS cord-010119-t1x9gknd 1736 12 from from IN cord-010119-t1x9gknd 1736 13 the the DT cord-010119-t1x9gknd 1736 14 DDCC DDCC NNP cord-010119-t1x9gknd 1736 15 . . . cord-010119-t1x9gknd 1737 1 Study Study NNP cord-010119-t1x9gknd 1737 2 Design Design NNP cord-010119-t1x9gknd 1737 3 / / SYM cord-010119-t1x9gknd 1737 4 Methods method NNS cord-010119-t1x9gknd 1737 5 : : : cord-010119-t1x9gknd 1738 1 Four four CD cord-010119-t1x9gknd 1738 2 blood blood NN cord-010119-t1x9gknd 1738 3 providers provider NNS cord-010119-t1x9gknd 1738 4 and and CC cord-010119-t1x9gknd 1738 5 their -PRON- PRP$ cord-010119-t1x9gknd 1738 6 respective respective JJ cord-010119-t1x9gknd 1738 7 testing testing NN cord-010119-t1x9gknd 1738 8 laboratories laboratory NNS cord-010119-t1x9gknd 1738 9 participated participate VBD cord-010119-t1x9gknd 1738 10 . . . cord-010119-t1x9gknd 1739 1 Standardized standardized JJ cord-010119-t1x9gknd 1739 2 consensus consensus NN cord-010119-t1x9gknd 1739 3 - - HYPH cord-010119-t1x9gknd 1739 4 positive positive JJ cord-010119-t1x9gknd 1739 5 ( ( -LRB- cord-010119-t1x9gknd 1739 6 CP cp NN cord-010119-t1x9gknd 1739 7 ) ) -RRB- cord-010119-t1x9gknd 1739 8 monitoring monitoring NN cord-010119-t1x9gknd 1739 9 definitions definition NNS cord-010119-t1x9gknd 1739 10 were be VBD cord-010119-t1x9gknd 1739 11 established establish VBN cord-010119-t1x9gknd 1739 12 for for IN cord-010119-t1x9gknd 1739 13 donor donor NN cord-010119-t1x9gknd 1739 14 test test NN cord-010119-t1x9gknd 1739 15 results result NNS cord-010119-t1x9gknd 1739 16 for for IN cord-010119-t1x9gknd 1739 17 HBV HBV NNP cord-010119-t1x9gknd 1739 18 , , , cord-010119-t1x9gknd 1739 19 HCV HCV NNP cord-010119-t1x9gknd 1739 20 and and CC cord-010119-t1x9gknd 1739 21 HIV HIV NNP cord-010119-t1x9gknd 1739 22 . . . cord-010119-t1x9gknd 1740 1 These these DT cord-010119-t1x9gknd 1740 2 results result NNS cord-010119-t1x9gknd 1740 3 , , , cord-010119-t1x9gknd 1740 4 along along IN cord-010119-t1x9gknd 1740 5 with with IN cord-010119-t1x9gknd 1740 6 demographics demographic NNS cord-010119-t1x9gknd 1740 7 for for IN cord-010119-t1x9gknd 1740 8 each each DT cord-010119-t1x9gknd 1740 9 donor donor NN cord-010119-t1x9gknd 1740 10 and and CC cord-010119-t1x9gknd 1740 11 donation donation NN cord-010119-t1x9gknd 1740 12 status status NN cord-010119-t1x9gknd 1740 13 ( ( -LRB- cord-010119-t1x9gknd 1740 14 first first JJ cord-010119-t1x9gknd 1740 15 - - HYPH cord-010119-t1x9gknd 1740 16 time time NN cord-010119-t1x9gknd 1740 17 vs vs IN cord-010119-t1x9gknd 1740 18 repeat repeat NN cord-010119-t1x9gknd 1740 19 ) ) -RRB- cord-010119-t1x9gknd 1740 20 were be VBD cord-010119-t1x9gknd 1740 21 assembled assemble VBN cord-010119-t1x9gknd 1740 22 into into IN cord-010119-t1x9gknd 1740 23 a a DT cord-010119-t1x9gknd 1740 24 single single JJ cord-010119-t1x9gknd 1740 25 data data NN cord-010119-t1x9gknd 1740 26 set set NN cord-010119-t1x9gknd 1740 27 . . . cord-010119-t1x9gknd 1741 1 Rates rate NNS cord-010119-t1x9gknd 1741 2 of of IN cord-010119-t1x9gknd 1741 3 nucleic nucleic JJ cord-010119-t1x9gknd 1741 4 acid acid NN cord-010119-t1x9gknd 1741 5 test test NN cord-010119-t1x9gknd 1741 6 ( ( -LRB- cord-010119-t1x9gknd 1741 7 NAT NAT NNP cord-010119-t1x9gknd 1741 8 ) ) -RRB- cord-010119-t1x9gknd 1741 9 yield yield NN cord-010119-t1x9gknd 1741 10 ( ( -LRB- cord-010119-t1x9gknd 1741 11 seronegative seronegative JJ cord-010119-t1x9gknd 1741 12 ) ) -RRB- cord-010119-t1x9gknd 1741 13 and and CC cord-010119-t1x9gknd 1741 14 concordant concordant JJ cord-010119-t1x9gknd 1741 15 positives positive NNS cord-010119-t1x9gknd 1741 16 ( ( -LRB- cord-010119-t1x9gknd 1741 17 serologic serologic NNP cord-010119-t1x9gknd 1741 18 plus plus CC cord-010119-t1x9gknd 1741 19 NAT NAT NNP cord-010119-t1x9gknd 1741 20 positives positive NNS cord-010119-t1x9gknd 1741 21 ) ) -RRB- cord-010119-t1x9gknd 1742 1 were be VBD cord-010119-t1x9gknd 1742 2 combined combine VBN cord-010119-t1x9gknd 1742 3 to to TO cord-010119-t1x9gknd 1742 4 comprise comprise VB cord-010119-t1x9gknd 1742 5 CPs cp NNS cord-010119-t1x9gknd 1742 6 , , , cord-010119-t1x9gknd 1742 7 were be VBD cord-010119-t1x9gknd 1742 8 computed compute VBN cord-010119-t1x9gknd 1742 9 overall overall RB cord-010119-t1x9gknd 1742 10 for for IN cord-010119-t1x9gknd 1742 11 donors donor NNS cord-010119-t1x9gknd 1742 12 and and CC cord-010119-t1x9gknd 1742 13 donations donation NNS cord-010119-t1x9gknd 1742 14 and and CC cord-010119-t1x9gknd 1742 15 by by IN cord-010119-t1x9gknd 1742 16 demographic demographic JJ cord-010119-t1x9gknd 1742 17 , , , cord-010119-t1x9gknd 1742 18 geographic geographic JJ cord-010119-t1x9gknd 1742 19 and and CC cord-010119-t1x9gknd 1742 20 temporal temporal JJ cord-010119-t1x9gknd 1742 21 characteristics characteristic NNS cord-010119-t1x9gknd 1742 22 . . . cord-010119-t1x9gknd 1743 1 Where where WRB cord-010119-t1x9gknd 1743 2 appropriate appropriate JJ cord-010119-t1x9gknd 1743 3 , , , cord-010119-t1x9gknd 1743 4 rates rate NNS cord-010119-t1x9gknd 1743 5 were be VBD cord-010119-t1x9gknd 1743 6 compared compare VBN cord-010119-t1x9gknd 1743 7 for for IN cord-010119-t1x9gknd 1743 8 differences difference NNS cord-010119-t1x9gknd 1743 9 using use VBG cord-010119-t1x9gknd 1743 10 95 95 CD cord-010119-t1x9gknd 1743 11 % % NN cord-010119-t1x9gknd 1743 12 confidence confidence NN cord-010119-t1x9gknd 1743 13 intervals interval NNS cord-010119-t1x9gknd 1743 14 . . . cord-010119-t1x9gknd 1744 1 This this DT cord-010119-t1x9gknd 1744 2 analysis analysis NN cord-010119-t1x9gknd 1744 3 contains contain VBZ cord-010119-t1x9gknd 1744 4 data datum NNS cord-010119-t1x9gknd 1744 5 from from IN cord-010119-t1x9gknd 1744 6 9/1/15 9/1/15 CD cord-010119-t1x9gknd 1744 7 - - HYPH cord-010119-t1x9gknd 1744 8 9/30/16 9/30/16 CD cord-010119-t1x9gknd 1744 9 . . . cord-010119-t1x9gknd 1745 1 Results result NNS cord-010119-t1x9gknd 1745 2 / / SYM cord-010119-t1x9gknd 1745 3 Findings finding NNS cord-010119-t1x9gknd 1745 4 : : : cord-010119-t1x9gknd 1746 1 Among among IN cord-010119-t1x9gknd 1746 2 7,578,462 7,578,462 CD cord-010119-t1x9gknd 1746 3 donations donation NNS cord-010119-t1x9gknd 1746 4 reported report VBN cord-010119-t1x9gknd 1746 5 ( ( -LRB- cord-010119-t1x9gknd 1746 6 16.2 16.2 CD cord-010119-t1x9gknd 1746 7 % % NN cord-010119-t1x9gknd 1746 8 from from IN cord-010119-t1x9gknd 1746 9 firsttime firsttime NN cord-010119-t1x9gknd 1746 10 and and CC cord-010119-t1x9gknd 1746 11 83.8 83.8 CD cord-010119-t1x9gknd 1746 12 % % NN cord-010119-t1x9gknd 1746 13 from from IN cord-010119-t1x9gknd 1746 14 repeat repeat NN cord-010119-t1x9gknd 1746 15 donors donor NNS cord-010119-t1x9gknd 1746 16 ) ) -RRB- cord-010119-t1x9gknd 1746 17 , , , cord-010119-t1x9gknd 1746 18 there there EX cord-010119-t1x9gknd 1746 19 were be VBD cord-010119-t1x9gknd 1746 20 respectively respectively RB cord-010119-t1x9gknd 1746 21 483 483 CD cord-010119-t1x9gknd 1746 22 , , , cord-010119-t1x9gknd 1746 23 1489 1489 CD cord-010119-t1x9gknd 1746 24 and and CC cord-010119-t1x9gknd 1746 25 194 194 CD cord-010119-t1x9gknd 1746 26 CP cp NN cord-010119-t1x9gknd 1746 27 results result NNS cord-010119-t1x9gknd 1746 28 for for IN cord-010119-t1x9gknd 1746 29 HBV HBV NNP cord-010119-t1x9gknd 1746 30 , , , cord-010119-t1x9gknd 1746 31 HCV HCV NNP cord-010119-t1x9gknd 1746 32 and and CC cord-010119-t1x9gknd 1746 33 HIV HIV NNP cord-010119-t1x9gknd 1746 34 with with IN cord-010119-t1x9gknd 1746 35 corresponding correspond VBG cord-010119-t1x9gknd 1746 36 rates rate NNS cord-010119-t1x9gknd 1746 37 of of IN cord-010119-t1x9gknd 1746 38 6.37,19.63 6.37,19.63 CD cord-010119-t1x9gknd 1746 39 and and CC cord-010119-t1x9gknd 1746 40 2.56 2.56 CD cord-010119-t1x9gknd 1746 41 per per IN cord-010119-t1x9gknd 1746 42 100,000 100,000 CD cord-010119-t1x9gknd 1746 43 ( ( -LRB- cord-010119-t1x9gknd 1746 44 pht pht NNP cord-010119-t1x9gknd 1746 45 ) ) -RRB- cord-010119-t1x9gknd 1746 46 donations donation NNS cord-010119-t1x9gknd 1746 47 . . . cord-010119-t1x9gknd 1747 1 Prevalence prevalence NN cord-010119-t1x9gknd 1747 2 among among IN cord-010119-t1x9gknd 1747 3 firsttime firsttime NN cord-010119-t1x9gknd 1747 4 donors donor NNS cord-010119-t1x9gknd 1747 5 was be VBD cord-010119-t1x9gknd 1747 6 , , , cord-010119-t1x9gknd 1747 7 as as IN cord-010119-t1x9gknd 1747 8 expected expect VBN cord-010119-t1x9gknd 1747 9 , , , cord-010119-t1x9gknd 1747 10 higher high JJR cord-010119-t1x9gknd 1747 11 than than IN cord-010119-t1x9gknd 1747 12 among among IN cord-010119-t1x9gknd 1747 13 donations donation NNS cord-010119-t1x9gknd 1747 14 from from IN cord-010119-t1x9gknd 1747 15 repeat repeat NN cord-010119-t1x9gknd 1747 16 donors donor NNS cord-010119-t1x9gknd 1747 17 with with IN cord-010119-t1x9gknd 1747 18 ratios ratio NNS cord-010119-t1x9gknd 1747 19 of of IN cord-010119-t1x9gknd 1747 20 23:1 23:1 CD cord-010119-t1x9gknd 1747 21 , , , cord-010119-t1x9gknd 1747 22 24:1 24:1 CD cord-010119-t1x9gknd 1747 23 and and CC cord-010119-t1x9gknd 1747 24 5.4:1 5.4:1 CD cord-010119-t1x9gknd 1747 25 for for IN cord-010119-t1x9gknd 1747 26 HBV HBV NNP cord-010119-t1x9gknd 1747 27 , , , cord-010119-t1x9gknd 1747 28 HCV HCV NNP cord-010119-t1x9gknd 1747 29 and and CC cord-010119-t1x9gknd 1747 30 HIV HIV NNP cord-010119-t1x9gknd 1747 31 . . . cord-010119-t1x9gknd 1748 1 Rates Rates NNP cord-010119-t1x9gknd 1748 2 ( ( -LRB- cord-010119-t1x9gknd 1748 3 pht pht NNP cord-010119-t1x9gknd 1748 4 ) ) -RRB- cord-010119-t1x9gknd 1748 5 among among IN cord-010119-t1x9gknd 1748 6 males male NNS cord-010119-t1x9gknd 1748 7 were be VBD cord-010119-t1x9gknd 1748 8 higher high JJR cord-010119-t1x9gknd 1748 9 than than IN cord-010119-t1x9gknd 1748 10 among among IN cord-010119-t1x9gknd 1748 11 females female NNS cord-010119-t1x9gknd 1748 12 for for IN cord-010119-t1x9gknd 1748 13 all all DT cord-010119-t1x9gknd 1748 14 markers marker NNS cord-010119-t1x9gknd 1748 15 ( ( -LRB- cord-010119-t1x9gknd 1748 16 HBV HBV NNP cord-010119-t1x9gknd 1748 17 8.3 8.3 CD cord-010119-t1x9gknd 1748 18 vs vs IN cord-010119-t1x9gknd 1748 19 4.2 4.2 CD cord-010119-t1x9gknd 1748 20 ; ; : cord-010119-t1x9gknd 1748 21 HCV HCV NNP cord-010119-t1x9gknd 1748 22 23.5 23.5 CD cord-010119-t1x9gknd 1748 23 vs vs IN cord-010119-t1x9gknd 1748 24 15.2 15.2 CD cord-010119-t1x9gknd 1748 25 ; ; : cord-010119-t1x9gknd 1748 26 HIV HIV NNP cord-010119-t1x9gknd 1748 27 3.9 3.9 CD cord-010119-t1x9gknd 1748 28 vs vs IN cord-010119-t1x9gknd 1748 29 1.0 1.0 CD cord-010119-t1x9gknd 1748 30 ) ) -RRB- cord-010119-t1x9gknd 1748 31 . . . cord-010119-t1x9gknd 1749 1 In in IN cord-010119-t1x9gknd 1749 2 general general JJ cord-010119-t1x9gknd 1749 3 , , , cord-010119-t1x9gknd 1749 4 higher high JJR cord-010119-t1x9gknd 1749 5 rates rate NNS cord-010119-t1x9gknd 1749 6 for for IN cord-010119-t1x9gknd 1749 7 all all DT cord-010119-t1x9gknd 1749 8 markers marker NNS cord-010119-t1x9gknd 1749 9 were be VBD cord-010119-t1x9gknd 1749 10 seen see VBN cord-010119-t1x9gknd 1749 11 among among IN cord-010119-t1x9gknd 1749 12 minority minority NN cord-010119-t1x9gknd 1749 13 donors donor NNS cord-010119-t1x9gknd 1749 14 , , , cord-010119-t1x9gknd 1749 15 those those DT cord-010119-t1x9gknd 1749 16 in in IN cord-010119-t1x9gknd 1749 17 the the DT cord-010119-t1x9gknd 1749 18 25 25 CD cord-010119-t1x9gknd 1749 19 - - HYPH cord-010119-t1x9gknd 1749 20 39-year 39-year JJ cord-010119-t1x9gknd 1749 21 age age NN cord-010119-t1x9gknd 1749 22 group group NN cord-010119-t1x9gknd 1749 23 ( ( -LRB- cord-010119-t1x9gknd 1749 24 also also RB cord-010119-t1x9gknd 1749 25 18 18 CD cord-010119-t1x9gknd 1749 26 - - SYM cord-010119-t1x9gknd 1749 27 24 24 CD cord-010119-t1x9gknd 1749 28 year year NN cord-010119-t1x9gknd 1749 29 for for IN cord-010119-t1x9gknd 1749 30 HIV HIV NNP cord-010119-t1x9gknd 1749 31 ) ) -RRB- cord-010119-t1x9gknd 1749 32 , , , cord-010119-t1x9gknd 1749 33 and and CC cord-010119-t1x9gknd 1749 34 those those DT cord-010119-t1x9gknd 1749 35 from from IN cord-010119-t1x9gknd 1749 36 the the DT cord-010119-t1x9gknd 1749 37 southeast southeast NN cord-010119-t1x9gknd 1749 38 ( ( -LRB- cord-010119-t1x9gknd 1749 39 and and CC cord-010119-t1x9gknd 1749 40 south south JJ cord-010119-t1x9gknd 1749 41 central central NN cord-010119-t1x9gknd 1749 42 for for IN cord-010119-t1x9gknd 1749 43 HIV HIV NNP cord-010119-t1x9gknd 1749 44 and and CC cord-010119-t1x9gknd 1749 45 HCV HCV NNP cord-010119-t1x9gknd 1749 46 , , , cord-010119-t1x9gknd 1749 47 and and CC cord-010119-t1x9gknd 1749 48 southwest southwest NN cord-010119-t1x9gknd 1749 49 for for IN cord-010119-t1x9gknd 1749 50 HBV HBV NNP cord-010119-t1x9gknd 1749 51 ) ) -RRB- cord-010119-t1x9gknd 1749 52 . . . cord-010119-t1x9gknd 1750 1 No no DT cord-010119-t1x9gknd 1750 2 trends trend NNS cord-010119-t1x9gknd 1750 3 were be VBD cord-010119-t1x9gknd 1750 4 noted note VBN cord-010119-t1x9gknd 1750 5 over over IN cord-010119-t1x9gknd 1750 6 time time NN cord-010119-t1x9gknd 1750 7 when when WRB cord-010119-t1x9gknd 1750 8 3-month 3-month CD cord-010119-t1x9gknd 1750 9 periods period NNS cord-010119-t1x9gknd 1750 10 were be VBD cord-010119-t1x9gknd 1750 11 compared compare VBN cord-010119-t1x9gknd 1750 12 . . . cord-010119-t1x9gknd 1751 1 Conclusion conclusion NN cord-010119-t1x9gknd 1751 2 : : : cord-010119-t1x9gknd 1752 1 Data datum NNS cord-010119-t1x9gknd 1752 2 from from IN cord-010119-t1x9gknd 1752 3 4 4 CD cord-010119-t1x9gknd 1752 4 major major JJ cord-010119-t1x9gknd 1752 5 US US NNP cord-010119-t1x9gknd 1752 6 blood blood NN cord-010119-t1x9gknd 1752 7 systems system NNS cord-010119-t1x9gknd 1752 8 were be VBD cord-010119-t1x9gknd 1752 9 successfully successfully RB cord-010119-t1x9gknd 1752 10 combined combine VBN cord-010119-t1x9gknd 1752 11 and and CC cord-010119-t1x9gknd 1752 12 are be VBP cord-010119-t1x9gknd 1752 13 a a DT cord-010119-t1x9gknd 1752 14 baseline baseline NN cord-010119-t1x9gknd 1752 15 for for IN cord-010119-t1x9gknd 1752 16 monitoring monitoring NN cord-010119-t1x9gknd 1752 17 purposes purpose NNS cord-010119-t1x9gknd 1752 18 . . . cord-010119-t1x9gknd 1753 1 Demographic demographic JJ cord-010119-t1x9gknd 1753 2 trends trend NNS cord-010119-t1x9gknd 1753 3 are be VBP cord-010119-t1x9gknd 1753 4 similar similar JJ cord-010119-t1x9gknd 1753 5 to to IN cord-010119-t1x9gknd 1753 6 those those DT cord-010119-t1x9gknd 1753 7 observed observe VBN cord-010119-t1x9gknd 1753 8 in in IN cord-010119-t1x9gknd 1753 9 other other JJ cord-010119-t1x9gknd 1753 10 donor donor NN cord-010119-t1x9gknd 1753 11 studies study NNS cord-010119-t1x9gknd 1753 12 and and CC cord-010119-t1x9gknd 1753 13 generally generally RB cord-010119-t1x9gknd 1753 14 agree agree VBP cord-010119-t1x9gknd 1753 15 with with IN cord-010119-t1x9gknd 1753 16 community community NN cord-010119-t1x9gknd 1753 17 trends trend NNS cord-010119-t1x9gknd 1753 18 . . . cord-010119-t1x9gknd 1754 1 Changes change NNS cord-010119-t1x9gknd 1754 2 in in IN cord-010119-t1x9gknd 1754 3 rates rate NNS cord-010119-t1x9gknd 1754 4 will will MD cord-010119-t1x9gknd 1754 5 require require VB cord-010119-t1x9gknd 1754 6 analyses analysis NNS cord-010119-t1x9gknd 1754 7 in in IN cord-010119-t1x9gknd 1754 8 the the DT cord-010119-t1x9gknd 1754 9 context context NN cord-010119-t1x9gknd 1754 10 of of IN cord-010119-t1x9gknd 1754 11 potential potential JJ cord-010119-t1x9gknd 1754 12 changes change NNS cord-010119-t1x9gknd 1754 13 in in IN cord-010119-t1x9gknd 1754 14 the the DT cord-010119-t1x9gknd 1754 15 demographic demographic JJ cord-010119-t1x9gknd 1754 16 structure structure NN cord-010119-t1x9gknd 1754 17 of of IN cord-010119-t1x9gknd 1754 18 the the DT cord-010119-t1x9gknd 1754 19 donor donor NN cord-010119-t1x9gknd 1754 20 population population NN cord-010119-t1x9gknd 1754 21 . . . cord-010119-t1x9gknd 1755 1 Screening screen VBG cord-010119-t1x9gknd 1755 2 Donated donate VBN cord-010119-t1x9gknd 1755 3 Blood blood NN cord-010119-t1x9gknd 1755 4 from from IN cord-010119-t1x9gknd 1755 5 Babesia Babesia NNP cord-010119-t1x9gknd 1755 6 Endemic Endemic NNP cord-010119-t1x9gknd 1755 7 Regions Regions NNPS cord-010119-t1x9gknd 1755 8 of of IN cord-010119-t1x9gknd 1755 9 the the DT cord-010119-t1x9gknd 1755 10 United United NNP cord-010119-t1x9gknd 1755 11 States States NNP cord-010119-t1x9gknd 1755 12 Using use VBG cord-010119-t1x9gknd 1755 13 a a DT cord-010119-t1x9gknd 1755 14 Transcription transcription NN cord-010119-t1x9gknd 1755 15 - - HYPH cord-010119-t1x9gknd 1755 16 Mediated mediate VBN cord-010119-t1x9gknd 1755 17 Amplification Amplification NNP cord-010119-t1x9gknd 1755 18 Assay Assay NNP cord-010119-t1x9gknd 1755 19 on on IN cord-010119-t1x9gknd 1755 20 a a DT cord-010119-t1x9gknd 1755 21 Fully fully RB cord-010119-t1x9gknd 1755 22 Automated automate VBN cord-010119-t1x9gknd 1755 23 System system NN cord-010119-t1x9gknd 1755 24 Vanessa Vanessa NNP cord-010119-t1x9gknd 1755 25 Bres Bres NNP cord-010119-t1x9gknd 1756 1 * * NFP cord-010119-t1x9gknd 1756 2 1 1 CD cord-010119-t1x9gknd 1756 3 , , , cord-010119-t1x9gknd 1756 4 Melanie Melanie NNP cord-010119-t1x9gknd 1756 5 C C NNP cord-010119-t1x9gknd 1756 6 Proctor Proctor NNP cord-010119-t1x9gknd 1756 7 2 2 CD cord-010119-t1x9gknd 1756 8 , , , cord-010119-t1x9gknd 1756 9 Deanna Deanna NNP cord-010119-t1x9gknd 1756 10 Self Self NNP cord-010119-t1x9gknd 1756 11 1 1 CD cord-010119-t1x9gknd 1756 12 , , , cord-010119-t1x9gknd 1756 13 Monique Monique NNP cord-010119-t1x9gknd 1756 14 Portugal Portugal NNP cord-010119-t1x9gknd 1756 15 1 1 CD cord-010119-t1x9gknd 1756 16 , , , cord-010119-t1x9gknd 1756 17 Adrian Adrian NNP cord-010119-t1x9gknd 1756 18 Gurrola Gurrola NNP cord-010119-t1x9gknd 1756 19 1 1 CD cord-010119-t1x9gknd 1756 20 , , , cord-010119-t1x9gknd 1756 21 Laura Laura NNP cord-010119-t1x9gknd 1756 22 Tonnetti Tonnetti NNP cord-010119-t1x9gknd 1756 23 2 2 CD cord-010119-t1x9gknd 1756 24 , , , cord-010119-t1x9gknd 1756 25 Sonia Sonia NNP cord-010119-t1x9gknd 1756 26 Bakkour Bakkour NNP cord-010119-t1x9gknd 1756 27 3 3 CD cord-010119-t1x9gknd 1756 28 , , , cord-010119-t1x9gknd 1756 29 Cheryl Cheryl NNP cord-010119-t1x9gknd 1756 30 Lobo Lobo NNP cord-010119-t1x9gknd 1756 31 4 4 CD cord-010119-t1x9gknd 1756 32 , , , cord-010119-t1x9gknd 1756 33 Michael Michael NNP cord-010119-t1x9gknd 1756 34 Paul Paul NNP cord-010119-t1x9gknd 1756 35 Busch Busch NNP cord-010119-t1x9gknd 1756 36 3 3 CD cord-010119-t1x9gknd 1756 37 , , , cord-010119-t1x9gknd 1756 38 Susan Susan NNP cord-010119-t1x9gknd 1756 39 L L NNP cord-010119-t1x9gknd 1756 40 Stramer Stramer NNP cord-010119-t1x9gknd 1756 41 2 2 CD cord-010119-t1x9gknd 1756 42 and and CC cord-010119-t1x9gknd 1756 43 Jeffrey Jeffrey NNP cord-010119-t1x9gknd 1756 44 M M NNP cord-010119-t1x9gknd 1756 45 Linnen Linnen NNP cord-010119-t1x9gknd 1756 46 1 1 CD cord-010119-t1x9gknd 1756 47 . . . cord-010119-t1x9gknd 1757 1 1 1 LS cord-010119-t1x9gknd 1758 1 Grifols Grifols NNP cord-010119-t1x9gknd 1758 2 Diagnostic Diagnostic NNP cord-010119-t1x9gknd 1758 3 Solutions Solutions NNPS cord-010119-t1x9gknd 1758 4 Inc. Inc. NNP cord-010119-t1x9gknd 1758 5 , , , cord-010119-t1x9gknd 1758 6 2 2 CD cord-010119-t1x9gknd 1758 7 American American NNP cord-010119-t1x9gknd 1758 8 Red Red NNP cord-010119-t1x9gknd 1758 9 Cross Cross NNP cord-010119-t1x9gknd 1758 10 , , , cord-010119-t1x9gknd 1758 11 3 3 CD cord-010119-t1x9gknd 1758 12 Blood Blood NNP cord-010119-t1x9gknd 1758 13 Systems Systems NNPS cord-010119-t1x9gknd 1758 14 Research Research NNP cord-010119-t1x9gknd 1758 15 Institute Institute NNP cord-010119-t1x9gknd 1758 16 , , , cord-010119-t1x9gknd 1758 17 4 4 CD cord-010119-t1x9gknd 1758 18 New New NNP cord-010119-t1x9gknd 1758 19 York York NNP cord-010119-t1x9gknd 1758 20 Blood Blood NNP cord-010119-t1x9gknd 1758 21 Center Center NNP cord-010119-t1x9gknd 1758 22 Background Background NNP cord-010119-t1x9gknd 1758 23 / / SYM cord-010119-t1x9gknd 1758 24 Case Case NNP cord-010119-t1x9gknd 1758 25 Studies Studies NNPS cord-010119-t1x9gknd 1758 26 : : : cord-010119-t1x9gknd 1759 1 The the DT cord-010119-t1x9gknd 1759 2 Procleix Procleix NNP cord-010119-t1x9gknd 1759 3 V v NN cord-010119-t1x9gknd 1759 4 R r NN cord-010119-t1x9gknd 1759 5 Babesia Babesia NNP cord-010119-t1x9gknd 1759 6 assay assay NN cord-010119-t1x9gknd 1759 7 on on IN cord-010119-t1x9gknd 1759 8 the the DT cord-010119-t1x9gknd 1759 9 Procleix Procleix NNP cord-010119-t1x9gknd 1759 10 Panther Panther NNP cord-010119-t1x9gknd 1759 11 V v NN cord-010119-t1x9gknd 1759 12 R r NN cord-010119-t1x9gknd 1759 13 system system NN cord-010119-t1x9gknd 1759 14 is be VBZ cord-010119-t1x9gknd 1759 15 a a DT cord-010119-t1x9gknd 1759 16 qualitative qualitative JJ cord-010119-t1x9gknd 1759 17 in in IN cord-010119-t1x9gknd 1759 18 vitro vitro FW cord-010119-t1x9gknd 1759 19 nucleic nucleic JJ cord-010119-t1x9gknd 1759 20 acid acid NN cord-010119-t1x9gknd 1759 21 test test NN cord-010119-t1x9gknd 1759 22 currently currently RB cord-010119-t1x9gknd 1759 23 under under IN cord-010119-t1x9gknd 1759 24 development development NN cord-010119-t1x9gknd 1759 25 . . . cord-010119-t1x9gknd 1760 1 The the DT cord-010119-t1x9gknd 1760 2 assay assay NN cord-010119-t1x9gknd 1760 3 , , , cord-010119-t1x9gknd 1760 4 which which WDT cord-010119-t1x9gknd 1760 5 is be VBZ cord-010119-t1x9gknd 1760 6 based base VBN cord-010119-t1x9gknd 1760 7 on on IN cord-010119-t1x9gknd 1760 8 Transcription transcription NN cord-010119-t1x9gknd 1760 9 - - HYPH cord-010119-t1x9gknd 1760 10 Mediated mediate VBN cord-010119-t1x9gknd 1760 11 Amplification amplification NN cord-010119-t1x9gknd 1760 12 ( ( -LRB- cord-010119-t1x9gknd 1760 13 TMA TMA NNP cord-010119-t1x9gknd 1760 14 ) ) -RRB- cord-010119-t1x9gknd 1760 15 , , , cord-010119-t1x9gknd 1760 16 detects detect VBZ cord-010119-t1x9gknd 1760 17 four four CD cord-010119-t1x9gknd 1760 18 clinically clinically RB cord-010119-t1x9gknd 1760 19 relevant relevant JJ cord-010119-t1x9gknd 1760 20 Babesia Babesia NNP cord-010119-t1x9gknd 1760 21 species specie NNS cord-010119-t1x9gknd 1760 22 ( ( -LRB- cord-010119-t1x9gknd 1760 23 B. B. NNP cord-010119-t1x9gknd 1760 24 microti microti NNP cord-010119-t1x9gknd 1760 25 , , , cord-010119-t1x9gknd 1760 26 B. B. NNP cord-010119-t1x9gknd 1760 27 divergens divergens NNP cord-010119-t1x9gknd 1760 28 , , , cord-010119-t1x9gknd 1760 29 B. B. NNP cord-010119-t1x9gknd 1760 30 duncani duncani NNP cord-010119-t1x9gknd 1760 31 , , , cord-010119-t1x9gknd 1760 32 and and CC cord-010119-t1x9gknd 1760 33 B. B. NNP cord-010119-t1x9gknd 1760 34 venatorum venatorum NNP cord-010119-t1x9gknd 1760 35 ) ) -RRB- cord-010119-t1x9gknd 1760 36 in in IN cord-010119-t1x9gknd 1760 37 human human JJ cord-010119-t1x9gknd 1760 38 whole whole JJ cord-010119-t1x9gknd 1760 39 blood blood NN cord-010119-t1x9gknd 1760 40 specimens specimen NNS cord-010119-t1x9gknd 1760 41 . . . cord-010119-t1x9gknd 1761 1 This this DT cord-010119-t1x9gknd 1761 2 test test NN cord-010119-t1x9gknd 1761 3 is be VBZ cord-010119-t1x9gknd 1761 4 intended intend VBN cord-010119-t1x9gknd 1761 5 to to TO cord-010119-t1x9gknd 1761 6 screen screen VB cord-010119-t1x9gknd 1761 7 blood blood NN cord-010119-t1x9gknd 1761 8 donations donation NNS cord-010119-t1x9gknd 1761 9 individually individually RB cord-010119-t1x9gknd 1761 10 and and CC cord-010119-t1x9gknd 1761 11 in in IN cord-010119-t1x9gknd 1761 12 pools pool NNS cord-010119-t1x9gknd 1761 13 of of IN cord-010119-t1x9gknd 1761 14 up up IN cord-010119-t1x9gknd 1761 15 to to TO cord-010119-t1x9gknd 1761 16 16 16 CD cord-010119-t1x9gknd 1761 17 donations donation NNS cord-010119-t1x9gknd 1761 18 . . . cord-010119-t1x9gknd 1762 1 Whole whole JJ cord-010119-t1x9gknd 1762 2 blood blood NN cord-010119-t1x9gknd 1762 3 samples sample NNS cord-010119-t1x9gknd 1762 4 are be VBP cord-010119-t1x9gknd 1762 5 lysed lyse VBN cord-010119-t1x9gknd 1762 6 and and CC cord-010119-t1x9gknd 1762 7 then then RB cord-010119-t1x9gknd 1762 8 pooled pool VBD cord-010119-t1x9gknd 1762 9 on on IN cord-010119-t1x9gknd 1762 10 the the DT cord-010119-t1x9gknd 1762 11 automated automate VBN cord-010119-t1x9gknd 1762 12 Procleix Procleix NNP cord-010119-t1x9gknd 1762 13 Xpress Xpress NNP cord-010119-t1x9gknd 1762 14 V v NN cord-010119-t1x9gknd 1762 15 R r NN cord-010119-t1x9gknd 1762 16 system system NN cord-010119-t1x9gknd 1762 17 prior prior RB cord-010119-t1x9gknd 1762 18 to to IN cord-010119-t1x9gknd 1762 19 testing testing NN cord-010119-t1x9gknd 1762 20 on on IN cord-010119-t1x9gknd 1762 21 the the DT cord-010119-t1x9gknd 1762 22 Procleix Procleix NNP cord-010119-t1x9gknd 1762 23 Panther Panther NNP cord-010119-t1x9gknd 1762 24 system system NN cord-010119-t1x9gknd 1762 25 . . . cord-010119-t1x9gknd 1763 1 These these DT cord-010119-t1x9gknd 1763 2 studies study NNS cord-010119-t1x9gknd 1763 3 evaluated evaluate VBD cord-010119-t1x9gknd 1763 4 the the DT cord-010119-t1x9gknd 1763 5 preliminary preliminary JJ cord-010119-t1x9gknd 1763 6 analytical analytical JJ cord-010119-t1x9gknd 1763 7 and and CC cord-010119-t1x9gknd 1763 8 clinical clinical JJ cord-010119-t1x9gknd 1763 9 performance performance NN cord-010119-t1x9gknd 1763 10 of of IN cord-010119-t1x9gknd 1763 11 the the DT cord-010119-t1x9gknd 1763 12 Procleix Procleix NNP cord-010119-t1x9gknd 1763 13 Babesia Babesia NNP cord-010119-t1x9gknd 1763 14 assay assay NN cord-010119-t1x9gknd 1763 15 on on IN cord-010119-t1x9gknd 1763 16 the the DT cord-010119-t1x9gknd 1763 17 Panther Panther NNP cord-010119-t1x9gknd 1763 18 system system NN cord-010119-t1x9gknd 1763 19 . . . cord-010119-t1x9gknd 1764 1 Study Study NNP cord-010119-t1x9gknd 1764 2 Design Design NNP cord-010119-t1x9gknd 1764 3 / / SYM cord-010119-t1x9gknd 1764 4 Method method NN cord-010119-t1x9gknd 1764 5 : : : cord-010119-t1x9gknd 1765 1 Analytical analytical JJ cord-010119-t1x9gknd 1765 2 sensitivity sensitivity NN cord-010119-t1x9gknd 1765 3 was be VBD cord-010119-t1x9gknd 1765 4 determined determine VBN cord-010119-t1x9gknd 1765 5 by by IN cord-010119-t1x9gknd 1765 6 diluting dilute VBG cord-010119-t1x9gknd 1765 7 in in IN cord-010119-t1x9gknd 1765 8 vitro vitro FW cord-010119-t1x9gknd 1765 9 synthesized synthesize VBN cord-010119-t1x9gknd 1765 10 RNA RNA NNP cord-010119-t1x9gknd 1765 11 transcripts transcript NNS cord-010119-t1x9gknd 1765 12 for for IN cord-010119-t1x9gknd 1765 13 the the DT cord-010119-t1x9gknd 1765 14 four four CD cord-010119-t1x9gknd 1765 15 Babesia Babesia NNP cord-010119-t1x9gknd 1765 16 species specie NNS cord-010119-t1x9gknd 1765 17 . . . cord-010119-t1x9gknd 1766 1 Fresh fresh JJ cord-010119-t1x9gknd 1766 2 B. B. NNP cord-010119-t1x9gknd 1766 3 microti microti NN cord-010119-t1x9gknd 1766 4 - - HYPH cord-010119-t1x9gknd 1766 5 infected infect VBN cord-010119-t1x9gknd 1766 6 hamster hamster NN cord-010119-t1x9gknd 1766 7 whole whole JJ cord-010119-t1x9gknd 1766 8 blood blood NN cord-010119-t1x9gknd 1766 9 , , , cord-010119-t1x9gknd 1766 10 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 1766 11 B. B. NNP cord-010119-t1x9gknd 1766 12 duncani duncani NNP cord-010119-t1x9gknd 1766 13 - - HYPH cord-010119-t1x9gknd 1766 14 infected infect VBN cord-010119-t1x9gknd 1766 15 hamster hamster NN cord-010119-t1x9gknd 1766 16 whole whole JJ cord-010119-t1x9gknd 1766 17 blood blood NN cord-010119-t1x9gknd 1766 18 and and CC cord-010119-t1x9gknd 1766 19 fresh fresh JJ cord-010119-t1x9gknd 1766 20 B. B. NNP cord-010119-t1x9gknd 1766 21 divergens divergens NNP cord-010119-t1x9gknd 1766 22 - - HYPH cord-010119-t1x9gknd 1766 23 infected infect VBN cord-010119-t1x9gknd 1766 24 human human JJ cord-010119-t1x9gknd 1766 25 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 1766 26 were be VBD cord-010119-t1x9gknd 1766 27 tested test VBN cord-010119-t1x9gknd 1766 28 to to TO cord-010119-t1x9gknd 1766 29 determine determine VB cord-010119-t1x9gknd 1766 30 the the DT cord-010119-t1x9gknd 1766 31 limit limit NN cord-010119-t1x9gknd 1766 32 of of IN cord-010119-t1x9gknd 1766 33 detection detection NN cord-010119-t1x9gknd 1766 34 ( ( -LRB- cord-010119-t1x9gknd 1766 35 LOD lod NN cord-010119-t1x9gknd 1766 36 ) ) -RRB- cord-010119-t1x9gknd 1766 37 of of IN cord-010119-t1x9gknd 1766 38 parasites parasite NNS cord-010119-t1x9gknd 1766 39 / / SYM cord-010119-t1x9gknd 1766 40 mL ml NN cord-010119-t1x9gknd 1766 41 ( ( -LRB- cord-010119-t1x9gknd 1766 42 p p NN cord-010119-t1x9gknd 1766 43 / / SYM cord-010119-t1x9gknd 1766 44 mL ml NN cord-010119-t1x9gknd 1766 45 ) ) -RRB- cord-010119-t1x9gknd 1766 46 by by IN cord-010119-t1x9gknd 1766 47 probit probit NN cord-010119-t1x9gknd 1766 48 analysis analysis NN cord-010119-t1x9gknd 1766 49 . . . cord-010119-t1x9gknd 1767 1 Clinical clinical JJ cord-010119-t1x9gknd 1767 2 sensitivity sensitivity NN cord-010119-t1x9gknd 1767 3 and and CC cord-010119-t1x9gknd 1767 4 specificity specificity NN cord-010119-t1x9gknd 1767 5 were be VBD cord-010119-t1x9gknd 1767 6 determined determine VBN cord-010119-t1x9gknd 1767 7 by by IN cord-010119-t1x9gknd 1767 8 screening screen VBG cord-010119-t1x9gknd 1767 9 32,274 32,274 CD cord-010119-t1x9gknd 1767 10 unlinked unlinked JJ cord-010119-t1x9gknd 1767 11 whole whole JJ cord-010119-t1x9gknd 1767 12 blood blood NN cord-010119-t1x9gknd 1767 13 donations donation NNS cord-010119-t1x9gknd 1767 14 collected collect VBN cord-010119-t1x9gknd 1767 15 from from IN cord-010119-t1x9gknd 1767 16 August August NNP cord-010119-t1x9gknd 1767 17 25 25 CD cord-010119-t1x9gknd 1767 18 th th XX cord-010119-t1x9gknd 1767 19 2016 2016 CD cord-010119-t1x9gknd 1767 20 to to IN cord-010119-t1x9gknd 1767 21 April April NNP cord-010119-t1x9gknd 1767 22 7 7 CD cord-010119-t1x9gknd 1767 23 th th CD cord-010119-t1x9gknd 1767 24 2017 2017 CD cord-010119-t1x9gknd 1767 25 in in IN cord-010119-t1x9gknd 1767 26 the the DT cord-010119-t1x9gknd 1767 27 northeastern northeastern JJ cord-010119-t1x9gknd 1767 28 United United NNP cord-010119-t1x9gknd 1767 29 States States NNP cord-010119-t1x9gknd 1767 30 . . . cord-010119-t1x9gknd 1768 1 Initial initial JJ cord-010119-t1x9gknd 1768 2 reactive reactive JJ cord-010119-t1x9gknd 1768 3 donations donation NNS cord-010119-t1x9gknd 1768 4 were be VBD cord-010119-t1x9gknd 1768 5 confirmed confirm VBN cord-010119-t1x9gknd 1768 6 by by IN cord-010119-t1x9gknd 1768 7 repeat repeat NN cord-010119-t1x9gknd 1768 8 testing testing NN cord-010119-t1x9gknd 1768 9 , , , cord-010119-t1x9gknd 1768 10 PCR PCR NNP cord-010119-t1x9gknd 1768 11 , , , cord-010119-t1x9gknd 1768 12 and/or and/or CC cord-010119-t1x9gknd 1768 13 IgG igg NN cord-010119-t1x9gknd 1768 14 immunofluorescence immunofluorescence NN cord-010119-t1x9gknd 1768 15 assay assay NN cord-010119-t1x9gknd 1768 16 ( ( -LRB- cord-010119-t1x9gknd 1768 17 IFA IFA NNP cord-010119-t1x9gknd 1768 18 ) ) -RRB- cord-010119-t1x9gknd 1768 19 . . . cord-010119-t1x9gknd 1769 1 Reactive reactive JJ cord-010119-t1x9gknd 1769 2 individual individual JJ cord-010119-t1x9gknd 1769 3 donor donor NN cord-010119-t1x9gknd 1769 4 lysates lysate NNS cord-010119-t1x9gknd 1769 5 were be VBD cord-010119-t1x9gknd 1769 6 tested test VBN cord-010119-t1x9gknd 1769 7 in in IN cord-010119-t1x9gknd 1769 8 pools pool NNS cord-010119-t1x9gknd 1769 9 of of IN cord-010119-t1x9gknd 1769 10 16 16 CD cord-010119-t1x9gknd 1769 11 . . . cord-010119-t1x9gknd 1770 1 Results/ Results/ . cord-010119-t1x9gknd 1771 1 Finding finding NN cord-010119-t1x9gknd 1771 2 : : : cord-010119-t1x9gknd 1772 1 The the DT cord-010119-t1x9gknd 1772 2 Procleix Procleix NNP cord-010119-t1x9gknd 1772 3 Babesia Babesia NNP cord-010119-t1x9gknd 1772 4 assay assay NN cord-010119-t1x9gknd 1772 5 detected detect VBD cord-010119-t1x9gknd 1772 6 all all DT cord-010119-t1x9gknd 1772 7 four four CD cord-010119-t1x9gknd 1772 8 Babesia Babesia NNP cord-010119-t1x9gknd 1772 9 species specie NNS cord-010119-t1x9gknd 1772 10 with with IN cord-010119-t1x9gknd 1772 11 a a DT cord-010119-t1x9gknd 1772 12 95 95 CD cord-010119-t1x9gknd 1772 13 % % NN cord-010119-t1x9gknd 1772 14 LOD lod NN cord-010119-t1x9gknd 1772 15 ranging range VBG cord-010119-t1x9gknd 1772 16 from from IN cord-010119-t1x9gknd 1772 17 7.10 7.10 CD cord-010119-t1x9gknd 1772 18 - - SYM cord-010119-t1x9gknd 1772 19 13.51 13.51 CD cord-010119-t1x9gknd 1772 20 copies/ copies/ CD cord-010119-t1x9gknd 1773 1 mL. mL. NNP cord-010119-t1x9gknd 1774 1 The the DT cord-010119-t1x9gknd 1774 2 preliminary preliminary JJ cord-010119-t1x9gknd 1774 3 95 95 CD cord-010119-t1x9gknd 1774 4 % % NN cord-010119-t1x9gknd 1774 5 LOD lod NN cord-010119-t1x9gknd 1774 6 in in IN cord-010119-t1x9gknd 1774 7 parasites parasite NNS cord-010119-t1x9gknd 1774 8 / / SYM cord-010119-t1x9gknd 1774 9 mL ml NN cord-010119-t1x9gknd 1774 10 ranged range VBD cord-010119-t1x9gknd 1774 11 from from IN cord-010119-t1x9gknd 1774 12 0.64 0.64 CD cord-010119-t1x9gknd 1774 13 - - HYPH cord-010119-t1x9gknd 1774 14 3.61 3.61 CD cord-010119-t1x9gknd 1774 15 p p NN cord-010119-t1x9gknd 1774 16 / / SYM cord-010119-t1x9gknd 1774 17 mL ml NN cord-010119-t1x9gknd 1774 18 for for IN cord-010119-t1x9gknd 1774 19 B. B. NNP cord-010119-t1x9gknd 1774 20 microti microti NNP cord-010119-t1x9gknd 1774 21 ( ( -LRB- cord-010119-t1x9gknd 1774 22 n59 n59 NN cord-010119-t1x9gknd 1774 23 ) ) -RRB- cord-010119-t1x9gknd 1774 24 , , , cord-010119-t1x9gknd 1774 25 from from IN cord-010119-t1x9gknd 1774 26 0.92 0.92 CD cord-010119-t1x9gknd 1774 27 - - HYPH cord-010119-t1x9gknd 1774 28 1.52 1.52 CD cord-010119-t1x9gknd 1774 29 p p NN cord-010119-t1x9gknd 1774 30 / / SYM cord-010119-t1x9gknd 1774 31 mL ml NN cord-010119-t1x9gknd 1774 32 for for IN cord-010119-t1x9gknd 1774 33 B. B. NNP cord-010119-t1x9gknd 1774 34 duncani duncani NNP cord-010119-t1x9gknd 1774 35 ( ( -LRB- cord-010119-t1x9gknd 1774 36 n52 n52 NNP cord-010119-t1x9gknd 1774 37 ) ) -RRB- cord-010119-t1x9gknd 1774 38 , , , cord-010119-t1x9gknd 1774 39 and and CC cord-010119-t1x9gknd 1774 40 from from IN cord-010119-t1x9gknd 1774 41 0.62 0.62 CD cord-010119-t1x9gknd 1774 42 - - SYM cord-010119-t1x9gknd 1774 43 4.95 4.95 CD cord-010119-t1x9gknd 1774 44 p p NN cord-010119-t1x9gknd 1774 45 / / SYM cord-010119-t1x9gknd 1774 46 mL ml NN cord-010119-t1x9gknd 1774 47 for for IN cord-010119-t1x9gknd 1774 48 B. B. NNP cord-010119-t1x9gknd 1774 49 divergens divergens NNP cord-010119-t1x9gknd 1774 50 ( ( -LRB- cord-010119-t1x9gknd 1774 51 n52 n52 NNP cord-010119-t1x9gknd 1774 52 ) ) -RRB- cord-010119-t1x9gknd 1774 53 . . . cord-010119-t1x9gknd 1775 1 Of of IN cord-010119-t1x9gknd 1775 2 the the DT cord-010119-t1x9gknd 1775 3 32,274 32,274 CD cord-010119-t1x9gknd 1775 4 donations donation NNS cord-010119-t1x9gknd 1775 5 screened screen VBN cord-010119-t1x9gknd 1775 6 , , , cord-010119-t1x9gknd 1775 7 17 17 CD cord-010119-t1x9gknd 1775 8 initial initial JJ cord-010119-t1x9gknd 1775 9 reactive reactive JJ cord-010119-t1x9gknd 1775 10 and and CC cord-010119-t1x9gknd 1775 11 14 14 CD cord-010119-t1x9gknd 1775 12 confirmed confirm VBD cord-010119-t1x9gknd 1775 13 positive positive JJ cord-010119-t1x9gknd 1775 14 donations donation NNS cord-010119-t1x9gknd 1775 15 were be VBD cord-010119-t1x9gknd 1775 16 identified identify VBN cord-010119-t1x9gknd 1775 17 for for IN cord-010119-t1x9gknd 1775 18 specificity specificity NN cord-010119-t1x9gknd 1775 19 of of IN cord-010119-t1x9gknd 1775 20 99.991 99.991 CD cord-010119-t1x9gknd 1775 21 % % NN cord-010119-t1x9gknd 1775 22 ( ( -LRB- cord-010119-t1x9gknd 1775 23 95%CI 95%ci CD cord-010119-t1x9gknd 1775 24 : : : cord-010119-t1x9gknd 1775 25 99.972 99.972 CD cord-010119-t1x9gknd 1775 26 - - HYPH cord-010119-t1x9gknd 1775 27 99.997 99.997 CD cord-010119-t1x9gknd 1775 28 % % NN cord-010119-t1x9gknd 1775 29 ) ) -RRB- cord-010119-t1x9gknd 1775 30 . . . cord-010119-t1x9gknd 1776 1 Of of IN cord-010119-t1x9gknd 1776 2 the the DT cord-010119-t1x9gknd 1776 3 confirmed confirm VBN cord-010119-t1x9gknd 1776 4 positive positive JJ cord-010119-t1x9gknd 1776 5 specimens specimen NNS cord-010119-t1x9gknd 1776 6 , , , cord-010119-t1x9gknd 1776 7 8 8 CD cord-010119-t1x9gknd 1776 8 were be VBD cord-010119-t1x9gknd 1776 9 reactive reactive JJ cord-010119-t1x9gknd 1776 10 by by IN cord-010119-t1x9gknd 1776 11 both both CC cord-010119-t1x9gknd 1776 12 IFA IFA NNP cord-010119-t1x9gknd 1776 13 and and CC cord-010119-t1x9gknd 1776 14 PCR PCR NNP cord-010119-t1x9gknd 1776 15 , , , cord-010119-t1x9gknd 1776 16 5 5 CD cord-010119-t1x9gknd 1776 17 by by IN cord-010119-t1x9gknd 1776 18 IFA IFA NNP cord-010119-t1x9gknd 1776 19 only only RB cord-010119-t1x9gknd 1776 20 and and CC cord-010119-t1x9gknd 1776 21 1 1 CD cord-010119-t1x9gknd 1776 22 by by IN cord-010119-t1x9gknd 1776 23 PCR PCR NNP cord-010119-t1x9gknd 1776 24 only only RB cord-010119-t1x9gknd 1776 25 . . . cord-010119-t1x9gknd 1777 1 All all DT cord-010119-t1x9gknd 1777 2 confirmed confirm VBD cord-010119-t1x9gknd 1777 3 positive positive JJ cord-010119-t1x9gknd 1777 4 samples sample NNS cord-010119-t1x9gknd 1777 5 were be VBD cord-010119-t1x9gknd 1777 6 reactive reactive JJ cord-010119-t1x9gknd 1777 7 in in IN cord-010119-t1x9gknd 1777 8 lysate lysate NN cord-010119-t1x9gknd 1777 9 pools pool NNS cord-010119-t1x9gknd 1777 10 of of IN cord-010119-t1x9gknd 1777 11 16 16 CD cord-010119-t1x9gknd 1777 12 . . . cord-010119-t1x9gknd 1778 1 Donors donor NNS cord-010119-t1x9gknd 1778 2 of of IN cord-010119-t1x9gknd 1778 3 reactive reactive JJ cord-010119-t1x9gknd 1778 4 donations donation NNS cord-010119-t1x9gknd 1778 5 resided reside VBN cord-010119-t1x9gknd 1778 6 in in IN cord-010119-t1x9gknd 1778 7 CT CT NNP cord-010119-t1x9gknd 1778 8 ( ( -LRB- cord-010119-t1x9gknd 1778 9 11 11 CD cord-010119-t1x9gknd 1778 10 ) ) -RRB- cord-010119-t1x9gknd 1778 11 , , , cord-010119-t1x9gknd 1778 12 NJ NJ NNP cord-010119-t1x9gknd 1778 13 ( ( -LRB- cord-010119-t1x9gknd 1778 14 1 1 CD cord-010119-t1x9gknd 1778 15 ) ) -RRB- cord-010119-t1x9gknd 1778 16 , , , cord-010119-t1x9gknd 1778 17 NH NH NNP cord-010119-t1x9gknd 1778 18 ( ( -LRB- cord-010119-t1x9gknd 1778 19 1 1 CD cord-010119-t1x9gknd 1778 20 ) ) -RRB- cord-010119-t1x9gknd 1778 21 and and CC cord-010119-t1x9gknd 1778 22 ME ME NNP cord-010119-t1x9gknd 1778 23 ( ( -LRB- cord-010119-t1x9gknd 1778 24 1 1 CD cord-010119-t1x9gknd 1778 25 ) ) -RRB- cord-010119-t1x9gknd 1778 26 for for IN cord-010119-t1x9gknd 1778 27 an an DT cord-010119-t1x9gknd 1778 28 overall overall JJ cord-010119-t1x9gknd 1778 29 incidence incidence NN cord-010119-t1x9gknd 1778 30 of of IN cord-010119-t1x9gknd 1778 31 1:2,305 1:2,305 CD cord-010119-t1x9gknd 1778 32 , , , cord-010119-t1x9gknd 1778 33 and and CC cord-010119-t1x9gknd 1778 34 1:1,433 1:1,433 CD cord-010119-t1x9gknd 1778 35 in in IN cord-010119-t1x9gknd 1778 36 CT CT NNP cord-010119-t1x9gknd 1778 37 . . . cord-010119-t1x9gknd 1779 1 Conclusion conclusion NN cord-010119-t1x9gknd 1779 2 : : : cord-010119-t1x9gknd 1780 1 The the DT cord-010119-t1x9gknd 1780 2 Procleix Procleix NNP cord-010119-t1x9gknd 1780 3 Babesia Babesia NNP cord-010119-t1x9gknd 1780 4 assay assay NN cord-010119-t1x9gknd 1780 5 on on IN cord-010119-t1x9gknd 1780 6 the the DT cord-010119-t1x9gknd 1780 7 Procleix Procleix NNP cord-010119-t1x9gknd 1780 8 Panther Panther NNP cord-010119-t1x9gknd 1780 9 system system NN cord-010119-t1x9gknd 1780 10 demonstrated demonstrate VBD cord-010119-t1x9gknd 1780 11 high high JJ cord-010119-t1x9gknd 1780 12 clinical clinical JJ cord-010119-t1x9gknd 1780 13 specificity specificity NN cord-010119-t1x9gknd 1780 14 and and CC cord-010119-t1x9gknd 1780 15 sensitivity sensitivity NN cord-010119-t1x9gknd 1780 16 and and CC cord-010119-t1x9gknd 1780 17 detected detect VBD cord-010119-t1x9gknd 1780 18 all all DT cord-010119-t1x9gknd 1780 19 four four CD cord-010119-t1x9gknd 1780 20 Babesia Babesia NNP cord-010119-t1x9gknd 1780 21 species specie NNS cord-010119-t1x9gknd 1780 22 with with IN cord-010119-t1x9gknd 1780 23 similar similar JJ cord-010119-t1x9gknd 1780 24 sensitivity sensitivity NN cord-010119-t1x9gknd 1780 25 . . . cord-010119-t1x9gknd 1781 1 All all DT cord-010119-t1x9gknd 1781 2 confirmed confirm VBD cord-010119-t1x9gknd 1781 3 positive positive JJ cord-010119-t1x9gknd 1781 4 donations donation NNS cord-010119-t1x9gknd 1781 5 were be VBD cord-010119-t1x9gknd 1781 6 also also RB cord-010119-t1x9gknd 1781 7 detected detect VBN cord-010119-t1x9gknd 1781 8 in in IN cord-010119-t1x9gknd 1781 9 pools pool NNS cord-010119-t1x9gknd 1781 10 of of IN cord-010119-t1x9gknd 1781 11 16 16 CD cord-010119-t1x9gknd 1781 12 thus thus RB cord-010119-t1x9gknd 1781 13 demonstrating demonstrate VBG cord-010119-t1x9gknd 1781 14 the the DT cord-010119-t1x9gknd 1781 15 effectiveness effectiveness NN cord-010119-t1x9gknd 1781 16 of of IN cord-010119-t1x9gknd 1781 17 pooled pool VBN cord-010119-t1x9gknd 1781 18 lysate lysate NN cord-010119-t1x9gknd 1781 19 screening screening NN cord-010119-t1x9gknd 1781 20 . . . cord-010119-t1x9gknd 1782 1 Conclusion conclusion NN cord-010119-t1x9gknd 1782 2 : : : cord-010119-t1x9gknd 1783 1 Use use NN cord-010119-t1x9gknd 1783 2 of of IN cord-010119-t1x9gknd 1783 3 the the DT cord-010119-t1x9gknd 1783 4 LAg LAg NNS cord-010119-t1x9gknd 1783 5 avidity avidity NN cord-010119-t1x9gknd 1783 6 assay assay NN cord-010119-t1x9gknd 1783 7 shows show VBZ cord-010119-t1x9gknd 1783 8 that that IN cord-010119-t1x9gknd 1783 9 in in IN cord-010119-t1x9gknd 1783 10 both both DT cord-010119-t1x9gknd 1783 11 first first JJ cord-010119-t1x9gknd 1783 12 - - HYPH cord-010119-t1x9gknd 1783 13 time time NN cord-010119-t1x9gknd 1783 14 and and CC cord-010119-t1x9gknd 1783 15 repeat repeat VB cord-010119-t1x9gknd 1783 16 HIV HIV NNP cord-010119-t1x9gknd 1783 17 - - HYPH cord-010119-t1x9gknd 1783 18 positive positive JJ cord-010119-t1x9gknd 1783 19 US US NNP cord-010119-t1x9gknd 1783 20 blood blood NN cord-010119-t1x9gknd 1783 21 donors donor NNS cord-010119-t1x9gknd 1783 22 , , , cord-010119-t1x9gknd 1783 23 newly newly RB cord-010119-t1x9gknd 1783 24 - - HYPH cord-010119-t1x9gknd 1783 25 acquired acquire VBN cord-010119-t1x9gknd 1783 26 ( ( -LRB- cord-010119-t1x9gknd 1783 27 i.e. i.e. FW cord-010119-t1x9gknd 1783 28 , , , cord-010119-t1x9gknd 1783 29 incident incident NN cord-010119-t1x9gknd 1783 30 ) ) -RRB- cord-010119-t1x9gknd 1784 1 HIV HIV NNP cord-010119-t1x9gknd 1784 2 infections infection NNS cord-010119-t1x9gknd 1784 3 are be VBP cord-010119-t1x9gknd 1784 4 more more RBR cord-010119-t1x9gknd 1784 5 frequent frequent JJ cord-010119-t1x9gknd 1784 6 in in IN cord-010119-t1x9gknd 1784 7 younger young JJR cord-010119-t1x9gknd 1784 8 donors donor NNS cord-010119-t1x9gknd 1784 9 . . . cord-010119-t1x9gknd 1785 1 The the DT cord-010119-t1x9gknd 1785 2 use use NN cord-010119-t1x9gknd 1785 3 of of IN cord-010119-t1x9gknd 1785 4 this this DT cord-010119-t1x9gknd 1785 5 approach approach NN cord-010119-t1x9gknd 1785 6 provides provide VBZ cord-010119-t1x9gknd 1785 7 an an DT cord-010119-t1x9gknd 1785 8 additional additional JJ cord-010119-t1x9gknd 1785 9 monitoring monitoring NN cord-010119-t1x9gknd 1785 10 tool tool NN cord-010119-t1x9gknd 1785 11 to to TO cord-010119-t1x9gknd 1785 12 assess assess VB cord-010119-t1x9gknd 1785 13 changes change NNS cord-010119-t1x9gknd 1785 14 in in IN cord-010119-t1x9gknd 1785 15 characteristics characteristic NNS cord-010119-t1x9gknd 1785 16 of of IN cord-010119-t1x9gknd 1785 17 donors donor NNS cord-010119-t1x9gknd 1785 18 whose whose WP$ cord-010119-t1x9gknd 1785 19 risk risk NN cord-010119-t1x9gknd 1785 20 exposure exposure NN cord-010119-t1x9gknd 1785 21 was be VBD cord-010119-t1x9gknd 1785 22 proximate proximate JJ cord-010119-t1x9gknd 1785 23 to to IN cord-010119-t1x9gknd 1785 24 the the DT cord-010119-t1x9gknd 1785 25 date date NN cord-010119-t1x9gknd 1785 26 of of IN cord-010119-t1x9gknd 1785 27 donation donation NN cord-010119-t1x9gknd 1785 28 and and CC cord-010119-t1x9gknd 1785 29 will will MD cord-010119-t1x9gknd 1785 30 also also RB cord-010119-t1x9gknd 1785 31 complement complement VB cord-010119-t1x9gknd 1785 32 traditional traditional JJ cord-010119-t1x9gknd 1785 33 incidence incidence NN cord-010119-t1x9gknd 1785 34 methods method NNS cord-010119-t1x9gknd 1785 35 by by IN cord-010119-t1x9gknd 1785 36 allowing allow VBG cord-010119-t1x9gknd 1785 37 derivation derivation NN cord-010119-t1x9gknd 1785 38 of of IN cord-010119-t1x9gknd 1785 39 incidence incidence NN cord-010119-t1x9gknd 1785 40 by by IN cord-010119-t1x9gknd 1785 41 donor donor NN cord-010119-t1x9gknd 1785 42 type type NN cord-010119-t1x9gknd 1785 43 . . . cord-010119-t1x9gknd 1786 1 Epidemiology Epidemiology NNP cord-010119-t1x9gknd 1786 2 of of IN cord-010119-t1x9gknd 1786 3 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 1786 4 B B NNP cord-010119-t1x9gknd 1786 5 Virus Virus NNP cord-010119-t1x9gknd 1786 6 , , , cord-010119-t1x9gknd 1786 7 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 1786 8 C C NNP cord-010119-t1x9gknd 1786 9 Virus Virus NNP cord-010119-t1x9gknd 1786 10 and and CC cord-010119-t1x9gknd 1786 11 Human Human NNP cord-010119-t1x9gknd 1786 12 Immunodeficiency Immunodeficiency NNP cord-010119-t1x9gknd 1786 13 Virus Virus NNP cord-010119-t1x9gknd 1786 14 in in IN cord-010119-t1x9gknd 1786 15 United United NNP cord-010119-t1x9gknd 1786 16 States States NNP cord-010119-t1x9gknd 1786 17 Blood Blood NNP cord-010119-t1x9gknd 1786 18 Donors donor NNS cord-010119-t1x9gknd 1787 1 Lauren Lauren NNP cord-010119-t1x9gknd 1787 2 A a DT cord-010119-t1x9gknd 1787 3 Crowder Crowder NNP cord-010119-t1x9gknd 1787 4 * * NFP cord-010119-t1x9gknd 1787 5 1 1 CD cord-010119-t1x9gknd 1787 6 , , , cord-010119-t1x9gknd 1787 7 Whitney Whitney NNP cord-010119-t1x9gknd 1787 8 R R NNP cord-010119-t1x9gknd 1787 9 Steele Steele NNP cord-010119-t1x9gknd 1787 10 1 1 CD cord-010119-t1x9gknd 1787 11 , , , cord-010119-t1x9gknd 1787 12 Ed Ed NNP cord-010119-t1x9gknd 1787 13 P P NNP cord-010119-t1x9gknd 1787 14 Notari Notari NNP cord-010119-t1x9gknd 1787 15 1 1 CD cord-010119-t1x9gknd 1787 16 , , , cord-010119-t1x9gknd 1787 17 James James NNP cord-010119-t1x9gknd 1787 18 Haynes Haynes NNP cord-010119-t1x9gknd 1787 19 1 1 CD cord-010119-t1x9gknd 1787 20 , , , cord-010119-t1x9gknd 1787 21 Roger Roger NNP cord-010119-t1x9gknd 1787 22 Y Y NNP cord-010119-t1x9gknd 1787 23 Dodd Dodd NNP cord-010119-t1x9gknd 1787 24 2 2 CD cord-010119-t1x9gknd 1787 25 and and CC cord-010119-t1x9gknd 1787 26 Susan Susan NNP cord-010119-t1x9gknd 1787 27 L L NNP cord-010119-t1x9gknd 1787 28 Stramer Stramer NNP cord-010119-t1x9gknd 1787 29 1 1 CD cord-010119-t1x9gknd 1787 30 . . . cord-010119-t1x9gknd 1787 31 1 1 CD cord-010119-t1x9gknd 1787 32 American American NNP cord-010119-t1x9gknd 1787 33 Red Red NNP cord-010119-t1x9gknd 1787 34 Cross Cross NNP cord-010119-t1x9gknd 1787 35 , , , cord-010119-t1x9gknd 1787 36 2 2 CD cord-010119-t1x9gknd 1787 37 American American NNP cord-010119-t1x9gknd 1787 38 Red Red NNP cord-010119-t1x9gknd 1787 39 Cross Cross NNP cord-010119-t1x9gknd 1787 40 ( ( -LRB- cord-010119-t1x9gknd 1787 41 retired retire VBN cord-010119-t1x9gknd 1787 42 ) ) -RRB- cord-010119-t1x9gknd 1788 1 Background Background NNP cord-010119-t1x9gknd 1788 2 / / SYM cord-010119-t1x9gknd 1788 3 Case Case NNP cord-010119-t1x9gknd 1788 4 Studies Studies NNPS cord-010119-t1x9gknd 1788 5 : : : cord-010119-t1x9gknd 1789 1 From from IN cord-010119-t1x9gknd 1789 2 2004 2004 CD cord-010119-t1x9gknd 1789 3 -2012 -2012 NN cord-010119-t1x9gknd 1789 4 , , , cord-010119-t1x9gknd 1789 5 the the DT cord-010119-t1x9gknd 1789 6 prevalence prevalence NN cord-010119-t1x9gknd 1789 7 of of IN cord-010119-t1x9gknd 1789 8 HBV HBV NNP cord-010119-t1x9gknd 1789 9 and and CC cord-010119-t1x9gknd 1789 10 HCV HCV NNP cord-010119-t1x9gknd 1789 11 in in IN cord-010119-t1x9gknd 1789 12 US US NNP cord-010119-t1x9gknd 1789 13 blood blood NN cord-010119-t1x9gknd 1789 14 donors donor NNS cord-010119-t1x9gknd 1789 15 decreased decrease VBD cord-010119-t1x9gknd 1789 16 , , , cord-010119-t1x9gknd 1789 17 while while IN cord-010119-t1x9gknd 1789 18 HIV HIV NNP cord-010119-t1x9gknd 1789 19 rates rate NNS cord-010119-t1x9gknd 1789 20 remained remain VBD cord-010119-t1x9gknd 1789 21 constant constant JJ cord-010119-t1x9gknd 1789 22 . . . cord-010119-t1x9gknd 1790 1 However however RB cord-010119-t1x9gknd 1790 2 , , , cord-010119-t1x9gknd 1790 3 incidence incidence NN cord-010119-t1x9gknd 1790 4 has have VBZ cord-010119-t1x9gknd 1790 5 not not RB cord-010119-t1x9gknd 1790 6 been be VBN cord-010119-t1x9gknd 1790 7 recently recently RB cord-010119-t1x9gknd 1790 8 calculated calculate VBN cord-010119-t1x9gknd 1790 9 . . . cord-010119-t1x9gknd 1791 1 Here here RB cord-010119-t1x9gknd 1791 2 we -PRON- PRP cord-010119-t1x9gknd 1791 3 report report VBP cord-010119-t1x9gknd 1791 4 the the DT cord-010119-t1x9gknd 1791 5 prevalence prevalence NN cord-010119-t1x9gknd 1791 6 , , , cord-010119-t1x9gknd 1791 7 incidence incidence NN cord-010119-t1x9gknd 1791 8 and and CC cord-010119-t1x9gknd 1791 9 residual residual JJ cord-010119-t1x9gknd 1791 10 risk risk NN cord-010119-t1x9gknd 1791 11 ( ( -LRB- cord-010119-t1x9gknd 1791 12 RR RR NNP cord-010119-t1x9gknd 1791 13 ) ) -RRB- cord-010119-t1x9gknd 1791 14 of of IN cord-010119-t1x9gknd 1791 15 HBV HBV NNP cord-010119-t1x9gknd 1791 16 , , , cord-010119-t1x9gknd 1791 17 HCV HCV NNP cord-010119-t1x9gknd 1791 18 , , , cord-010119-t1x9gknd 1791 19 and and CC cord-010119-t1x9gknd 1791 20 HIV HIV NNP cord-010119-t1x9gknd 1791 21 in in IN cord-010119-t1x9gknd 1791 22 a a DT cord-010119-t1x9gknd 1791 23 large large JJ cord-010119-t1x9gknd 1791 24 US US NNP cord-010119-t1x9gknd 1791 25 blood blood NN cord-010119-t1x9gknd 1791 26 system system NN cord-010119-t1x9gknd 1791 27 from from IN cord-010119-t1x9gknd 1791 28 2008 2008 CD cord-010119-t1x9gknd 1791 29 - - SYM cord-010119-t1x9gknd 1791 30 2015 2015 CD cord-010119-t1x9gknd 1791 31 . . . cord-010119-t1x9gknd 1792 1 Study Study NNP cord-010119-t1x9gknd 1792 2 Design Design NNP cord-010119-t1x9gknd 1792 3 / / SYM cord-010119-t1x9gknd 1792 4 Methods method NNS cord-010119-t1x9gknd 1792 5 : : : cord-010119-t1x9gknd 1792 6 Prevalence prevalence NN cord-010119-t1x9gknd 1792 7 was be VBD cord-010119-t1x9gknd 1792 8 calculated calculate VBN cord-010119-t1x9gknd 1792 9 in in IN cord-010119-t1x9gknd 1792 10 2-year 2-year CD cord-010119-t1x9gknd 1792 11 intervals interval NNS cord-010119-t1x9gknd 1792 12 . . . cord-010119-t1x9gknd 1793 1 Incidence incidence NN cord-010119-t1x9gknd 1793 2 was be VBD cord-010119-t1x9gknd 1793 3 measured measure VBN cord-010119-t1x9gknd 1793 4 as as IN cord-010119-t1x9gknd 1793 5 the the DT cord-010119-t1x9gknd 1793 6 number number NN cord-010119-t1x9gknd 1793 7 of of IN cord-010119-t1x9gknd 1793 8 positives positive NNS cord-010119-t1x9gknd 1793 9 among among IN cord-010119-t1x9gknd 1793 10 repeat repeat NN cord-010119-t1x9gknd 1793 11 donors donor NNS cord-010119-t1x9gknd 1793 12 divided divide VBN cord-010119-t1x9gknd 1793 13 by by IN cord-010119-t1x9gknd 1793 14 the the DT cord-010119-t1x9gknd 1793 15 total total JJ cord-010119-t1x9gknd 1793 16 time time NN cord-010119-t1x9gknd 1793 17 at at IN cord-010119-t1x9gknd 1793 18 risk risk NN cord-010119-t1x9gknd 1793 19 , , , cord-010119-t1x9gknd 1793 20 in in IN cord-010119-t1x9gknd 1793 21 person person NN cord-010119-t1x9gknd 1793 22 - - HYPH cord-010119-t1x9gknd 1793 23 years year NNS cord-010119-t1x9gknd 1793 24 ( ( -LRB- cord-010119-t1x9gknd 1793 25 PY py NN cord-010119-t1x9gknd 1793 26 ) ) -RRB- cord-010119-t1x9gknd 1793 27 . . . cord-010119-t1x9gknd 1794 1 RR RR NNP cord-010119-t1x9gknd 1794 2 was be VBD cord-010119-t1x9gknd 1794 3 calculated calculate VBN cord-010119-t1x9gknd 1794 4 using use VBG cord-010119-t1x9gknd 1794 5 the the DT cord-010119-t1x9gknd 1794 6 window window NN cord-010119-t1x9gknd 1794 7 periods period NNS cord-010119-t1x9gknd 1794 8 of of IN cord-010119-t1x9gknd 1794 9 18.5 18.5 CD cord-010119-t1x9gknd 1794 10 , , , cord-010119-t1x9gknd 1794 11 7.4 7.4 CD cord-010119-t1x9gknd 1794 12 and and CC cord-010119-t1x9gknd 1794 13 9.1 9.1 CD cord-010119-t1x9gknd 1794 14 days day NNS cord-010119-t1x9gknd 1794 15 for for IN cord-010119-t1x9gknd 1794 16 HBV HBV NNP cord-010119-t1x9gknd 1794 17 , , , cord-010119-t1x9gknd 1794 18 HCV HCV NNP cord-010119-t1x9gknd 1794 19 and and CC cord-010119-t1x9gknd 1794 20 HIV HIV NNP cord-010119-t1x9gknd 1794 21 , , , cord-010119-t1x9gknd 1794 22 respectively respectively RB cord-010119-t1x9gknd 1794 23 . . . cord-010119-t1x9gknd 1795 1 Linear linear JJ cord-010119-t1x9gknd 1795 2 regressions regression NNS cord-010119-t1x9gknd 1795 3 were be VBD cord-010119-t1x9gknd 1795 4 calculated calculate VBN cord-010119-t1x9gknd 1795 5 with with IN cord-010119-t1x9gknd 1795 6 p<0.05 p<0.05 NNP cord-010119-t1x9gknd 1795 7 ( ( -LRB- cord-010119-t1x9gknd 1795 8 * * NFP cord-010119-t1x9gknd 1795 9 ) ) -RRB- cord-010119-t1x9gknd 1795 10 as as IN cord-010119-t1x9gknd 1795 11 significant significant JJ cord-010119-t1x9gknd 1795 12 . . . cord-010119-t1x9gknd 1796 1 Results result NNS cord-010119-t1x9gknd 1796 2 / / SYM cord-010119-t1x9gknd 1796 3 Findings finding NNS cord-010119-t1x9gknd 1796 4 : : : cord-010119-t1x9gknd 1797 1 From from IN cord-010119-t1x9gknd 1797 2 1/1/08 1/1/08 CD cord-010119-t1x9gknd 1797 3 - - SYM cord-010119-t1x9gknd 1797 4 12/31/15 12/31/15 CD cord-010119-t1x9gknd 1797 5 , , , cord-010119-t1x9gknd 1797 6 there there EX cord-010119-t1x9gknd 1797 7 were be VBD cord-010119-t1x9gknd 1797 8 more more JJR cord-010119-t1x9gknd 1797 9 than than IN cord-010119-t1x9gknd 1797 10 48 48 CD cord-010119-t1x9gknd 1797 11 million million CD cord-010119-t1x9gknd 1797 12 donations donation NNS cord-010119-t1x9gknd 1797 13 from from IN cord-010119-t1x9gknd 1797 14 13,204,447 13,204,447 CD cord-010119-t1x9gknd 1797 15 donors donor NNS cord-010119-t1x9gknd 1797 16 ( ( -LRB- cord-010119-t1x9gknd 1797 17 51.4 51.4 CD cord-010119-t1x9gknd 1797 18 % % NN cord-010119-t1x9gknd 1797 19 female female NN cord-010119-t1x9gknd 1797 20 , , , cord-010119-t1x9gknd 1797 21 33 33 CD cord-010119-t1x9gknd 1797 22 % % NN cord-010119-t1x9gknd 1797 23 First first JJ cord-010119-t1x9gknd 1797 24 - - HYPH cord-010119-t1x9gknd 1797 25 Time time NN cord-010119-t1x9gknd 1797 26 ( ( -LRB- cord-010119-t1x9gknd 1797 27 FT FT NNP cord-010119-t1x9gknd 1797 28 ) ) -RRB- cord-010119-t1x9gknd 1797 29 , , , cord-010119-t1x9gknd 1797 30 81.4 81.4 CD cord-010119-t1x9gknd 1797 31 % % NN cord-010119-t1x9gknd 1797 32 Caucasian Caucasian NNP cord-010119-t1x9gknd 1797 33 ) ) -RRB- cord-010119-t1x9gknd 1797 34 . . . cord-010119-t1x9gknd 1798 1 There there EX cord-010119-t1x9gknd 1798 2 were be VBD cord-010119-t1x9gknd 1798 3 significant significant JJ cord-010119-t1x9gknd 1798 4 decreases decrease NNS cord-010119-t1x9gknd 1798 5 in in IN cord-010119-t1x9gknd 1798 6 donation donation NN cord-010119-t1x9gknd 1798 7 prevalence prevalence NN cord-010119-t1x9gknd 1798 8 for for IN cord-010119-t1x9gknd 1798 9 HBV HBV NNP cord-010119-t1x9gknd 1798 10 and and CC cord-010119-t1x9gknd 1798 11 HCV HCV NNP cord-010119-t1x9gknd 1798 12 ( ( -LRB- cord-010119-t1x9gknd 1798 13 p50.014 p50.014 NNS cord-010119-t1x9gknd 1798 14 and and CC cord-010119-t1x9gknd 1798 15 0.044 0.044 CD cord-010119-t1x9gknd 1798 16 ) ) -RRB- cord-010119-t1x9gknd 1798 17 , , , cord-010119-t1x9gknd 1798 18 but but CC cord-010119-t1x9gknd 1798 19 no no DT cord-010119-t1x9gknd 1798 20 significant significant JJ cord-010119-t1x9gknd 1798 21 decrease decrease NN cord-010119-t1x9gknd 1798 22 in in IN cord-010119-t1x9gknd 1798 23 HIV HIV NNP cord-010119-t1x9gknd 1798 24 during during IN cord-010119-t1x9gknd 1798 25 the the DT cord-010119-t1x9gknd 1798 26 8 8 CD cord-010119-t1x9gknd 1798 27 years year NNS cord-010119-t1x9gknd 1798 28 ( ( -LRB- cord-010119-t1x9gknd 1798 29 see see VB cord-010119-t1x9gknd 1798 30 Table Table NNP cord-010119-t1x9gknd 1798 31 for for IN cord-010119-t1x9gknd 1798 32 F F NNP cord-010119-t1x9gknd 1798 33 and and CC cord-010119-t1x9gknd 1798 34 R r NN cord-010119-t1x9gknd 1798 35 2 2 CD cord-010119-t1x9gknd 1798 36 values value NNS cord-010119-t1x9gknd 1798 37 ) ) -RRB- cord-010119-t1x9gknd 1798 38 . . . cord-010119-t1x9gknd 1799 1 A a DT cord-010119-t1x9gknd 1799 2 significant significant JJ cord-010119-t1x9gknd 1799 3 decrease decrease NN cord-010119-t1x9gknd 1799 4 was be VBD cord-010119-t1x9gknd 1799 5 seen see VBN cord-010119-t1x9gknd 1799 6 in in IN cord-010119-t1x9gknd 1799 7 FT FT NNP cord-010119-t1x9gknd 1799 8 donor donor NN cord-010119-t1x9gknd 1799 9 prevalence prevalence NN cord-010119-t1x9gknd 1799 10 for for IN cord-010119-t1x9gknd 1799 11 HBV HBV NNP cord-010119-t1x9gknd 1799 12 and and CC cord-010119-t1x9gknd 1799 13 HCV HCV NNP cord-010119-t1x9gknd 1799 14 ( ( -LRB- cord-010119-t1x9gknd 1799 15 p50.026 p50.026 NN cord-010119-t1x9gknd 1799 16 and and CC cord-010119-t1x9gknd 1799 17 0.042 0.042 CD cord-010119-t1x9gknd 1799 18 ) ) -RRB- cord-010119-t1x9gknd 1799 19 . . . cord-010119-t1x9gknd 1800 1 Prevalent prevalent JJ cord-010119-t1x9gknd 1800 2 FT FT NNP cord-010119-t1x9gknd 1800 3 donors donor NNS cord-010119-t1x9gknd 1800 4 were be VBD cord-010119-t1x9gknd 1800 5 significantly significantly RB cord-010119-t1x9gknd 1800 6 more more RBR cord-010119-t1x9gknd 1800 7 likely likely JJ cord-010119-t1x9gknd 1800 8 to to TO cord-010119-t1x9gknd 1800 9 be be VB cord-010119-t1x9gknd 1800 10 male male JJ cord-010119-t1x9gknd 1800 11 ( ( -LRB- cord-010119-t1x9gknd 1800 12 68.3 68.3 CD cord-010119-t1x9gknd 1800 13 % % NN cord-010119-t1x9gknd 1800 14 -HBV -HBV JJR cord-010119-t1x9gknd 1800 15 , , , cord-010119-t1x9gknd 1800 16 59.8 59.8 CD cord-010119-t1x9gknd 1800 17 % % NN cord-010119-t1x9gknd 1800 18 -HCV -hcv JJ cord-010119-t1x9gknd 1800 19 , , , cord-010119-t1x9gknd 1800 20 79.7 79.7 CD cord-010119-t1x9gknd 1800 21 % % NN cord-010119-t1x9gknd 1800 22 -HIV -hiv NN cord-010119-t1x9gknd 1800 23 ; ; : cord-010119-t1x9gknd 1800 24 p<0.001 p<0.001 CD cord-010119-t1x9gknd 1800 25 ) ) -RRB- cord-010119-t1x9gknd 1800 26 . . . cord-010119-t1x9gknd 1801 1 Incidence incidence NN cord-010119-t1x9gknd 1801 2 for for IN cord-010119-t1x9gknd 1801 3 all all DT cord-010119-t1x9gknd 1801 4 agents agent NNS cord-010119-t1x9gknd 1801 5 declined decline VBD cord-010119-t1x9gknd 1801 6 ( ( -LRB- cord-010119-t1x9gknd 1801 7 significant significant JJ cord-010119-t1x9gknd 1801 8 only only RB cord-010119-t1x9gknd 1801 9 for for IN cord-010119-t1x9gknd 1801 10 HBV HBV NNP cord-010119-t1x9gknd 1801 11 ; ; : cord-010119-t1x9gknd 1801 12 p50.035 p50.035 NN cord-010119-t1x9gknd 1801 13 ) ) -RRB- cord-010119-t1x9gknd 1801 14 . . . cord-010119-t1x9gknd 1802 1 The the DT cord-010119-t1x9gknd 1802 2 decrease decrease NN cord-010119-t1x9gknd 1802 3 in in IN cord-010119-t1x9gknd 1802 4 HCV HCV NNP cord-010119-t1x9gknd 1802 5 incidence incidence NN cord-010119-t1x9gknd 1802 6 was be VBD cord-010119-t1x9gknd 1802 7 not not RB cord-010119-t1x9gknd 1802 8 significant significant JJ cord-010119-t1x9gknd 1802 9 , , , cord-010119-t1x9gknd 1802 10 but but CC cord-010119-t1x9gknd 1802 11 there there EX cord-010119-t1x9gknd 1802 12 were be VBD cord-010119-t1x9gknd 1802 13 fewer few JJR cord-010119-t1x9gknd 1802 14 incident incident NN cord-010119-t1x9gknd 1802 15 donors donor NNS cord-010119-t1x9gknd 1802 16 in in IN cord-010119-t1x9gknd 1802 17 the the DT cord-010119-t1x9gknd 1802 18 last last JJ cord-010119-t1x9gknd 1802 19 2-year 2-year CD cord-010119-t1x9gknd 1802 20 period period NN cord-010119-t1x9gknd 1802 21 ( ( -LRB- cord-010119-t1x9gknd 1802 22 74 74 CD cord-010119-t1x9gknd 1802 23 in in IN cord-010119-t1x9gknd 1802 24 2012 2012 CD cord-010119-t1x9gknd 1802 25 - - SYM cord-010119-t1x9gknd 1802 26 2013 2013 CD cord-010119-t1x9gknd 1802 27 vs. vs. NN cord-010119-t1x9gknd 1802 28 19 19 CD cord-010119-t1x9gknd 1802 29 in in IN cord-010119-t1x9gknd 1802 30 2014 2014 CD cord-010119-t1x9gknd 1802 31 - - SYM cord-010119-t1x9gknd 1802 32 2015 2015 CD cord-010119-t1x9gknd 1802 33 ) ) -RRB- cord-010119-t1x9gknd 1802 34 . . . cord-010119-t1x9gknd 1803 1 HCV HCV NNP cord-010119-t1x9gknd 1803 2 incident incident NN cord-010119-t1x9gknd 1803 3 donors donor NNS cord-010119-t1x9gknd 1803 4 in in IN cord-010119-t1x9gknd 1803 5 2014 2014 CD cord-010119-t1x9gknd 1803 6 - - SYM cord-010119-t1x9gknd 1803 7 2015 2015 CD cord-010119-t1x9gknd 1803 8 were be VBD cord-010119-t1x9gknd 1803 9 more more RBR cord-010119-t1x9gknd 1803 10 likely likely JJ cord-010119-t1x9gknd 1803 11 to to TO cord-010119-t1x9gknd 1803 12 be be VB cord-010119-t1x9gknd 1803 13 male male JJ cord-010119-t1x9gknd 1803 14 ( ( -LRB- cord-010119-t1x9gknd 1803 15 79.0 79.0 CD cord-010119-t1x9gknd 1803 16 % % NN cord-010119-t1x9gknd 1803 17 vs vs IN cord-010119-t1x9gknd 1803 18 46.0 46.0 CD cord-010119-t1x9gknd 1803 19 % % NN cord-010119-t1x9gknd 1803 20 in in IN cord-010119-t1x9gknd 1803 21 2012 2012 CD cord-010119-t1x9gknd 1803 22 - - SYM cord-010119-t1x9gknd 1803 23 2013 2013 CD cord-010119-t1x9gknd 1803 24 , , , cord-010119-t1x9gknd 1803 25 p<0.001 p<0.001 CD cord-010119-t1x9gknd 1803 26 ) ) -RRB- cord-010119-t1x9gknd 1803 27 and and CC cord-010119-t1x9gknd 1803 28 were be VBD cord-010119-t1x9gknd 1803 29 younger young JJR cord-010119-t1x9gknd 1803 30 ( ( -LRB- cord-010119-t1x9gknd 1803 31 84.2 84.2 CD cord-010119-t1x9gknd 1803 32 % % NN cord-010119-t1x9gknd 1803 33 vs. vs. IN cord-010119-t1x9gknd 1803 34 67.6 67.6 CD cord-010119-t1x9gknd 1803 35 % % NN cord-010119-t1x9gknd 1803 36 in in IN cord-010119-t1x9gknd 1803 37 2012 2012 CD cord-010119-t1x9gknd 1803 38 - - SYM cord-010119-t1x9gknd 1803 39 2013 2013 CD cord-010119-t1x9gknd 1803 40 < < XX cord-010119-t1x9gknd 1803 41 40 40 CD cord-010119-t1x9gknd 1803 42 years year NNS cord-010119-t1x9gknd 1803 43 , , , cord-010119-t1x9gknd 1803 44 p50.011 p50.011 JJ cord-010119-t1x9gknd 1803 45 ) ) -RRB- cord-010119-t1x9gknd 1803 46 . . . cord-010119-t1x9gknd 1804 1 Overall overall RB cord-010119-t1x9gknd 1804 2 , , , cord-010119-t1x9gknd 1804 3 incident incident NN cord-010119-t1x9gknd 1804 4 donors donor NNS cord-010119-t1x9gknd 1804 5 were be VBD cord-010119-t1x9gknd 1804 6 more more RBR cord-010119-t1x9gknd 1804 7 likely likely JJ cord-010119-t1x9gknd 1804 8 to to TO cord-010119-t1x9gknd 1804 9 be be VB cord-010119-t1x9gknd 1804 10 Caucasian caucasian JJ cord-010119-t1x9gknd 1804 11 males male NNS cord-010119-t1x9gknd 1804 12 ( ( -LRB- cord-010119-t1x9gknd 1804 13 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 1804 14 ) ) -RRB- cord-010119-t1x9gknd 1804 15 . . . cord-010119-t1x9gknd 1805 1 RRs RRs NNP cord-010119-t1x9gknd 1805 2 for for IN cord-010119-t1x9gknd 1805 3 all all DT cord-010119-t1x9gknd 1805 4 3 3 CD cord-010119-t1x9gknd 1805 5 agents agent NNS cord-010119-t1x9gknd 1805 6 decreased decrease VBD cord-010119-t1x9gknd 1805 7 over over IN cord-010119-t1x9gknd 1805 8 time time NN cord-010119-t1x9gknd 1805 9 with with IN cord-010119-t1x9gknd 1805 10 RRs rrs NN cord-010119-t1x9gknd 1805 11 in in IN cord-010119-t1x9gknd 1805 12 2014 2014 CD cord-010119-t1x9gknd 1805 13 - - SYM cord-010119-t1x9gknd 1805 14 2015 2015 CD cord-010119-t1x9gknd 1805 15 of of IN cord-010119-t1x9gknd 1805 16 1 1 CD cord-010119-t1x9gknd 1805 17 in in IN cord-010119-t1x9gknd 1805 18 1,565,000 1,565,000 CD cord-010119-t1x9gknd 1805 19 ; ; : cord-010119-t1x9gknd 1805 20 1 1 CD cord-010119-t1x9gknd 1805 21 in in IN cord-010119-t1x9gknd 1805 22 2,680,000 2,680,000 CD cord-010119-t1x9gknd 1805 23 ; ; : cord-010119-t1x9gknd 1805 24 and and CC cord-010119-t1x9gknd 1805 25 1 1 CD cord-010119-t1x9gknd 1805 26 in in IN cord-010119-t1x9gknd 1805 27 2,435,000 2,435,000 CD cord-010119-t1x9gknd 1805 28 for for IN cord-010119-t1x9gknd 1805 29 HBV HBV NNP cord-010119-t1x9gknd 1805 30 , , , cord-010119-t1x9gknd 1805 31 HCV HCV NNP cord-010119-t1x9gknd 1805 32 and and CC cord-010119-t1x9gknd 1805 33 HIV HIV NNP cord-010119-t1x9gknd 1805 34 , , , cord-010119-t1x9gknd 1805 35 respectively respectively RB cord-010119-t1x9gknd 1805 36 . . . cord-010119-t1x9gknd 1806 1 Conclusion conclusion NN cord-010119-t1x9gknd 1806 2 : : : cord-010119-t1x9gknd 1806 3 Prevalence prevalence NN cord-010119-t1x9gknd 1806 4 , , , cord-010119-t1x9gknd 1806 5 incidence incidence NN cord-010119-t1x9gknd 1806 6 and and CC cord-010119-t1x9gknd 1806 7 RR rr NN cord-010119-t1x9gknd 1806 8 of of IN cord-010119-t1x9gknd 1806 9 HBV HBV NNP cord-010119-t1x9gknd 1806 10 , , , cord-010119-t1x9gknd 1806 11 HCV HCV NNP cord-010119-t1x9gknd 1806 12 and and CC cord-010119-t1x9gknd 1806 13 HIV HIV NNP cord-010119-t1x9gknd 1806 14 have have VBP cord-010119-t1x9gknd 1806 15 generally generally RB cord-010119-t1x9gknd 1806 16 decreased decrease VBN cord-010119-t1x9gknd 1806 17 within within IN cord-010119-t1x9gknd 1806 18 this this DT cord-010119-t1x9gknd 1806 19 blood blood NN cord-010119-t1x9gknd 1806 20 system system NN cord-010119-t1x9gknd 1806 21 over over IN cord-010119-t1x9gknd 1806 22 the the DT cord-010119-t1x9gknd 1806 23 8-year 8-year JJ cord-010119-t1x9gknd 1806 24 time time NN cord-010119-t1x9gknd 1806 25 frame frame NN cord-010119-t1x9gknd 1806 26 . . . cord-010119-t1x9gknd 1807 1 As as IN cord-010119-t1x9gknd 1807 2 donor donor NN cord-010119-t1x9gknd 1807 3 screening screening NN cord-010119-t1x9gknd 1807 4 and and CC cord-010119-t1x9gknd 1807 5 deferral deferral NN cord-010119-t1x9gknd 1807 6 regulations regulation NNS cord-010119-t1x9gknd 1807 7 evolve evolve VBP cord-010119-t1x9gknd 1807 8 , , , cord-010119-t1x9gknd 1807 9 it -PRON- PRP cord-010119-t1x9gknd 1807 10 is be VBZ cord-010119-t1x9gknd 1807 11 important important JJ cord-010119-t1x9gknd 1807 12 to to TO cord-010119-t1x9gknd 1807 13 monitor monitor VB cord-010119-t1x9gknd 1807 14 these these DT cord-010119-t1x9gknd 1807 15 risks risk NNS cord-010119-t1x9gknd 1807 16 . . . cord-010119-t1x9gknd 1808 1 It -PRON- PRP cord-010119-t1x9gknd 1808 2 is be VBZ cord-010119-t1x9gknd 1808 3 critical critical JJ cord-010119-t1x9gknd 1808 4 to to TO cord-010119-t1x9gknd 1808 5 note note VB cord-010119-t1x9gknd 1808 6 that that IN cord-010119-t1x9gknd 1808 7 even even RB cord-010119-t1x9gknd 1808 8 in in IN cord-010119-t1x9gknd 1808 9 a a DT cord-010119-t1x9gknd 1808 10 large large JJ cord-010119-t1x9gknd 1808 11 population population NN cord-010119-t1x9gknd 1808 12 , , , cord-010119-t1x9gknd 1808 13 small small JJ cord-010119-t1x9gknd 1808 14 changes change NNS cord-010119-t1x9gknd 1808 15 to to IN cord-010119-t1x9gknd 1808 16 the the DT cord-010119-t1x9gknd 1808 17 number number NN cord-010119-t1x9gknd 1808 18 of of IN cord-010119-t1x9gknd 1808 19 positives positive NNS cord-010119-t1x9gknd 1808 20 can can MD cord-010119-t1x9gknd 1808 21 have have VB cord-010119-t1x9gknd 1808 22 a a DT cord-010119-t1x9gknd 1808 23 significant significant JJ cord-010119-t1x9gknd 1808 24 impact impact NN cord-010119-t1x9gknd 1808 25 on on IN cord-010119-t1x9gknd 1808 26 prevalence prevalence NN cord-010119-t1x9gknd 1808 27 and and CC cord-010119-t1x9gknd 1808 28 incidence incidence NN cord-010119-t1x9gknd 1808 29 rates rate NNS cord-010119-t1x9gknd 1808 30 . . . cord-010119-t1x9gknd 1809 1 Furthermore furthermore RB cord-010119-t1x9gknd 1809 2 , , , cord-010119-t1x9gknd 1809 3 in in IN cord-010119-t1x9gknd 1809 4 2015 2015 CD cord-010119-t1x9gknd 1809 5 , , , cord-010119-t1x9gknd 1809 6 MAYV MAYV NNP cord-010119-t1x9gknd 1809 7 was be VBD cord-010119-t1x9gknd 1809 8 isolated isolate VBN cord-010119-t1x9gknd 1809 9 from from IN cord-010119-t1x9gknd 1809 10 a a DT cord-010119-t1x9gknd 1809 11 patient patient NN cord-010119-t1x9gknd 1809 12 in in IN cord-010119-t1x9gknd 1809 13 Haiti Haiti NNP cord-010119-t1x9gknd 1809 14 , , , cord-010119-t1x9gknd 1809 15 suggesting suggest VBG cord-010119-t1x9gknd 1809 16 the the DT cord-010119-t1x9gknd 1809 17 virus virus NN cord-010119-t1x9gknd 1809 18 is be VBZ cord-010119-t1x9gknd 1809 19 already already RB cord-010119-t1x9gknd 1809 20 circulating circulate VBG cord-010119-t1x9gknd 1809 21 in in IN cord-010119-t1x9gknd 1809 22 the the DT cord-010119-t1x9gknd 1809 23 Caribbean Caribbean NNP cord-010119-t1x9gknd 1809 24 . . . cord-010119-t1x9gknd 1810 1 The the DT cord-010119-t1x9gknd 1810 2 extent extent NN cord-010119-t1x9gknd 1810 3 of of IN cord-010119-t1x9gknd 1810 4 MAYV MAYV NNP cord-010119-t1x9gknd 1810 5 transmission transmission NN cord-010119-t1x9gknd 1810 6 could could MD cord-010119-t1x9gknd 1810 7 be be VB cord-010119-t1x9gknd 1810 8 underestimated underestimate VBN cord-010119-t1x9gknd 1810 9 due due IN cord-010119-t1x9gknd 1810 10 to to IN cord-010119-t1x9gknd 1810 11 limited limited JJ cord-010119-t1x9gknd 1810 12 surveillance surveillance NN cord-010119-t1x9gknd 1810 13 and and CC cord-010119-t1x9gknd 1810 14 diagnostic diagnostic JJ cord-010119-t1x9gknd 1810 15 capabilities capability NNS cord-010119-t1x9gknd 1810 16 ; ; : cord-010119-t1x9gknd 1810 17 therefore therefore RB cord-010119-t1x9gknd 1810 18 , , , cord-010119-t1x9gknd 1810 19 it -PRON- PRP cord-010119-t1x9gknd 1810 20 is be VBZ cord-010119-t1x9gknd 1810 21 necessary necessary JJ cord-010119-t1x9gknd 1810 22 to to TO cord-010119-t1x9gknd 1810 23 be be VB cord-010119-t1x9gknd 1810 24 prepared prepare VBN cord-010119-t1x9gknd 1810 25 for for IN cord-010119-t1x9gknd 1810 26 MAYV MAYV NNP cord-010119-t1x9gknd 1810 27 emergence emergence NN cord-010119-t1x9gknd 1810 28 and and CC cord-010119-t1x9gknd 1810 29 the the DT cord-010119-t1x9gknd 1810 30 potential potential JJ cord-010119-t1x9gknd 1810 31 risk risk NN cord-010119-t1x9gknd 1810 32 for for IN cord-010119-t1x9gknd 1810 33 the the DT cord-010119-t1x9gknd 1810 34 blood blood NN cord-010119-t1x9gknd 1810 35 supply supply NN cord-010119-t1x9gknd 1810 36 in in IN cord-010119-t1x9gknd 1810 37 case case NN cord-010119-t1x9gknd 1810 38 it -PRON- PRP cord-010119-t1x9gknd 1810 39 can can MD cord-010119-t1x9gknd 1810 40 be be VB cord-010119-t1x9gknd 1810 41 transmitted transmit VBN cord-010119-t1x9gknd 1810 42 through through IN cord-010119-t1x9gknd 1810 43 blood blood NN cord-010119-t1x9gknd 1810 44 transfusion transfusion NN cord-010119-t1x9gknd 1810 45 . . . cord-010119-t1x9gknd 1811 1 Study Study NNP cord-010119-t1x9gknd 1811 2 Design Design NNP cord-010119-t1x9gknd 1811 3 / / SYM cord-010119-t1x9gknd 1811 4 Method method NN cord-010119-t1x9gknd 1811 5 : : : cord-010119-t1x9gknd 1811 6 Platelet platelet NN cord-010119-t1x9gknd 1811 7 components component NNS cord-010119-t1x9gknd 1811 8 ( ( -LRB- cord-010119-t1x9gknd 1811 9 PC pc NN cord-010119-t1x9gknd 1811 10 ) ) -RRB- cord-010119-t1x9gknd 1811 11 prepared prepare VBN cord-010119-t1x9gknd 1811 12 in in IN cord-010119-t1x9gknd 1811 13 PAS PAS NNP cord-010119-t1x9gknd 1811 14 were be VBD cord-010119-t1x9gknd 1811 15 spiked spike VBN cord-010119-t1x9gknd 1811 16 with with IN cord-010119-t1x9gknd 1811 17 MAYV MAYV NNP cord-010119-t1x9gknd 1811 18 and and CC cord-010119-t1x9gknd 1811 19 treated treat VBN cord-010119-t1x9gknd 1811 20 with with IN cord-010119-t1x9gknd 1811 21 amotosalen amotosalen NN cord-010119-t1x9gknd 1811 22 and and CC cord-010119-t1x9gknd 1811 23 UVA UVA NNP cord-010119-t1x9gknd 1811 24 illumination illumination NN cord-010119-t1x9gknd 1811 25 . . . cord-010119-t1x9gknd 1812 1 Samples sample NNS cord-010119-t1x9gknd 1812 2 were be VBD cord-010119-t1x9gknd 1812 3 collected collect VBN cord-010119-t1x9gknd 1812 4 pre pre JJ cord-010119-t1x9gknd 1812 5 - - JJ cord-010119-t1x9gknd 1812 6 UVA UVA NNP cord-010119-t1x9gknd 1812 7 and and CC cord-010119-t1x9gknd 1812 8 post post JJ cord-010119-t1x9gknd 1812 9 - - JJ cord-010119-t1x9gknd 1812 10 UVA uva JJ cord-010119-t1x9gknd 1812 11 illumination illumination NN cord-010119-t1x9gknd 1812 12 for for IN cord-010119-t1x9gknd 1812 13 infectious infectious JJ cord-010119-t1x9gknd 1812 14 titer titer NN cord-010119-t1x9gknd 1812 15 determination determination NN cord-010119-t1x9gknd 1812 16 . . . cord-010119-t1x9gknd 1813 1 AS-5 as-5 NN cord-010119-t1x9gknd 1814 1 RBCs rbc NNS cord-010119-t1x9gknd 1814 2 were be VBD cord-010119-t1x9gknd 1814 3 spiked spike VBN cord-010119-t1x9gknd 1814 4 with with IN cord-010119-t1x9gknd 1814 5 MAYV MAYV NNP cord-010119-t1x9gknd 1814 6 , , , cord-010119-t1x9gknd 1814 7 mixed mix VBN cord-010119-t1x9gknd 1814 8 with with IN cord-010119-t1x9gknd 1814 9 glutathione glutathione NN cord-010119-t1x9gknd 1814 10 ( ( -LRB- cord-010119-t1x9gknd 1814 11 GSH)/Processing gsh)/processe VBG cord-010119-t1x9gknd 1814 12 solution solution NN cord-010119-t1x9gknd 1814 13 , , , cord-010119-t1x9gknd 1814 14 dosed dose VBN cord-010119-t1x9gknd 1814 15 with with IN cord-010119-t1x9gknd 1814 16 200lM 200lm CD cord-010119-t1x9gknd 1814 17 amustaline amustaline NNP cord-010119-t1x9gknd 1814 18 , , , cord-010119-t1x9gknd 1814 19 and and CC cord-010119-t1x9gknd 1814 20 incubated incubate VBN cord-010119-t1x9gknd 1814 21 for for IN cord-010119-t1x9gknd 1814 22 18hrs 18hrs CD cord-010119-t1x9gknd 1814 23 at at IN cord-010119-t1x9gknd 1814 24 room room NN cord-010119-t1x9gknd 1814 25 temperature temperature NN cord-010119-t1x9gknd 1814 26 . . . cord-010119-t1x9gknd 1815 1 Samples sample NNS cord-010119-t1x9gknd 1815 2 were be VBD cord-010119-t1x9gknd 1815 3 collected collect VBN cord-010119-t1x9gknd 1815 4 prior prior RB cord-010119-t1x9gknd 1815 5 to to IN cord-010119-t1x9gknd 1815 6 the the DT cord-010119-t1x9gknd 1815 7 addition addition NN cord-010119-t1x9gknd 1815 8 of of IN cord-010119-t1x9gknd 1815 9 amustaline amustaline NNP cord-010119-t1x9gknd 1815 10 ( ( -LRB- cord-010119-t1x9gknd 1815 11 pre pre JJ cord-010119-t1x9gknd 1815 12 - - JJ cord-010119-t1x9gknd 1815 13 treatment treatment JJ cord-010119-t1x9gknd 1815 14 ) ) -RRB- cord-010119-t1x9gknd 1815 15 and and CC cord-010119-t1x9gknd 1815 16 following follow VBG cord-010119-t1x9gknd 1815 17 the the DT cord-010119-t1x9gknd 1815 18 3hr 3hr JJ cord-010119-t1x9gknd 1815 19 incubation incubation NN cord-010119-t1x9gknd 1815 20 ( ( -LRB- cord-010119-t1x9gknd 1815 21 post post JJ cord-010119-t1x9gknd 1815 22 - - JJ cord-010119-t1x9gknd 1815 23 treatment treatment NN cord-010119-t1x9gknd 1815 24 ) ) -RRB- cord-010119-t1x9gknd 1815 25 to to TO cord-010119-t1x9gknd 1815 26 determine determine VB cord-010119-t1x9gknd 1815 27 infectious infectious JJ cord-010119-t1x9gknd 1815 28 titers titer NNS cord-010119-t1x9gknd 1815 29 . . . cord-010119-t1x9gknd 1816 1 Infectious infectious JJ cord-010119-t1x9gknd 1816 2 titers titer NNS cord-010119-t1x9gknd 1816 3 for for IN cord-010119-t1x9gknd 1816 4 all all DT cord-010119-t1x9gknd 1816 5 samples sample NNS cord-010119-t1x9gknd 1816 6 were be VBD cord-010119-t1x9gknd 1816 7 determined determine VBN cord-010119-t1x9gknd 1816 8 by by IN cord-010119-t1x9gknd 1816 9 plaque plaque NN cord-010119-t1x9gknd 1816 10 assay assay NN cord-010119-t1x9gknd 1816 11 on on IN cord-010119-t1x9gknd 1816 12 Vero76 Vero76 NNP cord-010119-t1x9gknd 1816 13 cells cell NNS cord-010119-t1x9gknd 1816 14 . . . cord-010119-t1x9gknd 1817 1 The the DT cord-010119-t1x9gknd 1817 2 extent extent NN cord-010119-t1x9gknd 1817 3 of of IN cord-010119-t1x9gknd 1817 4 inactivation inactivation NN cord-010119-t1x9gknd 1817 5 was be VBD cord-010119-t1x9gknd 1817 6 determined determine VBN cord-010119-t1x9gknd 1817 7 by by IN cord-010119-t1x9gknd 1817 8 comparing compare VBG cord-010119-t1x9gknd 1817 9 the the DT cord-010119-t1x9gknd 1817 10 infectious infectious JJ cord-010119-t1x9gknd 1817 11 titers titer NNS cord-010119-t1x9gknd 1817 12 ( ( -LRB- cord-010119-t1x9gknd 1817 13 plaque plaque NN cord-010119-t1x9gknd 1817 14 forming form VBG cord-010119-t1x9gknd 1817 15 units unit NNS cord-010119-t1x9gknd 1817 16 ( ( -LRB- cord-010119-t1x9gknd 1817 17 PFU)/mL pfu)/ml RB cord-010119-t1x9gknd 1817 18 ) ) -RRB- cord-010119-t1x9gknd 1817 19 in in IN cord-010119-t1x9gknd 1817 20 pre pre NN cord-010119-t1x9gknd 1817 21 - - NN cord-010119-t1x9gknd 1817 22 vs vs RP cord-010119-t1x9gknd 1817 23 . . . cord-010119-t1x9gknd 1818 1 post post JJ cord-010119-t1x9gknd 1818 2 - - JJ cord-010119-t1x9gknd 1818 3 treatment treatment JJ cord-010119-t1x9gknd 1818 4 samples sample NNS cord-010119-t1x9gknd 1818 5 . . . cord-010119-t1x9gknd 1819 1 Results/ Results/ . cord-010119-t1x9gknd 1820 1 Finding finding NN cord-010119-t1x9gknd 1820 2 : : : cord-010119-t1x9gknd 1820 3 MAYV MAYV NNP cord-010119-t1x9gknd 1820 4 was be VBD cord-010119-t1x9gknd 1820 5 inactivated inactivate VBN cord-010119-t1x9gknd 1820 6 to to IN cord-010119-t1x9gknd 1820 7 the the DT cord-010119-t1x9gknd 1820 8 limit limit NN cord-010119-t1x9gknd 1820 9 of of IN cord-010119-t1x9gknd 1820 10 detection detection NN cord-010119-t1x9gknd 1820 11 in in IN cord-010119-t1x9gknd 1820 12 both both CC cord-010119-t1x9gknd 1820 13 PC pc NN cord-010119-t1x9gknd 1820 14 and and CC cord-010119-t1x9gknd 1820 15 RBCs rbc NNS cord-010119-t1x9gknd 1820 16 . . . cord-010119-t1x9gknd 1821 1 In in IN cord-010119-t1x9gknd 1821 2 platelets platelet NNS cord-010119-t1x9gknd 1821 3 , , , cord-010119-t1x9gknd 1821 4 > > XX cord-010119-t1x9gknd 1821 5 6.9 6.9 CD cord-010119-t1x9gknd 1821 6 log log NN cord-010119-t1x9gknd 1821 7 10 10 CD cord-010119-t1x9gknd 1821 8 , , , cord-010119-t1x9gknd 1821 9 or or CC cord-010119-t1x9gknd 1821 10 > > XX cord-010119-t1x9gknd 1821 11 6.2 6.2 CD cord-010119-t1x9gknd 1821 12 log log NN cord-010119-t1x9gknd 1822 1 10 10 CD cord-010119-t1x9gknd 1822 2 PFU pfu NN cord-010119-t1x9gknd 1822 3 / / SYM cord-010119-t1x9gknd 1822 4 mL ml NN cord-010119-t1x9gknd 1822 5 , , , cord-010119-t1x9gknd 1822 6 inactivation inactivation NN cord-010119-t1x9gknd 1822 7 of of IN cord-010119-t1x9gknd 1822 8 MAYV MAYV NNP cord-010119-t1x9gknd 1822 9 was be VBD cord-010119-t1x9gknd 1822 10 achieved achieve VBN cord-010119-t1x9gknd 1822 11 . . . cord-010119-t1x9gknd 1823 1 In in IN cord-010119-t1x9gknd 1823 2 RBCs rbc NNS cord-010119-t1x9gknd 1823 3 , , , cord-010119-t1x9gknd 1823 4 inactivation inactivation NN cord-010119-t1x9gknd 1823 5 of of IN cord-010119-t1x9gknd 1823 6 MAYV MAYV NNP cord-010119-t1x9gknd 1823 7 was be VBD cord-010119-t1x9gknd 1823 8 > > NFP cord-010119-t1x9gknd 1823 9 6.2 6.2 CD cord-010119-t1x9gknd 1823 10 log log NN cord-010119-t1x9gknd 1823 11 10 10 CD cord-010119-t1x9gknd 1823 12 , , , cord-010119-t1x9gknd 1823 13 or or CC cord-010119-t1x9gknd 1823 14 > > XX cord-010119-t1x9gknd 1823 15 5.5 5.5 CD cord-010119-t1x9gknd 1823 16 log log NN cord-010119-t1x9gknd 1824 1 10 10 CD cord-010119-t1x9gknd 1824 2 PFU pfu NN cord-010119-t1x9gknd 1824 3 / / SYM cord-010119-t1x9gknd 1824 4 mL. mL. NNP cord-010119-t1x9gknd 1824 5 Conclusion conclusion NN cord-010119-t1x9gknd 1824 6 : : : cord-010119-t1x9gknd 1825 1 This this DT cord-010119-t1x9gknd 1825 2 study study NN cord-010119-t1x9gknd 1825 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 1825 4 robust robust JJ cord-010119-t1x9gknd 1825 5 inactivation inactivation NN cord-010119-t1x9gknd 1825 6 of of IN cord-010119-t1x9gknd 1825 7 MAYV MAYV NNP cord-010119-t1x9gknd 1825 8 by by IN cord-010119-t1x9gknd 1825 9 both both DT cord-010119-t1x9gknd 1825 10 amotosalen amotosalen NNP cord-010119-t1x9gknd 1825 11 / / SYM cord-010119-t1x9gknd 1825 12 UVA UVA NNP cord-010119-t1x9gknd 1825 13 treatment treatment NN cord-010119-t1x9gknd 1825 14 in in IN cord-010119-t1x9gknd 1825 15 PC pc NN cord-010119-t1x9gknd 1825 16 and and CC cord-010119-t1x9gknd 1825 17 amustaline amustaline NN cord-010119-t1x9gknd 1825 18 / / SYM cord-010119-t1x9gknd 1825 19 GSH GSH NNP cord-010119-t1x9gknd 1825 20 treatment treatment NN cord-010119-t1x9gknd 1825 21 in in IN cord-010119-t1x9gknd 1825 22 RBCs rbc NNS cord-010119-t1x9gknd 1825 23 . . . cord-010119-t1x9gknd 1826 1 These these DT cord-010119-t1x9gknd 1826 2 systems system NNS cord-010119-t1x9gknd 1826 3 are be VBP cord-010119-t1x9gknd 1826 4 efficient efficient JJ cord-010119-t1x9gknd 1826 5 at at IN cord-010119-t1x9gknd 1826 6 inactivating inactivate VBG cord-010119-t1x9gknd 1826 7 Alphaviruses Alphaviruses NNP cord-010119-t1x9gknd 1826 8 that that WDT cord-010119-t1x9gknd 1826 9 have have VBP cord-010119-t1x9gknd 1826 10 demonstrated demonstrate VBN cord-010119-t1x9gknd 1826 11 or or CC cord-010119-t1x9gknd 1826 12 have have VB cord-010119-t1x9gknd 1826 13 the the DT cord-010119-t1x9gknd 1826 14 potential potential NN cord-010119-t1x9gknd 1826 15 for for IN cord-010119-t1x9gknd 1826 16 transfusion transfusion NN cord-010119-t1x9gknd 1826 17 - - HYPH cord-010119-t1x9gknd 1826 18 transmission transmission NN cord-010119-t1x9gknd 1826 19 , , , cord-010119-t1x9gknd 1826 20 including include VBG cord-010119-t1x9gknd 1826 21 MAYV MAYV NNP cord-010119-t1x9gknd 1826 22 , , , cord-010119-t1x9gknd 1826 23 CHIKV CHIKV NNP cord-010119-t1x9gknd 1826 24 and and CC cord-010119-t1x9gknd 1826 25 RRV RRV NNP cord-010119-t1x9gknd 1826 26 . . . cord-010119-t1x9gknd 1827 1 PRT PRT NNP cord-010119-t1x9gknd 1827 2 offers offer VBZ cord-010119-t1x9gknd 1827 3 potential potential NN cord-010119-t1x9gknd 1827 4 as as IN cord-010119-t1x9gknd 1827 5 a a DT cord-010119-t1x9gknd 1827 6 mitigation mitigation NN cord-010119-t1x9gknd 1827 7 strategy strategy NN cord-010119-t1x9gknd 1827 8 for for IN cord-010119-t1x9gknd 1827 9 maintaining maintain VBG cord-010119-t1x9gknd 1827 10 blood blood NN cord-010119-t1x9gknd 1827 11 component component NN cord-010119-t1x9gknd 1827 12 availability availability NN cord-010119-t1x9gknd 1827 13 in in IN cord-010119-t1x9gknd 1827 14 areas area NNS cord-010119-t1x9gknd 1827 15 where where WRB cord-010119-t1x9gknd 1827 16 multiple multiple JJ cord-010119-t1x9gknd 1827 17 Alphaviruses Alphaviruses NNP cord-010119-t1x9gknd 1827 18 are be VBP cord-010119-t1x9gknd 1827 19 epidemic epidemic NN cord-010119-t1x9gknd 1827 20 or or CC cord-010119-t1x9gknd 1827 21 endemic endemic JJ cord-010119-t1x9gknd 1827 22 , , , cord-010119-t1x9gknd 1827 23 and and CC cord-010119-t1x9gknd 1827 24 testing testing NN cord-010119-t1x9gknd 1827 25 is be VBZ cord-010119-t1x9gknd 1827 26 not not RB cord-010119-t1x9gknd 1827 27 feasible feasible JJ cord-010119-t1x9gknd 1827 28 . . . cord-010119-t1x9gknd 1828 1 ( ( -LRB- cord-010119-t1x9gknd 1828 2 Data datum NNS cord-010119-t1x9gknd 1828 3 have have VBP cord-010119-t1x9gknd 1828 4 not not RB cord-010119-t1x9gknd 1828 5 been be VBN cord-010119-t1x9gknd 1828 6 submitted submit VBN cord-010119-t1x9gknd 1828 7 for for IN cord-010119-t1x9gknd 1828 8 FDA FDA NNP cord-010119-t1x9gknd 1828 9 review review NN cord-010119-t1x9gknd 1828 10 and and CC cord-010119-t1x9gknd 1828 11 INTERCEPT intercept VB cord-010119-t1x9gknd 1828 12 for for IN cord-010119-t1x9gknd 1828 13 red red JJ cord-010119-t1x9gknd 1828 14 blood blood NN cord-010119-t1x9gknd 1828 15 cell cell NN cord-010119-t1x9gknd 1828 16 is be VBZ cord-010119-t1x9gknd 1828 17 not not RB cord-010119-t1x9gknd 1828 18 approved approve VBN cord-010119-t1x9gknd 1828 19 for for IN cord-010119-t1x9gknd 1828 20 commercial commercial JJ cord-010119-t1x9gknd 1828 21 use use NN cord-010119-t1x9gknd 1828 22 ) ) -RRB- cord-010119-t1x9gknd 1828 23 . . . cord-010119-t1x9gknd 1829 1 Thrombotic Thrombotic NNP cord-010119-t1x9gknd 1829 2 Thrombocytopenic Thrombocytopenic NNP cord-010119-t1x9gknd 1829 3 Purpura Purpura NNP cord-010119-t1x9gknd 1829 4 with with IN cord-010119-t1x9gknd 1829 5 High High NNP cord-010119-t1x9gknd 1829 6 Adamts-13 adamts-13 NN cord-010119-t1x9gknd 1829 7 Inhibitor inhibitor NN cord-010119-t1x9gknd 1830 1 May May MD cord-010119-t1x9gknd 1830 2 Represent represent VB cord-010119-t1x9gknd 1830 3 a a DT cord-010119-t1x9gknd 1830 4 Distinct Distinct NNP cord-010119-t1x9gknd 1830 5 Disease Disease NNP cord-010119-t1x9gknd 1830 6 Subset Subset NNP cord-010119-t1x9gknd 1830 7 in in IN cord-010119-t1x9gknd 1830 8 Response response NN cord-010119-t1x9gknd 1830 9 to to IN cord-010119-t1x9gknd 1830 10 Therapy Therapy NNP cord-010119-t1x9gknd 1830 11 Based base VBN cord-010119-t1x9gknd 1830 12 on on IN cord-010119-t1x9gknd 1830 13 Immature Immature NNP cord-010119-t1x9gknd 1830 14 Platelet Platelet NNP cord-010119-t1x9gknd 1830 15 Count Count NNP cord-010119-t1x9gknd 1830 16 ( ( -LRB- cord-010119-t1x9gknd 1830 17 A A NNP cord-010119-t1x9gknd 1830 18 - - HYPH cord-010119-t1x9gknd 1830 19 IPC IPC NNP cord-010119-t1x9gknd 1830 20 ) ) -RRB- cord-010119-t1x9gknd 1830 21 Dynamics Dynamics NNPS cord-010119-t1x9gknd 1830 22 Hamza Hamza NNP cord-010119-t1x9gknd 1830 23 N n CD cord-010119-t1x9gknd 1830 24 Gokozan Gokozan NNP cord-010119-t1x9gknd 1831 1 * * NFP cord-010119-t1x9gknd 1831 2 1,2 1,2 CD cord-010119-t1x9gknd 1831 3 , , , cord-010119-t1x9gknd 1831 4 Hollie Hollie NNP cord-010119-t1x9gknd 1831 5 M M NNP cord-010119-t1x9gknd 1831 6 Reeves Reeves NNP cord-010119-t1x9gknd 1831 7 1,2 1,2 CD cord-010119-t1x9gknd 1831 8 and and CC cord-010119-t1x9gknd 1831 9 Robert Robert NNP cord-010119-t1x9gknd 1831 10 W W NNP cord-010119-t1x9gknd 1831 11 Maitta Maitta NNP cord-010119-t1x9gknd 1831 12 1,2 1,2 CD cord-010119-t1x9gknd 1831 13 . . . cord-010119-t1x9gknd 1832 1 1 1 LS cord-010119-t1x9gknd 1833 1 Case Case NNP cord-010119-t1x9gknd 1833 2 Western Western NNP cord-010119-t1x9gknd 1833 3 Reserve Reserve NNP cord-010119-t1x9gknd 1833 4 University University NNP cord-010119-t1x9gknd 1833 5 School School NNP cord-010119-t1x9gknd 1833 6 of of IN cord-010119-t1x9gknd 1833 7 Medicine Medicine NNP cord-010119-t1x9gknd 1833 8 , , , cord-010119-t1x9gknd 1833 9 2 2 CD cord-010119-t1x9gknd 1833 10 University University NNP cord-010119-t1x9gknd 1833 11 Hospitals Hospitals NNPS cord-010119-t1x9gknd 1833 12 Cleveland Cleveland NNP cord-010119-t1x9gknd 1833 13 Medical Medical NNP cord-010119-t1x9gknd 1833 14 Center Center NNP cord-010119-t1x9gknd 1833 15 Background Background NNP cord-010119-t1x9gknd 1833 16 / / SYM cord-010119-t1x9gknd 1833 17 Case Case NNP cord-010119-t1x9gknd 1833 18 Studies Studies NNPS cord-010119-t1x9gknd 1833 19 : : : cord-010119-t1x9gknd 1834 1 Thrombotic thrombotic JJ cord-010119-t1x9gknd 1834 2 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 1834 3 purpura purpura NN cord-010119-t1x9gknd 1834 4 is be VBZ cord-010119-t1x9gknd 1834 5 a a DT cord-010119-t1x9gknd 1834 6 lifethreating lifethreate VBG cord-010119-t1x9gknd 1834 7 consumptive consumptive JJ cord-010119-t1x9gknd 1834 8 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 1834 9 and and CC cord-010119-t1x9gknd 1834 10 microangiopathic microangiopathic JJ cord-010119-t1x9gknd 1834 11 hemolytic hemolytic JJ cord-010119-t1x9gknd 1834 12 anemia anemia NN cord-010119-t1x9gknd 1834 13 causing cause VBG cord-010119-t1x9gknd 1834 14 diffuse diffuse JJ cord-010119-t1x9gknd 1834 15 ischemic ischemic JJ cord-010119-t1x9gknd 1834 16 damage damage NN cord-010119-t1x9gknd 1834 17 to to IN cord-010119-t1x9gknd 1834 18 tissues tissue NNS cord-010119-t1x9gknd 1834 19 . . . cord-010119-t1x9gknd 1835 1 Early early JJ cord-010119-t1x9gknd 1835 2 therapeutic therapeutic JJ cord-010119-t1x9gknd 1835 3 plasma plasma NN cord-010119-t1x9gknd 1835 4 exchange exchange NN cord-010119-t1x9gknd 1835 5 ( ( -LRB- cord-010119-t1x9gknd 1835 6 TPE TPE NNP cord-010119-t1x9gknd 1835 7 ) ) -RRB- cord-010119-t1x9gknd 1835 8 initiation initiation NN cord-010119-t1x9gknd 1835 9 has have VBZ cord-010119-t1x9gknd 1835 10 improved improve VBN cord-010119-t1x9gknd 1835 11 survival survival NN cord-010119-t1x9gknd 1835 12 . . . cord-010119-t1x9gknd 1836 1 Absolute absolute JJ cord-010119-t1x9gknd 1836 2 immature immature JJ cord-010119-t1x9gknd 1836 3 platelet platelet NN cord-010119-t1x9gknd 1836 4 count count NN cord-010119-t1x9gknd 1836 5 ( ( -LRB- cord-010119-t1x9gknd 1836 6 A A NNP cord-010119-t1x9gknd 1836 7 - - HYPH cord-010119-t1x9gknd 1836 8 IPC IPC NNP cord-010119-t1x9gknd 1836 9 ) ) -RRB- cord-010119-t1x9gknd 1836 10 has have VBZ cord-010119-t1x9gknd 1836 11 been be VBN cord-010119-t1x9gknd 1836 12 found find VBN cord-010119-t1x9gknd 1836 13 to to TO cord-010119-t1x9gknd 1836 14 aid aid VB cord-010119-t1x9gknd 1836 15 in in IN cord-010119-t1x9gknd 1836 16 diagnosis diagnosis NN cord-010119-t1x9gknd 1836 17 and and CC cord-010119-t1x9gknd 1836 18 follow follow NN cord-010119-t1x9gknd 1836 19 - - HYPH cord-010119-t1x9gknd 1836 20 up up NN cord-010119-t1x9gknd 1836 21 of of IN cord-010119-t1x9gknd 1836 22 TTP TTP NNP cord-010119-t1x9gknd 1836 23 patients patient NNS cord-010119-t1x9gknd 1836 24 . . . cord-010119-t1x9gknd 1837 1 A a LS cord-010119-t1x9gknd 1837 2 - - HYPH cord-010119-t1x9gknd 1837 3 IPC IPC NNP cord-010119-t1x9gknd 1837 4 changes change NNS cord-010119-t1x9gknd 1837 5 in in IN cord-010119-t1x9gknd 1837 6 response response NN cord-010119-t1x9gknd 1837 7 to to IN cord-010119-t1x9gknd 1837 8 therapy therapy NN cord-010119-t1x9gknd 1837 9 in in IN cord-010119-t1x9gknd 1837 10 patients patient NNS cord-010119-t1x9gknd 1837 11 with with IN cord-010119-t1x9gknd 1837 12 low low JJ cord-010119-t1x9gknd 1837 13 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 1837 14 activity activity NN cord-010119-t1x9gknd 1837 15 and and CC cord-010119-t1x9gknd 1837 16 high high JJ cord-010119-t1x9gknd 1837 17 inhibitor inhibitor NN cord-010119-t1x9gknd 1837 18 have have VBP cord-010119-t1x9gknd 1837 19 not not RB cord-010119-t1x9gknd 1837 20 been be VBN cord-010119-t1x9gknd 1837 21 analyzed analyze VBN cord-010119-t1x9gknd 1837 22 in in IN cord-010119-t1x9gknd 1837 23 a a DT cord-010119-t1x9gknd 1837 24 patient patient JJ cord-010119-t1x9gknd 1837 25 cohort cohort NN cord-010119-t1x9gknd 1837 26 . . . cord-010119-t1x9gknd 1838 1 We -PRON- PRP cord-010119-t1x9gknd 1838 2 analyzed analyze VBD cord-010119-t1x9gknd 1838 3 A A NNP cord-010119-t1x9gknd 1838 4 - - HYPH cord-010119-t1x9gknd 1838 5 IPC IPC NNP cord-010119-t1x9gknd 1838 6 response response NN cord-010119-t1x9gknd 1838 7 to to IN cord-010119-t1x9gknd 1838 8 therapy therapy NN cord-010119-t1x9gknd 1838 9 in in IN cord-010119-t1x9gknd 1838 10 five five CD cord-010119-t1x9gknd 1838 11 patients patient NNS cord-010119-t1x9gknd 1838 12 with with IN cord-010119-t1x9gknd 1838 13 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 1838 14 deficiency deficiency NN cord-010119-t1x9gknd 1838 15 and and CC cord-010119-t1x9gknd 1838 16 high high JJ cord-010119-t1x9gknd 1838 17 inhibitor inhibitor NN cord-010119-t1x9gknd 1838 18 at at IN cord-010119-t1x9gknd 1838 19 a a DT cord-010119-t1x9gknd 1838 20 large large JJ cord-010119-t1x9gknd 1838 21 tertiary tertiary JJ cord-010119-t1x9gknd 1838 22 academic academic JJ cord-010119-t1x9gknd 1838 23 medical medical JJ cord-010119-t1x9gknd 1838 24 center center NN cord-010119-t1x9gknd 1838 25 . . . cord-010119-t1x9gknd 1839 1 Study Study NNP cord-010119-t1x9gknd 1839 2 Design Design NNP cord-010119-t1x9gknd 1839 3 / / SYM cord-010119-t1x9gknd 1839 4 Method method NN cord-010119-t1x9gknd 1839 5 : : : cord-010119-t1x9gknd 1839 6 Patients patient NNS cord-010119-t1x9gknd 1839 7 had have VBD cord-010119-t1x9gknd 1839 8 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 1839 9 activity activity NN cord-010119-t1x9gknd 1839 10 of of IN cord-010119-t1x9gknd 1839 11 < < NNP cord-010119-t1x9gknd 1839 12 5 5 CD cord-010119-t1x9gknd 1839 13 % % NN cord-010119-t1x9gknd 1839 14 and and CC cord-010119-t1x9gknd 1839 15 high high JJ cord-010119-t1x9gknd 1839 16 inhibitor inhibitor NN cord-010119-t1x9gknd 1839 17 ( ( -LRB- cord-010119-t1x9gknd 1839 18 1.4 1.4 CD cord-010119-t1x9gknd 1839 19 - - SYM cord-010119-t1x9gknd 1839 20 8 8 CD cord-010119-t1x9gknd 1839 21 ) ) -RRB- cord-010119-t1x9gknd 1839 22 . . . cord-010119-t1x9gknd 1840 1 Mean mean JJ cord-010119-t1x9gknd 1840 2 age age NN cord-010119-t1x9gknd 1840 3 of of IN cord-010119-t1x9gknd 1840 4 cohort cohort NN cord-010119-t1x9gknd 1840 5 22.8 22.8 CD cord-010119-t1x9gknd 1840 6 years year NNS cord-010119-t1x9gknd 1841 1 ( ( -LRB- cord-010119-t1x9gknd 1841 2 range range NNP cord-010119-t1x9gknd 1841 3 17 17 CD cord-010119-t1x9gknd 1841 4 - - SYM cord-010119-t1x9gknd 1841 5 64 64 CD cord-010119-t1x9gknd 1841 6 ) ) -RRB- cord-010119-t1x9gknd 1841 7 . . . cord-010119-t1x9gknd 1842 1 Four four CD cord-010119-t1x9gknd 1842 2 patients patient NNS cord-010119-t1x9gknd 1842 3 were be VBD cord-010119-t1x9gknd 1842 4 female female JJ cord-010119-t1x9gknd 1842 5 and and CC cord-010119-t1x9gknd 1842 6 one one CD cord-010119-t1x9gknd 1842 7 was be VBD cord-010119-t1x9gknd 1842 8 male male JJ cord-010119-t1x9gknd 1842 9 . . . cord-010119-t1x9gknd 1843 1 Patients patient NNS cord-010119-t1x9gknd 1843 2 presented present VBN cord-010119-t1x9gknd 1843 3 with with IN cord-010119-t1x9gknd 1843 4 microangiopathic microangiopathic JJ cord-010119-t1x9gknd 1843 5 hemolytic hemolytic JJ cord-010119-t1x9gknd 1843 6 anemia anemia NN cord-010119-t1x9gknd 1843 7 , , , cord-010119-t1x9gknd 1843 8 thrombocytopenia thrombocytopenia NNP cord-010119-t1x9gknd 1844 1 ( ( -LRB- cord-010119-t1x9gknd 1844 2 mean mean VB cord-010119-t1x9gknd 1844 3 15.2 15.2 CD cord-010119-t1x9gknd 1844 4 x x SYM cord-010119-t1x9gknd 1844 5 10 10 CD cord-010119-t1x9gknd 1844 6 9 9 CD cord-010119-t1x9gknd 1844 7 /L /l CD cord-010119-t1x9gknd 1844 8 , , , cord-010119-t1x9gknd 1844 9 range range VBP cord-010119-t1x9gknd 1844 10 9 9 CD cord-010119-t1x9gknd 1844 11 -27 -27 CD cord-010119-t1x9gknd 1844 12 x x SYM cord-010119-t1x9gknd 1844 13 10 10 CD cord-010119-t1x9gknd 1844 14 9 9 CD cord-010119-t1x9gknd 1844 15 /L /l CD cord-010119-t1x9gknd 1844 16 ) ) -RRB- cord-010119-t1x9gknd 1844 17 and and CC cord-010119-t1x9gknd 1844 18 low low JJ cord-010119-t1x9gknd 1844 19 A A NNP cord-010119-t1x9gknd 1844 20 - - HYPH cord-010119-t1x9gknd 1844 21 IPC IPC NNP cord-010119-t1x9gknd 1844 22 ( ( -LRB- cord-010119-t1x9gknd 1844 23 mean mean VB cord-010119-t1x9gknd 1844 24 1.5 1.5 CD cord-010119-t1x9gknd 1844 25 x x SYM cord-010119-t1x9gknd 1844 26 10 10 CD cord-010119-t1x9gknd 1844 27 9 9 CD cord-010119-t1x9gknd 1844 28 /L /l CD cord-010119-t1x9gknd 1844 29 , , , cord-010119-t1x9gknd 1844 30 range range VBP cord-010119-t1x9gknd 1844 31 0.5 0.5 CD cord-010119-t1x9gknd 1844 32 -3.6 -3.6 CD cord-010119-t1x9gknd 1844 33 x x SYM cord-010119-t1x9gknd 1844 34 10 10 CD cord-010119-t1x9gknd 1844 35 9 9 CD cord-010119-t1x9gknd 1844 36 /L /l CD cord-010119-t1x9gknd 1844 37 ) ) -RRB- cord-010119-t1x9gknd 1844 38 . . . cord-010119-t1x9gknd 1845 1 Patients patient NNS cord-010119-t1x9gknd 1845 2 were be VBD cord-010119-t1x9gknd 1845 3 initiated initiate VBN cord-010119-t1x9gknd 1845 4 on on IN cord-010119-t1x9gknd 1845 5 daily daily JJ cord-010119-t1x9gknd 1845 6 TPE TPE NNP cord-010119-t1x9gknd 1845 7 and and CC cord-010119-t1x9gknd 1845 8 prednisone prednisone NN cord-010119-t1x9gknd 1845 9 ; ; : cord-010119-t1x9gknd 1845 10 additional additional JJ cord-010119-t1x9gknd 1845 11 immunosuppression immunosuppression NN cord-010119-t1x9gknd 1845 12 during during IN cord-010119-t1x9gknd 1845 13 hospital hospital NN cord-010119-t1x9gknd 1845 14 stay stay NN cord-010119-t1x9gknd 1845 15 for for IN cord-010119-t1x9gknd 1845 16 cohort cohort NN cord-010119-t1x9gknd 1845 17 consisted consist VBD cord-010119-t1x9gknd 1845 18 of of IN cord-010119-t1x9gknd 1845 19 rituximab rituximab NN cord-010119-t1x9gknd 1845 20 375 375 CD cord-010119-t1x9gknd 1845 21 mg mg NNP cord-010119-t1x9gknd 1845 22 / / SYM cord-010119-t1x9gknd 1845 23 m m NNP cord-010119-t1x9gknd 1845 24 2 2 CD cord-010119-t1x9gknd 1845 25 ( ( -LRB- cord-010119-t1x9gknd 1845 26 4 4 CD cord-010119-t1x9gknd 1845 27 patients patient NNS cord-010119-t1x9gknd 1845 28 ) ) -RRB- cord-010119-t1x9gknd 1845 29 and and CC cord-010119-t1x9gknd 1845 30 cyclophosphamide cyclophosphamide RB cord-010119-t1x9gknd 1845 31 400 400 CD cord-010119-t1x9gknd 1845 32 mg mg NNP cord-010119-t1x9gknd 1845 33 / / SYM cord-010119-t1x9gknd 1845 34 m m NN cord-010119-t1x9gknd 1845 35 2 2 CD cord-010119-t1x9gknd 1845 36 ( ( -LRB- cord-010119-t1x9gknd 1845 37 one one CD cord-010119-t1x9gknd 1845 38 patient patient NN cord-010119-t1x9gknd 1845 39 ) ) -RRB- cord-010119-t1x9gknd 1845 40 . . . cord-010119-t1x9gknd 1846 1 TPE TPE NNP cord-010119-t1x9gknd 1846 2 continued continue VBD cord-010119-t1x9gknd 1846 3 until until IN cord-010119-t1x9gknd 1846 4 platelet platelet NN cord-010119-t1x9gknd 1846 5 count count NN cord-010119-t1x9gknd 1846 6 reached reach VBD cord-010119-t1x9gknd 1846 7 150 150 CD cord-010119-t1x9gknd 1846 8 x x SYM cord-010119-t1x9gknd 1846 9 10 10 CD cord-010119-t1x9gknd 1846 10 9 9 CD cord-010119-t1x9gknd 1846 11 /L /L . cord-010119-t1x9gknd 1846 12 for for IN cord-010119-t1x9gknd 1846 13 at at RB cord-010119-t1x9gknd 1846 14 least least RBS cord-010119-t1x9gknd 1846 15 two two CD cord-010119-t1x9gknd 1846 16 consecutive consecutive JJ cord-010119-t1x9gknd 1846 17 days day NNS cord-010119-t1x9gknd 1846 18 . . . cord-010119-t1x9gknd 1847 1 Immature immature JJ cord-010119-t1x9gknd 1847 2 platelet platelet NN cord-010119-t1x9gknd 1847 3 fraction fraction NN cord-010119-t1x9gknd 1847 4 ( ( -LRB- cord-010119-t1x9gknd 1847 5 % % NN cord-010119-t1x9gknd 1847 6 -IPF -ipf CD cord-010119-t1x9gknd 1847 7 ) ) -RRB- cord-010119-t1x9gknd 1847 8 and and CC cord-010119-t1x9gknd 1847 9 A A NNP cord-010119-t1x9gknd 1847 10 - - HYPH cord-010119-t1x9gknd 1847 11 IPC IPC NNP cord-010119-t1x9gknd 1847 12 ( ( -LRB- cord-010119-t1x9gknd 1847 13 % % NN cord-010119-t1x9gknd 1847 14 -IPF -ipf SYM cord-010119-t1x9gknd 1847 15 x x SYM cord-010119-t1x9gknd 1847 16 platelet platelet NN cord-010119-t1x9gknd 1847 17 count count NN cord-010119-t1x9gknd 1847 18 ) ) -RRB- cord-010119-t1x9gknd 1847 19 were be VBD cord-010119-t1x9gknd 1847 20 obtained obtain VBN cord-010119-t1x9gknd 1847 21 with with IN cord-010119-t1x9gknd 1847 22 daily daily JJ cord-010119-t1x9gknd 1847 23 pre pre JJ cord-010119-t1x9gknd 1847 24 - - NNP cord-010119-t1x9gknd 1847 25 TPE TPE NNP cord-010119-t1x9gknd 1847 26 CBC CBC NNP cord-010119-t1x9gknd 1847 27 . . . cord-010119-t1x9gknd 1848 1 A a LS cord-010119-t1x9gknd 1848 2 - - HYPH cord-010119-t1x9gknd 1848 3 IPC IPC NNP cord-010119-t1x9gknd 1848 4 ratio ratio NN cord-010119-t1x9gknd 1848 5 was be VBD cord-010119-t1x9gknd 1848 6 calculated calculate VBN cord-010119-t1x9gknd 1848 7 from from IN cord-010119-t1x9gknd 1848 8 baseline baseline NN cord-010119-t1x9gknd 1848 9 . . . cord-010119-t1x9gknd 1849 1 Results/ Results/ . cord-010119-t1x9gknd 1850 1 Finding finding NN cord-010119-t1x9gknd 1850 2 : : : cord-010119-t1x9gknd 1851 1 Patients patient NNS cord-010119-t1x9gknd 1851 2 responded respond VBD cord-010119-t1x9gknd 1851 3 rapidly rapidly RB cord-010119-t1x9gknd 1851 4 to to IN cord-010119-t1x9gknd 1851 5 daily daily JJ cord-010119-t1x9gknd 1851 6 TPE TPE NNP cord-010119-t1x9gknd 1851 7 ( ( -LRB- cord-010119-t1x9gknd 1851 8 mean mean NN cord-010119-t1x9gknd 1851 9 of of IN cord-010119-t1x9gknd 1851 10 2.4 2.4 CD cord-010119-t1x9gknd 1851 11 days day NNS cord-010119-t1x9gknd 1851 12 [ [ -LRB- cord-010119-t1x9gknd 1851 13 range range NN cord-010119-t1x9gknd 1851 14 1 1 CD cord-010119-t1x9gknd 1851 15 - - SYM cord-010119-t1x9gknd 1851 16 4 4 CD cord-010119-t1x9gknd 1851 17 days day NNS cord-010119-t1x9gknd 1851 18 ] ] -RRB- cord-010119-t1x9gknd 1851 19 ) ) -RRB- cord-010119-t1x9gknd 1851 20 when when WRB cord-010119-t1x9gknd 1851 21 they -PRON- PRP cord-010119-t1x9gknd 1851 22 achieved achieve VBD cord-010119-t1x9gknd 1851 23 a a DT cord-010119-t1x9gknd 1851 24 three three CD cord-010119-t1x9gknd 1851 25 - - HYPH cord-010119-t1x9gknd 1851 26 fold fold JJ cord-010119-t1x9gknd 1851 27 increase increase NN cord-010119-t1x9gknd 1851 28 in in IN cord-010119-t1x9gknd 1851 29 A A NNP cord-010119-t1x9gknd 1851 30 - - HYPH cord-010119-t1x9gknd 1851 31 IPC IPC NNP cord-010119-t1x9gknd 1851 32 from from IN cord-010119-t1x9gknd 1851 33 baseline baseline JJ cord-010119-t1x9gknd 1851 34 ( ( -LRB- cord-010119-t1x9gknd 1851 35 mean mean VB cord-010119-t1x9gknd 1851 36 11.1 11.1 CD cord-010119-t1x9gknd 1851 37 x x SYM cord-010119-t1x9gknd 1851 38 10 10 CD cord-010119-t1x9gknd 1851 39 9 9 CD cord-010119-t1x9gknd 1851 40 /L /l CD cord-010119-t1x9gknd 1851 41 , , , cord-010119-t1x9gknd 1851 42 range range VBP cord-010119-t1x9gknd 1851 43 2.2 2.2 CD cord-010119-t1x9gknd 1852 1 -25.3 -25.3 : cord-010119-t1x9gknd 1853 1 x x SYM cord-010119-t1x9gknd 1853 2 10 10 CD cord-010119-t1x9gknd 1853 3 9 9 CD cord-010119-t1x9gknd 1853 4 /L /l CD cord-010119-t1x9gknd 1853 5 ) ) -RRB- cord-010119-t1x9gknd 1853 6 and and CC cord-010119-t1x9gknd 1853 7 a a DT cord-010119-t1x9gknd 1853 8 rapid rapid JJ cord-010119-t1x9gknd 1853 9 improvement improvement NN cord-010119-t1x9gknd 1853 10 in in IN cord-010119-t1x9gknd 1853 11 platelet platelet NN cord-010119-t1x9gknd 1853 12 count count NN cord-010119-t1x9gknd 1853 13 . . . cord-010119-t1x9gknd 1854 1 However however RB cord-010119-t1x9gknd 1854 2 , , , cord-010119-t1x9gknd 1854 3 this this DT cord-010119-t1x9gknd 1854 4 improvement improvement NN cord-010119-t1x9gknd 1854 5 in in IN cord-010119-t1x9gknd 1854 6 platelet platelet NN cord-010119-t1x9gknd 1854 7 count count NN cord-010119-t1x9gknd 1854 8 was be VBD cord-010119-t1x9gknd 1854 9 not not RB cord-010119-t1x9gknd 1854 10 accompanied accompany VBN cord-010119-t1x9gknd 1854 11 by by IN cord-010119-t1x9gknd 1854 12 expected expect VBN cord-010119-t1x9gknd 1854 13 decreases decrease NNS cord-010119-t1x9gknd 1854 14 in in IN cord-010119-t1x9gknd 1854 15 A A NNP cord-010119-t1x9gknd 1854 16 - - HYPH cord-010119-t1x9gknd 1854 17 IPC IPC NNP cord-010119-t1x9gknd 1854 18 , , , cord-010119-t1x9gknd 1854 19 suggestive suggestive JJ cord-010119-t1x9gknd 1854 20 of of IN cord-010119-t1x9gknd 1854 21 recovery recovery NN cord-010119-t1x9gknd 1854 22 from from IN cord-010119-t1x9gknd 1854 23 disease disease NN cord-010119-t1x9gknd 1854 24 . . . cord-010119-t1x9gknd 1855 1 All all DT cord-010119-t1x9gknd 1855 2 patients patient NNS cord-010119-t1x9gknd 1855 3 experienced experience VBD cord-010119-t1x9gknd 1855 4 platelet platelet NN cord-010119-t1x9gknd 1855 5 ( ( -LRB- cord-010119-t1x9gknd 1855 6 mean mean VB cord-010119-t1x9gknd 1855 7 217.6 217.6 CD cord-010119-t1x9gknd 1856 1 x x SYM cord-010119-t1x9gknd 1856 2 10 10 CD cord-010119-t1x9gknd 1856 3 9 9 CD cord-010119-t1x9gknd 1856 4 /L /l CD cord-010119-t1x9gknd 1856 5 , , , cord-010119-t1x9gknd 1856 6 range range VBP cord-010119-t1x9gknd 1856 7 200 200 CD cord-010119-t1x9gknd 1857 1 -294 -294 JJ cord-010119-t1x9gknd 1858 1 x x SYM cord-010119-t1x9gknd 1858 2 10 10 CD cord-010119-t1x9gknd 1858 3 9 9 CD cord-010119-t1x9gknd 1858 4 /L /l CD cord-010119-t1x9gknd 1858 5 ) ) -RRB- cord-010119-t1x9gknd 1858 6 and and CC cord-010119-t1x9gknd 1858 7 A A NNP cord-010119-t1x9gknd 1858 8 - - HYPH cord-010119-t1x9gknd 1858 9 IPC IPC NNP cord-010119-t1x9gknd 1859 1 ( ( -LRB- cord-010119-t1x9gknd 1859 2 mean mean VB cord-010119-t1x9gknd 1860 1 19.4 19.4 CD cord-010119-t1x9gknd 1860 2 x x SYM cord-010119-t1x9gknd 1860 3 10 10 CD cord-010119-t1x9gknd 1860 4 9 9 CD cord-010119-t1x9gknd 1860 5 /L /l CD cord-010119-t1x9gknd 1860 6 , , , cord-010119-t1x9gknd 1860 7 range range VBP cord-010119-t1x9gknd 1860 8 13 13 CD cord-010119-t1x9gknd 1861 1 -28.5 -28.5 . cord-010119-t1x9gknd 1862 1 x x SYM cord-010119-t1x9gknd 1862 2 10 10 CD cord-010119-t1x9gknd 1862 3 9 9 CD cord-010119-t1x9gknd 1862 4 /L /L . cord-010119-t1x9gknd 1862 5 ) ) -RRB- cord-010119-t1x9gknd 1862 6 decreases decrease VBZ cord-010119-t1x9gknd 1862 7 that that WDT cord-010119-t1x9gknd 1862 8 occurred occur VBD cord-010119-t1x9gknd 1862 9 concurrently concurrently RB cord-010119-t1x9gknd 1862 10 while while IN cord-010119-t1x9gknd 1862 11 receiving receive VBG cord-010119-t1x9gknd 1862 12 daily daily JJ cord-010119-t1x9gknd 1862 13 TPE TPE NNP cord-010119-t1x9gknd 1863 1 so so IN cord-010119-t1x9gknd 1863 2 that that IN cord-010119-t1x9gknd 1863 3 after after IN cord-010119-t1x9gknd 1863 4 a a DT cord-010119-t1x9gknd 1863 5 mean mean NN cord-010119-t1x9gknd 1863 6 of of IN cord-010119-t1x9gknd 1863 7 11.6 11.6 CD cord-010119-t1x9gknd 1863 8 days day NNS cord-010119-t1x9gknd 1863 9 ( ( -LRB- cord-010119-t1x9gknd 1863 10 range range NNP cord-010119-t1x9gknd 1863 11 8 8 CD cord-010119-t1x9gknd 1863 12 - - SYM cord-010119-t1x9gknd 1863 13 14 14 CD cord-010119-t1x9gknd 1863 14 days day NNS cord-010119-t1x9gknd 1863 15 ) ) -RRB- cord-010119-t1x9gknd 1863 16 mean mean VBP cord-010119-t1x9gknd 1863 17 platelet platelet NN cord-010119-t1x9gknd 1863 18 count count NN cord-010119-t1x9gknd 1863 19 was be VBD cord-010119-t1x9gknd 1863 20 65.4 65.4 CD cord-010119-t1x9gknd 1863 21 x x SYM cord-010119-t1x9gknd 1863 22 10 10 CD cord-010119-t1x9gknd 1863 23 9 9 CD cord-010119-t1x9gknd 1863 24 /L /L . cord-010119-t1x9gknd 1863 25 ( ( -LRB- cord-010119-t1x9gknd 1863 26 range range NN cord-010119-t1x9gknd 1863 27 14 14 CD cord-010119-t1x9gknd 1863 28 176 176 CD cord-010119-t1x9gknd 1863 29 x x SYM cord-010119-t1x9gknd 1863 30 10 10 CD cord-010119-t1x9gknd 1863 31 9 9 CD cord-010119-t1x9gknd 1863 32 /L /l CD cord-010119-t1x9gknd 1863 33 ) ) -RRB- cord-010119-t1x9gknd 1863 34 and and CC cord-010119-t1x9gknd 1863 35 mean mean VB cord-010119-t1x9gknd 1863 36 A A NNP cord-010119-t1x9gknd 1863 37 - - HYPH cord-010119-t1x9gknd 1863 38 IPC IPC NNP cord-010119-t1x9gknd 1863 39 3.2 3.2 CD cord-010119-t1x9gknd 1863 40 x x SYM cord-010119-t1x9gknd 1863 41 10 10 CD cord-010119-t1x9gknd 1863 42 9 9 CD cord-010119-t1x9gknd 1863 43 /L /L . cord-010119-t1x9gknd 1863 44 ( ( -LRB- cord-010119-t1x9gknd 1863 45 range range NN cord-010119-t1x9gknd 1863 46 0.7 0.7 CD cord-010119-t1x9gknd 1863 47 -6.6 -6.6 CD cord-010119-t1x9gknd 1863 48 x x SYM cord-010119-t1x9gknd 1863 49 10 10 CD cord-010119-t1x9gknd 1863 50 9 9 CD cord-010119-t1x9gknd 1863 51 /L /l CD cord-010119-t1x9gknd 1863 52 ) ) -RRB- cord-010119-t1x9gknd 1863 53 . . . cord-010119-t1x9gknd 1864 1 Patients patient NNS cord-010119-t1x9gknd 1864 2 were be VBD cord-010119-t1x9gknd 1864 3 initiated initiate VBN cord-010119-t1x9gknd 1864 4 in in IN cord-010119-t1x9gknd 1864 5 either either CC cord-010119-t1x9gknd 1864 6 rituximab rituximab VBN cord-010119-t1x9gknd 1864 7 or or CC cord-010119-t1x9gknd 1864 8 cyclophosphamide cyclophosphamide NN cord-010119-t1x9gknd 1864 9 therapy therapy NN cord-010119-t1x9gknd 1864 10 in in IN cord-010119-t1x9gknd 1864 11 conjunction conjunction NN cord-010119-t1x9gknd 1864 12 with with IN cord-010119-t1x9gknd 1864 13 TPE TPE NNP cord-010119-t1x9gknd 1864 14 after after IN cord-010119-t1x9gknd 1864 15 a a DT cord-010119-t1x9gknd 1864 16 mean mean NN cord-010119-t1x9gknd 1864 17 of of IN cord-010119-t1x9gknd 1864 18 20.8 20.8 CD cord-010119-t1x9gknd 1864 19 days day NNS cord-010119-t1x9gknd 1864 20 of of IN cord-010119-t1x9gknd 1864 21 A A NNP cord-010119-t1x9gknd 1864 22 - - HYPH cord-010119-t1x9gknd 1864 23 IPC IPC NNP cord-010119-t1x9gknd 1864 24 and and CC cord-010119-t1x9gknd 1864 25 platelet platelet NN cord-010119-t1x9gknd 1864 26 count count NN cord-010119-t1x9gknd 1864 27 instability instability NN cord-010119-t1x9gknd 1864 28 . . . cord-010119-t1x9gknd 1865 1 A a LS cord-010119-t1x9gknd 1865 2 - - HYPH cord-010119-t1x9gknd 1865 3 IPC IPC NNP cord-010119-t1x9gknd 1865 4 trended trend VBD cord-010119-t1x9gknd 1865 5 to to IN cord-010119-t1x9gknd 1865 6 levels level NNS cord-010119-t1x9gknd 1865 7 indicative indicative JJ cord-010119-t1x9gknd 1865 8 of of IN cord-010119-t1x9gknd 1865 9 restoration restoration NN cord-010119-t1x9gknd 1865 10 of of IN cord-010119-t1x9gknd 1865 11 a a DT cord-010119-t1x9gknd 1865 12 negative negative JJ cord-010119-t1x9gknd 1865 13 feedback feedback NN cord-010119-t1x9gknd 1865 14 after after IN cord-010119-t1x9gknd 1865 15 this this DT cord-010119-t1x9gknd 1865 16 time time NN cord-010119-t1x9gknd 1865 17 . . . cord-010119-t1x9gknd 1866 1 Conclusion conclusion NN cord-010119-t1x9gknd 1866 2 : : : cord-010119-t1x9gknd 1867 1 Rapid rapid JJ cord-010119-t1x9gknd 1867 2 decreases decrease NNS cord-010119-t1x9gknd 1867 3 in in IN cord-010119-t1x9gknd 1867 4 platelet platelet NN cord-010119-t1x9gknd 1867 5 counts count NNS cord-010119-t1x9gknd 1867 6 after after IN cord-010119-t1x9gknd 1867 7 a a DT cord-010119-t1x9gknd 1867 8 good good JJ cord-010119-t1x9gknd 1867 9 response response NN cord-010119-t1x9gknd 1867 10 in in IN cord-010119-t1x9gknd 1867 11 TTP TTP NNP cord-010119-t1x9gknd 1867 12 patients patient NNS cord-010119-t1x9gknd 1867 13 may may MD cord-010119-t1x9gknd 1867 14 raise raise VB cord-010119-t1x9gknd 1867 15 suspicion suspicion NN cord-010119-t1x9gknd 1867 16 for for IN cord-010119-t1x9gknd 1867 17 presence presence NN cord-010119-t1x9gknd 1867 18 of of IN cord-010119-t1x9gknd 1867 19 high high JJ cord-010119-t1x9gknd 1867 20 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 1867 21 inhibitor inhibitor NN cord-010119-t1x9gknd 1867 22 . . . cord-010119-t1x9gknd 1868 1 Patients patient NNS cord-010119-t1x9gknd 1868 2 with with IN cord-010119-t1x9gknd 1868 3 a a DT cord-010119-t1x9gknd 1868 4 high high JJ cord-010119-t1x9gknd 1868 5 inhibitor inhibitor NN cord-010119-t1x9gknd 1868 6 have have VBP cord-010119-t1x9gknd 1868 7 similar similar JJ cord-010119-t1x9gknd 1868 8 A A NNP cord-010119-t1x9gknd 1868 9 - - HYPH cord-010119-t1x9gknd 1868 10 IPC IPC NNP cord-010119-t1x9gknd 1868 11 dynamics dynamic NNS cord-010119-t1x9gknd 1868 12 during during IN cord-010119-t1x9gknd 1868 13 which which WDT cord-010119-t1x9gknd 1868 14 initial initial JJ cord-010119-t1x9gknd 1868 15 high high JJ cord-010119-t1x9gknd 1868 16 A A NNP cord-010119-t1x9gknd 1868 17 - - HYPH cord-010119-t1x9gknd 1868 18 IPC IPC NNP cord-010119-t1x9gknd 1868 19 production production NN cord-010119-t1x9gknd 1868 20 is be VBZ cord-010119-t1x9gknd 1868 21 followed follow VBN cord-010119-t1x9gknd 1868 22 by by IN cord-010119-t1x9gknd 1868 23 unexpected unexpected JJ cord-010119-t1x9gknd 1868 24 decreases decrease NNS cord-010119-t1x9gknd 1868 25 in in IN cord-010119-t1x9gknd 1868 26 A A NNP cord-010119-t1x9gknd 1868 27 - - HYPH cord-010119-t1x9gknd 1868 28 IPC IPC NNP cord-010119-t1x9gknd 1868 29 concurrent concurrent NN cord-010119-t1x9gknd 1868 30 with with IN cord-010119-t1x9gknd 1868 31 platelet platelet NN cord-010119-t1x9gknd 1868 32 counts count NNS cord-010119-t1x9gknd 1868 33 . . . cord-010119-t1x9gknd 1869 1 Recovery recovery NN cord-010119-t1x9gknd 1869 2 occurs occur VBZ cord-010119-t1x9gknd 1869 3 once once RB cord-010119-t1x9gknd 1869 4 negative negative JJ cord-010119-t1x9gknd 1869 5 feedback feedback NN cord-010119-t1x9gknd 1869 6 between between IN cord-010119-t1x9gknd 1869 7 platelet platelet NN cord-010119-t1x9gknd 1869 8 and and CC cord-010119-t1x9gknd 1869 9 A A NNP cord-010119-t1x9gknd 1869 10 - - HYPH cord-010119-t1x9gknd 1869 11 IPC IPC NNP cord-010119-t1x9gknd 1869 12 production production NN cord-010119-t1x9gknd 1869 13 is be VBZ cord-010119-t1x9gknd 1869 14 re re VBN cord-010119-t1x9gknd 1869 15 - - VBN cord-010119-t1x9gknd 1869 16 established establish VBN cord-010119-t1x9gknd 1869 17 . . . cord-010119-t1x9gknd 1870 1 Patients patient NNS cord-010119-t1x9gknd 1870 2 with with IN cord-010119-t1x9gknd 1870 3 a a DT cord-010119-t1x9gknd 1870 4 high high JJ cord-010119-t1x9gknd 1870 5 inhibitor inhibitor NN cord-010119-t1x9gknd 1870 6 may may MD cord-010119-t1x9gknd 1870 7 represent represent VB cord-010119-t1x9gknd 1870 8 a a DT cord-010119-t1x9gknd 1870 9 distinct distinct JJ cord-010119-t1x9gknd 1870 10 subset subset NN cord-010119-t1x9gknd 1870 11 of of IN cord-010119-t1x9gknd 1870 12 TTP TTP NNP cord-010119-t1x9gknd 1870 13 as as IN cord-010119-t1x9gknd 1870 14 suggested suggest VBN cord-010119-t1x9gknd 1870 15 by by IN cord-010119-t1x9gknd 1870 16 A A NNP cord-010119-t1x9gknd 1870 17 - - HYPH cord-010119-t1x9gknd 1870 18 IPC IPC NNP cord-010119-t1x9gknd 1870 19 responses response NNS cord-010119-t1x9gknd 1870 20 . . . cord-010119-t1x9gknd 1871 1 Benchmarking benchmarke VBG cord-010119-t1x9gknd 1871 2 the the DT cord-010119-t1x9gknd 1871 3 Centralized Centralized NNP cord-010119-t1x9gknd 1871 4 Urgent Urgent NNP cord-010119-t1x9gknd 1871 5 Plasma Plasma NNP cord-010119-t1x9gknd 1871 6 Exchange Exchange NNP cord-010119-t1x9gknd 1871 7 Service Service NNP cord-010119-t1x9gknd 1871 8 for for IN cord-010119-t1x9gknd 1871 9 Patients Patients NNP cord-010119-t1x9gknd 1871 10 Admitted admit VBN cord-010119-t1x9gknd 1871 11 with with IN cord-010119-t1x9gknd 1871 12 a a DT cord-010119-t1x9gknd 1871 13 Diagnosis diagnosis NN cord-010119-t1x9gknd 1871 14 of of IN cord-010119-t1x9gknd 1871 15 Thrombotic Thrombotic NNP cord-010119-t1x9gknd 1871 16 Thrombocytopenic Thrombocytopenic NNP cord-010119-t1x9gknd 1871 17 Purpura Purpura NNP cord-010119-t1x9gknd 1871 18 at at IN cord-010119-t1x9gknd 1871 19 a a DT cord-010119-t1x9gknd 1871 20 Multi Multi NNP cord-010119-t1x9gknd 1871 21 - - HYPH cord-010119-t1x9gknd 1871 22 Hospital Hospital NNP cord-010119-t1x9gknd 1871 23 Healthcare Healthcare NNP cord-010119-t1x9gknd 1871 24 System System NNP cord-010119-t1x9gknd 1871 25 Jansen Jansen NNP cord-010119-t1x9gknd 1871 26 N N NNP cord-010119-t1x9gknd 1871 27 Seheult Seheult NNP cord-010119-t1x9gknd 1871 28 * * NFP cord-010119-t1x9gknd 1871 29 1 1 CD cord-010119-t1x9gknd 1871 30 , , , cord-010119-t1x9gknd 1871 31 Michelle Michelle NNP cord-010119-t1x9gknd 1871 32 N N NNP cord-010119-t1x9gknd 1871 33 Stram Stram NNP cord-010119-t1x9gknd 1871 34 1 1 CD cord-010119-t1x9gknd 1871 35 , , , cord-010119-t1x9gknd 1871 36 Joan Joan NNP cord-010119-t1x9gknd 1871 37 Sevcik Sevcik NNP cord-010119-t1x9gknd 1871 38 2 2 CD cord-010119-t1x9gknd 1871 39 , , , cord-010119-t1x9gknd 1871 40 Alesia Alesia NNP cord-010119-t1x9gknd 1871 41 Kaplan Kaplan NNP cord-010119-t1x9gknd 1871 42 2,3 2,3 CD cord-010119-t1x9gknd 1871 43 and and CC cord-010119-t1x9gknd 1871 44 Joseph Joseph NNP cord-010119-t1x9gknd 1871 45 E. E. NNP cord-010119-t1x9gknd 1871 46 Kiss Kiss NNP cord-010119-t1x9gknd 1871 47 2,3 2,3 CD cord-010119-t1x9gknd 1871 48 . . . cord-010119-t1x9gknd 1872 1 1 1 LS cord-010119-t1x9gknd 1872 2 Department Department NNP cord-010119-t1x9gknd 1872 3 of of IN cord-010119-t1x9gknd 1872 4 Pathology Pathology NNP cord-010119-t1x9gknd 1872 5 , , , cord-010119-t1x9gknd 1872 6 University University NNP cord-010119-t1x9gknd 1872 7 of of IN cord-010119-t1x9gknd 1872 8 Pittsburgh Pittsburgh NNP cord-010119-t1x9gknd 1872 9 Medical Medical NNP cord-010119-t1x9gknd 1872 10 Center Center NNP cord-010119-t1x9gknd 1872 11 , , , cord-010119-t1x9gknd 1872 12 2 2 CD cord-010119-t1x9gknd 1872 13 Blood Blood NNP cord-010119-t1x9gknd 1872 14 Systems Systems NNPS cord-010119-t1x9gknd 1872 15 Inc. Inc. NNP cord-010119-t1x9gknd 1872 16 , , , cord-010119-t1x9gknd 1872 17 3 3 CD cord-010119-t1x9gknd 1872 18 University University NNP cord-010119-t1x9gknd 1872 19 of of IN cord-010119-t1x9gknd 1872 20 Pittsburgh Pittsburgh NNP cord-010119-t1x9gknd 1872 21 Background Background NNP cord-010119-t1x9gknd 1872 22 / / SYM cord-010119-t1x9gknd 1872 23 Case Case NNP cord-010119-t1x9gknd 1872 24 Studies Studies NNPS cord-010119-t1x9gknd 1872 25 : : : cord-010119-t1x9gknd 1873 1 Consensus consensus NN cord-010119-t1x9gknd 1873 2 guidelines guideline NNS cord-010119-t1x9gknd 1873 3 recommend recommend VBP cord-010119-t1x9gknd 1873 4 that that IN cord-010119-t1x9gknd 1873 5 therapeutic therapeutic JJ cord-010119-t1x9gknd 1873 6 plasma plasma NN cord-010119-t1x9gknd 1873 7 exchange exchange NN cord-010119-t1x9gknd 1873 8 ( ( -LRB- cord-010119-t1x9gknd 1873 9 TPE TPE NNP cord-010119-t1x9gknd 1873 10 ) ) -RRB- cord-010119-t1x9gknd 1873 11 must must MD cord-010119-t1x9gknd 1873 12 be be VB cord-010119-t1x9gknd 1873 13 started start VBN cord-010119-t1x9gknd 1873 14 as as RB cord-010119-t1x9gknd 1873 15 early early RB cord-010119-t1x9gknd 1873 16 as as IN cord-010119-t1x9gknd 1873 17 possible possible JJ cord-010119-t1x9gknd 1873 18 and and CC cord-010119-t1x9gknd 1873 19 within within IN cord-010119-t1x9gknd 1873 20 4 4 CD cord-010119-t1x9gknd 1873 21 - - SYM cord-010119-t1x9gknd 1873 22 8 8 CD cord-010119-t1x9gknd 1873 23 hours hour NNS cord-010119-t1x9gknd 1873 24 after after IN cord-010119-t1x9gknd 1873 25 the the DT cord-010119-t1x9gknd 1873 26 diagnosis diagnosis NN cord-010119-t1x9gknd 1873 27 of of IN cord-010119-t1x9gknd 1873 28 thrombotic thrombotic JJ cord-010119-t1x9gknd 1873 29 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 1873 30 purpura purpura NN cord-010119-t1x9gknd 1873 31 ( ( -LRB- cord-010119-t1x9gknd 1873 32 TTP TTP NNP cord-010119-t1x9gknd 1873 33 ) ) -RRB- cord-010119-t1x9gknd 1873 34 has have VBZ cord-010119-t1x9gknd 1873 35 been be VBN cord-010119-t1x9gknd 1873 36 made make VBN cord-010119-t1x9gknd 1873 37 ; ; : cord-010119-t1x9gknd 1873 38 however however RB cord-010119-t1x9gknd 1873 39 , , , cord-010119-t1x9gknd 1873 40 there there EX cord-010119-t1x9gknd 1873 41 are be VBP cord-010119-t1x9gknd 1873 42 limited limited JJ cord-010119-t1x9gknd 1873 43 data datum NNS cord-010119-t1x9gknd 1873 44 documenting document VBG cord-010119-t1x9gknd 1873 45 actual actual JJ cord-010119-t1x9gknd 1873 46 practice practice NN cord-010119-t1x9gknd 1873 47 . . . cord-010119-t1x9gknd 1874 1 There there EX cord-010119-t1x9gknd 1874 2 are be VBP cord-010119-t1x9gknd 1874 3 several several JJ cord-010119-t1x9gknd 1874 4 operational operational JJ cord-010119-t1x9gknd 1874 5 facets facet NNS cord-010119-t1x9gknd 1874 6 of of IN cord-010119-t1x9gknd 1874 7 delivering deliver VBG cord-010119-t1x9gknd 1874 8 a a DT cord-010119-t1x9gknd 1874 9 centralized centralized JJ cord-010119-t1x9gknd 1874 10 urgent urgent JJ cord-010119-t1x9gknd 1874 11 TPE TPE NNP cord-010119-t1x9gknd 1874 12 program program NN cord-010119-t1x9gknd 1874 13 in in IN cord-010119-t1x9gknd 1874 14 a a DT cord-010119-t1x9gknd 1874 15 multi multi JJ cord-010119-t1x9gknd 1874 16 - - JJ cord-010119-t1x9gknd 1874 17 hospital hospital JJ cord-010119-t1x9gknd 1874 18 healthcare healthcare NN cord-010119-t1x9gknd 1874 19 system system NN cord-010119-t1x9gknd 1874 20 , , , cord-010119-t1x9gknd 1874 21 including include VBG cord-010119-t1x9gknd 1874 22 : : : cord-010119-t1x9gknd 1874 23 central central JJ cord-010119-t1x9gknd 1874 24 venous venous NN cord-010119-t1x9gknd 1874 25 ( ( -LRB- cord-010119-t1x9gknd 1874 26 CV cv NN cord-010119-t1x9gknd 1874 27 ) ) -RRB- cord-010119-t1x9gknd 1874 28 access access NN cord-010119-t1x9gknd 1874 29 , , , cord-010119-t1x9gknd 1874 30 ordering ordering NN cord-010119-t1x9gknd 1874 31 , , , cord-010119-t1x9gknd 1874 32 release release NN cord-010119-t1x9gknd 1874 33 and and CC cord-010119-t1x9gknd 1874 34 delivery delivery NN cord-010119-t1x9gknd 1874 35 of of IN cord-010119-t1x9gknd 1874 36 thawed thawed JJ cord-010119-t1x9gknd 1874 37 plasma plasma NN cord-010119-t1x9gknd 1874 38 , , , cord-010119-t1x9gknd 1874 39 and and CC cord-010119-t1x9gknd 1874 40 transportation transportation NN cord-010119-t1x9gknd 1874 41 of of IN cord-010119-t1x9gknd 1874 42 personnel personnel NNS cord-010119-t1x9gknd 1874 43 and and CC cord-010119-t1x9gknd 1874 44 equipment equipment NN cord-010119-t1x9gknd 1874 45 to to TO cord-010119-t1x9gknd 1874 46 perform perform VB cord-010119-t1x9gknd 1874 47 the the DT cord-010119-t1x9gknd 1874 48 procedure procedure NN cord-010119-t1x9gknd 1874 49 . . . cord-010119-t1x9gknd 1875 1 This this DT cord-010119-t1x9gknd 1875 2 study study NN cord-010119-t1x9gknd 1875 3 analyzes analyze VBZ cord-010119-t1x9gknd 1875 4 the the DT cord-010119-t1x9gknd 1875 5 time time NN cord-010119-t1x9gknd 1875 6 elapsed elapse VBN cord-010119-t1x9gknd 1875 7 between between IN cord-010119-t1x9gknd 1875 8 major major JJ cord-010119-t1x9gknd 1875 9 steps step NNS cord-010119-t1x9gknd 1875 10 from from IN cord-010119-t1x9gknd 1875 11 diagnosis diagnosis NN cord-010119-t1x9gknd 1875 12 to to IN cord-010119-t1x9gknd 1875 13 initiation initiation NN cord-010119-t1x9gknd 1875 14 of of IN cord-010119-t1x9gknd 1875 15 TPE TPE NNP cord-010119-t1x9gknd 1875 16 in in IN cord-010119-t1x9gknd 1875 17 patients patient NNS cord-010119-t1x9gknd 1875 18 admitted admit VBN cord-010119-t1x9gknd 1875 19 with with IN cord-010119-t1x9gknd 1875 20 TTP TTP NNP cord-010119-t1x9gknd 1875 21 . . . cord-010119-t1x9gknd 1876 1 Study Study NNP cord-010119-t1x9gknd 1876 2 Design Design NNP cord-010119-t1x9gknd 1876 3 / / SYM cord-010119-t1x9gknd 1876 4 Method method NN cord-010119-t1x9gknd 1876 5 : : : cord-010119-t1x9gknd 1877 1 A a DT cord-010119-t1x9gknd 1877 2 retrospective retrospective JJ cord-010119-t1x9gknd 1877 3 review review NN cord-010119-t1x9gknd 1877 4 of of IN cord-010119-t1x9gknd 1877 5 the the DT cord-010119-t1x9gknd 1877 6 electronic electronic JJ cord-010119-t1x9gknd 1877 7 medical medical JJ cord-010119-t1x9gknd 1877 8 record record NN cord-010119-t1x9gknd 1877 9 and and CC cord-010119-t1x9gknd 1877 10 laboratory laboratory NN cord-010119-t1x9gknd 1877 11 information information NN cord-010119-t1x9gknd 1877 12 systems system NNS cord-010119-t1x9gknd 1877 13 from from IN cord-010119-t1x9gknd 1877 14 January January NNP cord-010119-t1x9gknd 1877 15 1 1 CD cord-010119-t1x9gknd 1877 16 , , , cord-010119-t1x9gknd 1877 17 2013 2013 CD cord-010119-t1x9gknd 1877 18 to to IN cord-010119-t1x9gknd 1877 19 November November NNP cord-010119-t1x9gknd 1877 20 1 1 CD cord-010119-t1x9gknd 1877 21 , , , cord-010119-t1x9gknd 1877 22 2016 2016 CD cord-010119-t1x9gknd 1877 23 was be VBD cord-010119-t1x9gknd 1877 24 conducted conduct VBN cord-010119-t1x9gknd 1877 25 to to TO cord-010119-t1x9gknd 1877 26 identify identify VB cord-010119-t1x9gknd 1877 27 all all DT cord-010119-t1x9gknd 1877 28 TTP TTP NNP cord-010119-t1x9gknd 1877 29 patients patient NNS cord-010119-t1x9gknd 1877 30 undergoing undergo VBG cord-010119-t1x9gknd 1877 31 urgent urgent JJ cord-010119-t1x9gknd 1877 32 TPE tpe NN cord-010119-t1x9gknd 1877 33 . . . cord-010119-t1x9gknd 1878 1 Demographics demographic NNS cord-010119-t1x9gknd 1878 2 , , , cord-010119-t1x9gknd 1878 3 comorbidities comorbiditie NNS cord-010119-t1x9gknd 1878 4 , , , cord-010119-t1x9gknd 1878 5 and and CC cord-010119-t1x9gknd 1878 6 other other JJ cord-010119-t1x9gknd 1878 7 pertinent pertinent JJ cord-010119-t1x9gknd 1878 8 laboratory laboratory NN cord-010119-t1x9gknd 1878 9 tests test NNS cord-010119-t1x9gknd 1878 10 ( ( -LRB- cord-010119-t1x9gknd 1878 11 such such JJ cord-010119-t1x9gknd 1878 12 as as IN cord-010119-t1x9gknd 1878 13 ADAMTS-13 adamts-13 DT cord-010119-t1x9gknd 1878 14 activity activity NN cord-010119-t1x9gknd 1878 15 levels level NNS cord-010119-t1x9gknd 1878 16 , , , cord-010119-t1x9gknd 1878 17 complete complete JJ cord-010119-t1x9gknd 1878 18 blood blood NN cord-010119-t1x9gknd 1878 19 count count NN cord-010119-t1x9gknd 1878 20 , , , cord-010119-t1x9gknd 1878 21 biochemical biochemical JJ cord-010119-t1x9gknd 1878 22 markers marker NNS cord-010119-t1x9gknd 1878 23 of of IN cord-010119-t1x9gknd 1878 24 hemolysis hemolysis NN cord-010119-t1x9gknd 1878 25 and and CC cord-010119-t1x9gknd 1878 26 coagulation coagulation NN cord-010119-t1x9gknd 1878 27 studies study NNS cord-010119-t1x9gknd 1878 28 ) ) -RRB- cord-010119-t1x9gknd 1878 29 were be VBD cord-010119-t1x9gknd 1878 30 reviewed review VBN cord-010119-t1x9gknd 1878 31 on on IN cord-010119-t1x9gknd 1878 32 all all DT cord-010119-t1x9gknd 1878 33 identified identify VBN cord-010119-t1x9gknd 1878 34 patients patient NNS cord-010119-t1x9gknd 1878 35 . . . cord-010119-t1x9gknd 1879 1 Temporal temporal JJ cord-010119-t1x9gknd 1879 2 data datum NNS cord-010119-t1x9gknd 1879 3 for for IN cord-010119-t1x9gknd 1879 4 TPE TPE NNP cord-010119-t1x9gknd 1879 5 request request NN cord-010119-t1x9gknd 1879 6 , , , cord-010119-t1x9gknd 1879 7 CV cv NN cord-010119-t1x9gknd 1879 8 access access NN cord-010119-t1x9gknd 1879 9 placement placement NN cord-010119-t1x9gknd 1879 10 , , , cord-010119-t1x9gknd 1879 11 plasma plasma NN cord-010119-t1x9gknd 1879 12 product product NN cord-010119-t1x9gknd 1879 13 release release NN cord-010119-t1x9gknd 1879 14 ( ( -LRB- cord-010119-t1x9gknd 1879 15 which which WDT cord-010119-t1x9gknd 1879 16 usually usually RB cord-010119-t1x9gknd 1879 17 happens happen VBZ cord-010119-t1x9gknd 1879 18 after after IN cord-010119-t1x9gknd 1879 19 CV CV NNP cord-010119-t1x9gknd 1879 20 access access NN cord-010119-t1x9gknd 1879 21 ) ) -RRB- cord-010119-t1x9gknd 1879 22 , , , cord-010119-t1x9gknd 1879 23 arrival arrival NN cord-010119-t1x9gknd 1879 24 of of IN cord-010119-t1x9gknd 1879 25 TPE TPE NNP cord-010119-t1x9gknd 1879 26 team team NN cord-010119-t1x9gknd 1879 27 and and CC cord-010119-t1x9gknd 1879 28 initiation initiation NN cord-010119-t1x9gknd 1879 29 of of IN cord-010119-t1x9gknd 1879 30 the the DT cord-010119-t1x9gknd 1879 31 procedure procedure NN cord-010119-t1x9gknd 1879 32 were be VBD cord-010119-t1x9gknd 1879 33 extracted extract VBN cord-010119-t1x9gknd 1879 34 from from IN cord-010119-t1x9gknd 1879 35 procedure procedure NN cord-010119-t1x9gknd 1879 36 notes note NNS cord-010119-t1x9gknd 1879 37 and and CC cord-010119-t1x9gknd 1879 38 the the DT cord-010119-t1x9gknd 1879 39 blood blood NN cord-010119-t1x9gknd 1879 40 bank bank NN cord-010119-t1x9gknd 1879 41 information information NN cord-010119-t1x9gknd 1879 42 system system NN cord-010119-t1x9gknd 1879 43 . . . cord-010119-t1x9gknd 1880 1 Descriptive descriptive JJ cord-010119-t1x9gknd 1880 2 and and CC cord-010119-t1x9gknd 1880 3 summary summary NN cord-010119-t1x9gknd 1880 4 statistics statistic NNS cord-010119-t1x9gknd 1880 5 were be VBD cord-010119-t1x9gknd 1880 6 generated generate VBN cord-010119-t1x9gknd 1880 7 using use VBG cord-010119-t1x9gknd 1880 8 Stata Stata NNP cord-010119-t1x9gknd 1880 9 version version NN cord-010119-t1x9gknd 1880 10 14 14 CD cord-010119-t1x9gknd 1880 11 ( ( -LRB- cord-010119-t1x9gknd 1880 12 Statacorp Statacorp NNP cord-010119-t1x9gknd 1880 13 , , , cord-010119-t1x9gknd 1880 14 TX TX NNP cord-010119-t1x9gknd 1880 15 ) ) -RRB- cord-010119-t1x9gknd 1880 16 . . . cord-010119-t1x9gknd 1881 1 Group group NN cord-010119-t1x9gknd 1881 2 comparisons comparison NNS cord-010119-t1x9gknd 1881 3 were be VBD cord-010119-t1x9gknd 1881 4 made make VBN cord-010119-t1x9gknd 1881 5 based base VBN cord-010119-t1x9gknd 1881 6 on on IN cord-010119-t1x9gknd 1881 7 hospital hospital NN cord-010119-t1x9gknd 1881 8 location location NN cord-010119-t1x9gknd 1881 9 , , , cord-010119-t1x9gknd 1881 10 level level NN cord-010119-t1x9gknd 1881 11 of of IN cord-010119-t1x9gknd 1881 12 care care NN cord-010119-t1x9gknd 1881 13 and and CC cord-010119-t1x9gknd 1881 14 history history NN cord-010119-t1x9gknd 1881 15 of of IN cord-010119-t1x9gknd 1881 16 TTP TTP NNP cord-010119-t1x9gknd 1881 17 using use VBG cord-010119-t1x9gknd 1881 18 a a DT cord-010119-t1x9gknd 1881 19 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 1881 20 rank rank NN cord-010119-t1x9gknd 1881 21 - - HYPH cord-010119-t1x9gknd 1881 22 sum sum NN cord-010119-t1x9gknd 1881 23 test test NN cord-010119-t1x9gknd 1881 24 . . . cord-010119-t1x9gknd 1882 1 Results result NNS cord-010119-t1x9gknd 1882 2 / / SYM cord-010119-t1x9gknd 1882 3 Finding finding NN cord-010119-t1x9gknd 1882 4 : : : cord-010119-t1x9gknd 1883 1 Of of IN cord-010119-t1x9gknd 1883 2 the the DT cord-010119-t1x9gknd 1883 3 96 96 CD cord-010119-t1x9gknd 1883 4 TTP TTP NNP cord-010119-t1x9gknd 1883 5 patients patient NNS cord-010119-t1x9gknd 1883 6 identified identify VBN cord-010119-t1x9gknd 1883 7 , , , cord-010119-t1x9gknd 1883 8 22 22 CD cord-010119-t1x9gknd 1883 9 were be VBD cord-010119-t1x9gknd 1883 10 excluded exclude VBN cord-010119-t1x9gknd 1883 11 due due IN cord-010119-t1x9gknd 1883 12 to to IN cord-010119-t1x9gknd 1883 13 missing miss VBG cord-010119-t1x9gknd 1883 14 temporal temporal JJ cord-010119-t1x9gknd 1883 15 data datum NNS cord-010119-t1x9gknd 1883 16 for for IN cord-010119-t1x9gknd 1883 17 important important JJ cord-010119-t1x9gknd 1883 18 variables variable NNS cord-010119-t1x9gknd 1883 19 . . . cord-010119-t1x9gknd 1884 1 The the DT cord-010119-t1x9gknd 1884 2 majority majority NN cord-010119-t1x9gknd 1884 3 ( ( -LRB- cord-010119-t1x9gknd 1884 4 85 85 CD cord-010119-t1x9gknd 1884 5 % % NN cord-010119-t1x9gknd 1884 6 ) ) -RRB- cord-010119-t1x9gknd 1884 7 of of IN cord-010119-t1x9gknd 1884 8 patients patient NNS cord-010119-t1x9gknd 1884 9 were be VBD cord-010119-t1x9gknd 1884 10 treated treat VBN cord-010119-t1x9gknd 1884 11 at at IN cord-010119-t1x9gknd 1884 12 central central JJ cord-010119-t1x9gknd 1884 13 academic academic JJ cord-010119-t1x9gknd 1884 14 centers center NNS cord-010119-t1x9gknd 1884 15 , , , cord-010119-t1x9gknd 1884 16 with with IN cord-010119-t1x9gknd 1884 17 the the DT cord-010119-t1x9gknd 1884 18 remainder remainder NN cord-010119-t1x9gknd 1884 19 being be VBG cord-010119-t1x9gknd 1884 20 treated treat VBN cord-010119-t1x9gknd 1884 21 at at IN cord-010119-t1x9gknd 1884 22 peripheral peripheral JJ cord-010119-t1x9gknd 1884 23 sites site NNS cord-010119-t1x9gknd 1884 24 . . . cord-010119-t1x9gknd 1885 1 Fifteen fifteen CD cord-010119-t1x9gknd 1885 2 patients patient NNS cord-010119-t1x9gknd 1885 3 ( ( -LRB- cord-010119-t1x9gknd 1885 4 20 20 CD cord-010119-t1x9gknd 1885 5 % % NN cord-010119-t1x9gknd 1885 6 ) ) -RRB- cord-010119-t1x9gknd 1885 7 had have VBD cord-010119-t1x9gknd 1885 8 a a DT cord-010119-t1x9gknd 1885 9 prior prior JJ cord-010119-t1x9gknd 1885 10 history history NN cord-010119-t1x9gknd 1885 11 of of IN cord-010119-t1x9gknd 1885 12 TTP TTP NNP cord-010119-t1x9gknd 1885 13 and and CC cord-010119-t1x9gknd 1885 14 26 26 CD cord-010119-t1x9gknd 1885 15 % % NN cord-010119-t1x9gknd 1885 16 had have VBD cord-010119-t1x9gknd 1885 17 severe severe JJ cord-010119-t1x9gknd 1885 18 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 1885 19 deficiency deficiency NN cord-010119-t1x9gknd 1885 20 on on IN cord-010119-t1x9gknd 1885 21 admission admission NN cord-010119-t1x9gknd 1885 22 . . . cord-010119-t1x9gknd 1886 1 The the DT cord-010119-t1x9gknd 1886 2 median median JJ cord-010119-t1x9gknd 1886 3 time time NN cord-010119-t1x9gknd 1886 4 from from IN cord-010119-t1x9gknd 1886 5 TPE TPE NNP cord-010119-t1x9gknd 1886 6 request request NN cord-010119-t1x9gknd 1886 7 to to IN cord-010119-t1x9gknd 1886 8 initiation initiation NN cord-010119-t1x9gknd 1886 9 was be VBD cord-010119-t1x9gknd 1886 10 5.6 5.6 CD cord-010119-t1x9gknd 1886 11 hours hour NNS cord-010119-t1x9gknd 1886 12 ( ( -LRB- cord-010119-t1x9gknd 1886 13 interquartile interquartile JJ cord-010119-t1x9gknd 1886 14 range range NN cord-010119-t1x9gknd 1886 15 : : : cord-010119-t1x9gknd 1886 16 4.7 4.7 CD cord-010119-t1x9gknd 1886 17 - - HYPH cord-010119-t1x9gknd 1886 18 7.2 7.2 CD cord-010119-t1x9gknd 1886 19 hours hour NNS cord-010119-t1x9gknd 1886 20 ) ) -RRB- cord-010119-t1x9gknd 1886 21 . . . cord-010119-t1x9gknd 1887 1 There there EX cord-010119-t1x9gknd 1887 2 were be VBD cord-010119-t1x9gknd 1887 3 non non JJ cord-010119-t1x9gknd 1887 4 - - JJ cord-010119-t1x9gknd 1887 5 significant significant JJ cord-010119-t1x9gknd 1887 6 trends trend NNS cord-010119-t1x9gknd 1887 7 to to IN cord-010119-t1x9gknd 1887 8 shorter short JJR cord-010119-t1x9gknd 1887 9 time time NN cord-010119-t1x9gknd 1887 10 intervals interval NNS cord-010119-t1x9gknd 1887 11 from from IN cord-010119-t1x9gknd 1887 12 request request NN cord-010119-t1x9gknd 1887 13 to to IN cord-010119-t1x9gknd 1887 14 CV CV NNP cord-010119-t1x9gknd 1887 15 access access NN cord-010119-t1x9gknd 1887 16 and and CC cord-010119-t1x9gknd 1887 17 request request NN cord-010119-t1x9gknd 1887 18 to to IN cord-010119-t1x9gknd 1887 19 TPE TPE NNP cord-010119-t1x9gknd 1887 20 initiation initiation NN cord-010119-t1x9gknd 1887 21 in in IN cord-010119-t1x9gknd 1887 22 patients patient NNS cord-010119-t1x9gknd 1887 23 admitted admit VBN cord-010119-t1x9gknd 1887 24 to to IN cord-010119-t1x9gknd 1887 25 the the DT cord-010119-t1x9gknd 1887 26 intensive intensive JJ cord-010119-t1x9gknd 1887 27 care care NN cord-010119-t1x9gknd 1887 28 unit unit NN cord-010119-t1x9gknd 1887 29 ( ( -LRB- cord-010119-t1x9gknd 1887 30 ICU ICU NNP cord-010119-t1x9gknd 1887 31 ) ) -RRB- cord-010119-t1x9gknd 1887 32 versus versus IN cord-010119-t1x9gknd 1887 33 non non JJ cord-010119-t1x9gknd 1887 34 - - JJ cord-010119-t1x9gknd 1887 35 ICU icu JJ cord-010119-t1x9gknd 1887 36 patients patient NNS cord-010119-t1x9gknd 1887 37 ( ( -LRB- cord-010119-t1x9gknd 1887 38 table table NN cord-010119-t1x9gknd 1887 39 1 1 CD cord-010119-t1x9gknd 1887 40 ) ) -RRB- cord-010119-t1x9gknd 1887 41 . . . cord-010119-t1x9gknd 1888 1 Treatment treatment NN cord-010119-t1x9gknd 1888 2 was be VBD cord-010119-t1x9gknd 1888 3 not not RB cord-010119-t1x9gknd 1888 4 started start VBN cord-010119-t1x9gknd 1888 5 within within IN cord-010119-t1x9gknd 1888 6 an an DT cord-010119-t1x9gknd 1888 7 8-hour 8-hour CD cord-010119-t1x9gknd 1888 8 window window NN cord-010119-t1x9gknd 1888 9 in in IN cord-010119-t1x9gknd 1888 10 13 13 CD cord-010119-t1x9gknd 1888 11 patients patient NNS cord-010119-t1x9gknd 1888 12 ; ; : cord-010119-t1x9gknd 1888 13 the the DT cord-010119-t1x9gknd 1888 14 median median JJ cord-010119-t1x9gknd 1888 15 time time NN cord-010119-t1x9gknd 1888 16 to to IN cord-010119-t1x9gknd 1888 17 CV CV NNP cord-010119-t1x9gknd 1888 18 access access NN cord-010119-t1x9gknd 1888 19 was be VBD cord-010119-t1x9gknd 1888 20 significantly significantly RB cord-010119-t1x9gknd 1888 21 longer long JJR cord-010119-t1x9gknd 1888 22 in in IN cord-010119-t1x9gknd 1888 23 these these DT cord-010119-t1x9gknd 1888 24 patients patient NNS cord-010119-t1x9gknd 1888 25 ( ( -LRB- cord-010119-t1x9gknd 1888 26 5.8 5.8 CD cord-010119-t1x9gknd 1888 27 vs vs IN cord-010119-t1x9gknd 1888 28 2.47 2.47 CD cord-010119-t1x9gknd 1888 29 hours hour NNS cord-010119-t1x9gknd 1888 30 , , , cord-010119-t1x9gknd 1888 31 p<0.001 p<0.001 CD cord-010119-t1x9gknd 1888 32 ) ) -RRB- cord-010119-t1x9gknd 1888 33 . . . cord-010119-t1x9gknd 1889 1 Two two CD cord-010119-t1x9gknd 1889 2 of of IN cord-010119-t1x9gknd 1889 3 these these DT cord-010119-t1x9gknd 1889 4 patients patient NNS cord-010119-t1x9gknd 1889 5 had have VBD cord-010119-t1x9gknd 1889 6 a a DT cord-010119-t1x9gknd 1889 7 prior prior JJ cord-010119-t1x9gknd 1889 8 history history NN cord-010119-t1x9gknd 1889 9 of of IN cord-010119-t1x9gknd 1889 10 TTP TTP NNP cord-010119-t1x9gknd 1889 11 and and CC cord-010119-t1x9gknd 1889 12 only only RB cord-010119-t1x9gknd 1889 13 four four CD cord-010119-t1x9gknd 1889 14 patients patient NNS cord-010119-t1x9gknd 1889 15 had have VBD cord-010119-t1x9gknd 1889 16 severe severe JJ cord-010119-t1x9gknd 1889 17 ADAMTS-13 adamts-13 ADD cord-010119-t1x9gknd 1889 18 deficiency deficiency NN cord-010119-t1x9gknd 1889 19 . . . cord-010119-t1x9gknd 1890 1 The the DT cord-010119-t1x9gknd 1890 2 majority majority NN cord-010119-t1x9gknd 1890 3 ( ( -LRB- cord-010119-t1x9gknd 1890 4 more more JJR cord-010119-t1x9gknd 1890 5 than than IN cord-010119-t1x9gknd 1890 6 70 70 CD cord-010119-t1x9gknd 1890 7 % % NN cord-010119-t1x9gknd 1890 8 ) ) -RRB- cord-010119-t1x9gknd 1890 9 of of IN cord-010119-t1x9gknd 1890 10 the the DT cord-010119-t1x9gknd 1890 11 time time NN cord-010119-t1x9gknd 1890 12 interval interval NN cord-010119-t1x9gknd 1890 13 between between IN cord-010119-t1x9gknd 1890 14 TPE TPE NNP cord-010119-t1x9gknd 1890 15 request request NN cord-010119-t1x9gknd 1890 16 and and CC cord-010119-t1x9gknd 1890 17 TPE TPE NNP cord-010119-t1x9gknd 1890 18 initiation initiation NN cord-010119-t1x9gknd 1890 19 was be VBD cord-010119-t1x9gknd 1890 20 spent spend VBN cord-010119-t1x9gknd 1890 21 obtaining obtain VBG cord-010119-t1x9gknd 1890 22 CV cv NN cord-010119-t1x9gknd 1890 23 access access NN cord-010119-t1x9gknd 1890 24 and and CC cord-010119-t1x9gknd 1890 25 plasma plasma NN cord-010119-t1x9gknd 1890 26 products product NNS cord-010119-t1x9gknd 1890 27 . . . cord-010119-t1x9gknd 1891 1 There there EX cord-010119-t1x9gknd 1891 2 were be VBD cord-010119-t1x9gknd 1891 3 no no DT cord-010119-t1x9gknd 1891 4 significant significant JJ cord-010119-t1x9gknd 1891 5 differences difference NNS cord-010119-t1x9gknd 1891 6 in in IN cord-010119-t1x9gknd 1891 7 time time NN cord-010119-t1x9gknd 1891 8 intervals interval NNS cord-010119-t1x9gknd 1891 9 comparing compare VBG cord-010119-t1x9gknd 1891 10 patients patient NNS cord-010119-t1x9gknd 1891 11 with with IN cord-010119-t1x9gknd 1891 12 a a DT cord-010119-t1x9gknd 1891 13 new new JJ cord-010119-t1x9gknd 1891 14 diagnosis diagnosis NN cord-010119-t1x9gknd 1891 15 of of IN cord-010119-t1x9gknd 1891 16 TTP TTP NNP cord-010119-t1x9gknd 1891 17 versus versus IN cord-010119-t1x9gknd 1891 18 patients patient NNS cord-010119-t1x9gknd 1891 19 with with IN cord-010119-t1x9gknd 1891 20 recurrent/ recurrent/ CD cord-010119-t1x9gknd 1891 21 relapsed relapsed JJ cord-010119-t1x9gknd 1891 22 disease disease NN cord-010119-t1x9gknd 1891 23 ( ( -LRB- cord-010119-t1x9gknd 1891 24 table table NN cord-010119-t1x9gknd 1891 25 1 1 CD cord-010119-t1x9gknd 1891 26 ) ) -RRB- cord-010119-t1x9gknd 1891 27 or or CC cord-010119-t1x9gknd 1891 28 between between IN cord-010119-t1x9gknd 1891 29 patients patient NNS cord-010119-t1x9gknd 1891 30 treated treat VBN cord-010119-t1x9gknd 1891 31 at at IN cord-010119-t1x9gknd 1891 32 a a DT cord-010119-t1x9gknd 1891 33 central central JJ cord-010119-t1x9gknd 1891 34 academic academic JJ cord-010119-t1x9gknd 1891 35 center center NN cord-010119-t1x9gknd 1891 36 versus versus IN cord-010119-t1x9gknd 1891 37 a a DT cord-010119-t1x9gknd 1891 38 peripheral peripheral JJ cord-010119-t1x9gknd 1891 39 hospital hospital NN cord-010119-t1x9gknd 1891 40 . . . cord-010119-t1x9gknd 1892 1 Conclusion conclusion NN cord-010119-t1x9gknd 1892 2 : : : cord-010119-t1x9gknd 1893 1 The the DT cord-010119-t1x9gknd 1893 2 consensus consensus NN cord-010119-t1x9gknd 1893 3 4 4 CD cord-010119-t1x9gknd 1893 4 - - SYM cord-010119-t1x9gknd 1893 5 8 8 CD cord-010119-t1x9gknd 1893 6 hour hour NN cord-010119-t1x9gknd 1893 7 target target NN cord-010119-t1x9gknd 1893 8 window window NN cord-010119-t1x9gknd 1893 9 from from IN cord-010119-t1x9gknd 1893 10 TPE TPE NNP cord-010119-t1x9gknd 1893 11 request request NN cord-010119-t1x9gknd 1893 12 to to IN cord-010119-t1x9gknd 1893 13 initiation initiation NN cord-010119-t1x9gknd 1893 14 appears appear VBZ cord-010119-t1x9gknd 1893 15 feasible feasible JJ cord-010119-t1x9gknd 1893 16 for for IN cord-010119-t1x9gknd 1893 17 a a DT cord-010119-t1x9gknd 1893 18 centralized centralized JJ cord-010119-t1x9gknd 1893 19 TPE TPE NNP cord-010119-t1x9gknd 1893 20 program program NN cord-010119-t1x9gknd 1893 21 servicing service VBG cord-010119-t1x9gknd 1893 22 a a DT cord-010119-t1x9gknd 1893 23 multi-48A multi-48A NNP cord-010119-t1x9gknd 1893 24 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 1893 25 2017 2017 CD cord-010119-t1x9gknd 1893 26 Vol Vol NNP cord-010119-t1x9gknd 1893 27 . . . cord-010119-t1x9gknd 1894 1 57 57 CD cord-010119-t1x9gknd 1894 2 Supplement Supplement NNP cord-010119-t1x9gknd 1894 3 S3 S3 NNP cord-010119-t1x9gknd 1894 4 hospital hospital NN cord-010119-t1x9gknd 1894 5 healthcare healthcare NN cord-010119-t1x9gknd 1894 6 system system NN cord-010119-t1x9gknd 1894 7 . . . cord-010119-t1x9gknd 1895 1 Addressing address VBG cord-010119-t1x9gknd 1895 2 limitations limitation NNS cord-010119-t1x9gknd 1895 3 in in IN cord-010119-t1x9gknd 1895 4 availability availability NN cord-010119-t1x9gknd 1895 5 of of IN cord-010119-t1x9gknd 1895 6 CV CV NNP cord-010119-t1x9gknd 1895 7 access access NN cord-010119-t1x9gknd 1895 8 would would MD cord-010119-t1x9gknd 1895 9 likely likely RB cord-010119-t1x9gknd 1895 10 yield yield VB cord-010119-t1x9gknd 1895 11 the the DT cord-010119-t1x9gknd 1895 12 greatest great JJS cord-010119-t1x9gknd 1895 13 improvement improvement NN cord-010119-t1x9gknd 1895 14 in in IN cord-010119-t1x9gknd 1895 15 timeliness timeliness NN cord-010119-t1x9gknd 1895 16 of of IN cord-010119-t1x9gknd 1895 17 urgent urgent JJ cord-010119-t1x9gknd 1895 18 TPE tpe NN cord-010119-t1x9gknd 1895 19 . . . cord-010119-t1x9gknd 1896 1 Cytoreductive Cytoreductive NNP cord-010119-t1x9gknd 1896 2 Therapy Therapy NNP cord-010119-t1x9gknd 1896 3 for for IN cord-010119-t1x9gknd 1896 4 Cellular Cellular NNP cord-010119-t1x9gknd 1896 5 Hyperviscosity Hyperviscosity NNP cord-010119-t1x9gknd 1896 6 : : : cord-010119-t1x9gknd 1896 7 Utility utility NN cord-010119-t1x9gknd 1896 8 of of IN cord-010119-t1x9gknd 1896 9 Cytapheresis Cytapheresis NNP cord-010119-t1x9gknd 1896 10 Treatment Treatment NNP cord-010119-t1x9gknd 1896 11 for for IN cord-010119-t1x9gknd 1896 12 Chronic Chronic NNP cord-010119-t1x9gknd 1896 13 Myelogenous Myelogenous NNP cord-010119-t1x9gknd 1896 14 Leukemia Leukemia NNP cord-010119-t1x9gknd 1896 15 and and CC cord-010119-t1x9gknd 1896 16 Essential Essential NNP cord-010119-t1x9gknd 1896 17 Thrombocythemia Thrombocythemia NNP cord-010119-t1x9gknd 1896 18 . . . cord-010119-t1x9gknd 1897 1 Jan Jan NNP cord-010119-t1x9gknd 1897 2 C C NNP cord-010119-t1x9gknd 1897 3 Hofmann Hofmann NNP cord-010119-t1x9gknd 1897 4 * * NFP cord-010119-t1x9gknd 1897 5 and and CC cord-010119-t1x9gknd 1897 6 Dobri Dobri NNP cord-010119-t1x9gknd 1897 7 D D NNP cord-010119-t1x9gknd 1897 8 Kiprov Kiprov NNP cord-010119-t1x9gknd 1897 9 . . . cord-010119-t1x9gknd 1898 1 California California NNP cord-010119-t1x9gknd 1898 2 Pacific Pacific NNP cord-010119-t1x9gknd 1898 3 Medical Medical NNP cord-010119-t1x9gknd 1898 4 Center Center NNP cord-010119-t1x9gknd 1898 5 Background Background NNP cord-010119-t1x9gknd 1898 6 / / SYM cord-010119-t1x9gknd 1898 7 Case Case NNP cord-010119-t1x9gknd 1898 8 Studies Studies NNPS cord-010119-t1x9gknd 1898 9 : : : cord-010119-t1x9gknd 1898 10 Several several JJ cord-010119-t1x9gknd 1898 11 retrospective retrospective NN cord-010119-t1x9gknd 1898 12 , , , cord-010119-t1x9gknd 1898 13 case case NN cord-010119-t1x9gknd 1898 14 series series NNP cord-010119-t1x9gknd 1898 15 have have VBP cord-010119-t1x9gknd 1898 16 suggested suggest VBN cord-010119-t1x9gknd 1898 17 that that IN cord-010119-t1x9gknd 1898 18 cytoreductive cytoreductive JJ cord-010119-t1x9gknd 1898 19 therapy therapy NN cord-010119-t1x9gknd 1898 20 to to TO cord-010119-t1x9gknd 1898 21 treat treat VB cord-010119-t1x9gknd 1898 22 cellular cellular JJ cord-010119-t1x9gknd 1898 23 hyperviscosity hyperviscosity NN cord-010119-t1x9gknd 1898 24 and and CC cord-010119-t1x9gknd 1898 25 prevent prevent VB cord-010119-t1x9gknd 1898 26 thrombotic thrombotic JJ cord-010119-t1x9gknd 1898 27 events event NNS cord-010119-t1x9gknd 1898 28 in in IN cord-010119-t1x9gknd 1898 29 patients patient NNS cord-010119-t1x9gknd 1898 30 ( ( -LRB- cord-010119-t1x9gknd 1898 31 pts pt NNS cord-010119-t1x9gknd 1898 32 ) ) -RRB- cord-010119-t1x9gknd 1898 33 with with IN cord-010119-t1x9gknd 1898 34 chronic chronic JJ cord-010119-t1x9gknd 1898 35 myelogenous myelogenous NN cord-010119-t1x9gknd 1898 36 leukemia leukemia NN cord-010119-t1x9gknd 1898 37 with with IN cord-010119-t1x9gknd 1898 38 accelerated accelerated JJ cord-010119-t1x9gknd 1898 39 transformation transformation NN cord-010119-t1x9gknd 1898 40 ( ( -LRB- cord-010119-t1x9gknd 1898 41 CML CML NNP cord-010119-t1x9gknd 1898 42 - - HYPH cord-010119-t1x9gknd 1898 43 AT at NN cord-010119-t1x9gknd 1898 44 ) ) -RRB- cord-010119-t1x9gknd 1898 45 or or CC cord-010119-t1x9gknd 1898 46 essential essential JJ cord-010119-t1x9gknd 1898 47 thrombocythemia thrombocythemia NN cord-010119-t1x9gknd 1898 48 ( ( -LRB- cord-010119-t1x9gknd 1898 49 ET ET NNP cord-010119-t1x9gknd 1898 50 ) ) -RRB- cord-010119-t1x9gknd 1898 51 may may MD cord-010119-t1x9gknd 1898 52 improve improve VB cord-010119-t1x9gknd 1898 53 short short JJ cord-010119-t1x9gknd 1898 54 - - HYPH cord-010119-t1x9gknd 1898 55 term term NN cord-010119-t1x9gknd 1898 56 outcomes outcome NNS cord-010119-t1x9gknd 1898 57 . . . cord-010119-t1x9gknd 1899 1 However however RB cord-010119-t1x9gknd 1899 2 , , , cord-010119-t1x9gknd 1899 3 no no DT cord-010119-t1x9gknd 1899 4 randomized randomized JJ cord-010119-t1x9gknd 1899 5 controlled control VBN cord-010119-t1x9gknd 1899 6 trial trial NN cord-010119-t1x9gknd 1899 7 ( ( -LRB- cord-010119-t1x9gknd 1899 8 RCT RCT NNP cord-010119-t1x9gknd 1899 9 ) ) -RRB- cord-010119-t1x9gknd 1899 10 assessing assess VBG cord-010119-t1x9gknd 1899 11 the the DT cord-010119-t1x9gknd 1899 12 efficacy efficacy NN cord-010119-t1x9gknd 1899 13 of of IN cord-010119-t1x9gknd 1899 14 cytapheresis cytapheresis NN cord-010119-t1x9gknd 1899 15 treatment treatment NN cord-010119-t1x9gknd 1899 16 in in IN cord-010119-t1x9gknd 1899 17 this this DT cord-010119-t1x9gknd 1899 18 group group NN cord-010119-t1x9gknd 1899 19 of of IN cord-010119-t1x9gknd 1899 20 pts pts NNP cord-010119-t1x9gknd 1899 21 has have VBZ cord-010119-t1x9gknd 1899 22 been be VBN cord-010119-t1x9gknd 1899 23 performed perform VBN cord-010119-t1x9gknd 1899 24 . . . cord-010119-t1x9gknd 1900 1 Study Study NNP cord-010119-t1x9gknd 1900 2 Design Design NNP cord-010119-t1x9gknd 1900 3 / / SYM cord-010119-t1x9gknd 1900 4 Method method NN cord-010119-t1x9gknd 1900 5 : : : cord-010119-t1x9gknd 1901 1 From from IN cord-010119-t1x9gknd 1901 2 January January NNP cord-010119-t1x9gknd 1901 3 , , , cord-010119-t1x9gknd 1901 4 2006 2006 CD cord-010119-t1x9gknd 1901 5 through through IN cord-010119-t1x9gknd 1901 6 January January NNP cord-010119-t1x9gknd 1901 7 , , , cord-010119-t1x9gknd 1901 8 2017 2017 CD cord-010119-t1x9gknd 1901 9 , , , cord-010119-t1x9gknd 1901 10 we -PRON- PRP cord-010119-t1x9gknd 1901 11 performed perform VBD cord-010119-t1x9gknd 1901 12 cytapheresis cytapheresis NN cord-010119-t1x9gknd 1901 13 ( ( -LRB- cord-010119-t1x9gknd 1901 14 Cy Cy NNP cord-010119-t1x9gknd 1901 15 ) ) -RRB- cord-010119-t1x9gknd 1901 16 treatments treatment NNS cord-010119-t1x9gknd 1901 17 ( ( -LRB- cord-010119-t1x9gknd 1901 18 txs txs NNP cord-010119-t1x9gknd 1901 19 ) ) -RRB- cord-010119-t1x9gknd 1901 20 for for IN cord-010119-t1x9gknd 1901 21 123 123 CD cord-010119-t1x9gknd 1901 22 pts pt NNS cord-010119-t1x9gknd 1901 23 with with IN cord-010119-t1x9gknd 1901 24 either either CC cord-010119-t1x9gknd 1901 25 CML CML NNP cord-010119-t1x9gknd 1901 26 - - HYPH cord-010119-t1x9gknd 1901 27 AT AT NNP cord-010119-t1x9gknd 1901 28 or or CC cord-010119-t1x9gknd 1901 29 ET ET NNP cord-010119-t1x9gknd 1901 30 , , , cord-010119-t1x9gknd 1901 31 and and CC cord-010119-t1x9gknd 1901 32 clinical clinical JJ cord-010119-t1x9gknd 1901 33 and/or and/or CC cord-010119-t1x9gknd 1901 34 laboratory laboratory NN cord-010119-t1x9gknd 1901 35 evidence evidence NN cord-010119-t1x9gknd 1901 36 of of IN cord-010119-t1x9gknd 1901 37 cellular cellular JJ cord-010119-t1x9gknd 1901 38 hyperviscosity hyperviscosity NN cord-010119-t1x9gknd 1901 39 . . . cord-010119-t1x9gknd 1902 1 84 84 CD cord-010119-t1x9gknd 1902 2 pts pt NNS cord-010119-t1x9gknd 1902 3 ( ( -LRB- cord-010119-t1x9gknd 1902 4 68 68 CD cord-010119-t1x9gknd 1902 5 % % NN cord-010119-t1x9gknd 1902 6 ) ) -RRB- cord-010119-t1x9gknd 1902 7 had have VBD cord-010119-t1x9gknd 1902 8 CML CML NNP cord-010119-t1x9gknd 1902 9 - - HYPH cord-010119-t1x9gknd 1902 10 AT AT NNP cord-010119-t1x9gknd 1902 11 and and CC cord-010119-t1x9gknd 1902 12 received receive VBD cord-010119-t1x9gknd 1902 13 319 319 CD cord-010119-t1x9gknd 1902 14 leukapheresis leukapheresis NN cord-010119-t1x9gknd 1902 15 ( ( -LRB- cord-010119-t1x9gknd 1902 16 Lp Lp NNP cord-010119-t1x9gknd 1902 17 ) ) -RRB- cord-010119-t1x9gknd 1902 18 txs txs NNP cord-010119-t1x9gknd 1902 19 ; ; : cord-010119-t1x9gknd 1902 20 39 39 CD cord-010119-t1x9gknd 1902 21 pts pt NNS cord-010119-t1x9gknd 1902 22 ( ( -LRB- cord-010119-t1x9gknd 1902 23 32 32 CD cord-010119-t1x9gknd 1902 24 % % NN cord-010119-t1x9gknd 1902 25 ) ) -RRB- cord-010119-t1x9gknd 1902 26 had have VBD cord-010119-t1x9gknd 1902 27 ET ET NNP cord-010119-t1x9gknd 1902 28 and and CC cord-010119-t1x9gknd 1902 29 received receive VBD cord-010119-t1x9gknd 1902 30 124 124 CD cord-010119-t1x9gknd 1902 31 thrombocytapheresis thrombocytapheresis NN cord-010119-t1x9gknd 1902 32 ( ( -LRB- cord-010119-t1x9gknd 1902 33 Tc Tc NNP cord-010119-t1x9gknd 1902 34 ) ) -RRB- cord-010119-t1x9gknd 1902 35 txs txs FW cord-010119-t1x9gknd 1902 36 . . . cord-010119-t1x9gknd 1903 1 CML CML NNP cord-010119-t1x9gknd 1903 2 - - HYPH cord-010119-t1x9gknd 1903 3 AT AT NNP cord-010119-t1x9gknd 1903 4 pts pt NNS cord-010119-t1x9gknd 1903 5 presented present VBN cord-010119-t1x9gknd 1903 6 with with IN cord-010119-t1x9gknd 1903 7 median median JJ cord-010119-t1x9gknd 1903 8 WBC WBC NNP cord-010119-t1x9gknd 1904 1 398 398 CD cord-010119-t1x9gknd 1904 2 x x SYM cord-010119-t1x9gknd 1904 3 10 10 CD cord-010119-t1x9gknd 1904 4 9 9 CD cord-010119-t1x9gknd 1904 5 /L /L . cord-010119-t1x9gknd 1904 6 ( ( -LRB- cord-010119-t1x9gknd 1904 7 range range NNP cord-010119-t1x9gknd 1904 8 193 193 CD cord-010119-t1x9gknd 1904 9 - - SYM cord-010119-t1x9gknd 1904 10 689 689 CD cord-010119-t1x9gknd 1904 11 x x SYM cord-010119-t1x9gknd 1904 12 10 10 CD cord-010119-t1x9gknd 1904 13 9 9 CD cord-010119-t1x9gknd 1904 14 /L /l CD cord-010119-t1x9gknd 1904 15 ) ) -RRB- cord-010119-t1x9gknd 1904 16 , , , cord-010119-t1x9gknd 1904 17 of of IN cord-010119-t1x9gknd 1904 18 which which WDT cord-010119-t1x9gknd 1904 19 63 63 CD cord-010119-t1x9gknd 1904 20 % % NN cord-010119-t1x9gknd 1904 21 had have VBD cord-010119-t1x9gknd 1904 22 blast blast NN cord-010119-t1x9gknd 1904 23 percent percent NN cord-010119-t1x9gknd 1904 24 > > XX cord-010119-t1x9gknd 1904 25 75 75 CD cord-010119-t1x9gknd 1904 26 % % NN cord-010119-t1x9gknd 1904 27 or or CC cord-010119-t1x9gknd 1904 28 blast blast NN cord-010119-t1x9gknd 1904 29 count count NN cord-010119-t1x9gknd 1905 1 > > XX cord-010119-t1x9gknd 1906 1 100 100 CD cord-010119-t1x9gknd 1906 2 x x SYM cord-010119-t1x9gknd 1906 3 10 10 CD cord-010119-t1x9gknd 1906 4 9 9 CD cord-010119-t1x9gknd 1907 1 /L. /L. . cord-010119-t1x9gknd 1908 1 Median median JJ cord-010119-t1x9gknd 1908 2 age age NN cord-010119-t1x9gknd 1908 3 was be VBD cord-010119-t1x9gknd 1908 4 42 42 CD cord-010119-t1x9gknd 1908 5 years year NNS cord-010119-t1x9gknd 1908 6 ( ( -LRB- cord-010119-t1x9gknd 1908 7 8 8 CD cord-010119-t1x9gknd 1908 8 - - SYM cord-010119-t1x9gknd 1908 9 79 79 CD cord-010119-t1x9gknd 1908 10 years year NNS cord-010119-t1x9gknd 1908 11 ) ) -RRB- cord-010119-t1x9gknd 1908 12 ; ; : cord-010119-t1x9gknd 1908 13 62 62 CD cord-010119-t1x9gknd 1908 14 % % NN cord-010119-t1x9gknd 1908 15 were be VBD cord-010119-t1x9gknd 1908 16 male male JJ cord-010119-t1x9gknd 1908 17 . . . cord-010119-t1x9gknd 1909 1 CNS CNS NNP cord-010119-t1x9gknd 1909 2 symptoms symptom NNS cord-010119-t1x9gknd 1909 3 ( ( -LRB- cord-010119-t1x9gknd 1909 4 sxs sxs NNP cord-010119-t1x9gknd 1909 5 ) ) -RRB- cord-010119-t1x9gknd 1909 6 of of IN cord-010119-t1x9gknd 1909 7 leukostasis leukostasis NNP cord-010119-t1x9gknd 1909 8 ( ( -LRB- cord-010119-t1x9gknd 1909 9 lks lks NNP cord-010119-t1x9gknd 1909 10 ) ) -RRB- cord-010119-t1x9gknd 1909 11 were be VBD cord-010119-t1x9gknd 1909 12 defined define VBN cord-010119-t1x9gknd 1909 13 as as IN cord-010119-t1x9gknd 1909 14 : : : cord-010119-t1x9gknd 1909 15 headache headache NN cord-010119-t1x9gknd 1909 16 , , , cord-010119-t1x9gknd 1909 17 cognitive cognitive JJ cord-010119-t1x9gknd 1909 18 decline decline NN cord-010119-t1x9gknd 1909 19 , , , cord-010119-t1x9gknd 1909 20 confusion confusion NN cord-010119-t1x9gknd 1909 21 , , , cord-010119-t1x9gknd 1909 22 somnolence somnolence NN cord-010119-t1x9gknd 1909 23 , , , cord-010119-t1x9gknd 1909 24 visual visual JJ cord-010119-t1x9gknd 1909 25 abnormalities abnormality NNS cord-010119-t1x9gknd 1909 26 , , , cord-010119-t1x9gknd 1909 27 or or CC cord-010119-t1x9gknd 1909 28 seizure seizure NN cord-010119-t1x9gknd 1909 29 ; ; : cord-010119-t1x9gknd 1909 30 pulmonary pulmonary JJ cord-010119-t1x9gknd 1909 31 ( ( -LRB- cord-010119-t1x9gknd 1909 32 pulm pulm NNP cord-010119-t1x9gknd 1909 33 ) ) -RRB- cord-010119-t1x9gknd 1909 34 sxs sxs NNP cord-010119-t1x9gknd 1909 35 of of IN cord-010119-t1x9gknd 1909 36 lks lks NNP cord-010119-t1x9gknd 1909 37 were be VBD cord-010119-t1x9gknd 1909 38 defined define VBN cord-010119-t1x9gknd 1909 39 as as IN cord-010119-t1x9gknd 1909 40 : : : cord-010119-t1x9gknd 1909 41 dyspnea dyspnea NN cord-010119-t1x9gknd 1909 42 , , , cord-010119-t1x9gknd 1909 43 hypoxia hypoxia NN cord-010119-t1x9gknd 1909 44 , , , cord-010119-t1x9gknd 1909 45 or or CC cord-010119-t1x9gknd 1909 46 bilateral bilateral JJ cord-010119-t1x9gknd 1909 47 chest chest NN cord-010119-t1x9gknd 1909 48 infiltrates infiltrate VBZ cord-010119-t1x9gknd 1909 49 . . . cord-010119-t1x9gknd 1910 1 22 22 CD cord-010119-t1x9gknd 1910 2 % % NN cord-010119-t1x9gknd 1910 3 of of IN cord-010119-t1x9gknd 1910 4 CML CML NNP cord-010119-t1x9gknd 1910 5 - - HYPH cord-010119-t1x9gknd 1910 6 AT AT NNP cord-010119-t1x9gknd 1910 7 pts pts NNP cord-010119-t1x9gknd 1910 8 had have VBD cord-010119-t1x9gknd 1910 9 no no DT cord-010119-t1x9gknd 1910 10 sxs sxs NN cord-010119-t1x9gknd 1910 11 of of IN cord-010119-t1x9gknd 1910 12 lks lks NNP cord-010119-t1x9gknd 1910 13 ; ; : cord-010119-t1x9gknd 1910 14 40 40 CD cord-010119-t1x9gknd 1910 15 % % NN cord-010119-t1x9gknd 1910 16 pts pt NNS cord-010119-t1x9gknd 1910 17 had have VBD cord-010119-t1x9gknd 1910 18 sxs sxs JJ cord-010119-t1x9gknd 1910 19 of of IN cord-010119-t1x9gknd 1910 20 either either DT cord-010119-t1x9gknd 1910 21 CNS CNS NNP cord-010119-t1x9gknd 1910 22 or or CC cord-010119-t1x9gknd 1910 23 pulm pulm NNP cord-010119-t1x9gknd 1910 24 lks lks NNP cord-010119-t1x9gknd 1910 25 ( ( -LRB- cord-010119-t1x9gknd 1910 26 1 1 CD cord-010119-t1x9gknd 1910 27 sxs sxs NNP cord-010119-t1x9gknd 1910 28 ) ) -RRB- cord-010119-t1x9gknd 1910 29 , , , cord-010119-t1x9gknd 1910 30 and and CC cord-010119-t1x9gknd 1910 31 38 38 CD cord-010119-t1x9gknd 1910 32 % % NN cord-010119-t1x9gknd 1910 33 pts pt NNS cord-010119-t1x9gknd 1910 34 had have VBD cord-010119-t1x9gknd 1910 35 sxs sxs JJ cord-010119-t1x9gknd 1910 36 of of IN cord-010119-t1x9gknd 1910 37 both both DT cord-010119-t1x9gknd 1910 38 CNS CNS NNP cord-010119-t1x9gknd 1910 39 and and CC cord-010119-t1x9gknd 1910 40 pulm pulm NNP cord-010119-t1x9gknd 1910 41 lks lks NNP cord-010119-t1x9gknd 1910 42 ( ( -LRB- cord-010119-t1x9gknd 1910 43 2 2 CD cord-010119-t1x9gknd 1910 44 sxs sxs NNP cord-010119-t1x9gknd 1910 45 ) ) -RRB- cord-010119-t1x9gknd 1910 46 . . . cord-010119-t1x9gknd 1911 1 ET ET NNP cord-010119-t1x9gknd 1911 2 pts pt NNS cord-010119-t1x9gknd 1911 3 presented present VBN cord-010119-t1x9gknd 1911 4 with with IN cord-010119-t1x9gknd 1911 5 median median JJ cord-010119-t1x9gknd 1911 6 platelet platelet NN cord-010119-t1x9gknd 1911 7 ( ( -LRB- cord-010119-t1x9gknd 1911 8 plt plt NNP cord-010119-t1x9gknd 1911 9 ) ) -RRB- cord-010119-t1x9gknd 1911 10 count count NNP cord-010119-t1x9gknd 1911 11 of of IN cord-010119-t1x9gknd 1911 12 : : : cord-010119-t1x9gknd 1912 1 1738 1738 CD cord-010119-t1x9gknd 1912 2 x x SYM cord-010119-t1x9gknd 1912 3 10 10 CD cord-010119-t1x9gknd 1912 4 9 9 CD cord-010119-t1x9gknd 1912 5 /L /L . cord-010119-t1x9gknd 1912 6 ( ( -LRB- cord-010119-t1x9gknd 1912 7 642 642 CD cord-010119-t1x9gknd 1912 8 - - HYPH cord-010119-t1x9gknd 1912 9 3510 3510 CD cord-010119-t1x9gknd 1913 1 x x LS cord-010119-t1x9gknd 1913 2 10 10 CD cord-010119-t1x9gknd 1914 1 9 9 CD cord-010119-t1x9gknd 1914 2 /L)and /l)and CD cord-010119-t1x9gknd 1914 3 71 71 CD cord-010119-t1x9gknd 1914 4 % % NN cord-010119-t1x9gknd 1914 5 pts pt NNS cord-010119-t1x9gknd 1914 6 had have VBD cord-010119-t1x9gknd 1914 7 sxs sxs NNP cord-010119-t1x9gknd 1914 8 of of IN cord-010119-t1x9gknd 1914 9 thrombosis thrombosis NNP cord-010119-t1x9gknd 1914 10 ( ( -LRB- cord-010119-t1x9gknd 1914 11 evidence evidence NN cord-010119-t1x9gknd 1914 12 of of IN cord-010119-t1x9gknd 1914 13 CVA CVA NNP cord-010119-t1x9gknd 1914 14 or or CC cord-010119-t1x9gknd 1914 15 TIA TIA NNP cord-010119-t1x9gknd 1914 16 , , , cord-010119-t1x9gknd 1914 17 MI MI NNP cord-010119-t1x9gknd 1914 18 , , , cord-010119-t1x9gknd 1914 19 or or CC cord-010119-t1x9gknd 1914 20 DVT DVT NNP cord-010119-t1x9gknd 1914 21 ) ) -RRB- cord-010119-t1x9gknd 1914 22 . . . cord-010119-t1x9gknd 1915 1 Median median JJ cord-010119-t1x9gknd 1915 2 age age NN cord-010119-t1x9gknd 1915 3 was be VBD cord-010119-t1x9gknd 1915 4 66 66 CD cord-010119-t1x9gknd 1915 5 years year NNS cord-010119-t1x9gknd 1915 6 ( ( -LRB- cord-010119-t1x9gknd 1915 7 31 31 CD cord-010119-t1x9gknd 1915 8 - - SYM cord-010119-t1x9gknd 1915 9 89 89 CD cord-010119-t1x9gknd 1915 10 years year NNS cord-010119-t1x9gknd 1915 11 ) ) -RRB- cord-010119-t1x9gknd 1915 12 ; ; : cord-010119-t1x9gknd 1915 13 58 58 CD cord-010119-t1x9gknd 1915 14 % % NN cord-010119-t1x9gknd 1915 15 pts pt NNS cord-010119-t1x9gknd 1915 16 were be VBD cord-010119-t1x9gknd 1915 17 male male JJ cord-010119-t1x9gknd 1915 18 . . . cord-010119-t1x9gknd 1916 1 Results/ Results/ . cord-010119-t1x9gknd 1917 1 Finding finding NN cord-010119-t1x9gknd 1917 2 : : : cord-010119-t1x9gknd 1918 1 All all DT cord-010119-t1x9gknd 1918 2 pts pt NNS cord-010119-t1x9gknd 1918 3 received receive VBD cord-010119-t1x9gknd 1918 4 a a DT cord-010119-t1x9gknd 1918 5 course course NN cord-010119-t1x9gknd 1918 6 of of IN cord-010119-t1x9gknd 1918 7 Cy Cy NNP cord-010119-t1x9gknd 1918 8 tx tx NNP cord-010119-t1x9gknd 1918 9 with with IN cord-010119-t1x9gknd 1918 10 following follow VBG cord-010119-t1x9gknd 1918 11 objectives objective NNS cord-010119-t1x9gknd 1918 12 : : : cord-010119-t1x9gknd 1918 13 1 1 LS cord-010119-t1x9gknd 1918 14 ) ) -RRB- cord-010119-t1x9gknd 1918 15 decreasing decrease VBG cord-010119-t1x9gknd 1918 16 the the DT cord-010119-t1x9gknd 1918 17 risk risk NN cord-010119-t1x9gknd 1918 18 of of IN cord-010119-t1x9gknd 1918 19 thrombotic/ thrombotic/ CD cord-010119-t1x9gknd 1918 20 hemorrhagic hemorrhagic JJ cord-010119-t1x9gknd 1918 21 complications complication NNS cord-010119-t1x9gknd 1918 22 related relate VBN cord-010119-t1x9gknd 1918 23 to to IN cord-010119-t1x9gknd 1918 24 hyperviscosity hyperviscosity NN cord-010119-t1x9gknd 1918 25 , , , cord-010119-t1x9gknd 1918 26 and and CC cord-010119-t1x9gknd 1918 27 2 2 LS cord-010119-t1x9gknd 1918 28 ) ) -RRB- cord-010119-t1x9gknd 1918 29 stabilizing stabilize VBG cord-010119-t1x9gknd 1918 30 CML CML NNP cord-010119-t1x9gknd 1918 31 - - HYPH cord-010119-t1x9gknd 1918 32 AT AT NNP cord-010119-t1x9gknd 1918 33 pts pts NN cord-010119-t1x9gknd 1918 34 for for IN cord-010119-t1x9gknd 1918 35 induction induction NN cord-010119-t1x9gknd 1919 1 chemotherapy chemotherapy NN cord-010119-t1x9gknd 1919 2 ( ( -LRB- cord-010119-t1x9gknd 1919 3 ind ind NNP cord-010119-t1x9gknd 1919 4 chemo chemo NNP cord-010119-t1x9gknd 1919 5 ) ) -RRB- cord-010119-t1x9gknd 1919 6 . . . cord-010119-t1x9gknd 1920 1 WBC WBC NNP cord-010119-t1x9gknd 1920 2 ( ( -LRB- cord-010119-t1x9gknd 1920 3 or or CC cord-010119-t1x9gknd 1920 4 plt plt NNP cord-010119-t1x9gknd 1920 5 ct ct NNP cord-010119-t1x9gknd 1920 6 ) ) -RRB- cord-010119-t1x9gknd 1921 1 tx tx NNP cord-010119-t1x9gknd 1921 2 goals goal NNS cord-010119-t1x9gknd 1921 3 were be VBD cord-010119-t1x9gknd 1921 4 : : : cord-010119-t1x9gknd 1921 5 WBC WBC NNP cord-010119-t1x9gknd 1921 6 count count NNP cord-010119-t1x9gknd 1921 7 ( ( -LRB- cord-010119-t1x9gknd 1921 8 ct ct NN cord-010119-t1x9gknd 1921 9 ) ) -RRB- cord-010119-t1x9gknd 1922 1 < < XX cord-010119-t1x9gknd 1922 2 100 100 CD cord-010119-t1x9gknd 1923 1 x x SYM cord-010119-t1x9gknd 1923 2 10 10 CD cord-010119-t1x9gknd 1923 3 9 9 CD cord-010119-t1x9gknd 1923 4 /L /L . cord-010119-t1x9gknd 1923 5 for for IN cord-010119-t1x9gknd 1923 6 CML CML NNP cord-010119-t1x9gknd 1923 7 - - HYPH cord-010119-t1x9gknd 1923 8 AT AT NNP cord-010119-t1x9gknd 1923 9 pts pts NN cord-010119-t1x9gknd 1923 10 , , , cord-010119-t1x9gknd 1923 11 and and CC cord-010119-t1x9gknd 1924 1 plt plt NNP cord-010119-t1x9gknd 1924 2 ct ct NNP cord-010119-t1x9gknd 1924 3 < < NNP cord-010119-t1x9gknd 1924 4 450 450 CD cord-010119-t1x9gknd 1924 5 x x SYM cord-010119-t1x9gknd 1924 6 10 10 CD cord-010119-t1x9gknd 1924 7 9 9 CD cord-010119-t1x9gknd 1924 8 /L /L . cord-010119-t1x9gknd 1924 9 for for IN cord-010119-t1x9gknd 1924 10 symptomatic symptomatic JJ cord-010119-t1x9gknd 1924 11 ET ET NNP cord-010119-t1x9gknd 1924 12 pts pts NN cord-010119-t1x9gknd 1924 13 and and CC cord-010119-t1x9gknd 1924 14 < < XX cord-010119-t1x9gknd 1924 15 750 750 CD cord-010119-t1x9gknd 1924 16 x x SYM cord-010119-t1x9gknd 1924 17 10 10 CD cord-010119-t1x9gknd 1924 18 9 9 CD cord-010119-t1x9gknd 1924 19 /L /L . cord-010119-t1x9gknd 1924 20 for for IN cord-010119-t1x9gknd 1924 21 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 1924 22 ET ET NNP cord-010119-t1x9gknd 1924 23 pts pts NN cord-010119-t1x9gknd 1924 24 . . . cord-010119-t1x9gknd 1925 1 CML CML NNP cord-010119-t1x9gknd 1925 2 - - HYPH cord-010119-t1x9gknd 1925 3 AT AT NNP cord-010119-t1x9gknd 1925 4 pts pts NN cord-010119-t1x9gknd 1925 5 received receive VBD cord-010119-t1x9gknd 1925 6 median median NN cord-010119-t1x9gknd 1925 7 of of IN cord-010119-t1x9gknd 1925 8 3 3 CD cord-010119-t1x9gknd 1925 9 Lp Lp NNP cord-010119-t1x9gknd 1925 10 txs txs NNP cord-010119-t1x9gknd 1926 1 ( ( -LRB- cord-010119-t1x9gknd 1926 2 mean mean VB cord-010119-t1x9gknd 1926 3 3.9 3.9 CD cord-010119-t1x9gknd 1926 4 txs tx NNS cord-010119-t1x9gknd 1926 5 / / SYM cord-010119-t1x9gknd 1926 6 pt pt NN cord-010119-t1x9gknd 1926 7 ; ; : cord-010119-t1x9gknd 1927 1 range range NNP cord-010119-t1x9gknd 1927 2 2 2 CD cord-010119-t1x9gknd 1927 3 - - SYM cord-010119-t1x9gknd 1927 4 8 8 CD cord-010119-t1x9gknd 1927 5 txs tx NNS cord-010119-t1x9gknd 1927 6 ) ) -RRB- cord-010119-t1x9gknd 1927 7 . . . cord-010119-t1x9gknd 1928 1 ET ET NNP cord-010119-t1x9gknd 1928 2 pts pt NNS cord-010119-t1x9gknd 1928 3 underwent undergo VBD cord-010119-t1x9gknd 1928 4 median median NN cord-010119-t1x9gknd 1928 5 of of IN cord-010119-t1x9gknd 1928 6 2 2 CD cord-010119-t1x9gknd 1928 7 Tc Tc NNP cord-010119-t1x9gknd 1928 8 txs txs FW cord-010119-t1x9gknd 1928 9 ( ( -LRB- cord-010119-t1x9gknd 1928 10 mean mean VB cord-010119-t1x9gknd 1928 11 3.4 3.4 CD cord-010119-t1x9gknd 1928 12 txs tx NNS cord-010119-t1x9gknd 1928 13 / / SYM cord-010119-t1x9gknd 1928 14 pt pt NN cord-010119-t1x9gknd 1928 15 ; ; : cord-010119-t1x9gknd 1928 16 1 1 CD cord-010119-t1x9gknd 1928 17 - - SYM cord-010119-t1x9gknd 1928 18 7 7 CD cord-010119-t1x9gknd 1928 19 txs tx NNS cord-010119-t1x9gknd 1928 20 ) ) -RRB- cord-010119-t1x9gknd 1928 21 . . . cord-010119-t1x9gknd 1929 1 Outcomes outcome NNS cord-010119-t1x9gknd 1929 2 were be VBD cord-010119-t1x9gknd 1929 3 evaluated evaluate VBN cord-010119-t1x9gknd 1929 4 by by IN cord-010119-t1x9gknd 1929 5 percentage percentage NN cord-010119-t1x9gknd 1929 6 of of IN cord-010119-t1x9gknd 1929 7 pts pt NNS cord-010119-t1x9gknd 1929 8 who who WP cord-010119-t1x9gknd 1929 9 : : : cord-010119-t1x9gknd 1929 10 1 1 LS cord-010119-t1x9gknd 1929 11 ) ) -RRB- cord-010119-t1x9gknd 1929 12 reached reach VBD cord-010119-t1x9gknd 1929 13 WBC WBC NNP cord-010119-t1x9gknd 1929 14 ( ( -LRB- cord-010119-t1x9gknd 1929 15 or or CC cord-010119-t1x9gknd 1929 16 plt plt NNP cord-010119-t1x9gknd 1929 17 ct ct NNP cord-010119-t1x9gknd 1929 18 ) ) -RRB- cord-010119-t1x9gknd 1929 19 tx tx NNP cord-010119-t1x9gknd 1929 20 goal goal NNP cord-010119-t1x9gknd 1929 21 , , , cord-010119-t1x9gknd 1929 22 and and CC cord-010119-t1x9gknd 1929 23 2 2 LS cord-010119-t1x9gknd 1929 24 ) ) -RRB- cord-010119-t1x9gknd 1929 25 received receive VBD cord-010119-t1x9gknd 1929 26 ind ind NNP cord-010119-t1x9gknd 1929 27 chemo chemo NNP cord-010119-t1x9gknd 1929 28 . . . cord-010119-t1x9gknd 1930 1 " " `` cord-010119-t1x9gknd 1930 2 Improved improve VBN cord-010119-t1x9gknd 1930 3 " " '' cord-010119-t1x9gknd 1930 4 outcome outcome NN cord-010119-t1x9gknd 1930 5 was be VBD cord-010119-t1x9gknd 1930 6 defined define VBN cord-010119-t1x9gknd 1930 7 as as IN cord-010119-t1x9gknd 1930 8 pts pt NNS cord-010119-t1x9gknd 1930 9 who who WP cord-010119-t1x9gknd 1930 10 reached reach VBD cord-010119-t1x9gknd 1930 11 their -PRON- PRP$ cord-010119-t1x9gknd 1930 12 WBC WBC NNP cord-010119-t1x9gknd 1930 13 ( ( -LRB- cord-010119-t1x9gknd 1930 14 or or CC cord-010119-t1x9gknd 1930 15 plt plt NNP cord-010119-t1x9gknd 1930 16 ct ct NNP cord-010119-t1x9gknd 1930 17 ) ) -RRB- cord-010119-t1x9gknd 1930 18 tx tx NNP cord-010119-t1x9gknd 1930 19 goal goal NN cord-010119-t1x9gknd 1930 20 during during IN cord-010119-t1x9gknd 1930 21 CY CY NNP cord-010119-t1x9gknd 1930 22 tx tx NNP cord-010119-t1x9gknd 1930 23 ; ; : cord-010119-t1x9gknd 1930 24 " " `` cord-010119-t1x9gknd 1930 25 stabilized stabilize VBD cord-010119-t1x9gknd 1930 26 " " '' cord-010119-t1x9gknd 1930 27 were be VBD cord-010119-t1x9gknd 1930 28 pts pt NNS cord-010119-t1x9gknd 1930 29 who who WP cord-010119-t1x9gknd 1930 30 achieved achieve VBD cord-010119-t1x9gknd 1930 31 > > XX cord-010119-t1x9gknd 1930 32 50 50 CD cord-010119-t1x9gknd 1930 33 % % NN cord-010119-t1x9gknd 1930 34 reduction reduction NN cord-010119-t1x9gknd 1930 35 in in IN cord-010119-t1x9gknd 1930 36 WBC WBC NNP cord-010119-t1x9gknd 1930 37 ( ( -LRB- cord-010119-t1x9gknd 1930 38 or or CC cord-010119-t1x9gknd 1930 39 plt plt NNP cord-010119-t1x9gknd 1930 40 ct ct NNP cord-010119-t1x9gknd 1930 41 ) ) -RRB- cord-010119-t1x9gknd 1930 42 without without IN cord-010119-t1x9gknd 1930 43 reaching reach VBG cord-010119-t1x9gknd 1930 44 goal goal NN cord-010119-t1x9gknd 1930 45 ; ; : cord-010119-t1x9gknd 1930 46 and and CC cord-010119-t1x9gknd 1930 47 " " `` cord-010119-t1x9gknd 1930 48 unchanged unchanged JJ cord-010119-t1x9gknd 1930 49 " " '' cord-010119-t1x9gknd 1930 50 were be VBD cord-010119-t1x9gknd 1930 51 pts pt NNS cord-010119-t1x9gknd 1930 52 who who WP cord-010119-t1x9gknd 1930 53 achieved achieve VBD cord-010119-t1x9gknd 1930 54 neither neither RB cord-010119-t1x9gknd 1930 55 . . . cord-010119-t1x9gknd 1931 1 In in IN cord-010119-t1x9gknd 1931 2 CML CML NNP cord-010119-t1x9gknd 1931 3 - - HYPH cord-010119-t1x9gknd 1931 4 AT AT NNP cord-010119-t1x9gknd 1931 5 cohort cohort NN cord-010119-t1x9gknd 1931 6 , , , cord-010119-t1x9gknd 1931 7 76 76 CD cord-010119-t1x9gknd 1931 8 % % NN cord-010119-t1x9gknd 1931 9 pts pt NNS cord-010119-t1x9gknd 1931 10 improved improve VBN cord-010119-t1x9gknd 1931 11 , , , cord-010119-t1x9gknd 1931 12 21 21 CD cord-010119-t1x9gknd 1931 13 % % NN cord-010119-t1x9gknd 1931 14 pts pt NNS cord-010119-t1x9gknd 1931 15 stabilized stabilize VBN cord-010119-t1x9gknd 1931 16 ; ; : cord-010119-t1x9gknd 1931 17 and and CC cord-010119-t1x9gknd 1931 18 3 3 CD cord-010119-t1x9gknd 1931 19 % % NN cord-010119-t1x9gknd 1931 20 pts pt NNS cord-010119-t1x9gknd 1931 21 worsened worsen VBD cord-010119-t1x9gknd 1931 22 . . . cord-010119-t1x9gknd 1932 1 In in IN cord-010119-t1x9gknd 1932 2 ET ET NNP cord-010119-t1x9gknd 1932 3 cohort cohort NN cord-010119-t1x9gknd 1932 4 , , , cord-010119-t1x9gknd 1932 5 85 85 CD cord-010119-t1x9gknd 1932 6 % % NN cord-010119-t1x9gknd 1932 7 improved improve VBN cord-010119-t1x9gknd 1932 8 , , , cord-010119-t1x9gknd 1932 9 14 14 CD cord-010119-t1x9gknd 1932 10 % % NN cord-010119-t1x9gknd 1932 11 stabilized stabilize VBN cord-010119-t1x9gknd 1932 12 , , , cord-010119-t1x9gknd 1932 13 and and CC cord-010119-t1x9gknd 1932 14 1 1 CD cord-010119-t1x9gknd 1932 15 % % NN cord-010119-t1x9gknd 1932 16 were be VBD cord-010119-t1x9gknd 1932 17 unchanged unchanged JJ cord-010119-t1x9gknd 1932 18 . . . cord-010119-t1x9gknd 1933 1 For for IN cord-010119-t1x9gknd 1933 2 CML CML NNP cord-010119-t1x9gknd 1933 3 - - HYPH cord-010119-t1x9gknd 1933 4 AT AT NNP cord-010119-t1x9gknd 1933 5 pts pts NN cord-010119-t1x9gknd 1933 6 , , , cord-010119-t1x9gknd 1933 7 median median JJ cord-010119-t1x9gknd 1933 8 final final JJ cord-010119-t1x9gknd 1933 9 WBC WBC NNP cord-010119-t1x9gknd 1933 10 ct ct NNP cord-010119-t1x9gknd 1933 11 5 5 CD cord-010119-t1x9gknd 1934 1 96 96 CD cord-010119-t1x9gknd 1934 2 x x SYM cord-010119-t1x9gknd 1934 3 10 10 CD cord-010119-t1x9gknd 1934 4 9 9 CD cord-010119-t1x9gknd 1934 5 /L /L . cord-010119-t1x9gknd 1934 6 ( ( -LRB- cord-010119-t1x9gknd 1934 7 range range NN cord-010119-t1x9gknd 1934 8 66 66 CD cord-010119-t1x9gknd 1934 9 - - SYM cord-010119-t1x9gknd 1934 10 307 307 CD cord-010119-t1x9gknd 1934 11 x x SYM cord-010119-t1x9gknd 1934 12 10 10 CD cord-010119-t1x9gknd 1934 13 9 9 CD cord-010119-t1x9gknd 1934 14 /L /l CD cord-010119-t1x9gknd 1934 15 ) ) -RRB- cord-010119-t1x9gknd 1934 16 ; ; : cord-010119-t1x9gknd 1935 1 94 94 CD cord-010119-t1x9gknd 1935 2 % % NN cord-010119-t1x9gknd 1935 3 pts pt NNS cord-010119-t1x9gknd 1935 4 received receive VBD cord-010119-t1x9gknd 1935 5 ind ind NNP cord-010119-t1x9gknd 1935 6 chemo chemo NNP cord-010119-t1x9gknd 1935 7 . . . cord-010119-t1x9gknd 1936 1 For for IN cord-010119-t1x9gknd 1936 2 ET ET NNP cord-010119-t1x9gknd 1936 3 pts pts NN cord-010119-t1x9gknd 1936 4 , , , cord-010119-t1x9gknd 1936 5 median median JJ cord-010119-t1x9gknd 1936 6 final final JJ cord-010119-t1x9gknd 1936 7 plt plt NNP cord-010119-t1x9gknd 1936 8 ct ct NNP cord-010119-t1x9gknd 1936 9 5 5 CD cord-010119-t1x9gknd 1936 10 705 705 CD cord-010119-t1x9gknd 1936 11 x x SYM cord-010119-t1x9gknd 1936 12 10 10 CD cord-010119-t1x9gknd 1936 13 9 9 CD cord-010119-t1x9gknd 1936 14 /L /L . cord-010119-t1x9gknd 1936 15 ( ( -LRB- cord-010119-t1x9gknd 1936 16 263 263 CD cord-010119-t1x9gknd 1936 17 - - SYM cord-010119-t1x9gknd 1936 18 1087 1087 CD cord-010119-t1x9gknd 1936 19 x x SYM cord-010119-t1x9gknd 1936 20 10 10 CD cord-010119-t1x9gknd 1936 21 9 9 CD cord-010119-t1x9gknd 1936 22 /L /l CD cord-010119-t1x9gknd 1936 23 ) ) -RRB- cord-010119-t1x9gknd 1936 24 ; ; : cord-010119-t1x9gknd 1936 25 95 95 CD cord-010119-t1x9gknd 1936 26 % % NN cord-010119-t1x9gknd 1936 27 pts pts NN cord-010119-t1x9gknd 1936 28 had have VBD cord-010119-t1x9gknd 1936 29 resolution resolution NN cord-010119-t1x9gknd 1936 30 of of IN cord-010119-t1x9gknd 1936 31 thrombotic thrombotic JJ cord-010119-t1x9gknd 1936 32 49A 49a CD cord-010119-t1x9gknd 1936 33 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 1936 34 2017 2017 CD cord-010119-t1x9gknd 1936 35 Vol Vol NNP cord-010119-t1x9gknd 1936 36 . . . cord-010119-t1x9gknd 1937 1 57 57 CD cord-010119-t1x9gknd 1937 2 Supplement supplement NN cord-010119-t1x9gknd 1937 3 S3 S3 NNP cord-010119-t1x9gknd 1937 4 symptoms symptom NNS cord-010119-t1x9gknd 1937 5 . . . cord-010119-t1x9gknd 1938 1 4 4 CD cord-010119-t1x9gknd 1938 2 % % NN cord-010119-t1x9gknd 1938 3 of of IN cord-010119-t1x9gknd 1938 4 CML CML NNP cord-010119-t1x9gknd 1938 5 - - HYPH cord-010119-t1x9gknd 1938 6 AT AT NNP cord-010119-t1x9gknd 1938 7 pts pts NN cord-010119-t1x9gknd 1938 8 and and CC cord-010119-t1x9gknd 1938 9 0 0 CD cord-010119-t1x9gknd 1938 10 % % NN cord-010119-t1x9gknd 1938 11 of of IN cord-010119-t1x9gknd 1938 12 ET ET NNP cord-010119-t1x9gknd 1938 13 pts pt NNS cord-010119-t1x9gknd 1938 14 expired expire VBD cord-010119-t1x9gknd 1938 15 within within IN cord-010119-t1x9gknd 1938 16 1 1 CD cord-010119-t1x9gknd 1938 17 - - SYM cord-010119-t1x9gknd 1938 18 4 4 CD cord-010119-t1x9gknd 1938 19 days day NNS cord-010119-t1x9gknd 1938 20 after after IN cord-010119-t1x9gknd 1938 21 course course NN cord-010119-t1x9gknd 1938 22 of of IN cord-010119-t1x9gknd 1938 23 CY CY NNP cord-010119-t1x9gknd 1938 24 tx tx NNP cord-010119-t1x9gknd 1938 25 . . . cord-010119-t1x9gknd 1939 1 Of of IN cord-010119-t1x9gknd 1939 2 3 3 CD cord-010119-t1x9gknd 1939 3 expired expire VBD cord-010119-t1x9gknd 1939 4 pts pts NN cord-010119-t1x9gknd 1939 5 , , , cord-010119-t1x9gknd 1939 6 2 2 CD cord-010119-t1x9gknd 1939 7 pts pt NNS cord-010119-t1x9gknd 1939 8 had have VBD cord-010119-t1x9gknd 1939 9 both both DT cord-010119-t1x9gknd 1939 10 blast blast NN cord-010119-t1x9gknd 1939 11 crisis crisis NN cord-010119-t1x9gknd 1939 12 and and CC cord-010119-t1x9gknd 1939 13 sxs sxs NNP cord-010119-t1x9gknd 1939 14 of of IN cord-010119-t1x9gknd 1939 15 CNS/ CNS/ NNP cord-010119-t1x9gknd 1939 16 pulm pulm NN cord-010119-t1x9gknd 1939 17 lks lks NNP cord-010119-t1x9gknd 1940 1 ; ; : cord-010119-t1x9gknd 1940 2 1 1 CD cord-010119-t1x9gknd 1940 3 pt pt NN cord-010119-t1x9gknd 1940 4 had have VBD cord-010119-t1x9gknd 1940 5 intracranial intracranial JJ cord-010119-t1x9gknd 1940 6 hemorrhage hemorrhage NN cord-010119-t1x9gknd 1940 7 or or CC cord-010119-t1x9gknd 1940 8 CVA CVA NNP cord-010119-t1x9gknd 1940 9 ; ; : cord-010119-t1x9gknd 1940 10 and and CC cord-010119-t1x9gknd 1940 11 2 2 CD cord-010119-t1x9gknd 1940 12 pts pt NNS cord-010119-t1x9gknd 1940 13 were be VBD cord-010119-t1x9gknd 1940 14 hypotensive hypotensive JJ cord-010119-t1x9gknd 1940 15 , , , cord-010119-t1x9gknd 1940 16 intubated intubate VBN cord-010119-t1x9gknd 1940 17 , , , cord-010119-t1x9gknd 1940 18 or or CC cord-010119-t1x9gknd 1940 19 unable unable JJ cord-010119-t1x9gknd 1940 20 to to TO cord-010119-t1x9gknd 1940 21 tolerate tolerate VB cord-010119-t1x9gknd 1940 22 ind ind NNP cord-010119-t1x9gknd 1940 23 chemo chemo NNP cord-010119-t1x9gknd 1940 24 . . . cord-010119-t1x9gknd 1941 1 Conclusion conclusion NN cord-010119-t1x9gknd 1941 2 : : : cord-010119-t1x9gknd 1942 1 Pts Pts NNP cord-010119-t1x9gknd 1942 2 with with IN cord-010119-t1x9gknd 1942 3 CML CML NNP cord-010119-t1x9gknd 1942 4 - - HYPH cord-010119-t1x9gknd 1942 5 AT AT NNP cord-010119-t1x9gknd 1942 6 or or CC cord-010119-t1x9gknd 1942 7 ET ET NNP cord-010119-t1x9gknd 1942 8 and and CC cord-010119-t1x9gknd 1942 9 evidence evidence NN cord-010119-t1x9gknd 1942 10 of of IN cord-010119-t1x9gknd 1942 11 impending impend VBG cord-010119-t1x9gknd 1942 12 thrombosis thrombosis NN cord-010119-t1x9gknd 1942 13 may may MD cord-010119-t1x9gknd 1942 14 benefit benefit VB cord-010119-t1x9gknd 1942 15 from from IN cord-010119-t1x9gknd 1942 16 cytoreductive cytoreductive JJ cord-010119-t1x9gknd 1942 17 therapy therapy NN cord-010119-t1x9gknd 1942 18 . . . cord-010119-t1x9gknd 1943 1 A a DT cord-010119-t1x9gknd 1943 2 limited limited JJ cord-010119-t1x9gknd 1943 3 number number NN cord-010119-t1x9gknd 1943 4 of of IN cord-010119-t1x9gknd 1943 5 cytapheresis cytapheresis NN cord-010119-t1x9gknd 1943 6 treatments treatment NNS cord-010119-t1x9gknd 1943 7 ( ( -LRB- cord-010119-t1x9gknd 1943 8 median median JJ cord-010119-t1x9gknd 1943 9 2 2 CD cord-010119-t1x9gknd 1943 10 - - SYM cord-010119-t1x9gknd 1943 11 3 3 CD cord-010119-t1x9gknd 1943 12 txs tx NNS cord-010119-t1x9gknd 1943 13 ) ) -RRB- cord-010119-t1x9gknd 1943 14 can can MD cord-010119-t1x9gknd 1943 15 enable enable VB cord-010119-t1x9gknd 1943 16 a a DT cord-010119-t1x9gknd 1943 17 high high JJ cord-010119-t1x9gknd 1943 18 percentage percentage NN cord-010119-t1x9gknd 1943 19 of of IN cord-010119-t1x9gknd 1943 20 pts pts NN cord-010119-t1x9gknd 1943 21 to to TO cord-010119-t1x9gknd 1943 22 receive receive VB cord-010119-t1x9gknd 1943 23 definitive definitive JJ cord-010119-t1x9gknd 1943 24 treatment treatment NN cord-010119-t1x9gknd 1943 25 and and CC cord-010119-t1x9gknd 1943 26 may may MD cord-010119-t1x9gknd 1943 27 improve improve VB cord-010119-t1x9gknd 1943 28 short short JJ cord-010119-t1x9gknd 1943 29 - - HYPH cord-010119-t1x9gknd 1943 30 term term NN cord-010119-t1x9gknd 1943 31 clinical clinical JJ cord-010119-t1x9gknd 1943 32 outcomes outcome NNS cord-010119-t1x9gknd 1943 33 . . . cord-010119-t1x9gknd 1944 1 A a DT cord-010119-t1x9gknd 1944 2 RCT RCT NNP cord-010119-t1x9gknd 1944 3 to to TO cord-010119-t1x9gknd 1944 4 assess assess VB cord-010119-t1x9gknd 1944 5 efficacy efficacy NN cord-010119-t1x9gknd 1944 6 of of IN cord-010119-t1x9gknd 1944 7 cytapheresis cytapheresis NN cord-010119-t1x9gknd 1944 8 treatment treatment NN cord-010119-t1x9gknd 1944 9 versus versus IN cord-010119-t1x9gknd 1944 10 induction induction NN cord-010119-t1x9gknd 1944 11 chemotherapy chemotherapy NN cord-010119-t1x9gknd 1944 12 ( ( -LRB- cord-010119-t1x9gknd 1944 13 or or CC cord-010119-t1x9gknd 1944 14 platelet platelet NN cord-010119-t1x9gknd 1944 15 inhibitor inhibitor NN cord-010119-t1x9gknd 1944 16 tx tx NNP cord-010119-t1x9gknd 1944 17 ) ) -RRB- cord-010119-t1x9gknd 1945 1 alone alone RB cord-010119-t1x9gknd 1945 2 in in IN cord-010119-t1x9gknd 1945 3 this this DT cord-010119-t1x9gknd 1945 4 subset subset NN cord-010119-t1x9gknd 1945 5 of of IN cord-010119-t1x9gknd 1945 6 pts pts NN cord-010119-t1x9gknd 1945 7 would would MD cord-010119-t1x9gknd 1945 8 be be VB cord-010119-t1x9gknd 1945 9 very very RB cord-010119-t1x9gknd 1945 10 useful useful JJ cord-010119-t1x9gknd 1945 11 . . . cord-010119-t1x9gknd 1946 1 Background Background NNP cord-010119-t1x9gknd 1946 2 / / SYM cord-010119-t1x9gknd 1946 3 Case Case NNP cord-010119-t1x9gknd 1946 4 Studies Studies NNPS cord-010119-t1x9gknd 1946 5 : : : cord-010119-t1x9gknd 1947 1 Partial partial JJ cord-010119-t1x9gknd 1947 2 normal normal JJ cord-010119-t1x9gknd 1947 3 saline saline NN cord-010119-t1x9gknd 1947 4 replacement replacement NN cord-010119-t1x9gknd 1947 5 during during IN cord-010119-t1x9gknd 1947 6 plasma plasma NN cord-010119-t1x9gknd 1947 7 exchange exchange NN cord-010119-t1x9gknd 1947 8 procedures procedure NNS cord-010119-t1x9gknd 1947 9 is be VBZ cord-010119-t1x9gknd 1947 10 common common JJ cord-010119-t1x9gknd 1947 11 practice practice NN cord-010119-t1x9gknd 1947 12 . . . cord-010119-t1x9gknd 1948 1 Benefits benefit NNS cord-010119-t1x9gknd 1948 2 of of IN cord-010119-t1x9gknd 1948 3 using use VBG cord-010119-t1x9gknd 1948 4 normal normal JJ cord-010119-t1x9gknd 1948 5 saline saline NN cord-010119-t1x9gknd 1948 6 as as IN cord-010119-t1x9gknd 1948 7 a a DT cord-010119-t1x9gknd 1948 8 replacement replacement NN cord-010119-t1x9gknd 1948 9 fluid fluid NN cord-010119-t1x9gknd 1948 10 include include VBP cord-010119-t1x9gknd 1948 11 reduced reduce VBN cord-010119-t1x9gknd 1948 12 procedure procedure NN cord-010119-t1x9gknd 1948 13 costs cost NNS cord-010119-t1x9gknd 1948 14 and and CC cord-010119-t1x9gknd 1948 15 possible possible JJ cord-010119-t1x9gknd 1948 16 reduction reduction NN cord-010119-t1x9gknd 1948 17 of of IN cord-010119-t1x9gknd 1948 18 the the DT cord-010119-t1x9gknd 1948 19 hypothetical hypothetical JJ cord-010119-t1x9gknd 1948 20 hyper hyper JJ cord-010119-t1x9gknd 1948 21 - - JJ cord-010119-t1x9gknd 1948 22 oncotic oncotic JJ cord-010119-t1x9gknd 1948 23 effects effect NNS cord-010119-t1x9gknd 1948 24 of of IN cord-010119-t1x9gknd 1948 25 standard standard JJ cord-010119-t1x9gknd 1948 26 albumin albumin NN cord-010119-t1x9gknd 1948 27 formulations formulation NNS cord-010119-t1x9gknd 1948 28 . . . cord-010119-t1x9gknd 1949 1 However however RB cord-010119-t1x9gknd 1949 2 , , , cord-010119-t1x9gknd 1949 3 the the DT cord-010119-t1x9gknd 1949 4 use use NN cord-010119-t1x9gknd 1949 5 of of IN cord-010119-t1x9gknd 1949 6 normal normal JJ cord-010119-t1x9gknd 1949 7 saline saline NN cord-010119-t1x9gknd 1949 8 may may MD cord-010119-t1x9gknd 1949 9 increase increase VB cord-010119-t1x9gknd 1949 10 the the DT cord-010119-t1x9gknd 1949 11 risk risk NN cord-010119-t1x9gknd 1949 12 of of IN cord-010119-t1x9gknd 1949 13 undesired undesired JJ cord-010119-t1x9gknd 1949 14 , , , cord-010119-t1x9gknd 1949 15 and and CC cord-010119-t1x9gknd 1949 16 potentially potentially RB cord-010119-t1x9gknd 1949 17 costly costly JJ cord-010119-t1x9gknd 1949 18 , , , cord-010119-t1x9gknd 1949 19 adverse adverse JJ cord-010119-t1x9gknd 1949 20 events event NNS cord-010119-t1x9gknd 1949 21 , , , cord-010119-t1x9gknd 1949 22 such such JJ cord-010119-t1x9gknd 1949 23 as as IN cord-010119-t1x9gknd 1949 24 hypotension hypotension NN cord-010119-t1x9gknd 1949 25 and and CC cord-010119-t1x9gknd 1949 26 citrate citrate NN cord-010119-t1x9gknd 1949 27 reactions reaction NNS cord-010119-t1x9gknd 1949 28 . . . cord-010119-t1x9gknd 1950 1 The the DT cord-010119-t1x9gknd 1950 2 goal goal NN cord-010119-t1x9gknd 1950 3 of of IN cord-010119-t1x9gknd 1950 4 this this DT cord-010119-t1x9gknd 1950 5 study study NN cord-010119-t1x9gknd 1950 6 was be VBD cord-010119-t1x9gknd 1950 7 to to TO cord-010119-t1x9gknd 1950 8 compare compare VB cord-010119-t1x9gknd 1950 9 the the DT cord-010119-t1x9gknd 1950 10 frequency frequency NN cord-010119-t1x9gknd 1950 11 of of IN cord-010119-t1x9gknd 1950 12 reported report VBN cord-010119-t1x9gknd 1950 13 adverse adverse JJ cord-010119-t1x9gknd 1950 14 outcomes outcome NNS cord-010119-t1x9gknd 1950 15 for for IN cord-010119-t1x9gknd 1950 16 patients patient NNS cord-010119-t1x9gknd 1950 17 that that WDT cord-010119-t1x9gknd 1950 18 received receive VBD cord-010119-t1x9gknd 1950 19 all all DT cord-010119-t1x9gknd 1950 20 albumin albumin NN cord-010119-t1x9gknd 1950 21 versus versus IN cord-010119-t1x9gknd 1950 22 albumin/ albumin/ CD cord-010119-t1x9gknd 1950 23 saline saline NN cord-010119-t1x9gknd 1950 24 as as IN cord-010119-t1x9gknd 1950 25 replacement replacement NN cord-010119-t1x9gknd 1950 26 fluid fluid NN cord-010119-t1x9gknd 1950 27 for for IN cord-010119-t1x9gknd 1950 28 plasma plasma NN cord-010119-t1x9gknd 1950 29 exchange exchange NN cord-010119-t1x9gknd 1950 30 at at IN cord-010119-t1x9gknd 1950 31 our -PRON- PRP$ cord-010119-t1x9gknd 1950 32 institution institution NN cord-010119-t1x9gknd 1950 33 . . . cord-010119-t1x9gknd 1951 1 Study Study NNP cord-010119-t1x9gknd 1951 2 Design Design NNP cord-010119-t1x9gknd 1951 3 / / SYM cord-010119-t1x9gknd 1951 4 Method method NN cord-010119-t1x9gknd 1951 5 : : : cord-010119-t1x9gknd 1952 1 A a DT cord-010119-t1x9gknd 1952 2 four four CD cord-010119-t1x9gknd 1952 3 year year NN cord-010119-t1x9gknd 1952 4 retrospective retrospective JJ cord-010119-t1x9gknd 1952 5 chart chart NN cord-010119-t1x9gknd 1952 6 review review NN cord-010119-t1x9gknd 1952 7 was be VBD cord-010119-t1x9gknd 1952 8 done do VBN cord-010119-t1x9gknd 1952 9 of of IN cord-010119-t1x9gknd 1952 10 all all DT cord-010119-t1x9gknd 1952 11 therapeutic therapeutic JJ cord-010119-t1x9gknd 1952 12 apheresis apheresis NN cord-010119-t1x9gknd 1952 13 procedures procedure NNS cord-010119-t1x9gknd 1952 14 performed perform VBN cord-010119-t1x9gknd 1952 15 by by IN cord-010119-t1x9gknd 1952 16 our -PRON- PRP$ cord-010119-t1x9gknd 1952 17 apheresis apheresis NN cord-010119-t1x9gknd 1952 18 service service NN cord-010119-t1x9gknd 1952 19 that that WDT cord-010119-t1x9gknd 1952 20 used use VBD cord-010119-t1x9gknd 1952 21 100 100 CD cord-010119-t1x9gknd 1952 22 % % NN cord-010119-t1x9gknd 1952 23 albumin albumin NN cord-010119-t1x9gknd 1952 24 or or CC cord-010119-t1x9gknd 1952 25 80 80 CD cord-010119-t1x9gknd 1952 26 % % NN cord-010119-t1x9gknd 1952 27 albumin-20 albumin-20 CD cord-010119-t1x9gknd 1952 28 % % NN cord-010119-t1x9gknd 1952 29 normal normal JJ cord-010119-t1x9gknd 1952 30 saline saline NN cord-010119-t1x9gknd 1952 31 ( ( -LRB- cord-010119-t1x9gknd 1952 32 80/20 80/20 CD cord-010119-t1x9gknd 1952 33 ) ) -RRB- cord-010119-t1x9gknd 1952 34 as as IN cord-010119-t1x9gknd 1952 35 replacement replacement NN cord-010119-t1x9gknd 1952 36 . . . cord-010119-t1x9gknd 1953 1 Patients patient NNS cord-010119-t1x9gknd 1953 2 who who WP cord-010119-t1x9gknd 1953 3 received receive VBD cord-010119-t1x9gknd 1953 4 plasma plasma NN cord-010119-t1x9gknd 1953 5 entirely entirely RB cord-010119-t1x9gknd 1953 6 or or CC cord-010119-t1x9gknd 1953 7 partially partially RB cord-010119-t1x9gknd 1953 8 as as IN cord-010119-t1x9gknd 1953 9 replacement replacement NN cord-010119-t1x9gknd 1953 10 were be VBD cord-010119-t1x9gknd 1953 11 excluded exclude VBN cord-010119-t1x9gknd 1953 12 . . . cord-010119-t1x9gknd 1954 1 The the DT cord-010119-t1x9gknd 1954 2 procedure procedure NN cord-010119-t1x9gknd 1954 3 type type NN cord-010119-t1x9gknd 1954 4 ordered order VBN cord-010119-t1x9gknd 1954 5 ( ( -LRB- cord-010119-t1x9gknd 1954 6 100 100 CD cord-010119-t1x9gknd 1954 7 % % NN cord-010119-t1x9gknd 1954 8 albumin albumin NN cord-010119-t1x9gknd 1954 9 vs vs IN cord-010119-t1x9gknd 1954 10 80/20 80/20 CD cord-010119-t1x9gknd 1954 11 ) ) -RRB- cord-010119-t1x9gknd 1954 12 , , , cord-010119-t1x9gknd 1954 13 the the DT cord-010119-t1x9gknd 1954 14 percent percent NN cord-010119-t1x9gknd 1954 15 of of IN cord-010119-t1x9gknd 1954 16 normal normal JJ cord-010119-t1x9gknd 1954 17 saline saline NN cord-010119-t1x9gknd 1954 18 actually actually RB cord-010119-t1x9gknd 1954 19 used use VBN cord-010119-t1x9gknd 1954 20 during during IN cord-010119-t1x9gknd 1954 21 the the DT cord-010119-t1x9gknd 1954 22 procedure procedure NN cord-010119-t1x9gknd 1954 23 , , , cord-010119-t1x9gknd 1954 24 age age NN cord-010119-t1x9gknd 1954 25 , , , cord-010119-t1x9gknd 1954 26 gender gender NN cord-010119-t1x9gknd 1954 27 , , , cord-010119-t1x9gknd 1954 28 and and CC cord-010119-t1x9gknd 1954 29 any any DT cord-010119-t1x9gknd 1954 30 noted note VBD cord-010119-t1x9gknd 1954 31 adverse adverse JJ cord-010119-t1x9gknd 1954 32 events event NNS cord-010119-t1x9gknd 1954 33 during during IN cord-010119-t1x9gknd 1954 34 the the DT cord-010119-t1x9gknd 1954 35 procedure procedure NN cord-010119-t1x9gknd 1954 36 were be VBD cord-010119-t1x9gknd 1954 37 recorded record VBN cord-010119-t1x9gknd 1954 38 in in IN cord-010119-t1x9gknd 1954 39 all all DT cord-010119-t1x9gknd 1954 40 cases case NNS cord-010119-t1x9gknd 1954 41 . . . cord-010119-t1x9gknd 1955 1 Repeated repeat VBN cord-010119-t1x9gknd 1955 2 procedures procedure NNS cord-010119-t1x9gknd 1955 3 were be VBD cord-010119-t1x9gknd 1955 4 modeled model VBN cord-010119-t1x9gknd 1955 5 using use VBG cord-010119-t1x9gknd 1955 6 a a DT cord-010119-t1x9gknd 1955 7 generalized generalized JJ cord-010119-t1x9gknd 1955 8 linear linear JJ cord-010119-t1x9gknd 1955 9 mixed mixed JJ cord-010119-t1x9gknd 1955 10 model model NN cord-010119-t1x9gknd 1955 11 to to TO cord-010119-t1x9gknd 1955 12 examine examine VB cord-010119-t1x9gknd 1955 13 the the DT cord-010119-t1x9gknd 1955 14 risk risk NN cord-010119-t1x9gknd 1955 15 of of IN cord-010119-t1x9gknd 1955 16 having have VBG cord-010119-t1x9gknd 1955 17 hypotension hypotension NN cord-010119-t1x9gknd 1955 18 and/or and/or CC cord-010119-t1x9gknd 1955 19 citrate citrate NN cord-010119-t1x9gknd 1955 20 toxicity toxicity NN cord-010119-t1x9gknd 1955 21 where where WRB cord-010119-t1x9gknd 1955 22 100 100 CD cord-010119-t1x9gknd 1955 23 % % NN cord-010119-t1x9gknd 1955 24 albumin albumin NN cord-010119-t1x9gknd 1955 25 was be VBD cord-010119-t1x9gknd 1955 26 used use VBN cord-010119-t1x9gknd 1955 27 versus versus IN cord-010119-t1x9gknd 1955 28 those those DT cord-010119-t1x9gknd 1955 29 that that WDT cord-010119-t1x9gknd 1955 30 used use VBD cord-010119-t1x9gknd 1955 31 80/20 80/20 CD cord-010119-t1x9gknd 1955 32 . . . cord-010119-t1x9gknd 1956 1 Covariates covariate NNS cord-010119-t1x9gknd 1956 2 included include VBD cord-010119-t1x9gknd 1956 3 were be VBD cord-010119-t1x9gknd 1956 4 fluid fluid JJ cord-010119-t1x9gknd 1956 5 types type NNS cord-010119-t1x9gknd 1956 6 , , , cord-010119-t1x9gknd 1956 7 age age NN cord-010119-t1x9gknd 1956 8 and and CC cord-010119-t1x9gknd 1956 9 gender gender NN cord-010119-t1x9gknd 1956 10 . . . cord-010119-t1x9gknd 1957 1 Odds odd NNS cord-010119-t1x9gknd 1957 2 ratios ratio NNS cord-010119-t1x9gknd 1957 3 ( ( -LRB- cord-010119-t1x9gknd 1957 4 OR or CC cord-010119-t1x9gknd 1957 5 ) ) -RRB- cord-010119-t1x9gknd 1957 6 and and CC cord-010119-t1x9gknd 1957 7 95 95 CD cord-010119-t1x9gknd 1957 8 % % NN cord-010119-t1x9gknd 1957 9 confidence confidence NN cord-010119-t1x9gknd 1957 10 intervals interval NNS cord-010119-t1x9gknd 1957 11 ( ( -LRB- cord-010119-t1x9gknd 1957 12 CI CI NNP cord-010119-t1x9gknd 1957 13 ) ) -RRB- cord-010119-t1x9gknd 1957 14 were be VBD cord-010119-t1x9gknd 1957 15 used use VBN cord-010119-t1x9gknd 1957 16 as as IN cord-010119-t1x9gknd 1957 17 a a DT cord-010119-t1x9gknd 1957 18 measure measure NN cord-010119-t1x9gknd 1957 19 of of IN cord-010119-t1x9gknd 1957 20 risk risk NN cord-010119-t1x9gknd 1957 21 . . . cord-010119-t1x9gknd 1958 1 We -PRON- PRP cord-010119-t1x9gknd 1958 2 used use VBD cord-010119-t1x9gknd 1958 3 the the DT cord-010119-t1x9gknd 1958 4 term term NN cord-010119-t1x9gknd 1958 5 significant significant JJ cord-010119-t1x9gknd 1958 6 for for IN cord-010119-t1x9gknd 1958 7 a a DT cord-010119-t1x9gknd 1958 8 two two CD cord-010119-t1x9gknd 1958 9 - - HYPH cord-010119-t1x9gknd 1958 10 sided sided JJ cord-010119-t1x9gknd 1958 11 p p NN cord-010119-t1x9gknd 1958 12 - - HYPH cord-010119-t1x9gknd 1958 13 value value NN cord-010119-t1x9gknd 1958 14 < < XX cord-010119-t1x9gknd 1958 15 0.05 0.05 CD cord-010119-t1x9gknd 1958 16 . . . cord-010119-t1x9gknd 1959 1 Results result NNS cord-010119-t1x9gknd 1959 2 / / SYM cord-010119-t1x9gknd 1959 3 Finding finding NN cord-010119-t1x9gknd 1959 4 : : : cord-010119-t1x9gknd 1960 1 During during IN cord-010119-t1x9gknd 1960 2 the the DT cord-010119-t1x9gknd 1960 3 study study NN cord-010119-t1x9gknd 1960 4 period period NN cord-010119-t1x9gknd 1960 5 , , , cord-010119-t1x9gknd 1960 6 3650 3650 CD cord-010119-t1x9gknd 1960 7 procedures procedure NNS cord-010119-t1x9gknd 1960 8 were be VBD cord-010119-t1x9gknd 1960 9 documented document VBN cord-010119-t1x9gknd 1960 10 for for IN cord-010119-t1x9gknd 1960 11 414 414 CD cord-010119-t1x9gknd 1960 12 subjects subject NNS cord-010119-t1x9gknd 1960 13 ( ( -LRB- cord-010119-t1x9gknd 1960 14 46 46 CD cord-010119-t1x9gknd 1960 15 % % NN cord-010119-t1x9gknd 1960 16 female female NN cord-010119-t1x9gknd 1960 17 ) ) -RRB- cord-010119-t1x9gknd 1960 18 , , , cord-010119-t1x9gknd 1960 19 age age NN cord-010119-t1x9gknd 1960 20 range range NN cord-010119-t1x9gknd 1960 21 0 0 CD cord-010119-t1x9gknd 1960 22 - - HYPH cord-010119-t1x9gknd 1960 23 93 93 CD cord-010119-t1x9gknd 1960 24 years year NNS cord-010119-t1x9gknd 1960 25 , , , cord-010119-t1x9gknd 1960 26 of of IN cord-010119-t1x9gknd 1960 27 which which WDT cord-010119-t1x9gknd 1960 28 2,470 2,470 CD cord-010119-t1x9gknd 1960 29 ( ( -LRB- cord-010119-t1x9gknd 1960 30 67.7 67.7 CD cord-010119-t1x9gknd 1960 31 % % NN cord-010119-t1x9gknd 1960 32 ) ) -RRB- cord-010119-t1x9gknd 1960 33 received receive VBD cord-010119-t1x9gknd 1960 34 80/20 80/20 CD cord-010119-t1x9gknd 1960 35 . . . cord-010119-t1x9gknd 1961 1 The the DT cord-010119-t1x9gknd 1961 2 type type NN cord-010119-t1x9gknd 1961 3 of of IN cord-010119-t1x9gknd 1961 4 fluid fluid NN cord-010119-t1x9gknd 1961 5 used use VBN cord-010119-t1x9gknd 1961 6 as as IN cord-010119-t1x9gknd 1961 7 replacement replacement NN cord-010119-t1x9gknd 1961 8 had have VBD cord-010119-t1x9gknd 1961 9 a a DT cord-010119-t1x9gknd 1961 10 significant significant JJ cord-010119-t1x9gknd 1961 11 effect effect NN cord-010119-t1x9gknd 1961 12 on on IN cord-010119-t1x9gknd 1961 13 the the DT cord-010119-t1x9gknd 1961 14 risk risk NN cord-010119-t1x9gknd 1961 15 of of IN cord-010119-t1x9gknd 1961 16 having have VBG cord-010119-t1x9gknd 1961 17 either either CC cord-010119-t1x9gknd 1961 18 hypotension hypotension NN cord-010119-t1x9gknd 1961 19 or or CC cord-010119-t1x9gknd 1961 20 citrate citrate NN cord-010119-t1x9gknd 1961 21 toxicity toxicity NN cord-010119-t1x9gknd 1961 22 . . . cord-010119-t1x9gknd 1962 1 Replacement replacement NN cord-010119-t1x9gknd 1962 2 with with IN cord-010119-t1x9gknd 1962 3 100 100 CD cord-010119-t1x9gknd 1962 4 % % NN cord-010119-t1x9gknd 1962 5 albumin albumin NN cord-010119-t1x9gknd 1962 6 had have VBD cord-010119-t1x9gknd 1962 7 a a DT cord-010119-t1x9gknd 1962 8 significantly significantly RB cord-010119-t1x9gknd 1962 9 lower low JJR cord-010119-t1x9gknd 1962 10 risk risk NN cord-010119-t1x9gknd 1962 11 of of IN cord-010119-t1x9gknd 1962 12 having have VBG cord-010119-t1x9gknd 1962 13 either either DT cord-010119-t1x9gknd 1962 14 event event NN cord-010119-t1x9gknd 1962 15 than than IN cord-010119-t1x9gknd 1962 16 by by IN cord-010119-t1x9gknd 1962 17 using use VBG cord-010119-t1x9gknd 1962 18 80/20 80/20 CD cord-010119-t1x9gknd 1962 19 , , , cord-010119-t1x9gknd 1962 20 [ [ -LRB- cord-010119-t1x9gknd 1962 21 p50.002 p50.002 UH cord-010119-t1x9gknd 1962 22 , , , cord-010119-t1x9gknd 1962 23 OR or CC cord-010119-t1x9gknd 1962 24 ( ( -LRB- cord-010119-t1x9gknd 1962 25 CI CI NNP cord-010119-t1x9gknd 1962 26 ) ) -RRB- cord-010119-t1x9gknd 1962 27 : : : cord-010119-t1x9gknd 1962 28 0.40(0.22 0.40(0.22 CD cord-010119-t1x9gknd 1962 29 , , , cord-010119-t1x9gknd 1962 30 0.72 0.72 CD cord-010119-t1x9gknd 1962 31 ) ) -RRB- cord-010119-t1x9gknd 1962 32 ] ] -RRB- cord-010119-t1x9gknd 1962 33 , , , cord-010119-t1x9gknd 1962 34 and and CC cord-010119-t1x9gknd 1962 35 also also RB cord-010119-t1x9gknd 1962 36 had have VBD cord-010119-t1x9gknd 1962 37 a a DT cord-010119-t1x9gknd 1962 38 significantly significantly RB cord-010119-t1x9gknd 1962 39 lower low JJR cord-010119-t1x9gknd 1962 40 risk risk NN cord-010119-t1x9gknd 1962 41 of of IN cord-010119-t1x9gknd 1962 42 causing cause VBG cord-010119-t1x9gknd 1962 43 hypotension hypotension NN cord-010119-t1x9gknd 1962 44 [ [ -LRB- cord-010119-t1x9gknd 1962 45 p50.023 p50.023 XX cord-010119-t1x9gknd 1962 46 , , , cord-010119-t1x9gknd 1963 1 OR or CC cord-010119-t1x9gknd 1963 2 ( ( -LRB- cord-010119-t1x9gknd 1963 3 CI):0.45 CI):0.45 NNP cord-010119-t1x9gknd 1963 4 ( ( -LRB- cord-010119-t1x9gknd 1963 5 0.22 0.22 CD cord-010119-t1x9gknd 1963 6 , , , cord-010119-t1x9gknd 1963 7 0.89 0.89 CD cord-010119-t1x9gknd 1963 8 ) ) -RRB- cord-010119-t1x9gknd 1963 9 ] ] -RRB- cord-010119-t1x9gknd 1964 1 in in IN cord-010119-t1x9gknd 1964 2 addition addition NN cord-010119-t1x9gknd 1964 3 to to IN cord-010119-t1x9gknd 1964 4 a a DT cord-010119-t1x9gknd 1964 5 lower low JJR cord-010119-t1x9gknd 1964 6 risk risk NN cord-010119-t1x9gknd 1964 7 of of IN cord-010119-t1x9gknd 1964 8 causing cause VBG cord-010119-t1x9gknd 1964 9 citrate citrate NN cord-010119-t1x9gknd 1964 10 toxicity toxicity NN cord-010119-t1x9gknd 1964 11 [ [ -LRB- cord-010119-t1x9gknd 1964 12 p50.042 p50.042 NN cord-010119-t1x9gknd 1964 13 , , , cord-010119-t1x9gknd 1964 14 OR OR NNP cord-010119-t1x9gknd 1964 15 ( ( -LRB- cord-010119-t1x9gknd 1964 16 CI CI NNP cord-010119-t1x9gknd 1964 17 ) ) -RRB- cord-010119-t1x9gknd 1964 18 : : : cord-010119-t1x9gknd 1964 19 0 0 NFP cord-010119-t1x9gknd 1964 20 . . . cord-010119-t1x9gknd 1964 21 24 24 CD cord-010119-t1x9gknd 1964 22 ( ( -LRB- cord-010119-t1x9gknd 1964 23 0.06 0.06 CD cord-010119-t1x9gknd 1964 24 , , , cord-010119-t1x9gknd 1964 25 0.95 0.95 CD cord-010119-t1x9gknd 1964 26 ) ) -RRB- cord-010119-t1x9gknd 1964 27 ] ] -RRB- cord-010119-t1x9gknd 1964 28 . . . cord-010119-t1x9gknd 1965 1 Age age NN cord-010119-t1x9gknd 1965 2 had have VBD cord-010119-t1x9gknd 1965 3 a a DT cord-010119-t1x9gknd 1965 4 significant significant JJ cord-010119-t1x9gknd 1965 5 effect effect NN cord-010119-t1x9gknd 1965 6 on on IN cord-010119-t1x9gknd 1965 7 having have VBG cord-010119-t1x9gknd 1965 8 a a DT cord-010119-t1x9gknd 1965 9 hypotensive hypotensive JJ cord-010119-t1x9gknd 1965 10 event event NN cord-010119-t1x9gknd 1965 11 [ [ -LRB- cord-010119-t1x9gknd 1965 12 p50.04 p50.04 NN cord-010119-t1x9gknd 1965 13 , , , cord-010119-t1x9gknd 1965 14 OR or CC cord-010119-t1x9gknd 1965 15 ( ( -LRB- cord-010119-t1x9gknd 1965 16 CI):1.1 CI):1.1 NNP cord-010119-t1x9gknd 1965 17 ( ( -LRB- cord-010119-t1x9gknd 1965 18 1.0 1.0 CD cord-010119-t1x9gknd 1965 19 , , , cord-010119-t1x9gknd 1965 20 1.1 1.1 CD cord-010119-t1x9gknd 1965 21 ) ) -RRB- cord-010119-t1x9gknd 1965 22 ] ] -RRB- cord-010119-t1x9gknd 1966 1 but but CC cord-010119-t1x9gknd 1966 2 no no DT cord-010119-t1x9gknd 1966 3 effect effect NN cord-010119-t1x9gknd 1966 4 on on IN cord-010119-t1x9gknd 1966 5 citrate citrate NN cord-010119-t1x9gknd 1966 6 toxicity toxicity NN cord-010119-t1x9gknd 1966 7 or or CC cord-010119-t1x9gknd 1966 8 the the DT cord-010119-t1x9gknd 1966 9 combined combine VBN cord-010119-t1x9gknd 1966 10 outcome outcome NN cord-010119-t1x9gknd 1966 11 . . . cord-010119-t1x9gknd 1967 1 Gender gender NN cord-010119-t1x9gknd 1967 2 had have VBD cord-010119-t1x9gknd 1967 3 no no DT cord-010119-t1x9gknd 1967 4 effect effect NN cord-010119-t1x9gknd 1967 5 on on IN cord-010119-t1x9gknd 1967 6 frequency frequency NN cord-010119-t1x9gknd 1967 7 of of IN cord-010119-t1x9gknd 1967 8 any any DT cord-010119-t1x9gknd 1967 9 event event NN cord-010119-t1x9gknd 1967 10 . . . cord-010119-t1x9gknd 1968 1 Conclusion conclusion NN cord-010119-t1x9gknd 1968 2 : : : cord-010119-t1x9gknd 1968 3 Partial partial JJ cord-010119-t1x9gknd 1968 4 saline saline NN cord-010119-t1x9gknd 1968 5 use use NN cord-010119-t1x9gknd 1968 6 as as IN cord-010119-t1x9gknd 1968 7 a a DT cord-010119-t1x9gknd 1968 8 replacement replacement NN cord-010119-t1x9gknd 1968 9 fluid fluid NN cord-010119-t1x9gknd 1968 10 with with IN cord-010119-t1x9gknd 1968 11 albumin albumin NN cord-010119-t1x9gknd 1968 12 during during IN cord-010119-t1x9gknd 1968 13 plasma plasma NN cord-010119-t1x9gknd 1968 14 exchange exchange NN cord-010119-t1x9gknd 1968 15 significantly significantly RB cord-010119-t1x9gknd 1968 16 increases increase VBZ cord-010119-t1x9gknd 1968 17 the the DT cord-010119-t1x9gknd 1968 18 risk risk NN cord-010119-t1x9gknd 1968 19 of of IN cord-010119-t1x9gknd 1968 20 hypotension hypotension NN cord-010119-t1x9gknd 1968 21 and and CC cord-010119-t1x9gknd 1968 22 citrate citrate NN cord-010119-t1x9gknd 1968 23 toxicity toxicity NN cord-010119-t1x9gknd 1968 24 during during IN cord-010119-t1x9gknd 1968 25 the the DT cord-010119-t1x9gknd 1968 26 procedure procedure NN cord-010119-t1x9gknd 1968 27 . . . cord-010119-t1x9gknd 1969 1 Age age NN cord-010119-t1x9gknd 1969 2 also also RB cord-010119-t1x9gknd 1969 3 increases increase VBZ cord-010119-t1x9gknd 1969 4 the the DT cord-010119-t1x9gknd 1969 5 risk risk NN cord-010119-t1x9gknd 1969 6 of of IN cord-010119-t1x9gknd 1969 7 hypotension hypotension NN cord-010119-t1x9gknd 1969 8 . . . cord-010119-t1x9gknd 1970 1 Use use NN cord-010119-t1x9gknd 1970 2 of of IN cord-010119-t1x9gknd 1970 3 saline saline NN cord-010119-t1x9gknd 1970 4 as as IN cord-010119-t1x9gknd 1970 5 replacement replacement NN cord-010119-t1x9gknd 1970 6 fluid fluid NN cord-010119-t1x9gknd 1970 7 during during IN cord-010119-t1x9gknd 1970 8 plasma plasma NN cord-010119-t1x9gknd 1970 9 exchanges exchange NNS cord-010119-t1x9gknd 1970 10 should should MD cord-010119-t1x9gknd 1970 11 be be VB cord-010119-t1x9gknd 1970 12 minimized minimize VBN cord-010119-t1x9gknd 1970 13 to to TO cord-010119-t1x9gknd 1970 14 maximize maximize VB cord-010119-t1x9gknd 1970 15 patient patient JJ cord-010119-t1x9gknd 1970 16 safety safety NN cord-010119-t1x9gknd 1970 17 especially especially RB cord-010119-t1x9gknd 1970 18 in in IN cord-010119-t1x9gknd 1970 19 older old JJR cord-010119-t1x9gknd 1970 20 patients patient NNS cord-010119-t1x9gknd 1970 21 . . . cord-010119-t1x9gknd 1971 1 Background Background NNP cord-010119-t1x9gknd 1971 2 / / SYM cord-010119-t1x9gknd 1971 3 Case Case NNP cord-010119-t1x9gknd 1971 4 Studies Studies NNPS cord-010119-t1x9gknd 1971 5 : : : cord-010119-t1x9gknd 1971 6 Therapeutic therapeutic JJ cord-010119-t1x9gknd 1971 7 apheresis apheresis NN cord-010119-t1x9gknd 1971 8 ( ( -LRB- cord-010119-t1x9gknd 1971 9 TA TA NNP cord-010119-t1x9gknd 1971 10 ) ) -RRB- cord-010119-t1x9gknd 1971 11 is be VBZ cord-010119-t1x9gknd 1971 12 a a DT cord-010119-t1x9gknd 1971 13 complex complex JJ cord-010119-t1x9gknd 1971 14 procedure procedure NN cord-010119-t1x9gknd 1971 15 that that WDT cord-010119-t1x9gknd 1971 16 is be VBZ cord-010119-t1x9gknd 1971 17 mostly mostly RB cord-010119-t1x9gknd 1971 18 well well RB cord-010119-t1x9gknd 1971 19 - - HYPH cord-010119-t1x9gknd 1971 20 tolerated tolerate VBN cord-010119-t1x9gknd 1971 21 and and CC cord-010119-t1x9gknd 1971 22 rarely rarely RB cord-010119-t1x9gknd 1971 23 associated associate VBN cord-010119-t1x9gknd 1971 24 with with IN cord-010119-t1x9gknd 1971 25 adverse adverse JJ cord-010119-t1x9gknd 1971 26 events event NNS cord-010119-t1x9gknd 1971 27 ( ( -LRB- cord-010119-t1x9gknd 1971 28 AEs AEs NNP cord-010119-t1x9gknd 1971 29 ) ) -RRB- cord-010119-t1x9gknd 1971 30 . . . cord-010119-t1x9gknd 1972 1 There there EX cord-010119-t1x9gknd 1972 2 are be VBP cord-010119-t1x9gknd 1972 3 few few JJ cord-010119-t1x9gknd 1972 4 studies study NNS cord-010119-t1x9gknd 1972 5 published publish VBN cord-010119-t1x9gknd 1972 6 on on IN cord-010119-t1x9gknd 1972 7 AEs AEs NNP cord-010119-t1x9gknd 1972 8 associated associate VBN cord-010119-t1x9gknd 1972 9 with with IN cord-010119-t1x9gknd 1972 10 TA TA NNP cord-010119-t1x9gknd 1973 1 but but CC cord-010119-t1x9gknd 1973 2 they -PRON- PRP cord-010119-t1x9gknd 1973 3 lack lack VBP cord-010119-t1x9gknd 1973 4 uniformity uniformity NN cord-010119-t1x9gknd 1973 5 of of IN cord-010119-t1x9gknd 1973 6 data datum NNS cord-010119-t1x9gknd 1973 7 . . . cord-010119-t1x9gknd 1974 1 Moreover moreover RB cord-010119-t1x9gknd 1974 2 , , , cord-010119-t1x9gknd 1974 3 there there EX cord-010119-t1x9gknd 1974 4 is be VBZ cord-010119-t1x9gknd 1974 5 no no DT cord-010119-t1x9gknd 1974 6 common common JJ cord-010119-t1x9gknd 1974 7 database database NN cord-010119-t1x9gknd 1974 8 in in IN cord-010119-t1x9gknd 1974 9 the the DT cord-010119-t1x9gknd 1974 10 United United NNP cord-010119-t1x9gknd 1974 11 States States NNP cord-010119-t1x9gknd 1974 12 ( ( -LRB- cord-010119-t1x9gknd 1974 13 US US NNP cord-010119-t1x9gknd 1974 14 ) ) -RRB- cord-010119-t1x9gknd 1974 15 to to TO cord-010119-t1x9gknd 1974 16 report report VB cord-010119-t1x9gknd 1974 17 TA TA NNP cord-010119-t1x9gknd 1974 18 - - HYPH cord-010119-t1x9gknd 1974 19 associated associate VBN cord-010119-t1x9gknd 1974 20 AEs AEs NNP cord-010119-t1x9gknd 1974 21 . . . cord-010119-t1x9gknd 1975 1 We -PRON- PRP cord-010119-t1x9gknd 1975 2 evaluated evaluate VBD cord-010119-t1x9gknd 1975 3 the the DT cord-010119-t1x9gknd 1975 4 annual annual JJ cord-010119-t1x9gknd 1975 5 incidence incidence NN cord-010119-t1x9gknd 1975 6 rates rate NNS cord-010119-t1x9gknd 1975 7 of of IN cord-010119-t1x9gknd 1975 8 AEs ae NNS cord-010119-t1x9gknd 1975 9 associated associate VBN cord-010119-t1x9gknd 1975 10 with with IN cord-010119-t1x9gknd 1975 11 TA TA NNP cord-010119-t1x9gknd 1975 12 at at IN cord-010119-t1x9gknd 1975 13 a a DT cord-010119-t1x9gknd 1975 14 large large JJ cord-010119-t1x9gknd 1975 15 tertiary tertiary JJ cord-010119-t1x9gknd 1975 16 academic academic JJ cord-010119-t1x9gknd 1975 17 medical medical JJ cord-010119-t1x9gknd 1975 18 center center NN cord-010119-t1x9gknd 1975 19 over over IN cord-010119-t1x9gknd 1975 20 a a DT cord-010119-t1x9gknd 1975 21 10 10 CD cord-010119-t1x9gknd 1975 22 year year NN cord-010119-t1x9gknd 1975 23 period period NN cord-010119-t1x9gknd 1975 24 and and CC cord-010119-t1x9gknd 1975 25 compared compare VBD cord-010119-t1x9gknd 1975 26 it -PRON- PRP cord-010119-t1x9gknd 1975 27 to to IN cord-010119-t1x9gknd 1975 28 published publish VBN cord-010119-t1x9gknd 1975 29 literature literature NN cord-010119-t1x9gknd 1975 30 . . . cord-010119-t1x9gknd 1976 1 Study Study NNP cord-010119-t1x9gknd 1976 2 Design Design NNP cord-010119-t1x9gknd 1976 3 / / SYM cord-010119-t1x9gknd 1976 4 Method method NN cord-010119-t1x9gknd 1976 5 : : : cord-010119-t1x9gknd 1976 6 We -PRON- PRP cord-010119-t1x9gknd 1976 7 conducted conduct VBD cord-010119-t1x9gknd 1976 8 a a DT cord-010119-t1x9gknd 1976 9 10-year 10-year CD cord-010119-t1x9gknd 1976 10 retrospective retrospective JJ cord-010119-t1x9gknd 1976 11 study study NN cord-010119-t1x9gknd 1976 12 of of IN cord-010119-t1x9gknd 1976 13 TA TA NNP cord-010119-t1x9gknd 1976 14 procedures procedure NNS cord-010119-t1x9gknd 1976 15 performed perform VBN cord-010119-t1x9gknd 1976 16 and and CC cord-010119-t1x9gknd 1976 17 AEs AEs NNP cord-010119-t1x9gknd 1976 18 were be VBD cord-010119-t1x9gknd 1976 19 classified classify VBN cord-010119-t1x9gknd 1976 20 according accord VBG cord-010119-t1x9gknd 1976 21 to to IN cord-010119-t1x9gknd 1976 22 criteria criterion NNS cord-010119-t1x9gknd 1976 23 described describe VBN cord-010119-t1x9gknd 1976 24 in in IN cord-010119-t1x9gknd 1976 25 Table Table NNP cord-010119-t1x9gknd 1976 26 1 1 CD cord-010119-t1x9gknd 1976 27 . . . cord-010119-t1x9gknd 1977 1 During during IN cord-010119-t1x9gknd 1977 2 the the DT cord-010119-t1x9gknd 1977 3 study study NN cord-010119-t1x9gknd 1977 4 period period NN cord-010119-t1x9gknd 1977 5 , , , cord-010119-t1x9gknd 1977 6 TA TA NNP cord-010119-t1x9gknd 1977 7 were be VBD cord-010119-t1x9gknd 1977 8 performed perform VBN cord-010119-t1x9gknd 1977 9 using use VBG cord-010119-t1x9gknd 1977 10 COBE COBE NNP cord-010119-t1x9gknd 1977 11 Spectra Spectra NNP cord-010119-t1x9gknd 1977 12 ( ( -LRB- cord-010119-t1x9gknd 1977 13 Software Software NNP cord-010119-t1x9gknd 1977 14 versions version NNS cord-010119-t1x9gknd 1977 15 4.7 4.7 CD cord-010119-t1x9gknd 1977 16 and and CC cord-010119-t1x9gknd 1977 17 6.1 6.1 CD cord-010119-t1x9gknd 1977 18 ) ) -RRB- cord-010119-t1x9gknd 1977 19 and and CC cord-010119-t1x9gknd 1977 20 since since IN cord-010119-t1x9gknd 1977 21 2013 2013 CD cord-010119-t1x9gknd 1977 22 the the DT cord-010119-t1x9gknd 1977 23 Spectra Spectra NNP cord-010119-t1x9gknd 1977 24 Optia Optia NNP cord-010119-t1x9gknd 1977 25 apheresis apheresis NN cord-010119-t1x9gknd 1977 26 system system NN cord-010119-t1x9gknd 1977 27 ( ( -LRB- cord-010119-t1x9gknd 1977 28 version version NN cord-010119-t1x9gknd 1977 29 8.0 8.0 CD cord-010119-t1x9gknd 1977 30 ) ) -RRB- cord-010119-t1x9gknd 1977 31 . . . cord-010119-t1x9gknd 1978 1 Literature literature NN cord-010119-t1x9gknd 1978 2 search search NN cord-010119-t1x9gknd 1978 3 was be VBD cord-010119-t1x9gknd 1978 4 conducted conduct VBN cord-010119-t1x9gknd 1978 5 for for IN cord-010119-t1x9gknd 1978 6 data datum NNS cord-010119-t1x9gknd 1978 7 published publish VBN cord-010119-t1x9gknd 1978 8 on on IN cord-010119-t1x9gknd 1978 9 AEs AEs NNP cord-010119-t1x9gknd 1978 10 associated associate VBN cord-010119-t1x9gknd 1978 11 with with IN cord-010119-t1x9gknd 1978 12 TA TA NNP cord-010119-t1x9gknd 1978 13 . . . cord-010119-t1x9gknd 1979 1 Four four CD cord-010119-t1x9gknd 1979 2 studies study NNS cord-010119-t1x9gknd 1979 3 from from IN cord-010119-t1x9gknd 1979 4 US US NNP cord-010119-t1x9gknd 1979 5 and and CC cord-010119-t1x9gknd 1979 6 13 13 CD cord-010119-t1x9gknd 1979 7 non non JJ cord-010119-t1x9gknd 1979 8 - - JJ cord-010119-t1x9gknd 1979 9 US US NNP cord-010119-t1x9gknd 1979 10 studies study NNS cord-010119-t1x9gknd 1979 11 ( ( -LRB- cord-010119-t1x9gknd 1979 12 Canada Canada NNP cord-010119-t1x9gknd 1979 13 , , , cord-010119-t1x9gknd 1979 14 Europe Europe NNP cord-010119-t1x9gknd 1979 15 and and CC cord-010119-t1x9gknd 1979 16 Japan Japan NNP cord-010119-t1x9gknd 1979 17 ) ) -RRB- cord-010119-t1x9gknd 1979 18 were be VBD cord-010119-t1x9gknd 1979 19 analyzed analyze VBN cord-010119-t1x9gknd 1979 20 . . . cord-010119-t1x9gknd 1980 1 Trend trend NN cord-010119-t1x9gknd 1980 2 for for IN cord-010119-t1x9gknd 1980 3 AE ae NN cord-010119-t1x9gknd 1980 4 rates rate NNS cord-010119-t1x9gknd 1980 5 from from IN cord-010119-t1x9gknd 1980 6 2007 2007 CD cord-010119-t1x9gknd 1980 7 - - SYM cord-010119-t1x9gknd 1980 8 16 16 CD cord-010119-t1x9gknd 1980 9 was be VBD cord-010119-t1x9gknd 1980 10 also also RB cord-010119-t1x9gknd 1980 11 analyzed analyze VBN cord-010119-t1x9gknd 1980 12 . . . cord-010119-t1x9gknd 1981 1 Statistical statistical JJ cord-010119-t1x9gknd 1981 2 analysis analysis NN cord-010119-t1x9gknd 1981 3 was be VBD cord-010119-t1x9gknd 1981 4 performed perform VBN cord-010119-t1x9gknd 1981 5 using use VBG cord-010119-t1x9gknd 1981 6 Chi Chi NNP cord-010119-t1x9gknd 1981 7 square square NNP cord-010119-t1x9gknd 1981 8 and and CC cord-010119-t1x9gknd 1981 9 Spearman Spearman NNP cord-010119-t1x9gknd 1981 10 rho rho NN cord-010119-t1x9gknd 1981 11 tests test VBZ cord-010119-t1x9gknd 1981 12 . . . cord-010119-t1x9gknd 1982 1 Results result NNS cord-010119-t1x9gknd 1982 2 / / SYM cord-010119-t1x9gknd 1982 3 Finding finding NN cord-010119-t1x9gknd 1982 4 : : : cord-010119-t1x9gknd 1982 5 The the DT cord-010119-t1x9gknd 1982 6 overall overall JJ cord-010119-t1x9gknd 1982 7 AE AE NNP cord-010119-t1x9gknd 1982 8 incidence incidence NN cord-010119-t1x9gknd 1982 9 was be VBD cord-010119-t1x9gknd 1982 10 6.9 6.9 CD cord-010119-t1x9gknd 1982 11 % % NN cord-010119-t1x9gknd 1982 12 ( ( -LRB- cord-010119-t1x9gknd 1982 13 396 396 CD cord-010119-t1x9gknd 1982 14 of of IN cord-010119-t1x9gknd 1982 15 5,684 5,684 CD cord-010119-t1x9gknd 1982 16 procedures procedure NNS cord-010119-t1x9gknd 1982 17 ) ) -RRB- cord-010119-t1x9gknd 1982 18 during during IN cord-010119-t1x9gknd 1982 19 10 10 CD cord-010119-t1x9gknd 1982 20 year year NN cord-010119-t1x9gknd 1982 21 period period NN cord-010119-t1x9gknd 1982 22 . . . cord-010119-t1x9gknd 1983 1 Frequency Frequency NNP cord-010119-t1x9gknd 1983 2 of of IN cord-010119-t1x9gknd 1983 3 AEs ae NNS cord-010119-t1x9gknd 1983 4 associated associate VBN cord-010119-t1x9gknd 1983 5 with with IN cord-010119-t1x9gknd 1983 6 therapeutic therapeutic JJ cord-010119-t1x9gknd 1983 7 plasma plasma NN cord-010119-t1x9gknd 1983 8 exchange exchange NN cord-010119-t1x9gknd 1983 9 ( ( -LRB- cord-010119-t1x9gknd 1983 10 TPE TPE NNP cord-010119-t1x9gknd 1983 11 ) ) -RRB- cord-010119-t1x9gknd 1983 12 was be VBD cord-010119-t1x9gknd 1983 13 significantly significantly RB cord-010119-t1x9gknd 1983 14 higher high JJR cord-010119-t1x9gknd 1983 15 ( ( -LRB- cord-010119-t1x9gknd 1983 16 8.5 8.5 CD cord-010119-t1x9gknd 1983 17 % % NN cord-010119-t1x9gknd 1983 18 , , , cord-010119-t1x9gknd 1983 19 p<0.00001 p<0.00001 NNP cord-010119-t1x9gknd 1983 20 ) ) -RRB- cord-010119-t1x9gknd 1983 21 compared compare VBN cord-010119-t1x9gknd 1983 22 to to IN cord-010119-t1x9gknd 1983 23 other other JJ cord-010119-t1x9gknd 1983 24 TA TA NNP cord-010119-t1x9gknd 1983 25 procedures procedure NNS cord-010119-t1x9gknd 1983 26 . . . cord-010119-t1x9gknd 1984 1 We -PRON- PRP cord-010119-t1x9gknd 1984 2 found find VBD cord-010119-t1x9gknd 1984 3 significant significant JJ cord-010119-t1x9gknd 1984 4 correlation correlation NN cord-010119-t1x9gknd 1984 5 between between IN cord-010119-t1x9gknd 1984 6 number number NN cord-010119-t1x9gknd 1984 7 of of IN cord-010119-t1x9gknd 1984 8 TPE TPE NNP cord-010119-t1x9gknd 1984 9 and and CC cord-010119-t1x9gknd 1984 10 AEs AEs NNP cord-010119-t1x9gknd 1985 1 ( ( -LRB- cord-010119-t1x9gknd 1985 2 Spearman Spearman NNP cord-010119-t1x9gknd 1985 3 rho rho NNP cord-010119-t1x9gknd 1985 4 0.7 0.7 CD cord-010119-t1x9gknd 1985 5 , , , cord-010119-t1x9gknd 1985 6 p50.002 p50.002 NNP cord-010119-t1x9gknd 1985 7 ) ) -RRB- cord-010119-t1x9gknd 1985 8 over over IN cord-010119-t1x9gknd 1985 9 the the DT cord-010119-t1x9gknd 1985 10 10 10 CD cord-010119-t1x9gknd 1985 11 years year NNS cord-010119-t1x9gknd 1985 12 and and CC cord-010119-t1x9gknd 1985 13 significant significant JJ cord-010119-t1x9gknd 1985 14 down down JJ cord-010119-t1x9gknd 1985 15 trend trend NN cord-010119-t1x9gknd 1985 16 of of IN cord-010119-t1x9gknd 1985 17 moderate moderate JJ cord-010119-t1x9gknd 1985 18 and and CC cord-010119-t1x9gknd 1985 19 severe severe JJ cord-010119-t1x9gknd 1985 20 AEs ae NNS cord-010119-t1x9gknd 1985 21 with with IN cord-010119-t1x9gknd 1985 22 a a DT cord-010119-t1x9gknd 1985 23 Spearman Spearman NNP cord-010119-t1x9gknd 1985 24 rho rho NN cord-010119-t1x9gknd 1985 25 of of IN cord-010119-t1x9gknd 1985 26 -0.64 -0.64 : cord-010119-t1x9gknd 1985 27 ( ( -LRB- cord-010119-t1x9gknd 1985 28 p50.04 p50.04 NN cord-010119-t1x9gknd 1985 29 ) ) -RRB- cord-010119-t1x9gknd 1985 30 and and CC cord-010119-t1x9gknd 1985 31 -0.83 -0.83 . cord-010119-t1x9gknd 1985 32 ( ( -LRB- cord-010119-t1x9gknd 1985 33 p50.003 p50.003 NN cord-010119-t1x9gknd 1985 34 ) ) -RRB- cord-010119-t1x9gknd 1985 35 respectively respectively RB cord-010119-t1x9gknd 1985 36 . . . cord-010119-t1x9gknd 1986 1 There there EX cord-010119-t1x9gknd 1986 2 were be VBD cord-010119-t1x9gknd 1986 3 no no DT cord-010119-t1x9gknd 1986 4 fatalities fatality NNS cord-010119-t1x9gknd 1986 5 during during IN cord-010119-t1x9gknd 1986 6 the the DT cord-010119-t1x9gknd 1986 7 study study NN cord-010119-t1x9gknd 1986 8 period period NN cord-010119-t1x9gknd 1986 9 . . . cord-010119-t1x9gknd 1987 1 Majority majority NN cord-010119-t1x9gknd 1987 2 of of IN cord-010119-t1x9gknd 1987 3 AEs AEs NNP cord-010119-t1x9gknd 1987 4 were be VBD cord-010119-t1x9gknd 1988 1 Grade grade NN cord-010119-t1x9gknd 1988 2 I -PRON- PRP cord-010119-t1x9gknd 1988 3 ( ( -LRB- cord-010119-t1x9gknd 1988 4 60 60 CD cord-010119-t1x9gknd 1988 5 % % NN cord-010119-t1x9gknd 1988 6 ) ) -RRB- cord-010119-t1x9gknd 1988 7 and and CC cord-010119-t1x9gknd 1988 8 Grade Grade NNP cord-010119-t1x9gknd 1988 9 II II NNP cord-010119-t1x9gknd 1988 10 ( ( -LRB- cord-010119-t1x9gknd 1988 11 28 28 CD cord-010119-t1x9gknd 1988 12 % % NN cord-010119-t1x9gknd 1988 13 ) ) -RRB- cord-010119-t1x9gknd 1988 14 : : : cord-010119-t1x9gknd 1988 15 32/5684 32/5684 LS cord-010119-t1x9gknd 1988 16 ( ( -LRB- cord-010119-t1x9gknd 1988 17 0.6 0.6 CD cord-010119-t1x9gknd 1988 18 % % NN cord-010119-t1x9gknd 1988 19 ) ) -RRB- cord-010119-t1x9gknd 1988 20 procedures procedure NNS cord-010119-t1x9gknd 1988 21 were be VBD cord-010119-t1x9gknd 1988 22 not not RB cord-010119-t1x9gknd 1988 23 completed complete VBN cord-010119-t1x9gknd 1988 24 due due IN cord-010119-t1x9gknd 1988 25 to to IN cord-010119-t1x9gknd 1988 26 AEs AEs NNP cord-010119-t1x9gknd 1988 27 . . . cord-010119-t1x9gknd 1989 1 Comparison comparison NN cord-010119-t1x9gknd 1989 2 of of IN cord-010119-t1x9gknd 1989 3 AEs AEs NNPS cord-010119-t1x9gknd 1989 4 [ [ -LRB- cord-010119-t1x9gknd 1989 5 6.9 6.9 CD cord-010119-t1x9gknd 1989 6 % % NN cord-010119-t1x9gknd 1989 7 ( ( -LRB- cord-010119-t1x9gknd 1989 8 396/5,684 396/5,684 NN cord-010119-t1x9gknd 1989 9 ) ) -RRB- cord-010119-t1x9gknd 1989 10 ] ] -RRB- cord-010119-t1x9gknd 1989 11 to to IN cord-010119-t1x9gknd 1989 12 both both CC cord-010119-t1x9gknd 1989 13 European european JJ cord-010119-t1x9gknd 1989 14 [ [ -LRB- cord-010119-t1x9gknd 1989 15 11.2 11.2 CD cord-010119-t1x9gknd 1989 16 % % NN cord-010119-t1x9gknd 1989 17 ( ( -LRB- cord-010119-t1x9gknd 1989 18 N513 n513 CD cord-010119-t1x9gknd 1989 19 , , , cord-010119-t1x9gknd 1989 20 12 12 CD cord-010119-t1x9gknd 1989 21 , , , cord-010119-t1x9gknd 1989 22 256/ 256/ CD cord-010119-t1x9gknd 1989 23 109 109 CD cord-010119-t1x9gknd 1989 24 , , , cord-010119-t1x9gknd 1989 25 842 842 CD cord-010119-t1x9gknd 1989 26 ) ) -RRB- cord-010119-t1x9gknd 1989 27 ] ] -RRB- cord-010119-t1x9gknd 1989 28 and and CC cord-010119-t1x9gknd 1989 29 other other JJ cord-010119-t1x9gknd 1989 30 US US NNP cord-010119-t1x9gknd 1989 31 studies study NNS cord-010119-t1x9gknd 1989 32 [ [ -LRB- cord-010119-t1x9gknd 1989 33 13.6 13.6 CD cord-010119-t1x9gknd 1989 34 % % NN cord-010119-t1x9gknd 1989 35 ( ( -LRB- cord-010119-t1x9gknd 1989 36 N54 N54 NNP cord-010119-t1x9gknd 1989 37 , , , cord-010119-t1x9gknd 1989 38 860/6,324 860/6,324 CD cord-010119-t1x9gknd 1989 39 ) ) -RRB- cord-010119-t1x9gknd 1989 40 ] ] -RRB- cord-010119-t1x9gknd 1989 41 showed show VBD cord-010119-t1x9gknd 1989 42 a a DT cord-010119-t1x9gknd 1989 43 statistically statistically RB cord-010119-t1x9gknd 1989 44 significant significant JJ cord-010119-t1x9gknd 1989 45 difference difference NN cord-010119-t1x9gknd 1989 46 ( ( -LRB- cord-010119-t1x9gknd 1989 47 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 1989 48 ) ) -RRB- cord-010119-t1x9gknd 1989 49 . . . cord-010119-t1x9gknd 1990 1 Conclusion conclusion NN cord-010119-t1x9gknd 1990 2 : : : cord-010119-t1x9gknd 1991 1 Overall overall JJ cord-010119-t1x9gknd 1991 2 incidence incidence NN cord-010119-t1x9gknd 1991 3 of of IN cord-010119-t1x9gknd 1991 4 AEs AEs NNP cord-010119-t1x9gknd 1991 5 was be VBD cord-010119-t1x9gknd 1991 6 significantly significantly RB cord-010119-t1x9gknd 1991 7 lower low JJR cord-010119-t1x9gknd 1991 8 than than IN cord-010119-t1x9gknd 1991 9 current current JJ cord-010119-t1x9gknd 1991 10 published publish VBN cord-010119-t1x9gknd 1991 11 literature literature NN cord-010119-t1x9gknd 1991 12 . . . cord-010119-t1x9gknd 1992 1 Incidence incidence NN cord-010119-t1x9gknd 1992 2 of of IN cord-010119-t1x9gknd 1992 3 AEs AEs NNP cord-010119-t1x9gknd 1992 4 published publish VBN cord-010119-t1x9gknd 1992 5 in in IN cord-010119-t1x9gknd 1992 6 other other JJ cord-010119-t1x9gknd 1992 7 countries country NNS cord-010119-t1x9gknd 1992 8 is be VBZ cord-010119-t1x9gknd 1992 9 significantly significantly RB cord-010119-t1x9gknd 1992 10 lower low JJR cord-010119-t1x9gknd 1992 11 than than IN cord-010119-t1x9gknd 1992 12 rates rate NNS cord-010119-t1x9gknd 1992 13 published publish VBN cord-010119-t1x9gknd 1992 14 in in IN cord-010119-t1x9gknd 1992 15 US US NNP cord-010119-t1x9gknd 1992 16 . . . cord-010119-t1x9gknd 1993 1 Differences difference NNS cord-010119-t1x9gknd 1993 2 in in IN cord-010119-t1x9gknd 1993 3 incidence incidence NN cord-010119-t1x9gknd 1993 4 of of IN cord-010119-t1x9gknd 1993 5 AEs AEs NNP cord-010119-t1x9gknd 1993 6 in in IN cord-010119-t1x9gknd 1993 7 literature literature NN cord-010119-t1x9gknd 1993 8 emphasizes emphasize VBZ cord-010119-t1x9gknd 1993 9 need need NN cord-010119-t1x9gknd 1993 10 for for IN cord-010119-t1x9gknd 1993 11 uniform uniform JJ cord-010119-t1x9gknd 1993 12 reporting reporting NN cord-010119-t1x9gknd 1993 13 and and CC cord-010119-t1x9gknd 1993 14 stratification stratification NN cord-010119-t1x9gknd 1993 15 of of IN cord-010119-t1x9gknd 1993 16 AEs ae NNS cord-010119-t1x9gknd 1993 17 and and CC cord-010119-t1x9gknd 1993 18 development development NN cord-010119-t1x9gknd 1993 19 of of IN cord-010119-t1x9gknd 1993 20 a a DT cord-010119-t1x9gknd 1993 21 common common JJ cord-010119-t1x9gknd 1993 22 database database NN cord-010119-t1x9gknd 1993 23 to to TO cord-010119-t1x9gknd 1993 24 report report VB cord-010119-t1x9gknd 1993 25 TA TA NNP cord-010119-t1x9gknd 1993 26 - - HYPH cord-010119-t1x9gknd 1993 27 associated associate VBN cord-010119-t1x9gknd 1993 28 AEs AEs NNP cord-010119-t1x9gknd 1993 29 . . . cord-010119-t1x9gknd 1994 1 We -PRON- PRP cord-010119-t1x9gknd 1994 2 propose propose VBP cord-010119-t1x9gknd 1994 3 a a DT cord-010119-t1x9gknd 1994 4 grading grading NN cord-010119-t1x9gknd 1994 5 rationale rationale NN cord-010119-t1x9gknd 1994 6 in in IN cord-010119-t1x9gknd 1994 7 order order NN cord-010119-t1x9gknd 1994 8 to to TO cord-010119-t1x9gknd 1994 9 standardize standardize VB cord-010119-t1x9gknd 1994 10 reporting report VBG cord-010119-t1x9gknd 1994 11 of of IN cord-010119-t1x9gknd 1994 12 AE AE NNP cord-010119-t1x9gknd 1994 13 ( ( -LRB- cord-010119-t1x9gknd 1994 14 Table table NN cord-010119-t1x9gknd 1994 15 1 1 CD cord-010119-t1x9gknd 1994 16 ) ) -RRB- cord-010119-t1x9gknd 1994 17 . . . cord-010119-t1x9gknd 1995 1 Variations variation NNS cord-010119-t1x9gknd 1995 2 in in IN cord-010119-t1x9gknd 1995 3 Biochemical Biochemical NNP cord-010119-t1x9gknd 1995 4 Markers Markers NNPS cord-010119-t1x9gknd 1995 5 of of IN cord-010119-t1x9gknd 1995 6 Bone Bone NNP cord-010119-t1x9gknd 1995 7 Metabolism Metabolism NNP cord-010119-t1x9gknd 1995 8 during during IN cord-010119-t1x9gknd 1995 9 Plateletpheresis Plateletpheresis NNP cord-010119-t1x9gknd 1995 10 : : : cord-010119-t1x9gknd 1995 11 Impact Impact NNP cord-010119-t1x9gknd 1995 12 of of IN cord-010119-t1x9gknd 1995 13 Socio Socio NNP cord-010119-t1x9gknd 1995 14 - - HYPH cord-010119-t1x9gknd 1995 15 Demographic demographic JJ cord-010119-t1x9gknd 1995 16 and and CC cord-010119-t1x9gknd 1995 17 Lifestyle Lifestyle NNP cord-010119-t1x9gknd 1995 18 Factors factor NNS cord-010119-t1x9gknd 1995 19 ? ? . cord-010119-t1x9gknd 1996 1 Markus Markus NNP cord-010119-t1x9gknd 1996 2 Dettke Dettke NNP cord-010119-t1x9gknd 1997 1 * * NFP cord-010119-t1x9gknd 1997 2 . . . cord-010119-t1x9gknd 1998 1 AKH AKH NNP cord-010119-t1x9gknd 1998 2 Vienna Vienna NNP cord-010119-t1x9gknd 1998 3 University University NNP cord-010119-t1x9gknd 1998 4 Hospital Hospital NNP cord-010119-t1x9gknd 1998 5 Background Background NNP cord-010119-t1x9gknd 1998 6 / / SYM cord-010119-t1x9gknd 1998 7 Case Case NNP cord-010119-t1x9gknd 1998 8 Studies Studies NNPS cord-010119-t1x9gknd 1999 1 : : : cord-010119-t1x9gknd 1999 2 Plateletpheresis Plateletpheresis NNP cord-010119-t1x9gknd 1999 3 is be VBZ cord-010119-t1x9gknd 1999 4 associated associate VBN cord-010119-t1x9gknd 1999 5 with with IN cord-010119-t1x9gknd 1999 6 short short JJ cord-010119-t1x9gknd 1999 7 - - HYPH cord-010119-t1x9gknd 1999 8 term term NN cord-010119-t1x9gknd 1999 9 variations variation NNS cord-010119-t1x9gknd 1999 10 in in IN cord-010119-t1x9gknd 1999 11 biochemical biochemical JJ cord-010119-t1x9gknd 1999 12 markers marker NNS cord-010119-t1x9gknd 1999 13 of of IN cord-010119-t1x9gknd 1999 14 bone bone NN cord-010119-t1x9gknd 1999 15 turnover turnover NN cord-010119-t1x9gknd 1999 16 . . . cord-010119-t1x9gknd 2000 1 Socio socio JJ cord-010119-t1x9gknd 2000 2 - - HYPH cord-010119-t1x9gknd 2000 3 demographic demographic JJ cord-010119-t1x9gknd 2000 4 factors factor NNS cord-010119-t1x9gknd 2000 5 and and CC cord-010119-t1x9gknd 2000 6 lifestyle lifestyle NN cord-010119-t1x9gknd 2000 7 behaviors behavior NNS cord-010119-t1x9gknd 2000 8 are be VBP cord-010119-t1x9gknd 2000 9 recognized recognize VBN cord-010119-t1x9gknd 2000 10 factors factor NNS cord-010119-t1x9gknd 2000 11 which which WDT cord-010119-t1x9gknd 2000 12 influence influence VBP cord-010119-t1x9gknd 2000 13 mineral mineral NN cord-010119-t1x9gknd 2000 14 metabolism metabolism NN cord-010119-t1x9gknd 2000 15 and and CC cord-010119-t1x9gknd 2000 16 bone bone NN cord-010119-t1x9gknd 2000 17 health health NN cord-010119-t1x9gknd 2000 18 . . . cord-010119-t1x9gknd 2001 1 In in IN cord-010119-t1x9gknd 2001 2 the the DT cord-010119-t1x9gknd 2001 3 present present JJ cord-010119-t1x9gknd 2001 4 study study NN cord-010119-t1x9gknd 2001 5 we -PRON- PRP cord-010119-t1x9gknd 2001 6 analyzed analyze VBD cord-010119-t1x9gknd 2001 7 the the DT cord-010119-t1x9gknd 2001 8 influence influence NN cord-010119-t1x9gknd 2001 9 of of IN cord-010119-t1x9gknd 2001 10 demographic demographic JJ cord-010119-t1x9gknd 2001 11 and and CC cord-010119-t1x9gknd 2001 12 lifestyle lifestyle NN cord-010119-t1x9gknd 2001 13 factors factor NNS cord-010119-t1x9gknd 2001 14 on on IN cord-010119-t1x9gknd 2001 15 the the DT cord-010119-t1x9gknd 2001 16 observed observed JJ cord-010119-t1x9gknd 2001 17 changes change NNS cord-010119-t1x9gknd 2001 18 in in IN cord-010119-t1x9gknd 2001 19 bone bone NN cord-010119-t1x9gknd 2001 20 markers marker NNS cord-010119-t1x9gknd 2001 21 in in IN cord-010119-t1x9gknd 2001 22 a a DT cord-010119-t1x9gknd 2001 23 large large JJ cord-010119-t1x9gknd 2001 24 cohort cohort NN cord-010119-t1x9gknd 2001 25 of of IN cord-010119-t1x9gknd 2001 26 routine routine JJ cord-010119-t1x9gknd 2001 27 platelet platelet NN cord-010119-t1x9gknd 2001 28 donors donor NNS cord-010119-t1x9gknd 2001 29 . . . cord-010119-t1x9gknd 2002 1 Study Study NNP cord-010119-t1x9gknd 2002 2 Design Design NNP cord-010119-t1x9gknd 2002 3 / / SYM cord-010119-t1x9gknd 2002 4 Method method NN cord-010119-t1x9gknd 2002 5 : : : cord-010119-t1x9gknd 2002 6 Altogether altogether RB cord-010119-t1x9gknd 2002 7 200 200 CD cord-010119-t1x9gknd 2002 8 platelet platelet NN cord-010119-t1x9gknd 2002 9 donors donor NNS cord-010119-t1x9gknd 2002 10 with with IN cord-010119-t1x9gknd 2002 11 a a DT cord-010119-t1x9gknd 2002 12 donation donation NN cord-010119-t1x9gknd 2002 13 activity activity NN cord-010119-t1x9gknd 2002 14 of of IN cord-010119-t1x9gknd 2002 15 up up IN cord-010119-t1x9gknd 2002 16 to to TO cord-010119-t1x9gknd 2002 17 150 150 CD cord-010119-t1x9gknd 2002 18 platelet platelet NN cord-010119-t1x9gknd 2002 19 donations donation NNS cord-010119-t1x9gknd 2002 20 participated participate VBD cord-010119-t1x9gknd 2002 21 in in IN cord-010119-t1x9gknd 2002 22 the the DT cord-010119-t1x9gknd 2002 23 study study NN cord-010119-t1x9gknd 2002 24 . . . cord-010119-t1x9gknd 2003 1 After after IN cord-010119-t1x9gknd 2003 2 a a DT cord-010119-t1x9gknd 2003 3 detailed detailed JJ cord-010119-t1x9gknd 2003 4 anamnesis anamnesis NN cord-010119-t1x9gknd 2003 5 all all DT cord-010119-t1x9gknd 2003 6 participants participant NNS cord-010119-t1x9gknd 2003 7 underwent undergo VBD cord-010119-t1x9gknd 2003 8 a a DT cord-010119-t1x9gknd 2003 9 standardized standardized JJ cord-010119-t1x9gknd 2003 10 questioner questioner NN cord-010119-t1x9gknd 2003 11 asking ask VBG cord-010119-t1x9gknd 2003 12 for for IN cord-010119-t1x9gknd 2003 13 several several JJ cord-010119-t1x9gknd 2003 14 lifestyle lifestyle NN cord-010119-t1x9gknd 2003 15 factors factor NNS cord-010119-t1x9gknd 2003 16 known know VBN cord-010119-t1x9gknd 2003 17 to to TO cord-010119-t1x9gknd 2003 18 affect affect VB cord-010119-t1x9gknd 2003 19 bone bone NN cord-010119-t1x9gknd 2003 20 metabolism metabolism NN cord-010119-t1x9gknd 2003 21 . . . cord-010119-t1x9gknd 2004 1 Blood blood NN cord-010119-t1x9gknd 2004 2 was be VBD cord-010119-t1x9gknd 2004 3 sampled sample VBN cord-010119-t1x9gknd 2004 4 before before IN cord-010119-t1x9gknd 2004 5 and and CC cord-010119-t1x9gknd 2004 6 after after IN cord-010119-t1x9gknd 2004 7 plateletpheresis plateletpheresis NNP cord-010119-t1x9gknd 2004 8 and and CC cord-010119-t1x9gknd 2004 9 was be VBD cord-010119-t1x9gknd 2004 10 analyzed analyze VBN cord-010119-t1x9gknd 2004 11 for for IN cord-010119-t1x9gknd 2004 12 the the DT cord-010119-t1x9gknd 2004 13 bone bone NN cord-010119-t1x9gknd 2004 14 formation formation NN cord-010119-t1x9gknd 2004 15 marker marker NN cord-010119-t1x9gknd 2004 16 osteocalcin osteocalcin NN cord-010119-t1x9gknd 2004 17 ( ( -LRB- cord-010119-t1x9gknd 2004 18 OC OC NNP cord-010119-t1x9gknd 2004 19 ) ) -RRB- cord-010119-t1x9gknd 2004 20 and and CC cord-010119-t1x9gknd 2004 21 the the DT cord-010119-t1x9gknd 2004 22 bone bone NN cord-010119-t1x9gknd 2004 23 resorption resorption NN cord-010119-t1x9gknd 2004 24 marker marker NN cord-010119-t1x9gknd 2004 25 cross cross RB cord-010119-t1x9gknd 2004 26 - - JJ cord-010119-t1x9gknd 2004 27 linked link VBN cord-010119-t1x9gknd 2004 28 telopeptides telopeptide NNS cord-010119-t1x9gknd 2004 29 of of IN cord-010119-t1x9gknd 2004 30 type type NN cord-010119-t1x9gknd 2004 31 I -PRON- PRP cord-010119-t1x9gknd 2004 32 collagen collagen NN cord-010119-t1x9gknd 2004 33 ( ( -LRB- cord-010119-t1x9gknd 2004 34 CTX CTX NNP cord-010119-t1x9gknd 2004 35 ) ) -RRB- cord-010119-t1x9gknd 2004 36 , , , cord-010119-t1x9gknd 2004 37 among among IN cord-010119-t1x9gknd 2004 38 other other JJ cord-010119-t1x9gknd 2004 39 parameters parameter NNS cord-010119-t1x9gknd 2004 40 . . . cord-010119-t1x9gknd 2005 1 The the DT cord-010119-t1x9gknd 2005 2 effect effect NN cord-010119-t1x9gknd 2005 3 of of IN cord-010119-t1x9gknd 2005 4 calcium calcium NN cord-010119-t1x9gknd 2005 5 supplementation supplementation NN cord-010119-t1x9gknd 2005 6 on on IN cord-010119-t1x9gknd 2005 7 bone bone NN cord-010119-t1x9gknd 2005 8 metabolism metabolism NN cord-010119-t1x9gknd 2005 9 was be VBD cord-010119-t1x9gknd 2005 10 tested test VBN cord-010119-t1x9gknd 2005 11 in in IN cord-010119-t1x9gknd 2005 12 a a DT cord-010119-t1x9gknd 2005 13 placebocontrolled placebocontrolled JJ cord-010119-t1x9gknd 2005 14 crossover crossover NN cord-010119-t1x9gknd 2005 15 study study NN cord-010119-t1x9gknd 2005 16 involving involve VBG cord-010119-t1x9gknd 2005 17 ten ten CD cord-010119-t1x9gknd 2005 18 donors donor NNS cord-010119-t1x9gknd 2005 19 . . . cord-010119-t1x9gknd 2006 1 Results/ Results/ . cord-010119-t1x9gknd 2007 1 Finding finding NN cord-010119-t1x9gknd 2007 2 : : : cord-010119-t1x9gknd 2007 3 Plateletpheresis Plateletpheresis NNP cord-010119-t1x9gknd 2007 4 resulted result VBD cord-010119-t1x9gknd 2007 5 in in IN cord-010119-t1x9gknd 2007 6 an an DT cord-010119-t1x9gknd 2007 7 increase increase NN cord-010119-t1x9gknd 2007 8 in in IN cord-010119-t1x9gknd 2007 9 the the DT cord-010119-t1x9gknd 2007 10 serum serum NN cord-010119-t1x9gknd 2007 11 levels level NNS cord-010119-t1x9gknd 2007 12 of of IN cord-010119-t1x9gknd 2007 13 the the DT cord-010119-t1x9gknd 2007 14 bone bone NN cord-010119-t1x9gknd 2007 15 resorption resorption NN cord-010119-t1x9gknd 2007 16 marker marker NN cord-010119-t1x9gknd 2007 17 CTX CTX NNP cord-010119-t1x9gknd 2007 18 and and CC cord-010119-t1x9gknd 2007 19 the the DT cord-010119-t1x9gknd 2007 20 bone bone NN cord-010119-t1x9gknd 2007 21 formation formation NN cord-010119-t1x9gknd 2007 22 marker marker NN cord-010119-t1x9gknd 2007 23 OC OC NNP cord-010119-t1x9gknd 2007 24 . . . cord-010119-t1x9gknd 2008 1 Both both DT cord-010119-t1x9gknd 2008 2 parameters parameter NNS cord-010119-t1x9gknd 2008 3 returned return VBD cord-010119-t1x9gknd 2008 4 to to IN cord-010119-t1x9gknd 2008 5 base base NN cord-010119-t1x9gknd 2008 6 levels level NNS cord-010119-t1x9gknd 2008 7 within within IN cord-010119-t1x9gknd 2008 8 2 2 CD cord-010119-t1x9gknd 2008 9 hours hour NNS cord-010119-t1x9gknd 2008 10 after after IN cord-010119-t1x9gknd 2008 11 the the DT cord-010119-t1x9gknd 2008 12 end end NN cord-010119-t1x9gknd 2008 13 of of IN cord-010119-t1x9gknd 2008 14 the the DT cord-010119-t1x9gknd 2008 15 collection collection NN cord-010119-t1x9gknd 2008 16 . . . cord-010119-t1x9gknd 2009 1 Multiple multiple JJ cord-010119-t1x9gknd 2009 2 regression regression NN cord-010119-t1x9gknd 2009 3 analysis analysis NN cord-010119-t1x9gknd 2009 4 including include VBG cord-010119-t1x9gknd 2009 5 the the DT cord-010119-t1x9gknd 2009 6 parameters parameter NNS cord-010119-t1x9gknd 2009 7 sex sex NN cord-010119-t1x9gknd 2009 8 , , , cord-010119-t1x9gknd 2009 9 age age NN cord-010119-t1x9gknd 2009 10 , , , cord-010119-t1x9gknd 2009 11 positive positive JJ cord-010119-t1x9gknd 2009 12 family family NN cord-010119-t1x9gknd 2009 13 history history NN cord-010119-t1x9gknd 2009 14 of of IN cord-010119-t1x9gknd 2009 15 bone bone NN cord-010119-t1x9gknd 2009 16 disease disease NN cord-010119-t1x9gknd 2009 17 , , , cord-010119-t1x9gknd 2009 18 but but CC cord-010119-t1x9gknd 2009 19 also also RB cord-010119-t1x9gknd 2009 20 individual individual JJ cord-010119-t1x9gknd 2009 21 factors factor NNS cord-010119-t1x9gknd 2009 22 like like IN cord-010119-t1x9gknd 2009 23 hormonal hormonal JJ cord-010119-t1x9gknd 2009 24 contraception contraception NN cord-010119-t1x9gknd 2009 25 , , , cord-010119-t1x9gknd 2009 26 smoking smoking NN cord-010119-t1x9gknd 2009 27 , , , cord-010119-t1x9gknd 2009 28 regular regular JJ cord-010119-t1x9gknd 2009 29 alcohol alcohol NN cord-010119-t1x9gknd 2009 30 consumption consumption NN cord-010119-t1x9gknd 2009 31 or or CC cord-010119-t1x9gknd 2009 32 sportive sportive JJ cord-010119-t1x9gknd 2009 33 activity activity NN cord-010119-t1x9gknd 2009 34 revealed reveal VBD cord-010119-t1x9gknd 2009 35 no no DT cord-010119-t1x9gknd 2009 36 influence influence NN cord-010119-t1x9gknd 2009 37 of of IN cord-010119-t1x9gknd 2009 38 socio socio JJ cord-010119-t1x9gknd 2009 39 - - HYPH cord-010119-t1x9gknd 2009 40 demographic demographic JJ cord-010119-t1x9gknd 2009 41 or or CC cord-010119-t1x9gknd 2009 42 lifestyle lifestyle NN cord-010119-t1x9gknd 2009 43 factors factor NNS cord-010119-t1x9gknd 2009 44 on on IN cord-010119-t1x9gknd 2009 45 the the DT cord-010119-t1x9gknd 2009 46 observed observed JJ cord-010119-t1x9gknd 2009 47 variation variation NN cord-010119-t1x9gknd 2009 48 in in IN cord-010119-t1x9gknd 2009 49 CTX CTX NNP cord-010119-t1x9gknd 2009 50 or or CC cord-010119-t1x9gknd 2009 51 OC OC NNP cord-010119-t1x9gknd 2009 52 . . . cord-010119-t1x9gknd 2010 1 There there EX cord-010119-t1x9gknd 2010 2 was be VBD cord-010119-t1x9gknd 2010 3 no no DT cord-010119-t1x9gknd 2010 4 association association NN cord-010119-t1x9gknd 2010 5 between between IN cord-010119-t1x9gknd 2010 6 individual individual JJ cord-010119-t1x9gknd 2010 7 donor donor NN cord-010119-t1x9gknd 2010 8 career career NN cord-010119-t1x9gknd 2010 9 or or CC cord-010119-t1x9gknd 2010 10 the the DT cord-010119-t1x9gknd 2010 11 number number NN cord-010119-t1x9gknd 2010 12 of of IN cord-010119-t1x9gknd 2010 13 previous previous JJ cord-010119-t1x9gknd 2010 14 donation donation NN cord-010119-t1x9gknd 2010 15 and and CC cord-010119-t1x9gknd 2010 16 the the DT cord-010119-t1x9gknd 2010 17 observed observed JJ cord-010119-t1x9gknd 2010 18 increase increase NN cord-010119-t1x9gknd 2010 19 in in IN cord-010119-t1x9gknd 2010 20 bone bone NN cord-010119-t1x9gknd 2010 21 turnover turnover NN cord-010119-t1x9gknd 2010 22 . . . cord-010119-t1x9gknd 2011 1 The the DT cord-010119-t1x9gknd 2011 2 only only JJ cord-010119-t1x9gknd 2011 3 predictive predictive JJ cord-010119-t1x9gknd 2011 4 parameter parameter NN cord-010119-t1x9gknd 2011 5 we -PRON- PRP cord-010119-t1x9gknd 2011 6 could could MD cord-010119-t1x9gknd 2011 7 identify identify VB cord-010119-t1x9gknd 2011 8 was be VBD cord-010119-t1x9gknd 2011 9 the the DT cord-010119-t1x9gknd 2011 10 amount amount NN cord-010119-t1x9gknd 2011 11 of of IN cord-010119-t1x9gknd 2011 12 citrate citrate NN cord-010119-t1x9gknd 2011 13 exposure exposure NN cord-010119-t1x9gknd 2011 14 during during IN cord-010119-t1x9gknd 2011 15 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 2011 16 . . . cord-010119-t1x9gknd 2012 1 Increase increase VB cord-010119-t1x9gknd 2012 2 in in IN cord-010119-t1x9gknd 2012 3 serum serum NN cord-010119-t1x9gknd 2012 4 CTX CTX NNP cord-010119-t1x9gknd 2012 5 , , , cord-010119-t1x9gknd 2012 6 showed show VBD cord-010119-t1x9gknd 2012 7 an an DT cord-010119-t1x9gknd 2012 8 inverse inverse JJ cord-010119-t1x9gknd 2012 9 correlation correlation NN cord-010119-t1x9gknd 2012 10 to to IN cord-010119-t1x9gknd 2012 11 changes change NNS cord-010119-t1x9gknd 2012 12 of of IN cord-010119-t1x9gknd 2012 13 serum serum NN cord-010119-t1x9gknd 2012 14 ionized ionized JJ cord-010119-t1x9gknd 2012 15 calcium calcium NN cord-010119-t1x9gknd 2012 16 . . . cord-010119-t1x9gknd 2013 1 Continuous continuous JJ cord-010119-t1x9gknd 2013 2 IV IV NNP cord-010119-t1x9gknd 2013 3 supplementation supplementation NN cord-010119-t1x9gknd 2013 4 of of IN cord-010119-t1x9gknd 2013 5 calcium calcium NN cord-010119-t1x9gknd 2013 6 - - HYPH cord-010119-t1x9gknd 2013 7 gluconate gluconate NN cord-010119-t1x9gknd 2013 8 throughout throughout IN cord-010119-t1x9gknd 2013 9 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 2013 10 reduced reduce VBD cord-010119-t1x9gknd 2013 11 the the DT cord-010119-t1x9gknd 2013 12 variations variation NNS cord-010119-t1x9gknd 2013 13 in in IN cord-010119-t1x9gknd 2013 14 bone bone NN cord-010119-t1x9gknd 2013 15 markers marker NNS cord-010119-t1x9gknd 2013 16 , , , cord-010119-t1x9gknd 2013 17 although although IN cord-010119-t1x9gknd 2013 18 this this DT cord-010119-t1x9gknd 2013 19 effect effect NN cord-010119-t1x9gknd 2013 20 was be VBD cord-010119-t1x9gknd 2013 21 more more RBR cord-010119-t1x9gknd 2013 22 pronounced pronounced JJ cord-010119-t1x9gknd 2013 23 for for IN cord-010119-t1x9gknd 2013 24 CTX CTX NNP cord-010119-t1x9gknd 2013 25 compared compare VBN cord-010119-t1x9gknd 2013 26 to to IN cord-010119-t1x9gknd 2013 27 OC OC NNP cord-010119-t1x9gknd 2013 28 . . . cord-010119-t1x9gknd 2014 1 Conclusion conclusion NN cord-010119-t1x9gknd 2014 2 : : : cord-010119-t1x9gknd 2015 1 The the DT cord-010119-t1x9gknd 2015 2 amount amount NN cord-010119-t1x9gknd 2015 3 of of IN cord-010119-t1x9gknd 2015 4 citrate citrate NN cord-010119-t1x9gknd 2015 5 infused infuse VBN cord-010119-t1x9gknd 2015 6 during during IN cord-010119-t1x9gknd 2015 7 routine routine JJ cord-010119-t1x9gknd 2015 8 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 2015 9 is be VBZ cord-010119-t1x9gknd 2015 10 a a DT cord-010119-t1x9gknd 2015 11 predictive predictive JJ cord-010119-t1x9gknd 2015 12 parameter parameter NN cord-010119-t1x9gknd 2015 13 for for IN cord-010119-t1x9gknd 2015 14 the the DT cord-010119-t1x9gknd 2015 15 transient transient JJ cord-010119-t1x9gknd 2015 16 increase increase NN cord-010119-t1x9gknd 2015 17 in in IN cord-010119-t1x9gknd 2015 18 serum serum NN cord-010119-t1x9gknd 2015 19 markers marker NNS cord-010119-t1x9gknd 2015 20 of of IN cord-010119-t1x9gknd 2015 21 bone bone NN cord-010119-t1x9gknd 2015 22 metabolism metabolism NN cord-010119-t1x9gknd 2015 23 . . . cord-010119-t1x9gknd 2016 1 Known know VBN cord-010119-t1x9gknd 2016 2 risk risk NN cord-010119-t1x9gknd 2016 3 factors factor NNS cord-010119-t1x9gknd 2016 4 for for IN cord-010119-t1x9gknd 2016 5 bone bone NN cord-010119-t1x9gknd 2016 6 diseases disease NNS cord-010119-t1x9gknd 2016 7 , , , cord-010119-t1x9gknd 2016 8 including include VBG cord-010119-t1x9gknd 2016 9 sex sex NN cord-010119-t1x9gknd 2016 10 , , , cord-010119-t1x9gknd 2016 11 age age NN cord-010119-t1x9gknd 2016 12 , , , cord-010119-t1x9gknd 2016 13 smoking smoking NN cord-010119-t1x9gknd 2016 14 or or CC cord-010119-t1x9gknd 2016 15 alcohol alcohol NN cord-010119-t1x9gknd 2016 16 consumption consumption NN cord-010119-t1x9gknd 2016 17 , , , cord-010119-t1x9gknd 2016 18 seems seem VBZ cord-010119-t1x9gknd 2016 19 to to TO cord-010119-t1x9gknd 2016 20 have have VB cord-010119-t1x9gknd 2016 21 a a DT cord-010119-t1x9gknd 2016 22 low low JJ cord-010119-t1x9gknd 2016 23 impact impact NN cord-010119-t1x9gknd 2016 24 on on IN cord-010119-t1x9gknd 2016 25 the the DT cord-010119-t1x9gknd 2016 26 observed observed JJ cord-010119-t1x9gknd 2016 27 citrate citrate NN cord-010119-t1x9gknd 2016 28 - - HYPH cord-010119-t1x9gknd 2016 29 related relate VBN cord-010119-t1x9gknd 2016 30 variations variation NNS cord-010119-t1x9gknd 2016 31 in in IN cord-010119-t1x9gknd 2016 32 serological serological JJ cord-010119-t1x9gknd 2016 33 biomarkers biomarker NNS cord-010119-t1x9gknd 2016 34 of of IN cord-010119-t1x9gknd 2016 35 bone bone NN cord-010119-t1x9gknd 2016 36 turnover turnover NN cord-010119-t1x9gknd 2016 37 . . . cord-010119-t1x9gknd 2017 1 Transfusion transfusion NN cord-010119-t1x9gknd 2017 2 with with IN cord-010119-t1x9gknd 2017 3 Optimized Optimized NNP cord-010119-t1x9gknd 2017 4 Blood Blood NNP cord-010119-t1x9gknd 2017 5 Products Products NNPS cord-010119-t1x9gknd 2017 6 Versus Versus NNP cord-010119-t1x9gknd 2017 7 Transfusion Transfusion NNP cord-010119-t1x9gknd 2017 8 with with IN cord-010119-t1x9gknd 2017 9 Standard Standard NNP cord-010119-t1x9gknd 2017 10 Products Products NNPS cord-010119-t1x9gknd 2017 11 in in IN cord-010119-t1x9gknd 2017 12 a a DT cord-010119-t1x9gknd 2017 13 Trauma Trauma NNP cord-010119-t1x9gknd 2017 14 - - HYPH cord-010119-t1x9gknd 2017 15 Transfusion Transfusion NNP cord-010119-t1x9gknd 2017 16 Rat Rat NNP cord-010119-t1x9gknd 2017 17 Model Model NNP cord-010119-t1x9gknd 2017 18 Mathijs Mathijs NNP cord-010119-t1x9gknd 2017 19 Wirtz Wirtz NNP cord-010119-t1x9gknd 2017 20 * * NFP cord-010119-t1x9gknd 2017 21 1 1 CD cord-010119-t1x9gknd 2017 22 , , , cord-010119-t1x9gknd 2017 23 Jordy Jordy NNP cord-010119-t1x9gknd 2017 24 Jurgens Jurgens NNP cord-010119-t1x9gknd 2017 25 1 1 CD cord-010119-t1x9gknd 2017 26 , , , cord-010119-t1x9gknd 2017 27 Jacoline Jacoline NNP cord-010119-t1x9gknd 2017 28 Buchner Buchner NNP cord-010119-t1x9gknd 2017 29 - - HYPH cord-010119-t1x9gknd 2017 30 Doeven Doeven NNP cord-010119-t1x9gknd 2017 31 1 1 CD cord-010119-t1x9gknd 2017 32 , , , cord-010119-t1x9gknd 2017 33 Joris Joris NNP cord-010119-t1x9gknd 2017 34 Roelofs Roelofs NNP cord-010119-t1x9gknd 2017 35 1 1 CD cord-010119-t1x9gknd 2017 36 , , , cord-010119-t1x9gknd 2017 37 Philip Philip NNP cord-010119-t1x9gknd 2017 38 Spinella Spinella NNP cord-010119-t1x9gknd 2017 39 2 2 CD cord-010119-t1x9gknd 2017 40 , , , cord-010119-t1x9gknd 2017 41 Jennifer Jennifer NNP cord-010119-t1x9gknd 2017 42 A A NNP cord-010119-t1x9gknd 2017 43 Muszynski Muszynski NNP cord-010119-t1x9gknd 2017 44 3 3 CD cord-010119-t1x9gknd 2017 45 , , , cord-010119-t1x9gknd 2017 46 Carel Carel NNP cord-010119-t1x9gknd 2017 47 Goslings Goslings NNP cord-010119-t1x9gknd 2017 48 1 1 CD cord-010119-t1x9gknd 2017 49 and and CC cord-010119-t1x9gknd 2017 50 Nicole Nicole NNP cord-010119-t1x9gknd 2017 51 Juffermans Juffermans NNP cord-010119-t1x9gknd 2017 52 1 1 CD cord-010119-t1x9gknd 2017 53 . . . cord-010119-t1x9gknd 2018 1 1 1 LS cord-010119-t1x9gknd 2018 2 Academic Academic NNP cord-010119-t1x9gknd 2018 3 Medical Medical NNP cord-010119-t1x9gknd 2018 4 Center Center NNP cord-010119-t1x9gknd 2018 5 , , , cord-010119-t1x9gknd 2018 6 2 2 CD cord-010119-t1x9gknd 2018 7 Washington Washington NNP cord-010119-t1x9gknd 2018 8 University University NNP cord-010119-t1x9gknd 2018 9 School School NNP cord-010119-t1x9gknd 2018 10 of of IN cord-010119-t1x9gknd 2018 11 Medicine Medicine NNP cord-010119-t1x9gknd 2018 12 , , , cord-010119-t1x9gknd 2018 13 3 3 CD cord-010119-t1x9gknd 2018 14 Nationwide Nationwide NNP cord-010119-t1x9gknd 2018 15 Children Children NNPS cord-010119-t1x9gknd 2018 16 's 's POS cord-010119-t1x9gknd 2018 17 Hospital Hospital NNP cord-010119-t1x9gknd 2018 18 Background Background NNP cord-010119-t1x9gknd 2018 19 / / SYM cord-010119-t1x9gknd 2018 20 Case Case NNP cord-010119-t1x9gknd 2018 21 Studies Studies NNPS cord-010119-t1x9gknd 2018 22 : : : cord-010119-t1x9gknd 2018 23 Transfusion transfusion NN cord-010119-t1x9gknd 2018 24 is be VBZ cord-010119-t1x9gknd 2018 25 associated associate VBN cord-010119-t1x9gknd 2018 26 with with IN cord-010119-t1x9gknd 2018 27 nosocomial nosocomial JJ cord-010119-t1x9gknd 2018 28 infection infection NN cord-010119-t1x9gknd 2018 29 and and CC cord-010119-t1x9gknd 2018 30 organ organ NN cord-010119-t1x9gknd 2018 31 dysfunction dysfunction NN cord-010119-t1x9gknd 2018 32 in in IN cord-010119-t1x9gknd 2018 33 trauma trauma NN cord-010119-t1x9gknd 2018 34 patients patient NNS cord-010119-t1x9gknd 2018 35 , , , cord-010119-t1x9gknd 2018 36 which which WDT cord-010119-t1x9gknd 2018 37 may may MD cord-010119-t1x9gknd 2018 38 be be VB cord-010119-t1x9gknd 2018 39 mediated mediate VBN cord-010119-t1x9gknd 2018 40 by by IN cord-010119-t1x9gknd 2018 41 soluble soluble JJ cord-010119-t1x9gknd 2018 42 bioactive bioactive JJ cord-010119-t1x9gknd 2018 43 substances substance NNS cord-010119-t1x9gknd 2018 44 in in IN cord-010119-t1x9gknd 2018 45 blood blood NN cord-010119-t1x9gknd 2018 46 products product NNS cord-010119-t1x9gknd 2018 47 . . . cord-010119-t1x9gknd 2019 1 We -PRON- PRP cord-010119-t1x9gknd 2019 2 hypothesized hypothesize VBD cord-010119-t1x9gknd 2019 3 that that IN cord-010119-t1x9gknd 2019 4 removing remove VBG cord-010119-t1x9gknd 2019 5 these these DT cord-010119-t1x9gknd 2019 6 bioactive bioactive JJ cord-010119-t1x9gknd 2019 7 substances substance NNS cord-010119-t1x9gknd 2019 8 improves improve VBZ cord-010119-t1x9gknd 2019 9 host host NN cord-010119-t1x9gknd 2019 10 immune immune JJ cord-010119-t1x9gknd 2019 11 response response NN cord-010119-t1x9gknd 2019 12 and and CC cord-010119-t1x9gknd 2019 13 reduces reduce VBZ cord-010119-t1x9gknd 2019 14 organ organ NN cord-010119-t1x9gknd 2019 15 dysfunction dysfunction NN cord-010119-t1x9gknd 2019 16 . . . cord-010119-t1x9gknd 2020 1 Study Study NNP cord-010119-t1x9gknd 2020 2 Design Design NNP cord-010119-t1x9gknd 2020 3 / / SYM cord-010119-t1x9gknd 2020 4 Methods method NNS cord-010119-t1x9gknd 2020 5 : : : cord-010119-t1x9gknd 2021 1 Blood blood NN cord-010119-t1x9gknd 2021 2 products product NNS cord-010119-t1x9gknd 2021 3 were be VBD cord-010119-t1x9gknd 2021 4 prepared prepare VBN cord-010119-t1x9gknd 2021 5 from from IN cord-010119-t1x9gknd 2021 6 syngeneic syngeneic NNS cord-010119-t1x9gknd 2021 7 rat rat NN cord-010119-t1x9gknd 2021 8 blood blood NN cord-010119-t1x9gknd 2021 9 according accord VBG cord-010119-t1x9gknd 2021 10 to to IN cord-010119-t1x9gknd 2021 11 blood blood NN cord-010119-t1x9gknd 2021 12 bank bank NN cord-010119-t1x9gknd 2021 13 standards standard NNS cord-010119-t1x9gknd 2021 14 . . . cord-010119-t1x9gknd 2022 1 Soluble soluble JJ cord-010119-t1x9gknd 2022 2 mediators mediator NNS cord-010119-t1x9gknd 2022 3 were be VBD cord-010119-t1x9gknd 2022 4 removed remove VBN cord-010119-t1x9gknd 2022 5 from from IN cord-010119-t1x9gknd 2022 6 red red JJ cord-010119-t1x9gknd 2022 7 blood blood NN cord-010119-t1x9gknd 2022 8 cells cell NNS cord-010119-t1x9gknd 2022 9 ( ( -LRB- cord-010119-t1x9gknd 2022 10 14 14 CD cord-010119-t1x9gknd 2022 11 days day NNS cord-010119-t1x9gknd 2022 12 old old JJ cord-010119-t1x9gknd 2022 13 ) ) -RRB- cord-010119-t1x9gknd 2022 14 and and CC cord-010119-t1x9gknd 2022 15 platelets platelet NNS cord-010119-t1x9gknd 2022 16 ( ( -LRB- cord-010119-t1x9gknd 2022 17 5 5 CD cord-010119-t1x9gknd 2022 18 days day NNS cord-010119-t1x9gknd 2022 19 old old JJ cord-010119-t1x9gknd 2022 20 ) ) -RRB- cord-010119-t1x9gknd 2022 21 by by IN cord-010119-t1x9gknd 2022 22 washing wash VBG cord-010119-t1x9gknd 2022 23 . . . cord-010119-t1x9gknd 2023 1 Plasma plasma NN cord-010119-t1x9gknd 2023 2 was be VBD cord-010119-t1x9gknd 2023 3 filtered filter VBN cord-010119-t1x9gknd 2023 4 through through IN cord-010119-t1x9gknd 2023 5 a a DT cord-010119-t1x9gknd 2023 6 0.22um 0.22um CD cord-010119-t1x9gknd 2023 7 filter filter NN cord-010119-t1x9gknd 2023 8 . . . cord-010119-t1x9gknd 2024 1 Rats rat NNS cord-010119-t1x9gknd 2024 2 ( ( -LRB- cord-010119-t1x9gknd 2024 3 $ $ $ cord-010119-t1x9gknd 2024 4 350 350 CD cord-010119-t1x9gknd 2024 5 grams gram NNS cord-010119-t1x9gknd 2024 6 ) ) -RRB- cord-010119-t1x9gknd 2024 7 were be VBD cord-010119-t1x9gknd 2024 8 poly poly NN cord-010119-t1x9gknd 2024 9 - - HYPH cord-010119-t1x9gknd 2024 10 traumatized traumatize VBN cord-010119-t1x9gknd 2024 11 by by IN cord-010119-t1x9gknd 2024 12 crush crush NN cord-010119-t1x9gknd 2024 13 injury injury NN cord-010119-t1x9gknd 2024 14 to to IN cord-010119-t1x9gknd 2024 15 the the DT cord-010119-t1x9gknd 2024 16 small small JJ cord-010119-t1x9gknd 2024 17 intestines intestine NNS cord-010119-t1x9gknd 2024 18 , , , cord-010119-t1x9gknd 2024 19 the the DT cord-010119-t1x9gknd 2024 20 liver liver NN cord-010119-t1x9gknd 2024 21 lobes lobe NNS cord-010119-t1x9gknd 2024 22 , , , cord-010119-t1x9gknd 2024 23 and and CC cord-010119-t1x9gknd 2024 24 by by IN cord-010119-t1x9gknd 2024 25 fracture fracture NN cord-010119-t1x9gknd 2024 26 of of IN cord-010119-t1x9gknd 2024 27 the the DT cord-010119-t1x9gknd 2024 28 right right JJ cord-010119-t1x9gknd 2024 29 femur femur NN cord-010119-t1x9gknd 2024 30 and and CC cord-010119-t1x9gknd 2024 31 hemorrhaged hemorrhage VBD cord-010119-t1x9gknd 2024 32 $ $ $ cord-010119-t1x9gknd 2024 33 30 30 CD cord-010119-t1x9gknd 2024 34 % % NN cord-010119-t1x9gknd 2024 35 of of IN cord-010119-t1x9gknd 2024 36 their -PRON- PRP$ cord-010119-t1x9gknd 2024 37 estimated estimate VBN cord-010119-t1x9gknd 2024 38 blood blood NN cord-010119-t1x9gknd 2024 39 volume volume NN cord-010119-t1x9gknd 2024 40 , , , cord-010119-t1x9gknd 2024 41 which which WDT cord-010119-t1x9gknd 2024 42 was be VBD cord-010119-t1x9gknd 2024 43 calculated calculate VBN cord-010119-t1x9gknd 2024 44 to to TO cord-010119-t1x9gknd 2024 45 be be VB cord-010119-t1x9gknd 2024 46 57mL 57ml CD cord-010119-t1x9gknd 2024 47 / / SYM cord-010119-t1x9gknd 2024 48 kg kg NNS cord-010119-t1x9gknd 2024 49 . . . cord-010119-t1x9gknd 2025 1 Hemorrhage hemorrhage NN cord-010119-t1x9gknd 2025 2 continued continue VBD cord-010119-t1x9gknd 2025 3 until until IN cord-010119-t1x9gknd 2025 4 a a DT cord-010119-t1x9gknd 2025 5 mean mean JJ cord-010119-t1x9gknd 2025 6 arterial arterial JJ cord-010119-t1x9gknd 2025 7 pressure pressure NN cord-010119-t1x9gknd 2025 8 of of IN cord-010119-t1x9gknd 2025 9 40mmHg 40mmhg CD cord-010119-t1x9gknd 2025 10 was be VBD cord-010119-t1x9gknd 2025 11 reached reach VBN cord-010119-t1x9gknd 2025 12 . . . cord-010119-t1x9gknd 2026 1 Rats rat NNS cord-010119-t1x9gknd 2026 2 were be VBD cord-010119-t1x9gknd 2026 3 randomized randomize VBN cord-010119-t1x9gknd 2026 4 to to IN cord-010119-t1x9gknd 2026 5 resuscitation resuscitation NN cord-010119-t1x9gknd 2026 6 with with IN cord-010119-t1x9gknd 2026 7 standard standard JJ cord-010119-t1x9gknd 2026 8 blood blood NN cord-010119-t1x9gknd 2026 9 products product NNS cord-010119-t1x9gknd 2026 10 , , , cord-010119-t1x9gknd 2026 11 washed wash VBD cord-010119-t1x9gknd 2026 12 / / SYM cord-010119-t1x9gknd 2026 13 filtered filter VBN cord-010119-t1x9gknd 2026 14 blood blood NN cord-010119-t1x9gknd 2026 15 products product NNS cord-010119-t1x9gknd 2026 16 or or CC cord-010119-t1x9gknd 2026 17 sham sham NN cord-010119-t1x9gknd 2026 18 . . . cord-010119-t1x9gknd 2027 1 Blood blood NN cord-010119-t1x9gknd 2027 2 samples sample NNS cord-010119-t1x9gknd 2027 3 were be VBD cord-010119-t1x9gknd 2027 4 taken take VBN cord-010119-t1x9gknd 2027 5 up up RP cord-010119-t1x9gknd 2027 6 to to IN cord-010119-t1x9gknd 2027 7 4h 4h CD cord-010119-t1x9gknd 2027 8 after after IN cord-010119-t1x9gknd 2027 9 trauma trauma NN cord-010119-t1x9gknd 2027 10 to to TO cord-010119-t1x9gknd 2027 11 assess assess VB cord-010119-t1x9gknd 2027 12 biochemistry biochemistry NN cord-010119-t1x9gknd 2027 13 and and CC cord-010119-t1x9gknd 2027 14 coagulation coagulation NN cord-010119-t1x9gknd 2027 15 status status NN cord-010119-t1x9gknd 2027 16 . . . cord-010119-t1x9gknd 2028 1 Ex Ex NNP cord-010119-t1x9gknd 2028 2 vivo vivo FW cord-010119-t1x9gknd 2028 3 whole whole JJ cord-010119-t1x9gknd 2028 4 blood blood NN cord-010119-t1x9gknd 2028 5 stimulation stimulation NN cord-010119-t1x9gknd 2028 6 tests test NNS cord-010119-t1x9gknd 2028 7 with with IN cord-010119-t1x9gknd 2028 8 LPS LPS NNP cord-010119-t1x9gknd 2028 9 were be VBD cord-010119-t1x9gknd 2028 10 performed perform VBN cord-010119-t1x9gknd 2028 11 after after IN cord-010119-t1x9gknd 2028 12 sacrifice sacrifice NN cord-010119-t1x9gknd 2028 13 , , , cord-010119-t1x9gknd 2028 14 and and CC cord-010119-t1x9gknd 2028 15 organ organ NN cord-010119-t1x9gknd 2028 16 damage damage NN cord-010119-t1x9gknd 2028 17 was be VBD cord-010119-t1x9gknd 2028 18 assessed assess VBN cord-010119-t1x9gknd 2028 19 by by IN cord-010119-t1x9gknd 2028 20 histopathology histopathology NN cord-010119-t1x9gknd 2028 21 . . . cord-010119-t1x9gknd 2029 1 Blood blood NN cord-010119-t1x9gknd 2029 2 products product NNS cord-010119-t1x9gknd 2029 3 were be VBD cord-010119-t1x9gknd 2029 4 sampled sample VBN cord-010119-t1x9gknd 2029 5 to to TO cord-010119-t1x9gknd 2029 6 assess assess VB cord-010119-t1x9gknd 2029 7 for for IN cord-010119-t1x9gknd 2029 8 biochemical biochemical JJ cord-010119-t1x9gknd 2029 9 changes change NNS cord-010119-t1x9gknd 2029 10 . . . cord-010119-t1x9gknd 2030 1 Comparisons comparison NNS cord-010119-t1x9gknd 2030 2 between between IN cord-010119-t1x9gknd 2030 3 groups group NNS cord-010119-t1x9gknd 2030 4 was be VBD cord-010119-t1x9gknd 2030 5 done do VBN cord-010119-t1x9gknd 2030 6 by by IN cord-010119-t1x9gknd 2030 7 ANOVA ANOVA NNP cord-010119-t1x9gknd 2030 8 and and CC cord-010119-t1x9gknd 2030 9 Dunnett Dunnett NNP cord-010119-t1x9gknd 2030 10 's 's POS cord-010119-t1x9gknd 2030 11 post post JJ cord-010119-t1x9gknd 2030 12 - - JJ cord-010119-t1x9gknd 2030 13 test test NN cord-010119-t1x9gknd 2030 14 for for IN cord-010119-t1x9gknd 2030 15 multiple multiple JJ cord-010119-t1x9gknd 2030 16 comparisons comparison NNS cord-010119-t1x9gknd 2030 17 . . . cord-010119-t1x9gknd 2031 1 Results result NNS cord-010119-t1x9gknd 2031 2 / / SYM cord-010119-t1x9gknd 2031 3 Findings finding NNS cord-010119-t1x9gknd 2031 4 : : : cord-010119-t1x9gknd 2032 1 Filtering filter VBG cord-010119-t1x9gknd 2032 2 or or CC cord-010119-t1x9gknd 2032 3 washing washing NN cord-010119-t1x9gknd 2032 4 of of IN cord-010119-t1x9gknd 2032 5 blood blood NN cord-010119-t1x9gknd 2032 6 products product NNS cord-010119-t1x9gknd 2032 7 significantly significantly RB cord-010119-t1x9gknd 2032 8 stabilized stabilize VBD cord-010119-t1x9gknd 2032 9 pH ph NN cord-010119-t1x9gknd 2032 10 , , , cord-010119-t1x9gknd 2032 11 sodium sodium NN cord-010119-t1x9gknd 2032 12 and and CC cord-010119-t1x9gknd 2032 13 potassium potassium NN cord-010119-t1x9gknd 2032 14 concentrations concentration NNS cord-010119-t1x9gknd 2032 15 and and CC cord-010119-t1x9gknd 2032 16 decreased decrease VBD cord-010119-t1x9gknd 2032 17 lactate lactate NN cord-010119-t1x9gknd 2032 18 levels level NNS cord-010119-t1x9gknd 2032 19 in in IN cord-010119-t1x9gknd 2032 20 the the DT cord-010119-t1x9gknd 2032 21 products product NNS cord-010119-t1x9gknd 2032 22 compared compare VBN cord-010119-t1x9gknd 2032 23 to to IN cord-010119-t1x9gknd 2032 24 standard standard JJ cord-010119-t1x9gknd 2032 25 products product NNS cord-010119-t1x9gknd 2032 26 . . . cord-010119-t1x9gknd 2033 1 Both both DT cord-010119-t1x9gknd 2033 2 resuscitation resuscitation NN cord-010119-t1x9gknd 2033 3 groups group NNS cord-010119-t1x9gknd 2033 4 received receive VBD cord-010119-t1x9gknd 2033 5 an an DT cord-010119-t1x9gknd 2033 6 average average NN cord-010119-t1x9gknd 2033 7 of of IN cord-010119-t1x9gknd 2033 8 17mL 17ml CD cord-010119-t1x9gknd 2033 9 / / SYM cord-010119-t1x9gknd 2033 10 kg kg NNS cord-010119-t1x9gknd 2033 11 of of IN cord-010119-t1x9gknd 2033 12 blood blood NN cord-010119-t1x9gknd 2033 13 products product NNS cord-010119-t1x9gknd 2033 14 in in IN cord-010119-t1x9gknd 2033 15 a a DT cord-010119-t1x9gknd 2033 16 1:1:1 1:1:1 CD cord-010119-t1x9gknd 2033 17 ratio ratio NN cord-010119-t1x9gknd 2033 18 . . . cord-010119-t1x9gknd 2034 1 However however RB cord-010119-t1x9gknd 2034 2 , , , cord-010119-t1x9gknd 2034 3 use use NN cord-010119-t1x9gknd 2034 4 of of IN cord-010119-t1x9gknd 2034 5 washed wash VBN cord-010119-t1x9gknd 2034 6 / / SYM cord-010119-t1x9gknd 2034 7 filtered filter VBN cord-010119-t1x9gknd 2034 8 products product NNS cord-010119-t1x9gknd 2034 9 did do VBD cord-010119-t1x9gknd 2034 10 not not RB cord-010119-t1x9gknd 2034 11 improve improve VB cord-010119-t1x9gknd 2034 12 organ organ NN cord-010119-t1x9gknd 2034 13 failure failure NN cord-010119-t1x9gknd 2034 14 , , , cord-010119-t1x9gknd 2034 15 as as IN cord-010119-t1x9gknd 2034 16 assessed assess VBN cord-010119-t1x9gknd 2034 17 by by IN cord-010119-t1x9gknd 2034 18 histopathologic histopathologic JJ cord-010119-t1x9gknd 2034 19 score score NN cord-010119-t1x9gknd 2034 20 and and CC cord-010119-t1x9gknd 2034 21 levels level NNS cord-010119-t1x9gknd 2034 22 of of IN cord-010119-t1x9gknd 2034 23 creatinine creatinine NN cord-010119-t1x9gknd 2034 24 , , , cord-010119-t1x9gknd 2034 25 ASAT ASAT NNP cord-010119-t1x9gknd 2034 26 and and CC cord-010119-t1x9gknd 2034 27 ALAT ALAT NNP cord-010119-t1x9gknd 2034 28 . . . cord-010119-t1x9gknd 2035 1 The the DT cord-010119-t1x9gknd 2035 2 coagulation coagulation NN cord-010119-t1x9gknd 2035 3 status status NN cord-010119-t1x9gknd 2035 4 as as IN cord-010119-t1x9gknd 2035 5 assessed assess VBN cord-010119-t1x9gknd 2035 6 by by IN cord-010119-t1x9gknd 2035 7 thromboelastometry thromboelastometry NNP cord-010119-t1x9gknd 2035 8 was be VBD cord-010119-t1x9gknd 2035 9 deranged deranged JJ cord-010119-t1x9gknd 2035 10 in in IN cord-010119-t1x9gknd 2035 11 all all DT cord-010119-t1x9gknd 2035 12 groups group NNS cord-010119-t1x9gknd 2035 13 and and CC cord-010119-t1x9gknd 2035 14 normalized normalize VBD cord-010119-t1x9gknd 2035 15 during during IN cord-010119-t1x9gknd 2035 16 transfusion transfusion NN cord-010119-t1x9gknd 2035 17 , , , cord-010119-t1x9gknd 2035 18 showing show VBG cord-010119-t1x9gknd 2035 19 no no DT cord-010119-t1x9gknd 2035 20 significant significant JJ cord-010119-t1x9gknd 2035 21 differences difference NNS cord-010119-t1x9gknd 2035 22 between between IN cord-010119-t1x9gknd 2035 23 washed wash VBN cord-010119-t1x9gknd 2035 24 / / SYM cord-010119-t1x9gknd 2035 25 filtered filter VBN cord-010119-t1x9gknd 2035 26 products product NNS cord-010119-t1x9gknd 2035 27 and and CC cord-010119-t1x9gknd 2035 28 standard standard JJ cord-010119-t1x9gknd 2035 29 care care NN cord-010119-t1x9gknd 2035 30 . . . cord-010119-t1x9gknd 2036 1 Immune immune JJ cord-010119-t1x9gknd 2036 2 response response NN cord-010119-t1x9gknd 2036 3 to to IN cord-010119-t1x9gknd 2036 4 LPS LPS NNP cord-010119-t1x9gknd 2036 5 was be VBD cord-010119-t1x9gknd 2036 6 decreased decrease VBN cord-010119-t1x9gknd 2036 7 following follow VBG cord-010119-t1x9gknd 2036 8 trauma trauma NN cord-010119-t1x9gknd 2036 9 compared compare VBN cord-010119-t1x9gknd 2036 10 to to IN cord-010119-t1x9gknd 2036 11 healthy healthy JJ cord-010119-t1x9gknd 2036 12 controls control NNS cord-010119-t1x9gknd 2036 13 but but CC cord-010119-t1x9gknd 2036 14 did do VBD cord-010119-t1x9gknd 2036 15 not not RB cord-010119-t1x9gknd 2036 16 differ differ VB cord-010119-t1x9gknd 2036 17 between between IN cord-010119-t1x9gknd 2036 18 groups group NNS cord-010119-t1x9gknd 2036 19 . . . cord-010119-t1x9gknd 2037 1 Conclusion conclusion NN cord-010119-t1x9gknd 2037 2 : : : cord-010119-t1x9gknd 2038 1 Filtering filter VBG cord-010119-t1x9gknd 2038 2 or or CC cord-010119-t1x9gknd 2038 3 washing washing NN cord-010119-t1x9gknd 2038 4 of of IN cord-010119-t1x9gknd 2038 5 blood blood NN cord-010119-t1x9gknd 2038 6 products product NNS cord-010119-t1x9gknd 2038 7 reduces reduce VBZ cord-010119-t1x9gknd 2038 8 some some DT cord-010119-t1x9gknd 2038 9 aspects aspect NNS cord-010119-t1x9gknd 2038 10 of of IN cord-010119-t1x9gknd 2038 11 storage storage NN cord-010119-t1x9gknd 2038 12 lesion lesion NN cord-010119-t1x9gknd 2038 13 of of IN cord-010119-t1x9gknd 2038 14 blood blood NN cord-010119-t1x9gknd 2038 15 products product NNS cord-010119-t1x9gknd 2038 16 , , , cord-010119-t1x9gknd 2038 17 without without IN cord-010119-t1x9gknd 2038 18 affecting affect VBG cord-010119-t1x9gknd 2038 19 the the DT cord-010119-t1x9gknd 2038 20 hemostatic hemostatic JJ cord-010119-t1x9gknd 2038 21 capacity capacity NN cord-010119-t1x9gknd 2038 22 of of IN cord-010119-t1x9gknd 2038 23 the the DT cord-010119-t1x9gknd 2038 24 products product NNS cord-010119-t1x9gknd 2038 25 , , , cord-010119-t1x9gknd 2038 26 but but CC cord-010119-t1x9gknd 2038 27 does do VBZ cord-010119-t1x9gknd 2038 28 not not RB cord-010119-t1x9gknd 2038 29 improve improve VB cord-010119-t1x9gknd 2038 30 organ organ NN cord-010119-t1x9gknd 2038 31 injury injury NN cord-010119-t1x9gknd 2038 32 in in IN cord-010119-t1x9gknd 2038 33 a a DT cord-010119-t1x9gknd 2038 34 rat rat NN cord-010119-t1x9gknd 2038 35 trauma trauma NN cord-010119-t1x9gknd 2038 36 and and CC cord-010119-t1x9gknd 2038 37 transfusion transfusion NN cord-010119-t1x9gknd 2038 38 model model NN cord-010119-t1x9gknd 2038 39 , , , cord-010119-t1x9gknd 2038 40 nor nor CC cord-010119-t1x9gknd 2038 41 does do VBZ cord-010119-t1x9gknd 2038 42 it -PRON- PRP cord-010119-t1x9gknd 2038 43 improve improve VB cord-010119-t1x9gknd 2038 44 the the DT cord-010119-t1x9gknd 2038 45 immunosuppressive immunosuppressive JJ cord-010119-t1x9gknd 2038 46 host host NN cord-010119-t1x9gknd 2038 47 response response NN cord-010119-t1x9gknd 2038 48 . . . cord-010119-t1x9gknd 2039 1 These these DT cord-010119-t1x9gknd 2039 2 results result NNS cord-010119-t1x9gknd 2039 3 suggest suggest VBP cord-010119-t1x9gknd 2039 4 that that IN cord-010119-t1x9gknd 2039 5 washing washing NN cord-010119-t1x9gknd 2039 6 or or CC cord-010119-t1x9gknd 2039 7 filtering filtering NN cord-010119-t1x9gknd 2039 8 of of IN cord-010119-t1x9gknd 2039 9 blood blood NN cord-010119-t1x9gknd 2039 10 products product NNS cord-010119-t1x9gknd 2039 11 may may MD cord-010119-t1x9gknd 2039 12 have have VB cord-010119-t1x9gknd 2039 13 no no DT cord-010119-t1x9gknd 2039 14 relevant relevant JJ cord-010119-t1x9gknd 2039 15 clinical clinical JJ cord-010119-t1x9gknd 2039 16 effects effect NNS cord-010119-t1x9gknd 2039 17 in in IN cord-010119-t1x9gknd 2039 18 a a DT cord-010119-t1x9gknd 2039 19 rat rat NN cord-010119-t1x9gknd 2039 20 polytrauma polytrauma NN cord-010119-t1x9gknd 2039 21 model model NN cord-010119-t1x9gknd 2039 22 . . . cord-010119-t1x9gknd 2040 1 Safety Safety NNP cord-010119-t1x9gknd 2040 2 and and CC cord-010119-t1x9gknd 2040 3 Efficacy Efficacy NNP cord-010119-t1x9gknd 2040 4 of of IN cord-010119-t1x9gknd 2040 5 Tranexamic Tranexamic NNP cord-010119-t1x9gknd 2040 6 Acid Acid NNP cord-010119-t1x9gknd 2040 7 during during IN cord-010119-t1x9gknd 2040 8 Cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2040 9 Surgery surgery NN cord-010119-t1x9gknd 2040 10 : : : cord-010119-t1x9gknd 2040 11 A a DT cord-010119-t1x9gknd 2040 12 Single Single NNP cord-010119-t1x9gknd 2040 13 Center Center NNP cord-010119-t1x9gknd 2040 14 before before IN cord-010119-t1x9gknd 2040 15 - - HYPH cord-010119-t1x9gknd 2040 16 and and CC cord-010119-t1x9gknd 2040 17 - - HYPH cord-010119-t1x9gknd 2040 18 after after IN cord-010119-t1x9gknd 2040 19 Study Study NNP cord-010119-t1x9gknd 2040 20 Takuma Takuma NNP cord-010119-t1x9gknd 2040 21 Maeda Maeda NNP cord-010119-t1x9gknd 2040 22 * * NFP cord-010119-t1x9gknd 2040 23 and and CC cord-010119-t1x9gknd 2040 24 Shigeki Shigeki NNP cord-010119-t1x9gknd 2040 25 Miyata Miyata NNP cord-010119-t1x9gknd 2040 26 . . . cord-010119-t1x9gknd 2041 1 National National NNP cord-010119-t1x9gknd 2041 2 Cerebral Cerebral NNP cord-010119-t1x9gknd 2041 3 and and CC cord-010119-t1x9gknd 2041 4 Cardiovascular Cardiovascular NNP cord-010119-t1x9gknd 2041 5 Center Center NNP cord-010119-t1x9gknd 2041 6 Background Background NNP cord-010119-t1x9gknd 2041 7 / / SYM cord-010119-t1x9gknd 2041 8 Case Case NNP cord-010119-t1x9gknd 2041 9 Studies Studies NNPS cord-010119-t1x9gknd 2041 10 : : : cord-010119-t1x9gknd 2041 11 Tranexamic tranexamic JJ cord-010119-t1x9gknd 2041 12 acid acid NN cord-010119-t1x9gknd 2041 13 ( ( -LRB- cord-010119-t1x9gknd 2041 14 TXA TXA NNP cord-010119-t1x9gknd 2041 15 ) ) -RRB- cord-010119-t1x9gknd 2041 16 , , , cord-010119-t1x9gknd 2041 17 an an DT cord-010119-t1x9gknd 2041 18 antifibrinolytic antifibrinolytic JJ cord-010119-t1x9gknd 2041 19 agent agent NN cord-010119-t1x9gknd 2041 20 , , , cord-010119-t1x9gknd 2041 21 has have VBZ cord-010119-t1x9gknd 2041 22 been be VBN cord-010119-t1x9gknd 2041 23 widely widely RB cord-010119-t1x9gknd 2041 24 used use VBN cord-010119-t1x9gknd 2041 25 in in IN cord-010119-t1x9gknd 2041 26 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2041 27 surgery surgery NN cord-010119-t1x9gknd 2041 28 , , , cord-010119-t1x9gknd 2041 29 since since IN cord-010119-t1x9gknd 2041 30 several several JJ cord-010119-t1x9gknd 2041 31 studies study NNS cord-010119-t1x9gknd 2041 32 have have VBP cord-010119-t1x9gknd 2041 33 shown show VBN cord-010119-t1x9gknd 2041 34 that that IN cord-010119-t1x9gknd 2041 35 prophylactic prophylactic JJ cord-010119-t1x9gknd 2041 36 use use NN cord-010119-t1x9gknd 2041 37 of of IN cord-010119-t1x9gknd 2041 38 TXA TXA NNP cord-010119-t1x9gknd 2041 39 is be VBZ cord-010119-t1x9gknd 2041 40 effective effective JJ cord-010119-t1x9gknd 2041 41 in in IN cord-010119-t1x9gknd 2041 42 reducing reduce VBG cord-010119-t1x9gknd 2041 43 blood blood NN cord-010119-t1x9gknd 2041 44 loss loss NN cord-010119-t1x9gknd 2041 45 after after IN cord-010119-t1x9gknd 2041 46 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2041 47 surgery surgery NN cord-010119-t1x9gknd 2041 48 . . . cord-010119-t1x9gknd 2042 1 However however RB cord-010119-t1x9gknd 2042 2 , , , cord-010119-t1x9gknd 2042 3 there there EX cord-010119-t1x9gknd 2042 4 is be VBZ cord-010119-t1x9gknd 2042 5 concern concern NN cord-010119-t1x9gknd 2042 6 about about IN cord-010119-t1x9gknd 2042 7 the the DT cord-010119-t1x9gknd 2042 8 risk risk NN cord-010119-t1x9gknd 2042 9 of of IN cord-010119-t1x9gknd 2042 10 thromboembolic thromboembolic JJ cord-010119-t1x9gknd 2042 11 events event NNS cord-010119-t1x9gknd 2042 12 and and CC cord-010119-t1x9gknd 2042 13 adverse adverse JJ cord-010119-t1x9gknd 2042 14 neurological neurological JJ cord-010119-t1x9gknd 2042 15 effects effect NNS cord-010119-t1x9gknd 2042 16 such such JJ cord-010119-t1x9gknd 2042 17 as as IN cord-010119-t1x9gknd 2042 18 seizures seizure NNS cord-010119-t1x9gknd 2042 19 , , , cord-010119-t1x9gknd 2042 20 which which WDT cord-010119-t1x9gknd 2042 21 might may MD cord-010119-t1x9gknd 2042 22 worsen worsen VB cord-010119-t1x9gknd 2042 23 patient patient JJ cord-010119-t1x9gknd 2042 24 outcomes outcome NNS cord-010119-t1x9gknd 2042 25 . . . cord-010119-t1x9gknd 2043 1 Consequently consequently RB cord-010119-t1x9gknd 2043 2 , , , cord-010119-t1x9gknd 2043 3 we -PRON- PRP cord-010119-t1x9gknd 2043 4 stopped stop VBD cord-010119-t1x9gknd 2043 5 using use VBG cord-010119-t1x9gknd 2043 6 TXA TXA NNP cord-010119-t1x9gknd 2043 7 in in IN cord-010119-t1x9gknd 2043 8 April April NNP cord-010119-t1x9gknd 2043 9 2013 2013 CD cord-010119-t1x9gknd 2043 10 , , , cord-010119-t1x9gknd 2043 11 which which WDT cord-010119-t1x9gknd 2043 12 enabled enable VBD cord-010119-t1x9gknd 2043 13 us -PRON- PRP cord-010119-t1x9gknd 2043 14 to to TO cord-010119-t1x9gknd 2043 15 conduct conduct VB cord-010119-t1x9gknd 2043 16 a a DT cord-010119-t1x9gknd 2043 17 before before NN cord-010119-t1x9gknd 2043 18 - - HYPH cord-010119-t1x9gknd 2043 19 and and CC cord-010119-t1x9gknd 2043 20 - - HYPH cord-010119-t1x9gknd 2043 21 after after IN cord-010119-t1x9gknd 2043 22 study study NN cord-010119-t1x9gknd 2043 23 . . . cord-010119-t1x9gknd 2044 1 The the DT cord-010119-t1x9gknd 2044 2 present present JJ cord-010119-t1x9gknd 2044 3 study study NN cord-010119-t1x9gknd 2044 4 aimed aim VBN cord-010119-t1x9gknd 2044 5 to to TO cord-010119-t1x9gknd 2044 6 examine examine VB cord-010119-t1x9gknd 2044 7 the the DT cord-010119-t1x9gknd 2044 8 association association NN cord-010119-t1x9gknd 2044 9 between between IN cord-010119-t1x9gknd 2044 10 TXA TXA NNP cord-010119-t1x9gknd 2044 11 and and CC cord-010119-t1x9gknd 2044 12 adverse adverse JJ cord-010119-t1x9gknd 2044 13 effects effect NNS cord-010119-t1x9gknd 2044 14 ( ( -LRB- cord-010119-t1x9gknd 2044 15 seizures seizure NNS cord-010119-t1x9gknd 2044 16 , , , cord-010119-t1x9gknd 2044 17 thromboembolism thromboembolism NN cord-010119-t1x9gknd 2044 18 , , , cord-010119-t1x9gknd 2044 19 and and CC cord-010119-t1x9gknd 2044 20 renal renal JJ cord-010119-t1x9gknd 2044 21 dysfunction dysfunction NN cord-010119-t1x9gknd 2044 22 ) ) -RRB- cord-010119-t1x9gknd 2044 23 in in IN cord-010119-t1x9gknd 2044 24 patients patient NNS cord-010119-t1x9gknd 2044 25 undergoing undergo VBG cord-010119-t1x9gknd 2044 26 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2044 27 surgery surgery NN cord-010119-t1x9gknd 2044 28 using use VBG cord-010119-t1x9gknd 2044 29 a a DT cord-010119-t1x9gknd 2044 30 propensity propensity NN cord-010119-t1x9gknd 2044 31 score score NN cord-010119-t1x9gknd 2044 32 matching matching NN cord-010119-t1x9gknd 2044 33 model model NN cord-010119-t1x9gknd 2044 34 . . . cord-010119-t1x9gknd 2045 1 We -PRON- PRP cord-010119-t1x9gknd 2045 2 also also RB cord-010119-t1x9gknd 2045 3 assessed assess VBD cord-010119-t1x9gknd 2045 4 the the DT cord-010119-t1x9gknd 2045 5 association association NN cord-010119-t1x9gknd 2045 6 between between IN cord-010119-t1x9gknd 2045 7 TXA TXA NNP cord-010119-t1x9gknd 2045 8 and and CC cord-010119-t1x9gknd 2045 9 other other JJ cord-010119-t1x9gknd 2045 10 clinical clinical JJ cord-010119-t1x9gknd 2045 11 outcomes outcome NNS cord-010119-t1x9gknd 2045 12 ( ( -LRB- cord-010119-t1x9gknd 2045 13 reoperation reoperation NN cord-010119-t1x9gknd 2045 14 for for IN cord-010119-t1x9gknd 2045 15 bleeding bleed VBG cord-010119-t1x9gknd 2045 16 , , , cord-010119-t1x9gknd 2045 17 transfusion transfusion NN cord-010119-t1x9gknd 2045 18 volume volume NN cord-010119-t1x9gknd 2045 19 , , , cord-010119-t1x9gknd 2045 20 blood blood NN cord-010119-t1x9gknd 2045 21 loss loss NN cord-010119-t1x9gknd 2045 22 , , , cord-010119-t1x9gknd 2045 23 ventilation ventilation NN cord-010119-t1x9gknd 2045 24 time time NN cord-010119-t1x9gknd 2045 25 , , , cord-010119-t1x9gknd 2045 26 intensive intensive JJ cord-010119-t1x9gknd 2045 27 care care NN cord-010119-t1x9gknd 2045 28 unit unit NN cord-010119-t1x9gknd 2045 29 stay stay NN cord-010119-t1x9gknd 2045 30 , , , cord-010119-t1x9gknd 2045 31 and and CC cord-010119-t1x9gknd 2045 32 30-day 30-day CD cord-010119-t1x9gknd 2045 33 mortality mortality NN cord-010119-t1x9gknd 2045 34 ) ) -RRB- cord-010119-t1x9gknd 2045 35 . . . cord-010119-t1x9gknd 2046 1 Study Study NNP cord-010119-t1x9gknd 2046 2 Design Design NNP cord-010119-t1x9gknd 2046 3 / / SYM cord-010119-t1x9gknd 2046 4 Method method NN cord-010119-t1x9gknd 2046 5 : : : cord-010119-t1x9gknd 2047 1 This this DT cord-010119-t1x9gknd 2047 2 single single JJ cord-010119-t1x9gknd 2047 3 center center NN cord-010119-t1x9gknd 2047 4 retrospective retrospective JJ cord-010119-t1x9gknd 2047 5 cohort cohort NN cord-010119-t1x9gknd 2047 6 study study NN cord-010119-t1x9gknd 2047 7 involved involve VBD cord-010119-t1x9gknd 2047 8 patients patient NNS cord-010119-t1x9gknd 2047 9 who who WP cord-010119-t1x9gknd 2047 10 underwent undergo VBD cord-010119-t1x9gknd 2047 11 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2047 12 surgery surgery NN cord-010119-t1x9gknd 2047 13 with with IN cord-010119-t1x9gknd 2047 14 cardiopulmonary cardiopulmonary JJ cord-010119-t1x9gknd 2047 15 bypass bypass NN cord-010119-t1x9gknd 2047 16 or or CC cord-010119-t1x9gknd 2047 17 offpump offpump JJ cord-010119-t1x9gknd 2047 18 coronary coronary JJ cord-010119-t1x9gknd 2047 19 artery artery NN cord-010119-t1x9gknd 2047 20 bypass bypass NN cord-010119-t1x9gknd 2047 21 grafting grafting NN cord-010119-t1x9gknd 2047 22 between between IN cord-010119-t1x9gknd 2047 23 January January NNP cord-010119-t1x9gknd 2047 24 2008 2008 CD cord-010119-t1x9gknd 2047 25 and and CC cord-010119-t1x9gknd 2047 26 July July NNP cord-010119-t1x9gknd 2047 27 2015 2015 CD cord-010119-t1x9gknd 2047 28 ( ( -LRB- cord-010119-t1x9gknd 2047 29 n53535 n53535 NN cord-010119-t1x9gknd 2047 30 ) ) -RRB- cord-010119-t1x9gknd 2047 31 . . . cord-010119-t1x9gknd 2048 1 Because because IN cord-010119-t1x9gknd 2048 2 of of IN cord-010119-t1x9gknd 2048 3 missing miss VBG cord-010119-t1x9gknd 2048 4 data datum NNS cord-010119-t1x9gknd 2048 5 on on IN cord-010119-t1x9gknd 2048 6 patient patient JJ cord-010119-t1x9gknd 2048 7 characteristics characteristic NNS cord-010119-t1x9gknd 2048 8 , , , cord-010119-t1x9gknd 2048 9 257 257 CD cord-010119-t1x9gknd 2048 10 patients patient NNS cord-010119-t1x9gknd 2048 11 were be VBD cord-010119-t1x9gknd 2048 12 excluded exclude VBN cord-010119-t1x9gknd 2048 13 . . . cord-010119-t1x9gknd 2049 1 The the DT cord-010119-t1x9gknd 2049 2 incidence incidence NN cord-010119-t1x9gknd 2049 3 of of IN cord-010119-t1x9gknd 2049 4 adverse adverse JJ cord-010119-t1x9gknd 2049 5 effects effect NNS cord-010119-t1x9gknd 2049 6 associated associate VBN cord-010119-t1x9gknd 2049 7 with with IN cord-010119-t1x9gknd 2049 8 TXA TXA NNP cord-010119-t1x9gknd 2049 9 and and CC cord-010119-t1x9gknd 2049 10 other other JJ cord-010119-t1x9gknd 2049 11 clinical clinical JJ cord-010119-t1x9gknd 2049 12 outcomes outcome NNS cord-010119-t1x9gknd 2049 13 were be VBD cord-010119-t1x9gknd 2049 14 evaluated evaluate VBN cord-010119-t1x9gknd 2049 15 before before IN cord-010119-t1x9gknd 2049 16 ( ( -LRB- cord-010119-t1x9gknd 2049 17 January January NNP cord-010119-t1x9gknd 2049 18 2008 2008 CD cord-010119-t1x9gknd 2049 19 to to IN cord-010119-t1x9gknd 2049 20 March March NNP cord-010119-t1x9gknd 2049 21 2013 2013 CD cord-010119-t1x9gknd 2049 22 , , , cord-010119-t1x9gknd 2049 23 n51987 n51987 NNP cord-010119-t1x9gknd 2049 24 ) ) -RRB- cord-010119-t1x9gknd 2049 25 and and CC cord-010119-t1x9gknd 2049 26 after after IN cord-010119-t1x9gknd 2049 27 ( ( -LRB- cord-010119-t1x9gknd 2049 28 April April NNP cord-010119-t1x9gknd 2049 29 2013 2013 CD cord-010119-t1x9gknd 2049 30 to to IN cord-010119-t1x9gknd 2049 31 July July NNP cord-010119-t1x9gknd 2049 32 2015 2015 CD cord-010119-t1x9gknd 2049 33 , , , cord-010119-t1x9gknd 2049 34 n51291 n51291 NNP cord-010119-t1x9gknd 2049 35 ) ) -RRB- cord-010119-t1x9gknd 2049 36 using use VBG cord-010119-t1x9gknd 2049 37 a a DT cord-010119-t1x9gknd 2049 38 propensity propensity NN cord-010119-t1x9gknd 2049 39 score score NN cord-010119-t1x9gknd 2049 40 model model NN cord-010119-t1x9gknd 2049 41 . . . cord-010119-t1x9gknd 2050 1 We -PRON- PRP cord-010119-t1x9gknd 2050 2 estimated estimate VBD cord-010119-t1x9gknd 2050 3 propensity propensity NN cord-010119-t1x9gknd 2050 4 scores score NNS cord-010119-t1x9gknd 2050 5 using use VBG cord-010119-t1x9gknd 2050 6 a a DT cord-010119-t1x9gknd 2050 7 logistic logistic JJ cord-010119-t1x9gknd 2050 8 regression regression NN cord-010119-t1x9gknd 2050 9 model model NN cord-010119-t1x9gknd 2050 10 for for IN cord-010119-t1x9gknd 2050 11 TXA TXA NNP cord-010119-t1x9gknd 2050 12 use use NN cord-010119-t1x9gknd 2050 13 as as IN cord-010119-t1x9gknd 2050 14 a a DT cord-010119-t1x9gknd 2050 15 function function NN cord-010119-t1x9gknd 2050 16 of of IN cord-010119-t1x9gknd 2050 17 18 18 CD cord-010119-t1x9gknd 2050 18 baseline baseline NN cord-010119-t1x9gknd 2050 19 variable variable NN cord-010119-t1x9gknd 2050 20 , , , cord-010119-t1x9gknd 2050 21 generating generate VBG cord-010119-t1x9gknd 2050 22 969 969 CD cord-010119-t1x9gknd 2050 23 pairs pair NNS cord-010119-t1x9gknd 2050 24 of of IN cord-010119-t1x9gknd 2050 25 patients patient NNS cord-010119-t1x9gknd 2050 26 who who WP cord-010119-t1x9gknd 2050 27 received receive VBD cord-010119-t1x9gknd 2050 28 or or CC cord-010119-t1x9gknd 2050 29 did do VBD cord-010119-t1x9gknd 2050 30 not not RB cord-010119-t1x9gknd 2050 31 receive receive VB cord-010119-t1x9gknd 2050 32 TXA TXA NNP cord-010119-t1x9gknd 2050 33 . . . cord-010119-t1x9gknd 2051 1 We -PRON- PRP cord-010119-t1x9gknd 2051 2 also also RB cord-010119-t1x9gknd 2051 3 evaluated evaluate VBD cord-010119-t1x9gknd 2051 4 the the DT cord-010119-t1x9gknd 2051 5 adverse adverse JJ cord-010119-t1x9gknd 2051 6 effects effect NNS cord-010119-t1x9gknd 2051 7 of of IN cord-010119-t1x9gknd 2051 8 TXA TXA NNP cord-010119-t1x9gknd 2051 9 using use VBG cord-010119-t1x9gknd 2051 10 segmental segmental JJ cord-010119-t1x9gknd 2051 11 regression regression NN cord-010119-t1x9gknd 2051 12 analysis analysis NN cord-010119-t1x9gknd 2051 13 . . . cord-010119-t1x9gknd 2052 1 Results/ Results/ . cord-010119-t1x9gknd 2053 1 Finding finding NN cord-010119-t1x9gknd 2053 2 : : : cord-010119-t1x9gknd 2054 1 Propensity propensity NN cord-010119-t1x9gknd 2054 2 - - HYPH cord-010119-t1x9gknd 2054 3 matched match VBN cord-010119-t1x9gknd 2054 4 analysis analysis NN cord-010119-t1x9gknd 2054 5 showed show VBD cord-010119-t1x9gknd 2054 6 that that IN cord-010119-t1x9gknd 2054 7 seizures seizure NNS cord-010119-t1x9gknd 2054 8 were be VBD cord-010119-t1x9gknd 2054 9 more more RBR cord-010119-t1x9gknd 2054 10 common common JJ cord-010119-t1x9gknd 2054 11 ( ( -LRB- cord-010119-t1x9gknd 2054 12 8.7 8.7 CD cord-010119-t1x9gknd 2054 13 % % NN cord-010119-t1x9gknd 2054 14 vs vs IN cord-010119-t1x9gknd 2054 15 3.7 3.7 CD cord-010119-t1x9gknd 2054 16 % % NN cord-010119-t1x9gknd 2054 17 , , , cord-010119-t1x9gknd 2054 18 p<0.001 p<0.001 CD cord-010119-t1x9gknd 2054 19 ) ) -RRB- cord-010119-t1x9gknd 2054 20 and and CC cord-010119-t1x9gknd 2054 21 ventilation ventilation NN cord-010119-t1x9gknd 2054 22 time time NN cord-010119-t1x9gknd 2054 23 was be VBD cord-010119-t1x9gknd 2054 24 longer long JJR cord-010119-t1x9gknd 2054 25 ( ( -LRB- cord-010119-t1x9gknd 2054 26 15 15 CD cord-010119-t1x9gknd 2054 27 h h NN cord-010119-t1x9gknd 2054 28 vs vs IN cord-010119-t1x9gknd 2054 29 13 13 CD cord-010119-t1x9gknd 2054 30 h h NN cord-010119-t1x9gknd 2054 31 , , , cord-010119-t1x9gknd 2054 32 p50.04 p50.04 NNP cord-010119-t1x9gknd 2054 33 ) ) -RRB- cord-010119-t1x9gknd 2054 34 significantly significantly RB cord-010119-t1x9gknd 2054 35 in in IN cord-010119-t1x9gknd 2054 36 the the DT cord-010119-t1x9gknd 2054 37 TXA TXA NNP cord-010119-t1x9gknd 2054 38 group group NN cord-010119-t1x9gknd 2054 39 than than IN cord-010119-t1x9gknd 2054 40 in in IN cord-010119-t1x9gknd 2054 41 the the DT cord-010119-t1x9gknd 2054 42 non non JJ cord-010119-t1x9gknd 2054 43 - - JJ cord-010119-t1x9gknd 2054 44 TXA txa JJ cord-010119-t1x9gknd 2054 45 group group NN cord-010119-t1x9gknd 2054 46 . . . cord-010119-t1x9gknd 2055 1 In in IN cord-010119-t1x9gknd 2055 2 contrast contrast NN cord-010119-t1x9gknd 2055 3 , , , cord-010119-t1x9gknd 2055 4 transfusion transfusion NN cord-010119-t1x9gknd 2055 5 volume volume NN cord-010119-t1x9gknd 2055 6 and and CC cord-010119-t1x9gknd 2055 7 blood blood NN cord-010119-t1x9gknd 2055 8 loss loss NN cord-010119-t1x9gknd 2055 9 were be VBD cord-010119-t1x9gknd 2055 10 significantly significantly RB cord-010119-t1x9gknd 2055 11 lower low JJR cord-010119-t1x9gknd 2055 12 in in IN cord-010119-t1x9gknd 2055 13 the the DT cord-010119-t1x9gknd 2055 14 TXA TXA NNP cord-010119-t1x9gknd 2055 15 group group NN cord-010119-t1x9gknd 2055 16 than than IN cord-010119-t1x9gknd 2055 17 in in IN cord-010119-t1x9gknd 2055 18 the the DT cord-010119-t1x9gknd 2055 19 non non JJ cord-010119-t1x9gknd 2055 20 - - JJ cord-010119-t1x9gknd 2055 21 TXA txa JJ cord-010119-t1x9gknd 2055 22 group group NN cord-010119-t1x9gknd 2055 23 ( ( -LRB- cord-010119-t1x9gknd 2055 24 2000 2000 CD cord-010119-t1x9gknd 2055 25 ml ml NNS cord-010119-t1x9gknd 2055 26 vs vs IN cord-010119-t1x9gknd 2055 27 2200 2200 CD cord-010119-t1x9gknd 2055 28 ml ml NNS cord-010119-t1x9gknd 2055 29 , , , cord-010119-t1x9gknd 2055 30 p50.009 p50.009 NN cord-010119-t1x9gknd 2055 31 ; ; : cord-010119-t1x9gknd 2055 32 and and CC cord-010119-t1x9gknd 2055 33 1265 1265 CD cord-010119-t1x9gknd 2055 34 ml ml NNS cord-010119-t1x9gknd 2055 35 vs vs IN cord-010119-t1x9gknd 2055 36 1460 1460 CD cord-010119-t1x9gknd 2055 37 ml ml NNS cord-010119-t1x9gknd 2055 38 , , , cord-010119-t1x9gknd 2055 39 p<0.001 p<0.001 CD cord-010119-t1x9gknd 2055 40 , , , cord-010119-t1x9gknd 2055 41 respectively respectively RB cord-010119-t1x9gknd 2055 42 ) ) -RRB- cord-010119-t1x9gknd 2055 43 . . . cord-010119-t1x9gknd 2056 1 However however RB cord-010119-t1x9gknd 2056 2 , , , cord-010119-t1x9gknd 2056 3 30-day 30-day CD cord-010119-t1x9gknd 2056 4 mortality mortality NN cord-010119-t1x9gknd 2056 5 was be VBD cord-010119-t1x9gknd 2056 6 not not RB cord-010119-t1x9gknd 2056 7 statistically statistically RB cord-010119-t1x9gknd 2056 8 different different JJ cord-010119-t1x9gknd 2056 9 between between IN cord-010119-t1x9gknd 2056 10 the the DT cord-010119-t1x9gknd 2056 11 groups group NNS cord-010119-t1x9gknd 2056 12 ( ( -LRB- cord-010119-t1x9gknd 2056 13 1.6 1.6 CD cord-010119-t1x9gknd 2056 14 % % NN cord-010119-t1x9gknd 2056 15 vs vs IN cord-010119-t1x9gknd 2056 16 1.4 1.4 CD cord-010119-t1x9gknd 2056 17 % % NN cord-010119-t1x9gknd 2056 18 , , , cord-010119-t1x9gknd 2056 19 p50.82 p50.82 NN cord-010119-t1x9gknd 2056 20 ) ) -RRB- cord-010119-t1x9gknd 2056 21 . . . cord-010119-t1x9gknd 2057 1 None none NN cord-010119-t1x9gknd 2057 2 of of IN cord-010119-t1x9gknd 2057 3 the the DT cord-010119-t1x9gknd 2057 4 other other JJ cord-010119-t1x9gknd 2057 5 outcomes outcome NNS cord-010119-t1x9gknd 2057 6 were be VBD cord-010119-t1x9gknd 2057 7 significantly significantly RB cord-010119-t1x9gknd 2057 8 different different JJ cord-010119-t1x9gknd 2057 9 . . . cord-010119-t1x9gknd 2058 1 Segmental Segmental NNP cord-010119-t1x9gknd 2058 2 regression regression NN cord-010119-t1x9gknd 2058 3 analysis analysis NN cord-010119-t1x9gknd 2058 4 yielded yield VBD cord-010119-t1x9gknd 2058 5 similar similar JJ cord-010119-t1x9gknd 2058 6 results result NNS cord-010119-t1x9gknd 2058 7 . . . cord-010119-t1x9gknd 2059 1 Conclusion conclusion NN cord-010119-t1x9gknd 2059 2 : : : cord-010119-t1x9gknd 2059 3 Even even RB cord-010119-t1x9gknd 2059 4 though though IN cord-010119-t1x9gknd 2059 5 TXA TXA NNP cord-010119-t1x9gknd 2059 6 may may MD cord-010119-t1x9gknd 2059 7 be be VB cord-010119-t1x9gknd 2059 8 associated associate VBN cord-010119-t1x9gknd 2059 9 with with IN cord-010119-t1x9gknd 2059 10 an an DT cord-010119-t1x9gknd 2059 11 increased increase VBN cord-010119-t1x9gknd 2059 12 rate rate NN cord-010119-t1x9gknd 2059 13 of of IN cord-010119-t1x9gknd 2059 14 seizures seizure NNS cord-010119-t1x9gknd 2059 15 and and CC cord-010119-t1x9gknd 2059 16 longer long JJR cord-010119-t1x9gknd 2059 17 ventilator ventilator NN cord-010119-t1x9gknd 2059 18 time time NN cord-010119-t1x9gknd 2059 19 , , , cord-010119-t1x9gknd 2059 20 it -PRON- PRP cord-010119-t1x9gknd 2059 21 does do VBZ cord-010119-t1x9gknd 2059 22 not not RB cord-010119-t1x9gknd 2059 23 increase increase VB cord-010119-t1x9gknd 2059 24 mortality mortality NN cord-010119-t1x9gknd 2059 25 . . . cord-010119-t1x9gknd 2060 1 The the DT cord-010119-t1x9gknd 2060 2 use use NN cord-010119-t1x9gknd 2060 3 of of IN cord-010119-t1x9gknd 2060 4 TXA TXA NNP cord-010119-t1x9gknd 2060 5 is be VBZ cord-010119-t1x9gknd 2060 6 significantly significantly RB cord-010119-t1x9gknd 2060 7 associated associate VBN cord-010119-t1x9gknd 2060 8 with with IN cord-010119-t1x9gknd 2060 9 decreased decrease VBN cord-010119-t1x9gknd 2060 10 blood blood NN cord-010119-t1x9gknd 2060 11 loss loss NN cord-010119-t1x9gknd 2060 12 and and CC cord-010119-t1x9gknd 2060 13 transfusion transfusion NN cord-010119-t1x9gknd 2060 14 volume volume NN cord-010119-t1x9gknd 2060 15 , , , cord-010119-t1x9gknd 2060 16 providing provide VBG cord-010119-t1x9gknd 2060 17 social social JJ cord-010119-t1x9gknd 2060 18 benefit benefit NN cord-010119-t1x9gknd 2060 19 by by IN cord-010119-t1x9gknd 2060 20 reducing reduce VBG cord-010119-t1x9gknd 2060 21 the the DT cord-010119-t1x9gknd 2060 22 need need NN cord-010119-t1x9gknd 2060 23 for for IN cord-010119-t1x9gknd 2060 24 blood blood NN cord-010119-t1x9gknd 2060 25 transfusion transfusion NN cord-010119-t1x9gknd 2060 26 because because IN cord-010119-t1x9gknd 2060 27 the the DT cord-010119-t1x9gknd 2060 28 supply supply NN cord-010119-t1x9gknd 2060 29 of of IN cord-010119-t1x9gknd 2060 30 blood blood NN cord-010119-t1x9gknd 2060 31 components component NNS cord-010119-t1x9gknd 2060 32 will will MD cord-010119-t1x9gknd 2060 33 be be VB cord-010119-t1x9gknd 2060 34 limited limit VBN cord-010119-t1x9gknd 2060 35 with with IN cord-010119-t1x9gknd 2060 36 the the DT cord-010119-t1x9gknd 2060 37 aging aging NN cord-010119-t1x9gknd 2060 38 of of IN cord-010119-t1x9gknd 2060 39 Japanese japanese JJ cord-010119-t1x9gknd 2060 40 society society NN cord-010119-t1x9gknd 2060 41 . . . cord-010119-t1x9gknd 2061 1 It -PRON- PRP cord-010119-t1x9gknd 2061 2 seems seem VBZ cord-010119-t1x9gknd 2061 3 to to TO cord-010119-t1x9gknd 2061 4 be be VB cord-010119-t1x9gknd 2061 5 advantageous advantageous JJ cord-010119-t1x9gknd 2061 6 to to TO cord-010119-t1x9gknd 2061 7 use use VB cord-010119-t1x9gknd 2061 8 TXA TXA NNP cord-010119-t1x9gknd 2061 9 because because IN cord-010119-t1x9gknd 2061 10 decreased decrease VBD cord-010119-t1x9gknd 2061 11 blood blood NN cord-010119-t1x9gknd 2061 12 loss loss NN cord-010119-t1x9gknd 2061 13 and and CC cord-010119-t1x9gknd 2061 14 transfusion transfusion NN cord-010119-t1x9gknd 2061 15 volume volume NN cord-010119-t1x9gknd 2061 16 and and CC cord-010119-t1x9gknd 2061 17 the the DT cord-010119-t1x9gknd 2061 18 associated associate VBN cord-010119-t1x9gknd 2061 19 social social JJ cord-010119-t1x9gknd 2061 20 benefit benefit NN cord-010119-t1x9gknd 2061 21 outweigh outweigh VBP cord-010119-t1x9gknd 2061 22 the the DT cord-010119-t1x9gknd 2061 23 disadvantages disadvantage NNS cord-010119-t1x9gknd 2061 24 of of IN cord-010119-t1x9gknd 2061 25 an an DT cord-010119-t1x9gknd 2061 26 increased increase VBN cord-010119-t1x9gknd 2061 27 rate rate NN cord-010119-t1x9gknd 2061 28 of of IN cord-010119-t1x9gknd 2061 29 seizures seizure NNS cord-010119-t1x9gknd 2061 30 and and CC cord-010119-t1x9gknd 2061 31 longer long JJR cord-010119-t1x9gknd 2061 32 ventilator ventilator NN cord-010119-t1x9gknd 2061 33 time time NN cord-010119-t1x9gknd 2061 34 . . . cord-010119-t1x9gknd 2062 1 Sustained sustained JJ cord-010119-t1x9gknd 2062 2 Impact Impact NNP cord-010119-t1x9gknd 2062 3 of of IN cord-010119-t1x9gknd 2062 4 Blood Blood NNP cord-010119-t1x9gknd 2062 5 Management Management NNP cord-010119-t1x9gknd 2062 6 Strategies Strategies NNPS cord-010119-t1x9gknd 2062 7 in in IN cord-010119-t1x9gknd 2062 8 Orthopedics Orthopedics NNP cord-010119-t1x9gknd 2062 9 : : : cord-010119-t1x9gknd 2063 1 Continuous continuous JJ cord-010119-t1x9gknd 2063 2 Quality quality NN cord-010119-t1x9gknd 2063 3 Improvement improvement NN cord-010119-t1x9gknd 2063 4 Linda Linda NNP cord-010119-t1x9gknd 2063 5 Levinus Levinus NNP cord-010119-t1x9gknd 2063 6 * * NFP cord-010119-t1x9gknd 2063 7 and and CC cord-010119-t1x9gknd 2063 8 Michele Michele NNP cord-010119-t1x9gknd 2063 9 Deeney Deeney NNP cord-010119-t1x9gknd 2063 10 . . . cord-010119-t1x9gknd 2064 1 New New NNP cord-010119-t1x9gknd 2064 2 England England NNP cord-010119-t1x9gknd 2064 3 Baptist Baptist NNP cord-010119-t1x9gknd 2064 4 Hospital Hospital NNP cord-010119-t1x9gknd 2064 5 Background Background NNP cord-010119-t1x9gknd 2064 6 / / SYM cord-010119-t1x9gknd 2064 7 Case Case NNP cord-010119-t1x9gknd 2064 8 Studies Studies NNPS cord-010119-t1x9gknd 2065 1 : : : cord-010119-t1x9gknd 2065 2 Transfusions transfusion NNS cord-010119-t1x9gknd 2065 3 are be VBP cord-010119-t1x9gknd 2065 4 one one CD cord-010119-t1x9gknd 2065 5 of of IN cord-010119-t1x9gknd 2065 6 the the DT cord-010119-t1x9gknd 2065 7 most most RBS cord-010119-t1x9gknd 2065 8 over over RB cord-010119-t1x9gknd 2065 9 - - HYPH cord-010119-t1x9gknd 2065 10 utilized utilize VBN cord-010119-t1x9gknd 2065 11 treatments treatment NNS cord-010119-t1x9gknd 2065 12 performed perform VBN cord-010119-t1x9gknd 2065 13 in in IN cord-010119-t1x9gknd 2065 14 any any DT cord-010119-t1x9gknd 2065 15 hospital hospital NN cord-010119-t1x9gknd 2065 16 setting setting NN cord-010119-t1x9gknd 2065 17 ( ( -LRB- cord-010119-t1x9gknd 2065 18 Choosing choose VBG cord-010119-t1x9gknd 2065 19 Wisely Wisely NNP cord-010119-t1x9gknd 2065 20 Campaign Campaign NNP cord-010119-t1x9gknd 2065 21 , , , cord-010119-t1x9gknd 2065 22 April April NNP cord-010119-t1x9gknd 2065 23 2014 2014 CD cord-010119-t1x9gknd 2065 24 , , , cord-010119-t1x9gknd 2065 25 www.choosingwisely.org/societies/american-association-of-bloodbanks www.choosingwisely.org/societies/american-association-of-bloodbank NNS cord-010119-t1x9gknd 2065 26 ) ) -RRB- cord-010119-t1x9gknd 2065 27 . . . cord-010119-t1x9gknd 2066 1 Costs cost NNS cord-010119-t1x9gknd 2066 2 and and CC cord-010119-t1x9gknd 2066 3 risks risk NNS cord-010119-t1x9gknd 2066 4 associated associate VBN cord-010119-t1x9gknd 2066 5 with with IN cord-010119-t1x9gknd 2066 6 transfusions transfusion NNS cord-010119-t1x9gknd 2066 7 are be VBP cord-010119-t1x9gknd 2066 8 high high JJ cord-010119-t1x9gknd 2066 9 and and CC cord-010119-t1x9gknd 2066 10 may may MD cord-010119-t1x9gknd 2066 11 have have VB cord-010119-t1x9gknd 2066 12 a a DT cord-010119-t1x9gknd 2066 13 significant significant JJ cord-010119-t1x9gknd 2066 14 impact impact NN cord-010119-t1x9gknd 2066 15 on on IN cord-010119-t1x9gknd 2066 16 patient patient JJ cord-010119-t1x9gknd 2066 17 safety safety NN cord-010119-t1x9gknd 2066 18 . . . cord-010119-t1x9gknd 2067 1 In in IN cord-010119-t1x9gknd 2067 2 our -PRON- PRP$ cord-010119-t1x9gknd 2067 3 institution institution NN cord-010119-t1x9gknd 2067 4 we -PRON- PRP cord-010119-t1x9gknd 2067 5 perform perform VBP cord-010119-t1x9gknd 2067 6 over over IN cord-010119-t1x9gknd 2067 7 12,000 12,000 CD cord-010119-t1x9gknd 2067 8 joint joint JJ cord-010119-t1x9gknd 2067 9 replacements replacement NNS cord-010119-t1x9gknd 2067 10 and and CC cord-010119-t1x9gknd 2067 11 spine spine NN cord-010119-t1x9gknd 2067 12 surgeries surgery NNS cord-010119-t1x9gknd 2067 13 per per IN cord-010119-t1x9gknd 2067 14 year year NN cord-010119-t1x9gknd 2067 15 , , , cord-010119-t1x9gknd 2067 16 making make VBG cord-010119-t1x9gknd 2067 17 transfusion transfusion NN cord-010119-t1x9gknd 2067 18 - - HYPH cord-010119-t1x9gknd 2067 19 associated associate VBN cord-010119-t1x9gknd 2067 20 costs cost NNS cord-010119-t1x9gknd 2067 21 very very RB cord-010119-t1x9gknd 2067 22 high high JJ cord-010119-t1x9gknd 2067 23 . . . cord-010119-t1x9gknd 2068 1 Since since IN cord-010119-t1x9gknd 2068 2 our -PRON- PRP$ cord-010119-t1x9gknd 2068 3 last last JJ cord-010119-t1x9gknd 2068 4 formal formal JJ cord-010119-t1x9gknd 2068 5 evaluation evaluation NN cord-010119-t1x9gknd 2068 6 of of IN cord-010119-t1x9gknd 2068 7 the the DT cord-010119-t1x9gknd 2068 8 metrics metric NNS cord-010119-t1x9gknd 2068 9 used use VBD cord-010119-t1x9gknd 2068 10 post post NN cord-010119-t1x9gknd 2068 11 implementation implementation NN cord-010119-t1x9gknd 2068 12 of of IN cord-010119-t1x9gknd 2068 13 Patient Patient NNP cord-010119-t1x9gknd 2068 14 Blood Blood NNP cord-010119-t1x9gknd 2068 15 Management Management NNP cord-010119-t1x9gknd 2068 16 ( ( -LRB- cord-010119-t1x9gknd 2068 17 PBM PBM NNP cord-010119-t1x9gknd 2068 18 ) ) -RRB- cord-010119-t1x9gknd 2068 19 Strategies strategy NNS cord-010119-t1x9gknd 2068 20 , , , cord-010119-t1x9gknd 2068 21 questions question NNS cord-010119-t1x9gknd 2068 22 regarding regard VBG cord-010119-t1x9gknd 2068 23 the the DT cord-010119-t1x9gknd 2068 24 feasibility feasibility NN cord-010119-t1x9gknd 2068 25 of of IN cord-010119-t1x9gknd 2068 26 continued continued JJ cord-010119-t1x9gknd 2068 27 transfusion transfusion NN cord-010119-t1x9gknd 2068 28 reduction reduction NN cord-010119-t1x9gknd 2068 29 and and CC cord-010119-t1x9gknd 2068 30 sustainability sustainability NN cord-010119-t1x9gknd 2068 31 of of IN cord-010119-t1x9gknd 2068 32 the the DT cord-010119-t1x9gknd 2068 33 program program NN cord-010119-t1x9gknd 2068 34 were be VBD cord-010119-t1x9gknd 2068 35 raised raise VBN cord-010119-t1x9gknd 2068 36 by by IN cord-010119-t1x9gknd 2068 37 administration administration NN cord-010119-t1x9gknd 2068 38 and and CC cord-010119-t1x9gknd 2068 39 key key JJ cord-010119-t1x9gknd 2068 40 stakeholder stakeholder NN cord-010119-t1x9gknd 2068 41 physicians physician NNS cord-010119-t1x9gknd 2068 42 . . . cord-010119-t1x9gknd 2069 1 The the DT cord-010119-t1x9gknd 2069 2 objective objective NN cord-010119-t1x9gknd 2069 3 of of IN cord-010119-t1x9gknd 2069 4 this this DT cord-010119-t1x9gknd 2069 5 study study NN cord-010119-t1x9gknd 2069 6 is be VBZ cord-010119-t1x9gknd 2069 7 to to TO cord-010119-t1x9gknd 2069 8 determine determine VB cord-010119-t1x9gknd 2069 9 what what WP cord-010119-t1x9gknd 2069 10 , , , cord-010119-t1x9gknd 2069 11 if if IN cord-010119-t1x9gknd 2069 12 any any DT cord-010119-t1x9gknd 2069 13 , , , cord-010119-t1x9gknd 2069 14 sustainable sustainable JJ cord-010119-t1x9gknd 2069 15 improvement improvement NN cord-010119-t1x9gknd 2069 16 to to IN cord-010119-t1x9gknd 2069 17 our -PRON- PRP$ cord-010119-t1x9gknd 2069 18 blood blood NN cord-010119-t1x9gknd 2069 19 utilization utilization NN cord-010119-t1x9gknd 2069 20 dashboard dashboard NN cord-010119-t1x9gknd 2069 21 Table Table NNP cord-010119-t1x9gknd 2069 22 1 1 CD cord-010119-t1x9gknd 2069 23 ) ) -RRB- cord-010119-t1x9gknd 2069 24 . . . cord-010119-t1x9gknd 2070 1 The the DT cord-010119-t1x9gknd 2070 2 data datum NNS cord-010119-t1x9gknd 2070 3 collected collect VBD cord-010119-t1x9gknd 2070 4 show show VBP cord-010119-t1x9gknd 2070 5 that that IN cord-010119-t1x9gknd 2070 6 there there EX cord-010119-t1x9gknd 2070 7 has have VBZ cord-010119-t1x9gknd 2070 8 continued continue VBN cord-010119-t1x9gknd 2070 9 to to TO cord-010119-t1x9gknd 2070 10 be be VB cord-010119-t1x9gknd 2070 11 a a DT cord-010119-t1x9gknd 2070 12 reduction reduction NN cord-010119-t1x9gknd 2070 13 in in IN cord-010119-t1x9gknd 2070 14 transfusion transfusion NN cord-010119-t1x9gknd 2070 15 rate rate NN cord-010119-t1x9gknd 2070 16 , , , cord-010119-t1x9gknd 2070 17 and and CC cord-010119-t1x9gknd 2070 18 blood blood NN cord-010119-t1x9gknd 2070 19 expenditures expenditure NNS cord-010119-t1x9gknd 2070 20 through through IN cord-010119-t1x9gknd 2070 21 FY16 FY16 NNPS cord-010119-t1x9gknd 2070 22 . . . cord-010119-t1x9gknd 2071 1 Length length NN cord-010119-t1x9gknd 2071 2 of of IN cord-010119-t1x9gknd 2071 3 stay stay NN cord-010119-t1x9gknd 2071 4 has have VBZ cord-010119-t1x9gknd 2071 5 also also RB cord-010119-t1x9gknd 2071 6 shown show VBN cord-010119-t1x9gknd 2071 7 a a DT cord-010119-t1x9gknd 2071 8 continued continued JJ cord-010119-t1x9gknd 2071 9 reduction reduction NN cord-010119-t1x9gknd 2071 10 , , , cord-010119-t1x9gknd 2071 11 which which WDT cord-010119-t1x9gknd 2071 12 is be VBZ cord-010119-t1x9gknd 2071 13 an an DT cord-010119-t1x9gknd 2071 14 indicator indicator NN cord-010119-t1x9gknd 2071 15 that that IN cord-010119-t1x9gknd 2071 16 the the DT cord-010119-t1x9gknd 2071 17 PBM PBM NNP cord-010119-t1x9gknd 2071 18 strategies strategy NNS cord-010119-t1x9gknd 2071 19 implemented implement VBN cord-010119-t1x9gknd 2071 20 have have VBP cord-010119-t1x9gknd 2071 21 not not RB cord-010119-t1x9gknd 2071 22 compromised compromise VBN cord-010119-t1x9gknd 2071 23 quality quality NN cord-010119-t1x9gknd 2071 24 outcomes outcome NNS cord-010119-t1x9gknd 2071 25 . . . cord-010119-t1x9gknd 2072 1 Further further RB cord-010119-t1x9gknd 2072 2 , , , cord-010119-t1x9gknd 2072 3 continued continue VBD cord-010119-t1x9gknd 2072 4 review review NN cord-010119-t1x9gknd 2072 5 and and CC cord-010119-t1x9gknd 2072 6 monitoring monitoring NN cord-010119-t1x9gknd 2072 7 of of IN cord-010119-t1x9gknd 2072 8 the the DT cord-010119-t1x9gknd 2072 9 chosen choose VBN cord-010119-t1x9gknd 2072 10 metrics metric NNS cord-010119-t1x9gknd 2072 11 , , , cord-010119-t1x9gknd 2072 12 evaluating evaluate VBG cord-010119-t1x9gknd 2072 13 changes change NNS cord-010119-t1x9gknd 2072 14 to to IN cord-010119-t1x9gknd 2072 15 policy policy NN cord-010119-t1x9gknd 2072 16 and and CC cord-010119-t1x9gknd 2072 17 practice practice NN cord-010119-t1x9gknd 2072 18 related relate VBN cord-010119-t1x9gknd 2072 19 to to IN cord-010119-t1x9gknd 2072 20 transfusion transfusion NN cord-010119-t1x9gknd 2072 21 medicine medicine NN cord-010119-t1x9gknd 2072 22 , , , cord-010119-t1x9gknd 2072 23 and and CC cord-010119-t1x9gknd 2072 24 communication communication NN cord-010119-t1x9gknd 2072 25 of of IN cord-010119-t1x9gknd 2072 26 findings finding NNS cord-010119-t1x9gknd 2072 27 to to IN cord-010119-t1x9gknd 2072 28 providers provider NNS cord-010119-t1x9gknd 2072 29 / / SYM cord-010119-t1x9gknd 2072 30 administration administration NN cord-010119-t1x9gknd 2072 31 upon upon IN cord-010119-t1x9gknd 2072 32 immediate immediate JJ cord-010119-t1x9gknd 2072 33 restrospective restrospective JJ cord-010119-t1x9gknd 2072 34 analysis analysis NN cord-010119-t1x9gknd 2072 35 , , , cord-010119-t1x9gknd 2072 36 are be VBP cord-010119-t1x9gknd 2072 37 integral integral JJ cord-010119-t1x9gknd 2072 38 to to IN cord-010119-t1x9gknd 2072 39 the the DT cord-010119-t1x9gknd 2072 40 continued continue VBN cord-010119-t1x9gknd 2072 41 success success NN cord-010119-t1x9gknd 2072 42 and and CC cord-010119-t1x9gknd 2072 43 sustainability sustainability NN cord-010119-t1x9gknd 2072 44 of of IN cord-010119-t1x9gknd 2072 45 our -PRON- PRP$ cord-010119-t1x9gknd 2072 46 PBM PBM NNP cord-010119-t1x9gknd 2072 47 program program NN cord-010119-t1x9gknd 2072 48 . . . cord-010119-t1x9gknd 2073 1 Going go VBG cord-010119-t1x9gknd 2073 2 forward forward RB cord-010119-t1x9gknd 2073 3 , , , cord-010119-t1x9gknd 2073 4 these these DT cord-010119-t1x9gknd 2073 5 practices practice NNS cord-010119-t1x9gknd 2073 6 , , , cord-010119-t1x9gknd 2073 7 along along IN cord-010119-t1x9gknd 2073 8 with with IN cord-010119-t1x9gknd 2073 9 investigating investigate VBG cord-010119-t1x9gknd 2073 10 use use NN cord-010119-t1x9gknd 2073 11 of of IN cord-010119-t1x9gknd 2073 12 additional additional JJ cord-010119-t1x9gknd 2073 13 PBM PBM NNP cord-010119-t1x9gknd 2073 14 strategies strategy NNS cord-010119-t1x9gknd 2073 15 , , , cord-010119-t1x9gknd 2073 16 will will MD cord-010119-t1x9gknd 2073 17 provide provide VB cord-010119-t1x9gknd 2073 18 the the DT cord-010119-t1x9gknd 2073 19 basis basis NN cord-010119-t1x9gknd 2073 20 for for IN cord-010119-t1x9gknd 2073 21 an an DT cord-010119-t1x9gknd 2073 22 effective effective JJ cord-010119-t1x9gknd 2073 23 continuous continuous JJ cord-010119-t1x9gknd 2073 24 quality quality NN cord-010119-t1x9gknd 2073 25 improvement improvement NN cord-010119-t1x9gknd 2073 26 program program NN cord-010119-t1x9gknd 2073 27 in in IN cord-010119-t1x9gknd 2073 28 transfusion transfusion NN cord-010119-t1x9gknd 2073 29 medicine medicine NN cord-010119-t1x9gknd 2073 30 for for IN cord-010119-t1x9gknd 2073 31 orthopedics orthopedic NNS cord-010119-t1x9gknd 2073 32 . . . cord-010119-t1x9gknd 2074 1 Safety Safety NNP cord-010119-t1x9gknd 2074 2 and and CC cord-010119-t1x9gknd 2074 3 Efficacy Efficacy NNP cord-010119-t1x9gknd 2074 4 of of IN cord-010119-t1x9gknd 2074 5 4-Factor 4-Factor NNP cord-010119-t1x9gknd 2074 6 Prothrombin Prothrombin NNP cord-010119-t1x9gknd 2074 7 Complex Complex NNP cord-010119-t1x9gknd 2074 8 Concentrate Concentrate NNP cord-010119-t1x9gknd 2074 9 : : : cord-010119-t1x9gknd 2074 10 A a DT cord-010119-t1x9gknd 2074 11 Retrospective Retrospective NNP cord-010119-t1x9gknd 2074 12 Review Review NNP cord-010119-t1x9gknd 2074 13 of of IN cord-010119-t1x9gknd 2074 14 Outcomes Outcomes NNPS cord-010119-t1x9gknd 2074 15 at at IN cord-010119-t1x9gknd 2074 16 an an DT cord-010119-t1x9gknd 2074 17 Academic Academic NNP cord-010119-t1x9gknd 2074 18 Hospital Hospital NNP cord-010119-t1x9gknd 2074 19 Stephanie Stephanie NNP cord-010119-t1x9gknd 2074 20 Jalaba Jalaba NNP cord-010119-t1x9gknd 2075 1 * * NFP cord-010119-t1x9gknd 2075 2 , , , cord-010119-t1x9gknd 2075 3 Hollie Hollie NNP cord-010119-t1x9gknd 2075 4 Benson Benson NNP cord-010119-t1x9gknd 2075 5 , , , cord-010119-t1x9gknd 2075 6 Nan Nan NNP cord-010119-t1x9gknd 2075 7 Zhang Zhang NNP cord-010119-t1x9gknd 2075 8 , , , cord-010119-t1x9gknd 2075 9 Jill Jill NNP cord-010119-t1x9gknd 2075 10 Adamski Adamski NNP cord-010119-t1x9gknd 2075 11 and and CC cord-010119-t1x9gknd 2075 12 Theresa Theresa NNP cord-010119-t1x9gknd 2075 13 Kinard Kinard NNP cord-010119-t1x9gknd 2075 14 . . . cord-010119-t1x9gknd 2076 1 Mayo Mayo NNP cord-010119-t1x9gknd 2076 2 Clinic Clinic NNP cord-010119-t1x9gknd 2076 3 Arizona Arizona NNP cord-010119-t1x9gknd 2076 4 Background Background NNP cord-010119-t1x9gknd 2076 5 / / SYM cord-010119-t1x9gknd 2076 6 Case Case NNP cord-010119-t1x9gknd 2076 7 Studies Studies NNPS cord-010119-t1x9gknd 2076 8 : : : cord-010119-t1x9gknd 2076 9 4-factor 4-factor CD cord-010119-t1x9gknd 2076 10 prothrombin prothrombin NN cord-010119-t1x9gknd 2076 11 complex complex NN cord-010119-t1x9gknd 2076 12 concentrate concentrate NN cord-010119-t1x9gknd 2076 13 ( ( -LRB- cord-010119-t1x9gknd 2076 14 PCC PCC NNP cord-010119-t1x9gknd 2076 15 ) ) -RRB- cord-010119-t1x9gknd 2076 16 contains contain VBZ cord-010119-t1x9gknd 2076 17 factors factor NNS cord-010119-t1x9gknd 2076 18 II II NNP cord-010119-t1x9gknd 2076 19 , , , cord-010119-t1x9gknd 2076 20 VII VII NNP cord-010119-t1x9gknd 2076 21 , , , cord-010119-t1x9gknd 2076 22 IX IX NNP cord-010119-t1x9gknd 2076 23 , , , cord-010119-t1x9gknd 2076 24 X X NNP cord-010119-t1x9gknd 2076 25 , , , cord-010119-t1x9gknd 2076 26 Proteins Proteins NNP cord-010119-t1x9gknd 2076 27 C C NNP cord-010119-t1x9gknd 2076 28 and and CC cord-010119-t1x9gknd 2076 29 S S NNP cord-010119-t1x9gknd 2076 30 and and CC cord-010119-t1x9gknd 2076 31 is be VBZ cord-010119-t1x9gknd 2076 32 used use VBN cord-010119-t1x9gknd 2076 33 for for IN cord-010119-t1x9gknd 2076 34 reversal reversal NN cord-010119-t1x9gknd 2076 35 of of IN cord-010119-t1x9gknd 2076 36 vitamin vitamin NN cord-010119-t1x9gknd 2076 37 K K NNP cord-010119-t1x9gknd 2076 38 antagonists antagonist NNS cord-010119-t1x9gknd 2076 39 in in IN cord-010119-t1x9gknd 2076 40 acute acute JJ cord-010119-t1x9gknd 2076 41 major major JJ cord-010119-t1x9gknd 2076 42 bleeding bleeding NN cord-010119-t1x9gknd 2076 43 or or CC cord-010119-t1x9gknd 2076 44 urgent urgent JJ cord-010119-t1x9gknd 2076 45 , , , cord-010119-t1x9gknd 2076 46 invasive invasive JJ cord-010119-t1x9gknd 2076 47 procedures procedure NNS cord-010119-t1x9gknd 2076 48 . . . cord-010119-t1x9gknd 2077 1 Occasionally occasionally RB cord-010119-t1x9gknd 2077 2 , , , cord-010119-t1x9gknd 2077 3 it -PRON- PRP cord-010119-t1x9gknd 2077 4 is be VBZ cord-010119-t1x9gknd 2077 5 used use VBN cord-010119-t1x9gknd 2077 6 off off IN cord-010119-t1x9gknd 2077 7 - - HYPH cord-010119-t1x9gknd 2077 8 label label NN cord-010119-t1x9gknd 2077 9 when when WRB cord-010119-t1x9gknd 2077 10 plasma plasma NN cord-010119-t1x9gknd 2077 11 is be VBZ cord-010119-t1x9gknd 2077 12 not not RB cord-010119-t1x9gknd 2077 13 optimal optimal JJ cord-010119-t1x9gknd 2077 14 for for IN cord-010119-t1x9gknd 2077 15 achieving achieve VBG cord-010119-t1x9gknd 2077 16 hemostasis hemostasis NN cord-010119-t1x9gknd 2077 17 . . . cord-010119-t1x9gknd 2078 1 This this DT cord-010119-t1x9gknd 2078 2 study study NN cord-010119-t1x9gknd 2078 3 compares compare VBZ cord-010119-t1x9gknd 2078 4 the the DT cord-010119-t1x9gknd 2078 5 efficacy efficacy NN cord-010119-t1x9gknd 2078 6 of of IN cord-010119-t1x9gknd 2078 7 on on IN cord-010119-t1x9gknd 2078 8 - - HYPH cord-010119-t1x9gknd 2078 9 label label NN cord-010119-t1x9gknd 2078 10 and and CC cord-010119-t1x9gknd 2078 11 off off IN cord-010119-t1x9gknd 2078 12 - - HYPH cord-010119-t1x9gknd 2078 13 label label NN cord-010119-t1x9gknd 2078 14 use use NN cord-010119-t1x9gknd 2078 15 of of IN cord-010119-t1x9gknd 2078 16 PCC PCC NNP cord-010119-t1x9gknd 2078 17 in in IN cord-010119-t1x9gknd 2078 18 correcting correct VBG cord-010119-t1x9gknd 2078 19 coagulation coagulation NN cord-010119-t1x9gknd 2078 20 parameters parameter NNS cord-010119-t1x9gknd 2078 21 and and CC cord-010119-t1x9gknd 2078 22 reducing reduce VBG cord-010119-t1x9gknd 2078 23 allogeneic allogeneic NN cord-010119-t1x9gknd 2078 24 blood blood NN cord-010119-t1x9gknd 2078 25 transfusion transfusion NN cord-010119-t1x9gknd 2078 26 . . . cord-010119-t1x9gknd 2079 1 Study Study NNP cord-010119-t1x9gknd 2079 2 Design Design NNP cord-010119-t1x9gknd 2079 3 / / SYM cord-010119-t1x9gknd 2079 4 Methods method NNS cord-010119-t1x9gknd 2079 5 : : : cord-010119-t1x9gknd 2079 6 A a DT cord-010119-t1x9gknd 2079 7 retrospective retrospective JJ cord-010119-t1x9gknd 2079 8 chart chart NN cord-010119-t1x9gknd 2079 9 review review NN cord-010119-t1x9gknd 2079 10 was be VBD cord-010119-t1x9gknd 2079 11 performed perform VBN cord-010119-t1x9gknd 2079 12 for for IN cord-010119-t1x9gknd 2079 13 PCC PCC NNP cord-010119-t1x9gknd 2079 14 use use NN cord-010119-t1x9gknd 2079 15 at at IN cord-010119-t1x9gknd 2079 16 our -PRON- PRP$ cord-010119-t1x9gknd 2079 17 institution institution NN cord-010119-t1x9gknd 2079 18 in in IN cord-010119-t1x9gknd 2079 19 2015 2015 CD cord-010119-t1x9gknd 2079 20 . . . cord-010119-t1x9gknd 2080 1 Marginal marginal JJ cord-010119-t1x9gknd 2080 2 modeling modeling NN cord-010119-t1x9gknd 2080 3 ( ( -LRB- cord-010119-t1x9gknd 2080 4 GEE GEE NNP cord-010119-t1x9gknd 2080 5 method method NN cord-010119-t1x9gknd 2080 6 ) ) -RRB- cord-010119-t1x9gknd 2080 7 was be VBD cord-010119-t1x9gknd 2080 8 used use VBN cord-010119-t1x9gknd 2080 9 to to TO cord-010119-t1x9gknd 2080 10 account account VB cord-010119-t1x9gknd 2080 11 for for IN cord-010119-t1x9gknd 2080 12 within within IN cord-010119-t1x9gknd 2080 13 patient patient JJ cord-010119-t1x9gknd 2080 14 correlation correlation NN cord-010119-t1x9gknd 2080 15 and and CC cord-010119-t1x9gknd 2080 16 assess assess VB cord-010119-t1x9gknd 2080 17 changes change NNS cord-010119-t1x9gknd 2080 18 in in IN cord-010119-t1x9gknd 2080 19 lab lab NN cord-010119-t1x9gknd 2080 20 values value NNS cord-010119-t1x9gknd 2080 21 and and CC cord-010119-t1x9gknd 2080 22 products product NNS cord-010119-t1x9gknd 2080 23 transfused transfuse VBN cord-010119-t1x9gknd 2080 24 . . . cord-010119-t1x9gknd 2081 1 Logistic logistic JJ cord-010119-t1x9gknd 2081 2 regression regression NN cord-010119-t1x9gknd 2081 3 ( ( -LRB- cord-010119-t1x9gknd 2081 4 GEE GEE NNP cord-010119-t1x9gknd 2081 5 method method NN cord-010119-t1x9gknd 2081 6 ) ) -RRB- cord-010119-t1x9gknd 2081 7 was be VBD cord-010119-t1x9gknd 2081 8 used use VBN cord-010119-t1x9gknd 2081 9 to to TO cord-010119-t1x9gknd 2081 10 evaluate evaluate VB cord-010119-t1x9gknd 2081 11 potential potential JJ cord-010119-t1x9gknd 2081 12 risk risk NN cord-010119-t1x9gknd 2081 13 factors factor NNS cord-010119-t1x9gknd 2081 14 for for IN cord-010119-t1x9gknd 2081 15 unsuccessful unsuccessful JJ cord-010119-t1x9gknd 2081 16 hemostasis hemostasis NN cord-010119-t1x9gknd 2081 17 ( ( -LRB- cord-010119-t1x9gknd 2081 18 UH5 UH5 NNP cord-010119-t1x9gknd 2081 19 rate rate NN cord-010119-t1x9gknd 2081 20 of of IN cord-010119-t1x9gknd 2081 21 transfusion transfusion NN cord-010119-t1x9gknd 2081 22 after after IN cord-010119-t1x9gknd 2081 23 PCC PCC NNP cord-010119-t1x9gknd 2081 24 ! ! . cord-010119-t1x9gknd 2082 1 rate rate NN cord-010119-t1x9gknd 2082 2 before before IN cord-010119-t1x9gknd 2082 3 PCC PCC NNP cord-010119-t1x9gknd 2082 4 ) ) -RRB- cord-010119-t1x9gknd 2082 5 or or CC cord-010119-t1x9gknd 2082 6 thrombotic thrombotic JJ cord-010119-t1x9gknd 2082 7 complications complication NNS cord-010119-t1x9gknd 2082 8 . . . cord-010119-t1x9gknd 2083 1 Results result NNS cord-010119-t1x9gknd 2083 2 / / SYM cord-010119-t1x9gknd 2083 3 Findings finding NNS cord-010119-t1x9gknd 2083 4 : : : cord-010119-t1x9gknd 2084 1 The the DT cord-010119-t1x9gknd 2084 2 reduction reduction NN cord-010119-t1x9gknd 2084 3 in in IN cord-010119-t1x9gknd 2084 4 PT PT NNP cord-010119-t1x9gknd 2084 5 ( ( -LRB- cord-010119-t1x9gknd 2084 6 p5.005 p5.005 NN cord-010119-t1x9gknd 2084 7 ) ) -RRB- cord-010119-t1x9gknd 2084 8 and and CC cord-010119-t1x9gknd 2084 9 PTT PTT NNP cord-010119-t1x9gknd 2084 10 ( ( -LRB- cord-010119-t1x9gknd 2084 11 p5.05 p5.05 NNP cord-010119-t1x9gknd 2084 12 ) ) -RRB- cord-010119-t1x9gknd 2084 13 was be VBD cord-010119-t1x9gknd 2084 14 significantly significantly RB cord-010119-t1x9gknd 2084 15 greater great JJR cord-010119-t1x9gknd 2084 16 in in IN cord-010119-t1x9gknd 2084 17 on on IN cord-010119-t1x9gknd 2084 18 - - HYPH cord-010119-t1x9gknd 2084 19 label label NN cord-010119-t1x9gknd 2084 20 than than IN cord-010119-t1x9gknd 2084 21 off off IN cord-010119-t1x9gknd 2084 22 - - HYPH cord-010119-t1x9gknd 2084 23 label label NN cord-010119-t1x9gknd 2084 24 use use NN cord-010119-t1x9gknd 2084 25 . . . cord-010119-t1x9gknd 2085 1 Interestingly interestingly RB cord-010119-t1x9gknd 2085 2 , , , cord-010119-t1x9gknd 2085 3 transfusion transfusion NN cord-010119-t1x9gknd 2085 4 reduction reduction NN cord-010119-t1x9gknd 2085 5 in in IN cord-010119-t1x9gknd 2085 6 RBC RBC NNP cord-010119-t1x9gknd 2085 7 ( ( -LRB- cord-010119-t1x9gknd 2085 8 p5.03 p5.03 NNP cord-010119-t1x9gknd 2085 9 ) ) -RRB- cord-010119-t1x9gknd 2085 10 and and CC cord-010119-t1x9gknd 2085 11 plasma plasma NN cord-010119-t1x9gknd 2085 12 ( ( -LRB- cord-010119-t1x9gknd 2085 13 p5.04 p5.04 NN cord-010119-t1x9gknd 2085 14 ) ) -RRB- cord-010119-t1x9gknd 2085 15 after after IN cord-010119-t1x9gknd 2085 16 off off IN cord-010119-t1x9gknd 2085 17 - - HYPH cord-010119-t1x9gknd 2085 18 label label NN cord-010119-t1x9gknd 2085 19 use use NN cord-010119-t1x9gknd 2085 20 was be VBD cord-010119-t1x9gknd 2085 21 significantly significantly RB cord-010119-t1x9gknd 2085 22 greater great JJR cord-010119-t1x9gknd 2085 23 than than IN cord-010119-t1x9gknd 2085 24 on on IN cord-010119-t1x9gknd 2085 25 - - HYPH cord-010119-t1x9gknd 2085 26 label label NN cord-010119-t1x9gknd 2085 27 use use NN cord-010119-t1x9gknd 2085 28 . . . cord-010119-t1x9gknd 2086 1 20 20 CD cord-010119-t1x9gknd 2086 2 cases case NNS cord-010119-t1x9gknd 2086 3 , , , cord-010119-t1x9gknd 2086 4 both both CC cord-010119-t1x9gknd 2086 5 on on IN cord-010119-t1x9gknd 2086 6 - - HYPH cord-010119-t1x9gknd 2086 7 label label NN cord-010119-t1x9gknd 2086 8 and and CC cord-010119-t1x9gknd 2086 9 off off IN cord-010119-t1x9gknd 2086 10 - - HYPH cord-010119-t1x9gknd 2086 11 label label NN cord-010119-t1x9gknd 2086 12 , , , cord-010119-t1x9gknd 2086 13 with with IN cord-010119-t1x9gknd 2086 14 UH UH NNP cord-010119-t1x9gknd 2086 15 were be VBD cord-010119-t1x9gknd 2086 16 associated associate VBN cord-010119-t1x9gknd 2086 17 with with IN cord-010119-t1x9gknd 2086 18 cell cell NN cord-010119-t1x9gknd 2086 19 saver saver NN cord-010119-t1x9gknd 2086 20 , , , cord-010119-t1x9gknd 2086 21 acute acute JJ cord-010119-t1x9gknd 2086 22 normovolemic normovolemic JJ cord-010119-t1x9gknd 2086 23 hemodilution hemodilution NNP cord-010119-t1x9gknd 2086 24 ( ( -LRB- cord-010119-t1x9gknd 2086 25 ANH ANH NNP cord-010119-t1x9gknd 2086 26 ) ) -RRB- cord-010119-t1x9gknd 2086 27 , , , cord-010119-t1x9gknd 2086 28 or or CC cord-010119-t1x9gknd 2086 29 cardiopulmonary cardiopulmonary JJ cord-010119-t1x9gknd 2086 30 bypass bypass NN cord-010119-t1x9gknd 2086 31 ( ( -LRB- cord-010119-t1x9gknd 2086 32 CPB CPB NNP cord-010119-t1x9gknd 2086 33 ) ) -RRB- cord-010119-t1x9gknd 2086 34 . . . cord-010119-t1x9gknd 2087 1 The the DT cord-010119-t1x9gknd 2087 2 odds odd NNS cord-010119-t1x9gknd 2087 3 of of IN cord-010119-t1x9gknd 2087 4 having have VBG cord-010119-t1x9gknd 2087 5 UH UH NNP cord-010119-t1x9gknd 2087 6 were be VBD cord-010119-t1x9gknd 2087 7 5.5 5.5 CD cord-010119-t1x9gknd 2087 8 times time NNS cord-010119-t1x9gknd 2087 9 ( ( -LRB- cord-010119-t1x9gknd 2087 10 p5.0072 p5.0072 CD cord-010119-t1x9gknd 2087 11 ) ) -RRB- cord-010119-t1x9gknd 2087 12 more more JJR cord-010119-t1x9gknd 2087 13 with with IN cord-010119-t1x9gknd 2087 14 cell cell NN cord-010119-t1x9gknd 2087 15 saver saver NN cord-010119-t1x9gknd 2087 16 or or CC cord-010119-t1x9gknd 2087 17 ANH ANH NNP cord-010119-t1x9gknd 2087 18 , , , cord-010119-t1x9gknd 2087 19 and and CC cord-010119-t1x9gknd 2087 20 5.3 5.3 CD cord-010119-t1x9gknd 2087 21 ( ( -LRB- cord-010119-t1x9gknd 2087 22 p5.0130 p5.0130 CD cord-010119-t1x9gknd 2087 23 ) ) -RRB- cord-010119-t1x9gknd 2087 24 times time NNS cord-010119-t1x9gknd 2087 25 more more JJR cord-010119-t1x9gknd 2087 26 with with IN cord-010119-t1x9gknd 2087 27 CPB CPB NNP cord-010119-t1x9gknd 2087 28 . . . cord-010119-t1x9gknd 2088 1 Post post JJ cord-010119-t1x9gknd 2088 2 - - JJ cord-010119-t1x9gknd 2088 3 PCC PCC NNP cord-010119-t1x9gknd 2088 4 thromboses thrombose NNS cord-010119-t1x9gknd 2088 5 were be VBD cord-010119-t1x9gknd 2088 6 identified identify VBN cord-010119-t1x9gknd 2088 7 in in IN cord-010119-t1x9gknd 2088 8 6 6 CD cord-010119-t1x9gknd 2088 9 cases case NNS cord-010119-t1x9gknd 2088 10 , , , cord-010119-t1x9gknd 2088 11 but but CC cord-010119-t1x9gknd 2088 12 no no DT cord-010119-t1x9gknd 2088 13 association association NN cord-010119-t1x9gknd 2088 14 was be VBD cord-010119-t1x9gknd 2088 15 found find VBN cord-010119-t1x9gknd 2088 16 with with IN cord-010119-t1x9gknd 2088 17 potential potential JJ cord-010119-t1x9gknd 2088 18 risk risk NN cord-010119-t1x9gknd 2088 19 factors factor NNS cord-010119-t1x9gknd 2088 20 : : : cord-010119-t1x9gknd 2088 21 use use NN cord-010119-t1x9gknd 2088 22 of of IN cord-010119-t1x9gknd 2088 23 antifibrinolytics antifibrinolytic NNS cord-010119-t1x9gknd 2088 24 , , , cord-010119-t1x9gknd 2088 25 vitamin vitamin NN cord-010119-t1x9gknd 2088 26 K K NNP cord-010119-t1x9gknd 2088 27 , , , cord-010119-t1x9gknd 2088 28 Factor factor NN cord-010119-t1x9gknd 2088 29 VIIa VIIa NNS cord-010119-t1x9gknd 2088 30 , , , cord-010119-t1x9gknd 2088 31 or or CC cord-010119-t1x9gknd 2088 32 extracorporeal extracorporeal JJ cord-010119-t1x9gknd 2088 33 support support NN cord-010119-t1x9gknd 2088 34 . . . cord-010119-t1x9gknd 2088 35 _SP cord-010119-t1x9gknd 2089 1 Background Background NNP cord-010119-t1x9gknd 2089 2 / / SYM cord-010119-t1x9gknd 2089 3 Case Case NNP cord-010119-t1x9gknd 2089 4 Studies Studies NNPS cord-010119-t1x9gknd 2089 5 : : : cord-010119-t1x9gknd 2090 1 When when WRB cord-010119-t1x9gknd 2090 2 a a DT cord-010119-t1x9gknd 2090 3 pregnant pregnant JJ cord-010119-t1x9gknd 2090 4 woman woman NN cord-010119-t1x9gknd 2090 5 with with IN cord-010119-t1x9gknd 2090 6 high high JJ cord-010119-t1x9gknd 2090 7 risk risk NN cord-010119-t1x9gknd 2090 8 pregnancy pregnancy NN cord-010119-t1x9gknd 2090 9 ( ( -LRB- cord-010119-t1x9gknd 2090 10 diagnoses diagnosis NNS cord-010119-t1x9gknd 2090 11 such such JJ cord-010119-t1x9gknd 2090 12 as as IN cord-010119-t1x9gknd 2090 13 abnormal abnormal JJ cord-010119-t1x9gknd 2090 14 placentation placentation NN cord-010119-t1x9gknd 2090 15 , , , cord-010119-t1x9gknd 2090 16 multiple multiple JJ cord-010119-t1x9gknd 2090 17 gestation gestation NN cord-010119-t1x9gknd 2090 18 ) ) -RRB- cord-010119-t1x9gknd 2090 19 is be VBZ cord-010119-t1x9gknd 2090 20 admitted admit VBN cord-010119-t1x9gknd 2090 21 to to IN cord-010119-t1x9gknd 2090 22 inpatient inpatient JJ cord-010119-t1x9gknd 2090 23 bedrest bedrest RB cord-010119-t1x9gknd 2090 24 the the DT cord-010119-t1x9gknd 2090 25 obstetrical obstetrical JJ cord-010119-t1x9gknd 2090 26 team team NN cord-010119-t1x9gknd 2090 27 would would MD cord-010119-t1x9gknd 2090 28 like like VB cord-010119-t1x9gknd 2090 29 to to TO cord-010119-t1x9gknd 2090 30 assure assure VB cord-010119-t1x9gknd 2090 31 ability ability NN cord-010119-t1x9gknd 2090 32 to to TO cord-010119-t1x9gknd 2090 33 crossmatch crossmatch VB cord-010119-t1x9gknd 2090 34 red red JJ cord-010119-t1x9gknd 2090 35 blood blood NN cord-010119-t1x9gknd 2090 36 cells cell NNS cord-010119-t1x9gknd 2090 37 ( ( -LRB- cord-010119-t1x9gknd 2090 38 RBC RBC NNP cord-010119-t1x9gknd 2090 39 ) ) -RRB- cord-010119-t1x9gknd 2090 40 at at IN cord-010119-t1x9gknd 2090 41 all all DT cord-010119-t1x9gknd 2090 42 times time NNS cord-010119-t1x9gknd 2090 43 by by IN cord-010119-t1x9gknd 2090 44 always always RB cord-010119-t1x9gknd 2090 45 having have VBG cord-010119-t1x9gknd 2090 46 an an DT cord-010119-t1x9gknd 2090 47 in in IN cord-010119-t1x9gknd 2090 48 - - HYPH cord-010119-t1x9gknd 2090 49 date date NN cord-010119-t1x9gknd 2090 50 type type NN cord-010119-t1x9gknd 2090 51 and and CC cord-010119-t1x9gknd 2090 52 screen screen NN cord-010119-t1x9gknd 2090 53 specimen specimen NN cord-010119-t1x9gknd 2090 54 . . . cord-010119-t1x9gknd 2091 1 Per per IN cord-010119-t1x9gknd 2091 2 current current JJ cord-010119-t1x9gknd 2091 3 AABB AABB NNP cord-010119-t1x9gknd 2091 4 Standards Standards NNPS cord-010119-t1x9gknd 2091 5 , , , cord-010119-t1x9gknd 2091 6 this this DT cord-010119-t1x9gknd 2091 7 necessitates necessitate VBZ cord-010119-t1x9gknd 2091 8 a a DT cord-010119-t1x9gknd 2091 9 new new JJ cord-010119-t1x9gknd 2091 10 sample sample NN cord-010119-t1x9gknd 2091 11 every every DT cord-010119-t1x9gknd 2091 12 3 3 CD cord-010119-t1x9gknd 2091 13 days day NNS cord-010119-t1x9gknd 2091 14 . . . cord-010119-t1x9gknd 2092 1 This this DT cord-010119-t1x9gknd 2092 2 can can MD cord-010119-t1x9gknd 2092 3 lead lead VB cord-010119-t1x9gknd 2092 4 to to IN cord-010119-t1x9gknd 2092 5 excessive excessive JJ cord-010119-t1x9gknd 2092 6 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 2092 7 blood blood NN cord-010119-t1x9gknd 2092 8 loss loss NN cord-010119-t1x9gknd 2092 9 and and CC cord-010119-t1x9gknd 2092 10 increasing increase VBG cord-010119-t1x9gknd 2092 11 difficulty difficulty NN cord-010119-t1x9gknd 2092 12 with with IN cord-010119-t1x9gknd 2092 13 obtaining obtain VBG cord-010119-t1x9gknd 2092 14 intravenous intravenous JJ cord-010119-t1x9gknd 2092 15 access access NN cord-010119-t1x9gknd 2092 16 in in IN cord-010119-t1x9gknd 2092 17 the the DT cord-010119-t1x9gknd 2092 18 patient patient NN cord-010119-t1x9gknd 2092 19 , , , cord-010119-t1x9gknd 2092 20 to to IN cord-010119-t1x9gknd 2092 21 the the DT cord-010119-t1x9gknd 2092 22 point point NN cord-010119-t1x9gknd 2092 23 that that IN cord-010119-t1x9gknd 2092 24 an an DT cord-010119-t1x9gknd 2092 25 invasive invasive JJ cord-010119-t1x9gknd 2092 26 catheter catheter NN cord-010119-t1x9gknd 2092 27 such such JJ cord-010119-t1x9gknd 2092 28 as as IN cord-010119-t1x9gknd 2092 29 a a DT cord-010119-t1x9gknd 2092 30 PICC PICC NNP cord-010119-t1x9gknd 2092 31 line line NN cord-010119-t1x9gknd 2092 32 may may MD cord-010119-t1x9gknd 2092 33 be be VB cord-010119-t1x9gknd 2092 34 placed place VBN cord-010119-t1x9gknd 2092 35 . . . cord-010119-t1x9gknd 2093 1 In in IN cord-010119-t1x9gknd 2093 2 order order NN cord-010119-t1x9gknd 2093 3 to to TO cord-010119-t1x9gknd 2093 4 mitigate mitigate VB cord-010119-t1x9gknd 2093 5 these these DT cord-010119-t1x9gknd 2093 6 issues issue NNS cord-010119-t1x9gknd 2093 7 , , , cord-010119-t1x9gknd 2093 8 we -PRON- PRP cord-010119-t1x9gknd 2093 9 chose choose VBD cord-010119-t1x9gknd 2093 10 to to TO cord-010119-t1x9gknd 2093 11 extend extend VB cord-010119-t1x9gknd 2093 12 the the DT cord-010119-t1x9gknd 2093 13 type type NN cord-010119-t1x9gknd 2093 14 and and CC cord-010119-t1x9gknd 2093 15 screen screen NN cord-010119-t1x9gknd 2093 16 specimen specimen NN cord-010119-t1x9gknd 2093 17 to to TO cord-010119-t1x9gknd 2093 18 expire expire VB cord-010119-t1x9gknd 2093 19 after after IN cord-010119-t1x9gknd 2093 20 7 7 CD cord-010119-t1x9gknd 2093 21 days day NNS cord-010119-t1x9gknd 2093 22 in in IN cord-010119-t1x9gknd 2093 23 patients patient NNS cord-010119-t1x9gknd 2093 24 without without IN cord-010119-t1x9gknd 2093 25 RBC RBC NNP cord-010119-t1x9gknd 2093 26 alloantibodies alloantibody NNS cord-010119-t1x9gknd 2093 27 other other JJ cord-010119-t1x9gknd 2093 28 than than IN cord-010119-t1x9gknd 2093 29 passively passively RB cord-010119-t1x9gknd 2093 30 acquired acquire VBN cord-010119-t1x9gknd 2093 31 anti anti JJ cord-010119-t1x9gknd 2093 32 - - JJ cord-010119-t1x9gknd 2093 33 D d JJ cord-010119-t1x9gknd 2093 34 due due IN cord-010119-t1x9gknd 2093 35 to to IN cord-010119-t1x9gknd 2093 36 Rh Rh NNP cord-010119-t1x9gknd 2093 37 immune immune JJ cord-010119-t1x9gknd 2093 38 globulin globulin NN cord-010119-t1x9gknd 2093 39 administration administration NN cord-010119-t1x9gknd 2093 40 . . . cord-010119-t1x9gknd 2094 1 Study Study NNP cord-010119-t1x9gknd 2094 2 Design Design NNP cord-010119-t1x9gknd 2094 3 / / SYM cord-010119-t1x9gknd 2094 4 Method method NN cord-010119-t1x9gknd 2094 5 : : : cord-010119-t1x9gknd 2095 1 Patients patient NNS cord-010119-t1x9gknd 2095 2 expected expect VBN cord-010119-t1x9gknd 2095 3 to to TO cord-010119-t1x9gknd 2095 4 have have VB cord-010119-t1x9gknd 2095 5 an an DT cord-010119-t1x9gknd 2095 6 antenatal antenatal JJ cord-010119-t1x9gknd 2095 7 hospitalization hospitalization NN cord-010119-t1x9gknd 2095 8 of of IN cord-010119-t1x9gknd 2095 9 at at RB cord-010119-t1x9gknd 2095 10 least least JJS cord-010119-t1x9gknd 2095 11 4 4 CD cord-010119-t1x9gknd 2095 12 days day NNS cord-010119-t1x9gknd 2095 13 with with IN cord-010119-t1x9gknd 2095 14 high high JJ cord-010119-t1x9gknd 2095 15 risk risk NN cord-010119-t1x9gknd 2095 16 for for IN cord-010119-t1x9gknd 2095 17 transfusion transfusion NN cord-010119-t1x9gknd 2095 18 need need NN cord-010119-t1x9gknd 2095 19 are be VBP cord-010119-t1x9gknd 2095 20 identified identify VBN cord-010119-t1x9gknd 2095 21 by by IN cord-010119-t1x9gknd 2095 22 the the DT cord-010119-t1x9gknd 2095 23 obstetrical obstetrical JJ cord-010119-t1x9gknd 2095 24 service service NN cord-010119-t1x9gknd 2095 25 , , , cord-010119-t1x9gknd 2095 26 which which WDT cord-010119-t1x9gknd 2095 27 submits submit VBZ cord-010119-t1x9gknd 2095 28 a a DT cord-010119-t1x9gknd 2095 29 request request NN cord-010119-t1x9gknd 2095 30 to to IN cord-010119-t1x9gknd 2095 31 the the DT cord-010119-t1x9gknd 2095 32 transfusion transfusion NN cord-010119-t1x9gknd 2095 33 service service NN cord-010119-t1x9gknd 2095 34 for for IN cord-010119-t1x9gknd 2095 35 extension extension NN cord-010119-t1x9gknd 2095 36 of of IN cord-010119-t1x9gknd 2095 37 pre pre JJ cord-010119-t1x9gknd 2095 38 - - JJ cord-010119-t1x9gknd 2095 39 transfusion transfusion JJ cord-010119-t1x9gknd 2095 40 specimens specimen NNS cord-010119-t1x9gknd 2095 41 to to IN cord-010119-t1x9gknd 2095 42 7 7 CD cord-010119-t1x9gknd 2095 43 days day NNS cord-010119-t1x9gknd 2095 44 . . . cord-010119-t1x9gknd 2096 1 The the DT cord-010119-t1x9gknd 2096 2 transfusion transfusion NN cord-010119-t1x9gknd 2096 3 service service NN cord-010119-t1x9gknd 2096 4 medical medical JJ cord-010119-t1x9gknd 2096 5 director director NN cord-010119-t1x9gknd 2096 6 reviews review VBZ cord-010119-t1x9gknd 2096 7 the the DT cord-010119-t1x9gknd 2096 8 case case NN cord-010119-t1x9gknd 2096 9 and and CC cord-010119-t1x9gknd 2096 10 gives give VBZ cord-010119-t1x9gknd 2096 11 final final JJ cord-010119-t1x9gknd 2096 12 approval approval NN cord-010119-t1x9gknd 2096 13 . . . cord-010119-t1x9gknd 2097 1 We -PRON- PRP cord-010119-t1x9gknd 2097 2 observed observe VBD cord-010119-t1x9gknd 2097 3 Only only RB cord-010119-t1x9gknd 2097 4 1 1 CD cord-010119-t1x9gknd 2097 5 patient patient NN cord-010119-t1x9gknd 2097 6 did do VBD cord-010119-t1x9gknd 2097 7 not not RB cord-010119-t1x9gknd 2097 8 have have VB cord-010119-t1x9gknd 2097 9 an an DT cord-010119-t1x9gknd 2097 10 in in IN cord-010119-t1x9gknd 2097 11 - - HYPH cord-010119-t1x9gknd 2097 12 date date NN cord-010119-t1x9gknd 2097 13 specimen specimen NN cord-010119-t1x9gknd 2097 14 when when WRB cord-010119-t1x9gknd 2097 15 the the DT cord-010119-t1x9gknd 2097 16 extended extend VBN cord-010119-t1x9gknd 2097 17 out out NN cord-010119-t1x9gknd 2097 18 - - HYPH cord-010119-t1x9gknd 2097 19 dating dating NN cord-010119-t1x9gknd 2097 20 was be VBD cord-010119-t1x9gknd 2097 21 requested request VBN cord-010119-t1x9gknd 2097 22 . . . cord-010119-t1x9gknd 2098 1 Thirty thirty CD cord-010119-t1x9gknd 2098 2 - - HYPH cord-010119-t1x9gknd 2098 3 eight eight CD cord-010119-t1x9gknd 2098 4 ( ( -LRB- cord-010119-t1x9gknd 2098 5 38 38 CD cord-010119-t1x9gknd 2098 6 ) ) -RRB- cord-010119-t1x9gknd 2098 7 patients patient NNS cord-010119-t1x9gknd 2098 8 were be VBD cord-010119-t1x9gknd 2098 9 in in IN cord-010119-t1x9gknd 2098 10 - - HYPH cord-010119-t1x9gknd 2098 11 patients patient NNS cord-010119-t1x9gknd 2098 12 continuously continuously RB cord-010119-t1x9gknd 2098 13 until until IN cord-010119-t1x9gknd 2098 14 delivery delivery NN cord-010119-t1x9gknd 2098 15 . . . cord-010119-t1x9gknd 2099 1 Five five CD cord-010119-t1x9gknd 2099 2 patients patient NNS cord-010119-t1x9gknd 2099 3 were be VBD cord-010119-t1x9gknd 2099 4 discharged discharge VBN cord-010119-t1x9gknd 2099 5 prior prior RB cord-010119-t1x9gknd 2099 6 to to IN cord-010119-t1x9gknd 2099 7 delivery-1 delivery-1 NNP cord-010119-t1x9gknd 2099 8 moved move VBD cord-010119-t1x9gknd 2099 9 to to IN cord-010119-t1x9gknd 2099 10 another another DT cord-010119-t1x9gknd 2099 11 state state NN cord-010119-t1x9gknd 2099 12 , , , cord-010119-t1x9gknd 2099 13 1 1 CD cord-010119-t1x9gknd 2099 14 was be VBD cord-010119-t1x9gknd 2099 15 admitted admit VBN cord-010119-t1x9gknd 2099 16 later later RB cord-010119-t1x9gknd 2099 17 at at IN cord-010119-t1x9gknd 2099 18 another another DT cord-010119-t1x9gknd 2099 19 local local JJ cord-010119-t1x9gknd 2099 20 hospital hospital NN cord-010119-t1x9gknd 2099 21 , , , cord-010119-t1x9gknd 2099 22 and and CC cord-010119-t1x9gknd 2099 23 three three CD cord-010119-t1x9gknd 2099 24 were be VBD cord-010119-t1x9gknd 2099 25 readmitted readmitte VBN cord-010119-t1x9gknd 2099 26 for for IN cord-010119-t1x9gknd 2099 27 later later JJ cord-010119-t1x9gknd 2099 28 deliveries delivery NNS cord-010119-t1x9gknd 2099 29 . . . cord-010119-t1x9gknd 2100 1 The the DT cord-010119-t1x9gknd 2100 2 mean mean JJ cord-010119-t1x9gknd 2100 3 interval interval NN cord-010119-t1x9gknd 2100 4 from from IN cord-010119-t1x9gknd 2100 5 approval approval NN cord-010119-t1x9gknd 2100 6 to to IN cord-010119-t1x9gknd 2100 7 delivery delivery NN cord-010119-t1x9gknd 2100 8 was be VBD cord-010119-t1x9gknd 2100 9 17 17 CD cord-010119-t1x9gknd 2100 10 days day NNS cord-010119-t1x9gknd 2101 1 ( ( -LRB- cord-010119-t1x9gknd 2101 2 range range NN cord-010119-t1x9gknd 2101 3 0 0 CD cord-010119-t1x9gknd 2101 4 - - SYM cord-010119-t1x9gknd 2101 5 63 63 CD cord-010119-t1x9gknd 2101 6 ) ) -RRB- cord-010119-t1x9gknd 2101 7 . . . cord-010119-t1x9gknd 2102 1 Six six CD cord-010119-t1x9gknd 2102 2 ( ( -LRB- cord-010119-t1x9gknd 2102 3 6 6 CD cord-010119-t1x9gknd 2102 4 ) ) -RRB- cord-010119-t1x9gknd 2102 5 patients patient NNS cord-010119-t1x9gknd 2102 6 delivered deliver VBD cord-010119-t1x9gknd 2102 7 within within IN cord-010119-t1x9gknd 2102 8 3 3 CD cord-010119-t1x9gknd 2102 9 days day NNS cord-010119-t1x9gknd 2102 10 of of IN cord-010119-t1x9gknd 2102 11 approval approval NN cord-010119-t1x9gknd 2102 12 . . . cord-010119-t1x9gknd 2103 1 After after IN cord-010119-t1x9gknd 2103 2 approval approval NN cord-010119-t1x9gknd 2103 3 , , , cord-010119-t1x9gknd 2103 4 the the DT cord-010119-t1x9gknd 2103 5 mean mean JJ cord-010119-t1x9gknd 2103 6 number number NN cord-010119-t1x9gknd 2103 7 of of IN cord-010119-t1x9gknd 2103 8 additional additional JJ cord-010119-t1x9gknd 2103 9 specimens specimen NNS cord-010119-t1x9gknd 2103 10 per per IN cord-010119-t1x9gknd 2103 11 patient patient NN cord-010119-t1x9gknd 2103 12 was be VBD cord-010119-t1x9gknd 2103 13 2.1 2.1 CD cord-010119-t1x9gknd 2103 14 ( ( -LRB- cord-010119-t1x9gknd 2103 15 range range NN cord-010119-t1x9gknd 2103 16 , , , cord-010119-t1x9gknd 2103 17 0 0 CD cord-010119-t1x9gknd 2103 18 - - SYM cord-010119-t1x9gknd 2103 19 9 9 CD cord-010119-t1x9gknd 2103 20 ) ) -RRB- cord-010119-t1x9gknd 2103 21 . . . cord-010119-t1x9gknd 2104 1 No no DT cord-010119-t1x9gknd 2104 2 patient patient NN cord-010119-t1x9gknd 2104 3 required require VBN cord-010119-t1x9gknd 2104 4 transfusion transfusion NN cord-010119-t1x9gknd 2104 5 prior prior RB cord-010119-t1x9gknd 2104 6 to to IN cord-010119-t1x9gknd 2104 7 delivery delivery NN cord-010119-t1x9gknd 2104 8 . . . cord-010119-t1x9gknd 2105 1 Five five CD cord-010119-t1x9gknd 2105 2 patients patient NNS cord-010119-t1x9gknd 2105 3 received receive VBD cord-010119-t1x9gknd 2105 4 transfusion transfusion NN cord-010119-t1x9gknd 2105 5 of of IN cord-010119-t1x9gknd 2105 6 at at RB cord-010119-t1x9gknd 2105 7 least least JJS cord-010119-t1x9gknd 2105 8 1 1 CD cord-010119-t1x9gknd 2105 9 RBC RBC NNP cord-010119-t1x9gknd 2105 10 at at IN cord-010119-t1x9gknd 2105 11 the the DT cord-010119-t1x9gknd 2105 12 time time NN cord-010119-t1x9gknd 2105 13 of of IN cord-010119-t1x9gknd 2105 14 delivery delivery NN cord-010119-t1x9gknd 2105 15 , , , cord-010119-t1x9gknd 2105 16 and and CC cord-010119-t1x9gknd 2105 17 none none NN cord-010119-t1x9gknd 2105 18 had have VBD cord-010119-t1x9gknd 2105 19 evidence evidence NN cord-010119-t1x9gknd 2105 20 of of IN cord-010119-t1x9gknd 2105 21 transfusion transfusion NN cord-010119-t1x9gknd 2105 22 reaction reaction NN cord-010119-t1x9gknd 2105 23 . . . cord-010119-t1x9gknd 2106 1 Conclusion conclusion NN cord-010119-t1x9gknd 2106 2 : : : cord-010119-t1x9gknd 2107 1 Since since IN cord-010119-t1x9gknd 2107 2 no no DT cord-010119-t1x9gknd 2107 3 new new JJ cord-010119-t1x9gknd 2107 4 antibodies antibody NNS cord-010119-t1x9gknd 2107 5 were be VBD cord-010119-t1x9gknd 2107 6 identified identify VBN cord-010119-t1x9gknd 2107 7 prior prior RB cord-010119-t1x9gknd 2107 8 to to IN cord-010119-t1x9gknd 2107 9 discharge discharge NN cord-010119-t1x9gknd 2107 10 or or CC cord-010119-t1x9gknd 2107 11 delivery delivery NN cord-010119-t1x9gknd 2107 12 and and CC cord-010119-t1x9gknd 2107 13 no no DT cord-010119-t1x9gknd 2107 14 transfusion transfusion NN cord-010119-t1x9gknd 2107 15 reactions reaction NNS cord-010119-t1x9gknd 2107 16 were be VBD cord-010119-t1x9gknd 2107 17 observed observe VBN cord-010119-t1x9gknd 2107 18 , , , cord-010119-t1x9gknd 2107 19 the the DT cord-010119-t1x9gknd 2107 20 process process NN cord-010119-t1x9gknd 2107 21 appears appear VBZ cord-010119-t1x9gknd 2107 22 safe safe JJ cord-010119-t1x9gknd 2107 23 . . . cord-010119-t1x9gknd 2108 1 With with IN cord-010119-t1x9gknd 2108 2 only only RB cord-010119-t1x9gknd 2108 3 6 6 CD cord-010119-t1x9gknd 2108 4 patients patient NNS cord-010119-t1x9gknd 2108 5 delivering deliver VBG cord-010119-t1x9gknd 2108 6 within within IN cord-010119-t1x9gknd 2108 7 3 3 CD cord-010119-t1x9gknd 2108 8 days day NNS cord-010119-t1x9gknd 2108 9 of of IN cord-010119-t1x9gknd 2108 10 approval approval NN cord-010119-t1x9gknd 2108 11 for for IN cord-010119-t1x9gknd 2108 12 extended extended JJ cord-010119-t1x9gknd 2108 13 specimens specimen NNS cord-010119-t1x9gknd 2108 14 , , , cord-010119-t1x9gknd 2108 15 37 37 CD cord-010119-t1x9gknd 2108 16 patients patient NNS cord-010119-t1x9gknd 2108 17 avoided avoid VBD cord-010119-t1x9gknd 2108 18 collection collection NN cord-010119-t1x9gknd 2108 19 of of IN cord-010119-t1x9gknd 2108 20 at at RB cord-010119-t1x9gknd 2108 21 least least JJS cord-010119-t1x9gknd 2108 22 1 1 CD cord-010119-t1x9gknd 2108 23 specimen specimen NN cord-010119-t1x9gknd 2108 24 each each DT cord-010119-t1x9gknd 2108 25 , , , cord-010119-t1x9gknd 2108 26 and and CC cord-010119-t1x9gknd 2108 27 16 16 CD cord-010119-t1x9gknd 2108 28 patients patient NNS cord-010119-t1x9gknd 2108 29 avoided avoid VBD cord-010119-t1x9gknd 2108 30 at at IN cord-010119-t1x9gknd 2108 31 least least JJS cord-010119-t1x9gknd 2108 32 4 4 CD cord-010119-t1x9gknd 2108 33 collections collection NNS cord-010119-t1x9gknd 2108 34 each each DT cord-010119-t1x9gknd 2108 35 . . . cord-010119-t1x9gknd 2109 1 Since since IN cord-010119-t1x9gknd 2109 2 new new JJ cord-010119-t1x9gknd 2109 3 antibodies antibody NNS cord-010119-t1x9gknd 2109 4 are be VBP cord-010119-t1x9gknd 2109 5 not not RB cord-010119-t1x9gknd 2109 6 detectable detectable JJ cord-010119-t1x9gknd 2109 7 for for IN cord-010119-t1x9gknd 2109 8 at at RB cord-010119-t1x9gknd 2109 9 least least RBS cord-010119-t1x9gknd 2109 10 10 10 CD cord-010119-t1x9gknd 2109 11 days day NNS cord-010119-t1x9gknd 2109 12 after after IN cord-010119-t1x9gknd 2109 13 immunization immunization NN cord-010119-t1x9gknd 2109 14 , , , cord-010119-t1x9gknd 2109 15 even even RB cord-010119-t1x9gknd 2109 16 longer long JJR cord-010119-t1x9gknd 2109 17 extension extension NN cord-010119-t1x9gknd 2109 18 of of IN cord-010119-t1x9gknd 2109 19 pre pre JJ cord-010119-t1x9gknd 2109 20 - - JJ cord-010119-t1x9gknd 2109 21 transfusion transfusion JJ cord-010119-t1x9gknd 2109 22 specimen specimen NN cord-010119-t1x9gknd 2109 23 out out IN cord-010119-t1x9gknd 2109 24 - - HYPH cord-010119-t1x9gknd 2109 25 date date NN cord-010119-t1x9gknd 2109 26 may may MD cord-010119-t1x9gknd 2109 27 be be VB cord-010119-t1x9gknd 2109 28 considered consider VBN cord-010119-t1x9gknd 2109 29 . . . cord-010119-t1x9gknd 2110 1 Although although IN cord-010119-t1x9gknd 2110 2 this this DT cord-010119-t1x9gknd 2110 3 requires require VBZ cord-010119-t1x9gknd 2110 4 further further JJ cord-010119-t1x9gknd 2110 5 study study NN cord-010119-t1x9gknd 2110 6 , , , cord-010119-t1x9gknd 2110 7 we -PRON- PRP cord-010119-t1x9gknd 2110 8 believe believe VBP cord-010119-t1x9gknd 2110 9 our -PRON- PRP$ cord-010119-t1x9gknd 2110 10 practice practice NN cord-010119-t1x9gknd 2110 11 of of IN cord-010119-t1x9gknd 2110 12 extending extend VBG cord-010119-t1x9gknd 2110 13 the the DT cord-010119-t1x9gknd 2110 14 pre pre JJ cord-010119-t1x9gknd 2110 15 - - JJ cord-010119-t1x9gknd 2110 16 transfusion transfusion JJ cord-010119-t1x9gknd 2110 17 testing testing NN cord-010119-t1x9gknd 2110 18 sample sample NN cord-010119-t1x9gknd 2110 19 expiration expiration NN cord-010119-t1x9gknd 2110 20 date date NN cord-010119-t1x9gknd 2110 21 to to IN cord-010119-t1x9gknd 2110 22 7 7 CD cord-010119-t1x9gknd 2110 23 days day NNS cord-010119-t1x9gknd 2110 24 is be VBZ cord-010119-t1x9gknd 2110 25 safe safe JJ cord-010119-t1x9gknd 2110 26 and and CC cord-010119-t1x9gknd 2110 27 is be VBZ cord-010119-t1x9gknd 2110 28 justified justify VBN cord-010119-t1x9gknd 2110 29 , , , cord-010119-t1x9gknd 2110 30 when when WRB cord-010119-t1x9gknd 2110 31 weighed weigh VBN cord-010119-t1x9gknd 2110 32 against against IN cord-010119-t1x9gknd 2110 33 the the DT cord-010119-t1x9gknd 2110 34 risk risk NN cord-010119-t1x9gknd 2110 35 of of IN cord-010119-t1x9gknd 2110 36 excess excess JJ cord-010119-t1x9gknd 2110 37 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 2110 38 blood blood NN cord-010119-t1x9gknd 2110 39 loss loss NN cord-010119-t1x9gknd 2110 40 and and CC cord-010119-t1x9gknd 2110 41 placing place VBG cord-010119-t1x9gknd 2110 42 an an DT cord-010119-t1x9gknd 2110 43 invasive invasive JJ cord-010119-t1x9gknd 2110 44 line line NN cord-010119-t1x9gknd 2110 45 for for IN cord-010119-t1x9gknd 2110 46 blood blood NN cord-010119-t1x9gknd 2110 47 sampling sampling NN cord-010119-t1x9gknd 2110 48 in in IN cord-010119-t1x9gknd 2110 49 a a DT cord-010119-t1x9gknd 2110 50 pregnant pregnant JJ cord-010119-t1x9gknd 2110 51 patient patient NN cord-010119-t1x9gknd 2110 52 . . . cord-010119-t1x9gknd 2111 1 Iron iron NN cord-010119-t1x9gknd 2111 2 Metabolism metabolism NN cord-010119-t1x9gknd 2111 3 in in IN cord-010119-t1x9gknd 2111 4 Critically Critically NNP cord-010119-t1x9gknd 2111 5 Ill Ill NNP cord-010119-t1x9gknd 2111 6 Patients patient NNS cord-010119-t1x9gknd 2111 7 Developing develop VBG cord-010119-t1x9gknd 2111 8 Anemia anemia NN cord-010119-t1x9gknd 2111 9 of of IN cord-010119-t1x9gknd 2111 10 Inflammation inflammation NN cord-010119-t1x9gknd 2111 11 Margit Margit NNP cord-010119-t1x9gknd 2111 12 Boshuizen Boshuizen NNP cord-010119-t1x9gknd 2112 1 * * NFP cord-010119-t1x9gknd 2112 2 1,2 1,2 CD cord-010119-t1x9gknd 2112 3 , , , cord-010119-t1x9gknd 2112 4 Jan Jan NNP cord-010119-t1x9gknd 2112 5 M. M. NNP cord-010119-t1x9gknd 2112 6 Binnekade Binnekade NNP cord-010119-t1x9gknd 2112 7 1 1 CD cord-010119-t1x9gknd 2112 8 , , , cord-010119-t1x9gknd 2112 9 Benjamin Benjamin NNP cord-010119-t1x9gknd 2112 10 Nota Nota NNP cord-010119-t1x9gknd 2112 11 2 2 CD cord-010119-t1x9gknd 2112 12 , , , cord-010119-t1x9gknd 2112 13 Pieter Pieter NNP cord-010119-t1x9gknd 2112 14 R R NNP cord-010119-t1x9gknd 2112 15 Tuinman Tuinman NNP cord-010119-t1x9gknd 2112 16 3 3 CD cord-010119-t1x9gknd 2112 17 , , , cord-010119-t1x9gknd 2112 18 Kirsten Kirsten NNP cord-010119-t1x9gknd 2112 19 van van NNP cord-010119-t1x9gknd 2112 20 de de NNP cord-010119-t1x9gknd 2112 21 Groep Groep NNP cord-010119-t1x9gknd 2112 22 4 4 CD cord-010119-t1x9gknd 2112 23 , , , cord-010119-t1x9gknd 2112 24 Olaf Olaf NNP cord-010119-t1x9gknd 2112 25 L L NNP cord-010119-t1x9gknd 2112 26 Cremer Cremer NNP cord-010119-t1x9gknd 2112 27 4 4 CD cord-010119-t1x9gknd 2112 28 , , , cord-010119-t1x9gknd 2112 29 Janneke Janneke NNP cord-010119-t1x9gknd 2112 30 Horn Horn NNP cord-010119-t1x9gknd 2112 31 1 1 CD cord-010119-t1x9gknd 2112 32 , , , cord-010119-t1x9gknd 2112 33 Marcus Marcus NNP cord-010119-t1x9gknd 2112 34 J J NNP cord-010119-t1x9gknd 2112 35 Schultz Schultz NNP cord-010119-t1x9gknd 2112 36 1 1 CD cord-010119-t1x9gknd 2112 37 , , , cord-010119-t1x9gknd 2112 38 Robin Robin NNP cord-010119-t1x9gknd 2112 39 van van NNP cord-010119-t1x9gknd 2112 40 Bruggen Bruggen NNP cord-010119-t1x9gknd 2112 41 2 2 CD cord-010119-t1x9gknd 2112 42 and and CC cord-010119-t1x9gknd 2112 43 Nicole Nicole NNP cord-010119-t1x9gknd 2112 44 P P NNP cord-010119-t1x9gknd 2112 45 Juffermans Juffermans NNP cord-010119-t1x9gknd 2112 46 1 1 CD cord-010119-t1x9gknd 2112 47 . . . cord-010119-t1x9gknd 2113 1 1 1 LS cord-010119-t1x9gknd 2113 2 Academic Academic NNP cord-010119-t1x9gknd 2113 3 Medical Medical NNP cord-010119-t1x9gknd 2113 4 Center Center NNP cord-010119-t1x9gknd 2113 5 , , , cord-010119-t1x9gknd 2113 6 2 2 CD cord-010119-t1x9gknd 2113 7 Sanquin Sanquin NNP cord-010119-t1x9gknd 2113 8 Research Research NNP cord-010119-t1x9gknd 2113 9 and and CC cord-010119-t1x9gknd 2113 10 Landsteiner Landsteiner NNP cord-010119-t1x9gknd 2113 11 Laboratory Laboratory NNP cord-010119-t1x9gknd 2113 12 , , , cord-010119-t1x9gknd 2113 13 3 3 CD cord-010119-t1x9gknd 2113 14 VU VU NNP cord-010119-t1x9gknd 2113 15 University University NNP cord-010119-t1x9gknd 2113 16 Medical Medical NNP cord-010119-t1x9gknd 2113 17 Center Center NNP cord-010119-t1x9gknd 2113 18 , , , cord-010119-t1x9gknd 2113 19 4 4 CD cord-010119-t1x9gknd 2113 20 University University NNP cord-010119-t1x9gknd 2113 21 Medical Medical NNP cord-010119-t1x9gknd 2113 22 Center Center NNP cord-010119-t1x9gknd 2113 23 Utrecht Utrecht NNP cord-010119-t1x9gknd 2113 24 Background Background NNP cord-010119-t1x9gknd 2113 25 / / SYM cord-010119-t1x9gknd 2113 26 Case Case NNP cord-010119-t1x9gknd 2113 27 Studies Studies NNPS cord-010119-t1x9gknd 2113 28 : : : cord-010119-t1x9gknd 2113 29 Anemia anemia NN cord-010119-t1x9gknd 2113 30 due due JJ cord-010119-t1x9gknd 2113 31 to to IN cord-010119-t1x9gknd 2113 32 inflammatory inflammatory JJ cord-010119-t1x9gknd 2113 33 processes process NNS cord-010119-t1x9gknd 2113 34 ( ( -LRB- cord-010119-t1x9gknd 2113 35 anemia anemia NN cord-010119-t1x9gknd 2113 36 of of IN cord-010119-t1x9gknd 2113 37 inflammation inflammation NN cord-010119-t1x9gknd 2113 38 , , , cord-010119-t1x9gknd 2113 39 AI AI NNP cord-010119-t1x9gknd 2113 40 ) ) -RRB- cord-010119-t1x9gknd 2113 41 frequently frequently RB cord-010119-t1x9gknd 2113 42 occurs occur VBZ cord-010119-t1x9gknd 2113 43 in in IN cord-010119-t1x9gknd 2113 44 critically critically RB cord-010119-t1x9gknd 2113 45 ill ill JJ cord-010119-t1x9gknd 2113 46 patients patient NNS cord-010119-t1x9gknd 2113 47 . . . cord-010119-t1x9gknd 2114 1 In in IN cord-010119-t1x9gknd 2114 2 AI AI NNP cord-010119-t1x9gknd 2114 3 , , , cord-010119-t1x9gknd 2114 4 inflammation inflammation NN cord-010119-t1x9gknd 2114 5 - - HYPH cord-010119-t1x9gknd 2114 6 induced induce VBN cord-010119-t1x9gknd 2114 7 hepcidin hepcidin NNP cord-010119-t1x9gknd 2114 8 decreases decrease VBZ cord-010119-t1x9gknd 2114 9 iron iron NN cord-010119-t1x9gknd 2114 10 availability availability NN cord-010119-t1x9gknd 2114 11 , , , cord-010119-t1x9gknd 2114 12 a a DT cord-010119-t1x9gknd 2114 13 process process NN cord-010119-t1x9gknd 2114 14 that that WDT cord-010119-t1x9gknd 2114 15 is be VBZ cord-010119-t1x9gknd 2114 16 thought think VBN cord-010119-t1x9gknd 2114 17 to to TO cord-010119-t1x9gknd 2114 18 be be VB cord-010119-t1x9gknd 2114 19 regulated regulate VBN cord-010119-t1x9gknd 2114 20 by by IN cord-010119-t1x9gknd 2114 21 erythroferrone erythroferrone NN cord-010119-t1x9gknd 2114 22 , , , cord-010119-t1x9gknd 2114 23 which which WDT cord-010119-t1x9gknd 2114 24 impact impact NN cord-010119-t1x9gknd 2114 25 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 2114 26 . . . cord-010119-t1x9gknd 2115 1 Knowledge knowledge NN cord-010119-t1x9gknd 2115 2 on on IN cord-010119-t1x9gknd 2115 3 changes change NNS cord-010119-t1x9gknd 2115 4 in in IN cord-010119-t1x9gknd 2115 5 iron iron NN cord-010119-t1x9gknd 2115 6 metabolism metabolism NN cord-010119-t1x9gknd 2115 7 during during IN cord-010119-t1x9gknd 2115 8 the the DT cord-010119-t1x9gknd 2115 9 course course NN cord-010119-t1x9gknd 2115 10 of of IN cord-010119-t1x9gknd 2115 11 AI AI NNP cord-010119-t1x9gknd 2115 12 is be VBZ cord-010119-t1x9gknd 2115 13 limited limit VBN cord-010119-t1x9gknd 2115 14 , , , cord-010119-t1x9gknd 2115 15 hampering hamper VBG cord-010119-t1x9gknd 2115 16 the the DT cord-010119-t1x9gknd 2115 17 development development NN cord-010119-t1x9gknd 2115 18 of of IN cord-010119-t1x9gknd 2115 19 strategies strategy NNS cord-010119-t1x9gknd 2115 20 to to TO cord-010119-t1x9gknd 2115 21 counteract counteract VB cord-010119-t1x9gknd 2115 22 AI AI NNP cord-010119-t1x9gknd 2115 23 . . . cord-010119-t1x9gknd 2116 1 This this DT cord-010119-t1x9gknd 2116 2 study study NN cord-010119-t1x9gknd 2116 3 aimed aim VBD cord-010119-t1x9gknd 2116 4 to to TO cord-010119-t1x9gknd 2116 5 investigate investigate VB cord-010119-t1x9gknd 2116 6 the the DT cord-010119-t1x9gknd 2116 7 dynamics dynamic NNS cord-010119-t1x9gknd 2116 8 of of IN cord-010119-t1x9gknd 2116 9 parameters parameter NNS cord-010119-t1x9gknd 2116 10 of of IN cord-010119-t1x9gknd 2116 11 iron iron NN cord-010119-t1x9gknd 2116 12 metabolism metabolism NN cord-010119-t1x9gknd 2116 13 during during IN cord-010119-t1x9gknd 2116 14 the the DT cord-010119-t1x9gknd 2116 15 development development NN cord-010119-t1x9gknd 2116 16 of of IN cord-010119-t1x9gknd 2116 17 AI AI NNP cord-010119-t1x9gknd 2116 18 in in IN cord-010119-t1x9gknd 2116 19 critically critically RB cord-010119-t1x9gknd 2116 20 ill ill JJ cord-010119-t1x9gknd 2116 21 patients patient NNS cord-010119-t1x9gknd 2116 22 . . . cord-010119-t1x9gknd 2117 1 Study Study NNP cord-010119-t1x9gknd 2117 2 Design Design NNP cord-010119-t1x9gknd 2117 3 / / SYM cord-010119-t1x9gknd 2117 4 Methods method NNS cord-010119-t1x9gknd 2117 5 : : : cord-010119-t1x9gknd 2117 6 A a DT cord-010119-t1x9gknd 2117 7 case case NN cord-010119-t1x9gknd 2117 8 control control NN cord-010119-t1x9gknd 2117 9 study study NN cord-010119-t1x9gknd 2117 10 was be VBD cord-010119-t1x9gknd 2117 11 performed perform VBN cord-010119-t1x9gknd 2117 12 in in IN cord-010119-t1x9gknd 2117 13 2 2 CD cord-010119-t1x9gknd 2117 14 tertiary tertiary JJ cord-010119-t1x9gknd 2117 15 ICUs icus NN cord-010119-t1x9gknd 2117 16 in in IN cord-010119-t1x9gknd 2117 17 The the DT cord-010119-t1x9gknd 2117 18 Netherlands Netherlands NNP cord-010119-t1x9gknd 2117 19 comparing compare VBG cord-010119-t1x9gknd 2117 20 30 30 CD cord-010119-t1x9gknd 2117 21 patients patient NNS cord-010119-t1x9gknd 2117 22 who who WP cord-010119-t1x9gknd 2117 23 developed develop VBD cord-010119-t1x9gknd 2117 24 AI AI NNP cord-010119-t1x9gknd 2117 25 during during IN cord-010119-t1x9gknd 2117 26 ICU ICU NNP cord-010119-t1x9gknd 2117 27 stay stay VBP cord-010119-t1x9gknd 2117 28 with with IN cord-010119-t1x9gknd 2117 29 3 3 CD cord-010119-t1x9gknd 2117 30 control control NN cord-010119-t1x9gknd 2117 31 groups group NNS cord-010119-t1x9gknd 2117 32 : : : cord-010119-t1x9gknd 2117 33 30 30 CD cord-010119-t1x9gknd 2117 34 non non JJ cord-010119-t1x9gknd 2117 35 - - JJ cord-010119-t1x9gknd 2117 36 anemic anemic JJ cord-010119-t1x9gknd 2117 37 patients patient NNS cord-010119-t1x9gknd 2117 38 with with IN cord-010119-t1x9gknd 2117 39 sepsis sepsis NN cord-010119-t1x9gknd 2117 40 , , , cord-010119-t1x9gknd 2117 41 30 30 CD cord-010119-t1x9gknd 2117 42 non non JJ cord-010119-t1x9gknd 2117 43 - - JJ cord-010119-t1x9gknd 2117 44 anemic anemic JJ cord-010119-t1x9gknd 2117 45 patients patient NNS cord-010119-t1x9gknd 2117 46 without without IN cord-010119-t1x9gknd 2117 47 sepsis sepsis NN cord-010119-t1x9gknd 2117 48 , , , cord-010119-t1x9gknd 2117 49 and and CC cord-010119-t1x9gknd 2117 50 10 10 CD cord-010119-t1x9gknd 2117 51 patients patient NNS cord-010119-t1x9gknd 2117 52 with with IN cord-010119-t1x9gknd 2117 53 anemia anemia NN cord-010119-t1x9gknd 2117 54 due due IN cord-010119-t1x9gknd 2117 55 to to IN cord-010119-t1x9gknd 2117 56 acute acute JJ cord-010119-t1x9gknd 2117 57 blood blood NN cord-010119-t1x9gknd 2117 58 loss loss NN cord-010119-t1x9gknd 2117 59 . . . cord-010119-t1x9gknd 2118 1 Patients patient NNS cord-010119-t1x9gknd 2118 2 were be VBD cord-010119-t1x9gknd 2118 3 matched match VBN cord-010119-t1x9gknd 2118 4 on on IN cord-010119-t1x9gknd 2118 5 age age NN cord-010119-t1x9gknd 2118 6 and and CC cord-010119-t1x9gknd 2118 7 sex sex NN cord-010119-t1x9gknd 2118 8 . . . cord-010119-t1x9gknd 2119 1 A a DT cord-010119-t1x9gknd 2119 2 linear linear JJ cord-010119-t1x9gknd 2119 3 mixed mixed JJ cord-010119-t1x9gknd 2119 4 model model NN cord-010119-t1x9gknd 2119 5 was be VBD cord-010119-t1x9gknd 2119 6 used use VBN cord-010119-t1x9gknd 2119 7 to to TO cord-010119-t1x9gknd 2119 8 assess assess VB cord-010119-t1x9gknd 2119 9 differences difference NNS cord-010119-t1x9gknd 2119 10 in in IN cord-010119-t1x9gknd 2119 11 parameters parameter NNS cord-010119-t1x9gknd 2119 12 of of IN cord-010119-t1x9gknd 2119 13 iron iron NN cord-010119-t1x9gknd 2119 14 metabolism metabolism NN cord-010119-t1x9gknd 2119 15 between between IN cord-010119-t1x9gknd 2119 16 groups group NNS cord-010119-t1x9gknd 2119 17 and and CC cord-010119-t1x9gknd 2119 18 over over IN cord-010119-t1x9gknd 2119 19 time time NN cord-010119-t1x9gknd 2119 20 . . . cord-010119-t1x9gknd 2120 1 Results result NNS cord-010119-t1x9gknd 2120 2 / / SYM cord-010119-t1x9gknd 2120 3 Findings finding NNS cord-010119-t1x9gknd 2120 4 : : : cord-010119-t1x9gknd 2121 1 In in IN cord-010119-t1x9gknd 2121 2 patients patient NNS cord-010119-t1x9gknd 2121 3 with with IN cord-010119-t1x9gknd 2121 4 AI AI NNP cord-010119-t1x9gknd 2121 5 , , , cord-010119-t1x9gknd 2121 6 levels level NNS cord-010119-t1x9gknd 2121 7 of of IN cord-010119-t1x9gknd 2121 8 iron iron NN cord-010119-t1x9gknd 2121 9 , , , cord-010119-t1x9gknd 2121 10 transferrin transferrin NN cord-010119-t1x9gknd 2121 11 and and CC cord-010119-t1x9gknd 2121 12 transferrin transferrin NN cord-010119-t1x9gknd 2121 13 saturation saturation NN cord-010119-t1x9gknd 2121 14 decreased decrease VBD cord-010119-t1x9gknd 2121 15 already already RB cord-010119-t1x9gknd 2121 16 prior prior RB cord-010119-t1x9gknd 2121 17 to to IN cord-010119-t1x9gknd 2121 18 the the DT cord-010119-t1x9gknd 2121 19 development development NN cord-010119-t1x9gknd 2121 20 of of IN cord-010119-t1x9gknd 2121 21 anemia anemia NN cord-010119-t1x9gknd 2121 22 , , , cord-010119-t1x9gknd 2121 23 with with IN cord-010119-t1x9gknd 2121 24 lower low JJR cord-010119-t1x9gknd 2121 25 levels level NNS cord-010119-t1x9gknd 2121 26 compared compare VBN cord-010119-t1x9gknd 2121 27 to to IN cord-010119-t1x9gknd 2121 28 controls control NNS cord-010119-t1x9gknd 2121 29 ( ( -LRB- cord-010119-t1x9gknd 2121 30 table table NN cord-010119-t1x9gknd 2121 31 ) ) -RRB- cord-010119-t1x9gknd 2121 32 . . . cord-010119-t1x9gknd 2122 1 Ferritin ferritin NN cord-010119-t1x9gknd 2122 2 and and CC cord-010119-t1x9gknd 2122 3 hepcidin hepcidin NNS cord-010119-t1x9gknd 2122 4 were be VBD cord-010119-t1x9gknd 2122 5 increased increase VBN cord-010119-t1x9gknd 2122 6 in in IN cord-010119-t1x9gknd 2122 7 AI AI NNP cord-010119-t1x9gknd 2122 8 compared compare VBN cord-010119-t1x9gknd 2122 9 to to IN cord-010119-t1x9gknd 2122 10 controls control NNS cord-010119-t1x9gknd 2122 11 . . . cord-010119-t1x9gknd 2123 1 In in IN cord-010119-t1x9gknd 2123 2 the the DT cord-010119-t1x9gknd 2123 3 course course NN cord-010119-t1x9gknd 2123 4 of of IN cord-010119-t1x9gknd 2123 5 AI AI NNP cord-010119-t1x9gknd 2123 6 development development NN cord-010119-t1x9gknd 2123 7 , , , cord-010119-t1x9gknd 2123 8 erythroferrone erythroferrone NN cord-010119-t1x9gknd 2123 9 decreased decrease VBD cord-010119-t1x9gknd 2123 10 . . . cord-010119-t1x9gknd 2124 1 Differences difference NNS cord-010119-t1x9gknd 2124 2 in in IN cord-010119-t1x9gknd 2124 3 iron iron NN cord-010119-t1x9gknd 2124 4 metabolism metabolism NN cord-010119-t1x9gknd 2124 5 between between IN cord-010119-t1x9gknd 2124 6 groups group NNS cord-010119-t1x9gknd 2124 7 were be VBD cord-010119-t1x9gknd 2124 8 not not RB cord-010119-t1x9gknd 2124 9 influenced influence VBN cord-010119-t1x9gknd 2124 10 by by IN cord-010119-t1x9gknd 2124 11 disease disease NN cord-010119-t1x9gknd 2124 12 severity severity NN cord-010119-t1x9gknd 2124 13 . . . cord-010119-t1x9gknd 2125 1 Patients patient NNS cord-010119-t1x9gknd 2125 2 with with IN cord-010119-t1x9gknd 2125 3 AI AI NNP cord-010119-t1x9gknd 2125 4 differed differ VBD cord-010119-t1x9gknd 2125 5 from from IN cord-010119-t1x9gknd 2125 6 patients patient NNS cord-010119-t1x9gknd 2125 7 with with IN cord-010119-t1x9gknd 2125 8 anemia anemia NN cord-010119-t1x9gknd 2125 9 due due IN cord-010119-t1x9gknd 2125 10 to to IN cord-010119-t1x9gknd 2125 11 acute acute JJ cord-010119-t1x9gknd 2125 12 blood blood NN cord-010119-t1x9gknd 2125 13 loss loss NN cord-010119-t1x9gknd 2125 14 , , , cord-010119-t1x9gknd 2125 15 the the DT cord-010119-t1x9gknd 2125 16 latter latter JJ cord-010119-t1x9gknd 2125 17 was be VBD cord-010119-t1x9gknd 2125 18 characterized characterize VBN cord-010119-t1x9gknd 2125 19 by by IN cord-010119-t1x9gknd 2125 20 high high JJ cord-010119-t1x9gknd 2125 21 iron iron NN cord-010119-t1x9gknd 2125 22 ( ( -LRB- cord-010119-t1x9gknd 2125 23 15.4 15.4 CD cord-010119-t1x9gknd 2125 24 vs. vs. IN cord-010119-t1x9gknd 2125 25 2.9 2.9 CD cord-010119-t1x9gknd 2125 26 mmol mmol JJ cord-010119-t1x9gknd 2125 27 / / SYM cord-010119-t1x9gknd 2125 28 L L NNP cord-010119-t1x9gknd 2125 29 , , , cord-010119-t1x9gknd 2125 30 p<0.001 p<0.001 CD cord-010119-t1x9gknd 2125 31 ) ) -RRB- cord-010119-t1x9gknd 2125 32 and and CC cord-010119-t1x9gknd 2125 33 transferrin transferrin NN cord-010119-t1x9gknd 2125 34 saturation saturation NN cord-010119-t1x9gknd 2125 35 ( ( -LRB- cord-010119-t1x9gknd 2125 36 53 53 CD cord-010119-t1x9gknd 2125 37 vs. vs. CC cord-010119-t1x9gknd 2125 38 9 9 CD cord-010119-t1x9gknd 2125 39 % % NN cord-010119-t1x9gknd 2125 40 , , , cord-010119-t1x9gknd 2125 41 p<0.001 p<0.001 CD cord-010119-t1x9gknd 2125 42 ) ) -RRB- cord-010119-t1x9gknd 2125 43 , , , cord-010119-t1x9gknd 2125 44 and and CC cord-010119-t1x9gknd 2125 45 low low JJ cord-010119-t1x9gknd 2125 46 ferritin ferritin NN cord-010119-t1x9gknd 2125 47 ( ( -LRB- cord-010119-t1x9gknd 2125 48 104 104 CD cord-010119-t1x9gknd 2125 49 vs. vs. IN cord-010119-t1x9gknd 2125 50 645 645 CD cord-010119-t1x9gknd 2125 51 mg mg NNP cord-010119-t1x9gknd 2125 52 / / SYM cord-010119-t1x9gknd 2125 53 L L NNP cord-010119-t1x9gknd 2125 54 , , , cord-010119-t1x9gknd 2125 55 p<0.001 p<0.001 CD cord-010119-t1x9gknd 2125 56 ) ) -RRB- cord-010119-t1x9gknd 2125 57 . . . cord-010119-t1x9gknd 2126 1 Conclusion conclusion NN cord-010119-t1x9gknd 2126 2 : : : cord-010119-t1x9gknd 2127 1 In in IN cord-010119-t1x9gknd 2127 2 critically critically RB cord-010119-t1x9gknd 2127 3 ill ill JJ cord-010119-t1x9gknd 2127 4 patients patient NNS cord-010119-t1x9gknd 2127 5 with with IN cord-010119-t1x9gknd 2127 6 AI AI NNP cord-010119-t1x9gknd 2127 7 , , , cord-010119-t1x9gknd 2127 8 iron iron NN cord-010119-t1x9gknd 2127 9 metabolism metabolism NN cord-010119-t1x9gknd 2127 10 is be VBZ cord-010119-t1x9gknd 2127 11 already already RB cord-010119-t1x9gknd 2127 12 altered alter VBN cord-010119-t1x9gknd 2127 13 prior prior RB cord-010119-t1x9gknd 2127 14 to to IN cord-010119-t1x9gknd 2127 15 the the DT cord-010119-t1x9gknd 2127 16 development development NN cord-010119-t1x9gknd 2127 17 of of IN cord-010119-t1x9gknd 2127 18 anemia anemia NN cord-010119-t1x9gknd 2127 19 , , , cord-010119-t1x9gknd 2127 20 suggesting suggest VBG cord-010119-t1x9gknd 2127 21 a a DT cord-010119-t1x9gknd 2127 22 potential potential JJ cord-010119-t1x9gknd 2127 23 window window NN cord-010119-t1x9gknd 2127 24 of of IN cord-010119-t1x9gknd 2127 25 opportunity opportunity NN cord-010119-t1x9gknd 2127 26 for for IN cord-010119-t1x9gknd 2127 27 therapy therapy NN cord-010119-t1x9gknd 2127 28 . . . cord-010119-t1x9gknd 2128 1 Iron iron NN cord-010119-t1x9gknd 2128 2 metabolism metabolism NN cord-010119-t1x9gknd 2128 3 in in IN cord-010119-t1x9gknd 2128 4 AI AI NNP cord-010119-t1x9gknd 2128 5 is be VBZ cord-010119-t1x9gknd 2128 6 more more RBR cord-010119-t1x9gknd 2128 7 disturbed disturbed JJ cord-010119-t1x9gknd 2128 8 than than IN cord-010119-t1x9gknd 2128 9 in in IN cord-010119-t1x9gknd 2128 10 non non JJ cord-010119-t1x9gknd 2128 11 - - JJ cord-010119-t1x9gknd 2128 12 anemic anemic JJ cord-010119-t1x9gknd 2128 13 septic septic JJ cord-010119-t1x9gknd 2128 14 controls control NNS cord-010119-t1x9gknd 2128 15 , , , cord-010119-t1x9gknd 2128 16 irrespective irrespective RB cord-010119-t1x9gknd 2128 17 of of IN cord-010119-t1x9gknd 2128 18 disease disease NN cord-010119-t1x9gknd 2128 19 severity severity NN cord-010119-t1x9gknd 2128 20 , , , cord-010119-t1x9gknd 2128 21 indicating indicate VBG cord-010119-t1x9gknd 2128 22 that that IN cord-010119-t1x9gknd 2128 23 AI AI NNP cord-010119-t1x9gknd 2128 24 is be VBZ cord-010119-t1x9gknd 2128 25 not not RB cord-010119-t1x9gknd 2128 26 solely solely RB cord-010119-t1x9gknd 2128 27 determined determine VBN cord-010119-t1x9gknd 2128 28 by by IN cord-010119-t1x9gknd 2128 29 severity severity NN cord-010119-t1x9gknd 2128 30 of of IN cord-010119-t1x9gknd 2128 31 inflammation inflammation NN cord-010119-t1x9gknd 2128 32 . . . cord-010119-t1x9gknd 2129 1 Iron iron NN cord-010119-t1x9gknd 2129 2 metabolism metabolism NN cord-010119-t1x9gknd 2129 3 in in IN cord-010119-t1x9gknd 2129 4 AI AI NNP cord-010119-t1x9gknd 2129 5 patients patient NNS cord-010119-t1x9gknd 2129 6 differs differ VBZ cord-010119-t1x9gknd 2129 7 from from IN cord-010119-t1x9gknd 2129 8 patients patient NNS cord-010119-t1x9gknd 2129 9 with with IN cord-010119-t1x9gknd 2129 10 acute acute JJ cord-010119-t1x9gknd 2129 11 blood blood NN cord-010119-t1x9gknd 2129 12 loss loss NN cord-010119-t1x9gknd 2129 13 , , , cord-010119-t1x9gknd 2129 14 suggesting suggest VBG cord-010119-t1x9gknd 2129 15 that that IN cord-010119-t1x9gknd 2129 16 efforts effort NNS cord-010119-t1x9gknd 2129 17 to to TO cord-010119-t1x9gknd 2129 18 modulate modulate VB cord-010119-t1x9gknd 2129 19 iron iron NN cord-010119-t1x9gknd 2129 20 metabolism metabolism NN cord-010119-t1x9gknd 2129 21 in in IN cord-010119-t1x9gknd 2129 22 anemic anemic JJ cord-010119-t1x9gknd 2129 23 ICU ICU NNP cord-010119-t1x9gknd 2129 24 patients patient NNS cord-010119-t1x9gknd 2129 25 should should MD cord-010119-t1x9gknd 2129 26 take take VB cord-010119-t1x9gknd 2129 27 the the DT cord-010119-t1x9gknd 2129 28 cause cause NN cord-010119-t1x9gknd 2129 29 of of IN cord-010119-t1x9gknd 2129 30 anemia anemia NN cord-010119-t1x9gknd 2129 31 into into IN cord-010119-t1x9gknd 2129 32 account account NN cord-010119-t1x9gknd 2129 33 . . . cord-010119-t1x9gknd 2130 1 Clinical clinical JJ cord-010119-t1x9gknd 2130 2 Oral Oral NNP cord-010119-t1x9gknd 2130 3 Abstract Abstract NNP cord-010119-t1x9gknd 2130 4 Session session NN cord-010119-t1x9gknd 2130 5 : : : cord-010119-t1x9gknd 2131 1 Novel Novel NNP cord-010119-t1x9gknd 2131 2 Approaches approach NNS cord-010119-t1x9gknd 2131 3 to to IN cord-010119-t1x9gknd 2131 4 Processing processing NN cord-010119-t1x9gknd 2131 5 and and CC cord-010119-t1x9gknd 2131 6 Assessing assessing NN cord-010119-t1x9gknd 2132 1 Cell cell NN cord-010119-t1x9gknd 2132 2 Therapy therapy NN cord-010119-t1x9gknd 2132 3 Products product NNS cord-010119-t1x9gknd 2132 4 A A NNP cord-010119-t1x9gknd 2132 5 Paradigm Paradigm NNP cord-010119-t1x9gknd 2132 6 Shift Shift NNP cord-010119-t1x9gknd 2132 7 in in IN cord-010119-t1x9gknd 2132 8 Stem Stem NNP cord-010119-t1x9gknd 2132 9 Cell cell NN cord-010119-t1x9gknd 2132 10 Isolation isolation NN cord-010119-t1x9gknd 2132 11 and and CC cord-010119-t1x9gknd 2132 12 Storage storage NN cord-010119-t1x9gknd 2133 1 Jeffrey Jeffrey NNP cord-010119-t1x9gknd 2133 2 Drew draw VBD cord-010119-t1x9gknd 2133 3 * * NFP cord-010119-t1x9gknd 2133 4 . . . cord-010119-t1x9gknd 2134 1 Cells4life cells4life NN cord-010119-t1x9gknd 2135 1 Group Group NNP cord-010119-t1x9gknd 2135 2 LLP LLP NNP cord-010119-t1x9gknd 2135 3 Background Background NNP cord-010119-t1x9gknd 2135 4 / / SYM cord-010119-t1x9gknd 2135 5 Case Case NNP cord-010119-t1x9gknd 2135 6 Studies Studies NNPS cord-010119-t1x9gknd 2135 7 : : : cord-010119-t1x9gknd 2136 1 Widespread widespread JJ cord-010119-t1x9gknd 2136 2 use use NN cord-010119-t1x9gknd 2136 3 of of IN cord-010119-t1x9gknd 2136 4 umbilical umbilical JJ cord-010119-t1x9gknd 2136 5 cord cord NN cord-010119-t1x9gknd 2136 6 blood blood NN cord-010119-t1x9gknd 2136 7 is be VBZ cord-010119-t1x9gknd 2136 8 limited limit VBN cord-010119-t1x9gknd 2136 9 by by IN cord-010119-t1x9gknd 2136 10 processing processing NN cord-010119-t1x9gknd 2136 11 yield yield NN cord-010119-t1x9gknd 2136 12 and and CC cord-010119-t1x9gknd 2136 13 post post JJ cord-010119-t1x9gknd 2136 14 - - JJ cord-010119-t1x9gknd 2136 15 thaw thaw VB cord-010119-t1x9gknd 2136 16 recovery recovery NN cord-010119-t1x9gknd 2136 17 of of IN cord-010119-t1x9gknd 2136 18 viable viable JJ cord-010119-t1x9gknd 2136 19 nucleated nucleated JJ cord-010119-t1x9gknd 2136 20 cells cell NNS cord-010119-t1x9gknd 2136 21 . . . cord-010119-t1x9gknd 2137 1 The the DT cord-010119-t1x9gknd 2137 2 recommended recommend VBN cord-010119-t1x9gknd 2137 3 therapeutic therapeutic JJ cord-010119-t1x9gknd 2137 4 cell cell NN cord-010119-t1x9gknd 2137 5 dose dose NN cord-010119-t1x9gknd 2137 6 is be VBZ cord-010119-t1x9gknd 2137 7 approximately approximately RB cord-010119-t1x9gknd 2137 8 2.5 2.5 CD cord-010119-t1x9gknd 2137 9 x x SYM cord-010119-t1x9gknd 2137 10 10 10 CD cord-010119-t1x9gknd 2137 11 7 7 CD cord-010119-t1x9gknd 2137 12 cells cell NNS cord-010119-t1x9gknd 2137 13 per per IN cord-010119-t1x9gknd 2137 14 kg kg NN cord-010119-t1x9gknd 2137 15 body body NN cord-010119-t1x9gknd 2137 16 weight weight NN cord-010119-t1x9gknd 2137 17 indicating indicate VBG cord-010119-t1x9gknd 2137 18 that that IN cord-010119-t1x9gknd 2137 19 a a DT cord-010119-t1x9gknd 2137 20 single single JJ cord-010119-t1x9gknd 2137 21 cord cord NN cord-010119-t1x9gknd 2137 22 unit unit NN cord-010119-t1x9gknd 2137 23 may may MD cord-010119-t1x9gknd 2137 24 be be VB cord-010119-t1x9gknd 2137 25 insufficent insufficent JJ cord-010119-t1x9gknd 2137 26 to to TO cord-010119-t1x9gknd 2137 27 treat treat VB cord-010119-t1x9gknd 2137 28 larger large JJR cord-010119-t1x9gknd 2137 29 individuals individual NNS cord-010119-t1x9gknd 2137 30 . . . cord-010119-t1x9gknd 2138 1 Cell cell NN cord-010119-t1x9gknd 2138 2 isolation isolation NN cord-010119-t1x9gknd 2138 3 methods method NNS cord-010119-t1x9gknd 2138 4 were be VBD cord-010119-t1x9gknd 2138 5 developed develop VBN cord-010119-t1x9gknd 2138 6 to to TO cord-010119-t1x9gknd 2138 7 remove remove VB cord-010119-t1x9gknd 2138 8 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 2138 9 whilst whilst IN cord-010119-t1x9gknd 2138 10 recovering recover VBG cord-010119-t1x9gknd 2138 11 the the DT cord-010119-t1x9gknd 2138 12 white white JJ cord-010119-t1x9gknd 2138 13 cell cell NN cord-010119-t1x9gknd 2138 14 fraction fraction NN cord-010119-t1x9gknd 2138 15 ( ( -LRB- cord-010119-t1x9gknd 2138 16 WCF WCF NNP cord-010119-t1x9gknd 2138 17 ) ) -RRB- cord-010119-t1x9gknd 2138 18 . . . cord-010119-t1x9gknd 2139 1 However however RB cord-010119-t1x9gknd 2139 2 , , , cord-010119-t1x9gknd 2139 3 all all DT cord-010119-t1x9gknd 2139 4 current current JJ cord-010119-t1x9gknd 2139 5 methods method NNS cord-010119-t1x9gknd 2139 6 result result VBP cord-010119-t1x9gknd 2139 7 in in IN cord-010119-t1x9gknd 2139 8 significant significant JJ cord-010119-t1x9gknd 2139 9 loss loss NN cord-010119-t1x9gknd 2139 10 of of IN cord-010119-t1x9gknd 2139 11 the the DT cord-010119-t1x9gknd 2139 12 WCF WCF NNP cord-010119-t1x9gknd 2139 13 , , , cord-010119-t1x9gknd 2139 14 some some DT cord-010119-t1x9gknd 2139 15 up up IN cord-010119-t1x9gknd 2139 16 to to TO cord-010119-t1x9gknd 2139 17 65 65 CD cord-010119-t1x9gknd 2139 18 % % NN cord-010119-t1x9gknd 2139 19 , , , cord-010119-t1x9gknd 2139 20 whilst whilst IN cord-010119-t1x9gknd 2139 21 leaving leave VBG cord-010119-t1x9gknd 2139 22 25 25 CD cord-010119-t1x9gknd 2139 23 % % NN cord-010119-t1x9gknd 2139 24 of of IN cord-010119-t1x9gknd 2139 25 the the DT cord-010119-t1x9gknd 2139 26 starting starting NN cord-010119-t1x9gknd 2139 27 volume volume NN cord-010119-t1x9gknd 2139 28 of of IN cord-010119-t1x9gknd 2139 29 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 2139 30 . . . cord-010119-t1x9gknd 2140 1 Additionally additionally RB cord-010119-t1x9gknd 2140 2 , , , cord-010119-t1x9gknd 2140 3 there there EX cord-010119-t1x9gknd 2140 4 is be VBZ cord-010119-t1x9gknd 2140 5 an an DT cord-010119-t1x9gknd 2140 6 almost almost RB cord-010119-t1x9gknd 2140 7 total total JJ cord-010119-t1x9gknd 2140 8 loss loss NN cord-010119-t1x9gknd 2140 9 of of IN cord-010119-t1x9gknd 2140 10 potentially potentially RB cord-010119-t1x9gknd 2140 11 important important JJ cord-010119-t1x9gknd 2140 12 , , , cord-010119-t1x9gknd 2140 13 low low JJ cord-010119-t1x9gknd 2140 14 abundance abundance NN cord-010119-t1x9gknd 2140 15 cellular cellular JJ cord-010119-t1x9gknd 2140 16 subsets subset NNS cord-010119-t1x9gknd 2140 17 . . . cord-010119-t1x9gknd 2141 1 The the DT cord-010119-t1x9gknd 2141 2 use use NN cord-010119-t1x9gknd 2141 3 of of IN cord-010119-t1x9gknd 2141 4 cord cord NN cord-010119-t1x9gknd 2141 5 blood blood NN cord-010119-t1x9gknd 2141 6 for for IN cord-010119-t1x9gknd 2141 7 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 2141 8 reconsititution reconsititution NN cord-010119-t1x9gknd 2141 9 and and CC cord-010119-t1x9gknd 2141 10 in in IN cord-010119-t1x9gknd 2141 11 regenerative regenerative JJ cord-010119-t1x9gknd 2141 12 medicine medicine NN cord-010119-t1x9gknd 2141 13 would would MD cord-010119-t1x9gknd 2141 14 be be VB cord-010119-t1x9gknd 2141 15 widened widen VBN cord-010119-t1x9gknd 2141 16 if if IN cord-010119-t1x9gknd 2141 17 processing processing NN cord-010119-t1x9gknd 2141 18 methods method NNS cord-010119-t1x9gknd 2141 19 improved improve VBD cord-010119-t1x9gknd 2141 20 postprocessing postprocessing NN cord-010119-t1x9gknd 2141 21 and and CC cord-010119-t1x9gknd 2141 22 post post NN cord-010119-t1x9gknd 2141 23 - - JJ cord-010119-t1x9gknd 2141 24 thaw thaw VB cord-010119-t1x9gknd 2141 25 viable viable JJ cord-010119-t1x9gknd 2141 26 cell cell NN cord-010119-t1x9gknd 2141 27 recovery recovery NN cord-010119-t1x9gknd 2141 28 . . . cord-010119-t1x9gknd 2142 1 Study Study NNP cord-010119-t1x9gknd 2142 2 Design Design NNP cord-010119-t1x9gknd 2142 3 / / SYM cord-010119-t1x9gknd 2142 4 Methods method NNS cord-010119-t1x9gknd 2142 5 : : : cord-010119-t1x9gknd 2142 6 We -PRON- PRP cord-010119-t1x9gknd 2142 7 have have VBP cord-010119-t1x9gknd 2142 8 developed develop VBN cord-010119-t1x9gknd 2142 9 a a DT cord-010119-t1x9gknd 2142 10 solution solution NN cord-010119-t1x9gknd 2142 11 consisting consist VBG cord-010119-t1x9gknd 2142 12 of of IN cord-010119-t1x9gknd 2142 13 a a DT cord-010119-t1x9gknd 2142 14 defined define VBN cord-010119-t1x9gknd 2142 15 concentration concentration NN cord-010119-t1x9gknd 2142 16 of of IN cord-010119-t1x9gknd 2142 17 reagents reagent NNS cord-010119-t1x9gknd 2142 18 routinely routinely RB cord-010119-t1x9gknd 2142 19 used use VBN cord-010119-t1x9gknd 2142 20 in in IN cord-010119-t1x9gknd 2142 21 blood blood NN cord-010119-t1x9gknd 2142 22 therapy therapy NN cord-010119-t1x9gknd 2142 23 . . . cord-010119-t1x9gknd 2143 1 On on IN cord-010119-t1x9gknd 2143 2 combination combination NN cord-010119-t1x9gknd 2143 3 with with IN cord-010119-t1x9gknd 2143 4 blood blood NN cord-010119-t1x9gknd 2143 5 , , , cord-010119-t1x9gknd 2143 6 this this DT cord-010119-t1x9gknd 2143 7 solution solution NN cord-010119-t1x9gknd 2143 8 results result VBZ cord-010119-t1x9gknd 2143 9 in in IN cord-010119-t1x9gknd 2143 10 the the DT cord-010119-t1x9gknd 2143 11 selective selective JJ cord-010119-t1x9gknd 2143 12 sedimentation sedimentation NN cord-010119-t1x9gknd 2143 13 of of IN cord-010119-t1x9gknd 2143 14 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 2143 15 by by IN cord-010119-t1x9gknd 2143 16 gravity gravity NN cord-010119-t1x9gknd 2143 17 within within IN cord-010119-t1x9gknd 2143 18 30 30 CD cord-010119-t1x9gknd 2143 19 minutes minute NNS cord-010119-t1x9gknd 2143 20 . . . cord-010119-t1x9gknd 2144 1 The the DT cord-010119-t1x9gknd 2144 2 WCF WCF NNP cord-010119-t1x9gknd 2144 3 remains remain VBZ cord-010119-t1x9gknd 2144 4 in in IN cord-010119-t1x9gknd 2144 5 solution solution NN cord-010119-t1x9gknd 2144 6 and and CC cord-010119-t1x9gknd 2144 7 can can MD cord-010119-t1x9gknd 2144 8 be be VB cord-010119-t1x9gknd 2144 9 easily easily RB cord-010119-t1x9gknd 2144 10 separated separate VBN cord-010119-t1x9gknd 2144 11 from from IN cord-010119-t1x9gknd 2144 12 the the DT cord-010119-t1x9gknd 2144 13 erythrocyte erythrocyte NN cord-010119-t1x9gknd 2144 14 sediment sediment NN cord-010119-t1x9gknd 2144 15 . . . cord-010119-t1x9gknd 2145 1 The the DT cord-010119-t1x9gknd 2145 2 WCF WCF NNP cord-010119-t1x9gknd 2145 3 can can MD cord-010119-t1x9gknd 2145 4 then then RB cord-010119-t1x9gknd 2145 5 be be VB cord-010119-t1x9gknd 2145 6 concentrated concentrate VBN cord-010119-t1x9gknd 2145 7 by by IN cord-010119-t1x9gknd 2145 8 gentle gentle JJ cord-010119-t1x9gknd 2145 9 centrifugation centrifugation NN cord-010119-t1x9gknd 2145 10 into into IN cord-010119-t1x9gknd 2145 11 a a DT cord-010119-t1x9gknd 2145 12 small small JJ cord-010119-t1x9gknd 2145 13 volume volume NN cord-010119-t1x9gknd 2145 14 containing contain VBG cord-010119-t1x9gknd 2145 15 less less JJR cord-010119-t1x9gknd 2145 16 than than IN cord-010119-t1x9gknd 2145 17 1 1 CD cord-010119-t1x9gknd 2145 18 % % NN cord-010119-t1x9gknd 2145 19 of of IN cord-010119-t1x9gknd 2145 20 the the DT cord-010119-t1x9gknd 2145 21 original original JJ cord-010119-t1x9gknd 2145 22 erythrocyte erythrocyte NN cord-010119-t1x9gknd 2145 23 content content NN cord-010119-t1x9gknd 2145 24 . . . cord-010119-t1x9gknd 2146 1 The the DT cord-010119-t1x9gknd 2146 2 addition addition NN cord-010119-t1x9gknd 2146 3 of of IN cord-010119-t1x9gknd 2146 4 DMSO DMSO NNP cord-010119-t1x9gknd 2146 5 for for IN cord-010119-t1x9gknd 2146 6 cryogenic cryogenic JJ cord-010119-t1x9gknd 2146 7 storage storage NN cord-010119-t1x9gknd 2146 8 and and CC cord-010119-t1x9gknd 2146 9 controlled control VBN cord-010119-t1x9gknd 2146 10 freezing freezing NN cord-010119-t1x9gknd 2146 11 using use VBG cord-010119-t1x9gknd 2146 12 standard standard JJ cord-010119-t1x9gknd 2146 13 procedures procedure NNS cord-010119-t1x9gknd 2146 14 then then RB cord-010119-t1x9gknd 2146 15 completes complete VBZ cord-010119-t1x9gknd 2146 16 this this DT cord-010119-t1x9gknd 2146 17 simple simple JJ cord-010119-t1x9gknd 2146 18 process process NN cord-010119-t1x9gknd 2146 19 . . . cord-010119-t1x9gknd 2147 1 Results result NNS cord-010119-t1x9gknd 2147 2 / / SYM cord-010119-t1x9gknd 2147 3 Findings finding NNS cord-010119-t1x9gknd 2148 1 : : : cord-010119-t1x9gknd 2148 2 We -PRON- PRP cord-010119-t1x9gknd 2148 3 have have VBP cord-010119-t1x9gknd 2148 4 clearly clearly RB cord-010119-t1x9gknd 2148 5 demonstrated demonstrate VBN cord-010119-t1x9gknd 2148 6 that that IN cord-010119-t1x9gknd 2148 7 this this DT cord-010119-t1x9gknd 2148 8 method method NN cord-010119-t1x9gknd 2148 9 allows allow VBZ cord-010119-t1x9gknd 2148 10 almost almost RB cord-010119-t1x9gknd 2148 11 the the DT cord-010119-t1x9gknd 2148 12 entire entire JJ cord-010119-t1x9gknd 2148 13 WCF WCF NNP cord-010119-t1x9gknd 2148 14 to to TO cord-010119-t1x9gknd 2148 15 be be VB cord-010119-t1x9gknd 2148 16 isolated isolate VBN cord-010119-t1x9gknd 2148 17 and/or and/or CC cord-010119-t1x9gknd 2148 18 concentrated concentrate VBN cord-010119-t1x9gknd 2148 19 with with IN cord-010119-t1x9gknd 2148 20 only only RB cord-010119-t1x9gknd 2148 21 modest modest JJ cord-010119-t1x9gknd 2148 22 loss loss NN cord-010119-t1x9gknd 2148 23 of of IN cord-010119-t1x9gknd 2148 24 any any DT cord-010119-t1x9gknd 2148 25 of of IN cord-010119-t1x9gknd 2148 26 the the DT cord-010119-t1x9gknd 2148 27 cellular cellular JJ cord-010119-t1x9gknd 2148 28 sub sub NN cord-010119-t1x9gknd 2148 29 - - NNS cord-010119-t1x9gknd 2148 30 sets set NNS cord-010119-t1x9gknd 2148 31 thus thus RB cord-010119-t1x9gknd 2148 32 far far RB cord-010119-t1x9gknd 2148 33 examined examine VBN cord-010119-t1x9gknd 2148 34 . . . cord-010119-t1x9gknd 2149 1 In in IN cord-010119-t1x9gknd 2149 2 addition addition NN cord-010119-t1x9gknd 2149 3 to to IN cord-010119-t1x9gknd 2149 4 improving improve VBG cord-010119-t1x9gknd 2149 5 pre pre JJ cord-010119-t1x9gknd 2149 6 - - JJ cord-010119-t1x9gknd 2149 7 freeze freeze JJ cord-010119-t1x9gknd 2149 8 yields yield NNS cord-010119-t1x9gknd 2149 9 , , , cord-010119-t1x9gknd 2149 10 post post JJ cord-010119-t1x9gknd 2149 11 - - JJ cord-010119-t1x9gknd 2149 12 thaw thaw JJ cord-010119-t1x9gknd 2149 13 recoveries recovery NNS cord-010119-t1x9gknd 2149 14 of of IN cord-010119-t1x9gknd 2149 15 viable viable JJ cord-010119-t1x9gknd 2149 16 cells cell NNS cord-010119-t1x9gknd 2149 17 are be VBP cord-010119-t1x9gknd 2149 18 markedly markedly RB cord-010119-t1x9gknd 2149 19 increased increase VBN cord-010119-t1x9gknd 2149 20 , , , cord-010119-t1x9gknd 2149 21 with with IN cord-010119-t1x9gknd 2149 22 a a DT cord-010119-t1x9gknd 2149 23 yield yield NN cord-010119-t1x9gknd 2149 24 of of IN cord-010119-t1x9gknd 2149 25 approximately approximately RB cord-010119-t1x9gknd 2149 26 65 65 CD cord-010119-t1x9gknd 2149 27 % % NN cord-010119-t1x9gknd 2149 28 of of IN cord-010119-t1x9gknd 2149 29 the the DT cord-010119-t1x9gknd 2149 30 CD341 CD341 NNP cord-010119-t1x9gknd 2149 31 fraction fraction NN cord-010119-t1x9gknd 2149 32 post post NN cord-010119-t1x9gknd 2149 33 separation separation NN cord-010119-t1x9gknd 2149 34 and and CC cord-010119-t1x9gknd 2149 35 freeze freeze NN cord-010119-t1x9gknd 2149 36 thaw thaw NN cord-010119-t1x9gknd 2149 37 ( ( -LRB- cord-010119-t1x9gknd 2149 38 Table table NN cord-010119-t1x9gknd 2149 39 1 1 CD cord-010119-t1x9gknd 2149 40 ) ) -RRB- cord-010119-t1x9gknd 2149 41 . . . cord-010119-t1x9gknd 2150 1 Possibly possibly RB cord-010119-t1x9gknd 2150 2 more more RBR cord-010119-t1x9gknd 2150 3 important important JJ cord-010119-t1x9gknd 2150 4 , , , cord-010119-t1x9gknd 2150 5 the the DT cord-010119-t1x9gknd 2150 6 CFU CFU NNP cord-010119-t1x9gknd 2150 7 assay assay NN cord-010119-t1x9gknd 2150 8 results result NNS cord-010119-t1x9gknd 2150 9 reproducibly reproducibly RB cord-010119-t1x9gknd 2150 10 yield yield VBP cord-010119-t1x9gknd 2150 11 higher high JJR cord-010119-t1x9gknd 2150 12 counts count NNS cord-010119-t1x9gknd 2150 13 of of IN cord-010119-t1x9gknd 2150 14 CFU CFU NNP cord-010119-t1x9gknd 2150 15 - - HYPH cord-010119-t1x9gknd 2150 16 GM GM NNP cord-010119-t1x9gknd 2150 17 , , , cord-010119-t1x9gknd 2150 18 CFU CFU NNP cord-010119-t1x9gknd 2150 19 - - HYPH cord-010119-t1x9gknd 2150 20 GEMM GEMM NNP cord-010119-t1x9gknd 2150 21 and and CC cord-010119-t1x9gknd 2150 22 BFU BFU NNP cord-010119-t1x9gknd 2150 23 colonies colony NNS cord-010119-t1x9gknd 2150 24 ( ( -LRB- cord-010119-t1x9gknd 2150 25 Table table NN cord-010119-t1x9gknd 2150 26 _SP cord-010119-t1x9gknd 2150 27 1 1 CD cord-010119-t1x9gknd 2150 28 ) ) -RRB- cord-010119-t1x9gknd 2150 29 which which WDT cord-010119-t1x9gknd 2150 30 is be VBZ cord-010119-t1x9gknd 2150 31 a a DT cord-010119-t1x9gknd 2150 32 strong strong JJ cord-010119-t1x9gknd 2150 33 indicator indicator NN cord-010119-t1x9gknd 2150 34 that that IN cord-010119-t1x9gknd 2150 35 this this DT cord-010119-t1x9gknd 2150 36 method method NN cord-010119-t1x9gknd 2150 37 will will MD cord-010119-t1x9gknd 2150 38 improve improve VB cord-010119-t1x9gknd 2150 39 patient patient JJ cord-010119-t1x9gknd 2150 40 outcomes outcome NNS cord-010119-t1x9gknd 2150 41 . . . cord-010119-t1x9gknd 2151 1 In in IN cord-010119-t1x9gknd 2151 2 addition addition NN cord-010119-t1x9gknd 2151 3 , , , cord-010119-t1x9gknd 2151 4 our -PRON- PRP$ cord-010119-t1x9gknd 2151 5 separation separation NN cord-010119-t1x9gknd 2151 6 method method NN cord-010119-t1x9gknd 2151 7 isolates isolate VBZ cord-010119-t1x9gknd 2151 8 and and CC cord-010119-t1x9gknd 2151 9 preserves preserve VBZ cord-010119-t1x9gknd 2151 10 the the DT cord-010119-t1x9gknd 2151 11 megakaryocyte megakaryocyte NNP cord-010119-t1x9gknd 2151 12 - - HYPH cord-010119-t1x9gknd 2151 13 like like JJ cord-010119-t1x9gknd 2151 14 cells cell NNS cord-010119-t1x9gknd 2151 15 ( ( -LRB- cord-010119-t1x9gknd 2151 16 CD451CD611 CD451CD611 NNP cord-010119-t1x9gknd 2151 17 ) ) -RRB- cord-010119-t1x9gknd 2151 18 and and CC cord-010119-t1x9gknd 2151 19 early early JJ cord-010119-t1x9gknd 2151 20 projenitor projenitor NN cord-010119-t1x9gknd 2151 21 cells cell NNS cord-010119-t1x9gknd 2151 22 expressing express VBG cord-010119-t1x9gknd 2151 23 Oct4 Oct4 NNP cord-010119-t1x9gknd 2151 24 and and CC cord-010119-t1x9gknd 2151 25 Nanog Nanog NNP cord-010119-t1x9gknd 2151 26 ( ( -LRB- cord-010119-t1x9gknd 2151 27 markers marker NNS cord-010119-t1x9gknd 2151 28 for for IN cord-010119-t1x9gknd 2151 29 VSELs vsel NNS cord-010119-t1x9gknd 2151 30 ) ) -RRB- cord-010119-t1x9gknd 2151 31 which which WDT cord-010119-t1x9gknd 2151 32 are be VBP cord-010119-t1x9gknd 2151 33 two two CD cord-010119-t1x9gknd 2151 34 examples example NNS cord-010119-t1x9gknd 2151 35 of of IN cord-010119-t1x9gknd 2151 36 cellular cellular JJ cord-010119-t1x9gknd 2151 37 subsets subset NNS cord-010119-t1x9gknd 2151 38 usually usually RB cord-010119-t1x9gknd 2151 39 lost lose VBN cord-010119-t1x9gknd 2151 40 using use VBG cord-010119-t1x9gknd 2151 41 current current JJ cord-010119-t1x9gknd 2151 42 separation separation NN cord-010119-t1x9gknd 2151 43 techniques technique NNS cord-010119-t1x9gknd 2151 44 . . . cord-010119-t1x9gknd 2152 1 Conclusion conclusion NN cord-010119-t1x9gknd 2152 2 : : : cord-010119-t1x9gknd 2153 1 These these DT cord-010119-t1x9gknd 2153 2 results result NNS cord-010119-t1x9gknd 2153 3 demonstrate demonstrate VBP cord-010119-t1x9gknd 2153 4 that that IN cord-010119-t1x9gknd 2153 5 our -PRON- PRP$ cord-010119-t1x9gknd 2153 6 method method NN cord-010119-t1x9gknd 2153 7 achieves achieve VBZ cord-010119-t1x9gknd 2153 8 : : : cord-010119-t1x9gknd 2154 1 1 1 LS cord-010119-t1x9gknd 2154 2 . . . cord-010119-t1x9gknd 2155 1 Routine routine JJ cord-010119-t1x9gknd 2155 2 recovery recovery NN cord-010119-t1x9gknd 2155 3 of of IN cord-010119-t1x9gknd 2155 4 the the DT cord-010119-t1x9gknd 2155 5 WCF WCF NNP cord-010119-t1x9gknd 2155 6 at at IN cord-010119-t1x9gknd 2155 7 levels level NNS cord-010119-t1x9gknd 2155 8 higher high JJR cord-010119-t1x9gknd 2155 9 than than IN cord-010119-t1x9gknd 2155 10 current current JJ cord-010119-t1x9gknd 2155 11 methods method NNS cord-010119-t1x9gknd 2155 12 , , , cord-010119-t1x9gknd 2155 13 independent independent JJ cord-010119-t1x9gknd 2155 14 of of IN cord-010119-t1x9gknd 2155 15 volume volume NN cord-010119-t1x9gknd 2155 16 . . . cord-010119-t1x9gknd 2156 1 2 2 LS cord-010119-t1x9gknd 2156 2 . . . cord-010119-t1x9gknd 2157 1 Higher high JJR cord-010119-t1x9gknd 2157 2 percentage percentage NN cord-010119-t1x9gknd 2157 3 recoveries recovery NNS cord-010119-t1x9gknd 2157 4 of of IN cord-010119-t1x9gknd 2157 5 all all DT cord-010119-t1x9gknd 2157 6 cell cell NN cord-010119-t1x9gknd 2157 7 types type NNS cord-010119-t1x9gknd 2157 8 tested test VBN cord-010119-t1x9gknd 2157 9 than than IN cord-010119-t1x9gknd 2157 10 can can MD cord-010119-t1x9gknd 2157 11 be be VB cord-010119-t1x9gknd 2157 12 achieved achieve VBN cord-010119-t1x9gknd 2157 13 with with IN cord-010119-t1x9gknd 2157 14 existing exist VBG cord-010119-t1x9gknd 2157 15 methods method NNS cord-010119-t1x9gknd 2157 16 . . . cord-010119-t1x9gknd 2158 1 3 3 LS cord-010119-t1x9gknd 2158 2 . . . cord-010119-t1x9gknd 2159 1 Markedly markedly RB cord-010119-t1x9gknd 2159 2 higher high JJR cord-010119-t1x9gknd 2159 3 post post JJ cord-010119-t1x9gknd 2159 4 - - JJ cord-010119-t1x9gknd 2159 5 thaw thaw JJ cord-010119-t1x9gknd 2159 6 recovery recovery NN cord-010119-t1x9gknd 2159 7 of of IN cord-010119-t1x9gknd 2159 8 viable viable JJ cord-010119-t1x9gknd 2159 9 nucleated nucleated JJ cord-010119-t1x9gknd 2159 10 cells cell NNS cord-010119-t1x9gknd 2159 11 than than IN cord-010119-t1x9gknd 2159 12 any any DT cord-010119-t1x9gknd 2159 13 current current JJ cord-010119-t1x9gknd 2159 14 methodology methodology NN cord-010119-t1x9gknd 2159 15 . . . cord-010119-t1x9gknd 2160 1 4 4 LS cord-010119-t1x9gknd 2160 2 . . . cord-010119-t1x9gknd 2161 1 Almost almost RB cord-010119-t1x9gknd 2161 2 complete complete JJ cord-010119-t1x9gknd 2161 3 removal removal NN cord-010119-t1x9gknd 2161 4 of of IN cord-010119-t1x9gknd 2161 5 hematocrit hematocrit NN cord-010119-t1x9gknd 2161 6 . . . cord-010119-t1x9gknd 2162 1 As as IN cord-010119-t1x9gknd 2162 2 a a DT cord-010119-t1x9gknd 2162 3 result result NN cord-010119-t1x9gknd 2162 4 units unit NNS cord-010119-t1x9gknd 2162 5 of of IN cord-010119-t1x9gknd 2162 6 cord cord NN cord-010119-t1x9gknd 2162 7 blood blood NN cord-010119-t1x9gknd 2162 8 separated separate VBD cord-010119-t1x9gknd 2162 9 using use VBG cord-010119-t1x9gknd 2162 10 this this DT cord-010119-t1x9gknd 2162 11 new new JJ cord-010119-t1x9gknd 2162 12 method method NN cord-010119-t1x9gknd 2162 13 will will MD cord-010119-t1x9gknd 2162 14 contain contain VB cord-010119-t1x9gknd 2162 15 cell cell NN cord-010119-t1x9gknd 2162 16 yields yield NNS cord-010119-t1x9gknd 2162 17 that that WDT cord-010119-t1x9gknd 2162 18 could could MD cord-010119-t1x9gknd 2162 19 only only RB cord-010119-t1x9gknd 2162 20 otherwise otherwise RB cord-010119-t1x9gknd 2162 21 be be VB cord-010119-t1x9gknd 2162 22 achieved achieve VBN cord-010119-t1x9gknd 2162 23 through through IN cord-010119-t1x9gknd 2162 24 pooling pool VBG cord-010119-t1x9gknd 2162 25 multiple multiple JJ cord-010119-t1x9gknd 2162 26 separate separate JJ cord-010119-t1x9gknd 2162 27 units unit NNS cord-010119-t1x9gknd 2162 28 . . . cord-010119-t1x9gknd 2163 1 Therefore therefore RB cord-010119-t1x9gknd 2163 2 , , , cord-010119-t1x9gknd 2163 3 this this DT cord-010119-t1x9gknd 2163 4 new new JJ cord-010119-t1x9gknd 2163 5 method method NN cord-010119-t1x9gknd 2163 6 has have VBZ cord-010119-t1x9gknd 2163 7 the the DT cord-010119-t1x9gknd 2163 8 potential potential NN cord-010119-t1x9gknd 2163 9 to to TO cord-010119-t1x9gknd 2163 10 increase increase VB cord-010119-t1x9gknd 2163 11 the the DT cord-010119-t1x9gknd 2163 12 demand demand NN cord-010119-t1x9gknd 2163 13 for for IN cord-010119-t1x9gknd 2163 14 cord cord NN cord-010119-t1x9gknd 2163 15 blood blood NN cord-010119-t1x9gknd 2163 16 in in IN cord-010119-t1x9gknd 2163 17 therapy therapy NN cord-010119-t1x9gknd 2163 18 , , , cord-010119-t1x9gknd 2163 19 expanding expand VBG cord-010119-t1x9gknd 2163 20 to to IN cord-010119-t1x9gknd 2163 21 larger large JJR cord-010119-t1x9gknd 2163 22 individuals individual NNS cord-010119-t1x9gknd 2163 23 and and CC cord-010119-t1x9gknd 2163 24 adults adult NNS cord-010119-t1x9gknd 2163 25 , , , cord-010119-t1x9gknd 2163 26 where where WRB cord-010119-t1x9gknd 2163 27 up up IN cord-010119-t1x9gknd 2163 28 until until IN cord-010119-t1x9gknd 2163 29 now now RB cord-010119-t1x9gknd 2163 30 , , , cord-010119-t1x9gknd 2163 31 it -PRON- PRP cord-010119-t1x9gknd 2163 32 has have VBZ cord-010119-t1x9gknd 2163 33 been be VBN cord-010119-t1x9gknd 2163 34 suppressed suppress VBN cord-010119-t1x9gknd 2163 35 due due IN cord-010119-t1x9gknd 2163 36 to to IN cord-010119-t1x9gknd 2163 37 limited limited JJ cord-010119-t1x9gknd 2163 38 cell cell NN cord-010119-t1x9gknd 2163 39 yields yield NNS cord-010119-t1x9gknd 2163 40 delivered deliver VBN cord-010119-t1x9gknd 2163 41 by by IN cord-010119-t1x9gknd 2163 42 existing exist VBG cord-010119-t1x9gknd 2163 43 methods method NNS cord-010119-t1x9gknd 2163 44 . . . cord-010119-t1x9gknd 2164 1 Effects effect NNS cord-010119-t1x9gknd 2164 2 of of IN cord-010119-t1x9gknd 2164 3 Implementation implementation NN cord-010119-t1x9gknd 2164 4 of of IN cord-010119-t1x9gknd 2164 5 an an DT cord-010119-t1x9gknd 2164 6 Absolute Absolute NNP cord-010119-t1x9gknd 2164 7 Lymphocyte Lymphocyte NNP cord-010119-t1x9gknd 2164 8 Count Count NNP cord-010119-t1x9gknd 2164 9 Target Target NNP cord-010119-t1x9gknd 2164 10 , , , cord-010119-t1x9gknd 2164 11 in in IN cord-010119-t1x9gknd 2164 12 Addition addition NN cord-010119-t1x9gknd 2164 13 to to IN cord-010119-t1x9gknd 2164 14 CD341 CD341 NNP cord-010119-t1x9gknd 2164 15 Target Target NNP cord-010119-t1x9gknd 2164 16 , , , cord-010119-t1x9gknd 2164 17 for for IN cord-010119-t1x9gknd 2164 18 Hematopoietic Hematopoietic NNP cord-010119-t1x9gknd 2164 19 Progenitor Progenitor NNP cord-010119-t1x9gknd 2164 20 Cell Cell NNP cord-010119-t1x9gknd 2164 21 Collection Collection NNP cord-010119-t1x9gknd 2165 1 Edwin Edwin NNP cord-010119-t1x9gknd 2165 2 A a DT cord-010119-t1x9gknd 2165 3 Burgstaler Burgstaler NNP cord-010119-t1x9gknd 2165 4 * * NFP cord-010119-t1x9gknd 2165 5 , , , cord-010119-t1x9gknd 2165 6 Luis Luis NNP cord-010119-t1x9gknd 2165 7 F F NNP cord-010119-t1x9gknd 2165 8 Porrata Porrata NNP cord-010119-t1x9gknd 2165 9 , , , cord-010119-t1x9gknd 2165 10 Dennis Dennis NNP cord-010119-t1x9gknd 2165 11 A A NNP cord-010119-t1x9gknd 2165 12 Gastineau Gastineau NNP cord-010119-t1x9gknd 2165 13 , , , cord-010119-t1x9gknd 2165 14 Eapen Eapen NNP cord-010119-t1x9gknd 2165 15 K K NNP cord-010119-t1x9gknd 2165 16 Jacob Jacob NNP cord-010119-t1x9gknd 2165 17 and and CC cord-010119-t1x9gknd 2165 18 Jeffrey Jeffrey NNP cord-010119-t1x9gknd 2165 19 L L NNP cord-010119-t1x9gknd 2165 20 Winters Winters NNP cord-010119-t1x9gknd 2165 21 . . . cord-010119-t1x9gknd 2166 1 Mayo Mayo NNP cord-010119-t1x9gknd 2166 2 Clinic Clinic NNP cord-010119-t1x9gknd 2166 3 Background Background NNP cord-010119-t1x9gknd 2166 4 / / SYM cord-010119-t1x9gknd 2166 5 Case Case NNP cord-010119-t1x9gknd 2166 6 Studies Studies NNPS cord-010119-t1x9gknd 2166 7 : : : cord-010119-t1x9gknd 2166 8 Lymphoma lymphoma NN cord-010119-t1x9gknd 2166 9 patients patient NNS cord-010119-t1x9gknd 2166 10 receiving receive VBG cord-010119-t1x9gknd 2166 11 > > XX cord-010119-t1x9gknd 2166 12 0.5x10 0.5x10 CD cord-010119-t1x9gknd 2166 13 9 9 CD cord-010119-t1x9gknd 2166 14 lymphocytes(lymph)/Kg lymphocytes(lymph)/kg NN cord-010119-t1x9gknd 2167 1 during during IN cord-010119-t1x9gknd 2167 2 peripheral peripheral JJ cord-010119-t1x9gknd 2167 3 blood blood NN cord-010119-t1x9gknd 2167 4 stem stem NN cord-010119-t1x9gknd 2167 5 cell cell NN cord-010119-t1x9gknd 2167 6 transplant transplant NN cord-010119-t1x9gknd 2167 7 have have VBP cord-010119-t1x9gknd 2167 8 superior superior JJ cord-010119-t1x9gknd 2167 9 survival survival NN cord-010119-t1x9gknd 2167 10 . . . cord-010119-t1x9gknd 2168 1 In in IN cord-010119-t1x9gknd 2168 2 addition addition NN cord-010119-t1x9gknd 2168 3 to to IN cord-010119-t1x9gknd 2168 4 a a DT cord-010119-t1x9gknd 2168 5 CD341 cd341 NN cord-010119-t1x9gknd 2168 6 cell cell NN cord-010119-t1x9gknd 2168 7 target target NN cord-010119-t1x9gknd 2168 8 of of IN cord-010119-t1x9gknd 2168 9 4.0x10 4.0x10 CD cord-010119-t1x9gknd 2168 10 6 6 CD cord-010119-t1x9gknd 2168 11 /Kg /kg NN cord-010119-t1x9gknd 2168 12 , , , cord-010119-t1x9gknd 2168 13 a a DT cord-010119-t1x9gknd 2168 14 lymph lymph NN cord-010119-t1x9gknd 2168 15 target target NN cord-010119-t1x9gknd 2168 16 was be VBD cord-010119-t1x9gknd 2168 17 also also RB cord-010119-t1x9gknd 2168 18 implemented implement VBN cord-010119-t1x9gknd 2168 19 . . . cord-010119-t1x9gknd 2169 1 Fifty fifty CD cord-010119-t1x9gknd 2169 2 patients patient NNS cord-010119-t1x9gknd 2169 3 before before IN cord-010119-t1x9gknd 2169 4 ( ( -LRB- cord-010119-t1x9gknd 2169 5 No no DT cord-010119-t1x9gknd 2169 6 ALC ALC NNP cord-010119-t1x9gknd 2169 7 ) ) -RRB- cord-010119-t1x9gknd 2169 8 and and CC cord-010119-t1x9gknd 2169 9 after after IN cord-010119-t1x9gknd 2169 10 ( ( -LRB- cord-010119-t1x9gknd 2169 11 ALC ALC NNP cord-010119-t1x9gknd 2169 12 ) ) -RRB- cord-010119-t1x9gknd 2169 13 implementation implementation NN cord-010119-t1x9gknd 2169 14 were be VBD cord-010119-t1x9gknd 2169 15 retrospectively retrospectively RB cord-010119-t1x9gknd 2169 16 evaluated evaluate VBN cord-010119-t1x9gknd 2169 17 . . . cord-010119-t1x9gknd 2170 1 Study Study NNP cord-010119-t1x9gknd 2170 2 Design Design NNP cord-010119-t1x9gknd 2170 3 / / SYM cord-010119-t1x9gknd 2170 4 Method method NN cord-010119-t1x9gknd 2170 5 : : : cord-010119-t1x9gknd 2170 6 Lymph lymph NN cord-010119-t1x9gknd 2170 7 and and CC cord-010119-t1x9gknd 2170 8 CD341 cd341 NN cord-010119-t1x9gknd 2170 9 yields yield NNS cord-010119-t1x9gknd 2170 10 , , , cord-010119-t1x9gknd 2170 11 number number NN cord-010119-t1x9gknd 2170 12 of of IN cord-010119-t1x9gknd 2170 13 collections collection NNS cord-010119-t1x9gknd 2170 14 , , , cord-010119-t1x9gknd 2170 15 lymph lymph NN cord-010119-t1x9gknd 2170 16 target target NN cord-010119-t1x9gknd 2170 17 reached reach VBN cord-010119-t1x9gknd 2170 18 , , , cord-010119-t1x9gknd 2170 19 and and CC cord-010119-t1x9gknd 2170 20 days day NNS cord-010119-t1x9gknd 2170 21 to to IN cord-010119-t1x9gknd 2170 22 engraftment engraftment NNP cord-010119-t1x9gknd 2170 23 were be VBD cord-010119-t1x9gknd 2170 24 examined examine VBN cord-010119-t1x9gknd 2170 25 . . . cord-010119-t1x9gknd 2171 1 Mobilization mobilization NN cord-010119-t1x9gknd 2171 2 was be VBD cord-010119-t1x9gknd 2171 3 G G NNP cord-010119-t1x9gknd 2171 4 - - HYPH cord-010119-t1x9gknd 2171 5 CSF CSF NNP cord-010119-t1x9gknd 2171 6 ( ( -LRB- cord-010119-t1x9gknd 2171 7 G G NNP cord-010119-t1x9gknd 2171 8 ) ) -RRB- cord-010119-t1x9gknd 2171 9 or or CC cord-010119-t1x9gknd 2171 10 G G NNP cord-010119-t1x9gknd 2171 11 - - HYPH cord-010119-t1x9gknd 2171 12 CSF CSF NNP cord-010119-t1x9gknd 2171 13 1 1 CD cord-010119-t1x9gknd 2171 14 plerixafor plerixafor NN cord-010119-t1x9gknd 2171 15 ( ( -LRB- cord-010119-t1x9gknd 2171 16 G1Pl g1pl CD cord-010119-t1x9gknd 2171 17 ) ) -RRB- cord-010119-t1x9gknd 2171 18 . . . cord-010119-t1x9gknd 2172 1 Consecutive consecutive JJ cord-010119-t1x9gknd 2172 2 No no DT cord-010119-t1x9gknd 2172 3 ALC alc NN cord-010119-t1x9gknd 2172 4 and and CC cord-010119-t1x9gknd 2172 5 ALC ALC NNP cord-010119-t1x9gknd 2172 6 procedures procedure NNS cord-010119-t1x9gknd 2172 7 were be VBD cord-010119-t1x9gknd 2172 8 examined examine VBN cord-010119-t1x9gknd 2172 9 . . . cord-010119-t1x9gknd 2173 1 The the DT cord-010119-t1x9gknd 2173 2 Mann Mann NNP cord-010119-t1x9gknd 2173 3 - - HYPH cord-010119-t1x9gknd 2173 4 Whitney Whitney NNP cord-010119-t1x9gknd 2173 5 and and CC cord-010119-t1x9gknd 2173 6 Chi Chi NNP cord-010119-t1x9gknd 2173 7 Square Square NNP cord-010119-t1x9gknd 2173 8 tests test NNS cord-010119-t1x9gknd 2173 9 were be VBD cord-010119-t1x9gknd 2173 10 used use VBN cord-010119-t1x9gknd 2173 11 for for IN cord-010119-t1x9gknd 2173 12 statistical statistical JJ cord-010119-t1x9gknd 2173 13 comparison comparison NN cord-010119-t1x9gknd 2173 14 , , , cord-010119-t1x9gknd 2173 15 p p NN cord-010119-t1x9gknd 2173 16 < < XX cord-010119-t1x9gknd 2173 17 0.05 0.05 CD cord-010119-t1x9gknd 2173 18 considered consider VBN cord-010119-t1x9gknd 2173 19 significant significant JJ cord-010119-t1x9gknd 2173 20 . . . cord-010119-t1x9gknd 2174 1 Results result NNS cord-010119-t1x9gknd 2175 1 /Finding /finde VBG cord-010119-t1x9gknd 2175 2 : : : cord-010119-t1x9gknd 2176 1 110 110 CD cord-010119-t1x9gknd 2176 2 No no DT cord-010119-t1x9gknd 2176 3 ALC alc NN cord-010119-t1x9gknd 2176 4 and and CC cord-010119-t1x9gknd 2176 5 159 159 CD cord-010119-t1x9gknd 2176 6 ALC ALC NNP cord-010119-t1x9gknd 2176 7 collections collection NNS cord-010119-t1x9gknd 2176 8 occurred occur VBD cord-010119-t1x9gknd 2176 9 among among IN cord-010119-t1x9gknd 2176 10 the the DT cord-010119-t1x9gknd 2176 11 50 50 CD cord-010119-t1x9gknd 2176 12 patients patient NNS cord-010119-t1x9gknd 2176 13 . . . cord-010119-t1x9gknd 2177 1 Fenwal Fenwal NNP cord-010119-t1x9gknd 2177 2 Amicus Amicus NNP cord-010119-t1x9gknd 2177 3 was be VBD cord-010119-t1x9gknd 2177 4 used use VBN cord-010119-t1x9gknd 2177 5 for for IN cord-010119-t1x9gknd 2177 6 91 91 CD cord-010119-t1x9gknd 2177 7 % % NN cord-010119-t1x9gknd 2177 8 of of IN cord-010119-t1x9gknd 2177 9 the the DT cord-010119-t1x9gknd 2177 10 No no DT cord-010119-t1x9gknd 2177 11 ALC ALC NNP cord-010119-t1x9gknd 2177 12 and and CC cord-010119-t1x9gknd 2177 13 99 99 CD cord-010119-t1x9gknd 2177 14 % % NN cord-010119-t1x9gknd 2177 15 of of IN cord-010119-t1x9gknd 2177 16 the the DT cord-010119-t1x9gknd 2177 17 ALC ALC NNP cord-010119-t1x9gknd 2177 18 collections collection NNS cord-010119-t1x9gknd 2177 19 ( ( -LRB- cord-010119-t1x9gknd 2177 20 TerumoBCT TerumoBCT NNP cord-010119-t1x9gknd 2177 21 Spectra Spectra NNP cord-010119-t1x9gknd 2177 22 Optia Optia NNP cord-010119-t1x9gknd 2177 23 CMNC CMNC NNP cord-010119-t1x9gknd 2177 24 used use VBD cord-010119-t1x9gknd 2177 25 for for IN cord-010119-t1x9gknd 2177 26 remaining remain VBG cord-010119-t1x9gknd 2177 27 ) ) -RRB- cord-010119-t1x9gknd 2177 28 . . . cord-010119-t1x9gknd 2178 1 Diagnosis diagnosis NN cord-010119-t1x9gknd 2178 2 was be VBD cord-010119-t1x9gknd 2178 3 5 5 CD cord-010119-t1x9gknd 2178 4 Hodgkin Hodgkin NNP cord-010119-t1x9gknd 2178 5 's 's POS cord-010119-t1x9gknd 2178 6 and and CC cord-010119-t1x9gknd 2178 7 45 45 CD cord-010119-t1x9gknd 2178 8 non non JJ cord-010119-t1x9gknd 2178 9 - - NNP cord-010119-t1x9gknd 2178 10 Hodgkin Hodgkin NNP cord-010119-t1x9gknd 2178 11 's 's POS cord-010119-t1x9gknd 2178 12 lymphoma lymphoma NN cord-010119-t1x9gknd 2178 13 ( ( -LRB- cord-010119-t1x9gknd 2178 14 No no DT cord-010119-t1x9gknd 2178 15 ALC ALC NNP cord-010119-t1x9gknd 2178 16 ) ) -RRB- cord-010119-t1x9gknd 2178 17 ; ; : cord-010119-t1x9gknd 2178 18 7 7 CD cord-010119-t1x9gknd 2178 19 Hodgkin Hodgkin NNP cord-010119-t1x9gknd 2178 20 's 's POS cord-010119-t1x9gknd 2178 21 and and CC cord-010119-t1x9gknd 2178 22 43 43 CD cord-010119-t1x9gknd 2178 23 non non JJ cord-010119-t1x9gknd 2178 24 - - NNP cord-010119-t1x9gknd 2178 25 Hodgkin Hodgkin NNP cord-010119-t1x9gknd 2178 26 's 's POS cord-010119-t1x9gknd 2178 27 lymphoma lymphoma NN cord-010119-t1x9gknd 2178 28 ( ( -LRB- cord-010119-t1x9gknd 2178 29 ALC ALC NNP cord-010119-t1x9gknd 2178 30 ) ) -RRB- cord-010119-t1x9gknd 2178 31 . . . cord-010119-t1x9gknd 2179 1 Pre pre JJ cord-010119-t1x9gknd 2179 2 procedure procedure NN cord-010119-t1x9gknd 2179 3 WBC WBC NNP cord-010119-t1x9gknd 2179 4 and and CC cord-010119-t1x9gknd 2179 5 lymph lymph NN cord-010119-t1x9gknd 2179 6 counts count NNS cord-010119-t1x9gknd 2179 7 were be VBD cord-010119-t1x9gknd 2179 8 significantly significantly RB cord-010119-t1x9gknd 2179 9 higher high JJR cord-010119-t1x9gknd 2179 10 for for IN cord-010119-t1x9gknd 2179 11 No no DT cord-010119-t1x9gknd 2179 12 ALC ALC NNP cord-010119-t1x9gknd 2179 13 ( ( -LRB- cord-010119-t1x9gknd 2179 14 WBC WBC NNP cord-010119-t1x9gknd 2179 15 49.3 49.3 CD cord-010119-t1x9gknd 2179 16 , , , cord-010119-t1x9gknd 2179 17 Lymph lymph NN cord-010119-t1x9gknd 2179 18 2.0x10 2.0x10 CD cord-010119-t1x9gknd 2179 19 9 9 CD cord-010119-t1x9gknd 2179 20 /L /L . cord-010119-t1x9gknd 2179 21 ) ) -RRB- cord-010119-t1x9gknd 2179 22 than than IN cord-010119-t1x9gknd 2179 23 ALC ALC NNP cord-010119-t1x9gknd 2179 24 ( ( -LRB- cord-010119-t1x9gknd 2179 25 WBC WBC NNP cord-010119-t1x9gknd 2179 26 39.1 39.1 CD cord-010119-t1x9gknd 2179 27 , , , cord-010119-t1x9gknd 2179 28 Lymph lymph NN cord-010119-t1x9gknd 2179 29 1.2x10 1.2x10 CD cord-010119-t1x9gknd 2179 30 9 9 CD cord-010119-t1x9gknd 2179 31 /L /L . cord-010119-t1x9gknd 2179 32 ) ) -RRB- cord-010119-t1x9gknd 2179 33 . . . cord-010119-t1x9gknd 2180 1 Equivalent equivalent JJ cord-010119-t1x9gknd 2180 2 whole whole JJ cord-010119-t1x9gknd 2180 3 blood blood NN cord-010119-t1x9gknd 2180 4 ( ( -LRB- cord-010119-t1x9gknd 2180 5 corrected correct VBN cord-010119-t1x9gknd 2180 6 for for IN cord-010119-t1x9gknd 2180 7 AC AC NNP cord-010119-t1x9gknd 2180 8 ) ) -RRB- cord-010119-t1x9gknd 2180 9 was be VBD cord-010119-t1x9gknd 2180 10 processed process VBN cord-010119-t1x9gknd 2180 11 for for IN cord-010119-t1x9gknd 2180 12 No no DT cord-010119-t1x9gknd 2180 13 ALC ALC NNP cord-010119-t1x9gknd 2180 14 ( ( -LRB- cord-010119-t1x9gknd 2180 15 16.4L 16.4l CD cord-010119-t1x9gknd 2180 16 ) ) -RRB- cord-010119-t1x9gknd 2180 17 and and CC cord-010119-t1x9gknd 2180 18 ALC ALC NNP cord-010119-t1x9gknd 2180 19 ( ( -LRB- cord-010119-t1x9gknd 2180 20 17.1L 17.1l CD cord-010119-t1x9gknd 2180 21 ) ) -RRB- cord-010119-t1x9gknd 2180 22 . . . cord-010119-t1x9gknd 2181 1 For for IN cord-010119-t1x9gknd 2181 2 ALC ALC NNP cord-010119-t1x9gknd 2181 3 group group NN cord-010119-t1x9gknd 2181 4 , , , cord-010119-t1x9gknd 2181 5 extra extra JJ cord-010119-t1x9gknd 2181 6 collections collection NNS cord-010119-t1x9gknd 2181 7 beyond beyond IN cord-010119-t1x9gknd 2181 8 CD341 cd341 NN cord-010119-t1x9gknd 2181 9 target target NN cord-010119-t1x9gknd 2181 10 were be VBD cord-010119-t1x9gknd 2181 11 : : : cord-010119-t1x9gknd 2181 12 0 0 CD cord-010119-t1x9gknd 2181 13 days day NNS cord-010119-t1x9gknd 2181 14 : : : cord-010119-t1x9gknd 2181 15 24 24 CD cord-010119-t1x9gknd 2181 16 % % NN cord-010119-t1x9gknd 2181 17 , , , cord-010119-t1x9gknd 2181 18 1 1 CD cord-010119-t1x9gknd 2181 19 day day NN cord-010119-t1x9gknd 2181 20 : : : cord-010119-t1x9gknd 2181 21 36 36 CD cord-010119-t1x9gknd 2181 22 % % NN cord-010119-t1x9gknd 2181 23 , , , cord-010119-t1x9gknd 2181 24 2 2 CD cord-010119-t1x9gknd 2181 25 days day NNS cord-010119-t1x9gknd 2181 26 : : : cord-010119-t1x9gknd 2181 27 22 22 CD cord-010119-t1x9gknd 2181 28 % % NN cord-010119-t1x9gknd 2181 29 , , , cord-010119-t1x9gknd 2181 30 3 3 CD cord-010119-t1x9gknd 2181 31 days day NNS cord-010119-t1x9gknd 2181 32 : : : cord-010119-t1x9gknd 2181 33 16 16 CD cord-010119-t1x9gknd 2181 34 % % NN cord-010119-t1x9gknd 2181 35 , , , cord-010119-t1x9gknd 2181 36 and and CC cord-010119-t1x9gknd 2181 37 5 5 CD cord-010119-t1x9gknd 2181 38 days day NNS cord-010119-t1x9gknd 2181 39 : : : cord-010119-t1x9gknd 2181 40 2 2 CD cord-010119-t1x9gknd 2181 41 % % NN cord-010119-t1x9gknd 2181 42 . . . cord-010119-t1x9gknd 2182 1 Significantly significantly RB cord-010119-t1x9gknd 2182 2 more more JJR cord-010119-t1x9gknd 2182 3 patients patient NNS cord-010119-t1x9gknd 2182 4 were be VBD cord-010119-t1x9gknd 2182 5 mobilized mobilize VBN cord-010119-t1x9gknd 2182 6 with with IN cord-010119-t1x9gknd 2182 7 G1Pl g1pl CD cord-010119-t1x9gknd 2182 8 in in IN cord-010119-t1x9gknd 2182 9 No no DT cord-010119-t1x9gknd 2182 10 ALC ALC NNP cord-010119-t1x9gknd 2182 11 group group NN cord-010119-t1x9gknd 2182 12 ( ( -LRB- cord-010119-t1x9gknd 2182 13 N581 n581 NN cord-010119-t1x9gknd 2182 14 ) ) -RRB- cord-010119-t1x9gknd 2182 15 than than IN cord-010119-t1x9gknd 2182 16 ALC ALC NNP cord-010119-t1x9gknd 2182 17 group group NN cord-010119-t1x9gknd 2182 18 ( ( -LRB- cord-010119-t1x9gknd 2182 19 N560 N560 NNP cord-010119-t1x9gknd 2182 20 ) ) -RRB- cord-010119-t1x9gknd 2182 21 and and CC cord-010119-t1x9gknd 2182 22 42 42 CD cord-010119-t1x9gknd 2182 23 collections collection NNS cord-010119-t1x9gknd 2182 24 in in IN cord-010119-t1x9gknd 2182 25 ALC ALC NNP cord-010119-t1x9gknd 2182 26 group group NN cord-010119-t1x9gknd 2182 27 had have VBD cord-010119-t1x9gknd 2182 28 mobilization mobilization NN cord-010119-t1x9gknd 2182 29 discontinued discontinue VBN cord-010119-t1x9gknd 2182 30 after after IN cord-010119-t1x9gknd 2182 31 CD341 cd341 NN cord-010119-t1x9gknd 2182 32 cell cell NN cord-010119-t1x9gknd 2182 33 target target NN cord-010119-t1x9gknd 2182 34 reached reach VBN cord-010119-t1x9gknd 2182 35 . . . cord-010119-t1x9gknd 2183 1 There there EX cord-010119-t1x9gknd 2183 2 was be VBD cord-010119-t1x9gknd 2183 3 no no DT cord-010119-t1x9gknd 2183 4 significant significant JJ cord-010119-t1x9gknd 2183 5 difference difference NN cord-010119-t1x9gknd 2183 6 in in IN cord-010119-t1x9gknd 2183 7 G g NN cord-010119-t1x9gknd 2183 8 ( ( -LRB- cord-010119-t1x9gknd 2183 9 13.2x10 13.2x10 CD cord-010119-t1x9gknd 2183 10 9 9 CD cord-010119-t1x9gknd 2183 11 lymph lymph NN cord-010119-t1x9gknd 2183 12 ) ) -RRB- cord-010119-t1x9gknd 2183 13 compared compare VBN cord-010119-t1x9gknd 2183 14 to to IN cord-010119-t1x9gknd 2183 15 G1Pl g1pl CD cord-010119-t1x9gknd 2183 16 mobilized mobilize VBN cord-010119-t1x9gknd 2183 17 collections collection NNS cord-010119-t1x9gknd 2183 18 ( ( -LRB- cord-010119-t1x9gknd 2183 19 13.0x10 13.0x10 CD cord-010119-t1x9gknd 2183 20 9 9 CD cord-010119-t1x9gknd 2183 21 lymph lymph NN cord-010119-t1x9gknd 2183 22 ) ) -RRB- cord-010119-t1x9gknd 2183 23 ; ; : cord-010119-t1x9gknd 2183 24 both both DT cord-010119-t1x9gknd 2183 25 were be VBD cord-010119-t1x9gknd 2183 26 significantly significantly RB cord-010119-t1x9gknd 2183 27 higher high JJR cord-010119-t1x9gknd 2183 28 than than IN cord-010119-t1x9gknd 2183 29 the the DT cord-010119-t1x9gknd 2183 30 collections collection NNS cord-010119-t1x9gknd 2183 31 where where WRB cord-010119-t1x9gknd 2183 32 mobilization mobilization NN cord-010119-t1x9gknd 2183 33 had have VBD cord-010119-t1x9gknd 2183 34 been be VBN cord-010119-t1x9gknd 2183 35 discontinued discontinue VBN cord-010119-t1x9gknd 2183 36 ( ( -LRB- cord-010119-t1x9gknd 2183 37 5.9 5.9 CD cord-010119-t1x9gknd 2183 38 x10 x10 CD cord-010119-t1x9gknd 2183 39 9 9 CD cord-010119-t1x9gknd 2183 40 lymph lymph NN cord-010119-t1x9gknd 2183 41 ) ) -RRB- cord-010119-t1x9gknd 2183 42 . . . cord-010119-t1x9gknd 2184 1 Days day NNS cord-010119-t1x9gknd 2184 2 to to IN cord-010119-t1x9gknd 2184 3 WBC WBC NNP cord-010119-t1x9gknd 2184 4 engraftment engraftment NNP cord-010119-t1x9gknd 2184 5 ( ( -LRB- cord-010119-t1x9gknd 2184 6 13.5 13.5 CD cord-010119-t1x9gknd 2184 7 No no DT cord-010119-t1x9gknd 2184 8 ALC alc NN cord-010119-t1x9gknd 2184 9 vs vs IN cord-010119-t1x9gknd 2184 10 13.0 13.0 CD cord-010119-t1x9gknd 2184 11 ALC ALC NNP cord-010119-t1x9gknd 2184 12 ) ) -RRB- cord-010119-t1x9gknd 2184 13 and and CC cord-010119-t1x9gknd 2184 14 platelet platelet NN cord-010119-t1x9gknd 2184 15 engraftment engraftment NN cord-010119-t1x9gknd 2184 16 ( ( -LRB- cord-010119-t1x9gknd 2184 17 13.0 13.0 CD cord-010119-t1x9gknd 2184 18 NO no DT cord-010119-t1x9gknd 2184 19 ALC alc NN cord-010119-t1x9gknd 2184 20 vs vs IN cord-010119-t1x9gknd 2184 21 12.0 12.0 CD cord-010119-t1x9gknd 2184 22 ALC ALC NNP cord-010119-t1x9gknd 2184 23 ) ) -RRB- cord-010119-t1x9gknd 2184 24 were be VBD cord-010119-t1x9gknd 2184 25 not not RB cord-010119-t1x9gknd 2184 26 significantly significantly RB cord-010119-t1x9gknd 2184 27 different different JJ cord-010119-t1x9gknd 2184 28 . . . cord-010119-t1x9gknd 2185 1 Median median JJ cord-010119-t1x9gknd 2185 2 number number NN cord-010119-t1x9gknd 2185 3 of of IN cord-010119-t1x9gknd 2185 4 collections collection NNS cord-010119-t1x9gknd 2185 5 for for IN cord-010119-t1x9gknd 2185 6 No no DT cord-010119-t1x9gknd 2185 7 ALC alc NN cord-010119-t1x9gknd 2185 8 ( ( -LRB- cord-010119-t1x9gknd 2185 9 2 2 CD cord-010119-t1x9gknd 2185 10 ) ) -RRB- cord-010119-t1x9gknd 2185 11 and and CC cord-010119-t1x9gknd 2185 12 ALC ALC NNP cord-010119-t1x9gknd 2185 13 ( ( -LRB- cord-010119-t1x9gknd 2185 14 3 3 CD cord-010119-t1x9gknd 2185 15 ) ) -RRB- cord-010119-t1x9gknd 2185 16 were be VBD cord-010119-t1x9gknd 2185 17 not not RB cord-010119-t1x9gknd 2185 18 significantly significantly RB cord-010119-t1x9gknd 2185 19 different different JJ cord-010119-t1x9gknd 2185 20 . . . cord-010119-t1x9gknd 2186 1 Data datum NNS cord-010119-t1x9gknd 2186 2 ( ( -LRB- cord-010119-t1x9gknd 2186 3 medians median NNS cord-010119-t1x9gknd 2186 4 ) ) -RRB- cord-010119-t1x9gknd 2186 5 in in IN cord-010119-t1x9gknd 2186 6 the the DT cord-010119-t1x9gknd 2186 7 table table NN cord-010119-t1x9gknd 2186 8 . . . cord-010119-t1x9gknd 2187 1 Conclusion conclusion NN cord-010119-t1x9gknd 2187 2 : : : cord-010119-t1x9gknd 2187 3 Not not RB cord-010119-t1x9gknd 2187 4 all all DT cord-010119-t1x9gknd 2187 5 patients patient NNS cord-010119-t1x9gknd 2187 6 achieved achieve VBD cord-010119-t1x9gknd 2187 7 the the DT cord-010119-t1x9gknd 2187 8 0.5x10 0.5x10 CD cord-010119-t1x9gknd 2187 9 9 9 CD cord-010119-t1x9gknd 2187 10 lymph lymph NN cord-010119-t1x9gknd 2187 11 / / , cord-010119-t1x9gknd 2187 12 Kg kg CD cord-010119-t1x9gknd 2187 13 or or CC cord-010119-t1x9gknd 2187 14 even even RB cord-010119-t1x9gknd 2187 15 the the DT cord-010119-t1x9gknd 2187 16 0.3x10 0.3x10 CD cord-010119-t1x9gknd 2187 17 9 9 CD cord-010119-t1x9gknd 2187 18 lymph lymph NN cord-010119-t1x9gknd 2187 19 / / , cord-010119-t1x9gknd 2187 20 Kg kg CD cord-010119-t1x9gknd 2187 21 targets target NNS cord-010119-t1x9gknd 2187 22 . . . cord-010119-t1x9gknd 2188 1 Implementation implementation NN cord-010119-t1x9gknd 2188 2 of of IN cord-010119-t1x9gknd 2188 3 a a DT cord-010119-t1x9gknd 2188 4 lymph lymph NN cord-010119-t1x9gknd 2188 5 target target NN cord-010119-t1x9gknd 2188 6 increased increase VBN cord-010119-t1x9gknd 2188 7 patients patient NNS cord-010119-t1x9gknd 2188 8 obtaining obtain VBG cord-010119-t1x9gknd 2188 9 0.5x10 0.5x10 CD cord-010119-t1x9gknd 2188 10 9 9 CD cord-010119-t1x9gknd 2188 11 lymph lymph NN cord-010119-t1x9gknd 2188 12 / / , cord-010119-t1x9gknd 2188 13 Kg kg CD cord-010119-t1x9gknd 2188 14 from from IN cord-010119-t1x9gknd 2188 15 40 40 CD cord-010119-t1x9gknd 2188 16 % % NN cord-010119-t1x9gknd 2188 17 to to IN cord-010119-t1x9gknd 2188 18 54 54 CD cord-010119-t1x9gknd 2188 19 % % NN cord-010119-t1x9gknd 2188 20 . . . cord-010119-t1x9gknd 2189 1 Only only RB cord-010119-t1x9gknd 2189 2 12 12 CD cord-010119-t1x9gknd 2189 3 % % NN cord-010119-t1x9gknd 2189 4 had have VBD cord-010119-t1x9gknd 2189 5 < < NNP cord-010119-t1x9gknd 2189 6 0.3x10 0.3x10 CD cord-010119-t1x9gknd 2189 7 9 9 CD cord-010119-t1x9gknd 2189 8 lymph/ lymph/ CD cord-010119-t1x9gknd 2189 9 Kg Kg NNP cord-010119-t1x9gknd 2189 10 . . . cord-010119-t1x9gknd 2190 1 Discontinuation discontinuation NN cord-010119-t1x9gknd 2190 2 of of IN cord-010119-t1x9gknd 2190 3 mobilization mobilization NN cord-010119-t1x9gknd 2190 4 once once RB cord-010119-t1x9gknd 2190 5 CD341 cd341 NN cord-010119-t1x9gknd 2190 6 cell cell NN cord-010119-t1x9gknd 2190 7 target target NN cord-010119-t1x9gknd 2190 8 was be VBD cord-010119-t1x9gknd 2190 9 reached reach VBN cord-010119-t1x9gknd 2190 10 significantly significantly RB cord-010119-t1x9gknd 2190 11 reduced reduce VBN cord-010119-t1x9gknd 2190 12 lymph lymph NN cord-010119-t1x9gknd 2190 13 yield yield NN cord-010119-t1x9gknd 2190 14 . . . cord-010119-t1x9gknd 2191 1 The the DT cord-010119-t1x9gknd 2191 2 median median JJ cord-010119-t1x9gknd 2191 3 increase increase NN cord-010119-t1x9gknd 2191 4 of of IN cord-010119-t1x9gknd 2191 5 one one CD cord-010119-t1x9gknd 2191 6 collection collection NN cord-010119-t1x9gknd 2191 7 per per IN cord-010119-t1x9gknd 2191 8 patient patient JJ cord-010119-t1x9gknd 2191 9 following follow VBG cord-010119-t1x9gknd 2191 10 implementation implementation NN cord-010119-t1x9gknd 2191 11 was be VBD cord-010119-t1x9gknd 2191 12 less less JJR cord-010119-t1x9gknd 2191 13 than than IN cord-010119-t1x9gknd 2191 14 had have VBD cord-010119-t1x9gknd 2191 15 been be VBN cord-010119-t1x9gknd 2191 16 expected expect VBN cord-010119-t1x9gknd 2191 17 . . . cord-010119-t1x9gknd 2192 1 Extended Extended NNP cord-010119-t1x9gknd 2192 2 Preprocessing Preprocessing NNP cord-010119-t1x9gknd 2192 3 Storage Storage NNP cord-010119-t1x9gknd 2192 4 Impairs Impairs NNP cord-010119-t1x9gknd 2192 5 Cord Cord NNP cord-010119-t1x9gknd 2192 6 Blood blood NN cord-010119-t1x9gknd 2192 7 Hematopoietic Hematopoietic NNP cord-010119-t1x9gknd 2192 8 Stem Stem NNP cord-010119-t1x9gknd 2192 9 Cell cell NN cord-010119-t1x9gknd 2192 10 Activity activity NN cord-010119-t1x9gknd 2192 11 Suria Suria NNP cord-010119-t1x9gknd 2192 12 Jahan Jahan NNP cord-010119-t1x9gknd 2193 1 * * NFP cord-010119-t1x9gknd 2193 2 1,2 1,2 CD cord-010119-t1x9gknd 2193 3 and and CC cord-010119-t1x9gknd 2193 4 Nicolas Nicolas NNP cord-010119-t1x9gknd 2193 5 Pineault Pineault NNP cord-010119-t1x9gknd 2194 1 2,3 2,3 LS cord-010119-t1x9gknd 2194 2 . . . cord-010119-t1x9gknd 2195 1 1 1 CD cord-010119-t1x9gknd 2195 2 Canadian Canadian NNP cord-010119-t1x9gknd 2195 3 Blood Blood NNP cord-010119-t1x9gknd 2195 4 Services Services NNPS cord-010119-t1x9gknd 2195 5 , , , cord-010119-t1x9gknd 2195 6 2 2 CD cord-010119-t1x9gknd 2195 7 University University NNP cord-010119-t1x9gknd 2195 8 Ottawa Ottawa NNP cord-010119-t1x9gknd 2195 9 , , , cord-010119-t1x9gknd 2195 10 3 3 CD cord-010119-t1x9gknd 2195 11 Canadian Canadian NNP cord-010119-t1x9gknd 2195 12 Blood Blood NNP cord-010119-t1x9gknd 2195 13 Services Services NNPS cord-010119-t1x9gknd 2195 14 , , , cord-010119-t1x9gknd 2195 15 Centre Centre NNP cord-010119-t1x9gknd 2195 16 for for IN cord-010119-t1x9gknd 2195 17 Innovation Innovation NNP cord-010119-t1x9gknd 2195 18 Background Background NNP cord-010119-t1x9gknd 2195 19 / / SYM cord-010119-t1x9gknd 2195 20 Case Case NNP cord-010119-t1x9gknd 2195 21 Studies Studies NNPS cord-010119-t1x9gknd 2195 22 : : : cord-010119-t1x9gknd 2196 1 Large large JJ cord-010119-t1x9gknd 2196 2 distances distance NNS cord-010119-t1x9gknd 2196 3 between between IN cord-010119-t1x9gknd 2196 4 collection collection NN cord-010119-t1x9gknd 2196 5 and and CC cord-010119-t1x9gknd 2196 6 processing processing NN cord-010119-t1x9gknd 2196 7 sites site NNS cord-010119-t1x9gknd 2196 8 combined combine VBN cord-010119-t1x9gknd 2196 9 with with IN cord-010119-t1x9gknd 2196 10 staff staff NN cord-010119-t1x9gknd 2196 11 availability availability NN cord-010119-t1x9gknd 2196 12 can can MD cord-010119-t1x9gknd 2196 13 result result VB cord-010119-t1x9gknd 2196 14 in in IN cord-010119-t1x9gknd 2196 15 long long JJ cord-010119-t1x9gknd 2196 16 processing processing NN cord-010119-t1x9gknd 2196 17 delays delay NNS cord-010119-t1x9gknd 2196 18 of of IN cord-010119-t1x9gknd 2196 19 umbilical umbilical JJ cord-010119-t1x9gknd 2196 20 cord cord NN cord-010119-t1x9gknd 2196 21 blood blood NN cord-010119-t1x9gknd 2196 22 ( ( -LRB- cord-010119-t1x9gknd 2196 23 UCB UCB NNP cord-010119-t1x9gknd 2196 24 ) ) -RRB- cord-010119-t1x9gknd 2196 25 unit unit NN cord-010119-t1x9gknd 2196 26 . . . cord-010119-t1x9gknd 2197 1 Current current JJ cord-010119-t1x9gknd 2197 2 NET net NN cord-010119-t1x9gknd 2197 3 - - HYPH cord-010119-t1x9gknd 2197 4 Cord cord NN cord-010119-t1x9gknd 2197 5 - - HYPH cord-010119-t1x9gknd 2197 6 FACT fact NN cord-010119-t1x9gknd 2197 7 standards standard NNS cord-010119-t1x9gknd 2197 8 specify specify VBP cord-010119-t1x9gknd 2197 9 that that IN cord-010119-t1x9gknd 2197 10 units unit NNS cord-010119-t1x9gknd 2197 11 can can MD cord-010119-t1x9gknd 2197 12 be be VB cord-010119-t1x9gknd 2197 13 stored store VBN cord-010119-t1x9gknd 2197 14 for for IN cord-010119-t1x9gknd 2197 15 almost almost RB cord-010119-t1x9gknd 2197 16 48 48 CD cord-010119-t1x9gknd 2197 17 hours hour NNS cord-010119-t1x9gknd 2197 18 at at IN cord-010119-t1x9gknd 2197 19 room room NN cord-010119-t1x9gknd 2197 20 temperature temperature NN cord-010119-t1x9gknd 2197 21 ( ( -LRB- cord-010119-t1x9gknd 2197 22 RT RT NNP cord-010119-t1x9gknd 2197 23 ) ) -RRB- cord-010119-t1x9gknd 2197 24 as as RB cord-010119-t1x9gknd 2197 25 long long RB cord-010119-t1x9gknd 2197 26 as as IN cord-010119-t1x9gknd 2197 27 units unit NNS cord-010119-t1x9gknd 2197 28 are be VBP cord-010119-t1x9gknd 2197 29 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 2197 30 by by IN cord-010119-t1x9gknd 2197 31 48-hours 48-hours CD cord-010119-t1x9gknd 2197 32 post post NN cord-010119-t1x9gknd 2197 33 - - NN cord-010119-t1x9gknd 2197 34 collection collection NN cord-010119-t1x9gknd 2197 35 . . . cord-010119-t1x9gknd 2198 1 The the DT cord-010119-t1x9gknd 2198 2 impact impact NN cord-010119-t1x9gknd 2198 3 of of IN cord-010119-t1x9gknd 2198 4 such such JJ cord-010119-t1x9gknd 2198 5 delay delay NN cord-010119-t1x9gknd 2198 6 on on IN cord-010119-t1x9gknd 2198 7 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 2198 8 stem stem NN cord-010119-t1x9gknd 2198 9 cell cell NN cord-010119-t1x9gknd 2198 10 ( ( -LRB- cord-010119-t1x9gknd 2198 11 HSC HSC NNP cord-010119-t1x9gknd 2198 12 ) ) -RRB- cord-010119-t1x9gknd 2198 13 function function NN cord-010119-t1x9gknd 2198 14 is be VBZ cord-010119-t1x9gknd 2198 15 unclear unclear JJ cord-010119-t1x9gknd 2198 16 since since IN cord-010119-t1x9gknd 2198 17 most most JJS cord-010119-t1x9gknd 2198 18 studies study NNS cord-010119-t1x9gknd 2198 19 have have VBP cord-010119-t1x9gknd 2198 20 not not RB cord-010119-t1x9gknd 2198 21 used use VBN cord-010119-t1x9gknd 2198 22 transplantation transplantation NN cord-010119-t1x9gknd 2198 23 assays assay NNS cord-010119-t1x9gknd 2198 24 that that WDT cord-010119-t1x9gknd 2198 25 measure measure VBP cord-010119-t1x9gknd 2198 26 HSC HSC NNP cord-010119-t1x9gknd 2198 27 key key JJ cord-010119-t1x9gknd 2198 28 properties property NNS cord-010119-t1x9gknd 2198 29 and and CC cord-010119-t1x9gknd 2198 30 activities activity NNS cord-010119-t1x9gknd 2198 31 . . . cord-010119-t1x9gknd 2199 1 We -PRON- PRP cord-010119-t1x9gknd 2199 2 hypothesized hypothesize VBD cord-010119-t1x9gknd 2199 3 that that IN cord-010119-t1x9gknd 2199 4 such such JJ cord-010119-t1x9gknd 2199 5 processing processing NN cord-010119-t1x9gknd 2199 6 delay delay NN cord-010119-t1x9gknd 2199 7 reduces reduce VBZ cord-010119-t1x9gknd 2199 8 the the DT cord-010119-t1x9gknd 2199 9 engraftment engraftment NN cord-010119-t1x9gknd 2199 10 activities activity NNS cord-010119-t1x9gknd 2199 11 of of IN cord-010119-t1x9gknd 2199 12 UCB UCB NNP cord-010119-t1x9gknd 2199 13 units unit NNS cord-010119-t1x9gknd 2199 14 . . . cord-010119-t1x9gknd 2200 1 We -PRON- PRP cord-010119-t1x9gknd 2200 2 set set VBD cord-010119-t1x9gknd 2200 3 out out RP cord-010119-t1x9gknd 2200 4 to to TO cord-010119-t1x9gknd 2200 5 measure measure VB cord-010119-t1x9gknd 2200 6 the the DT cord-010119-t1x9gknd 2200 7 loss loss NN cord-010119-t1x9gknd 2200 8 in in IN cord-010119-t1x9gknd 2200 9 engraftment engraftment NN cord-010119-t1x9gknd 2200 10 activities activity NNS cord-010119-t1x9gknd 2200 11 associated associate VBN cord-010119-t1x9gknd 2200 12 with with IN cord-010119-t1x9gknd 2200 13 preprocessing preprocessing NN cord-010119-t1x9gknd 2200 14 storage storage NN cord-010119-t1x9gknd 2200 15 . . . cord-010119-t1x9gknd 2201 1 Study Study NNP cord-010119-t1x9gknd 2201 2 Design Design NNP cord-010119-t1x9gknd 2201 3 / / SYM cord-010119-t1x9gknd 2201 4 Method method NN cord-010119-t1x9gknd 2201 5 : : : cord-010119-t1x9gknd 2201 6 UCB UCB NNP cord-010119-t1x9gknd 2201 7 units unit NNS cord-010119-t1x9gknd 2201 8 ( ( -LRB- cord-010119-t1x9gknd 2201 9 n53 n53 NN cord-010119-t1x9gknd 2201 10 ) ) -RRB- cord-010119-t1x9gknd 2201 11 were be VBD cord-010119-t1x9gknd 2201 12 split split VBN cord-010119-t1x9gknd 2201 13 with with IN cord-010119-t1x9gknd 2201 14 one one CD cord-010119-t1x9gknd 2201 15 half half NN cord-010119-t1x9gknd 2201 16 processed process VBN cord-010119-t1x9gknd 2201 17 immediately immediately RB cord-010119-t1x9gknd 2201 18 ( ( -LRB- cord-010119-t1x9gknd 2201 19 baseline baseline JJ cord-010119-t1x9gknd 2201 20 8 8 CD cord-010119-t1x9gknd 2201 21 - - SYM cord-010119-t1x9gknd 2201 22 12 12 CD cord-010119-t1x9gknd 2201 23 hours hour NNS cord-010119-t1x9gknd 2201 24 ) ) -RRB- cord-010119-t1x9gknd 2201 25 and and CC cord-010119-t1x9gknd 2201 26 the the DT cord-010119-t1x9gknd 2201 27 second second JJ cord-010119-t1x9gknd 2201 28 after after IN cord-010119-t1x9gknd 2201 29 43 43 CD cord-010119-t1x9gknd 2201 30 hours hour NNS cord-010119-t1x9gknd 2201 31 storage storage NN cord-010119-t1x9gknd 2201 32 at at IN cord-010119-t1x9gknd 2201 33 RT RT NNP cord-010119-t1x9gknd 2201 34 . . . cord-010119-t1x9gknd 2202 1 UCB UCB NNP cord-010119-t1x9gknd 2202 2 were be VBD cord-010119-t1x9gknd 2202 3 then then RB cord-010119-t1x9gknd 2202 4 processed process VBN cord-010119-t1x9gknd 2202 5 with with IN cord-010119-t1x9gknd 2202 6 hetastarch hetastarch NNP cord-010119-t1x9gknd 2202 7 and and CC cord-010119-t1x9gknd 2202 8 buffy buffy NNP cord-010119-t1x9gknd 2202 9 coat coat NNP cord-010119-t1x9gknd 2202 10 maintained maintain VBD cord-010119-t1x9gknd 2202 11 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 2202 12 in in IN cord-010119-t1x9gknd 2202 13 liquid liquid JJ cord-010119-t1x9gknd 2202 14 nitrogen nitrogen NN cord-010119-t1x9gknd 2202 15 until until IN cord-010119-t1x9gknd 2202 16 use use NN cord-010119-t1x9gknd 2202 17 . . . cord-010119-t1x9gknd 2203 1 Viability viability NN cord-010119-t1x9gknd 2203 2 was be VBD cord-010119-t1x9gknd 2203 3 assessed assess VBN cord-010119-t1x9gknd 2203 4 post post NN cord-010119-t1x9gknd 2203 5 - - NN cord-010119-t1x9gknd 2203 6 thaw thaw VB cord-010119-t1x9gknd 2203 7 , , , cord-010119-t1x9gknd 2203 8 and and CC cord-010119-t1x9gknd 2203 9 thawed thaw VBD cord-010119-t1x9gknd 2203 10 UCB UCB NNP cord-010119-t1x9gknd 2203 11 buffy buffy NNP cord-010119-t1x9gknd 2203 12 coat coat NN cord-010119-t1x9gknd 2203 13 cells cell NNS cord-010119-t1x9gknd 2203 14 were be VBD cord-010119-t1x9gknd 2203 15 transplanted transplant VBN cord-010119-t1x9gknd 2203 16 into into IN cord-010119-t1x9gknd 2203 17 NSG NSG NNP cord-010119-t1x9gknd 2203 18 mice mouse NNS cord-010119-t1x9gknd 2203 19 . . . cord-010119-t1x9gknd 2204 1 Serial serial JJ cord-010119-t1x9gknd 2204 2 transplantation transplantation NN cord-010119-t1x9gknd 2204 3 was be VBD cord-010119-t1x9gknd 2204 4 used use VBN cord-010119-t1x9gknd 2204 5 to to TO cord-010119-t1x9gknd 2204 6 test test VB cord-010119-t1x9gknd 2204 7 the the DT cord-010119-t1x9gknd 2204 8 self self NN cord-010119-t1x9gknd 2204 9 - - HYPH cord-010119-t1x9gknd 2204 10 renewal renewal NN cord-010119-t1x9gknd 2204 11 and and CC cord-010119-t1x9gknd 2204 12 differentiation differentiation NN cord-010119-t1x9gknd 2204 13 activities activity NNS cord-010119-t1x9gknd 2204 14 of of IN cord-010119-t1x9gknd 2204 15 HSC HSC NNP cord-010119-t1x9gknd 2204 16 , , , cord-010119-t1x9gknd 2204 17 while while IN cord-010119-t1x9gknd 2204 18 limiting limit VBG cord-010119-t1x9gknd 2204 19 dilution dilution NN cord-010119-t1x9gknd 2204 20 ( ( -LRB- cord-010119-t1x9gknd 2204 21 LD LD NNP cord-010119-t1x9gknd 2204 22 ) ) -RRB- cord-010119-t1x9gknd 2204 23 assay assay NN cord-010119-t1x9gknd 2204 24 and and CC cord-010119-t1x9gknd 2204 25 Poisson Poisson NNP cord-010119-t1x9gknd 2204 26 statistic statistic NN cord-010119-t1x9gknd 2204 27 were be VBD cord-010119-t1x9gknd 2204 28 used use VBN cord-010119-t1x9gknd 2204 29 to to TO cord-010119-t1x9gknd 2204 30 estimate estimate VB cord-010119-t1x9gknd 2204 31 the the DT cord-010119-t1x9gknd 2204 32 frequency frequency NN cord-010119-t1x9gknd 2204 33 of of IN cord-010119-t1x9gknd 2204 34 Scid scid JJ cord-010119-t1x9gknd 2204 35 repopulating repopulating NN cord-010119-t1x9gknd 2204 36 cells cell NNS cord-010119-t1x9gknd 2204 37 ( ( -LRB- cord-010119-t1x9gknd 2204 38 SRC SRC NNP cord-010119-t1x9gknd 2204 39 ) ) -RRB- cord-010119-t1x9gknd 2204 40 in in IN cord-010119-t1x9gknd 2204 41 thawed thaw VBN cord-010119-t1x9gknd 2204 42 units unit NNS cord-010119-t1x9gknd 2204 43 . . . cord-010119-t1x9gknd 2205 1 Results/ Results/ . cord-010119-t1x9gknd 2206 1 Finding finding NN cord-010119-t1x9gknd 2206 2 : : : cord-010119-t1x9gknd 2206 3 Storage storage NN cord-010119-t1x9gknd 2207 1 before before IN cord-010119-t1x9gknd 2207 2 processing processing NN cord-010119-t1x9gknd 2207 3 had have VBD cord-010119-t1x9gknd 2207 4 no no DT cord-010119-t1x9gknd 2207 5 significant significant JJ cord-010119-t1x9gknd 2207 6 impact impact NN cord-010119-t1x9gknd 2207 7 on on IN cord-010119-t1x9gknd 2207 8 the the DT cord-010119-t1x9gknd 2207 9 recovery recovery NN cord-010119-t1x9gknd 2207 10 of of IN cord-010119-t1x9gknd 2207 11 viable viable JJ cord-010119-t1x9gknd 2207 12 post post NN cord-010119-t1x9gknd 2207 13 - - JJ cord-010119-t1x9gknd 2207 14 thaw thaw JJ cord-010119-t1x9gknd 2207 15 CD451 cd451 NN cord-010119-t1x9gknd 2207 16 cells cell NNS cord-010119-t1x9gknd 2207 17 and and CC cord-010119-t1x9gknd 2207 18 CD341 cd341 NN cord-010119-t1x9gknd 2207 19 cell cell NN cord-010119-t1x9gknd 2207 20 ( ( -LRB- cord-010119-t1x9gknd 2207 21 n53 n53 NN cord-010119-t1x9gknd 2207 22 ) ) -RRB- cord-010119-t1x9gknd 2207 23 . . . cord-010119-t1x9gknd 2208 1 Primary primary JJ cord-010119-t1x9gknd 2208 2 NSG NSG NNP cord-010119-t1x9gknd 2208 3 mice mouse NNS cord-010119-t1x9gknd 2208 4 were be VBD cord-010119-t1x9gknd 2208 5 transplanted transplant VBN cord-010119-t1x9gknd 2208 6 with with IN cord-010119-t1x9gknd 2208 7 a a DT cord-010119-t1x9gknd 2208 8 UCB UCB NNP cord-010119-t1x9gknd 2208 9 cell cell NN cord-010119-t1x9gknd 2208 10 dose dose NN cord-010119-t1x9gknd 2208 11 that that WDT cord-010119-t1x9gknd 2208 12 contained contain VBD cord-010119-t1x9gknd 2208 13 a a DT cord-010119-t1x9gknd 2208 14 total total NN cord-010119-t1x9gknd 2208 15 of of IN cord-010119-t1x9gknd 2208 16 7,500 7,500 CD cord-010119-t1x9gknd 2208 17 annexinV annexinv CD cord-010119-t1x9gknd 2208 18 NEG NEG NNP cord-010119-t1x9gknd 2208 19 viable viable JJ cord-010119-t1x9gknd 2208 20 CD341 cd341 NN cord-010119-t1x9gknd 2208 21 cells cell NNS cord-010119-t1x9gknd 2208 22 . . . cord-010119-t1x9gknd 2209 1 The the DT cord-010119-t1x9gknd 2209 2 latter latter JJ cord-010119-t1x9gknd 2209 3 was be VBD cord-010119-t1x9gknd 2209 4 done do VBN cord-010119-t1x9gknd 2209 5 to to TO cord-010119-t1x9gknd 2209 6 avoid avoid VB cord-010119-t1x9gknd 2209 7 any any DT cord-010119-t1x9gknd 2209 8 bias bias NN cord-010119-t1x9gknd 2209 9 towards towards IN cord-010119-t1x9gknd 2209 10 one one CD cord-010119-t1x9gknd 2209 11 group group NN cord-010119-t1x9gknd 2209 12 or or CC cord-010119-t1x9gknd 2209 13 another another DT cord-010119-t1x9gknd 2209 14 . . . cord-010119-t1x9gknd 2210 1 Short short JJ cord-010119-t1x9gknd 2210 2 term term NN cord-010119-t1x9gknd 2210 3 platelets platelet NNS cord-010119-t1x9gknd 2210 4 ( ( -LRB- cord-010119-t1x9gknd 2210 5 190 190 CD cord-010119-t1x9gknd 2210 6 vs. vs. IN cord-010119-t1x9gknd 2210 7 140 140 CD cord-010119-t1x9gknd 2210 8 hPlt hPlt NNP cord-010119-t1x9gknd 2210 9 / / SYM cord-010119-t1x9gknd 2210 10 mL ml NN cord-010119-t1x9gknd 2210 11 , , , cord-010119-t1x9gknd 2210 12 p50.06 p50.06 NNP cord-010119-t1x9gknd 2210 13 ) ) -RRB- cord-010119-t1x9gknd 2210 14 and and CC cord-010119-t1x9gknd 2210 15 leucocytes leucocyte NNS cord-010119-t1x9gknd 2210 16 ( ( -LRB- cord-010119-t1x9gknd 2210 17 1.2 1.2 CD cord-010119-t1x9gknd 2210 18 % % NN cord-010119-t1x9gknd 2210 19 vs. vs. CC cord-010119-t1x9gknd 2210 20 0.2 0.2 CD cord-010119-t1x9gknd 2210 21 % % NN cord-010119-t1x9gknd 2210 22 hCD451 hcd451 NN cord-010119-t1x9gknd 2210 23 , , , cord-010119-t1x9gknd 2210 24 p<0.02 p<0.02 XX cord-010119-t1x9gknd 2210 25 ) ) -RRB- cord-010119-t1x9gknd 2211 1 engraftment engraftment NNP cord-010119-t1x9gknd 2211 2 at at IN cord-010119-t1x9gknd 2211 3 4-weeks 4-weeks CD cord-010119-t1x9gknd 2211 4 were be VBD cord-010119-t1x9gknd 2211 5 significantly significantly RB cord-010119-t1x9gknd 2211 6 reduced reduce VBN cord-010119-t1x9gknd 2211 7 in in IN cord-010119-t1x9gknd 2211 8 stored store VBN cord-010119-t1x9gknd 2211 9 mice mouse NNS cord-010119-t1x9gknd 2211 10 vs. vs. IN cord-010119-t1x9gknd 2211 11 baseline baseline JJ cord-010119-t1x9gknd 2211 12 ( ( -LRB- cord-010119-t1x9gknd 2211 13 n53 n53 NN cord-010119-t1x9gknd 2211 14 ) ) -RRB- cord-010119-t1x9gknd 2211 15 , , , cord-010119-t1x9gknd 2211 16 and and CC cord-010119-t1x9gknd 2211 17 similar similar JJ cord-010119-t1x9gknd 2211 18 results result NNS cord-010119-t1x9gknd 2211 19 were be VBD cord-010119-t1x9gknd 2211 20 observed observe VBN cord-010119-t1x9gknd 2211 21 long long JJ cord-010119-t1x9gknd 2211 22 - - HYPH cord-010119-t1x9gknd 2211 23 term term NN cord-010119-t1x9gknd 2211 24 at at IN cord-010119-t1x9gknd 2211 25 16-weeks 16-weeks CD cord-010119-t1x9gknd 2211 26 . . . cord-010119-t1x9gknd 2212 1 Long long JJ cord-010119-t1x9gknd 2212 2 - - HYPH cord-010119-t1x9gknd 2212 3 term term NN cord-010119-t1x9gknd 2212 4 human human JJ cord-010119-t1x9gknd 2212 5 bone bone NN cord-010119-t1x9gknd 2212 6 marrow marrow NN cord-010119-t1x9gknd 2212 7 ( ( -LRB- cord-010119-t1x9gknd 2212 8 BM BM NNP cord-010119-t1x9gknd 2212 9 ) ) -RRB- cord-010119-t1x9gknd 2212 10 engraftment engraftment NN cord-010119-t1x9gknd 2212 11 was be VBD cord-010119-t1x9gknd 2212 12 also also RB cord-010119-t1x9gknd 2212 13 reduced reduce VBN cord-010119-t1x9gknd 2212 14 in in IN cord-010119-t1x9gknd 2212 15 primary primary JJ cord-010119-t1x9gknd 2212 16 transplants transplant NNS cord-010119-t1x9gknd 2212 17 from from IN cord-010119-t1x9gknd 2212 18 stored store VBN cord-010119-t1x9gknd 2212 19 samples sample NNS cord-010119-t1x9gknd 2212 20 ( ( -LRB- cord-010119-t1x9gknd 2212 21 myeloid myeloid NNP cord-010119-t1x9gknd 2212 22 engraftment engraftment NN cord-010119-t1x9gknd 2212 23 was be VBD cord-010119-t1x9gknd 2212 24 however however RB cord-010119-t1x9gknd 2212 25 confirmed confirm VBN cord-010119-t1x9gknd 2212 26 in in IN cord-010119-t1x9gknd 2212 27 both both DT cord-010119-t1x9gknd 2212 28 groups group NNS cord-010119-t1x9gknd 2212 29 . . . cord-010119-t1x9gknd 2213 1 BM BM NNP cord-010119-t1x9gknd 2213 2 cells cell NNS cord-010119-t1x9gknd 2213 3 from from IN cord-010119-t1x9gknd 2213 4 primary primary JJ cord-010119-t1x9gknd 2213 5 mice mouse NNS cord-010119-t1x9gknd 2213 6 were be VBD cord-010119-t1x9gknd 2213 7 transplanted transplant VBN cord-010119-t1x9gknd 2213 8 into into IN cord-010119-t1x9gknd 2213 9 secondary secondary JJ cord-010119-t1x9gknd 2213 10 recipients recipient NNS cord-010119-t1x9gknd 2213 11 and and CC cord-010119-t1x9gknd 2213 12 human human JJ cord-010119-t1x9gknd 2213 13 engraftment engraftment NN cord-010119-t1x9gknd 2213 14 investigated investigate VBD cord-010119-t1x9gknd 2213 15 3 3 CD cord-010119-t1x9gknd 2213 16 months month NNS cord-010119-t1x9gknd 2213 17 post post JJ cord-010119-t1x9gknd 2213 18 - - NN cord-010119-t1x9gknd 2213 19 transplant transplant NN cord-010119-t1x9gknd 2213 20 . . . cord-010119-t1x9gknd 2214 1 Strikingly strikingly RB cord-010119-t1x9gknd 2214 2 , , , cord-010119-t1x9gknd 2214 3 the the DT cord-010119-t1x9gknd 2214 4 frequency frequency NN cord-010119-t1x9gknd 2214 5 of of IN cord-010119-t1x9gknd 2214 6 human human JJ cord-010119-t1x9gknd 2214 7 CD451 cd451 NN cord-010119-t1x9gknd 2214 8 BM BM NNP cord-010119-t1x9gknd 2214 9 cells cell NNS cord-010119-t1x9gknd 2214 10 was be VBD cord-010119-t1x9gknd 2214 11 10-fold 10-fold RB cord-010119-t1x9gknd 2214 12 greater great JJR cord-010119-t1x9gknd 2214 13 in in IN cord-010119-t1x9gknd 2214 14 baseline baseline NN cord-010119-t1x9gknd 2214 15 vs. vs. FW cord-010119-t1x9gknd 2214 16 stored store VBN cord-010119-t1x9gknd 2214 17 mice mouse NNS cord-010119-t1x9gknd 2214 18 ( ( -LRB- cord-010119-t1x9gknd 2214 19 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 2214 20 , , , cord-010119-t1x9gknd 2214 21 n52 n52 NNP cord-010119-t1x9gknd 2214 22 ) ) -RRB- cord-010119-t1x9gknd 2214 23 . . . cord-010119-t1x9gknd 2215 1 Hence hence RB cord-010119-t1x9gknd 2215 2 , , , cord-010119-t1x9gknd 2215 3 storage storage NN cord-010119-t1x9gknd 2215 4 at at IN cord-010119-t1x9gknd 2215 5 RT RT NNP cord-010119-t1x9gknd 2215 6 of of IN cord-010119-t1x9gknd 2215 7 UCB UCB NNP cord-010119-t1x9gknd 2215 8 units unit NNS cord-010119-t1x9gknd 2215 9 is be VBZ cord-010119-t1x9gknd 2215 10 associated associate VBN cord-010119-t1x9gknd 2215 11 with with IN cord-010119-t1x9gknd 2215 12 a a DT cord-010119-t1x9gknd 2215 13 deficit deficit NN cord-010119-t1x9gknd 2215 14 in in IN cord-010119-t1x9gknd 2215 15 engraftment engraftment NN cord-010119-t1x9gknd 2215 16 activity activity NN cord-010119-t1x9gknd 2215 17 likely likely RB cord-010119-t1x9gknd 2215 18 due due IN cord-010119-t1x9gknd 2215 19 to to IN cord-010119-t1x9gknd 2215 20 a a DT cord-010119-t1x9gknd 2215 21 loss loss NN cord-010119-t1x9gknd 2215 22 in in IN cord-010119-t1x9gknd 2215 23 HSC HSC NNP cord-010119-t1x9gknd 2215 24 activity activity NN cord-010119-t1x9gknd 2215 25 and/or and/or CC cord-010119-t1x9gknd 2215 26 numbers number NNS cord-010119-t1x9gknd 2215 27 . . . cord-010119-t1x9gknd 2216 1 To to IN cord-010119-t1x9gknd 2216 2 distinct distinct JJ cord-010119-t1x9gknd 2216 3 between between IN cord-010119-t1x9gknd 2216 4 both both DT cord-010119-t1x9gknd 2216 5 possibilities possibility NNS cord-010119-t1x9gknd 2216 6 , , , cord-010119-t1x9gknd 2216 7 the the DT cord-010119-t1x9gknd 2216 8 net net JJ cord-010119-t1x9gknd 2216 9 number number NN cord-010119-t1x9gknd 2216 10 of of IN cord-010119-t1x9gknd 2216 11 SRC SRC NNP cord-010119-t1x9gknd 2216 12 in in IN cord-010119-t1x9gknd 2216 13 baseline baseline NN cord-010119-t1x9gknd 2216 14 and and CC cord-010119-t1x9gknd 2216 15 stored store VBN cord-010119-t1x9gknd 2216 16 samples sample NNS cord-010119-t1x9gknd 2216 17 for for IN cord-010119-t1x9gknd 2216 18 two two CD cord-010119-t1x9gknd 2216 19 units unit NNS cord-010119-t1x9gknd 2216 20 were be VBD cord-010119-t1x9gknd 2216 21 calculated calculate VBN cord-010119-t1x9gknd 2216 22 by by IN cord-010119-t1x9gknd 2216 23 LD LD NNP cord-010119-t1x9gknd 2216 24 transplantation transplantation NN cord-010119-t1x9gknd 2216 25 assay assay NN cord-010119-t1x9gknd 2216 26 . . . cord-010119-t1x9gknd 2217 1 The the DT cord-010119-t1x9gknd 2217 2 net net JJ cord-010119-t1x9gknd 2217 3 number number NN cord-010119-t1x9gknd 2217 4 of of IN cord-010119-t1x9gknd 2217 5 SRC SRC NNP cord-010119-t1x9gknd 2217 6 measured measure VBD cord-010119-t1x9gknd 2217 7 22-weeks 22-weeks CD cord-010119-t1x9gknd 2217 8 post post NN cord-010119-t1x9gknd 2217 9 - - NNS cord-010119-t1x9gknd 2217 10 transplants transplant NNS cord-010119-t1x9gknd 2217 11 were be VBD cord-010119-t1x9gknd 2217 12 reduced reduce VBN cord-010119-t1x9gknd 2217 13 by by IN cord-010119-t1x9gknd 2217 14 30 30 CD cord-010119-t1x9gknd 2217 15 % % NN cord-010119-t1x9gknd 2217 16 in in IN cord-010119-t1x9gknd 2217 17 unit unit NN cord-010119-t1x9gknd 2217 18 1 1 CD cord-010119-t1x9gknd 2217 19 , , , cord-010119-t1x9gknd 2217 20 and and CC cord-010119-t1x9gknd 2217 21 by by IN cord-010119-t1x9gknd 2217 22 80 80 CD cord-010119-t1x9gknd 2217 23 % % NN cord-010119-t1x9gknd 2217 24 in in IN cord-010119-t1x9gknd 2217 25 unit unit NN cord-010119-t1x9gknd 2217 26 2 2 CD cord-010119-t1x9gknd 2217 27 . . . cord-010119-t1x9gknd 2218 1 Conclusion conclusion NN cord-010119-t1x9gknd 2218 2 : : : cord-010119-t1x9gknd 2218 3 Prolonged prolonged JJ cord-010119-t1x9gknd 2218 4 preprocessing preprocessing NN cord-010119-t1x9gknd 2218 5 RT rt NN cord-010119-t1x9gknd 2218 6 storage storage NN cord-010119-t1x9gknd 2218 7 significantly significantly RB cord-010119-t1x9gknd 2218 8 impairs impair VBZ cord-010119-t1x9gknd 2218 9 the the DT cord-010119-t1x9gknd 2218 10 engraftment engraftment NN cord-010119-t1x9gknd 2218 11 activities activity NNS cord-010119-t1x9gknd 2218 12 of of IN cord-010119-t1x9gknd 2218 13 UCB UCB NNP cord-010119-t1x9gknd 2218 14 units unit NNS cord-010119-t1x9gknd 2218 15 . . . cord-010119-t1x9gknd 2219 1 The the DT cord-010119-t1x9gknd 2219 2 reduced reduce VBN cord-010119-t1x9gknd 2219 3 engraftment engraftment NN cord-010119-t1x9gknd 2219 4 in in IN cord-010119-t1x9gknd 2219 5 secondary secondary JJ cord-010119-t1x9gknd 2219 6 transplants transplant NNS cord-010119-t1x9gknd 2219 7 coupled couple VBN cord-010119-t1x9gknd 2219 8 with with IN cord-010119-t1x9gknd 2219 9 the the DT cord-010119-t1x9gknd 2219 10 results result NNS cord-010119-t1x9gknd 2219 11 from from IN cord-010119-t1x9gknd 2219 12 the the DT cord-010119-t1x9gknd 2219 13 LD LD NNP cord-010119-t1x9gknd 2219 14 assays assay NNS cord-010119-t1x9gknd 2219 15 suggest suggest VBP cord-010119-t1x9gknd 2219 16 that that IN cord-010119-t1x9gknd 2219 17 this this DT cord-010119-t1x9gknd 2219 18 engraftment engraftment NN cord-010119-t1x9gknd 2219 19 deficit deficit NN cord-010119-t1x9gknd 2219 20 origins origin NNS cord-010119-t1x9gknd 2219 21 from from IN cord-010119-t1x9gknd 2219 22 loss loss NN cord-010119-t1x9gknd 2219 23 of of IN cord-010119-t1x9gknd 2219 24 HSC HSC NNP cord-010119-t1x9gknd 2219 25 numbers number NNS cord-010119-t1x9gknd 2219 26 . . . cord-010119-t1x9gknd 2220 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2220 2 results result NNS cord-010119-t1x9gknd 2220 3 stress stress VBP cord-010119-t1x9gknd 2220 4 the the DT cord-010119-t1x9gknd 2220 5 importance importance NN cord-010119-t1x9gknd 2220 6 of of IN cord-010119-t1x9gknd 2220 7 rapid rapid JJ cord-010119-t1x9gknd 2220 8 UCB UCB NNP cord-010119-t1x9gknd 2220 9 processing processing NN cord-010119-t1x9gknd 2220 10 to to TO cord-010119-t1x9gknd 2220 11 avoid avoid VB cord-010119-t1x9gknd 2220 12 loss loss NN cord-010119-t1x9gknd 2220 13 of of IN cord-010119-t1x9gknd 2220 14 engraftment engraftment NN cord-010119-t1x9gknd 2220 15 activity activity NN cord-010119-t1x9gknd 2220 16 . . . cord-010119-t1x9gknd 2221 1 Acoustic acoustic JJ cord-010119-t1x9gknd 2221 2 Microfluidic Microfluidic NNP cord-010119-t1x9gknd 2221 3 Separation Separation NNP cord-010119-t1x9gknd 2221 4 of of IN cord-010119-t1x9gknd 2221 5 Blood Blood NNP cord-010119-t1x9gknd 2221 6 Components Components NNP cord-010119-t1x9gknd 2221 7 Charles Charles NNP cord-010119-t1x9gknd 2221 8 Lissandrello Lissandrello NNP cord-010119-t1x9gknd 2221 9 , , , cord-010119-t1x9gknd 2221 10 Ryan Ryan NNP cord-010119-t1x9gknd 2221 11 Dubay Dubay NNP cord-010119-t1x9gknd 2221 12 , , , cord-010119-t1x9gknd 2221 13 Kenneth Kenneth NNP cord-010119-t1x9gknd 2221 14 Kotz Kotz NNP cord-010119-t1x9gknd 2221 15 and and CC cord-010119-t1x9gknd 2221 16 Jason Jason NNP cord-010119-t1x9gknd 2221 17 Fiering Fiering NNP cord-010119-t1x9gknd 2222 1 * * NFP cord-010119-t1x9gknd 2222 2 . . . cord-010119-t1x9gknd 2223 1 Draper Draper NNP cord-010119-t1x9gknd 2223 2 Background Background NNP cord-010119-t1x9gknd 2223 3 / / SYM cord-010119-t1x9gknd 2223 4 Case Case NNP cord-010119-t1x9gknd 2223 5 Studies Studies NNPS cord-010119-t1x9gknd 2223 6 : : : cord-010119-t1x9gknd 2224 1 New new JJ cord-010119-t1x9gknd 2224 2 cell cell NN cord-010119-t1x9gknd 2224 3 therapies therapy NNS cord-010119-t1x9gknd 2224 4 require require VBP cord-010119-t1x9gknd 2224 5 efficient efficient JJ cord-010119-t1x9gknd 2224 6 and and CC cord-010119-t1x9gknd 2224 7 automated automate VBN cord-010119-t1x9gknd 2224 8 methods method NNS cord-010119-t1x9gknd 2224 9 for for IN cord-010119-t1x9gknd 2224 10 purification purification NN cord-010119-t1x9gknd 2224 11 of of IN cord-010119-t1x9gknd 2224 12 target target NN cord-010119-t1x9gknd 2224 13 cells cell NNS cord-010119-t1x9gknd 2224 14 prior prior RB cord-010119-t1x9gknd 2224 15 to to IN cord-010119-t1x9gknd 2224 16 subsequent subsequent JJ cord-010119-t1x9gknd 2224 17 processing processing NN cord-010119-t1x9gknd 2224 18 . . . cord-010119-t1x9gknd 2225 1 While while IN cord-010119-t1x9gknd 2225 2 apheresis apheresis NN cord-010119-t1x9gknd 2225 3 , , , cord-010119-t1x9gknd 2225 4 density density NN cord-010119-t1x9gknd 2225 5 gradient gradient NN cord-010119-t1x9gknd 2225 6 centrifugation centrifugation NN cord-010119-t1x9gknd 2225 7 , , , cord-010119-t1x9gknd 2225 8 and and CC cord-010119-t1x9gknd 2225 9 magnetic magnetic JJ cord-010119-t1x9gknd 2225 10 separation separation NN cord-010119-t1x9gknd 2225 11 achieve achieve VBP cord-010119-t1x9gknd 2225 12 some some DT cord-010119-t1x9gknd 2225 13 of of IN cord-010119-t1x9gknd 2225 14 the the DT cord-010119-t1x9gknd 2225 15 requirements requirement NNS cord-010119-t1x9gknd 2225 16 , , , cord-010119-t1x9gknd 2225 17 no no DT cord-010119-t1x9gknd 2225 18 method method NN cord-010119-t1x9gknd 2225 19 is be VBZ cord-010119-t1x9gknd 2225 20 currently currently RB cord-010119-t1x9gknd 2225 21 available available JJ cord-010119-t1x9gknd 2225 22 that that IN cord-010119-t1x9gknd 2225 23 fully fully RB cord-010119-t1x9gknd 2225 24 meets meet VBZ cord-010119-t1x9gknd 2225 25 clinical clinical JJ cord-010119-t1x9gknd 2225 26 needs need NNS cord-010119-t1x9gknd 2225 27 for for IN cord-010119-t1x9gknd 2225 28 a a DT cord-010119-t1x9gknd 2225 29 closed closed JJ cord-010119-t1x9gknd 2225 30 , , , cord-010119-t1x9gknd 2225 31 automated automate VBN cord-010119-t1x9gknd 2225 32 , , , cord-010119-t1x9gknd 2225 33 and and CC cord-010119-t1x9gknd 2225 34 scalable scalable JJ cord-010119-t1x9gknd 2225 35 process process NN cord-010119-t1x9gknd 2225 36 . . . cord-010119-t1x9gknd 2226 1 Continuous continuous JJ cord-010119-t1x9gknd 2226 2 acoustic acoustic JJ cord-010119-t1x9gknd 2226 3 separation separation NN cord-010119-t1x9gknd 2226 4 in in IN cord-010119-t1x9gknd 2226 5 microchannels microchannel NNS cord-010119-t1x9gknd 2226 6 is be VBZ cord-010119-t1x9gknd 2226 7 emerging emerge VBG cord-010119-t1x9gknd 2226 8 as as IN cord-010119-t1x9gknd 2226 9 a a DT cord-010119-t1x9gknd 2226 10 versatile versatile JJ cord-010119-t1x9gknd 2226 11 method method NN cord-010119-t1x9gknd 2226 12 for for IN cord-010119-t1x9gknd 2226 13 sorting sort VBG cord-010119-t1x9gknd 2226 14 , , , cord-010119-t1x9gknd 2226 15 separating separate VBG cord-010119-t1x9gknd 2226 16 , , , cord-010119-t1x9gknd 2226 17 and and CC cord-010119-t1x9gknd 2226 18 concentrating concentrate VBG cord-010119-t1x9gknd 2226 19 cells cell NNS cord-010119-t1x9gknd 2226 20 from from IN cord-010119-t1x9gknd 2226 21 blood blood NN cord-010119-t1x9gknd 2226 22 . . . cord-010119-t1x9gknd 2227 1 It -PRON- PRP cord-010119-t1x9gknd 2227 2 has have VBZ cord-010119-t1x9gknd 2227 3 advantages advantage NNS cord-010119-t1x9gknd 2227 4 over over IN cord-010119-t1x9gknd 2227 5 centrifugation centrifugation NN cord-010119-t1x9gknd 2227 6 because because IN cord-010119-t1x9gknd 2227 7 it -PRON- PRP cord-010119-t1x9gknd 2227 8 is be VBZ cord-010119-t1x9gknd 2227 9 scalable scalable JJ cord-010119-t1x9gknd 2227 10 to to IN cord-010119-t1x9gknd 2227 11 small small JJ cord-010119-t1x9gknd 2227 12 or or CC cord-010119-t1x9gknd 2227 13 large large JJ cord-010119-t1x9gknd 2227 14 quantities quantity NNS cord-010119-t1x9gknd 2227 15 and and CC cord-010119-t1x9gknd 2227 16 can can MD cord-010119-t1x9gknd 2227 17 discriminate discriminate VB cord-010119-t1x9gknd 2227 18 cells cell NNS cord-010119-t1x9gknd 2227 19 by by IN cord-010119-t1x9gknd 2227 20 size size NN cord-010119-t1x9gknd 2227 21 as as RB cord-010119-t1x9gknd 2227 22 well well RB cord-010119-t1x9gknd 2227 23 as as IN cord-010119-t1x9gknd 2227 24 density density NN cord-010119-t1x9gknd 2227 25 . . . cord-010119-t1x9gknd 2228 1 Meanwhile meanwhile RB cord-010119-t1x9gknd 2228 2 , , , cord-010119-t1x9gknd 2228 3 unlike unlike IN cord-010119-t1x9gknd 2228 4 magnetic magnetic JJ cord-010119-t1x9gknd 2228 5 methods method NNS cord-010119-t1x9gknd 2228 6 , , , cord-010119-t1x9gknd 2228 7 acoustophoresis acoustophoresis NNP cord-010119-t1x9gknd 2228 8 is be VBZ cord-010119-t1x9gknd 2228 9 " " `` cord-010119-t1x9gknd 2228 10 label label NN cord-010119-t1x9gknd 2228 11 free free JJ cord-010119-t1x9gknd 2228 12 " " '' cord-010119-t1x9gknd 2228 13 and and CC cord-010119-t1x9gknd 2228 14 adds add VBZ cord-010119-t1x9gknd 2228 15 no no DT cord-010119-t1x9gknd 2228 16 reagents reagent NNS cord-010119-t1x9gknd 2228 17 to to IN cord-010119-t1x9gknd 2228 18 the the DT cord-010119-t1x9gknd 2228 19 therapeutic therapeutic JJ cord-010119-t1x9gknd 2228 20 cells cell NNS cord-010119-t1x9gknd 2228 21 . . . cord-010119-t1x9gknd 2229 1 It -PRON- PRP cord-010119-t1x9gknd 2229 2 has have VBZ cord-010119-t1x9gknd 2229 3 been be VBN cord-010119-t1x9gknd 2229 4 shown show VBN cord-010119-t1x9gknd 2229 5 previously previously RB cord-010119-t1x9gknd 2229 6 that that IN cord-010119-t1x9gknd 2229 7 acoustic acoustic JJ cord-010119-t1x9gknd 2229 8 separation separation NN cord-010119-t1x9gknd 2229 9 can can MD cord-010119-t1x9gknd 2229 10 separate separate VB cord-010119-t1x9gknd 2229 11 blood blood NN cord-010119-t1x9gknd 2229 12 components component NNS cord-010119-t1x9gknd 2229 13 including include VBG cord-010119-t1x9gknd 2229 14 purification purification NN cord-010119-t1x9gknd 2229 15 of of IN cord-010119-t1x9gknd 2229 16 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 2229 17 . . . cord-010119-t1x9gknd 2230 1 However however RB cord-010119-t1x9gknd 2230 2 , , , cord-010119-t1x9gknd 2230 3 these these DT cord-010119-t1x9gknd 2230 4 studies study NNS cord-010119-t1x9gknd 2230 5 used use VBD cord-010119-t1x9gknd 2230 6 devices device NNS cord-010119-t1x9gknd 2230 7 that that WDT cord-010119-t1x9gknd 2230 8 were be VBD cord-010119-t1x9gknd 2230 9 constructed construct VBN cord-010119-t1x9gknd 2230 10 from from IN cord-010119-t1x9gknd 2230 11 silicon silicon NN cord-010119-t1x9gknd 2230 12 or or CC cord-010119-t1x9gknd 2230 13 glass glass NN cord-010119-t1x9gknd 2230 14 and and CC cord-010119-t1x9gknd 2230 15 have have VBP cord-010119-t1x9gknd 2230 16 limited limit VBN cord-010119-t1x9gknd 2230 17 potential potential NN cord-010119-t1x9gknd 2230 18 for for IN cord-010119-t1x9gknd 2230 19 scale scale NN cord-010119-t1x9gknd 2230 20 - - HYPH cord-010119-t1x9gknd 2230 21 up up NN cord-010119-t1x9gknd 2230 22 or or CC cord-010119-t1x9gknd 2230 23 production production NN cord-010119-t1x9gknd 2230 24 as as IN cord-010119-t1x9gknd 2230 25 disposable disposable JJ cord-010119-t1x9gknd 2230 26 cartridges cartridge NNS cord-010119-t1x9gknd 2230 27 . . . cord-010119-t1x9gknd 2231 1 In in IN cord-010119-t1x9gknd 2231 2 contrast contrast NN cord-010119-t1x9gknd 2231 3 , , , cord-010119-t1x9gknd 2231 4 we -PRON- PRP cord-010119-t1x9gknd 2231 5 report report VBP cord-010119-t1x9gknd 2231 6 the the DT cord-010119-t1x9gknd 2231 7 first first JJ cord-010119-t1x9gknd 2231 8 ever ever RB cord-010119-t1x9gknd 2231 9 demonstration demonstration NN cord-010119-t1x9gknd 2231 10 of of IN cord-010119-t1x9gknd 2231 11 acoustic acoustic JJ cord-010119-t1x9gknd 2231 12 lymphocyte lymphocyte NN cord-010119-t1x9gknd 2231 13 enrichment enrichment NN cord-010119-t1x9gknd 2231 14 along along IN cord-010119-t1x9gknd 2231 15 with with IN cord-010119-t1x9gknd 2231 16 RBC RBC NNP cord-010119-t1x9gknd 2231 17 and and CC cord-010119-t1x9gknd 2231 18 platelet platelet NN cord-010119-t1x9gknd 2231 19 depletion depletion NN cord-010119-t1x9gknd 2231 20 in in IN cord-010119-t1x9gknd 2231 21 a a DT cord-010119-t1x9gknd 2231 22 disposable disposable JJ cord-010119-t1x9gknd 2231 23 plastic plastic NN cord-010119-t1x9gknd 2231 24 chip chip NN cord-010119-t1x9gknd 2231 25 , , , cord-010119-t1x9gknd 2231 26 and and CC cord-010119-t1x9gknd 2231 27 we -PRON- PRP cord-010119-t1x9gknd 2231 28 present present VBP cord-010119-t1x9gknd 2231 29 a a DT cord-010119-t1x9gknd 2231 30 cartridge cartridge NN cord-010119-t1x9gknd 2231 31 concept concept NN cord-010119-t1x9gknd 2231 32 that that WDT cord-010119-t1x9gknd 2231 33 enables enable VBZ cord-010119-t1x9gknd 2231 34 clinical clinical JJ cord-010119-t1x9gknd 2231 35 scale scale NN cord-010119-t1x9gknd 2231 36 throughput throughput NN cord-010119-t1x9gknd 2231 37 by by IN cord-010119-t1x9gknd 2231 38 linking link VBG cord-010119-t1x9gknd 2231 39 microchannels microchannel NNS cord-010119-t1x9gknd 2231 40 in in IN cord-010119-t1x9gknd 2231 41 parallel parallel NN cord-010119-t1x9gknd 2231 42 . . . cord-010119-t1x9gknd 2232 1 Study Study NNP cord-010119-t1x9gknd 2232 2 Design Design NNP cord-010119-t1x9gknd 2232 3 / / SYM cord-010119-t1x9gknd 2232 4 Method method NN cord-010119-t1x9gknd 2232 5 : : : cord-010119-t1x9gknd 2232 6 Acoustophoresis Acoustophoresis NNP cord-010119-t1x9gknd 2232 7 uses use VBZ cord-010119-t1x9gknd 2232 8 ultrasonic ultrasonic JJ cord-010119-t1x9gknd 2232 9 waves wave NNS cord-010119-t1x9gknd 2232 10 to to TO cord-010119-t1x9gknd 2232 11 oscillate oscillate VB cord-010119-t1x9gknd 2232 12 a a DT cord-010119-t1x9gknd 2232 13 rectangular rectangular JJ cord-010119-t1x9gknd 2232 14 microchannel microchannel NN cord-010119-t1x9gknd 2232 15 having have VBG cord-010119-t1x9gknd 2232 16 a a DT cord-010119-t1x9gknd 2232 17 cross cross NN cord-010119-t1x9gknd 2232 18 section section NN cord-010119-t1x9gknd 2232 19 on on IN cord-010119-t1x9gknd 2232 20 the the DT cord-010119-t1x9gknd 2232 21 scale scale NN cord-010119-t1x9gknd 2232 22 of of IN cord-010119-t1x9gknd 2232 23 the the DT cord-010119-t1x9gknd 2232 24 ultrasonic ultrasonic JJ cord-010119-t1x9gknd 2232 25 wavelength wavelength NN cord-010119-t1x9gknd 2232 26 ( ( -LRB- cord-010119-t1x9gknd 2232 27 $ $ $ cord-010119-t1x9gknd 2232 28 1 1 CD cord-010119-t1x9gknd 2232 29 mm mm CD cord-010119-t1x9gknd 2232 30 ) ) -RRB- cord-010119-t1x9gknd 2232 31 . . . cord-010119-t1x9gknd 2233 1 This this DT cord-010119-t1x9gknd 2233 2 results result VBZ cord-010119-t1x9gknd 2233 3 in in IN cord-010119-t1x9gknd 2233 4 an an DT cord-010119-t1x9gknd 2233 5 acoustic acoustic JJ cord-010119-t1x9gknd 2233 6 force force NN cord-010119-t1x9gknd 2233 7 across across IN cord-010119-t1x9gknd 2233 8 the the DT cord-010119-t1x9gknd 2233 9 channel channel NN cord-010119-t1x9gknd 2233 10 that that WDT cord-010119-t1x9gknd 2233 11 drives drive VBZ cord-010119-t1x9gknd 2233 12 cells cell NNS cord-010119-t1x9gknd 2233 13 toward toward IN cord-010119-t1x9gknd 2233 14 the the DT cord-010119-t1x9gknd 2233 15 axial axial JJ cord-010119-t1x9gknd 2233 16 center center NN cord-010119-t1x9gknd 2233 17 stream stream NN cord-010119-t1x9gknd 2233 18 . . . cord-010119-t1x9gknd 2234 1 Because because IN cord-010119-t1x9gknd 2234 2 the the DT cord-010119-t1x9gknd 2234 3 force force NN cord-010119-t1x9gknd 2234 4 increases increase VBZ cord-010119-t1x9gknd 2234 5 with with IN cord-010119-t1x9gknd 2234 6 a a DT cord-010119-t1x9gknd 2234 7 cell cell NN cord-010119-t1x9gknd 2234 8 's 's POS cord-010119-t1x9gknd 2234 9 size size NN cord-010119-t1x9gknd 2234 10 and and CC cord-010119-t1x9gknd 2234 11 density density NN cord-010119-t1x9gknd 2234 12 , , , cord-010119-t1x9gknd 2234 13 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 2234 14 experience experience VBP cord-010119-t1x9gknd 2234 15 a a DT cord-010119-t1x9gknd 2234 16 weaker weak JJR cord-010119-t1x9gknd 2234 17 force force NN cord-010119-t1x9gknd 2234 18 than than IN cord-010119-t1x9gknd 2234 19 RBCs rbc NNS cord-010119-t1x9gknd 2234 20 and and CC cord-010119-t1x9gknd 2234 21 other other JJ cord-010119-t1x9gknd 2234 22 classes class NNS cord-010119-t1x9gknd 2234 23 of of IN cord-010119-t1x9gknd 2234 24 WBCs wbc NNS cord-010119-t1x9gknd 2234 25 . . . cord-010119-t1x9gknd 2235 1 Thus thus RB cord-010119-t1x9gknd 2235 2 , , , cord-010119-t1x9gknd 2235 3 as as IN cord-010119-t1x9gknd 2235 4 blood blood NN cord-010119-t1x9gknd 2235 5 product product NN cord-010119-t1x9gknd 2235 6 flows flow VBZ cord-010119-t1x9gknd 2235 7 through through IN cord-010119-t1x9gknd 2235 8 the the DT cord-010119-t1x9gknd 2235 9 device device NN cord-010119-t1x9gknd 2235 10 , , , cord-010119-t1x9gknd 2235 11 the the DT cord-010119-t1x9gknd 2235 12 lymphocyte lymphocyte NN cord-010119-t1x9gknd 2235 13 population population NN cord-010119-t1x9gknd 2235 14 is be VBZ cord-010119-t1x9gknd 2235 15 enriched enrich VBN cord-010119-t1x9gknd 2235 16 at at IN cord-010119-t1x9gknd 2235 17 the the DT cord-010119-t1x9gknd 2235 18 sides side NNS cord-010119-t1x9gknd 2235 19 of of IN cord-010119-t1x9gknd 2235 20 the the DT cord-010119-t1x9gknd 2235 21 channel channel NN cord-010119-t1x9gknd 2235 22 and and CC cord-010119-t1x9gknd 2235 23 can can MD cord-010119-t1x9gknd 2235 24 be be VB cord-010119-t1x9gknd 2235 25 captured capture VBN cord-010119-t1x9gknd 2235 26 in in IN cord-010119-t1x9gknd 2235 27 a a DT cord-010119-t1x9gknd 2235 28 branching branch VBG cord-010119-t1x9gknd 2235 29 outlet outlet NN cord-010119-t1x9gknd 2235 30 . . . cord-010119-t1x9gknd 2236 1 Likewise likewise RB cord-010119-t1x9gknd 2236 2 , , , cord-010119-t1x9gknd 2236 3 platelets platelet NNS cord-010119-t1x9gknd 2236 4 can can MD cord-010119-t1x9gknd 2236 5 by by IN cord-010119-t1x9gknd 2236 6 separated separate VBN cord-010119-t1x9gknd 2236 7 from from IN cord-010119-t1x9gknd 2236 8 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 2236 9 . . . cord-010119-t1x9gknd 2237 1 Initial initial JJ cord-010119-t1x9gknd 2237 2 and and CC cord-010119-t1x9gknd 2237 3 output output NN cord-010119-t1x9gknd 2237 4 cell cell NN cord-010119-t1x9gknd 2237 5 counts count NNS cord-010119-t1x9gknd 2237 6 are be VBP cord-010119-t1x9gknd 2237 7 measured measure VBN cord-010119-t1x9gknd 2237 8 by by IN cord-010119-t1x9gknd 2237 9 a a DT cord-010119-t1x9gknd 2237 10 standard standard JJ cord-010119-t1x9gknd 2237 11 hematology hematology NN cord-010119-t1x9gknd 2237 12 analyzer analyzer NN cord-010119-t1x9gknd 2237 13 . . . cord-010119-t1x9gknd 2238 1 Results result NNS cord-010119-t1x9gknd 2238 2 / / SYM cord-010119-t1x9gknd 2238 3 Finding finding NN cord-010119-t1x9gknd 2238 4 : : : cord-010119-t1x9gknd 2239 1 In in IN cord-010119-t1x9gknd 2239 2 our -PRON- PRP$ cord-010119-t1x9gknd 2239 3 acoustic acoustic JJ cord-010119-t1x9gknd 2239 4 system system NN cord-010119-t1x9gknd 2239 5 , , , cord-010119-t1x9gknd 2239 6 lymphocyte lymphocyte NN cord-010119-t1x9gknd 2239 7 purity purity NN cord-010119-t1x9gknd 2239 8 ( ( -LRB- cord-010119-t1x9gknd 2239 9 % % NN cord-010119-t1x9gknd 2239 10 of of IN cord-010119-t1x9gknd 2239 11 total total JJ cord-010119-t1x9gknd 2239 12 WBCs wbc NNS cord-010119-t1x9gknd 2239 13 ) ) -RRB- cord-010119-t1x9gknd 2239 14 was be VBD cord-010119-t1x9gknd 2239 15 enriched enrich VBN cord-010119-t1x9gknd 2239 16 up up RP cord-010119-t1x9gknd 2239 17 to to TO cord-010119-t1x9gknd 2239 18 97 97 CD cord-010119-t1x9gknd 2239 19 % % NN cord-010119-t1x9gknd 2239 20 , , , cord-010119-t1x9gknd 2239 21 using use VBG cord-010119-t1x9gknd 2239 22 leukapheresis leukapheresis NN cord-010119-t1x9gknd 2239 23 product product NN cord-010119-t1x9gknd 2239 24 as as IN cord-010119-t1x9gknd 2239 25 the the DT cord-010119-t1x9gknd 2239 26 starting starting NN cord-010119-t1x9gknd 2239 27 material material NN cord-010119-t1x9gknd 2239 28 . . . cord-010119-t1x9gknd 2240 1 This this DT cord-010119-t1x9gknd 2240 2 enrichment enrichment NN cord-010119-t1x9gknd 2240 3 was be VBD cord-010119-t1x9gknd 2240 4 achieved achieve VBN cord-010119-t1x9gknd 2240 5 in in IN cord-010119-t1x9gknd 2240 6 a a DT cord-010119-t1x9gknd 2240 7 single single JJ cord-010119-t1x9gknd 2240 8 pass pass NN cord-010119-t1x9gknd 2240 9 through through IN cord-010119-t1x9gknd 2240 10 the the DT cord-010119-t1x9gknd 2240 11 device device NN cord-010119-t1x9gknd 2240 12 ( ( -LRB- cord-010119-t1x9gknd 2240 13 residence residence NN cord-010119-t1x9gknd 2240 14 time time NN cord-010119-t1x9gknd 2240 15 of of IN cord-010119-t1x9gknd 2240 16 1sec 1sec NNP cord-010119-t1x9gknd 2240 17 ) ) -RRB- cord-010119-t1x9gknd 2240 18 . . . cord-010119-t1x9gknd 2241 1 Total total JJ cord-010119-t1x9gknd 2241 2 lymphocyte lymphocyte NN cord-010119-t1x9gknd 2241 3 recovery recovery NN cord-010119-t1x9gknd 2241 4 was be VBD cord-010119-t1x9gknd 2241 5 43 43 CD cord-010119-t1x9gknd 2241 6 % % NN cord-010119-t1x9gknd 2241 7 and and CC cord-010119-t1x9gknd 2241 8 monocyte monocyte NNP cord-010119-t1x9gknd 2241 9 concentration concentration NN cord-010119-t1x9gknd 2241 10 was be VBD cord-010119-t1x9gknd 2241 11 reduced reduce VBN cord-010119-t1x9gknd 2241 12 76 76 CD cord-010119-t1x9gknd 2241 13 % % NN cord-010119-t1x9gknd 2241 14 . . . cord-010119-t1x9gknd 2242 1 Furthermore furthermore RB cord-010119-t1x9gknd 2242 2 , , , cord-010119-t1x9gknd 2242 3 in in IN cord-010119-t1x9gknd 2242 4 a a DT cord-010119-t1x9gknd 2242 5 two two CD cord-010119-t1x9gknd 2242 6 - - HYPH cord-010119-t1x9gknd 2242 7 pass pass NN cord-010119-t1x9gknd 2242 8 process process NN cord-010119-t1x9gknd 2242 9 platelets platelet NNS cord-010119-t1x9gknd 2242 10 were be VBD cord-010119-t1x9gknd 2242 11 reduced reduce VBN cord-010119-t1x9gknd 2242 12 by by IN cord-010119-t1x9gknd 2242 13 75 75 CD cord-010119-t1x9gknd 2242 14 % % NN cord-010119-t1x9gknd 2242 15 . . . cord-010119-t1x9gknd 2243 1 In in IN cord-010119-t1x9gknd 2243 2 a a DT cord-010119-t1x9gknd 2243 3 12-fold 12-fold CD cord-010119-t1x9gknd 2243 4 parallel parallel JJ cord-010119-t1x9gknd 2243 5 system system NN cord-010119-t1x9gknd 2243 6 we -PRON- PRP cord-010119-t1x9gknd 2243 7 tested test VBD cord-010119-t1x9gknd 2243 8 RBC RBC NNP cord-010119-t1x9gknd 2243 9 separation separation NN cord-010119-t1x9gknd 2243 10 from from IN cord-010119-t1x9gknd 2243 11 plasma plasma NN cord-010119-t1x9gknd 2243 12 and and CC cord-010119-t1x9gknd 2243 13 achieved achieve VBD cord-010119-t1x9gknd 2243 14 90 90 CD cord-010119-t1x9gknd 2243 15 % % NN cord-010119-t1x9gknd 2243 16 separation separation NN cord-010119-t1x9gknd 2243 17 at at IN cord-010119-t1x9gknd 2243 18 72ml 72ml CD cord-010119-t1x9gknd 2243 19 / / SYM cord-010119-t1x9gknd 2243 20 hr hr NN cord-010119-t1x9gknd 2243 21 . . . cord-010119-t1x9gknd 2244 1 Conclusion conclusion NN cord-010119-t1x9gknd 2244 2 : : : cord-010119-t1x9gknd 2245 1 Acoustic acoustic JJ cord-010119-t1x9gknd 2245 2 lymphocyte lymphocyte NN cord-010119-t1x9gknd 2245 3 enrichment enrichment NN cord-010119-t1x9gknd 2245 4 along along IN cord-010119-t1x9gknd 2245 5 with with IN cord-010119-t1x9gknd 2245 6 platelet platelet NN cord-010119-t1x9gknd 2245 7 depletion depletion NN cord-010119-t1x9gknd 2245 8 from from IN cord-010119-t1x9gknd 2245 9 standard standard JJ cord-010119-t1x9gknd 2245 10 blood blood NN cord-010119-t1x9gknd 2245 11 product product NN cord-010119-t1x9gknd 2245 12 was be VBD cord-010119-t1x9gknd 2245 13 demonstrated demonstrate VBN cord-010119-t1x9gknd 2245 14 for for IN cord-010119-t1x9gknd 2245 15 the the DT cord-010119-t1x9gknd 2245 16 first first JJ cord-010119-t1x9gknd 2245 17 time time NN cord-010119-t1x9gknd 2245 18 in in IN cord-010119-t1x9gknd 2245 19 plastic plastic JJ cord-010119-t1x9gknd 2245 20 microchannels microchannel NNS cord-010119-t1x9gknd 2245 21 . . . cord-010119-t1x9gknd 2246 1 Such such JJ cord-010119-t1x9gknd 2246 2 disposable disposable JJ cord-010119-t1x9gknd 2246 3 devices device NNS cord-010119-t1x9gknd 2246 4 are be VBP cord-010119-t1x9gknd 2246 5 suitable suitable JJ cord-010119-t1x9gknd 2246 6 for for IN cord-010119-t1x9gknd 2246 7 scale scale NN cord-010119-t1x9gknd 2246 8 up up RP cord-010119-t1x9gknd 2246 9 to to IN cord-010119-t1x9gknd 2246 10 clinical clinical JJ cord-010119-t1x9gknd 2246 11 bioprocessing bioprocessing NN cord-010119-t1x9gknd 2246 12 systems system NNS cord-010119-t1x9gknd 2246 13 . . . cord-010119-t1x9gknd 2247 1 Lymphocyte lymphocyte NN cord-010119-t1x9gknd 2247 2 purity purity NN cord-010119-t1x9gknd 2247 3 is be VBZ cord-010119-t1x9gknd 2247 4 comparable comparable JJ cord-010119-t1x9gknd 2247 5 to to IN cord-010119-t1x9gknd 2247 6 existing exist VBG cord-010119-t1x9gknd 2247 7 methods method NNS cord-010119-t1x9gknd 2247 8 with with IN cord-010119-t1x9gknd 2247 9 the the DT cord-010119-t1x9gknd 2247 10 advantage advantage NN cord-010119-t1x9gknd 2247 11 of of IN cord-010119-t1x9gknd 2247 12 monocyte monocyte NNP cord-010119-t1x9gknd 2247 13 and and CC cord-010119-t1x9gknd 2247 14 platelet platelet NN cord-010119-t1x9gknd 2247 15 depletion depletion NN cord-010119-t1x9gknd 2247 16 and and CC cord-010119-t1x9gknd 2247 17 potential potential NN cord-010119-t1x9gknd 2247 18 for for IN cord-010119-t1x9gknd 2247 19 an an DT cord-010119-t1x9gknd 2247 20 automated automate VBN cord-010119-t1x9gknd 2247 21 instrument instrument NN cord-010119-t1x9gknd 2247 22 . . . cord-010119-t1x9gknd 2247 23 _SP cord-010119-t1x9gknd 2248 1 Background Background NNP cord-010119-t1x9gknd 2248 2 / / SYM cord-010119-t1x9gknd 2248 3 Case Case NNP cord-010119-t1x9gknd 2248 4 Studies Studies NNPS cord-010119-t1x9gknd 2248 5 : : : cord-010119-t1x9gknd 2249 1 The the DT cord-010119-t1x9gknd 2249 2 use use NN cord-010119-t1x9gknd 2249 3 of of IN cord-010119-t1x9gknd 2249 4 natural natural JJ cord-010119-t1x9gknd 2249 5 killer killer NN cord-010119-t1x9gknd 2249 6 ( ( -LRB- cord-010119-t1x9gknd 2249 7 NK NK NNP cord-010119-t1x9gknd 2249 8 ) ) -RRB- cord-010119-t1x9gknd 2249 9 cells cell NNS cord-010119-t1x9gknd 2249 10 as as IN cord-010119-t1x9gknd 2249 11 a a DT cord-010119-t1x9gknd 2249 12 cellular cellular JJ cord-010119-t1x9gknd 2249 13 immunotherapy immunotherapy NN cord-010119-t1x9gknd 2249 14 has have VBZ cord-010119-t1x9gknd 2249 15 increased increase VBN cord-010119-t1x9gknd 2249 16 over over IN cord-010119-t1x9gknd 2249 17 the the DT cord-010119-t1x9gknd 2249 18 past past JJ cord-010119-t1x9gknd 2249 19 several several JJ cord-010119-t1x9gknd 2249 20 years year NNS cord-010119-t1x9gknd 2249 21 , , , cord-010119-t1x9gknd 2249 22 specifically specifically RB cord-010119-t1x9gknd 2249 23 their -PRON- PRP$ cord-010119-t1x9gknd 2249 24 use use NN cord-010119-t1x9gknd 2249 25 in in IN cord-010119-t1x9gknd 2249 26 patients patient NNS cord-010119-t1x9gknd 2249 27 with with IN cord-010119-t1x9gknd 2249 28 hematologic hematologic JJ cord-010119-t1x9gknd 2249 29 malignancies malignancy NNS cord-010119-t1x9gknd 2249 30 . . . cord-010119-t1x9gknd 2250 1 NK NK NNP cord-010119-t1x9gknd 2250 2 cells cell NNS cord-010119-t1x9gknd 2250 3 have have VBP cord-010119-t1x9gknd 2250 4 been be VBN cord-010119-t1x9gknd 2250 5 used use VBN cord-010119-t1x9gknd 2250 6 at at IN cord-010119-t1x9gknd 2250 7 our -PRON- PRP$ cord-010119-t1x9gknd 2250 8 institution institution NN cord-010119-t1x9gknd 2250 9 for for IN cord-010119-t1x9gknd 2250 10 the the DT cord-010119-t1x9gknd 2250 11 past past JJ cord-010119-t1x9gknd 2250 12 15 15 CD cord-010119-t1x9gknd 2250 13 years year NNS cord-010119-t1x9gknd 2250 14 . . . cord-010119-t1x9gknd 2251 1 Most Most JJS cord-010119-t1x9gknd 2251 2 patients patient NNS cord-010119-t1x9gknd 2251 3 have have VBP cord-010119-t1x9gknd 2251 4 a a DT cord-010119-t1x9gknd 2251 5 reaction reaction NN cord-010119-t1x9gknd 2251 6 with with IN cord-010119-t1x9gknd 2251 7 NK NK NNP cord-010119-t1x9gknd 2251 8 cell cell NN cord-010119-t1x9gknd 2251 9 infusion infusion NN cord-010119-t1x9gknd 2251 10 with with IN cord-010119-t1x9gknd 2251 11 some some DT cord-010119-t1x9gknd 2251 12 reactions reaction NNS cord-010119-t1x9gknd 2251 13 being be VBG cord-010119-t1x9gknd 2251 14 quite quite RB cord-010119-t1x9gknd 2251 15 severe severe JJ cord-010119-t1x9gknd 2251 16 . . . cord-010119-t1x9gknd 2252 1 We -PRON- PRP cord-010119-t1x9gknd 2252 2 retrospectively retrospectively RB cord-010119-t1x9gknd 2252 3 analyzed analyze VBD cord-010119-t1x9gknd 2252 4 the the DT cord-010119-t1x9gknd 2252 5 reactions reaction NNS cord-010119-t1x9gknd 2252 6 associated associate VBN cord-010119-t1x9gknd 2252 7 with with IN cord-010119-t1x9gknd 2252 8 NK NK NNP cord-010119-t1x9gknd 2252 9 cell cell NN cord-010119-t1x9gknd 2252 10 infusions infusion NNS cord-010119-t1x9gknd 2252 11 to to TO cord-010119-t1x9gknd 2252 12 help help VB cord-010119-t1x9gknd 2252 13 address address VB cord-010119-t1x9gknd 2252 14 why why WRB cord-010119-t1x9gknd 2252 15 some some DT cord-010119-t1x9gknd 2252 16 patients patient NNS cord-010119-t1x9gknd 2252 17 have have VBP cord-010119-t1x9gknd 2252 18 more more JJR cord-010119-t1x9gknd 2252 19 severe severe JJ cord-010119-t1x9gknd 2252 20 reactions reaction NNS cord-010119-t1x9gknd 2252 21 than than IN cord-010119-t1x9gknd 2252 22 others other NNS cord-010119-t1x9gknd 2252 23 . . . cord-010119-t1x9gknd 2253 1 Study Study NNP cord-010119-t1x9gknd 2253 2 Design Design NNP cord-010119-t1x9gknd 2253 3 / / SYM cord-010119-t1x9gknd 2253 4 Method method NN cord-010119-t1x9gknd 2253 5 : : : cord-010119-t1x9gknd 2254 1 Retrospective retrospective JJ cord-010119-t1x9gknd 2254 2 chart chart NN cord-010119-t1x9gknd 2254 3 review review NN cord-010119-t1x9gknd 2254 4 of of IN cord-010119-t1x9gknd 2254 5 NK NK NNP cord-010119-t1x9gknd 2254 6 cell cell NN cord-010119-t1x9gknd 2254 7 infusions infusion NNS cord-010119-t1x9gknd 2254 8 performed perform VBN cord-010119-t1x9gknd 2254 9 at at IN cord-010119-t1x9gknd 2254 10 our -PRON- PRP$ cord-010119-t1x9gknd 2254 11 institution institution NN cord-010119-t1x9gknd 2254 12 from from IN cord-010119-t1x9gknd 2254 13 9 9 CD cord-010119-t1x9gknd 2254 14 clinical clinical JJ cord-010119-t1x9gknd 2254 15 protocols protocol NNS cord-010119-t1x9gknd 2254 16 from from IN cord-010119-t1x9gknd 2254 17 2008 2008 CD cord-010119-t1x9gknd 2254 18 - - SYM cord-010119-t1x9gknd 2254 19 2016 2016 CD cord-010119-t1x9gknd 2254 20 . . . cord-010119-t1x9gknd 2255 1 An an DT cord-010119-t1x9gknd 2255 2 infusion infusion NN cord-010119-t1x9gknd 2255 3 reaction reaction NN cord-010119-t1x9gknd 2255 4 was be VBD cord-010119-t1x9gknd 2255 5 defined define VBN cord-010119-t1x9gknd 2255 6 as as IN cord-010119-t1x9gknd 2255 7 any any DT cord-010119-t1x9gknd 2255 8 symptom symptom NN cord-010119-t1x9gknd 2255 9 from from IN cord-010119-t1x9gknd 2255 10 the the DT cord-010119-t1x9gknd 2255 11 time time NN cord-010119-t1x9gknd 2255 12 of of IN cord-010119-t1x9gknd 2255 13 NK NK NNP cord-010119-t1x9gknd 2255 14 cell cell NN cord-010119-t1x9gknd 2255 15 infusion infusion NN cord-010119-t1x9gknd 2255 16 up up IN cord-010119-t1x9gknd 2255 17 to to TO cord-010119-t1x9gknd 2255 18 4 4 CD cord-010119-t1x9gknd 2255 19 hours hour NNS cord-010119-t1x9gknd 2255 20 afterwards afterwards RB cord-010119-t1x9gknd 2255 21 . . . cord-010119-t1x9gknd 2256 1 A a DT cord-010119-t1x9gknd 2256 2 severe severe JJ cord-010119-t1x9gknd 2256 3 reaction reaction NN cord-010119-t1x9gknd 2256 4 was be VBD cord-010119-t1x9gknd 2256 5 defined define VBN cord-010119-t1x9gknd 2256 6 as as IN cord-010119-t1x9gknd 2256 7 any any DT cord-010119-t1x9gknd 2256 8 symptom symptom NN cord-010119-t1x9gknd 2256 9 with with IN cord-010119-t1x9gknd 2256 10 Grade grade NN cord-010119-t1x9gknd 2256 11 3 3 CD cord-010119-t1x9gknd 2256 12 or or CC cord-010119-t1x9gknd 2256 13 higher high JJR cord-010119-t1x9gknd 2256 14 severity severity NN cord-010119-t1x9gknd 2256 15 ( ( -LRB- cord-010119-t1x9gknd 2256 16 graded grade VBN cord-010119-t1x9gknd 2256 17 on on IN cord-010119-t1x9gknd 2256 18 Common common JJ cord-010119-t1x9gknd 2256 19 Terminology terminology NN cord-010119-t1x9gknd 2256 20 Criteria Criteria NNP cord-010119-t1x9gknd 2256 21 for for IN cord-010119-t1x9gknd 2256 22 Adverse adverse JJ cord-010119-t1x9gknd 2256 23 Events event NNS cord-010119-t1x9gknd 2256 24 - - HYPH cord-010119-t1x9gknd 2256 25 CTCAE CTCAE NNP cord-010119-t1x9gknd 2256 26 ) ) -RRB- cord-010119-t1x9gknd 2256 27 . . . cord-010119-t1x9gknd 2257 1 Preliminary preliminary JJ cord-010119-t1x9gknd 2257 2 data datum NNS cord-010119-t1x9gknd 2257 3 was be VBD cord-010119-t1x9gknd 2257 4 analyzed analyze VBN cord-010119-t1x9gknd 2257 5 using use VBG cord-010119-t1x9gknd 2257 6 R R NNP cord-010119-t1x9gknd 2257 7 3.3.1 3.3.1 CD cord-010119-t1x9gknd 2257 8 . . . cord-010119-t1x9gknd 2258 1 Two two CD cord-010119-t1x9gknd 2258 2 major major JJ cord-010119-t1x9gknd 2258 3 endpoints endpoint NNS cord-010119-t1x9gknd 2258 4 of of IN cord-010119-t1x9gknd 2258 5 interest interest NN cord-010119-t1x9gknd 2258 6 were be VBD cord-010119-t1x9gknd 2258 7 : : : cord-010119-t1x9gknd 2258 8 1 1 LS cord-010119-t1x9gknd 2258 9 ) ) -RRB- cord-010119-t1x9gknd 2258 10 infusion infusion NN cord-010119-t1x9gknd 2258 11 reaction reaction NN cord-010119-t1x9gknd 2258 12 with with IN cord-010119-t1x9gknd 2258 13 any any DT cord-010119-t1x9gknd 2258 14 symptom symptom NN cord-010119-t1x9gknd 2258 15 and and CC cord-010119-t1x9gknd 2258 16 2 2 LS cord-010119-t1x9gknd 2258 17 ) ) -RRB- cord-010119-t1x9gknd 2258 18 severe severe JJ cord-010119-t1x9gknd 2258 19 infusion infusion NN cord-010119-t1x9gknd 2258 20 reaction reaction NN cord-010119-t1x9gknd 2258 21 . . . cord-010119-t1x9gknd 2259 1 To to TO cord-010119-t1x9gknd 2259 2 numerically numerically RB cord-010119-t1x9gknd 2259 3 summarize summarize VB cord-010119-t1x9gknd 2259 4 the the DT cord-010119-t1x9gknd 2259 5 association association NN cord-010119-t1x9gknd 2259 6 of of IN cord-010119-t1x9gknd 2259 7 continuous continuous JJ cord-010119-t1x9gknd 2259 8 variables variable NNS cord-010119-t1x9gknd 2259 9 with with IN cord-010119-t1x9gknd 2259 10 our -PRON- PRP$ cord-010119-t1x9gknd 2259 11 endpoints endpoint NNS cord-010119-t1x9gknd 2259 12 , , , cord-010119-t1x9gknd 2259 13 the the DT cord-010119-t1x9gknd 2259 14 median median NN cord-010119-t1x9gknd 2259 15 , , , cord-010119-t1x9gknd 2259 16 ( ( -LRB- cord-010119-t1x9gknd 2259 17 range range NN cord-010119-t1x9gknd 2259 18 ) ) -RRB- cord-010119-t1x9gknd 2259 19 and and CC cord-010119-t1x9gknd 2259 20 interquartile interquartile JJ cord-010119-t1x9gknd 2259 21 range range NN cord-010119-t1x9gknd 2259 22 ( ( -LRB- cord-010119-t1x9gknd 2259 23 IQR IQR NNP cord-010119-t1x9gknd 2259 24 ) ) -RRB- cord-010119-t1x9gknd 2259 25 were be VBD cord-010119-t1x9gknd 2259 26 used use VBN cord-010119-t1x9gknd 2259 27 . . . cord-010119-t1x9gknd 2260 1 A a DT cord-010119-t1x9gknd 2260 2 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 2260 3 test test NN cord-010119-t1x9gknd 2260 4 was be VBD cord-010119-t1x9gknd 2260 5 performed perform VBN cord-010119-t1x9gknd 2260 6 to to TO cord-010119-t1x9gknd 2260 7 test test VB cord-010119-t1x9gknd 2260 8 the the DT cord-010119-t1x9gknd 2260 9 association association NN cord-010119-t1x9gknd 2260 10 between between IN cord-010119-t1x9gknd 2260 11 the the DT cord-010119-t1x9gknd 2260 12 continuous continuous JJ cord-010119-t1x9gknd 2260 13 variables variable NNS cord-010119-t1x9gknd 2260 14 and and CC cord-010119-t1x9gknd 2260 15 our -PRON- PRP$ cord-010119-t1x9gknd 2260 16 end end NN cord-010119-t1x9gknd 2260 17 points point NNS cord-010119-t1x9gknd 2260 18 . . . cord-010119-t1x9gknd 2261 1 A a DT cord-010119-t1x9gknd 2261 2 Chi Chi NNP cord-010119-t1x9gknd 2261 3 - - HYPH cord-010119-t1x9gknd 2261 4 Square Square NNP cord-010119-t1x9gknd 2261 5 test test NN cord-010119-t1x9gknd 2261 6 was be VBD cord-010119-t1x9gknd 2261 7 used use VBN cord-010119-t1x9gknd 2261 8 to to TO cord-010119-t1x9gknd 2261 9 test test VB cord-010119-t1x9gknd 2261 10 the the DT cord-010119-t1x9gknd 2261 11 association association NN cord-010119-t1x9gknd 2261 12 between between IN cord-010119-t1x9gknd 2261 13 categorical categorical JJ cord-010119-t1x9gknd 2261 14 variables variable NNS cord-010119-t1x9gknd 2261 15 and and CC cord-010119-t1x9gknd 2261 16 our -PRON- PRP$ cord-010119-t1x9gknd 2261 17 endpoints endpoint NNS cord-010119-t1x9gknd 2261 18 of of IN cord-010119-t1x9gknd 2261 19 interest interest NN cord-010119-t1x9gknd 2261 20 . . . cord-010119-t1x9gknd 2262 1 Results/ Results/ . cord-010119-t1x9gknd 2263 1 Finding find VBG cord-010119-t1x9gknd 2263 2 : : : cord-010119-t1x9gknd 2263 3 There there EX cord-010119-t1x9gknd 2263 4 were be VBD cord-010119-t1x9gknd 2263 5 a a DT cord-010119-t1x9gknd 2263 6 total total NN cord-010119-t1x9gknd 2263 7 of of IN cord-010119-t1x9gknd 2263 8 127 127 CD cord-010119-t1x9gknd 2263 9 NK NK NNP cord-010119-t1x9gknd 2263 10 cell cell NN cord-010119-t1x9gknd 2263 11 infusions infusion NNS cord-010119-t1x9gknd 2263 12 . . . cord-010119-t1x9gknd 2264 1 There there EX cord-010119-t1x9gknd 2264 2 were be VBD cord-010119-t1x9gknd 2264 3 119 119 CD cord-010119-t1x9gknd 2264 4 ( ( -LRB- cord-010119-t1x9gknd 2264 5 94 94 CD cord-010119-t1x9gknd 2264 6 % % NN cord-010119-t1x9gknd 2264 7 ) ) -RRB- cord-010119-t1x9gknd 2264 8 patients patient NNS cord-010119-t1x9gknd 2264 9 with with IN cord-010119-t1x9gknd 2264 10 an an DT cord-010119-t1x9gknd 2264 11 infusion infusion NN cord-010119-t1x9gknd 2264 12 reaction reaction NN cord-010119-t1x9gknd 2264 13 of of IN cord-010119-t1x9gknd 2264 14 any any DT cord-010119-t1x9gknd 2264 15 symptom symptom NN cord-010119-t1x9gknd 2264 16 and and CC cord-010119-t1x9gknd 2264 17 there there EX cord-010119-t1x9gknd 2264 18 were be VBD cord-010119-t1x9gknd 2264 19 37 37 CD cord-010119-t1x9gknd 2264 20 ( ( -LRB- cord-010119-t1x9gknd 2264 21 29 29 CD cord-010119-t1x9gknd 2264 22 % % NN cord-010119-t1x9gknd 2264 23 ) ) -RRB- cord-010119-t1x9gknd 2264 24 patients patient NNS cord-010119-t1x9gknd 2264 25 with with IN cord-010119-t1x9gknd 2264 26 a a DT cord-010119-t1x9gknd 2264 27 severe severe JJ cord-010119-t1x9gknd 2264 28 reaction reaction NN cord-010119-t1x9gknd 2264 29 . . . cord-010119-t1x9gknd 2265 1 Infusion infusion NN cord-010119-t1x9gknd 2265 2 rate rate NN cord-010119-t1x9gknd 2265 3 ( ( -LRB- cord-010119-t1x9gknd 2265 4 mL ml NN cord-010119-t1x9gknd 2265 5 / / SYM cord-010119-t1x9gknd 2265 6 min min NN cord-010119-t1x9gknd 2265 7 ) ) -RRB- cord-010119-t1x9gknd 2265 8 was be VBD cord-010119-t1x9gknd 2265 9 similar similar JJ cord-010119-t1x9gknd 2265 10 among among IN cord-010119-t1x9gknd 2265 11 those those DT cord-010119-t1x9gknd 2265 12 with with IN cord-010119-t1x9gknd 2265 13 any any DT cord-010119-t1x9gknd 2265 14 reaction reaction NN cord-010119-t1x9gknd 2265 15 ( ( -LRB- cord-010119-t1x9gknd 2265 16 median52.55 median52.55 NN cord-010119-t1x9gknd 2265 17 , , , cord-010119-t1x9gknd 2265 18 p50.42 p50.42 NNP cord-010119-t1x9gknd 2265 19 ) ) -RRB- cord-010119-t1x9gknd 2265 20 and and CC cord-010119-t1x9gknd 2265 21 those those DT cord-010119-t1x9gknd 2265 22 with with IN cord-010119-t1x9gknd 2265 23 severe severe JJ cord-010119-t1x9gknd 2265 24 reaction reaction NN cord-010119-t1x9gknd 2265 25 ( ( -LRB- cord-010119-t1x9gknd 2265 26 median52.52 median52.52 NNP cord-010119-t1x9gknd 2265 27 , , , cord-010119-t1x9gknd 2265 28 p5 p5 NNP cord-010119-t1x9gknd 2265 29 0.42 0.42 CD cord-010119-t1x9gknd 2265 30 ) ) -RRB- cord-010119-t1x9gknd 2265 31 . . . cord-010119-t1x9gknd 2266 1 Infusion infusion NN cord-010119-t1x9gknd 2266 2 rate rate NN cord-010119-t1x9gknd 2266 3 ( ( -LRB- cord-010119-t1x9gknd 2266 4 mL ml NN cord-010119-t1x9gknd 2266 5 / / SYM cord-010119-t1x9gknd 2266 6 min min NN cord-010119-t1x9gknd 2266 7 / / SYM cord-010119-t1x9gknd 2266 8 kg kg NNP cord-010119-t1x9gknd 2266 9 ) ) -RRB- cord-010119-t1x9gknd 2266 10 was be VBD cord-010119-t1x9gknd 2266 11 also also RB cord-010119-t1x9gknd 2266 12 similar similar JJ cord-010119-t1x9gknd 2266 13 among among IN cord-010119-t1x9gknd 2266 14 those those DT cord-010119-t1x9gknd 2266 15 with with IN cord-010119-t1x9gknd 2266 16 any any DT cord-010119-t1x9gknd 2266 17 reaction reaction NN cord-010119-t1x9gknd 2266 18 ( ( -LRB- cord-010119-t1x9gknd 2266 19 median50.03 median50.03 NNP cord-010119-t1x9gknd 2266 20 , , , cord-010119-t1x9gknd 2266 21 p50.43 p50.43 XX cord-010119-t1x9gknd 2266 22 ) ) -RRB- cord-010119-t1x9gknd 2266 23 and and CC cord-010119-t1x9gknd 2266 24 those those DT cord-010119-t1x9gknd 2266 25 with with IN cord-010119-t1x9gknd 2266 26 severe severe JJ cord-010119-t1x9gknd 2266 27 reaction reaction NN cord-010119-t1x9gknd 2266 28 ( ( -LRB- cord-010119-t1x9gknd 2266 29 median50.03 median50.03 NNP cord-010119-t1x9gknd 2266 30 , , , cord-010119-t1x9gknd 2266 31 p50.15 p50.15 VB cord-010119-t1x9gknd 2266 32 respectively respectively RB cord-010119-t1x9gknd 2266 33 ) ) -RRB- cord-010119-t1x9gknd 2266 34 . . . cord-010119-t1x9gknd 2267 1 Incubation Incubation NNP cord-010119-t1x9gknd 2267 2 of of IN cord-010119-t1x9gknd 2267 3 NK NK NNP cord-010119-t1x9gknd 2267 4 cell cell NN cord-010119-t1x9gknd 2267 5 product product NN cord-010119-t1x9gknd 2267 6 overnight overnight RB cord-010119-t1x9gknd 2267 7 in in IN cord-010119-t1x9gknd 2268 1 IL-2 IL-2 NNP cord-010119-t1x9gknd 2268 2 vs vs IN cord-010119-t1x9gknd 2268 3 IL-15 IL-15 NNP cord-010119-t1x9gknd 2268 4 had have VBD cord-010119-t1x9gknd 2268 5 similar similar JJ cord-010119-t1x9gknd 2268 6 reaction reaction NN cord-010119-t1x9gknd 2268 7 rates rate NNS cord-010119-t1x9gknd 2268 8 for for IN cord-010119-t1x9gknd 2268 9 those those DT cord-010119-t1x9gknd 2268 10 with with IN cord-010119-t1x9gknd 2268 11 any any DT cord-010119-t1x9gknd 2268 12 symptom symptom NN cord-010119-t1x9gknd 2268 13 ( ( -LRB- cord-010119-t1x9gknd 2268 14 88 88 CD cord-010119-t1x9gknd 2268 15 % % NN cord-010119-t1x9gknd 2268 16 had have VBD cord-010119-t1x9gknd 2268 17 reaction reaction NN cord-010119-t1x9gknd 2268 18 with with IN cord-010119-t1x9gknd 2268 19 IL-2 IL-2 NNP cord-010119-t1x9gknd 2268 20 , , , cord-010119-t1x9gknd 2268 21 86 86 CD cord-010119-t1x9gknd 2268 22 % % NN cord-010119-t1x9gknd 2268 23 had have VBD cord-010119-t1x9gknd 2268 24 reaction reaction NN cord-010119-t1x9gknd 2268 25 with with IN cord-010119-t1x9gknd 2268 26 IL-15 IL-15 NNP cord-010119-t1x9gknd 2268 27 , , , cord-010119-t1x9gknd 2268 28 p50.94 p50.94 NNP cord-010119-t1x9gknd 2268 29 ) ) -RRB- cord-010119-t1x9gknd 2268 30 and and CC cord-010119-t1x9gknd 2268 31 those those DT cord-010119-t1x9gknd 2268 32 with with IN cord-010119-t1x9gknd 2268 33 severe severe JJ cord-010119-t1x9gknd 2268 34 reaction reaction NN cord-010119-t1x9gknd 2268 35 ( ( -LRB- cord-010119-t1x9gknd 2268 36 28 28 CD cord-010119-t1x9gknd 2268 37 % % NN cord-010119-t1x9gknd 2268 38 had have VBD cord-010119-t1x9gknd 2268 39 severe severe JJ cord-010119-t1x9gknd 2268 40 reaction reaction NN cord-010119-t1x9gknd 2268 41 with with IN cord-010119-t1x9gknd 2268 42 IL-2 IL-2 NNP cord-010119-t1x9gknd 2268 43 , , , cord-010119-t1x9gknd 2268 44 24 24 CD cord-010119-t1x9gknd 2268 45 % % NN cord-010119-t1x9gknd 2268 46 had have VBD cord-010119-t1x9gknd 2268 47 severe severe JJ cord-010119-t1x9gknd 2268 48 reaction reaction NN cord-010119-t1x9gknd 2268 49 with with IN cord-010119-t1x9gknd 2268 50 IL-15 IL-15 NNP cord-010119-t1x9gknd 2268 51 , , , cord-010119-t1x9gknd 2268 52 p50.80 p50.80 NNP cord-010119-t1x9gknd 2268 53 ) ) -RRB- cord-010119-t1x9gknd 2268 54 . . . cord-010119-t1x9gknd 2269 1 Patients patient NNS cord-010119-t1x9gknd 2269 2 with with IN cord-010119-t1x9gknd 2269 3 severe severe JJ cord-010119-t1x9gknd 2269 4 reaction reaction NN cord-010119-t1x9gknd 2269 5 had have VBD cord-010119-t1x9gknd 2269 6 a a DT cord-010119-t1x9gknd 2269 7 higher high JJR cord-010119-t1x9gknd 2269 8 calculated calculate VBN cord-010119-t1x9gknd 2269 9 monocyte monocyte NNP cord-010119-t1x9gknd 2269 10 dose dose NN cord-010119-t1x9gknd 2269 11 ( ( -LRB- cord-010119-t1x9gknd 2269 12 monocytes monocyte NNS cord-010119-t1x9gknd 2269 13 / / SYM cord-010119-t1x9gknd 2269 14 kg kg NNP cord-010119-t1x9gknd 2269 15 ) ) -RRB- cord-010119-t1x9gknd 2269 16 in in IN cord-010119-t1x9gknd 2269 17 the the DT cord-010119-t1x9gknd 2269 18 NK NK NNP cord-010119-t1x9gknd 2269 19 cell cell NN cord-010119-t1x9gknd 2269 20 product product NN cord-010119-t1x9gknd 2269 21 ( ( -LRB- cord-010119-t1x9gknd 2270 1 median52.44 median52.44 NNS cord-010119-t1x9gknd 2271 1 x x LS cord-010119-t1x9gknd 2271 2 107 107 CD cord-010119-t1x9gknd 2271 3 ) ) -RRB- cord-010119-t1x9gknd 2272 1 versus versus IN cord-010119-t1x9gknd 2272 2 those those DT cord-010119-t1x9gknd 2272 3 without without IN cord-010119-t1x9gknd 2272 4 ( ( -LRB- cord-010119-t1x9gknd 2272 5 median51.92 median51.92 NNP cord-010119-t1x9gknd 2272 6 x x SYM cord-010119-t1x9gknd 2272 7 107 107 CD cord-010119-t1x9gknd 2272 8 , , , cord-010119-t1x9gknd 2272 9 p50.02 p50.02 NNP cord-010119-t1x9gknd 2272 10 ) ) -RRB- cord-010119-t1x9gknd 2272 11 . . . cord-010119-t1x9gknd 2273 1 Conclusion conclusion NN cord-010119-t1x9gknd 2273 2 : : : cord-010119-t1x9gknd 2274 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2274 2 preliminary preliminary JJ cord-010119-t1x9gknd 2274 3 data data NN cord-010119-t1x9gknd 2274 4 analysis analysis NN cord-010119-t1x9gknd 2274 5 reveals reveal VBZ cord-010119-t1x9gknd 2274 6 that that IN cord-010119-t1x9gknd 2274 7 a a DT cord-010119-t1x9gknd 2274 8 higher high JJR cord-010119-t1x9gknd 2274 9 number number NN cord-010119-t1x9gknd 2274 10 of of IN cord-010119-t1x9gknd 2274 11 monocytes monocyte NNS cord-010119-t1x9gknd 2274 12 in in IN cord-010119-t1x9gknd 2274 13 the the DT cord-010119-t1x9gknd 2274 14 NK NK NNP cord-010119-t1x9gknd 2274 15 cell cell NN cord-010119-t1x9gknd 2274 16 product product NN cord-010119-t1x9gknd 2274 17 may may MD cord-010119-t1x9gknd 2274 18 contribute contribute VB cord-010119-t1x9gknd 2274 19 to to IN cord-010119-t1x9gknd 2274 20 severe severe JJ cord-010119-t1x9gknd 2274 21 infusion infusion NN cord-010119-t1x9gknd 2274 22 reactions reaction NNS cord-010119-t1x9gknd 2274 23 , , , cord-010119-t1x9gknd 2274 24 causing cause VBG cord-010119-t1x9gknd 2274 25 patients patient NNS cord-010119-t1x9gknd 2274 26 to to TO cord-010119-t1x9gknd 2274 27 have have VB cord-010119-t1x9gknd 2274 28 a a DT cord-010119-t1x9gknd 2274 29 grade grade NN cord-010119-t1x9gknd 2274 30 3 3 CD cord-010119-t1x9gknd 2274 31 or or CC cord-010119-t1x9gknd 2274 32 higher high JJR cord-010119-t1x9gknd 2274 33 symptom symptom NN cord-010119-t1x9gknd 2274 34 . . . cord-010119-t1x9gknd 2275 1 Limitations limitation NNS cord-010119-t1x9gknd 2275 2 to to IN cord-010119-t1x9gknd 2275 3 this this DT cord-010119-t1x9gknd 2275 4 study study NN cord-010119-t1x9gknd 2275 5 include include VB cord-010119-t1x9gknd 2275 6 this this DT cord-010119-t1x9gknd 2275 7 was be VBD cord-010119-t1x9gknd 2275 8 a a DT cord-010119-t1x9gknd 2275 9 retrospective retrospective JJ cord-010119-t1x9gknd 2275 10 review review NN cord-010119-t1x9gknd 2275 11 at at IN cord-010119-t1x9gknd 2275 12 a a DT cord-010119-t1x9gknd 2275 13 single single JJ cord-010119-t1x9gknd 2275 14 institution institution NN cord-010119-t1x9gknd 2275 15 . . . cord-010119-t1x9gknd 2276 1 A a DT cord-010119-t1x9gknd 2276 2 Streamlined Streamlined NNP cord-010119-t1x9gknd 2276 3 Mixed Mixed NNP cord-010119-t1x9gknd 2276 4 Lymphocyte lymphocyte NN cord-010119-t1x9gknd 2276 5 Reaction reaction NN cord-010119-t1x9gknd 2276 6 ( ( -LRB- cord-010119-t1x9gknd 2276 7 MLR MLR NNP cord-010119-t1x9gknd 2276 8 ) ) -RRB- cord-010119-t1x9gknd 2276 9 Assay Assay NNP cord-010119-t1x9gknd 2276 10 for for IN cord-010119-t1x9gknd 2276 11 Evaluation Evaluation NNP cord-010119-t1x9gknd 2276 12 of of IN cord-010119-t1x9gknd 2276 13 Human Human NNP cord-010119-t1x9gknd 2276 14 Mesenchymal Mesenchymal NNP cord-010119-t1x9gknd 2276 15 Stem Stem NNP cord-010119-t1x9gknd 2276 16 Cell cell NN cord-010119-t1x9gknd 2276 17 Immunomodulation Immunomodulation NNP cord-010119-t1x9gknd 2276 18 Activity Activity NNP cord-010119-t1x9gknd 2276 19 Christopher Christopher NNP cord-010119-t1x9gknd 2276 20 P P NNP cord-010119-t1x9gknd 2276 21 Delavan Delavan NNP cord-010119-t1x9gknd 2276 22 1 1 CD cord-010119-t1x9gknd 2276 23 , , , cord-010119-t1x9gknd 2276 24 Maryanne Maryanne NNP cord-010119-t1x9gknd 2276 25 C C NNP cord-010119-t1x9gknd 2276 26 Herzig Herzig NNP cord-010119-t1x9gknd 2276 27 * * NFP cord-010119-t1x9gknd 2276 28 1 1 CD cord-010119-t1x9gknd 2276 29 , , , cord-010119-t1x9gknd 2276 30 Barbara Barbara NNP cord-010119-t1x9gknd 2276 31 A A NNP cord-010119-t1x9gknd 2276 32 Christy Christy NNP cord-010119-t1x9gknd 2276 33 1 1 CD cord-010119-t1x9gknd 2276 34 , , , cord-010119-t1x9gknd 2276 35 James James NNP cord-010119-t1x9gknd 2276 36 A. A. NNP cord-010119-t1x9gknd 2276 37 Bynum Bynum NNP cord-010119-t1x9gknd 2276 38 2 2 CD cord-010119-t1x9gknd 2276 39 and and CC cord-010119-t1x9gknd 2276 40 Andrew Andrew NNP cord-010119-t1x9gknd 2276 41 P P NNP cord-010119-t1x9gknd 2276 42 Cap Cap NNP cord-010119-t1x9gknd 2276 43 2 2 CD cord-010119-t1x9gknd 2276 44 . . . cord-010119-t1x9gknd 2277 1 1 1 LS cord-010119-t1x9gknd 2278 1 US US NNP cord-010119-t1x9gknd 2278 2 Army Army NNP cord-010119-t1x9gknd 2278 3 Institute Institute NNP cord-010119-t1x9gknd 2278 4 of of IN cord-010119-t1x9gknd 2278 5 Surgical Surgical NNP cord-010119-t1x9gknd 2278 6 Research Research NNP cord-010119-t1x9gknd 2278 7 , , , cord-010119-t1x9gknd 2278 8 2 2 CD cord-010119-t1x9gknd 2278 9 U.S. U.S. NNP cord-010119-t1x9gknd 2278 10 Army Army NNP cord-010119-t1x9gknd 2278 11 Institute Institute NNP cord-010119-t1x9gknd 2278 12 of of IN cord-010119-t1x9gknd 2278 13 Surgical Surgical NNP cord-010119-t1x9gknd 2278 14 Research Research NNP cord-010119-t1x9gknd 2278 15 Background Background NNP cord-010119-t1x9gknd 2278 16 / / SYM cord-010119-t1x9gknd 2278 17 Case Case NNP cord-010119-t1x9gknd 2278 18 Studies Studies NNPS cord-010119-t1x9gknd 2278 19 : : : cord-010119-t1x9gknd 2278 20 Mesenchymal Mesenchymal NNP cord-010119-t1x9gknd 2278 21 Stem Stem NNP cord-010119-t1x9gknd 2278 22 Cells cell NNS cord-010119-t1x9gknd 2278 23 ( ( -LRB- cord-010119-t1x9gknd 2278 24 MSC MSC NNP cord-010119-t1x9gknd 2278 25 ) ) -RRB- cord-010119-t1x9gknd 2278 26 have have VBP cord-010119-t1x9gknd 2278 27 been be VBN cord-010119-t1x9gknd 2278 28 investigated investigate VBN cord-010119-t1x9gknd 2278 29 for for IN cord-010119-t1x9gknd 2278 30 treatment treatment NN cord-010119-t1x9gknd 2278 31 of of IN cord-010119-t1x9gknd 2278 32 acute acute JJ cord-010119-t1x9gknd 2278 33 respiratory respiratory JJ cord-010119-t1x9gknd 2278 34 distress distress NN cord-010119-t1x9gknd 2278 35 syndrome syndrome NN cord-010119-t1x9gknd 2278 36 ( ( -LRB- cord-010119-t1x9gknd 2278 37 ARDS ARDS NNP cord-010119-t1x9gknd 2278 38 ) ) -RRB- cord-010119-t1x9gknd 2278 39 , , , cord-010119-t1x9gknd 2278 40 graft graft NN cord-010119-t1x9gknd 2278 41 versus versus IN cord-010119-t1x9gknd 2278 42 host host NN cord-010119-t1x9gknd 2278 43 disease disease NN cord-010119-t1x9gknd 2278 44 ( ( -LRB- cord-010119-t1x9gknd 2278 45 GVHD GVHD NNP cord-010119-t1x9gknd 2278 46 ) ) -RRB- cord-010119-t1x9gknd 2278 47 , , , cord-010119-t1x9gknd 2278 48 wound wind VBD cord-010119-t1x9gknd 2278 49 healing healing NN cord-010119-t1x9gknd 2278 50 and and CC cord-010119-t1x9gknd 2278 51 trauma trauma NN cord-010119-t1x9gknd 2278 52 . . . cord-010119-t1x9gknd 2279 1 A a DT cord-010119-t1x9gknd 2279 2 consensus consensus NN cord-010119-t1x9gknd 2279 3 is be VBZ cord-010119-t1x9gknd 2279 4 building build VBG cord-010119-t1x9gknd 2279 5 that that IN cord-010119-t1x9gknd 2279 6 the the DT cord-010119-t1x9gknd 2279 7 immunomodulation immunomodulation NN cord-010119-t1x9gknd 2279 8 by by IN cord-010119-t1x9gknd 2279 9 MSCs mscs NN cord-010119-t1x9gknd 2279 10 is be VBZ cord-010119-t1x9gknd 2279 11 key key JJ cord-010119-t1x9gknd 2279 12 to to IN cord-010119-t1x9gknd 2279 13 their -PRON- PRP$ cord-010119-t1x9gknd 2279 14 therapeutic therapeutic JJ cord-010119-t1x9gknd 2279 15 potential potential NN cord-010119-t1x9gknd 2279 16 . . . cord-010119-t1x9gknd 2280 1 MSCs msc NNS cord-010119-t1x9gknd 2280 2 suppress suppress VBP cord-010119-t1x9gknd 2280 3 peripheral peripheral JJ cord-010119-t1x9gknd 2280 4 blood blood NN cord-010119-t1x9gknd 2280 5 mononuclear mononuclear NN cord-010119-t1x9gknd 2280 6 cells cell NNS cord-010119-t1x9gknd 2280 7 ( ( -LRB- cord-010119-t1x9gknd 2280 8 PBMC PBMC NNP cord-010119-t1x9gknd 2280 9 ) ) -RRB- cord-010119-t1x9gknd 2280 10 proliferation proliferation NN cord-010119-t1x9gknd 2280 11 in in IN cord-010119-t1x9gknd 2280 12 vitro vitro FW cord-010119-t1x9gknd 2280 13 , , , cord-010119-t1x9gknd 2280 14 suggesting suggest VBG cord-010119-t1x9gknd 2280 15 a a DT cord-010119-t1x9gknd 2280 16 correlation correlation NN cord-010119-t1x9gknd 2280 17 for for IN cord-010119-t1x9gknd 2280 18 suppressing suppress VBG cord-010119-t1x9gknd 2280 19 PBMC PBMC NNP cord-010119-t1x9gknd 2280 20 inflammatory inflammatory JJ cord-010119-t1x9gknd 2280 21 responses response NNS cord-010119-t1x9gknd 2280 22 in in IN cord-010119-t1x9gknd 2280 23 vivo vivo NN cord-010119-t1x9gknd 2280 24 . . . cord-010119-t1x9gknd 2281 1 Current current JJ cord-010119-t1x9gknd 2281 2 mixed mixed JJ cord-010119-t1x9gknd 2281 3 lymphocyte lymphocyte NN cord-010119-t1x9gknd 2281 4 reaction reaction NN cord-010119-t1x9gknd 2282 1 ( ( -LRB- cord-010119-t1x9gknd 2282 2 MLR MLR NNP cord-010119-t1x9gknd 2282 3 ) ) -RRB- cord-010119-t1x9gknd 2282 4 assays assay NNS cord-010119-t1x9gknd 2282 5 generally generally RB cord-010119-t1x9gknd 2282 6 rely rely VBP cord-010119-t1x9gknd 2282 7 on on IN cord-010119-t1x9gknd 2282 8 either either DT cord-010119-t1x9gknd 2282 9 direct direct JJ cord-010119-t1x9gknd 2282 10 co co NN cord-010119-t1x9gknd 2282 11 - - NN cord-010119-t1x9gknd 2282 12 culture culture JJ cord-010119-t1x9gknd 2282 13 or or CC cord-010119-t1x9gknd 2282 14 indirect indirect JJ cord-010119-t1x9gknd 2282 15 culture culture NN cord-010119-t1x9gknd 2282 16 using use VBG cord-010119-t1x9gknd 2282 17 transwell transwell NNP cord-010119-t1x9gknd 2282 18 systems system NNS cord-010119-t1x9gknd 2282 19 for for IN cord-010119-t1x9gknd 2282 20 monitoring monitor VBG cord-010119-t1x9gknd 2282 21 the the DT cord-010119-t1x9gknd 2282 22 proliferation proliferation NN cord-010119-t1x9gknd 2282 23 of of IN cord-010119-t1x9gknd 2282 24 isolated isolate VBN cord-010119-t1x9gknd 2282 25 PBMCs pbmc NNS cord-010119-t1x9gknd 2282 26 in in IN cord-010119-t1x9gknd 2282 27 the the DT cord-010119-t1x9gknd 2282 28 presence presence NN cord-010119-t1x9gknd 2282 29 of of IN cord-010119-t1x9gknd 2282 30 mitotically mitotically RB cord-010119-t1x9gknd 2282 31 inactive inactive JJ cord-010119-t1x9gknd 2282 32 MSCs msc NNS cord-010119-t1x9gknd 2282 33 . . . cord-010119-t1x9gknd 2283 1 In in IN cord-010119-t1x9gknd 2283 2 the the DT cord-010119-t1x9gknd 2283 3 study study NN cord-010119-t1x9gknd 2283 4 detailed detail VBN cord-010119-t1x9gknd 2283 5 here here RB cord-010119-t1x9gknd 2283 6 , , , cord-010119-t1x9gknd 2283 7 MSCs msc NNS cord-010119-t1x9gknd 2283 8 are be VBP cord-010119-t1x9gknd 2283 9 analyzed analyze VBN cord-010119-t1x9gknd 2283 10 in in IN cord-010119-t1x9gknd 2283 11 a a DT cord-010119-t1x9gknd 2283 12 direct direct JJ cord-010119-t1x9gknd 2283 13 co co NN cord-010119-t1x9gknd 2283 14 - - NN cord-010119-t1x9gknd 2283 15 culture culture NN cord-010119-t1x9gknd 2283 16 with with IN cord-010119-t1x9gknd 2283 17 PBMCs pbmc NNS cord-010119-t1x9gknd 2283 18 using use VBG cord-010119-t1x9gknd 2283 19 a a DT cord-010119-t1x9gknd 2283 20 luminescent luminescent JJ cord-010119-t1x9gknd 2283 21 ATP ATP NNP cord-010119-t1x9gknd 2283 22 assay assay NN cord-010119-t1x9gknd 2283 23 . . . cord-010119-t1x9gknd 2284 1 Study Study NNP cord-010119-t1x9gknd 2284 2 Design Design NNP cord-010119-t1x9gknd 2284 3 / / SYM cord-010119-t1x9gknd 2284 4 Method method NN cord-010119-t1x9gknd 2284 5 : : : cord-010119-t1x9gknd 2284 6 Blood blood NN cord-010119-t1x9gknd 2284 7 was be VBD cord-010119-t1x9gknd 2284 8 obtained obtain VBN cord-010119-t1x9gknd 2284 9 from from IN cord-010119-t1x9gknd 2284 10 an an DT cord-010119-t1x9gknd 2284 11 in in IN cord-010119-t1x9gknd 2284 12 house house NNP cord-010119-t1x9gknd 2284 13 blood blood NN cord-010119-t1x9gknd 2284 14 bank bank NN cord-010119-t1x9gknd 2284 15 and and CC cord-010119-t1x9gknd 2284 16 PBMCs pbmc NNS cord-010119-t1x9gknd 2284 17 were be VBD cord-010119-t1x9gknd 2284 18 separated separate VBN cord-010119-t1x9gknd 2284 19 by by IN cord-010119-t1x9gknd 2284 20 centrifugation centrifugation NN cord-010119-t1x9gknd 2284 21 over over IN cord-010119-t1x9gknd 2284 22 Ficoll Ficoll NNP cord-010119-t1x9gknd 2284 23 - - HYPH cord-010119-t1x9gknd 2284 24 Paque Paque NNP cord-010119-t1x9gknd 2284 25 in in IN cord-010119-t1x9gknd 2284 26 Leuco Leuco NNP cord-010119-t1x9gknd 2284 27 - - HYPH cord-010119-t1x9gknd 2284 28 Sep Sep NNP cord-010119-t1x9gknd 2284 29 tubes tube NNS cord-010119-t1x9gknd 2284 30 as as IN cord-010119-t1x9gknd 2284 31 specified specify VBN cord-010119-t1x9gknd 2284 32 by by IN cord-010119-t1x9gknd 2284 33 the the DT cord-010119-t1x9gknd 2284 34 manufacturer manufacturer NN cord-010119-t1x9gknd 2284 35 . . . cord-010119-t1x9gknd 2285 1 The the DT cord-010119-t1x9gknd 2285 2 pooled pool VBN cord-010119-t1x9gknd 2285 3 donor donor NN cord-010119-t1x9gknd 2285 4 PBMCs pbmc NNS cord-010119-t1x9gknd 2285 5 were be VBD cord-010119-t1x9gknd 2285 6 stored store VBN cord-010119-t1x9gknd 2285 7 at at IN cord-010119-t1x9gknd 2285 8 -80 -80 NNP cord-010119-t1x9gknd 2285 9 . . . cord-010119-t1x9gknd 2286 1 MSCs msc NNS cord-010119-t1x9gknd 2286 2 derived derive VBN cord-010119-t1x9gknd 2286 3 from from IN cord-010119-t1x9gknd 2286 4 bone bone NN cord-010119-t1x9gknd 2286 5 marrow marrow NN cord-010119-t1x9gknd 2286 6 , , , cord-010119-t1x9gknd 2286 7 adipose adipose JJ cord-010119-t1x9gknd 2286 8 tissue tissue NN cord-010119-t1x9gknd 2286 9 or or CC cord-010119-t1x9gknd 2286 10 umbilical umbilical JJ cord-010119-t1x9gknd 2286 11 cord cord NN cord-010119-t1x9gknd 2286 12 ( ( -LRB- cord-010119-t1x9gknd 2286 13 BM BM NNP cord-010119-t1x9gknd 2286 14 - - HYPH cord-010119-t1x9gknd 2286 15 MSC MSC NNP cord-010119-t1x9gknd 2286 16 , , , cord-010119-t1x9gknd 2286 17 Ad Ad NNP cord-010119-t1x9gknd 2286 18 - - HYPH cord-010119-t1x9gknd 2286 19 MSC MSC NNP cord-010119-t1x9gknd 2286 20 , , , cord-010119-t1x9gknd 2286 21 UC UC NNP cord-010119-t1x9gknd 2286 22 - - HYPH cord-010119-t1x9gknd 2286 23 MSC MSC NNP cord-010119-t1x9gknd 2286 24 , , , cord-010119-t1x9gknd 2286 25 respectively respectively RB cord-010119-t1x9gknd 2286 26 ) ) -RRB- cord-010119-t1x9gknd 2286 27 or or CC cord-010119-t1x9gknd 2286 28 human human JJ cord-010119-t1x9gknd 2286 29 umbilical umbilical JJ cord-010119-t1x9gknd 2286 30 cord cord NN cord-010119-t1x9gknd 2286 31 endothelial endothelial NN cord-010119-t1x9gknd 2286 32 cells cell NNS cord-010119-t1x9gknd 2286 33 ( ( -LRB- cord-010119-t1x9gknd 2286 34 HUVEC HUVEC NNP cord-010119-t1x9gknd 2286 35 ) ) -RRB- cord-010119-t1x9gknd 2286 36 were be VBD cord-010119-t1x9gknd 2286 37 serially serially RB cord-010119-t1x9gknd 2286 38 diluted dilute VBN cord-010119-t1x9gknd 2286 39 starting starting NN cord-010119-t1x9gknd 2286 40 at at IN cord-010119-t1x9gknd 2287 1 50 50 CD cord-010119-t1x9gknd 2287 2 - - SYM cord-010119-t1x9gknd 2287 3 60,000 60,000 CD cord-010119-t1x9gknd 2287 4 cells/ cells/ CD cord-010119-t1x9gknd 2287 5 well well UH cord-010119-t1x9gknd 2287 6 and and CC cord-010119-t1x9gknd 2287 7 cultured culture VBN cord-010119-t1x9gknd 2287 8 in in IN cord-010119-t1x9gknd 2287 9 96 96 CD cord-010119-t1x9gknd 2287 10 well well NN cord-010119-t1x9gknd 2287 11 plates plate NNS cord-010119-t1x9gknd 2287 12 for for IN cord-010119-t1x9gknd 2287 13 4 4 CD cord-010119-t1x9gknd 2287 14 - - SYM cord-010119-t1x9gknd 2287 15 48 48 CD cord-010119-t1x9gknd 2287 16 h h NN cord-010119-t1x9gknd 2287 17 in in IN cord-010119-t1x9gknd 2287 18 their -PRON- PRP$ cord-010119-t1x9gknd 2287 19 respective respective JJ cord-010119-t1x9gknd 2287 20 medias media NNS cord-010119-t1x9gknd 2287 21 . . . cord-010119-t1x9gknd 2288 1 On on IN cord-010119-t1x9gknd 2288 2 Day day NN cord-010119-t1x9gknd 2288 3 0 0 CD cord-010119-t1x9gknd 2288 4 , , , cord-010119-t1x9gknd 2288 5 MSCs msc NNS cord-010119-t1x9gknd 2288 6 were be VBD cord-010119-t1x9gknd 2288 7 washed wash VBN cord-010119-t1x9gknd 2288 8 , , , cord-010119-t1x9gknd 2288 9 resuspended resuspend VBN cord-010119-t1x9gknd 2288 10 in in IN cord-010119-t1x9gknd 2288 11 PBMC PBMC NNP cord-010119-t1x9gknd 2288 12 media medium NNS cord-010119-t1x9gknd 2288 13 and and CC cord-010119-t1x9gknd 2288 14 incubated incubate VBN cord-010119-t1x9gknd 2288 15 with with IN cord-010119-t1x9gknd 2288 16 or or CC cord-010119-t1x9gknd 2288 17 without without IN cord-010119-t1x9gknd 2288 18 150,000 150,000 CD cord-010119-t1x9gknd 2288 19 freshly freshly RB cord-010119-t1x9gknd 2288 20 thawed thaw VBN cord-010119-t1x9gknd 2288 21 PBMCs/ PBMCs/ NNP cord-010119-t1x9gknd 2289 1 well well UH cord-010119-t1x9gknd 2289 2 , , , cord-010119-t1x9gknd 2289 3 in in IN cord-010119-t1x9gknd 2289 4 the the DT cord-010119-t1x9gknd 2289 5 presence presence NN cord-010119-t1x9gknd 2289 6 or or CC cord-010119-t1x9gknd 2289 7 absence absence NN cord-010119-t1x9gknd 2289 8 of of IN cord-010119-t1x9gknd 2289 9 phytohemagglutinin phytohemagglutinin NNS cord-010119-t1x9gknd 2289 10 A a NN cord-010119-t1x9gknd 2289 11 ( ( -LRB- cord-010119-t1x9gknd 2289 12 PHA PHA NNP cord-010119-t1x9gknd 2289 13 , , , cord-010119-t1x9gknd 2289 14 0 0 CD cord-010119-t1x9gknd 2289 15 - - SYM cord-010119-t1x9gknd 2289 16 5 5 CD cord-010119-t1x9gknd 2289 17 lg lg NNP cord-010119-t1x9gknd 2289 18 / / SYM cord-010119-t1x9gknd 2289 19 ml ml NNP cord-010119-t1x9gknd 2289 20 ) ) -RRB- cord-010119-t1x9gknd 2289 21 . . . cord-010119-t1x9gknd 2290 1 Proliferation proliferation NN cord-010119-t1x9gknd 2290 2 of of IN cord-010119-t1x9gknd 2290 3 both both DT cord-010119-t1x9gknd 2290 4 MSCs msc NNS cord-010119-t1x9gknd 2290 5 and and CC cord-010119-t1x9gknd 2290 6 PBMCs pbmc NNS cord-010119-t1x9gknd 2290 7 was be VBD cord-010119-t1x9gknd 2290 8 assessed assess VBN cord-010119-t1x9gknd 2290 9 in in IN cord-010119-t1x9gknd 2290 10 triplicate triplicate JJ cord-010119-t1x9gknd 2290 11 wells well NNS cord-010119-t1x9gknd 2290 12 by by IN cord-010119-t1x9gknd 2290 13 quantitation quantitation NN cord-010119-t1x9gknd 2290 14 of of IN cord-010119-t1x9gknd 2290 15 ATP ATP NNP cord-010119-t1x9gknd 2290 16 levels level NNS cord-010119-t1x9gknd 2290 17 using use VBG cord-010119-t1x9gknd 2290 18 the the DT cord-010119-t1x9gknd 2290 19 bioluminescent bioluminescent NN cord-010119-t1x9gknd 2290 20 reagent reagent NN cord-010119-t1x9gknd 2290 21 Cell Cell NNP cord-010119-t1x9gknd 2290 22 Titer Titer NNP cord-010119-t1x9gknd 2290 23 - - HYPH cord-010119-t1x9gknd 2290 24 Glo Glo NNP cord-010119-t1x9gknd 2290 25 ( ( -LRB- cord-010119-t1x9gknd 2290 26 Promega Promega NNP cord-010119-t1x9gknd 2290 27 ) ) -RRB- cord-010119-t1x9gknd 2290 28 . . . cord-010119-t1x9gknd 2291 1 Results result NNS cord-010119-t1x9gknd 2291 2 / / SYM cord-010119-t1x9gknd 2291 3 Finding finding NN cord-010119-t1x9gknd 2291 4 : : : cord-010119-t1x9gknd 2292 1 PBMC PBMC NNS cord-010119-t1x9gknd 2292 2 proliferation proliferation NN cord-010119-t1x9gknd 2292 3 in in IN cord-010119-t1x9gknd 2292 4 response response NN cord-010119-t1x9gknd 2292 5 to to IN cord-010119-t1x9gknd 2292 6 PHA PHA NNP cord-010119-t1x9gknd 2292 7 gave give VBD cord-010119-t1x9gknd 2292 8 a a DT cord-010119-t1x9gknd 2292 9 robust robust JJ cord-010119-t1x9gknd 2292 10 ATP ATP NNP cord-010119-t1x9gknd 2292 11 signal signal NN cord-010119-t1x9gknd 2292 12 by by IN cord-010119-t1x9gknd 2292 13 72 72 CD cord-010119-t1x9gknd 2292 14 h h NN cord-010119-t1x9gknd 2292 15 , , , cord-010119-t1x9gknd 2292 16 with with IN cord-010119-t1x9gknd 2292 17 > > XX cord-010119-t1x9gknd 2292 18 6 6 CD cord-010119-t1x9gknd 2292 19 fold fold VB cord-010119-t1x9gknd 2292 20 increase increase NN cord-010119-t1x9gknd 2292 21 over over IN cord-010119-t1x9gknd 2292 22 control control NN cord-010119-t1x9gknd 2292 23 PBMCs pbmc NNS cord-010119-t1x9gknd 2292 24 . . . cord-010119-t1x9gknd 2293 1 No no DT cord-010119-t1x9gknd 2293 2 increase increase NN cord-010119-t1x9gknd 2293 3 in in IN cord-010119-t1x9gknd 2293 4 ATP ATP NNP cord-010119-t1x9gknd 2293 5 response response NN cord-010119-t1x9gknd 2293 6 or or CC cord-010119-t1x9gknd 2293 7 proliferation proliferation NN cord-010119-t1x9gknd 2293 8 was be VBD cord-010119-t1x9gknd 2293 9 seen see VBN cord-010119-t1x9gknd 2293 10 in in IN cord-010119-t1x9gknd 2293 11 the the DT cord-010119-t1x9gknd 2293 12 absence absence NN cord-010119-t1x9gknd 2293 13 of of IN cord-010119-t1x9gknd 2293 14 PHA PHA NNP cord-010119-t1x9gknd 2293 15 . . . cord-010119-t1x9gknd 2294 1 Co co NN cord-010119-t1x9gknd 2294 2 - - NN cord-010119-t1x9gknd 2294 3 culture culture NN cord-010119-t1x9gknd 2294 4 with with IN cord-010119-t1x9gknd 2294 5 MSCs msc NNS cord-010119-t1x9gknd 2294 6 inhibited inhibit VBN cord-010119-t1x9gknd 2294 7 PBMC PBMC NNP cord-010119-t1x9gknd 2294 8 proliferation proliferation NN cord-010119-t1x9gknd 2294 9 dependent dependent JJ cord-010119-t1x9gknd 2294 10 upon upon IN cord-010119-t1x9gknd 2294 11 MSC MSC NNP cord-010119-t1x9gknd 2294 12 passage passage NN cord-010119-t1x9gknd 2294 13 , , , cord-010119-t1x9gknd 2294 14 source source NN cord-010119-t1x9gknd 2294 15 , , , cord-010119-t1x9gknd 2294 16 MSC MSC NNP cord-010119-t1x9gknd 2294 17 media medium NNS cord-010119-t1x9gknd 2294 18 additive additive NN cord-010119-t1x9gknd 2294 19 . . . cord-010119-t1x9gknd 2295 1 Intra intra JJ cord-010119-t1x9gknd 2295 2 - - JJ cord-010119-t1x9gknd 2295 3 assay assay JJ cord-010119-t1x9gknd 2295 4 variance variance NN cord-010119-t1x9gknd 2295 5 of of IN cord-010119-t1x9gknd 2295 6 triplicate triplicate JJ cord-010119-t1x9gknd 2295 7 samples sample NNS cord-010119-t1x9gknd 2295 8 was be VBD cord-010119-t1x9gknd 2295 9 10.0 10.0 CD cord-010119-t1x9gknd 2295 10 % % NN cord-010119-t1x9gknd 2295 11 . . . cord-010119-t1x9gknd 2296 1 Inter inter JJ cord-010119-t1x9gknd 2296 2 - - JJ cord-010119-t1x9gknd 2296 3 assay assay JJ cord-010119-t1x9gknd 2296 4 variation variation NN cord-010119-t1x9gknd 2296 5 of of IN cord-010119-t1x9gknd 2296 6 MSC MSC NNP cord-010119-t1x9gknd 2296 7 preps prep NNS cord-010119-t1x9gknd 2296 8 run run VBN cord-010119-t1x9gknd 2296 9 under under IN cord-010119-t1x9gknd 2296 10 identical identical JJ cord-010119-t1x9gknd 2296 11 conditions condition NNS cord-010119-t1x9gknd 2296 12 was be VBD cord-010119-t1x9gknd 2296 13 7.5 7.5 CD cord-010119-t1x9gknd 2296 14 % % NN cord-010119-t1x9gknd 2296 15 . . . cord-010119-t1x9gknd 2297 1 Inhibition inhibition NN cord-010119-t1x9gknd 2297 2 of of IN cord-010119-t1x9gknd 2297 3 PBMC PBMC NNP cord-010119-t1x9gknd 2297 4 proliferation proliferation NN cord-010119-t1x9gknd 2297 5 was be VBD cord-010119-t1x9gknd 2297 6 graded grade VBN cord-010119-t1x9gknd 2297 7 from from IN cord-010119-t1x9gknd 2297 8 0 0 CD cord-010119-t1x9gknd 2297 9 - - SYM cord-010119-t1x9gknd 2297 10 100 100 CD cord-010119-t1x9gknd 2297 11 % % NN cord-010119-t1x9gknd 2297 12 over over IN cord-010119-t1x9gknd 2297 13 the the DT cord-010119-t1x9gknd 2297 14 range range NN cord-010119-t1x9gknd 2297 15 MSC MSC NNP cord-010119-t1x9gknd 2297 16 concentrations concentration NNS cord-010119-t1x9gknd 2297 17 therefore therefore RB cord-010119-t1x9gknd 2297 18 an an DT cord-010119-t1x9gknd 2297 19 EC50 EC50 NNP cord-010119-t1x9gknd 2297 20 of of IN cord-010119-t1x9gknd 2297 21 MSC MSC NNP cord-010119-t1x9gknd 2297 22 cell cell NN cord-010119-t1x9gknd 2297 23 number number NN cord-010119-t1x9gknd 2297 24 resulting result VBG cord-010119-t1x9gknd 2297 25 in in IN cord-010119-t1x9gknd 2297 26 50 50 CD cord-010119-t1x9gknd 2297 27 % % NN cord-010119-t1x9gknd 2297 28 suppression suppression NN cord-010119-t1x9gknd 2297 29 of of IN cord-010119-t1x9gknd 2297 30 PBMC PBMC NNP cord-010119-t1x9gknd 2297 31 could could MD cord-010119-t1x9gknd 2297 32 be be VB cord-010119-t1x9gknd 2297 33 determined determine VBN cord-010119-t1x9gknd 2297 34 for for IN cord-010119-t1x9gknd 2297 35 each each DT cord-010119-t1x9gknd 2297 36 MSC MSC NNP cord-010119-t1x9gknd 2297 37 prep prep NN cord-010119-t1x9gknd 2297 38 . . . cord-010119-t1x9gknd 2298 1 This this DT cord-010119-t1x9gknd 2298 2 EC50 EC50 NNP cord-010119-t1x9gknd 2298 3 however however RB cord-010119-t1x9gknd 2298 4 was be VBD cord-010119-t1x9gknd 2298 5 dependent dependent JJ cord-010119-t1x9gknd 2298 6 upon upon IN cord-010119-t1x9gknd 2298 7 PBMC PBMC NNP cord-010119-t1x9gknd 2298 8 donor donor NN cord-010119-t1x9gknd 2298 9 pool pool NN cord-010119-t1x9gknd 2298 10 . . . cord-010119-t1x9gknd 2299 1 Conclusion conclusion NN cord-010119-t1x9gknd 2299 2 : : : cord-010119-t1x9gknd 2299 3 Direct direct JJ cord-010119-t1x9gknd 2299 4 co co NN cord-010119-t1x9gknd 2299 5 - - NN cord-010119-t1x9gknd 2299 6 culture culture NN cord-010119-t1x9gknd 2299 7 of of IN cord-010119-t1x9gknd 2299 8 live live JJ cord-010119-t1x9gknd 2299 9 MSCs msc NNS cord-010119-t1x9gknd 2299 10 with with IN cord-010119-t1x9gknd 2299 11 freshly freshly RB cord-010119-t1x9gknd 2299 12 thawed thaw VBN cord-010119-t1x9gknd 2299 13 PBMCs pbmc NNS cord-010119-t1x9gknd 2299 14 give give VBP cord-010119-t1x9gknd 2299 15 a a DT cord-010119-t1x9gknd 2299 16 robust robust JJ cord-010119-t1x9gknd 2299 17 determination determination NN cord-010119-t1x9gknd 2299 18 of of IN cord-010119-t1x9gknd 2299 19 immunosuppression immunosuppression NN cord-010119-t1x9gknd 2299 20 by by IN cord-010119-t1x9gknd 2299 21 MSCs msc NNS cord-010119-t1x9gknd 2299 22 . . . cord-010119-t1x9gknd 2300 1 Graded grade VBN cord-010119-t1x9gknd 2300 2 responses response NNS cord-010119-t1x9gknd 2300 3 can can MD cord-010119-t1x9gknd 2300 4 be be VB cord-010119-t1x9gknd 2300 5 determined determine VBN cord-010119-t1x9gknd 2300 6 , , , cord-010119-t1x9gknd 2300 7 allowing allow VBG cord-010119-t1x9gknd 2300 8 comparison comparison NN cord-010119-t1x9gknd 2300 9 of of IN cord-010119-t1x9gknd 2300 10 potency potency NN cord-010119-t1x9gknd 2300 11 between between IN cord-010119-t1x9gknd 2300 12 MSC MSC NNP cord-010119-t1x9gknd 2300 13 preparations preparation NNS cord-010119-t1x9gknd 2300 14 . . . cord-010119-t1x9gknd 2301 1 This this DT cord-010119-t1x9gknd 2301 2 streamlined streamlined JJ cord-010119-t1x9gknd 2301 3 assay assay NN cord-010119-t1x9gknd 2301 4 can can MD cord-010119-t1x9gknd 2301 5 be be VB cord-010119-t1x9gknd 2301 6 performed perform VBN cord-010119-t1x9gknd 2301 7 within within IN cord-010119-t1x9gknd 2301 8 72 72 CD cord-010119-t1x9gknd 2301 9 h h NN cord-010119-t1x9gknd 2301 10 , , , cord-010119-t1x9gknd 2301 11 without without IN cord-010119-t1x9gknd 2301 12 irradiating irradiate VBG cord-010119-t1x9gknd 2301 13 cells cell NNS cord-010119-t1x9gknd 2301 14 and and CC cord-010119-t1x9gknd 2301 15 with with IN cord-010119-t1x9gknd 2301 16 minimal minimal JJ cord-010119-t1x9gknd 2301 17 equipment equipment NN cord-010119-t1x9gknd 2301 18 outlay outlay NN cord-010119-t1x9gknd 2301 19 . . . cord-010119-t1x9gknd 2302 1 Background Background NNP cord-010119-t1x9gknd 2302 2 / / SYM cord-010119-t1x9gknd 2302 3 Case Case NNP cord-010119-t1x9gknd 2302 4 Studies Studies NNPS cord-010119-t1x9gknd 2302 5 : : : cord-010119-t1x9gknd 2303 1 A a DT cord-010119-t1x9gknd 2303 2 high high JJ cord-010119-t1x9gknd 2303 3 prevalence prevalence NN cord-010119-t1x9gknd 2303 4 of of IN cord-010119-t1x9gknd 2303 5 iron iron NN cord-010119-t1x9gknd 2303 6 depletion depletion NN cord-010119-t1x9gknd 2303 7 ( ( -LRB- cord-010119-t1x9gknd 2303 8 ID ID NNP cord-010119-t1x9gknd 2303 9 ) ) -RRB- cord-010119-t1x9gknd 2303 10 in in IN cord-010119-t1x9gknd 2303 11 blood blood NN cord-010119-t1x9gknd 2303 12 donors donor NNS cord-010119-t1x9gknd 2303 13 has have VBZ cord-010119-t1x9gknd 2303 14 been be VBN cord-010119-t1x9gknd 2303 15 documented document VBN cord-010119-t1x9gknd 2303 16 by by IN cord-010119-t1x9gknd 2303 17 recent recent JJ cord-010119-t1x9gknd 2303 18 studies study NNS cord-010119-t1x9gknd 2303 19 , , , cord-010119-t1x9gknd 2303 20 but but CC cord-010119-t1x9gknd 2303 21 none none NN cord-010119-t1x9gknd 2303 22 targeted target VBD cord-010119-t1x9gknd 2303 23 high high JJ cord-010119-t1x9gknd 2303 24 school school NN cord-010119-t1x9gknd 2303 25 aged age VBN cord-010119-t1x9gknd 2303 26 donors donor NNS cord-010119-t1x9gknd 2303 27 , , , cord-010119-t1x9gknd 2303 28 who who WP cord-010119-t1x9gknd 2303 29 consistently consistently RB cord-010119-t1x9gknd 2303 30 contribute contribute VBP cord-010119-t1x9gknd 2303 31 10 10 CD cord-010119-t1x9gknd 2303 32 % % NN cord-010119-t1x9gknd 2303 33 or or CC cord-010119-t1x9gknd 2303 34 more more JJR cord-010119-t1x9gknd 2303 35 of of IN cord-010119-t1x9gknd 2303 36 the the DT cord-010119-t1x9gknd 2303 37 US US NNP cord-010119-t1x9gknd 2303 38 blood blood NN cord-010119-t1x9gknd 2303 39 supply supply NN cord-010119-t1x9gknd 2303 40 . . . cord-010119-t1x9gknd 2304 1 Differences difference NNS cord-010119-t1x9gknd 2304 2 between between IN cord-010119-t1x9gknd 2304 3 donors donor NNS cord-010119-t1x9gknd 2304 4 16 16 CD cord-010119-t1x9gknd 2304 5 - - SYM cord-010119-t1x9gknd 2304 6 18 18 CD cord-010119-t1x9gknd 2304 7 years year NNS cord-010119-t1x9gknd 2304 8 old old JJ cord-010119-t1x9gknd 2304 9 ( ( -LRB- cord-010119-t1x9gknd 2304 10 yo yo UH cord-010119-t1x9gknd 2304 11 ) ) -RRB- cord-010119-t1x9gknd 2304 12 and and CC cord-010119-t1x9gknd 2304 13 adults adult NNS cord-010119-t1x9gknd 2304 14 in in IN cord-010119-t1x9gknd 2304 15 baseline baseline NN cord-010119-t1x9gknd 2304 16 and and CC cord-010119-t1x9gknd 2304 17 donation donation NN cord-010119-t1x9gknd 2304 18 - - HYPH cord-010119-t1x9gknd 2304 19 altered alter VBN cord-010119-t1x9gknd 2304 20 iron iron NN cord-010119-t1x9gknd 2304 21 status status NN cord-010119-t1x9gknd 2304 22 are be VBP cord-010119-t1x9gknd 2304 23 important important JJ cord-010119-t1x9gknd 2304 24 to to TO cord-010119-t1x9gknd 2304 25 understand understand VB cord-010119-t1x9gknd 2304 26 because because IN cord-010119-t1x9gknd 2304 27 teenagers teenager NNS cord-010119-t1x9gknd 2304 28 need need VBP cord-010119-t1x9gknd 2304 29 increased increase VBN cord-010119-t1x9gknd 2304 30 iron iron NN cord-010119-t1x9gknd 2304 31 for for IN cord-010119-t1x9gknd 2304 32 physiological physiological JJ cord-010119-t1x9gknd 2304 33 growth growth NN cord-010119-t1x9gknd 2304 34 and and CC cord-010119-t1x9gknd 2304 35 development development NN cord-010119-t1x9gknd 2304 36 and and CC cord-010119-t1x9gknd 2304 37 may may MD cord-010119-t1x9gknd 2304 38 be be VB cord-010119-t1x9gknd 2304 39 more more RBR cord-010119-t1x9gknd 2304 40 susceptible susceptible JJ cord-010119-t1x9gknd 2304 41 to to IN cord-010119-t1x9gknd 2304 42 harm harm NN cord-010119-t1x9gknd 2304 43 from from IN cord-010119-t1x9gknd 2304 44 iron iron NN cord-010119-t1x9gknd 2304 45 depletion depletion NN cord-010119-t1x9gknd 2304 46 . . . cord-010119-t1x9gknd 2305 1 Study Study NNP cord-010119-t1x9gknd 2305 2 Design Design NNP cord-010119-t1x9gknd 2305 3 / / SYM cord-010119-t1x9gknd 2305 4 Method method NN cord-010119-t1x9gknd 2305 5 : : : cord-010119-t1x9gknd 2305 6 Donors donor NNS cord-010119-t1x9gknd 2305 7 aged age VBN cord-010119-t1x9gknd 2305 8 16 16 CD cord-010119-t1x9gknd 2305 9 - - SYM cord-010119-t1x9gknd 2305 10 49 49 CD cord-010119-t1x9gknd 2305 11 were be VBD cord-010119-t1x9gknd 2305 12 eligible eligible JJ cord-010119-t1x9gknd 2305 13 for for IN cord-010119-t1x9gknd 2305 14 ferritin ferritin NN cord-010119-t1x9gknd 2305 15 testing testing NN cord-010119-t1x9gknd 2305 16 if if IN cord-010119-t1x9gknd 2305 17 they -PRON- PRP cord-010119-t1x9gknd 2305 18 donated donate VBD cord-010119-t1x9gknd 2305 19 at at IN cord-010119-t1x9gknd 2305 20 a a DT cord-010119-t1x9gknd 2305 21 high high JJ cord-010119-t1x9gknd 2305 22 school school NN cord-010119-t1x9gknd 2305 23 ( ( -LRB- cord-010119-t1x9gknd 2305 24 HS HS NNP cord-010119-t1x9gknd 2305 25 ) ) -RRB- cord-010119-t1x9gknd 2305 26 blood blood NN cord-010119-t1x9gknd 2305 27 drive drive NN cord-010119-t1x9gknd 2305 28 at at IN cord-010119-t1x9gknd 2305 29 the the DT cord-010119-t1x9gknd 2305 30 start start NN cord-010119-t1x9gknd 2305 31 of of IN cord-010119-t1x9gknd 2305 32 the the DT cord-010119-t1x9gknd 2305 33 2015/16 2015/16 CD cord-010119-t1x9gknd 2305 34 academic academic JJ cord-010119-t1x9gknd 2305 35 year year NN cord-010119-t1x9gknd 2305 36 at at IN cord-010119-t1x9gknd 2305 37 two two CD cord-010119-t1x9gknd 2305 38 blood blood NN cord-010119-t1x9gknd 2305 39 centers center NNS cord-010119-t1x9gknd 2305 40 . . . cord-010119-t1x9gknd 2306 1 Samples sample NNS cord-010119-t1x9gknd 2306 2 from from IN cord-010119-t1x9gknd 2306 3 return return NN cord-010119-t1x9gknd 2306 4 donations donation NNS cord-010119-t1x9gknd 2306 5 over over IN cord-010119-t1x9gknd 2306 6 the the DT cord-010119-t1x9gknd 2306 7 remainder remainder NN cord-010119-t1x9gknd 2306 8 of of IN cord-010119-t1x9gknd 2306 9 the the DT cord-010119-t1x9gknd 2306 10 school school NN cord-010119-t1x9gknd 2306 11 year year NN cord-010119-t1x9gknd 2306 12 were be VBD cord-010119-t1x9gknd 2306 13 also also RB cord-010119-t1x9gknd 2306 14 tested test VBN cord-010119-t1x9gknd 2306 15 . . . cord-010119-t1x9gknd 2307 1 The the DT cord-010119-t1x9gknd 2307 2 prevalence prevalence NN cord-010119-t1x9gknd 2307 3 of of IN cord-010119-t1x9gknd 2307 4 Absent Absent NNP cord-010119-t1x9gknd 2307 5 Iron Iron NNP cord-010119-t1x9gknd 2307 6 Stores Stores NNPS cord-010119-t1x9gknd 2307 7 ( ( -LRB- cord-010119-t1x9gknd 2307 8 AIS AIS NNP cord-010119-t1x9gknd 2307 9 , , , cord-010119-t1x9gknd 2307 10 ferritin ferritin NN cord-010119-t1x9gknd 2307 11 < < XX cord-010119-t1x9gknd 2307 12 12 12 CD cord-010119-t1x9gknd 2307 13 ng ng NNP cord-010119-t1x9gknd 2307 14 / / SYM cord-010119-t1x9gknd 2307 15 ml ml NN cord-010119-t1x9gknd 2307 16 ) ) -RRB- cord-010119-t1x9gknd 2307 17 and and CC cord-010119-t1x9gknd 2307 18 Low Low NNP cord-010119-t1x9gknd 2307 19 Ferritin ferritin NN cord-010119-t1x9gknd 2307 20 ( ( -LRB- cord-010119-t1x9gknd 2307 21 LF lf NN cord-010119-t1x9gknd 2307 22 , , , cord-010119-t1x9gknd 2307 23 ferritin ferritin NN cord-010119-t1x9gknd 2307 24 < < XX cord-010119-t1x9gknd 2307 25 26 26 CD cord-010119-t1x9gknd 2307 26 ng ng NNP cord-010119-t1x9gknd 2307 27 / / SYM cord-010119-t1x9gknd 2307 28 ml ml NN cord-010119-t1x9gknd 2307 29 ) ) -RRB- cord-010119-t1x9gknd 2307 30 were be VBD cord-010119-t1x9gknd 2307 31 estimated estimate VBN cord-010119-t1x9gknd 2307 32 for for IN cord-010119-t1x9gknd 2307 33 16 16 CD cord-010119-t1x9gknd 2307 34 , , , cord-010119-t1x9gknd 2307 35 17 17 CD cord-010119-t1x9gknd 2307 36 , , , cord-010119-t1x9gknd 2307 37 18 18 CD cord-010119-t1x9gknd 2307 38 and and CC cord-010119-t1x9gknd 2307 39 19 19 CD cord-010119-t1x9gknd 2307 40 - - HYPH cord-010119-t1x9gknd 2307 41 49yo 49yo NN cord-010119-t1x9gknd 2307 42 groups group NNS cord-010119-t1x9gknd 2307 43 separately separately RB cord-010119-t1x9gknd 2307 44 for for IN cord-010119-t1x9gknd 2307 45 both both DT cord-010119-t1x9gknd 2307 46 genders gender NNS cord-010119-t1x9gknd 2307 47 . . . cord-010119-t1x9gknd 2308 1 Linkage linkage NN cord-010119-t1x9gknd 2308 2 to to IN cord-010119-t1x9gknd 2308 3 operational operational JJ cord-010119-t1x9gknd 2308 4 databases database NNS cord-010119-t1x9gknd 2308 5 established establish VBN cord-010119-t1x9gknd 2308 6 first first JJ cord-010119-t1x9gknd 2308 7 - - HYPH cord-010119-t1x9gknd 2308 8 time time NN cord-010119-t1x9gknd 2308 9 ( ( -LRB- cord-010119-t1x9gknd 2308 10 FT FT NNP cord-010119-t1x9gknd 2308 11 ) ) -RRB- cord-010119-t1x9gknd 2308 12 vs vs IN cord-010119-t1x9gknd 2308 13 repeat repeat NN cord-010119-t1x9gknd 2308 14 ( ( -LRB- cord-010119-t1x9gknd 2308 15 RPT RPT NNP cord-010119-t1x9gknd 2308 16 ) ) -RRB- cord-010119-t1x9gknd 2308 17 donor donor NN cord-010119-t1x9gknd 2308 18 status status NN cord-010119-t1x9gknd 2308 19 . . . cord-010119-t1x9gknd 2309 1 Linear linear JJ cord-010119-t1x9gknd 2309 2 regression regression NN cord-010119-t1x9gknd 2309 3 analysis analysis NN cord-010119-t1x9gknd 2309 4 tested test VBN cord-010119-t1x9gknd 2309 5 for for IN cord-010119-t1x9gknd 2309 6 differences difference NNS cord-010119-t1x9gknd 2309 7 in in IN cord-010119-t1x9gknd 2309 8 natural natural JJ cord-010119-t1x9gknd 2309 9 log log NN cord-010119-t1x9gknd 2309 10 of of IN cord-010119-t1x9gknd 2309 11 enrollment enrollment NN cord-010119-t1x9gknd 2309 12 ferritin ferritin NN cord-010119-t1x9gknd 2309 13 values value NNS cord-010119-t1x9gknd 2309 14 by by IN cord-010119-t1x9gknd 2309 15 age age NN cord-010119-t1x9gknd 2309 16 . . . cord-010119-t1x9gknd 2310 1 Multiple multiple JJ cord-010119-t1x9gknd 2310 2 logistic logistic JJ cord-010119-t1x9gknd 2310 3 regression regression NN cord-010119-t1x9gknd 2310 4 assessed assess VBN cord-010119-t1x9gknd 2310 5 whether whether IN cord-010119-t1x9gknd 2310 6 young young JJ cord-010119-t1x9gknd 2310 7 age age NN cord-010119-t1x9gknd 2310 8 independently independently RB cord-010119-t1x9gknd 2310 9 predicts predict VBZ cord-010119-t1x9gknd 2310 10 iron iron NN cord-010119-t1x9gknd 2310 11 depletion depletion NN cord-010119-t1x9gknd 2310 12 controlling control VBG cord-010119-t1x9gknd 2310 13 for for IN cord-010119-t1x9gknd 2310 14 donation donation NN cord-010119-t1x9gknd 2310 15 frequency frequency NN cord-010119-t1x9gknd 2310 16 and and CC cord-010119-t1x9gknd 2310 17 other other JJ cord-010119-t1x9gknd 2310 18 factors factor NNS cord-010119-t1x9gknd 2310 19 . . . cord-010119-t1x9gknd 2311 1 Results result NNS cord-010119-t1x9gknd 2311 2 / / SYM cord-010119-t1x9gknd 2311 3 Finding finding NN cord-010119-t1x9gknd 2311 4 : : : cord-010119-t1x9gknd 2311 5 A a DT cord-010119-t1x9gknd 2311 6 total total NN cord-010119-t1x9gknd 2311 7 of of IN cord-010119-t1x9gknd 2311 8 4265 4265 CD cord-010119-t1x9gknd 2311 9 donors donor NNS cord-010119-t1x9gknd 2311 10 contributed contribute VBD cord-010119-t1x9gknd 2311 11 6219 6219 CD cord-010119-t1x9gknd 2311 12 donations donation NNS cord-010119-t1x9gknd 2311 13 . . . cord-010119-t1x9gknd 2312 1 Donors donor NNS cord-010119-t1x9gknd 2312 2 were be VBD cord-010119-t1x9gknd 2312 3 evenly evenly RB cord-010119-t1x9gknd 2312 4 split split VBN cord-010119-t1x9gknd 2312 5 by by IN cord-010119-t1x9gknd 2312 6 gender gender NN cord-010119-t1x9gknd 2312 7 , , , cord-010119-t1x9gknd 2312 8 66 66 CD cord-010119-t1x9gknd 2312 9 % % NN cord-010119-t1x9gknd 2312 10 were be VBD cord-010119-t1x9gknd 2312 11 FT FT NNP cord-010119-t1x9gknd 2312 12 donors donor NNS cord-010119-t1x9gknd 2312 13 , , , cord-010119-t1x9gknd 2312 14 and and CC cord-010119-t1x9gknd 2312 15 87 87 CD cord-010119-t1x9gknd 2312 16 % % NN cord-010119-t1x9gknd 2312 17 were be VBD cord-010119-t1x9gknd 2312 18 16 16 CD cord-010119-t1x9gknd 2312 19 - - HYPH cord-010119-t1x9gknd 2312 20 18yo 18yo JJ cord-010119-t1x9gknd 2312 21 . . . cord-010119-t1x9gknd 2313 1 FT FT NNP cord-010119-t1x9gknd 2313 2 and and CC cord-010119-t1x9gknd 2313 3 RPT RPT NNP cord-010119-t1x9gknd 2313 4 16 16 CD cord-010119-t1x9gknd 2313 5 - - HYPH cord-010119-t1x9gknd 2313 6 18yo 18yo JJ cord-010119-t1x9gknd 2313 7 donors donor NNS cord-010119-t1x9gknd 2313 8 had have VBD cord-010119-t1x9gknd 2313 9 on on IN cord-010119-t1x9gknd 2313 10 average average JJ cord-010119-t1x9gknd 2313 11 lower low JJR cord-010119-t1x9gknd 2313 12 ferritin ferritin NN cord-010119-t1x9gknd 2313 13 values value NNS cord-010119-t1x9gknd 2313 14 at at IN cord-010119-t1x9gknd 2313 15 enrollment enrollment NN cord-010119-t1x9gknd 2313 16 ( ( -LRB- cord-010119-t1x9gknd 2313 17 p<.0001 p<.0001 NNP cord-010119-t1x9gknd 2313 18 ) ) -RRB- cord-010119-t1x9gknd 2313 19 , , , cord-010119-t1x9gknd 2313 20 and and CC cord-010119-t1x9gknd 2313 21 a a DT cord-010119-t1x9gknd 2313 22 greater great JJR cord-010119-t1x9gknd 2313 23 percentage percentage NN cord-010119-t1x9gknd 2313 24 were be VBD cord-010119-t1x9gknd 2313 25 iron iron NN cord-010119-t1x9gknd 2313 26 - - HYPH cord-010119-t1x9gknd 2313 27 depleted deplete VBN cord-010119-t1x9gknd 2313 28 than than IN cord-010119-t1x9gknd 2313 29 donors donor NNS cord-010119-t1x9gknd 2313 30 19 19 CD cord-010119-t1x9gknd 2313 31 - - HYPH cord-010119-t1x9gknd 2313 32 49yo 49yo NN cord-010119-t1x9gknd 2313 33 ( ( -LRB- cord-010119-t1x9gknd 2313 34 Table table NN cord-010119-t1x9gknd 2313 35 ) ) -RRB- cord-010119-t1x9gknd 2313 36 . . . cord-010119-t1x9gknd 2314 1 In in IN cord-010119-t1x9gknd 2314 2 repeated repeat VBN cord-010119-t1x9gknd 2314 3 measures measure NNS cord-010119-t1x9gknd 2314 4 logistic logistic JJ cord-010119-t1x9gknd 2314 5 regression regression NN cord-010119-t1x9gknd 2314 6 analysis analysis NN cord-010119-t1x9gknd 2314 7 using use VBG cord-010119-t1x9gknd 2314 8 data datum NNS cord-010119-t1x9gknd 2314 9 from from IN cord-010119-t1x9gknd 2314 10 all all DT cord-010119-t1x9gknd 2314 11 visits visit NNS cord-010119-t1x9gknd 2314 12 , , , cord-010119-t1x9gknd 2314 13 female female JJ cord-010119-t1x9gknd 2314 14 sex sex NN cord-010119-t1x9gknd 2314 15 , , , cord-010119-t1x9gknd 2314 16 greater great JJR cord-010119-t1x9gknd 2314 17 number number NN cord-010119-t1x9gknd 2314 18 of of IN cord-010119-t1x9gknd 2314 19 previous previous JJ cord-010119-t1x9gknd 2314 20 donations donation NNS cord-010119-t1x9gknd 2314 21 , , , cord-010119-t1x9gknd 2314 22 shorter short JJR cord-010119-t1x9gknd 2314 23 interval interval NN cord-010119-t1x9gknd 2314 24 since since IN cord-010119-t1x9gknd 2314 25 last last JJ cord-010119-t1x9gknd 2314 26 donation donation NN cord-010119-t1x9gknd 2314 27 , , , cord-010119-t1x9gknd 2314 28 and and CC cord-010119-t1x9gknd 2314 29 lower low JJR cord-010119-t1x9gknd 2314 30 body body NN cord-010119-t1x9gknd 2314 31 weight weight NN cord-010119-t1x9gknd 2314 32 were be VBD cord-010119-t1x9gknd 2314 33 risk risk NN cord-010119-t1x9gknd 2314 34 factors factor NNS cord-010119-t1x9gknd 2314 35 for for IN cord-010119-t1x9gknd 2314 36 both both CC cord-010119-t1x9gknd 2314 37 AIS AIS NNP cord-010119-t1x9gknd 2314 38 and and CC cord-010119-t1x9gknd 2314 39 LF LF NNP cord-010119-t1x9gknd 2314 40 . . . cord-010119-t1x9gknd 2315 1 Controlling control VBG cord-010119-t1x9gknd 2315 2 for for IN cord-010119-t1x9gknd 2315 3 these these DT cord-010119-t1x9gknd 2315 4 covariates covariate NNS cord-010119-t1x9gknd 2315 5 , , , cord-010119-t1x9gknd 2315 6 donors donor NNS cord-010119-t1x9gknd 2315 7 aged age VBN cord-010119-t1x9gknd 2315 8 16 16 CD cord-010119-t1x9gknd 2315 9 - - SYM cord-010119-t1x9gknd 2315 10 18 18 CD cord-010119-t1x9gknd 2315 11 have have VBP cord-010119-t1x9gknd 2315 12 sharply sharply RB cord-010119-t1x9gknd 2315 13 higher high JJR cord-010119-t1x9gknd 2315 14 risk risk NN cord-010119-t1x9gknd 2315 15 for for IN cord-010119-t1x9gknd 2315 16 iron iron NN cord-010119-t1x9gknd 2315 17 depletion depletion NN cord-010119-t1x9gknd 2315 18 than than IN cord-010119-t1x9gknd 2315 19 donors donor NNS cord-010119-t1x9gknd 2315 20 19 19 CD cord-010119-t1x9gknd 2315 21 - - HYPH cord-010119-t1x9gknd 2315 22 49yo 49yo NN cord-010119-t1x9gknd 2315 23 . . . cord-010119-t1x9gknd 2316 1 Odds odd NNS cord-010119-t1x9gknd 2316 2 for for IN cord-010119-t1x9gknd 2316 3 LF LF NNP cord-010119-t1x9gknd 2316 4 were be VBD cord-010119-t1x9gknd 2316 5 4 4 CD cord-010119-t1x9gknd 2316 6 to to TO cord-010119-t1x9gknd 2316 7 6 6 CD cord-010119-t1x9gknd 2316 8 times time NNS cord-010119-t1x9gknd 2316 9 greater great JJR cord-010119-t1x9gknd 2316 10 in in IN cord-010119-t1x9gknd 2316 11 the the DT cord-010119-t1x9gknd 2316 12 younger young JJR cord-010119-t1x9gknd 2316 13 donors donor NNS cord-010119-t1x9gknd 2316 14 , , , cord-010119-t1x9gknd 2316 15 and and CC cord-010119-t1x9gknd 2316 16 for for IN cord-010119-t1x9gknd 2316 17 AIS AIS NNP cord-010119-t1x9gknd 2316 18 were be VBD cord-010119-t1x9gknd 2316 19 3-to 3-to CD cord-010119-t1x9gknd 2316 20 4fold 4fold CD cord-010119-t1x9gknd 2316 21 higher high JJR cord-010119-t1x9gknd 2316 22 . . . cord-010119-t1x9gknd 2317 1 Preliminary preliminary JJ cord-010119-t1x9gknd 2317 2 statistical statistical JJ cord-010119-t1x9gknd 2317 3 models model NNS cord-010119-t1x9gknd 2317 4 indicate indicate VBP cord-010119-t1x9gknd 2317 5 16yo 16yo JJ cord-010119-t1x9gknd 2317 6 donors donor NNS cord-010119-t1x9gknd 2317 7 may may MD cord-010119-t1x9gknd 2317 8 have have VB cord-010119-t1x9gknd 2317 9 greater great JJR cord-010119-t1x9gknd 2317 10 risk risk NN cord-010119-t1x9gknd 2317 11 for for IN cord-010119-t1x9gknd 2317 12 LF LF NNP cord-010119-t1x9gknd 2317 13 than than IN cord-010119-t1x9gknd 2317 14 17 17 CD cord-010119-t1x9gknd 2317 15 or or CC cord-010119-t1x9gknd 2317 16 18yo 18yo JJ cord-010119-t1x9gknd 2317 17 by by IN cord-010119-t1x9gknd 2317 18 4 4 CD cord-010119-t1x9gknd 2317 19 to to TO cord-010119-t1x9gknd 2317 20 5 5 CD cord-010119-t1x9gknd 2317 21 percentage percentage NN cord-010119-t1x9gknd 2317 22 points point NNS cord-010119-t1x9gknd 2317 23 , , , cord-010119-t1x9gknd 2317 24 controlling control VBG cord-010119-t1x9gknd 2317 25 for for IN cord-010119-t1x9gknd 2317 26 other other JJ cord-010119-t1x9gknd 2317 27 factors factor NNS cord-010119-t1x9gknd 2317 28 ( ( -LRB- cord-010119-t1x9gknd 2317 29 p5.06 p5.06 NNS cord-010119-t1x9gknd 2317 30 ) ) -RRB- cord-010119-t1x9gknd 2317 31 . . . cord-010119-t1x9gknd 2318 1 Conclusion conclusion NN cord-010119-t1x9gknd 2318 2 : : : cord-010119-t1x9gknd 2319 1 The the DT cord-010119-t1x9gknd 2319 2 prevalence prevalence NN cord-010119-t1x9gknd 2319 3 of of IN cord-010119-t1x9gknd 2319 4 iron iron NN cord-010119-t1x9gknd 2319 5 depletion depletion NN cord-010119-t1x9gknd 2319 6 varies vary VBZ cord-010119-t1x9gknd 2319 7 markedly markedly RB cord-010119-t1x9gknd 2319 8 by by IN cord-010119-t1x9gknd 2319 9 age age NN cord-010119-t1x9gknd 2319 10 , , , cord-010119-t1x9gknd 2319 11 sex sex NN cord-010119-t1x9gknd 2319 12 , , , cord-010119-t1x9gknd 2319 13 and and CC cord-010119-t1x9gknd 2319 14 donation donation NN cord-010119-t1x9gknd 2319 15 frequency frequency NN cord-010119-t1x9gknd 2319 16 , , , cord-010119-t1x9gknd 2319 17 but but CC cord-010119-t1x9gknd 2319 18 was be VBD cord-010119-t1x9gknd 2319 19 considerably considerably RB cord-010119-t1x9gknd 2319 20 higher high JJR cord-010119-t1x9gknd 2319 21 in in IN cord-010119-t1x9gknd 2319 22 16 16 CD cord-010119-t1x9gknd 2319 23 - - HYPH cord-010119-t1x9gknd 2319 24 18yo 18yo JJ cord-010119-t1x9gknd 2319 25 donors donor NNS cord-010119-t1x9gknd 2319 26 than than IN cord-010119-t1x9gknd 2319 27 in in IN cord-010119-t1x9gknd 2319 28 adult adult NN cord-010119-t1x9gknd 2319 29 controls control NNS cord-010119-t1x9gknd 2319 30 . . . cord-010119-t1x9gknd 2320 1 Logistic logistic JJ cord-010119-t1x9gknd 2320 2 regression regression NN cord-010119-t1x9gknd 2320 3 analysis analysis NN cord-010119-t1x9gknd 2320 4 confirms confirm VBZ cord-010119-t1x9gknd 2320 5 lower low JJR cord-010119-t1x9gknd 2320 6 age age NN cord-010119-t1x9gknd 2320 7 as as IN cord-010119-t1x9gknd 2320 8 an an DT cord-010119-t1x9gknd 2320 9 independent independent JJ cord-010119-t1x9gknd 2320 10 risk risk NN cord-010119-t1x9gknd 2320 11 factor factor NN cord-010119-t1x9gknd 2320 12 for for IN cord-010119-t1x9gknd 2320 13 iron iron NN cord-010119-t1x9gknd 2320 14 depletion depletion NN cord-010119-t1x9gknd 2320 15 . . . cord-010119-t1x9gknd 2321 1 Blood blood NN cord-010119-t1x9gknd 2321 2 centers center NNS cord-010119-t1x9gknd 2321 3 should should MD cord-010119-t1x9gknd 2321 4 implement implement VB cord-010119-t1x9gknd 2321 5 measures measure NNS cord-010119-t1x9gknd 2321 6 to to TO cord-010119-t1x9gknd 2321 7 mitigate mitigate VB cord-010119-t1x9gknd 2321 8 higher high JJR cord-010119-t1x9gknd 2321 9 risk risk NN cord-010119-t1x9gknd 2321 10 for for IN cord-010119-t1x9gknd 2321 11 iron iron NN cord-010119-t1x9gknd 2321 12 depletion depletion NN cord-010119-t1x9gknd 2321 13 and and CC cord-010119-t1x9gknd 2321 14 the the DT cord-010119-t1x9gknd 2321 15 potential potential JJ cord-010119-t1x9gknd 2321 16 adverse adverse JJ cord-010119-t1x9gknd 2321 17 consequences consequence NNS cord-010119-t1x9gknd 2321 18 for for IN cord-010119-t1x9gknd 2321 19 this this DT cord-010119-t1x9gknd 2321 20 population population NN cord-010119-t1x9gknd 2321 21 of of IN cord-010119-t1x9gknd 2321 22 vulnerable vulnerable JJ cord-010119-t1x9gknd 2321 23 donors donor NNS cord-010119-t1x9gknd 2321 24 . . . cord-010119-t1x9gknd 2322 1 Mitigation mitigation NN cord-010119-t1x9gknd 2322 2 of of IN cord-010119-t1x9gknd 2322 3 Iron Iron NNP cord-010119-t1x9gknd 2322 4 Deficiency Deficiency NNP cord-010119-t1x9gknd 2322 5 in in IN cord-010119-t1x9gknd 2322 6 Young Young NNP cord-010119-t1x9gknd 2322 7 Donors Donors NNPS cord-010119-t1x9gknd 2322 8 -a -a . cord-010119-t1x9gknd 2323 1 Preliminary Preliminary NNP cord-010119-t1x9gknd 2323 2 Report Report NNP cord-010119-t1x9gknd 2323 3 Ralph Ralph NNP cord-010119-t1x9gknd 2323 4 R R NNP cord-010119-t1x9gknd 2323 5 Vassallo Vassallo NNP cord-010119-t1x9gknd 2323 6 * * NFP cord-010119-t1x9gknd 2323 7 , , , cord-010119-t1x9gknd 2323 8 Marjorie Marjorie NNP cord-010119-t1x9gknd 2323 9 D D NNP cord-010119-t1x9gknd 2323 10 Bravo Bravo NNP cord-010119-t1x9gknd 2323 11 , , , cord-010119-t1x9gknd 2323 12 Mary Mary NNP cord-010119-t1x9gknd 2323 13 Townsend Townsend NNP cord-010119-t1x9gknd 2323 14 and and CC cord-010119-t1x9gknd 2323 15 Hany Hany NNP cord-010119-t1x9gknd 2323 16 Kamel Kamel NNP cord-010119-t1x9gknd 2323 17 . . . cord-010119-t1x9gknd 2324 1 Blood blood NN cord-010119-t1x9gknd 2324 2 Systems Systems NNPS cord-010119-t1x9gknd 2324 3 , , , cord-010119-t1x9gknd 2325 1 Inc. Inc. NNP cord-010119-t1x9gknd 2325 2 Background Background NNP cord-010119-t1x9gknd 2325 3 / / SYM cord-010119-t1x9gknd 2325 4 Case Case NNP cord-010119-t1x9gknd 2325 5 Studies Studies NNPS cord-010119-t1x9gknd 2326 1 : : : cord-010119-t1x9gknd 2326 2 Iron iron NN cord-010119-t1x9gknd 2326 3 deficiency deficiency NN cord-010119-t1x9gknd 2326 4 is be VBZ cord-010119-t1x9gknd 2326 5 observed observe VBN cord-010119-t1x9gknd 2326 6 in in IN cord-010119-t1x9gknd 2326 7 blood blood NN cord-010119-t1x9gknd 2326 8 donors donor NNS cord-010119-t1x9gknd 2326 9 who who WP cord-010119-t1x9gknd 2326 10 meet meet VBP cord-010119-t1x9gknd 2326 11 regulatory regulatory JJ cord-010119-t1x9gknd 2326 12 hemoglobin hemoglobin NN cord-010119-t1x9gknd 2326 13 ( ( -LRB- cord-010119-t1x9gknd 2326 14 Hb Hb NNP cord-010119-t1x9gknd 2326 15 ) ) -RRB- cord-010119-t1x9gknd 2326 16 requirements requirement NNS cord-010119-t1x9gknd 2326 17 for for IN cord-010119-t1x9gknd 2326 18 blood blood NN cord-010119-t1x9gknd 2326 19 donation donation NN cord-010119-t1x9gknd 2326 20 . . . cord-010119-t1x9gknd 2327 1 Frequent frequent JJ cord-010119-t1x9gknd 2327 2 donations donation NNS cord-010119-t1x9gknd 2327 3 result result VBP cord-010119-t1x9gknd 2327 4 in in IN cord-010119-t1x9gknd 2327 5 negative negative JJ cord-010119-t1x9gknd 2327 6 iron iron NN cord-010119-t1x9gknd 2327 7 balance balance NN cord-010119-t1x9gknd 2327 8 and and CC cord-010119-t1x9gknd 2327 9 eventually eventually RB cord-010119-t1x9gknd 2327 10 lead lead VBP cord-010119-t1x9gknd 2327 11 to to IN cord-010119-t1x9gknd 2327 12 anemia anemia NN cord-010119-t1x9gknd 2327 13 . . . cord-010119-t1x9gknd 2328 1 Young young JJ cord-010119-t1x9gknd 2328 2 donors donor NNS cord-010119-t1x9gknd 2328 3 may may MD cord-010119-t1x9gknd 2328 4 be be VB cord-010119-t1x9gknd 2328 5 at at IN cord-010119-t1x9gknd 2328 6 risk risk NN cord-010119-t1x9gknd 2328 7 for for IN cord-010119-t1x9gknd 2328 8 adverse adverse JJ cord-010119-t1x9gknd 2328 9 health health NN cord-010119-t1x9gknd 2328 10 consequences consequence NNS cord-010119-t1x9gknd 2328 11 ( ( -LRB- cord-010119-t1x9gknd 2328 12 cognitive cognitive JJ cord-010119-t1x9gknd 2328 13 dysfunction dysfunction NN cord-010119-t1x9gknd 2328 14 , , , cord-010119-t1x9gknd 2328 15 pregnancy pregnancy NN cord-010119-t1x9gknd 2328 16 - - HYPH cord-010119-t1x9gknd 2328 17 related relate VBN cord-010119-t1x9gknd 2328 18 complications complication NNS cord-010119-t1x9gknd 2328 19 , , , cord-010119-t1x9gknd 2328 20 fatigue fatigue NN cord-010119-t1x9gknd 2328 21 , , , cord-010119-t1x9gknd 2328 22 decreased decrease VBD cord-010119-t1x9gknd 2328 23 exercise exercise NN cord-010119-t1x9gknd 2328 24 endurance endurance NN cord-010119-t1x9gknd 2328 25 and and CC cord-010119-t1x9gknd 2328 26 pica pica NN cord-010119-t1x9gknd 2328 27 ) ) -RRB- cord-010119-t1x9gknd 2328 28 even even RB cord-010119-t1x9gknd 2328 29 before before IN cord-010119-t1x9gknd 2328 30 anemia anemia NN cord-010119-t1x9gknd 2328 31 occurs occur VBZ cord-010119-t1x9gknd 2328 32 . . . cord-010119-t1x9gknd 2329 1 Study Study NNP cord-010119-t1x9gknd 2329 2 Design Design NNP cord-010119-t1x9gknd 2329 3 / / SYM cord-010119-t1x9gknd 2329 4 Method method NN cord-010119-t1x9gknd 2329 5 : : : cord-010119-t1x9gknd 2330 1 Serum serum NN cord-010119-t1x9gknd 2330 2 ferritin ferritin NN cord-010119-t1x9gknd 2330 3 testing testing NN cord-010119-t1x9gknd 2330 4 was be VBD cord-010119-t1x9gknd 2330 5 implemented implement VBN cord-010119-t1x9gknd 2330 6 on on IN cord-010119-t1x9gknd 2330 7 12/19/ 12/19/ CD cord-010119-t1x9gknd 2330 8 2016 2016 CD cord-010119-t1x9gknd 2330 9 by by IN cord-010119-t1x9gknd 2330 10 a a DT cord-010119-t1x9gknd 2330 11 large large JJ cord-010119-t1x9gknd 2330 12 blood blood NN cord-010119-t1x9gknd 2330 13 collector collector NN cord-010119-t1x9gknd 2330 14 . . . cord-010119-t1x9gknd 2331 1 Testing testing NN cord-010119-t1x9gknd 2331 2 was be VBD cord-010119-t1x9gknd 2331 3 performed perform VBN cord-010119-t1x9gknd 2331 4 on on IN cord-010119-t1x9gknd 2331 5 successful successful JJ cord-010119-t1x9gknd 2331 6 16 16 CD cord-010119-t1x9gknd 2331 7 - - SYM cord-010119-t1x9gknd 2331 8 18 18 CD cord-010119-t1x9gknd 2331 9 y y NN cord-010119-t1x9gknd 2331 10 / / SYM cord-010119-t1x9gknd 2331 11 o o NN cord-010119-t1x9gknd 2331 12 whole whole JJ cord-010119-t1x9gknd 2331 13 blood blood NN cord-010119-t1x9gknd 2331 14 and and CC cord-010119-t1x9gknd 2331 15 apheresis apheresis NN cord-010119-t1x9gknd 2331 16 donations donation NNS cord-010119-t1x9gknd 2331 17 . . . cord-010119-t1x9gknd 2332 1 Low low JJ cord-010119-t1x9gknd 2332 2 ferritin ferritin NN cord-010119-t1x9gknd 2332 3 ( ( -LRB- cord-010119-t1x9gknd 2332 4 LF LF NNP cord-010119-t1x9gknd 2332 5 ) ) -RRB- cord-010119-t1x9gknd 2332 6 was be VBD cord-010119-t1x9gknd 2332 7 defined define VBN cord-010119-t1x9gknd 2332 8 as as IN cord-010119-t1x9gknd 2332 9 a a DT cord-010119-t1x9gknd 2332 10 value value NN cord-010119-t1x9gknd 2332 11 < < XX cord-010119-t1x9gknd 2332 12 20 20 CD cord-010119-t1x9gknd 2332 13 ng ng NN cord-010119-t1x9gknd 2332 14 / / SYM cord-010119-t1x9gknd 2332 15 mL ml NN cord-010119-t1x9gknd 2332 16 in in IN cord-010119-t1x9gknd 2332 17 females female NNS cord-010119-t1x9gknd 2332 18 ( ( -LRB- cord-010119-t1x9gknd 2332 19 F F NNP cord-010119-t1x9gknd 2332 20 ) ) -RRB- cord-010119-t1x9gknd 2332 21 and and CC cord-010119-t1x9gknd 2332 22 < < XX cord-010119-t1x9gknd 2332 23 30 30 CD cord-010119-t1x9gknd 2332 24 ng ng NN cord-010119-t1x9gknd 2332 25 / / SYM cord-010119-t1x9gknd 2332 26 mL ml NN cord-010119-t1x9gknd 2332 27 in in IN cord-010119-t1x9gknd 2332 28 males male NNS cord-010119-t1x9gknd 2332 29 ( ( -LRB- cord-010119-t1x9gknd 2332 30 M M NNP cord-010119-t1x9gknd 2332 31 ) ) -RRB- cord-010119-t1x9gknd 2332 32 . . . cord-010119-t1x9gknd 2333 1 Donors donor NNS cord-010119-t1x9gknd 2333 2 with with IN cord-010119-t1x9gknd 2333 3 low low JJ cord-010119-t1x9gknd 2333 4 ferritin ferritin NNS cord-010119-t1x9gknd 2333 5 were be VBD cord-010119-t1x9gknd 2333 6 notified notify VBN cord-010119-t1x9gknd 2333 7 of of IN cord-010119-t1x9gknd 2333 8 deferral deferral NN cord-010119-t1x9gknd 2333 9 from from IN cord-010119-t1x9gknd 2333 10 red red JJ cord-010119-t1x9gknd 2333 11 blood blood NN cord-010119-t1x9gknd 2333 12 cell cell NN cord-010119-t1x9gknd 2333 13 ( ( -LRB- cord-010119-t1x9gknd 2333 14 RBC RBC NNP cord-010119-t1x9gknd 2333 15 ) ) -RRB- cord-010119-t1x9gknd 2333 16 donations donation NNS cord-010119-t1x9gknd 2333 17 ( ( -LRB- cord-010119-t1x9gknd 2333 18 12 12 CD cord-010119-t1x9gknd 2333 19 months month NNS cord-010119-t1x9gknd 2333 20 for for IN cord-010119-t1x9gknd 2333 21 F F NNP cord-010119-t1x9gknd 2333 22 and and CC cord-010119-t1x9gknd 2333 23 6 6 CD cord-010119-t1x9gknd 2333 24 months month NNS cord-010119-t1x9gknd 2333 25 for for IN cord-010119-t1x9gknd 2333 26 M M NNP cord-010119-t1x9gknd 2333 27 ) ) -RRB- cord-010119-t1x9gknd 2333 28 and and CC cord-010119-t1x9gknd 2333 29 counseled counsel VBD cord-010119-t1x9gknd 2333 30 to to TO cord-010119-t1x9gknd 2333 31 take take VB cord-010119-t1x9gknd 2333 32 18 18 CD cord-010119-t1x9gknd 2333 33 - - SYM cord-010119-t1x9gknd 2333 34 28 28 CD cord-010119-t1x9gknd 2333 35 mg mg NN cord-010119-t1x9gknd 2333 36 of of IN cord-010119-t1x9gknd 2333 37 elemental elemental JJ cord-010119-t1x9gknd 2333 38 iron iron NN cord-010119-t1x9gknd 2333 39 daily daily RB cord-010119-t1x9gknd 2333 40 for for IN cord-010119-t1x9gknd 2333 41 60 60 CD cord-010119-t1x9gknd 2333 42 days day NNS cord-010119-t1x9gknd 2333 43 . . . cord-010119-t1x9gknd 2334 1 For for IN cord-010119-t1x9gknd 2334 2 M M NNP cord-010119-t1x9gknd 2334 3 and and CC cord-010119-t1x9gknd 2334 4 F F NNP cord-010119-t1x9gknd 2334 5 , , , cord-010119-t1x9gknd 2334 6 a a DT cord-010119-t1x9gknd 2334 7 ferritin ferritin NN cord-010119-t1x9gknd 2334 8 < < XX cord-010119-t1x9gknd 2335 1 12 12 CD cord-010119-t1x9gknd 2335 2 ng ng NNP cord-010119-t1x9gknd 2335 3 / / SYM cord-010119-t1x9gknd 2335 4 mL mL NNP cord-010119-t1x9gknd 2335 5 indicated indicate VBD cord-010119-t1x9gknd 2335 6 absent absent JJ cord-010119-t1x9gknd 2335 7 iron iron NN cord-010119-t1x9gknd 2335 8 stores store NNS cord-010119-t1x9gknd 2335 9 ( ( -LRB- cord-010119-t1x9gknd 2335 10 AIS AIS NNP cord-010119-t1x9gknd 2335 11 ) ) -RRB- cord-010119-t1x9gknd 2335 12 and and CC cord-010119-t1x9gknd 2335 13 < < XX cord-010119-t1x9gknd 2335 14 26 26 CD cord-010119-t1x9gknd 2335 15 ng ng NN cord-010119-t1x9gknd 2335 16 / / SYM cord-010119-t1x9gknd 2335 17 mL ml NN cord-010119-t1x9gknd 2336 1 indicated indicate VBD cord-010119-t1x9gknd 2336 2 iron iron NN cord-010119-t1x9gknd 2336 3 deficient deficient JJ cord-010119-t1x9gknd 2336 4 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 2336 5 ( ( -LRB- cord-010119-t1x9gknd 2336 6 IDE IDE NNP cord-010119-t1x9gknd 2336 7 ) ) -RRB- cord-010119-t1x9gknd 2336 8 . . . cord-010119-t1x9gknd 2337 1 Ferritin ferritin NN cord-010119-t1x9gknd 2337 2 levels level NNS cord-010119-t1x9gknd 2337 3 ! ! . cord-010119-t1x9gknd 2338 1 20 20 CD cord-010119-t1x9gknd 2338 2 ng ng NN cord-010119-t1x9gknd 2338 3 / / SYM cord-010119-t1x9gknd 2338 4 mL ml NN cord-010119-t1x9gknd 2338 5 in in IN cord-010119-t1x9gknd 2338 6 F F NNP cord-010119-t1x9gknd 2338 7 and and CC cord-010119-t1x9gknd 2338 8 ! ! . cord-010119-t1x9gknd 2339 1 30 30 CD cord-010119-t1x9gknd 2339 2 ng ng NN cord-010119-t1x9gknd 2339 3 / / SYM cord-010119-t1x9gknd 2339 4 mL ml NN cord-010119-t1x9gknd 2339 5 in in IN cord-010119-t1x9gknd 2339 6 M M NNP cord-010119-t1x9gknd 2339 7 were be VBD cord-010119-t1x9gknd 2339 8 considered consider VBN cord-010119-t1x9gknd 2339 9 as as IN cord-010119-t1x9gknd 2339 10 indicating indicate VBG cord-010119-t1x9gknd 2339 11 an an DT cord-010119-t1x9gknd 2339 12 iron iron NN cord-010119-t1x9gknd 2339 13 - - HYPH cord-010119-t1x9gknd 2339 14 replete replete JJ cord-010119-t1x9gknd 2339 15 state state NN cord-010119-t1x9gknd 2339 16 . . . cord-010119-t1x9gknd 2340 1 Conclusion conclusion NN cord-010119-t1x9gknd 2340 2 : : : cord-010119-t1x9gknd 2341 1 Ferritin ferritin NN cord-010119-t1x9gknd 2341 2 testing testing NN cord-010119-t1x9gknd 2341 3 of of IN cord-010119-t1x9gknd 2341 4 young young JJ cord-010119-t1x9gknd 2341 5 donors donor NNS cord-010119-t1x9gknd 2341 6 identified identify VBD cord-010119-t1x9gknd 2341 7 individuals individual NNS cord-010119-t1x9gknd 2341 8 with with IN cord-010119-t1x9gknd 2341 9 LF lf NN cord-010119-t1x9gknd 2341 10 who who WP cord-010119-t1x9gknd 2341 11 would would MD cord-010119-t1x9gknd 2341 12 benefit benefit VB cord-010119-t1x9gknd 2341 13 from from IN cord-010119-t1x9gknd 2341 14 risk risk NN cord-010119-t1x9gknd 2341 15 mitigation mitigation NN cord-010119-t1x9gknd 2341 16 , , , cord-010119-t1x9gknd 2341 17 e.g. e.g. RB cord-010119-t1x9gknd 2341 18 , , , cord-010119-t1x9gknd 2341 19 delaying delay VBG cord-010119-t1x9gknd 2341 20 subsequent subsequent JJ cord-010119-t1x9gknd 2341 21 RBC RBC NNP cord-010119-t1x9gknd 2341 22 donations donation NNS cord-010119-t1x9gknd 2341 23 and/or and/or CC cord-010119-t1x9gknd 2341 24 taking take VBG cord-010119-t1x9gknd 2341 25 iron iron NN cord-010119-t1x9gknd 2341 26 supplements supplement NNS cord-010119-t1x9gknd 2341 27 . . . cord-010119-t1x9gknd 2342 1 LF LF NNP cord-010119-t1x9gknd 2342 2 is be VBZ cord-010119-t1x9gknd 2342 3 more more RBR cord-010119-t1x9gknd 2342 4 common common JJ cord-010119-t1x9gknd 2342 5 in in IN cord-010119-t1x9gknd 2342 6 F F NNP cord-010119-t1x9gknd 2342 7 than than IN cord-010119-t1x9gknd 2342 8 in in IN cord-010119-t1x9gknd 2342 9 M M NNP cord-010119-t1x9gknd 2342 10 donors donor NNS cord-010119-t1x9gknd 2342 11 . . . cord-010119-t1x9gknd 2343 1 LF LF NNP cord-010119-t1x9gknd 2343 2 is be VBZ cord-010119-t1x9gknd 2343 3 more more RBR cord-010119-t1x9gknd 2343 4 prevalent prevalent JJ cord-010119-t1x9gknd 2343 5 in in IN cord-010119-t1x9gknd 2343 6 M M NNP cord-010119-t1x9gknd 2343 7 and and CC cord-010119-t1x9gknd 2343 8 F F NNP cord-010119-t1x9gknd 2343 9 donors donor NNS cord-010119-t1x9gknd 2343 10 with with IN cord-010119-t1x9gknd 2343 11 any any DT cord-010119-t1x9gknd 2343 12 RBC RBC NNP cord-010119-t1x9gknd 2343 13 donations donation NNS cord-010119-t1x9gknd 2343 14 in in IN cord-010119-t1x9gknd 2343 15 the the DT cord-010119-t1x9gknd 2343 16 prior prior JJ cord-010119-t1x9gknd 2343 17 24 24 CD cord-010119-t1x9gknd 2343 18 months month NNS cord-010119-t1x9gknd 2343 19 . . . cord-010119-t1x9gknd 2344 1 An an DT cord-010119-t1x9gknd 2344 2 appreciable appreciable JJ cord-010119-t1x9gknd 2344 3 number number NN cord-010119-t1x9gknd 2344 4 of of IN cord-010119-t1x9gknd 2344 5 donors donor NNS cord-010119-t1x9gknd 2344 6 with with IN cord-010119-t1x9gknd 2344 7 no no DT cord-010119-t1x9gknd 2344 8 RBC RBC NNP cord-010119-t1x9gknd 2344 9 donations donation NNS cord-010119-t1x9gknd 2344 10 in in IN cord-010119-t1x9gknd 2344 11 the the DT cord-010119-t1x9gknd 2344 12 prior prior JJ cord-010119-t1x9gknd 2344 13 24 24 CD cord-010119-t1x9gknd 2344 14 months month NNS cord-010119-t1x9gknd 2344 15 presented present VBN cord-010119-t1x9gknd 2344 16 with with IN cord-010119-t1x9gknd 2344 17 LF LF NNP cord-010119-t1x9gknd 2344 18 . . . cord-010119-t1x9gknd 2345 1 These these DT cord-010119-t1x9gknd 2345 2 data datum NNS cord-010119-t1x9gknd 2345 3 may may MD cord-010119-t1x9gknd 2345 4 be be VB cord-010119-t1x9gknd 2345 5 useful useful JJ cord-010119-t1x9gknd 2345 6 in in IN cord-010119-t1x9gknd 2345 7 conducting conduct VBG cord-010119-t1x9gknd 2345 8 a a DT cord-010119-t1x9gknd 2345 9 riskbased riskbased JJ cord-010119-t1x9gknd 2345 10 decision decision NN cord-010119-t1x9gknd 2345 11 making make VBG cord-010119-t1x9gknd 2345 12 exercise exercise NN cord-010119-t1x9gknd 2345 13 to to TO cord-010119-t1x9gknd 2345 14 establish establish VB cord-010119-t1x9gknd 2345 15 recommendations recommendation NNS cord-010119-t1x9gknd 2345 16 for for IN cord-010119-t1x9gknd 2345 17 risk risk NN cord-010119-t1x9gknd 2345 18 mitigation mitigation NN cord-010119-t1x9gknd 2345 19 which which WDT cord-010119-t1x9gknd 2345 20 could could MD cord-010119-t1x9gknd 2345 21 be be VB cord-010119-t1x9gknd 2345 22 different different JJ cord-010119-t1x9gknd 2345 23 for for IN cord-010119-t1x9gknd 2345 24 M M NNP cord-010119-t1x9gknd 2345 25 than than IN cord-010119-t1x9gknd 2345 26 for for IN cord-010119-t1x9gknd 2345 27 F F NNP cord-010119-t1x9gknd 2345 28 , , , cord-010119-t1x9gknd 2345 29 e.g. e.g. RB cord-010119-t1x9gknd 2345 30 , , , cord-010119-t1x9gknd 2345 31 universal universal JJ cord-010119-t1x9gknd 2345 32 iron iron NN cord-010119-t1x9gknd 2345 33 replacement replacement NN cord-010119-t1x9gknd 2345 34 in in IN cord-010119-t1x9gknd 2345 35 teen teen JJ cord-010119-t1x9gknd 2345 36 male male JJ cord-010119-t1x9gknd 2345 37 donors donor NNS cord-010119-t1x9gknd 2345 38 may may MD cord-010119-t1x9gknd 2345 39 not not RB cord-010119-t1x9gknd 2345 40 be be VB cord-010119-t1x9gknd 2345 41 warranted warrant VBN cord-010119-t1x9gknd 2345 42 above above IN cord-010119-t1x9gknd 2345 43 a a DT cord-010119-t1x9gknd 2345 44 certain certain JJ cord-010119-t1x9gknd 2345 45 Hb Hb NNP cord-010119-t1x9gknd 2345 46 value value NN cord-010119-t1x9gknd 2345 47 . . . cord-010119-t1x9gknd 2346 1 Ferritin ferritin NN cord-010119-t1x9gknd 2346 2 Blood blood NN cord-010119-t1x9gknd 2346 3 Screening screening NN cord-010119-t1x9gknd 2346 4 in in IN cord-010119-t1x9gknd 2346 5 Minor Minor NNP cord-010119-t1x9gknd 2346 6 or or CC cord-010119-t1x9gknd 2346 7 Young young JJ cord-010119-t1x9gknd 2346 8 Adult Adult NNP cord-010119-t1x9gknd 2346 9 Donors Donors NNP cord-010119-t1x9gknd 2346 10 Jennifer Jennifer NNP cord-010119-t1x9gknd 2346 11 L L NNP cord-010119-t1x9gknd 2346 12 Ritter Ritter NNP cord-010119-t1x9gknd 2346 13 * * NFP cord-010119-t1x9gknd 2346 14 1 1 CD cord-010119-t1x9gknd 2346 15 , , , cord-010119-t1x9gknd 2346 16 Joan Joan NNP cord-010119-t1x9gknd 2346 17 Williams Williams NNP cord-010119-t1x9gknd 2346 18 1 1 CD cord-010119-t1x9gknd 2346 19 , , , cord-010119-t1x9gknd 2346 20 Michelle Michelle NNP cord-010119-t1x9gknd 2346 21 Humphries Humphries NNP cord-010119-t1x9gknd 2346 22 1 1 CD cord-010119-t1x9gknd 2346 23 , , , cord-010119-t1x9gknd 2346 24 Nancy Nancy NNP cord-010119-t1x9gknd 2346 25 Haubert Haubert NNP cord-010119-t1x9gknd 2346 26 1 1 CD cord-010119-t1x9gknd 2346 27 , , , cord-010119-t1x9gknd 2346 28 Ben Ben NNP cord-010119-t1x9gknd 2346 29 Reynolds Reynolds NNP cord-010119-t1x9gknd 2346 30 1 1 CD cord-010119-t1x9gknd 2346 31 , , , cord-010119-t1x9gknd 2346 32 Michael Michael NNP cord-010119-t1x9gknd 2346 33 Phillips Phillips NNP cord-010119-t1x9gknd 2346 34 1 1 CD cord-010119-t1x9gknd 2346 35 , , , cord-010119-t1x9gknd 2346 36 Randall Randall NNP cord-010119-t1x9gknd 2346 37 Spizman Spizman NNP cord-010119-t1x9gknd 2346 38 1 1 CD cord-010119-t1x9gknd 2346 39 , , , cord-010119-t1x9gknd 2346 40 Ralph Ralph NNP cord-010119-t1x9gknd 2346 41 R R NNP cord-010119-t1x9gknd 2346 42 Vassallo Vassallo NNP cord-010119-t1x9gknd 2346 43 2 2 CD cord-010119-t1x9gknd 2346 44 , , , cord-010119-t1x9gknd 2346 45 Hany Hany NNP cord-010119-t1x9gknd 2346 46 Kamel Kamel NNP cord-010119-t1x9gknd 2346 47 2 2 CD cord-010119-t1x9gknd 2346 48 , , , cord-010119-t1x9gknd 2346 49 Sally Sally NNP cord-010119-t1x9gknd 2346 50 Caglioti Caglioti NNP cord-010119-t1x9gknd 2346 51 1 1 CD cord-010119-t1x9gknd 2346 52 , , , cord-010119-t1x9gknd 2346 53 German German NNP cord-010119-t1x9gknd 2346 54 Leparc Leparc NNP cord-010119-t1x9gknd 2346 55 1,3 1,3 CD cord-010119-t1x9gknd 2346 56 and and CC cord-010119-t1x9gknd 2346 57 Phillip Phillip NNP cord-010119-t1x9gknd 2346 58 C C NNP cord-010119-t1x9gknd 2346 59 Williamson Williamson NNP cord-010119-t1x9gknd 2346 60 1 1 CD cord-010119-t1x9gknd 2346 61 . . . cord-010119-t1x9gknd 2347 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 2347 2 completely completely RB cord-010119-t1x9gknd 2347 3 investigated investigate VBN cord-010119-t1x9gknd 2347 4 . . . cord-010119-t1x9gknd 2348 1 The the DT cord-010119-t1x9gknd 2348 2 adolescent adolescent JJ cord-010119-t1x9gknd 2348 3 growth growth NN cord-010119-t1x9gknd 2348 4 spurt spurt NN cord-010119-t1x9gknd 2348 5 , , , cord-010119-t1x9gknd 2348 6 poor poor JJ cord-010119-t1x9gknd 2348 7 nutrition nutrition NN cord-010119-t1x9gknd 2348 8 and and CC cord-010119-t1x9gknd 2348 9 onset onset NN cord-010119-t1x9gknd 2348 10 of of IN cord-010119-t1x9gknd 2348 11 menses mense NNS cord-010119-t1x9gknd 2348 12 increase increase VBP cord-010119-t1x9gknd 2348 13 the the DT cord-010119-t1x9gknd 2348 14 risks risk NNS cord-010119-t1x9gknd 2348 15 of of IN cord-010119-t1x9gknd 2348 16 iron iron NN cord-010119-t1x9gknd 2348 17 depletion depletion NN cord-010119-t1x9gknd 2348 18 in in IN cord-010119-t1x9gknd 2348 19 young young JJ cord-010119-t1x9gknd 2348 20 donors donor NNS cord-010119-t1x9gknd 2348 21 . . . cord-010119-t1x9gknd 2349 1 1 1 CD cord-010119-t1x9gknd 2349 2 New New NNP cord-010119-t1x9gknd 2349 3 studies study NNS cord-010119-t1x9gknd 2349 4 show show VBP cord-010119-t1x9gknd 2349 5 that that IN cord-010119-t1x9gknd 2349 6 teenage teenage JJ cord-010119-t1x9gknd 2349 7 donors donor NNS cord-010119-t1x9gknd 2349 8 who who WP cord-010119-t1x9gknd 2349 9 give give VBP cord-010119-t1x9gknd 2349 10 blood blood NN cord-010119-t1x9gknd 2349 11 frequently frequently RB cord-010119-t1x9gknd 2349 12 may may MD cord-010119-t1x9gknd 2349 13 be be VB cord-010119-t1x9gknd 2349 14 more more RBR cord-010119-t1x9gknd 2349 15 susceptible susceptible JJ cord-010119-t1x9gknd 2349 16 to to IN cord-010119-t1x9gknd 2349 17 becoming become VBG cord-010119-t1x9gknd 2349 18 iron iron NN cord-010119-t1x9gknd 2349 19 deficient deficient JJ cord-010119-t1x9gknd 2349 20 than than IN cord-010119-t1x9gknd 2349 21 older old JJR cord-010119-t1x9gknd 2349 22 repeat repeat NN cord-010119-t1x9gknd 2349 23 donors donor NNS cord-010119-t1x9gknd 2349 24 . . . cord-010119-t1x9gknd 2350 1 2 2 LS cord-010119-t1x9gknd 2351 1 Study Study NNP cord-010119-t1x9gknd 2351 2 Design Design NNP cord-010119-t1x9gknd 2351 3 / / SYM cord-010119-t1x9gknd 2351 4 Methods method NNS cord-010119-t1x9gknd 2351 5 : : : cord-010119-t1x9gknd 2352 1 Over over IN cord-010119-t1x9gknd 2352 2 28,000 28,000 CD cord-010119-t1x9gknd 2352 3 serum serum NN cord-010119-t1x9gknd 2352 4 samples sample NNS cord-010119-t1x9gknd 2352 5 from from IN cord-010119-t1x9gknd 2352 6 donors donor NNS cord-010119-t1x9gknd 2352 7 aged age VBN cord-010119-t1x9gknd 2352 8 16 16 CD cord-010119-t1x9gknd 2352 9 , , , cord-010119-t1x9gknd 2352 10 17 17 CD cord-010119-t1x9gknd 2352 11 and and CC cord-010119-t1x9gknd 2352 12 18 18 CD cord-010119-t1x9gknd 2352 13 years year NNS cord-010119-t1x9gknd 2352 14 were be VBD cord-010119-t1x9gknd 2352 15 analyzed analyze VBN cord-010119-t1x9gknd 2352 16 for for IN cord-010119-t1x9gknd 2352 17 ferritin ferritin NN cord-010119-t1x9gknd 2352 18 levels level NNS cord-010119-t1x9gknd 2352 19 using use VBG cord-010119-t1x9gknd 2352 20 the the DT cord-010119-t1x9gknd 2352 21 Beckman Beckman NNP cord-010119-t1x9gknd 2352 22 Coulter Coulter NNP cord-010119-t1x9gknd 2352 23 AU680 AU680 NNP cord-010119-t1x9gknd 2352 24 instrument instrument NN cord-010119-t1x9gknd 2352 25 and and CC cord-010119-t1x9gknd 2352 26 reagent reagent NN cord-010119-t1x9gknd 2352 27 kit kit NN cord-010119-t1x9gknd 2352 28 . . . cord-010119-t1x9gknd 2353 1 The the DT cord-010119-t1x9gknd 2353 2 anti anti JJ cord-010119-t1x9gknd 2353 3 - - JJ cord-010119-t1x9gknd 2353 4 ferritin ferritin JJ cord-010119-t1x9gknd 2353 5 reagent reagent NN cord-010119-t1x9gknd 2353 6 is be VBZ cord-010119-t1x9gknd 2353 7 a a DT cord-010119-t1x9gknd 2353 8 suspension suspension NN cord-010119-t1x9gknd 2353 9 of of IN cord-010119-t1x9gknd 2353 10 polystyrene polystyrene NN cord-010119-t1x9gknd 2353 11 latex latex NN cord-010119-t1x9gknd 2353 12 particles particle NNS cord-010119-t1x9gknd 2353 13 , , , cord-010119-t1x9gknd 2353 14 of of IN cord-010119-t1x9gknd 2353 15 uniform uniform JJ cord-010119-t1x9gknd 2353 16 size size NN cord-010119-t1x9gknd 2353 17 , , , cord-010119-t1x9gknd 2353 18 coated coat VBN cord-010119-t1x9gknd 2353 19 with with IN cord-010119-t1x9gknd 2353 20 polyclonal polyclonal JJ cord-010119-t1x9gknd 2353 21 rabbit rabbit NN cord-010119-t1x9gknd 2353 22 anti anti JJ cord-010119-t1x9gknd 2353 23 - - JJ cord-010119-t1x9gknd 2353 24 ferritin ferritin JJ cord-010119-t1x9gknd 2353 25 antibody antibody NN cord-010119-t1x9gknd 2353 26 . . . cord-010119-t1x9gknd 2354 1 Immune immune JJ cord-010119-t1x9gknd 2354 2 complexes complex NNS cord-010119-t1x9gknd 2354 3 formed form VBN cord-010119-t1x9gknd 2354 4 in in IN cord-010119-t1x9gknd 2354 5 solution solution NN cord-010119-t1x9gknd 2354 6 scatter scatter NN cord-010119-t1x9gknd 2354 7 light light NN cord-010119-t1x9gknd 2354 8 in in IN cord-010119-t1x9gknd 2354 9 proportion proportion NN cord-010119-t1x9gknd 2354 10 to to IN cord-010119-t1x9gknd 2354 11 their -PRON- PRP$ cord-010119-t1x9gknd 2354 12 size size NN cord-010119-t1x9gknd 2354 13 , , , cord-010119-t1x9gknd 2354 14 shape shape NN cord-010119-t1x9gknd 2354 15 and and CC cord-010119-t1x9gknd 2354 16 concentration concentration NN cord-010119-t1x9gknd 2354 17 . . . cord-010119-t1x9gknd 2355 1 The the DT cord-010119-t1x9gknd 2355 2 decrease decrease NN cord-010119-t1x9gknd 2355 3 in in IN cord-010119-t1x9gknd 2355 4 light light JJ cord-010119-t1x9gknd 2355 5 intensity intensity NN cord-010119-t1x9gknd 2355 6 is be VBZ cord-010119-t1x9gknd 2355 7 measured measure VBN cord-010119-t1x9gknd 2355 8 spectrophotometrically spectrophotometrically RB cord-010119-t1x9gknd 2355 9 . . . cord-010119-t1x9gknd 2356 1 3 3 LS cord-010119-t1x9gknd 2357 1 Results result NNS cord-010119-t1x9gknd 2357 2 / / SYM cord-010119-t1x9gknd 2357 3 Findings finding NNS cord-010119-t1x9gknd 2357 4 : : : cord-010119-t1x9gknd 2358 1 Background Background NNP cord-010119-t1x9gknd 2358 2 / / SYM cord-010119-t1x9gknd 2358 3 Case Case NNP cord-010119-t1x9gknd 2358 4 Studies Studies NNPS cord-010119-t1x9gknd 2358 5 : : : cord-010119-t1x9gknd 2359 1 The the DT cord-010119-t1x9gknd 2359 2 risk risk NN cord-010119-t1x9gknd 2359 3 of of IN cord-010119-t1x9gknd 2359 4 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2359 5 ( ( -LRB- cord-010119-t1x9gknd 2359 6 CV cv NN cord-010119-t1x9gknd 2359 7 ) ) -RRB- cord-010119-t1x9gknd 2359 8 disease disease NN cord-010119-t1x9gknd 2359 9 in in IN cord-010119-t1x9gknd 2359 10 adults adult NNS cord-010119-t1x9gknd 2359 11 can can MD cord-010119-t1x9gknd 2359 12 often often RB cord-010119-t1x9gknd 2359 13 be be VB cord-010119-t1x9gknd 2359 14 identified identify VBN cord-010119-t1x9gknd 2359 15 during during IN cord-010119-t1x9gknd 2359 16 adolescent adolescent JJ cord-010119-t1x9gknd 2359 17 years year NNS cord-010119-t1x9gknd 2359 18 . . . cord-010119-t1x9gknd 2360 1 The the DT cord-010119-t1x9gknd 2360 2 presence presence NN cord-010119-t1x9gknd 2360 3 of of IN cord-010119-t1x9gknd 2360 4 even even RB cord-010119-t1x9gknd 2360 5 borderline borderline JJ cord-010119-t1x9gknd 2360 6 levels level NNS cord-010119-t1x9gknd 2360 7 of of IN cord-010119-t1x9gknd 2360 8 multiple multiple JJ cord-010119-t1x9gknd 2360 9 risk risk NN cord-010119-t1x9gknd 2360 10 factors factor NNS cord-010119-t1x9gknd 2360 11 increases increase VBZ cord-010119-t1x9gknd 2360 12 the the DT cord-010119-t1x9gknd 2360 13 likelihood likelihood NN cord-010119-t1x9gknd 2360 14 of of IN cord-010119-t1x9gknd 2360 15 a a DT cord-010119-t1x9gknd 2360 16 CV cv NN cord-010119-t1x9gknd 2360 17 event event NN cord-010119-t1x9gknd 2360 18 . . . cord-010119-t1x9gknd 2361 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2361 2 blood blood NN cord-010119-t1x9gknd 2361 3 program program NN cord-010119-t1x9gknd 2361 4 routinely routinely RB cord-010119-t1x9gknd 2361 5 provides provide VBZ cord-010119-t1x9gknd 2361 6 a a DT cord-010119-t1x9gknd 2361 7 total total JJ cord-010119-t1x9gknd 2361 8 non non JJ cord-010119-t1x9gknd 2361 9 - - JJ cord-010119-t1x9gknd 2361 10 fasting fasting JJ cord-010119-t1x9gknd 2361 11 cholesterol cholesterol NN cord-010119-t1x9gknd 2361 12 ( ( -LRB- cord-010119-t1x9gknd 2361 13 TC TC NNP cord-010119-t1x9gknd 2361 14 ) ) -RRB- cord-010119-t1x9gknd 2361 15 and and CC cord-010119-t1x9gknd 2361 16 blood blood NN cord-010119-t1x9gknd 2361 17 pressure pressure NN cord-010119-t1x9gknd 2361 18 ( ( -LRB- cord-010119-t1x9gknd 2361 19 BP BP NNP cord-010119-t1x9gknd 2361 20 ) ) -RRB- cord-010119-t1x9gknd 2361 21 measurement measurement NN cord-010119-t1x9gknd 2361 22 for for IN cord-010119-t1x9gknd 2361 23 all all DT cord-010119-t1x9gknd 2361 24 blood blood NN cord-010119-t1x9gknd 2361 25 donors donor NNS cord-010119-t1x9gknd 2361 26 . . . cord-010119-t1x9gknd 2362 1 We -PRON- PRP cord-010119-t1x9gknd 2362 2 added add VBD cord-010119-t1x9gknd 2362 3 glycated glycated JJ cord-010119-t1x9gknd 2362 4 hemoglobin hemoglobin NN cord-010119-t1x9gknd 2362 5 ( ( -LRB- cord-010119-t1x9gknd 2362 6 HbA1c HbA1c NNP cord-010119-t1x9gknd 2362 7 ) ) -RRB- cord-010119-t1x9gknd 2362 8 determination determination NN cord-010119-t1x9gknd 2362 9 and and CC cord-010119-t1x9gknd 2362 10 performed perform VBN cord-010119-t1x9gknd 2362 11 analyses analysis NNS cord-010119-t1x9gknd 2362 12 of of IN cord-010119-t1x9gknd 2362 13 the the DT cord-010119-t1x9gknd 2362 14 prevalence prevalence NN cord-010119-t1x9gknd 2362 15 of of IN cord-010119-t1x9gknd 2362 16 abnormal abnormal JJ cord-010119-t1x9gknd 2362 17 ( ( -LRB- cord-010119-t1x9gknd 2362 18 borderline borderline JJ cord-010119-t1x9gknd 2362 19 or or CC cord-010119-t1x9gknd 2362 20 elevated elevated JJ cord-010119-t1x9gknd 2362 21 ) ) -RRB- cord-010119-t1x9gknd 2362 22 levels level NNS cord-010119-t1x9gknd 2362 23 of of IN cord-010119-t1x9gknd 2362 24 multiple multiple JJ cord-010119-t1x9gknd 2362 25 risk risk NN cord-010119-t1x9gknd 2362 26 factors factor NNS cord-010119-t1x9gknd 2362 27 among among IN cord-010119-t1x9gknd 2362 28 21,007 21,007 CD cord-010119-t1x9gknd 2362 29 adolescents adolescent NNS cord-010119-t1x9gknd 2362 30 ( ( -LRB- cord-010119-t1x9gknd 2362 31 ages age NNS cord-010119-t1x9gknd 2362 32 16 16 CD cord-010119-t1x9gknd 2362 33 - - SYM cord-010119-t1x9gknd 2362 34 19 19 CD cord-010119-t1x9gknd 2362 35 ; ; : cord-010119-t1x9gknd 2362 36 61.5 61.5 CD cord-010119-t1x9gknd 2362 37 % % NN cord-010119-t1x9gknd 2362 38 female female NN cord-010119-t1x9gknd 2362 39 ) ) -RRB- cord-010119-t1x9gknd 2362 40 who who WP cord-010119-t1x9gknd 2362 41 donated donate VBD cord-010119-t1x9gknd 2362 42 blood blood NN cord-010119-t1x9gknd 2362 43 from from IN cord-010119-t1x9gknd 2362 44 2015 2015 CD cord-010119-t1x9gknd 2362 45 to to IN cord-010119-t1x9gknd 2362 46 2016 2016 CD cord-010119-t1x9gknd 2362 47 . . . cord-010119-t1x9gknd 2363 1 Study Study NNP cord-010119-t1x9gknd 2363 2 Design Design NNP cord-010119-t1x9gknd 2363 3 / / SYM cord-010119-t1x9gknd 2363 4 Method method NN cord-010119-t1x9gknd 2363 5 : : : cord-010119-t1x9gknd 2364 1 Abnormal abnormal JJ cord-010119-t1x9gknd 2364 2 risk risk NN cord-010119-t1x9gknd 2364 3 factor factor NN cord-010119-t1x9gknd 2364 4 levels level NNS cord-010119-t1x9gknd 2364 5 were be VBD cord-010119-t1x9gknd 2364 6 defined define VBN cord-010119-t1x9gknd 2364 7 as as IN cord-010119-t1x9gknd 2364 8 HbA1c HbA1c NNP cord-010119-t1x9gknd 2364 9 ! ! . cord-010119-t1x9gknd 2364 10 5.7 5.7 CD cord-010119-t1x9gknd 2364 11 % % NN cord-010119-t1x9gknd 2364 12 , , , cord-010119-t1x9gknd 2364 13 SBP SBP NNP cord-010119-t1x9gknd 2364 14 / / SYM cord-010119-t1x9gknd 2364 15 DBP DBP NNP cord-010119-t1x9gknd 2364 16 ! ! . cord-010119-t1x9gknd 2365 1 120/80 120/80 CD cord-010119-t1x9gknd 2366 1 mm mm NNP cord-010119-t1x9gknd 2367 1 Hg Hg NNP cord-010119-t1x9gknd 2367 2 and and CC cord-010119-t1x9gknd 2367 3 TC tc NN cord-010119-t1x9gknd 2367 4 ! ! . cord-010119-t1x9gknd 2368 1 170mg 170mg NNP cord-010119-t1x9gknd 2368 2 / / SYM cord-010119-t1x9gknd 2368 3 dL dL NNP cord-010119-t1x9gknd 2368 4 , , , cord-010119-t1x9gknd 2368 5 as as IN cord-010119-t1x9gknd 2368 6 suggested suggest VBN cord-010119-t1x9gknd 2368 7 by by IN cord-010119-t1x9gknd 2368 8 the the DT cord-010119-t1x9gknd 2368 9 American American NNP cord-010119-t1x9gknd 2368 10 Heart Heart NNP cord-010119-t1x9gknd 2368 11 Association Association NNP cord-010119-t1x9gknd 2368 12 for for IN cord-010119-t1x9gknd 2368 13 adolescents adolescent NNS cord-010119-t1x9gknd 2368 14 . . . cord-010119-t1x9gknd 2369 1 The the DT cord-010119-t1x9gknd 2369 2 presence presence NN cord-010119-t1x9gknd 2369 3 of of IN cord-010119-t1x9gknd 2369 4 isolated isolate VBN cord-010119-t1x9gknd 2369 5 risk risk NN cord-010119-t1x9gknd 2369 6 factors factor NNS cord-010119-t1x9gknd 2369 7 was be VBD cord-010119-t1x9gknd 2369 8 defined define VBN cord-010119-t1x9gknd 2369 9 as as IN cord-010119-t1x9gknd 2369 10 one one CD cord-010119-t1x9gknd 2369 11 single single JJ cord-010119-t1x9gknd 2369 12 abnormal abnormal JJ cord-010119-t1x9gknd 2369 13 risk risk NN cord-010119-t1x9gknd 2369 14 factor factor NN cord-010119-t1x9gknd 2369 15 per per IN cord-010119-t1x9gknd 2369 16 individual individual NN cord-010119-t1x9gknd 2369 17 . . . cord-010119-t1x9gknd 2370 1 Clustering clustering NN cord-010119-t1x9gknd 2370 2 of of IN cord-010119-t1x9gknd 2370 3 risk risk NN cord-010119-t1x9gknd 2370 4 factors factor NNS cord-010119-t1x9gknd 2370 5 was be VBD cord-010119-t1x9gknd 2370 6 defined define VBN cord-010119-t1x9gknd 2370 7 as as IN cord-010119-t1x9gknd 2370 8 the the DT cord-010119-t1x9gknd 2370 9 presence presence NN cord-010119-t1x9gknd 2370 10 of of IN cord-010119-t1x9gknd 2370 11 2 2 CD cord-010119-t1x9gknd 2370 12 or or CC cord-010119-t1x9gknd 2370 13 more more RBR cord-010119-t1x9gknd 2370 14 abnormal abnormal JJ cord-010119-t1x9gknd 2370 15 risk risk NN cord-010119-t1x9gknd 2370 16 factors factor NNS cord-010119-t1x9gknd 2370 17 in in IN cord-010119-t1x9gknd 2370 18 the the DT cord-010119-t1x9gknd 2370 19 same same JJ cord-010119-t1x9gknd 2370 20 individual individual NN cord-010119-t1x9gknd 2370 21 . . . cord-010119-t1x9gknd 2371 1 Donor donor NN cord-010119-t1x9gknd 2371 2 sex sex NN cord-010119-t1x9gknd 2371 3 was be VBD cord-010119-t1x9gknd 2371 4 recorded record VBN cord-010119-t1x9gknd 2371 5 at at IN cord-010119-t1x9gknd 2371 6 the the DT cord-010119-t1x9gknd 2371 7 time time NN cord-010119-t1x9gknd 2371 8 of of IN cord-010119-t1x9gknd 2371 9 donation donation NN cord-010119-t1x9gknd 2371 10 . . . cord-010119-t1x9gknd 2372 1 Results/ Results/ . cord-010119-t1x9gknd 2373 1 Finding finding NN cord-010119-t1x9gknd 2373 2 : : : cord-010119-t1x9gknd 2374 1 Table table NN cord-010119-t1x9gknd 2374 2 1 1 CD cord-010119-t1x9gknd 2374 3 shows show VBZ cord-010119-t1x9gknd 2374 4 the the DT cord-010119-t1x9gknd 2374 5 prevalence prevalence NN cord-010119-t1x9gknd 2374 6 of of IN cord-010119-t1x9gknd 2374 7 isolated isolated JJ cord-010119-t1x9gknd 2374 8 abnormal abnormal JJ cord-010119-t1x9gknd 2374 9 risk risk NN cord-010119-t1x9gknd 2374 10 factors factor NNS cord-010119-t1x9gknd 2374 11 and and CC cord-010119-t1x9gknd 2374 12 the the DT cord-010119-t1x9gknd 2374 13 prevalence prevalence NN cord-010119-t1x9gknd 2374 14 of of IN cord-010119-t1x9gknd 2374 15 abnormal abnormal JJ cord-010119-t1x9gknd 2374 16 risk risk NN cord-010119-t1x9gknd 2374 17 factor factor NN cord-010119-t1x9gknd 2374 18 clustering cluster VBG cord-010119-t1x9gknd 2374 19 in in IN cord-010119-t1x9gknd 2374 20 the the DT cord-010119-t1x9gknd 2374 21 study study NN cord-010119-t1x9gknd 2374 22 cohort cohort NN cord-010119-t1x9gknd 2374 23 . . . cord-010119-t1x9gknd 2375 1 Overall overall RB cord-010119-t1x9gknd 2375 2 , , , cord-010119-t1x9gknd 2375 3 11,283 11,283 CD cord-010119-t1x9gknd 2375 4 ( ( -LRB- cord-010119-t1x9gknd 2375 5 53.7 53.7 CD cord-010119-t1x9gknd 2375 6 % % NN cord-010119-t1x9gknd 2375 7 ) ) -RRB- cord-010119-t1x9gknd 2375 8 adolescents adolescent NNS cord-010119-t1x9gknd 2375 9 had have VBD cord-010119-t1x9gknd 2375 10 at at RB cord-010119-t1x9gknd 2375 11 least least RBS cord-010119-t1x9gknd 2375 12 one one CD cord-010119-t1x9gknd 2375 13 abnormal abnormal JJ cord-010119-t1x9gknd 2375 14 risk risk NN cord-010119-t1x9gknd 2375 15 factor factor NN cord-010119-t1x9gknd 2375 16 ( ( -LRB- cord-010119-t1x9gknd 2375 17 61.8 61.8 CD cord-010119-t1x9gknd 2375 18 % % NN cord-010119-t1x9gknd 2375 19 of of IN cord-010119-t1x9gknd 2375 20 males male NNS cord-010119-t1x9gknd 2375 21 , , , cord-010119-t1x9gknd 2375 22 48.6 48.6 CD cord-010119-t1x9gknd 2375 23 % % NN cord-010119-t1x9gknd 2375 24 of of IN cord-010119-t1x9gknd 2375 25 females female NNS cord-010119-t1x9gknd 2375 26 ) ) -RRB- cord-010119-t1x9gknd 2375 27 . . . cord-010119-t1x9gknd 2376 1 Of of IN cord-010119-t1x9gknd 2376 2 these these DT cord-010119-t1x9gknd 2376 3 , , , cord-010119-t1x9gknd 2376 4 8,709 8,709 CD cord-010119-t1x9gknd 2376 5 adolescents adolescent NNS cord-010119-t1x9gknd 2376 6 had have VBD cord-010119-t1x9gknd 2376 7 isolated isolate VBN cord-010119-t1x9gknd 2376 8 abnormal abnormal JJ cord-010119-t1x9gknd 2376 9 risk risk NN cord-010119-t1x9gknd 2376 10 factors factor NNS cord-010119-t1x9gknd 2376 11 , , , cord-010119-t1x9gknd 2376 12 and and CC cord-010119-t1x9gknd 2376 13 2,574 2,574 CD cord-010119-t1x9gknd 2376 14 adolescents adolescent NNS cord-010119-t1x9gknd 2376 15 had have VBD cord-010119-t1x9gknd 2376 16 clustering cluster VBG cord-010119-t1x9gknd 2376 17 risk risk NN cord-010119-t1x9gknd 2376 18 factors factor NNS cord-010119-t1x9gknd 2376 19 . . . cord-010119-t1x9gknd 2377 1 Higher high JJR cord-010119-t1x9gknd 2377 2 proportions proportion NNS cord-010119-t1x9gknd 2377 3 of of IN cord-010119-t1x9gknd 2377 4 males male NNS cord-010119-t1x9gknd 2377 5 were be VBD cord-010119-t1x9gknd 2377 6 in in IN cord-010119-t1x9gknd 2377 7 the the DT cord-010119-t1x9gknd 2377 8 abnormal abnormal JJ cord-010119-t1x9gknd 2377 9 BP BP NNP cord-010119-t1x9gknd 2377 10 alone alone RB cord-010119-t1x9gknd 2377 11 , , , cord-010119-t1x9gknd 2377 12 Background Background NNP cord-010119-t1x9gknd 2377 13 / / SYM cord-010119-t1x9gknd 2377 14 Case Case NNP cord-010119-t1x9gknd 2377 15 Studies Studies NNPS cord-010119-t1x9gknd 2377 16 : : : cord-010119-t1x9gknd 2377 17 Pre pre JJ cord-010119-t1x9gknd 2377 18 - - JJ cord-010119-t1x9gknd 2377 19 donation donation NN cord-010119-t1x9gknd 2377 20 determination determination NN cord-010119-t1x9gknd 2377 21 of of IN cord-010119-t1x9gknd 2377 22 hemoglobin hemoglobin NN cord-010119-t1x9gknd 2377 23 ( ( -LRB- cord-010119-t1x9gknd 2377 24 Hb Hb NNP cord-010119-t1x9gknd 2377 25 ) ) -RRB- cord-010119-t1x9gknd 2377 26 level level NN cord-010119-t1x9gknd 2377 27 in in IN cord-010119-t1x9gknd 2377 28 candidate candidate NN cord-010119-t1x9gknd 2377 29 blood blood NN cord-010119-t1x9gknd 2377 30 donors donor NNS cord-010119-t1x9gknd 2377 31 is be VBZ cord-010119-t1x9gknd 2377 32 a a DT cord-010119-t1x9gknd 2377 33 pre pre JJ cord-010119-t1x9gknd 2377 34 - - JJ cord-010119-t1x9gknd 2377 35 requisite requisite JJ cord-010119-t1x9gknd 2377 36 in in IN cord-010119-t1x9gknd 2377 37 the the DT cord-010119-t1x9gknd 2377 38 majority majority NN cord-010119-t1x9gknd 2377 39 of of IN cord-010119-t1x9gknd 2377 40 blood blood NN cord-010119-t1x9gknd 2377 41 services service NNS cord-010119-t1x9gknd 2377 42 and and CC cord-010119-t1x9gknd 2377 43 is be VBZ cord-010119-t1x9gknd 2377 44 used use VBN cord-010119-t1x9gknd 2377 45 to to TO cord-010119-t1x9gknd 2377 46 ensure ensure VB cord-010119-t1x9gknd 2377 47 donor donor NN cord-010119-t1x9gknd 2377 48 safety safety NN cord-010119-t1x9gknd 2377 49 and and CC cord-010119-t1x9gknd 2377 50 blood blood NN cord-010119-t1x9gknd 2377 51 product product NN cord-010119-t1x9gknd 2377 52 quality quality NN cord-010119-t1x9gknd 2377 53 . . . cord-010119-t1x9gknd 2378 1 However however RB cord-010119-t1x9gknd 2378 2 , , , cord-010119-t1x9gknd 2378 3 a a DT cord-010119-t1x9gknd 2378 4 variety variety NN cord-010119-t1x9gknd 2378 5 of of IN cord-010119-t1x9gknd 2378 6 Hb Hb NNP cord-010119-t1x9gknd 2378 7 testing testing NN cord-010119-t1x9gknd 2378 8 strategies strategy NNS cord-010119-t1x9gknd 2378 9 are be VBP cord-010119-t1x9gknd 2378 10 used use VBN cord-010119-t1x9gknd 2378 11 across across IN cord-010119-t1x9gknd 2378 12 blood blood NN cord-010119-t1x9gknd 2378 13 services service NNS cord-010119-t1x9gknd 2378 14 to to TO cord-010119-t1x9gknd 2378 15 satisfy satisfy VB cord-010119-t1x9gknd 2378 16 this this DT cord-010119-t1x9gknd 2378 17 selection selection NN cord-010119-t1x9gknd 2378 18 criterion criterion NN cord-010119-t1x9gknd 2378 19 . . . cord-010119-t1x9gknd 2379 1 This this DT cord-010119-t1x9gknd 2379 2 study study NN cord-010119-t1x9gknd 2379 3 aimed aim VBD cord-010119-t1x9gknd 2379 4 to to TO cord-010119-t1x9gknd 2379 5 identify identify VB cord-010119-t1x9gknd 2379 6 how how WRB cord-010119-t1x9gknd 2379 7 Hb Hb NNP cord-010119-t1x9gknd 2379 8 screening screening NN cord-010119-t1x9gknd 2379 9 practices practice NNS cord-010119-t1x9gknd 2379 10 vary vary VBP cord-010119-t1x9gknd 2379 11 across across IN cord-010119-t1x9gknd 2379 12 blood blood NN cord-010119-t1x9gknd 2379 13 donation donation NN cord-010119-t1x9gknd 2379 14 services service NNS cord-010119-t1x9gknd 2379 15 and and CC cord-010119-t1x9gknd 2379 16 to to TO cord-010119-t1x9gknd 2379 17 what what WDT cord-010119-t1x9gknd 2379 18 extent extent NN cord-010119-t1x9gknd 2379 19 they -PRON- PRP cord-010119-t1x9gknd 2379 20 influence influence VBP cord-010119-t1x9gknd 2379 21 deferral deferral NN cord-010119-t1x9gknd 2379 22 rates rate NNS cord-010119-t1x9gknd 2379 23 for for IN cord-010119-t1x9gknd 2379 24 low low JJ cord-010119-t1x9gknd 2379 25 Hb Hb NNP cord-010119-t1x9gknd 2379 26 . . . cord-010119-t1x9gknd 2380 1 Study Study NNP cord-010119-t1x9gknd 2380 2 Design Design NNP cord-010119-t1x9gknd 2380 3 / / SYM cord-010119-t1x9gknd 2380 4 Method method NN cord-010119-t1x9gknd 2380 5 : : : cord-010119-t1x9gknd 2381 1 An an DT cord-010119-t1x9gknd 2381 2 online online JJ cord-010119-t1x9gknd 2381 3 survey survey NN cord-010119-t1x9gknd 2381 4 was be VBD cord-010119-t1x9gknd 2381 5 performed perform VBN cord-010119-t1x9gknd 2381 6 among among IN cord-010119-t1x9gknd 2381 7 members member NNS cord-010119-t1x9gknd 2381 8 of of IN cord-010119-t1x9gknd 2381 9 the the DT cord-010119-t1x9gknd 2381 10 Biomedical Biomedical NNP cord-010119-t1x9gknd 2381 11 Excellence Excellence NNP cord-010119-t1x9gknd 2381 12 for for IN cord-010119-t1x9gknd 2381 13 Safer Safer NNP cord-010119-t1x9gknd 2381 14 Transfusion Transfusion NNP cord-010119-t1x9gknd 2381 15 ( ( -LRB- cord-010119-t1x9gknd 2381 16 BEST BEST NNP cord-010119-t1x9gknd 2381 17 ) ) -RRB- cord-010119-t1x9gknd 2381 18 Collaborative collaborative NN cord-010119-t1x9gknd 2381 19 . . . cord-010119-t1x9gknd 2382 1 Additionally additionally RB cord-010119-t1x9gknd 2382 2 , , , cord-010119-t1x9gknd 2382 3 data datum NNS cord-010119-t1x9gknd 2382 4 from from IN cord-010119-t1x9gknd 2382 5 literature literature NN cord-010119-t1x9gknd 2382 6 were be VBD cord-010119-t1x9gknd 2382 7 used use VBN cord-010119-t1x9gknd 2382 8 to to TO cord-010119-t1x9gknd 2382 9 extend extend VB cord-010119-t1x9gknd 2382 10 the the DT cord-010119-t1x9gknd 2382 11 dataset dataset NN cord-010119-t1x9gknd 2382 12 . . . cord-010119-t1x9gknd 2383 1 The the DT cord-010119-t1x9gknd 2383 2 survey survey NN cord-010119-t1x9gknd 2383 3 involved involve VBD cord-010119-t1x9gknd 2383 4 a a DT cord-010119-t1x9gknd 2383 5 detailed detailed JJ cord-010119-t1x9gknd 2383 6 assessment assessment NN cord-010119-t1x9gknd 2383 7 of of IN cord-010119-t1x9gknd 2383 8 Hb Hb NNP cord-010119-t1x9gknd 2383 9 screening screening NN cord-010119-t1x9gknd 2383 10 practices practice NNS cord-010119-t1x9gknd 2383 11 , , , cord-010119-t1x9gknd 2383 12 numbers number NNS cord-010119-t1x9gknd 2383 13 of of IN cord-010119-t1x9gknd 2383 14 donations donation NNS cord-010119-t1x9gknd 2383 15 and and CC cord-010119-t1x9gknd 2383 16 low low JJ cord-010119-t1x9gknd 2383 17 Hb Hb NNP cord-010119-t1x9gknd 2383 18 deferrals deferral NNS cord-010119-t1x9gknd 2383 19 for for IN cord-010119-t1x9gknd 2383 20 male male JJ cord-010119-t1x9gknd 2383 21 and and CC cord-010119-t1x9gknd 2383 22 female female JJ cord-010119-t1x9gknd 2383 23 donors donor NNS cord-010119-t1x9gknd 2383 24 separately separately RB cord-010119-t1x9gknd 2383 25 . . . cord-010119-t1x9gknd 2384 1 Multivariable multivariable JJ cord-010119-t1x9gknd 2384 2 negative negative JJ cord-010119-t1x9gknd 2384 3 - - HYPH cord-010119-t1x9gknd 2384 4 binomial binomial NN cord-010119-t1x9gknd 2384 5 regression regression NN cord-010119-t1x9gknd 2384 6 models model NNS cord-010119-t1x9gknd 2384 7 were be VBD cord-010119-t1x9gknd 2384 8 built build VBN cord-010119-t1x9gknd 2384 9 to to TO cord-010119-t1x9gknd 2384 10 estimate estimate VB cord-010119-t1x9gknd 2384 11 the the DT cord-010119-t1x9gknd 2384 12 adjusted adjust VBN cord-010119-t1x9gknd 2384 13 effects effect NNS cord-010119-t1x9gknd 2384 14 of of IN cord-010119-t1x9gknd 2384 15 minimum minimum JJ cord-010119-t1x9gknd 2384 16 donation donation NN cord-010119-t1x9gknd 2384 17 intervals interval NNS cord-010119-t1x9gknd 2384 18 , , , cord-010119-t1x9gknd 2384 19 Hb Hb NNP cord-010119-t1x9gknd 2384 20 cutoffs cutoff NNS cord-010119-t1x9gknd 2384 21 ( ( -LRB- cord-010119-t1x9gknd 2384 22 high high JJ cord-010119-t1x9gknd 2384 23 / / SYM cord-010119-t1x9gknd 2384 24 low low JJ cord-010119-t1x9gknd 2384 25 with with IN cord-010119-t1x9gknd 2384 26 high high JJ cord-010119-t1x9gknd 2384 27 defined define VBN cord-010119-t1x9gknd 2384 28 as as IN cord-010119-t1x9gknd 2384 29 ! ! . cord-010119-t1x9gknd 2385 1 13.5 13.5 CD cord-010119-t1x9gknd 2385 2 g g NN cord-010119-t1x9gknd 2385 3 / / SYM cord-010119-t1x9gknd 2385 4 dL dl NN cord-010119-t1x9gknd 2385 5 for for IN cord-010119-t1x9gknd 2385 6 men man NNS cord-010119-t1x9gknd 2385 7 and and CC cord-010119-t1x9gknd 2385 8 ! ! . cord-010119-t1x9gknd 2386 1 12.5 12.5 CD cord-010119-t1x9gknd 2386 2 g g NN cord-010119-t1x9gknd 2386 3 / / SYM cord-010119-t1x9gknd 2386 4 dL dl NN cord-010119-t1x9gknd 2386 5 for for IN cord-010119-t1x9gknd 2386 6 women woman NNS cord-010119-t1x9gknd 2386 7 ) ) -RRB- cord-010119-t1x9gknd 2386 8 , , , cord-010119-t1x9gknd 2386 9 iron iron NN cord-010119-t1x9gknd 2386 10 monitoring monitoring NN cord-010119-t1x9gknd 2386 11 ( ( -LRB- cord-010119-t1x9gknd 2386 12 Y Y NNP cord-010119-t1x9gknd 2386 13 / / SYM cord-010119-t1x9gknd 2386 14 N N NNP cord-010119-t1x9gknd 2386 15 ) ) -RRB- cord-010119-t1x9gknd 2386 16 , , , cord-010119-t1x9gknd 2386 17 iron iron NN cord-010119-t1x9gknd 2386 18 supplements supplement NNS cord-010119-t1x9gknd 2387 1 ( ( -LRB- cord-010119-t1x9gknd 2387 2 Y Y NNP cord-010119-t1x9gknd 2387 3 / / SYM cord-010119-t1x9gknd 2387 4 N N NNP cord-010119-t1x9gknd 2387 5 providing provide VBG cord-010119-t1x9gknd 2387 6 or or CC cord-010119-t1x9gknd 2387 7 prescribing prescribe VBG cord-010119-t1x9gknd 2387 8 ) ) -RRB- cord-010119-t1x9gknd 2387 9 , , , cord-010119-t1x9gknd 2387 10 and and CC cord-010119-t1x9gknd 2387 11 geographical geographical JJ cord-010119-t1x9gknd 2387 12 location location NN cord-010119-t1x9gknd 2387 13 on on IN cord-010119-t1x9gknd 2387 14 deferral deferral NN cord-010119-t1x9gknd 2387 15 rates rate NNS cord-010119-t1x9gknd 2387 16 due due JJ cord-010119-t1x9gknd 2387 17 to to IN cord-010119-t1x9gknd 2388 1 low low JJ cord-010119-t1x9gknd 2388 2 Hb Hb NNP cord-010119-t1x9gknd 2388 3 . . . cord-010119-t1x9gknd 2389 1 Results/ Results/ . cord-010119-t1x9gknd 2390 1 Finding finding NN cord-010119-t1x9gknd 2390 2 : : : cord-010119-t1x9gknd 2391 1 Data datum NNS cord-010119-t1x9gknd 2391 2 were be VBD cord-010119-t1x9gknd 2391 3 included include VBN cord-010119-t1x9gknd 2391 4 from from IN cord-010119-t1x9gknd 2391 5 52 52 CD cord-010119-t1x9gknd 2391 6 blood blood NN cord-010119-t1x9gknd 2391 7 services service NNS cord-010119-t1x9gknd 2391 8 worldwide worldwide RB cord-010119-t1x9gknd 2391 9 and and CC cord-010119-t1x9gknd 2391 10 complete complete JJ cord-010119-t1x9gknd 2391 11 data datum NNS cord-010119-t1x9gknd 2391 12 were be VBD cord-010119-t1x9gknd 2391 13 available available JJ cord-010119-t1x9gknd 2391 14 for for IN cord-010119-t1x9gknd 2391 15 25 25 CD cord-010119-t1x9gknd 2391 16 blood blood NN cord-010119-t1x9gknd 2391 17 services service NNS cord-010119-t1x9gknd 2391 18 . . . cord-010119-t1x9gknd 2392 1 Deferral deferral NN cord-010119-t1x9gknd 2392 2 percentages percentage NNS cord-010119-t1x9gknd 2392 3 for for IN cord-010119-t1x9gknd 2392 4 low low JJ cord-010119-t1x9gknd 2392 5 Hb Hb NNP cord-010119-t1x9gknd 2392 6 varied varied JJ cord-010119-t1x9gknd 2392 7 from from IN cord-010119-t1x9gknd 2392 8 0.01 0.01 CD cord-010119-t1x9gknd 2392 9 % % NN cord-010119-t1x9gknd 2392 10 to to TO cord-010119-t1x9gknd 2392 11 8.81 8.81 CD cord-010119-t1x9gknd 2392 12 % % NN cord-010119-t1x9gknd 2392 13 among among IN cord-010119-t1x9gknd 2392 14 male male JJ cord-010119-t1x9gknd 2392 15 donors donor NNS cord-010119-t1x9gknd 2392 16 and and CC cord-010119-t1x9gknd 2392 17 0.03 0.03 CD cord-010119-t1x9gknd 2392 18 % % NN cord-010119-t1x9gknd 2392 19 to to IN cord-010119-t1x9gknd 2392 20 46.73 46.73 CD cord-010119-t1x9gknd 2392 21 % % NN cord-010119-t1x9gknd 2392 22 among among IN cord-010119-t1x9gknd 2392 23 female female JJ cord-010119-t1x9gknd 2392 24 donors donor NNS cord-010119-t1x9gknd 2392 25 . . . cord-010119-t1x9gknd 2393 1 Hb Hb NNP cord-010119-t1x9gknd 2393 2 deferral deferral NN cord-010119-t1x9gknd 2393 3 rates rate NNS cord-010119-t1x9gknd 2393 4 were be VBD cord-010119-t1x9gknd 2393 5 notably notably RB cord-010119-t1x9gknd 2393 6 higher high JJR cord-010119-t1x9gknd 2393 7 in in IN cord-010119-t1x9gknd 2393 8 Asian asian JJ cord-010119-t1x9gknd 2393 9 blood blood NN cord-010119-t1x9gknd 2393 10 services service NNS cord-010119-t1x9gknd 2393 11 . . . cord-010119-t1x9gknd 2394 1 Overall overall RB cord-010119-t1x9gknd 2394 2 , , , cord-010119-t1x9gknd 2394 3 iron iron NN cord-010119-t1x9gknd 2394 4 monitoring monitoring NN cord-010119-t1x9gknd 2394 5 was be VBD cord-010119-t1x9gknd 2394 6 associated associate VBN cord-010119-t1x9gknd 2394 7 with with IN cord-010119-t1x9gknd 2394 8 53 53 CD cord-010119-t1x9gknd 2394 9 % % NN cord-010119-t1x9gknd 2394 10 lower low JJR cord-010119-t1x9gknd 2394 11 Hb Hb NNP cord-010119-t1x9gknd 2394 12 deferral deferral NN cord-010119-t1x9gknd 2394 13 rates rate NNS cord-010119-t1x9gknd 2394 14 in in IN cord-010119-t1x9gknd 2394 15 men man NNS cord-010119-t1x9gknd 2394 16 ( ( -LRB- cord-010119-t1x9gknd 2394 17 95 95 CD cord-010119-t1x9gknd 2394 18 % % NN cord-010119-t1x9gknd 2394 19 Confidence confidence NN cord-010119-t1x9gknd 2394 20 Interval interval NN cord-010119-t1x9gknd 2394 21 [ [ -LRB- cord-010119-t1x9gknd 2394 22 CI CI NNP cord-010119-t1x9gknd 2394 23 ] ] -RRB- cord-010119-t1x9gknd 2394 24 11 11 CD cord-010119-t1x9gknd 2394 25 % % NN cord-010119-t1x9gknd 2394 26 to to TO cord-010119-t1x9gknd 2394 27 75 75 CD cord-010119-t1x9gknd 2394 28 % % NN cord-010119-t1x9gknd 2394 29 ) ) -RRB- cord-010119-t1x9gknd 2394 30 and and CC cord-010119-t1x9gknd 2394 31 61 61 CD cord-010119-t1x9gknd 2394 32 % % NN cord-010119-t1x9gknd 2394 33 lower low JJR cord-010119-t1x9gknd 2394 34 rates rate NNS cord-010119-t1x9gknd 2394 35 in in IN cord-010119-t1x9gknd 2394 36 women woman NNS cord-010119-t1x9gknd 2394 37 ( ( -LRB- cord-010119-t1x9gknd 2394 38 95%CI 95%ci CD cord-010119-t1x9gknd 2394 39 15 15 CD cord-010119-t1x9gknd 2394 40 % % NN cord-010119-t1x9gknd 2394 41 to to IN cord-010119-t1x9gknd 2394 42 82 82 CD cord-010119-t1x9gknd 2394 43 % % NN cord-010119-t1x9gknd 2394 44 ) ) -RRB- cord-010119-t1x9gknd 2394 45 . . . cord-010119-t1x9gknd 2395 1 Iron iron NN cord-010119-t1x9gknd 2395 2 supplementation supplementation NN cord-010119-t1x9gknd 2395 3 was be VBD cord-010119-t1x9gknd 2395 4 associated associate VBN cord-010119-t1x9gknd 2395 5 to to IN cord-010119-t1x9gknd 2395 6 57 57 CD cord-010119-t1x9gknd 2395 7 % % NN cord-010119-t1x9gknd 2395 8 lower low JJR cord-010119-t1x9gknd 2395 9 Hb Hb NNP cord-010119-t1x9gknd 2395 10 deferral deferral NN cord-010119-t1x9gknd 2395 11 rates rate NNS cord-010119-t1x9gknd 2395 12 among among IN cord-010119-t1x9gknd 2395 13 women woman NNS cord-010119-t1x9gknd 2395 14 ( ( -LRB- cord-010119-t1x9gknd 2395 15 95%CI 95%ci CD cord-010119-t1x9gknd 2395 16 22 22 CD cord-010119-t1x9gknd 2395 17 % % NN cord-010119-t1x9gknd 2395 18 to to IN cord-010119-t1x9gknd 2395 19 76 76 CD cord-010119-t1x9gknd 2395 20 % % NN cord-010119-t1x9gknd 2395 21 ) ) -RRB- cord-010119-t1x9gknd 2395 22 but but CC cord-010119-t1x9gknd 2395 23 there there EX cord-010119-t1x9gknd 2395 24 was be VBD cord-010119-t1x9gknd 2395 25 no no DT cord-010119-t1x9gknd 2395 26 evidence evidence NN cord-010119-t1x9gknd 2395 27 of of IN cord-010119-t1x9gknd 2395 28 such such PDT cord-010119-t1x9gknd 2395 29 an an DT cord-010119-t1x9gknd 2395 30 effect effect NN cord-010119-t1x9gknd 2395 31 among among IN cord-010119-t1x9gknd 2395 32 men man NNS cord-010119-t1x9gknd 2395 33 ( ( -LRB- cord-010119-t1x9gknd 2395 34 p50.680 p50.680 NN cord-010119-t1x9gknd 2395 35 ) ) -RRB- cord-010119-t1x9gknd 2395 36 . . . cord-010119-t1x9gknd 2396 1 Each each DT cord-010119-t1x9gknd 2396 2 one one CD cord-010119-t1x9gknd 2396 3 - - HYPH cord-010119-t1x9gknd 2396 4 week week NN cord-010119-t1x9gknd 2396 5 increase increase NN cord-010119-t1x9gknd 2396 6 in in IN cord-010119-t1x9gknd 2396 7 minimum minimum JJ cord-010119-t1x9gknd 2396 8 donation donation NN cord-010119-t1x9gknd 2396 9 intervals interval NNS cord-010119-t1x9gknd 2396 10 resulted result VBD cord-010119-t1x9gknd 2396 11 in in IN cord-010119-t1x9gknd 2396 12 8 8 CD cord-010119-t1x9gknd 2396 13 % % NN cord-010119-t1x9gknd 2396 14 lower low JJR cord-010119-t1x9gknd 2396 15 Hb Hb NNP cord-010119-t1x9gknd 2396 16 deferral deferral NN cord-010119-t1x9gknd 2396 17 rates rate NNS cord-010119-t1x9gknd 2396 18 among among IN cord-010119-t1x9gknd 2396 19 women woman NNS cord-010119-t1x9gknd 2396 20 ( ( -LRB- cord-010119-t1x9gknd 2396 21 95%CI 95%ci CD cord-010119-t1x9gknd 2396 22 1 1 CD cord-010119-t1x9gknd 2396 23 % % NN cord-010119-t1x9gknd 2396 24 to to IN cord-010119-t1x9gknd 2396 25 14 14 CD cord-010119-t1x9gknd 2396 26 % % NN cord-010119-t1x9gknd 2396 27 ) ) -RRB- cord-010119-t1x9gknd 2396 28 but but CC cord-010119-t1x9gknd 2396 29 not not RB cord-010119-t1x9gknd 2396 30 among among IN cord-010119-t1x9gknd 2396 31 men man NNS cord-010119-t1x9gknd 2396 32 ( ( -LRB- cord-010119-t1x9gknd 2396 33 p50.454 p50.454 NN cord-010119-t1x9gknd 2396 34 ) ) -RRB- cord-010119-t1x9gknd 2396 35 . . . cord-010119-t1x9gknd 2397 1 At at IN cord-010119-t1x9gknd 2397 2 the the DT cord-010119-t1x9gknd 2397 3 5 5 CD cord-010119-t1x9gknd 2397 4 % % NN cord-010119-t1x9gknd 2397 5 level level NN cord-010119-t1x9gknd 2397 6 of of IN cord-010119-t1x9gknd 2397 7 significance significance NN cord-010119-t1x9gknd 2397 8 , , , cord-010119-t1x9gknd 2397 9 higher high JJR cord-010119-t1x9gknd 2397 10 Hb Hb NNP cord-010119-t1x9gknd 2397 11 cutoffs cutoff NNS cord-010119-t1x9gknd 2397 12 do do VBP cord-010119-t1x9gknd 2397 13 not not RB cord-010119-t1x9gknd 2397 14 appear appear VB cord-010119-t1x9gknd 2397 15 to to TO cord-010119-t1x9gknd 2397 16 have have VB cord-010119-t1x9gknd 2397 17 an an DT cord-010119-t1x9gknd 2397 18 effect effect NN cord-010119-t1x9gknd 2397 19 among among IN cord-010119-t1x9gknd 2397 20 men man NNS cord-010119-t1x9gknd 2397 21 or or CC cord-010119-t1x9gknd 2397 22 women woman NNS cord-010119-t1x9gknd 2397 23 . . . cord-010119-t1x9gknd 2398 1 Conclusion conclusion NN cord-010119-t1x9gknd 2398 2 : : : cord-010119-t1x9gknd 2399 1 The the DT cord-010119-t1x9gknd 2399 2 variation variation NN cord-010119-t1x9gknd 2399 3 in in IN cord-010119-t1x9gknd 2399 4 Hb Hb NNP cord-010119-t1x9gknd 2399 5 deferral deferral NN cord-010119-t1x9gknd 2399 6 rates rate NNS cord-010119-t1x9gknd 2399 7 across across IN cord-010119-t1x9gknd 2399 8 blood blood NN cord-010119-t1x9gknd 2399 9 donation donation NN cord-010119-t1x9gknd 2399 10 services service NNS cord-010119-t1x9gknd 2399 11 can can MD cord-010119-t1x9gknd 2399 12 be be VB cord-010119-t1x9gknd 2399 13 , , , cord-010119-t1x9gknd 2399 14 particularly particularly RB cord-010119-t1x9gknd 2399 15 in in IN cord-010119-t1x9gknd 2399 16 female female JJ cord-010119-t1x9gknd 2399 17 donors donor NNS cord-010119-t1x9gknd 2399 18 , , , cord-010119-t1x9gknd 2399 19 explained explain VBN cord-010119-t1x9gknd 2399 20 by by IN cord-010119-t1x9gknd 2399 21 differences difference NNS cord-010119-t1x9gknd 2399 22 in in IN cord-010119-t1x9gknd 2399 23 Hb Hb NNP cord-010119-t1x9gknd 2399 24 screening screening NN cord-010119-t1x9gknd 2399 25 and and CC cord-010119-t1x9gknd 2399 26 deferral deferral NN cord-010119-t1x9gknd 2399 27 practices practice NNS cord-010119-t1x9gknd 2399 28 . . . cord-010119-t1x9gknd 2400 1 Mitigation mitigation NN cord-010119-t1x9gknd 2400 2 strategies strategy NNS cord-010119-t1x9gknd 2400 3 should should MD cord-010119-t1x9gknd 2400 4 consider consider VB cord-010119-t1x9gknd 2400 5 the the DT cord-010119-t1x9gknd 2400 6 variable variable JJ cord-010119-t1x9gknd 2400 7 response response NN cord-010119-t1x9gknd 2400 8 among among IN cord-010119-t1x9gknd 2400 9 men man NNS cord-010119-t1x9gknd 2400 10 and and CC cord-010119-t1x9gknd 2400 11 women woman NNS cord-010119-t1x9gknd 2400 12 . . . cord-010119-t1x9gknd 2401 1 These these DT cord-010119-t1x9gknd 2401 2 insights insight NNS cord-010119-t1x9gknd 2401 3 can can MD cord-010119-t1x9gknd 2401 4 help help VB cord-010119-t1x9gknd 2401 5 improve improve VB cord-010119-t1x9gknd 2401 6 both both DT cord-010119-t1x9gknd 2401 7 blood blood NN cord-010119-t1x9gknd 2401 8 service service NN cord-010119-t1x9gknd 2401 9 efficiency efficiency NN cord-010119-t1x9gknd 2401 10 and and CC cord-010119-t1x9gknd 2401 11 donor donor NN cord-010119-t1x9gknd 2401 12 care care NN cord-010119-t1x9gknd 2401 13 . . . cord-010119-t1x9gknd 2402 1 were be VBD cord-010119-t1x9gknd 2402 2 : : : cord-010119-t1x9gknd 2402 3 characteristics characteristic NNS cord-010119-t1x9gknd 2402 4 of of IN cord-010119-t1x9gknd 2402 5 donors donor NNS cord-010119-t1x9gknd 2402 6 ( ( -LRB- cord-010119-t1x9gknd 2402 7 age age NN cord-010119-t1x9gknd 2402 8 , , , cord-010119-t1x9gknd 2402 9 sex sex NN cord-010119-t1x9gknd 2402 10 , , , cord-010119-t1x9gknd 2402 11 size size NN cord-010119-t1x9gknd 2402 12 , , , cord-010119-t1x9gknd 2402 13 weight weight NN cord-010119-t1x9gknd 2402 14 , , , cord-010119-t1x9gknd 2402 15 region region NN cord-010119-t1x9gknd 2402 16 ) ) -RRB- cord-010119-t1x9gknd 2402 17 ; ; : cord-010119-t1x9gknd 2402 18 Hb Hb NNP cord-010119-t1x9gknd 2402 19 levels level NNS cord-010119-t1x9gknd 2402 20 , , , cord-010119-t1x9gknd 2402 21 date date NN cord-010119-t1x9gknd 2402 22 and and CC cord-010119-t1x9gknd 2402 23 volume volume NN cord-010119-t1x9gknd 2402 24 of of IN cord-010119-t1x9gknd 2402 25 donation donation NN cord-010119-t1x9gknd 2402 26 for for IN cord-010119-t1x9gknd 2402 27 index index NN cord-010119-t1x9gknd 2402 28 application application NN cord-010119-t1x9gknd 2402 29 and and CC cord-010119-t1x9gknd 2402 30 previous previous JJ cord-010119-t1x9gknd 2402 31 donation donation NN cord-010119-t1x9gknd 2402 32 ; ; : cord-010119-t1x9gknd 2402 33 and and CC cord-010119-t1x9gknd 2402 34 number number NN cord-010119-t1x9gknd 2402 35 of of IN cord-010119-t1x9gknd 2402 36 previous previous JJ cord-010119-t1x9gknd 2402 37 donations donation NNS cord-010119-t1x9gknd 2402 38 ( ( -LRB- cord-010119-t1x9gknd 2402 39 in in IN cord-010119-t1x9gknd 2402 40 the the DT cord-010119-t1x9gknd 2402 41 5 5 CD cord-010119-t1x9gknd 2402 42 previous previous JJ cord-010119-t1x9gknd 2402 43 years year NNS cord-010119-t1x9gknd 2402 44 and and CC cord-010119-t1x9gknd 2402 45 the the DT cord-010119-t1x9gknd 2402 46 lifetime lifetime NN cord-010119-t1x9gknd 2402 47 ) ) -RRB- cord-010119-t1x9gknd 2402 48 . . . cord-010119-t1x9gknd 2403 1 Data datum NNS cord-010119-t1x9gknd 2403 2 were be VBD cord-010119-t1x9gknd 2403 3 analyzed analyze VBN cord-010119-t1x9gknd 2403 4 using use VBG cord-010119-t1x9gknd 2403 5 logistic logistic JJ cord-010119-t1x9gknd 2403 6 regression regression NN cord-010119-t1x9gknd 2403 7 stratified stratify VBN cord-010119-t1x9gknd 2403 8 by by IN cord-010119-t1x9gknd 2403 9 sex sex NN cord-010119-t1x9gknd 2403 10 . . . cord-010119-t1x9gknd 2404 1 Results result NNS cord-010119-t1x9gknd 2405 1 /Finding /finde VBG cord-010119-t1x9gknd 2405 2 : : : cord-010119-t1x9gknd 2406 1 9.15 9.15 CD cord-010119-t1x9gknd 2406 2 % % NN cord-010119-t1x9gknd 2406 3 of of IN cord-010119-t1x9gknd 2406 4 all all DT cord-010119-t1x9gknd 2406 5 candidates candidate NNS cord-010119-t1x9gknd 2406 6 for for IN cord-010119-t1x9gknd 2406 7 WB WB NNP cord-010119-t1x9gknd 2406 8 donation donation NN cord-010119-t1x9gknd 2406 9 were be VBD cord-010119-t1x9gknd 2406 10 deferred defer VBN cord-010119-t1x9gknd 2406 11 in in IN cord-010119-t1x9gknd 2406 12 continental continental JJ cord-010119-t1x9gknd 2406 13 France France NNP cord-010119-t1x9gknd 2406 14 in in IN cord-010119-t1x9gknd 2406 15 2015 2015 CD cord-010119-t1x9gknd 2406 16 . . . cord-010119-t1x9gknd 2407 1 Deferral deferral NN cord-010119-t1x9gknd 2407 2 was be VBD cord-010119-t1x9gknd 2407 3 significantly significantly RB cord-010119-t1x9gknd 2407 4 more more RBR cord-010119-t1x9gknd 2407 5 frequent frequent JJ cord-010119-t1x9gknd 2407 6 in in IN cord-010119-t1x9gknd 2407 7 women woman NNS cord-010119-t1x9gknd 2407 8 ( ( -LRB- cord-010119-t1x9gknd 2407 9 11.16 11.16 CD cord-010119-t1x9gknd 2407 10 % % NN cord-010119-t1x9gknd 2407 11 ) ) -RRB- cord-010119-t1x9gknd 2407 12 than than IN cord-010119-t1x9gknd 2407 13 in in IN cord-010119-t1x9gknd 2407 14 men man NNS cord-010119-t1x9gknd 2407 15 ( ( -LRB- cord-010119-t1x9gknd 2407 16 7.29 7.29 CD cord-010119-t1x9gknd 2407 17 % % NN cord-010119-t1x9gknd 2407 18 ) ) -RRB- cord-010119-t1x9gknd 2407 19 , , , cord-010119-t1x9gknd 2407 20 due due IN cord-010119-t1x9gknd 2407 21 to to IN cord-010119-t1x9gknd 2407 22 anemia anemia NN cord-010119-t1x9gknd 2407 23 in in IN cord-010119-t1x9gknd 2407 24 24.41 24.41 CD cord-010119-t1x9gknd 2407 25 % % NN cord-010119-t1x9gknd 2407 26 of of IN cord-010119-t1x9gknd 2407 27 deferred deferred JJ cord-010119-t1x9gknd 2407 28 women woman NNS cord-010119-t1x9gknd 2407 29 and and CC cord-010119-t1x9gknd 2407 30 9.79 9.79 CD cord-010119-t1x9gknd 2407 31 % % NN cord-010119-t1x9gknd 2407 32 of of IN cord-010119-t1x9gknd 2407 33 deferred deferred JJ cord-010119-t1x9gknd 2407 34 men man NNS cord-010119-t1x9gknd 2407 35 . . . cord-010119-t1x9gknd 2408 1 Plotting plot VBG cord-010119-t1x9gknd 2408 2 mean mean VB cord-010119-t1x9gknd 2408 3 Hb Hb NNP cord-010119-t1x9gknd 2408 4 recovery recovery NN cord-010119-t1x9gknd 2408 5 against against IN cord-010119-t1x9gknd 2408 6 time time NN cord-010119-t1x9gknd 2408 7 showed show VBD cord-010119-t1x9gknd 2408 8 mean mean JJ cord-010119-t1x9gknd 2408 9 recovery recovery NN cord-010119-t1x9gknd 2408 10 times time NNS cord-010119-t1x9gknd 2408 11 ranging range VBG cord-010119-t1x9gknd 2408 12 from from IN cord-010119-t1x9gknd 2408 13 20 20 CD cord-010119-t1x9gknd 2408 14 to to TO cord-010119-t1x9gknd 2408 15 30 30 CD cord-010119-t1x9gknd 2408 16 weeks week NNS cord-010119-t1x9gknd 2408 17 . . . cord-010119-t1x9gknd 2409 1 Analysis analysis NN cord-010119-t1x9gknd 2409 2 ( ( -LRB- cord-010119-t1x9gknd 2409 3 Table table NN cord-010119-t1x9gknd 2409 4 ) ) -RRB- cord-010119-t1x9gknd 2409 5 identified identify VBD cord-010119-t1x9gknd 2409 6 3 3 CD cord-010119-t1x9gknd 2409 7 main main JJ cord-010119-t1x9gknd 2409 8 factors factor NNS cord-010119-t1x9gknd 2409 9 associated associate VBN cord-010119-t1x9gknd 2409 10 with with IN cord-010119-t1x9gknd 2409 11 a a DT cord-010119-t1x9gknd 2409 12 higher high JJR cord-010119-t1x9gknd 2409 13 likelihood likelihood NN cord-010119-t1x9gknd 2409 14 of of IN cord-010119-t1x9gknd 2409 15 Hb Hb NNP cord-010119-t1x9gknd 2409 16 recovery recovery NN cord-010119-t1x9gknd 2409 17 : : : cord-010119-t1x9gknd 2409 18 higher high JJR cord-010119-t1x9gknd 2409 19 logarithm logarithm NN cord-010119-t1x9gknd 2409 20 of of IN cord-010119-t1x9gknd 2409 21 time time NN cord-010119-t1x9gknd 2409 22 since since IN cord-010119-t1x9gknd 2409 23 previous previous JJ cord-010119-t1x9gknd 2409 24 donation donation NN cord-010119-t1x9gknd 2409 25 , , , cord-010119-t1x9gknd 2409 26 lower low JJR cord-010119-t1x9gknd 2409 27 levels level NNS cord-010119-t1x9gknd 2409 28 of of IN cord-010119-t1x9gknd 2409 29 Hb Hb NNP cord-010119-t1x9gknd 2409 30 at at IN cord-010119-t1x9gknd 2409 31 previous previous JJ cord-010119-t1x9gknd 2409 32 donation donation NN cord-010119-t1x9gknd 2409 33 , , , cord-010119-t1x9gknd 2409 34 higher high JJR cord-010119-t1x9gknd 2409 35 number number NN cord-010119-t1x9gknd 2409 36 of of IN cord-010119-t1x9gknd 2409 37 blood blood NN cord-010119-t1x9gknd 2409 38 donations donation NNS cord-010119-t1x9gknd 2409 39 in in IN cord-010119-t1x9gknd 2409 40 the the DT cord-010119-t1x9gknd 2409 41 5 5 CD cord-010119-t1x9gknd 2409 42 previous previous JJ cord-010119-t1x9gknd 2409 43 years year NNS cord-010119-t1x9gknd 2409 44 . . . cord-010119-t1x9gknd 2410 1 Conclusion conclusion NN cord-010119-t1x9gknd 2410 2 : : : cord-010119-t1x9gknd 2411 1 The the DT cord-010119-t1x9gknd 2411 2 3 3 CD cord-010119-t1x9gknd 2411 3 main main JJ cord-010119-t1x9gknd 2411 4 factors factor NNS cord-010119-t1x9gknd 2411 5 associated associate VBN cord-010119-t1x9gknd 2411 6 with with IN cord-010119-t1x9gknd 2411 7 higher high JJR cord-010119-t1x9gknd 2411 8 likelihood likelihood NN cord-010119-t1x9gknd 2411 9 of of IN cord-010119-t1x9gknd 2411 10 Hb Hb NNP cord-010119-t1x9gknd 2411 11 recovery recovery NN cord-010119-t1x9gknd 2411 12 after after IN cord-010119-t1x9gknd 2411 13 WB WB NNP cord-010119-t1x9gknd 2411 14 donation donation NN cord-010119-t1x9gknd 2411 15 are be VBP cord-010119-t1x9gknd 2411 16 probably probably RB cord-010119-t1x9gknd 2411 17 linked link VBN cord-010119-t1x9gknd 2411 18 with with IN cord-010119-t1x9gknd 2411 19 hematopoiesis hematopoiesis NN cord-010119-t1x9gknd 2411 20 stimulation stimulation NN cord-010119-t1x9gknd 2411 21 and and CC cord-010119-t1x9gknd 2411 22 selection selection NN cord-010119-t1x9gknd 2411 23 bias bias NN cord-010119-t1x9gknd 2411 24 among among IN cord-010119-t1x9gknd 2411 25 high high JJ cord-010119-t1x9gknd 2411 26 - - HYPH cord-010119-t1x9gknd 2411 27 frequency frequency NN cord-010119-t1x9gknd 2411 28 donors donor NNS cord-010119-t1x9gknd 2411 29 . . . cord-010119-t1x9gknd 2412 1 Mean mean JJ cord-010119-t1x9gknd 2412 2 times time NNS cord-010119-t1x9gknd 2412 3 required require VBN cord-010119-t1x9gknd 2412 4 for for IN cord-010119-t1x9gknd 2412 5 Hb Hb NNP cord-010119-t1x9gknd 2412 6 recovery recovery NN cord-010119-t1x9gknd 2412 7 were be VBD cord-010119-t1x9gknd 2412 8 long long RB cord-010119-t1x9gknd 2412 9 enough enough RB cord-010119-t1x9gknd 2412 10 to to TO cord-010119-t1x9gknd 2412 11 require require VB cord-010119-t1x9gknd 2412 12 further further JJ cord-010119-t1x9gknd 2412 13 studies study NNS cord-010119-t1x9gknd 2412 14 to to TO cord-010119-t1x9gknd 2412 15 assess assess VB cord-010119-t1x9gknd 2412 16 interdonation interdonation NN cord-010119-t1x9gknd 2412 17 intervals interval NNS cord-010119-t1x9gknd 2412 18 in in IN cord-010119-t1x9gknd 2412 19 France France NNP cord-010119-t1x9gknd 2412 20 . . . cord-010119-t1x9gknd 2413 1 Background Background NNP cord-010119-t1x9gknd 2413 2 / / SYM cord-010119-t1x9gknd 2413 3 Case Case NNP cord-010119-t1x9gknd 2413 4 Studies Studies NNPS cord-010119-t1x9gknd 2413 5 : : : cord-010119-t1x9gknd 2413 6 Red red JJ cord-010119-t1x9gknd 2413 7 blood blood NN cord-010119-t1x9gknd 2413 8 cell cell NN cord-010119-t1x9gknd 2413 9 ( ( -LRB- cord-010119-t1x9gknd 2413 10 RBC RBC NNP cord-010119-t1x9gknd 2413 11 ) ) -RRB- cord-010119-t1x9gknd 2413 12 transfusion transfusion NN cord-010119-t1x9gknd 2413 13 has have VBZ cord-010119-t1x9gknd 2413 14 been be VBN cord-010119-t1x9gknd 2413 15 related relate VBN cord-010119-t1x9gknd 2413 16 to to IN cord-010119-t1x9gknd 2413 17 thrombo thrombo NN cord-010119-t1x9gknd 2413 18 - - HYPH cord-010119-t1x9gknd 2413 19 embolic embolic JJ cord-010119-t1x9gknd 2413 20 events event NNS cord-010119-t1x9gknd 2413 21 . . . cord-010119-t1x9gknd 2414 1 Microvesicles microvesicle NNS cord-010119-t1x9gknd 2414 2 in in IN cord-010119-t1x9gknd 2414 3 the the DT cord-010119-t1x9gknd 2414 4 RBC RBC NNP cord-010119-t1x9gknd 2414 5 product product NN cord-010119-t1x9gknd 2414 6 may may MD cord-010119-t1x9gknd 2414 7 support support VB cord-010119-t1x9gknd 2414 8 coagulation coagulation NN cord-010119-t1x9gknd 2414 9 , , , cord-010119-t1x9gknd 2414 10 which which WDT cord-010119-t1x9gknd 2414 11 in in IN cord-010119-t1x9gknd 2414 12 part part NN cord-010119-t1x9gknd 2414 13 may may MD cord-010119-t1x9gknd 2414 14 depend depend VB cord-010119-t1x9gknd 2414 15 on on IN cord-010119-t1x9gknd 2414 16 storage storage NN cord-010119-t1x9gknd 2414 17 time time NN cord-010119-t1x9gknd 2414 18 because because IN cord-010119-t1x9gknd 2414 19 microvesicles microvesicle NNS cord-010119-t1x9gknd 2414 20 have have VBP cord-010119-t1x9gknd 2414 21 procoagulant procoagulant JJ cord-010119-t1x9gknd 2414 22 effects effect NNS cord-010119-t1x9gknd 2414 23 in in IN cord-010119-t1x9gknd 2414 24 vitro vitro FW cord-010119-t1x9gknd 2414 25 and and CC cord-010119-t1x9gknd 2414 26 the the DT cord-010119-t1x9gknd 2414 27 amount amount NN cord-010119-t1x9gknd 2414 28 of of IN cord-010119-t1x9gknd 2414 29 microvesicles microvesicle NNS cord-010119-t1x9gknd 2414 30 increase increase NN cord-010119-t1x9gknd 2414 31 with with IN cord-010119-t1x9gknd 2414 32 storage storage NN cord-010119-t1x9gknd 2414 33 duration duration NN cord-010119-t1x9gknd 2414 34 . . . cord-010119-t1x9gknd 2415 1 Study Study NNP cord-010119-t1x9gknd 2415 2 Design Design NNP cord-010119-t1x9gknd 2415 3 / / SYM cord-010119-t1x9gknd 2415 4 Method method NN cord-010119-t1x9gknd 2415 5 : : : cord-010119-t1x9gknd 2415 6 We -PRON- PRP cord-010119-t1x9gknd 2415 7 investigated investigate VBD cord-010119-t1x9gknd 2415 8 whether whether IN cord-010119-t1x9gknd 2415 9 transfusion transfusion NN cord-010119-t1x9gknd 2415 10 of of IN cord-010119-t1x9gknd 2415 11 RBCs rbc NNS cord-010119-t1x9gknd 2415 12 containing contain VBG cord-010119-t1x9gknd 2415 13 microvesicles microvesicles NNP cord-010119-t1x9gknd 2415 14 promotes promote VBZ cord-010119-t1x9gknd 2415 15 coagulation coagulation NN cord-010119-t1x9gknd 2415 16 in in IN cord-010119-t1x9gknd 2415 17 human human JJ cord-010119-t1x9gknd 2415 18 recipients recipient NNS cord-010119-t1x9gknd 2415 19 . . . cord-010119-t1x9gknd 2416 1 As as IN cord-010119-t1x9gknd 2416 2 transfusion transfusion NN cord-010119-t1x9gknd 2416 3 is be VBZ cord-010119-t1x9gknd 2416 4 mostly mostly RB cord-010119-t1x9gknd 2416 5 administered administer VBN cord-010119-t1x9gknd 2416 6 to to TO cord-010119-t1x9gknd 2416 7 ill ill JJ cord-010119-t1x9gknd 2416 8 patients patient NNS cord-010119-t1x9gknd 2416 9 , , , cord-010119-t1x9gknd 2416 10 we -PRON- PRP cord-010119-t1x9gknd 2416 11 used use VBD cord-010119-t1x9gknd 2416 12 a a DT cord-010119-t1x9gknd 2416 13 model model NN cord-010119-t1x9gknd 2416 14 of of IN cord-010119-t1x9gknd 2416 15 mild mild JJ cord-010119-t1x9gknd 2416 16 endotoxemia endotoxemia NN cord-010119-t1x9gknd 2416 17 . . . cord-010119-t1x9gknd 2417 1 Eighteen eighteen CD cord-010119-t1x9gknd 2417 2 healthy healthy JJ cord-010119-t1x9gknd 2417 3 volunteers volunteer NNS cord-010119-t1x9gknd 2417 4 were be VBD cord-010119-t1x9gknd 2417 5 randomized randomize VBN cord-010119-t1x9gknd 2417 6 to to TO cord-010119-t1x9gknd 2417 7 receive receive VB cord-010119-t1x9gknd 2417 8 either either DT cord-010119-t1x9gknd 2417 9 saline saline NN cord-010119-t1x9gknd 2417 10 , , , cord-010119-t1x9gknd 2417 11 2 2 CD cord-010119-t1x9gknd 2417 12 days day NNS cord-010119-t1x9gknd 2417 13 stored store VBN cord-010119-t1x9gknd 2417 14 or or CC cord-010119-t1x9gknd 2417 15 35 35 CD cord-010119-t1x9gknd 2417 16 days day NNS cord-010119-t1x9gknd 2417 17 stored store VBD cord-010119-t1x9gknd 2417 18 autologous autologous JJ cord-010119-t1x9gknd 2417 19 RBC RBC NNP cord-010119-t1x9gknd 2417 20 transfusion transfusion NN cord-010119-t1x9gknd 2417 21 two two CD cord-010119-t1x9gknd 2417 22 hours hour NNS cord-010119-t1x9gknd 2417 23 after after IN cord-010119-t1x9gknd 2417 24 infusion infusion NN cord-010119-t1x9gknd 2417 25 of of IN cord-010119-t1x9gknd 2417 26 lipopolysaccharide lipopolysaccharide NN cord-010119-t1x9gknd 2417 27 ( ( -LRB- cord-010119-t1x9gknd 2417 28 LPS LPS NNP cord-010119-t1x9gknd 2417 29 , , , cord-010119-t1x9gknd 2417 30 from from IN cord-010119-t1x9gknd 2417 31 E.coli E.coli NNS cord-010119-t1x9gknd 2417 32 , , , cord-010119-t1x9gknd 2417 33 2 2 CD cord-010119-t1x9gknd 2417 34 ng ng NN cord-010119-t1x9gknd 2417 35 / / SYM cord-010119-t1x9gknd 2417 36 kg kg NNP cord-010119-t1x9gknd 2417 37 ) ) -RRB- cord-010119-t1x9gknd 2417 38 . . . cord-010119-t1x9gknd 2418 1 Blood blood NN cord-010119-t1x9gknd 2418 2 was be VBD cord-010119-t1x9gknd 2418 3 sampled sample VBN cord-010119-t1x9gknd 2418 4 every every DT cord-010119-t1x9gknd 2418 5 2 2 CD cord-010119-t1x9gknd 2418 6 hours hour NNS cord-010119-t1x9gknd 2418 7 up up IN cord-010119-t1x9gknd 2418 8 to to TO cord-010119-t1x9gknd 2418 9 8 8 CD cord-010119-t1x9gknd 2418 10 hours hour NNS cord-010119-t1x9gknd 2418 11 after after IN cord-010119-t1x9gknd 2418 12 LPS LPS NNP cord-010119-t1x9gknd 2418 13 infusion infusion NN cord-010119-t1x9gknd 2418 14 . . . cord-010119-t1x9gknd 2419 1 Results/ Results/ . cord-010119-t1x9gknd 2420 1 Finding find VBG cord-010119-t1x9gknd 2421 1 : : : cord-010119-t1x9gknd 2421 2 LPS LPS NNP cord-010119-t1x9gknd 2421 3 resulted result VBD cord-010119-t1x9gknd 2421 4 in in IN cord-010119-t1x9gknd 2421 5 a a DT cord-010119-t1x9gknd 2421 6 mild mild JJ cord-010119-t1x9gknd 2421 7 increase increase NN cord-010119-t1x9gknd 2421 8 in in IN cord-010119-t1x9gknd 2421 9 thrombin thrombin JJ cord-010119-t1x9gknd 2421 10 generation generation NN cord-010119-t1x9gknd 2421 11 . . . cord-010119-t1x9gknd 2422 1 During during IN cord-010119-t1x9gknd 2422 2 storage storage NN cord-010119-t1x9gknd 2422 3 , , , cord-010119-t1x9gknd 2422 4 the the DT cord-010119-t1x9gknd 2422 5 total total JJ cord-010119-t1x9gknd 2422 6 number number NN cord-010119-t1x9gknd 2422 7 of of IN cord-010119-t1x9gknd 2422 8 microvesicles microvesicle NNS cord-010119-t1x9gknd 2422 9 increased increase VBD cord-010119-t1x9gknd 2422 10 from from IN cord-010119-t1x9gknd 2422 11 1.4e108 1.4e108 CD cord-010119-t1x9gknd 2422 12 ( ( -LRB- cord-010119-t1x9gknd 2422 13 IQR IQR NNP cord-010119-t1x9gknd 2422 14 8.3e107 8.3e107 JJ cord-010119-t1x9gknd 2422 15 - - HYPH cord-010119-t1x9gknd 2422 16 1.9e108 1.9e108 CD cord-010119-t1x9gknd 2422 17 ) ) -RRB- cord-010119-t1x9gknd 2422 18 /ml /ml . cord-010119-t1x9gknd 2423 1 in in IN cord-010119-t1x9gknd 2423 2 the the DT cord-010119-t1x9gknd 2423 3 fresh fresh JJ cord-010119-t1x9gknd 2423 4 product product NN cord-010119-t1x9gknd 2423 5 to to IN cord-010119-t1x9gknd 2423 6 1.7e110 1.7e110 NNP cord-010119-t1x9gknd 2423 7 ( ( -LRB- cord-010119-t1x9gknd 2423 8 IQR IQR NNP cord-010119-t1x9gknd 2423 9 7.9e109 7.9e109 NNP cord-010119-t1x9gknd 2423 10 - - HYPH cord-010119-t1x9gknd 2423 11 2.3e110 2.3e110 NNP cord-010119-t1x9gknd 2423 12 / / SYM cord-010119-t1x9gknd 2423 13 ml ml NN cord-010119-t1x9gknd 2423 14 ; ; : cord-010119-t1x9gknd 2423 15 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 2423 16 ) ) -RRB- cord-010119-t1x9gknd 2423 17 in in IN cord-010119-t1x9gknd 2423 18 the the DT cord-010119-t1x9gknd 2423 19 stored store VBN cord-010119-t1x9gknd 2423 20 product product NN cord-010119-t1x9gknd 2424 1 ( ( -LRB- cord-010119-t1x9gknd 2424 2 p p NN cord-010119-t1x9gknd 2424 3 < < XX cord-010119-t1x9gknd 2424 4 0.001 0.001 CD cord-010119-t1x9gknd 2424 5 ) ) -RRB- cord-010119-t1x9gknd 2424 6 , , , cord-010119-t1x9gknd 2424 7 which which WDT cord-010119-t1x9gknd 2424 8 were be VBD cord-010119-t1x9gknd 2424 9 mostly mostly RB cord-010119-t1x9gknd 2424 10 RBC RBC NNP cord-010119-t1x9gknd 2424 11 derived derive VBN cord-010119-t1x9gknd 2424 12 vesicles vesicle NNS cord-010119-t1x9gknd 2424 13 . . . cord-010119-t1x9gknd 2425 1 After after IN cord-010119-t1x9gknd 2425 2 transfusion transfusion NN cord-010119-t1x9gknd 2425 3 , , , cord-010119-t1x9gknd 2425 4 microvesicles microvesicle NNS cord-010119-t1x9gknd 2425 5 from from IN cord-010119-t1x9gknd 2425 6 stored store VBN cord-010119-t1x9gknd 2425 7 RBC RBC NNP cord-010119-t1x9gknd 2425 8 products product NNS cord-010119-t1x9gknd 2425 9 , , , cord-010119-t1x9gknd 2425 10 but but CC cord-010119-t1x9gknd 2425 11 not not RB cord-010119-t1x9gknd 2425 12 from from IN cord-010119-t1x9gknd 2425 13 fresh fresh JJ cord-010119-t1x9gknd 2425 14 products product NNS cord-010119-t1x9gknd 2425 15 , , , cord-010119-t1x9gknd 2425 16 could could MD cord-010119-t1x9gknd 2425 17 be be VB cord-010119-t1x9gknd 2425 18 detected detect VBN cord-010119-t1x9gknd 2425 19 in in IN cord-010119-t1x9gknd 2425 20 the the DT cord-010119-t1x9gknd 2425 21 circulation circulation NN cord-010119-t1x9gknd 2425 22 of of IN cord-010119-t1x9gknd 2425 23 healthy healthy JJ cord-010119-t1x9gknd 2425 24 volunteers volunteer NNS cord-010119-t1x9gknd 2425 25 and and CC cord-010119-t1x9gknd 2425 26 were be VBD cord-010119-t1x9gknd 2425 27 cleared clear VBN cord-010119-t1x9gknd 2425 28 within within IN cord-010119-t1x9gknd 2425 29 6 6 CD cord-010119-t1x9gknd 2425 30 hours hour NNS cord-010119-t1x9gknd 2425 31 . . . cord-010119-t1x9gknd 2426 1 However however RB cord-010119-t1x9gknd 2426 2 , , , cord-010119-t1x9gknd 2426 3 infusion infusion NN cord-010119-t1x9gknd 2426 4 of of IN cord-010119-t1x9gknd 2426 5 stored store VBN cord-010119-t1x9gknd 2426 6 RBC RBC NNP cord-010119-t1x9gknd 2426 7 microvesicles microvesicle NNS cord-010119-t1x9gknd 2426 8 did do VBD cord-010119-t1x9gknd 2426 9 not not RB cord-010119-t1x9gknd 2426 10 augment augment VB cord-010119-t1x9gknd 2426 11 thrombin thrombin JJ cord-010119-t1x9gknd 2426 12 generation generation NN cord-010119-t1x9gknd 2426 13 . . . cord-010119-t1x9gknd 2427 1 Levels level NNS cord-010119-t1x9gknd 2427 2 of of IN cord-010119-t1x9gknd 2427 3 D d NN cord-010119-t1x9gknd 2427 4 - - HYPH cord-010119-t1x9gknd 2427 5 dimer dimer NN cord-010119-t1x9gknd 2427 6 and and CC cord-010119-t1x9gknd 2427 7 thrombin thrombin NN cord-010119-t1x9gknd 2427 8 - - HYPH cord-010119-t1x9gknd 2427 9 antithrombin antithrombin NN cord-010119-t1x9gknd 2427 10 complex complex NN cord-010119-t1x9gknd 2427 11 were be VBD cord-010119-t1x9gknd 2427 12 also also RB cord-010119-t1x9gknd 2427 13 unaffected unaffected JJ cord-010119-t1x9gknd 2427 14 . . . cord-010119-t1x9gknd 2428 1 Conclusion conclusion NN cord-010119-t1x9gknd 2428 2 : : : cord-010119-t1x9gknd 2429 1 Transfusion transfusion NN cord-010119-t1x9gknd 2429 2 of of IN cord-010119-t1x9gknd 2429 3 autologous autologous JJ cord-010119-t1x9gknd 2429 4 RBCs rbc NNS cord-010119-t1x9gknd 2429 5 containing contain VBG cord-010119-t1x9gknd 2429 6 high high JJ cord-010119-t1x9gknd 2429 7 levels level NNS cord-010119-t1x9gknd 2429 8 of of IN cord-010119-t1x9gknd 2429 9 microvesicles microvesicle NNS cord-010119-t1x9gknd 2429 10 does do VBZ cord-010119-t1x9gknd 2429 11 not not RB cord-010119-t1x9gknd 2429 12 enhance enhance VB cord-010119-t1x9gknd 2429 13 coagulation coagulation NN cord-010119-t1x9gknd 2429 14 in in IN cord-010119-t1x9gknd 2429 15 human human JJ cord-010119-t1x9gknd 2429 16 volunteers volunteer NNS cord-010119-t1x9gknd 2429 17 with with IN cord-010119-t1x9gknd 2429 18 mild mild JJ cord-010119-t1x9gknd 2429 19 endotoxemia endotoxemia NN cord-010119-t1x9gknd 2429 20 . . . cord-010119-t1x9gknd 2430 1 Background Background NNP cord-010119-t1x9gknd 2430 2 / / SYM cord-010119-t1x9gknd 2430 3 Case Case NNP cord-010119-t1x9gknd 2430 4 Studies Studies NNPS cord-010119-t1x9gknd 2430 5 : : : cord-010119-t1x9gknd 2430 6 Transfusion transfusion NN cord-010119-t1x9gknd 2430 7 - - HYPH cord-010119-t1x9gknd 2430 8 associated associate VBN cord-010119-t1x9gknd 2430 9 circulatory circulatory JJ cord-010119-t1x9gknd 2430 10 overload overload NN cord-010119-t1x9gknd 2430 11 ( ( -LRB- cord-010119-t1x9gknd 2430 12 TACO TACO NNP cord-010119-t1x9gknd 2430 13 ) ) -RRB- cord-010119-t1x9gknd 2430 14 is be VBZ cord-010119-t1x9gknd 2430 15 characterized characterize VBN cord-010119-t1x9gknd 2430 16 by by IN cord-010119-t1x9gknd 2430 17 hydrostatic hydrostatic JJ cord-010119-t1x9gknd 2430 18 pulmonary pulmonary JJ cord-010119-t1x9gknd 2430 19 edema edema NN cord-010119-t1x9gknd 2430 20 related relate VBN cord-010119-t1x9gknd 2430 21 to to IN cord-010119-t1x9gknd 2430 22 blood blood NN cord-010119-t1x9gknd 2430 23 transfusion transfusion NN cord-010119-t1x9gknd 2430 24 . . . cord-010119-t1x9gknd 2431 1 We -PRON- PRP cord-010119-t1x9gknd 2431 2 sought seek VBD cord-010119-t1x9gknd 2431 3 to to TO cord-010119-t1x9gknd 2431 4 examine examine VB cord-010119-t1x9gknd 2431 5 contemporary contemporary JJ cord-010119-t1x9gknd 2431 6 risk risk NN cord-010119-t1x9gknd 2431 7 factors factor NNS cord-010119-t1x9gknd 2431 8 and and CC cord-010119-t1x9gknd 2431 9 outcomes outcome NNS cord-010119-t1x9gknd 2431 10 for for IN cord-010119-t1x9gknd 2431 11 TACO taco NN cord-010119-t1x9gknd 2431 12 during during IN cord-010119-t1x9gknd 2431 13 a a DT cord-010119-t1x9gknd 2431 14 period period NN cord-010119-t1x9gknd 2431 15 where where WRB cord-010119-t1x9gknd 2431 16 patient patient JJ cord-010119-t1x9gknd 2431 17 blood blood NN cord-010119-t1x9gknd 2431 18 manaement manaement NN cord-010119-t1x9gknd 2431 19 has have VBZ cord-010119-t1x9gknd 2431 20 led lead VBN cord-010119-t1x9gknd 2431 21 to to IN cord-010119-t1x9gknd 2431 22 declines decline NNS cord-010119-t1x9gknd 2431 23 in in IN cord-010119-t1x9gknd 2431 24 blood blood NN cord-010119-t1x9gknd 2431 25 utilization utilization NN cord-010119-t1x9gknd 2431 26 . . . cord-010119-t1x9gknd 2432 1 Study Study NNP cord-010119-t1x9gknd 2432 2 Design Design NNP cord-010119-t1x9gknd 2432 3 / / SYM cord-010119-t1x9gknd 2432 4 Methods method NNS cord-010119-t1x9gknd 2433 1 : : : cord-010119-t1x9gknd 2433 2 At at IN cord-010119-t1x9gknd 2433 3 four four CD cord-010119-t1x9gknd 2433 4 academic academic JJ cord-010119-t1x9gknd 2433 5 hospitals hospital NNS cord-010119-t1x9gknd 2433 6 , , , cord-010119-t1x9gknd 2433 7 cases case NNS cord-010119-t1x9gknd 2433 8 of of IN cord-010119-t1x9gknd 2433 9 TACO taco NN cord-010119-t1x9gknd 2433 10 were be VBD cord-010119-t1x9gknd 2433 11 detected detect VBN cord-010119-t1x9gknd 2433 12 by by IN cord-010119-t1x9gknd 2433 13 active active JJ cord-010119-t1x9gknd 2433 14 surveillance surveillance NN cord-010119-t1x9gknd 2433 15 of of IN cord-010119-t1x9gknd 2433 16 all all DT cord-010119-t1x9gknd 2433 17 adult adult NN cord-010119-t1x9gknd 2433 18 hospitalized hospitalize VBN cord-010119-t1x9gknd 2433 19 patients patient NNS cord-010119-t1x9gknd 2433 20 who who WP cord-010119-t1x9gknd 2433 21 received receive VBD cord-010119-t1x9gknd 2433 22 a a DT cord-010119-t1x9gknd 2433 23 blood blood NN cord-010119-t1x9gknd 2433 24 transfusion transfusion NN cord-010119-t1x9gknd 2433 25 , , , cord-010119-t1x9gknd 2433 26 and and CC cord-010119-t1x9gknd 2433 27 transfused transfused JJ cord-010119-t1x9gknd 2433 28 controls control NNS cord-010119-t1x9gknd 2433 29 were be VBD cord-010119-t1x9gknd 2433 30 matched match VBN cord-010119-t1x9gknd 2433 31 to to IN cord-010119-t1x9gknd 2433 32 cases case NNS cord-010119-t1x9gknd 2433 33 by by IN cord-010119-t1x9gknd 2433 34 transfusion transfusion NN cord-010119-t1x9gknd 2433 35 intensity intensity NN cord-010119-t1x9gknd 2433 36 . . . cord-010119-t1x9gknd 2434 1 TACO taco NN cord-010119-t1x9gknd 2434 2 incidence incidence NN cord-010119-t1x9gknd 2434 3 was be VBD cord-010119-t1x9gknd 2434 4 calculated calculate VBN cord-010119-t1x9gknd 2434 5 , , , cord-010119-t1x9gknd 2434 6 and and CC cord-010119-t1x9gknd 2434 7 clinical clinical JJ cord-010119-t1x9gknd 2434 8 characteristics characteristic NNS cord-010119-t1x9gknd 2434 9 were be VBD cord-010119-t1x9gknd 2434 10 compared compare VBN cord-010119-t1x9gknd 2434 11 with with IN cord-010119-t1x9gknd 2434 12 control control NN cord-010119-t1x9gknd 2434 13 patients patient NNS cord-010119-t1x9gknd 2434 14 . . . cord-010119-t1x9gknd 2435 1 Odds odd NNS cord-010119-t1x9gknd 2435 2 ratios ratio NNS cord-010119-t1x9gknd 2435 3 ( ( -LRB- cord-010119-t1x9gknd 2435 4 OR or NN cord-010119-t1x9gknd 2435 5 ) ) -RRB- cord-010119-t1x9gknd 2435 6 were be VBD cord-010119-t1x9gknd 2435 7 calculated calculate VBN cord-010119-t1x9gknd 2435 8 using use VBG cord-010119-t1x9gknd 2435 9 multivariable multivariable JJ cord-010119-t1x9gknd 2435 10 logistic logistic JJ cord-010119-t1x9gknd 2435 11 regression regression NN cord-010119-t1x9gknd 2435 12 . . . cord-010119-t1x9gknd 2436 1 Hospital hospital NN cord-010119-t1x9gknd 2436 2 mortality mortality NN cord-010119-t1x9gknd 2436 3 and and CC cord-010119-t1x9gknd 2436 4 length length NN cord-010119-t1x9gknd 2436 5 of of IN cord-010119-t1x9gknd 2436 6 stay stay NN cord-010119-t1x9gknd 2436 7 were be VBD cord-010119-t1x9gknd 2436 8 modeled model VBN cord-010119-t1x9gknd 2436 9 using use VBG cord-010119-t1x9gknd 2436 10 cumulative cumulative JJ cord-010119-t1x9gknd 2436 11 incidence incidence NN cord-010119-t1x9gknd 2436 12 functions function NNS cord-010119-t1x9gknd 2436 13 in in IN cord-010119-t1x9gknd 2436 14 proportional proportional JJ cord-010119-t1x9gknd 2436 15 hazards hazard NNS cord-010119-t1x9gknd 2436 16 regression regression NN cord-010119-t1x9gknd 2436 17 . . . cord-010119-t1x9gknd 2437 1 Results result NNS cord-010119-t1x9gknd 2437 2 / / SYM cord-010119-t1x9gknd 2437 3 Findings finding NNS cord-010119-t1x9gknd 2437 4 : : : cord-010119-t1x9gknd 2437 5 200 200 CD cord-010119-t1x9gknd 2437 6 cases case NNS cord-010119-t1x9gknd 2437 7 of of IN cord-010119-t1x9gknd 2437 8 TACO taco NN cord-010119-t1x9gknd 2437 9 and and CC cord-010119-t1x9gknd 2437 10 405 405 CD cord-010119-t1x9gknd 2437 11 matched match VBN cord-010119-t1x9gknd 2437 12 controls control NNS cord-010119-t1x9gknd 2437 13 were be VBD cord-010119-t1x9gknd 2437 14 enrolled enrol VBN cord-010119-t1x9gknd 2437 15 from from IN cord-010119-t1x9gknd 2437 16 20,845 20,845 CD cord-010119-t1x9gknd 2437 17 transfused transfuse VBN cord-010119-t1x9gknd 2437 18 patients patient NNS cord-010119-t1x9gknd 2437 19 who who WP cord-010119-t1x9gknd 2437 20 received receive VBD cord-010119-t1x9gknd 2437 21 128,263 128,263 CD cord-010119-t1x9gknd 2437 22 blood blood NN cord-010119-t1x9gknd 2437 23 components component NNS cord-010119-t1x9gknd 2437 24 from from IN cord-010119-t1x9gknd 2437 25 May May NNP cord-010119-t1x9gknd 2437 26 2015 2015 CD cord-010119-t1x9gknd 2437 27 until until IN cord-010119-t1x9gknd 2437 28 July July NNP cord-010119-t1x9gknd 2437 29 2016 2016 CD cord-010119-t1x9gknd 2437 30 . . . cord-010119-t1x9gknd 2438 1 TACO taco NN cord-010119-t1x9gknd 2438 2 incidence incidence NN cord-010119-t1x9gknd 2438 3 was be VBD cord-010119-t1x9gknd 2438 4 1 1 CD cord-010119-t1x9gknd 2438 5 case case NN cord-010119-t1x9gknd 2438 6 per per IN cord-010119-t1x9gknd 2438 7 100 100 CD cord-010119-t1x9gknd 2438 8 patients patient NNS cord-010119-t1x9gknd 2438 9 transfused transfuse VBN cord-010119-t1x9gknd 2438 10 . . . cord-010119-t1x9gknd 2439 1 In in IN cord-010119-t1x9gknd 2439 2 addition addition NN cord-010119-t1x9gknd 2439 3 to to IN cord-010119-t1x9gknd 2439 4 well well RB cord-010119-t1x9gknd 2439 5 described describe VBN cord-010119-t1x9gknd 2439 6 cardiac cardiac JJ cord-010119-t1x9gknd 2439 7 and and CC cord-010119-t1x9gknd 2439 8 renal renal JJ cord-010119-t1x9gknd 2439 9 comorbidities comorbiditie NNS cord-010119-t1x9gknd 2439 10 , , , cord-010119-t1x9gknd 2439 11 multivariable multivariable JJ cord-010119-t1x9gknd 2439 12 analysis analysis NN cord-010119-t1x9gknd 2439 13 identified identify VBD cord-010119-t1x9gknd 2439 14 the the DT cord-010119-t1x9gknd 2439 15 following follow VBG cord-010119-t1x9gknd 2439 16 independent independent JJ cord-010119-t1x9gknd 2439 17 predictors predictor NNS cord-010119-t1x9gknd 2439 18 of of IN cord-010119-t1x9gknd 2439 19 TACO taco NN cord-010119-t1x9gknd 2439 20 : : : cord-010119-t1x9gknd 2439 21 number number NN cord-010119-t1x9gknd 2439 22 of of IN cord-010119-t1x9gknd 2439 23 plasma plasma NN cord-010119-t1x9gknd 2439 24 units unit NNS cord-010119-t1x9gknd 2439 25 , , , cord-010119-t1x9gknd 2439 26 emergency emergency NN cord-010119-t1x9gknd 2439 27 surgery surgery NN cord-010119-t1x9gknd 2439 28 , , , cord-010119-t1x9gknd 2439 29 pre pre JJ cord-010119-t1x9gknd 2439 30 - - JJ cord-010119-t1x9gknd 2439 31 transfusion transfusion JJ cord-010119-t1x9gknd 2439 32 diuretic diuretic JJ cord-010119-t1x9gknd 2439 33 use use NN cord-010119-t1x9gknd 2439 34 , , , cord-010119-t1x9gknd 2439 35 and and CC cord-010119-t1x9gknd 2439 36 higher high JJR cord-010119-t1x9gknd 2439 37 post post JJ cord-010119-t1x9gknd 2439 38 - - JJ cord-010119-t1x9gknd 2439 39 transfusion transfusion JJ cord-010119-t1x9gknd 2439 40 hemoglobin hemoglobin NN cord-010119-t1x9gknd 2439 41 levels level NNS cord-010119-t1x9gknd 2439 42 ( ( -LRB- cord-010119-t1x9gknd 2439 43 See see VB cord-010119-t1x9gknd 2439 44 Table table NN cord-010119-t1x9gknd 2439 45 ) ) -RRB- cord-010119-t1x9gknd 2439 46 . . . cord-010119-t1x9gknd 2440 1 Compared compare VBN cord-010119-t1x9gknd 2440 2 to to IN cord-010119-t1x9gknd 2440 3 controls control NNS cord-010119-t1x9gknd 2440 4 , , , cord-010119-t1x9gknd 2440 5 TACO taco NN cord-010119-t1x9gknd 2440 6 cases case NNS cord-010119-t1x9gknd 2440 7 were be VBD cord-010119-t1x9gknd 2440 8 more more RBR cord-010119-t1x9gknd 2440 9 likely likely JJ cord-010119-t1x9gknd 2440 10 to to TO cord-010119-t1x9gknd 2440 11 require require VB cord-010119-t1x9gknd 2440 12 mechanical mechanical JJ cord-010119-t1x9gknd 2440 13 ventilation ventilation NN cord-010119-t1x9gknd 2440 14 ( ( -LRB- cord-010119-t1x9gknd 2440 15 71 71 CD cord-010119-t1x9gknd 2440 16 % % NN cord-010119-t1x9gknd 2440 17 vs. vs. IN cord-010119-t1x9gknd 2440 18 49 49 CD cord-010119-t1x9gknd 2440 19 % % NN cord-010119-t1x9gknd 2440 20 ; ; : cord-010119-t1x9gknd 2440 21 p p NN cord-010119-t1x9gknd 2440 22 < < XX cord-010119-t1x9gknd 2440 23 0.001 0.001 CD cord-010119-t1x9gknd 2440 24 ) ) -RRB- cord-010119-t1x9gknd 2440 25 , , , cord-010119-t1x9gknd 2440 26 experienced experience VBN cord-010119-t1x9gknd 2440 27 longer long RBR cord-010119-t1x9gknd 2440 28 intensive intensive JJ cord-010119-t1x9gknd 2440 29 care care NN cord-010119-t1x9gknd 2440 30 ( ( -LRB- cord-010119-t1x9gknd 2440 31 4 4 CD cord-010119-t1x9gknd 2440 32 vs. vs. CC cord-010119-t1x9gknd 2440 33 3 3 CD cord-010119-t1x9gknd 2440 34 days day NNS cord-010119-t1x9gknd 2440 35 ; ; : cord-010119-t1x9gknd 2440 36 p50.04 p50.04 NN cord-010119-t1x9gknd 2440 37 ) ) -RRB- cord-010119-t1x9gknd 2440 38 and and CC cord-010119-t1x9gknd 2440 39 hospital hospital NN cord-010119-t1x9gknd 2440 40 length length NN cord-010119-t1x9gknd 2440 41 of of IN cord-010119-t1x9gknd 2440 42 stay stay NN cord-010119-t1x9gknd 2440 43 following follow VBG cord-010119-t1x9gknd 2440 44 transfusion transfusion NN cord-010119-t1x9gknd 2440 45 ( ( -LRB- cord-010119-t1x9gknd 2440 46 10 10 CD cord-010119-t1x9gknd 2440 47 vs. vs. NN cord-010119-t1x9gknd 2440 48 7 7 CD cord-010119-t1x9gknd 2440 49 days day NNS cord-010119-t1x9gknd 2440 50 ; ; : cord-010119-t1x9gknd 2440 51 p p NN cord-010119-t1x9gknd 2440 52 < < XX cord-010119-t1x9gknd 2440 53 0.001 0.001 CD cord-010119-t1x9gknd 2440 54 ) ) -RRB- cord-010119-t1x9gknd 2440 55 , , , cord-010119-t1x9gknd 2440 56 and and CC cord-010119-t1x9gknd 2440 57 had have VBD cord-010119-t1x9gknd 2440 58 higher high JJR cord-010119-t1x9gknd 2440 59 mortality mortality NN cord-010119-t1x9gknd 2440 60 ( ( -LRB- cord-010119-t1x9gknd 2440 61 21 21 CD cord-010119-t1x9gknd 2440 62 % % NN cord-010119-t1x9gknd 2440 63 vs. vs. IN cord-010119-t1x9gknd 2440 64 11 11 CD cord-010119-t1x9gknd 2440 65 % % NN cord-010119-t1x9gknd 2440 66 ; ; : cord-010119-t1x9gknd 2440 67 p50.02 p50.02 NNP cord-010119-t1x9gknd 2440 68 ) ) -RRB- cord-010119-t1x9gknd 2440 69 . . . cord-010119-t1x9gknd 2441 1 Conclusion conclusion NN cord-010119-t1x9gknd 2441 2 : : : cord-010119-t1x9gknd 2442 1 The the DT cord-010119-t1x9gknd 2442 2 incidence incidence NN cord-010119-t1x9gknd 2442 3 of of IN cord-010119-t1x9gknd 2442 4 TACO taco NN cord-010119-t1x9gknd 2442 5 was be VBD cord-010119-t1x9gknd 2442 6 lower low JJR cord-010119-t1x9gknd 2442 7 than than IN cord-010119-t1x9gknd 2442 8 what what WP cord-010119-t1x9gknd 2442 9 has have VBZ cord-010119-t1x9gknd 2442 10 been be VBN cord-010119-t1x9gknd 2442 11 reported report VBN cord-010119-t1x9gknd 2442 12 by by IN cord-010119-t1x9gknd 2442 13 prior prior JJ cord-010119-t1x9gknd 2442 14 active active JJ cord-010119-t1x9gknd 2442 15 surveillance surveillance NN cord-010119-t1x9gknd 2442 16 studies study NNS cord-010119-t1x9gknd 2442 17 . . . cord-010119-t1x9gknd 2443 1 Despite despite IN cord-010119-t1x9gknd 2443 2 declines decline NNS cord-010119-t1x9gknd 2443 3 in in IN cord-010119-t1x9gknd 2443 4 its -PRON- PRP$ cord-010119-t1x9gknd 2443 5 incidence incidence NN cord-010119-t1x9gknd 2443 6 and and CC cord-010119-t1x9gknd 2443 7 the the DT cord-010119-t1x9gknd 2443 8 number number NN cord-010119-t1x9gknd 2443 9 of of IN cord-010119-t1x9gknd 2443 10 blood blood NN cord-010119-t1x9gknd 2443 11 components component NNS cord-010119-t1x9gknd 2443 12 transfused transfuse VBN cord-010119-t1x9gknd 2443 13 per per IN cord-010119-t1x9gknd 2443 14 case case NN cord-010119-t1x9gknd 2443 15 , , , cord-010119-t1x9gknd 2443 16 TACO TACO NNP cord-010119-t1x9gknd 2443 17 remains remain VBZ cord-010119-t1x9gknd 2443 18 a a DT cord-010119-t1x9gknd 2443 19 complication complication NN cord-010119-t1x9gknd 2443 20 of of IN cord-010119-t1x9gknd 2443 21 transfusion transfusion NN cord-010119-t1x9gknd 2443 22 with with IN cord-010119-t1x9gknd 2443 23 significant significant JJ cord-010119-t1x9gknd 2443 24 associated associate VBN cord-010119-t1x9gknd 2443 25 morbidity morbidity NN cord-010119-t1x9gknd 2443 26 and and CC cord-010119-t1x9gknd 2443 27 mortality mortality NN cord-010119-t1x9gknd 2443 28 . . . cord-010119-t1x9gknd 2444 1 In in IN cord-010119-t1x9gknd 2444 2 addition addition NN cord-010119-t1x9gknd 2444 3 to to IN cord-010119-t1x9gknd 2444 4 risk risk NN cord-010119-t1x9gknd 2444 5 factors factor NNS cord-010119-t1x9gknd 2444 6 for for IN cord-010119-t1x9gknd 2444 7 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2444 8 and and CC cord-010119-t1x9gknd 2444 9 kidney kidney NN cord-010119-t1x9gknd 2444 10 disease disease NN cord-010119-t1x9gknd 2444 11 , , , cord-010119-t1x9gknd 2444 12 plasma plasma NN cord-010119-t1x9gknd 2444 13 transfusion transfusion NN cord-010119-t1x9gknd 2444 14 and and CC cord-010119-t1x9gknd 2444 15 higher high JJR cord-010119-t1x9gknd 2444 16 post post JJ cord-010119-t1x9gknd 2444 17 - - JJ cord-010119-t1x9gknd 2444 18 transfusion transfusion JJ cord-010119-t1x9gknd 2444 19 hemoglobin hemoglobin NN cord-010119-t1x9gknd 2444 20 levels level NNS cord-010119-t1x9gknd 2444 21 were be VBD cord-010119-t1x9gknd 2444 22 associated associate VBN cord-010119-t1x9gknd 2444 23 with with IN cord-010119-t1x9gknd 2444 24 TACO taco NN cord-010119-t1x9gknd 2444 25 after after IN cord-010119-t1x9gknd 2444 26 controlling control VBG cord-010119-t1x9gknd 2444 27 for for IN cord-010119-t1x9gknd 2444 28 other other JJ cord-010119-t1x9gknd 2444 29 covariates covariate NNS cord-010119-t1x9gknd 2444 30 in in IN cord-010119-t1x9gknd 2444 31 the the DT cord-010119-t1x9gknd 2444 32 model model NN cord-010119-t1x9gknd 2444 33 . . . cord-010119-t1x9gknd 2445 1 Additional additional JJ cord-010119-t1x9gknd 2445 2 research research NN cord-010119-t1x9gknd 2445 3 is be VBZ cord-010119-t1x9gknd 2445 4 needed need VBN cord-010119-t1x9gknd 2445 5 to to TO cord-010119-t1x9gknd 2445 6 examine examine VB cord-010119-t1x9gknd 2445 7 the the DT cord-010119-t1x9gknd 2445 8 utility utility NN cord-010119-t1x9gknd 2445 9 of of IN cord-010119-t1x9gknd 2445 10 these these DT cord-010119-t1x9gknd 2445 11 risk risk NN cord-010119-t1x9gknd 2445 12 factors factor NNS cord-010119-t1x9gknd 2445 13 in in IN cord-010119-t1x9gknd 2445 14 the the DT cord-010119-t1x9gknd 2445 15 development development NN cord-010119-t1x9gknd 2445 16 of of IN cord-010119-t1x9gknd 2445 17 real real JJ cord-010119-t1x9gknd 2445 18 - - HYPH cord-010119-t1x9gknd 2445 19 time time NN cord-010119-t1x9gknd 2445 20 predictive predictive JJ cord-010119-t1x9gknd 2445 21 algorithms algorithm NNS cord-010119-t1x9gknd 2445 22 and and CC cord-010119-t1x9gknd 2445 23 the the DT cord-010119-t1x9gknd 2445 24 benefit benefit NN cord-010119-t1x9gknd 2445 25 of of IN cord-010119-t1x9gknd 2445 26 reduced reduce VBN cord-010119-t1x9gknd 2445 27 erythrocyte erythrocyte NN cord-010119-t1x9gknd 2445 28 or or CC cord-010119-t1x9gknd 2445 29 plasma plasma NN cord-010119-t1x9gknd 2445 30 exposure exposure NN cord-010119-t1x9gknd 2445 31 in in IN cord-010119-t1x9gknd 2445 32 patients patient NNS cord-010119-t1x9gknd 2445 33 at at IN cord-010119-t1x9gknd 2445 34 high high JJ cord-010119-t1x9gknd 2445 35 risk risk NN cord-010119-t1x9gknd 2445 36 for for IN cord-010119-t1x9gknd 2445 37 TACO taco NN cord-010119-t1x9gknd 2445 38 . . . cord-010119-t1x9gknd 2446 1 Background Background NNP cord-010119-t1x9gknd 2446 2 / / SYM cord-010119-t1x9gknd 2446 3 Case Case NNP cord-010119-t1x9gknd 2446 4 Studies Studies NNPS cord-010119-t1x9gknd 2446 5 : : : cord-010119-t1x9gknd 2447 1 The the DT cord-010119-t1x9gknd 2447 2 residual residual JJ cord-010119-t1x9gknd 2447 3 risk risk NN cord-010119-t1x9gknd 2447 4 of of IN cord-010119-t1x9gknd 2447 5 bacterial bacterial JJ cord-010119-t1x9gknd 2447 6 contamination contamination NN cord-010119-t1x9gknd 2447 7 of of IN cord-010119-t1x9gknd 2447 8 single single JJ cord-010119-t1x9gknd 2447 9 - - HYPH cord-010119-t1x9gknd 2447 10 donor donor NN cord-010119-t1x9gknd 2447 11 apheresis apheresis NN cord-010119-t1x9gknd 2447 12 platelets platelet NNS cord-010119-t1x9gknd 2447 13 ( ( -LRB- cord-010119-t1x9gknd 2447 14 AP AP NNP cord-010119-t1x9gknd 2447 15 ) ) -RRB- cord-010119-t1x9gknd 2447 16 was be VBD cord-010119-t1x9gknd 2447 17 recently recently RB cord-010119-t1x9gknd 2447 18 addressed address VBN cord-010119-t1x9gknd 2447 19 by by IN cord-010119-t1x9gknd 2447 20 the the DT cord-010119-t1x9gknd 2447 21 March March NNP cord-010119-t1x9gknd 2447 22 2016 2016 CD cord-010119-t1x9gknd 2447 23 FDA FDA NNP cord-010119-t1x9gknd 2447 24 draft draft NN cord-010119-t1x9gknd 2447 25 guidance guidance NN cord-010119-t1x9gknd 2447 26 to to TO cord-010119-t1x9gknd 2447 27 enhance enhance VB cord-010119-t1x9gknd 2447 28 the the DT cord-010119-t1x9gknd 2447 29 safety safety NN cord-010119-t1x9gknd 2447 30 of of IN cord-010119-t1x9gknd 2447 31 platelet platelet NN cord-010119-t1x9gknd 2447 32 transfusion transfusion NN cord-010119-t1x9gknd 2447 33 . . . cord-010119-t1x9gknd 2448 1 This this DT cord-010119-t1x9gknd 2448 2 document document NN cord-010119-t1x9gknd 2448 3 also also RB cord-010119-t1x9gknd 2448 4 describes describe VBZ cord-010119-t1x9gknd 2448 5 an an DT cord-010119-t1x9gknd 2448 6 existing exist VBG cord-010119-t1x9gknd 2448 7 pathway pathway NN cord-010119-t1x9gknd 2448 8 for for IN cord-010119-t1x9gknd 2448 9 AP AP NNP cord-010119-t1x9gknd 2448 10 outdate outdate NNP cord-010119-t1x9gknd 2448 11 extension extension NN cord-010119-t1x9gknd 2448 12 from from IN cord-010119-t1x9gknd 2448 13 5 5 CD cord-010119-t1x9gknd 2448 14 to to TO cord-010119-t1x9gknd 2448 15 7 7 CD cord-010119-t1x9gknd 2448 16 days day NNS cord-010119-t1x9gknd 2448 17 using use VBG cord-010119-t1x9gknd 2448 18 an an DT cord-010119-t1x9gknd 2448 19 FDA FDA NNP cord-010119-t1x9gknd 2448 20 cleared clear VBN cord-010119-t1x9gknd 2448 21 rapid rapid JJ cord-010119-t1x9gknd 2448 22 test test NN cord-010119-t1x9gknd 2448 23 ( ( -LRB- cord-010119-t1x9gknd 2448 24 RT RT NNP cord-010119-t1x9gknd 2448 25 ) ) -RRB- cord-010119-t1x9gknd 2448 26 . . . cord-010119-t1x9gknd 2449 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2449 2 hospital hospital NN cord-010119-t1x9gknd 2449 3 based base VBN cord-010119-t1x9gknd 2449 4 transfusion transfusion NN cord-010119-t1x9gknd 2449 5 service service NN cord-010119-t1x9gknd 2449 6 has have VBZ cord-010119-t1x9gknd 2449 7 used use VBN cord-010119-t1x9gknd 2449 8 this this DT cord-010119-t1x9gknd 2449 9 RT RT NNP cord-010119-t1x9gknd 2449 10 to to TO cord-010119-t1x9gknd 2449 11 enhance enhance VB cord-010119-t1x9gknd 2449 12 the the DT cord-010119-t1x9gknd 2449 13 safety safety NN cord-010119-t1x9gknd 2449 14 of of IN cord-010119-t1x9gknd 2449 15 AP AP NNP cord-010119-t1x9gknd 2449 16 transfusion transfusion NN cord-010119-t1x9gknd 2449 17 since since IN cord-010119-t1x9gknd 2449 18 July July NNP cord-010119-t1x9gknd 2449 19 2008 2008 CD cord-010119-t1x9gknd 2449 20 and and CC cord-010119-t1x9gknd 2449 21 to to TO cord-010119-t1x9gknd 2449 22 routinely routinely RB cord-010119-t1x9gknd 2449 23 extend extend VB cord-010119-t1x9gknd 2449 24 AP AP NNP cord-010119-t1x9gknd 2449 25 outdate outdate RB cord-010119-t1x9gknd 2449 26 to to IN cord-010119-t1x9gknd 2449 27 day day NN cord-010119-t1x9gknd 2449 28 7 7 CD cord-010119-t1x9gknd 2449 29 since since IN cord-010119-t1x9gknd 2449 30 February February NNP cord-010119-t1x9gknd 2449 31 2016 2016 CD cord-010119-t1x9gknd 2449 32 . . . cord-010119-t1x9gknd 2450 1 This this DT cord-010119-t1x9gknd 2450 2 study study NN cord-010119-t1x9gknd 2450 3 reports report VBZ cord-010119-t1x9gknd 2450 4 a a DT cord-010119-t1x9gknd 2450 5 103 103 CD cord-010119-t1x9gknd 2450 6 month month NN cord-010119-t1x9gknd 2450 7 experience experience NN cord-010119-t1x9gknd 2450 8 of of IN cord-010119-t1x9gknd 2450 9 secondary secondary JJ cord-010119-t1x9gknd 2450 10 screening screening NN cord-010119-t1x9gknd 2450 11 of of IN cord-010119-t1x9gknd 2450 12 AP AP NNP cord-010119-t1x9gknd 2450 13 using use VBG cord-010119-t1x9gknd 2450 14 a a DT cord-010119-t1x9gknd 2450 15 RT rt NN cord-010119-t1x9gknd 2450 16 . . . cord-010119-t1x9gknd 2451 1 Study Study NNP cord-010119-t1x9gknd 2451 2 Design Design NNP cord-010119-t1x9gknd 2451 3 / / SYM cord-010119-t1x9gknd 2451 4 Methods method NNS cord-010119-t1x9gknd 2451 5 : : : cord-010119-t1x9gknd 2452 1 All all DT cord-010119-t1x9gknd 2452 2 AP AP NNP cord-010119-t1x9gknd 2452 3 were be VBD cord-010119-t1x9gknd 2452 4 obtained obtain VBN cord-010119-t1x9gknd 2452 5 from from IN cord-010119-t1x9gknd 2452 6 our -PRON- PRP$ cord-010119-t1x9gknd 2452 7 hospital hospital NN cord-010119-t1x9gknd 2452 8 - - HYPH cord-010119-t1x9gknd 2452 9 based base VBN cord-010119-t1x9gknd 2452 10 donor donor NN cord-010119-t1x9gknd 2452 11 center center NN cord-010119-t1x9gknd 2452 12 or or CC cord-010119-t1x9gknd 2452 13 one one CD cord-010119-t1x9gknd 2452 14 of of IN cord-010119-t1x9gknd 2452 15 four four CD cord-010119-t1x9gknd 2452 16 external external JJ cord-010119-t1x9gknd 2452 17 suppliers supplier NNS cord-010119-t1x9gknd 2452 18 . . . cord-010119-t1x9gknd 2453 1 AP AP NNP cord-010119-t1x9gknd 2453 2 were be VBD cord-010119-t1x9gknd 2453 3 screened screen VBN cord-010119-t1x9gknd 2453 4 by by IN cord-010119-t1x9gknd 2453 5 culture culture NN cord-010119-t1x9gknd 2453 6 based base VBN cord-010119-t1x9gknd 2453 7 methods method NNS cord-010119-t1x9gknd 2453 8 post post VBP cord-010119-t1x9gknd 2453 9 - - NN cord-010119-t1x9gknd 2453 10 collection collection JJ cord-010119-t1x9gknd 2453 11 and and CC cord-010119-t1x9gknd 2453 12 prior prior RB cord-010119-t1x9gknd 2453 13 to to IN cord-010119-t1x9gknd 2453 14 entry entry NN cord-010119-t1x9gknd 2453 15 into into IN cord-010119-t1x9gknd 2453 16 our -PRON- PRP$ cord-010119-t1x9gknd 2453 17 inventory inventory NN cord-010119-t1x9gknd 2453 18 . . . cord-010119-t1x9gknd 2454 1 From from IN cord-010119-t1x9gknd 2454 2 July July NNP cord-010119-t1x9gknd 2454 3 2008-January 2008-january CD cord-010119-t1x9gknd 2454 4 2016 2016 CD cord-010119-t1x9gknd 2454 5 , , , cord-010119-t1x9gknd 2454 6 AP AP NNP cord-010119-t1x9gknd 2454 7 underwent undergo VBD cord-010119-t1x9gknd 2454 8 RT RT NNP cord-010119-t1x9gknd 2454 9 on on IN cord-010119-t1x9gknd 2454 10 day day NN cord-010119-t1x9gknd 2454 11 4 4 CD cord-010119-t1x9gknd 2454 12 . . . cord-010119-t1x9gknd 2455 1 Day day NN cord-010119-t1x9gknd 2455 2 6 6 CD cord-010119-t1x9gknd 2455 3 and and CC cord-010119-t1x9gknd 2455 4 7 7 CD cord-010119-t1x9gknd 2455 5 units unit NNS cord-010119-t1x9gknd 2455 6 were be VBD cord-010119-t1x9gknd 2455 7 transfused transfuse VBN cord-010119-t1x9gknd 2455 8 with with IN cord-010119-t1x9gknd 2455 9 physician physician NN cord-010119-t1x9gknd 2455 10 approval approval NN cord-010119-t1x9gknd 2455 11 when when WRB cord-010119-t1x9gknd 2455 12 deemed deem VBN cord-010119-t1x9gknd 2455 13 medically medically RB cord-010119-t1x9gknd 2455 14 necessary necessary JJ cord-010119-t1x9gknd 2455 15 . . . cord-010119-t1x9gknd 2456 1 Any any DT cord-010119-t1x9gknd 2456 2 units unit NNS cord-010119-t1x9gknd 2456 3 remaining remain VBG cord-010119-t1x9gknd 2456 4 in in IN cord-010119-t1x9gknd 2456 5 inventory inventory NN cord-010119-t1x9gknd 2456 6 on on IN cord-010119-t1x9gknd 2456 7 Day Day NNP cord-010119-t1x9gknd 2456 8 8 8 CD cord-010119-t1x9gknd 2456 9 had have VBD cord-010119-t1x9gknd 2456 10 a a DT cord-010119-t1x9gknd 2456 11 second second JJ cord-010119-t1x9gknd 2456 12 RT RT NNP cord-010119-t1x9gknd 2456 13 performed perform VBN cord-010119-t1x9gknd 2456 14 . . . cord-010119-t1x9gknd 2457 1 From from IN cord-010119-t1x9gknd 2457 2 February February NNP cord-010119-t1x9gknd 2457 3 2016-January 2016-january CD cord-010119-t1x9gknd 2457 4 2017 2017 CD cord-010119-t1x9gknd 2457 5 , , , cord-010119-t1x9gknd 2457 6 AP AP NNP cord-010119-t1x9gknd 2457 7 underwent undergo VBD cord-010119-t1x9gknd 2457 8 RT RT NNP cord-010119-t1x9gknd 2457 9 on on IN cord-010119-t1x9gknd 2457 10 day day NN cord-010119-t1x9gknd 2457 11 5 5 CD cord-010119-t1x9gknd 2457 12 with with IN cord-010119-t1x9gknd 2457 13 routine routine JJ cord-010119-t1x9gknd 2457 14 outdate outdate JJ cord-010119-t1x9gknd 2457 15 extension extension NN cord-010119-t1x9gknd 2457 16 to to IN cord-010119-t1x9gknd 2457 17 7 7 CD cord-010119-t1x9gknd 2457 18 days day NNS cord-010119-t1x9gknd 2457 19 by by IN cord-010119-t1x9gknd 2457 20 performing perform VBG cord-010119-t1x9gknd 2457 21 a a DT cord-010119-t1x9gknd 2457 22 second second JJ cord-010119-t1x9gknd 2457 23 RT rt NN cord-010119-t1x9gknd 2457 24 on on IN cord-010119-t1x9gknd 2457 25 day day NN cord-010119-t1x9gknd 2457 26 6 6 CD cord-010119-t1x9gknd 2457 27 and and CC cord-010119-t1x9gknd 2457 28 a a DT cord-010119-t1x9gknd 2457 29 third third JJ cord-010119-t1x9gknd 2457 30 RT RT NNP cord-010119-t1x9gknd 2457 31 on on IN cord-010119-t1x9gknd 2457 32 day day NN cord-010119-t1x9gknd 2457 33 7 7 CD cord-010119-t1x9gknd 2457 34 , , , cord-010119-t1x9gknd 2457 35 as as IN cord-010119-t1x9gknd 2457 36 per per IN cord-010119-t1x9gknd 2457 37 manufacturer manufacturer NN cord-010119-t1x9gknd 2457 38 instructions instruction NNS cord-010119-t1x9gknd 2457 39 . . . cord-010119-t1x9gknd 2458 1 Any any DT cord-010119-t1x9gknd 2458 2 positive positive JJ cord-010119-t1x9gknd 2458 3 RTs rt NNS cord-010119-t1x9gknd 2458 4 were be VBD cord-010119-t1x9gknd 2458 5 repeated repeat VBN cord-010119-t1x9gknd 2458 6 in in IN cord-010119-t1x9gknd 2458 7 triplicate triplicate NN cord-010119-t1x9gknd 2458 8 . . . cord-010119-t1x9gknd 2459 1 Repeat repeat VB cord-010119-t1x9gknd 2459 2 RT RT NNP cord-010119-t1x9gknd 2459 3 positive positive JJ cord-010119-t1x9gknd 2459 4 units unit NNS cord-010119-t1x9gknd 2459 5 were be VBD cord-010119-t1x9gknd 2459 6 quarantined quarantine VBN cord-010119-t1x9gknd 2459 7 and and CC cord-010119-t1x9gknd 2459 8 cultured culture VBN cord-010119-t1x9gknd 2459 9 to to TO cord-010119-t1x9gknd 2459 10 identify identify VB cord-010119-t1x9gknd 2459 11 true true JJ cord-010119-t1x9gknd 2459 12 positives positive NNS cord-010119-t1x9gknd 2459 13 . . . cord-010119-t1x9gknd 2460 1 False false JJ cord-010119-t1x9gknd 2460 2 positives positive NNS cord-010119-t1x9gknd 2460 3 ( ( -LRB- cord-010119-t1x9gknd 2460 4 FP FP NNP cord-010119-t1x9gknd 2460 5 ) ) -RRB- cord-010119-t1x9gknd 2460 6 were be VBD cord-010119-t1x9gknd 2460 7 defined define VBN cord-010119-t1x9gknd 2460 8 as as IN cord-010119-t1x9gknd 2460 9 repeat repeat NN cord-010119-t1x9gknd 2460 10 RT RT NNP cord-010119-t1x9gknd 2460 11 negative negative JJ cord-010119-t1x9gknd 2460 12 ( ( -LRB- cord-010119-t1x9gknd 2460 13 type type NN cord-010119-t1x9gknd 2460 14 1 1 CD cord-010119-t1x9gknd 2460 15 ) ) -RRB- cord-010119-t1x9gknd 2460 16 or or CC cord-010119-t1x9gknd 2460 17 repeat repeat VB cord-010119-t1x9gknd 2460 18 RT RT NNP cord-010119-t1x9gknd 2460 19 positive positive JJ cord-010119-t1x9gknd 2460 20 with with IN cord-010119-t1x9gknd 2460 21 negative negative JJ cord-010119-t1x9gknd 2460 22 confirmatory confirmatory JJ cord-010119-t1x9gknd 2460 23 culture culture NN cord-010119-t1x9gknd 2460 24 ( ( -LRB- cord-010119-t1x9gknd 2460 25 type type NN cord-010119-t1x9gknd 2460 26 2 2 CD cord-010119-t1x9gknd 2460 27 ) ) -RRB- cord-010119-t1x9gknd 2460 28 . . . cord-010119-t1x9gknd 2461 1 All all DT cord-010119-t1x9gknd 2461 2 RT RT NNP cord-010119-t1x9gknd 2461 3 results result NNS cord-010119-t1x9gknd 2461 4 were be VBD cord-010119-t1x9gknd 2461 5 reviewed review VBN cord-010119-t1x9gknd 2461 6 during during IN cord-010119-t1x9gknd 2461 7 both both DT cord-010119-t1x9gknd 2461 8 study study NN cord-010119-t1x9gknd 2461 9 periods period NNS cord-010119-t1x9gknd 2461 10 . . . cord-010119-t1x9gknd 2462 1 AP AP NNP cord-010119-t1x9gknd 2462 2 transfusion transfusion NN cord-010119-t1x9gknd 2462 3 and and CC cord-010119-t1x9gknd 2462 4 outdate outdate JJ cord-010119-t1x9gknd 2462 5 rates rate NNS cord-010119-t1x9gknd 2462 6 were be VBD cord-010119-t1x9gknd 2462 7 also also RB cord-010119-t1x9gknd 2462 8 summarized summarize VBN cord-010119-t1x9gknd 2462 9 . . . cord-010119-t1x9gknd 2463 1 Results result NNS cord-010119-t1x9gknd 2463 2 / / SYM cord-010119-t1x9gknd 2463 3 Findings finding NNS cord-010119-t1x9gknd 2463 4 : : : cord-010119-t1x9gknd 2464 1 Since since IN cord-010119-t1x9gknd 2464 2 July July NNP cord-010119-t1x9gknd 2464 3 2008 2008 CD cord-010119-t1x9gknd 2464 4 , , , cord-010119-t1x9gknd 2464 5 20,010 20,010 CD cord-010119-t1x9gknd 2464 6 AP AP NNP cord-010119-t1x9gknd 2464 7 were be VBD cord-010119-t1x9gknd 2464 8 entered enter VBN cord-010119-t1x9gknd 2464 9 into into IN cord-010119-t1x9gknd 2464 10 inventory inventory NN cord-010119-t1x9gknd 2464 11 . . . cord-010119-t1x9gknd 2465 1 Of of IN cord-010119-t1x9gknd 2465 2 these these DT cord-010119-t1x9gknd 2465 3 , , , cord-010119-t1x9gknd 2465 4 11,840 11,840 CD cord-010119-t1x9gknd 2465 5 ( ( -LRB- cord-010119-t1x9gknd 2465 6 59 59 CD cord-010119-t1x9gknd 2465 7 % % NN cord-010119-t1x9gknd 2465 8 ) ) -RRB- cord-010119-t1x9gknd 2465 9 were be VBD cord-010119-t1x9gknd 2465 10 transfused transfuse VBN cord-010119-t1x9gknd 2465 11 prior prior RB cord-010119-t1x9gknd 2465 12 to to IN cord-010119-t1x9gknd 2465 13 RT RT NNP cord-010119-t1x9gknd 2465 14 testing testing NN cord-010119-t1x9gknd 2465 15 . . . cord-010119-t1x9gknd 2466 1 The the DT cord-010119-t1x9gknd 2466 2 remaining remain VBG cord-010119-t1x9gknd 2466 3 8170 8170 CD cord-010119-t1x9gknd 2466 4 ( ( -LRB- cord-010119-t1x9gknd 2466 5 41 41 CD cord-010119-t1x9gknd 2466 6 % % NN cord-010119-t1x9gknd 2466 7 ) ) -RRB- cord-010119-t1x9gknd 2466 8 underwent undergo VBD cord-010119-t1x9gknd 2466 9 RT RT NNP cord-010119-t1x9gknd 2466 10 on on IN cord-010119-t1x9gknd 2466 11 day day NN cord-010119-t1x9gknd 2466 12 4 4 CD cord-010119-t1x9gknd 2466 13 or or CC cord-010119-t1x9gknd 2466 14 day day NN cord-010119-t1x9gknd 2466 15 5 5 CD cord-010119-t1x9gknd 2466 16 . . . cord-010119-t1x9gknd 2467 1 Of of IN cord-010119-t1x9gknd 2467 2 these these DT cord-010119-t1x9gknd 2467 3 43 43 CD cord-010119-t1x9gknd 2467 4 ( ( -LRB- cord-010119-t1x9gknd 2467 5 0.5 0.5 CD cord-010119-t1x9gknd 2467 6 % % NN cord-010119-t1x9gknd 2467 7 ) ) -RRB- cord-010119-t1x9gknd 2467 8 were be VBD cord-010119-t1x9gknd 2467 9 RT RT NNP cord-010119-t1x9gknd 2467 10 positive positive JJ cord-010119-t1x9gknd 2467 11 ( ( -LRB- cord-010119-t1x9gknd 2467 12 29 29 CD cord-010119-t1x9gknd 2467 13 type type NN cord-010119-t1x9gknd 2467 14 1 1 CD cord-010119-t1x9gknd 2467 15 FP FP NNP cord-010119-t1x9gknd 2467 16 , , , cord-010119-t1x9gknd 2467 17 returned return VBD cord-010119-t1x9gknd 2467 18 to to IN cord-010119-t1x9gknd 2467 19 inventory inventory NN cord-010119-t1x9gknd 2467 20 ; ; : cord-010119-t1x9gknd 2467 21 14 14 CD cord-010119-t1x9gknd 2467 22 type type NN cord-010119-t1x9gknd 2467 23 2 2 CD cord-010119-t1x9gknd 2467 24 FP FP NNP cord-010119-t1x9gknd 2467 25 , , , cord-010119-t1x9gknd 2467 26 discarded discard VBN cord-010119-t1x9gknd 2467 27 ) ) -RRB- cord-010119-t1x9gknd 2467 28 , , , cord-010119-t1x9gknd 2467 29 leaving leave VBG cord-010119-t1x9gknd 2467 30 a a DT cord-010119-t1x9gknd 2467 31 total total JJ cord-010119-t1x9gknd 2467 32 available available JJ cord-010119-t1x9gknd 2467 33 inventory inventory NN cord-010119-t1x9gknd 2467 34 of of IN cord-010119-t1x9gknd 2467 35 8156 8156 CD cord-010119-t1x9gknd 2467 36 units unit NNS cord-010119-t1x9gknd 2467 37 tested test VBN cord-010119-t1x9gknd 2467 38 by by IN cord-010119-t1x9gknd 2467 39 RT RT NNP cord-010119-t1x9gknd 2467 40 . . . cord-010119-t1x9gknd 2468 1 Of of IN cord-010119-t1x9gknd 2468 2 these these DT cord-010119-t1x9gknd 2468 3 , , , cord-010119-t1x9gknd 2468 4 5631 5631 CD cord-010119-t1x9gknd 2468 5 ( ( -LRB- cord-010119-t1x9gknd 2468 6 28 28 CD cord-010119-t1x9gknd 2468 7 % % NN cord-010119-t1x9gknd 2468 8 of of IN cord-010119-t1x9gknd 2468 9 original original JJ cord-010119-t1x9gknd 2468 10 inventory inventory NN cord-010119-t1x9gknd 2468 11 ) ) -RRB- cord-010119-t1x9gknd 2468 12 were be VBD cord-010119-t1x9gknd 2468 13 transfused transfuse VBN cord-010119-t1x9gknd 2468 14 before before IN cord-010119-t1x9gknd 2468 15 the the DT cord-010119-t1x9gknd 2468 16 end end NN cord-010119-t1x9gknd 2468 17 of of IN cord-010119-t1x9gknd 2468 18 day day NN cord-010119-t1x9gknd 2468 19 5 5 CD cord-010119-t1x9gknd 2468 20 and and CC cord-010119-t1x9gknd 2468 21 the the DT cord-010119-t1x9gknd 2468 22 remaining remain VBG cord-010119-t1x9gknd 2468 23 2525 2525 CD cord-010119-t1x9gknd 2468 24 ( ( -LRB- cord-010119-t1x9gknd 2468 25 13 13 CD cord-010119-t1x9gknd 2468 26 % % NN cord-010119-t1x9gknd 2468 27 of of IN cord-010119-t1x9gknd 2468 28 original original JJ cord-010119-t1x9gknd 2468 29 inventory inventory NN cord-010119-t1x9gknd 2468 30 ) ) -RRB- cord-010119-t1x9gknd 2468 31 reached reach VBD cord-010119-t1x9gknd 2468 32 a a DT cord-010119-t1x9gknd 2468 33 day day NN cord-010119-t1x9gknd 2468 34 5 5 CD cord-010119-t1x9gknd 2468 35 outdate outdate RB cord-010119-t1x9gknd 2468 36 . . . cord-010119-t1x9gknd 2469 1 A a DT cord-010119-t1x9gknd 2469 2 total total NN cord-010119-t1x9gknd 2469 3 of of IN cord-010119-t1x9gknd 2469 4 1561 1561 CD cord-010119-t1x9gknd 2469 5 ( ( -LRB- cord-010119-t1x9gknd 2469 6 8 8 CD cord-010119-t1x9gknd 2469 7 % % NN cord-010119-t1x9gknd 2469 8 of of IN cord-010119-t1x9gknd 2469 9 original original JJ cord-010119-t1x9gknd 2469 10 inventory inventory NN cord-010119-t1x9gknd 2469 11 ) ) -RRB- cord-010119-t1x9gknd 2469 12 were be VBD cord-010119-t1x9gknd 2469 13 transfused transfuse VBN cord-010119-t1x9gknd 2469 14 on on IN cord-010119-t1x9gknd 2469 15 day day NN cord-010119-t1x9gknd 2469 16 6 6 CD cord-010119-t1x9gknd 2469 17 or or CC cord-010119-t1x9gknd 2469 18 day day NN cord-010119-t1x9gknd 2469 19 7 7 CD cord-010119-t1x9gknd 2469 20 . . . cord-010119-t1x9gknd 2470 1 Of of IN cord-010119-t1x9gknd 2470 2 these these DT cord-010119-t1x9gknd 2470 3 , , , cord-010119-t1x9gknd 2470 4 768 768 CD cord-010119-t1x9gknd 2470 5 underwent undergo VBD cord-010119-t1x9gknd 2470 6 a a DT cord-010119-t1x9gknd 2470 7 second second JJ cord-010119-t1x9gknd 2470 8 RT rt NN cord-010119-t1x9gknd 2470 9 on on IN cord-010119-t1x9gknd 2470 10 day day NN cord-010119-t1x9gknd 2470 11 6 6 CD cord-010119-t1x9gknd 2470 12 ( ( -LRB- cord-010119-t1x9gknd 2470 13 2 2 CD cord-010119-t1x9gknd 2470 14 RT RT NNP cord-010119-t1x9gknd 2470 15 positives positive NNS cord-010119-t1x9gknd 2470 16 ; ; : cord-010119-t1x9gknd 2470 17 1 1 CD cord-010119-t1x9gknd 2470 18 FP FP NNP cord-010119-t1x9gknd 2470 19 type type NN cord-010119-t1x9gknd 2470 20 one one NN cord-010119-t1x9gknd 2470 21 and and CC cord-010119-t1x9gknd 2470 22 1 1 CD cord-010119-t1x9gknd 2470 23 FP FP NNP cord-010119-t1x9gknd 2470 24 type type NN cord-010119-t1x9gknd 2470 25 2 2 CD cord-010119-t1x9gknd 2470 26 ) ) -RRB- cord-010119-t1x9gknd 2470 27 and and CC cord-010119-t1x9gknd 2470 28 233 233 CD cord-010119-t1x9gknd 2470 29 underwent undergo VBD cord-010119-t1x9gknd 2470 30 a a DT cord-010119-t1x9gknd 2470 31 third third JJ cord-010119-t1x9gknd 2470 32 RT RT NNP cord-010119-t1x9gknd 2470 33 on on IN cord-010119-t1x9gknd 2470 34 day day NN cord-010119-t1x9gknd 2470 35 7 7 CD cord-010119-t1x9gknd 2470 36 ( ( -LRB- cord-010119-t1x9gknd 2470 37 no no DT cord-010119-t1x9gknd 2470 38 positive positive JJ cord-010119-t1x9gknd 2470 39 results result NNS cord-010119-t1x9gknd 2470 40 ) ) -RRB- cord-010119-t1x9gknd 2470 41 . . . cord-010119-t1x9gknd 2471 1 A a DT cord-010119-t1x9gknd 2471 2 total total NN cord-010119-t1x9gknd 2471 3 of of IN cord-010119-t1x9gknd 2471 4 964 964 CD cord-010119-t1x9gknd 2471 5 ( ( -LRB- cord-010119-t1x9gknd 2471 6 5 5 CD cord-010119-t1x9gknd 2471 7 % % NN cord-010119-t1x9gknd 2471 8 of of IN cord-010119-t1x9gknd 2471 9 original original JJ cord-010119-t1x9gknd 2471 10 inventory inventory NN cord-010119-t1x9gknd 2471 11 ) ) -RRB- cord-010119-t1x9gknd 2471 12 outdated outdate VBN cord-010119-t1x9gknd 2471 13 on on IN cord-010119-t1x9gknd 2471 14 day day NN cord-010119-t1x9gknd 2471 15 7 7 CD cord-010119-t1x9gknd 2471 16 . . . cord-010119-t1x9gknd 2472 1 Of of IN cord-010119-t1x9gknd 2472 2 these these DT cord-010119-t1x9gknd 2472 3 , , , cord-010119-t1x9gknd 2472 4 754 754 CD cord-010119-t1x9gknd 2472 5 underwent undergo VBD cord-010119-t1x9gknd 2472 6 a a DT cord-010119-t1x9gknd 2472 7 second second JJ cord-010119-t1x9gknd 2472 8 RT rt NN cord-010119-t1x9gknd 2472 9 on on IN cord-010119-t1x9gknd 2472 10 day day NN cord-010119-t1x9gknd 2472 11 8 8 CD cord-010119-t1x9gknd 2472 12 ( ( -LRB- cord-010119-t1x9gknd 2472 13 no no DT cord-010119-t1x9gknd 2472 14 positive positive JJ cord-010119-t1x9gknd 2472 15 results result NNS cord-010119-t1x9gknd 2472 16 ) ) -RRB- cord-010119-t1x9gknd 2472 17 . . . cord-010119-t1x9gknd 2473 1 Conclusion conclusion NN cord-010119-t1x9gknd 2473 2 : : : cord-010119-t1x9gknd 2474 1 To to IN cord-010119-t1x9gknd 2474 2 date date NN cord-010119-t1x9gknd 2474 3 we -PRON- PRP cord-010119-t1x9gknd 2474 4 have have VBP cord-010119-t1x9gknd 2474 5 performed perform VBN cord-010119-t1x9gknd 2474 6 9925 9925 CD cord-010119-t1x9gknd 2474 7 RTs rt NNS cord-010119-t1x9gknd 2474 8 on on IN cord-010119-t1x9gknd 2474 9 AP AP NNP cord-010119-t1x9gknd 2474 10 at at IN cord-010119-t1x9gknd 2474 11 our -PRON- PRP$ cord-010119-t1x9gknd 2474 12 hospital hospital NN cord-010119-t1x9gknd 2474 13 . . . cord-010119-t1x9gknd 2475 1 No no DT cord-010119-t1x9gknd 2475 2 true true JJ cord-010119-t1x9gknd 2475 3 positives positive NNS cord-010119-t1x9gknd 2475 4 have have VBP cord-010119-t1x9gknd 2475 5 been be VBN cord-010119-t1x9gknd 2475 6 identified identify VBN cord-010119-t1x9gknd 2475 7 . . . cord-010119-t1x9gknd 2476 1 Use Use NNP cord-010119-t1x9gknd 2476 2 of of IN cord-010119-t1x9gknd 2476 3 RT RT NNP cord-010119-t1x9gknd 2476 4 over over IN cord-010119-t1x9gknd 2476 5 the the DT cord-010119-t1x9gknd 2476 6 study study NN cord-010119-t1x9gknd 2476 7 period period NN cord-010119-t1x9gknd 2476 8 decreased decrease VBD cord-010119-t1x9gknd 2476 9 our -PRON- PRP$ cord-010119-t1x9gknd 2476 10 outdate outdate JJ cord-010119-t1x9gknd 2476 11 rate rate NN cord-010119-t1x9gknd 2476 12 from from IN cord-010119-t1x9gknd 2476 13 a a DT cord-010119-t1x9gknd 2476 14 predicted predict VBN cord-010119-t1x9gknd 2476 15 13 13 CD cord-010119-t1x9gknd 2476 16 % % NN cord-010119-t1x9gknd 2476 17 to to IN cord-010119-t1x9gknd 2476 18 only only RB cord-010119-t1x9gknd 2476 19 5 5 CD cord-010119-t1x9gknd 2476 20 % % NN cord-010119-t1x9gknd 2476 21 . . . cord-010119-t1x9gknd 2477 1 A a DT cord-010119-t1x9gknd 2477 2 total total NN cord-010119-t1x9gknd 2477 3 of of IN cord-010119-t1x9gknd 2477 4 1522 1522 CD cord-010119-t1x9gknd 2477 5 AP AP NNP cord-010119-t1x9gknd 2477 6 have have VBP cord-010119-t1x9gknd 2477 7 been be VBN cord-010119-t1x9gknd 2477 8 tested test VBN cord-010119-t1x9gknd 2477 9 twice twice RB cord-010119-t1x9gknd 2477 10 by by IN cord-010119-t1x9gknd 2477 11 RT RT NNP cord-010119-t1x9gknd 2477 12 ( ( -LRB- cord-010119-t1x9gknd 2477 13 768 768 CD cord-010119-t1x9gknd 2477 14 on on IN cord-010119-t1x9gknd 2477 15 day day NN cord-010119-t1x9gknd 2477 16 5 5 CD cord-010119-t1x9gknd 2477 17 and and CC cord-010119-t1x9gknd 2477 18 6 6 CD cord-010119-t1x9gknd 2477 19 ; ; : cord-010119-t1x9gknd 2477 20 754 754 CD cord-010119-t1x9gknd 2477 21 on on IN cord-010119-t1x9gknd 2477 22 day day NN cord-010119-t1x9gknd 2477 23 4 4 CD cord-010119-t1x9gknd 2477 24 and and CC cord-010119-t1x9gknd 2477 25 8) 8) NN cord-010119-t1x9gknd 2477 26 with with IN cord-010119-t1x9gknd 2477 27 2 2 CD cord-010119-t1x9gknd 2477 28 ( ( -LRB- cord-010119-t1x9gknd 2477 29 0.1 0.1 CD cord-010119-t1x9gknd 2477 30 % % NN cord-010119-t1x9gknd 2477 31 ) ) -RRB- cord-010119-t1x9gknd 2477 32 positive positive JJ cord-010119-t1x9gknd 2477 33 results result NNS cord-010119-t1x9gknd 2477 34 , , , cord-010119-t1x9gknd 2477 35 both both DT cord-010119-t1x9gknd 2477 36 of of IN cord-010119-t1x9gknd 2477 37 which which WDT cord-010119-t1x9gknd 2477 38 were be VBD cord-010119-t1x9gknd 2477 39 deemed deem VBN cord-010119-t1x9gknd 2477 40 FP FP NNP cord-010119-t1x9gknd 2477 41 by by IN cord-010119-t1x9gknd 2477 42 repeat repeat NN cord-010119-t1x9gknd 2477 43 testing testing NN cord-010119-t1x9gknd 2477 44 or or CC cord-010119-t1x9gknd 2477 45 culture culture NN cord-010119-t1x9gknd 2477 46 . . . cord-010119-t1x9gknd 2478 1 A a DT cord-010119-t1x9gknd 2478 2 total total NN cord-010119-t1x9gknd 2478 3 of of IN cord-010119-t1x9gknd 2478 4 233 233 CD cord-010119-t1x9gknd 2478 5 units unit NNS cord-010119-t1x9gknd 2478 6 have have VBP cord-010119-t1x9gknd 2478 7 been be VBN cord-010119-t1x9gknd 2478 8 tested test VBN cord-010119-t1x9gknd 2478 9 3 3 CD cord-010119-t1x9gknd 2478 10 times time NNS cord-010119-t1x9gknd 2478 11 ( ( -LRB- cord-010119-t1x9gknd 2478 12 day day NN cord-010119-t1x9gknd 2478 13 5 5 CD cord-010119-t1x9gknd 2478 14 , , , cord-010119-t1x9gknd 2478 15 day day NN cord-010119-t1x9gknd 2478 16 6 6 CD cord-010119-t1x9gknd 2478 17 and and CC cord-010119-t1x9gknd 2478 18 day day NN cord-010119-t1x9gknd 2478 19 7 7 CD cord-010119-t1x9gknd 2478 20 ) ) -RRB- cord-010119-t1x9gknd 2478 21 with with IN cord-010119-t1x9gknd 2478 22 no no DT cord-010119-t1x9gknd 2478 23 additional additional JJ cord-010119-t1x9gknd 2478 24 positives positive NNS cord-010119-t1x9gknd 2478 25 identified identify VBN cord-010119-t1x9gknd 2478 26 . . . cord-010119-t1x9gknd 2479 1 We -PRON- PRP cord-010119-t1x9gknd 2479 2 have have VBP cord-010119-t1x9gknd 2479 3 not not RB cord-010119-t1x9gknd 2479 4 yet yet RB cord-010119-t1x9gknd 2479 5 identified identify VBN cord-010119-t1x9gknd 2479 6 any any DT cord-010119-t1x9gknd 2479 7 units unit NNS cord-010119-t1x9gknd 2479 8 with with IN cord-010119-t1x9gknd 2479 9 an an DT cord-010119-t1x9gknd 2479 10 initial initial JJ cord-010119-t1x9gknd 2479 11 negative negative JJ cord-010119-t1x9gknd 2479 12 RT rt NN cord-010119-t1x9gknd 2479 13 result result NN cord-010119-t1x9gknd 2479 14 that that WDT cord-010119-t1x9gknd 2479 15 subsequently subsequently RB cord-010119-t1x9gknd 2479 16 converted convert VBD cord-010119-t1x9gknd 2479 17 to to IN cord-010119-t1x9gknd 2479 18 a a DT cord-010119-t1x9gknd 2479 19 true true JJ cord-010119-t1x9gknd 2479 20 positive positive JJ cord-010119-t1x9gknd 2479 21 . . . cord-010119-t1x9gknd 2480 1 There there EX cord-010119-t1x9gknd 2480 2 is be VBZ cord-010119-t1x9gknd 2480 3 a a DT cord-010119-t1x9gknd 2480 4 low low JJ cord-010119-t1x9gknd 2480 5 FP FP NNP cord-010119-t1x9gknd 2480 6 rate rate NN cord-010119-t1x9gknd 2480 7 which which WDT cord-010119-t1x9gknd 2480 8 should should MD cord-010119-t1x9gknd 2480 9 also also RB cord-010119-t1x9gknd 2480 10 be be VB cord-010119-t1x9gknd 2480 11 expected expect VBN cord-010119-t1x9gknd 2480 12 when when WRB cord-010119-t1x9gknd 2480 13 performing perform VBG cord-010119-t1x9gknd 2480 14 repeat repeat NN cord-010119-t1x9gknd 2480 15 testing testing NN cord-010119-t1x9gknd 2480 16 on on IN cord-010119-t1x9gknd 2480 17 the the DT cord-010119-t1x9gknd 2480 18 same same JJ cord-010119-t1x9gknd 2480 19 unit unit NN cord-010119-t1x9gknd 2480 20 . . . cord-010119-t1x9gknd 2481 1 These these DT cord-010119-t1x9gknd 2481 2 data datum NNS cord-010119-t1x9gknd 2481 3 suggest suggest VBP cord-010119-t1x9gknd 2481 4 that that IN cord-010119-t1x9gknd 2481 5 the the DT cord-010119-t1x9gknd 2481 6 yield yield NN cord-010119-t1x9gknd 2481 7 for for IN cord-010119-t1x9gknd 2481 8 repeating repeat VBG cord-010119-t1x9gknd 2481 9 the the DT cord-010119-t1x9gknd 2481 10 RT RT NNP cord-010119-t1x9gknd 2481 11 every every DT cord-010119-t1x9gknd 2481 12 24 24 CD cord-010119-t1x9gknd 2481 13 hours hour NNS cord-010119-t1x9gknd 2481 14 , , , cord-010119-t1x9gknd 2481 15 as as IN cord-010119-t1x9gknd 2481 16 currently currently RB cord-010119-t1x9gknd 2481 17 specified specify VBN cord-010119-t1x9gknd 2481 18 by by IN cord-010119-t1x9gknd 2481 19 the the DT cord-010119-t1x9gknd 2481 20 manufacturer manufacturer NN cord-010119-t1x9gknd 2481 21 instructions instruction NNS cord-010119-t1x9gknd 2481 22 , , , cord-010119-t1x9gknd 2481 23 is be VBZ cord-010119-t1x9gknd 2481 24 quite quite RB cord-010119-t1x9gknd 2481 25 low low JJ cord-010119-t1x9gknd 2481 26 . . . cord-010119-t1x9gknd 2482 1 Additional additional JJ cord-010119-t1x9gknd 2482 2 studies study NNS cord-010119-t1x9gknd 2482 3 are be VBP cord-010119-t1x9gknd 2482 4 needed need VBN cord-010119-t1x9gknd 2482 5 to to TO cord-010119-t1x9gknd 2482 6 clarify clarify VB cord-010119-t1x9gknd 2482 7 how how WRB cord-010119-t1x9gknd 2482 8 RT RT NNP cord-010119-t1x9gknd 2482 9 can can MD cord-010119-t1x9gknd 2482 10 optimally optimally RB cord-010119-t1x9gknd 2482 11 be be VB cord-010119-t1x9gknd 2482 12 used use VBN cord-010119-t1x9gknd 2482 13 to to TO cord-010119-t1x9gknd 2482 14 enhance enhance VB cord-010119-t1x9gknd 2482 15 detection detection NN cord-010119-t1x9gknd 2482 16 of of IN cord-010119-t1x9gknd 2482 17 AP AP NNP cord-010119-t1x9gknd 2482 18 bacterial bacterial JJ cord-010119-t1x9gknd 2482 19 contamination contamination NN cord-010119-t1x9gknd 2482 20 . . . cord-010119-t1x9gknd 2483 1 Survival survival NN cord-010119-t1x9gknd 2483 2 of of IN cord-010119-t1x9gknd 2483 3 Trypanosoma Trypanosoma NNP cord-010119-t1x9gknd 2483 4 Cruzi Cruzi NNP cord-010119-t1x9gknd 2483 5 in in IN cord-010119-t1x9gknd 2483 6 Human Human NNP cord-010119-t1x9gknd 2483 7 Blood Blood NNP cord-010119-t1x9gknd 2483 8 Components Components NNP cord-010119-t1x9gknd 2483 9 Laura Laura NNP cord-010119-t1x9gknd 2483 10 Tonnetti Tonnetti NNP cord-010119-t1x9gknd 2484 1 * * NFP cord-010119-t1x9gknd 2484 2 , , , cord-010119-t1x9gknd 2484 3 Aaron Aaron NNP cord-010119-t1x9gknd 2484 4 Thorp Thorp NNP cord-010119-t1x9gknd 2484 5 and and CC cord-010119-t1x9gknd 2484 6 Susan Susan NNP cord-010119-t1x9gknd 2484 7 L L NNP cord-010119-t1x9gknd 2484 8 Stramer Stramer NNP cord-010119-t1x9gknd 2484 9 . . . cord-010119-t1x9gknd 2485 1 American American NNP cord-010119-t1x9gknd 2485 2 Red Red NNP cord-010119-t1x9gknd 2485 3 Cross Cross NNP cord-010119-t1x9gknd 2485 4 Background Background NNP cord-010119-t1x9gknd 2485 5 / / SYM cord-010119-t1x9gknd 2485 6 Case Case NNP cord-010119-t1x9gknd 2485 7 Studies Studies NNPS cord-010119-t1x9gknd 2485 8 : : : cord-010119-t1x9gknd 2486 1 Trypanosoma Trypanosoma NNP cord-010119-t1x9gknd 2486 2 cruzi cruzi NNP cord-010119-t1x9gknd 2486 3 , , , cord-010119-t1x9gknd 2486 4 the the DT cord-010119-t1x9gknd 2486 5 agent agent NN cord-010119-t1x9gknd 2486 6 of of IN cord-010119-t1x9gknd 2486 7 Chagas Chagas NNP cord-010119-t1x9gknd 2486 8 disease disease NN cord-010119-t1x9gknd 2486 9 , , , cord-010119-t1x9gknd 2486 10 is be VBZ cord-010119-t1x9gknd 2486 11 associated associate VBN cord-010119-t1x9gknd 2486 12 with with IN cord-010119-t1x9gknd 2486 13 8 8 CD cord-010119-t1x9gknd 2486 14 to to TO cord-010119-t1x9gknd 2486 15 10 10 CD cord-010119-t1x9gknd 2486 16 million million CD cord-010119-t1x9gknd 2486 17 infections infection NNS cord-010119-t1x9gknd 2486 18 worldwide worldwide RB cord-010119-t1x9gknd 2486 19 , , , cord-010119-t1x9gknd 2486 20 mostly mostly RB cord-010119-t1x9gknd 2486 21 in in IN cord-010119-t1x9gknd 2486 22 Latin Latin NNP cord-010119-t1x9gknd 2486 23 America America NNP cord-010119-t1x9gknd 2486 24 . . . cord-010119-t1x9gknd 2487 1 Despite despite IN cord-010119-t1x9gknd 2487 2 the the DT cord-010119-t1x9gknd 2487 3 extensive extensive JJ cord-010119-t1x9gknd 2487 4 immigration immigration NN cord-010119-t1x9gknd 2487 5 from from IN cord-010119-t1x9gknd 2487 6 endemic endemic JJ cord-010119-t1x9gknd 2487 7 areas area NNS cord-010119-t1x9gknd 2487 8 , , , cord-010119-t1x9gknd 2487 9 only only RB cord-010119-t1x9gknd 2487 10 5 5 CD cord-010119-t1x9gknd 2487 11 cases case NNS cord-010119-t1x9gknd 2487 12 of of IN cord-010119-t1x9gknd 2487 13 transfusion transfusion NN cord-010119-t1x9gknd 2487 14 - - HYPH cord-010119-t1x9gknd 2487 15 transmission transmission NN cord-010119-t1x9gknd 2487 16 ( ( -LRB- cord-010119-t1x9gknd 2487 17 TT TT NNP cord-010119-t1x9gknd 2487 18 ) ) -RRB- cord-010119-t1x9gknd 2487 19 T. T. NNP cord-010119-t1x9gknd 2487 20 cruzi cruzi NNP cord-010119-t1x9gknd 2487 21 have have VBP cord-010119-t1x9gknd 2487 22 been be VBN cord-010119-t1x9gknd 2487 23 reported report VBN cord-010119-t1x9gknd 2487 24 in in IN cord-010119-t1x9gknd 2487 25 the the DT cord-010119-t1x9gknd 2487 26 US US NNP cord-010119-t1x9gknd 2487 27 , , , cord-010119-t1x9gknd 2487 28 before before IN cord-010119-t1x9gknd 2487 29 blood blood NN cord-010119-t1x9gknd 2487 30 donor donor NN cord-010119-t1x9gknd 2487 31 screening screening NN cord-010119-t1x9gknd 2487 32 was be VBD cord-010119-t1x9gknd 2487 33 implemented implement VBN cord-010119-t1x9gknd 2487 34 in in IN cord-010119-t1x9gknd 2487 35 2007 2007 CD cord-010119-t1x9gknd 2487 36 . . . cord-010119-t1x9gknd 2488 1 Contributing contribute VBG cord-010119-t1x9gknd 2488 2 factors factor NNS cord-010119-t1x9gknd 2488 3 to to IN cord-010119-t1x9gknd 2488 4 the the DT cord-010119-t1x9gknd 2488 5 low low JJ cord-010119-t1x9gknd 2488 6 number number NN cord-010119-t1x9gknd 2488 7 of of IN cord-010119-t1x9gknd 2488 8 TT TT NNP cord-010119-t1x9gknd 2488 9 cases case NNS cord-010119-t1x9gknd 2488 10 are be VBP cord-010119-t1x9gknd 2488 11 a a DT cord-010119-t1x9gknd 2488 12 possible possible JJ cord-010119-t1x9gknd 2488 13 association association NN cord-010119-t1x9gknd 2488 14 between between IN cord-010119-t1x9gknd 2488 15 parasite parasite NN cord-010119-t1x9gknd 2488 16 lineage lineage NN cord-010119-t1x9gknd 2488 17 and and CC cord-010119-t1x9gknd 2488 18 TT TT NNP cord-010119-t1x9gknd 2488 19 , , , cord-010119-t1x9gknd 2488 20 and and CC cord-010119-t1x9gknd 2488 21 high high JJ cord-010119-t1x9gknd 2488 22 numbers number NNS cord-010119-t1x9gknd 2488 23 of of IN cord-010119-t1x9gknd 2488 24 unreported unreported JJ cord-010119-t1x9gknd 2488 25 cases case NNS cord-010119-t1x9gknd 2488 26 . . . cord-010119-t1x9gknd 2489 1 Platelets platelet NNS cord-010119-t1x9gknd 2489 2 are be VBP cord-010119-t1x9gknd 2489 3 almost almost RB cord-010119-t1x9gknd 2489 4 exclusively exclusively RB cord-010119-t1x9gknd 2489 5 involved involve VBN cord-010119-t1x9gknd 2489 6 in in IN cord-010119-t1x9gknd 2489 7 T. T. NNP cord-010119-t1x9gknd 2489 8 cruzi cruzi NN cord-010119-t1x9gknd 2489 9 TT TT NNP cord-010119-t1x9gknd 2489 10 cases case NNS cord-010119-t1x9gknd 2489 11 ; ; : cord-010119-t1x9gknd 2489 12 however however RB cord-010119-t1x9gknd 2489 13 , , , cord-010119-t1x9gknd 2489 14 during during IN cord-010119-t1x9gknd 2489 15 preparation preparation NN cord-010119-t1x9gknd 2489 16 of of IN cord-010119-t1x9gknd 2489 17 components component NNS cord-010119-t1x9gknd 2489 18 a a DT cord-010119-t1x9gknd 2489 19 large large JJ cord-010119-t1x9gknd 2489 20 fraction fraction NN cord-010119-t1x9gknd 2489 21 of of IN cord-010119-t1x9gknd 2489 22 the the DT cord-010119-t1x9gknd 2489 23 parasites parasite NNS cord-010119-t1x9gknd 2489 24 can can MD cord-010119-t1x9gknd 2489 25 be be VB cord-010119-t1x9gknd 2489 26 found find VBN cord-010119-t1x9gknd 2489 27 in in IN cord-010119-t1x9gknd 2489 28 red red JJ cord-010119-t1x9gknd 2489 29 blood blood NN cord-010119-t1x9gknd 2489 30 cells cell NNS cord-010119-t1x9gknd 2489 31 ( ( -LRB- cord-010119-t1x9gknd 2489 32 RBCs rbc NNS cord-010119-t1x9gknd 2489 33 ) ) -RRB- cord-010119-t1x9gknd 2489 34 . . . cord-010119-t1x9gknd 2490 1 We -PRON- PRP cord-010119-t1x9gknd 2490 2 investigated investigate VBD cord-010119-t1x9gknd 2490 3 if if IN cord-010119-t1x9gknd 2490 4 blood blood NN cord-010119-t1x9gknd 2490 5 component component NN cord-010119-t1x9gknd 2490 6 preparation preparation NN cord-010119-t1x9gknd 2490 7 and and CC cord-010119-t1x9gknd 2490 8 storage storage NN cord-010119-t1x9gknd 2490 9 time time NN cord-010119-t1x9gknd 2490 10 affect affect VBP cord-010119-t1x9gknd 2490 11 the the DT cord-010119-t1x9gknd 2490 12 survival survival NN cord-010119-t1x9gknd 2490 13 of of IN cord-010119-t1x9gknd 2490 14 the the DT cord-010119-t1x9gknd 2490 15 parasite parasite NN cord-010119-t1x9gknd 2490 16 and and CC cord-010119-t1x9gknd 2490 17 thus thus RB cord-010119-t1x9gknd 2490 18 play play VB cord-010119-t1x9gknd 2490 19 a a DT cord-010119-t1x9gknd 2490 20 role role NN cord-010119-t1x9gknd 2490 21 in in IN cord-010119-t1x9gknd 2490 22 TT TT NNP cord-010119-t1x9gknd 2490 23 of of IN cord-010119-t1x9gknd 2490 24 T. T. NNP cord-010119-t1x9gknd 2490 25 cruzi cruzi NNP cord-010119-t1x9gknd 2490 26 . . . cord-010119-t1x9gknd 2491 1 Study Study NNP cord-010119-t1x9gknd 2491 2 Design Design NNP cord-010119-t1x9gknd 2491 3 / / SYM cord-010119-t1x9gknd 2491 4 Method method NN cord-010119-t1x9gknd 2491 5 : : : cord-010119-t1x9gknd 2492 1 Whole whole JJ cord-010119-t1x9gknd 2492 2 blood blood NN cord-010119-t1x9gknd 2492 3 ( ( -LRB- cord-010119-t1x9gknd 2492 4 WB WB NNP cord-010119-t1x9gknd 2492 5 ) ) -RRB- cord-010119-t1x9gknd 2492 6 units unit NNS cord-010119-t1x9gknd 2492 7 were be VBD cord-010119-t1x9gknd 2492 8 spiked spike VBN cord-010119-t1x9gknd 2492 9 with with IN cord-010119-t1x9gknd 2492 10 T. T. NNP cord-010119-t1x9gknd 2492 11 cruzi cruzi NNP cord-010119-t1x9gknd 2492 12 trypomastigotes trypomastigotes NNP cord-010119-t1x9gknd 2492 13 to to IN cord-010119-t1x9gknd 2492 14 a a DT cord-010119-t1x9gknd 2492 15 final final JJ cord-010119-t1x9gknd 2492 16 concentration concentration NN cord-010119-t1x9gknd 2492 17 between between IN cord-010119-t1x9gknd 2492 18 10 10 CD cord-010119-t1x9gknd 2492 19 - - SYM cord-010119-t1x9gknd 2492 20 10,000 10,000 CD cord-010119-t1x9gknd 2492 21 parasites parasite NNS cord-010119-t1x9gknd 2492 22 / / SYM cord-010119-t1x9gknd 2492 23 mL. mL. NNS cord-010119-t1x9gknd 2492 24 Each each DT cord-010119-t1x9gknd 2492 25 parasite parasite NN cord-010119-t1x9gknd 2492 26 concentration concentration NN cord-010119-t1x9gknd 2492 27 in in IN cord-010119-t1x9gknd 2492 28 WB WB NNP cord-010119-t1x9gknd 2492 29 was be VBD cord-010119-t1x9gknd 2492 30 tested test VBN cord-010119-t1x9gknd 2492 31 x2 x2 NNP cord-010119-t1x9gknd 2492 32 . . . cord-010119-t1x9gknd 2493 1 An an DT cord-010119-t1x9gknd 2493 2 aliquot aliquot NN cord-010119-t1x9gknd 2493 3 of of IN cord-010119-t1x9gknd 2493 4 contaminated contaminated JJ cord-010119-t1x9gknd 2493 5 WB WB NNP cord-010119-t1x9gknd 2493 6 was be VBD cord-010119-t1x9gknd 2493 7 used use VBN cord-010119-t1x9gknd 2493 8 to to TO cord-010119-t1x9gknd 2493 9 prepare prepare VB cord-010119-t1x9gknd 2493 10 hemocultures hemoculture NNS cord-010119-t1x9gknd 2493 11 to to TO cord-010119-t1x9gknd 2493 12 detect detect VB cord-010119-t1x9gknd 2493 13 live live JJ cord-010119-t1x9gknd 2493 14 parasites parasite NNS cord-010119-t1x9gknd 2493 15 before before IN cord-010119-t1x9gknd 2493 16 preparation preparation NN cord-010119-t1x9gknd 2493 17 of of IN cord-010119-t1x9gknd 2493 18 components component NNS cord-010119-t1x9gknd 2493 19 . . . cord-010119-t1x9gknd 2494 1 RBCs rbc NNS cord-010119-t1x9gknd 2494 2 were be VBD cord-010119-t1x9gknd 2494 3 separated separate VBN cord-010119-t1x9gknd 2494 4 and and CC cord-010119-t1x9gknd 2494 5 half half NN cord-010119-t1x9gknd 2494 6 of of IN cord-010119-t1x9gknd 2494 7 the the DT cord-010119-t1x9gknd 2494 8 components component NNS cord-010119-t1x9gknd 2494 9 leukoreduced leukoreduce VBN cord-010119-t1x9gknd 2494 10 ( ( -LRB- cord-010119-t1x9gknd 2494 11 LR LR NNP cord-010119-t1x9gknd 2494 12 ) ) -RRB- cord-010119-t1x9gknd 2494 13 by by IN cord-010119-t1x9gknd 2494 14 filtration filtration NN cord-010119-t1x9gknd 2494 15 . . . cord-010119-t1x9gknd 2495 1 Platelets platelet NNS cord-010119-t1x9gknd 2495 2 and and CC cord-010119-t1x9gknd 2495 3 plasma plasma NN cord-010119-t1x9gknd 2495 4 were be VBD cord-010119-t1x9gknd 2495 5 separated separate VBN cord-010119-t1x9gknd 2495 6 , , , cord-010119-t1x9gknd 2495 7 along along IN cord-010119-t1x9gknd 2495 8 with with IN cord-010119-t1x9gknd 2495 9 one one CD cord-010119-t1x9gknd 2495 10 aliquot aliquot NN cord-010119-t1x9gknd 2495 11 of of IN cord-010119-t1x9gknd 2495 12 plasma plasma NN cord-010119-t1x9gknd 2495 13 collected collect VBN cord-010119-t1x9gknd 2495 14 before before IN cord-010119-t1x9gknd 2495 15 LR LR NNP cord-010119-t1x9gknd 2495 16 . . . cord-010119-t1x9gknd 2496 1 RBCs rbc NNS cord-010119-t1x9gknd 2496 2 were be VBD cord-010119-t1x9gknd 2496 3 stored store VBN cord-010119-t1x9gknd 2496 4 at at IN cord-010119-t1x9gknd 2496 5 48C 48c CD cord-010119-t1x9gknd 2496 6 for for IN cord-010119-t1x9gknd 2496 7 up up IN cord-010119-t1x9gknd 2496 8 to to TO cord-010119-t1x9gknd 2496 9 42 42 CD cord-010119-t1x9gknd 2496 10 days day NNS cord-010119-t1x9gknd 2496 11 ; ; : cord-010119-t1x9gknd 2496 12 platelets platelet NNS cord-010119-t1x9gknd 2496 13 were be VBD cord-010119-t1x9gknd 2496 14 stored store VBN cord-010119-t1x9gknd 2496 15 at at IN cord-010119-t1x9gknd 2496 16 228C 228c CD cord-010119-t1x9gknd 2496 17 ( ( -LRB- cord-010119-t1x9gknd 2496 18 RT RT NNP cord-010119-t1x9gknd 2496 19 ) ) -RRB- cord-010119-t1x9gknd 2496 20 under under IN cord-010119-t1x9gknd 2496 21 agitation agitation NN cord-010119-t1x9gknd 2496 22 for for IN cord-010119-t1x9gknd 2496 23 5 5 CD cord-010119-t1x9gknd 2496 24 days day NNS cord-010119-t1x9gknd 2496 25 and and CC cord-010119-t1x9gknd 2496 26 plasma plasma NN cord-010119-t1x9gknd 2496 27 was be VBD cord-010119-t1x9gknd 2496 28 frozen freeze VBN cord-010119-t1x9gknd 2496 29 at at IN cord-010119-t1x9gknd 2496 30 -208C. -208C. NNP cord-010119-t1x9gknd 2496 31 Aliquots Aliquots NNP cord-010119-t1x9gknd 2496 32 for for IN cord-010119-t1x9gknd 2496 33 culture culture NN cord-010119-t1x9gknd 2496 34 were be VBD cord-010119-t1x9gknd 2496 35 removed remove VBN cord-010119-t1x9gknd 2496 36 weekly weekly RB cord-010119-t1x9gknd 2496 37 from from IN cord-010119-t1x9gknd 2496 38 RBCs rbc NNS cord-010119-t1x9gknd 2496 39 , , , cord-010119-t1x9gknd 2496 40 daily daily RB cord-010119-t1x9gknd 2496 41 from from IN cord-010119-t1x9gknd 2496 42 platelets platelet NNS cord-010119-t1x9gknd 2496 43 and and CC cord-010119-t1x9gknd 2496 44 after after IN cord-010119-t1x9gknd 2496 45 30 30 CD cord-010119-t1x9gknd 2496 46 days day NNS cord-010119-t1x9gknd 2496 47 from from IN cord-010119-t1x9gknd 2496 48 frozen frozen JJ cord-010119-t1x9gknd 2496 49 plasma plasma NN cord-010119-t1x9gknd 2496 50 . . . cord-010119-t1x9gknd 2497 1 All all DT cord-010119-t1x9gknd 2497 2 samples sample NNS cord-010119-t1x9gknd 2497 3 were be VBD cord-010119-t1x9gknd 2497 4 cultured culture VBN cord-010119-t1x9gknd 2497 5 in in IN cord-010119-t1x9gknd 2497 6 Liver Liver NNP cord-010119-t1x9gknd 2497 7 Infusion Infusion NNP cord-010119-t1x9gknd 2497 8 Tryptose Tryptose NNP cord-010119-t1x9gknd 2497 9 ( ( -LRB- cord-010119-t1x9gknd 2497 10 LIT LIT NNP cord-010119-t1x9gknd 2497 11 ) ) -RRB- cord-010119-t1x9gknd 2497 12 media medium NNS cord-010119-t1x9gknd 2497 13 at at IN cord-010119-t1x9gknd 2497 14 278C 278c CD cord-010119-t1x9gknd 2497 15 for for IN cord-010119-t1x9gknd 2497 16 detection detection NN cord-010119-t1x9gknd 2497 17 of of IN cord-010119-t1x9gknd 2497 18 live live JJ cord-010119-t1x9gknd 2497 19 parasites parasite NNS cord-010119-t1x9gknd 2497 20 for for IN cord-010119-t1x9gknd 2497 21 up up IN cord-010119-t1x9gknd 2497 22 to to TO cord-010119-t1x9gknd 2497 23 16 16 CD cord-010119-t1x9gknd 2497 24 weeks week NNS cord-010119-t1x9gknd 2497 25 . . . cord-010119-t1x9gknd 2498 1 Results/ Results/ . cord-010119-t1x9gknd 2499 1 Finding finding NN cord-010119-t1x9gknd 2499 2 : : : cord-010119-t1x9gknd 2500 1 Hemocultures hemoculture NNS cord-010119-t1x9gknd 2500 2 from from IN cord-010119-t1x9gknd 2500 3 spiked spiked JJ cord-010119-t1x9gknd 2500 4 - - HYPH cord-010119-t1x9gknd 2500 5 WB WB NNP cord-010119-t1x9gknd 2500 6 were be VBD cord-010119-t1x9gknd 2500 7 positive positive JJ cord-010119-t1x9gknd 2500 8 at at IN cord-010119-t1x9gknd 2500 9 all all DT cord-010119-t1x9gknd 2500 10 concentration concentration NN cord-010119-t1x9gknd 2500 11 of of IN cord-010119-t1x9gknd 2500 12 parasites parasite NNS cord-010119-t1x9gknd 2500 13 . . . cord-010119-t1x9gknd 2501 1 LR'd LR'd NNS cord-010119-t1x9gknd 2501 2 and and CC cord-010119-t1x9gknd 2501 3 non non JJ cord-010119-t1x9gknd 2501 4 - - JJ cord-010119-t1x9gknd 2501 5 LR'd lr'd JJ cord-010119-t1x9gknd 2501 6 RBCs rbc NNS cord-010119-t1x9gknd 2501 7 cultured culture VBN cord-010119-t1x9gknd 2501 8 before before IN cord-010119-t1x9gknd 2501 9 storage storage NN cord-010119-t1x9gknd 2501 10 were be VBD cord-010119-t1x9gknd 2501 11 positive positive JJ cord-010119-t1x9gknd 2501 12 at at IN cord-010119-t1x9gknd 2501 13 all all DT cord-010119-t1x9gknd 2501 14 concentrations concentration NNS cord-010119-t1x9gknd 2501 15 . . . cord-010119-t1x9gknd 2502 1 After after IN cord-010119-t1x9gknd 2502 2 storage storage NN cord-010119-t1x9gknd 2502 3 at at IN cord-010119-t1x9gknd 2502 4 48C 48c CD cord-010119-t1x9gknd 2502 5 , , , cord-010119-t1x9gknd 2502 6 RBCs rbc NNS cord-010119-t1x9gknd 2502 7 from from IN cord-010119-t1x9gknd 2502 8 all all DT cord-010119-t1x9gknd 2502 9 units unit NNS cord-010119-t1x9gknd 2502 10 spiked spike VBN cord-010119-t1x9gknd 2502 11 with with IN cord-010119-t1x9gknd 2502 12 10,000 10,000 CD cord-010119-t1x9gknd 2502 13 parasites parasite NNS cord-010119-t1x9gknd 2502 14 / / SYM cord-010119-t1x9gknd 2502 15 mL mL NNS cord-010119-t1x9gknd 2502 16 were be VBD cord-010119-t1x9gknd 2502 17 positive positive JJ cord-010119-t1x9gknd 2502 18 for for IN cord-010119-t1x9gknd 2502 19 up up IN cord-010119-t1x9gknd 2502 20 to to TO cord-010119-t1x9gknd 2502 21 21 21 CD cord-010119-t1x9gknd 2502 22 days day NNS cord-010119-t1x9gknd 2502 23 ; ; : cord-010119-t1x9gknd 2502 24 all all DT cord-010119-t1x9gknd 2502 25 further further JJ cord-010119-t1x9gknd 2502 26 times time NNS cord-010119-t1x9gknd 2502 27 yielded yield VBD cord-010119-t1x9gknd 2502 28 negative negative JJ cord-010119-t1x9gknd 2502 29 results result NNS cord-010119-t1x9gknd 2502 30 . . . cord-010119-t1x9gknd 2503 1 At at IN cord-010119-t1x9gknd 2503 2 lower low JJR cord-010119-t1x9gknd 2503 3 concentrations concentration NNS cord-010119-t1x9gknd 2503 4 , , , cord-010119-t1x9gknd 2503 5 only only RB cord-010119-t1x9gknd 2503 6 non non JJ cord-010119-t1x9gknd 2503 7 - - JJ cord-010119-t1x9gknd 2503 8 LR'd lr'd JJ cord-010119-t1x9gknd 2503 9 RBCs rbc NNS cord-010119-t1x9gknd 2503 10 spiked spike VBD cord-010119-t1x9gknd 2503 11 with with IN cord-010119-t1x9gknd 2503 12 1000 1000 CD cord-010119-t1x9gknd 2503 13 parasites parasite NNS cord-010119-t1x9gknd 2503 14 / / SYM cord-010119-t1x9gknd 2503 15 mL mL NNS cord-010119-t1x9gknd 2503 16 were be VBD cord-010119-t1x9gknd 2503 17 positive positive JJ cord-010119-t1x9gknd 2503 18 for for IN cord-010119-t1x9gknd 2503 19 up up IN cord-010119-t1x9gknd 2503 20 to to TO cord-010119-t1x9gknd 2503 21 7 7 CD cord-010119-t1x9gknd 2503 22 days day NNS cord-010119-t1x9gknd 2503 23 . . . cord-010119-t1x9gknd 2504 1 Plasma plasma NN cord-010119-t1x9gknd 2504 2 samples sample NNS cord-010119-t1x9gknd 2504 3 cultured culture VBN cord-010119-t1x9gknd 2504 4 before before IN cord-010119-t1x9gknd 2504 5 freezing freeze VBG cord-010119-t1x9gknd 2504 6 were be VBD cord-010119-t1x9gknd 2504 7 positive positive JJ cord-010119-t1x9gknd 2504 8 at at IN cord-010119-t1x9gknd 2504 9 the the DT cord-010119-t1x9gknd 2504 10 highest high JJS cord-010119-t1x9gknd 2504 11 concentration concentration NN cord-010119-t1x9gknd 2504 12 in in IN cord-010119-t1x9gknd 2504 13 one one CD cord-010119-t1x9gknd 2504 14 non non JJ cord-010119-t1x9gknd 2504 15 - - JJ cord-010119-t1x9gknd 2504 16 LR'd lr'd JJ cord-010119-t1x9gknd 2504 17 sample sample NN cord-010119-t1x9gknd 2504 18 , , , cord-010119-t1x9gknd 2504 19 while while IN cord-010119-t1x9gknd 2504 20 all all DT cord-010119-t1x9gknd 2504 21 others other NNS cord-010119-t1x9gknd 2504 22 were be VBD cord-010119-t1x9gknd 2504 23 negative negative JJ cord-010119-t1x9gknd 2504 24 . . . cord-010119-t1x9gknd 2505 1 Platelets platelet NNS cord-010119-t1x9gknd 2505 2 obtained obtain VBN cord-010119-t1x9gknd 2505 3 from from IN cord-010119-t1x9gknd 2505 4 WB WB NNP cord-010119-t1x9gknd 2505 5 spiked spike VBD cord-010119-t1x9gknd 2505 6 with with IN cord-010119-t1x9gknd 2506 1 10,000 10,000 CD cord-010119-t1x9gknd 2506 2 and and CC cord-010119-t1x9gknd 2506 3 1000 1000 CD cord-010119-t1x9gknd 2506 4 parasites parasite NNS cord-010119-t1x9gknd 2506 5 / / SYM cord-010119-t1x9gknd 2506 6 mL mL NNS cord-010119-t1x9gknd 2506 7 were be VBD cord-010119-t1x9gknd 2506 8 positive positive JJ cord-010119-t1x9gknd 2506 9 up up IN cord-010119-t1x9gknd 2506 10 to to TO cord-010119-t1x9gknd 2506 11 5 5 CD cord-010119-t1x9gknd 2506 12 days day NNS cord-010119-t1x9gknd 2506 13 at at IN cord-010119-t1x9gknd 2506 14 RT RT NNP cord-010119-t1x9gknd 2506 15 . . . cord-010119-t1x9gknd 2507 1 No no DT cord-010119-t1x9gknd 2507 2 parasites parasite NNS cord-010119-t1x9gknd 2507 3 were be VBD cord-010119-t1x9gknd 2507 4 observed observe VBN cord-010119-t1x9gknd 2507 5 in in IN cord-010119-t1x9gknd 2507 6 plasma plasma NN cord-010119-t1x9gknd 2507 7 or or CC cord-010119-t1x9gknd 2507 8 platelets platelet NNS cord-010119-t1x9gknd 2507 9 prior prior RB cord-010119-t1x9gknd 2507 10 to to IN cord-010119-t1x9gknd 2507 11 storage storage NN cord-010119-t1x9gknd 2507 12 at at IN cord-010119-t1x9gknd 2507 13 lower low JJR cord-010119-t1x9gknd 2507 14 concentrations concentration NNS cord-010119-t1x9gknd 2507 15 . . . cord-010119-t1x9gknd 2508 1 Molecular molecular JJ cord-010119-t1x9gknd 2508 2 analysis analysis NN cord-010119-t1x9gknd 2508 3 to to TO cord-010119-t1x9gknd 2508 4 determine determine VB cord-010119-t1x9gknd 2508 5 the the DT cord-010119-t1x9gknd 2508 6 presence presence NN cord-010119-t1x9gknd 2508 7 of of IN cord-010119-t1x9gknd 2508 8 parasite parasite NN cord-010119-t1x9gknd 2508 9 DNA dna NN cord-010119-t1x9gknd 2508 10 in in IN cord-010119-t1x9gknd 2508 11 each each DT cord-010119-t1x9gknd 2508 12 component component NN cord-010119-t1x9gknd 2508 13 is be VBZ cord-010119-t1x9gknd 2508 14 on on RB cord-010119-t1x9gknd 2508 15 - - HYPH cord-010119-t1x9gknd 2508 16 going going NN cord-010119-t1x9gknd 2508 17 . . . cord-010119-t1x9gknd 2509 1 Conclusion conclusion NN cord-010119-t1x9gknd 2509 2 : : : cord-010119-t1x9gknd 2510 1 Platelet platelet NN cord-010119-t1x9gknd 2510 2 storage storage NN cord-010119-t1x9gknd 2510 3 conditions condition NNS cord-010119-t1x9gknd 2510 4 offer offer VBP cord-010119-t1x9gknd 2510 5 a a DT cord-010119-t1x9gknd 2510 6 suitable suitable JJ cord-010119-t1x9gknd 2510 7 environment environment NN cord-010119-t1x9gknd 2510 8 for for IN cord-010119-t1x9gknd 2510 9 T. T. NNP cord-010119-t1x9gknd 2510 10 cruzi cruzi NNP cord-010119-t1x9gknd 2510 11 survival survival NN cord-010119-t1x9gknd 2510 12 ; ; : cord-010119-t1x9gknd 2510 13 however however RB cord-010119-t1x9gknd 2510 14 , , , cord-010119-t1x9gknd 2510 15 high high JJ cord-010119-t1x9gknd 2510 16 concentrations concentration NNS cord-010119-t1x9gknd 2510 17 of of IN cord-010119-t1x9gknd 2510 18 parasites parasite NNS cord-010119-t1x9gknd 2510 19 also also RB cord-010119-t1x9gknd 2510 20 survived survive VBD cord-010119-t1x9gknd 2510 21 in in IN cord-010119-t1x9gknd 2510 22 RBCs rbc NNS cord-010119-t1x9gknd 2510 23 at at IN cord-010119-t1x9gknd 2510 24 48C 48c CD cord-010119-t1x9gknd 2510 25 for for IN cord-010119-t1x9gknd 2510 26 up up IN cord-010119-t1x9gknd 2510 27 to to TO cord-010119-t1x9gknd 2510 28 3 3 CD cord-010119-t1x9gknd 2510 29 weeks week NNS cord-010119-t1x9gknd 2510 30 . . . cord-010119-t1x9gknd 2511 1 Leukoreduction leukoreduction NN cord-010119-t1x9gknd 2511 2 offers offer VBZ cord-010119-t1x9gknd 2511 3 partial partial JJ cord-010119-t1x9gknd 2511 4 protection protection NN cord-010119-t1x9gknd 2511 5 , , , cord-010119-t1x9gknd 2511 6 while while IN cord-010119-t1x9gknd 2511 7 freezing freeze VBG cord-010119-t1x9gknd 2511 8 conditions condition NNS cord-010119-t1x9gknd 2511 9 appears appear VBZ cord-010119-t1x9gknd 2511 10 unsuitable unsuitable JJ cord-010119-t1x9gknd 2511 11 for for IN cord-010119-t1x9gknd 2511 12 T. T. NNP cord-010119-t1x9gknd 2511 13 cruzi cruzi NNP cord-010119-t1x9gknd 2511 14 survival survival NN cord-010119-t1x9gknd 2511 15 . . . cord-010119-t1x9gknd 2512 1 Hemovigilance Hemovigilance NNP cord-010119-t1x9gknd 2512 2 Monitoring Monitoring NNP cord-010119-t1x9gknd 2512 3 of of IN cord-010119-t1x9gknd 2512 4 Platelet Platelet NNP cord-010119-t1x9gknd 2512 5 Septic Septic NNP cord-010119-t1x9gknd 2512 6 Transfusion Transfusion NNP cord-010119-t1x9gknd 2512 7 Reactions reaction NNS cord-010119-t1x9gknd 2512 8 ( ( -LRB- cord-010119-t1x9gknd 2512 9 STR str NN cord-010119-t1x9gknd 2512 10 ) ) -RRB- cord-010119-t1x9gknd 2512 11 after after IN cord-010119-t1x9gknd 2512 12 Treatment treatment NN cord-010119-t1x9gknd 2512 13 with with IN cord-010119-t1x9gknd 2512 14 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 2512 15 TM TM NNP cord-010119-t1x9gknd 2512 16 Pathogen Pathogen NNP cord-010119-t1x9gknd 2512 17 Reduction Reduction NNP cord-010119-t1x9gknd 2512 18 or or CC cord-010119-t1x9gknd 2512 19 Large Large NNP cord-010119-t1x9gknd 2512 20 Volume volume NN cord-010119-t1x9gknd 2512 21 , , , cord-010119-t1x9gknd 2512 22 Delayed delay VBN cord-010119-t1x9gknd 2512 23 Bact Bact NNP cord-010119-t1x9gknd 2512 24 / / SYM cord-010119-t1x9gknd 2512 25 ALERT ALERT NNP cord-010119-t1x9gknd 2512 26 TM TM NNP cord-010119-t1x9gknd 2512 27 Bacterial Bacterial NNP cord-010119-t1x9gknd 2512 28 Culture Culture NNP cord-010119-t1x9gknd 2512 29 Screening screening NN cord-010119-t1x9gknd 2513 1 Richard Richard NNP cord-010119-t1x9gknd 2513 2 Benjamin Benjamin NNP cord-010119-t1x9gknd 2513 3 * * NFP cord-010119-t1x9gknd 2513 4 1 1 CD cord-010119-t1x9gknd 2513 5 , , , cord-010119-t1x9gknd 2513 6 Marion Marion NNP cord-010119-t1x9gknd 2513 7 Lanteri Lanteri NNP cord-010119-t1x9gknd 2513 8 2 2 CD cord-010119-t1x9gknd 2513 9 and and CC cord-010119-t1x9gknd 2513 10 Larry Larry NNP cord-010119-t1x9gknd 2513 11 Corash Corash NNP cord-010119-t1x9gknd 2513 12 1 1 CD cord-010119-t1x9gknd 2513 13 . . . cord-010119-t1x9gknd 2514 1 1 1 CD cord-010119-t1x9gknd 2514 2 Cerus Cerus NNP cord-010119-t1x9gknd 2514 3 Corporation Corporation NNP cord-010119-t1x9gknd 2514 4 , , , cord-010119-t1x9gknd 2514 5 2 2 CD cord-010119-t1x9gknd 2514 6 Scientific Scientific NNP cord-010119-t1x9gknd 2514 7 Affairs Affairs NNPS cord-010119-t1x9gknd 2514 8 Department Department NNP cord-010119-t1x9gknd 2514 9 , , , cord-010119-t1x9gknd 2514 10 Cerus Cerus NNP cord-010119-t1x9gknd 2514 11 Corporation Corporation NNP cord-010119-t1x9gknd 2514 12 Background Background NNP cord-010119-t1x9gknd 2514 13 / / SYM cord-010119-t1x9gknd 2514 14 Case Case NNP cord-010119-t1x9gknd 2514 15 Studies Studies NNPS cord-010119-t1x9gknd 2514 16 : : : cord-010119-t1x9gknd 2515 1 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 2515 2 / / SYM cord-010119-t1x9gknd 2515 3 ultraviolet ultraviolet NN cord-010119-t1x9gknd 2515 4 A a NN cord-010119-t1x9gknd 2516 1 ( ( -LRB- cord-010119-t1x9gknd 2516 2 UVA UVA NNP cord-010119-t1x9gknd 2516 3 ) ) -RRB- cord-010119-t1x9gknd 2516 4 light light NN cord-010119-t1x9gknd 2517 1 ( ( -LRB- cord-010119-t1x9gknd 2517 2 INTER INTER NNP cord-010119-t1x9gknd 2517 3 - - HYPH cord-010119-t1x9gknd 2517 4 CEPT CEPT NNP cord-010119-t1x9gknd 2517 5 TM TM NNP cord-010119-t1x9gknd 2517 6 Blood Blood NNP cord-010119-t1x9gknd 2517 7 System System NNP cord-010119-t1x9gknd 2517 8 , , , cord-010119-t1x9gknd 2517 9 Cerus Cerus NNP cord-010119-t1x9gknd 2517 10 Corporation Corporation NNP cord-010119-t1x9gknd 2517 11 ) ) -RRB- cord-010119-t1x9gknd 2517 12 pathogen pathogen NN cord-010119-t1x9gknd 2517 13 reduction reduction NN cord-010119-t1x9gknd 2517 14 ( ( -LRB- cord-010119-t1x9gknd 2517 15 PR PR NNP cord-010119-t1x9gknd 2517 16 ) ) -RRB- cord-010119-t1x9gknd 2517 17 and and CC cord-010119-t1x9gknd 2517 18 delayed delay VBN cord-010119-t1x9gknd 2517 19 , , , cord-010119-t1x9gknd 2517 20 large large JJ cord-010119-t1x9gknd 2517 21 volume volume NN cord-010119-t1x9gknd 2517 22 , , , cord-010119-t1x9gknd 2517 23 bacterial bacterial JJ cord-010119-t1x9gknd 2517 24 culture culture NN cord-010119-t1x9gknd 2517 25 with with IN cord-010119-t1x9gknd 2517 26 the the DT cord-010119-t1x9gknd 2517 27 BacT BacT NNP cord-010119-t1x9gknd 2517 28 / / SYM cord-010119-t1x9gknd 2517 29 ALERT ALERT NNP cord-010119-t1x9gknd 2517 30 TM TM NNP cord-010119-t1x9gknd 2517 31 System system NN cord-010119-t1x9gknd 2517 32 ( ( -LRB- cord-010119-t1x9gknd 2517 33 DLVBC DLVBC NNP cord-010119-t1x9gknd 2517 34 ) ) -RRB- cord-010119-t1x9gknd 2518 1 ( ( -LRB- cord-010119-t1x9gknd 2518 2 BioMerieux BioMerieux NNP cord-010119-t1x9gknd 2518 3 , , , cord-010119-t1x9gknd 2518 4 Inc Inc NNP cord-010119-t1x9gknd 2518 5 ) ) -RRB- cord-010119-t1x9gknd 2518 6 represent represent VBP cord-010119-t1x9gknd 2518 7 respective respective JJ cord-010119-t1x9gknd 2518 8 best good JJS cord-010119-t1x9gknd 2518 9 - - HYPH cord-010119-t1x9gknd 2518 10 in in IN cord-010119-t1x9gknd 2518 11 - - HYPH cord-010119-t1x9gknd 2518 12 class class NN cord-010119-t1x9gknd 2518 13 systems system NNS cord-010119-t1x9gknd 2518 14 to to TO cord-010119-t1x9gknd 2518 15 reduce reduce VB cord-010119-t1x9gknd 2518 16 the the DT cord-010119-t1x9gknd 2518 17 risk risk NN cord-010119-t1x9gknd 2518 18 of of IN cord-010119-t1x9gknd 2518 19 STR STR NNP cord-010119-t1x9gknd 2518 20 associated associate VBN cord-010119-t1x9gknd 2518 21 with with IN cord-010119-t1x9gknd 2518 22 platelet platelet NN cord-010119-t1x9gknd 2518 23 concentrates concentrate NNS cord-010119-t1x9gknd 2518 24 ( ( -LRB- cord-010119-t1x9gknd 2518 25 PC pc NN cord-010119-t1x9gknd 2518 26 ) ) -RRB- cord-010119-t1x9gknd 2518 27 . . . cord-010119-t1x9gknd 2519 1 Where where WRB cord-010119-t1x9gknd 2519 2 implemented implement VBN cord-010119-t1x9gknd 2519 3 , , , cord-010119-t1x9gknd 2519 4 hemoviligance hemoviligance NNP cord-010119-t1x9gknd 2519 5 ( ( -LRB- cord-010119-t1x9gknd 2519 6 HV HV NNP cord-010119-t1x9gknd 2519 7 ) ) -RRB- cord-010119-t1x9gknd 2519 8 programs program NNS cord-010119-t1x9gknd 2519 9 continue continue VBP cord-010119-t1x9gknd 2519 10 to to TO cord-010119-t1x9gknd 2519 11 receive receive VB cord-010119-t1x9gknd 2519 12 reports report NNS cord-010119-t1x9gknd 2519 13 of of IN cord-010119-t1x9gknd 2519 14 suspected suspect VBN cord-010119-t1x9gknd 2519 15 STR STR NNP cord-010119-t1x9gknd 2519 16 , , , cord-010119-t1x9gknd 2519 17 most most JJS cord-010119-t1x9gknd 2519 18 of of IN cord-010119-t1x9gknd 2519 19 which which WDT cord-010119-t1x9gknd 2519 20 have have VBP cord-010119-t1x9gknd 2519 21 low low JJ cord-010119-t1x9gknd 2519 22 imputability imputability NN cord-010119-t1x9gknd 2519 23 as as IN cord-010119-t1x9gknd 2519 24 other other JJ cord-010119-t1x9gknd 2519 25 causes cause NNS cord-010119-t1x9gknd 2519 26 are be VBP cord-010119-t1x9gknd 2519 27 more more RBR cord-010119-t1x9gknd 2519 28 likely likely JJ cord-010119-t1x9gknd 2519 29 or or CC cord-010119-t1x9gknd 2519 30 insufficient insufficient JJ cord-010119-t1x9gknd 2519 31 information information NN cord-010119-t1x9gknd 2519 32 is be VBZ cord-010119-t1x9gknd 2519 33 available available JJ cord-010119-t1x9gknd 2519 34 to to TO cord-010119-t1x9gknd 2519 35 impute impute VB cord-010119-t1x9gknd 2519 36 system system NN cord-010119-t1x9gknd 2519 37 failure failure NN cord-010119-t1x9gknd 2519 38 . . . cord-010119-t1x9gknd 2520 1 Study Study NNP cord-010119-t1x9gknd 2520 2 Design Design NNP cord-010119-t1x9gknd 2520 3 / / SYM cord-010119-t1x9gknd 2520 4 Methods method NNS cord-010119-t1x9gknd 2520 5 : : : cord-010119-t1x9gknd 2520 6 United United NNP cord-010119-t1x9gknd 2520 7 Kingdom Kingdom NNP cord-010119-t1x9gknd 2520 8 ( ( -LRB- cord-010119-t1x9gknd 2520 9 2006 2006 CD cord-010119-t1x9gknd 2520 10 -2015 -2015 NNS cord-010119-t1x9gknd 2520 11 ) ) -RRB- cord-010119-t1x9gknd 2520 12 , , , cord-010119-t1x9gknd 2520 13 French French NNP cord-010119-t1x9gknd 2520 14 ( ( -LRB- cord-010119-t1x9gknd 2520 15 2006 2006 CD cord-010119-t1x9gknd 2520 16 -2015 -2015 NNS cord-010119-t1x9gknd 2520 17 , , , cord-010119-t1x9gknd 2520 18 Swiss Swiss NNP cord-010119-t1x9gknd 2520 19 ( ( -LRB- cord-010119-t1x9gknd 2520 20 2011 2011 CD cord-010119-t1x9gknd 2520 21 -2015 -2015 NNS cord-010119-t1x9gknd 2520 22 ) ) -RRB- cord-010119-t1x9gknd 2520 23 , , , cord-010119-t1x9gknd 2520 24 and and CC cord-010119-t1x9gknd 2520 25 Belgium(2009 belgium(2009 NN cord-010119-t1x9gknd 2520 26 -2015 -2015 NNP cord-010119-t1x9gknd 2520 27 HV HV NNP cord-010119-t1x9gknd 2520 28 reports report VBZ cord-010119-t1x9gknd 2520 29 , , , cord-010119-t1x9gknd 2520 30 and and CC cord-010119-t1x9gknd 2521 1 Cerus Cerus NNP cord-010119-t1x9gknd 2521 2 Corporation Corporation NNP cord-010119-t1x9gknd 2521 3 's 's POS cord-010119-t1x9gknd 2521 4 adverse adverse JJ cord-010119-t1x9gknd 2521 5 event event NN cord-010119-t1x9gknd 2521 6 records record NNS cord-010119-t1x9gknd 2521 7 were be VBD cord-010119-t1x9gknd 2521 8 reviewed review VBN cord-010119-t1x9gknd 2521 9 to to TO cord-010119-t1x9gknd 2521 10 assess assess VB cord-010119-t1x9gknd 2521 11 the the DT cord-010119-t1x9gknd 2521 12 residual residual JJ cord-010119-t1x9gknd 2521 13 risk risk NN cord-010119-t1x9gknd 2521 14 and and CC cord-010119-t1x9gknd 2521 15 imputability imputability NN cord-010119-t1x9gknd 2521 16 of of IN cord-010119-t1x9gknd 2521 17 STR STR NNP cord-010119-t1x9gknd 2521 18 with with IN cord-010119-t1x9gknd 2521 19 amotosalen amotosalen NNP cord-010119-t1x9gknd 2521 20 / / SYM cord-010119-t1x9gknd 2521 21 UVA UVA NNP cord-010119-t1x9gknd 2521 22 - - HYPH cord-010119-t1x9gknd 2521 23 treated treat VBN cord-010119-t1x9gknd 2521 24 or or CC cord-010119-t1x9gknd 2521 25 DLVBC DLVBC NNP cord-010119-t1x9gknd 2521 26 - - HYPH cord-010119-t1x9gknd 2521 27 screened screen VBN cord-010119-t1x9gknd 2521 28 PC pc NN cord-010119-t1x9gknd 2521 29 . . . cord-010119-t1x9gknd 2522 1 Results result NNS cord-010119-t1x9gknd 2522 2 / / SYM cord-010119-t1x9gknd 2522 3 Findings finding NNS cord-010119-t1x9gknd 2522 4 : : : cord-010119-t1x9gknd 2522 5 Approximately approximately RB cord-010119-t1x9gknd 2522 6 1.35 1.35 CD cord-010119-t1x9gknd 2522 7 million million CD cord-010119-t1x9gknd 2522 8 DLVBC DLVBC NNP cord-010119-t1x9gknd 2522 9 - - HYPH cord-010119-t1x9gknd 2522 10 screened screen VBN cord-010119-t1x9gknd 2522 11 were be VBD cord-010119-t1x9gknd 2522 12 issued issue VBN cord-010119-t1x9gknd 2522 13 with with IN cord-010119-t1x9gknd 2522 14 a a DT cord-010119-t1x9gknd 2522 15 7 7 CD cord-010119-t1x9gknd 2522 16 day day NN cord-010119-t1x9gknd 2522 17 outdate outdate RB cord-010119-t1x9gknd 2522 18 after after IN cord-010119-t1x9gknd 2522 19 release release NN cord-010119-t1x9gknd 2522 20 into into IN cord-010119-t1x9gknd 2522 21 inventory inventory NN cord-010119-t1x9gknd 2522 22 3 3 CD cord-010119-t1x9gknd 2522 23 days day NNS cord-010119-t1x9gknd 2522 24 after after IN cord-010119-t1x9gknd 2522 25 collection collection NN cord-010119-t1x9gknd 2522 26 , , , cord-010119-t1x9gknd 2522 27 and and CC cord-010119-t1x9gknd 2522 28 $ $ $ cord-010119-t1x9gknd 2522 29 2.3 2.3 CD cord-010119-t1x9gknd 2522 30 million million CD cord-010119-t1x9gknd 2522 31 amotosalen amotosalen NN cord-010119-t1x9gknd 2522 32 / / SYM cord-010119-t1x9gknd 2522 33 UVA UVA NNP cord-010119-t1x9gknd 2522 34 - - HYPH cord-010119-t1x9gknd 2522 35 treated treat VBN cord-010119-t1x9gknd 2522 36 PC pc NN cord-010119-t1x9gknd 2522 37 were be VBD cord-010119-t1x9gknd 2522 38 released release VBN cord-010119-t1x9gknd 2522 39 into into IN cord-010119-t1x9gknd 2522 40 inventory inventory NN cord-010119-t1x9gknd 2522 41 on on IN cord-010119-t1x9gknd 2522 42 day day NN cord-010119-t1x9gknd 2522 43 1 1 CD cord-010119-t1x9gknd 2522 44 or or CC cord-010119-t1x9gknd 2522 45 2 2 CD cord-010119-t1x9gknd 2522 46 , , , cord-010119-t1x9gknd 2522 47 with with IN cord-010119-t1x9gknd 2522 48 a a DT cord-010119-t1x9gknd 2522 49 5 5 CD cord-010119-t1x9gknd 2522 50 to to TO cord-010119-t1x9gknd 2522 51 7 7 CD cord-010119-t1x9gknd 2522 52 day day NN cord-010119-t1x9gknd 2522 53 shelf shelf NN cord-010119-t1x9gknd 2522 54 - - HYPH cord-010119-t1x9gknd 2522 55 life life NN cord-010119-t1x9gknd 2522 56 . . . cord-010119-t1x9gknd 2523 1 No no DT cord-010119-t1x9gknd 2523 2 septic septic JJ cord-010119-t1x9gknd 2523 3 fatalities fatality NNS cord-010119-t1x9gknd 2523 4 were be VBD cord-010119-t1x9gknd 2523 5 reported report VBN cord-010119-t1x9gknd 2523 6 with with IN cord-010119-t1x9gknd 2523 7 either either DT cord-010119-t1x9gknd 2523 8 technology technology NN cord-010119-t1x9gknd 2523 9 . . . cord-010119-t1x9gknd 2524 1 The the DT cord-010119-t1x9gknd 2524 2 French French NNP cord-010119-t1x9gknd 2524 3 , , , cord-010119-t1x9gknd 2524 4 Belgium Belgium NNP cord-010119-t1x9gknd 2524 5 and and CC cord-010119-t1x9gknd 2524 6 Swiss swiss JJ cord-010119-t1x9gknd 2524 7 HV HV NNP cord-010119-t1x9gknd 2524 8 programs program NNS cord-010119-t1x9gknd 2524 9 monitored monitor VBD cord-010119-t1x9gknd 2524 10 > > XX cord-010119-t1x9gknd 2524 11 2.83 2.83 CD cord-010119-t1x9gknd 2524 12 million million CD cord-010119-t1x9gknd 2524 13 conventional conventional JJ cord-010119-t1x9gknd 2524 14 , , , cord-010119-t1x9gknd 2524 15 non non JJ cord-010119-t1x9gknd 2524 16 - - JJ cord-010119-t1x9gknd 2524 17 DLVBC dlvbc JJ cord-010119-t1x9gknd 2524 18 - - HYPH cord-010119-t1x9gknd 2524 19 screened screen VBN cord-010119-t1x9gknd 2524 20 PC pc NN cord-010119-t1x9gknd 2524 21 and and CC cord-010119-t1x9gknd 2524 22 recorded record VBD cord-010119-t1x9gknd 2524 23 58 58 CD cord-010119-t1x9gknd 2524 24 STR str NN cord-010119-t1x9gknd 2524 25 and and CC cord-010119-t1x9gknd 2524 26 9 9 CD cord-010119-t1x9gknd 2524 27 fatalities fatality NNS cord-010119-t1x9gknd 2524 28 . . . cord-010119-t1x9gknd 2525 1 Concurrently concurrently RB cord-010119-t1x9gknd 2525 2 , , , cord-010119-t1x9gknd 2525 3 zero zero CD cord-010119-t1x9gknd 2525 4 definite definite JJ cord-010119-t1x9gknd 2525 5 and and CC cord-010119-t1x9gknd 2525 6 2 2 CD cord-010119-t1x9gknd 2525 7 possible possible JJ cord-010119-t1x9gknd 2525 8 STR str NN cord-010119-t1x9gknd 2525 9 were be VBD cord-010119-t1x9gknd 2525 10 reported report VBN cord-010119-t1x9gknd 2525 11 with with IN cord-010119-t1x9gknd 2525 12 607,871 607,871 CD cord-010119-t1x9gknd 2525 13 amotosalen amotosalen NN cord-010119-t1x9gknd 2525 14 / / SYM cord-010119-t1x9gknd 2525 15 UVA UVA NNP cord-010119-t1x9gknd 2525 16 - - HYPH cord-010119-t1x9gknd 2525 17 treated treat VBN cord-010119-t1x9gknd 2525 18 PC pc NN cord-010119-t1x9gknd 2525 19 , , , cord-010119-t1x9gknd 2525 20 significantly significantly RB cord-010119-t1x9gknd 2525 21 fewer few JJR cord-010119-t1x9gknd 2525 22 than than IN cord-010119-t1x9gknd 2525 23 with with IN cord-010119-t1x9gknd 2525 24 conventional conventional JJ cord-010119-t1x9gknd 2525 25 PC pc NN cord-010119-t1x9gknd 2525 26 ( ( -LRB- cord-010119-t1x9gknd 2525 27 Table table NN cord-010119-t1x9gknd 2525 28 1 1 CD cord-010119-t1x9gknd 2525 29 ) ) -RRB- cord-010119-t1x9gknd 2525 30 ( ( -LRB- cord-010119-t1x9gknd 2525 31 20.5 20.5 CD cord-010119-t1x9gknd 2525 32 STR str NN cord-010119-t1x9gknd 2525 33 per per IN cord-010119-t1x9gknd 2525 34 million million CD cord-010119-t1x9gknd 2525 35 vs. vs. IN cord-010119-t1x9gknd 2525 36 0.0 0.0 CD cord-010119-t1x9gknd 2525 37 per per IN cord-010119-t1x9gknd 2525 38 million million CD cord-010119-t1x9gknd 2525 39 , , , cord-010119-t1x9gknd 2525 40 P<0.001 P<0.001 NNP cord-010119-t1x9gknd 2525 41 ) ) -RRB- cord-010119-t1x9gknd 2525 42 . . . cord-010119-t1x9gknd 2526 1 One one CD cord-010119-t1x9gknd 2526 2 definite definite JJ cord-010119-t1x9gknd 2526 3 , , , cord-010119-t1x9gknd 2526 4 1 1 CD cord-010119-t1x9gknd 2526 5 possible possible JJ cord-010119-t1x9gknd 2526 6 , , , cord-010119-t1x9gknd 2526 7 7 7 CD cord-010119-t1x9gknd 2526 8 undetermined undetermined JJ cord-010119-t1x9gknd 2526 9 / / SYM cord-010119-t1x9gknd 2526 10 indeterminate indeterminate JJ cord-010119-t1x9gknd 2526 11 non non JJ cord-010119-t1x9gknd 2526 12 - - JJ cord-010119-t1x9gknd 2526 13 fatal fatal JJ cord-010119-t1x9gknd 2526 14 STR str NN cord-010119-t1x9gknd 2526 15 and and CC cord-010119-t1x9gknd 2526 16 5 5 CD cord-010119-t1x9gknd 2526 17 contaminated contaminate VBN cord-010119-t1x9gknd 2526 18 " " `` cord-010119-t1x9gknd 2526 19 near near IN cord-010119-t1x9gknd 2526 20 miss miss JJ cord-010119-t1x9gknd 2526 21 " " '' cord-010119-t1x9gknd 2526 22 PC PC NNP cord-010119-t1x9gknd 2526 23 were be VBD cord-010119-t1x9gknd 2526 24 reported report VBN cord-010119-t1x9gknd 2526 25 with with IN cord-010119-t1x9gknd 2526 26 1.35 1.35 CD cord-010119-t1x9gknd 2526 27 million million CD cord-010119-t1x9gknd 2526 28 DLVBC DLVBC NNP cord-010119-t1x9gknd 2526 29 - - HYPH cord-010119-t1x9gknd 2526 30 screened screen VBN cord-010119-t1x9gknd 2526 31 PC pc NN cord-010119-t1x9gknd 2526 32 between between IN cord-010119-t1x9gknd 2526 33 2010 2010 CD cord-010119-t1x9gknd 2526 34 and and CC cord-010119-t1x9gknd 2526 35 2015 2015 CD cord-010119-t1x9gknd 2526 36 , , , cord-010119-t1x9gknd 2526 37 for for IN cord-010119-t1x9gknd 2526 38 a a DT cord-010119-t1x9gknd 2526 39 reduced reduce VBN cord-010119-t1x9gknd 2526 40 falsenegative falsenegative JJ cord-010119-t1x9gknd 2526 41 rate rate NN cord-010119-t1x9gknd 2526 42 compared compare VBN cord-010119-t1x9gknd 2526 43 with with IN cord-010119-t1x9gknd 2526 44 the the DT cord-010119-t1x9gknd 2526 45 prior prior JJ cord-010119-t1x9gknd 2526 46 five five CD cord-010119-t1x9gknd 2526 47 years year NNS cord-010119-t1x9gknd 2526 48 ( ( -LRB- cord-010119-t1x9gknd 2526 49 3.7 3.7 CD cord-010119-t1x9gknd 2526 50 STR str NN cord-010119-t1x9gknd 2526 51 per per IN cord-010119-t1x9gknd 2526 52 million million CD cord-010119-t1x9gknd 2526 53 vs. vs. NN cord-010119-t1x9gknd 2526 54 16.3 16.3 CD cord-010119-t1x9gknd 2526 55 per per IN cord-010119-t1x9gknd 2526 56 million million CD cord-010119-t1x9gknd 2526 57 , , , cord-010119-t1x9gknd 2526 58 P p NN cord-010119-t1x9gknd 2526 59 < < XX cord-010119-t1x9gknd 2526 60 0.05 0.05 CD cord-010119-t1x9gknd 2526 61 ) ) -RRB- cord-010119-t1x9gknd 2526 62 . . . cord-010119-t1x9gknd 2527 1 HV HV NNP cord-010119-t1x9gknd 2527 2 programs program NNS cord-010119-t1x9gknd 2527 3 highlight highlight VBP cord-010119-t1x9gknd 2527 4 a a DT cord-010119-t1x9gknd 2527 5 major major JJ cord-010119-t1x9gknd 2527 6 weakness weakness NN cord-010119-t1x9gknd 2527 7 when when WRB cord-010119-t1x9gknd 2527 8 reporting report VBG cord-010119-t1x9gknd 2527 9 STR str NN cord-010119-t1x9gknd 2527 10 . . . cord-010119-t1x9gknd 2528 1 Stringent stringent JJ cord-010119-t1x9gknd 2528 2 criteria criterion NNS cord-010119-t1x9gknd 2528 3 are be VBP cord-010119-t1x9gknd 2528 4 used use VBN cord-010119-t1x9gknd 2528 5 to to TO cord-010119-t1x9gknd 2528 6 determine determine VB cord-010119-t1x9gknd 2528 7 definite definite JJ cord-010119-t1x9gknd 2528 8 imputability imputability NN cord-010119-t1x9gknd 2528 9 , , , cord-010119-t1x9gknd 2528 10 including include VBG cord-010119-t1x9gknd 2528 11 evidence evidence NN cord-010119-t1x9gknd 2528 12 of of IN cord-010119-t1x9gknd 2528 13 patient patient JJ cord-010119-t1x9gknd 2528 14 infection infection NN cord-010119-t1x9gknd 2528 15 , , , cord-010119-t1x9gknd 2528 16 PC pc NN cord-010119-t1x9gknd 2528 17 contamination contamination NN cord-010119-t1x9gknd 2528 18 and and CC cord-010119-t1x9gknd 2528 19 irrefutable irrefutable JJ cord-010119-t1x9gknd 2528 20 evidence evidence NN cord-010119-t1x9gknd 2528 21 of of IN cord-010119-t1x9gknd 2528 22 a a DT cord-010119-t1x9gknd 2528 23 donor donor NN cord-010119-t1x9gknd 2528 24 source source NN cord-010119-t1x9gknd 2528 25 , , , cord-010119-t1x9gknd 2528 26 with with IN cord-010119-t1x9gknd 2528 27 confirmation confirmation NN cord-010119-t1x9gknd 2528 28 of of IN cord-010119-t1x9gknd 2528 29 strain strain NN cord-010119-t1x9gknd 2528 30 identity identity NN cord-010119-t1x9gknd 2528 31 . . . cord-010119-t1x9gknd 2529 1 Reports report NNS cord-010119-t1x9gknd 2529 2 with with IN cord-010119-t1x9gknd 2529 3 incomplete incomplete JJ cord-010119-t1x9gknd 2529 4 investigations investigation NNS cord-010119-t1x9gknd 2529 5 are be VBP cord-010119-t1x9gknd 2529 6 considered consider VBN cord-010119-t1x9gknd 2529 7 undetermined undetermined JJ cord-010119-t1x9gknd 2529 8 or or CC cord-010119-t1x9gknd 2529 9 indeterminate indeterminate JJ cord-010119-t1x9gknd 2529 10 , , , cord-010119-t1x9gknd 2529 11 or or CC cord-010119-t1x9gknd 2529 12 possible possible JJ cord-010119-t1x9gknd 2529 13 sepsis sepsis NN cord-010119-t1x9gknd 2529 14 . . . cord-010119-t1x9gknd 2530 1 Some some DT cord-010119-t1x9gknd 2530 2 of of IN cord-010119-t1x9gknd 2530 3 these these DT cord-010119-t1x9gknd 2530 4 cases case NNS cord-010119-t1x9gknd 2530 5 are be VBP cord-010119-t1x9gknd 2530 6 almost almost RB cord-010119-t1x9gknd 2530 7 certainly certainly RB cord-010119-t1x9gknd 2530 8 due due JJ cord-010119-t1x9gknd 2530 9 to to IN cord-010119-t1x9gknd 2530 10 bacterial bacterial JJ cord-010119-t1x9gknd 2530 11 contamination contamination NN cord-010119-t1x9gknd 2530 12 of of IN cord-010119-t1x9gknd 2530 13 PC pc NN cord-010119-t1x9gknd 2530 14 , , , cord-010119-t1x9gknd 2530 15 suggesting suggest VBG cord-010119-t1x9gknd 2530 16 that that IN cord-010119-t1x9gknd 2530 17 the the DT cord-010119-t1x9gknd 2530 18 actual actual JJ cord-010119-t1x9gknd 2530 19 rates rate NNS cord-010119-t1x9gknd 2530 20 of of IN cord-010119-t1x9gknd 2530 21 sepsis sepsis NN cord-010119-t1x9gknd 2530 22 are be VBP cord-010119-t1x9gknd 2530 23 considerably considerably RB cord-010119-t1x9gknd 2530 24 higher high JJR cord-010119-t1x9gknd 2530 25 than than IN cord-010119-t1x9gknd 2530 26 that that DT cord-010119-t1x9gknd 2530 27 reported report VBN cord-010119-t1x9gknd 2530 28 by by IN cord-010119-t1x9gknd 2530 29 HV HV NNP cord-010119-t1x9gknd 2530 30 programs program NNS cord-010119-t1x9gknd 2530 31 . . . cord-010119-t1x9gknd 2531 1 Conclusion conclusion NN cord-010119-t1x9gknd 2531 2 : : : cord-010119-t1x9gknd 2531 3 Best good JJS cord-010119-t1x9gknd 2531 4 - - HYPH cord-010119-t1x9gknd 2531 5 in in IN cord-010119-t1x9gknd 2531 6 - - HYPH cord-010119-t1x9gknd 2531 7 class class NN cord-010119-t1x9gknd 2531 8 pathogen pathogen NN cord-010119-t1x9gknd 2531 9 reduction reduction NN cord-010119-t1x9gknd 2531 10 and and CC cord-010119-t1x9gknd 2531 11 bacterial bacterial JJ cord-010119-t1x9gknd 2531 12 culture culture NN cord-010119-t1x9gknd 2531 13 systems system NNS cord-010119-t1x9gknd 2531 14 reduce reduce VBP cord-010119-t1x9gknd 2531 15 STR STR NNP cord-010119-t1x9gknd 2531 16 risk risk NN cord-010119-t1x9gknd 2531 17 , , , cord-010119-t1x9gknd 2531 18 although although IN cord-010119-t1x9gknd 2531 19 underreporting underreporte VBG cord-010119-t1x9gknd 2531 20 and and CC cord-010119-t1x9gknd 2531 21 inadequate inadequate JJ cord-010119-t1x9gknd 2531 22 clinical clinical JJ cord-010119-t1x9gknd 2531 23 data datum NNS cord-010119-t1x9gknd 2531 24 may may MD cord-010119-t1x9gknd 2531 25 result result VB cord-010119-t1x9gknd 2531 26 in in IN cord-010119-t1x9gknd 2531 27 underestimation underestimation NN cord-010119-t1x9gknd 2531 28 of of IN cord-010119-t1x9gknd 2531 29 the the DT cord-010119-t1x9gknd 2531 30 true true JJ cord-010119-t1x9gknd 2531 31 rates rate NNS cord-010119-t1x9gknd 2531 32 . . . cord-010119-t1x9gknd 2532 1 Pathogen pathogen NN cord-010119-t1x9gknd 2532 2 reduction reduction NN cord-010119-t1x9gknd 2532 3 of of IN cord-010119-t1x9gknd 2532 4 Background Background NNP cord-010119-t1x9gknd 2532 5 / / SYM cord-010119-t1x9gknd 2532 6 Case Case NNP cord-010119-t1x9gknd 2532 7 Studies Studies NNPS cord-010119-t1x9gknd 2532 8 : : : cord-010119-t1x9gknd 2533 1 Despite despite IN cord-010119-t1x9gknd 2533 2 extant extant JJ cord-010119-t1x9gknd 2533 3 mitigation mitigation NN cord-010119-t1x9gknd 2533 4 measures measure NNS cord-010119-t1x9gknd 2533 5 ( ( -LRB- cord-010119-t1x9gknd 2533 6 e.g. e.g. IN cord-010119-t1x9gknd 2533 7 diversion diversion NN cord-010119-t1x9gknd 2533 8 pouches pouch NNS cord-010119-t1x9gknd 2533 9 and and CC cord-010119-t1x9gknd 2533 10 primary primary JJ cord-010119-t1x9gknd 2533 11 platelet platelet NN cord-010119-t1x9gknd 2533 12 culture culture NN cord-010119-t1x9gknd 2533 13 at at IN cord-010119-t1x9gknd 2533 14 the the DT cord-010119-t1x9gknd 2533 15 collection collection NN cord-010119-t1x9gknd 2533 16 facility facility NN cord-010119-t1x9gknd 2533 17 ) ) -RRB- cord-010119-t1x9gknd 2533 18 , , , cord-010119-t1x9gknd 2533 19 bacterial bacterial JJ cord-010119-t1x9gknd 2533 20 contamination contamination NN cord-010119-t1x9gknd 2533 21 of of IN cord-010119-t1x9gknd 2533 22 platelets platelet NNS cord-010119-t1x9gknd 2533 23 and and CC cord-010119-t1x9gknd 2533 24 associated associate VBD cord-010119-t1x9gknd 2533 25 septic septic JJ cord-010119-t1x9gknd 2533 26 transfusion transfusion NN cord-010119-t1x9gknd 2533 27 reactions reaction NNS cord-010119-t1x9gknd 2533 28 remains remain VBZ cord-010119-t1x9gknd 2533 29 a a DT cord-010119-t1x9gknd 2533 30 leading leading JJ cord-010119-t1x9gknd 2533 31 cause cause NN cord-010119-t1x9gknd 2533 32 of of IN cord-010119-t1x9gknd 2533 33 transfusion transfusion NN cord-010119-t1x9gknd 2533 34 - - HYPH cord-010119-t1x9gknd 2533 35 associated associate VBN cord-010119-t1x9gknd 2533 36 fatalities fatality NNS cord-010119-t1x9gknd 2533 37 in in IN cord-010119-t1x9gknd 2533 38 the the DT cord-010119-t1x9gknd 2533 39 United United NNP cord-010119-t1x9gknd 2533 40 States States NNP cord-010119-t1x9gknd 2533 41 ( ( -LRB- cord-010119-t1x9gknd 2533 42 US US NNP cord-010119-t1x9gknd 2533 43 ) ) -RRB- cord-010119-t1x9gknd 2533 44 . . . cord-010119-t1x9gknd 2534 1 Consequently consequently RB cord-010119-t1x9gknd 2534 2 , , , cord-010119-t1x9gknd 2534 3 the the DT cord-010119-t1x9gknd 2534 4 US US NNP cord-010119-t1x9gknd 2534 5 Food Food NNP cord-010119-t1x9gknd 2534 6 and and CC cord-010119-t1x9gknd 2534 7 Drug Drug NNP cord-010119-t1x9gknd 2534 8 Administration Administration NNP cord-010119-t1x9gknd 2534 9 has have VBZ cord-010119-t1x9gknd 2534 10 recommended recommend VBN cord-010119-t1x9gknd 2534 11 adoption adoption NN cord-010119-t1x9gknd 2534 12 of of IN cord-010119-t1x9gknd 2534 13 additional additional JJ cord-010119-t1x9gknd 2534 14 measures measure NNS cord-010119-t1x9gknd 2534 15 such such JJ cord-010119-t1x9gknd 2534 16 as as IN cord-010119-t1x9gknd 2534 17 point point NN cord-010119-t1x9gknd 2534 18 of of IN cord-010119-t1x9gknd 2534 19 release release NN cord-010119-t1x9gknd 2534 20 testing testing NN cord-010119-t1x9gknd 2534 21 ( ( -LRB- cord-010119-t1x9gknd 2534 22 PORt PORt NNP cord-010119-t1x9gknd 2534 23 ) ) -RRB- cord-010119-t1x9gknd 2534 24 and/or and/or CC cord-010119-t1x9gknd 2534 25 pathogen pathogen NN cord-010119-t1x9gknd 2534 26 reduction reduction NN cord-010119-t1x9gknd 2534 27 to to TO cord-010119-t1x9gknd 2534 28 safeguard safeguard VB cord-010119-t1x9gknd 2534 29 against against IN cord-010119-t1x9gknd 2534 30 transfusionassociated transfusionassociated JJ cord-010119-t1x9gknd 2534 31 sepsis sepsis NN cord-010119-t1x9gknd 2534 32 . . . cord-010119-t1x9gknd 2535 1 However however RB cord-010119-t1x9gknd 2535 2 , , , cord-010119-t1x9gknd 2535 3 PORt port NN cord-010119-t1x9gknd 2535 4 poses pose VBZ cord-010119-t1x9gknd 2535 5 logistical logistical JJ cord-010119-t1x9gknd 2535 6 challenges challenge NNS cord-010119-t1x9gknd 2535 7 , , , cord-010119-t1x9gknd 2535 8 particularly particularly RB cord-010119-t1x9gknd 2535 9 in in IN cord-010119-t1x9gknd 2535 10 institutions institution NNS cord-010119-t1x9gknd 2535 11 with with IN cord-010119-t1x9gknd 2535 12 high high JJ cord-010119-t1x9gknd 2535 13 - - HYPH cord-010119-t1x9gknd 2535 14 volume volume NN cord-010119-t1x9gknd 2535 15 platelet platelet NN cord-010119-t1x9gknd 2535 16 utilization utilization NN cord-010119-t1x9gknd 2535 17 , , , cord-010119-t1x9gknd 2535 18 while while IN cord-010119-t1x9gknd 2535 19 pathogen pathogen NN cord-010119-t1x9gknd 2535 20 reduction reduction NN cord-010119-t1x9gknd 2535 21 is be VBZ cord-010119-t1x9gknd 2535 22 a a DT cord-010119-t1x9gknd 2535 23 high high JJ cord-010119-t1x9gknd 2535 24 cost cost NN cord-010119-t1x9gknd 2535 25 intervention intervention NN cord-010119-t1x9gknd 2535 26 . . . cord-010119-t1x9gknd 2536 1 We -PRON- PRP cord-010119-t1x9gknd 2536 2 evaluated evaluate VBD cord-010119-t1x9gknd 2536 3 a a DT cord-010119-t1x9gknd 2536 4 second second JJ cord-010119-t1x9gknd 2536 5 bacterial bacterial JJ cord-010119-t1x9gknd 2536 6 culture culture NN cord-010119-t1x9gknd 2536 7 to to TO cord-010119-t1x9gknd 2536 8 contend contend VB cord-010119-t1x9gknd 2536 9 with with IN cord-010119-t1x9gknd 2536 10 residual residual JJ cord-010119-t1x9gknd 2536 11 risk risk NN cord-010119-t1x9gknd 2536 12 . . . cord-010119-t1x9gknd 2537 1 Study Study NNP cord-010119-t1x9gknd 2537 2 Design Design NNP cord-010119-t1x9gknd 2537 3 / / SYM cord-010119-t1x9gknd 2537 4 Method method NN cord-010119-t1x9gknd 2537 5 : : : cord-010119-t1x9gknd 2537 6 Phased phase VBN cord-010119-t1x9gknd 2537 7 implementation implementation NN cord-010119-t1x9gknd 2537 8 of of IN cord-010119-t1x9gknd 2537 9 secondary secondary JJ cord-010119-t1x9gknd 2537 10 bacterial bacterial JJ cord-010119-t1x9gknd 2537 11 culture culture NN cord-010119-t1x9gknd 2537 12 testing testing NN cord-010119-t1x9gknd 2538 1 ( ( -LRB- cord-010119-t1x9gknd 2538 2 BacT BacT NNP cord-010119-t1x9gknd 2538 3 / / SYM cord-010119-t1x9gknd 2538 4 ALERT ALERT NNP cord-010119-t1x9gknd 2538 5 TM TM NNP cord-010119-t1x9gknd 2538 6 , , , cord-010119-t1x9gknd 2538 7 BioMerieux BioMerieux NNP cord-010119-t1x9gknd 2538 8 , , , cord-010119-t1x9gknd 2538 9 Inc. Inc. NNP cord-010119-t1x9gknd 2538 10 , , , cord-010119-t1x9gknd 2538 11 Durham Durham NNP cord-010119-t1x9gknd 2538 12 , , , cord-010119-t1x9gknd 2538 13 NC NC NNP cord-010119-t1x9gknd 2538 14 ) ) -RRB- cord-010119-t1x9gknd 2538 15 was be VBD cord-010119-t1x9gknd 2538 16 initiated initiate VBN cord-010119-t1x9gknd 2538 17 in in IN cord-010119-t1x9gknd 2538 18 October October NNP cord-010119-t1x9gknd 2538 19 2016 2016 CD cord-010119-t1x9gknd 2538 20 for for IN cord-010119-t1x9gknd 2538 21 all all DT cord-010119-t1x9gknd 2538 22 platelets platelet NNS cord-010119-t1x9gknd 2538 23 received receive VBN cord-010119-t1x9gknd 2538 24 at at IN cord-010119-t1x9gknd 2538 25 our -PRON- PRP$ cord-010119-t1x9gknd 2538 26 institution institution NN cord-010119-t1x9gknd 2538 27 . . . cord-010119-t1x9gknd 2539 1 At at IN cord-010119-t1x9gknd 2539 2 time time NN cord-010119-t1x9gknd 2539 3 of of IN cord-010119-t1x9gknd 2539 4 receipt receipt NN cord-010119-t1x9gknd 2539 5 at at IN cord-010119-t1x9gknd 2539 6 the the DT cord-010119-t1x9gknd 2539 7 blood blood NN cord-010119-t1x9gknd 2539 8 bank bank NN cord-010119-t1x9gknd 2539 9 ( ( -LRB- cord-010119-t1x9gknd 2539 10 day day NN cord-010119-t1x9gknd 2539 11 3 3 CD cord-010119-t1x9gknd 2539 12 post post NN cord-010119-t1x9gknd 2539 13 collection collection NN cord-010119-t1x9gknd 2539 14 ) ) -RRB- cord-010119-t1x9gknd 2539 15 , , , cord-010119-t1x9gknd 2539 16 products product NNS cord-010119-t1x9gknd 2539 17 were be VBD cord-010119-t1x9gknd 2539 18 sampled sample VBN cord-010119-t1x9gknd 2539 19 using use VBG cord-010119-t1x9gknd 2539 20 a a DT cord-010119-t1x9gknd 2539 21 sterile sterile JJ cord-010119-t1x9gknd 2539 22 connection connection NN cord-010119-t1x9gknd 2539 23 device device NN cord-010119-t1x9gknd 2539 24 ( ( -LRB- cord-010119-t1x9gknd 2539 25 TSCD TSCD NNP cord-010119-t1x9gknd 2539 26 TM TM NNP cord-010119-t1x9gknd 2539 27 , , , cord-010119-t1x9gknd 2539 28 Terumo Terumo NNP cord-010119-t1x9gknd 2539 29 , , , cord-010119-t1x9gknd 2539 30 Elkton Elkton NNP cord-010119-t1x9gknd 2539 31 , , , cord-010119-t1x9gknd 2539 32 MD MD NNP cord-010119-t1x9gknd 2539 33 ) ) -RRB- cord-010119-t1x9gknd 2539 34 and and CC cord-010119-t1x9gknd 2539 35 a a DT cord-010119-t1x9gknd 2539 36 sampling sampling NN cord-010119-t1x9gknd 2539 37 kit kit NN cord-010119-t1x9gknd 2539 38 ( ( -LRB- cord-010119-t1x9gknd 2539 39 Sam Sam NNP cord-010119-t1x9gknd 2539 40 - - HYPH cord-010119-t1x9gknd 2539 41 pLok pLok NNP cord-010119-t1x9gknd 2539 42 TM TM NNP cord-010119-t1x9gknd 2539 43 Sampling Sampling NNP cord-010119-t1x9gknd 2539 44 Kit Kit NNP cord-010119-t1x9gknd 2539 45 , , , cord-010119-t1x9gknd 2539 46 10 10 CD cord-010119-t1x9gknd 2539 47 mL ml NN cord-010119-t1x9gknd 2539 48 , , , cord-010119-t1x9gknd 2539 49 ITL ITL NNP cord-010119-t1x9gknd 2539 50 BioMedical BioMedical NNP cord-010119-t1x9gknd 2539 51 , , , cord-010119-t1x9gknd 2539 52 Malaysia Malaysia NNP cord-010119-t1x9gknd 2539 53 ) ) -RRB- cord-010119-t1x9gknd 2539 54 . . . cord-010119-t1x9gknd 2540 1 Five five CD cord-010119-t1x9gknd 2540 2 mLs ml NNS cord-010119-t1x9gknd 2540 3 of of IN cord-010119-t1x9gknd 2540 4 product product NN cord-010119-t1x9gknd 2540 5 was be VBD cord-010119-t1x9gknd 2540 6 transferred transfer VBN cord-010119-t1x9gknd 2540 7 aseptically aseptically RB cord-010119-t1x9gknd 2540 8 to to IN cord-010119-t1x9gknd 2540 9 BacT BacT NNP cord-010119-t1x9gknd 2540 10 / / SYM cord-010119-t1x9gknd 2540 11 ALERT ALERT NNP cord-010119-t1x9gknd 2540 12 BPA BPA NNP cord-010119-t1x9gknd 2540 13 ( ( -LRB- cord-010119-t1x9gknd 2540 14 aerobic aerobic JJ cord-010119-t1x9gknd 2540 15 ) ) -RRB- cord-010119-t1x9gknd 2540 16 culture culture NN cord-010119-t1x9gknd 2540 17 bottles bottle NNS cord-010119-t1x9gknd 2540 18 using use VBG cord-010119-t1x9gknd 2540 19 the the DT cord-010119-t1x9gknd 2540 20 same same JJ cord-010119-t1x9gknd 2540 21 sampling sampling NN cord-010119-t1x9gknd 2540 22 device device NN cord-010119-t1x9gknd 2540 23 . . . cord-010119-t1x9gknd 2541 1 Inoculated inoculate VBN cord-010119-t1x9gknd 2541 2 culture culture NN cord-010119-t1x9gknd 2541 3 bottles bottle NNS cord-010119-t1x9gknd 2541 4 were be VBD cord-010119-t1x9gknd 2541 5 loaded load VBN cord-010119-t1x9gknd 2541 6 into into IN cord-010119-t1x9gknd 2541 7 the the DT cord-010119-t1x9gknd 2541 8 BacT BacT NNP cord-010119-t1x9gknd 2541 9 / / SYM cord-010119-t1x9gknd 2541 10 ALERT alert NN cord-010119-t1x9gknd 2541 11 incubator incubator NN cord-010119-t1x9gknd 2541 12 modules module NNS cord-010119-t1x9gknd 2541 13 and and CC cord-010119-t1x9gknd 2541 14 incubated incubate VBN cord-010119-t1x9gknd 2541 15 at at IN cord-010119-t1x9gknd 2541 16 35C 35c CD cord-010119-t1x9gknd 2541 17 for for IN cord-010119-t1x9gknd 2541 18 three three CD cord-010119-t1x9gknd 2541 19 days day NNS cord-010119-t1x9gknd 2541 20 . . . cord-010119-t1x9gknd 2542 1 Results result NNS cord-010119-t1x9gknd 2542 2 / / SYM cord-010119-t1x9gknd 2542 3 Finding finding NN cord-010119-t1x9gknd 2542 4 : : : cord-010119-t1x9gknd 2542 5 A a DT cord-010119-t1x9gknd 2542 6 total total NN cord-010119-t1x9gknd 2542 7 of of IN cord-010119-t1x9gknd 2542 8 9473/11,066 9473/11,066 CD cord-010119-t1x9gknd 2542 9 ( ( -LRB- cord-010119-t1x9gknd 2542 10 85.6 85.6 CD cord-010119-t1x9gknd 2542 11 % % NN cord-010119-t1x9gknd 2542 12 ) ) -RRB- cord-010119-t1x9gknd 2543 1 platelet platelet NN cord-010119-t1x9gknd 2543 2 products product NNS cord-010119-t1x9gknd 2543 3 were be VBD cord-010119-t1x9gknd 2543 4 successfully successfully RB cord-010119-t1x9gknd 2543 5 cultured cultured JJ cord-010119-t1x9gknd 2543 6 ( ( -LRB- cord-010119-t1x9gknd 2543 7 934/1373 934/1373 CD cord-010119-t1x9gknd 2543 8 [ [ -LRB- cord-010119-t1x9gknd 2543 9 68.03 68.03 CD cord-010119-t1x9gknd 2543 10 % % NN cord-010119-t1x9gknd 2543 11 ] ] -RRB- cord-010119-t1x9gknd 2543 12 and and CC cord-010119-t1x9gknd 2543 13 1842/1912 1842/1912 CD cord-010119-t1x9gknd 2543 14 [ [ -LRB- cord-010119-t1x9gknd 2543 15 96.3 96.3 CD cord-010119-t1x9gknd 2543 16 % % NN cord-010119-t1x9gknd 2543 17 ] ] -RRB- cord-010119-t1x9gknd 2543 18 in in IN cord-010119-t1x9gknd 2543 19 October October NNP cord-010119-t1x9gknd 2543 20 2016 2016 CD cord-010119-t1x9gknd 2543 21 and and CC cord-010119-t1x9gknd 2543 22 March March NNP cord-010119-t1x9gknd 2543 23 2017 2017 CD cord-010119-t1x9gknd 2543 24 respectively respectively RB cord-010119-t1x9gknd 2543 25 ) ) -RRB- cord-010119-t1x9gknd 2543 26 . . . cord-010119-t1x9gknd 2544 1 Over over IN cord-010119-t1x9gknd 2544 2 the the DT cord-010119-t1x9gknd 2544 3 6-month 6-month CD cord-010119-t1x9gknd 2544 4 period period NN cord-010119-t1x9gknd 2544 5 , , , cord-010119-t1x9gknd 2544 6 two two CD cord-010119-t1x9gknd 2544 7 true true JJ cord-010119-t1x9gknd 2544 8 positive positive JJ cord-010119-t1x9gknd 2544 9 cultures culture NNS cord-010119-t1x9gknd 2544 10 were be VBD cord-010119-t1x9gknd 2544 11 obtained obtain VBN cord-010119-t1x9gknd 2544 12 ( ( -LRB- cord-010119-t1x9gknd 2544 13 incidence incidence NN cord-010119-t1x9gknd 2544 14 of of IN cord-010119-t1x9gknd 2544 15 1 1 CD cord-010119-t1x9gknd 2544 16 in in IN cord-010119-t1x9gknd 2544 17 4736 4736 CD cord-010119-t1x9gknd 2544 18 platelet platelet NN cord-010119-t1x9gknd 2544 19 products product NNS cord-010119-t1x9gknd 2544 20 ) ) -RRB- cord-010119-t1x9gknd 2544 21 . . . cord-010119-t1x9gknd 2545 1 The the DT cord-010119-t1x9gknd 2545 2 cultures culture NNS cord-010119-t1x9gknd 2545 3 grew grow VBD cord-010119-t1x9gknd 2545 4 Acinetobacter Acinetobacter NNP cord-010119-t1x9gknd 2545 5 species specie NNS cord-010119-t1x9gknd 2545 6 ( ( -LRB- cord-010119-t1x9gknd 2545 7 Case case NN cord-010119-t1x9gknd 2545 8 A A NNP cord-010119-t1x9gknd 2545 9 ) ) -RRB- cord-010119-t1x9gknd 2545 10 and and CC cord-010119-t1x9gknd 2545 11 coagulase coagulase VB cord-010119-t1x9gknd 2545 12 negative negative JJ cord-010119-t1x9gknd 2545 13 Staphylococcus Staphylococcus NNP cord-010119-t1x9gknd 2545 14 species specie NNS cord-010119-t1x9gknd 2545 15 ( ( -LRB- cord-010119-t1x9gknd 2545 16 Case case NN cord-010119-t1x9gknd 2545 17 B B NNP cord-010119-t1x9gknd 2545 18 ) ) -RRB- cord-010119-t1x9gknd 2545 19 ; ; : cord-010119-t1x9gknd 2545 20 both both DT cord-010119-t1x9gknd 2545 21 positive positive JJ cord-010119-t1x9gknd 2545 22 results result NNS cord-010119-t1x9gknd 2545 23 were be VBD cord-010119-t1x9gknd 2545 24 obtained obtain VBN cord-010119-t1x9gknd 2545 25 four four CD cord-010119-t1x9gknd 2545 26 days day NNS cord-010119-t1x9gknd 2545 27 following follow VBG cord-010119-t1x9gknd 2545 28 collection collection NN cord-010119-t1x9gknd 2545 29 . . . cord-010119-t1x9gknd 2546 1 Repeat repeat NN cord-010119-t1x9gknd 2546 2 testing testing NN cord-010119-t1x9gknd 2546 3 of of IN cord-010119-t1x9gknd 2547 1 Cases case NNS cord-010119-t1x9gknd 2547 2 A a VBP cord-010119-t1x9gknd 2547 3 and and CC cord-010119-t1x9gknd 2547 4 B B NNP cord-010119-t1x9gknd 2547 5 grew grow VBD cord-010119-t1x9gknd 2547 6 the the DT cord-010119-t1x9gknd 2547 7 same same JJ cord-010119-t1x9gknd 2547 8 organisms organism NNS cord-010119-t1x9gknd 2547 9 identified identify VBN cord-010119-t1x9gknd 2547 10 in in IN cord-010119-t1x9gknd 2547 11 the the DT cord-010119-t1x9gknd 2547 12 initial initial JJ cord-010119-t1x9gknd 2547 13 cultures culture NNS cord-010119-t1x9gknd 2547 14 . . . cord-010119-t1x9gknd 2548 1 There there EX cord-010119-t1x9gknd 2548 2 was be VBD cord-010119-t1x9gknd 2548 3 a a DT cord-010119-t1x9gknd 2548 4 co co NN cord-010119-t1x9gknd 2548 5 - - NN cord-010119-t1x9gknd 2548 6 component component NN cord-010119-t1x9gknd 2548 7 in in IN cord-010119-t1x9gknd 2548 8 our -PRON- PRP$ cord-010119-t1x9gknd 2548 9 inventory inventory NN cord-010119-t1x9gknd 2548 10 ( ( -LRB- cord-010119-t1x9gknd 2548 11 Case case NN cord-010119-t1x9gknd 2548 12 A A NNP cord-010119-t1x9gknd 2548 13 ) ) -RRB- cord-010119-t1x9gknd 2548 14 with with IN cord-010119-t1x9gknd 2548 15 negative negative JJ cord-010119-t1x9gknd 2548 16 initial initial NN cord-010119-t1x9gknd 2548 17 and and CC cord-010119-t1x9gknd 2548 18 repeat repeat VB cord-010119-t1x9gknd 2548 19 cultures culture NNS cord-010119-t1x9gknd 2548 20 . . . cord-010119-t1x9gknd 2549 1 None none NN cord-010119-t1x9gknd 2549 2 of of IN cord-010119-t1x9gknd 2549 3 the the DT cord-010119-t1x9gknd 2549 4 products product NNS cord-010119-t1x9gknd 2549 5 were be VBD cord-010119-t1x9gknd 2549 6 released release VBN cord-010119-t1x9gknd 2549 7 for for IN cord-010119-t1x9gknd 2549 8 transfusion transfusion NN cord-010119-t1x9gknd 2549 9 . . . cord-010119-t1x9gknd 2550 1 The the DT cord-010119-t1x9gknd 2550 2 initial initial JJ cord-010119-t1x9gknd 2550 3 post post JJ cord-010119-t1x9gknd 2550 4 - - JJ cord-010119-t1x9gknd 2550 5 collection collection JJ cord-010119-t1x9gknd 2550 6 product product NN cord-010119-t1x9gknd 2550 7 cultures culture NNS cord-010119-t1x9gknd 2550 8 remained remain VBD cord-010119-t1x9gknd 2550 9 negative negative JJ cord-010119-t1x9gknd 2550 10 at at IN cord-010119-t1x9gknd 2550 11 the the DT cord-010119-t1x9gknd 2550 12 collection collection NN cord-010119-t1x9gknd 2550 13 facility facility NN cord-010119-t1x9gknd 2550 14 . . . cord-010119-t1x9gknd 2551 1 Over over IN cord-010119-t1x9gknd 2551 2 the the DT cord-010119-t1x9gknd 2551 3 same same JJ cord-010119-t1x9gknd 2551 4 time time NN cord-010119-t1x9gknd 2551 5 period period NN cord-010119-t1x9gknd 2551 6 , , , cord-010119-t1x9gknd 2551 7 no no DT cord-010119-t1x9gknd 2551 8 false false JJ cord-010119-t1x9gknd 2551 9 positives positive NNS cord-010119-t1x9gknd 2551 10 were be VBD cord-010119-t1x9gknd 2551 11 detected detect VBN cord-010119-t1x9gknd 2551 12 . . . cord-010119-t1x9gknd 2552 1 Implementation implementation NN cord-010119-t1x9gknd 2552 2 required require VBD cord-010119-t1x9gknd 2552 3 hiring hire VBG cord-010119-t1x9gknd 2552 4 one one CD cord-010119-t1x9gknd 2552 5 additional additional JJ cord-010119-t1x9gknd 2552 6 dedicated dedicate VBN cord-010119-t1x9gknd 2552 7 FTE FTE NNP cord-010119-t1x9gknd 2552 8 ; ; : cord-010119-t1x9gknd 2552 9 the the DT cord-010119-t1x9gknd 2552 10 total total JJ cord-010119-t1x9gknd 2552 11 cost cost NN cord-010119-t1x9gknd 2552 12 ( ( -LRB- cord-010119-t1x9gknd 2552 13 technologist technologist NN cord-010119-t1x9gknd 2552 14 time time NN cord-010119-t1x9gknd 2552 15 , , , cord-010119-t1x9gknd 2552 16 equipment equipment NN cord-010119-t1x9gknd 2552 17 and and CC cord-010119-t1x9gknd 2552 18 related related JJ cord-010119-t1x9gknd 2552 19 supplies supply NNS cord-010119-t1x9gknd 2552 20 ) ) -RRB- cord-010119-t1x9gknd 2552 21 was be VBD cord-010119-t1x9gknd 2552 22 calculated calculate VBN cord-010119-t1x9gknd 2552 23 to to TO cord-010119-t1x9gknd 2552 24 be be VB cord-010119-t1x9gknd 2552 25 $ $ $ cord-010119-t1x9gknd 2552 26 US16.83 US16.83 NNP cord-010119-t1x9gknd 2552 27 per per IN cord-010119-t1x9gknd 2552 28 product product NN cord-010119-t1x9gknd 2552 29 tested test VBN cord-010119-t1x9gknd 2552 30 . . . cord-010119-t1x9gknd 2553 1 The the DT cord-010119-t1x9gknd 2553 2 cost cost NN cord-010119-t1x9gknd 2553 3 per per IN cord-010119-t1x9gknd 2553 4 averted avert VBN cord-010119-t1x9gknd 2553 5 case case NN cord-010119-t1x9gknd 2553 6 was be VBD cord-010119-t1x9gknd 2553 7 $ $ $ cord-010119-t1x9gknd 2553 8 US79,707 US79,707 NNP cord-010119-t1x9gknd 2553 9 . . . cord-010119-t1x9gknd 2554 1 Conclusion conclusion NN cord-010119-t1x9gknd 2554 2 : : : cord-010119-t1x9gknd 2555 1 We -PRON- PRP cord-010119-t1x9gknd 2555 2 demonstrate demonstrate VBP cord-010119-t1x9gknd 2555 3 the the DT cord-010119-t1x9gknd 2555 4 feasibility feasibility NN cord-010119-t1x9gknd 2555 5 of of IN cord-010119-t1x9gknd 2555 6 implementation implementation NN cord-010119-t1x9gknd 2555 7 of of IN cord-010119-t1x9gknd 2555 8 a a DT cord-010119-t1x9gknd 2555 9 secondary secondary JJ cord-010119-t1x9gknd 2555 10 bacterial bacterial JJ cord-010119-t1x9gknd 2555 11 culture culture NN cord-010119-t1x9gknd 2555 12 test test NN cord-010119-t1x9gknd 2555 13 of of IN cord-010119-t1x9gknd 2555 14 apheresis apheresis NN cord-010119-t1x9gknd 2555 15 platelets platelet NNS cord-010119-t1x9gknd 2555 16 to to TO cord-010119-t1x9gknd 2555 17 interdict interdict VB cord-010119-t1x9gknd 2555 18 bacterially bacterially RB cord-010119-t1x9gknd 2555 19 contaminated contaminated JJ cord-010119-t1x9gknd 2555 20 units unit NNS cord-010119-t1x9gknd 2555 21 and and CC cord-010119-t1x9gknd 2555 22 prevent prevent VB cord-010119-t1x9gknd 2555 23 septic septic JJ cord-010119-t1x9gknd 2555 24 transfusion transfusion NN cord-010119-t1x9gknd 2555 25 reactions reaction NNS cord-010119-t1x9gknd 2555 26 . . . cord-010119-t1x9gknd 2556 1 This this DT cord-010119-t1x9gknd 2556 2 presents present VBZ cord-010119-t1x9gknd 2556 3 a a DT cord-010119-t1x9gknd 2556 4 low low JJ cord-010119-t1x9gknd 2556 5 - - HYPH cord-010119-t1x9gknd 2556 6 cost cost NN cord-010119-t1x9gknd 2556 7 strategy strategy NN cord-010119-t1x9gknd 2556 8 ( ( -LRB- cord-010119-t1x9gknd 2556 9 as as IN cord-010119-t1x9gknd 2556 10 compared compare VBN cord-010119-t1x9gknd 2556 11 to to IN cord-010119-t1x9gknd 2556 12 pathogen pathogen NN cord-010119-t1x9gknd 2556 13 reduction reduction NN cord-010119-t1x9gknd 2556 14 ) ) -RRB- cord-010119-t1x9gknd 2556 15 to to TO cord-010119-t1x9gknd 2556 16 mitigate mitigate VB cord-010119-t1x9gknd 2556 17 risk risk NN cord-010119-t1x9gknd 2556 18 of of IN cord-010119-t1x9gknd 2556 19 septic septic JJ cord-010119-t1x9gknd 2556 20 transfusion transfusion NN cord-010119-t1x9gknd 2556 21 reactions reaction NNS cord-010119-t1x9gknd 2556 22 . . . cord-010119-t1x9gknd 2557 1 Importantly importantly RB cord-010119-t1x9gknd 2557 2 , , , cord-010119-t1x9gknd 2557 3 it -PRON- PRP cord-010119-t1x9gknd 2557 4 offers offer VBZ cord-010119-t1x9gknd 2557 5 a a DT cord-010119-t1x9gknd 2557 6 viable viable JJ cord-010119-t1x9gknd 2557 7 alternative alternative NN cord-010119-t1x9gknd 2557 8 to to IN cord-010119-t1x9gknd 2557 9 PORt PORt NNS cord-010119-t1x9gknd 2557 10 in in IN cord-010119-t1x9gknd 2557 11 high high JJ cord-010119-t1x9gknd 2557 12 volume volume NN cord-010119-t1x9gknd 2557 13 institutions institution NNS cord-010119-t1x9gknd 2557 14 where where WRB cord-010119-t1x9gknd 2557 15 logistic logistic JJ cord-010119-t1x9gknd 2557 16 ( ( -LRB- cord-010119-t1x9gknd 2557 17 e.g. e.g. JJ cord-010119-t1x9gknd 2557 18 time time NN cord-010119-t1x9gknd 2557 19 and and CC cord-010119-t1x9gknd 2557 20 personnel personnel NNS cord-010119-t1x9gknd 2557 21 ) ) -RRB- cord-010119-t1x9gknd 2557 22 constraints constraint NNS cord-010119-t1x9gknd 2557 23 impede impede VBP cord-010119-t1x9gknd 2557 24 practical practical JJ cord-010119-t1x9gknd 2557 25 adoption adoption NN cord-010119-t1x9gknd 2557 26 of of IN cord-010119-t1x9gknd 2557 27 PORt PORt NNS cord-010119-t1x9gknd 2557 28 . . . cord-010119-t1x9gknd 2558 1 An an DT cord-010119-t1x9gknd 2558 2 increase increase NN cord-010119-t1x9gknd 2558 3 in in IN cord-010119-t1x9gknd 2558 4 cases case NNS cord-010119-t1x9gknd 2558 5 of of IN cord-010119-t1x9gknd 2558 6 blood blood NN cord-010119-t1x9gknd 2558 7 culture culture NN cord-010119-t1x9gknd 2558 8 positive positive JJ cord-010119-t1x9gknd 2558 9 transfusion transfusion NN cord-010119-t1x9gknd 2558 10 reactions reaction NNS cord-010119-t1x9gknd 2558 11 ( ( -LRB- cord-010119-t1x9gknd 2558 12 BCPTR BCPTR NNP cord-010119-t1x9gknd 2558 13 ) ) -RRB- cord-010119-t1x9gknd 2558 14 was be VBD cord-010119-t1x9gknd 2558 15 noted note VBN cord-010119-t1x9gknd 2558 16 at at IN cord-010119-t1x9gknd 2558 17 our -PRON- PRP$ cord-010119-t1x9gknd 2558 18 hospital hospital NN cord-010119-t1x9gknd 2558 19 ; ; : cord-010119-t1x9gknd 2558 20 BCPTR BCPTR NNP cord-010119-t1x9gknd 2558 21 was be VBD cord-010119-t1x9gknd 2558 22 defined define VBN cord-010119-t1x9gknd 2558 23 as as IN cord-010119-t1x9gknd 2558 24 bacterial bacterial JJ cord-010119-t1x9gknd 2558 25 culture culture NN cord-010119-t1x9gknd 2558 26 positivity positivity NN cord-010119-t1x9gknd 2558 27 in in IN cord-010119-t1x9gknd 2558 28 the the DT cord-010119-t1x9gknd 2558 29 transfusion transfusion NN cord-010119-t1x9gknd 2558 30 recipient recipient NN cord-010119-t1x9gknd 2559 1 and/or and/or CC cord-010119-t1x9gknd 2559 2 associated associate VBD cord-010119-t1x9gknd 2559 3 transfused transfuse VBN cord-010119-t1x9gknd 2559 4 blood blood NN cord-010119-t1x9gknd 2559 5 product product NN cord-010119-t1x9gknd 2559 6 during during IN cord-010119-t1x9gknd 2559 7 investigation investigation NN cord-010119-t1x9gknd 2559 8 of of IN cord-010119-t1x9gknd 2559 9 a a DT cord-010119-t1x9gknd 2559 10 transfusion transfusion NN cord-010119-t1x9gknd 2559 11 reaction reaction NN cord-010119-t1x9gknd 2559 12 . . . cord-010119-t1x9gknd 2560 1 We -PRON- PRP cord-010119-t1x9gknd 2560 2 sought seek VBD cord-010119-t1x9gknd 2560 3 to to TO cord-010119-t1x9gknd 2560 4 characterize characterize VB cord-010119-t1x9gknd 2560 5 the the DT cord-010119-t1x9gknd 2560 6 risk risk NN cord-010119-t1x9gknd 2560 7 and and CC cord-010119-t1x9gknd 2560 8 clinical clinical JJ cord-010119-t1x9gknd 2560 9 presentation presentation NN cord-010119-t1x9gknd 2560 10 of of IN cord-010119-t1x9gknd 2560 11 BCPTR BCPTR NNP cord-010119-t1x9gknd 2560 12 at at IN cord-010119-t1x9gknd 2560 13 our -PRON- PRP$ cord-010119-t1x9gknd 2560 14 institution institution NN cord-010119-t1x9gknd 2560 15 . . . cord-010119-t1x9gknd 2561 1 Study Study NNP cord-010119-t1x9gknd 2561 2 Design Design NNP cord-010119-t1x9gknd 2561 3 / / SYM cord-010119-t1x9gknd 2561 4 Method method NN cord-010119-t1x9gknd 2561 5 : : : cord-010119-t1x9gknd 2562 1 An an DT cord-010119-t1x9gknd 2562 2 analysis analysis NN cord-010119-t1x9gknd 2562 3 was be VBD cord-010119-t1x9gknd 2562 4 conducted conduct VBN cord-010119-t1x9gknd 2562 5 of of IN cord-010119-t1x9gknd 2562 6 all all DT cord-010119-t1x9gknd 2562 7 reported report VBN cord-010119-t1x9gknd 2562 8 transfusion transfusion NN cord-010119-t1x9gknd 2562 9 reactions reaction NNS cord-010119-t1x9gknd 2562 10 at at IN cord-010119-t1x9gknd 2562 11 Johns Johns NNP cord-010119-t1x9gknd 2562 12 Hopkins Hopkins NNP cord-010119-t1x9gknd 2562 13 Hospital Hospital NNP cord-010119-t1x9gknd 2562 14 ( ( -LRB- cord-010119-t1x9gknd 2562 15 JHH JHH NNP cord-010119-t1x9gknd 2562 16 ) ) -RRB- cord-010119-t1x9gknd 2562 17 between between IN cord-010119-t1x9gknd 2562 18 January January NNP cord-010119-t1x9gknd 2562 19 2009 2009 CD cord-010119-t1x9gknd 2562 20 and and CC cord-010119-t1x9gknd 2562 21 December December NNP cord-010119-t1x9gknd 2562 22 2016 2016 CD cord-010119-t1x9gknd 2562 23 . . . cord-010119-t1x9gknd 2563 1 The the DT cord-010119-t1x9gknd 2563 2 data datum NNS cord-010119-t1x9gknd 2563 3 , , , cord-010119-t1x9gknd 2563 4 extracted extract VBN cord-010119-t1x9gknd 2563 5 from from IN cord-010119-t1x9gknd 2563 6 hemovigilance hemovigilance NN cord-010119-t1x9gknd 2563 7 records record NNS cord-010119-t1x9gknd 2563 8 , , , cord-010119-t1x9gknd 2563 9 were be VBD cord-010119-t1x9gknd 2563 10 evaluated evaluate VBN cord-010119-t1x9gknd 2563 11 to to TO cord-010119-t1x9gknd 2563 12 determine determine VB cord-010119-t1x9gknd 2563 13 the the DT cord-010119-t1x9gknd 2563 14 incidence incidence NN cord-010119-t1x9gknd 2563 15 of of IN cord-010119-t1x9gknd 2563 16 BCPTR BCPTR NNP cord-010119-t1x9gknd 2563 17 ; ; : cord-010119-t1x9gknd 2563 18 the the DT cord-010119-t1x9gknd 2563 19 severity severity NN cord-010119-t1x9gknd 2563 20 and and CC cord-010119-t1x9gknd 2563 21 symptoms symptom NNS cord-010119-t1x9gknd 2563 22 were be VBD cord-010119-t1x9gknd 2563 23 evaluated evaluate VBN cord-010119-t1x9gknd 2563 24 in in IN cord-010119-t1x9gknd 2563 25 concordance concordance NN cord-010119-t1x9gknd 2563 26 with with IN cord-010119-t1x9gknd 2563 27 recipient recipient NN cord-010119-t1x9gknd 2563 28 data datum NNS cord-010119-t1x9gknd 2563 29 , , , cord-010119-t1x9gknd 2563 30 including include VBG cord-010119-t1x9gknd 2563 31 patient patient JJ cord-010119-t1x9gknd 2563 32 diagnosis diagnosis NN cord-010119-t1x9gknd 2563 33 , , , cord-010119-t1x9gknd 2563 34 medications medication NNS cord-010119-t1x9gknd 2563 35 and and CC cord-010119-t1x9gknd 2563 36 clinical clinical JJ cord-010119-t1x9gknd 2563 37 manifestations manifestation NNS cord-010119-t1x9gknd 2563 38 of of IN cord-010119-t1x9gknd 2563 39 the the DT cord-010119-t1x9gknd 2563 40 reaction reaction NN cord-010119-t1x9gknd 2563 41 . . . cord-010119-t1x9gknd 2564 1 Bacterial bacterial JJ cord-010119-t1x9gknd 2564 2 culture culture NN cord-010119-t1x9gknd 2564 3 results result NNS cord-010119-t1x9gknd 2564 4 were be VBD cord-010119-t1x9gknd 2564 5 evaluated evaluate VBN cord-010119-t1x9gknd 2564 6 for for IN cord-010119-t1x9gknd 2564 7 both both DT cord-010119-t1x9gknd 2564 8 patients patient NNS cord-010119-t1x9gknd 2564 9 and and CC cord-010119-t1x9gknd 2564 10 associated associate VBD cord-010119-t1x9gknd 2564 11 blood blood NN cord-010119-t1x9gknd 2564 12 products product NNS cord-010119-t1x9gknd 2564 13 ( ( -LRB- cord-010119-t1x9gknd 2564 14 i.e. i.e. FW cord-010119-t1x9gknd 2564 15 partially partially RB cord-010119-t1x9gknd 2564 16 transfused transfuse VBN cord-010119-t1x9gknd 2564 17 or or CC cord-010119-t1x9gknd 2564 18 residual residual JJ cord-010119-t1x9gknd 2564 19 product product NN cord-010119-t1x9gknd 2564 20 in in IN cord-010119-t1x9gknd 2564 21 blood blood NN cord-010119-t1x9gknd 2564 22 bag bag NN cord-010119-t1x9gknd 2564 23 ) ) -RRB- cord-010119-t1x9gknd 2564 24 . . . cord-010119-t1x9gknd 2565 1 Results/ Results/ . cord-010119-t1x9gknd 2566 1 Finding finding NN cord-010119-t1x9gknd 2566 2 : : : cord-010119-t1x9gknd 2567 1 In in IN cord-010119-t1x9gknd 2567 2 the the DT cord-010119-t1x9gknd 2567 3 7-year 7-year JJ cord-010119-t1x9gknd 2567 4 study study NN cord-010119-t1x9gknd 2567 5 period period NN cord-010119-t1x9gknd 2567 6 , , , cord-010119-t1x9gknd 2567 7 a a DT cord-010119-t1x9gknd 2567 8 total total NN cord-010119-t1x9gknd 2567 9 of of IN cord-010119-t1x9gknd 2567 10 3280 3280 CD cord-010119-t1x9gknd 2567 11 transfusions transfusion NNS cord-010119-t1x9gknd 2567 12 reactions reaction NNS cord-010119-t1x9gknd 2567 13 were be VBD cord-010119-t1x9gknd 2567 14 reported report VBN cord-010119-t1x9gknd 2567 15 , , , cord-010119-t1x9gknd 2567 16 18 18 CD cord-010119-t1x9gknd 2567 17 of of IN cord-010119-t1x9gknd 2567 18 which which WDT cord-010119-t1x9gknd 2567 19 were be VBD cord-010119-t1x9gknd 2567 20 BCPTR BCPTR NNP cord-010119-t1x9gknd 2567 21 ( ( -LRB- cord-010119-t1x9gknd 2567 22 0.55 0.55 CD cord-010119-t1x9gknd 2567 23 % % NN cord-010119-t1x9gknd 2567 24 of of IN cord-010119-t1x9gknd 2567 25 transfusion transfusion NN cord-010119-t1x9gknd 2567 26 reactions reaction NNS cord-010119-t1x9gknd 2567 27 ) ) -RRB- cord-010119-t1x9gknd 2567 28 . . . cord-010119-t1x9gknd 2568 1 Of of IN cord-010119-t1x9gknd 2568 2 the the DT cord-010119-t1x9gknd 2568 3 18 18 CD cord-010119-t1x9gknd 2568 4 BCPTR BCPTR NNP cord-010119-t1x9gknd 2568 5 , , , cord-010119-t1x9gknd 2568 6 15 15 CD cord-010119-t1x9gknd 2568 7 ( ( -LRB- cord-010119-t1x9gknd 2568 8 83 83 CD cord-010119-t1x9gknd 2568 9 % % NN cord-010119-t1x9gknd 2568 10 ) ) -RRB- cord-010119-t1x9gknd 2568 11 were be VBD cord-010119-t1x9gknd 2568 12 associated associate VBN cord-010119-t1x9gknd 2568 13 with with IN cord-010119-t1x9gknd 2568 14 apheresis apheresis NN cord-010119-t1x9gknd 2568 15 platelets platelet NNS cord-010119-t1x9gknd 2568 16 , , , cord-010119-t1x9gknd 2568 17 2 2 CD cord-010119-t1x9gknd 2568 18 ( ( -LRB- cord-010119-t1x9gknd 2568 19 11 11 CD cord-010119-t1x9gknd 2568 20 % % NN cord-010119-t1x9gknd 2568 21 ) ) -RRB- cord-010119-t1x9gknd 2568 22 with with IN cord-010119-t1x9gknd 2568 23 red red JJ cord-010119-t1x9gknd 2568 24 blood blood NN cord-010119-t1x9gknd 2568 25 cells cell NNS cord-010119-t1x9gknd 2568 26 , , , cord-010119-t1x9gknd 2568 27 and and CC cord-010119-t1x9gknd 2568 28 1 1 CD cord-010119-t1x9gknd 2568 29 ( ( -LRB- cord-010119-t1x9gknd 2568 30 6 6 CD cord-010119-t1x9gknd 2568 31 % % NN cord-010119-t1x9gknd 2568 32 ) ) -RRB- cord-010119-t1x9gknd 2568 33 with with IN cord-010119-t1x9gknd 2568 34 plasma plasma NN cord-010119-t1x9gknd 2568 35 . . . cord-010119-t1x9gknd 2569 1 Recipient recipient NN cord-010119-t1x9gknd 2569 2 diagnoses diagnosis NNS cord-010119-t1x9gknd 2569 3 spanned span VBD cord-010119-t1x9gknd 2569 4 hematologic hematologic JJ cord-010119-t1x9gknd 2569 5 / / SYM cord-010119-t1x9gknd 2569 6 oncology oncology NN cord-010119-t1x9gknd 2569 7 ( ( -LRB- cord-010119-t1x9gknd 2569 8 n512 n512 NNP cord-010119-t1x9gknd 2569 9 ) ) -RRB- cord-010119-t1x9gknd 2569 10 , , , cord-010119-t1x9gknd 2569 11 renal renal JJ cord-010119-t1x9gknd 2569 12 ( ( -LRB- cord-010119-t1x9gknd 2569 13 n53 n53 NN cord-010119-t1x9gknd 2569 14 ) ) -RRB- cord-010119-t1x9gknd 2569 15 , , , cord-010119-t1x9gknd 2569 16 cardiac cardiac NNP cord-010119-t1x9gknd 2569 17 ( ( -LRB- cord-010119-t1x9gknd 2569 18 n51 n51 NNP cord-010119-t1x9gknd 2569 19 ) ) -RRB- cord-010119-t1x9gknd 2569 20 , , , cord-010119-t1x9gknd 2569 21 autoimmune autoimmune NNP cord-010119-t1x9gknd 2569 22 ( ( -LRB- cord-010119-t1x9gknd 2569 23 n51 n51 NNP cord-010119-t1x9gknd 2569 24 ) ) -RRB- cord-010119-t1x9gknd 2569 25 , , , cord-010119-t1x9gknd 2569 26 and and CC cord-010119-t1x9gknd 2569 27 obstetrics obstetric NNS cord-010119-t1x9gknd 2569 28 ( ( -LRB- cord-010119-t1x9gknd 2569 29 n51 n51 NNP cord-010119-t1x9gknd 2569 30 ) ) -RRB- cord-010119-t1x9gknd 2569 31 . . . cord-010119-t1x9gknd 2570 1 An an DT cord-010119-t1x9gknd 2570 2 organism organism NN cord-010119-t1x9gknd 2570 3 was be VBD cord-010119-t1x9gknd 2570 4 identified identify VBN cord-010119-t1x9gknd 2570 5 in in IN cord-010119-t1x9gknd 2570 6 both both CC cord-010119-t1x9gknd 2570 7 the the DT cord-010119-t1x9gknd 2570 8 blood blood NN cord-010119-t1x9gknd 2570 9 product product NN cord-010119-t1x9gknd 2570 10 and and CC cord-010119-t1x9gknd 2570 11 recipient recipient NN cord-010119-t1x9gknd 2570 12 in in IN cord-010119-t1x9gknd 2570 13 10 10 CD cord-010119-t1x9gknd 2570 14 ( ( -LRB- cord-010119-t1x9gknd 2570 15 56 56 CD cord-010119-t1x9gknd 2570 16 % % NN cord-010119-t1x9gknd 2570 17 ) ) -RRB- cord-010119-t1x9gknd 2570 18 cases case NNS cord-010119-t1x9gknd 2570 19 ; ; : cord-010119-t1x9gknd 2570 20 in in IN cord-010119-t1x9gknd 2570 21 6 6 CD cord-010119-t1x9gknd 2570 22 ( ( -LRB- cord-010119-t1x9gknd 2570 23 33 33 CD cord-010119-t1x9gknd 2570 24 % % NN cord-010119-t1x9gknd 2570 25 ) ) -RRB- cord-010119-t1x9gknd 2570 26 cases case VBZ cord-010119-t1x9gknd 2570 27 an an DT cord-010119-t1x9gknd 2570 28 organism organism NN cord-010119-t1x9gknd 2570 29 was be VBD cord-010119-t1x9gknd 2570 30 grown grow VBN cord-010119-t1x9gknd 2570 31 in in IN cord-010119-t1x9gknd 2570 32 the the DT cord-010119-t1x9gknd 2570 33 blood blood NN cord-010119-t1x9gknd 2570 34 product product NN cord-010119-t1x9gknd 2570 35 but but CC cord-010119-t1x9gknd 2570 36 not not RB cord-010119-t1x9gknd 2570 37 the the DT cord-010119-t1x9gknd 2570 38 recipient recipient NN cord-010119-t1x9gknd 2570 39 ; ; : cord-010119-t1x9gknd 2570 40 and and CC cord-010119-t1x9gknd 2570 41 in in IN cord-010119-t1x9gknd 2570 42 2 2 CD cord-010119-t1x9gknd 2570 43 ( ( -LRB- cord-010119-t1x9gknd 2570 44 11 11 CD cord-010119-t1x9gknd 2570 45 % % NN cord-010119-t1x9gknd 2570 46 ) ) -RRB- cord-010119-t1x9gknd 2570 47 cases case VBZ cord-010119-t1x9gknd 2570 48 an an DT cord-010119-t1x9gknd 2570 49 organism organism NN cord-010119-t1x9gknd 2570 50 was be VBD cord-010119-t1x9gknd 2570 51 isolated isolate VBN cord-010119-t1x9gknd 2570 52 from from IN cord-010119-t1x9gknd 2570 53 the the DT cord-010119-t1x9gknd 2570 54 recipient recipient NN cord-010119-t1x9gknd 2570 55 only only RB cord-010119-t1x9gknd 2570 56 , , , cord-010119-t1x9gknd 2570 57 due due IN cord-010119-t1x9gknd 2570 58 to to IN cord-010119-t1x9gknd 2570 59 inability inability NN cord-010119-t1x9gknd 2570 60 to to TO cord-010119-t1x9gknd 2570 61 culture culture VB cord-010119-t1x9gknd 2570 62 the the DT cord-010119-t1x9gknd 2570 63 product product NN cord-010119-t1x9gknd 2570 64 . . . cord-010119-t1x9gknd 2571 1 The the DT cord-010119-t1x9gknd 2571 2 transfusion transfusion NN cord-010119-t1x9gknd 2571 3 recipients recipient NNS cord-010119-t1x9gknd 2571 4 in in IN cord-010119-t1x9gknd 2571 5 5 5 CD cord-010119-t1x9gknd 2571 6 of of IN cord-010119-t1x9gknd 2571 7 the the DT cord-010119-t1x9gknd 2571 8 6 6 CD cord-010119-t1x9gknd 2571 9 cases case NNS cord-010119-t1x9gknd 2571 10 that that WDT cord-010119-t1x9gknd 2571 11 did do VBD cord-010119-t1x9gknd 2571 12 not not RB cord-010119-t1x9gknd 2571 13 isolate isolate VB cord-010119-t1x9gknd 2571 14 organisms organism NNS cord-010119-t1x9gknd 2571 15 in in IN cord-010119-t1x9gknd 2571 16 the the DT cord-010119-t1x9gknd 2571 17 recipients recipient NNS cord-010119-t1x9gknd 2571 18 were be VBD cord-010119-t1x9gknd 2571 19 on on IN cord-010119-t1x9gknd 2571 20 broad broad JJ cord-010119-t1x9gknd 2571 21 - - HYPH cord-010119-t1x9gknd 2571 22 spectrum spectrum NN cord-010119-t1x9gknd 2571 23 antibiotics antibiotic NNS cord-010119-t1x9gknd 2571 24 at at IN cord-010119-t1x9gknd 2571 25 the the DT cord-010119-t1x9gknd 2571 26 time time NN cord-010119-t1x9gknd 2571 27 of of IN cord-010119-t1x9gknd 2571 28 transfusion transfusion NN cord-010119-t1x9gknd 2571 29 . . . cord-010119-t1x9gknd 2572 1 Symptoms symptom NNS cord-010119-t1x9gknd 2572 2 of of IN cord-010119-t1x9gknd 2572 3 BCPTRs bcptr NNS cord-010119-t1x9gknd 2572 4 included include VBD cord-010119-t1x9gknd 2572 5 fever fever NN cord-010119-t1x9gknd 2572 6 ( ( -LRB- cord-010119-t1x9gknd 2572 7 83 83 CD cord-010119-t1x9gknd 2572 8 % % NN cord-010119-t1x9gknd 2572 9 ) ) -RRB- cord-010119-t1x9gknd 2572 10 , , , cord-010119-t1x9gknd 2572 11 chills chill NNS cord-010119-t1x9gknd 2572 12 ( ( -LRB- cord-010119-t1x9gknd 2572 13 67 67 CD cord-010119-t1x9gknd 2572 14 % % NN cord-010119-t1x9gknd 2572 15 ) ) -RRB- cord-010119-t1x9gknd 2572 16 , , , cord-010119-t1x9gknd 2572 17 nausea nausea NN cord-010119-t1x9gknd 2572 18 and and CC cord-010119-t1x9gknd 2572 19 vomiting vomiting NN cord-010119-t1x9gknd 2572 20 ( ( -LRB- cord-010119-t1x9gknd 2572 21 50 50 CD cord-010119-t1x9gknd 2572 22 % % NN cord-010119-t1x9gknd 2572 23 ) ) -RRB- cord-010119-t1x9gknd 2572 24 , , , cord-010119-t1x9gknd 2572 25 pain pain NN cord-010119-t1x9gknd 2572 26 ( ( -LRB- cord-010119-t1x9gknd 2572 27 27 27 CD cord-010119-t1x9gknd 2572 28 % % NN cord-010119-t1x9gknd 2572 29 ) ) -RRB- cord-010119-t1x9gknd 2572 30 and and CC cord-010119-t1x9gknd 2572 31 dyspnea dyspnea NN cord-010119-t1x9gknd 2572 32 ( ( -LRB- cord-010119-t1x9gknd 2572 33 22 22 CD cord-010119-t1x9gknd 2572 34 % % NN cord-010119-t1x9gknd 2572 35 ) ) -RRB- cord-010119-t1x9gknd 2572 36 . . . cord-010119-t1x9gknd 2573 1 Blood blood NN cord-010119-t1x9gknd 2573 2 pressure pressure NN cord-010119-t1x9gknd 2573 3 ( ( -LRB- cord-010119-t1x9gknd 2573 4 BP BP NNP cord-010119-t1x9gknd 2573 5 ) ) -RRB- cord-010119-t1x9gknd 2573 6 decreased decrease VBD cord-010119-t1x9gknd 2573 7 in in IN cord-010119-t1x9gknd 2573 8 22 22 CD cord-010119-t1x9gknd 2573 9 % % NN cord-010119-t1x9gknd 2573 10 , , , cord-010119-t1x9gknd 2573 11 increased increase VBD cord-010119-t1x9gknd 2573 12 in in IN cord-010119-t1x9gknd 2573 13 17 17 CD cord-010119-t1x9gknd 2573 14 % % NN cord-010119-t1x9gknd 2573 15 ; ; : cord-010119-t1x9gknd 2573 16 61 61 CD cord-010119-t1x9gknd 2573 17 % % NN cord-010119-t1x9gknd 2573 18 of of IN cord-010119-t1x9gknd 2573 19 reported report VBN cord-010119-t1x9gknd 2573 20 BCPTRs bcptr NNS cord-010119-t1x9gknd 2573 21 had have VBD cord-010119-t1x9gknd 2573 22 no no DT cord-010119-t1x9gknd 2573 23 change change NN cord-010119-t1x9gknd 2573 24 in in IN cord-010119-t1x9gknd 2573 25 BP BP NNP cord-010119-t1x9gknd 2573 26 . . . cord-010119-t1x9gknd 2574 1 Conclusion conclusion NN cord-010119-t1x9gknd 2574 2 : : : cord-010119-t1x9gknd 2575 1 The the DT cord-010119-t1x9gknd 2575 2 signs sign NNS cord-010119-t1x9gknd 2575 3 and and CC cord-010119-t1x9gknd 2575 4 symptoms symptom NNS cord-010119-t1x9gknd 2575 5 of of IN cord-010119-t1x9gknd 2575 6 BCPTRs bcptr NNS cord-010119-t1x9gknd 2575 7 are be VBP cord-010119-t1x9gknd 2575 8 not not RB cord-010119-t1x9gknd 2575 9 specific specific JJ cord-010119-t1x9gknd 2575 10 and and CC cord-010119-t1x9gknd 2575 11 overlap overlap VBP cord-010119-t1x9gknd 2575 12 both both DT cord-010119-t1x9gknd 2575 13 with with IN cord-010119-t1x9gknd 2575 14 underlying underlying JJ cord-010119-t1x9gknd 2575 15 disease disease NN cord-010119-t1x9gknd 2575 16 as as RB cord-010119-t1x9gknd 2575 17 well well RB cord-010119-t1x9gknd 2575 18 as as IN cord-010119-t1x9gknd 2575 19 other other JJ cord-010119-t1x9gknd 2575 20 types type NNS cord-010119-t1x9gknd 2575 21 of of IN cord-010119-t1x9gknd 2575 22 adverse adverse JJ cord-010119-t1x9gknd 2575 23 transfusion transfusion NN cord-010119-t1x9gknd 2575 24 associated associate VBD cord-010119-t1x9gknd 2575 25 events event NNS cord-010119-t1x9gknd 2575 26 , , , cord-010119-t1x9gknd 2575 27 thus thus RB cord-010119-t1x9gknd 2575 28 contributing contribute VBG cord-010119-t1x9gknd 2575 29 to to IN cord-010119-t1x9gknd 2575 30 delayed delay VBN cord-010119-t1x9gknd 2575 31 diagnosis diagnosis NN cord-010119-t1x9gknd 2575 32 and and CC cord-010119-t1x9gknd 2575 33 under under IN cord-010119-t1x9gknd 2575 34 - - HYPH cord-010119-t1x9gknd 2575 35 reporting reporting NN cord-010119-t1x9gknd 2575 36 . . . cord-010119-t1x9gknd 2576 1 Furthermore furthermore RB cord-010119-t1x9gknd 2576 2 , , , cord-010119-t1x9gknd 2576 3 high high JJ cord-010119-t1x9gknd 2576 4 rates rate NNS cord-010119-t1x9gknd 2576 5 of of IN cord-010119-t1x9gknd 2576 6 antibiotic antibiotic JJ cord-010119-t1x9gknd 2576 7 use use NN cord-010119-t1x9gknd 2576 8 in in IN cord-010119-t1x9gknd 2576 9 transfusion transfusion NN cord-010119-t1x9gknd 2576 10 recipients recipient NNS cord-010119-t1x9gknd 2576 11 can can MD cord-010119-t1x9gknd 2576 12 mask mask VB cord-010119-t1x9gknd 2576 13 symptoms symptom NNS cord-010119-t1x9gknd 2576 14 of of IN cord-010119-t1x9gknd 2576 15 true true JJ cord-010119-t1x9gknd 2576 16 septic septic JJ cord-010119-t1x9gknd 2576 17 transfusion transfusion NN cord-010119-t1x9gknd 2576 18 reactions reaction NNS cord-010119-t1x9gknd 2576 19 . . . cord-010119-t1x9gknd 2577 1 Hospitals hospital NNS cord-010119-t1x9gknd 2577 2 should should MD cord-010119-t1x9gknd 2577 3 consider consider VB cord-010119-t1x9gknd 2577 4 expanding expand VBG cord-010119-t1x9gknd 2577 5 the the DT cord-010119-t1x9gknd 2577 6 clinical clinical JJ cord-010119-t1x9gknd 2577 7 indications indication NNS cord-010119-t1x9gknd 2577 8 for for IN cord-010119-t1x9gknd 2577 9 culturing culture VBG cord-010119-t1x9gknd 2577 10 blood blood NN cord-010119-t1x9gknd 2577 11 components component NNS cord-010119-t1x9gknd 2577 12 that that WDT cord-010119-t1x9gknd 2577 13 are be VBP cord-010119-t1x9gknd 2577 14 implicated implicate VBN cord-010119-t1x9gknd 2577 15 in in IN cord-010119-t1x9gknd 2577 16 transfusion transfusion NN cord-010119-t1x9gknd 2577 17 reactions reaction NNS cord-010119-t1x9gknd 2577 18 . . . cord-010119-t1x9gknd 2578 1 Furthermore furthermore RB cord-010119-t1x9gknd 2578 2 , , , cord-010119-t1x9gknd 2578 3 excessively excessively RB cord-010119-t1x9gknd 2578 4 stringent stringent JJ cord-010119-t1x9gknd 2578 5 criteria criterion NNS cord-010119-t1x9gknd 2578 6 ( ( -LRB- cord-010119-t1x9gknd 2578 7 CDC CDC NNP cord-010119-t1x9gknd 2578 8 / / SYM cord-010119-t1x9gknd 2578 9 NHSN NHSN NNP cord-010119-t1x9gknd 2578 10 Blood Blood NNP cord-010119-t1x9gknd 2578 11 Safety Safety NNP cord-010119-t1x9gknd 2578 12 Surveillance Surveillance NNP cord-010119-t1x9gknd 2578 13 ) ) -RRB- cord-010119-t1x9gknd 2578 14 for for IN cord-010119-t1x9gknd 2578 15 transfusion transfusion NN cord-010119-t1x9gknd 2578 16 - - HYPH cord-010119-t1x9gknd 2578 17 transmitted transmit VBN cord-010119-t1x9gknd 2578 18 infection infection NN cord-010119-t1x9gknd 2578 19 , , , cord-010119-t1x9gknd 2578 20 may may MD cord-010119-t1x9gknd 2578 21 contribute contribute VB cord-010119-t1x9gknd 2578 22 to to IN cord-010119-t1x9gknd 2578 23 misclassification misclassification NN cord-010119-t1x9gknd 2578 24 of of IN cord-010119-t1x9gknd 2578 25 septic septic JJ cord-010119-t1x9gknd 2578 26 events event NNS cord-010119-t1x9gknd 2578 27 in in IN cord-010119-t1x9gknd 2578 28 some some DT cord-010119-t1x9gknd 2578 29 recipients recipient NNS cord-010119-t1x9gknd 2578 30 , , , cord-010119-t1x9gknd 2578 31 particularly particularly RB cord-010119-t1x9gknd 2578 32 if if IN cord-010119-t1x9gknd 2578 33 on on IN cord-010119-t1x9gknd 2578 34 antibiotics antibiotic NNS cord-010119-t1x9gknd 2578 35 . . . cord-010119-t1x9gknd 2579 1 Clinical clinical JJ cord-010119-t1x9gknd 2579 2 Oral Oral NNP cord-010119-t1x9gknd 2579 3 Abstract Abstract NNP cord-010119-t1x9gknd 2579 4 Session session NN cord-010119-t1x9gknd 2579 5 : : : cord-010119-t1x9gknd 2580 1 Immonohematology Immonohematology NNP cord-010119-t1x9gknd 2580 2 and and CC cord-010119-t1x9gknd 2580 3 Genetics Genetics NNP cord-010119-t1x9gknd 2580 4 --Sickle --Sickle VBZ cord-010119-t1x9gknd 2580 5 Cell Cell NNP cord-010119-t1x9gknd 2580 6 Disease Disease NNP cord-010119-t1x9gknd 2580 7 and and CC cord-010119-t1x9gknd 2580 8 Beyond Beyond NNP cord-010119-t1x9gknd 2580 9 Blindspots Blindspots NNP cord-010119-t1x9gknd 2580 10 and and CC cord-010119-t1x9gknd 2580 11 Cross Cross NNP cord-010119-t1x9gknd 2580 12 - - HYPH cord-010119-t1x9gknd 2580 13 Reactivities Reactivities NNP cord-010119-t1x9gknd 2580 14 of of IN cord-010119-t1x9gknd 2580 15 Anti Anti NNP cord-010119-t1x9gknd 2580 16 - - NNP cord-010119-t1x9gknd 2580 17 Human human JJ cord-010119-t1x9gknd 2580 18 Globulin Globulin NNP cord-010119-t1x9gknd 2580 19 Specific Specific NNP cord-010119-t1x9gknd 2580 20 for for IN cord-010119-t1x9gknd 2580 21 IgG igg NN cord-010119-t1x9gknd 2580 22 Subtypes subtype NNS cord-010119-t1x9gknd 2581 1 Heather Heather NNP cord-010119-t1x9gknd 2581 2 Howie Howie NNP cord-010119-t1x9gknd 2581 3 1 1 CD cord-010119-t1x9gknd 2581 4 , , , cord-010119-t1x9gknd 2581 5 Jenna Jenna NNP cord-010119-t1x9gknd 2581 6 Lebedev Lebedev NNP cord-010119-t1x9gknd 2581 7 1 1 CD cord-010119-t1x9gknd 2581 8 , , , cord-010119-t1x9gknd 2581 9 Linda Linda NNP cord-010119-t1x9gknd 2581 10 Kapp Kapp NNP cord-010119-t1x9gknd 2581 11 1 1 CD cord-010119-t1x9gknd 2581 12 , , , cord-010119-t1x9gknd 2582 1 Xiaohong Xiaohong NNP cord-010119-t1x9gknd 2582 2 Wang Wang NNP cord-010119-t1x9gknd 2582 3 1 1 CD cord-010119-t1x9gknd 2582 4 , , , cord-010119-t1x9gknd 2582 5 Meghan Meghan NNP cord-010119-t1x9gknd 2582 6 Delaney Delaney NNP cord-010119-t1x9gknd 2582 7 2 2 CD cord-010119-t1x9gknd 2583 1 , , , cord-010119-t1x9gknd 2583 2 Lay Lay NNP cord-010119-t1x9gknd 2583 3 See See NNP cord-010119-t1x9gknd 2583 4 Er Er NNP cord-010119-t1x9gknd 2583 5 1 1 CD cord-010119-t1x9gknd 2583 6 and and CC cord-010119-t1x9gknd 2584 1 James James NNP cord-010119-t1x9gknd 2584 2 C C NNP cord-010119-t1x9gknd 2584 3 Zimring Zimring NNP cord-010119-t1x9gknd 2584 4 * * NFP cord-010119-t1x9gknd 2584 5 3 3 CD cord-010119-t1x9gknd 2584 6 . . NN cord-010119-t1x9gknd 2584 7 1 1 CD cord-010119-t1x9gknd 2584 8 BloodworksNW BloodworksNW NNP cord-010119-t1x9gknd 2584 9 Research Research NNP cord-010119-t1x9gknd 2584 10 Institute Institute NNP cord-010119-t1x9gknd 2584 11 , , , cord-010119-t1x9gknd 2584 12 2 2 CD cord-010119-t1x9gknd 2584 13 Bloodworks Bloodworks NNP cord-010119-t1x9gknd 2584 14 NW NW NNP cord-010119-t1x9gknd 2584 15 , , , cord-010119-t1x9gknd 2584 16 3 3 CD cord-010119-t1x9gknd 2584 17 University University NNP cord-010119-t1x9gknd 2584 18 of of IN cord-010119-t1x9gknd 2584 19 Washington Washington NNP cord-010119-t1x9gknd 2584 20 School School NNP cord-010119-t1x9gknd 2584 21 of of IN cord-010119-t1x9gknd 2584 22 Medicine Medicine NNP cord-010119-t1x9gknd 2584 23 Background Background NNP cord-010119-t1x9gknd 2584 24 / / SYM cord-010119-t1x9gknd 2584 25 Case Case NNP cord-010119-t1x9gknd 2584 26 Studies Studies NNPS cord-010119-t1x9gknd 2585 1 : : : cord-010119-t1x9gknd 2585 2 There there EX cord-010119-t1x9gknd 2585 3 are be VBP cord-010119-t1x9gknd 2585 4 four four CD cord-010119-t1x9gknd 2585 5 different different JJ cord-010119-t1x9gknd 2585 6 subclasses subclass NNS cord-010119-t1x9gknd 2585 7 of of IN cord-010119-t1x9gknd 2585 8 human human JJ cord-010119-t1x9gknd 2585 9 IgG igg NN cord-010119-t1x9gknd 2585 10 ( ( -LRB- cord-010119-t1x9gknd 2585 11 IgG1-IgG4 IgG1-IgG4 NNP cord-010119-t1x9gknd 2585 12 ) ) -RRB- cord-010119-t1x9gknd 2585 13 , , , cord-010119-t1x9gknd 2585 14 each each DT cord-010119-t1x9gknd 2585 15 with with IN cord-010119-t1x9gknd 2585 16 different different JJ cord-010119-t1x9gknd 2585 17 effector effector NN cord-010119-t1x9gknd 2585 18 function function NN cord-010119-t1x9gknd 2585 19 . . . cord-010119-t1x9gknd 2586 1 Essentially essentially RB cord-010119-t1x9gknd 2586 2 all all DT cord-010119-t1x9gknd 2586 3 existing exist VBG cord-010119-t1x9gknd 2586 4 data datum NNS cord-010119-t1x9gknd 2586 5 on on IN cord-010119-t1x9gknd 2586 6 the the DT cord-010119-t1x9gknd 2586 7 effect effect NN cord-010119-t1x9gknd 2586 8 of of IN cord-010119-t1x9gknd 2586 9 IgG igg NN cord-010119-t1x9gknd 2586 10 subclass subclass NN cord-010119-t1x9gknd 2586 11 on on IN cord-010119-t1x9gknd 2586 12 hemolytic hemolytic JJ cord-010119-t1x9gknd 2586 13 transfusion transfusion NN cord-010119-t1x9gknd 2586 14 reactions reaction NNS cord-010119-t1x9gknd 2586 15 and and CC cord-010119-t1x9gknd 2586 16 HDFN HDFN NNP cord-010119-t1x9gknd 2586 17 , , , cord-010119-t1x9gknd 2586 18 were be VBD cord-010119-t1x9gknd 2586 19 generated generate VBN cord-010119-t1x9gknd 2586 20 using use VBG cord-010119-t1x9gknd 2586 21 AHG AHG NNP cord-010119-t1x9gknd 2586 22 specific specific JJ cord-010119-t1x9gknd 2586 23 for for IN cord-010119-t1x9gknd 2586 24 IgG IgG NNP cord-010119-t1x9gknd 2586 25 subclasses subclass NNS cord-010119-t1x9gknd 2586 26 . . . cord-010119-t1x9gknd 2587 1 In in IN cord-010119-t1x9gknd 2587 2 recent recent JJ cord-010119-t1x9gknd 2587 3 decades decade NNS cord-010119-t1x9gknd 2587 4 , , , cord-010119-t1x9gknd 2587 5 it -PRON- PRP cord-010119-t1x9gknd 2587 6 has have VBZ cord-010119-t1x9gknd 2587 7 become become VBN cord-010119-t1x9gknd 2587 8 appreciated appreciate VBN cord-010119-t1x9gknd 2587 9 that that IN cord-010119-t1x9gknd 2587 10 there there EX cord-010119-t1x9gknd 2587 11 are be VBP cord-010119-t1x9gknd 2587 12 at at RB cord-010119-t1x9gknd 2587 13 least least RBS cord-010119-t1x9gknd 2587 14 29 29 CD cord-010119-t1x9gknd 2587 15 natural natural JJ cord-010119-t1x9gknd 2587 16 human human JJ cord-010119-t1x9gknd 2587 17 variants variant NNS cord-010119-t1x9gknd 2587 18 of of IN cord-010119-t1x9gknd 2587 19 IgG. IgG. NNP cord-010119-t1x9gknd 2588 1 In in IN cord-010119-t1x9gknd 2588 2 this this DT cord-010119-t1x9gknd 2588 3 study study NN cord-010119-t1x9gknd 2588 4 , , , cord-010119-t1x9gknd 2588 5 the the DT cord-010119-t1x9gknd 2588 6 reactivity reactivity NN cord-010119-t1x9gknd 2588 7 of of IN cord-010119-t1x9gknd 2588 8 IgG IgG NNP cord-010119-t1x9gknd 2588 9 specific specific JJ cord-010119-t1x9gknd 2588 10 AHG AHG NNP cord-010119-t1x9gknd 2588 11 was be VBD cord-010119-t1x9gknd 2588 12 tested test VBN cord-010119-t1x9gknd 2588 13 against against IN cord-010119-t1x9gknd 2588 14 all all DT cord-010119-t1x9gknd 2588 15 29 29 CD cord-010119-t1x9gknd 2588 16 known know VBN cord-010119-t1x9gknd 2588 17 variants variant NNS cord-010119-t1x9gknd 2588 18 . . . cord-010119-t1x9gknd 2589 1 Study Study NNP cord-010119-t1x9gknd 2589 2 Design Design NNP cord-010119-t1x9gknd 2589 3 / / SYM cord-010119-t1x9gknd 2589 4 Methods method NNS cord-010119-t1x9gknd 2589 5 : : : cord-010119-t1x9gknd 2589 6 The the DT cord-010119-t1x9gknd 2589 7 heavy heavy JJ cord-010119-t1x9gknd 2589 8 and and CC cord-010119-t1x9gknd 2589 9 light light JJ cord-010119-t1x9gknd 2589 10 chain chain NN cord-010119-t1x9gknd 2589 11 variable variable NN cord-010119-t1x9gknd 2589 12 regions region NNS cord-010119-t1x9gknd 2589 13 of of IN cord-010119-t1x9gknd 2589 14 an an DT cord-010119-t1x9gknd 2589 15 anti anti JJ cord-010119-t1x9gknd 2589 16 - - JJ cord-010119-t1x9gknd 2589 17 K1 k1 JJ cord-010119-t1x9gknd 2589 18 monoclonal monoclonal JJ cord-010119-t1x9gknd 2589 19 antibody antibody NN cord-010119-t1x9gknd 2589 20 were be VBD cord-010119-t1x9gknd 2589 21 sequenced sequence VBN cord-010119-t1x9gknd 2589 22 and and CC cord-010119-t1x9gknd 2589 23 cloned clone VBN cord-010119-t1x9gknd 2589 24 into into IN cord-010119-t1x9gknd 2589 25 expression expression NN cord-010119-t1x9gknd 2589 26 plasmids plasmid NNS cord-010119-t1x9gknd 2589 27 that that WDT cord-010119-t1x9gknd 2589 28 fused fuse VBD cord-010119-t1x9gknd 2589 29 variable variable JJ cord-010119-t1x9gknd 2589 30 regions region NNS cord-010119-t1x9gknd 2589 31 ( ( -LRB- cord-010119-t1x9gknd 2589 32 in in IN cord-010119-t1x9gknd 2589 33 frame frame NN cord-010119-t1x9gknd 2589 34 ) ) -RRB- cord-010119-t1x9gknd 2589 35 with with IN cord-010119-t1x9gknd 2589 36 each each DT cord-010119-t1x9gknd 2589 37 of of IN cord-010119-t1x9gknd 2589 38 the the DT cord-010119-t1x9gknd 2589 39 known know VBN cord-010119-t1x9gknd 2589 40 29 29 CD cord-010119-t1x9gknd 2589 41 IgG igg NN cord-010119-t1x9gknd 2589 42 variants variant NNS cord-010119-t1x9gknd 2589 43 . . . cord-010119-t1x9gknd 2590 1 Plasmids plasmid NNS cord-010119-t1x9gknd 2590 2 were be VBD cord-010119-t1x9gknd 2590 3 expressed express VBN cord-010119-t1x9gknd 2590 4 by by IN cord-010119-t1x9gknd 2590 5 co co NN cord-010119-t1x9gknd 2590 6 - - NN cord-010119-t1x9gknd 2590 7 transfection transfection NN cord-010119-t1x9gknd 2590 8 into into IN cord-010119-t1x9gknd 2590 9 CHO CHO NNP cord-010119-t1x9gknd 2590 10 cells cell NNS cord-010119-t1x9gknd 2590 11 . . . cord-010119-t1x9gknd 2591 1 The the DT cord-010119-t1x9gknd 2591 2 resulting result VBG cord-010119-t1x9gknd 2591 3 panel panel NN cord-010119-t1x9gknd 2591 4 of of IN cord-010119-t1x9gknd 2591 5 antibodies antibody NNS cord-010119-t1x9gknd 2591 6 were be VBD cord-010119-t1x9gknd 2591 7 pre pre VBN cord-010119-t1x9gknd 2591 8 - - VBN cord-010119-t1x9gknd 2591 9 incubated incubate VBN cord-010119-t1x9gknd 2591 10 with with IN cord-010119-t1x9gknd 2591 11 K11 K11 NNP cord-010119-t1x9gknd 2591 12 RBCs rbc NNS cord-010119-t1x9gknd 2591 13 and and CC cord-010119-t1x9gknd 2591 14 were be VBD cord-010119-t1x9gknd 2591 15 then then RB cord-010119-t1x9gknd 2591 16 subjected subject VBN cord-010119-t1x9gknd 2591 17 to to IN cord-010119-t1x9gknd 2591 18 testing test VBG cord-010119-t1x9gknd 2591 19 with with IN cord-010119-t1x9gknd 2591 20 currently currently RB cord-010119-t1x9gknd 2591 21 available available JJ cord-010119-t1x9gknd 2591 22 IgG igg NN cord-010119-t1x9gknd 2591 23 subtype subtype NN cord-010119-t1x9gknd 2591 24 specific specific JJ cord-010119-t1x9gknd 2591 25 AHG AHG NNP cord-010119-t1x9gknd 2591 26 ( ( -LRB- cord-010119-t1x9gknd 2591 27 monoclonal monoclonal JJ cord-010119-t1x9gknd 2591 28 AHGs ahg NNS cord-010119-t1x9gknd 2591 29 from from IN cord-010119-t1x9gknd 2591 30 Southern Southern NNP cord-010119-t1x9gknd 2591 31 Biotech Biotech NNP cord-010119-t1x9gknd 2591 32 and and CC cord-010119-t1x9gknd 2591 33 Sanquin Sanquin NNP cord-010119-t1x9gknd 2591 34 , , , cord-010119-t1x9gknd 2591 35 polyclonal polyclonal JJ cord-010119-t1x9gknd 2591 36 AHGs ahg NNS cord-010119-t1x9gknd 2591 37 from from IN cord-010119-t1x9gknd 2591 38 Sanquin Sanquin NNP cord-010119-t1x9gknd 2591 39 and and CC cord-010119-t1x9gknd 2591 40 The the DT cord-010119-t1x9gknd 2591 41 BindingSite BindingSite NNP cord-010119-t1x9gknd 2591 42 ) ) -RRB- cord-010119-t1x9gknd 2591 43 . . . cord-010119-t1x9gknd 2592 1 All all DT cord-010119-t1x9gknd 2592 2 testing testing NN cord-010119-t1x9gknd 2592 3 was be VBD cord-010119-t1x9gknd 2592 4 carried carry VBN cord-010119-t1x9gknd 2592 5 out out RP cord-010119-t1x9gknd 2592 6 by by IN cord-010119-t1x9gknd 2592 7 flow flow NN cord-010119-t1x9gknd 2592 8 cytometry cytometry NN cord-010119-t1x9gknd 2592 9 . . . cord-010119-t1x9gknd 2593 1 Results result NNS cord-010119-t1x9gknd 2593 2 / / SYM cord-010119-t1x9gknd 2593 3 Findings finding NNS cord-010119-t1x9gknd 2593 4 : : : cord-010119-t1x9gknd 2593 5 Polyclonal Polyclonal NNP cord-010119-t1x9gknd 2593 6 reagents reagent NNS cord-010119-t1x9gknd 2593 7 against against IN cord-010119-t1x9gknd 2593 8 IgG2 igg2 NN cord-010119-t1x9gknd 2593 9 , , , cord-010119-t1x9gknd 2593 10 IgG3 IgG3 NNP cord-010119-t1x9gknd 2593 11 , , , cord-010119-t1x9gknd 2593 12 and and CC cord-010119-t1x9gknd 2593 13 IgG4 igg4 CD cord-010119-t1x9gknd 2594 1 had have VBD cord-010119-t1x9gknd 2594 2 cross cross NN cord-010119-t1x9gknd 2594 3 - - NN cord-010119-t1x9gknd 2594 4 reactivity reactivity NN cord-010119-t1x9gknd 2594 5 with with IN cord-010119-t1x9gknd 2594 6 variants variant NNS cord-010119-t1x9gknd 2594 7 found find VBN cord-010119-t1x9gknd 2594 8 in in IN cord-010119-t1x9gknd 2594 9 other other JJ cord-010119-t1x9gknd 2594 10 IgG IgG NNP cord-010119-t1x9gknd 2594 11 subclasses subclass NNS cord-010119-t1x9gknd 2594 12 , , , cord-010119-t1x9gknd 2594 13 and and CC cord-010119-t1x9gknd 2595 1 specific specific JJ cord-010119-t1x9gknd 2595 2 amino amino NN cord-010119-t1x9gknd 2595 3 acids acid NNS cord-010119-t1x9gknd 2595 4 responsible responsible JJ cord-010119-t1x9gknd 2595 5 were be VBD cord-010119-t1x9gknd 2595 6 identified identify VBN cord-010119-t1x9gknd 2595 7 by by IN cord-010119-t1x9gknd 2595 8 site site NN cord-010119-t1x9gknd 2595 9 directed direct VBN cord-010119-t1x9gknd 2595 10 mutagenesis mutagenesis NN cord-010119-t1x9gknd 2595 11 ( ( -LRB- cord-010119-t1x9gknd 2595 12 table table NN cord-010119-t1x9gknd 2595 13 1 1 CD cord-010119-t1x9gknd 2595 14 ) ) -RRB- cord-010119-t1x9gknd 2595 15 . . . cord-010119-t1x9gknd 2596 1 Titrations titration NNS cord-010119-t1x9gknd 2596 2 of of IN cord-010119-t1x9gknd 2596 3 the the DT cord-010119-t1x9gknd 2596 4 AHGs ahg NNS cord-010119-t1x9gknd 2596 5 did do VBD cord-010119-t1x9gknd 2596 6 not not RB cord-010119-t1x9gknd 2596 7 identify identify VB cord-010119-t1x9gknd 2596 8 a a DT cord-010119-t1x9gknd 2596 9 dilution dilution NN cord-010119-t1x9gknd 2596 10 at at IN cord-010119-t1x9gknd 2596 11 which which WDT cord-010119-t1x9gknd 2596 12 crossreactivities crossreactivities NNP cord-010119-t1x9gknd 2596 13 were be VBD cord-010119-t1x9gknd 2596 14 lost lose VBN cord-010119-t1x9gknd 2596 15 , , , cord-010119-t1x9gknd 2596 16 but but CC cord-010119-t1x9gknd 2596 17 authentic authentic JJ cord-010119-t1x9gknd 2596 18 targets target NNS cord-010119-t1x9gknd 2596 19 were be VBD cord-010119-t1x9gknd 2596 20 still still RB cord-010119-t1x9gknd 2596 21 detected detect VBN cord-010119-t1x9gknd 2596 22 . . . cord-010119-t1x9gknd 2597 1 However however RB cord-010119-t1x9gknd 2597 2 , , , cord-010119-t1x9gknd 2597 3 cross cross NN cord-010119-t1x9gknd 2597 4 - - NN cord-010119-t1x9gknd 2597 5 reactivity reactivity NN cord-010119-t1x9gknd 2597 6 could could MD cord-010119-t1x9gknd 2597 7 be be VB cord-010119-t1x9gknd 2597 8 neutralized neutralize VBN cord-010119-t1x9gknd 2597 9 by by IN cord-010119-t1x9gknd 2597 10 pre pre JJ cord-010119-t1x9gknd 2597 11 - - JJ cord-010119-t1x9gknd 2597 12 incubating incubating JJ cord-010119-t1x9gknd 2597 13 AHG AHG NNP cord-010119-t1x9gknd 2597 14 with with IN cord-010119-t1x9gknd 2597 15 the the DT cord-010119-t1x9gknd 2597 16 crossrecognized crossrecognized NNP cord-010119-t1x9gknd 2597 17 IgG IgG NNP cord-010119-t1x9gknd 2597 18 forms form NNS cord-010119-t1x9gknd 2597 19 ( ( -LRB- cord-010119-t1x9gknd 2597 20 against against IN cord-010119-t1x9gknd 2597 21 a a DT cord-010119-t1x9gknd 2597 22 third third JJ cord-010119-t1x9gknd 2597 23 party party NN cord-010119-t1x9gknd 2597 24 antigen antigen NN cord-010119-t1x9gknd 2597 25 ) ) -RRB- cord-010119-t1x9gknd 2597 26 ; ; : cord-010119-t1x9gknd 2597 27 the the DT cord-010119-t1x9gknd 2597 28 remaining remain VBG cord-010119-t1x9gknd 2597 29 reactivity reactivity NN cord-010119-t1x9gknd 2597 30 recognized recognize VBD cord-010119-t1x9gknd 2597 31 the the DT cord-010119-t1x9gknd 2597 32 intended intend VBN cord-010119-t1x9gknd 2597 33 IgG igg NN cord-010119-t1x9gknd 2597 34 subtype subtype NN cord-010119-t1x9gknd 2597 35 without without IN cord-010119-t1x9gknd 2597 36 detectable detectable JJ cord-010119-t1x9gknd 2597 37 cross cross JJ cord-010119-t1x9gknd 2597 38 - - NN cord-010119-t1x9gknd 2597 39 reactivity reactivity NN cord-010119-t1x9gknd 2597 40 . . . cord-010119-t1x9gknd 2598 1 No no DT cord-010119-t1x9gknd 2598 2 cross cross NN cord-010119-t1x9gknd 2598 3 - - NN cord-010119-t1x9gknd 2598 4 reactivity reactivity NN cord-010119-t1x9gknd 2598 5 was be VBD cord-010119-t1x9gknd 2598 6 detected detect VBN cord-010119-t1x9gknd 2598 7 for for IN cord-010119-t1x9gknd 2598 8 polyclonal polyclonal JJ cord-010119-t1x9gknd 2598 9 anti anti NNS cord-010119-t1x9gknd 2598 10 - - JJ cord-010119-t1x9gknd 2598 11 IgG1 igg1 JJ cord-010119-t1x9gknd 2598 12 or or CC cord-010119-t1x9gknd 2598 13 for for IN cord-010119-t1x9gknd 2598 14 any any DT cord-010119-t1x9gknd 2598 15 of of IN cord-010119-t1x9gknd 2598 16 the the DT cord-010119-t1x9gknd 2598 17 monoclonal monoclonal JJ cord-010119-t1x9gknd 2598 18 AHGs ahg NNS cord-010119-t1x9gknd 2598 19 tested test VBN cord-010119-t1x9gknd 2598 20 . . . cord-010119-t1x9gknd 2599 1 Monoclonal monoclonal JJ cord-010119-t1x9gknd 2599 2 anti anti JJ cord-010119-t1x9gknd 2599 3 - - NNP cord-010119-t1x9gknd 2599 4 IgG3 IgG3 NNP cord-010119-t1x9gknd 2599 5 had have VBD cord-010119-t1x9gknd 2599 6 a a DT cord-010119-t1x9gknd 2599 7 blindspot blindspot NN cord-010119-t1x9gknd 2599 8 for for IN cord-010119-t1x9gknd 2599 9 IgG3 IgG3 NNP cord-010119-t1x9gknd 2599 10 - - HYPH cord-010119-t1x9gknd 2599 11 04 04 CD cord-010119-t1x9gknd 2599 12 , , , cord-010119-t1x9gknd 2599 13 due due IN cord-010119-t1x9gknd 2599 14 to to IN cord-010119-t1x9gknd 2599 15 the the DT cord-010119-t1x9gknd 2599 16 shorter short JJR cord-010119-t1x9gknd 2599 17 hinge hinge NN cord-010119-t1x9gknd 2599 18 region region NN cord-010119-t1x9gknd 2599 19 on on IN cord-010119-t1x9gknd 2599 20 IgG3 IgG3 NNP cord-010119-t1x9gknd 2599 21 - - HYPH cord-010119-t1x9gknd 2599 22 04 04 CD cord-010119-t1x9gknd 2599 23 . . . cord-010119-t1x9gknd 2600 1 No no DT cord-010119-t1x9gknd 2600 2 blindspots blindspot NNS cord-010119-t1x9gknd 2600 3 were be VBD cord-010119-t1x9gknd 2600 4 detected detect VBN cord-010119-t1x9gknd 2600 5 in in IN cord-010119-t1x9gknd 2600 6 other other JJ cord-010119-t1x9gknd 2600 7 monoclonal monoclonal JJ cord-010119-t1x9gknd 2600 8 or or CC cord-010119-t1x9gknd 2600 9 polyclonal polyclonal JJ cord-010119-t1x9gknd 2600 10 AHG AHG NNP cord-010119-t1x9gknd 2600 11 . . . cord-010119-t1x9gknd 2601 1 Conclusion conclusion NN cord-010119-t1x9gknd 2601 2 : : : cord-010119-t1x9gknd 2602 1 The the DT cord-010119-t1x9gknd 2602 2 relative relative JJ cord-010119-t1x9gknd 2602 3 quantitation quantitation NN cord-010119-t1x9gknd 2602 4 of of IN cord-010119-t1x9gknd 2602 5 different different JJ cord-010119-t1x9gknd 2602 6 IgG igg NN cord-010119-t1x9gknd 2602 7 subtypes subtype NNS cord-010119-t1x9gknd 2602 8 has have VBZ cord-010119-t1x9gknd 2602 9 been be VBN cord-010119-t1x9gknd 2602 10 studied study VBN cord-010119-t1x9gknd 2602 11 in in IN cord-010119-t1x9gknd 2602 12 multiple multiple JJ cord-010119-t1x9gknd 2602 13 immune immune JJ cord-010119-t1x9gknd 2602 14 settings setting NNS cord-010119-t1x9gknd 2602 15 , , , cord-010119-t1x9gknd 2602 16 and and CC cord-010119-t1x9gknd 2602 17 plays play VBZ cord-010119-t1x9gknd 2602 18 important important JJ cord-010119-t1x9gknd 2602 19 roles role NNS cord-010119-t1x9gknd 2602 20 in in IN cord-010119-t1x9gknd 2602 21 diagnosis diagnosis NN cord-010119-t1x9gknd 2602 22 and and CC cord-010119-t1x9gknd 2602 23 research research NN cord-010119-t1x9gknd 2602 24 of of IN cord-010119-t1x9gknd 2602 25 human human JJ cord-010119-t1x9gknd 2602 26 disease disease NN cord-010119-t1x9gknd 2602 27 , , , cord-010119-t1x9gknd 2602 28 including include VBG cord-010119-t1x9gknd 2602 29 immunohematology immunohematology NN cord-010119-t1x9gknd 2602 30 . . . cord-010119-t1x9gknd 2603 1 Herein herein RB cord-010119-t1x9gknd 2603 2 , , , cord-010119-t1x9gknd 2603 3 we -PRON- PRP cord-010119-t1x9gknd 2603 4 demonstrate demonstrate VBP cord-010119-t1x9gknd 2603 5 that that IN cord-010119-t1x9gknd 2603 6 the the DT cord-010119-t1x9gknd 2603 7 reagents reagent NNS cord-010119-t1x9gknd 2603 8 used use VBN cord-010119-t1x9gknd 2603 9 to to TO cord-010119-t1x9gknd 2603 10 generate generate VB cord-010119-t1x9gknd 2603 11 this this DT cord-010119-t1x9gknd 2603 12 body body NN cord-010119-t1x9gknd 2603 13 of of IN cord-010119-t1x9gknd 2603 14 knowledge knowledge NN cord-010119-t1x9gknd 2603 15 suffer suffer VBP cord-010119-t1x9gknd 2603 16 problems problem NNS cord-010119-t1x9gknd 2603 17 of of IN cord-010119-t1x9gknd 2603 18 cross cross NN cord-010119-t1x9gknd 2603 19 - - NNS cord-010119-t1x9gknd 2603 20 reactivities reactivity NNS cord-010119-t1x9gknd 2603 21 and and CC cord-010119-t1x9gknd 2603 22 blindspots blindspot NNS cord-010119-t1x9gknd 2603 23 . . . cord-010119-t1x9gknd 2604 1 As as IN cord-010119-t1x9gknd 2604 2 such such JJ cord-010119-t1x9gknd 2604 3 , , , cord-010119-t1x9gknd 2604 4 the the DT cord-010119-t1x9gknd 2604 5 existing exist VBG cord-010119-t1x9gknd 2604 6 data datum NNS cord-010119-t1x9gknd 2604 7 regarding regard VBG cord-010119-t1x9gknd 2604 8 IgG IgG NNP cord-010119-t1x9gknd 2604 9 subtype subtype NN cord-010119-t1x9gknd 2604 10 biology biology NN cord-010119-t1x9gknd 2604 11 may may MD cord-010119-t1x9gknd 2604 12 have have VB cord-010119-t1x9gknd 2604 13 some some DT cord-010119-t1x9gknd 2604 14 inaccuracies inaccuracy NNS cord-010119-t1x9gknd 2604 15 as as IN cord-010119-t1x9gknd 2604 16 a a DT cord-010119-t1x9gknd 2604 17 result result NN cord-010119-t1x9gknd 2604 18 of of IN cord-010119-t1x9gknd 2604 19 these these DT cord-010119-t1x9gknd 2604 20 defects defect NNS cord-010119-t1x9gknd 2604 21 in in IN cord-010119-t1x9gknd 2604 22 IgG IgG NNP cord-010119-t1x9gknd 2604 23 specific specific JJ cord-010119-t1x9gknd 2604 24 AHG AHG NNP cord-010119-t1x9gknd 2604 25 . . . cord-010119-t1x9gknd 2605 1 Genotype genotype NN cord-010119-t1x9gknd 2605 2 Matching match VBG cord-010119-t1x9gknd 2605 3 for for IN cord-010119-t1x9gknd 2605 4 Pediatric Pediatric NNP cord-010119-t1x9gknd 2605 5 Sickle Sickle NNP cord-010119-t1x9gknd 2605 6 Cell Cell NNP cord-010119-t1x9gknd 2605 7 Disease Disease NNP cord-010119-t1x9gknd 2605 8 Patients Patients NNP cord-010119-t1x9gknd 2605 9 Nancy Nancy NNP cord-010119-t1x9gknd 2605 10 Robitaille Robitaille NNP cord-010119-t1x9gknd 2605 11 * * NFP cord-010119-t1x9gknd 2605 12 1 1 CD cord-010119-t1x9gknd 2605 13 , , , cord-010119-t1x9gknd 2605 14 Yves Yves NNP cord-010119-t1x9gknd 2605 15 Dominique Dominique NNP cord-010119-t1x9gknd 2605 16 Pastore Pastore NNP cord-010119-t1x9gknd 2605 17 1 1 CD cord-010119-t1x9gknd 2605 18 and and CC cord-010119-t1x9gknd 2605 19 Maryse Maryse NNP cord-010119-t1x9gknd 2605 20 St St NNP cord-010119-t1x9gknd 2605 21 - - HYPH cord-010119-t1x9gknd 2605 22 Louis Louis NNP cord-010119-t1x9gknd 2605 23 2 2 CD cord-010119-t1x9gknd 2605 24 . . . cord-010119-t1x9gknd 2606 1 1 1 LS cord-010119-t1x9gknd 2607 1 CHU CHU NNP cord-010119-t1x9gknd 2607 2 Sainte Sainte NNP cord-010119-t1x9gknd 2607 3 - - HYPH cord-010119-t1x9gknd 2607 4 Justine Justine NNP cord-010119-t1x9gknd 2607 5 , , , cord-010119-t1x9gknd 2607 6 2 2 CD cord-010119-t1x9gknd 2607 7 Hema Hema NNP cord-010119-t1x9gknd 2607 8 - - HYPH cord-010119-t1x9gknd 2607 9 Quebec Quebec NNP cord-010119-t1x9gknd 2607 10 Background Background NNP cord-010119-t1x9gknd 2607 11 / / SYM cord-010119-t1x9gknd 2607 12 Case Case NNP cord-010119-t1x9gknd 2607 13 Studies Studies NNPS cord-010119-t1x9gknd 2607 14 : : : cord-010119-t1x9gknd 2608 1 Among among IN cord-010119-t1x9gknd 2608 2 the the DT cord-010119-t1x9gknd 2608 3 different different JJ cord-010119-t1x9gknd 2608 4 treatment treatment NN cord-010119-t1x9gknd 2608 5 modalities modality NNS cord-010119-t1x9gknd 2608 6 available available JJ cord-010119-t1x9gknd 2608 7 for for IN cord-010119-t1x9gknd 2608 8 sickle sickle NN cord-010119-t1x9gknd 2608 9 cell cell NN cord-010119-t1x9gknd 2608 10 disease disease NN cord-010119-t1x9gknd 2608 11 ( ( -LRB- cord-010119-t1x9gknd 2608 12 SCD SCD NNP cord-010119-t1x9gknd 2608 13 ) ) -RRB- cord-010119-t1x9gknd 2608 14 , , , cord-010119-t1x9gknd 2608 15 blood blood NN cord-010119-t1x9gknd 2608 16 transfusion transfusion NN cord-010119-t1x9gknd 2608 17 is be VBZ cord-010119-t1x9gknd 2608 18 frequently frequently RB cord-010119-t1x9gknd 2608 19 used use VBN cord-010119-t1x9gknd 2608 20 . . . cord-010119-t1x9gknd 2609 1 However however RB cord-010119-t1x9gknd 2609 2 , , , cord-010119-t1x9gknd 2609 3 alloimmunisation alloimmunisation NN cord-010119-t1x9gknd 2609 4 remains remain VBZ cord-010119-t1x9gknd 2609 5 a a DT cord-010119-t1x9gknd 2609 6 significant significant JJ cord-010119-t1x9gknd 2609 7 problem problem NN cord-010119-t1x9gknd 2609 8 , , , cord-010119-t1x9gknd 2609 9 even even RB cord-010119-t1x9gknd 2609 10 if if IN cord-010119-t1x9gknd 2609 11 prophylactic prophylactic JJ cord-010119-t1x9gknd 2609 12 antigen antigen NN cord-010119-t1x9gknd 2609 13 matching matching NN cord-010119-t1x9gknd 2609 14 is be VBZ cord-010119-t1x9gknd 2609 15 performed perform VBN cord-010119-t1x9gknd 2609 16 for for IN cord-010119-t1x9gknd 2609 17 C C NNP cord-010119-t1x9gknd 2609 18 , , , cord-010119-t1x9gknd 2609 19 E E NNP cord-010119-t1x9gknd 2609 20 and and CC cord-010119-t1x9gknd 2609 21 Kell Kell NNP cord-010119-t1x9gknd 2609 22 antigens antigen NNS cord-010119-t1x9gknd 2609 23 . . . cord-010119-t1x9gknd 2610 1 This this DT cord-010119-t1x9gknd 2610 2 is be VBZ cord-010119-t1x9gknd 2610 3 partly partly RB cord-010119-t1x9gknd 2610 4 explained explain VBN cord-010119-t1x9gknd 2610 5 by by IN cord-010119-t1x9gknd 2610 6 different different JJ cord-010119-t1x9gknd 2610 7 antigen antigen NN cord-010119-t1x9gknd 2610 8 frequency frequency NN cord-010119-t1x9gknd 2610 9 among among IN cord-010119-t1x9gknd 2610 10 Caucasian caucasian JJ cord-010119-t1x9gknd 2610 11 blood blood NN cord-010119-t1x9gknd 2610 12 donors donor NNS cord-010119-t1x9gknd 2610 13 and and CC cord-010119-t1x9gknd 2610 14 African african JJ cord-010119-t1x9gknd 2610 15 - - HYPH cord-010119-t1x9gknd 2610 16 American american JJ cord-010119-t1x9gknd 2610 17 recipients recipient NNS cord-010119-t1x9gknd 2610 18 , , , cord-010119-t1x9gknd 2610 19 and and CC cord-010119-t1x9gknd 2610 20 by by IN cord-010119-t1x9gknd 2610 21 variants variant NNS cord-010119-t1x9gknd 2610 22 in in IN cord-010119-t1x9gknd 2610 23 the the DT cord-010119-t1x9gknd 2610 24 Rh Rh NNP cord-010119-t1x9gknd 2610 25 blood blood NN cord-010119-t1x9gknd 2610 26 group group NN cord-010119-t1x9gknd 2610 27 of of IN cord-010119-t1x9gknd 2610 28 people people NNS cord-010119-t1x9gknd 2610 29 of of IN cord-010119-t1x9gknd 2610 30 African african JJ cord-010119-t1x9gknd 2610 31 - - HYPH cord-010119-t1x9gknd 2610 32 descent descent NN cord-010119-t1x9gknd 2610 33 . . . cord-010119-t1x9gknd 2611 1 Blood blood NN cord-010119-t1x9gknd 2611 2 group group NN cord-010119-t1x9gknd 2611 3 genotyping genotyping NN cord-010119-t1x9gknd 2611 4 has have VBZ cord-010119-t1x9gknd 2611 5 been be VBN cord-010119-t1x9gknd 2611 6 proposed propose VBN cord-010119-t1x9gknd 2611 7 as as IN cord-010119-t1x9gknd 2611 8 a a DT cord-010119-t1x9gknd 2611 9 potential potential JJ cord-010119-t1x9gknd 2611 10 way way NN cord-010119-t1x9gknd 2611 11 to to TO cord-010119-t1x9gknd 2611 12 alleviate alleviate VB cord-010119-t1x9gknd 2611 13 this this DT cord-010119-t1x9gknd 2611 14 problem problem NN cord-010119-t1x9gknd 2611 15 . . . cord-010119-t1x9gknd 2612 1 The the DT cord-010119-t1x9gknd 2612 2 SCD SCD NNP cord-010119-t1x9gknd 2612 3 cohort cohort NN cord-010119-t1x9gknd 2612 4 of of IN cord-010119-t1x9gknd 2612 5 a a DT cord-010119-t1x9gknd 2612 6 pediatric pediatric JJ cord-010119-t1x9gknd 2612 7 academic academic JJ cord-010119-t1x9gknd 2612 8 hospital hospital NN cord-010119-t1x9gknd 2612 9 was be VBD cord-010119-t1x9gknd 2612 10 genotyped genotype VBN cord-010119-t1x9gknd 2612 11 for for IN cord-010119-t1x9gknd 2612 12 RHD RHD NNP cord-010119-t1x9gknd 2612 13 , , , cord-010119-t1x9gknd 2612 14 RHCE RHCE NNP cord-010119-t1x9gknd 2612 15 and and CC cord-010119-t1x9gknd 2612 16 FY FY NNP cord-010119-t1x9gknd 2612 17 genes gene NNS cord-010119-t1x9gknd 2612 18 . . . cord-010119-t1x9gknd 2613 1 The the DT cord-010119-t1x9gknd 2613 2 primary primary JJ cord-010119-t1x9gknd 2613 3 objective objective NN cord-010119-t1x9gknd 2613 4 of of IN cord-010119-t1x9gknd 2613 5 our -PRON- PRP$ cord-010119-t1x9gknd 2613 6 study study NN cord-010119-t1x9gknd 2613 7 was be VBD cord-010119-t1x9gknd 2613 8 to to TO cord-010119-t1x9gknd 2613 9 evaluate evaluate VB cord-010119-t1x9gknd 2613 10 whether whether IN cord-010119-t1x9gknd 2613 11 compatible compatible JJ cord-010119-t1x9gknd 2613 12 genotyped genotype VBN cord-010119-t1x9gknd 2613 13 blood blood NN cord-010119-t1x9gknd 2613 14 donors donor NNS cord-010119-t1x9gknd 2613 15 presenting present VBG cord-010119-t1x9gknd 2613 16 similar similar JJ cord-010119-t1x9gknd 2613 17 Rh Rh NNP cord-010119-t1x9gknd 2613 18 variants variant NNS cord-010119-t1x9gknd 2613 19 could could MD cord-010119-t1x9gknd 2613 20 be be VB cord-010119-t1x9gknd 2613 21 identified identify VBN cord-010119-t1x9gknd 2613 22 . . . cord-010119-t1x9gknd 2614 1 Study Study NNP cord-010119-t1x9gknd 2614 2 Design Design NNP cord-010119-t1x9gknd 2614 3 / / SYM cord-010119-t1x9gknd 2614 4 Methods method NNS cord-010119-t1x9gknd 2614 5 : : : cord-010119-t1x9gknd 2615 1 Since since IN cord-010119-t1x9gknd 2615 2 2008 2008 CD cord-010119-t1x9gknd 2615 3 , , , cord-010119-t1x9gknd 2615 4 our -PRON- PRP$ cord-010119-t1x9gknd 2615 5 local local JJ cord-010119-t1x9gknd 2615 6 blood blood NN cord-010119-t1x9gknd 2615 7 provider provider NN cord-010119-t1x9gknd 2615 8 intensified intensify VBD cord-010119-t1x9gknd 2615 9 recruitment recruitment NN cord-010119-t1x9gknd 2615 10 of of IN cord-010119-t1x9gknd 2615 11 African african JJ cord-010119-t1x9gknd 2615 12 - - HYPH cord-010119-t1x9gknd 2615 13 descent descent NN cord-010119-t1x9gknd 2615 14 blood blood NN cord-010119-t1x9gknd 2615 15 donors donor NNS cord-010119-t1x9gknd 2615 16 . . . cord-010119-t1x9gknd 2616 1 These these DT cord-010119-t1x9gknd 2616 2 donors donor NNS cord-010119-t1x9gknd 2616 3 were be VBD cord-010119-t1x9gknd 2616 4 phenotyped phenotype VBN cord-010119-t1x9gknd 2616 5 and and CC cord-010119-t1x9gknd 2616 6 genotyped genotype VBN cord-010119-t1x9gknd 2616 7 for for IN cord-010119-t1x9gknd 2616 8 clinically clinically RB cord-010119-t1x9gknd 2616 9 relevant relevant JJ cord-010119-t1x9gknd 2616 10 antigens antigen NNS cord-010119-t1x9gknd 2616 11 by by IN cord-010119-t1x9gknd 2616 12 different different JJ cord-010119-t1x9gknd 2616 13 means mean NNS cord-010119-t1x9gknd 2616 14 : : : cord-010119-t1x9gknd 2617 1 GenomeLab GenomeLab NNP cord-010119-t1x9gknd 2617 2 SNP SNP NNP cord-010119-t1x9gknd 2617 3 Stream Stream NNP cord-010119-t1x9gknd 2617 4 , , , cord-010119-t1x9gknd 2617 5 laboratory laboratory NN cord-010119-t1x9gknd 2617 6 - - HYPH cord-010119-t1x9gknd 2617 7 developped developpe VBN cord-010119-t1x9gknd 2617 8 assays assay NNS cord-010119-t1x9gknd 2617 9 and and CC cord-010119-t1x9gknd 2617 10 IDCoreXT IDCoreXT NNP cord-010119-t1x9gknd 2617 11 . . . cord-010119-t1x9gknd 2618 1 As as IN cord-010119-t1x9gknd 2618 2 of of IN cord-010119-t1x9gknd 2618 3 2014 2014 CD cord-010119-t1x9gknd 2618 4 , , , cord-010119-t1x9gknd 2618 5 205 205 CD cord-010119-t1x9gknd 2618 6 SCD SCD NNP cord-010119-t1x9gknd 2618 7 children child NNS cord-010119-t1x9gknd 2618 8 were be VBD cord-010119-t1x9gknd 2618 9 genotyped genotype VBN cord-010119-t1x9gknd 2618 10 by by IN cord-010119-t1x9gknd 2618 11 sequencing sequence VBG cord-010119-t1x9gknd 2618 12 RHD RHD NNP cord-010119-t1x9gknd 2618 13 , , , cord-010119-t1x9gknd 2618 14 RHCE RHCE NNP cord-010119-t1x9gknd 2618 15 and and CC cord-010119-t1x9gknd 2618 16 FY FY NNP cord-010119-t1x9gknd 2618 17 cDNAs cDNAs NNPS cord-010119-t1x9gknd 2618 18 after after IN cord-010119-t1x9gknd 2618 19 obtaining obtain VBG cord-010119-t1x9gknd 2618 20 informed informed JJ cord-010119-t1x9gknd 2618 21 consent consent NN cord-010119-t1x9gknd 2618 22 . . . cord-010119-t1x9gknd 2619 1 Extended extended JJ cord-010119-t1x9gknd 2619 2 red red JJ cord-010119-t1x9gknd 2619 3 blood blood NN cord-010119-t1x9gknd 2619 4 cell cell NN cord-010119-t1x9gknd 2619 5 phenotypes phenotype NNS cord-010119-t1x9gknd 2619 6 were be VBD cord-010119-t1x9gknd 2619 7 done do VBN cord-010119-t1x9gknd 2619 8 at at IN cord-010119-t1x9gknd 2619 9 diagnosis diagnosis NN cord-010119-t1x9gknd 2619 10 at at IN cord-010119-t1x9gknd 2619 11 the the DT cord-010119-t1x9gknd 2619 12 hospital hospital NN cord-010119-t1x9gknd 2619 13 . . . cord-010119-t1x9gknd 2620 1 Patients patient NNS cord-010119-t1x9gknd 2620 2 ' ' POS cord-010119-t1x9gknd 2620 3 genotypes genotype NNS cord-010119-t1x9gknd 2620 4 were be VBD cord-010119-t1x9gknd 2620 5 compared compare VBN cord-010119-t1x9gknd 2620 6 to to IN cord-010119-t1x9gknd 2620 7 H h NN cord-010119-t1x9gknd 2621 1 ema ema NNP cord-010119-t1x9gknd 2621 2 - - HYPH cord-010119-t1x9gknd 2621 3 Qu Qu NNP cord-010119-t1x9gknd 2621 4 ebec ebec NNP cord-010119-t1x9gknd 2621 5 's 's POS cord-010119-t1x9gknd 2621 6 donor donor NN cord-010119-t1x9gknd 2621 7 database database NN cord-010119-t1x9gknd 2621 8 to to TO cord-010119-t1x9gknd 2621 9 attribute attribute VB cord-010119-t1x9gknd 2621 10 blood blood NN cord-010119-t1x9gknd 2621 11 donors donor NNS cord-010119-t1x9gknd 2621 12 to to IN cord-010119-t1x9gknd 2621 13 specific specific JJ cord-010119-t1x9gknd 2621 14 patients patient NNS cord-010119-t1x9gknd 2621 15 . . . cord-010119-t1x9gknd 2622 1 Results result NNS cord-010119-t1x9gknd 2622 2 / / SYM cord-010119-t1x9gknd 2622 3 Findings finding NNS cord-010119-t1x9gknd 2622 4 : : : cord-010119-t1x9gknd 2623 1 From from IN cord-010119-t1x9gknd 2623 2 diagnosis diagnosis NN cord-010119-t1x9gknd 2623 3 until until IN cord-010119-t1x9gknd 2623 4 September September NNP cord-010119-t1x9gknd 2623 5 2016 2016 CD cord-010119-t1x9gknd 2623 6 , , , cord-010119-t1x9gknd 2623 7 117 117 CD cord-010119-t1x9gknd 2623 8 ( ( -LRB- cord-010119-t1x9gknd 2623 9 57 57 CD cord-010119-t1x9gknd 2623 10 % % NN cord-010119-t1x9gknd 2623 11 ) ) -RRB- cord-010119-t1x9gknd 2623 12 patients patient NNS cord-010119-t1x9gknd 2623 13 had have VBD cord-010119-t1x9gknd 2623 14 been be VBN cord-010119-t1x9gknd 2623 15 transfused transfuse VBN cord-010119-t1x9gknd 2623 16 and and CC cord-010119-t1x9gknd 2623 17 14 14 CD cord-010119-t1x9gknd 2623 18 had have VBD cord-010119-t1x9gknd 2623 19 antibodies antibody NNS cord-010119-t1x9gknd 2623 20 with with IN cord-010119-t1x9gknd 2623 21 known know VBN cord-010119-t1x9gknd 2623 22 blood blood NN cord-010119-t1x9gknd 2623 23 group group NN cord-010119-t1x9gknd 2623 24 antigen antigen NN cord-010119-t1x9gknd 2623 25 specificity specificity NN cord-010119-t1x9gknd 2623 26 : : : cord-010119-t1x9gknd 2623 27 anti anti JJ cord-010119-t1x9gknd 2623 28 - - NNP cord-010119-t1x9gknd 2623 29 C c JJ cord-010119-t1x9gknd 2623 30 , , , cord-010119-t1x9gknd 2623 31 anti anti JJ cord-010119-t1x9gknd 2623 32 - - JJ cord-010119-t1x9gknd 2623 33 E e JJ cord-010119-t1x9gknd 2623 34 ( ( -LRB- cord-010119-t1x9gknd 2623 35 2 2 CD cord-010119-t1x9gknd 2623 36 ) ) -RRB- cord-010119-t1x9gknd 2623 37 , , , cord-010119-t1x9gknd 2623 38 anti anti NNP cord-010119-t1x9gknd 2623 39 - - NNP cord-010119-t1x9gknd 2623 40 hrb hrb NNP cord-010119-t1x9gknd 2623 41 , , , cord-010119-t1x9gknd 2623 42 anti anti NNP cord-010119-t1x9gknd 2623 43 - - NNP cord-010119-t1x9gknd 2623 44 Fya Fya NNP cord-010119-t1x9gknd 2623 45 , , , cord-010119-t1x9gknd 2623 46 anti anti JJ cord-010119-t1x9gknd 2623 47 - - NNP cord-010119-t1x9gknd 2623 48 Jka jka JJ cord-010119-t1x9gknd 2623 49 , , , cord-010119-t1x9gknd 2623 50 anti anti JJ cord-010119-t1x9gknd 2623 51 - - NN cord-010119-t1x9gknd 2623 52 Jkb Jkb NNP cord-010119-t1x9gknd 2623 53 ( ( -LRB- cord-010119-t1x9gknd 2623 54 2 2 CD cord-010119-t1x9gknd 2623 55 ) ) -RRB- cord-010119-t1x9gknd 2623 56 , , , cord-010119-t1x9gknd 2623 57 anti anti NNP cord-010119-t1x9gknd 2623 58 - - NNP cord-010119-t1x9gknd 2623 59 S s JJ cord-010119-t1x9gknd 2623 60 , , , cord-010119-t1x9gknd 2623 61 anti anti NNP cord-010119-t1x9gknd 2623 62 - - NNP cord-010119-t1x9gknd 2623 63 M m JJ cord-010119-t1x9gknd 2623 64 , , , cord-010119-t1x9gknd 2623 65 anti anti JJ cord-010119-t1x9gknd 2623 66 - - JJ cord-010119-t1x9gknd 2623 67 Sc2 sc2 JJ cord-010119-t1x9gknd 2623 68 , , , cord-010119-t1x9gknd 2623 69 anti anti JJ cord-010119-t1x9gknd 2623 70 - - JJ cord-010119-t1x9gknd 2623 71 Leb leb JJ cord-010119-t1x9gknd 2623 72 ( ( -LRB- cord-010119-t1x9gknd 2623 73 2 2 CD cord-010119-t1x9gknd 2623 74 ) ) -RRB- cord-010119-t1x9gknd 2623 75 . . . cord-010119-t1x9gknd 2624 1 Seventeen seventeen CD cord-010119-t1x9gknd 2624 2 patients patient NNS cord-010119-t1x9gknd 2624 3 ( ( -LRB- cord-010119-t1x9gknd 2624 4 8.3 8.3 CD cord-010119-t1x9gknd 2624 5 % % NN cord-010119-t1x9gknd 2624 6 ) ) -RRB- cord-010119-t1x9gknd 2624 7 were be VBD cord-010119-t1x9gknd 2624 8 either either CC cord-010119-t1x9gknd 2624 9 D2 d2 NN cord-010119-t1x9gknd 2624 10 or or CC cord-010119-t1x9gknd 2624 11 partial partial JJ cord-010119-t1x9gknd 2624 12 D. D. NNP cord-010119-t1x9gknd 2624 13 RHCE RHCE NNP cord-010119-t1x9gknd 2624 14 results result NNS cord-010119-t1x9gknd 2624 15 showed show VBD cord-010119-t1x9gknd 2624 16 that that IN cord-010119-t1x9gknd 2624 17 163 163 CD cord-010119-t1x9gknd 2624 18 patients patient NNS cord-010119-t1x9gknd 2624 19 expressed express VBD cord-010119-t1x9gknd 2624 20 a a DT cord-010119-t1x9gknd 2624 21 normal normal JJ cord-010119-t1x9gknd 2624 22 c c NN cord-010119-t1x9gknd 2624 23 antigen antigen NN cord-010119-t1x9gknd 2624 24 and and CC cord-010119-t1x9gknd 2624 25 32 32 CD cord-010119-t1x9gknd 2624 26 expressed express VBD cord-010119-t1x9gknd 2624 27 partial partial JJ cord-010119-t1x9gknd 2624 28 c. c. NN cord-010119-t1x9gknd 2624 29 As as IN cord-010119-t1x9gknd 2624 30 for for IN cord-010119-t1x9gknd 2624 31 e e NNP cord-010119-t1x9gknd 2624 32 antigen antigen NNP cord-010119-t1x9gknd 2624 33 , , , cord-010119-t1x9gknd 2624 34 163 163 CD cord-010119-t1x9gknd 2624 35 had have VBD cord-010119-t1x9gknd 2624 36 a a DT cord-010119-t1x9gknd 2624 37 normal normal JJ cord-010119-t1x9gknd 2624 38 antigen antigen NN cord-010119-t1x9gknd 2624 39 , , , cord-010119-t1x9gknd 2625 1 38 38 CD cord-010119-t1x9gknd 2625 2 bore bore NN cord-010119-t1x9gknd 2625 3 a a DT cord-010119-t1x9gknd 2625 4 partial partial JJ cord-010119-t1x9gknd 2625 5 antigen antigen NN cord-010119-t1x9gknd 2625 6 and and CC cord-010119-t1x9gknd 2625 7 3 3 CD cord-010119-t1x9gknd 2625 8 were be VBD cord-010119-t1x9gknd 2625 9 weakly weakly RB cord-010119-t1x9gknd 2625 10 expressed express VBN cord-010119-t1x9gknd 2625 11 . . . cord-010119-t1x9gknd 2626 1 Fy(a2b2 Fy(a2b2 NNP cord-010119-t1x9gknd 2626 2 ) ) -RRB- cord-010119-t1x9gknd 2626 3 phenotype phenotype NN cord-010119-t1x9gknd 2626 4 was be VBD cord-010119-t1x9gknd 2626 5 found find VBN cord-010119-t1x9gknd 2626 6 in in IN cord-010119-t1x9gknd 2626 7 182 182 CD cord-010119-t1x9gknd 2626 8 ( ( -LRB- cord-010119-t1x9gknd 2626 9 89 89 CD cord-010119-t1x9gknd 2626 10 % % NN cord-010119-t1x9gknd 2626 11 ) ) -RRB- cord-010119-t1x9gknd 2626 12 patients patient NNS cord-010119-t1x9gknd 2626 13 . . . cord-010119-t1x9gknd 2627 1 A a DT cord-010119-t1x9gknd 2627 2 total total NN cord-010119-t1x9gknd 2627 3 of of IN cord-010119-t1x9gknd 2627 4 2606 2606 CD cord-010119-t1x9gknd 2627 5 genotyped genotype VBD cord-010119-t1x9gknd 2627 6 blood blood NN cord-010119-t1x9gknd 2627 7 donors donor NNS cord-010119-t1x9gknd 2627 8 of of IN cord-010119-t1x9gknd 2627 9 African african JJ cord-010119-t1x9gknd 2627 10 - - HYPH cord-010119-t1x9gknd 2627 11 descent descent NN cord-010119-t1x9gknd 2627 12 were be VBD cord-010119-t1x9gknd 2627 13 available available JJ cord-010119-t1x9gknd 2627 14 . . . cord-010119-t1x9gknd 2628 1 The the DT cord-010119-t1x9gknd 2628 2 table table NN cord-010119-t1x9gknd 2628 3 below below RB cord-010119-t1x9gknd 2628 4 indicates indicate VBZ cord-010119-t1x9gknd 2628 5 the the DT cord-010119-t1x9gknd 2628 6 compatibility compatibility NN cord-010119-t1x9gknd 2628 7 with with IN cord-010119-t1x9gknd 2628 8 these these DT cord-010119-t1x9gknd 2628 9 donors donor NNS cord-010119-t1x9gknd 2628 10 . . . cord-010119-t1x9gknd 2629 1 Conclusion conclusion NN cord-010119-t1x9gknd 2629 2 : : : cord-010119-t1x9gknd 2630 1 This this DT cord-010119-t1x9gknd 2630 2 study study NN cord-010119-t1x9gknd 2630 3 shows show VBZ cord-010119-t1x9gknd 2630 4 that that IN cord-010119-t1x9gknd 2630 5 several several JJ cord-010119-t1x9gknd 2630 6 patients patient NNS cord-010119-t1x9gknd 2630 7 have have VBP cord-010119-t1x9gknd 2630 8 RHCE RHCE NNP cord-010119-t1x9gknd 2630 9 variants variant NNS cord-010119-t1x9gknd 2630 10 difficult difficult JJ cord-010119-t1x9gknd 2630 11 to to TO cord-010119-t1x9gknd 2630 12 match match VB cord-010119-t1x9gknd 2630 13 , , , cord-010119-t1x9gknd 2630 14 even even RB cord-010119-t1x9gknd 2630 15 with with IN cord-010119-t1x9gknd 2630 16 available available JJ cord-010119-t1x9gknd 2630 17 genotyped genotype VBN cord-010119-t1x9gknd 2630 18 blood blood NN cord-010119-t1x9gknd 2630 19 donors donor NNS cord-010119-t1x9gknd 2630 20 from from IN cord-010119-t1x9gknd 2630 21 their -PRON- PRP$ cord-010119-t1x9gknd 2630 22 community community NN cord-010119-t1x9gknd 2630 23 . . . cord-010119-t1x9gknd 2631 1 Although although IN cord-010119-t1x9gknd 2631 2 this this DT cord-010119-t1x9gknd 2631 3 measure measure NN cord-010119-t1x9gknd 2631 4 is be VBZ cord-010119-t1x9gknd 2631 5 probably probably RB cord-010119-t1x9gknd 2631 6 beneficial beneficial JJ cord-010119-t1x9gknd 2631 7 to to TO cord-010119-t1x9gknd 2631 8 decrease decrease VB cord-010119-t1x9gknd 2631 9 alloimmunisation alloimmunisation NN cord-010119-t1x9gknd 2631 10 , , , cord-010119-t1x9gknd 2631 11 a a DT cord-010119-t1x9gknd 2631 12 larger large JJR cord-010119-t1x9gknd 2631 13 donor donor NN cord-010119-t1x9gknd 2631 14 pool pool NN cord-010119-t1x9gknd 2631 15 is be VBZ cord-010119-t1x9gknd 2631 16 still still RB cord-010119-t1x9gknd 2631 17 needed need VBN cord-010119-t1x9gknd 2631 18 to to TO cord-010119-t1x9gknd 2631 19 fulfill fulfill VB cord-010119-t1x9gknd 2631 20 the the DT cord-010119-t1x9gknd 2631 21 patients patient NNS cord-010119-t1x9gknd 2631 22 ' ' POS cord-010119-t1x9gknd 2631 23 needs need NNS cord-010119-t1x9gknd 2631 24 . . . cord-010119-t1x9gknd 2632 1 The the DT cord-010119-t1x9gknd 2632 2 continued continued JJ cord-010119-t1x9gknd 2632 3 effort effort NN cord-010119-t1x9gknd 2632 4 put put VBN cord-010119-t1x9gknd 2632 5 towards towards IN cord-010119-t1x9gknd 2632 6 recruitment recruitment NN cord-010119-t1x9gknd 2632 7 and and CC cord-010119-t1x9gknd 2632 8 pheno pheno NN cord-010119-t1x9gknd 2632 9 / / SYM cord-010119-t1x9gknd 2632 10 genotyping genotyping NN cord-010119-t1x9gknd 2632 11 should should MD cord-010119-t1x9gknd 2632 12 improve improve VB cord-010119-t1x9gknd 2632 13 the the DT cord-010119-t1x9gknd 2632 14 situation situation NN cord-010119-t1x9gknd 2632 15 . . . cord-010119-t1x9gknd 2633 1 Using use VBG cord-010119-t1x9gknd 2633 2 Genetic genetic JJ cord-010119-t1x9gknd 2633 3 Markers Markers NNPS cord-010119-t1x9gknd 2633 4 to to IN cord-010119-t1x9gknd 2633 5 Select Select NNP cord-010119-t1x9gknd 2633 6 Responders Responders NNPS cord-010119-t1x9gknd 2633 7 and and CC cord-010119-t1x9gknd 2633 8 Non Non NNP cord-010119-t1x9gknd 2633 9 - - NNP cord-010119-t1x9gknd 2633 10 Responders Responders NNPS cord-010119-t1x9gknd 2633 11 Sickle Sickle NNP cord-010119-t1x9gknd 2633 12 Cell Cell NNP cord-010119-t1x9gknd 2633 13 Disease Disease NNP cord-010119-t1x9gknd 2633 14 ( ( -LRB- cord-010119-t1x9gknd 2633 15 SCD SCD NNP cord-010119-t1x9gknd 2633 16 ) ) -RRB- cord-010119-t1x9gknd 2633 17 Patients Patients NNP cord-010119-t1x9gknd 2633 18 for for IN cord-010119-t1x9gknd 2633 19 Transfusion Transfusion NNP cord-010119-t1x9gknd 2633 20 with with IN cord-010119-t1x9gknd 2633 21 RH RH NNP cord-010119-t1x9gknd 2633 22 Haplotype Haplotype NNP cord-010119-t1x9gknd 2633 23 Matching Matching NNP cord-010119-t1x9gknd 2633 24 Red Red NNP cord-010119-t1x9gknd 2633 25 Blood Blood NNP cord-010119-t1x9gknd 2633 26 Cell Cell NNP cord-010119-t1x9gknd 2633 27 ( ( -LRB- cord-010119-t1x9gknd 2633 28 RBC RBC NNP cord-010119-t1x9gknd 2633 29 ) ) -RRB- cord-010119-t1x9gknd 2633 30 Units unit NNS cord-010119-t1x9gknd 2634 1 Tamires Tamires NNP cord-010119-t1x9gknd 2634 2 Delfino Delfino NNP cord-010119-t1x9gknd 2634 3 dos do NNS cord-010119-t1x9gknd 2634 4 Santos Santos NNP cord-010119-t1x9gknd 2634 5 1 1 CD cord-010119-t1x9gknd 2634 6 , , , cord-010119-t1x9gknd 2634 7 Emilia Emilia NNP cord-010119-t1x9gknd 2634 8 Sippert Sippert NNP cord-010119-t1x9gknd 2634 9 1 1 CD cord-010119-t1x9gknd 2634 10 , , , cord-010119-t1x9gknd 2634 11 Mayra Mayra NNP cord-010119-t1x9gknd 2634 12 Dorigan Dorigan NNP cord-010119-t1x9gknd 2634 13 de de NNP cord-010119-t1x9gknd 2634 14 Macedo Macedo NNP cord-010119-t1x9gknd 2634 15 1 1 CD cord-010119-t1x9gknd 2634 16 , , , cord-010119-t1x9gknd 2634 17 Sheila Sheila NNP cord-010119-t1x9gknd 2634 18 Fatima Fatima NNP cord-010119-t1x9gknd 2634 19 Perecin Perecin NNP cord-010119-t1x9gknd 2635 1 Menegati Menegati NNP cord-010119-t1x9gknd 2635 2 1 1 CD cord-010119-t1x9gknd 2635 3 and and CC cord-010119-t1x9gknd 2635 4 Lilian Lilian NNP cord-010119-t1x9gknd 2635 5 Castilho Castilho NNP cord-010119-t1x9gknd 2635 6 * * NFP cord-010119-t1x9gknd 2635 7 1,2 1,2 CD cord-010119-t1x9gknd 2635 8 . . . cord-010119-t1x9gknd 2636 1 1 1 CD cord-010119-t1x9gknd 2636 2 Hemocentro Hemocentro NNP cord-010119-t1x9gknd 2636 3 Unicamp Unicamp NNP cord-010119-t1x9gknd 2636 4 , , , cord-010119-t1x9gknd 2636 5 2 2 CD cord-010119-t1x9gknd 2636 6 University University NNP cord-010119-t1x9gknd 2636 7 of of IN cord-010119-t1x9gknd 2636 8 Campinas Campinas NNP cord-010119-t1x9gknd 2636 9 Background Background NNP cord-010119-t1x9gknd 2636 10 / / SYM cord-010119-t1x9gknd 2636 11 Case Case NNP cord-010119-t1x9gknd 2636 12 Studies Studies NNPS cord-010119-t1x9gknd 2636 13 : : : cord-010119-t1x9gknd 2637 1 RBC RBC NNP cord-010119-t1x9gknd 2637 2 alloimmunization alloimmunization NN cord-010119-t1x9gknd 2637 3 has have VBZ cord-010119-t1x9gknd 2637 4 been be VBN cord-010119-t1x9gknd 2637 5 associated associate VBN cord-010119-t1x9gknd 2637 6 with with IN cord-010119-t1x9gknd 2637 7 several several JJ cord-010119-t1x9gknd 2637 8 factors factor NNS cord-010119-t1x9gknd 2637 9 and and CC cord-010119-t1x9gknd 2637 10 with with IN cord-010119-t1x9gknd 2637 11 individual individual JJ cord-010119-t1x9gknd 2637 12 characteristics characteristic NNS cord-010119-t1x9gknd 2637 13 of of IN cord-010119-t1x9gknd 2637 14 each each DT cord-010119-t1x9gknd 2637 15 patient patient NN cord-010119-t1x9gknd 2637 16 . . . cord-010119-t1x9gknd 2638 1 We -PRON- PRP cord-010119-t1x9gknd 2638 2 recently recently RB cord-010119-t1x9gknd 2638 3 found find VBD cord-010119-t1x9gknd 2638 4 that that IN cord-010119-t1x9gknd 2638 5 TNFA-308A tnfa-308a UH cord-010119-t1x9gknd 2638 6 , , , cord-010119-t1x9gknd 2638 7 IL1B-511 IL1B-511 NNP cord-010119-t1x9gknd 2638 8 T t NN cord-010119-t1x9gknd 2638 9 cytokine cytokine NN cord-010119-t1x9gknd 2638 10 polymorphisms polymorphism NNS cord-010119-t1x9gknd 2638 11 , , , cord-010119-t1x9gknd 2638 12 RHAG RHAG NNP cord-010119-t1x9gknd 2638 13 808 808 CD cord-010119-t1x9gknd 2638 14 G g NN cord-010119-t1x9gknd 2639 1 > > XX cord-010119-t1x9gknd 2640 1 A A NNP cord-010119-t1x9gknd 2640 2 and and CC cord-010119-t1x9gknd 2640 3 HLA HLA NNP cord-010119-t1x9gknd 2640 4 - - HYPH cord-010119-t1x9gknd 2640 5 DRB1 DRB1 NNP cord-010119-t1x9gknd 2641 1 * * NFP cord-010119-t1x9gknd 2641 2 15 15 CD cord-010119-t1x9gknd 2641 3 alleles allele NNS cord-010119-t1x9gknd 2641 4 may may MD cord-010119-t1x9gknd 2641 5 predict predict VB cord-010119-t1x9gknd 2641 6 a a DT cord-010119-t1x9gknd 2641 7 good good JJ cord-010119-t1x9gknd 2641 8 responder responder NN cord-010119-t1x9gknd 2641 9 phenotype phenotype NN cord-010119-t1x9gknd 2641 10 ( ( -LRB- cord-010119-t1x9gknd 2641 11 Sippert Sippert NNP cord-010119-t1x9gknd 2641 12 et et NNP cord-010119-t1x9gknd 2641 13 al al NNP cord-010119-t1x9gknd 2641 14 , , , cord-010119-t1x9gknd 2641 15 Transfusion Transfusion NNP cord-010119-t1x9gknd 2641 16 2017 2017 CD cord-010119-t1x9gknd 2641 17 ) ) -RRB- cord-010119-t1x9gknd 2641 18 and and CC cord-010119-t1x9gknd 2641 19 that that IN cord-010119-t1x9gknd 2641 20 RHAG RHAG NNP cord-010119-t1x9gknd 2641 21 808A 808A NNP cord-010119-t1x9gknd 2641 22 and and CC cord-010119-t1x9gknd 2641 23 HLA HLA NNP cord-010119-t1x9gknd 2641 24 - - HYPH cord-010119-t1x9gknd 2641 25 DRB*15 DRB*15 NNS cord-010119-t1x9gknd 2641 26 alleles allele NNS cord-010119-t1x9gknd 2641 27 are be VBP cord-010119-t1x9gknd 2641 28 closely closely RB cord-010119-t1x9gknd 2641 29 linked link VBN cord-010119-t1x9gknd 2641 30 to to IN cord-010119-t1x9gknd 2641 31 RH RH NNP cord-010119-t1x9gknd 2641 32 alloimmunization alloimmunization NN cord-010119-t1x9gknd 2641 33 . . . cord-010119-t1x9gknd 2642 1 Based base VBN cord-010119-t1x9gknd 2642 2 on on IN cord-010119-t1x9gknd 2642 3 this this DT cord-010119-t1x9gknd 2642 4 and and CC cord-010119-t1x9gknd 2642 5 considering consider VBG cord-010119-t1x9gknd 2642 6 the the DT cord-010119-t1x9gknd 2642 7 challenge challenge NN cord-010119-t1x9gknd 2642 8 to to TO cord-010119-t1x9gknd 2642 9 fulfill fulfill VB cord-010119-t1x9gknd 2642 10 the the DT cord-010119-t1x9gknd 2642 11 transfusion transfusion NN cord-010119-t1x9gknd 2642 12 needs need NNS cord-010119-t1x9gknd 2642 13 of of IN cord-010119-t1x9gknd 2642 14 the the DT cord-010119-t1x9gknd 2642 15 patients patient NNS cord-010119-t1x9gknd 2642 16 with with IN cord-010119-t1x9gknd 2642 17 RH RH NNP cord-010119-t1x9gknd 2642 18 variants variant NNS cord-010119-t1x9gknd 2642 19 , , , cord-010119-t1x9gknd 2642 20 we -PRON- PRP cord-010119-t1x9gknd 2642 21 used use VBD cord-010119-t1x9gknd 2642 22 these these DT cord-010119-t1x9gknd 2642 23 genetic genetic JJ cord-010119-t1x9gknd 2642 24 markers marker NNS cord-010119-t1x9gknd 2642 25 to to TO cord-010119-t1x9gknd 2642 26 select select VB cord-010119-t1x9gknd 2642 27 responders responder NNS cord-010119-t1x9gknd 2642 28 and and CC cord-010119-t1x9gknd 2642 29 nonresponders nonresponder VBZ cord-010119-t1x9gknd 2642 30 SCD SCD NNP cord-010119-t1x9gknd 2642 31 patients patient NNS cord-010119-t1x9gknd 2642 32 for for IN cord-010119-t1x9gknd 2642 33 transfusion transfusion NN cord-010119-t1x9gknd 2642 34 with with IN cord-010119-t1x9gknd 2642 35 RH RH NNP cord-010119-t1x9gknd 2642 36 haplotype haplotype NN cord-010119-t1x9gknd 2642 37 matching match VBG cord-010119-t1x9gknd 2642 38 RBC RBC NNP cord-010119-t1x9gknd 2642 39 units unit NNS cord-010119-t1x9gknd 2642 40 and and CC cord-010119-t1x9gknd 2642 41 evaluated evaluate VBD cord-010119-t1x9gknd 2642 42 the the DT cord-010119-t1x9gknd 2642 43 risk risk NN cord-010119-t1x9gknd 2642 44 of of IN cord-010119-t1x9gknd 2642 45 alloimmunization alloimmunization NN cord-010119-t1x9gknd 2642 46 . . . cord-010119-t1x9gknd 2643 1 Study Study NNP cord-010119-t1x9gknd 2643 2 Design Design NNP cord-010119-t1x9gknd 2643 3 / / SYM cord-010119-t1x9gknd 2643 4 Method method NN cord-010119-t1x9gknd 2643 5 : : : cord-010119-t1x9gknd 2644 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2644 2 study study NN cord-010119-t1x9gknd 2644 3 included include VBD cord-010119-t1x9gknd 2644 4 96 96 CD cord-010119-t1x9gknd 2644 5 non non JJ cord-010119-t1x9gknd 2644 6 - - JJ cord-010119-t1x9gknd 2644 7 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 2644 8 patients patient NNS cord-010119-t1x9gknd 2644 9 with with IN cord-010119-t1x9gknd 2644 10 SCD SCD NNP cord-010119-t1x9gknd 2644 11 , , , cord-010119-t1x9gknd 2644 12 homozygous homozygous JJ cord-010119-t1x9gknd 2644 13 for for IN cord-010119-t1x9gknd 2644 14 HbS HbS NNP cord-010119-t1x9gknd 2644 15 , , , cord-010119-t1x9gknd 2644 16 receiving receive VBG cord-010119-t1x9gknd 2644 17 a a DT cord-010119-t1x9gknd 2644 18 range range NN cord-010119-t1x9gknd 2644 19 of of IN cord-010119-t1x9gknd 2644 20 5 5 CD cord-010119-t1x9gknd 2644 21 - - SYM cord-010119-t1x9gknd 2644 22 289 289 CD cord-010119-t1x9gknd 2644 23 RBC RBC NNP cord-010119-t1x9gknd 2644 24 units unit NNS cord-010119-t1x9gknd 2644 25 . . . cord-010119-t1x9gknd 2645 1 RBC RBC NNP cord-010119-t1x9gknd 2645 2 antigen antigen NN cord-010119-t1x9gknd 2645 3 phenotypes phenotype NNS cord-010119-t1x9gknd 2645 4 of of IN cord-010119-t1x9gknd 2645 5 each each DT cord-010119-t1x9gknd 2645 6 patient patient NN cord-010119-t1x9gknd 2645 7 and and CC cord-010119-t1x9gknd 2645 8 history history NN cord-010119-t1x9gknd 2645 9 of of IN cord-010119-t1x9gknd 2645 10 RBC RBC NNP cord-010119-t1x9gknd 2645 11 antibodies antibody NNS cord-010119-t1x9gknd 2645 12 were be VBD cord-010119-t1x9gknd 2645 13 obtained obtain VBN cord-010119-t1x9gknd 2645 14 from from IN cord-010119-t1x9gknd 2645 15 the the DT cord-010119-t1x9gknd 2645 16 medical medical JJ cord-010119-t1x9gknd 2645 17 records record NNS cord-010119-t1x9gknd 2645 18 and and CC cord-010119-t1x9gknd 2645 19 transfusion transfusion NN cord-010119-t1x9gknd 2645 20 service service NN cord-010119-t1x9gknd 2645 21 computerized computerized NN cord-010119-t1x9gknd 2645 22 database database NN cord-010119-t1x9gknd 2645 23 . . . cord-010119-t1x9gknd 2646 1 RBC RBC NNP cord-010119-t1x9gknd 2646 2 genotyping genotyping NN cord-010119-t1x9gknd 2646 3 was be VBD cord-010119-t1x9gknd 2646 4 performed perform VBN cord-010119-t1x9gknd 2646 5 using use VBG cord-010119-t1x9gknd 2646 6 wHEA wHEA NNP cord-010119-t1x9gknd 2646 7 , , , cord-010119-t1x9gknd 2646 8 wRHD wRHD NNP cord-010119-t1x9gknd 2646 9 and and CC cord-010119-t1x9gknd 2646 10 wRHCE wRHCE NNP cord-010119-t1x9gknd 2646 11 BeadChip BeadChip NNP cord-010119-t1x9gknd 2646 12 arrays array NNS cord-010119-t1x9gknd 2646 13 ( ( -LRB- cord-010119-t1x9gknd 2646 14 BioArray BioArray NNP cord-010119-t1x9gknd 2646 15 Solutions Solutions NNPS cord-010119-t1x9gknd 2646 16 , , , cord-010119-t1x9gknd 2646 17 Immucor Immucor NNP cord-010119-t1x9gknd 2646 18 ) ) -RRB- cord-010119-t1x9gknd 2646 19 in in IN cord-010119-t1x9gknd 2646 20 accordance accordance NN cord-010119-t1x9gknd 2646 21 with with IN cord-010119-t1x9gknd 2646 22 the the DT cord-010119-t1x9gknd 2646 23 manufacturer manufacturer NN cord-010119-t1x9gknd 2646 24 's 's POS cord-010119-t1x9gknd 2646 25 instructions instruction NNS cord-010119-t1x9gknd 2646 26 . . . cord-010119-t1x9gknd 2647 1 Cytokine cytokine NN cord-010119-t1x9gknd 2647 2 gene gene NN cord-010119-t1x9gknd 2647 3 polymorphisms polymorphism NNS cord-010119-t1x9gknd 2647 4 ( ( -LRB- cord-010119-t1x9gknd 2647 5 TNFA-308 TNFA-308 NNP cord-010119-t1x9gknd 2647 6 G g NN cord-010119-t1x9gknd 2647 7 > > XX cord-010119-t1x9gknd 2648 1 A a LS cord-010119-t1x9gknd 2648 2 , , , cord-010119-t1x9gknd 2648 3 IL1B-511C IL1B-511C NNP cord-010119-t1x9gknd 2648 4 > > XX cord-010119-t1x9gknd 2648 5 T T NNP cord-010119-t1x9gknd 2648 6 ) ) -RRB- cord-010119-t1x9gknd 2648 7 and and CC cord-010119-t1x9gknd 2648 8 the the DT cord-010119-t1x9gknd 2648 9 RHAG RHAG NNP cord-010119-t1x9gknd 2648 10 808 808 CD cord-010119-t1x9gknd 2648 11 G g NN cord-010119-t1x9gknd 2649 1 > > XX cord-010119-t1x9gknd 2650 1 A a DT cord-010119-t1x9gknd 2650 2 gene gene NN cord-010119-t1x9gknd 2650 3 polymorphism polymorphism NN cord-010119-t1x9gknd 2650 4 were be VBD cord-010119-t1x9gknd 2650 5 analysed analyse VBN cord-010119-t1x9gknd 2650 6 by by IN cord-010119-t1x9gknd 2650 7 PCR PCR NNP cord-010119-t1x9gknd 2650 8 - - HYPH cord-010119-t1x9gknd 2650 9 RFLP RFLP NNP cord-010119-t1x9gknd 2650 10 and and CC cord-010119-t1x9gknd 2650 11 TaqMan TaqMan NNP cord-010119-t1x9gknd 2650 12 assays assay NNS cord-010119-t1x9gknd 2650 13 . . . cord-010119-t1x9gknd 2651 1 HLA HLA NNP cord-010119-t1x9gknd 2651 2 class class NN cord-010119-t1x9gknd 2651 3 II II NNP cord-010119-t1x9gknd 2651 4 genotyping genotyping NN cord-010119-t1x9gknd 2651 5 was be VBD cord-010119-t1x9gknd 2651 6 performed perform VBN cord-010119-t1x9gknd 2651 7 using use VBG cord-010119-t1x9gknd 2651 8 PCR PCR NNP cord-010119-t1x9gknd 2651 9 - - HYPH cord-010119-t1x9gknd 2651 10 SSO SSO NNP cord-010119-t1x9gknd 2651 11 . . . cord-010119-t1x9gknd 2652 1 Results/ Results/ . cord-010119-t1x9gknd 2653 1 Finding finding NN cord-010119-t1x9gknd 2653 2 : : : cord-010119-t1x9gknd 2654 1 Among among IN cord-010119-t1x9gknd 2654 2 96 96 CD cord-010119-t1x9gknd 2654 3 non non JJ cord-010119-t1x9gknd 2654 4 - - JJ cord-010119-t1x9gknd 2654 5 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 2654 6 patients patient NNS cord-010119-t1x9gknd 2654 7 , , , cord-010119-t1x9gknd 2654 8 21 21 CD cord-010119-t1x9gknd 2654 9 were be VBD cord-010119-t1x9gknd 2654 10 homozygous homozygous JJ cord-010119-t1x9gknd 2654 11 or or CC cord-010119-t1x9gknd 2654 12 compound compound JJ cord-010119-t1x9gknd 2654 13 heterozygous heterozygous JJ cord-010119-t1x9gknd 2654 14 for for IN cord-010119-t1x9gknd 2654 15 RH RH NNP cord-010119-t1x9gknd 2654 16 variant variant NN cord-010119-t1x9gknd 2654 17 alleles allele NNS cord-010119-t1x9gknd 2654 18 . . . cord-010119-t1x9gknd 2655 1 From from IN cord-010119-t1x9gknd 2655 2 those those DT cord-010119-t1x9gknd 2655 3 , , , cord-010119-t1x9gknd 2655 4 6 6 CD cord-010119-t1x9gknd 2655 5 had have VBD cord-010119-t1x9gknd 2655 6 RHAG RHAG NNP cord-010119-t1x9gknd 2655 7 808A 808a CD cord-010119-t1x9gknd 2656 1 and/or and/or CC cord-010119-t1x9gknd 2657 1 HLA HLA NNP cord-010119-t1x9gknd 2657 2 - - HYPH cord-010119-t1x9gknd 2657 3 DRB*15 DRB*15 NNP cord-010119-t1x9gknd 2657 4 alleles allele NNS cord-010119-t1x9gknd 2657 5 and and CC cord-010119-t1x9gknd 2657 6 at at RB cord-010119-t1x9gknd 2657 7 least least RBS cord-010119-t1x9gknd 2657 8 one one CD cord-010119-t1x9gknd 2657 9 cytokine cytokine NN cord-010119-t1x9gknd 2657 10 polymorphism polymorphism NN cord-010119-t1x9gknd 2657 11 ( ( -LRB- cord-010119-t1x9gknd 2657 12 TNFA-308A tnfa-308a UH cord-010119-t1x9gknd 2657 13 or or CC cord-010119-t1x9gknd 2657 14 ILB1 ILB1 NNP cord-010119-t1x9gknd 2657 15 - - HYPH cord-010119-t1x9gknd 2657 16 511 511 CD cord-010119-t1x9gknd 2657 17 T t NN cord-010119-t1x9gknd 2657 18 ) ) -RRB- cord-010119-t1x9gknd 2657 19 associated associate VBD cord-010119-t1x9gknd 2657 20 with with IN cord-010119-t1x9gknd 2657 21 risk risk NN cord-010119-t1x9gknd 2657 22 of of IN cord-010119-t1x9gknd 2657 23 alloimmunization alloimmunization NN cord-010119-t1x9gknd 2657 24 and and CC cord-010119-t1x9gknd 2657 25 were be VBD cord-010119-t1x9gknd 2657 26 transfused transfuse VBN cord-010119-t1x9gknd 2657 27 with with IN cord-010119-t1x9gknd 2657 28 extended extended JJ cord-010119-t1x9gknd 2657 29 and and CC cord-010119-t1x9gknd 2657 30 RH RH NNP cord-010119-t1x9gknd 2657 31 haplotype haplotype NN cord-010119-t1x9gknd 2657 32 matching match VBG cord-010119-t1x9gknd 2657 33 RBC RBC NNP cord-010119-t1x9gknd 2657 34 units unit NNS cord-010119-t1x9gknd 2657 35 . . . cord-010119-t1x9gknd 2658 1 The the DT cord-010119-t1x9gknd 2658 2 other other JJ cord-010119-t1x9gknd 2658 3 15 15 CD cord-010119-t1x9gknd 2658 4 patients patient NNS cord-010119-t1x9gknd 2658 5 with with IN cord-010119-t1x9gknd 2658 6 no no DT cord-010119-t1x9gknd 2658 7 risk risk NN cord-010119-t1x9gknd 2658 8 factors factor NNS cord-010119-t1x9gknd 2658 9 associated associate VBN cord-010119-t1x9gknd 2658 10 with with IN cord-010119-t1x9gknd 2658 11 RBC RBC NNP cord-010119-t1x9gknd 2658 12 alloimmunization alloimmunization NN cord-010119-t1x9gknd 2658 13 were be VBD cord-010119-t1x9gknd 2658 14 considered consider VBN cord-010119-t1x9gknd 2658 15 non non NNS cord-010119-t1x9gknd 2658 16 - - NNS cord-010119-t1x9gknd 2658 17 responders responder NNS cord-010119-t1x9gknd 2658 18 and and CC cord-010119-t1x9gknd 2658 19 were be VBD cord-010119-t1x9gknd 2658 20 not not RB cord-010119-t1x9gknd 2658 21 transfused transfuse VBN cord-010119-t1x9gknd 2658 22 with with IN cord-010119-t1x9gknd 2658 23 extended extended JJ cord-010119-t1x9gknd 2658 24 and and CC cord-010119-t1x9gknd 2658 25 RH RH NNP cord-010119-t1x9gknd 2658 26 matching matching NN cord-010119-t1x9gknd 2658 27 units unit NNS cord-010119-t1x9gknd 2658 28 . . . cord-010119-t1x9gknd 2659 1 All all DT cord-010119-t1x9gknd 2659 2 patients patient NNS cord-010119-t1x9gknd 2659 3 were be VBD cord-010119-t1x9gknd 2659 4 followed follow VBN cord-010119-t1x9gknd 2659 5 for for IN cord-010119-t1x9gknd 2659 6 one one CD cord-010119-t1x9gknd 2659 7 year year NN cord-010119-t1x9gknd 2659 8 and and CC cord-010119-t1x9gknd 2659 9 did do VBD cord-010119-t1x9gknd 2659 10 not not RB cord-010119-t1x9gknd 2659 11 develop develop VB cord-010119-t1x9gknd 2659 12 RBC RBC NNP cord-010119-t1x9gknd 2659 13 antibodies antibody NNS cord-010119-t1x9gknd 2659 14 . . . cord-010119-t1x9gknd 2660 1 Conclusion conclusion NN cord-010119-t1x9gknd 2660 2 : : : cord-010119-t1x9gknd 2661 1 These these DT cord-010119-t1x9gknd 2661 2 findings finding NNS cord-010119-t1x9gknd 2661 3 contributed contribute VBD cord-010119-t1x9gknd 2661 4 to to IN cord-010119-t1x9gknd 2661 5 the the DT cord-010119-t1x9gknd 2661 6 development development NN cord-010119-t1x9gknd 2661 7 of of IN cord-010119-t1x9gknd 2661 8 a a DT cord-010119-t1x9gknd 2661 9 transfusion transfusion NN cord-010119-t1x9gknd 2661 10 strategy strategy NN cord-010119-t1x9gknd 2661 11 for for IN cord-010119-t1x9gknd 2661 12 non non JJ cord-010119-t1x9gknd 2661 13 - - JJ cord-010119-t1x9gknd 2661 14 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 2661 15 SCD SCD NNP cord-010119-t1x9gknd 2661 16 patients patient NNS cord-010119-t1x9gknd 2661 17 as as IN cord-010119-t1x9gknd 2661 18 typing type VBG cord-010119-t1x9gknd 2661 19 for for IN cord-010119-t1x9gknd 2661 20 these these DT cord-010119-t1x9gknd 2661 21 polymorphisms polymorphism NNS cord-010119-t1x9gknd 2661 22 could could MD cord-010119-t1x9gknd 2661 23 potentially potentially RB cord-010119-t1x9gknd 2661 24 help help VB cord-010119-t1x9gknd 2661 25 in in IN cord-010119-t1x9gknd 2661 26 the the DT cord-010119-t1x9gknd 2661 27 classification classification NN cord-010119-t1x9gknd 2661 28 of of IN cord-010119-t1x9gknd 2661 29 responder responder NNP cord-010119-t1x9gknd 2661 30 and and CC cord-010119-t1x9gknd 2661 31 nonresponder nonresponder NNP cord-010119-t1x9gknd 2661 32 SCD SCD NNP cord-010119-t1x9gknd 2661 33 patients patient NNS cord-010119-t1x9gknd 2661 34 , , , cord-010119-t1x9gknd 2661 35 allowing allow VBG cord-010119-t1x9gknd 2661 36 blood blood NN cord-010119-t1x9gknd 2661 37 with with IN cord-010119-t1x9gknd 2661 38 high high JJ cord-010119-t1x9gknd 2661 39 level level NN cord-010119-t1x9gknd 2661 40 of of IN cord-010119-t1x9gknd 2661 41 compatibility compatibility NN cord-010119-t1x9gknd 2661 42 to to TO cord-010119-t1x9gknd 2661 43 be be VB cord-010119-t1x9gknd 2661 44 Five five CD cord-010119-t1x9gknd 2661 45 discrepant discrepant JJ cord-010119-t1x9gknd 2661 46 samples sample NNS cord-010119-t1x9gknd 2661 47 required require VBD cord-010119-t1x9gknd 2661 48 sequencing sequencing NN cord-010119-t1x9gknd 2661 49 . . . cord-010119-t1x9gknd 2662 1 ID ID NNP cord-010119-t1x9gknd 2662 2 CORE CORE NNP cord-010119-t1x9gknd 2662 3 XT XT NNP cord-010119-t1x9gknd 2662 4 identified identify VBD cord-010119-t1x9gknd 2662 5 three three CD cord-010119-t1x9gknd 2662 6 RHCE*ceAR rhce*cear JJ cord-010119-t1x9gknd 2662 7 samples sample NNS cord-010119-t1x9gknd 2662 8 encoding encode VBG cord-010119-t1x9gknd 2662 9 a a DT cord-010119-t1x9gknd 2662 10 partial partial JJ cord-010119-t1x9gknd 2662 11 c c NN cord-010119-t1x9gknd 2662 12 , , , cord-010119-t1x9gknd 2662 13 and and CC cord-010119-t1x9gknd 2662 14 a a DT cord-010119-t1x9gknd 2662 15 partial partial JJ cord-010119-t1x9gknd 2662 16 e e NN cord-010119-t1x9gknd 2662 17 ( ( -LRB- cord-010119-t1x9gknd 2662 18 predicted predict VBN cord-010119-t1x9gknd 2662 19 phenotype phenotype NN cord-010119-t1x9gknd 2662 20 : : : cord-010119-t1x9gknd 2662 21 Vweak Vweak NNP cord-010119-t1x9gknd 2662 22 , , , cord-010119-t1x9gknd 2662 23 VS- VS- NNP cord-010119-t1x9gknd 2662 24 ) ) -RRB- cord-010119-t1x9gknd 2662 25 and and CC cord-010119-t1x9gknd 2662 26 2 2 CD cord-010119-t1x9gknd 2662 27 were be VBD cord-010119-t1x9gknd 2662 28 confirmed confirm VBN cord-010119-t1x9gknd 2662 29 by by IN cord-010119-t1x9gknd 2662 30 sequencing sequence VBG cord-010119-t1x9gknd 2662 31 . . . cord-010119-t1x9gknd 2663 1 The the DT cord-010119-t1x9gknd 2663 2 third third JJ cord-010119-t1x9gknd 2663 3 sample sample NN cord-010119-t1x9gknd 2663 4 was be VBD cord-010119-t1x9gknd 2663 5 found find VBN cord-010119-t1x9gknd 2663 6 to to TO cord-010119-t1x9gknd 2663 7 be be VB cord-010119-t1x9gknd 2663 8 RHCE*ceVS.01,RHCE*ceBI RHCE*ceVS.01,RHCE*ceBI VBN cord-010119-t1x9gknd 2663 9 on on IN cord-010119-t1x9gknd 2663 10 sequencing sequencing NN cord-010119-t1x9gknd 2663 11 ( ( -LRB- cord-010119-t1x9gknd 2663 12 predicted predict VBN cord-010119-t1x9gknd 2663 13 phenotype phenotype NN cord-010119-t1x9gknd 2663 14 V1,VS1 V1,VS1 NNP cord-010119-t1x9gknd 2663 15 ) ) -RRB- cord-010119-t1x9gknd 2663 16 . . . cord-010119-t1x9gknd 2664 1 The the DT cord-010119-t1x9gknd 2664 2 3 3 CD cord-010119-t1x9gknd 2664 3 samples sample NNS cord-010119-t1x9gknd 2664 4 were be VBD cord-010119-t1x9gknd 2664 5 typed type VBN cord-010119-t1x9gknd 2664 6 as as IN cord-010119-t1x9gknd 2664 7 V1 V1 NNS cord-010119-t1x9gknd 2664 8 ( ( -LRB- cord-010119-t1x9gknd 2664 9 or or CC cord-010119-t1x9gknd 2664 10 ce ce NNP cord-010119-t1x9gknd 2664 11 S S NNP cord-010119-t1x9gknd 2664 12 ) ) -RRB- cord-010119-t1x9gknd 2664 13 and and CC cord-010119-t1x9gknd 2664 14 VS1 VS1 NNP cord-010119-t1x9gknd 2664 15 ( ( -LRB- cord-010119-t1x9gknd 2664 16 or or CC cord-010119-t1x9gknd 2664 17 e e NNP cord-010119-t1x9gknd 2664 18 S S NNP cord-010119-t1x9gknd 2664 19 ) ) -RRB- cord-010119-t1x9gknd 2664 20 by by IN cord-010119-t1x9gknd 2664 21 HEA HEA NNP cord-010119-t1x9gknd 2664 22 . . . cord-010119-t1x9gknd 2665 1 In in IN cord-010119-t1x9gknd 2665 2 addition addition NN cord-010119-t1x9gknd 2665 3 , , , cord-010119-t1x9gknd 2665 4 ID ID NNP cord-010119-t1x9gknd 2665 5 CORE CORE NNP cord-010119-t1x9gknd 2665 6 XT XT NNP cord-010119-t1x9gknd 2665 7 accurately accurately RB cord-010119-t1x9gknd 2665 8 identified identify VBD cord-010119-t1x9gknd 2665 9 RHCE*ce[712G]in RHCE*ce[712G]in NNP cord-010119-t1x9gknd 2665 10 2 2 CD cord-010119-t1x9gknd 2665 11 samples sample NNS cord-010119-t1x9gknd 2665 12 . . . cord-010119-t1x9gknd 2666 1 This this DT cord-010119-t1x9gknd 2666 2 SNP SNP NNP cord-010119-t1x9gknd 2666 3 has have VBZ cord-010119-t1x9gknd 2666 4 been be VBN cord-010119-t1x9gknd 2666 5 linked link VBN cord-010119-t1x9gknd 2666 6 to to IN cord-010119-t1x9gknd 2666 7 various various JJ cord-010119-t1x9gknd 2666 8 allelic allelic JJ cord-010119-t1x9gknd 2666 9 variants variant NNS cord-010119-t1x9gknd 2666 10 affecting affect VBG cord-010119-t1x9gknd 2666 11 c c NN cord-010119-t1x9gknd 2666 12 and and CC cord-010119-t1x9gknd 2666 13 e e LS cord-010119-t1x9gknd 2666 14 antigenic antigenic JJ cord-010119-t1x9gknd 2666 15 expression expression NN cord-010119-t1x9gknd 2666 16 . . . cord-010119-t1x9gknd 2667 1 Both both DT cord-010119-t1x9gknd 2667 2 samples sample NNS cord-010119-t1x9gknd 2667 3 were be VBD cord-010119-t1x9gknd 2667 4 predicted predict VBN cord-010119-t1x9gknd 2667 5 to to TO cord-010119-t1x9gknd 2667 6 be be VB cord-010119-t1x9gknd 2667 7 c1 c1 NNP cord-010119-t1x9gknd 2667 8 by by IN cord-010119-t1x9gknd 2667 9 HEA HEA NNP cord-010119-t1x9gknd 2667 10 . . . cord-010119-t1x9gknd 2668 1 Conclusion conclusion NN cord-010119-t1x9gknd 2668 2 : : : cord-010119-t1x9gknd 2668 3 Blood blood NN cord-010119-t1x9gknd 2668 4 group group NN cord-010119-t1x9gknd 2668 5 genotyping genotyping NN cord-010119-t1x9gknd 2668 6 platforms platform NNS cord-010119-t1x9gknd 2668 7 vary vary VBP cord-010119-t1x9gknd 2668 8 depending depend VBG cord-010119-t1x9gknd 2668 9 on on IN cord-010119-t1x9gknd 2668 10 the the DT cord-010119-t1x9gknd 2668 11 specific specific JJ cord-010119-t1x9gknd 2668 12 SNPs snp NNS cord-010119-t1x9gknd 2668 13 that that WDT cord-010119-t1x9gknd 2668 14 are be VBP cord-010119-t1x9gknd 2668 15 included include VBN cord-010119-t1x9gknd 2668 16 in in IN cord-010119-t1x9gknd 2668 17 each each DT cord-010119-t1x9gknd 2668 18 assay assay NN cord-010119-t1x9gknd 2668 19 . . . cord-010119-t1x9gknd 2669 1 Such such JJ cord-010119-t1x9gknd 2669 2 variations variation NNS cord-010119-t1x9gknd 2669 3 may may MD cord-010119-t1x9gknd 2669 4 be be VB cord-010119-t1x9gknd 2669 5 clinically clinically RB cord-010119-t1x9gknd 2669 6 significant significant JJ cord-010119-t1x9gknd 2669 7 when when WRB cord-010119-t1x9gknd 2669 8 genotyping genotyping NN cord-010119-t1x9gknd 2669 9 is be VBZ cord-010119-t1x9gknd 2669 10 used use VBN cord-010119-t1x9gknd 2669 11 as as IN cord-010119-t1x9gknd 2669 12 a a DT cord-010119-t1x9gknd 2669 13 tool tool NN cord-010119-t1x9gknd 2669 14 for for IN cord-010119-t1x9gknd 2669 15 providing provide VBG cord-010119-t1x9gknd 2669 16 matched match VBN cord-010119-t1x9gknd 2669 17 blood blood NN cord-010119-t1x9gknd 2669 18 . . . cord-010119-t1x9gknd 2670 1 Discrepancies discrepancy NNS cord-010119-t1x9gknd 2670 2 leading lead VBG cord-010119-t1x9gknd 2670 3 to to IN cord-010119-t1x9gknd 2670 4 differences difference NNS cord-010119-t1x9gknd 2670 5 in in IN cord-010119-t1x9gknd 2670 6 the the DT cord-010119-t1x9gknd 2670 7 predicted predict VBN cord-010119-t1x9gknd 2670 8 phenotype phenotype NN cord-010119-t1x9gknd 2670 9 could could MD cord-010119-t1x9gknd 2670 10 affect affect VB cord-010119-t1x9gknd 2670 11 unit unit NN cord-010119-t1x9gknd 2670 12 selection selection NN cord-010119-t1x9gknd 2670 13 . . . cord-010119-t1x9gknd 2671 1 Despite despite IN cord-010119-t1x9gknd 2671 2 the the DT cord-010119-t1x9gknd 2671 3 discrepancies discrepancy NNS cord-010119-t1x9gknd 2671 4 between between IN cord-010119-t1x9gknd 2671 5 the the DT cord-010119-t1x9gknd 2671 6 2 2 CD cord-010119-t1x9gknd 2671 7 methods method NNS cord-010119-t1x9gknd 2671 8 , , , cord-010119-t1x9gknd 2671 9 the the DT cord-010119-t1x9gknd 2671 10 high high JJ cord-010119-t1x9gknd 2671 11 concordance concordance NN cord-010119-t1x9gknd 2671 12 rate rate NN cord-010119-t1x9gknd 2671 13 and and CC cord-010119-t1x9gknd 2671 14 the the DT cord-010119-t1x9gknd 2671 15 limitations limitation NNS cord-010119-t1x9gknd 2671 16 of of IN cord-010119-t1x9gknd 2671 17 serology serology NN cord-010119-t1x9gknd 2671 18 warrant warrant VBP cord-010119-t1x9gknd 2671 19 further further JJ cord-010119-t1x9gknd 2671 20 reconsideration reconsideration NN cord-010119-t1x9gknd 2671 21 for for IN cord-010119-t1x9gknd 2671 22 the the DT cord-010119-t1x9gknd 2671 23 need need NN cord-010119-t1x9gknd 2671 24 for for IN cord-010119-t1x9gknd 2671 25 serologic serologic JJ cord-010119-t1x9gknd 2671 26 confirmation confirmation NN cord-010119-t1x9gknd 2671 27 of of IN cord-010119-t1x9gknd 2671 28 extended extended JJ cord-010119-t1x9gknd 2671 29 phenotypes phenotype NNS cord-010119-t1x9gknd 2671 30 . . . cord-010119-t1x9gknd 2672 1 Background Background NNP cord-010119-t1x9gknd 2672 2 / / SYM cord-010119-t1x9gknd 2672 3 Case Case NNP cord-010119-t1x9gknd 2672 4 Studies Studies NNPS cord-010119-t1x9gknd 2672 5 : : : cord-010119-t1x9gknd 2672 6 Over over IN cord-010119-t1x9gknd 2672 7 three three CD cord-010119-t1x9gknd 2672 8 decades decade NNS cord-010119-t1x9gknd 2672 9 ago ago RB cord-010119-t1x9gknd 2672 10 , , , cord-010119-t1x9gknd 2672 11 two two CD cord-010119-t1x9gknd 2672 12 independent independent JJ cord-010119-t1x9gknd 2672 13 groups group NNS cord-010119-t1x9gknd 2672 14 published publish VBN cord-010119-t1x9gknd 2672 15 work work NN cord-010119-t1x9gknd 2672 16 suggesting suggest VBG cord-010119-t1x9gknd 2672 17 a a DT cord-010119-t1x9gknd 2672 18 novel novel JJ cord-010119-t1x9gknd 2672 19 categorization categorization NN cord-010119-t1x9gknd 2672 20 of of IN cord-010119-t1x9gknd 2672 21 warm warm JJ cord-010119-t1x9gknd 2672 22 autoimmune autoimmune JJ cord-010119-t1x9gknd 2672 23 hemolytic hemolytic JJ cord-010119-t1x9gknd 2672 24 anemia anemia NN cord-010119-t1x9gknd 2672 25 ( ( -LRB- cord-010119-t1x9gknd 2672 26 wAIHA waiha NN cord-010119-t1x9gknd 2672 27 ) ) -RRB- cord-010119-t1x9gknd 2672 28 on on IN cord-010119-t1x9gknd 2672 29 the the DT cord-010119-t1x9gknd 2672 30 basis basis NN cord-010119-t1x9gknd 2672 31 of of IN cord-010119-t1x9gknd 2672 32 DAT DAT NNP cord-010119-t1x9gknd 2672 33 scores score NNS cord-010119-t1x9gknd 2672 34 of of IN cord-010119-t1x9gknd 2672 35 agefractionated agefractionate VBN cord-010119-t1x9gknd 2672 36 RBCs rbc NNS cord-010119-t1x9gknd 2672 37 : : : cord-010119-t1x9gknd 2673 1 Type type NN cord-010119-t1x9gknd 2673 2 I -PRON- PRP cord-010119-t1x9gknd 2673 3 wAIHA waiha VBP cord-010119-t1x9gknd 2673 4 , , , cord-010119-t1x9gknd 2673 5 comprising comprise VBG cord-010119-t1x9gknd 2673 6 80 80 CD cord-010119-t1x9gknd 2673 7 % % NN cord-010119-t1x9gknd 2673 8 of of IN cord-010119-t1x9gknd 2673 9 patients patient NNS cord-010119-t1x9gknd 2673 10 , , , cord-010119-t1x9gknd 2673 11 showed show VBD cord-010119-t1x9gknd 2673 12 increased increase VBN cord-010119-t1x9gknd 2673 13 binding binding NN cord-010119-t1x9gknd 2673 14 of of IN cord-010119-t1x9gknd 2673 15 autoantibodies autoantibody NNS cord-010119-t1x9gknd 2673 16 to to IN cord-010119-t1x9gknd 2673 17 aged age VBN cord-010119-t1x9gknd 2673 18 RBC RBC NNP cord-010119-t1x9gknd 2673 19 , , , cord-010119-t1x9gknd 2673 20 whereas whereas IN cord-010119-t1x9gknd 2673 21 Type Type NNP cord-010119-t1x9gknd 2673 22 II II NNP cord-010119-t1x9gknd 2673 23 wAIHA waiha NN cord-010119-t1x9gknd 2673 24 autoantibodies autoantibody NNS cord-010119-t1x9gknd 2673 25 ( ( -LRB- cord-010119-t1x9gknd 2673 26 20 20 CD cord-010119-t1x9gknd 2673 27 % % NN cord-010119-t1x9gknd 2673 28 of of IN cord-010119-t1x9gknd 2673 29 patients patient NNS cord-010119-t1x9gknd 2673 30 ) ) -RRB- cord-010119-t1x9gknd 2673 31 bound bind VBN cord-010119-t1x9gknd 2673 32 young young JJ cord-010119-t1x9gknd 2673 33 and and CC cord-010119-t1x9gknd 2673 34 old old JJ cord-010119-t1x9gknd 2673 35 RBCs rbc NNS cord-010119-t1x9gknd 2673 36 with with IN cord-010119-t1x9gknd 2673 37 no no DT cord-010119-t1x9gknd 2673 38 apparent apparent JJ cord-010119-t1x9gknd 2673 39 prejudice prejudice NN cord-010119-t1x9gknd 2673 40 . . . cord-010119-t1x9gknd 2674 1 Band-3 Band-3 NNP cord-010119-t1x9gknd 2674 2 is be VBZ cord-010119-t1x9gknd 2674 3 a a DT cord-010119-t1x9gknd 2674 4 ubiquitously ubiquitously RB cord-010119-t1x9gknd 2674 5 expressed express VBN cord-010119-t1x9gknd 2674 6 RBC RBC NNP cord-010119-t1x9gknd 2674 7 transmembrane transmembrane NN cord-010119-t1x9gknd 2674 8 protein protein NN cord-010119-t1x9gknd 2674 9 which which WDT cord-010119-t1x9gknd 2674 10 plays play VBZ cord-010119-t1x9gknd 2674 11 a a DT cord-010119-t1x9gknd 2674 12 vital vital JJ cord-010119-t1x9gknd 2674 13 role role NN cord-010119-t1x9gknd 2674 14 in in IN cord-010119-t1x9gknd 2674 15 maintenance maintenance NN cord-010119-t1x9gknd 2674 16 of of IN cord-010119-t1x9gknd 2674 17 RBC RBC NNP cord-010119-t1x9gknd 2674 18 structural structural JJ cord-010119-t1x9gknd 2674 19 integrity integrity NN cord-010119-t1x9gknd 2674 20 , , , cord-010119-t1x9gknd 2674 21 cellular cellular JJ cord-010119-t1x9gknd 2674 22 hemostasis hemostasis NN cord-010119-t1x9gknd 2674 23 , , , cord-010119-t1x9gknd 2674 24 and and CC cord-010119-t1x9gknd 2674 25 regulation regulation NN cord-010119-t1x9gknd 2674 26 of of IN cord-010119-t1x9gknd 2674 27 senescence senescence NN cord-010119-t1x9gknd 2674 28 ; ; : cord-010119-t1x9gknd 2674 29 and and CC cord-010119-t1x9gknd 2674 30 , , , cord-010119-t1x9gknd 2674 31 has have VBZ cord-010119-t1x9gknd 2674 32 been be VBN cord-010119-t1x9gknd 2674 33 suggested suggest VBN cord-010119-t1x9gknd 2674 34 to to TO cord-010119-t1x9gknd 2674 35 be be VB cord-010119-t1x9gknd 2674 36 targeted target VBN cord-010119-t1x9gknd 2674 37 by by IN cord-010119-t1x9gknd 2674 38 autoantibodies autoantibody NNS cord-010119-t1x9gknd 2674 39 from from IN cord-010119-t1x9gknd 2674 40 patients patient NNS cord-010119-t1x9gknd 2674 41 with with IN cord-010119-t1x9gknd 2674 42 wAIHA waiha NN cord-010119-t1x9gknd 2674 43 . . . cord-010119-t1x9gknd 2675 1 Band-3 Band-3 NNP cord-010119-t1x9gknd 2675 2 is be VBZ cord-010119-t1x9gknd 2675 3 regulated regulate VBN cord-010119-t1x9gknd 2675 4 through through IN cord-010119-t1x9gknd 2675 5 phosphorylation phosphorylation NN cord-010119-t1x9gknd 2675 6 of of IN cord-010119-t1x9gknd 2675 7 key key JJ cord-010119-t1x9gknd 2675 8 residues residue NNS cord-010119-t1x9gknd 2675 9 ; ; : cord-010119-t1x9gknd 2675 10 its -PRON- PRP$ cord-010119-t1x9gknd 2675 11 hyperphosphorylation hyperphosphorylation NN cord-010119-t1x9gknd 2675 12 is be VBZ cord-010119-t1x9gknd 2675 13 a a DT cord-010119-t1x9gknd 2675 14 hallmark hallmark NN cord-010119-t1x9gknd 2675 15 of of IN cord-010119-t1x9gknd 2675 16 normal normal JJ cord-010119-t1x9gknd 2675 17 RBC RBC NNP cord-010119-t1x9gknd 2675 18 senescence senescence NN cord-010119-t1x9gknd 2675 19 , , , cord-010119-t1x9gknd 2675 20 which which WDT cord-010119-t1x9gknd 2675 21 causes cause VBZ cord-010119-t1x9gknd 2675 22 band-3 band-3 NNP cord-010119-t1x9gknd 2675 23 to to TO cord-010119-t1x9gknd 2675 24 disengage disengage VB cord-010119-t1x9gknd 2675 25 from from IN cord-010119-t1x9gknd 2675 26 the the DT cord-010119-t1x9gknd 2675 27 cytoskeleton cytoskeleton NN cord-010119-t1x9gknd 2675 28 , , , cord-010119-t1x9gknd 2675 29 increasing increase VBG cord-010119-t1x9gknd 2675 30 its -PRON- PRP$ cord-010119-t1x9gknd 2675 31 lateral lateral JJ cord-010119-t1x9gknd 2675 32 diffusion diffusion NN cord-010119-t1x9gknd 2675 33 , , , cord-010119-t1x9gknd 2675 34 thereby thereby RB cord-010119-t1x9gknd 2675 35 permitting permit VBG cord-010119-t1x9gknd 2675 36 the the DT cord-010119-t1x9gknd 2675 37 formation formation NN cord-010119-t1x9gknd 2675 38 of of IN cord-010119-t1x9gknd 2675 39 band-3 band-3 NNP cord-010119-t1x9gknd 2675 40 aggregates aggregate NNS cord-010119-t1x9gknd 2675 41 forming form VBG cord-010119-t1x9gknd 2675 42 new new JJ cord-010119-t1x9gknd 2675 43 epitopes epitope NNS cord-010119-t1x9gknd 2675 44 which which WDT cord-010119-t1x9gknd 2675 45 are be VBP cord-010119-t1x9gknd 2675 46 recognized recognize VBN cord-010119-t1x9gknd 2675 47 by by IN cord-010119-t1x9gknd 2675 48 natural natural JJ cord-010119-t1x9gknd 2675 49 IgG IgG NNP cord-010119-t1x9gknd 2675 50 autoantibodies autoantibody NNS cord-010119-t1x9gknd 2675 51 causing cause VBG cord-010119-t1x9gknd 2675 52 phagocytosis phagocytosis NN cord-010119-t1x9gknd 2675 53 and and CC cord-010119-t1x9gknd 2675 54 destruction destruction NN cord-010119-t1x9gknd 2675 55 of of IN cord-010119-t1x9gknd 2675 56 senescent senescent JJ cord-010119-t1x9gknd 2675 57 RBCs rbc NNS cord-010119-t1x9gknd 2675 58 . . . cord-010119-t1x9gknd 2676 1 Type type NN cord-010119-t1x9gknd 2677 1 I -PRON- PRP cord-010119-t1x9gknd 2677 2 wAIHA waiha VBP cord-010119-t1x9gknd 2677 3 has have VBZ cord-010119-t1x9gknd 2677 4 been be VBN cord-010119-t1x9gknd 2677 5 postulated postulate VBN cord-010119-t1x9gknd 2677 6 to to TO cord-010119-t1x9gknd 2677 7 be be VB cord-010119-t1x9gknd 2677 8 caused cause VBN cord-010119-t1x9gknd 2677 9 by by IN cord-010119-t1x9gknd 2677 10 an an DT cord-010119-t1x9gknd 2677 11 exacerbation exacerbation NN cord-010119-t1x9gknd 2677 12 of of IN cord-010119-t1x9gknd 2677 13 normal normal JJ cord-010119-t1x9gknd 2677 14 RBC RBC NNP cord-010119-t1x9gknd 2677 15 senescence senescence NN cord-010119-t1x9gknd 2677 16 . . . cord-010119-t1x9gknd 2678 1 Study Study NNP cord-010119-t1x9gknd 2678 2 Design Design NNP cord-010119-t1x9gknd 2678 3 / / SYM cord-010119-t1x9gknd 2678 4 Methods method NNS cord-010119-t1x9gknd 2678 5 : : : cord-010119-t1x9gknd 2679 1 In in IN cord-010119-t1x9gknd 2679 2 an an DT cord-010119-t1x9gknd 2679 3 effort effort NN cord-010119-t1x9gknd 2679 4 to to TO cord-010119-t1x9gknd 2679 5 confirm confirm VB cord-010119-t1x9gknd 2679 6 and and CC cord-010119-t1x9gknd 2679 7 characterize characterize VB cord-010119-t1x9gknd 2679 8 the the DT cord-010119-t1x9gknd 2679 9 two two CD cord-010119-t1x9gknd 2679 10 wAIHA waiha NN cord-010119-t1x9gknd 2679 11 subtypes subtype NNS cord-010119-t1x9gknd 2679 12 we -PRON- PRP cord-010119-t1x9gknd 2679 13 age age NN cord-010119-t1x9gknd 2679 14 - - HYPH cord-010119-t1x9gknd 2679 15 fractionated fractionate VBN cord-010119-t1x9gknd 2679 16 whole whole JJ cord-010119-t1x9gknd 2679 17 blood blood NN cord-010119-t1x9gknd 2679 18 samples sample NNS cord-010119-t1x9gknd 2679 19 from from IN cord-010119-t1x9gknd 2679 20 22 22 CD cord-010119-t1x9gknd 2679 21 patients patient NNS cord-010119-t1x9gknd 2679 22 with with IN cord-010119-t1x9gknd 2679 23 wAIHA waiha NN cord-010119-t1x9gknd 2679 24 on on IN cord-010119-t1x9gknd 2679 25 discontinuous discontinuous JJ cord-010119-t1x9gknd 2679 26 PercollV PercollV NNP cord-010119-t1x9gknd 2679 27 R r NN cord-010119-t1x9gknd 2679 28 gradients gradient NNS cord-010119-t1x9gknd 2679 29 and and CC cord-010119-t1x9gknd 2679 30 looked look VBD cord-010119-t1x9gknd 2679 31 for for IN cord-010119-t1x9gknd 2679 32 differences difference NNS cord-010119-t1x9gknd 2679 33 in in IN cord-010119-t1x9gknd 2679 34 DAT DAT NNP cord-010119-t1x9gknd 2679 35 results result VBZ cord-010119-t1x9gknd 2679 36 between between IN cord-010119-t1x9gknd 2679 37 less less RBR cord-010119-t1x9gknd 2679 38 ( ( -LRB- cord-010119-t1x9gknd 2679 39 young young JJ cord-010119-t1x9gknd 2679 40 RBCs rbc NNS cord-010119-t1x9gknd 2679 41 ) ) -RRB- cord-010119-t1x9gknd 2679 42 and and CC cord-010119-t1x9gknd 2679 43 more more RBR cord-010119-t1x9gknd 2679 44 dense dense JJ cord-010119-t1x9gknd 2679 45 ( ( -LRB- cord-010119-t1x9gknd 2679 46 aged aged JJ cord-010119-t1x9gknd 2679 47 RBCs rbc NNS cord-010119-t1x9gknd 2679 48 ) ) -RRB- cord-010119-t1x9gknd 2679 49 fractions fraction NNS cord-010119-t1x9gknd 2679 50 , , , cord-010119-t1x9gknd 2679 51 fractionation fractionation NN cord-010119-t1x9gknd 2679 52 patterns pattern NNS cord-010119-t1x9gknd 2679 53 and and CC cord-010119-t1x9gknd 2679 54 band-3 band-3 IN cord-010119-t1x9gknd 2679 55 tyrosine tyrosine NN cord-010119-t1x9gknd 2679 56 phosphorylation phosphorylation NN cord-010119-t1x9gknd 2679 57 . . . cord-010119-t1x9gknd 2680 1 Results result NNS cord-010119-t1x9gknd 2680 2 / / SYM cord-010119-t1x9gknd 2680 3 Findings finding NNS cord-010119-t1x9gknd 2680 4 : : : cord-010119-t1x9gknd 2681 1 We -PRON- PRP cord-010119-t1x9gknd 2681 2 confirm confirm VBP cord-010119-t1x9gknd 2681 3 that that IN cord-010119-t1x9gknd 2681 4 two two CD cord-010119-t1x9gknd 2681 5 distinct distinct JJ cord-010119-t1x9gknd 2681 6 types type NNS cord-010119-t1x9gknd 2681 7 of of IN cord-010119-t1x9gknd 2681 8 wAIHA waiha NN cord-010119-t1x9gknd 2681 9 can can MD cord-010119-t1x9gknd 2681 10 be be VB cord-010119-t1x9gknd 2681 11 identified identify VBN cord-010119-t1x9gknd 2681 12 based base VBN cord-010119-t1x9gknd 2681 13 on on IN cord-010119-t1x9gknd 2681 14 autoantibody autoantibody NNP cord-010119-t1x9gknd 2681 15 reactivity reactivity NN cord-010119-t1x9gknd 2681 16 with with IN cord-010119-t1x9gknd 2681 17 the the DT cord-010119-t1x9gknd 2681 18 youngest young JJS cord-010119-t1x9gknd 2681 19 and and CC cord-010119-t1x9gknd 2681 20 oldest old JJS cord-010119-t1x9gknd 2681 21 autologous autologous JJ cord-010119-t1x9gknd 2681 22 RBCs rbc NNS cord-010119-t1x9gknd 2681 23 . . . cord-010119-t1x9gknd 2682 1 Further further RB cord-010119-t1x9gknd 2682 2 , , , cord-010119-t1x9gknd 2682 3 comparing compare VBG cord-010119-t1x9gknd 2682 4 5 5 CD cord-010119-t1x9gknd 2682 5 Type type NN cord-010119-t1x9gknd 2682 6 I i NN cord-010119-t1x9gknd 2682 7 and and CC cord-010119-t1x9gknd 2682 8 5 5 CD cord-010119-t1x9gknd 2682 9 Type Type NNP cord-010119-t1x9gknd 2682 10 II II NNP cord-010119-t1x9gknd 2682 11 patients patient NNS cord-010119-t1x9gknd 2682 12 , , , cord-010119-t1x9gknd 2682 13 we -PRON- PRP cord-010119-t1x9gknd 2682 14 found find VBD cord-010119-t1x9gknd 2682 15 that that IN cord-010119-t1x9gknd 2682 16 Type type NN cord-010119-t1x9gknd 2682 17 I -PRON- PRP cord-010119-t1x9gknd 2682 18 is be VBZ cord-010119-t1x9gknd 2682 19 characterized characterize VBN cord-010119-t1x9gknd 2682 20 by by IN cord-010119-t1x9gknd 2682 21 5 5 CD cord-010119-t1x9gknd 2682 22 PercollV PercollV NNP cord-010119-t1x9gknd 2682 23 R r NN cord-010119-t1x9gknd 2682 24 fractions fraction NNS cord-010119-t1x9gknd 2682 25 ( ( -LRB- cord-010119-t1x9gknd 2682 26 similar similar JJ cord-010119-t1x9gknd 2682 27 to to IN cord-010119-t1x9gknd 2682 28 healthy healthy JJ cord-010119-t1x9gknd 2682 29 storage storage NN cord-010119-t1x9gknd 2682 30 - - HYPH cord-010119-t1x9gknd 2682 31 matched match VBN cord-010119-t1x9gknd 2682 32 controls control NNS cord-010119-t1x9gknd 2682 33 ) ) -RRB- cord-010119-t1x9gknd 2682 34 but but CC cord-010119-t1x9gknd 2682 35 increased increase VBN cord-010119-t1x9gknd 2682 36 band-3 band-3 IN cord-010119-t1x9gknd 2682 37 tyrosine tyrosine NN cord-010119-t1x9gknd 2682 38 phosphorylation phosphorylation NN cord-010119-t1x9gknd 2682 39 compared compare VBN cord-010119-t1x9gknd 2682 40 to to IN cord-010119-t1x9gknd 2682 41 healthy healthy JJ cord-010119-t1x9gknd 2682 42 storage storage NN cord-010119-t1x9gknd 2682 43 - - HYPH cord-010119-t1x9gknd 2682 44 matched match VBN cord-010119-t1x9gknd 2682 45 controls control NNS cord-010119-t1x9gknd 2682 46 , , , cord-010119-t1x9gknd 2682 47 with with IN cord-010119-t1x9gknd 2682 48 phosphorylation phosphorylation NN cord-010119-t1x9gknd 2682 49 occurring occur VBG cord-010119-t1x9gknd 2682 50 during during IN cord-010119-t1x9gknd 2682 51 younger young JJR cord-010119-t1x9gknd 2682 52 stages stage NNS cord-010119-t1x9gknd 2682 53 of of IN cord-010119-t1x9gknd 2682 54 RBC RBC NNP cord-010119-t1x9gknd 2682 55 development development NN cord-010119-t1x9gknd 2682 56 . . . cord-010119-t1x9gknd 2683 1 Type Type NNP cord-010119-t1x9gknd 2683 2 II ii CD cord-010119-t1x9gknd 2683 3 patients patient NNS cord-010119-t1x9gknd 2683 4 were be VBD cord-010119-t1x9gknd 2683 5 characterized characterize VBN cord-010119-t1x9gknd 2683 6 by by IN cord-010119-t1x9gknd 2683 7 3 3 CD cord-010119-t1x9gknd 2683 8 - - SYM cord-010119-t1x9gknd 2683 9 4 4 CD cord-010119-t1x9gknd 2683 10 PercollV PercollV NNP cord-010119-t1x9gknd 2683 11 R r NN cord-010119-t1x9gknd 2683 12 fractions fraction NNS cord-010119-t1x9gknd 2683 13 , , , cord-010119-t1x9gknd 2683 14 lacking lack VBG cord-010119-t1x9gknd 2683 15 the the DT cord-010119-t1x9gknd 2683 16 fraction fraction NN cord-010119-t1x9gknd 2683 17 containing contain VBG cord-010119-t1x9gknd 2683 18 the the DT cord-010119-t1x9gknd 2683 19 oldest old JJS cord-010119-t1x9gknd 2683 20 RBCs rbc NNS cord-010119-t1x9gknd 2683 21 , , , cord-010119-t1x9gknd 2683 22 and and CC cord-010119-t1x9gknd 2683 23 showed show VBD cord-010119-t1x9gknd 2683 24 a a DT cord-010119-t1x9gknd 2683 25 complete complete JJ cord-010119-t1x9gknd 2683 26 lack lack NN cord-010119-t1x9gknd 2683 27 of of IN cord-010119-t1x9gknd 2683 28 , , , cord-010119-t1x9gknd 2683 29 or or CC cord-010119-t1x9gknd 2683 30 dramatic dramatic JJ cord-010119-t1x9gknd 2683 31 decrease decrease NN cord-010119-t1x9gknd 2683 32 in in IN cord-010119-t1x9gknd 2683 33 , , , cord-010119-t1x9gknd 2683 34 band-3 band-3 IN cord-010119-t1x9gknd 2683 35 tyrosine tyrosine NN cord-010119-t1x9gknd 2683 36 phosphorylation phosphorylation NN cord-010119-t1x9gknd 2683 37 compared compare VBN cord-010119-t1x9gknd 2683 38 to to IN cord-010119-t1x9gknd 2683 39 healthy healthy JJ cord-010119-t1x9gknd 2683 40 storage storage NN cord-010119-t1x9gknd 2683 41 - - HYPH cord-010119-t1x9gknd 2683 42 matched match VBN cord-010119-t1x9gknd 2683 43 controls control NNS cord-010119-t1x9gknd 2683 44 . . . cord-010119-t1x9gknd 2684 1 Conclusion conclusion NN cord-010119-t1x9gknd 2684 2 : : : cord-010119-t1x9gknd 2685 1 These these DT cord-010119-t1x9gknd 2685 2 results result NNS cord-010119-t1x9gknd 2685 3 confirm confirm VBP cord-010119-t1x9gknd 2685 4 the the DT cord-010119-t1x9gknd 2685 5 two two CD cord-010119-t1x9gknd 2685 6 distinct distinct JJ cord-010119-t1x9gknd 2685 7 types type NNS cord-010119-t1x9gknd 2685 8 of of IN cord-010119-t1x9gknd 2685 9 wAIHA waiha NN cord-010119-t1x9gknd 2685 10 . . . cord-010119-t1x9gknd 2686 1 In in IN cord-010119-t1x9gknd 2686 2 Type type NN cord-010119-t1x9gknd 2687 1 I -PRON- PRP cord-010119-t1x9gknd 2687 2 wAIHA waiha VBP cord-010119-t1x9gknd 2687 3 , , , cord-010119-t1x9gknd 2688 1 the the DT cord-010119-t1x9gknd 2688 2 increased increase VBN cord-010119-t1x9gknd 2688 3 binding binding NN cord-010119-t1x9gknd 2688 4 of of IN cord-010119-t1x9gknd 2688 5 autoantibodies autoantibody NNS cord-010119-t1x9gknd 2688 6 to to IN cord-010119-t1x9gknd 2688 7 older old JJR cord-010119-t1x9gknd 2688 8 RBCs rbc NNS cord-010119-t1x9gknd 2688 9 coupled couple VBN cord-010119-t1x9gknd 2688 10 with with IN cord-010119-t1x9gknd 2688 11 increased increase VBN cord-010119-t1x9gknd 2688 12 tyrosine tyrosine NN cord-010119-t1x9gknd 2688 13 phosphorylation phosphorylation NN cord-010119-t1x9gknd 2688 14 of of IN cord-010119-t1x9gknd 2688 15 band-3 band-3 NNP cord-010119-t1x9gknd 2688 16 suggests suggest VBZ cord-010119-t1x9gknd 2688 17 that that IN cord-010119-t1x9gknd 2688 18 RBCs rbc NNS cord-010119-t1x9gknd 2688 19 from from IN cord-010119-t1x9gknd 2688 20 Type type NN cord-010119-t1x9gknd 2688 21 I -PRON- PRP cord-010119-t1x9gknd 2688 22 patients patient NNS cord-010119-t1x9gknd 2688 23 are be VBP cord-010119-t1x9gknd 2688 24 aging age VBG cord-010119-t1x9gknd 2688 25 faster fast RBR cord-010119-t1x9gknd 2688 26 than than IN cord-010119-t1x9gknd 2688 27 RBCs rbc NNS cord-010119-t1x9gknd 2688 28 from from IN cord-010119-t1x9gknd 2688 29 normal normal JJ cord-010119-t1x9gknd 2688 30 healthy healthy JJ cord-010119-t1x9gknd 2688 31 controls control NNS cord-010119-t1x9gknd 2688 32 ; ; : cord-010119-t1x9gknd 2688 33 this this DT cord-010119-t1x9gknd 2688 34 may may MD cord-010119-t1x9gknd 2688 35 represent represent VB cord-010119-t1x9gknd 2688 36 an an DT cord-010119-t1x9gknd 2688 37 accelerated accelerated JJ cord-010119-t1x9gknd 2688 38 and and CC cord-010119-t1x9gknd 2688 39 pathogenic pathogenic JJ cord-010119-t1x9gknd 2688 40 form form NN cord-010119-t1x9gknd 2688 41 of of IN cord-010119-t1x9gknd 2688 42 normal normal JJ cord-010119-t1x9gknd 2688 43 RBC RBC NNP cord-010119-t1x9gknd 2688 44 senescence senescence NN cord-010119-t1x9gknd 2688 45 . . . cord-010119-t1x9gknd 2689 1 In in IN cord-010119-t1x9gknd 2689 2 contrast contrast NN cord-010119-t1x9gknd 2689 3 , , , cord-010119-t1x9gknd 2689 4 Type Type NNP cord-010119-t1x9gknd 2689 5 II II NNP cord-010119-t1x9gknd 2689 6 wAIHA waiha NN cord-010119-t1x9gknd 2689 7 where where WRB cord-010119-t1x9gknd 2689 8 autoantibodies autoantibody NNS cord-010119-t1x9gknd 2689 9 bind bind VBP cord-010119-t1x9gknd 2689 10 strongly strongly RB cord-010119-t1x9gknd 2689 11 to to IN cord-010119-t1x9gknd 2689 12 either either CC cord-010119-t1x9gknd 2689 13 young young JJ cord-010119-t1x9gknd 2689 14 or or CC cord-010119-t1x9gknd 2689 15 old old JJ cord-010119-t1x9gknd 2689 16 RBCs rbc NNS cord-010119-t1x9gknd 2689 17 coupled couple VBN cord-010119-t1x9gknd 2689 18 with with IN cord-010119-t1x9gknd 2689 19 a a DT cord-010119-t1x9gknd 2689 20 lack lack NN cord-010119-t1x9gknd 2689 21 of of IN cord-010119-t1x9gknd 2689 22 fractionated fractionated JJ cord-010119-t1x9gknd 2689 23 bands band NNS cord-010119-t1x9gknd 2689 24 that that WDT cord-010119-t1x9gknd 2689 25 represent represent VBP cord-010119-t1x9gknd 2689 26 the the DT cord-010119-t1x9gknd 2689 27 oldest old JJS cord-010119-t1x9gknd 2689 28 RBCs rbc NNS cord-010119-t1x9gknd 2689 29 and and CC cord-010119-t1x9gknd 2689 30 a a DT cord-010119-t1x9gknd 2689 31 dramatic dramatic JJ cord-010119-t1x9gknd 2689 32 diminution diminution NN cord-010119-t1x9gknd 2689 33 in in IN cord-010119-t1x9gknd 2689 34 tyrosine tyrosine NN cord-010119-t1x9gknd 2689 35 phosphorylation phosphorylation NN cord-010119-t1x9gknd 2689 36 of of IN cord-010119-t1x9gknd 2689 37 band band NN cord-010119-t1x9gknd 2689 38 3 3 CD cord-010119-t1x9gknd 2689 39 suggests suggest VBZ cord-010119-t1x9gknd 2689 40 faster fast JJR cord-010119-t1x9gknd 2689 41 destruction destruction NN cord-010119-t1x9gknd 2689 42 of of IN cord-010119-t1x9gknd 2689 43 RBCs rbc NNS cord-010119-t1x9gknd 2689 44 , , , cord-010119-t1x9gknd 2689 45 consistent consistent JJ cord-010119-t1x9gknd 2689 46 with with IN cord-010119-t1x9gknd 2689 47 the the DT cord-010119-t1x9gknd 2689 48 early early JJ cord-010119-t1x9gknd 2689 49 published publish VBN cord-010119-t1x9gknd 2689 50 data datum NNS cord-010119-t1x9gknd 2689 51 , , , cord-010119-t1x9gknd 2689 52 and and CC cord-010119-t1x9gknd 2689 53 metabolic metabolic JJ cord-010119-t1x9gknd 2689 54 changes change NNS cord-010119-t1x9gknd 2689 55 that that WDT cord-010119-t1x9gknd 2689 56 could could MD cord-010119-t1x9gknd 2689 57 affect affect VB cord-010119-t1x9gknd 2689 58 RBC RBC NNP cord-010119-t1x9gknd 2689 59 function function NN cord-010119-t1x9gknd 2689 60 . . . cord-010119-t1x9gknd 2690 1 Microbial microbial JJ cord-010119-t1x9gknd 2690 2 Pathogen Pathogen NNP cord-010119-t1x9gknd 2690 3 Primary Primary NNP cord-010119-t1x9gknd 2690 4 Sequence Sequence NNP cord-010119-t1x9gknd 2690 5 Correlates correlate VBZ cord-010119-t1x9gknd 2690 6 with with IN cord-010119-t1x9gknd 2690 7 Blood blood NN cord-010119-t1x9gknd 2690 8 Group Group NNP cord-010119-t1x9gknd 2691 1 Antigen Antigen NNP cord-010119-t1x9gknd 2691 2 Immunogenicity Immunogenicity NNP cord-010119-t1x9gknd 2691 3 Ian Ian NNP cord-010119-t1x9gknd 2691 4 Baine Baine NNP cord-010119-t1x9gknd 2691 5 * * NFP cord-010119-t1x9gknd 2691 6 1 1 CD cord-010119-t1x9gknd 2691 7 , , , cord-010119-t1x9gknd 2691 8 Burak Burak NNP cord-010119-t1x9gknd 2691 9 Bahar Bahar NNP cord-010119-t1x9gknd 2691 10 1 1 CD cord-010119-t1x9gknd 2691 11 , , , cord-010119-t1x9gknd 2691 12 Jeanne Jeanne NNP cord-010119-t1x9gknd 2691 13 Hendrickson Hendrickson NNP cord-010119-t1x9gknd 2691 14 2 2 CD cord-010119-t1x9gknd 2691 15 , , , cord-010119-t1x9gknd 2691 16 Krystalyn Krystalyn NNP cord-010119-t1x9gknd 2691 17 E E NNP cord-010119-t1x9gknd 2691 18 Hudson Hudson NNP cord-010119-t1x9gknd 2691 19 3 3 CD cord-010119-t1x9gknd 2691 20 and and CC cord-010119-t1x9gknd 2691 21 Christopher Christopher NNP cord-010119-t1x9gknd 2691 22 A A NNP cord-010119-t1x9gknd 2691 23 Tormey Tormey NNP cord-010119-t1x9gknd 2691 24 1 1 CD cord-010119-t1x9gknd 2691 25 . . . cord-010119-t1x9gknd 2692 1 1 1 CD cord-010119-t1x9gknd 2692 2 Yale Yale NNP cord-010119-t1x9gknd 2692 3 - - HYPH cord-010119-t1x9gknd 2692 4 New New NNP cord-010119-t1x9gknd 2692 5 Haven Haven NNP cord-010119-t1x9gknd 2692 6 Hospital Hospital NNP cord-010119-t1x9gknd 2692 7 , , , cord-010119-t1x9gknd 2692 8 2 2 CD cord-010119-t1x9gknd 2692 9 Yale Yale NNP cord-010119-t1x9gknd 2692 10 University University NNP cord-010119-t1x9gknd 2692 11 , , , cord-010119-t1x9gknd 2692 12 3 3 CD cord-010119-t1x9gknd 2692 13 Background Background NNP cord-010119-t1x9gknd 2692 14 / / SYM cord-010119-t1x9gknd 2692 15 Case Case NNP cord-010119-t1x9gknd 2692 16 Studies Studies NNPS cord-010119-t1x9gknd 2692 17 : : : cord-010119-t1x9gknd 2693 1 It -PRON- PRP cord-010119-t1x9gknd 2693 2 is be VBZ cord-010119-t1x9gknd 2693 3 known know VBN cord-010119-t1x9gknd 2693 4 that that IN cord-010119-t1x9gknd 2693 5 specific specific JJ cord-010119-t1x9gknd 2693 6 groups group NNS cord-010119-t1x9gknd 2693 7 of of IN cord-010119-t1x9gknd 2693 8 patients patient NNS cord-010119-t1x9gknd 2693 9 immunologically immunologically RB cord-010119-t1x9gknd 2693 10 respond respond VBP cord-010119-t1x9gknd 2693 11 more more RBR cord-010119-t1x9gknd 2693 12 readily readily RB cord-010119-t1x9gknd 2693 13 than than IN cord-010119-t1x9gknd 2693 14 others other NNS cord-010119-t1x9gknd 2693 15 to to IN cord-010119-t1x9gknd 2693 16 RBC RBC NNP cord-010119-t1x9gknd 2693 17 antigens antigen NNS cord-010119-t1x9gknd 2693 18 . . . cord-010119-t1x9gknd 2694 1 While while IN cord-010119-t1x9gknd 2694 2 RBC RBC NNP cord-010119-t1x9gknd 2694 3 antigenic antigenic JJ cord-010119-t1x9gknd 2694 4 differences difference NNS cord-010119-t1x9gknd 2694 5 between between IN cord-010119-t1x9gknd 2694 6 donors donor NNS cord-010119-t1x9gknd 2694 7 and and CC cord-010119-t1x9gknd 2694 8 recipients recipient NNS cord-010119-t1x9gknd 2694 9 are be VBP cord-010119-t1x9gknd 2694 10 required require VBN cord-010119-t1x9gknd 2694 11 for for IN cord-010119-t1x9gknd 2694 12 humoral humoral JJ cord-010119-t1x9gknd 2694 13 immune immune JJ cord-010119-t1x9gknd 2694 14 responsiveness responsiveness NN cord-010119-t1x9gknd 2694 15 , , , cord-010119-t1x9gknd 2694 16 other other JJ cord-010119-t1x9gknd 2694 17 variables variable NNS cord-010119-t1x9gknd 2694 18 are be VBP cord-010119-t1x9gknd 2694 19 also also RB cord-010119-t1x9gknd 2694 20 involved involve VBN cord-010119-t1x9gknd 2694 21 . . . cord-010119-t1x9gknd 2695 1 Studies study NNS cord-010119-t1x9gknd 2695 2 have have VBP cord-010119-t1x9gknd 2695 3 shown show VBN cord-010119-t1x9gknd 2695 4 that that IN cord-010119-t1x9gknd 2695 5 there there EX cord-010119-t1x9gknd 2695 6 is be VBZ cord-010119-t1x9gknd 2695 7 significant significant JJ cord-010119-t1x9gknd 2695 8 primary primary JJ cord-010119-t1x9gknd 2695 9 sequence sequence NN cord-010119-t1x9gknd 2695 10 identity identity NN cord-010119-t1x9gknd 2695 11 between between IN cord-010119-t1x9gknd 2695 12 common common JJ cord-010119-t1x9gknd 2695 13 RBC RBC NNP cord-010119-t1x9gknd 2695 14 antigens antigen NNS cord-010119-t1x9gknd 2695 15 and and CC cord-010119-t1x9gknd 2695 16 microbes microbe NNS cord-010119-t1x9gknd 2695 17 , , , cord-010119-t1x9gknd 2695 18 and and CC cord-010119-t1x9gknd 2695 19 that that IN cord-010119-t1x9gknd 2695 20 cross cross NN cord-010119-t1x9gknd 2695 21 - - NN cord-010119-t1x9gknd 2695 22 reactivity reactivity NN cord-010119-t1x9gknd 2695 23 is be VBZ cord-010119-t1x9gknd 2695 24 possible possible JJ cord-010119-t1x9gknd 2695 25 between between IN cord-010119-t1x9gknd 2695 26 antigens antigen NNS cord-010119-t1x9gknd 2695 27 in in IN cord-010119-t1x9gknd 2695 28 experimental experimental JJ cord-010119-t1x9gknd 2695 29 models model NNS cord-010119-t1x9gknd 2695 30 . . . cord-010119-t1x9gknd 2696 1 We -PRON- PRP cord-010119-t1x9gknd 2696 2 hypothesize hypothesize VBP cord-010119-t1x9gknd 2696 3 that that IN cord-010119-t1x9gknd 2696 4 responder responder NN cord-010119-t1x9gknd 2696 5 populations population NNS cord-010119-t1x9gknd 2696 6 may may MD cord-010119-t1x9gknd 2696 7 be be VB cord-010119-t1x9gknd 2696 8 immunologically immunologically RB cord-010119-t1x9gknd 2696 9 primed prime VBN cord-010119-t1x9gknd 2696 10 to to TO cord-010119-t1x9gknd 2696 11 form form VB cord-010119-t1x9gknd 2696 12 RBC RBC NNP cord-010119-t1x9gknd 2696 13 alloantibodies alloantibody NNS cord-010119-t1x9gknd 2696 14 via via IN cord-010119-t1x9gknd 2696 15 environmental environmental JJ cord-010119-t1x9gknd 2696 16 exposure exposure NN cord-010119-t1x9gknd 2696 17 to to IN cord-010119-t1x9gknd 2696 18 cross cross JJ cord-010119-t1x9gknd 2696 19 - - JJ cord-010119-t1x9gknd 2696 20 reactive reactive JJ cord-010119-t1x9gknd 2696 21 microbial microbial JJ cord-010119-t1x9gknd 2696 22 antigens antigen NNS cord-010119-t1x9gknd 2696 23 , , , cord-010119-t1x9gknd 2696 24 and and CC cord-010119-t1x9gknd 2696 25 that that IN cord-010119-t1x9gknd 2696 26 such such PDT cord-010119-t1x9gknd 2696 27 a a DT cord-010119-t1x9gknd 2696 28 correlation correlation NN cord-010119-t1x9gknd 2696 29 may may MD cord-010119-t1x9gknd 2696 30 be be VB cord-010119-t1x9gknd 2696 31 linked link VBN cord-010119-t1x9gknd 2696 32 to to IN cord-010119-t1x9gknd 2696 33 observed observed JJ cord-010119-t1x9gknd 2696 34 blood blood NN cord-010119-t1x9gknd 2696 35 group group NN cord-010119-t1x9gknd 2696 36 antigen antigen NN cord-010119-t1x9gknd 2696 37 immunogenicity immunogenicity NN cord-010119-t1x9gknd 2696 38 . . . cord-010119-t1x9gknd 2697 1 Study Study NNP cord-010119-t1x9gknd 2697 2 Design Design NNP cord-010119-t1x9gknd 2697 3 / / SYM cord-010119-t1x9gknd 2697 4 Method method NN cord-010119-t1x9gknd 2697 5 : : : cord-010119-t1x9gknd 2697 6 We -PRON- PRP cord-010119-t1x9gknd 2697 7 performed perform VBD cord-010119-t1x9gknd 2697 8 peptide peptide NN cord-010119-t1x9gknd 2697 9 homology homology NN cord-010119-t1x9gknd 2697 10 searches search NNS cord-010119-t1x9gknd 2697 11 of of IN cord-010119-t1x9gknd 2697 12 the the DT cord-010119-t1x9gknd 2697 13 most most RBS cord-010119-t1x9gknd 2697 14 immunogenic immunogenic JJ cord-010119-t1x9gknd 2697 15 RBC RBC NNP cord-010119-t1x9gknd 2697 16 antigens antigen NNS cord-010119-t1x9gknd 2697 17 , , , cord-010119-t1x9gknd 2697 18 based base VBN cord-010119-t1x9gknd 2697 19 on on IN cord-010119-t1x9gknd 2697 20 previously previously RB cord-010119-t1x9gknd 2697 21 published publish VBN cord-010119-t1x9gknd 2697 22 antigenicity antigenicity NN cord-010119-t1x9gknd 2697 23 findings finding NNS cord-010119-t1x9gknd 2697 24 . . . cord-010119-t1x9gknd 2698 1 Thirteen thirteen CD cord-010119-t1x9gknd 2699 1 amino amino NN cord-010119-t1x9gknd 2699 2 acid acid NN cord-010119-t1x9gknd 2699 3 peptides peptide NNS cord-010119-t1x9gknd 2699 4 containing contain VBG cord-010119-t1x9gknd 2699 5 the the DT cord-010119-t1x9gknd 2699 6 polymorphic polymorphic JJ cord-010119-t1x9gknd 2699 7 residues residue NNS cord-010119-t1x9gknd 2699 8 of of IN cord-010119-t1x9gknd 2699 9 K k NN cord-010119-t1x9gknd 2699 10 , , , cord-010119-t1x9gknd 2700 1 Jk Jk NNP cord-010119-t1x9gknd 2700 2 a a DT cord-010119-t1x9gknd 2700 3 , , , cord-010119-t1x9gknd 2700 4 Lu Lu NNP cord-010119-t1x9gknd 2700 5 a a NNP cord-010119-t1x9gknd 2700 6 , , , cord-010119-t1x9gknd 2700 7 E E NNP cord-010119-t1x9gknd 2700 8 , , , cord-010119-t1x9gknd 2700 9 c c NNP cord-010119-t1x9gknd 2700 10 , , , cord-010119-t1x9gknd 2700 11 M M NNP cord-010119-t1x9gknd 2700 12 , , , cord-010119-t1x9gknd 2700 13 C C NNP cord-010119-t1x9gknd 2700 14 , , , cord-010119-t1x9gknd 2700 15 Fy Fy NNP cord-010119-t1x9gknd 2700 16 a a NNP cord-010119-t1x9gknd 2700 17 , , , cord-010119-t1x9gknd 2700 18 and and CC cord-010119-t1x9gknd 2700 19 S s NN cord-010119-t1x9gknd 2700 20 antigens antigen NNS cord-010119-t1x9gknd 2700 21 were be VBD cord-010119-t1x9gknd 2700 22 queried query VBN cord-010119-t1x9gknd 2700 23 for for IN cord-010119-t1x9gknd 2700 24 identity identity NN cord-010119-t1x9gknd 2700 25 with with IN cord-010119-t1x9gknd 2700 26 microbial microbial JJ cord-010119-t1x9gknd 2700 27 peptides peptide NNS cord-010119-t1x9gknd 2700 28 using use VBG cord-010119-t1x9gknd 2700 29 the the DT cord-010119-t1x9gknd 2700 30 BLAST blast NN cord-010119-t1x9gknd 2700 31 database database NN cord-010119-t1x9gknd 2700 32 ( ( -LRB- cord-010119-t1x9gknd 2700 33 blastp blastp NNP cord-010119-t1x9gknd 2700 34 , , , cord-010119-t1x9gknd 2700 35 PAM30 PAM30 NNP cord-010119-t1x9gknd 2700 36 ABSTRACT abstract JJ cord-010119-t1x9gknd 2700 37 algorithm algorithm NN cord-010119-t1x9gknd 2700 38 , , , cord-010119-t1x9gknd 2700 39 E E NNP cord-010119-t1x9gknd 2700 40 value51x10 value51x10 NNP cord-010119-t1x9gknd 2700 41 -6 -6 NNP cord-010119-t1x9gknd 2700 42 , , , cord-010119-t1x9gknd 2701 1 Word word NN cord-010119-t1x9gknd 2702 1 Size5 Size5 NNP cord-010119-t1x9gknd 2702 2 6 6 CD cord-010119-t1x9gknd 2702 3 , , , cord-010119-t1x9gknd 2702 4 Gap Gap NNP cord-010119-t1x9gknd 2702 5 Costs cost NNS cord-010119-t1x9gknd 2702 6 : : : cord-010119-t1x9gknd 2703 1 Existence59 Existence59 NNP cord-010119-t1x9gknd 2704 1 Exten exten NN cord-010119-t1x9gknd 2704 2 - - HYPH cord-010119-t1x9gknd 2704 3 sion51 sion51 ADD cord-010119-t1x9gknd 2704 4 ) ) -RRB- cord-010119-t1x9gknd 2704 5 . . . cord-010119-t1x9gknd 2705 1 Search search NN cord-010119-t1x9gknd 2705 2 results result NNS cord-010119-t1x9gknd 2705 3 were be VBD cord-010119-t1x9gknd 2705 4 restricted restrict VBN cord-010119-t1x9gknd 2705 5 to to IN cord-010119-t1x9gknd 2705 6 bacteria bacteria NNS cord-010119-t1x9gknd 2705 7 and and CC cord-010119-t1x9gknd 2705 8 fungi fungus NNS cord-010119-t1x9gknd 2705 9 , , , cord-010119-t1x9gknd 2705 10 with with IN cord-010119-t1x9gknd 2705 11 a a DT cord-010119-t1x9gknd 2705 12 selective selective JJ cord-010119-t1x9gknd 2705 13 threshold threshold NN cord-010119-t1x9gknd 2705 14 of of IN cord-010119-t1x9gknd 2705 15 > > $ cord-010119-t1x9gknd 2705 16 80 80 CD cord-010119-t1x9gknd 2705 17 % % NN cord-010119-t1x9gknd 2705 18 identity identity NN cord-010119-t1x9gknd 2705 19 set set VBN cord-010119-t1x9gknd 2705 20 for for IN cord-010119-t1x9gknd 2705 21 inclusion inclusion NN cord-010119-t1x9gknd 2705 22 criteria criterion NNS cord-010119-t1x9gknd 2705 23 . . . cord-010119-t1x9gknd 2706 1 To to TO cord-010119-t1x9gknd 2706 2 corroborate corroborate VB cord-010119-t1x9gknd 2706 3 with with IN cord-010119-t1x9gknd 2706 4 observed observed JJ cord-010119-t1x9gknd 2706 5 patient patient JJ cord-010119-t1x9gknd 2706 6 data datum NNS cord-010119-t1x9gknd 2706 7 , , , cord-010119-t1x9gknd 2706 8 we -PRON- PRP cord-010119-t1x9gknd 2706 9 also also RB cord-010119-t1x9gknd 2706 10 examined examine VBD cord-010119-t1x9gknd 2706 11 preceding precede VBG cord-010119-t1x9gknd 2706 12 cultures culture NNS cord-010119-t1x9gknd 2706 13 from from IN cord-010119-t1x9gknd 2706 14 162 162 CD cord-010119-t1x9gknd 2706 15 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 2706 16 patients patient NNS cord-010119-t1x9gknd 2706 17 to to TO cord-010119-t1x9gknd 2706 18 explore explore VB cord-010119-t1x9gknd 2706 19 agreement agreement NN cord-010119-t1x9gknd 2706 20 between between IN cord-010119-t1x9gknd 2706 21 specific specific JJ cord-010119-t1x9gknd 2706 22 pathogens pathogen NNS cord-010119-t1x9gknd 2706 23 and and CC cord-010119-t1x9gknd 2706 24 RBC RBC NNP cord-010119-t1x9gknd 2706 25 alloantibodies alloantibody NNS cord-010119-t1x9gknd 2706 26 . . . cord-010119-t1x9gknd 2707 1 Results/ Results/ . cord-010119-t1x9gknd 2708 1 Finding finding NN cord-010119-t1x9gknd 2708 2 : : : cord-010119-t1x9gknd 2709 1 Significant significant JJ cord-010119-t1x9gknd 2709 2 peptide peptide JJ cord-010119-t1x9gknd 2709 3 identity identity NN cord-010119-t1x9gknd 2709 4 was be VBD cord-010119-t1x9gknd 2709 5 found find VBN cord-010119-t1x9gknd 2709 6 between between IN cord-010119-t1x9gknd 2709 7 RBC RBC NNP cord-010119-t1x9gknd 2709 8 antigens antigen NNS cord-010119-t1x9gknd 2709 9 and and CC cord-010119-t1x9gknd 2709 10 pathogenic pathogenic JJ cord-010119-t1x9gknd 2709 11 organisms organism NNS cord-010119-t1x9gknd 2709 12 including include VBG cord-010119-t1x9gknd 2709 13 B. B. NNP cord-010119-t1x9gknd 2709 14 fragilis fragili NNS cord-010119-t1x9gknd 2709 15 , , , cord-010119-t1x9gknd 2709 16 P. p. NN cord-010119-t1x9gknd 2709 17 aeruginosa aeruginosa NN cord-010119-t1x9gknd 2709 18 , , , cord-010119-t1x9gknd 2709 19 Candida Candida NNP cord-010119-t1x9gknd 2709 20 spp spp NNS cord-010119-t1x9gknd 2709 21 . . . cord-010119-t1x9gknd 2710 1 among among IN cord-010119-t1x9gknd 2710 2 others other NNS cord-010119-t1x9gknd 2710 3 . . . cord-010119-t1x9gknd 2711 1 Linear linear JJ cord-010119-t1x9gknd 2711 2 regression regression NN cord-010119-t1x9gknd 2711 3 analysis analysis NN cord-010119-t1x9gknd 2711 4 of of IN cord-010119-t1x9gknd 2711 5 the the DT cord-010119-t1x9gknd 2711 6 number number NN cord-010119-t1x9gknd 2711 7 of of IN cord-010119-t1x9gknd 2711 8 genuses genus NNS cord-010119-t1x9gknd 2711 9 in in IN cord-010119-t1x9gknd 2711 10 microbial microbial JJ cord-010119-t1x9gknd 2711 11 kingdoms kingdom NNS cord-010119-t1x9gknd 2711 12 meeting meeting NN cord-010119-t1x9gknd 2711 13 inclusion inclusion NN cord-010119-t1x9gknd 2711 14 criteria criterion NNS cord-010119-t1x9gknd 2711 15 showed show VBD cord-010119-t1x9gknd 2711 16 a a DT cord-010119-t1x9gknd 2711 17 statistically statistically RB cord-010119-t1x9gknd 2711 18 significant significant JJ cord-010119-t1x9gknd 2711 19 inverse inverse JJ cord-010119-t1x9gknd 2711 20 trend trend NN cord-010119-t1x9gknd 2711 21 in in IN cord-010119-t1x9gknd 2711 22 predicting predict VBG cord-010119-t1x9gknd 2711 23 the the DT cord-010119-t1x9gknd 2711 24 degree degree NN cord-010119-t1x9gknd 2711 25 of of IN cord-010119-t1x9gknd 2711 26 immunogenicity immunogenicity NN cord-010119-t1x9gknd 2711 27 when when WRB cord-010119-t1x9gknd 2711 28 Fy Fy NNP cord-010119-t1x9gknd 2711 29 a a DT cord-010119-t1x9gknd 2711 30 ( ( -LRB- cord-010119-t1x9gknd 2711 31 an an DT cord-010119-t1x9gknd 2711 32 outlier outlier NN cord-010119-t1x9gknd 2711 33 ) ) -RRB- cord-010119-t1x9gknd 2711 34 was be VBD cord-010119-t1x9gknd 2711 35 removed remove VBN cord-010119-t1x9gknd 2711 36 ( ( -LRB- cord-010119-t1x9gknd 2711 37 b5 b5 NNP cord-010119-t1x9gknd 2711 38 - - HYPH cord-010119-t1x9gknd 2711 39 0.0017 0.0017 CD cord-010119-t1x9gknd 2711 40 , , , cord-010119-t1x9gknd 2711 41 r r NNP cord-010119-t1x9gknd 2711 42 2 2 CD cord-010119-t1x9gknd 2711 43 50.624 50.624 CD cord-010119-t1x9gknd 2711 44 & & CC cord-010119-t1x9gknd 2711 45 p50.0197 p50.0197 NNP cord-010119-t1x9gknd 2711 46 ) ) -RRB- cord-010119-t1x9gknd 2711 47 ; ; : cord-010119-t1x9gknd 2711 48 that that RB cord-010119-t1x9gknd 2711 49 is is RB cord-010119-t1x9gknd 2711 50 , , , cord-010119-t1x9gknd 2711 51 lower low JJR cord-010119-t1x9gknd 2711 52 immunogenicity immunogenicity NN cord-010119-t1x9gknd 2711 53 antigens antigen NNS cord-010119-t1x9gknd 2711 54 were be VBD cord-010119-t1x9gknd 2711 55 associated associate VBN cord-010119-t1x9gknd 2711 56 with with IN cord-010119-t1x9gknd 2711 57 larger large JJR cord-010119-t1x9gknd 2711 58 number number NN cord-010119-t1x9gknd 2711 59 of of IN cord-010119-t1x9gknd 2711 60 kingdoms kingdom NNS cord-010119-t1x9gknd 2711 61 . . . cord-010119-t1x9gknd 2712 1 k k NNP cord-010119-t1x9gknd 2712 2 - - HYPH cord-010119-t1x9gknd 2712 3 medoids medoids NNP cord-010119-t1x9gknd 2712 4 cluster cluster NN cord-010119-t1x9gknd 2712 5 analysis analysis NN cord-010119-t1x9gknd 2712 6 comparing compare VBG cord-010119-t1x9gknd 2712 7 immunogenicity immunogenicity NN cord-010119-t1x9gknd 2712 8 and and CC cord-010119-t1x9gknd 2712 9 kingdoms kingdom NNS cord-010119-t1x9gknd 2712 10 showed show VBD cord-010119-t1x9gknd 2712 11 that that IN cord-010119-t1x9gknd 2712 12 antigens antigen NNS cord-010119-t1x9gknd 2712 13 clustered cluster VBN cord-010119-t1x9gknd 2712 14 to to IN cord-010119-t1x9gknd 2712 15 low low JJ cord-010119-t1x9gknd 2712 16 ( ( -LRB- cord-010119-t1x9gknd 2712 17 C C NNP cord-010119-t1x9gknd 2712 18 ) ) -RRB- cord-010119-t1x9gknd 2712 19 , , , cord-010119-t1x9gknd 2712 20 moderate moderate JJ cord-010119-t1x9gknd 2712 21 ( ( -LRB- cord-010119-t1x9gknd 2712 22 E e NN cord-010119-t1x9gknd 2712 23 , , , cord-010119-t1x9gknd 2712 24 c c NN cord-010119-t1x9gknd 2712 25 , , , cord-010119-t1x9gknd 2712 26 S S NNP cord-010119-t1x9gknd 2712 27 , , , cord-010119-t1x9gknd 2712 28 M M NNP cord-010119-t1x9gknd 2712 29 ) ) -RRB- cord-010119-t1x9gknd 2712 30 and and CC cord-010119-t1x9gknd 2712 31 high high JJ cord-010119-t1x9gknd 2712 32 ( ( -LRB- cord-010119-t1x9gknd 2712 33 K k XX cord-010119-t1x9gknd 2712 34 , , , cord-010119-t1x9gknd 2712 35 Jk Jk NNP cord-010119-t1x9gknd 2712 36 a a NNP cord-010119-t1x9gknd 2712 37 , , , cord-010119-t1x9gknd 2712 38 Lu Lu NNP cord-010119-t1x9gknd 2712 39 a a NNP cord-010119-t1x9gknd 2712 40 , , , cord-010119-t1x9gknd 2712 41 Fy Fy NNP cord-010119-t1x9gknd 2712 42 a a DT cord-010119-t1x9gknd 2712 43 ) ) -RRB- cord-010119-t1x9gknd 2712 44 immunogenicity immunogenicity NN cord-010119-t1x9gknd 2712 45 groups group NNS cord-010119-t1x9gknd 2712 46 , , , cord-010119-t1x9gknd 2712 47 suggesting suggest VBG cord-010119-t1x9gknd 2712 48 that that IN cord-010119-t1x9gknd 2712 49 an an DT cord-010119-t1x9gknd 2712 50 antibody antibody NN cord-010119-t1x9gknd 2712 51 response response NN cord-010119-t1x9gknd 2712 52 is be VBZ cord-010119-t1x9gknd 2712 53 inversely inversely RB cord-010119-t1x9gknd 2712 54 associated associate VBN cord-010119-t1x9gknd 2712 55 with with IN cord-010119-t1x9gknd 2712 56 environmental environmental JJ cord-010119-t1x9gknd 2712 57 antigenic antigenic JJ cord-010119-t1x9gknd 2712 58 prevalence prevalence NN cord-010119-t1x9gknd 2712 59 . . . cord-010119-t1x9gknd 2713 1 Of of IN cord-010119-t1x9gknd 2713 2 162 162 CD cord-010119-t1x9gknd 2713 3 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 2713 4 patients patient NNS cord-010119-t1x9gknd 2713 5 reviewed review VBN cord-010119-t1x9gknd 2713 6 , , , cord-010119-t1x9gknd 2713 7 105 105 CD cord-010119-t1x9gknd 2713 8 were be VBD cord-010119-t1x9gknd 2713 9 culture culture NN cord-010119-t1x9gknd 2713 10 - - HYPH cord-010119-t1x9gknd 2713 11 positive positive JJ cord-010119-t1x9gknd 2713 12 . . . cord-010119-t1x9gknd 2714 1 Of of IN cord-010119-t1x9gknd 2714 2 these these DT cord-010119-t1x9gknd 2714 3 , , , cord-010119-t1x9gknd 2714 4 76 76 CD cord-010119-t1x9gknd 2714 5 % % NN cord-010119-t1x9gknd 2714 6 of of IN cord-010119-t1x9gknd 2714 7 the the DT cord-010119-t1x9gknd 2714 8 anti anti JJ cord-010119-t1x9gknd 2714 9 - - NNP cord-010119-t1x9gknd 2714 10 C C NNP cord-010119-t1x9gknd 2714 11 / / SYM cord-010119-t1x9gknd 2714 12 c c NN cord-010119-t1x9gknd 2714 13 group group NN cord-010119-t1x9gknd 2714 14 ( ( -LRB- cord-010119-t1x9gknd 2714 15 13 13 CD cord-010119-t1x9gknd 2714 16 of of IN cord-010119-t1x9gknd 2714 17 17 17 CD cord-010119-t1x9gknd 2714 18 patients patient NNS cord-010119-t1x9gknd 2714 19 ) ) -RRB- cord-010119-t1x9gknd 2714 20 and and CC cord-010119-t1x9gknd 2714 21 16 16 CD cord-010119-t1x9gknd 2714 22 % % NN cord-010119-t1x9gknd 2714 23 of of IN cord-010119-t1x9gknd 2714 24 the the DT cord-010119-t1x9gknd 2714 25 anti anti JJ cord-010119-t1x9gknd 2714 26 - - JJ cord-010119-t1x9gknd 2714 27 K k JJ cord-010119-t1x9gknd 2714 28 group group NN cord-010119-t1x9gknd 2714 29 ( ( -LRB- cord-010119-t1x9gknd 2714 30 7 7 CD cord-010119-t1x9gknd 2714 31 of of IN cord-010119-t1x9gknd 2714 32 43 43 CD cord-010119-t1x9gknd 2714 33 patients patient NNS cord-010119-t1x9gknd 2714 34 ) ) -RRB- cord-010119-t1x9gknd 2714 35 had have VBD cord-010119-t1x9gknd 2714 36 microbe microbe NN cord-010119-t1x9gknd 2714 37 - - HYPH cord-010119-t1x9gknd 2714 38 antibody antibody NN cord-010119-t1x9gknd 2714 39 agreement agreement NN cord-010119-t1x9gknd 2714 40 . . . cord-010119-t1x9gknd 2715 1 Remaining remain VBG cord-010119-t1x9gknd 2715 2 microbe microbe NN cord-010119-t1x9gknd 2715 3 - - HYPH cord-010119-t1x9gknd 2715 4 RBC RBC NNP cord-010119-t1x9gknd 2715 5 antibody antibody NN cord-010119-t1x9gknd 2715 6 agreements agreement NNS cord-010119-t1x9gknd 2715 7 ranged range VBD cord-010119-t1x9gknd 2715 8 from from IN cord-010119-t1x9gknd 2715 9 0 0 CD cord-010119-t1x9gknd 2715 10 -11.1 -11.1 CD cord-010119-t1x9gknd 2715 11 % % NN cord-010119-t1x9gknd 2715 12 . . . cord-010119-t1x9gknd 2716 1 Overall overall RB cord-010119-t1x9gknd 2716 2 , , , cord-010119-t1x9gknd 2716 3 21.9 21.9 CD cord-010119-t1x9gknd 2716 4 % % NN cord-010119-t1x9gknd 2716 5 ( ( -LRB- cord-010119-t1x9gknd 2716 6 23 23 CD cord-010119-t1x9gknd 2716 7 of of IN cord-010119-t1x9gknd 2716 8 105 105 CD cord-010119-t1x9gknd 2716 9 patients patient NNS cord-010119-t1x9gknd 2716 10 ) ) -RRB- cord-010119-t1x9gknd 2716 11 demonstrated demonstrate VBD cord-010119-t1x9gknd 2716 12 agreement agreement NN cord-010119-t1x9gknd 2716 13 . . . cord-010119-t1x9gknd 2717 1 Interestingly interestingly RB cord-010119-t1x9gknd 2717 2 , , , cord-010119-t1x9gknd 2717 3 we -PRON- PRP cord-010119-t1x9gknd 2717 4 observed observe VBD cord-010119-t1x9gknd 2717 5 a a DT cord-010119-t1x9gknd 2717 6 particularly particularly RB cord-010119-t1x9gknd 2717 7 strong strong JJ cord-010119-t1x9gknd 2717 8 agreement agreement NN cord-010119-t1x9gknd 2717 9 between between IN cord-010119-t1x9gknd 2717 10 infection infection NN cord-010119-t1x9gknd 2717 11 with with IN cord-010119-t1x9gknd 2717 12 Klebsiella Klebsiella NNP cord-010119-t1x9gknd 2717 13 species specie NNS cord-010119-t1x9gknd 2717 14 and and CC cord-010119-t1x9gknd 2717 15 anti anti JJ cord-010119-t1x9gknd 2717 16 - - JJ cord-010119-t1x9gknd 2717 17 K k JJ cord-010119-t1x9gknd 2717 18 , , , cord-010119-t1x9gknd 2717 19 despite despite IN cord-010119-t1x9gknd 2717 20 the the DT cord-010119-t1x9gknd 2717 21 lack lack NN cord-010119-t1x9gknd 2717 22 of of IN cord-010119-t1x9gknd 2717 23 > > $ cord-010119-t1x9gknd 2717 24 80 80 CD cord-010119-t1x9gknd 2717 25 % % NN cord-010119-t1x9gknd 2717 26 sequence sequence NN cord-010119-t1x9gknd 2717 27 identity identity NN cord-010119-t1x9gknd 2717 28 . . . cord-010119-t1x9gknd 2718 1 While while IN cord-010119-t1x9gknd 2718 2 27.6 27.6 CD cord-010119-t1x9gknd 2718 3 % % NN cord-010119-t1x9gknd 2718 4 ( ( -LRB- cord-010119-t1x9gknd 2718 5 29 29 CD cord-010119-t1x9gknd 2718 6 of of IN cord-010119-t1x9gknd 2718 7 105 105 CD cord-010119-t1x9gknd 2718 8 ) ) -RRB- cord-010119-t1x9gknd 2718 9 patients patient NNS cord-010119-t1x9gknd 2718 10 reviewed review VBN cord-010119-t1x9gknd 2718 11 had have VBD cord-010119-t1x9gknd 2718 12 positive positive JJ cord-010119-t1x9gknd 2718 13 cultures culture NNS cord-010119-t1x9gknd 2718 14 for for IN cord-010119-t1x9gknd 2718 15 Klebsiella Klebsiella NNP cord-010119-t1x9gknd 2718 16 species specie NNS cord-010119-t1x9gknd 2718 17 , , , cord-010119-t1x9gknd 2718 18 62.1 62.1 CD cord-010119-t1x9gknd 2718 19 % % NN cord-010119-t1x9gknd 2718 20 of of IN cord-010119-t1x9gknd 2718 21 these these DT cord-010119-t1x9gknd 2718 22 ( ( -LRB- cord-010119-t1x9gknd 2718 23 18 18 CD cord-010119-t1x9gknd 2718 24 of of IN cord-010119-t1x9gknd 2718 25 29 29 CD cord-010119-t1x9gknd 2718 26 patients patient NNS cord-010119-t1x9gknd 2718 27 ) ) -RRB- cord-010119-t1x9gknd 2718 28 demonstrated demonstrate VBD cord-010119-t1x9gknd 2718 29 an an DT cord-010119-t1x9gknd 2718 30 anti anti JJ cord-010119-t1x9gknd 2718 31 - - JJ cord-010119-t1x9gknd 2718 32 K. k. JJ cord-010119-t1x9gknd 2718 33 Conclusion conclusion NN cord-010119-t1x9gknd 2718 34 : : : cord-010119-t1x9gknd 2719 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2719 2 study study NN cord-010119-t1x9gknd 2719 3 highlights highlight VBZ cord-010119-t1x9gknd 2719 4 the the DT cord-010119-t1x9gknd 2719 5 potential potential JJ cord-010119-t1x9gknd 2719 6 connection connection NN cord-010119-t1x9gknd 2719 7 between between IN cord-010119-t1x9gknd 2719 8 microbial microbial JJ cord-010119-t1x9gknd 2719 9 infection infection NN cord-010119-t1x9gknd 2719 10 and and CC cord-010119-t1x9gknd 2719 11 RBC RBC NNP cord-010119-t1x9gknd 2719 12 alloimmunization alloimmunization NN cord-010119-t1x9gknd 2719 13 , , , cord-010119-t1x9gknd 2719 14 based base VBN cord-010119-t1x9gknd 2719 15 on on IN cord-010119-t1x9gknd 2719 16 shared share VBN cord-010119-t1x9gknd 2719 17 epitopes epitope NNS cord-010119-t1x9gknd 2719 18 . . . cord-010119-t1x9gknd 2720 1 We -PRON- PRP cord-010119-t1x9gknd 2720 2 speculate speculate VBP cord-010119-t1x9gknd 2720 3 that that IN cord-010119-t1x9gknd 2720 4 low low JJ cord-010119-t1x9gknd 2720 5 - - HYPH cord-010119-t1x9gknd 2720 6 level level NN cord-010119-t1x9gknd 2720 7 antigenic antigenic JJ cord-010119-t1x9gknd 2720 8 exposure exposure NN cord-010119-t1x9gknd 2720 9 to to IN cord-010119-t1x9gknd 2720 10 highly highly RB cord-010119-t1x9gknd 2720 11 prevalent prevalent JJ cord-010119-t1x9gknd 2720 12 microbial microbial JJ cord-010119-t1x9gknd 2720 13 antigens antigen NNS cord-010119-t1x9gknd 2720 14 such such JJ cord-010119-t1x9gknd 2720 15 as as IN cord-010119-t1x9gknd 2720 16 commensals commensal NNS cord-010119-t1x9gknd 2720 17 may may MD cord-010119-t1x9gknd 2720 18 promote promote VB cord-010119-t1x9gknd 2720 19 immunotolerance immunotolerance NNP cord-010119-t1x9gknd 2720 20 , , , cord-010119-t1x9gknd 2720 21 providing provide VBG cord-010119-t1x9gknd 2720 22 a a DT cord-010119-t1x9gknd 2720 23 model model NN cord-010119-t1x9gknd 2720 24 for for IN cord-010119-t1x9gknd 2720 25 the the DT cord-010119-t1x9gknd 2720 26 inverse inverse JJ cord-010119-t1x9gknd 2720 27 relationship relationship NN cord-010119-t1x9gknd 2720 28 between between IN cord-010119-t1x9gknd 2720 29 RBC RBC NNP cord-010119-t1x9gknd 2720 30 antigen antigen NN cord-010119-t1x9gknd 2720 31 immunogenicity immunogenicity NN cord-010119-t1x9gknd 2720 32 and and CC cord-010119-t1x9gknd 2720 33 prevalence prevalence NN cord-010119-t1x9gknd 2720 34 of of IN cord-010119-t1x9gknd 2720 35 microorganisms microorganism NNS cord-010119-t1x9gknd 2720 36 . . . cord-010119-t1x9gknd 2721 1 Longitudinal longitudinal JJ cord-010119-t1x9gknd 2721 2 studies study NNS cord-010119-t1x9gknd 2721 3 of of IN cord-010119-t1x9gknd 2721 4 microbial microbial JJ cord-010119-t1x9gknd 2721 5 carriage carriage NN cord-010119-t1x9gknd 2721 6 ( ( -LRB- cord-010119-t1x9gknd 2721 7 or or CC cord-010119-t1x9gknd 2721 8 acute acute JJ cord-010119-t1x9gknd 2721 9 microbial microbial JJ cord-010119-t1x9gknd 2721 10 infection infection NN cord-010119-t1x9gknd 2721 11 ) ) -RRB- cord-010119-t1x9gknd 2721 12 and and CC cord-010119-t1x9gknd 2721 13 RBC RBC NNP cord-010119-t1x9gknd 2721 14 alloimmune alloimmune NNP cord-010119-t1x9gknd 2721 15 responses response NNS cord-010119-t1x9gknd 2721 16 in in IN cord-010119-t1x9gknd 2721 17 larger large JJR cord-010119-t1x9gknd 2721 18 patient patient JJ cord-010119-t1x9gknd 2721 19 cohorts cohort NNS cord-010119-t1x9gknd 2721 20 may may MD cord-010119-t1x9gknd 2721 21 be be VB cord-010119-t1x9gknd 2721 22 informative informative JJ cord-010119-t1x9gknd 2721 23 . . . cord-010119-t1x9gknd 2722 1 Background Background NNP cord-010119-t1x9gknd 2722 2 / / SYM cord-010119-t1x9gknd 2722 3 Case Case NNP cord-010119-t1x9gknd 2722 4 Studies Studies NNPS cord-010119-t1x9gknd 2722 5 : : : cord-010119-t1x9gknd 2722 6 Thromboelastogram Thromboelastogram NNP cord-010119-t1x9gknd 2722 7 ( ( -LRB- cord-010119-t1x9gknd 2722 8 TEG TEG NNP cord-010119-t1x9gknd 2722 9 ) ) -RRB- cord-010119-t1x9gknd 2722 10 has have VBZ cord-010119-t1x9gknd 2722 11 been be VBN cord-010119-t1x9gknd 2722 12 incorporated incorporate VBN cord-010119-t1x9gknd 2722 13 into into IN cord-010119-t1x9gknd 2722 14 many many JJ cord-010119-t1x9gknd 2722 15 hospital hospital NN cord-010119-t1x9gknd 2722 16 armories armory NNS cord-010119-t1x9gknd 2722 17 to to TO cord-010119-t1x9gknd 2722 18 manage manage VB cord-010119-t1x9gknd 2722 19 transfusions transfusion NNS cord-010119-t1x9gknd 2722 20 during during IN cord-010119-t1x9gknd 2722 21 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 2722 22 ( ( -LRB- cord-010119-t1x9gknd 2722 23 CV cv NN cord-010119-t1x9gknd 2722 24 ) ) -RRB- cord-010119-t1x9gknd 2722 25 surgeries surgery NNS cord-010119-t1x9gknd 2722 26 . . . cord-010119-t1x9gknd 2723 1 Some some DT cord-010119-t1x9gknd 2723 2 institutions institution NNS cord-010119-t1x9gknd 2723 3 use use VBP cord-010119-t1x9gknd 2723 4 well well RB cord-010119-t1x9gknd 2723 5 - - HYPH cord-010119-t1x9gknd 2723 6 defined define VBN cord-010119-t1x9gknd 2723 7 protocols protocol NNS cord-010119-t1x9gknd 2723 8 for for IN cord-010119-t1x9gknd 2723 9 TEG TEG NNP cord-010119-t1x9gknd 2723 10 utilization utilization NN cord-010119-t1x9gknd 2723 11 at at IN cord-010119-t1x9gknd 2723 12 different different JJ cord-010119-t1x9gknd 2723 13 stages stage NNS cord-010119-t1x9gknd 2723 14 of of IN cord-010119-t1x9gknd 2723 15 surgery surgery NN cord-010119-t1x9gknd 2723 16 ( ( -LRB- cord-010119-t1x9gknd 2723 17 baseline baseline NN cord-010119-t1x9gknd 2723 18 , , , cord-010119-t1x9gknd 2723 19 rewarming rewarming NN cord-010119-t1x9gknd 2723 20 , , , cord-010119-t1x9gknd 2723 21 postprotamine postprotamine NN cord-010119-t1x9gknd 2723 22 , , , cord-010119-t1x9gknd 2723 23 and and CC cord-010119-t1x9gknd 2723 24 post post JJ cord-010119-t1x9gknd 2723 25 - - JJ cord-010119-t1x9gknd 2723 26 operative operative JJ cord-010119-t1x9gknd 2723 27 ) ) -RRB- cord-010119-t1x9gknd 2723 28 . . . cord-010119-t1x9gknd 2724 1 On on IN cord-010119-t1x9gknd 2724 2 the the DT cord-010119-t1x9gknd 2724 3 other other JJ cord-010119-t1x9gknd 2724 4 hand hand NN cord-010119-t1x9gknd 2724 5 , , , cord-010119-t1x9gknd 2724 6 at at IN cord-010119-t1x9gknd 2724 7 some some DT cord-010119-t1x9gknd 2724 8 institutions institution NNS cord-010119-t1x9gknd 2724 9 TEG TEG NNP cord-010119-t1x9gknd 2724 10 utilization utilization NN cord-010119-t1x9gknd 2724 11 is be VBZ cord-010119-t1x9gknd 2724 12 driven drive VBN cord-010119-t1x9gknd 2724 13 mainly mainly RB cord-010119-t1x9gknd 2724 14 by by IN cord-010119-t1x9gknd 2724 15 clinical clinical JJ cord-010119-t1x9gknd 2724 16 judgment judgment NN cord-010119-t1x9gknd 2724 17 . . . cord-010119-t1x9gknd 2725 1 When when WRB cord-010119-t1x9gknd 2725 2 TEG TEG NNP cord-010119-t1x9gknd 2725 3 is be VBZ cord-010119-t1x9gknd 2725 4 ordered order VBN cord-010119-t1x9gknd 2725 5 based base VBN cord-010119-t1x9gknd 2725 6 on on IN cord-010119-t1x9gknd 2725 7 clinical clinical JJ cord-010119-t1x9gknd 2725 8 judgment judgment NN cord-010119-t1x9gknd 2725 9 ( ( -LRB- cord-010119-t1x9gknd 2725 10 clinical clinical JJ cord-010119-t1x9gknd 2725 11 bleeding bleeding NN cord-010119-t1x9gknd 2725 12 in in IN cord-010119-t1x9gknd 2725 13 most most JJS cord-010119-t1x9gknd 2725 14 cases case NNS cord-010119-t1x9gknd 2725 15 ) ) -RRB- cord-010119-t1x9gknd 2725 16 , , , cord-010119-t1x9gknd 2725 17 some some DT cord-010119-t1x9gknd 2725 18 patients patient NNS cord-010119-t1x9gknd 2725 19 receive receive VBP cord-010119-t1x9gknd 2725 20 blood blood NN cord-010119-t1x9gknd 2725 21 transfusions transfusion NNS cord-010119-t1x9gknd 2725 22 before before IN cord-010119-t1x9gknd 2725 23 TEG TEG NNP cord-010119-t1x9gknd 2725 24 is be VBZ cord-010119-t1x9gknd 2725 25 performed perform VBN cord-010119-t1x9gknd 2725 26 . . . cord-010119-t1x9gknd 2726 1 There there EX cord-010119-t1x9gknd 2726 2 is be VBZ cord-010119-t1x9gknd 2726 3 no no DT cord-010119-t1x9gknd 2726 4 published publish VBN cord-010119-t1x9gknd 2726 5 literature literature NN cord-010119-t1x9gknd 2726 6 on on IN cord-010119-t1x9gknd 2726 7 how how WRB cord-010119-t1x9gknd 2726 8 pre pre JJ cord-010119-t1x9gknd 2726 9 - - JJ cord-010119-t1x9gknd 2726 10 TEG TEG NNP cord-010119-t1x9gknd 2726 11 transfusions transfusion NNS cord-010119-t1x9gknd 2726 12 impact impact VBP cord-010119-t1x9gknd 2726 13 TEG TEG NNP cord-010119-t1x9gknd 2726 14 results result NNS cord-010119-t1x9gknd 2726 15 and and CC cord-010119-t1x9gknd 2726 16 guide guide VB cord-010119-t1x9gknd 2726 17 further further JJ cord-010119-t1x9gknd 2726 18 transfusion transfusion NN cord-010119-t1x9gknd 2726 19 requirements requirement NNS cord-010119-t1x9gknd 2726 20 during during IN cord-010119-t1x9gknd 2726 21 CV cv NN cord-010119-t1x9gknd 2726 22 surgeries surgery NNS cord-010119-t1x9gknd 2726 23 . . . cord-010119-t1x9gknd 2727 1 In in IN cord-010119-t1x9gknd 2727 2 this this DT cord-010119-t1x9gknd 2727 3 study study NN cord-010119-t1x9gknd 2727 4 , , , cord-010119-t1x9gknd 2727 5 we -PRON- PRP cord-010119-t1x9gknd 2727 6 have have VBP cord-010119-t1x9gknd 2727 7 tried try VBN cord-010119-t1x9gknd 2727 8 to to TO cord-010119-t1x9gknd 2727 9 address address VB cord-010119-t1x9gknd 2727 10 this this DT cord-010119-t1x9gknd 2727 11 issue issue NN cord-010119-t1x9gknd 2727 12 . . . cord-010119-t1x9gknd 2728 1 Study Study NNP cord-010119-t1x9gknd 2728 2 Design Design NNP cord-010119-t1x9gknd 2728 3 / / SYM cord-010119-t1x9gknd 2728 4 Method method NN cord-010119-t1x9gknd 2728 5 : : : cord-010119-t1x9gknd 2728 6 We -PRON- PRP cord-010119-t1x9gknd 2728 7 retrospectively retrospectively RB cord-010119-t1x9gknd 2728 8 reviewed review VBD cord-010119-t1x9gknd 2728 9 109 109 CD cord-010119-t1x9gknd 2728 10 TEGs teg NNS cord-010119-t1x9gknd 2728 11 performed perform VBN cord-010119-t1x9gknd 2728 12 on on IN cord-010119-t1x9gknd 2728 13 76 76 CD cord-010119-t1x9gknd 2728 14 patients patient NNS cord-010119-t1x9gknd 2728 15 undergoing undergo VBG cord-010119-t1x9gknd 2728 16 CV cv NN cord-010119-t1x9gknd 2728 17 surgeries surgery NNS cord-010119-t1x9gknd 2728 18 at at IN cord-010119-t1x9gknd 2728 19 our -PRON- PRP$ cord-010119-t1x9gknd 2728 20 institution institution NN cord-010119-t1x9gknd 2728 21 from from IN cord-010119-t1x9gknd 2728 22 Jan Jan NNP cord-010119-t1x9gknd 2728 23 1 1 CD cord-010119-t1x9gknd 2728 24 to to IN cord-010119-t1x9gknd 2728 25 Dec Dec NNP cord-010119-t1x9gknd 2728 26 31 31 CD cord-010119-t1x9gknd 2728 27 , , , cord-010119-t1x9gknd 2728 28 2016 2016 CD cord-010119-t1x9gknd 2728 29 . . . cord-010119-t1x9gknd 2729 1 No no DT cord-010119-t1x9gknd 2729 2 specific specific JJ cord-010119-t1x9gknd 2729 3 TEG TEG NNP cord-010119-t1x9gknd 2729 4 protocol protocol NN cord-010119-t1x9gknd 2729 5 was be VBD cord-010119-t1x9gknd 2729 6 used use VBN cord-010119-t1x9gknd 2729 7 to to TO cord-010119-t1x9gknd 2729 8 direct direct VB cord-010119-t1x9gknd 2729 9 transfusions transfusion NNS cord-010119-t1x9gknd 2729 10 ( ( -LRB- cord-010119-t1x9gknd 2729 11 plasma plasma NN cord-010119-t1x9gknd 2729 12 , , , cord-010119-t1x9gknd 2729 13 platelets platelet NNS cord-010119-t1x9gknd 2729 14 , , , cord-010119-t1x9gknd 2729 15 and and CC cord-010119-t1x9gknd 2729 16 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 2729 17 ) ) -RRB- cord-010119-t1x9gknd 2729 18 during during IN cord-010119-t1x9gknd 2729 19 that that DT cord-010119-t1x9gknd 2729 20 period period NN cord-010119-t1x9gknd 2729 21 . . . cord-010119-t1x9gknd 2730 1 Only only RB cord-010119-t1x9gknd 2730 2 the the DT cord-010119-t1x9gknd 2730 3 first first JJ cord-010119-t1x9gknd 2730 4 TEG TEG NNP cord-010119-t1x9gknd 2730 5 performed perform VBN cord-010119-t1x9gknd 2730 6 during during IN cord-010119-t1x9gknd 2730 7 surgery surgery NN cord-010119-t1x9gknd 2730 8 was be VBD cord-010119-t1x9gknd 2730 9 included include VBN cord-010119-t1x9gknd 2730 10 in in IN cord-010119-t1x9gknd 2730 11 the the DT cord-010119-t1x9gknd 2730 12 analysis analysis NN cord-010119-t1x9gknd 2730 13 . . . cord-010119-t1x9gknd 2731 1 We -PRON- PRP cord-010119-t1x9gknd 2731 2 excluded exclude VBD cord-010119-t1x9gknd 2731 3 the the DT cord-010119-t1x9gknd 2731 4 patients patient NNS cord-010119-t1x9gknd 2731 5 that that WDT cord-010119-t1x9gknd 2731 6 received receive VBD cord-010119-t1x9gknd 2731 7 only only RB cord-010119-t1x9gknd 2731 8 red red JJ cord-010119-t1x9gknd 2731 9 blood blood NN cord-010119-t1x9gknd 2731 10 cell cell NN cord-010119-t1x9gknd 2731 11 ( ( -LRB- cord-010119-t1x9gknd 2731 12 RBC RBC NNP cord-010119-t1x9gknd 2731 13 ) ) -RRB- cord-010119-t1x9gknd 2731 14 transfusions transfusion NNS cord-010119-t1x9gknd 2731 15 during during IN cord-010119-t1x9gknd 2731 16 the the DT cord-010119-t1x9gknd 2731 17 surgery surgery NN cord-010119-t1x9gknd 2731 18 because because IN cord-010119-t1x9gknd 2731 19 RBC RBC NNP cord-010119-t1x9gknd 2731 20 transfusions transfusion NNS cord-010119-t1x9gknd 2731 21 are be VBP cord-010119-t1x9gknd 2731 22 usually usually RB cord-010119-t1x9gknd 2731 23 not not RB cord-010119-t1x9gknd 2731 24 based base VBN cord-010119-t1x9gknd 2731 25 on on IN cord-010119-t1x9gknd 2731 26 TEG TEG NNP cord-010119-t1x9gknd 2731 27 results result NNS cord-010119-t1x9gknd 2731 28 . . . cord-010119-t1x9gknd 2732 1 For for IN cord-010119-t1x9gknd 2732 2 the the DT cord-010119-t1x9gknd 2732 3 56 56 CD cord-010119-t1x9gknd 2732 4 TEGs teg NNS cord-010119-t1x9gknd 2732 5 analyzed analyze VBD cord-010119-t1x9gknd 2732 6 , , , cord-010119-t1x9gknd 2732 7 TEG TEG NNP cord-010119-t1x9gknd 2732 8 results result NNS cord-010119-t1x9gknd 2732 9 were be VBD cord-010119-t1x9gknd 2732 10 divided divide VBN cord-010119-t1x9gknd 2732 11 into into IN cord-010119-t1x9gknd 2732 12 three three CD cord-010119-t1x9gknd 2732 13 categories category NNS cord-010119-t1x9gknd 2732 14 : : : cord-010119-t1x9gknd 2732 15 " " `` cord-010119-t1x9gknd 2732 16 normal normal JJ cord-010119-t1x9gknd 2732 17 " " '' cord-010119-t1x9gknd 2732 18 ( ( -LRB- cord-010119-t1x9gknd 2732 19 reaction reaction NN cord-010119-t1x9gknd 2732 20 time time NN cord-010119-t1x9gknd 2732 21 ( ( -LRB- cord-010119-t1x9gknd 2732 22 R r NN cord-010119-t1x9gknd 2732 23 ) ) -RRB- cord-010119-t1x9gknd 2732 24 , , , cord-010119-t1x9gknd 2732 25 kinetics kinetics NNP cord-010119-t1x9gknd 2732 26 ( ( -LRB- cord-010119-t1x9gknd 2732 27 K K NNP cord-010119-t1x9gknd 2732 28 ) ) -RRB- cord-010119-t1x9gknd 2732 29 , , , cord-010119-t1x9gknd 2732 30 angle angle NN cord-010119-t1x9gknd 2732 31 ( ( -LRB- cord-010119-t1x9gknd 2732 32 a a LS cord-010119-t1x9gknd 2732 33 ) ) -RRB- cord-010119-t1x9gknd 2732 34 , , , cord-010119-t1x9gknd 2732 35 maximum maximum JJ cord-010119-t1x9gknd 2732 36 amplitude amplitude NN cord-010119-t1x9gknd 2732 37 ( ( -LRB- cord-010119-t1x9gknd 2732 38 MA MA NNP cord-010119-t1x9gknd 2732 39 ) ) -RRB- cord-010119-t1x9gknd 2732 40 , , , cord-010119-t1x9gknd 2732 41 and and CC cord-010119-t1x9gknd 2732 42 lysis lysis NN cord-010119-t1x9gknd 2732 43 at at IN cord-010119-t1x9gknd 2732 44 30 30 CD cord-010119-t1x9gknd 2732 45 minutes minute NNS cord-010119-t1x9gknd 2732 46 ( ( -LRB- cord-010119-t1x9gknd 2732 47 min min NN cord-010119-t1x9gknd 2732 48 ) ) -RRB- cord-010119-t1x9gknd 2732 49 all all DT cord-010119-t1x9gknd 2732 50 within within IN cord-010119-t1x9gknd 2732 51 reference reference NN cord-010119-t1x9gknd 2732 52 range range NN cord-010119-t1x9gknd 2732 53 ) ) -RRB- cord-010119-t1x9gknd 2732 54 , , , cord-010119-t1x9gknd 2732 55 " " `` cord-010119-t1x9gknd 2732 56 hypocoagulable hypocoagulable NNP cord-010119-t1x9gknd 2732 57 " " '' cord-010119-t1x9gknd 2732 58 ( ( -LRB- cord-010119-t1x9gknd 2733 1 R>10 R>10 NNP cord-010119-t1x9gknd 2733 2 min min NNP cord-010119-t1x9gknd 2733 3 , , , cord-010119-t1x9gknd 2733 4 K>3 K>3 NNP cord-010119-t1x9gknd 2733 5 min min NNP cord-010119-t1x9gknd 2733 6 , , , cord-010119-t1x9gknd 2733 7 a<53 a<53 CD cord-010119-t1x9gknd 2733 8 degrees degree NNS cord-010119-t1x9gknd 2733 9 , , , cord-010119-t1x9gknd 2733 10 MA<50 MA<50 NNP cord-010119-t1x9gknd 2733 11 mm mm NNP cord-010119-t1x9gknd 2733 12 ) ) -RRB- cord-010119-t1x9gknd 2733 13 and and CC cord-010119-t1x9gknd 2733 14 " " `` cord-010119-t1x9gknd 2733 15 hypercoagulable hypercoagulable JJ cord-010119-t1x9gknd 2733 16 " " '' cord-010119-t1x9gknd 2733 17 ( ( -LRB- cord-010119-t1x9gknd 2733 18 R<5 R<5 NNP cord-010119-t1x9gknd 2733 19 min min NNP cord-010119-t1x9gknd 2733 20 , , , cord-010119-t1x9gknd 2733 21 K<1 K<1 NNP cord-010119-t1x9gknd 2733 22 min min NNP cord-010119-t1x9gknd 2733 23 , , , cord-010119-t1x9gknd 2733 24 a>72 a>72 JJ cord-010119-t1x9gknd 2733 25 degrees degree NNS cord-010119-t1x9gknd 2733 26 , , , cord-010119-t1x9gknd 2733 27 MA>70 MA>70 NNP cord-010119-t1x9gknd 2733 28 mm mm NNP cord-010119-t1x9gknd 2733 29 ) ) -RRB- cord-010119-t1x9gknd 2733 30 . . . cord-010119-t1x9gknd 2734 1 Fisher Fisher NNP cord-010119-t1x9gknd 2734 2 's 's POS cord-010119-t1x9gknd 2734 3 exact exact JJ cord-010119-t1x9gknd 2734 4 tests test NNS cord-010119-t1x9gknd 2734 5 and and CC cord-010119-t1x9gknd 2734 6 Z z NN cord-010119-t1x9gknd 2734 7 - - HYPH cord-010119-t1x9gknd 2734 8 scores score NNS cord-010119-t1x9gknd 2734 9 for for IN cord-010119-t1x9gknd 2734 10 two two CD cord-010119-t1x9gknd 2734 11 population population NN cord-010119-t1x9gknd 2734 12 proportions proportion NNS cord-010119-t1x9gknd 2734 13 were be VBD cord-010119-t1x9gknd 2734 14 used use VBN cord-010119-t1x9gknd 2734 15 to to TO cord-010119-t1x9gknd 2734 16 identify identify VB cord-010119-t1x9gknd 2734 17 statistically statistically RB cord-010119-t1x9gknd 2734 18 significant significant JJ cord-010119-t1x9gknd 2734 19 differences difference NNS cord-010119-t1x9gknd 2734 20 in in IN cord-010119-t1x9gknd 2734 21 TEG TEG NNP cord-010119-t1x9gknd 2734 22 results result NNS cord-010119-t1x9gknd 2734 23 and and CC cord-010119-t1x9gknd 2734 24 blood blood NN cord-010119-t1x9gknd 2734 25 product product NN cord-010119-t1x9gknd 2734 26 utilization utilization NN cord-010119-t1x9gknd 2734 27 . . . cord-010119-t1x9gknd 2735 1 Results result NNS cord-010119-t1x9gknd 2735 2 / / SYM cord-010119-t1x9gknd 2735 3 Finding finding NN cord-010119-t1x9gknd 2735 4 : : : cord-010119-t1x9gknd 2736 1 Out out IN cord-010119-t1x9gknd 2736 2 of of IN cord-010119-t1x9gknd 2736 3 56 56 CD cord-010119-t1x9gknd 2736 4 TEGs teg NNS cord-010119-t1x9gknd 2736 5 analyzed analyze VBN cord-010119-t1x9gknd 2736 6 , , , cord-010119-t1x9gknd 2736 7 37 37 CD cord-010119-t1x9gknd 2736 8 patients patient NNS cord-010119-t1x9gknd 2736 9 ( ( -LRB- cord-010119-t1x9gknd 2736 10 66 66 CD cord-010119-t1x9gknd 2736 11 % % NN cord-010119-t1x9gknd 2736 12 ) ) -RRB- cord-010119-t1x9gknd 2736 13 received receive VBD cord-010119-t1x9gknd 2736 14 pre pre JJ cord-010119-t1x9gknd 2736 15 - - JJ cord-010119-t1x9gknd 2736 16 TEG TEG NNP cord-010119-t1x9gknd 2736 17 transfusions transfusion NNS cord-010119-t1x9gknd 2736 18 . . . cord-010119-t1x9gknd 2737 1 We -PRON- PRP cord-010119-t1x9gknd 2737 2 found find VBD cord-010119-t1x9gknd 2737 3 significantly significantly RB cord-010119-t1x9gknd 2737 4 fewer few JJR cord-010119-t1x9gknd 2737 5 hypocoagulable hypocoagulable NNP cord-010119-t1x9gknd 2737 6 TEG TEG NNP cord-010119-t1x9gknd 2737 7 results result NNS cord-010119-t1x9gknd 2737 8 in in IN cord-010119-t1x9gknd 2737 9 pre pre JJ cord-010119-t1x9gknd 2737 10 - - JJ cord-010119-t1x9gknd 2737 11 TEG TEG NNP cord-010119-t1x9gknd 2737 12 transfused transfuse VBN cord-010119-t1x9gknd 2737 13 patients patient NNS cord-010119-t1x9gknd 2737 14 than than IN cord-010119-t1x9gknd 2737 15 nontransfused nontransfused JJ cord-010119-t1x9gknd 2737 16 patients patient NNS cord-010119-t1x9gknd 2737 17 ( ( -LRB- cord-010119-t1x9gknd 2737 18 8 8 CD cord-010119-t1x9gknd 2737 19 % % NN cord-010119-t1x9gknd 2737 20 vs. vs. IN cord-010119-t1x9gknd 2737 21 32 32 CD cord-010119-t1x9gknd 2737 22 % % NN cord-010119-t1x9gknd 2737 23 , , , cord-010119-t1x9gknd 2737 24 p50.02 p50.02 NNP cord-010119-t1x9gknd 2737 25 ) ) -RRB- cord-010119-t1x9gknd 2737 26 . . . cord-010119-t1x9gknd 2738 1 The the DT cord-010119-t1x9gknd 2738 2 data datum NNS cord-010119-t1x9gknd 2738 3 also also RB cord-010119-t1x9gknd 2738 4 reflected reflect VBD cord-010119-t1x9gknd 2738 5 a a DT cord-010119-t1x9gknd 2738 6 trend trend NN cord-010119-t1x9gknd 2738 7 suggesting suggest VBG cord-010119-t1x9gknd 2738 8 that that IN cord-010119-t1x9gknd 2738 9 there there EX cord-010119-t1x9gknd 2738 10 may may MD cord-010119-t1x9gknd 2738 11 be be VB cord-010119-t1x9gknd 2738 12 more more RBR cord-010119-t1x9gknd 2738 13 normal normal JJ cord-010119-t1x9gknd 2738 14 TEG TEG NNP cord-010119-t1x9gknd 2738 15 results result NNS cord-010119-t1x9gknd 2738 16 in in IN cord-010119-t1x9gknd 2738 17 pre pre JJ cord-010119-t1x9gknd 2738 18 - - JJ cord-010119-t1x9gknd 2738 19 TEG TEG NNP cord-010119-t1x9gknd 2738 20 transfused transfuse VBN cord-010119-t1x9gknd 2738 21 patients patient NNS cord-010119-t1x9gknd 2738 22 compared compare VBN cord-010119-t1x9gknd 2738 23 with with IN cord-010119-t1x9gknd 2738 24 nontransfused nontransfused JJ cord-010119-t1x9gknd 2738 25 ( ( -LRB- cord-010119-t1x9gknd 2738 26 32 32 CD cord-010119-t1x9gknd 2738 27 % % NN cord-010119-t1x9gknd 2738 28 vs. vs. IN cord-010119-t1x9gknd 2738 29 11 11 CD cord-010119-t1x9gknd 2738 30 % % NN cord-010119-t1x9gknd 2738 31 , , , cord-010119-t1x9gknd 2738 32 p50.07 p50.07 NNP cord-010119-t1x9gknd 2738 33 ) ) -RRB- cord-010119-t1x9gknd 2738 34 . . . cord-010119-t1x9gknd 2739 1 There there EX cord-010119-t1x9gknd 2739 2 was be VBD cord-010119-t1x9gknd 2739 3 no no DT cord-010119-t1x9gknd 2739 4 statistically statistically RB cord-010119-t1x9gknd 2739 5 significant significant JJ cord-010119-t1x9gknd 2739 6 difference difference NN cord-010119-t1x9gknd 2739 7 in in IN cord-010119-t1x9gknd 2739 8 transfusions transfusion NNS cord-010119-t1x9gknd 2739 9 after after IN cord-010119-t1x9gknd 2739 10 obtaining obtain VBG cord-010119-t1x9gknd 2739 11 TEG TEG NNP cord-010119-t1x9gknd 2739 12 results result NNS cord-010119-t1x9gknd 2739 13 in in IN cord-010119-t1x9gknd 2739 14 both both DT cord-010119-t1x9gknd 2739 15 groups group NNS cord-010119-t1x9gknd 2739 16 . . . cord-010119-t1x9gknd 2740 1 However however RB cord-010119-t1x9gknd 2740 2 , , , cord-010119-t1x9gknd 2740 3 there there EX cord-010119-t1x9gknd 2740 4 was be VBD cord-010119-t1x9gknd 2740 5 a a DT cord-010119-t1x9gknd 2740 6 trend trend NN cord-010119-t1x9gknd 2740 7 suggesting suggest VBG cord-010119-t1x9gknd 2740 8 that that IN cord-010119-t1x9gknd 2740 9 hypocoagulable hypocoagulable NNP cord-010119-t1x9gknd 2740 10 state state NN cord-010119-t1x9gknd 2740 11 was be VBD cord-010119-t1x9gknd 2740 12 more more RBR cord-010119-t1x9gknd 2740 13 likely likely JJ cord-010119-t1x9gknd 2740 14 to to TO cord-010119-t1x9gknd 2740 15 be be VB cord-010119-t1x9gknd 2740 16 corrected correct VBN cord-010119-t1x9gknd 2740 17 by by IN cord-010119-t1x9gknd 2740 18 transfusion transfusion NN cord-010119-t1x9gknd 2740 19 in in IN cord-010119-t1x9gknd 2740 20 patients patient NNS cord-010119-t1x9gknd 2740 21 who who WP cord-010119-t1x9gknd 2740 22 were be VBD cord-010119-t1x9gknd 2740 23 already already RB cord-010119-t1x9gknd 2740 24 transfused transfuse VBN cord-010119-t1x9gknd 2740 25 pre pre NNP cord-010119-t1x9gknd 2740 26 - - NNP cord-010119-t1x9gknd 2740 27 TEG TEG NNP cord-010119-t1x9gknd 2740 28 compared compare VBN cord-010119-t1x9gknd 2740 29 to to IN cord-010119-t1x9gknd 2740 30 nontransfused nontransfused NNP cord-010119-t1x9gknd 2740 31 ( ( -LRB- cord-010119-t1x9gknd 2740 32 100 100 CD cord-010119-t1x9gknd 2740 33 % % NN cord-010119-t1x9gknd 2740 34 versus versus IN cord-010119-t1x9gknd 2740 35 33 33 CD cord-010119-t1x9gknd 2740 36 % % NN cord-010119-t1x9gknd 2740 37 , , , cord-010119-t1x9gknd 2740 38 p50.06 p50.06 NNP cord-010119-t1x9gknd 2740 39 ) ) -RRB- cord-010119-t1x9gknd 2740 40 . . . cord-010119-t1x9gknd 2741 1 Conclusion conclusion NN cord-010119-t1x9gknd 2741 2 : : : cord-010119-t1x9gknd 2742 1 Pre Pre NNP cord-010119-t1x9gknd 2742 2 - - JJ cord-010119-t1x9gknd 2742 3 TEG TEG NNP cord-010119-t1x9gknd 2742 4 transfusions transfusion NNS cord-010119-t1x9gknd 2742 5 impact impact VBP cord-010119-t1x9gknd 2742 6 TEG TEG NNP cord-010119-t1x9gknd 2742 7 results result NNS cord-010119-t1x9gknd 2742 8 ( ( -LRB- cord-010119-t1x9gknd 2742 9 transfusions transfusion NNS cord-010119-t1x9gknd 2742 10 correct correct VBP cord-010119-t1x9gknd 2742 11 / / SYM cord-010119-t1x9gknd 2742 12 normalize normalize VBP cord-010119-t1x9gknd 2742 13 coagulopathy coagulopathy NN cord-010119-t1x9gknd 2742 14 ) ) -RRB- cord-010119-t1x9gknd 2742 15 but but CC cord-010119-t1x9gknd 2742 16 do do VBP cord-010119-t1x9gknd 2742 17 not not RB cord-010119-t1x9gknd 2742 18 significantly significantly RB cord-010119-t1x9gknd 2742 19 impact impact VB cord-010119-t1x9gknd 2742 20 further further JJ cord-010119-t1x9gknd 2742 21 blood blood NN cord-010119-t1x9gknd 2742 22 product product NN cord-010119-t1x9gknd 2742 23 utilization utilization NN cord-010119-t1x9gknd 2742 24 during during IN cord-010119-t1x9gknd 2742 25 CV CV NNP cord-010119-t1x9gknd 2742 26 surgeries surgery NNS cord-010119-t1x9gknd 2742 27 . . . cord-010119-t1x9gknd 2743 1 The the DT cord-010119-t1x9gknd 2743 2 decreased decreased JJ cord-010119-t1x9gknd 2743 3 threshold threshold NN cord-010119-t1x9gknd 2743 4 ( ( -LRB- cord-010119-t1x9gknd 2743 5 more more JJR cord-010119-t1x9gknd 2743 6 transfusions transfusion NNS cord-010119-t1x9gknd 2743 7 ) ) -RRB- cord-010119-t1x9gknd 2743 8 for for IN cord-010119-t1x9gknd 2743 9 correcting correct VBG cord-010119-t1x9gknd 2743 10 hypocoagulable hypocoagulable NNP cord-010119-t1x9gknd 2743 11 state state NN cord-010119-t1x9gknd 2743 12 in in IN cord-010119-t1x9gknd 2743 13 patients patient NNS cord-010119-t1x9gknd 2743 14 who who WP cord-010119-t1x9gknd 2743 15 already already RB cord-010119-t1x9gknd 2743 16 received receive VBD cord-010119-t1x9gknd 2743 17 pre pre JJ cord-010119-t1x9gknd 2743 18 - - JJ cord-010119-t1x9gknd 2743 19 TEG TEG NNP cord-010119-t1x9gknd 2743 20 transfusions transfusion NNS cord-010119-t1x9gknd 2743 21 may may MD cord-010119-t1x9gknd 2743 22 be be VB cord-010119-t1x9gknd 2743 23 due due JJ cord-010119-t1x9gknd 2743 24 to to IN cord-010119-t1x9gknd 2743 25 more more RBR cord-010119-t1x9gknd 2743 26 clinical clinical JJ cord-010119-t1x9gknd 2743 27 significant significant JJ cord-010119-t1x9gknd 2743 28 bleeding bleeding NN cord-010119-t1x9gknd 2743 29 in in IN cord-010119-t1x9gknd 2743 30 these these DT cord-010119-t1x9gknd 2743 31 patients patient NNS cord-010119-t1x9gknd 2743 32 to to TO cord-010119-t1x9gknd 2743 33 begin begin VB cord-010119-t1x9gknd 2743 34 with with IN cord-010119-t1x9gknd 2743 35 . . . cord-010119-t1x9gknd 2744 1 Background Background NNP cord-010119-t1x9gknd 2744 2 / / SYM cord-010119-t1x9gknd 2744 3 Case Case NNP cord-010119-t1x9gknd 2744 4 Studies Studies NNPS cord-010119-t1x9gknd 2744 5 : : : cord-010119-t1x9gknd 2745 1 Orthotopic Orthotopic NNP cord-010119-t1x9gknd 2745 2 liver liver NN cord-010119-t1x9gknd 2745 3 transplantation transplantation NN cord-010119-t1x9gknd 2745 4 ( ( -LRB- cord-010119-t1x9gknd 2745 5 OLT OLT NNP cord-010119-t1x9gknd 2745 6 ) ) -RRB- cord-010119-t1x9gknd 2745 7 is be VBZ cord-010119-t1x9gknd 2745 8 associated associate VBN cord-010119-t1x9gknd 2745 9 with with IN cord-010119-t1x9gknd 2745 10 significant significant JJ cord-010119-t1x9gknd 2745 11 blood blood NN cord-010119-t1x9gknd 2745 12 loss loss NN cord-010119-t1x9gknd 2745 13 , , , cord-010119-t1x9gknd 2745 14 due due IN cord-010119-t1x9gknd 2745 15 to to IN cord-010119-t1x9gknd 2745 16 the the DT cord-010119-t1x9gknd 2745 17 complexity complexity NN cord-010119-t1x9gknd 2745 18 of of IN cord-010119-t1x9gknd 2745 19 the the DT cord-010119-t1x9gknd 2745 20 procedure procedure NN cord-010119-t1x9gknd 2745 21 and and CC cord-010119-t1x9gknd 2745 22 extensive extensive JJ cord-010119-t1x9gknd 2745 23 liver liver NN cord-010119-t1x9gknd 2745 24 vascularity vascularity NN cord-010119-t1x9gknd 2745 25 , , , cord-010119-t1x9gknd 2745 26 demanding demand VBG cord-010119-t1x9gknd 2745 27 blood blood NN cord-010119-t1x9gknd 2745 28 transfusion transfusion NN cord-010119-t1x9gknd 2745 29 . . . cord-010119-t1x9gknd 2746 1 In in IN cord-010119-t1x9gknd 2746 2 this this DT cord-010119-t1x9gknd 2746 3 setting setting NN cord-010119-t1x9gknd 2746 4 , , , cord-010119-t1x9gknd 2746 5 cell cell NN cord-010119-t1x9gknd 2746 6 salvage salvage NN cord-010119-t1x9gknd 2746 7 autotransfusion autotransfusion NN cord-010119-t1x9gknd 2746 8 ( ( -LRB- cord-010119-t1x9gknd 2746 9 CS CS NNP cord-010119-t1x9gknd 2746 10 ) ) -RRB- cord-010119-t1x9gknd 2746 11 is be VBZ cord-010119-t1x9gknd 2746 12 been be VBN cord-010119-t1x9gknd 2746 13 used use VBN cord-010119-t1x9gknd 2746 14 as as IN cord-010119-t1x9gknd 2746 15 an an DT cord-010119-t1x9gknd 2746 16 alternative alternative NN cord-010119-t1x9gknd 2746 17 to to TO cord-010119-t1x9gknd 2746 18 decrease decrease VB cord-010119-t1x9gknd 2746 19 allogeneic allogeneic IN cord-010119-t1x9gknd 2746 20 red red JJ cord-010119-t1x9gknd 2746 21 blood blood NN cord-010119-t1x9gknd 2746 22 cell cell NN cord-010119-t1x9gknd 2746 23 transfusion transfusion NN cord-010119-t1x9gknd 2746 24 . . . cord-010119-t1x9gknd 2747 1 However however RB cord-010119-t1x9gknd 2747 2 , , , cord-010119-t1x9gknd 2747 3 as as RB cord-010119-t1x9gknd 2747 4 long long RB cord-010119-t1x9gknd 2747 5 as as IN cord-010119-t1x9gknd 2747 6 some some DT cord-010119-t1x9gknd 2747 7 studies study NNS cord-010119-t1x9gknd 2747 8 have have VBP cord-010119-t1x9gknd 2747 9 shown show VBN cord-010119-t1x9gknd 2747 10 that that IN cord-010119-t1x9gknd 2747 11 CS CS NNP cord-010119-t1x9gknd 2747 12 in in IN cord-010119-t1x9gknd 2747 13 OLT OLT NNP cord-010119-t1x9gknd 2747 14 decreases decrease VBZ cord-010119-t1x9gknd 2747 15 allogeneic allogeneic IN cord-010119-t1x9gknd 2747 16 blood blood NN cord-010119-t1x9gknd 2747 17 transfusion transfusion NN cord-010119-t1x9gknd 2747 18 , , , cord-010119-t1x9gknd 2747 19 others other NNS cord-010119-t1x9gknd 2747 20 reported report VBD cord-010119-t1x9gknd 2747 21 that that IN cord-010119-t1x9gknd 2747 22 CS CS NNP cord-010119-t1x9gknd 2747 23 presented present VBD cord-010119-t1x9gknd 2747 24 little little JJ cord-010119-t1x9gknd 2747 25 benefit benefit NN cord-010119-t1x9gknd 2747 26 or or CC cord-010119-t1x9gknd 2747 27 might may MD cord-010119-t1x9gknd 2747 28 have have VB cord-010119-t1x9gknd 2747 29 been be VBN cord-010119-t1x9gknd 2747 30 associated associate VBN cord-010119-t1x9gknd 2747 31 with with IN cord-010119-t1x9gknd 2747 32 increased increase VBN cord-010119-t1x9gknd 2747 33 blood blood NN cord-010119-t1x9gknd 2747 34 loss loss NN cord-010119-t1x9gknd 2747 35 through through IN cord-010119-t1x9gknd 2747 36 fibrinolysis fibrinolysis NN cord-010119-t1x9gknd 2747 37 . . . cord-010119-t1x9gknd 2748 1 In in IN cord-010119-t1x9gknd 2748 2 this this DT cord-010119-t1x9gknd 2748 3 study study NN cord-010119-t1x9gknd 2748 4 , , , cord-010119-t1x9gknd 2748 5 we -PRON- PRP cord-010119-t1x9gknd 2748 6 evaluate evaluate VBP cord-010119-t1x9gknd 2748 7 CS CS NNP cord-010119-t1x9gknd 2748 8 efficacy efficacy NN cord-010119-t1x9gknd 2748 9 in in IN cord-010119-t1x9gknd 2748 10 reducing reduce VBG cord-010119-t1x9gknd 2748 11 allogeneic allogeneic JJ cord-010119-t1x9gknd 2748 12 blood blood NN cord-010119-t1x9gknd 2748 13 transfusion transfusion NN cord-010119-t1x9gknd 2748 14 in in IN cord-010119-t1x9gknd 2748 15 the the DT cord-010119-t1x9gknd 2748 16 intraoperative intraoperative JJ cord-010119-t1x9gknd 2748 17 period period NN cord-010119-t1x9gknd 2748 18 . . . cord-010119-t1x9gknd 2749 1 Study Study NNP cord-010119-t1x9gknd 2749 2 Design Design NNP cord-010119-t1x9gknd 2749 3 / / SYM cord-010119-t1x9gknd 2749 4 Method method NN cord-010119-t1x9gknd 2749 5 : : : cord-010119-t1x9gknd 2749 6 We -PRON- PRP cord-010119-t1x9gknd 2749 7 retrospectively retrospectively RB cord-010119-t1x9gknd 2749 8 evaluated evaluate VBD cord-010119-t1x9gknd 2749 9 data datum NNS cord-010119-t1x9gknd 2749 10 from from IN cord-010119-t1x9gknd 2749 11 670 670 CD cord-010119-t1x9gknd 2749 12 liver liver NN cord-010119-t1x9gknd 2749 13 transplants transplant NNS cord-010119-t1x9gknd 2749 14 , , , cord-010119-t1x9gknd 2749 15 performed perform VBN cord-010119-t1x9gknd 2749 16 from from IN cord-010119-t1x9gknd 2749 17 2011 2011 CD cord-010119-t1x9gknd 2749 18 to to IN cord-010119-t1x9gknd 2749 19 2015 2015 CD cord-010119-t1x9gknd 2749 20 in in IN cord-010119-t1x9gknd 2749 21 a a DT cord-010119-t1x9gknd 2749 22 single single JJ cord-010119-t1x9gknd 2749 23 - - HYPH cord-010119-t1x9gknd 2749 24 center center NN cord-010119-t1x9gknd 2749 25 . . . cord-010119-t1x9gknd 2750 1 Patients patient NNS cord-010119-t1x9gknd 2750 2 were be VBD cord-010119-t1x9gknd 2750 3 divided divide VBN cord-010119-t1x9gknd 2750 4 in in IN cord-010119-t1x9gknd 2750 5 two two CD cord-010119-t1x9gknd 2750 6 groups group NNS cord-010119-t1x9gknd 2750 7 : : : cord-010119-t1x9gknd 2750 8 one one CD cord-010119-t1x9gknd 2750 9 with with IN cord-010119-t1x9gknd 2750 10 cell cell NN cord-010119-t1x9gknd 2750 11 salvage salvage NN cord-010119-t1x9gknd 2750 12 ( ( -LRB- cord-010119-t1x9gknd 2750 13 CS CS NNP cord-010119-t1x9gknd 2750 14 ) ) -RRB- cord-010119-t1x9gknd 2750 15 and and CC cord-010119-t1x9gknd 2750 16 another another DT cord-010119-t1x9gknd 2750 17 without without IN cord-010119-t1x9gknd 2750 18 CS CS NNP cord-010119-t1x9gknd 2750 19 ( ( -LRB- cord-010119-t1x9gknd 2750 20 NCS NCS NNP cord-010119-t1x9gknd 2750 21 ) ) -RRB- cord-010119-t1x9gknd 2750 22 . . . cord-010119-t1x9gknd 2751 1 Study study NN cord-010119-t1x9gknd 2751 2 endpoint endpoint NN cord-010119-t1x9gknd 2751 3 included include VBD cord-010119-t1x9gknd 2751 4 the the DT cord-010119-t1x9gknd 2751 5 requirement requirement NN cord-010119-t1x9gknd 2751 6 of of IN cord-010119-t1x9gknd 2751 7 allogeneic allogeneic JJ cord-010119-t1x9gknd 2751 8 blood blood NN cord-010119-t1x9gknd 2751 9 components component NNS cord-010119-t1x9gknd 2751 10 transfusion transfusion NN cord-010119-t1x9gknd 2751 11 during during IN cord-010119-t1x9gknd 2751 12 intraoperative intraoperative JJ cord-010119-t1x9gknd 2751 13 period period NN cord-010119-t1x9gknd 2751 14 in in IN cord-010119-t1x9gknd 2751 15 both both DT cord-010119-t1x9gknd 2751 16 groups group NNS cord-010119-t1x9gknd 2751 17 . . . cord-010119-t1x9gknd 2752 1 CS CS NNP cord-010119-t1x9gknd 2752 2 was be VBD cord-010119-t1x9gknd 2752 3 used use VBN cord-010119-t1x9gknd 2752 4 in in IN cord-010119-t1x9gknd 2752 5 all all DT cord-010119-t1x9gknd 2752 6 liver liver NN cord-010119-t1x9gknd 2752 7 transplant transplant NN cord-010119-t1x9gknd 2752 8 recipients recipient NNS cord-010119-t1x9gknd 2752 9 but but CC cord-010119-t1x9gknd 2752 10 patients patient NNS cord-010119-t1x9gknd 2752 11 with with IN cord-010119-t1x9gknd 2752 12 malignancy malignancy NN cord-010119-t1x9gknd 2752 13 and and CC cord-010119-t1x9gknd 2752 14 sepsis sepsis NN cord-010119-t1x9gknd 2752 15 . . . cord-010119-t1x9gknd 2753 1 Blood blood NN cord-010119-t1x9gknd 2753 2 transfusions transfusion NNS cord-010119-t1x9gknd 2753 3 were be VBD cord-010119-t1x9gknd 2753 4 indicated indicate VBN cord-010119-t1x9gknd 2753 5 based base VBN cord-010119-t1x9gknd 2753 6 on on IN cord-010119-t1x9gknd 2753 7 clinical clinical JJ cord-010119-t1x9gknd 2753 8 and and CC cord-010119-t1x9gknd 2753 9 hemodynamic hemodynamic JJ cord-010119-t1x9gknd 2753 10 criteria criterion NNS cord-010119-t1x9gknd 2753 11 . . . cord-010119-t1x9gknd 2754 1 Clinical clinical JJ cord-010119-t1x9gknd 2754 2 data datum NNS cord-010119-t1x9gknd 2754 3 included include VBD cord-010119-t1x9gknd 2754 4 age age NN cord-010119-t1x9gknd 2754 5 , , , cord-010119-t1x9gknd 2754 6 gender gender NN cord-010119-t1x9gknd 2754 7 , , , cord-010119-t1x9gknd 2754 8 diagnosis diagnosis NN cord-010119-t1x9gknd 2754 9 , , , cord-010119-t1x9gknd 2754 10 body body NN cord-010119-t1x9gknd 2754 11 weight weight NN cord-010119-t1x9gknd 2754 12 , , , cord-010119-t1x9gknd 2754 13 height height NN cord-010119-t1x9gknd 2754 14 , , , cord-010119-t1x9gknd 2754 15 warm warm JJ cord-010119-t1x9gknd 2754 16 and and CC cord-010119-t1x9gknd 2754 17 cold cold JJ cord-010119-t1x9gknd 2754 18 ischemic ischemic JJ cord-010119-t1x9gknd 2754 19 time time NN cord-010119-t1x9gknd 2754 20 and and CC cord-010119-t1x9gknd 2754 21 Model Model NNP cord-010119-t1x9gknd 2754 22 for for IN cord-010119-t1x9gknd 2754 23 End end NN cord-010119-t1x9gknd 2754 24 - - HYPH cord-010119-t1x9gknd 2754 25 Stage stage NN cord-010119-t1x9gknd 2754 26 Liver liver NN cord-010119-t1x9gknd 2754 27 Disease Disease NNP cord-010119-t1x9gknd 2754 28 ( ( -LRB- cord-010119-t1x9gknd 2754 29 MELD meld VB cord-010119-t1x9gknd 2754 30 ) ) -RRB- cord-010119-t1x9gknd 2754 31 score score NN cord-010119-t1x9gknd 2754 32 . . . cord-010119-t1x9gknd 2755 1 Statistical statistical JJ cord-010119-t1x9gknd 2755 2 analyses analysis NNS cord-010119-t1x9gknd 2755 3 were be VBD cord-010119-t1x9gknd 2755 4 performed perform VBN cord-010119-t1x9gknd 2755 5 using use VBG cord-010119-t1x9gknd 2755 6 t t NN cord-010119-t1x9gknd 2755 7 - - HYPH cord-010119-t1x9gknd 2755 8 test test NN cord-010119-t1x9gknd 2755 9 , , , cord-010119-t1x9gknd 2755 10 Chi Chi NNP cord-010119-t1x9gknd 2755 11 - - HYPH cord-010119-t1x9gknd 2755 12 square square JJ cord-010119-t1x9gknd 2755 13 test test NN cord-010119-t1x9gknd 2755 14 , , , cord-010119-t1x9gknd 2755 15 Mann Mann NNP cord-010119-t1x9gknd 2755 16 Whitney Whitney NNP cord-010119-t1x9gknd 2755 17 test test NN cord-010119-t1x9gknd 2755 18 . . . cord-010119-t1x9gknd 2756 1 Results result NNS cord-010119-t1x9gknd 2756 2 / / SYM cord-010119-t1x9gknd 2756 3 Finding finding NN cord-010119-t1x9gknd 2756 4 : : : cord-010119-t1x9gknd 2757 1 In in IN cord-010119-t1x9gknd 2757 2 this this DT cord-010119-t1x9gknd 2757 3 study study NN cord-010119-t1x9gknd 2757 4 period period NN cord-010119-t1x9gknd 2757 5 , , , cord-010119-t1x9gknd 2757 6 670 670 CD cord-010119-t1x9gknd 2757 7 OLTs olt NNS cord-010119-t1x9gknd 2757 8 were be VBD cord-010119-t1x9gknd 2757 9 performed perform VBN cord-010119-t1x9gknd 2757 10 . . . cord-010119-t1x9gknd 2758 1 A a DT cord-010119-t1x9gknd 2758 2 total total NN cord-010119-t1x9gknd 2758 3 of of IN cord-010119-t1x9gknd 2758 4 345 345 CD cord-010119-t1x9gknd 2758 5 patients patient NNS cord-010119-t1x9gknd 2758 6 was be VBD cord-010119-t1x9gknd 2758 7 submitted submit VBN cord-010119-t1x9gknd 2758 8 to to IN cord-010119-t1x9gknd 2758 9 CS CS NNP cord-010119-t1x9gknd 2758 10 . . . cord-010119-t1x9gknd 2759 1 The the DT cord-010119-t1x9gknd 2759 2 median median JJ cord-010119-t1x9gknd 2759 3 age age NN cord-010119-t1x9gknd 2759 4 was be VBD cord-010119-t1x9gknd 2759 5 51 51 CD cord-010119-t1x9gknd 2759 6 years year NNS cord-010119-t1x9gknd 2760 1 ( ( -LRB- cord-010119-t1x9gknd 2760 2 range range NNP cord-010119-t1x9gknd 2760 3 10 10 CD cord-010119-t1x9gknd 2760 4 - - SYM cord-010119-t1x9gknd 2760 5 78 78 CD cord-010119-t1x9gknd 2760 6 yo yo NN cord-010119-t1x9gknd 2760 7 ) ) -RRB- cord-010119-t1x9gknd 2760 8 . . . cord-010119-t1x9gknd 2761 1 Cirrhosis cirrhosis NN cord-010119-t1x9gknd 2761 2 caused cause VBN cord-010119-t1x9gknd 2761 3 by by IN cord-010119-t1x9gknd 2761 4 chronic chronic JJ cord-010119-t1x9gknd 2761 5 hepatitis hepatitis NN cord-010119-t1x9gknd 2761 6 C c NN cord-010119-t1x9gknd 2761 7 virus virus NN cord-010119-t1x9gknd 2761 8 infection infection NN cord-010119-t1x9gknd 2761 9 was be VBD cord-010119-t1x9gknd 2761 10 the the DT cord-010119-t1x9gknd 2761 11 main main JJ cord-010119-t1x9gknd 2761 12 etiology etiology NN cord-010119-t1x9gknd 2761 13 of of IN cord-010119-t1x9gknd 2761 14 liver liver NN cord-010119-t1x9gknd 2761 15 disease disease NN cord-010119-t1x9gknd 2761 16 . . . cord-010119-t1x9gknd 2762 1 Hepatocellular hepatocellular JJ cord-010119-t1x9gknd 2762 2 carcinoma carcinoma NN cord-010119-t1x9gknd 2762 3 ( ( -LRB- cord-010119-t1x9gknd 2762 4 HCC HCC NNP cord-010119-t1x9gknd 2762 5 ) ) -RRB- cord-010119-t1x9gknd 2762 6 was be VBD cord-010119-t1x9gknd 2762 7 found find VBN cord-010119-t1x9gknd 2762 8 in in IN cord-010119-t1x9gknd 2762 9 31,6 31,6 CD cord-010119-t1x9gknd 2762 10 % % NN cord-010119-t1x9gknd 2762 11 of of IN cord-010119-t1x9gknd 2762 12 the the DT cord-010119-t1x9gknd 2762 13 patients patient NNS cord-010119-t1x9gknd 2762 14 . . . cord-010119-t1x9gknd 2763 1 The the DT cord-010119-t1x9gknd 2763 2 average average JJ cord-010119-t1x9gknd 2763 3 MELD MELD NNP cord-010119-t1x9gknd 2763 4 score score NN cord-010119-t1x9gknd 2763 5 was be VBD cord-010119-t1x9gknd 2763 6 29,6 29,6 CD cord-010119-t1x9gknd 2763 7 6 6 CD cord-010119-t1x9gknd 2763 8 9,4 9,4 CD cord-010119-t1x9gknd 2763 9 and and CC cord-010119-t1x9gknd 2763 10 it -PRON- PRP cord-010119-t1x9gknd 2763 11 was be VBD cord-010119-t1x9gknd 2763 12 slightly slightly RB cord-010119-t1x9gknd 2763 13 higher high JJR cord-010119-t1x9gknd 2763 14 in in IN cord-010119-t1x9gknd 2763 15 the the DT cord-010119-t1x9gknd 2763 16 CS CS NNP cord-010119-t1x9gknd 2763 17 group group NN cord-010119-t1x9gknd 2763 18 ( ( -LRB- cord-010119-t1x9gknd 2763 19 31,3 31,3 CD cord-010119-t1x9gknd 2763 20 vs vs IN cord-010119-t1x9gknd 2763 21 27,9 27,9 CD cord-010119-t1x9gknd 2763 22 , , , cord-010119-t1x9gknd 2763 23 p<0,001 p<0,001 NNP cord-010119-t1x9gknd 2763 24 ) ) -RRB- cord-010119-t1x9gknd 2763 25 . . . cord-010119-t1x9gknd 2764 1 There there EX cord-010119-t1x9gknd 2764 2 was be VBD cord-010119-t1x9gknd 2764 3 no no DT cord-010119-t1x9gknd 2764 4 statistically statistically RB cord-010119-t1x9gknd 2764 5 significant significant JJ cord-010119-t1x9gknd 2764 6 difference difference NN cord-010119-t1x9gknd 2764 7 in in IN cord-010119-t1x9gknd 2764 8 other other JJ cord-010119-t1x9gknd 2764 9 variables variable NNS cord-010119-t1x9gknd 2764 10 such such JJ cord-010119-t1x9gknd 2764 11 as as IN cord-010119-t1x9gknd 2764 12 body body NN cord-010119-t1x9gknd 2764 13 weight weight NN cord-010119-t1x9gknd 2764 14 , , , cord-010119-t1x9gknd 2764 15 height height NN cord-010119-t1x9gknd 2764 16 and and CC cord-010119-t1x9gknd 2764 17 cold cold JJ cord-010119-t1x9gknd 2764 18 ischemic ischemic JJ cord-010119-t1x9gknd 2764 19 time time NN cord-010119-t1x9gknd 2764 20 . . . cord-010119-t1x9gknd 2765 1 The the DT cord-010119-t1x9gknd 2765 2 mean mean NN cord-010119-t1x9gknd 2765 3 salvaged salvage VBD cord-010119-t1x9gknd 2765 4 blood blood NN cord-010119-t1x9gknd 2765 5 volume volume NN cord-010119-t1x9gknd 2765 6 was be VBD cord-010119-t1x9gknd 2765 7 8856 8856 CD cord-010119-t1x9gknd 2765 8 6 6 CD cord-010119-t1x9gknd 2765 9 4503 4503 CD cord-010119-t1x9gknd 2765 10 ml ml NNS cord-010119-t1x9gknd 2765 11 and and CC cord-010119-t1x9gknd 2765 12 mean mean VB cord-010119-t1x9gknd 2765 13 reinfused reinfused JJ cord-010119-t1x9gknd 2765 14 blood blood NN cord-010119-t1x9gknd 2765 15 volume volume NN cord-010119-t1x9gknd 2765 16 was be VBD cord-010119-t1x9gknd 2765 17 914 914 CD cord-010119-t1x9gknd 2765 18 6909 6909 CD cord-010119-t1x9gknd 2765 19 ml ml NN cord-010119-t1x9gknd 2765 20 . . . cord-010119-t1x9gknd 2766 1 Allogeneic allogeneic IN cord-010119-t1x9gknd 2766 2 blood blood NN cord-010119-t1x9gknd 2766 3 transfusion transfusion NN cord-010119-t1x9gknd 2766 4 was be VBD cord-010119-t1x9gknd 2766 5 required require VBN cord-010119-t1x9gknd 2766 6 in in IN cord-010119-t1x9gknd 2766 7 71,8 71,8 CD cord-010119-t1x9gknd 2766 8 % % NN cord-010119-t1x9gknd 2766 9 patients patient NNS cord-010119-t1x9gknd 2766 10 in in IN cord-010119-t1x9gknd 2766 11 the the DT cord-010119-t1x9gknd 2766 12 CS CS NNP cord-010119-t1x9gknd 2766 13 group group NN cord-010119-t1x9gknd 2766 14 , , , cord-010119-t1x9gknd 2766 15 compared compare VBN cord-010119-t1x9gknd 2766 16 to to IN cord-010119-t1x9gknd 2766 17 46,7 46,7 CD cord-010119-t1x9gknd 2766 18 % % NN cord-010119-t1x9gknd 2766 19 patients patient NNS cord-010119-t1x9gknd 2766 20 in in IN cord-010119-t1x9gknd 2766 21 the the DT cord-010119-t1x9gknd 2766 22 NCS NCS NNP cord-010119-t1x9gknd 2766 23 group group NN cord-010119-t1x9gknd 2766 24 . . . cord-010119-t1x9gknd 2767 1 However however RB cord-010119-t1x9gknd 2767 2 , , , cord-010119-t1x9gknd 2767 3 average average JJ cord-010119-t1x9gknd 2767 4 red red JJ cord-010119-t1x9gknd 2767 5 blood blood NN cord-010119-t1x9gknd 2767 6 cells cell NNS cord-010119-t1x9gknd 2767 7 ( ( -LRB- cord-010119-t1x9gknd 2767 8 RBC RBC NNP cord-010119-t1x9gknd 2767 9 ) ) -RRB- cord-010119-t1x9gknd 2767 10 and and CC cord-010119-t1x9gknd 2767 11 fresh fresh JJ cord-010119-t1x9gknd 2767 12 frozen frozen JJ cord-010119-t1x9gknd 2767 13 plasma plasma NN cord-010119-t1x9gknd 2767 14 ( ( -LRB- cord-010119-t1x9gknd 2767 15 FFP FFP NNP cord-010119-t1x9gknd 2767 16 ) ) -RRB- cord-010119-t1x9gknd 2767 17 units unit NNS cord-010119-t1x9gknd 2767 18 transfused transfuse VBN cord-010119-t1x9gknd 2767 19 were be VBD cord-010119-t1x9gknd 2767 20 lower low JJR cord-010119-t1x9gknd 2767 21 in in IN cord-010119-t1x9gknd 2767 22 the the DT cord-010119-t1x9gknd 2767 23 CS CS NNP cord-010119-t1x9gknd 2767 24 group group NN cord-010119-t1x9gknd 2767 25 . . . cord-010119-t1x9gknd 2768 1 The the DT cord-010119-t1x9gknd 2768 2 threshold threshold NN cord-010119-t1x9gknd 2768 3 for for IN cord-010119-t1x9gknd 2768 4 RBC RBC NNP cord-010119-t1x9gknd 2768 5 transfusion transfusion NN cord-010119-t1x9gknd 2768 6 was be VBD cord-010119-t1x9gknd 2768 7 significantly significantly RB cord-010119-t1x9gknd 2768 8 lower low JJR cord-010119-t1x9gknd 2768 9 in in IN cord-010119-t1x9gknd 2768 10 the the DT cord-010119-t1x9gknd 2768 11 CS CS NNP cord-010119-t1x9gknd 2768 12 group group NN cord-010119-t1x9gknd 2768 13 ( ( -LRB- cord-010119-t1x9gknd 2768 14 2,4 2,4 CD cord-010119-t1x9gknd 2768 15 units unit NNS cord-010119-t1x9gknd 2768 16 vs vs IN cord-010119-t1x9gknd 2768 17 3,39 3,39 CD cord-010119-t1x9gknd 2768 18 units unit NNS cord-010119-t1x9gknd 2768 19 , , , cord-010119-t1x9gknd 2768 20 p<0,001 p<0,001 NNP cord-010119-t1x9gknd 2768 21 Background Background NNP cord-010119-t1x9gknd 2768 22 / / SYM cord-010119-t1x9gknd 2768 23 Case Case NNP cord-010119-t1x9gknd 2768 24 Studies Studies NNPS cord-010119-t1x9gknd 2768 25 : : : cord-010119-t1x9gknd 2768 26 Hemorrhage hemorrhage NN cord-010119-t1x9gknd 2768 27 is be VBZ cord-010119-t1x9gknd 2768 28 a a DT cord-010119-t1x9gknd 2768 29 leading leading JJ cord-010119-t1x9gknd 2768 30 cause cause NN cord-010119-t1x9gknd 2768 31 of of IN cord-010119-t1x9gknd 2768 32 mortality mortality NN cord-010119-t1x9gknd 2768 33 in in IN cord-010119-t1x9gknd 2768 34 trauma trauma NN cord-010119-t1x9gknd 2768 35 patients patient NNS cord-010119-t1x9gknd 2768 36 and and CC cord-010119-t1x9gknd 2768 37 morbidity morbidity NN cord-010119-t1x9gknd 2768 38 in in IN cord-010119-t1x9gknd 2768 39 non non JJ cord-010119-t1x9gknd 2768 40 - - JJ cord-010119-t1x9gknd 2768 41 trauma trauma JJ cord-010119-t1x9gknd 2768 42 patientsADDIN patientsaddin NN cord-010119-t1x9gknd 2768 43 EN.CITE.DATA EN.CITE.DATA NNP cord-010119-t1x9gknd 2768 44 . . . cord-010119-t1x9gknd 2769 1 Massive massive JJ cord-010119-t1x9gknd 2769 2 transfusion transfusion NN cord-010119-t1x9gknd 2769 3 protocols protocol NNS cord-010119-t1x9gknd 2769 4 ( ( -LRB- cord-010119-t1x9gknd 2769 5 MTP MTP NNP cord-010119-t1x9gknd 2769 6 ) ) -RRB- cord-010119-t1x9gknd 2769 7 reduce reduce VBP cord-010119-t1x9gknd 2769 8 mortality mortality NN cord-010119-t1x9gknd 2769 9 in in IN cord-010119-t1x9gknd 2769 10 trauma trauma NN cord-010119-t1x9gknd 2769 11 and and CC cord-010119-t1x9gknd 2769 12 nontrauma nontrauma NN cord-010119-t1x9gknd 2769 13 settings setting NNS cord-010119-t1x9gknd 2769 14 ; ; : cord-010119-t1x9gknd 2769 15 however however RB cord-010119-t1x9gknd 2769 16 , , , cord-010119-t1x9gknd 2769 17 this this DT cord-010119-t1x9gknd 2769 18 may may MD cord-010119-t1x9gknd 2769 19 be be VB cord-010119-t1x9gknd 2769 20 at at IN cord-010119-t1x9gknd 2769 21 the the DT cord-010119-t1x9gknd 2769 22 cost cost NN cord-010119-t1x9gknd 2769 23 of of IN cord-010119-t1x9gknd 2769 24 blood blood NN cord-010119-t1x9gknd 2769 25 product product NN cord-010119-t1x9gknd 2769 26 wasta wasta NN cord-010119-t1x9gknd 2769 27 - - HYPH cord-010119-t1x9gknd 2769 28 geADDIN geADDIN NNP cord-010119-t1x9gknd 2769 29 EN.CITE.DATA EN.CITE.DATA NNP cord-010119-t1x9gknd 2769 30 . . . cord-010119-t1x9gknd 2770 1 Blood blood NN cord-010119-t1x9gknd 2770 2 product product NN cord-010119-t1x9gknd 2770 3 wastage wastage NN cord-010119-t1x9gknd 2770 4 benchmarks benchmark NNS cord-010119-t1x9gknd 2770 5 are be VBP cord-010119-t1x9gknd 2770 6 loosely loosely RB cord-010119-t1x9gknd 2770 7 established establish VBN cord-010119-t1x9gknd 2770 8 , , , cord-010119-t1x9gknd 2770 9 and and CC cord-010119-t1x9gknd 2770 10 data datum NNS cord-010119-t1x9gknd 2770 11 on on IN cord-010119-t1x9gknd 2770 12 wastage wastage NN cord-010119-t1x9gknd 2770 13 associated associate VBN cord-010119-t1x9gknd 2770 14 with with IN cord-010119-t1x9gknd 2770 15 MTPs mtp NNS cord-010119-t1x9gknd 2770 16 especially especially RB cord-010119-t1x9gknd 2770 17 sparse sparse JJ cord-010119-t1x9gknd 2770 18 . . . cord-010119-t1x9gknd 2771 1 With with IN cord-010119-t1x9gknd 2771 2 a a DT cord-010119-t1x9gknd 2771 3 redesign redesign NN cord-010119-t1x9gknd 2771 4 of of IN cord-010119-t1x9gknd 2771 5 MTP MTP NNP cord-010119-t1x9gknd 2771 6 and and CC cord-010119-t1x9gknd 2771 7 Obstetric Obstetric NNP cord-010119-t1x9gknd 2771 8 Massive Massive NNP cord-010119-t1x9gknd 2771 9 Transfusion Transfusion NNP cord-010119-t1x9gknd 2771 10 Protocols Protocols NNPS cord-010119-t1x9gknd 2771 11 ( ( -LRB- cord-010119-t1x9gknd 2771 12 OBP obp NN cord-010119-t1x9gknd 2771 13 ) ) -RRB- cord-010119-t1x9gknd 2771 14 which which WDT cord-010119-t1x9gknd 2771 15 have have VBP cord-010119-t1x9gknd 2771 16 different different JJ cord-010119-t1x9gknd 2771 17 blood blood NN cord-010119-t1x9gknd 2771 18 product product NN cord-010119-t1x9gknd 2771 19 preparation preparation NN cord-010119-t1x9gknd 2771 20 schedules schedule NNS cord-010119-t1x9gknd 2771 21 , , , cord-010119-t1x9gknd 2771 22 we -PRON- PRP cord-010119-t1x9gknd 2771 23 assessed assess VBD cord-010119-t1x9gknd 2771 24 wastage wastage NN cord-010119-t1x9gknd 2771 25 , , , cord-010119-t1x9gknd 2771 26 delivery delivery NN cord-010119-t1x9gknd 2771 27 method method NN cord-010119-t1x9gknd 2771 28 , , , cord-010119-t1x9gknd 2771 29 and and CC cord-010119-t1x9gknd 2771 30 product product NN cord-010119-t1x9gknd 2771 31 utilization utilization NN cord-010119-t1x9gknd 2771 32 to to TO cord-010119-t1x9gknd 2771 33 identify identify VB cord-010119-t1x9gknd 2771 34 differences difference NNS cord-010119-t1x9gknd 2771 35 in in IN cord-010119-t1x9gknd 2771 36 wastage wastage NN cord-010119-t1x9gknd 2771 37 during during IN cord-010119-t1x9gknd 2771 38 these these DT cord-010119-t1x9gknd 2771 39 protocols protocol NNS cord-010119-t1x9gknd 2771 40 . . . cord-010119-t1x9gknd 2772 1 Study Study NNP cord-010119-t1x9gknd 2772 2 Design Design NNP cord-010119-t1x9gknd 2772 3 / / SYM cord-010119-t1x9gknd 2772 4 Method method NN cord-010119-t1x9gknd 2772 5 : : : cord-010119-t1x9gknd 2773 1 Following follow VBG cord-010119-t1x9gknd 2773 2 Institutional Institutional NNP cord-010119-t1x9gknd 2773 3 Review Review NNP cord-010119-t1x9gknd 2773 4 Board Board NNP cord-010119-t1x9gknd 2773 5 approval approval NN cord-010119-t1x9gknd 2773 6 , , , cord-010119-t1x9gknd 2773 7 a a DT cord-010119-t1x9gknd 2773 8 retrospective retrospective JJ cord-010119-t1x9gknd 2773 9 study study NN cord-010119-t1x9gknd 2773 10 on on IN cord-010119-t1x9gknd 2773 11 blood blood NN cord-010119-t1x9gknd 2773 12 product product NN cord-010119-t1x9gknd 2773 13 wastage wastage NN cord-010119-t1x9gknd 2773 14 associated associate VBN cord-010119-t1x9gknd 2773 15 with with IN cord-010119-t1x9gknd 2773 16 the the DT cord-010119-t1x9gknd 2773 17 MTP MTP NNP cord-010119-t1x9gknd 2773 18 and and CC cord-010119-t1x9gknd 2773 19 OBP obp NN cord-010119-t1x9gknd 2773 20 between between IN cord-010119-t1x9gknd 2773 21 July July NNP cord-010119-t1x9gknd 2773 22 2015-December 2015-december CD cord-010119-t1x9gknd 2773 23 2016 2016 CD cord-010119-t1x9gknd 2773 24 was be VBD cord-010119-t1x9gknd 2773 25 performed perform VBN cord-010119-t1x9gknd 2773 26 . . . cord-010119-t1x9gknd 2774 1 Data datum NNS cord-010119-t1x9gknd 2774 2 on on IN cord-010119-t1x9gknd 2774 3 numbers number NNS cord-010119-t1x9gknd 2774 4 of of IN cord-010119-t1x9gknd 2774 5 products product NNS cord-010119-t1x9gknd 2774 6 dispensed dispense VBN cord-010119-t1x9gknd 2774 7 and and CC cord-010119-t1x9gknd 2774 8 wasted waste VBN cord-010119-t1x9gknd 2774 9 were be VBD cord-010119-t1x9gknd 2774 10 manually manually RB cord-010119-t1x9gknd 2774 11 collected collect VBN cord-010119-t1x9gknd 2774 12 from from IN cord-010119-t1x9gknd 2774 13 Transfusion Transfusion NNP cord-010119-t1x9gknd 2774 14 Service Service NNP cord-010119-t1x9gknd 2774 15 paper paper NN cord-010119-t1x9gknd 2774 16 and and CC cord-010119-t1x9gknd 2774 17 electronic electronic JJ cord-010119-t1x9gknd 2774 18 records record NNS cord-010119-t1x9gknd 2774 19 and and CC cord-010119-t1x9gknd 2774 20 an an DT cord-010119-t1x9gknd 2774 21 automated automate VBN cord-010119-t1x9gknd 2774 22 data data NN cord-010119-t1x9gknd 2774 23 report report NN cord-010119-t1x9gknd 2774 24 from from IN cord-010119-t1x9gknd 2774 25 the the DT cord-010119-t1x9gknd 2774 26 electronic electronic JJ cord-010119-t1x9gknd 2774 27 medical medical JJ cord-010119-t1x9gknd 2774 28 record record NN cord-010119-t1x9gknd 2774 29 . . . cord-010119-t1x9gknd 2775 1 Results/ Results/ . cord-010119-t1x9gknd 2776 1 Finding find VBG cord-010119-t1x9gknd 2776 2 : : : cord-010119-t1x9gknd 2776 3 The the DT cord-010119-t1x9gknd 2776 4 MTP MTP NNP cord-010119-t1x9gknd 2776 5 resulted result VBD cord-010119-t1x9gknd 2776 6 in in IN cord-010119-t1x9gknd 2776 7 higher high JJR cord-010119-t1x9gknd 2776 8 total total JJ cord-010119-t1x9gknd 2776 9 number number NN cord-010119-t1x9gknd 2776 10 of of IN cord-010119-t1x9gknd 2776 11 wasted waste VBN cord-010119-t1x9gknd 2776 12 products product NNS cord-010119-t1x9gknd 2776 13 than than IN cord-010119-t1x9gknd 2776 14 the the DT cord-010119-t1x9gknd 2776 15 OBP obp NN cord-010119-t1x9gknd 2776 16 ( ( -LRB- cord-010119-t1x9gknd 2776 17 27 27 CD cord-010119-t1x9gknd 2776 18 and and CC cord-010119-t1x9gknd 2776 19 15 15 CD cord-010119-t1x9gknd 2776 20 products product NNS cord-010119-t1x9gknd 2776 21 , , , cord-010119-t1x9gknd 2776 22 respectively respectively RB cord-010119-t1x9gknd 2776 23 ) ) -RRB- cord-010119-t1x9gknd 2777 1 however however RB cord-010119-t1x9gknd 2777 2 , , , cord-010119-t1x9gknd 2777 3 OBP obp NN cord-010119-t1x9gknd 2777 4 wastage wastage NN cord-010119-t1x9gknd 2777 5 occurred occur VBD cord-010119-t1x9gknd 2777 6 more more RBR cord-010119-t1x9gknd 2777 7 frequently frequently RB cord-010119-t1x9gknd 2777 8 in in IN cord-010119-t1x9gknd 2777 9 the the DT cord-010119-t1x9gknd 2777 10 18 18 CD cord-010119-t1x9gknd 2777 11 month month NN cord-010119-t1x9gknd 2777 12 period period NN cord-010119-t1x9gknd 2777 13 . . . cord-010119-t1x9gknd 2778 1 This this DT cord-010119-t1x9gknd 2778 2 reflects reflect VBZ cord-010119-t1x9gknd 2778 3 automatic automatic JJ cord-010119-t1x9gknd 2778 4 thawing thawing NN cord-010119-t1x9gknd 2778 5 of of IN cord-010119-t1x9gknd 2778 6 cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 2778 7 in in IN cord-010119-t1x9gknd 2778 8 the the DT cord-010119-t1x9gknd 2778 9 first first JJ cord-010119-t1x9gknd 2778 10 round round NN cord-010119-t1x9gknd 2778 11 of of IN cord-010119-t1x9gknd 2778 12 deployed deploy VBN cord-010119-t1x9gknd 2778 13 products product NNS cord-010119-t1x9gknd 2778 14 in in IN cord-010119-t1x9gknd 2778 15 the the DT cord-010119-t1x9gknd 2778 16 OPB OPB NNP cord-010119-t1x9gknd 2778 17 . . . cord-010119-t1x9gknd 2779 1 MTP MTP NNP cord-010119-t1x9gknd 2779 2 - - HYPH cord-010119-t1x9gknd 2779 3 trauma trauma NN cord-010119-t1x9gknd 2779 4 activations activation NNS cord-010119-t1x9gknd 2779 5 contributed contribute VBD cord-010119-t1x9gknd 2779 6 higher high JJR cord-010119-t1x9gknd 2779 7 wastage wastage NN cord-010119-t1x9gknd 2779 8 than than IN cord-010119-t1x9gknd 2779 9 non non JJ cord-010119-t1x9gknd 2779 10 - - JJ cord-010119-t1x9gknd 2779 11 trauma trauma JJ cord-010119-t1x9gknd 2779 12 activations activation NNS cord-010119-t1x9gknd 2779 13 ( ( -LRB- cord-010119-t1x9gknd 2779 14 23 23 CD cord-010119-t1x9gknd 2779 15 versus versus IN cord-010119-t1x9gknd 2779 16 4 4 CD cord-010119-t1x9gknd 2779 17 products product NNS cord-010119-t1x9gknd 2779 18 ) ) -RRB- cord-010119-t1x9gknd 2779 19 . . . cord-010119-t1x9gknd 2780 1 This this DT cord-010119-t1x9gknd 2780 2 is be VBZ cord-010119-t1x9gknd 2780 3 skewed skew VBN cord-010119-t1x9gknd 2780 4 by by IN cord-010119-t1x9gknd 2780 5 one one CD cord-010119-t1x9gknd 2780 6 month month NN cord-010119-t1x9gknd 2780 7 when when WRB cord-010119-t1x9gknd 2780 8 20 20 CD cord-010119-t1x9gknd 2780 9 products product NNS cord-010119-t1x9gknd 2780 10 were be VBD cord-010119-t1x9gknd 2780 11 wasted waste VBN cord-010119-t1x9gknd 2780 12 due due IN cord-010119-t1x9gknd 2780 13 to to IN cord-010119-t1x9gknd 2780 14 expiration expiration NN cord-010119-t1x9gknd 2780 15 of of IN cord-010119-t1x9gknd 2780 16 product product NN cord-010119-t1x9gknd 2780 17 on on IN cord-010119-t1x9gknd 2780 18 the the DT cord-010119-t1x9gknd 2780 19 floor floor NN cord-010119-t1x9gknd 2780 20 . . . cord-010119-t1x9gknd 2781 1 Cooler cooler RBR cord-010119-t1x9gknd 2781 2 - - HYPH cord-010119-t1x9gknd 2781 3 related relate VBN cord-010119-t1x9gknd 2781 4 issues issue NNS cord-010119-t1x9gknd 2781 5 ( ( -LRB- cord-010119-t1x9gknd 2781 6 6 6 CD cord-010119-t1x9gknd 2781 7 ) ) -RRB- cord-010119-t1x9gknd 2781 8 and and CC cord-010119-t1x9gknd 2781 9 products product NNS cord-010119-t1x9gknd 2781 10 dwelling dwell VBG cord-010119-t1x9gknd 2781 11 too too RB cord-010119-t1x9gknd 2781 12 long long RB cord-010119-t1x9gknd 2781 13 out out IN cord-010119-t1x9gknd 2781 14 of of IN cord-010119-t1x9gknd 2781 15 a a DT cord-010119-t1x9gknd 2781 16 controlled control VBN cord-010119-t1x9gknd 2781 17 environment environment NN cord-010119-t1x9gknd 2781 18 ( ( -LRB- cord-010119-t1x9gknd 2781 19 5 5 LS cord-010119-t1x9gknd 2781 20 ) ) -RRB- cord-010119-t1x9gknd 2781 21 were be VBD cord-010119-t1x9gknd 2781 22 common common JJ cord-010119-t1x9gknd 2781 23 reasons reason NNS cord-010119-t1x9gknd 2781 24 reported report VBN cord-010119-t1x9gknd 2781 25 for for IN cord-010119-t1x9gknd 2781 26 wastage wastage NN cord-010119-t1x9gknd 2781 27 . . . cord-010119-t1x9gknd 2782 1 The the DT cord-010119-t1x9gknd 2782 2 overall overall JJ cord-010119-t1x9gknd 2782 3 product product NN cord-010119-t1x9gknd 2782 4 wastage wastage NN cord-010119-t1x9gknd 2782 5 rates rate NNS cord-010119-t1x9gknd 2782 6 for for IN cord-010119-t1x9gknd 2782 7 MTP MTP NNP cord-010119-t1x9gknd 2782 8 : : : cord-010119-t1x9gknd 2782 9 trauma trauma NN cord-010119-t1x9gknd 2782 10 , , , cord-010119-t1x9gknd 2782 11 MTP MTP NNP cord-010119-t1x9gknd 2782 12 : : : cord-010119-t1x9gknd 2782 13 nontrauma nontrauma NNP cord-010119-t1x9gknd 2782 14 , , , cord-010119-t1x9gknd 2782 15 and and CC cord-010119-t1x9gknd 2782 16 OBP OBP NNP cord-010119-t1x9gknd 2782 17 were be VBD cord-010119-t1x9gknd 2782 18 1.7 1.7 CD cord-010119-t1x9gknd 2782 19 % % NN cord-010119-t1x9gknd 2782 20 , , , cord-010119-t1x9gknd 2782 21 0.3 0.3 CD cord-010119-t1x9gknd 2782 22 % % NN cord-010119-t1x9gknd 2782 23 , , , cord-010119-t1x9gknd 2782 24 and and CC cord-010119-t1x9gknd 2782 25 2.3 2.3 CD cord-010119-t1x9gknd 2782 26 % % NN cord-010119-t1x9gknd 2782 27 , , , cord-010119-t1x9gknd 2782 28 respectively respectively RB cord-010119-t1x9gknd 2782 29 , , , cord-010119-t1x9gknd 2782 30 with with IN cord-010119-t1x9gknd 2782 31 a a DT cord-010119-t1x9gknd 2782 32 total total JJ cord-010119-t1x9gknd 2782 33 exsanguination exsanguination NN cord-010119-t1x9gknd 2782 34 protocol protocol NN cord-010119-t1x9gknd 2782 35 waste waste NN cord-010119-t1x9gknd 2782 36 rate rate NN cord-010119-t1x9gknd 2782 37 of of IN cord-010119-t1x9gknd 2782 38 1.33 1.33 CD cord-010119-t1x9gknd 2782 39 % % NN cord-010119-t1x9gknd 2782 40 . . . cord-010119-t1x9gknd 2783 1 The the DT cord-010119-t1x9gknd 2783 2 difference difference NN cord-010119-t1x9gknd 2783 3 between between IN cord-010119-t1x9gknd 2783 4 the the DT cord-010119-t1x9gknd 2783 5 overall overall JJ cord-010119-t1x9gknd 2783 6 proportion proportion NN cord-010119-t1x9gknd 2783 7 of of IN cord-010119-t1x9gknd 2783 8 waste waste NN cord-010119-t1x9gknd 2783 9 between between IN cord-010119-t1x9gknd 2783 10 the the DT cord-010119-t1x9gknd 2783 11 MTP MTP NNP cord-010119-t1x9gknd 2783 12 and and CC cord-010119-t1x9gknd 2783 13 OBP OBP NNP cord-010119-t1x9gknd 2783 14 protocols protocol NNS cord-010119-t1x9gknd 2783 15 was be VBD cord-010119-t1x9gknd 2783 16 insignificant insignificant JJ cord-010119-t1x9gknd 2783 17 ( ( -LRB- cord-010119-t1x9gknd 2783 18 p50.176 p50.176 NN cord-010119-t1x9gknd 2783 19 ) ) -RRB- cord-010119-t1x9gknd 2783 20 . . . cord-010119-t1x9gknd 2784 1 Conclusion conclusion NN cord-010119-t1x9gknd 2784 2 : : : cord-010119-t1x9gknd 2784 3 Wastage wastage NN cord-010119-t1x9gknd 2784 4 associated associate VBN cord-010119-t1x9gknd 2784 5 with with IN cord-010119-t1x9gknd 2784 6 both both DT cord-010119-t1x9gknd 2784 7 protocols protocol NNS cord-010119-t1x9gknd 2784 8 was be VBD cord-010119-t1x9gknd 2784 9 low low JJ cord-010119-t1x9gknd 2784 10 and and CC cord-010119-t1x9gknd 2784 11 there there EX cord-010119-t1x9gknd 2784 12 is be VBZ cord-010119-t1x9gknd 2784 13 no no DT cord-010119-t1x9gknd 2784 14 statistical statistical JJ cord-010119-t1x9gknd 2784 15 difference difference NN cord-010119-t1x9gknd 2784 16 between between IN cord-010119-t1x9gknd 2784 17 MTP MTP NNP cord-010119-t1x9gknd 2784 18 versus versus IN cord-010119-t1x9gknd 2784 19 OBP obp NN cord-010119-t1x9gknd 2784 20 wastage wastage NN cord-010119-t1x9gknd 2784 21 . . . cord-010119-t1x9gknd 2785 1 Coolerrelated Coolerrelated NNP cord-010119-t1x9gknd 2785 2 issues issue NNS cord-010119-t1x9gknd 2785 3 accounted account VBD cord-010119-t1x9gknd 2785 4 for for IN cord-010119-t1x9gknd 2785 5 most most JJS cord-010119-t1x9gknd 2785 6 product product NN cord-010119-t1x9gknd 2785 7 wastage wastage NN cord-010119-t1x9gknd 2785 8 , , , cord-010119-t1x9gknd 2785 9 allowing allow VBG cord-010119-t1x9gknd 2785 10 for for IN cord-010119-t1x9gknd 2785 11 targeted targeted JJ cord-010119-t1x9gknd 2785 12 waste waste NN cord-010119-t1x9gknd 2785 13 reduction reduction NN cord-010119-t1x9gknd 2785 14 strategies strategy NNS cord-010119-t1x9gknd 2785 15 including include VBG cord-010119-t1x9gknd 2785 16 educational educational JJ cord-010119-t1x9gknd 2785 17 outreach outreach NN cord-010119-t1x9gknd 2785 18 and and CC cord-010119-t1x9gknd 2785 19 improved improved JJ cord-010119-t1x9gknd 2785 20 product product NN cord-010119-t1x9gknd 2785 21 delivery delivery NN cord-010119-t1x9gknd 2785 22 methods method NNS cord-010119-t1x9gknd 2785 23 . . . cord-010119-t1x9gknd 2786 1 Better well JJR cord-010119-t1x9gknd 2786 2 documentation documentation NN cord-010119-t1x9gknd 2786 3 of of IN cord-010119-t1x9gknd 2786 4 waste waste NN cord-010119-t1x9gknd 2786 5 events event NNS cord-010119-t1x9gknd 2786 6 identifies identify VBZ cord-010119-t1x9gknd 2786 7 wastage wastage NN cord-010119-t1x9gknd 2786 8 trends trend NNS cord-010119-t1x9gknd 2786 9 for for IN cord-010119-t1x9gknd 2786 10 further further JJ cord-010119-t1x9gknd 2786 11 product product NN cord-010119-t1x9gknd 2786 12 utilization utilization NN cord-010119-t1x9gknd 2786 13 optimization optimization NN cord-010119-t1x9gknd 2786 14 during during IN cord-010119-t1x9gknd 2786 15 these these DT cord-010119-t1x9gknd 2786 16 protocols protocol NNS cord-010119-t1x9gknd 2786 17 . . . cord-010119-t1x9gknd 2787 1 A a DT cord-010119-t1x9gknd 2787 2 17 17 CD cord-010119-t1x9gknd 2787 3 year year NN cord-010119-t1x9gknd 2787 4 old old JJ cord-010119-t1x9gknd 2787 5 female female NN cord-010119-t1x9gknd 2787 6 with with IN cord-010119-t1x9gknd 2787 7 multiple multiple JJ cord-010119-t1x9gknd 2787 8 gun gun NN cord-010119-t1x9gknd 2787 9 shots shot NNS cord-010119-t1x9gknd 2787 10 was be VBD cord-010119-t1x9gknd 2787 11 admitted admit VBN cord-010119-t1x9gknd 2787 12 to to IN cord-010119-t1x9gknd 2787 13 a a DT cord-010119-t1x9gknd 2787 14 level level JJ cord-010119-t1x9gknd 2787 15 one one CD cord-010119-t1x9gknd 2787 16 trauma trauma NN cord-010119-t1x9gknd 2787 17 center center NN cord-010119-t1x9gknd 2787 18 and and CC cord-010119-t1x9gknd 2787 19 received receive VBD cord-010119-t1x9gknd 2787 20 uncrossmatched uncrossmatched JJ cord-010119-t1x9gknd 2787 21 group group NN cord-010119-t1x9gknd 2787 22 O O NNP cord-010119-t1x9gknd 2787 23 , , , cord-010119-t1x9gknd 2787 24 Rh Rh NNP cord-010119-t1x9gknd 2787 25 negative negative JJ cord-010119-t1x9gknd 2787 26 ( ( -LRB- cord-010119-t1x9gknd 2787 27 D- d- NN cord-010119-t1x9gknd 2787 28 ) ) -RRB- cord-010119-t1x9gknd 2787 29 red red JJ cord-010119-t1x9gknd 2787 30 blood blood NN cord-010119-t1x9gknd 2787 31 cells cell NNS cord-010119-t1x9gknd 2787 32 ( ( -LRB- cord-010119-t1x9gknd 2787 33 RBCs rbc NNS cord-010119-t1x9gknd 2787 34 ) ) -RRB- cord-010119-t1x9gknd 2787 35 through through IN cord-010119-t1x9gknd 2787 36 a a DT cord-010119-t1x9gknd 2787 37 rapid rapid JJ cord-010119-t1x9gknd 2787 38 infuser infuser NN cord-010119-t1x9gknd 2787 39 during during IN cord-010119-t1x9gknd 2787 40 resuscitation resuscitation NN cord-010119-t1x9gknd 2787 41 . . . cord-010119-t1x9gknd 2788 1 Transfusion transfusion NN cord-010119-t1x9gknd 2788 2 of of IN cord-010119-t1x9gknd 2788 3 uncrossmatched uncrossmatched JJ cord-010119-t1x9gknd 2788 4 products product NNS cord-010119-t1x9gknd 2788 5 before before IN cord-010119-t1x9gknd 2788 6 sample sample NN cord-010119-t1x9gknd 2788 7 collection collection NN cord-010119-t1x9gknd 2788 8 can can MD cord-010119-t1x9gknd 2788 9 lead lead VB cord-010119-t1x9gknd 2788 10 to to IN cord-010119-t1x9gknd 2788 11 errors error NNS cord-010119-t1x9gknd 2788 12 and and CC cord-010119-t1x9gknd 2788 13 confusion confusion NN cord-010119-t1x9gknd 2788 14 in in IN cord-010119-t1x9gknd 2788 15 blood blood NN cord-010119-t1x9gknd 2788 16 typing typing NN cord-010119-t1x9gknd 2788 17 , , , cord-010119-t1x9gknd 2788 18 as as IN cord-010119-t1x9gknd 2788 19 can can MD cord-010119-t1x9gknd 2788 20 the the DT cord-010119-t1x9gknd 2788 21 venipuncture venipuncture NN cord-010119-t1x9gknd 2788 22 site site NN cord-010119-t1x9gknd 2788 23 used use VBN cord-010119-t1x9gknd 2788 24 for for IN cord-010119-t1x9gknd 2788 25 collecting collect VBG cord-010119-t1x9gknd 2788 26 the the DT cord-010119-t1x9gknd 2788 27 patient patient NN cord-010119-t1x9gknd 2788 28 's 's POS cord-010119-t1x9gknd 2788 29 blood blood NN cord-010119-t1x9gknd 2788 30 sample sample NN cord-010119-t1x9gknd 2788 31 . . . cord-010119-t1x9gknd 2789 1 The the DT cord-010119-t1x9gknd 2789 2 current current JJ cord-010119-t1x9gknd 2789 3 FDA FDA NNP cord-010119-t1x9gknd 2789 4 guidance guidance NN cord-010119-t1x9gknd 2789 5 and and CC cord-010119-t1x9gknd 2789 6 AABB AABB NNP cord-010119-t1x9gknd 2789 7 standard standard NN cord-010119-t1x9gknd 2789 8 of of IN cord-010119-t1x9gknd 2789 9 two two CD cord-010119-t1x9gknd 2789 10 samples sample NNS cord-010119-t1x9gknd 2789 11 for for IN cord-010119-t1x9gknd 2789 12 determination determination NN cord-010119-t1x9gknd 2789 13 of of IN cord-010119-t1x9gknd 2789 14 blood blood NN cord-010119-t1x9gknd 2789 15 type type NN cord-010119-t1x9gknd 2789 16 to to TO cord-010119-t1x9gknd 2789 17 prevent prevent VB cord-010119-t1x9gknd 2789 18 cases case NNS cord-010119-t1x9gknd 2790 1 Wrong wrong JJ cord-010119-t1x9gknd 2790 2 Blood blood NN cord-010119-t1x9gknd 2790 3 in in IN cord-010119-t1x9gknd 2790 4 Tube tube NN cord-010119-t1x9gknd 2790 5 ( ( -LRB- cord-010119-t1x9gknd 2790 6 WBIT WBIT NNP cord-010119-t1x9gknd 2790 7 ) ) -RRB- cord-010119-t1x9gknd 2790 8 or or CC cord-010119-t1x9gknd 2790 9 electronic electronic JJ cord-010119-t1x9gknd 2790 10 identification identification NN cord-010119-t1x9gknd 2790 11 systems system NNS cord-010119-t1x9gknd 2790 12 do do VBP cord-010119-t1x9gknd 2790 13 not not RB cord-010119-t1x9gknd 2790 14 always always RB cord-010119-t1x9gknd 2790 15 catch catch VB cord-010119-t1x9gknd 2790 16 or or CC cord-010119-t1x9gknd 2790 17 clarify clarify VB cord-010119-t1x9gknd 2790 18 these these DT cord-010119-t1x9gknd 2790 19 errors error NNS cord-010119-t1x9gknd 2790 20 . . . cord-010119-t1x9gknd 2791 1 Study Study NNP cord-010119-t1x9gknd 2791 2 Design Design NNP cord-010119-t1x9gknd 2791 3 / / SYM cord-010119-t1x9gknd 2791 4 Methods method NNS cord-010119-t1x9gknd 2791 5 : : : cord-010119-t1x9gknd 2791 6 Patient Patient NNP cord-010119-t1x9gknd 2791 7 was be VBD cord-010119-t1x9gknd 2791 8 tested test VBN cord-010119-t1x9gknd 2791 9 by by IN cord-010119-t1x9gknd 2791 10 manual manual JJ cord-010119-t1x9gknd 2791 11 tube tube NN cord-010119-t1x9gknd 2791 12 method method NN cord-010119-t1x9gknd 2791 13 . . . cord-010119-t1x9gknd 2792 1 Two two CD cord-010119-t1x9gknd 2792 2 different different JJ cord-010119-t1x9gknd 2792 3 technologists technologist NNS cord-010119-t1x9gknd 2792 4 using use VBG cord-010119-t1x9gknd 2792 5 two two CD cord-010119-t1x9gknd 2792 6 different different JJ cord-010119-t1x9gknd 2792 7 reagent reagent NN cord-010119-t1x9gknd 2792 8 racks rack NNS cord-010119-t1x9gknd 2792 9 performed perform VBD cord-010119-t1x9gknd 2792 10 initial initial JJ cord-010119-t1x9gknd 2792 11 testing testing NN cord-010119-t1x9gknd 2792 12 with with IN cord-010119-t1x9gknd 2792 13 matching match VBG cord-010119-t1x9gknd 2792 14 results result NNS cord-010119-t1x9gknd 2792 15 . . . cord-010119-t1x9gknd 2793 1 Results result NNS cord-010119-t1x9gknd 2793 2 / / SYM cord-010119-t1x9gknd 2793 3 Findings finding NNS cord-010119-t1x9gknd 2793 4 : : : cord-010119-t1x9gknd 2794 1 Two two CD cord-010119-t1x9gknd 2794 2 samples sample NNS cord-010119-t1x9gknd 2794 3 were be VBD cord-010119-t1x9gknd 2794 4 collected collect VBN cord-010119-t1x9gknd 2794 5 during during IN cord-010119-t1x9gknd 2794 6 resuscitation resuscitation NN cord-010119-t1x9gknd 2794 7 from from IN cord-010119-t1x9gknd 2794 8 the the DT cord-010119-t1x9gknd 2794 9 patient patient NN cord-010119-t1x9gknd 2794 10 and and CC cord-010119-t1x9gknd 2794 11 typed type VBN cord-010119-t1x9gknd 2794 12 as as IN cord-010119-t1x9gknd 2794 13 O O NNP cord-010119-t1x9gknd 2794 14 D- d- NN cord-010119-t1x9gknd 2794 15 . . . cord-010119-t1x9gknd 2795 1 Patient Patient NNP cord-010119-t1x9gknd 2795 2 was be VBD cord-010119-t1x9gknd 2795 3 transfused transfuse VBN cord-010119-t1x9gknd 2795 4 with with IN cord-010119-t1x9gknd 2795 5 5 5 CD cord-010119-t1x9gknd 2795 6 units unit NNS cord-010119-t1x9gknd 2795 7 of of IN cord-010119-t1x9gknd 2795 8 O o NN cord-010119-t1x9gknd 2795 9 D d NN cord-010119-t1x9gknd 2795 10 - - HYPH cord-010119-t1x9gknd 2795 11 RBCs rbc NNS cord-010119-t1x9gknd 2795 12 before before IN cord-010119-t1x9gknd 2795 13 stabilizing stabilize VBG cord-010119-t1x9gknd 2795 14 . . . cord-010119-t1x9gknd 2796 1 Two two CD cord-010119-t1x9gknd 2796 2 days day NNS cord-010119-t1x9gknd 2796 3 later later RB cord-010119-t1x9gknd 2796 4 another another DT cord-010119-t1x9gknd 2796 5 sample sample NN cord-010119-t1x9gknd 2796 6 was be VBD cord-010119-t1x9gknd 2796 7 collected collect VBN cord-010119-t1x9gknd 2796 8 and and CC cord-010119-t1x9gknd 2796 9 typed type VBN cord-010119-t1x9gknd 2796 10 as as IN cord-010119-t1x9gknd 2796 11 O O NNP cord-010119-t1x9gknd 2796 12 Rh Rh NNP cord-010119-t1x9gknd 2796 13 positive positive JJ cord-010119-t1x9gknd 2796 14 ( ( -LRB- cord-010119-t1x9gknd 2796 15 D1 d1 NN cord-010119-t1x9gknd 2796 16 ) ) -RRB- cord-010119-t1x9gknd 2796 17 with with IN cord-010119-t1x9gknd 2796 18 mixed mixed JJ cord-010119-t1x9gknd 2796 19 field field NN cord-010119-t1x9gknd 2796 20 being be VBG cord-010119-t1x9gknd 2796 21 seen see VBN cord-010119-t1x9gknd 2796 22 on on IN cord-010119-t1x9gknd 2796 23 the the DT cord-010119-t1x9gknd 2796 24 anti anti JJ cord-010119-t1x9gknd 2796 25 - - NNP cord-010119-t1x9gknd 2796 26 D. D. NNP cord-010119-t1x9gknd 2797 1 A a DT cord-010119-t1x9gknd 2797 2 weak weak JJ cord-010119-t1x9gknd 2797 3 D d NN cord-010119-t1x9gknd 2797 4 testing testing NN cord-010119-t1x9gknd 2797 5 was be VBD cord-010119-t1x9gknd 2797 6 performed perform VBN cord-010119-t1x9gknd 2797 7 to to TO cord-010119-t1x9gknd 2797 8 see see VB cord-010119-t1x9gknd 2797 9 if if IN cord-010119-t1x9gknd 2797 10 the the DT cord-010119-t1x9gknd 2797 11 negative negative JJ cord-010119-t1x9gknd 2797 12 result result NN cord-010119-t1x9gknd 2797 13 with with IN cord-010119-t1x9gknd 2797 14 anti anti JJ cord-010119-t1x9gknd 2797 15 - - JJ cord-010119-t1x9gknd 2797 16 D d JJ cord-010119-t1x9gknd 2797 17 could could MD cord-010119-t1x9gknd 2797 18 be be VB cord-010119-t1x9gknd 2797 19 strengthened strengthen VBN cord-010119-t1x9gknd 2797 20 through through IN cord-010119-t1x9gknd 2797 21 incubation incubation NN cord-010119-t1x9gknd 2797 22 . . . cord-010119-t1x9gknd 2798 1 Both both DT cord-010119-t1x9gknd 2798 2 original original JJ cord-010119-t1x9gknd 2798 3 samples sample NNS cord-010119-t1x9gknd 2798 4 still still RB cord-010119-t1x9gknd 2798 5 resulted result VBD cord-010119-t1x9gknd 2798 6 as as IN cord-010119-t1x9gknd 2798 7 D- D- NNP cord-010119-t1x9gknd 2798 8 ( ( -LRB- cord-010119-t1x9gknd 2798 9 table table NN cord-010119-t1x9gknd 2798 10 A a NN cord-010119-t1x9gknd 2798 11 ) ) -RRB- cord-010119-t1x9gknd 2798 12 . . . cord-010119-t1x9gknd 2799 1 After after IN cord-010119-t1x9gknd 2799 2 consulting consult VBG cord-010119-t1x9gknd 2799 3 the the DT cord-010119-t1x9gknd 2799 4 patient patient NN cord-010119-t1x9gknd 2799 5 care care NN cord-010119-t1x9gknd 2799 6 team team NN cord-010119-t1x9gknd 2799 7 it -PRON- PRP cord-010119-t1x9gknd 2799 8 was be VBD cord-010119-t1x9gknd 2799 9 discovered discover VBN cord-010119-t1x9gknd 2799 10 the the DT cord-010119-t1x9gknd 2799 11 samples sample NNS cord-010119-t1x9gknd 2799 12 were be VBD cord-010119-t1x9gknd 2799 13 collected collect VBN cord-010119-t1x9gknd 2799 14 above above IN cord-010119-t1x9gknd 2799 15 the the DT cord-010119-t1x9gknd 2799 16 IV IV NNP cord-010119-t1x9gknd 2799 17 site site NN cord-010119-t1x9gknd 2799 18 after after IN cord-010119-t1x9gknd 2799 19 one one CD cord-010119-t1x9gknd 2799 20 unit unit NN cord-010119-t1x9gknd 2799 21 had have VBD cord-010119-t1x9gknd 2799 22 been be VBN cord-010119-t1x9gknd 2799 23 completed complete VBN cord-010119-t1x9gknd 2799 24 and and CC cord-010119-t1x9gknd 2799 25 while while IN cord-010119-t1x9gknd 2799 26 the the DT cord-010119-t1x9gknd 2799 27 second second JJ cord-010119-t1x9gknd 2799 28 unit unit NN cord-010119-t1x9gknd 2799 29 was be VBD cord-010119-t1x9gknd 2799 30 being be VBG cord-010119-t1x9gknd 2799 31 transfused transfuse VBN cord-010119-t1x9gknd 2799 32 . . . cord-010119-t1x9gknd 2800 1 It -PRON- PRP cord-010119-t1x9gknd 2800 2 was be VBD cord-010119-t1x9gknd 2800 3 also also RB cord-010119-t1x9gknd 2800 4 discovered discover VBN cord-010119-t1x9gknd 2800 5 all all DT cord-010119-t1x9gknd 2800 6 other other JJ cord-010119-t1x9gknd 2800 7 clinical clinical JJ cord-010119-t1x9gknd 2800 8 laboratory laboratory NN cord-010119-t1x9gknd 2800 9 samples sample NNS cord-010119-t1x9gknd 2800 10 were be VBD cord-010119-t1x9gknd 2800 11 rejected reject VBN cord-010119-t1x9gknd 2800 12 due due IN cord-010119-t1x9gknd 2800 13 to to IN cord-010119-t1x9gknd 2800 14 possible possible JJ cord-010119-t1x9gknd 2800 15 line line NN cord-010119-t1x9gknd 2800 16 contamination contamination NN cord-010119-t1x9gknd 2800 17 when when WRB cord-010119-t1x9gknd 2800 18 results result NNS cord-010119-t1x9gknd 2800 19 for for IN cord-010119-t1x9gknd 2800 20 the the DT cord-010119-t1x9gknd 2800 21 sodium sodium NN cord-010119-t1x9gknd 2800 22 , , , cord-010119-t1x9gknd 2800 23 potassium potassium NN cord-010119-t1x9gknd 2800 24 , , , cord-010119-t1x9gknd 2800 25 and and CC cord-010119-t1x9gknd 2800 26 glucose glucose NN cord-010119-t1x9gknd 2800 27 appeared appear VBD cord-010119-t1x9gknd 2800 28 inaccurate inaccurate JJ cord-010119-t1x9gknd 2800 29 . . . cord-010119-t1x9gknd 2801 1 The the DT cord-010119-t1x9gknd 2801 2 transfusion transfusion NN cord-010119-t1x9gknd 2801 3 service service NN cord-010119-t1x9gknd 2801 4 laboratory laboratory NN cord-010119-t1x9gknd 2801 5 is be VBZ cord-010119-t1x9gknd 2801 6 in in IN cord-010119-t1x9gknd 2801 7 a a DT cord-010119-t1x9gknd 2801 8 different different JJ cord-010119-t1x9gknd 2801 9 area area NN cord-010119-t1x9gknd 2801 10 of of IN cord-010119-t1x9gknd 2801 11 the the DT cord-010119-t1x9gknd 2801 12 hospital hospital NN cord-010119-t1x9gknd 2801 13 and and CC cord-010119-t1x9gknd 2801 14 was be VBD cord-010119-t1x9gknd 2801 15 unaware unaware JJ cord-010119-t1x9gknd 2801 16 those those DT cord-010119-t1x9gknd 2801 17 samples sample NNS cord-010119-t1x9gknd 2801 18 had have VBD cord-010119-t1x9gknd 2801 19 been be VBN cord-010119-t1x9gknd 2801 20 rejected reject VBN cord-010119-t1x9gknd 2801 21 . . . cord-010119-t1x9gknd 2802 1 Conclusion conclusion NN cord-010119-t1x9gknd 2802 2 : : : cord-010119-t1x9gknd 2803 1 The the DT cord-010119-t1x9gknd 2803 2 initial initial JJ cord-010119-t1x9gknd 2803 3 samples sample NNS cord-010119-t1x9gknd 2803 4 were be VBD cord-010119-t1x9gknd 2803 5 collected collect VBN cord-010119-t1x9gknd 2803 6 above above IN cord-010119-t1x9gknd 2803 7 the the DT cord-010119-t1x9gknd 2803 8 IV IV NNP cord-010119-t1x9gknd 2803 9 site site NN cord-010119-t1x9gknd 2803 10 and and CC cord-010119-t1x9gknd 2803 11 were be VBD cord-010119-t1x9gknd 2803 12 contaminated contaminate VBN cord-010119-t1x9gknd 2803 13 with with IN cord-010119-t1x9gknd 2803 14 the the DT cord-010119-t1x9gknd 2803 15 D d NN cord-010119-t1x9gknd 2803 16 - - HYPH cord-010119-t1x9gknd 2803 17 blood blood NN cord-010119-t1x9gknd 2803 18 product product NN cord-010119-t1x9gknd 2803 19 being be VBG cord-010119-t1x9gknd 2803 20 rapidly rapidly RB cord-010119-t1x9gknd 2803 21 transfused transfuse VBN cord-010119-t1x9gknd 2803 22 during during IN cord-010119-t1x9gknd 2803 23 resuscitation resuscitation NN cord-010119-t1x9gknd 2803 24 . . . cord-010119-t1x9gknd 2804 1 The the DT cord-010119-t1x9gknd 2804 2 samples sample NNS cord-010119-t1x9gknd 2804 3 collected collect VBN cord-010119-t1x9gknd 2804 4 during during IN cord-010119-t1x9gknd 2804 5 the the DT cord-010119-t1x9gknd 2804 6 initial initial JJ cord-010119-t1x9gknd 2804 7 trauma trauma NN cord-010119-t1x9gknd 2804 8 response response NN cord-010119-t1x9gknd 2804 9 should should MD cord-010119-t1x9gknd 2804 10 have have VB cord-010119-t1x9gknd 2804 11 been be VBN cord-010119-t1x9gknd 2804 12 rejected reject VBN cord-010119-t1x9gknd 2804 13 and and CC cord-010119-t1x9gknd 2804 14 a a DT cord-010119-t1x9gknd 2804 15 request request NN cord-010119-t1x9gknd 2804 16 made make VBN cord-010119-t1x9gknd 2804 17 for for IN cord-010119-t1x9gknd 2804 18 samples sample NNS cord-010119-t1x9gknd 2804 19 drawn draw VBN cord-010119-t1x9gknd 2804 20 below below IN cord-010119-t1x9gknd 2804 21 the the DT cord-010119-t1x9gknd 2804 22 IV IV NNP cord-010119-t1x9gknd 2804 23 site site NN cord-010119-t1x9gknd 2804 24 . . . cord-010119-t1x9gknd 2805 1 Because because IN cord-010119-t1x9gknd 2805 2 both both DT cord-010119-t1x9gknd 2805 3 samples sample NNS cord-010119-t1x9gknd 2805 4 were be VBD cord-010119-t1x9gknd 2805 5 collected collect VBN cord-010119-t1x9gknd 2805 6 while while IN cord-010119-t1x9gknd 2805 7 the the DT cord-010119-t1x9gknd 2805 8 unit unit NN cord-010119-t1x9gknd 2805 9 was be VBD cord-010119-t1x9gknd 2805 10 being be VBG cord-010119-t1x9gknd 2805 11 transfused transfuse VBN cord-010119-t1x9gknd 2805 12 , , , cord-010119-t1x9gknd 2805 13 contamination contamination NN cord-010119-t1x9gknd 2805 14 was be VBD cord-010119-t1x9gknd 2805 15 in in IN cord-010119-t1x9gknd 2805 16 both both DT cord-010119-t1x9gknd 2805 17 . . . cord-010119-t1x9gknd 2806 1 Use use NN cord-010119-t1x9gknd 2806 2 of of IN cord-010119-t1x9gknd 2806 3 a a DT cord-010119-t1x9gknd 2806 4 handheld handheld JJ cord-010119-t1x9gknd 2806 5 barcode barcode NN cord-010119-t1x9gknd 2806 6 system system NN cord-010119-t1x9gknd 2806 7 would would MD cord-010119-t1x9gknd 2806 8 not not RB cord-010119-t1x9gknd 2806 9 have have VB cord-010119-t1x9gknd 2806 10 caught catch VBN cord-010119-t1x9gknd 2806 11 this this DT cord-010119-t1x9gknd 2806 12 error error NN cord-010119-t1x9gknd 2806 13 because because IN cord-010119-t1x9gknd 2806 14 the the DT cord-010119-t1x9gknd 2806 15 patient patient NN cord-010119-t1x9gknd 2806 16 had have VBD cord-010119-t1x9gknd 2806 17 been be VBN cord-010119-t1x9gknd 2806 18 correctly correctly RB cord-010119-t1x9gknd 2806 19 identified identify VBN cord-010119-t1x9gknd 2806 20 . . . cord-010119-t1x9gknd 2807 1 Future future JJ cord-010119-t1x9gknd 2807 2 prevention prevention NN cord-010119-t1x9gknd 2807 3 of of IN cord-010119-t1x9gknd 2807 4 the the DT cord-010119-t1x9gknd 2807 5 above above JJ cord-010119-t1x9gknd 2807 6 anomaly anomaly NN cord-010119-t1x9gknd 2807 7 would would MD cord-010119-t1x9gknd 2807 8 be be VB cord-010119-t1x9gknd 2807 9 the the DT cord-010119-t1x9gknd 2807 10 education education NN cord-010119-t1x9gknd 2807 11 of of IN cord-010119-t1x9gknd 2807 12 transfusion transfusion NN cord-010119-t1x9gknd 2807 13 testing testing NN cord-010119-t1x9gknd 2807 14 staff staff NN cord-010119-t1x9gknd 2807 15 to to TO cord-010119-t1x9gknd 2807 16 recognize recognize VB cord-010119-t1x9gknd 2807 17 an an DT cord-010119-t1x9gknd 2807 18 abnormal abnormal JJ cord-010119-t1x9gknd 2807 19 high high JJ cord-010119-t1x9gknd 2807 20 hematocrit hematocrit NN cord-010119-t1x9gknd 2807 21 : : : cord-010119-t1x9gknd 2807 22 secondly secondly RB cord-010119-t1x9gknd 2807 23 reminding remind VBG cord-010119-t1x9gknd 2807 24 the the DT cord-010119-t1x9gknd 2807 25 staff staff NN cord-010119-t1x9gknd 2807 26 collecting collect VBG cord-010119-t1x9gknd 2807 27 samples sample NNS cord-010119-t1x9gknd 2807 28 to to TO cord-010119-t1x9gknd 2807 29 be be VB cord-010119-t1x9gknd 2807 30 aware aware JJ cord-010119-t1x9gknd 2807 31 of of IN cord-010119-t1x9gknd 2807 32 the the DT cord-010119-t1x9gknd 2807 33 proper proper JJ cord-010119-t1x9gknd 2807 34 collection collection NN cord-010119-t1x9gknd 2807 35 procedures procedure NNS cord-010119-t1x9gknd 2807 36 for for IN cord-010119-t1x9gknd 2807 37 laboratory laboratory NN cord-010119-t1x9gknd 2807 38 testing testing NN cord-010119-t1x9gknd 2807 39 , , , cord-010119-t1x9gknd 2807 40 which which WDT cord-010119-t1x9gknd 2807 41 would would MD cord-010119-t1x9gknd 2807 42 include include VB cord-010119-t1x9gknd 2807 43 type type NN cord-010119-t1x9gknd 2807 44 and and CC cord-010119-t1x9gknd 2807 45 screen screen NN cord-010119-t1x9gknd 2807 46 . . . cord-010119-t1x9gknd 2808 1 Facilities facility NNS cord-010119-t1x9gknd 2808 2 also also RB cord-010119-t1x9gknd 2808 3 should should MD cord-010119-t1x9gknd 2808 4 strive strive VB cord-010119-t1x9gknd 2808 5 to to TO cord-010119-t1x9gknd 2808 6 perform perform VB cord-010119-t1x9gknd 2808 7 collection collection NN cord-010119-t1x9gknd 2808 8 of of IN cord-010119-t1x9gknd 2808 9 the the DT cord-010119-t1x9gknd 2808 10 confirmatory confirmatory JJ cord-010119-t1x9gknd 2808 11 sample sample NN cord-010119-t1x9gknd 2808 12 from from IN cord-010119-t1x9gknd 2808 13 a a DT cord-010119-t1x9gknd 2808 14 completely completely RB cord-010119-t1x9gknd 2808 15 different different JJ cord-010119-t1x9gknd 2808 16 venipuncture venipuncture NN cord-010119-t1x9gknd 2808 17 site site NN cord-010119-t1x9gknd 2808 18 . . . cord-010119-t1x9gknd 2809 1 Impact impact NN cord-010119-t1x9gknd 2809 2 of of IN cord-010119-t1x9gknd 2809 3 Cell Cell NNP cord-010119-t1x9gknd 2809 4 Saver Saver NNP cord-010119-t1x9gknd 2809 5 Usage Usage NNP cord-010119-t1x9gknd 2809 6 during during IN cord-010119-t1x9gknd 2809 7 Solid Solid NNP cord-010119-t1x9gknd 2809 8 Organ Organ NNP cord-010119-t1x9gknd 2809 9 Transplants Transplants NNPS cord-010119-t1x9gknd 2809 10 at at IN cord-010119-t1x9gknd 2809 11 a a DT cord-010119-t1x9gknd 2809 12 Major Major NNP cord-010119-t1x9gknd 2809 13 Institution Institution NNP cord-010119-t1x9gknd 2809 14 Holly Holly NNP cord-010119-t1x9gknd 2809 15 Ross Ross NNP cord-010119-t1x9gknd 2810 1 * * NFP cord-010119-t1x9gknd 2810 2 1 1 CD cord-010119-t1x9gknd 2810 3 , , , cord-010119-t1x9gknd 2810 4 Edward Edward NNP cord-010119-t1x9gknd 2810 5 Smith Smith NNP cord-010119-t1x9gknd 2810 6 2 2 CD cord-010119-t1x9gknd 2810 7 , , , cord-010119-t1x9gknd 2810 8 Thomas Thomas NNP cord-010119-t1x9gknd 2810 9 Brown Brown NNP cord-010119-t1x9gknd 2810 10 2 2 CD cord-010119-t1x9gknd 2810 11 , , , cord-010119-t1x9gknd 2810 12 Foeks Foeks NNP cord-010119-t1x9gknd 2810 13 Jeremy Jeremy NNP cord-010119-t1x9gknd 2810 14 2 2 CD cord-010119-t1x9gknd 2810 15 , , , cord-010119-t1x9gknd 2810 16 Metcalf Metcalf NNP cord-010119-t1x9gknd 2810 17 Suzanne Suzanne NNP cord-010119-t1x9gknd 2810 18 2 2 CD cord-010119-t1x9gknd 2810 19 , , , cord-010119-t1x9gknd 2810 20 James James NNP cord-010119-t1x9gknd 2810 21 Johnson Johnson NNP cord-010119-t1x9gknd 2810 22 2 2 CD cord-010119-t1x9gknd 2810 23 , , , cord-010119-t1x9gknd 2810 24 Peter Peter NNP cord-010119-t1x9gknd 2810 25 Davis Davis NNP cord-010119-t1x9gknd 2810 26 2 2 CD cord-010119-t1x9gknd 2810 27 , , , cord-010119-t1x9gknd 2810 28 Karafa Karafa NNP cord-010119-t1x9gknd 2810 29 SW SW NNP cord-010119-t1x9gknd 2810 30 Badjie Badjie NNP cord-010119-t1x9gknd 2810 31 1 1 CD cord-010119-t1x9gknd 2810 32 and and CC cord-010119-t1x9gknd 2810 33 Abba Abba NNP cord-010119-t1x9gknd 2810 34 Zubair Zubair NNP cord-010119-t1x9gknd 2810 35 1 1 CD cord-010119-t1x9gknd 2810 36 . . . cord-010119-t1x9gknd 2811 1 1 1 LS cord-010119-t1x9gknd 2811 2 Department Department NNP cord-010119-t1x9gknd 2811 3 of of IN cord-010119-t1x9gknd 2811 4 Laboratory Laboratory NNP cord-010119-t1x9gknd 2811 5 Medicine Medicine NNP cord-010119-t1x9gknd 2811 6 and and CC cord-010119-t1x9gknd 2811 7 Pathology Pathology NNP cord-010119-t1x9gknd 2811 8 , , , cord-010119-t1x9gknd 2811 9 Transfusion Transfusion NNP cord-010119-t1x9gknd 2811 10 Medicine Medicine NNP cord-010119-t1x9gknd 2811 11 , , , cord-010119-t1x9gknd 2811 12 Mayo Mayo NNP cord-010119-t1x9gknd 2811 13 Clinic Clinic NNP cord-010119-t1x9gknd 2811 14 , , , cord-010119-t1x9gknd 2811 15 2 2 CD cord-010119-t1x9gknd 2811 16 Department Department NNP cord-010119-t1x9gknd 2811 17 of of IN cord-010119-t1x9gknd 2811 18 Anesthesia Anesthesia NNP cord-010119-t1x9gknd 2811 19 , , , cord-010119-t1x9gknd 2811 20 Mayo Mayo NNP cord-010119-t1x9gknd 2811 21 Clinic Clinic NNP cord-010119-t1x9gknd 2811 22 Background Background NNP cord-010119-t1x9gknd 2811 23 / / SYM cord-010119-t1x9gknd 2811 24 Case Case NNP cord-010119-t1x9gknd 2811 25 Studies Studies NNPS cord-010119-t1x9gknd 2811 26 : : : cord-010119-t1x9gknd 2811 27 Our -PRON- PRP$ cord-010119-t1x9gknd 2811 28 institution institution NN cord-010119-t1x9gknd 2811 29 performs perform VBZ cord-010119-t1x9gknd 2811 30 an an DT cord-010119-t1x9gknd 2811 31 average average NN cord-010119-t1x9gknd 2811 32 of of IN cord-010119-t1x9gknd 2811 33 398 398 CD cord-010119-t1x9gknd 2811 34 solid solid JJ cord-010119-t1x9gknd 2811 35 organ organ NN cord-010119-t1x9gknd 2811 36 transplants transplant NNS cord-010119-t1x9gknd 2811 37 ( ( -LRB- cord-010119-t1x9gknd 2811 38 SOTs sot NNS cord-010119-t1x9gknd 2811 39 ) ) -RRB- cord-010119-t1x9gknd 2811 40 yearly yearly RB cord-010119-t1x9gknd 2811 41 . . . cord-010119-t1x9gknd 2812 1 Transfusion transfusion NN cord-010119-t1x9gknd 2812 2 support support NN cord-010119-t1x9gknd 2812 3 for for IN cord-010119-t1x9gknd 2812 4 transplants transplant NNS cord-010119-t1x9gknd 2812 5 can can MD cord-010119-t1x9gknd 2812 6 be be VB cord-010119-t1x9gknd 2812 7 tremendous tremendous JJ cord-010119-t1x9gknd 2812 8 , , , cord-010119-t1x9gknd 2812 9 accounting account VBG cord-010119-t1x9gknd 2812 10 for for IN cord-010119-t1x9gknd 2812 11 a a DT cord-010119-t1x9gknd 2812 12 large large JJ cord-010119-t1x9gknd 2812 13 percentage percentage NN cord-010119-t1x9gknd 2812 14 of of IN cord-010119-t1x9gknd 2812 15 red red JJ cord-010119-t1x9gknd 2812 16 blood blood NN cord-010119-t1x9gknd 2812 17 cell cell NN cord-010119-t1x9gknd 2812 18 ( ( -LRB- cord-010119-t1x9gknd 2812 19 RBC RBC NNP cord-010119-t1x9gknd 2812 20 ) ) -RRB- cord-010119-t1x9gknd 2812 21 transfusions transfusion NNS cord-010119-t1x9gknd 2812 22 annually annually RB cord-010119-t1x9gknd 2812 23 . . . cord-010119-t1x9gknd 2813 1 Even even RB cord-010119-t1x9gknd 2813 2 the the DT cord-010119-t1x9gknd 2813 3 best good JJS cord-010119-t1x9gknd 2813 4 practices practice NNS cord-010119-t1x9gknd 2813 5 for for IN cord-010119-t1x9gknd 2813 6 allogeneic allogeneic NN cord-010119-t1x9gknd 2813 7 transfusion transfusion NN cord-010119-t1x9gknd 2813 8 are be VBP cord-010119-t1x9gknd 2813 9 not not RB cord-010119-t1x9gknd 2813 10 without without IN cord-010119-t1x9gknd 2813 11 risk risk NN cord-010119-t1x9gknd 2813 12 . . . cord-010119-t1x9gknd 2814 1 Transmission transmission NN cord-010119-t1x9gknd 2814 2 of of IN cord-010119-t1x9gknd 2814 3 pathogens pathogen NNS cord-010119-t1x9gknd 2814 4 is be VBZ cord-010119-t1x9gknd 2814 5 possible possible JJ cord-010119-t1x9gknd 2814 6 with with IN cord-010119-t1x9gknd 2814 7 even even RB cord-010119-t1x9gknd 2814 8 the the DT cord-010119-t1x9gknd 2814 9 strictest strict JJS cord-010119-t1x9gknd 2814 10 screening screening NN cord-010119-t1x9gknd 2814 11 methods method NNS cord-010119-t1x9gknd 2814 12 , , , cord-010119-t1x9gknd 2814 13 and and CC cord-010119-t1x9gknd 2814 14 each each DT cord-010119-t1x9gknd 2814 15 transfusion transfusion NN cord-010119-t1x9gknd 2814 16 increases increase VBZ cord-010119-t1x9gknd 2814 17 the the DT cord-010119-t1x9gknd 2814 18 risk risk NN cord-010119-t1x9gknd 2814 19 of of IN cord-010119-t1x9gknd 2814 20 alloimmunization alloimmunization NN cord-010119-t1x9gknd 2814 21 . . . cord-010119-t1x9gknd 2815 1 The the DT cord-010119-t1x9gknd 2815 2 advent advent NN cord-010119-t1x9gknd 2815 3 of of IN cord-010119-t1x9gknd 2815 4 intraoperative intraoperative JJ cord-010119-t1x9gknd 2815 5 blood blood NN cord-010119-t1x9gknd 2815 6 recovery recovery NN cord-010119-t1x9gknd 2815 7 has have VBZ cord-010119-t1x9gknd 2815 8 reduced reduce VBN cord-010119-t1x9gknd 2815 9 the the DT cord-010119-t1x9gknd 2815 10 need need NN cord-010119-t1x9gknd 2815 11 for for IN cord-010119-t1x9gknd 2815 12 allogeneic allogeneic NN cord-010119-t1x9gknd 2815 13 donor donor NN cord-010119-t1x9gknd 2815 14 RBCs rbc NNS cord-010119-t1x9gknd 2815 15 during during IN cord-010119-t1x9gknd 2815 16 surgeries surgery NNS cord-010119-t1x9gknd 2815 17 expected expect VBN cord-010119-t1x9gknd 2815 18 to to TO cord-010119-t1x9gknd 2815 19 bleed bleed VB cord-010119-t1x9gknd 2815 20 heavily heavily RB cord-010119-t1x9gknd 2815 21 . . . cord-010119-t1x9gknd 2816 1 With with IN cord-010119-t1x9gknd 2816 2 the the DT cord-010119-t1x9gknd 2816 3 Cell cell NN cord-010119-t1x9gknd 2816 4 SaverV SaverV NNS cord-010119-t1x9gknd 2816 5 R r NN cord-010119-t1x9gknd 2816 6 ( ( -LRB- cord-010119-t1x9gknd 2816 7 HaemoneticsV HaemoneticsV NNP cord-010119-t1x9gknd 2816 8 R R NNP cord-010119-t1x9gknd 2816 9 , , , cord-010119-t1x9gknd 2816 10 Braintree Braintree NNP cord-010119-t1x9gknd 2816 11 , , , cord-010119-t1x9gknd 2816 12 MA MA NNP cord-010119-t1x9gknd 2816 13 ) ) -RRB- cord-010119-t1x9gknd 2816 14 , , , cord-010119-t1x9gknd 2816 15 patients patient NNS cord-010119-t1x9gknd 2816 16 ' ' POS cord-010119-t1x9gknd 2816 17 own own JJ cord-010119-t1x9gknd 2816 18 blood blood NN cord-010119-t1x9gknd 2816 19 shed shed VBN cord-010119-t1x9gknd 2816 20 during during IN cord-010119-t1x9gknd 2816 21 surgery surgery NN cord-010119-t1x9gknd 2816 22 is be VBZ cord-010119-t1x9gknd 2816 23 collected collect VBN cord-010119-t1x9gknd 2816 24 , , , cord-010119-t1x9gknd 2816 25 washed wash VBN cord-010119-t1x9gknd 2816 26 , , , cord-010119-t1x9gknd 2816 27 concentrated concentrate VBN cord-010119-t1x9gknd 2816 28 , , , cord-010119-t1x9gknd 2816 29 and and CC cord-010119-t1x9gknd 2816 30 reinfused reinfuse VBD cord-010119-t1x9gknd 2816 31 , , , cord-010119-t1x9gknd 2816 32 lessening lessen VBG cord-010119-t1x9gknd 2816 33 the the DT cord-010119-t1x9gknd 2816 34 need need NN cord-010119-t1x9gknd 2816 35 for for IN cord-010119-t1x9gknd 2816 36 transfusion transfusion NN cord-010119-t1x9gknd 2816 37 support support NN cord-010119-t1x9gknd 2816 38 . . . cord-010119-t1x9gknd 2817 1 This this DT cord-010119-t1x9gknd 2817 2 study study NN cord-010119-t1x9gknd 2817 3 sought seek VBD cord-010119-t1x9gknd 2817 4 to to TO cord-010119-t1x9gknd 2817 5 examine examine VB cord-010119-t1x9gknd 2817 6 the the DT cord-010119-t1x9gknd 2817 7 amount amount NN cord-010119-t1x9gknd 2817 8 of of IN cord-010119-t1x9gknd 2817 9 allogeneic allogeneic NN cord-010119-t1x9gknd 2817 10 donor donor NN cord-010119-t1x9gknd 2817 11 RBC RBC NNP cord-010119-t1x9gknd 2817 12 units unit NNS cord-010119-t1x9gknd 2817 13 saved save VBD cord-010119-t1x9gknd 2817 14 during during IN cord-010119-t1x9gknd 2817 15 SOTs sot NNS cord-010119-t1x9gknd 2817 16 through through IN cord-010119-t1x9gknd 2817 17 the the DT cord-010119-t1x9gknd 2817 18 use use NN cord-010119-t1x9gknd 2817 19 of of IN cord-010119-t1x9gknd 2817 20 the the DT cord-010119-t1x9gknd 2817 21 Cell Cell NNP cord-010119-t1x9gknd 2817 22 Saver Saver NNP cord-010119-t1x9gknd 2817 23 for for IN cord-010119-t1x9gknd 2817 24 intraoperative intraoperative JJ cord-010119-t1x9gknd 2817 25 blood blood NN cord-010119-t1x9gknd 2817 26 recovery recovery NN cord-010119-t1x9gknd 2817 27 . . . cord-010119-t1x9gknd 2818 1 Study Study NNP cord-010119-t1x9gknd 2818 2 Design Design NNP cord-010119-t1x9gknd 2818 3 / / SYM cord-010119-t1x9gknd 2818 4 Methods method NNS cord-010119-t1x9gknd 2818 5 : : : cord-010119-t1x9gknd 2818 6 Data Data NNP cord-010119-t1x9gknd 2818 7 was be VBD cord-010119-t1x9gknd 2818 8 collected collect VBN cord-010119-t1x9gknd 2818 9 for for IN cord-010119-t1x9gknd 2818 10 SOTs sot NNS cord-010119-t1x9gknd 2818 11 which which WDT cord-010119-t1x9gknd 2818 12 utilized utilize VBD cord-010119-t1x9gknd 2818 13 the the DT cord-010119-t1x9gknd 2818 14 Cell Cell NNP cord-010119-t1x9gknd 2818 15 Saver Saver NNP cord-010119-t1x9gknd 2818 16 . . . cord-010119-t1x9gknd 2819 1 These these DT cord-010119-t1x9gknd 2819 2 included include VBD cord-010119-t1x9gknd 2819 3 liver liver NN cord-010119-t1x9gknd 2819 4 , , , cord-010119-t1x9gknd 2819 5 liver liver NN cord-010119-t1x9gknd 2819 6 / / SYM cord-010119-t1x9gknd 2819 7 kidney kidney NN cord-010119-t1x9gknd 2819 8 combination combination NN cord-010119-t1x9gknd 2819 9 , , , cord-010119-t1x9gknd 2819 10 lung lung NN cord-010119-t1x9gknd 2819 11 , , , cord-010119-t1x9gknd 2819 12 and and CC cord-010119-t1x9gknd 2819 13 heart heart NN cord-010119-t1x9gknd 2819 14 transplants transplant NNS cord-010119-t1x9gknd 2819 15 . . . cord-010119-t1x9gknd 2820 1 Data datum NNS cord-010119-t1x9gknd 2820 2 A A NNP cord-010119-t1x9gknd 2820 3 29 29 CD cord-010119-t1x9gknd 2820 4 y.o y.o NNP cord-010119-t1x9gknd 2820 5 . . NNP cord-010119-t1x9gknd 2820 6 female female NN cord-010119-t1x9gknd 2820 7 was be VBD cord-010119-t1x9gknd 2820 8 admitted admit VBN cord-010119-t1x9gknd 2820 9 to to IN cord-010119-t1x9gknd 2820 10 the the DT cord-010119-t1x9gknd 2820 11 trauma trauma NN cord-010119-t1x9gknd 2820 12 department department NN cord-010119-t1x9gknd 2820 13 after after IN cord-010119-t1x9gknd 2820 14 a a DT cord-010119-t1x9gknd 2820 15 motor motor NN cord-010119-t1x9gknd 2820 16 vehicle vehicle NN cord-010119-t1x9gknd 2820 17 collision collision NN cord-010119-t1x9gknd 2820 18 ( ( -LRB- cord-010119-t1x9gknd 2820 19 MVC MVC NNP cord-010119-t1x9gknd 2820 20 ) ) -RRB- cord-010119-t1x9gknd 2820 21 and and CC cord-010119-t1x9gknd 2820 22 transfused transfuse VBD cord-010119-t1x9gknd 2820 23 2 2 CD cord-010119-t1x9gknd 2820 24 O(1 O(1 NNP cord-010119-t1x9gknd 2820 25 ) ) -RRB- cord-010119-t1x9gknd 2820 26 RBC RBC NNP cord-010119-t1x9gknd 2820 27 units unit NNS cord-010119-t1x9gknd 2820 28 from from IN cord-010119-t1x9gknd 2820 29 the the DT cord-010119-t1x9gknd 2820 30 kiosk kiosk NN cord-010119-t1x9gknd 2820 31 . . . cord-010119-t1x9gknd 2821 1 Her -PRON- PRP$ cord-010119-t1x9gknd 2821 2 blood blood NN cord-010119-t1x9gknd 2821 3 type type NN cord-010119-t1x9gknd 2821 4 was be VBD cord-010119-t1x9gknd 2821 5 determined determine VBN cord-010119-t1x9gknd 2821 6 as as IN cord-010119-t1x9gknd 2821 7 O(- O(- NNP cord-010119-t1x9gknd 2821 8 ) ) -RRB- cord-010119-t1x9gknd 2821 9 with with IN cord-010119-t1x9gknd 2821 10 a a DT cord-010119-t1x9gknd 2821 11 negative negative JJ cord-010119-t1x9gknd 2821 12 RBC RBC NNP cord-010119-t1x9gknd 2821 13 antibody antibody NN cord-010119-t1x9gknd 2821 14 screen screen NN cord-010119-t1x9gknd 2821 15 ( ( -LRB- cord-010119-t1x9gknd 2821 16 AS AS NNP cord-010119-t1x9gknd 2821 17 ) ) -RRB- cord-010119-t1x9gknd 2821 18 . . . cord-010119-t1x9gknd 2822 1 She -PRON- PRP cord-010119-t1x9gknd 2822 2 was be VBD cord-010119-t1x9gknd 2822 3 transfused transfuse VBN cord-010119-t1x9gknd 2822 4 10 10 CD cord-010119-t1x9gknd 2822 5 more more JJR cord-010119-t1x9gknd 2822 6 units unit NNS cord-010119-t1x9gknd 2822 7 of of IN cord-010119-t1x9gknd 2822 8 O(- O(- NNP cord-010119-t1x9gknd 2822 9 ) ) -RRB- cord-010119-t1x9gknd 2822 10 RBC RBC NNP cord-010119-t1x9gknd 2822 11 . . . cord-010119-t1x9gknd 2823 1 Two two CD cord-010119-t1x9gknd 2823 2 months month NNS cord-010119-t1x9gknd 2823 3 later later RB cord-010119-t1x9gknd 2823 4 , , , cord-010119-t1x9gknd 2823 5 a a DT cord-010119-t1x9gknd 2823 6 repeat repeat NN cord-010119-t1x9gknd 2823 7 AS as IN cord-010119-t1x9gknd 2823 8 identified identify VBD cord-010119-t1x9gknd 2823 9 two two CD cord-010119-t1x9gknd 2823 10 new new JJ cord-010119-t1x9gknd 2823 11 RBC RBC NNP cord-010119-t1x9gknd 2823 12 alloantibodies alloantibody NNS cord-010119-t1x9gknd 2823 13 , , , cord-010119-t1x9gknd 2823 14 anti anti JJ cord-010119-t1x9gknd 2823 15 - - JJ cord-010119-t1x9gknd 2823 16 D d JJ cord-010119-t1x9gknd 2823 17 and and CC cord-010119-t1x9gknd 2823 18 anti anti JJ cord-010119-t1x9gknd 2823 19 - - JJ cord-010119-t1x9gknd 2823 20 E. e. JJ cord-010119-t1x9gknd 2824 1 The the DT cord-010119-t1x9gknd 2824 2 anti anti JJ cord-010119-t1x9gknd 2824 3 - - JJ cord-010119-t1x9gknd 2824 4 D d JJ cord-010119-t1x9gknd 2824 5 formation formation NN cord-010119-t1x9gknd 2824 6 resulted result VBD cord-010119-t1x9gknd 2824 7 from from IN cord-010119-t1x9gknd 2824 8 the the DT cord-010119-t1x9gknd 2824 9 2 2 CD cord-010119-t1x9gknd 2824 10 O(1 O(1 NNP cord-010119-t1x9gknd 2824 11 ) ) -RRB- cord-010119-t1x9gknd 2824 12 RBC RBC NNP cord-010119-t1x9gknd 2824 13 transfused transfuse VBD cord-010119-t1x9gknd 2824 14 from from IN cord-010119-t1x9gknd 2824 15 the the DT cord-010119-t1x9gknd 2824 16 kiosk kiosk NN cord-010119-t1x9gknd 2824 17 , , , cord-010119-t1x9gknd 2824 18 but but CC cord-010119-t1x9gknd 2824 19 the the DT cord-010119-t1x9gknd 2824 20 source source NN cord-010119-t1x9gknd 2824 21 of of IN cord-010119-t1x9gknd 2824 22 the the DT cord-010119-t1x9gknd 2824 23 anti anti JJ cord-010119-t1x9gknd 2824 24 - - NN cord-010119-t1x9gknd 2824 25 E E NNP cord-010119-t1x9gknd 2824 26 was be VBD cord-010119-t1x9gknd 2824 27 undetermined undetermined JJ cord-010119-t1x9gknd 2824 28 since since IN cord-010119-t1x9gknd 2824 29 E e NN cord-010119-t1x9gknd 2824 30 antigen antigen NN cord-010119-t1x9gknd 2824 31 is be VBZ cord-010119-t1x9gknd 2824 32 expressed express VBN cord-010119-t1x9gknd 2824 33 in in IN cord-010119-t1x9gknd 2824 34 1 1 CD cord-010119-t1x9gknd 2824 35 % % NN cord-010119-t1x9gknd 2824 36 of of IN cord-010119-t1x9gknd 2824 37 Rh(- Rh(- NNP cord-010119-t1x9gknd 2824 38 ) ) -RRB- cord-010119-t1x9gknd 2824 39 individuals individual NNS cord-010119-t1x9gknd 2824 40 . . . cord-010119-t1x9gknd 2825 1 The the DT cord-010119-t1x9gknd 2825 2 trauma trauma NN cord-010119-t1x9gknd 2825 3 department department NN cord-010119-t1x9gknd 2825 4 staff staff NN cord-010119-t1x9gknd 2825 5 was be VBD cord-010119-t1x9gknd 2825 6 notified notify VBN cord-010119-t1x9gknd 2825 7 of of IN cord-010119-t1x9gknd 2825 8 delayed delay VBN cord-010119-t1x9gknd 2825 9 serologic serologic JJ cord-010119-t1x9gknd 2825 10 transfusion transfusion NN cord-010119-t1x9gknd 2825 11 reaction reaction NN cord-010119-t1x9gknd 2825 12 and and CC cord-010119-t1x9gknd 2825 13 asked ask VBD cord-010119-t1x9gknd 2825 14 to to TO cord-010119-t1x9gknd 2825 15 investigate investigate VB cord-010119-t1x9gknd 2825 16 further further RB cord-010119-t1x9gknd 2825 17 since since IN cord-010119-t1x9gknd 2825 18 a a DT cord-010119-t1x9gknd 2825 19 29 29 CD cord-010119-t1x9gknd 2825 20 y.o y.o NNP cord-010119-t1x9gknd 2825 21 . . NNP cord-010119-t1x9gknd 2825 22 female female JJ cord-010119-t1x9gknd 2825 23 patient patient NN cord-010119-t1x9gknd 2825 24 should should MD cord-010119-t1x9gknd 2825 25 not not RB cord-010119-t1x9gknd 2825 26 have have VB cord-010119-t1x9gknd 2825 27 received receive VBN cord-010119-t1x9gknd 2825 28 O(1 O(1 '' cord-010119-t1x9gknd 2825 29 ) ) -RRB- cord-010119-t1x9gknd 2825 30 RBCs rbc NNS cord-010119-t1x9gknd 2825 31 . . . cord-010119-t1x9gknd 2826 1 Study Study NNP cord-010119-t1x9gknd 2826 2 Design Design NNP cord-010119-t1x9gknd 2826 3 / / SYM cord-010119-t1x9gknd 2826 4 Method method NN cord-010119-t1x9gknd 2826 5 : : : cord-010119-t1x9gknd 2827 1 An an DT cord-010119-t1x9gknd 2827 2 investigative investigative JJ cord-010119-t1x9gknd 2827 3 plan plan NN cord-010119-t1x9gknd 2827 4 was be VBD cord-010119-t1x9gknd 2827 5 developed develop VBN cord-010119-t1x9gknd 2827 6 by by IN cord-010119-t1x9gknd 2827 7 the the DT cord-010119-t1x9gknd 2827 8 trauma trauma NN cord-010119-t1x9gknd 2827 9 staff staff NN cord-010119-t1x9gknd 2827 10 involving involve VBG cord-010119-t1x9gknd 2827 11 a a DT cord-010119-t1x9gknd 2827 12 patient patient JJ cord-010119-t1x9gknd 2827 13 census census NN cord-010119-t1x9gknd 2827 14 , , , cord-010119-t1x9gknd 2827 15 review review NN cord-010119-t1x9gknd 2827 16 of of IN cord-010119-t1x9gknd 2827 17 the the DT cord-010119-t1x9gknd 2827 18 chart chart NN cord-010119-t1x9gknd 2827 19 and and CC cord-010119-t1x9gknd 2827 20 kiosk kiosk NN cord-010119-t1x9gknd 2827 21 inventory inventory NN cord-010119-t1x9gknd 2827 22 , , , cord-010119-t1x9gknd 2827 23 obtaining obtain VBG cord-010119-t1x9gknd 2827 24 feedback feedback NN cord-010119-t1x9gknd 2827 25 from from IN cord-010119-t1x9gknd 2827 26 clinical clinical JJ cord-010119-t1x9gknd 2827 27 providers provider NNS cord-010119-t1x9gknd 2827 28 , , , cord-010119-t1x9gknd 2827 29 and and CC cord-010119-t1x9gknd 2827 30 review review NN cord-010119-t1x9gknd 2827 31 of of IN cord-010119-t1x9gknd 2827 32 information information NN cord-010119-t1x9gknd 2827 33 provided provide VBN cord-010119-t1x9gknd 2827 34 by by IN cord-010119-t1x9gknd 2827 35 emergency emergency NN cord-010119-t1x9gknd 2827 36 services service NNS cord-010119-t1x9gknd 2827 37 ( ( -LRB- cord-010119-t1x9gknd 2827 38 EMS EMS NNP cord-010119-t1x9gknd 2827 39 ) ) -RRB- cord-010119-t1x9gknd 2827 40 . . . cord-010119-t1x9gknd 2828 1 Results/ Results/ . cord-010119-t1x9gknd 2829 1 Finding find VBG cord-010119-t1x9gknd 2829 2 : : : cord-010119-t1x9gknd 2829 3 The the DT cord-010119-t1x9gknd 2829 4 trauma trauma NN cord-010119-t1x9gknd 2829 5 unit unit NN cord-010119-t1x9gknd 2829 6 was be VBD cord-010119-t1x9gknd 2829 7 busy busy JJ cord-010119-t1x9gknd 2829 8 with with IN cord-010119-t1x9gknd 2829 9 10 10 CD cord-010119-t1x9gknd 2829 10 admissions admission NNS cord-010119-t1x9gknd 2829 11 during during IN cord-010119-t1x9gknd 2829 12 the the DT cord-010119-t1x9gknd 2829 13 5 5 CD cord-010119-t1x9gknd 2829 14 hours hour NNS cord-010119-t1x9gknd 2829 15 preceding precede VBG cord-010119-t1x9gknd 2829 16 the the DT cord-010119-t1x9gknd 2829 17 patient patient NN cord-010119-t1x9gknd 2829 18 's 's POS cord-010119-t1x9gknd 2829 19 arrival arrival NN cord-010119-t1x9gknd 2829 20 . . . cord-010119-t1x9gknd 2830 1 The the DT cord-010119-t1x9gknd 2830 2 chart chart NN cord-010119-t1x9gknd 2830 3 review review NN cord-010119-t1x9gknd 2830 4 found find VBD cord-010119-t1x9gknd 2830 5 the the DT cord-010119-t1x9gknd 2830 6 following following JJ cord-010119-t1x9gknd 2830 7 physical physical JJ cord-010119-t1x9gknd 2830 8 attributes attribute NNS cord-010119-t1x9gknd 2830 9 ; ; : cord-010119-t1x9gknd 2830 10 patient patient JJ cord-010119-t1x9gknd 2830 11 was be VBD cord-010119-t1x9gknd 2830 12 overweight overweight JJ cord-010119-t1x9gknd 2830 13 ( ( -LRB- cord-010119-t1x9gknd 2830 14 107 107 CD cord-010119-t1x9gknd 2830 15 kg kg NN cord-010119-t1x9gknd 2830 16 ) ) -RRB- cord-010119-t1x9gknd 2830 17 with with IN cord-010119-t1x9gknd 2830 18 obvious obvious JJ cord-010119-t1x9gknd 2830 19 facial facial JJ cord-010119-t1x9gknd 2830 20 deformities deformity NNS cord-010119-t1x9gknd 2830 21 from from IN cord-010119-t1x9gknd 2830 22 the the DT cord-010119-t1x9gknd 2830 23 MVC MVC NNP cord-010119-t1x9gknd 2830 24 , , , cord-010119-t1x9gknd 2830 25 that that IN cord-010119-t1x9gknd 2830 26 compromised compromise VBN cord-010119-t1x9gknd 2830 27 age age NN cord-010119-t1x9gknd 2830 28 assessment assessment NN cord-010119-t1x9gknd 2830 29 . . . cord-010119-t1x9gknd 2831 1 It -PRON- PRP cord-010119-t1x9gknd 2831 2 was be VBD cord-010119-t1x9gknd 2831 3 determined determine VBN cord-010119-t1x9gknd 2831 4 that that IN cord-010119-t1x9gknd 2831 5 the the DT cord-010119-t1x9gknd 2831 6 kiosk kiosk NN cord-010119-t1x9gknd 2831 7 was be VBD cord-010119-t1x9gknd 2831 8 fully fully RB cord-010119-t1x9gknd 2831 9 stocked stock VBN cord-010119-t1x9gknd 2831 10 with with IN cord-010119-t1x9gknd 2831 11 both both DT cord-010119-t1x9gknd 2831 12 O(- O(- NNP cord-010119-t1x9gknd 2831 13 ) ) -RRB- cord-010119-t1x9gknd 2831 14 and and CC cord-010119-t1x9gknd 2831 15 O(1 O(1 NNP cord-010119-t1x9gknd 2831 16 ) ) -RRB- cord-010119-t1x9gknd 2831 17 RBC RBC NNP cord-010119-t1x9gknd 2831 18 units unit NNS cord-010119-t1x9gknd 2831 19 . . . cord-010119-t1x9gknd 2832 1 One one CD cord-010119-t1x9gknd 2832 2 clinical clinical JJ cord-010119-t1x9gknd 2832 3 provider provider NN cord-010119-t1x9gknd 2832 4 recalls recall VBZ cord-010119-t1x9gknd 2832 5 that that IN cord-010119-t1x9gknd 2832 6 the the DT cord-010119-t1x9gknd 2832 7 patient patient NN cord-010119-t1x9gknd 2832 8 identification identification NN cord-010119-t1x9gknd 2832 9 ( ( -LRB- cord-010119-t1x9gknd 2832 10 ID ID NNP cord-010119-t1x9gknd 2832 11 ) ) -RRB- cord-010119-t1x9gknd 2832 12 might may MD cord-010119-t1x9gknd 2832 13 have have VB cord-010119-t1x9gknd 2832 14 been be VBN cord-010119-t1x9gknd 2832 15 unknown unknown JJ cord-010119-t1x9gknd 2832 16 . . . cord-010119-t1x9gknd 2833 1 Review Review NNP cord-010119-t1x9gknd 2833 2 of of IN cord-010119-t1x9gknd 2833 3 the the DT cord-010119-t1x9gknd 2833 4 EMS EMS NNP cord-010119-t1x9gknd 2833 5 communication communication NN cord-010119-t1x9gknd 2833 6 states state NNS cord-010119-t1x9gknd 2833 7 " " `` cord-010119-t1x9gknd 2833 8 patient patient NN cord-010119-t1x9gknd 2833 9 is be VBZ cord-010119-t1x9gknd 2833 10 a a DT cord-010119-t1x9gknd 2833 11 50 50 CD cord-010119-t1x9gknd 2833 12 y.o y.o NNP cord-010119-t1x9gknd 2833 13 . . NNP cord-010119-t1x9gknd 2833 14 female female NN cord-010119-t1x9gknd 2833 15 . . . cord-010119-t1x9gknd 2834 1 " " '' cord-010119-t1x9gknd 2835 1 Conclusion conclusion NN cord-010119-t1x9gknd 2835 2 : : : cord-010119-t1x9gknd 2835 3 Use use NN cord-010119-t1x9gknd 2835 4 of of IN cord-010119-t1x9gknd 2835 5 visual visual JJ cord-010119-t1x9gknd 2835 6 examination examination NN cord-010119-t1x9gknd 2835 7 to to TO cord-010119-t1x9gknd 2835 8 determine determine VB cord-010119-t1x9gknd 2835 9 age age NN cord-010119-t1x9gknd 2835 10 was be VBD cord-010119-t1x9gknd 2835 11 significant significant JJ cord-010119-t1x9gknd 2835 12 in in IN cord-010119-t1x9gknd 2835 13 the the DT cord-010119-t1x9gknd 2835 14 selection selection NN cord-010119-t1x9gknd 2835 15 of of IN cord-010119-t1x9gknd 2835 16 O(1 O(1 NNP cord-010119-t1x9gknd 2835 17 ) ) -RRB- cord-010119-t1x9gknd 2835 18 RBC RBC NNP cord-010119-t1x9gknd 2835 19 for for IN cord-010119-t1x9gknd 2835 20 this this DT cord-010119-t1x9gknd 2835 21 patient patient NN cord-010119-t1x9gknd 2835 22 . . . cord-010119-t1x9gknd 2836 1 The the DT cord-010119-t1x9gknd 2836 2 trauma trauma NN cord-010119-t1x9gknd 2836 3 staff staff NN cord-010119-t1x9gknd 2836 4 proposed propose VBD cord-010119-t1x9gknd 2836 5 and and CC cord-010119-t1x9gknd 2836 6 implemented implement VBD cord-010119-t1x9gknd 2836 7 a a DT cord-010119-t1x9gknd 2836 8 change change NN cord-010119-t1x9gknd 2836 9 in in IN cord-010119-t1x9gknd 2836 10 policy policy NN cord-010119-t1x9gknd 2836 11 to to TO cord-010119-t1x9gknd 2836 12 prevent prevent VB cord-010119-t1x9gknd 2836 13 future future JJ cord-010119-t1x9gknd 2836 14 incidents incident NNS cord-010119-t1x9gknd 2836 15 . . . cord-010119-t1x9gknd 2837 1 Any any DT cord-010119-t1x9gknd 2837 2 female female JJ cord-010119-t1x9gknd 2837 3 patient patient NN cord-010119-t1x9gknd 2837 4 that that WDT cord-010119-t1x9gknd 2837 5 arrives arrive VBZ cord-010119-t1x9gknd 2837 6 without without IN cord-010119-t1x9gknd 2837 7 ID ID NNP cord-010119-t1x9gknd 2837 8 or or CC cord-010119-t1x9gknd 2837 9 written write VBN cord-010119-t1x9gknd 2837 10 confirmation confirmation NN cord-010119-t1x9gknd 2837 11 of of IN cord-010119-t1x9gknd 2837 12 age age NN cord-010119-t1x9gknd 2837 13 will will MD cord-010119-t1x9gknd 2837 14 be be VB cord-010119-t1x9gknd 2837 15 transfused transfuse VBN cord-010119-t1x9gknd 2837 16 O(- O(- NNP cord-010119-t1x9gknd 2837 17 ) ) -RRB- cord-010119-t1x9gknd 2837 18 uncrossmatched uncrossmatche VBD cord-010119-t1x9gknd 2837 19 RBC RBC NNP cord-010119-t1x9gknd 2837 20 until until IN cord-010119-t1x9gknd 2837 21 a a DT cord-010119-t1x9gknd 2837 22 blood blood NN cord-010119-t1x9gknd 2837 23 type type NN cord-010119-t1x9gknd 2837 24 can can MD cord-010119-t1x9gknd 2837 25 be be VB cord-010119-t1x9gknd 2837 26 determined determine VBN cord-010119-t1x9gknd 2837 27 . . . cord-010119-t1x9gknd 2838 1 After after IN cord-010119-t1x9gknd 2838 2 being be VBG cord-010119-t1x9gknd 2838 3 notified notify VBN cord-010119-t1x9gknd 2838 4 of of IN cord-010119-t1x9gknd 2838 5 the the DT cord-010119-t1x9gknd 2838 6 incident incident NN cord-010119-t1x9gknd 2838 7 , , , cord-010119-t1x9gknd 2838 8 the the DT cord-010119-t1x9gknd 2838 9 trauma trauma NN cord-010119-t1x9gknd 2838 10 staff staff NN cord-010119-t1x9gknd 2838 11 took take VBD cord-010119-t1x9gknd 2838 12 the the DT cord-010119-t1x9gknd 2838 13 lead lead NN cord-010119-t1x9gknd 2838 14 in in IN cord-010119-t1x9gknd 2838 15 investigating investigate VBG cord-010119-t1x9gknd 2838 16 and and CC cord-010119-t1x9gknd 2838 17 providing provide VBG cord-010119-t1x9gknd 2838 18 a a DT cord-010119-t1x9gknd 2838 19 process process NN cord-010119-t1x9gknd 2838 20 improvement improvement NN cord-010119-t1x9gknd 2838 21 resolution resolution NN cord-010119-t1x9gknd 2838 22 . . . cord-010119-t1x9gknd 2839 1 This this DT cord-010119-t1x9gknd 2839 2 is be VBZ cord-010119-t1x9gknd 2839 3 credited credit VBN cord-010119-t1x9gknd 2839 4 to to IN cord-010119-t1x9gknd 2839 5 the the DT cord-010119-t1x9gknd 2839 6 excellent excellent JJ cord-010119-t1x9gknd 2839 7 collaborative collaborative JJ cord-010119-t1x9gknd 2839 8 relationship relationship NN cord-010119-t1x9gknd 2839 9 between between IN cord-010119-t1x9gknd 2839 10 the the DT cord-010119-t1x9gknd 2839 11 transfusion transfusion NN cord-010119-t1x9gknd 2839 12 service service NN cord-010119-t1x9gknd 2839 13 and and CC cord-010119-t1x9gknd 2839 14 trauma trauma NN cord-010119-t1x9gknd 2839 15 department department NN cord-010119-t1x9gknd 2839 16 on on IN cord-010119-t1x9gknd 2839 17 ensuring ensure VBG cord-010119-t1x9gknd 2839 18 patient patient JJ cord-010119-t1x9gknd 2839 19 safety safety NN cord-010119-t1x9gknd 2839 20 during during IN cord-010119-t1x9gknd 2839 21 emergent emergent JJ cord-010119-t1x9gknd 2839 22 , , , cord-010119-t1x9gknd 2839 23 uncrossmatched uncrossmatched JJ cord-010119-t1x9gknd 2839 24 RBC RBC NNP cord-010119-t1x9gknd 2839 25 transfusions transfusion NNS cord-010119-t1x9gknd 2839 26 . . . cord-010119-t1x9gknd 2840 1 Rate rate NN cord-010119-t1x9gknd 2840 2 of of IN cord-010119-t1x9gknd 2840 3 ABO ABO NNP cord-010119-t1x9gknd 2840 4 / / SYM cord-010119-t1x9gknd 2840 5 Rh Rh NNP cord-010119-t1x9gknd 2840 6 Confirmation Confirmation NNP cord-010119-t1x9gknd 2840 7 in in IN cord-010119-t1x9gknd 2840 8 Outpatient Outpatient NNP cord-010119-t1x9gknd 2840 9 Pelvic Pelvic NNP cord-010119-t1x9gknd 2840 10 Organ Organ NNP cord-010119-t1x9gknd 2840 11 Prolapse Prolapse NNP cord-010119-t1x9gknd 2840 12 Surgery surgery NN cord-010119-t1x9gknd 2840 13 Alexis Alexis NNP cord-010119-t1x9gknd 2840 14 R r NN cord-010119-t1x9gknd 2840 15 Peedin Peedin NNP cord-010119-t1x9gknd 2841 1 * * NFP cord-010119-t1x9gknd 2841 2 , , , cord-010119-t1x9gknd 2841 3 Taylor Taylor NNP cord-010119-t1x9gknd 2841 4 Brueseke Brueseke NNP cord-010119-t1x9gknd 2841 5 , , , cord-010119-t1x9gknd 2841 6 Yara Yara NNP cord-010119-t1x9gknd 2841 7 Park Park NNP cord-010119-t1x9gknd 2841 8 and and CC cord-010119-t1x9gknd 2841 9 Jay Jay NNP cord-010119-t1x9gknd 2841 10 S S NNP cord-010119-t1x9gknd 2841 11 Raval Raval NNP cord-010119-t1x9gknd 2841 12 . . . cord-010119-t1x9gknd 2842 1 University University NNP cord-010119-t1x9gknd 2842 2 of of IN cord-010119-t1x9gknd 2842 3 North North NNP cord-010119-t1x9gknd 2842 4 Carolina Carolina NNP cord-010119-t1x9gknd 2842 5 Background Background NNP cord-010119-t1x9gknd 2842 6 / / SYM cord-010119-t1x9gknd 2842 7 Case Case NNP cord-010119-t1x9gknd 2842 8 Studies Studies NNPS cord-010119-t1x9gknd 2842 9 : : : cord-010119-t1x9gknd 2842 10 Approximately approximately RB cord-010119-t1x9gknd 2842 11 375,000 375,000 CD cord-010119-t1x9gknd 2842 12 surgeries surgery NNS cord-010119-t1x9gknd 2842 13 for for IN cord-010119-t1x9gknd 2842 14 urinary urinary JJ cord-010119-t1x9gknd 2842 15 incontinence incontinence NN cord-010119-t1x9gknd 2842 16 or or CC cord-010119-t1x9gknd 2842 17 pelvic pelvic JJ cord-010119-t1x9gknd 2842 18 organ organ NN cord-010119-t1x9gknd 2842 19 prolapse prolapse NN cord-010119-t1x9gknd 2842 20 ( ( -LRB- cord-010119-t1x9gknd 2842 21 POP pop NN cord-010119-t1x9gknd 2842 22 ) ) -RRB- cord-010119-t1x9gknd 2842 23 are be VBP cord-010119-t1x9gknd 2842 24 performed perform VBN cord-010119-t1x9gknd 2842 25 annually annually RB cord-010119-t1x9gknd 2842 26 . . . cord-010119-t1x9gknd 2843 1 For for IN cord-010119-t1x9gknd 2843 2 abdominal abdominal JJ cord-010119-t1x9gknd 2843 3 pelvic pelvic JJ cord-010119-t1x9gknd 2843 4 floor floor NN cord-010119-t1x9gknd 2843 5 disorder disorder NN cord-010119-t1x9gknd 2843 6 ( ( -LRB- cord-010119-t1x9gknd 2843 7 PFD PFD NNP cord-010119-t1x9gknd 2843 8 ) ) -RRB- cord-010119-t1x9gknd 2843 9 surgeries surgery NNS cord-010119-t1x9gknd 2843 10 , , , cord-010119-t1x9gknd 2843 11 transfusion transfusion NN cord-010119-t1x9gknd 2843 12 rates rate NNS cord-010119-t1x9gknd 2843 13 historically historically RB cord-010119-t1x9gknd 2843 14 range range VBP cord-010119-t1x9gknd 2843 15 from from IN cord-010119-t1x9gknd 2843 16 6 6 CD cord-010119-t1x9gknd 2843 17 - - SYM cord-010119-t1x9gknd 2843 18 16 16 CD cord-010119-t1x9gknd 2843 19 % % NN cord-010119-t1x9gknd 2843 20 , , , cord-010119-t1x9gknd 2843 21 whereas whereas IN cord-010119-t1x9gknd 2843 22 transfusion transfusion NN cord-010119-t1x9gknd 2843 23 rates rate NNS cord-010119-t1x9gknd 2843 24 for for IN cord-010119-t1x9gknd 2843 25 vaginal vaginal JJ cord-010119-t1x9gknd 2843 26 and and CC cord-010119-t1x9gknd 2843 27 robotic robotic JJ cord-010119-t1x9gknd 2843 28 PFD PFD NNP cord-010119-t1x9gknd 2843 29 surgeries surgery NNS cord-010119-t1x9gknd 2843 30 range range VBP cord-010119-t1x9gknd 2843 31 from from IN cord-010119-t1x9gknd 2843 32 0.2 0.2 CD cord-010119-t1x9gknd 2843 33 - - SYM cord-010119-t1x9gknd 2843 34 1.6 1.6 CD cord-010119-t1x9gknd 2843 35 % % NN cord-010119-t1x9gknd 2843 36 and and CC cord-010119-t1x9gknd 2843 37 0.3 0.3 CD cord-010119-t1x9gknd 2843 38 - - SYM cord-010119-t1x9gknd 2843 39 1.4 1.4 CD cord-010119-t1x9gknd 2843 40 % % NN cord-010119-t1x9gknd 2843 41 , , , cord-010119-t1x9gknd 2843 42 respectively respectively RB cord-010119-t1x9gknd 2843 43 . . . cord-010119-t1x9gknd 2844 1 Since since IN cord-010119-t1x9gknd 2844 2 the the DT cord-010119-t1x9gknd 2844 3 implementation implementation NN cord-010119-t1x9gknd 2844 4 of of IN cord-010119-t1x9gknd 2844 5 College College NNP cord-010119-t1x9gknd 2844 6 of of IN cord-010119-t1x9gknd 2844 7 American American NNP cord-010119-t1x9gknd 2844 8 Pathologists Pathologists NNPS cord-010119-t1x9gknd 2844 9 ( ( -LRB- cord-010119-t1x9gknd 2844 10 CAP cap NN cord-010119-t1x9gknd 2844 11 ) ) -RRB- cord-010119-t1x9gknd 2844 12 requirements requirement NNS cord-010119-t1x9gknd 2844 13 for for IN cord-010119-t1x9gknd 2844 14 ABO/ ABO/ NNP cord-010119-t1x9gknd 2844 15 Rh Rh NNP cord-010119-t1x9gknd 2844 16 confirmation confirmation NN cord-010119-t1x9gknd 2844 17 , , , cord-010119-t1x9gknd 2844 18 approximately approximately RB cord-010119-t1x9gknd 2844 19 15 15 CD cord-010119-t1x9gknd 2844 20 % % NN cord-010119-t1x9gknd 2844 21 of of IN cord-010119-t1x9gknd 2844 22 patients patient NNS cord-010119-t1x9gknd 2844 23 who who WP cord-010119-t1x9gknd 2844 24 receive receive VBP cord-010119-t1x9gknd 2844 25 a a DT cord-010119-t1x9gknd 2844 26 transfusion transfusion NN cord-010119-t1x9gknd 2844 27 in in IN cord-010119-t1x9gknd 2844 28 our -PRON- PRP$ cord-010119-t1x9gknd 2844 29 hospital hospital NN cord-010119-t1x9gknd 2844 30 required require VBD cord-010119-t1x9gknd 2844 31 a a DT cord-010119-t1x9gknd 2844 32 second second JJ cord-010119-t1x9gknd 2844 33 ABO ABO NNP cord-010119-t1x9gknd 2844 34 / / SYM cord-010119-t1x9gknd 2844 35 Rh Rh NNP cord-010119-t1x9gknd 2844 36 specimen specimen NN cord-010119-t1x9gknd 2844 37 to to TO cord-010119-t1x9gknd 2844 38 be be VB cord-010119-t1x9gknd 2844 39 drawn draw VBN cord-010119-t1x9gknd 2844 40 ; ; : cord-010119-t1x9gknd 2844 41 however however RB cord-010119-t1x9gknd 2844 42 , , , cord-010119-t1x9gknd 2844 43 limited limited JJ cord-010119-t1x9gknd 2844 44 data datum NNS cord-010119-t1x9gknd 2844 45 are be VBP cord-010119-t1x9gknd 2844 46 available available JJ cord-010119-t1x9gknd 2844 47 regarding regard VBG cord-010119-t1x9gknd 2844 48 the the DT cord-010119-t1x9gknd 2844 49 impact impact NN cord-010119-t1x9gknd 2844 50 of of IN cord-010119-t1x9gknd 2844 51 this this DT cord-010119-t1x9gknd 2844 52 new new JJ cord-010119-t1x9gknd 2844 53 requirement requirement NN cord-010119-t1x9gknd 2844 54 on on IN cord-010119-t1x9gknd 2844 55 patients patient NNS cord-010119-t1x9gknd 2844 56 preparing prepare VBG cord-010119-t1x9gknd 2844 57 to to TO cord-010119-t1x9gknd 2844 58 undergo undergo VB cord-010119-t1x9gknd 2844 59 outpatient outpatient NN cord-010119-t1x9gknd 2844 60 surgery surgery NN cord-010119-t1x9gknd 2844 61 that that WDT cord-010119-t1x9gknd 2844 62 currently currently RB cord-010119-t1x9gknd 2844 63 require require VBP cord-010119-t1x9gknd 2844 64 preoperative preoperative JJ cord-010119-t1x9gknd 2844 65 Type type NN cord-010119-t1x9gknd 2844 66 & & CC cord-010119-t1x9gknd 2844 67 Screen Screen NNP cord-010119-t1x9gknd 2844 68 ( ( -LRB- cord-010119-t1x9gknd 2844 69 T&S T&S NNP cord-010119-t1x9gknd 2844 70 ) ) -RRB- cord-010119-t1x9gknd 2844 71 . . . cord-010119-t1x9gknd 2845 1 The the DT cord-010119-t1x9gknd 2845 2 primary primary JJ cord-010119-t1x9gknd 2845 3 objective objective NN cord-010119-t1x9gknd 2845 4 of of IN cord-010119-t1x9gknd 2845 5 our -PRON- PRP$ cord-010119-t1x9gknd 2845 6 study study NN cord-010119-t1x9gknd 2845 7 was be VBD cord-010119-t1x9gknd 2845 8 to to TO cord-010119-t1x9gknd 2845 9 assess assess VB cord-010119-t1x9gknd 2845 10 the the DT cord-010119-t1x9gknd 2845 11 rate rate NN cord-010119-t1x9gknd 2845 12 of of IN cord-010119-t1x9gknd 2845 13 ABO ABO NNP cord-010119-t1x9gknd 2845 14 / / SYM cord-010119-t1x9gknd 2845 15 Rh Rh NNP cord-010119-t1x9gknd 2845 16 confirmation confirmation NN cord-010119-t1x9gknd 2845 17 in in IN cord-010119-t1x9gknd 2845 18 women woman NNS cord-010119-t1x9gknd 2845 19 who who WP cord-010119-t1x9gknd 2845 20 underwent undergo VBD cord-010119-t1x9gknd 2845 21 outpatient outpatient JJ cord-010119-t1x9gknd 2845 22 POP pop NN cord-010119-t1x9gknd 2845 23 surgery surgery NN cord-010119-t1x9gknd 2845 24 . . . cord-010119-t1x9gknd 2846 1 Study Study NNP cord-010119-t1x9gknd 2846 2 Design Design NNP cord-010119-t1x9gknd 2846 3 / / SYM cord-010119-t1x9gknd 2846 4 Method method NN cord-010119-t1x9gknd 2846 5 : : : cord-010119-t1x9gknd 2846 6 This this DT cord-010119-t1x9gknd 2846 7 was be VBD cord-010119-t1x9gknd 2846 8 a a DT cord-010119-t1x9gknd 2846 9 planned planned JJ cord-010119-t1x9gknd 2846 10 secondary secondary JJ cord-010119-t1x9gknd 2846 11 analysis analysis NN cord-010119-t1x9gknd 2846 12 of of IN cord-010119-t1x9gknd 2846 13 a a DT cord-010119-t1x9gknd 2846 14 retrospective retrospective JJ cord-010119-t1x9gknd 2846 15 cohort cohort NN cord-010119-t1x9gknd 2846 16 study study NN cord-010119-t1x9gknd 2846 17 of of IN cord-010119-t1x9gknd 2846 18 consecutive consecutive JJ cord-010119-t1x9gknd 2846 19 patients patient NNS cord-010119-t1x9gknd 2846 20 undergoing undergo VBG cord-010119-t1x9gknd 2846 21 POP pop VB cord-010119-t1x9gknd 2846 22 surgical surgical JJ cord-010119-t1x9gknd 2846 23 repair repair NN cord-010119-t1x9gknd 2846 24 from from IN cord-010119-t1x9gknd 2846 25 May May NNP cord-010119-t1x9gknd 2846 26 2015 2015 CD cord-010119-t1x9gknd 2846 27 -May -May NNP cord-010119-t1x9gknd 2846 28 2016 2016 CD cord-010119-t1x9gknd 2846 29 in in IN cord-010119-t1x9gknd 2846 30 our -PRON- PRP$ cord-010119-t1x9gknd 2846 31 academic academic JJ cord-010119-t1x9gknd 2846 32 tertiary tertiary JJ cord-010119-t1x9gknd 2846 33 care care NN cord-010119-t1x9gknd 2846 34 institution institution NN cord-010119-t1x9gknd 2846 35 . . . cord-010119-t1x9gknd 2847 1 Among among IN cord-010119-t1x9gknd 2847 2 this this DT cord-010119-t1x9gknd 2847 3 sample sample NN cord-010119-t1x9gknd 2847 4 , , , cord-010119-t1x9gknd 2847 5 patients patient NNS cord-010119-t1x9gknd 2847 6 were be VBD cord-010119-t1x9gknd 2847 7 excluded exclude VBN cord-010119-t1x9gknd 2847 8 if if IN cord-010119-t1x9gknd 2847 9 their -PRON- PRP$ cord-010119-t1x9gknd 2847 10 first first JJ cord-010119-t1x9gknd 2847 11 T&S T&S NNP cord-010119-t1x9gknd 2847 12 was be VBD cord-010119-t1x9gknd 2847 13 drawn draw VBN cord-010119-t1x9gknd 2847 14 before before IN cord-010119-t1x9gknd 2847 15 our -PRON- PRP$ cord-010119-t1x9gknd 2847 16 institution institution NN cord-010119-t1x9gknd 2847 17 implemented implement VBD cord-010119-t1x9gknd 2847 18 the the DT cord-010119-t1x9gknd 2847 19 ABO ABO NNP cord-010119-t1x9gknd 2847 20 / / SYM cord-010119-t1x9gknd 2847 21 Rh Rh NNP cord-010119-t1x9gknd 2847 22 confirmation confirmation NN cord-010119-t1x9gknd 2847 23 requirement requirement NN cord-010119-t1x9gknd 2847 24 . . . cord-010119-t1x9gknd 2848 1 Fisher Fisher NNP cord-010119-t1x9gknd 2848 2 's 's POS cord-010119-t1x9gknd 2848 3 Exact Exact NNP cord-010119-t1x9gknd 2848 4 Test Test NNP cord-010119-t1x9gknd 2848 5 was be VBD cord-010119-t1x9gknd 2848 6 used use VBN cord-010119-t1x9gknd 2848 7 , , , cord-010119-t1x9gknd 2848 8 and and CC cord-010119-t1x9gknd 2848 9 statistical statistical JJ cord-010119-t1x9gknd 2848 10 significance significance NN cord-010119-t1x9gknd 2848 11 was be VBD cord-010119-t1x9gknd 2848 12 defined define VBN cord-010119-t1x9gknd 2848 13 as as IN cord-010119-t1x9gknd 2848 14 p<0.05 p<0.05 CD cord-010119-t1x9gknd 2848 15 . . . cord-010119-t1x9gknd 2849 1 Results/ Results/ . cord-010119-t1x9gknd 2850 1 Finding find VBG cord-010119-t1x9gknd 2851 1 : : : cord-010119-t1x9gknd 2851 2 We -PRON- PRP cord-010119-t1x9gknd 2851 3 identified identify VBD cord-010119-t1x9gknd 2851 4 66 66 CD cord-010119-t1x9gknd 2851 5 patients patient NNS cord-010119-t1x9gknd 2851 6 for for IN cord-010119-t1x9gknd 2851 7 analysis analysis NN cord-010119-t1x9gknd 2851 8 , , , cord-010119-t1x9gknd 2851 9 of of IN cord-010119-t1x9gknd 2851 10 whom whom WP cord-010119-t1x9gknd 2851 11 65 65 CD cord-010119-t1x9gknd 2851 12 ( ( -LRB- cord-010119-t1x9gknd 2851 13 98.5 98.5 CD cord-010119-t1x9gknd 2851 14 % % NN cord-010119-t1x9gknd 2851 15 ) ) -RRB- cord-010119-t1x9gknd 2851 16 had have VBD cord-010119-t1x9gknd 2851 17 a a DT cord-010119-t1x9gknd 2851 18 preoperative preoperative JJ cord-010119-t1x9gknd 2851 19 T&S t&s NN cord-010119-t1x9gknd 2851 20 ordered order VBN cord-010119-t1x9gknd 2851 21 . . . cord-010119-t1x9gknd 2852 1 Two two CD cord-010119-t1x9gknd 2852 2 ( ( -LRB- cord-010119-t1x9gknd 2852 3 3.1 3.1 CD cord-010119-t1x9gknd 2852 4 % % NN cord-010119-t1x9gknd 2852 5 ) ) -RRB- cord-010119-t1x9gknd 2852 6 of of IN cord-010119-t1x9gknd 2852 7 these these DT cord-010119-t1x9gknd 2852 8 65 65 CD cord-010119-t1x9gknd 2852 9 patients patient NNS cord-010119-t1x9gknd 2852 10 had have VBD cord-010119-t1x9gknd 2852 11 positive positive JJ cord-010119-t1x9gknd 2852 12 antibody antibody NN cord-010119-t1x9gknd 2852 13 screens screen NNS cord-010119-t1x9gknd 2852 14 ; ; : cord-010119-t1x9gknd 2852 15 one one CD cord-010119-t1x9gknd 2852 16 patient patient NN cord-010119-t1x9gknd 2852 17 had have VBD cord-010119-t1x9gknd 2852 18 an an DT cord-010119-t1x9gknd 2852 19 anti anti JJ cord-010119-t1x9gknd 2852 20 - - JJ cord-010119-t1x9gknd 2852 21 K k JJ cord-010119-t1x9gknd 2852 22 and and CC cord-010119-t1x9gknd 2852 23 one one PRP cord-010119-t1x9gknd 2852 24 had have VBD cord-010119-t1x9gknd 2852 25 a a DT cord-010119-t1x9gknd 2852 26 warm warm RB cord-010119-t1x9gknd 2852 27 - - HYPH cord-010119-t1x9gknd 2852 28 reacting react VBG cord-010119-t1x9gknd 2852 29 autoantibody autoantibody NN cord-010119-t1x9gknd 2852 30 . . . cord-010119-t1x9gknd 2853 1 Fifty fifty CD cord-010119-t1x9gknd 2853 2 - - HYPH cord-010119-t1x9gknd 2853 3 nine nine CD cord-010119-t1x9gknd 2853 4 ( ( -LRB- cord-010119-t1x9gknd 2853 5 90.8 90.8 CD cord-010119-t1x9gknd 2853 6 % % NN cord-010119-t1x9gknd 2853 7 ) ) -RRB- cord-010119-t1x9gknd 2853 8 of of IN cord-010119-t1x9gknd 2853 9 the the DT cord-010119-t1x9gknd 2853 10 65 65 CD cord-010119-t1x9gknd 2853 11 patients patient NNS cord-010119-t1x9gknd 2853 12 required require VBD cord-010119-t1x9gknd 2853 13 a a DT cord-010119-t1x9gknd 2853 14 second second JJ cord-010119-t1x9gknd 2853 15 ABO ABO NNP cord-010119-t1x9gknd 2853 16 / / SYM cord-010119-t1x9gknd 2853 17 Rh Rh NNP cord-010119-t1x9gknd 2853 18 specimen specimen NN cord-010119-t1x9gknd 2853 19 per per IN cord-010119-t1x9gknd 2853 20 hospital hospital NN cord-010119-t1x9gknd 2853 21 protocol protocol NN cord-010119-t1x9gknd 2853 22 ; ; . cord-010119-t1x9gknd 2854 1 51 51 CD cord-010119-t1x9gknd 2854 2 ( ( -LRB- cord-010119-t1x9gknd 2854 3 86.4 86.4 CD cord-010119-t1x9gknd 2854 4 % % NN cord-010119-t1x9gknd 2854 5 ) ) -RRB- cord-010119-t1x9gknd 2854 6 of of IN cord-010119-t1x9gknd 2854 7 these these DT cord-010119-t1x9gknd 2854 8 actually actually RB cord-010119-t1x9gknd 2854 9 had have VBD cord-010119-t1x9gknd 2854 10 a a DT cord-010119-t1x9gknd 2854 11 second second JJ cord-010119-t1x9gknd 2854 12 specimen specimen NN cord-010119-t1x9gknd 2854 13 drawn draw VBN cord-010119-t1x9gknd 2854 14 . . . cord-010119-t1x9gknd 2855 1 In in IN cord-010119-t1x9gknd 2855 2 patients patient NNS cord-010119-t1x9gknd 2855 3 for for IN cord-010119-t1x9gknd 2855 4 whom whom WP cord-010119-t1x9gknd 2855 5 ABO ABO NNP cord-010119-t1x9gknd 2855 6 / / SYM cord-010119-t1x9gknd 2855 7 Rh Rh NNP cord-010119-t1x9gknd 2855 8 confirmation confirmation NN cord-010119-t1x9gknd 2855 9 was be VBD cord-010119-t1x9gknd 2855 10 indicated indicate VBN cord-010119-t1x9gknd 2855 11 , , , cord-010119-t1x9gknd 2855 12 there there EX cord-010119-t1x9gknd 2855 13 were be VBD cord-010119-t1x9gknd 2855 14 no no DT cord-010119-t1x9gknd 2855 15 differences difference NNS cord-010119-t1x9gknd 2855 16 between between IN cord-010119-t1x9gknd 2855 17 those those DT cord-010119-t1x9gknd 2855 18 who who WP cord-010119-t1x9gknd 2855 19 did do VBD cord-010119-t1x9gknd 2855 20 and and CC cord-010119-t1x9gknd 2855 21 did do VBD cord-010119-t1x9gknd 2855 22 not not RB cord-010119-t1x9gknd 2855 23 have have VB cord-010119-t1x9gknd 2855 24 ABO ABO NNP cord-010119-t1x9gknd 2855 25 / / SYM cord-010119-t1x9gknd 2855 26 Rh Rh NNP cord-010119-t1x9gknd 2855 27 confirmed confirm VBD cord-010119-t1x9gknd 2855 28 when when WRB cord-010119-t1x9gknd 2855 29 comparing compare VBG cord-010119-t1x9gknd 2855 30 age age NN cord-010119-t1x9gknd 2855 31 , , , cord-010119-t1x9gknd 2855 32 body body NN cord-010119-t1x9gknd 2855 33 mass mass NN cord-010119-t1x9gknd 2855 34 index index NN cord-010119-t1x9gknd 2855 35 ( ( -LRB- cord-010119-t1x9gknd 2855 36 BMI BMI NNP cord-010119-t1x9gknd 2855 37 ) ) -RRB- cord-010119-t1x9gknd 2855 38 , , , cord-010119-t1x9gknd 2855 39 pre pre JJ cord-010119-t1x9gknd 2855 40 - - JJ cord-010119-t1x9gknd 2855 41 operative operative JJ cord-010119-t1x9gknd 2855 42 hemoglobin hemoglobin NN cord-010119-t1x9gknd 2855 43 ( ( -LRB- cord-010119-t1x9gknd 2855 44 Hgb Hgb NNP cord-010119-t1x9gknd 2855 45 ) ) -RRB- cord-010119-t1x9gknd 2855 46 , , , cord-010119-t1x9gknd 2855 47 or or CC cord-010119-t1x9gknd 2855 48 surgical surgical JJ cord-010119-t1x9gknd 2855 49 approach approach NN cord-010119-t1x9gknd 2855 50 ( ( -LRB- cord-010119-t1x9gknd 2855 51 Table table NN cord-010119-t1x9gknd 2855 52 1 1 CD cord-010119-t1x9gknd 2855 53 ) ) -RRB- cord-010119-t1x9gknd 2855 54 . . . cord-010119-t1x9gknd 2856 1 No no UH cord-010119-t1x9gknd 2857 1 ABO ABO NNP cord-010119-t1x9gknd 2857 2 / / SYM cord-010119-t1x9gknd 2857 3 Rh Rh NNP cord-010119-t1x9gknd 2857 4 discrepancies discrepancy NNS cord-010119-t1x9gknd 2857 5 were be VBD cord-010119-t1x9gknd 2857 6 identified identify VBN cord-010119-t1x9gknd 2857 7 . . . cord-010119-t1x9gknd 2858 1 One one CD cord-010119-t1x9gknd 2858 2 patient patient NN cord-010119-t1x9gknd 2858 3 received receive VBD cord-010119-t1x9gknd 2858 4 1 1 CD cord-010119-t1x9gknd 2858 5 unit unit NN cord-010119-t1x9gknd 2858 6 of of IN cord-010119-t1x9gknd 2858 7 red red JJ cord-010119-t1x9gknd 2858 8 cells cell NNS cord-010119-t1x9gknd 2858 9 after after IN cord-010119-t1x9gknd 2858 10 abdominal abdominal JJ cord-010119-t1x9gknd 2858 11 POP pop NN cord-010119-t1x9gknd 2858 12 surgery surgery NN cord-010119-t1x9gknd 2858 13 . . . cord-010119-t1x9gknd 2859 1 Conclusion conclusion NN cord-010119-t1x9gknd 2859 2 : : : cord-010119-t1x9gknd 2860 1 The the DT cord-010119-t1x9gknd 2860 2 rate rate NN cord-010119-t1x9gknd 2860 3 of of IN cord-010119-t1x9gknd 2860 4 requiring require VBG cord-010119-t1x9gknd 2860 5 ABO ABO NNP cord-010119-t1x9gknd 2860 6 / / SYM cord-010119-t1x9gknd 2860 7 Rh Rh NNP cord-010119-t1x9gknd 2860 8 confirmation confirmation NN cord-010119-t1x9gknd 2860 9 before before IN cord-010119-t1x9gknd 2860 10 POP pop NN cord-010119-t1x9gknd 2860 11 surgery surgery NN cord-010119-t1x9gknd 2860 12 was be VBD cord-010119-t1x9gknd 2860 13 markedly markedly RB cord-010119-t1x9gknd 2860 14 higher high JJR cord-010119-t1x9gknd 2860 15 than than IN cord-010119-t1x9gknd 2860 16 that that DT cord-010119-t1x9gknd 2860 17 seen see VBN cord-010119-t1x9gknd 2860 18 in in IN cord-010119-t1x9gknd 2860 19 all all DT cord-010119-t1x9gknd 2860 20 patients patient NNS cord-010119-t1x9gknd 2860 21 receiving receive VBG cord-010119-t1x9gknd 2860 22 transfusions transfusion NNS cord-010119-t1x9gknd 2860 23 at at IN cord-010119-t1x9gknd 2860 24 our -PRON- PRP$ cord-010119-t1x9gknd 2860 25 institution institution NN cord-010119-t1x9gknd 2860 26 ( ( -LRB- cord-010119-t1x9gknd 2860 27 90.8 90.8 CD cord-010119-t1x9gknd 2860 28 % % NN cord-010119-t1x9gknd 2860 29 vs. vs. CC cord-010119-t1x9gknd 2860 30 15 15 CD cord-010119-t1x9gknd 2860 31 % % NN cord-010119-t1x9gknd 2860 32 , , , cord-010119-t1x9gknd 2860 33 respectively respectively RB cord-010119-t1x9gknd 2860 34 ) ) -RRB- cord-010119-t1x9gknd 2860 35 . . . cord-010119-t1x9gknd 2861 1 Because because IN cord-010119-t1x9gknd 2861 2 the the DT cord-010119-t1x9gknd 2861 3 vast vast JJ cord-010119-t1x9gknd 2861 4 majority majority NN cord-010119-t1x9gknd 2861 5 of of IN cord-010119-t1x9gknd 2861 6 women woman NNS cord-010119-t1x9gknd 2861 7 undergoing undergo VBG cord-010119-t1x9gknd 2861 8 vaginal vaginal JJ cord-010119-t1x9gknd 2861 9 or or CC cord-010119-t1x9gknd 2861 10 robotic robotic JJ cord-010119-t1x9gknd 2861 11 POP pop NN cord-010119-t1x9gknd 2861 12 surgery surgery NN cord-010119-t1x9gknd 2861 13 are be VBP cord-010119-t1x9gknd 2861 14 not not RB cord-010119-t1x9gknd 2861 15 transfused transfuse VBN cord-010119-t1x9gknd 2861 16 perioperatively perioperatively NN cord-010119-t1x9gknd 2861 17 , , , cord-010119-t1x9gknd 2861 18 hospital hospital NN cord-010119-t1x9gknd 2861 19 transfusion transfusion NN cord-010119-t1x9gknd 2861 20 services service NNS cord-010119-t1x9gknd 2861 21 should should MD cord-010119-t1x9gknd 2861 22 consider consider VB cord-010119-t1x9gknd 2861 23 eliminating eliminate VBG cord-010119-t1x9gknd 2861 24 routine routine JJ cord-010119-t1x9gknd 2861 25 pre pre JJ cord-010119-t1x9gknd 2861 26 - - JJ cord-010119-t1x9gknd 2861 27 operative operative JJ cord-010119-t1x9gknd 2861 28 T&S t&s NN cord-010119-t1x9gknd 2861 29 for for IN cord-010119-t1x9gknd 2861 30 this this DT cord-010119-t1x9gknd 2861 31 low low JJ cord-010119-t1x9gknd 2861 32 - - HYPH cord-010119-t1x9gknd 2861 33 risk risk NN cord-010119-t1x9gknd 2861 34 population population NN cord-010119-t1x9gknd 2861 35 in in IN cord-010119-t1x9gknd 2861 36 the the DT cord-010119-t1x9gknd 2861 37 maximum maximum JJ cord-010119-t1x9gknd 2861 38 surgical surgical JJ cord-010119-t1x9gknd 2861 39 blood blood NN cord-010119-t1x9gknd 2861 40 ordering ordering NN cord-010119-t1x9gknd 2861 41 schedule schedule NN cord-010119-t1x9gknd 2861 42 , , , cord-010119-t1x9gknd 2861 43 avoiding avoid VBG cord-010119-t1x9gknd 2861 44 this this DT cord-010119-t1x9gknd 2861 45 unneeded unneeded JJ cord-010119-t1x9gknd 2861 46 test test NN cord-010119-t1x9gknd 2861 47 and and CC cord-010119-t1x9gknd 2861 48 subsequent subsequent JJ cord-010119-t1x9gknd 2861 49 ABO ABO NNP cord-010119-t1x9gknd 2861 50 / / SYM cord-010119-t1x9gknd 2861 51 Rh Rh NNP cord-010119-t1x9gknd 2861 52 confirmation confirmation NN cord-010119-t1x9gknd 2861 53 . . . cord-010119-t1x9gknd 2862 1 Volume volume NN cord-010119-t1x9gknd 2862 2 Reduction Reduction NNP cord-010119-t1x9gknd 2862 3 of of IN cord-010119-t1x9gknd 2862 4 Red Red NNP cord-010119-t1x9gknd 2862 5 Cells Cells NNPS cord-010119-t1x9gknd 2862 6 to to TO cord-010119-t1x9gknd 2862 7 Reduce reduce VB cord-010119-t1x9gknd 2862 8 Transfusion transfusion NN cord-010119-t1x9gknd 2862 9 - - HYPH cord-010119-t1x9gknd 2862 10 Associated Associated NNP cord-010119-t1x9gknd 2862 11 Adverse adverse JJ cord-010119-t1x9gknd 2862 12 Events event NNS cord-010119-t1x9gknd 2862 13 Related relate VBN cord-010119-t1x9gknd 2862 14 to to IN cord-010119-t1x9gknd 2862 15 Hyperkalemia Hyperkalemia NNP cord-010119-t1x9gknd 2862 16 Maressa Maressa NNP cord-010119-t1x9gknd 2862 17 T T NNP cord-010119-t1x9gknd 2862 18 Pollen pollen NN cord-010119-t1x9gknd 2863 1 * * NFP cord-010119-t1x9gknd 2863 2 , , , cord-010119-t1x9gknd 2863 3 Laura Laura NNP cord-010119-t1x9gknd 2863 4 Knicks Knicks NNP cord-010119-t1x9gknd 2863 5 , , , cord-010119-t1x9gknd 2863 6 Linda Linda NNP cord-010119-t1x9gknd 2863 7 Van Van NNP cord-010119-t1x9gknd 2863 8 Tol Tol NNP cord-010119-t1x9gknd 2863 9 and and CC cord-010119-t1x9gknd 2863 10 C. C. NNP cord-010119-t1x9gknd 2863 11 Michael Michael NNP cord-010119-t1x9gknd 2863 12 Knudson Knudson NNP cord-010119-t1x9gknd 2863 13 . . . cord-010119-t1x9gknd 2864 1 Background Background NNP cord-010119-t1x9gknd 2864 2 / / SYM cord-010119-t1x9gknd 2864 3 Case Case NNP cord-010119-t1x9gknd 2864 4 Studies Studies NNPS cord-010119-t1x9gknd 2864 5 : : : cord-010119-t1x9gknd 2864 6 One one CD cord-010119-t1x9gknd 2864 7 attribute attribute NN cord-010119-t1x9gknd 2864 8 of of IN cord-010119-t1x9gknd 2864 9 older old JJR cord-010119-t1x9gknd 2864 10 blood blood NN cord-010119-t1x9gknd 2864 11 is be VBZ cord-010119-t1x9gknd 2864 12 an an DT cord-010119-t1x9gknd 2864 13 increase increase NN cord-010119-t1x9gknd 2864 14 in in IN cord-010119-t1x9gknd 2864 15 supernatant supernatant JJ cord-010119-t1x9gknd 2864 16 potassium potassium NN cord-010119-t1x9gknd 2864 17 level level NN cord-010119-t1x9gknd 2864 18 which which WDT cord-010119-t1x9gknd 2864 19 can can MD cord-010119-t1x9gknd 2864 20 contribute contribute VB cord-010119-t1x9gknd 2864 21 to to IN cord-010119-t1x9gknd 2864 22 transient transient JJ cord-010119-t1x9gknd 2864 23 hyperkalemia hyperkalemia NN cord-010119-t1x9gknd 2864 24 . . . cord-010119-t1x9gknd 2865 1 This this DT cord-010119-t1x9gknd 2865 2 problem problem NN cord-010119-t1x9gknd 2865 3 is be VBZ cord-010119-t1x9gknd 2865 4 exacerbated exacerbate VBN cord-010119-t1x9gknd 2865 5 in in IN cord-010119-t1x9gknd 2865 6 conditions condition NNS cord-010119-t1x9gknd 2865 7 of of IN cord-010119-t1x9gknd 2865 8 massive massive JJ cord-010119-t1x9gknd 2865 9 transfusion transfusion NN cord-010119-t1x9gknd 2865 10 and and CC cord-010119-t1x9gknd 2865 11 in in IN cord-010119-t1x9gknd 2865 12 patients patient NNS cord-010119-t1x9gknd 2865 13 with with IN cord-010119-t1x9gknd 2865 14 renal renal JJ cord-010119-t1x9gknd 2865 15 failure failure NN cord-010119-t1x9gknd 2865 16 . . . cord-010119-t1x9gknd 2866 1 Washing washing NN cord-010119-t1x9gknd 2866 2 RBCs rbc NNS cord-010119-t1x9gknd 2866 3 can can MD cord-010119-t1x9gknd 2866 4 effectively effectively RB cord-010119-t1x9gknd 2866 5 remove remove VB cord-010119-t1x9gknd 2866 6 free free JJ cord-010119-t1x9gknd 2866 7 potassium potassium NN cord-010119-t1x9gknd 2866 8 but but CC cord-010119-t1x9gknd 2866 9 is be VBZ cord-010119-t1x9gknd 2866 10 time time NN cord-010119-t1x9gknd 2866 11 consuming consume VBG cord-010119-t1x9gknd 2866 12 and and CC cord-010119-t1x9gknd 2866 13 can can MD cord-010119-t1x9gknd 2866 14 often often RB cord-010119-t1x9gknd 2866 15 only only RB cord-010119-t1x9gknd 2866 16 be be VB cord-010119-t1x9gknd 2866 17 performed perform VBN cord-010119-t1x9gknd 2866 18 on on IN cord-010119-t1x9gknd 2866 19 one one CD cord-010119-t1x9gknd 2866 20 unit unit NN cord-010119-t1x9gknd 2866 21 at at IN cord-010119-t1x9gknd 2866 22 a a DT cord-010119-t1x9gknd 2866 23 time time NN cord-010119-t1x9gknd 2866 24 . . . cord-010119-t1x9gknd 2867 1 Here here RB cord-010119-t1x9gknd 2867 2 , , , cord-010119-t1x9gknd 2867 3 we -PRON- PRP cord-010119-t1x9gknd 2867 4 estimate estimate VBP cord-010119-t1x9gknd 2867 5 the the DT cord-010119-t1x9gknd 2867 6 amount amount NN cord-010119-t1x9gknd 2867 7 of of IN cord-010119-t1x9gknd 2867 8 potassium potassium NN cord-010119-t1x9gknd 2867 9 that that WDT cord-010119-t1x9gknd 2867 10 is be VBZ cord-010119-t1x9gknd 2867 11 removed remove VBN cord-010119-t1x9gknd 2867 12 by by IN cord-010119-t1x9gknd 2867 13 volume volume NN cord-010119-t1x9gknd 2867 14 reduction reduction NN cord-010119-t1x9gknd 2867 15 of of IN cord-010119-t1x9gknd 2867 16 red red JJ cord-010119-t1x9gknd 2867 17 cell cell NN cord-010119-t1x9gknd 2867 18 units unit NNS cord-010119-t1x9gknd 2867 19 . . . cord-010119-t1x9gknd 2868 1 We -PRON- PRP cord-010119-t1x9gknd 2868 2 also also RB cord-010119-t1x9gknd 2868 3 examined examine VBD cord-010119-t1x9gknd 2868 4 whether whether IN cord-010119-t1x9gknd 2868 5 this this DT cord-010119-t1x9gknd 2868 6 technique technique NN cord-010119-t1x9gknd 2868 7 would would MD cord-010119-t1x9gknd 2868 8 be be VB cord-010119-t1x9gknd 2868 9 feasible feasible JJ cord-010119-t1x9gknd 2868 10 in in IN cord-010119-t1x9gknd 2868 11 the the DT cord-010119-t1x9gknd 2868 12 setting setting NN cord-010119-t1x9gknd 2868 13 of of IN cord-010119-t1x9gknd 2868 14 massive massive JJ cord-010119-t1x9gknd 2868 15 transfusion transfusion NN cord-010119-t1x9gknd 2868 16 in in IN cord-010119-t1x9gknd 2868 17 a a DT cord-010119-t1x9gknd 2868 18 patient patient NN cord-010119-t1x9gknd 2868 19 with with IN cord-010119-t1x9gknd 2868 20 hyperkalemia hyperkalemia NN cord-010119-t1x9gknd 2868 21 . . . cord-010119-t1x9gknd 2869 1 Study Study NNP cord-010119-t1x9gknd 2869 2 Design Design NNP cord-010119-t1x9gknd 2869 3 / / SYM cord-010119-t1x9gknd 2869 4 Method method NN cord-010119-t1x9gknd 2869 5 : : : cord-010119-t1x9gknd 2870 1 Expired expire VBN cord-010119-t1x9gknd 2870 2 or or CC cord-010119-t1x9gknd 2870 3 over over IN cord-010119-t1x9gknd 2870 4 temperature temperature NN cord-010119-t1x9gknd 2870 5 units unit NNS cord-010119-t1x9gknd 2870 6 ( ( -LRB- cord-010119-t1x9gknd 2870 7 n527 n527 NNP cord-010119-t1x9gknd 2870 8 ) ) -RRB- cord-010119-t1x9gknd 2870 9 that that WDT cord-010119-t1x9gknd 2870 10 had have VBD cord-010119-t1x9gknd 2870 11 been be VBN cord-010119-t1x9gknd 2870 12 removed remove VBN cord-010119-t1x9gknd 2870 13 from from IN cord-010119-t1x9gknd 2870 14 inventory inventory NN cord-010119-t1x9gknd 2870 15 were be VBD cord-010119-t1x9gknd 2870 16 utilized utilize VBN cord-010119-t1x9gknd 2870 17 for for IN cord-010119-t1x9gknd 2870 18 these these DT cord-010119-t1x9gknd 2870 19 studies study NNS cord-010119-t1x9gknd 2870 20 . . . cord-010119-t1x9gknd 2871 1 Each each DT cord-010119-t1x9gknd 2871 2 unit unit NN cord-010119-t1x9gknd 2871 3 was be VBD cord-010119-t1x9gknd 2871 4 weighed weigh VBN cord-010119-t1x9gknd 2871 5 and and CC cord-010119-t1x9gknd 2871 6 a a DT cord-010119-t1x9gknd 2871 7 volume volume NN cord-010119-t1x9gknd 2871 8 reduction reduction NN cord-010119-t1x9gknd 2871 9 procedure procedure NN cord-010119-t1x9gknd 2871 10 was be VBD cord-010119-t1x9gknd 2871 11 performed perform VBN cord-010119-t1x9gknd 2871 12 . . . cord-010119-t1x9gknd 2872 1 The the DT cord-010119-t1x9gknd 2872 2 supernatant supernatant NN cord-010119-t1x9gknd 2872 3 was be VBD cord-010119-t1x9gknd 2872 4 weighed weigh VBN cord-010119-t1x9gknd 2872 5 and and CC cord-010119-t1x9gknd 2872 6 the the DT cord-010119-t1x9gknd 2872 7 potassium potassium NN cord-010119-t1x9gknd 2872 8 of of IN cord-010119-t1x9gknd 2872 9 the the DT cord-010119-t1x9gknd 2872 10 supernatant supernatant NN cord-010119-t1x9gknd 2872 11 was be VBD cord-010119-t1x9gknd 2872 12 measured measure VBN cord-010119-t1x9gknd 2872 13 using use VBG cord-010119-t1x9gknd 2872 14 routine routine JJ cord-010119-t1x9gknd 2872 15 laboratory laboratory NN cord-010119-t1x9gknd 2872 16 assays assay NNS cord-010119-t1x9gknd 2872 17 . . . cord-010119-t1x9gknd 2873 1 For for IN cord-010119-t1x9gknd 2873 2 all all DT cord-010119-t1x9gknd 2873 3 formulas formula NNS cord-010119-t1x9gknd 2873 4 , , , cord-010119-t1x9gknd 2873 5 weight weight NN cord-010119-t1x9gknd 2873 6 was be VBD cord-010119-t1x9gknd 2873 7 converted convert VBN cord-010119-t1x9gknd 2873 8 to to IN cord-010119-t1x9gknd 2873 9 volume volume NN cord-010119-t1x9gknd 2873 10 using use VBG cord-010119-t1x9gknd 2873 11 a a DT cord-010119-t1x9gknd 2873 12 specific specific JJ cord-010119-t1x9gknd 2873 13 gravity gravity NN cord-010119-t1x9gknd 2873 14 of of IN cord-010119-t1x9gknd 2873 15 1.05 1.05 CD cord-010119-t1x9gknd 2873 16 g g NN cord-010119-t1x9gknd 2873 17 / / SYM cord-010119-t1x9gknd 2873 18 ml ml NN cord-010119-t1x9gknd 2873 19 . . . cord-010119-t1x9gknd 2874 1 The the DT cord-010119-t1x9gknd 2874 2 Hematocrit Hematocrit NNP cord-010119-t1x9gknd 2874 3 ( ( -LRB- cord-010119-t1x9gknd 2874 4 Hct Hct NNP cord-010119-t1x9gknd 2874 5 ) ) -RRB- cord-010119-t1x9gknd 2874 6 of of IN cord-010119-t1x9gknd 2874 7 the the DT cord-010119-t1x9gknd 2874 8 volume volume NN cord-010119-t1x9gknd 2874 9 reduced reduce VBN cord-010119-t1x9gknd 2874 10 RBC RBC NNP cord-010119-t1x9gknd 2874 11 was be VBD cord-010119-t1x9gknd 2874 12 measured measure VBN cord-010119-t1x9gknd 2874 13 using use VBG cord-010119-t1x9gknd 2874 14 a a DT cord-010119-t1x9gknd 2874 15 Sysmex Sysmex NNP cord-010119-t1x9gknd 2874 16 xs-1000i xs-1000i NNP cord-010119-t1x9gknd 2874 17 instrument instrument NN cord-010119-t1x9gknd 2874 18 . . . cord-010119-t1x9gknd 2875 1 The the DT cord-010119-t1x9gknd 2875 2 percentage percentage NN cord-010119-t1x9gknd 2875 3 of of IN cord-010119-t1x9gknd 2875 4 supernatant supernatant JJ cord-010119-t1x9gknd 2875 5 removed remove VBN cord-010119-t1x9gknd 2875 6 was be VBD cord-010119-t1x9gknd 2875 7 calculated calculate VBN cord-010119-t1x9gknd 2875 8 by by IN cord-010119-t1x9gknd 2875 9 dividing divide VBG cord-010119-t1x9gknd 2875 10 the the DT cord-010119-t1x9gknd 2875 11 residual residual JJ cord-010119-t1x9gknd 2875 12 supernatant supernatant NN cord-010119-t1x9gknd 2875 13 in in IN cord-010119-t1x9gknd 2875 14 the the DT cord-010119-t1x9gknd 2875 15 volume volume NN cord-010119-t1x9gknd 2875 16 reduced reduce VBN cord-010119-t1x9gknd 2875 17 unit unit NN cord-010119-t1x9gknd 2875 18 ( ( -LRB- cord-010119-t1x9gknd 2875 19 RBC RBC NNP cord-010119-t1x9gknd 2875 20 Hct Hct NNP cord-010119-t1x9gknd 2875 21 X X NNP cord-010119-t1x9gknd 2875 22 RBC RBC NNP cord-010119-t1x9gknd 2875 23 volume volume NN cord-010119-t1x9gknd 2875 24 ) ) -RRB- cord-010119-t1x9gknd 2875 25 by by IN cord-010119-t1x9gknd 2875 26 the the DT cord-010119-t1x9gknd 2875 27 total total JJ cord-010119-t1x9gknd 2875 28 supernatant supernatant JJ cord-010119-t1x9gknd 2875 29 prior prior RB cord-010119-t1x9gknd 2875 30 to to IN cord-010119-t1x9gknd 2875 31 the the DT cord-010119-t1x9gknd 2875 32 procedure procedure NN cord-010119-t1x9gknd 2875 33 ( ( -LRB- cord-010119-t1x9gknd 2875 34 residual residual JJ cord-010119-t1x9gknd 2875 35 supernatant supernatant NN cord-010119-t1x9gknd 2875 36 1 1 CD cord-010119-t1x9gknd 2875 37 removed remove VBN cord-010119-t1x9gknd 2875 38 supernatant supernatant NN cord-010119-t1x9gknd 2875 39 ) ) -RRB- cord-010119-t1x9gknd 2875 40 . . . cord-010119-t1x9gknd 2876 1 The the DT cord-010119-t1x9gknd 2876 2 remaining remain VBG cord-010119-t1x9gknd 2876 3 free free JJ cord-010119-t1x9gknd 2876 4 potassium potassium NN cord-010119-t1x9gknd 2876 5 ( ( -LRB- cord-010119-t1x9gknd 2876 6 mEq mEq NNS cord-010119-t1x9gknd 2876 7 ) ) -RRB- cord-010119-t1x9gknd 2876 8 was be VBD cord-010119-t1x9gknd 2876 9 calculated calculate VBN cord-010119-t1x9gknd 2876 10 as as IN cord-010119-t1x9gknd 2876 11 the the DT cord-010119-t1x9gknd 2876 12 ( ( -LRB- cord-010119-t1x9gknd 2876 13 concentration concentration NN cord-010119-t1x9gknd 2876 14 of of IN cord-010119-t1x9gknd 2876 15 potassium potassium NN cord-010119-t1x9gknd 2876 16 in in IN cord-010119-t1x9gknd 2876 17 the the DT cord-010119-t1x9gknd 2876 18 supernatant supernatant NN cord-010119-t1x9gknd 2876 19 ( ( -LRB- cord-010119-t1x9gknd 2876 20 mmol mmol NNP cord-010119-t1x9gknd 2876 21 / / SYM cord-010119-t1x9gknd 2876 22 L L NNP cord-010119-t1x9gknd 2876 23 ) ) -RRB- cord-010119-t1x9gknd 2876 24 x x : cord-010119-t1x9gknd 2876 25 the the DT cord-010119-t1x9gknd 2876 26 estimated estimate VBN cord-010119-t1x9gknd 2876 27 red red JJ cord-010119-t1x9gknd 2876 28 blood blood NN cord-010119-t1x9gknd 2876 29 cell cell NN cord-010119-t1x9gknd 2876 30 residual residual JJ cord-010119-t1x9gknd 2876 31 supernatant supernatant JJ cord-010119-t1x9gknd 2876 32 volume volume NN cord-010119-t1x9gknd 2876 33 . . . cord-010119-t1x9gknd 2877 1 To to TO cord-010119-t1x9gknd 2877 2 simulate simulate VB cord-010119-t1x9gknd 2877 3 the the DT cord-010119-t1x9gknd 2877 4 process process NN cord-010119-t1x9gknd 2877 5 that that WDT cord-010119-t1x9gknd 2877 6 would would MD cord-010119-t1x9gknd 2877 7 occur occur VB cord-010119-t1x9gknd 2877 8 in in IN cord-010119-t1x9gknd 2877 9 the the DT cord-010119-t1x9gknd 2877 10 setting setting NN cord-010119-t1x9gknd 2877 11 of of IN cord-010119-t1x9gknd 2877 12 a a DT cord-010119-t1x9gknd 2877 13 massive massive JJ cord-010119-t1x9gknd 2877 14 transfusion transfusion NN cord-010119-t1x9gknd 2877 15 protocol protocol NN cord-010119-t1x9gknd 2877 16 ( ( -LRB- cord-010119-t1x9gknd 2877 17 MTP MTP NNP cord-010119-t1x9gknd 2877 18 ) ) -RRB- cord-010119-t1x9gknd 2877 19 , , , cord-010119-t1x9gknd 2877 20 5 5 CD cord-010119-t1x9gknd 2877 21 units unit NNS cord-010119-t1x9gknd 2877 22 were be VBD cord-010119-t1x9gknd 2877 23 subjected subject VBN cord-010119-t1x9gknd 2877 24 to to IN cord-010119-t1x9gknd 2877 25 the the DT cord-010119-t1x9gknd 2877 26 volume volume NN cord-010119-t1x9gknd 2877 27 reduction reduction NN cord-010119-t1x9gknd 2877 28 while while IN cord-010119-t1x9gknd 2877 29 recording record VBG cord-010119-t1x9gknd 2877 30 the the DT cord-010119-t1x9gknd 2877 31 time time NN cord-010119-t1x9gknd 2877 32 needed need VBN cord-010119-t1x9gknd 2877 33 to to TO cord-010119-t1x9gknd 2877 34 process process VB cord-010119-t1x9gknd 2877 35 all all DT cord-010119-t1x9gknd 2877 36 5 5 CD cord-010119-t1x9gknd 2877 37 units unit NNS cord-010119-t1x9gknd 2877 38 . . . cord-010119-t1x9gknd 2878 1 This this DT cord-010119-t1x9gknd 2878 2 was be VBD cord-010119-t1x9gknd 2878 3 performed perform VBN cord-010119-t1x9gknd 2878 4 twice twice RB cord-010119-t1x9gknd 2878 5 for for IN cord-010119-t1x9gknd 2878 6 a a DT cord-010119-t1x9gknd 2878 7 total total NN cord-010119-t1x9gknd 2878 8 of of IN cord-010119-t1x9gknd 2878 9 10 10 CD cord-010119-t1x9gknd 2878 10 Units unit NNS cord-010119-t1x9gknd 2878 11 processed process VBN cord-010119-t1x9gknd 2878 12 in in IN cord-010119-t1x9gknd 2878 13 this this DT cord-010119-t1x9gknd 2878 14 manner manner NN cord-010119-t1x9gknd 2878 15 . . . cord-010119-t1x9gknd 2879 1 Results/ Results/ . cord-010119-t1x9gknd 2880 1 Finding find VBG cord-010119-t1x9gknd 2881 1 : : : cord-010119-t1x9gknd 2881 2 The the DT cord-010119-t1x9gknd 2881 3 volume volume NN cord-010119-t1x9gknd 2881 4 reduction reduction NN cord-010119-t1x9gknd 2881 5 procedure procedure NN cord-010119-t1x9gknd 2881 6 reduced reduce VBD cord-010119-t1x9gknd 2881 7 the the DT cord-010119-t1x9gknd 2881 8 supernatant supernatant JJ cord-010119-t1x9gknd 2881 9 volume volume NN cord-010119-t1x9gknd 2881 10 by by IN cord-010119-t1x9gknd 2881 11 an an DT cord-010119-t1x9gknd 2881 12 average average NN cord-010119-t1x9gknd 2881 13 of of IN cord-010119-t1x9gknd 2881 14 72 72 CD cord-010119-t1x9gknd 2881 15 % % NN cord-010119-t1x9gknd 2881 16 ( ( -LRB- cord-010119-t1x9gknd 2881 17 range range NN cord-010119-t1x9gknd 2881 18 49%-87 49%-87 CD cord-010119-t1x9gknd 2881 19 % % NN cord-010119-t1x9gknd 2881 20 ) ) -RRB- cord-010119-t1x9gknd 2881 21 . . . cord-010119-t1x9gknd 2882 1 In in IN cord-010119-t1x9gknd 2882 2 units unit NNS cord-010119-t1x9gknd 2882 3 between between IN cord-010119-t1x9gknd 2882 4 21 21 CD cord-010119-t1x9gknd 2882 5 and and CC cord-010119-t1x9gknd 2882 6 42 42 CD cord-010119-t1x9gknd 2882 7 days day NNS cord-010119-t1x9gknd 2882 8 ( ( -LRB- cord-010119-t1x9gknd 2882 9 n510 n510 NNP cord-010119-t1x9gknd 2882 10 ) ) -RRB- cord-010119-t1x9gknd 2882 11 , , , cord-010119-t1x9gknd 2882 12 the the DT cord-010119-t1x9gknd 2882 13 estimated estimate VBN cord-010119-t1x9gknd 2882 14 mean mean NN cord-010119-t1x9gknd 2882 15 residual residual JJ cord-010119-t1x9gknd 2882 16 K1 K1 NNP cord-010119-t1x9gknd 2882 17 was be VBD cord-010119-t1x9gknd 2882 18 1.89 1.89 CD cord-010119-t1x9gknd 2882 19 mEq mEq NNS cord-010119-t1x9gknd 2883 1 ( ( -LRB- cord-010119-t1x9gknd 2883 2 Range range NN cord-010119-t1x9gknd 2883 3 0.61 0.61 CD cord-010119-t1x9gknd 2883 4 to to IN cord-010119-t1x9gknd 2883 5 2.21 2.21 CD cord-010119-t1x9gknd 2883 6 ) ) -RRB- cord-010119-t1x9gknd 2883 7 . . . cord-010119-t1x9gknd 2884 1 In in IN cord-010119-t1x9gknd 2884 2 the the DT cord-010119-t1x9gknd 2884 3 two two CD cord-010119-t1x9gknd 2884 4 mock mock JJ cord-010119-t1x9gknd 2884 5 MTP MTP NNP cord-010119-t1x9gknd 2884 6 trials trial NNS cord-010119-t1x9gknd 2884 7 , , , cord-010119-t1x9gknd 2884 8 the the DT cord-010119-t1x9gknd 2884 9 time time NN cord-010119-t1x9gknd 2884 10 to to TO cord-010119-t1x9gknd 2884 11 complete complete VB cord-010119-t1x9gknd 2884 12 the the DT cord-010119-t1x9gknd 2884 13 procedure procedure NN cord-010119-t1x9gknd 2884 14 was be VBD cord-010119-t1x9gknd 2884 15 approximately approximately RB cord-010119-t1x9gknd 2884 16 50 50 CD cord-010119-t1x9gknd 2884 17 minutes minute NNS cord-010119-t1x9gknd 2884 18 and and CC cord-010119-t1x9gknd 2884 19 we -PRON- PRP cord-010119-t1x9gknd 2884 20 estimate estimate VBP cord-010119-t1x9gknd 2884 21 an an DT cord-010119-t1x9gknd 2884 22 additional additional JJ cord-010119-t1x9gknd 2884 23 5 5 CD cord-010119-t1x9gknd 2884 24 - - SYM cord-010119-t1x9gknd 2884 25 10 10 CD cord-010119-t1x9gknd 2884 26 minutes minute NNS cord-010119-t1x9gknd 2884 27 would would MD cord-010119-t1x9gknd 2884 28 be be VB cord-010119-t1x9gknd 2884 29 required require VBN cord-010119-t1x9gknd 2884 30 to to TO cord-010119-t1x9gknd 2884 31 modify modify VB cord-010119-t1x9gknd 2884 32 and and CC cord-010119-t1x9gknd 2884 33 issue issue VB cord-010119-t1x9gknd 2884 34 the the DT cord-010119-t1x9gknd 2884 35 units unit NNS cord-010119-t1x9gknd 2884 36 in in IN cord-010119-t1x9gknd 2884 37 our -PRON- PRP$ cord-010119-t1x9gknd 2884 38 LIS LIS NNP cord-010119-t1x9gknd 2884 39 / / SYM cord-010119-t1x9gknd 2884 40 EMR EMR NNP cord-010119-t1x9gknd 2884 41 . . . cord-010119-t1x9gknd 2885 1 Conclusion conclusion NN cord-010119-t1x9gknd 2885 2 : : : cord-010119-t1x9gknd 2886 1 A a DT cord-010119-t1x9gknd 2886 2 manual manual JJ cord-010119-t1x9gknd 2886 3 volume volume NN cord-010119-t1x9gknd 2886 4 reduction reduction NN cord-010119-t1x9gknd 2886 5 protocol protocol NN cord-010119-t1x9gknd 2886 6 in in IN cord-010119-t1x9gknd 2886 7 red red JJ cord-010119-t1x9gknd 2886 8 cell cell NN cord-010119-t1x9gknd 2886 9 units unit NNS cord-010119-t1x9gknd 2886 10 significantly significantly RB cord-010119-t1x9gknd 2886 11 reduces reduce VBZ cord-010119-t1x9gknd 2886 12 the the DT cord-010119-t1x9gknd 2886 13 amount amount NN cord-010119-t1x9gknd 2886 14 of of IN cord-010119-t1x9gknd 2886 15 potassium potassium NN cord-010119-t1x9gknd 2886 16 administered administer VBN cord-010119-t1x9gknd 2886 17 in in IN cord-010119-t1x9gknd 2886 18 a a DT cord-010119-t1x9gknd 2886 19 unit unit NN cord-010119-t1x9gknd 2886 20 of of IN cord-010119-t1x9gknd 2886 21 red red JJ cord-010119-t1x9gknd 2886 22 cells cell NNS cord-010119-t1x9gknd 2886 23 . . . cord-010119-t1x9gknd 2887 1 This this DT cord-010119-t1x9gknd 2887 2 procedure procedure NN cord-010119-t1x9gknd 2887 3 may may MD cord-010119-t1x9gknd 2887 4 be be VB cord-010119-t1x9gknd 2887 5 useful useful JJ cord-010119-t1x9gknd 2887 6 when when WRB cord-010119-t1x9gknd 2887 7 only only RB cord-010119-t1x9gknd 2887 8 older old JJR cord-010119-t1x9gknd 2887 9 red red JJ cord-010119-t1x9gknd 2887 10 cell cell NN cord-010119-t1x9gknd 2887 11 units unit NNS cord-010119-t1x9gknd 2887 12 are be VBP cord-010119-t1x9gknd 2887 13 available available JJ cord-010119-t1x9gknd 2887 14 for for IN cord-010119-t1x9gknd 2887 15 a a DT cord-010119-t1x9gknd 2887 16 patient patient NN cord-010119-t1x9gknd 2887 17 at at IN cord-010119-t1x9gknd 2887 18 risk risk NN cord-010119-t1x9gknd 2887 19 for for IN cord-010119-t1x9gknd 2887 20 hyperkalemia hyperkalemia NN cord-010119-t1x9gknd 2887 21 . . . cord-010119-t1x9gknd 2888 1 The the DT cord-010119-t1x9gknd 2888 2 procedure procedure NN cord-010119-t1x9gknd 2888 3 can can MD cord-010119-t1x9gknd 2888 4 be be VB cord-010119-t1x9gknd 2888 5 performed perform VBN cord-010119-t1x9gknd 2888 6 in in IN cord-010119-t1x9gknd 2888 7 less less JJR cord-010119-t1x9gknd 2888 8 than than IN cord-010119-t1x9gknd 2888 9 one one CD cord-010119-t1x9gknd 2888 10 hour hour NN cord-010119-t1x9gknd 2888 11 and and CC cord-010119-t1x9gknd 2888 12 may may MD cord-010119-t1x9gknd 2888 13 be be VB cord-010119-t1x9gknd 2888 14 useful useful JJ cord-010119-t1x9gknd 2888 15 under under IN cord-010119-t1x9gknd 2888 16 the the DT cord-010119-t1x9gknd 2888 17 conditions condition NNS cord-010119-t1x9gknd 2888 18 of of IN cord-010119-t1x9gknd 2888 19 massive massive JJ cord-010119-t1x9gknd 2888 20 transfusion transfusion NN cord-010119-t1x9gknd 2888 21 . . . cord-010119-t1x9gknd 2889 1 processing processing NN cord-010119-t1x9gknd 2889 2 , , , cord-010119-t1x9gknd 2889 3 cryopreservation cryopreservation NN cord-010119-t1x9gknd 2889 4 , , , cord-010119-t1x9gknd 2889 5 and and CC cord-010119-t1x9gknd 2889 6 non non JJ cord-010119-t1x9gknd 2889 7 - - JJ cord-010119-t1x9gknd 2889 8 specialized specialized JJ cord-010119-t1x9gknd 2889 9 hospital hospital NN cord-010119-t1x9gknd 2889 10 collection collection NN cord-010119-t1x9gknd 2889 11 . . . cord-010119-t1x9gknd 2890 1 Preliminary preliminary JJ cord-010119-t1x9gknd 2890 2 studies study NNS cord-010119-t1x9gknd 2890 3 of of IN cord-010119-t1x9gknd 2890 4 three three CD cord-010119-t1x9gknd 2890 5 shipping shipping NN cord-010119-t1x9gknd 2890 6 conditions condition NNS cord-010119-t1x9gknd 2890 7 after after IN cord-010119-t1x9gknd 2890 8 collection collection NN cord-010119-t1x9gknd 2890 9 were be VBD cord-010119-t1x9gknd 2890 10 tested test VBN cord-010119-t1x9gknd 2890 11 using use VBG cord-010119-t1x9gknd 2890 12 sterile sterile JJ cord-010119-t1x9gknd 2890 13 containers container NNS cord-010119-t1x9gknd 2890 14 with with IN cord-010119-t1x9gknd 2890 15 sterile sterile JJ cord-010119-t1x9gknd 2890 16 normal normal JJ cord-010119-t1x9gknd 2890 17 saline saline NN cord-010119-t1x9gknd 2890 18 ( ( -LRB- cord-010119-t1x9gknd 2890 19 NS NS NNP cord-010119-t1x9gknd 2890 20 ) ) -RRB- cord-010119-t1x9gknd 2890 21 alone alone RB cord-010119-t1x9gknd 2890 22 , , , cord-010119-t1x9gknd 2890 23 NS NS NNP cord-010119-t1x9gknd 2890 24 plus plus CC cord-010119-t1x9gknd 2890 25 antibiotic antibiotic NN cord-010119-t1x9gknd 2890 26 / / SYM cord-010119-t1x9gknd 2890 27 antimycotic antimycotic JJ cord-010119-t1x9gknd 2890 28 ( ( -LRB- cord-010119-t1x9gknd 2890 29 AB AB NNP cord-010119-t1x9gknd 2890 30 / / SYM cord-010119-t1x9gknd 2890 31 AM AM NNP cord-010119-t1x9gknd 2890 32 ) ) -RRB- cord-010119-t1x9gknd 2890 33 and and CC cord-010119-t1x9gknd 2890 34 a a DT cord-010119-t1x9gknd 2890 35 dry dry JJ cord-010119-t1x9gknd 2890 36 container container NN cord-010119-t1x9gknd 2890 37 . . . cord-010119-t1x9gknd 2891 1 Prolonged prolonged JJ cord-010119-t1x9gknd 2891 2 exposure exposure NN cord-010119-t1x9gknd 2891 3 to to IN cord-010119-t1x9gknd 2891 4 AB AB NNP cord-010119-t1x9gknd 2891 5 / / SYM cord-010119-t1x9gknd 2891 6 AM AM NNP cord-010119-t1x9gknd 2891 7 solution solution NN cord-010119-t1x9gknd 2891 8 retarded retarded JJ cord-010119-t1x9gknd 2891 9 outgrowth outgrowth NN cord-010119-t1x9gknd 2891 10 of of IN cord-010119-t1x9gknd 2891 11 MSCs msc NNS cord-010119-t1x9gknd 2891 12 , , , cord-010119-t1x9gknd 2891 13 but but CC cord-010119-t1x9gknd 2891 14 control control NN cord-010119-t1x9gknd 2891 15 of of IN cord-010119-t1x9gknd 2891 16 microbial microbial JJ cord-010119-t1x9gknd 2891 17 growth growth NN cord-010119-t1x9gknd 2891 18 in in IN cord-010119-t1x9gknd 2891 19 cultured cultured JJ cord-010119-t1x9gknd 2891 20 tissue tissue NN cord-010119-t1x9gknd 2891 21 samples sample NNS cord-010119-t1x9gknd 2891 22 was be VBD cord-010119-t1x9gknd 2891 23 needed need VBN cord-010119-t1x9gknd 2891 24 . . . cord-010119-t1x9gknd 2892 1 These these DT cord-010119-t1x9gknd 2892 2 findings finding NNS cord-010119-t1x9gknd 2892 3 were be VBD cord-010119-t1x9gknd 2892 4 used use VBN cord-010119-t1x9gknd 2892 5 to to TO cord-010119-t1x9gknd 2892 6 construct construct VB cord-010119-t1x9gknd 2892 7 a a DT cord-010119-t1x9gknd 2892 8 validation validation NN cord-010119-t1x9gknd 2892 9 study study NN cord-010119-t1x9gknd 2892 10 . . . cord-010119-t1x9gknd 2893 1 Study Study NNP cord-010119-t1x9gknd 2893 2 Design Design NNP cord-010119-t1x9gknd 2893 3 / / SYM cord-010119-t1x9gknd 2893 4 Methods method NNS cord-010119-t1x9gknd 2893 5 : : : cord-010119-t1x9gknd 2894 1 A a DT cord-010119-t1x9gknd 2894 2 validation validation NN cord-010119-t1x9gknd 2894 3 study study NN cord-010119-t1x9gknd 2894 4 designed design VBN cord-010119-t1x9gknd 2894 5 to to TO cord-010119-t1x9gknd 2894 6 test test VB cord-010119-t1x9gknd 2894 7 procedures procedure NNS cord-010119-t1x9gknd 2894 8 to to TO cord-010119-t1x9gknd 2894 9 collect collect VB cord-010119-t1x9gknd 2894 10 , , , cord-010119-t1x9gknd 2894 11 transport transport NN cord-010119-t1x9gknd 2894 12 , , , cord-010119-t1x9gknd 2894 13 process process NN cord-010119-t1x9gknd 2894 14 , , , cord-010119-t1x9gknd 2894 15 and and CC cord-010119-t1x9gknd 2894 16 store store VB cord-010119-t1x9gknd 2894 17 umbilical umbilical JJ cord-010119-t1x9gknd 2894 18 cord cord NN cord-010119-t1x9gknd 2894 19 tissue tissue NN cord-010119-t1x9gknd 2894 20 was be VBD cord-010119-t1x9gknd 2894 21 measured measure VBN cord-010119-t1x9gknd 2894 22 by by IN cord-010119-t1x9gknd 2894 23 post post JJ cord-010119-t1x9gknd 2894 24 - - JJ cord-010119-t1x9gknd 2894 25 thaw thaw VB cord-010119-t1x9gknd 2894 26 outgrowth outgrowth NN cord-010119-t1x9gknd 2894 27 . . . cord-010119-t1x9gknd 2895 1 Collected collect VBN cord-010119-t1x9gknd 2895 2 UC UC NNP cord-010119-t1x9gknd 2895 3 tissue tissue NN cord-010119-t1x9gknd 2895 4 from from IN cord-010119-t1x9gknd 2895 5 consenting consent VBG cord-010119-t1x9gknd 2895 6 mothers mother NNS cord-010119-t1x9gknd 2895 7 was be VBD cord-010119-t1x9gknd 2895 8 transported transport VBN cord-010119-t1x9gknd 2895 9 to to IN cord-010119-t1x9gknd 2895 10 the the DT cord-010119-t1x9gknd 2895 11 distant distant JJ cord-010119-t1x9gknd 2895 12 lab lab NN cord-010119-t1x9gknd 2895 13 in in IN cord-010119-t1x9gknd 2895 14 validated validate VBN cord-010119-t1x9gknd 2895 15 shipping shipping NN cord-010119-t1x9gknd 2895 16 containers container NNS cord-010119-t1x9gknd 2895 17 in in IN cord-010119-t1x9gknd 2895 18 a a DT cord-010119-t1x9gknd 2895 19 dry dry JJ cord-010119-t1x9gknd 2895 20 , , , cord-010119-t1x9gknd 2895 21 sterile sterile JJ cord-010119-t1x9gknd 2895 22 cup cup NN cord-010119-t1x9gknd 2895 23 from from IN cord-010119-t1x9gknd 2895 24 vaginal vaginal JJ cord-010119-t1x9gknd 2895 25 ( ( -LRB- cord-010119-t1x9gknd 2895 26 3 3 CD cord-010119-t1x9gknd 2895 27 ) ) -RRB- cord-010119-t1x9gknd 2895 28 and and CC cord-010119-t1x9gknd 2895 29 caesarian caesarian NN cord-010119-t1x9gknd 2895 30 ( ( -LRB- cord-010119-t1x9gknd 2895 31 2 2 CD cord-010119-t1x9gknd 2895 32 ) ) -RRB- cord-010119-t1x9gknd 2895 33 births birth NNS cord-010119-t1x9gknd 2895 34 . . . cord-010119-t1x9gknd 2896 1 UC UC NNP cord-010119-t1x9gknd 2896 2 collections collection NNS cord-010119-t1x9gknd 2896 3 were be VBD cord-010119-t1x9gknd 2896 4 divided divide VBN cord-010119-t1x9gknd 2896 5 into into IN cord-010119-t1x9gknd 2896 6 3 3 CD cord-010119-t1x9gknd 2896 7 segments segment NNS cord-010119-t1x9gknd 2896 8 to to TO cord-010119-t1x9gknd 2896 9 test test VB cord-010119-t1x9gknd 2896 10 3 3 CD cord-010119-t1x9gknd 2896 11 conditions condition NNS cord-010119-t1x9gknd 2896 12 . . . cord-010119-t1x9gknd 2897 1 Segment segment NN cord-010119-t1x9gknd 2897 2 explants explant NNS cord-010119-t1x9gknd 2897 3 were be VBD cord-010119-t1x9gknd 2897 4 placed place VBN cord-010119-t1x9gknd 2897 5 on on IN cord-010119-t1x9gknd 2897 6 0.1 0.1 CD cord-010119-t1x9gknd 2897 7 % % NN cord-010119-t1x9gknd 2897 8 gelatin gelatin NN cord-010119-t1x9gknd 2897 9 - - HYPH cord-010119-t1x9gknd 2897 10 coated coat VBN cord-010119-t1x9gknd 2897 11 gridded gridded JJ cord-010119-t1x9gknd 2897 12 tissue tissue NN cord-010119-t1x9gknd 2897 13 culture culture NN cord-010119-t1x9gknd 2897 14 plates plate NNS cord-010119-t1x9gknd 2897 15 ( ( -LRB- cord-010119-t1x9gknd 2897 16 32 32 CD cord-010119-t1x9gknd 2897 17 explants explant NNS cord-010119-t1x9gknd 2897 18 per per IN cord-010119-t1x9gknd 2897 19 plate plate NN cord-010119-t1x9gknd 2897 20 ) ) -RRB- cord-010119-t1x9gknd 2897 21 in in IN cord-010119-t1x9gknd 2897 22 enriched enrich VBN cord-010119-t1x9gknd 2897 23 medium medium NN cord-010119-t1x9gknd 2897 24 specified specify VBN cord-010119-t1x9gknd 2897 25 for for IN cord-010119-t1x9gknd 2897 26 MSC MSC NNP cord-010119-t1x9gknd 2897 27 outgrowth outgrowth NN cord-010119-t1x9gknd 2897 28 containing contain VBG cord-010119-t1x9gknd 2897 29 antibiotic antibiotic JJ cord-010119-t1x9gknd 2897 30 only only RB cord-010119-t1x9gknd 2897 31 with with IN cord-010119-t1x9gknd 2897 32 an an DT cord-010119-t1x9gknd 2897 33 endpoint endpoint NN cord-010119-t1x9gknd 2897 34 of of IN cord-010119-t1x9gknd 2897 35 21 21 CD cord-010119-t1x9gknd 2897 36 days day NNS cord-010119-t1x9gknd 2897 37 . . . cord-010119-t1x9gknd 2898 1 Growth growth NN cord-010119-t1x9gknd 2898 2 was be VBD cord-010119-t1x9gknd 2898 3 scored score VBN cord-010119-t1x9gknd 2898 4 as as IN cord-010119-t1x9gknd 2898 5 the the DT cord-010119-t1x9gknd 2898 6 number number NN cord-010119-t1x9gknd 2898 7 of of IN cord-010119-t1x9gknd 2898 8 squares square NNS cord-010119-t1x9gknd 2898 9 with with IN cord-010119-t1x9gknd 2898 10 explants explant NNS cord-010119-t1x9gknd 2898 11 exhibiting exhibit VBG cord-010119-t1x9gknd 2898 12 outgrowth outgrowth NN cord-010119-t1x9gknd 2898 13 compared compare VBN cord-010119-t1x9gknd 2898 14 to to IN cord-010119-t1x9gknd 2898 15 the the DT cord-010119-t1x9gknd 2898 16 total total JJ cord-010119-t1x9gknd 2898 17 planted plant VBN cord-010119-t1x9gknd 2898 18 explants explant NNS cord-010119-t1x9gknd 2898 19 . . . cord-010119-t1x9gknd 2899 1 One one CD cord-010119-t1x9gknd 2899 2 segment segment NN cord-010119-t1x9gknd 2899 3 ( ( -LRB- cord-010119-t1x9gknd 2899 4 fresh fresh JJ cord-010119-t1x9gknd 2899 5 control control NN cord-010119-t1x9gknd 2899 6 ) ) -RRB- cord-010119-t1x9gknd 2899 7 was be VBD cord-010119-t1x9gknd 2899 8 dissected dissect VBN cord-010119-t1x9gknd 2899 9 and and CC cord-010119-t1x9gknd 2899 10 planted plant VBN cord-010119-t1x9gknd 2899 11 without without IN cord-010119-t1x9gknd 2899 12 further further JJ cord-010119-t1x9gknd 2899 13 processing processing NN cord-010119-t1x9gknd 2899 14 . . . cord-010119-t1x9gknd 2900 1 The the DT cord-010119-t1x9gknd 2900 2 2 2 CD cord-010119-t1x9gknd 2900 3 remaining remain VBG cord-010119-t1x9gknd 2900 4 tissue tissue NN cord-010119-t1x9gknd 2900 5 segments segment NNS cord-010119-t1x9gknd 2900 6 were be VBD cord-010119-t1x9gknd 2900 7 soaked soak VBN cord-010119-t1x9gknd 2900 8 in in IN cord-010119-t1x9gknd 2900 9 ( ( -LRB- cord-010119-t1x9gknd 2900 10 AB AB NNP cord-010119-t1x9gknd 2900 11 / / SYM cord-010119-t1x9gknd 2900 12 AM am NN cord-010119-t1x9gknd 2900 13 ) ) -RRB- cord-010119-t1x9gknd 2900 14 saline saline NN cord-010119-t1x9gknd 2900 15 solution solution NN cord-010119-t1x9gknd 2900 16 for for IN cord-010119-t1x9gknd 2900 17 1 1 CD cord-010119-t1x9gknd 2900 18 hr hr NN cord-010119-t1x9gknd 2900 19 and and CC cord-010119-t1x9gknd 2900 20 24 24 CD cord-010119-t1x9gknd 2900 21 hrs hrs NN cord-010119-t1x9gknd 2900 22 at at IN cord-010119-t1x9gknd 2900 23 48C 48c CD cord-010119-t1x9gknd 2900 24 , , , cord-010119-t1x9gknd 2900 25 respectively respectively RB cord-010119-t1x9gknd 2900 26 . . . cord-010119-t1x9gknd 2901 1 Tissue tissue NN cord-010119-t1x9gknd 2901 2 segments segment NNS cord-010119-t1x9gknd 2901 3 were be VBD cord-010119-t1x9gknd 2901 4 frozen freeze VBN cord-010119-t1x9gknd 2901 5 in in IN cord-010119-t1x9gknd 2901 6 cryo cryo NN cord-010119-t1x9gknd 2901 7 bags bag NNS cord-010119-t1x9gknd 2901 8 with with IN cord-010119-t1x9gknd 2901 9 a a DT cord-010119-t1x9gknd 2901 10 proprietary proprietary JJ cord-010119-t1x9gknd 2901 11 10 10 CD cord-010119-t1x9gknd 2901 12 % % NN cord-010119-t1x9gknd 2901 13 DMSO DMSO NNP cord-010119-t1x9gknd 2901 14 / / SYM cord-010119-t1x9gknd 2901 15 large large JJ cord-010119-t1x9gknd 2901 16 molecular molecular JJ cord-010119-t1x9gknd 2901 17 weight weight NN cord-010119-t1x9gknd 2901 18 sugar sugar NN cord-010119-t1x9gknd 2901 19 solution solution NN cord-010119-t1x9gknd 2901 20 . . . cord-010119-t1x9gknd 2902 1 Background Background NNP cord-010119-t1x9gknd 2902 2 / / SYM cord-010119-t1x9gknd 2902 3 Case Case NNP cord-010119-t1x9gknd 2902 4 Studies Studies NNPS cord-010119-t1x9gknd 2903 1 : : : cord-010119-t1x9gknd 2903 2 It -PRON- PRP cord-010119-t1x9gknd 2903 3 has have VBZ cord-010119-t1x9gknd 2903 4 been be VBN cord-010119-t1x9gknd 2903 5 the the DT cord-010119-t1x9gknd 2903 6 practice practice NN cord-010119-t1x9gknd 2903 7 in in IN cord-010119-t1x9gknd 2903 8 our -PRON- PRP$ cord-010119-t1x9gknd 2903 9 institution institution NN cord-010119-t1x9gknd 2903 10 to to TO cord-010119-t1x9gknd 2903 11 process process VB cord-010119-t1x9gknd 2903 12 3 3 CD cord-010119-t1x9gknd 2903 13 or or CC cord-010119-t1x9gknd 2903 14 4 4 CD cord-010119-t1x9gknd 2903 15 times time NNS cord-010119-t1x9gknd 2903 16 the the DT cord-010119-t1x9gknd 2903 17 total total JJ cord-010119-t1x9gknd 2903 18 blood blood NN cord-010119-t1x9gknd 2903 19 volume volume NN cord-010119-t1x9gknd 2903 20 ( ( -LRB- cord-010119-t1x9gknd 2903 21 BV BV NNP cord-010119-t1x9gknd 2903 22 ) ) -RRB- cord-010119-t1x9gknd 2903 23 of of IN cord-010119-t1x9gknd 2903 24 the the DT cord-010119-t1x9gknd 2903 25 patient patient NN cord-010119-t1x9gknd 2903 26 , , , cord-010119-t1x9gknd 2903 27 up up IN cord-010119-t1x9gknd 2903 28 to to IN cord-010119-t1x9gknd 2903 29 a a DT cord-010119-t1x9gknd 2903 30 maximum maximum NN cord-010119-t1x9gknd 2903 31 of of IN cord-010119-t1x9gknd 2903 32 25 25 CD cord-010119-t1x9gknd 2903 33 liters liter NNS cord-010119-t1x9gknd 2903 34 ( ( -LRB- cord-010119-t1x9gknd 2903 35 L l NN cord-010119-t1x9gknd 2903 36 ) ) -RRB- cord-010119-t1x9gknd 2903 37 per per IN cord-010119-t1x9gknd 2903 38 procedure procedure NN cord-010119-t1x9gknd 2903 39 , , , cord-010119-t1x9gknd 2903 40 to to TO cord-010119-t1x9gknd 2903 41 obtain obtain VB cord-010119-t1x9gknd 2903 42 peripheral peripheral JJ cord-010119-t1x9gknd 2903 43 blood blood NN cord-010119-t1x9gknd 2903 44 CD341 cd341 NN cord-010119-t1x9gknd 2903 45 stem stem NN cord-010119-t1x9gknd 2903 46 cells cell NNS cord-010119-t1x9gknd 2903 47 . . . cord-010119-t1x9gknd 2904 1 As as IN cord-010119-t1x9gknd 2904 2 a a DT cord-010119-t1x9gknd 2904 3 consequence consequence NN cord-010119-t1x9gknd 2904 4 , , , cord-010119-t1x9gknd 2904 5 a a DT cord-010119-t1x9gknd 2904 6 patient patient NN cord-010119-t1x9gknd 2904 7 often often RB cord-010119-t1x9gknd 2904 8 would would MD cord-010119-t1x9gknd 2904 9 need need VB cord-010119-t1x9gknd 2904 10 to to TO cord-010119-t1x9gknd 2904 11 spend spend VB cord-010119-t1x9gknd 2904 12 6 6 CD cord-010119-t1x9gknd 2904 13 hours hour NNS cord-010119-t1x9gknd 2904 14 or or CC cord-010119-t1x9gknd 2904 15 more more JJR cord-010119-t1x9gknd 2904 16 on on IN cord-010119-t1x9gknd 2904 17 the the DT cord-010119-t1x9gknd 2904 18 machine machine NN cord-010119-t1x9gknd 2904 19 . . . cord-010119-t1x9gknd 2905 1 It -PRON- PRP cord-010119-t1x9gknd 2905 2 would would MD cord-010119-t1x9gknd 2905 3 be be VB cord-010119-t1x9gknd 2905 4 desirable desirable JJ cord-010119-t1x9gknd 2905 5 to to TO cord-010119-t1x9gknd 2905 6 be be VB cord-010119-t1x9gknd 2905 7 able able JJ cord-010119-t1x9gknd 2905 8 to to TO cord-010119-t1x9gknd 2905 9 specify specify VB cord-010119-t1x9gknd 2905 10 the the DT cord-010119-t1x9gknd 2905 11 exact exact JJ cord-010119-t1x9gknd 2905 12 volume volume NN cord-010119-t1x9gknd 2905 13 of of IN cord-010119-t1x9gknd 2905 14 blood blood NN cord-010119-t1x9gknd 2905 15 to to TO cord-010119-t1x9gknd 2905 16 process process VB cord-010119-t1x9gknd 2905 17 to to TO cord-010119-t1x9gknd 2905 18 achieve achieve VB cord-010119-t1x9gknd 2905 19 the the DT cord-010119-t1x9gknd 2905 20 desired desire VBN cord-010119-t1x9gknd 2905 21 CD341 cd341 NN cord-010119-t1x9gknd 2905 22 cell cell NN cord-010119-t1x9gknd 2905 23 yield yield NN cord-010119-t1x9gknd 2905 24 , , , cord-010119-t1x9gknd 2905 25 thus thus RB cord-010119-t1x9gknd 2905 26 minimizing minimize VBG cord-010119-t1x9gknd 2905 27 the the DT cord-010119-t1x9gknd 2905 28 patient patient NN cord-010119-t1x9gknd 2905 29 's 's POS cord-010119-t1x9gknd 2905 30 time time NN cord-010119-t1x9gknd 2905 31 on on IN cord-010119-t1x9gknd 2905 32 the the DT cord-010119-t1x9gknd 2905 33 machine machine NN cord-010119-t1x9gknd 2905 34 , , , cord-010119-t1x9gknd 2905 35 the the DT cord-010119-t1x9gknd 2905 36 nurse nurse NN cord-010119-t1x9gknd 2905 37 's 's POS cord-010119-t1x9gknd 2905 38 time time NN cord-010119-t1x9gknd 2905 39 performing perform VBG cord-010119-t1x9gknd 2905 40 the the DT cord-010119-t1x9gknd 2905 41 procedure procedure NN cord-010119-t1x9gknd 2905 42 , , , cord-010119-t1x9gknd 2905 43 and and CC cord-010119-t1x9gknd 2905 44 the the DT cord-010119-t1x9gknd 2905 45 number number NN cord-010119-t1x9gknd 2905 46 of of IN cord-010119-t1x9gknd 2905 47 bags bag NNS cord-010119-t1x9gknd 2905 48 that that WDT cord-010119-t1x9gknd 2905 49 have have VBP cord-010119-t1x9gknd 2905 50 to to TO cord-010119-t1x9gknd 2905 51 be be VB cord-010119-t1x9gknd 2905 52 submitted submit VBN cord-010119-t1x9gknd 2905 53 for for IN cord-010119-t1x9gknd 2905 54 cryopreservation cryopreservation NN cord-010119-t1x9gknd 2905 55 and and CC cord-010119-t1x9gknd 2905 56 storage storage NN cord-010119-t1x9gknd 2905 57 . . . cord-010119-t1x9gknd 2906 1 Study Study NNP cord-010119-t1x9gknd 2906 2 Design Design NNP cord-010119-t1x9gknd 2906 3 / / SYM cord-010119-t1x9gknd 2906 4 Methods method NNS cord-010119-t1x9gknd 2906 5 : : : cord-010119-t1x9gknd 2906 6 Our -PRON- PRP$ cord-010119-t1x9gknd 2906 7 institution institution NN cord-010119-t1x9gknd 2906 8 recently recently RB cord-010119-t1x9gknd 2906 9 implemented implement VBD cord-010119-t1x9gknd 2906 10 the the DT cord-010119-t1x9gknd 2906 11 new new JJ cord-010119-t1x9gknd 2906 12 Spectra Spectra NNP cord-010119-t1x9gknd 2906 13 Optia Optia NNP cord-010119-t1x9gknd 2906 14 CMNC CMNC NNP cord-010119-t1x9gknd 2906 15 collection collection NN cord-010119-t1x9gknd 2906 16 protocol protocol NN cord-010119-t1x9gknd 2906 17 , , , cord-010119-t1x9gknd 2906 18 a a DT cord-010119-t1x9gknd 2906 19 continuous continuous JJ cord-010119-t1x9gknd 2906 20 flow flow NN cord-010119-t1x9gknd 2906 21 and and CC cord-010119-t1x9gknd 2906 22 continuous continuous JJ cord-010119-t1x9gknd 2906 23 collection collection NN cord-010119-t1x9gknd 2906 24 procedure procedure NN cord-010119-t1x9gknd 2906 25 that that WDT cord-010119-t1x9gknd 2906 26 uses use VBZ cord-010119-t1x9gknd 2906 27 the the DT cord-010119-t1x9gknd 2906 28 Automated Automated NNP cord-010119-t1x9gknd 2906 29 Interface Interface NNP cord-010119-t1x9gknd 2906 30 Management Management NNP cord-010119-t1x9gknd 2906 31 ( ( -LRB- cord-010119-t1x9gknd 2906 32 AIM aim NN cord-010119-t1x9gknd 2906 33 ) ) -RRB- cord-010119-t1x9gknd 2906 34 system system NN cord-010119-t1x9gknd 2906 35 to to TO cord-010119-t1x9gknd 2906 36 precisely precisely RB cord-010119-t1x9gknd 2906 37 manage manage VB cord-010119-t1x9gknd 2906 38 the the DT cord-010119-t1x9gknd 2906 39 separation separation NN cord-010119-t1x9gknd 2906 40 interface interface NN cord-010119-t1x9gknd 2906 41 . . . cord-010119-t1x9gknd 2907 1 An an DT cord-010119-t1x9gknd 2907 2 analysis analysis NN cord-010119-t1x9gknd 2907 3 of of IN cord-010119-t1x9gknd 2907 4 our -PRON- PRP$ cord-010119-t1x9gknd 2907 5 2016 2016 CD cord-010119-t1x9gknd 2907 6 collection collection NN cord-010119-t1x9gknd 2907 7 data datum NNS cord-010119-t1x9gknd 2907 8 suggested suggest VBD cord-010119-t1x9gknd 2907 9 a a DT cord-010119-t1x9gknd 2907 10 highly highly RB cord-010119-t1x9gknd 2907 11 reliable reliable JJ cord-010119-t1x9gknd 2907 12 collection collection NN cord-010119-t1x9gknd 2907 13 process process NN cord-010119-t1x9gknd 2907 14 , , , cord-010119-t1x9gknd 2907 15 so so IN cord-010119-t1x9gknd 2907 16 a a DT cord-010119-t1x9gknd 2907 17 prediction prediction NN cord-010119-t1x9gknd 2907 18 algorithm algorithm NN cord-010119-t1x9gknd 2907 19 ( ( -LRB- cord-010119-t1x9gknd 2907 20 PA PA NNP cord-010119-t1x9gknd 2907 21 ) ) -RRB- cord-010119-t1x9gknd 2907 22 based base VBN cord-010119-t1x9gknd 2907 23 on on IN cord-010119-t1x9gknd 2907 24 the the DT cord-010119-t1x9gknd 2907 25 linear linear JJ cord-010119-t1x9gknd 2907 26 regression regression NN cord-010119-t1x9gknd 2907 27 between between IN cord-010119-t1x9gknd 2907 28 the the DT cord-010119-t1x9gknd 2907 29 patient patient NN cord-010119-t1x9gknd 2907 30 's 's POS cord-010119-t1x9gknd 2907 31 CD341 cd341 NN cord-010119-t1x9gknd 2907 32 pre pre JJ cord-010119-t1x9gknd 2907 33 - - NN cord-010119-t1x9gknd 2907 34 count count NN cord-010119-t1x9gknd 2907 35 and and CC cord-010119-t1x9gknd 2907 36 CD341 cd341 NN cord-010119-t1x9gknd 2907 37 yield yield NN cord-010119-t1x9gknd 2907 38 , , , cord-010119-t1x9gknd 2907 39 normalized normalize VBN cord-010119-t1x9gknd 2907 40 per per IN cord-010119-t1x9gknd 2907 41 liter liter NN cord-010119-t1x9gknd 2907 42 of of IN cord-010119-t1x9gknd 2907 43 blood blood NN cord-010119-t1x9gknd 2907 44 processed process VBN cord-010119-t1x9gknd 2907 45 , , , cord-010119-t1x9gknd 2907 46 was be VBD cord-010119-t1x9gknd 2907 47 derived derive VBN cord-010119-t1x9gknd 2907 48 utilizing utilize VBG cord-010119-t1x9gknd 2907 49 the the DT cord-010119-t1x9gknd 2907 50 patient patient NN cord-010119-t1x9gknd 2907 51 's 's POS cord-010119-t1x9gknd 2907 52 CD341 cd341 NN cord-010119-t1x9gknd 2907 53 pre pre JJ cord-010119-t1x9gknd 2907 54 - - NN cord-010119-t1x9gknd 2907 55 count count VB cord-010119-t1x9gknd 2907 56 , , , cord-010119-t1x9gknd 2907 57 the the DT cord-010119-t1x9gknd 2907 58 patient patient NN cord-010119-t1x9gknd 2907 59 's 's POS cord-010119-t1x9gknd 2907 60 weight weight NN cord-010119-t1x9gknd 2907 61 in in IN cord-010119-t1x9gknd 2907 62 kilograms kilogram NNS cord-010119-t1x9gknd 2907 63 ( ( -LRB- cord-010119-t1x9gknd 2907 64 Kg Kg NNP cord-010119-t1x9gknd 2907 65 ) ) -RRB- cord-010119-t1x9gknd 2907 66 , , , cord-010119-t1x9gknd 2907 67 and and CC cord-010119-t1x9gknd 2907 68 the the DT cord-010119-t1x9gknd 2907 69 target target NN cord-010119-t1x9gknd 2907 70 CD341 cd341 NN cord-010119-t1x9gknd 2907 71 dose dose NN cord-010119-t1x9gknd 2907 72 / / SYM cord-010119-t1x9gknd 2907 73 Kg Kg NNP cord-010119-t1x9gknd 2907 74 . . . cord-010119-t1x9gknd 2908 1 This this DT cord-010119-t1x9gknd 2908 2 PA PA NNP cord-010119-t1x9gknd 2908 3 calculated calculate VBD cord-010119-t1x9gknd 2908 4 the the DT cord-010119-t1x9gknd 2908 5 exact exact JJ cord-010119-t1x9gknd 2908 6 volume volume NN cord-010119-t1x9gknd 2908 7 of of IN cord-010119-t1x9gknd 2908 8 whole whole JJ cord-010119-t1x9gknd 2908 9 blood blood NN cord-010119-t1x9gknd 2908 10 to to TO cord-010119-t1x9gknd 2908 11 be be VB cord-010119-t1x9gknd 2908 12 processed process VBN cord-010119-t1x9gknd 2908 13 to to TO cord-010119-t1x9gknd 2908 14 achieve achieve VB cord-010119-t1x9gknd 2908 15 the the DT cord-010119-t1x9gknd 2908 16 requested request VBN cord-010119-t1x9gknd 2908 17 dose dose NN cord-010119-t1x9gknd 2908 18 of of IN cord-010119-t1x9gknd 2908 19 peripheral peripheral JJ cord-010119-t1x9gknd 2908 20 CD341 cd341 NN cord-010119-t1x9gknd 2908 21 stem stem NN cord-010119-t1x9gknd 2908 22 cells cell NNS cord-010119-t1x9gknd 2908 23 . . . cord-010119-t1x9gknd 2909 1 The the DT cord-010119-t1x9gknd 2909 2 initial initial JJ cord-010119-t1x9gknd 2909 3 equation equation NN cord-010119-t1x9gknd 2909 4 was be VBD cord-010119-t1x9gknd 2909 5 modified modify VBN cord-010119-t1x9gknd 2909 6 to to TO cord-010119-t1x9gknd 2909 7 add add VB cord-010119-t1x9gknd 2909 8 an an DT cord-010119-t1x9gknd 2909 9 additional additional JJ cord-010119-t1x9gknd 2909 10 15 15 CD cord-010119-t1x9gknd 2909 11 % % NN cord-010119-t1x9gknd 2909 12 to to IN cord-010119-t1x9gknd 2909 13 the the DT cord-010119-t1x9gknd 2909 14 predicted predict VBN cord-010119-t1x9gknd 2909 15 volume volume NN cord-010119-t1x9gknd 2909 16 , , , cord-010119-t1x9gknd 2909 17 to to TO cord-010119-t1x9gknd 2909 18 account account VB cord-010119-t1x9gknd 2909 19 for for IN cord-010119-t1x9gknd 2909 20 the the DT cord-010119-t1x9gknd 2909 21 natural natural JJ cord-010119-t1x9gknd 2909 22 variability variability NN cord-010119-t1x9gknd 2909 23 of of IN cord-010119-t1x9gknd 2909 24 the the DT cord-010119-t1x9gknd 2909 25 process process NN cord-010119-t1x9gknd 2909 26 . . . cord-010119-t1x9gknd 2910 1 This this DT cord-010119-t1x9gknd 2910 2 PA PA NNP cord-010119-t1x9gknd 2910 3 was be VBD cord-010119-t1x9gknd 2910 4 then then RB cord-010119-t1x9gknd 2910 5 tested test VBN cord-010119-t1x9gknd 2910 6 prospectively prospectively RB cord-010119-t1x9gknd 2910 7 in in IN cord-010119-t1x9gknd 2910 8 the the DT cord-010119-t1x9gknd 2910 9 clinical clinical JJ cord-010119-t1x9gknd 2910 10 setting setting NN cord-010119-t1x9gknd 2910 11 . . . cord-010119-t1x9gknd 2911 1 Results result NNS cord-010119-t1x9gknd 2911 2 / / SYM cord-010119-t1x9gknd 2911 3 Findings finding NNS cord-010119-t1x9gknd 2911 4 : : : cord-010119-t1x9gknd 2912 1 In in IN cord-010119-t1x9gknd 2912 2 8 8 CD cord-010119-t1x9gknd 2912 3 patients patient NNS cord-010119-t1x9gknd 2912 4 , , , cord-010119-t1x9gknd 2912 5 representing represent VBG cord-010119-t1x9gknd 2912 6 both both CC cord-010119-t1x9gknd 2912 7 allogeneic allogeneic NN cord-010119-t1x9gknd 2912 8 and and CC cord-010119-t1x9gknd 2912 9 autologous autologous JJ cord-010119-t1x9gknd 2912 10 donors donor NNS cord-010119-t1x9gknd 2912 11 , , , cord-010119-t1x9gknd 2912 12 the the DT cord-010119-t1x9gknd 2912 13 average average JJ cord-010119-t1x9gknd 2912 14 blood blood NN cord-010119-t1x9gknd 2912 15 volume volume NN cord-010119-t1x9gknd 2912 16 processed process VBN cord-010119-t1x9gknd 2912 17 was be VBD cord-010119-t1x9gknd 2912 18 14.8 14.8 CD cord-010119-t1x9gknd 2912 19 L. L. NNP cord-010119-t1x9gknd 2913 1 The the DT cord-010119-t1x9gknd 2913 2 range range NN cord-010119-t1x9gknd 2913 3 was be VBD cord-010119-t1x9gknd 2913 4 4.9 4.9 CD cord-010119-t1x9gknd 2913 5 L L NNP cord-010119-t1x9gknd 2913 6 -21.6 -21.6 NNP cord-010119-t1x9gknd 2913 7 L. L. NNP cord-010119-t1x9gknd 2914 1 The the DT cord-010119-t1x9gknd 2914 2 target target NN cord-010119-t1x9gknd 2914 3 dose dose NN cord-010119-t1x9gknd 2914 4 was be VBD cord-010119-t1x9gknd 2914 5 achieved achieve VBN cord-010119-t1x9gknd 2914 6 in in IN cord-010119-t1x9gknd 2914 7 all all DT cord-010119-t1x9gknd 2914 8 patients patient NNS cord-010119-t1x9gknd 2914 9 . . . cord-010119-t1x9gknd 2915 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2915 2 previous previous JJ cord-010119-t1x9gknd 2915 3 practice practice NN cord-010119-t1x9gknd 2915 4 for for IN cord-010119-t1x9gknd 2915 5 these these DT cord-010119-t1x9gknd 2915 6 8 8 CD cord-010119-t1x9gknd 2915 7 patients patient NNS cord-010119-t1x9gknd 2915 8 would would MD cord-010119-t1x9gknd 2915 9 have have VB cord-010119-t1x9gknd 2915 10 required require VBN cord-010119-t1x9gknd 2915 11 , , , cord-010119-t1x9gknd 2915 12 assuming assume VBG cord-010119-t1x9gknd 2915 13 a a DT cord-010119-t1x9gknd 2915 14 standard standard JJ cord-010119-t1x9gknd 2915 15 4 4 CD cord-010119-t1x9gknd 2915 16 BV BV NNP cord-010119-t1x9gknd 2915 17 procedure procedure NN cord-010119-t1x9gknd 2915 18 , , , cord-010119-t1x9gknd 2915 19 processing process VBG cord-010119-t1x9gknd 2915 20 an an DT cord-010119-t1x9gknd 2915 21 average average NN cord-010119-t1x9gknd 2915 22 of of IN cord-010119-t1x9gknd 2915 23 up up IN cord-010119-t1x9gknd 2915 24 to to TO cord-010119-t1x9gknd 2915 25 28 28 CD cord-010119-t1x9gknd 2915 26 L l NN cord-010119-t1x9gknd 2915 27 per per IN cord-010119-t1x9gknd 2915 28 patient patient NN cord-010119-t1x9gknd 2915 29 , , , cord-010119-t1x9gknd 2915 30 with with IN cord-010119-t1x9gknd 2915 31 a a DT cord-010119-t1x9gknd 2915 32 range range NN cord-010119-t1x9gknd 2915 33 of of IN cord-010119-t1x9gknd 2915 34 20 20 CD cord-010119-t1x9gknd 2915 35 - - SYM cord-010119-t1x9gknd 2915 36 62 62 CD cord-010119-t1x9gknd 2915 37 L. L. NNP cord-010119-t1x9gknd 2916 1 To to TO cord-010119-t1x9gknd 2916 2 quantify quantify VB cord-010119-t1x9gknd 2916 3 how how WRB cord-010119-t1x9gknd 2916 4 well well RB cord-010119-t1x9gknd 2916 5 the the DT cord-010119-t1x9gknd 2916 6 new new JJ cord-010119-t1x9gknd 2916 7 PA PA NNP cord-010119-t1x9gknd 2916 8 works work VBZ cord-010119-t1x9gknd 2916 9 , , , cord-010119-t1x9gknd 2916 10 it -PRON- PRP cord-010119-t1x9gknd 2916 11 was be VBD cord-010119-t1x9gknd 2916 12 decided decide VBN cord-010119-t1x9gknd 2916 13 to to TO cord-010119-t1x9gknd 2916 14 evaluate evaluate VB cord-010119-t1x9gknd 2916 15 the the DT cord-010119-t1x9gknd 2916 16 ratio ratio NN cord-010119-t1x9gknd 2916 17 between between IN cord-010119-t1x9gknd 2916 18 actual actual JJ cord-010119-t1x9gknd 2916 19 and and CC cord-010119-t1x9gknd 2916 20 predicted predict VBN cord-010119-t1x9gknd 2916 21 volume volume NN cord-010119-t1x9gknd 2916 22 vs. vs. IN cord-010119-t1x9gknd 2916 23 the the DT cord-010119-t1x9gknd 2916 24 ratio ratio NN cord-010119-t1x9gknd 2916 25 between between IN cord-010119-t1x9gknd 2916 26 the the DT cord-010119-t1x9gknd 2916 27 actual actual JJ cord-010119-t1x9gknd 2916 28 and and CC cord-010119-t1x9gknd 2916 29 expected expected JJ cord-010119-t1x9gknd 2916 30 CD341 cd341 NN cord-010119-t1x9gknd 2916 31 yield yield NN cord-010119-t1x9gknd 2916 32 . . . cord-010119-t1x9gknd 2917 1 The the DT cord-010119-t1x9gknd 2917 2 result result NN cord-010119-t1x9gknd 2917 3 was be VBD cord-010119-t1x9gknd 2917 4 a a DT cord-010119-t1x9gknd 2917 5 high high JJ cord-010119-t1x9gknd 2917 6 correlation correlation NN cord-010119-t1x9gknd 2917 7 between between IN cord-010119-t1x9gknd 2917 8 these these DT cord-010119-t1x9gknd 2917 9 two two CD cord-010119-t1x9gknd 2917 10 ratios ratio NNS cord-010119-t1x9gknd 2917 11 ( ( -LRB- cord-010119-t1x9gknd 2917 12 R r NN cord-010119-t1x9gknd 2917 13 2 2 CD cord-010119-t1x9gknd 2917 14 5 5 CD cord-010119-t1x9gknd 2917 15 0.92 0.92 CD cord-010119-t1x9gknd 2917 16 ) ) -RRB- cord-010119-t1x9gknd 2917 17 , , , cord-010119-t1x9gknd 2917 18 indicating indicate VBG cord-010119-t1x9gknd 2917 19 that that IN cord-010119-t1x9gknd 2917 20 the the DT cord-010119-t1x9gknd 2917 21 algorithm algorithm NN cord-010119-t1x9gknd 2917 22 produces produce VBZ cord-010119-t1x9gknd 2917 23 very very RB cord-010119-t1x9gknd 2917 24 consistent consistent JJ cord-010119-t1x9gknd 2917 25 results result NNS cord-010119-t1x9gknd 2917 26 . . . cord-010119-t1x9gknd 2918 1 Conclusion conclusion NN cord-010119-t1x9gknd 2918 2 : : : cord-010119-t1x9gknd 2919 1 The the DT cord-010119-t1x9gknd 2919 2 predictability predictability NN cord-010119-t1x9gknd 2919 3 of of IN cord-010119-t1x9gknd 2919 4 our -PRON- PRP$ cord-010119-t1x9gknd 2919 5 collection collection NN cord-010119-t1x9gknd 2919 6 process process NN cord-010119-t1x9gknd 2919 7 during during IN cord-010119-t1x9gknd 2919 8 the the DT cord-010119-t1x9gknd 2919 9 time time NN cord-010119-t1x9gknd 2919 10 period period NN cord-010119-t1x9gknd 2919 11 analyzed analyze VBD cord-010119-t1x9gknd 2919 12 was be VBD cord-010119-t1x9gknd 2919 13 a a DT cord-010119-t1x9gknd 2919 14 robust robust JJ cord-010119-t1x9gknd 2919 15 R r NN cord-010119-t1x9gknd 2919 16 2 2 CD cord-010119-t1x9gknd 2919 17 5 5 CD cord-010119-t1x9gknd 2919 18 0.92 0.92 CD cord-010119-t1x9gknd 2919 19 , , , cord-010119-t1x9gknd 2919 20 confirming confirm VBG cord-010119-t1x9gknd 2919 21 the the DT cord-010119-t1x9gknd 2919 22 findings finding NNS cord-010119-t1x9gknd 2919 23 in in IN cord-010119-t1x9gknd 2919 24 the the DT cord-010119-t1x9gknd 2919 25 first first JJ cord-010119-t1x9gknd 2919 26 data data NN cord-010119-t1x9gknd 2919 27 analysis analysis NN cord-010119-t1x9gknd 2919 28 . . . cord-010119-t1x9gknd 2920 1 The the DT cord-010119-t1x9gknd 2920 2 blood blood NN cord-010119-t1x9gknd 2920 3 volumes volume NNS cord-010119-t1x9gknd 2920 4 processed process VBN cord-010119-t1x9gknd 2920 5 and and CC cord-010119-t1x9gknd 2920 6 patient patient JJ cord-010119-t1x9gknd 2920 7 time time NN cord-010119-t1x9gknd 2920 8 on on IN cord-010119-t1x9gknd 2920 9 the the DT cord-010119-t1x9gknd 2920 10 machine machine NN cord-010119-t1x9gknd 2920 11 decreased decrease VBD cord-010119-t1x9gknd 2920 12 substantially substantially RB cord-010119-t1x9gknd 2920 13 , , , cord-010119-t1x9gknd 2920 14 with with IN cord-010119-t1x9gknd 2920 15 some some DT cord-010119-t1x9gknd 2920 16 patients patient NNS cord-010119-t1x9gknd 2920 17 only only RB cord-010119-t1x9gknd 2920 18 needing need VBG cord-010119-t1x9gknd 2920 19 2 2 CD cord-010119-t1x9gknd 2920 20 hours hour NNS cord-010119-t1x9gknd 2920 21 or or CC cord-010119-t1x9gknd 2920 22 less less JJR cord-010119-t1x9gknd 2920 23 to to TO cord-010119-t1x9gknd 2920 24 achieve achieve VB cord-010119-t1x9gknd 2920 25 their -PRON- PRP$ cord-010119-t1x9gknd 2920 26 target target NN cord-010119-t1x9gknd 2920 27 dose dose NN cord-010119-t1x9gknd 2920 28 . . . cord-010119-t1x9gknd 2921 1 Nurses nurse NNS cord-010119-t1x9gknd 2921 2 and and CC cord-010119-t1x9gknd 2921 3 lab lab VB cord-010119-t1x9gknd 2921 4 medical medical JJ cord-010119-t1x9gknd 2921 5 technologists technologist NNS cord-010119-t1x9gknd 2921 6 have have VBP cord-010119-t1x9gknd 2921 7 seen see VBN cord-010119-t1x9gknd 2921 8 a a DT cord-010119-t1x9gknd 2921 9 dramatic dramatic JJ cord-010119-t1x9gknd 2921 10 change change NN cord-010119-t1x9gknd 2921 11 in in IN cord-010119-t1x9gknd 2921 12 their -PRON- PRP$ cord-010119-t1x9gknd 2921 13 workflow workflow NN cord-010119-t1x9gknd 2921 14 . . . cord-010119-t1x9gknd 2922 1 The the DT cord-010119-t1x9gknd 2922 2 number number NN cord-010119-t1x9gknd 2922 3 of of IN cord-010119-t1x9gknd 2922 4 bags bag NNS cord-010119-t1x9gknd 2922 5 to to IN cord-010119-t1x9gknd 2922 6 process process NN cord-010119-t1x9gknd 2922 7 has have VBZ cord-010119-t1x9gknd 2922 8 dropped drop VBN cord-010119-t1x9gknd 2922 9 for for IN cord-010119-t1x9gknd 2922 10 the the DT cord-010119-t1x9gknd 2922 11 lab lab NN cord-010119-t1x9gknd 2922 12 , , , cord-010119-t1x9gknd 2922 13 with with IN cord-010119-t1x9gknd 2922 14 the the DT cord-010119-t1x9gknd 2922 15 consequent consequent JJ cord-010119-t1x9gknd 2922 16 freezer freezer NN cord-010119-t1x9gknd 2922 17 space space NN cord-010119-t1x9gknd 2922 18 savings saving NNS cord-010119-t1x9gknd 2922 19 and and CC cord-010119-t1x9gknd 2922 20 the the DT cord-010119-t1x9gknd 2922 21 shorter short JJR cord-010119-t1x9gknd 2922 22 collection collection NN cord-010119-t1x9gknd 2922 23 times time NNS cord-010119-t1x9gknd 2922 24 allowing allow VBG cord-010119-t1x9gknd 2922 25 the the DT cord-010119-t1x9gknd 2922 26 lab lab NN cord-010119-t1x9gknd 2922 27 medical medical JJ cord-010119-t1x9gknd 2922 28 technologists technologist NNS cord-010119-t1x9gknd 2922 29 to to TO cord-010119-t1x9gknd 2922 30 finish finish VB cord-010119-t1x9gknd 2922 31 with with IN cord-010119-t1x9gknd 2922 32 their -PRON- PRP$ cord-010119-t1x9gknd 2922 33 work work NN cord-010119-t1x9gknd 2922 34 earlier early RBR cord-010119-t1x9gknd 2922 35 in in IN cord-010119-t1x9gknd 2922 36 the the DT cord-010119-t1x9gknd 2922 37 day day NN cord-010119-t1x9gknd 2922 38 . . . cord-010119-t1x9gknd 2923 1 All all RB cord-010119-t1x9gknd 2923 2 in in IN cord-010119-t1x9gknd 2923 3 all all DT cord-010119-t1x9gknd 2923 4 , , , cord-010119-t1x9gknd 2923 5 implementation implementation NN cord-010119-t1x9gknd 2923 6 of of IN cord-010119-t1x9gknd 2923 7 this this DT cord-010119-t1x9gknd 2923 8 PA PA NNP cord-010119-t1x9gknd 2923 9 has have VBZ cord-010119-t1x9gknd 2923 10 produced produce VBN cord-010119-t1x9gknd 2923 11 huge huge JJ cord-010119-t1x9gknd 2923 12 increases increase NNS cord-010119-t1x9gknd 2923 13 in in IN cord-010119-t1x9gknd 2923 14 patient patient NN cord-010119-t1x9gknd 2923 15 and and CC cord-010119-t1x9gknd 2923 16 provider provider NN cord-010119-t1x9gknd 2923 17 satisfaction satisfaction NN cord-010119-t1x9gknd 2923 18 . . . cord-010119-t1x9gknd 2924 1 Important important JJ cord-010119-t1x9gknd 2924 2 factors factor NNS cord-010119-t1x9gknd 2924 3 that that WDT cord-010119-t1x9gknd 2924 4 likely likely RB cord-010119-t1x9gknd 2924 5 contributed contribute VBD cord-010119-t1x9gknd 2924 6 to to IN cord-010119-t1x9gknd 2924 7 the the DT cord-010119-t1x9gknd 2924 8 success success NN cord-010119-t1x9gknd 2924 9 of of IN cord-010119-t1x9gknd 2924 10 the the DT cord-010119-t1x9gknd 2924 11 protocol protocol NN cord-010119-t1x9gknd 2924 12 included include VBD cord-010119-t1x9gknd 2924 13 the the DT cord-010119-t1x9gknd 2924 14 precision precision NN cord-010119-t1x9gknd 2924 15 and and CC cord-010119-t1x9gknd 2924 16 consistency consistency NN cord-010119-t1x9gknd 2924 17 of of IN cord-010119-t1x9gknd 2924 18 the the DT cord-010119-t1x9gknd 2924 19 AIM AIM NNP cord-010119-t1x9gknd 2924 20 system system NN cord-010119-t1x9gknd 2924 21 of of IN cord-010119-t1x9gknd 2924 22 the the DT cord-010119-t1x9gknd 2924 23 apheresis apheresis NN cord-010119-t1x9gknd 2924 24 device device NN cord-010119-t1x9gknd 2924 25 , , , cord-010119-t1x9gknd 2924 26 as as RB cord-010119-t1x9gknd 2924 27 well well RB cord-010119-t1x9gknd 2924 28 as as IN cord-010119-t1x9gknd 2924 29 the the DT cord-010119-t1x9gknd 2924 30 small small JJ cord-010119-t1x9gknd 2924 31 number number NN cord-010119-t1x9gknd 2924 32 of of IN cord-010119-t1x9gknd 2924 33 nurses nurse NNS cord-010119-t1x9gknd 2924 34 ( ( -LRB- cord-010119-t1x9gknd 2924 35 1 1 CD cord-010119-t1x9gknd 2924 36 - - SYM cord-010119-t1x9gknd 2924 37 2 2 CD cord-010119-t1x9gknd 2924 38 ) ) -RRB- cord-010119-t1x9gknd 2924 39 who who WP cord-010119-t1x9gknd 2924 40 performed perform VBD cord-010119-t1x9gknd 2924 41 the the DT cord-010119-t1x9gknd 2924 42 procedures procedure NNS cord-010119-t1x9gknd 2924 43 , , , cord-010119-t1x9gknd 2924 44 resulting result VBG cord-010119-t1x9gknd 2924 45 in in IN cord-010119-t1x9gknd 2924 46 less less JJR cord-010119-t1x9gknd 2924 47 variability variability NN cord-010119-t1x9gknd 2924 48 . . . cord-010119-t1x9gknd 2925 1 The the DT cord-010119-t1x9gknd 2925 2 economic economic JJ cord-010119-t1x9gknd 2925 3 impact impact NN cord-010119-t1x9gknd 2925 4 of of IN cord-010119-t1x9gknd 2925 5 this this DT cord-010119-t1x9gknd 2925 6 PA PA NNP cord-010119-t1x9gknd 2925 7 has have VBZ cord-010119-t1x9gknd 2925 8 not not RB cord-010119-t1x9gknd 2925 9 been be VBN cord-010119-t1x9gknd 2925 10 quantified quantify VBN cord-010119-t1x9gknd 2925 11 , , , cord-010119-t1x9gknd 2925 12 but but CC cord-010119-t1x9gknd 2925 13 might may MD cord-010119-t1x9gknd 2925 14 be be VB cord-010119-t1x9gknd 2925 15 an an DT cord-010119-t1x9gknd 2925 16 interesting interesting JJ cord-010119-t1x9gknd 2925 17 area area NN cord-010119-t1x9gknd 2925 18 for for IN cord-010119-t1x9gknd 2925 19 future future JJ cord-010119-t1x9gknd 2925 20 studies study NNS cord-010119-t1x9gknd 2925 21 . . . cord-010119-t1x9gknd 2926 1 Background Background NNP cord-010119-t1x9gknd 2926 2 / / SYM cord-010119-t1x9gknd 2926 3 Case Case NNP cord-010119-t1x9gknd 2926 4 Studies Studies NNPS cord-010119-t1x9gknd 2926 5 : : : cord-010119-t1x9gknd 2926 6 ZarzioV ZarzioV NNP cord-010119-t1x9gknd 2926 7 R r NN cord-010119-t1x9gknd 2926 8 , , , cord-010119-t1x9gknd 2926 9 a a DT cord-010119-t1x9gknd 2926 10 biosimilar biosimilar NNP cord-010119-t1x9gknd 2926 11 granulocyte granulocyte NN cord-010119-t1x9gknd 2926 12 colonystimulating colonystimulating NN cord-010119-t1x9gknd 2926 13 factor factor NN cord-010119-t1x9gknd 2926 14 ( ( -LRB- cord-010119-t1x9gknd 2926 15 G G NNP cord-010119-t1x9gknd 2926 16 - - HYPH cord-010119-t1x9gknd 2926 17 CSF CSF NNP cord-010119-t1x9gknd 2926 18 ) ) -RRB- cord-010119-t1x9gknd 2926 19 has have VBZ cord-010119-t1x9gknd 2926 20 recently recently RB cord-010119-t1x9gknd 2926 21 been be VBN cord-010119-t1x9gknd 2926 22 introduced introduce VBN cord-010119-t1x9gknd 2926 23 into into IN cord-010119-t1x9gknd 2926 24 clinical clinical JJ cord-010119-t1x9gknd 2926 25 practice practice NN cord-010119-t1x9gknd 2926 26 . . . cord-010119-t1x9gknd 2927 1 Its -PRON- PRP$ cord-010119-t1x9gknd 2927 2 use use NN cord-010119-t1x9gknd 2927 3 has have VBZ cord-010119-t1x9gknd 2927 4 stimulated stimulate VBN cord-010119-t1x9gknd 2927 5 a a DT cord-010119-t1x9gknd 2927 6 certain certain JJ cord-010119-t1x9gknd 2927 7 debate debate NN cord-010119-t1x9gknd 2927 8 regarding regard VBG cord-010119-t1x9gknd 2927 9 their -PRON- PRP$ cord-010119-t1x9gknd 2927 10 possible possible JJ cord-010119-t1x9gknd 2927 11 less less JJR cord-010119-t1x9gknd 2927 12 efficacy efficacy NN cord-010119-t1x9gknd 2927 13 and and CC cord-010119-t1x9gknd 2927 14 security security NN cord-010119-t1x9gknd 2927 15 on on IN cord-010119-t1x9gknd 2927 16 CD341 cd341 NN cord-010119-t1x9gknd 2927 17 mobilization mobilization NN cord-010119-t1x9gknd 2927 18 . . . cord-010119-t1x9gknd 2928 1 The the DT cord-010119-t1x9gknd 2928 2 aim aim NN cord-010119-t1x9gknd 2928 3 of of IN cord-010119-t1x9gknd 2928 4 this this DT cord-010119-t1x9gknd 2928 5 study study NN cord-010119-t1x9gknd 2928 6 is be VBZ cord-010119-t1x9gknd 2928 7 to to TO cord-010119-t1x9gknd 2928 8 evaluate evaluate VB cord-010119-t1x9gknd 2928 9 if if IN cord-010119-t1x9gknd 2928 10 there there EX cord-010119-t1x9gknd 2928 11 are be VBP cord-010119-t1x9gknd 2928 12 differences difference NNS cord-010119-t1x9gknd 2928 13 between between IN cord-010119-t1x9gknd 2928 14 good good JJ cord-010119-t1x9gknd 2928 15 and and CC cord-010119-t1x9gknd 2928 16 bad bad JJ cord-010119-t1x9gknd 2928 17 mobilizers mobilizer NNS cord-010119-t1x9gknd 2928 18 and and CC cord-010119-t1x9gknd 2928 19 assess assess VB cord-010119-t1x9gknd 2928 20 the the DT cord-010119-t1x9gknd 2928 21 need need NN cord-010119-t1x9gknd 2928 22 for for IN cord-010119-t1x9gknd 2928 23 plerixafor plerixafor NN cord-010119-t1x9gknd 2928 24 when when WRB cord-010119-t1x9gknd 2928 25 a a DT cord-010119-t1x9gknd 2928 26 biosimilar biosimilar NN cord-010119-t1x9gknd 2928 27 as as IN cord-010119-t1x9gknd 2928 28 G G NNP cord-010119-t1x9gknd 2928 29 - - HYPH cord-010119-t1x9gknd 2928 30 CSF CSF NNP cord-010119-t1x9gknd 2928 31 is be VBZ cord-010119-t1x9gknd 2928 32 used use VBN cord-010119-t1x9gknd 2928 33 . . . cord-010119-t1x9gknd 2929 1 Study Study NNP cord-010119-t1x9gknd 2929 2 Design Design NNP cord-010119-t1x9gknd 2929 3 / / SYM cord-010119-t1x9gknd 2929 4 Method method NN cord-010119-t1x9gknd 2929 5 : : : cord-010119-t1x9gknd 2929 6 We -PRON- PRP cord-010119-t1x9gknd 2929 7 retrospectively retrospectively RB cord-010119-t1x9gknd 2929 8 evaluated evaluate VBD cord-010119-t1x9gknd 2929 9 autologous autologous JJ cord-010119-t1x9gknd 2929 10 mobilization mobilization NN cord-010119-t1x9gknd 2929 11 processes process NNS cord-010119-t1x9gknd 2929 12 performed perform VBN cord-010119-t1x9gknd 2929 13 between between IN cord-010119-t1x9gknd 2929 14 June June NNP cord-010119-t1x9gknd 2929 15 2015 2015 CD cord-010119-t1x9gknd 2929 16 and and CC cord-010119-t1x9gknd 2929 17 March March NNP cord-010119-t1x9gknd 2929 18 2016 2016 CD cord-010119-t1x9gknd 2929 19 . . . cord-010119-t1x9gknd 2930 1 Patients patient NNS cord-010119-t1x9gknd 2930 2 ( ( -LRB- cord-010119-t1x9gknd 2930 3 n525 n525 NNP cord-010119-t1x9gknd 2930 4 ) ) -RRB- cord-010119-t1x9gknd 2930 5 evaluated evaluate VBN cord-010119-t1x9gknd 2930 6 were be VBD cord-010119-t1x9gknd 2930 7 diagnosed diagnose VBN cord-010119-t1x9gknd 2930 8 with with IN cord-010119-t1x9gknd 2930 9 malignant malignant JJ cord-010119-t1x9gknd 2930 10 lymphoma lymphoma NN cord-010119-t1x9gknd 2930 11 ( ( -LRB- cord-010119-t1x9gknd 2930 12 n515 n515 NNS cord-010119-t1x9gknd 2930 13 ) ) -RRB- cord-010119-t1x9gknd 2930 14 , , , cord-010119-t1x9gknd 2930 15 multiple multiple JJ cord-010119-t1x9gknd 2930 16 myeloma myeloma NN cord-010119-t1x9gknd 2930 17 ( ( -LRB- cord-010119-t1x9gknd 2930 18 n59 n59 NN cord-010119-t1x9gknd 2930 19 ) ) -RRB- cord-010119-t1x9gknd 2930 20 and and CC cord-010119-t1x9gknd 2930 21 Primary Primary NNP cord-010119-t1x9gknd 2930 22 Amyloidosis Amyloidosis NNP cord-010119-t1x9gknd 2930 23 ( ( -LRB- cord-010119-t1x9gknd 2930 24 n51 n51 NNP cord-010119-t1x9gknd 2930 25 ) ) -RRB- cord-010119-t1x9gknd 2930 26 and and CC cord-010119-t1x9gknd 2930 27 were be VBD cord-010119-t1x9gknd 2930 28 mobilized mobilize VBN cord-010119-t1x9gknd 2930 29 according accord VBG cord-010119-t1x9gknd 2930 30 to to IN cord-010119-t1x9gknd 2930 31 standard standard JJ cord-010119-t1x9gknd 2930 32 protocols protocol NNS cord-010119-t1x9gknd 2930 33 . . . cord-010119-t1x9gknd 2931 1 Collection collection NN cord-010119-t1x9gknd 2931 2 CD341 cd341 NN cord-010119-t1x9gknd 2931 3 cellularity cellularity NN cord-010119-t1x9gknd 2931 4 target target NN cord-010119-t1x9gknd 2931 5 was be VBD cord-010119-t1x9gknd 2931 6 established establish VBN cord-010119-t1x9gknd 2931 7 ! ! . cord-010119-t1x9gknd 2932 1 2x10E6 2x10e6 CD cord-010119-t1x9gknd 2932 2 / / SYM cord-010119-t1x9gknd 2932 3 kg kg NNS cord-010119-t1x9gknd 2932 4 . . . cord-010119-t1x9gknd 2933 1 Two two CD cord-010119-t1x9gknd 2933 2 groups group NNS cord-010119-t1x9gknd 2933 3 , , , cord-010119-t1x9gknd 2933 4 good good JJ cord-010119-t1x9gknd 2933 5 and and CC cord-010119-t1x9gknd 2933 6 bad bad JJ cord-010119-t1x9gknd 2933 7 mobilizers mobilizer NNS cord-010119-t1x9gknd 2933 8 , , , cord-010119-t1x9gknd 2933 9 have have VBP cord-010119-t1x9gknd 2933 10 been be VBN cord-010119-t1x9gknd 2933 11 determined determine VBN cord-010119-t1x9gknd 2933 12 . . . cord-010119-t1x9gknd 2934 1 Predictors predictor NNS cord-010119-t1x9gknd 2934 2 of of IN cord-010119-t1x9gknd 2934 3 unsuccessful unsuccessful JJ cord-010119-t1x9gknd 2934 4 mobilization mobilization NN cord-010119-t1x9gknd 2934 5 were be VBD cord-010119-t1x9gknd 2934 6 defined define VBN cord-010119-t1x9gknd 2934 7 by by IN cord-010119-t1x9gknd 2934 8 > > XX cord-010119-t1x9gknd 2934 9 65 65 CD cord-010119-t1x9gknd 2934 10 years year NNS cord-010119-t1x9gknd 2934 11 old old JJ cord-010119-t1x9gknd 2934 12 , , , cord-010119-t1x9gknd 2934 13 previous previous JJ cord-010119-t1x9gknd 2934 14 fludarabine fludarabine NN cord-010119-t1x9gknd 2934 15 , , , cord-010119-t1x9gknd 2934 16 lenalidomide lenalidomide NN cord-010119-t1x9gknd 2934 17 , , , cord-010119-t1x9gknd 2934 18 or or CC cord-010119-t1x9gknd 2934 19 bendamustine bendamustine JJ cord-010119-t1x9gknd 2934 20 treatments treatment NNS cord-010119-t1x9gknd 2934 21 or or CC cord-010119-t1x9gknd 2934 22 ! ! . cord-010119-t1x9gknd 2935 1 2 2 LS cord-010119-t1x9gknd 2936 1 previous previous JJ cord-010119-t1x9gknd 2936 2 regimens regimen NNS cord-010119-t1x9gknd 2936 3 , , , cord-010119-t1x9gknd 2936 4 present present JJ cord-010119-t1x9gknd 2936 5 peripheral peripheral JJ cord-010119-t1x9gknd 2936 6 cytopenias cytopenia NNS cord-010119-t1x9gknd 2936 7 , , , cord-010119-t1x9gknd 2936 8 active active JJ cord-010119-t1x9gknd 2936 9 disease disease NN cord-010119-t1x9gknd 2936 10 and and CC cord-010119-t1x9gknd 2936 11 previous previous JJ cord-010119-t1x9gknd 2936 12 mobilization mobilization NN cord-010119-t1x9gknd 2936 13 failure failure NN cord-010119-t1x9gknd 2936 14 . . . cord-010119-t1x9gknd 2937 1 Mann Mann NNP cord-010119-t1x9gknd 2937 2 - - HYPH cord-010119-t1x9gknd 2937 3 Whitney Whitney NNP cord-010119-t1x9gknd 2937 4 U U NNP cord-010119-t1x9gknd 2937 5 test test NN cord-010119-t1x9gknd 2937 6 was be VBD cord-010119-t1x9gknd 2937 7 used use VBN cord-010119-t1x9gknd 2937 8 to to TO cord-010119-t1x9gknd 2937 9 compare compare VB cord-010119-t1x9gknd 2937 10 means mean NNS cord-010119-t1x9gknd 2937 11 and and CC cord-010119-t1x9gknd 2937 12 comparisons comparison NNS cord-010119-t1x9gknd 2937 13 of of IN cord-010119-t1x9gknd 2937 14 medians median NNS cord-010119-t1x9gknd 2937 15 were be VBD cord-010119-t1x9gknd 2937 16 performed perform VBN cord-010119-t1x9gknd 2937 17 by by IN cord-010119-t1x9gknd 2937 18 the the DT cord-010119-t1x9gknd 2937 19 median median JJ cord-010119-t1x9gknd 2937 20 test test NN cord-010119-t1x9gknd 2937 21 . . . cord-010119-t1x9gknd 2938 1 CD341 CD341 NNP cord-010119-t1x9gknd 2938 2 count count NN cord-010119-t1x9gknd 2938 3 was be VBD cord-010119-t1x9gknd 2938 4 performed perform VBN cord-010119-t1x9gknd 2938 5 according accord VBG cord-010119-t1x9gknd 2938 6 ISHAGE ISHAGE NNP cord-010119-t1x9gknd 2938 7 protocol protocol NN cord-010119-t1x9gknd 2938 8 . . . cord-010119-t1x9gknd 2939 1 Adverse adverse JJ cord-010119-t1x9gknd 2939 2 events event NNS cord-010119-t1x9gknd 2939 3 ( ( -LRB- cord-010119-t1x9gknd 2939 4 AE AE NNP cord-010119-t1x9gknd 2939 5 ) ) -RRB- cord-010119-t1x9gknd 2939 6 were be VBD cord-010119-t1x9gknd 2939 7 analysed analyse VBN cord-010119-t1x9gknd 2939 8 according accord VBG cord-010119-t1x9gknd 2939 9 to to IN cord-010119-t1x9gknd 2939 10 CTCAE CTCAE NNP cord-010119-t1x9gknd 2939 11 v4.0 v4.0 NN cord-010119-t1x9gknd 2939 12 . . . cord-010119-t1x9gknd 2940 1 Results/ Results/ . cord-010119-t1x9gknd 2941 1 Finding find VBG cord-010119-t1x9gknd 2941 2 : : : cord-010119-t1x9gknd 2941 3 The the DT cord-010119-t1x9gknd 2941 4 media medium NNS cord-010119-t1x9gknd 2941 5 ( ( -LRB- cord-010119-t1x9gknd 2941 6 range range NN cord-010119-t1x9gknd 2941 7 ) ) -RRB- cord-010119-t1x9gknd 2941 8 general general JJ cord-010119-t1x9gknd 2941 9 collection collection NN cord-010119-t1x9gknd 2941 10 parameters parameter NNS cord-010119-t1x9gknd 2941 11 were be VBD cord-010119-t1x9gknd 2941 12 : : : cord-010119-t1x9gknd 2941 13 CD341 CD341 NNP cord-010119-t1x9gknd 2941 14 ( ( -LRB- cord-010119-t1x9gknd 2941 15 day day NN cord-010119-t1x9gknd 2941 16 5 5 CD cord-010119-t1x9gknd 2941 17 ) ) -RRB- cord-010119-t1x9gknd 2941 18 27.50 27.50 CD cord-010119-t1x9gknd 2941 19 / / SYM cord-010119-t1x9gknd 2941 20 mL ml NN cord-010119-t1x9gknd 2941 21 ( ( -LRB- cord-010119-t1x9gknd 2941 22 4.5 4.5 CD cord-010119-t1x9gknd 2941 23 - - SYM cord-010119-t1x9gknd 2941 24 157.5 157.5 CD cord-010119-t1x9gknd 2941 25 / / SYM cord-010119-t1x9gknd 2941 26 mL ml NN cord-010119-t1x9gknd 2941 27 ) ) -RRB- cord-010119-t1x9gknd 2941 28 , , , cord-010119-t1x9gknd 2941 29 blood blood NN cord-010119-t1x9gknd 2941 30 volume volume NN cord-010119-t1x9gknd 2941 31 processed process VBN cord-010119-t1x9gknd 2941 32 23204mL 23204ml CD cord-010119-t1x9gknd 2941 33 ( ( -LRB- cord-010119-t1x9gknd 2941 34 9718 9718 CD cord-010119-t1x9gknd 2941 35 - - SYM cord-010119-t1x9gknd 2941 36 39618mL 39618ml CD cord-010119-t1x9gknd 2941 37 ) ) -RRB- cord-010119-t1x9gknd 2941 38 and and CC cord-010119-t1x9gknd 2941 39 4.96 4.96 CD cord-010119-t1x9gknd 2941 40 ( ( -LRB- cord-010119-t1x9gknd 2941 41 2 2 CD cord-010119-t1x9gknd 2941 42 - - SYM cord-010119-t1x9gknd 2941 43 7.30 7.30 CD cord-010119-t1x9gknd 2941 44 ) ) -RRB- cord-010119-t1x9gknd 2941 45 exchanged exchange VBD cord-010119-t1x9gknd 2941 46 volemias volemia NNS cord-010119-t1x9gknd 2941 47 . . . cord-010119-t1x9gknd 2942 1 Seventeen seventeen CD cord-010119-t1x9gknd 2942 2 patients patient NNS cord-010119-t1x9gknd 2942 3 were be VBD cord-010119-t1x9gknd 2942 4 considered consider VBN cord-010119-t1x9gknd 2942 5 bad bad JJ cord-010119-t1x9gknd 2942 6 mobilizers mobilizer NNS cord-010119-t1x9gknd 2942 7 , , , cord-010119-t1x9gknd 2942 8 7 7 CD cord-010119-t1x9gknd 2942 9 needed need VBD cord-010119-t1x9gknd 2942 10 plerixafor plerixafor NN cord-010119-t1x9gknd 2942 11 and and CC cord-010119-t1x9gknd 2942 12 5 5 CD cord-010119-t1x9gknd 2942 13 had have VBD cord-010119-t1x9gknd 2942 14 to to TO cord-010119-t1x9gknd 2942 15 undergone undergo VBN cord-010119-t1x9gknd 2942 16 a a DT cord-010119-t1x9gknd 2942 17 collection collection NN cord-010119-t1x9gknd 2942 18 procedure procedure NN cord-010119-t1x9gknd 2942 19 twice twice RB cord-010119-t1x9gknd 2942 20 . . . cord-010119-t1x9gknd 2943 1 There there EX cord-010119-t1x9gknd 2943 2 were be VBD cord-010119-t1x9gknd 2943 3 statistically statistically RB cord-010119-t1x9gknd 2943 4 significant significant JJ cord-010119-t1x9gknd 2943 5 differences difference NNS cord-010119-t1x9gknd 2943 6 between between IN cord-010119-t1x9gknd 2943 7 both both DT cord-010119-t1x9gknd 2943 8 groups group NNS cord-010119-t1x9gknd 2943 9 on on IN cord-010119-t1x9gknd 2943 10 mobilization mobilization NN cord-010119-t1x9gknd 2943 11 characteristics characteristic NNS cord-010119-t1x9gknd 2943 12 and and CC cord-010119-t1x9gknd 2943 13 product product NN cord-010119-t1x9gknd 2943 14 cellularity cellularity NN cord-010119-t1x9gknd 2943 15 [ [ -LRB- cord-010119-t1x9gknd 2943 16 mean mean JJ cord-010119-t1x9gknd 2943 17 ( ( -LRB- cord-010119-t1x9gknd 2943 18 SD SD NNP cord-010119-t1x9gknd 2943 19 ) ) -RRB- cord-010119-t1x9gknd 2943 20 ) ) -RRB- cord-010119-t1x9gknd 2943 21 ; ; : cord-010119-t1x9gknd 2944 1 p50.071 p50.071 NNP cord-010119-t1x9gknd 2944 2 ] ] -RRB- cord-010119-t1x9gknd 2944 3 . . . cord-010119-t1x9gknd 2945 1 There there EX cord-010119-t1x9gknd 2945 2 were be VBD cord-010119-t1x9gknd 2945 3 no no DT cord-010119-t1x9gknd 2945 4 significant significant JJ cord-010119-t1x9gknd 2945 5 differences difference NNS cord-010119-t1x9gknd 2945 6 on on IN cord-010119-t1x9gknd 2945 7 mobilization mobilization NN cord-010119-t1x9gknd 2945 8 characteristics characteristic NNS cord-010119-t1x9gknd 2945 9 and and CC cord-010119-t1x9gknd 2945 10 product product NN cord-010119-t1x9gknd 2945 11 cellularity cellularity NN cord-010119-t1x9gknd 2945 12 between between IN cord-010119-t1x9gknd 2945 13 both both DT cord-010119-t1x9gknd 2945 14 groups group NNS cord-010119-t1x9gknd 2945 15 . . . cord-010119-t1x9gknd 2946 1 Five five CD cord-010119-t1x9gknd 2946 2 mobilization mobilization NN cord-010119-t1x9gknd 2946 3 AE AE NNP cord-010119-t1x9gknd 2946 4 were be VBD cord-010119-t1x9gknd 2946 5 observed observe VBN cord-010119-t1x9gknd 2946 6 [ [ -LRB- cord-010119-t1x9gknd 2946 7 muscle muscle NN cord-010119-t1x9gknd 2946 8 pain pain NN cord-010119-t1x9gknd 2946 9 ( ( -LRB- cord-010119-t1x9gknd 2946 10 n52 n52 NNP cord-010119-t1x9gknd 2946 11 ) ) -RRB- cord-010119-t1x9gknd 2946 12 , , , cord-010119-t1x9gknd 2946 13 fever fever NN cord-010119-t1x9gknd 2946 14 ( ( -LRB- cord-010119-t1x9gknd 2946 15 n52 n52 NNP cord-010119-t1x9gknd 2946 16 ) ) -RRB- cord-010119-t1x9gknd 2946 17 and and CC cord-010119-t1x9gknd 2946 18 flu flu NN cord-010119-t1x9gknd 2946 19 syndrome syndrome NN cord-010119-t1x9gknd 2946 20 ; ; : cord-010119-t1x9gknd 2946 21 all all DT cord-010119-t1x9gknd 2946 22 grade grade NN cord-010119-t1x9gknd 2946 23 1 1 CD cord-010119-t1x9gknd 2946 24 ] ] -RRB- cord-010119-t1x9gknd 2946 25 . . . cord-010119-t1x9gknd 2947 1 Two two CD cord-010119-t1x9gknd 2947 2 patients patient NNS cord-010119-t1x9gknd 2947 3 could could MD cord-010119-t1x9gknd 2947 4 not not RB cord-010119-t1x9gknd 2947 5 undergo undergo VB cord-010119-t1x9gknd 2947 6 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 2947 7 stem stem NN cord-010119-t1x9gknd 2947 8 cell cell NN cord-010119-t1x9gknd 2947 9 transplantation transplantation NN cord-010119-t1x9gknd 2947 10 due due JJ cord-010119-t1x9gknd 2947 11 low low JJ cord-010119-t1x9gknd 2947 12 CD341 cd341 NN cord-010119-t1x9gknd 2947 13 cellularity cellularity NN cord-010119-t1x9gknd 2947 14 . . . cord-010119-t1x9gknd 2948 1 Conclusion conclusion NN cord-010119-t1x9gknd 2948 2 : : : cord-010119-t1x9gknd 2949 1 There there EX cord-010119-t1x9gknd 2949 2 are be VBP cord-010119-t1x9gknd 2949 3 differences difference NNS cord-010119-t1x9gknd 2949 4 between between IN cord-010119-t1x9gknd 2949 5 products product NNS cord-010119-t1x9gknd 2949 6 collected collect VBN cord-010119-t1x9gknd 2949 7 from from IN cord-010119-t1x9gknd 2949 8 the the DT cord-010119-t1x9gknd 2949 9 good good JJ cord-010119-t1x9gknd 2949 10 mobilizer mobilizer NN cord-010119-t1x9gknd 2949 11 ( ( -LRB- cord-010119-t1x9gknd 2949 12 rich rich JJ cord-010119-t1x9gknd 2949 13 in in IN cord-010119-t1x9gknd 2949 14 GM GM NNP cord-010119-t1x9gknd 2949 15 and and CC cord-010119-t1x9gknd 2949 16 CD34 CD34 NNP cord-010119-t1x9gknd 2949 17 ) ) -RRB- cord-010119-t1x9gknd 2949 18 versus versus IN cord-010119-t1x9gknd 2949 19 poor poor JJ cord-010119-t1x9gknd 2949 20 mobilizer mobilizer NN cord-010119-t1x9gknd 2949 21 ( ( -LRB- cord-010119-t1x9gknd 2949 22 with with IN cord-010119-t1x9gknd 2949 23 plerixafor plerixafor NN cord-010119-t1x9gknd 2949 24 ) ) -RRB- cord-010119-t1x9gknd 2949 25 rich rich JJ cord-010119-t1x9gknd 2949 26 in in IN cord-010119-t1x9gknd 2949 27 CN CN NNP cord-010119-t1x9gknd 2949 28 and and CC cord-010119-t1x9gknd 2949 29 CMN CMN NNP cord-010119-t1x9gknd 2949 30 . . . cord-010119-t1x9gknd 2950 1 The the DT cord-010119-t1x9gknd 2950 2 mobilization mobilization NN cord-010119-t1x9gknd 2950 3 with with IN cord-010119-t1x9gknd 2950 4 ZarzioV ZarzioV NNP cord-010119-t1x9gknd 2950 5 R r NN cord-010119-t1x9gknd 2950 6 could could MD cord-010119-t1x9gknd 2950 7 be be VB cord-010119-t1x9gknd 2950 8 smaller small JJR cord-010119-t1x9gknd 2950 9 than than IN cord-010119-t1x9gknd 2950 10 expected expect VBN cord-010119-t1x9gknd 2950 11 since since IN cord-010119-t1x9gknd 2950 12 there there EX cord-010119-t1x9gknd 2950 13 are be VBP cord-010119-t1x9gknd 2950 14 no no DT cord-010119-t1x9gknd 2950 15 significant significant JJ cord-010119-t1x9gknd 2950 16 differences difference NNS cord-010119-t1x9gknd 2950 17 if if IN cord-010119-t1x9gknd 2950 18 we -PRON- PRP cord-010119-t1x9gknd 2950 19 compare compare VBP cord-010119-t1x9gknd 2950 20 the the DT cord-010119-t1x9gknd 2950 21 good good JJ cord-010119-t1x9gknd 2950 22 mobilizers mobilizer NNS cord-010119-t1x9gknd 2950 23 versus versus IN cord-010119-t1x9gknd 2950 24 the the DT cord-010119-t1x9gknd 2950 25 bad bad JJ cord-010119-t1x9gknd 2950 26 mobilizers mobilizer NNS cord-010119-t1x9gknd 2950 27 although although IN cord-010119-t1x9gknd 2950 28 the the DT cord-010119-t1x9gknd 2950 29 number number NN cord-010119-t1x9gknd 2950 30 of of IN cord-010119-t1x9gknd 2950 31 cases case NNS cord-010119-t1x9gknd 2950 32 studied study VBN cord-010119-t1x9gknd 2950 33 can can MD cord-010119-t1x9gknd 2950 34 be be VB cord-010119-t1x9gknd 2950 35 limiting limit VBG cord-010119-t1x9gknd 2950 36 . . . cord-010119-t1x9gknd 2951 1 Background Background NNP cord-010119-t1x9gknd 2951 2 / / SYM cord-010119-t1x9gknd 2951 3 Case Case NNP cord-010119-t1x9gknd 2951 4 Studies Studies NNPS cord-010119-t1x9gknd 2951 5 : : : cord-010119-t1x9gknd 2951 6 Mesenchymal Mesenchymal NNS cord-010119-t1x9gknd 2951 7 stem stem VBP cord-010119-t1x9gknd 2951 8 cells cell NNS cord-010119-t1x9gknd 2951 9 ( ( -LRB- cord-010119-t1x9gknd 2951 10 MSCs msc NNS cord-010119-t1x9gknd 2951 11 ) ) -RRB- cord-010119-t1x9gknd 2951 12 have have VBP cord-010119-t1x9gknd 2951 13 been be VBN cord-010119-t1x9gknd 2951 14 widely widely RB cord-010119-t1x9gknd 2951 15 studied study VBN cord-010119-t1x9gknd 2951 16 and and CC cord-010119-t1x9gknd 2951 17 have have VBP cord-010119-t1x9gknd 2951 18 shown show VBN cord-010119-t1x9gknd 2951 19 beneficial beneficial JJ cord-010119-t1x9gknd 2951 20 effects effect NNS cord-010119-t1x9gknd 2951 21 on on IN cord-010119-t1x9gknd 2951 22 tissue tissue NN cord-010119-t1x9gknd 2951 23 regeneration regeneration NN cord-010119-t1x9gknd 2951 24 , , , cord-010119-t1x9gknd 2951 25 immunomodulation immunomodulation NN cord-010119-t1x9gknd 2951 26 , , , cord-010119-t1x9gknd 2951 27 and and CC cord-010119-t1x9gknd 2951 28 improvement improvement NN cord-010119-t1x9gknd 2951 29 of of IN cord-010119-t1x9gknd 2951 30 multiple multiple JJ cord-010119-t1x9gknd 2951 31 organ organ NN cord-010119-t1x9gknd 2951 32 failure failure NN cord-010119-t1x9gknd 2951 33 caused cause VBN cord-010119-t1x9gknd 2951 34 by by IN cord-010119-t1x9gknd 2951 35 infection infection NN cord-010119-t1x9gknd 2951 36 , , , cord-010119-t1x9gknd 2951 37 sepsis sepsis NN cord-010119-t1x9gknd 2951 38 , , , cord-010119-t1x9gknd 2951 39 and and CC cord-010119-t1x9gknd 2951 40 trauma trauma NN cord-010119-t1x9gknd 2951 41 . . . cord-010119-t1x9gknd 2952 1 However however RB cord-010119-t1x9gknd 2952 2 , , , cord-010119-t1x9gknd 2952 3 MSCs msc NNS cord-010119-t1x9gknd 2952 4 express express JJ cord-010119-t1x9gknd 2952 5 tissue tissue NN cord-010119-t1x9gknd 2952 6 factor factor NN cord-010119-t1x9gknd 2952 7 , , , cord-010119-t1x9gknd 2952 8 which which WDT cord-010119-t1x9gknd 2952 9 may may MD cord-010119-t1x9gknd 2952 10 be be VB cord-010119-t1x9gknd 2952 11 a a DT cord-010119-t1x9gknd 2952 12 risk risk NN cord-010119-t1x9gknd 2952 13 factor factor NN cord-010119-t1x9gknd 2952 14 for for IN cord-010119-t1x9gknd 2952 15 thrombosis thrombosis NN cord-010119-t1x9gknd 2952 16 especially especially RB cord-010119-t1x9gknd 2952 17 if if IN cord-010119-t1x9gknd 2952 18 administrated administrate VBN cord-010119-t1x9gknd 2952 19 systemically systemically RB cord-010119-t1x9gknd 2952 20 following follow VBG cord-010119-t1x9gknd 2952 21 trauma trauma NN cord-010119-t1x9gknd 2952 22 when when WRB cord-010119-t1x9gknd 2952 23 coagulopathies coagulopathie NNS cord-010119-t1x9gknd 2952 24 are be VBP cord-010119-t1x9gknd 2952 25 common common JJ cord-010119-t1x9gknd 2952 26 . . . cord-010119-t1x9gknd 2953 1 Before before IN cord-010119-t1x9gknd 2953 2 applying apply VBG cord-010119-t1x9gknd 2953 3 MSCs msc NNS cord-010119-t1x9gknd 2953 4 in in IN cord-010119-t1x9gknd 2953 5 a a DT cord-010119-t1x9gknd 2953 6 preclinical preclinical JJ cord-010119-t1x9gknd 2953 7 animal animal NN cord-010119-t1x9gknd 2953 8 model model NN cord-010119-t1x9gknd 2953 9 , , , cord-010119-t1x9gknd 2953 10 we -PRON- PRP cord-010119-t1x9gknd 2953 11 sought seek VBD cord-010119-t1x9gknd 2953 12 to to TO cord-010119-t1x9gknd 2953 13 determine determine VB cord-010119-t1x9gknd 2953 14 the the DT cord-010119-t1x9gknd 2953 15 procoagulant procoagulant JJ cord-010119-t1x9gknd 2953 16 properties property NNS cord-010119-t1x9gknd 2953 17 of of IN cord-010119-t1x9gknd 2953 18 rat rat NN cord-010119-t1x9gknd 2953 19 MSCs msc NNS cord-010119-t1x9gknd 2953 20 in in IN cord-010119-t1x9gknd 2953 21 vitro vitro FW cord-010119-t1x9gknd 2953 22 . . . cord-010119-t1x9gknd 2954 1 Study Study NNP cord-010119-t1x9gknd 2954 2 Design Design NNP cord-010119-t1x9gknd 2954 3 / / SYM cord-010119-t1x9gknd 2954 4 Methods method NNS cord-010119-t1x9gknd 2954 5 : : : cord-010119-t1x9gknd 2955 1 Bone bone NN cord-010119-t1x9gknd 2955 2 marrow marrow NN cord-010119-t1x9gknd 2955 3 and and CC cord-010119-t1x9gknd 2955 4 adipose adipose NN cord-010119-t1x9gknd 2955 5 derived derive VBN cord-010119-t1x9gknd 2955 6 MSCs mscs NN cord-010119-t1x9gknd 2955 7 ( ( -LRB- cord-010119-t1x9gknd 2955 8 BMSC BMSC NNP cord-010119-t1x9gknd 2955 9 and and CC cord-010119-t1x9gknd 2955 10 AMSC AMSC NNP cord-010119-t1x9gknd 2955 11 ) ) -RRB- cord-010119-t1x9gknd 2955 12 were be VBD cord-010119-t1x9gknd 2955 13 isolated isolate VBN cord-010119-t1x9gknd 2955 14 from from IN cord-010119-t1x9gknd 2955 15 bones bone NNS cord-010119-t1x9gknd 2955 16 ( ( -LRB- cord-010119-t1x9gknd 2955 17 femur femur NN cord-010119-t1x9gknd 2955 18 and and CC cord-010119-t1x9gknd 2955 19 tibia tibia NN cord-010119-t1x9gknd 2955 20 ) ) -RRB- cord-010119-t1x9gknd 2955 21 and and CC cord-010119-t1x9gknd 2955 22 visceral visceral JJ cord-010119-t1x9gknd 2955 23 fat fat JJ cord-010119-t1x9gknd 2955 24 tissue tissue NN cord-010119-t1x9gknd 2955 25 in in IN cord-010119-t1x9gknd 2955 26 normal normal JJ cord-010119-t1x9gknd 2955 27 young young JJ cord-010119-t1x9gknd 2955 28 Sprague Sprague NNP cord-010119-t1x9gknd 2955 29 Dawley Dawley NNP cord-010119-t1x9gknd 2955 30 rats rat NNS cord-010119-t1x9gknd 2955 31 respectively respectively RB cord-010119-t1x9gknd 2955 32 . . . cord-010119-t1x9gknd 2956 1 Both both DT cord-010119-t1x9gknd 2956 2 BMSCs bmsc NNS cord-010119-t1x9gknd 2956 3 and and CC cord-010119-t1x9gknd 2956 4 AMSCs amsc NNS cord-010119-t1x9gknd 2956 5 were be VBD cord-010119-t1x9gknd 2956 6 cultured cultured JJ cord-010119-t1x9gknd 2956 7 and and CC cord-010119-t1x9gknd 2956 8 passaged passaged JJ cord-010119-t1x9gknd 2956 9 using use VBG cord-010119-t1x9gknd 2956 10 DMEM DMEM NNP cord-010119-t1x9gknd 2956 11 medium medium NN cord-010119-t1x9gknd 2956 12 with with IN cord-010119-t1x9gknd 2956 13 20 20 CD cord-010119-t1x9gknd 2956 14 % % NN cord-010119-t1x9gknd 2956 15 fetal fetal JJ cord-010119-t1x9gknd 2956 16 bovine bovine JJ cord-010119-t1x9gknd 2956 17 serum serum NN cord-010119-t1x9gknd 2956 18 . . . cord-010119-t1x9gknd 2957 1 BMSC BMSC NNP cord-010119-t1x9gknd 2957 2 and and CC cord-010119-t1x9gknd 2957 3 AMSC AMSC NNP cord-010119-t1x9gknd 2957 4 at at IN cord-010119-t1x9gknd 2957 5 passage passage NN cord-010119-t1x9gknd 2957 6 2 2 CD cord-010119-t1x9gknd 2957 7 - - SYM cord-010119-t1x9gknd 2957 8 5 5 CD cord-010119-t1x9gknd 2957 9 were be VBD cord-010119-t1x9gknd 2957 10 used use VBN cord-010119-t1x9gknd 2957 11 in in IN cord-010119-t1x9gknd 2957 12 this this DT cord-010119-t1x9gknd 2957 13 study study NN cord-010119-t1x9gknd 2957 14 . . . cord-010119-t1x9gknd 2958 1 The the DT cord-010119-t1x9gknd 2958 2 tissue tissue NN cord-010119-t1x9gknd 2958 3 factor factor NN cord-010119-t1x9gknd 2958 4 expression expression NN cord-010119-t1x9gknd 2958 5 of of IN cord-010119-t1x9gknd 2958 6 MSCs msc NNS cord-010119-t1x9gknd 2958 7 was be VBD cord-010119-t1x9gknd 2958 8 determined determine VBN cord-010119-t1x9gknd 2958 9 by by IN cord-010119-t1x9gknd 2958 10 immunohistochemistry immunohistochemistry NN cord-010119-t1x9gknd 2958 11 . . . cord-010119-t1x9gknd 2959 1 Citrated citrate VBN cord-010119-t1x9gknd 2959 2 whole whole JJ cord-010119-t1x9gknd 2959 3 blood blood NN cord-010119-t1x9gknd 2959 4 collected collect VBN cord-010119-t1x9gknd 2959 5 from from IN cord-010119-t1x9gknd 2959 6 normal normal JJ cord-010119-t1x9gknd 2959 7 rats rat NNS cord-010119-t1x9gknd 2959 8 was be VBD cord-010119-t1x9gknd 2959 9 treated treat VBN cord-010119-t1x9gknd 2959 10 with with IN cord-010119-t1x9gknd 2959 11 rat rat NN cord-010119-t1x9gknd 2959 12 BMSCs bmsc NNS cord-010119-t1x9gknd 2959 13 and and CC cord-010119-t1x9gknd 2959 14 AMSCs amsc NNS cord-010119-t1x9gknd 2959 15 at at IN cord-010119-t1x9gknd 2959 16 low low JJ cord-010119-t1x9gknd 2959 17 , , , cord-010119-t1x9gknd 2959 18 medium medium JJ cord-010119-t1x9gknd 2959 19 and and CC cord-010119-t1x9gknd 2959 20 high high JJ cord-010119-t1x9gknd 2959 21 doses dose NNS cord-010119-t1x9gknd 2959 22 ( ( -LRB- cord-010119-t1x9gknd 2959 23 1.5 1.5 CD cord-010119-t1x9gknd 2959 24 3 3 CD cord-010119-t1x9gknd 2959 25 10 10 CD cord-010119-t1x9gknd 2959 26 4 4 CD cord-010119-t1x9gknd 2959 27 /ml /ml CD cord-010119-t1x9gknd 2959 28 , , , cord-010119-t1x9gknd 2959 29 7 7 CD cord-010119-t1x9gknd 2959 30 3 3 CD cord-010119-t1x9gknd 2959 31 10 10 CD cord-010119-t1x9gknd 2959 32 4 4 CD cord-010119-t1x9gknd 2959 33 /ml /ml . cord-010119-t1x9gknd 2959 34 and and CC cord-010119-t1x9gknd 2959 35 1.5 1.5 CD cord-010119-t1x9gknd 2959 36 3 3 CD cord-010119-t1x9gknd 2959 37 10 10 CD cord-010119-t1x9gknd 2959 38 5 5 CD cord-010119-t1x9gknd 2959 39 /ml /ml . cord-010119-t1x9gknd 2959 40 respectively respectively RB cord-010119-t1x9gknd 2959 41 ) ) -RRB- cord-010119-t1x9gknd 2959 42 . . . cord-010119-t1x9gknd 2960 1 The the DT cord-010119-t1x9gknd 2960 2 prothrombin prothrombin JJ cord-010119-t1x9gknd 2960 3 time time NN cord-010119-t1x9gknd 2960 4 ( ( -LRB- cord-010119-t1x9gknd 2960 5 PT PT NNP cord-010119-t1x9gknd 2960 6 ) ) -RRB- cord-010119-t1x9gknd 2960 7 , , , cord-010119-t1x9gknd 2960 8 coagulation coagulation NN cord-010119-t1x9gknd 2960 9 properties property NNS cord-010119-t1x9gknd 2960 10 and and CC cord-010119-t1x9gknd 2960 11 platelet platelet NN cord-010119-t1x9gknd 2960 12 aggregation aggregation NN cord-010119-t1x9gknd 2960 13 ( ( -LRB- cord-010119-t1x9gknd 2960 14 response response NN cord-010119-t1x9gknd 2960 15 to to IN cord-010119-t1x9gknd 2960 16 ADP ADP NNP cord-010119-t1x9gknd 2960 17 , , , cord-010119-t1x9gknd 2960 18 collagen collagen NN cord-010119-t1x9gknd 2960 19 and and CC cord-010119-t1x9gknd 2960 20 PAR4 PAR4 NNP cord-010119-t1x9gknd 2960 21 ) ) -RRB- cord-010119-t1x9gknd 2960 22 were be VBD cord-010119-t1x9gknd 2960 23 measured measure VBN cord-010119-t1x9gknd 2960 24 by by IN cord-010119-t1x9gknd 2960 25 hemostasis hemostasis NN cord-010119-t1x9gknd 2960 26 analyzer analyzer NN cord-010119-t1x9gknd 2960 27 , , , cord-010119-t1x9gknd 2960 28 rotational rotational JJ cord-010119-t1x9gknd 2960 29 thromboelastometry thromboelastometry NN cord-010119-t1x9gknd 2960 30 ( ( -LRB- cord-010119-t1x9gknd 2960 31 ROTEM ROTEM NNP cord-010119-t1x9gknd 2960 32 ) ) -RRB- cord-010119-t1x9gknd 2960 33 and and CC cord-010119-t1x9gknd 2960 34 impedance impedance VB cord-010119-t1x9gknd 2960 35 aggregometry aggregometry NN cord-010119-t1x9gknd 2960 36 ( ( -LRB- cord-010119-t1x9gknd 2960 37 Multiplate Multiplate NNP cord-010119-t1x9gknd 2960 38 ) ) -RRB- cord-010119-t1x9gknd 2960 39 respectively respectively RB cord-010119-t1x9gknd 2960 40 within within IN cord-010119-t1x9gknd 2960 41 30min 30min NN cord-010119-t1x9gknd 2960 42 and and CC cord-010119-t1x9gknd 2960 43 2hr 2hr NN cord-010119-t1x9gknd 2960 44 after after IN cord-010119-t1x9gknd 2960 45 incubation incubation NN cord-010119-t1x9gknd 2960 46 . . . cord-010119-t1x9gknd 2961 1 Results/ Results/ . cord-010119-t1x9gknd 2962 1 Finding finding NN cord-010119-t1x9gknd 2962 2 : : : cord-010119-t1x9gknd 2963 1 Tissue tissue NN cord-010119-t1x9gknd 2963 2 factor factor NN cord-010119-t1x9gknd 2963 3 was be VBD cord-010119-t1x9gknd 2963 4 significantly significantly RB cord-010119-t1x9gknd 2963 5 expressed express VBN cord-010119-t1x9gknd 2963 6 among among IN cord-010119-t1x9gknd 2963 7 both both DT cord-010119-t1x9gknd 2963 8 BMSC BMSC NNP cord-010119-t1x9gknd 2963 9 and and CC cord-010119-t1x9gknd 2963 10 AMSC AMSC NNP cord-010119-t1x9gknd 2963 11 at at IN cord-010119-t1x9gknd 2963 12 all all DT cord-010119-t1x9gknd 2963 13 passages passage NNS cord-010119-t1x9gknd 2963 14 in in IN cord-010119-t1x9gknd 2963 15 vitro vitro FW cord-010119-t1x9gknd 2963 16 . . . cord-010119-t1x9gknd 2964 1 BMSC BMSC NNP cord-010119-t1x9gknd 2964 2 and and CC cord-010119-t1x9gknd 2964 3 AMSC AMSC NNP cord-010119-t1x9gknd 2964 4 at at IN cord-010119-t1x9gknd 2964 5 any any DT cord-010119-t1x9gknd 2964 6 dose dose NN cord-010119-t1x9gknd 2964 7 and and CC cord-010119-t1x9gknd 2964 8 time time NN cord-010119-t1x9gknd 2964 9 of of IN cord-010119-t1x9gknd 2964 10 treatment treatment NN cord-010119-t1x9gknd 2964 11 neither neither CC cord-010119-t1x9gknd 2964 12 shortened shorten VBN cord-010119-t1x9gknd 2964 13 nor nor CC cord-010119-t1x9gknd 2964 14 elongated elongated JJ cord-010119-t1x9gknd 2964 15 PT pt NN cord-010119-t1x9gknd 2964 16 in in IN cord-010119-t1x9gknd 2964 17 whole whole JJ cord-010119-t1x9gknd 2964 18 blood blood NN cord-010119-t1x9gknd 2964 19 . . . cord-010119-t1x9gknd 2965 1 However however RB cord-010119-t1x9gknd 2965 2 , , , cord-010119-t1x9gknd 2965 3 both both CC cord-010119-t1x9gknd 2965 4 BMSC BMSC NNP cord-010119-t1x9gknd 2965 5 and and CC cord-010119-t1x9gknd 2965 6 AMSC AMSC NNP cord-010119-t1x9gknd 2965 7 significantly significantly RB cord-010119-t1x9gknd 2965 8 shortened shorten VBD cord-010119-t1x9gknd 2965 9 the the DT cord-010119-t1x9gknd 2965 10 clotting clotting NN cord-010119-t1x9gknd 2965 11 time time NN cord-010119-t1x9gknd 2965 12 ( ( -LRB- cord-010119-t1x9gknd 2965 13 CT CT NNP cord-010119-t1x9gknd 2965 14 ) ) -RRB- cord-010119-t1x9gknd 2966 1 ( ( -LRB- cord-010119-t1x9gknd 2966 2 None none NN cord-010119-t1x9gknd 2966 3 : : : cord-010119-t1x9gknd 2966 4 334 334 CD cord-010119-t1x9gknd 2966 5 6 6 CD cord-010119-t1x9gknd 2966 6 35 35 CD cord-010119-t1x9gknd 2966 7 seconds second NNS cord-010119-t1x9gknd 2966 8 , , , cord-010119-t1x9gknd 2966 9 versus versus IN cord-010119-t1x9gknd 2966 10 low low JJ cord-010119-t1x9gknd 2966 11 , , , cord-010119-t1x9gknd 2966 12 medium medium JJ cord-010119-t1x9gknd 2966 13 and and CC cord-010119-t1x9gknd 2966 14 high high JJ cord-010119-t1x9gknd 2966 15 doses dose NNS cord-010119-t1x9gknd 2966 16 of of IN cord-010119-t1x9gknd 2966 17 AMSC AMSC NNP cord-010119-t1x9gknd 2966 18 ( ( -LRB- cord-010119-t1x9gknd 2966 19 145 145 CD cord-010119-t1x9gknd 2966 20 6 6 CD cord-010119-t1x9gknd 2966 21 2 2 CD cord-010119-t1x9gknd 2966 22 , , , cord-010119-t1x9gknd 2966 23 111 111 CD cord-010119-t1x9gknd 2966 24 6 6 CD cord-010119-t1x9gknd 2966 25 6 6 CD cord-010119-t1x9gknd 2966 26 , , , cord-010119-t1x9gknd 2966 27 and and CC cord-010119-t1x9gknd 2966 28 75 75 CD cord-010119-t1x9gknd 2966 29 6 6 CD cord-010119-t1x9gknd 2966 30 12 12 CD cord-010119-t1x9gknd 2966 31 seconds second NNS cord-010119-t1x9gknd 2966 32 ) ) -RRB- cord-010119-t1x9gknd 2966 33 , , , cord-010119-t1x9gknd 2966 34 and and CC cord-010119-t1x9gknd 2966 35 BMSC BMSC NNP cord-010119-t1x9gknd 2966 36 ( ( -LRB- cord-010119-t1x9gknd 2966 37 155 155 CD cord-010119-t1x9gknd 2966 38 6 6 CD cord-010119-t1x9gknd 2966 39 2 2 CD cord-010119-t1x9gknd 2966 40 , , , cord-010119-t1x9gknd 2966 41 90 90 CD cord-010119-t1x9gknd 2966 42 6 6 CD cord-010119-t1x9gknd 2966 43 10 10 CD cord-010119-t1x9gknd 2966 44 , , , cord-010119-t1x9gknd 2966 45 80 80 CD cord-010119-t1x9gknd 2966 46 6 6 CD cord-010119-t1x9gknd 2966 47 7.0 7.0 CD cord-010119-t1x9gknd 2966 48 seconds second NNS cord-010119-t1x9gknd 2966 49 ) ) -RRB- cord-010119-t1x9gknd 2966 50 , , , cord-010119-t1x9gknd 2966 51 p<0.05 p<0.05 CD cord-010119-t1x9gknd 2966 52 ) ) -RRB- cord-010119-t1x9gknd 2966 53 , , , cord-010119-t1x9gknd 2966 54 clot clot NN cord-010119-t1x9gknd 2966 55 formation formation NN cord-010119-t1x9gknd 2966 56 time time NN cord-010119-t1x9gknd 2966 57 ( ( -LRB- cord-010119-t1x9gknd 2966 58 CFT CFT NNP cord-010119-t1x9gknd 2966 59 , , , cord-010119-t1x9gknd 2966 60 p<0.05 p<0.05 CD cord-010119-t1x9gknd 2966 61 ) ) -RRB- cord-010119-t1x9gknd 2966 62 and and CC cord-010119-t1x9gknd 2966 63 increased increase VBN cord-010119-t1x9gknd 2966 64 alpha alpha NN cord-010119-t1x9gknd 2966 65 angle angle NN cord-010119-t1x9gknd 2966 66 ( ( -LRB- cord-010119-t1x9gknd 2966 67 p<0.05 p<0.05 CD cord-010119-t1x9gknd 2966 68 ) ) -RRB- cord-010119-t1x9gknd 2966 69 by by IN cord-010119-t1x9gknd 2966 70 NATEM NATEM NNP cord-010119-t1x9gknd 2966 71 measurement measurement NN cord-010119-t1x9gknd 2966 72 , , , cord-010119-t1x9gknd 2966 73 but but CC cord-010119-t1x9gknd 2966 74 did do VBD cord-010119-t1x9gknd 2966 75 not not RB cord-010119-t1x9gknd 2966 76 significantly significantly RB cord-010119-t1x9gknd 2966 77 affect affect VB cord-010119-t1x9gknd 2966 78 the the DT cord-010119-t1x9gknd 2966 79 CT CT NNP cord-010119-t1x9gknd 2966 80 , , , cord-010119-t1x9gknd 2966 81 CFT CFT NNP cord-010119-t1x9gknd 2966 82 and and CC cord-010119-t1x9gknd 2966 83 alpha alpha NN cord-010119-t1x9gknd 2966 84 angle angle NN cord-010119-t1x9gknd 2966 85 by by IN cord-010119-t1x9gknd 2966 86 EXTEM EXTEM NNP cord-010119-t1x9gknd 2966 87 . . . cord-010119-t1x9gknd 2967 1 Maximum maximum JJ cord-010119-t1x9gknd 2967 2 clot clot NN cord-010119-t1x9gknd 2967 3 firmness firmness NN cord-010119-t1x9gknd 2967 4 ( ( -LRB- cord-010119-t1x9gknd 2967 5 MCF MCF NNP cord-010119-t1x9gknd 2967 6 ) ) -RRB- cord-010119-t1x9gknd 2967 7 and and CC cord-010119-t1x9gknd 2967 8 fibrinolytic fibrinolytic JJ cord-010119-t1x9gknd 2967 9 index index NN cord-010119-t1x9gknd 2967 10 were be VBD cord-010119-t1x9gknd 2967 11 not not RB cord-010119-t1x9gknd 2967 12 affected affect VBN cord-010119-t1x9gknd 2967 13 by by IN cord-010119-t1x9gknd 2967 14 MSCs msc NNS cord-010119-t1x9gknd 2967 15 . . . cord-010119-t1x9gknd 2968 1 There there EX cord-010119-t1x9gknd 2968 2 was be VBD cord-010119-t1x9gknd 2968 3 no no DT cord-010119-t1x9gknd 2968 4 significant significant JJ cord-010119-t1x9gknd 2968 5 impact impact NN cord-010119-t1x9gknd 2968 6 of of IN cord-010119-t1x9gknd 2968 7 both both DT cord-010119-t1x9gknd 2968 8 BMSC BMSC NNP cord-010119-t1x9gknd 2968 9 and and CC cord-010119-t1x9gknd 2968 10 AMSC AMSC NNP cord-010119-t1x9gknd 2968 11 on on IN cord-010119-t1x9gknd 2968 12 platelet platelet NN cord-010119-t1x9gknd 2968 13 aggregation aggregation NN cord-010119-t1x9gknd 2968 14 simulated simulate VBN cord-010119-t1x9gknd 2968 15 by by IN cord-010119-t1x9gknd 2968 16 ADP ADP NNP cord-010119-t1x9gknd 2968 17 , , , cord-010119-t1x9gknd 2968 18 collagen collagen NN cord-010119-t1x9gknd 2968 19 and and CC cord-010119-t1x9gknd 2968 20 PAR4 PAR4 NNP cord-010119-t1x9gknd 2968 21 . . . cord-010119-t1x9gknd 2969 1 No no DT cord-010119-t1x9gknd 2969 2 significant significant JJ cord-010119-t1x9gknd 2969 3 differences difference NNS cord-010119-t1x9gknd 2969 4 of of IN cord-010119-t1x9gknd 2969 5 hemostatic hemostatic JJ cord-010119-t1x9gknd 2969 6 and and CC cord-010119-t1x9gknd 2969 7 platelet platelet NN cord-010119-t1x9gknd 2969 8 function function NN cord-010119-t1x9gknd 2969 9 were be VBD cord-010119-t1x9gknd 2969 10 found find VBN cord-010119-t1x9gknd 2969 11 between between IN cord-010119-t1x9gknd 2969 12 the the DT cord-010119-t1x9gknd 2969 13 treatments treatment NNS cord-010119-t1x9gknd 2969 14 of of IN cord-010119-t1x9gknd 2969 15 BMSC BMSC NNP cord-010119-t1x9gknd 2969 16 and and CC cord-010119-t1x9gknd 2969 17 AMSC AMSC NNP cord-010119-t1x9gknd 2969 18 . . . cord-010119-t1x9gknd 2970 1 Conclusion conclusion NN cord-010119-t1x9gknd 2970 2 : : : cord-010119-t1x9gknd 2971 1 Consistent consistent JJ cord-010119-t1x9gknd 2971 2 with with IN cord-010119-t1x9gknd 2971 3 reports report NNS cord-010119-t1x9gknd 2971 4 from from IN cord-010119-t1x9gknd 2971 5 human human JJ cord-010119-t1x9gknd 2971 6 derived derive VBN cord-010119-t1x9gknd 2971 7 MSC MSC NNP cord-010119-t1x9gknd 2971 8 , , , cord-010119-t1x9gknd 2971 9 both both DT cord-010119-t1x9gknd 2971 10 rat rat NN cord-010119-t1x9gknd 2971 11 BMSC BMSC NNP cord-010119-t1x9gknd 2971 12 and and CC cord-010119-t1x9gknd 2971 13 AMSC AMSC NNP cord-010119-t1x9gknd 2971 14 significantly significantly RB cord-010119-t1x9gknd 2971 15 expressed express VBD cord-010119-t1x9gknd 2971 16 tissue tissue NN cord-010119-t1x9gknd 2971 17 factor factor NN cord-010119-t1x9gknd 2971 18 in in IN cord-010119-t1x9gknd 2971 19 both both CC cord-010119-t1x9gknd 2971 20 early early JJ cord-010119-t1x9gknd 2971 21 and and CC cord-010119-t1x9gknd 2971 22 late late JJ cord-010119-t1x9gknd 2971 23 passages passage NNS cord-010119-t1x9gknd 2971 24 , , , cord-010119-t1x9gknd 2971 25 which which WDT cord-010119-t1x9gknd 2971 26 led lead VBD cord-010119-t1x9gknd 2971 27 to to IN cord-010119-t1x9gknd 2971 28 a a DT cord-010119-t1x9gknd 2971 29 significant significant JJ cord-010119-t1x9gknd 2971 30 decrease decrease NN cord-010119-t1x9gknd 2971 31 in in IN cord-010119-t1x9gknd 2971 32 clotting clotting NN cord-010119-t1x9gknd 2971 33 time time NN cord-010119-t1x9gknd 2971 34 at at IN cord-010119-t1x9gknd 2971 35 various various JJ cord-010119-t1x9gknd 2971 36 dose dose NN cord-010119-t1x9gknd 2971 37 and and CC cord-010119-t1x9gknd 2971 38 time time NN cord-010119-t1x9gknd 2971 39 of of IN cord-010119-t1x9gknd 2971 40 treatment treatment NN cord-010119-t1x9gknd 2971 41 . . . cord-010119-t1x9gknd 2972 1 However however RB cord-010119-t1x9gknd 2972 2 , , , cord-010119-t1x9gknd 2972 3 MSCs msc NNS cord-010119-t1x9gknd 2972 4 had have VBD cord-010119-t1x9gknd 2972 5 no no DT cord-010119-t1x9gknd 2972 6 direct direct JJ cord-010119-t1x9gknd 2972 7 impact impact NN cord-010119-t1x9gknd 2972 8 on on IN cord-010119-t1x9gknd 2972 9 platelet platelet NN cord-010119-t1x9gknd 2972 10 aggregation aggregation NN cord-010119-t1x9gknd 2972 11 in in IN cord-010119-t1x9gknd 2972 12 vitro vitro FW cord-010119-t1x9gknd 2972 13 . . . cord-010119-t1x9gknd 2973 1 As as IN cord-010119-t1x9gknd 2973 2 considering consider VBG cord-010119-t1x9gknd 2973 3 the the DT cord-010119-t1x9gknd 2973 4 procoagulant procoagulant JJ cord-010119-t1x9gknd 2973 5 capability capability NN cord-010119-t1x9gknd 2973 6 of of IN cord-010119-t1x9gknd 2973 7 MSCs msc NNS cord-010119-t1x9gknd 2973 8 , , , cord-010119-t1x9gknd 2973 9 future future JJ cord-010119-t1x9gknd 2973 10 study study NN cord-010119-t1x9gknd 2973 11 will will MD cord-010119-t1x9gknd 2973 12 be be VB cord-010119-t1x9gknd 2973 13 necessary necessary JJ cord-010119-t1x9gknd 2973 14 to to TO cord-010119-t1x9gknd 2973 15 determine determine VB cord-010119-t1x9gknd 2973 16 the the DT cord-010119-t1x9gknd 2973 17 optimal optimal JJ cord-010119-t1x9gknd 2973 18 dose dose NN cord-010119-t1x9gknd 2973 19 and and CC cord-010119-t1x9gknd 2973 20 safety safety NN cord-010119-t1x9gknd 2973 21 of of IN cord-010119-t1x9gknd 2973 22 using use VBG cord-010119-t1x9gknd 2973 23 MSCs msc NNS cord-010119-t1x9gknd 2973 24 for for IN cord-010119-t1x9gknd 2973 25 systemic systemic JJ cord-010119-t1x9gknd 2973 26 application application NN cord-010119-t1x9gknd 2973 27 in in IN cord-010119-t1x9gknd 2973 28 vivo vivo NNP cord-010119-t1x9gknd 2973 29 . . . cord-010119-t1x9gknd 2974 1 Comparison comparison NN cord-010119-t1x9gknd 2974 2 of of IN cord-010119-t1x9gknd 2974 3 the the DT cord-010119-t1x9gknd 2974 4 Terumo Terumo NNP cord-010119-t1x9gknd 2974 5 BCT BCT NNP cord-010119-t1x9gknd 2974 6 MNC MNC NNP cord-010119-t1x9gknd 2974 7 and and CC cord-010119-t1x9gknd 2974 8 Cmnc Cmnc NNP cord-010119-t1x9gknd 2974 9 Protocols Protocols NNPS cord-010119-t1x9gknd 2974 10 for for IN cord-010119-t1x9gknd 2974 11 Peripheral Peripheral NNP cord-010119-t1x9gknd 2974 12 Blood Blood NNP cord-010119-t1x9gknd 2974 13 Stem Stem NNP cord-010119-t1x9gknd 2974 14 Cell cell NN cord-010119-t1x9gknd 2974 15 Collections collection NNS cord-010119-t1x9gknd 2974 16 Lindsey Lindsey NNP cord-010119-t1x9gknd 2974 17 Westbrook Westbrook NNP cord-010119-t1x9gknd 2974 18 * * NFP cord-010119-t1x9gknd 2974 19 1 1 CD cord-010119-t1x9gknd 2974 20 , , , cord-010119-t1x9gknd 2974 21 Neil Neil NNP cord-010119-t1x9gknd 2974 22 Bagamasbad Bagamasbad NNP cord-010119-t1x9gknd 2974 23 2 2 CD cord-010119-t1x9gknd 2974 24 , , , cord-010119-t1x9gknd 2974 25 Reynold Reynold NNP cord-010119-t1x9gknd 2974 26 Dilag Dilag NNP cord-010119-t1x9gknd 2974 27 2 2 CD cord-010119-t1x9gknd 2974 28 , , , cord-010119-t1x9gknd 2974 29 Melissa Melissa NNP cord-010119-t1x9gknd 2974 30 Nasser Nasser NNP cord-010119-t1x9gknd 2974 31 2 2 CD cord-010119-t1x9gknd 2974 32 , , , cord-010119-t1x9gknd 2974 33 Nicole Nicole NNP cord-010119-t1x9gknd 2974 34 Bauer Bauer NNP cord-010119-t1x9gknd 2974 35 2 2 CD cord-010119-t1x9gknd 2974 36 , , , cord-010119-t1x9gknd 2974 37 Jennifer Jennifer NNP cord-010119-t1x9gknd 2974 38 Wheeler Wheeler NNP cord-010119-t1x9gknd 2974 39 3 3 CD cord-010119-t1x9gknd 2974 40 and and CC cord-010119-t1x9gknd 2974 41 Mary Mary NNP cord-010119-t1x9gknd 2974 42 Berg Berg NNP cord-010119-t1x9gknd 2975 1 1 1 LS cord-010119-t1x9gknd 2975 2 . . . cord-010119-t1x9gknd 2976 1 1 1 LS cord-010119-t1x9gknd 2976 2 Department Department NNP cord-010119-t1x9gknd 2976 3 of of IN cord-010119-t1x9gknd 2976 4 Pathology Pathology NNP cord-010119-t1x9gknd 2976 5 , , , cord-010119-t1x9gknd 2976 6 University University NNP cord-010119-t1x9gknd 2976 7 of of IN cord-010119-t1x9gknd 2976 8 Colorado Colorado NNP cord-010119-t1x9gknd 2976 9 -Anschutz -Anschutz : cord-010119-t1x9gknd 2976 10 Medical Medical NNP cord-010119-t1x9gknd 2976 11 Campus Campus NNP cord-010119-t1x9gknd 2976 12 , , , cord-010119-t1x9gknd 2976 13 2 2 CD cord-010119-t1x9gknd 2976 14 Department Department NNP cord-010119-t1x9gknd 2976 15 of of IN cord-010119-t1x9gknd 2976 16 Medicine Medicine NNP cord-010119-t1x9gknd 2976 17 , , , cord-010119-t1x9gknd 2976 18 Division Division NNP cord-010119-t1x9gknd 2976 19 of of IN cord-010119-t1x9gknd 2976 20 Hematology Hematology NNP cord-010119-t1x9gknd 2976 21 , , , cord-010119-t1x9gknd 2976 22 University University NNP cord-010119-t1x9gknd 2976 23 of of IN cord-010119-t1x9gknd 2976 24 Colorado Colorado NNP cord-010119-t1x9gknd 2976 25 Hospital Hospital NNP cord-010119-t1x9gknd 2976 26 , , , cord-010119-t1x9gknd 2976 27 3 3 CD cord-010119-t1x9gknd 2976 28 Scientific Scientific NNP cord-010119-t1x9gknd 2976 29 Support Support NNP cord-010119-t1x9gknd 2976 30 , , , cord-010119-t1x9gknd 2976 31 Terumo Terumo NNP cord-010119-t1x9gknd 2976 32 BCT BCT NNP cord-010119-t1x9gknd 2976 33 Background Background NNP cord-010119-t1x9gknd 2976 34 / / SYM cord-010119-t1x9gknd 2976 35 Case Case NNP cord-010119-t1x9gknd 2976 36 Studies Studies NNPS cord-010119-t1x9gknd 2976 37 : : : cord-010119-t1x9gknd 2976 38 Terumo Terumo NNP cord-010119-t1x9gknd 2976 39 BCT BCT NNP cord-010119-t1x9gknd 2976 40 recently recently RB cord-010119-t1x9gknd 2976 41 offered offer VBD cord-010119-t1x9gknd 2976 42 a a DT cord-010119-t1x9gknd 2976 43 new new JJ cord-010119-t1x9gknd 2976 44 method method NN cord-010119-t1x9gknd 2976 45 of of IN cord-010119-t1x9gknd 2976 46 peripheral peripheral JJ cord-010119-t1x9gknd 2976 47 blood blood NN cord-010119-t1x9gknd 2976 48 stem stem NN cord-010119-t1x9gknd 2976 49 cell cell NN cord-010119-t1x9gknd 2976 50 ( ( -LRB- cord-010119-t1x9gknd 2976 51 PBSC PBSC NNP cord-010119-t1x9gknd 2976 52 ) ) -RRB- cord-010119-t1x9gknd 2976 53 collection collection NN cord-010119-t1x9gknd 2976 54 using use VBG cord-010119-t1x9gknd 2976 55 the the DT cord-010119-t1x9gknd 2976 56 Spectra Spectra NNP cord-010119-t1x9gknd 2976 57 Optia Optia NNP cord-010119-t1x9gknd 2976 58 , , , cord-010119-t1x9gknd 2976 59 an an DT cord-010119-t1x9gknd 2976 60 apheresis apheresis NN cord-010119-t1x9gknd 2976 61 instrument instrument NN cord-010119-t1x9gknd 2976 62 . . . cord-010119-t1x9gknd 2977 1 The the DT cord-010119-t1x9gknd 2977 2 new new JJ cord-010119-t1x9gknd 2977 3 protocol protocol NN cord-010119-t1x9gknd 2977 4 , , , cord-010119-t1x9gknd 2977 5 Continuous continuous JJ cord-010119-t1x9gknd 2977 6 mononuclear mononuclear JJ cord-010119-t1x9gknd 2977 7 cell cell NN cord-010119-t1x9gknd 2977 8 collection collection NN cord-010119-t1x9gknd 2977 9 ( ( -LRB- cord-010119-t1x9gknd 2977 10 CMNC CMNC NNP cord-010119-t1x9gknd 2977 11 ) ) -RRB- cord-010119-t1x9gknd 2977 12 collects collect VBZ cord-010119-t1x9gknd 2977 13 cells cell NNS cord-010119-t1x9gknd 2977 14 continuously continuously RB cord-010119-t1x9gknd 2977 15 as as IN cord-010119-t1x9gknd 2977 16 opposed oppose VBN cord-010119-t1x9gknd 2977 17 to to IN cord-010119-t1x9gknd 2977 18 the the DT cord-010119-t1x9gknd 2977 19 older old JJR cord-010119-t1x9gknd 2977 20 protocol protocol NN cord-010119-t1x9gknd 2977 21 , , , cord-010119-t1x9gknd 2977 22 the the DT cord-010119-t1x9gknd 2977 23 Mononuclear Mononuclear NNP cord-010119-t1x9gknd 2977 24 cell cell NN cord-010119-t1x9gknd 2977 25 collection collection NN cord-010119-t1x9gknd 2977 26 ( ( -LRB- cord-010119-t1x9gknd 2977 27 MNC MNC NNP cord-010119-t1x9gknd 2977 28 ) ) -RRB- cord-010119-t1x9gknd 2977 29 protocol protocol NN cord-010119-t1x9gknd 2977 30 , , , cord-010119-t1x9gknd 2977 31 which which WDT cord-010119-t1x9gknd 2977 32 is be VBZ cord-010119-t1x9gknd 2977 33 batch batch NN cord-010119-t1x9gknd 2977 34 collection collection NN cord-010119-t1x9gknd 2977 35 or or CC cord-010119-t1x9gknd 2977 36 dual dual JJ cord-010119-t1x9gknd 2977 37 stage stage NN cord-010119-t1x9gknd 2977 38 collection collection NN cord-010119-t1x9gknd 2977 39 , , , cord-010119-t1x9gknd 2977 40 involving involve VBG cord-010119-t1x9gknd 2977 41 an an DT cord-010119-t1x9gknd 2977 42 additional additional JJ cord-010119-t1x9gknd 2977 43 step step NN cord-010119-t1x9gknd 2977 44 where where WRB cord-010119-t1x9gknd 2977 45 platelets platelet NNS cord-010119-t1x9gknd 2977 46 are be VBP cord-010119-t1x9gknd 2977 47 separated separate VBN cord-010119-t1x9gknd 2977 48 from from IN cord-010119-t1x9gknd 2977 49 MNC MNC NNP cord-010119-t1x9gknd 2977 50 within within IN cord-010119-t1x9gknd 2977 51 a a DT cord-010119-t1x9gknd 2977 52 cell cell NN cord-010119-t1x9gknd 2977 53 separation separation NN cord-010119-t1x9gknd 2977 54 chamber chamber NN cord-010119-t1x9gknd 2977 55 . . . cord-010119-t1x9gknd 2978 1 Our -PRON- PRP$ cord-010119-t1x9gknd 2978 2 institution institution NN cord-010119-t1x9gknd 2978 3 has have VBZ cord-010119-t1x9gknd 2978 4 used use VBN cord-010119-t1x9gknd 2978 5 both both DT cord-010119-t1x9gknd 2978 6 protocols protocol NNS cord-010119-t1x9gknd 2978 7 and and CC cord-010119-t1x9gknd 2978 8 the the DT cord-010119-t1x9gknd 2978 9 purpose purpose NN cord-010119-t1x9gknd 2978 10 of of IN cord-010119-t1x9gknd 2978 11 this this DT cord-010119-t1x9gknd 2978 12 study study NN cord-010119-t1x9gknd 2978 13 was be VBD cord-010119-t1x9gknd 2978 14 to to TO cord-010119-t1x9gknd 2978 15 compare compare VB cord-010119-t1x9gknd 2978 16 PBSC PBSC NNP cord-010119-t1x9gknd 2978 17 product product NN cord-010119-t1x9gknd 2978 18 characteristics characteristic NNS cord-010119-t1x9gknd 2978 19 and and CC cord-010119-t1x9gknd 2978 20 run run VB cord-010119-t1x9gknd 2978 21 times time NNS cord-010119-t1x9gknd 2978 22 between between IN cord-010119-t1x9gknd 2978 23 the the DT cord-010119-t1x9gknd 2978 24 CMNC CMNC NNP cord-010119-t1x9gknd 2978 25 and and CC cord-010119-t1x9gknd 2978 26 the the DT cord-010119-t1x9gknd 2978 27 MNC MNC NNP cord-010119-t1x9gknd 2978 28 protocols protocol NNS cord-010119-t1x9gknd 2978 29 . . . cord-010119-t1x9gknd 2979 1 Study Study NNP cord-010119-t1x9gknd 2979 2 Design Design NNP cord-010119-t1x9gknd 2979 3 / / SYM cord-010119-t1x9gknd 2979 4 Method method NN cord-010119-t1x9gknd 2979 5 : : : cord-010119-t1x9gknd 2980 1 A a DT cord-010119-t1x9gknd 2980 2 retrospective retrospective JJ cord-010119-t1x9gknd 2980 3 review review NN cord-010119-t1x9gknd 2980 4 and and CC cord-010119-t1x9gknd 2980 5 comparison comparison NN cord-010119-t1x9gknd 2980 6 of of IN cord-010119-t1x9gknd 2980 7 parameters parameter NNS cord-010119-t1x9gknd 2980 8 from from IN cord-010119-t1x9gknd 2980 9 120 120 CD cord-010119-t1x9gknd 2980 10 collection collection NN cord-010119-t1x9gknd 2980 11 procedures procedure NNS cord-010119-t1x9gknd 2980 12 using use VBG cord-010119-t1x9gknd 2980 13 the the DT cord-010119-t1x9gknd 2980 14 MNC MNC NNP cord-010119-t1x9gknd 2980 15 protocol protocol NN cord-010119-t1x9gknd 2980 16 and and CC cord-010119-t1x9gknd 2980 17 173 173 CD cord-010119-t1x9gknd 2980 18 collection collection NN cord-010119-t1x9gknd 2980 19 procedures procedure NNS cord-010119-t1x9gknd 2980 20 using use VBG cord-010119-t1x9gknd 2980 21 the the DT cord-010119-t1x9gknd 2980 22 CMNC CMNC NNP cord-010119-t1x9gknd 2980 23 protocol protocol NN cord-010119-t1x9gknd 2980 24 was be VBD cord-010119-t1x9gknd 2980 25 done do VBN cord-010119-t1x9gknd 2980 26 using use VBG cord-010119-t1x9gknd 2980 27 the the DT cord-010119-t1x9gknd 2980 28 t t NN cord-010119-t1x9gknd 2980 29 - - HYPH cord-010119-t1x9gknd 2980 30 test test NN cord-010119-t1x9gknd 2980 31 . . . cord-010119-t1x9gknd 2981 1 Data datum NNS cord-010119-t1x9gknd 2981 2 from from IN cord-010119-t1x9gknd 2981 3 patients patient NNS cord-010119-t1x9gknd 2981 4 / / SYM cord-010119-t1x9gknd 2981 5 donors donor NNS cord-010119-t1x9gknd 2981 6 ( ( -LRB- cord-010119-t1x9gknd 2981 7 including include VBG cord-010119-t1x9gknd 2981 8 36 36 CD cord-010119-t1x9gknd 2981 9 allogeneic allogeneic IN cord-010119-t1x9gknd 2981 10 donors donor NNS cord-010119-t1x9gknd 2981 11 ) ) -RRB- cord-010119-t1x9gknd 2981 12 as as RB cord-010119-t1x9gknd 2981 13 well well RB cord-010119-t1x9gknd 2981 14 as as IN cord-010119-t1x9gknd 2981 15 procedure procedure NN cord-010119-t1x9gknd 2981 16 details detail NNS cord-010119-t1x9gknd 2981 17 including include VBG cord-010119-t1x9gknd 2981 18 run run VBN cord-010119-t1x9gknd 2981 19 time time NN cord-010119-t1x9gknd 2981 20 , , , cord-010119-t1x9gknd 2981 21 flow flow NN cord-010119-t1x9gknd 2981 22 cytometry cytometry NN cord-010119-t1x9gknd 2981 23 marker marker NN cord-010119-t1x9gknd 2981 24 for for IN cord-010119-t1x9gknd 2981 25 stem stem NN cord-010119-t1x9gknd 2981 26 cells cell NNS cord-010119-t1x9gknd 2981 27 ( ( -LRB- cord-010119-t1x9gknd 2981 28 CD34)-positive CD34)-positive NNP cord-010119-t1x9gknd 2981 29 ( ( -LRB- cord-010119-t1x9gknd 2981 30 CD341 cd341 NN cord-010119-t1x9gknd 2981 31 ) ) -RRB- cord-010119-t1x9gknd 2981 32 throughput throughput NN cord-010119-t1x9gknd 2981 33 , , , cord-010119-t1x9gknd 2981 34 CD341 cd341 NN cord-010119-t1x9gknd 2981 35 collection collection NN cord-010119-t1x9gknd 2981 36 efficiency efficiency NN cord-010119-t1x9gknd 2981 37 ( ( -LRB- cord-010119-t1x9gknd 2981 38 CE% CE% NNP cord-010119-t1x9gknd 2981 39 ) ) -RRB- cord-010119-t1x9gknd 2981 40 , , , cord-010119-t1x9gknd 2981 41 platelet platelet NN cord-010119-t1x9gknd 2981 42 loss loss NN cord-010119-t1x9gknd 2981 43 71A 71a CD cord-010119-t1x9gknd 2981 44 TRANSFUSION transfusion NN cord-010119-t1x9gknd 2981 45 per per IN cord-010119-t1x9gknd 2981 46 total total JJ cord-010119-t1x9gknd 2981 47 blood blood NN cord-010119-t1x9gknd 2981 48 volume volume NN cord-010119-t1x9gknd 2981 49 processed process VBN cord-010119-t1x9gknd 2981 50 ( ( -LRB- cord-010119-t1x9gknd 2981 51 plt plt NNP cord-010119-t1x9gknd 2981 52 loss loss NNP cord-010119-t1x9gknd 2981 53 / / SYM cord-010119-t1x9gknd 2981 54 TBV TBV NNP cord-010119-t1x9gknd 2981 55 ) ) -RRB- cord-010119-t1x9gknd 2981 56 , , , cord-010119-t1x9gknd 2981 57 and and CC cord-010119-t1x9gknd 2981 58 collection collection NN cord-010119-t1x9gknd 2981 59 product product NN cord-010119-t1x9gknd 2981 60 characteristics characteristic NNS cord-010119-t1x9gknd 2981 61 were be VBD cord-010119-t1x9gknd 2981 62 included include VBN cord-010119-t1x9gknd 2981 63 in in IN cord-010119-t1x9gknd 2981 64 the the DT cord-010119-t1x9gknd 2981 65 analysis analysis NN cord-010119-t1x9gknd 2981 66 . . . cord-010119-t1x9gknd 2982 1 Results/ Results/ . cord-010119-t1x9gknd 2983 1 Finding finding NN cord-010119-t1x9gknd 2983 2 : : : cord-010119-t1x9gknd 2984 1 Numerical numerical JJ cord-010119-t1x9gknd 2984 2 results result NNS cord-010119-t1x9gknd 2984 3 are be VBP cord-010119-t1x9gknd 2984 4 summarized summarize VBN cord-010119-t1x9gknd 2984 5 in in IN cord-010119-t1x9gknd 2984 6 the the DT cord-010119-t1x9gknd 2984 7 Table table NN cord-010119-t1x9gknd 2984 8 . . . cord-010119-t1x9gknd 2985 1 The the DT cord-010119-t1x9gknd 2985 2 MNC MNC NNP cord-010119-t1x9gknd 2985 3 and and CC cord-010119-t1x9gknd 2985 4 CMNC CMNC NNP cord-010119-t1x9gknd 2985 5 donor donor NN cord-010119-t1x9gknd 2985 6 groups group NNS cord-010119-t1x9gknd 2985 7 included include VBD cord-010119-t1x9gknd 2985 8 14 14 CD cord-010119-t1x9gknd 2985 9 and and CC cord-010119-t1x9gknd 2985 10 22 22 CD cord-010119-t1x9gknd 2985 11 allogeneic allogeneic NN cord-010119-t1x9gknd 2985 12 donors donor NNS cord-010119-t1x9gknd 2985 13 , , , cord-010119-t1x9gknd 2985 14 respectively respectively RB cord-010119-t1x9gknd 2985 15 . . . cord-010119-t1x9gknd 2986 1 Donor donor NN cord-010119-t1x9gknd 2986 2 weight weight NN cord-010119-t1x9gknd 2986 3 was be VBD cord-010119-t1x9gknd 2986 4 not not RB cord-010119-t1x9gknd 2986 5 significantly significantly RB cord-010119-t1x9gknd 2986 6 different different JJ cord-010119-t1x9gknd 2986 7 between between IN cord-010119-t1x9gknd 2986 8 the the DT cord-010119-t1x9gknd 2986 9 two two CD cord-010119-t1x9gknd 2986 10 groups group NNS cord-010119-t1x9gknd 2986 11 . . . cord-010119-t1x9gknd 2987 1 Pre pre JJ cord-010119-t1x9gknd 2987 2 - - JJ cord-010119-t1x9gknd 2987 3 procedure procedure JJ cord-010119-t1x9gknd 2987 4 WBC WBC NNP cord-010119-t1x9gknd 2987 5 values value NNS cord-010119-t1x9gknd 2987 6 were be VBD cord-010119-t1x9gknd 2987 7 also also RB cord-010119-t1x9gknd 2987 8 similar similar JJ cord-010119-t1x9gknd 2987 9 between between IN cord-010119-t1x9gknd 2987 10 the the DT cord-010119-t1x9gknd 2987 11 two two CD cord-010119-t1x9gknd 2987 12 groups group NNS cord-010119-t1x9gknd 2987 13 . . . cord-010119-t1x9gknd 2988 1 Run Run NNP cord-010119-t1x9gknd 2988 2 time time NN cord-010119-t1x9gknd 2988 3 was be VBD cord-010119-t1x9gknd 2988 4 found find VBN cord-010119-t1x9gknd 2988 5 to to TO cord-010119-t1x9gknd 2988 6 be be VB cord-010119-t1x9gknd 2988 7 significantly significantly RB cord-010119-t1x9gknd 2988 8 shorter short JJR cord-010119-t1x9gknd 2988 9 using use VBG cord-010119-t1x9gknd 2988 10 the the DT cord-010119-t1x9gknd 2988 11 CMNC CMNC NNP cord-010119-t1x9gknd 2988 12 protocol protocol NN cord-010119-t1x9gknd 2988 13 compared compare VBN cord-010119-t1x9gknd 2988 14 to to IN cord-010119-t1x9gknd 2988 15 the the DT cord-010119-t1x9gknd 2988 16 MNC MNC NNP cord-010119-t1x9gknd 2988 17 protocol protocol NN cord-010119-t1x9gknd 2988 18 . . . cord-010119-t1x9gknd 2989 1 Product product NN cord-010119-t1x9gknd 2989 2 volume volume NN cord-010119-t1x9gknd 2989 3 was be VBD cord-010119-t1x9gknd 2989 4 also also RB cord-010119-t1x9gknd 2989 5 significantly significantly RB cord-010119-t1x9gknd 2989 6 lower low JJR cord-010119-t1x9gknd 2989 7 in in IN cord-010119-t1x9gknd 2989 8 the the DT cord-010119-t1x9gknd 2989 9 CMNC CMNC NNP cord-010119-t1x9gknd 2989 10 group group NN cord-010119-t1x9gknd 2989 11 compared compare VBN cord-010119-t1x9gknd 2989 12 to to IN cord-010119-t1x9gknd 2989 13 the the DT cord-010119-t1x9gknd 2989 14 MNC MNC NNP cord-010119-t1x9gknd 2989 15 group group NN cord-010119-t1x9gknd 2989 16 . . . cord-010119-t1x9gknd 2990 1 Although although IN cord-010119-t1x9gknd 2990 2 the the DT cord-010119-t1x9gknd 2990 3 volume volume NN cord-010119-t1x9gknd 2990 4 was be VBD cord-010119-t1x9gknd 2990 5 lower low JJR cord-010119-t1x9gknd 2990 6 , , , cord-010119-t1x9gknd 2990 7 the the DT cord-010119-t1x9gknd 2990 8 CMNC CMNC NNP cord-010119-t1x9gknd 2990 9 product product NN cord-010119-t1x9gknd 2990 10 had have VBD cord-010119-t1x9gknd 2990 11 significantly significantly RB cord-010119-t1x9gknd 2990 12 higher high JJR cord-010119-t1x9gknd 2990 13 percentages percentage NNS cord-010119-t1x9gknd 2990 14 of of IN cord-010119-t1x9gknd 2990 15 mononuclear mononuclear JJ cord-010119-t1x9gknd 2990 16 cells cell NNS cord-010119-t1x9gknd 2990 17 ( ( -LRB- cord-010119-t1x9gknd 2990 18 mono% mono% NNP cord-010119-t1x9gknd 2990 19 ) ) -RRB- cord-010119-t1x9gknd 2990 20 and and CC cord-010119-t1x9gknd 2990 21 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 2990 22 ( ( -LRB- cord-010119-t1x9gknd 2990 23 lymph% lymph% NNP cord-010119-t1x9gknd 2990 24 ) ) -RRB- cord-010119-t1x9gknd 2990 25 collected collect VBD cord-010119-t1x9gknd 2990 26 when when WRB cord-010119-t1x9gknd 2990 27 compared compare VBN cord-010119-t1x9gknd 2990 28 to to IN cord-010119-t1x9gknd 2990 29 the the DT cord-010119-t1x9gknd 2990 30 MNC MNC NNP cord-010119-t1x9gknd 2990 31 product product NN cord-010119-t1x9gknd 2990 32 . . . cord-010119-t1x9gknd 2991 1 The the DT cord-010119-t1x9gknd 2991 2 CD341 cd341 NN cord-010119-t1x9gknd 2991 3 throughput throughput NN cord-010119-t1x9gknd 2991 4 was be VBD cord-010119-t1x9gknd 2991 5 significantly significantly RB cord-010119-t1x9gknd 2991 6 higher high JJR cord-010119-t1x9gknd 2991 7 in in IN cord-010119-t1x9gknd 2991 8 the the DT cord-010119-t1x9gknd 2991 9 CMNC CMNC NNP cord-010119-t1x9gknd 2991 10 group group NN cord-010119-t1x9gknd 2991 11 than than IN cord-010119-t1x9gknd 2991 12 the the DT cord-010119-t1x9gknd 2991 13 MNC MNC NNP cord-010119-t1x9gknd 2991 14 group group NN cord-010119-t1x9gknd 2991 15 . . . cord-010119-t1x9gknd 2992 1 The the DT cord-010119-t1x9gknd 2992 2 CD341 cd341 NN cord-010119-t1x9gknd 2992 3 CE% CE% NNP cord-010119-t1x9gknd 2992 4 was be VBD cord-010119-t1x9gknd 2992 5 found find VBN cord-010119-t1x9gknd 2992 6 to to TO cord-010119-t1x9gknd 2992 7 be be VB cord-010119-t1x9gknd 2992 8 slightly slightly RB cord-010119-t1x9gknd 2992 9 increased increase VBN cord-010119-t1x9gknd 2992 10 in in IN cord-010119-t1x9gknd 2992 11 the the DT cord-010119-t1x9gknd 2992 12 CMNC CMNC NNP cord-010119-t1x9gknd 2992 13 group group NN cord-010119-t1x9gknd 2992 14 , , , cord-010119-t1x9gknd 2992 15 though though IN cord-010119-t1x9gknd 2992 16 not not RB cord-010119-t1x9gknd 2992 17 significantly significantly RB cord-010119-t1x9gknd 2992 18 . . . cord-010119-t1x9gknd 2993 1 The the DT cord-010119-t1x9gknd 2993 2 platelet platelet NN cord-010119-t1x9gknd 2993 3 loss loss NN cord-010119-t1x9gknd 2993 4 was be VBD cord-010119-t1x9gknd 2993 5 not not RB cord-010119-t1x9gknd 2993 6 significantly significantly RB cord-010119-t1x9gknd 2993 7 different different JJ cord-010119-t1x9gknd 2993 8 between between IN cord-010119-t1x9gknd 2993 9 the the DT cord-010119-t1x9gknd 2993 10 protocols protocol NNS cord-010119-t1x9gknd 2993 11 when when WRB cord-010119-t1x9gknd 2993 12 normalized normalize VBN cord-010119-t1x9gknd 2993 13 for for IN cord-010119-t1x9gknd 2993 14 total total JJ cord-010119-t1x9gknd 2993 15 blood blood NN cord-010119-t1x9gknd 2993 16 volume volume NN cord-010119-t1x9gknd 2993 17 . . . cord-010119-t1x9gknd 2994 1 Product product NN cord-010119-t1x9gknd 2994 2 hematocrit hematocrit NN cord-010119-t1x9gknd 2994 3 ( ( -LRB- cord-010119-t1x9gknd 2994 4 HCT% hct% NN cord-010119-t1x9gknd 2994 5 ) ) -RRB- cord-010119-t1x9gknd 2994 6 was be VBD cord-010119-t1x9gknd 2994 7 significantly significantly RB cord-010119-t1x9gknd 2994 8 higher high JJR cord-010119-t1x9gknd 2994 9 using use VBG cord-010119-t1x9gknd 2994 10 the the DT cord-010119-t1x9gknd 2994 11 CMNC CMNC NNP cord-010119-t1x9gknd 2994 12 protocol protocol NN cord-010119-t1x9gknd 2994 13 ; ; : cord-010119-t1x9gknd 2994 14 however however RB cord-010119-t1x9gknd 2994 15 , , , cord-010119-t1x9gknd 2994 16 the the DT cord-010119-t1x9gknd 2994 17 red red JJ cord-010119-t1x9gknd 2994 18 blood blood NN cord-010119-t1x9gknd 2994 19 cell cell NN cord-010119-t1x9gknd 2994 20 volume volume NN cord-010119-t1x9gknd 2994 21 never never RB cord-010119-t1x9gknd 2994 22 exceeded exceed VBD cord-010119-t1x9gknd 2994 23 20 20 CD cord-010119-t1x9gknd 2994 24 mL ml NN cord-010119-t1x9gknd 2994 25 due due IN cord-010119-t1x9gknd 2994 26 to to IN cord-010119-t1x9gknd 2994 27 the the DT cord-010119-t1x9gknd 2994 28 lower low JJR cord-010119-t1x9gknd 2994 29 product product NN cord-010119-t1x9gknd 2994 30 volume volume NN cord-010119-t1x9gknd 2994 31 with with IN cord-010119-t1x9gknd 2994 32 the the DT cord-010119-t1x9gknd 2994 33 CMNC CMNC NNP cord-010119-t1x9gknd 2994 34 protocol protocol NN cord-010119-t1x9gknd 2994 35 . . . cord-010119-t1x9gknd 2995 1 The the DT cord-010119-t1x9gknd 2995 2 CMNC CMNC NNP cord-010119-t1x9gknd 2995 3 protocol protocol NN cord-010119-t1x9gknd 2995 4 collects collect VBZ cord-010119-t1x9gknd 2995 5 a a DT cord-010119-t1x9gknd 2995 6 smaller small JJR cord-010119-t1x9gknd 2995 7 volume volume NN cord-010119-t1x9gknd 2995 8 of of IN cord-010119-t1x9gknd 2995 9 a a DT cord-010119-t1x9gknd 2995 10 purer pure JJR cord-010119-t1x9gknd 2995 11 product product NN cord-010119-t1x9gknd 2995 12 when when WRB cord-010119-t1x9gknd 2995 13 compared compare VBN cord-010119-t1x9gknd 2995 14 to to IN cord-010119-t1x9gknd 2995 15 the the DT cord-010119-t1x9gknd 2995 16 MNC MNC NNP cord-010119-t1x9gknd 2995 17 protocol protocol NN cord-010119-t1x9gknd 2995 18 with with IN cord-010119-t1x9gknd 2995 19 comparable comparable JJ cord-010119-t1x9gknd 2995 20 platelet platelet NN cord-010119-t1x9gknd 2995 21 and and CC cord-010119-t1x9gknd 2995 22 red red JJ cord-010119-t1x9gknd 2995 23 blood blood NN cord-010119-t1x9gknd 2995 24 cell cell NN cord-010119-t1x9gknd 2995 25 loss loss NN cord-010119-t1x9gknd 2995 26 . . . cord-010119-t1x9gknd 2996 1 Staff staff NN cord-010119-t1x9gknd 2996 2 members member NNS cord-010119-t1x9gknd 2996 3 who who WP cord-010119-t1x9gknd 2996 4 perform perform VBP cord-010119-t1x9gknd 2996 5 apheresis apheresis NN cord-010119-t1x9gknd 2996 6 procedures procedure NNS cord-010119-t1x9gknd 2996 7 are be VBP cord-010119-t1x9gknd 2996 8 pleased pleased JJ cord-010119-t1x9gknd 2996 9 by by IN cord-010119-t1x9gknd 2996 10 the the DT cord-010119-t1x9gknd 2996 11 shorter short JJR cord-010119-t1x9gknd 2996 12 run run NN cord-010119-t1x9gknd 2996 13 time time NN cord-010119-t1x9gknd 2996 14 . . . cord-010119-t1x9gknd 2997 1 Background Background NNP cord-010119-t1x9gknd 2997 2 / / SYM cord-010119-t1x9gknd 2997 3 Case Case NNP cord-010119-t1x9gknd 2997 4 Studies Studies NNPS cord-010119-t1x9gknd 2997 5 : : : cord-010119-t1x9gknd 2997 6 Hematopoietic Hematopoietic NNP cord-010119-t1x9gknd 2997 7 stem stem NN cord-010119-t1x9gknd 2997 8 cell cell NN cord-010119-t1x9gknd 2997 9 ( ( -LRB- cord-010119-t1x9gknd 2997 10 HSC HSC NNP cord-010119-t1x9gknd 2997 11 ) ) -RRB- cord-010119-t1x9gknd 2997 12 donors donor NNS cord-010119-t1x9gknd 2997 13 and and CC cord-010119-t1x9gknd 2997 14 their -PRON- PRP$ cord-010119-t1x9gknd 2997 15 recipients recipient NNS cord-010119-t1x9gknd 2997 16 need need VBP cord-010119-t1x9gknd 2997 17 not not RB cord-010119-t1x9gknd 2997 18 have have VB cord-010119-t1x9gknd 2997 19 a a DT cord-010119-t1x9gknd 2997 20 matching match VBG cord-010119-t1x9gknd 2997 21 blood blood NN cord-010119-t1x9gknd 2997 22 type type NN cord-010119-t1x9gknd 2997 23 . . . cord-010119-t1x9gknd 2998 1 Eventually eventually RB cord-010119-t1x9gknd 2998 2 , , , cord-010119-t1x9gknd 2998 3 the the DT cord-010119-t1x9gknd 2998 4 HSC HSC NNP cord-010119-t1x9gknd 2998 5 recipient recipient NN cord-010119-t1x9gknd 2998 6 will will MD cord-010119-t1x9gknd 2998 7 become become VB cord-010119-t1x9gknd 2998 8 the the DT cord-010119-t1x9gknd 2998 9 blood blood NN cord-010119-t1x9gknd 2998 10 type type NN cord-010119-t1x9gknd 2998 11 of of IN cord-010119-t1x9gknd 2998 12 the the DT cord-010119-t1x9gknd 2998 13 HSC HSC NNP cord-010119-t1x9gknd 2998 14 donor donor NN cord-010119-t1x9gknd 2998 15 . . . cord-010119-t1x9gknd 2999 1 This this DT cord-010119-t1x9gknd 2999 2 scenario scenario NN cord-010119-t1x9gknd 2999 3 can can MD cord-010119-t1x9gknd 2999 4 become become VB cord-010119-t1x9gknd 2999 5 quite quite PDT cord-010119-t1x9gknd 2999 6 a a DT cord-010119-t1x9gknd 2999 7 conundrum conundrum NN cord-010119-t1x9gknd 2999 8 if if IN cord-010119-t1x9gknd 2999 9 the the DT cord-010119-t1x9gknd 2999 10 HSC HSC NNP cord-010119-t1x9gknd 2999 11 recipient recipient NN cord-010119-t1x9gknd 2999 12 becomes become VBZ cord-010119-t1x9gknd 2999 13 a a DT cord-010119-t1x9gknd 2999 14 patient patient NN cord-010119-t1x9gknd 2999 15 in in IN cord-010119-t1x9gknd 2999 16 need need NN cord-010119-t1x9gknd 2999 17 of of IN cord-010119-t1x9gknd 2999 18 an an DT cord-010119-t1x9gknd 2999 19 organ organ NN cord-010119-t1x9gknd 2999 20 transplant transplant NN cord-010119-t1x9gknd 2999 21 . . . cord-010119-t1x9gknd 3000 1 In in IN cord-010119-t1x9gknd 3000 2 order order NN cord-010119-t1x9gknd 3000 3 for for IN cord-010119-t1x9gknd 3000 4 a a DT cord-010119-t1x9gknd 3000 5 patient patient NN cord-010119-t1x9gknd 3000 6 to to TO cord-010119-t1x9gknd 3000 7 receive receive VB cord-010119-t1x9gknd 3000 8 a a DT cord-010119-t1x9gknd 3000 9 donor donor NN cord-010119-t1x9gknd 3000 10 organ organ NN cord-010119-t1x9gknd 3000 11 , , , cord-010119-t1x9gknd 3000 12 the the DT cord-010119-t1x9gknd 3000 13 patient patient NN cord-010119-t1x9gknd 3000 14 and and CC cord-010119-t1x9gknd 3000 15 donor donor NN cord-010119-t1x9gknd 3000 16 's 's POS cord-010119-t1x9gknd 3000 17 blood blood NN cord-010119-t1x9gknd 3000 18 type type NN cord-010119-t1x9gknd 3000 19 and and CC cord-010119-t1x9gknd 3000 20 HLA HLA NNP cord-010119-t1x9gknd 3000 21 typing typing NN cord-010119-t1x9gknd 3000 22 must must MD cord-010119-t1x9gknd 3000 23 be be VB cord-010119-t1x9gknd 3000 24 compatible compatible JJ cord-010119-t1x9gknd 3000 25 . . . cord-010119-t1x9gknd 3001 1 Study Study NNP cord-010119-t1x9gknd 3001 2 Design Design NNP cord-010119-t1x9gknd 3001 3 / / SYM cord-010119-t1x9gknd 3001 4 Methods method NNS cord-010119-t1x9gknd 3001 5 : : : cord-010119-t1x9gknd 3001 6 Blood blood NN cord-010119-t1x9gknd 3001 7 type type NN cord-010119-t1x9gknd 3001 8 was be VBD cord-010119-t1x9gknd 3001 9 determined determine VBN cord-010119-t1x9gknd 3001 10 using use VBG cord-010119-t1x9gknd 3001 11 gel gel NN cord-010119-t1x9gknd 3001 12 test test NN cord-010119-t1x9gknd 3001 13 cards card NNS cord-010119-t1x9gknd 3001 14 . . . cord-010119-t1x9gknd 3002 1 HLA HLA NNP cord-010119-t1x9gknd 3002 2 typing typing NN cord-010119-t1x9gknd 3002 3 was be VBD cord-010119-t1x9gknd 3002 4 determined determine VBN cord-010119-t1x9gknd 3002 5 by by IN cord-010119-t1x9gknd 3002 6 using use VBG cord-010119-t1x9gknd 3002 7 sequence sequence NN cord-010119-t1x9gknd 3002 8 - - HYPH cord-010119-t1x9gknd 3002 9 specific specific JJ cord-010119-t1x9gknd 3002 10 oligonucleotide oligonucleotide NN cord-010119-t1x9gknd 3002 11 ( ( -LRB- cord-010119-t1x9gknd 3002 12 SSO SSO NNP cord-010119-t1x9gknd 3002 13 ) ) -RRB- cord-010119-t1x9gknd 3002 14 , , , cord-010119-t1x9gknd 3002 15 sequence sequence NN cord-010119-t1x9gknd 3002 16 - - HYPH cord-010119-t1x9gknd 3002 17 specific specific JJ cord-010119-t1x9gknd 3002 18 primer primer NN cord-010119-t1x9gknd 3002 19 ( ( -LRB- cord-010119-t1x9gknd 3002 20 SSP SSP NNP cord-010119-t1x9gknd 3002 21 ) ) -RRB- cord-010119-t1x9gknd 3002 22 , , , cord-010119-t1x9gknd 3002 23 and and CC cord-010119-t1x9gknd 3002 24 sequence sequence NN cord-010119-t1x9gknd 3002 25 based base VBN cord-010119-t1x9gknd 3002 26 typing typing NN cord-010119-t1x9gknd 3002 27 ( ( -LRB- cord-010119-t1x9gknd 3002 28 SBT SBT NNP cord-010119-t1x9gknd 3002 29 ) ) -RRB- cord-010119-t1x9gknd 3002 30 technologies technology NNS cord-010119-t1x9gknd 3002 31 . . . cord-010119-t1x9gknd 3003 1 HSC HSC NNP cord-010119-t1x9gknd 3003 2 sources source NNS cord-010119-t1x9gknd 3003 3 were be VBD cord-010119-t1x9gknd 3003 4 bone bone NN cord-010119-t1x9gknd 3003 5 marrow marrow NN cord-010119-t1x9gknd 3003 6 and and CC cord-010119-t1x9gknd 3003 7 umbilical umbilical JJ cord-010119-t1x9gknd 3003 8 cord cord NN cord-010119-t1x9gknd 3003 9 blood blood NN cord-010119-t1x9gknd 3003 10 . . . cord-010119-t1x9gknd 3004 1 Results result NNS cord-010119-t1x9gknd 3004 2 / / SYM cord-010119-t1x9gknd 3004 3 Findings finding NNS cord-010119-t1x9gknd 3004 4 : : : cord-010119-t1x9gknd 3004 5 Patient Patient NNP cord-010119-t1x9gknd 3004 6 # # NN cord-010119-t1x9gknd 3004 7 1 1 CD cord-010119-t1x9gknd 3004 8 , , , cord-010119-t1x9gknd 3004 9 originally originally RB cord-010119-t1x9gknd 3004 10 typed type VBN cord-010119-t1x9gknd 3004 11 as as IN cord-010119-t1x9gknd 3004 12 an an DT cord-010119-t1x9gknd 3004 13 A2 A2 NNP cord-010119-t1x9gknd 3004 14 , , , cord-010119-t1x9gknd 3004 15 had have VBD cord-010119-t1x9gknd 3004 16 1 1 CD cord-010119-t1x9gknd 3004 17 bone bone NN cord-010119-t1x9gknd 3004 18 marrow marrow NN cord-010119-t1x9gknd 3004 19 donor donor NN cord-010119-t1x9gknd 3004 20 and and CC cord-010119-t1x9gknd 3004 21 2 2 CD cord-010119-t1x9gknd 3004 22 cord cord NN cord-010119-t1x9gknd 3004 23 blood blood NN cord-010119-t1x9gknd 3004 24 transplants transplant NNS cord-010119-t1x9gknd 3004 25 . . . cord-010119-t1x9gknd 3005 1 One one CD cord-010119-t1x9gknd 3005 2 of of IN cord-010119-t1x9gknd 3005 3 the the DT cord-010119-t1x9gknd 3005 4 cord cord NN cord-010119-t1x9gknd 3005 5 blood blood NN cord-010119-t1x9gknd 3005 6 transplants transplant NNS cord-010119-t1x9gknd 3005 7 successfully successfully RB cord-010119-t1x9gknd 3005 8 engrafted engraft VBD cord-010119-t1x9gknd 3005 9 . . . cord-010119-t1x9gknd 3006 1 The the DT cord-010119-t1x9gknd 3006 2 engrafted engrafted JJ cord-010119-t1x9gknd 3006 3 unit unit NN cord-010119-t1x9gknd 3006 4 was be VBD cord-010119-t1x9gknd 3006 5 from from IN cord-010119-t1x9gknd 3006 6 a a DT cord-010119-t1x9gknd 3006 7 type type NN cord-010119-t1x9gknd 3006 8 O o NN cord-010119-t1x9gknd 3006 9 donor donor NN cord-010119-t1x9gknd 3006 10 . . . cord-010119-t1x9gknd 3007 1 Patient patient NN cord-010119-t1x9gknd 3007 2 # # NN cord-010119-t1x9gknd 3007 3 1 1 CD cord-010119-t1x9gknd 3007 4 is be VBZ cord-010119-t1x9gknd 3007 5 now now RB cord-010119-t1x9gknd 3007 6 typing type VBG cord-010119-t1x9gknd 3007 7 as as IN cord-010119-t1x9gknd 3007 8 type type NN cord-010119-t1x9gknd 3007 9 O. O. NNP cord-010119-t1x9gknd 3007 10 Patient Patient NNP cord-010119-t1x9gknd 3007 11 # # NN cord-010119-t1x9gknd 3007 12 2 2 CD cord-010119-t1x9gknd 3007 13 was be VBD cord-010119-t1x9gknd 3007 14 originally originally RB cord-010119-t1x9gknd 3007 15 typed type VBN cord-010119-t1x9gknd 3007 16 as as IN cord-010119-t1x9gknd 3007 17 A2 A2 NNP cord-010119-t1x9gknd 3007 18 and and CC cord-010119-t1x9gknd 3007 19 received receive VBD cord-010119-t1x9gknd 3007 20 a a DT cord-010119-t1x9gknd 3007 21 bone bone NN cord-010119-t1x9gknd 3007 22 marrow marrow NN cord-010119-t1x9gknd 3007 23 transplant transplant NN cord-010119-t1x9gknd 3007 24 from from IN cord-010119-t1x9gknd 3007 25 a a DT cord-010119-t1x9gknd 3007 26 type type NN cord-010119-t1x9gknd 3007 27 B b NN cord-010119-t1x9gknd 3007 28 donor donor NN cord-010119-t1x9gknd 3007 29 . . . cord-010119-t1x9gknd 3008 1 Patient patient NN cord-010119-t1x9gknd 3008 2 # # $ cord-010119-t1x9gknd 3008 3 2 2 CD cord-010119-t1x9gknd 3008 4 is be VBZ cord-010119-t1x9gknd 3008 5 now now RB cord-010119-t1x9gknd 3008 6 front front JJ cord-010119-t1x9gknd 3008 7 - - HYPH cord-010119-t1x9gknd 3008 8 typing typing NN cord-010119-t1x9gknd 3008 9 as as IN cord-010119-t1x9gknd 3008 10 a a DT cord-010119-t1x9gknd 3008 11 B b NN cord-010119-t1x9gknd 3008 12 and and CC cord-010119-t1x9gknd 3008 13 backtyping backtyping NN cord-010119-t1x9gknd 3008 14 as as IN cord-010119-t1x9gknd 3008 15 an an DT cord-010119-t1x9gknd 3008 16 AB ab NN cord-010119-t1x9gknd 3008 17 . . . cord-010119-t1x9gknd 3009 1 Since since IN cord-010119-t1x9gknd 3009 2 the the DT cord-010119-t1x9gknd 3009 3 patient patient NN cord-010119-t1x9gknd 3009 4 's 's POS cord-010119-t1x9gknd 3009 5 ABO ABO NNP cord-010119-t1x9gknd 3009 6 front front NN cord-010119-t1x9gknd 3009 7 and and CC cord-010119-t1x9gknd 3009 8 back back NN cord-010119-t1x9gknd 3009 9 - - HYPH cord-010119-t1x9gknd 3009 10 type type NN cord-010119-t1x9gknd 3009 11 do do VBP cord-010119-t1x9gknd 3009 12 not not RB cord-010119-t1x9gknd 3009 13 match match VB cord-010119-t1x9gknd 3009 14 , , , cord-010119-t1x9gknd 3009 15 a a DT cord-010119-t1x9gknd 3009 16 note note NN cord-010119-t1x9gknd 3009 17 must must MD cord-010119-t1x9gknd 3009 18 be be VB cord-010119-t1x9gknd 3009 19 made make VBN cord-010119-t1x9gknd 3009 20 , , , cord-010119-t1x9gknd 3009 21 that that IN cord-010119-t1x9gknd 3009 22 when when WRB cord-010119-t1x9gknd 3009 23 confirming confirm VBG cord-010119-t1x9gknd 3009 24 ABO ABO NNP cord-010119-t1x9gknd 3009 25 during during IN cord-010119-t1x9gknd 3009 26 crossmatch crossmatch NN cord-010119-t1x9gknd 3009 27 , , , cord-010119-t1x9gknd 3009 28 the the DT cord-010119-t1x9gknd 3009 29 ABO ABO NNP cord-010119-t1x9gknd 3009 30 will will MD cord-010119-t1x9gknd 3009 31 not not RB cord-010119-t1x9gknd 3009 32 match match VB cord-010119-t1x9gknd 3009 33 . . . cord-010119-t1x9gknd 3010 1 The the DT cord-010119-t1x9gknd 3010 2 patient patient NN cord-010119-t1x9gknd 3010 3 now now RB cord-010119-t1x9gknd 3010 4 has have VBZ cord-010119-t1x9gknd 3010 5 an an DT cord-010119-t1x9gknd 3010 6 HLA HLA NNP cord-010119-t1x9gknd 3010 7 and and CC cord-010119-t1x9gknd 3010 8 ABO ABO NNP cord-010119-t1x9gknd 3010 9 identical identical JJ cord-010119-t1x9gknd 3010 10 kidney kidney NN cord-010119-t1x9gknd 3010 11 match match NN cord-010119-t1x9gknd 3010 12 ( ( -LRB- cord-010119-t1x9gknd 3010 13 his -PRON- PRP$ cord-010119-t1x9gknd 3010 14 father father NN cord-010119-t1x9gknd 3010 15 who who WP cord-010119-t1x9gknd 3010 16 is be VBZ cord-010119-t1x9gknd 3010 17 a a DT cord-010119-t1x9gknd 3010 18 type type NN cord-010119-t1x9gknd 3010 19 B b NN cord-010119-t1x9gknd 3010 20 ) ) -RRB- cord-010119-t1x9gknd 3010 21 . . . cord-010119-t1x9gknd 3011 1 Previously previously RB cord-010119-t1x9gknd 3011 2 , , , cord-010119-t1x9gknd 3011 3 the the DT cord-010119-t1x9gknd 3011 4 patient patient NN cord-010119-t1x9gknd 3011 5 and and CC cord-010119-t1x9gknd 3011 6 his -PRON- PRP$ cord-010119-t1x9gknd 3011 7 father father NN cord-010119-t1x9gknd 3011 8 were be VBD cord-010119-t1x9gknd 3011 9 ABO ABO NNP cord-010119-t1x9gknd 3011 10 incompatible incompatible JJ cord-010119-t1x9gknd 3011 11 . . . cord-010119-t1x9gknd 3012 1 The the DT cord-010119-t1x9gknd 3012 2 ABO ABO NNP cord-010119-t1x9gknd 3012 3 and and CC cord-010119-t1x9gknd 3012 4 HLA HLA NNP cord-010119-t1x9gknd 3012 5 results result NNS cord-010119-t1x9gknd 3012 6 on on IN cord-010119-t1x9gknd 3012 7 both both DT cord-010119-t1x9gknd 3012 8 patient patient NN cord-010119-t1x9gknd 3012 9 # # $ cord-010119-t1x9gknd 3012 10 1 1 CD cord-010119-t1x9gknd 3012 11 and and CC cord-010119-t1x9gknd 3012 12 patient patient JJ cord-010119-t1x9gknd 3012 13 # # $ cord-010119-t1x9gknd 3012 14 2 2 CD cord-010119-t1x9gknd 3012 15 indicate indicate VBP cord-010119-t1x9gknd 3012 16 that that IN cord-010119-t1x9gknd 3012 17 the the DT cord-010119-t1x9gknd 3012 18 HSC HSC NNP cord-010119-t1x9gknd 3012 19 transplants transplant NNS cord-010119-t1x9gknd 3012 20 have have VBP cord-010119-t1x9gknd 3012 21 engrafted engraft VBN cord-010119-t1x9gknd 3012 22 . . . cord-010119-t1x9gknd 3013 1 Results result NNS cord-010119-t1x9gknd 3013 2 also also RB cord-010119-t1x9gknd 3013 3 indicate indicate VBP cord-010119-t1x9gknd 3013 4 that that IN cord-010119-t1x9gknd 3013 5 the the DT cord-010119-t1x9gknd 3013 6 ABO ABO NNP cord-010119-t1x9gknd 3013 7 and and CC cord-010119-t1x9gknd 3013 8 HLA HLA NNP cord-010119-t1x9gknd 3013 9 now now RB cord-010119-t1x9gknd 3013 10 match match VBP cord-010119-t1x9gknd 3013 11 that that DT cord-010119-t1x9gknd 3013 12 of of IN cord-010119-t1x9gknd 3013 13 the the DT cord-010119-t1x9gknd 3013 14 donor donor NN cord-010119-t1x9gknd 3013 15 and and CC cord-010119-t1x9gknd 3013 16 differ differ VBP cord-010119-t1x9gknd 3013 17 from from IN cord-010119-t1x9gknd 3013 18 the the DT cord-010119-t1x9gknd 3013 19 recipient recipient NN cord-010119-t1x9gknd 3013 20 's 's POS cord-010119-t1x9gknd 3013 21 original original JJ cord-010119-t1x9gknd 3013 22 ABO ABO NNP cord-010119-t1x9gknd 3013 23 and and CC cord-010119-t1x9gknd 3013 24 HLA HLA NNP cord-010119-t1x9gknd 3013 25 type type NN cord-010119-t1x9gknd 3013 26 . . . cord-010119-t1x9gknd 3014 1 Due due IN cord-010119-t1x9gknd 3014 2 to to IN cord-010119-t1x9gknd 3014 3 various various JJ cord-010119-t1x9gknd 3014 4 reasons reason NNS cord-010119-t1x9gknd 3014 5 , , , cord-010119-t1x9gknd 3014 6 for for IN cord-010119-t1x9gknd 3014 7 example example NN cord-010119-t1x9gknd 3014 8 , , , cord-010119-t1x9gknd 3014 9 a a DT cord-010119-t1x9gknd 3014 10 side side NN cord-010119-t1x9gknd 3014 11 effect effect NN cord-010119-t1x9gknd 3014 12 of of IN cord-010119-t1x9gknd 3014 13 the the DT cord-010119-t1x9gknd 3014 14 immunosuppression immunosuppression NN cord-010119-t1x9gknd 3014 15 , , , cord-010119-t1x9gknd 3014 16 both both DT cord-010119-t1x9gknd 3014 17 patients patient NNS cord-010119-t1x9gknd 3014 18 now now RB cord-010119-t1x9gknd 3014 19 need need VBP cord-010119-t1x9gknd 3014 20 a a DT cord-010119-t1x9gknd 3014 21 kidney kidney NN cord-010119-t1x9gknd 3014 22 transplant transplant NN cord-010119-t1x9gknd 3014 23 . . . cord-010119-t1x9gknd 3015 1 Both both DT cord-010119-t1x9gknd 3015 2 patients patient NNS cord-010119-t1x9gknd 3015 3 will will MD cord-010119-t1x9gknd 3015 4 be be VB cord-010119-t1x9gknd 3015 5 entered enter VBN cord-010119-t1x9gknd 3015 6 into into IN cord-010119-t1x9gknd 3015 7 the the DT cord-010119-t1x9gknd 3015 8 UNet UNet NNP cord-010119-t1x9gknd 3015 9 system system NN cord-010119-t1x9gknd 3015 10 according accord VBG cord-010119-t1x9gknd 3015 11 to to IN cord-010119-t1x9gknd 3015 12 their -PRON- PRP$ cord-010119-t1x9gknd 3015 13 " " `` cord-010119-t1x9gknd 3015 14 new new JJ cord-010119-t1x9gknd 3015 15 " " '' cord-010119-t1x9gknd 3015 16 ABO ABO NNP cord-010119-t1x9gknd 3015 17 and and CC cord-010119-t1x9gknd 3015 18 HLA HLA NNP cord-010119-t1x9gknd 3015 19 types type NNS cord-010119-t1x9gknd 3015 20 , , , cord-010119-t1x9gknd 3015 21 as as IN cord-010119-t1x9gknd 3015 22 UNOS UNOS NNP cord-010119-t1x9gknd 3015 23 regulations regulation NNS cord-010119-t1x9gknd 3015 24 require require VBP cord-010119-t1x9gknd 3015 25 patients patient NNS cord-010119-t1x9gknd 3015 26 to to TO cord-010119-t1x9gknd 3015 27 be be VB cord-010119-t1x9gknd 3015 28 listed list VBN cord-010119-t1x9gknd 3015 29 as as IN cord-010119-t1x9gknd 3015 30 per per IN cord-010119-t1x9gknd 3015 31 the the DT cord-010119-t1x9gknd 3015 32 results result NNS cord-010119-t1x9gknd 3015 33 of of IN cord-010119-t1x9gknd 3015 34 two two CD cord-010119-t1x9gknd 3015 35 separate separate JJ cord-010119-t1x9gknd 3015 36 ABO ABO NNP cord-010119-t1x9gknd 3015 37 typing typing NN cord-010119-t1x9gknd 3015 38 tests test NNS cord-010119-t1x9gknd 3015 39 . . . cord-010119-t1x9gknd 3016 1 The the DT cord-010119-t1x9gknd 3016 2 patients patient NNS cord-010119-t1x9gknd 3016 3 ' ' POS cord-010119-t1x9gknd 3016 4 antibodies antibody NNS cord-010119-t1x9gknd 3016 5 will will MD cord-010119-t1x9gknd 3016 6 be be VB cord-010119-t1x9gknd 3016 7 monitored monitor VBN cord-010119-t1x9gknd 3016 8 as as IN cord-010119-t1x9gknd 3016 9 per per IN cord-010119-t1x9gknd 3016 10 lab lab NN cord-010119-t1x9gknd 3016 11 policy policy NN cord-010119-t1x9gknd 3016 12 and and CC cord-010119-t1x9gknd 3016 13 communication communication NN cord-010119-t1x9gknd 3016 14 with with IN cord-010119-t1x9gknd 3016 15 the the DT cord-010119-t1x9gknd 3016 16 transplant transplant NN cord-010119-t1x9gknd 3016 17 centers center NNS cord-010119-t1x9gknd 3016 18 and and CC cord-010119-t1x9gknd 3016 19 blood blood NN cord-010119-t1x9gknd 3016 20 banks bank NNS cord-010119-t1x9gknd 3016 21 is be VBZ cord-010119-t1x9gknd 3016 22 crucial crucial JJ cord-010119-t1x9gknd 3016 23 . . . cord-010119-t1x9gknd 3017 1 Background Background NNP cord-010119-t1x9gknd 3017 2 / / SYM cord-010119-t1x9gknd 3017 3 Case Case NNP cord-010119-t1x9gknd 3017 4 Studies Studies NNPS cord-010119-t1x9gknd 3017 5 : : : cord-010119-t1x9gknd 3018 1 Mesenchymal Mesenchymal NNS cord-010119-t1x9gknd 3018 2 stem stem VBP cord-010119-t1x9gknd 3018 3 cells cell NNS cord-010119-t1x9gknd 3018 4 ( ( -LRB- cord-010119-t1x9gknd 3018 5 MSC MSC NNP cord-010119-t1x9gknd 3018 6 ) ) -RRB- cord-010119-t1x9gknd 3018 7 are be VBP cord-010119-t1x9gknd 3018 8 beneficial beneficial JJ cord-010119-t1x9gknd 3018 9 for for IN cord-010119-t1x9gknd 3018 10 tissue tissue NN cord-010119-t1x9gknd 3018 11 regeneration regeneration NN cord-010119-t1x9gknd 3018 12 , , , cord-010119-t1x9gknd 3018 13 immunomodulation immunomodulation NN cord-010119-t1x9gknd 3018 14 and and CC cord-010119-t1x9gknd 3018 15 improvement improvement NN cord-010119-t1x9gknd 3018 16 of of IN cord-010119-t1x9gknd 3018 17 multiple multiple JJ cord-010119-t1x9gknd 3018 18 organ organ NN cord-010119-t1x9gknd 3018 19 failure failure NN cord-010119-t1x9gknd 3018 20 caused cause VBN cord-010119-t1x9gknd 3018 21 by by IN cord-010119-t1x9gknd 3018 22 infection infection NN cord-010119-t1x9gknd 3018 23 , , , cord-010119-t1x9gknd 3018 24 sepsis sepsis NN cord-010119-t1x9gknd 3018 25 , , , cord-010119-t1x9gknd 3018 26 and and CC cord-010119-t1x9gknd 3018 27 trauma trauma NN cord-010119-t1x9gknd 3018 28 . . . cord-010119-t1x9gknd 3019 1 MSCs msc NNS cord-010119-t1x9gknd 3019 2 express express JJ cord-010119-t1x9gknd 3019 3 tissue tissue NN cord-010119-t1x9gknd 3019 4 factor factor NN cord-010119-t1x9gknd 3019 5 ( ( -LRB- cord-010119-t1x9gknd 3019 6 TF TF NNP cord-010119-t1x9gknd 3019 7 ) ) -RRB- cord-010119-t1x9gknd 3019 8 that that WDT cord-010119-t1x9gknd 3019 9 activate activate VBP cord-010119-t1x9gknd 3019 10 the the DT cord-010119-t1x9gknd 3019 11 clotting clotting NN cord-010119-t1x9gknd 3019 12 cascade cascade NN cord-010119-t1x9gknd 3019 13 and and CC cord-010119-t1x9gknd 3019 14 interfere interfere VB cord-010119-t1x9gknd 3019 15 hemostasis hemostasis NN cord-010119-t1x9gknd 3019 16 . . . cord-010119-t1x9gknd 3020 1 Hypoxia hypoxia NN cord-010119-t1x9gknd 3020 2 is be VBZ cord-010119-t1x9gknd 3020 3 a a DT cord-010119-t1x9gknd 3020 4 condition condition NN cord-010119-t1x9gknd 3020 5 that that WDT cord-010119-t1x9gknd 3020 6 occurs occur VBZ cord-010119-t1x9gknd 3020 7 after after IN cord-010119-t1x9gknd 3020 8 trauma trauma NN cord-010119-t1x9gknd 3020 9 globally globally RB cord-010119-t1x9gknd 3020 10 during during IN cord-010119-t1x9gknd 3020 11 shock shock NN cord-010119-t1x9gknd 3020 12 or or CC cord-010119-t1x9gknd 3020 13 at at IN cord-010119-t1x9gknd 3020 14 the the DT cord-010119-t1x9gknd 3020 15 site site NN cord-010119-t1x9gknd 3020 16 of of IN cord-010119-t1x9gknd 3020 17 injury injury NN cord-010119-t1x9gknd 3020 18 , , , cord-010119-t1x9gknd 3020 19 and and CC cord-010119-t1x9gknd 3020 20 is be VBZ cord-010119-t1x9gknd 3020 21 known know VBN cord-010119-t1x9gknd 3020 22 to to TO cord-010119-t1x9gknd 3020 23 change change VB cord-010119-t1x9gknd 3020 24 or or CC cord-010119-t1x9gknd 3020 25 influence influence VB cord-010119-t1x9gknd 3020 26 the the DT cord-010119-t1x9gknd 3020 27 phenotypes phenotype NNS cord-010119-t1x9gknd 3020 28 of of IN cord-010119-t1x9gknd 3020 29 cells cell NNS cord-010119-t1x9gknd 3020 30 , , , cord-010119-t1x9gknd 3020 31 including include VBG cord-010119-t1x9gknd 3020 32 MSCs msc NNS cord-010119-t1x9gknd 3020 33 . . . cord-010119-t1x9gknd 3021 1 In in IN cord-010119-t1x9gknd 3021 2 this this DT cord-010119-t1x9gknd 3021 3 study study NN cord-010119-t1x9gknd 3021 4 , , , cord-010119-t1x9gknd 3021 5 we -PRON- PRP cord-010119-t1x9gknd 3021 6 want want VBP cord-010119-t1x9gknd 3021 7 to to TO cord-010119-t1x9gknd 3021 8 determine determine VB cord-010119-t1x9gknd 3021 9 if if IN cord-010119-t1x9gknd 3021 10 hypoxia hypoxia NN cord-010119-t1x9gknd 3021 11 changes change VBZ cord-010119-t1x9gknd 3021 12 the the DT cord-010119-t1x9gknd 3021 13 expression expression NN cord-010119-t1x9gknd 3021 14 of of IN cord-010119-t1x9gknd 3021 15 tissue tissue NN cord-010119-t1x9gknd 3021 16 factor factor NN cord-010119-t1x9gknd 3021 17 and and CC cord-010119-t1x9gknd 3021 18 the the DT cord-010119-t1x9gknd 3021 19 pro pro JJ cord-010119-t1x9gknd 3021 20 - - JJ cord-010119-t1x9gknd 3021 21 coagulant coagulant JJ cord-010119-t1x9gknd 3021 22 properties property NNS cord-010119-t1x9gknd 3021 23 of of IN cord-010119-t1x9gknd 3021 24 rat rat NN cord-010119-t1x9gknd 3021 25 MSC MSC NNP cord-010119-t1x9gknd 3021 26 in in IN cord-010119-t1x9gknd 3021 27 vitro vitro FW cord-010119-t1x9gknd 3021 28 . . . cord-010119-t1x9gknd 3022 1 Study Study NNP cord-010119-t1x9gknd 3022 2 Design Design NNP cord-010119-t1x9gknd 3022 3 / / SYM cord-010119-t1x9gknd 3022 4 Method method NN cord-010119-t1x9gknd 3022 5 : : : cord-010119-t1x9gknd 3023 1 Bone bone NN cord-010119-t1x9gknd 3023 2 marrow marrow NN cord-010119-t1x9gknd 3023 3 and and CC cord-010119-t1x9gknd 3023 4 adipose adipose NN cord-010119-t1x9gknd 3023 5 derived derive VBN cord-010119-t1x9gknd 3023 6 MSCs mscs NN cord-010119-t1x9gknd 3023 7 ( ( -LRB- cord-010119-t1x9gknd 3023 8 BMSC BMSC NNP cord-010119-t1x9gknd 3023 9 and and CC cord-010119-t1x9gknd 3023 10 AMSC AMSC NNP cord-010119-t1x9gknd 3023 11 ) ) -RRB- cord-010119-t1x9gknd 3023 12 were be VBD cord-010119-t1x9gknd 3023 13 isolated isolate VBN cord-010119-t1x9gknd 3023 14 from from IN cord-010119-t1x9gknd 3023 15 bones bone NNS cord-010119-t1x9gknd 3023 16 ( ( -LRB- cord-010119-t1x9gknd 3023 17 femur femur NN cord-010119-t1x9gknd 3023 18 and and CC cord-010119-t1x9gknd 3023 19 tibia tibia NN cord-010119-t1x9gknd 3023 20 ) ) -RRB- cord-010119-t1x9gknd 3023 21 and and CC cord-010119-t1x9gknd 3023 22 visceral visceral JJ cord-010119-t1x9gknd 3023 23 fat fat JJ cord-010119-t1x9gknd 3023 24 tissue tissue NN cord-010119-t1x9gknd 3023 25 in in IN cord-010119-t1x9gknd 3023 26 normal normal JJ cord-010119-t1x9gknd 3023 27 young young JJ cord-010119-t1x9gknd 3023 28 Sprague Sprague NNP cord-010119-t1x9gknd 3023 29 Dawley Dawley NNP cord-010119-t1x9gknd 3023 30 rats rat NNS cord-010119-t1x9gknd 3023 31 respectively respectively RB cord-010119-t1x9gknd 3023 32 . . . cord-010119-t1x9gknd 3024 1 Both both DT cord-010119-t1x9gknd 3024 2 BMSCs bmsc NNS cord-010119-t1x9gknd 3024 3 and and CC cord-010119-t1x9gknd 3024 4 AMSCs amsc NNS cord-010119-t1x9gknd 3024 5 were be VBD cord-010119-t1x9gknd 3024 6 cultured culture VBN cord-010119-t1x9gknd 3024 7 using use VBG cord-010119-t1x9gknd 3024 8 DMEM DMEM NNP cord-010119-t1x9gknd 3024 9 medium medium NN cord-010119-t1x9gknd 3024 10 with with IN cord-010119-t1x9gknd 3024 11 20 20 CD cord-010119-t1x9gknd 3024 12 % % NN cord-010119-t1x9gknd 3024 13 fetal fetal JJ cord-010119-t1x9gknd 3024 14 bovine bovine JJ cord-010119-t1x9gknd 3024 15 serum serum NN cord-010119-t1x9gknd 3024 16 under under IN cord-010119-t1x9gknd 3024 17 either either DT cord-010119-t1x9gknd 3024 18 normoxia normoxia NNP cord-010119-t1x9gknd 3024 19 ( ( -LRB- cord-010119-t1x9gknd 3024 20 20 20 CD cord-010119-t1x9gknd 3024 21 % % NN cord-010119-t1x9gknd 3024 22 O o NN cord-010119-t1x9gknd 3024 23 2 2 CD cord-010119-t1x9gknd 3024 24 ) ) -RRB- cord-010119-t1x9gknd 3024 25 or or CC cord-010119-t1x9gknd 3024 26 hypoxia hypoxia NN cord-010119-t1x9gknd 3024 27 ( ( -LRB- cord-010119-t1x9gknd 3024 28 3.5 3.5 CD cord-010119-t1x9gknd 3024 29 % % NN cord-010119-t1x9gknd 3024 30 O o NN cord-010119-t1x9gknd 3024 31 2 2 CD cord-010119-t1x9gknd 3024 32 ) ) -RRB- cord-010119-t1x9gknd 3024 33 . . . cord-010119-t1x9gknd 3025 1 MSC MSC NNP cord-010119-t1x9gknd 3025 2 growth growth NN cord-010119-t1x9gknd 3025 3 curves curve NNS cord-010119-t1x9gknd 3025 4 were be VBD cord-010119-t1x9gknd 3025 5 measured measure VBN cord-010119-t1x9gknd 3025 6 by by IN cord-010119-t1x9gknd 3025 7 cell cell NN cord-010119-t1x9gknd 3025 8 counter counter NN cord-010119-t1x9gknd 3025 9 . . . cord-010119-t1x9gknd 3026 1 The the DT cord-010119-t1x9gknd 3026 2 TF TF NNP cord-010119-t1x9gknd 3026 3 expression expression NN cord-010119-t1x9gknd 3026 4 was be VBD cord-010119-t1x9gknd 3026 5 determined determine VBN cord-010119-t1x9gknd 3026 6 by by IN cord-010119-t1x9gknd 3026 7 immunohistochemistry immunohistochemistry NN cord-010119-t1x9gknd 3026 8 . . . cord-010119-t1x9gknd 3027 1 CD90 CD90 NNP cord-010119-t1x9gknd 3027 2 / / SYM cord-010119-t1x9gknd 3027 3 CD29 CD29 NNP cord-010119-t1x9gknd 3027 4 and and CC cord-010119-t1x9gknd 3027 5 CD45 CD45 NNP cord-010119-t1x9gknd 3027 6 were be VBD cord-010119-t1x9gknd 3027 7 measured measure VBN cord-010119-t1x9gknd 3027 8 as as IN cord-010119-t1x9gknd 3027 9 positive positive JJ cord-010119-t1x9gknd 3027 10 and and CC cord-010119-t1x9gknd 3027 11 negative negative JJ cord-010119-t1x9gknd 3027 12 markers marker NNS cord-010119-t1x9gknd 3027 13 of of IN cord-010119-t1x9gknd 3027 14 MSC MSC NNP cord-010119-t1x9gknd 3027 15 respectively respectively RB cord-010119-t1x9gknd 3027 16 by by IN cord-010119-t1x9gknd 3027 17 flow flow NN cord-010119-t1x9gknd 3027 18 cytometry cytometry NN cord-010119-t1x9gknd 3027 19 . . . cord-010119-t1x9gknd 3028 1 The the DT cord-010119-t1x9gknd 3028 2 citrated citrate VBN cord-010119-t1x9gknd 3028 3 rat rat NN cord-010119-t1x9gknd 3028 4 whole whole JJ cord-010119-t1x9gknd 3028 5 blood blood NN cord-010119-t1x9gknd 3028 6 was be VBD cord-010119-t1x9gknd 3028 7 treated treat VBN cord-010119-t1x9gknd 3028 8 with with IN cord-010119-t1x9gknd 3028 9 MSC MSC NNP cord-010119-t1x9gknd 3028 10 ( ( -LRB- cord-010119-t1x9gknd 3028 11 1.5 1.5 CD cord-010119-t1x9gknd 3028 12 3 3 CD cord-010119-t1x9gknd 3028 13 10 10 CD cord-010119-t1x9gknd 3028 14 5 5 CD cord-010119-t1x9gknd 3028 15 /ml /ml . cord-010119-t1x9gknd 3028 16 ) ) -RRB- cord-010119-t1x9gknd 3029 1 either either CC cord-010119-t1x9gknd 3029 2 from from IN cord-010119-t1x9gknd 3029 3 normoxia normoxia NN cord-010119-t1x9gknd 3029 4 or or CC cord-010119-t1x9gknd 3029 5 hypoxia hypoxia NN cord-010119-t1x9gknd 3029 6 . . . cord-010119-t1x9gknd 3030 1 The the DT cord-010119-t1x9gknd 3030 2 coagulation coagulation NN cord-010119-t1x9gknd 3030 3 properties property NNS cord-010119-t1x9gknd 3030 4 were be VBD cord-010119-t1x9gknd 3030 5 measured measure VBN cord-010119-t1x9gknd 3030 6 by by IN cord-010119-t1x9gknd 3030 7 hemostasis hemostasis NN cord-010119-t1x9gknd 3030 8 analyzer analyzer NN cord-010119-t1x9gknd 3030 9 and and CC cord-010119-t1x9gknd 3030 10 rotational rotational JJ cord-010119-t1x9gknd 3030 11 thromboelastometry thromboelastometry NN cord-010119-t1x9gknd 3030 12 ( ( -LRB- cord-010119-t1x9gknd 3030 13 ROTEM ROTEM NNP cord-010119-t1x9gknd 3030 14 ) ) -RRB- cord-010119-t1x9gknd 3030 15 . . . cord-010119-t1x9gknd 3031 1 Results/ Results/ . cord-010119-t1x9gknd 3032 1 Finding finding NN cord-010119-t1x9gknd 3032 2 : : : cord-010119-t1x9gknd 3033 1 Hypoxia hypoxia NN cord-010119-t1x9gknd 3033 2 potentiated potentiate VBD cord-010119-t1x9gknd 3033 3 the the DT cord-010119-t1x9gknd 3033 4 growth growth NN cord-010119-t1x9gknd 3033 5 of of IN cord-010119-t1x9gknd 3033 6 BMSC BMSC NNP cord-010119-t1x9gknd 3033 7 by by IN cord-010119-t1x9gknd 3033 8 15 15 CD cord-010119-t1x9gknd 3033 9 % % NN cord-010119-t1x9gknd 3033 10 , , , cord-010119-t1x9gknd 3033 11 but but CC cord-010119-t1x9gknd 3033 12 depressed depress VBD cord-010119-t1x9gknd 3033 13 the the DT cord-010119-t1x9gknd 3033 14 growth growth NN cord-010119-t1x9gknd 3033 15 of of IN cord-010119-t1x9gknd 3033 16 AMSC AMSC NNP cord-010119-t1x9gknd 3033 17 by by IN cord-010119-t1x9gknd 3033 18 30 30 CD cord-010119-t1x9gknd 3033 19 % % NN cord-010119-t1x9gknd 3033 20 at at IN cord-010119-t1x9gknd 3033 21 day day NN cord-010119-t1x9gknd 3033 22 5 5 CD cord-010119-t1x9gknd 3033 23 in in IN cord-010119-t1x9gknd 3033 24 comparison comparison NN cord-010119-t1x9gknd 3033 25 to to TO cord-010119-t1x9gknd 3033 26 normoxia normoxia VB cord-010119-t1x9gknd 3033 27 . . . cord-010119-t1x9gknd 3034 1 Both both DT cord-010119-t1x9gknd 3034 2 BMSC BMSC NNP cord-010119-t1x9gknd 3034 3 and and CC cord-010119-t1x9gknd 3034 4 AMSC AMSC NNP cord-010119-t1x9gknd 3034 5 equally equally RB cord-010119-t1x9gknd 3034 6 expressed express VBD cord-010119-t1x9gknd 3034 7 CD90 CD90 NNP cord-010119-t1x9gknd 3034 8 and and CC cord-010119-t1x9gknd 3034 9 CD29 CD29 NNP cord-010119-t1x9gknd 3034 10 but but CC cord-010119-t1x9gknd 3034 11 not not RB cord-010119-t1x9gknd 3034 12 CD45 CD45 NNP cord-010119-t1x9gknd 3034 13 under under IN cord-010119-t1x9gknd 3034 14 any any DT cord-010119-t1x9gknd 3034 15 culture culture NN cord-010119-t1x9gknd 3034 16 condition condition NN cord-010119-t1x9gknd 3034 17 . . . cord-010119-t1x9gknd 3035 1 Tissue tissue NN cord-010119-t1x9gknd 3035 2 factor factor NN cord-010119-t1x9gknd 3035 3 was be VBD cord-010119-t1x9gknd 3035 4 significantly significantly RB cord-010119-t1x9gknd 3035 5 expressed express VBN cord-010119-t1x9gknd 3035 6 among among IN cord-010119-t1x9gknd 3035 7 BMSCs bmsc NNS cord-010119-t1x9gknd 3035 8 and and CC cord-010119-t1x9gknd 3035 9 AMSCs amsc NNS cord-010119-t1x9gknd 3035 10 from from IN cord-010119-t1x9gknd 3035 11 both both DT cord-010119-t1x9gknd 3035 12 normoxia normoxia NN cord-010119-t1x9gknd 3035 13 and and CC cord-010119-t1x9gknd 3035 14 hypoxia hypoxia NN cord-010119-t1x9gknd 3035 15 . . . cord-010119-t1x9gknd 3036 1 Whole whole JJ cord-010119-t1x9gknd 3036 2 blood blood NN cord-010119-t1x9gknd 3036 3 treated treat VBN cord-010119-t1x9gknd 3036 4 with with IN cord-010119-t1x9gknd 3036 5 BMSCs bmsc NNS cord-010119-t1x9gknd 3036 6 and and CC cord-010119-t1x9gknd 3036 7 AMSCs amsc NNS cord-010119-t1x9gknd 3036 8 from from IN cord-010119-t1x9gknd 3036 9 normoxia normoxia NNP cord-010119-t1x9gknd 3036 10 significantly significantly RB cord-010119-t1x9gknd 3036 11 shortened shorten VBD cord-010119-t1x9gknd 3036 12 the the DT cord-010119-t1x9gknd 3036 13 clotting clotting NN cord-010119-t1x9gknd 3036 14 time time NN cord-010119-t1x9gknd 3036 15 ( ( -LRB- cord-010119-t1x9gknd 3036 16 CT CT NNP cord-010119-t1x9gknd 3036 17 : : : cord-010119-t1x9gknd 3036 18 468 468 CD cord-010119-t1x9gknd 3036 19 6 6 CD cord-010119-t1x9gknd 3036 20 64 64 CD cord-010119-t1x9gknd 3036 21 ( ( -LRB- cord-010119-t1x9gknd 3036 22 control control NN cord-010119-t1x9gknd 3036 23 ) ) -RRB- cord-010119-t1x9gknd 3036 24 , , , cord-010119-t1x9gknd 3036 25 versus versus IN cord-010119-t1x9gknd 3036 26 170 170 CD cord-010119-t1x9gknd 3036 27 6 6 CD cord-010119-t1x9gknd 3036 28 13 13 CD cord-010119-t1x9gknd 3036 29 ( ( -LRB- cord-010119-t1x9gknd 3036 30 BMSC BMSC NNP cord-010119-t1x9gknd 3036 31 ) ) -RRB- cord-010119-t1x9gknd 3036 32 , , , cord-010119-t1x9gknd 3036 33 and and CC cord-010119-t1x9gknd 3036 34 195 195 CD cord-010119-t1x9gknd 3036 35 6 6 CD cord-010119-t1x9gknd 3036 36 60 60 CD cord-010119-t1x9gknd 3036 37 ( ( -LRB- cord-010119-t1x9gknd 3036 38 AMSC AMSC NNP cord-010119-t1x9gknd 3036 39 ) ) -RRB- cord-010119-t1x9gknd 3036 40 seconds second NNS cord-010119-t1x9gknd 3036 41 ) ) -RRB- cord-010119-t1x9gknd 3036 42 by by IN cord-010119-t1x9gknd 3036 43 NATEM NATEM NNP cord-010119-t1x9gknd 3036 44 . . . cord-010119-t1x9gknd 3037 1 Hypoxia hypoxia NN cord-010119-t1x9gknd 3037 2 also also RB cord-010119-t1x9gknd 3037 3 significantly significantly RB cord-010119-t1x9gknd 3037 4 shortened shorten VBN cord-010119-t1x9gknd 3037 5 CT CT NNP cord-010119-t1x9gknd 3037 6 ( ( -LRB- cord-010119-t1x9gknd 3037 7 165 165 CD cord-010119-t1x9gknd 3037 8 6 6 CD cord-010119-t1x9gknd 3037 9 20 20 CD cord-010119-t1x9gknd 3037 10 ( ( -LRB- cord-010119-t1x9gknd 3037 11 BMSC BMSC NNP cord-010119-t1x9gknd 3037 12 ) ) -RRB- cord-010119-t1x9gknd 3037 13 , , , cord-010119-t1x9gknd 3037 14 169 169 CD cord-010119-t1x9gknd 3037 15 6 6 CD cord-010119-t1x9gknd 3037 16 50 50 CD cord-010119-t1x9gknd 3037 17 ( ( -LRB- cord-010119-t1x9gknd 3037 18 AMSC AMSC NNP cord-010119-t1x9gknd 3037 19 ) ) -RRB- cord-010119-t1x9gknd 3037 20 seconds second NNS cord-010119-t1x9gknd 3037 21 , , , cord-010119-t1x9gknd 3037 22 p<0.05 p<0.05 NN cord-010119-t1x9gknd 3037 23 as as IN cord-010119-t1x9gknd 3037 24 compared compare VBN cord-010119-t1x9gknd 3037 25 to to IN cord-010119-t1x9gknd 3037 26 control control NN cord-010119-t1x9gknd 3037 27 ) ) -RRB- cord-010119-t1x9gknd 3037 28 , , , cord-010119-t1x9gknd 3037 29 but but CC cord-010119-t1x9gknd 3037 30 the the DT cord-010119-t1x9gknd 3037 31 changes change NNS cord-010119-t1x9gknd 3037 32 in in IN cord-010119-t1x9gknd 3037 33 CT CT NNP cord-010119-t1x9gknd 3037 34 were be VBD cord-010119-t1x9gknd 3037 35 not not RB cord-010119-t1x9gknd 3037 36 significantly significantly RB cord-010119-t1x9gknd 3037 37 different different JJ cord-010119-t1x9gknd 3037 38 between between IN cord-010119-t1x9gknd 3037 39 BMSCs bmsc NNS cord-010119-t1x9gknd 3037 40 and and CC cord-010119-t1x9gknd 3037 41 AMSCs amsc NNS cord-010119-t1x9gknd 3037 42 . . . cord-010119-t1x9gknd 3038 1 Maximum maximum JJ cord-010119-t1x9gknd 3038 2 clot clot NN cord-010119-t1x9gknd 3038 3 firmness firmness NN cord-010119-t1x9gknd 3038 4 ( ( -LRB- cord-010119-t1x9gknd 3038 5 MCF MCF NNP cord-010119-t1x9gknd 3038 6 ) ) -RRB- cord-010119-t1x9gknd 3038 7 and and CC cord-010119-t1x9gknd 3038 8 fibrinolytic fibrinolytic JJ cord-010119-t1x9gknd 3038 9 index index NN cord-010119-t1x9gknd 3038 10 did do VBD cord-010119-t1x9gknd 3038 11 not not RB cord-010119-t1x9gknd 3038 12 change change VB cord-010119-t1x9gknd 3038 13 after after IN cord-010119-t1x9gknd 3038 14 treatment treatment NN cord-010119-t1x9gknd 3038 15 with with IN cord-010119-t1x9gknd 3038 16 BMSC BMSC NNP cord-010119-t1x9gknd 3038 17 and and CC cord-010119-t1x9gknd 3038 18 AMSC AMSC NNP cord-010119-t1x9gknd 3038 19 regardless regardless RB cord-010119-t1x9gknd 3038 20 of of IN cord-010119-t1x9gknd 3038 21 the the DT cord-010119-t1x9gknd 3038 22 normoxia normoxia NN cord-010119-t1x9gknd 3038 23 or or CC cord-010119-t1x9gknd 3038 24 hypoxia hypoxia NN cord-010119-t1x9gknd 3038 25 conditions condition NNS cord-010119-t1x9gknd 3038 26 . . . cord-010119-t1x9gknd 3039 1 Conclusion conclusion NN cord-010119-t1x9gknd 3039 2 : : : cord-010119-t1x9gknd 3040 1 Tissue tissue NN cord-010119-t1x9gknd 3040 2 factor factor NN cord-010119-t1x9gknd 3040 3 is be VBZ cord-010119-t1x9gknd 3040 4 constitutively constitutively RB cord-010119-t1x9gknd 3040 5 expressed express VBN cord-010119-t1x9gknd 3040 6 in in IN cord-010119-t1x9gknd 3040 7 rat rat NN cord-010119-t1x9gknd 3040 8 BMSCs bmsc NNS cord-010119-t1x9gknd 3040 9 and and CC cord-010119-t1x9gknd 3040 10 AMSCs amsc NNS cord-010119-t1x9gknd 3040 11 . . . cord-010119-t1x9gknd 3041 1 Adjustment adjustment NN cord-010119-t1x9gknd 3041 2 of of IN cord-010119-t1x9gknd 3041 3 the the DT cord-010119-t1x9gknd 3041 4 MSC MSC NNP cord-010119-t1x9gknd 3041 5 culture culture NN cord-010119-t1x9gknd 3041 6 condition condition NN cord-010119-t1x9gknd 3041 7 to to IN cord-010119-t1x9gknd 3041 8 hypoxia hypoxia NN cord-010119-t1x9gknd 3041 9 did do VBD cord-010119-t1x9gknd 3041 10 not not RB cord-010119-t1x9gknd 3041 11 affect affect VB cord-010119-t1x9gknd 3041 12 tissue tissue NN cord-010119-t1x9gknd 3041 13 factor factor NN cord-010119-t1x9gknd 3041 14 expression expression NN cord-010119-t1x9gknd 3041 15 or or CC cord-010119-t1x9gknd 3041 16 the the DT cord-010119-t1x9gknd 3041 17 procoagulant procoagulant JJ cord-010119-t1x9gknd 3041 18 properties property NNS cord-010119-t1x9gknd 3041 19 of of IN cord-010119-t1x9gknd 3041 20 MSC MSC NNP cord-010119-t1x9gknd 3041 21 ( ( -LRB- cord-010119-t1x9gknd 3041 22 BMSC BMSC NNP cord-010119-t1x9gknd 3041 23 and and CC cord-010119-t1x9gknd 3041 24 AMSC AMSC NNP cord-010119-t1x9gknd 3041 25 ) ) -RRB- cord-010119-t1x9gknd 3041 26 . . . cord-010119-t1x9gknd 3042 1 This this DT cord-010119-t1x9gknd 3042 2 study study NN cord-010119-t1x9gknd 3042 3 also also RB cord-010119-t1x9gknd 3042 4 suggests suggest VBZ cord-010119-t1x9gknd 3042 5 that that IN cord-010119-t1x9gknd 3042 6 the the DT cord-010119-t1x9gknd 3042 7 procoagulant procoagulant NN cord-010119-t1x9gknd 3042 8 properties property NNS cord-010119-t1x9gknd 3042 9 will will MD cord-010119-t1x9gknd 3042 10 not not RB cord-010119-t1x9gknd 3042 11 be be VB cord-010119-t1x9gknd 3042 12 affected affect VBN cord-010119-t1x9gknd 3042 13 if if IN cord-010119-t1x9gknd 3042 14 MSCs msc NNS cord-010119-t1x9gknd 3042 15 are be VBP cord-010119-t1x9gknd 3042 16 recruited recruit VBN cord-010119-t1x9gknd 3042 17 into into IN cord-010119-t1x9gknd 3042 18 injured injured JJ cord-010119-t1x9gknd 3042 19 tissues tissue NNS cord-010119-t1x9gknd 3042 20 with with IN cord-010119-t1x9gknd 3042 21 hypoxic hypoxic JJ cord-010119-t1x9gknd 3042 22 environments environment NNS cord-010119-t1x9gknd 3042 23 . . . cord-010119-t1x9gknd 3043 1 Future future JJ cord-010119-t1x9gknd 3043 2 study study NN cord-010119-t1x9gknd 3043 3 will will MD cord-010119-t1x9gknd 3043 4 be be VB cord-010119-t1x9gknd 3043 5 necessary necessary JJ cord-010119-t1x9gknd 3043 6 to to TO cord-010119-t1x9gknd 3043 7 determine determine VB cord-010119-t1x9gknd 3043 8 the the DT cord-010119-t1x9gknd 3043 9 optimal optimal JJ cord-010119-t1x9gknd 3043 10 dose dose NN cord-010119-t1x9gknd 3043 11 MSC MSC NNP cord-010119-t1x9gknd 3043 12 and and CC cord-010119-t1x9gknd 3043 13 whether whether IN cord-010119-t1x9gknd 3043 14 it -PRON- PRP cord-010119-t1x9gknd 3043 15 is be VBZ cord-010119-t1x9gknd 3043 16 safe safe JJ cord-010119-t1x9gknd 3043 17 to to TO cord-010119-t1x9gknd 3043 18 use use VB cord-010119-t1x9gknd 3043 19 MSCs msc NNS cord-010119-t1x9gknd 3043 20 for for IN cord-010119-t1x9gknd 3043 21 systemic systemic JJ cord-010119-t1x9gknd 3043 22 application application NN cord-010119-t1x9gknd 3043 23 in in IN cord-010119-t1x9gknd 3043 24 trauma trauma NN cord-010119-t1x9gknd 3043 25 . . . cord-010119-t1x9gknd 3044 1 Effect effect NN cord-010119-t1x9gknd 3044 2 of of IN cord-010119-t1x9gknd 3044 3 Double double JJ cord-010119-t1x9gknd 3044 4 - - HYPH cord-010119-t1x9gknd 3044 5 End end NN cord-010119-t1x9gknd 3044 6 Cryopreservation Cryopreservation NNP cord-010119-t1x9gknd 3044 7 on on IN cord-010119-t1x9gknd 3044 8 Gene Gene NNP cord-010119-t1x9gknd 3044 9 - - HYPH cord-010119-t1x9gknd 3044 10 Transduced Transduced NNP cord-010119-t1x9gknd 3044 11 Human Human NNP cord-010119-t1x9gknd 3044 12 Hematopoietic Hematopoietic NNP cord-010119-t1x9gknd 3044 13 Stem Stem NNP cord-010119-t1x9gknd 3044 14 and and CC cord-010119-t1x9gknd 3044 15 Progenitor Progenitor NNP cord-010119-t1x9gknd 3044 16 Cells Cells NNPS cord-010119-t1x9gknd 3044 17 Sandeep Sandeep NNP cord-010119-t1x9gknd 3044 18 K K NNP cord-010119-t1x9gknd 3044 19 Srivastava Srivastava NNP cord-010119-t1x9gknd 3044 20 * * NFP cord-010119-t1x9gknd 3044 21 , , , cord-010119-t1x9gknd 3044 22 Jiaqiang Jiaqiang NNP cord-010119-t1x9gknd 3044 23 Ren Ren NNP cord-010119-t1x9gknd 3044 24 , , , cord-010119-t1x9gknd 3044 25 Steven Steven NNP cord-010119-t1x9gknd 3044 26 Highfill Highfill NNP cord-010119-t1x9gknd 3044 27 , , , cord-010119-t1x9gknd 3044 28 Narda Narda NNP cord-010119-t1x9gknd 3044 29 Theobald Theobald NNP cord-010119-t1x9gknd 3044 30 , , , cord-010119-t1x9gknd 3044 31 Suksee Suksee NNP cord-010119-t1x9gknd 3044 32 DeRavin DeRavin NNP cord-010119-t1x9gknd 3044 33 , , , cord-010119-t1x9gknd 3044 34 Andre Andre NNP cord-010119-t1x9gknd 3044 35 Larochelle Larochelle NNP cord-010119-t1x9gknd 3044 36 , , , cord-010119-t1x9gknd 3044 37 David David NNP cord-010119-t1x9gknd 3044 38 F F NNP cord-010119-t1x9gknd 3044 39 Stroncek Stroncek NNP cord-010119-t1x9gknd 3044 40 and and CC cord-010119-t1x9gknd 3044 41 Sandhya Sandhya NNP cord-010119-t1x9gknd 3044 42 R R NNP cord-010119-t1x9gknd 3044 43 Panch Panch NNP cord-010119-t1x9gknd 3044 44 . . . cord-010119-t1x9gknd 3045 1 National National NNP cord-010119-t1x9gknd 3045 2 Institutes Institutes NNPS cord-010119-t1x9gknd 3045 3 of of IN cord-010119-t1x9gknd 3045 4 Health Health NNP cord-010119-t1x9gknd 3045 5 Background Background NNP cord-010119-t1x9gknd 3045 6 / / SYM cord-010119-t1x9gknd 3045 7 Case Case NNP cord-010119-t1x9gknd 3045 8 Studies Studies NNPS cord-010119-t1x9gknd 3045 9 : : : cord-010119-t1x9gknd 3046 1 Current current JJ cord-010119-t1x9gknd 3046 2 early early JJ cord-010119-t1x9gknd 3046 3 - - HYPH cord-010119-t1x9gknd 3046 4 phase phase NN cord-010119-t1x9gknd 3046 5 clinical clinical JJ cord-010119-t1x9gknd 3046 6 gene gene NN cord-010119-t1x9gknd 3046 7 therapy therapy NN cord-010119-t1x9gknd 3046 8 trials trial NNS cord-010119-t1x9gknd 3046 9 use use VBP cord-010119-t1x9gknd 3046 10 freshly freshly RB cord-010119-t1x9gknd 3046 11 collected collect VBN cord-010119-t1x9gknd 3046 12 or or CC cord-010119-t1x9gknd 3046 13 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3046 14 CD341 cd341 NN cord-010119-t1x9gknd 3046 15 cells cell NNS cord-010119-t1x9gknd 3046 16 as as IN cord-010119-t1x9gknd 3046 17 the the DT cord-010119-t1x9gknd 3046 18 starting start VBG cord-010119-t1x9gknd 3046 19 fraction fraction NN cord-010119-t1x9gknd 3046 20 prior prior RB cord-010119-t1x9gknd 3046 21 to to IN cord-010119-t1x9gknd 3046 22 gene gene NN cord-010119-t1x9gknd 3046 23 manipulation manipulation NN cord-010119-t1x9gknd 3046 24 . . . cord-010119-t1x9gknd 3047 1 Following follow VBG cord-010119-t1x9gknd 3047 2 gene gene NN cord-010119-t1x9gknd 3047 3 - - HYPH cord-010119-t1x9gknd 3047 4 transduction transduction NN cord-010119-t1x9gknd 3047 5 and and CC cord-010119-t1x9gknd 3047 6 culture culture NN cord-010119-t1x9gknd 3047 7 , , , cord-010119-t1x9gknd 3047 8 the the DT cord-010119-t1x9gknd 3047 9 end end NN cord-010119-t1x9gknd 3047 10 product product NN cord-010119-t1x9gknd 3047 11 is be VBZ cord-010119-t1x9gknd 3047 12 infused infuse VBN cord-010119-t1x9gknd 3047 13 fresh fresh JJ cord-010119-t1x9gknd 3047 14 into into IN cord-010119-t1x9gknd 3047 15 recipients recipient NNS cord-010119-t1x9gknd 3047 16 . . . cord-010119-t1x9gknd 3048 1 For for IN cord-010119-t1x9gknd 3048 2 wider wide JJR cord-010119-t1x9gknd 3048 3 applicability applicability NN cord-010119-t1x9gknd 3048 4 and and CC cord-010119-t1x9gknd 3048 5 scale scale NN cord-010119-t1x9gknd 3048 6 - - HYPH cord-010119-t1x9gknd 3048 7 up up NN cord-010119-t1x9gknd 3048 8 , , , cord-010119-t1x9gknd 3048 9 gene gene NN cord-010119-t1x9gknd 3048 10 therapy therapy NN cord-010119-t1x9gknd 3048 11 manufacturing manufacturing NN cord-010119-t1x9gknd 3048 12 protocols protocol NNS cord-010119-t1x9gknd 3048 13 would would MD cord-010119-t1x9gknd 3048 14 benefit benefit VB cord-010119-t1x9gknd 3048 15 from from IN cord-010119-t1x9gknd 3048 16 double double JJ cord-010119-t1x9gknd 3048 17 - - HYPH cord-010119-t1x9gknd 3048 18 end end NN cord-010119-t1x9gknd 3048 19 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3048 20 ( ( -LRB- cord-010119-t1x9gknd 3048 21 DEC DEC NNP cord-010119-t1x9gknd 3048 22 ) ) -RRB- cord-010119-t1x9gknd 3048 23 of of IN cord-010119-t1x9gknd 3048 24 CD341 cd341 NN cord-010119-t1x9gknd 3048 25 cells cell NNS cord-010119-t1x9gknd 3048 26 during during IN cord-010119-t1x9gknd 3048 27 manufacture manufacture NN cord-010119-t1x9gknd 3048 28 ( ( -LRB- cord-010119-t1x9gknd 3048 29 i.e. i.e. FW cord-010119-t1x9gknd 3048 30 immediately immediately RB cord-010119-t1x9gknd 3048 31 post post NN cord-010119-t1x9gknd 3048 32 - - NN cord-010119-t1x9gknd 3048 33 collection collection JJ cord-010119-t1x9gknd 3048 34 and and CC cord-010119-t1x9gknd 3048 35 again again RB cord-010119-t1x9gknd 3048 36 , , , cord-010119-t1x9gknd 3048 37 post post JJ cord-010119-t1x9gknd 3048 38 - - JJ cord-010119-t1x9gknd 3048 39 gene gene JJ cord-010119-t1x9gknd 3048 40 modification modification NN cord-010119-t1x9gknd 3048 41 ) ) -RRB- cord-010119-t1x9gknd 3048 42 . . . cord-010119-t1x9gknd 3049 1 DEC DEC NNP cord-010119-t1x9gknd 3049 2 helps help VBZ cord-010119-t1x9gknd 3049 3 delink delink VB cord-010119-t1x9gknd 3049 4 patients patient NNS cord-010119-t1x9gknd 3049 5 ' ' POS cord-010119-t1x9gknd 3049 6 preparative preparative JJ cord-010119-t1x9gknd 3049 7 conditioning conditioning NN cord-010119-t1x9gknd 3049 8 phase phase NN cord-010119-t1x9gknd 3049 9 from from IN cord-010119-t1x9gknd 3049 10 cell cell NN cord-010119-t1x9gknd 3049 11 manufacture manufacture NN cord-010119-t1x9gknd 3049 12 , , , cord-010119-t1x9gknd 3049 13 eases ease VBZ cord-010119-t1x9gknd 3049 14 logistics logistic NNS cord-010119-t1x9gknd 3049 15 of of IN cord-010119-t1x9gknd 3049 16 inter inter JJ cord-010119-t1x9gknd 3049 17 - - JJ cord-010119-t1x9gknd 3049 18 facility facility JJ cord-010119-t1x9gknd 3049 19 cell cell NN cord-010119-t1x9gknd 3049 20 transportation transportation NN cord-010119-t1x9gknd 3049 21 , , , cord-010119-t1x9gknd 3049 22 and and CC cord-010119-t1x9gknd 3049 23 ensures ensure VBZ cord-010119-t1x9gknd 3049 24 fulfillment fulfillment NN cord-010119-t1x9gknd 3049 25 of of IN cord-010119-t1x9gknd 3049 26 regulatory regulatory JJ cord-010119-t1x9gknd 3049 27 product product NN cord-010119-t1x9gknd 3049 28 release release NN cord-010119-t1x9gknd 3049 29 criteria criterion NNS cord-010119-t1x9gknd 3049 30 before before IN cord-010119-t1x9gknd 3049 31 infusion infusion NN cord-010119-t1x9gknd 3049 32 . . . cord-010119-t1x9gknd 3050 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3050 2 objective objective NN cord-010119-t1x9gknd 3050 3 was be VBD cord-010119-t1x9gknd 3050 4 to to TO cord-010119-t1x9gknd 3050 5 study study VB cord-010119-t1x9gknd 3050 6 the the DT cord-010119-t1x9gknd 3050 7 effects effect NNS cord-010119-t1x9gknd 3050 8 of of IN cord-010119-t1x9gknd 3050 9 DEC DEC NNP cord-010119-t1x9gknd 3050 10 on on IN cord-010119-t1x9gknd 3050 11 gene gene NN cord-010119-t1x9gknd 3050 12 transduced transduce VBN cord-010119-t1x9gknd 3050 13 mobilized mobilize VBD cord-010119-t1x9gknd 3050 14 peripheral peripheral JJ cord-010119-t1x9gknd 3050 15 blood blood NN cord-010119-t1x9gknd 3050 16 ( ( -LRB- cord-010119-t1x9gknd 3050 17 MPB MPB NNP cord-010119-t1x9gknd 3050 18 ) ) -RRB- cord-010119-t1x9gknd 3050 19 CD341 cd341 NN cord-010119-t1x9gknd 3050 20 cells cell NNS cord-010119-t1x9gknd 3050 21 . . . cord-010119-t1x9gknd 3051 1 Study Study NNP cord-010119-t1x9gknd 3051 2 Design Design NNP cord-010119-t1x9gknd 3051 3 / / SYM cord-010119-t1x9gknd 3051 4 Method method NN cord-010119-t1x9gknd 3051 5 : : : cord-010119-t1x9gknd 3051 6 Cryopreserved Cryopreserved NNP cord-010119-t1x9gknd 3051 7 CD341 cd341 NN cord-010119-t1x9gknd 3051 8 cells cell NNS cord-010119-t1x9gknd 3051 9 from from IN cord-010119-t1x9gknd 3051 10 2 2 CD cord-010119-t1x9gknd 3051 11 healthy healthy JJ cord-010119-t1x9gknd 3051 12 adult adult NN cord-010119-t1x9gknd 3051 13 donors donor NNS cord-010119-t1x9gknd 3051 14 were be VBD cord-010119-t1x9gknd 3051 15 thawed thaw VBN cord-010119-t1x9gknd 3051 16 and and CC cord-010119-t1x9gknd 3051 17 transduced transduce VBN cord-010119-t1x9gknd 3051 18 ( ( -LRB- cord-010119-t1x9gknd 3051 19 TR TR NNP cord-010119-t1x9gknd 3051 20 ) ) -RRB- cord-010119-t1x9gknd 3051 21 in in IN cord-010119-t1x9gknd 3051 22 RetroNectin RetroNectin NNP cord-010119-t1x9gknd 3051 23 coated coat VBD cord-010119-t1x9gknd 3051 24 tissue tissue NN cord-010119-t1x9gknd 3051 25 culture culture NN cord-010119-t1x9gknd 3051 26 bags bag NNS cord-010119-t1x9gknd 3051 27 with with IN cord-010119-t1x9gknd 3051 28 an an DT cord-010119-t1x9gknd 3051 29 EF1-alpha ef1-alpha NN cord-010119-t1x9gknd 3051 30 - - HYPH cord-010119-t1x9gknd 3051 31 YFP yfp NN cord-010119-t1x9gknd 3051 32 lentivirus lentivirus NN cord-010119-t1x9gknd 3051 33 ( ( -LRB- cord-010119-t1x9gknd 3051 34 2.5 2.5 CD cord-010119-t1x9gknd 3051 35 % % NN cord-010119-t1x9gknd 3051 36 concentration concentration NN cord-010119-t1x9gknd 3051 37 ) ) -RRB- cord-010119-t1x9gknd 3051 38 and and CC cord-010119-t1x9gknd 3051 39 media medium NNS cord-010119-t1x9gknd 3051 40 ( ( -LRB- cord-010119-t1x9gknd 3051 41 X x NN cord-010119-t1x9gknd 3051 42 - - HYPH cord-010119-t1x9gknd 3051 43 VIVO-10 vivo-10 JJ cord-010119-t1x9gknd 3051 44 , , , cord-010119-t1x9gknd 3051 45 human human JJ cord-010119-t1x9gknd 3051 46 serum serum NN cord-010119-t1x9gknd 3051 47 albumin(HSA albumin(hsa NN cord-010119-t1x9gknd 3051 48 ) ) -RRB- cord-010119-t1x9gknd 3052 1 , , , cord-010119-t1x9gknd 3052 2 100 100 CD cord-010119-t1x9gknd 3052 3 ng ng NN cord-010119-t1x9gknd 3052 4 / / SYM cord-010119-t1x9gknd 3052 5 mL ml XX cord-010119-t1x9gknd 3052 6 each each DT cord-010119-t1x9gknd 3052 7 of of IN cord-010119-t1x9gknd 3052 8 cytokines cytokine NNS cord-010119-t1x9gknd 3052 9 ( ( -LRB- cord-010119-t1x9gknd 3052 10 SCF SCF NNP cord-010119-t1x9gknd 3052 11 , , , cord-010119-t1x9gknd 3052 12 TPO TPO NNP cord-010119-t1x9gknd 3052 13 and and CC cord-010119-t1x9gknd 3052 14 FLT3-L FLT3-L NNP cord-010119-t1x9gknd 3052 15 ) ) -RRB- cord-010119-t1x9gknd 3053 1 over over IN cord-010119-t1x9gknd 3053 2 2 2 CD cord-010119-t1x9gknd 3053 3 days day NNS cord-010119-t1x9gknd 3053 4 . . . cord-010119-t1x9gknd 3054 1 Untransduced Untransduced NNP cord-010119-t1x9gknd 3054 2 ( ( -LRB- cord-010119-t1x9gknd 3054 3 UTR UTR NNP cord-010119-t1x9gknd 3054 4 ) ) -RRB- cord-010119-t1x9gknd 3054 5 cells cell NNS cord-010119-t1x9gknd 3054 6 were be VBD cord-010119-t1x9gknd 3054 7 cultured cultured JJ cord-010119-t1x9gknd 3054 8 as as IN cord-010119-t1x9gknd 3054 9 controls control NNS cord-010119-t1x9gknd 3054 10 . . . cord-010119-t1x9gknd 3055 1 TR TR NNP cord-010119-t1x9gknd 3055 2 and and CC cord-010119-t1x9gknd 3055 3 UTR UTR NNP cord-010119-t1x9gknd 3055 4 fractions fraction NNS cord-010119-t1x9gknd 3055 5 were be VBD cord-010119-t1x9gknd 3055 6 re re VBN cord-010119-t1x9gknd 3055 7 - - VBN cord-010119-t1x9gknd 3055 8 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 3055 9 . . . cord-010119-t1x9gknd 3056 1 A a DT cord-010119-t1x9gknd 3056 2 standard standard JJ cord-010119-t1x9gknd 3056 3 freeze freeze NN cord-010119-t1x9gknd 3056 4 - - HYPH cord-010119-t1x9gknd 3056 5 mix mix NN cord-010119-t1x9gknd 3056 6 of of IN cord-010119-t1x9gknd 3056 7 5 5 CD cord-010119-t1x9gknd 3056 8 % % NN cord-010119-t1x9gknd 3056 9 DMSO DMSO NNP cord-010119-t1x9gknd 3056 10 , , , cord-010119-t1x9gknd 3056 11 6 6 CD cord-010119-t1x9gknd 3056 12 % % NN cord-010119-t1x9gknd 3056 13 Pentastarch Pentastarch NNP cord-010119-t1x9gknd 3056 14 , , , cord-010119-t1x9gknd 3056 15 HSA HSA NNP cord-010119-t1x9gknd 3056 16 , , , cord-010119-t1x9gknd 3057 1 plasma plasma NN cord-010119-t1x9gknd 3057 2 - - : cord-010119-t1x9gknd 3057 3 Lyte Lyte NNP cord-010119-t1x9gknd 3057 4 A A NNP cord-010119-t1x9gknd 3057 5 was be VBD cord-010119-t1x9gknd 3057 6 used use VBN cord-010119-t1x9gknd 3057 7 for for IN cord-010119-t1x9gknd 3057 8 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3057 9 . . . cord-010119-t1x9gknd 3058 1 Viability viability NN cord-010119-t1x9gknd 3058 2 , , , cord-010119-t1x9gknd 3058 3 Hematopoietic Hematopoietic NNP cord-010119-t1x9gknd 3058 4 stem stem NN cord-010119-t1x9gknd 3058 5 cell cell NN cord-010119-t1x9gknd 3058 6 ( ( -LRB- cord-010119-t1x9gknd 3058 7 HSC HSC NNP cord-010119-t1x9gknd 3058 8 ) ) -RRB- cord-010119-t1x9gknd 3058 9 ( ( -LRB- cord-010119-t1x9gknd 3058 10 CD34 CD34 NNP cord-010119-t1x9gknd 3058 11 1 1 CD cord-010119-t1x9gknd 3058 12 CD38 CD38 NNP cord-010119-t1x9gknd 3059 1 -CD45RA -cd45ra NN cord-010119-t1x9gknd 3060 1 -CD90 -CD90 VBZ cord-010119-t1x9gknd 3060 2 1 1 CD cord-010119-t1x9gknd 3060 3 CD49f CD49f NNP cord-010119-t1x9gknd 3060 4 1 1 CD cord-010119-t1x9gknd 3060 5 cells cell NNS cord-010119-t1x9gknd 3060 6 ) ) -RRB- cord-010119-t1x9gknd 3060 7 phenotyping phenotyping NN cord-010119-t1x9gknd 3060 8 and and CC cord-010119-t1x9gknd 3060 9 CFU CFU NNP cord-010119-t1x9gknd 3060 10 assays assay NNS cord-010119-t1x9gknd 3060 11 were be VBD cord-010119-t1x9gknd 3060 12 done do VBN cord-010119-t1x9gknd 3060 13 following follow VBG cord-010119-t1x9gknd 3060 14 first first JJ cord-010119-t1x9gknd 3060 15 thaw thaw NN cord-010119-t1x9gknd 3060 16 ( ( -LRB- cord-010119-t1x9gknd 3060 17 PT1 PT1 NNP cord-010119-t1x9gknd 3060 18 ) ) -RRB- cord-010119-t1x9gknd 3060 19 , , , cord-010119-t1x9gknd 3060 20 post post NN cord-010119-t1x9gknd 3060 21 - - NN cord-010119-t1x9gknd 3060 22 transduction transduction JJ cord-010119-t1x9gknd 3060 23 ( ( -LRB- cord-010119-t1x9gknd 3060 24 PTxn ptxn CD cord-010119-t1x9gknd 3060 25 ) ) -RRB- cord-010119-t1x9gknd 3060 26 and and CC cord-010119-t1x9gknd 3060 27 second second JJ cord-010119-t1x9gknd 3060 28 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3060 29 - - HYPH cord-010119-t1x9gknd 3060 30 thaw thaw NN cord-010119-t1x9gknd 3060 31 ( ( -LRB- cord-010119-t1x9gknd 3060 32 PT2 pt2 NN cord-010119-t1x9gknd 3060 33 ) ) -RRB- cord-010119-t1x9gknd 3060 34 . . . cord-010119-t1x9gknd 3061 1 Results/ Results/ . cord-010119-t1x9gknd 3062 1 Finding finding NN cord-010119-t1x9gknd 3062 2 : : : cord-010119-t1x9gknd 3063 1 TNC TNC NNP cord-010119-t1x9gknd 3063 2 recovery recovery NN cord-010119-t1x9gknd 3063 3 decreased decrease VBD cord-010119-t1x9gknd 3063 4 gradually gradually RB cord-010119-t1x9gknd 3063 5 in in IN cord-010119-t1x9gknd 3063 6 the the DT cord-010119-t1x9gknd 3063 7 donor donor NN cord-010119-t1x9gknd 3063 8 samples sample NNS cord-010119-t1x9gknd 3063 9 at at IN cord-010119-t1x9gknd 3063 10 each each DT cord-010119-t1x9gknd 3063 11 step step NN cord-010119-t1x9gknd 3063 12 . . . cord-010119-t1x9gknd 3064 1 Transduction transduction NN cord-010119-t1x9gknd 3064 2 efficiency efficiency NN cord-010119-t1x9gknd 3064 3 , , , cord-010119-t1x9gknd 3064 4 CD34 CD34 NNP cord-010119-t1x9gknd 3064 5 % % NN cord-010119-t1x9gknd 3064 6 , , , cord-010119-t1x9gknd 3064 7 CFUs CFUs NNP cord-010119-t1x9gknd 3064 8 were be VBD cord-010119-t1x9gknd 3064 9 similar similar JJ cord-010119-t1x9gknd 3064 10 before before IN cord-010119-t1x9gknd 3064 11 and and CC cord-010119-t1x9gknd 3064 12 after after IN cord-010119-t1x9gknd 3064 13 PT2 PT2 NNP cord-010119-t1x9gknd 3064 14 . . . cord-010119-t1x9gknd 3065 1 HSCs hsc NNS cord-010119-t1x9gknd 3065 2 ranged range VBD cord-010119-t1x9gknd 3065 3 from from IN cord-010119-t1x9gknd 3065 4 824 824 CD cord-010119-t1x9gknd 3065 5 to to IN cord-010119-t1x9gknd 3065 6 1655 1655 CD cord-010119-t1x9gknd 3065 7 cells/10 cells/10 NNP cord-010119-t1x9gknd 3065 8 6 6 CD cord-010119-t1x9gknd 3065 9 CD341 cd341 NN cord-010119-t1x9gknd 3065 10 cells cell NNS cord-010119-t1x9gknd 3065 11 in in IN cord-010119-t1x9gknd 3065 12 the the DT cord-010119-t1x9gknd 3065 13 PT2-TR pt2-tr JJ cord-010119-t1x9gknd 3065 14 arm arm NN cord-010119-t1x9gknd 3065 15 compared compare VBN cord-010119-t1x9gknd 3065 16 to to IN cord-010119-t1x9gknd 3065 17 a a DT cord-010119-t1x9gknd 3065 18 range range NN cord-010119-t1x9gknd 3065 19 of of IN cord-010119-t1x9gknd 3065 20 286 286 CD cord-010119-t1x9gknd 3065 21 to to IN cord-010119-t1x9gknd 3065 22 1416 1416 CD cord-010119-t1x9gknd 3065 23 /10 /10 . cord-010119-t1x9gknd 3066 1 6 6 CD cord-010119-t1x9gknd 3067 1 CD341 cd341 NN cord-010119-t1x9gknd 3067 2 cells cell NNS cord-010119-t1x9gknd 3067 3 after after IN cord-010119-t1x9gknd 3067 4 PT1 PT1 NNP cord-010119-t1x9gknd 3067 5 . . . cord-010119-t1x9gknd 3068 1 Viability viability NN cord-010119-t1x9gknd 3068 2 , , , cord-010119-t1x9gknd 3068 3 % % NN cord-010119-t1x9gknd 3068 4 CD341 cd341 NN cord-010119-t1x9gknd 3068 5 and and CC cord-010119-t1x9gknd 3068 6 CFUs cfus NN cord-010119-t1x9gknd 3068 7 were be VBD cord-010119-t1x9gknd 3068 8 lower low JJR cord-010119-t1x9gknd 3068 9 in in IN cord-010119-t1x9gknd 3068 10 the the DT cord-010119-t1x9gknd 3068 11 TR tr NN cord-010119-t1x9gknd 3068 12 compared compare VBN cord-010119-t1x9gknd 3068 13 to to IN cord-010119-t1x9gknd 3068 14 the the DT cord-010119-t1x9gknd 3068 15 UTR UTR NNP cord-010119-t1x9gknd 3068 16 arm arm NN cord-010119-t1x9gknd 3068 17 . . . cord-010119-t1x9gknd 3069 1 This this DT cord-010119-t1x9gknd 3069 2 difference difference NN cord-010119-t1x9gknd 3069 3 was be VBD cord-010119-t1x9gknd 3069 4 not not RB cord-010119-t1x9gknd 3069 5 altered alter VBN cord-010119-t1x9gknd 3069 6 after after IN cord-010119-t1x9gknd 3069 7 PT2 PT2 NNP cord-010119-t1x9gknd 3069 8 ( ( -LRB- cord-010119-t1x9gknd 3069 9 Table table NN cord-010119-t1x9gknd 3069 10 ) ) -RRB- cord-010119-t1x9gknd 3069 11 . . . cord-010119-t1x9gknd 3070 1 Conclusion conclusion NN cord-010119-t1x9gknd 3070 2 : : : cord-010119-t1x9gknd 3070 3 DEC DEC NNP cord-010119-t1x9gknd 3070 4 of of IN cord-010119-t1x9gknd 3070 5 MPB MPB NNP cord-010119-t1x9gknd 3070 6 human human JJ cord-010119-t1x9gknd 3070 7 CD341 cd341 NN cord-010119-t1x9gknd 3070 8 cells cell NNS cord-010119-t1x9gknd 3070 9 decreases decrease VBZ cord-010119-t1x9gknd 3070 10 TNC TNC NNP cord-010119-t1x9gknd 3070 11 recovery recovery NN cord-010119-t1x9gknd 3070 12 , , , cord-010119-t1x9gknd 3070 13 but but CC cord-010119-t1x9gknd 3070 14 has have VBZ cord-010119-t1x9gknd 3070 15 minimal minimal JJ cord-010119-t1x9gknd 3070 16 effects effect NNS cord-010119-t1x9gknd 3070 17 on on IN cord-010119-t1x9gknd 3070 18 CD341 cd341 NN cord-010119-t1x9gknd 3070 19 cell cell NN cord-010119-t1x9gknd 3070 20 phenotype phenotype NN cord-010119-t1x9gknd 3070 21 , , , cord-010119-t1x9gknd 3070 22 transduction transduction NN cord-010119-t1x9gknd 3070 23 efficiency efficiency NN cord-010119-t1x9gknd 3070 24 and and CC cord-010119-t1x9gknd 3070 25 cell cell NN cord-010119-t1x9gknd 3070 26 function function NN cord-010119-t1x9gknd 3070 27 . . . cord-010119-t1x9gknd 3071 1 HSC HSC NNP cord-010119-t1x9gknd 3071 2 numbers number NNS cord-010119-t1x9gknd 3071 3 were be VBD cord-010119-t1x9gknd 3071 4 within within IN cord-010119-t1x9gknd 3071 5 acceptable acceptable JJ cord-010119-t1x9gknd 3071 6 range range NN cord-010119-t1x9gknd 3071 7 after after IN cord-010119-t1x9gknd 3071 8 recryopreservation recryopreservation NN cord-010119-t1x9gknd 3071 9 . . . cord-010119-t1x9gknd 3072 1 Lower low JJR cord-010119-t1x9gknd 3072 2 viability viability NN cord-010119-t1x9gknd 3072 3 and and CC cord-010119-t1x9gknd 3072 4 CD34 CD34 NNP cord-010119-t1x9gknd 3072 5 % % NN cord-010119-t1x9gknd 3072 6 in in IN cord-010119-t1x9gknd 3072 7 the the DT cord-010119-t1x9gknd 3072 8 TR tr NN cord-010119-t1x9gknd 3072 9 arm arm NN cord-010119-t1x9gknd 3073 1 compared compare VBN cord-010119-t1x9gknd 3073 2 to to IN cord-010119-t1x9gknd 3073 3 the the DT cord-010119-t1x9gknd 3073 4 UTR UTR NNP cord-010119-t1x9gknd 3073 5 arm arm NN cord-010119-t1x9gknd 3073 6 is be VBZ cord-010119-t1x9gknd 3073 7 likely likely JJ cord-010119-t1x9gknd 3073 8 due due IN cord-010119-t1x9gknd 3073 9 to to IN cord-010119-t1x9gknd 3073 10 vector vector NN cord-010119-t1x9gknd 3073 11 toxicity toxicity NN cord-010119-t1x9gknd 3073 12 . . . cord-010119-t1x9gknd 3074 1 This this DT cord-010119-t1x9gknd 3074 2 was be VBD cord-010119-t1x9gknd 3074 3 unaffected unaffected JJ cord-010119-t1x9gknd 3074 4 by by IN cord-010119-t1x9gknd 3074 5 recryopreservation recryopreservation NN cord-010119-t1x9gknd 3074 6 . . . cord-010119-t1x9gknd 3075 1 Additional additional JJ cord-010119-t1x9gknd 3075 2 studies study NNS cord-010119-t1x9gknd 3075 3 to to TO cord-010119-t1x9gknd 3075 4 assess assess VB cord-010119-t1x9gknd 3075 5 DEC DEC NNP cord-010119-t1x9gknd 3075 6 mediated mediate VBN cord-010119-t1x9gknd 3075 7 changes change NNS cord-010119-t1x9gknd 3075 8 on on IN cord-010119-t1x9gknd 3075 9 CD341 cd341 NN cord-010119-t1x9gknd 3075 10 cell cell NN cord-010119-t1x9gknd 3075 11 early early JJ cord-010119-t1x9gknd 3075 12 apoptotic apoptotic JJ cord-010119-t1x9gknd 3075 13 markers marker NNS cord-010119-t1x9gknd 3075 14 , , , cord-010119-t1x9gknd 3075 15 telomere telomere NN cord-010119-t1x9gknd 3075 16 lengths length NNS cord-010119-t1x9gknd 3075 17 , , , cord-010119-t1x9gknd 3075 18 gene gene NN cord-010119-t1x9gknd 3075 19 expression expression NN cord-010119-t1x9gknd 3075 20 and and CC cord-010119-t1x9gknd 3075 21 engraftment engraftment NN cord-010119-t1x9gknd 3075 22 potential potential NN cord-010119-t1x9gknd 3075 23 in in IN cord-010119-t1x9gknd 3075 24 NOD NOD NNP cord-010119-t1x9gknd 3075 25 / / SYM cord-010119-t1x9gknd 3075 26 SCID SCID NNP cord-010119-t1x9gknd 3075 27 mice mouse NNS cord-010119-t1x9gknd 3075 28 will will MD cord-010119-t1x9gknd 3075 29 inform inform VB cord-010119-t1x9gknd 3075 30 clinical clinical JJ cord-010119-t1x9gknd 3075 31 trials trial NNS cord-010119-t1x9gknd 3075 32 . . . cord-010119-t1x9gknd 3076 1 Background Background NNP cord-010119-t1x9gknd 3076 2 / / SYM cord-010119-t1x9gknd 3076 3 Case Case NNP cord-010119-t1x9gknd 3076 4 Studies Studies NNPS cord-010119-t1x9gknd 3076 5 : : : cord-010119-t1x9gknd 3076 6 Autologous autologous JJ cord-010119-t1x9gknd 3076 7 peripheral peripheral JJ cord-010119-t1x9gknd 3076 8 blood blood NN cord-010119-t1x9gknd 3076 9 stem stem NN cord-010119-t1x9gknd 3076 10 cell cell NN cord-010119-t1x9gknd 3076 11 ( ( -LRB- cord-010119-t1x9gknd 3076 12 PBSC PBSC NNP cord-010119-t1x9gknd 3076 13 ) ) -RRB- cord-010119-t1x9gknd 3076 14 transplantation transplantation NN cord-010119-t1x9gknd 3076 15 has have VBZ cord-010119-t1x9gknd 3076 16 been be VBN cord-010119-t1x9gknd 3076 17 used use VBN cord-010119-t1x9gknd 3076 18 as as IN cord-010119-t1x9gknd 3076 19 a a DT cord-010119-t1x9gknd 3076 20 powerful powerful JJ cord-010119-t1x9gknd 3076 21 resource resource NN cord-010119-t1x9gknd 3076 22 during during IN cord-010119-t1x9gknd 3076 23 the the DT cord-010119-t1x9gknd 3076 24 treatment treatment NN cord-010119-t1x9gknd 3076 25 of of IN cord-010119-t1x9gknd 3076 26 some some DT cord-010119-t1x9gknd 3076 27 hematological hematological JJ cord-010119-t1x9gknd 3076 28 malignancies malignancy NNS cord-010119-t1x9gknd 3076 29 . . . cord-010119-t1x9gknd 3077 1 Cryopreservation cryopreservation NN cord-010119-t1x9gknd 3077 2 of of IN cord-010119-t1x9gknd 3077 3 these these DT cord-010119-t1x9gknd 3077 4 cells cell NNS cord-010119-t1x9gknd 3077 5 is be VBZ cord-010119-t1x9gknd 3077 6 routinely routinely RB cord-010119-t1x9gknd 3077 7 performed perform VBN cord-010119-t1x9gknd 3077 8 to to TO cord-010119-t1x9gknd 3077 9 allow allow VB cord-010119-t1x9gknd 3077 10 for for IN cord-010119-t1x9gknd 3077 11 patient patient JJ cord-010119-t1x9gknd 3077 12 adequate adequate JJ cord-010119-t1x9gknd 3077 13 conditioning conditioning NN cord-010119-t1x9gknd 3077 14 and and CC cord-010119-t1x9gknd 3077 15 chemotherapy chemotherapy NN cord-010119-t1x9gknd 3077 16 . . . cord-010119-t1x9gknd 3078 1 In in IN cord-010119-t1x9gknd 3078 2 some some DT cord-010119-t1x9gknd 3078 3 cases case NNS cord-010119-t1x9gknd 3078 4 , , , cord-010119-t1x9gknd 3078 5 PBSC PBSC NNP cord-010119-t1x9gknd 3078 6 are be VBP cord-010119-t1x9gknd 3078 7 harvested harvest VBN cord-010119-t1x9gknd 3078 8 as as IN cord-010119-t1x9gknd 3078 9 a a DT cord-010119-t1x9gknd 3078 10 backup backup JJ cord-010119-t1x9gknd 3078 11 option option NN cord-010119-t1x9gknd 3078 12 and and CC cord-010119-t1x9gknd 3078 13 remain remain VB cord-010119-t1x9gknd 3078 14 stored store VBN cord-010119-t1x9gknd 3078 15 for for IN cord-010119-t1x9gknd 3078 16 several several JJ cord-010119-t1x9gknd 3078 17 years year NNS cord-010119-t1x9gknd 3078 18 , , , cord-010119-t1x9gknd 3078 19 although although IN cord-010119-t1x9gknd 3078 20 effect effect NN cord-010119-t1x9gknd 3078 21 of of IN cord-010119-t1x9gknd 3078 22 storage storage NN cord-010119-t1x9gknd 3078 23 lesion lesion NN cord-010119-t1x9gknd 3078 24 in in IN cord-010119-t1x9gknd 3078 25 this this DT cord-010119-t1x9gknd 3078 26 product product NN cord-010119-t1x9gknd 3078 27 is be VBZ cord-010119-t1x9gknd 3078 28 still still RB cord-010119-t1x9gknd 3078 29 controversial controversial JJ cord-010119-t1x9gknd 3078 30 . . . cord-010119-t1x9gknd 3079 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3079 2 work work NN cord-010119-t1x9gknd 3079 3 presents present VBZ cord-010119-t1x9gknd 3079 4 retrospective retrospective JJ cord-010119-t1x9gknd 3079 5 data datum NNS cord-010119-t1x9gknd 3079 6 on on IN cord-010119-t1x9gknd 3079 7 PBSC PBSC NNP cord-010119-t1x9gknd 3079 8 infusion infusion NN cord-010119-t1x9gknd 3079 9 after after IN cord-010119-t1x9gknd 3079 10 long long JJ cord-010119-t1x9gknd 3079 11 - - HYPH cord-010119-t1x9gknd 3079 12 term term NN cord-010119-t1x9gknd 3079 13 storage storage NN cord-010119-t1x9gknd 3079 14 . . . cord-010119-t1x9gknd 3080 1 Study Study NNP cord-010119-t1x9gknd 3080 2 Design Design NNP cord-010119-t1x9gknd 3080 3 / / SYM cord-010119-t1x9gknd 3080 4 Method method NN cord-010119-t1x9gknd 3080 5 : : : cord-010119-t1x9gknd 3081 1 All all DT cord-010119-t1x9gknd 3081 2 products product NNS cord-010119-t1x9gknd 3081 3 were be VBD cord-010119-t1x9gknd 3081 4 harvested harvest VBN cord-010119-t1x9gknd 3081 5 after after IN cord-010119-t1x9gknd 3081 6 patient patient JJ cord-010119-t1x9gknd 3081 7 mobilization mobilization NN cord-010119-t1x9gknd 3081 8 with with IN cord-010119-t1x9gknd 3081 9 G G NNP cord-010119-t1x9gknd 3081 10 - - HYPH cord-010119-t1x9gknd 3081 11 CSF CSF NNP cord-010119-t1x9gknd 3081 12 by by IN cord-010119-t1x9gknd 3081 13 apheresis apheresis NN cord-010119-t1x9gknd 3081 14 with with IN cord-010119-t1x9gknd 3081 15 COBE COBE NNP cord-010119-t1x9gknd 3081 16 Spectra Spectra NNP cord-010119-t1x9gknd 3081 17 V V NNP cord-010119-t1x9gknd 3081 18 R r NN cord-010119-t1x9gknd 3081 19 . . . cord-010119-t1x9gknd 3082 1 Flow flow NN cord-010119-t1x9gknd 3082 2 cytometry cytometry NN cord-010119-t1x9gknd 3082 3 analysis analysis NN cord-010119-t1x9gknd 3082 4 of of IN cord-010119-t1x9gknd 3082 5 CD341 cd341 NN cord-010119-t1x9gknd 3082 6 cells cell NNS cord-010119-t1x9gknd 3082 7 was be VBD cord-010119-t1x9gknd 3082 8 performed perform VBN cord-010119-t1x9gknd 3082 9 prior prior RB cord-010119-t1x9gknd 3082 10 to to IN cord-010119-t1x9gknd 3082 11 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3082 12 . . . cord-010119-t1x9gknd 3083 1 The the DT cord-010119-t1x9gknd 3083 2 cryoprotective cryoprotective JJ cord-010119-t1x9gknd 3083 3 solution solution NN cord-010119-t1x9gknd 3083 4 was be VBD cord-010119-t1x9gknd 3083 5 freshly freshly RB cord-010119-t1x9gknd 3083 6 prepared prepare VBN cord-010119-t1x9gknd 3083 7 by by IN cord-010119-t1x9gknd 3083 8 addition addition NN cord-010119-t1x9gknd 3083 9 of of IN cord-010119-t1x9gknd 3083 10 20 20 CD cord-010119-t1x9gknd 3083 11 % % NN cord-010119-t1x9gknd 3083 12 hydroxyethyl hydroxyethyl NN cord-010119-t1x9gknd 3083 13 starch starch NN cord-010119-t1x9gknd 3083 14 , , , cord-010119-t1x9gknd 3083 15 18 18 CD cord-010119-t1x9gknd 3083 16 % % NN cord-010119-t1x9gknd 3083 17 human human JJ cord-010119-t1x9gknd 3083 18 serum serum NN cord-010119-t1x9gknd 3083 19 albumin albumin NN cord-010119-t1x9gknd 3083 20 and and CC cord-010119-t1x9gknd 3083 21 10 10 CD cord-010119-t1x9gknd 3083 22 % % NN cord-010119-t1x9gknd 3083 23 DMSO DMSO NNP cord-010119-t1x9gknd 3083 24 at at IN cord-010119-t1x9gknd 3083 25 final final JJ cord-010119-t1x9gknd 3083 26 concentration concentration NN cord-010119-t1x9gknd 3083 27 . . . cord-010119-t1x9gknd 3084 1 PBSC PBSC NNS cord-010119-t1x9gknd 3084 2 were be VBD cord-010119-t1x9gknd 3084 3 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3084 4 by by IN cord-010119-t1x9gknd 3084 5 direct direct JJ cord-010119-t1x9gknd 3084 6 immersion immersion NN cord-010119-t1x9gknd 3084 7 on on IN cord-010119-t1x9gknd 3084 8 -808C -808C HYPH cord-010119-t1x9gknd 3084 9 mechanical mechanical JJ cord-010119-t1x9gknd 3084 10 freezer freezer NN cord-010119-t1x9gknd 3084 11 ( ( -LRB- cord-010119-t1x9gknd 3084 12 dump dump NN cord-010119-t1x9gknd 3084 13 freeze freeze NN cord-010119-t1x9gknd 3084 14 ) ) -RRB- cord-010119-t1x9gknd 3084 15 and and CC cord-010119-t1x9gknd 3084 16 stored store VBN cord-010119-t1x9gknd 3084 17 until until IN cord-010119-t1x9gknd 3084 18 transplantation transplantation NN cord-010119-t1x9gknd 3084 19 . . . cord-010119-t1x9gknd 3085 1 Post post JJ cord-010119-t1x9gknd 3085 2 - - JJ cord-010119-t1x9gknd 3085 3 thaw thaw VB cord-010119-t1x9gknd 3085 4 viability viability NN cord-010119-t1x9gknd 3085 5 was be VBD cord-010119-t1x9gknd 3085 6 determined determine VBN cord-010119-t1x9gknd 3085 7 from from IN cord-010119-t1x9gknd 3085 8 stored store VBN cord-010119-t1x9gknd 3085 9 cryotube cryotube NN cord-010119-t1x9gknd 3085 10 samples sample NNS cord-010119-t1x9gknd 3085 11 by by IN cord-010119-t1x9gknd 3085 12 Trypan Trypan NNP cord-010119-t1x9gknd 3085 13 Blue Blue NNP cord-010119-t1x9gknd 3085 14 exclusion exclusion NN cord-010119-t1x9gknd 3085 15 minutes minute NNS cord-010119-t1x9gknd 3085 16 prior prior RB cord-010119-t1x9gknd 3085 17 to to IN cord-010119-t1x9gknd 3085 18 infusion infusion NN cord-010119-t1x9gknd 3085 19 . . . cord-010119-t1x9gknd 3086 1 Cells cell NNS cord-010119-t1x9gknd 3086 2 were be VBD cord-010119-t1x9gknd 3086 3 thawed thaw VBN cord-010119-t1x9gknd 3086 4 and and CC cord-010119-t1x9gknd 3086 5 infused infuse VBN cord-010119-t1x9gknd 3086 6 on on IN cord-010119-t1x9gknd 3086 7 bedside bedside NN cord-010119-t1x9gknd 3086 8 . . . cord-010119-t1x9gknd 3087 1 Engraftment Engraftment NNP cord-010119-t1x9gknd 3087 2 was be VBD cord-010119-t1x9gknd 3087 3 defined define VBN cord-010119-t1x9gknd 3087 4 as as IN cord-010119-t1x9gknd 3087 5 the the DT cord-010119-t1x9gknd 3087 6 first first JJ cord-010119-t1x9gknd 3087 7 day day NN cord-010119-t1x9gknd 3087 8 of of IN cord-010119-t1x9gknd 3087 9 03 03 CD cord-010119-t1x9gknd 3087 10 consecutive consecutive JJ cord-010119-t1x9gknd 3087 11 days day NNS cord-010119-t1x9gknd 3087 12 of of IN cord-010119-t1x9gknd 3087 13 neutrophil neutrophil NN cord-010119-t1x9gknd 3087 14 count count NN cord-010119-t1x9gknd 3087 15 > > XX cord-010119-t1x9gknd 3087 16 0.5 0.5 CD cord-010119-t1x9gknd 3087 17 x10 x10 CD cord-010119-t1x9gknd 3087 18 9 9 CD cord-010119-t1x9gknd 3087 19 /L /L . cord-010119-t1x9gknd 3087 20 and and CC cord-010119-t1x9gknd 3087 21 platelet platelet NN cord-010119-t1x9gknd 3087 22 count count NN cord-010119-t1x9gknd 3087 23 > > XX cord-010119-t1x9gknd 3087 24 20 20 CD cord-010119-t1x9gknd 3087 25 x10 x10 CD cord-010119-t1x9gknd 3087 26 9 9 CD cord-010119-t1x9gknd 3087 27 /L /L . cord-010119-t1x9gknd 3087 28 after after IN cord-010119-t1x9gknd 3087 29 07 07 CD cord-010119-t1x9gknd 3087 30 days day NNS cord-010119-t1x9gknd 3087 31 . . . cord-010119-t1x9gknd 3088 1 with with IN cord-010119-t1x9gknd 3088 2 G G NNP cord-010119-t1x9gknd 3088 3 - - HYPH cord-010119-t1x9gknd 3088 4 CSF CSF NNP cord-010119-t1x9gknd 3088 5 for for IN cord-010119-t1x9gknd 3088 6 four four CD cord-010119-t1x9gknd 3088 7 days day NNS cord-010119-t1x9gknd 3088 8 and and CC cord-010119-t1x9gknd 3088 9 patients patient NNS cord-010119-t1x9gknd 3088 10 with with IN cord-010119-t1x9gknd 3088 11 G G NNP cord-010119-t1x9gknd 3088 12 - - HYPH cord-010119-t1x9gknd 3088 13 CSF CSF NNP cord-010119-t1x9gknd 3088 14 for for IN cord-010119-t1x9gknd 3088 15 five five CD cord-010119-t1x9gknd 3088 16 days day NNS cord-010119-t1x9gknd 3088 17 with with IN cord-010119-t1x9gknd 3088 18 use use NN cord-010119-t1x9gknd 3088 19 of of IN cord-010119-t1x9gknd 3088 20 Mozobil Mozobil NNP cord-010119-t1x9gknd 3088 21 when when WRB cord-010119-t1x9gknd 3088 22 CD341 CD341 NNP cord-010119-t1x9gknd 3088 23 was be VBD cord-010119-t1x9gknd 3088 24 below below IN cord-010119-t1x9gknd 3088 25 10 10 CD cord-010119-t1x9gknd 3088 26 x x SYM cord-010119-t1x9gknd 3088 27 10 10 CD cord-010119-t1x9gknd 3088 28 6 6 CD cord-010119-t1x9gknd 3088 29 cells cell NNS cord-010119-t1x9gknd 3088 30 / / SYM cord-010119-t1x9gknd 3088 31 L l NN cord-010119-t1x9gknd 3088 32 on on IN cord-010119-t1x9gknd 3088 33 the the DT cord-010119-t1x9gknd 3088 34 fourth fourth JJ cord-010119-t1x9gknd 3088 35 day day NN cord-010119-t1x9gknd 3088 36 . . . cord-010119-t1x9gknd 3089 1 HPC HPC NNP cord-010119-t1x9gknd 3089 2 collection collection NN cord-010119-t1x9gknd 3089 3 was be VBD cord-010119-t1x9gknd 3089 4 performed perform VBN cord-010119-t1x9gknd 3089 5 on on IN cord-010119-t1x9gknd 3089 6 the the DT cord-010119-t1x9gknd 3089 7 fourth fourth JJ cord-010119-t1x9gknd 3089 8 day day NN cord-010119-t1x9gknd 3089 9 of of IN cord-010119-t1x9gknd 3089 10 mobilization mobilization NN cord-010119-t1x9gknd 3089 11 for for IN cord-010119-t1x9gknd 3089 12 healthy healthy JJ cord-010119-t1x9gknd 3089 13 donors donor NNS cord-010119-t1x9gknd 3089 14 and and CC cord-010119-t1x9gknd 3089 15 on on IN cord-010119-t1x9gknd 3089 16 the the DT cord-010119-t1x9gknd 3089 17 fifth fifth JJ cord-010119-t1x9gknd 3089 18 day day NN cord-010119-t1x9gknd 3089 19 for for IN cord-010119-t1x9gknd 3089 20 patients patient NNS cord-010119-t1x9gknd 3089 21 . . . cord-010119-t1x9gknd 3090 1 All all DT cord-010119-t1x9gknd 3090 2 procedures procedure NNS cord-010119-t1x9gknd 3090 3 were be VBD cord-010119-t1x9gknd 3090 4 realized realize VBN cord-010119-t1x9gknd 3090 5 based base VBN cord-010119-t1x9gknd 3090 6 on on IN cord-010119-t1x9gknd 3090 7 a a DT cord-010119-t1x9gknd 3090 8 prediction prediction NN cord-010119-t1x9gknd 3090 9 algorithm algorithm NN cord-010119-t1x9gknd 3090 10 using use VBG cord-010119-t1x9gknd 3090 11 pre pre JJ cord-010119-t1x9gknd 3090 12 - - NN cord-010119-t1x9gknd 3090 13 CD341 cd341 NN cord-010119-t1x9gknd 3090 14 on on IN cord-010119-t1x9gknd 3090 15 the the DT cord-010119-t1x9gknd 3090 16 day day NN cord-010119-t1x9gknd 3090 17 of of IN cord-010119-t1x9gknd 3090 18 the the DT cord-010119-t1x9gknd 3090 19 collection collection NN cord-010119-t1x9gknd 3090 20 and and CC cord-010119-t1x9gknd 3090 21 estimating estimate VBG cord-010119-t1x9gknd 3090 22 WBC WBC NNP cord-010119-t1x9gknd 3090 23 liters liter NNS cord-010119-t1x9gknd 3090 24 to to TO cord-010119-t1x9gknd 3090 25 be be VB cord-010119-t1x9gknd 3090 26 processed process VBN cord-010119-t1x9gknd 3090 27 to to TO cord-010119-t1x9gknd 3090 28 obtain obtain VB cord-010119-t1x9gknd 3090 29 sufficient sufficient JJ cord-010119-t1x9gknd 3090 30 stem stem NN cord-010119-t1x9gknd 3090 31 cells cell NNS cord-010119-t1x9gknd 3090 32 for for IN cord-010119-t1x9gknd 3090 33 the the DT cord-010119-t1x9gknd 3090 34 transplant transplant NN cord-010119-t1x9gknd 3090 35 . . . cord-010119-t1x9gknd 3091 1 This this DT cord-010119-t1x9gknd 3091 2 algorithm algorithm NN cord-010119-t1x9gknd 3091 3 was be VBD cord-010119-t1x9gknd 3091 4 designed design VBN cord-010119-t1x9gknd 3091 5 using use VBG cord-010119-t1x9gknd 3091 6 linear linear JJ cord-010119-t1x9gknd 3091 7 regression regression NN cord-010119-t1x9gknd 3091 8 of of IN cord-010119-t1x9gknd 3091 9 peripheral peripheral JJ cord-010119-t1x9gknd 3091 10 blood blood NN cord-010119-t1x9gknd 3091 11 CD341 cd341 NN cord-010119-t1x9gknd 3091 12 on on IN cord-010119-t1x9gknd 3091 13 the the DT cord-010119-t1x9gknd 3091 14 day day NN cord-010119-t1x9gknd 3091 15 of of IN cord-010119-t1x9gknd 3091 16 the the DT cord-010119-t1x9gknd 3091 17 collection collection NN cord-010119-t1x9gknd 3091 18 versus versus IN cord-010119-t1x9gknd 3091 19 collected collect VBN cord-010119-t1x9gknd 3091 20 CD341 cd341 NN cord-010119-t1x9gknd 3091 21 per per IN cord-010119-t1x9gknd 3091 22 liter liter NN cord-010119-t1x9gknd 3091 23 of of IN cord-010119-t1x9gknd 3091 24 blood blood NN cord-010119-t1x9gknd 3091 25 processed process VBN cord-010119-t1x9gknd 3091 26 . . . cord-010119-t1x9gknd 3092 1 There there EX cord-010119-t1x9gknd 3092 2 was be VBD cord-010119-t1x9gknd 3092 3 no no DT cord-010119-t1x9gknd 3092 4 distinction distinction NN cord-010119-t1x9gknd 3092 5 between between IN cord-010119-t1x9gknd 3092 6 patients patient NNS cord-010119-t1x9gknd 3092 7 and and CC cord-010119-t1x9gknd 3092 8 donors donor NNS cord-010119-t1x9gknd 3092 9 , , , cord-010119-t1x9gknd 3092 10 once once IN cord-010119-t1x9gknd 3092 11 the the DT cord-010119-t1x9gknd 3092 12 efficiency efficiency NN cord-010119-t1x9gknd 3092 13 coefficient coefficient NN cord-010119-t1x9gknd 3092 14 was be VBD cord-010119-t1x9gknd 3092 15 used use VBN cord-010119-t1x9gknd 3092 16 for for IN cord-010119-t1x9gknd 3092 17 both both DT cord-010119-t1x9gknd 3092 18 . . . cord-010119-t1x9gknd 3093 1 Collected collect VBN cord-010119-t1x9gknd 3093 2 material material NN cord-010119-t1x9gknd 3093 3 was be VBD cord-010119-t1x9gknd 3093 4 sent send VBN cord-010119-t1x9gknd 3093 5 to to IN cord-010119-t1x9gknd 3093 6 analysis analysis NN cord-010119-t1x9gknd 3093 7 and and CC cord-010119-t1x9gknd 3093 8 total total JJ cord-010119-t1x9gknd 3093 9 CD341 cd341 NN cord-010119-t1x9gknd 3093 10 was be VBD cord-010119-t1x9gknd 3093 11 calculated calculate VBN cord-010119-t1x9gknd 3093 12 . . . cord-010119-t1x9gknd 3094 1 Final final JJ cord-010119-t1x9gknd 3094 2 laboratory laboratory NN cord-010119-t1x9gknd 3094 3 count count NN cord-010119-t1x9gknd 3094 4 of of IN cord-010119-t1x9gknd 3094 5 CD341 cd341 NN cord-010119-t1x9gknd 3094 6 per per IN cord-010119-t1x9gknd 3094 7 kilogram kilogram NN cord-010119-t1x9gknd 3094 8 was be VBD cord-010119-t1x9gknd 3094 9 compared compare VBN cord-010119-t1x9gknd 3094 10 with with IN cord-010119-t1x9gknd 3094 11 the the DT cord-010119-t1x9gknd 3094 12 number number NN cord-010119-t1x9gknd 3094 13 predicted predict VBN cord-010119-t1x9gknd 3094 14 by by IN cord-010119-t1x9gknd 3094 15 the the DT cord-010119-t1x9gknd 3094 16 algorithm algorithm NN cord-010119-t1x9gknd 3094 17 with with IN cord-010119-t1x9gknd 3094 18 Spearman Spearman NNP cord-010119-t1x9gknd 3094 19 's 's POS cord-010119-t1x9gknd 3094 20 correlation correlation NN cord-010119-t1x9gknd 3094 21 to to TO cord-010119-t1x9gknd 3094 22 evaluate evaluate VB cord-010119-t1x9gknd 3094 23 whether whether IN cord-010119-t1x9gknd 3094 24 the the DT cord-010119-t1x9gknd 3094 25 formula formula NN cord-010119-t1x9gknd 3094 26 is be VBZ cord-010119-t1x9gknd 3094 27 effective effective JJ cord-010119-t1x9gknd 3094 28 . . . cord-010119-t1x9gknd 3095 1 Calculations calculation NNS cord-010119-t1x9gknd 3095 2 were be VBD cord-010119-t1x9gknd 3095 3 made make VBN cord-010119-t1x9gknd 3095 4 using use VBG cord-010119-t1x9gknd 3095 5 IBM IBM NNP cord-010119-t1x9gknd 3095 6 SPSS SPSS NNP cord-010119-t1x9gknd 3095 7 23 23 CD cord-010119-t1x9gknd 3095 8 Software Software NNP cord-010119-t1x9gknd 3095 9 . . . cord-010119-t1x9gknd 3096 1 Results result NNS cord-010119-t1x9gknd 3096 2 / / SYM cord-010119-t1x9gknd 3096 3 Findings finding NNS cord-010119-t1x9gknd 3096 4 : : : cord-010119-t1x9gknd 3097 1 Among among IN cord-010119-t1x9gknd 3097 2 patients patient NNS cord-010119-t1x9gknd 3097 3 collecting collect VBG cord-010119-t1x9gknd 3097 4 HPC hpc NN cord-010119-t1x9gknd 3097 5 for for IN cord-010119-t1x9gknd 3097 6 autologous autologous JJ cord-010119-t1x9gknd 3097 7 transplantation transplantation NN cord-010119-t1x9gknd 3097 8 , , , cord-010119-t1x9gknd 3097 9 69,23 69,23 CD cord-010119-t1x9gknd 3097 10 % % NN cord-010119-t1x9gknd 3097 11 needed need VBD cord-010119-t1x9gknd 3097 12 only only RB cord-010119-t1x9gknd 3097 13 one one CD cord-010119-t1x9gknd 3097 14 day day NN cord-010119-t1x9gknd 3097 15 of of IN cord-010119-t1x9gknd 3097 16 HPC HPC NNP cord-010119-t1x9gknd 3097 17 harvesting harvesting NN cord-010119-t1x9gknd 3097 18 , , , cord-010119-t1x9gknd 3097 19 while while IN cord-010119-t1x9gknd 3097 20 25,64 25,64 CD cord-010119-t1x9gknd 3097 21 % % NN cord-010119-t1x9gknd 3097 22 needed need VBD cord-010119-t1x9gknd 3097 23 two two CD cord-010119-t1x9gknd 3097 24 days day NNS cord-010119-t1x9gknd 3097 25 and and CC cord-010119-t1x9gknd 3097 26 5,13 5,13 CD cord-010119-t1x9gknd 3097 27 % % NN cord-010119-t1x9gknd 3097 28 needed need VBD cord-010119-t1x9gknd 3097 29 three three CD cord-010119-t1x9gknd 3097 30 or or CC cord-010119-t1x9gknd 3097 31 more more JJR cord-010119-t1x9gknd 3097 32 days day NNS cord-010119-t1x9gknd 3097 33 . . . cord-010119-t1x9gknd 3098 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3098 2 collection collection NN cord-010119-t1x9gknd 3098 3 efficiency efficiency NN cord-010119-t1x9gknd 3098 4 ( ( -LRB- cord-010119-t1x9gknd 3098 5 CE CE NNP cord-010119-t1x9gknd 3098 6 ) ) -RRB- cord-010119-t1x9gknd 3098 7 and and CC cord-010119-t1x9gknd 3098 8 standard standard JJ cord-010119-t1x9gknd 3098 9 error error NN cord-010119-t1x9gknd 3098 10 of of IN cord-010119-t1x9gknd 3098 11 the the DT cord-010119-t1x9gknd 3098 12 mean mean JJ cord-010119-t1x9gknd 3098 13 ( ( -LRB- cord-010119-t1x9gknd 3098 14 SEM SEM NNP cord-010119-t1x9gknd 3098 15 ) ) -RRB- cord-010119-t1x9gknd 3098 16 was be VBD cord-010119-t1x9gknd 3098 17 49 49 CD cord-010119-t1x9gknd 3098 18 1 1 CD cord-010119-t1x9gknd 3098 19 - - HYPH cord-010119-t1x9gknd 3098 20 2,91 2,91 CD cord-010119-t1x9gknd 3098 21 % % NN cord-010119-t1x9gknd 3098 22 . . . cord-010119-t1x9gknd 3099 1 After after IN cord-010119-t1x9gknd 3099 2 comparing compare VBG cord-010119-t1x9gknd 3099 3 predicted predict VBN cord-010119-t1x9gknd 3099 4 values value NNS cord-010119-t1x9gknd 3099 5 with with IN cord-010119-t1x9gknd 3099 6 CD341 cd341 NN cord-010119-t1x9gknd 3099 7 collected collect VBN cord-010119-t1x9gknd 3099 8 in in IN cord-010119-t1x9gknd 3099 9 the the DT cord-010119-t1x9gknd 3099 10 final final JJ cord-010119-t1x9gknd 3099 11 product product NN cord-010119-t1x9gknd 3099 12 , , , cord-010119-t1x9gknd 3099 13 we -PRON- PRP cord-010119-t1x9gknd 3099 14 found find VBD cord-010119-t1x9gknd 3099 15 a a DT cord-010119-t1x9gknd 3099 16 very very RB cord-010119-t1x9gknd 3099 17 strong strong JJ cord-010119-t1x9gknd 3099 18 correlation correlation NN cord-010119-t1x9gknd 3099 19 of of IN cord-010119-t1x9gknd 3099 20 0.873 0.873 CD cord-010119-t1x9gknd 3099 21 ( ( -LRB- cord-010119-t1x9gknd 3099 22 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 3099 23 ) ) -RRB- cord-010119-t1x9gknd 3099 24 for for IN cord-010119-t1x9gknd 3099 25 patients patient NNS cord-010119-t1x9gknd 3099 26 and and CC cord-010119-t1x9gknd 3099 27 a a DT cord-010119-t1x9gknd 3099 28 strong strong JJ cord-010119-t1x9gknd 3099 29 correlation correlation NN cord-010119-t1x9gknd 3099 30 0.653 0.653 CD cord-010119-t1x9gknd 3099 31 for for IN cord-010119-t1x9gknd 3099 32 healthy healthy JJ cord-010119-t1x9gknd 3099 33 donors donor NNS cord-010119-t1x9gknd 3099 34 ( ( -LRB- cord-010119-t1x9gknd 3099 35 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 3099 36 ) ) -RRB- cord-010119-t1x9gknd 3099 37 . . . cord-010119-t1x9gknd 3100 1 Conclusion conclusion NN cord-010119-t1x9gknd 3100 2 : : : cord-010119-t1x9gknd 3101 1 The the DT cord-010119-t1x9gknd 3101 2 use use NN cord-010119-t1x9gknd 3101 3 of of IN cord-010119-t1x9gknd 3101 4 a a DT cord-010119-t1x9gknd 3101 5 mathematical mathematical JJ cord-010119-t1x9gknd 3101 6 model model NN cord-010119-t1x9gknd 3101 7 with with IN cord-010119-t1x9gknd 3101 8 a a DT cord-010119-t1x9gknd 3101 9 prediction prediction NN cord-010119-t1x9gknd 3101 10 algorithm algorithm NN cord-010119-t1x9gknd 3101 11 is be VBZ cord-010119-t1x9gknd 3101 12 safe safe JJ cord-010119-t1x9gknd 3101 13 , , , cord-010119-t1x9gknd 3101 14 has have VBZ cord-010119-t1x9gknd 3101 15 low low JJ cord-010119-t1x9gknd 3101 16 cost cost NN cord-010119-t1x9gknd 3101 17 and and CC cord-010119-t1x9gknd 3101 18 provides provide VBZ cord-010119-t1x9gknd 3101 19 a a DT cord-010119-t1x9gknd 3101 20 good good JJ cord-010119-t1x9gknd 3101 21 tool tool NN cord-010119-t1x9gknd 3101 22 to to TO cord-010119-t1x9gknd 3101 23 estimate estimate VB cord-010119-t1x9gknd 3101 24 WB WB NNP cord-010119-t1x9gknd 3101 25 liters liter NNS cord-010119-t1x9gknd 3101 26 to to TO cord-010119-t1x9gknd 3101 27 process process VB cord-010119-t1x9gknd 3101 28 and and CC cord-010119-t1x9gknd 3101 29 avoid avoid VB cord-010119-t1x9gknd 3101 30 unnecessary unnecessary JJ cord-010119-t1x9gknd 3101 31 procedures procedure NNS cord-010119-t1x9gknd 3101 32 in in IN cord-010119-t1x9gknd 3101 33 both both DT cord-010119-t1x9gknd 3101 34 patients patient NNS cord-010119-t1x9gknd 3101 35 and and CC cord-010119-t1x9gknd 3101 36 healthy healthy JJ cord-010119-t1x9gknd 3101 37 donors donor NNS cord-010119-t1x9gknd 3101 38 . . . cord-010119-t1x9gknd 3102 1 This this DT cord-010119-t1x9gknd 3102 2 study study NN cord-010119-t1x9gknd 3102 3 evaluated evaluate VBD cord-010119-t1x9gknd 3102 4 the the DT cord-010119-t1x9gknd 3102 5 phenotypic phenotypic JJ cord-010119-t1x9gknd 3102 6 characteristics characteristic NNS cord-010119-t1x9gknd 3102 7 of of IN cord-010119-t1x9gknd 3102 8 UC UC NNP cord-010119-t1x9gknd 3102 9 - - HYPH cord-010119-t1x9gknd 3102 10 MSCs MSCs NNP cord-010119-t1x9gknd 3102 11 derived derive VBN cord-010119-t1x9gknd 3102 12 from from IN cord-010119-t1x9gknd 3102 13 fresh fresh JJ cord-010119-t1x9gknd 3102 14 and and CC cord-010119-t1x9gknd 3102 15 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 3102 16 cord cord NN cord-010119-t1x9gknd 3102 17 tissues tissue NNS cord-010119-t1x9gknd 3102 18 ( ( -LRB- cord-010119-t1x9gknd 3102 19 CT CT NNP cord-010119-t1x9gknd 3102 20 ) ) -RRB- cord-010119-t1x9gknd 3102 21 , , , cord-010119-t1x9gknd 3102 22 as as IN cord-010119-t1x9gknd 3102 23 described describe VBN cord-010119-t1x9gknd 3102 24 in in IN cord-010119-t1x9gknd 3102 25 ISCT ISCT NNP cord-010119-t1x9gknd 3102 26 's 's POS cord-010119-t1x9gknd 3102 27 position position NN cord-010119-t1x9gknd 3102 28 paper paper NN cord-010119-t1x9gknd 3102 29 on on IN cord-010119-t1x9gknd 3102 30 minimal minimal JJ cord-010119-t1x9gknd 3102 31 characteristics characteristic NNS cord-010119-t1x9gknd 3102 32 of of IN cord-010119-t1x9gknd 3102 33 mesenchymal mesenchymal JJ cord-010119-t1x9gknd 3102 34 stem stem NN cord-010119-t1x9gknd 3102 35 cells cell NNS cord-010119-t1x9gknd 3102 36 ( ( -LRB- cord-010119-t1x9gknd 3102 37 plastic plastic JJ cord-010119-t1x9gknd 3102 38 adherent adherent NN cord-010119-t1x9gknd 3102 39 ; ; : cord-010119-t1x9gknd 3102 40 ! ! . cord-010119-t1x9gknd 3103 1 95 95 CD cord-010119-t1x9gknd 3103 2 % % NN cord-010119-t1x9gknd 3103 3 CD90 CD90 NNP cord-010119-t1x9gknd 3103 4 , , , cord-010119-t1x9gknd 3103 5 CD105 CD105 NNP cord-010119-t1x9gknd 3103 6 , , , cord-010119-t1x9gknd 3103 7 CD73 CD73 NNP cord-010119-t1x9gknd 3103 8 and and CC cord-010119-t1x9gknd 3103 9 2 2 CD cord-010119-t1x9gknd 3103 10 % % NN cord-010119-t1x9gknd 3103 11 CD14 CD14 NNP cord-010119-t1x9gknd 3103 12 , , , cord-010119-t1x9gknd 3103 13 CD19 CD19 NNP cord-010119-t1x9gknd 3103 14 , , , cord-010119-t1x9gknd 3103 15 CD34 CD34 NNP cord-010119-t1x9gknd 3103 16 , , , cord-010119-t1x9gknd 3103 17 CD45 CD45 NNP cord-010119-t1x9gknd 3103 18 , , , cord-010119-t1x9gknd 3103 19 HLA HLA NNP cord-010119-t1x9gknd 3103 20 - - HYPH cord-010119-t1x9gknd 3103 21 DR DR NNP cord-010119-t1x9gknd 3103 22 ) ) -RRB- cord-010119-t1x9gknd 3103 23 Study Study NNP cord-010119-t1x9gknd 3103 24 Design Design NNP cord-010119-t1x9gknd 3103 25 / / SYM cord-010119-t1x9gknd 3103 26 Method method NN cord-010119-t1x9gknd 3103 27 : : : cord-010119-t1x9gknd 3104 1 Umbilical umbilical JJ cord-010119-t1x9gknd 3104 2 cord cord NN cord-010119-t1x9gknd 3104 3 tissue tissue NN cord-010119-t1x9gknd 3104 4 ( ( -LRB- cord-010119-t1x9gknd 3104 5 N510 N510 NNP cord-010119-t1x9gknd 3104 6 ) ) -RRB- cord-010119-t1x9gknd 3104 7 was be VBD cord-010119-t1x9gknd 3104 8 washed wash VBN cord-010119-t1x9gknd 3104 9 , , , cord-010119-t1x9gknd 3104 10 blood blood NN cord-010119-t1x9gknd 3104 11 vessels vessel NNS cord-010119-t1x9gknd 3104 12 removed remove VBN cord-010119-t1x9gknd 3104 13 , , , cord-010119-t1x9gknd 3104 14 cut cut VBN cord-010119-t1x9gknd 3104 15 into into IN cord-010119-t1x9gknd 3104 16 0.5 0.5 CD cord-010119-t1x9gknd 3104 17 - - SYM cord-010119-t1x9gknd 3104 18 3 3 CD cord-010119-t1x9gknd 3104 19 mm mm NN cord-010119-t1x9gknd 3104 20 pieces piece NNS cord-010119-t1x9gknd 3104 21 , , , cord-010119-t1x9gknd 3104 22 and and CC cord-010119-t1x9gknd 3104 23 washed wash VBD cord-010119-t1x9gknd 3104 24 twice twice RB cord-010119-t1x9gknd 3104 25 in in IN cord-010119-t1x9gknd 3104 26 saline saline NN cord-010119-t1x9gknd 3104 27 . . . cord-010119-t1x9gknd 3105 1 Fresh fresh JJ cord-010119-t1x9gknd 3105 2 tissue tissue NN cord-010119-t1x9gknd 3105 3 was be VBD cord-010119-t1x9gknd 3105 4 immersed immerse VBN cord-010119-t1x9gknd 3105 5 in in IN cord-010119-t1x9gknd 3105 6 0.9 0.9 CD cord-010119-t1x9gknd 3105 7 % % NN cord-010119-t1x9gknd 3105 8 saline saline NN cord-010119-t1x9gknd 3105 9 for for IN cord-010119-t1x9gknd 3105 10 same same JJ cord-010119-t1x9gknd 3105 11 day day NN cord-010119-t1x9gknd 3105 12 culture culture NN cord-010119-t1x9gknd 3105 13 , , , cord-010119-t1x9gknd 3105 14 while while IN cord-010119-t1x9gknd 3105 15 frozen frozen JJ cord-010119-t1x9gknd 3105 16 tissue tissue NN cord-010119-t1x9gknd 3105 17 was be VBD cord-010119-t1x9gknd 3105 18 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3105 19 for for IN cord-010119-t1x9gknd 3105 20 at at RB cord-010119-t1x9gknd 3105 21 least least RBS cord-010119-t1x9gknd 3105 22 24 24 CD cord-010119-t1x9gknd 3105 23 hours hour NNS cord-010119-t1x9gknd 3105 24 prior prior RB cord-010119-t1x9gknd 3105 25 to to IN cord-010119-t1x9gknd 3105 26 culture culture NN cord-010119-t1x9gknd 3105 27 . . . cord-010119-t1x9gknd 3106 1 For for IN cord-010119-t1x9gknd 3106 2 colony colony NN cord-010119-t1x9gknd 3106 3 forming form VBG cord-010119-t1x9gknd 3106 4 unit unit NN cord-010119-t1x9gknd 3106 5 ( ( -LRB- cord-010119-t1x9gknd 3106 6 CFU CFU NNP cord-010119-t1x9gknd 3106 7 ) ) -RRB- cord-010119-t1x9gknd 3106 8 testing testing NN cord-010119-t1x9gknd 3106 9 tissue tissue NN cord-010119-t1x9gknd 3106 10 was be VBD cord-010119-t1x9gknd 3106 11 plated plate VBN cord-010119-t1x9gknd 3106 12 directly directly RB cord-010119-t1x9gknd 3106 13 in in IN cord-010119-t1x9gknd 3106 14 a a DT cord-010119-t1x9gknd 3106 15 25 25 CD cord-010119-t1x9gknd 3106 16 cm cm NN cord-010119-t1x9gknd 3106 17 2 2 CD cord-010119-t1x9gknd 3106 18 tissue tissue NN cord-010119-t1x9gknd 3106 19 culture culture NN cord-010119-t1x9gknd 3106 20 flask flask NN cord-010119-t1x9gknd 3106 21 following follow VBG cord-010119-t1x9gknd 3106 22 a a DT cord-010119-t1x9gknd 3106 23 wash wash NN cord-010119-t1x9gknd 3106 24 in in IN cord-010119-t1x9gknd 3106 25 PBS PBS NNP cord-010119-t1x9gknd 3106 26 with with IN cord-010119-t1x9gknd 3106 27 antibiotic antibiotic NN cord-010119-t1x9gknd 3106 28 / / SYM cord-010119-t1x9gknd 3106 29 antimycotic antimycotic JJ cord-010119-t1x9gknd 3106 30 . . . cord-010119-t1x9gknd 3107 1 The the DT cord-010119-t1x9gknd 3107 2 tissue tissue NN cord-010119-t1x9gknd 3107 3 was be VBD cord-010119-t1x9gknd 3107 4 allowed allow VBN cord-010119-t1x9gknd 3107 5 to to TO cord-010119-t1x9gknd 3107 6 adhere adhere VB cord-010119-t1x9gknd 3107 7 for for IN cord-010119-t1x9gknd 3107 8 10 10 CD cord-010119-t1x9gknd 3107 9 minutes minute NNS cord-010119-t1x9gknd 3107 10 prior prior RB cord-010119-t1x9gknd 3107 11 to to IN cord-010119-t1x9gknd 3107 12 the the DT cord-010119-t1x9gknd 3107 13 addition addition NN cord-010119-t1x9gknd 3107 14 of of IN cord-010119-t1x9gknd 3107 15 cell cell NN cord-010119-t1x9gknd 3107 16 culture culture NN cord-010119-t1x9gknd 3107 17 media medium NNS cord-010119-t1x9gknd 3107 18 . . . cord-010119-t1x9gknd 3108 1 Media Media NNP cord-010119-t1x9gknd 3108 2 was be VBD cord-010119-t1x9gknd 3108 3 changed change VBN cord-010119-t1x9gknd 3108 4 several several JJ cord-010119-t1x9gknd 3108 5 times time NNS cord-010119-t1x9gknd 3108 6 a a DT cord-010119-t1x9gknd 3108 7 week week NN cord-010119-t1x9gknd 3108 8 . . . cord-010119-t1x9gknd 3109 1 Cells cell NNS cord-010119-t1x9gknd 3109 2 were be VBD cord-010119-t1x9gknd 3109 3 passed pass VBN cord-010119-t1x9gknd 3109 4 when when WRB cord-010119-t1x9gknd 3109 5 robust robust JJ cord-010119-t1x9gknd 3109 6 colony colony NN cord-010119-t1x9gknd 3109 7 growth growth NN cord-010119-t1x9gknd 3109 8 was be VBD cord-010119-t1x9gknd 3109 9 observed observe VBN cord-010119-t1x9gknd 3109 10 and and CC cord-010119-t1x9gknd 3109 11 in in IN cord-010119-t1x9gknd 3109 12 subsequent subsequent JJ cord-010119-t1x9gknd 3109 13 cultures culture NNS cord-010119-t1x9gknd 3109 14 > > NFP cord-010119-t1x9gknd 3109 15 80 80 CD cord-010119-t1x9gknd 3109 16 % % NN cord-010119-t1x9gknd 3109 17 confluence confluence NN cord-010119-t1x9gknd 3109 18 . . . cord-010119-t1x9gknd 3110 1 All all DT cord-010119-t1x9gknd 3110 2 cells cell NNS cord-010119-t1x9gknd 3110 3 were be VBD cord-010119-t1x9gknd 3110 4 tested test VBN cord-010119-t1x9gknd 3110 5 on on IN cord-010119-t1x9gknd 3110 6 an an DT cord-010119-t1x9gknd 3110 7 MSC MSC NNP cord-010119-t1x9gknd 3110 8 flow flow NN cord-010119-t1x9gknd 3110 9 panel panel NN cord-010119-t1x9gknd 3110 10 at at IN cord-010119-t1x9gknd 3110 11 passage passage NN cord-010119-t1x9gknd 3110 12 2 2 CD cord-010119-t1x9gknd 3110 13 just just RB cord-010119-t1x9gknd 3110 14 prior prior RB cord-010119-t1x9gknd 3110 15 to to IN cord-010119-t1x9gknd 3110 16 confluence confluence NN cord-010119-t1x9gknd 3110 17 . . . cord-010119-t1x9gknd 3111 1 Results result NNS cord-010119-t1x9gknd 3111 2 / / SYM cord-010119-t1x9gknd 3111 3 Finding finding NN cord-010119-t1x9gknd 3112 1 : : : cord-010119-t1x9gknd 3112 2 Both both CC cord-010119-t1x9gknd 3112 3 fresh fresh JJ cord-010119-t1x9gknd 3112 4 and and CC cord-010119-t1x9gknd 3112 5 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 3112 6 tissue tissue NN cord-010119-t1x9gknd 3112 7 showed show VBD cord-010119-t1x9gknd 3112 8 excellent excellent JJ cord-010119-t1x9gknd 3112 9 colony colony NN cord-010119-t1x9gknd 3112 10 forming form VBG cord-010119-t1x9gknd 3112 11 capabilities capability NNS cord-010119-t1x9gknd 3112 12 . . . cord-010119-t1x9gknd 3113 1 Average average JJ cord-010119-t1x9gknd 3113 2 time time NN cord-010119-t1x9gknd 3113 3 for for IN cord-010119-t1x9gknd 3113 4 cellular cellular JJ cord-010119-t1x9gknd 3113 5 emergence emergence NN cord-010119-t1x9gknd 3113 6 of of IN cord-010119-t1x9gknd 3113 7 8 8 CD cord-010119-t1x9gknd 3113 8 days day NNS cord-010119-t1x9gknd 3113 9 ( ( -LRB- cord-010119-t1x9gknd 3113 10 Fresh fresh JJ cord-010119-t1x9gknd 3113 11 5 5 CD cord-010119-t1x9gknd 3113 12 7.8 7.8 CD cord-010119-t1x9gknd 3113 13 , , , cord-010119-t1x9gknd 3113 14 Frozen Frozen NNP cord-010119-t1x9gknd 3113 15 5 5 CD cord-010119-t1x9gknd 3113 16 8.1 8.1 CD cord-010119-t1x9gknd 3113 17 ) ) -RRB- cord-010119-t1x9gknd 3113 18 , , , cord-010119-t1x9gknd 3113 19 and and CC cord-010119-t1x9gknd 3113 20 13 13 CD cord-010119-t1x9gknd 3113 21 days day NNS cord-010119-t1x9gknd 3113 22 ( ( -LRB- cord-010119-t1x9gknd 3113 23 total total NN cord-010119-t1x9gknd 3113 24 ) ) -RRB- cord-010119-t1x9gknd 3113 25 for for IN cord-010119-t1x9gknd 3113 26 the the DT cord-010119-t1x9gknd 3113 27 MSC MSC NNP cord-010119-t1x9gknd 3113 28 's 's POS cord-010119-t1x9gknd 3113 29 to to TO cord-010119-t1x9gknd 3113 30 reach reach VB cord-010119-t1x9gknd 3113 31 passage passage NN cord-010119-t1x9gknd 3113 32 1 1 CD cord-010119-t1x9gknd 3114 1 ( ( -LRB- cord-010119-t1x9gknd 3114 2 Fresh fresh JJ cord-010119-t1x9gknd 3114 3 5 5 CD cord-010119-t1x9gknd 3114 4 12.6 12.6 CD cord-010119-t1x9gknd 3114 5 , , , cord-010119-t1x9gknd 3114 6 Frozen Frozen NNP cord-010119-t1x9gknd 3114 7 13.4 13.4 CD cord-010119-t1x9gknd 3114 8 ) ) -RRB- cord-010119-t1x9gknd 3114 9 . . . cord-010119-t1x9gknd 3115 1 All all DT cord-010119-t1x9gknd 3115 2 cells cell NNS cord-010119-t1x9gknd 3115 3 were be VBD cord-010119-t1x9gknd 3115 4 ready ready JJ cord-010119-t1x9gknd 3115 5 for for IN cord-010119-t1x9gknd 3115 6 flow flow NN cord-010119-t1x9gknd 3115 7 analysis analysis NN cord-010119-t1x9gknd 3115 8 in in IN cord-010119-t1x9gknd 3115 9 approximately approximately RB cord-010119-t1x9gknd 3115 10 3 3 CD cord-010119-t1x9gknd 3115 11 weeks week NNS cord-010119-t1x9gknd 3115 12 time time NN cord-010119-t1x9gknd 3115 13 . . . cord-010119-t1x9gknd 3116 1 There there EX cord-010119-t1x9gknd 3116 2 was be VBD cord-010119-t1x9gknd 3116 3 no no DT cord-010119-t1x9gknd 3116 4 statistical statistical JJ cord-010119-t1x9gknd 3116 5 difference difference NN cord-010119-t1x9gknd 3116 6 between between IN cord-010119-t1x9gknd 3116 7 fresh fresh JJ cord-010119-t1x9gknd 3116 8 and and CC cord-010119-t1x9gknd 3116 9 frozen frozen JJ cord-010119-t1x9gknd 3116 10 tissue tissue NN cord-010119-t1x9gknd 3116 11 in in IN cord-010119-t1x9gknd 3116 12 their -PRON- PRP$ cord-010119-t1x9gknd 3116 13 colony colony NN cord-010119-t1x9gknd 3116 14 emergence emergence NN cord-010119-t1x9gknd 3116 15 ( ( -LRB- cord-010119-t1x9gknd 3116 16 p p NN cord-010119-t1x9gknd 3116 17 5 5 CD cord-010119-t1x9gknd 3116 18 0.81 0.81 CD cord-010119-t1x9gknd 3116 19 ) ) -RRB- cord-010119-t1x9gknd 3116 20 , , , cord-010119-t1x9gknd 3116 21 or or CC cord-010119-t1x9gknd 3116 22 their -PRON- PRP$ cord-010119-t1x9gknd 3116 23 growth growth NN cord-010119-t1x9gknd 3116 24 rates rate NNS cord-010119-t1x9gknd 3116 25 ( ( -LRB- cord-010119-t1x9gknd 3116 26 p p NN cord-010119-t1x9gknd 3116 27 > > XX cord-010119-t1x9gknd 3116 28 0.05 0.05 CD cord-010119-t1x9gknd 3116 29 for for IN cord-010119-t1x9gknd 3116 30 all all DT cord-010119-t1x9gknd 3116 31 ) ) -RRB- cord-010119-t1x9gknd 3116 32 . . . cord-010119-t1x9gknd 3117 1 Flow flow NN cord-010119-t1x9gknd 3117 2 cytometry cytometry NN cord-010119-t1x9gknd 3117 3 showed show VBD cord-010119-t1x9gknd 3117 4 average average JJ cord-010119-t1x9gknd 3117 5 ! ! . cord-010119-t1x9gknd 3118 1 95 95 CD cord-010119-t1x9gknd 3118 2 % % NN cord-010119-t1x9gknd 3118 3 for for IN cord-010119-t1x9gknd 3118 4 positive positive JJ cord-010119-t1x9gknd 3118 5 markers marker NNS cord-010119-t1x9gknd 3118 6 and and CC cord-010119-t1x9gknd 3118 7 2 2 CD cord-010119-t1x9gknd 3118 8 % % NN cord-010119-t1x9gknd 3118 9 negative negative JJ cord-010119-t1x9gknd 3118 10 markers marker NNS cord-010119-t1x9gknd 3118 11 . . . cord-010119-t1x9gknd 3119 1 There there EX cord-010119-t1x9gknd 3119 2 was be VBD cord-010119-t1x9gknd 3119 3 no no DT cord-010119-t1x9gknd 3119 4 statistical statistical JJ cord-010119-t1x9gknd 3119 5 difference difference NN cord-010119-t1x9gknd 3119 6 between between IN cord-010119-t1x9gknd 3119 7 fresh fresh JJ cord-010119-t1x9gknd 3119 8 and and CC cord-010119-t1x9gknd 3119 9 frozen frozen JJ cord-010119-t1x9gknd 3119 10 flow flow NN cord-010119-t1x9gknd 3119 11 result result NN cord-010119-t1x9gknd 3119 12 ( ( -LRB- cord-010119-t1x9gknd 3119 13 p p NN cord-010119-t1x9gknd 3119 14 > > XX cord-010119-t1x9gknd 3119 15 0.05 0.05 CD cord-010119-t1x9gknd 3119 16 ) ) -RRB- cord-010119-t1x9gknd 3119 17 . . . cord-010119-t1x9gknd 3120 1 Conclusion conclusion NN cord-010119-t1x9gknd 3120 2 : : : cord-010119-t1x9gknd 3120 3 UC UC NNP cord-010119-t1x9gknd 3120 4 - - HYPH cord-010119-t1x9gknd 3120 5 MSC MSC NNP cord-010119-t1x9gknd 3120 6 's 's POS cord-010119-t1x9gknd 3120 7 show show NN cord-010119-t1x9gknd 3120 8 excellent excellent JJ cord-010119-t1x9gknd 3120 9 adherence adherence NN cord-010119-t1x9gknd 3120 10 to to IN cord-010119-t1x9gknd 3120 11 plastic plastic NN cord-010119-t1x9gknd 3120 12 in in IN cord-010119-t1x9gknd 3120 13 both both CC cord-010119-t1x9gknd 3120 14 fresh fresh JJ cord-010119-t1x9gknd 3120 15 and and CC cord-010119-t1x9gknd 3120 16 frozen frozen JJ cord-010119-t1x9gknd 3120 17 explant explant NN cord-010119-t1x9gknd 3120 18 cultures culture NNS cord-010119-t1x9gknd 3120 19 , , , cord-010119-t1x9gknd 3120 20 with with IN cord-010119-t1x9gknd 3120 21 a a DT cord-010119-t1x9gknd 3120 22 consistent consistent JJ cord-010119-t1x9gknd 3120 23 fibroblast fibroblast NN cord-010119-t1x9gknd 3120 24 - - HYPH cord-010119-t1x9gknd 3120 25 like like JJ cord-010119-t1x9gknd 3120 26 morphology morphology NN cord-010119-t1x9gknd 3120 27 . . . cord-010119-t1x9gknd 3121 1 Flow flow NN cord-010119-t1x9gknd 3121 2 cytometry cytometry NN cord-010119-t1x9gknd 3121 3 analysis analysis NN cord-010119-t1x9gknd 3121 4 showed show VBD cord-010119-t1x9gknd 3121 5 strong strong JJ cord-010119-t1x9gknd 3121 6 MSC MSC NNP cord-010119-t1x9gknd 3121 7 phenotype phenotype NN cord-010119-t1x9gknd 3121 8 in in IN cord-010119-t1x9gknd 3121 9 both both CC cord-010119-t1x9gknd 3121 10 fresh fresh JJ cord-010119-t1x9gknd 3121 11 and and CC cord-010119-t1x9gknd 3121 12 frozen frozen JJ cord-010119-t1x9gknd 3121 13 samples sample NNS cord-010119-t1x9gknd 3121 14 . . . cord-010119-t1x9gknd 3122 1 The the DT cord-010119-t1x9gknd 3122 2 data datum NNS cord-010119-t1x9gknd 3122 3 show show VBP cord-010119-t1x9gknd 3122 4 that that IN cord-010119-t1x9gknd 3122 5 the the DT cord-010119-t1x9gknd 3122 6 cryogenic cryogenic JJ cord-010119-t1x9gknd 3122 7 process process NN cord-010119-t1x9gknd 3122 8 does do VBZ cord-010119-t1x9gknd 3122 9 not not RB cord-010119-t1x9gknd 3122 10 appear appear VB cord-010119-t1x9gknd 3122 11 to to TO cord-010119-t1x9gknd 3122 12 have have VB cord-010119-t1x9gknd 3122 13 any any DT cord-010119-t1x9gknd 3122 14 detrimental detrimental JJ cord-010119-t1x9gknd 3122 15 effects effect NNS cord-010119-t1x9gknd 3122 16 on on IN cord-010119-t1x9gknd 3122 17 the the DT cord-010119-t1x9gknd 3122 18 ability ability NN cord-010119-t1x9gknd 3122 19 to to TO cord-010119-t1x9gknd 3122 20 obtain obtain VB cord-010119-t1x9gknd 3122 21 MSC MSC NNP cord-010119-t1x9gknd 3122 22 colonies colony NNS cord-010119-t1x9gknd 3122 23 . . . cord-010119-t1x9gknd 3123 1 Studies study NNS cord-010119-t1x9gknd 3123 2 have have VBP cord-010119-t1x9gknd 3123 3 shown show VBN cord-010119-t1x9gknd 3123 4 that that IN cord-010119-t1x9gknd 3123 5 HSCT HSCT NNP cord-010119-t1x9gknd 3123 6 improves improve VBZ cord-010119-t1x9gknd 3123 7 survival survival NN cord-010119-t1x9gknd 3123 8 and and CC cord-010119-t1x9gknd 3123 9 disease disease NN cord-010119-t1x9gknd 3123 10 - - HYPH cord-010119-t1x9gknd 3123 11 free free JJ cord-010119-t1x9gknd 3123 12 survival survival NN cord-010119-t1x9gknd 3123 13 rates rate NNS cord-010119-t1x9gknd 3123 14 when when WRB cord-010119-t1x9gknd 3123 15 compared compare VBN cord-010119-t1x9gknd 3123 16 to to IN cord-010119-t1x9gknd 3123 17 conventional conventional JJ cord-010119-t1x9gknd 3123 18 chemotherapy chemotherapy NN cord-010119-t1x9gknd 3123 19 treatments treatment NNS cord-010119-t1x9gknd 3123 20 . . . cord-010119-t1x9gknd 3124 1 The the DT cord-010119-t1x9gknd 3124 2 increase increase NN cord-010119-t1x9gknd 3124 3 in in IN cord-010119-t1x9gknd 3124 4 the the DT cord-010119-t1x9gknd 3124 5 number number NN cord-010119-t1x9gknd 3124 6 of of IN cord-010119-t1x9gknd 3124 7 HSCTs hsct NNS cord-010119-t1x9gknd 3124 8 over over IN cord-010119-t1x9gknd 3124 9 the the DT cord-010119-t1x9gknd 3124 10 last last JJ cord-010119-t1x9gknd 3124 11 years year NNS cord-010119-t1x9gknd 3124 12 has have VBZ cord-010119-t1x9gknd 3124 13 demanded demand VBN cord-010119-t1x9gknd 3124 14 quality quality NN cord-010119-t1x9gknd 3124 15 and and CC cord-010119-t1x9gknd 3124 16 safety safety NN cord-010119-t1x9gknd 3124 17 improvements improvement NNS cord-010119-t1x9gknd 3124 18 of of IN cord-010119-t1x9gknd 3124 19 cell cell NN cord-010119-t1x9gknd 3124 20 processing processing NN cord-010119-t1x9gknd 3124 21 and and CC cord-010119-t1x9gknd 3124 22 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3124 23 services service NNS cord-010119-t1x9gknd 3124 24 . . . cord-010119-t1x9gknd 3125 1 Cell cell NN cord-010119-t1x9gknd 3125 2 recovery recovery NN cord-010119-t1x9gknd 3125 3 and and CC cord-010119-t1x9gknd 3125 4 viability viability NN cord-010119-t1x9gknd 3125 5 are be VBP cord-010119-t1x9gknd 3125 6 crucial crucial JJ cord-010119-t1x9gknd 3125 7 parameters parameter NNS cord-010119-t1x9gknd 3125 8 to to TO cord-010119-t1x9gknd 3125 9 assess assess VB cord-010119-t1x9gknd 3125 10 UCB UCB NNP cord-010119-t1x9gknd 3125 11 quality quality NN cord-010119-t1x9gknd 3125 12 as as IN cord-010119-t1x9gknd 3125 13 a a DT cord-010119-t1x9gknd 3125 14 viable viable JJ cord-010119-t1x9gknd 3125 15 HSCT HSCT NNP cord-010119-t1x9gknd 3125 16 graft graft NN cord-010119-t1x9gknd 3125 17 source source NN cord-010119-t1x9gknd 3125 18 . . . cord-010119-t1x9gknd 3126 1 Study Study NNP cord-010119-t1x9gknd 3126 2 Design Design NNP cord-010119-t1x9gknd 3126 3 / / SYM cord-010119-t1x9gknd 3126 4 Method method NN cord-010119-t1x9gknd 3126 5 : : : cord-010119-t1x9gknd 3127 1 Twenty twenty CD cord-010119-t1x9gknd 3127 2 - - HYPH cord-010119-t1x9gknd 3127 3 five five CD cord-010119-t1x9gknd 3127 4 UCB UCB NNP cord-010119-t1x9gknd 3127 5 units unit NNS cord-010119-t1x9gknd 3127 6 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3127 7 for for IN cord-010119-t1x9gknd 3127 8 periods period NNS cord-010119-t1x9gknd 3127 9 of of IN cord-010119-t1x9gknd 3127 10 2 2 CD cord-010119-t1x9gknd 3127 11 up up IN cord-010119-t1x9gknd 3127 12 to to TO cord-010119-t1x9gknd 3127 13 11 11 CD cord-010119-t1x9gknd 3127 14 years year NNS cord-010119-t1x9gknd 3127 15 ( ( -LRB- cord-010119-t1x9gknd 3127 16 2004 2004 CD cord-010119-t1x9gknd 3127 17 to to IN cord-010119-t1x9gknd 3127 18 2017 2017 CD cord-010119-t1x9gknd 3127 19 ) ) -RRB- cord-010119-t1x9gknd 3127 20 were be VBD cord-010119-t1x9gknd 3127 21 analyzed analyze VBN cord-010119-t1x9gknd 3127 22 . . . cord-010119-t1x9gknd 3128 1 Units unit NNS cord-010119-t1x9gknd 3128 2 underwent undergo VBD cord-010119-t1x9gknd 3128 3 red red JJ cord-010119-t1x9gknd 3128 4 cell cell NN cord-010119-t1x9gknd 3128 5 and and CC cord-010119-t1x9gknd 3128 6 plasma plasma NN cord-010119-t1x9gknd 3128 7 depletion depletion NN cord-010119-t1x9gknd 3128 8 and and CC cord-010119-t1x9gknd 3128 9 then then RB cord-010119-t1x9gknd 3128 10 subjected subject VBN cord-010119-t1x9gknd 3128 11 to to IN cord-010119-t1x9gknd 3128 12 controlled control VBN cord-010119-t1x9gknd 3128 13 rate rate NN cord-010119-t1x9gknd 3128 14 freezing freezing NN cord-010119-t1x9gknd 3128 15 and and CC cord-010119-t1x9gknd 3128 16 subsequent subsequent JJ cord-010119-t1x9gknd 3128 17 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3128 18 using use VBG cord-010119-t1x9gknd 3128 19 DMSO DMSO NNP cord-010119-t1x9gknd 3128 20 ( ( -LRB- cord-010119-t1x9gknd 3128 21 dimethylsulfoxide dimethylsulfoxide NN cord-010119-t1x9gknd 3128 22 ) ) -RRB- cord-010119-t1x9gknd 3128 23 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3128 24 with with IN cord-010119-t1x9gknd 3128 25 10 10 CD cord-010119-t1x9gknd 3128 26 % % NN cord-010119-t1x9gknd 3128 27 concentration concentration NN cord-010119-t1x9gknd 3128 28 . . . cord-010119-t1x9gknd 3129 1 Informed informed JJ cord-010119-t1x9gknd 3129 2 consent consent NN cord-010119-t1x9gknd 3129 3 and and CC cord-010119-t1x9gknd 3129 4 the the DT cord-010119-t1x9gknd 3129 5 unit unit NN cord-010119-t1x9gknd 3129 6 discard discard VBP cord-010119-t1x9gknd 3129 7 terms term NNS cord-010119-t1x9gknd 3129 8 for for IN cord-010119-t1x9gknd 3129 9 all all DT cord-010119-t1x9gknd 3129 10 units unit NNS cord-010119-t1x9gknd 3129 11 were be VBD cord-010119-t1x9gknd 3129 12 obtained obtain VBN cord-010119-t1x9gknd 3129 13 . . . cord-010119-t1x9gknd 3130 1 Units unit NNS cord-010119-t1x9gknd 3130 2 were be VBD cord-010119-t1x9gknd 3130 3 thawed thaw VBN cord-010119-t1x9gknd 3130 4 in in IN cord-010119-t1x9gknd 3130 5 a a DT cord-010119-t1x9gknd 3130 6 378 378 CD cord-010119-t1x9gknd 3130 7 C c NN cord-010119-t1x9gknd 3130 8 water water NN cord-010119-t1x9gknd 3130 9 bath bath NN cord-010119-t1x9gknd 3130 10 and and CC cord-010119-t1x9gknd 3130 11 0.5ml 0.5ml CD cord-010119-t1x9gknd 3130 12 aliquots aliquot NNS cord-010119-t1x9gknd 3130 13 were be VBD cord-010119-t1x9gknd 3130 14 diluted dilute VBN cord-010119-t1x9gknd 3130 15 at at IN cord-010119-t1x9gknd 3130 16 a a DT cord-010119-t1x9gknd 3130 17 1:1 1:1 CD cord-010119-t1x9gknd 3130 18 proportion proportion NN cord-010119-t1x9gknd 3130 19 with with IN cord-010119-t1x9gknd 3130 20 5 5 CD cord-010119-t1x9gknd 3130 21 % % NN cord-010119-t1x9gknd 3130 22 human human JJ cord-010119-t1x9gknd 3130 23 albumin albumin NN cord-010119-t1x9gknd 3130 24 solution solution NN cord-010119-t1x9gknd 3130 25 and and CC cord-010119-t1x9gknd 3130 26 plasmin plasmin NNP cord-010119-t1x9gknd 3130 27 were be VBD cord-010119-t1x9gknd 3130 28 prepared prepare VBN cord-010119-t1x9gknd 3130 29 , , , cord-010119-t1x9gknd 3130 30 enabling enable VBG cord-010119-t1x9gknd 3130 31 DMSO DMSO NNP cord-010119-t1x9gknd 3130 32 stabilization stabilization NN cord-010119-t1x9gknd 3130 33 and and CC cord-010119-t1x9gknd 3130 34 concentration concentration NN cord-010119-t1x9gknd 3130 35 reduction reduction NN cord-010119-t1x9gknd 3130 36 . . . cord-010119-t1x9gknd 3131 1 The the DT cord-010119-t1x9gknd 3131 2 following follow VBG cord-010119-t1x9gknd 3131 3 analysis analysis NN cord-010119-t1x9gknd 3131 4 were be VBD cord-010119-t1x9gknd 3131 5 performed perform VBN cord-010119-t1x9gknd 3131 6 : : : cord-010119-t1x9gknd 3131 7 nucleated nucleated JJ cord-010119-t1x9gknd 3131 8 cell cell NN cord-010119-t1x9gknd 3131 9 count count NN cord-010119-t1x9gknd 3131 10 ( ( -LRB- cord-010119-t1x9gknd 3131 11 TNC TNC NNP cord-010119-t1x9gknd 3131 12 ) ) -RRB- cord-010119-t1x9gknd 3131 13 in in IN cord-010119-t1x9gknd 3131 14 an an DT cord-010119-t1x9gknd 3131 15 automated automate VBN cord-010119-t1x9gknd 3131 16 hematologic hematologic JJ cord-010119-t1x9gknd 3131 17 counter counter NN cord-010119-t1x9gknd 3131 18 and and CC cord-010119-t1x9gknd 3131 19 cell cell NN cord-010119-t1x9gknd 3131 20 viability viability NN cord-010119-t1x9gknd 3131 21 using use VBG cord-010119-t1x9gknd 3131 22 flow flow NN cord-010119-t1x9gknd 3131 23 citometry citometry NNP cord-010119-t1x9gknd 3131 24 . . . cord-010119-t1x9gknd 3132 1 Post post JJ cord-010119-t1x9gknd 3132 2 - - JJ cord-010119-t1x9gknd 3132 3 processing processing JJ cord-010119-t1x9gknd 3132 4 ( ( -LRB- cord-010119-t1x9gknd 3132 5 pre pre JJ cord-010119-t1x9gknd 3132 6 - - JJ cord-010119-t1x9gknd 3132 7 cryopreservation cryopreservation JJ cord-010119-t1x9gknd 3132 8 ) ) -RRB- cord-010119-t1x9gknd 3132 9 cell cell NN cord-010119-t1x9gknd 3132 10 viability viability NN cord-010119-t1x9gknd 3132 11 was be VBD cord-010119-t1x9gknd 3132 12 tested test VBN cord-010119-t1x9gknd 3132 13 using use VBG cord-010119-t1x9gknd 3132 14 trypan trypan NNP cord-010119-t1x9gknd 3132 15 blue blue NNP cord-010119-t1x9gknd 3132 16 as as IN cord-010119-t1x9gknd 3132 17 exclusion exclusion NN cord-010119-t1x9gknd 3132 18 dye dye NN cord-010119-t1x9gknd 3132 19 , , , cord-010119-t1x9gknd 3132 20 while while IN cord-010119-t1x9gknd 3132 21 post post JJ cord-010119-t1x9gknd 3132 22 - - JJ cord-010119-t1x9gknd 3132 23 thaw thaw JJ cord-010119-t1x9gknd 3132 24 cell cell NN cord-010119-t1x9gknd 3132 25 viability viability NN cord-010119-t1x9gknd 3132 26 was be VBD cord-010119-t1x9gknd 3132 27 assessed assess VBN cord-010119-t1x9gknd 3132 28 using use VBG cord-010119-t1x9gknd 3132 29 7-AAD 7-aad CD cord-010119-t1x9gknd 3132 30 marker marker NN cord-010119-t1x9gknd 3132 31 through through IN cord-010119-t1x9gknd 3132 32 flow flow NN cord-010119-t1x9gknd 3132 33 cytometric cytometric NNP cord-010119-t1x9gknd 3132 34 analysis analysis NN cord-010119-t1x9gknd 3132 35 . . . cord-010119-t1x9gknd 3133 1 Results/ Results/ . cord-010119-t1x9gknd 3134 1 Finding finding NN cord-010119-t1x9gknd 3134 2 : : : cord-010119-t1x9gknd 3135 1 UCB UCB NNP cord-010119-t1x9gknd 3135 2 storage storage NN cord-010119-t1x9gknd 3135 3 period period NN cord-010119-t1x9gknd 3135 4 was be VBD cord-010119-t1x9gknd 3135 5 7.24 7.24 CD cord-010119-t1x9gknd 3135 6 years year NNS cord-010119-t1x9gknd 3135 7 ( ( -LRB- cord-010119-t1x9gknd 3135 8 mean mean UH cord-010119-t1x9gknd 3135 9 ) ) -RRB- cord-010119-t1x9gknd 3135 10 and and CC cord-010119-t1x9gknd 3135 11 cell cell NN cord-010119-t1x9gknd 3135 12 recovery recovery NN cord-010119-t1x9gknd 3135 13 was be VBD cord-010119-t1x9gknd 3135 14 86.31 86.31 CD cord-010119-t1x9gknd 3135 15 % % NN cord-010119-t1x9gknd 3135 16 ( ( -LRB- cord-010119-t1x9gknd 3135 17 mean mean VB cord-010119-t1x9gknd 3135 18 ) ) -RRB- cord-010119-t1x9gknd 3135 19 . . . cord-010119-t1x9gknd 3136 1 There there EX cord-010119-t1x9gknd 3136 2 was be VBD cord-010119-t1x9gknd 3136 3 no no DT cord-010119-t1x9gknd 3136 4 statistically statistically RB cord-010119-t1x9gknd 3136 5 significant significant JJ cord-010119-t1x9gknd 3136 6 correlation correlation NN cord-010119-t1x9gknd 3136 7 between between IN cord-010119-t1x9gknd 3136 8 storage storage NN cord-010119-t1x9gknd 3136 9 period period NN cord-010119-t1x9gknd 3136 10 and and CC cord-010119-t1x9gknd 3136 11 post post JJ cord-010119-t1x9gknd 3136 12 - - JJ cord-010119-t1x9gknd 3136 13 processing processing JJ cord-010119-t1x9gknd 3136 14 cell cell NN cord-010119-t1x9gknd 3136 15 recovery recovery NN cord-010119-t1x9gknd 3137 1 ( ( -LRB- cord-010119-t1x9gknd 3137 2 p p NN cord-010119-t1x9gknd 3137 3 5 5 CD cord-010119-t1x9gknd 3137 4 0.11 0.11 CD cord-010119-t1x9gknd 3137 5 ) ) -RRB- cord-010119-t1x9gknd 3137 6 . . . cord-010119-t1x9gknd 3138 1 Post post JJ cord-010119-t1x9gknd 3138 2 - - JJ cord-010119-t1x9gknd 3138 3 thaw thaw VB cord-010119-t1x9gknd 3138 4 cell cell NN cord-010119-t1x9gknd 3138 5 viability viability NN cord-010119-t1x9gknd 3138 6 of of IN cord-010119-t1x9gknd 3138 7 63.13 63.13 CD cord-010119-t1x9gknd 3138 8 % % NN cord-010119-t1x9gknd 3138 9 ( ( -LRB- cord-010119-t1x9gknd 3138 10 mean mean UH cord-010119-t1x9gknd 3138 11 ) ) -RRB- cord-010119-t1x9gknd 3138 12 showed show VBD cord-010119-t1x9gknd 3138 13 no no DT cord-010119-t1x9gknd 3138 14 statistically statistically RB cord-010119-t1x9gknd 3138 15 significant significant JJ cord-010119-t1x9gknd 3138 16 correlation correlation NN cord-010119-t1x9gknd 3138 17 with with IN cord-010119-t1x9gknd 3138 18 unit unit NN cord-010119-t1x9gknd 3138 19 storage storage NN cord-010119-t1x9gknd 3138 20 period period NN cord-010119-t1x9gknd 3138 21 ( ( -LRB- cord-010119-t1x9gknd 3138 22 p p NN cord-010119-t1x9gknd 3138 23 5 5 CD cord-010119-t1x9gknd 3138 24 0.07 0.07 CD cord-010119-t1x9gknd 3138 25 ) ) -RRB- cord-010119-t1x9gknd 3138 26 . . . cord-010119-t1x9gknd 3139 1 Post post NN cord-010119-t1x9gknd 3139 2 thaw thaw NN cord-010119-t1x9gknd 3139 3 cell cell NN cord-010119-t1x9gknd 3139 4 viability viability NN cord-010119-t1x9gknd 3139 5 results result NNS cord-010119-t1x9gknd 3139 6 are be VBP cord-010119-t1x9gknd 3139 7 within within IN cord-010119-t1x9gknd 3139 8 parameters parameter NNS cord-010119-t1x9gknd 3139 9 defined define VBN cord-010119-t1x9gknd 3139 10 in in IN cord-010119-t1x9gknd 3139 11 other other JJ cord-010119-t1x9gknd 3139 12 studies study NNS cord-010119-t1x9gknd 3139 13 . . . cord-010119-t1x9gknd 3140 1 Background Background NNP cord-010119-t1x9gknd 3140 2 / / SYM cord-010119-t1x9gknd 3140 3 Case Case NNP cord-010119-t1x9gknd 3140 4 Studies Studies NNPS cord-010119-t1x9gknd 3140 5 : : : cord-010119-t1x9gknd 3141 1 Umbilical umbilical JJ cord-010119-t1x9gknd 3141 2 cord cord NN cord-010119-t1x9gknd 3141 3 ( ( -LRB- cord-010119-t1x9gknd 3141 4 UC UC NNP cord-010119-t1x9gknd 3141 5 ) ) -RRB- cord-010119-t1x9gknd 3141 6 tissue tissue NN cord-010119-t1x9gknd 3141 7 is be VBZ cord-010119-t1x9gknd 3141 8 a a DT cord-010119-t1x9gknd 3141 9 rich rich JJ cord-010119-t1x9gknd 3141 10 source source NN cord-010119-t1x9gknd 3141 11 of of IN cord-010119-t1x9gknd 3141 12 mesenchymal mesenchymal JJ cord-010119-t1x9gknd 3141 13 stem stem NN cord-010119-t1x9gknd 3141 14 cells cell NNS cord-010119-t1x9gknd 3141 15 ( ( -LRB- cord-010119-t1x9gknd 3141 16 MSCs msc NNS cord-010119-t1x9gknd 3141 17 ) ) -RRB- cord-010119-t1x9gknd 3141 18 that that WDT cord-010119-t1x9gknd 3141 19 can can MD cord-010119-t1x9gknd 3141 20 be be VB cord-010119-t1x9gknd 3141 21 collected collect VBN cord-010119-t1x9gknd 3141 22 noninvasively noninvasively RB cord-010119-t1x9gknd 3141 23 at at IN cord-010119-t1x9gknd 3141 24 birth birth NN cord-010119-t1x9gknd 3141 25 and and CC cord-010119-t1x9gknd 3141 26 stored store VBN cord-010119-t1x9gknd 3141 27 for for IN cord-010119-t1x9gknd 3141 28 potential potential JJ cord-010119-t1x9gknd 3141 29 future future JJ cord-010119-t1x9gknd 3141 30 use use NN cord-010119-t1x9gknd 3141 31 . . . cord-010119-t1x9gknd 3142 1 As as IN cord-010119-t1x9gknd 3142 2 such such JJ cord-010119-t1x9gknd 3142 3 , , , cord-010119-t1x9gknd 3142 4 a a DT cord-010119-t1x9gknd 3142 5 growing grow VBG cord-010119-t1x9gknd 3142 6 number number NN cord-010119-t1x9gknd 3142 7 of of IN cord-010119-t1x9gknd 3142 8 stem stem NN cord-010119-t1x9gknd 3142 9 cell cell NN cord-010119-t1x9gknd 3142 10 banks bank NNS cord-010119-t1x9gknd 3142 11 have have VBP cord-010119-t1x9gknd 3142 12 established establish VBN cord-010119-t1x9gknd 3142 13 UC UC NNP cord-010119-t1x9gknd 3142 14 storage storage NN cord-010119-t1x9gknd 3142 15 programs program NNS cord-010119-t1x9gknd 3142 16 based base VBN cord-010119-t1x9gknd 3142 17 on on IN cord-010119-t1x9gknd 3142 18 mounting mount VBG cord-010119-t1x9gknd 3142 19 preclinical preclinical JJ cord-010119-t1x9gknd 3142 20 evidence evidence NN cord-010119-t1x9gknd 3142 21 of of IN cord-010119-t1x9gknd 3142 22 its -PRON- PRP$ cord-010119-t1x9gknd 3142 23 therapeutic therapeutic JJ cord-010119-t1x9gknd 3142 24 potential potential NN cord-010119-t1x9gknd 3142 25 . . . cord-010119-t1x9gknd 3143 1 However however RB cord-010119-t1x9gknd 3143 2 , , , cord-010119-t1x9gknd 3143 3 little little JJ cord-010119-t1x9gknd 3143 4 has have VBZ cord-010119-t1x9gknd 3143 5 been be VBN cord-010119-t1x9gknd 3143 6 reported report VBN cord-010119-t1x9gknd 3143 7 on on IN cord-010119-t1x9gknd 3143 8 the the DT cord-010119-t1x9gknd 3143 9 ability ability NN cord-010119-t1x9gknd 3143 10 to to TO cord-010119-t1x9gknd 3143 11 isolate isolate VB cord-010119-t1x9gknd 3143 12 MSC MSC NNP cord-010119-t1x9gknd 3143 13 - - HYPH cord-010119-t1x9gknd 3143 14 like like JJ cord-010119-t1x9gknd 3143 15 cells cell NNS cord-010119-t1x9gknd 3143 16 from from IN cord-010119-t1x9gknd 3143 17 UC UC NNP cord-010119-t1x9gknd 3143 18 tissue tissue NN cord-010119-t1x9gknd 3143 19 after after IN cord-010119-t1x9gknd 3143 20 extended extended JJ cord-010119-t1x9gknd 3143 21 periods period NNS cord-010119-t1x9gknd 3143 22 of of IN cord-010119-t1x9gknd 3143 23 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3143 24 . . . cord-010119-t1x9gknd 3144 1 This this DT cord-010119-t1x9gknd 3144 2 work work NN cord-010119-t1x9gknd 3144 3 describes describe VBZ cord-010119-t1x9gknd 3144 4 and and CC cord-010119-t1x9gknd 3144 5 characterizes characterize VBZ cord-010119-t1x9gknd 3144 6 the the DT cord-010119-t1x9gknd 3144 7 isolation isolation NN cord-010119-t1x9gknd 3144 8 of of IN cord-010119-t1x9gknd 3144 9 MSCs msc NNS cord-010119-t1x9gknd 3144 10 from from IN cord-010119-t1x9gknd 3144 11 UC UC NNP cord-010119-t1x9gknd 3144 12 tissue tissue NN cord-010119-t1x9gknd 3144 13 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3144 14 as as IN cord-010119-t1x9gknd 3144 15 a a DT cord-010119-t1x9gknd 3144 16 composite composite JJ cord-010119-t1x9gknd 3144 17 material material NN cord-010119-t1x9gknd 3144 18 at at IN cord-010119-t1x9gknd 3144 19 a a DT cord-010119-t1x9gknd 3144 20 family family NN cord-010119-t1x9gknd 3144 21 stem stem NN cord-010119-t1x9gknd 3144 22 cell cell NN cord-010119-t1x9gknd 3144 23 bank bank NN cord-010119-t1x9gknd 3144 24 for for IN cord-010119-t1x9gknd 3144 25 5 5 CD cord-010119-t1x9gknd 3144 26 years year NNS cord-010119-t1x9gknd 3144 27 . . . cord-010119-t1x9gknd 3145 1 Study Study NNP cord-010119-t1x9gknd 3145 2 Design Design NNP cord-010119-t1x9gknd 3145 3 / / SYM cord-010119-t1x9gknd 3145 4 Method method NN cord-010119-t1x9gknd 3145 5 : : : cord-010119-t1x9gknd 3145 6 Donated donate VBN cord-010119-t1x9gknd 3145 7 UC UC NNP cord-010119-t1x9gknd 3145 8 units unit NNS cord-010119-t1x9gknd 3145 9 from from IN cord-010119-t1x9gknd 3145 10 consenting consent VBG cord-010119-t1x9gknd 3145 11 mothers mother NNS cord-010119-t1x9gknd 3145 12 were be VBD cord-010119-t1x9gknd 3145 13 evaluated evaluate VBN cord-010119-t1x9gknd 3145 14 . . . cord-010119-t1x9gknd 3146 1 Units unit NNS cord-010119-t1x9gknd 3146 2 had have VBD cord-010119-t1x9gknd 3146 3 been be VBN cord-010119-t1x9gknd 3146 4 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3146 5 as as IN cord-010119-t1x9gknd 3146 6 composite composite JJ cord-010119-t1x9gknd 3146 7 tissue tissue NN cord-010119-t1x9gknd 3146 8 pieces piece NNS cord-010119-t1x9gknd 3146 9 in in IN cord-010119-t1x9gknd 3146 10 LN ln NN cord-010119-t1x9gknd 3146 11 2 2 CD cord-010119-t1x9gknd 3146 12 vapor vapor NN cord-010119-t1x9gknd 3146 13 in in IN cord-010119-t1x9gknd 3146 14 a a DT cord-010119-t1x9gknd 3146 15 DMSO DMSO NNP cord-010119-t1x9gknd 3146 16 - - HYPH cord-010119-t1x9gknd 3146 17 based base VBN cord-010119-t1x9gknd 3146 18 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3146 19 for for IN cord-010119-t1x9gknd 3146 20 5yrs 5yrs CD cord-010119-t1x9gknd 3146 21 . . . cord-010119-t1x9gknd 3147 1 ( ( -LRB- cord-010119-t1x9gknd 3147 2 5.49 5.49 CD cord-010119-t1x9gknd 3147 3 6 6 CD cord-010119-t1x9gknd 3147 4 0.431 0.431 CD cord-010119-t1x9gknd 3147 5 ; ; : cord-010119-t1x9gknd 3147 6 n54 n54 CD cord-010119-t1x9gknd 3147 7 ) ) -RRB- cord-010119-t1x9gknd 3147 8 . . . cord-010119-t1x9gknd 3148 1 Units unit NNS cord-010119-t1x9gknd 3148 2 were be VBD cord-010119-t1x9gknd 3148 3 rapidly rapidly RB cord-010119-t1x9gknd 3148 4 thawed thaw VBN cord-010119-t1x9gknd 3148 5 and and CC cord-010119-t1x9gknd 3148 6 rinsed rinse VBN cord-010119-t1x9gknd 3148 7 in in IN cord-010119-t1x9gknd 3148 8 DPBS DPBS NNP cord-010119-t1x9gknd 3148 9 , , , cord-010119-t1x9gknd 3148 10 then then RB cord-010119-t1x9gknd 3148 11 25 25 CD cord-010119-t1x9gknd 3148 12 pieces piece NNS cord-010119-t1x9gknd 3148 13 were be VBD cord-010119-t1x9gknd 3148 14 excised excise VBN cord-010119-t1x9gknd 3148 15 from from IN cord-010119-t1x9gknd 3148 16 each each DT cord-010119-t1x9gknd 3148 17 using use VBG cord-010119-t1x9gknd 3148 18 a a DT cord-010119-t1x9gknd 3148 19 biopsy biopsy JJ cord-010119-t1x9gknd 3148 20 punch punch NN cord-010119-t1x9gknd 3148 21 . . . cord-010119-t1x9gknd 3149 1 Pieces piece NNS cord-010119-t1x9gknd 3149 2 from from IN cord-010119-t1x9gknd 3149 3 each each DT cord-010119-t1x9gknd 3149 4 unit unit NN cord-010119-t1x9gknd 3149 5 were be VBD cord-010119-t1x9gknd 3149 6 explanted explante VBN cord-010119-t1x9gknd 3149 7 in in IN cord-010119-t1x9gknd 3149 8 a a DT cord-010119-t1x9gknd 3149 9 5x5 5x5 CD cord-010119-t1x9gknd 3149 10 grid grid NN cord-010119-t1x9gknd 3149 11 pattern pattern NN cord-010119-t1x9gknd 3149 12 in in IN cord-010119-t1x9gknd 3149 13 MSC MSC NNP cord-010119-t1x9gknd 3149 14 - - HYPH cord-010119-t1x9gknd 3149 15 supportive supportive JJ cord-010119-t1x9gknd 3149 16 medium medium NN cord-010119-t1x9gknd 3149 17 and and CC cord-010119-t1x9gknd 3149 18 incubated incubate VBN cord-010119-t1x9gknd 3149 19 for for IN cord-010119-t1x9gknd 3149 20 7 7 CD cord-010119-t1x9gknd 3149 21 days day NNS cord-010119-t1x9gknd 3149 22 , , , cord-010119-t1x9gknd 3149 23 after after IN cord-010119-t1x9gknd 3149 24 which which WDT cord-010119-t1x9gknd 3149 25 the the DT cord-010119-t1x9gknd 3149 26 tissue tissue NN cord-010119-t1x9gknd 3149 27 was be VBD cord-010119-t1x9gknd 3149 28 discarded discard VBN cord-010119-t1x9gknd 3149 29 and and CC cord-010119-t1x9gknd 3149 30 media medium NNS cord-010119-t1x9gknd 3149 31 exchanged exchange VBD cord-010119-t1x9gknd 3149 32 . . . cord-010119-t1x9gknd 3150 1 Cells cell NNS cord-010119-t1x9gknd 3150 2 were be VBD cord-010119-t1x9gknd 3150 3 isolated isolate VBN cord-010119-t1x9gknd 3150 4 on on IN cord-010119-t1x9gknd 3150 5 the the DT cord-010119-t1x9gknd 3150 6 14 14 CD cord-010119-t1x9gknd 3150 7 th th CD cord-010119-t1x9gknd 3150 8 day day NN cord-010119-t1x9gknd 3150 9 , , , cord-010119-t1x9gknd 3150 10 counted count VBN cord-010119-t1x9gknd 3150 11 , , , cord-010119-t1x9gknd 3150 12 and and CC cord-010119-t1x9gknd 3150 13 subcultured subculture VBD cord-010119-t1x9gknd 3150 14 for for IN cord-010119-t1x9gknd 3150 15 two two CD cord-010119-t1x9gknd 3150 16 passages passage NNS cord-010119-t1x9gknd 3150 17 . . . cord-010119-t1x9gknd 3151 1 At at IN cord-010119-t1x9gknd 3151 2 the the DT cord-010119-t1x9gknd 3151 3 end end NN cord-010119-t1x9gknd 3151 4 of of IN cord-010119-t1x9gknd 3151 5 each each DT cord-010119-t1x9gknd 3151 6 passage passage NN cord-010119-t1x9gknd 3151 7 , , , cord-010119-t1x9gknd 3151 8 cells cell NNS cord-010119-t1x9gknd 3151 9 were be VBD cord-010119-t1x9gknd 3151 10 collected collect VBN cord-010119-t1x9gknd 3151 11 , , , cord-010119-t1x9gknd 3151 12 counted count VBN cord-010119-t1x9gknd 3151 13 and and CC cord-010119-t1x9gknd 3151 14 population population NN cord-010119-t1x9gknd 3151 15 doubling double VBG cord-010119-t1x9gknd 3151 16 time time NN cord-010119-t1x9gknd 3151 17 was be VBD cord-010119-t1x9gknd 3151 18 calculated calculate VBN cord-010119-t1x9gknd 3151 19 . . . cord-010119-t1x9gknd 3152 1 Isolated isolated JJ cord-010119-t1x9gknd 3152 2 cells cell NNS cord-010119-t1x9gknd 3152 3 from from IN cord-010119-t1x9gknd 3152 4 each each DT cord-010119-t1x9gknd 3152 5 unit unit NN cord-010119-t1x9gknd 3152 6 were be VBD cord-010119-t1x9gknd 3152 7 also also RB cord-010119-t1x9gknd 3152 8 evaluated evaluate VBN cord-010119-t1x9gknd 3152 9 for for IN cord-010119-t1x9gknd 3152 10 MSC MSC NNP cord-010119-t1x9gknd 3152 11 immunomarkers immunomarker NNS cord-010119-t1x9gknd 3152 12 . . . cord-010119-t1x9gknd 3153 1 Results/ Results/ . cord-010119-t1x9gknd 3154 1 Finding finding NN cord-010119-t1x9gknd 3154 2 : : : cord-010119-t1x9gknd 3155 1 Small small JJ cord-010119-t1x9gknd 3155 2 , , , cord-010119-t1x9gknd 3155 3 proliferative proliferative JJ cord-010119-t1x9gknd 3155 4 cells cell NNS cord-010119-t1x9gknd 3155 5 with with IN cord-010119-t1x9gknd 3155 6 fibroblastic fibroblastic JJ cord-010119-t1x9gknd 3155 7 morphology morphology NN cord-010119-t1x9gknd 3155 8 were be VBD cord-010119-t1x9gknd 3155 9 obtained obtain VBN cord-010119-t1x9gknd 3155 10 from from IN cord-010119-t1x9gknd 3155 11 all all DT cord-010119-t1x9gknd 3155 12 explants explant NNS cord-010119-t1x9gknd 3155 13 , , , cord-010119-t1x9gknd 3155 14 yielding yield VBG cord-010119-t1x9gknd 3155 15 a a DT cord-010119-t1x9gknd 3155 16 100 100 CD cord-010119-t1x9gknd 3155 17 % % NN cord-010119-t1x9gknd 3155 18 success success NN cord-010119-t1x9gknd 3155 19 rate rate NN cord-010119-t1x9gknd 3155 20 . . . cord-010119-t1x9gknd 3156 1 Cells cell NNS cord-010119-t1x9gknd 3156 2 were be VBD cord-010119-t1x9gknd 3156 3 positive positive JJ cord-010119-t1x9gknd 3156 4 for for IN cord-010119-t1x9gknd 3156 5 the the DT cord-010119-t1x9gknd 3156 6 MSC MSC NNP cord-010119-t1x9gknd 3156 7 markers marker NNS cord-010119-t1x9gknd 3156 8 CD73 CD73 NNP cord-010119-t1x9gknd 3156 9 , , , cord-010119-t1x9gknd 3156 10 CD90 CD90 NNP cord-010119-t1x9gknd 3156 11 , , , cord-010119-t1x9gknd 3156 12 and and CC cord-010119-t1x9gknd 3156 13 CD105 CD105 NNP cord-010119-t1x9gknd 3156 14 ( ( -LRB- cord-010119-t1x9gknd 3156 15 98.8 98.8 CD cord-010119-t1x9gknd 3156 16 6 6 CD cord-010119-t1x9gknd 3156 17 0.7 0.7 CD cord-010119-t1x9gknd 3156 18 % % NN cord-010119-t1x9gknd 3156 19 , , , cord-010119-t1x9gknd 3156 20 98.7 98.7 CD cord-010119-t1x9gknd 3156 21 6 6 CD cord-010119-t1x9gknd 3156 22 0.6 0.6 CD cord-010119-t1x9gknd 3156 23 % % NN cord-010119-t1x9gknd 3156 24 , , , cord-010119-t1x9gknd 3156 25 and and CC cord-010119-t1x9gknd 3156 26 97.8 97.8 CD cord-010119-t1x9gknd 3156 27 6 6 CD cord-010119-t1x9gknd 3156 28 0.6 0.6 CD cord-010119-t1x9gknd 3156 29 % % NN cord-010119-t1x9gknd 3156 30 , , , cord-010119-t1x9gknd 3156 31 respectively respectively RB cord-010119-t1x9gknd 3156 32 ) ) -RRB- cord-010119-t1x9gknd 3156 33 and and CC cord-010119-t1x9gknd 3156 34 negative negative JJ cord-010119-t1x9gknd 3156 35 for for IN cord-010119-t1x9gknd 3156 36 the the DT cord-010119-t1x9gknd 3156 37 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 3156 38 markers marker NNS cord-010119-t1x9gknd 3156 39 CD34/45 cd34/45 CD cord-010119-t1x9gknd 3156 40 ( ( -LRB- cord-010119-t1x9gknd 3156 41 1.1 1.1 CD cord-010119-t1x9gknd 3156 42 6 6 CD cord-010119-t1x9gknd 3156 43 0.7 0.7 CD cord-010119-t1x9gknd 3156 44 % % NN cord-010119-t1x9gknd 3156 45 ) ) -RRB- cord-010119-t1x9gknd 3156 46 . . . cord-010119-t1x9gknd 3157 1 Passage passage NN cord-010119-t1x9gknd 3157 2 1 1 CD cord-010119-t1x9gknd 3157 3 and and CC cord-010119-t1x9gknd 3157 4 passage passage NN cord-010119-t1x9gknd 3157 5 2 2 CD cord-010119-t1x9gknd 3157 6 doubling double VBG cord-010119-t1x9gknd 3157 7 times time NNS cord-010119-t1x9gknd 3157 8 were be VBD cord-010119-t1x9gknd 3157 9 1.92 1.92 CD cord-010119-t1x9gknd 3157 10 6 6 CD cord-010119-t1x9gknd 3157 11 0.47 0.47 CD cord-010119-t1x9gknd 3157 12 days day NNS cord-010119-t1x9gknd 3157 13 and and CC cord-010119-t1x9gknd 3157 14 2.07 2.07 CD cord-010119-t1x9gknd 3157 15 6 6 CD cord-010119-t1x9gknd 3157 16 0.43 0.43 CD cord-010119-t1x9gknd 3157 17 days day NNS cord-010119-t1x9gknd 3157 18 , , , cord-010119-t1x9gknd 3157 19 respectively respectively RB cord-010119-t1x9gknd 3157 20 , , , cord-010119-t1x9gknd 3157 21 which which WDT cord-010119-t1x9gknd 3157 22 are be VBP cord-010119-t1x9gknd 3157 23 in in IN cord-010119-t1x9gknd 3157 24 line line NN cord-010119-t1x9gknd 3157 25 with with IN cord-010119-t1x9gknd 3157 26 values value NNS cord-010119-t1x9gknd 3157 27 reported report VBN cord-010119-t1x9gknd 3157 28 for for IN cord-010119-t1x9gknd 3157 29 MSCs msc NNS cord-010119-t1x9gknd 3157 30 isolated isolate VBN cord-010119-t1x9gknd 3157 31 from from IN cord-010119-t1x9gknd 3157 32 fresh fresh JJ cord-010119-t1x9gknd 3157 33 UC UC NNP cord-010119-t1x9gknd 3157 34 tissue tissue NN cord-010119-t1x9gknd 3157 35 . . . cord-010119-t1x9gknd 3158 1 Conclusion conclusion NN cord-010119-t1x9gknd 3158 2 : : : cord-010119-t1x9gknd 3158 3 Due due IN cord-010119-t1x9gknd 3158 4 to to IN cord-010119-t1x9gknd 3158 5 their -PRON- PRP$ cord-010119-t1x9gknd 3158 6 immature immature JJ cord-010119-t1x9gknd 3158 7 status status NN cord-010119-t1x9gknd 3158 8 , , , cord-010119-t1x9gknd 3158 9 ease ease NN cord-010119-t1x9gknd 3158 10 of of IN cord-010119-t1x9gknd 3158 11 collection collection NN cord-010119-t1x9gknd 3158 12 , , , cord-010119-t1x9gknd 3158 13 and and CC cord-010119-t1x9gknd 3158 14 potential potential JJ cord-010119-t1x9gknd 3158 15 therapeutic therapeutic JJ cord-010119-t1x9gknd 3158 16 value value NN cord-010119-t1x9gknd 3158 17 , , , cord-010119-t1x9gknd 3158 18 UC UC NNP cord-010119-t1x9gknd 3158 19 MSCs msc NNS cord-010119-t1x9gknd 3158 20 are be VBP cord-010119-t1x9gknd 3158 21 an an DT cord-010119-t1x9gknd 3158 22 appealing appeal VBG cord-010119-t1x9gknd 3158 23 candidate candidate NN cord-010119-t1x9gknd 3158 24 for for IN cord-010119-t1x9gknd 3158 25 future future JJ cord-010119-t1x9gknd 3158 26 clinical clinical JJ cord-010119-t1x9gknd 3158 27 75A 75a CD cord-010119-t1x9gknd 3158 28 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 3158 29 2017 2017 CD cord-010119-t1x9gknd 3158 30 Vol Vol NNP cord-010119-t1x9gknd 3158 31 . . . cord-010119-t1x9gknd 3159 1 57 57 CD cord-010119-t1x9gknd 3159 2 Supplement Supplement NNP cord-010119-t1x9gknd 3159 3 S3 S3 NNP cord-010119-t1x9gknd 3159 4 research research NN cord-010119-t1x9gknd 3159 5 and and CC cord-010119-t1x9gknd 3159 6 treatment treatment NN cord-010119-t1x9gknd 3159 7 . . . cord-010119-t1x9gknd 3160 1 The the DT cord-010119-t1x9gknd 3160 2 present present JJ cord-010119-t1x9gknd 3160 3 work work NN cord-010119-t1x9gknd 3160 4 demonstrates demonstrate VBZ cord-010119-t1x9gknd 3160 5 that that IN cord-010119-t1x9gknd 3160 6 the the DT cord-010119-t1x9gknd 3160 7 long long JJ cord-010119-t1x9gknd 3160 8 - - HYPH cord-010119-t1x9gknd 3160 9 term term NN cord-010119-t1x9gknd 3160 10 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3160 11 of of IN cord-010119-t1x9gknd 3160 12 UC UC NNP cord-010119-t1x9gknd 3160 13 tissue tissue NN cord-010119-t1x9gknd 3160 14 does do VBZ cord-010119-t1x9gknd 3160 15 not not RB cord-010119-t1x9gknd 3160 16 disrupt disrupt VB cord-010119-t1x9gknd 3160 17 the the DT cord-010119-t1x9gknd 3160 18 ability ability NN cord-010119-t1x9gknd 3160 19 to to TO cord-010119-t1x9gknd 3160 20 isolate isolate VB cord-010119-t1x9gknd 3160 21 functional functional JJ cord-010119-t1x9gknd 3160 22 MSCs msc NNS cord-010119-t1x9gknd 3160 23 from from IN cord-010119-t1x9gknd 3160 24 the the DT cord-010119-t1x9gknd 3160 25 tissue tissue NN cord-010119-t1x9gknd 3160 26 at at IN cord-010119-t1x9gknd 3160 27 a a DT cord-010119-t1x9gknd 3160 28 later later JJ cord-010119-t1x9gknd 3160 29 date date NN cord-010119-t1x9gknd 3160 30 . . . cord-010119-t1x9gknd 3161 1 Importantly importantly RB cord-010119-t1x9gknd 3161 2 , , , cord-010119-t1x9gknd 3161 3 growth growth NN cord-010119-t1x9gknd 3161 4 characteristics characteristic NNS cord-010119-t1x9gknd 3161 5 of of IN cord-010119-t1x9gknd 3161 6 isolated isolate VBN cord-010119-t1x9gknd 3161 7 MSCs msc NNS cord-010119-t1x9gknd 3161 8 appear appear VBP cord-010119-t1x9gknd 3161 9 to to TO cord-010119-t1x9gknd 3161 10 be be VB cord-010119-t1x9gknd 3161 11 comparable comparable JJ cord-010119-t1x9gknd 3161 12 to to IN cord-010119-t1x9gknd 3161 13 those those DT cord-010119-t1x9gknd 3161 14 reported report VBN cord-010119-t1x9gknd 3161 15 for for IN cord-010119-t1x9gknd 3161 16 MSCs msc NNS cord-010119-t1x9gknd 3161 17 from from IN cord-010119-t1x9gknd 3161 18 fresh fresh JJ cord-010119-t1x9gknd 3161 19 UC UC NNP cord-010119-t1x9gknd 3161 20 tissue tissue NN cord-010119-t1x9gknd 3161 21 . . . cord-010119-t1x9gknd 3162 1 Based base VBN cord-010119-t1x9gknd 3162 2 on on IN cord-010119-t1x9gknd 3162 3 the the DT cord-010119-t1x9gknd 3162 4 consistent consistent JJ cord-010119-t1x9gknd 3162 5 isolation isolation NN cord-010119-t1x9gknd 3162 6 and and CC cord-010119-t1x9gknd 3162 7 lack lack NN cord-010119-t1x9gknd 3162 8 of of IN cord-010119-t1x9gknd 3162 9 apparent apparent JJ cord-010119-t1x9gknd 3162 10 impact impact NN cord-010119-t1x9gknd 3162 11 on on IN cord-010119-t1x9gknd 3162 12 proliferation proliferation NN cord-010119-t1x9gknd 3162 13 kinetics kinetic NNS cord-010119-t1x9gknd 3162 14 , , , cord-010119-t1x9gknd 3162 15 it -PRON- PRP cord-010119-t1x9gknd 3162 16 is be VBZ cord-010119-t1x9gknd 3162 17 reasonable reasonable JJ cord-010119-t1x9gknd 3162 18 to to TO cord-010119-t1x9gknd 3162 19 expect expect VB cord-010119-t1x9gknd 3162 20 cell cell NN cord-010119-t1x9gknd 3162 21 yields yield NNS cord-010119-t1x9gknd 3162 22 in in IN cord-010119-t1x9gknd 3162 23 the the DT cord-010119-t1x9gknd 3162 24 range range NN cord-010119-t1x9gknd 3162 25 anticipated anticipate VBN cord-010119-t1x9gknd 3162 26 for for IN cord-010119-t1x9gknd 3162 27 therapeutic therapeutic JJ cord-010119-t1x9gknd 3162 28 requirements requirement NNS cord-010119-t1x9gknd 3162 29 and and CC cord-010119-t1x9gknd 3162 30 more more JJR cord-010119-t1x9gknd 3162 31 than than IN cord-010119-t1x9gknd 3162 32 sufficient sufficient JJ cord-010119-t1x9gknd 3162 33 for for IN cord-010119-t1x9gknd 3162 34 moving move VBG cord-010119-t1x9gknd 3162 35 to to IN cord-010119-t1x9gknd 3162 36 clinical clinical JJ cord-010119-t1x9gknd 3162 37 grade grade NN cord-010119-t1x9gknd 3162 38 bioreactors bioreactor NNS cord-010119-t1x9gknd 3162 39 for for IN cord-010119-t1x9gknd 3162 40 expansion expansion NN cord-010119-t1x9gknd 3162 41 . . . cord-010119-t1x9gknd 3163 1 These these DT cord-010119-t1x9gknd 3163 2 results result NNS cord-010119-t1x9gknd 3163 3 support support VBP cord-010119-t1x9gknd 3163 4 the the DT cord-010119-t1x9gknd 3163 5 feasibility feasibility NN cord-010119-t1x9gknd 3163 6 of of IN cord-010119-t1x9gknd 3163 7 storage storage NN cord-010119-t1x9gknd 3163 8 of of IN cord-010119-t1x9gknd 3163 9 UC UC NNP cord-010119-t1x9gknd 3163 10 as as IN cord-010119-t1x9gknd 3163 11 a a DT cord-010119-t1x9gknd 3163 12 composite composite JJ cord-010119-t1x9gknd 3163 13 material material NN cord-010119-t1x9gknd 3163 14 for for IN cord-010119-t1x9gknd 3163 15 future future JJ cord-010119-t1x9gknd 3163 16 potential potential JJ cord-010119-t1x9gknd 3163 17 cell cell NN cord-010119-t1x9gknd 3163 18 isolation isolation NN cord-010119-t1x9gknd 3163 19 and and CC cord-010119-t1x9gknd 3163 20 expansion expansion NN cord-010119-t1x9gknd 3163 21 to to IN cord-010119-t1x9gknd 3163 22 clinically clinically RB cord-010119-t1x9gknd 3163 23 relevant relevant JJ cord-010119-t1x9gknd 3163 24 doses dose NNS cord-010119-t1x9gknd 3163 25 . . . cord-010119-t1x9gknd 3164 1 Large large JJ cord-010119-t1x9gknd 3164 2 Volume Volume NNP cord-010119-t1x9gknd 3164 3 Leukapheresis Leukapheresis NNP cord-010119-t1x9gknd 3164 4 with with IN cord-010119-t1x9gknd 3164 5 Spectra Spectra NNP cord-010119-t1x9gknd 3164 6 Optia Optia NNP cord-010119-t1x9gknd 3164 7 Cmnc Cmnc NNP cord-010119-t1x9gknd 3164 8 Protocol Protocol NNP cord-010119-t1x9gknd 3164 9 in in IN cord-010119-t1x9gknd 3164 10 Adult Adult NNP cord-010119-t1x9gknd 3164 11 and and CC cord-010119-t1x9gknd 3164 12 Pediatric Pediatric NNP cord-010119-t1x9gknd 3164 13 Patients Patients NNPS cord-010119-t1x9gknd 3164 14 : : : cord-010119-t1x9gknd 3165 1 Performance performance NN cord-010119-t1x9gknd 3165 2 and and CC cord-010119-t1x9gknd 3165 3 Determination Determination NNP cord-010119-t1x9gknd 3165 4 of of IN cord-010119-t1x9gknd 3165 5 CD34 CD34 NNP cord-010119-t1x9gknd 3165 6 Yield Yield NNP cord-010119-t1x9gknd 3165 7 Prediction Prediction NNP cord-010119-t1x9gknd 3165 8 Algorithm Algorithm NNP cord-010119-t1x9gknd 3165 9 Ines Ines NNP cord-010119-t1x9gknd 3165 10 Bojanic Bojanic NNP cord-010119-t1x9gknd 3165 11 * * NFP cord-010119-t1x9gknd 3166 1 1 1 LS cord-010119-t1x9gknd 3166 2 , , , cord-010119-t1x9gknd 3166 3 Nelly Nelly NNP cord-010119-t1x9gknd 3166 4 Besson Besson NNP cord-010119-t1x9gknd 3166 5 2 2 CD cord-010119-t1x9gknd 3166 6 , , , cord-010119-t1x9gknd 3166 7 Ivana Ivana NNP cord-010119-t1x9gknd 3166 8 Vidovic Vidovic NNP cord-010119-t1x9gknd 3166 9 1 1 CD cord-010119-t1x9gknd 3166 10 and and CC cord-010119-t1x9gknd 3166 11 Branka Branka NNP cord-010119-t1x9gknd 3166 12 Golubic Golubic NNP cord-010119-t1x9gknd 3166 13 Cepulic Cepulic NNP cord-010119-t1x9gknd 3166 14 1 1 CD cord-010119-t1x9gknd 3166 15 . . . cord-010119-t1x9gknd 3167 1 1 1 LS cord-010119-t1x9gknd 3167 2 Department Department NNP cord-010119-t1x9gknd 3167 3 of of IN cord-010119-t1x9gknd 3167 4 Transfusion Transfusion NNP cord-010119-t1x9gknd 3167 5 Medicine Medicine NNP cord-010119-t1x9gknd 3167 6 and and CC cord-010119-t1x9gknd 3167 7 Transplantation Transplantation NNP cord-010119-t1x9gknd 3167 8 Biology Biology NNP cord-010119-t1x9gknd 3167 9 , , , cord-010119-t1x9gknd 3167 10 University University NNP cord-010119-t1x9gknd 3167 11 Hospital Hospital NNP cord-010119-t1x9gknd 3167 12 Centre Centre NNP cord-010119-t1x9gknd 3167 13 Zagreb Zagreb NNP cord-010119-t1x9gknd 3167 14 , , , cord-010119-t1x9gknd 3167 15 2 2 CD cord-010119-t1x9gknd 3167 16 Terumo Terumo NNP cord-010119-t1x9gknd 3167 17 BCT BCT NNP cord-010119-t1x9gknd 3167 18 Background Background NNP cord-010119-t1x9gknd 3167 19 / / SYM cord-010119-t1x9gknd 3167 20 Case Case NNP cord-010119-t1x9gknd 3167 21 Studies Studies NNPS cord-010119-t1x9gknd 3167 22 : : : cord-010119-t1x9gknd 3167 23 Large large JJ cord-010119-t1x9gknd 3167 24 volume volume NN cord-010119-t1x9gknd 3167 25 leukapheresis leukapheresis NN cord-010119-t1x9gknd 3167 26 ( ( -LRB- cord-010119-t1x9gknd 3167 27 LVL LVL NNP cord-010119-t1x9gknd 3167 28 ) ) -RRB- cord-010119-t1x9gknd 3167 29 have have VBP cord-010119-t1x9gknd 3167 30 shown show VBN cord-010119-t1x9gknd 3167 31 to to TO cord-010119-t1x9gknd 3167 32 enhance enhance VB cord-010119-t1x9gknd 3167 33 CD341cell CD341cell NNP cord-010119-t1x9gknd 3167 34 yield yield NN cord-010119-t1x9gknd 3167 35 collected collect VBN cord-010119-t1x9gknd 3167 36 . . . cord-010119-t1x9gknd 3168 1 This this DT cord-010119-t1x9gknd 3168 2 study study NN cord-010119-t1x9gknd 3168 3 evaluated evaluate VBD cord-010119-t1x9gknd 3168 4 performance performance NN cord-010119-t1x9gknd 3168 5 and and CC cord-010119-t1x9gknd 3168 6 safety safety NN cord-010119-t1x9gknd 3168 7 of of IN cord-010119-t1x9gknd 3168 8 the the DT cord-010119-t1x9gknd 3168 9 Spectra Spectra NNP cord-010119-t1x9gknd 3168 10 Optia Optia NNP cord-010119-t1x9gknd 3168 11 CMNC CMNC NNP cord-010119-t1x9gknd 3168 12 protocol protocol NN cord-010119-t1x9gknd 3168 13 ( ( -LRB- cord-010119-t1x9gknd 3168 14 version version NN cord-010119-t1x9gknd 3168 15 11 11 CD cord-010119-t1x9gknd 3168 16 ) ) -RRB- cord-010119-t1x9gknd 3168 17 in in IN cord-010119-t1x9gknd 3168 18 adult adult NN cord-010119-t1x9gknd 3168 19 and and CC cord-010119-t1x9gknd 3168 20 pediatric pediatric JJ cord-010119-t1x9gknd 3168 21 LVL lvl NN cord-010119-t1x9gknd 3168 22 . . . cord-010119-t1x9gknd 3169 1 A a DT cord-010119-t1x9gknd 3169 2 prediction prediction NN cord-010119-t1x9gknd 3169 3 algorithm algorithm NN cord-010119-t1x9gknd 3169 4 for for IN cord-010119-t1x9gknd 3169 5 CD341cell CD341cell NNP cord-010119-t1x9gknd 3169 6 yield yield NN cord-010119-t1x9gknd 3169 7 was be VBD cord-010119-t1x9gknd 3169 8 also also RB cord-010119-t1x9gknd 3169 9 tested test VBN cord-010119-t1x9gknd 3169 10 . . . cord-010119-t1x9gknd 3170 1 Study Study NNP cord-010119-t1x9gknd 3170 2 Design Design NNP cord-010119-t1x9gknd 3170 3 / / SYM cord-010119-t1x9gknd 3170 4 Method method NN cord-010119-t1x9gknd 3170 5 : : : cord-010119-t1x9gknd 3171 1 We -PRON- PRP cord-010119-t1x9gknd 3171 2 evaluated evaluate VBD cord-010119-t1x9gknd 3171 3 retrospectively retrospectively RB cord-010119-t1x9gknd 3171 4 67 67 CD cord-010119-t1x9gknd 3171 5 LVL LVL NNP cord-010119-t1x9gknd 3171 6 performed perform VBD cord-010119-t1x9gknd 3171 7 in in IN cord-010119-t1x9gknd 3171 8 46 46 CD cord-010119-t1x9gknd 3171 9 adult adult NN cord-010119-t1x9gknd 3171 10 patients patient NNS cord-010119-t1x9gknd 3171 11 , , , cord-010119-t1x9gknd 3171 12 and and CC cord-010119-t1x9gknd 3171 13 14 14 CD cord-010119-t1x9gknd 3171 14 LVL LVL NNP cord-010119-t1x9gknd 3171 15 in in IN cord-010119-t1x9gknd 3171 16 11 11 CD cord-010119-t1x9gknd 3171 17 pediatric pediatric JJ cord-010119-t1x9gknd 3171 18 patients patient NNS cord-010119-t1x9gknd 3171 19 treated treat VBN cord-010119-t1x9gknd 3171 20 in in IN cord-010119-t1x9gknd 3171 21 UHC UHC NNP cord-010119-t1x9gknd 3171 22 Zagreb Zagreb NNP cord-010119-t1x9gknd 3171 23 from from IN cord-010119-t1x9gknd 3171 24 March March NNP cord-010119-t1x9gknd 3171 25 2016 2016 CD cord-010119-t1x9gknd 3171 26 till till IN cord-010119-t1x9gknd 3171 27 September September NNP cord-010119-t1x9gknd 3171 28 2016 2016 CD cord-010119-t1x9gknd 3171 29 . . . cord-010119-t1x9gknd 3172 1 Mobilization mobilization NN cord-010119-t1x9gknd 3172 2 regimen regimen NN cord-010119-t1x9gknd 3172 3 combined combine VBN cord-010119-t1x9gknd 3172 4 chemotherapy chemotherapy NN cord-010119-t1x9gknd 3172 5 and and CC cord-010119-t1x9gknd 3172 6 filgrastim filgrastim NN cord-010119-t1x9gknd 3172 7 ; ; : cord-010119-t1x9gknd 3172 8 2 2 CD cord-010119-t1x9gknd 3172 9 poor poor JJ cord-010119-t1x9gknd 3172 10 mobilizes mobilize NNS cord-010119-t1x9gknd 3172 11 received receive VBN cord-010119-t1x9gknd 3172 12 plerixafor plerixafor NN cord-010119-t1x9gknd 3172 13 additionally additionally RB cord-010119-t1x9gknd 3172 14 . . . cord-010119-t1x9gknd 3173 1 A a DT cord-010119-t1x9gknd 3173 2 combination combination NN cord-010119-t1x9gknd 3173 3 of of IN cord-010119-t1x9gknd 3173 4 ACD ACD NNP cord-010119-t1x9gknd 3173 5 - - HYPH cord-010119-t1x9gknd 3173 6 A A NNP cord-010119-t1x9gknd 3173 7 and and CC cord-010119-t1x9gknd 3173 8 heparin heparin NN cord-010119-t1x9gknd 3173 9 was be VBD cord-010119-t1x9gknd 3173 10 used use VBN cord-010119-t1x9gknd 3173 11 as as IN cord-010119-t1x9gknd 3173 12 anticoagulant anticoagulant NN cord-010119-t1x9gknd 3174 1 ( ( -LRB- cord-010119-t1x9gknd 3174 2 ACD ACD NNP cord-010119-t1x9gknd 3174 3 - - HYPH cord-010119-t1x9gknd 3174 4 A a NN cord-010119-t1x9gknd 3174 5 : : : cord-010119-t1x9gknd 3174 6 whole whole JJ cord-010119-t1x9gknd 3174 7 blood blood NN cord-010119-t1x9gknd 3174 8 ratio ratio NN cord-010119-t1x9gknd 3174 9 1:24 1:24 CD cord-010119-t1x9gknd 3174 10 ) ) -RRB- cord-010119-t1x9gknd 3174 11 . . . cord-010119-t1x9gknd 3175 1 In in IN cord-010119-t1x9gknd 3175 2 patients patient NNS cord-010119-t1x9gknd 3175 3 weighting weight VBG cord-010119-t1x9gknd 3175 4 25 25 CD cord-010119-t1x9gknd 3175 5 kg kg NNS cord-010119-t1x9gknd 3175 6 ( ( -LRB- cord-010119-t1x9gknd 3175 7 n59 n59 NN cord-010119-t1x9gknd 3175 8 ) ) -RRB- cord-010119-t1x9gknd 3175 9 , , , cord-010119-t1x9gknd 3175 10 a a DT cord-010119-t1x9gknd 3175 11 RBC RBC NNP cord-010119-t1x9gknd 3175 12 prime prime NN cord-010119-t1x9gknd 3175 13 was be VBD cord-010119-t1x9gknd 3175 14 performed perform VBN cord-010119-t1x9gknd 3175 15 . . . cord-010119-t1x9gknd 3176 1 CD34 CD34 NNP cord-010119-t1x9gknd 3176 2 , , , cord-010119-t1x9gknd 3176 3 lymphocyte(Ly lymphocyte(ly ADD cord-010119-t1x9gknd 3176 4 ) ) -RRB- cord-010119-t1x9gknd 3176 5 and and CC cord-010119-t1x9gknd 3176 6 monocyte(Mo monocyte(mo LS cord-010119-t1x9gknd 3176 7 ) ) -RRB- cord-010119-t1x9gknd 3177 1 collection collection NN cord-010119-t1x9gknd 3177 2 efficiencies efficiency NNS cord-010119-t1x9gknd 3177 3 ( ( -LRB- cord-010119-t1x9gknd 3177 4 CEs CEs NNP cord-010119-t1x9gknd 3177 5 ) ) -RRB- cord-010119-t1x9gknd 3177 6 were be VBD cord-010119-t1x9gknd 3177 7 calculated calculate VBN cord-010119-t1x9gknd 3177 8 . . . cord-010119-t1x9gknd 3178 1 A a DT cord-010119-t1x9gknd 3178 2 customized customized JJ cord-010119-t1x9gknd 3178 3 prediction prediction NN cord-010119-t1x9gknd 3178 4 algorithm algorithm NN cord-010119-t1x9gknd 3178 5 was be VBD cord-010119-t1x9gknd 3178 6 determined determine VBN cord-010119-t1x9gknd 3178 7 on on IN cord-010119-t1x9gknd 3178 8 linear linear JJ cord-010119-t1x9gknd 3178 9 regression regression NN cord-010119-t1x9gknd 3178 10 between between IN cord-010119-t1x9gknd 3178 11 pre pre JJ cord-010119-t1x9gknd 3178 12 - - JJ cord-010119-t1x9gknd 3178 13 CD341cell cd341cell JJ cord-010119-t1x9gknd 3178 14 count count NN cord-010119-t1x9gknd 3178 15 and and CC cord-010119-t1x9gknd 3178 16 CD341cells CD341cells NNP cord-010119-t1x9gknd 3179 1 collected collect VBN cord-010119-t1x9gknd 3179 2 / / SYM cord-010119-t1x9gknd 3179 3 blood blood NN cord-010119-t1x9gknd 3179 4 volume volume NN cord-010119-t1x9gknd 3179 5 processed process VBN cord-010119-t1x9gknd 3179 6 . . . cord-010119-t1x9gknd 3180 1 Prediction prediction NN cord-010119-t1x9gknd 3180 2 accuracy accuracy NN cord-010119-t1x9gknd 3180 3 was be VBD cord-010119-t1x9gknd 3180 4 evaluated evaluate VBN cord-010119-t1x9gknd 3180 5 by by IN cord-010119-t1x9gknd 3180 6 comparing compare VBG cord-010119-t1x9gknd 3180 7 predicted predict VBN cord-010119-t1x9gknd 3180 8 CD34 CD34 NNP cord-010119-t1x9gknd 3180 9 values value NNS cord-010119-t1x9gknd 3180 10 to to IN cord-010119-t1x9gknd 3180 11 real real JJ cord-010119-t1x9gknd 3180 12 CD34 CD34 NNP cord-010119-t1x9gknd 3180 13 yield yield NN cord-010119-t1x9gknd 3180 14 . . . cord-010119-t1x9gknd 3181 1 Results result NNS cord-010119-t1x9gknd 3181 2 are be VBP cord-010119-t1x9gknd 3181 3 presented present VBN cord-010119-t1x9gknd 3181 4 as as IN cord-010119-t1x9gknd 3181 5 median median NN cord-010119-t1x9gknd 3181 6 ( ( -LRB- cord-010119-t1x9gknd 3181 7 IQR IQR NNP cord-010119-t1x9gknd 3181 8 ) ) -RRB- cord-010119-t1x9gknd 3181 9 . . . cord-010119-t1x9gknd 3182 1 Results/ Results/ . cord-010119-t1x9gknd 3183 1 Finding finding NN cord-010119-t1x9gknd 3183 2 : : : cord-010119-t1x9gknd 3184 1 In in IN cord-010119-t1x9gknd 3184 2 both both DT cord-010119-t1x9gknd 3184 3 groups group NNS cord-010119-t1x9gknd 3184 4 , , , cord-010119-t1x9gknd 3184 5 CD34 CD34 NNP cord-010119-t1x9gknd 3184 6 , , , cord-010119-t1x9gknd 3184 7 Ly Ly NNP cord-010119-t1x9gknd 3184 8 and and CC cord-010119-t1x9gknd 3184 9 Mo Mo NNP cord-010119-t1x9gknd 3184 10 CEs CEs NNP cord-010119-t1x9gknd 3184 11 were be VBD cord-010119-t1x9gknd 3184 12 high high JJ cord-010119-t1x9gknd 3184 13 . . . cord-010119-t1x9gknd 3185 1 Target target VB cord-010119-t1x9gknd 3185 2 CD34 CD34 NNP cord-010119-t1x9gknd 3185 3 dose dose NN cord-010119-t1x9gknd 3185 4 was be VBD cord-010119-t1x9gknd 3185 5 successfully successfully RB cord-010119-t1x9gknd 3185 6 reached reach VBN cord-010119-t1x9gknd 3185 7 in in IN cord-010119-t1x9gknd 3185 8 1 1 CD cord-010119-t1x9gknd 3185 9 procedure procedure NN cord-010119-t1x9gknd 3185 10 in in IN cord-010119-t1x9gknd 3185 11 30 30 CD cord-010119-t1x9gknd 3185 12 ( ( -LRB- cord-010119-t1x9gknd 3185 13 65,2%)adults 65,2%)adults CD cord-010119-t1x9gknd 3185 14 and and CC cord-010119-t1x9gknd 3185 15 in in IN cord-010119-t1x9gknd 3185 16 9 9 CD cord-010119-t1x9gknd 3185 17 ( ( -LRB- cord-010119-t1x9gknd 3185 18 81.8 81.8 CD cord-010119-t1x9gknd 3185 19 % % NN cord-010119-t1x9gknd 3185 20 ) ) -RRB- cord-010119-t1x9gknd 3185 21 children child NNS cord-010119-t1x9gknd 3185 22 . . . cord-010119-t1x9gknd 3186 1 All all DT cord-010119-t1x9gknd 3186 2 procedures procedure NNS cord-010119-t1x9gknd 3186 3 were be VBD cord-010119-t1x9gknd 3186 4 well well RB cord-010119-t1x9gknd 3186 5 tolerated tolerate VBN cord-010119-t1x9gknd 3186 6 : : : cord-010119-t1x9gknd 3186 7 adverse adverse JJ cord-010119-t1x9gknd 3186 8 reactions reaction NNS cord-010119-t1x9gknd 3186 9 were be VBD cord-010119-t1x9gknd 3186 10 restricted restrict VBN cord-010119-t1x9gknd 3186 11 to to IN cord-010119-t1x9gknd 3186 12 mild mild JJ cord-010119-t1x9gknd 3186 13 citrate citrate NN cord-010119-t1x9gknd 3186 14 toxicity toxicity NN cord-010119-t1x9gknd 3186 15 symptoms symptom NNS cord-010119-t1x9gknd 3186 16 in in IN cord-010119-t1x9gknd 3186 17 5 5 CD cord-010119-t1x9gknd 3186 18 ( ( -LRB- cord-010119-t1x9gknd 3186 19 7.5 7.5 CD cord-010119-t1x9gknd 3186 20 % % NN cord-010119-t1x9gknd 3186 21 ) ) -RRB- cord-010119-t1x9gknd 3186 22 adults adult NNS cord-010119-t1x9gknd 3186 23 , , , cord-010119-t1x9gknd 3186 24 while while IN cord-010119-t1x9gknd 3186 25 all all DT cord-010119-t1x9gknd 3186 26 pediatric pediatric JJ cord-010119-t1x9gknd 3186 27 apheresis apheresis NN cord-010119-t1x9gknd 3186 28 went go VBD cord-010119-t1x9gknd 3186 29 uneventful uneventful JJ cord-010119-t1x9gknd 3186 30 . . . cord-010119-t1x9gknd 3187 1 No no DT cord-010119-t1x9gknd 3187 2 bleeding bleeding JJ cord-010119-t1x9gknd 3187 3 episodes episode NNS cord-010119-t1x9gknd 3187 4 occurred occur VBD cord-010119-t1x9gknd 3187 5 , , , cord-010119-t1x9gknd 3187 6 and and CC cord-010119-t1x9gknd 3187 7 no no DT cord-010119-t1x9gknd 3187 8 transfusion transfusion NN cord-010119-t1x9gknd 3187 9 was be VBD cord-010119-t1x9gknd 3187 10 needed need VBN cord-010119-t1x9gknd 3187 11 . . . cord-010119-t1x9gknd 3188 1 Product product NN cord-010119-t1x9gknd 3188 2 and and CC cord-010119-t1x9gknd 3188 3 procedure procedure NN cord-010119-t1x9gknd 3188 4 characteristics characteristic NNS cord-010119-t1x9gknd 3188 5 * * NFP cord-010119-t1x9gknd 3189 1 A a DT cord-010119-t1x9gknd 3189 2 high high JJ cord-010119-t1x9gknd 3189 3 correlation correlation NN cord-010119-t1x9gknd 3189 4 between between IN cord-010119-t1x9gknd 3189 5 preCD341cells preCD341cells NNP cord-010119-t1x9gknd 3189 6 and and CC cord-010119-t1x9gknd 3189 7 CD341cells cd341cell NNS cord-010119-t1x9gknd 3189 8 collected/ collected/ POS cord-010119-t1x9gknd 3189 9 blood blood NN cord-010119-t1x9gknd 3189 10 volume volume NN cord-010119-t1x9gknd 3189 11 was be VBD cord-010119-t1x9gknd 3189 12 observed observe VBN cord-010119-t1x9gknd 3189 13 in in IN cord-010119-t1x9gknd 3189 14 both both DT cord-010119-t1x9gknd 3189 15 groups group NNS cord-010119-t1x9gknd 3189 16 ( ( -LRB- cord-010119-t1x9gknd 3189 17 r r NNP cord-010119-t1x9gknd 3189 18 2 2 CD cord-010119-t1x9gknd 3189 19 50.97 50.97 CD cord-010119-t1x9gknd 3189 20 and and CC cord-010119-t1x9gknd 3189 21 0.83 0.83 CD cord-010119-t1x9gknd 3189 22 in in IN cord-010119-t1x9gknd 3189 23 adults adult NNS cord-010119-t1x9gknd 3189 24 and and CC cord-010119-t1x9gknd 3189 25 children child NNS cord-010119-t1x9gknd 3189 26 respectively respectively RB cord-010119-t1x9gknd 3189 27 , , , cord-010119-t1x9gknd 3189 28 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 3189 29 ) ) -RRB- cord-010119-t1x9gknd 3189 30 suggesting suggest VBG cord-010119-t1x9gknd 3189 31 CD34 CD34 NNP cord-010119-t1x9gknd 3189 32 yield yield NN cord-010119-t1x9gknd 3189 33 could could MD cord-010119-t1x9gknd 3189 34 be be VB cord-010119-t1x9gknd 3189 35 predicted predict VBN cord-010119-t1x9gknd 3189 36 based base VBN cord-010119-t1x9gknd 3189 37 on on IN cord-010119-t1x9gknd 3189 38 preCD341cells precd341cell NNS cord-010119-t1x9gknd 3189 39 and and CC cord-010119-t1x9gknd 3189 40 blood blood NN cord-010119-t1x9gknd 3189 41 volume volume NN cord-010119-t1x9gknd 3189 42 to to IN cord-010119-t1x9gknd 3189 43 process process NN cord-010119-t1x9gknd 3189 44 . . . cord-010119-t1x9gknd 3190 1 Linear linear JJ cord-010119-t1x9gknd 3190 2 regression regression NN cord-010119-t1x9gknd 3190 3 equations equation NNS cord-010119-t1x9gknd 3190 4 served serve VBD cord-010119-t1x9gknd 3190 5 as as IN cord-010119-t1x9gknd 3190 6 prediction prediction NN cord-010119-t1x9gknd 3190 7 algorithm algorithm NN cord-010119-t1x9gknd 3190 8 . . . cord-010119-t1x9gknd 3191 1 The the DT cord-010119-t1x9gknd 3191 2 high high JJ cord-010119-t1x9gknd 3191 3 correlation correlation NN cord-010119-t1x9gknd 3191 4 between between IN cord-010119-t1x9gknd 3191 5 predicted predict VBN cord-010119-t1x9gknd 3191 6 CD34 CD34 NNP cord-010119-t1x9gknd 3191 7 yield yield NN cord-010119-t1x9gknd 3191 8 and and CC cord-010119-t1x9gknd 3191 9 observed observe VBD cord-010119-t1x9gknd 3191 10 CD34 CD34 NNP cord-010119-t1x9gknd 3191 11 yield yield NN cord-010119-t1x9gknd 3191 12 ( ( -LRB- cord-010119-t1x9gknd 3191 13 r r NN cord-010119-t1x9gknd 3191 14 2 2 CD cord-010119-t1x9gknd 3191 15 50.95 50.95 CD cord-010119-t1x9gknd 3191 16 and and CC cord-010119-t1x9gknd 3191 17 0.82 0.82 CD cord-010119-t1x9gknd 3191 18 in in IN cord-010119-t1x9gknd 3191 19 adults adult NNS cord-010119-t1x9gknd 3191 20 and and CC cord-010119-t1x9gknd 3191 21 children child NNS cord-010119-t1x9gknd 3191 22 respectively respectively RB cord-010119-t1x9gknd 3191 23 , , , cord-010119-t1x9gknd 3191 24 p<0.001 p<0.001 CD cord-010119-t1x9gknd 3191 25 ) ) -RRB- cord-010119-t1x9gknd 3191 26 showed show VBD cord-010119-t1x9gknd 3191 27 accuracy accuracy NN cord-010119-t1x9gknd 3191 28 of of IN cord-010119-t1x9gknd 3191 29 the the DT cord-010119-t1x9gknd 3191 30 algorithm algorithm NN cord-010119-t1x9gknd 3191 31 . . . cord-010119-t1x9gknd 3192 1 Implementation implementation NN cord-010119-t1x9gknd 3192 2 of of IN cord-010119-t1x9gknd 3192 3 the the DT cord-010119-t1x9gknd 3192 4 algorithm algorithm NN cord-010119-t1x9gknd 3192 5 could could MD cord-010119-t1x9gknd 3192 6 have have VB cord-010119-t1x9gknd 3192 7 allowed allow VBN cord-010119-t1x9gknd 3192 8 sparing spare VBG cord-010119-t1x9gknd 3192 9 a a DT cord-010119-t1x9gknd 3192 10 median median NN cord-010119-t1x9gknd 3192 11 of of IN cord-010119-t1x9gknd 3192 12 10.1(8.9 10.1(8.9 CD cord-010119-t1x9gknd 3192 13 - - SYM cord-010119-t1x9gknd 3192 14 12.9)L 12.9)l CD cord-010119-t1x9gknd 3192 15 of of IN cord-010119-t1x9gknd 3192 16 blood blood NN cord-010119-t1x9gknd 3192 17 in in IN cord-010119-t1x9gknd 3192 18 20 20 CD cord-010119-t1x9gknd 3192 19 adult adult NN cord-010119-t1x9gknd 3192 20 procedures procedure NNS cord-010119-t1x9gknd 3192 21 , , , cord-010119-t1x9gknd 3192 22 and and CC cord-010119-t1x9gknd 3192 23 5.9(3.5 5.9(3.5 CD cord-010119-t1x9gknd 3192 24 - - HYPH cord-010119-t1x9gknd 3192 25 7.8)L 7.8)l CD cord-010119-t1x9gknd 3192 26 in in IN cord-010119-t1x9gknd 3192 27 7 7 CD cord-010119-t1x9gknd 3192 28 pediatric pediatric JJ cord-010119-t1x9gknd 3192 29 procedures procedure NNS cord-010119-t1x9gknd 3192 30 . . . cord-010119-t1x9gknd 3193 1 Conclusion conclusion NN cord-010119-t1x9gknd 3193 2 : : : cord-010119-t1x9gknd 3193 3 LVL LVL NNP cord-010119-t1x9gknd 3193 4 performed perform VBD cord-010119-t1x9gknd 3193 5 using use VBG cord-010119-t1x9gknd 3193 6 Spectra Spectra NNP cord-010119-t1x9gknd 3193 7 Optia Optia NNP cord-010119-t1x9gknd 3193 8 CMNC CMNC NNP cord-010119-t1x9gknd 3193 9 protocol protocol NN cord-010119-t1x9gknd 3193 10 is be VBZ cord-010119-t1x9gknd 3193 11 safe safe JJ cord-010119-t1x9gknd 3193 12 and and CC cord-010119-t1x9gknd 3193 13 efficient efficient JJ cord-010119-t1x9gknd 3193 14 in in IN cord-010119-t1x9gknd 3193 15 adults adult NNS cord-010119-t1x9gknd 3193 16 and and CC cord-010119-t1x9gknd 3193 17 in in IN cord-010119-t1x9gknd 3193 18 low low JJ cord-010119-t1x9gknd 3193 19 body body NN cord-010119-t1x9gknd 3193 20 weight weight NN cord-010119-t1x9gknd 3193 21 children child NNS cord-010119-t1x9gknd 3193 22 . . . cord-010119-t1x9gknd 3194 1 High high JJ cord-010119-t1x9gknd 3194 2 CD34 CD34 NNP cord-010119-t1x9gknd 3194 3 , , , cord-010119-t1x9gknd 3194 4 Ly Ly NNP cord-010119-t1x9gknd 3194 5 and and CC cord-010119-t1x9gknd 3194 6 Mo Mo NNP cord-010119-t1x9gknd 3194 7 CE1 CE1 VBD cord-010119-t1x9gknd 3194 8 were be VBD cord-010119-t1x9gknd 3194 9 observed observe VBN cord-010119-t1x9gknd 3194 10 in in IN cord-010119-t1x9gknd 3194 11 both both DT cord-010119-t1x9gknd 3194 12 groups group NNS cord-010119-t1x9gknd 3194 13 . . . cord-010119-t1x9gknd 3195 1 Implementation implementation NN cord-010119-t1x9gknd 3195 2 of of IN cord-010119-t1x9gknd 3195 3 a a DT cord-010119-t1x9gknd 3195 4 predictive predictive JJ cord-010119-t1x9gknd 3195 5 algorithm algorithm NN cord-010119-t1x9gknd 3195 6 can can MD cord-010119-t1x9gknd 3195 7 reliably reliably RB cord-010119-t1x9gknd 3195 8 minimize minimize VB cord-010119-t1x9gknd 3195 9 blood blood NN cord-010119-t1x9gknd 3195 10 volume volume NN cord-010119-t1x9gknd 3195 11 processed process VBN cord-010119-t1x9gknd 3195 12 , , , cord-010119-t1x9gknd 3195 13 shorten shorten VB cord-010119-t1x9gknd 3195 14 procedure procedure NN cord-010119-t1x9gknd 3195 15 duration duration NN cord-010119-t1x9gknd 3195 16 , , , cord-010119-t1x9gknd 3195 17 reduce reduce VB cord-010119-t1x9gknd 3195 18 anticoagulant anticoagulant JJ cord-010119-t1x9gknd 3195 19 volumes volume NNS cord-010119-t1x9gknd 3195 20 infused infuse VBN cord-010119-t1x9gknd 3195 21 , , , cord-010119-t1x9gknd 3195 22 and and CC cord-010119-t1x9gknd 3195 23 improve improve VB cord-010119-t1x9gknd 3195 24 patient patient JJ cord-010119-t1x9gknd 3195 25 comfort comfort NN cord-010119-t1x9gknd 3195 26 . . . cord-010119-t1x9gknd 3196 1 Mesenchymal Mesenchymal NNP cord-010119-t1x9gknd 3196 2 Stem Stem NNP cord-010119-t1x9gknd 3196 3 Cell cell NN cord-010119-t1x9gknd 3196 4 Therapy therapy NN cord-010119-t1x9gknd 3196 5 in in IN cord-010119-t1x9gknd 3196 6 Steroid Steroid NNP cord-010119-t1x9gknd 3196 7 Refractory Refractory NNP cord-010119-t1x9gknd 3196 8 Graft Graft NNP cord-010119-t1x9gknd 3196 9 - - HYPH cord-010119-t1x9gknd 3196 10 Versus Versus NNP cord-010119-t1x9gknd 3196 11 - - HYPH cord-010119-t1x9gknd 3196 12 Host Host NNP cord-010119-t1x9gknd 3196 13 Disease Disease NNP cord-010119-t1x9gknd 3196 14 ( ( -LRB- cord-010119-t1x9gknd 3196 15 GVHD GVHD NNP cord-010119-t1x9gknd 3196 16 ) ) -RRB- cord-010119-t1x9gknd 3197 1 Emese Emese NNP cord-010119-t1x9gknd 3197 2 Molnar Molnar NNP cord-010119-t1x9gknd 3197 3 * * NFP cord-010119-t1x9gknd 3197 4 1 1 CD cord-010119-t1x9gknd 3197 5 , , , cord-010119-t1x9gknd 3197 6 Aniko Aniko NNP cord-010119-t1x9gknd 3197 7 Barta Barta NNP cord-010119-t1x9gknd 3197 8 2 2 CD cord-010119-t1x9gknd 3197 9 , , , cord-010119-t1x9gknd 3197 10 Arpad Arpad NNP cord-010119-t1x9gknd 3197 11 Batai Batai NNP cord-010119-t1x9gknd 3197 12 2 2 CD cord-010119-t1x9gknd 3197 13 , , , cord-010119-t1x9gknd 3197 14 Zoltan Zoltan NNP cord-010119-t1x9gknd 3197 15 Csukly Csukly NNP cord-010119-t1x9gknd 3197 16 2 2 CD cord-010119-t1x9gknd 3197 17 , , , cord-010119-t1x9gknd 3197 18 Zita Zita NNP cord-010119-t1x9gknd 3197 19 Farkas Farkas NNP cord-010119-t1x9gknd 3197 20 2 2 CD cord-010119-t1x9gknd 3197 21 , , , cord-010119-t1x9gknd 3197 22 Laszlo Laszlo NNP cord-010119-t1x9gknd 3197 23 Gopcsa Gopcsa NNP cord-010119-t1x9gknd 3197 24 2 2 CD cord-010119-t1x9gknd 3198 1 , , , cord-010119-t1x9gknd 3198 2 Gabor Gabor NNP cord-010119-t1x9gknd 3198 3 Tatai Tatai NNP cord-010119-t1x9gknd 3198 4 Background Background NNP cord-010119-t1x9gknd 3198 5 / / SYM cord-010119-t1x9gknd 3198 6 Case Case NNP cord-010119-t1x9gknd 3198 7 Studies Studies NNPS cord-010119-t1x9gknd 3198 8 : : : cord-010119-t1x9gknd 3198 9 Steroid steroid JJ cord-010119-t1x9gknd 3198 10 refractory refractory JJ cord-010119-t1x9gknd 3198 11 acute acute JJ cord-010119-t1x9gknd 3198 12 graft graft NN cord-010119-t1x9gknd 3198 13 - - HYPH cord-010119-t1x9gknd 3198 14 versus versus IN cord-010119-t1x9gknd 3198 15 - - HYPH cord-010119-t1x9gknd 3198 16 host host NN cord-010119-t1x9gknd 3198 17 disease disease NN cord-010119-t1x9gknd 3198 18 ( ( -LRB- cord-010119-t1x9gknd 3198 19 GvHD GvHD NNP cord-010119-t1x9gknd 3198 20 ) ) -RRB- cord-010119-t1x9gknd 3198 21 is be VBZ cord-010119-t1x9gknd 3198 22 a a DT cord-010119-t1x9gknd 3198 23 serious serious JJ cord-010119-t1x9gknd 3198 24 complication complication NN cord-010119-t1x9gknd 3198 25 of of IN cord-010119-t1x9gknd 3198 26 allogeneic allogeneic NN cord-010119-t1x9gknd 3198 27 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 3198 28 stem stem NN cord-010119-t1x9gknd 3198 29 cell cell NN cord-010119-t1x9gknd 3198 30 transplantation transplantation NN cord-010119-t1x9gknd 3198 31 ( ( -LRB- cord-010119-t1x9gknd 3198 32 HSCT HSCT NNP cord-010119-t1x9gknd 3198 33 ) ) -RRB- cord-010119-t1x9gknd 3198 34 . . . cord-010119-t1x9gknd 3199 1 More More JJR cord-010119-t1x9gknd 3199 2 experience experience NN cord-010119-t1x9gknd 3199 3 accumulates accumulate VBZ cord-010119-t1x9gknd 3199 4 in in IN cord-010119-t1x9gknd 3199 5 the the DT cord-010119-t1x9gknd 3199 6 immunomodulatory immunomodulatory JJ cord-010119-t1x9gknd 3199 7 effect effect NN cord-010119-t1x9gknd 3199 8 of of IN cord-010119-t1x9gknd 3199 9 mesenchymal mesenchymal JJ cord-010119-t1x9gknd 3199 10 stem stem NN cord-010119-t1x9gknd 3199 11 cell cell NN cord-010119-t1x9gknd 3199 12 ( ( -LRB- cord-010119-t1x9gknd 3199 13 MSC MSC NNP cord-010119-t1x9gknd 3199 14 ) ) -RRB- cord-010119-t1x9gknd 3199 15 infusion infusion NN cord-010119-t1x9gknd 3199 16 in in IN cord-010119-t1x9gknd 3199 17 numerous numerous JJ cord-010119-t1x9gknd 3199 18 immunopathological immunopathological JJ cord-010119-t1x9gknd 3199 19 disorders disorder NNS cord-010119-t1x9gknd 3199 20 -such -such : cord-010119-t1x9gknd 3199 21 as as IN cord-010119-t1x9gknd 3199 22 GvHD GvHD NNP cord-010119-t1x9gknd 3199 23 -and -and CC cord-010119-t1x9gknd 3199 24 signals signal NNS cord-010119-t1x9gknd 3199 25 . . . cord-010119-t1x9gknd 3200 1 MSCs msc NNS cord-010119-t1x9gknd 3200 2 have have VBP cord-010119-t1x9gknd 3200 3 a a DT cord-010119-t1x9gknd 3200 4 HLArestrictive hlarestrictive JJ cord-010119-t1x9gknd 3200 5 and and CC cord-010119-t1x9gknd 3200 6 non non JJ cord-010119-t1x9gknd 3200 7 - - JJ cord-010119-t1x9gknd 3200 8 immunogenic immunogenic JJ cord-010119-t1x9gknd 3200 9 nature nature NN cord-010119-t1x9gknd 3200 10 . . . cord-010119-t1x9gknd 3201 1 Study Study NNP cord-010119-t1x9gknd 3201 2 Design Design NNP cord-010119-t1x9gknd 3201 3 / / SYM cord-010119-t1x9gknd 3201 4 Method method NN cord-010119-t1x9gknd 3201 5 : : : cord-010119-t1x9gknd 3201 6 We -PRON- PRP cord-010119-t1x9gknd 3201 7 have have VBP cord-010119-t1x9gknd 3201 8 evaluated evaluate VBN cord-010119-t1x9gknd 3201 9 the the DT cord-010119-t1x9gknd 3201 10 efficacy efficacy NN cord-010119-t1x9gknd 3201 11 of of IN cord-010119-t1x9gknd 3201 12 MSC MSC NNP cord-010119-t1x9gknd 3201 13 transfusions transfusion NNS cord-010119-t1x9gknd 3201 14 in in IN cord-010119-t1x9gknd 3201 15 cases case NNS cord-010119-t1x9gknd 3201 16 of of IN cord-010119-t1x9gknd 3201 17 acute acute JJ cord-010119-t1x9gknd 3201 18 GvHD gvhd NN cord-010119-t1x9gknd 3201 19 refractory refractory JJ cord-010119-t1x9gknd 3201 20 to to IN cord-010119-t1x9gknd 3201 21 conventional conventional JJ cord-010119-t1x9gknd 3201 22 immunosuppressive immunosuppressive JJ cord-010119-t1x9gknd 3201 23 treatment treatment NN cord-010119-t1x9gknd 3201 24 . . . cord-010119-t1x9gknd 3202 1 The the DT cord-010119-t1x9gknd 3202 2 patients patient NNS cord-010119-t1x9gknd 3202 3 with with IN cord-010119-t1x9gknd 3202 4 steroid steroid JJ cord-010119-t1x9gknd 3202 5 - - HYPH cord-010119-t1x9gknd 3202 6 resistant resistant JJ cord-010119-t1x9gknd 3202 7 GvHD GvHD NNP cord-010119-t1x9gknd 3202 8 had have VBD cord-010119-t1x9gknd 3202 9 received receive VBN cord-010119-t1x9gknd 3202 10 third third JJ cord-010119-t1x9gknd 3202 11 - - HYPH cord-010119-t1x9gknd 3202 12 party party NN cord-010119-t1x9gknd 3202 13 MSCs msc NNS cord-010119-t1x9gknd 3202 14 ( ( -LRB- cord-010119-t1x9gknd 3202 15 derived derive VBN cord-010119-t1x9gknd 3202 16 from from IN cord-010119-t1x9gknd 3202 17 Wharton Wharton NNP cord-010119-t1x9gknd 3202 18 's 's POS cord-010119-t1x9gknd 3202 19 jelly jelly NN cord-010119-t1x9gknd 3202 20 and and CC cord-010119-t1x9gknd 3202 21 bone bone NN cord-010119-t1x9gknd 3202 22 marrow marrow NN cord-010119-t1x9gknd 3202 23 ) ) -RRB- cord-010119-t1x9gknd 3202 24 4 4 CD cord-010119-t1x9gknd 3202 25 times time NNS cord-010119-t1x9gknd 3202 26 per per IN cord-010119-t1x9gknd 3202 27 case case NN cord-010119-t1x9gknd 3202 28 weekly weekly RB cord-010119-t1x9gknd 3202 29 at at IN cord-010119-t1x9gknd 3202 30 a a DT cord-010119-t1x9gknd 3202 31 dose dose NN cord-010119-t1x9gknd 3202 32 of of IN cord-010119-t1x9gknd 3202 33 1 1 CD cord-010119-t1x9gknd 3202 34 million million CD cord-010119-t1x9gknd 3202 35 cells cell NNS cord-010119-t1x9gknd 3202 36 / / SYM cord-010119-t1x9gknd 3202 37 kg kg NNS cord-010119-t1x9gknd 3202 38 . . . cord-010119-t1x9gknd 3203 1 Clinical clinical JJ cord-010119-t1x9gknd 3203 2 response response NN cord-010119-t1x9gknd 3203 3 was be VBD cord-010119-t1x9gknd 3203 4 assessed assess VBN cord-010119-t1x9gknd 3203 5 28 28 CD cord-010119-t1x9gknd 3203 6 days day NNS cord-010119-t1x9gknd 3203 7 after after IN cord-010119-t1x9gknd 3203 8 administering administer VBG cord-010119-t1x9gknd 3203 9 the the DT cord-010119-t1x9gknd 3203 10 first first JJ cord-010119-t1x9gknd 3203 11 dose dose NN cord-010119-t1x9gknd 3203 12 . . . cord-010119-t1x9gknd 3204 1 Complete complete JJ cord-010119-t1x9gknd 3204 2 remission remission NN cord-010119-t1x9gknd 3204 3 was be VBD cord-010119-t1x9gknd 3204 4 defined define VBN cord-010119-t1x9gknd 3204 5 as as IN cord-010119-t1x9gknd 3204 6 the the DT cord-010119-t1x9gknd 3204 7 complete complete JJ cord-010119-t1x9gknd 3204 8 disappearance disappearance NN cord-010119-t1x9gknd 3204 9 of of IN cord-010119-t1x9gknd 3204 10 symptoms symptom NNS cord-010119-t1x9gknd 3204 11 . . . cord-010119-t1x9gknd 3205 1 Partial partial JJ cord-010119-t1x9gknd 3205 2 remission remission NN cord-010119-t1x9gknd 3205 3 was be VBD cord-010119-t1x9gknd 3205 4 assessed assess VBN cord-010119-t1x9gknd 3205 5 by by IN cord-010119-t1x9gknd 3205 6 the the DT cord-010119-t1x9gknd 3205 7 significant significant JJ cord-010119-t1x9gknd 3205 8 relief relief NN cord-010119-t1x9gknd 3205 9 of of IN cord-010119-t1x9gknd 3205 10 symptomsand symptomsand NN cord-010119-t1x9gknd 3205 11 by by IN cord-010119-t1x9gknd 3205 12 the the DT cord-010119-t1x9gknd 3205 13 general general JJ cord-010119-t1x9gknd 3205 14 improvement improvement NN cord-010119-t1x9gknd 3205 15 of of IN cord-010119-t1x9gknd 3205 16 the the DT cord-010119-t1x9gknd 3205 17 patient patient NN cord-010119-t1x9gknd 3205 18 's 's POS cord-010119-t1x9gknd 3205 19 condition condition NN cord-010119-t1x9gknd 3205 20 . . . cord-010119-t1x9gknd 3206 1 Results result NNS cord-010119-t1x9gknd 3206 2 / / SYM cord-010119-t1x9gknd 3206 3 Finding finding NN cord-010119-t1x9gknd 3206 4 : : : cord-010119-t1x9gknd 3206 5 In in IN cord-010119-t1x9gknd 3206 6 all all DT cord-010119-t1x9gknd 3206 7 12 12 CD cord-010119-t1x9gknd 3206 8 patients patient NNS cord-010119-t1x9gknd 3206 9 had have VBD cord-010119-t1x9gknd 3206 10 received receive VBN cord-010119-t1x9gknd 3206 11 13 13 CD cord-010119-t1x9gknd 3206 12 cycles cycle NNS cord-010119-t1x9gknd 3206 13 of of IN cord-010119-t1x9gknd 3206 14 MSCtreatment MSCtreatment NNP cord-010119-t1x9gknd 3206 15 ( ( -LRB- cord-010119-t1x9gknd 3206 16 4 4 CD cord-010119-t1x9gknd 3206 17 dose dose NN cord-010119-t1x9gknd 3206 18 per per IN cord-010119-t1x9gknd 3206 19 cycle cycle NN cord-010119-t1x9gknd 3206 20 ) ) -RRB- cord-010119-t1x9gknd 3206 21 . . . cord-010119-t1x9gknd 3207 1 The the DT cord-010119-t1x9gknd 3207 2 median median JJ cord-010119-t1x9gknd 3207 3 age age NN cord-010119-t1x9gknd 3207 4 was be VBD cord-010119-t1x9gknd 3207 5 47 47 CD cord-010119-t1x9gknd 3207 6 years year NNS cord-010119-t1x9gknd 3207 7 old old JJ cord-010119-t1x9gknd 3207 8 ( ( -LRB- cord-010119-t1x9gknd 3207 9 19 19 CD cord-010119-t1x9gknd 3207 10 - - SYM cord-010119-t1x9gknd 3207 11 56 56 CD cord-010119-t1x9gknd 3207 12 ) ) -RRB- cord-010119-t1x9gknd 3207 13 with with IN cord-010119-t1x9gknd 3207 14 a a DT cord-010119-t1x9gknd 3207 15 male male JJ cord-010119-t1x9gknd 3207 16 / / SYM cord-010119-t1x9gknd 3207 17 female female JJ cord-010119-t1x9gknd 3207 18 ratio ratio NN cord-010119-t1x9gknd 3207 19 of of IN cord-010119-t1x9gknd 3207 20 1:2 1:2 CD cord-010119-t1x9gknd 3207 21 . . . cord-010119-t1x9gknd 3208 1 Distribution distribution NN cord-010119-t1x9gknd 3208 2 of of IN cord-010119-t1x9gknd 3208 3 the the DT cord-010119-t1x9gknd 3208 4 original original JJ cord-010119-t1x9gknd 3208 5 malignancies malignancy NNS cord-010119-t1x9gknd 3208 6 ( ( -LRB- cord-010119-t1x9gknd 3208 7 n n NN cord-010119-t1x9gknd 3208 8 ) ) -RRB- cord-010119-t1x9gknd 3208 9 : : : cord-010119-t1x9gknd 3208 10 acute acute JJ cord-010119-t1x9gknd 3208 11 myeloid myeloid JJ cord-010119-t1x9gknd 3208 12 leukemia leukemia NN cord-010119-t1x9gknd 3208 13 : : : cord-010119-t1x9gknd 3208 14 6 6 CD cord-010119-t1x9gknd 3209 1 ; ; : cord-010119-t1x9gknd 3209 2 acute acute JJ cord-010119-t1x9gknd 3209 3 lymphoblastic lymphoblastic NNP cord-010119-t1x9gknd 3210 1 leukemia leukemia NN cord-010119-t1x9gknd 3210 2 : : : cord-010119-t1x9gknd 3210 3 2 2 LS cord-010119-t1x9gknd 3210 4 ; ; : cord-010119-t1x9gknd 3210 5 myelofibrosis myelofibrosis NNP cord-010119-t1x9gknd 3210 6 : : : cord-010119-t1x9gknd 3210 7 1 1 CD cord-010119-t1x9gknd 3210 8 ; ; : cord-010119-t1x9gknd 3211 1 myelodysplastic myelodysplastic JJ cord-010119-t1x9gknd 3211 2 syndrome syndrome NN cord-010119-t1x9gknd 3211 3 : : : cord-010119-t1x9gknd 3211 4 1 1 CD cord-010119-t1x9gknd 3211 5 ; ; , cord-010119-t1x9gknd 3211 6 multiple multiple JJ cord-010119-t1x9gknd 3211 7 myeloma myeloma NN cord-010119-t1x9gknd 3211 8 : : : cord-010119-t1x9gknd 3211 9 1 1 LS cord-010119-t1x9gknd 3211 10 ; ; : cord-010119-t1x9gknd 3211 11 T t NN cord-010119-t1x9gknd 3211 12 - - HYPH cord-010119-t1x9gknd 3211 13 cell cell NN cord-010119-t1x9gknd 3211 14 lymphoma lymphoma NN cord-010119-t1x9gknd 3211 15 : : : cord-010119-t1x9gknd 3211 16 1 1 CD cord-010119-t1x9gknd 3211 17 . . . cord-010119-t1x9gknd 3212 1 Nine nine CD cord-010119-t1x9gknd 3212 2 patients patient NNS cord-010119-t1x9gknd 3212 3 had have VBD cord-010119-t1x9gknd 3212 4 undergone undergo VBN cord-010119-t1x9gknd 3212 5 allogeneic allogeneic IN cord-010119-t1x9gknd 3212 6 HSCT HSCT NNP cord-010119-t1x9gknd 3212 7 with with IN cord-010119-t1x9gknd 3212 8 matched match VBN cord-010119-t1x9gknd 3212 9 unrelated unrelated JJ cord-010119-t1x9gknd 3212 10 donors donor NNS cord-010119-t1x9gknd 3212 11 , , , cord-010119-t1x9gknd 3212 12 the the DT cord-010119-t1x9gknd 3212 13 other other JJ cord-010119-t1x9gknd 3212 14 three three CD cord-010119-t1x9gknd 3212 15 had have VBD cord-010119-t1x9gknd 3212 16 stem stem NN cord-010119-t1x9gknd 3212 17 cells cell NNS cord-010119-t1x9gknd 3212 18 derived derive VBN cord-010119-t1x9gknd 3212 19 from from IN cord-010119-t1x9gknd 3212 20 HLA HLA NNP cord-010119-t1x9gknd 3212 21 - - HYPH cord-010119-t1x9gknd 3212 22 identic identic JJ cord-010119-t1x9gknd 3212 23 relatives relative NNS cord-010119-t1x9gknd 3212 24 . . . cord-010119-t1x9gknd 3213 1 The the DT cord-010119-t1x9gknd 3213 2 first first JJ cord-010119-t1x9gknd 3213 3 episode episode NN cord-010119-t1x9gknd 3213 4 of of IN cord-010119-t1x9gknd 3213 5 GvHD GvHD NNP cord-010119-t1x9gknd 3213 6 after after IN cord-010119-t1x9gknd 3213 7 HSCT HSCT NNP cord-010119-t1x9gknd 3213 8 was be VBD cord-010119-t1x9gknd 3213 9 started start VBN cord-010119-t1x9gknd 3213 10 on on IN cord-010119-t1x9gknd 3213 11 the the DT cord-010119-t1x9gknd 3213 12 median median JJ cord-010119-t1x9gknd 3213 13 63rd 63rd JJ cord-010119-t1x9gknd 3213 14 day day NN cord-010119-t1x9gknd 3213 15 ( ( -LRB- cord-010119-t1x9gknd 3213 16 7 7 CD cord-010119-t1x9gknd 3213 17 - - SYM cord-010119-t1x9gknd 3213 18 455 455 CD cord-010119-t1x9gknd 3213 19 ) ) -RRB- cord-010119-t1x9gknd 3213 20 . . . cord-010119-t1x9gknd 3214 1 The the DT cord-010119-t1x9gknd 3214 2 involved involved JJ cord-010119-t1x9gknd 3214 3 organs organ NNS cord-010119-t1x9gknd 3214 4 were be VBD cord-010119-t1x9gknd 3214 5 skin skin NN cord-010119-t1x9gknd 3214 6 ( ( -LRB- cord-010119-t1x9gknd 3214 7 2 2 CD cord-010119-t1x9gknd 3214 8 ) ) -RRB- cord-010119-t1x9gknd 3214 9 , , , cord-010119-t1x9gknd 3214 10 gut gut NNP cord-010119-t1x9gknd 3214 11 ( ( -LRB- cord-010119-t1x9gknd 3214 12 4 4 CD cord-010119-t1x9gknd 3214 13 ) ) -RRB- cord-010119-t1x9gknd 3214 14 , , , cord-010119-t1x9gknd 3214 15 skin skin NN cord-010119-t1x9gknd 3214 16 and and CC cord-010119-t1x9gknd 3214 17 gut gut NN cord-010119-t1x9gknd 3214 18 combined combine VBN cord-010119-t1x9gknd 3214 19 ( ( -LRB- cord-010119-t1x9gknd 3214 20 7 7 CD cord-010119-t1x9gknd 3214 21 ) ) -RRB- cord-010119-t1x9gknd 3214 22 and and CC cord-010119-t1x9gknd 3214 23 even even RB cord-010119-t1x9gknd 3214 24 lung lung NN cord-010119-t1x9gknd 3214 25 in in IN cord-010119-t1x9gknd 3214 26 3 3 CD cord-010119-t1x9gknd 3214 27 cases case NNS cord-010119-t1x9gknd 3214 28 . . . cord-010119-t1x9gknd 3215 1 The the DT cord-010119-t1x9gknd 3215 2 median median JJ cord-010119-t1x9gknd 3215 3 time time NN cord-010119-t1x9gknd 3215 4 of of IN cord-010119-t1x9gknd 3215 5 MSC MSC NNP cord-010119-t1x9gknd 3215 6 's 's POS cord-010119-t1x9gknd 3215 7 first first JJ cord-010119-t1x9gknd 3215 8 infusion infusion NN cord-010119-t1x9gknd 3215 9 was be VBD cord-010119-t1x9gknd 3215 10 274 274 CD cord-010119-t1x9gknd 3215 11 days day NNS cord-010119-t1x9gknd 3215 12 after after IN cord-010119-t1x9gknd 3215 13 the the DT cord-010119-t1x9gknd 3215 14 stem stem NN cord-010119-t1x9gknd 3215 15 cell cell NN cord-010119-t1x9gknd 3215 16 transplantation transplantation NN cord-010119-t1x9gknd 3215 17 ( ( -LRB- cord-010119-t1x9gknd 3215 18 HSCT HSCT NNP cord-010119-t1x9gknd 3215 19 ) ) -RRB- cord-010119-t1x9gknd 3215 20 and and CC cord-010119-t1x9gknd 3215 21 165 165 CD cord-010119-t1x9gknd 3215 22 ( ( -LRB- cord-010119-t1x9gknd 3215 23 19 19 CD cord-010119-t1x9gknd 3215 24 - - SYM cord-010119-t1x9gknd 3215 25 1974 1974 CD cord-010119-t1x9gknd 3215 26 ) ) -RRB- cord-010119-t1x9gknd 3215 27 days day NNS cord-010119-t1x9gknd 3215 28 after after IN cord-010119-t1x9gknd 3215 29 the the DT cord-010119-t1x9gknd 3215 30 first first JJ cord-010119-t1x9gknd 3215 31 episode episode NN cord-010119-t1x9gknd 3215 32 of of IN cord-010119-t1x9gknd 3215 33 GvHD GvHD NNP cord-010119-t1x9gknd 3215 34 . . . cord-010119-t1x9gknd 3216 1 4 4 CD cord-010119-t1x9gknd 3216 2 of of IN cord-010119-t1x9gknd 3216 3 the the DT cord-010119-t1x9gknd 3216 4 13 13 CD cord-010119-t1x9gknd 3216 5 cycles cycle NNS cord-010119-t1x9gknd 3216 6 of of IN cord-010119-t1x9gknd 3216 7 MSC MSC NNP cord-010119-t1x9gknd 3216 8 - - HYPH cord-010119-t1x9gknd 3216 9 treatment treatment NN cord-010119-t1x9gknd 3216 10 led lead VBD cord-010119-t1x9gknd 3216 11 to to TO cord-010119-t1x9gknd 3216 12 complete complete VB cord-010119-t1x9gknd 3216 13 remission remission NN cord-010119-t1x9gknd 3216 14 ( ( -LRB- cord-010119-t1x9gknd 3216 15 30.8 30.8 CD cord-010119-t1x9gknd 3216 16 % % NN cord-010119-t1x9gknd 3216 17 ) ) -RRB- cord-010119-t1x9gknd 3216 18 and and CC cord-010119-t1x9gknd 3216 19 7 7 CD cord-010119-t1x9gknd 3216 20 resulted result VBD cord-010119-t1x9gknd 3216 21 inpartial inpartial JJ cord-010119-t1x9gknd 3216 22 remission remission NN cord-010119-t1x9gknd 3216 23 ( ( -LRB- cord-010119-t1x9gknd 3216 24 53.8 53.8 CD cord-010119-t1x9gknd 3216 25 % % NN cord-010119-t1x9gknd 3216 26 ) ) -RRB- cord-010119-t1x9gknd 3216 27 . . . cord-010119-t1x9gknd 3217 1 Conclusion conclusion NN cord-010119-t1x9gknd 3217 2 : : : cord-010119-t1x9gknd 3217 3 We -PRON- PRP cord-010119-t1x9gknd 3217 4 have have VBP cord-010119-t1x9gknd 3217 5 evaluated evaluate VBN cord-010119-t1x9gknd 3217 6 MSC MSC NNP cord-010119-t1x9gknd 3217 7 - - HYPH cord-010119-t1x9gknd 3217 8 therapy therapy NN cord-010119-t1x9gknd 3217 9 as as IN cord-010119-t1x9gknd 3217 10 an an DT cord-010119-t1x9gknd 3217 11 effective effective JJ cord-010119-t1x9gknd 3217 12 treatment treatment NN cord-010119-t1x9gknd 3217 13 of of IN cord-010119-t1x9gknd 3217 14 GvHD GvHD NNP cord-010119-t1x9gknd 3217 15 in in IN cord-010119-t1x9gknd 3217 16 the the DT cord-010119-t1x9gknd 3217 17 majority majority NN cord-010119-t1x9gknd 3217 18 of of IN cord-010119-t1x9gknd 3217 19 the the DT cord-010119-t1x9gknd 3217 20 observed observed JJ cord-010119-t1x9gknd 3217 21 cases case NNS cord-010119-t1x9gknd 3217 22 with with IN cord-010119-t1x9gknd 3217 23 83 83 CD cord-010119-t1x9gknd 3217 24 % % NN cord-010119-t1x9gknd 3217 25 overall overall JJ cord-010119-t1x9gknd 3217 26 cumulative cumulative JJ cord-010119-t1x9gknd 3217 27 response response NN cord-010119-t1x9gknd 3217 28 rate rate NN cord-010119-t1x9gknd 3217 29 . . . cord-010119-t1x9gknd 3218 1 The the DT cord-010119-t1x9gknd 3218 2 application application NN cord-010119-t1x9gknd 3218 3 of of IN cord-010119-t1x9gknd 3218 4 third third JJ cord-010119-t1x9gknd 3218 5 - - HYPH cord-010119-t1x9gknd 3218 6 party party NN cord-010119-t1x9gknd 3218 7 MSCs mscs NN cord-010119-t1x9gknd 3218 8 offers offer VBZ cord-010119-t1x9gknd 3218 9 a a DT cord-010119-t1x9gknd 3218 10 promising promising JJ cord-010119-t1x9gknd 3218 11 alternative alternative NN cord-010119-t1x9gknd 3218 12 in in IN cord-010119-t1x9gknd 3218 13 the the DT cord-010119-t1x9gknd 3218 14 therapy therapy NN cord-010119-t1x9gknd 3218 15 of of IN cord-010119-t1x9gknd 3218 16 GvHD GvHD NNP cord-010119-t1x9gknd 3218 17 and and CC cord-010119-t1x9gknd 3218 18 other other JJ cord-010119-t1x9gknd 3218 19 GvHD gvhd NN cord-010119-t1x9gknd 3218 20 - - HYPH cord-010119-t1x9gknd 3218 21 associated associate VBN cord-010119-t1x9gknd 3218 22 complications complication NNS cord-010119-t1x9gknd 3218 23 after after IN cord-010119-t1x9gknd 3218 24 HSCT HSCT NNP cord-010119-t1x9gknd 3218 25 . . . cord-010119-t1x9gknd 3219 1 Further further JJ cord-010119-t1x9gknd 3219 2 research research NN cord-010119-t1x9gknd 3219 3 is be VBZ cord-010119-t1x9gknd 3219 4 needed need VBN cord-010119-t1x9gknd 3219 5 to to TO cord-010119-t1x9gknd 3219 6 determine determine VB cord-010119-t1x9gknd 3219 7 the the DT cord-010119-t1x9gknd 3219 8 optimal optimal JJ cord-010119-t1x9gknd 3219 9 start start NN cord-010119-t1x9gknd 3219 10 of of IN cord-010119-t1x9gknd 3219 11 the the DT cord-010119-t1x9gknd 3219 12 treatment treatment NN cord-010119-t1x9gknd 3219 13 , , , cord-010119-t1x9gknd 3219 14 along along IN cord-010119-t1x9gknd 3219 15 with with IN cord-010119-t1x9gknd 3219 16 the the DT cord-010119-t1x9gknd 3219 17 issue issue NN cord-010119-t1x9gknd 3219 18 of of IN cord-010119-t1x9gknd 3219 19 long long JJ cord-010119-t1x9gknd 3219 20 - - HYPH cord-010119-t1x9gknd 3219 21 term term NN cord-010119-t1x9gknd 3219 22 safety safety NN cord-010119-t1x9gknd 3219 23 . . . cord-010119-t1x9gknd 3220 1 Background Background NNP cord-010119-t1x9gknd 3220 2 / / SYM cord-010119-t1x9gknd 3220 3 Case Case NNP cord-010119-t1x9gknd 3220 4 Studies Studies NNPS cord-010119-t1x9gknd 3220 5 : : : cord-010119-t1x9gknd 3220 6 Stem stem JJ cord-010119-t1x9gknd 3220 7 cell cell NN cord-010119-t1x9gknd 3220 8 collection collection NN cord-010119-t1x9gknd 3220 9 by by IN cord-010119-t1x9gknd 3220 10 leukapheresis leukapheresis NN cord-010119-t1x9gknd 3220 11 for for IN cord-010119-t1x9gknd 3220 12 transplantation transplantation NN cord-010119-t1x9gknd 3220 13 is be VBZ cord-010119-t1x9gknd 3220 14 a a DT cord-010119-t1x9gknd 3220 15 significant significant JJ cord-010119-t1x9gknd 3220 16 endeavor endeavor NN cord-010119-t1x9gknd 3220 17 for for IN cord-010119-t1x9gknd 3220 18 the the DT cord-010119-t1x9gknd 3220 19 patient patient NN cord-010119-t1x9gknd 3220 20 and and CC cord-010119-t1x9gknd 3220 21 the the DT cord-010119-t1x9gknd 3220 22 clinical clinical JJ cord-010119-t1x9gknd 3220 23 team team NN cord-010119-t1x9gknd 3220 24 . . . cord-010119-t1x9gknd 3221 1 Whether whether IN cord-010119-t1x9gknd 3221 2 the the DT cord-010119-t1x9gknd 3221 3 collection collection NN cord-010119-t1x9gknd 3221 4 is be VBZ cord-010119-t1x9gknd 3221 5 allogenic allogenic JJ cord-010119-t1x9gknd 3221 6 or or CC cord-010119-t1x9gknd 3221 7 autologous autologous JJ cord-010119-t1x9gknd 3221 8 , , , cord-010119-t1x9gknd 3221 9 the the DT cord-010119-t1x9gknd 3221 10 patient patient NN cord-010119-t1x9gknd 3221 11 undergoing undergo VBG cord-010119-t1x9gknd 3221 12 the the DT cord-010119-t1x9gknd 3221 13 collection collection NN cord-010119-t1x9gknd 3221 14 and and CC cord-010119-t1x9gknd 3221 15 the the DT cord-010119-t1x9gknd 3221 16 physicians physician NNS cord-010119-t1x9gknd 3221 17 caring care VBG cord-010119-t1x9gknd 3221 18 for for IN cord-010119-t1x9gknd 3221 19 the the DT cord-010119-t1x9gknd 3221 20 patient patient NN cord-010119-t1x9gknd 3221 21 are be VBP cord-010119-t1x9gknd 3221 22 always always RB cord-010119-t1x9gknd 3221 23 concerned concerned JJ cord-010119-t1x9gknd 3221 24 whether whether IN cord-010119-t1x9gknd 3221 25 they -PRON- PRP cord-010119-t1x9gknd 3221 26 will will MD cord-010119-t1x9gknd 3221 27 be be VB cord-010119-t1x9gknd 3221 28 able able JJ cord-010119-t1x9gknd 3221 29 to to TO cord-010119-t1x9gknd 3221 30 harvest harvest VB cord-010119-t1x9gknd 3221 31 enough enough JJ cord-010119-t1x9gknd 3221 32 cells cell NNS cord-010119-t1x9gknd 3221 33 for for IN cord-010119-t1x9gknd 3221 34 transplantation transplantation NN cord-010119-t1x9gknd 3221 35 and and CC cord-010119-t1x9gknd 3221 36 engraftment engraftment NN cord-010119-t1x9gknd 3221 37 . . . cord-010119-t1x9gknd 3222 1 A a DT cord-010119-t1x9gknd 3222 2 typical typical JJ cord-010119-t1x9gknd 3222 3 goal goal NN cord-010119-t1x9gknd 3222 4 for for IN cord-010119-t1x9gknd 3222 5 most most JJS cord-010119-t1x9gknd 3222 6 adult adult NN cord-010119-t1x9gknd 3222 7 procedures procedure NNS cord-010119-t1x9gknd 3222 8 is be VBZ cord-010119-t1x9gknd 3222 9 2 2 CD cord-010119-t1x9gknd 3222 10 million million CD cord-010119-t1x9gknd 3222 11 CD341 cd341 NN cord-010119-t1x9gknd 3222 12 cells cell NNS cord-010119-t1x9gknd 3222 13 / / SYM cord-010119-t1x9gknd 3222 14 kg kg NNS cord-010119-t1x9gknd 3222 15 . . . cord-010119-t1x9gknd 3223 1 If if IN cord-010119-t1x9gknd 3223 2 a a DT cord-010119-t1x9gknd 3223 3 patient patient NN cord-010119-t1x9gknd 3223 4 does do VBZ cord-010119-t1x9gknd 3223 5 not not RB cord-010119-t1x9gknd 3223 6 reach reach VB cord-010119-t1x9gknd 3223 7 this this DT cord-010119-t1x9gknd 3223 8 goal goal NN cord-010119-t1x9gknd 3223 9 on on IN cord-010119-t1x9gknd 3223 10 the the DT cord-010119-t1x9gknd 3223 11 day day NN cord-010119-t1x9gknd 3223 12 of of IN cord-010119-t1x9gknd 3223 13 the the DT cord-010119-t1x9gknd 3223 14 procedure procedure NN cord-010119-t1x9gknd 3223 15 , , , cord-010119-t1x9gknd 3223 16 they -PRON- PRP cord-010119-t1x9gknd 3223 17 will will MD cord-010119-t1x9gknd 3223 18 likely likely RB cord-010119-t1x9gknd 3223 19 have have VB cord-010119-t1x9gknd 3223 20 to to TO cord-010119-t1x9gknd 3223 21 return return VB cord-010119-t1x9gknd 3223 22 the the DT cord-010119-t1x9gknd 3223 23 following following JJ cord-010119-t1x9gknd 3223 24 day day NN cord-010119-t1x9gknd 3223 25 to to TO cord-010119-t1x9gknd 3223 26 undergo undergo VB cord-010119-t1x9gknd 3223 27 a a DT cord-010119-t1x9gknd 3223 28 second second JJ cord-010119-t1x9gknd 3223 29 procedure procedure NN cord-010119-t1x9gknd 3223 30 to to TO cord-010119-t1x9gknd 3223 31 reach reach VB cord-010119-t1x9gknd 3223 32 the the DT cord-010119-t1x9gknd 3223 33 desired desire VBN cord-010119-t1x9gknd 3223 34 goal goal NN cord-010119-t1x9gknd 3223 35 . . . cord-010119-t1x9gknd 3224 1 Given give VBN cord-010119-t1x9gknd 3224 2 the the DT cord-010119-t1x9gknd 3224 3 logistical logistical JJ cord-010119-t1x9gknd 3224 4 challenges challenge NNS cord-010119-t1x9gknd 3224 5 in in IN cord-010119-t1x9gknd 3224 6 planning plan VBG cord-010119-t1x9gknd 3224 7 transplantation transplantation NN cord-010119-t1x9gknd 3224 8 , , , cord-010119-t1x9gknd 3224 9 it -PRON- PRP cord-010119-t1x9gknd 3224 10 is be VBZ cord-010119-t1x9gknd 3224 11 reasonable reasonable JJ cord-010119-t1x9gknd 3224 12 to to TO cord-010119-t1x9gknd 3224 13 attempt attempt VB cord-010119-t1x9gknd 3224 14 to to TO cord-010119-t1x9gknd 3224 15 optimize optimize VB cord-010119-t1x9gknd 3224 16 the the DT cord-010119-t1x9gknd 3224 17 number number NN cord-010119-t1x9gknd 3224 18 of of IN cord-010119-t1x9gknd 3224 19 cells cell NNS cord-010119-t1x9gknd 3224 20 collected collect VBN cord-010119-t1x9gknd 3224 21 while while IN cord-010119-t1x9gknd 3224 22 minimizing minimize VBG cord-010119-t1x9gknd 3224 23 the the DT cord-010119-t1x9gknd 3224 24 number number NN cord-010119-t1x9gknd 3224 25 of of IN cord-010119-t1x9gknd 3224 26 collections collection NNS cord-010119-t1x9gknd 3224 27 . . . cord-010119-t1x9gknd 3225 1 Measuring measure VBG cord-010119-t1x9gknd 3225 2 a a DT cord-010119-t1x9gknd 3225 3 patient patient NN cord-010119-t1x9gknd 3225 4 's 's POS cord-010119-t1x9gknd 3225 5 CD341 cd341 NN cord-010119-t1x9gknd 3225 6 cells cell NNS cord-010119-t1x9gknd 3225 7 / / SYM cord-010119-t1x9gknd 3225 8 mL ml NN cord-010119-t1x9gknd 3225 9 in in IN cord-010119-t1x9gknd 3225 10 their -PRON- PRP$ cord-010119-t1x9gknd 3225 11 peripheral peripheral JJ cord-010119-t1x9gknd 3225 12 blood blood NN cord-010119-t1x9gknd 3225 13 before before IN cord-010119-t1x9gknd 3225 14 the the DT cord-010119-t1x9gknd 3225 15 leukapheresis leukapheresis NN cord-010119-t1x9gknd 3225 16 procedure procedure NN cord-010119-t1x9gknd 3225 17 has have VBZ cord-010119-t1x9gknd 3225 18 been be VBN cord-010119-t1x9gknd 3225 19 used use VBN cord-010119-t1x9gknd 3225 20 to to TO cord-010119-t1x9gknd 3225 21 predict predict VB cord-010119-t1x9gknd 3225 22 if if IN cord-010119-t1x9gknd 3225 23 the the DT cord-010119-t1x9gknd 3225 24 collection collection NN cord-010119-t1x9gknd 3225 25 will will MD cord-010119-t1x9gknd 3225 26 successfully successfully RB cord-010119-t1x9gknd 3225 27 reach reach VB cord-010119-t1x9gknd 3225 28 the the DT cord-010119-t1x9gknd 3225 29 2 2 CD cord-010119-t1x9gknd 3225 30 million million CD cord-010119-t1x9gknd 3225 31 cells cell NNS cord-010119-t1x9gknd 3225 32 / / SYM cord-010119-t1x9gknd 3225 33 kg kg NN cord-010119-t1x9gknd 3225 34 goal goal NN cord-010119-t1x9gknd 3225 35 . . . cord-010119-t1x9gknd 3226 1 The the DT cord-010119-t1x9gknd 3226 2 ideal ideal JJ cord-010119-t1x9gknd 3226 3 minimum minimum NN cord-010119-t1x9gknd 3226 4 CD341 cd341 NN cord-010119-t1x9gknd 3226 5 cells cell NNS cord-010119-t1x9gknd 3226 6 / / SYM cord-010119-t1x9gknd 3226 7 mL ml NN cord-010119-t1x9gknd 3226 8 that that WDT cord-010119-t1x9gknd 3226 9 will will MD cord-010119-t1x9gknd 3226 10 lead lead VB cord-010119-t1x9gknd 3226 11 to to IN cord-010119-t1x9gknd 3226 12 successful successful JJ cord-010119-t1x9gknd 3226 13 harvest harvest NN cord-010119-t1x9gknd 3226 14 has have VBZ cord-010119-t1x9gknd 3226 15 not not RB cord-010119-t1x9gknd 3226 16 been be VBN cord-010119-t1x9gknd 3226 17 conclusively conclusively RB cord-010119-t1x9gknd 3226 18 identified identify VBN cord-010119-t1x9gknd 3226 19 . . . cord-010119-t1x9gknd 3227 1 Study Study NNP cord-010119-t1x9gknd 3227 2 Design Design NNP cord-010119-t1x9gknd 3227 3 / / SYM cord-010119-t1x9gknd 3227 4 Methods method NNS cord-010119-t1x9gknd 3228 1 : : : cord-010119-t1x9gknd 3228 2 We -PRON- PRP cord-010119-t1x9gknd 3228 3 analyzed analyze VBD cord-010119-t1x9gknd 3228 4 the the DT cord-010119-t1x9gknd 3228 5 collection collection NN cord-010119-t1x9gknd 3228 6 data datum NNS cord-010119-t1x9gknd 3228 7 from from IN cord-010119-t1x9gknd 3228 8 55 55 CD cord-010119-t1x9gknd 3228 9 patients patient NNS cord-010119-t1x9gknd 3228 10 to to TO cord-010119-t1x9gknd 3228 11 evaluate evaluate VB cord-010119-t1x9gknd 3228 12 the the DT cord-010119-t1x9gknd 3228 13 predictive predictive JJ cord-010119-t1x9gknd 3228 14 value value NN cord-010119-t1x9gknd 3228 15 of of IN cord-010119-t1x9gknd 3228 16 the the DT cord-010119-t1x9gknd 3228 17 CD341 cd341 NN cord-010119-t1x9gknd 3228 18 cells cell NNS cord-010119-t1x9gknd 3228 19 / / SYM cord-010119-t1x9gknd 3228 20 mL ml NN cord-010119-t1x9gknd 3228 21 level level NN cord-010119-t1x9gknd 3228 22 . . . cord-010119-t1x9gknd 3229 1 Data datum NNS cord-010119-t1x9gknd 3229 2 was be VBD cord-010119-t1x9gknd 3229 3 collected collect VBN cord-010119-t1x9gknd 3229 4 over over IN cord-010119-t1x9gknd 3229 5 6 6 CD cord-010119-t1x9gknd 3229 6 months month NNS cord-010119-t1x9gknd 3229 7 from from IN cord-010119-t1x9gknd 3229 8 every every DT cord-010119-t1x9gknd 3229 9 patient patient NN cord-010119-t1x9gknd 3229 10 who who WP cord-010119-t1x9gknd 3229 11 underwent undergo VBD cord-010119-t1x9gknd 3229 12 a a DT cord-010119-t1x9gknd 3229 13 stem stem NN cord-010119-t1x9gknd 3229 14 cell cell NN cord-010119-t1x9gknd 3229 15 collection collection NN cord-010119-t1x9gknd 3229 16 . . . cord-010119-t1x9gknd 3230 1 Four four CD cord-010119-t1x9gknd 3230 2 patients patient NNS cord-010119-t1x9gknd 3230 3 were be VBD cord-010119-t1x9gknd 3230 4 allogenic allogenic JJ cord-010119-t1x9gknd 3230 5 donors donor NNS cord-010119-t1x9gknd 3230 6 and and CC cord-010119-t1x9gknd 3230 7 51 51 CD cord-010119-t1x9gknd 3230 8 were be VBD cord-010119-t1x9gknd 3230 9 autologous autologous JJ cord-010119-t1x9gknd 3230 10 donors donor NNS cord-010119-t1x9gknd 3230 11 . . . cord-010119-t1x9gknd 3231 1 The the DT cord-010119-t1x9gknd 3231 2 patients patient NNS cord-010119-t1x9gknd 3231 3 ' ' POS cord-010119-t1x9gknd 3231 4 weight weight NN cord-010119-t1x9gknd 3231 5 , , , cord-010119-t1x9gknd 3231 6 diagnosis diagnosis NN cord-010119-t1x9gknd 3231 7 , , , cord-010119-t1x9gknd 3231 8 and and CC cord-010119-t1x9gknd 3231 9 pre pre JJ cord-010119-t1x9gknd 3231 10 - - JJ cord-010119-t1x9gknd 3231 11 procedure procedure JJ cord-010119-t1x9gknd 3231 12 CD341 cd341 NN cord-010119-t1x9gknd 3231 13 cells cell NNS cord-010119-t1x9gknd 3231 14 / / SYM cord-010119-t1x9gknd 3231 15 mL ml NN cord-010119-t1x9gknd 3231 16 level level NN cord-010119-t1x9gknd 3231 17 were be VBD cord-010119-t1x9gknd 3231 18 all all DT cord-010119-t1x9gknd 3231 19 collected collect VBN cord-010119-t1x9gknd 3231 20 . . . cord-010119-t1x9gknd 3232 1 The the DT cord-010119-t1x9gknd 3232 2 run run NN cord-010119-t1x9gknd 3232 3 time time NN cord-010119-t1x9gknd 3232 4 , , , cord-010119-t1x9gknd 3232 5 amount amount NN cord-010119-t1x9gknd 3232 6 of of IN cord-010119-t1x9gknd 3232 7 volume volume NN cord-010119-t1x9gknd 3232 8 processed process VBN cord-010119-t1x9gknd 3232 9 , , , cord-010119-t1x9gknd 3232 10 and and CC cord-010119-t1x9gknd 3232 11 the the DT cord-010119-t1x9gknd 3232 12 absolute absolute JJ cord-010119-t1x9gknd 3232 13 viable viable JJ cord-010119-t1x9gknd 3232 14 CD341 cd341 NN cord-010119-t1x9gknd 3232 15 cells cell NNS cord-010119-t1x9gknd 3232 16 collected collect VBN cord-010119-t1x9gknd 3232 17 were be VBD cord-010119-t1x9gknd 3232 18 recorded record VBN cord-010119-t1x9gknd 3232 19 . . . cord-010119-t1x9gknd 3233 1 The the DT cord-010119-t1x9gknd 3233 2 collection collection NN cord-010119-t1x9gknd 3233 3 efficiency efficiency NN cord-010119-t1x9gknd 3233 4 and and CC cord-010119-t1x9gknd 3233 5 the the DT cord-010119-t1x9gknd 3233 6 CD341 cd341 NN cord-010119-t1x9gknd 3233 7 cells cell NNS cord-010119-t1x9gknd 3233 8 / / SYM cord-010119-t1x9gknd 3233 9 kg kg NNS cord-010119-t1x9gknd 3233 10 were be VBD cord-010119-t1x9gknd 3233 11 calculated calculate VBN cord-010119-t1x9gknd 3233 12 for for IN cord-010119-t1x9gknd 3233 13 each each DT cord-010119-t1x9gknd 3233 14 patient patient NN cord-010119-t1x9gknd 3233 15 . . . cord-010119-t1x9gknd 3234 1 Results result NNS cord-010119-t1x9gknd 3234 2 / / SYM cord-010119-t1x9gknd 3234 3 Findings finding NNS cord-010119-t1x9gknd 3234 4 : : : cord-010119-t1x9gknd 3235 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3235 2 data datum NNS cord-010119-t1x9gknd 3235 3 showed show VBD cord-010119-t1x9gknd 3235 4 a a DT cord-010119-t1x9gknd 3235 5 strong strong JJ cord-010119-t1x9gknd 3235 6 linear linear JJ cord-010119-t1x9gknd 3235 7 correlation correlation NN cord-010119-t1x9gknd 3235 8 between between IN cord-010119-t1x9gknd 3235 9 pre pre JJ cord-010119-t1x9gknd 3235 10 - - JJ cord-010119-t1x9gknd 3235 11 procedure procedure JJ cord-010119-t1x9gknd 3235 12 CD341 cd341 NN cord-010119-t1x9gknd 3235 13 cells cell NNS cord-010119-t1x9gknd 3235 14 / / SYM cord-010119-t1x9gknd 3235 15 mL ml NN cord-010119-t1x9gknd 3235 16 and and CC cord-010119-t1x9gknd 3235 17 post post JJ cord-010119-t1x9gknd 3235 18 - - NN cord-010119-t1x9gknd 3235 19 procedure procedure JJ cord-010119-t1x9gknd 3236 1 CD341 CD341 NNP cord-010119-t1x9gknd 3236 2 cells cell NNS cord-010119-t1x9gknd 3236 3 / / SYM cord-010119-t1x9gknd 3236 4 kg kg NN cord-010119-t1x9gknd 3236 5 ( ( -LRB- cord-010119-t1x9gknd 3236 6 r50.95 r50.95 NNP cord-010119-t1x9gknd 3236 7 ) ) -RRB- cord-010119-t1x9gknd 3236 8 . . . cord-010119-t1x9gknd 3237 1 Any any DT cord-010119-t1x9gknd 3237 2 patient patient NN cord-010119-t1x9gknd 3237 3 who who WP cord-010119-t1x9gknd 3237 4 had have VBD cord-010119-t1x9gknd 3237 5 a a DT cord-010119-t1x9gknd 3237 6 pre pre JJ cord-010119-t1x9gknd 3237 7 - - JJ cord-010119-t1x9gknd 3237 8 procedure procedure JJ cord-010119-t1x9gknd 3237 9 CD341 cd341 NN cord-010119-t1x9gknd 3237 10 cells cell NNS cord-010119-t1x9gknd 3237 11 / / SYM cord-010119-t1x9gknd 3237 12 mL ml NN cord-010119-t1x9gknd 3237 13 count count NN cord-010119-t1x9gknd 3237 14 of of IN cord-010119-t1x9gknd 3237 15 29 29 CD cord-010119-t1x9gknd 3237 16 or or CC cord-010119-t1x9gknd 3237 17 greater great JJR cord-010119-t1x9gknd 3237 18 had have VBD cord-010119-t1x9gknd 3237 19 a a DT cord-010119-t1x9gknd 3237 20 collection collection NN cord-010119-t1x9gknd 3237 21 of of IN cord-010119-t1x9gknd 3237 22 at at RB cord-010119-t1x9gknd 3237 23 least least JJS cord-010119-t1x9gknd 3237 24 2 2 CD cord-010119-t1x9gknd 3237 25 million million CD cord-010119-t1x9gknd 3237 26 cells cell NNS cord-010119-t1x9gknd 3237 27 / / SYM cord-010119-t1x9gknd 3237 28 kg kg NNS cord-010119-t1x9gknd 3237 29 . . . cord-010119-t1x9gknd 3238 1 Any any DT cord-010119-t1x9gknd 3238 2 patient patient NN cord-010119-t1x9gknd 3238 3 who who WP cord-010119-t1x9gknd 3238 4 had have VBD cord-010119-t1x9gknd 3238 5 a a DT cord-010119-t1x9gknd 3238 6 pre pre JJ cord-010119-t1x9gknd 3238 7 - - JJ cord-010119-t1x9gknd 3238 8 procedure procedure JJ cord-010119-t1x9gknd 3238 9 CD341 cd341 NN cord-010119-t1x9gknd 3238 10 cells cell NNS cord-010119-t1x9gknd 3238 11 / / SYM cord-010119-t1x9gknd 3238 12 mL ml NN cord-010119-t1x9gknd 3238 13 count count NN cord-010119-t1x9gknd 3238 14 of of IN cord-010119-t1x9gknd 3238 15 16 16 CD cord-010119-t1x9gknd 3238 16 or or CC cord-010119-t1x9gknd 3238 17 less less RBR cord-010119-t1x9gknd 3238 18 collected collect VBN cord-010119-t1x9gknd 3238 19 less less JJR cord-010119-t1x9gknd 3238 20 than than IN cord-010119-t1x9gknd 3238 21 2 2 CD cord-010119-t1x9gknd 3238 22 Conclusion conclusion NN cord-010119-t1x9gknd 3238 23 : : : cord-010119-t1x9gknd 3238 24 The the DT cord-010119-t1x9gknd 3238 25 pre pre JJ cord-010119-t1x9gknd 3238 26 - - JJ cord-010119-t1x9gknd 3238 27 procedure procedure JJ cord-010119-t1x9gknd 3238 28 CD341 cd341 NN cord-010119-t1x9gknd 3238 29 cells cell NNS cord-010119-t1x9gknd 3238 30 / / SYM cord-010119-t1x9gknd 3238 31 mL ml NN cord-010119-t1x9gknd 3238 32 level level NN cord-010119-t1x9gknd 3238 33 in in IN cord-010119-t1x9gknd 3238 34 the the DT cord-010119-t1x9gknd 3238 35 peripheral peripheral JJ cord-010119-t1x9gknd 3238 36 blood blood NN cord-010119-t1x9gknd 3238 37 has have VBZ cord-010119-t1x9gknd 3238 38 a a DT cord-010119-t1x9gknd 3238 39 very very RB cord-010119-t1x9gknd 3238 40 strong strong JJ cord-010119-t1x9gknd 3238 41 predictive predictive JJ cord-010119-t1x9gknd 3238 42 value value NN cord-010119-t1x9gknd 3238 43 for for IN cord-010119-t1x9gknd 3238 44 the the DT cord-010119-t1x9gknd 3238 45 post post JJ cord-010119-t1x9gknd 3238 46 - - JJ cord-010119-t1x9gknd 3238 47 procedure procedure JJ cord-010119-t1x9gknd 3238 48 CD341 cd341 NN cord-010119-t1x9gknd 3238 49 cells cell NNS cord-010119-t1x9gknd 3238 50 / / SYM cord-010119-t1x9gknd 3238 51 kg kg NN cord-010119-t1x9gknd 3238 52 level level NN cord-010119-t1x9gknd 3238 53 . . . cord-010119-t1x9gknd 3239 1 To to TO cord-010119-t1x9gknd 3239 2 confidently confidently RB cord-010119-t1x9gknd 3239 3 know know VB cord-010119-t1x9gknd 3239 4 that that IN cord-010119-t1x9gknd 3239 5 a a DT cord-010119-t1x9gknd 3239 6 patient patient NN cord-010119-t1x9gknd 3239 7 will will MD cord-010119-t1x9gknd 3239 8 be be VB cord-010119-t1x9gknd 3239 9 able able JJ cord-010119-t1x9gknd 3239 10 to to TO cord-010119-t1x9gknd 3239 11 produce produce VB cord-010119-t1x9gknd 3239 12 the the DT cord-010119-t1x9gknd 3239 13 desired desire VBN cord-010119-t1x9gknd 3239 14 2 2 CD cord-010119-t1x9gknd 3239 15 million million CD cord-010119-t1x9gknd 3239 16 cells cell NNS cord-010119-t1x9gknd 3239 17 / / SYM cord-010119-t1x9gknd 3239 18 kg kg NNS cord-010119-t1x9gknd 3239 19 , , , cord-010119-t1x9gknd 3239 20 a a DT cord-010119-t1x9gknd 3239 21 pre pre JJ cord-010119-t1x9gknd 3239 22 - - JJ cord-010119-t1x9gknd 3239 23 procedure procedure JJ cord-010119-t1x9gknd 3239 24 CD341 cd341 NN cord-010119-t1x9gknd 3239 25 cells cell NNS cord-010119-t1x9gknd 3239 26 / / SYM cord-010119-t1x9gknd 3239 27 mL ml NN cord-010119-t1x9gknd 3239 28 count count NN cord-010119-t1x9gknd 3239 29 of of IN cord-010119-t1x9gknd 3239 30 at at RB cord-010119-t1x9gknd 3239 31 least least RBS cord-010119-t1x9gknd 3239 32 29 29 CD cord-010119-t1x9gknd 3239 33 should should MD cord-010119-t1x9gknd 3239 34 be be VB cord-010119-t1x9gknd 3239 35 obtained obtain VBN cord-010119-t1x9gknd 3239 36 . . . cord-010119-t1x9gknd 3240 1 For for IN cord-010119-t1x9gknd 3240 2 any any DT cord-010119-t1x9gknd 3240 3 patient patient NN cord-010119-t1x9gknd 3240 4 with with IN cord-010119-t1x9gknd 3240 5 a a DT cord-010119-t1x9gknd 3240 6 count count NN cord-010119-t1x9gknd 3240 7 below below IN cord-010119-t1x9gknd 3240 8 16 16 CD cord-010119-t1x9gknd 3240 9 , , , cord-010119-t1x9gknd 3240 10 they -PRON- PRP cord-010119-t1x9gknd 3240 11 should should MD cord-010119-t1x9gknd 3240 12 be be VB cord-010119-t1x9gknd 3240 13 counseled counsel VBN cord-010119-t1x9gknd 3240 14 that that IN cord-010119-t1x9gknd 3240 15 their -PRON- PRP$ cord-010119-t1x9gknd 3240 16 collection collection NN cord-010119-t1x9gknd 3240 17 is be VBZ cord-010119-t1x9gknd 3240 18 likely likely JJ cord-010119-t1x9gknd 3240 19 to to TO cord-010119-t1x9gknd 3240 20 take take VB cord-010119-t1x9gknd 3240 21 at at RB cord-010119-t1x9gknd 3240 22 least least JJS cord-010119-t1x9gknd 3240 23 a a DT cord-010119-t1x9gknd 3240 24 second second JJ cord-010119-t1x9gknd 3240 25 day day NN cord-010119-t1x9gknd 3240 26 and and CC cord-010119-t1x9gknd 3240 27 a a DT cord-010119-t1x9gknd 3240 28 second second JJ cord-010119-t1x9gknd 3240 29 procedure procedure NN cord-010119-t1x9gknd 3240 30 . . . cord-010119-t1x9gknd 3241 1 Further further JJ cord-010119-t1x9gknd 3241 2 studies study NNS cord-010119-t1x9gknd 3241 3 , , , cord-010119-t1x9gknd 3241 4 including include VBG cord-010119-t1x9gknd 3241 5 potentially potentially RB cord-010119-t1x9gknd 3241 6 lengthening lengthen VBG cord-010119-t1x9gknd 3241 7 the the DT cord-010119-t1x9gknd 3241 8 run run NN cord-010119-t1x9gknd 3241 9 time time NN cord-010119-t1x9gknd 3241 10 and and CC cord-010119-t1x9gknd 3241 11 the the DT cord-010119-t1x9gknd 3241 12 volume volume NN cord-010119-t1x9gknd 3241 13 processed process VBN cord-010119-t1x9gknd 3241 14 , , , cord-010119-t1x9gknd 3241 15 to to TO cord-010119-t1x9gknd 3241 16 evaluate evaluate VB cord-010119-t1x9gknd 3241 17 how how WRB cord-010119-t1x9gknd 3241 18 to to TO cord-010119-t1x9gknd 3241 19 handle handle VB cord-010119-t1x9gknd 3241 20 the the DT cord-010119-t1x9gknd 3241 21 patients patient NNS cord-010119-t1x9gknd 3241 22 who who WP cord-010119-t1x9gknd 3241 23 fall fall VBP cord-010119-t1x9gknd 3241 24 between between IN cord-010119-t1x9gknd 3241 25 16 16 CD cord-010119-t1x9gknd 3241 26 and and CC cord-010119-t1x9gknd 3241 27 29 29 CD cord-010119-t1x9gknd 3241 28 CD341 cd341 NN cord-010119-t1x9gknd 3241 29 cells cell NNS cord-010119-t1x9gknd 3241 30 / / SYM cord-010119-t1x9gknd 3241 31 mL ml NN cord-010119-t1x9gknd 3241 32 should should MD cord-010119-t1x9gknd 3241 33 be be VB cord-010119-t1x9gknd 3241 34 conducted conduct VBN cord-010119-t1x9gknd 3241 35 . . . cord-010119-t1x9gknd 3242 1 Heidi Heidi NNP cord-010119-t1x9gknd 3242 2 Elmoazzen Elmoazzen NNP cord-010119-t1x9gknd 3242 3 1 1 CD cord-010119-t1x9gknd 3242 4 , , , cord-010119-t1x9gknd 3242 5 Antonio Antonio NNP cord-010119-t1x9gknd 3242 6 Giulivi Giulivi NNP cord-010119-t1x9gknd 3242 7 1 1 CD cord-010119-t1x9gknd 3242 8 , , , cord-010119-t1x9gknd 3242 9 Michael Michael NNP cord-010119-t1x9gknd 3242 10 Halpenny Halpenny NNP cord-010119-t1x9gknd 3242 11 * * NFP cord-010119-t1x9gknd 3242 12 1 1 CD cord-010119-t1x9gknd 3242 13 , , , cord-010119-t1x9gknd 3242 14 Lisa Lisa NNP cord-010119-t1x9gknd 3242 15 Martin Martin NNP cord-010119-t1x9gknd 3242 16 1 1 CD cord-010119-t1x9gknd 3242 17 , , , cord-010119-t1x9gknd 3242 18 Donna Donna NNP cord-010119-t1x9gknd 3242 19 Perron Perron NNP cord-010119-t1x9gknd 3242 20 1 1 CD cord-010119-t1x9gknd 3242 21 , , , cord-010119-t1x9gknd 3242 22 Chris Chris NNP cord-010119-t1x9gknd 3242 23 Bredeson Bredeson NNP cord-010119-t1x9gknd 3242 24 2 2 CD cord-010119-t1x9gknd 3242 25 , , , cord-010119-t1x9gknd 3242 26 Lin Lin NNP cord-010119-t1x9gknd 3242 27 Yang Yang NNP cord-010119-t1x9gknd 3242 28 1 1 CD cord-010119-t1x9gknd 3242 29 , , , cord-010119-t1x9gknd 3242 30 Locksley Locksley NNP cord-010119-t1x9gknd 3242 31 McGann McGann NNP cord-010119-t1x9gknd 3242 32 1 1 CD cord-010119-t1x9gknd 3242 33 , , , cord-010119-t1x9gknd 3242 34 Paul Paul NNP cord-010119-t1x9gknd 3242 35 Birch Birch NNP cord-010119-t1x9gknd 3242 36 1 1 CD cord-010119-t1x9gknd 3242 37 and and CC cord-010119-t1x9gknd 3242 38 Jason Jason NNP cord-010119-t1x9gknd 3242 39 P. P. NNP cord-010119-t1x9gknd 3242 40 Acker Acker NNP cord-010119-t1x9gknd 3242 41 1 1 CD cord-010119-t1x9gknd 3242 42 . . . cord-010119-t1x9gknd 3243 1 1 1 CD cord-010119-t1x9gknd 3243 2 Canadian Canadian NNP cord-010119-t1x9gknd 3243 3 Blood Blood NNP cord-010119-t1x9gknd 3243 4 Services Services NNPS cord-010119-t1x9gknd 3243 5 , , , cord-010119-t1x9gknd 3243 6 2 2 CD cord-010119-t1x9gknd 3243 7 Ottawa Ottawa NNP cord-010119-t1x9gknd 3243 8 Hospital Hospital NNP cord-010119-t1x9gknd 3243 9 Background Background NNP cord-010119-t1x9gknd 3243 10 / / SYM cord-010119-t1x9gknd 3243 11 Case Case NNP cord-010119-t1x9gknd 3243 12 Studies Studies NNPS cord-010119-t1x9gknd 3243 13 : : : cord-010119-t1x9gknd 3244 1 A a DT cord-010119-t1x9gknd 3244 2 critical critical JJ cord-010119-t1x9gknd 3244 3 aspect aspect NN cord-010119-t1x9gknd 3244 4 of of IN cord-010119-t1x9gknd 3244 5 Hematopoietic Hematopoietic NNP cord-010119-t1x9gknd 3244 6 Progenitor Progenitor NNP cord-010119-t1x9gknd 3244 7 Cell Cell NNP cord-010119-t1x9gknd 3244 8 processing processing NN cord-010119-t1x9gknd 3244 9 is be VBZ cord-010119-t1x9gknd 3244 10 the the DT cord-010119-t1x9gknd 3244 11 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3244 12 method method NN cord-010119-t1x9gknd 3244 13 . . . cord-010119-t1x9gknd 3245 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3245 2 program program NN cord-010119-t1x9gknd 3245 3 uses use VBZ cord-010119-t1x9gknd 3245 4 a a DT cord-010119-t1x9gknd 3245 5 " " `` cord-010119-t1x9gknd 3245 6 dump dump NN cord-010119-t1x9gknd 3245 7 " " '' cord-010119-t1x9gknd 3245 8 freeze freeze NN cord-010119-t1x9gknd 3245 9 method method NN cord-010119-t1x9gknd 3245 10 consisting consist VBG cord-010119-t1x9gknd 3245 11 of of IN cord-010119-t1x9gknd 3245 12 product product NN cord-010119-t1x9gknd 3245 13 placement placement NN cord-010119-t1x9gknd 3245 14 directly directly RB cord-010119-t1x9gknd 3245 15 into into IN cord-010119-t1x9gknd 3245 16 liquid liquid JJ cord-010119-t1x9gknd 3245 17 nitrogen nitrogen NN cord-010119-t1x9gknd 3245 18 vapour vapour NN cord-010119-t1x9gknd 3245 19 after after IN cord-010119-t1x9gknd 3245 20 addition addition NN cord-010119-t1x9gknd 3245 21 of of IN cord-010119-t1x9gknd 3245 22 a a DT cord-010119-t1x9gknd 3245 23 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3245 24 solution solution NN cord-010119-t1x9gknd 3245 25 containing contain VBG cord-010119-t1x9gknd 3245 26 DMSO DMSO NNP cord-010119-t1x9gknd 3245 27 ( ( -LRB- cord-010119-t1x9gknd 3245 28 5 5 CD cord-010119-t1x9gknd 3245 29 % % NN cord-010119-t1x9gknd 3245 30 final final JJ cord-010119-t1x9gknd 3245 31 concentration concentration NN cord-010119-t1x9gknd 3245 32 ) ) -RRB- cord-010119-t1x9gknd 3245 33 and and CC cord-010119-t1x9gknd 3245 34 HES HES NNP cord-010119-t1x9gknd 3245 35 ( ( -LRB- cord-010119-t1x9gknd 3245 36 Hydroxyethyl Hydroxyethyl NNP cord-010119-t1x9gknd 3245 37 Starch Starch NNP cord-010119-t1x9gknd 3245 38 ) ) -RRB- cord-010119-t1x9gknd 3245 39 . . . cord-010119-t1x9gknd 3246 1 Pentastarch Pentastarch NNP cord-010119-t1x9gknd 3246 2 ( ( -LRB- cord-010119-t1x9gknd 3246 3 HES HES NNP cord-010119-t1x9gknd 3246 4 source source NN cord-010119-t1x9gknd 3246 5 ) ) -RRB- cord-010119-t1x9gknd 3247 1 a a DT cord-010119-t1x9gknd 3247 2 critical critical JJ cord-010119-t1x9gknd 3247 3 component component NN cord-010119-t1x9gknd 3247 4 of of IN cord-010119-t1x9gknd 3247 5 the the DT cord-010119-t1x9gknd 3247 6 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3247 7 formulation formulation NN cord-010119-t1x9gknd 3247 8 was be VBD cord-010119-t1x9gknd 3247 9 discontinued discontinue VBN cord-010119-t1x9gknd 3247 10 by by IN cord-010119-t1x9gknd 3247 11 the the DT cord-010119-t1x9gknd 3247 12 commercial commercial JJ cord-010119-t1x9gknd 3247 13 vendor vendor NN cord-010119-t1x9gknd 3247 14 . . . cord-010119-t1x9gknd 3248 1 This this DT cord-010119-t1x9gknd 3248 2 required require VBD cord-010119-t1x9gknd 3248 3 that that IN cord-010119-t1x9gknd 3248 4 an an DT cord-010119-t1x9gknd 3248 5 alternative alternative JJ cord-010119-t1x9gknd 3248 6 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3248 7 formulation formulation NN cord-010119-t1x9gknd 3248 8 be be VB cord-010119-t1x9gknd 3248 9 validated validate VBN cord-010119-t1x9gknd 3248 10 to to TO cord-010119-t1x9gknd 3248 11 minimize minimize VB cord-010119-t1x9gknd 3248 12 the the DT cord-010119-t1x9gknd 3248 13 risk risk NN cord-010119-t1x9gknd 3248 14 to to IN cord-010119-t1x9gknd 3248 15 patient patient JJ cord-010119-t1x9gknd 3248 16 safety safety NN cord-010119-t1x9gknd 3248 17 without without IN cord-010119-t1x9gknd 3248 18 compromising compromise VBG cord-010119-t1x9gknd 3248 19 engraftment engraftment NN cord-010119-t1x9gknd 3248 20 quality quality NN cord-010119-t1x9gknd 3248 21 . . . cord-010119-t1x9gknd 3249 1 Study Study NNP cord-010119-t1x9gknd 3249 2 Design Design NNP cord-010119-t1x9gknd 3249 3 / / SYM cord-010119-t1x9gknd 3249 4 Method method NN cord-010119-t1x9gknd 3249 5 : : : cord-010119-t1x9gknd 3250 1 The the DT cord-010119-t1x9gknd 3250 2 validation validation NN cord-010119-t1x9gknd 3250 3 study study NN cord-010119-t1x9gknd 3250 4 consisted consist VBD cord-010119-t1x9gknd 3250 5 of of IN cord-010119-t1x9gknd 3250 6 3 3 CD cord-010119-t1x9gknd 3250 7 phases phase NNS cord-010119-t1x9gknd 3250 8 ; ; : cord-010119-t1x9gknd 3251 1 firstevaluation firstevaluation NN cord-010119-t1x9gknd 3251 2 of of IN cord-010119-t1x9gknd 3251 3 the the DT cord-010119-t1x9gknd 3251 4 efficacy efficacy NN cord-010119-t1x9gknd 3251 5 of of IN cord-010119-t1x9gknd 3251 6 four four CD cord-010119-t1x9gknd 3251 7 different different JJ cord-010119-t1x9gknd 3251 8 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3251 9 formulations formulation NNS cord-010119-t1x9gknd 3251 10 , , , cord-010119-t1x9gknd 3251 11 second second JJ cord-010119-t1x9gknd 3251 12 -evaluation -evaluation NN cord-010119-t1x9gknd 3251 13 of of IN cord-010119-t1x9gknd 3251 14 full full JJ cord-010119-t1x9gknd 3251 15 scale scale NN cord-010119-t1x9gknd 3251 16 production production NN cord-010119-t1x9gknd 3251 17 and and CC cord-010119-t1x9gknd 3251 18 crypreservation crypreservation NN cord-010119-t1x9gknd 3251 19 and and CC cord-010119-t1x9gknd 3251 20 third third JJ cord-010119-t1x9gknd 3251 21 -a -a HYPH cord-010119-t1x9gknd 3251 22 concurrent concurrent JJ cord-010119-t1x9gknd 3251 23 validation validation NN cord-010119-t1x9gknd 3251 24 for for IN cord-010119-t1x9gknd 3251 25 clinical clinical JJ cord-010119-t1x9gknd 3251 26 transplant transplant NN cord-010119-t1x9gknd 3251 27 . . . cord-010119-t1x9gknd 3252 1 Phase phase NN cord-010119-t1x9gknd 3252 2 I -PRON- PRP cord-010119-t1x9gknd 3252 3 -Samples -sample VBZ cord-010119-t1x9gknd 3252 4 from from IN cord-010119-t1x9gknd 3252 5 four four CD cord-010119-t1x9gknd 3252 6 different different JJ cord-010119-t1x9gknd 3252 7 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3252 8 formulations formulation NNS cord-010119-t1x9gknd 3252 9 were be VBD cord-010119-t1x9gknd 3252 10 tested test VBN cord-010119-t1x9gknd 3252 11 for for IN cord-010119-t1x9gknd 3252 12 TNC TNC NNP cord-010119-t1x9gknd 3252 13 , , , cord-010119-t1x9gknd 3252 14 CD34 CD34 NNP cord-010119-t1x9gknd 3252 15 , , , cord-010119-t1x9gknd 3252 16 viability viability NN cord-010119-t1x9gknd 3252 17 and and CC cord-010119-t1x9gknd 3252 18 CFU CFU NNP cord-010119-t1x9gknd 3252 19 at at IN cord-010119-t1x9gknd 3252 20 three three CD cord-010119-t1x9gknd 3252 21 points point NNS cord-010119-t1x9gknd 3252 22 during during IN cord-010119-t1x9gknd 3252 23 manufacturing manufacture VBG cord-010119-t1x9gknd 3252 24 ( ( -LRB- cord-010119-t1x9gknd 3252 25 fresh fresh JJ cord-010119-t1x9gknd 3252 26 , , , cord-010119-t1x9gknd 3252 27 post post NN cord-010119-t1x9gknd 3252 28 processing processing NN cord-010119-t1x9gknd 3252 29 and and CC cord-010119-t1x9gknd 3252 30 post post NN cord-010119-t1x9gknd 3252 31 thaw thaw NN cord-010119-t1x9gknd 3252 32 ) ) -RRB- cord-010119-t1x9gknd 3252 33 . . . cord-010119-t1x9gknd 3253 1 Phase phase NN cord-010119-t1x9gknd 3253 2 II ii CD cord-010119-t1x9gknd 3253 3 -Mock -Mock NNP cord-010119-t1x9gknd 3254 1 HPC HPC NNP cord-010119-t1x9gknd 3254 2 , , , cord-010119-t1x9gknd 3254 3 Apheresis Apheresis NNP cord-010119-t1x9gknd 3254 4 units unit NNS cord-010119-t1x9gknd 3254 5 were be VBD cord-010119-t1x9gknd 3254 6 used use VBN cord-010119-t1x9gknd 3254 7 for for IN cord-010119-t1x9gknd 3254 8 a a DT cord-010119-t1x9gknd 3254 9 side side NN cord-010119-t1x9gknd 3254 10 - - HYPH cord-010119-t1x9gknd 3254 11 by by IN cord-010119-t1x9gknd 3254 12 - - HYPH cord-010119-t1x9gknd 3254 13 side side NN cord-010119-t1x9gknd 3254 14 comparison comparison NN cord-010119-t1x9gknd 3254 15 of of IN cord-010119-t1x9gknd 3254 16 freezing freeze VBG cord-010119-t1x9gknd 3254 17 curves curve NNS cord-010119-t1x9gknd 3254 18 for for IN cord-010119-t1x9gknd 3254 19 the the DT cord-010119-t1x9gknd 3254 20 control control NN cord-010119-t1x9gknd 3254 21 and and CC cord-010119-t1x9gknd 3254 22 replacement replacement NN cord-010119-t1x9gknd 3254 23 formulations formulation NNS cord-010119-t1x9gknd 3254 24 . . . cord-010119-t1x9gknd 3255 1 Phase phase NN cord-010119-t1x9gknd 3255 2 III iii CD cord-010119-t1x9gknd 3255 3 -Five -five JJ cord-010119-t1x9gknd 3255 4 clinical clinical JJ cord-010119-t1x9gknd 3255 5 transplants transplant NNS cord-010119-t1x9gknd 3255 6 were be VBD cord-010119-t1x9gknd 3255 7 performed perform VBN cord-010119-t1x9gknd 3255 8 with with IN cord-010119-t1x9gknd 3255 9 HPC HPC NNP cord-010119-t1x9gknd 3255 10 , , , cord-010119-t1x9gknd 3255 11 Apheresis Apheresis NNP cord-010119-t1x9gknd 3255 12 products product NNS cord-010119-t1x9gknd 3255 13 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3255 14 using use VBG cord-010119-t1x9gknd 3255 15 the the DT cord-010119-t1x9gknd 3255 16 recommended recommend VBN cord-010119-t1x9gknd 3255 17 replacement replacement NN cord-010119-t1x9gknd 3255 18 ( ( -LRB- cord-010119-t1x9gknd 3255 19 Hetastarch Hetastarch NNP cord-010119-t1x9gknd 3255 20 ) ) -RRB- cord-010119-t1x9gknd 3255 21 . . . cord-010119-t1x9gknd 3256 1 Results/ Results/ . cord-010119-t1x9gknd 3257 1 Finding finding NN cord-010119-t1x9gknd 3257 2 : : : cord-010119-t1x9gknd 3258 1 Phase phase NN cord-010119-t1x9gknd 3259 1 I -PRON- PRP cord-010119-t1x9gknd 3260 1 -Results -Results NNP cord-010119-t1x9gknd 3260 2 indicate indicate VBP cord-010119-t1x9gknd 3260 3 that that IN cord-010119-t1x9gknd 3260 4 aliquots aliquot NNS cord-010119-t1x9gknd 3260 5 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3260 6 in in IN cord-010119-t1x9gknd 3260 7 5 5 CD cord-010119-t1x9gknd 3260 8 % % NN cord-010119-t1x9gknd 3260 9 DMSO DMSO NNP cord-010119-t1x9gknd 3260 10 and and CC cord-010119-t1x9gknd 3260 11 1.7 1.7 CD cord-010119-t1x9gknd 3260 12 % % NN cord-010119-t1x9gknd 3260 13 HES HES NNP cord-010119-t1x9gknd 3260 14 ( ( -LRB- cord-010119-t1x9gknd 3260 15 Hetastarch Hetastarch NNP cord-010119-t1x9gknd 3260 16 ) ) -RRB- cord-010119-t1x9gknd 3260 17 did do VBD cord-010119-t1x9gknd 3260 18 not not RB cord-010119-t1x9gknd 3260 19 behave behave VB cord-010119-t1x9gknd 3260 20 significantly significantly RB cord-010119-t1x9gknd 3260 21 different different JJ cord-010119-t1x9gknd 3260 22 than than IN cord-010119-t1x9gknd 3260 23 cells cell NNS cord-010119-t1x9gknd 3260 24 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3260 25 in in IN cord-010119-t1x9gknd 3260 26 the the DT cord-010119-t1x9gknd 3260 27 control control NN cord-010119-t1x9gknd 3260 28 in in IN cord-010119-t1x9gknd 3260 29 terms term NNS cord-010119-t1x9gknd 3260 30 of of IN cord-010119-t1x9gknd 3260 31 cell cell NN cord-010119-t1x9gknd 3260 32 recovery recovery NN cord-010119-t1x9gknd 3260 33 , , , cord-010119-t1x9gknd 3260 34 viability viability NN cord-010119-t1x9gknd 3260 35 or or CC cord-010119-t1x9gknd 3260 36 cell cell NN cord-010119-t1x9gknd 3260 37 proliferation proliferation NN cord-010119-t1x9gknd 3260 38 assay assay NN cord-010119-t1x9gknd 3260 39 ( ( -LRB- cord-010119-t1x9gknd 3260 40 CFU CFU NNP cord-010119-t1x9gknd 3260 41 ) ) -RRB- cord-010119-t1x9gknd 3260 42 . . . cord-010119-t1x9gknd 3261 1 Phase phase NN cord-010119-t1x9gknd 3261 2 II ii CD cord-010119-t1x9gknd 3262 1 -The -The : cord-010119-t1x9gknd 3262 2 majority majority NN cord-010119-t1x9gknd 3262 3 of of IN cord-010119-t1x9gknd 3262 4 freezing freeze VBG cord-010119-t1x9gknd 3262 5 profiles profile NNS cord-010119-t1x9gknd 3262 6 displayed display VBD cord-010119-t1x9gknd 3262 7 typical typical JJ cord-010119-t1x9gknd 3262 8 or or CC cord-010119-t1x9gknd 3262 9 expected expect VBN cord-010119-t1x9gknd 3262 10 bulk bulk JJ cord-010119-t1x9gknd 3262 11 freezing freezing NN cord-010119-t1x9gknd 3262 12 profiles profile NNS cord-010119-t1x9gknd 3262 13 for for IN cord-010119-t1x9gknd 3262 14 both both DT cord-010119-t1x9gknd 3262 15 formulations formulation NNS cord-010119-t1x9gknd 3262 16 . . . cord-010119-t1x9gknd 3263 1 Phase phase NN cord-010119-t1x9gknd 3263 2 III iii CD cord-010119-t1x9gknd 3263 3 -Transplants -transplant VBZ cord-010119-t1x9gknd 3263 4 performed perform VBN cord-010119-t1x9gknd 3263 5 resulted result VBD cord-010119-t1x9gknd 3263 6 in in IN cord-010119-t1x9gknd 3263 7 a a DT cord-010119-t1x9gknd 3263 8 mean mean JJ cord-010119-t1x9gknd 3263 9 engraftment engraftment NN cord-010119-t1x9gknd 3263 10 time time NN cord-010119-t1x9gknd 3263 11 of of IN cord-010119-t1x9gknd 3263 12 12.6 12.6 CD cord-010119-t1x9gknd 3263 13 days day NNS cord-010119-t1x9gknd 3263 14 for for IN cord-010119-t1x9gknd 3263 15 ANC500 ANC500 NNP cord-010119-t1x9gknd 3263 16 with with IN cord-010119-t1x9gknd 3263 17 no no DT cord-010119-t1x9gknd 3263 18 adverse adverse JJ cord-010119-t1x9gknd 3263 19 patient patient JJ cord-010119-t1x9gknd 3263 20 reactions reaction NNS cord-010119-t1x9gknd 3263 21 observed observe VBN cord-010119-t1x9gknd 3263 22 . . . cord-010119-t1x9gknd 3264 1 Engraftment Engraftment NNP cord-010119-t1x9gknd 3264 2 times time NNS cord-010119-t1x9gknd 3264 3 using use VBG cord-010119-t1x9gknd 3264 4 the the DT cord-010119-t1x9gknd 3264 5 new new JJ cord-010119-t1x9gknd 3264 6 Hetastarch Hetastarch NNP cord-010119-t1x9gknd 3264 7 formula formula NN cord-010119-t1x9gknd 3264 8 were be VBD cord-010119-t1x9gknd 3264 9 compared compare VBN cord-010119-t1x9gknd 3264 10 to to IN cord-010119-t1x9gknd 3264 11 the the DT cord-010119-t1x9gknd 3264 12 previous previous JJ cord-010119-t1x9gknd 3264 13 engraftment engraftment NN cord-010119-t1x9gknd 3264 14 times time NNS cord-010119-t1x9gknd 3264 15 with with IN cord-010119-t1x9gknd 3264 16 no no DT cord-010119-t1x9gknd 3264 17 significant significant JJ cord-010119-t1x9gknd 3264 18 difference difference NN cord-010119-t1x9gknd 3264 19 . . . cord-010119-t1x9gknd 3265 1 Conclusion conclusion NN cord-010119-t1x9gknd 3265 2 : : : cord-010119-t1x9gknd 3266 1 A a DT cord-010119-t1x9gknd 3266 2 change change NN cord-010119-t1x9gknd 3266 3 in in IN cord-010119-t1x9gknd 3266 4 the the DT cord-010119-t1x9gknd 3266 5 formulation formulation NN cord-010119-t1x9gknd 3266 6 of of IN cord-010119-t1x9gknd 3266 7 a a DT cord-010119-t1x9gknd 3266 8 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3266 9 solution solution NN cord-010119-t1x9gknd 3266 10 represents represent VBZ cord-010119-t1x9gknd 3266 11 a a DT cord-010119-t1x9gknd 3266 12 major major JJ cord-010119-t1x9gknd 3266 13 change change NN cord-010119-t1x9gknd 3266 14 that that WDT cord-010119-t1x9gknd 3266 15 could could MD cord-010119-t1x9gknd 3266 16 have have VB cord-010119-t1x9gknd 3266 17 a a DT cord-010119-t1x9gknd 3266 18 significant significant JJ cord-010119-t1x9gknd 3266 19 impact impact NN cord-010119-t1x9gknd 3266 20 on on IN cord-010119-t1x9gknd 3266 21 quality quality NN cord-010119-t1x9gknd 3266 22 . . . cord-010119-t1x9gknd 3267 1 In in IN cord-010119-t1x9gknd 3267 2 addition addition NN cord-010119-t1x9gknd 3267 3 , , , cord-010119-t1x9gknd 3267 4 maintaining maintain VBG cord-010119-t1x9gknd 3267 5 the the DT cord-010119-t1x9gknd 3267 6 current current JJ cord-010119-t1x9gknd 3267 7 5 5 CD cord-010119-t1x9gknd 3267 8 % % NN cord-010119-t1x9gknd 3267 9 DMSO DMSO NNP cord-010119-t1x9gknd 3267 10 final final JJ cord-010119-t1x9gknd 3267 11 concentration concentration NN cord-010119-t1x9gknd 3267 12 was be VBD cord-010119-t1x9gknd 3267 13 critical critical JJ cord-010119-t1x9gknd 3267 14 as as IN cord-010119-t1x9gknd 3267 15 post post NN cord-010119-t1x9gknd 3267 16 thaw thaw NN cord-010119-t1x9gknd 3267 17 washing washing NN cord-010119-t1x9gknd 3267 18 is be VBZ cord-010119-t1x9gknd 3267 19 not not RB cord-010119-t1x9gknd 3267 20 performed perform VBN cord-010119-t1x9gknd 3267 21 at at IN cord-010119-t1x9gknd 3267 22 the the DT cord-010119-t1x9gknd 3267 23 clinical clinical JJ cord-010119-t1x9gknd 3267 24 site site NN cord-010119-t1x9gknd 3267 25 , , , cord-010119-t1x9gknd 3267 26 history history NN cord-010119-t1x9gknd 3267 27 demonstrating demonstrate VBG cord-010119-t1x9gknd 3267 28 a a DT cord-010119-t1x9gknd 3267 29 very very RB cord-010119-t1x9gknd 3267 30 low low JJ cord-010119-t1x9gknd 3267 31 toxicity toxicity NN cord-010119-t1x9gknd 3267 32 rate rate NN cord-010119-t1x9gknd 3267 33 with with IN cord-010119-t1x9gknd 3267 34 the the DT cord-010119-t1x9gknd 3267 35 existing exist VBG cord-010119-t1x9gknd 3267 36 formulation formulation NN cord-010119-t1x9gknd 3267 37 . . . cord-010119-t1x9gknd 3268 1 This this DT cord-010119-t1x9gknd 3268 2 study study NN cord-010119-t1x9gknd 3268 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 3268 4 the the DT cord-010119-t1x9gknd 3268 5 acceptability acceptability NN cord-010119-t1x9gknd 3268 6 of of IN cord-010119-t1x9gknd 3268 7 the the DT cord-010119-t1x9gknd 3268 8 Hetastarch Hetastarch NNP cord-010119-t1x9gknd 3268 9 formulation formulation NN cord-010119-t1x9gknd 3268 10 using use VBG cord-010119-t1x9gknd 3268 11 5 5 CD cord-010119-t1x9gknd 3268 12 % % NN cord-010119-t1x9gknd 3268 13 DMSO DMSO NNP cord-010119-t1x9gknd 3268 14 and and CC cord-010119-t1x9gknd 3268 15 1.7 1.7 CD cord-010119-t1x9gknd 3268 16 % % NN cord-010119-t1x9gknd 3268 17 Hetastarch Hetastarch NNP cord-010119-t1x9gknd 3268 18 to to TO cord-010119-t1x9gknd 3268 19 replace replace VB cord-010119-t1x9gknd 3268 20 Pentastarch Pentastarch NNP cord-010119-t1x9gknd 3268 21 in in IN cord-010119-t1x9gknd 3268 22 the the DT cord-010119-t1x9gknd 3268 23 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3268 24 formulation formulation NN cord-010119-t1x9gknd 3268 25 used use VBN cord-010119-t1x9gknd 3268 26 for for IN cord-010119-t1x9gknd 3268 27 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3268 28 of of IN cord-010119-t1x9gknd 3268 29 HPC HPC NNP cord-010119-t1x9gknd 3268 30 , , , cord-010119-t1x9gknd 3268 31 Apheresis Apheresis NNP cord-010119-t1x9gknd 3268 32 products product NNS cord-010119-t1x9gknd 3268 33 . . . cord-010119-t1x9gknd 3269 1 Background Background NNP cord-010119-t1x9gknd 3269 2 / / SYM cord-010119-t1x9gknd 3269 3 Case Case NNP cord-010119-t1x9gknd 3269 4 Studies Studies NNPS cord-010119-t1x9gknd 3269 5 : : : cord-010119-t1x9gknd 3269 6 Autologous autologous JJ cord-010119-t1x9gknd 3269 7 stem stem NN cord-010119-t1x9gknd 3269 8 cell cell NN cord-010119-t1x9gknd 3269 9 transplantation transplantation NN cord-010119-t1x9gknd 3269 10 is be VBZ cord-010119-t1x9gknd 3269 11 usually usually RB cord-010119-t1x9gknd 3269 12 performed perform VBN cord-010119-t1x9gknd 3269 13 with with IN cord-010119-t1x9gknd 3269 14 mobilized mobilize VBN cord-010119-t1x9gknd 3269 15 peripheral peripheral JJ cord-010119-t1x9gknd 3269 16 blood blood NN cord-010119-t1x9gknd 3269 17 stem stem NN cord-010119-t1x9gknd 3269 18 cells cell NNS cord-010119-t1x9gknd 3269 19 ( ( -LRB- cord-010119-t1x9gknd 3269 20 PBSCs pbsc NNS cord-010119-t1x9gknd 3269 21 ) ) -RRB- cord-010119-t1x9gknd 3269 22 . . . cord-010119-t1x9gknd 3270 1 Traditional traditional JJ cord-010119-t1x9gknd 3270 2 mobilization mobilization NN cord-010119-t1x9gknd 3270 3 regimens regimen NNS cord-010119-t1x9gknd 3270 4 include include VBP cord-010119-t1x9gknd 3270 5 granulocyte granulocyte NN cord-010119-t1x9gknd 3270 6 colony colony NN cord-010119-t1x9gknd 3270 7 stimulating stimulate VBG cord-010119-t1x9gknd 3270 8 factor factor NN cord-010119-t1x9gknd 3270 9 ( ( -LRB- cord-010119-t1x9gknd 3270 10 G G NNP cord-010119-t1x9gknd 3270 11 - - HYPH cord-010119-t1x9gknd 3270 12 CSF CSF NNP cord-010119-t1x9gknd 3270 13 ) ) -RRB- cord-010119-t1x9gknd 3270 14 with with IN cord-010119-t1x9gknd 3270 15 or or CC cord-010119-t1x9gknd 3270 16 without without IN cord-010119-t1x9gknd 3270 17 chemotherapy chemotherapy NN cord-010119-t1x9gknd 3270 18 , , , cord-010119-t1x9gknd 3270 19 but but CC cord-010119-t1x9gknd 3270 20 have have VBP cord-010119-t1x9gknd 3270 21 failure failure NN cord-010119-t1x9gknd 3270 22 rates rate NNS cord-010119-t1x9gknd 3270 23 ranging range VBG cord-010119-t1x9gknd 3270 24 from from IN cord-010119-t1x9gknd 3270 25 5 5 CD cord-010119-t1x9gknd 3270 26 % % NN cord-010119-t1x9gknd 3270 27 to to IN cord-010119-t1x9gknd 3270 28 40 40 CD cord-010119-t1x9gknd 3270 29 % % NN cord-010119-t1x9gknd 3270 30 . . . cord-010119-t1x9gknd 3271 1 Plerixafor Plerixafor NNP cord-010119-t1x9gknd 3271 2 is be VBZ cord-010119-t1x9gknd 3271 3 an an DT cord-010119-t1x9gknd 3271 4 adjunct adjunct JJ cord-010119-t1x9gknd 3271 5 agent agent NN cord-010119-t1x9gknd 3271 6 used use VBD cord-010119-t1x9gknd 3271 7 to to TO cord-010119-t1x9gknd 3271 8 improve improve VB cord-010119-t1x9gknd 3271 9 mobilization mobilization NN cord-010119-t1x9gknd 3271 10 in in IN cord-010119-t1x9gknd 3271 11 many many JJ cord-010119-t1x9gknd 3271 12 clinical clinical JJ cord-010119-t1x9gknd 3271 13 settings setting NNS cord-010119-t1x9gknd 3271 14 . . . cord-010119-t1x9gknd 3272 1 However however RB cord-010119-t1x9gknd 3272 2 , , , cord-010119-t1x9gknd 3272 3 its -PRON- PRP$ cord-010119-t1x9gknd 3272 4 high high JJ cord-010119-t1x9gknd 3272 5 cost cost NN cord-010119-t1x9gknd 3272 6 is be VBZ cord-010119-t1x9gknd 3272 7 a a DT cord-010119-t1x9gknd 3272 8 significant significant JJ cord-010119-t1x9gknd 3272 9 concern concern NN cord-010119-t1x9gknd 3272 10 . . . cord-010119-t1x9gknd 3273 1 The the DT cord-010119-t1x9gknd 3273 2 manufacturer manufacturer NN cord-010119-t1x9gknd 3273 3 - - HYPH cord-010119-t1x9gknd 3273 4 recommended recommend VBN cord-010119-t1x9gknd 3273 5 dose dose NN cord-010119-t1x9gknd 3273 6 is be VBZ cord-010119-t1x9gknd 3273 7 0.24 0.24 CD cord-010119-t1x9gknd 3273 8 mg mg NNP cord-010119-t1x9gknd 3273 9 / / SYM cord-010119-t1x9gknd 3273 10 kg kg NNS cord-010119-t1x9gknd 3273 11 , , , cord-010119-t1x9gknd 3273 12 therefore therefore RB cord-010119-t1x9gknd 3273 13 patients patient NNS cord-010119-t1x9gknd 3273 14 weighing weigh VBG cord-010119-t1x9gknd 3273 15 > > XX cord-010119-t1x9gknd 3273 16 100 100 CD cord-010119-t1x9gknd 3273 17 kg kg NNS cord-010119-t1x9gknd 3273 18 would would MD cord-010119-t1x9gknd 3273 19 require require VB cord-010119-t1x9gknd 3273 20 a a DT cord-010119-t1x9gknd 3273 21 second second JJ cord-010119-t1x9gknd 3273 22 vial vial NN cord-010119-t1x9gknd 3273 23 , , , cord-010119-t1x9gknd 3273 24 thus thus RB cord-010119-t1x9gknd 3273 25 doubling double VBG cord-010119-t1x9gknd 3273 26 the the DT cord-010119-t1x9gknd 3273 27 drug drug NN cord-010119-t1x9gknd 3273 28 cost cost NN cord-010119-t1x9gknd 3273 29 . . . cord-010119-t1x9gknd 3274 1 In in IN cord-010119-t1x9gknd 3274 2 2013 2013 CD cord-010119-t1x9gknd 3274 3 we -PRON- PRP cord-010119-t1x9gknd 3274 4 implemented implement VBD cord-010119-t1x9gknd 3274 5 a a DT cord-010119-t1x9gknd 3274 6 policy policy NN cord-010119-t1x9gknd 3274 7 of of IN cord-010119-t1x9gknd 3274 8 capping cap VBG cord-010119-t1x9gknd 3274 9 plerixafor plerixafor NN cord-010119-t1x9gknd 3274 10 at at IN cord-010119-t1x9gknd 3274 11 24 24 CD cord-010119-t1x9gknd 3274 12 mg mg NN cord-010119-t1x9gknd 3274 13 for for IN cord-010119-t1x9gknd 3274 14 patients patient NNS cord-010119-t1x9gknd 3274 15 weighing weigh VBG cord-010119-t1x9gknd 3274 16 > > XX cord-010119-t1x9gknd 3274 17 100 100 CD cord-010119-t1x9gknd 3274 18 kg kg NNS cord-010119-t1x9gknd 3274 19 . . . cord-010119-t1x9gknd 3275 1 This this DT cord-010119-t1x9gknd 3275 2 retrospective retrospective JJ cord-010119-t1x9gknd 3275 3 study study NN cord-010119-t1x9gknd 3275 4 compares compare VBZ cord-010119-t1x9gknd 3275 5 the the DT cord-010119-t1x9gknd 3275 6 mobilization mobilization NN cord-010119-t1x9gknd 3275 7 of of IN cord-010119-t1x9gknd 3275 8 patients patient NNS cord-010119-t1x9gknd 3275 9 > > XX cord-010119-t1x9gknd 3275 10 100 100 CD cord-010119-t1x9gknd 3275 11 kg kg NNS cord-010119-t1x9gknd 3275 12 who who WP cord-010119-t1x9gknd 3275 13 received receive VBD cord-010119-t1x9gknd 3275 14 capped cap VBN cord-010119-t1x9gknd 3275 15 doses dose NNS cord-010119-t1x9gknd 3275 16 ( ( -LRB- cord-010119-t1x9gknd 3275 17 2013 2013 CD cord-010119-t1x9gknd 3275 18 ) ) -RRB- cord-010119-t1x9gknd 3275 19 ( ( -LRB- cord-010119-t1x9gknd 3275 20 2014 2014 CD cord-010119-t1x9gknd 3275 21 ) ) -RRB- cord-010119-t1x9gknd 3275 22 ( ( -LRB- cord-010119-t1x9gknd 3275 23 2015 2015 CD cord-010119-t1x9gknd 3275 24 ) ) -RRB- cord-010119-t1x9gknd 3275 25 ( ( -LRB- cord-010119-t1x9gknd 3275 26 2016 2016 CD cord-010119-t1x9gknd 3275 27 ) ) -RRB- cord-010119-t1x9gknd 3275 28 , , , cord-010119-t1x9gknd 3275 29 with with IN cord-010119-t1x9gknd 3275 30 historical historical JJ cord-010119-t1x9gknd 3275 31 control control NN cord-010119-t1x9gknd 3275 32 patients patient NNS cord-010119-t1x9gknd 3275 33 ( ( -LRB- cord-010119-t1x9gknd 3275 34 2010 2010 CD cord-010119-t1x9gknd 3275 35 - - SYM cord-010119-t1x9gknd 3275 36 2013 2013 CD cord-010119-t1x9gknd 3275 37 ) ) -RRB- cord-010119-t1x9gknd 3275 38 who who WP cord-010119-t1x9gknd 3275 39 received receive VBD cord-010119-t1x9gknd 3275 40 full full JJ cord-010119-t1x9gknd 3275 41 or or CC cord-010119-t1x9gknd 3275 42 uncapped uncapped JJ cord-010119-t1x9gknd 3275 43 doses dose NNS cord-010119-t1x9gknd 3275 44 . . . cord-010119-t1x9gknd 3276 1 Study Study NNP cord-010119-t1x9gknd 3276 2 Design Design NNP cord-010119-t1x9gknd 3276 3 / / SYM cord-010119-t1x9gknd 3276 4 Method method NN cord-010119-t1x9gknd 3276 5 : : : cord-010119-t1x9gknd 3276 6 Patients patient NNS cord-010119-t1x9gknd 3276 7 weighing weigh VBG cord-010119-t1x9gknd 3276 8 > > XX cord-010119-t1x9gknd 3276 9 100 100 CD cord-010119-t1x9gknd 3276 10 kg kg NNS cord-010119-t1x9gknd 3276 11 with with IN cord-010119-t1x9gknd 3276 12 CrCL CrCL NNP cord-010119-t1x9gknd 3277 1 > > XX cord-010119-t1x9gknd 3278 1 50ml 50ml NNP cord-010119-t1x9gknd 3278 2 / / SYM cord-010119-t1x9gknd 3278 3 min min NNP cord-010119-t1x9gknd 3278 4 who who WP cord-010119-t1x9gknd 3278 5 received receive VBD cord-010119-t1x9gknd 3278 6 capped capped JJ cord-010119-t1x9gknd 3278 7 and and CC cord-010119-t1x9gknd 3278 8 full full JJ cord-010119-t1x9gknd 3278 9 doses dose NNS cord-010119-t1x9gknd 3278 10 of of IN cord-010119-t1x9gknd 3278 11 plerixafor plerixafor NN cord-010119-t1x9gknd 3278 12 were be VBD cord-010119-t1x9gknd 3278 13 identified identify VBN cord-010119-t1x9gknd 3278 14 in in IN cord-010119-t1x9gknd 3278 15 the the DT cord-010119-t1x9gknd 3278 16 pharmacy pharmacy NN cord-010119-t1x9gknd 3278 17 database database NN cord-010119-t1x9gknd 3278 18 . . . cord-010119-t1x9gknd 3279 1 Electronic electronic JJ cord-010119-t1x9gknd 3279 2 medical medical JJ cord-010119-t1x9gknd 3279 3 records record NNS cord-010119-t1x9gknd 3279 4 were be VBD cord-010119-t1x9gknd 3279 5 used use VBN cord-010119-t1x9gknd 3279 6 to to TO cord-010119-t1x9gknd 3279 7 collect collect VB cord-010119-t1x9gknd 3279 8 baseline baseline JJ cord-010119-t1x9gknd 3279 9 characteristics characteristic NNS cord-010119-t1x9gknd 3279 10 and and CC cord-010119-t1x9gknd 3279 11 cell cell NN cord-010119-t1x9gknd 3279 12 collection collection NN cord-010119-t1x9gknd 3279 13 data datum NNS cord-010119-t1x9gknd 3279 14 . . . cord-010119-t1x9gknd 3280 1 Results result NNS cord-010119-t1x9gknd 3280 2 / / SYM cord-010119-t1x9gknd 3280 3 Findings finding NNS cord-010119-t1x9gknd 3280 4 : : : cord-010119-t1x9gknd 3281 1 A a DT cord-010119-t1x9gknd 3281 2 total total NN cord-010119-t1x9gknd 3281 3 of of IN cord-010119-t1x9gknd 3281 4 47 47 CD cord-010119-t1x9gknd 3281 5 and and CC cord-010119-t1x9gknd 3281 6 40 40 CD cord-010119-t1x9gknd 3281 7 consecutive consecutive JJ cord-010119-t1x9gknd 3281 8 patients patient NNS cord-010119-t1x9gknd 3281 9 were be VBD cord-010119-t1x9gknd 3281 10 included include VBN cord-010119-t1x9gknd 3281 11 in in IN cord-010119-t1x9gknd 3281 12 the the DT cord-010119-t1x9gknd 3281 13 capped capped JJ cord-010119-t1x9gknd 3281 14 and and CC cord-010119-t1x9gknd 3281 15 full full JJ cord-010119-t1x9gknd 3281 16 dosing dosing NN cord-010119-t1x9gknd 3281 17 groups group NNS cord-010119-t1x9gknd 3281 18 , , , cord-010119-t1x9gknd 3281 19 respectively respectively RB cord-010119-t1x9gknd 3281 20 . . . cord-010119-t1x9gknd 3282 1 They -PRON- PRP cord-010119-t1x9gknd 3282 2 showed show VBD cord-010119-t1x9gknd 3282 3 comparable comparable JJ cord-010119-t1x9gknd 3282 4 baseline baseline JJ cord-010119-t1x9gknd 3282 5 distributions distribution NNS cord-010119-t1x9gknd 3282 6 of of IN cord-010119-t1x9gknd 3282 7 age age NN cord-010119-t1x9gknd 3282 8 , , , cord-010119-t1x9gknd 3282 9 weight weight NN cord-010119-t1x9gknd 3282 10 , , , cord-010119-t1x9gknd 3282 11 gender gender NN cord-010119-t1x9gknd 3282 12 and and CC cord-010119-t1x9gknd 3282 13 diagnoses diagnosis NNS cord-010119-t1x9gknd 3282 14 . . . cord-010119-t1x9gknd 3283 1 Plerixafor Plerixafor NNP cord-010119-t1x9gknd 3283 2 was be VBD cord-010119-t1x9gknd 3283 3 given give VBN cord-010119-t1x9gknd 3283 4 upfront upfront NN cord-010119-t1x9gknd 3283 5 , , , cord-010119-t1x9gknd 3283 6 or or CC cord-010119-t1x9gknd 3283 7 as as IN cord-010119-t1x9gknd 3283 8 a a DT cord-010119-t1x9gknd 3283 9 rescue rescue NN cord-010119-t1x9gknd 3283 10 agent agent NN cord-010119-t1x9gknd 3283 11 due due IN cord-010119-t1x9gknd 3283 12 to to IN cord-010119-t1x9gknd 3283 13 suboptimal suboptimal JJ cord-010119-t1x9gknd 3283 14 mobilization mobilization NN cord-010119-t1x9gknd 3283 15 in in IN cord-010119-t1x9gknd 3283 16 both both DT cord-010119-t1x9gknd 3283 17 groups group NNS cord-010119-t1x9gknd 3283 18 . . . cord-010119-t1x9gknd 3284 1 In in IN cord-010119-t1x9gknd 3284 2 the the DT cord-010119-t1x9gknd 3284 3 capped cap VBN cord-010119-t1x9gknd 3284 4 dosing dosing NN cord-010119-t1x9gknd 3284 5 group group NN cord-010119-t1x9gknd 3284 6 , , , cord-010119-t1x9gknd 3284 7 fewer few JJR cord-010119-t1x9gknd 3284 8 patients patient NNS cord-010119-t1x9gknd 3284 9 received receive VBD cord-010119-t1x9gknd 3284 10 chemomobilization chemomobilization NN cord-010119-t1x9gknd 3284 11 or or CC cord-010119-t1x9gknd 3284 12 plerixafor plerixafor NN cord-010119-t1x9gknd 3284 13 upfront upfront JJ cord-010119-t1x9gknd 3284 14 . . . cord-010119-t1x9gknd 3285 1 When when WRB cord-010119-t1x9gknd 3285 2 compared compare VBN cord-010119-t1x9gknd 3285 3 to to IN cord-010119-t1x9gknd 3285 4 historical historical JJ cord-010119-t1x9gknd 3285 5 controls control NNS cord-010119-t1x9gknd 3285 6 , , , cord-010119-t1x9gknd 3285 7 they -PRON- PRP cord-010119-t1x9gknd 3285 8 used use VBD cord-010119-t1x9gknd 3285 9 half half NN cord-010119-t1x9gknd 3285 10 of of IN cord-010119-t1x9gknd 3285 11 the the DT cord-010119-t1x9gknd 3285 12 number number NN cord-010119-t1x9gknd 3285 13 of of IN cord-010119-t1x9gknd 3285 14 vials vial NNS cord-010119-t1x9gknd 3285 15 of of IN cord-010119-t1x9gknd 3285 16 plerixafor plerixafor NN cord-010119-t1x9gknd 3285 17 , , , cord-010119-t1x9gknd 3285 18 but but CC cord-010119-t1x9gknd 3285 19 collected collect VBD cord-010119-t1x9gknd 3285 20 similar similar JJ cord-010119-t1x9gknd 3285 21 numbers number NNS cord-010119-t1x9gknd 3285 22 of of IN cord-010119-t1x9gknd 3285 23 CD341 cd341 NN cord-010119-t1x9gknd 3285 24 / / SYM cord-010119-t1x9gknd 3285 25 cells cell NNS cord-010119-t1x9gknd 3285 26 kg kg NNS cord-010119-t1x9gknd 3285 27 and and CC cord-010119-t1x9gknd 3285 28 achieved achieve VBD cord-010119-t1x9gknd 3285 29 a a DT cord-010119-t1x9gknd 3285 30 comparable comparable JJ cord-010119-t1x9gknd 3285 31 collection collection NN cord-010119-t1x9gknd 3285 32 success success NN cord-010119-t1x9gknd 3285 33 rate rate NN cord-010119-t1x9gknd 3285 34 . . . cord-010119-t1x9gknd 3286 1 The the DT cord-010119-t1x9gknd 3286 2 strategy strategy NN cord-010119-t1x9gknd 3286 3 dose dose NN cord-010119-t1x9gknd 3286 4 capping cap VBG cord-010119-t1x9gknd 3286 5 plerixafor plerixafor NN cord-010119-t1x9gknd 3286 6 at at IN cord-010119-t1x9gknd 3286 7 24 24 CD cord-010119-t1x9gknd 3286 8 mg mg NN cord-010119-t1x9gknd 3286 9 for for IN cord-010119-t1x9gknd 3286 10 patients patient NNS cord-010119-t1x9gknd 3286 11 > > XX cord-010119-t1x9gknd 3287 1 100 100 CD cord-010119-t1x9gknd 3287 2 kg kg NN cord-010119-t1x9gknd 3287 3 is be VBZ cord-010119-t1x9gknd 3287 4 cost cost NN cord-010119-t1x9gknd 3287 5 - - HYPH cord-010119-t1x9gknd 3287 6 effective effective JJ cord-010119-t1x9gknd 3287 7 and and CC cord-010119-t1x9gknd 3287 8 achieves achieve VBZ cord-010119-t1x9gknd 3287 9 comparable comparable JJ cord-010119-t1x9gknd 3287 10 mobilization mobilization NN cord-010119-t1x9gknd 3287 11 outcomes outcome NNS cord-010119-t1x9gknd 3287 12 while while IN cord-010119-t1x9gknd 3287 13 decreasing decrease VBG cord-010119-t1x9gknd 3287 14 the the DT cord-010119-t1x9gknd 3287 15 drug drug NN cord-010119-t1x9gknd 3287 16 cost cost NN cord-010119-t1x9gknd 3287 17 by by IN cord-010119-t1x9gknd 3287 18 half half NN cord-010119-t1x9gknd 3287 19 . . . cord-010119-t1x9gknd 3288 1 Mean mean JJ cord-010119-t1x9gknd 3288 2 and and CC cord-010119-t1x9gknd 3288 3 range range NN cord-010119-t1x9gknd 3288 4 of of IN cord-010119-t1x9gknd 3288 5 % % NN cord-010119-t1x9gknd 3288 6 CD34 CD34 NNP cord-010119-t1x9gknd 3288 7 in in IN cord-010119-t1x9gknd 3288 8 peripheral peripheral JJ cord-010119-t1x9gknd 3288 9 blood blood NN cord-010119-t1x9gknd 3288 10 were be VBD cord-010119-t1x9gknd 3288 11 calculated calculate VBN cord-010119-t1x9gknd 3288 12 . . . cord-010119-t1x9gknd 3289 1 The the DT cord-010119-t1x9gknd 3289 2 data datum NNS cord-010119-t1x9gknd 3289 3 show show VBP cord-010119-t1x9gknd 3289 4 that that IN cord-010119-t1x9gknd 3289 5 in in IN cord-010119-t1x9gknd 3289 6 the the DT cord-010119-t1x9gknd 3289 7 Non non JJ cord-010119-t1x9gknd 3289 8 - - JJ cord-010119-t1x9gknd 3289 9 Hispanic hispanic JJ cord-010119-t1x9gknd 3289 10 group group NN cord-010119-t1x9gknd 3289 11 , , , cord-010119-t1x9gknd 3289 12 the the DT cord-010119-t1x9gknd 3289 13 youngest young JJS cord-010119-t1x9gknd 3289 14 donors donor NNS cord-010119-t1x9gknd 3289 15 ( ( -LRB- cord-010119-t1x9gknd 3289 16 < < NNP cord-010119-t1x9gknd 3289 17 30yrs 30yrs NNP cord-010119-t1x9gknd 3289 18 ) ) -RRB- cord-010119-t1x9gknd 3289 19 have have VBP cord-010119-t1x9gknd 3289 20 a a DT cord-010119-t1x9gknd 3289 21 higher high JJR cord-010119-t1x9gknd 3289 22 pre pre JJ cord-010119-t1x9gknd 3289 23 - - JJ cord-010119-t1x9gknd 3289 24 apheresis apheresis JJ cord-010119-t1x9gknd 3289 25 % % NN cord-010119-t1x9gknd 3289 26 CD34 CD34 NNP cord-010119-t1x9gknd 3289 27 level level NN cord-010119-t1x9gknd 3289 28 than than IN cord-010119-t1x9gknd 3289 29 any any DT cord-010119-t1x9gknd 3289 30 of of IN cord-010119-t1x9gknd 3289 31 the the DT cord-010119-t1x9gknd 3289 32 other other JJ cord-010119-t1x9gknd 3289 33 groups group NNS cord-010119-t1x9gknd 3289 34 , , , cord-010119-t1x9gknd 3289 35 reaching reach VBG cord-010119-t1x9gknd 3289 36 statistical statistical JJ cord-010119-t1x9gknd 3289 37 significance significance NN cord-010119-t1x9gknd 3289 38 when when WRB cord-010119-t1x9gknd 3289 39 comparing compare VBG cord-010119-t1x9gknd 3289 40 the the DT cord-010119-t1x9gknd 3289 41 % % NN cord-010119-t1x9gknd 3289 42 CD34 CD34 NNP cord-010119-t1x9gknd 3289 43 pre pre JJ cord-010119-t1x9gknd 3289 44 - - NN cord-010119-t1x9gknd 3289 45 apheresis apheresis NN cord-010119-t1x9gknd 3289 46 between between IN cord-010119-t1x9gknd 3289 47 the the DT cord-010119-t1x9gknd 3289 48 youngest young JJS cord-010119-t1x9gknd 3289 49 group group NN cord-010119-t1x9gknd 3289 50 ( ( -LRB- cord-010119-t1x9gknd 3289 51 < < NNP cord-010119-t1x9gknd 3289 52 30 30 CD cord-010119-t1x9gknd 3289 53 yrs yrs NNP cord-010119-t1x9gknd 3289 54 ) ) -RRB- cord-010119-t1x9gknd 3289 55 and and CC cord-010119-t1x9gknd 3289 56 the the DT cord-010119-t1x9gknd 3289 57 oldest old JJS cord-010119-t1x9gknd 3289 58 group group NN cord-010119-t1x9gknd 3289 59 ( ( -LRB- cord-010119-t1x9gknd 3289 60 > > NFP cord-010119-t1x9gknd 3289 61 540 540 CD cord-010119-t1x9gknd 3289 62 yrs yr NNS cord-010119-t1x9gknd 3289 63 ) ) -RRB- cord-010119-t1x9gknd 3289 64 . . . cord-010119-t1x9gknd 3290 1 Hispanic hispanic JJ cord-010119-t1x9gknd 3290 2 donors donor NNS cord-010119-t1x9gknd 3290 3 show show VBP cord-010119-t1x9gknd 3290 4 statistically statistically RB cord-010119-t1x9gknd 3290 5 similar similar JJ cord-010119-t1x9gknd 3290 6 % % NN cord-010119-t1x9gknd 3290 7 CD34 CD34 NNP cord-010119-t1x9gknd 3290 8 pre pre JJ cord-010119-t1x9gknd 3290 9 - - JJ cord-010119-t1x9gknd 3290 10 apheresis apheresis JJ cord-010119-t1x9gknd 3290 11 levels level NNS cord-010119-t1x9gknd 3290 12 over over IN cord-010119-t1x9gknd 3290 13 all all DT cord-010119-t1x9gknd 3290 14 age age NN cord-010119-t1x9gknd 3290 15 groups group NNS cord-010119-t1x9gknd 3290 16 . . . cord-010119-t1x9gknd 3291 1 Moreover moreover RB cord-010119-t1x9gknd 3291 2 , , , cord-010119-t1x9gknd 3291 3 the the DT cord-010119-t1x9gknd 3291 4 Hispanic hispanic JJ cord-010119-t1x9gknd 3291 5 older old JJR cord-010119-t1x9gknd 3291 6 age age NN cord-010119-t1x9gknd 3291 7 group group NN cord-010119-t1x9gknd 3291 8 ( ( -LRB- cord-010119-t1x9gknd 3291 9 > > NFP cord-010119-t1x9gknd 3291 10 540yrs 540yrs NNP cord-010119-t1x9gknd 3291 11 ) ) -RRB- cord-010119-t1x9gknd 3291 12 had have VBD cord-010119-t1x9gknd 3291 13 a a DT cord-010119-t1x9gknd 3291 14 statistically statistically RB cord-010119-t1x9gknd 3291 15 higher high JJR cord-010119-t1x9gknd 3291 16 % % NN cord-010119-t1x9gknd 3291 17 CD34 CD34 NNP cord-010119-t1x9gknd 3291 18 pre pre JJ cord-010119-t1x9gknd 3291 19 - - JJ cord-010119-t1x9gknd 3291 20 apheresis apheresis JJ cord-010119-t1x9gknd 3291 21 level level NN cord-010119-t1x9gknd 3291 22 than than IN cord-010119-t1x9gknd 3291 23 the the DT cord-010119-t1x9gknd 3291 24 Non non JJ cord-010119-t1x9gknd 3291 25 - - JJ cord-010119-t1x9gknd 3291 26 Hispanic hispanic JJ cord-010119-t1x9gknd 3291 27 older old JJR cord-010119-t1x9gknd 3291 28 age age NN cord-010119-t1x9gknd 3291 29 group group NN cord-010119-t1x9gknd 3291 30 . . . cord-010119-t1x9gknd 3292 1 Conclusion conclusion NN cord-010119-t1x9gknd 3292 2 : : : cord-010119-t1x9gknd 3293 1 In in IN cord-010119-t1x9gknd 3293 2 this this DT cord-010119-t1x9gknd 3293 3 analysis analysis NN cord-010119-t1x9gknd 3293 4 of of IN cord-010119-t1x9gknd 3293 5 121 121 CD cord-010119-t1x9gknd 3293 6 sequential sequential JJ cord-010119-t1x9gknd 3293 7 unrelated unrelated JJ cord-010119-t1x9gknd 3293 8 PBSC PBSC NNP cord-010119-t1x9gknd 3293 9 donors donor NNS cord-010119-t1x9gknd 3293 10 , , , cord-010119-t1x9gknd 3293 11 Hispanic hispanic JJ cord-010119-t1x9gknd 3293 12 donors donor NNS cord-010119-t1x9gknd 3293 13 maintain maintain VBP cord-010119-t1x9gknd 3293 14 a a DT cord-010119-t1x9gknd 3293 15 similar similar JJ cord-010119-t1x9gknd 3293 16 pre pre JJ cord-010119-t1x9gknd 3293 17 - - JJ cord-010119-t1x9gknd 3293 18 apheresis apheresis JJ cord-010119-t1x9gknd 3293 19 % % NN cord-010119-t1x9gknd 3293 20 CD34 CD34 NNP cord-010119-t1x9gknd 3293 21 level level NN cord-010119-t1x9gknd 3293 22 even even RB cord-010119-t1x9gknd 3293 23 as as IN cord-010119-t1x9gknd 3293 24 the the DT cord-010119-t1x9gknd 3293 25 donor donor NN cord-010119-t1x9gknd 3293 26 ages age NNS cord-010119-t1x9gknd 3293 27 , , , cord-010119-t1x9gknd 3293 28 while while IN cord-010119-t1x9gknd 3293 29 Non non JJ cord-010119-t1x9gknd 3293 30 - - JJ cord-010119-t1x9gknd 3293 31 Hispanic hispanic JJ cord-010119-t1x9gknd 3293 32 donors donor NNS cord-010119-t1x9gknd 3293 33 show show VBP cord-010119-t1x9gknd 3293 34 a a DT cord-010119-t1x9gknd 3293 35 decreasing decrease VBG cord-010119-t1x9gknd 3293 36 pre pre JJ cord-010119-t1x9gknd 3293 37 - - JJ cord-010119-t1x9gknd 3293 38 apheresis apheresis JJ cord-010119-t1x9gknd 3293 39 % % NN cord-010119-t1x9gknd 3293 40 CD34 CD34 NNP cord-010119-t1x9gknd 3293 41 level level NN cord-010119-t1x9gknd 3293 42 as as IN cord-010119-t1x9gknd 3293 43 they -PRON- PRP cord-010119-t1x9gknd 3293 44 age age VBP cord-010119-t1x9gknd 3293 45 . . . cord-010119-t1x9gknd 3294 1 If if IN cord-010119-t1x9gknd 3294 2 proven prove VBN cord-010119-t1x9gknd 3294 3 , , , cord-010119-t1x9gknd 3294 4 this this DT cord-010119-t1x9gknd 3294 5 data data NN cord-010119-t1x9gknd 3294 6 would would MD cord-010119-t1x9gknd 3294 7 suggest suggest VB cord-010119-t1x9gknd 3294 8 there there EX cord-010119-t1x9gknd 3294 9 are be VBP cord-010119-t1x9gknd 3294 10 genetic genetic JJ cord-010119-t1x9gknd 3294 11 factors factor NNS cord-010119-t1x9gknd 3294 12 that that WDT cord-010119-t1x9gknd 3294 13 modulate modulate VBP cord-010119-t1x9gknd 3294 14 a a DT cord-010119-t1x9gknd 3294 15 person person NN cord-010119-t1x9gknd 3294 16 's 's POS cord-010119-t1x9gknd 3294 17 ability ability NN cord-010119-t1x9gknd 3294 18 to to TO cord-010119-t1x9gknd 3294 19 mobilize mobilize VB cord-010119-t1x9gknd 3294 20 stem stem NN cord-010119-t1x9gknd 3294 21 cells cell NNS cord-010119-t1x9gknd 3294 22 as as IN cord-010119-t1x9gknd 3294 23 they -PRON- PRP cord-010119-t1x9gknd 3294 24 age age VBP cord-010119-t1x9gknd 3294 25 and and CC cord-010119-t1x9gknd 3294 26 that that IN cord-010119-t1x9gknd 3294 27 these these DT cord-010119-t1x9gknd 3294 28 genetic genetic JJ cord-010119-t1x9gknd 3294 29 factors factor NNS cord-010119-t1x9gknd 3294 30 differ differ VBP cord-010119-t1x9gknd 3294 31 between between IN cord-010119-t1x9gknd 3294 32 ethnic ethnic JJ cord-010119-t1x9gknd 3294 33 groups group NNS cord-010119-t1x9gknd 3294 34 . . . cord-010119-t1x9gknd 3295 1 This this DT cord-010119-t1x9gknd 3295 2 small small JJ cord-010119-t1x9gknd 3295 3 data datum NNS cord-010119-t1x9gknd 3295 4 set set NN cord-010119-t1x9gknd 3295 5 would would MD cord-010119-t1x9gknd 3295 6 suggest suggest VB cord-010119-t1x9gknd 3295 7 that that IN cord-010119-t1x9gknd 3295 8 people people NNS cord-010119-t1x9gknd 3295 9 of of IN cord-010119-t1x9gknd 3295 10 Hispanic hispanic JJ cord-010119-t1x9gknd 3295 11 ethnicity ethnicity NN cord-010119-t1x9gknd 3295 12 maintain maintain VBP cord-010119-t1x9gknd 3295 13 a a DT cord-010119-t1x9gknd 3295 14 more more RBR cord-010119-t1x9gknd 3295 15 robust robust JJ cord-010119-t1x9gknd 3295 16 and and CC cord-010119-t1x9gknd 3295 17 quickly quickly RB cord-010119-t1x9gknd 3295 18 responsive responsive JJ cord-010119-t1x9gknd 3295 19 stem stem NN cord-010119-t1x9gknd 3295 20 cell cell NN cord-010119-t1x9gknd 3295 21 pool pool NN cord-010119-t1x9gknd 3295 22 , , , cord-010119-t1x9gknd 3295 23 even even RB cord-010119-t1x9gknd 3295 24 as as IN cord-010119-t1x9gknd 3295 25 they -PRON- PRP cord-010119-t1x9gknd 3295 26 age age VBP cord-010119-t1x9gknd 3295 27 . . . cord-010119-t1x9gknd 3296 1 Further further JJ cord-010119-t1x9gknd 3296 2 studies study NNS cord-010119-t1x9gknd 3296 3 of of IN cord-010119-t1x9gknd 3296 4 larger large JJR cord-010119-t1x9gknd 3296 5 cohorts cohort NNS cord-010119-t1x9gknd 3296 6 are be VBP cord-010119-t1x9gknd 3296 7 needed need VBN cord-010119-t1x9gknd 3296 8 to to TO cord-010119-t1x9gknd 3296 9 validate validate VB cord-010119-t1x9gknd 3296 10 this this DT cord-010119-t1x9gknd 3296 11 observation observation NN cord-010119-t1x9gknd 3296 12 . . . cord-010119-t1x9gknd 3297 1 If if IN cord-010119-t1x9gknd 3297 2 proven prove VBN cord-010119-t1x9gknd 3297 3 , , , cord-010119-t1x9gknd 3297 4 this this DT cord-010119-t1x9gknd 3297 5 has have VBZ cord-010119-t1x9gknd 3297 6 far far RB cord-010119-t1x9gknd 3297 7 reaching reach VBG cord-010119-t1x9gknd 3297 8 implications implication NNS cord-010119-t1x9gknd 3297 9 within within IN cord-010119-t1x9gknd 3297 10 the the DT cord-010119-t1x9gknd 3297 11 stem stem NN cord-010119-t1x9gknd 3297 12 cell cell NN cord-010119-t1x9gknd 3297 13 research research NN cord-010119-t1x9gknd 3297 14 and and CC cord-010119-t1x9gknd 3297 15 therapy therapy NN cord-010119-t1x9gknd 3297 16 arena arena NN cord-010119-t1x9gknd 3297 17 . . . cord-010119-t1x9gknd 3298 1 Background Background NNP cord-010119-t1x9gknd 3298 2 / / SYM cord-010119-t1x9gknd 3298 3 Case Case NNP cord-010119-t1x9gknd 3298 4 Studies Studies NNPS cord-010119-t1x9gknd 3298 5 : : : cord-010119-t1x9gknd 3299 1 An an DT cord-010119-t1x9gknd 3299 2 update update NN cord-010119-t1x9gknd 3299 3 in in IN cord-010119-t1x9gknd 3299 4 HPC HPC NNP cord-010119-t1x9gknd 3299 5 apheresis apheresis NN cord-010119-t1x9gknd 3299 6 collection collection NN cord-010119-t1x9gknd 3299 7 software software NN cord-010119-t1x9gknd 3299 8 led lead VBD cord-010119-t1x9gknd 3299 9 to to IN cord-010119-t1x9gknd 3299 10 higher high JJR cord-010119-t1x9gknd 3299 11 collection collection NN cord-010119-t1x9gknd 3299 12 volume volume NN cord-010119-t1x9gknd 3299 13 in in IN cord-010119-t1x9gknd 3299 14 the the DT cord-010119-t1x9gknd 3299 15 organization organization NN cord-010119-t1x9gknd 3299 16 's 's POS cord-010119-t1x9gknd 3299 17 human human JJ cord-010119-t1x9gknd 3299 18 progenitor progenitor NN cord-010119-t1x9gknd 3299 19 cell cell NN cord-010119-t1x9gknd 3299 20 ( ( -LRB- cord-010119-t1x9gknd 3299 21 HPC HPC NNP cord-010119-t1x9gknd 3299 22 ) ) -RRB- cord-010119-t1x9gknd 3299 23 products product NNS cord-010119-t1x9gknd 3299 24 without without IN cord-010119-t1x9gknd 3299 25 a a DT cord-010119-t1x9gknd 3299 26 corresponding corresponding JJ cord-010119-t1x9gknd 3299 27 increase increase NN cord-010119-t1x9gknd 3299 28 in in IN cord-010119-t1x9gknd 3299 29 total total JJ cord-010119-t1x9gknd 3299 30 cellular cellular JJ cord-010119-t1x9gknd 3299 31 counts count NNS cord-010119-t1x9gknd 3299 32 . . . cord-010119-t1x9gknd 3300 1 Incorporation incorporation NN cord-010119-t1x9gknd 3300 2 of of IN cord-010119-t1x9gknd 3300 3 a a DT cord-010119-t1x9gknd 3300 4 volume volume NN cord-010119-t1x9gknd 3300 5 reduction reduction NN cord-010119-t1x9gknd 3300 6 step step NN cord-010119-t1x9gknd 3300 7 was be VBD cord-010119-t1x9gknd 3300 8 therefore therefore RB cord-010119-t1x9gknd 3300 9 warranted warrant VBN cord-010119-t1x9gknd 3300 10 as as IN cord-010119-t1x9gknd 3300 11 larger large JJR cord-010119-t1x9gknd 3300 12 product product NN cord-010119-t1x9gknd 3300 13 volumes volume NNS cord-010119-t1x9gknd 3300 14 require require VBP cord-010119-t1x9gknd 3300 15 additional additional JJ cord-010119-t1x9gknd 3300 16 time time NN cord-010119-t1x9gknd 3300 17 to to TO cord-010119-t1x9gknd 3300 18 transfuse transfuse VB cord-010119-t1x9gknd 3300 19 and and CC cord-010119-t1x9gknd 3300 20 lead lead VB cord-010119-t1x9gknd 3300 21 to to IN cord-010119-t1x9gknd 3300 22 a a DT cord-010119-t1x9gknd 3300 23 larger large JJR cord-010119-t1x9gknd 3300 24 DMSO DMSO NNP cord-010119-t1x9gknd 3300 25 load load NN cord-010119-t1x9gknd 3300 26 to to IN cord-010119-t1x9gknd 3300 27 the the DT cord-010119-t1x9gknd 3300 28 recipient recipient NN cord-010119-t1x9gknd 3300 29 , , , cord-010119-t1x9gknd 3300 30 often often RB cord-010119-t1x9gknd 3300 31 resulting result VBG cord-010119-t1x9gknd 3300 32 in in IN cord-010119-t1x9gknd 3300 33 the the DT cord-010119-t1x9gknd 3300 34 need need NN cord-010119-t1x9gknd 3300 35 to to TO cord-010119-t1x9gknd 3300 36 transfuse transfuse VB cord-010119-t1x9gknd 3300 37 over over IN cord-010119-t1x9gknd 3300 38 several several JJ cord-010119-t1x9gknd 3300 39 days day NNS cord-010119-t1x9gknd 3300 40 . . . cord-010119-t1x9gknd 3301 1 The the DT cord-010119-t1x9gknd 3301 2 objectives objective NNS cord-010119-t1x9gknd 3301 3 of of IN cord-010119-t1x9gknd 3301 4 this this DT cord-010119-t1x9gknd 3301 5 study study NN cord-010119-t1x9gknd 3301 6 were be VBD cord-010119-t1x9gknd 3301 7 to to TO cord-010119-t1x9gknd 3301 8 develop develop VB cord-010119-t1x9gknd 3301 9 suitable suitable JJ cord-010119-t1x9gknd 3301 10 mock mock JJ cord-010119-t1x9gknd 3301 11 HPC HPC NNP cord-010119-t1x9gknd 3301 12 ( ( -LRB- cord-010119-t1x9gknd 3301 13 mHPC mHPC NNP cord-010119-t1x9gknd 3301 14 ) ) -RRB- cord-010119-t1x9gknd 3301 15 products product NNS cord-010119-t1x9gknd 3301 16 and and CC cord-010119-t1x9gknd 3301 17 evaluate evaluate VB cord-010119-t1x9gknd 3301 18 the the DT cord-010119-t1x9gknd 3301 19 effectiveness effectiveness NN cord-010119-t1x9gknd 3301 20 of of IN cord-010119-t1x9gknd 3301 21 the the DT cord-010119-t1x9gknd 3301 22 BioSafe BioSafe NNP cord-010119-t1x9gknd 3301 23 PeriCell PeriCell NNP cord-010119-t1x9gknd 3301 24 volume volume NN cord-010119-t1x9gknd 3301 25 reduction reduction NN cord-010119-t1x9gknd 3301 26 technology technology NN cord-010119-t1x9gknd 3301 27 on on IN cord-010119-t1x9gknd 3301 28 white white JJ cord-010119-t1x9gknd 3301 29 blood blood NN cord-010119-t1x9gknd 3301 30 cell cell NN cord-010119-t1x9gknd 3301 31 ( ( -LRB- cord-010119-t1x9gknd 3301 32 WBC WBC NNP cord-010119-t1x9gknd 3301 33 ) ) -RRB- cord-010119-t1x9gknd 3301 34 recovery recovery NN cord-010119-t1x9gknd 3301 35 and and CC cord-010119-t1x9gknd 3301 36 viability viability NN cord-010119-t1x9gknd 3301 37 . . . cord-010119-t1x9gknd 3302 1 Study Study NNP cord-010119-t1x9gknd 3302 2 Design Design NNP cord-010119-t1x9gknd 3302 3 / / SYM cord-010119-t1x9gknd 3302 4 Method method NN cord-010119-t1x9gknd 3302 5 : : : cord-010119-t1x9gknd 3303 1 HPC HPC NNP cord-010119-t1x9gknd 3303 2 products product NNS cord-010119-t1x9gknd 3303 3 are be VBP cord-010119-t1x9gknd 3303 4 not not RB cord-010119-t1x9gknd 3303 5 readily readily RB cord-010119-t1x9gknd 3303 6 available available JJ cord-010119-t1x9gknd 3303 7 for for IN cord-010119-t1x9gknd 3303 8 development development NN cord-010119-t1x9gknd 3303 9 . . . cord-010119-t1x9gknd 3304 1 mHPC mHPC NNP cord-010119-t1x9gknd 3304 2 were be VBD cord-010119-t1x9gknd 3304 3 created create VBN cord-010119-t1x9gknd 3304 4 from from IN cord-010119-t1x9gknd 3304 5 whole whole JJ cord-010119-t1x9gknd 3304 6 blood blood NN cord-010119-t1x9gknd 3304 7 buffy buffy NNP cord-010119-t1x9gknd 3304 8 coats coat NNS cord-010119-t1x9gknd 3304 9 ( ( -LRB- cord-010119-t1x9gknd 3304 10 BCs BCs NNP cord-010119-t1x9gknd 3304 11 ) ) -RRB- cord-010119-t1x9gknd 3304 12 . . . cord-010119-t1x9gknd 3305 1 Fresh fresh JJ cord-010119-t1x9gknd 3305 2 ABO ABO NNP cord-010119-t1x9gknd 3305 3 compatible compatible JJ cord-010119-t1x9gknd 3305 4 BCs bc NNS cord-010119-t1x9gknd 3305 5 were be VBD cord-010119-t1x9gknd 3305 6 pooled pool VBN cord-010119-t1x9gknd 3305 7 and and CC cord-010119-t1x9gknd 3305 8 concentrated concentrate VBD cord-010119-t1x9gknd 3305 9 using use VBG cord-010119-t1x9gknd 3305 10 centrifugation centrifugation NN cord-010119-t1x9gknd 3305 11 and and CC cord-010119-t1x9gknd 3305 12 manual manual JJ cord-010119-t1x9gknd 3305 13 extraction extraction NN cord-010119-t1x9gknd 3305 14 of of IN cord-010119-t1x9gknd 3305 15 supernatant supernatant JJ cord-010119-t1x9gknd 3305 16 and and CC cord-010119-t1x9gknd 3305 17 red red JJ cord-010119-t1x9gknd 3305 18 cells cell NNS cord-010119-t1x9gknd 3305 19 . . . cord-010119-t1x9gknd 3306 1 The the DT cord-010119-t1x9gknd 3306 2 mHPC mhpc JJ cord-010119-t1x9gknd 3306 3 products product NNS cord-010119-t1x9gknd 3306 4 were be VBD cord-010119-t1x9gknd 3306 5 then then RB cord-010119-t1x9gknd 3306 6 diluted dilute VBN cord-010119-t1x9gknd 3306 7 in in IN cord-010119-t1x9gknd 3306 8 plasma plasma NN cord-010119-t1x9gknd 3306 9 to to TO cord-010119-t1x9gknd 3306 10 produce produce VB cord-010119-t1x9gknd 3306 11 an an DT cord-010119-t1x9gknd 3306 12 appropriate appropriate JJ cord-010119-t1x9gknd 3306 13 concentration concentration NN cord-010119-t1x9gknd 3306 14 and and CC cord-010119-t1x9gknd 3306 15 volume volume NN cord-010119-t1x9gknd 3306 16 . . . cord-010119-t1x9gknd 3307 1 HPC HPC NNP cord-010119-t1x9gknd 3307 2 collection collection NN cord-010119-t1x9gknd 3307 3 data datum NNS cord-010119-t1x9gknd 3307 4 from from IN cord-010119-t1x9gknd 3307 5 last last JJ cord-010119-t1x9gknd 3307 6 3 3 CD cord-010119-t1x9gknd 3307 7 years year NNS cord-010119-t1x9gknd 3307 8 was be VBD cord-010119-t1x9gknd 3307 9 analyzed analyze VBN cord-010119-t1x9gknd 3307 10 to to TO cord-010119-t1x9gknd 3307 11 determine determine VB cord-010119-t1x9gknd 3307 12 the the DT cord-010119-t1x9gknd 3307 13 95 95 CD cord-010119-t1x9gknd 3307 14 th th XX cord-010119-t1x9gknd 3307 15 percentile percentile JJ cord-010119-t1x9gknd 3307 16 , , , cord-010119-t1x9gknd 3307 17 median median NN cord-010119-t1x9gknd 3307 18 and and CC cord-010119-t1x9gknd 3307 19 5 5 CD cord-010119-t1x9gknd 3307 20 th th XX cord-010119-t1x9gknd 3307 21 percentile percentile JJ cord-010119-t1x9gknd 3307 22 values value NNS cord-010119-t1x9gknd 3307 23 for for IN cord-010119-t1x9gknd 3307 24 both both DT cord-010119-t1x9gknd 3307 25 HPC HPC NNP cord-010119-t1x9gknd 3307 26 volume volume NN cord-010119-t1x9gknd 3307 27 and and CC cord-010119-t1x9gknd 3307 28 WBC WBC NNP cord-010119-t1x9gknd 3307 29 concentration concentration NN cord-010119-t1x9gknd 3307 30 . . . cord-010119-t1x9gknd 3308 1 Six six CD cord-010119-t1x9gknd 3308 2 mHPC mHPC NNS cord-010119-t1x9gknd 3308 3 products product NNS cord-010119-t1x9gknd 3308 4 were be VBD cord-010119-t1x9gknd 3308 5 tested test VBN cord-010119-t1x9gknd 3308 6 ; ; : cord-010119-t1x9gknd 3308 7 three three CD cord-010119-t1x9gknd 3308 8 high high JJ cord-010119-t1x9gknd 3308 9 WBC WBC NNP cord-010119-t1x9gknd 3308 10 ( ( -LRB- cord-010119-t1x9gknd 3308 11 234 234 CD cord-010119-t1x9gknd 3308 12 x x SYM cord-010119-t1x9gknd 3308 13 10 10 CD cord-010119-t1x9gknd 3308 14 6 6 CD cord-010119-t1x9gknd 3308 15 cell cell NN cord-010119-t1x9gknd 3308 16 / / SYM cord-010119-t1x9gknd 3308 17 mL ml NN cord-010119-t1x9gknd 3308 18 ) ) -RRB- cord-010119-t1x9gknd 3308 19 and and CC cord-010119-t1x9gknd 3308 20 three three CD cord-010119-t1x9gknd 3308 21 low low JJ cord-010119-t1x9gknd 3308 22 WBC WBC NNP cord-010119-t1x9gknd 3308 23 ( ( -LRB- cord-010119-t1x9gknd 3308 24 114 114 CD cord-010119-t1x9gknd 3308 25 x x SYM cord-010119-t1x9gknd 3308 26 10 10 CD cord-010119-t1x9gknd 3308 27 6 6 CD cord-010119-t1x9gknd 3308 28 cells cell NNS cord-010119-t1x9gknd 3308 29 / / SYM cord-010119-t1x9gknd 3308 30 mL ml NN cord-010119-t1x9gknd 3308 31 ) ) -RRB- cord-010119-t1x9gknd 3308 32 concentrations concentration NNS cord-010119-t1x9gknd 3308 33 , , , cord-010119-t1x9gknd 3308 34 each each DT cord-010119-t1x9gknd 3308 35 at at IN cord-010119-t1x9gknd 3308 36 high high JJ cord-010119-t1x9gknd 3308 37 ( ( -LRB- cord-010119-t1x9gknd 3308 38 505 505 CD cord-010119-t1x9gknd 3308 39 mL ml NN cord-010119-t1x9gknd 3308 40 ) ) -RRB- cord-010119-t1x9gknd 3308 41 , , , cord-010119-t1x9gknd 3308 42 low low JJ cord-010119-t1x9gknd 3308 43 ( ( -LRB- cord-010119-t1x9gknd 3308 44 265 265 CD cord-010119-t1x9gknd 3308 45 mL ml NN cord-010119-t1x9gknd 3308 46 ) ) -RRB- cord-010119-t1x9gknd 3308 47 and and CC cord-010119-t1x9gknd 3308 48 median median NN cord-010119-t1x9gknd 3308 49 ( ( -LRB- cord-010119-t1x9gknd 3308 50 355 355 CD cord-010119-t1x9gknd 3308 51 mL ml NN cord-010119-t1x9gknd 3308 52 ) ) -RRB- cord-010119-t1x9gknd 3308 53 volumes volume NNS cord-010119-t1x9gknd 3308 54 . . . cord-010119-t1x9gknd 3309 1 Each each DT cord-010119-t1x9gknd 3309 2 unit unit NN cord-010119-t1x9gknd 3309 3 was be VBD cord-010119-t1x9gknd 3309 4 processed process VBN cord-010119-t1x9gknd 3309 5 sequentially sequentially RB cord-010119-t1x9gknd 3309 6 from from IN cord-010119-t1x9gknd 3309 7 high high JJ cord-010119-t1x9gknd 3309 8 , , , cord-010119-t1x9gknd 3309 9 median median JJ cord-010119-t1x9gknd 3309 10 and and CC cord-010119-t1x9gknd 3309 11 low low JJ cord-010119-t1x9gknd 3309 12 volumes volume NNS cord-010119-t1x9gknd 3309 13 . . . cord-010119-t1x9gknd 3310 1 Hence hence RB cord-010119-t1x9gknd 3310 2 , , , cord-010119-t1x9gknd 3310 3 the the DT cord-010119-t1x9gknd 3310 4 highest high JJS cord-010119-t1x9gknd 3310 5 mHPC mhpc JJ cord-010119-t1x9gknd 3310 6 volume volume NN cord-010119-t1x9gknd 3310 7 was be VBD cord-010119-t1x9gknd 3310 8 processed process VBN cord-010119-t1x9gknd 3310 9 for for IN cord-010119-t1x9gknd 3310 10 volume volume NN cord-010119-t1x9gknd 3310 11 reduction reduction NN cord-010119-t1x9gknd 3310 12 first first RB cord-010119-t1x9gknd 3310 13 with with IN cord-010119-t1x9gknd 3310 14 a a DT cord-010119-t1x9gknd 3310 15 Sepax Sepax NNP cord-010119-t1x9gknd 3310 16 2 2 CD cord-010119-t1x9gknd 3310 17 ( ( -LRB- cord-010119-t1x9gknd 3310 18 PeriCell PeriCell NNP cord-010119-t1x9gknd 3310 19 Protocol Protocol NNP cord-010119-t1x9gknd 3310 20 , , , cord-010119-t1x9gknd 3310 21 CS.430.1 cs.430.1 NN cord-010119-t1x9gknd 3310 22 kits kit NNS cord-010119-t1x9gknd 3310 23 ) ) -RRB- cord-010119-t1x9gknd 3310 24 , , , cord-010119-t1x9gknd 3310 25 analyzed analyze VBD cord-010119-t1x9gknd 3310 26 and and CC cord-010119-t1x9gknd 3310 27 then then RB cord-010119-t1x9gknd 3310 28 reconstituted reconstitute VBN cord-010119-t1x9gknd 3310 29 and and CC cord-010119-t1x9gknd 3310 30 volume volume NN cord-010119-t1x9gknd 3310 31 adjusted adjust VBN cord-010119-t1x9gknd 3310 32 to to IN cord-010119-t1x9gknd 3310 33 the the DT cord-010119-t1x9gknd 3310 34 next next JJ cord-010119-t1x9gknd 3310 35 volume volume NN cord-010119-t1x9gknd 3310 36 target target NN cord-010119-t1x9gknd 3310 37 before before IN cord-010119-t1x9gknd 3310 38 being be VBG cord-010119-t1x9gknd 3310 39 volume volume NN cord-010119-t1x9gknd 3310 40 reduced reduce VBN cord-010119-t1x9gknd 3310 41 again again RB cord-010119-t1x9gknd 3310 42 , , , cord-010119-t1x9gknd 3310 43 and and CC cord-010119-t1x9gknd 3310 44 so so RB cord-010119-t1x9gknd 3310 45 forth forth RB cord-010119-t1x9gknd 3310 46 . . . cord-010119-t1x9gknd 3311 1 One one CD cord-010119-t1x9gknd 3311 2 additional additional JJ cord-010119-t1x9gknd 3311 3 mock mock JJ cord-010119-t1x9gknd 3311 4 product product NN cord-010119-t1x9gknd 3311 5 was be VBD cord-010119-t1x9gknd 3311 6 prepared prepare VBN cord-010119-t1x9gknd 3311 7 for for IN cord-010119-t1x9gknd 3311 8 a a DT cord-010119-t1x9gknd 3311 9 reproducibility reproducibility NN cord-010119-t1x9gknd 3311 10 study study NN cord-010119-t1x9gknd 3311 11 and and CC cord-010119-t1x9gknd 3311 12 was be VBD cord-010119-t1x9gknd 3311 13 volume volume NN cord-010119-t1x9gknd 3311 14 reduced reduce VBN cord-010119-t1x9gknd 3311 15 three three CD cord-010119-t1x9gknd 3311 16 times time NNS cord-010119-t1x9gknd 3311 17 . . . cord-010119-t1x9gknd 3312 1 WBC WBC NNP cord-010119-t1x9gknd 3312 2 concentration concentration NN cord-010119-t1x9gknd 3312 3 and and CC cord-010119-t1x9gknd 3312 4 7-AAD 7-aad CD cord-010119-t1x9gknd 3312 5 viability viability NN cord-010119-t1x9gknd 3312 6 was be VBD cord-010119-t1x9gknd 3312 7 determined determine VBN cord-010119-t1x9gknd 3312 8 before before IN cord-010119-t1x9gknd 3312 9 and and CC cord-010119-t1x9gknd 3312 10 after after IN cord-010119-t1x9gknd 3312 11 each each DT cord-010119-t1x9gknd 3312 12 volume volume NN cord-010119-t1x9gknd 3312 13 reduction reduction NN cord-010119-t1x9gknd 3312 14 . . . cord-010119-t1x9gknd 3313 1 A a DT cord-010119-t1x9gknd 3313 2 control control NN cord-010119-t1x9gknd 3313 3 sample sample NN cord-010119-t1x9gknd 3313 4 was be VBD cord-010119-t1x9gknd 3313 5 removed remove VBN cord-010119-t1x9gknd 3313 6 from from IN cord-010119-t1x9gknd 3313 7 the the DT cord-010119-t1x9gknd 3313 8 product product NN cord-010119-t1x9gknd 3313 9 prior prior RB cord-010119-t1x9gknd 3313 10 to to IN cord-010119-t1x9gknd 3313 11 processing processing NN cord-010119-t1x9gknd 3313 12 and and CC cord-010119-t1x9gknd 3313 13 sat sit VBD cord-010119-t1x9gknd 3313 14 on on IN cord-010119-t1x9gknd 3313 15 the the DT cord-010119-t1x9gknd 3313 16 bench bench NN cord-010119-t1x9gknd 3313 17 top top NN cord-010119-t1x9gknd 3313 18 until until IN cord-010119-t1x9gknd 3313 19 the the DT cord-010119-t1x9gknd 3313 20 end end NN cord-010119-t1x9gknd 3313 21 of of IN cord-010119-t1x9gknd 3313 22 the the DT cord-010119-t1x9gknd 3313 23 protocol protocol NN cord-010119-t1x9gknd 3313 24 to to TO cord-010119-t1x9gknd 3313 25 assess assess VB cord-010119-t1x9gknd 3313 26 the the DT cord-010119-t1x9gknd 3313 27 change change NN cord-010119-t1x9gknd 3313 28 in in IN cord-010119-t1x9gknd 3313 29 cell cell NN cord-010119-t1x9gknd 3313 30 concentration concentration NN cord-010119-t1x9gknd 3313 31 and and CC cord-010119-t1x9gknd 3313 32 viability viability NN cord-010119-t1x9gknd 3313 33 over over IN cord-010119-t1x9gknd 3313 34 time time NN cord-010119-t1x9gknd 3313 35 . . . cord-010119-t1x9gknd 3314 1 Results/ Results/ . cord-010119-t1x9gknd 3315 1 Finding find VBG cord-010119-t1x9gknd 3315 2 : : : cord-010119-t1x9gknd 3315 3 Mock Mock NNP cord-010119-t1x9gknd 3315 4 HPC HPC NNP cord-010119-t1x9gknd 3315 5 products product NNS cord-010119-t1x9gknd 3315 6 had have VBD cord-010119-t1x9gknd 3315 7 a a DT cord-010119-t1x9gknd 3315 8 mean mean NN cord-010119-t1x9gknd 3315 9 starting start VBG cord-010119-t1x9gknd 3315 10 7-AAD 7-aad CD cord-010119-t1x9gknd 3315 11 viability viability NN cord-010119-t1x9gknd 3315 12 of of IN cord-010119-t1x9gknd 3315 13 76 76 CD cord-010119-t1x9gknd 3315 14 6 6 CD cord-010119-t1x9gknd 3315 15 8 8 CD cord-010119-t1x9gknd 3315 16 % % NN cord-010119-t1x9gknd 3316 1 [ [ -LRB- cord-010119-t1x9gknd 3316 2 range range NNP cord-010119-t1x9gknd 3316 3 64 64 CD cord-010119-t1x9gknd 3316 4 - - HYPH cord-010119-t1x9gknd 3316 5 85]% 85]% NN cord-010119-t1x9gknd 3316 6 and and CC cord-010119-t1x9gknd 3316 7 a a DT cord-010119-t1x9gknd 3316 8 hematocrit hematocrit NN cord-010119-t1x9gknd 3316 9 of of IN cord-010119-t1x9gknd 3316 10 14 14 CD cord-010119-t1x9gknd 3316 11 6 6 CD cord-010119-t1x9gknd 3316 12 5 5 CD cord-010119-t1x9gknd 3316 13 % % NN cord-010119-t1x9gknd 3316 14 [ [ -LRB- cord-010119-t1x9gknd 3316 15 9 9 CD cord-010119-t1x9gknd 3316 16 - - SYM cord-010119-t1x9gknd 3316 17 19 19 CD cord-010119-t1x9gknd 3316 18 ] ] -RRB- cord-010119-t1x9gknd 3316 19 which which WDT cord-010119-t1x9gknd 3316 20 is be VBZ cord-010119-t1x9gknd 3316 21 well well RB cord-010119-t1x9gknd 3316 22 below below IN cord-010119-t1x9gknd 3316 23 the the DT cord-010119-t1x9gknd 3316 24 maximum maximum JJ cord-010119-t1x9gknd 3316 25 allowable allowable JJ cord-010119-t1x9gknd 3316 26 limit limit NN cord-010119-t1x9gknd 3316 27 of of IN cord-010119-t1x9gknd 3316 28 the the DT cord-010119-t1x9gknd 3316 29 PeriCell PeriCell NNP cord-010119-t1x9gknd 3316 30 . . . cord-010119-t1x9gknd 3317 1 No no DT cord-010119-t1x9gknd 3317 2 significant significant JJ cord-010119-t1x9gknd 3317 3 differences difference NNS cord-010119-t1x9gknd 3317 4 in in IN cord-010119-t1x9gknd 3317 5 WBC WBC NNP cord-010119-t1x9gknd 3317 6 recovery recovery NN cord-010119-t1x9gknd 3317 7 or or CC cord-010119-t1x9gknd 3317 8 change change NN cord-010119-t1x9gknd 3317 9 in in IN cord-010119-t1x9gknd 3317 10 viability viability NN cord-010119-t1x9gknd 3317 11 were be VBD cord-010119-t1x9gknd 3317 12 seen see VBN cord-010119-t1x9gknd 3317 13 between between IN cord-010119-t1x9gknd 3317 14 the the DT cord-010119-t1x9gknd 3317 15 6 6 CD cord-010119-t1x9gknd 3317 16 mHPC mHPC NNS cord-010119-t1x9gknd 3317 17 products product NNS cord-010119-t1x9gknd 3317 18 . . . cord-010119-t1x9gknd 3318 1 Aggregate aggregate JJ cord-010119-t1x9gknd 3318 2 data datum NNS cord-010119-t1x9gknd 3318 3 showed show VBD cord-010119-t1x9gknd 3318 4 that that IN cord-010119-t1x9gknd 3318 5 the the DT cord-010119-t1x9gknd 3318 6 mean mean JJ cord-010119-t1x9gknd 3318 7 WBC WBC NNP cord-010119-t1x9gknd 3318 8 recovery recovery NN cord-010119-t1x9gknd 3318 9 of of IN cord-010119-t1x9gknd 3318 10 the the DT cord-010119-t1x9gknd 3318 11 volume volume NN cord-010119-t1x9gknd 3318 12 reduction reduction NN cord-010119-t1x9gknd 3318 13 process process NN cord-010119-t1x9gknd 3318 14 was be VBD cord-010119-t1x9gknd 3318 15 97 97 CD cord-010119-t1x9gknd 3318 16 6 6 CD cord-010119-t1x9gknd 3318 17 8 8 CD cord-010119-t1x9gknd 3318 18 % % NN cord-010119-t1x9gknd 3318 19 [ [ -LRB- cord-010119-t1x9gknd 3318 20 64 64 CD cord-010119-t1x9gknd 3318 21 - - SYM cord-010119-t1x9gknd 3318 22 105 105 CD cord-010119-t1x9gknd 3318 23 ] ] -RRB- cord-010119-t1x9gknd 3318 24 with with IN cord-010119-t1x9gknd 3318 25 a a DT cord-010119-t1x9gknd 3318 26 3 3 CD cord-010119-t1x9gknd 3318 27 6 6 CD cord-010119-t1x9gknd 3318 28 3 3 CD cord-010119-t1x9gknd 3318 29 % % NN cord-010119-t1x9gknd 3318 30 [ [ -LRB- cord-010119-t1x9gknd 3318 31 -2 -2 CD cord-010119-t1x9gknd 3318 32 - - HYPH cord-010119-t1x9gknd 3318 33 11 11 CD cord-010119-t1x9gknd 3318 34 ] ] -RRB- cord-010119-t1x9gknd 3318 35 change change NN cord-010119-t1x9gknd 3318 36 in in IN cord-010119-t1x9gknd 3318 37 viability viability NN cord-010119-t1x9gknd 3318 38 . . . cord-010119-t1x9gknd 3319 1 The the DT cord-010119-t1x9gknd 3319 2 recovery recovery NN cord-010119-t1x9gknd 3319 3 protocol protocol NN cord-010119-t1x9gknd 3319 4 used use VBN cord-010119-t1x9gknd 3319 5 to to TO cord-010119-t1x9gknd 3319 6 salvage salvage VB cord-010119-t1x9gknd 3319 7 product product NN cord-010119-t1x9gknd 3319 8 after after IN cord-010119-t1x9gknd 3319 9 each each DT cord-010119-t1x9gknd 3319 10 volume volume NN cord-010119-t1x9gknd 3319 11 reduction reduction NN cord-010119-t1x9gknd 3319 12 gave give VBD cord-010119-t1x9gknd 3319 13 a a DT cord-010119-t1x9gknd 3319 14 recovery recovery NN cord-010119-t1x9gknd 3319 15 of of IN cord-010119-t1x9gknd 3319 16 99 99 CD cord-010119-t1x9gknd 3319 17 6 6 CD cord-010119-t1x9gknd 3319 18 4 4 CD cord-010119-t1x9gknd 3319 19 [ [ -LRB- cord-010119-t1x9gknd 3319 20 92 92 CD cord-010119-t1x9gknd 3319 21 , , , cord-010119-t1x9gknd 3319 22 104 104 CD cord-010119-t1x9gknd 3319 23 ] ] -RRB- cord-010119-t1x9gknd 3319 24 % % NN cord-010119-t1x9gknd 3319 25 and and CC cord-010119-t1x9gknd 3319 26 a a DT cord-010119-t1x9gknd 3319 27 change change NN cord-010119-t1x9gknd 3319 28 in in IN cord-010119-t1x9gknd 3319 29 7-AAD 7-aad CD cord-010119-t1x9gknd 3319 30 viability viability NN cord-010119-t1x9gknd 3319 31 of of IN cord-010119-t1x9gknd 3319 32 2 2 CD cord-010119-t1x9gknd 3319 33 6 6 CD cord-010119-t1x9gknd 3319 34 2 2 CD cord-010119-t1x9gknd 3319 35 [ [ -LRB- cord-010119-t1x9gknd 3319 36 0 0 CD cord-010119-t1x9gknd 3319 37 , , , cord-010119-t1x9gknd 3319 38 11 11 CD cord-010119-t1x9gknd 3319 39 ] ] -RRB- cord-010119-t1x9gknd 3319 40 % % NN cord-010119-t1x9gknd 3319 41 from from IN cord-010119-t1x9gknd 3319 42 the the DT cord-010119-t1x9gknd 3319 43 input input NN cord-010119-t1x9gknd 3319 44 product product NN cord-010119-t1x9gknd 3319 45 . . . cord-010119-t1x9gknd 3320 1 The the DT cord-010119-t1x9gknd 3320 2 method method NN cord-010119-t1x9gknd 3320 3 was be VBD cord-010119-t1x9gknd 3320 4 found find VBN cord-010119-t1x9gknd 3320 5 to to TO cord-010119-t1x9gknd 3320 6 have have VB cord-010119-t1x9gknd 3320 7 a a DT cord-010119-t1x9gknd 3320 8 CV CV NNP cord-010119-t1x9gknd 3320 9 of of IN cord-010119-t1x9gknd 3320 10 2.0 2.0 CD cord-010119-t1x9gknd 3320 11 % % NN cord-010119-t1x9gknd 3320 12 . . . cord-010119-t1x9gknd 3321 1 The the DT cord-010119-t1x9gknd 3321 2 change change NN cord-010119-t1x9gknd 3321 3 in in IN cord-010119-t1x9gknd 3321 4 WBC WBC NNP cord-010119-t1x9gknd 3321 5 concentration concentration NN cord-010119-t1x9gknd 3321 6 and and CC cord-010119-t1x9gknd 3321 7 WBC WBC NNP cord-010119-t1x9gknd 3321 8 viability viability NN cord-010119-t1x9gknd 3321 9 of of IN cord-010119-t1x9gknd 3321 10 the the DT cord-010119-t1x9gknd 3321 11 test test NN cord-010119-t1x9gknd 3321 12 products product NNS cord-010119-t1x9gknd 3321 13 was be VBD cord-010119-t1x9gknd 3321 14 not not RB cord-010119-t1x9gknd 3321 15 significantly significantly RB cord-010119-t1x9gknd 3321 16 different different JJ cord-010119-t1x9gknd 3321 17 from from IN cord-010119-t1x9gknd 3321 18 the the DT cord-010119-t1x9gknd 3321 19 unprocessed unprocessed JJ cord-010119-t1x9gknd 3321 20 control control NN cord-010119-t1x9gknd 3321 21 samples sample NNS cord-010119-t1x9gknd 3321 22 . . . cord-010119-t1x9gknd 3322 1 Conclusion conclusion NN cord-010119-t1x9gknd 3322 2 : : : cord-010119-t1x9gknd 3323 1 Mock Mock NNP cord-010119-t1x9gknd 3323 2 BC BC NNP cord-010119-t1x9gknd 3323 3 products product NNS cord-010119-t1x9gknd 3323 4 are be VBP cord-010119-t1x9gknd 3323 5 a a DT cord-010119-t1x9gknd 3323 6 suitable suitable JJ cord-010119-t1x9gknd 3323 7 alternative alternative NN cord-010119-t1x9gknd 3323 8 where where WRB cord-010119-t1x9gknd 3323 9 HPC HPC NNP cord-010119-t1x9gknd 3323 10 products product NNS cord-010119-t1x9gknd 3323 11 are be VBP cord-010119-t1x9gknd 3323 12 not not RB cord-010119-t1x9gknd 3323 13 available available JJ cord-010119-t1x9gknd 3323 14 for for IN cord-010119-t1x9gknd 3323 15 development development NN cord-010119-t1x9gknd 3323 16 and and CC cord-010119-t1x9gknd 3323 17 are be VBP cord-010119-t1x9gknd 3323 18 a a DT cord-010119-t1x9gknd 3323 19 good good JJ cord-010119-t1x9gknd 3323 20 use use NN cord-010119-t1x9gknd 3323 21 of of IN cord-010119-t1x9gknd 3323 22 product product NN cord-010119-t1x9gknd 3323 23 otherwise otherwise RB cord-010119-t1x9gknd 3323 24 directed direct VBN cord-010119-t1x9gknd 3323 25 for for IN cord-010119-t1x9gknd 3323 26 rejection rejection NN cord-010119-t1x9gknd 3323 27 and and CC cord-010119-t1x9gknd 3323 28 disposal disposal NN cord-010119-t1x9gknd 3323 29 . . . cord-010119-t1x9gknd 3324 1 The the DT cord-010119-t1x9gknd 3324 2 volume volume NN cord-010119-t1x9gknd 3324 3 reduction reduction NN cord-010119-t1x9gknd 3324 4 protocol protocol NN cord-010119-t1x9gknd 3324 5 evaluated evaluate VBN cord-010119-t1x9gknd 3324 6 had have VBD cord-010119-t1x9gknd 3324 7 minimal minimal JJ cord-010119-t1x9gknd 3324 8 impact impact NN cord-010119-t1x9gknd 3324 9 on on IN cord-010119-t1x9gknd 3324 10 the the DT cord-010119-t1x9gknd 3324 11 WBC WBC NNP cord-010119-t1x9gknd 3324 12 concentration concentration NN cord-010119-t1x9gknd 3324 13 and and CC cord-010119-t1x9gknd 3324 14 WBC WBC NNP cord-010119-t1x9gknd 3324 15 viability viability NN cord-010119-t1x9gknd 3324 16 in in IN cord-010119-t1x9gknd 3324 17 the the DT cord-010119-t1x9gknd 3324 18 mock mock JJ cord-010119-t1x9gknd 3324 19 products product NNS cord-010119-t1x9gknd 3324 20 and and CC cord-010119-t1x9gknd 3324 21 was be VBD cord-010119-t1x9gknd 3324 22 found find VBN cord-010119-t1x9gknd 3324 23 to to TO cord-010119-t1x9gknd 3324 24 be be VB cord-010119-t1x9gknd 3324 25 highly highly RB cord-010119-t1x9gknd 3324 26 reproducible reproducible JJ cord-010119-t1x9gknd 3324 27 , , , cord-010119-t1x9gknd 3324 28 giving give VBG cord-010119-t1x9gknd 3324 29 confidence confidence NN cord-010119-t1x9gknd 3324 30 that that IN cord-010119-t1x9gknd 3324 31 it -PRON- PRP cord-010119-t1x9gknd 3324 32 will will MD cord-010119-t1x9gknd 3324 33 be be VB cord-010119-t1x9gknd 3324 34 a a DT cord-010119-t1x9gknd 3324 35 valuable valuable JJ cord-010119-t1x9gknd 3324 36 processing processing NN cord-010119-t1x9gknd 3324 37 step step NN cord-010119-t1x9gknd 3324 38 with with IN cord-010119-t1x9gknd 3324 39 HPCs hpc NNS cord-010119-t1x9gknd 3324 40 and and CC cord-010119-t1x9gknd 3324 41 will will MD cord-010119-t1x9gknd 3324 42 facilitate facilitate VB cord-010119-t1x9gknd 3324 43 transfusion transfusion NN cord-010119-t1x9gknd 3324 44 of of IN cord-010119-t1x9gknd 3324 45 HPC HPC NNP cord-010119-t1x9gknd 3324 46 products product NNS cord-010119-t1x9gknd 3324 47 into into IN cord-010119-t1x9gknd 3324 48 the the DT cord-010119-t1x9gknd 3324 49 recipient recipient NN cord-010119-t1x9gknd 3324 50 . . . cord-010119-t1x9gknd 3325 1 The the DT cord-010119-t1x9gknd 3325 2 protocol protocol NN cord-010119-t1x9gknd 3325 3 is be VBZ cord-010119-t1x9gknd 3325 4 now now RB cord-010119-t1x9gknd 3325 5 in in IN cord-010119-t1x9gknd 3325 6 use use NN cord-010119-t1x9gknd 3325 7 with with IN cord-010119-t1x9gknd 3325 8 patient patient JJ cord-010119-t1x9gknd 3325 9 HPC hpc NN cord-010119-t1x9gknd 3325 10 products product NNS cord-010119-t1x9gknd 3325 11 and and CC cord-010119-t1x9gknd 3325 12 engraftment engraftment NN cord-010119-t1x9gknd 3325 13 kinetics kinetics NNP cord-010119-t1x9gknd 3325 14 will will MD cord-010119-t1x9gknd 3325 15 be be VB cord-010119-t1x9gknd 3325 16 tracked track VBN cord-010119-t1x9gknd 3325 17 in in IN cord-010119-t1x9gknd 3325 18 a a DT cord-010119-t1x9gknd 3325 19 postimplementation postimplementation NN cord-010119-t1x9gknd 3325 20 study study NN cord-010119-t1x9gknd 3325 21 . . . cord-010119-t1x9gknd 3326 1 Validating validate VBG cord-010119-t1x9gknd 3326 2 78A 78a CD cord-010119-t1x9gknd 3326 3 TRANSFUSION transfusion NN cord-010119-t1x9gknd 3326 4 clinical clinical JJ cord-010119-t1x9gknd 3326 5 assessment assessment NN cord-010119-t1x9gknd 3326 6 . . . cord-010119-t1x9gknd 3327 1 In in IN cord-010119-t1x9gknd 3327 2 the the DT cord-010119-t1x9gknd 3327 3 first first JJ cord-010119-t1x9gknd 3327 4 phase phase NN cord-010119-t1x9gknd 3327 5 , , , cord-010119-t1x9gknd 3327 6 2 2 CD cord-010119-t1x9gknd 3327 7 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 3327 8 PBSC PBSC NNP cord-010119-t1x9gknd 3327 9 products product NNS cord-010119-t1x9gknd 3327 10 were be VBD cord-010119-t1x9gknd 3327 11 tested test VBN cord-010119-t1x9gknd 3327 12 . . . cord-010119-t1x9gknd 3328 1 Two two CD cord-010119-t1x9gknd 3328 2 aliquots aliquot NNS cord-010119-t1x9gknd 3328 3 were be VBD cord-010119-t1x9gknd 3328 4 thawed thaw VBN cord-010119-t1x9gknd 3328 5 simultaneously simultaneously RB cord-010119-t1x9gknd 3328 6 for for IN cord-010119-t1x9gknd 3328 7 each each DT cord-010119-t1x9gknd 3328 8 product product NN cord-010119-t1x9gknd 3328 9 : : : cord-010119-t1x9gknd 3328 10 One one CD cord-010119-t1x9gknd 3328 11 was be VBD cord-010119-t1x9gknd 3328 12 passed pass VBN cord-010119-t1x9gknd 3328 13 through through IN cord-010119-t1x9gknd 3328 14 a a DT cord-010119-t1x9gknd 3328 15 pre pre JJ cord-010119-t1x9gknd 3328 16 - - JJ cord-010119-t1x9gknd 3328 17 set set JJ cord-010119-t1x9gknd 3328 18 infusion infusion NN cord-010119-t1x9gknd 3328 19 pump pump NN cord-010119-t1x9gknd 3328 20 and and CC cord-010119-t1x9gknd 3329 1 a a DT cord-010119-t1x9gknd 3329 2 second second JJ cord-010119-t1x9gknd 3329 3 control control NN cord-010119-t1x9gknd 3329 4 aliquot aliquot NN cord-010119-t1x9gknd 3329 5 was be VBD cord-010119-t1x9gknd 3329 6 drained drain VBN cord-010119-t1x9gknd 3329 7 by by IN cord-010119-t1x9gknd 3329 8 gravity gravity NN cord-010119-t1x9gknd 3329 9 . . . cord-010119-t1x9gknd 3330 1 Each each DT cord-010119-t1x9gknd 3330 2 aliquot aliquot NN cord-010119-t1x9gknd 3330 3 was be VBD cord-010119-t1x9gknd 3330 4 tested test VBN cord-010119-t1x9gknd 3330 5 for for IN cord-010119-t1x9gknd 3330 6 baseline baseline JJ cord-010119-t1x9gknd 3330 7 total total JJ cord-010119-t1x9gknd 3330 8 nucleated nucleated JJ cord-010119-t1x9gknd 3330 9 cell cell NN cord-010119-t1x9gknd 3330 10 ( ( -LRB- cord-010119-t1x9gknd 3330 11 TNC TNC NNP cord-010119-t1x9gknd 3330 12 ) ) -RRB- cord-010119-t1x9gknd 3330 13 count count NN cord-010119-t1x9gknd 3330 14 and and CC cord-010119-t1x9gknd 3330 15 viability viability NN cord-010119-t1x9gknd 3330 16 , , , cord-010119-t1x9gknd 3330 17 and and CC cord-010119-t1x9gknd 3330 18 for for IN cord-010119-t1x9gknd 3330 19 final final JJ cord-010119-t1x9gknd 3330 20 TNC TNC NNP cord-010119-t1x9gknd 3330 21 recovery recovery NN cord-010119-t1x9gknd 3330 22 , , , cord-010119-t1x9gknd 3330 23 Trypan Trypan NNP cord-010119-t1x9gknd 3330 24 Blue Blue NNP cord-010119-t1x9gknd 3330 25 ( ( -LRB- cord-010119-t1x9gknd 3330 26 TB TB NNP cord-010119-t1x9gknd 3330 27 ) ) -RRB- cord-010119-t1x9gknd 3330 28 viability viability NN cord-010119-t1x9gknd 3330 29 , , , cord-010119-t1x9gknd 3330 30 CD34 CD34 NNP cord-010119-t1x9gknd 3330 31 7-AAD 7-aad CD cord-010119-t1x9gknd 3330 32 viability viability NN cord-010119-t1x9gknd 3330 33 , , , cord-010119-t1x9gknd 3330 34 and and CC cord-010119-t1x9gknd 3330 35 potency potency NN cord-010119-t1x9gknd 3330 36 ( ( -LRB- cord-010119-t1x9gknd 3330 37 CFU CFU NNP cord-010119-t1x9gknd 3330 38 ) ) -RRB- cord-010119-t1x9gknd 3330 39 . . . cord-010119-t1x9gknd 3331 1 The the DT cord-010119-t1x9gknd 3331 2 effect effect NN cord-010119-t1x9gknd 3331 3 of of IN cord-010119-t1x9gknd 3331 4 longterm longterm JJ cord-010119-t1x9gknd 3331 5 exposure exposure NN cord-010119-t1x9gknd 3331 6 to to IN cord-010119-t1x9gknd 3331 7 DMSO DMSO NNP cord-010119-t1x9gknd 3331 8 was be VBD cord-010119-t1x9gknd 3331 9 assessed assess VBN cord-010119-t1x9gknd 3331 10 by by IN cord-010119-t1x9gknd 3331 11 visually visually RB cord-010119-t1x9gknd 3331 12 inspecting inspect VBG cord-010119-t1x9gknd 3331 13 the the DT cord-010119-t1x9gknd 3331 14 product product NN cord-010119-t1x9gknd 3331 15 for for IN cord-010119-t1x9gknd 3331 16 aggregates aggregate NNS cord-010119-t1x9gknd 3331 17 and and CC cord-010119-t1x9gknd 3331 18 measuring measure VBG cord-010119-t1x9gknd 3331 19 viability viability NN cord-010119-t1x9gknd 3331 20 up up IN cord-010119-t1x9gknd 3331 21 to to TO cord-010119-t1x9gknd 3331 22 3 3 CD cord-010119-t1x9gknd 3331 23 hours hour NNS cord-010119-t1x9gknd 3331 24 post post NN cord-010119-t1x9gknd 3331 25 thaw thaw NN cord-010119-t1x9gknd 3331 26 . . . cord-010119-t1x9gknd 3332 1 The the DT cord-010119-t1x9gknd 3332 2 second second JJ cord-010119-t1x9gknd 3332 3 in in IN cord-010119-t1x9gknd 3332 4 vivo vivo NN cord-010119-t1x9gknd 3332 5 phase phase NN cord-010119-t1x9gknd 3332 6 included include VBD cord-010119-t1x9gknd 3332 7 use use NN cord-010119-t1x9gknd 3332 8 of of IN cord-010119-t1x9gknd 3332 9 an an DT cord-010119-t1x9gknd 3332 10 infusion infusion NN cord-010119-t1x9gknd 3332 11 pump pump NN cord-010119-t1x9gknd 3332 12 for for IN cord-010119-t1x9gknd 3332 13 10 10 CD cord-010119-t1x9gknd 3332 14 consecutive consecutive JJ cord-010119-t1x9gknd 3332 15 autologous autologous JJ cord-010119-t1x9gknd 3332 16 patients patient NNS cord-010119-t1x9gknd 3332 17 , , , cord-010119-t1x9gknd 3332 18 with with IN cord-010119-t1x9gknd 3332 19 comparison comparison NN cord-010119-t1x9gknd 3332 20 of of IN cord-010119-t1x9gknd 3332 21 infusion infusion NN cord-010119-t1x9gknd 3332 22 and and CC cord-010119-t1x9gknd 3332 23 transplant transplant NN cord-010119-t1x9gknd 3332 24 outcomes outcome NNS cord-010119-t1x9gknd 3332 25 to to IN cord-010119-t1x9gknd 3332 26 18 18 CD cord-010119-t1x9gknd 3332 27 previous previous JJ cord-010119-t1x9gknd 3332 28 infusions infusion NNS cord-010119-t1x9gknd 3332 29 by by IN cord-010119-t1x9gknd 3332 30 gravity gravity NN cord-010119-t1x9gknd 3332 31 drip drip NN cord-010119-t1x9gknd 3332 32 . . . cord-010119-t1x9gknd 3333 1 Comparison comparison NN cord-010119-t1x9gknd 3333 2 variables variable NNS cord-010119-t1x9gknd 3333 3 included include VBD cord-010119-t1x9gknd 3333 4 infusion infusion NN cord-010119-t1x9gknd 3333 5 rate rate NN cord-010119-t1x9gknd 3333 6 , , , cord-010119-t1x9gknd 3333 7 adverse adverse JJ cord-010119-t1x9gknd 3333 8 events event NNS cord-010119-t1x9gknd 3333 9 ( ( -LRB- cord-010119-t1x9gknd 3333 10 AE AE NNP cord-010119-t1x9gknd 3333 11 ) ) -RRB- cord-010119-t1x9gknd 3333 12 , , , cord-010119-t1x9gknd 3333 13 and and CC cord-010119-t1x9gknd 3333 14 engraftment engraftment NNP cord-010119-t1x9gknd 3333 15 time time NN cord-010119-t1x9gknd 3333 16 . . . cord-010119-t1x9gknd 3334 1 Results result NNS cord-010119-t1x9gknd 3335 1 /Finding /finde VBG cord-010119-t1x9gknd 3335 2 : : : cord-010119-t1x9gknd 3335 3 No no DT cord-010119-t1x9gknd 3335 4 significant significant JJ cord-010119-t1x9gknd 3335 5 differences difference NNS cord-010119-t1x9gknd 3335 6 were be VBD cord-010119-t1x9gknd 3335 7 observed observe VBN cord-010119-t1x9gknd 3335 8 between between IN cord-010119-t1x9gknd 3335 9 infusion infusion NN cord-010119-t1x9gknd 3335 10 pump pump NN cord-010119-t1x9gknd 3335 11 and and CC cord-010119-t1x9gknd 3335 12 drip drip VB cord-010119-t1x9gknd 3335 13 for for IN cord-010119-t1x9gknd 3335 14 the the DT cord-010119-t1x9gknd 3335 15 2 2 CD cord-010119-t1x9gknd 3335 16 products product NNS cord-010119-t1x9gknd 3335 17 tested test VBN cord-010119-t1x9gknd 3335 18 in in IN cord-010119-t1x9gknd 3335 19 vitro vitro FW cord-010119-t1x9gknd 3335 20 , , , cord-010119-t1x9gknd 3335 21 including include VBG cord-010119-t1x9gknd 3335 22 TNC TNC NNP cord-010119-t1x9gknd 3335 23 recovery recovery NN cord-010119-t1x9gknd 3335 24 , , , cord-010119-t1x9gknd 3335 25 cell cell NN cord-010119-t1x9gknd 3335 26 viabilities viability NNS cord-010119-t1x9gknd 3335 27 , , , cord-010119-t1x9gknd 3335 28 and and CC cord-010119-t1x9gknd 3335 29 potency potency NN cord-010119-t1x9gknd 3335 30 . . . cord-010119-t1x9gknd 3336 1 For for IN cord-010119-t1x9gknd 3336 2 both both DT cord-010119-t1x9gknd 3336 3 methods method NNS cord-010119-t1x9gknd 3336 4 TNC TNC NNP cord-010119-t1x9gknd 3336 5 TB TB NNP cord-010119-t1x9gknd 3336 6 viability viability NN cord-010119-t1x9gknd 3336 7 decreased decrease VBD cord-010119-t1x9gknd 3336 8 by by IN cord-010119-t1x9gknd 3336 9 more more JJR cord-010119-t1x9gknd 3336 10 than than IN cord-010119-t1x9gknd 3336 11 20 20 CD cord-010119-t1x9gknd 3336 12 % % NN cord-010119-t1x9gknd 3336 13 within within IN cord-010119-t1x9gknd 3336 14 1 1 CD cord-010119-t1x9gknd 3336 15 hour hour NN cord-010119-t1x9gknd 3336 16 , , , cord-010119-t1x9gknd 3336 17 while while IN cord-010119-t1x9gknd 3336 18 CD341 cd341 NN cord-010119-t1x9gknd 3336 19 cell cell NN cord-010119-t1x9gknd 3336 20 viability viability NN cord-010119-t1x9gknd 3336 21 remained remain VBD cord-010119-t1x9gknd 3336 22 stable stable JJ cord-010119-t1x9gknd 3336 23 up up IN cord-010119-t1x9gknd 3336 24 to to TO cord-010119-t1x9gknd 3336 25 3 3 CD cord-010119-t1x9gknd 3336 26 hours hour NNS cord-010119-t1x9gknd 3336 27 post post NN cord-010119-t1x9gknd 3336 28 thaw thaw NN cord-010119-t1x9gknd 3336 29 . . . cord-010119-t1x9gknd 3337 1 Small small JJ cord-010119-t1x9gknd 3337 2 aggregates aggregate NNS cord-010119-t1x9gknd 3337 3 appeared appear VBD cord-010119-t1x9gknd 3337 4 after after IN cord-010119-t1x9gknd 3337 5 1 1 CD cord-010119-t1x9gknd 3337 6 hour hour NN cord-010119-t1x9gknd 3337 7 for for IN cord-010119-t1x9gknd 3337 8 both both DT cord-010119-t1x9gknd 3337 9 methods method NNS cord-010119-t1x9gknd 3337 10 and and CC cord-010119-t1x9gknd 3337 11 increased increase VBD cord-010119-t1x9gknd 3337 12 by by IN cord-010119-t1x9gknd 3337 13 a a DT cord-010119-t1x9gknd 3337 14 similar similar JJ cord-010119-t1x9gknd 3337 15 rate rate NN cord-010119-t1x9gknd 3337 16 over over IN cord-010119-t1x9gknd 3337 17 time time NN cord-010119-t1x9gknd 3337 18 . . . cord-010119-t1x9gknd 3338 1 Comparison comparison NN cord-010119-t1x9gknd 3338 2 of of IN cord-010119-t1x9gknd 3338 3 infusion infusion NN cord-010119-t1x9gknd 3338 4 and and CC cord-010119-t1x9gknd 3338 5 transplant transplant NN cord-010119-t1x9gknd 3338 6 outcomes outcome NNS cord-010119-t1x9gknd 3338 7 between between IN cord-010119-t1x9gknd 3338 8 drip drip NN cord-010119-t1x9gknd 3338 9 and and CC cord-010119-t1x9gknd 3338 10 infusion infusion NN cord-010119-t1x9gknd 3338 11 pump pump NN cord-010119-t1x9gknd 3338 12 patients patient NNS cord-010119-t1x9gknd 3338 13 showed show VBD cord-010119-t1x9gknd 3338 14 no no DT cord-010119-t1x9gknd 3338 15 significant significant JJ cord-010119-t1x9gknd 3338 16 differences difference NNS cord-010119-t1x9gknd 3338 17 for for IN cord-010119-t1x9gknd 3338 18 all all DT cord-010119-t1x9gknd 3338 19 measured measure VBN cord-010119-t1x9gknd 3338 20 variables variable NNS cord-010119-t1x9gknd 3338 21 . . . cord-010119-t1x9gknd 3339 1 Engraftment Engraftment NNP cord-010119-t1x9gknd 3339 2 time time NN cord-010119-t1x9gknd 3339 3 was be VBD cord-010119-t1x9gknd 3339 4 similar similar JJ cord-010119-t1x9gknd 3339 5 for for IN cord-010119-t1x9gknd 3339 6 both both DT cord-010119-t1x9gknd 3339 7 groups group NNS cord-010119-t1x9gknd 3339 8 . . . cord-010119-t1x9gknd 3340 1 ANC ANC NNP cord-010119-t1x9gknd 3340 2 days day NNS cord-010119-t1x9gknd 3340 3 to to IN cord-010119-t1x9gknd 3340 4 engraftment engraftment NN cord-010119-t1x9gknd 3340 5 for for IN cord-010119-t1x9gknd 3340 6 pump pump NN cord-010119-t1x9gknd 3340 7 and and CC cord-010119-t1x9gknd 3340 8 drip drip NN cord-010119-t1x9gknd 3340 9 were be VBD cord-010119-t1x9gknd 3340 10 10.8 10.8 CD cord-010119-t1x9gknd 3340 11 6 6 CD cord-010119-t1x9gknd 3340 12 1.3 1.3 CD cord-010119-t1x9gknd 3340 13 and and CC cord-010119-t1x9gknd 3340 14 11.6 11.6 CD cord-010119-t1x9gknd 3340 15 6 6 CD cord-010119-t1x9gknd 3340 16 1.0 1.0 CD cord-010119-t1x9gknd 3340 17 , , , cord-010119-t1x9gknd 3340 18 respectively respectively RB cord-010119-t1x9gknd 3340 19 ( ( -LRB- cord-010119-t1x9gknd 3340 20 p p NN cord-010119-t1x9gknd 3340 21 - - HYPH cord-010119-t1x9gknd 3340 22 value50.075 value50.075 NNP cord-010119-t1x9gknd 3340 23 ) ) -RRB- cord-010119-t1x9gknd 3340 24 . . . cord-010119-t1x9gknd 3341 1 Platelet platelet NN cord-010119-t1x9gknd 3341 2 days day NNS cord-010119-t1x9gknd 3341 3 to to IN cord-010119-t1x9gknd 3341 4 engraftment engraftment NN cord-010119-t1x9gknd 3341 5 for for IN cord-010119-t1x9gknd 3341 6 pump pump NN cord-010119-t1x9gknd 3341 7 and and CC cord-010119-t1x9gknd 3341 8 drip drip NN cord-010119-t1x9gknd 3341 9 were be VBD cord-010119-t1x9gknd 3341 10 17.9 17.9 CD cord-010119-t1x9gknd 3341 11 6 6 CD cord-010119-t1x9gknd 3341 12 2.2 2.2 CD cord-010119-t1x9gknd 3341 13 and and CC cord-010119-t1x9gknd 3341 14 20.2 20.2 CD cord-010119-t1x9gknd 3341 15 6 6 CD cord-010119-t1x9gknd 3341 16 5.0 5.0 CD cord-010119-t1x9gknd 3341 17 , , , cord-010119-t1x9gknd 3341 18 respectively respectively RB cord-010119-t1x9gknd 3341 19 ( ( -LRB- cord-010119-t1x9gknd 3341 20 p p NN cord-010119-t1x9gknd 3341 21 - - : cord-010119-t1x9gknd 3341 22 value50.207 value50.207 ADD cord-010119-t1x9gknd 3341 23 ) ) -RRB- cord-010119-t1x9gknd 3341 24 . . . cord-010119-t1x9gknd 3342 1 Infusion infusion NN cord-010119-t1x9gknd 3342 2 rates rate NNS cord-010119-t1x9gknd 3342 3 were be VBD cord-010119-t1x9gknd 3342 4 slightly slightly RB cord-010119-t1x9gknd 3342 5 higher high JJR cord-010119-t1x9gknd 3342 6 for for IN cord-010119-t1x9gknd 3342 7 the the DT cord-010119-t1x9gknd 3342 8 pump pump NN cord-010119-t1x9gknd 3342 9 group group NN cord-010119-t1x9gknd 3342 10 . . . cord-010119-t1x9gknd 3343 1 For for IN cord-010119-t1x9gknd 3343 2 control control NN cord-010119-t1x9gknd 3343 3 patients patient NNS cord-010119-t1x9gknd 3343 4 , , , cord-010119-t1x9gknd 3343 5 2 2 CD cord-010119-t1x9gknd 3343 6 required require VBN cord-010119-t1x9gknd 3343 7 transfer transfer NN cord-010119-t1x9gknd 3343 8 of of IN cord-010119-t1x9gknd 3343 9 products product NNS cord-010119-t1x9gknd 3343 10 to to IN cord-010119-t1x9gknd 3343 11 syringes syrinx NNS cord-010119-t1x9gknd 3343 12 due due JJ cord-010119-t1x9gknd 3343 13 to to IN cord-010119-t1x9gknd 3343 14 slow slow JJ cord-010119-t1x9gknd 3343 15 infusion infusion NN cord-010119-t1x9gknd 3343 16 rate rate NN cord-010119-t1x9gknd 3343 17 and and CC cord-010119-t1x9gknd 3343 18 2 2 CD cord-010119-t1x9gknd 3343 19 others other NNS cord-010119-t1x9gknd 3343 20 experienced experience VBD cord-010119-t1x9gknd 3343 21 allergic allergic JJ cord-010119-t1x9gknd 3343 22 and and CC cord-010119-t1x9gknd 3343 23 hypotension hypotension NN cord-010119-t1x9gknd 3343 24 infusion infusion NN cord-010119-t1x9gknd 3343 25 adverse adverse JJ cord-010119-t1x9gknd 3343 26 events event NNS cord-010119-t1x9gknd 3343 27 . . . cord-010119-t1x9gknd 3344 1 Conclusion conclusion NN cord-010119-t1x9gknd 3344 2 : : : cord-010119-t1x9gknd 3344 3 No no DT cord-010119-t1x9gknd 3344 4 significant significant JJ cord-010119-t1x9gknd 3344 5 in in FW cord-010119-t1x9gknd 3344 6 vitro vitro FW cord-010119-t1x9gknd 3344 7 or or CC cord-010119-t1x9gknd 3344 8 clinical clinical JJ cord-010119-t1x9gknd 3344 9 differences difference NNS cord-010119-t1x9gknd 3345 1 were be VBD cord-010119-t1x9gknd 3345 2 observed observe VBN cord-010119-t1x9gknd 3345 3 between between IN cord-010119-t1x9gknd 3345 4 thawed thawed JJ cord-010119-t1x9gknd 3345 5 PBSCs pbsc NNS cord-010119-t1x9gknd 3345 6 infused infuse VBN cord-010119-t1x9gknd 3345 7 by by IN cord-010119-t1x9gknd 3345 8 gravity gravity NN cord-010119-t1x9gknd 3345 9 or or CC cord-010119-t1x9gknd 3345 10 an an DT cord-010119-t1x9gknd 3345 11 infusion infusion NN cord-010119-t1x9gknd 3345 12 pump pump NN cord-010119-t1x9gknd 3345 13 . . . cord-010119-t1x9gknd 3346 1 These these DT cord-010119-t1x9gknd 3346 2 results result NNS cord-010119-t1x9gknd 3346 3 demonstrate demonstrate VBP cord-010119-t1x9gknd 3346 4 that that IN cord-010119-t1x9gknd 3346 5 the the DT cord-010119-t1x9gknd 3346 6 use use NN cord-010119-t1x9gknd 3346 7 of of IN cord-010119-t1x9gknd 3346 8 a a DT cord-010119-t1x9gknd 3346 9 pump pump NN cord-010119-t1x9gknd 3346 10 for for IN cord-010119-t1x9gknd 3346 11 PBSC PBSC NNP cord-010119-t1x9gknd 3346 12 infusion infusion NN cord-010119-t1x9gknd 3346 13 is be VBZ cord-010119-t1x9gknd 3346 14 safe safe JJ cord-010119-t1x9gknd 3346 15 , , , cord-010119-t1x9gknd 3346 16 provides provide VBZ cord-010119-t1x9gknd 3346 17 consistent consistent JJ cord-010119-t1x9gknd 3346 18 infusion infusion NN cord-010119-t1x9gknd 3346 19 rates rate NNS cord-010119-t1x9gknd 3346 20 , , , cord-010119-t1x9gknd 3346 21 eliminates eliminate VBZ cord-010119-t1x9gknd 3346 22 the the DT cord-010119-t1x9gknd 3346 23 need need NN cord-010119-t1x9gknd 3346 24 to to TO cord-010119-t1x9gknd 3346 25 transfer transfer VB cord-010119-t1x9gknd 3346 26 products product NNS cord-010119-t1x9gknd 3346 27 to to IN cord-010119-t1x9gknd 3346 28 syringes syrinx NNS cord-010119-t1x9gknd 3346 29 , , , cord-010119-t1x9gknd 3346 30 and and CC cord-010119-t1x9gknd 3346 31 results result NNS cord-010119-t1x9gknd 3346 32 in in IN cord-010119-t1x9gknd 3346 33 comparable comparable JJ cord-010119-t1x9gknd 3346 34 engraftment engraftment NN cord-010119-t1x9gknd 3346 35 times time NNS cord-010119-t1x9gknd 3346 36 . . . cord-010119-t1x9gknd 3347 1 Donor donor NN cord-010119-t1x9gknd 3347 2 racial racial JJ cord-010119-t1x9gknd 3347 3 distribution distribution NN cord-010119-t1x9gknd 3347 4 among among IN cord-010119-t1x9gknd 3347 5 the the DT cord-010119-t1x9gknd 3347 6 278 278 CD cord-010119-t1x9gknd 3347 7 ZIKV ZIKV NNP cord-010119-t1x9gknd 3347 8 ineligible ineligible JJ cord-010119-t1x9gknd 3347 9 CBUs cbus NN cord-010119-t1x9gknd 3347 10 was be VBD cord-010119-t1x9gknd 3347 11 : : : cord-010119-t1x9gknd 3347 12 Caucasian caucasian JJ cord-010119-t1x9gknd 3347 13 52 52 CD cord-010119-t1x9gknd 3347 14 % % NN cord-010119-t1x9gknd 3347 15 , , , cord-010119-t1x9gknd 3347 16 Asian asian JJ cord-010119-t1x9gknd 3347 17 9 9 CD cord-010119-t1x9gknd 3347 18 % % NN cord-010119-t1x9gknd 3347 19 , , , cord-010119-t1x9gknd 3347 20 Black Black NNP cord-010119-t1x9gknd 3347 21 / / SYM cord-010119-t1x9gknd 3347 22 AA AA NNP cord-010119-t1x9gknd 3347 23 20 20 CD cord-010119-t1x9gknd 3347 24 % % NN cord-010119-t1x9gknd 3347 25 , , , cord-010119-t1x9gknd 3347 26 and and CC cord-010119-t1x9gknd 3347 27 Multi multi JJ cord-010119-t1x9gknd 3347 28 - - JJ cord-010119-t1x9gknd 3347 29 race race NN cord-010119-t1x9gknd 3347 30 21 21 CD cord-010119-t1x9gknd 3347 31 % % NN cord-010119-t1x9gknd 3347 32 . . . cord-010119-t1x9gknd 3348 1 Racial racial JJ cord-010119-t1x9gknd 3348 2 distribution distribution NN cord-010119-t1x9gknd 3348 3 of of IN cord-010119-t1x9gknd 3348 4 all all DT cord-010119-t1x9gknd 3348 5 clinical clinical JJ cord-010119-t1x9gknd 3348 6 CBU CBU NNP cord-010119-t1x9gknd 3348 7 donors donor NNS cord-010119-t1x9gknd 3348 8 was be VBD cord-010119-t1x9gknd 3348 9 Caucasian caucasian JJ cord-010119-t1x9gknd 3348 10 49 49 CD cord-010119-t1x9gknd 3348 11 % % NN cord-010119-t1x9gknd 3348 12 , , , cord-010119-t1x9gknd 3348 13 Asian asian JJ cord-010119-t1x9gknd 3348 14 15 15 CD cord-010119-t1x9gknd 3348 15 % % NN cord-010119-t1x9gknd 3348 16 , , , cord-010119-t1x9gknd 3348 17 Black Black NNP cord-010119-t1x9gknd 3348 18 / / SYM cord-010119-t1x9gknd 3348 19 AA AA NNP cord-010119-t1x9gknd 3348 20 20 20 CD cord-010119-t1x9gknd 3348 21 % % NN cord-010119-t1x9gknd 3348 22 , , , cord-010119-t1x9gknd 3348 23 and and CC cord-010119-t1x9gknd 3348 24 Multi multi JJ cord-010119-t1x9gknd 3348 25 - - JJ cord-010119-t1x9gknd 3348 26 race race NN cord-010119-t1x9gknd 3348 27 17 17 CD cord-010119-t1x9gknd 3348 28 % % NN cord-010119-t1x9gknd 3348 29 , , , cord-010119-t1x9gknd 3348 30 suggesting suggest VBG cord-010119-t1x9gknd 3348 31 there there EX cord-010119-t1x9gknd 3348 32 is be VBZ cord-010119-t1x9gknd 3348 33 no no DT cord-010119-t1x9gknd 3348 34 race race NN cord-010119-t1x9gknd 3348 35 correlation correlation NN cord-010119-t1x9gknd 3348 36 for for IN cord-010119-t1x9gknd 3348 37 this this DT cord-010119-t1x9gknd 3348 38 risk risk NN cord-010119-t1x9gknd 3348 39 factor factor NN cord-010119-t1x9gknd 3348 40 driven drive VBN cord-010119-t1x9gknd 3348 41 by by IN cord-010119-t1x9gknd 3348 42 cultural cultural JJ cord-010119-t1x9gknd 3348 43 habits habit NNS cord-010119-t1x9gknd 3348 44 such such JJ cord-010119-t1x9gknd 3348 45 as as IN cord-010119-t1x9gknd 3348 46 family family NN cord-010119-t1x9gknd 3348 47 travel travel NN cord-010119-t1x9gknd 3348 48 . . . cord-010119-t1x9gknd 3349 1 There there EX cord-010119-t1x9gknd 3349 2 were be VBD cord-010119-t1x9gknd 3349 3 no no DT cord-010119-t1x9gknd 3349 4 cases case NNS cord-010119-t1x9gknd 3349 5 in in IN cord-010119-t1x9gknd 3349 6 which which WDT cord-010119-t1x9gknd 3349 7 onlythe onlythe NNP cord-010119-t1x9gknd 3349 8 sexual sexual JJ cord-010119-t1x9gknd 3349 9 partner partner NN cord-010119-t1x9gknd 3349 10 's 's POS cord-010119-t1x9gknd 3349 11 potential potential JJ cord-010119-t1x9gknd 3349 12 exposure exposure NN cord-010119-t1x9gknd 3349 13 determined determine VBD cord-010119-t1x9gknd 3349 14 donor donor NN cord-010119-t1x9gknd 3349 15 's 's POS cord-010119-t1x9gknd 3349 16 ineligibility ineligibility NN cord-010119-t1x9gknd 3349 17 . . . cord-010119-t1x9gknd 3350 1 Conclusion conclusion NN cord-010119-t1x9gknd 3350 2 : : : cord-010119-t1x9gknd 3351 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3351 2 study study NN cord-010119-t1x9gknd 3351 3 indicates indicate VBZ cord-010119-t1x9gknd 3351 4 that that IN cord-010119-t1x9gknd 3351 5 currently currently RB cord-010119-t1x9gknd 3351 6 the the DT cord-010119-t1x9gknd 3351 7 leading lead VBG cord-010119-t1x9gknd 3351 8 risk risk NN cord-010119-t1x9gknd 3351 9 factor factor NN cord-010119-t1x9gknd 3351 10 for for IN cord-010119-t1x9gknd 3351 11 ineligible ineligible JJ cord-010119-t1x9gknd 3351 12 CB CB NNP cord-010119-t1x9gknd 3351 13 donors donor NNS cord-010119-t1x9gknd 3351 14 is be VBZ cord-010119-t1x9gknd 3351 15 potential potential JJ cord-010119-t1x9gknd 3351 16 exposure exposure NN cord-010119-t1x9gknd 3351 17 to to IN cord-010119-t1x9gknd 3351 18 ZIKV ZIKV NNP cord-010119-t1x9gknd 3351 19 : : : cord-010119-t1x9gknd 3351 20 78 78 CD cord-010119-t1x9gknd 3351 21 % % NN cord-010119-t1x9gknd 3351 22 of of IN cord-010119-t1x9gknd 3351 23 all all DT cord-010119-t1x9gknd 3351 24 ineligible ineligible JJ cord-010119-t1x9gknd 3351 25 CBUs cbu NNS cord-010119-t1x9gknd 3351 26 and and CC cord-010119-t1x9gknd 3351 27 21 21 CD cord-010119-t1x9gknd 3351 28 % % NN cord-010119-t1x9gknd 3351 29 of of IN cord-010119-t1x9gknd 3351 30 all all DT cord-010119-t1x9gknd 3351 31 banked bank VBN cord-010119-t1x9gknd 3351 32 CBUs cbus NN cord-010119-t1x9gknd 3351 33 in in IN cord-010119-t1x9gknd 3351 34 the the DT cord-010119-t1x9gknd 3351 35 study study NN cord-010119-t1x9gknd 3351 36 period period NN cord-010119-t1x9gknd 3351 37 . . . cord-010119-t1x9gknd 3352 1 We -PRON- PRP cord-010119-t1x9gknd 3352 2 anticipate anticipate VBP cord-010119-t1x9gknd 3352 3 the the DT cord-010119-t1x9gknd 3352 4 number number NN cord-010119-t1x9gknd 3352 5 of of IN cord-010119-t1x9gknd 3352 6 cases case NNS cord-010119-t1x9gknd 3352 7 to to TO cord-010119-t1x9gknd 3352 8 decrease decrease VB cord-010119-t1x9gknd 3352 9 following follow VBG cord-010119-t1x9gknd 3352 10 maternal maternal JJ cord-010119-t1x9gknd 3352 11 education education NN cord-010119-t1x9gknd 3352 12 and and CC cord-010119-t1x9gknd 3352 13 travel travel NN cord-010119-t1x9gknd 3352 14 warnings warning NNS cord-010119-t1x9gknd 3352 15 . . . cord-010119-t1x9gknd 3353 1 Recognizing recognize VBG cord-010119-t1x9gknd 3353 2 the the DT cord-010119-t1x9gknd 3353 3 importance importance NN cord-010119-t1x9gknd 3353 4 of of IN cord-010119-t1x9gknd 3353 5 ZIKV ZIKV NNP cord-010119-t1x9gknd 3353 6 in in IN cord-010119-t1x9gknd 3353 7 public public JJ cord-010119-t1x9gknd 3353 8 health health NN cord-010119-t1x9gknd 3353 9 , , , cord-010119-t1x9gknd 3353 10 and and CC cord-010119-t1x9gknd 3353 11 its -PRON- PRP$ cord-010119-t1x9gknd 3353 12 potential potential JJ cord-010119-t1x9gknd 3353 13 transmission transmission NN cord-010119-t1x9gknd 3353 14 via via IN cord-010119-t1x9gknd 3353 15 HCT HCT NNP cord-010119-t1x9gknd 3353 16 / / SYM cord-010119-t1x9gknd 3353 17 P p NN cord-010119-t1x9gknd 3353 18 products product NNS cord-010119-t1x9gknd 3353 19 , , , cord-010119-t1x9gknd 3353 20 an an DT cord-010119-t1x9gknd 3353 21 FDA FDA NNP cord-010119-t1x9gknd 3353 22 approved approve VBN cord-010119-t1x9gknd 3353 23 screening screening NN cord-010119-t1x9gknd 3353 24 test test NN cord-010119-t1x9gknd 3353 25 for for IN cord-010119-t1x9gknd 3353 26 HCT/ HCT/ NNP cord-010119-t1x9gknd 3353 27 P P NNP cord-010119-t1x9gknd 3353 28 donors donor NNS cord-010119-t1x9gknd 3353 29 becomes become VBZ cord-010119-t1x9gknd 3353 30 a a DT cord-010119-t1x9gknd 3353 31 timely timely JJ cord-010119-t1x9gknd 3353 32 necessity necessity NN cord-010119-t1x9gknd 3353 33 . . . cord-010119-t1x9gknd 3354 1 Acknowledgments acknowledgment NNS cord-010119-t1x9gknd 3354 2 : : : cord-010119-t1x9gknd 3354 3 Funded fund VBN cord-010119-t1x9gknd 3354 4 by by IN cord-010119-t1x9gknd 3354 5 Zimmer Zimmer NNP cord-010119-t1x9gknd 3354 6 Biomet Biomet NNP cord-010119-t1x9gknd 3354 7 , , , cord-010119-t1x9gknd 3354 8 a a DT cord-010119-t1x9gknd 3354 9 Zimmer Zimmer NNP cord-010119-t1x9gknd 3354 10 Biomet Biomet NNP cord-010119-t1x9gknd 3354 11 company company NN cord-010119-t1x9gknd 3354 12 , , , cord-010119-t1x9gknd 3354 13 IBGRL IBGRL NNP cord-010119-t1x9gknd 3354 14 Red Red NNP cord-010119-t1x9gknd 3354 15 Cell Cell NNP cord-010119-t1x9gknd 3354 16 Reference Reference NNP cord-010119-t1x9gknd 3354 17 and and CC cord-010119-t1x9gknd 3354 18 NHSBT NHSBT NNP cord-010119-t1x9gknd 3354 19 Reagents Reagents NNPS cord-010119-t1x9gknd 3354 20 Background Background NNP cord-010119-t1x9gknd 3354 21 / / SYM cord-010119-t1x9gknd 3354 22 Case case NN cord-010119-t1x9gknd 3355 1 Studies study NNS cord-010119-t1x9gknd 3355 2 : : : cord-010119-t1x9gknd 3355 3 During during IN cord-010119-t1x9gknd 3355 4 storage storage NN cord-010119-t1x9gknd 3355 5 , , , cord-010119-t1x9gknd 3355 6 red red JJ cord-010119-t1x9gknd 3355 7 blood blood NN cord-010119-t1x9gknd 3355 8 cells cell NNS cord-010119-t1x9gknd 3355 9 ( ( -LRB- cord-010119-t1x9gknd 3355 10 RBCs rbc NNS cord-010119-t1x9gknd 3355 11 ) ) -RRB- cord-010119-t1x9gknd 3355 12 become become VBP cord-010119-t1x9gknd 3355 13 less less RBR cord-010119-t1x9gknd 3355 14 deformable deformable JJ cord-010119-t1x9gknd 3355 15 , , , cord-010119-t1x9gknd 3355 16 deplete deplete VB cord-010119-t1x9gknd 3355 17 2,3-diphosphoglycerate 2,3-diphosphoglycerate CD cord-010119-t1x9gknd 3355 18 ( ( -LRB- cord-010119-t1x9gknd 3355 19 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3355 20 ) ) -RRB- cord-010119-t1x9gknd 3355 21 and and CC cord-010119-t1x9gknd 3355 22 adenosine adenosine NN cord-010119-t1x9gknd 3355 23 triphosphate triphosphate NN cord-010119-t1x9gknd 3355 24 ( ( -LRB- cord-010119-t1x9gknd 3355 25 ATP ATP NNP cord-010119-t1x9gknd 3355 26 ) ) -RRB- cord-010119-t1x9gknd 3355 27 , , , cord-010119-t1x9gknd 3355 28 release release VB cord-010119-t1x9gknd 3355 29 pro pro JJ cord-010119-t1x9gknd 3355 30 - - JJ cord-010119-t1x9gknd 3355 31 coagulation coagulation JJ cord-010119-t1x9gknd 3355 32 phospholipids phospholipid NNS cord-010119-t1x9gknd 3355 33 , , , cord-010119-t1x9gknd 3355 34 accumulate accumulate VBP cord-010119-t1x9gknd 3355 35 pro pro JJ cord-010119-t1x9gknd 3355 36 - - JJ cord-010119-t1x9gknd 3355 37 inflammatory inflammatory JJ cord-010119-t1x9gknd 3355 38 molecules molecule NNS cord-010119-t1x9gknd 3355 39 , , , cord-010119-t1x9gknd 3355 40 free free JJ cord-010119-t1x9gknd 3355 41 iron iron NN cord-010119-t1x9gknd 3355 42 and and CC cord-010119-t1x9gknd 3355 43 haemoglobin haemoglobin NN cord-010119-t1x9gknd 3355 44 and and CC cord-010119-t1x9gknd 3355 45 increase increase VB cord-010119-t1x9gknd 3355 46 their -PRON- PRP$ cord-010119-t1x9gknd 3355 47 potential potential NN cord-010119-t1x9gknd 3355 48 for for IN cord-010119-t1x9gknd 3355 49 adhesion adhesion NN cord-010119-t1x9gknd 3355 50 to to IN cord-010119-t1x9gknd 3355 51 a a DT cord-010119-t1x9gknd 3355 52 recipient recipient NN cord-010119-t1x9gknd 3355 53 's 's POS cord-010119-t1x9gknd 3355 54 vascular vascular JJ cord-010119-t1x9gknd 3355 55 endothelium endothelium NN cord-010119-t1x9gknd 3355 56 . . . cord-010119-t1x9gknd 3356 1 Longer long RBR cord-010119-t1x9gknd 3356 2 RBC RBC NNP cord-010119-t1x9gknd 3356 3 storage storage NN cord-010119-t1x9gknd 3356 4 may may MD cord-010119-t1x9gknd 3356 5 impair impair VB cord-010119-t1x9gknd 3356 6 transfusion transfusion NN cord-010119-t1x9gknd 3356 7 outcome outcome NN cord-010119-t1x9gknd 3356 8 due due JJ cord-010119-t1x9gknd 3356 9 to to IN cord-010119-t1x9gknd 3356 10 impaired impaired JJ cord-010119-t1x9gknd 3356 11 oxygen oxygen NN cord-010119-t1x9gknd 3356 12 delivery delivery NN cord-010119-t1x9gknd 3356 13 , , , cord-010119-t1x9gknd 3356 14 promotion promotion NN cord-010119-t1x9gknd 3356 15 of of IN cord-010119-t1x9gknd 3356 16 oxidative oxidative JJ cord-010119-t1x9gknd 3356 17 stress stress NN cord-010119-t1x9gknd 3356 18 , , , cord-010119-t1x9gknd 3356 19 increased increase VBN cord-010119-t1x9gknd 3356 20 pro pro JJ cord-010119-t1x9gknd 3356 21 - - JJ cord-010119-t1x9gknd 3356 22 inflammatory inflammatory JJ cord-010119-t1x9gknd 3356 23 state state NN cord-010119-t1x9gknd 3356 24 and and CC cord-010119-t1x9gknd 3356 25 coagulation coagulation NN cord-010119-t1x9gknd 3356 26 . . . cord-010119-t1x9gknd 3357 1 A a DT cord-010119-t1x9gknd 3357 2 sterile sterile JJ cord-010119-t1x9gknd 3357 3 , , , cord-010119-t1x9gknd 3357 4 non non JJ cord-010119-t1x9gknd 3357 5 - - JJ cord-010119-t1x9gknd 3357 6 pyrogenic pyrogenic JJ cord-010119-t1x9gknd 3357 7 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3357 8 solution solution NN cord-010119-t1x9gknd 3357 9 , , , cord-010119-t1x9gknd 3357 10 containing contain VBG cord-010119-t1x9gknd 3357 11 pyruvate pyruvate NN cord-010119-t1x9gknd 3357 12 , , , cord-010119-t1x9gknd 3357 13 inosine inosine NN cord-010119-t1x9gknd 3357 14 , , , cord-010119-t1x9gknd 3357 15 phosphate phosphate NN cord-010119-t1x9gknd 3357 16 , , , cord-010119-t1x9gknd 3357 17 and and CC cord-010119-t1x9gknd 3357 18 adenine adenine NN cord-010119-t1x9gknd 3357 19 ( ( -LRB- cord-010119-t1x9gknd 3357 20 Citra Citra NNP cord-010119-t1x9gknd 3357 21 Labs Labs NNP cord-010119-t1x9gknd 3357 22 , , , cord-010119-t1x9gknd 3357 23 LLC LLC NNP cord-010119-t1x9gknd 3357 24 , , , cord-010119-t1x9gknd 3357 25 Braintree Braintree NNP cord-010119-t1x9gknd 3357 26 , , , cord-010119-t1x9gknd 3357 27 MA MA NNP cord-010119-t1x9gknd 3357 28 ) ) -RRB- cord-010119-t1x9gknd 3357 29 , , , cord-010119-t1x9gknd 3357 30 is be VBZ cord-010119-t1x9gknd 3357 31 approved approve VBN cord-010119-t1x9gknd 3357 32 by by IN cord-010119-t1x9gknd 3357 33 the the DT cord-010119-t1x9gknd 3357 34 U.S. U.S. NNP cord-010119-t1x9gknd 3357 35 Food Food NNP cord-010119-t1x9gknd 3357 36 and and CC cord-010119-t1x9gknd 3357 37 Drug Drug NNP cord-010119-t1x9gknd 3357 38 Administration Administration NNP cord-010119-t1x9gknd 3357 39 for for IN cord-010119-t1x9gknd 3357 40 the the DT cord-010119-t1x9gknd 3357 41 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3357 42 of of IN cord-010119-t1x9gknd 3357 43 stored store VBN cord-010119-t1x9gknd 3357 44 RBCs rbc NNS cord-010119-t1x9gknd 3357 45 . . . cord-010119-t1x9gknd 3358 1 The the DT cord-010119-t1x9gknd 3358 2 solution solution NN cord-010119-t1x9gknd 3358 3 acts act VBZ cord-010119-t1x9gknd 3358 4 by by IN cord-010119-t1x9gknd 3358 5 restoring restore VBG cord-010119-t1x9gknd 3358 6 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3358 7 and and CC cord-010119-t1x9gknd 3358 8 ATP ATP NNP cord-010119-t1x9gknd 3358 9 in in IN cord-010119-t1x9gknd 3358 10 stored store VBN cord-010119-t1x9gknd 3358 11 RBCs rbc NNS cord-010119-t1x9gknd 3358 12 to to IN cord-010119-t1x9gknd 3358 13 levels level NNS cord-010119-t1x9gknd 3358 14 equivalent equivalent JJ cord-010119-t1x9gknd 3358 15 to to IN cord-010119-t1x9gknd 3358 16 those those DT cord-010119-t1x9gknd 3358 17 in in IN cord-010119-t1x9gknd 3358 18 the the DT cord-010119-t1x9gknd 3358 19 circulation circulation NN cord-010119-t1x9gknd 3358 20 . . . cord-010119-t1x9gknd 3359 1 The the DT cord-010119-t1x9gknd 3359 2 aim aim NN cord-010119-t1x9gknd 3359 3 of of IN cord-010119-t1x9gknd 3359 4 the the DT cord-010119-t1x9gknd 3359 5 study study NN cord-010119-t1x9gknd 3359 6 was be VBD cord-010119-t1x9gknd 3359 7 to to TO cord-010119-t1x9gknd 3359 8 investigate investigate VB cord-010119-t1x9gknd 3359 9 the the DT cord-010119-t1x9gknd 3359 10 effect effect NN cord-010119-t1x9gknd 3359 11 treatment treatment NN cord-010119-t1x9gknd 3359 12 with with IN cord-010119-t1x9gknd 3359 13 this this DT cord-010119-t1x9gknd 3359 14 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3359 15 solution solution NN cord-010119-t1x9gknd 3359 16 had have VBD cord-010119-t1x9gknd 3359 17 on on IN cord-010119-t1x9gknd 3359 18 the the DT cord-010119-t1x9gknd 3359 19 crossmatch crossmatch NN cord-010119-t1x9gknd 3359 20 reaction reaction NN cord-010119-t1x9gknd 3359 21 profile profile NN cord-010119-t1x9gknd 3359 22 and and CC cord-010119-t1x9gknd 3359 23 phenotypic phenotypic JJ cord-010119-t1x9gknd 3359 24 state state NN cord-010119-t1x9gknd 3359 25 of of IN cord-010119-t1x9gknd 3359 26 stored store VBN cord-010119-t1x9gknd 3359 27 RBCs rbc NNS cord-010119-t1x9gknd 3359 28 . . . cord-010119-t1x9gknd 3360 1 Study Study NNP cord-010119-t1x9gknd 3360 2 Design Design NNP cord-010119-t1x9gknd 3360 3 / / SYM cord-010119-t1x9gknd 3360 4 Method method NN cord-010119-t1x9gknd 3360 5 : : : cord-010119-t1x9gknd 3361 1 A a DT cord-010119-t1x9gknd 3361 2 10 10 CD cord-010119-t1x9gknd 3361 3 mL ml NN cord-010119-t1x9gknd 3361 4 aliquot aliquot NN cord-010119-t1x9gknd 3361 5 was be VBD cord-010119-t1x9gknd 3361 6 removed remove VBN cord-010119-t1x9gknd 3361 7 from from IN cord-010119-t1x9gknd 3361 8 ABO ABO NNP cord-010119-t1x9gknd 3361 9 / / SYM cord-010119-t1x9gknd 3361 10 Rh Rh NNP cord-010119-t1x9gknd 3361 11 grouped group VBD cord-010119-t1x9gknd 3361 12 , , , cord-010119-t1x9gknd 3361 13 leucocyte leucocyte NNP cord-010119-t1x9gknd 3361 14 depleted deplete VBD cord-010119-t1x9gknd 3361 15 RBC RBC NNP cord-010119-t1x9gknd 3361 16 units unit NNS cord-010119-t1x9gknd 3361 17 ( ( -LRB- cord-010119-t1x9gknd 3361 18 n n NN cord-010119-t1x9gknd 3361 19 5 5 CD cord-010119-t1x9gknd 3361 20 20 20 CD cord-010119-t1x9gknd 3361 21 ) ) -RRB- cord-010119-t1x9gknd 3361 22 , , , cord-010119-t1x9gknd 3361 23 which which WDT cord-010119-t1x9gknd 3361 24 were be VBD cord-010119-t1x9gknd 3361 25 stored store VBN cord-010119-t1x9gknd 3361 26 in in IN cord-010119-t1x9gknd 3361 27 SAGM SAGM NNP cord-010119-t1x9gknd 3361 28 for for IN cord-010119-t1x9gknd 3361 29 22 22 CD cord-010119-t1x9gknd 3361 30 days day NNS cord-010119-t1x9gknd 3361 31 , , , cord-010119-t1x9gknd 3361 32 to to TO cord-010119-t1x9gknd 3361 33 act act VB cord-010119-t1x9gknd 3361 34 as as IN cord-010119-t1x9gknd 3361 35 untreated untreated JJ cord-010119-t1x9gknd 3361 36 controls control NNS cord-010119-t1x9gknd 3361 37 . . . cord-010119-t1x9gknd 3362 1 The the DT cord-010119-t1x9gknd 3362 2 remainder remainder NN cord-010119-t1x9gknd 3362 3 of of IN cord-010119-t1x9gknd 3362 4 each each DT cord-010119-t1x9gknd 3362 5 unit unit NN cord-010119-t1x9gknd 3362 6 ( ( -LRB- cord-010119-t1x9gknd 3362 7 $ $ $ cord-010119-t1x9gknd 3362 8 270 270 CD cord-010119-t1x9gknd 3362 9 mL mL NNS cord-010119-t1x9gknd 3362 10 ) ) -RRB- cord-010119-t1x9gknd 3362 11 underwent undergo VBD cord-010119-t1x9gknd 3362 12 treatment treatment NN cord-010119-t1x9gknd 3362 13 with with IN cord-010119-t1x9gknd 3362 14 the the DT cord-010119-t1x9gknd 3362 15 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3362 16 solution solution NN cord-010119-t1x9gknd 3362 17 ( ( -LRB- cord-010119-t1x9gknd 3362 18 50mL 50ml CD cord-010119-t1x9gknd 3362 19 , , , cord-010119-t1x9gknd 3362 20 60minutes 60minutes CD cord-010119-t1x9gknd 3362 21 at at IN cord-010119-t1x9gknd 3362 22 37 37 CD cord-010119-t1x9gknd 3362 23 o o NN cord-010119-t1x9gknd 3362 24 C c NN cord-010119-t1x9gknd 3362 25 ) ) -RRB- cord-010119-t1x9gknd 3362 26 , , , cord-010119-t1x9gknd 3362 27 followed follow VBN cord-010119-t1x9gknd 3362 28 by by IN cord-010119-t1x9gknd 3362 29 cell cell NN cord-010119-t1x9gknd 3362 30 washing washing NN cord-010119-t1x9gknd 3362 31 twice twice RB cord-010119-t1x9gknd 3362 32 in in IN cord-010119-t1x9gknd 3362 33 SAGM SAGM NNP cord-010119-t1x9gknd 3362 34 ( ( -LRB- cord-010119-t1x9gknd 3362 35 ' ' `` cord-010119-t1x9gknd 3362 36 manual manual JJ cord-010119-t1x9gknd 3362 37 ' ' '' cord-010119-t1x9gknd 3362 38 centrifuge centrifuge NN cord-010119-t1x9gknd 3362 39 - - HYPH cord-010119-t1x9gknd 3362 40 based base VBN cord-010119-t1x9gknd 3362 41 process process NN cord-010119-t1x9gknd 3362 42 ) ) -RRB- cord-010119-t1x9gknd 3362 43 . . . cord-010119-t1x9gknd 3363 1 To to TO cord-010119-t1x9gknd 3363 2 represent represent VB cord-010119-t1x9gknd 3363 3 current current JJ cord-010119-t1x9gknd 3363 4 transfusion transfusion NN cord-010119-t1x9gknd 3363 5 laboratory laboratory NN cord-010119-t1x9gknd 3363 6 practice practice NN cord-010119-t1x9gknd 3363 7 , , , cord-010119-t1x9gknd 3363 8 units unit NNS cord-010119-t1x9gknd 3363 9 were be VBD cord-010119-t1x9gknd 3363 10 crossmatched crossmatche VBN cord-010119-t1x9gknd 3363 11 against against IN cord-010119-t1x9gknd 3363 12 plasma plasma NN cord-010119-t1x9gknd 3363 13 from from IN cord-010119-t1x9gknd 3363 14 39 39 CD cord-010119-t1x9gknd 3363 15 random random JJ cord-010119-t1x9gknd 3363 16 donors donor NNS cord-010119-t1x9gknd 3363 17 , , , cord-010119-t1x9gknd 3363 18 using use VBG cord-010119-t1x9gknd 3363 19 both both DT cord-010119-t1x9gknd 3363 20 Diamed Diamed NNP cord-010119-t1x9gknd 3363 21 gel gel NN cord-010119-t1x9gknd 3363 22 column column NN cord-010119-t1x9gknd 3363 23 and and CC cord-010119-t1x9gknd 3363 24 glass glass NN cord-010119-t1x9gknd 3363 25 tube tube NN cord-010119-t1x9gknd 3363 26 technique technique NN cord-010119-t1x9gknd 3363 27 . . . cord-010119-t1x9gknd 3364 1 Phenotype phenotype NN cord-010119-t1x9gknd 3364 2 investigation investigation NN cord-010119-t1x9gknd 3364 3 with with IN cord-010119-t1x9gknd 3364 4 commercial commercial JJ cord-010119-t1x9gknd 3364 5 antisera antisera NN cord-010119-t1x9gknd 3364 6 was be VBD cord-010119-t1x9gknd 3364 7 performed perform VBN cord-010119-t1x9gknd 3364 8 to to TO cord-010119-t1x9gknd 3364 9 identify identify VB cord-010119-t1x9gknd 3364 10 the the DT cord-010119-t1x9gknd 3364 11 effect effect NN cord-010119-t1x9gknd 3364 12 the the DT cord-010119-t1x9gknd 3364 13 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3364 14 solution solution NN cord-010119-t1x9gknd 3364 15 treatment treatment NN cord-010119-t1x9gknd 3364 16 exerted exert VBN cord-010119-t1x9gknd 3364 17 on on IN cord-010119-t1x9gknd 3364 18 RBC RBC NNP cord-010119-t1x9gknd 3364 19 surface surface NN cord-010119-t1x9gknd 3364 20 antigens antigen NNS cord-010119-t1x9gknd 3364 21 ( ( -LRB- cord-010119-t1x9gknd 3364 22 A A NNP cord-010119-t1x9gknd 3364 23 , , , cord-010119-t1x9gknd 3364 24 B b NN cord-010119-t1x9gknd 3364 25 , , , cord-010119-t1x9gknd 3364 26 D D NNP cord-010119-t1x9gknd 3364 27 , , , cord-010119-t1x9gknd 3364 28 C C NNP cord-010119-t1x9gknd 3364 29 , , , cord-010119-t1x9gknd 3364 30 c c NNP cord-010119-t1x9gknd 3364 31 , , , cord-010119-t1x9gknd 3364 32 E E NNP cord-010119-t1x9gknd 3364 33 , , , cord-010119-t1x9gknd 3364 34 e e NNP cord-010119-t1x9gknd 3364 35 , , , cord-010119-t1x9gknd 3364 36 K K NNP cord-010119-t1x9gknd 3364 37 , , , cord-010119-t1x9gknd 3364 38 M M NNP cord-010119-t1x9gknd 3364 39 , , , cord-010119-t1x9gknd 3364 40 N N NNP cord-010119-t1x9gknd 3364 41 , , , cord-010119-t1x9gknd 3364 42 S S NNP cord-010119-t1x9gknd 3364 43 , , , cord-010119-t1x9gknd 3364 44 s s NNP cord-010119-t1x9gknd 3364 45 , , , cord-010119-t1x9gknd 3364 46 P P NNP cord-010119-t1x9gknd 3364 47 1 1 CD cord-010119-t1x9gknd 3364 48 , , , cord-010119-t1x9gknd 3364 49 Lu Lu NNP cord-010119-t1x9gknd 3364 50 a a NNP cord-010119-t1x9gknd 3364 51 , , , cord-010119-t1x9gknd 3365 1 k k NNP cord-010119-t1x9gknd 3365 2 , , , cord-010119-t1x9gknd 3365 3 Kp Kp NNP cord-010119-t1x9gknd 3365 4 a a DT cord-010119-t1x9gknd 3365 5 , , , cord-010119-t1x9gknd 3365 6 Kp Kp NNP cord-010119-t1x9gknd 3365 7 b b NNP cord-010119-t1x9gknd 3366 1 , , , cord-010119-t1x9gknd 3366 2 Le Le NNP cord-010119-t1x9gknd 3366 3 a a NNP cord-010119-t1x9gknd 3366 4 , , , cord-010119-t1x9gknd 3366 5 Le Le NNP cord-010119-t1x9gknd 3366 6 b b NNP cord-010119-t1x9gknd 3367 1 , , , cord-010119-t1x9gknd 3367 2 Fy Fy NNP cord-010119-t1x9gknd 3367 3 a a DT cord-010119-t1x9gknd 3367 4 , , , cord-010119-t1x9gknd 3367 5 Fy Fy NNP cord-010119-t1x9gknd 3367 6 b b NNP cord-010119-t1x9gknd 3367 7 , , , cord-010119-t1x9gknd 3368 1 Jk Jk NNP cord-010119-t1x9gknd 3368 2 a a DT cord-010119-t1x9gknd 3368 3 , , , cord-010119-t1x9gknd 3368 4 and and CC cord-010119-t1x9gknd 3368 5 Jk Jk NNP cord-010119-t1x9gknd 3368 6 b b NNP cord-010119-t1x9gknd 3368 7 ) ) -RRB- cord-010119-t1x9gknd 3368 8 , , , cord-010119-t1x9gknd 3368 9 including include VBG cord-010119-t1x9gknd 3368 10 whether whether IN cord-010119-t1x9gknd 3368 11 it -PRON- PRP cord-010119-t1x9gknd 3368 12 exposed expose VBD cord-010119-t1x9gknd 3368 13 crypt crypt NN cord-010119-t1x9gknd 3368 14 antigens antigen NNS cord-010119-t1x9gknd 3368 15 ( ( -LRB- cord-010119-t1x9gknd 3368 16 T T NNP cord-010119-t1x9gknd 3368 17 , , , cord-010119-t1x9gknd 3368 18 Tn Tn NNP cord-010119-t1x9gknd 3368 19 , , , cord-010119-t1x9gknd 3368 20 Tk Tk NNP cord-010119-t1x9gknd 3368 21 * * NFP cord-010119-t1x9gknd 3368 22 , , , cord-010119-t1x9gknd 3368 23 Th Th NNP cord-010119-t1x9gknd 3368 24 , , , cord-010119-t1x9gknd 3368 25 Tx Tx NNP cord-010119-t1x9gknd 3368 26 * * NNP cord-010119-t1x9gknd 3368 27 , , , cord-010119-t1x9gknd 3368 28 and and CC cord-010119-t1x9gknd 3368 29 CAD CAD NNP cord-010119-t1x9gknd 3368 30 ) ) -RRB- cord-010119-t1x9gknd 3368 31 . . . cord-010119-t1x9gknd 3369 1 Crossmatch crossmatch NN cord-010119-t1x9gknd 3369 2 and and CC cord-010119-t1x9gknd 3369 3 phenotype phenotype NN cord-010119-t1x9gknd 3369 4 agglutination agglutination NN cord-010119-t1x9gknd 3369 5 scores score NNS cord-010119-t1x9gknd 3369 6 observed observe VBD cord-010119-t1x9gknd 3369 7 for for IN cord-010119-t1x9gknd 3369 8 the the DT cord-010119-t1x9gknd 3369 9 untreated untreated JJ cord-010119-t1x9gknd 3369 10 and and CC cord-010119-t1x9gknd 3369 11 treated treat VBN cord-010119-t1x9gknd 3369 12 RBCs rbc NNS cord-010119-t1x9gknd 3369 13 were be VBD cord-010119-t1x9gknd 3369 14 then then RB cord-010119-t1x9gknd 3369 15 compared compare VBN cord-010119-t1x9gknd 3369 16 . . . cord-010119-t1x9gknd 3370 1 Results result NNS cord-010119-t1x9gknd 3370 2 / / SYM cord-010119-t1x9gknd 3370 3 Finding finding NN cord-010119-t1x9gknd 3370 4 : : : cord-010119-t1x9gknd 3371 1 Crossmatch crossmatch NN cord-010119-t1x9gknd 3371 2 findings finding NNS cord-010119-t1x9gknd 3371 3 were be VBD cord-010119-t1x9gknd 3371 4 defined define VBN cord-010119-t1x9gknd 3371 5 as as IN cord-010119-t1x9gknd 3371 6 compatible compatible JJ cord-010119-t1x9gknd 3371 7 , , , cord-010119-t1x9gknd 3371 8 suitable suitable JJ cord-010119-t1x9gknd 3371 9 , , , cord-010119-t1x9gknd 3371 10 and and CC cord-010119-t1x9gknd 3371 11 incompatible incompatible JJ cord-010119-t1x9gknd 3371 12 . . . cord-010119-t1x9gknd 3372 1 The the DT cord-010119-t1x9gknd 3372 2 study study NN cord-010119-t1x9gknd 3372 3 identified identify VBD cord-010119-t1x9gknd 3372 4 no no DT cord-010119-t1x9gknd 3372 5 difference difference NN cord-010119-t1x9gknd 3372 6 between between IN cord-010119-t1x9gknd 3372 7 the the DT cord-010119-t1x9gknd 3372 8 crossmatch crossmatch NN cord-010119-t1x9gknd 3372 9 reaction reaction NN cord-010119-t1x9gknd 3372 10 profiles profile NNS cord-010119-t1x9gknd 3372 11 of of IN cord-010119-t1x9gknd 3372 12 untreated untreated JJ cord-010119-t1x9gknd 3372 13 and and CC cord-010119-t1x9gknd 3372 14 treated treat VBN cord-010119-t1x9gknd 3372 15 RBCs rbc NNS cord-010119-t1x9gknd 3372 16 . . . cord-010119-t1x9gknd 3373 1 Furthermore furthermore RB cord-010119-t1x9gknd 3373 2 , , , cord-010119-t1x9gknd 3373 3 no no DT cord-010119-t1x9gknd 3373 4 difference difference NN cord-010119-t1x9gknd 3373 5 was be VBD cord-010119-t1x9gknd 3373 6 observed observe VBN cord-010119-t1x9gknd 3373 7 in in IN cord-010119-t1x9gknd 3373 8 the the DT cord-010119-t1x9gknd 3373 9 phenotypic phenotypic JJ cord-010119-t1x9gknd 3373 10 state state NN cord-010119-t1x9gknd 3373 11 between between IN cord-010119-t1x9gknd 3373 12 untreated untreated JJ cord-010119-t1x9gknd 3373 13 and and CC cord-010119-t1x9gknd 3373 14 treated treat VBN cord-010119-t1x9gknd 3373 15 RBCs rbc NNS cord-010119-t1x9gknd 3373 16 . . . cord-010119-t1x9gknd 3374 1 Conclusion conclusion NN cord-010119-t1x9gknd 3374 2 : : : cord-010119-t1x9gknd 3375 1 Treatment treatment NN cord-010119-t1x9gknd 3375 2 of of IN cord-010119-t1x9gknd 3375 3 22 22 CD cord-010119-t1x9gknd 3375 4 day day NN cord-010119-t1x9gknd 3375 5 old old JJ cord-010119-t1x9gknd 3375 6 stored store VBN cord-010119-t1x9gknd 3375 7 RBCs rbc NNS cord-010119-t1x9gknd 3375 8 with with IN cord-010119-t1x9gknd 3375 9 the the DT cord-010119-t1x9gknd 3375 10 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3375 11 solution solution NN cord-010119-t1x9gknd 3375 12 had have VBD cord-010119-t1x9gknd 3375 13 no no DT cord-010119-t1x9gknd 3375 14 effect effect NN cord-010119-t1x9gknd 3375 15 on on IN cord-010119-t1x9gknd 3375 16 crossmatch crossmatch NN cord-010119-t1x9gknd 3375 17 reaction reaction NN cord-010119-t1x9gknd 3375 18 profiles profile NNS cord-010119-t1x9gknd 3375 19 or or CC cord-010119-t1x9gknd 3375 20 phenotypic phenotypic JJ cord-010119-t1x9gknd 3375 21 state state NN cord-010119-t1x9gknd 3375 22 when when WRB cord-010119-t1x9gknd 3375 23 compared compare VBN cord-010119-t1x9gknd 3375 24 to to IN cord-010119-t1x9gknd 3375 25 matched match VBN cord-010119-t1x9gknd 3375 26 untreated untreated JJ cord-010119-t1x9gknd 3375 27 samples sample NNS cord-010119-t1x9gknd 3375 28 . . . cord-010119-t1x9gknd 3376 1 Background Background NNP cord-010119-t1x9gknd 3376 2 / / SYM cord-010119-t1x9gknd 3376 3 Case Case NNP cord-010119-t1x9gknd 3376 4 Studies Studies NNPS cord-010119-t1x9gknd 3376 5 : : : cord-010119-t1x9gknd 3377 1 Cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3377 2 platelet platelet NN cord-010119-t1x9gknd 3377 3 production production NN cord-010119-t1x9gknd 3377 4 is be VBZ cord-010119-t1x9gknd 3377 5 burgeoning burgeon VBG cord-010119-t1x9gknd 3377 6 worldwide worldwide RB cord-010119-t1x9gknd 3377 7 . . . cord-010119-t1x9gknd 3378 1 Currently currently RB cord-010119-t1x9gknd 3378 2 , , , cord-010119-t1x9gknd 3378 3 there there EX cord-010119-t1x9gknd 3378 4 are be VBP cord-010119-t1x9gknd 3378 5 no no DT cord-010119-t1x9gknd 3378 6 automated automate VBN cord-010119-t1x9gknd 3378 7 platelet platelet NN cord-010119-t1x9gknd 3378 8 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3378 9 methods method NNS cord-010119-t1x9gknd 3378 10 . . . cord-010119-t1x9gknd 3379 1 By by IN cord-010119-t1x9gknd 3379 2 contrast contrast NN cord-010119-t1x9gknd 3379 3 , , , cord-010119-t1x9gknd 3379 4 red red JJ cord-010119-t1x9gknd 3379 5 blood blood NN cord-010119-t1x9gknd 3379 6 cell cell NN cord-010119-t1x9gknd 3379 7 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3379 8 using use VBG cord-010119-t1x9gknd 3379 9 the the DT cord-010119-t1x9gknd 3379 10 ACP ACP NNP cord-010119-t1x9gknd 3379 11 215 215 CD cord-010119-t1x9gknd 3379 12 ( ( -LRB- cord-010119-t1x9gknd 3379 13 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 3379 14 Corp. Corp. NNP cord-010119-t1x9gknd 3379 15 , , , cord-010119-t1x9gknd 3379 16 Baintree Baintree NNP cord-010119-t1x9gknd 3379 17 , , , cord-010119-t1x9gknd 3379 18 MA MA NNP cord-010119-t1x9gknd 3379 19 ) ) -RRB- cord-010119-t1x9gknd 3379 20 has have VBZ cord-010119-t1x9gknd 3379 21 automated automate VBN cord-010119-t1x9gknd 3379 22 the the DT cord-010119-t1x9gknd 3379 23 processing processing NN cord-010119-t1x9gknd 3379 24 within within IN cord-010119-t1x9gknd 3379 25 a a DT cord-010119-t1x9gknd 3379 26 closed closed JJ cord-010119-t1x9gknd 3379 27 system system NN cord-010119-t1x9gknd 3379 28 , , , cord-010119-t1x9gknd 3379 29 increased increase VBN cord-010119-t1x9gknd 3379 30 labour labour NN cord-010119-t1x9gknd 3379 31 productivity productivity NN cord-010119-t1x9gknd 3379 32 and and CC cord-010119-t1x9gknd 3379 33 provided provide VBD cord-010119-t1x9gknd 3379 34 high high JJ cord-010119-t1x9gknd 3379 35 quality quality NN cord-010119-t1x9gknd 3379 36 blood blood NN cord-010119-t1x9gknd 3379 37 components component NNS cord-010119-t1x9gknd 3379 38 . . . cord-010119-t1x9gknd 3380 1 Purpose purpose NN cord-010119-t1x9gknd 3380 2 : : : cord-010119-t1x9gknd 3380 3 To to TO cord-010119-t1x9gknd 3380 4 automate automate VB cord-010119-t1x9gknd 3380 5 platelet platelet NN cord-010119-t1x9gknd 3380 6 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3380 7 procedure procedure NN cord-010119-t1x9gknd 3380 8 . . . cord-010119-t1x9gknd 3381 1 Study Study NNP cord-010119-t1x9gknd 3381 2 Design Design NNP cord-010119-t1x9gknd 3381 3 / / SYM cord-010119-t1x9gknd 3381 4 Method method NN cord-010119-t1x9gknd 3381 5 : : : cord-010119-t1x9gknd 3382 1 Apheresis apheresis NN cord-010119-t1x9gknd 3382 2 platelet platelet NN cord-010119-t1x9gknd 3382 3 concentrates concentrate VBZ cord-010119-t1x9gknd 3382 4 ( ( -LRB- cord-010119-t1x9gknd 3382 5 PC pc NN cord-010119-t1x9gknd 3382 6 ) ) -RRB- cord-010119-t1x9gknd 3382 7 were be VBD cord-010119-t1x9gknd 3382 8 collected collect VBN cord-010119-t1x9gknd 3382 9 on on IN cord-010119-t1x9gknd 3382 10 the the DT cord-010119-t1x9gknd 3382 11 Trima Trima NNP cord-010119-t1x9gknd 3382 12 Accel Accel NNP cord-010119-t1x9gknd 3382 13 system system NN cord-010119-t1x9gknd 3382 14 . . . cord-010119-t1x9gknd 3383 1 Platelet platelet NN cord-010119-t1x9gknd 3383 2 counts count NNS cord-010119-t1x9gknd 3383 3 were be VBD cord-010119-t1x9gknd 3383 4 performed perform VBN cord-010119-t1x9gknd 3383 5 using use VBG cord-010119-t1x9gknd 3383 6 an an DT cord-010119-t1x9gknd 3383 7 ABX ABX NNP cord-010119-t1x9gknd 3383 8 Micros Micros NNPS cord-010119-t1x9gknd 3383 9 60 60 CD cord-010119-t1x9gknd 3383 10 . . . cord-010119-t1x9gknd 3384 1 PC pc NN cord-010119-t1x9gknd 3384 2 were be VBD cord-010119-t1x9gknd 3384 3 centrifuged centrifuge VBN cord-010119-t1x9gknd 3384 4 at at IN cord-010119-t1x9gknd 3384 5 1250 1250 CD cord-010119-t1x9gknd 3384 6 g g NN cord-010119-t1x9gknd 3384 7 in in IN cord-010119-t1x9gknd 3384 8 a a DT cord-010119-t1x9gknd 3384 9 Sorvall Sorvall NNP cord-010119-t1x9gknd 3384 10 RC3C1 rc3c1 NN cord-010119-t1x9gknd 3384 11 Centrifuge Centrifuge NNP cord-010119-t1x9gknd 3384 12 ( ( -LRB- cord-010119-t1x9gknd 3384 13 Sorvall Sorvall NNP cord-010119-t1x9gknd 3384 14 , , , cord-010119-t1x9gknd 3384 15 USA USA NNP cord-010119-t1x9gknd 3384 16 ) ) -RRB- cord-010119-t1x9gknd 3384 17 for for IN cord-010119-t1x9gknd 3384 18 10 10 CD cord-010119-t1x9gknd 3384 19 min min NN cord-010119-t1x9gknd 3384 20 . . . cord-010119-t1x9gknd 3385 1 The the DT cord-010119-t1x9gknd 3385 2 combination combination NN cord-010119-t1x9gknd 3385 3 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3385 4 DMSO1Dextran DMSO1Dextran . cord-010119-t1x9gknd 3386 1 ( ( -LRB- cord-010119-t1x9gknd 3386 2 CryoSure CryoSure NNP cord-010119-t1x9gknd 3386 3 Dex40 Dex40 NNP cord-010119-t1x9gknd 3386 4 , , , cord-010119-t1x9gknd 3386 5 Germany Germany NNP cord-010119-t1x9gknd 3386 6 ) ) -RRB- cord-010119-t1x9gknd 3386 7 was be VBD cord-010119-t1x9gknd 3386 8 used use VBN cord-010119-t1x9gknd 3386 9 for for IN cord-010119-t1x9gknd 3386 10 PC pc NN cord-010119-t1x9gknd 3386 11 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3386 12 . . . cord-010119-t1x9gknd 3387 1 Cryopreserved Cryopreserved NNP cord-010119-t1x9gknd 3387 2 PC PC NNP cord-010119-t1x9gknd 3387 3 ( ( -LRB- cord-010119-t1x9gknd 3387 4 CPC CPC NNP cord-010119-t1x9gknd 3387 5 ) ) -RRB- cord-010119-t1x9gknd 3387 6 were be VBD cord-010119-t1x9gknd 3387 7 frozen freeze VBN cord-010119-t1x9gknd 3387 8 and and CC cord-010119-t1x9gknd 3387 9 stored store VBN cord-010119-t1x9gknd 3387 10 in in IN cord-010119-t1x9gknd 3387 11 a a DT cord-010119-t1x9gknd 3387 12 Kelvinator Kelvinator NNP cord-010119-t1x9gknd 3387 13 chest chest NN cord-010119-t1x9gknd 3387 14 freezer freezer NN cord-010119-t1x9gknd 3387 15 . . . cord-010119-t1x9gknd 3388 1 CPC CPC NNP cord-010119-t1x9gknd 3388 2 were be VBD cord-010119-t1x9gknd 3388 3 thawed thaw VBN cord-010119-t1x9gknd 3388 4 at at IN cord-010119-t1x9gknd 3388 5 37 37 CD cord-010119-t1x9gknd 3388 6 degrees degree NNS cord-010119-t1x9gknd 3388 7 C c NN cord-010119-t1x9gknd 3388 8 ( ( -LRB- cord-010119-t1x9gknd 3388 9 Barkey Barkey NNP cord-010119-t1x9gknd 3388 10 plasmatherm plasmatherm NNP cord-010119-t1x9gknd 3388 11 ) ) -RRB- cord-010119-t1x9gknd 3388 12 for for IN cord-010119-t1x9gknd 3388 13 10 10 CD cord-010119-t1x9gknd 3388 14 min min NN cord-010119-t1x9gknd 3388 15 . . . cord-010119-t1x9gknd 3389 1 CPC CPC NNP cord-010119-t1x9gknd 3389 2 osmolality osmolality NN cord-010119-t1x9gknd 3389 3 was be VBD cord-010119-t1x9gknd 3389 4 measured measure VBN cord-010119-t1x9gknd 3389 5 with with IN cord-010119-t1x9gknd 3389 6 an an DT cord-010119-t1x9gknd 3389 7 Osmomat Osmomat NNP cord-010119-t1x9gknd 3389 8 030 030 CD cord-010119-t1x9gknd 3389 9 osmometer osmometer NN cord-010119-t1x9gknd 3389 10 . . . cord-010119-t1x9gknd 3390 1 Results/ Results/ . cord-010119-t1x9gknd 3391 1 Finding finding NN cord-010119-t1x9gknd 3391 2 : : : cord-010119-t1x9gknd 3392 1 Staged stage VBN cord-010119-t1x9gknd 3392 2 platelet platelet NN cord-010119-t1x9gknd 3392 3 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3392 4 technology technology NN cord-010119-t1x9gknd 3392 5 has have VBZ cord-010119-t1x9gknd 3392 6 been be VBN cord-010119-t1x9gknd 3392 7 developed develop VBN cord-010119-t1x9gknd 3392 8 . . . cord-010119-t1x9gknd 3393 1 Platelets platelet NNS cord-010119-t1x9gknd 3393 2 were be VBD cord-010119-t1x9gknd 3393 3 cryopreserved cryopreserve VBN cord-010119-t1x9gknd 3393 4 in in IN cord-010119-t1x9gknd 3393 5 a a DT cord-010119-t1x9gknd 3393 6 closed closed JJ cord-010119-t1x9gknd 3393 7 system system NN cord-010119-t1x9gknd 3393 8 ( ( -LRB- cord-010119-t1x9gknd 3394 1 Patent patent NN cord-010119-t1x9gknd 3394 2 No no NN cord-010119-t1x9gknd 3394 3 . . NN cord-010119-t1x9gknd 3394 4 : : : cord-010119-t1x9gknd 3395 1 RU RU NNP cord-010119-t1x9gknd 3395 2 169287 169287 CD cord-010119-t1x9gknd 3395 3 U1 U1 NNP cord-010119-t1x9gknd 3395 4 ) ) -RRB- cord-010119-t1x9gknd 3395 5 . . . cord-010119-t1x9gknd 3396 1 During during IN cord-010119-t1x9gknd 3396 2 the the DT cord-010119-t1x9gknd 3396 3 first first JJ cord-010119-t1x9gknd 3396 4 stage stage NN cord-010119-t1x9gknd 3396 5 , , , cord-010119-t1x9gknd 3396 6 CPC CPC NNP cord-010119-t1x9gknd 3396 7 were be VBD cord-010119-t1x9gknd 3396 8 spun spin VBN cord-010119-t1x9gknd 3396 9 to to TO cord-010119-t1x9gknd 3396 10 separate separate VB cord-010119-t1x9gknd 3396 11 a a DT cord-010119-t1x9gknd 3396 12 plateletrich plateletrich JJ cord-010119-t1x9gknd 3396 13 plasma plasma NN cord-010119-t1x9gknd 3396 14 ( ( -LRB- cord-010119-t1x9gknd 3396 15 PRP prp NN cord-010119-t1x9gknd 3396 16 ) ) -RRB- cord-010119-t1x9gknd 3396 17 fraction fraction NN cord-010119-t1x9gknd 3396 18 from from IN cord-010119-t1x9gknd 3396 19 platelet platelet NN cord-010119-t1x9gknd 3396 20 - - HYPH cord-010119-t1x9gknd 3396 21 poor poor JJ cord-010119-t1x9gknd 3396 22 plasma plasma NN cord-010119-t1x9gknd 3396 23 ( ( -LRB- cord-010119-t1x9gknd 3396 24 PPP PPP NNP cord-010119-t1x9gknd 3396 25 ) ) -RRB- cord-010119-t1x9gknd 3396 26 . . . cord-010119-t1x9gknd 3397 1 The the DT cord-010119-t1x9gknd 3397 2 second second JJ cord-010119-t1x9gknd 3397 3 step step NN cord-010119-t1x9gknd 3397 4 was be VBD cord-010119-t1x9gknd 3397 5 to to TO cord-010119-t1x9gknd 3397 6 resuspend resuspend VB cord-010119-t1x9gknd 3397 7 the the DT cord-010119-t1x9gknd 3397 8 PRP prp NN cord-010119-t1x9gknd 3397 9 by by IN cord-010119-t1x9gknd 3397 10 adding add VBG cord-010119-t1x9gknd 3397 11 a a DT cord-010119-t1x9gknd 3397 12 combination combination NN cord-010119-t1x9gknd 3397 13 of of IN cord-010119-t1x9gknd 3397 14 DMSO1Dextran DMSO1Dextran '' cord-010119-t1x9gknd 3397 15 ( ( -LRB- cord-010119-t1x9gknd 3397 16 CryoSure CryoSure NNP cord-010119-t1x9gknd 3397 17 Dex40 Dex40 NNP cord-010119-t1x9gknd 3397 18 ) ) -RRB- cord-010119-t1x9gknd 3397 19 , , , cord-010119-t1x9gknd 3397 20 as as IN cord-010119-t1x9gknd 3397 21 a a DT cord-010119-t1x9gknd 3397 22 cryoprotectant cryoprotectant NN cord-010119-t1x9gknd 3397 23 , , , cord-010119-t1x9gknd 3397 24 to to TO cord-010119-t1x9gknd 3397 25 obtain obtain VB cord-010119-t1x9gknd 3397 26 a a DT cord-010119-t1x9gknd 3397 27 final final JJ cord-010119-t1x9gknd 3397 28 concentration concentration NN cord-010119-t1x9gknd 3397 29 of of IN cord-010119-t1x9gknd 3397 30 5 5 CD cord-010119-t1x9gknd 3397 31 % % NN cord-010119-t1x9gknd 3397 32 DMSO DMSO NNP cord-010119-t1x9gknd 3397 33 in in IN cord-010119-t1x9gknd 3397 34 the the DT cord-010119-t1x9gknd 3397 35 platelet platelet NN cord-010119-t1x9gknd 3397 36 suspension suspension NN cord-010119-t1x9gknd 3397 37 . . . cord-010119-t1x9gknd 3398 1 The the DT cord-010119-t1x9gknd 3398 2 Injectomat Injectomat NNP cord-010119-t1x9gknd 3398 3 MC MC NNP cord-010119-t1x9gknd 3398 4 Agilia Agilia NNP cord-010119-t1x9gknd 3398 5 and and CC cord-010119-t1x9gknd 3398 6 NPBI NPBI NNP cord-010119-t1x9gknd 3398 7 Compomixer Compomixer NNP cord-010119-t1x9gknd 3398 8 M3 M3 NNP cord-010119-t1x9gknd 3398 9 were be VBD cord-010119-t1x9gknd 3398 10 instrumental instrumental JJ cord-010119-t1x9gknd 3398 11 in in IN cord-010119-t1x9gknd 3398 12 automating automate VBG cord-010119-t1x9gknd 3398 13 that that DT cord-010119-t1x9gknd 3398 14 phase phase NN cord-010119-t1x9gknd 3398 15 . . . cord-010119-t1x9gknd 3399 1 PC pc NN cord-010119-t1x9gknd 3399 2 to to TO cord-010119-t1x9gknd 3399 3 be be VB cord-010119-t1x9gknd 3399 4 frozen freeze VBN cord-010119-t1x9gknd 3399 5 had have VBD cord-010119-t1x9gknd 3399 6 an an DT cord-010119-t1x9gknd 3399 7 osmolality osmolality NN cord-010119-t1x9gknd 3399 8 of of IN cord-010119-t1x9gknd 3399 9 no no DT cord-010119-t1x9gknd 3399 10 less less JJR cord-010119-t1x9gknd 3399 11 than than IN cord-010119-t1x9gknd 3399 12 1500 1500 CD cord-010119-t1x9gknd 3399 13 mOsm mOsm NNP cord-010119-t1x9gknd 3399 14 / / SYM cord-010119-t1x9gknd 3399 15 L. L. NNP cord-010119-t1x9gknd 3399 16 PRP PRP NNP cord-010119-t1x9gknd 3399 17 and and CC cord-010119-t1x9gknd 3399 18 PPP PPP NNP cord-010119-t1x9gknd 3399 19 were be VBD cord-010119-t1x9gknd 3399 20 frozen freeze VBN cord-010119-t1x9gknd 3399 21 at at IN cord-010119-t1x9gknd 3399 22 a a DT cord-010119-t1x9gknd 3399 23 cooling cool VBG cord-010119-t1x9gknd 3399 24 rate rate NN cord-010119-t1x9gknd 3399 25 of of IN cord-010119-t1x9gknd 3399 26 1 1 CD cord-010119-t1x9gknd 3399 27 - - HYPH cord-010119-t1x9gknd 3399 28 38C 38C NNP cord-010119-t1x9gknd 3399 29 / / SYM cord-010119-t1x9gknd 3399 30 min min NN cord-010119-t1x9gknd 3399 31 and and CC cord-010119-t1x9gknd 3399 32 stored store VBN cord-010119-t1x9gknd 3399 33 at at IN cord-010119-t1x9gknd 3399 34 -85 -85 $ cord-010119-t1x9gknd 3399 35 0 0 CD cord-010119-t1x9gknd 3399 36 in in IN cord-010119-t1x9gknd 3399 37 the the DT cord-010119-t1x9gknd 3399 38 chest chest NN cord-010119-t1x9gknd 3399 39 freezer freezer NN cord-010119-t1x9gknd 3399 40 for for IN cord-010119-t1x9gknd 3399 41 up up IN cord-010119-t1x9gknd 3399 42 to to TO cord-010119-t1x9gknd 3399 43 24 24 CD cord-010119-t1x9gknd 3399 44 months month NNS cord-010119-t1x9gknd 3399 45 . . . cord-010119-t1x9gknd 3400 1 Pre pre JJ cord-010119-t1x9gknd 3400 2 - - JJ cord-010119-t1x9gknd 3400 3 transfusion transfusion NN cord-010119-t1x9gknd 3400 4 defrosted defrost VBN cord-010119-t1x9gknd 3400 5 platelets platelet NNS cord-010119-t1x9gknd 3400 6 were be VBD cord-010119-t1x9gknd 3400 7 also also RB cord-010119-t1x9gknd 3400 8 processed process VBN cord-010119-t1x9gknd 3400 9 in in IN cord-010119-t1x9gknd 3400 10 a a DT cord-010119-t1x9gknd 3400 11 closed closed JJ cord-010119-t1x9gknd 3400 12 system system NN cord-010119-t1x9gknd 3400 13 ( ( -LRB- cord-010119-t1x9gknd 3401 1 Patent patent NN cord-010119-t1x9gknd 3401 2 No no NN cord-010119-t1x9gknd 3401 3 . . NN cord-010119-t1x9gknd 3401 4 : : : cord-010119-t1x9gknd 3402 1 RU RU NNP cord-010119-t1x9gknd 3402 2 167874 167874 CD cord-010119-t1x9gknd 3402 3 U1 U1 NNP cord-010119-t1x9gknd 3402 4 ) ) -RRB- cord-010119-t1x9gknd 3402 5 . . . cord-010119-t1x9gknd 3403 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3403 2 transfer transfer NN cord-010119-t1x9gknd 3403 3 set set VBN cord-010119-t1x9gknd 3403 4 made make VBD cord-010119-t1x9gknd 3403 5 it -PRON- PRP cord-010119-t1x9gknd 3403 6 possible possible JJ cord-010119-t1x9gknd 3403 7 to to TO cord-010119-t1x9gknd 3403 8 automate automate VB cord-010119-t1x9gknd 3403 9 platelet platelet NN cord-010119-t1x9gknd 3403 10 resuspension resuspension NN cord-010119-t1x9gknd 3403 11 in in IN cord-010119-t1x9gknd 3403 12 plasma plasma NN cord-010119-t1x9gknd 3403 13 through through IN cord-010119-t1x9gknd 3403 14 the the DT cord-010119-t1x9gknd 3403 15 agency agency NN cord-010119-t1x9gknd 3403 16 of of IN cord-010119-t1x9gknd 3403 17 the the DT cord-010119-t1x9gknd 3403 18 Exadrop Exadrop NNP cord-010119-t1x9gknd 3403 19 V v NN cord-010119-t1x9gknd 3403 20 R r NN cord-010119-t1x9gknd 3403 21 . . . cord-010119-t1x9gknd 3404 1 Post post NN cord-010119-t1x9gknd 3404 2 - - NN cord-010119-t1x9gknd 3404 3 thaw thaw VB cord-010119-t1x9gknd 3404 4 PRP PRP NNP cord-010119-t1x9gknd 3404 5 was be VBD cord-010119-t1x9gknd 3404 6 resuspended resuspend VBN cord-010119-t1x9gknd 3404 7 in in IN cord-010119-t1x9gknd 3404 8 plasma plasma NN cord-010119-t1x9gknd 3404 9 , , , cord-010119-t1x9gknd 3404 10 which which WDT cord-010119-t1x9gknd 3404 11 lowered lower VBD cord-010119-t1x9gknd 3404 12 the the DT cord-010119-t1x9gknd 3404 13 osmolality osmolality NN cord-010119-t1x9gknd 3404 14 to to IN cord-010119-t1x9gknd 3404 15 380 380 CD cord-010119-t1x9gknd 3404 16 mOsm mOsm NNP cord-010119-t1x9gknd 3404 17 / / SYM cord-010119-t1x9gknd 3404 18 L. L. NNP cord-010119-t1x9gknd 3404 19 Freeze Freeze NNP cord-010119-t1x9gknd 3404 20 - - HYPH cord-010119-t1x9gknd 3404 21 thaw thaw VB cord-010119-t1x9gknd 3404 22 recovery recovery NN cord-010119-t1x9gknd 3404 23 of of IN cord-010119-t1x9gknd 3404 24 platelets platelet NNS cord-010119-t1x9gknd 3404 25 was be VBD cord-010119-t1x9gknd 3404 26 80 80 CD cord-010119-t1x9gknd 3404 27 % % NN cord-010119-t1x9gknd 3404 28 or or CC cord-010119-t1x9gknd 3404 29 more more JJR cord-010119-t1x9gknd 3404 30 of of IN cord-010119-t1x9gknd 3404 31 the the DT cord-010119-t1x9gknd 3404 32 original original JJ cord-010119-t1x9gknd 3404 33 population population NN cord-010119-t1x9gknd 3404 34 . . . cord-010119-t1x9gknd 3405 1 Defrosted defrosted JJ cord-010119-t1x9gknd 3405 2 PC PC NNP cord-010119-t1x9gknd 3405 3 were be VBD cord-010119-t1x9gknd 3405 4 stored store VBN cord-010119-t1x9gknd 3405 5 at at IN cord-010119-t1x9gknd 3405 6 20 20 CD cord-010119-t1x9gknd 3405 7 - - SYM cord-010119-t1x9gknd 3405 8 24 24 CD cord-010119-t1x9gknd 3405 9 0 0 CD cord-010119-t1x9gknd 3405 10 with with IN cord-010119-t1x9gknd 3405 11 continuous continuous JJ cord-010119-t1x9gknd 3405 12 gentle gentle JJ cord-010119-t1x9gknd 3405 13 stirring stirring NN cord-010119-t1x9gknd 3405 14 from from IN cord-010119-t1x9gknd 3405 15 a a DT cord-010119-t1x9gknd 3405 16 Helmer Helmer NNP cord-010119-t1x9gknd 3405 17 platelet platelet NN cord-010119-t1x9gknd 3405 18 agitator agitator NN cord-010119-t1x9gknd 3405 19 for for IN cord-010119-t1x9gknd 3405 20 no no DT cord-010119-t1x9gknd 3405 21 longer long JJR cord-010119-t1x9gknd 3405 22 than than IN cord-010119-t1x9gknd 3405 23 4 4 CD cord-010119-t1x9gknd 3405 24 hours hour NNS cord-010119-t1x9gknd 3405 25 before before IN cord-010119-t1x9gknd 3405 26 transfusion transfusion NN cord-010119-t1x9gknd 3405 27 . . . cord-010119-t1x9gknd 3406 1 It -PRON- PRP cord-010119-t1x9gknd 3406 2 took take VBD cord-010119-t1x9gknd 3406 3 no no DT cord-010119-t1x9gknd 3406 4 more more JJR cord-010119-t1x9gknd 3406 5 than than IN cord-010119-t1x9gknd 3406 6 30 30 CD cord-010119-t1x9gknd 3406 7 min min NN cord-010119-t1x9gknd 3406 8 to to TO cord-010119-t1x9gknd 3406 9 cryopreserve cryopreserve VB cord-010119-t1x9gknd 3406 10 PC pc NN cord-010119-t1x9gknd 3406 11 and and CC cord-010119-t1x9gknd 3406 12 process process NN cord-010119-t1x9gknd 3406 13 pre pre JJ cord-010119-t1x9gknd 3406 14 - - NN cord-010119-t1x9gknd 3406 15 transfusion transfusion NN cord-010119-t1x9gknd 3406 16 thawed thaw VBN cord-010119-t1x9gknd 3406 17 platelets platelet NNS cord-010119-t1x9gknd 3406 18 . . . cord-010119-t1x9gknd 3407 1 The the DT cord-010119-t1x9gknd 3407 2 automated automated JJ cord-010119-t1x9gknd 3407 3 processing processing NN cord-010119-t1x9gknd 3407 4 accounted account VBD cord-010119-t1x9gknd 3407 5 for for IN cord-010119-t1x9gknd 3407 6 the the DT cord-010119-t1x9gknd 3407 7 bulk bulk NN cord-010119-t1x9gknd 3407 8 of of IN cord-010119-t1x9gknd 3407 9 the the DT cord-010119-t1x9gknd 3407 10 time time NN cord-010119-t1x9gknd 3407 11 ( ( -LRB- cord-010119-t1x9gknd 3407 12 over over IN cord-010119-t1x9gknd 3407 13 20 20 CD cord-010119-t1x9gknd 3407 14 min min NN cord-010119-t1x9gknd 3407 15 ) ) -RRB- cord-010119-t1x9gknd 3407 16 . . . cord-010119-t1x9gknd 3408 1 Conclusion conclusion NN cord-010119-t1x9gknd 3408 2 : : : cord-010119-t1x9gknd 3409 1 The the DT cord-010119-t1x9gknd 3409 2 automated automate VBN cord-010119-t1x9gknd 3409 3 technique technique NN cord-010119-t1x9gknd 3409 4 developed develop VBN cord-010119-t1x9gknd 3409 5 reduced reduce VBD cord-010119-t1x9gknd 3409 6 the the DT cord-010119-t1x9gknd 3409 7 workload workload NN cord-010119-t1x9gknd 3409 8 while while IN cord-010119-t1x9gknd 3409 9 offering offer VBG cord-010119-t1x9gknd 3409 10 reproducibility reproducibility NN cord-010119-t1x9gknd 3409 11 of of IN cord-010119-t1x9gknd 3409 12 the the DT cord-010119-t1x9gknd 3409 13 procedure procedure NN cord-010119-t1x9gknd 3409 14 and and CC cord-010119-t1x9gknd 3409 15 high high JJ cord-010119-t1x9gknd 3409 16 CPC CPC NNP cord-010119-t1x9gknd 3409 17 quality quality NN cord-010119-t1x9gknd 3409 18 . . . cord-010119-t1x9gknd 3410 1 The the DT cord-010119-t1x9gknd 3410 2 use use NN cord-010119-t1x9gknd 3410 3 of of IN cord-010119-t1x9gknd 3410 4 closed closed JJ cord-010119-t1x9gknd 3410 5 systems system NNS cord-010119-t1x9gknd 3410 6 ruled rule VBD cord-010119-t1x9gknd 3410 7 out out RP cord-010119-t1x9gknd 3410 8 bacterial bacterial JJ cord-010119-t1x9gknd 3410 9 contamination contamination NN cord-010119-t1x9gknd 3410 10 . . . cord-010119-t1x9gknd 3411 1 Employing employ VBG cord-010119-t1x9gknd 3411 2 the the DT cord-010119-t1x9gknd 3411 3 infusion infusion NN cord-010119-t1x9gknd 3411 4 pump pump NN cord-010119-t1x9gknd 3411 5 , , , cord-010119-t1x9gknd 3411 6 platelet platelet NN cord-010119-t1x9gknd 3411 7 stirrer stirrer NN cord-010119-t1x9gknd 3411 8 and and CC cord-010119-t1x9gknd 3411 9 precision precision NN cord-010119-t1x9gknd 3411 10 flow flow NN cord-010119-t1x9gknd 3411 11 regulator regulator NN cord-010119-t1x9gknd 3411 12 enabled enable VBD cord-010119-t1x9gknd 3411 13 adequate adequate JJ cord-010119-t1x9gknd 3411 14 osmolality osmolality NN cord-010119-t1x9gknd 3411 15 monitoring monitoring NN cord-010119-t1x9gknd 3411 16 . . . cord-010119-t1x9gknd 3412 1 Bacterial bacterial JJ cord-010119-t1x9gknd 3412 2 Detection detection NN cord-010119-t1x9gknd 3412 3 in in IN cord-010119-t1x9gknd 3412 4 Leukoreduced Leukoreduced NNP cord-010119-t1x9gknd 3412 5 Apheresis Apheresis NNP cord-010119-t1x9gknd 3412 6 Platelets Platelets NNPS cord-010119-t1x9gknd 3412 7 on on IN cord-010119-t1x9gknd 3412 8 Day Day NNP cord-010119-t1x9gknd 3412 9 4 4 CD cord-010119-t1x9gknd 3412 10 and and CC cord-010119-t1x9gknd 3412 11 Day Day NNP cord-010119-t1x9gknd 3412 12 5 5 CD cord-010119-t1x9gknd 3413 1 Evelyn Evelyn NNP cord-010119-t1x9gknd 3413 2 C. C. NNP cord-010119-t1x9gknd 3413 3 Oyler Oyler NNP cord-010119-t1x9gknd 3414 1 * * NFP cord-010119-t1x9gknd 3414 2 . . . cord-010119-t1x9gknd 3415 1 SunCoast SunCoast NNP cord-010119-t1x9gknd 3415 2 Blood Blood NNP cord-010119-t1x9gknd 3415 3 Bank Bank NNP cord-010119-t1x9gknd 3415 4 Background Background NNP cord-010119-t1x9gknd 3415 5 / / SYM cord-010119-t1x9gknd 3415 6 Case Case NNP cord-010119-t1x9gknd 3415 7 Studies Studies NNPS cord-010119-t1x9gknd 3415 8 : : : cord-010119-t1x9gknd 3416 1 The the DT cord-010119-t1x9gknd 3416 2 recently recently RB cord-010119-t1x9gknd 3416 3 published publish VBN cord-010119-t1x9gknd 3416 4 FDA FDA NNP cord-010119-t1x9gknd 3416 5 draft draft NN cord-010119-t1x9gknd 3416 6 guidance guidance NN cord-010119-t1x9gknd 3416 7 describing describe VBG cord-010119-t1x9gknd 3416 8 bacterial bacterial JJ cord-010119-t1x9gknd 3416 9 testing testing NN cord-010119-t1x9gknd 3416 10 to to TO cord-010119-t1x9gknd 3416 11 enhance enhance VB cord-010119-t1x9gknd 3416 12 the the DT cord-010119-t1x9gknd 3416 13 safety safety NN cord-010119-t1x9gknd 3416 14 and and CC cord-010119-t1x9gknd 3416 15 availability availability NN cord-010119-t1x9gknd 3416 16 of of IN cord-010119-t1x9gknd 3416 17 platelets platelet NNS cord-010119-t1x9gknd 3416 18 outlined outline VBD cord-010119-t1x9gknd 3416 19 the the DT cord-010119-t1x9gknd 3416 20 steps step NNS cord-010119-t1x9gknd 3416 21 for for IN cord-010119-t1x9gknd 3416 22 blood blood NN cord-010119-t1x9gknd 3416 23 collection collection NN cord-010119-t1x9gknd 3416 24 establishments establishment NNS cord-010119-t1x9gknd 3416 25 and and CC cord-010119-t1x9gknd 3416 26 transfusion transfusion NN cord-010119-t1x9gknd 3416 27 services service NNS cord-010119-t1x9gknd 3416 28 to to TO cord-010119-t1x9gknd 3416 29 extend extend VB cord-010119-t1x9gknd 3416 30 apheresis apheresis NN cord-010119-t1x9gknd 3416 31 platelets platelet NNS cord-010119-t1x9gknd 3416 32 dating date VBG cord-010119-t1x9gknd 3416 33 for for IN cord-010119-t1x9gknd 3416 34 up up IN cord-010119-t1x9gknd 3416 35 to to TO cord-010119-t1x9gknd 3416 36 7 7 CD cord-010119-t1x9gknd 3416 37 days day NNS cord-010119-t1x9gknd 3416 38 . . . cord-010119-t1x9gknd 3417 1 This this DT cord-010119-t1x9gknd 3417 2 evaluation evaluation NN cord-010119-t1x9gknd 3417 3 will will MD cord-010119-t1x9gknd 3417 4 compare compare VB cord-010119-t1x9gknd 3417 5 culture culture NN cord-010119-t1x9gknd 3417 6 based base VBN cord-010119-t1x9gknd 3417 7 and and CC cord-010119-t1x9gknd 3417 8 rapid rapid JJ cord-010119-t1x9gknd 3417 9 based base VBN cord-010119-t1x9gknd 3417 10 test test NN cord-010119-t1x9gknd 3417 11 methods method NNS cord-010119-t1x9gknd 3417 12 for for IN cord-010119-t1x9gknd 3417 13 detecting detect VBG cord-010119-t1x9gknd 3417 14 bacterial bacterial JJ cord-010119-t1x9gknd 3417 15 contamination contamination NN cord-010119-t1x9gknd 3417 16 in in IN cord-010119-t1x9gknd 3417 17 apheresis apheresis NN cord-010119-t1x9gknd 3417 18 platelets platelet NNS cord-010119-t1x9gknd 3417 19 . . . cord-010119-t1x9gknd 3418 1 Study Study NNP cord-010119-t1x9gknd 3418 2 Design Design NNP cord-010119-t1x9gknd 3418 3 / / SYM cord-010119-t1x9gknd 3418 4 Method method NN cord-010119-t1x9gknd 3418 5 : : : cord-010119-t1x9gknd 3419 1 A a DT cord-010119-t1x9gknd 3419 2 large large JJ cord-010119-t1x9gknd 3419 3 community community NN cord-010119-t1x9gknd 3419 4 blood blood NN cord-010119-t1x9gknd 3419 5 center center NN cord-010119-t1x9gknd 3419 6 and and CC cord-010119-t1x9gknd 3419 7 transfusion transfusion NN cord-010119-t1x9gknd 3419 8 service service NN cord-010119-t1x9gknd 3419 9 collects collect VBZ cord-010119-t1x9gknd 3419 10 leukoreduced leukoreduced JJ cord-010119-t1x9gknd 3419 11 apheresis apheresis NN cord-010119-t1x9gknd 3419 12 platelets platelet NNS cord-010119-t1x9gknd 3419 13 ( ( -LRB- cord-010119-t1x9gknd 3419 14 LRAP LRAP NNP cord-010119-t1x9gknd 3419 15 ) ) -RRB- cord-010119-t1x9gknd 3419 16 using use VBG cord-010119-t1x9gknd 3419 17 Amicus Amicus NNP cord-010119-t1x9gknd 3419 18 Separator Separator NNP cord-010119-t1x9gknd 3419 19 System System NNP cord-010119-t1x9gknd 3419 20 ( ( -LRB- cord-010119-t1x9gknd 3419 21 Fenwal Fenwal NNP cord-010119-t1x9gknd 3419 22 , , , cord-010119-t1x9gknd 3419 23 Lake Lake NNP cord-010119-t1x9gknd 3419 24 Zurich Zurich NNP cord-010119-t1x9gknd 3419 25 , , , cord-010119-t1x9gknd 3419 26 IL IL NNP cord-010119-t1x9gknd 3419 27 ) ) -RRB- cord-010119-t1x9gknd 3419 28 and and CC cord-010119-t1x9gknd 3419 29 Trima Trima NNP cord-010119-t1x9gknd 3419 30 Accel Accel NNP cord-010119-t1x9gknd 3419 31 System System NNP cord-010119-t1x9gknd 3419 32 ( ( -LRB- cord-010119-t1x9gknd 3419 33 Terumo Terumo NNP cord-010119-t1x9gknd 3419 34 BCT BCT NNP cord-010119-t1x9gknd 3419 35 , , , cord-010119-t1x9gknd 3419 36 Lakewood Lakewood NNP cord-010119-t1x9gknd 3419 37 , , , cord-010119-t1x9gknd 3419 38 CO CO NNP cord-010119-t1x9gknd 3419 39 ) ) -RRB- cord-010119-t1x9gknd 3419 40 . . . cord-010119-t1x9gknd 3420 1 Previously previously RB cord-010119-t1x9gknd 3420 2 - - HYPH cord-010119-t1x9gknd 3420 3 cultured cultured JJ cord-010119-t1x9gknd 3420 4 LRAP LRAP NNP cord-010119-t1x9gknd 3420 5 units unit NNS cord-010119-t1x9gknd 3420 6 were be VBD cord-010119-t1x9gknd 3420 7 sampled sample VBN cord-010119-t1x9gknd 3420 8 on on IN cord-010119-t1x9gknd 3420 9 day day NN cord-010119-t1x9gknd 3420 10 4 4 CD cord-010119-t1x9gknd 3420 11 for for IN cord-010119-t1x9gknd 3420 12 secondary secondary JJ cord-010119-t1x9gknd 3420 13 culture culture NN cord-010119-t1x9gknd 3420 14 using use VBG cord-010119-t1x9gknd 3420 15 BacT BacT NNP cord-010119-t1x9gknd 3420 16 / / SYM cord-010119-t1x9gknd 3420 17 ALERT ALERT NNP cord-010119-t1x9gknd 3420 18 ( ( -LRB- cord-010119-t1x9gknd 3420 19 BioMerieux BioMerieux NNP cord-010119-t1x9gknd 3420 20 , , , cord-010119-t1x9gknd 3420 21 Durham Durham NNP cord-010119-t1x9gknd 3420 22 , , , cord-010119-t1x9gknd 3420 23 NC NC NNP cord-010119-t1x9gknd 3420 24 ) ) -RRB- cord-010119-t1x9gknd 3420 25 and and CC cord-010119-t1x9gknd 3420 26 rapid rapid JJ cord-010119-t1x9gknd 3420 27 bacterial bacterial JJ cord-010119-t1x9gknd 3420 28 tests test NNS cord-010119-t1x9gknd 3420 29 using use VBG cord-010119-t1x9gknd 3420 30 BacTx BacTx NNP cord-010119-t1x9gknd 3420 31 ( ( -LRB- cord-010119-t1x9gknd 3420 32 Immunetics Immunetics NNP cord-010119-t1x9gknd 3420 33 , , , cord-010119-t1x9gknd 3420 34 Boston Boston NNP cord-010119-t1x9gknd 3420 35 , , , cord-010119-t1x9gknd 3420 36 MA MA NNP cord-010119-t1x9gknd 3420 37 ) ) -RRB- cord-010119-t1x9gknd 3420 38 and and CC cord-010119-t1x9gknd 3420 39 PGD PGD NNP cord-010119-t1x9gknd 3420 40 ( ( -LRB- cord-010119-t1x9gknd 3420 41 Verax Verax NNP cord-010119-t1x9gknd 3420 42 , , , cord-010119-t1x9gknd 3420 43 Marlborough Marlborough NNP cord-010119-t1x9gknd 3420 44 , , , cord-010119-t1x9gknd 3420 45 MA MA NNP cord-010119-t1x9gknd 3420 46 ) ) -RRB- cord-010119-t1x9gknd 3420 47 . . . cord-010119-t1x9gknd 3421 1 If if IN cord-010119-t1x9gknd 3421 2 LRAP LRAP NNP cord-010119-t1x9gknd 3421 3 unit unit NN cord-010119-t1x9gknd 3421 4 is be VBZ cord-010119-t1x9gknd 3421 5 still still RB cord-010119-t1x9gknd 3421 6 available available JJ cord-010119-t1x9gknd 3421 7 , , , cord-010119-t1x9gknd 3421 8 it -PRON- PRP cord-010119-t1x9gknd 3421 9 is be VBZ cord-010119-t1x9gknd 3421 10 also also RB cord-010119-t1x9gknd 3421 11 sampled sample VBN cord-010119-t1x9gknd 3421 12 and and CC cord-010119-t1x9gknd 3421 13 tested test VBN cord-010119-t1x9gknd 3421 14 for for IN cord-010119-t1x9gknd 3421 15 rapid rapid JJ cord-010119-t1x9gknd 3421 16 testing testing NN cord-010119-t1x9gknd 3421 17 on on IN cord-010119-t1x9gknd 3421 18 day day NN cord-010119-t1x9gknd 3421 19 5 5 CD cord-010119-t1x9gknd 3421 20 . . . cord-010119-t1x9gknd 3422 1 A a DT cord-010119-t1x9gknd 3422 2 total total NN cord-010119-t1x9gknd 3422 3 of of IN cord-010119-t1x9gknd 3422 4 60 60 CD cord-010119-t1x9gknd 3422 5 LRAP LRAP NNP cord-010119-t1x9gknd 3422 6 units unit NNS cord-010119-t1x9gknd 3422 7 were be VBD cord-010119-t1x9gknd 3422 8 tested test VBN cord-010119-t1x9gknd 3422 9 over over IN cord-010119-t1x9gknd 3422 10 a a DT cord-010119-t1x9gknd 3422 11 3-month 3-month CD cord-010119-t1x9gknd 3422 12 period period NN cord-010119-t1x9gknd 3422 13 : : : cord-010119-t1x9gknd 3422 14 50 50 CD cord-010119-t1x9gknd 3422 15 were be VBD cord-010119-t1x9gknd 3422 16 cultured cultured JJ cord-010119-t1x9gknd 3422 17 and and CC cord-010119-t1x9gknd 3422 18 rapid rapid JJ cord-010119-t1x9gknd 3422 19 tested test VBN cord-010119-t1x9gknd 3422 20 on on IN cord-010119-t1x9gknd 3422 21 day day NN cord-010119-t1x9gknd 3422 22 4 4 CD cord-010119-t1x9gknd 3422 23 ; ; : cord-010119-t1x9gknd 3422 24 10 10 CD cord-010119-t1x9gknd 3422 25 were be VBD cord-010119-t1x9gknd 3422 26 rapid rapid RB cord-010119-t1x9gknd 3422 27 tested test VBN cord-010119-t1x9gknd 3422 28 on on IN cord-010119-t1x9gknd 3422 29 day day NN cord-010119-t1x9gknd 3422 30 5 5 CD cord-010119-t1x9gknd 3422 31 . . . cord-010119-t1x9gknd 3423 1 The the DT cord-010119-t1x9gknd 3423 2 rapid rapid JJ cord-010119-t1x9gknd 3423 3 test test NN cord-010119-t1x9gknd 3423 4 methods method NNS cord-010119-t1x9gknd 3423 5 were be VBD cord-010119-t1x9gknd 3423 6 also also RB cord-010119-t1x9gknd 3423 7 evaluated evaluate VBN cord-010119-t1x9gknd 3423 8 based base VBN cord-010119-t1x9gknd 3423 9 on on IN cord-010119-t1x9gknd 3423 10 cost cost NN cord-010119-t1x9gknd 3423 11 , , , cord-010119-t1x9gknd 3423 12 ease ease NN cord-010119-t1x9gknd 3423 13 of of IN cord-010119-t1x9gknd 3423 14 use use NN cord-010119-t1x9gknd 3423 15 , , , cord-010119-t1x9gknd 3423 16 incubation incubation NN cord-010119-t1x9gknd 3423 17 time time NN cord-010119-t1x9gknd 3423 18 and and CC cord-010119-t1x9gknd 3423 19 indication indication NN cord-010119-t1x9gknd 3423 20 for for IN cord-010119-t1x9gknd 3423 21 use use NN cord-010119-t1x9gknd 3423 22 . . . cord-010119-t1x9gknd 3424 1 Results result NNS cord-010119-t1x9gknd 3424 2 / / SYM cord-010119-t1x9gknd 3424 3 Finding finding NN cord-010119-t1x9gknd 3424 4 : : : cord-010119-t1x9gknd 3424 5 Of of IN cord-010119-t1x9gknd 3424 6 the the DT cord-010119-t1x9gknd 3424 7 LRAP LRAP NNP cord-010119-t1x9gknd 3424 8 units unit NNS cord-010119-t1x9gknd 3424 9 evaluated evaluate VBN cord-010119-t1x9gknd 3424 10 for for IN cord-010119-t1x9gknd 3424 11 this this DT cord-010119-t1x9gknd 3424 12 study study NN cord-010119-t1x9gknd 3424 13 , , , cord-010119-t1x9gknd 3424 14 there there EX cord-010119-t1x9gknd 3424 15 were be VBD cord-010119-t1x9gknd 3424 16 59 59 CD cord-010119-t1x9gknd 3424 17 True true JJ cord-010119-t1x9gknd 3424 18 Negatives Negatives NNPS cord-010119-t1x9gknd 3424 19 ( ( -LRB- cord-010119-t1x9gknd 3424 20 TN TN NNP cord-010119-t1x9gknd 3424 21 ) ) -RRB- cord-010119-t1x9gknd 3424 22 and and CC cord-010119-t1x9gknd 3424 23 1 1 CD cord-010119-t1x9gknd 3424 24 False false JJ cord-010119-t1x9gknd 3424 25 Positive positive JJ cord-010119-t1x9gknd 3424 26 ( ( -LRB- cord-010119-t1x9gknd 3424 27 FP FP NNP cord-010119-t1x9gknd 3424 28 ) ) -RRB- cord-010119-t1x9gknd 3424 29 on on IN cord-010119-t1x9gknd 3424 30 day day NN cord-010119-t1x9gknd 3424 31 1 1 CD cord-010119-t1x9gknd 3424 32 when when WRB cord-010119-t1x9gknd 3424 33 tested test VBN cord-010119-t1x9gknd 3424 34 by by IN cord-010119-t1x9gknd 3424 35 BacT BacT NNP cord-010119-t1x9gknd 3424 36 / / SYM cord-010119-t1x9gknd 3424 37 ALERT ALERT NNP cord-010119-t1x9gknd 3424 38 , , , cord-010119-t1x9gknd 3424 39 with with IN cord-010119-t1x9gknd 3424 40 60 60 CD cord-010119-t1x9gknd 3424 41 TNs tn NNS cord-010119-t1x9gknd 3424 42 on on IN cord-010119-t1x9gknd 3424 43 day day NN cord-010119-t1x9gknd 3424 44 4 4 CD cord-010119-t1x9gknd 3424 45 . . . cord-010119-t1x9gknd 3425 1 BacTx BacTx NNP cord-010119-t1x9gknd 3425 2 testing test VBG cord-010119-t1x9gknd 3425 3 results result NNS cord-010119-t1x9gknd 3425 4 showed show VBD cord-010119-t1x9gknd 3425 5 50 50 CD cord-010119-t1x9gknd 3425 6 TNs tn NNS cord-010119-t1x9gknd 3425 7 on on IN cord-010119-t1x9gknd 3425 8 day day NN cord-010119-t1x9gknd 3425 9 4 4 CD cord-010119-t1x9gknd 3425 10 and and CC cord-010119-t1x9gknd 3425 11 10 10 CD cord-010119-t1x9gknd 3425 12 TNs tn NNS cord-010119-t1x9gknd 3425 13 on on IN cord-010119-t1x9gknd 3425 14 day day NN cord-010119-t1x9gknd 3425 15 5 5 CD cord-010119-t1x9gknd 3425 16 . . . cord-010119-t1x9gknd 3426 1 Testing test VBG cord-010119-t1x9gknd 3426 2 using use VBG cord-010119-t1x9gknd 3426 3 the the DT cord-010119-t1x9gknd 3426 4 PGD PGD NNP cord-010119-t1x9gknd 3426 5 kit kit NN cord-010119-t1x9gknd 3426 6 showed show VBD cord-010119-t1x9gknd 3426 7 50 50 CD cord-010119-t1x9gknd 3426 8 TNs tn NNS cord-010119-t1x9gknd 3426 9 on on IN cord-010119-t1x9gknd 3426 10 day day NN cord-010119-t1x9gknd 3426 11 4 4 CD cord-010119-t1x9gknd 3426 12 ; ; : cord-010119-t1x9gknd 3426 13 and and CC cord-010119-t1x9gknd 3426 14 8 8 CD cord-010119-t1x9gknd 3426 15 TNs tn NNS cord-010119-t1x9gknd 3426 16 and and CC cord-010119-t1x9gknd 3426 17 2 2 CD cord-010119-t1x9gknd 3426 18 FPs fp NNS cord-010119-t1x9gknd 3426 19 on on IN cord-010119-t1x9gknd 3426 20 day day NN cord-010119-t1x9gknd 3426 21 5 5 CD cord-010119-t1x9gknd 3426 22 . . . cord-010119-t1x9gknd 3427 1 FP FP NNP cord-010119-t1x9gknd 3427 2 results result NNS cord-010119-t1x9gknd 3427 3 were be VBD cord-010119-t1x9gknd 3427 4 confirmed confirm VBN cord-010119-t1x9gknd 3427 5 by by IN cord-010119-t1x9gknd 3427 6 performing perform VBG cord-010119-t1x9gknd 3427 7 a a DT cord-010119-t1x9gknd 3427 8 secondary secondary JJ cord-010119-t1x9gknd 3427 9 culture culture NN cord-010119-t1x9gknd 3427 10 , , , cord-010119-t1x9gknd 3427 11 which which WDT cord-010119-t1x9gknd 3427 12 were be VBD cord-010119-t1x9gknd 3427 13 found find VBN cord-010119-t1x9gknd 3427 14 to to TO cord-010119-t1x9gknd 3427 15 be be VB cord-010119-t1x9gknd 3427 16 negative negative JJ cord-010119-t1x9gknd 3427 17 . . . cord-010119-t1x9gknd 3428 1 BacTx BacTx NNP cord-010119-t1x9gknd 3428 2 requires require VBZ cord-010119-t1x9gknd 3428 3 a a DT cord-010119-t1x9gknd 3428 4 specific specific JJ cord-010119-t1x9gknd 3428 5 analyzer analyzer NN cord-010119-t1x9gknd 3428 6 and and CC cord-010119-t1x9gknd 3428 7 30 30 CD cord-010119-t1x9gknd 3428 8 minutes minute NNS cord-010119-t1x9gknd 3428 9 are be VBP cord-010119-t1x9gknd 3428 10 required require VBN cord-010119-t1x9gknd 3428 11 for for IN cord-010119-t1x9gknd 3428 12 result result JJ cord-010119-t1x9gknd 3428 13 interpretation interpretation NN cord-010119-t1x9gknd 3428 14 . . . cord-010119-t1x9gknd 3429 1 There there EX cord-010119-t1x9gknd 3429 2 is be VBZ cord-010119-t1x9gknd 3429 3 no no DT cord-010119-t1x9gknd 3429 4 instrument instrument NN cord-010119-t1x9gknd 3429 5 requirement requirement NN cord-010119-t1x9gknd 3429 6 for for IN cord-010119-t1x9gknd 3429 7 PGD PGD NNP cord-010119-t1x9gknd 3429 8 and and CC cord-010119-t1x9gknd 3429 9 reactions reaction NNS cord-010119-t1x9gknd 3429 10 can can MD cord-010119-t1x9gknd 3429 11 be be VB cord-010119-t1x9gknd 3429 12 read read VBN cord-010119-t1x9gknd 3429 13 within within IN cord-010119-t1x9gknd 3429 14 20 20 CD cord-010119-t1x9gknd 3429 15 minutes minute NNS cord-010119-t1x9gknd 3429 16 . . . cord-010119-t1x9gknd 3430 1 Conclusion conclusion NN cord-010119-t1x9gknd 3430 2 : : : cord-010119-t1x9gknd 3431 1 The the DT cord-010119-t1x9gknd 3431 2 results result NNS cord-010119-t1x9gknd 3431 3 of of IN cord-010119-t1x9gknd 3431 4 this this DT cord-010119-t1x9gknd 3431 5 evaluation evaluation NN cord-010119-t1x9gknd 3431 6 makes make VBZ cord-010119-t1x9gknd 3431 7 PGD PGD NNP cord-010119-t1x9gknd 3431 8 the the DT cord-010119-t1x9gknd 3431 9 best good JJS cord-010119-t1x9gknd 3431 10 fit fit NN cord-010119-t1x9gknd 3431 11 for for IN cord-010119-t1x9gknd 3431 12 this this DT cord-010119-t1x9gknd 3431 13 blood blood NN cord-010119-t1x9gknd 3431 14 center center NN cord-010119-t1x9gknd 3431 15 based base VBN cord-010119-t1x9gknd 3431 16 transfusion transfusion NN cord-010119-t1x9gknd 3431 17 service service NN cord-010119-t1x9gknd 3431 18 . . . cord-010119-t1x9gknd 3432 1 PGD PGD NNP cord-010119-t1x9gknd 3432 2 offers offer VBZ cord-010119-t1x9gknd 3432 3 a a DT cord-010119-t1x9gknd 3432 4 shorter short JJR cord-010119-t1x9gknd 3432 5 time time NN cord-010119-t1x9gknd 3432 6 for for IN cord-010119-t1x9gknd 3432 7 reading reading NN cord-010119-t1x9gknd 3432 8 of of IN cord-010119-t1x9gknd 3432 9 results result NNS cord-010119-t1x9gknd 3432 10 , , , cord-010119-t1x9gknd 3432 11 does do VBZ cord-010119-t1x9gknd 3432 12 not not RB cord-010119-t1x9gknd 3432 13 need need VB cord-010119-t1x9gknd 3432 14 an an DT cord-010119-t1x9gknd 3432 15 initial initial JJ cord-010119-t1x9gknd 3432 16 investment investment NN cord-010119-t1x9gknd 3432 17 for for IN cord-010119-t1x9gknd 3432 18 an an DT cord-010119-t1x9gknd 3432 19 analyzer analyzer NN cord-010119-t1x9gknd 3432 20 and and CC cord-010119-t1x9gknd 3432 21 is be VBZ cord-010119-t1x9gknd 3432 22 indicated indicate VBN cord-010119-t1x9gknd 3432 23 for for IN cord-010119-t1x9gknd 3432 24 LRAP LRAP NNP cord-010119-t1x9gknd 3432 25 in in IN cord-010119-t1x9gknd 3432 26 100 100 CD cord-010119-t1x9gknd 3432 27 % % NN cord-010119-t1x9gknd 3432 28 plasma plasma NN cord-010119-t1x9gknd 3432 29 and and CC cord-010119-t1x9gknd 3432 30 LRAP LRAP NNP cord-010119-t1x9gknd 3432 31 in in IN cord-010119-t1x9gknd 3432 32 PAS pas NN cord-010119-t1x9gknd 3432 33 / / SYM cord-010119-t1x9gknd 3432 34 plasma plasma NN cord-010119-t1x9gknd 3432 35 . . . cord-010119-t1x9gknd 3433 1 Its -PRON- PRP$ cord-010119-t1x9gknd 3433 2 ease ease NN cord-010119-t1x9gknd 3433 3 of of IN cord-010119-t1x9gknd 3433 4 use use NN cord-010119-t1x9gknd 3433 5 allows allow VBZ cord-010119-t1x9gknd 3433 6 for for IN cord-010119-t1x9gknd 3433 7 testing testing NN cord-010119-t1x9gknd 3433 8 of of IN cord-010119-t1x9gknd 3433 9 LRAP LRAP NNP cord-010119-t1x9gknd 3433 10 on on IN cord-010119-t1x9gknd 3433 11 day day NN cord-010119-t1x9gknd 3433 12 4 4 CD cord-010119-t1x9gknd 3433 13 and and CC cord-010119-t1x9gknd 3433 14 day day NN cord-010119-t1x9gknd 3433 15 5 5 CD cord-010119-t1x9gknd 3433 16 during during IN cord-010119-t1x9gknd 3433 17 the the DT cord-010119-t1x9gknd 3433 18 night night NN cord-010119-t1x9gknd 3433 19 shift shift NN cord-010119-t1x9gknd 3433 20 to to TO cord-010119-t1x9gknd 3433 21 be be VB cord-010119-t1x9gknd 3433 22 accomplished accomplish VBN cord-010119-t1x9gknd 3433 23 without without IN cord-010119-t1x9gknd 3433 24 additional additional JJ cord-010119-t1x9gknd 3433 25 staffing staffing NN cord-010119-t1x9gknd 3433 26 and and CC cord-010119-t1x9gknd 3433 27 allows allow VBZ cord-010119-t1x9gknd 3433 28 to to TO cord-010119-t1x9gknd 3433 29 extend extend VB cord-010119-t1x9gknd 3433 30 outdate outdate RB cord-010119-t1x9gknd 3433 31 to to IN cord-010119-t1x9gknd 3433 32 7day 7day NNP cord-010119-t1x9gknd 3433 33 storage storage NN cord-010119-t1x9gknd 3433 34 of of IN cord-010119-t1x9gknd 3433 35 LRAP LRAP NNP cord-010119-t1x9gknd 3433 36 . . . cord-010119-t1x9gknd 3434 1 Change change VB cord-010119-t1x9gknd 3434 2 in in IN cord-010119-t1x9gknd 3434 3 Growth Growth NNP cord-010119-t1x9gknd 3434 4 Factor Factor NNP cord-010119-t1x9gknd 3434 5 Content Content NNP cord-010119-t1x9gknd 3434 6 of of IN cord-010119-t1x9gknd 3434 7 Human Human NNP cord-010119-t1x9gknd 3434 8 Serum Serum NNP cord-010119-t1x9gknd 3434 9 for for IN cord-010119-t1x9gknd 3434 10 Use Use NNP cord-010119-t1x9gknd 3435 1 As as IN cord-010119-t1x9gknd 3435 2 Eye Eye NNP cord-010119-t1x9gknd 3435 3 Drops Drops NNP cord-010119-t1x9gknd 3435 4 during during IN cord-010119-t1x9gknd 3435 5 Frozen Frozen NNP cord-010119-t1x9gknd 3435 6 Storage Storage NNP cord-010119-t1x9gknd 3435 7 for for IN cord-010119-t1x9gknd 3435 8 1 1 CD cord-010119-t1x9gknd 3435 9 Year Year NNP cord-010119-t1x9gknd 3435 10 Jos Jos NNP cord-010119-t1x9gknd 3435 11 Lorinser Lorinser NNP cord-010119-t1x9gknd 3435 12 1 1 CD cord-010119-t1x9gknd 3435 13 , , , cord-010119-t1x9gknd 3435 14 Pieter Pieter NNP cord-010119-t1x9gknd 3435 15 F F NNP cord-010119-t1x9gknd 3435 16 van van NNP cord-010119-t1x9gknd 3435 17 der der NNP cord-010119-t1x9gknd 3435 18 Meer Meer NNP cord-010119-t1x9gknd 3435 19 1 1 CD cord-010119-t1x9gknd 3435 20 , , , cord-010119-t1x9gknd 3435 21 Hans Hans NNP cord-010119-t1x9gknd 3435 22 van van NNP cord-010119-t1x9gknd 3435 23 der der NNP cord-010119-t1x9gknd 3435 24 Heiden Heiden NNP cord-010119-t1x9gknd 3435 25 2 2 CD cord-010119-t1x9gknd 3435 26 and and CC cord-010119-t1x9gknd 3435 27 Dirk Dirk NNP cord-010119-t1x9gknd 3435 28 de de NNP cord-010119-t1x9gknd 3435 29 Korte Korte NNP cord-010119-t1x9gknd 3435 30 * * NFP cord-010119-t1x9gknd 3435 31 1 1 CD cord-010119-t1x9gknd 3435 32 . . . cord-010119-t1x9gknd 3435 33 1 1 CD cord-010119-t1x9gknd 3435 34 Department Department NNP cord-010119-t1x9gknd 3435 35 of of IN cord-010119-t1x9gknd 3435 36 Product Product NNP cord-010119-t1x9gknd 3435 37 and and CC cord-010119-t1x9gknd 3435 38 Process Process NNP cord-010119-t1x9gknd 3435 39 Development Development NNP cord-010119-t1x9gknd 3435 40 , , , cord-010119-t1x9gknd 3435 41 Sanquin Sanquin NNP cord-010119-t1x9gknd 3435 42 Blood Blood NNP cord-010119-t1x9gknd 3435 43 Bank Bank NNP cord-010119-t1x9gknd 3435 44 , , , cord-010119-t1x9gknd 3435 45 2 2 CD cord-010119-t1x9gknd 3435 46 mu mu NN cord-010119-t1x9gknd 3435 47 - - HYPH cord-010119-t1x9gknd 3435 48 Drop Drop NNP cord-010119-t1x9gknd 3435 49 Background Background NNP cord-010119-t1x9gknd 3435 50 / / SYM cord-010119-t1x9gknd 3435 51 Case Case NNP cord-010119-t1x9gknd 3435 52 Studies Studies NNPS cord-010119-t1x9gknd 3435 53 : : : cord-010119-t1x9gknd 3436 1 Growth growth NN cord-010119-t1x9gknd 3436 2 factors factor NNS cord-010119-t1x9gknd 3436 3 are be VBP cord-010119-t1x9gknd 3436 4 thought think VBN cord-010119-t1x9gknd 3436 5 to to TO cord-010119-t1x9gknd 3436 6 be be VB cord-010119-t1x9gknd 3436 7 among among IN cord-010119-t1x9gknd 3436 8 the the DT cord-010119-t1x9gknd 3436 9 active active JJ cord-010119-t1x9gknd 3436 10 components component NNS cord-010119-t1x9gknd 3436 11 in in IN cord-010119-t1x9gknd 3436 12 serum serum NN cord-010119-t1x9gknd 3436 13 used use VBN cord-010119-t1x9gknd 3436 14 for for IN cord-010119-t1x9gknd 3436 15 treatment treatment NN cord-010119-t1x9gknd 3436 16 of of IN cord-010119-t1x9gknd 3436 17 dry dry JJ cord-010119-t1x9gknd 3436 18 - - HYPH cord-010119-t1x9gknd 3436 19 eye eye NN cord-010119-t1x9gknd 3436 20 syndrome syndrome NN cord-010119-t1x9gknd 3436 21 . . . cord-010119-t1x9gknd 3437 1 Stability stability NN cord-010119-t1x9gknd 3437 2 of of IN cord-010119-t1x9gknd 3437 3 growth growth NN cord-010119-t1x9gknd 3437 4 factors factor NNS cord-010119-t1x9gknd 3437 5 during during IN cord-010119-t1x9gknd 3437 6 frozen frozen JJ cord-010119-t1x9gknd 3437 7 storage storage NN cord-010119-t1x9gknd 3437 8 in in IN cord-010119-t1x9gknd 3437 9 mini mini JJ cord-010119-t1x9gknd 3437 10 containers container NNS cord-010119-t1x9gknd 3437 11 ( ( -LRB- cord-010119-t1x9gknd 3437 12 140 140 CD cord-010119-t1x9gknd 3437 13 mL ml NN cord-010119-t1x9gknd 3437 14 ) ) -RRB- cord-010119-t1x9gknd 3437 15 is be VBZ cord-010119-t1x9gknd 3437 16 unknown unknown JJ cord-010119-t1x9gknd 3437 17 . . . cord-010119-t1x9gknd 3438 1 If if IN cord-010119-t1x9gknd 3438 2 these these DT cord-010119-t1x9gknd 3438 3 products product NNS cord-010119-t1x9gknd 3438 4 can can MD cord-010119-t1x9gknd 3438 5 be be VB cord-010119-t1x9gknd 3438 6 stored store VBN cord-010119-t1x9gknd 3438 7 at at IN cord-010119-t1x9gknd 3438 8 -188C -188c NN cord-010119-t1x9gknd 3438 9 it -PRON- PRP cord-010119-t1x9gknd 3438 10 will will MD cord-010119-t1x9gknd 3438 11 be be VB cord-010119-t1x9gknd 3438 12 feasible feasible JJ cord-010119-t1x9gknd 3438 13 to to TO cord-010119-t1x9gknd 3438 14 store store VB cord-010119-t1x9gknd 3438 15 this this DT cord-010119-t1x9gknd 3438 16 product product NN cord-010119-t1x9gknd 3438 17 in in IN cord-010119-t1x9gknd 3438 18 3-star 3-star CD cord-010119-t1x9gknd 3438 19 household household NN cord-010119-t1x9gknd 3438 20 freezers freezer NNS cord-010119-t1x9gknd 3438 21 , , , cord-010119-t1x9gknd 3438 22 making make VBG cord-010119-t1x9gknd 3438 23 the the DT cord-010119-t1x9gknd 3438 24 product product NN cord-010119-t1x9gknd 3438 25 available available JJ cord-010119-t1x9gknd 3438 26 for for IN cord-010119-t1x9gknd 3438 27 patients patient NNS cord-010119-t1x9gknd 3438 28 in in IN cord-010119-t1x9gknd 3438 29 need need NN cord-010119-t1x9gknd 3438 30 of of IN cord-010119-t1x9gknd 3438 31 serum serum NN cord-010119-t1x9gknd 3438 32 eye eye NN cord-010119-t1x9gknd 3438 33 drops drop NNS cord-010119-t1x9gknd 3438 34 . . . cord-010119-t1x9gknd 3439 1 The the DT cord-010119-t1x9gknd 3439 2 purpose purpose NN cord-010119-t1x9gknd 3439 3 of of IN cord-010119-t1x9gknd 3439 4 this this DT cord-010119-t1x9gknd 3439 5 study study NN cord-010119-t1x9gknd 3439 6 is be VBZ cord-010119-t1x9gknd 3439 7 to to TO cord-010119-t1x9gknd 3439 8 demonstrate demonstrate VB cord-010119-t1x9gknd 3439 9 stability stability NN cord-010119-t1x9gknd 3439 10 of of IN cord-010119-t1x9gknd 3439 11 growth growth NN cord-010119-t1x9gknd 3439 12 factor factor NN cord-010119-t1x9gknd 3439 13 content content NN cord-010119-t1x9gknd 3439 14 in in IN cord-010119-t1x9gknd 3439 15 human human JJ cord-010119-t1x9gknd 3439 16 serum serum NN cord-010119-t1x9gknd 3439 17 during during IN cord-010119-t1x9gknd 3439 18 longtime longtime JJ cord-010119-t1x9gknd 3439 19 storage storage NN cord-010119-t1x9gknd 3439 20 at at IN cord-010119-t1x9gknd 3439 21 -188C -188C NNP cord-010119-t1x9gknd 3439 22 or or CC cord-010119-t1x9gknd 3439 23 < < XX cord-010119-t1x9gknd 3439 24 -25 -25 NN cord-010119-t1x9gknd 3439 25 to to IN cord-010119-t1x9gknd 3439 26 -358C -358C . cord-010119-t1x9gknd 3439 27 packed pack VBN cord-010119-t1x9gknd 3439 28 in in IN cord-010119-t1x9gknd 3439 29 a a DT cord-010119-t1x9gknd 3439 30 new new JJ cord-010119-t1x9gknd 3439 31 micro micro JJ cord-010119-t1x9gknd 3439 32 dose dose NN cord-010119-t1x9gknd 3439 33 device device NN cord-010119-t1x9gknd 3439 34 for for IN cord-010119-t1x9gknd 3439 35 single single JJ cord-010119-t1x9gknd 3439 36 use use NN cord-010119-t1x9gknd 3439 37 as as IN cord-010119-t1x9gknd 3439 38 eye eye NN cord-010119-t1x9gknd 3439 39 drops drop NNS cord-010119-t1x9gknd 3439 40 . . . cord-010119-t1x9gknd 3440 1 Study Study NNP cord-010119-t1x9gknd 3440 2 Design Design NNP cord-010119-t1x9gknd 3440 3 / / SYM cord-010119-t1x9gknd 3440 4 Method method NN cord-010119-t1x9gknd 3440 5 : : : cord-010119-t1x9gknd 3440 6 Serum serum NN cord-010119-t1x9gknd 3440 7 produced produce VBD cord-010119-t1x9gknd 3440 8 from from IN cord-010119-t1x9gknd 3440 9 500 500 CD cord-010119-t1x9gknd 3440 10 mL ml NN cord-010119-t1x9gknd 3440 11 whole whole JJ cord-010119-t1x9gknd 3440 12 blood blood NN cord-010119-t1x9gknd 3440 13 donations donation NNS cord-010119-t1x9gknd 3440 14 from from IN cord-010119-t1x9gknd 3440 15 non non JJ cord-010119-t1x9gknd 3440 16 - - JJ cord-010119-t1x9gknd 3440 17 remunerated remunerated JJ cord-010119-t1x9gknd 3440 18 healthy healthy JJ cord-010119-t1x9gknd 3440 19 donors donor NNS cord-010119-t1x9gknd 3440 20 was be VBD cord-010119-t1x9gknd 3440 21 quickly quickly RB cord-010119-t1x9gknd 3440 22 frozen frozen JJ cord-010119-t1x9gknd 3440 23 . . . cord-010119-t1x9gknd 3441 1 After after IN cord-010119-t1x9gknd 3441 2 frozen frozen JJ cord-010119-t1x9gknd 3441 3 storage storage NN cord-010119-t1x9gknd 3441 4 at at IN cord-010119-t1x9gknd 3441 5 < < XX cord-010119-t1x9gknd 3441 6 -258C -258C NNP cord-010119-t1x9gknd 3441 7 for for IN cord-010119-t1x9gknd 3441 8 3 3 CD cord-010119-t1x9gknd 3441 9 - - SYM cord-010119-t1x9gknd 3441 10 12 12 CD cord-010119-t1x9gknd 3441 11 months month NNS cord-010119-t1x9gknd 3441 12 and and CC cord-010119-t1x9gknd 3441 13 controlled control VBN cord-010119-t1x9gknd 3441 14 thawing thawing NN cord-010119-t1x9gknd 3441 15 , , , cord-010119-t1x9gknd 3441 16 six six CD cord-010119-t1x9gknd 3441 17 different different JJ cord-010119-t1x9gknd 3441 18 sera sera NNP cord-010119-t1x9gknd 3441 19 were be VBD cord-010119-t1x9gknd 3441 20 used use VBN cord-010119-t1x9gknd 3441 21 to to TO cord-010119-t1x9gknd 3441 22 fill fill VB cord-010119-t1x9gknd 3441 23 a a DT cord-010119-t1x9gknd 3441 24 large large JJ cord-010119-t1x9gknd 3441 25 number number NN cord-010119-t1x9gknd 3441 26 of of IN cord-010119-t1x9gknd 3441 27 mini mini NN cord-010119-t1x9gknd 3441 28 ( ( -LRB- cord-010119-t1x9gknd 3441 29 140 140 CD cord-010119-t1x9gknd 3441 30 lL lL NNP cord-010119-t1x9gknd 3441 31 ) ) -RRB- cord-010119-t1x9gknd 3441 32 containers container NNS cord-010119-t1x9gknd 3441 33 , , , cord-010119-t1x9gknd 3441 34 which which WDT cord-010119-t1x9gknd 3441 35 were be VBD cord-010119-t1x9gknd 3441 36 refrozen refrozen VBN cord-010119-t1x9gknd 3441 37 and and CC cord-010119-t1x9gknd 3441 38 stored store VBN cord-010119-t1x9gknd 3441 39 at at IN cord-010119-t1x9gknd 3441 40 either either CC cord-010119-t1x9gknd 3441 41 -188C -188C NNP cord-010119-t1x9gknd 3441 42 or or CC cord-010119-t1x9gknd 3441 43 < < XX cord-010119-t1x9gknd 3441 44 -258C. -258C. . cord-010119-t1x9gknd 3442 1 During during IN cord-010119-t1x9gknd 3442 2 storage storage NN cord-010119-t1x9gknd 3442 3 at at IN cord-010119-t1x9gknd 3442 4 3 3 CD cord-010119-t1x9gknd 3442 5 months month NNS cord-010119-t1x9gknd 3442 6 intervals interval NNS cord-010119-t1x9gknd 3442 7 , , , cord-010119-t1x9gknd 3442 8 samples sample NNS cord-010119-t1x9gknd 3442 9 were be VBD cord-010119-t1x9gknd 3442 10 tested test VBN cord-010119-t1x9gknd 3442 11 for for IN cord-010119-t1x9gknd 3442 12 several several JJ cord-010119-t1x9gknd 3442 13 growth growth NN cord-010119-t1x9gknd 3442 14 factors factor NNS cord-010119-t1x9gknd 3442 15 , , , cord-010119-t1x9gknd 3442 16 using use VBG cord-010119-t1x9gknd 3442 17 MagpixV magpixv PRP cord-010119-t1x9gknd 3442 18 R R NNP cord-010119-t1x9gknd 3442 19 Luminex Luminex NNP cord-010119-t1x9gknd 3442 20 Multiplex Multiplex NNP cord-010119-t1x9gknd 3442 21 assays assay NNS cord-010119-t1x9gknd 3442 22 and and CC cord-010119-t1x9gknd 3442 23 compared compare VBN cord-010119-t1x9gknd 3442 24 to to TO cord-010119-t1x9gknd 3442 25 control control NN cord-010119-t1x9gknd 3442 26 samples sample NNS cord-010119-t1x9gknd 3442 27 stored store VBN cord-010119-t1x9gknd 3442 28 at at IN cord-010119-t1x9gknd 3442 29 < < XX cord-010119-t1x9gknd 3442 30 -808C. -808c. WDT cord-010119-t1x9gknd 3442 31 Growth growth NN cord-010119-t1x9gknd 3442 32 factors factor NNS cord-010119-t1x9gknd 3442 33 tested test VBD cord-010119-t1x9gknd 3443 1 were be VBD cord-010119-t1x9gknd 3443 2 PDGF PDGF NNP cord-010119-t1x9gknd 3443 3 - - HYPH cord-010119-t1x9gknd 3443 4 AA&AB AA&AB NNP cord-010119-t1x9gknd 3443 5 / / SYM cord-010119-t1x9gknd 3443 6 BB bb NN cord-010119-t1x9gknd 3443 7 , , , cord-010119-t1x9gknd 3443 8 TGF TGF NNP cord-010119-t1x9gknd 3443 9 - - HYPH cord-010119-t1x9gknd 3443 10 ß1/2/3 ß1/2/3 JJ cord-010119-t1x9gknd 3443 11 , , , cord-010119-t1x9gknd 3443 12 VEGF VEGF NNP cord-010119-t1x9gknd 3443 13 , , , cord-010119-t1x9gknd 3443 14 80A 80a CD cord-010119-t1x9gknd 3443 15 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 3443 16 2017 2017 CD cord-010119-t1x9gknd 3443 17 Vol Vol NNP cord-010119-t1x9gknd 3443 18 . . . cord-010119-t1x9gknd 3444 1 57 57 CD cord-010119-t1x9gknd 3444 2 Supplement Supplement NNP cord-010119-t1x9gknd 3444 3 S3 S3 NNP cord-010119-t1x9gknd 3444 4 EGF EGF NNP cord-010119-t1x9gknd 3444 5 , , , cord-010119-t1x9gknd 3444 6 FGF2 FGF2 NNP cord-010119-t1x9gknd 3444 7 . . . cord-010119-t1x9gknd 3445 1 The the DT cord-010119-t1x9gknd 3445 2 study study NN cord-010119-t1x9gknd 3445 3 was be VBD cord-010119-t1x9gknd 3445 4 a a DT cord-010119-t1x9gknd 3445 5 fact fact NN cord-010119-t1x9gknd 3445 6 - - HYPH cord-010119-t1x9gknd 3445 7 finding find VBG cord-010119-t1x9gknd 3445 8 study study NN cord-010119-t1x9gknd 3445 9 , , , cord-010119-t1x9gknd 3445 10 without without IN cord-010119-t1x9gknd 3445 11 preset preset JJ cord-010119-t1x9gknd 3445 12 acceptance acceptance NN cord-010119-t1x9gknd 3445 13 criteria criterion NNS cord-010119-t1x9gknd 3445 14 . . . cord-010119-t1x9gknd 3446 1 Results/ Results/ . cord-010119-t1x9gknd 3447 1 Finding finding NN cord-010119-t1x9gknd 3447 2 : : : cord-010119-t1x9gknd 3448 1 PDGF PDGF NNP cord-010119-t1x9gknd 3448 2 - - HYPH cord-010119-t1x9gknd 3448 3 AB AB NNP cord-010119-t1x9gknd 3448 4 / / SYM cord-010119-t1x9gknd 3448 5 BB BB NNP cord-010119-t1x9gknd 3448 6 and and CC cord-010119-t1x9gknd 3448 7 TGF TGF NNP cord-010119-t1x9gknd 3448 8 - - HYPH cord-010119-t1x9gknd 3448 9 ß1 ß1 NNP cord-010119-t1x9gknd 3448 10 were be VBD cord-010119-t1x9gknd 3448 11 the the DT cord-010119-t1x9gknd 3448 12 most most RBS cord-010119-t1x9gknd 3448 13 abundant abundant JJ cord-010119-t1x9gknd 3448 14 growth growth NN cord-010119-t1x9gknd 3448 15 factors factor NNS cord-010119-t1x9gknd 3448 16 , , , cord-010119-t1x9gknd 3448 17 on on IN cord-010119-t1x9gknd 3448 18 average average JJ cord-010119-t1x9gknd 3448 19 35 35 CD cord-010119-t1x9gknd 3448 20 , , , cord-010119-t1x9gknd 3448 21 resp resp NNP cord-010119-t1x9gknd 3448 22 . . . cord-010119-t1x9gknd 3449 1 40 40 CD cord-010119-t1x9gknd 3449 2 ng/ ng/ NN cord-010119-t1x9gknd 3450 1 mL. mL. NNP cord-010119-t1x9gknd 3450 2 Also also RB cord-010119-t1x9gknd 3450 3 PDGF PDGF NNP cord-010119-t1x9gknd 3450 4 - - HYPH cord-010119-t1x9gknd 3450 5 AA AA NNP cord-010119-t1x9gknd 3450 6 was be VBD cord-010119-t1x9gknd 3450 7 detected detect VBN cord-010119-t1x9gknd 3450 8 at at IN cord-010119-t1x9gknd 3450 9 relatively relatively RB cord-010119-t1x9gknd 3450 10 high high JJ cord-010119-t1x9gknd 3450 11 concentration concentration NN cord-010119-t1x9gknd 3450 12 in in IN cord-010119-t1x9gknd 3450 13 human human JJ cord-010119-t1x9gknd 3450 14 serum serum NN cord-010119-t1x9gknd 3450 15 , , , cord-010119-t1x9gknd 3450 16 on on IN cord-010119-t1x9gknd 3450 17 average average JJ cord-010119-t1x9gknd 3450 18 11 11 CD cord-010119-t1x9gknd 3450 19 ng ng NN cord-010119-t1x9gknd 3450 20 / / SYM cord-010119-t1x9gknd 3450 21 mL. mL. NNP cord-010119-t1x9gknd 3450 22 TGF TGF NNP cord-010119-t1x9gknd 3450 23 - - HYPH cord-010119-t1x9gknd 3450 24 ß2 ß2 NNP cord-010119-t1x9gknd 3450 25 , , , cord-010119-t1x9gknd 3450 26 EGF EGF NNP cord-010119-t1x9gknd 3450 27 and and CC cord-010119-t1x9gknd 3450 28 VEGF VEGF NNP cord-010119-t1x9gknd 3450 29 were be VBD cord-010119-t1x9gknd 3450 30 detected detect VBN cord-010119-t1x9gknd 3450 31 at at IN cord-010119-t1x9gknd 3450 32 relatively relatively RB cord-010119-t1x9gknd 3450 33 low low JJ cord-010119-t1x9gknd 3450 34 values value NNS cord-010119-t1x9gknd 3450 35 , , , cord-010119-t1x9gknd 3450 36 resp resp NNP cord-010119-t1x9gknd 3450 37 . . . cord-010119-t1x9gknd 3451 1 3 3 CD cord-010119-t1x9gknd 3451 2 ng ng NN cord-010119-t1x9gknd 3451 3 / / SYM cord-010119-t1x9gknd 3451 4 mL ml NN cord-010119-t1x9gknd 3451 5 , , , cord-010119-t1x9gknd 3451 6 0.5 0.5 CD cord-010119-t1x9gknd 3451 7 ng ng NN cord-010119-t1x9gknd 3451 8 / / SYM cord-010119-t1x9gknd 3451 9 mL ml NN cord-010119-t1x9gknd 3451 10 and and CC cord-010119-t1x9gknd 3451 11 0.3 0.3 CD cord-010119-t1x9gknd 3451 12 ng ng NN cord-010119-t1x9gknd 3451 13 / / SYM cord-010119-t1x9gknd 3451 14 mL. ml. NN cord-010119-t1x9gknd 3451 15 Average average JJ cord-010119-t1x9gknd 3451 16 levels level NNS cord-010119-t1x9gknd 3451 17 of of IN cord-010119-t1x9gknd 3451 18 FGF2 FGF2 NNP cord-010119-t1x9gknd 3451 19 and and CC cord-010119-t1x9gknd 3451 20 TGF TGF NNP cord-010119-t1x9gknd 3451 21 - - HYPH cord-010119-t1x9gknd 3451 22 ß3 ß3 NNP cord-010119-t1x9gknd 3451 23 were be VBD cord-010119-t1x9gknd 3451 24 close close JJ cord-010119-t1x9gknd 3451 25 to to IN cord-010119-t1x9gknd 3451 26 detection detection NN cord-010119-t1x9gknd 3451 27 limit limit NN cord-010119-t1x9gknd 3451 28 ( ( -LRB- cord-010119-t1x9gknd 3451 29 < < XX cord-010119-t1x9gknd 3451 30 0.2 0.2 CD cord-010119-t1x9gknd 3451 31 ng ng NN cord-010119-t1x9gknd 3451 32 / / SYM cord-010119-t1x9gknd 3451 33 mL mL NNP cord-010119-t1x9gknd 3451 34 ) ) -RRB- cord-010119-t1x9gknd 3451 35 . . . cord-010119-t1x9gknd 3452 1 The the DT cord-010119-t1x9gknd 3452 2 controls control NNS cord-010119-t1x9gknd 3452 3 stored store VBN cord-010119-t1x9gknd 3452 4 at at IN cord-010119-t1x9gknd 3452 5 < < XX cord-010119-t1x9gknd 3452 6 -808C -808C NNP cord-010119-t1x9gknd 3452 7 showed show VBD cord-010119-t1x9gknd 3452 8 for for IN cord-010119-t1x9gknd 3452 9 all all DT cord-010119-t1x9gknd 3452 10 growth growth NN cord-010119-t1x9gknd 3452 11 factors factor NNS cord-010119-t1x9gknd 3452 12 close close VBP cord-010119-t1x9gknd 3452 13 to to IN cord-010119-t1x9gknd 3452 14 100 100 CD cord-010119-t1x9gknd 3452 15 % % NN cord-010119-t1x9gknd 3452 16 of of IN cord-010119-t1x9gknd 3452 17 the the DT cord-010119-t1x9gknd 3452 18 initial initial JJ cord-010119-t1x9gknd 3452 19 values value NNS cord-010119-t1x9gknd 3452 20 in in IN cord-010119-t1x9gknd 3452 21 samples sample NNS cord-010119-t1x9gknd 3452 22 at at IN cord-010119-t1x9gknd 3452 23 T50 T50 NNP cord-010119-t1x9gknd 3452 24 ( ( -LRB- cord-010119-t1x9gknd 3452 25 moment moment NN cord-010119-t1x9gknd 3452 26 of of IN cord-010119-t1x9gknd 3452 27 filling fill VBG cord-010119-t1x9gknd 3452 28 mini mini JJ cord-010119-t1x9gknd 3452 29 containers container NNS cord-010119-t1x9gknd 3452 30 ) ) -RRB- cord-010119-t1x9gknd 3452 31 . . . cord-010119-t1x9gknd 3453 1 For for IN cord-010119-t1x9gknd 3453 2 serum serum NN cord-010119-t1x9gknd 3453 3 stored store VBN cord-010119-t1x9gknd 3453 4 at at IN cord-010119-t1x9gknd 3453 5 < < XX cord-010119-t1x9gknd 3453 6 -258C -258C NNP cord-010119-t1x9gknd 3453 7 for for IN cord-010119-t1x9gknd 3453 8 up up IN cord-010119-t1x9gknd 3453 9 to to TO cord-010119-t1x9gknd 3453 10 12 12 CD cord-010119-t1x9gknd 3453 11 months month NNS cord-010119-t1x9gknd 3453 12 , , , cord-010119-t1x9gknd 3453 13 most most JJS cord-010119-t1x9gknd 3453 14 factors factor NNS cord-010119-t1x9gknd 3453 15 showed show VBD cord-010119-t1x9gknd 3453 16 less less JJR cord-010119-t1x9gknd 3453 17 than than IN cord-010119-t1x9gknd 3453 18 2 2 CD cord-010119-t1x9gknd 3453 19 % % NN cord-010119-t1x9gknd 3453 20 decrease decrease NN cord-010119-t1x9gknd 3453 21 , , , cord-010119-t1x9gknd 3453 22 except except IN cord-010119-t1x9gknd 3453 23 for for IN cord-010119-t1x9gknd 3453 24 PDGF PDGF NNP cord-010119-t1x9gknd 3453 25 - - HYPH cord-010119-t1x9gknd 3453 26 AA AA NNP cord-010119-t1x9gknd 3453 27 and and CC cord-010119-t1x9gknd 3453 28 TGF TGF NNP cord-010119-t1x9gknd 3453 29 - - HYPH cord-010119-t1x9gknd 3453 30 ß2 ß2 NNP cord-010119-t1x9gknd 3453 31 , , , cord-010119-t1x9gknd 3453 32 showing show VBG cord-010119-t1x9gknd 3453 33 6 6 CD cord-010119-t1x9gknd 3453 34 % % NN cord-010119-t1x9gknd 3453 35 resp resp NN cord-010119-t1x9gknd 3453 36 . . . cord-010119-t1x9gknd 3454 1 3 3 CD cord-010119-t1x9gknd 3454 2 % % NN cord-010119-t1x9gknd 3454 3 lower low JJR cord-010119-t1x9gknd 3454 4 values value NNS cord-010119-t1x9gknd 3454 5 . . . cord-010119-t1x9gknd 3455 1 For for IN cord-010119-t1x9gknd 3455 2 serum serum NN cord-010119-t1x9gknd 3455 3 stored store VBN cord-010119-t1x9gknd 3455 4 at at IN cord-010119-t1x9gknd 3455 5 -188C -188c NN cord-010119-t1x9gknd 3456 1 the the DT cord-010119-t1x9gknd 3456 2 values value NNS cord-010119-t1x9gknd 3456 3 for for IN cord-010119-t1x9gknd 3456 4 TGF TGF NNP cord-010119-t1x9gknd 3456 5 - - HYPH cord-010119-t1x9gknd 3456 6 ß1 ß1 NNP cord-010119-t1x9gknd 3456 7 , , , cord-010119-t1x9gknd 3456 8 EGF EGF NNP cord-010119-t1x9gknd 3456 9 and and CC cord-010119-t1x9gknd 3456 10 VEGF VEGF NNP cord-010119-t1x9gknd 3456 11 were be VBD cord-010119-t1x9gknd 3456 12 stable stable JJ cord-010119-t1x9gknd 3456 13 , , , cord-010119-t1x9gknd 3456 14 whereas whereas IN cord-010119-t1x9gknd 3456 15 PDGF PDGF NNP cord-010119-t1x9gknd 3456 16 - - HYPH cord-010119-t1x9gknd 3456 17 AB AB NNP cord-010119-t1x9gknd 3456 18 / / SYM cord-010119-t1x9gknd 3456 19 BB bb NN cord-010119-t1x9gknd 3456 20 , , , cord-010119-t1x9gknd 3456 21 PDGF PDGF NNP cord-010119-t1x9gknd 3456 22 - - HYPH cord-010119-t1x9gknd 3456 23 AA AA NNP cord-010119-t1x9gknd 3456 24 and and CC cord-010119-t1x9gknd 3456 25 TGF TGF NNP cord-010119-t1x9gknd 3456 26 - - HYPH cord-010119-t1x9gknd 3456 27 ß2 ß2 NNP cord-010119-t1x9gknd 3456 28 showed show VBD cord-010119-t1x9gknd 3456 29 a a DT cord-010119-t1x9gknd 3456 30 decrease decrease NN cord-010119-t1x9gknd 3456 31 of of IN cord-010119-t1x9gknd 3456 32 resp resp NN cord-010119-t1x9gknd 3456 33 . . . cord-010119-t1x9gknd 3457 1 9 9 CD cord-010119-t1x9gknd 3457 2 , , , cord-010119-t1x9gknd 3457 3 17 17 CD cord-010119-t1x9gknd 3457 4 and and CC cord-010119-t1x9gknd 3457 5 3 3 CD cord-010119-t1x9gknd 3457 6 % % NN cord-010119-t1x9gknd 3457 7 . . . cord-010119-t1x9gknd 3458 1 Conclusion conclusion NN cord-010119-t1x9gknd 3458 2 : : : cord-010119-t1x9gknd 3458 3 Human human JJ cord-010119-t1x9gknd 3458 4 serum serum NN cord-010119-t1x9gknd 3458 5 eye eye NN cord-010119-t1x9gknd 3458 6 drops drop NNS cord-010119-t1x9gknd 3458 7 can can MD cord-010119-t1x9gknd 3458 8 be be VB cord-010119-t1x9gknd 3458 9 stored store VBN cord-010119-t1x9gknd 3458 10 in in IN cord-010119-t1x9gknd 3458 11 the the DT cord-010119-t1x9gknd 3458 12 new new JJ cord-010119-t1x9gknd 3458 13 micro micro JJ cord-010119-t1x9gknd 3458 14 dose dose NN cord-010119-t1x9gknd 3458 15 device device NN cord-010119-t1x9gknd 3458 16 at at IN cord-010119-t1x9gknd 3458 17 -188C -188C . cord-010119-t1x9gknd 3459 1 ( ( -LRB- cord-010119-t1x9gknd 3459 2 3-star 3-star CD cord-010119-t1x9gknd 3459 3 household household NN cord-010119-t1x9gknd 3459 4 freezers freezer NNS cord-010119-t1x9gknd 3459 5 ) ) -RRB- cord-010119-t1x9gknd 3459 6 or or CC cord-010119-t1x9gknd 3459 7 < < XX cord-010119-t1x9gknd 3459 8 -258C -258C NNP cord-010119-t1x9gknd 3459 9 ( ( -LRB- cord-010119-t1x9gknd 3459 10 professional professional JJ cord-010119-t1x9gknd 3459 11 freezers freezer NNS cord-010119-t1x9gknd 3459 12 ) ) -RRB- cord-010119-t1x9gknd 3460 1 for for IN cord-010119-t1x9gknd 3460 2 at at RB cord-010119-t1x9gknd 3460 3 least least RBS cord-010119-t1x9gknd 3460 4 one one CD cord-010119-t1x9gknd 3460 5 year year NN cord-010119-t1x9gknd 3460 6 after after IN cord-010119-t1x9gknd 3460 7 preparation preparation NN cord-010119-t1x9gknd 3460 8 without without IN cord-010119-t1x9gknd 3460 9 large large JJ cord-010119-t1x9gknd 3460 10 decreases decrease NNS cord-010119-t1x9gknd 3460 11 in in IN cord-010119-t1x9gknd 3460 12 growth growth NN cord-010119-t1x9gknd 3460 13 factor factor NN cord-010119-t1x9gknd 3460 14 content content NN cord-010119-t1x9gknd 3460 15 . . . cord-010119-t1x9gknd 3461 1 The the DT cord-010119-t1x9gknd 3461 2 maximum maximum JJ cord-010119-t1x9gknd 3461 3 decrease decrease NN cord-010119-t1x9gknd 3461 4 was be VBD cord-010119-t1x9gknd 3461 5 found find VBN cord-010119-t1x9gknd 3461 6 for for IN cord-010119-t1x9gknd 3461 7 PDGF PDGF NNP cord-010119-t1x9gknd 3461 8 - - HYPH cord-010119-t1x9gknd 3461 9 AA AA NNP cord-010119-t1x9gknd 3461 10 in in IN cord-010119-t1x9gknd 3461 11 serum serum NN cord-010119-t1x9gknd 3461 12 stored store VBN cord-010119-t1x9gknd 3461 13 at at IN cord-010119-t1x9gknd 3461 14 -188C. -188C. . cord-010119-t1x9gknd 3462 1 It -PRON- PRP cord-010119-t1x9gknd 3462 2 is be VBZ cord-010119-t1x9gknd 3462 3 yet yet RB cord-010119-t1x9gknd 3462 4 unknown unknown JJ cord-010119-t1x9gknd 3462 5 if if IN cord-010119-t1x9gknd 3462 6 the the DT cord-010119-t1x9gknd 3462 7 tested test VBN cord-010119-t1x9gknd 3462 8 components component NNS cord-010119-t1x9gknd 3462 9 add add VBP cord-010119-t1x9gknd 3462 10 to to IN cord-010119-t1x9gknd 3462 11 the the DT cord-010119-t1x9gknd 3462 12 in in IN cord-010119-t1x9gknd 3462 13 vivo vivo NN cord-010119-t1x9gknd 3462 14 effectiveness effectiveness NN cord-010119-t1x9gknd 3462 15 of of IN cord-010119-t1x9gknd 3462 16 serum serum NN cord-010119-t1x9gknd 3462 17 eye eye NN cord-010119-t1x9gknd 3462 18 drops drop VBZ cord-010119-t1x9gknd 3462 19 and and CC cord-010119-t1x9gknd 3462 20 what what WP cord-010119-t1x9gknd 3462 21 the the DT cord-010119-t1x9gknd 3462 22 minimal minimal JJ cord-010119-t1x9gknd 3462 23 concentration concentration NN cord-010119-t1x9gknd 3462 24 is be VBZ cord-010119-t1x9gknd 3462 25 to to TO cord-010119-t1x9gknd 3462 26 ensure ensure VB cord-010119-t1x9gknd 3462 27 in in IN cord-010119-t1x9gknd 3462 28 vivo vivo NN cord-010119-t1x9gknd 3462 29 effectiveness effectiveness NN cord-010119-t1x9gknd 3462 30 . . . cord-010119-t1x9gknd 3463 1 Further further JJ cord-010119-t1x9gknd 3463 2 stability stability NN cord-010119-t1x9gknd 3463 3 testing testing NN cord-010119-t1x9gknd 3463 4 in in IN cord-010119-t1x9gknd 3463 5 combination combination NN cord-010119-t1x9gknd 3463 6 with with IN cord-010119-t1x9gknd 3463 7 in in IN cord-010119-t1x9gknd 3463 8 vitro vitro FW cord-010119-t1x9gknd 3463 9 and and CC cord-010119-t1x9gknd 3463 10 in in IN cord-010119-t1x9gknd 3463 11 vivo vivo NN cord-010119-t1x9gknd 3463 12 application application NN cord-010119-t1x9gknd 3463 13 is be VBZ cord-010119-t1x9gknd 3463 14 required require VBN cord-010119-t1x9gknd 3463 15 to to TO cord-010119-t1x9gknd 3463 16 extend extend VB cord-010119-t1x9gknd 3463 17 the the DT cord-010119-t1x9gknd 3463 18 shelf shelf NN cord-010119-t1x9gknd 3463 19 - - HYPH cord-010119-t1x9gknd 3463 20 life life NN cord-010119-t1x9gknd 3463 21 beyond beyond IN cord-010119-t1x9gknd 3463 22 1 1 CD cord-010119-t1x9gknd 3463 23 year year NN cord-010119-t1x9gknd 3463 24 . . . cord-010119-t1x9gknd 3464 1 Ruqayyah Ruqayyah NNP cord-010119-t1x9gknd 3464 2 Almizraq Almizraq NNP cord-010119-t1x9gknd 3464 3 * * NFP cord-010119-t1x9gknd 3464 4 1 1 CD cord-010119-t1x9gknd 3464 5 , , , cord-010119-t1x9gknd 3464 6 Heather Heather NNP cord-010119-t1x9gknd 3464 7 Inglis Inglis NNP cord-010119-t1x9gknd 3464 8 2 2 CD cord-010119-t1x9gknd 3464 9 , , , cord-010119-t1x9gknd 3464 10 Phillip Phillip NNP cord-010119-t1x9gknd 3464 11 Norris Norris NNP cord-010119-t1x9gknd 3464 12 2,3 2,3 CD cord-010119-t1x9gknd 3464 13 , , , cord-010119-t1x9gknd 3464 14 Jennifer Jennifer NNP cord-010119-t1x9gknd 3464 15 A A NNP cord-010119-t1x9gknd 3464 16 Muszynski Muszynski NNP cord-010119-t1x9gknd 3464 17 4 4 CD cord-010119-t1x9gknd 3464 18 , , , cord-010119-t1x9gknd 3464 19 Nicole Nicole NNP cord-010119-t1x9gknd 3464 20 Juffermans Juffermans NNP cord-010119-t1x9gknd 3464 21 5 5 CD cord-010119-t1x9gknd 3464 22 , , , cord-010119-t1x9gknd 3464 23 Jelena Jelena NNP cord-010119-t1x9gknd 3464 24 Holovati Holovati NNP cord-010119-t1x9gknd 3464 25 1 1 CD cord-010119-t1x9gknd 3464 26 and and CC cord-010119-t1x9gknd 3464 27 Jason Jason NNP cord-010119-t1x9gknd 3464 28 P. P. NNP cord-010119-t1x9gknd 3464 29 Acker Acker NNP cord-010119-t1x9gknd 3464 30 1,6 1,6 CD cord-010119-t1x9gknd 3464 31 . . . cord-010119-t1x9gknd 3465 1 1 1 CD cord-010119-t1x9gknd 3465 2 University University NNP cord-010119-t1x9gknd 3465 3 of of IN cord-010119-t1x9gknd 3465 4 Alberta Alberta NNP cord-010119-t1x9gknd 3465 5 , , , cord-010119-t1x9gknd 3465 6 2 2 CD cord-010119-t1x9gknd 3465 7 Blood Blood NNP cord-010119-t1x9gknd 3465 8 Systems Systems NNPS cord-010119-t1x9gknd 3465 9 Research Research NNP cord-010119-t1x9gknd 3465 10 Institute Institute NNP cord-010119-t1x9gknd 3465 11 , , , cord-010119-t1x9gknd 3465 12 3 3 CD cord-010119-t1x9gknd 3465 13 University University NNP cord-010119-t1x9gknd 3465 14 of of IN cord-010119-t1x9gknd 3465 15 California California NNP cord-010119-t1x9gknd 3465 16 , , , cord-010119-t1x9gknd 3465 17 San San NNP cord-010119-t1x9gknd 3465 18 Francisco Francisco NNP cord-010119-t1x9gknd 3465 19 , , , cord-010119-t1x9gknd 3465 20 4 4 CD cord-010119-t1x9gknd 3465 21 Nationwide Nationwide NNP cord-010119-t1x9gknd 3465 22 Children Children NNPS cord-010119-t1x9gknd 3465 23 's 's POS cord-010119-t1x9gknd 3465 24 Hospital Hospital NNP cord-010119-t1x9gknd 3465 25 , , , cord-010119-t1x9gknd 3465 26 5 5 CD cord-010119-t1x9gknd 3465 27 Academic Academic NNP cord-010119-t1x9gknd 3465 28 Medical Medical NNP cord-010119-t1x9gknd 3465 29 Center Center NNP cord-010119-t1x9gknd 3465 30 , , , cord-010119-t1x9gknd 3465 31 6 6 CD cord-010119-t1x9gknd 3465 32 Canadian Canadian NNP cord-010119-t1x9gknd 3465 33 Blood Blood NNP cord-010119-t1x9gknd 3465 34 Services Services NNPS cord-010119-t1x9gknd 3465 35 Background Background NNP cord-010119-t1x9gknd 3465 36 / / SYM cord-010119-t1x9gknd 3465 37 Case Case NNP cord-010119-t1x9gknd 3465 38 Studies Studies NNPS cord-010119-t1x9gknd 3465 39 : : : cord-010119-t1x9gknd 3465 40 Different different JJ cord-010119-t1x9gknd 3465 41 blood blood NN cord-010119-t1x9gknd 3465 42 manufacturing manufacturing NN cord-010119-t1x9gknd 3465 43 methods method NNS cord-010119-t1x9gknd 3465 44 can can MD cord-010119-t1x9gknd 3465 45 influence influence VB cord-010119-t1x9gknd 3465 46 residual residual JJ cord-010119-t1x9gknd 3465 47 cell cell NN cord-010119-t1x9gknd 3465 48 numbers number NNS cord-010119-t1x9gknd 3465 49 and and CC cord-010119-t1x9gknd 3465 50 membrane membrane NN cord-010119-t1x9gknd 3465 51 vesiculation vesiculation NN cord-010119-t1x9gknd 3465 52 , , , cord-010119-t1x9gknd 3465 53 which which WDT cord-010119-t1x9gknd 3465 54 may may MD cord-010119-t1x9gknd 3465 55 affect affect VB cord-010119-t1x9gknd 3465 56 quality quality NN cord-010119-t1x9gknd 3465 57 and and CC cord-010119-t1x9gknd 3465 58 safety safety NN cord-010119-t1x9gknd 3465 59 of of IN cord-010119-t1x9gknd 3465 60 blood blood NN cord-010119-t1x9gknd 3465 61 components component NNS cord-010119-t1x9gknd 3465 62 . . . cord-010119-t1x9gknd 3466 1 The the DT cord-010119-t1x9gknd 3466 2 aim aim NN cord-010119-t1x9gknd 3466 3 was be VBD cord-010119-t1x9gknd 3466 4 to to TO cord-010119-t1x9gknd 3466 5 identify identify VB cord-010119-t1x9gknd 3466 6 , , , cord-010119-t1x9gknd 3466 7 quantify quantify VB cord-010119-t1x9gknd 3466 8 and and CC cord-010119-t1x9gknd 3466 9 characterize characterize VB cord-010119-t1x9gknd 3466 10 residual residual JJ cord-010119-t1x9gknd 3466 11 cells cell NNS cord-010119-t1x9gknd 3466 12 and and CC cord-010119-t1x9gknd 3466 13 extracellular extracellular JJ cord-010119-t1x9gknd 3466 14 vesicles vesicle NNS cord-010119-t1x9gknd 3466 15 ( ( -LRB- cord-010119-t1x9gknd 3466 16 EVs ev NNS cord-010119-t1x9gknd 3466 17 ) ) -RRB- cord-010119-t1x9gknd 3466 18 in in IN cord-010119-t1x9gknd 3466 19 stored store VBN cord-010119-t1x9gknd 3466 20 RBC RBC NNP cord-010119-t1x9gknd 3466 21 products product NNS cord-010119-t1x9gknd 3466 22 produced produce VBN cord-010119-t1x9gknd 3466 23 by by IN cord-010119-t1x9gknd 3466 24 different different JJ cord-010119-t1x9gknd 3466 25 blood blood NN cord-010119-t1x9gknd 3466 26 manufacturing manufacturing NN cord-010119-t1x9gknd 3466 27 methods method NNS cord-010119-t1x9gknd 3466 28 . . . cord-010119-t1x9gknd 3467 1 Study Study NNP cord-010119-t1x9gknd 3467 2 Design Design NNP cord-010119-t1x9gknd 3467 3 / / SYM cord-010119-t1x9gknd 3467 4 Methods method NNS cord-010119-t1x9gknd 3467 5 : : : cord-010119-t1x9gknd 3468 1 Thirty thirty CD cord-010119-t1x9gknd 3468 2 - - HYPH cord-010119-t1x9gknd 3468 3 two two CD cord-010119-t1x9gknd 3468 4 RBC RBC NNP cord-010119-t1x9gknd 3468 5 units unit NNS cord-010119-t1x9gknd 3468 6 produced produce VBD cord-010119-t1x9gknd 3468 7 using use VBG cord-010119-t1x9gknd 3468 8 whole whole JJ cord-010119-t1x9gknd 3468 9 blood blood NN cord-010119-t1x9gknd 3468 10 filtration filtration NN cord-010119-t1x9gknd 3468 11 ( ( -LRB- cord-010119-t1x9gknd 3468 12 WBF WBF NNP cord-010119-t1x9gknd 3468 13 ) ) -RRB- cord-010119-t1x9gknd 3468 14 , , , cord-010119-t1x9gknd 3468 15 red red JJ cord-010119-t1x9gknd 3468 16 cell cell NN cord-010119-t1x9gknd 3468 17 filtration filtration NN cord-010119-t1x9gknd 3468 18 ( ( -LRB- cord-010119-t1x9gknd 3468 19 RCF RCF NNP cord-010119-t1x9gknd 3468 20 ) ) -RRB- cord-010119-t1x9gknd 3468 21 , , , cord-010119-t1x9gknd 3468 22 apheresis apheresis NN cord-010119-t1x9gknd 3468 23 , , , cord-010119-t1x9gknd 3468 24 and and CC cord-010119-t1x9gknd 3468 25 whole whole JJ cord-010119-t1x9gknd 3468 26 blood blood NN cord-010119-t1x9gknd 3468 27 derived derive VBN cord-010119-t1x9gknd 3468 28 ( ( -LRB- cord-010119-t1x9gknd 3468 29 WBD WBD NNP cord-010119-t1x9gknd 3468 30 ) ) -RRB- cord-010119-t1x9gknd 3468 31 methods method NNS cord-010119-t1x9gknd 3468 32 were be VBD cord-010119-t1x9gknd 3468 33 examined examine VBN cord-010119-t1x9gknd 3468 34 ( ( -LRB- cord-010119-t1x9gknd 3468 35 n58 n58 JJ cord-010119-t1x9gknd 3468 36 per per IN cord-010119-t1x9gknd 3468 37 method method NN cord-010119-t1x9gknd 3468 38 ) ) -RRB- cord-010119-t1x9gknd 3468 39 . . . cord-010119-t1x9gknd 3469 1 Residual residual JJ cord-010119-t1x9gknd 3469 2 platelets platelet NNS cord-010119-t1x9gknd 3469 3 and and CC cord-010119-t1x9gknd 3469 4 white white JJ cord-010119-t1x9gknd 3469 5 blood blood NN cord-010119-t1x9gknd 3469 6 cells cell NNS cord-010119-t1x9gknd 3469 7 ( ( -LRB- cord-010119-t1x9gknd 3469 8 WBCs wbc NNS cord-010119-t1x9gknd 3469 9 ) ) -RRB- cord-010119-t1x9gknd 3469 10 were be VBD cord-010119-t1x9gknd 3469 11 measured measure VBN cord-010119-t1x9gknd 3469 12 on on IN cord-010119-t1x9gknd 3469 13 day day NN cord-010119-t1x9gknd 3469 14 5 5 CD cord-010119-t1x9gknd 3469 15 using use VBG cord-010119-t1x9gknd 3469 16 flow flow NN cord-010119-t1x9gknd 3469 17 cytometer cytometer NN cord-010119-t1x9gknd 3469 18 ( ( -LRB- cord-010119-t1x9gknd 3469 19 FC FC NNP cord-010119-t1x9gknd 3469 20 ) ) -RRB- cord-010119-t1x9gknd 3469 21 . . . cord-010119-t1x9gknd 3470 1 On on IN cord-010119-t1x9gknd 3470 2 storage storage NN cord-010119-t1x9gknd 3470 3 day day NN cord-010119-t1x9gknd 3470 4 5 5 CD cord-010119-t1x9gknd 3470 5 and and CC cord-010119-t1x9gknd 3470 6 42 42 CD cord-010119-t1x9gknd 3470 7 , , , cord-010119-t1x9gknd 3470 8 number number NN cord-010119-t1x9gknd 3470 9 and and CC cord-010119-t1x9gknd 3470 10 cell cell NN cord-010119-t1x9gknd 3470 11 of of IN cord-010119-t1x9gknd 3470 12 origin origin NN cord-010119-t1x9gknd 3470 13 / / SYM cord-010119-t1x9gknd 3470 14 surface surface NN cord-010119-t1x9gknd 3470 15 markers marker NNS cord-010119-t1x9gknd 3470 16 of of IN cord-010119-t1x9gknd 3470 17 EVs ev NNS cord-010119-t1x9gknd 3470 18 were be VBD cord-010119-t1x9gknd 3470 19 assessed assess VBN cord-010119-t1x9gknd 3470 20 with with IN cord-010119-t1x9gknd 3470 21 FC FC NNP cord-010119-t1x9gknd 3470 22 , , , cord-010119-t1x9gknd 3470 23 and and CC cord-010119-t1x9gknd 3470 24 concentration concentration NN cord-010119-t1x9gknd 3470 25 and and CC cord-010119-t1x9gknd 3470 26 size size NN cord-010119-t1x9gknd 3470 27 - - HYPH cord-010119-t1x9gknd 3470 28 profile profile NN cord-010119-t1x9gknd 3470 29 of of IN cord-010119-t1x9gknd 3470 30 EVs ev NNS cord-010119-t1x9gknd 3470 31 were be VBD cord-010119-t1x9gknd 3470 32 examined examine VBN cord-010119-t1x9gknd 3470 33 using use VBG cord-010119-t1x9gknd 3470 34 tunable tunable JJ cord-010119-t1x9gknd 3470 35 resistive resistive JJ cord-010119-t1x9gknd 3470 36 plus plus CC cord-010119-t1x9gknd 3470 37 sensing sensing NN cord-010119-t1x9gknd 3470 38 ( ( -LRB- cord-010119-t1x9gknd 3470 39 TRPS TRPS NNP cord-010119-t1x9gknd 3470 40 ) ) -RRB- cord-010119-t1x9gknd 3470 41 . . . cord-010119-t1x9gknd 3471 1 Results result NNS cord-010119-t1x9gknd 3471 2 / / SYM cord-010119-t1x9gknd 3471 3 Findings finding NNS cord-010119-t1x9gknd 3471 4 : : : cord-010119-t1x9gknd 3472 1 On on IN cord-010119-t1x9gknd 3472 2 day day NN cord-010119-t1x9gknd 3472 3 5 5 CD cord-010119-t1x9gknd 3472 4 , , , cord-010119-t1x9gknd 3472 5 apheresis apheresis NN cord-010119-t1x9gknd 3472 6 and and CC cord-010119-t1x9gknd 3472 7 WBD WBD NNP cord-010119-t1x9gknd 3472 8 units unit NNS cord-010119-t1x9gknd 3472 9 had have VBD cord-010119-t1x9gknd 3472 10 significantly significantly RB cord-010119-t1x9gknd 3472 11 greater great JJR cord-010119-t1x9gknd 3472 12 residual residual JJ cord-010119-t1x9gknd 3472 13 platelets platelet NNS cord-010119-t1x9gknd 3472 14 in in IN cord-010119-t1x9gknd 3472 15 comparisons comparison NNS cord-010119-t1x9gknd 3472 16 to to IN cord-010119-t1x9gknd 3472 17 RCF RCF NNP cord-010119-t1x9gknd 3472 18 ( ( -LRB- cord-010119-t1x9gknd 3472 19 vs vs IN cord-010119-t1x9gknd 3472 20 : : : cord-010119-t1x9gknd 3472 21 apheresis apheresis NN cord-010119-t1x9gknd 3472 22 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 3472 23 , , , cord-010119-t1x9gknd 3472 24 WBD WBD NNP cord-010119-t1x9gknd 3472 25 p<0.05 p<0.05 CD cord-010119-t1x9gknd 3472 26 ) ) -RRB- cord-010119-t1x9gknd 3472 27 and and CC cord-010119-t1x9gknd 3472 28 WBF WBF NNP cord-010119-t1x9gknd 3472 29 ( ( -LRB- cord-010119-t1x9gknd 3472 30 vs vs IN cord-010119-t1x9gknd 3472 31 : : : cord-010119-t1x9gknd 3472 32 apheresis apheresis NN cord-010119-t1x9gknd 3472 33 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 3472 34 , , , cord-010119-t1x9gknd 3472 35 WBD WBD NNP cord-010119-t1x9gknd 3472 36 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 3472 37 ) ) -RRB- cord-010119-t1x9gknd 3472 38 methods method NNS cord-010119-t1x9gknd 3472 39 . . . cord-010119-t1x9gknd 3473 1 While while IN cord-010119-t1x9gknd 3473 2 RCF RCF NNP cord-010119-t1x9gknd 3473 3 units unit NNS cord-010119-t1x9gknd 3473 4 yielded yield VBD cord-010119-t1x9gknd 3473 5 the the DT cord-010119-t1x9gknd 3473 6 lowest low JJS cord-010119-t1x9gknd 3473 7 count count NN cord-010119-t1x9gknd 3473 8 of of IN cord-010119-t1x9gknd 3473 9 Platelet platelet NN cord-010119-t1x9gknd 3473 10 - - HYPH cord-010119-t1x9gknd 3473 11 EVs EVs NNP cord-010119-t1x9gknd 3473 12 ( ( -LRB- cord-010119-t1x9gknd 3473 13 CD41a1 CD41a1 NNP cord-010119-t1x9gknd 3473 14 ) ) -RRB- cord-010119-t1x9gknd 3473 15 on on IN cord-010119-t1x9gknd 3473 16 day day NN cord-010119-t1x9gknd 3473 17 5 5 CD cord-010119-t1x9gknd 3473 18 and and CC cord-010119-t1x9gknd 3473 19 42 42 CD cord-010119-t1x9gknd 3473 20 , , , cord-010119-t1x9gknd 3473 21 the the DT cord-010119-t1x9gknd 3473 22 highest high JJS cord-010119-t1x9gknd 3473 23 number number NN cord-010119-t1x9gknd 3473 24 of of IN cord-010119-t1x9gknd 3473 25 Platelet platelet NN cord-010119-t1x9gknd 3473 26 - - HYPH cord-010119-t1x9gknd 3473 27 EVs ev NNS cord-010119-t1x9gknd 3473 28 were be VBD cord-010119-t1x9gknd 3473 29 in in IN cord-010119-t1x9gknd 3473 30 apheresis apheresis NN cord-010119-t1x9gknd 3473 31 ( ( -LRB- cord-010119-t1x9gknd 3473 32 day day NN cord-010119-t1x9gknd 3473 33 5 5 CD cord-010119-t1x9gknd 3473 34 ) ) -RRB- cord-010119-t1x9gknd 3473 35 and and CC cord-010119-t1x9gknd 3473 36 in in IN cord-010119-t1x9gknd 3473 37 WBD WBD NNP cord-010119-t1x9gknd 3473 38 ( ( -LRB- cord-010119-t1x9gknd 3473 39 day day NN cord-010119-t1x9gknd 3473 40 42 42 CD cord-010119-t1x9gknd 3473 41 ) ) -RRB- cord-010119-t1x9gknd 3473 42 . . . cord-010119-t1x9gknd 3474 1 Similarly similarly RB cord-010119-t1x9gknd 3474 2 , , , cord-010119-t1x9gknd 3474 3 there there EX cord-010119-t1x9gknd 3474 4 was be VBD cord-010119-t1x9gknd 3474 5 significant significant JJ cord-010119-t1x9gknd 3474 6 difference difference NN cord-010119-t1x9gknd 3474 7 among among IN cord-010119-t1x9gknd 3474 8 methods method NNS cord-010119-t1x9gknd 3474 9 in in IN cord-010119-t1x9gknd 3474 10 the the DT cord-010119-t1x9gknd 3474 11 number number NN cord-010119-t1x9gknd 3474 12 of of IN cord-010119-t1x9gknd 3474 13 WBC WBC NNP cord-010119-t1x9gknd 3474 14 - - HYPH cord-010119-t1x9gknd 3474 15 EVs EVs NNP cord-010119-t1x9gknd 3474 16 ( ( -LRB- cord-010119-t1x9gknd 3474 17 CD31 CD31 NNP cord-010119-t1x9gknd 3474 18 , , , cord-010119-t1x9gknd 3474 19 CD141 CD141 NNP cord-010119-t1x9gknd 3474 20 , , , cord-010119-t1x9gknd 3474 21 CD161 CD161 NNP cord-010119-t1x9gknd 3474 22 , , , cord-010119-t1x9gknd 3474 23 CD191 cd191 NN cord-010119-t1x9gknd 3474 24 , , , cord-010119-t1x9gknd 3474 25 CD66b1 CD66b1 NNP cord-010119-t1x9gknd 3474 26 ) ) -RRB- cord-010119-t1x9gknd 3474 27 and and CC cord-010119-t1x9gknd 3474 28 RCF RCF NNP cord-010119-t1x9gknd 3474 29 contained contain VBD cord-010119-t1x9gknd 3474 30 the the DT cord-010119-t1x9gknd 3474 31 smallest small JJS cord-010119-t1x9gknd 3474 32 concentration concentration NN cord-010119-t1x9gknd 3474 33 . . . cord-010119-t1x9gknd 3475 1 Moreover moreover RB cord-010119-t1x9gknd 3475 2 , , , cord-010119-t1x9gknd 3475 3 both both CC cord-010119-t1x9gknd 3475 4 TRPS TRPS NNP cord-010119-t1x9gknd 3475 5 and and CC cord-010119-t1x9gknd 3475 6 FC FC NNP cord-010119-t1x9gknd 3475 7 showed show VBD cord-010119-t1x9gknd 3475 8 an an DT cord-010119-t1x9gknd 3475 9 increase increase NN cord-010119-t1x9gknd 3475 10 in in IN cord-010119-t1x9gknd 3475 11 the the DT cord-010119-t1x9gknd 3475 12 total total JJ cord-010119-t1x9gknd 3475 13 number number NN cord-010119-t1x9gknd 3475 14 of of IN cord-010119-t1x9gknd 3475 15 EVs ev NNS cord-010119-t1x9gknd 3475 16 on on IN cord-010119-t1x9gknd 3475 17 day day NN cord-010119-t1x9gknd 3475 18 42 42 CD cord-010119-t1x9gknd 3475 19 vs vs IN cord-010119-t1x9gknd 3475 20 day day NN cord-010119-t1x9gknd 3475 21 5 5 CD cord-010119-t1x9gknd 3475 22 in in IN cord-010119-t1x9gknd 3475 23 all all DT cord-010119-t1x9gknd 3475 24 of of IN cord-010119-t1x9gknd 3475 25 the the DT cord-010119-t1x9gknd 3475 26 processing processing NN cord-010119-t1x9gknd 3475 27 methods method NNS cord-010119-t1x9gknd 3475 28 . . . cord-010119-t1x9gknd 3476 1 Noteworthy noteworthy JJ cord-010119-t1x9gknd 3476 2 , , , cord-010119-t1x9gknd 3476 3 TRPS TRPS NNP cord-010119-t1x9gknd 3476 4 showed show VBD cord-010119-t1x9gknd 3476 5 that that IN cord-010119-t1x9gknd 3476 6 the the DT cord-010119-t1x9gknd 3476 7 number number NN cord-010119-t1x9gknd 3476 8 of of IN cord-010119-t1x9gknd 3476 9 small small JJ cord-010119-t1x9gknd 3476 10 EVs ev NNS cord-010119-t1x9gknd 3476 11 / / SYM cord-010119-t1x9gknd 3476 12 exosomes exosomes NNP cord-010119-t1x9gknd 3476 13 ( ( -LRB- cord-010119-t1x9gknd 3476 14 < < XX cord-010119-t1x9gknd 3476 15 200 200 CD cord-010119-t1x9gknd 3476 16 nm nm NN cord-010119-t1x9gknd 3476 17 ) ) -RRB- cord-010119-t1x9gknd 3476 18 was be VBD cord-010119-t1x9gknd 3476 19 greater great JJR cord-010119-t1x9gknd 3476 20 than than IN cord-010119-t1x9gknd 3476 21 large large JJ cord-010119-t1x9gknd 3476 22 EVs ev NNS cord-010119-t1x9gknd 3476 23 ( ( -LRB- cord-010119-t1x9gknd 3476 24 ! ! . cord-010119-t1x9gknd 3476 25 200 200 CD cord-010119-t1x9gknd 3476 26 nm nm CD cord-010119-t1x9gknd 3476 27 ) ) -RRB- cord-010119-t1x9gknd 3476 28 in in IN cord-010119-t1x9gknd 3476 29 all all DT cord-010119-t1x9gknd 3476 30 of of IN cord-010119-t1x9gknd 3476 31 the the DT cord-010119-t1x9gknd 3476 32 products product NNS cord-010119-t1x9gknd 3476 33 on on IN cord-010119-t1x9gknd 3476 34 day day NN cord-010119-t1x9gknd 3476 35 5 5 CD cord-010119-t1x9gknd 3476 36 and and CC cord-010119-t1x9gknd 3476 37 42 42 CD cord-010119-t1x9gknd 3476 38 , , , cord-010119-t1x9gknd 3476 39 and and CC cord-010119-t1x9gknd 3476 40 the the DT cord-010119-t1x9gknd 3476 41 highest high JJS cord-010119-t1x9gknd 3476 42 level level NN cord-010119-t1x9gknd 3476 43 of of IN cord-010119-t1x9gknd 3476 44 EVs ev NNS cord-010119-t1x9gknd 3476 45 < < XX cord-010119-t1x9gknd 3476 46 200 200 CD cord-010119-t1x9gknd 3476 47 nm nm NN cord-010119-t1x9gknd 3476 48 were be VBD cord-010119-t1x9gknd 3476 49 in in IN cord-010119-t1x9gknd 3476 50 apheresis apheresis NN cord-010119-t1x9gknd 3476 51 units unit NNS cord-010119-t1x9gknd 3476 52 . . . cord-010119-t1x9gknd 3477 1 TRPS TRPS NNP cord-010119-t1x9gknd 3477 2 results result NNS cord-010119-t1x9gknd 3477 3 also also RB cord-010119-t1x9gknd 3477 4 showed show VBD cord-010119-t1x9gknd 3477 5 a a DT cord-010119-t1x9gknd 3477 6 significant significant JJ cord-010119-t1x9gknd 3477 7 difference difference NN cord-010119-t1x9gknd 3477 8 in in IN cord-010119-t1x9gknd 3477 9 the the DT cord-010119-t1x9gknd 3477 10 EVs evs NN cord-010119-t1x9gknd 3477 11 size size NN cord-010119-t1x9gknd 3477 12 - - : cord-010119-t1x9gknd 3477 13 profile profile NN cord-010119-t1x9gknd 3477 14 amongst amongst IN cord-010119-t1x9gknd 3477 15 all all DT cord-010119-t1x9gknd 3477 16 RBC RBC NNP cord-010119-t1x9gknd 3477 17 products product NNS cord-010119-t1x9gknd 3477 18 ( ( -LRB- cord-010119-t1x9gknd 3477 19 p<0.05 p<0.05 CD cord-010119-t1x9gknd 3477 20 ) ) -RRB- cord-010119-t1x9gknd 3477 21 . . . cord-010119-t1x9gknd 3478 1 Conclusion conclusion NN cord-010119-t1x9gknd 3478 2 : : : cord-010119-t1x9gknd 3479 1 This this DT cord-010119-t1x9gknd 3479 2 study study NN cord-010119-t1x9gknd 3479 3 shows show VBZ cord-010119-t1x9gknd 3479 4 that that IN cord-010119-t1x9gknd 3479 5 the the DT cord-010119-t1x9gknd 3479 6 method method NN cord-010119-t1x9gknd 3479 7 of of IN cord-010119-t1x9gknd 3479 8 manufacturing manufacture VBG cord-010119-t1x9gknd 3479 9 significantly significantly RB cord-010119-t1x9gknd 3479 10 affects affect VBZ cord-010119-t1x9gknd 3479 11 RBC RBC NNP cord-010119-t1x9gknd 3479 12 and and CC cord-010119-t1x9gknd 3479 13 non non JJ cord-010119-t1x9gknd 3479 14 - - JJ cord-010119-t1x9gknd 3479 15 RBCs rbcs JJ cord-010119-t1x9gknd 3479 16 EVs ev NNS cord-010119-t1x9gknd 3479 17 characteristics characteristic NNS cord-010119-t1x9gknd 3479 18 throughout throughout IN cord-010119-t1x9gknd 3479 19 storage storage NN cord-010119-t1x9gknd 3479 20 , , , cord-010119-t1x9gknd 3479 21 which which WDT cord-010119-t1x9gknd 3479 22 has have VBZ cord-010119-t1x9gknd 3479 23 the the DT cord-010119-t1x9gknd 3479 24 potential potential NN cord-010119-t1x9gknd 3479 25 to to TO cord-010119-t1x9gknd 3479 26 impact impact VB cord-010119-t1x9gknd 3479 27 quality quality NN cord-010119-t1x9gknd 3479 28 and and CC cord-010119-t1x9gknd 3479 29 safety safety NN cord-010119-t1x9gknd 3479 30 of of IN cord-010119-t1x9gknd 3479 31 RBC RBC NNP cord-010119-t1x9gknd 3479 32 products product NNS cord-010119-t1x9gknd 3479 33 . . . cord-010119-t1x9gknd 3480 1 The the DT cord-010119-t1x9gknd 3480 2 differences difference NNS cord-010119-t1x9gknd 3480 3 in in IN cord-010119-t1x9gknd 3480 4 the the DT cord-010119-t1x9gknd 3480 5 EVs EVs NNP cord-010119-t1x9gknd 3480 6 cell cell NN cord-010119-t1x9gknd 3480 7 - - HYPH cord-010119-t1x9gknd 3480 8 of of IN cord-010119-t1x9gknd 3480 9 - - HYPH cord-010119-t1x9gknd 3480 10 origin origin NN cord-010119-t1x9gknd 3480 11 , , , cord-010119-t1x9gknd 3480 12 concentration concentration NN cord-010119-t1x9gknd 3480 13 , , , cord-010119-t1x9gknd 3480 14 and and CC cord-010119-t1x9gknd 3480 15 size size NN cord-010119-t1x9gknd 3480 16 - - HYPH cord-010119-t1x9gknd 3480 17 profile profile NN cord-010119-t1x9gknd 3480 18 observed observe VBN cord-010119-t1x9gknd 3480 19 between between IN cord-010119-t1x9gknd 3480 20 manufacturing manufacturing NN cord-010119-t1x9gknd 3480 21 methods method NNS cord-010119-t1x9gknd 3480 22 , , , cord-010119-t1x9gknd 3480 23 warrants warrant NNS cord-010119-t1x9gknd 3480 24 further further JJ cord-010119-t1x9gknd 3480 25 examination examination NN cord-010119-t1x9gknd 3480 26 of of IN cord-010119-t1x9gknd 3480 27 their -PRON- PRP$ cord-010119-t1x9gknd 3480 28 potential potential JJ cord-010119-t1x9gknd 3480 29 immunomodulatory immunomodulatory JJ cord-010119-t1x9gknd 3480 30 effects effect NNS cord-010119-t1x9gknd 3480 31 and and CC cord-010119-t1x9gknd 3480 32 clinical clinical JJ cord-010119-t1x9gknd 3480 33 consequences consequence NNS cord-010119-t1x9gknd 3480 34 . . . cord-010119-t1x9gknd 3481 1 Coagulation coagulation NN cord-010119-t1x9gknd 3481 2 and and CC cord-010119-t1x9gknd 3481 3 Complement Complement NNP cord-010119-t1x9gknd 3481 4 Assays Assays NNPS cord-010119-t1x9gknd 3481 5 in in IN cord-010119-t1x9gknd 3481 6 Whole Whole NNP cord-010119-t1x9gknd 3481 7 Blood blood NN cord-010119-t1x9gknd 3482 1 Stored store VBN cord-010119-t1x9gknd 3482 2 at at IN cord-010119-t1x9gknd 3482 3 48 48 CD cord-010119-t1x9gknd 3482 4 Centigrade Centigrade NNP cord-010119-t1x9gknd 3482 5 Maryanne Maryanne NNP cord-010119-t1x9gknd 3482 6 C C NNP cord-010119-t1x9gknd 3482 7 Herzig Herzig NNP cord-010119-t1x9gknd 3482 8 * * NFP cord-010119-t1x9gknd 3482 9 1 1 CD cord-010119-t1x9gknd 3482 10 , , , cord-010119-t1x9gknd 3482 11 Crystal Crystal NNP cord-010119-t1x9gknd 3482 12 Lafleur Lafleur NNP cord-010119-t1x9gknd 3482 13 2 2 CD cord-010119-t1x9gknd 3482 14 , , , cord-010119-t1x9gknd 3482 15 Chriselda Chriselda NNP cord-010119-t1x9gknd 3482 16 G G NNP cord-010119-t1x9gknd 3482 17 Fedyk Fedyk NNP cord-010119-t1x9gknd 3482 18 1 1 CD cord-010119-t1x9gknd 3482 19 , , , cord-010119-t1x9gknd 3482 20 Sherrill Sherrill NNP cord-010119-t1x9gknd 3482 21 J. J. NNP cord-010119-t1x9gknd 3482 22 Slichter Slichter NNP cord-010119-t1x9gknd 3482 23 3 3 CD cord-010119-t1x9gknd 3482 24 and and CC cord-010119-t1x9gknd 3482 25 Andrew Andrew NNP cord-010119-t1x9gknd 3482 26 P P NNP cord-010119-t1x9gknd 3482 27 Cap Cap NNP cord-010119-t1x9gknd 3482 28 2 2 CD cord-010119-t1x9gknd 3482 29 . . . cord-010119-t1x9gknd 3483 1 1 1 LS cord-010119-t1x9gknd 3484 1 US US NNP cord-010119-t1x9gknd 3484 2 Army Army NNP cord-010119-t1x9gknd 3484 3 Institute Institute NNP cord-010119-t1x9gknd 3484 4 of of IN cord-010119-t1x9gknd 3484 5 Surgical Surgical NNP cord-010119-t1x9gknd 3484 6 Research Research NNP cord-010119-t1x9gknd 3484 7 , , , cord-010119-t1x9gknd 3484 8 2 2 CD cord-010119-t1x9gknd 3484 9 U.S. U.S. NNP cord-010119-t1x9gknd 3484 10 Army Army NNP cord-010119-t1x9gknd 3484 11 Institute Institute NNP cord-010119-t1x9gknd 3484 12 of of IN cord-010119-t1x9gknd 3484 13 Surgical Surgical NNP cord-010119-t1x9gknd 3484 14 Research Research NNP cord-010119-t1x9gknd 3484 15 , , , cord-010119-t1x9gknd 3484 16 3 3 CD cord-010119-t1x9gknd 3484 17 University University NNP cord-010119-t1x9gknd 3484 18 of of IN cord-010119-t1x9gknd 3484 19 Washington Washington NNP cord-010119-t1x9gknd 3484 20 Background Background NNP cord-010119-t1x9gknd 3484 21 / / SYM cord-010119-t1x9gknd 3484 22 Case Case NNP cord-010119-t1x9gknd 3484 23 Studies Studies NNPS cord-010119-t1x9gknd 3485 1 : : : cord-010119-t1x9gknd 3485 2 Whole whole JJ cord-010119-t1x9gknd 3485 3 blood blood NN cord-010119-t1x9gknd 3485 4 has have VBZ cord-010119-t1x9gknd 3485 5 been be VBN cord-010119-t1x9gknd 3485 6 demonstrated demonstrate VBN cord-010119-t1x9gknd 3485 7 to to TO cord-010119-t1x9gknd 3485 8 retain retain VB cord-010119-t1x9gknd 3485 9 hemostatic hemostatic JJ cord-010119-t1x9gknd 3485 10 activity activity NN cord-010119-t1x9gknd 3485 11 , , , cord-010119-t1x9gknd 3485 12 including include VBG cord-010119-t1x9gknd 3485 13 platelet platelet NN cord-010119-t1x9gknd 3485 14 aggregation aggregation NN cord-010119-t1x9gknd 3485 15 function function NN cord-010119-t1x9gknd 3485 16 , , , cord-010119-t1x9gknd 3485 17 over over IN cord-010119-t1x9gknd 3485 18 at at RB cord-010119-t1x9gknd 3485 19 least least JJS cord-010119-t1x9gknd 3485 20 2 2 CD cord-010119-t1x9gknd 3485 21 weeks week NNS cord-010119-t1x9gknd 3485 22 of of IN cord-010119-t1x9gknd 3485 23 storage storage NN cord-010119-t1x9gknd 3485 24 at at IN cord-010119-t1x9gknd 3485 25 48C 48c CD cord-010119-t1x9gknd 3485 26 without without IN cord-010119-t1x9gknd 3485 27 agitation agitation NN cord-010119-t1x9gknd 3485 28 . . . cord-010119-t1x9gknd 3486 1 It -PRON- PRP cord-010119-t1x9gknd 3486 2 may may MD cord-010119-t1x9gknd 3486 3 be be VB cord-010119-t1x9gknd 3486 4 possible possible JJ cord-010119-t1x9gknd 3486 5 to to TO cord-010119-t1x9gknd 3486 6 extend extend VB cord-010119-t1x9gknd 3486 7 the the DT cord-010119-t1x9gknd 3486 8 preservation preservation NN cord-010119-t1x9gknd 3486 9 of of IN cord-010119-t1x9gknd 3486 10 platelet platelet NN cord-010119-t1x9gknd 3486 11 function function NN cord-010119-t1x9gknd 3486 12 by by IN cord-010119-t1x9gknd 3486 13 agitating agitate VBG cord-010119-t1x9gknd 3486 14 WB WB NNP cord-010119-t1x9gknd 3486 15 . . . cord-010119-t1x9gknd 3487 1 In in IN cord-010119-t1x9gknd 3487 2 order order NN cord-010119-t1x9gknd 3487 3 to to TO cord-010119-t1x9gknd 3487 4 more more RBR cord-010119-t1x9gknd 3487 5 fully fully RB cord-010119-t1x9gknd 3487 6 characterize characterize VB cord-010119-t1x9gknd 3487 7 the the DT cord-010119-t1x9gknd 3487 8 quality quality NN cord-010119-t1x9gknd 3487 9 of of IN cord-010119-t1x9gknd 3487 10 WB WB NNP cord-010119-t1x9gknd 3487 11 stored store VBN cord-010119-t1x9gknd 3487 12 at at IN cord-010119-t1x9gknd 3487 13 48C 48c CD cord-010119-t1x9gknd 3487 14 with with IN cord-010119-t1x9gknd 3487 15 or or CC cord-010119-t1x9gknd 3487 16 without without IN cord-010119-t1x9gknd 3487 17 agitation agitation NN cord-010119-t1x9gknd 3487 18 , , , cord-010119-t1x9gknd 3487 19 we -PRON- PRP cord-010119-t1x9gknd 3487 20 evaluated evaluate VBD cord-010119-t1x9gknd 3487 21 complement complement JJ cord-010119-t1x9gknd 3487 22 activation activation NN cord-010119-t1x9gknd 3487 23 as as IN cord-010119-t1x9gknd 3487 24 a a DT cord-010119-t1x9gknd 3487 25 marker marker NN cord-010119-t1x9gknd 3487 26 of of IN cord-010119-t1x9gknd 3487 27 inflammatory inflammatory JJ cord-010119-t1x9gknd 3487 28 potential potential NN cord-010119-t1x9gknd 3487 29 . . . cord-010119-t1x9gknd 3488 1 Study Study NNP cord-010119-t1x9gknd 3488 2 Design Design NNP cord-010119-t1x9gknd 3488 3 / / SYM cord-010119-t1x9gknd 3488 4 Method method NN cord-010119-t1x9gknd 3488 5 : : : cord-010119-t1x9gknd 3489 1 Subjects subject NNS cord-010119-t1x9gknd 3489 2 donated donate VBD cord-010119-t1x9gknd 3489 3 one one CD cord-010119-t1x9gknd 3489 4 unit unit NN cord-010119-t1x9gknd 3489 5 of of IN cord-010119-t1x9gknd 3489 6 WB WB NNP cord-010119-t1x9gknd 3489 7 collected collect VBN cord-010119-t1x9gknd 3489 8 in in IN cord-010119-t1x9gknd 3489 9 CPD CPD NNP cord-010119-t1x9gknd 3489 10 - - HYPH cord-010119-t1x9gknd 3489 11 A2 A2 NNP cord-010119-t1x9gknd 3489 12 ( ( -LRB- cord-010119-t1x9gknd 3489 13 citrate citrate NN cord-010119-t1x9gknd 3489 14 phosphate phosphate NN cord-010119-t1x9gknd 3489 15 dextrose dextrose NN cord-010119-t1x9gknd 3489 16 anticoagulant anticoagulant NN cord-010119-t1x9gknd 3489 17 with with IN cord-010119-t1x9gknd 3489 18 adenine adenine NN cord-010119-t1x9gknd 3489 19 ) ) -RRB- cord-010119-t1x9gknd 3489 20 . . . cord-010119-t1x9gknd 3490 1 The the DT cord-010119-t1x9gknd 3490 2 WB WB NNP cord-010119-t1x9gknd 3490 3 was be VBD cord-010119-t1x9gknd 3490 4 not not RB cord-010119-t1x9gknd 3490 5 leukoreduced leukoreduce VBN cord-010119-t1x9gknd 3490 6 nor nor CC cord-010119-t1x9gknd 3490 7 was be VBD cord-010119-t1x9gknd 3490 8 it -PRON- PRP cord-010119-t1x9gknd 3490 9 separated separate VBN cord-010119-t1x9gknd 3490 10 into into IN cord-010119-t1x9gknd 3490 11 components component NNS cord-010119-t1x9gknd 3490 12 . . . cord-010119-t1x9gknd 3491 1 Units unit NNS cord-010119-t1x9gknd 3491 2 were be VBD cord-010119-t1x9gknd 3491 3 stored store VBN cord-010119-t1x9gknd 3491 4 under under IN cord-010119-t1x9gknd 3491 5 refrigerated refrigerated JJ cord-010119-t1x9gknd 3491 6 conditions condition NNS cord-010119-t1x9gknd 3491 7 for for IN cord-010119-t1x9gknd 3491 8 10 10 CD cord-010119-t1x9gknd 3491 9 , , , cord-010119-t1x9gknd 3491 10 12 12 CD cord-010119-t1x9gknd 3491 11 , , , cord-010119-t1x9gknd 3491 12 15 15 CD cord-010119-t1x9gknd 3491 13 , , , cord-010119-t1x9gknd 3491 14 or or CC cord-010119-t1x9gknd 3491 15 22 22 CD cord-010119-t1x9gknd 3491 16 days day NNS cord-010119-t1x9gknd 3491 17 after after IN cord-010119-t1x9gknd 3491 18 collection collection NN cord-010119-t1x9gknd 3491 19 . . . cord-010119-t1x9gknd 3492 1 Units unit NNS cord-010119-t1x9gknd 3492 2 were be VBD cord-010119-t1x9gknd 3492 3 stored store VBN cord-010119-t1x9gknd 3492 4 for for IN cord-010119-t1x9gknd 3492 5 12 12 CD cord-010119-t1x9gknd 3492 6 days day NNS cord-010119-t1x9gknd 3492 7 without without IN cord-010119-t1x9gknd 3492 8 agitation agitation NN cord-010119-t1x9gknd 3492 9 . . . cord-010119-t1x9gknd 3493 1 Units unit NNS cord-010119-t1x9gknd 3493 2 stored store VBN cord-010119-t1x9gknd 3493 3 for for IN cord-010119-t1x9gknd 3493 4 10 10 CD cord-010119-t1x9gknd 3493 5 , , , cord-010119-t1x9gknd 3493 6 15 15 CD cord-010119-t1x9gknd 3493 7 or or CC cord-010119-t1x9gknd 3493 8 22 22 CD cord-010119-t1x9gknd 3493 9 days day NNS cord-010119-t1x9gknd 3493 10 were be VBD cord-010119-t1x9gknd 3493 11 agitated agitate VBN cord-010119-t1x9gknd 3493 12 during during IN cord-010119-t1x9gknd 3493 13 storage storage NN cord-010119-t1x9gknd 3493 14 with with IN cord-010119-t1x9gknd 3493 15 a a DT cord-010119-t1x9gknd 3493 16 Model Model NNP cord-010119-t1x9gknd 3493 17 400 400 CD cord-010119-t1x9gknd 3493 18 Hybridization hybridization NN cord-010119-t1x9gknd 3493 19 Incubator Incubator NNP cord-010119-t1x9gknd 3493 20 at at IN cord-010119-t1x9gknd 3493 21 48C 48c CD cord-010119-t1x9gknd 3493 22 set set NN cord-010119-t1x9gknd 3493 23 for for IN cord-010119-t1x9gknd 3493 24 end end NN cord-010119-t1x9gknd 3493 25 over over IN cord-010119-t1x9gknd 3493 26 end end NN cord-010119-t1x9gknd 3493 27 rotation rotation NN cord-010119-t1x9gknd 3493 28 at at IN cord-010119-t1x9gknd 3493 29 2 2 CD cord-010119-t1x9gknd 3493 30 - - SYM cord-010119-t1x9gknd 3493 31 3 3 CD cord-010119-t1x9gknd 3493 32 rpms rpms NN cord-010119-t1x9gknd 3493 33 . . . cord-010119-t1x9gknd 3494 1 At at IN cord-010119-t1x9gknd 3494 2 the the DT cord-010119-t1x9gknd 3494 3 appropriate appropriate JJ cord-010119-t1x9gknd 3494 4 time time NN cord-010119-t1x9gknd 3494 5 point point NN cord-010119-t1x9gknd 3494 6 , , , cord-010119-t1x9gknd 3494 7 platelet platelet NN cord-010119-t1x9gknd 3494 8 free free JJ cord-010119-t1x9gknd 3494 9 plasma plasma NN cord-010119-t1x9gknd 3494 10 was be VBD cord-010119-t1x9gknd 3494 11 obtained obtain VBN cord-010119-t1x9gknd 3494 12 from from IN cord-010119-t1x9gknd 3494 13 the the DT cord-010119-t1x9gknd 3494 14 WB WB NNP cord-010119-t1x9gknd 3494 15 sample sample NN cord-010119-t1x9gknd 3494 16 and and CC cord-010119-t1x9gknd 3494 17 stored store VBN cord-010119-t1x9gknd 3494 18 at at IN cord-010119-t1x9gknd 3494 19 -808C. -808C. . cord-010119-t1x9gknd 3495 1 The the DT cord-010119-t1x9gknd 3495 2 frozen frozen JJ cord-010119-t1x9gknd 3495 3 plasma plasma NN cord-010119-t1x9gknd 3495 4 was be VBD cord-010119-t1x9gknd 3495 5 analyzed analyze VBN cord-010119-t1x9gknd 3495 6 by by IN cord-010119-t1x9gknd 3495 7 ELISA ELISA NNP cord-010119-t1x9gknd 3495 8 assays assay NNS cord-010119-t1x9gknd 3495 9 to to TO cord-010119-t1x9gknd 3495 10 determine determine VB cord-010119-t1x9gknd 3495 11 : : : cord-010119-t1x9gknd 3495 12 thrombinantithrombin thrombinantithrombin NNP cord-010119-t1x9gknd 3495 13 complex complex NNP cord-010119-t1x9gknd 3495 14 ( ( -LRB- cord-010119-t1x9gknd 3495 15 TAT tat NN cord-010119-t1x9gknd 3495 16 ) ) -RRB- cord-010119-t1x9gknd 3495 17 as as IN cord-010119-t1x9gknd 3495 18 a a DT cord-010119-t1x9gknd 3495 19 marker marker NN cord-010119-t1x9gknd 3495 20 of of IN cord-010119-t1x9gknd 3495 21 coagulation coagulation NN cord-010119-t1x9gknd 3495 22 ; ; : cord-010119-t1x9gknd 3495 23 soluble soluble JJ cord-010119-t1x9gknd 3495 24 CD40L cd40l NN cord-010119-t1x9gknd 3495 25 as as IN cord-010119-t1x9gknd 3495 26 a a DT cord-010119-t1x9gknd 3495 27 measure measure NN cord-010119-t1x9gknd 3495 28 of of IN cord-010119-t1x9gknd 3495 29 platelet platelet NN cord-010119-t1x9gknd 3495 30 activation activation NN cord-010119-t1x9gknd 3495 31 and and CC cord-010119-t1x9gknd 3495 32 granule granule NN cord-010119-t1x9gknd 3495 33 release release NN cord-010119-t1x9gknd 3495 34 ; ; : cord-010119-t1x9gknd 3495 35 plasmin plasmin NNP cord-010119-t1x9gknd 3495 36 anti anti JJ cord-010119-t1x9gknd 3495 37 - - JJ cord-010119-t1x9gknd 3495 38 plasmin plasmin JJ cord-010119-t1x9gknd 3495 39 complex complex NN cord-010119-t1x9gknd 3495 40 ( ( -LRB- cord-010119-t1x9gknd 3495 41 PAP pap NN cord-010119-t1x9gknd 3495 42 ) ) -RRB- cord-010119-t1x9gknd 3495 43 as as IN cord-010119-t1x9gknd 3495 44 a a DT cord-010119-t1x9gknd 3495 45 marker marker NN cord-010119-t1x9gknd 3495 46 of of IN cord-010119-t1x9gknd 3495 47 fibrinolysis fibrinolysis NN cord-010119-t1x9gknd 3495 48 ; ; : cord-010119-t1x9gknd 3495 49 plasminogen plasminogen NN cord-010119-t1x9gknd 3495 50 activator activator NN cord-010119-t1x9gknd 3495 51 inhibitor inhibitor NN cord-010119-t1x9gknd 3495 52 ( ( -LRB- cord-010119-t1x9gknd 3495 53 PAI-1 PAI-1 NNP cord-010119-t1x9gknd 3495 54 ) ) -RRB- cord-010119-t1x9gknd 3495 55 as as IN cord-010119-t1x9gknd 3495 56 another another DT cord-010119-t1x9gknd 3495 57 fibrinolytic fibrinolytic JJ cord-010119-t1x9gknd 3495 58 measure measure NN cord-010119-t1x9gknd 3495 59 ; ; : cord-010119-t1x9gknd 3495 60 and and CC cord-010119-t1x9gknd 3495 61 complement complement VB cord-010119-t1x9gknd 3495 62 activation activation NN cord-010119-t1x9gknd 3495 63 markers marker NNS cord-010119-t1x9gknd 3495 64 C3a C3a NNP cord-010119-t1x9gknd 3495 65 , , , cord-010119-t1x9gknd 3495 66 C4d C4d NNP cord-010119-t1x9gknd 3495 67 , , , cord-010119-t1x9gknd 3495 68 C5a C5a NNS cord-010119-t1x9gknd 3495 69 and and CC cord-010119-t1x9gknd 3495 70 C5b-9 c5b-9 NN cord-010119-t1x9gknd 3495 71 . . . cord-010119-t1x9gknd 3496 1 Data datum NNS cord-010119-t1x9gknd 3496 2 was be VBD cord-010119-t1x9gknd 3496 3 analyzed analyze VBN cord-010119-t1x9gknd 3496 4 by by IN cord-010119-t1x9gknd 3496 5 one one CD cord-010119-t1x9gknd 3496 6 way way NN cord-010119-t1x9gknd 3496 7 repeated repeat VBN cord-010119-t1x9gknd 3496 8 measure measure NN cord-010119-t1x9gknd 3496 9 ANOVA ANOVA NNP cord-010119-t1x9gknd 3496 10 . . . cord-010119-t1x9gknd 3497 1 Results/ Results/ . cord-010119-t1x9gknd 3498 1 Finding finding NN cord-010119-t1x9gknd 3498 2 : : : cord-010119-t1x9gknd 3498 3 Only only RB cord-010119-t1x9gknd 3498 4 49 49 CD cord-010119-t1x9gknd 3498 5 6 6 CD cord-010119-t1x9gknd 3498 6 12 12 CD cord-010119-t1x9gknd 3498 7 % % NN cord-010119-t1x9gknd 3498 8 of of IN cord-010119-t1x9gknd 3498 9 the the DT cord-010119-t1x9gknd 3498 10 platelets platelet NNS cord-010119-t1x9gknd 3498 11 were be VBD cord-010119-t1x9gknd 3498 12 recovered recover VBN cord-010119-t1x9gknd 3498 13 in in IN cord-010119-t1x9gknd 3498 14 units unit NNS cord-010119-t1x9gknd 3498 15 stored store VBN cord-010119-t1x9gknd 3498 16 for for IN cord-010119-t1x9gknd 3498 17 12 12 CD cord-010119-t1x9gknd 3498 18 days day NNS cord-010119-t1x9gknd 3498 19 without without IN cord-010119-t1x9gknd 3498 20 agitation agitation NN cord-010119-t1x9gknd 3498 21 . . . cord-010119-t1x9gknd 3499 1 These these DT cord-010119-t1x9gknd 3499 2 levels level NNS cord-010119-t1x9gknd 3499 3 did do VBD cord-010119-t1x9gknd 3499 4 not not RB cord-010119-t1x9gknd 3499 5 meet meet VB cord-010119-t1x9gknd 3499 6 FDA FDA NNP cord-010119-t1x9gknd 3499 7 requirements requirement NNS cord-010119-t1x9gknd 3499 8 of of IN cord-010119-t1x9gknd 3499 9 5.5 5.5 CD cord-010119-t1x9gknd 3499 10 x x SYM cord-010119-t1x9gknd 3499 11 10 10 CD cord-010119-t1x9gknd 3499 12 10 10 CD cord-010119-t1x9gknd 3499 13 platelets platelet NNS cord-010119-t1x9gknd 3499 14 per per IN cord-010119-t1x9gknd 3499 15 WB WB NNP cord-010119-t1x9gknd 3499 16 unit unit NN cord-010119-t1x9gknd 3499 17 . . . cord-010119-t1x9gknd 3500 1 Subsequently subsequently RB cord-010119-t1x9gknd 3500 2 , , , cord-010119-t1x9gknd 3500 3 WB WB NNP cord-010119-t1x9gknd 3500 4 was be VBD cord-010119-t1x9gknd 3500 5 agitated agitated JJ cord-010119-t1x9gknd 3500 6 and and CC cord-010119-t1x9gknd 3500 7 platelet platelet NN cord-010119-t1x9gknd 3500 8 recovery recovery NN cord-010119-t1x9gknd 3500 9 was be VBD cord-010119-t1x9gknd 3500 10 71 71 CD cord-010119-t1x9gknd 3500 11 - - SYM cord-010119-t1x9gknd 3500 12 76 76 CD cord-010119-t1x9gknd 3500 13 % % NN cord-010119-t1x9gknd 3500 14 . . . cord-010119-t1x9gknd 3501 1 No no DT cord-010119-t1x9gknd 3501 2 difference difference NN cord-010119-t1x9gknd 3501 3 was be VBD cord-010119-t1x9gknd 3501 4 seen see VBN cord-010119-t1x9gknd 3501 5 in in IN cord-010119-t1x9gknd 3501 6 ELISA ELISA NNP cord-010119-t1x9gknd 3501 7 analysis analysis NN cord-010119-t1x9gknd 3501 8 for for IN cord-010119-t1x9gknd 3501 9 agitated agitated JJ cord-010119-t1x9gknd 3501 10 or or CC cord-010119-t1x9gknd 3501 11 non non JJ cord-010119-t1x9gknd 3501 12 - - JJ cord-010119-t1x9gknd 3501 13 agitated agitated JJ cord-010119-t1x9gknd 3501 14 samples sample NNS cord-010119-t1x9gknd 3501 15 . . . cord-010119-t1x9gknd 3502 1 No no DT cord-010119-t1x9gknd 3502 2 change change NN cord-010119-t1x9gknd 3502 3 was be VBD cord-010119-t1x9gknd 3502 4 seen see VBN cord-010119-t1x9gknd 3502 5 in in IN cord-010119-t1x9gknd 3502 6 TAT tat NN cord-010119-t1x9gknd 3502 7 or or CC cord-010119-t1x9gknd 3502 8 PAP pap NN cord-010119-t1x9gknd 3502 9 levels level NNS cord-010119-t1x9gknd 3502 10 between between IN cord-010119-t1x9gknd 3502 11 T0 T0 NNP cord-010119-t1x9gknd 3502 12 ( ( -LRB- cord-010119-t1x9gknd 3502 13 day day NN cord-010119-t1x9gknd 3502 14 of of IN cord-010119-t1x9gknd 3502 15 collection collection NN cord-010119-t1x9gknd 3502 16 ) ) -RRB- cord-010119-t1x9gknd 3502 17 and and CC cord-010119-t1x9gknd 3502 18 T10 T10 NNP cord-010119-t1x9gknd 3502 19 , , , cord-010119-t1x9gknd 3502 20 12 12 CD cord-010119-t1x9gknd 3502 21 , , , cord-010119-t1x9gknd 3502 22 15 15 CD cord-010119-t1x9gknd 3502 23 , , , cord-010119-t1x9gknd 3502 24 or or CC cord-010119-t1x9gknd 3502 25 22 22 CD cord-010119-t1x9gknd 3502 26 measurements measurement NNS cord-010119-t1x9gknd 3502 27 . . . cord-010119-t1x9gknd 3503 1 Significant significant JJ cord-010119-t1x9gknd 3503 2 elevations elevation NNS cord-010119-t1x9gknd 3503 3 of of IN cord-010119-t1x9gknd 3503 4 PAI-1 PAI-1 NNP cord-010119-t1x9gknd 3503 5 and and CC cord-010119-t1x9gknd 3503 6 sCD40L sCD40L NNP cord-010119-t1x9gknd 3503 7 indicate indicate VBP cord-010119-t1x9gknd 3503 8 activation activation NN cord-010119-t1x9gknd 3503 9 of of IN cord-010119-t1x9gknd 3503 10 platelets platelet NNS cord-010119-t1x9gknd 3503 11 and and CC cord-010119-t1x9gknd 3503 12 inhibition inhibition NN cord-010119-t1x9gknd 3503 13 of of IN cord-010119-t1x9gknd 3503 14 fibrinolysis fibrinolysis NN cord-010119-t1x9gknd 3503 15 ( ( -LRB- cord-010119-t1x9gknd 3503 16 p<0.001 p<0.001 CD cord-010119-t1x9gknd 3503 17 ) ) -RRB- cord-010119-t1x9gknd 3503 18 . . . cord-010119-t1x9gknd 3504 1 Activated activate VBN cord-010119-t1x9gknd 3504 2 complement complement NN cord-010119-t1x9gknd 3504 3 peptides peptide NNS cord-010119-t1x9gknd 3504 4 C3a C3a NNP cord-010119-t1x9gknd 3504 5 , , , cord-010119-t1x9gknd 3504 6 C5a C5a NNS cord-010119-t1x9gknd 3504 7 , , , cord-010119-t1x9gknd 3504 8 and and CC cord-010119-t1x9gknd 3504 9 C4d C4d NNP cord-010119-t1x9gknd 3504 10 were be VBD cord-010119-t1x9gknd 3504 11 all all DT cord-010119-t1x9gknd 3504 12 elevated elevate VBN cord-010119-t1x9gknd 3504 13 over over IN cord-010119-t1x9gknd 3504 14 time time NN cord-010119-t1x9gknd 3504 15 ( ( -LRB- cord-010119-t1x9gknd 3504 16 p<0.001 p<0.001 NNS cord-010119-t1x9gknd 3504 17 ) ) -RRB- cord-010119-t1x9gknd 3504 18 while while IN cord-010119-t1x9gknd 3504 19 sC5d-9 sC5d-9 NNP cord-010119-t1x9gknd 3504 20 was be VBD cord-010119-t1x9gknd 3504 21 not not RB cord-010119-t1x9gknd 3504 22 . . . cord-010119-t1x9gknd 3505 1 However however RB cord-010119-t1x9gknd 3505 2 , , , cord-010119-t1x9gknd 3505 3 only only RB cord-010119-t1x9gknd 3505 4 C3a C3a NNP cord-010119-t1x9gknd 3505 5 and and CC cord-010119-t1x9gknd 3505 6 C4d C4d NNP cord-010119-t1x9gknd 3505 7 levels level NNS cord-010119-t1x9gknd 3505 8 at at IN cord-010119-t1x9gknd 3505 9 T22 T22 NNP cord-010119-t1x9gknd 3505 10 were be VBD cord-010119-t1x9gknd 3505 11 above above IN cord-010119-t1x9gknd 3505 12 normal normal JJ cord-010119-t1x9gknd 3505 13 reference reference NN cord-010119-t1x9gknd 3505 14 ranges range VBZ cord-010119-t1x9gknd 3505 15 at at IN cord-010119-t1x9gknd 3505 16 1.30 1.30 CD cord-010119-t1x9gknd 3505 17 and and CC cord-010119-t1x9gknd 3505 18 1.41 1.41 CD cord-010119-t1x9gknd 3505 19 times time NNS cord-010119-t1x9gknd 3505 20 maximum maximum JJ cord-010119-t1x9gknd 3505 21 reference reference NN cord-010119-t1x9gknd 3505 22 , , , cord-010119-t1x9gknd 3505 23 respectively respectively RB cord-010119-t1x9gknd 3505 24 . . . cord-010119-t1x9gknd 3506 1 Conclusion conclusion NN cord-010119-t1x9gknd 3506 2 : : : cord-010119-t1x9gknd 3507 1 Whole whole JJ cord-010119-t1x9gknd 3507 2 blood blood NN cord-010119-t1x9gknd 3507 3 agitation agitation NN cord-010119-t1x9gknd 3507 4 appeared appear VBD cord-010119-t1x9gknd 3507 5 necessary necessary JJ cord-010119-t1x9gknd 3507 6 to to TO cord-010119-t1x9gknd 3507 7 recover recover VB cord-010119-t1x9gknd 3507 8 platelets platelet NNS cord-010119-t1x9gknd 3507 9 at at IN cord-010119-t1x9gknd 3507 10 or or CC cord-010119-t1x9gknd 3507 11 above above IN cord-010119-t1x9gknd 3507 12 FDA FDA NNP cord-010119-t1x9gknd 3507 13 requirements requirement NNS cord-010119-t1x9gknd 3507 14 . . . cord-010119-t1x9gknd 3508 1 Whole whole JJ cord-010119-t1x9gknd 3508 2 blood blood NN cord-010119-t1x9gknd 3508 3 stored store VBN cord-010119-t1x9gknd 3508 4 at at IN cord-010119-t1x9gknd 3508 5 48C 48c CD cord-010119-t1x9gknd 3508 6 for for IN cord-010119-t1x9gknd 3508 7 10 10 CD cord-010119-t1x9gknd 3508 8 - - SYM cord-010119-t1x9gknd 3508 9 22 22 CD cord-010119-t1x9gknd 3508 10 days day NNS cord-010119-t1x9gknd 3508 11 did do VBD cord-010119-t1x9gknd 3508 12 show show VB cord-010119-t1x9gknd 3508 13 some some DT cord-010119-t1x9gknd 3508 14 activation activation NN cord-010119-t1x9gknd 3508 15 of of IN cord-010119-t1x9gknd 3508 16 complement complement NN cord-010119-t1x9gknd 3508 17 proteins protein NNS cord-010119-t1x9gknd 3508 18 . . . cord-010119-t1x9gknd 3509 1 In in IN cord-010119-t1x9gknd 3509 2 contrast contrast NN cord-010119-t1x9gknd 3509 3 to to IN cord-010119-t1x9gknd 3509 4 studies study NNS cord-010119-t1x9gknd 3509 5 in in IN cord-010119-t1x9gknd 3509 6 stored store VBN cord-010119-t1x9gknd 3509 7 red red JJ cord-010119-t1x9gknd 3509 8 blood blood NN cord-010119-t1x9gknd 3509 9 cells cell NNS cord-010119-t1x9gknd 3509 10 with with IN cord-010119-t1x9gknd 3509 11 elevations elevation NNS cord-010119-t1x9gknd 3509 12 of of IN cord-010119-t1x9gknd 3509 13 sC5d-9 sc5d-9 NN cord-010119-t1x9gknd 3509 14 reported report VBN cord-010119-t1x9gknd 3509 15 , , , cord-010119-t1x9gknd 3509 16 WB WB NNP cord-010119-t1x9gknd 3509 17 showed show VBD cord-010119-t1x9gknd 3509 18 elevation elevation NN cord-010119-t1x9gknd 3509 19 of of IN cord-010119-t1x9gknd 3509 20 C3a C3a NNP cord-010119-t1x9gknd 3509 21 , , , cord-010119-t1x9gknd 3509 22 5a 5a CD cord-010119-t1x9gknd 3509 23 and and CC cord-010119-t1x9gknd 3509 24 C4d C4d NNP cord-010119-t1x9gknd 3509 25 and and CC cord-010119-t1x9gknd 3509 26 not not RB cord-010119-t1x9gknd 3509 27 sC5d-9 sC5d-9 NNP cord-010119-t1x9gknd 3509 28 . . . cord-010119-t1x9gknd 3510 1 Complement complement NN cord-010119-t1x9gknd 3510 2 was be VBD cord-010119-t1x9gknd 3510 3 gradually gradually RB cord-010119-t1x9gknd 3510 4 and and CC cord-010119-t1x9gknd 3510 5 modestly modestly RB cord-010119-t1x9gknd 3510 6 activated activate VBN cord-010119-t1x9gknd 3510 7 with with IN cord-010119-t1x9gknd 3510 8 most most JJS cord-010119-t1x9gknd 3510 9 levels level NNS cord-010119-t1x9gknd 3510 10 remaining remain VBG cord-010119-t1x9gknd 3510 11 within within IN cord-010119-t1x9gknd 3510 12 reference reference NN cord-010119-t1x9gknd 3510 13 ranges range VBZ cord-010119-t1x9gknd 3510 14 over over IN cord-010119-t1x9gknd 3510 15 whole whole JJ cord-010119-t1x9gknd 3510 16 blood blood NN cord-010119-t1x9gknd 3510 17 shelf shelf NN cord-010119-t1x9gknd 3510 18 life life NN cord-010119-t1x9gknd 3510 19 . . . cord-010119-t1x9gknd 3511 1 Meredith Meredith NNP cord-010119-t1x9gknd 3511 2 Lummer Lummer NNP cord-010119-t1x9gknd 3511 3 * * NFP cord-010119-t1x9gknd 3511 4 1 1 CD cord-010119-t1x9gknd 3511 5 and and CC cord-010119-t1x9gknd 3511 6 Christian Christian NNP cord-010119-t1x9gknd 3511 7 Todd Todd NNP cord-010119-t1x9gknd 3511 8 2 2 CD cord-010119-t1x9gknd 3511 9 . . . cord-010119-t1x9gknd 3512 1 1 1 CD cord-010119-t1x9gknd 3512 2 Cerus Cerus NNP cord-010119-t1x9gknd 3512 3 Corporation Corporation NNP cord-010119-t1x9gknd 3512 4 , , , cord-010119-t1x9gknd 3512 5 2 2 CD cord-010119-t1x9gknd 3512 6 Community Community NNP cord-010119-t1x9gknd 3512 7 Blood Blood NNP cord-010119-t1x9gknd 3512 8 Serivces Serivces NNPS cord-010119-t1x9gknd 3512 9 Background Background NNP cord-010119-t1x9gknd 3512 10 / / SYM cord-010119-t1x9gknd 3512 11 Case Case NNP cord-010119-t1x9gknd 3512 12 Studies Studies NNPS cord-010119-t1x9gknd 3512 13 : : : cord-010119-t1x9gknd 3513 1 The the DT cord-010119-t1x9gknd 3513 2 INTERCEPTV INTERCEPTV NNP cord-010119-t1x9gknd 3513 3 R r NN cord-010119-t1x9gknd 3513 4 Blood blood NN cord-010119-t1x9gknd 3513 5 System system NN cord-010119-t1x9gknd 3513 6 for for IN cord-010119-t1x9gknd 3513 7 Platelets platelet NNS cord-010119-t1x9gknd 3513 8 ( ( -LRB- cord-010119-t1x9gknd 3513 9 Cerus Cerus NNP cord-010119-t1x9gknd 3513 10 , , , cord-010119-t1x9gknd 3513 11 Concord Concord NNP cord-010119-t1x9gknd 3513 12 CA CA NNP cord-010119-t1x9gknd 3513 13 ) ) -RRB- cord-010119-t1x9gknd 3513 14 is be VBZ cord-010119-t1x9gknd 3513 15 used use VBN cord-010119-t1x9gknd 3513 16 for for IN cord-010119-t1x9gknd 3513 17 the the DT cord-010119-t1x9gknd 3513 18 pathogen pathogen NN cord-010119-t1x9gknd 3513 19 reduction reduction NN cord-010119-t1x9gknd 3513 20 ( ( -LRB- cord-010119-t1x9gknd 3513 21 PR PR NNP cord-010119-t1x9gknd 3513 22 ) ) -RRB- cord-010119-t1x9gknd 3513 23 of of IN cord-010119-t1x9gknd 3513 24 platelet platelet NN cord-010119-t1x9gknd 3513 25 collections collection NNS cord-010119-t1x9gknd 3513 26 , , , cord-010119-t1x9gknd 3513 27 and and CC cord-010119-t1x9gknd 3513 28 replaces replace VBZ cord-010119-t1x9gknd 3513 29 irradiation irradiation NN cord-010119-t1x9gknd 3513 30 , , , cord-010119-t1x9gknd 3513 31 CMV CMV NNP cord-010119-t1x9gknd 3513 32 testing testing NN cord-010119-t1x9gknd 3513 33 , , , cord-010119-t1x9gknd 3513 34 bacterial bacterial JJ cord-010119-t1x9gknd 3513 35 culture culture NN cord-010119-t1x9gknd 3513 36 and and CC cord-010119-t1x9gknd 3513 37 point point NN cord-010119-t1x9gknd 3513 38 of of IN cord-010119-t1x9gknd 3513 39 issue issue NN cord-010119-t1x9gknd 3513 40 bacterial bacterial JJ cord-010119-t1x9gknd 3513 41 testing testing NN cord-010119-t1x9gknd 3513 42 . . . cord-010119-t1x9gknd 3514 1 To to TO cord-010119-t1x9gknd 3514 2 better well RBR cord-010119-t1x9gknd 3514 3 understand understand VB cord-010119-t1x9gknd 3514 4 PR PR NNP cord-010119-t1x9gknd 3514 5 compatibility compatibility NN cord-010119-t1x9gknd 3514 6 and and CC cord-010119-t1x9gknd 3514 7 impact impact NN cord-010119-t1x9gknd 3514 8 to to IN cord-010119-t1x9gknd 3514 9 split split JJ cord-010119-t1x9gknd 3514 10 rate rate NN cord-010119-t1x9gknd 3514 11 , , , cord-010119-t1x9gknd 3514 12 data datum NNS cord-010119-t1x9gknd 3514 13 were be VBD cord-010119-t1x9gknd 3514 14 analyzed analyze VBN cord-010119-t1x9gknd 3514 15 from from IN cord-010119-t1x9gknd 3514 16 a a DT cord-010119-t1x9gknd 3514 17 mid mid JJ cord-010119-t1x9gknd 3514 18 - - NN cord-010119-t1x9gknd 3514 19 size size NN cord-010119-t1x9gknd 3514 20 blood blood NN cord-010119-t1x9gknd 3514 21 center center NN cord-010119-t1x9gknd 3514 22 with with IN cord-010119-t1x9gknd 3514 23 roughly roughly RB cord-010119-t1x9gknd 3514 24 1.1x10 1.1x10 CD cord-010119-t1x9gknd 3514 25 10 10 CD cord-010119-t1x9gknd 3514 26 6 6 CD cord-010119-t1x9gknd 3514 27 5.6x10 5.6x10 CD cord-010119-t1x9gknd 3514 28 9 9 CD cord-010119-t1x9gknd 3514 29 9.8x10 9.8x10 CD cord-010119-t1x9gknd 3514 30 10 10 CD cord-010119-t1x9gknd 3514 31 6 6 CD cord-010119-t1x9gknd 3514 32 5.6x10 5.6x10 CD cord-010119-t1x9gknd 3514 33 10 10 CD cord-010119-t1x9gknd 3514 34 310 310 CD cord-010119-t1x9gknd 3514 35 6 6 CD cord-010119-t1x9gknd 3514 36 330 330 CD cord-010119-t1x9gknd 3514 37 430 430 CD cord-010119-t1x9gknd 3514 38 6 6 CD cord-010119-t1x9gknd 3514 39 440 440 CD cord-010119-t1x9gknd 3514 40 900 900 CD cord-010119-t1x9gknd 3514 41 6 6 CD cord-010119-t1x9gknd 3514 42 260 260 CD cord-010119-t1x9gknd 3514 43 28000 28000 CD cord-010119-t1x9gknd 3514 44 6 6 CD cord-010119-t1x9gknd 3514 45 33000 33000 CD cord-010119-t1x9gknd 3514 46 3 3 CD cord-010119-t1x9gknd 3514 47 6 6 CD cord-010119-t1x9gknd 3514 48 3 3 CD cord-010119-t1x9gknd 3514 49 186 186 CD cord-010119-t1x9gknd 3514 50 31 31 CD cord-010119-t1x9gknd 3514 51 30 30 CD cord-010119-t1x9gknd 3514 52 6 6 CD cord-010119-t1x9gknd 3514 53 22 22 CD cord-010119-t1x9gknd 3514 54 110 110 CD cord-010119-t1x9gknd 3514 55 6 6 CD cord-010119-t1x9gknd 3514 56 97 97 CD cord-010119-t1x9gknd 3514 57 RCF RCF NNP cord-010119-t1x9gknd 3514 58 1.9x10 1.9x10 CD cord-010119-t1x9gknd 3514 59 10 10 CD cord-010119-t1x9gknd 3514 60 6 6 CD cord-010119-t1x9gknd 3514 61 7.4x10 7.4x10 CD cord-010119-t1x9gknd 3514 62 9 9 CD cord-010119-t1x9gknd 3514 63 4.2x10 4.2x10 CD cord-010119-t1x9gknd 3514 64 10 10 CD cord-010119-t1x9gknd 3514 65 6 6 CD cord-010119-t1x9gknd 3514 66 1.1x10 1.1x10 CD cord-010119-t1x9gknd 3514 67 10 10 CD cord-010119-t1x9gknd 3514 68 13 13 CD cord-010119-t1x9gknd 3514 69 6 6 CD cord-010119-t1x9gknd 3514 70 4 4 CD cord-010119-t1x9gknd 3514 71 316 316 CD cord-010119-t1x9gknd 3514 72 14 14 CD cord-010119-t1x9gknd 3514 73 530 530 CD cord-010119-t1x9gknd 3514 74 6 6 CD cord-010119-t1x9gknd 3514 75 160 160 CD cord-010119-t1x9gknd 3514 76 5100 5100 CD cord-010119-t1x9gknd 3514 77 6 6 CD cord-010119-t1x9gknd 3514 78 2000 2000 CD cord-010119-t1x9gknd 3514 79 3 3 CD cord-010119-t1x9gknd 3514 80 6 6 CD cord-010119-t1x9gknd 3514 81 3 3 CD cord-010119-t1x9gknd 3514 82 96 96 CD cord-010119-t1x9gknd 3514 83 7 7 CD cord-010119-t1x9gknd 3514 84 176 176 CD cord-010119-t1x9gknd 3514 85 7 7 CD cord-010119-t1x9gknd 3514 86 346 346 CD cord-010119-t1x9gknd 3514 87 11 11 CD cord-010119-t1x9gknd 3514 88 Apheresis Apheresis NNP cord-010119-t1x9gknd 3514 89 2.4x10 2.4x10 CD cord-010119-t1x9gknd 3514 90 10 10 CD cord-010119-t1x9gknd 3514 91 6 6 CD cord-010119-t1x9gknd 3514 92 2.0x10 2.0x10 CD cord-010119-t1x9gknd 3514 93 10 10 CD cord-010119-t1x9gknd 3514 94 1.0x10 1.0x10 CD cord-010119-t1x9gknd 3514 95 11 11 CD cord-010119-t1x9gknd 3514 96 6 6 CD cord-010119-t1x9gknd 3514 97 6.1x10 6.1x10 CD cord-010119-t1x9gknd 3514 98 10 10 CD cord-010119-t1x9gknd 3514 99 520 520 CD cord-010119-t1x9gknd 3514 100 6 6 CD cord-010119-t1x9gknd 3514 101 320 320 CD cord-010119-t1x9gknd 3514 102 700 700 CD cord-010119-t1x9gknd 3514 103 6 6 CD cord-010119-t1x9gknd 3514 104 310 310 CD cord-010119-t1x9gknd 3514 105 2200 2200 CD cord-010119-t1x9gknd 3514 106 6 6 CD cord-010119-t1x9gknd 3514 107 1900 1900 CD cord-010119-t1x9gknd 3514 108 9800 9800 CD cord-010119-t1x9gknd 3514 109 6 6 CD cord-010119-t1x9gknd 3514 110 4100 4100 CD cord-010119-t1x9gknd 3514 111 14 14 CD cord-010119-t1x9gknd 3514 112 6 6 CD cord-010119-t1x9gknd 3514 113 17 17 CD cord-010119-t1x9gknd 3514 114 7 7 CD cord-010119-t1x9gknd 3514 115 6 6 CD cord-010119-t1x9gknd 3514 116 5 5 CD cord-010119-t1x9gknd 3515 1 466 466 CD cord-010119-t1x9gknd 3515 2 15 15 CD cord-010119-t1x9gknd 3515 3 120 120 CD cord-010119-t1x9gknd 3516 1 6 6 CD cord-010119-t1x9gknd 3516 2 24 24 CD cord-010119-t1x9gknd 3516 3 WBD WBD NNP cord-010119-t1x9gknd 3516 4 6.4x10 6.4x10 CD cord-010119-t1x9gknd 3516 5 9 9 CD cord-010119-t1x9gknd 3516 6 6 6 CD cord-010119-t1x9gknd 3516 7 3.1x10 3.1x10 CD cord-010119-t1x9gknd 3516 8 9 9 CD cord-010119-t1x9gknd 3516 9 4.6x10 4.6x10 CD cord-010119-t1x9gknd 3516 10 10 10 CD cord-010119-t1x9gknd 3516 11 6 6 CD cord-010119-t1x9gknd 3516 12 1.5x10 1.5x10 CD cord-010119-t1x9gknd 3516 13 10 10 CD cord-010119-t1x9gknd 3516 14 350 350 CD cord-010119-t1x9gknd 3516 15 6 6 CD cord-010119-t1x9gknd 3516 16 140 140 CD cord-010119-t1x9gknd 3516 17 760 760 CD cord-010119-t1x9gknd 3516 18 6 6 CD cord-010119-t1x9gknd 3516 19 360 360 CD cord-010119-t1x9gknd 3516 20 1000 1000 CD cord-010119-t1x9gknd 3516 21 6 6 CD cord-010119-t1x9gknd 3516 22 180 180 CD cord-010119-t1x9gknd 3516 23 4400 4400 CD cord-010119-t1x9gknd 3516 24 6 6 CD cord-010119-t1x9gknd 3516 25 2400 2400 CD cord-010119-t1x9gknd 3516 26 3 3 CD cord-010119-t1x9gknd 3516 27 6 6 CD cord-010119-t1x9gknd 3516 28 2 2 CD cord-010119-t1x9gknd 3516 29 426 426 CD cord-010119-t1x9gknd 3517 1 23 23 CD cord-010119-t1x9gknd 3517 2 57 57 CD cord-010119-t1x9gknd 3517 3 6 6 CD cord-010119-t1x9gknd 3517 4 24 24 CD cord-010119-t1x9gknd 3517 5 120 120 CD cord-010119-t1x9gknd 3518 1 6 6 CD cord-010119-t1x9gknd 3518 2 56 56 CD cord-010119-t1x9gknd 3518 3 Platelet platelet NN cord-010119-t1x9gknd 3518 4 collections collection NNS cord-010119-t1x9gknd 3518 5 must must MD cord-010119-t1x9gknd 3518 6 meet meet VB cord-010119-t1x9gknd 3518 7 specific specific JJ cord-010119-t1x9gknd 3518 8 volume volume NN cord-010119-t1x9gknd 3518 9 , , , cord-010119-t1x9gknd 3518 10 concentration concentration NN cord-010119-t1x9gknd 3518 11 , , , cord-010119-t1x9gknd 3518 12 and and CC cord-010119-t1x9gknd 3518 13 dose dose NN cord-010119-t1x9gknd 3518 14 ranges range NNS cord-010119-t1x9gknd 3518 15 to to TO cord-010119-t1x9gknd 3518 16 qualify qualify VB cord-010119-t1x9gknd 3518 17 for for IN cord-010119-t1x9gknd 3518 18 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 3518 19 PR PR NNP cord-010119-t1x9gknd 3518 20 . . . cord-010119-t1x9gknd 3519 1 Changes change NNS cord-010119-t1x9gknd 3519 2 made make VBN cord-010119-t1x9gknd 3519 3 to to IN cord-010119-t1x9gknd 3519 4 apheresis apheresis NN cord-010119-t1x9gknd 3519 5 devices device NNS cord-010119-t1x9gknd 3519 6 included include VBD cord-010119-t1x9gknd 3519 7 adding add VBG cord-010119-t1x9gknd 3519 8 the the DT cord-010119-t1x9gknd 3519 9 following following JJ cord-010119-t1x9gknd 3519 10 4 4 CD cord-010119-t1x9gknd 3519 11 collection collection NN cord-010119-t1x9gknd 3519 12 targets target NNS cord-010119-t1x9gknd 3519 13 : : : cord-010119-t1x9gknd 3519 14 4.4x10 4.4x10 CD cord-010119-t1x9gknd 3519 15 11 11 CD cord-010119-t1x9gknd 3519 16 in in IN cord-010119-t1x9gknd 3519 17 350mL 350ml NN cord-010119-t1x9gknd 3519 18 , , , cord-010119-t1x9gknd 3519 19 6.6x10 6.6x10 CD cord-010119-t1x9gknd 3519 20 11 11 CD cord-010119-t1x9gknd 3519 21 in in IN cord-010119-t1x9gknd 3519 22 400mL 400ml CD cord-010119-t1x9gknd 3519 23 , , , cord-010119-t1x9gknd 3519 24 6.8x10 6.8x10 CD cord-010119-t1x9gknd 3519 25 11 11 CD cord-010119-t1x9gknd 3519 26 in in IN cord-010119-t1x9gknd 3519 27 400mL 400ml CD cord-010119-t1x9gknd 3519 28 , , , cord-010119-t1x9gknd 3519 29 and and CC cord-010119-t1x9gknd 3519 30 7.0x10 7.0x10 CD cord-010119-t1x9gknd 3519 31 11 11 CD cord-010119-t1x9gknd 3519 32 in in IN cord-010119-t1x9gknd 3519 33 400mL. 400ml. CD cord-010119-t1x9gknd 3519 34 Study Study NNP cord-010119-t1x9gknd 3519 35 Design Design NNP cord-010119-t1x9gknd 3519 36 / / SYM cord-010119-t1x9gknd 3519 37 Methods method NNS cord-010119-t1x9gknd 3519 38 : : : cord-010119-t1x9gknd 3519 39 Four four CD cord-010119-t1x9gknd 3519 40 months month NNS cord-010119-t1x9gknd 3519 41 of of IN cord-010119-t1x9gknd 3519 42 collections collection NNS cord-010119-t1x9gknd 3519 43 were be VBD cord-010119-t1x9gknd 3519 44 retrospectively retrospectively RB cord-010119-t1x9gknd 3519 45 analyzed analyze VBN cord-010119-t1x9gknd 3519 46 . . . cord-010119-t1x9gknd 3520 1 Platelet platelet NN cord-010119-t1x9gknd 3520 2 collections collection NNS cord-010119-t1x9gknd 3520 3 were be VBD cord-010119-t1x9gknd 3520 4 evaluated evaluate VBN cord-010119-t1x9gknd 3520 5 to to TO cord-010119-t1x9gknd 3520 6 determine determine VB cord-010119-t1x9gknd 3520 7 eligibility eligibility NN cord-010119-t1x9gknd 3520 8 for for IN cord-010119-t1x9gknd 3520 9 PR PR NNP cord-010119-t1x9gknd 3520 10 treatment treatment NN cord-010119-t1x9gknd 3520 11 , , , cord-010119-t1x9gknd 3520 12 and and CC cord-010119-t1x9gknd 3520 13 all all DT cord-010119-t1x9gknd 3520 14 products product NNS cord-010119-t1x9gknd 3520 15 meeting meeting NN cord-010119-t1x9gknd 3520 16 PR PR NNP cord-010119-t1x9gknd 3520 17 processing processing NN cord-010119-t1x9gknd 3520 18 specifications specification NNS cord-010119-t1x9gknd 3520 19 ( ( -LRB- cord-010119-t1x9gknd 3520 20 unless unless IN cord-010119-t1x9gknd 3520 21 intended intend VBN cord-010119-t1x9gknd 3520 22 for for IN cord-010119-t1x9gknd 3520 23 an an DT cord-010119-t1x9gknd 3520 24 HLA HLA NNP cord-010119-t1x9gknd 3520 25 matched match VBN cord-010119-t1x9gknd 3520 26 recipient recipient NN cord-010119-t1x9gknd 3520 27 at at IN cord-010119-t1x9gknd 3520 28 a a DT cord-010119-t1x9gknd 3520 29 hospital hospital NN cord-010119-t1x9gknd 3520 30 not not RB cord-010119-t1x9gknd 3520 31 able able JJ cord-010119-t1x9gknd 3520 32 to to TO cord-010119-t1x9gknd 3520 33 accept accept VB cord-010119-t1x9gknd 3520 34 PR PR NNP cord-010119-t1x9gknd 3520 35 products product NNS cord-010119-t1x9gknd 3520 36 ) ) -RRB- cord-010119-t1x9gknd 3520 37 underwent undergo VBD cord-010119-t1x9gknd 3520 38 PR pr NN cord-010119-t1x9gknd 3520 39 treatment treatment NN cord-010119-t1x9gknd 3520 40 regardless regardless RB cord-010119-t1x9gknd 3520 41 of of IN cord-010119-t1x9gknd 3520 42 potential potential JJ cord-010119-t1x9gknd 3520 43 impact impact NN cord-010119-t1x9gknd 3520 44 to to TO cord-010119-t1x9gknd 3520 45 split split JJ cord-010119-t1x9gknd 3520 46 rate rate NN cord-010119-t1x9gknd 3520 47 . . . cord-010119-t1x9gknd 3521 1 A a DT cord-010119-t1x9gknd 3521 2 minimum minimum JJ cord-010119-t1x9gknd 3521 3 post post JJ cord-010119-t1x9gknd 3521 4 - - JJ cord-010119-t1x9gknd 3521 5 treatment treatment JJ cord-010119-t1x9gknd 3521 6 dose dose NN cord-010119-t1x9gknd 3521 7 of of IN cord-010119-t1x9gknd 3521 8 3.0x10 3.0x10 CD cord-010119-t1x9gknd 3521 9 11 11 CD cord-010119-t1x9gknd 3521 10 or or CC cord-010119-t1x9gknd 3521 11 6.0x10 6.0x10 CD cord-010119-t1x9gknd 3521 12 11 11 CD cord-010119-t1x9gknd 3521 13 was be VBD cord-010119-t1x9gknd 3521 14 required require VBN cord-010119-t1x9gknd 3521 15 to to TO cord-010119-t1x9gknd 3521 16 classify classify VB cord-010119-t1x9gknd 3521 17 collections collection NNS cord-010119-t1x9gknd 3521 18 as as IN cord-010119-t1x9gknd 3521 19 singles single NNS cord-010119-t1x9gknd 3521 20 or or CC cord-010119-t1x9gknd 3521 21 doubles double VBZ cord-010119-t1x9gknd 3521 22 respectively respectively RB cord-010119-t1x9gknd 3521 23 . . . cord-010119-t1x9gknd 3522 1 Volume volume NN cord-010119-t1x9gknd 3522 2 / / SYM cord-010119-t1x9gknd 3522 3 dose dose NN cord-010119-t1x9gknd 3522 4 mitigation mitigation NN cord-010119-t1x9gknd 3522 5 ( ( -LRB- cord-010119-t1x9gknd 3522 6 removal removal NN cord-010119-t1x9gknd 3522 7 of of IN cord-010119-t1x9gknd 3522 8 volume volume NN cord-010119-t1x9gknd 3522 9 to to TO cord-010119-t1x9gknd 3522 10 increase increase VB cord-010119-t1x9gknd 3522 11 the the DT cord-010119-t1x9gknd 3522 12 number number NN cord-010119-t1x9gknd 3522 13 of of IN cord-010119-t1x9gknd 3522 14 products product NNS cord-010119-t1x9gknd 3522 15 eligible eligible JJ cord-010119-t1x9gknd 3522 16 for for IN cord-010119-t1x9gknd 3522 17 PR PR NNP cord-010119-t1x9gknd 3522 18 ) ) -RRB- cord-010119-t1x9gknd 3522 19 was be VBD cord-010119-t1x9gknd 3522 20 not not RB cord-010119-t1x9gknd 3522 21 utilized utilize VBN cord-010119-t1x9gknd 3522 22 during during IN cord-010119-t1x9gknd 3522 23 this this DT cord-010119-t1x9gknd 3522 24 study study NN cord-010119-t1x9gknd 3522 25 . . . cord-010119-t1x9gknd 3523 1 Thus thus RB cord-010119-t1x9gknd 3523 2 units unit NNS cord-010119-t1x9gknd 3523 3 were be VBD cord-010119-t1x9gknd 3523 4 treated treat VBN cord-010119-t1x9gknd 3523 5 conventionally conventionally RB cord-010119-t1x9gknd 3523 6 if if IN cord-010119-t1x9gknd 3523 7 volume volume NN cord-010119-t1x9gknd 3523 8 , , , cord-010119-t1x9gknd 3523 9 dose dose NN cord-010119-t1x9gknd 3523 10 , , , cord-010119-t1x9gknd 3523 11 and/or and/or CC cord-010119-t1x9gknd 3523 12 concentration concentration NN cord-010119-t1x9gknd 3523 13 did do VBD cord-010119-t1x9gknd 3523 14 not not RB cord-010119-t1x9gknd 3523 15 meet meet VB cord-010119-t1x9gknd 3523 16 PR PR NNP cord-010119-t1x9gknd 3523 17 specifications specification NNS cord-010119-t1x9gknd 3523 18 without without IN cord-010119-t1x9gknd 3523 19 further further JJ cord-010119-t1x9gknd 3523 20 manipulation manipulation NN cord-010119-t1x9gknd 3523 21 . . . cord-010119-t1x9gknd 3524 1 Results result NNS cord-010119-t1x9gknd 3524 2 / / SYM cord-010119-t1x9gknd 3524 3 Findings finding NNS cord-010119-t1x9gknd 3524 4 : : : cord-010119-t1x9gknd 3524 5 64 64 CD cord-010119-t1x9gknd 3524 6 % % NN cord-010119-t1x9gknd 3524 7 of of IN cord-010119-t1x9gknd 3524 8 all all DT cord-010119-t1x9gknd 3524 9 single single JJ cord-010119-t1x9gknd 3524 10 and and CC cord-010119-t1x9gknd 3524 11 double double JJ cord-010119-t1x9gknd 3524 12 collections collection NNS cord-010119-t1x9gknd 3524 13 were be VBD cord-010119-t1x9gknd 3524 14 eligible eligible JJ cord-010119-t1x9gknd 3524 15 for for IN cord-010119-t1x9gknd 3524 16 and and CC cord-010119-t1x9gknd 3524 17 underwent undergo VBD cord-010119-t1x9gknd 3524 18 PR PR NNP cord-010119-t1x9gknd 3524 19 treatment treatment NN cord-010119-t1x9gknd 3524 20 . . . cord-010119-t1x9gknd 3525 1 Split split JJ cord-010119-t1x9gknd 3525 2 rate rate NN cord-010119-t1x9gknd 3525 3 for for IN cord-010119-t1x9gknd 3525 4 single single JJ cord-010119-t1x9gknd 3525 5 and and CC cord-010119-t1x9gknd 3525 6 double double JJ cord-010119-t1x9gknd 3525 7 collections collection NNS cord-010119-t1x9gknd 3525 8 was be VBD cord-010119-t1x9gknd 3525 9 1.34 1.34 CD cord-010119-t1x9gknd 3525 10 . . . cord-010119-t1x9gknd 3526 1 Conclusion conclusion NN cord-010119-t1x9gknd 3526 2 : : : cord-010119-t1x9gknd 3527 1 It -PRON- PRP cord-010119-t1x9gknd 3527 2 is be VBZ cord-010119-t1x9gknd 3527 3 possible possible JJ cord-010119-t1x9gknd 3527 4 to to TO cord-010119-t1x9gknd 3527 5 treat treat VB cord-010119-t1x9gknd 3527 6 64 64 CD cord-010119-t1x9gknd 3527 7 % % NN cord-010119-t1x9gknd 3527 8 of of IN cord-010119-t1x9gknd 3527 9 single single JJ cord-010119-t1x9gknd 3527 10 and and CC cord-010119-t1x9gknd 3527 11 double double JJ cord-010119-t1x9gknd 3527 12 platelet platelet NN cord-010119-t1x9gknd 3527 13 donations donation NNS cord-010119-t1x9gknd 3527 14 with with IN cord-010119-t1x9gknd 3527 15 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 3527 16 PR PR NNP cord-010119-t1x9gknd 3527 17 at at IN cord-010119-t1x9gknd 3527 18 the the DT cord-010119-t1x9gknd 3527 19 blood blood NN cord-010119-t1x9gknd 3527 20 center center NN cord-010119-t1x9gknd 3527 21 's 's POS cord-010119-t1x9gknd 3527 22 current current JJ cord-010119-t1x9gknd 3527 23 state state NN cord-010119-t1x9gknd 3527 24 with with IN cord-010119-t1x9gknd 3527 25 only only RB cord-010119-t1x9gknd 3527 26 a a DT cord-010119-t1x9gknd 3527 27 slight slight JJ cord-010119-t1x9gknd 3527 28 impact impact NN cord-010119-t1x9gknd 3527 29 to to IN cord-010119-t1x9gknd 3527 30 split split JJ cord-010119-t1x9gknd 3527 31 rate rate NN cord-010119-t1x9gknd 3527 32 if if IN cord-010119-t1x9gknd 3527 33 centers center NNS cord-010119-t1x9gknd 3527 34 are be VBP cord-010119-t1x9gknd 3527 35 willing willing JJ cord-010119-t1x9gknd 3527 36 to to TO cord-010119-t1x9gknd 3527 37 make make VB cord-010119-t1x9gknd 3527 38 alterations alteration NNS cord-010119-t1x9gknd 3527 39 to to IN cord-010119-t1x9gknd 3527 40 their -PRON- PRP$ cord-010119-t1x9gknd 3527 41 targeting target VBG cord-010119-t1x9gknd 3527 42 practices practice NNS cord-010119-t1x9gknd 3527 43 . . . cord-010119-t1x9gknd 3528 1 Platelet platelet NN cord-010119-t1x9gknd 3528 2 collections collection NNS cord-010119-t1x9gknd 3528 3 that that WDT cord-010119-t1x9gknd 3528 4 fall fall VBP cord-010119-t1x9gknd 3528 5 outside outside RB cord-010119-t1x9gknd 3528 6 of of IN cord-010119-t1x9gknd 3528 7 the the DT cord-010119-t1x9gknd 3528 8 specifications specification NNS cord-010119-t1x9gknd 3528 9 for for IN cord-010119-t1x9gknd 3528 10 PR PR NNP cord-010119-t1x9gknd 3528 11 are be VBP cord-010119-t1x9gknd 3528 12 processed process VBN cord-010119-t1x9gknd 3528 13 and and CC cord-010119-t1x9gknd 3528 14 distributed distribute VBN cord-010119-t1x9gknd 3528 15 as as IN cord-010119-t1x9gknd 3528 16 conventional conventional JJ cord-010119-t1x9gknd 3528 17 products product NNS cord-010119-t1x9gknd 3528 18 . . . cord-010119-t1x9gknd 3529 1 Strategies strategy NNS cord-010119-t1x9gknd 3529 2 to to TO cord-010119-t1x9gknd 3529 3 increase increase VB cord-010119-t1x9gknd 3529 4 eligibility eligibility NN cord-010119-t1x9gknd 3529 5 toward toward IN cord-010119-t1x9gknd 3529 6 100 100 CD cord-010119-t1x9gknd 3529 7 % % NN cord-010119-t1x9gknd 3529 8 while while IN cord-010119-t1x9gknd 3529 9 minimizing minimize VBG cord-010119-t1x9gknd 3529 10 impact impact NN cord-010119-t1x9gknd 3529 11 to to IN cord-010119-t1x9gknd 3529 12 split split JJ cord-010119-t1x9gknd 3529 13 rate rate NN cord-010119-t1x9gknd 3529 14 are be VBP cord-010119-t1x9gknd 3529 15 being be VBG cord-010119-t1x9gknd 3529 16 investigated investigate VBN cord-010119-t1x9gknd 3529 17 , , , cord-010119-t1x9gknd 3529 18 including include VBG cord-010119-t1x9gknd 3529 19 incorporating incorporate VBG cord-010119-t1x9gknd 3529 20 new new JJ cord-010119-t1x9gknd 3529 21 collection collection NN cord-010119-t1x9gknd 3529 22 settings setting NNS cord-010119-t1x9gknd 3529 23 , , , cord-010119-t1x9gknd 3529 24 splitting splitting NN cord-010119-t1x9gknd 3529 25 triples triple NNS cord-010119-t1x9gknd 3529 26 , , , cord-010119-t1x9gknd 3529 27 and and CC cord-010119-t1x9gknd 3529 28 volume volume NN cord-010119-t1x9gknd 3529 29 / / SYM cord-010119-t1x9gknd 3529 30 dose dose NN cord-010119-t1x9gknd 3529 31 mitigation mitigation NN cord-010119-t1x9gknd 3529 32 . . . cord-010119-t1x9gknd 3530 1 Further further JJ cord-010119-t1x9gknd 3530 2 evaluation evaluation NN cord-010119-t1x9gknd 3530 3 is be VBZ cord-010119-t1x9gknd 3530 4 needed need VBN cord-010119-t1x9gknd 3530 5 to to TO cord-010119-t1x9gknd 3530 6 determine determine VB cord-010119-t1x9gknd 3530 7 the the DT cord-010119-t1x9gknd 3530 8 additional additional JJ cord-010119-t1x9gknd 3530 9 quantity quantity NN cord-010119-t1x9gknd 3530 10 of of IN cord-010119-t1x9gknd 3530 11 PR PR NNP cord-010119-t1x9gknd 3530 12 eligible eligible JJ cord-010119-t1x9gknd 3530 13 products product NNS cord-010119-t1x9gknd 3530 14 resulting result VBG cord-010119-t1x9gknd 3530 15 from from IN cord-010119-t1x9gknd 3530 16 such such JJ cord-010119-t1x9gknd 3530 17 changes change NNS cord-010119-t1x9gknd 3530 18 . . . cord-010119-t1x9gknd 3531 1 Monique Monique NNP cord-010119-t1x9gknd 3531 2 P P NNP cord-010119-t1x9gknd 3531 3 Gelderman Gelderman NNP cord-010119-t1x9gknd 3531 4 * * NFP cord-010119-t1x9gknd 3531 5 1 1 CD cord-010119-t1x9gknd 3531 6 , , , cord-010119-t1x9gknd 3531 7 Andrey Andrey NNP cord-010119-t1x9gknd 3531 8 Skripchenko Skripchenko NNP cord-010119-t1x9gknd 3531 9 1 1 CD cord-010119-t1x9gknd 3531 10 , , , cord-010119-t1x9gknd 3531 11 Fei Fei NNP cord-010119-t1x9gknd 3531 12 Xu Xu NNP cord-010119-t1x9gknd 3531 13 1 1 CD cord-010119-t1x9gknd 3531 14 , , , cord-010119-t1x9gknd 3531 15 Ying Ying NNP cord-010119-t1x9gknd 3531 16 Li Li NNP cord-010119-t1x9gknd 3531 17 1 1 CD cord-010119-t1x9gknd 3531 18 , , , cord-010119-t1x9gknd 3531 19 Stephen Stephen NNP cord-010119-t1x9gknd 3531 20 J J NNP cord-010119-t1x9gknd 3531 21 Wagner Wagner NNP cord-010119-t1x9gknd 3531 22 2 2 CD cord-010119-t1x9gknd 3531 23 , , , cord-010119-t1x9gknd 3531 24 Pamela Pamela NNP cord-010119-t1x9gknd 3531 25 H H NNP cord-010119-t1x9gknd 3531 26 Whitley Whitley NNP cord-010119-t1x9gknd 3531 27 3 3 CD cord-010119-t1x9gknd 3531 28 and and CC cord-010119-t1x9gknd 3531 29 Jaroslav Jaroslav NNP cord-010119-t1x9gknd 3531 30 G G NNP cord-010119-t1x9gknd 3531 31 Vostal Vostal NNP cord-010119-t1x9gknd 3532 1 1 1 LS cord-010119-t1x9gknd 3532 2 . . . cord-010119-t1x9gknd 3533 1 1 1 CD cord-010119-t1x9gknd 3533 2 FDA FDA NNP cord-010119-t1x9gknd 3533 3 / / SYM cord-010119-t1x9gknd 3533 4 CBER/ CBER/ NNP cord-010119-t1x9gknd 3533 5 OBRR OBRR NNP cord-010119-t1x9gknd 3533 6 / / SYM cord-010119-t1x9gknd 3533 7 DBCD DBCD NNP cord-010119-t1x9gknd 3533 8 / / SYM cord-010119-t1x9gknd 3533 9 LCH LCH NNP cord-010119-t1x9gknd 3533 10 , , , cord-010119-t1x9gknd 3533 11 2 2 CD cord-010119-t1x9gknd 3533 12 American American NNP cord-010119-t1x9gknd 3533 13 Red Red NNP cord-010119-t1x9gknd 3533 14 Cross Cross NNP cord-010119-t1x9gknd 3533 15 Holland Holland NNP cord-010119-t1x9gknd 3533 16 Laboratory Laboratory NNP cord-010119-t1x9gknd 3533 17 , , , cord-010119-t1x9gknd 3533 18 3 3 CD cord-010119-t1x9gknd 3533 19 American American NNP cord-010119-t1x9gknd 3533 20 Red Red NNP cord-010119-t1x9gknd 3533 21 Cross Cross NNP cord-010119-t1x9gknd 3533 22 Mid Mid NNP cord-010119-t1x9gknd 3533 23 - - HYPH cord-010119-t1x9gknd 3533 24 Atlantic Atlantic NNP cord-010119-t1x9gknd 3533 25 Research Research NNP cord-010119-t1x9gknd 3533 26 Facility Facility NNP cord-010119-t1x9gknd 3533 27 Background Background NNP cord-010119-t1x9gknd 3533 28 / / SYM cord-010119-t1x9gknd 3533 29 Case Case NNP cord-010119-t1x9gknd 3533 30 Studies Studies NNPS cord-010119-t1x9gknd 3533 31 : : : cord-010119-t1x9gknd 3533 32 Platelets platelet NNS cord-010119-t1x9gknd 3533 33 ( ( -LRB- cord-010119-t1x9gknd 3533 34 PLTs plt NNS cord-010119-t1x9gknd 3533 35 ) ) -RRB- cord-010119-t1x9gknd 3533 36 stored store VBN cord-010119-t1x9gknd 3533 37 at at IN cord-010119-t1x9gknd 3533 38 room room NN cord-010119-t1x9gknd 3533 39 temperature temperature NN cord-010119-t1x9gknd 3533 40 ( ( -LRB- cord-010119-t1x9gknd 3533 41 RT RT NNP cord-010119-t1x9gknd 3533 42 ) ) -RRB- cord-010119-t1x9gknd 3533 43 can can MD cord-010119-t1x9gknd 3533 44 support support VB cord-010119-t1x9gknd 3533 45 bacterial bacterial JJ cord-010119-t1x9gknd 3533 46 proliferation proliferation NN cord-010119-t1x9gknd 3533 47 in in IN cord-010119-t1x9gknd 3533 48 contaminated contaminated JJ cord-010119-t1x9gknd 3533 49 units unit NNS cord-010119-t1x9gknd 3533 50 and and CC cord-010119-t1x9gknd 3533 51 therefore therefore RB cord-010119-t1x9gknd 3533 52 septic septic JJ cord-010119-t1x9gknd 3533 53 transfusion transfusion NN cord-010119-t1x9gknd 3533 54 reactions reaction NNS cord-010119-t1x9gknd 3533 55 may may MD cord-010119-t1x9gknd 3533 56 occur occur VB cord-010119-t1x9gknd 3533 57 . . . cord-010119-t1x9gknd 3534 1 Storing store VBG cord-010119-t1x9gknd 3534 2 PLTs plt NNS cord-010119-t1x9gknd 3534 3 at at IN cord-010119-t1x9gknd 3534 4 cold cold JJ cord-010119-t1x9gknd 3534 5 temperature temperature NN cord-010119-t1x9gknd 3534 6 ( ( -LRB- cord-010119-t1x9gknd 3534 7 4 4 CD cord-010119-t1x9gknd 3534 8 - - SYM cord-010119-t1x9gknd 3534 9 6 6 CD cord-010119-t1x9gknd 3534 10 o o NN cord-010119-t1x9gknd 3534 11 C c NN cord-010119-t1x9gknd 3534 12 [ [ -LRB- cord-010119-t1x9gknd 3534 13 CT CT NNP cord-010119-t1x9gknd 3534 14 ] ] -RRB- cord-010119-t1x9gknd 3534 15 ) ) -RRB- cord-010119-t1x9gknd 3534 16 limits limit VBZ cord-010119-t1x9gknd 3534 17 bacterial bacterial JJ cord-010119-t1x9gknd 3534 18 growth growth NN cord-010119-t1x9gknd 3534 19 but but CC cord-010119-t1x9gknd 3534 20 results result NNS cord-010119-t1x9gknd 3534 21 in in IN cord-010119-t1x9gknd 3534 22 rapid rapid JJ cord-010119-t1x9gknd 3534 23 clearance clearance NN cord-010119-t1x9gknd 3534 24 upon upon IN cord-010119-t1x9gknd 3534 25 transfusion transfusion NN cord-010119-t1x9gknd 3534 26 . . . cord-010119-t1x9gknd 3535 1 The the DT cord-010119-t1x9gknd 3535 2 development development NN cord-010119-t1x9gknd 3535 3 of of IN cord-010119-t1x9gknd 3535 4 alternate alternate JJ cord-010119-t1x9gknd 3535 5 storage storage NN cord-010119-t1x9gknd 3535 6 conditions condition NNS cord-010119-t1x9gknd 3535 7 usually usually RB cord-010119-t1x9gknd 3535 8 involves involve VBZ cord-010119-t1x9gknd 3535 9 costly costly JJ cord-010119-t1x9gknd 3535 10 radiolabeling radiolabele VBG cord-010119-t1x9gknd 3535 11 human human JJ cord-010119-t1x9gknd 3535 12 studies study NNS cord-010119-t1x9gknd 3535 13 but but CC cord-010119-t1x9gknd 3535 14 success success NN cord-010119-t1x9gknd 3535 15 in in IN cord-010119-t1x9gknd 3535 16 these these DT cord-010119-t1x9gknd 3535 17 studies study NNS cord-010119-t1x9gknd 3535 18 is be VBZ cord-010119-t1x9gknd 3535 19 difficult difficult JJ cord-010119-t1x9gknd 3535 20 to to TO cord-010119-t1x9gknd 3535 21 predict predict VB cord-010119-t1x9gknd 3535 22 based base VBN cord-010119-t1x9gknd 3535 23 on on IN cord-010119-t1x9gknd 3535 24 in in IN cord-010119-t1x9gknd 3535 25 vitro vitro FW cord-010119-t1x9gknd 3535 26 studies study NNS cord-010119-t1x9gknd 3535 27 . . . cord-010119-t1x9gknd 3536 1 Thus thus RB cord-010119-t1x9gknd 3536 2 , , , cord-010119-t1x9gknd 3536 3 an an DT cord-010119-t1x9gknd 3536 4 animal animal NN cord-010119-t1x9gknd 3536 5 model model NN cord-010119-t1x9gknd 3536 6 of of IN cord-010119-t1x9gknd 3536 7 PLT PLT NNP cord-010119-t1x9gknd 3536 8 circulation circulation NN cord-010119-t1x9gknd 3536 9 that that WDT cord-010119-t1x9gknd 3536 10 could could MD cord-010119-t1x9gknd 3536 11 predict predict VB cord-010119-t1x9gknd 3536 12 performance performance NN cord-010119-t1x9gknd 3536 13 of of IN cord-010119-t1x9gknd 3536 14 human human JJ cord-010119-t1x9gknd 3536 15 PLTs plt NNS cord-010119-t1x9gknd 3536 16 in in IN cord-010119-t1x9gknd 3536 17 human human JJ cord-010119-t1x9gknd 3536 18 volunteers volunteer NNS cord-010119-t1x9gknd 3536 19 would would MD cord-010119-t1x9gknd 3536 20 positively positively RB cord-010119-t1x9gknd 3536 21 impact impact VB cord-010119-t1x9gknd 3536 22 the the DT cord-010119-t1x9gknd 3536 23 development development NN cord-010119-t1x9gknd 3536 24 of of IN cord-010119-t1x9gknd 3536 25 alternate alternate JJ cord-010119-t1x9gknd 3536 26 storage storage NN cord-010119-t1x9gknd 3536 27 conditions condition NNS cord-010119-t1x9gknd 3536 28 . . . cord-010119-t1x9gknd 3537 1 Study Study NNP cord-010119-t1x9gknd 3537 2 Design Design NNP cord-010119-t1x9gknd 3537 3 / / SYM cord-010119-t1x9gknd 3537 4 Method method NN cord-010119-t1x9gknd 3537 5 : : : cord-010119-t1x9gknd 3537 6 We -PRON- PRP cord-010119-t1x9gknd 3537 7 designed design VBD cord-010119-t1x9gknd 3537 8 an an DT cord-010119-t1x9gknd 3537 9 immunodeficient immunodeficient JJ cord-010119-t1x9gknd 3537 10 ( ( -LRB- cord-010119-t1x9gknd 3537 11 SCID SCID NNP cord-010119-t1x9gknd 3537 12 ) ) -RRB- cord-010119-t1x9gknd 3537 13 mouse mouse NN cord-010119-t1x9gknd 3537 14 model model NN cord-010119-t1x9gknd 3537 15 to to TO cord-010119-t1x9gknd 3537 16 evaluate evaluate VB cord-010119-t1x9gknd 3537 17 recovery recovery NN cord-010119-t1x9gknd 3537 18 of of IN cord-010119-t1x9gknd 3537 19 human human JJ cord-010119-t1x9gknd 3537 20 PLTs plt NNS cord-010119-t1x9gknd 3537 21 and and CC cord-010119-t1x9gknd 3537 22 compared compare VBN cord-010119-t1x9gknd 3537 23 this this DT cord-010119-t1x9gknd 3537 24 side side NN cord-010119-t1x9gknd 3537 25 by by IN cord-010119-t1x9gknd 3537 26 side side NN cord-010119-t1x9gknd 3537 27 to to IN cord-010119-t1x9gknd 3537 28 a a DT cord-010119-t1x9gknd 3537 29 radiolabeling radiolabele VBG cord-010119-t1x9gknd 3537 30 study study NN cord-010119-t1x9gknd 3537 31 in in IN cord-010119-t1x9gknd 3537 32 human human JJ cord-010119-t1x9gknd 3537 33 volunteers volunteer NNS cord-010119-t1x9gknd 3537 34 that that WDT cord-010119-t1x9gknd 3537 35 was be VBD cord-010119-t1x9gknd 3537 36 conducted conduct VBN cord-010119-t1x9gknd 3537 37 for for IN cord-010119-t1x9gknd 3537 38 evaluating evaluate VBG cord-010119-t1x9gknd 3537 39 a a DT cord-010119-t1x9gknd 3537 40 new new JJ cord-010119-t1x9gknd 3537 41 PLT PLT NNP cord-010119-t1x9gknd 3537 42 storage storage NN cord-010119-t1x9gknd 3537 43 condition condition NN cord-010119-t1x9gknd 3537 44 : : : cord-010119-t1x9gknd 3537 45 thermocycling thermocycling NNP cord-010119-t1x9gknd 3537 46 PLTs PLTs NNP cord-010119-t1x9gknd 3537 47 ( ( -LRB- cord-010119-t1x9gknd 3537 48 11 11 CD cord-010119-t1x9gknd 3537 49 hrs hrs NN cord-010119-t1x9gknd 3537 50 CT CT NNP cord-010119-t1x9gknd 3537 51 : : : cord-010119-t1x9gknd 3537 52 1 1 CD cord-010119-t1x9gknd 3537 53 hr hr NN cord-010119-t1x9gknd 3537 54 37 37 CD cord-010119-t1x9gknd 3537 55 o o NN cord-010119-t1x9gknd 3537 56 C c NN cord-010119-t1x9gknd 3537 57 [ [ -LRB- cord-010119-t1x9gknd 3537 58 TC TC NNP cord-010119-t1x9gknd 3537 59 ] ] -RRB- cord-010119-t1x9gknd 3537 60 ) ) -RRB- cord-010119-t1x9gknd 3537 61 . . . cord-010119-t1x9gknd 3538 1 Autologous autologous JJ cord-010119-t1x9gknd 3538 2 apheresis apheresis NN cord-010119-t1x9gknd 3538 3 PLTs plt NNS cord-010119-t1x9gknd 3538 4 stored store VBN cord-010119-t1x9gknd 3538 5 for for IN cord-010119-t1x9gknd 3538 6 7-days 7-days CD cord-010119-t1x9gknd 3538 7 at at IN cord-010119-t1x9gknd 3538 8 RT RT NNP cord-010119-t1x9gknd 3538 9 , , , cord-010119-t1x9gknd 3538 10 TC TC NNP cord-010119-t1x9gknd 3538 11 and and CC cord-010119-t1x9gknd 3538 12 CT CT NNP cord-010119-t1x9gknd 3538 13 were be VBD cord-010119-t1x9gknd 3538 14 radiolabeled radiolabele VBN cord-010119-t1x9gknd 3538 15 and and CC cord-010119-t1x9gknd 3538 16 infused infuse VBN cord-010119-t1x9gknd 3538 17 into into IN cord-010119-t1x9gknd 3538 18 healthy healthy JJ cord-010119-t1x9gknd 3538 19 human human JJ cord-010119-t1x9gknd 3538 20 volunteers volunteer NNS cord-010119-t1x9gknd 3538 21 ( ( -LRB- cord-010119-t1x9gknd 3538 22 n59 n59 NN cord-010119-t1x9gknd 3538 23 ) ) -RRB- cord-010119-t1x9gknd 3538 24 and and CC cord-010119-t1x9gknd 3538 25 the the DT cord-010119-t1x9gknd 3538 26 same same JJ cord-010119-t1x9gknd 3538 27 non non AFX cord-010119-t1x9gknd 3538 28 - - JJ cord-010119-t1x9gknd 3538 29 labeled labeled JJ cord-010119-t1x9gknd 3538 30 PLTs plt NNS cord-010119-t1x9gknd 3538 31 were be VBD cord-010119-t1x9gknd 3538 32 also also RB cord-010119-t1x9gknd 3538 33 infused infuse VBN cord-010119-t1x9gknd 3538 34 into into IN cord-010119-t1x9gknd 3538 35 mice mouse NNS cord-010119-t1x9gknd 3538 36 ( ( -LRB- cord-010119-t1x9gknd 3538 37 n590 n590 NN cord-010119-t1x9gknd 3538 38 ) ) -RRB- cord-010119-t1x9gknd 3538 39 . . . cord-010119-t1x9gknd 3539 1 Blood blood NN cord-010119-t1x9gknd 3539 2 samples sample NNS cord-010119-t1x9gknd 3539 3 from from IN cord-010119-t1x9gknd 3539 4 humans human NNS cord-010119-t1x9gknd 3539 5 and and CC cord-010119-t1x9gknd 3539 6 mice mouse NNS cord-010119-t1x9gknd 3539 7 were be VBD cord-010119-t1x9gknd 3539 8 collected collect VBN cord-010119-t1x9gknd 3539 9 over over IN cord-010119-t1x9gknd 3539 10 time time NN cord-010119-t1x9gknd 3539 11 to to TO cord-010119-t1x9gknd 3539 12 generate generate VB cord-010119-t1x9gknd 3539 13 survival survival NN cord-010119-t1x9gknd 3539 14 and and CC cord-010119-t1x9gknd 3539 15 clearance clearance NN cord-010119-t1x9gknd 3539 16 curves curve NNS cord-010119-t1x9gknd 3539 17 of of IN cord-010119-t1x9gknd 3539 18 the the DT cord-010119-t1x9gknd 3539 19 PLTs plt NNS cord-010119-t1x9gknd 3539 20 in in IN cord-010119-t1x9gknd 3539 21 circulation circulation NN cord-010119-t1x9gknd 3539 22 . . . cord-010119-t1x9gknd 3540 1 Flow flow NN cord-010119-t1x9gknd 3540 2 cytometry cytometry NN cord-010119-t1x9gknd 3540 3 was be VBD cord-010119-t1x9gknd 3540 4 used use VBN cord-010119-t1x9gknd 3540 5 to to TO cord-010119-t1x9gknd 3540 6 detect detect VB cord-010119-t1x9gknd 3540 7 and and CC cord-010119-t1x9gknd 3540 8 analyze analyze VB cord-010119-t1x9gknd 3540 9 the the DT cord-010119-t1x9gknd 3540 10 human human JJ cord-010119-t1x9gknd 3540 11 PLTs plt NNS cord-010119-t1x9gknd 3540 12 in in IN cord-010119-t1x9gknd 3540 13 the the DT cord-010119-t1x9gknd 3540 14 mouse mouse NN cord-010119-t1x9gknd 3540 15 samples sample NNS cord-010119-t1x9gknd 3540 16 to to TO cord-010119-t1x9gknd 3540 17 generate generate VB cord-010119-t1x9gknd 3540 18 such such JJ cord-010119-t1x9gknd 3540 19 curves curve NNS cord-010119-t1x9gknd 3540 20 ; ; : cord-010119-t1x9gknd 3540 21 counts count VBZ cord-010119-t1x9gknd 3540 22 < < XX cord-010119-t1x9gknd 3540 23 5 5 CD cord-010119-t1x9gknd 3540 24 % % NN cord-010119-t1x9gknd 3540 25 were be VBD cord-010119-t1x9gknd 3540 26 considered consider VBN cord-010119-t1x9gknd 3540 27 background background NN cord-010119-t1x9gknd 3540 28 . . . cord-010119-t1x9gknd 3541 1 Results/ Results/ . cord-010119-t1x9gknd 3542 1 Finding finding NN cord-010119-t1x9gknd 3542 2 : : : cord-010119-t1x9gknd 3543 1 The the DT cord-010119-t1x9gknd 3543 2 mean mean JJ cord-010119-t1x9gknd 3543 3 recoveries recovery NNS cord-010119-t1x9gknd 3543 4 of of IN cord-010119-t1x9gknd 3543 5 infused infuse VBN cord-010119-t1x9gknd 3543 6 PLTs plt NNS cord-010119-t1x9gknd 3543 7 were be VBD cord-010119-t1x9gknd 3543 8 51.2 51.2 CD cord-010119-t1x9gknd 3543 9 6 6 CD cord-010119-t1x9gknd 3543 10 16.7 16.7 CD cord-010119-t1x9gknd 3543 11 % % NN cord-010119-t1x9gknd 3543 12 for for IN cord-010119-t1x9gknd 3543 13 RT RT NNP cord-010119-t1x9gknd 3543 14 , , , cord-010119-t1x9gknd 3543 15 37.7 37.7 CD cord-010119-t1x9gknd 3543 16 6 6 CD cord-010119-t1x9gknd 3543 17 12.3 12.3 CD cord-010119-t1x9gknd 3543 18 % % NN cord-010119-t1x9gknd 3543 19 for for IN cord-010119-t1x9gknd 3543 20 TC TC NNP cord-010119-t1x9gknd 3543 21 and and CC cord-010119-t1x9gknd 3543 22 23.1 23.1 CD cord-010119-t1x9gknd 3543 23 6 6 CD cord-010119-t1x9gknd 3543 24 8.8 8.8 CD cord-010119-t1x9gknd 3543 25 % % NN cord-010119-t1x9gknd 3543 26 for for IN cord-010119-t1x9gknd 3543 27 CT CT NNP cord-010119-t1x9gknd 3543 28 in in IN cord-010119-t1x9gknd 3543 29 humans human NNS cord-010119-t1x9gknd 3543 30 . . . cord-010119-t1x9gknd 3544 1 In in IN cord-010119-t1x9gknd 3544 2 mice mouse NNS cord-010119-t1x9gknd 3544 3 , , , cord-010119-t1x9gknd 3544 4 mean mean VBP cord-010119-t1x9gknd 3544 5 recoveries recovery NNS cord-010119-t1x9gknd 3544 6 of of IN cord-010119-t1x9gknd 3544 7 the the DT cord-010119-t1x9gknd 3544 8 same same JJ cord-010119-t1x9gknd 3544 9 PLTs plt NNS cord-010119-t1x9gknd 3544 10 were be VBD cord-010119-t1x9gknd 3544 11 24.9 24.9 CD cord-010119-t1x9gknd 3544 12 6 6 CD cord-010119-t1x9gknd 3544 13 10.3 10.3 CD cord-010119-t1x9gknd 3544 14 % % NN cord-010119-t1x9gknd 3544 15 for for IN cord-010119-t1x9gknd 3544 16 RT RT NNP cord-010119-t1x9gknd 3544 17 , , , cord-010119-t1x9gknd 3544 18 19.1 19.1 CD cord-010119-t1x9gknd 3544 19 6 6 CD cord-010119-t1x9gknd 3544 20 9.8 9.8 CD cord-010119-t1x9gknd 3544 21 % % NN cord-010119-t1x9gknd 3544 22 for for IN cord-010119-t1x9gknd 3544 23 CT CT NNP cord-010119-t1x9gknd 3544 24 and and CC cord-010119-t1x9gknd 3544 25 16.2 16.2 CD cord-010119-t1x9gknd 3544 26 6 6 CD cord-010119-t1x9gknd 3544 27 6.9 6.9 CD cord-010119-t1x9gknd 3544 28 for for IN cord-010119-t1x9gknd 3544 29 CT CT NNP cord-010119-t1x9gknd 3544 30 ( ( -LRB- cord-010119-t1x9gknd 3544 31 mean6SD mean6sd NN cord-010119-t1x9gknd 3544 32 ) ) -RRB- cord-010119-t1x9gknd 3544 33 . . . cord-010119-t1x9gknd 3545 1 To to TO cord-010119-t1x9gknd 3545 2 compare compare VB cord-010119-t1x9gknd 3545 3 performance performance NN cord-010119-t1x9gknd 3545 4 of of IN cord-010119-t1x9gknd 3545 5 the the DT cord-010119-t1x9gknd 3545 6 PLTs plt NNS cord-010119-t1x9gknd 3545 7 in in IN cord-010119-t1x9gknd 3545 8 humans human NNS cord-010119-t1x9gknd 3545 9 and and CC cord-010119-t1x9gknd 3545 10 mice mouse NNS cord-010119-t1x9gknd 3545 11 we -PRON- PRP cord-010119-t1x9gknd 3545 12 expressed express VBD cord-010119-t1x9gknd 3545 13 all all DT cord-010119-t1x9gknd 3545 14 recoveries recovery NNS cord-010119-t1x9gknd 3545 15 as as IN cord-010119-t1x9gknd 3545 16 a a DT cord-010119-t1x9gknd 3545 17 percentage percentage NN cord-010119-t1x9gknd 3545 18 of of IN cord-010119-t1x9gknd 3545 19 the the DT cord-010119-t1x9gknd 3545 20 RT RT NNP cord-010119-t1x9gknd 3545 21 recoveries recovery NNS cord-010119-t1x9gknd 3545 22 . . . cord-010119-t1x9gknd 3546 1 In in IN cord-010119-t1x9gknd 3546 2 humans human NNS cord-010119-t1x9gknd 3546 3 TC TC NNP cord-010119-t1x9gknd 3546 4 was be VBD cord-010119-t1x9gknd 3546 5 $ $ $ cord-010119-t1x9gknd 3546 6 74 74 CD cord-010119-t1x9gknd 3546 7 % % NN cord-010119-t1x9gknd 3546 8 and and CC cord-010119-t1x9gknd 3546 9 CT CT NNP cord-010119-t1x9gknd 3546 10 was be VBD cord-010119-t1x9gknd 3546 11 $ $ $ cord-010119-t1x9gknd 3546 12 45 45 CD cord-010119-t1x9gknd 3546 13 % % NN cord-010119-t1x9gknd 3546 14 of of IN cord-010119-t1x9gknd 3546 15 RT RT NNP cord-010119-t1x9gknd 3546 16 . . . cord-010119-t1x9gknd 3547 1 In in IN cord-010119-t1x9gknd 3547 2 mice mouse NNS cord-010119-t1x9gknd 3547 3 TC TC NNP cord-010119-t1x9gknd 3547 4 was be VBD cord-010119-t1x9gknd 3547 5 $ $ $ cord-010119-t1x9gknd 3547 6 76 76 CD cord-010119-t1x9gknd 3547 7 % % NN cord-010119-t1x9gknd 3548 1 and and CC cord-010119-t1x9gknd 3548 2 CT CT NNP cord-010119-t1x9gknd 3548 3 was be VBD cord-010119-t1x9gknd 3548 4 $ $ $ cord-010119-t1x9gknd 3548 5 64 64 CD cord-010119-t1x9gknd 3548 6 % % NN cord-010119-t1x9gknd 3548 7 of of IN cord-010119-t1x9gknd 3548 8 RT RT NNP cord-010119-t1x9gknd 3548 9 . . . cord-010119-t1x9gknd 3549 1 The the DT cord-010119-t1x9gknd 3549 2 area area NN cord-010119-t1x9gknd 3549 3 under under IN cord-010119-t1x9gknd 3549 4 the the DT cord-010119-t1x9gknd 3549 5 survival survival NN cord-010119-t1x9gknd 3549 6 curve curve NN cord-010119-t1x9gknd 3549 7 ( ( -LRB- cord-010119-t1x9gknd 3549 8 AUC AUC NNP cord-010119-t1x9gknd 3549 9 ) ) -RRB- cord-010119-t1x9gknd 3549 10 was be VBD cord-010119-t1x9gknd 3549 11 calculated calculate VBN cord-010119-t1x9gknd 3549 12 for for IN cord-010119-t1x9gknd 3549 13 the the DT cord-010119-t1x9gknd 3549 14 individual individual JJ cord-010119-t1x9gknd 3549 15 mouse mouse NN cord-010119-t1x9gknd 3549 16 study study NN cord-010119-t1x9gknd 3549 17 and and CC cord-010119-t1x9gknd 3549 18 human human JJ cord-010119-t1x9gknd 3549 19 trial trial NN cord-010119-t1x9gknd 3549 20 data data NN cord-010119-t1x9gknd 3549 21 sets set NNS cord-010119-t1x9gknd 3549 22 . . . cord-010119-t1x9gknd 3550 1 The the DT cord-010119-t1x9gknd 3550 2 results result NNS cord-010119-t1x9gknd 3550 3 of of IN cord-010119-t1x9gknd 3550 4 both both CC cord-010119-t1x9gknd 3550 5 AUC AUC NNP cord-010119-t1x9gknd 3550 6 were be VBD cord-010119-t1x9gknd 3550 7 normalized normalize VBN cord-010119-t1x9gknd 3550 8 to to IN cord-010119-t1x9gknd 3550 9 100 100 CD cord-010119-t1x9gknd 3550 10 % % NN cord-010119-t1x9gknd 3550 11 for for IN cord-010119-t1x9gknd 3550 12 RT RT NNP cord-010119-t1x9gknd 3550 13 PLTs plt NNS cord-010119-t1x9gknd 3550 14 . . . cord-010119-t1x9gknd 3551 1 Human human JJ cord-010119-t1x9gknd 3551 2 TC TC NNP cord-010119-t1x9gknd 3551 3 PLTs PLTs NNP cord-010119-t1x9gknd 3551 4 had have VBD cord-010119-t1x9gknd 3551 5 26 26 CD cord-010119-t1x9gknd 3551 6 % % NN cord-010119-t1x9gknd 3551 7 AUC AUC NNP cord-010119-t1x9gknd 3551 8 while while IN cord-010119-t1x9gknd 3551 9 CT CT NNP cord-010119-t1x9gknd 3551 10 PLTs PLTs NNP cord-010119-t1x9gknd 3551 11 had have VBD cord-010119-t1x9gknd 3551 12 11 11 CD cord-010119-t1x9gknd 3551 13 % % NN cord-010119-t1x9gknd 3551 14 AUC auc NN cord-010119-t1x9gknd 3551 15 compared compare VBN cord-010119-t1x9gknd 3551 16 to to IN cord-010119-t1x9gknd 3551 17 RT RT NNP cord-010119-t1x9gknd 3551 18 PLTs plt NNS cord-010119-t1x9gknd 3551 19 in in IN cord-010119-t1x9gknd 3551 20 humans human NNS cord-010119-t1x9gknd 3551 21 . . . cord-010119-t1x9gknd 3552 1 In in IN cord-010119-t1x9gknd 3552 2 comparison comparison NN cord-010119-t1x9gknd 3552 3 , , , cord-010119-t1x9gknd 3552 4 the the DT cord-010119-t1x9gknd 3552 5 same same JJ cord-010119-t1x9gknd 3552 6 TC TC NNP cord-010119-t1x9gknd 3552 7 PLTs PLTs NNP cord-010119-t1x9gknd 3552 8 had have VBD cord-010119-t1x9gknd 3552 9 39 39 CD cord-010119-t1x9gknd 3552 10 % % NN cord-010119-t1x9gknd 3552 11 AUC AUC NNP cord-010119-t1x9gknd 3552 12 and and CC cord-010119-t1x9gknd 3552 13 CT CT NNP cord-010119-t1x9gknd 3552 14 PLTs PLTs NNP cord-010119-t1x9gknd 3552 15 had have VBD cord-010119-t1x9gknd 3552 16 26 26 CD cord-010119-t1x9gknd 3552 17 % % NN cord-010119-t1x9gknd 3552 18 AUC AUC NNP cord-010119-t1x9gknd 3552 19 of of IN cord-010119-t1x9gknd 3552 20 the the DT cord-010119-t1x9gknd 3552 21 RT RT NNP cord-010119-t1x9gknd 3552 22 AUC AUC NNP cord-010119-t1x9gknd 3552 23 in in IN cord-010119-t1x9gknd 3552 24 the the DT cord-010119-t1x9gknd 3552 25 mice mice NN cord-010119-t1x9gknd 3552 26 . . . cord-010119-t1x9gknd 3553 1 The the DT cord-010119-t1x9gknd 3553 2 calculated calculated JJ cord-010119-t1x9gknd 3553 3 ratios ratio NNS cord-010119-t1x9gknd 3553 4 of of IN cord-010119-t1x9gknd 3553 5 the the DT cord-010119-t1x9gknd 3553 6 AUC AUC NNP cord-010119-t1x9gknd 3553 7 between between IN cord-010119-t1x9gknd 3553 8 the the DT cord-010119-t1x9gknd 3553 9 TC TC NNP cord-010119-t1x9gknd 3553 10 PLTs PLTs NNP cord-010119-t1x9gknd 3553 11 and and CC cord-010119-t1x9gknd 3553 12 CT CT NNP cord-010119-t1x9gknd 3553 13 PLTs plt NNS cord-010119-t1x9gknd 3553 14 of of IN cord-010119-t1x9gknd 3553 15 the the DT cord-010119-t1x9gknd 3553 16 human human JJ cord-010119-t1x9gknd 3553 17 data datum NNS cord-010119-t1x9gknd 3553 18 set set NN cord-010119-t1x9gknd 3553 19 and and CC cord-010119-t1x9gknd 3553 20 mouse mouse NN cord-010119-t1x9gknd 3553 21 model model NN cord-010119-t1x9gknd 3553 22 data datum NNS cord-010119-t1x9gknd 3553 23 set set VBN cord-010119-t1x9gknd 3553 24 are be VBP cord-010119-t1x9gknd 3553 25 2.4 2.4 CD cord-010119-t1x9gknd 3553 26 and and CC cord-010119-t1x9gknd 3553 27 1.5 1.5 CD cord-010119-t1x9gknd 3553 28 , , , cord-010119-t1x9gknd 3553 29 respectively respectively RB cord-010119-t1x9gknd 3553 30 . . . cord-010119-t1x9gknd 3554 1 Conclusion conclusion NN cord-010119-t1x9gknd 3554 2 : : : cord-010119-t1x9gknd 3555 1 The the DT cord-010119-t1x9gknd 3555 2 SCID SCID NNP cord-010119-t1x9gknd 3555 3 mouse mouse NN cord-010119-t1x9gknd 3555 4 model model NN cord-010119-t1x9gknd 3555 5 differentiates differentiate VBZ cord-010119-t1x9gknd 3555 6 between between IN cord-010119-t1x9gknd 3555 7 RT RT NNP cord-010119-t1x9gknd 3555 8 PLTs PLTs NNP cord-010119-t1x9gknd 3555 9 and and CC cord-010119-t1x9gknd 3555 10 CT CT NNP cord-010119-t1x9gknd 3555 11 PLTs plt NNS cord-010119-t1x9gknd 3555 12 similar similar JJ cord-010119-t1x9gknd 3555 13 to to IN cord-010119-t1x9gknd 3555 14 humans human NNS cord-010119-t1x9gknd 3555 15 based base VBN cord-010119-t1x9gknd 3555 16 on on IN cord-010119-t1x9gknd 3555 17 AUC AUC NNP cord-010119-t1x9gknd 3555 18 and and CC cord-010119-t1x9gknd 3555 19 PLT PLT NNP cord-010119-t1x9gknd 3555 20 recovery recovery NN cord-010119-t1x9gknd 3555 21 data datum NNS cord-010119-t1x9gknd 3555 22 . . . cord-010119-t1x9gknd 3556 1 However however RB cord-010119-t1x9gknd 3556 2 , , , cord-010119-t1x9gknd 3556 3 the the DT cord-010119-t1x9gknd 3556 4 mouse mouse NN cord-010119-t1x9gknd 3556 5 model model NN cord-010119-t1x9gknd 3556 6 can can MD cord-010119-t1x9gknd 3556 7 not not RB cord-010119-t1x9gknd 3556 8 differentiate differentiate VB cord-010119-t1x9gknd 3556 9 between between IN cord-010119-t1x9gknd 3556 10 CT CT NNP cord-010119-t1x9gknd 3556 11 PLTs plt NNS cord-010119-t1x9gknd 3556 12 and and CC cord-010119-t1x9gknd 3556 13 TC TC NNP cord-010119-t1x9gknd 3556 14 PLTs PLTs NNP cord-010119-t1x9gknd 3556 15 as as IN cord-010119-t1x9gknd 3556 16 occurs occur VBZ cord-010119-t1x9gknd 3556 17 in in IN cord-010119-t1x9gknd 3556 18 humans human NNS cord-010119-t1x9gknd 3556 19 . . . cord-010119-t1x9gknd 3557 1 Even even RB cord-010119-t1x9gknd 3557 2 though though IN cord-010119-t1x9gknd 3557 3 the the DT cord-010119-t1x9gknd 3557 4 mouse mouse NN cord-010119-t1x9gknd 3557 5 model model NN cord-010119-t1x9gknd 3557 6 can can MD cord-010119-t1x9gknd 3557 7 not not RB cord-010119-t1x9gknd 3557 8 differentiate differentiate VB cord-010119-t1x9gknd 3557 9 between between IN cord-010119-t1x9gknd 3557 10 CT CT NNP cord-010119-t1x9gknd 3557 11 PLTs plt NNS cord-010119-t1x9gknd 3557 12 and and CC cord-010119-t1x9gknd 3557 13 TC TC NNP cord-010119-t1x9gknd 3557 14 PLTs PLTs NNP cord-010119-t1x9gknd 3557 15 , , , cord-010119-t1x9gknd 3557 16 it -PRON- PRP cord-010119-t1x9gknd 3557 17 may may MD cord-010119-t1x9gknd 3557 18 still still RB cord-010119-t1x9gknd 3557 19 be be VB cord-010119-t1x9gknd 3557 20 a a DT cord-010119-t1x9gknd 3557 21 useful useful JJ cord-010119-t1x9gknd 3557 22 tool tool NN cord-010119-t1x9gknd 3557 23 to to TO cord-010119-t1x9gknd 3557 24 screen screen VB cord-010119-t1x9gknd 3557 25 other other JJ cord-010119-t1x9gknd 3557 26 novel novel NN cord-010119-t1x9gknd 3557 27 storage storage NN cord-010119-t1x9gknd 3557 28 conditions condition NNS cord-010119-t1x9gknd 3557 29 for for IN cord-010119-t1x9gknd 3557 30 human human JJ cord-010119-t1x9gknd 3557 31 PLTs plt NNS cord-010119-t1x9gknd 3557 32 . . . cord-010119-t1x9gknd 3558 1 Converting convert VBG cord-010119-t1x9gknd 3558 2 the the DT cord-010119-t1x9gknd 3558 3 Component Component NNP cord-010119-t1x9gknd 3558 4 Manufacturing Manufacturing NNP cord-010119-t1x9gknd 3558 5 from from IN cord-010119-t1x9gknd 3558 6 a a DT cord-010119-t1x9gknd 3558 7 Manual Manual NNP cord-010119-t1x9gknd 3558 8 Process Process NNP cord-010119-t1x9gknd 3558 9 to to IN cord-010119-t1x9gknd 3558 10 Automation Automation NNP cord-010119-t1x9gknd 3558 11 Nicole Nicole NNP cord-010119-t1x9gknd 3558 12 Peters Peters NNP cord-010119-t1x9gknd 3559 1 * * NFP cord-010119-t1x9gknd 3559 2 1 1 CD cord-010119-t1x9gknd 3559 3 and and CC cord-010119-t1x9gknd 3559 4 Geeta Geeta NNP cord-010119-t1x9gknd 3559 5 Paranjape Paranjape NNP cord-010119-t1x9gknd 3559 6 1,2 1,2 CD cord-010119-t1x9gknd 3559 7 . . . cord-010119-t1x9gknd 3560 1 1 1 LS cord-010119-t1x9gknd 3560 2 Coastal Coastal NNP cord-010119-t1x9gknd 3560 3 Bend Bend NNP cord-010119-t1x9gknd 3560 4 Blood Blood NNP cord-010119-t1x9gknd 3560 5 Center Center NNP cord-010119-t1x9gknd 3560 6 , , , cord-010119-t1x9gknd 3560 7 2 2 CD cord-010119-t1x9gknd 3560 8 Carter Carter NNP cord-010119-t1x9gknd 3560 9 Blood Blood NNP cord-010119-t1x9gknd 3560 10 Care Care NNP cord-010119-t1x9gknd 3560 11 Background Background NNP cord-010119-t1x9gknd 3560 12 / / SYM cord-010119-t1x9gknd 3560 13 Case Case NNP cord-010119-t1x9gknd 3560 14 Studies Studies NNPS cord-010119-t1x9gknd 3560 15 : : : cord-010119-t1x9gknd 3560 16 Initiatives initiative NNS cord-010119-t1x9gknd 3560 17 focused focus VBD cord-010119-t1x9gknd 3560 18 on on IN cord-010119-t1x9gknd 3560 19 improvements improvement NNS cord-010119-t1x9gknd 3560 20 to to IN cord-010119-t1x9gknd 3560 21 donor donor NN cord-010119-t1x9gknd 3560 22 collection collection NN cord-010119-t1x9gknd 3560 23 processes process NNS cord-010119-t1x9gknd 3560 24 drove drive VBD cord-010119-t1x9gknd 3560 25 us -PRON- PRP cord-010119-t1x9gknd 3560 26 to to TO cord-010119-t1x9gknd 3560 27 investigate investigate VB cord-010119-t1x9gknd 3560 28 opportunities opportunity NNS cord-010119-t1x9gknd 3560 29 in in IN cord-010119-t1x9gknd 3560 30 our -PRON- PRP$ cord-010119-t1x9gknd 3560 31 component component NN cord-010119-t1x9gknd 3560 32 manufacturing manufacturing NN cord-010119-t1x9gknd 3560 33 processes process NNS cord-010119-t1x9gknd 3560 34 . . . cord-010119-t1x9gknd 3561 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3561 2 goal goal NN cord-010119-t1x9gknd 3561 3 was be VBD cord-010119-t1x9gknd 3561 4 to to TO cord-010119-t1x9gknd 3561 5 maintain maintain VB cord-010119-t1x9gknd 3561 6 blood blood NN cord-010119-t1x9gknd 3561 7 quality quality NN cord-010119-t1x9gknd 3561 8 while while IN cord-010119-t1x9gknd 3561 9 streamlining streamline VBG cord-010119-t1x9gknd 3561 10 manufacturing manufacture VBG cord-010119-t1x9gknd 3561 11 and and CC cord-010119-t1x9gknd 3561 12 automating automate VBG cord-010119-t1x9gknd 3561 13 the the DT cord-010119-t1x9gknd 3561 14 in in IN cord-010119-t1x9gknd 3561 15 - - HYPH cord-010119-t1x9gknd 3561 16 process process NN cord-010119-t1x9gknd 3561 17 documentation documentation NN cord-010119-t1x9gknd 3561 18 . . . cord-010119-t1x9gknd 3562 1 The the DT cord-010119-t1x9gknd 3562 2 CompoMat CompoMat NNP cord-010119-t1x9gknd 3562 3 G5 G5 NNP cord-010119-t1x9gknd 3562 4 was be VBD cord-010119-t1x9gknd 3562 5 evaluated evaluate VBN cord-010119-t1x9gknd 3562 6 using use VBG cord-010119-t1x9gknd 3562 7 a a DT cord-010119-t1x9gknd 3562 8 multi multi JJ cord-010119-t1x9gknd 3562 9 - - JJ cord-010119-t1x9gknd 3562 10 team team NN cord-010119-t1x9gknd 3562 11 approach approach NN cord-010119-t1x9gknd 3562 12 including include VBG cord-010119-t1x9gknd 3562 13 component component NN cord-010119-t1x9gknd 3562 14 manufacturing manufacturing NN cord-010119-t1x9gknd 3562 15 staff staff NN cord-010119-t1x9gknd 3562 16 , , , cord-010119-t1x9gknd 3562 17 equipment equipment NN cord-010119-t1x9gknd 3562 18 management management NN cord-010119-t1x9gknd 3562 19 , , , cord-010119-t1x9gknd 3562 20 QA QA NNP cord-010119-t1x9gknd 3562 21 , , , cord-010119-t1x9gknd 3562 22 Regulatory Regulatory NNP cord-010119-t1x9gknd 3562 23 Affairs Affairs NNPS cord-010119-t1x9gknd 3562 24 and and CC cord-010119-t1x9gknd 3562 25 IT IT NNP cord-010119-t1x9gknd 3562 26 . . . cord-010119-t1x9gknd 3563 1 Study Study NNP cord-010119-t1x9gknd 3563 2 Design Design NNP cord-010119-t1x9gknd 3563 3 / / SYM cord-010119-t1x9gknd 3563 4 Method method NN cord-010119-t1x9gknd 3563 5 : : : cord-010119-t1x9gknd 3563 6 After after IN cord-010119-t1x9gknd 3563 7 a a DT cord-010119-t1x9gknd 3563 8 comprehensive comprehensive JJ cord-010119-t1x9gknd 3563 9 evaluation evaluation NN cord-010119-t1x9gknd 3563 10 , , , cord-010119-t1x9gknd 3563 11 the the DT cord-010119-t1x9gknd 3563 12 team team NN cord-010119-t1x9gknd 3563 13 decided decide VBD cord-010119-t1x9gknd 3563 14 to to TO cord-010119-t1x9gknd 3563 15 purchase purchase VB cord-010119-t1x9gknd 3563 16 the the DT cord-010119-t1x9gknd 3563 17 CompoMat CompoMat NNP cord-010119-t1x9gknd 3563 18 G5 G5 NNP cord-010119-t1x9gknd 3563 19 with with IN cord-010119-t1x9gknd 3563 20 the the DT cord-010119-t1x9gknd 3563 21 CompoMaster CompoMaster NNP cord-010119-t1x9gknd 3563 22 Net Net NNP cord-010119-t1x9gknd 3563 23 Software Software NNP cord-010119-t1x9gknd 3563 24 for for IN cord-010119-t1x9gknd 3563 25 data datum NNS cord-010119-t1x9gknd 3563 26 management management NN cord-010119-t1x9gknd 3563 27 . . . cord-010119-t1x9gknd 3564 1 Implementation implementation NN cord-010119-t1x9gknd 3564 2 was be VBD cord-010119-t1x9gknd 3564 3 planned plan VBN cord-010119-t1x9gknd 3564 4 for for IN cord-010119-t1x9gknd 3564 5 a a DT cord-010119-t1x9gknd 3564 6 November November NNP cord-010119-t1x9gknd 3564 7 2014 2014 CD cord-010119-t1x9gknd 3564 8 go go VB cord-010119-t1x9gknd 3564 9 - - HYPH cord-010119-t1x9gknd 3564 10 live live NN cord-010119-t1x9gknd 3564 11 . . . cord-010119-t1x9gknd 3564 12 . . . cord-010119-t1x9gknd 3565 1 To to TO cord-010119-t1x9gknd 3565 2 centralize centralize VB cord-010119-t1x9gknd 3565 3 processing processing NN cord-010119-t1x9gknd 3565 4 , , , cord-010119-t1x9gknd 3565 5 new new JJ cord-010119-t1x9gknd 3565 6 work work NN cord-010119-t1x9gknd 3565 7 counters counter NNS cord-010119-t1x9gknd 3565 8 were be VBD cord-010119-t1x9gknd 3565 9 installed instal VBN cord-010119-t1x9gknd 3565 10 . . . cord-010119-t1x9gknd 3566 1 Fresenius Fresenius NNP cord-010119-t1x9gknd 3566 2 Kabi Kabi NNP cord-010119-t1x9gknd 3566 3 installed instal VBD cord-010119-t1x9gknd 3566 4 the the DT cord-010119-t1x9gknd 3566 5 CompoMat CompoMat NNP cord-010119-t1x9gknd 3566 6 G5s G5s NNP cord-010119-t1x9gknd 3566 7 and and CC cord-010119-t1x9gknd 3566 8 CompoMaster CompoMaster NNP cord-010119-t1x9gknd 3566 9 in in IN cord-010119-t1x9gknd 3566 10 June June NNP cord-010119-t1x9gknd 3566 11 2014 2014 CD cord-010119-t1x9gknd 3566 12 . . . cord-010119-t1x9gknd 3567 1 Training training NN cord-010119-t1x9gknd 3567 2 and and CC cord-010119-t1x9gknd 3567 3 validations validation NNS cord-010119-t1x9gknd 3567 4 were be VBD cord-010119-t1x9gknd 3567 5 successfully successfully RB cord-010119-t1x9gknd 3567 6 completed complete VBN cord-010119-t1x9gknd 3567 7 and and CC cord-010119-t1x9gknd 3567 8 a a DT cord-010119-t1x9gknd 3567 9 full full JJ cord-010119-t1x9gknd 3567 10 launch launch NN cord-010119-t1x9gknd 3567 11 occurred occur VBD cord-010119-t1x9gknd 3567 12 mid mid NNP cord-010119-t1x9gknd 3567 13 - - NNP cord-010119-t1x9gknd 3567 14 March March NNP cord-010119-t1x9gknd 3567 15 2015 2015 CD cord-010119-t1x9gknd 3567 16 . . . cord-010119-t1x9gknd 3568 1 Device device NN cord-010119-t1x9gknd 3568 2 and and CC cord-010119-t1x9gknd 3568 3 SOP sop NN cord-010119-t1x9gknd 3568 4 training training NN cord-010119-t1x9gknd 3568 5 was be VBD cord-010119-t1x9gknd 3568 6 performed perform VBN cord-010119-t1x9gknd 3568 7 . . . cord-010119-t1x9gknd 3569 1 Training training NN cord-010119-t1x9gknd 3569 2 Qualification qualification NN cord-010119-t1x9gknd 3569 3 Checklists Checklists NNPS cord-010119-t1x9gknd 3569 4 were be VBD cord-010119-t1x9gknd 3569 5 completed complete VBN cord-010119-t1x9gknd 3569 6 for for IN cord-010119-t1x9gknd 3569 7 each each DT cord-010119-t1x9gknd 3569 8 technician technician NN cord-010119-t1x9gknd 3569 9 with with IN cord-010119-t1x9gknd 3569 10 a a DT cord-010119-t1x9gknd 3569 11 required require VBN cord-010119-t1x9gknd 3569 12 number number NN cord-010119-t1x9gknd 3569 13 of of IN cord-010119-t1x9gknd 3569 14 successful successful JJ cord-010119-t1x9gknd 3569 15 units unit NNS cord-010119-t1x9gknd 3569 16 processed process VBN cord-010119-t1x9gknd 3569 17 and and CC cord-010119-t1x9gknd 3569 18 completed complete VBN cord-010119-t1x9gknd 3569 19 December December NNP cord-010119-t1x9gknd 3569 20 2014 2014 CD cord-010119-t1x9gknd 3569 21 . . . cord-010119-t1x9gknd 3570 1 Validation validation NN cord-010119-t1x9gknd 3570 2 was be VBD cord-010119-t1x9gknd 3570 3 completed complete VBN cord-010119-t1x9gknd 3570 4 and and CC cord-010119-t1x9gknd 3570 5 signed sign VBN cord-010119-t1x9gknd 3570 6 off off RP cord-010119-t1x9gknd 3570 7 in in IN cord-010119-t1x9gknd 3570 8 March March NNP cord-010119-t1x9gknd 3570 9 of of IN cord-010119-t1x9gknd 3570 10 2015 2015 CD cord-010119-t1x9gknd 3570 11 . . . cord-010119-t1x9gknd 3571 1 Manufacturing manufacturing NN cord-010119-t1x9gknd 3571 2 data datum NNS cord-010119-t1x9gknd 3571 3 was be VBD cord-010119-t1x9gknd 3571 4 collected collect VBN cord-010119-t1x9gknd 3571 5 using use VBG cord-010119-t1x9gknd 3571 6 the the DT cord-010119-t1x9gknd 3571 7 CompoMaster CompoMaster NNP cord-010119-t1x9gknd 3571 8 Net Net NNP cord-010119-t1x9gknd 3571 9 data data NN cord-010119-t1x9gknd 3571 10 management management NN cord-010119-t1x9gknd 3571 11 system system NN cord-010119-t1x9gknd 3571 12 and and CC cord-010119-t1x9gknd 3571 13 our -PRON- PRP$ cord-010119-t1x9gknd 3571 14 Quality Quality NNP cord-010119-t1x9gknd 3571 15 Control Control NNP cord-010119-t1x9gknd 3571 16 Software Software NNP cord-010119-t1x9gknd 3571 17 for for IN cord-010119-t1x9gknd 3571 18 Platelet platelet NN cord-010119-t1x9gknd 3571 19 ( ( -LRB- cord-010119-t1x9gknd 3571 20 PLT PLT NNP cord-010119-t1x9gknd 3571 21 ) ) -RRB- cord-010119-t1x9gknd 3571 22 parameters parameter NNS cord-010119-t1x9gknd 3571 23 , , , cord-010119-t1x9gknd 3571 24 including include VBG cord-010119-t1x9gknd 3571 25 PLT PLT NNP cord-010119-t1x9gknd 3571 26 count count NN cord-010119-t1x9gknd 3571 27 , , , cord-010119-t1x9gknd 3571 28 PLT PLT NNP cord-010119-t1x9gknd 3571 29 weight weight NN cord-010119-t1x9gknd 3571 30 , , , cord-010119-t1x9gknd 3571 31 and and CC cord-010119-t1x9gknd 3571 32 PLT PLT NNP cord-010119-t1x9gknd 3571 33 yield yield NN cord-010119-t1x9gknd 3571 34 from from IN cord-010119-t1x9gknd 3571 35 before before IN cord-010119-t1x9gknd 3571 36 implementation implementation NN cord-010119-t1x9gknd 3571 37 ( ( -LRB- cord-010119-t1x9gknd 3571 38 BI BI NNP cord-010119-t1x9gknd 3571 39 ) ) -RRB- cord-010119-t1x9gknd 3571 40 and and CC cord-010119-t1x9gknd 3571 41 after after IN cord-010119-t1x9gknd 3571 42 implementing implement VBG cord-010119-t1x9gknd 3571 43 ( ( -LRB- cord-010119-t1x9gknd 3571 44 AI AI NNP cord-010119-t1x9gknd 3571 45 ) ) -RRB- cord-010119-t1x9gknd 3571 46 of of IN cord-010119-t1x9gknd 3571 47 the the DT cord-010119-t1x9gknd 3571 48 CompoMat CompoMat NNP cord-010119-t1x9gknd 3571 49 G5 G5 NNP cord-010119-t1x9gknd 3571 50 system system NN cord-010119-t1x9gknd 3571 51 . . . cord-010119-t1x9gknd 3572 1 Data data NN cord-010119-t1x9gknd 3572 2 points point NNS cord-010119-t1x9gknd 3572 3 were be VBD cord-010119-t1x9gknd 3572 4 collected collect VBN cord-010119-t1x9gknd 3572 5 from from IN cord-010119-t1x9gknd 3572 6 210 210 CD cord-010119-t1x9gknd 3572 7 units unit NNS cord-010119-t1x9gknd 3572 8 BI BI NNP cord-010119-t1x9gknd 3572 9 and and CC cord-010119-t1x9gknd 3572 10 302 302 CD cord-010119-t1x9gknd 3572 11 units unit NNS cord-010119-t1x9gknd 3572 12 AI AI NNP cord-010119-t1x9gknd 3572 13 . . . cord-010119-t1x9gknd 3573 1 Results result NNS cord-010119-t1x9gknd 3573 2 / / SYM cord-010119-t1x9gknd 3573 3 Finding finding NN cord-010119-t1x9gknd 3573 4 : : : cord-010119-t1x9gknd 3573 5 Upon upon IN cord-010119-t1x9gknd 3573 6 initial initial JJ cord-010119-t1x9gknd 3573 7 implementation implementation NN cord-010119-t1x9gknd 3573 8 , , , cord-010119-t1x9gknd 3573 9 staff staff NN cord-010119-t1x9gknd 3573 10 training training NN cord-010119-t1x9gknd 3573 11 and and CC cord-010119-t1x9gknd 3573 12 use use NN cord-010119-t1x9gknd 3573 13 , , , cord-010119-t1x9gknd 3573 14 the the DT cord-010119-t1x9gknd 3573 15 CompoMat CompoMat NNP cord-010119-t1x9gknd 3573 16 G5 G5 NNP cord-010119-t1x9gknd 3573 17 was be VBD cord-010119-t1x9gknd 3573 18 found find VBN cord-010119-t1x9gknd 3573 19 to to TO cord-010119-t1x9gknd 3573 20 be be VB cord-010119-t1x9gknd 3573 21 easy easy JJ cord-010119-t1x9gknd 3573 22 . . . cord-010119-t1x9gknd 3574 1 PLT PLT NNP cord-010119-t1x9gknd 3574 2 weight weight NN cord-010119-t1x9gknd 3574 3 spread spread NN cord-010119-t1x9gknd 3574 4 was be VBD cord-010119-t1x9gknd 3574 5 reduced reduce VBN cord-010119-t1x9gknd 3574 6 from from IN cord-010119-t1x9gknd 3574 7 an an DT cord-010119-t1x9gknd 3574 8 average average NN cord-010119-t1x9gknd 3574 9 of of IN cord-010119-t1x9gknd 3574 10 22gm 22gm NN cord-010119-t1x9gknd 3574 11 to to IN cord-010119-t1x9gknd 3574 12 an an DT cord-010119-t1x9gknd 3574 13 average average NN cord-010119-t1x9gknd 3574 14 of of IN cord-010119-t1x9gknd 3574 15 15 15 CD cord-010119-t1x9gknd 3574 16 gm gm NNP cord-010119-t1x9gknd 3574 17 . . . cord-010119-t1x9gknd 3575 1 Actual actual JJ cord-010119-t1x9gknd 3575 2 PLT PLT NNP cord-010119-t1x9gknd 3575 3 weights weight NNS cord-010119-t1x9gknd 3575 4 were be VBD cord-010119-t1x9gknd 3575 5 reduced reduce VBN cord-010119-t1x9gknd 3575 6 from from IN cord-010119-t1x9gknd 3575 7 an an DT cord-010119-t1x9gknd 3575 8 average average NN cord-010119-t1x9gknd 3575 9 of of IN cord-010119-t1x9gknd 3575 10 63gm 63gm NN cord-010119-t1x9gknd 3575 11 to to IN cord-010119-t1x9gknd 3575 12 59gm 59gm NN cord-010119-t1x9gknd 3575 13 , , , cord-010119-t1x9gknd 3575 14 resulting result VBG cord-010119-t1x9gknd 3575 15 in in IN cord-010119-t1x9gknd 3575 16 an an DT cord-010119-t1x9gknd 3575 17 average average JJ cord-010119-t1x9gknd 3575 18 increase increase NN cord-010119-t1x9gknd 3575 19 in in IN cord-010119-t1x9gknd 3575 20 recovered recovered JJ cord-010119-t1x9gknd 3575 21 plasma plasma NN cord-010119-t1x9gknd 3575 22 of of IN cord-010119-t1x9gknd 3575 23 3.78ml 3.78ml CD cord-010119-t1x9gknd 3575 24 per per IN cord-010119-t1x9gknd 3575 25 unit unit NN cord-010119-t1x9gknd 3575 26 . . . cord-010119-t1x9gknd 3576 1 PLT PLT NNP cord-010119-t1x9gknd 3576 2 count count NN cord-010119-t1x9gknd 3576 3 on on IN cord-010119-t1x9gknd 3576 4 average average JJ cord-010119-t1x9gknd 3576 5 increased increase VBD cord-010119-t1x9gknd 3576 6 from from IN cord-010119-t1x9gknd 3576 7 a a DT cord-010119-t1x9gknd 3576 8 count count NN cord-010119-t1x9gknd 3576 9 of of IN cord-010119-t1x9gknd 3576 10 1435 1435 CD cord-010119-t1x9gknd 3576 11 to to IN cord-010119-t1x9gknd 3576 12 1506 1506 CD cord-010119-t1x9gknd 3576 13 ( ( -LRB- cord-010119-t1x9gknd 3576 14 10 10 CD cord-010119-t1x9gknd 3576 15 3 3 CD cord-010119-t1x9gknd 3576 16 /mm /mm CD cord-010119-t1x9gknd 3576 17 3 3 LS cord-010119-t1x9gknd 3576 18 ) ) -RRB- cord-010119-t1x9gknd 3576 19 with with IN cord-010119-t1x9gknd 3576 20 a a DT cord-010119-t1x9gknd 3576 21 negligible negligible JJ cord-010119-t1x9gknd 3576 22 change change NN cord-010119-t1x9gknd 3576 23 in in IN cord-010119-t1x9gknd 3576 24 PLT PLT NNP cord-010119-t1x9gknd 3576 25 Yield Yield NNP cord-010119-t1x9gknd 3576 26 . . . cord-010119-t1x9gknd 3577 1 Conclusion conclusion NN cord-010119-t1x9gknd 3577 2 : : : cord-010119-t1x9gknd 3577 3 PLT PLT NNP cord-010119-t1x9gknd 3577 4 weight weight NN cord-010119-t1x9gknd 3577 5 spread spread NN cord-010119-t1x9gknd 3577 6 was be VBD cord-010119-t1x9gknd 3577 7 reduced reduce VBN cord-010119-t1x9gknd 3577 8 by by IN cord-010119-t1x9gknd 3577 9 31.8 31.8 CD cord-010119-t1x9gknd 3577 10 % % NN cord-010119-t1x9gknd 3577 11 after after IN cord-010119-t1x9gknd 3577 12 implementation implementation NN cord-010119-t1x9gknd 3577 13 of of IN cord-010119-t1x9gknd 3577 14 the the DT cord-010119-t1x9gknd 3577 15 CompoMat CompoMat NNP cord-010119-t1x9gknd 3577 16 G5 G5 NNP cord-010119-t1x9gknd 3577 17 and and CC cord-010119-t1x9gknd 3577 18 our -PRON- PRP$ cord-010119-t1x9gknd 3577 19 PLT PLT NNP cord-010119-t1x9gknd 3577 20 concentrations concentration NNS cord-010119-t1x9gknd 3577 21 increased increase VBD cord-010119-t1x9gknd 3577 22 on on IN cord-010119-t1x9gknd 3577 23 average average JJ cord-010119-t1x9gknd 3577 24 by by IN cord-010119-t1x9gknd 3577 25 5 5 CD cord-010119-t1x9gknd 3577 26 % % NN cord-010119-t1x9gknd 3577 27 . . . cord-010119-t1x9gknd 3578 1 We -PRON- PRP cord-010119-t1x9gknd 3578 2 were be VBD cord-010119-t1x9gknd 3578 3 able able JJ cord-010119-t1x9gknd 3578 4 to to TO cord-010119-t1x9gknd 3578 5 consistently consistently RB cord-010119-t1x9gknd 3578 6 produce produce VB cord-010119-t1x9gknd 3578 7 a a DT cord-010119-t1x9gknd 3578 8 smaller small JJR cord-010119-t1x9gknd 3578 9 volume volume NN cord-010119-t1x9gknd 3578 10 PLT PLT NNP cord-010119-t1x9gknd 3578 11 ( ( -LRB- cord-010119-t1x9gknd 3578 12 average average JJ cord-010119-t1x9gknd 3578 13 59 59 CD cord-010119-t1x9gknd 3578 14 gm gm NNP cord-010119-t1x9gknd 3578 15 ) ) -RRB- cord-010119-t1x9gknd 3578 16 , , , cord-010119-t1x9gknd 3578 17 which which WDT cord-010119-t1x9gknd 3578 18 gave give VBD cord-010119-t1x9gknd 3578 19 us -PRON- PRP cord-010119-t1x9gknd 3578 20 3.78ml 3.78ml CD cord-010119-t1x9gknd 3578 21 more more JJR cord-010119-t1x9gknd 3578 22 plasma plasma NN cord-010119-t1x9gknd 3578 23 per per IN cord-010119-t1x9gknd 3578 24 unit unit NN cord-010119-t1x9gknd 3578 25 for for IN cord-010119-t1x9gknd 3578 26 recovered recovered JJ cord-010119-t1x9gknd 3578 27 plasma plasma NN cord-010119-t1x9gknd 3578 28 . . . cord-010119-t1x9gknd 3579 1 The the DT cord-010119-t1x9gknd 3579 2 team team NN cord-010119-t1x9gknd 3579 3 intends intend VBZ cord-010119-t1x9gknd 3579 4 to to TO cord-010119-t1x9gknd 3579 5 review review VB cord-010119-t1x9gknd 3579 6 a a DT cord-010119-t1x9gknd 3579 7 dryer dryer NN cord-010119-t1x9gknd 3579 8 Cryo Cryo NNP cord-010119-t1x9gknd 3579 9 as as IN cord-010119-t1x9gknd 3579 10 a a DT cord-010119-t1x9gknd 3579 11 next next JJ cord-010119-t1x9gknd 3579 12 step step NN cord-010119-t1x9gknd 3579 13 for for IN cord-010119-t1x9gknd 3579 14 potential potential JJ cord-010119-t1x9gknd 3579 15 additional additional JJ cord-010119-t1x9gknd 3579 16 plasma plasma NN cord-010119-t1x9gknd 3579 17 yields yield NNS cord-010119-t1x9gknd 3579 18 for for IN cord-010119-t1x9gknd 3579 19 recovered recovered JJ cord-010119-t1x9gknd 3579 20 plasma plasma NN cord-010119-t1x9gknd 3579 21 . . . cord-010119-t1x9gknd 3580 1 Deglycerolization deglycerolization NN cord-010119-t1x9gknd 3580 2 of of IN cord-010119-t1x9gknd 3580 3 Manually manually RB cord-010119-t1x9gknd 3580 4 Glycerolized Glycerolized NNP cord-010119-t1x9gknd 3580 5 , , , cord-010119-t1x9gknd 3580 6 Frozen Frozen NNP cord-010119-t1x9gknd 3580 7 Rccs Rccs NNP cord-010119-t1x9gknd 3580 8 Using use VBG cord-010119-t1x9gknd 3580 9 a a DT cord-010119-t1x9gknd 3580 10 Closed closed JJ cord-010119-t1x9gknd 3580 11 System system NN cord-010119-t1x9gknd 3580 12 Cell cell NN cord-010119-t1x9gknd 3580 13 Processor Processor NNP cord-010119-t1x9gknd 3580 14 Anita Anita NNP cord-010119-t1x9gknd 3580 15 Howell Howell NNP cord-010119-t1x9gknd 3580 16 1 1 CD cord-010119-t1x9gknd 3580 17 , , , cord-010119-t1x9gknd 3580 18 Angela Angela NNP cord-010119-t1x9gknd 3580 19 Hill Hill NNP cord-010119-t1x9gknd 3580 20 1 1 CD cord-010119-t1x9gknd 3580 21 , , , cord-010119-t1x9gknd 3580 22 Brandie Brandie NNP cord-010119-t1x9gknd 3580 23 Dennis Dennis NNP cord-010119-t1x9gknd 3580 24 2 2 CD cord-010119-t1x9gknd 3580 25 and and CC cord-010119-t1x9gknd 3580 26 Jason Jason NNP cord-010119-t1x9gknd 3580 27 P. P. NNP cord-010119-t1x9gknd 3580 28 Acker Acker NNP cord-010119-t1x9gknd 3580 29 * * NFP cord-010119-t1x9gknd 3580 30 2,3 2,3 CD cord-010119-t1x9gknd 3580 31 . . . cord-010119-t1x9gknd 3581 1 1 1 LS cord-010119-t1x9gknd 3582 1 Canadian Canadian NNP cord-010119-t1x9gknd 3582 2 Blood Blood NNP cord-010119-t1x9gknd 3582 3 Services Services NNPS cord-010119-t1x9gknd 3582 4 , , , cord-010119-t1x9gknd 3582 5 Centre Centre NNP cord-010119-t1x9gknd 3582 6 for for IN cord-010119-t1x9gknd 3582 7 Innovation Innovation NNP cord-010119-t1x9gknd 3582 8 , , , cord-010119-t1x9gknd 3582 9 2 2 CD cord-010119-t1x9gknd 3582 10 Canadian Canadian NNP cord-010119-t1x9gknd 3582 11 Blood Blood NNP cord-010119-t1x9gknd 3582 12 Services Services NNPS cord-010119-t1x9gknd 3582 13 , , , cord-010119-t1x9gknd 3582 14 3 3 CD cord-010119-t1x9gknd 3582 15 University University NNP cord-010119-t1x9gknd 3582 16 of of IN cord-010119-t1x9gknd 3582 17 Alberta Alberta NNP cord-010119-t1x9gknd 3582 18 Background Background NNP cord-010119-t1x9gknd 3582 19 / / SYM cord-010119-t1x9gknd 3582 20 Case Case NNP cord-010119-t1x9gknd 3582 21 Studies Studies NNPS cord-010119-t1x9gknd 3582 22 : : : cord-010119-t1x9gknd 3583 1 Upon upon IN cord-010119-t1x9gknd 3583 2 implementation implementation NN cord-010119-t1x9gknd 3583 3 of of IN cord-010119-t1x9gknd 3583 4 a a DT cord-010119-t1x9gknd 3583 5 closed closed JJ cord-010119-t1x9gknd 3583 6 system system NN cord-010119-t1x9gknd 3583 7 cell cell NN cord-010119-t1x9gknd 3583 8 processor processor NN cord-010119-t1x9gknd 3583 9 for for IN cord-010119-t1x9gknd 3583 10 glycerolization glycerolization NN cord-010119-t1x9gknd 3583 11 and and CC cord-010119-t1x9gknd 3583 12 deglycerolization deglycerolization NN cord-010119-t1x9gknd 3583 13 of of IN cord-010119-t1x9gknd 3583 14 red red JJ cord-010119-t1x9gknd 3583 15 cell cell NN cord-010119-t1x9gknd 3583 16 concentrates concentrate NNS cord-010119-t1x9gknd 3583 17 ( ( -LRB- cord-010119-t1x9gknd 3583 18 RCCs rccs NN cord-010119-t1x9gknd 3583 19 ) ) -RRB- cord-010119-t1x9gknd 3583 20 , , , cord-010119-t1x9gknd 3583 21 many many JJ cord-010119-t1x9gknd 3583 22 rare rare JJ cord-010119-t1x9gknd 3583 23 RCCs rcc NNS cord-010119-t1x9gknd 3583 24 frozen freeze VBN cord-010119-t1x9gknd 3583 25 using use VBG cord-010119-t1x9gknd 3583 26 the the DT cord-010119-t1x9gknd 3583 27 current current JJ cord-010119-t1x9gknd 3583 28 manual manual NN cord-010119-t1x9gknd 3583 29 , , , cord-010119-t1x9gknd 3583 30 open open JJ cord-010119-t1x9gknd 3583 31 system system NN cord-010119-t1x9gknd 3583 32 glycerolization glycerolization NN cord-010119-t1x9gknd 3583 33 method method NN cord-010119-t1x9gknd 3583 34 will will MD cord-010119-t1x9gknd 3583 35 remain remain VB cord-010119-t1x9gknd 3583 36 in in IN cord-010119-t1x9gknd 3583 37 the the DT cord-010119-t1x9gknd 3583 38 organization organization NN cord-010119-t1x9gknd 3583 39 's 's POS cord-010119-t1x9gknd 3583 40 frozen frozen JJ cord-010119-t1x9gknd 3583 41 inventory inventory NN cord-010119-t1x9gknd 3583 42 . . . cord-010119-t1x9gknd 3584 1 A a DT cord-010119-t1x9gknd 3584 2 study study NN cord-010119-t1x9gknd 3584 3 was be VBD cord-010119-t1x9gknd 3584 4 undertaken undertake VBN cord-010119-t1x9gknd 3584 5 to to TO cord-010119-t1x9gknd 3584 6 assess assess VB cord-010119-t1x9gknd 3584 7 the the DT cord-010119-t1x9gknd 3584 8 feasibility feasibility NN cord-010119-t1x9gknd 3584 9 of of IN cord-010119-t1x9gknd 3584 10 deglycerolizing deglycerolize VBG cord-010119-t1x9gknd 3584 11 this this DT cord-010119-t1x9gknd 3584 12 existing exist VBG cord-010119-t1x9gknd 3584 13 inventory inventory NN cord-010119-t1x9gknd 3584 14 on on IN cord-010119-t1x9gknd 3584 15 the the DT cord-010119-t1x9gknd 3584 16 closed closed JJ cord-010119-t1x9gknd 3584 17 cell cell NN cord-010119-t1x9gknd 3584 18 processor processor NN cord-010119-t1x9gknd 3584 19 and and CC cord-010119-t1x9gknd 3584 20 to to TO cord-010119-t1x9gknd 3584 21 evaluate evaluate VB cord-010119-t1x9gknd 3584 22 how how WRB cord-010119-t1x9gknd 3584 23 the the DT cord-010119-t1x9gknd 3584 24 change change NN cord-010119-t1x9gknd 3584 25 may may MD cord-010119-t1x9gknd 3584 26 impact impact VB cord-010119-t1x9gknd 3584 27 post post VB cord-010119-t1x9gknd 3584 28 - - JJ cord-010119-t1x9gknd 3584 29 thaw thaw JJ cord-010119-t1x9gknd 3584 30 red red JJ cord-010119-t1x9gknd 3584 31 blood blood NN cord-010119-t1x9gknd 3584 32 cell cell NN cord-010119-t1x9gknd 3584 33 ( ( -LRB- cord-010119-t1x9gknd 3584 34 RBC RBC NNP cord-010119-t1x9gknd 3584 35 ) ) -RRB- cord-010119-t1x9gknd 3584 36 in in IN cord-010119-t1x9gknd 3584 37 vitro vitro FW cord-010119-t1x9gknd 3584 38 quality quality NN cord-010119-t1x9gknd 3584 39 . . . cord-010119-t1x9gknd 3585 1 As as IN cord-010119-t1x9gknd 3585 2 the the DT cord-010119-t1x9gknd 3585 3 closed closed JJ cord-010119-t1x9gknd 3585 4 cell cell NN cord-010119-t1x9gknd 3585 5 processor processor NN cord-010119-t1x9gknd 3585 6 uses use VBZ cord-010119-t1x9gknd 3585 7 a a DT cord-010119-t1x9gknd 3585 8 fixed fix VBN cord-010119-t1x9gknd 3585 9 centrifuge centrifuge NN cord-010119-t1x9gknd 3585 10 bowl bowl NN cord-010119-t1x9gknd 3585 11 for for IN cord-010119-t1x9gknd 3585 12 deglycerolization deglycerolization NN cord-010119-t1x9gknd 3585 13 and and CC cord-010119-t1x9gknd 3585 14 RBC RBC NNP cord-010119-t1x9gknd 3585 15 resuspension resuspension NN cord-010119-t1x9gknd 3585 16 , , , cord-010119-t1x9gknd 3585 17 both both CC cord-010119-t1x9gknd 3585 18 large large JJ cord-010119-t1x9gknd 3585 19 and and CC cord-010119-t1x9gknd 3585 20 small small JJ cord-010119-t1x9gknd 3585 21 units unit NNS cord-010119-t1x9gknd 3585 22 were be VBD cord-010119-t1x9gknd 3585 23 assessed assess VBN cord-010119-t1x9gknd 3585 24 to to TO cord-010119-t1x9gknd 3585 25 determine determine VB cord-010119-t1x9gknd 3585 26 the the DT cord-010119-t1x9gknd 3585 27 impact impact NN cord-010119-t1x9gknd 3585 28 of of IN cord-010119-t1x9gknd 3585 29 cellular cellular JJ cord-010119-t1x9gknd 3585 30 loss loss NN cord-010119-t1x9gknd 3585 31 and and CC cord-010119-t1x9gknd 3585 32 variability variability NN cord-010119-t1x9gknd 3585 33 in in IN cord-010119-t1x9gknd 3585 34 hematocrit hematocrit NN cord-010119-t1x9gknd 3585 35 on on IN cord-010119-t1x9gknd 3585 36 the the DT cord-010119-t1x9gknd 3585 37 post post JJ cord-010119-t1x9gknd 3585 38 - - JJ cord-010119-t1x9gknd 3585 39 thaw thaw JJ cord-010119-t1x9gknd 3585 40 product product NN cord-010119-t1x9gknd 3585 41 . . . cord-010119-t1x9gknd 3586 1 Study Study NNP cord-010119-t1x9gknd 3586 2 Design Design NNP cord-010119-t1x9gknd 3586 3 / / SYM cord-010119-t1x9gknd 3586 4 Methods method NNS cord-010119-t1x9gknd 3586 5 : : : cord-010119-t1x9gknd 3586 6 13 13 CD cord-010119-t1x9gknd 3587 1 ABO ABO NNP cord-010119-t1x9gknd 3587 2 / / SYM cord-010119-t1x9gknd 3587 3 Rh Rh NNP cord-010119-t1x9gknd 3587 4 matched match VBD cord-010119-t1x9gknd 3587 5 LR LR NNP cord-010119-t1x9gknd 3587 6 SAGM SAGM NNP cord-010119-t1x9gknd 3587 7 RCCs rcc NNS cord-010119-t1x9gknd 3587 8 were be VBD cord-010119-t1x9gknd 3587 9 pooled pool VBN cord-010119-t1x9gknd 3587 10 and and CC cord-010119-t1x9gknd 3587 11 split split VBD cord-010119-t1x9gknd 3587 12 to to TO cord-010119-t1x9gknd 3587 13 produce produce VB cord-010119-t1x9gknd 3587 14 6 6 CD cord-010119-t1x9gknd 3587 15 large large JJ cord-010119-t1x9gknd 3587 16 ( ( -LRB- cord-010119-t1x9gknd 3587 17 354 354 CD cord-010119-t1x9gknd 3587 18 mL ml NN cord-010119-t1x9gknd 3587 19 ) ) -RRB- cord-010119-t1x9gknd 3587 20 and and CC cord-010119-t1x9gknd 3587 21 6 6 CD cord-010119-t1x9gknd 3587 22 small small JJ cord-010119-t1x9gknd 3587 23 ( ( -LRB- cord-010119-t1x9gknd 3587 24 244 244 CD cord-010119-t1x9gknd 3587 25 mL ml NN cord-010119-t1x9gknd 3587 26 ) ) -RRB- cord-010119-t1x9gknd 3587 27 RCCs rccs NN cord-010119-t1x9gknd 3587 28 . . . cord-010119-t1x9gknd 3588 1 The the DT cord-010119-t1x9gknd 3588 2 RCCs rcc NNS cord-010119-t1x9gknd 3588 3 were be VBD cord-010119-t1x9gknd 3588 4 stored store VBN cord-010119-t1x9gknd 3588 5 to to IN cord-010119-t1x9gknd 3588 6 14 14 CD cord-010119-t1x9gknd 3588 7 d d CD cord-010119-t1x9gknd 3588 8 and and CC cord-010119-t1x9gknd 3588 9 glycerolized glycerolize VBN cord-010119-t1x9gknd 3588 10 manually manually RB cord-010119-t1x9gknd 3588 11 by by IN cord-010119-t1x9gknd 3588 12 mixing mix VBG cord-010119-t1x9gknd 3588 13 400 400 CD cord-010119-t1x9gknd 3588 14 mL mL NNS cord-010119-t1x9gknd 3588 15 of of IN cord-010119-t1x9gknd 3588 16 glycerol glycerol NN cord-010119-t1x9gknd 3588 17 with with IN cord-010119-t1x9gknd 3588 18 the the DT cord-010119-t1x9gknd 3588 19 RCC RCC NNP cord-010119-t1x9gknd 3588 20 in in IN cord-010119-t1x9gknd 3588 21 a a DT cord-010119-t1x9gknd 3588 22 2000 2000 CD cord-010119-t1x9gknd 3588 23 mL ml NN cord-010119-t1x9gknd 3588 24 freezing freeze VBG cord-010119-t1x9gknd 3588 25 bag bag NN cord-010119-t1x9gknd 3588 26 . . . cord-010119-t1x9gknd 3589 1 Units unit NNS cord-010119-t1x9gknd 3589 2 were be VBD cord-010119-t1x9gknd 3589 3 frozen freeze VBN cord-010119-t1x9gknd 3589 4 at at IN cord-010119-t1x9gknd 3589 5 -658C -658c NN cord-010119-t1x9gknd 3589 6 for for IN cord-010119-t1x9gknd 3589 7 ! ! . cord-010119-t1x9gknd 3590 1 72 72 CD cord-010119-t1x9gknd 3590 2 h h NN cord-010119-t1x9gknd 3590 3 before before IN cord-010119-t1x9gknd 3590 4 being be VBG cord-010119-t1x9gknd 3590 5 removed remove VBN cord-010119-t1x9gknd 3590 6 from from IN cord-010119-t1x9gknd 3590 7 frozen frozen JJ cord-010119-t1x9gknd 3590 8 storage storage NN cord-010119-t1x9gknd 3590 9 and and CC cord-010119-t1x9gknd 3590 10 thawed thaw VBN cord-010119-t1x9gknd 3590 11 in in IN cord-010119-t1x9gknd 3590 12 a a DT cord-010119-t1x9gknd 3590 13 378C 378c CD cord-010119-t1x9gknd 3590 14 water water NN cord-010119-t1x9gknd 3590 15 bath bath NN cord-010119-t1x9gknd 3590 16 . . . cord-010119-t1x9gknd 3591 1 3 3 CD cord-010119-t1x9gknd 3591 2 large large JJ cord-010119-t1x9gknd 3591 3 RCCs rcc NNS cord-010119-t1x9gknd 3591 4 and and CC cord-010119-t1x9gknd 3591 5 3 3 CD cord-010119-t1x9gknd 3591 6 small small JJ cord-010119-t1x9gknd 3591 7 RCCs rcc NNS cord-010119-t1x9gknd 3591 8 were be VBD cord-010119-t1x9gknd 3591 9 deglycerolized deglycerolize VBN cord-010119-t1x9gknd 3591 10 using use VBG cord-010119-t1x9gknd 3591 11 the the DT cord-010119-t1x9gknd 3591 12 organization organization NN cord-010119-t1x9gknd 3591 13 's 's POS cord-010119-t1x9gknd 3591 14 current current JJ cord-010119-t1x9gknd 3591 15 procedure procedure NN cord-010119-t1x9gknd 3591 16 on on IN cord-010119-t1x9gknd 3591 17 the the DT cord-010119-t1x9gknd 3591 18 COBE COBE NNP cord-010119-t1x9gknd 3591 19 2991 2991 CD cord-010119-t1x9gknd 3591 20 cell cell NN cord-010119-t1x9gknd 3591 21 processor processor NN cord-010119-t1x9gknd 3591 22 prior prior RB cord-010119-t1x9gknd 3591 23 to to IN cord-010119-t1x9gknd 3591 24 re re NN cord-010119-t1x9gknd 3591 25 - - NN cord-010119-t1x9gknd 3591 26 suspension suspension NN cord-010119-t1x9gknd 3591 27 in in IN cord-010119-t1x9gknd 3591 28 0.9 0.9 CD cord-010119-t1x9gknd 3591 29 % % NN cord-010119-t1x9gknd 3591 30 saline saline NN cord-010119-t1x9gknd 3591 31 , , , cord-010119-t1x9gknd 3591 32 0.2 0.2 CD cord-010119-t1x9gknd 3591 33 % % NN cord-010119-t1x9gknd 3591 34 dextrose dextrose NN cord-010119-t1x9gknd 3591 35 . . . cord-010119-t1x9gknd 3592 1 The the DT cord-010119-t1x9gknd 3592 2 remaining remain VBG cord-010119-t1x9gknd 3592 3 RCCs rcc NNS cord-010119-t1x9gknd 3592 4 were be VBD cord-010119-t1x9gknd 3592 5 transferred transfer VBN cord-010119-t1x9gknd 3592 6 into into IN cord-010119-t1x9gknd 3592 7 a a DT cord-010119-t1x9gknd 3592 8 1L 1l CD cord-010119-t1x9gknd 3592 9 bag bag NN cord-010119-t1x9gknd 3592 10 , , , cord-010119-t1x9gknd 3592 11 spun spin VBD cord-010119-t1x9gknd 3592 12 to to TO cord-010119-t1x9gknd 3592 13 allow allow VB cord-010119-t1x9gknd 3592 14 removal removal NN cord-010119-t1x9gknd 3592 15 of of IN cord-010119-t1x9gknd 3592 16 excess excess JJ cord-010119-t1x9gknd 3592 17 glycerol glycerol NN cord-010119-t1x9gknd 3592 18 by by IN cord-010119-t1x9gknd 3592 19 manual manual JJ cord-010119-t1x9gknd 3592 20 extraction extraction NN cord-010119-t1x9gknd 3592 21 to to TO cord-010119-t1x9gknd 3592 22 achieve achieve VB cord-010119-t1x9gknd 3592 23 a a DT cord-010119-t1x9gknd 3592 24 hematocrit hematocrit NN cord-010119-t1x9gknd 3592 25 of of IN cord-010119-t1x9gknd 3592 26 75 75 CD cord-010119-t1x9gknd 3592 27 6 6 CD cord-010119-t1x9gknd 3592 28 5 5 CD cord-010119-t1x9gknd 3592 29 % % NN cord-010119-t1x9gknd 3592 30 , , , cord-010119-t1x9gknd 3592 31 and and CC cord-010119-t1x9gknd 3592 32 deglycerolized deglycerolize VBN cord-010119-t1x9gknd 3592 33 in in IN cord-010119-t1x9gknd 3592 34 a a DT cord-010119-t1x9gknd 3592 35 275 275 CD cord-010119-t1x9gknd 3592 36 mL ml NN cord-010119-t1x9gknd 3592 37 centrifuge centrifuge NN cord-010119-t1x9gknd 3592 38 bowl bowl NN cord-010119-t1x9gknd 3592 39 on on IN cord-010119-t1x9gknd 3592 40 the the DT cord-010119-t1x9gknd 3592 41 ACP-215 acp-215 NN cord-010119-t1x9gknd 3592 42 with with IN cord-010119-t1x9gknd 3592 43 re re NN cord-010119-t1x9gknd 3592 44 - - NN cord-010119-t1x9gknd 3592 45 suspension suspension NN cord-010119-t1x9gknd 3592 46 in in IN cord-010119-t1x9gknd 3592 47 AS-3 AS-3 NNP cord-010119-t1x9gknd 3592 48 . . . cord-010119-t1x9gknd 3593 1 RBC RBC NNP cord-010119-t1x9gknd 3593 2 quality quality NN cord-010119-t1x9gknd 3593 3 was be VBD cord-010119-t1x9gknd 3593 4 tested test VBN cord-010119-t1x9gknd 3593 5 at at IN cord-010119-t1x9gknd 3593 6 24 24 CD cord-010119-t1x9gknd 3593 7 6 6 CD cord-010119-t1x9gknd 3593 8 2 2 CD cord-010119-t1x9gknd 3593 9 h h NN cord-010119-t1x9gknd 3593 10 post post NN cord-010119-t1x9gknd 3593 11 - - NN cord-010119-t1x9gknd 3593 12 deglycerolization deglycerolization NN cord-010119-t1x9gknd 3593 13 . . . cord-010119-t1x9gknd 3594 1 Results/ Results/ . cord-010119-t1x9gknd 3595 1 Findings finding NNS cord-010119-t1x9gknd 3595 2 : : : cord-010119-t1x9gknd 3596 1 Large large JJ cord-010119-t1x9gknd 3596 2 RCCs rcc NNS cord-010119-t1x9gknd 3596 3 had have VBD cord-010119-t1x9gknd 3596 4 significantly significantly RB cord-010119-t1x9gknd 3596 5 higher high JJR cord-010119-t1x9gknd 3596 6 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3596 7 per per IN cord-010119-t1x9gknd 3596 8 unit unit NN cord-010119-t1x9gknd 3596 9 ( ( -LRB- cord-010119-t1x9gknd 3596 10 COBE COBE NNP cord-010119-t1x9gknd 3596 11 : : : cord-010119-t1x9gknd 3596 12 p50.006 p50.006 NNP cord-010119-t1x9gknd 3596 13 , , , cord-010119-t1x9gknd 3596 14 ACP215 acp215 NN cord-010119-t1x9gknd 3596 15 : : : cord-010119-t1x9gknd 3596 16 p50.007 p50.007 NN cord-010119-t1x9gknd 3596 17 ) ) -RRB- cord-010119-t1x9gknd 3596 18 and and CC cord-010119-t1x9gknd 3596 19 lower low JJR cord-010119-t1x9gknd 3596 20 cell cell NN cord-010119-t1x9gknd 3596 21 recovery recovery NN cord-010119-t1x9gknd 3596 22 ( ( -LRB- cord-010119-t1x9gknd 3596 23 COBE COBE NNP cord-010119-t1x9gknd 3596 24 : : : cord-010119-t1x9gknd 3596 25 p50.002 p50.002 UH cord-010119-t1x9gknd 3596 26 , , . cord-010119-t1x9gknd 3597 1 ACP215 ACP215 NNP cord-010119-t1x9gknd 3597 2 : : : cord-010119-t1x9gknd 3598 1 p<0.001 p<0.001 LS cord-010119-t1x9gknd 3598 2 ) ) -RRB- cord-010119-t1x9gknd 3598 3 post post JJ cord-010119-t1x9gknd 3598 4 - - JJ cord-010119-t1x9gknd 3598 5 deglycerolization deglycerolization NN cord-010119-t1x9gknd 3598 6 than than IN cord-010119-t1x9gknd 3598 7 smaller small JJR cord-010119-t1x9gknd 3598 8 RCCs rcc NNS cord-010119-t1x9gknd 3598 9 on on IN cord-010119-t1x9gknd 3598 10 both both DT cord-010119-t1x9gknd 3598 11 cell cell NN cord-010119-t1x9gknd 3598 12 processors processor NNS cord-010119-t1x9gknd 3598 13 . . . cord-010119-t1x9gknd 3599 1 Large large JJ cord-010119-t1x9gknd 3599 2 RCCs rcc NNS cord-010119-t1x9gknd 3599 3 deglycerolized deglycerolize VBN cord-010119-t1x9gknd 3599 4 on on IN cord-010119-t1x9gknd 3599 5 the the DT cord-010119-t1x9gknd 3599 6 COBE COBE NNP cord-010119-t1x9gknd 3599 7 2991 2991 CD cord-010119-t1x9gknd 3599 8 had have VBD cord-010119-t1x9gknd 3599 9 higher high JJR cord-010119-t1x9gknd 3599 10 hemolysis hemolysis NN cord-010119-t1x9gknd 3599 11 ( ( -LRB- cord-010119-t1x9gknd 3599 12 p<0.001 p<0.001 JJ cord-010119-t1x9gknd 3599 13 ) ) -RRB- cord-010119-t1x9gknd 3599 14 and and CC cord-010119-t1x9gknd 3599 15 supernatant supernatant JJ cord-010119-t1x9gknd 3599 16 potassium potassium NN cord-010119-t1x9gknd 3599 17 ( ( -LRB- cord-010119-t1x9gknd 3599 18 p50.001 p50.001 NNP cord-010119-t1x9gknd 3599 19 ) ) -RRB- cord-010119-t1x9gknd 3600 1 than than IN cord-010119-t1x9gknd 3600 2 did do VBD cord-010119-t1x9gknd 3600 3 small small JJ cord-010119-t1x9gknd 3600 4 volume volume NN cord-010119-t1x9gknd 3600 5 RCCs rcc NNS cord-010119-t1x9gknd 3600 6 . . . cord-010119-t1x9gknd 3601 1 Large large JJ cord-010119-t1x9gknd 3601 2 COBE COBE NNP cord-010119-t1x9gknd 3601 3 2991 2991 CD cord-010119-t1x9gknd 3601 4 RCCs rccs NN cord-010119-t1x9gknd 3601 5 had have VBD cord-010119-t1x9gknd 3601 6 higher high JJR cord-010119-t1x9gknd 3601 7 hematocrits hematocrit NNS cord-010119-t1x9gknd 3601 8 ( ( -LRB- cord-010119-t1x9gknd 3601 9 p50.033 p50.033 NNP cord-010119-t1x9gknd 3601 10 ) ) -RRB- cord-010119-t1x9gknd 3601 11 , , , cord-010119-t1x9gknd 3601 12 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3601 13 ( ( -LRB- cord-010119-t1x9gknd 3601 14 p50.006 p50.006 NNP cord-010119-t1x9gknd 3601 15 ) ) -RRB- cord-010119-t1x9gknd 3601 16 , , , cord-010119-t1x9gknd 3601 17 and and CC cord-010119-t1x9gknd 3601 18 recovery recovery NN cord-010119-t1x9gknd 3601 19 ( ( -LRB- cord-010119-t1x9gknd 3601 20 p50.001 p50.001 NNP cord-010119-t1x9gknd 3601 21 ) ) -RRB- cord-010119-t1x9gknd 3601 22 than than IN cord-010119-t1x9gknd 3601 23 did do VBD cord-010119-t1x9gknd 3601 24 large large JJ cord-010119-t1x9gknd 3601 25 ACP-215 acp-215 NN cord-010119-t1x9gknd 3601 26 RCCs rcc NNS cord-010119-t1x9gknd 3601 27 . . . cord-010119-t1x9gknd 3602 1 However however RB cord-010119-t1x9gknd 3602 2 , , , cord-010119-t1x9gknd 3602 3 all all DT cord-010119-t1x9gknd 3602 4 COBE COBE NNP cord-010119-t1x9gknd 3602 5 2991 2991 CD cord-010119-t1x9gknd 3602 6 RCCs rccs NN cord-010119-t1x9gknd 3602 7 had have VBD cord-010119-t1x9gknd 3602 8 higher high JJR cord-010119-t1x9gknd 3602 9 ( ( -LRB- cord-010119-t1x9gknd 3602 10 p<0.001 p<0.001 NNS cord-010119-t1x9gknd 3602 11 ) ) -RRB- cord-010119-t1x9gknd 3602 12 hemolysis hemolysis NN cord-010119-t1x9gknd 3602 13 ( ( -LRB- cord-010119-t1x9gknd 3602 14 0.99 0.99 CD cord-010119-t1x9gknd 3602 15 6 6 CD cord-010119-t1x9gknd 3602 16 0.24 0.24 CD cord-010119-t1x9gknd 3602 17 % % NN cord-010119-t1x9gknd 3602 18 ) ) -RRB- cord-010119-t1x9gknd 3602 19 levels level NNS cord-010119-t1x9gknd 3602 20 than than IN cord-010119-t1x9gknd 3602 21 did do VBD cord-010119-t1x9gknd 3602 22 ACP-215 acp-215 NN cord-010119-t1x9gknd 3602 23 RCCs rcc NNS cord-010119-t1x9gknd 3602 24 ( ( -LRB- cord-010119-t1x9gknd 3602 25 0.31 0.31 CD cord-010119-t1x9gknd 3602 26 6 6 CD cord-010119-t1x9gknd 3602 27 0.02 0.02 CD cord-010119-t1x9gknd 3602 28 % % NN cord-010119-t1x9gknd 3602 29 ) ) -RRB- cord-010119-t1x9gknd 3602 30 . . . cord-010119-t1x9gknd 3603 1 COBE COBE NNP cord-010119-t1x9gknd 3603 2 2991 2991 CD cord-010119-t1x9gknd 3603 3 RCCs rccs NN cord-010119-t1x9gknd 3603 4 failed fail VBD cord-010119-t1x9gknd 3603 5 to to TO cord-010119-t1x9gknd 3603 6 meet meet VB cord-010119-t1x9gknd 3603 7 regulatory regulatory JJ cord-010119-t1x9gknd 3603 8 hemolysis hemolysis NN cord-010119-t1x9gknd 3603 9 standards standard NNS cord-010119-t1x9gknd 3603 10 of of IN cord-010119-t1x9gknd 3603 11 0.8 0.8 CD cord-010119-t1x9gknd 3603 12 % % NN cord-010119-t1x9gknd 3603 13 . . . cord-010119-t1x9gknd 3604 1 Conclusion conclusion NN cord-010119-t1x9gknd 3604 2 : : : cord-010119-t1x9gknd 3604 3 Addition addition NN cord-010119-t1x9gknd 3604 4 of of IN cord-010119-t1x9gknd 3604 5 a a DT cord-010119-t1x9gknd 3604 6 400 400 CD cord-010119-t1x9gknd 3604 7 mL ml NN cord-010119-t1x9gknd 3604 8 bolus bolus NN cord-010119-t1x9gknd 3604 9 dose dose NN cord-010119-t1x9gknd 3604 10 of of IN cord-010119-t1x9gknd 3604 11 glycerol glycerol NN cord-010119-t1x9gknd 3604 12 to to IN cord-010119-t1x9gknd 3604 13 RCCs rcc NNS cord-010119-t1x9gknd 3604 14 of of IN cord-010119-t1x9gknd 3604 15 different different JJ cord-010119-t1x9gknd 3604 16 volumes volume NNS cord-010119-t1x9gknd 3604 17 results result NNS cord-010119-t1x9gknd 3604 18 in in IN cord-010119-t1x9gknd 3604 19 different different JJ cord-010119-t1x9gknd 3604 20 concentrations concentration NNS cord-010119-t1x9gknd 3604 21 of of IN cord-010119-t1x9gknd 3604 22 glycerol glycerol NN cord-010119-t1x9gknd 3604 23 in in IN cord-010119-t1x9gknd 3604 24 the the DT cord-010119-t1x9gknd 3604 25 frozen frozen JJ cord-010119-t1x9gknd 3604 26 RCC RCC NNP cord-010119-t1x9gknd 3604 27 product product NN cord-010119-t1x9gknd 3604 28 and and CC cord-010119-t1x9gknd 3604 29 may may MD cord-010119-t1x9gknd 3604 30 lead lead VB cord-010119-t1x9gknd 3604 31 to to IN cord-010119-t1x9gknd 3604 32 differences difference NNS cord-010119-t1x9gknd 3604 33 in in IN cord-010119-t1x9gknd 3604 34 frozen frozen JJ cord-010119-t1x9gknd 3604 35 RCC RCC NNP cord-010119-t1x9gknd 3604 36 quality quality NN cord-010119-t1x9gknd 3604 37 . . . cord-010119-t1x9gknd 3605 1 Additionally additionally RB cord-010119-t1x9gknd 3605 2 , , , cord-010119-t1x9gknd 3605 3 the the DT cord-010119-t1x9gknd 3605 4 size size NN cord-010119-t1x9gknd 3605 5 of of IN cord-010119-t1x9gknd 3605 6 the the DT cord-010119-t1x9gknd 3605 7 RCC RCC NNP cord-010119-t1x9gknd 3605 8 impacts impact VBZ cord-010119-t1x9gknd 3605 9 quality quality NN cord-010119-t1x9gknd 3605 10 for for IN cord-010119-t1x9gknd 3605 11 RCCs rccs NN cord-010119-t1x9gknd 3605 12 processed process VBN cord-010119-t1x9gknd 3605 13 on on IN cord-010119-t1x9gknd 3605 14 the the DT cord-010119-t1x9gknd 3605 15 closed closed JJ cord-010119-t1x9gknd 3605 16 cell cell NN cord-010119-t1x9gknd 3605 17 processor processor NN cord-010119-t1x9gknd 3605 18 due due JJ cord-010119-t1x9gknd 3605 19 to to IN cord-010119-t1x9gknd 3605 20 centrifuge centrifuge NN cord-010119-t1x9gknd 3605 21 bowl bowl NN cord-010119-t1x9gknd 3605 22 volume volume NN cord-010119-t1x9gknd 3605 23 limitations limitation NNS cord-010119-t1x9gknd 3605 24 which which WDT cord-010119-t1x9gknd 3605 25 result result VBP cord-010119-t1x9gknd 3605 26 in in IN cord-010119-t1x9gknd 3605 27 lower low JJR cord-010119-t1x9gknd 3605 28 recovery recovery NN cord-010119-t1x9gknd 3605 29 , , , cord-010119-t1x9gknd 3605 30 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3605 31 , , , cord-010119-t1x9gknd 3605 32 and and CC cord-010119-t1x9gknd 3605 33 hematocrits hematocrit NNS cord-010119-t1x9gknd 3605 34 . . . cord-010119-t1x9gknd 3606 1 Use use NN cord-010119-t1x9gknd 3606 2 of of IN cord-010119-t1x9gknd 3606 3 the the DT cord-010119-t1x9gknd 3606 4 closed closed JJ cord-010119-t1x9gknd 3606 5 cell cell NN cord-010119-t1x9gknd 3606 6 processor processor NN cord-010119-t1x9gknd 3606 7 with with IN cord-010119-t1x9gknd 3606 8 resuspension resuspension NN cord-010119-t1x9gknd 3606 9 in in IN cord-010119-t1x9gknd 3606 10 AS-3 AS-3 NNP cord-010119-t1x9gknd 3606 11 and and CC cord-010119-t1x9gknd 3606 12 storage storage NN cord-010119-t1x9gknd 3606 13 for for IN cord-010119-t1x9gknd 3606 14 24 24 CD cord-010119-t1x9gknd 3606 15 6 6 CD cord-010119-t1x9gknd 3606 16 2 2 CD cord-010119-t1x9gknd 3606 17 h h NN cord-010119-t1x9gknd 3606 18 , , , cord-010119-t1x9gknd 3606 19 met meet VBN cord-010119-t1x9gknd 3606 20 in in IN cord-010119-t1x9gknd 3606 21 vitro vitro FW cord-010119-t1x9gknd 3606 22 quality quality NN cord-010119-t1x9gknd 3606 23 standards standard NNS cord-010119-t1x9gknd 3606 24 for for IN cord-010119-t1x9gknd 3606 25 recovery recovery NN cord-010119-t1x9gknd 3606 26 , , , cord-010119-t1x9gknd 3606 27 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3606 28 , , , cord-010119-t1x9gknd 3606 29 and and CC cord-010119-t1x9gknd 3606 30 hematocrit hematocrit NN cord-010119-t1x9gknd 3606 31 , , , cord-010119-t1x9gknd 3606 32 and and CC cord-010119-t1x9gknd 3606 33 drastically drastically RB cord-010119-t1x9gknd 3606 34 reduced reduce VBN cord-010119-t1x9gknd 3606 35 hemolysis hemolysis NN cord-010119-t1x9gknd 3606 36 levels level NNS cord-010119-t1x9gknd 3606 37 in in IN cord-010119-t1x9gknd 3606 38 RCCs rccs NN cord-010119-t1x9gknd 3606 39 glycerolized glycerolize VBN cord-010119-t1x9gknd 3606 40 manually manually RB cord-010119-t1x9gknd 3606 41 . . . cord-010119-t1x9gknd 3607 1 The the DT cord-010119-t1x9gknd 3607 2 ACP-215 acp-215 NN cord-010119-t1x9gknd 3607 3 cell cell NN cord-010119-t1x9gknd 3607 4 processor processor NN cord-010119-t1x9gknd 3607 5 can can MD cord-010119-t1x9gknd 3607 6 therefore therefore RB cord-010119-t1x9gknd 3607 7 be be VB cord-010119-t1x9gknd 3607 8 used use VBN cord-010119-t1x9gknd 3607 9 to to IN cord-010119-t1x9gknd 3607 10 deglycerolize deglycerolize NNP cord-010119-t1x9gknd 3607 11 RCCs RCCs NNP cord-010119-t1x9gknd 3607 12 glycerolized glycerolize VBN cord-010119-t1x9gknd 3607 13 using use VBG cord-010119-t1x9gknd 3607 14 a a DT cord-010119-t1x9gknd 3607 15 manual manual JJ cord-010119-t1x9gknd 3607 16 , , , cord-010119-t1x9gknd 3607 17 open open JJ cord-010119-t1x9gknd 3607 18 system system NN cord-010119-t1x9gknd 3607 19 glycerolization glycerolization NN cord-010119-t1x9gknd 3607 20 method method NN cord-010119-t1x9gknd 3607 21 . . . cord-010119-t1x9gknd 3608 1 Background Background NNP cord-010119-t1x9gknd 3608 2 / / SYM cord-010119-t1x9gknd 3608 3 Case Case NNP cord-010119-t1x9gknd 3608 4 Studies Studies NNPS cord-010119-t1x9gknd 3608 5 : : : cord-010119-t1x9gknd 3609 1 Washed washed JJ cord-010119-t1x9gknd 3609 2 platelets platelet NNS cord-010119-t1x9gknd 3609 3 may may MD cord-010119-t1x9gknd 3609 4 be be VB cord-010119-t1x9gknd 3609 5 indicated indicate VBN cord-010119-t1x9gknd 3609 6 for for IN cord-010119-t1x9gknd 3609 7 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 3609 8 patients patient NNS cord-010119-t1x9gknd 3609 9 who who WP cord-010119-t1x9gknd 3609 10 experience experience VBP cord-010119-t1x9gknd 3609 11 severe severe JJ cord-010119-t1x9gknd 3609 12 allergic allergic JJ cord-010119-t1x9gknd 3609 13 / / SYM cord-010119-t1x9gknd 3609 14 anaphylactic anaphylactic JJ cord-010119-t1x9gknd 3609 15 or or CC cord-010119-t1x9gknd 3609 16 febrile febrile JJ cord-010119-t1x9gknd 3609 17 reactions reaction NNS cord-010119-t1x9gknd 3609 18 to to IN cord-010119-t1x9gknd 3609 19 conventional conventional JJ cord-010119-t1x9gknd 3609 20 platelet platelet NN cord-010119-t1x9gknd 3609 21 transfusions transfusion NNS cord-010119-t1x9gknd 3609 22 . . . cord-010119-t1x9gknd 3610 1 Platelet platelet NN cord-010119-t1x9gknd 3610 2 washing washing NN cord-010119-t1x9gknd 3610 3 process process NN cord-010119-t1x9gknd 3610 4 is be VBZ cord-010119-t1x9gknd 3610 5 time time NN cord-010119-t1x9gknd 3610 6 - - HYPH cord-010119-t1x9gknd 3610 7 consuming consume VBG cord-010119-t1x9gknd 3610 8 which which WDT cord-010119-t1x9gknd 3610 9 may may MD cord-010119-t1x9gknd 3610 10 delay delay VB cord-010119-t1x9gknd 3610 11 transfusion transfusion NN cord-010119-t1x9gknd 3610 12 . . . cord-010119-t1x9gknd 3611 1 This this DT cord-010119-t1x9gknd 3611 2 study study NN cord-010119-t1x9gknd 3611 3 was be VBD cord-010119-t1x9gknd 3611 4 conducted conduct VBN cord-010119-t1x9gknd 3611 5 to to TO cord-010119-t1x9gknd 3611 6 evaluate evaluate VB cord-010119-t1x9gknd 3611 7 the the DT cord-010119-t1x9gknd 3611 8 manual manual JJ cord-010119-t1x9gknd 3611 9 platelet platelet NN cord-010119-t1x9gknd 3611 10 washing washing NN cord-010119-t1x9gknd 3611 11 method method NN cord-010119-t1x9gknd 3611 12 ( ( -LRB- cord-010119-t1x9gknd 3611 13 MM MM NNP cord-010119-t1x9gknd 3611 14 ) ) -RRB- cord-010119-t1x9gknd 3611 15 using use VBG cord-010119-t1x9gknd 3611 16 0.9 0.9 CD cord-010119-t1x9gknd 3611 17 % % NN cord-010119-t1x9gknd 3611 18 saline saline NN cord-010119-t1x9gknd 3611 19 and and CC cord-010119-t1x9gknd 3611 20 centrifugation centrifugation NN cord-010119-t1x9gknd 3611 21 and and CC cord-010119-t1x9gknd 3611 22 the the DT cord-010119-t1x9gknd 3611 23 semi semi RB cord-010119-t1x9gknd 3611 24 - - JJ cord-010119-t1x9gknd 3611 25 automated automated JJ cord-010119-t1x9gknd 3611 26 washing washing NN cord-010119-t1x9gknd 3611 27 method method NN cord-010119-t1x9gknd 3611 28 ( ( -LRB- cord-010119-t1x9gknd 3611 29 SAM SAM NNP cord-010119-t1x9gknd 3611 30 ) ) -RRB- cord-010119-t1x9gknd 3611 31 using use VBG cord-010119-t1x9gknd 3611 32 the the DT cord-010119-t1x9gknd 3611 33 COBE COBE NNP cord-010119-t1x9gknd 3611 34 2991Blood 2991blood CD cord-010119-t1x9gknd 3611 35 Cell Cell NNP cord-010119-t1x9gknd 3611 36 Processor Processor NNP cord-010119-t1x9gknd 3611 37 . . . cord-010119-t1x9gknd 3612 1 Study Study NNP cord-010119-t1x9gknd 3612 2 Design Design NNP cord-010119-t1x9gknd 3612 3 / / SYM cord-010119-t1x9gknd 3612 4 Method method NN cord-010119-t1x9gknd 3612 5 : : : cord-010119-t1x9gknd 3613 1 In in IN cord-010119-t1x9gknd 3613 2 this this DT cord-010119-t1x9gknd 3613 3 study study NN cord-010119-t1x9gknd 3613 4 , , , cord-010119-t1x9gknd 3613 5 20 20 CD cord-010119-t1x9gknd 3613 6 units unit NNS cord-010119-t1x9gknd 3613 7 of of IN cord-010119-t1x9gknd 3613 8 single single JJ cord-010119-t1x9gknd 3613 9 donor donor NN cord-010119-t1x9gknd 3613 10 platelets platelet NNS cord-010119-t1x9gknd 3613 11 were be VBD cord-010119-t1x9gknd 3613 12 evaluated evaluate VBN cord-010119-t1x9gknd 3613 13 ( ( -LRB- cord-010119-t1x9gknd 3613 14 10 10 CD cord-010119-t1x9gknd 3613 15 washed wash VBN cord-010119-t1x9gknd 3613 16 using use VBG cord-010119-t1x9gknd 3613 17 the the DT cord-010119-t1x9gknd 3613 18 MM MM NNP cord-010119-t1x9gknd 3613 19 and and CC cord-010119-t1x9gknd 3613 20 10 10 CD cord-010119-t1x9gknd 3613 21 washed wash VBD cord-010119-t1x9gknd 3613 22 using use VBG cord-010119-t1x9gknd 3613 23 the the DT cord-010119-t1x9gknd 3613 24 SAM SAM NNP cord-010119-t1x9gknd 3613 25 . . . cord-010119-t1x9gknd 3614 1 The the DT cord-010119-t1x9gknd 3614 2 collected collect VBN cord-010119-t1x9gknd 3614 3 data datum NNS cord-010119-t1x9gknd 3614 4 included include VBD cord-010119-t1x9gknd 3614 5 product product NN cord-010119-t1x9gknd 3614 6 weights weight NNS cord-010119-t1x9gknd 3614 7 ( ( -LRB- cord-010119-t1x9gknd 3614 8 pre pre VB cord-010119-t1x9gknd 3614 9 - - JJ cord-010119-t1x9gknd 3614 10 and and CC cord-010119-t1x9gknd 3614 11 post post JJ cord-010119-t1x9gknd 3614 12 - - JJ cord-010119-t1x9gknd 3614 13 wash wash JJ cord-010119-t1x9gknd 3614 14 ) ) -RRB- cord-010119-t1x9gknd 3614 15 , , , cord-010119-t1x9gknd 3614 16 platelet platelet NN cord-010119-t1x9gknd 3614 17 counts count NNS cord-010119-t1x9gknd 3614 18 ( ( -LRB- cord-010119-t1x9gknd 3614 19 pre pre VB cord-010119-t1x9gknd 3614 20 - - JJ cord-010119-t1x9gknd 3614 21 and and CC cord-010119-t1x9gknd 3614 22 post post JJ cord-010119-t1x9gknd 3614 23 - - JJ cord-010119-t1x9gknd 3614 24 wash wash JJ cord-010119-t1x9gknd 3614 25 ) ) -RRB- cord-010119-t1x9gknd 3614 26 , , , cord-010119-t1x9gknd 3614 27 total total JJ cord-010119-t1x9gknd 3614 28 plasma plasma NN cord-010119-t1x9gknd 3614 29 protein protein NN cord-010119-t1x9gknd 3614 30 ( ( -LRB- cord-010119-t1x9gknd 3614 31 pre pre VB cord-010119-t1x9gknd 3614 32 - - JJ cord-010119-t1x9gknd 3614 33 and and CC cord-010119-t1x9gknd 3614 34 post post JJ cord-010119-t1x9gknd 3614 35 - - JJ cord-010119-t1x9gknd 3614 36 wash wash JJ cord-010119-t1x9gknd 3614 37 ) ) -RRB- cord-010119-t1x9gknd 3614 38 , , , cord-010119-t1x9gknd 3614 39 presence presence NN cord-010119-t1x9gknd 3614 40 / / SYM cord-010119-t1x9gknd 3614 41 absence absence NN cord-010119-t1x9gknd 3614 42 of of IN cord-010119-t1x9gknd 3614 43 platelet platelet NN cord-010119-t1x9gknd 3614 44 clumps clump NNS cord-010119-t1x9gknd 3614 45 , , , cord-010119-t1x9gknd 3614 46 calculated calculate VBN cord-010119-t1x9gknd 3614 47 % % NN cord-010119-t1x9gknd 3614 48 protein protein NN cord-010119-t1x9gknd 3614 49 removal removal NN cord-010119-t1x9gknd 3614 50 , , , cord-010119-t1x9gknd 3614 51 and and CC cord-010119-t1x9gknd 3614 52 calculated calculate VBN cord-010119-t1x9gknd 3614 53 % % NN cord-010119-t1x9gknd 3614 54 platelet platelet NN cord-010119-t1x9gknd 3614 55 recovery recovery NN cord-010119-t1x9gknd 3614 56 rate rate NN cord-010119-t1x9gknd 3614 57 . . . cord-010119-t1x9gknd 3615 1 The the DT cord-010119-t1x9gknd 3615 2 platelet platelet NN cord-010119-t1x9gknd 3615 3 counts count NNS cord-010119-t1x9gknd 3615 4 were be VBD cord-010119-t1x9gknd 3615 5 measured measure VBN cord-010119-t1x9gknd 3615 6 on on IN cord-010119-t1x9gknd 3615 7 the the DT cord-010119-t1x9gknd 3615 8 Sysmex Sysmex NNP cord-010119-t1x9gknd 3615 9 EXN EXN NNP cord-010119-t1x9gknd 3615 10 and and CC cord-010119-t1x9gknd 3615 11 the the DT cord-010119-t1x9gknd 3615 12 total total JJ cord-010119-t1x9gknd 3615 13 plasma plasma NN cord-010119-t1x9gknd 3615 14 protein protein NN cord-010119-t1x9gknd 3615 15 samples sample NNS cord-010119-t1x9gknd 3615 16 were be VBD cord-010119-t1x9gknd 3615 17 measured measure VBN cord-010119-t1x9gknd 3615 18 on on IN cord-010119-t1x9gknd 3615 19 the the DT cord-010119-t1x9gknd 3615 20 Roche Roche NNP cord-010119-t1x9gknd 3615 21 Cobas Cobas NNP cord-010119-t1x9gknd 3615 22 6000 6000 CD cord-010119-t1x9gknd 3615 23 . . . cord-010119-t1x9gknd 3616 1 Results/ Results/ . cord-010119-t1x9gknd 3617 1 Finding finding NN cord-010119-t1x9gknd 3617 2 : : : cord-010119-t1x9gknd 3618 1 Table table NN cord-010119-t1x9gknd 3618 2 1 1 CD cord-010119-t1x9gknd 3618 3 shows show VBZ cord-010119-t1x9gknd 3618 4 that that IN cord-010119-t1x9gknd 3618 5 the the DT cord-010119-t1x9gknd 3618 6 average average JJ cord-010119-t1x9gknd 3618 7 platelet platelet NN cord-010119-t1x9gknd 3618 8 recovery recovery NN cord-010119-t1x9gknd 3618 9 for for IN cord-010119-t1x9gknd 3618 10 the the DT cord-010119-t1x9gknd 3618 11 SAM SAM NNP cord-010119-t1x9gknd 3618 12 ( ( -LRB- cord-010119-t1x9gknd 3618 13 92 92 CD cord-010119-t1x9gknd 3618 14 % % NN cord-010119-t1x9gknd 3618 15 ) ) -RRB- cord-010119-t1x9gknd 3618 16 was be VBD cord-010119-t1x9gknd 3618 17 significantly significantly RB cord-010119-t1x9gknd 3618 18 higher high JJR cord-010119-t1x9gknd 3618 19 compared compare VBN cord-010119-t1x9gknd 3618 20 to to IN cord-010119-t1x9gknd 3618 21 the the DT cord-010119-t1x9gknd 3618 22 MM MM NNP cord-010119-t1x9gknd 3618 23 ( ( -LRB- cord-010119-t1x9gknd 3618 24 82 82 CD cord-010119-t1x9gknd 3618 25 % % NN cord-010119-t1x9gknd 3618 26 ) ) -RRB- cord-010119-t1x9gknd 3618 27 . . . cord-010119-t1x9gknd 3619 1 The the DT cord-010119-t1x9gknd 3619 2 MM MM NNP cord-010119-t1x9gknd 3619 3 had have VBD cord-010119-t1x9gknd 3619 4 a a DT cord-010119-t1x9gknd 3619 5 slightly slightly RB cord-010119-t1x9gknd 3619 6 higher high JJR cord-010119-t1x9gknd 3619 7 average average JJ cord-010119-t1x9gknd 3619 8 protein protein NN cord-010119-t1x9gknd 3619 9 removal removal NN cord-010119-t1x9gknd 3619 10 compared compare VBN cord-010119-t1x9gknd 3619 11 to to IN cord-010119-t1x9gknd 3619 12 the the DT cord-010119-t1x9gknd 3619 13 SAM SAM NNP cord-010119-t1x9gknd 3619 14 . . . cord-010119-t1x9gknd 3620 1 No no DT cord-010119-t1x9gknd 3620 2 platelet platelet NN cord-010119-t1x9gknd 3620 3 clumps clump NNS cord-010119-t1x9gknd 3620 4 were be VBD cord-010119-t1x9gknd 3620 5 observed observe VBN cord-010119-t1x9gknd 3620 6 in in IN cord-010119-t1x9gknd 3620 7 either either CC cord-010119-t1x9gknd 3620 8 the the DT cord-010119-t1x9gknd 3620 9 MM MM NNP cord-010119-t1x9gknd 3620 10 or or CC cord-010119-t1x9gknd 3620 11 the the DT cord-010119-t1x9gknd 3620 12 SAM SAM NNP cord-010119-t1x9gknd 3620 13 . . . cord-010119-t1x9gknd 3621 1 It -PRON- PRP cord-010119-t1x9gknd 3621 2 was be VBD cord-010119-t1x9gknd 3621 3 observed observe VBN cord-010119-t1x9gknd 3621 4 that that IN cord-010119-t1x9gknd 3621 5 the the DT cord-010119-t1x9gknd 3621 6 hands hand NNS cord-010119-t1x9gknd 3621 7 - - HYPH cord-010119-t1x9gknd 3621 8 on on RP cord-010119-t1x9gknd 3621 9 time time NN cord-010119-t1x9gknd 3621 10 for for IN cord-010119-t1x9gknd 3621 11 the the DT cord-010119-t1x9gknd 3621 12 MM MM NNP cord-010119-t1x9gknd 3621 13 took take VBD cord-010119-t1x9gknd 3621 14 10 10 CD cord-010119-t1x9gknd 3621 15 - - SYM cord-010119-t1x9gknd 3621 16 15 15 CD cord-010119-t1x9gknd 3621 17 minutes minute NNS cord-010119-t1x9gknd 3621 18 longer long RBR cord-010119-t1x9gknd 3621 19 than than IN cord-010119-t1x9gknd 3621 20 the the DT cord-010119-t1x9gknd 3621 21 SAM SAM NNP cord-010119-t1x9gknd 3621 22 . . . cord-010119-t1x9gknd 3621 23 _SP cord-010119-t1x9gknd 3622 1 Background Background NNP cord-010119-t1x9gknd 3622 2 / / SYM cord-010119-t1x9gknd 3622 3 Case Case NNP cord-010119-t1x9gknd 3622 4 Studies Studies NNPS cord-010119-t1x9gknd 3622 5 : : : cord-010119-t1x9gknd 3623 1 The the DT cord-010119-t1x9gknd 3623 2 INTERCEPTV INTERCEPTV NNP cord-010119-t1x9gknd 3623 3 R r NN cord-010119-t1x9gknd 3623 4 Blood blood NN cord-010119-t1x9gknd 3623 5 System system NN cord-010119-t1x9gknd 3623 6 for for IN cord-010119-t1x9gknd 3623 7 platelets platelet NNS cord-010119-t1x9gknd 3623 8 is be VBZ cord-010119-t1x9gknd 3623 9 currently currently RB cord-010119-t1x9gknd 3623 10 licensed license VBN cord-010119-t1x9gknd 3623 11 for for IN cord-010119-t1x9gknd 3623 12 pathogen pathogen NN cord-010119-t1x9gknd 3623 13 reduction reduction NN cord-010119-t1x9gknd 3623 14 ( ( -LRB- cord-010119-t1x9gknd 3623 15 PR PR NNP cord-010119-t1x9gknd 3623 16 ) ) -RRB- cord-010119-t1x9gknd 3623 17 of of IN cord-010119-t1x9gknd 3623 18 Amicus Amicus NNP cord-010119-t1x9gknd 3623 19 platelets platelet NNS cord-010119-t1x9gknd 3623 20 in in IN cord-010119-t1x9gknd 3623 21 Inter Inter NNP cord-010119-t1x9gknd 3623 22 - - HYPH cord-010119-t1x9gknd 3623 23 Sol Sol NNP cord-010119-t1x9gknd 3623 24 ( ( -LRB- cord-010119-t1x9gknd 3623 25 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 3623 26 ) ) -RRB- cord-010119-t1x9gknd 3623 27 for for IN cord-010119-t1x9gknd 3623 28 input input JJ cord-010119-t1x9gknd 3623 29 platelet platelet NN cord-010119-t1x9gknd 3623 30 doses dose NNS cord-010119-t1x9gknd 3623 31 of of IN cord-010119-t1x9gknd 3623 32 2.9 2.9 CD cord-010119-t1x9gknd 3623 33 to to TO cord-010119-t1x9gknd 3623 34 8.0 8.0 CD cord-010119-t1x9gknd 3623 35 3 3 CD cord-010119-t1x9gknd 3623 36 10 10 CD cord-010119-t1x9gknd 3623 37 11 11 CD cord-010119-t1x9gknd 3623 38 platelets platelet NNS cord-010119-t1x9gknd 3623 39 in in IN cord-010119-t1x9gknd 3623 40 255 255 CD cord-010119-t1x9gknd 3623 41 to to IN cord-010119-t1x9gknd 3623 42 420 420 CD cord-010119-t1x9gknd 3623 43 mL ml NN cord-010119-t1x9gknd 3623 44 of of IN cord-010119-t1x9gknd 3623 45 47 47 CD cord-010119-t1x9gknd 3623 46 to to TO cord-010119-t1x9gknd 3623 47 68 68 CD cord-010119-t1x9gknd 3623 48 % % NN cord-010119-t1x9gknd 3623 49 plasma plasma NN cord-010119-t1x9gknd 3623 50 and and CC cord-010119-t1x9gknd 3623 51 32 32 CD cord-010119-t1x9gknd 3623 52 - - SYM cord-010119-t1x9gknd 3623 53 53 53 CD cord-010119-t1x9gknd 3623 54 % % NN cord-010119-t1x9gknd 3623 55 PAS pas NN cord-010119-t1x9gknd 3623 56 . . . cord-010119-t1x9gknd 3624 1 A a DT cord-010119-t1x9gknd 3624 2 new new JJ cord-010119-t1x9gknd 3624 3 platelet platelet NN cord-010119-t1x9gknd 3624 4 processing processing NN cord-010119-t1x9gknd 3624 5 set set NN cord-010119-t1x9gknd 3624 6 was be VBD cord-010119-t1x9gknd 3624 7 designed design VBN cord-010119-t1x9gknd 3624 8 with with IN cord-010119-t1x9gknd 3624 9 three three CD cord-010119-t1x9gknd 3624 10 storage storage NN cord-010119-t1x9gknd 3624 11 containers container NNS cord-010119-t1x9gknd 3624 12 ( ( -LRB- cord-010119-t1x9gknd 3624 13 TS TS NNP cord-010119-t1x9gknd 3624 14 ) ) -RRB- cord-010119-t1x9gknd 3624 15 to to TO cord-010119-t1x9gknd 3624 16 process process VB cord-010119-t1x9gknd 3624 17 apheresis apheresis NN cord-010119-t1x9gknd 3624 18 platelet platelet NN cord-010119-t1x9gknd 3624 19 components component NNS cord-010119-t1x9gknd 3624 20 in in IN cord-010119-t1x9gknd 3624 21 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 3624 22 containing contain VBG cord-010119-t1x9gknd 3624 23 doses dose NNS cord-010119-t1x9gknd 3624 24 of of IN cord-010119-t1x9gknd 3624 25 6.0 6.0 CD cord-010119-t1x9gknd 3624 26 to to IN cord-010119-t1x9gknd 3624 27 12.0 12.0 CD cord-010119-t1x9gknd 3624 28 3 3 CD cord-010119-t1x9gknd 3625 1 10 10 CD cord-010119-t1x9gknd 3625 2 11 11 CD cord-010119-t1x9gknd 3625 3 platelets platelet NNS cord-010119-t1x9gknd 3625 4 in in IN cord-010119-t1x9gknd 3625 5 a a DT cord-010119-t1x9gknd 3625 6 volume volume NN cord-010119-t1x9gknd 3625 7 of of IN cord-010119-t1x9gknd 3625 8 420 420 CD cord-010119-t1x9gknd 3625 9 to to TO cord-010119-t1x9gknd 3625 10 650 650 CD cord-010119-t1x9gknd 3625 11 mL. mL. NNPS cord-010119-t1x9gknd 3625 12 Study Study NNP cord-010119-t1x9gknd 3625 13 Design Design NNP cord-010119-t1x9gknd 3625 14 / / SYM cord-010119-t1x9gknd 3625 15 Methods method NNS cord-010119-t1x9gknd 3625 16 : : : cord-010119-t1x9gknd 3626 1 Apheresis apheresis NN cord-010119-t1x9gknd 3626 2 PCs pc NNS cord-010119-t1x9gknd 3626 3 ( ( -LRB- cord-010119-t1x9gknd 3626 4 Amicus amicus NN cord-010119-t1x9gknd 3626 5 V V NNP cord-010119-t1x9gknd 3626 6 R r NN cord-010119-t1x9gknd 3626 7 ) ) -RRB- cord-010119-t1x9gknd 3626 8 were be VBD cord-010119-t1x9gknd 3626 9 collected collect VBN cord-010119-t1x9gknd 3626 10 in in IN cord-010119-t1x9gknd 3626 11 35 35 CD cord-010119-t1x9gknd 3626 12 % % NN cord-010119-t1x9gknd 3626 13 plasma plasma NN cord-010119-t1x9gknd 3626 14 and and CC cord-010119-t1x9gknd 3626 15 65 65 CD cord-010119-t1x9gknd 3626 16 % % NN cord-010119-t1x9gknd 3626 17 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 3626 18 . . . cord-010119-t1x9gknd 3627 1 One one CD cord-010119-t1x9gknd 3627 2 study study NN cord-010119-t1x9gknd 3627 3 was be VBD cord-010119-t1x9gknd 3627 4 performed perform VBN cord-010119-t1x9gknd 3627 5 at at IN cord-010119-t1x9gknd 3627 6 the the DT cord-010119-t1x9gknd 3627 7 nominal nominal JJ cord-010119-t1x9gknd 3627 8 dose dose NN cord-010119-t1x9gknd 3627 9 ( ( -LRB- cord-010119-t1x9gknd 3627 10 9.2 9.2 CD cord-010119-t1x9gknd 3627 11 -10.0 -10.0 SYM cord-010119-t1x9gknd 3627 12 x10 x10 CD cord-010119-t1x9gknd 3627 13 11 11 CD cord-010119-t1x9gknd 3627 14 platelets platelet NNS cord-010119-t1x9gknd 3627 15 ) ) -RRB- cord-010119-t1x9gknd 3627 16 , , , cord-010119-t1x9gknd 3627 17 volume volume NN cord-010119-t1x9gknd 3627 18 ( ( -LRB- cord-010119-t1x9gknd 3627 19 558 558 CD cord-010119-t1x9gknd 3627 20 -629 -629 NN cord-010119-t1x9gknd 3627 21 mL mL NNP cord-010119-t1x9gknd 3627 22 ) ) -RRB- cord-010119-t1x9gknd 3627 23 in in IN cord-010119-t1x9gknd 3627 24 65 65 CD cord-010119-t1x9gknd 3627 25 % % NN cord-010119-t1x9gknd 3627 26 PAS/35 pas/35 JJ cord-010119-t1x9gknd 3627 27 % % NN cord-010119-t1x9gknd 3627 28 plasma plasma NN cord-010119-t1x9gknd 3627 29 using use VBG cord-010119-t1x9gknd 3627 30 single single JJ cord-010119-t1x9gknd 3627 31 donor donor NN cord-010119-t1x9gknd 3627 32 apheresis apheresis NN cord-010119-t1x9gknd 3627 33 collections collection NNS cord-010119-t1x9gknd 3627 34 . . . cord-010119-t1x9gknd 3628 1 Two two CD cord-010119-t1x9gknd 3628 2 studies study NNS cord-010119-t1x9gknd 3628 3 were be VBD cord-010119-t1x9gknd 3628 4 performed perform VBN cord-010119-t1x9gknd 3628 5 to to TO cord-010119-t1x9gknd 3628 6 evaluate evaluate VB cord-010119-t1x9gknd 3628 7 the the DT cord-010119-t1x9gknd 3628 8 high high JJ cord-010119-t1x9gknd 3628 9 dose dose NN cord-010119-t1x9gknd 3628 10 and and CC cord-010119-t1x9gknd 3628 11 high high JJ cord-010119-t1x9gknd 3628 12 volume volume NN cord-010119-t1x9gknd 3628 13 condition condition NN cord-010119-t1x9gknd 3628 14 ( ( -LRB- cord-010119-t1x9gknd 3628 15 9.7 9.7 CD cord-010119-t1x9gknd 3628 16 -11.8 -11.8 CD cord-010119-t1x9gknd 3628 17 x x SYM cord-010119-t1x9gknd 3628 18 10 10 CD cord-010119-t1x9gknd 3628 19 11 11 CD cord-010119-t1x9gknd 3628 20 platelets platelet NNS cord-010119-t1x9gknd 3628 21 in in IN cord-010119-t1x9gknd 3628 22 593 593 CD cord-010119-t1x9gknd 3628 23 -659 -659 NNS cord-010119-t1x9gknd 3628 24 mL ml NN cord-010119-t1x9gknd 3628 25 ) ) -RRB- cord-010119-t1x9gknd 3628 26 using use VBG cord-010119-t1x9gknd 3628 27 either either CC cord-010119-t1x9gknd 3628 28 single single JJ cord-010119-t1x9gknd 3628 29 or or CC cord-010119-t1x9gknd 3628 30 pooled pool VBN cord-010119-t1x9gknd 3628 31 donations donation NNS cord-010119-t1x9gknd 3628 32 . . . cord-010119-t1x9gknd 3629 1 Input input NN cord-010119-t1x9gknd 3629 2 PCs pc NNS cord-010119-t1x9gknd 3629 3 ( ( -LRB- cord-010119-t1x9gknd 3629 4 n520 n520 NNS cord-010119-t1x9gknd 3629 5 ) ) -RRB- cord-010119-t1x9gknd 3629 6 were be VBD cord-010119-t1x9gknd 3629 7 treated treat VBN cord-010119-t1x9gknd 3629 8 with with IN cord-010119-t1x9gknd 3629 9 the the DT cord-010119-t1x9gknd 3629 10 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 3629 11 TS TS NNP cord-010119-t1x9gknd 3629 12 set set VBN cord-010119-t1x9gknd 3629 13 by by IN cord-010119-t1x9gknd 3629 14 the the DT cord-010119-t1x9gknd 3629 15 end end NN cord-010119-t1x9gknd 3629 16 of of IN cord-010119-t1x9gknd 3629 17 Day day NN cord-010119-t1x9gknd 3629 18 1 1 CD cord-010119-t1x9gknd 3629 19 post post NN cord-010119-t1x9gknd 3629 20 collection collection NN cord-010119-t1x9gknd 3629 21 ; ; : cord-010119-t1x9gknd 3629 22 the the DT cord-010119-t1x9gknd 3629 23 incubation incubation NN cord-010119-t1x9gknd 3629 24 time time NN cord-010119-t1x9gknd 3629 25 in in IN cord-010119-t1x9gknd 3629 26 the the DT cord-010119-t1x9gknd 3629 27 Compound Compound NNP cord-010119-t1x9gknd 3629 28 Adsorption Adsorption NNP cord-010119-t1x9gknd 3629 29 Device Device NNP cord-010119-t1x9gknd 3629 30 ( ( -LRB- cord-010119-t1x9gknd 3629 31 CAD CAD NNP cord-010119-t1x9gknd 3629 32 ) ) -RRB- cord-010119-t1x9gknd 3629 33 container container NN cord-010119-t1x9gknd 3629 34 ranged range VBD cord-010119-t1x9gknd 3629 35 from from IN cord-010119-t1x9gknd 3629 36 4 4 CD cord-010119-t1x9gknd 3629 37 to to TO cord-010119-t1x9gknd 3629 38 16 16 CD cord-010119-t1x9gknd 3629 39 hours hour NNS cord-010119-t1x9gknd 3629 40 and and CC cord-010119-t1x9gknd 3629 41 the the DT cord-010119-t1x9gknd 3629 42 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 3629 43 treated treat VBN cord-010119-t1x9gknd 3629 44 PCs pc NNS cord-010119-t1x9gknd 3629 45 were be VBD cord-010119-t1x9gknd 3629 46 stored store VBN cord-010119-t1x9gknd 3629 47 in in IN cord-010119-t1x9gknd 3629 48 3 3 CD cord-010119-t1x9gknd 3629 49 containers container NNS cord-010119-t1x9gknd 3629 50 ( ( -LRB- cord-010119-t1x9gknd 3629 51 n560 n560 NNP cord-010119-t1x9gknd 3629 52 ) ) -RRB- cord-010119-t1x9gknd 3629 53 . . . cord-010119-t1x9gknd 3630 1 Day day NN cord-010119-t1x9gknd 3630 2 5 5 CD cord-010119-t1x9gknd 3630 3 and and CC cord-010119-t1x9gknd 3630 4 7 7 CD cord-010119-t1x9gknd 3630 5 post post JJ cord-010119-t1x9gknd 3630 6 - - JJ cord-010119-t1x9gknd 3630 7 donation donation NN cord-010119-t1x9gknd 3630 8 PCs pc NNS cord-010119-t1x9gknd 3630 9 were be VBD cord-010119-t1x9gknd 3630 10 evaluated evaluate VBN cord-010119-t1x9gknd 3630 11 using use VBG cord-010119-t1x9gknd 3630 12 a a DT cord-010119-t1x9gknd 3630 13 panel panel NN cord-010119-t1x9gknd 3630 14 of of IN cord-010119-t1x9gknd 3630 15 in in FW cord-010119-t1x9gknd 3630 16 vitro vitro FW cord-010119-t1x9gknd 3630 17 platelet platelet NN cord-010119-t1x9gknd 3630 18 function function NN cord-010119-t1x9gknd 3631 1 assays assay NNS cord-010119-t1x9gknd 3631 2 Results result NNS cord-010119-t1x9gknd 3631 3 / / SYM cord-010119-t1x9gknd 3631 4 Findings finding NNS cord-010119-t1x9gknd 3631 5 : : : cord-010119-t1x9gknd 3632 1 In in IN cord-010119-t1x9gknd 3632 2 vitro vitro FW cord-010119-t1x9gknd 3632 3 function function NN cord-010119-t1x9gknd 3632 4 data datum NNS cord-010119-t1x9gknd 3632 5 for for IN cord-010119-t1x9gknd 3632 6 apheresis apheresis NN cord-010119-t1x9gknd 3632 7 PCs pc NNS cord-010119-t1x9gknd 3632 8 in in IN cord-010119-t1x9gknd 3632 9 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 3632 10 treated treat VBN cord-010119-t1x9gknd 3632 11 in in IN cord-010119-t1x9gknd 3632 12 the the DT cord-010119-t1x9gknd 3632 13 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 3632 14 TS TS NNP cord-010119-t1x9gknd 3632 15 set set NN cord-010119-t1x9gknd 3632 16 demonstrated demonstrate VBN cord-010119-t1x9gknd 3632 17 acceptable acceptable JJ cord-010119-t1x9gknd 3632 18 in in IN cord-010119-t1x9gknd 3632 19 vitro vitro FW cord-010119-t1x9gknd 3632 20 function function NN cord-010119-t1x9gknd 3633 1 ( ( -LRB- cord-010119-t1x9gknd 3633 2 Table table NN cord-010119-t1x9gknd 3633 3 _SP cord-010119-t1x9gknd 3633 4 1 1 CD cord-010119-t1x9gknd 3633 5 ) ) -RRB- cord-010119-t1x9gknd 3633 6 . . . cord-010119-t1x9gknd 3634 1 All all DT cord-010119-t1x9gknd 3634 2 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 3634 3 treated treat VBN cord-010119-t1x9gknd 3634 4 PCs pc NNS cord-010119-t1x9gknd 3634 5 had have VBD cord-010119-t1x9gknd 3634 6 pH(228C pH(228C NNP cord-010119-t1x9gknd 3634 7 ) ) -RRB- cord-010119-t1x9gknd 3634 8 ! ! . cord-010119-t1x9gknd 3635 1 6.2 6.2 CD cord-010119-t1x9gknd 3635 2 . . . cord-010119-t1x9gknd 3636 1 Platelet platelet NN cord-010119-t1x9gknd 3636 2 dose dose NN cord-010119-t1x9gknd 3636 3 and and CC cord-010119-t1x9gknd 3636 4 volume volume NN cord-010119-t1x9gknd 3636 5 recovery recovery NN cord-010119-t1x9gknd 3636 6 post post NN cord-010119-t1x9gknd 3636 7 - - NN cord-010119-t1x9gknd 3636 8 treatment treatment NN cord-010119-t1x9gknd 3636 9 ranged range VBD cord-010119-t1x9gknd 3636 10 from from IN cord-010119-t1x9gknd 3636 11 82 82 CD cord-010119-t1x9gknd 3636 12 % % NN cord-010119-t1x9gknd 3636 13 to to IN cord-010119-t1x9gknd 3636 14 99 99 CD cord-010119-t1x9gknd 3636 15 % % NN cord-010119-t1x9gknd 3636 16 and and CC cord-010119-t1x9gknd 3636 17 88 88 CD cord-010119-t1x9gknd 3636 18 % % NN cord-010119-t1x9gknd 3636 19 to to IN cord-010119-t1x9gknd 3636 20 92 92 CD cord-010119-t1x9gknd 3636 21 % % NN cord-010119-t1x9gknd 3636 22 , , , cord-010119-t1x9gknd 3636 23 respectively respectively RB cord-010119-t1x9gknd 3636 24 . . . cord-010119-t1x9gknd 3637 1 Conclusion conclusion NN cord-010119-t1x9gknd 3637 2 : : : cord-010119-t1x9gknd 3638 1 Pathogen pathogen NN cord-010119-t1x9gknd 3638 2 reduced reduce VBN cord-010119-t1x9gknd 3638 3 platelet platelet NN cord-010119-t1x9gknd 3638 4 components component NNS cord-010119-t1x9gknd 3638 5 processed process VBN cord-010119-t1x9gknd 3638 6 using use VBG cord-010119-t1x9gknd 3638 7 the the DT cord-010119-t1x9gknd 3638 8 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 3638 9 TS TS NNP cord-010119-t1x9gknd 3638 10 set set VBN cord-010119-t1x9gknd 3638 11 from from IN cord-010119-t1x9gknd 3638 12 either either DT cord-010119-t1x9gknd 3638 13 single single JJ cord-010119-t1x9gknd 3638 14 or or CC cord-010119-t1x9gknd 3638 15 pooled pooled JJ cord-010119-t1x9gknd 3638 16 apheresis apheresis NN cord-010119-t1x9gknd 3638 17 donations donation NNS cord-010119-t1x9gknd 3638 18 maintained maintain VBD cord-010119-t1x9gknd 3638 19 acceptable acceptable JJ cord-010119-t1x9gknd 3638 20 in in IN cord-010119-t1x9gknd 3638 21 vitro vitro FW cord-010119-t1x9gknd 3638 22 quality quality NN cord-010119-t1x9gknd 3638 23 through through IN cord-010119-t1x9gknd 3638 24 7 7 CD cord-010119-t1x9gknd 3638 25 days day NNS cord-010119-t1x9gknd 3638 26 of of IN cord-010119-t1x9gknd 3638 27 storage storage NN cord-010119-t1x9gknd 3638 28 . . . cord-010119-t1x9gknd 3639 1 INTERCEPT intercept VB cord-010119-t1x9gknd 3639 2 Blood blood NN cord-010119-t1x9gknd 3639 3 System system NN cord-010119-t1x9gknd 3639 4 for for IN cord-010119-t1x9gknd 3639 5 Platelets platelet NNS cord-010119-t1x9gknd 3639 6 TS TS NNP cord-010119-t1x9gknd 3639 7 set set NN cord-010119-t1x9gknd 3639 8 is be VBZ cord-010119-t1x9gknd 3639 9 currently currently RB cord-010119-t1x9gknd 3639 10 not not RB cord-010119-t1x9gknd 3639 11 approved approve VBN cord-010119-t1x9gknd 3639 12 for for IN cord-010119-t1x9gknd 3639 13 use use NN cord-010119-t1x9gknd 3639 14 in in IN cord-010119-t1x9gknd 3639 15 the the DT cord-010119-t1x9gknd 3639 16 US US NNP cord-010119-t1x9gknd 3639 17 . . . cord-010119-t1x9gknd 3640 1 Background Background NNP cord-010119-t1x9gknd 3640 2 / / SYM cord-010119-t1x9gknd 3640 3 Case Case NNP cord-010119-t1x9gknd 3640 4 Studies Studies NNPS cord-010119-t1x9gknd 3640 5 : : : cord-010119-t1x9gknd 3641 1 The the DT cord-010119-t1x9gknd 3641 2 possibility possibility NN cord-010119-t1x9gknd 3641 3 of of IN cord-010119-t1x9gknd 3641 4 transmitting transmit VBG cord-010119-t1x9gknd 3641 5 infectious infectious JJ cord-010119-t1x9gknd 3641 6 organisms organism NNS cord-010119-t1x9gknd 3641 7 via via IN cord-010119-t1x9gknd 3641 8 blood blood NN cord-010119-t1x9gknd 3641 9 products product NNS cord-010119-t1x9gknd 3641 10 , , , cord-010119-t1x9gknd 3641 11 plasma plasma NN cord-010119-t1x9gknd 3641 12 and and CC cord-010119-t1x9gknd 3641 13 their -PRON- PRP$ cord-010119-t1x9gknd 3641 14 derivatives derivative NNS cord-010119-t1x9gknd 3641 15 is be VBZ cord-010119-t1x9gknd 3641 16 a a DT cord-010119-t1x9gknd 3641 17 major major JJ cord-010119-t1x9gknd 3641 18 public public JJ cord-010119-t1x9gknd 3641 19 health health NN cord-010119-t1x9gknd 3641 20 concern concern NN cord-010119-t1x9gknd 3641 21 . . . cord-010119-t1x9gknd 3642 1 While while IN cord-010119-t1x9gknd 3642 2 current current JJ cord-010119-t1x9gknd 3642 3 screening screening NN cord-010119-t1x9gknd 3642 4 measures measure NNS cord-010119-t1x9gknd 3642 5 have have VBP cord-010119-t1x9gknd 3642 6 considerably considerably RB cord-010119-t1x9gknd 3642 7 improved improve VBN cord-010119-t1x9gknd 3642 8 transfusion transfusion NN cord-010119-t1x9gknd 3642 9 safety safety NN cord-010119-t1x9gknd 3642 10 by by IN cord-010119-t1x9gknd 3642 11 reducing reduce VBG cord-010119-t1x9gknd 3642 12 the the DT cord-010119-t1x9gknd 3642 13 risks risk NNS cord-010119-t1x9gknd 3642 14 associated associate VBN cord-010119-t1x9gknd 3642 15 with with IN cord-010119-t1x9gknd 3642 16 known know VBN cord-010119-t1x9gknd 3642 17 pathogens pathogen NNS cord-010119-t1x9gknd 3642 18 , , , cord-010119-t1x9gknd 3642 19 they -PRON- PRP cord-010119-t1x9gknd 3642 20 can can MD cord-010119-t1x9gknd 3642 21 not not RB cord-010119-t1x9gknd 3642 22 protect protect VB cord-010119-t1x9gknd 3642 23 from from IN cord-010119-t1x9gknd 3642 24 emerging emerge VBG cord-010119-t1x9gknd 3642 25 infectious infectious JJ cord-010119-t1x9gknd 3642 26 threats threat NNS cord-010119-t1x9gknd 3642 27 . . . cord-010119-t1x9gknd 3643 1 The the DT cord-010119-t1x9gknd 3643 2 Pathogen Pathogen NNP cord-010119-t1x9gknd 3643 3 Reduction Reduction NNP cord-010119-t1x9gknd 3643 4 Technology Technology NNP cord-010119-t1x9gknd 3643 5 ( ( -LRB- cord-010119-t1x9gknd 3643 6 PRT PRT NNP cord-010119-t1x9gknd 3643 7 ) ) -RRB- cord-010119-t1x9gknd 3643 8 represents represent VBZ cord-010119-t1x9gknd 3643 9 a a DT cord-010119-t1x9gknd 3643 10 proactive proactive JJ cord-010119-t1x9gknd 3643 11 strategy strategy NN cord-010119-t1x9gknd 3643 12 to to TO cord-010119-t1x9gknd 3643 13 further further RB cord-010119-t1x9gknd 3643 14 reduce reduce VB cord-010119-t1x9gknd 3643 15 transfusion transfusion NN cord-010119-t1x9gknd 3643 16 - - HYPH cord-010119-t1x9gknd 3643 17 transmitted transmit VBN cord-010119-t1x9gknd 3643 18 infectious infectious JJ cord-010119-t1x9gknd 3643 19 risk risk NN cord-010119-t1x9gknd 3643 20 . . . cord-010119-t1x9gknd 3644 1 However however RB cord-010119-t1x9gknd 3644 2 , , , cord-010119-t1x9gknd 3644 3 the the DT cord-010119-t1x9gknd 3644 4 scientific scientific JJ cord-010119-t1x9gknd 3644 5 community community NN cord-010119-t1x9gknd 3644 6 broadly broadly RB cord-010119-t1x9gknd 3644 7 agrees agree VBZ cord-010119-t1x9gknd 3644 8 over over IN cord-010119-t1x9gknd 3644 9 the the DT cord-010119-t1x9gknd 3644 10 fact fact NN cord-010119-t1x9gknd 3644 11 that that IN cord-010119-t1x9gknd 3644 12 PRT PRT NNP cord-010119-t1x9gknd 3644 13 has have VBZ cord-010119-t1x9gknd 3644 14 negative negative JJ cord-010119-t1x9gknd 3644 15 impacts impact NNS cord-010119-t1x9gknd 3644 16 on on IN cord-010119-t1x9gknd 3644 17 the the DT cord-010119-t1x9gknd 3644 18 product product NN cord-010119-t1x9gknd 3644 19 's 's POS cord-010119-t1x9gknd 3644 20 quality quality NN cord-010119-t1x9gknd 3644 21 markers marker NNS cord-010119-t1x9gknd 3644 22 . . . cord-010119-t1x9gknd 3645 1 This this DT cord-010119-t1x9gknd 3645 2 study study NN cord-010119-t1x9gknd 3645 3 aims aim VBZ cord-010119-t1x9gknd 3645 4 at at IN cord-010119-t1x9gknd 3645 5 evaluating evaluate VBG cord-010119-t1x9gknd 3645 6 the the DT cord-010119-t1x9gknd 3645 7 impacts impact NNS cord-010119-t1x9gknd 3645 8 of of IN cord-010119-t1x9gknd 3645 9 the the DT cord-010119-t1x9gknd 3645 10 Mirasol Mirasol NNP cord-010119-t1x9gknd 3645 11 PRT PRT NNP cord-010119-t1x9gknd 3645 12 on on IN cord-010119-t1x9gknd 3645 13 platelet platelet NN cord-010119-t1x9gknd 3645 14 ( ( -LRB- cord-010119-t1x9gknd 3645 15 PLT PLT NNP cord-010119-t1x9gknd 3645 16 ) ) -RRB- cord-010119-t1x9gknd 3645 17 quality quality NN cord-010119-t1x9gknd 3645 18 and and CC cord-010119-t1x9gknd 3645 19 PLT PLT NNP cord-010119-t1x9gknd 3645 20 processing processing NN cord-010119-t1x9gknd 3645 21 . . . cord-010119-t1x9gknd 3646 1 Study Study NNP cord-010119-t1x9gknd 3646 2 Design Design NNP cord-010119-t1x9gknd 3646 3 / / SYM cord-010119-t1x9gknd 3646 4 Method method NN cord-010119-t1x9gknd 3646 5 : : : cord-010119-t1x9gknd 3647 1 Two two CD cord-010119-t1x9gknd 3647 2 ABO ABO NNP cord-010119-t1x9gknd 3647 3 - - HYPH cord-010119-t1x9gknd 3647 4 compatible compatible JJ cord-010119-t1x9gknd 3647 5 platelet platelet NN cord-010119-t1x9gknd 3647 6 concentrates concentrate VBZ cord-010119-t1x9gknd 3647 7 ( ( -LRB- cord-010119-t1x9gknd 3647 8 PCs pc NNS cord-010119-t1x9gknd 3647 9 ) ) -RRB- cord-010119-t1x9gknd 3647 10 containing contain VBG cord-010119-t1x9gknd 3647 11 100 100 CD cord-010119-t1x9gknd 3647 12 % % NN cord-010119-t1x9gknd 3647 13 plasma plasma NN cord-010119-t1x9gknd 3647 14 obtained obtain VBN cord-010119-t1x9gknd 3647 15 from from IN cord-010119-t1x9gknd 3647 16 either either CC cord-010119-t1x9gknd 3647 17 apheresis apheresis NN cord-010119-t1x9gknd 3647 18 or or CC cord-010119-t1x9gknd 3647 19 SAGM SAGM NNP cord-010119-t1x9gknd 3647 20 whole whole JJ cord-010119-t1x9gknd 3647 21 blood blood NN cord-010119-t1x9gknd 3647 22 ( ( -LRB- cord-010119-t1x9gknd 3647 23 WB)-derived wb)-derived CD cord-010119-t1x9gknd 3647 24 processing processing NN cord-010119-t1x9gknd 3647 25 were be VBD cord-010119-t1x9gknd 3647 26 paired pair VBN cord-010119-t1x9gknd 3647 27 , , , cord-010119-t1x9gknd 3647 28 pooled pool VBN cord-010119-t1x9gknd 3647 29 and and CC cord-010119-t1x9gknd 3647 30 then then RB cord-010119-t1x9gknd 3647 31 split split VBD cord-010119-t1x9gknd 3647 32 into into IN cord-010119-t1x9gknd 3647 33 two two CD cord-010119-t1x9gknd 3647 34 equal equal JJ cord-010119-t1x9gknd 3647 35 units unit NNS cord-010119-t1x9gknd 3647 36 . . . cord-010119-t1x9gknd 3648 1 One one CD cord-010119-t1x9gknd 3648 2 unit unit NN cord-010119-t1x9gknd 3648 3 was be VBD cord-010119-t1x9gknd 3648 4 used use VBN cord-010119-t1x9gknd 3648 5 as as IN cord-010119-t1x9gknd 3648 6 a a DT cord-010119-t1x9gknd 3648 7 non non JJ cord-010119-t1x9gknd 3648 8 - - JJ cord-010119-t1x9gknd 3648 9 treated treated JJ cord-010119-t1x9gknd 3648 10 control control NN cord-010119-t1x9gknd 3648 11 ( ( -LRB- cord-010119-t1x9gknd 3648 12 CTRL CTRL NNP cord-010119-t1x9gknd 3648 13 ) ) -RRB- cord-010119-t1x9gknd 3648 14 ( ( -LRB- cord-010119-t1x9gknd 3648 15 n56 n56 NNP cord-010119-t1x9gknd 3648 16 ) ) -RRB- cord-010119-t1x9gknd 3648 17 . . . cord-010119-t1x9gknd 3649 1 Riboflavin riboflavin NN cord-010119-t1x9gknd 3649 2 was be VBD cord-010119-t1x9gknd 3649 3 added add VBN cord-010119-t1x9gknd 3649 4 to to IN cord-010119-t1x9gknd 3649 5 the the DT cord-010119-t1x9gknd 3649 6 other other JJ cord-010119-t1x9gknd 3649 7 PC pc NN cord-010119-t1x9gknd 3649 8 unit unit NN cord-010119-t1x9gknd 3649 9 and and CC cord-010119-t1x9gknd 3649 10 then then RB cord-010119-t1x9gknd 3649 11 exposed expose VBN cord-010119-t1x9gknd 3649 12 to to IN cord-010119-t1x9gknd 3649 13 UV uv NN cord-010119-t1x9gknd 3649 14 light light NN cord-010119-t1x9gknd 3649 15 according accord VBG cord-010119-t1x9gknd 3649 16 to to IN cord-010119-t1x9gknd 3649 17 the the DT cord-010119-t1x9gknd 3649 18 manufacturer manufacturer NN cord-010119-t1x9gknd 3649 19 's 's POS cord-010119-t1x9gknd 3649 20 instructions instruction NNS cord-010119-t1x9gknd 3649 21 for for IN cord-010119-t1x9gknd 3649 22 the the DT cord-010119-t1x9gknd 3649 23 Mirasol Mirasol NNP cord-010119-t1x9gknd 3649 24 PRT PRT NNP cord-010119-t1x9gknd 3649 25 ( ( -LRB- cord-010119-t1x9gknd 3649 26 Teru Teru NNP cord-010119-t1x9gknd 3649 27 - - HYPH cord-010119-t1x9gknd 3649 28 moBCT moBCT NNP cord-010119-t1x9gknd 3649 29 ) ) -RRB- cord-010119-t1x9gknd 3650 1 ( ( -LRB- cord-010119-t1x9gknd 3650 2 Test test NN cord-010119-t1x9gknd 3650 3 ) ) -RRB- cord-010119-t1x9gknd 3650 4 ( ( -LRB- cord-010119-t1x9gknd 3650 5 n56 n56 NNP cord-010119-t1x9gknd 3650 6 ) ) -RRB- cord-010119-t1x9gknd 3650 7 . . . cord-010119-t1x9gknd 3651 1 Numerous numerous JJ cord-010119-t1x9gknd 3651 2 in in IN cord-010119-t1x9gknd 3651 3 - - HYPH cord-010119-t1x9gknd 3651 4 vitro vitro FW cord-010119-t1x9gknd 3651 5 quality quality NN cord-010119-t1x9gknd 3651 6 markers marker NNS cord-010119-t1x9gknd 3651 7 ( ( -LRB- cord-010119-t1x9gknd 3651 8 PLT PLT NNP cord-010119-t1x9gknd 3651 9 concentration concentration NN cord-010119-t1x9gknd 3651 10 , , , cord-010119-t1x9gknd 3651 11 ATP ATP NNP cord-010119-t1x9gknd 3651 12 , , , cord-010119-t1x9gknd 3651 13 pO2 pO2 NNP cord-010119-t1x9gknd 3651 14 , , , cord-010119-t1x9gknd 3651 15 pCO2 pCO2 NNP cord-010119-t1x9gknd 3651 16 , , , cord-010119-t1x9gknd 3651 17 pH pH NNP cord-010119-t1x9gknd 3651 18 , , , cord-010119-t1x9gknd 3651 19 glucose glucose NN cord-010119-t1x9gknd 3651 20 , , , cord-010119-t1x9gknd 3651 21 lactate lactate NN cord-010119-t1x9gknd 3651 22 , , , cord-010119-t1x9gknd 3651 23 sodium sodium NN cord-010119-t1x9gknd 3651 24 , , , cord-010119-t1x9gknd 3651 25 and and CC cord-010119-t1x9gknd 3651 26 potassium potassium NN cord-010119-t1x9gknd 3651 27 ) ) -RRB- cord-010119-t1x9gknd 3651 28 were be VBD cord-010119-t1x9gknd 3651 29 measured measure VBN cord-010119-t1x9gknd 3651 30 for for IN cord-010119-t1x9gknd 3651 31 both both DT cord-010119-t1x9gknd 3651 32 Mirasol Mirasol NNP cord-010119-t1x9gknd 3651 33 - - HYPH cord-010119-t1x9gknd 3651 34 treated treat VBN cord-010119-t1x9gknd 3651 35 and and CC cord-010119-t1x9gknd 3651 36 non non JJ cord-010119-t1x9gknd 3651 37 - - JJ cord-010119-t1x9gknd 3651 38 treated treated JJ cord-010119-t1x9gknd 3651 39 PCs pc NNS cord-010119-t1x9gknd 3651 40 on on IN cord-010119-t1x9gknd 3651 41 days day NNS cord-010119-t1x9gknd 3651 42 1 1 CD cord-010119-t1x9gknd 3651 43 , , , cord-010119-t1x9gknd 3651 44 3 3 CD cord-010119-t1x9gknd 3651 45 , , , cord-010119-t1x9gknd 3651 46 5 5 CD cord-010119-t1x9gknd 3651 47 and and CC cord-010119-t1x9gknd 3651 48 7 7 CD cord-010119-t1x9gknd 3651 49 for for IN cord-010119-t1x9gknd 3651 50 apheresis apheresis NN cord-010119-t1x9gknd 3651 51 PCs pc NNS cord-010119-t1x9gknd 3651 52 , , , cord-010119-t1x9gknd 3651 53 and and CC cord-010119-t1x9gknd 3651 54 on on IN cord-010119-t1x9gknd 3651 55 days day NNS cord-010119-t1x9gknd 3651 56 2 2 CD cord-010119-t1x9gknd 3651 57 , , , cord-010119-t1x9gknd 3651 58 3 3 CD cord-010119-t1x9gknd 3651 59 , , , cord-010119-t1x9gknd 3651 60 5 5 CD cord-010119-t1x9gknd 3651 61 and and CC cord-010119-t1x9gknd 3651 62 7 7 CD cord-010119-t1x9gknd 3651 63 for for IN cord-010119-t1x9gknd 3651 64 WB WB NNP cord-010119-t1x9gknd 3651 65 - - HYPH cord-010119-t1x9gknd 3651 66 derived derive VBN cord-010119-t1x9gknd 3651 67 PCs pc NNS cord-010119-t1x9gknd 3651 68 . . . cord-010119-t1x9gknd 3652 1 Two two CD cord-010119-t1x9gknd 3652 2 flow flow NN cord-010119-t1x9gknd 3652 3 cytometry cytometry NN cord-010119-t1x9gknd 3652 4 assays assay NNS cord-010119-t1x9gknd 3652 5 were be VBD cord-010119-t1x9gknd 3652 6 used use VBN cord-010119-t1x9gknd 3652 7 to to TO cord-010119-t1x9gknd 3652 8 evaluate evaluate VB cord-010119-t1x9gknd 3652 9 CD62p CD62p NNP cord-010119-t1x9gknd 3652 10 expression expression NN cord-010119-t1x9gknd 3652 11 with with IN cord-010119-t1x9gknd 3652 12 and and CC cord-010119-t1x9gknd 3652 13 without without IN cord-010119-t1x9gknd 3652 14 thrombin thrombin JJ cord-010119-t1x9gknd 3652 15 activation activation NN cord-010119-t1x9gknd 3652 16 , , , cord-010119-t1x9gknd 3652 17 and and CC cord-010119-t1x9gknd 3652 18 to to TO cord-010119-t1x9gknd 3652 19 measure measure VB cord-010119-t1x9gknd 3652 20 the the DT cord-010119-t1x9gknd 3652 21 percent percent NN cord-010119-t1x9gknd 3652 22 annexin annexin NN cord-010119-t1x9gknd 3652 23 Vpositive Vpositive NNP cord-010119-t1x9gknd 3652 24 PLT PLT NNP cord-010119-t1x9gknd 3652 25 . . . cord-010119-t1x9gknd 3653 1 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 3653 2 2017 2017 CD cord-010119-t1x9gknd 3653 3 Vol Vol NNP cord-010119-t1x9gknd 3653 4 . . . cord-010119-t1x9gknd 3654 1 57 57 CD cord-010119-t1x9gknd 3655 1 Supplement supplement NN cord-010119-t1x9gknd 3655 2 S3 s3 NN cord-010119-t1x9gknd 3655 3 Results/ Results/ . cord-010119-t1x9gknd 3656 1 Finding finding NN cord-010119-t1x9gknd 3656 2 : : : cord-010119-t1x9gknd 3656 3 Platelet platelet NN cord-010119-t1x9gknd 3656 4 recovery recovery NN cord-010119-t1x9gknd 3656 5 was be VBD cord-010119-t1x9gknd 3656 6 92 92 CD cord-010119-t1x9gknd 3656 7 6 6 CD cord-010119-t1x9gknd 3656 8 5 5 CD cord-010119-t1x9gknd 3656 9 % % NN cord-010119-t1x9gknd 3656 10 and and CC cord-010119-t1x9gknd 3656 11 81 81 CD cord-010119-t1x9gknd 3656 12 6 6 CD cord-010119-t1x9gknd 3656 13 10 10 CD cord-010119-t1x9gknd 3656 14 % % NN cord-010119-t1x9gknd 3656 15 for for IN cord-010119-t1x9gknd 3656 16 apheresis apheresis NN cord-010119-t1x9gknd 3656 17 and and CC cord-010119-t1x9gknd 3656 18 WB WB NNP cord-010119-t1x9gknd 3656 19 - - HYPH cord-010119-t1x9gknd 3656 20 derived derive VBN cord-010119-t1x9gknd 3656 21 PCs pc NNS cord-010119-t1x9gknd 3656 22 , , , cord-010119-t1x9gknd 3656 23 respectively respectively RB cord-010119-t1x9gknd 3656 24 . . . cord-010119-t1x9gknd 3657 1 Mirasol Mirasol NNP cord-010119-t1x9gknd 3657 2 - - HYPH cord-010119-t1x9gknd 3657 3 treated treat VBN cord-010119-t1x9gknd 3657 4 PCs pc NNS cord-010119-t1x9gknd 3657 5 showed show VBD cord-010119-t1x9gknd 3657 6 higher high JJR cord-010119-t1x9gknd 3657 7 levels level NNS cord-010119-t1x9gknd 3657 8 of of IN cord-010119-t1x9gknd 3657 9 annexin annexin NN cord-010119-t1x9gknd 3657 10 V v NN cord-010119-t1x9gknd 3657 11 - - HYPH cord-010119-t1x9gknd 3657 12 positive positive JJ cord-010119-t1x9gknd 3657 13 cells cell NNS cord-010119-t1x9gknd 3657 14 ( ( -LRB- cord-010119-t1x9gknd 3657 15 3 3 CD cord-010119-t1x9gknd 3657 16 % % NN cord-010119-t1x9gknd 3657 17 6 6 CD cord-010119-t1x9gknd 3657 18 1 1 CD cord-010119-t1x9gknd 3657 19 ( ( -LRB- cord-010119-t1x9gknd 3657 20 Test test NN cord-010119-t1x9gknd 3657 21 ) ) -RRB- cord-010119-t1x9gknd 3657 22 , , , cord-010119-t1x9gknd 3657 23 vs. vs. IN cord-010119-t1x9gknd 3657 24 1.7 1.7 CD cord-010119-t1x9gknd 3657 25 % % NN cord-010119-t1x9gknd 3657 26 6 6 CD cord-010119-t1x9gknd 3657 27 0.5 0.5 CD cord-010119-t1x9gknd 3657 28 ( ( -LRB- cord-010119-t1x9gknd 3657 29 CTL CTL NNP cord-010119-t1x9gknd 3657 30 ) ) -RRB- cord-010119-t1x9gknd 3657 31 on on IN cord-010119-t1x9gknd 3657 32 day day NN cord-010119-t1x9gknd 3657 33 5 5 CD cord-010119-t1x9gknd 3657 34 ) ) -RRB- cord-010119-t1x9gknd 3657 35 and and CC cord-010119-t1x9gknd 3657 36 a a DT cord-010119-t1x9gknd 3657 37 higher high JJR cord-010119-t1x9gknd 3657 38 rate rate NN cord-010119-t1x9gknd 3657 39 of of IN cord-010119-t1x9gknd 3657 40 CD62p CD62p NNP cord-010119-t1x9gknd 3657 41 expression expression NN cord-010119-t1x9gknd 3657 42 than than IN cord-010119-t1x9gknd 3657 43 control control NN cord-010119-t1x9gknd 3657 44 PC pc NN cord-010119-t1x9gknd 3657 45 units unit NNS cord-010119-t1x9gknd 3657 46 ( ( -LRB- cord-010119-t1x9gknd 3657 47 58 58 CD cord-010119-t1x9gknd 3657 48 % % NN cord-010119-t1x9gknd 3657 49 6 6 CD cord-010119-t1x9gknd 3657 50 7 7 CD cord-010119-t1x9gknd 3657 51 ( ( -LRB- cord-010119-t1x9gknd 3657 52 Test test NN cord-010119-t1x9gknd 3657 53 ) ) -RRB- cord-010119-t1x9gknd 3657 54 , , , cord-010119-t1x9gknd 3657 55 vs. vs. FW cord-010119-t1x9gknd 3657 56 23 23 CD cord-010119-t1x9gknd 3657 57 % % NN cord-010119-t1x9gknd 3657 58 6 6 CD cord-010119-t1x9gknd 3657 59 6 6 CD cord-010119-t1x9gknd 3657 60 ( ( -LRB- cord-010119-t1x9gknd 3657 61 CTL CTL NNP cord-010119-t1x9gknd 3657 62 ) ) -RRB- cord-010119-t1x9gknd 3657 63 ) ) -RRB- cord-010119-t1x9gknd 3657 64 on on IN cord-010119-t1x9gknd 3657 65 day day NN cord-010119-t1x9gknd 3657 66 5 5 CD cord-010119-t1x9gknd 3657 67 ) ) -RRB- cord-010119-t1x9gknd 3657 68 . . . cord-010119-t1x9gknd 3658 1 The the DT cord-010119-t1x9gknd 3658 2 Mirasol Mirasol NNP cord-010119-t1x9gknd 3658 3 treatment treatment NN cord-010119-t1x9gknd 3658 4 generates generate VBZ cord-010119-t1x9gknd 3658 5 changes change NNS cord-010119-t1x9gknd 3658 6 in in IN cord-010119-t1x9gknd 3658 7 pH pH NNP cord-010119-t1x9gknd 3658 8 , , , cord-010119-t1x9gknd 3658 9 glucose glucose NN cord-010119-t1x9gknd 3658 10 and and CC cord-010119-t1x9gknd 3658 11 lactate lactate NN cord-010119-t1x9gknd 3658 12 for for IN cord-010119-t1x9gknd 3658 13 PCs pc NNS cord-010119-t1x9gknd 3658 14 during during IN cord-010119-t1x9gknd 3658 15 storage storage NN cord-010119-t1x9gknd 3658 16 . . . cord-010119-t1x9gknd 3659 1 Conclusion conclusion NN cord-010119-t1x9gknd 3659 2 : : : cord-010119-t1x9gknd 3660 1 The the DT cord-010119-t1x9gknd 3660 2 Mirasol Mirasol NNP cord-010119-t1x9gknd 3660 3 treatment treatment NN cord-010119-t1x9gknd 3660 4 induces induce VBZ cord-010119-t1x9gknd 3660 5 a a DT cord-010119-t1x9gknd 3660 6 loss loss NN cord-010119-t1x9gknd 3660 7 in in IN cord-010119-t1x9gknd 3660 8 the the DT cord-010119-t1x9gknd 3660 9 net net JJ cord-010119-t1x9gknd 3660 10 number number NN cord-010119-t1x9gknd 3660 11 of of IN cord-010119-t1x9gknd 3660 12 PLTs plt NNS cord-010119-t1x9gknd 3660 13 / / SYM cord-010119-t1x9gknd 3660 14 unit unit NN cord-010119-t1x9gknd 3660 15 and and CC cord-010119-t1x9gknd 3660 16 elevated elevated JJ cord-010119-t1x9gknd 3660 17 platelet platelet NN cord-010119-t1x9gknd 3660 18 activation activation NN cord-010119-t1x9gknd 3660 19 . . . cord-010119-t1x9gknd 3661 1 Changes change NNS cord-010119-t1x9gknd 3661 2 in in IN cord-010119-t1x9gknd 3661 3 pH pH NNP cord-010119-t1x9gknd 3661 4 , , , cord-010119-t1x9gknd 3661 5 glucose glucose NN cord-010119-t1x9gknd 3661 6 and and CC cord-010119-t1x9gknd 3661 7 lactate lactate NN cord-010119-t1x9gknd 3661 8 suggest suggest VBP cord-010119-t1x9gknd 3661 9 that that IN cord-010119-t1x9gknd 3661 10 PRT PRT NNP cord-010119-t1x9gknd 3661 11 affects affect VBZ cord-010119-t1x9gknd 3661 12 PLT PLT NNP cord-010119-t1x9gknd 3661 13 metabolism metabolism NN cord-010119-t1x9gknd 3661 14 . . . cord-010119-t1x9gknd 3662 1 Finally finally RB cord-010119-t1x9gknd 3662 2 , , , cord-010119-t1x9gknd 3662 3 PRT PRT NNP cord-010119-t1x9gknd 3662 4 has have VBZ cord-010119-t1x9gknd 3662 5 numerous numerous JJ cord-010119-t1x9gknd 3662 6 impacts impact NNS cord-010119-t1x9gknd 3662 7 on on IN cord-010119-t1x9gknd 3662 8 logistic logistic JJ cord-010119-t1x9gknd 3662 9 , , , cord-010119-t1x9gknd 3662 10 storage storage NN cord-010119-t1x9gknd 3662 11 and and CC cord-010119-t1x9gknd 3662 12 processing processing NN cord-010119-t1x9gknd 3662 13 time time NN cord-010119-t1x9gknd 3662 14 constraints constraint NNS cord-010119-t1x9gknd 3662 15 of of IN cord-010119-t1x9gknd 3662 16 blood blood NN cord-010119-t1x9gknd 3662 17 bank bank NN cord-010119-t1x9gknd 3662 18 operations operation NNS cord-010119-t1x9gknd 3662 19 . . . cord-010119-t1x9gknd 3663 1 Nevertheless nevertheless RB cord-010119-t1x9gknd 3663 2 , , , cord-010119-t1x9gknd 3663 3 the the DT cord-010119-t1x9gknd 3663 4 Mirasol Mirasol NNP cord-010119-t1x9gknd 3663 5 PRT PRT NNP cord-010119-t1x9gknd 3663 6 is be VBZ cord-010119-t1x9gknd 3663 7 routinely routinely RB cord-010119-t1x9gknd 3663 8 used use VBN cord-010119-t1x9gknd 3663 9 in in IN cord-010119-t1x9gknd 3663 10 Europe Europe NNP cord-010119-t1x9gknd 3663 11 with with IN cord-010119-t1x9gknd 3663 12 acceptable acceptable JJ cord-010119-t1x9gknd 3663 13 clinical clinical JJ cord-010119-t1x9gknd 3663 14 outcomes outcome NNS cord-010119-t1x9gknd 3663 15 . . . cord-010119-t1x9gknd 3664 1 Evaluation evaluation NN cord-010119-t1x9gknd 3664 2 of of IN cord-010119-t1x9gknd 3664 3 a a DT cord-010119-t1x9gknd 3664 4 Test test NN cord-010119-t1x9gknd 3664 5 Method method NN cord-010119-t1x9gknd 3664 6 to to TO cord-010119-t1x9gknd 3664 7 Detect detect VB cord-010119-t1x9gknd 3664 8 Bacterial bacterial JJ cord-010119-t1x9gknd 3664 9 Contamination contamination NN cord-010119-t1x9gknd 3664 10 in in IN cord-010119-t1x9gknd 3664 11 Platelets Platelets NNPS cord-010119-t1x9gknd 3664 12 ; ; : cord-010119-t1x9gknd 3664 13 Bactx Bactx NNP cord-010119-t1x9gknd 3664 14 TM TM NNP cord-010119-t1x9gknd 3664 15 Assay Assay NNP cord-010119-t1x9gknd 3664 16 Ji Ji NNP cord-010119-t1x9gknd 3664 17 Hye Hye NNP cord-010119-t1x9gknd 3664 18 Park Park NNP cord-010119-t1x9gknd 3664 19 Sexton Sexton NNP cord-010119-t1x9gknd 3665 1 * * NFP cord-010119-t1x9gknd 3665 2 1 1 CD cord-010119-t1x9gknd 3665 3 , , , cord-010119-t1x9gknd 3665 4 Lorraine Lorraine NNP cord-010119-t1x9gknd 3665 5 Blagg Blagg NNP cord-010119-t1x9gknd 3665 6 2 2 CD cord-010119-t1x9gknd 3665 7 , , , cord-010119-t1x9gknd 3665 8 Christi Christi NNP cord-010119-t1x9gknd 3665 9 E E NNP cord-010119-t1x9gknd 3665 10 Marshall Marshall NNP cord-010119-t1x9gknd 3665 11 1 1 CD cord-010119-t1x9gknd 3665 12 , , , cord-010119-t1x9gknd 3665 13 Herman Herman NNP cord-010119-t1x9gknd 3665 14 Woodson Woodson NNP cord-010119-t1x9gknd 3665 15 1 1 CD cord-010119-t1x9gknd 3665 16 , , , cord-010119-t1x9gknd 3665 17 Sean Sean NNP cord-010119-t1x9gknd 3665 18 Erony Erony NNP cord-010119-t1x9gknd 3665 19 1 1 CD cord-010119-t1x9gknd 3665 20 , , , cord-010119-t1x9gknd 3665 21 Krishna Krishna NNP cord-010119-t1x9gknd 3665 22 Patel Patel NNP cord-010119-t1x9gknd 3665 23 1 1 CD cord-010119-t1x9gknd 3665 24 and and CC cord-010119-t1x9gknd 3665 25 Eric Eric NNP cord-010119-t1x9gknd 3665 26 Gehrie Gehrie NNP cord-010119-t1x9gknd 3665 27 3 3 CD cord-010119-t1x9gknd 3665 28 . . . cord-010119-t1x9gknd 3665 29 1 1 CD cord-010119-t1x9gknd 3666 1 The the DT cord-010119-t1x9gknd 3666 2 Johns Johns NNP cord-010119-t1x9gknd 3666 3 Hopkins Hopkins NNP cord-010119-t1x9gknd 3666 4 Hospital Hospital NNP cord-010119-t1x9gknd 3666 5 , , , cord-010119-t1x9gknd 3666 6 2 2 CD cord-010119-t1x9gknd 3666 7 Johns Johns NNP cord-010119-t1x9gknd 3666 8 Hopkins Hopkins NNP cord-010119-t1x9gknd 3666 9 Hospital Hospital NNP cord-010119-t1x9gknd 3666 10 Transfusion Transfusion NNP cord-010119-t1x9gknd 3666 11 Medicine Medicine NNP cord-010119-t1x9gknd 3666 12 Dept Dept NNP cord-010119-t1x9gknd 3666 13 , , , cord-010119-t1x9gknd 3666 14 3 3 CD cord-010119-t1x9gknd 3666 15 Johns Johns NNP cord-010119-t1x9gknd 3666 16 Hopkins Hopkins NNP cord-010119-t1x9gknd 3666 17 University University NNP cord-010119-t1x9gknd 3666 18 School School NNP cord-010119-t1x9gknd 3666 19 of of IN cord-010119-t1x9gknd 3666 20 Medicine Medicine NNP cord-010119-t1x9gknd 3666 21 Background Background NNP cord-010119-t1x9gknd 3666 22 / / SYM cord-010119-t1x9gknd 3666 23 Case Case NNP cord-010119-t1x9gknd 3666 24 Studies Studies NNPS cord-010119-t1x9gknd 3666 25 : : : cord-010119-t1x9gknd 3666 26 Bacterial bacterial JJ cord-010119-t1x9gknd 3666 27 contamination contamination NN cord-010119-t1x9gknd 3666 28 of of IN cord-010119-t1x9gknd 3666 29 platelets platelet NNS cord-010119-t1x9gknd 3666 30 ( ( -LRB- cord-010119-t1x9gknd 3666 31 PLTs PLTs NNP cord-010119-t1x9gknd 3666 32 ) ) -RRB- cord-010119-t1x9gknd 3666 33 is be VBZ cord-010119-t1x9gknd 3666 34 the the DT cord-010119-t1x9gknd 3666 35 leading lead VBG cord-010119-t1x9gknd 3666 36 infectious infectious JJ cord-010119-t1x9gknd 3666 37 risk risk NN cord-010119-t1x9gknd 3666 38 of of IN cord-010119-t1x9gknd 3666 39 platelet platelet NN cord-010119-t1x9gknd 3666 40 transfusion transfusion NN cord-010119-t1x9gknd 3666 41 therapy therapy NN cord-010119-t1x9gknd 3666 42 and and CC cord-010119-t1x9gknd 3666 43 it -PRON- PRP cord-010119-t1x9gknd 3666 44 is be VBZ cord-010119-t1x9gknd 3666 45 the the DT cord-010119-t1x9gknd 3666 46 most most RBS cord-010119-t1x9gknd 3666 47 significant significant JJ cord-010119-t1x9gknd 3666 48 infectious infectious JJ cord-010119-t1x9gknd 3666 49 cause cause NN cord-010119-t1x9gknd 3666 50 of of IN cord-010119-t1x9gknd 3666 51 transmission transmission NN cord-010119-t1x9gknd 3666 52 - - HYPH cord-010119-t1x9gknd 3666 53 associated associate VBN cord-010119-t1x9gknd 3666 54 morbidity morbidity NN cord-010119-t1x9gknd 3666 55 and and CC cord-010119-t1x9gknd 3666 56 mortality mortality NN cord-010119-t1x9gknd 3666 57 . . . cord-010119-t1x9gknd 3667 1 Therefore therefore RB cord-010119-t1x9gknd 3667 2 , , , cord-010119-t1x9gknd 3667 3 detecting detect VBG cord-010119-t1x9gknd 3667 4 various various JJ cord-010119-t1x9gknd 3667 5 potential potential JJ cord-010119-t1x9gknd 3667 6 bacterial bacterial JJ cord-010119-t1x9gknd 3667 7 contaminants contaminant NNS cord-010119-t1x9gknd 3667 8 in in IN cord-010119-t1x9gknd 3667 9 platelets platelet NNS cord-010119-t1x9gknd 3667 10 in in IN cord-010119-t1x9gknd 3667 11 a a DT cord-010119-t1x9gknd 3667 12 timely timely JJ cord-010119-t1x9gknd 3667 13 manner manner NN cord-010119-t1x9gknd 3667 14 is be VBZ cord-010119-t1x9gknd 3667 15 critical critical JJ cord-010119-t1x9gknd 3667 16 . . . cord-010119-t1x9gknd 3668 1 The the DT cord-010119-t1x9gknd 3668 2 BacTx BacTx NNP cord-010119-t1x9gknd 3668 3 assay assay NN cord-010119-t1x9gknd 3668 4 is be VBZ cord-010119-t1x9gknd 3668 5 a a DT cord-010119-t1x9gknd 3668 6 rapid rapid JJ cord-010119-t1x9gknd 3668 7 colorimetric colorimetric JJ cord-010119-t1x9gknd 3668 8 assay assay NN cord-010119-t1x9gknd 3668 9 that that WDT cord-010119-t1x9gknd 3668 10 detects detect VBZ cord-010119-t1x9gknd 3668 11 peptidoglycan peptidoglycan NN cord-010119-t1x9gknd 3668 12 , , , cord-010119-t1x9gknd 3668 13 a a DT cord-010119-t1x9gknd 3668 14 cell cell NN cord-010119-t1x9gknd 3668 15 wall wall NN cord-010119-t1x9gknd 3668 16 component component NN cord-010119-t1x9gknd 3668 17 of of IN cord-010119-t1x9gknd 3668 18 both both DT cord-010119-t1x9gknd 3668 19 gram gram NN cord-010119-t1x9gknd 3668 20 - - HYPH cord-010119-t1x9gknd 3668 21 positive positive JJ cord-010119-t1x9gknd 3668 22 and and CC cord-010119-t1x9gknd 3668 23 gram gram JJ cord-010119-t1x9gknd 3668 24 - - HYPH cord-010119-t1x9gknd 3668 25 negative negative JJ cord-010119-t1x9gknd 3668 26 bacteria bacteria NNS cord-010119-t1x9gknd 3668 27 . . . cord-010119-t1x9gknd 3669 1 Here here RB cord-010119-t1x9gknd 3669 2 , , , cord-010119-t1x9gknd 3669 3 we -PRON- PRP cord-010119-t1x9gknd 3669 4 report report VBP cord-010119-t1x9gknd 3669 5 an an DT cord-010119-t1x9gknd 3669 6 analysis analysis NN cord-010119-t1x9gknd 3669 7 of of IN cord-010119-t1x9gknd 3669 8 the the DT cord-010119-t1x9gknd 3669 9 BacTx BacTx NNP cord-010119-t1x9gknd 3669 10 assay assay NN cord-010119-t1x9gknd 3669 11 at at IN cord-010119-t1x9gknd 3669 12 our -PRON- PRP$ cord-010119-t1x9gknd 3669 13 hospital hospital NN cord-010119-t1x9gknd 3669 14 . . . cord-010119-t1x9gknd 3670 1 Study Study NNP cord-010119-t1x9gknd 3670 2 Design Design NNP cord-010119-t1x9gknd 3670 3 / / SYM cord-010119-t1x9gknd 3670 4 Method method NN cord-010119-t1x9gknd 3670 5 : : : cord-010119-t1x9gknd 3670 6 We -PRON- PRP cord-010119-t1x9gknd 3670 7 aimed aim VBD cord-010119-t1x9gknd 3670 8 to to TO cord-010119-t1x9gknd 3670 9 determine determine VB cord-010119-t1x9gknd 3670 10 the the DT cord-010119-t1x9gknd 3670 11 sensitivity sensitivity NN cord-010119-t1x9gknd 3670 12 and and CC cord-010119-t1x9gknd 3670 13 specificity specificity NN cord-010119-t1x9gknd 3670 14 of of IN cord-010119-t1x9gknd 3670 15 the the DT cord-010119-t1x9gknd 3670 16 BacTx BacTx NNP cord-010119-t1x9gknd 3670 17 assay assay NN cord-010119-t1x9gknd 3670 18 . . . cord-010119-t1x9gknd 3671 1 340 340 CD cord-010119-t1x9gknd 3671 2 intact intact JJ cord-010119-t1x9gknd 3671 3 leukoreduced leukoreduce VBN cord-010119-t1x9gknd 3671 4 apheresis apheresis NN cord-010119-t1x9gknd 3671 5 PLT PLT NNP cord-010119-t1x9gknd 3671 6 ( ( -LRB- cord-010119-t1x9gknd 3671 7 LRAP LRAP NNP cord-010119-t1x9gknd 3671 8 ) ) -RRB- cord-010119-t1x9gknd 3671 9 units unit NNS cord-010119-t1x9gknd 3671 10 were be VBD cord-010119-t1x9gknd 3671 11 tested test VBN cord-010119-t1x9gknd 3671 12 by by IN cord-010119-t1x9gknd 3671 13 BacTx BacTx NNP cord-010119-t1x9gknd 3671 14 at at IN cord-010119-t1x9gknd 3671 15 storage storage NN cord-010119-t1x9gknd 3671 16 day day NN cord-010119-t1x9gknd 3671 17 4 4 CD cord-010119-t1x9gknd 3671 18 . . . cord-010119-t1x9gknd 3672 1 As as IN cord-010119-t1x9gknd 3672 2 a a DT cord-010119-t1x9gknd 3672 3 control control NN cord-010119-t1x9gknd 3672 4 , , , cord-010119-t1x9gknd 3672 5 each each DT cord-010119-t1x9gknd 3672 6 intact intact JJ cord-010119-t1x9gknd 3672 7 LRAP LRAP NNP cord-010119-t1x9gknd 3672 8 was be VBD cord-010119-t1x9gknd 3672 9 also also RB cord-010119-t1x9gknd 3672 10 cultured culture VBN cord-010119-t1x9gknd 3672 11 by by IN cord-010119-t1x9gknd 3672 12 an an DT cord-010119-t1x9gknd 3672 13 automated automate VBN cord-010119-t1x9gknd 3672 14 bacterial bacterial JJ cord-010119-t1x9gknd 3672 15 detection detection NN cord-010119-t1x9gknd 3672 16 system system NN cord-010119-t1x9gknd 3672 17 ( ( -LRB- cord-010119-t1x9gknd 3672 18 BacT BacT NNP cord-010119-t1x9gknd 3672 19 culture culture NN cord-010119-t1x9gknd 3672 20 ) ) -RRB- cord-010119-t1x9gknd 3672 21 on on IN cord-010119-t1x9gknd 3672 22 storage storage NN cord-010119-t1x9gknd 3672 23 day day NN cord-010119-t1x9gknd 3672 24 3 3 CD cord-010119-t1x9gknd 3672 25 . . . cord-010119-t1x9gknd 3673 1 The the DT cord-010119-t1x9gknd 3673 2 results result NNS cord-010119-t1x9gknd 3673 3 of of IN cord-010119-t1x9gknd 3673 4 the the DT cord-010119-t1x9gknd 3673 5 BacTx BacTx NNP cord-010119-t1x9gknd 3673 6 test test NN cord-010119-t1x9gknd 3673 7 were be VBD cord-010119-t1x9gknd 3673 8 compared compare VBN cord-010119-t1x9gknd 3673 9 to to IN cord-010119-t1x9gknd 3673 10 the the DT cord-010119-t1x9gknd 3673 11 results result NNS cord-010119-t1x9gknd 3673 12 of of IN cord-010119-t1x9gknd 3673 13 the the DT cord-010119-t1x9gknd 3673 14 BacT BacT NNP cord-010119-t1x9gknd 3673 15 culture culture NN cord-010119-t1x9gknd 3673 16 system system NN cord-010119-t1x9gknd 3673 17 . . . cord-010119-t1x9gknd 3674 1 Results result NNS cord-010119-t1x9gknd 3674 2 / / SYM cord-010119-t1x9gknd 3674 3 Finding finding NN cord-010119-t1x9gknd 3674 4 : : : cord-010119-t1x9gknd 3674 5 A a DT cord-010119-t1x9gknd 3674 6 total total NN cord-010119-t1x9gknd 3674 7 of of IN cord-010119-t1x9gknd 3674 8 340 340 CD cord-010119-t1x9gknd 3674 9 LRAP LRAP NNP cord-010119-t1x9gknd 3674 10 were be VBD cord-010119-t1x9gknd 3674 11 tested test VBN cord-010119-t1x9gknd 3674 12 . . . cord-010119-t1x9gknd 3675 1 335 335 CD cord-010119-t1x9gknd 3675 2 LRAPs lrap NNS cord-010119-t1x9gknd 3675 3 initially initially RB cord-010119-t1x9gknd 3675 4 tested test VBD cord-010119-t1x9gknd 3675 5 negative negative JJ cord-010119-t1x9gknd 3675 6 by by IN cord-010119-t1x9gknd 3675 7 BacTx BacTx NNP cord-010119-t1x9gknd 3675 8 , , , cord-010119-t1x9gknd 3675 9 while while IN cord-010119-t1x9gknd 3675 10 5 5 CD cord-010119-t1x9gknd 3675 11 LRAPs lrap NNS cord-010119-t1x9gknd 3675 12 initially initially RB cord-010119-t1x9gknd 3675 13 tested test VBD cord-010119-t1x9gknd 3675 14 positive positive JJ cord-010119-t1x9gknd 3675 15 by by IN cord-010119-t1x9gknd 3675 16 BacTx BacTx NNP cord-010119-t1x9gknd 3675 17 . . . cord-010119-t1x9gknd 3676 1 All all DT cord-010119-t1x9gknd 3676 2 5 5 CD cord-010119-t1x9gknd 3676 3 initial initial JJ cord-010119-t1x9gknd 3676 4 positive positive JJ cord-010119-t1x9gknd 3676 5 BacTx BacTx NNP cord-010119-t1x9gknd 3676 6 tests test NNS cord-010119-t1x9gknd 3676 7 were be VBD cord-010119-t1x9gknd 3676 8 negative negative JJ cord-010119-t1x9gknd 3676 9 when when WRB cord-010119-t1x9gknd 3676 10 subjected subject VBN cord-010119-t1x9gknd 3676 11 to to TO cord-010119-t1x9gknd 3676 12 repeat repeat VB cord-010119-t1x9gknd 3676 13 testing testing NN cord-010119-t1x9gknd 3676 14 . . . cord-010119-t1x9gknd 3677 1 In in IN cord-010119-t1x9gknd 3677 2 contrast contrast NN cord-010119-t1x9gknd 3677 3 , , , cord-010119-t1x9gknd 3677 4 all all DT cord-010119-t1x9gknd 3677 5 LRAPs lrap NNS cord-010119-t1x9gknd 3677 6 tested test VBD cord-010119-t1x9gknd 3677 7 negative negative JJ cord-010119-t1x9gknd 3677 8 with with IN cord-010119-t1x9gknd 3677 9 the the DT cord-010119-t1x9gknd 3677 10 BacT BacT NNP cord-010119-t1x9gknd 3677 11 culture culture NN cord-010119-t1x9gknd 3677 12 system system NN cord-010119-t1x9gknd 3677 13 . . . cord-010119-t1x9gknd 3678 1 The the DT cord-010119-t1x9gknd 3678 2 specificity specificity NN cord-010119-t1x9gknd 3678 3 of of IN cord-010119-t1x9gknd 3678 4 the the DT cord-010119-t1x9gknd 3678 5 BacTx BacTx NNP cord-010119-t1x9gknd 3678 6 test test NN cord-010119-t1x9gknd 3678 7 was be VBD cord-010119-t1x9gknd 3678 8 98.5 98.5 CD cord-010119-t1x9gknd 3678 9 % % NN cord-010119-t1x9gknd 3678 10 . . . cord-010119-t1x9gknd 3679 1 We -PRON- PRP cord-010119-t1x9gknd 3679 2 did do VBD cord-010119-t1x9gknd 3679 3 not not RB cord-010119-t1x9gknd 3679 4 have have VB cord-010119-t1x9gknd 3679 5 any any DT cord-010119-t1x9gknd 3679 6 true true JJ cord-010119-t1x9gknd 3679 7 positive positive JJ cord-010119-t1x9gknd 3679 8 test test NN cord-010119-t1x9gknd 3679 9 results result NNS cord-010119-t1x9gknd 3679 10 ; ; : cord-010119-t1x9gknd 3679 11 therefore therefore RB cord-010119-t1x9gknd 3679 12 , , , cord-010119-t1x9gknd 3679 13 the the DT cord-010119-t1x9gknd 3679 14 sensitivity sensitivity NN cord-010119-t1x9gknd 3679 15 of of IN cord-010119-t1x9gknd 3679 16 the the DT cord-010119-t1x9gknd 3679 17 BacTx BacTx NNP cord-010119-t1x9gknd 3679 18 could could MD cord-010119-t1x9gknd 3679 19 not not RB cord-010119-t1x9gknd 3679 20 be be VB cord-010119-t1x9gknd 3679 21 determined determine VBN cord-010119-t1x9gknd 3679 22 . . . cord-010119-t1x9gknd 3680 1 Conclusion conclusion NN cord-010119-t1x9gknd 3680 2 : : : cord-010119-t1x9gknd 3681 1 This this DT cord-010119-t1x9gknd 3681 2 is be VBZ cord-010119-t1x9gknd 3681 3 a a DT cord-010119-t1x9gknd 3681 4 small small JJ cord-010119-t1x9gknd 3681 5 study study NN cord-010119-t1x9gknd 3681 6 of of IN cord-010119-t1x9gknd 3681 7 only only RB cord-010119-t1x9gknd 3681 8 340 340 CD cord-010119-t1x9gknd 3681 9 platelet platelet NN cord-010119-t1x9gknd 3681 10 units unit NNS cord-010119-t1x9gknd 3681 11 . . . cord-010119-t1x9gknd 3682 1 The the DT cord-010119-t1x9gknd 3682 2 expected expect VBN cord-010119-t1x9gknd 3682 3 rate rate NN cord-010119-t1x9gknd 3682 4 of of IN cord-010119-t1x9gknd 3682 5 bacterial bacterial JJ cord-010119-t1x9gknd 3682 6 contamination contamination NN cord-010119-t1x9gknd 3682 7 of of IN cord-010119-t1x9gknd 3682 8 platelets platelet NNS cord-010119-t1x9gknd 3682 9 is be VBZ cord-010119-t1x9gknd 3682 10 less less JJR cord-010119-t1x9gknd 3682 11 than than IN cord-010119-t1x9gknd 3682 12 1 1 CD cord-010119-t1x9gknd 3682 13 per per IN cord-010119-t1x9gknd 3682 14 2000 2000 CD cord-010119-t1x9gknd 3682 15 units unit NNS cord-010119-t1x9gknd 3682 16 . . . cord-010119-t1x9gknd 3683 1 The the DT cord-010119-t1x9gknd 3683 2 1.5 1.5 CD cord-010119-t1x9gknd 3683 3 % % NN cord-010119-t1x9gknd 3683 4 initial initial JJ cord-010119-t1x9gknd 3683 5 positive positive JJ cord-010119-t1x9gknd 3683 6 rate rate NN cord-010119-t1x9gknd 3683 7 was be VBD cord-010119-t1x9gknd 3683 8 therefore therefore RB cord-010119-t1x9gknd 3683 9 higher high JJR cord-010119-t1x9gknd 3683 10 than than IN cord-010119-t1x9gknd 3683 11 expected expect VBN cord-010119-t1x9gknd 3683 12 , , , cord-010119-t1x9gknd 3683 13 but but CC cord-010119-t1x9gknd 3683 14 given give VBN cord-010119-t1x9gknd 3683 15 the the DT cord-010119-t1x9gknd 3683 16 small small JJ cord-010119-t1x9gknd 3683 17 sample sample NN cord-010119-t1x9gknd 3683 18 size size NN cord-010119-t1x9gknd 3683 19 , , , cord-010119-t1x9gknd 3683 20 it -PRON- PRP cord-010119-t1x9gknd 3683 21 is be VBZ cord-010119-t1x9gknd 3683 22 clear clear JJ cord-010119-t1x9gknd 3683 23 that that IN cord-010119-t1x9gknd 3683 24 further further JJ cord-010119-t1x9gknd 3683 25 study study NN cord-010119-t1x9gknd 3683 26 is be VBZ cord-010119-t1x9gknd 3683 27 needed need VBN cord-010119-t1x9gknd 3683 28 to to TO cord-010119-t1x9gknd 3683 29 more more RBR cord-010119-t1x9gknd 3683 30 rigorously rigorously RB cord-010119-t1x9gknd 3683 31 assess assess VB cord-010119-t1x9gknd 3683 32 the the DT cord-010119-t1x9gknd 3683 33 true true JJ cord-010119-t1x9gknd 3683 34 sensitivity sensitivity NN cord-010119-t1x9gknd 3683 35 and and CC cord-010119-t1x9gknd 3683 36 specificity specificity NN cord-010119-t1x9gknd 3683 37 of of IN cord-010119-t1x9gknd 3683 38 the the DT cord-010119-t1x9gknd 3683 39 BacTx BacTx NNP cord-010119-t1x9gknd 3683 40 assay assay NN cord-010119-t1x9gknd 3683 41 . . . cord-010119-t1x9gknd 3684 1 In in IN cord-010119-t1x9gknd 3684 2 Vitro Vitro NNP cord-010119-t1x9gknd 3684 3 Quality Quality NNP cord-010119-t1x9gknd 3684 4 of of IN cord-010119-t1x9gknd 3684 5 Rejuvenated rejuvenate VBN cord-010119-t1x9gknd 3684 6 and and CC cord-010119-t1x9gknd 3684 7 Washed washed JJ cord-010119-t1x9gknd 3684 8 CPD CPD NNP cord-010119-t1x9gknd 3684 9 / / SYM cord-010119-t1x9gknd 3684 10 As-1 As-1 NNP cord-010119-t1x9gknd 3685 1 and and CC cord-010119-t1x9gknd 3685 2 CP2D CP2D NNPS cord-010119-t1x9gknd 3685 3 / / SYM cord-010119-t1x9gknd 3685 4 As-3 As-3 NNP cord-010119-t1x9gknd 3686 1 RBC RBC NNP cord-010119-t1x9gknd 3686 2 Alan Alan NNP cord-010119-t1x9gknd 3686 3 D. D. NNP cord-010119-t1x9gknd 3686 4 Gray Gray NNP cord-010119-t1x9gknd 3686 5 * * NFP cord-010119-t1x9gknd 3687 1 1 1 LS cord-010119-t1x9gknd 3687 2 , , , cord-010119-t1x9gknd 3687 3 Matt Matt NNP cord-010119-t1x9gknd 3687 4 Landrigan Landrigan NNP cord-010119-t1x9gknd 3687 5 2 2 CD cord-010119-t1x9gknd 3687 6 , , , cord-010119-t1x9gknd 3687 7 Pamela Pamela NNP cord-010119-t1x9gknd 3687 8 Whitley Whitley NNP cord-010119-t1x9gknd 3687 9 3 3 CD cord-010119-t1x9gknd 3687 10 , , , cord-010119-t1x9gknd 3687 11 Michael Michael NNP cord-010119-t1x9gknd 3687 12 Wellington Wellington NNP cord-010119-t1x9gknd 3687 13 3 3 CD cord-010119-t1x9gknd 3687 14 , , , cord-010119-t1x9gknd 3687 15 Sherrie Sherrie NNP cord-010119-t1x9gknd 3687 16 Sawyer Sawyer NNP cord-010119-t1x9gknd 3687 17 3 3 CD cord-010119-t1x9gknd 3687 18 , , , cord-010119-t1x9gknd 3687 19 Shalene Shalene NNP cord-010119-t1x9gknd 3687 20 Hanley Hanley NNP cord-010119-t1x9gknd 3687 21 3 3 CD cord-010119-t1x9gknd 3687 22 , , , cord-010119-t1x9gknd 3687 23 Emily Emily NNP cord-010119-t1x9gknd 3687 24 Rondeau Rondeau NNP cord-010119-t1x9gknd 3687 25 4 4 CD cord-010119-t1x9gknd 3687 26 , , , cord-010119-t1x9gknd 3687 27 Louise Louise NNP cord-010119-t1x9gknd 3687 28 Herschel Herschel NNP cord-010119-t1x9gknd 3687 29 4 4 CD cord-010119-t1x9gknd 3687 30 , , , cord-010119-t1x9gknd 3687 31 Neeta Neeta NNP cord-010119-t1x9gknd 3687 32 Rugg Rugg NNP cord-010119-t1x9gknd 3687 33 5 5 CD cord-010119-t1x9gknd 3687 34 , , , cord-010119-t1x9gknd 3687 35 Patricia Patricia NNP cord-010119-t1x9gknd 3687 36 A.R. A.R. NNP cord-010119-t1x9gknd 3687 37 Brunker Brunker NNP cord-010119-t1x9gknd 3687 38 3 3 CD cord-010119-t1x9gknd 3687 39 , , , cord-010119-t1x9gknd 3687 40 Shawnagay Shawnagay NNP cord-010119-t1x9gknd 3687 41 Nestheide Nestheide NNP cord-010119-t1x9gknd 3687 42 5 5 CD cord-010119-t1x9gknd 3687 43 , , , cord-010119-t1x9gknd 3687 44 Jose Jose NNP cord-010119-t1x9gknd 3687 45 Cancelas Cancelas NNP cord-010119-t1x9gknd 3687 46 - - HYPH cord-010119-t1x9gknd 3687 47 Perez Perez NNP cord-010119-t1x9gknd 3687 48 5 5 CD cord-010119-t1x9gknd 3687 49 , , , cord-010119-t1x9gknd 3687 50 Larry Larry NNP cord-010119-t1x9gknd 3687 51 Dumont Dumont NNP cord-010119-t1x9gknd 3687 52 6 6 CD cord-010119-t1x9gknd 3687 53 and and CC cord-010119-t1x9gknd 3687 54 Zbigniew Zbigniew NNP cord-010119-t1x9gknd 3687 55 M. M. NNP cord-010119-t1x9gknd 3687 56 Szczepiorkowski Szczepiorkowski NNP cord-010119-t1x9gknd 3687 57 7 7 CD cord-010119-t1x9gknd 3687 58 . . . cord-010119-t1x9gknd 3688 1 and and CC cord-010119-t1x9gknd 3688 2 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3688 3 to to IN cord-010119-t1x9gknd 3688 4 fresh fresh JJ cord-010119-t1x9gknd 3688 5 levels level NNS cord-010119-t1x9gknd 3688 6 . . . cord-010119-t1x9gknd 3689 1 The the DT cord-010119-t1x9gknd 3689 2 objective objective NN cord-010119-t1x9gknd 3689 3 was be VBD cord-010119-t1x9gknd 3689 4 to to TO cord-010119-t1x9gknd 3689 5 demonstrate demonstrate VB cord-010119-t1x9gknd 3689 6 that that IN cord-010119-t1x9gknd 3689 7 in in IN cord-010119-t1x9gknd 3689 8 vitro vitro FW cord-010119-t1x9gknd 3689 9 quality quality NN cord-010119-t1x9gknd 3689 10 measures measure NNS cord-010119-t1x9gknd 3689 11 are be VBP cord-010119-t1x9gknd 3689 12 maintained maintain VBN cord-010119-t1x9gknd 3689 13 for for IN cord-010119-t1x9gknd 3689 14 RBC RBC NNP cord-010119-t1x9gknd 3689 15 when when WRB cord-010119-t1x9gknd 3689 16 stored store VBN cord-010119-t1x9gknd 3689 17 for for IN cord-010119-t1x9gknd 3689 18 > > $ cord-010119-t1x9gknd 3689 19 24 24 CD cord-010119-t1x9gknd 3689 20 hours hour NNS cord-010119-t1x9gknd 3689 21 after after IN cord-010119-t1x9gknd 3689 22 treatment treatment NN cord-010119-t1x9gknd 3689 23 with with IN cord-010119-t1x9gknd 3689 24 an an DT cord-010119-t1x9gknd 3689 25 FDA FDA NNP cord-010119-t1x9gknd 3689 26 approved approve VBN cord-010119-t1x9gknd 3689 27 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3689 28 solution solution NN cord-010119-t1x9gknd 3689 29 . . . cord-010119-t1x9gknd 3690 1 Study Study NNP cord-010119-t1x9gknd 3690 2 Design Design NNP cord-010119-t1x9gknd 3690 3 / / SYM cord-010119-t1x9gknd 3690 4 Method method NN cord-010119-t1x9gknd 3690 5 : : : cord-010119-t1x9gknd 3691 1 Whole whole JJ cord-010119-t1x9gknd 3691 2 blood blood NN cord-010119-t1x9gknd 3691 3 ( ( -LRB- cord-010119-t1x9gknd 3691 4 530 530 CD cord-010119-t1x9gknd 3691 5 - - SYM cord-010119-t1x9gknd 3691 6 550 550 CD cord-010119-t1x9gknd 3691 7 mL ml NN cord-010119-t1x9gknd 3691 8 ) ) -RRB- cord-010119-t1x9gknd 3691 9 was be VBD cord-010119-t1x9gknd 3691 10 collected collect VBN cord-010119-t1x9gknd 3691 11 and and CC cord-010119-t1x9gknd 3691 12 processed process VBN cord-010119-t1x9gknd 3691 13 at at IN cord-010119-t1x9gknd 3691 14 3 3 CD cord-010119-t1x9gknd 3691 15 sites site NNS cord-010119-t1x9gknd 3691 16 into into IN cord-010119-t1x9gknd 3691 17 leukocyte leukocyte NN cord-010119-t1x9gknd 3691 18 - - HYPH cord-010119-t1x9gknd 3691 19 reduced reduce VBN cord-010119-t1x9gknd 3691 20 RBC RBC NNP cord-010119-t1x9gknd 3691 21 ( ( -LRB- cord-010119-t1x9gknd 3691 22 a a DT cord-010119-t1x9gknd 3691 23 total total NN cord-010119-t1x9gknd 3691 24 of of IN cord-010119-t1x9gknd 3691 25 n563 n563 NNP cord-010119-t1x9gknd 3691 26 CPD/ CPD/ NNP cord-010119-t1x9gknd 3691 27 AS-1 AS-1 NNP cord-010119-t1x9gknd 3692 1 and and CC cord-010119-t1x9gknd 3692 2 n564 n564 NN cord-010119-t1x9gknd 3693 1 CP2D CP2D NNP cord-010119-t1x9gknd 3693 2 / / SYM cord-010119-t1x9gknd 3693 3 AS-3 AS-3 NNP cord-010119-t1x9gknd 3693 4 ) ) -RRB- cord-010119-t1x9gknd 3693 5 . . . cord-010119-t1x9gknd 3693 6 50 50 CD cord-010119-t1x9gknd 3693 7 mL mL NNS cord-010119-t1x9gknd 3693 8 of of IN cord-010119-t1x9gknd 3693 9 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3693 10 solution solution NN cord-010119-t1x9gknd 3693 11 ( ( -LRB- cord-010119-t1x9gknd 3693 12 Citra Citra NNP cord-010119-t1x9gknd 3693 13 Labs Labs NNP cord-010119-t1x9gknd 3693 14 ) ) -RRB- cord-010119-t1x9gknd 3693 15 was be VBD cord-010119-t1x9gknd 3693 16 added add VBN cord-010119-t1x9gknd 3693 17 to to IN cord-010119-t1x9gknd 3693 18 each each DT cord-010119-t1x9gknd 3693 19 RBC RBC NNP cord-010119-t1x9gknd 3693 20 on on IN cord-010119-t1x9gknd 3693 21 Day Day NNP cord-010119-t1x9gknd 3693 22 35 35 CD cord-010119-t1x9gknd 3693 23 ( ( -LRB- cord-010119-t1x9gknd 3693 24 D-35 D-35 NNP cord-010119-t1x9gknd 3693 25 ) ) -RRB- cord-010119-t1x9gknd 3693 26 , , , cord-010119-t1x9gknd 3693 27 incubated incubate VBN cord-010119-t1x9gknd 3693 28 for for IN cord-010119-t1x9gknd 3693 29 60 60 CD cord-010119-t1x9gknd 3693 30 minutes minute NNS cord-010119-t1x9gknd 3693 31 with with IN cord-010119-t1x9gknd 3693 32 agitation agitation NN cord-010119-t1x9gknd 3693 33 at at IN cord-010119-t1x9gknd 3693 34 378C 378c CD cord-010119-t1x9gknd 3693 35 water water NN cord-010119-t1x9gknd 3693 36 bath bath NN cord-010119-t1x9gknd 3693 37 ( ( -LRB- cord-010119-t1x9gknd 3693 38 Helmer Helmer NNP cord-010119-t1x9gknd 3693 39 DH4 DH4 NNP cord-010119-t1x9gknd 3693 40 ) ) -RRB- cord-010119-t1x9gknd 3693 41 , , , cord-010119-t1x9gknd 3693 42 washed wash VBN cord-010119-t1x9gknd 3693 43 ( ( -LRB- cord-010119-t1x9gknd 3693 44 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 3693 45 ACP215 ACP215 NNP cord-010119-t1x9gknd 3693 46 ) ) -RRB- cord-010119-t1x9gknd 3693 47 , , , cord-010119-t1x9gknd 3693 48 and and CC cord-010119-t1x9gknd 3693 49 stored store VBN cord-010119-t1x9gknd 3693 50 in in IN cord-010119-t1x9gknd 3693 51 AS-3 AS-3 NNP cord-010119-t1x9gknd 3693 52 at at IN cord-010119-t1x9gknd 3693 53 1 1 CD cord-010119-t1x9gknd 3693 54 - - SYM cord-010119-t1x9gknd 3693 55 6 6 CD cord-010119-t1x9gknd 3693 56 oC oc NN cord-010119-t1x9gknd 3693 57 for for IN cord-010119-t1x9gknd 3693 58 7 7 CD cord-010119-t1x9gknd 3693 59 days day NNS cord-010119-t1x9gknd 3693 60 ( ( -LRB- cord-010119-t1x9gknd 3693 61 D-36 D-36 NNP cord-010119-t1x9gknd 3693 62 through through IN cord-010119-t1x9gknd 3693 63 D-42 D-42 NNP cord-010119-t1x9gknd 3693 64 ) ) -RRB- cord-010119-t1x9gknd 3693 65 . . . cord-010119-t1x9gknd 3694 1 In in IN cord-010119-t1x9gknd 3694 2 vitro vitro FW cord-010119-t1x9gknd 3694 3 recovery recovery NN cord-010119-t1x9gknd 3694 4 ( ( -LRB- cord-010119-t1x9gknd 3694 5 % % NN cord-010119-t1x9gknd 3694 6 ) ) -RRB- cord-010119-t1x9gknd 3694 7 was be VBD cord-010119-t1x9gknd 3694 8 calculated calculate VBN cord-010119-t1x9gknd 3694 9 and and CC cord-010119-t1x9gknd 3694 10 hemolysis hemolysis NN cord-010119-t1x9gknd 3694 11 , , , cord-010119-t1x9gknd 3694 12 ATP ATP NNP cord-010119-t1x9gknd 3694 13 , , , cord-010119-t1x9gknd 3694 14 and and CC cord-010119-t1x9gknd 3694 15 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3694 16 were be VBD cord-010119-t1x9gknd 3694 17 determined determine VBN cord-010119-t1x9gknd 3694 18 on on IN cord-010119-t1x9gknd 3694 19 Day day NN cord-010119-t1x9gknd 3694 20 0 0 CD cord-010119-t1x9gknd 3694 21 , , , cord-010119-t1x9gknd 3694 22 D-35 D-35 NNP cord-010119-t1x9gknd 3694 23 , , , cord-010119-t1x9gknd 3694 24 D-35 D-35 NNP cord-010119-t1x9gknd 3694 25 after after IN cord-010119-t1x9gknd 3694 26 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3694 27 and and CC cord-010119-t1x9gknd 3694 28 washing washing NN cord-010119-t1x9gknd 3694 29 ( ( -LRB- cord-010119-t1x9gknd 3694 30 postRJV postRJV NNP cord-010119-t1x9gknd 3694 31 ) ) -RRB- cord-010119-t1x9gknd 3694 32 , , , cord-010119-t1x9gknd 3694 33 D-36 D-36 NNP cord-010119-t1x9gknd 3694 34 , , , cord-010119-t1x9gknd 3694 35 D-38 D-38 NNP cord-010119-t1x9gknd 3694 36 , , , cord-010119-t1x9gknd 3694 37 D-40 D-40 NNP cord-010119-t1x9gknd 3694 38 , , , cord-010119-t1x9gknd 3694 39 and and CC cord-010119-t1x9gknd 3694 40 D-42 D-42 NNP cord-010119-t1x9gknd 3694 41 . . . cord-010119-t1x9gknd 3695 1 All all DT cord-010119-t1x9gknd 3695 2 units unit NNS cord-010119-t1x9gknd 3695 3 were be VBD cord-010119-t1x9gknd 3695 4 cultured culture VBN cord-010119-t1x9gknd 3695 5 on on IN cord-010119-t1x9gknd 3695 6 D-35 D-35 NNP cord-010119-t1x9gknd 3695 7 postRJV postrjv NN cord-010119-t1x9gknd 3695 8 and and CC cord-010119-t1x9gknd 3695 9 on on IN cord-010119-t1x9gknd 3695 10 D-42 D-42 NNP cord-010119-t1x9gknd 3695 11 , , , cord-010119-t1x9gknd 3695 12 and and CC cord-010119-t1x9gknd 3695 13 then then RB cord-010119-t1x9gknd 3695 14 concentrated concentrate VBN cord-010119-t1x9gknd 3695 15 by by IN cord-010119-t1x9gknd 3695 16 centrifugation centrifugation NN cord-010119-t1x9gknd 3695 17 on on IN cord-010119-t1x9gknd 3695 18 D-42 D-42 NNP cord-010119-t1x9gknd 3695 19 . . . cord-010119-t1x9gknd 3696 1 Results result NNS cord-010119-t1x9gknd 3696 2 / / SYM cord-010119-t1x9gknd 3696 3 Finding finding NN cord-010119-t1x9gknd 3696 4 : : : cord-010119-t1x9gknd 3696 5 In in IN cord-010119-t1x9gknd 3696 6 vitro vitro FW cord-010119-t1x9gknd 3696 7 RBC RBC NNP cord-010119-t1x9gknd 3696 8 recoveries recovery NNS cord-010119-t1x9gknd 3696 9 were be VBD cord-010119-t1x9gknd 3696 10 95.7 95.7 CD cord-010119-t1x9gknd 3696 11 % % NN cord-010119-t1x9gknd 3696 12 and and CC cord-010119-t1x9gknd 3696 13 95.5 95.5 CD cord-010119-t1x9gknd 3696 14 % % NN cord-010119-t1x9gknd 3696 15 ( ( -LRB- cord-010119-t1x9gknd 3696 16 AS-1 AS-1 NNP cord-010119-t1x9gknd 3696 17 and and CC cord-010119-t1x9gknd 3696 18 AS-3 AS-3 NNP cord-010119-t1x9gknd 3696 19 , , , cord-010119-t1x9gknd 3696 20 respectively respectively RB cord-010119-t1x9gknd 3696 21 ) ) -RRB- cord-010119-t1x9gknd 3696 22 and and CC cord-010119-t1x9gknd 3696 23 no no DT cord-010119-t1x9gknd 3696 24 bacterial bacterial JJ cord-010119-t1x9gknd 3696 25 growth growth NN cord-010119-t1x9gknd 3696 26 was be VBD cord-010119-t1x9gknd 3696 27 observed observe VBN cord-010119-t1x9gknd 3696 28 . . . cord-010119-t1x9gknd 3697 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 3697 2 on on IN cord-010119-t1x9gknd 3697 3 D-42 D-42 NNP cord-010119-t1x9gknd 3697 4 was be VBD cord-010119-t1x9gknd 3697 5 maintained maintain VBN cord-010119-t1x9gknd 3697 6 < < XX cord-010119-t1x9gknd 3697 7 1 1 CD cord-010119-t1x9gknd 3697 8 % % NN cord-010119-t1x9gknd 3697 9 in in IN cord-010119-t1x9gknd 3697 10 58/63 58/63 CD cord-010119-t1x9gknd 3697 11 ( ( -LRB- cord-010119-t1x9gknd 3697 12 92 92 CD cord-010119-t1x9gknd 3697 13 % % NN cord-010119-t1x9gknd 3697 14 ) ) -RRB- cord-010119-t1x9gknd 3698 1 AS-1 AS-1 NNP cord-010119-t1x9gknd 3698 2 units unit NNS cord-010119-t1x9gknd 3698 3 and and CC cord-010119-t1x9gknd 3698 4 63/64 63/64 CD cord-010119-t1x9gknd 3698 5 ( ( -LRB- cord-010119-t1x9gknd 3698 6 98.4 98.4 CD cord-010119-t1x9gknd 3698 7 % % NN cord-010119-t1x9gknd 3698 8 ) ) -RRB- cord-010119-t1x9gknd 3699 1 AS-3 AS-3 NNP cord-010119-t1x9gknd 3699 2 units unit NNS cord-010119-t1x9gknd 3699 3 . . . cord-010119-t1x9gknd 3700 1 All all DT cord-010119-t1x9gknd 3700 2 AS-1 AS-1 NNP cord-010119-t1x9gknd 3700 3 and and CC cord-010119-t1x9gknd 3700 4 AS-3 AS-3 NNP cord-010119-t1x9gknd 3700 5 units unit NNS cord-010119-t1x9gknd 3700 6 ( ( -LRB- cord-010119-t1x9gknd 3700 7 100 100 CD cord-010119-t1x9gknd 3700 8 % % NN cord-010119-t1x9gknd 3700 9 ) ) -RRB- cord-010119-t1x9gknd 3700 10 had have VBD cord-010119-t1x9gknd 3700 11 hemolysis hemolysis NN cord-010119-t1x9gknd 3700 12 < < XX cord-010119-t1x9gknd 3700 13 1 1 CD cord-010119-t1x9gknd 3700 14 % % NN cord-010119-t1x9gknd 3700 15 following follow VBG cord-010119-t1x9gknd 3700 16 concentration concentration NN cord-010119-t1x9gknd 3700 17 by by IN cord-010119-t1x9gknd 3700 18 centrifugation centrifugation NN cord-010119-t1x9gknd 3700 19 . . . cord-010119-t1x9gknd 3701 1 Morphology morphology NN cord-010119-t1x9gknd 3701 2 score score NN cord-010119-t1x9gknd 3701 3 was be VBD cord-010119-t1x9gknd 3701 4 reduced reduce VBN cord-010119-t1x9gknd 3701 5 to to IN cord-010119-t1x9gknd 3701 6 77 77 CD cord-010119-t1x9gknd 3701 7 % % NN cord-010119-t1x9gknd 3701 8 ( ( -LRB- cord-010119-t1x9gknd 3701 9 AS-1 AS-1 NNP cord-010119-t1x9gknd 3701 10 ) ) -RRB- cord-010119-t1x9gknd 3701 11 and and CC cord-010119-t1x9gknd 3701 12 74 74 CD cord-010119-t1x9gknd 3701 13 % % NN cord-010119-t1x9gknd 3701 14 ( ( -LRB- cord-010119-t1x9gknd 3701 15 AS-3 AS-3 NNP cord-010119-t1x9gknd 3701 16 ) ) -RRB- cord-010119-t1x9gknd 3701 17 by by IN cord-010119-t1x9gknd 3701 18 D-35 D-35 NNP cord-010119-t1x9gknd 3701 19 , , , cord-010119-t1x9gknd 3701 20 restored restore VBN cord-010119-t1x9gknd 3701 21 after after IN cord-010119-t1x9gknd 3701 22 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3701 23 ( ( -LRB- cord-010119-t1x9gknd 3701 24 91 91 CD cord-010119-t1x9gknd 3701 25 % % NN cord-010119-t1x9gknd 3701 26 , , , cord-010119-t1x9gknd 3701 27 92 92 CD cord-010119-t1x9gknd 3701 28 % % NN cord-010119-t1x9gknd 3701 29 , , , cord-010119-t1x9gknd 3701 30 respectively respectively RB cord-010119-t1x9gknd 3701 31 ) ) -RRB- cord-010119-t1x9gknd 3701 32 and and CC cord-010119-t1x9gknd 3701 33 maintained maintain VBD cord-010119-t1x9gknd 3701 34 through through IN cord-010119-t1x9gknd 3701 35 D-42 D-42 NNP cord-010119-t1x9gknd 3701 36 ( ( -LRB- cord-010119-t1x9gknd 3701 37 > > NFP cord-010119-t1x9gknd 3701 38 90 90 CD cord-010119-t1x9gknd 3701 39 % % NN cord-010119-t1x9gknd 3701 40 ) ) -RRB- cord-010119-t1x9gknd 3701 41 . . . cord-010119-t1x9gknd 3702 1 ATP ATP NNP cord-010119-t1x9gknd 3702 2 was be VBD cord-010119-t1x9gknd 3702 3 restored restore VBN cord-010119-t1x9gknd 3702 4 and and CC cord-010119-t1x9gknd 3702 5 maintained maintain VBN cord-010119-t1x9gknd 3702 6 above above IN cord-010119-t1x9gknd 3702 7 fresh fresh JJ cord-010119-t1x9gknd 3702 8 levels level NNS cord-010119-t1x9gknd 3702 9 after after IN cord-010119-t1x9gknd 3702 10 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3702 11 . . . cord-010119-t1x9gknd 3703 1 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3703 2 was be VBD cord-010119-t1x9gknd 3703 3 restored restore VBN cord-010119-t1x9gknd 3703 4 above above IN cord-010119-t1x9gknd 3703 5 fresh fresh JJ cord-010119-t1x9gknd 3703 6 levels level NNS cord-010119-t1x9gknd 3703 7 and and CC cord-010119-t1x9gknd 3703 8 was be VBD cord-010119-t1x9gknd 3703 9 maintained maintain VBN cord-010119-t1x9gknd 3703 10 ! ! . cord-010119-t1x9gknd 3704 1 80 80 CD cord-010119-t1x9gknd 3704 2 % % NN cord-010119-t1x9gknd 3704 3 of of IN cord-010119-t1x9gknd 3704 4 fresh fresh JJ cord-010119-t1x9gknd 3704 5 levels level NNS cord-010119-t1x9gknd 3704 6 through through IN cord-010119-t1x9gknd 3704 7 D-38 D-38 NNP cord-010119-t1x9gknd 3704 8 . . . cord-010119-t1x9gknd 3705 1 All all DT cord-010119-t1x9gknd 3705 2 values value NNS cord-010119-t1x9gknd 3705 3 were be VBD cord-010119-t1x9gknd 3705 4 significantly significantly RB cord-010119-t1x9gknd 3705 5 different different JJ cord-010119-t1x9gknd 3705 6 compared compare VBN cord-010119-t1x9gknd 3705 7 to to IN cord-010119-t1x9gknd 3705 8 D-35 D-35 NNP cord-010119-t1x9gknd 3705 9 except except IN cord-010119-t1x9gknd 3705 10 as as IN cord-010119-t1x9gknd 3705 11 noted note VBN cord-010119-t1x9gknd 3705 12 ( ( -LRB- cord-010119-t1x9gknd 3705 13 p<0.001 p<0.001 NNS cord-010119-t1x9gknd 3705 14 , , , cord-010119-t1x9gknd 3705 15 paired pair VBN cord-010119-t1x9gknd 3705 16 ttest ttest NNP cord-010119-t1x9gknd 3705 17 ) ) -RRB- cord-010119-t1x9gknd 3706 1 ( ( -LRB- cord-010119-t1x9gknd 3706 2 Table table NN cord-010119-t1x9gknd 3706 3 1 1 CD cord-010119-t1x9gknd 3706 4 ) ) -RRB- cord-010119-t1x9gknd 3706 5 . . . cord-010119-t1x9gknd 3707 1 Conclusion conclusion NN cord-010119-t1x9gknd 3707 2 : : : cord-010119-t1x9gknd 3708 1 Rejuvenation rejuvenation NN cord-010119-t1x9gknd 3708 2 of of IN cord-010119-t1x9gknd 3708 3 stored store VBN cord-010119-t1x9gknd 3708 4 RBC RBC NNP cord-010119-t1x9gknd 3708 5 restores restore VBZ cord-010119-t1x9gknd 3708 6 ATP ATP NNP cord-010119-t1x9gknd 3708 7 and and CC cord-010119-t1x9gknd 3708 8 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3708 9 above above IN cord-010119-t1x9gknd 3708 10 fresh fresh JJ cord-010119-t1x9gknd 3708 11 values value NNS cord-010119-t1x9gknd 3708 12 and and CC cord-010119-t1x9gknd 3708 13 morphology morphology NN cord-010119-t1x9gknd 3708 14 to to IN cord-010119-t1x9gknd 3708 15 near near IN cord-010119-t1x9gknd 3708 16 fresh fresh JJ cord-010119-t1x9gknd 3708 17 levels level NNS cord-010119-t1x9gknd 3708 18 while while IN cord-010119-t1x9gknd 3708 19 maintaining maintain VBG cord-010119-t1x9gknd 3708 20 improved improve VBN cord-010119-t1x9gknd 3708 21 in in IN cord-010119-t1x9gknd 3708 22 vitro vitro FW cord-010119-t1x9gknd 3708 23 RBC RBC NNP cord-010119-t1x9gknd 3708 24 quality quality NN cord-010119-t1x9gknd 3708 25 measures measure NNS cord-010119-t1x9gknd 3708 26 through through IN cord-010119-t1x9gknd 3708 27 D-42 D-42 NNP cord-010119-t1x9gknd 3708 28 when when WRB cord-010119-t1x9gknd 3708 29 compared compare VBN cord-010119-t1x9gknd 3708 30 to to IN cord-010119-t1x9gknd 3708 31 nonrejuvenated nonrejuvenate VBN cord-010119-t1x9gknd 3708 32 RBC RBC NNP cord-010119-t1x9gknd 3708 33 on on IN cord-010119-t1x9gknd 3708 34 D-35 D-35 NNP cord-010119-t1x9gknd 3708 35 . . . cord-010119-t1x9gknd 3709 1 This this DT cord-010119-t1x9gknd 3709 2 study study NN cord-010119-t1x9gknd 3709 3 is be VBZ cord-010119-t1x9gknd 3709 4 funded fund VBN cord-010119-t1x9gknd 3709 5 by by IN cord-010119-t1x9gknd 3709 6 Zimmer Zimmer NNP cord-010119-t1x9gknd 3709 7 Biomet Biomet NNP cord-010119-t1x9gknd 3709 8 . . . cord-010119-t1x9gknd 3710 1 Storage storage NN cord-010119-t1x9gknd 3710 2 > > XX cord-010119-t1x9gknd 3711 1 24 24 CD cord-010119-t1x9gknd 3711 2 hours hour NNS cord-010119-t1x9gknd 3711 3 is be VBZ cord-010119-t1x9gknd 3711 4 not not RB cord-010119-t1x9gknd 3711 5 FDA FDA NNP cord-010119-t1x9gknd 3711 6 approved approve VBN cord-010119-t1x9gknd 3711 7 for for IN cord-010119-t1x9gknd 3711 8 use use NN cord-010119-t1x9gknd 3711 9 at at IN cord-010119-t1x9gknd 3711 10 the the DT cord-010119-t1x9gknd 3711 11 time time NN cord-010119-t1x9gknd 3711 12 of of IN cord-010119-t1x9gknd 3711 13 this this DT cord-010119-t1x9gknd 3711 14 publication publication NN cord-010119-t1x9gknd 3711 15 . . . cord-010119-t1x9gknd 3712 1 Liposomes liposome NNS cord-010119-t1x9gknd 3712 2 and and CC cord-010119-t1x9gknd 3712 3 Rejuvenation rejuvenation NN cord-010119-t1x9gknd 3712 4 : : : cord-010119-t1x9gknd 3712 5 New New NNP cord-010119-t1x9gknd 3712 6 Approach Approach NNP cord-010119-t1x9gknd 3712 7 for for IN cord-010119-t1x9gknd 3712 8 Improving improve VBG cord-010119-t1x9gknd 3712 9 Quality Quality NNP cord-010119-t1x9gknd 3712 10 of of IN cord-010119-t1x9gknd 3712 11 Stored Stored NNP cord-010119-t1x9gknd 3712 12 Red Red NNP cord-010119-t1x9gknd 3712 13 Blood Blood NNP cord-010119-t1x9gknd 3712 14 Cells cell NNS cord-010119-t1x9gknd 3712 15 Luciana Luciana NNP cord-010119-t1x9gknd 3712 16 da da NN cord-010119-t1x9gknd 3712 17 Silveira Silveira NNP cord-010119-t1x9gknd 3713 1 Cavalcante Cavalcante NNP cord-010119-t1x9gknd 3713 2 1 1 CD cord-010119-t1x9gknd 3713 3 , , , cord-010119-t1x9gknd 3713 4 Jason Jason NNP cord-010119-t1x9gknd 3713 5 P. P. NNP cord-010119-t1x9gknd 3713 6 Acker Acker NNP cord-010119-t1x9gknd 3714 1 * * NFP cord-010119-t1x9gknd 3714 2 1,2 1,2 CD cord-010119-t1x9gknd 3714 3 and and CC cord-010119-t1x9gknd 3714 4 Jelena Jelena NNP cord-010119-t1x9gknd 3714 5 Holovati Holovati NNP cord-010119-t1x9gknd 3714 6 1 1 CD cord-010119-t1x9gknd 3714 7 . . . cord-010119-t1x9gknd 3715 1 Background Background NNP cord-010119-t1x9gknd 3715 2 / / SYM cord-010119-t1x9gknd 3715 3 Case Case NNP cord-010119-t1x9gknd 3715 4 Studies Studies NNPS cord-010119-t1x9gknd 3715 5 : : : cord-010119-t1x9gknd 3716 1 Liposomes liposome NNS cord-010119-t1x9gknd 3716 2 have have VBP cord-010119-t1x9gknd 3716 3 been be VBN cord-010119-t1x9gknd 3716 4 shown show VBN cord-010119-t1x9gknd 3716 5 to to TO cord-010119-t1x9gknd 3716 6 minimize minimize VB cord-010119-t1x9gknd 3716 7 RBC RBC NNP cord-010119-t1x9gknd 3716 8 membrane membrane NN cord-010119-t1x9gknd 3716 9 damage damage NN cord-010119-t1x9gknd 3716 10 occurring occur VBG cord-010119-t1x9gknd 3716 11 during during IN cord-010119-t1x9gknd 3716 12 42-day 42-day CD cord-010119-t1x9gknd 3716 13 hypothermic hypothermic JJ cord-010119-t1x9gknd 3716 14 storage storage NN cord-010119-t1x9gknd 3716 15 ( ( -LRB- cord-010119-t1x9gknd 3716 16 HS HS NNP cord-010119-t1x9gknd 3716 17 ) ) -RRB- cord-010119-t1x9gknd 3716 18 , , , cord-010119-t1x9gknd 3716 19 while while IN cord-010119-t1x9gknd 3716 20 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3716 21 solutions solution NNS cord-010119-t1x9gknd 3716 22 have have VBP cord-010119-t1x9gknd 3716 23 been be VBN cord-010119-t1x9gknd 3716 24 shown show VBN cord-010119-t1x9gknd 3716 25 to to TO cord-010119-t1x9gknd 3716 26 restore restore VB cord-010119-t1x9gknd 3716 27 RBC RBC NNP cord-010119-t1x9gknd 3716 28 metabolism metabolism NN cord-010119-t1x9gknd 3716 29 by by IN cord-010119-t1x9gknd 3716 30 maintaining maintain VBG cord-010119-t1x9gknd 3716 31 ATP ATP NNP cord-010119-t1x9gknd 3716 32 and and CC cord-010119-t1x9gknd 3716 33 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3716 34 levels level NNS cord-010119-t1x9gknd 3716 35 . . . cord-010119-t1x9gknd 3717 1 This this DT cord-010119-t1x9gknd 3717 2 study study NN cord-010119-t1x9gknd 3717 3 aimed aim VBD cord-010119-t1x9gknd 3717 4 to to TO cord-010119-t1x9gknd 3717 5 evaluate evaluate VB cord-010119-t1x9gknd 3717 6 the the DT cord-010119-t1x9gknd 3717 7 effect effect NN cord-010119-t1x9gknd 3717 8 of of IN cord-010119-t1x9gknd 3717 9 combining combine VBG cord-010119-t1x9gknd 3717 10 liposomes liposome NNS cord-010119-t1x9gknd 3717 11 and and CC cord-010119-t1x9gknd 3717 12 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3717 13 on on IN cord-010119-t1x9gknd 3717 14 the the DT cord-010119-t1x9gknd 3717 15 quality quality NN cord-010119-t1x9gknd 3717 16 of of IN cord-010119-t1x9gknd 3717 17 stored store VBN cord-010119-t1x9gknd 3717 18 RBCs rbc NNS cord-010119-t1x9gknd 3717 19 . . . cord-010119-t1x9gknd 3718 1 Study Study NNP cord-010119-t1x9gknd 3718 2 Design Design NNP cord-010119-t1x9gknd 3718 3 / / SYM cord-010119-t1x9gknd 3718 4 Methods method NNS cord-010119-t1x9gknd 3718 5 : : : cord-010119-t1x9gknd 3718 6 Five five CD cord-010119-t1x9gknd 3718 7 leukoreduced leukoreduced JJ cord-010119-t1x9gknd 3718 8 packed pack VBN cord-010119-t1x9gknd 3718 9 RBC RBC NNP cord-010119-t1x9gknd 3718 10 units unit NNS cord-010119-t1x9gknd 3718 11 obtained obtain VBN cord-010119-t1x9gknd 3718 12 were be VBD cord-010119-t1x9gknd 3718 13 pooled pool VBN cord-010119-t1x9gknd 3718 14 and and CC cord-010119-t1x9gknd 3718 15 split split VBN cord-010119-t1x9gknd 3718 16 . . . cord-010119-t1x9gknd 3719 1 The the DT cord-010119-t1x9gknd 3719 2 units unit NNS cord-010119-t1x9gknd 3719 3 produced produce VBN cord-010119-t1x9gknd 3719 4 were be VBD cord-010119-t1x9gknd 3719 5 segregated segregate VBN cord-010119-t1x9gknd 3719 6 into into IN cord-010119-t1x9gknd 3719 7 four four CD cord-010119-t1x9gknd 3719 8 experimental experimental JJ cord-010119-t1x9gknd 3719 9 groups group NNS cord-010119-t1x9gknd 3719 10 : : : cord-010119-t1x9gknd 3719 11 sham sham NNP cord-010119-t1x9gknd 3719 12 control control NN cord-010119-t1x9gknd 3719 13 ( ( -LRB- cord-010119-t1x9gknd 3719 14 S S NNP cord-010119-t1x9gknd 3719 15 ) ) -RRB- cord-010119-t1x9gknd 3719 16 , , , cord-010119-t1x9gknd 3719 17 liposome liposome NN cord-010119-t1x9gknd 3719 18 - - HYPH cord-010119-t1x9gknd 3719 19 treated treat VBN cord-010119-t1x9gknd 3719 20 ( ( -LRB- cord-010119-t1x9gknd 3719 21 L L NNP cord-010119-t1x9gknd 3719 22 ) ) -RRB- cord-010119-t1x9gknd 3719 23 , , , cord-010119-t1x9gknd 3719 24 rejuvesol rejuvesol NN cord-010119-t1x9gknd 3719 25 - - HYPH cord-010119-t1x9gknd 3719 26 treated treat VBN cord-010119-t1x9gknd 3719 27 ( ( -LRB- cord-010119-t1x9gknd 3719 28 R r NN cord-010119-t1x9gknd 3719 29 ) ) -RRB- cord-010119-t1x9gknd 3719 30 and and CC cord-010119-t1x9gknd 3719 31 liposome liposome NN cord-010119-t1x9gknd 3719 32 1 1 CD cord-010119-t1x9gknd 3719 33 rejuvesol rejuvesol NN cord-010119-t1x9gknd 3719 34 - - HYPH cord-010119-t1x9gknd 3719 35 treated treat VBN cord-010119-t1x9gknd 3719 36 ( ( -LRB- cord-010119-t1x9gknd 3719 37 L1R l1r NN cord-010119-t1x9gknd 3719 38 ) ) -RRB- cord-010119-t1x9gknd 3719 39 . . . cord-010119-t1x9gknd 3720 1 The the DT cord-010119-t1x9gknd 3720 2 pRBCs prbc NNS cord-010119-t1x9gknd 3720 3 were be VBD cord-010119-t1x9gknd 3720 4 incubated incubate VBN cord-010119-t1x9gknd 3720 5 for for IN cord-010119-t1x9gknd 3720 6 1 1 CD cord-010119-t1x9gknd 3720 7 h h NN cord-010119-t1x9gknd 3720 8 at at IN cord-010119-t1x9gknd 3720 9 378C 378c CD cord-010119-t1x9gknd 3720 10 with with IN cord-010119-t1x9gknd 3720 11 HEPES HEPES NNP cord-010119-t1x9gknd 3720 12 - - HYPH cord-010119-t1x9gknd 3720 13 NaCl nacl NN cord-010119-t1x9gknd 3720 14 ( ( -LRB- cord-010119-t1x9gknd 3720 15 sham sham NN cord-010119-t1x9gknd 3720 16 ) ) -RRB- cord-010119-t1x9gknd 3720 17 , , , cord-010119-t1x9gknd 3720 18 liposomes liposome NNS cord-010119-t1x9gknd 3720 19 ( ( -LRB- cord-010119-t1x9gknd 3720 20 DOPC DOPC NNP cord-010119-t1x9gknd 3720 21 : : : cord-010119-t1x9gknd 3720 22 CHOL CHOL NNP cord-010119-t1x9gknd 3720 23 , , , cord-010119-t1x9gknd 3720 24 7:3 7:3 CD cord-010119-t1x9gknd 3720 25 mol% mol% CD cord-010119-t1x9gknd 3720 26 , , , cord-010119-t1x9gknd 3720 27 2 2 CD cord-010119-t1x9gknd 3720 28 mM mm CD cord-010119-t1x9gknd 3720 29 lipid lipid NN cord-010119-t1x9gknd 3720 30 ) ) -RRB- cord-010119-t1x9gknd 3720 31 , , , cord-010119-t1x9gknd 3720 32 Rejuvesol Rejuvesol NNP cord-010119-t1x9gknd 3720 33 or or CC cord-010119-t1x9gknd 3720 34 liposomes liposome NNS cord-010119-t1x9gknd 3720 35 plus plus CC cord-010119-t1x9gknd 3720 36 Rejuvesol Rejuvesol NNP cord-010119-t1x9gknd 3720 37 . . . cord-010119-t1x9gknd 3721 1 The the DT cord-010119-t1x9gknd 3721 2 in in FW cord-010119-t1x9gknd 3721 3 vitro vitro FW cord-010119-t1x9gknd 3721 4 quality quality NN cord-010119-t1x9gknd 3721 5 was be VBD cord-010119-t1x9gknd 3721 6 accessed access VBN cord-010119-t1x9gknd 3721 7 by by IN cord-010119-t1x9gknd 3721 8 hemolysis hemolysis NN cord-010119-t1x9gknd 3721 9 , , , cord-010119-t1x9gknd 3721 10 deformability deformability NN cord-010119-t1x9gknd 3721 11 , , , cord-010119-t1x9gknd 3721 12 aggregation aggregation NN cord-010119-t1x9gknd 3721 13 , , , cord-010119-t1x9gknd 3721 14 ATP ATP NNP cord-010119-t1x9gknd 3721 15 and and CC cord-010119-t1x9gknd 3721 16 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3721 17 at at IN cord-010119-t1x9gknd 3721 18 day day NN cord-010119-t1x9gknd 3721 19 42 42 CD cord-010119-t1x9gknd 3721 20 HS HS NNP cord-010119-t1x9gknd 3721 21 . . . cord-010119-t1x9gknd 3722 1 Results result NNS cord-010119-t1x9gknd 3722 2 / / SYM cord-010119-t1x9gknd 3722 3 Findings finding NNS cord-010119-t1x9gknd 3722 4 : : : cord-010119-t1x9gknd 3723 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 3723 2 was be VBD cord-010119-t1x9gknd 3723 3 significantly significantly RB cord-010119-t1x9gknd 3723 4 decreased decrease VBN cord-010119-t1x9gknd 3723 5 in in IN cord-010119-t1x9gknd 3723 6 all all DT cord-010119-t1x9gknd 3723 7 treatments treatment NNS cord-010119-t1x9gknd 3723 8 compared compare VBN cord-010119-t1x9gknd 3723 9 to to IN cord-010119-t1x9gknd 3723 10 sham sham JJ cord-010119-t1x9gknd 3723 11 control control NN cord-010119-t1x9gknd 3723 12 ( ( -LRB- cord-010119-t1x9gknd 3723 13 0.60 0.60 CD cord-010119-t1x9gknd 3723 14 6 6 CD cord-010119-t1x9gknd 3723 15 0.06 0.06 CD cord-010119-t1x9gknd 3723 16 % % NN cord-010119-t1x9gknd 3723 17 ) ) -RRB- cord-010119-t1x9gknd 3723 18 : : : cord-010119-t1x9gknd 3723 19 L L NNP cord-010119-t1x9gknd 3723 20 ( ( -LRB- cord-010119-t1x9gknd 3723 21 0.53 0.53 CD cord-010119-t1x9gknd 3723 22 6 6 CD cord-010119-t1x9gknd 3723 23 0.01 0.01 CD cord-010119-t1x9gknd 3723 24 % % NN cord-010119-t1x9gknd 3723 25 , , , cord-010119-t1x9gknd 3723 26 p50.042 p50.042 NNP cord-010119-t1x9gknd 3723 27 ) ) -RRB- cord-010119-t1x9gknd 3723 28 , , , cord-010119-t1x9gknd 3723 29 R r NN cord-010119-t1x9gknd 3723 30 ( ( -LRB- cord-010119-t1x9gknd 3723 31 0.43 0.43 CD cord-010119-t1x9gknd 3723 32 6 6 CD cord-010119-t1x9gknd 3723 33 0.02 0.02 CD cord-010119-t1x9gknd 3723 34 % % NN cord-010119-t1x9gknd 3723 35 , , , cord-010119-t1x9gknd 3723 36 p50.004 p50.004 NNP cord-010119-t1x9gknd 3723 37 ) ) -RRB- cord-010119-t1x9gknd 3723 38 , , , cord-010119-t1x9gknd 3723 39 L1R L1R NNP cord-010119-t1x9gknd 3723 40 ( ( -LRB- cord-010119-t1x9gknd 3723 41 0.48 0.48 CD cord-010119-t1x9gknd 3723 42 6 6 CD cord-010119-t1x9gknd 3723 43 0.06 0.06 CD cord-010119-t1x9gknd 3723 44 % % NN cord-010119-t1x9gknd 3723 45 , , , cord-010119-t1x9gknd 3723 46 p50.020 p50.020 NNP cord-010119-t1x9gknd 3723 47 ) ) -RRB- cord-010119-t1x9gknd 3723 48 . . . cord-010119-t1x9gknd 3724 1 Ektacytometry ektacytometry NN cord-010119-t1x9gknd 3724 2 analysis analysis NN cord-010119-t1x9gknd 3724 3 showed show VBD cord-010119-t1x9gknd 3724 4 an an DT cord-010119-t1x9gknd 3724 5 increase increase NN cord-010119-t1x9gknd 3724 6 in in IN cord-010119-t1x9gknd 3724 7 maximum maximum JJ cord-010119-t1x9gknd 3724 8 elongation elongation NN cord-010119-t1x9gknd 3724 9 ( ( -LRB- cord-010119-t1x9gknd 3724 10 EI EI NNP cord-010119-t1x9gknd 3724 11 max max NNP cord-010119-t1x9gknd 3724 12 ) ) -RRB- cord-010119-t1x9gknd 3724 13 in in IN cord-010119-t1x9gknd 3724 14 R r NN cord-010119-t1x9gknd 3724 15 ( ( -LRB- cord-010119-t1x9gknd 3724 16 0.55 0.55 CD cord-010119-t1x9gknd 3724 17 6 6 CD cord-010119-t1x9gknd 3724 18 0.01 0.01 CD cord-010119-t1x9gknd 3724 19 , , , cord-010119-t1x9gknd 3724 20 p50.010 p50.010 NNP cord-010119-t1x9gknd 3724 21 ) ) -RRB- cord-010119-t1x9gknd 3724 22 and and CC cord-010119-t1x9gknd 3724 23 L1R l1r NN cord-010119-t1x9gknd 3724 24 ( ( -LRB- cord-010119-t1x9gknd 3724 25 0.55 0.55 CD cord-010119-t1x9gknd 3724 26 6 6 CD cord-010119-t1x9gknd 3724 27 0.01 0.01 CD cord-010119-t1x9gknd 3724 28 , , , cord-010119-t1x9gknd 3724 29 p50.010 p50.010 NN cord-010119-t1x9gknd 3724 30 ) ) -RRB- cord-010119-t1x9gknd 3724 31 treatments treatment NNS cord-010119-t1x9gknd 3724 32 compared compare VBN cord-010119-t1x9gknd 3724 33 to to IN cord-010119-t1x9gknd 3724 34 S S NNP cord-010119-t1x9gknd 3724 35 ( ( -LRB- cord-010119-t1x9gknd 3724 36 0.53 0.53 CD cord-010119-t1x9gknd 3724 37 6 6 CD cord-010119-t1x9gknd 3724 38 0.01 0.01 CD cord-010119-t1x9gknd 3724 39 ) ) -RRB- cord-010119-t1x9gknd 3724 40 but but CC cord-010119-t1x9gknd 3724 41 not not RB cord-010119-t1x9gknd 3724 42 L L NNP cord-010119-t1x9gknd 3724 43 ( ( -LRB- cord-010119-t1x9gknd 3724 44 0.53 0.53 CD cord-010119-t1x9gknd 3724 45 6 6 CD cord-010119-t1x9gknd 3724 46 0.01 0.01 CD cord-010119-t1x9gknd 3724 47 , , , cord-010119-t1x9gknd 3724 48 p50.936 p50.936 NNP cord-010119-t1x9gknd 3724 49 ) ) -RRB- cord-010119-t1x9gknd 3724 50 . . . cord-010119-t1x9gknd 3725 1 RBC RBC NNP cord-010119-t1x9gknd 3725 2 rigidity rigidity NN cord-010119-t1x9gknd 3725 3 ( ( -LRB- cord-010119-t1x9gknd 3725 4 KEI KEI NNP cord-010119-t1x9gknd 3725 5 ) ) -RRB- cord-010119-t1x9gknd 3725 6 increased increase VBD cord-010119-t1x9gknd 3725 7 in in IN cord-010119-t1x9gknd 3725 8 all all DT cord-010119-t1x9gknd 3725 9 treatments treatment NNS cord-010119-t1x9gknd 3725 10 compared compare VBN cord-010119-t1x9gknd 3725 11 to to IN cord-010119-t1x9gknd 3725 12 sham sham NN cord-010119-t1x9gknd 3725 13 ( ( -LRB- cord-010119-t1x9gknd 3725 14 1.19 1.19 CD cord-010119-t1x9gknd 3725 15 6 6 CD cord-010119-t1x9gknd 3725 16 0.07 0.07 CD cord-010119-t1x9gknd 3725 17 ) ) -RRB- cord-010119-t1x9gknd 3725 18 : : : cord-010119-t1x9gknd 3725 19 L L NNP cord-010119-t1x9gknd 3725 20 ( ( -LRB- cord-010119-t1x9gknd 3725 21 1.28 1.28 CD cord-010119-t1x9gknd 3725 22 6 6 CD cord-010119-t1x9gknd 3725 23 0.06 0.06 CD cord-010119-t1x9gknd 3725 24 , , , cord-010119-t1x9gknd 3725 25 p50.025 p50.025 NNP cord-010119-t1x9gknd 3725 26 ) ) -RRB- cord-010119-t1x9gknd 3725 27 , , , cord-010119-t1x9gknd 3725 28 R r NN cord-010119-t1x9gknd 3725 29 ( ( -LRB- cord-010119-t1x9gknd 3725 30 1.44 1.44 CD cord-010119-t1x9gknd 3725 31 6 6 CD cord-010119-t1x9gknd 3725 32 0.17 0.17 CD cord-010119-t1x9gknd 3725 33 , , , cord-010119-t1x9gknd 3725 34 p50.010 p50.010 NNP cord-010119-t1x9gknd 3725 35 ) ) -RRB- cord-010119-t1x9gknd 3725 36 and and CC cord-010119-t1x9gknd 3725 37 R1L R1L NNP cord-010119-t1x9gknd 3725 38 ( ( -LRB- cord-010119-t1x9gknd 3725 39 1.44 1.44 CD cord-010119-t1x9gknd 3725 40 6 6 CD cord-010119-t1x9gknd 3725 41 0.06 0.06 CD cord-010119-t1x9gknd 3725 42 , , , cord-010119-t1x9gknd 3725 43 p50.004 p50.004 NN cord-010119-t1x9gknd 3725 44 ) ) -RRB- cord-010119-t1x9gknd 3725 45 . . . cord-010119-t1x9gknd 3726 1 Aggregation aggregation NN cord-010119-t1x9gknd 3726 2 amplitude amplitude NN cord-010119-t1x9gknd 3726 3 was be VBD cord-010119-t1x9gknd 3726 4 significantly significantly RB cord-010119-t1x9gknd 3726 5 increased increase VBN cord-010119-t1x9gknd 3726 6 by by IN cord-010119-t1x9gknd 3726 7 R r NN cord-010119-t1x9gknd 3726 8 treatment treatment NN cord-010119-t1x9gknd 3726 9 only only RB cord-010119-t1x9gknd 3726 10 ( ( -LRB- cord-010119-t1x9gknd 3726 11 24.07 24.07 CD cord-010119-t1x9gknd 3726 12 6 6 CD cord-010119-t1x9gknd 3726 13 1.67 1.67 CD cord-010119-t1x9gknd 3726 14 au au NNP cord-010119-t1x9gknd 3726 15 vs. vs. NNP cord-010119-t1x9gknd 3726 16 19.12 19.12 CD cord-010119-t1x9gknd 3726 17 6 6 CD cord-010119-t1x9gknd 3726 18 1.38 1.38 CD cord-010119-t1x9gknd 3726 19 au au NNS cord-010119-t1x9gknd 3726 20 , , , cord-010119-t1x9gknd 3726 21 p50.004 p50.004 NNP cord-010119-t1x9gknd 3726 22 ) ) -RRB- cord-010119-t1x9gknd 3726 23 . . . cord-010119-t1x9gknd 3727 1 ATP ATP NNP cord-010119-t1x9gknd 3727 2 levels level NNS cord-010119-t1x9gknd 3727 3 were be VBD cord-010119-t1x9gknd 3727 4 significantly significantly RB cord-010119-t1x9gknd 3727 5 higher high JJR cord-010119-t1x9gknd 3727 6 in in IN cord-010119-t1x9gknd 3727 7 all all DT cord-010119-t1x9gknd 3727 8 treatments treatment NNS cord-010119-t1x9gknd 3727 9 compared compare VBN cord-010119-t1x9gknd 3727 10 to to IN cord-010119-t1x9gknd 3727 11 sham sham JJ cord-010119-t1x9gknd 3727 12 ( ( -LRB- cord-010119-t1x9gknd 3727 13 1.64 1.64 CD cord-010119-t1x9gknd 3727 14 6 6 CD cord-010119-t1x9gknd 3727 15 0.14 0.14 CD cord-010119-t1x9gknd 3727 16 mmol mmol NN cord-010119-t1x9gknd 3727 17 / / SYM cord-010119-t1x9gknd 3727 18 g g NNP cord-010119-t1x9gknd 3727 19 Hb Hb NNP cord-010119-t1x9gknd 3727 20 ) ) -RRB- cord-010119-t1x9gknd 3727 21 : : : cord-010119-t1x9gknd 3727 22 L L NNP cord-010119-t1x9gknd 3727 23 ( ( -LRB- cord-010119-t1x9gknd 3727 24 2.00 2.00 CD cord-010119-t1x9gknd 3727 25 6 6 CD cord-010119-t1x9gknd 3727 26 0.21 0.21 CD cord-010119-t1x9gknd 3727 27 mmol mmol NN cord-010119-t1x9gknd 3727 28 / / SYM cord-010119-t1x9gknd 3727 29 g g NNP cord-010119-t1x9gknd 3727 30 Hb Hb NNP cord-010119-t1x9gknd 3727 31 , , , cord-010119-t1x9gknd 3727 32 p50.010 p50.010 NNP cord-010119-t1x9gknd 3727 33 ) ) -RRB- cord-010119-t1x9gknd 3727 34 , , , cord-010119-t1x9gknd 3727 35 R r NN cord-010119-t1x9gknd 3727 36 ( ( -LRB- cord-010119-t1x9gknd 3727 37 4.70 4.70 CD cord-010119-t1x9gknd 3727 38 6 6 CD cord-010119-t1x9gknd 3727 39 1.20 1.20 CD cord-010119-t1x9gknd 3727 40 mmol mmol JJ cord-010119-t1x9gknd 3727 41 / / SYM cord-010119-t1x9gknd 3727 42 g g NNP cord-010119-t1x9gknd 3727 43 Hb Hb NNP cord-010119-t1x9gknd 3727 44 , , , cord-010119-t1x9gknd 3727 45 p50.004 p50.004 NNP cord-010119-t1x9gknd 3727 46 ) ) -RRB- cord-010119-t1x9gknd 3727 47 , , , cord-010119-t1x9gknd 3727 48 L1R L1R NNP cord-010119-t1x9gknd 3727 49 ( ( -LRB- cord-010119-t1x9gknd 3727 50 5.00 5.00 CD cord-010119-t1x9gknd 3727 51 6 6 CD cord-010119-t1x9gknd 3727 52 1.56 1.56 CD cord-010119-t1x9gknd 3727 53 mmol mmol NN cord-010119-t1x9gknd 3727 54 / / SYM cord-010119-t1x9gknd 3727 55 g g NNP cord-010119-t1x9gknd 3727 56 Hb Hb NNP cord-010119-t1x9gknd 3727 57 , , , cord-010119-t1x9gknd 3727 58 p50.004 p50.004 NN cord-010119-t1x9gknd 3727 59 ) ) -RRB- cord-010119-t1x9gknd 3727 60 . . . cord-010119-t1x9gknd 3728 1 The the DT cord-010119-t1x9gknd 3728 2 levels level NNS cord-010119-t1x9gknd 3728 3 of of IN cord-010119-t1x9gknd 3728 4 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3728 5 were be VBD cord-010119-t1x9gknd 3728 6 no no RB cord-010119-t1x9gknd 3728 7 longer long RBR cord-010119-t1x9gknd 3728 8 detectable detectable JJ cord-010119-t1x9gknd 3728 9 in in IN cord-010119-t1x9gknd 3728 10 S S NNP cord-010119-t1x9gknd 3728 11 and and CC cord-010119-t1x9gknd 3728 12 L L NNP cord-010119-t1x9gknd 3728 13 treatments treatment NNS cord-010119-t1x9gknd 3728 14 at at IN cord-010119-t1x9gknd 3728 15 day day NN cord-010119-t1x9gknd 3728 16 42 42 CD cord-010119-t1x9gknd 3728 17 . . . cord-010119-t1x9gknd 3729 1 The the DT cord-010119-t1x9gknd 3729 2 combined combined JJ cord-010119-t1x9gknd 3729 3 treatment treatment NN cord-010119-t1x9gknd 3729 4 was be VBD cord-010119-t1x9gknd 3729 5 comparable comparable JJ cord-010119-t1x9gknd 3729 6 to to IN cord-010119-t1x9gknd 3729 7 R r NN cord-010119-t1x9gknd 3729 8 ( ( -LRB- cord-010119-t1x9gknd 3729 9 2.38 2.38 CD cord-010119-t1x9gknd 3729 10 6 6 CD cord-010119-t1x9gknd 3729 11 3.26 3.26 CD cord-010119-t1x9gknd 3729 12 mmol mmol NN cord-010119-t1x9gknd 3729 13 / / SYM cord-010119-t1x9gknd 3729 14 g g NNP cord-010119-t1x9gknd 3729 15 Hb Hb NNP cord-010119-t1x9gknd 3729 16 vs. vs. NN cord-010119-t1x9gknd 3729 17 2.62 2.62 CD cord-010119-t1x9gknd 3729 18 6 6 CD cord-010119-t1x9gknd 3729 19 2.20 2.20 CD cord-010119-t1x9gknd 3729 20 mmol mmol JJ cord-010119-t1x9gknd 3729 21 / / SYM cord-010119-t1x9gknd 3729 22 g g NNP cord-010119-t1x9gknd 3729 23 Hb Hb NNP cord-010119-t1x9gknd 3729 24 , , , cord-010119-t1x9gknd 3729 25 p50.868 p50.868 NNP cord-010119-t1x9gknd 3729 26 ) ) -RRB- cord-010119-t1x9gknd 3729 27 . . . cord-010119-t1x9gknd 3730 1 Conclusion conclusion NN cord-010119-t1x9gknd 3730 2 : : : cord-010119-t1x9gknd 3730 3 Both both DT cord-010119-t1x9gknd 3730 4 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3730 5 and and CC cord-010119-t1x9gknd 3730 6 liposome liposome NN cord-010119-t1x9gknd 3730 7 treatments treatment NNS cord-010119-t1x9gknd 3730 8 improved improve VBD cord-010119-t1x9gknd 3730 9 the the DT cord-010119-t1x9gknd 3730 10 quality quality NN cord-010119-t1x9gknd 3730 11 of of IN cord-010119-t1x9gknd 3730 12 stored store VBN cord-010119-t1x9gknd 3730 13 RBCs rbc NNS cord-010119-t1x9gknd 3730 14 compared compare VBN cord-010119-t1x9gknd 3730 15 to to IN cord-010119-t1x9gknd 3730 16 sham sham JJ cord-010119-t1x9gknd 3730 17 control control NN cord-010119-t1x9gknd 3730 18 . . . cord-010119-t1x9gknd 3731 1 The the DT cord-010119-t1x9gknd 3731 2 combined combine VBN cord-010119-t1x9gknd 3731 3 treatment treatment NN cord-010119-t1x9gknd 3731 4 ( ( -LRB- cord-010119-t1x9gknd 3731 5 L1R l1r NN cord-010119-t1x9gknd 3731 6 ) ) -RRB- cord-010119-t1x9gknd 3731 7 did do VBD cord-010119-t1x9gknd 3731 8 not not RB cord-010119-t1x9gknd 3731 9 have have VB cord-010119-t1x9gknd 3731 10 a a DT cord-010119-t1x9gknd 3731 11 greater great JJR cord-010119-t1x9gknd 3731 12 impact impact NN cord-010119-t1x9gknd 3731 13 in in IN cord-010119-t1x9gknd 3731 14 improving improve VBG cord-010119-t1x9gknd 3731 15 in in IN cord-010119-t1x9gknd 3731 16 vitro vitro FW cord-010119-t1x9gknd 3731 17 quality quality NN cord-010119-t1x9gknd 3731 18 of of IN cord-010119-t1x9gknd 3731 19 stored store VBN cord-010119-t1x9gknd 3731 20 RBCs rbc NNS cord-010119-t1x9gknd 3731 21 compared compare VBN cord-010119-t1x9gknd 3731 22 to to IN cord-010119-t1x9gknd 3731 23 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3731 24 alone alone RB cord-010119-t1x9gknd 3731 25 . . . cord-010119-t1x9gknd 3732 1 Step step VB cord-010119-t1x9gknd 3732 2 Toward toward IN cord-010119-t1x9gknd 3732 3 a a DT cord-010119-t1x9gknd 3732 4 Unique unique JJ cord-010119-t1x9gknd 3732 5 and and CC cord-010119-t1x9gknd 3732 6 Adaptable adaptable JJ cord-010119-t1x9gknd 3732 7 Thermoregulation Thermoregulation NNP cord-010119-t1x9gknd 3732 8 System System NNP cord-010119-t1x9gknd 3732 9 Lucie Lucie NNP cord-010119-t1x9gknd 3732 10 Boyer Boyer NNP cord-010119-t1x9gknd 3732 11 1 1 CD cord-010119-t1x9gknd 3732 12 , , , cord-010119-t1x9gknd 3732 13 Eric Eric NNP cord-010119-t1x9gknd 3732 14 Ducas Ducas NNP cord-010119-t1x9gknd 3732 15 1 1 CD cord-010119-t1x9gknd 3732 16 , , , cord-010119-t1x9gknd 3732 17 Patricia Patricia NNP cord-010119-t1x9gknd 3732 18 Landry Landry NNP cord-010119-t1x9gknd 3732 19 1 1 CD cord-010119-t1x9gknd 3732 20 , , , cord-010119-t1x9gknd 3732 21 Nathalie Nathalie NNP cord-010119-t1x9gknd 3732 22 Dussault Dussault NNP cord-010119-t1x9gknd 3732 23 1 1 CD cord-010119-t1x9gknd 3732 24 , , , cord-010119-t1x9gknd 3732 25 Jacques Jacques NNP cord-010119-t1x9gknd 3732 26 Bernier Bernier NNP cord-010119-t1x9gknd 3732 27 1 1 CD cord-010119-t1x9gknd 3732 28 , , , cord-010119-t1x9gknd 3732 29 Danny Danny NNP cord-010119-t1x9gknd 3732 30 Brouard Brouard NNP cord-010119-t1x9gknd 3732 31 * * NFP cord-010119-t1x9gknd 3732 32 1 1 CD cord-010119-t1x9gknd 3732 33 and and CC cord-010119-t1x9gknd 3732 34 Anne Anne NNP cord-010119-t1x9gknd 3732 35 Maltais Maltais NNP cord-010119-t1x9gknd 3732 36 2 2 CD cord-010119-t1x9gknd 3732 37 . . . cord-010119-t1x9gknd 3733 1 1 1 LS cord-010119-t1x9gknd 3733 2 H H NNP cord-010119-t1x9gknd 3733 3 ema ema NNP cord-010119-t1x9gknd 3733 4 - - HYPH cord-010119-t1x9gknd 3733 5 Qu Qu NNP cord-010119-t1x9gknd 3734 1 ebec ebec NNP cord-010119-t1x9gknd 3734 2 , , , cord-010119-t1x9gknd 3734 3 2 2 CD cord-010119-t1x9gknd 3734 4 Institut Institut NNP cord-010119-t1x9gknd 3734 5 de de NNP cord-010119-t1x9gknd 3734 6 technologie technologie NNP cord-010119-t1x9gknd 3734 7 des des FW cord-010119-t1x9gknd 3734 8 emballages emballages FW cord-010119-t1x9gknd 3734 9 et et FW cord-010119-t1x9gknd 3734 10 du du FW cord-010119-t1x9gknd 3734 11 g g NNP cord-010119-t1x9gknd 3734 12 enie enie NN cord-010119-t1x9gknd 3734 13 alimentaire alimentaire NNP cord-010119-t1x9gknd 3734 14 Background Background NNP cord-010119-t1x9gknd 3734 15 / / SYM cord-010119-t1x9gknd 3734 16 Case Case NNP cord-010119-t1x9gknd 3734 17 Studies Studies NNPS cord-010119-t1x9gknd 3734 18 : : : cord-010119-t1x9gknd 3735 1 H H NNP cord-010119-t1x9gknd 3735 2 ema ema NNP cord-010119-t1x9gknd 3735 3 - - HYPH cord-010119-t1x9gknd 3735 4 Quebec Quebec NNP cord-010119-t1x9gknd 3735 5 ( ( -LRB- cord-010119-t1x9gknd 3735 6 HQ HQ NNP cord-010119-t1x9gknd 3735 7 ) ) -RRB- cord-010119-t1x9gknd 3735 8 is be VBZ cord-010119-t1x9gknd 3735 9 facing face VBG cord-010119-t1x9gknd 3735 10 major major JJ cord-010119-t1x9gknd 3735 11 logistic logistic JJ cord-010119-t1x9gknd 3735 12 challenges challenge NNS cord-010119-t1x9gknd 3735 13 in in IN cord-010119-t1x9gknd 3735 14 the the DT cord-010119-t1x9gknd 3735 15 transportation transportation NN cord-010119-t1x9gknd 3735 16 and and CC cord-010119-t1x9gknd 3735 17 distribution distribution NN cord-010119-t1x9gknd 3735 18 of of IN cord-010119-t1x9gknd 3735 19 blood blood NN cord-010119-t1x9gknd 3735 20 components component NNS cord-010119-t1x9gknd 3735 21 over over IN cord-010119-t1x9gknd 3735 22 a a DT cord-010119-t1x9gknd 3735 23 large large JJ cord-010119-t1x9gknd 3735 24 geographic geographic JJ cord-010119-t1x9gknd 3735 25 area area NN cord-010119-t1x9gknd 3735 26 . . . cord-010119-t1x9gknd 3736 1 In in IN cord-010119-t1x9gknd 3736 2 collaboration collaboration NN cord-010119-t1x9gknd 3736 3 with with IN cord-010119-t1x9gknd 3736 4 the the DT cord-010119-t1x9gknd 3736 5 Institut Institut NNP cord-010119-t1x9gknd 3736 6 de de NNP cord-010119-t1x9gknd 3736 7 technologie technologie NNP cord-010119-t1x9gknd 3736 8 des des FW cord-010119-t1x9gknd 3736 9 emballages emballages FW cord-010119-t1x9gknd 3736 10 et et NNP cord-010119-t1x9gknd 3736 11 du du NNP cord-010119-t1x9gknd 3736 12 genie genie NNP cord-010119-t1x9gknd 3736 13 alimentaire alimentaire NNP cord-010119-t1x9gknd 3736 14 , , , cord-010119-t1x9gknd 3736 15 our -PRON- PRP$ cord-010119-t1x9gknd 3736 16 applied applied JJ cord-010119-t1x9gknd 3736 17 research research NN cord-010119-t1x9gknd 3736 18 group group NN cord-010119-t1x9gknd 3736 19 is be VBZ cord-010119-t1x9gknd 3736 20 working work VBG cord-010119-t1x9gknd 3736 21 on on IN cord-010119-t1x9gknd 3736 22 the the DT cord-010119-t1x9gknd 3736 23 development development NN cord-010119-t1x9gknd 3736 24 and and CC cord-010119-t1x9gknd 3736 25 optimization optimization NN cord-010119-t1x9gknd 3736 26 of of IN cord-010119-t1x9gknd 3736 27 a a DT cord-010119-t1x9gknd 3736 28 transport transport NN cord-010119-t1x9gknd 3736 29 packaging packaging NN cord-010119-t1x9gknd 3736 30 for for IN cord-010119-t1x9gknd 3736 31 the the DT cord-010119-t1x9gknd 3736 32 500-mL 500-ml CD cord-010119-t1x9gknd 3736 33 whole whole JJ cord-010119-t1x9gknd 3736 34 blood blood NN cord-010119-t1x9gknd 3736 35 Leukotrap Leukotrap NNP cord-010119-t1x9gknd 3736 36 RC RC NNP cord-010119-t1x9gknd 3736 37 System System NNP cord-010119-t1x9gknd 3736 38 ( ( -LRB- cord-010119-t1x9gknd 3736 39 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 3736 40 Corp. Corp. NNP cord-010119-t1x9gknd 3736 41 ) ) -RRB- cord-010119-t1x9gknd 3736 42 . . . cord-010119-t1x9gknd 3737 1 The the DT cord-010119-t1x9gknd 3737 2 objective objective NN cord-010119-t1x9gknd 3737 3 is be VBZ cord-010119-t1x9gknd 3737 4 to to TO cord-010119-t1x9gknd 3737 5 design design VB cord-010119-t1x9gknd 3737 6 a a DT cord-010119-t1x9gknd 3737 7 packaging packaging NN cord-010119-t1x9gknd 3737 8 system system NN cord-010119-t1x9gknd 3737 9 for for IN cord-010119-t1x9gknd 3737 10 the the DT cord-010119-t1x9gknd 3737 11 rapid rapid JJ cord-010119-t1x9gknd 3737 12 cooling cooling NN cord-010119-t1x9gknd 3737 13 ( ( -LRB- cord-010119-t1x9gknd 3737 14 T T NNP cord-010119-t1x9gknd 3737 15 < < XX cord-010119-t1x9gknd 3737 16 108C 108c CD cord-010119-t1x9gknd 3737 17 ) ) -RRB- cord-010119-t1x9gknd 3737 18 of of IN cord-010119-t1x9gknd 3737 19 one one CD cord-010119-t1x9gknd 3737 20 to to TO cord-010119-t1x9gknd 3737 21 six six CD cord-010119-t1x9gknd 3737 22 500-mL 500-ml CD cord-010119-t1x9gknd 3737 23 whole whole JJ cord-010119-t1x9gknd 3737 24 blood blood NN cord-010119-t1x9gknd 3737 25 units unit NNS cord-010119-t1x9gknd 3737 26 ( ( -LRB- cord-010119-t1x9gknd 3737 27 WBU WBU NNP cord-010119-t1x9gknd 3737 28 ) ) -RRB- cord-010119-t1x9gknd 3737 29 within within IN cord-010119-t1x9gknd 3737 30 8h 8h CD cord-010119-t1x9gknd 3737 31 from from IN cord-010119-t1x9gknd 3737 32 collection collection NN cord-010119-t1x9gknd 3737 33 . . . cord-010119-t1x9gknd 3738 1 Moreover moreover RB cord-010119-t1x9gknd 3738 2 , , , cord-010119-t1x9gknd 3738 3 the the DT cord-010119-t1x9gknd 3738 4 insulating insulate VBG cord-010119-t1x9gknd 3738 5 and and CC cord-010119-t1x9gknd 3738 6 thermoregulation thermoregulation NN cord-010119-t1x9gknd 3738 7 system system NN cord-010119-t1x9gknd 3738 8 must must MD cord-010119-t1x9gknd 3738 9 maintain maintain VB cord-010119-t1x9gknd 3738 10 the the DT cord-010119-t1x9gknd 3738 11 internal internal JJ cord-010119-t1x9gknd 3738 12 temperature temperature NN cord-010119-t1x9gknd 3738 13 of of IN cord-010119-t1x9gknd 3738 14 WBU WBU NNP cord-010119-t1x9gknd 3738 15 between between IN cord-010119-t1x9gknd 3738 16 18C 18C NNP cord-010119-t1x9gknd 3738 17 and and CC cord-010119-t1x9gknd 3738 18 108C 108c CD cord-010119-t1x9gknd 3738 19 for for IN cord-010119-t1x9gknd 3738 20 24h 24h NNS cord-010119-t1x9gknd 3738 21 under under IN cord-010119-t1x9gknd 3738 22 extreme extreme JJ cord-010119-t1x9gknd 3738 23 external external JJ cord-010119-t1x9gknd 3738 24 conditions condition NNS cord-010119-t1x9gknd 3738 25 ( ( -LRB- cord-010119-t1x9gknd 3738 26 -308C -308C VBN cord-010119-t1x9gknd 3738 27 to to IN cord-010119-t1x9gknd 3738 28 408C 408c CD cord-010119-t1x9gknd 3738 29 ) ) -RRB- cord-010119-t1x9gknd 3738 30 , , , cord-010119-t1x9gknd 3738 31 including include VBG cord-010119-t1x9gknd 3738 32 the the DT cord-010119-t1x9gknd 3738 33 initial initial JJ cord-010119-t1x9gknd 3738 34 blood blood NN cord-010119-t1x9gknd 3738 35 cooling cooling NN cord-010119-t1x9gknd 3738 36 period period NN cord-010119-t1x9gknd 3738 37 . . . cord-010119-t1x9gknd 3739 1 Study Study NNP cord-010119-t1x9gknd 3739 2 Design Design NNP cord-010119-t1x9gknd 3739 3 / / SYM cord-010119-t1x9gknd 3739 4 Method method NN cord-010119-t1x9gknd 3739 5 : : : cord-010119-t1x9gknd 3740 1 The the DT cord-010119-t1x9gknd 3740 2 proposed propose VBN cord-010119-t1x9gknd 3740 3 packaging packaging NN cord-010119-t1x9gknd 3740 4 design design NN cord-010119-t1x9gknd 3740 5 is be VBZ cord-010119-t1x9gknd 3740 6 based base VBN cord-010119-t1x9gknd 3740 7 on on IN cord-010119-t1x9gknd 3740 8 an an DT cord-010119-t1x9gknd 3740 9 external external JJ cord-010119-t1x9gknd 3740 10 Coroplast Coroplast NNP cord-010119-t1x9gknd 3740 11 box box NN cord-010119-t1x9gknd 3740 12 containing contain VBG cord-010119-t1x9gknd 3740 13 six six CD cord-010119-t1x9gknd 3740 14 Vacuum Vacuum NNP cord-010119-t1x9gknd 3740 15 Insulated insulated JJ cord-010119-t1x9gknd 3740 16 Panels Panels NNPS cord-010119-t1x9gknd 3740 17 ( ( -LRB- cord-010119-t1x9gknd 3740 18 VIP VIP NNP cord-010119-t1x9gknd 3740 19 ) ) -RRB- cord-010119-t1x9gknd 3740 20 for for IN cord-010119-t1x9gknd 3740 21 increased increase VBN cord-010119-t1x9gknd 3740 22 insulating insulate VBG cord-010119-t1x9gknd 3740 23 efficiency efficiency NN cord-010119-t1x9gknd 3740 24 . . . cord-010119-t1x9gknd 3741 1 Preservation preservation NN cord-010119-t1x9gknd 3741 2 of of IN cord-010119-t1x9gknd 3741 3 the the DT cord-010119-t1x9gknd 3741 4 initial initial JJ cord-010119-t1x9gknd 3741 5 cooling cool VBG cord-010119-t1x9gknd 3741 6 period period NN cord-010119-t1x9gknd 3741 7 and and CC cord-010119-t1x9gknd 3741 8 extended extended JJ cord-010119-t1x9gknd 3741 9 thermoregulation thermoregulation NN cord-010119-t1x9gknd 3741 10 properties property NNS cord-010119-t1x9gknd 3741 11 were be VBD cord-010119-t1x9gknd 3741 12 ensured ensure VBN cord-010119-t1x9gknd 3741 13 by by IN cord-010119-t1x9gknd 3741 14 an an DT cord-010119-t1x9gknd 3741 15 assembly assembly NN cord-010119-t1x9gknd 3741 16 of of IN cord-010119-t1x9gknd 3741 17 preconditioned preconditioned JJ cord-010119-t1x9gknd 3741 18 58C 58C . cord-010119-t1x9gknd 3741 19 Phase Phase NNP cord-010119-t1x9gknd 3741 20 Change change NN cord-010119-t1x9gknd 3741 21 Material Material NNP cord-010119-t1x9gknd 3741 22 ( ( -LRB- cord-010119-t1x9gknd 3741 23 PCM PCM NNP cord-010119-t1x9gknd 3741 24 ) ) -RRB- cord-010119-t1x9gknd 3741 25 . . . cord-010119-t1x9gknd 3742 1 The the DT cord-010119-t1x9gknd 3742 2 number number NN cord-010119-t1x9gknd 3742 3 of of IN cord-010119-t1x9gknd 3742 4 PCM pcm NN cord-010119-t1x9gknd 3742 5 , , , cord-010119-t1x9gknd 3742 6 their -PRON- PRP$ cord-010119-t1x9gknd 3742 7 position position NN cord-010119-t1x9gknd 3742 8 and and CC cord-010119-t1x9gknd 3742 9 conditioning conditioning NN cord-010119-t1x9gknd 3742 10 were be VBD cord-010119-t1x9gknd 3742 11 optimized optimize VBN cord-010119-t1x9gknd 3742 12 and and CC cord-010119-t1x9gknd 3742 13 tested test VBN cord-010119-t1x9gknd 3742 14 in in IN cord-010119-t1x9gknd 3742 15 order order NN cord-010119-t1x9gknd 3742 16 to to TO cord-010119-t1x9gknd 3742 17 meet meet VB cord-010119-t1x9gknd 3742 18 the the DT cord-010119-t1x9gknd 3742 19 expected expect VBN cord-010119-t1x9gknd 3742 20 performance performance NN cord-010119-t1x9gknd 3742 21 criteria criterion NNS cord-010119-t1x9gknd 3742 22 . . . cord-010119-t1x9gknd 3743 1 Preconditioned preconditioned JJ cord-010119-t1x9gknd 3743 2 PCM pcm NN cord-010119-t1x9gknd 3743 3 were be VBD cord-010119-t1x9gknd 3743 4 stored store VBN cord-010119-t1x9gknd 3743 5 into into IN cord-010119-t1x9gknd 3743 6 VIP vip NN cord-010119-t1x9gknd 3743 7 boxes box NNS cord-010119-t1x9gknd 3743 8 for for IN cord-010119-t1x9gknd 3743 9 24h 24h NNS cord-010119-t1x9gknd 3743 10 at at IN cord-010119-t1x9gknd 3743 11 20 20 CD cord-010119-t1x9gknd 3743 12 - - SYM cord-010119-t1x9gknd 3743 13 248C 248c CD cord-010119-t1x9gknd 3743 14 before before IN cord-010119-t1x9gknd 3743 15 each each DT cord-010119-t1x9gknd 3743 16 test test NN cord-010119-t1x9gknd 3743 17 to to TO cord-010119-t1x9gknd 3743 18 mimic mimic VB cord-010119-t1x9gknd 3743 19 a a DT cord-010119-t1x9gknd 3743 20 worst bad JJS cord-010119-t1x9gknd 3743 21 - - HYPH cord-010119-t1x9gknd 3743 22 case case NN cord-010119-t1x9gknd 3743 23 scenario scenario NN cord-010119-t1x9gknd 3743 24 for for IN cord-010119-t1x9gknd 3743 25 remote remote JJ cord-010119-t1x9gknd 3743 26 blood blood NN cord-010119-t1x9gknd 3743 27 drives drive NNS cord-010119-t1x9gknd 3743 28 . . . cord-010119-t1x9gknd 3744 1 For for IN cord-010119-t1x9gknd 3744 2 the the DT cord-010119-t1x9gknd 3744 3 experimental experimental JJ cord-010119-t1x9gknd 3744 4 testing testing NN cord-010119-t1x9gknd 3744 5 , , , cord-010119-t1x9gknd 3744 6 500-mL 500-ml CD cord-010119-t1x9gknd 3744 7 WB WB NNP cord-010119-t1x9gknd 3744 8 bags bag NNS cord-010119-t1x9gknd 3744 9 were be VBD cord-010119-t1x9gknd 3744 10 filled fill VBN cord-010119-t1x9gknd 3744 11 with with IN cord-010119-t1x9gknd 3744 12 555 555 CD cord-010119-t1x9gknd 3744 13 mL ml NN cord-010119-t1x9gknd 3744 14 saline saline NN cord-010119-t1x9gknd 3744 15 0.9 0.9 CD cord-010119-t1x9gknd 3744 16 % % NN cord-010119-t1x9gknd 3744 17 at at IN cord-010119-t1x9gknd 3744 18 T T NNP cord-010119-t1x9gknd 3744 19 5 5 CD cord-010119-t1x9gknd 3744 20 308C 308C NNPS cord-010119-t1x9gknd 3744 21 to to TO cord-010119-t1x9gknd 3744 22 mimic mimic VB cord-010119-t1x9gknd 3744 23 freshly freshly RB cord-010119-t1x9gknd 3744 24 collected collect VBN cord-010119-t1x9gknd 3744 25 WB WB NNP cord-010119-t1x9gknd 3744 26 . . . cord-010119-t1x9gknd 3745 1 Probes probe NNS cord-010119-t1x9gknd 3745 2 were be VBD cord-010119-t1x9gknd 3745 3 positioned position VBN cord-010119-t1x9gknd 3745 4 inside inside IN cord-010119-t1x9gknd 3745 5 the the DT cord-010119-t1x9gknd 3745 6 saline saline NN cord-010119-t1x9gknd 3745 7 - - HYPH cord-010119-t1x9gknd 3745 8 filled fill VBN cord-010119-t1x9gknd 3745 9 bags bag NNS cord-010119-t1x9gknd 3745 10 to to TO cord-010119-t1x9gknd 3745 11 monitor monitor VB cord-010119-t1x9gknd 3745 12 temperature temperature NN cord-010119-t1x9gknd 3745 13 profiles profile NNS cord-010119-t1x9gknd 3745 14 of of IN cord-010119-t1x9gknd 3745 15 WBU WBU NNP cord-010119-t1x9gknd 3745 16 under under IN cord-010119-t1x9gknd 3745 17 extreme extreme JJ cord-010119-t1x9gknd 3745 18 winter winter NN cord-010119-t1x9gknd 3745 19 ( ( -LRB- cord-010119-t1x9gknd 3745 20 -308C -308C NNP cord-010119-t1x9gknd 3745 21 ) ) -RRB- cord-010119-t1x9gknd 3745 22 and and CC cord-010119-t1x9gknd 3745 23 summer summer NN cord-010119-t1x9gknd 3745 24 ( ( -LRB- cord-010119-t1x9gknd 3745 25 408C 408c CD cord-010119-t1x9gknd 3745 26 ) ) -RRB- cord-010119-t1x9gknd 3745 27 conditions condition NNS cord-010119-t1x9gknd 3745 28 . . . cord-010119-t1x9gknd 3746 1 Shipping shipping NN cord-010119-t1x9gknd 3746 2 boxes box NNS cord-010119-t1x9gknd 3746 3 were be VBD cord-010119-t1x9gknd 3746 4 filled fill VBN cord-010119-t1x9gknd 3746 5 with with IN cord-010119-t1x9gknd 3746 6 either either DT cord-010119-t1x9gknd 3746 7 one one CD cord-010119-t1x9gknd 3746 8 or or CC cord-010119-t1x9gknd 3746 9 six six CD cord-010119-t1x9gknd 3746 10 bags bag NNS cord-010119-t1x9gknd 3746 11 ( ( -LRB- cord-010119-t1x9gknd 3746 12 n5 n5 NNP cord-010119-t1x9gknd 3746 13 2 2 CD cord-010119-t1x9gknd 3746 14 ) ) -RRB- cord-010119-t1x9gknd 3746 15 . . . cord-010119-t1x9gknd 3747 1 Results/ Results/ . cord-010119-t1x9gknd 3748 1 Finding finding NN cord-010119-t1x9gknd 3748 2 : : : cord-010119-t1x9gknd 3749 1 The the DT cord-010119-t1x9gknd 3749 2 results result NNS cord-010119-t1x9gknd 3749 3 showed show VBD cord-010119-t1x9gknd 3749 4 that that IN cord-010119-t1x9gknd 3749 5 the the DT cord-010119-t1x9gknd 3749 6 thermoregulation thermoregulation NN cord-010119-t1x9gknd 3749 7 box box NN cord-010119-t1x9gknd 3749 8 prototype prototype NN cord-010119-t1x9gknd 3749 9 is be VBZ cord-010119-t1x9gknd 3749 10 able able JJ cord-010119-t1x9gknd 3749 11 to to TO cord-010119-t1x9gknd 3749 12 cool cool VB cord-010119-t1x9gknd 3749 13 WBU WBU NNP cord-010119-t1x9gknd 3749 14 bags bag NNS cord-010119-t1x9gknd 3749 15 under under IN cord-010119-t1x9gknd 3749 16 108C 108c CD cord-010119-t1x9gknd 3749 17 in in IN cord-010119-t1x9gknd 3749 18 4.55 4.55 CD cord-010119-t1x9gknd 3749 19 6 6 CD cord-010119-t1x9gknd 3749 20 0.62h 0.62h CD cord-010119-t1x9gknd 3749 21 and and CC cord-010119-t1x9gknd 3749 22 maintain maintain VB cord-010119-t1x9gknd 3749 23 their -PRON- PRP$ cord-010119-t1x9gknd 3749 24 internal internal JJ cord-010119-t1x9gknd 3749 25 temperature temperature NN cord-010119-t1x9gknd 3749 26 between between IN cord-010119-t1x9gknd 3749 27 18C 18C NNP cord-010119-t1x9gknd 3749 28 and and CC cord-010119-t1x9gknd 3749 29 108C 108c CD cord-010119-t1x9gknd 3749 30 for for IN cord-010119-t1x9gknd 3749 31 24h 24h NNS cord-010119-t1x9gknd 3749 32 with with IN cord-010119-t1x9gknd 3749 33 final final JJ cord-010119-t1x9gknd 3749 34 values value NNS cord-010119-t1x9gknd 3749 35 ranging range VBG cord-010119-t1x9gknd 3749 36 between between IN cord-010119-t1x9gknd 3749 37 6.38C 6.38c CD cord-010119-t1x9gknd 3749 38 and and CC cord-010119-t1x9gknd 3749 39 9.38C 9.38c CD cord-010119-t1x9gknd 3749 40 for for IN cord-010119-t1x9gknd 3749 41 the the DT cord-010119-t1x9gknd 3749 42 extreme extreme JJ cord-010119-t1x9gknd 3749 43 summer summer NN cord-010119-t1x9gknd 3749 44 scenario scenario NN cord-010119-t1x9gknd 3749 45 . . . cord-010119-t1x9gknd 3750 1 Similar similar JJ cord-010119-t1x9gknd 3750 2 results result NNS cord-010119-t1x9gknd 3750 3 were be VBD cord-010119-t1x9gknd 3750 4 obtained obtain VBN cord-010119-t1x9gknd 3750 5 for for IN cord-010119-t1x9gknd 3750 6 the the DT cord-010119-t1x9gknd 3750 7 extreme extreme JJ cord-010119-t1x9gknd 3750 8 winter winter NN cord-010119-t1x9gknd 3750 9 scenario scenario NN cord-010119-t1x9gknd 3750 10 ; ; : cord-010119-t1x9gknd 3750 11 units unit NNS cord-010119-t1x9gknd 3750 12 reached reach VBD cord-010119-t1x9gknd 3750 13 the the DT cord-010119-t1x9gknd 3750 14 108C 108c CD cord-010119-t1x9gknd 3750 15 threshold threshold NN cord-010119-t1x9gknd 3750 16 value value NN cord-010119-t1x9gknd 3750 17 in in IN cord-010119-t1x9gknd 3750 18 2.4 2.4 CD cord-010119-t1x9gknd 3750 19 6 6 CD cord-010119-t1x9gknd 3750 20 0.2h 0.2h CD cord-010119-t1x9gknd 3750 21 and and CC cord-010119-t1x9gknd 3750 22 the the DT cord-010119-t1x9gknd 3750 23 bags bag NNS cord-010119-t1x9gknd 3750 24 ' ' POS cord-010119-t1x9gknd 3750 25 internal internal JJ cord-010119-t1x9gknd 3750 26 temperatures temperature NNS cord-010119-t1x9gknd 3750 27 were be VBD cord-010119-t1x9gknd 3750 28 within within IN cord-010119-t1x9gknd 3750 29 the the DT cord-010119-t1x9gknd 3750 30 acceptable acceptable JJ cord-010119-t1x9gknd 3750 31 range range NN cord-010119-t1x9gknd 3750 32 for for IN cord-010119-t1x9gknd 3750 33 24h 24h NNS cord-010119-t1x9gknd 3750 34 . . . cord-010119-t1x9gknd 3751 1 Conclusion conclusion NN cord-010119-t1x9gknd 3751 2 : : : cord-010119-t1x9gknd 3752 1 The the DT cord-010119-t1x9gknd 3752 2 insulating insulating NN cord-010119-t1x9gknd 3752 3 and and CC cord-010119-t1x9gknd 3752 4 thermoregulation thermoregulation NN cord-010119-t1x9gknd 3752 5 system system NN cord-010119-t1x9gknd 3752 6 met meet VBD cord-010119-t1x9gknd 3752 7 HQ HQ NNP cord-010119-t1x9gknd 3752 8 performance performance NN cord-010119-t1x9gknd 3752 9 criteria criterion NNS cord-010119-t1x9gknd 3752 10 . . . cord-010119-t1x9gknd 3753 1 Preliminary preliminary JJ cord-010119-t1x9gknd 3753 2 results result NNS cord-010119-t1x9gknd 3753 3 showed show VBD cord-010119-t1x9gknd 3753 4 that that IN cord-010119-t1x9gknd 3753 5 PCM pcm NN cord-010119-t1x9gknd 3753 6 could could MD cord-010119-t1x9gknd 3753 7 be be VB cord-010119-t1x9gknd 3753 8 conditioned condition VBN cord-010119-t1x9gknd 3753 9 at at IN cord-010119-t1x9gknd 3753 10 temperatures temperature NNS cord-010119-t1x9gknd 3753 11 higher high JJR cord-010119-t1x9gknd 3753 12 than than IN cord-010119-t1x9gknd 3753 13 -138C -138c NN cord-010119-t1x9gknd 3753 14 without without IN cord-010119-t1x9gknd 3753 15 any any DT cord-010119-t1x9gknd 3753 16 significant significant JJ cord-010119-t1x9gknd 3753 17 impact impact NN cord-010119-t1x9gknd 3753 18 on on IN cord-010119-t1x9gknd 3753 19 the the DT cord-010119-t1x9gknd 3753 20 system system NN cord-010119-t1x9gknd 3753 21 performances performance NNS cord-010119-t1x9gknd 3753 22 . . . cord-010119-t1x9gknd 3754 1 HQ HQ NNP cord-010119-t1x9gknd 3754 2 is be VBZ cord-010119-t1x9gknd 3754 3 currently currently RB cord-010119-t1x9gknd 3754 4 validating validate VBG cord-010119-t1x9gknd 3754 5 the the DT cord-010119-t1x9gknd 3754 6 shipping shipping NN cord-010119-t1x9gknd 3754 7 box box NN cord-010119-t1x9gknd 3754 8 prototype prototype NN cord-010119-t1x9gknd 3754 9 performances performance NNS cord-010119-t1x9gknd 3754 10 . . . cord-010119-t1x9gknd 3755 1 Additionally additionally RB cord-010119-t1x9gknd 3755 2 , , , cord-010119-t1x9gknd 3755 3 we -PRON- PRP cord-010119-t1x9gknd 3755 4 are be VBP cord-010119-t1x9gknd 3755 5 working work VBG cord-010119-t1x9gknd 3755 6 on on IN cord-010119-t1x9gknd 3755 7 reducing reduce VBG cord-010119-t1x9gknd 3755 8 the the DT cord-010119-t1x9gknd 3755 9 PCM pcm NN cord-010119-t1x9gknd 3755 10 conditioning conditioning NN cord-010119-t1x9gknd 3755 11 time time NN cord-010119-t1x9gknd 3755 12 to to TO cord-010119-t1x9gknd 3755 13 optimize optimize VB cord-010119-t1x9gknd 3755 14 logistic logistic JJ cord-010119-t1x9gknd 3755 15 operations operation NNS cord-010119-t1x9gknd 3755 16 . . . cord-010119-t1x9gknd 3756 1 As as IN cord-010119-t1x9gknd 3756 2 this this DT cord-010119-t1x9gknd 3756 3 packaging packaging NN cord-010119-t1x9gknd 3756 4 has have VBZ cord-010119-t1x9gknd 3756 5 many many JJ cord-010119-t1x9gknd 3756 6 advantages advantage NNS cord-010119-t1x9gknd 3756 7 in in IN cord-010119-t1x9gknd 3756 8 terms term NNS cord-010119-t1x9gknd 3756 9 of of IN cord-010119-t1x9gknd 3756 10 durability durability NN cord-010119-t1x9gknd 3756 11 , , , cord-010119-t1x9gknd 3756 12 price price NN cord-010119-t1x9gknd 3756 13 and and CC cord-010119-t1x9gknd 3756 14 convenience convenience NN cord-010119-t1x9gknd 3756 15 , , , cord-010119-t1x9gknd 3756 16 HQ HQ NNP cord-010119-t1x9gknd 3756 17 intends intend VBZ cord-010119-t1x9gknd 3756 18 to to TO cord-010119-t1x9gknd 3756 19 evaluate evaluate VB cord-010119-t1x9gknd 3756 20 this this DT cord-010119-t1x9gknd 3756 21 system system NN cord-010119-t1x9gknd 3756 22 for for IN cord-010119-t1x9gknd 3756 23 the the DT cord-010119-t1x9gknd 3756 24 packaging packaging NN cord-010119-t1x9gknd 3756 25 and and CC cord-010119-t1x9gknd 3756 26 transport transport NN cord-010119-t1x9gknd 3756 27 of of IN cord-010119-t1x9gknd 3756 28 other other JJ cord-010119-t1x9gknd 3756 29 lines line NNS cord-010119-t1x9gknd 3756 30 of of IN cord-010119-t1x9gknd 3756 31 blood blood NN cord-010119-t1x9gknd 3756 32 products product NNS cord-010119-t1x9gknd 3756 33 . . . cord-010119-t1x9gknd 3757 1 Stuart Stuart NNP cord-010119-t1x9gknd 3757 2 Weisberg Weisberg NNP cord-010119-t1x9gknd 3757 3 * * NFP cord-010119-t1x9gknd 3757 4 1 1 CD cord-010119-t1x9gknd 3757 5 , , , cord-010119-t1x9gknd 3757 6 Christopher Christopher NNP cord-010119-t1x9gknd 3757 7 C. C. NNP cord-010119-t1x9gknd 3757 8 C C NNP cord-010119-t1x9gknd 3757 9 Silliman Silliman NNP cord-010119-t1x9gknd 3757 10 2 2 CD cord-010119-t1x9gknd 3757 11 , , , cord-010119-t1x9gknd 3757 12 Beth Beth NNP cord-010119-t1x9gknd 3757 13 Shaz Shaz NNP cord-010119-t1x9gknd 3757 14 1 1 CD cord-010119-t1x9gknd 3757 15 , , , cord-010119-t1x9gknd 3757 16 Marguerite Marguerite NNP cord-010119-t1x9gknd 3757 17 Kelher Kelher NNP cord-010119-t1x9gknd 3757 18 2 2 CD cord-010119-t1x9gknd 3757 19 and and CC cord-010119-t1x9gknd 3757 20 Claudia Claudia NNP cord-010119-t1x9gknd 3757 21 S. S. NNP cord-010119-t1x9gknd 3757 22 Cohn Cohn NNP cord-010119-t1x9gknd 3757 23 3 3 CD cord-010119-t1x9gknd 3757 24 . . . cord-010119-t1x9gknd 3758 1 1 1 CD cord-010119-t1x9gknd 3758 2 New New NNP cord-010119-t1x9gknd 3758 3 York York NNP cord-010119-t1x9gknd 3758 4 Blood Blood NNP cord-010119-t1x9gknd 3758 5 Center Center NNP cord-010119-t1x9gknd 3758 6 , , , cord-010119-t1x9gknd 3758 7 2 2 CD cord-010119-t1x9gknd 3758 8 Bonfils Bonfils NNP cord-010119-t1x9gknd 3758 9 Blood Blood NNP cord-010119-t1x9gknd 3758 10 Center Center NNP cord-010119-t1x9gknd 3758 11 , , , cord-010119-t1x9gknd 3758 12 3 3 CD cord-010119-t1x9gknd 3758 13 Department Department NNP cord-010119-t1x9gknd 3758 14 of of IN cord-010119-t1x9gknd 3758 15 Laboratory Laboratory NNP cord-010119-t1x9gknd 3758 16 Medicine Medicine NNP cord-010119-t1x9gknd 3758 17 and and CC cord-010119-t1x9gknd 3758 18 Pathology Pathology NNP cord-010119-t1x9gknd 3758 19 , , , cord-010119-t1x9gknd 3758 20 University University NNP cord-010119-t1x9gknd 3758 21 of of IN cord-010119-t1x9gknd 3758 22 Minnesota Minnesota NNP cord-010119-t1x9gknd 3758 23 Background Background NNP cord-010119-t1x9gknd 3758 24 / / SYM cord-010119-t1x9gknd 3758 25 Case Case NNP cord-010119-t1x9gknd 3758 26 Studies Studies NNPS cord-010119-t1x9gknd 3758 27 : : : cord-010119-t1x9gknd 3759 1 Platelets platelet NNS cord-010119-t1x9gknd 3759 2 collected collect VBD cord-010119-t1x9gknd 3759 3 and and CC cord-010119-t1x9gknd 3759 4 stored store VBN cord-010119-t1x9gknd 3759 5 in in IN cord-010119-t1x9gknd 3759 6 platelet platelet NN cord-010119-t1x9gknd 3759 7 additive additive NN cord-010119-t1x9gknd 3759 8 solution solution NN cord-010119-t1x9gknd 3760 1 ( ( -LRB- cord-010119-t1x9gknd 3760 2 PAS pas NN cord-010119-t1x9gknd 3760 3 ) ) -RRB- cord-010119-t1x9gknd 3760 4 reduce reduce VB cord-010119-t1x9gknd 3760 5 recipient recipient NN cord-010119-t1x9gknd 3760 6 exposure exposure NN cord-010119-t1x9gknd 3760 7 to to IN cord-010119-t1x9gknd 3760 8 donor donor NN cord-010119-t1x9gknd 3760 9 plasma plasma NN cord-010119-t1x9gknd 3760 10 components component NNS cord-010119-t1x9gknd 3760 11 . . . cord-010119-t1x9gknd 3761 1 To to TO cord-010119-t1x9gknd 3761 2 better better RB cord-010119-t1x9gknd 3761 3 define define VB cord-010119-t1x9gknd 3761 4 the the DT cord-010119-t1x9gknd 3761 5 effects effect NNS cord-010119-t1x9gknd 3761 6 of of IN cord-010119-t1x9gknd 3761 7 PAS pas NN cord-010119-t1x9gknd 3761 8 on on IN cord-010119-t1x9gknd 3761 9 platelet platelet NN cord-010119-t1x9gknd 3761 10 supernatant supernatant JJ cord-010119-t1x9gknd 3761 11 composition composition NN cord-010119-t1x9gknd 3761 12 , , , cord-010119-t1x9gknd 3761 13 we -PRON- PRP cord-010119-t1x9gknd 3761 14 compared compare VBD cord-010119-t1x9gknd 3761 15 total total JJ cord-010119-t1x9gknd 3761 16 protein protein NN cord-010119-t1x9gknd 3761 17 , , , cord-010119-t1x9gknd 3761 18 isohemagglutinin isohemagglutinin NNP cord-010119-t1x9gknd 3761 19 titers titer NNS cord-010119-t1x9gknd 3761 20 , , , cord-010119-t1x9gknd 3761 21 HLA HLA NNP cord-010119-t1x9gknd 3761 22 antibodies antibody NNS cord-010119-t1x9gknd 3761 23 and and CC cord-010119-t1x9gknd 3761 24 in in IN cord-010119-t1x9gknd 3761 25 vitro vitro FW cord-010119-t1x9gknd 3761 26 neutrophil neutrophil NN cord-010119-t1x9gknd 3761 27 ( ( -LRB- cord-010119-t1x9gknd 3761 28 PMN pmn NN cord-010119-t1x9gknd 3761 29 ) ) -RRB- cord-010119-t1x9gknd 3761 30 priming prime VBG cord-010119-t1x9gknd 3761 31 activity activity NN cord-010119-t1x9gknd 3761 32 in in IN cord-010119-t1x9gknd 3761 33 supernatants supernatant NNS cord-010119-t1x9gknd 3761 34 of of IN cord-010119-t1x9gknd 3761 35 PAS pas NN cord-010119-t1x9gknd 3761 36 - - HYPH cord-010119-t1x9gknd 3761 37 C C NNP cord-010119-t1x9gknd 3761 38 platelets platelet NNS cord-010119-t1x9gknd 3761 39 to to IN cord-010119-t1x9gknd 3761 40 plasma plasma NN cord-010119-t1x9gknd 3761 41 platelets platelet NNS cord-010119-t1x9gknd 3761 42 . . . cord-010119-t1x9gknd 3762 1 Study Study NNP cord-010119-t1x9gknd 3762 2 Design Design NNP cord-010119-t1x9gknd 3762 3 / / SYM cord-010119-t1x9gknd 3762 4 Methods method NNS cord-010119-t1x9gknd 3762 5 : : : cord-010119-t1x9gknd 3763 1 Apheresis Apheresis NNP cord-010119-t1x9gknd 3763 2 platelets platelet NNS cord-010119-t1x9gknd 3763 3 from from IN cord-010119-t1x9gknd 3763 4 group group NN cord-010119-t1x9gknd 3763 5 O o NN cord-010119-t1x9gknd 3763 6 blood blood NN cord-010119-t1x9gknd 3763 7 donors donor NNS cord-010119-t1x9gknd 3763 8 were be VBD cord-010119-t1x9gknd 3763 9 collected collect VBN cord-010119-t1x9gknd 3763 10 into into IN cord-010119-t1x9gknd 3763 11 either either DT cord-010119-t1x9gknd 3763 12 100 100 CD cord-010119-t1x9gknd 3763 13 % % NN cord-010119-t1x9gknd 3763 14 donor donor NN cord-010119-t1x9gknd 3763 15 plasma plasma NN cord-010119-t1x9gknd 3763 16 ( ( -LRB- cord-010119-t1x9gknd 3763 17 n550 n550 NNP cord-010119-t1x9gknd 3763 18 ) ) -RRB- cord-010119-t1x9gknd 3763 19 or or CC cord-010119-t1x9gknd 3763 20 65 65 CD cord-010119-t1x9gknd 3763 21 % % NN cord-010119-t1x9gknd 3763 22 PAS-3 PAS-3 NNP cord-010119-t1x9gknd 3763 23 / / SYM cord-010119-t1x9gknd 3763 24 35 35 CD cord-010119-t1x9gknd 3763 25 % % NN cord-010119-t1x9gknd 3763 26 donor donor NN cord-010119-t1x9gknd 3763 27 plasma plasma NN cord-010119-t1x9gknd 3763 28 ( ( -LRB- cord-010119-t1x9gknd 3763 29 n550 n550 NNP cord-010119-t1x9gknd 3763 30 ) ) -RRB- cord-010119-t1x9gknd 3763 31 . . . cord-010119-t1x9gknd 3764 1 Within within IN cord-010119-t1x9gknd 3764 2 12 12 CD cord-010119-t1x9gknd 3764 3 hours hour NNS cord-010119-t1x9gknd 3764 4 of of IN cord-010119-t1x9gknd 3764 5 collection collection NN cord-010119-t1x9gknd 3764 6 , , , cord-010119-t1x9gknd 3764 7 samples sample NNS cord-010119-t1x9gknd 3764 8 of of IN cord-010119-t1x9gknd 3764 9 the the DT cord-010119-t1x9gknd 3764 10 product product NN cord-010119-t1x9gknd 3764 11 supernatant supernatant NN cord-010119-t1x9gknd 3764 12 were be VBD cord-010119-t1x9gknd 3764 13 frozen freeze VBN cord-010119-t1x9gknd 3764 14 , , , cord-010119-t1x9gknd 3764 15 assayed assay VBN cord-010119-t1x9gknd 3764 16 for for IN cord-010119-t1x9gknd 3764 17 total total JJ cord-010119-t1x9gknd 3764 18 protein protein NN cord-010119-t1x9gknd 3764 19 concentration concentration NN cord-010119-t1x9gknd 3764 20 , , , cord-010119-t1x9gknd 3764 21 anti anti NNP cord-010119-t1x9gknd 3764 22 - - NNP cord-010119-t1x9gknd 3764 23 A a JJ cord-010119-t1x9gknd 3764 24 and and CC cord-010119-t1x9gknd 3764 25 anti anti JJ cord-010119-t1x9gknd 3764 26 - - JJ cord-010119-t1x9gknd 3764 27 B b JJ cord-010119-t1x9gknd 3764 28 titer titer NN cord-010119-t1x9gknd 3764 29 , , , cord-010119-t1x9gknd 3764 30 and and CC cord-010119-t1x9gknd 3764 31 PMN PMN NNP cord-010119-t1x9gknd 3764 32 priming prime VBG cord-010119-t1x9gknd 3764 33 activity activity NN cord-010119-t1x9gknd 3764 34 within within IN cord-010119-t1x9gknd 3764 35 the the DT cord-010119-t1x9gknd 3764 36 total total JJ cord-010119-t1x9gknd 3764 37 and and CC cord-010119-t1x9gknd 3764 38 lipid lipid NN cord-010119-t1x9gknd 3764 39 extractable extractable JJ cord-010119-t1x9gknd 3764 40 fractions fraction NNS cord-010119-t1x9gknd 3764 41 . . . cord-010119-t1x9gknd 3765 1 All all DT cord-010119-t1x9gknd 3765 2 samples sample NNS cord-010119-t1x9gknd 3765 3 were be VBD cord-010119-t1x9gknd 3765 4 screened screen VBN cord-010119-t1x9gknd 3765 5 for for IN cord-010119-t1x9gknd 3765 6 HLA HLA NNP cord-010119-t1x9gknd 3765 7 antibodies antibody NNS cord-010119-t1x9gknd 3765 8 . . . cord-010119-t1x9gknd 3766 1 Screen screen NN cord-010119-t1x9gknd 3766 2 - - HYPH cord-010119-t1x9gknd 3766 3 positive positive JJ cord-010119-t1x9gknd 3766 4 samples sample NNS cord-010119-t1x9gknd 3766 5 were be VBD cord-010119-t1x9gknd 3766 6 tested test VBN cord-010119-t1x9gknd 3766 7 using use VBG cord-010119-t1x9gknd 3766 8 Luminex Luminex NNP cord-010119-t1x9gknd 3766 9 single single JJ cord-010119-t1x9gknd 3766 10 bead bead NN cord-010119-t1x9gknd 3766 11 assays assay NNS cord-010119-t1x9gknd 3766 12 for for IN cord-010119-t1x9gknd 3766 13 antibody antibody NN cord-010119-t1x9gknd 3766 14 strength strength NN cord-010119-t1x9gknd 3766 15 and and CC cord-010119-t1x9gknd 3766 16 specificity specificity NN cord-010119-t1x9gknd 3766 17 . . . cord-010119-t1x9gknd 3767 1 Soluble soluble JJ cord-010119-t1x9gknd 3767 2 CD40 CD40 NNP cord-010119-t1x9gknd 3767 3 ligand ligand NN cord-010119-t1x9gknd 3767 4 ( ( -LRB- cord-010119-t1x9gknd 3767 5 sCD40L sCD40L NNP cord-010119-t1x9gknd 3767 6 ) ) -RRB- cord-010119-t1x9gknd 3767 7 was be VBD cord-010119-t1x9gknd 3767 8 measured measure VBN cord-010119-t1x9gknd 3767 9 using use VBG cord-010119-t1x9gknd 3767 10 solid solid JJ cord-010119-t1x9gknd 3767 11 - - HYPH cord-010119-t1x9gknd 3767 12 phase phase NN cord-010119-t1x9gknd 3767 13 ELISA ELISA NNP cord-010119-t1x9gknd 3767 14 . . . cord-010119-t1x9gknd 3768 1 Results result NNS cord-010119-t1x9gknd 3768 2 / / SYM cord-010119-t1x9gknd 3768 3 Findings finding NNS cord-010119-t1x9gknd 3768 4 : : : cord-010119-t1x9gknd 3769 1 Supernatants supernatant NNS cord-010119-t1x9gknd 3769 2 of of IN cord-010119-t1x9gknd 3769 3 PAS pas NN cord-010119-t1x9gknd 3769 4 - - HYPH cord-010119-t1x9gknd 3769 5 C C NNP cord-010119-t1x9gknd 3769 6 platelets platelet NNS cord-010119-t1x9gknd 3769 7 had have VBD cord-010119-t1x9gknd 3769 8 significantly significantly RB cord-010119-t1x9gknd 3769 9 lower low JJR cord-010119-t1x9gknd 3769 10 total total JJ cord-010119-t1x9gknd 3769 11 protein protein NN cord-010119-t1x9gknd 3769 12 concentration concentration NN cord-010119-t1x9gknd 3769 13 , , , cord-010119-t1x9gknd 3769 14 anti anti NNP cord-010119-t1x9gknd 3769 15 - - NNP cord-010119-t1x9gknd 3769 16 A a JJ cord-010119-t1x9gknd 3769 17 and and CC cord-010119-t1x9gknd 3769 18 anti anti JJ cord-010119-t1x9gknd 3769 19 - - JJ cord-010119-t1x9gknd 3769 20 B b JJ cord-010119-t1x9gknd 3769 21 titers titer NNS cord-010119-t1x9gknd 3769 22 compared compare VBN cord-010119-t1x9gknd 3769 23 to to IN cord-010119-t1x9gknd 3769 24 plasma plasma NN cord-010119-t1x9gknd 3769 25 platelets platelet NNS cord-010119-t1x9gknd 3769 26 . . . cord-010119-t1x9gknd 3770 1 There there EX cord-010119-t1x9gknd 3770 2 was be VBD cord-010119-t1x9gknd 3770 3 no no DT cord-010119-t1x9gknd 3770 4 significant significant JJ cord-010119-t1x9gknd 3770 5 difference difference NN cord-010119-t1x9gknd 3770 6 in in IN cord-010119-t1x9gknd 3770 7 the the DT cord-010119-t1x9gknd 3770 8 number number NN cord-010119-t1x9gknd 3770 9 of of IN cord-010119-t1x9gknd 3770 10 HLA HLA NNP cord-010119-t1x9gknd 3770 11 - - HYPH cord-010119-t1x9gknd 3770 12 antibody antibody NN cord-010119-t1x9gknd 3770 13 screen screen NN cord-010119-t1x9gknd 3770 14 positive positive JJ cord-010119-t1x9gknd 3770 15 PAS pas NN cord-010119-t1x9gknd 3770 16 - - HYPH cord-010119-t1x9gknd 3770 17 C c NN cord-010119-t1x9gknd 3770 18 ( ( -LRB- cord-010119-t1x9gknd 3770 19 3/50 3/50 CD cord-010119-t1x9gknd 3770 20 products product NNS cord-010119-t1x9gknd 3770 21 ) ) -RRB- cord-010119-t1x9gknd 3770 22 compared compare VBN cord-010119-t1x9gknd 3770 23 to to IN cord-010119-t1x9gknd 3770 24 plasma plasma NN cord-010119-t1x9gknd 3770 25 platelets platelet NNS cord-010119-t1x9gknd 3770 26 ( ( -LRB- cord-010119-t1x9gknd 3770 27 2/50 2/50 CD cord-010119-t1x9gknd 3770 28 products product NNS cord-010119-t1x9gknd 3770 29 ) ) -RRB- cord-010119-t1x9gknd 3770 30 ; ; : cord-010119-t1x9gknd 3770 31 however however RB cord-010119-t1x9gknd 3770 32 , , , cord-010119-t1x9gknd 3770 33 the the DT cord-010119-t1x9gknd 3770 34 HLA HLA NNP cord-010119-t1x9gknd 3770 35 - - HYPH cord-010119-t1x9gknd 3770 36 antibody antibody NN cord-010119-t1x9gknd 3770 37 screen screen NN cord-010119-t1x9gknd 3770 38 - - HYPH cord-010119-t1x9gknd 3770 39 positive positive JJ cord-010119-t1x9gknd 3770 40 supernatants supernatant NNS cord-010119-t1x9gknd 3770 41 of of IN cord-010119-t1x9gknd 3770 42 PAS-86A pas-86a NN cord-010119-t1x9gknd 3770 43 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 3770 44 2017 2017 CD cord-010119-t1x9gknd 3770 45 Vol Vol NNP cord-010119-t1x9gknd 3770 46 . . . cord-010119-t1x9gknd 3771 1 57 57 CD cord-010119-t1x9gknd 3772 1 Supplement supplement NN cord-010119-t1x9gknd 3772 2 S3 S3 NNP cord-010119-t1x9gknd 3772 3 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 3772 4 C c NN cord-010119-t1x9gknd 3772 5 platelets platelet NNS cord-010119-t1x9gknd 3772 6 had have VBD cord-010119-t1x9gknd 3772 7 fewer few JJR cord-010119-t1x9gknd 3772 8 HLA HLA NNP cord-010119-t1x9gknd 3772 9 specificities specificity NNS cord-010119-t1x9gknd 3772 10 ( ( -LRB- cord-010119-t1x9gknd 3772 11 2 2 CD cord-010119-t1x9gknd 3772 12 specificities specificity NNS cord-010119-t1x9gknd 3772 13 ) ) -RRB- cord-010119-t1x9gknd 3772 14 compared compare VBN cord-010119-t1x9gknd 3772 15 to to IN cord-010119-t1x9gknd 3772 16 those those DT cord-010119-t1x9gknd 3772 17 of of IN cord-010119-t1x9gknd 3772 18 the the DT cord-010119-t1x9gknd 3772 19 plasma plasma NN cord-010119-t1x9gknd 3772 20 platelets platelet NNS cord-010119-t1x9gknd 3772 21 ( ( -LRB- cord-010119-t1x9gknd 3772 22 18 18 CD cord-010119-t1x9gknd 3772 23 specificities specificity NNS cord-010119-t1x9gknd 3772 24 ) ) -RRB- cord-010119-t1x9gknd 3772 25 . . . cord-010119-t1x9gknd 3773 1 PMN pmn NN cord-010119-t1x9gknd 3773 2 priming prime VBG cord-010119-t1x9gknd 3773 3 activity activity NN cord-010119-t1x9gknd 3773 4 was be VBD cord-010119-t1x9gknd 3773 5 significantly significantly RB cord-010119-t1x9gknd 3773 6 increased increase VBN cord-010119-t1x9gknd 3773 7 in in IN cord-010119-t1x9gknd 3773 8 the the DT cord-010119-t1x9gknd 3773 9 supernatant supernatant NN cord-010119-t1x9gknd 3773 10 of of IN cord-010119-t1x9gknd 3773 11 PAS pas NN cord-010119-t1x9gknd 3773 12 - - HYPH cord-010119-t1x9gknd 3773 13 C C NNP cord-010119-t1x9gknd 3773 14 platelets platelet NNS cord-010119-t1x9gknd 3773 15 . . . cord-010119-t1x9gknd 3774 1 The the DT cord-010119-t1x9gknd 3774 2 lipid lipid NN cord-010119-t1x9gknd 3774 3 extractable extractable JJ cord-010119-t1x9gknd 3774 4 fraction fraction NN cord-010119-t1x9gknd 3774 5 was be VBD cord-010119-t1x9gknd 3774 6 not not RB cord-010119-t1x9gknd 3774 7 affected affect VBN cord-010119-t1x9gknd 3774 8 ; ; : cord-010119-t1x9gknd 3774 9 however however RB cord-010119-t1x9gknd 3774 10 sCD40L scd40l JJ cord-010119-t1x9gknd 3774 11 levels level NNS cord-010119-t1x9gknd 3774 12 were be VBD cord-010119-t1x9gknd 3774 13 increased increase VBN cord-010119-t1x9gknd 3774 14 in in IN cord-010119-t1x9gknd 3774 15 the the DT cord-010119-t1x9gknd 3774 16 supernatant supernatant NN cord-010119-t1x9gknd 3774 17 of of IN cord-010119-t1x9gknd 3774 18 PAS pas NN cord-010119-t1x9gknd 3774 19 - - HYPH cord-010119-t1x9gknd 3774 20 C c NN cord-010119-t1x9gknd 3774 21 compared compare VBN cord-010119-t1x9gknd 3774 22 to to IN cord-010119-t1x9gknd 3774 23 plasma plasma NN cord-010119-t1x9gknd 3774 24 platelets platelet NNS cord-010119-t1x9gknd 3774 25 ( ( -LRB- cord-010119-t1x9gknd 3774 26 Table table NN cord-010119-t1x9gknd 3774 27 1 1 CD cord-010119-t1x9gknd 3774 28 ) ) -RRB- cord-010119-t1x9gknd 3774 29 . . . cord-010119-t1x9gknd 3775 1 Conclusion conclusion NN cord-010119-t1x9gknd 3775 2 : : : cord-010119-t1x9gknd 3775 3 Decreased decrease VBN cord-010119-t1x9gknd 3775 4 plasma plasma NN cord-010119-t1x9gknd 3775 5 proteins protein NNS cord-010119-t1x9gknd 3775 6 likely likely RB cord-010119-t1x9gknd 3775 7 underlie underlie VBP cord-010119-t1x9gknd 3775 8 lower low JJR cord-010119-t1x9gknd 3775 9 rates rate NNS cord-010119-t1x9gknd 3775 10 of of IN cord-010119-t1x9gknd 3775 11 allergic allergic JJ cord-010119-t1x9gknd 3775 12 and and CC cord-010119-t1x9gknd 3775 13 febrile febrile JJ cord-010119-t1x9gknd 3775 14 non non JJ cord-010119-t1x9gknd 3775 15 - - JJ cord-010119-t1x9gknd 3775 16 hemolytic hemolytic JJ cord-010119-t1x9gknd 3775 17 transfusion transfusion NN cord-010119-t1x9gknd 3775 18 reactions reaction NNS cord-010119-t1x9gknd 3775 19 seen see VBN cord-010119-t1x9gknd 3775 20 with with IN cord-010119-t1x9gknd 3775 21 use use NN cord-010119-t1x9gknd 3775 22 of of IN cord-010119-t1x9gknd 3775 23 PAS pas NN cord-010119-t1x9gknd 3775 24 - - HYPH cord-010119-t1x9gknd 3775 25 C C NNP cord-010119-t1x9gknd 3775 26 platelets platelet NNS cord-010119-t1x9gknd 3775 27 . . . cord-010119-t1x9gknd 3776 1 Decreased decrease VBN cord-010119-t1x9gknd 3777 1 anti anti JJ cord-010119-t1x9gknd 3777 2 - - NNP cord-010119-t1x9gknd 3777 3 A a JJ cord-010119-t1x9gknd 3777 4 and and CC cord-010119-t1x9gknd 3777 5 anti anti JJ cord-010119-t1x9gknd 3777 6 - - JJ cord-010119-t1x9gknd 3777 7 B b JJ cord-010119-t1x9gknd 3777 8 titers titer NNS cord-010119-t1x9gknd 3777 9 may may MD cord-010119-t1x9gknd 3777 10 prevent prevent VB cord-010119-t1x9gknd 3777 11 hemolysis hemolysis NN cord-010119-t1x9gknd 3777 12 from from IN cord-010119-t1x9gknd 3777 13 minor minor JJ cord-010119-t1x9gknd 3777 14 ABO ABO NNP cord-010119-t1x9gknd 3777 15 mismatch mismatch NN cord-010119-t1x9gknd 3777 16 . . . cord-010119-t1x9gknd 3778 1 Lower low JJR cord-010119-t1x9gknd 3778 2 HLA HLA NNP cord-010119-t1x9gknd 3778 3 - - HYPH cord-010119-t1x9gknd 3778 4 antibody antibody NN cord-010119-t1x9gknd 3778 5 specificities specificity NNS cord-010119-t1x9gknd 3778 6 may may MD cord-010119-t1x9gknd 3778 7 mitigate mitigate VB cord-010119-t1x9gknd 3778 8 transfusion transfusion NN cord-010119-t1x9gknd 3778 9 related relate VBN cord-010119-t1x9gknd 3778 10 acute acute JJ cord-010119-t1x9gknd 3778 11 lung lung NN cord-010119-t1x9gknd 3778 12 injury injury NN cord-010119-t1x9gknd 3778 13 ( ( -LRB- cord-010119-t1x9gknd 3778 14 TRALI TRALI NNP cord-010119-t1x9gknd 3778 15 ) ) -RRB- cord-010119-t1x9gknd 3778 16 . . . cord-010119-t1x9gknd 3779 1 Increased increase VBN cord-010119-t1x9gknd 3779 2 PMN PMN NNP cord-010119-t1x9gknd 3779 3 priming prime VBG cord-010119-t1x9gknd 3779 4 by by IN cord-010119-t1x9gknd 3779 5 PAS pas NN cord-010119-t1x9gknd 3779 6 - - HYPH cord-010119-t1x9gknd 3779 7 C C NNP cord-010119-t1x9gknd 3779 8 platelets platelet NNS cord-010119-t1x9gknd 3779 9 is be VBZ cord-010119-t1x9gknd 3779 10 likely likely JJ cord-010119-t1x9gknd 3779 11 due due JJ cord-010119-t1x9gknd 3779 12 to to IN cord-010119-t1x9gknd 3779 13 platelet platelet NN cord-010119-t1x9gknd 3779 14 membrane membrane NN cord-010119-t1x9gknd 3779 15 release release NN cord-010119-t1x9gknd 3779 16 of of IN cord-010119-t1x9gknd 3779 17 sCD40L scd40l NN cord-010119-t1x9gknd 3779 18 and and CC cord-010119-t1x9gknd 3779 19 not not RB cord-010119-t1x9gknd 3779 20 bioactive bioactive JJ cord-010119-t1x9gknd 3779 21 lipids lipid NNS cord-010119-t1x9gknd 3779 22 . . . cord-010119-t1x9gknd 3780 1 Although although IN cord-010119-t1x9gknd 3780 2 sCD40L sCD40L NNP cord-010119-t1x9gknd 3780 3 has have VBZ cord-010119-t1x9gknd 3780 4 been be VBN cord-010119-t1x9gknd 3780 5 associated associate VBN cord-010119-t1x9gknd 3780 6 with with IN cord-010119-t1x9gknd 3780 7 TRALI TRALI NNP cord-010119-t1x9gknd 3780 8 , , , cord-010119-t1x9gknd 3780 9 only only RB cord-010119-t1x9gknd 3780 10 PMN PMN NNP cord-010119-t1x9gknd 3780 11 priming prime VBG cord-010119-t1x9gknd 3780 12 with with IN cord-010119-t1x9gknd 3780 13 lipid lipid NN cord-010119-t1x9gknd 3780 14 -not -not HYPH cord-010119-t1x9gknd 3780 15 cytokine cytokine NN cord-010119-t1x9gknd 3780 16 -agents -agent NNS cord-010119-t1x9gknd 3780 17 has have VBZ cord-010119-t1x9gknd 3780 18 been be VBN cord-010119-t1x9gknd 3780 19 causally causally RB cord-010119-t1x9gknd 3780 20 linked link VBN cord-010119-t1x9gknd 3780 21 with with IN cord-010119-t1x9gknd 3780 22 TRALI TRALI NNP cord-010119-t1x9gknd 3780 23 . . . cord-010119-t1x9gknd 3781 1 The the DT cord-010119-t1x9gknd 3781 2 mechanism mechanism NN cord-010119-t1x9gknd 3781 3 and and CC cord-010119-t1x9gknd 3781 4 clinical clinical JJ cord-010119-t1x9gknd 3781 5 impact impact NN cord-010119-t1x9gknd 3781 6 of of IN cord-010119-t1x9gknd 3781 7 increased increase VBN cord-010119-t1x9gknd 3781 8 sCD40L scd40l NN cord-010119-t1x9gknd 3781 9 in in IN cord-010119-t1x9gknd 3781 10 PAS pas NN cord-010119-t1x9gknd 3781 11 - - HYPH cord-010119-t1x9gknd 3781 12 C C NNP cord-010119-t1x9gknd 3781 13 platelets platelet NNS cord-010119-t1x9gknd 3781 14 remain remain VBP cord-010119-t1x9gknd 3781 15 to to TO cord-010119-t1x9gknd 3781 16 be be VB cord-010119-t1x9gknd 3781 17 elucidated elucidate VBN cord-010119-t1x9gknd 3781 18 . . . cord-010119-t1x9gknd 3782 1 Background Background NNP cord-010119-t1x9gknd 3782 2 / / SYM cord-010119-t1x9gknd 3782 3 Case Case NNP cord-010119-t1x9gknd 3782 4 Studies Studies NNPS cord-010119-t1x9gknd 3783 1 : : : cord-010119-t1x9gknd 3783 2 Current current JJ cord-010119-t1x9gknd 3783 3 guidelines guideline NNS cord-010119-t1x9gknd 3783 4 require require VBP cord-010119-t1x9gknd 3783 5 a a DT cord-010119-t1x9gknd 3783 6 reduction reduction NN cord-010119-t1x9gknd 3783 7 of of IN cord-010119-t1x9gknd 3783 8 residual residual JJ cord-010119-t1x9gknd 3783 9 white white JJ cord-010119-t1x9gknd 3783 10 blood blood NN cord-010119-t1x9gknd 3783 11 cells cell NNS cord-010119-t1x9gknd 3783 12 ( ( -LRB- cord-010119-t1x9gknd 3783 13 rWBC rWBC NNP cord-010119-t1x9gknd 3783 14 ) ) -RRB- cord-010119-t1x9gknd 3783 15 below below IN cord-010119-t1x9gknd 3783 16 5x10 5x10 CD cord-010119-t1x9gknd 3783 17 6 6 CD cord-010119-t1x9gknd 3783 18 WBC WBC NNP cord-010119-t1x9gknd 3783 19 in in IN cord-010119-t1x9gknd 3783 20 US US NNP cord-010119-t1x9gknd 3783 21 and and CC cord-010119-t1x9gknd 3783 22 1x10 1x10 CD cord-010119-t1x9gknd 3783 23 6 6 CD cord-010119-t1x9gknd 3783 24 WBC WBC NNP cord-010119-t1x9gknd 3783 25 in in IN cord-010119-t1x9gknd 3783 26 Europe Europe NNP cord-010119-t1x9gknd 3783 27 , , , cord-010119-t1x9gknd 3783 28 per per IN cord-010119-t1x9gknd 3783 29 unit unit NN cord-010119-t1x9gknd 3783 30 . . . cord-010119-t1x9gknd 3784 1 The the DT cord-010119-t1x9gknd 3784 2 established establish VBN cord-010119-t1x9gknd 3784 3 reference reference NN cord-010119-t1x9gknd 3784 4 method method NN cord-010119-t1x9gknd 3784 5 for for IN cord-010119-t1x9gknd 3784 6 testing test VBG cord-010119-t1x9gknd 3784 7 rWBC rwbc JJ cord-010119-t1x9gknd 3784 8 in in IN cord-010119-t1x9gknd 3784 9 platelet platelet NN cord-010119-t1x9gknd 3784 10 ( ( -LRB- cord-010119-t1x9gknd 3784 11 PLT PLT NNP cord-010119-t1x9gknd 3784 12 ) ) -RRB- cord-010119-t1x9gknd 3784 13 and and CC cord-010119-t1x9gknd 3784 14 red red JJ cord-010119-t1x9gknd 3784 15 blood blood NN cord-010119-t1x9gknd 3784 16 cell cell NN cord-010119-t1x9gknd 3784 17 ( ( -LRB- cord-010119-t1x9gknd 3784 18 RBC RBC NNP cord-010119-t1x9gknd 3784 19 ) ) -RRB- cord-010119-t1x9gknd 3784 20 products product NNS cord-010119-t1x9gknd 3784 21 is be VBZ cord-010119-t1x9gknd 3784 22 flow flow NN cord-010119-t1x9gknd 3784 23 cytometry cytometry NN cord-010119-t1x9gknd 3784 24 . . . cord-010119-t1x9gknd 3785 1 Alternative alternative JJ cord-010119-t1x9gknd 3785 2 technologies technology NNS cord-010119-t1x9gknd 3785 3 have have VBP cord-010119-t1x9gknd 3785 4 been be VBN cord-010119-t1x9gknd 3785 5 developed develop VBN cord-010119-t1x9gknd 3785 6 including include VBG cord-010119-t1x9gknd 3785 7 hemocytometry hemocytometry NNP cord-010119-t1x9gknd 3785 8 and and CC cord-010119-t1x9gknd 3785 9 microfluorometry microfluorometry NNP cord-010119-t1x9gknd 3785 10 . . . cord-010119-t1x9gknd 3786 1 Study Study NNP cord-010119-t1x9gknd 3786 2 Design Design NNP cord-010119-t1x9gknd 3786 3 / / SYM cord-010119-t1x9gknd 3786 4 Methods method NNS cord-010119-t1x9gknd 3786 5 : : : cord-010119-t1x9gknd 3787 1 This this DT cord-010119-t1x9gknd 3787 2 study study NN cord-010119-t1x9gknd 3787 3 compared compare VBD cord-010119-t1x9gknd 3787 4 performance performance NN cord-010119-t1x9gknd 3787 5 and and CC cord-010119-t1x9gknd 3787 6 workflow workflow NN cord-010119-t1x9gknd 3787 7 efficiency efficiency NN cord-010119-t1x9gknd 3787 8 of of IN cord-010119-t1x9gknd 3787 9 the the DT cord-010119-t1x9gknd 3787 10 FACSVia FACSVia NNP cord-010119-t1x9gknd 3787 11 , , , cord-010119-t1x9gknd 3787 12 a a DT cord-010119-t1x9gknd 3787 13 flow flow NN cord-010119-t1x9gknd 3787 14 cytometer cytometer NN cord-010119-t1x9gknd 3787 15 with with IN cord-010119-t1x9gknd 3787 16 a a DT cord-010119-t1x9gknd 3787 17 simplified simplified JJ cord-010119-t1x9gknd 3787 18 workflow workflow NN cord-010119-t1x9gknd 3787 19 and and CC cord-010119-t1x9gknd 3787 20 automated automate VBN cord-010119-t1x9gknd 3787 21 loader loader NN cord-010119-t1x9gknd 3787 22 to to IN cord-010119-t1x9gknd 3787 23 the the DT cord-010119-t1x9gknd 3787 24 ADAM ADAM NNP cord-010119-t1x9gknd 3787 25 automatic automatic JJ cord-010119-t1x9gknd 3787 26 microscopic microscopic JJ cord-010119-t1x9gknd 3787 27 cell cell NN cord-010119-t1x9gknd 3787 28 counter counter NN cord-010119-t1x9gknd 3787 29 based base VBN cord-010119-t1x9gknd 3787 30 on on IN cord-010119-t1x9gknd 3787 31 imaging image VBG cord-010119-t1x9gknd 3787 32 technology technology NN cord-010119-t1x9gknd 3787 33 . . . cord-010119-t1x9gknd 3788 1 Nonfiltered nonfiltered JJ cord-010119-t1x9gknd 3788 2 whole whole JJ cord-010119-t1x9gknd 3788 3 blood blood NN cord-010119-t1x9gknd 3788 4 ( ( -LRB- cord-010119-t1x9gknd 3788 5 WB WB NNP cord-010119-t1x9gknd 3788 6 ) ) -RRB- cord-010119-t1x9gknd 3788 7 samples sample NNS cord-010119-t1x9gknd 3788 8 , , , cord-010119-t1x9gknd 3788 9 apheresis apheresis NN cord-010119-t1x9gknd 3788 10 platelet platelet NN cord-010119-t1x9gknd 3788 11 units unit NNS cord-010119-t1x9gknd 3788 12 ( ( -LRB- cord-010119-t1x9gknd 3788 13 n52 n52 NNP cord-010119-t1x9gknd 3788 14 ) ) -RRB- cord-010119-t1x9gknd 3788 15 and and CC cord-010119-t1x9gknd 3788 16 leukoreduced leukoreduced NNP cord-010119-t1x9gknd 3788 17 ( ( -LRB- cord-010119-t1x9gknd 3788 18 LR LR NNP cord-010119-t1x9gknd 3788 19 ) ) -RRB- cord-010119-t1x9gknd 3788 20 RBC RBC NNP cord-010119-t1x9gknd 3788 21 units unit NNS cord-010119-t1x9gknd 3788 22 ( ( -LRB- cord-010119-t1x9gknd 3788 23 n52 n52 NNP cord-010119-t1x9gknd 3788 24 ) ) -RRB- cord-010119-t1x9gknd 3788 25 were be VBD cord-010119-t1x9gknd 3788 26 used use VBN cord-010119-t1x9gknd 3788 27 to to TO cord-010119-t1x9gknd 3788 28 generate generate VB cord-010119-t1x9gknd 3788 29 spiked spiked JJ cord-010119-t1x9gknd 3788 30 samples sample NNS cord-010119-t1x9gknd 3788 31 . . . cord-010119-t1x9gknd 3789 1 Apheresis Apheresis NNP cord-010119-t1x9gknd 3789 2 platelets platelet NNS cord-010119-t1x9gknd 3789 3 and and CC cord-010119-t1x9gknd 3789 4 LR LR NNP cord-010119-t1x9gknd 3789 5 RBC RBC NNP cord-010119-t1x9gknd 3789 6 were be VBD cord-010119-t1x9gknd 3789 7 filtered filter VBN cord-010119-t1x9gknd 3789 8 to to TO cord-010119-t1x9gknd 3789 9 deplete deplete VB cord-010119-t1x9gknd 3789 10 WBCs wbc NNS cord-010119-t1x9gknd 3789 11 and and CC cord-010119-t1x9gknd 3789 12 were be VBD cord-010119-t1x9gknd 3789 13 used use VBN cord-010119-t1x9gknd 3789 14 as as IN cord-010119-t1x9gknd 3789 15 a a DT cord-010119-t1x9gknd 3789 16 diluent diluent NN cord-010119-t1x9gknd 3789 17 . . . cord-010119-t1x9gknd 3790 1 Nonfiltered Nonfiltered NNP cord-010119-t1x9gknd 3790 2 WB WB NNP cord-010119-t1x9gknd 3790 3 samples sample NNS cord-010119-t1x9gknd 3790 4 were be VBD cord-010119-t1x9gknd 3790 5 the the DT cord-010119-t1x9gknd 3790 6 source source NN cord-010119-t1x9gknd 3790 7 of of IN cord-010119-t1x9gknd 3790 8 WBCs wbc NNS cord-010119-t1x9gknd 3790 9 to to TO cord-010119-t1x9gknd 3790 10 prepare prepare VB cord-010119-t1x9gknd 3790 11 a a DT cord-010119-t1x9gknd 3790 12 sample sample NN cord-010119-t1x9gknd 3790 13 of of IN cord-010119-t1x9gknd 3790 14 1000 1000 CD cord-010119-t1x9gknd 3790 15 WBC WBC NNP cord-010119-t1x9gknd 3790 16 / / SYM cord-010119-t1x9gknd 3790 17 uL. ul. NN cord-010119-t1x9gknd 3790 18 The the DT cord-010119-t1x9gknd 3790 19 spiked spiked JJ cord-010119-t1x9gknd 3790 20 samples sample NNS cord-010119-t1x9gknd 3790 21 of of IN cord-010119-t1x9gknd 3790 22 5 5 CD cord-010119-t1x9gknd 3790 23 , , , cord-010119-t1x9gknd 3790 24 12.5 12.5 CD cord-010119-t1x9gknd 3790 25 , , , cord-010119-t1x9gknd 3790 26 5 5 CD cord-010119-t1x9gknd 3790 27 , , , cord-010119-t1x9gknd 3790 28 25 25 CD cord-010119-t1x9gknd 3790 29 , , , cord-010119-t1x9gknd 3790 30 50 50 CD cord-010119-t1x9gknd 3790 31 and and CC cord-010119-t1x9gknd 3790 32 100 100 CD cord-010119-t1x9gknd 3790 33 WBC WBC NNP cord-010119-t1x9gknd 3790 34 / / SYM cord-010119-t1x9gknd 3790 35 uL uL NNP cord-010119-t1x9gknd 3790 36 were be VBD cord-010119-t1x9gknd 3790 37 prepared prepare VBN cord-010119-t1x9gknd 3790 38 from from IN cord-010119-t1x9gknd 3790 39 the the DT cord-010119-t1x9gknd 3790 40 source source NN cord-010119-t1x9gknd 3790 41 sample sample NN cord-010119-t1x9gknd 3790 42 of of IN cord-010119-t1x9gknd 3790 43 1000 1000 CD cord-010119-t1x9gknd 3790 44 WBC WBC NNP cord-010119-t1x9gknd 3790 45 / / SYM cord-010119-t1x9gknd 3790 46 uL ul NN cord-010119-t1x9gknd 3790 47 and and CC cord-010119-t1x9gknd 3790 48 filtered filter VBN cord-010119-t1x9gknd 3790 49 platelet platelet NN cord-010119-t1x9gknd 3790 50 and and CC cord-010119-t1x9gknd 3790 51 RBC RBC NNP cord-010119-t1x9gknd 3790 52 units unit NNS cord-010119-t1x9gknd 3790 53 . . . cord-010119-t1x9gknd 3791 1 To to TO cord-010119-t1x9gknd 3791 2 evaluate evaluate VB cord-010119-t1x9gknd 3791 3 linearity linearity NN cord-010119-t1x9gknd 3791 4 , , , cord-010119-t1x9gknd 3791 5 WBC WBC NNP cord-010119-t1x9gknd 3791 6 concentrations concentration NNS cord-010119-t1x9gknd 3791 7 ( ( -LRB- cord-010119-t1x9gknd 3791 8 0 0 CD cord-010119-t1x9gknd 3791 9 , , , cord-010119-t1x9gknd 3791 10 12.5 12.5 CD cord-010119-t1x9gknd 3791 11 , , , cord-010119-t1x9gknd 3791 12 5 5 CD cord-010119-t1x9gknd 3791 13 , , , cord-010119-t1x9gknd 3791 14 25 25 CD cord-010119-t1x9gknd 3791 15 , , , cord-010119-t1x9gknd 3791 16 50 50 CD cord-010119-t1x9gknd 3791 17 , , , cord-010119-t1x9gknd 3791 18 100 100 CD cord-010119-t1x9gknd 3791 19 WBC WBC NNP cord-010119-t1x9gknd 3791 20 / / SYM cord-010119-t1x9gknd 3791 21 uL uL NNP cord-010119-t1x9gknd 3791 22 ) ) -RRB- cord-010119-t1x9gknd 3791 23 were be VBD cord-010119-t1x9gknd 3791 24 measured measure VBN cord-010119-t1x9gknd 3791 25 using use VBG cord-010119-t1x9gknd 3791 26 ADAM ADAM NNP cord-010119-t1x9gknd 3791 27 and and CC cord-010119-t1x9gknd 3791 28 FACSVia FACSVia NNP cord-010119-t1x9gknd 3791 29 . . . cord-010119-t1x9gknd 3792 1 Samples sample NNS cord-010119-t1x9gknd 3792 2 were be VBD cord-010119-t1x9gknd 3792 3 stained stain VBN cord-010119-t1x9gknd 3792 4 and and CC cord-010119-t1x9gknd 3792 5 run run VBN cord-010119-t1x9gknd 3792 6 in in IN cord-010119-t1x9gknd 3792 7 triplicate triplicate NN cord-010119-t1x9gknd 3792 8 on on IN cord-010119-t1x9gknd 3792 9 each each DT cord-010119-t1x9gknd 3792 10 analyzer analyzer NN cord-010119-t1x9gknd 3792 11 . . . cord-010119-t1x9gknd 3793 1 Data datum NNS cord-010119-t1x9gknd 3793 2 was be VBD cord-010119-t1x9gknd 3793 3 analyzed analyze VBN cord-010119-t1x9gknd 3793 4 using use VBG cord-010119-t1x9gknd 3793 5 linear linear JJ cord-010119-t1x9gknd 3793 6 regression regression NN cord-010119-t1x9gknd 3793 7 . . . cord-010119-t1x9gknd 3794 1 The the DT cord-010119-t1x9gknd 3794 2 results result NNS cord-010119-t1x9gknd 3794 3 were be VBD cord-010119-t1x9gknd 3794 4 proportional proportional JJ cord-010119-t1x9gknd 3794 5 to to IN cord-010119-t1x9gknd 3794 6 the the DT cord-010119-t1x9gknd 3794 7 WBC WBC NNP cord-010119-t1x9gknd 3794 8 concentration concentration NN cord-010119-t1x9gknd 3794 9 in in IN cord-010119-t1x9gknd 3794 10 the the DT cord-010119-t1x9gknd 3794 11 spiked spiked JJ cord-010119-t1x9gknd 3794 12 samples sample NNS cord-010119-t1x9gknd 3794 13 . . . cord-010119-t1x9gknd 3795 1 Reproducibility reproducibility NN cord-010119-t1x9gknd 3795 2 of of IN cord-010119-t1x9gknd 3795 3 the the DT cord-010119-t1x9gknd 3795 4 two two CD cord-010119-t1x9gknd 3795 5 systems system NNS cord-010119-t1x9gknd 3795 6 was be VBD cord-010119-t1x9gknd 3795 7 measured measure VBN cord-010119-t1x9gknd 3795 8 by by IN cord-010119-t1x9gknd 3795 9 running run VBG cord-010119-t1x9gknd 3795 10 spiked spiked JJ cord-010119-t1x9gknd 3795 11 samples sample NNS cord-010119-t1x9gknd 3795 12 ( ( -LRB- cord-010119-t1x9gknd 3795 13 0 0 CD cord-010119-t1x9gknd 3795 14 , , , cord-010119-t1x9gknd 3795 15 5 5 CD cord-010119-t1x9gknd 3795 16 , , , cord-010119-t1x9gknd 3795 17 25 25 CD cord-010119-t1x9gknd 3795 18 , , , cord-010119-t1x9gknd 3795 19 50 50 CD cord-010119-t1x9gknd 3795 20 WBC WBC NNP cord-010119-t1x9gknd 3795 21 / / SYM cord-010119-t1x9gknd 3795 22 uL uL NNP cord-010119-t1x9gknd 3795 23 ) ) -RRB- cord-010119-t1x9gknd 3795 24 . . . cord-010119-t1x9gknd 3796 1 10 10 CD cord-010119-t1x9gknd 3796 2 tubes tube NNS cord-010119-t1x9gknd 3796 3 of of IN cord-010119-t1x9gknd 3796 4 each each DT cord-010119-t1x9gknd 3796 5 sample sample NN cord-010119-t1x9gknd 3796 6 were be VBD cord-010119-t1x9gknd 3796 7 stained stain VBN cord-010119-t1x9gknd 3796 8 and and CC cord-010119-t1x9gknd 3796 9 run run VBN cord-010119-t1x9gknd 3796 10 per per IN cord-010119-t1x9gknd 3796 11 system system NN cord-010119-t1x9gknd 3796 12 . . . cord-010119-t1x9gknd 3797 1 The the DT cord-010119-t1x9gknd 3797 2 % % NN cord-010119-t1x9gknd 3797 3 CV cv NN cord-010119-t1x9gknd 3797 4 and and CC cord-010119-t1x9gknd 3797 5 % % NN cord-010119-t1x9gknd 3797 6 Diff Diff NNP cord-010119-t1x9gknd 3797 7 were be VBD cord-010119-t1x9gknd 3797 8 calculated calculate VBN cord-010119-t1x9gknd 3797 9 . . . cord-010119-t1x9gknd 3798 1 A a DT cord-010119-t1x9gknd 3798 2 batch batch NN cord-010119-t1x9gknd 3798 3 of of IN cord-010119-t1x9gknd 3798 4 20 20 CD cord-010119-t1x9gknd 3798 5 samples sample NNS cord-010119-t1x9gknd 3798 6 ( ( -LRB- cord-010119-t1x9gknd 3798 7 PLT PLT NNP cord-010119-t1x9gknd 3798 8 and and CC cord-010119-t1x9gknd 3798 9 RBC RBC NNP cord-010119-t1x9gknd 3798 10 ) ) -RRB- cord-010119-t1x9gknd 3798 11 were be VBD cord-010119-t1x9gknd 3798 12 run run VBN cord-010119-t1x9gknd 3798 13 on on IN cord-010119-t1x9gknd 3798 14 both both DT cord-010119-t1x9gknd 3798 15 analyzers analyzer NNS cord-010119-t1x9gknd 3798 16 , , , cord-010119-t1x9gknd 3798 17 repeated repeat VBN cord-010119-t1x9gknd 3798 18 for for IN cord-010119-t1x9gknd 3798 19 5 5 CD cord-010119-t1x9gknd 3798 20 days day NNS cord-010119-t1x9gknd 3798 21 . . . cord-010119-t1x9gknd 3799 1 Workflow workflow NN cord-010119-t1x9gknd 3799 2 efficiency efficiency NN cord-010119-t1x9gknd 3799 3 was be VBD cord-010119-t1x9gknd 3799 4 assessed assess VBN cord-010119-t1x9gknd 3799 5 observationally observationally RB cord-010119-t1x9gknd 3799 6 by by IN cord-010119-t1x9gknd 3799 7 measuring measure VBG cord-010119-t1x9gknd 3799 8 the the DT cord-010119-t1x9gknd 3799 9 time time NN cord-010119-t1x9gknd 3799 10 of of IN cord-010119-t1x9gknd 3799 11 tasks task NNS cord-010119-t1x9gknd 3799 12 performed perform VBN cord-010119-t1x9gknd 3799 13 . . . cord-010119-t1x9gknd 3800 1 Tasks task NNS cord-010119-t1x9gknd 3800 2 recorded record VBN cord-010119-t1x9gknd 3800 3 were be VBD cord-010119-t1x9gknd 3800 4 Instrument Instrument NNP cord-010119-t1x9gknd 3800 5 QC QC NNP cord-010119-t1x9gknd 3800 6 , , , cord-010119-t1x9gknd 3800 7 assay assay NN cord-010119-t1x9gknd 3800 8 controls control NNS cord-010119-t1x9gknd 3800 9 and and CC cord-010119-t1x9gknd 3800 10 sample sample NN cord-010119-t1x9gknd 3800 11 testing testing NN cord-010119-t1x9gknd 3800 12 and and CC cord-010119-t1x9gknd 3800 13 analysis analysis NN cord-010119-t1x9gknd 3800 14 . . . cord-010119-t1x9gknd 3801 1 Results result NNS cord-010119-t1x9gknd 3801 2 / / SYM cord-010119-t1x9gknd 3801 3 Findings finding NNS cord-010119-t1x9gknd 3801 4 : : : cord-010119-t1x9gknd 3802 1 The the DT cord-010119-t1x9gknd 3802 2 WBC WBC NNP cord-010119-t1x9gknd 3802 3 concentration concentration NN cord-010119-t1x9gknd 3802 4 results result NNS cord-010119-t1x9gknd 3802 5 for for IN cord-010119-t1x9gknd 3802 6 PLT PLT NNP cord-010119-t1x9gknd 3802 7 and and CC cord-010119-t1x9gknd 3802 8 RBC RBC NNP cord-010119-t1x9gknd 3802 9 samples sample NNS cord-010119-t1x9gknd 3802 10 on on IN cord-010119-t1x9gknd 3802 11 FACSVia FACSVia NNP cord-010119-t1x9gknd 3802 12 correlated correlate VBN cord-010119-t1x9gknd 3802 13 well well RB cord-010119-t1x9gknd 3802 14 with with IN cord-010119-t1x9gknd 3802 15 ADAM ADAM NNP cord-010119-t1x9gknd 3802 16 ( ( -LRB- cord-010119-t1x9gknd 3802 17 r r NN cord-010119-t1x9gknd 3802 18 - - : cord-010119-t1x9gknd 3802 19 PLT50.996 PLT50.996 NNP cord-010119-t1x9gknd 3802 20 , , , cord-010119-t1x9gknd 3802 21 slope50.972 slope50.972 NNP cord-010119-t1x9gknd 3802 22 ) ) -RRB- cord-010119-t1x9gknd 3802 23 , , , cord-010119-t1x9gknd 3802 24 ( ( -LRB- cord-010119-t1x9gknd 3802 25 r r NN cord-010119-t1x9gknd 3802 26 - - : cord-010119-t1x9gknd 3802 27 RBC50.999 RBC50.999 NNP cord-010119-t1x9gknd 3802 28 , , , cord-010119-t1x9gknd 3802 29 slope50.992 slope50.992 NNP cord-010119-t1x9gknd 3802 30 ) ) -RRB- cord-010119-t1x9gknd 3802 31 . . . cord-010119-t1x9gknd 3803 1 The the DT cord-010119-t1x9gknd 3803 2 % % NN cord-010119-t1x9gknd 3803 3 Diff Diff NNP cord-010119-t1x9gknd 3803 4 - - HYPH cord-010119-t1x9gknd 3803 5 PLT PLT NNP cord-010119-t1x9gknd 3803 6 at at IN cord-010119-t1x9gknd 3803 7 5 5 CD cord-010119-t1x9gknd 3803 8 , , , cord-010119-t1x9gknd 3803 9 25 25 CD cord-010119-t1x9gknd 3803 10 , , , cord-010119-t1x9gknd 3803 11 50 50 CD cord-010119-t1x9gknd 3803 12 WBC WBC NNP cord-010119-t1x9gknd 3803 13 / / SYM cord-010119-t1x9gknd 3803 14 uL uL NNP cord-010119-t1x9gknd 3803 15 were be VBD cord-010119-t1x9gknd 3803 16 7.8 7.8 CD cord-010119-t1x9gknd 3803 17 , , , cord-010119-t1x9gknd 3803 18 4.7 4.7 CD cord-010119-t1x9gknd 3803 19 and and CC cord-010119-t1x9gknd 3803 20 10 10 CD cord-010119-t1x9gknd 3803 21 , , , cord-010119-t1x9gknd 3803 22 respectively respectively RB cord-010119-t1x9gknd 3803 23 . . . cord-010119-t1x9gknd 3804 1 The the DT cord-010119-t1x9gknd 3804 2 % % NN cord-010119-t1x9gknd 3804 3 Diff Diff NNP cord-010119-t1x9gknd 3804 4 - - HYPH cord-010119-t1x9gknd 3804 5 RBC RBC NNP cord-010119-t1x9gknd 3804 6 at at IN cord-010119-t1x9gknd 3804 7 5 5 CD cord-010119-t1x9gknd 3804 8 , , , cord-010119-t1x9gknd 3804 9 25 25 CD cord-010119-t1x9gknd 3804 10 , , , cord-010119-t1x9gknd 3804 11 50 50 CD cord-010119-t1x9gknd 3804 12 WBC WBC NNP cord-010119-t1x9gknd 3804 13 / / SYM cord-010119-t1x9gknd 3804 14 uL uL NNP cord-010119-t1x9gknd 3804 15 were be VBD cord-010119-t1x9gknd 3804 16 10.8 10.8 CD cord-010119-t1x9gknd 3804 17 , , , cord-010119-t1x9gknd 3804 18 3.2 3.2 CD cord-010119-t1x9gknd 3804 19 and and CC cord-010119-t1x9gknd 3804 20 14.7 14.7 CD cord-010119-t1x9gknd 3804 21 , , , cord-010119-t1x9gknd 3804 22 respectively respectively RB cord-010119-t1x9gknd 3804 23 . . . cord-010119-t1x9gknd 3805 1 The the DT cord-010119-t1x9gknd 3805 2 average average JJ cord-010119-t1x9gknd 3805 3 total total JJ cord-010119-t1x9gknd 3805 4 testing testing NN cord-010119-t1x9gknd 3805 5 time time NN cord-010119-t1x9gknd 3805 6 was be VBD cord-010119-t1x9gknd 3805 7 similar similar JJ cord-010119-t1x9gknd 3805 8 on on IN cord-010119-t1x9gknd 3805 9 both both DT cord-010119-t1x9gknd 3805 10 instruments instrument NNS cord-010119-t1x9gknd 3805 11 ; ; : cord-010119-t1x9gknd 3805 12 89 89 CD cord-010119-t1x9gknd 3805 13 min min NN cord-010119-t1x9gknd 3805 14 for for IN cord-010119-t1x9gknd 3805 15 the the DT cord-010119-t1x9gknd 3805 16 FACSVia FACSVia NNP cord-010119-t1x9gknd 3805 17 and and CC cord-010119-t1x9gknd 3805 18 92 92 CD cord-010119-t1x9gknd 3805 19 min min NN cord-010119-t1x9gknd 3805 20 for for IN cord-010119-t1x9gknd 3805 21 the the DT cord-010119-t1x9gknd 3805 22 ADAM ADAM NNP cord-010119-t1x9gknd 3805 23 . . . cord-010119-t1x9gknd 3806 1 Of of IN cord-010119-t1x9gknd 3806 2 the the DT cord-010119-t1x9gknd 3806 3 total total JJ cord-010119-t1x9gknd 3806 4 testing testing NN cord-010119-t1x9gknd 3806 5 time time NN cord-010119-t1x9gknd 3806 6 , , , cord-010119-t1x9gknd 3806 7 ADAM ADAM NNP cord-010119-t1x9gknd 3806 8 required require VBD cord-010119-t1x9gknd 3806 9 continuous continuous JJ cord-010119-t1x9gknd 3806 10 hands hand NNS cord-010119-t1x9gknd 3806 11 - - HYPH cord-010119-t1x9gknd 3806 12 on on RP cord-010119-t1x9gknd 3806 13 time time NN cord-010119-t1x9gknd 3806 14 , , , cord-010119-t1x9gknd 3806 15 while while IN cord-010119-t1x9gknd 3806 16 FACSVia FACSVia NNP cord-010119-t1x9gknd 3806 17 demonstrated demonstrate VBD cord-010119-t1x9gknd 3806 18 62 62 CD cord-010119-t1x9gknd 3806 19 % % NN cord-010119-t1x9gknd 3806 20 ( ( -LRB- cord-010119-t1x9gknd 3806 21 56 56 CD cord-010119-t1x9gknd 3806 22 of of IN cord-010119-t1x9gknd 3806 23 89 89 CD cord-010119-t1x9gknd 3806 24 min min NN cord-010119-t1x9gknd 3806 25 ) ) -RRB- cord-010119-t1x9gknd 3806 26 hands hand NNS cord-010119-t1x9gknd 3806 27 - - HYPH cord-010119-t1x9gknd 3806 28 off off RP cord-010119-t1x9gknd 3806 29 time time NN cord-010119-t1x9gknd 3806 30 . . . cord-010119-t1x9gknd 3807 1 Conclusion conclusion NN cord-010119-t1x9gknd 3807 2 : : : cord-010119-t1x9gknd 3808 1 Both both DT cord-010119-t1x9gknd 3808 2 instruments instrument NNS cord-010119-t1x9gknd 3808 3 showed show VBD cord-010119-t1x9gknd 3808 4 comparable comparable JJ cord-010119-t1x9gknd 3808 5 precision precision NN cord-010119-t1x9gknd 3808 6 , , , cord-010119-t1x9gknd 3808 7 linearity linearity NN cord-010119-t1x9gknd 3808 8 and and CC cord-010119-t1x9gknd 3808 9 accuracy accuracy NN cord-010119-t1x9gknd 3808 10 . . . cord-010119-t1x9gknd 3809 1 While while IN cord-010119-t1x9gknd 3809 2 the the DT cord-010119-t1x9gknd 3809 3 average average JJ cord-010119-t1x9gknd 3809 4 total total JJ cord-010119-t1x9gknd 3809 5 testing testing NN cord-010119-t1x9gknd 3809 6 time time NN cord-010119-t1x9gknd 3809 7 was be VBD cord-010119-t1x9gknd 3809 8 similar similar JJ cord-010119-t1x9gknd 3809 9 on on IN cord-010119-t1x9gknd 3809 10 both both DT cord-010119-t1x9gknd 3809 11 instruments instrument NNS cord-010119-t1x9gknd 3809 12 , , , cord-010119-t1x9gknd 3809 13 FACSVia FACSVia NNP cord-010119-t1x9gknd 3809 14 offered offer VBD cord-010119-t1x9gknd 3809 15 a a DT cord-010119-t1x9gknd 3809 16 significant significant JJ cord-010119-t1x9gknd 3809 17 workflow workflow NN cord-010119-t1x9gknd 3809 18 efficiency efficiency NN cord-010119-t1x9gknd 3809 19 advantage advantage NN cord-010119-t1x9gknd 3809 20 . . . cord-010119-t1x9gknd 3810 1 Users user NNS cord-010119-t1x9gknd 3810 2 saved save VBD cord-010119-t1x9gknd 3810 3 an an DT cord-010119-t1x9gknd 3810 4 average average JJ cord-010119-t1x9gknd 3810 5 hands hand NNS cord-010119-t1x9gknd 3810 6 - - HYPH cord-010119-t1x9gknd 3810 7 on on RP cord-010119-t1x9gknd 3810 8 time time NN cord-010119-t1x9gknd 3810 9 of of IN cord-010119-t1x9gknd 3810 10 56 56 CD cord-010119-t1x9gknd 3810 11 minutes minute NNS cord-010119-t1x9gknd 3810 12 that that WDT cord-010119-t1x9gknd 3810 13 could could MD cord-010119-t1x9gknd 3810 14 be be VB cord-010119-t1x9gknd 3810 15 used use VBN cord-010119-t1x9gknd 3810 16 on on IN cord-010119-t1x9gknd 3810 17 other other JJ cord-010119-t1x9gknd 3810 18 tasks task NNS cord-010119-t1x9gknd 3810 19 . . . cord-010119-t1x9gknd 3811 1 Platelet platelet NN cord-010119-t1x9gknd 3811 2 Rich Rich NNP cord-010119-t1x9gknd 3811 3 Plasma Plasma NNP cord-010119-t1x9gknd 3811 4 and and CC cord-010119-t1x9gknd 3811 5 Quality Quality NNP cord-010119-t1x9gknd 3811 6 Control Control NNP cord-010119-t1x9gknd 3811 7 : : : cord-010119-t1x9gknd 3811 8 Is be VBZ cord-010119-t1x9gknd 3811 9 There there EX cord-010119-t1x9gknd 3811 10 a a DT cord-010119-t1x9gknd 3811 11 Role role NN cord-010119-t1x9gknd 3811 12 for for IN cord-010119-t1x9gknd 3811 13 the the DT cord-010119-t1x9gknd 3811 14 Blood Blood NNP cord-010119-t1x9gknd 3811 15 Bank Bank NNP cord-010119-t1x9gknd 3811 16 ? ? . cord-010119-t1x9gknd 3812 1 Claudia Claudia NNP cord-010119-t1x9gknd 3812 2 S. S. NNP cord-010119-t1x9gknd 3812 3 Cohn Cohn NNP cord-010119-t1x9gknd 3812 4 * * NFP cord-010119-t1x9gknd 3813 1 1 1 CD cord-010119-t1x9gknd 3813 2 and and CC cord-010119-t1x9gknd 3813 3 Mickey Mickey NNP cord-010119-t1x9gknd 3813 4 Koh Koh NNP cord-010119-t1x9gknd 3814 1 2 2 LS cord-010119-t1x9gknd 3814 2 . . . cord-010119-t1x9gknd 3814 3 1 1 CD cord-010119-t1x9gknd 3814 4 Department Department NNP cord-010119-t1x9gknd 3814 5 of of IN cord-010119-t1x9gknd 3814 6 Laboratory Laboratory NNP cord-010119-t1x9gknd 3814 7 Medicine Medicine NNP cord-010119-t1x9gknd 3814 8 and and CC cord-010119-t1x9gknd 3814 9 Pathology Pathology NNP cord-010119-t1x9gknd 3814 10 , , , cord-010119-t1x9gknd 3814 11 University University NNP cord-010119-t1x9gknd 3814 12 of of IN cord-010119-t1x9gknd 3814 13 Minnesota Minnesota NNP cord-010119-t1x9gknd 3814 14 , , , cord-010119-t1x9gknd 3814 15 2 2 CD cord-010119-t1x9gknd 3814 16 St St NNP cord-010119-t1x9gknd 3814 17 George George NNP cord-010119-t1x9gknd 3814 18 's 's POS cord-010119-t1x9gknd 3814 19 Hospital Hospital NNP cord-010119-t1x9gknd 3814 20 and and CC cord-010119-t1x9gknd 3814 21 Medical Medical NNP cord-010119-t1x9gknd 3814 22 School School NNP cord-010119-t1x9gknd 3814 23 Background Background NNP cord-010119-t1x9gknd 3814 24 / / SYM cord-010119-t1x9gknd 3814 25 Case Case NNP cord-010119-t1x9gknd 3814 26 Studies Studies NNPS cord-010119-t1x9gknd 3814 27 : : : cord-010119-t1x9gknd 3814 28 Autologous autologous JJ cord-010119-t1x9gknd 3814 29 Platelet platelet NN cord-010119-t1x9gknd 3814 30 - - HYPH cord-010119-t1x9gknd 3814 31 rich rich JJ cord-010119-t1x9gknd 3814 32 plasma plasma NN cord-010119-t1x9gknd 3814 33 ( ( -LRB- cord-010119-t1x9gknd 3814 34 aPRP aPRP NNP cord-010119-t1x9gknd 3814 35 ) ) -RRB- cord-010119-t1x9gknd 3814 36 is be VBZ cord-010119-t1x9gknd 3814 37 a a DT cord-010119-t1x9gknd 3814 38 poorly poorly RB cord-010119-t1x9gknd 3814 39 regulated regulate VBN cord-010119-t1x9gknd 3814 40 blood blood NN cord-010119-t1x9gknd 3814 41 component component NN cord-010119-t1x9gknd 3814 42 often often RB cord-010119-t1x9gknd 3814 43 produced produce VBN cord-010119-t1x9gknd 3814 44 at at IN cord-010119-t1x9gknd 3814 45 the the DT cord-010119-t1x9gknd 3814 46 patient patient NN cord-010119-t1x9gknd 3814 47 's 's POS cord-010119-t1x9gknd 3814 48 bedside bedside NN cord-010119-t1x9gknd 3814 49 and and CC cord-010119-t1x9gknd 3814 50 used use VBD cord-010119-t1x9gknd 3814 51 for for IN cord-010119-t1x9gknd 3814 52 indications indication NNS cord-010119-t1x9gknd 3814 53 such such JJ cord-010119-t1x9gknd 3814 54 as as IN cord-010119-t1x9gknd 3814 55 chronic chronic JJ cord-010119-t1x9gknd 3814 56 and and CC cord-010119-t1x9gknd 3814 57 acute acute JJ cord-010119-t1x9gknd 3814 58 orthopedic orthopedic JJ cord-010119-t1x9gknd 3814 59 injuries injury NNS cord-010119-t1x9gknd 3814 60 , , , cord-010119-t1x9gknd 3814 61 wound wound NN cord-010119-t1x9gknd 3814 62 and and CC cord-010119-t1x9gknd 3814 63 incision incision NN cord-010119-t1x9gknd 3814 64 - - HYPH cord-010119-t1x9gknd 3814 65 healing healing NN cord-010119-t1x9gknd 3814 66 and and CC cord-010119-t1x9gknd 3814 67 rheumatologic rheumatologic JJ cord-010119-t1x9gknd 3814 68 diseases disease NNS cord-010119-t1x9gknd 3814 69 . . . cord-010119-t1x9gknd 3815 1 PRP prp NN cord-010119-t1x9gknd 3815 2 isolation isolation NN cord-010119-t1x9gknd 3815 3 can can MD cord-010119-t1x9gknd 3815 4 be be VB cord-010119-t1x9gknd 3815 5 done do VBN cord-010119-t1x9gknd 3815 6 by by IN cord-010119-t1x9gknd 3815 7 apheresis apheresis NN cord-010119-t1x9gknd 3815 8 , , , cord-010119-t1x9gknd 3815 9 which which WDT cord-010119-t1x9gknd 3815 10 yields yield VBZ cord-010119-t1x9gknd 3815 11 a a DT cord-010119-t1x9gknd 3815 12 consistent consistent JJ cord-010119-t1x9gknd 3815 13 , , , cord-010119-t1x9gknd 3815 14 platelet platelet NN cord-010119-t1x9gknd 3815 15 - - HYPH cord-010119-t1x9gknd 3815 16 rich rich JJ cord-010119-t1x9gknd 3815 17 fraction fraction NN cord-010119-t1x9gknd 3815 18 ; ; : cord-010119-t1x9gknd 3815 19 however however RB cord-010119-t1x9gknd 3815 20 , , , cord-010119-t1x9gknd 3815 21 most most JJS cord-010119-t1x9gknd 3815 22 aPRP aPRP , cord-010119-t1x9gknd 3815 23 is be VBZ cord-010119-t1x9gknd 3815 24 made make VBN cord-010119-t1x9gknd 3815 25 using use VBG cord-010119-t1x9gknd 3815 26 small small JJ cord-010119-t1x9gknd 3815 27 bench bench NN cord-010119-t1x9gknd 3815 28 - - HYPH cord-010119-t1x9gknd 3815 29 top top NN cord-010119-t1x9gknd 3815 30 centrifuges centrifuge NNS cord-010119-t1x9gknd 3815 31 with with IN cord-010119-t1x9gknd 3815 32 cartridges cartridge NNS cord-010119-t1x9gknd 3815 33 that that WDT cord-010119-t1x9gknd 3815 34 deliver deliver VBP cord-010119-t1x9gknd 3815 35 uneven uneven JJ cord-010119-t1x9gknd 3815 36 platelet platelet NN cord-010119-t1x9gknd 3815 37 enrichment enrichment NN cord-010119-t1x9gknd 3815 38 . . . cord-010119-t1x9gknd 3816 1 Thus thus RB cord-010119-t1x9gknd 3816 2 , , , cord-010119-t1x9gknd 3816 3 the the DT cord-010119-t1x9gknd 3816 4 consistency consistency NN cord-010119-t1x9gknd 3816 5 and and CC cord-010119-t1x9gknd 3816 6 quality quality NN cord-010119-t1x9gknd 3816 7 of of IN cord-010119-t1x9gknd 3816 8 aPRP aPRP NNP cord-010119-t1x9gknd 3816 9 is be VBZ cord-010119-t1x9gknd 3816 10 questionable questionable JJ cord-010119-t1x9gknd 3816 11 and and CC cord-010119-t1x9gknd 3816 12 the the DT cord-010119-t1x9gknd 3816 13 lower lower RBR cord-010119-t1x9gknd 3816 14 yielding yield VBG cord-010119-t1x9gknd 3816 15 PRP prp NN cord-010119-t1x9gknd 3816 16 may may MD cord-010119-t1x9gknd 3816 17 have have VB cord-010119-t1x9gknd 3816 18 decreased decrease VBN cord-010119-t1x9gknd 3816 19 efficacy efficacy NN cord-010119-t1x9gknd 3816 20 . . . cord-010119-t1x9gknd 3817 1 Study Study NNP cord-010119-t1x9gknd 3817 2 Design Design NNP cord-010119-t1x9gknd 3817 3 / / SYM cord-010119-t1x9gknd 3817 4 Methods method NNS cord-010119-t1x9gknd 3817 5 : : : cord-010119-t1x9gknd 3817 6 A a DT cord-010119-t1x9gknd 3817 7 survey survey NN cord-010119-t1x9gknd 3817 8 was be VBD cord-010119-t1x9gknd 3817 9 designed design VBN cord-010119-t1x9gknd 3817 10 to to TO cord-010119-t1x9gknd 3817 11 assess assess VB cord-010119-t1x9gknd 3817 12 aPRP aPRP `` cord-010119-t1x9gknd 3817 13 manufacture manufacture NN cord-010119-t1x9gknd 3817 14 , , , cord-010119-t1x9gknd 3817 15 usage usage NN cord-010119-t1x9gknd 3817 16 and and CC cord-010119-t1x9gknd 3817 17 quality quality NN cord-010119-t1x9gknd 3817 18 control control NN cord-010119-t1x9gknd 3817 19 ( ( -LRB- cord-010119-t1x9gknd 3817 20 QC QC NNP cord-010119-t1x9gknd 3817 21 ) ) -RRB- cord-010119-t1x9gknd 3817 22 measures measure NNS cord-010119-t1x9gknd 3817 23 taken take VBN cord-010119-t1x9gknd 3817 24 prior prior RB cord-010119-t1x9gknd 3817 25 to to IN cord-010119-t1x9gknd 3817 26 its -PRON- PRP$ cord-010119-t1x9gknd 3817 27 use use NN cord-010119-t1x9gknd 3817 28 . . . cord-010119-t1x9gknd 3818 1 A a DT cord-010119-t1x9gknd 3818 2 survey survey NN cord-010119-t1x9gknd 3818 3 was be VBD cord-010119-t1x9gknd 3818 4 developed develop VBN cord-010119-t1x9gknd 3818 5 with with IN cord-010119-t1x9gknd 3818 6 input input NN cord-010119-t1x9gknd 3818 7 from from IN cord-010119-t1x9gknd 3818 8 content content NN cord-010119-t1x9gknd 3818 9 experts expert NNS cord-010119-t1x9gknd 3818 10 . . . cord-010119-t1x9gknd 3819 1 The the DT cord-010119-t1x9gknd 3819 2 survey survey NN cord-010119-t1x9gknd 3819 3 was be VBD cord-010119-t1x9gknd 3819 4 sent send VBN cord-010119-t1x9gknd 3819 5 to to IN cord-010119-t1x9gknd 3819 6 members member NNS cord-010119-t1x9gknd 3819 7 of of IN cord-010119-t1x9gknd 3819 8 BEST best JJ cord-010119-t1x9gknd 3819 9 and and CC cord-010119-t1x9gknd 3819 10 ISBT ISBT NNP cord-010119-t1x9gknd 3819 11 . . . cord-010119-t1x9gknd 3820 1 Survey survey NN cord-010119-t1x9gknd 3820 2 respondents respondent NNS cord-010119-t1x9gknd 3820 3 were be VBD cord-010119-t1x9gknd 3820 4 encouraged encourage VBN cord-010119-t1x9gknd 3820 5 to to TO cord-010119-t1x9gknd 3820 6 forward forward VB cord-010119-t1x9gknd 3820 7 the the DT cord-010119-t1x9gknd 3820 8 survey survey NN cord-010119-t1x9gknd 3820 9 to to IN cord-010119-t1x9gknd 3820 10 colleagues colleague NNS cord-010119-t1x9gknd 3820 11 , , , cord-010119-t1x9gknd 3820 12 thus thus RB cord-010119-t1x9gknd 3820 13 a a DT cord-010119-t1x9gknd 3820 14 true true JJ cord-010119-t1x9gknd 3820 15 denominator denominator NN cord-010119-t1x9gknd 3820 16 is be VBZ cord-010119-t1x9gknd 3820 17 unknown unknown JJ cord-010119-t1x9gknd 3820 18 . . . cord-010119-t1x9gknd 3821 1 A a DT cord-010119-t1x9gknd 3821 2 total total NN cord-010119-t1x9gknd 3821 3 of of IN cord-010119-t1x9gknd 3821 4 62 62 CD cord-010119-t1x9gknd 3821 5 completed complete VBN cord-010119-t1x9gknd 3821 6 and and CC cord-010119-t1x9gknd 3821 7 partially partially RB cord-010119-t1x9gknd 3821 8 completed complete VBN cord-010119-t1x9gknd 3821 9 surveys survey NNS cord-010119-t1x9gknd 3821 10 were be VBD cord-010119-t1x9gknd 3821 11 received receive VBN cord-010119-t1x9gknd 3821 12 . . . cord-010119-t1x9gknd 3822 1 Results/ Results/ . cord-010119-t1x9gknd 3823 1 Findings finding NNS cord-010119-t1x9gknd 3823 2 : : : cord-010119-t1x9gknd 3824 1 Responses response NNS cord-010119-t1x9gknd 3824 2 came come VBD cord-010119-t1x9gknd 3824 3 from from IN cord-010119-t1x9gknd 3824 4 13 13 CD cord-010119-t1x9gknd 3824 5 countries country NNS cord-010119-t1x9gknd 3824 6 , , , cord-010119-t1x9gknd 3824 7 but but CC cord-010119-t1x9gknd 3824 8 the the DT cord-010119-t1x9gknd 3824 9 majority majority NN cord-010119-t1x9gknd 3824 10 of of IN cord-010119-t1x9gknd 3824 11 responses response NNS cord-010119-t1x9gknd 3824 12 came come VBD cord-010119-t1x9gknd 3824 13 from from IN cord-010119-t1x9gknd 3824 14 the the DT cord-010119-t1x9gknd 3824 15 United United NNP cord-010119-t1x9gknd 3824 16 States States NNP cord-010119-t1x9gknd 3824 17 ( ( -LRB- cord-010119-t1x9gknd 3824 18 US US NNP cord-010119-t1x9gknd 3824 19 ) ) -RRB- cord-010119-t1x9gknd 3824 20 . . . cord-010119-t1x9gknd 3825 1 Of of IN cord-010119-t1x9gknd 3825 2 the the DT cord-010119-t1x9gknd 3825 3 respondents respondent NNS cord-010119-t1x9gknd 3825 4 , , , cord-010119-t1x9gknd 3825 5 35 35 CD cord-010119-t1x9gknd 3825 6 % % NN cord-010119-t1x9gknd 3825 7 reported report VBN cord-010119-t1x9gknd 3825 8 aPRP aPRP , cord-010119-t1x9gknd 3825 9 use use NN cord-010119-t1x9gknd 3825 10 in in IN cord-010119-t1x9gknd 3825 11 their -PRON- PRP$ cord-010119-t1x9gknd 3825 12 hospital hospital NN cord-010119-t1x9gknd 3825 13 . . . cord-010119-t1x9gknd 3826 1 aPRP aPRP NNP cord-010119-t1x9gknd 3826 2 was be VBD cord-010119-t1x9gknd 3826 3 used use VBN cord-010119-t1x9gknd 3826 4 predominantly predominantly RB cord-010119-t1x9gknd 3826 5 for for IN cord-010119-t1x9gknd 3826 6 outpatients outpatient NNS cord-010119-t1x9gknd 3826 7 , , , cord-010119-t1x9gknd 3826 8 though though RB cord-010119-t1x9gknd 3826 9 > > XX cord-010119-t1x9gknd 3826 10 40 40 CD cord-010119-t1x9gknd 3826 11 % % NN cord-010119-t1x9gknd 3826 12 of of IN cord-010119-t1x9gknd 3826 13 hospitals hospital NNS cord-010119-t1x9gknd 3826 14 also also RB cord-010119-t1x9gknd 3826 15 used use VBD cord-010119-t1x9gknd 3826 16 aPRP aPRP '' cord-010119-t1x9gknd 3826 17 in in IN cord-010119-t1x9gknd 3826 18 the the DT cord-010119-t1x9gknd 3826 19 in in IN cord-010119-t1x9gknd 3826 20 - - HYPH cord-010119-t1x9gknd 3826 21 patient patient NN cord-010119-t1x9gknd 3826 22 setting setting NN cord-010119-t1x9gknd 3826 23 . . . cord-010119-t1x9gknd 3827 1 In in IN cord-010119-t1x9gknd 3827 2 most most JJS cord-010119-t1x9gknd 3827 3 hospitals hospital NNS cord-010119-t1x9gknd 3827 4 , , , cord-010119-t1x9gknd 3827 5 aPRP aPRP NNP cord-010119-t1x9gknd 3827 6 was be VBD cord-010119-t1x9gknd 3827 7 used use VBN cord-010119-t1x9gknd 3827 8 by by IN cord-010119-t1x9gknd 3827 9 1 1 CD cord-010119-t1x9gknd 3827 10 - - SYM cord-010119-t1x9gknd 3827 11 5 5 CD cord-010119-t1x9gknd 3827 12 MDs md NNS cord-010119-t1x9gknd 3827 13 ; ; : cord-010119-t1x9gknd 3827 14 however however RB cord-010119-t1x9gknd 3827 15 , , , cord-010119-t1x9gknd 3827 16 3 3 CD cord-010119-t1x9gknd 3827 17 hospitals hospital NNS cord-010119-t1x9gknd 3827 18 had have VBD cord-010119-t1x9gknd 3827 19 > > $ cord-010119-t1x9gknd 3827 20 10 10 CD cord-010119-t1x9gknd 3827 21 MDs md NNS cord-010119-t1x9gknd 3827 22 using use VBG cord-010119-t1x9gknd 3827 23 aPRP aPRP '' cord-010119-t1x9gknd 3827 24 . . . cord-010119-t1x9gknd 3828 1 The the DT cord-010119-t1x9gknd 3828 2 aPRP aPRP NNP cord-010119-t1x9gknd 3828 3 was be VBD cord-010119-t1x9gknd 3828 4 used use VBN cord-010119-t1x9gknd 3828 5 for for IN cord-010119-t1x9gknd 3828 6 orthopedics orthopedic NNS cord-010119-t1x9gknd 3828 7 , , , cord-010119-t1x9gknd 3828 8 wound wound NN cord-010119-t1x9gknd 3828 9 / / SYM cord-010119-t1x9gknd 3828 10 incision incision NN cord-010119-t1x9gknd 3828 11 repair repair NN cord-010119-t1x9gknd 3828 12 , , , cord-010119-t1x9gknd 3828 13 rheumatology rheumatology NN cord-010119-t1x9gknd 3828 14 and and CC cord-010119-t1x9gknd 3828 15 other other JJ cord-010119-t1x9gknd 3828 16 indications indication NNS cord-010119-t1x9gknd 3828 17 . . . cord-010119-t1x9gknd 3829 1 In in IN cord-010119-t1x9gknd 3829 2 the the DT cord-010119-t1x9gknd 3829 3 US US NNP cord-010119-t1x9gknd 3829 4 the the DT cord-010119-t1x9gknd 3829 5 aPRP aprp NN cord-010119-t1x9gknd 3829 6 was be VBD cord-010119-t1x9gknd 3829 7 manufactured manufacture VBN cord-010119-t1x9gknd 3829 8 outside outside RB cord-010119-t1x9gknd 3829 9 of of IN cord-010119-t1x9gknd 3829 10 the the DT cord-010119-t1x9gknd 3829 11 blood blood NN cord-010119-t1x9gknd 3829 12 bank bank NN cord-010119-t1x9gknd 3829 13 , , , cord-010119-t1x9gknd 3829 14 while while IN cord-010119-t1x9gknd 3829 15 outside outside IN cord-010119-t1x9gknd 3829 16 the the DT cord-010119-t1x9gknd 3829 17 US US NNP cord-010119-t1x9gknd 3829 18 aPRP aPRP `` cord-010119-t1x9gknd 3829 19 was be VBD cord-010119-t1x9gknd 3829 20 isolated isolate VBN cord-010119-t1x9gknd 3829 21 by by IN cord-010119-t1x9gknd 3829 22 blood blood NN cord-010119-t1x9gknd 3829 23 bank bank NN cord-010119-t1x9gknd 3829 24 personnel personnel NNS cord-010119-t1x9gknd 3829 25 . . . cord-010119-t1x9gknd 3830 1 Nearly nearly RB cord-010119-t1x9gknd 3830 2 all all PDT cord-010119-t1x9gknd 3830 3 the the DT cord-010119-t1x9gknd 3830 4 aPRP aPRP NNP cord-010119-t1x9gknd 3830 5 manufacturing manufacturing NN cord-010119-t1x9gknd 3830 6 was be VBD cord-010119-t1x9gknd 3830 7 done do VBN cord-010119-t1x9gknd 3830 8 with with IN cord-010119-t1x9gknd 3830 9 no no DT cord-010119-t1x9gknd 3830 10 quality quality NN cord-010119-t1x9gknd 3830 11 control control NN cord-010119-t1x9gknd 3830 12 ( ( -LRB- cord-010119-t1x9gknd 3830 13 QC QC NNP cord-010119-t1x9gknd 3830 14 ) ) -RRB- cord-010119-t1x9gknd 3830 15 measures measure NNS cord-010119-t1x9gknd 3830 16 ( ( -LRB- cord-010119-t1x9gknd 3830 17 97 97 CD cord-010119-t1x9gknd 3830 18 % % NN cord-010119-t1x9gknd 3830 19 ) ) -RRB- cord-010119-t1x9gknd 3830 20 ; ; : cord-010119-t1x9gknd 3830 21 however however RB cord-010119-t1x9gknd 3830 22 , , , cord-010119-t1x9gknd 3830 23 3 3 CD cord-010119-t1x9gknd 3830 24 respondents respondent NNS cord-010119-t1x9gknd 3830 25 assessed assess VBD cord-010119-t1x9gknd 3830 26 the the DT cord-010119-t1x9gknd 3830 27 final final JJ cord-010119-t1x9gknd 3830 28 product product NN cord-010119-t1x9gknd 3830 29 prior prior RB cord-010119-t1x9gknd 3830 30 to to TO cord-010119-t1x9gknd 3830 31 release release NN cord-010119-t1x9gknd 3830 32 . . . cord-010119-t1x9gknd 3831 1 These these DT cord-010119-t1x9gknd 3831 2 QC QC NNP cord-010119-t1x9gknd 3831 3 measures measure NNS cord-010119-t1x9gknd 3831 4 included include VBD cord-010119-t1x9gknd 3831 5 a a DT cord-010119-t1x9gknd 3831 6 platelet platelet NN cord-010119-t1x9gknd 3831 7 count count NN cord-010119-t1x9gknd 3831 8 to to TO cord-010119-t1x9gknd 3831 9 measure measure VB cord-010119-t1x9gknd 3831 10 the the DT cord-010119-t1x9gknd 3831 11 enrichment enrichment NN cord-010119-t1x9gknd 3831 12 of of IN cord-010119-t1x9gknd 3831 13 the the DT cord-010119-t1x9gknd 3831 14 platelet platelet NN cord-010119-t1x9gknd 3831 15 fraction fraction NN cord-010119-t1x9gknd 3831 16 , , , cord-010119-t1x9gknd 3831 17 culturing culture VBG cord-010119-t1x9gknd 3831 18 the the DT cord-010119-t1x9gknd 3831 19 product product NN cord-010119-t1x9gknd 3831 20 and and CC cord-010119-t1x9gknd 3831 21 infectious infectious JJ cord-010119-t1x9gknd 3831 22 serology serology NN cord-010119-t1x9gknd 3831 23 testing testing NN cord-010119-t1x9gknd 3831 24 . . . cord-010119-t1x9gknd 3832 1 In in IN cord-010119-t1x9gknd 3832 2 some some DT cord-010119-t1x9gknd 3832 3 cases case NNS cord-010119-t1x9gknd 3832 4 , , , cord-010119-t1x9gknd 3832 5 if if IN cord-010119-t1x9gknd 3832 6 the the DT cord-010119-t1x9gknd 3832 7 aPRP aPRP NNP cord-010119-t1x9gknd 3832 8 failed fail VBD cord-010119-t1x9gknd 3832 9 QC QC NNP cord-010119-t1x9gknd 3832 10 it -PRON- PRP cord-010119-t1x9gknd 3832 11 could could MD cord-010119-t1x9gknd 3832 12 still still RB cord-010119-t1x9gknd 3832 13 be be VB cord-010119-t1x9gknd 3832 14 used use VBN cord-010119-t1x9gknd 3832 15 , , , cord-010119-t1x9gknd 3832 16 pending pende VBG cord-010119-t1x9gknd 3832 17 an an DT cord-010119-t1x9gknd 3832 18 MD MD NNP cord-010119-t1x9gknd 3832 19 's 's POS cord-010119-t1x9gknd 3832 20 approval approval NN cord-010119-t1x9gknd 3832 21 . . . cord-010119-t1x9gknd 3833 1 In in IN cord-010119-t1x9gknd 3833 2 the the DT cord-010119-t1x9gknd 3833 3 3 3 CD cord-010119-t1x9gknd 3833 4 hospitals hospital NNS cord-010119-t1x9gknd 3833 5 conducting conduct VBG cord-010119-t1x9gknd 3833 6 QC QC NNP cord-010119-t1x9gknd 3833 7 on on IN cord-010119-t1x9gknd 3833 8 the the DT cord-010119-t1x9gknd 3833 9 final final JJ cord-010119-t1x9gknd 3833 10 aPRP aPRP NNP cord-010119-t1x9gknd 3833 11 , , , cord-010119-t1x9gknd 3833 12 the the DT cord-010119-t1x9gknd 3833 13 testing testing NN cord-010119-t1x9gknd 3833 14 was be VBD cord-010119-t1x9gknd 3833 15 done do VBN cord-010119-t1x9gknd 3833 16 by by IN cord-010119-t1x9gknd 3833 17 the the DT cord-010119-t1x9gknd 3833 18 blood blood NN cord-010119-t1x9gknd 3833 19 bank bank NN cord-010119-t1x9gknd 3833 20 . . . cord-010119-t1x9gknd 3834 1 A a DT cord-010119-t1x9gknd 3834 2 subset subset NN cord-010119-t1x9gknd 3834 3 of of IN cord-010119-t1x9gknd 3834 4 respondents respondent NNS cord-010119-t1x9gknd 3834 5 from from IN cord-010119-t1x9gknd 3834 6 African african JJ cord-010119-t1x9gknd 3834 7 nations nation NNS cord-010119-t1x9gknd 3834 8 also also RB cord-010119-t1x9gknd 3834 9 used use VBD cord-010119-t1x9gknd 3834 10 allogeneic allogeneic NN cord-010119-t1x9gknd 3834 11 PRP PRP NNP cord-010119-t1x9gknd 3834 12 ( ( -LRB- cord-010119-t1x9gknd 3834 13 allPRP allPRP NNP cord-010119-t1x9gknd 3834 14 ) ) -RRB- cord-010119-t1x9gknd 3834 15 . . . cord-010119-t1x9gknd 3835 1 In in IN cord-010119-t1x9gknd 3835 2 contrast contrast NN cord-010119-t1x9gknd 3835 3 to to IN cord-010119-t1x9gknd 3835 4 the the DT cord-010119-t1x9gknd 3835 5 patterns pattern NNS cord-010119-t1x9gknd 3835 6 of of IN cord-010119-t1x9gknd 3835 7 use use NN cord-010119-t1x9gknd 3835 8 with with IN cord-010119-t1x9gknd 3835 9 aPRP aPRP NNP cord-010119-t1x9gknd 3835 10 , , , cord-010119-t1x9gknd 3835 11 allPRP allPRP NNP cord-010119-t1x9gknd 3835 12 was be VBD cord-010119-t1x9gknd 3835 13 used use VBN cord-010119-t1x9gknd 3835 14 primarily primarily RB cord-010119-t1x9gknd 3835 15 for for IN cord-010119-t1x9gknd 3835 16 inpatients inpatient NNS cord-010119-t1x9gknd 3835 17 for for IN cord-010119-t1x9gknd 3835 18 indications indication NNS cord-010119-t1x9gknd 3835 19 including include VBG cord-010119-t1x9gknd 3835 20 orthopedics orthopedic NNS cord-010119-t1x9gknd 3835 21 , , , cord-010119-t1x9gknd 3835 22 wound wound NN cord-010119-t1x9gknd 3835 23 / / SYM cord-010119-t1x9gknd 3835 24 incision incision NN cord-010119-t1x9gknd 3835 25 repair repair NN cord-010119-t1x9gknd 3835 26 and and CC cord-010119-t1x9gknd 3835 27 ' ' `` cord-010119-t1x9gknd 3835 28 other other JJ cord-010119-t1x9gknd 3835 29 ' ' '' cord-010119-t1x9gknd 3835 30 . . . cord-010119-t1x9gknd 3836 1 The the DT cord-010119-t1x9gknd 3836 2 allPRP allPRP NNP cord-010119-t1x9gknd 3836 3 was be VBD cord-010119-t1x9gknd 3836 4 manufactured manufacture VBN cord-010119-t1x9gknd 3836 5 in in IN cord-010119-t1x9gknd 3836 6 the the DT cord-010119-t1x9gknd 3836 7 blood blood NN cord-010119-t1x9gknd 3836 8 bank bank NN cord-010119-t1x9gknd 3836 9 or or CC cord-010119-t1x9gknd 3836 10 the the DT cord-010119-t1x9gknd 3836 11 donor donor NN cord-010119-t1x9gknd 3836 12 center center NN cord-010119-t1x9gknd 3836 13 with with IN cord-010119-t1x9gknd 3836 14 no no DT cord-010119-t1x9gknd 3836 15 QC QC NNP cord-010119-t1x9gknd 3836 16 other other JJ cord-010119-t1x9gknd 3836 17 than than IN cord-010119-t1x9gknd 3836 18 a a DT cord-010119-t1x9gknd 3836 19 regular regular JJ cord-010119-t1x9gknd 3836 20 check check NN cord-010119-t1x9gknd 3836 21 of of IN cord-010119-t1x9gknd 3836 22 the the DT cord-010119-t1x9gknd 3836 23 centrifuge centrifuge NN cord-010119-t1x9gknd 3836 24 used use VBN cord-010119-t1x9gknd 3836 25 to to TO cord-010119-t1x9gknd 3836 26 isolate isolate VB cord-010119-t1x9gknd 3836 27 the the DT cord-010119-t1x9gknd 3836 28 PRP PRP NNP cord-010119-t1x9gknd 3836 29 fraction fraction NN cord-010119-t1x9gknd 3836 30 . . . cord-010119-t1x9gknd 3837 1 Conclusion conclusion NN cord-010119-t1x9gknd 3837 2 : : : cord-010119-t1x9gknd 3837 3 PRP PRP NNP cord-010119-t1x9gknd 3837 4 is be VBZ cord-010119-t1x9gknd 3837 5 used use VBN cord-010119-t1x9gknd 3837 6 in in IN cord-010119-t1x9gknd 3837 7 hospitals hospital NNS cord-010119-t1x9gknd 3837 8 throughout throughout IN cord-010119-t1x9gknd 3837 9 the the DT cord-010119-t1x9gknd 3837 10 world world NN cord-010119-t1x9gknd 3837 11 for for IN cord-010119-t1x9gknd 3837 12 a a DT cord-010119-t1x9gknd 3837 13 wide wide JJ cord-010119-t1x9gknd 3837 14 variety variety NN cord-010119-t1x9gknd 3837 15 of of IN cord-010119-t1x9gknd 3837 16 indications indication NNS cord-010119-t1x9gknd 3837 17 . . . cord-010119-t1x9gknd 3838 1 The the DT cord-010119-t1x9gknd 3838 2 blood blood NN cord-010119-t1x9gknd 3838 3 bank bank NN cord-010119-t1x9gknd 3838 4 is be VBZ cord-010119-t1x9gknd 3838 5 involved involve VBN cord-010119-t1x9gknd 3838 6 in in IN cord-010119-t1x9gknd 3838 7 its -PRON- PRP$ cord-010119-t1x9gknd 3838 8 manufacture manufacture NN cord-010119-t1x9gknd 3838 9 in in IN cord-010119-t1x9gknd 3838 10 some some DT cord-010119-t1x9gknd 3838 11 countries country NNS cord-010119-t1x9gknd 3838 12 , , , cord-010119-t1x9gknd 3838 13 but but CC cord-010119-t1x9gknd 3838 14 in in IN cord-010119-t1x9gknd 3838 15 the the DT cord-010119-t1x9gknd 3838 16 US US NNP cord-010119-t1x9gknd 3838 17 aPRP aPRP NNP cord-010119-t1x9gknd 3838 18 is be VBZ cord-010119-t1x9gknd 3838 19 made make VBN cord-010119-t1x9gknd 3838 20 outside outside RB cord-010119-t1x9gknd 3838 21 of of IN cord-010119-t1x9gknd 3838 22 the the DT cord-010119-t1x9gknd 3838 23 blood blood NN cord-010119-t1x9gknd 3838 24 bank bank NN cord-010119-t1x9gknd 3838 25 . . . cord-010119-t1x9gknd 3839 1 Quality quality NN cord-010119-t1x9gknd 3839 2 control control NN cord-010119-t1x9gknd 3839 3 of of IN cord-010119-t1x9gknd 3839 4 aPRP aPRP NNS cord-010119-t1x9gknd 3839 5 production production NN cord-010119-t1x9gknd 3839 6 and and CC cord-010119-t1x9gknd 3840 1 the the DT cord-010119-t1x9gknd 3840 2 final final JJ cord-010119-t1x9gknd 3840 3 product product NN cord-010119-t1x9gknd 3840 4 is be VBZ cord-010119-t1x9gknd 3840 5 not not RB cord-010119-t1x9gknd 3840 6 done do VBN cord-010119-t1x9gknd 3840 7 in in IN cord-010119-t1x9gknd 3840 8 most most JJS cord-010119-t1x9gknd 3840 9 hospitals hospital NNS cord-010119-t1x9gknd 3840 10 . . . cord-010119-t1x9gknd 3841 1 To to TO cord-010119-t1x9gknd 3841 2 improve improve VB cord-010119-t1x9gknd 3841 3 the the DT cord-010119-t1x9gknd 3841 4 consistency consistency NN cord-010119-t1x9gknd 3841 5 and and CC cord-010119-t1x9gknd 3841 6 efficacy efficacy NN cord-010119-t1x9gknd 3841 7 of of IN cord-010119-t1x9gknd 3841 8 PRP PRP NNP cord-010119-t1x9gknd 3841 9 , , , cord-010119-t1x9gknd 3841 10 more more RBR cord-010119-t1x9gknd 3841 11 stringent stringent JJ cord-010119-t1x9gknd 3841 12 QC QC NNP cord-010119-t1x9gknd 3841 13 measures measure NNS cord-010119-t1x9gknd 3841 14 need need VBP cord-010119-t1x9gknd 3841 15 to to TO cord-010119-t1x9gknd 3841 16 be be VB cord-010119-t1x9gknd 3841 17 in in IN cord-010119-t1x9gknd 3841 18 place place NN cord-010119-t1x9gknd 3841 19 . . . cord-010119-t1x9gknd 3842 1 Background Background NNP cord-010119-t1x9gknd 3842 2 / / SYM cord-010119-t1x9gknd 3842 3 Case Case NNP cord-010119-t1x9gknd 3842 4 Studies Studies NNPS cord-010119-t1x9gknd 3842 5 : : : cord-010119-t1x9gknd 3843 1 The the DT cord-010119-t1x9gknd 3843 2 morphology morphology NN cord-010119-t1x9gknd 3843 3 of of IN cord-010119-t1x9gknd 3843 4 donated donate VBN cord-010119-t1x9gknd 3843 5 red red JJ cord-010119-t1x9gknd 3843 6 blood blood NN cord-010119-t1x9gknd 3843 7 cells cell NNS cord-010119-t1x9gknd 3843 8 ( ( -LRB- cord-010119-t1x9gknd 3843 9 RBC RBC NNP cord-010119-t1x9gknd 3843 10 ) ) -RRB- cord-010119-t1x9gknd 3843 11 change change NN cord-010119-t1x9gknd 3843 12 with with IN cord-010119-t1x9gknd 3843 13 storage storage NN cord-010119-t1x9gknd 3843 14 , , , cord-010119-t1x9gknd 3843 15 along along IN cord-010119-t1x9gknd 3843 16 with with IN cord-010119-t1x9gknd 3843 17 a a DT cord-010119-t1x9gknd 3843 18 loss loss NN cord-010119-t1x9gknd 3843 19 of of IN cord-010119-t1x9gknd 3843 20 deformability deformability NN cord-010119-t1x9gknd 3843 21 , , , cord-010119-t1x9gknd 3843 22 increased increase VBN cord-010119-t1x9gknd 3843 23 surface surface NN cord-010119-t1x9gknd 3843 24 exposure exposure NN cord-010119-t1x9gknd 3843 25 of of IN cord-010119-t1x9gknd 3843 26 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 3843 27 ( ( -LRB- cord-010119-t1x9gknd 3843 28 PS PS NNP cord-010119-t1x9gknd 3843 29 ) ) -RRB- cord-010119-t1x9gknd 3843 30 , , , cord-010119-t1x9gknd 3843 31 and and CC cord-010119-t1x9gknd 3843 32 decreased decrease VBD cord-010119-t1x9gknd 3843 33 intracellular intracellular JJ cord-010119-t1x9gknd 3843 34 ATP ATP NNP cord-010119-t1x9gknd 3843 35 . . . cord-010119-t1x9gknd 3844 1 These these DT cord-010119-t1x9gknd 3844 2 changes change NNS cord-010119-t1x9gknd 3844 3 have have VBP cord-010119-t1x9gknd 3844 4 been be VBN cord-010119-t1x9gknd 3844 5 associated associate VBN cord-010119-t1x9gknd 3844 6 with with IN cord-010119-t1x9gknd 3844 7 increased increase VBN cord-010119-t1x9gknd 3844 8 RBC RBC NNP cord-010119-t1x9gknd 3844 9 clearance clearance NN cord-010119-t1x9gknd 3844 10 within within IN cord-010119-t1x9gknd 3844 11 hours hour NNS cord-010119-t1x9gknd 3844 12 of of IN cord-010119-t1x9gknd 3844 13 transfusion transfusion NN cord-010119-t1x9gknd 3844 14 . . . cord-010119-t1x9gknd 3845 1 Analysis analysis NN cord-010119-t1x9gknd 3845 2 of of IN cord-010119-t1x9gknd 3845 3 morphological morphological JJ cord-010119-t1x9gknd 3845 4 alterations alteration NNS cord-010119-t1x9gknd 3845 5 of of IN cord-010119-t1x9gknd 3845 6 stored store VBN cord-010119-t1x9gknd 3845 7 RBC RBC NNP cord-010119-t1x9gknd 3845 8 with with IN cord-010119-t1x9gknd 3845 9 imaging imaging NN cord-010119-t1x9gknd 3845 10 flow flow NN cord-010119-t1x9gknd 3845 11 cytometry cytometry NN cord-010119-t1x9gknd 3845 12 ( ( -LRB- cord-010119-t1x9gknd 3845 13 IFC IFC NNP cord-010119-t1x9gknd 3845 14 ) ) -RRB- cord-010119-t1x9gknd 3845 15 has have VBZ cord-010119-t1x9gknd 3845 16 identified identify VBN cord-010119-t1x9gknd 3845 17 a a DT cord-010119-t1x9gknd 3845 18 subpopulation subpopulation NN cord-010119-t1x9gknd 3845 19 of of IN cord-010119-t1x9gknd 3845 20 small small JJ cord-010119-t1x9gknd 3845 21 RBC RBC NNP cord-010119-t1x9gknd 3845 22 that that WDT cord-010119-t1x9gknd 3845 23 accumulates accumulate VBZ cord-010119-t1x9gknd 3845 24 upon upon IN cord-010119-t1x9gknd 3845 25 storage storage NN cord-010119-t1x9gknd 3845 26 . . . cord-010119-t1x9gknd 3846 1 This this DT cord-010119-t1x9gknd 3846 2 RBC RBC NNP cord-010119-t1x9gknd 3846 3 subpopulation subpopulation NN cord-010119-t1x9gknd 3846 4 has have VBZ cord-010119-t1x9gknd 3846 5 a a DT cord-010119-t1x9gknd 3846 6 reduced reduce VBN cord-010119-t1x9gknd 3846 7 projected project VBN cord-010119-t1x9gknd 3846 8 surface surface NN cord-010119-t1x9gknd 3846 9 area area NN cord-010119-t1x9gknd 3846 10 and and CC cord-010119-t1x9gknd 3846 11 undergoes undergo VBZ cord-010119-t1x9gknd 3846 12 a a DT cord-010119-t1x9gknd 3846 13 spherocytic spherocytic JJ cord-010119-t1x9gknd 3846 14 shift shift NN cord-010119-t1x9gknd 3846 15 which which WDT cord-010119-t1x9gknd 3846 16 is be VBZ cord-010119-t1x9gknd 3846 17 expected expect VBN cord-010119-t1x9gknd 3846 18 to to TO cord-010119-t1x9gknd 3846 19 induce induce VB cord-010119-t1x9gknd 3846 20 their -PRON- PRP$ cord-010119-t1x9gknd 3846 21 retention retention NN cord-010119-t1x9gknd 3846 22 in in IN cord-010119-t1x9gknd 3846 23 the the DT cord-010119-t1x9gknd 3846 24 spleen spleen NN cord-010119-t1x9gknd 3846 25 ( ( -LRB- cord-010119-t1x9gknd 3846 26 Roussel Roussel NNP cord-010119-t1x9gknd 3846 27 , , , cord-010119-t1x9gknd 3846 28 Dussiot Dussiot NNP cord-010119-t1x9gknd 3846 29 et et FW cord-010119-t1x9gknd 3846 30 al al NNP cord-010119-t1x9gknd 3846 31 , , , cord-010119-t1x9gknd 3846 32 2017 2017 CD cord-010119-t1x9gknd 3846 33 ) ) -RRB- cord-010119-t1x9gknd 3846 34 . . . cord-010119-t1x9gknd 3847 1 Some some DT cord-010119-t1x9gknd 3847 2 of of IN cord-010119-t1x9gknd 3847 3 the the DT cord-010119-t1x9gknd 3847 4 storage storage NN cord-010119-t1x9gknd 3847 5 alterations alteration NNS cord-010119-t1x9gknd 3847 6 are be VBP cord-010119-t1x9gknd 3847 7 reversible reversible JJ cord-010119-t1x9gknd 3847 8 when when WRB cord-010119-t1x9gknd 3847 9 the the DT cord-010119-t1x9gknd 3847 10 RBC RBC NNP cord-010119-t1x9gknd 3847 11 metabolism metabolism NN cord-010119-t1x9gknd 3847 12 is be VBZ cord-010119-t1x9gknd 3847 13 reestablished reestablish VBN cord-010119-t1x9gknd 3847 14 . . . cord-010119-t1x9gknd 3848 1 As as IN cord-010119-t1x9gknd 3848 2 such such JJ cord-010119-t1x9gknd 3848 3 , , , cord-010119-t1x9gknd 3848 4 treatment treatment NN cord-010119-t1x9gknd 3848 5 with with IN cord-010119-t1x9gknd 3848 6 a a DT cord-010119-t1x9gknd 3848 7 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3848 8 solution solution NN cord-010119-t1x9gknd 3848 9 ( ( -LRB- cord-010119-t1x9gknd 3848 10 Citra Citra NNP cord-010119-t1x9gknd 3848 11 Labs Labs NNP cord-010119-t1x9gknd 3848 12 ) ) -RRB- cord-010119-t1x9gknd 3848 13 before before IN cord-010119-t1x9gknd 3848 14 transfusion transfusion NN cord-010119-t1x9gknd 3848 15 is be VBZ cord-010119-t1x9gknd 3848 16 expected expect VBN cord-010119-t1x9gknd 3848 17 to to TO cord-010119-t1x9gknd 3848 18 restore restore VB cord-010119-t1x9gknd 3848 19 some some DT cord-010119-t1x9gknd 3848 20 of of IN cord-010119-t1x9gknd 3848 21 the the DT cord-010119-t1x9gknd 3848 22 RBC RBC NNP cord-010119-t1x9gknd 3848 23 properties property NNS cord-010119-t1x9gknd 3848 24 and and CC cord-010119-t1x9gknd 3848 25 thus thus RB cord-010119-t1x9gknd 3848 26 potentially potentially RB cord-010119-t1x9gknd 3848 27 increase increase VB cord-010119-t1x9gknd 3848 28 their -PRON- PRP$ cord-010119-t1x9gknd 3848 29 capacity capacity NN cord-010119-t1x9gknd 3848 30 to to TO cord-010119-t1x9gknd 3848 31 stay stay VB cord-010119-t1x9gknd 3848 32 in in IN cord-010119-t1x9gknd 3848 33 circulation circulation NN cord-010119-t1x9gknd 3848 34 and and CC cord-010119-t1x9gknd 3848 35 operate operate VBP cord-010119-t1x9gknd 3848 36 effective effective JJ cord-010119-t1x9gknd 3848 37 tissue tissue NN cord-010119-t1x9gknd 3848 38 oxygenation oxygenation NN cord-010119-t1x9gknd 3848 39 following follow VBG cord-010119-t1x9gknd 3848 40 transfusion transfusion NN cord-010119-t1x9gknd 3848 41 . . . cord-010119-t1x9gknd 3849 1 Study Study NNP cord-010119-t1x9gknd 3849 2 Design Design NNP cord-010119-t1x9gknd 3849 3 / / SYM cord-010119-t1x9gknd 3849 4 Methods method NNS cord-010119-t1x9gknd 3849 5 : : : cord-010119-t1x9gknd 3850 1 A a DT cord-010119-t1x9gknd 3850 2 multi multi JJ cord-010119-t1x9gknd 3850 3 - - JJ cord-010119-t1x9gknd 3850 4 parametric parametric JJ cord-010119-t1x9gknd 3850 5 analysis analysis NN cord-010119-t1x9gknd 3850 6 of of IN cord-010119-t1x9gknd 3850 7 RBC RBC NNP cord-010119-t1x9gknd 3850 8 alterations alteration NNS cord-010119-t1x9gknd 3850 9 was be VBD cord-010119-t1x9gknd 3850 10 performed perform VBN cord-010119-t1x9gknd 3850 11 to to TO cord-010119-t1x9gknd 3850 12 evaluate evaluate VB cord-010119-t1x9gknd 3850 13 the the DT cord-010119-t1x9gknd 3850 14 effect effect NN cord-010119-t1x9gknd 3850 15 of of IN cord-010119-t1x9gknd 3850 16 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3850 17 on on IN cord-010119-t1x9gknd 3850 18 RBCs rbc NNS cord-010119-t1x9gknd 3850 19 stored store VBN cord-010119-t1x9gknd 3850 20 in in IN cord-010119-t1x9gknd 3850 21 SAGM SAGM NNP cord-010119-t1x9gknd 3850 22 ( ( -LRB- cord-010119-t1x9gknd 3850 23 n56 n56 NN cord-010119-t1x9gknd 3850 24 ) ) -RRB- cord-010119-t1x9gknd 3850 25 under under IN cord-010119-t1x9gknd 3850 26 blood blood NN cord-010119-t1x9gknd 3850 27 bank bank NN cord-010119-t1x9gknd 3850 28 conditions condition NNS cord-010119-t1x9gknd 3850 29 at at IN cord-010119-t1x9gknd 3850 30 Day day NN cord-010119-t1x9gknd 3850 31 3 3 CD cord-010119-t1x9gknd 3850 32 ( ( -LRB- cord-010119-t1x9gknd 3850 33 D3 D3 NNP cord-010119-t1x9gknd 3850 34 ) ) -RRB- cord-010119-t1x9gknd 3850 35 , , , cord-010119-t1x9gknd 3850 36 at at IN cord-010119-t1x9gknd 3850 37 Day day NN cord-010119-t1x9gknd 3850 38 42 42 CD cord-010119-t1x9gknd 3850 39 ( ( -LRB- cord-010119-t1x9gknd 3850 40 D42 D42 NNP cord-010119-t1x9gknd 3850 41 ) ) -RRB- cord-010119-t1x9gknd 3850 42 , , , cord-010119-t1x9gknd 3850 43 after after IN cord-010119-t1x9gknd 3850 44 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3850 45 ( ( -LRB- cord-010119-t1x9gknd 3850 46 R r NN cord-010119-t1x9gknd 3850 47 ) ) -RRB- cord-010119-t1x9gknd 3850 48 , , , cord-010119-t1x9gknd 3850 49 and and CC cord-010119-t1x9gknd 3850 50 after after IN cord-010119-t1x9gknd 3850 51 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3850 52 and and CC cord-010119-t1x9gknd 3850 53 washing washing NN cord-010119-t1x9gknd 3850 54 ( ( -LRB- cord-010119-t1x9gknd 3850 55 RW RW NNP cord-010119-t1x9gknd 3850 56 ) ) -RRB- cord-010119-t1x9gknd 3850 57 . . . cord-010119-t1x9gknd 3851 1 Morphological morphological JJ cord-010119-t1x9gknd 3851 2 alterations alteration NNS cord-010119-t1x9gknd 3851 3 of of IN cord-010119-t1x9gknd 3851 4 stored store VBN cord-010119-t1x9gknd 3851 5 RBCs rbc NNS cord-010119-t1x9gknd 3851 6 were be VBD cord-010119-t1x9gknd 3851 7 evaluated evaluate VBN cord-010119-t1x9gknd 3851 8 with with IN cord-010119-t1x9gknd 3851 9 IFC IFC NNP cord-010119-t1x9gknd 3851 10 ( ( -LRB- cord-010119-t1x9gknd 3851 11 Imagestream Imagestream NNP cord-010119-t1x9gknd 3851 12 X X NNP cord-010119-t1x9gknd 3851 13 Mark Mark NNP cord-010119-t1x9gknd 3851 14 II II NNP cord-010119-t1x9gknd 3851 15 , , , cord-010119-t1x9gknd 3851 16 AMNIS amnis NN cord-010119-t1x9gknd 3851 17 V v NN cord-010119-t1x9gknd 3851 18 R r NN cord-010119-t1x9gknd 3851 19 ) ) -RRB- cord-010119-t1x9gknd 3851 20 . . . cord-010119-t1x9gknd 3852 1 Results/ Results/ . cord-010119-t1x9gknd 3853 1 Finding finding NN cord-010119-t1x9gknd 3853 2 : : : cord-010119-t1x9gknd 3854 1 Rejuvenation rejuvenation NN cord-010119-t1x9gknd 3854 2 increased increase VBD cord-010119-t1x9gknd 3854 3 the the DT cord-010119-t1x9gknd 3854 4 level level NN cord-010119-t1x9gknd 3854 5 of of IN cord-010119-t1x9gknd 3854 6 intracellular intracellular JJ cord-010119-t1x9gknd 3854 7 ATP ATP NNP cord-010119-t1x9gknd 3854 8 , , , cord-010119-t1x9gknd 3854 9 confirming confirm VBG cord-010119-t1x9gknd 3854 10 the the DT cord-010119-t1x9gknd 3854 11 metabolic metabolic JJ cord-010119-t1x9gknd 3854 12 effect effect NN cord-010119-t1x9gknd 3854 13 of of IN cord-010119-t1x9gknd 3854 14 this this DT cord-010119-t1x9gknd 3854 15 process process NN cord-010119-t1x9gknd 3854 16 . . . cord-010119-t1x9gknd 3855 1 Population population NN cord-010119-t1x9gknd 3855 2 distribution distribution NN cord-010119-t1x9gknd 3855 3 as as IN cord-010119-t1x9gknd 3855 4 per per IN cord-010119-t1x9gknd 3855 5 RBC RBC NNP cord-010119-t1x9gknd 3855 6 projected project VBN cord-010119-t1x9gknd 3855 7 surface surface NN cord-010119-t1x9gknd 3855 8 area area NN cord-010119-t1x9gknd 3855 9 measured measure VBN cord-010119-t1x9gknd 3855 10 by by IN cord-010119-t1x9gknd 3855 11 IFC IFC NNP cord-010119-t1x9gknd 3855 12 depicted depict VBD cord-010119-t1x9gknd 3855 13 a a DT cord-010119-t1x9gknd 3855 14 well well RB cord-010119-t1x9gknd 3855 15 - - HYPH cord-010119-t1x9gknd 3855 16 demarcated demarcate VBN cord-010119-t1x9gknd 3855 17 subpopulation subpopulation NN cord-010119-t1x9gknd 3855 18 of of IN cord-010119-t1x9gknd 3855 19 small small JJ cord-010119-t1x9gknd 3855 20 RBC RBC NNP cord-010119-t1x9gknd 3855 21 that that WDT cord-010119-t1x9gknd 3855 22 increased increase VBD cord-010119-t1x9gknd 3855 23 with with IN cord-010119-t1x9gknd 3855 24 storage storage NN cord-010119-t1x9gknd 3855 25 from from IN cord-010119-t1x9gknd 3855 26 2.1 2.1 CD cord-010119-t1x9gknd 3855 27 - - SYM cord-010119-t1x9gknd 3855 28 8.8 8.8 CD cord-010119-t1x9gknd 3855 29 % % NN cord-010119-t1x9gknd 3855 30 at at IN cord-010119-t1x9gknd 3855 31 D3 D3 NNP cord-010119-t1x9gknd 3855 32 to to IN cord-010119-t1x9gknd 3855 33 8.3 8.3 CD cord-010119-t1x9gknd 3855 34 - - HYPH cord-010119-t1x9gknd 3855 35 68.1 68.1 CD cord-010119-t1x9gknd 3855 36 % % NN cord-010119-t1x9gknd 3855 37 at at IN cord-010119-t1x9gknd 3855 38 D42 D42 NNP cord-010119-t1x9gknd 3855 39 . . . cord-010119-t1x9gknd 3856 1 Rejuvenation rejuvenation NN cord-010119-t1x9gknd 3856 2 markedly markedly RB cord-010119-t1x9gknd 3856 3 reduced reduce VBD cord-010119-t1x9gknd 3856 4 this this DT cord-010119-t1x9gknd 3856 5 storage storage NN cord-010119-t1x9gknd 3856 6 - - HYPH cord-010119-t1x9gknd 3856 7 induced induce VBN cord-010119-t1x9gknd 3856 8 spherocytic spherocytic JJ cord-010119-t1x9gknd 3856 9 shift shift NN cord-010119-t1x9gknd 3856 10 ( ( -LRB- cord-010119-t1x9gknd 3856 11 1.7 1.7 CD cord-010119-t1x9gknd 3856 12 - - SYM cord-010119-t1x9gknd 3856 13 29.3 29.3 CD cord-010119-t1x9gknd 3856 14 % % NN cord-010119-t1x9gknd 3856 15 ) ) -RRB- cord-010119-t1x9gknd 3856 16 and and CC cord-010119-t1x9gknd 3856 17 partially partially RB cord-010119-t1x9gknd 3856 18 restored restore VBN cord-010119-t1x9gknd 3856 19 RBC RBC NNP cord-010119-t1x9gknd 3856 20 morphology morphology NN cord-010119-t1x9gknd 3856 21 , , , cord-010119-t1x9gknd 3856 22 an an DT cord-010119-t1x9gknd 3856 23 effect effect NN cord-010119-t1x9gknd 3856 24 confirmed confirm VBN cord-010119-t1x9gknd 3856 25 by by IN cord-010119-t1x9gknd 3856 26 differential differential JJ cord-010119-t1x9gknd 3856 27 interference interference NN cord-010119-t1x9gknd 3856 28 contrast contrast NN cord-010119-t1x9gknd 3856 29 microscopy microscopy NN cord-010119-t1x9gknd 3856 30 . . . cord-010119-t1x9gknd 3857 1 The the DT cord-010119-t1x9gknd 3857 2 restoration restoration NN cord-010119-t1x9gknd 3857 3 effect effect NN cord-010119-t1x9gknd 3857 4 of of IN cord-010119-t1x9gknd 3857 5 the the DT cord-010119-t1x9gknd 3857 6 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3857 7 process process NN cord-010119-t1x9gknd 3857 8 did do VBD cord-010119-t1x9gknd 3857 9 not not RB cord-010119-t1x9gknd 3857 10 correct correct VB cord-010119-t1x9gknd 3857 11 the the DT cord-010119-t1x9gknd 3857 12 storage storage NN cord-010119-t1x9gknd 3857 13 - - HYPH cord-010119-t1x9gknd 3857 14 related relate VBN cord-010119-t1x9gknd 3857 15 loss loss NN cord-010119-t1x9gknd 3857 16 of of IN cord-010119-t1x9gknd 3857 17 RBC RBC NNP cord-010119-t1x9gknd 3857 18 elongation elongation NN cord-010119-t1x9gknd 3857 19 but but CC cord-010119-t1x9gknd 3857 20 was be VBD cord-010119-t1x9gknd 3857 21 associated associate VBN cord-010119-t1x9gknd 3857 22 with with IN cord-010119-t1x9gknd 3857 23 a a DT cord-010119-t1x9gknd 3857 24 decrease decrease NN cord-010119-t1x9gknd 3857 25 in in IN cord-010119-t1x9gknd 3857 26 PS PS NNP cord-010119-t1x9gknd 3857 27 exposure exposure NN cord-010119-t1x9gknd 3857 28 ( ( -LRB- cord-010119-t1x9gknd 3857 29 Table table NN cord-010119-t1x9gknd 3857 30 ) ) -RRB- cord-010119-t1x9gknd 3857 31 . . . cord-010119-t1x9gknd 3858 1 Conclusion conclusion NN cord-010119-t1x9gknd 3858 2 : : : cord-010119-t1x9gknd 3859 1 Our -PRON- PRP$ cord-010119-t1x9gknd 3859 2 multi multi JJ cord-010119-t1x9gknd 3859 3 - - JJ cord-010119-t1x9gknd 3859 4 parametric parametric JJ cord-010119-t1x9gknd 3859 5 analysis analysis NN cord-010119-t1x9gknd 3859 6 shows show VBZ cord-010119-t1x9gknd 3859 7 that that IN cord-010119-t1x9gknd 3859 8 some some DT cord-010119-t1x9gknd 3859 9 but but CC cord-010119-t1x9gknd 3859 10 not not RB cord-010119-t1x9gknd 3859 11 all all DT cord-010119-t1x9gknd 3859 12 storage storage NN cord-010119-t1x9gknd 3859 13 - - HYPH cord-010119-t1x9gknd 3859 14 related relate VBN cord-010119-t1x9gknd 3859 15 alterations alteration NNS cord-010119-t1x9gknd 3859 16 are be VBP cord-010119-t1x9gknd 3859 17 therefore therefore RB cord-010119-t1x9gknd 3859 18 corrected correct VBN cord-010119-t1x9gknd 3859 19 by by IN cord-010119-t1x9gknd 3859 20 metabolic metabolic JJ cord-010119-t1x9gknd 3859 21 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3859 22 . . . cord-010119-t1x9gknd 3860 1 The the DT cord-010119-t1x9gknd 3860 2 impact impact NN cord-010119-t1x9gknd 3860 3 of of IN cord-010119-t1x9gknd 3860 4 these these DT cord-010119-t1x9gknd 3860 5 effects effect NNS cord-010119-t1x9gknd 3860 6 while while IN cord-010119-t1x9gknd 3860 7 generally generally RB cord-010119-t1x9gknd 3860 8 positive positive JJ cord-010119-t1x9gknd 3860 9 at at IN cord-010119-t1x9gknd 3860 10 the the DT cord-010119-t1x9gknd 3860 11 cellular cellular JJ cord-010119-t1x9gknd 3860 12 scale scale NN cord-010119-t1x9gknd 3860 13 requires require VBZ cord-010119-t1x9gknd 3860 14 further further JJ cord-010119-t1x9gknd 3860 15 analysis analysis NN cord-010119-t1x9gknd 3860 16 by by IN cord-010119-t1x9gknd 3860 17 specific specific JJ cord-010119-t1x9gknd 3860 18 clinical clinical JJ cord-010119-t1x9gknd 3860 19 studies study NNS cord-010119-t1x9gknd 3860 20 assessing assess VBG cord-010119-t1x9gknd 3860 21 transfusion transfusion NN cord-010119-t1x9gknd 3860 22 yield yield NN cord-010119-t1x9gknd 3860 23 and and CC cord-010119-t1x9gknd 3860 24 tissue tissue NN cord-010119-t1x9gknd 3860 25 oxygenation oxygenation NN cord-010119-t1x9gknd 3860 26 . . . cord-010119-t1x9gknd 3861 1 Red Red NNP cord-010119-t1x9gknd 3861 2 Cell Cell NNP cord-010119-t1x9gknd 3861 3 Concentrate Concentrate NNP cord-010119-t1x9gknd 3861 4 Volume Volume NNP cord-010119-t1x9gknd 3861 5 and and CC cord-010119-t1x9gknd 3861 6 Manufacturing Manufacturing NNP cord-010119-t1x9gknd 3861 7 Method Method NNP cord-010119-t1x9gknd 3862 1 Impact Impact NNP cord-010119-t1x9gknd 3862 2 Post Post NNP cord-010119-t1x9gknd 3862 3 - - NNP cord-010119-t1x9gknd 3862 4 Thaw thaw JJ cord-010119-t1x9gknd 3862 5 Quality quality NN cord-010119-t1x9gknd 3862 6 in in IN cord-010119-t1x9gknd 3862 7 Cryopreserved Cryopreserved NNP cord-010119-t1x9gknd 3862 8 Products Products NNPS cord-010119-t1x9gknd 3862 9 Processed process VBN cord-010119-t1x9gknd 3862 10 Using use VBG cord-010119-t1x9gknd 3862 11 a a DT cord-010119-t1x9gknd 3862 12 Closed closed JJ cord-010119-t1x9gknd 3862 13 Cell cell NN cord-010119-t1x9gknd 3862 14 Processor Processor NNP cord-010119-t1x9gknd 3862 15 Anita Anita NNP cord-010119-t1x9gknd 3862 16 Howell Howell NNP cord-010119-t1x9gknd 3862 17 1 1 CD cord-010119-t1x9gknd 3862 18 , , , cord-010119-t1x9gknd 3862 19 Angela Angela NNP cord-010119-t1x9gknd 3862 20 Hill Hill NNP cord-010119-t1x9gknd 3862 21 1 1 CD cord-010119-t1x9gknd 3863 1 , , , cord-010119-t1x9gknd 3863 2 Tracey Tracey NNP cord-010119-t1x9gknd 3863 3 Turner Turner NNP cord-010119-t1x9gknd 3863 4 2 2 CD cord-010119-t1x9gknd 3863 5 , , , cord-010119-t1x9gknd 3863 6 April April NNP cord-010119-t1x9gknd 3863 7 Xu Xu NNP cord-010119-t1x9gknd 3863 8 2 2 CD cord-010119-t1x9gknd 3863 9 , , , cord-010119-t1x9gknd 3863 10 Brandie Brandie NNP cord-010119-t1x9gknd 3863 11 Dennis Dennis NNP cord-010119-t1x9gknd 3863 12 2 2 CD cord-010119-t1x9gknd 3863 13 and and CC cord-010119-t1x9gknd 3863 14 Jason Jason NNP cord-010119-t1x9gknd 3863 15 P. P. NNP cord-010119-t1x9gknd 3863 16 Acker Acker NNP cord-010119-t1x9gknd 3864 1 * * NFP cord-010119-t1x9gknd 3864 2 2,3 2,3 CD cord-010119-t1x9gknd 3864 3 . . . cord-010119-t1x9gknd 3864 4 1 1 CD cord-010119-t1x9gknd 3864 5 Canadian Canadian NNP cord-010119-t1x9gknd 3864 6 Blood Blood NNP cord-010119-t1x9gknd 3864 7 Services Services NNPS cord-010119-t1x9gknd 3864 8 , , , cord-010119-t1x9gknd 3864 9 Centre Centre NNP cord-010119-t1x9gknd 3864 10 for for IN cord-010119-t1x9gknd 3864 11 Innovation Innovation NNP cord-010119-t1x9gknd 3864 12 , , , cord-010119-t1x9gknd 3864 13 2 2 CD cord-010119-t1x9gknd 3864 14 Canadian Canadian NNP cord-010119-t1x9gknd 3864 15 Blood Blood NNP cord-010119-t1x9gknd 3864 16 Services Services NNPS cord-010119-t1x9gknd 3864 17 , , , cord-010119-t1x9gknd 3864 18 3 3 CD cord-010119-t1x9gknd 3864 19 University University NNP cord-010119-t1x9gknd 3864 20 of of IN cord-010119-t1x9gknd 3864 21 Alberta Alberta NNP cord-010119-t1x9gknd 3864 22 Background Background NNP cord-010119-t1x9gknd 3864 23 / / SYM cord-010119-t1x9gknd 3864 24 Case Case NNP cord-010119-t1x9gknd 3864 25 Studies Studies NNPS cord-010119-t1x9gknd 3864 26 : : : cord-010119-t1x9gknd 3865 1 The the DT cord-010119-t1x9gknd 3865 2 blood blood NN cord-010119-t1x9gknd 3865 3 service service NN cord-010119-t1x9gknd 3865 4 uses use VBZ cord-010119-t1x9gknd 3865 5 both both CC cord-010119-t1x9gknd 3865 6 top top JJ cord-010119-t1x9gknd 3865 7 / / SYM cord-010119-t1x9gknd 3865 8 top top NN cord-010119-t1x9gknd 3865 9 with with IN cord-010119-t1x9gknd 3865 10 whole whole JJ cord-010119-t1x9gknd 3865 11 blood blood NN cord-010119-t1x9gknd 3865 12 filtration filtration NN cord-010119-t1x9gknd 3865 13 ( ( -LRB- cord-010119-t1x9gknd 3865 14 WBF WBF NNP cord-010119-t1x9gknd 3865 15 ) ) -RRB- cord-010119-t1x9gknd 3865 16 and and CC cord-010119-t1x9gknd 3865 17 top top JJ cord-010119-t1x9gknd 3865 18 / / SYM cord-010119-t1x9gknd 3865 19 bottom bottom NN cord-010119-t1x9gknd 3865 20 with with IN cord-010119-t1x9gknd 3865 21 red red JJ cord-010119-t1x9gknd 3865 22 cell cell NN cord-010119-t1x9gknd 3865 23 filtration filtration NN cord-010119-t1x9gknd 3865 24 ( ( -LRB- cord-010119-t1x9gknd 3865 25 RCF RCF NNP cord-010119-t1x9gknd 3865 26 ) ) -RRB- cord-010119-t1x9gknd 3865 27 methods method NNS cord-010119-t1x9gknd 3865 28 to to TO cord-010119-t1x9gknd 3865 29 prepare prepare VB cord-010119-t1x9gknd 3865 30 CPD CPD NNP cord-010119-t1x9gknd 3865 31 / / SYM cord-010119-t1x9gknd 3865 32 SAGM SAGM NNP cord-010119-t1x9gknd 3865 33 LR LR NNP cord-010119-t1x9gknd 3865 34 red red JJ cord-010119-t1x9gknd 3865 35 cell cell NN cord-010119-t1x9gknd 3865 36 concentrates concentrate VBZ cord-010119-t1x9gknd 3865 37 ( ( -LRB- cord-010119-t1x9gknd 3865 38 RCCs rccs NN cord-010119-t1x9gknd 3865 39 ) ) -RRB- cord-010119-t1x9gknd 3865 40 . . . cord-010119-t1x9gknd 3866 1 Mean mean JJ cord-010119-t1x9gknd 3866 2 volume volume NN cord-010119-t1x9gknd 3866 3 ( ( -LRB- cord-010119-t1x9gknd 3866 4 mL ml NN cord-010119-t1x9gknd 3866 5 ) ) -RRB- cord-010119-t1x9gknd 3866 6 is be VBZ cord-010119-t1x9gknd 3866 7 higher high JJR cord-010119-t1x9gknd 3866 8 in in IN cord-010119-t1x9gknd 3866 9 WBF WBF NNP cord-010119-t1x9gknd 3866 10 units unit NNS cord-010119-t1x9gknd 3866 11 ( ( -LRB- cord-010119-t1x9gknd 3866 12 314 314 CD cord-010119-t1x9gknd 3866 13 6 6 CD cord-010119-t1x9gknd 3866 14 15 15 CD cord-010119-t1x9gknd 3866 15 ) ) -RRB- cord-010119-t1x9gknd 3866 16 than than IN cord-010119-t1x9gknd 3866 17 in in IN cord-010119-t1x9gknd 3866 18 RCF RCF NNP cord-010119-t1x9gknd 3866 19 units unit NNS cord-010119-t1x9gknd 3866 20 ( ( -LRB- cord-010119-t1x9gknd 3866 21 275 275 CD cord-010119-t1x9gknd 3866 22 6 6 CD cord-010119-t1x9gknd 3866 23 16 16 CD cord-010119-t1x9gknd 3866 24 ) ) -RRB- cord-010119-t1x9gknd 3866 25 , , , cord-010119-t1x9gknd 3866 26 with with IN cord-010119-t1x9gknd 3866 27 similar similar JJ cord-010119-t1x9gknd 3866 28 hematocrits hematocrit NNS cord-010119-t1x9gknd 3866 29 . . . cord-010119-t1x9gknd 3867 1 A a DT cord-010119-t1x9gknd 3867 2 closed closed JJ cord-010119-t1x9gknd 3867 3 system system NN cord-010119-t1x9gknd 3867 4 cell cell NN cord-010119-t1x9gknd 3867 5 processor processor NN cord-010119-t1x9gknd 3867 6 is be VBZ cord-010119-t1x9gknd 3867 7 currently currently RB cord-010119-t1x9gknd 3867 8 being be VBG cord-010119-t1x9gknd 3867 9 implemented implement VBN cord-010119-t1x9gknd 3867 10 for for IN cord-010119-t1x9gknd 3867 11 cryopreservation cryopreservation NN cord-010119-t1x9gknd 3867 12 of of IN cord-010119-t1x9gknd 3867 13 RCCs rcc NNS cord-010119-t1x9gknd 3867 14 . . . cord-010119-t1x9gknd 3868 1 Post post JJ cord-010119-t1x9gknd 3868 2 - - JJ cord-010119-t1x9gknd 3868 3 deglycerolization deglycerolization NNP cord-010119-t1x9gknd 3868 4 re re NN cord-010119-t1x9gknd 3868 5 - - NN cord-010119-t1x9gknd 3868 6 suspension suspension NN cord-010119-t1x9gknd 3868 7 in in IN cord-010119-t1x9gknd 3868 8 AS-3 AS-3 NNP cord-010119-t1x9gknd 3868 9 additive additive NN cord-010119-t1x9gknd 3868 10 solution solution NN cord-010119-t1x9gknd 3868 11 is be VBZ cord-010119-t1x9gknd 3868 12 performed perform VBN cord-010119-t1x9gknd 3868 13 on on IN cord-010119-t1x9gknd 3868 14 - - HYPH cord-010119-t1x9gknd 3868 15 instrument instrument NN cord-010119-t1x9gknd 3868 16 to to IN cord-010119-t1x9gknd 3868 17 a a DT cord-010119-t1x9gknd 3868 18 defined define VBN cord-010119-t1x9gknd 3868 19 total total JJ cord-010119-t1x9gknd 3868 20 end end NN cord-010119-t1x9gknd 3868 21 volume volume NN cord-010119-t1x9gknd 3868 22 , , , cord-010119-t1x9gknd 3868 23 as as IN cord-010119-t1x9gknd 3868 24 dictated dictate VBN cord-010119-t1x9gknd 3868 25 by by IN cord-010119-t1x9gknd 3868 26 the the DT cord-010119-t1x9gknd 3868 27 centrifuge centrifuge NN cord-010119-t1x9gknd 3868 28 bowl bowl NN cord-010119-t1x9gknd 3868 29 size size NN cord-010119-t1x9gknd 3868 30 . . . cord-010119-t1x9gknd 3869 1 The the DT cord-010119-t1x9gknd 3869 2 impact impact NN cord-010119-t1x9gknd 3869 3 of of IN cord-010119-t1x9gknd 3869 4 the the DT cord-010119-t1x9gknd 3869 5 resulting result VBG cord-010119-t1x9gknd 3869 6 variation variation NN cord-010119-t1x9gknd 3869 7 in in IN cord-010119-t1x9gknd 3869 8 hematocrit hematocrit NN cord-010119-t1x9gknd 3869 9 on on IN cord-010119-t1x9gknd 3869 10 post post NN cord-010119-t1x9gknd 3869 11 - - JJ cord-010119-t1x9gknd 3869 12 thaw thaw VB cord-010119-t1x9gknd 3869 13 in in IN cord-010119-t1x9gknd 3869 14 vitroRBC vitroRBC NNP cord-010119-t1x9gknd 3869 15 quality quality NN cord-010119-t1x9gknd 3869 16 was be VBD cord-010119-t1x9gknd 3869 17 evaluated evaluate VBN cord-010119-t1x9gknd 3869 18 to to TO cord-010119-t1x9gknd 3869 19 ensure ensure VB cord-010119-t1x9gknd 3869 20 that that IN cord-010119-t1x9gknd 3869 21 regulatory regulatory JJ cord-010119-t1x9gknd 3869 22 standards standard NNS cord-010119-t1x9gknd 3869 23 can can MD cord-010119-t1x9gknd 3869 24 still still RB cord-010119-t1x9gknd 3869 25 be be VB cord-010119-t1x9gknd 3869 26 met meet VBN cord-010119-t1x9gknd 3869 27 for for IN cord-010119-t1x9gknd 3869 28 RCCs rcc NNS cord-010119-t1x9gknd 3869 29 at at IN cord-010119-t1x9gknd 3869 30 the the DT cord-010119-t1x9gknd 3869 31 extreme extreme JJ cord-010119-t1x9gknd 3869 32 edge edge NN cord-010119-t1x9gknd 3869 33 of of IN cord-010119-t1x9gknd 3869 34 the the DT cord-010119-t1x9gknd 3869 35 input input NN cord-010119-t1x9gknd 3869 36 volume volume NN cord-010119-t1x9gknd 3869 37 range range NN cord-010119-t1x9gknd 3869 38 . . . cord-010119-t1x9gknd 3870 1 Study Study NNP cord-010119-t1x9gknd 3870 2 Design Design NNP cord-010119-t1x9gknd 3870 3 / / SYM cord-010119-t1x9gknd 3870 4 Methods method NNS cord-010119-t1x9gknd 3870 5 : : : cord-010119-t1x9gknd 3870 6 12 12 CD cord-010119-t1x9gknd 3870 7 small small JJ cord-010119-t1x9gknd 3870 8 RCF RCF NNP cord-010119-t1x9gknd 3870 9 ( ( -LRB- cord-010119-t1x9gknd 3870 10 252 252 CD cord-010119-t1x9gknd 3870 11 - - SYM cord-010119-t1x9gknd 3870 12 263 263 CD cord-010119-t1x9gknd 3870 13 mL ml NN cord-010119-t1x9gknd 3870 14 ) ) -RRB- cord-010119-t1x9gknd 3870 15 and and CC cord-010119-t1x9gknd 3871 1 12 12 CD cord-010119-t1x9gknd 3871 2 large large JJ cord-010119-t1x9gknd 3871 3 WBF WBF NNP cord-010119-t1x9gknd 3871 4 ( ( -LRB- cord-010119-t1x9gknd 3871 5 322 322 CD cord-010119-t1x9gknd 3871 6 - - SYM cord-010119-t1x9gknd 3871 7 353 353 CD cord-010119-t1x9gknd 3871 8 mL ml NN cord-010119-t1x9gknd 3871 9 ) ) -RRB- cord-010119-t1x9gknd 3871 10 RCCs rcc NNS cord-010119-t1x9gknd 3871 11 were be VBD cord-010119-t1x9gknd 3871 12 stored store VBN cord-010119-t1x9gknd 3871 13 for for IN cord-010119-t1x9gknd 3871 14 21 21 CD cord-010119-t1x9gknd 3871 15 d d NN cord-010119-t1x9gknd 3871 16 before before IN cord-010119-t1x9gknd 3871 17 being be VBG cord-010119-t1x9gknd 3871 18 glycerolized glycerolize VBN cord-010119-t1x9gknd 3871 19 and and CC cord-010119-t1x9gknd 3871 20 frozen freeze VBN cord-010119-t1x9gknd 3871 21 at at IN cord-010119-t1x9gknd 3871 22 -658C -658c NN cord-010119-t1x9gknd 3871 23 for for IN cord-010119-t1x9gknd 3871 24 ! ! . cord-010119-t1x9gknd 3872 1 72 72 CD cord-010119-t1x9gknd 3872 2 h. h. NN cord-010119-t1x9gknd 3872 3 Large large JJ cord-010119-t1x9gknd 3872 4 RCCs rccs NN cord-010119-t1x9gknd 3872 5 whose whose WP$ cord-010119-t1x9gknd 3872 6 red red JJ cord-010119-t1x9gknd 3872 7 cell cell NN cord-010119-t1x9gknd 3872 8 mass mass NN cord-010119-t1x9gknd 3872 9 exceeded exceed VBD cord-010119-t1x9gknd 3872 10 the the DT cord-010119-t1x9gknd 3872 11 capacity capacity NN cord-010119-t1x9gknd 3872 12 of of IN cord-010119-t1x9gknd 3872 13 the the DT cord-010119-t1x9gknd 3872 14 275 275 CD cord-010119-t1x9gknd 3872 15 mL ml NN cord-010119-t1x9gknd 3872 16 deglycerolization deglycerolization NN cord-010119-t1x9gknd 3872 17 centrifuge centrifuge NN cord-010119-t1x9gknd 3872 18 bowl bowl NN cord-010119-t1x9gknd 3872 19 were be VBD cord-010119-t1x9gknd 3872 20 volume volume NN cord-010119-t1x9gknd 3872 21 reduced reduce VBN cord-010119-t1x9gknd 3872 22 prior prior RB cord-010119-t1x9gknd 3872 23 to to IN cord-010119-t1x9gknd 3872 24 glycerolization glycerolization NN cord-010119-t1x9gknd 3872 25 . . . cord-010119-t1x9gknd 3873 1 RCCs rcc NNS cord-010119-t1x9gknd 3873 2 were be VBD cord-010119-t1x9gknd 3873 3 thawed thaw VBN cord-010119-t1x9gknd 3873 4 in in IN cord-010119-t1x9gknd 3873 5 a a DT cord-010119-t1x9gknd 3873 6 378C 378c CD cord-010119-t1x9gknd 3873 7 water water NN cord-010119-t1x9gknd 3873 8 bath bath NN cord-010119-t1x9gknd 3873 9 , , , cord-010119-t1x9gknd 3873 10 deglycerolized deglycerolize VBN cord-010119-t1x9gknd 3873 11 and and CC cord-010119-t1x9gknd 3873 12 re re NNS cord-010119-t1x9gknd 3873 13 - - VBN cord-010119-t1x9gknd 3873 14 suspended suspend VBN cord-010119-t1x9gknd 3873 15 in in IN cord-010119-t1x9gknd 3873 16 AS-3 AS-3 NNP cord-010119-t1x9gknd 3873 17 . . . cord-010119-t1x9gknd 3874 1 RCCs rcc NNS cord-010119-t1x9gknd 3874 2 were be VBD cord-010119-t1x9gknd 3874 3 stored store VBN cord-010119-t1x9gknd 3874 4 14 14 CD cord-010119-t1x9gknd 3874 5 d d NN cord-010119-t1x9gknd 3874 6 and and CC cord-010119-t1x9gknd 3874 7 then then RB cord-010119-t1x9gknd 3874 8 tested test VBN cord-010119-t1x9gknd 3874 9 for for IN cord-010119-t1x9gknd 3874 10 in in IN cord-010119-t1x9gknd 3874 11 vitroRBC vitroRBC NNP cord-010119-t1x9gknd 3874 12 quality quality NN cord-010119-t1x9gknd 3874 13 . . . cord-010119-t1x9gknd 3875 1 Results/ Results/ . cord-010119-t1x9gknd 3876 1 Finding finding NN cord-010119-t1x9gknd 3876 2 : : : cord-010119-t1x9gknd 3877 1 Small small JJ cord-010119-t1x9gknd 3877 2 RCF RCF NNP cord-010119-t1x9gknd 3877 3 RCCs rccs NN cord-010119-t1x9gknd 3877 4 had have VBD cord-010119-t1x9gknd 3877 5 lower low JJR cord-010119-t1x9gknd 3877 6 ( ( -LRB- cord-010119-t1x9gknd 3877 7 p<0.05 p<0.05 CD cord-010119-t1x9gknd 3877 8 ) ) -RRB- cord-010119-t1x9gknd 3877 9 hematocrit hematocrit NN cord-010119-t1x9gknd 3877 10 , , , cord-010119-t1x9gknd 3877 11 specific specific JJ cord-010119-t1x9gknd 3877 12 gravity gravity NN cord-010119-t1x9gknd 3877 13 , , , cord-010119-t1x9gknd 3877 14 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3877 15 per per IN cord-010119-t1x9gknd 3877 16 unit unit NN cord-010119-t1x9gknd 3877 17 , , , cord-010119-t1x9gknd 3877 18 supernatant supernatant JJ cord-010119-t1x9gknd 3877 19 K K NNP cord-010119-t1x9gknd 3877 20 1 1 CD cord-010119-t1x9gknd 3877 21 and and CC cord-010119-t1x9gknd 3877 22 Na Na NNP cord-010119-t1x9gknd 3877 23 1 1 CD cord-010119-t1x9gknd 3877 24 concentration concentration NN cord-010119-t1x9gknd 3877 25 , , , cord-010119-t1x9gknd 3877 26 deformability deformability NN cord-010119-t1x9gknd 3877 27 ( ( -LRB- cord-010119-t1x9gknd 3877 28 EI EI NNP cord-010119-t1x9gknd 3877 29 MAX MAX NNP cord-010119-t1x9gknd 3877 30 ) ) -RRB- cord-010119-t1x9gknd 3877 31 , , , cord-010119-t1x9gknd 3877 32 and and CC cord-010119-t1x9gknd 3877 33 higher high JJR cord-010119-t1x9gknd 3877 34 ( ( -LRB- cord-010119-t1x9gknd 3877 35 p<0.001 p<0.001 JJ cord-010119-t1x9gknd 3877 36 ) ) -RRB- cord-010119-t1x9gknd 3877 37 recovery recovery NN cord-010119-t1x9gknd 3877 38 than than IN cord-010119-t1x9gknd 3877 39 did do VBD cord-010119-t1x9gknd 3877 40 large large JJ cord-010119-t1x9gknd 3877 41 WBF WBF NNP cord-010119-t1x9gknd 3877 42 units unit NNS cord-010119-t1x9gknd 3877 43 . . . cord-010119-t1x9gknd 3878 1 No no DT cord-010119-t1x9gknd 3878 2 significant significant JJ cord-010119-t1x9gknd 3878 3 differences difference NNS cord-010119-t1x9gknd 3878 4 in in IN cord-010119-t1x9gknd 3878 5 hemolysis hemolysis NN cord-010119-t1x9gknd 3878 6 , , , cord-010119-t1x9gknd 3878 7 ATP ATP NNP cord-010119-t1x9gknd 3878 8 , , , cord-010119-t1x9gknd 3878 9 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3878 10 , , , cord-010119-t1x9gknd 3878 11 p50 p50 NN cord-010119-t1x9gknd 3878 12 , , , cord-010119-t1x9gknd 3878 13 RBC RBC NNP cord-010119-t1x9gknd 3878 14 indices index NNS cord-010119-t1x9gknd 3878 15 , , , cord-010119-t1x9gknd 3878 16 RBC RBC NNP cord-010119-t1x9gknd 3878 17 morphology morphology NN cord-010119-t1x9gknd 3878 18 , , , cord-010119-t1x9gknd 3878 19 or or CC cord-010119-t1x9gknd 3878 20 residual residual JJ cord-010119-t1x9gknd 3878 21 glycerol glycerol NN cord-010119-t1x9gknd 3878 22 were be VBD cord-010119-t1x9gknd 3878 23 seen see VBN cord-010119-t1x9gknd 3878 24 between between IN cord-010119-t1x9gknd 3878 25 groups group NNS cord-010119-t1x9gknd 3878 26 . . . cord-010119-t1x9gknd 3879 1 The the DT cord-010119-t1x9gknd 3879 2 majority majority NN cord-010119-t1x9gknd 3879 3 of of IN cord-010119-t1x9gknd 3879 4 units unit NNS cord-010119-t1x9gknd 3879 5 met meet VBD cord-010119-t1x9gknd 3879 6 acceptance acceptance NN cord-010119-t1x9gknd 3879 7 criteria criterion NNS cord-010119-t1x9gknd 3879 8 ( ( -LRB- cord-010119-t1x9gknd 3879 9 Table table NN cord-010119-t1x9gknd 3879 10 1 1 CD cord-010119-t1x9gknd 3879 11 ) ) -RRB- cord-010119-t1x9gknd 3879 12 , , , cord-010119-t1x9gknd 3879 13 however however RB cord-010119-t1x9gknd 3879 14 8 8 CD cord-010119-t1x9gknd 3879 15 of of IN cord-010119-t1x9gknd 3879 16 12 12 CD cord-010119-t1x9gknd 3879 17 large large JJ cord-010119-t1x9gknd 3879 18 WBF WBF NNP cord-010119-t1x9gknd 3879 19 units unit NNS cord-010119-t1x9gknd 3879 20 had have VBD cord-010119-t1x9gknd 3879 21 RBC RBC NNP cord-010119-t1x9gknd 3879 22 recoveries recovery NNS cord-010119-t1x9gknd 3879 23 < < XX cord-010119-t1x9gknd 3879 24 80 80 CD cord-010119-t1x9gknd 3879 25 % % NN cord-010119-t1x9gknd 3879 26 due due JJ cord-010119-t1x9gknd 3879 27 to to IN cord-010119-t1x9gknd 3879 28 pre pre JJ cord-010119-t1x9gknd 3879 29 - - JJ cord-010119-t1x9gknd 3879 30 glycerolization glycerolization JJ cord-010119-t1x9gknd 3879 31 volume volume NN cord-010119-t1x9gknd 3879 32 reduction reduction NN cord-010119-t1x9gknd 3879 33 , , , cord-010119-t1x9gknd 3879 34 and and CC cord-010119-t1x9gknd 3879 35 2 2 CD cord-010119-t1x9gknd 3879 36 of of IN cord-010119-t1x9gknd 3879 37 the the DT cord-010119-t1x9gknd 3879 38 small small JJ cord-010119-t1x9gknd 3879 39 RCF RCF NNP cord-010119-t1x9gknd 3879 40 units unit NNS cord-010119-t1x9gknd 3879 41 had have VBD cord-010119-t1x9gknd 3879 42 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3879 43 values value NNS cord-010119-t1x9gknd 3879 44 < < XX cord-010119-t1x9gknd 3879 45 35 35 CD cord-010119-t1x9gknd 3879 46 g g NN cord-010119-t1x9gknd 3879 47 per per IN cord-010119-t1x9gknd 3879 48 unit unit NN cord-010119-t1x9gknd 3879 49 . . . cord-010119-t1x9gknd 3880 1 When when WRB cord-010119-t1x9gknd 3880 2 the the DT cord-010119-t1x9gknd 3880 3 recovery recovery NN cord-010119-t1x9gknd 3880 4 and and CC cord-010119-t1x9gknd 3880 5 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3880 6 failure failure NN cord-010119-t1x9gknd 3880 7 rates rate NNS cord-010119-t1x9gknd 3880 8 are be VBP cord-010119-t1x9gknd 3880 9 analyzed analyze VBN cord-010119-t1x9gknd 3880 10 against against IN cord-010119-t1x9gknd 3880 11 the the DT cord-010119-t1x9gknd 3880 12 organization organization NN cord-010119-t1x9gknd 3880 13 's 's POS cord-010119-t1x9gknd 3880 14 RCC RCC NNP cord-010119-t1x9gknd 3880 15 production production NN cord-010119-t1x9gknd 3880 16 volume volume NN cord-010119-t1x9gknd 3880 17 distribution distribution NN cord-010119-t1x9gknd 3880 18 , , , cord-010119-t1x9gknd 3880 19 the the DT cord-010119-t1x9gknd 3880 20 mean mean JJ cord-010119-t1x9gknd 3880 21 recovery recovery NN cord-010119-t1x9gknd 3880 22 is be VBZ cord-010119-t1x9gknd 3880 23 projected project VBN cord-010119-t1x9gknd 3880 24 to to TO cord-010119-t1x9gknd 3880 25 be be VB cord-010119-t1x9gknd 3880 26 well well RB cord-010119-t1x9gknd 3880 27 above above IN cord-010119-t1x9gknd 3880 28 80 80 CD cord-010119-t1x9gknd 3880 29 % % NN cord-010119-t1x9gknd 3880 30 and and CC cord-010119-t1x9gknd 3880 31 the the DT cord-010119-t1x9gknd 3880 32 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3880 33 failure failure NN cord-010119-t1x9gknd 3880 34 rate rate NN cord-010119-t1x9gknd 3880 35 would would MD cord-010119-t1x9gknd 3880 36 be be VB cord-010119-t1x9gknd 3880 37 below below IN cord-010119-t1x9gknd 3880 38 10 10 CD cord-010119-t1x9gknd 3880 39 % % NN cord-010119-t1x9gknd 3880 40 of of IN cord-010119-t1x9gknd 3880 41 units unit NNS cord-010119-t1x9gknd 3880 42 tested test VBN cord-010119-t1x9gknd 3880 43 ; ; : cord-010119-t1x9gknd 3880 44 compliant compliant JJ cord-010119-t1x9gknd 3880 45 with with IN cord-010119-t1x9gknd 3880 46 regulatory regulatory JJ cord-010119-t1x9gknd 3880 47 standards standard NNS cord-010119-t1x9gknd 3880 48 . . . cord-010119-t1x9gknd 3881 1 Conclusion conclusion NN cord-010119-t1x9gknd 3881 2 : : : cord-010119-t1x9gknd 3882 1 The the DT cord-010119-t1x9gknd 3882 2 differences difference NNS cord-010119-t1x9gknd 3882 3 between between IN cord-010119-t1x9gknd 3882 4 groups group NNS cord-010119-t1x9gknd 3882 5 in in IN cord-010119-t1x9gknd 3882 6 the the DT cord-010119-t1x9gknd 3882 7 cryopreserved cryopreserved JJ cord-010119-t1x9gknd 3882 8 RCC RCC NNP cord-010119-t1x9gknd 3882 9 physical physical JJ cord-010119-t1x9gknd 3882 10 characteristics characteristic NNS cord-010119-t1x9gknd 3882 11 were be VBD cord-010119-t1x9gknd 3882 12 expected expect VBN cord-010119-t1x9gknd 3882 13 due due IN cord-010119-t1x9gknd 3882 14 to to IN cord-010119-t1x9gknd 3882 15 the the DT cord-010119-t1x9gknd 3882 16 re re NN cord-010119-t1x9gknd 3882 17 - - NN cord-010119-t1x9gknd 3882 18 suspension suspension NN cord-010119-t1x9gknd 3882 19 method method NN cord-010119-t1x9gknd 3882 20 and and CC cord-010119-t1x9gknd 3882 21 differences difference NNS cord-010119-t1x9gknd 3882 22 in in IN cord-010119-t1x9gknd 3882 23 the the DT cord-010119-t1x9gknd 3882 24 input input NN cord-010119-t1x9gknd 3882 25 product product NN cord-010119-t1x9gknd 3882 26 red red JJ cord-010119-t1x9gknd 3882 27 cell cell NN cord-010119-t1x9gknd 3882 28 mass mass NN cord-010119-t1x9gknd 3882 29 . . . cord-010119-t1x9gknd 3883 1 The the DT cord-010119-t1x9gknd 3883 2 lack lack NN cord-010119-t1x9gknd 3883 3 of of IN cord-010119-t1x9gknd 3883 4 significant significant JJ cord-010119-t1x9gknd 3883 5 metabolic metabolic JJ cord-010119-t1x9gknd 3883 6 differences difference NNS cord-010119-t1x9gknd 3883 7 between between IN cord-010119-t1x9gknd 3883 8 groups group NNS cord-010119-t1x9gknd 3883 9 indicates indicate VBZ cord-010119-t1x9gknd 3883 10 that that IN cord-010119-t1x9gknd 3883 11 the the DT cord-010119-t1x9gknd 3883 12 differences difference NNS cord-010119-t1x9gknd 3883 13 in in IN cord-010119-t1x9gknd 3883 14 postdeglycerolization postdeglycerolization NN cord-010119-t1x9gknd 3883 15 hematocrits hematocrit NNS cord-010119-t1x9gknd 3883 16 are be VBP cord-010119-t1x9gknd 3883 17 not not RB cord-010119-t1x9gknd 3883 18 adversely adversely RB cord-010119-t1x9gknd 3883 19 affecting affect VBG cord-010119-t1x9gknd 3883 20 product product NN cord-010119-t1x9gknd 3883 21 quality quality NN cord-010119-t1x9gknd 3883 22 . . . cord-010119-t1x9gknd 3884 1 0.03 0.03 CD cord-010119-t1x9gknd 3884 2 6 6 CD cord-010119-t1x9gknd 3884 3 .02 .02 CD cord-010119-t1x9gknd 3884 4 0.33 0.33 CD cord-010119-t1x9gknd 3884 5 6 6 CD cord-010119-t1x9gknd 3884 6 .28 .28 CD cord-010119-t1x9gknd 3884 7 0.83 0.83 CD cord-010119-t1x9gknd 3884 8 6 6 CD cord-010119-t1x9gknd 3884 9 .3 .3 CD cord-010119-t1x9gknd 3884 10 0.32 0.32 CD cord-010119-t1x9gknd 3884 11 6 6 CD cord-010119-t1x9gknd 3884 12 .14 .14 . cord-010119-t1x9gknd 3885 1 Elongation elongation NN cord-010119-t1x9gknd 3885 2 index index NN cord-010119-t1x9gknd 3885 3 ( ( -LRB- cord-010119-t1x9gknd 3885 4 30 30 CD cord-010119-t1x9gknd 3885 5 Pa Pa NNP cord-010119-t1x9gknd 3885 6 ) ) -RRB- cord-010119-t1x9gknd 3885 7 0.602 0.602 CD cord-010119-t1x9gknd 3886 1 6 6 CD cord-010119-t1x9gknd 3886 2 .008 .008 CD cord-010119-t1x9gknd 3886 3 0.585 0.585 CD cord-010119-t1x9gknd 3886 4 6 6 CD cord-010119-t1x9gknd 3887 1 .017 .017 NFP cord-010119-t1x9gknd 3887 2 0.580 0.580 CD cord-010119-t1x9gknd 3887 3 6 6 CD cord-010119-t1x9gknd 3887 4 .017 .017 CD cord-010119-t1x9gknd 3887 5 0.578 0.578 CD cord-010119-t1x9gknd 3887 6 6 6 CD cord-010119-t1x9gknd 3888 1 .017 .017 . cord-010119-t1x9gknd 3889 1 This this DT cord-010119-t1x9gknd 3889 2 study study NN cord-010119-t1x9gknd 3889 3 is be VBZ cord-010119-t1x9gknd 3889 4 funded fund VBN cord-010119-t1x9gknd 3889 5 by by IN cord-010119-t1x9gknd 3889 6 Zimmer Zimmer NNP cord-010119-t1x9gknd 3889 7 Biomet Biomet NNP cord-010119-t1x9gknd 3889 8 . . . cord-010119-t1x9gknd 3890 1 ( ( -LRB- cord-010119-t1x9gknd 3890 2 Hasan Hasan NNP cord-010119-t1x9gknd 3890 3 1994 1994 CD cord-010119-t1x9gknd 3890 4 ) ) -RRB- cord-010119-t1x9gknd 3890 5 . . . cord-010119-t1x9gknd 3891 1 The the DT cord-010119-t1x9gknd 3891 2 objective objective NN cord-010119-t1x9gknd 3891 3 was be VBD cord-010119-t1x9gknd 3891 4 to to TO cord-010119-t1x9gknd 3891 5 determine determine VB cord-010119-t1x9gknd 3891 6 the the DT cord-010119-t1x9gknd 3891 7 effect effect NN cord-010119-t1x9gknd 3891 8 of of IN cord-010119-t1x9gknd 3891 9 RBC RBC NNP cord-010119-t1x9gknd 3891 10 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3891 11 on on IN cord-010119-t1x9gknd 3891 12 RBC RBC NNP cord-010119-t1x9gknd 3891 13 oxygen oxygen NN cord-010119-t1x9gknd 3891 14 release release NN cord-010119-t1x9gknd 3891 15 capacity capacity NN cord-010119-t1x9gknd 3891 16 ( ( -LRB- cord-010119-t1x9gknd 3891 17 ORC ORC NNP cord-010119-t1x9gknd 3891 18 ) ) -RRB- cord-010119-t1x9gknd 3891 19 and and CC cord-010119-t1x9gknd 3891 20 estimated estimate VBD cord-010119-t1x9gknd 3891 21 oxygen oxygen NN cord-010119-t1x9gknd 3891 22 consumption consumption NN cord-010119-t1x9gknd 3891 23 ( ( -LRB- cord-010119-t1x9gknd 3891 24 VO VO NNP cord-010119-t1x9gknd 3891 25 2 2 CD cord-010119-t1x9gknd 3891 26 ) ) -RRB- cord-010119-t1x9gknd 3891 27 after after IN cord-010119-t1x9gknd 3891 28 simulating simulate VBG cord-010119-t1x9gknd 3891 29 a a DT cord-010119-t1x9gknd 3891 30 single single JJ cord-010119-t1x9gknd 3891 31 unit unit NN cord-010119-t1x9gknd 3891 32 transfusion transfusion NN cord-010119-t1x9gknd 3891 33 of of IN cord-010119-t1x9gknd 3891 34 either either DT cord-010119-t1x9gknd 3891 35 standard standard JJ cord-010119-t1x9gknd 3891 36 or or CC cord-010119-t1x9gknd 3891 37 rejuvenated rejuvenate VBN cord-010119-t1x9gknd 3891 38 RBC RBC NNP cord-010119-t1x9gknd 3891 39 stored store VBN cord-010119-t1x9gknd 3891 40 for for IN cord-010119-t1x9gknd 3891 41 42 42 CD cord-010119-t1x9gknd 3891 42 days day NNS cord-010119-t1x9gknd 3891 43 . . . cord-010119-t1x9gknd 3892 1 Study Study NNP cord-010119-t1x9gknd 3892 2 Design Design NNP cord-010119-t1x9gknd 3892 3 / / SYM cord-010119-t1x9gknd 3892 4 Method method NN cord-010119-t1x9gknd 3892 5 : : : cord-010119-t1x9gknd 3893 1 Oxygen oxygen NN cord-010119-t1x9gknd 3893 2 dissociation dissociation NN cord-010119-t1x9gknd 3893 3 curves curve NNS cord-010119-t1x9gknd 3893 4 ( ( -LRB- cord-010119-t1x9gknd 3893 5 ODC ODC NNP cord-010119-t1x9gknd 3893 6 ) ) -RRB- cord-010119-t1x9gknd 3894 1 ( ( -LRB- cord-010119-t1x9gknd 3894 2 Hemox Hemox NNP cord-010119-t1x9gknd 3894 3 Analyzer Analyzer NNP cord-010119-t1x9gknd 3894 4 , , , cord-010119-t1x9gknd 3894 5 TCS TCS NNP cord-010119-t1x9gknd 3894 6 Scientific Scientific NNP cord-010119-t1x9gknd 3894 7 ) ) -RRB- cord-010119-t1x9gknd 3894 8 were be VBD cord-010119-t1x9gknd 3894 9 generated generate VBN cord-010119-t1x9gknd 3894 10 from from IN cord-010119-t1x9gknd 3894 11 fifty fifty CD cord-010119-t1x9gknd 3894 12 - - HYPH cord-010119-t1x9gknd 3894 13 two two CD cord-010119-t1x9gknd 3894 14 ( ( -LRB- cord-010119-t1x9gknd 3894 15 52 52 CD cord-010119-t1x9gknd 3894 16 ) ) -RRB- cord-010119-t1x9gknd 3894 17 RBC RBC NNP cord-010119-t1x9gknd 3894 18 units unit NNS cord-010119-t1x9gknd 3894 19 ( ( -LRB- cord-010119-t1x9gknd 3894 20 leukocyte leukocyte NN cord-010119-t1x9gknd 3894 21 - - HYPH cord-010119-t1x9gknd 3894 22 reduced reduce VBN cord-010119-t1x9gknd 3894 23 ) ) -RRB- cord-010119-t1x9gknd 3894 24 , , , cord-010119-t1x9gknd 3894 25 CPD CPD NNP cord-010119-t1x9gknd 3894 26 / / SYM cord-010119-t1x9gknd 3894 27 AS-1 AS-1 NNP cord-010119-t1x9gknd 3894 28 or or CC cord-010119-t1x9gknd 3894 29 CP2D CP2D NNPS cord-010119-t1x9gknd 3894 30 / / SYM cord-010119-t1x9gknd 3894 31 AS-3 AS-3 NNP cord-010119-t1x9gknd 3894 32 , , , cord-010119-t1x9gknd 3894 33 on on IN cord-010119-t1x9gknd 3894 34 Day day NN cord-010119-t1x9gknd 3894 35 0 0 CD cord-010119-t1x9gknd 3894 36 , , , cord-010119-t1x9gknd 3894 37 Day Day NNP cord-010119-t1x9gknd 3894 38 42 42 CD cord-010119-t1x9gknd 3894 39 , , , cord-010119-t1x9gknd 3894 40 and and CC cord-010119-t1x9gknd 3894 41 after after IN cord-010119-t1x9gknd 3894 42 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3894 43 and and CC cord-010119-t1x9gknd 3894 44 washing washing NN cord-010119-t1x9gknd 3894 45 ( ( -LRB- cord-010119-t1x9gknd 3894 46 PW pw NN cord-010119-t1x9gknd 3894 47 ) ) -RRB- cord-010119-t1x9gknd 3894 48 . . . cord-010119-t1x9gknd 3895 1 The the DT cord-010119-t1x9gknd 3895 2 ODC ODC NNP cord-010119-t1x9gknd 3895 3 for for IN cord-010119-t1x9gknd 3895 4 each each DT cord-010119-t1x9gknd 3895 5 sample sample NN cord-010119-t1x9gknd 3895 6 was be VBD cord-010119-t1x9gknd 3895 7 used use VBN cord-010119-t1x9gknd 3895 8 to to TO cord-010119-t1x9gknd 3895 9 determine determine VB cord-010119-t1x9gknd 3895 10 ORC orc NN cord-010119-t1x9gknd 3895 11 ( ( -LRB- cord-010119-t1x9gknd 3895 12 mL ml NN cord-010119-t1x9gknd 3895 13 O o NN cord-010119-t1x9gknd 3895 14 2 2 CD cord-010119-t1x9gknd 3895 15 /g /g NNP cord-010119-t1x9gknd 3895 16 Hb Hb NNP cord-010119-t1x9gknd 3895 17 ) ) -RRB- cord-010119-t1x9gknd 3895 18 and and CC cord-010119-t1x9gknd 3895 19 Total Total NNP cord-010119-t1x9gknd 3895 20 Releasable Releasable NNP cord-010119-t1x9gknd 3895 21 Oxygen Oxygen NNP cord-010119-t1x9gknd 3895 22 ( ( -LRB- cord-010119-t1x9gknd 3895 23 TRO tro NN cord-010119-t1x9gknd 3895 24 ) ) -RRB- cord-010119-t1x9gknd 3895 25 of of IN cord-010119-t1x9gknd 3895 26 the the DT cord-010119-t1x9gknd 3895 27 unit unit NN cord-010119-t1x9gknd 3895 28 ( ( -LRB- cord-010119-t1x9gknd 3895 29 mL ml NN cord-010119-t1x9gknd 3895 30 O o NN cord-010119-t1x9gknd 3895 31 2 2 CD cord-010119-t1x9gknd 3895 32 ) ) -RRB- cord-010119-t1x9gknd 3895 33 . . . cord-010119-t1x9gknd 3896 1 ORC ORC NNP cord-010119-t1x9gknd 3896 2 was be VBD cord-010119-t1x9gknd 3896 3 determined determine VBN cord-010119-t1x9gknd 3896 4 by by IN cord-010119-t1x9gknd 3896 5 assessing assess VBG cord-010119-t1x9gknd 3896 6 the the DT cord-010119-t1x9gknd 3896 7 change change NN cord-010119-t1x9gknd 3896 8 in in IN cord-010119-t1x9gknd 3896 9 % % NN cord-010119-t1x9gknd 3896 10 O o NN cord-010119-t1x9gknd 3896 11 2 2 CD cord-010119-t1x9gknd 3896 12 saturation saturation NN cord-010119-t1x9gknd 3896 13 from from IN cord-010119-t1x9gknd 3896 14 100 100 CD cord-010119-t1x9gknd 3896 15 mm mm CD cord-010119-t1x9gknd 3896 16 Hg Hg NNP cord-010119-t1x9gknd 3896 17 PO PO NNP cord-010119-t1x9gknd 3896 18 2 2 CD cord-010119-t1x9gknd 3896 19 ( ( -LRB- cord-010119-t1x9gknd 3896 20 e.g. e.g. RB cord-010119-t1x9gknd 3896 21 , , , cord-010119-t1x9gknd 3896 22 lung lung NN cord-010119-t1x9gknd 3896 23 ) ) -RRB- cord-010119-t1x9gknd 3896 24 to to IN cord-010119-t1x9gknd 3896 25 40 40 CD cord-010119-t1x9gknd 3896 26 mm mm NN cord-010119-t1x9gknd 3896 27 Hg Hg NNP cord-010119-t1x9gknd 3896 28 PO PO NNP cord-010119-t1x9gknd 3896 29 2 2 CD cord-010119-t1x9gknd 3896 30 ( ( -LRB- cord-010119-t1x9gknd 3896 31 e.g. e.g. RB cord-010119-t1x9gknd 3896 32 , , , cord-010119-t1x9gknd 3896 33 venous venous JJ cord-010119-t1x9gknd 3896 34 blood blood NN cord-010119-t1x9gknd 3896 35 ) ) -RRB- cord-010119-t1x9gknd 3896 36 multiplied multiply VBN cord-010119-t1x9gknd 3896 37 by by IN cord-010119-t1x9gknd 3896 38 1.34 1.34 CD cord-010119-t1x9gknd 3896 39 mL ml NN cord-010119-t1x9gknd 3897 1 O o UH cord-010119-t1x9gknd 3898 1 2 2 LS cord-010119-t1x9gknd 3898 2 /g /g NNP cord-010119-t1x9gknd 3898 3 Hb Hb NNP cord-010119-t1x9gknd 3898 4 ( ( -LRB- cord-010119-t1x9gknd 3898 5 Li Li NNP cord-010119-t1x9gknd 3898 6 2016 2016 CD cord-010119-t1x9gknd 3898 7 ) ) -RRB- cord-010119-t1x9gknd 3898 8 . . . cord-010119-t1x9gknd 3899 1 A a DT cord-010119-t1x9gknd 3899 2 simulated simulated JJ cord-010119-t1x9gknd 3899 3 baseline baseline NN cord-010119-t1x9gknd 3899 4 pretransfusion pretransfusion NN cord-010119-t1x9gknd 3899 5 VO VO NNP cord-010119-t1x9gknd 3899 6 2 2 CD cord-010119-t1x9gknd 3899 7 of of IN cord-010119-t1x9gknd 3899 8 115 115 CD cord-010119-t1x9gknd 3899 9 mL ml NN cord-010119-t1x9gknd 3899 10 O o NN cord-010119-t1x9gknd 3899 11 2 2 CD cord-010119-t1x9gknd 3899 12 /min /min : cord-010119-t1x9gknd 3899 13 was be VBD cord-010119-t1x9gknd 3899 14 estimated estimate VBN cord-010119-t1x9gknd 3899 15 using use VBG cord-010119-t1x9gknd 3899 16 the the DT cord-010119-t1x9gknd 3899 17 Day day NN cord-010119-t1x9gknd 3899 18 0 0 CD cord-010119-t1x9gknd 3899 19 ORC orc NN cord-010119-t1x9gknd 3899 20 and and CC cord-010119-t1x9gknd 3899 21 assuming assume VBG cord-010119-t1x9gknd 3899 22 a a DT cord-010119-t1x9gknd 3899 23 7 7 CD cord-010119-t1x9gknd 3899 24 g g NN cord-010119-t1x9gknd 3899 25 / / SYM cord-010119-t1x9gknd 3899 26 dL dl NN cord-010119-t1x9gknd 3899 27 transfusion transfusion NN cord-010119-t1x9gknd 3899 28 trigger trigger NN cord-010119-t1x9gknd 3899 29 with with IN cord-010119-t1x9gknd 3899 30 a a DT cord-010119-t1x9gknd 3899 31 cardiac cardiac JJ cord-010119-t1x9gknd 3899 32 output output NN cord-010119-t1x9gknd 3899 33 of of IN cord-010119-t1x9gknd 3899 34 5 5 CD cord-010119-t1x9gknd 3899 35 L l NN cord-010119-t1x9gknd 3899 36 / / SYM cord-010119-t1x9gknd 3899 37 min min NN cord-010119-t1x9gknd 3899 38 and and CC cord-010119-t1x9gknd 3899 39 5 5 CD cord-010119-t1x9gknd 3899 40 L l NN cord-010119-t1x9gknd 3899 41 blood blood NN cord-010119-t1x9gknd 3899 42 volume volume NN cord-010119-t1x9gknd 3899 43 . . . cord-010119-t1x9gknd 3900 1 Paired Paired NNP cord-010119-t1x9gknd 3900 2 Student Student NNP cord-010119-t1x9gknd 3900 3 's 's POS cord-010119-t1x9gknd 3900 4 t t NN cord-010119-t1x9gknd 3900 5 tests test NNS cord-010119-t1x9gknd 3900 6 were be VBD cord-010119-t1x9gknd 3900 7 used use VBN cord-010119-t1x9gknd 3900 8 for for IN cord-010119-t1x9gknd 3900 9 comparative comparative JJ cord-010119-t1x9gknd 3900 10 statistical statistical JJ cord-010119-t1x9gknd 3900 11 analyses analysis NNS cord-010119-t1x9gknd 3900 12 . . . cord-010119-t1x9gknd 3901 1 Results result NNS cord-010119-t1x9gknd 3901 2 / / SYM cord-010119-t1x9gknd 3901 3 Finding finding NN cord-010119-t1x9gknd 3901 4 : : : cord-010119-t1x9gknd 3902 1 RBC RBC NNP cord-010119-t1x9gknd 3902 2 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3902 3 on on IN cord-010119-t1x9gknd 3902 4 day day NN cord-010119-t1x9gknd 3902 5 42 42 CD cord-010119-t1x9gknd 3902 6 restored restore VBN cord-010119-t1x9gknd 3902 7 ORC orc NN cord-010119-t1x9gknd 3902 8 and and CC cord-010119-t1x9gknd 3902 9 TRO tro NN cord-010119-t1x9gknd 3902 10 to to IN cord-010119-t1x9gknd 3902 11 levels level NNS cord-010119-t1x9gknd 3902 12 greater great JJR cord-010119-t1x9gknd 3902 13 than than IN cord-010119-t1x9gknd 3902 14 Day day NN cord-010119-t1x9gknd 3902 15 0 0 CD cord-010119-t1x9gknd 3903 1 ( ( -LRB- cord-010119-t1x9gknd 3903 2 Table table NN cord-010119-t1x9gknd 3903 3 1 1 CD cord-010119-t1x9gknd 3903 4 ) ) -RRB- cord-010119-t1x9gknd 3903 5 . . . cord-010119-t1x9gknd 3904 1 ORC orc NN cord-010119-t1x9gknd 3904 2 of of IN cord-010119-t1x9gknd 3904 3 the the DT cord-010119-t1x9gknd 3904 4 rejuvenated rejuvenated JJ cord-010119-t1x9gknd 3904 5 unit unit NN cord-010119-t1x9gknd 3904 6 was be VBD cord-010119-t1x9gknd 3904 7 1.5 1.5 CD cord-010119-t1x9gknd 3904 8 6 6 CD cord-010119-t1x9gknd 3904 9 0.2 0.2 CD cord-010119-t1x9gknd 3904 10 times time NNS cord-010119-t1x9gknd 3904 11 and and CC cord-010119-t1x9gknd 3904 12 3.4 3.4 CD cord-010119-t1x9gknd 3904 13 6 6 CD cord-010119-t1x9gknd 3904 14 0.5 0.5 CD cord-010119-t1x9gknd 3904 15 times time NNS cord-010119-t1x9gknd 3904 16 greater great JJR cord-010119-t1x9gknd 3904 17 than than IN cord-010119-t1x9gknd 3904 18 RBC RBC NNP cord-010119-t1x9gknd 3904 19 on on IN cord-010119-t1x9gknd 3904 20 Day Day NNP cord-010119-t1x9gknd 3904 21 0 0 CD cord-010119-t1x9gknd 3904 22 and and CC cord-010119-t1x9gknd 3904 23 Day Day NNP cord-010119-t1x9gknd 3904 24 42 42 CD cord-010119-t1x9gknd 3904 25 , , , cord-010119-t1x9gknd 3904 26 respectively respectively RB cord-010119-t1x9gknd 3904 27 ( ( -LRB- cord-010119-t1x9gknd 3904 28 p<0.001 p<0.001 JJ cord-010119-t1x9gknd 3904 29 ) ) -RRB- cord-010119-t1x9gknd 3904 30 . . . cord-010119-t1x9gknd 3905 1 VO VO NNP cord-010119-t1x9gknd 3905 2 2 2 CD cord-010119-t1x9gknd 3905 3 increased increase VBD cord-010119-t1x9gknd 3905 4 after after IN cord-010119-t1x9gknd 3905 5 a a DT cord-010119-t1x9gknd 3905 6 simulated simulated JJ cord-010119-t1x9gknd 3905 7 single single JJ cord-010119-t1x9gknd 3905 8 unit unit NN cord-010119-t1x9gknd 3905 9 transfusion transfusion NN cord-010119-t1x9gknd 3905 10 of of IN cord-010119-t1x9gknd 3905 11 RBC RBC NNP cord-010119-t1x9gknd 3905 12 ( ( -LRB- cord-010119-t1x9gknd 3905 13 Day Day NNP cord-010119-t1x9gknd 3905 14 0 0 CD cord-010119-t1x9gknd 3905 15 , , , cord-010119-t1x9gknd 3905 16 Day Day NNP cord-010119-t1x9gknd 3905 17 42 42 CD cord-010119-t1x9gknd 3905 18 , , , cord-010119-t1x9gknd 3905 19 and and CC cord-010119-t1x9gknd 3905 20 PW pw NN cord-010119-t1x9gknd 3905 21 ) ) -RRB- cord-010119-t1x9gknd 3905 22 by by IN cord-010119-t1x9gknd 3905 23 19.3 19.3 CD cord-010119-t1x9gknd 3905 24 % % NN cord-010119-t1x9gknd 3905 25 , , , cord-010119-t1x9gknd 3905 26 8.9 8.9 CD cord-010119-t1x9gknd 3905 27 % % NN cord-010119-t1x9gknd 3905 28 , , , cord-010119-t1x9gknd 3905 29 and and CC cord-010119-t1x9gknd 3905 30 28.8 28.8 CD cord-010119-t1x9gknd 3905 31 % % NN cord-010119-t1x9gknd 3905 32 over over IN cord-010119-t1x9gknd 3905 33 the the DT cord-010119-t1x9gknd 3905 34 pre pre JJ cord-010119-t1x9gknd 3905 35 transfusion transfusion NN cord-010119-t1x9gknd 3905 36 VO VO NNP cord-010119-t1x9gknd 3905 37 2 2 CD cord-010119-t1x9gknd 3905 38 , , , cord-010119-t1x9gknd 3905 39 respectively respectively RB cord-010119-t1x9gknd 3905 40 ( ( -LRB- cord-010119-t1x9gknd 3905 41 p<0.001 p<0.001 JJ cord-010119-t1x9gknd 3905 42 ) ) -RRB- cord-010119-t1x9gknd 3905 43 . . . cord-010119-t1x9gknd 3906 1 Conclusion conclusion NN cord-010119-t1x9gknd 3906 2 : : : cord-010119-t1x9gknd 3907 1 These these DT cord-010119-t1x9gknd 3907 2 results result NNS cord-010119-t1x9gknd 3907 3 suggest suggest VBP cord-010119-t1x9gknd 3907 4 a a DT cord-010119-t1x9gknd 3907 5 transfusion transfusion NN cord-010119-t1x9gknd 3907 6 with with IN cord-010119-t1x9gknd 3907 7 rejuvenated rejuvenated JJ cord-010119-t1x9gknd 3907 8 RBCs rbc NNS cord-010119-t1x9gknd 3907 9 has have VBZ cord-010119-t1x9gknd 3907 10 the the DT cord-010119-t1x9gknd 3907 11 potential potential NN cord-010119-t1x9gknd 3907 12 to to TO cord-010119-t1x9gknd 3907 13 release release VB cord-010119-t1x9gknd 3907 14 3.3 3.3 CD cord-010119-t1x9gknd 3907 15 times time NNS cord-010119-t1x9gknd 3907 16 the the DT cord-010119-t1x9gknd 3907 17 volume volume NN cord-010119-t1x9gknd 3907 18 of of IN cord-010119-t1x9gknd 3907 19 O o NN cord-010119-t1x9gknd 3907 20 2 2 CD cord-010119-t1x9gknd 3907 21 compared compare VBN cord-010119-t1x9gknd 3907 22 to to IN cord-010119-t1x9gknd 3907 23 standard standard JJ cord-010119-t1x9gknd 3907 24 , , , cord-010119-t1x9gknd 3907 25 untreated untreated JJ cord-010119-t1x9gknd 3907 26 RBCs rbc NNS cord-010119-t1x9gknd 3907 27 stored store VBD cord-010119-t1x9gknd 3907 28 for for IN cord-010119-t1x9gknd 3907 29 42 42 CD cord-010119-t1x9gknd 3907 30 days day NNS cord-010119-t1x9gknd 3907 31 . . . cord-010119-t1x9gknd 3908 1 Inferior inferior JJ cord-010119-t1x9gknd 3908 2 oxygen oxygen NN cord-010119-t1x9gknd 3908 3 delivery delivery NN cord-010119-t1x9gknd 3908 4 to to IN cord-010119-t1x9gknd 3908 5 tissues tissue NNS cord-010119-t1x9gknd 3908 6 ( ( -LRB- cord-010119-t1x9gknd 3908 7 VO VO NNP cord-010119-t1x9gknd 3908 8 2 2 CD cord-010119-t1x9gknd 3908 9 max max NNP cord-010119-t1x9gknd 3908 10 ) ) -RRB- cord-010119-t1x9gknd 3908 11 has have VBZ cord-010119-t1x9gknd 3908 12 been be VBN cord-010119-t1x9gknd 3908 13 observed observe VBN cord-010119-t1x9gknd 3908 14 during during IN cord-010119-t1x9gknd 3908 15 exercise exercise NN cord-010119-t1x9gknd 3908 16 in in IN cord-010119-t1x9gknd 3908 17 healthy healthy JJ cord-010119-t1x9gknd 3908 18 human human JJ cord-010119-t1x9gknd 3908 19 volunteers volunteer NNS cord-010119-t1x9gknd 3908 20 after after IN cord-010119-t1x9gknd 3908 21 transfusion transfusion NN cord-010119-t1x9gknd 3908 22 of of IN cord-010119-t1x9gknd 3908 23 two two CD cord-010119-t1x9gknd 3908 24 autologous autologous JJ cord-010119-t1x9gknd 3908 25 RBC RBC NNP cord-010119-t1x9gknd 3908 26 units unit NNS cord-010119-t1x9gknd 3908 27 stored store VBN cord-010119-t1x9gknd 3908 28 for for IN cord-010119-t1x9gknd 3908 29 42 42 CD cord-010119-t1x9gknd 3908 30 days day NNS cord-010119-t1x9gknd 3908 31 vs vs IN cord-010119-t1x9gknd 3908 32 7 7 CD cord-010119-t1x9gknd 3908 33 days day NNS cord-010119-t1x9gknd 3908 34 which which WDT cord-010119-t1x9gknd 3908 35 seem seem VBP cord-010119-t1x9gknd 3908 36 dependent dependent JJ cord-010119-t1x9gknd 3908 37 on on IN cord-010119-t1x9gknd 3908 38 genetic genetic JJ cord-010119-t1x9gknd 3908 39 variability variability NN cord-010119-t1x9gknd 3908 40 and and CC cord-010119-t1x9gknd 3908 41 storage storage NN cord-010119-t1x9gknd 3908 42 time time NN cord-010119-t1x9gknd 3909 1 ( ( -LRB- cord-010119-t1x9gknd 3909 2 Bennett Bennett NNP cord-010119-t1x9gknd 3909 3 - - HYPH cord-010119-t1x9gknd 3909 4 Guerrero Guerrero NNP cord-010119-t1x9gknd 3909 5 2017 2017 CD cord-010119-t1x9gknd 3909 6 ) ) -RRB- cord-010119-t1x9gknd 3909 7 . . . cord-010119-t1x9gknd 3910 1 Therefore therefore RB cord-010119-t1x9gknd 3910 2 , , , cord-010119-t1x9gknd 3910 3 transfusion transfusion NN cord-010119-t1x9gknd 3910 4 practices practice NNS cord-010119-t1x9gknd 3910 5 to to TO cord-010119-t1x9gknd 3910 6 correct correct VB cord-010119-t1x9gknd 3910 7 anemia anemia NN cord-010119-t1x9gknd 3910 8 may may MD cord-010119-t1x9gknd 3910 9 be be VB cord-010119-t1x9gknd 3910 10 less less RBR cord-010119-t1x9gknd 3910 11 effective effective JJ cord-010119-t1x9gknd 3910 12 than than IN cord-010119-t1x9gknd 3910 13 intended intend VBN cord-010119-t1x9gknd 3910 14 due due IN cord-010119-t1x9gknd 3910 15 to to IN cord-010119-t1x9gknd 3910 16 the the DT cord-010119-t1x9gknd 3910 17 variable variable JJ cord-010119-t1x9gknd 3910 18 ORC orc NN cord-010119-t1x9gknd 3910 19 of of IN cord-010119-t1x9gknd 3910 20 standard standard NN cord-010119-t1x9gknd 3910 21 stored store VBN cord-010119-t1x9gknd 3910 22 RBC RBC NNP cord-010119-t1x9gknd 3910 23 units unit NNS cord-010119-t1x9gknd 3910 24 . . . cord-010119-t1x9gknd 3911 1 Transfusion transfusion NN cord-010119-t1x9gknd 3911 2 strategies strategy NNS cord-010119-t1x9gknd 3911 3 should should MD cord-010119-t1x9gknd 3911 4 consider consider VB cord-010119-t1x9gknd 3911 5 whether whether IN cord-010119-t1x9gknd 3911 6 the the DT cord-010119-t1x9gknd 3911 7 use use NN cord-010119-t1x9gknd 3911 8 of of IN cord-010119-t1x9gknd 3911 9 RBC RBC NNP cord-010119-t1x9gknd 3911 10 with with IN cord-010119-t1x9gknd 3911 11 increased increase VBN cord-010119-t1x9gknd 3911 12 ORC orc NN cord-010119-t1x9gknd 3911 13 may may MD cord-010119-t1x9gknd 3911 14 be be VB cord-010119-t1x9gknd 3911 15 physiologically physiologically RB cord-010119-t1x9gknd 3911 16 advantageous advantageous JJ cord-010119-t1x9gknd 3911 17 . . . cord-010119-t1x9gknd 3912 1 Disclosure disclosure NN cord-010119-t1x9gknd 3912 2 : : : cord-010119-t1x9gknd 3913 1 This this DT cord-010119-t1x9gknd 3913 2 study study NN cord-010119-t1x9gknd 3913 3 was be VBD cord-010119-t1x9gknd 3913 4 funded fund VBN cord-010119-t1x9gknd 3913 5 by by IN cord-010119-t1x9gknd 3913 6 Zimmer Zimmer NNP cord-010119-t1x9gknd 3913 7 Biomet Biomet NNP cord-010119-t1x9gknd 3913 8 . . . cord-010119-t1x9gknd 3914 1 Rejuvenation rejuvenation NN cord-010119-t1x9gknd 3914 2 Solution Solution NNP cord-010119-t1x9gknd 3914 3 as as IN cord-010119-t1x9gknd 3914 4 an an DT cord-010119-t1x9gknd 3914 5 Adjunct Adjunct NNP cord-010119-t1x9gknd 3914 6 Storage Storage NNP cord-010119-t1x9gknd 3914 7 Solution Solution NNP cord-010119-t1x9gknd 3914 8 Maintains maintain VBZ cord-010119-t1x9gknd 3914 9 Physiological physiological JJ cord-010119-t1x9gknd 3914 10 Hemoglobin hemoglobin NN cord-010119-t1x9gknd 3914 11 Oxygen Oxygen NNP cord-010119-t1x9gknd 3914 12 Affinity Affinity NNP cord-010119-t1x9gknd 3914 13 during during IN cord-010119-t1x9gknd 3914 14 RBC RBC NNP cord-010119-t1x9gknd 3914 15 Unit Unit NNP cord-010119-t1x9gknd 3914 16 Storage Storage NNP cord-010119-t1x9gknd 3915 1 Andrea Andrea NNP cord-010119-t1x9gknd 3915 2 Ansari Ansari NNP cord-010119-t1x9gknd 3916 1 * * NFP cord-010119-t1x9gknd 3916 2 1 1 CD cord-010119-t1x9gknd 3916 3 , , , cord-010119-t1x9gknd 3916 4 Jay Jay NNP cord-010119-t1x9gknd 3916 5 Srinivasan Srinivasan NNP cord-010119-t1x9gknd 3916 6 1 1 CD cord-010119-t1x9gknd 3916 7 , , , cord-010119-t1x9gknd 3916 8 Gustaaf Gustaaf NNP cord-010119-t1x9gknd 3916 9 de de NNP cord-010119-t1x9gknd 3916 10 Ridder Ridder NNP cord-010119-t1x9gknd 3916 11 2 2 CD cord-010119-t1x9gknd 3916 12 , , , cord-010119-t1x9gknd 3916 13 Alan Alan NNP cord-010119-t1x9gknd 3916 14 D. D. NNP cord-010119-t1x9gknd 3916 15 Gray Gray NNP cord-010119-t1x9gknd 3916 16 3 3 NNP cord-010119-t1x9gknd 3916 17 , , , cord-010119-t1x9gknd 3916 18 Matt Matt NNP cord-010119-t1x9gknd 3916 19 Landrigan Landrigan NNP cord-010119-t1x9gknd 3916 20 4 4 CD cord-010119-t1x9gknd 3916 21 , , , cord-010119-t1x9gknd 3916 22 Keaton Keaton NNP cord-010119-t1x9gknd 3916 23 Charles Charles NNP cord-010119-t1x9gknd 3916 24 Stoner Stoner NNP cord-010119-t1x9gknd 3916 25 5 5 CD cord-010119-t1x9gknd 3916 26 , , , cord-010119-t1x9gknd 3916 27 Angela Angela NNP cord-010119-t1x9gknd 3916 28 Crabtree Crabtree NNP cord-010119-t1x9gknd 3916 29 6 6 CD cord-010119-t1x9gknd 3916 30 , , , cord-010119-t1x9gknd 3916 31 Jessica Jessica NNP cord-010119-t1x9gknd 3916 32 Poisson Poisson NNP cord-010119-t1x9gknd 3916 33 7 7 CD cord-010119-t1x9gknd 3916 34 and and CC cord-010119-t1x9gknd 3916 35 Ian Ian NNP cord-010119-t1x9gknd 3916 36 Welsby Welsby NNP cord-010119-t1x9gknd 3916 37 8 8 CD cord-010119-t1x9gknd 3916 38 . . . cord-010119-t1x9gknd 3917 1 1 1 CD cord-010119-t1x9gknd 3917 2 Duke Duke NNP cord-010119-t1x9gknd 3917 3 University University NNP cord-010119-t1x9gknd 3917 4 School School NNP cord-010119-t1x9gknd 3917 5 of of IN cord-010119-t1x9gknd 3917 6 Medicine Medicine NNP cord-010119-t1x9gknd 3917 7 , , , cord-010119-t1x9gknd 3917 8 2 2 CD cord-010119-t1x9gknd 3917 9 Duke Duke NNP cord-010119-t1x9gknd 3917 10 Health Health NNP cord-010119-t1x9gknd 3917 11 Pathology Pathology NNP cord-010119-t1x9gknd 3917 12 , , , cord-010119-t1x9gknd 3917 13 3 3 CD cord-010119-t1x9gknd 3917 14 Citra Citra NNP cord-010119-t1x9gknd 3917 15 Labs Labs NNPS cord-010119-t1x9gknd 3917 16 , , , cord-010119-t1x9gknd 3917 17 a a DT cord-010119-t1x9gknd 3917 18 Zimmer Zimmer NNP cord-010119-t1x9gknd 3917 19 Biomet Biomet NNP cord-010119-t1x9gknd 3917 20 Company Company NNP cord-010119-t1x9gknd 3917 21 , , , cord-010119-t1x9gknd 3917 22 4 4 CD cord-010119-t1x9gknd 3917 23 Zimmer Zimmer NNP cord-010119-t1x9gknd 3917 24 Biomet Biomet NNP cord-010119-t1x9gknd 3917 25 , , , cord-010119-t1x9gknd 3917 26 5 5 CD cord-010119-t1x9gknd 3917 27 Duke Duke NNP cord-010119-t1x9gknd 3917 28 University University NNP cord-010119-t1x9gknd 3917 29 , , , cord-010119-t1x9gknd 3917 30 6 6 CD cord-010119-t1x9gknd 3917 31 Department Department NNP cord-010119-t1x9gknd 3917 32 of of IN cord-010119-t1x9gknd 3917 33 Pathology Pathology NNP cord-010119-t1x9gknd 3917 34 , , , cord-010119-t1x9gknd 3917 35 Durham Durham NNP cord-010119-t1x9gknd 3917 36 Veterans Veterans NNPS cord-010119-t1x9gknd 3917 37 Affairs Affairs NNP cord-010119-t1x9gknd 3917 38 Medical Medical NNP cord-010119-t1x9gknd 3917 39 Center Center NNP cord-010119-t1x9gknd 3917 40 , , , cord-010119-t1x9gknd 3917 41 7 7 CD cord-010119-t1x9gknd 3917 42 Duke Duke NNP cord-010119-t1x9gknd 3917 43 University University NNP cord-010119-t1x9gknd 3917 44 Hospital Hospital NNP cord-010119-t1x9gknd 3917 45 , , , cord-010119-t1x9gknd 3917 46 8 8 CD cord-010119-t1x9gknd 3917 47 Duke Duke NNP cord-010119-t1x9gknd 3917 48 University University NNP cord-010119-t1x9gknd 3917 49 Medical Medical NNP cord-010119-t1x9gknd 3917 50 Center Center NNP cord-010119-t1x9gknd 3917 51 Background Background NNP cord-010119-t1x9gknd 3917 52 / / SYM cord-010119-t1x9gknd 3917 53 Case Case NNP cord-010119-t1x9gknd 3917 54 Studies Studies NNPS cord-010119-t1x9gknd 3917 55 : : : cord-010119-t1x9gknd 3917 56 Deleterious deleterious JJ cord-010119-t1x9gknd 3917 57 changes change NNS cord-010119-t1x9gknd 3917 58 develop develop VBP cord-010119-t1x9gknd 3917 59 during during IN cord-010119-t1x9gknd 3917 60 the the DT cord-010119-t1x9gknd 3917 61 storage storage NN cord-010119-t1x9gknd 3917 62 of of IN cord-010119-t1x9gknd 3917 63 packed packed JJ cord-010119-t1x9gknd 3917 64 red red JJ cord-010119-t1x9gknd 3917 65 blood blood NN cord-010119-t1x9gknd 3917 66 cells cell NNS cord-010119-t1x9gknd 3917 67 ( ( -LRB- cord-010119-t1x9gknd 3917 68 RBCs rbc NNS cord-010119-t1x9gknd 3917 69 ) ) -RRB- cord-010119-t1x9gknd 3918 1 collectively collectively RB cord-010119-t1x9gknd 3918 2 called call VBN cord-010119-t1x9gknd 3918 3 the the DT cord-010119-t1x9gknd 3918 4 " " `` cord-010119-t1x9gknd 3918 5 storage storage NN cord-010119-t1x9gknd 3918 6 lesion lesion NN cord-010119-t1x9gknd 3918 7 " " '' cord-010119-t1x9gknd 3918 8 . . . cord-010119-t1x9gknd 3919 1 These these DT cord-010119-t1x9gknd 3919 2 include include VBP cord-010119-t1x9gknd 3919 3 altered alter VBN cord-010119-t1x9gknd 3919 4 membrane membrane NN cord-010119-t1x9gknd 3919 5 composition composition NN cord-010119-t1x9gknd 3919 6 and and CC cord-010119-t1x9gknd 3919 7 decreased decrease VBD cord-010119-t1x9gknd 3919 8 deformability deformability NN cord-010119-t1x9gknd 3919 9 , , , cord-010119-t1x9gknd 3919 10 increased increase VBN cord-010119-t1x9gknd 3919 11 in in IN cord-010119-t1x9gknd 3919 12 - - HYPH cord-010119-t1x9gknd 3919 13 bag bag NN cord-010119-t1x9gknd 3919 14 and and CC cord-010119-t1x9gknd 3919 15 post post JJ cord-010119-t1x9gknd 3919 16 - - JJ cord-010119-t1x9gknd 3919 17 transfusion transfusion JJ cord-010119-t1x9gknd 3919 18 hemolysis hemolysis NN cord-010119-t1x9gknd 3919 19 , , , cord-010119-t1x9gknd 3919 20 loss loss NN cord-010119-t1x9gknd 3919 21 of of IN cord-010119-t1x9gknd 3919 22 ATP ATP NNP cord-010119-t1x9gknd 3919 23 , , , cord-010119-t1x9gknd 3919 24 Snitrosohemoglobin Snitrosohemoglobin NNP cord-010119-t1x9gknd 3919 25 , , , cord-010119-t1x9gknd 3919 26 vasodilatory vasodilatory NN cord-010119-t1x9gknd 3919 27 capacity capacity NN cord-010119-t1x9gknd 3919 28 , , , cord-010119-t1x9gknd 3919 29 and and CC cord-010119-t1x9gknd 3919 30 cell cell NN cord-010119-t1x9gknd 3919 31 surface surface NN cord-010119-t1x9gknd 3919 32 PS PS NNP cord-010119-t1x9gknd 3919 33 expression expression NN cord-010119-t1x9gknd 3919 34 , , , cord-010119-t1x9gknd 3919 35 and and CC cord-010119-t1x9gknd 3919 36 depleted deplete VBN cord-010119-t1x9gknd 3919 37 2,3-diphosphoglycerate 2,3-diphosphoglycerate CD cord-010119-t1x9gknd 3919 38 ( ( -LRB- cord-010119-t1x9gknd 3919 39 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3919 40 ) ) -RRB- cord-010119-t1x9gknd 3919 41 . . . cord-010119-t1x9gknd 3920 1 The the DT cord-010119-t1x9gknd 3920 2 loss loss NN cord-010119-t1x9gknd 3920 3 of of IN cord-010119-t1x9gknd 3920 4 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3920 5 increases increase NNS cord-010119-t1x9gknd 3920 6 the the DT cord-010119-t1x9gknd 3920 7 oxygen oxygen NN cord-010119-t1x9gknd 3920 8 affinity affinity NN cord-010119-t1x9gknd 3920 9 of of IN cord-010119-t1x9gknd 3920 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3920 11 , , , cord-010119-t1x9gknd 3920 12 resulting result VBG cord-010119-t1x9gknd 3920 13 in in IN cord-010119-t1x9gknd 3920 14 lower low JJR cord-010119-t1x9gknd 3920 15 p50 p50 NN cord-010119-t1x9gknd 3920 16 ( ( -LRB- cord-010119-t1x9gknd 3920 17 partial partial JJ cord-010119-t1x9gknd 3920 18 pressure pressure NN cord-010119-t1x9gknd 3920 19 of of IN cord-010119-t1x9gknd 3920 20 oxygen oxygen NN cord-010119-t1x9gknd 3920 21 at at IN cord-010119-t1x9gknd 3920 22 50 50 CD cord-010119-t1x9gknd 3920 23 % % NN cord-010119-t1x9gknd 3920 24 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3920 25 saturation saturation NN cord-010119-t1x9gknd 3920 26 ) ) -RRB- cord-010119-t1x9gknd 3920 27 . . . cord-010119-t1x9gknd 3921 1 Decreased decrease VBN cord-010119-t1x9gknd 3921 2 p50 p50 NN cord-010119-t1x9gknd 3921 3 may may MD cord-010119-t1x9gknd 3921 4 negatively negatively RB cord-010119-t1x9gknd 3921 5 impact impact VB cord-010119-t1x9gknd 3921 6 the the DT cord-010119-t1x9gknd 3921 7 ability ability NN cord-010119-t1x9gknd 3921 8 for for IN cord-010119-t1x9gknd 3921 9 transfused transfused JJ cord-010119-t1x9gknd 3921 10 RBCs rbc NNS cord-010119-t1x9gknd 3921 11 to to TO cord-010119-t1x9gknd 3921 12 release release VB cord-010119-t1x9gknd 3921 13 oxygen oxygen NN cord-010119-t1x9gknd 3921 14 to to IN cord-010119-t1x9gknd 3921 15 peripheral peripheral JJ cord-010119-t1x9gknd 3921 16 tissues tissue NNS cord-010119-t1x9gknd 3921 17 . . . cord-010119-t1x9gknd 3922 1 An an DT cord-010119-t1x9gknd 3922 2 FDA FDA NNP cord-010119-t1x9gknd 3922 3 - - HYPH cord-010119-t1x9gknd 3922 4 approved approve VBN cord-010119-t1x9gknd 3922 5 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3922 6 solution solution NN cord-010119-t1x9gknd 3922 7 ( ( -LRB- cord-010119-t1x9gknd 3922 8 Citra Citra NNP cord-010119-t1x9gknd 3922 9 Labs Labs NNP cord-010119-t1x9gknd 3922 10 ) ) -RRB- cord-010119-t1x9gknd 3922 11 can can MD cord-010119-t1x9gknd 3922 12 restore restore VB cord-010119-t1x9gknd 3922 13 normal normal JJ cord-010119-t1x9gknd 3922 14 levels level NNS cord-010119-t1x9gknd 3922 15 of of IN cord-010119-t1x9gknd 3922 16 ATP ATP NNP cord-010119-t1x9gknd 3922 17 and and CC cord-010119-t1x9gknd 3922 18 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3922 19 , , , cord-010119-t1x9gknd 3922 20 normalizing normalize VBG cord-010119-t1x9gknd 3922 21 membrane membrane NN cord-010119-t1x9gknd 3922 22 function function NN cord-010119-t1x9gknd 3922 23 and and CC cord-010119-t1x9gknd 3922 24 oxygen oxygen NN cord-010119-t1x9gknd 3922 25 affinity affinity NN cord-010119-t1x9gknd 3922 26 , , , cord-010119-t1x9gknd 3922 27 respectively respectively RB cord-010119-t1x9gknd 3922 28 . . . cord-010119-t1x9gknd 3923 1 This this DT cord-010119-t1x9gknd 3923 2 process process NN cord-010119-t1x9gknd 3923 3 requires require VBZ cord-010119-t1x9gknd 3923 4 incubation incubation NN cord-010119-t1x9gknd 3923 5 at at IN cord-010119-t1x9gknd 3923 6 378C 378c CD cord-010119-t1x9gknd 3923 7 for for IN cord-010119-t1x9gknd 3923 8 an an DT cord-010119-t1x9gknd 3923 9 hour hour NN cord-010119-t1x9gknd 3923 10 , , , cord-010119-t1x9gknd 3923 11 an an DT cord-010119-t1x9gknd 3923 12 impractical impractical JJ cord-010119-t1x9gknd 3923 13 step step NN cord-010119-t1x9gknd 3923 14 in in IN cord-010119-t1x9gknd 3923 15 time time NN cord-010119-t1x9gknd 3923 16 - - HYPH cord-010119-t1x9gknd 3923 17 sensitive sensitive JJ cord-010119-t1x9gknd 3923 18 situations situation NNS cord-010119-t1x9gknd 3923 19 , , , cord-010119-t1x9gknd 3923 20 followed follow VBN cord-010119-t1x9gknd 3923 21 by by IN cord-010119-t1x9gknd 3923 22 washing washing NN cord-010119-t1x9gknd 3923 23 of of IN cord-010119-t1x9gknd 3923 24 the the DT cord-010119-t1x9gknd 3923 25 RBCs rbc NNS cord-010119-t1x9gknd 3923 26 . . . cord-010119-t1x9gknd 3924 1 We -PRON- PRP cord-010119-t1x9gknd 3924 2 tested test VBD cord-010119-t1x9gknd 3924 3 the the DT cord-010119-t1x9gknd 3924 4 hypothesis hypothesis NN cord-010119-t1x9gknd 3924 5 that that IN cord-010119-t1x9gknd 3924 6 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3924 7 without without IN cord-010119-t1x9gknd 3924 8 the the DT cord-010119-t1x9gknd 3924 9 incubation incubation NN cord-010119-t1x9gknd 3924 10 step step NN cord-010119-t1x9gknd 3924 11 ( ( -LRB- cord-010119-t1x9gknd 3924 12 " " `` cord-010119-t1x9gknd 3924 13 cold cold JJ cord-010119-t1x9gknd 3924 14 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3924 15 " " '' cord-010119-t1x9gknd 3924 16 ) ) -RRB- cord-010119-t1x9gknd 3924 17 could could MD cord-010119-t1x9gknd 3924 18 prevent prevent VB cord-010119-t1x9gknd 3924 19 or or CC cord-010119-t1x9gknd 3924 20 reverse reverse VB cord-010119-t1x9gknd 3924 21 changes change NNS cord-010119-t1x9gknd 3924 22 in in IN cord-010119-t1x9gknd 3924 23 oxygen oxygen NN cord-010119-t1x9gknd 3924 24 affinity affinity NN cord-010119-t1x9gknd 3924 25 , , , cord-010119-t1x9gknd 3924 26 deformability deformability NN cord-010119-t1x9gknd 3924 27 , , , cord-010119-t1x9gknd 3924 28 and and CC cord-010119-t1x9gknd 3924 29 susceptibility susceptibility NN cord-010119-t1x9gknd 3924 30 to to IN cord-010119-t1x9gknd 3924 31 hemolysis hemolysis NN cord-010119-t1x9gknd 3924 32 of of IN cord-010119-t1x9gknd 3924 33 RBCs rbc NNS cord-010119-t1x9gknd 3924 34 . . . cord-010119-t1x9gknd 3925 1 Study Study NNP cord-010119-t1x9gknd 3925 2 Design Design NNP cord-010119-t1x9gknd 3925 3 / / SYM cord-010119-t1x9gknd 3925 4 Method method NN cord-010119-t1x9gknd 3925 5 : : : cord-010119-t1x9gknd 3926 1 Eight eight CD cord-010119-t1x9gknd 3926 2 units unit NNS cord-010119-t1x9gknd 3926 3 of of IN cord-010119-t1x9gknd 3926 4 group group NN cord-010119-t1x9gknd 3926 5 A1 A1 NNP cord-010119-t1x9gknd 3926 6 , , , cord-010119-t1x9gknd 3926 7 leukoreduced leukoreduced NNP cord-010119-t1x9gknd 3926 8 PRBC PRBC NNP cord-010119-t1x9gknd 3926 9 stored store VBD cord-010119-t1x9gknd 3926 10 in in IN cord-010119-t1x9gknd 3926 11 AS-1 AS-1 NNP cord-010119-t1x9gknd 3926 12 were be VBD cord-010119-t1x9gknd 3926 13 obtained obtain VBN cord-010119-t1x9gknd 3926 14 from from IN cord-010119-t1x9gknd 3926 15 our -PRON- PRP$ cord-010119-t1x9gknd 3926 16 local local JJ cord-010119-t1x9gknd 3926 17 blood blood NN cord-010119-t1x9gknd 3926 18 center center NN cord-010119-t1x9gknd 3926 19 . . . cord-010119-t1x9gknd 3927 1 After after IN cord-010119-t1x9gknd 3927 2 3 3 CD cord-010119-t1x9gknd 3927 3 days day NNS cord-010119-t1x9gknd 3927 4 of of IN cord-010119-t1x9gknd 3927 5 storage storage NN cord-010119-t1x9gknd 3927 6 , , , cord-010119-t1x9gknd 3927 7 units unit NNS cord-010119-t1x9gknd 3927 8 were be VBD cord-010119-t1x9gknd 3927 9 divided divide VBN cord-010119-t1x9gknd 3927 10 into into IN cord-010119-t1x9gknd 3927 11 4 4 CD cord-010119-t1x9gknd 3927 12 separate separate JJ cord-010119-t1x9gknd 3927 13 aliquots aliquot NNS cord-010119-t1x9gknd 3927 14 : : : cord-010119-t1x9gknd 3927 15 control control NN cord-010119-t1x9gknd 3927 16 ( ( -LRB- cord-010119-t1x9gknd 3927 17 CTL CTL NNP cord-010119-t1x9gknd 3927 18 ) ) -RRB- cord-010119-t1x9gknd 3927 19 , , , cord-010119-t1x9gknd 3927 20 wash wash NNP cord-010119-t1x9gknd 3927 21 ( ( -LRB- cord-010119-t1x9gknd 3927 22 W W NNP cord-010119-t1x9gknd 3927 23 ) ) -RRB- cord-010119-t1x9gknd 3927 24 , , , cord-010119-t1x9gknd 3927 25 standard standard JJ cord-010119-t1x9gknd 3927 26 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3927 27 ( ( -LRB- cord-010119-t1x9gknd 3927 28 SR SR NNP cord-010119-t1x9gknd 3927 29 ) ) -RRB- cord-010119-t1x9gknd 3927 30 , , , cord-010119-t1x9gknd 3927 31 and and CC cord-010119-t1x9gknd 3927 32 cold cold JJ cord-010119-t1x9gknd 3927 33 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3927 34 ( ( -LRB- cord-010119-t1x9gknd 3927 35 CR CR NNP cord-010119-t1x9gknd 3927 36 ) ) -RRB- cord-010119-t1x9gknd 3927 37 . . . cord-010119-t1x9gknd 3928 1 The the DT cord-010119-t1x9gknd 3928 2 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3928 3 solution solution NN cord-010119-t1x9gknd 3928 4 ( ( -LRB- cord-010119-t1x9gknd 3928 5 50ml 50ml NN cord-010119-t1x9gknd 3928 6 ) ) -RRB- cord-010119-t1x9gknd 3928 7 was be VBD cord-010119-t1x9gknd 3928 8 added add VBN cord-010119-t1x9gknd 3928 9 to to IN cord-010119-t1x9gknd 3928 10 the the DT cord-010119-t1x9gknd 3928 11 CR CR NNP cord-010119-t1x9gknd 3928 12 group group NN cord-010119-t1x9gknd 3928 13 , , , cord-010119-t1x9gknd 3928 14 and and CC cord-010119-t1x9gknd 3928 15 all all DT cord-010119-t1x9gknd 3928 16 groups group NNS cord-010119-t1x9gknd 3928 17 were be VBD cord-010119-t1x9gknd 3928 18 then then RB cord-010119-t1x9gknd 3928 19 stored store VBN cord-010119-t1x9gknd 3928 20 for for IN cord-010119-t1x9gknd 3928 21 another another DT cord-010119-t1x9gknd 3928 22 12 12 CD cord-010119-t1x9gknd 3928 23 days day NNS cord-010119-t1x9gknd 3928 24 at at IN cord-010119-t1x9gknd 3928 25 1 1 CD cord-010119-t1x9gknd 3928 26 - - : cord-010119-t1x9gknd 3928 27 68C. 68C. NNP cord-010119-t1x9gknd 3928 28 On on IN cord-010119-t1x9gknd 3928 29 day day NN cord-010119-t1x9gknd 3928 30 15 15 CD cord-010119-t1x9gknd 3928 31 of of IN cord-010119-t1x9gknd 3928 32 storage storage NN cord-010119-t1x9gknd 3928 33 , , , cord-010119-t1x9gknd 3928 34 the the DT cord-010119-t1x9gknd 3928 35 SR SR NNP cord-010119-t1x9gknd 3928 36 group group NN cord-010119-t1x9gknd 3928 37 was be VBD cord-010119-t1x9gknd 3928 38 incubated incubate VBN cord-010119-t1x9gknd 3928 39 for for IN cord-010119-t1x9gknd 3928 40 1 1 CD cord-010119-t1x9gknd 3928 41 hour hour NN cord-010119-t1x9gknd 3928 42 at at IN cord-010119-t1x9gknd 3928 43 378C 378c CD cord-010119-t1x9gknd 3928 44 with with IN cord-010119-t1x9gknd 3928 45 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3928 46 solution solution NN cord-010119-t1x9gknd 3928 47 , , , cord-010119-t1x9gknd 3928 48 after after IN cord-010119-t1x9gknd 3928 49 which which WDT cord-010119-t1x9gknd 3928 50 the the DT cord-010119-t1x9gknd 3928 51 W W NNP cord-010119-t1x9gknd 3928 52 , , , cord-010119-t1x9gknd 3928 53 SR SR NNP cord-010119-t1x9gknd 3928 54 , , , cord-010119-t1x9gknd 3928 55 and and CC cord-010119-t1x9gknd 3928 56 CR CR NNP cord-010119-t1x9gknd 3928 57 groups group NNS cord-010119-t1x9gknd 3928 58 were be VBD cord-010119-t1x9gknd 3928 59 separately separately RB cord-010119-t1x9gknd 3928 60 washed wash VBN cord-010119-t1x9gknd 3928 61 on on IN cord-010119-t1x9gknd 3928 62 a a DT cord-010119-t1x9gknd 3928 63 C.A.T.S c.a.t.s NN cord-010119-t1x9gknd 3928 64 V v NN cord-010119-t1x9gknd 3928 65 R r NN cord-010119-t1x9gknd 3928 66 ( ( -LRB- cord-010119-t1x9gknd 3928 67 Fresenius Fresenius NNP cord-010119-t1x9gknd 3928 68 Kabi Kabi NNP cord-010119-t1x9gknd 3928 69 ) ) -RRB- cord-010119-t1x9gknd 3928 70 using use VBG cord-010119-t1x9gknd 3928 71 the the DT cord-010119-t1x9gknd 3928 72 High High NNP cord-010119-t1x9gknd 3928 73 Quality quality NN cord-010119-t1x9gknd 3928 74 Wash wash NN cord-010119-t1x9gknd 3928 75 setting setting NN cord-010119-t1x9gknd 3928 76 . . . cord-010119-t1x9gknd 3929 1 Hemoglobin Hemoglobin NNP cord-010119-t1x9gknd 3929 2 p50 p50 NN cord-010119-t1x9gknd 3929 3 was be VBD cord-010119-t1x9gknd 3929 4 measured measure VBN cord-010119-t1x9gknd 3929 5 by by IN cord-010119-t1x9gknd 3929 6 tonometry tonometry NNP cord-010119-t1x9gknd 3929 7 using use VBG cord-010119-t1x9gknd 3929 8 a a DT cord-010119-t1x9gknd 3929 9 Hemox Hemox NNP cord-010119-t1x9gknd 3929 10 Analyzer Analyzer NNP cord-010119-t1x9gknd 3929 11 ( ( -LRB- cord-010119-t1x9gknd 3929 12 TCS TCS NNP cord-010119-t1x9gknd 3929 13 Scientific Scientific NNP cord-010119-t1x9gknd 3929 14 ) ) -RRB- cord-010119-t1x9gknd 3929 15 . . . cord-010119-t1x9gknd 3930 1 Deformability Deformability NNP cord-010119-t1x9gknd 3930 2 ( ( -LRB- cord-010119-t1x9gknd 3930 3 Elongation Elongation NNP cord-010119-t1x9gknd 3930 4 Index Index NNP cord-010119-t1x9gknd 3930 5 or or CC cord-010119-t1x9gknd 3930 6 EI EI NNP cord-010119-t1x9gknd 3930 7 ) ) -RRB- cord-010119-t1x9gknd 3930 8 was be VBD cord-010119-t1x9gknd 3930 9 measured measure VBN cord-010119-t1x9gknd 3930 10 by by IN cord-010119-t1x9gknd 3930 11 ektacytometry ektacytometry NNP cord-010119-t1x9gknd 3930 12 ( ( -LRB- cord-010119-t1x9gknd 3930 13 LoRRca LoRRca NNP cord-010119-t1x9gknd 3930 14 Mechatronics Mechatronics NNP cord-010119-t1x9gknd 3930 15 ) ) -RRB- cord-010119-t1x9gknd 3930 16 . . . cord-010119-t1x9gknd 3931 1 Supernatant supernatant JJ cord-010119-t1x9gknd 3931 2 plasma plasma NN cord-010119-t1x9gknd 3931 3 free free JJ cord-010119-t1x9gknd 3931 4 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3931 5 ( ( -LRB- cord-010119-t1x9gknd 3931 6 PFHb PFHb NNS cord-010119-t1x9gknd 3931 7 ) ) -RRB- cord-010119-t1x9gknd 3931 8 was be VBD cord-010119-t1x9gknd 3931 9 measured measure VBN cord-010119-t1x9gknd 3931 10 using use VBG cord-010119-t1x9gknd 3931 11 visiblelight visiblelight NN cord-010119-t1x9gknd 3931 12 spectrophotometry spectrophotometry NN cord-010119-t1x9gknd 3931 13 . . . cord-010119-t1x9gknd 3932 1 Cell cell NN cord-010119-t1x9gknd 3932 2 surface surface NN cord-010119-t1x9gknd 3932 3 PS PS NNP cord-010119-t1x9gknd 3932 4 expression expression NN cord-010119-t1x9gknd 3932 5 ( ( -LRB- cord-010119-t1x9gknd 3932 6 PS1 PS1 NNP cord-010119-t1x9gknd 3932 7 ) ) -RRB- cord-010119-t1x9gknd 3932 8 was be VBD cord-010119-t1x9gknd 3932 9 measured measure VBN cord-010119-t1x9gknd 3932 10 by by IN cord-010119-t1x9gknd 3932 11 Annexin Annexin NNP cord-010119-t1x9gknd 3932 12 V V NNP cord-010119-t1x9gknd 3932 13 flow flow NN cord-010119-t1x9gknd 3932 14 cytometry cytometry NN cord-010119-t1x9gknd 3932 15 . . . cord-010119-t1x9gknd 3933 1 All all DT cord-010119-t1x9gknd 3933 2 group group NN cord-010119-t1x9gknd 3933 3 results result NNS cord-010119-t1x9gknd 3933 4 were be VBD cord-010119-t1x9gknd 3933 5 compared compare VBN cord-010119-t1x9gknd 3933 6 using use VBG cord-010119-t1x9gknd 3933 7 nonparametric nonparametric JJ cord-010119-t1x9gknd 3933 8 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 3933 9 signed sign VBN cord-010119-t1x9gknd 3933 10 - - HYPH cord-010119-t1x9gknd 3933 11 rank rank NN cord-010119-t1x9gknd 3933 12 tests test NNS cord-010119-t1x9gknd 3933 13 with with IN cord-010119-t1x9gknd 3933 14 a a DT cord-010119-t1x9gknd 3933 15 5 5 CD cord-010119-t1x9gknd 3933 16 0.05 0.05 CD cord-010119-t1x9gknd 3933 17 . . . cord-010119-t1x9gknd 3934 1 Results/ Results/ . cord-010119-t1x9gknd 3935 1 Finding finding NN cord-010119-t1x9gknd 3935 2 : : : cord-010119-t1x9gknd 3936 1 Significant significant JJ cord-010119-t1x9gknd 3936 2 differences difference NNS cord-010119-t1x9gknd 3936 3 in in IN cord-010119-t1x9gknd 3936 4 p50 p50 NN cord-010119-t1x9gknd 3936 5 were be VBD cord-010119-t1x9gknd 3936 6 noticed notice VBN cord-010119-t1x9gknd 3936 7 between between IN cord-010119-t1x9gknd 3936 8 all all DT cord-010119-t1x9gknd 3936 9 groups group NNS cord-010119-t1x9gknd 3936 10 ( ( -LRB- cord-010119-t1x9gknd 3936 11 Table table NN cord-010119-t1x9gknd 3936 12 1 1 CD cord-010119-t1x9gknd 3936 13 ) ) -RRB- cord-010119-t1x9gknd 3936 14 . . . cord-010119-t1x9gknd 3937 1 EI EI NNP cord-010119-t1x9gknd 3937 2 , , , cord-010119-t1x9gknd 3937 3 PS1 PS1 NNP cord-010119-t1x9gknd 3937 4 , , , cord-010119-t1x9gknd 3937 5 and and CC cord-010119-t1x9gknd 3937 6 PFHb PFHb NNS cord-010119-t1x9gknd 3937 7 did do VBD cord-010119-t1x9gknd 3937 8 not not RB cord-010119-t1x9gknd 3937 9 differ differ VB cord-010119-t1x9gknd 3937 10 between between IN cord-010119-t1x9gknd 3937 11 groups group NNS cord-010119-t1x9gknd 3937 12 . . . cord-010119-t1x9gknd 3938 1 Conclusion conclusion NN cord-010119-t1x9gknd 3938 2 : : : cord-010119-t1x9gknd 3939 1 Cold cold JJ cord-010119-t1x9gknd 3939 2 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3939 3 prevents prevent VBZ cord-010119-t1x9gknd 3939 4 the the DT cord-010119-t1x9gknd 3939 5 increased increase VBN cord-010119-t1x9gknd 3939 6 oxygen oxygen NN cord-010119-t1x9gknd 3939 7 affinity affinity NN cord-010119-t1x9gknd 3939 8 ( ( -LRB- cord-010119-t1x9gknd 3939 9 lower low JJR cord-010119-t1x9gknd 3939 10 p50 p50 NN cord-010119-t1x9gknd 3939 11 ) ) -RRB- cord-010119-t1x9gknd 3939 12 seen see VBN cord-010119-t1x9gknd 3939 13 over over IN cord-010119-t1x9gknd 3939 14 15 15 CD cord-010119-t1x9gknd 3939 15 days day NNS cord-010119-t1x9gknd 3939 16 of of IN cord-010119-t1x9gknd 3939 17 RBC RBC NNP cord-010119-t1x9gknd 3939 18 storage storage NN cord-010119-t1x9gknd 3939 19 without without IN cord-010119-t1x9gknd 3939 20 adverse adverse JJ cord-010119-t1x9gknd 3939 21 effects effect NNS cord-010119-t1x9gknd 3939 22 on on IN cord-010119-t1x9gknd 3939 23 deformability deformability NN cord-010119-t1x9gknd 3939 24 or or CC cord-010119-t1x9gknd 3939 25 hemolysis hemolysis NN cord-010119-t1x9gknd 3939 26 . . . cord-010119-t1x9gknd 3940 1 This this DT cord-010119-t1x9gknd 3940 2 offers offer VBZ cord-010119-t1x9gknd 3940 3 an an DT cord-010119-t1x9gknd 3940 4 alternative alternative NN cord-010119-t1x9gknd 3940 5 to to IN cord-010119-t1x9gknd 3940 6 incubated incubate VBN cord-010119-t1x9gknd 3940 7 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3940 8 to to TO cord-010119-t1x9gknd 3940 9 provide provide VB cord-010119-t1x9gknd 3940 10 clinicians clinician NNS cord-010119-t1x9gknd 3940 11 with with IN cord-010119-t1x9gknd 3940 12 ready ready JJ cord-010119-t1x9gknd 3940 13 access access NN cord-010119-t1x9gknd 3940 14 to to IN cord-010119-t1x9gknd 3940 15 RBCs rbc NNS cord-010119-t1x9gknd 3940 16 with with IN cord-010119-t1x9gknd 3940 17 a a DT cord-010119-t1x9gknd 3940 18 high high JJ cord-010119-t1x9gknd 3940 19 / / SYM cord-010119-t1x9gknd 3940 20 normal normal JJ cord-010119-t1x9gknd 3940 21 p50 p50 NN cord-010119-t1x9gknd 3940 22 that that WDT cord-010119-t1x9gknd 3940 23 may may MD cord-010119-t1x9gknd 3940 24 better well RBR cord-010119-t1x9gknd 3940 25 release release VB cord-010119-t1x9gknd 3940 26 oxygen oxygen NN cord-010119-t1x9gknd 3940 27 to to IN cord-010119-t1x9gknd 3940 28 the the DT cord-010119-t1x9gknd 3940 29 tissues tissue NNS cord-010119-t1x9gknd 3940 30 . . . cord-010119-t1x9gknd 3941 1 cause cause VB cord-010119-t1x9gknd 3941 2 transient transient JJ cord-010119-t1x9gknd 3941 3 and and CC cord-010119-t1x9gknd 3941 4 potentially potentially RB cord-010119-t1x9gknd 3941 5 fatal fatal JJ cord-010119-t1x9gknd 3941 6 cardiac cardiac JJ cord-010119-t1x9gknd 3941 7 arrhythmias arrhythmia NNS cord-010119-t1x9gknd 3941 8 upon upon IN cord-010119-t1x9gknd 3941 9 transfusion transfusion NN cord-010119-t1x9gknd 3941 10 , , , cord-010119-t1x9gknd 3941 11 particularly particularly RB cord-010119-t1x9gknd 3941 12 in in IN cord-010119-t1x9gknd 3941 13 infants infant NNS cord-010119-t1x9gknd 3941 14 , , , cord-010119-t1x9gknd 3941 15 and and CC cord-010119-t1x9gknd 3941 16 massively massively RB cord-010119-t1x9gknd 3941 17 - - HYPH cord-010119-t1x9gknd 3941 18 transfused transfuse VBN cord-010119-t1x9gknd 3941 19 patients patient NNS cord-010119-t1x9gknd 3941 20 , , , cord-010119-t1x9gknd 3941 21 and and CC cord-010119-t1x9gknd 3941 22 those those DT cord-010119-t1x9gknd 3941 23 with with IN cord-010119-t1x9gknd 3941 24 compromised compromised JJ cord-010119-t1x9gknd 3941 25 renal renal JJ cord-010119-t1x9gknd 3941 26 function function NN cord-010119-t1x9gknd 3941 27 . . . cord-010119-t1x9gknd 3942 1 Reactive reactive JJ cord-010119-t1x9gknd 3942 2 antibodies antibody NNS cord-010119-t1x9gknd 3942 3 and and CC cord-010119-t1x9gknd 3942 4 other other JJ cord-010119-t1x9gknd 3942 5 inflammatory inflammatory JJ cord-010119-t1x9gknd 3942 6 agents agent NNS cord-010119-t1x9gknd 3942 7 in in IN cord-010119-t1x9gknd 3942 8 RBCs rbc NNS cord-010119-t1x9gknd 3942 9 can can MD cord-010119-t1x9gknd 3942 10 also also RB cord-010119-t1x9gknd 3942 11 elicit elicit VB cord-010119-t1x9gknd 3942 12 life life NN cord-010119-t1x9gknd 3942 13 - - HYPH cord-010119-t1x9gknd 3942 14 threatening threaten VBG cord-010119-t1x9gknd 3942 15 reactions reaction NNS cord-010119-t1x9gknd 3942 16 , , , cord-010119-t1x9gknd 3942 17 potentially potentially RB cord-010119-t1x9gknd 3942 18 causing cause VBG cord-010119-t1x9gknd 3942 19 high high JJ cord-010119-t1x9gknd 3942 20 fever fever NN cord-010119-t1x9gknd 3942 21 , , , cord-010119-t1x9gknd 3942 22 transfusion transfusion NN cord-010119-t1x9gknd 3942 23 - - HYPH cord-010119-t1x9gknd 3942 24 related relate VBN cord-010119-t1x9gknd 3942 25 acute acute JJ cord-010119-t1x9gknd 3942 26 lung lung NN cord-010119-t1x9gknd 3942 27 injury injury NN cord-010119-t1x9gknd 3942 28 ( ( -LRB- cord-010119-t1x9gknd 3942 29 TRALI TRALI NNP cord-010119-t1x9gknd 3942 30 ) ) -RRB- cord-010119-t1x9gknd 3942 31 , , , cord-010119-t1x9gknd 3942 32 anaphylaxis anaphylaxis NN cord-010119-t1x9gknd 3942 33 , , , cord-010119-t1x9gknd 3942 34 and and CC cord-010119-t1x9gknd 3942 35 even even RB cord-010119-t1x9gknd 3942 36 death death NN cord-010119-t1x9gknd 3942 37 . . . cord-010119-t1x9gknd 3943 1 In in IN cord-010119-t1x9gknd 3943 2 this this DT cord-010119-t1x9gknd 3943 3 study study NN cord-010119-t1x9gknd 3943 4 , , , cord-010119-t1x9gknd 3943 5 a a DT cord-010119-t1x9gknd 3943 6 multifunctional multifunctional JJ cord-010119-t1x9gknd 3943 7 bead bead NN cord-010119-t1x9gknd 3943 8 - - HYPH cord-010119-t1x9gknd 3943 9 based base VBN cord-010119-t1x9gknd 3943 10 filter filter NN cord-010119-t1x9gknd 3943 11 was be VBD cord-010119-t1x9gknd 3943 12 evaluated evaluate VBN cord-010119-t1x9gknd 3943 13 for for IN cord-010119-t1x9gknd 3943 14 removal removal NN cord-010119-t1x9gknd 3943 15 of of IN cord-010119-t1x9gknd 3943 16 K K NNP cord-010119-t1x9gknd 3943 17 1 1 CD cord-010119-t1x9gknd 3943 18 , , , cord-010119-t1x9gknd 3943 19 along along IN cord-010119-t1x9gknd 3943 20 with with IN cord-010119-t1x9gknd 3943 21 free free JJ cord-010119-t1x9gknd 3943 22 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3943 23 ( ( -LRB- cord-010119-t1x9gknd 3943 24 Hb Hb NNP cord-010119-t1x9gknd 3943 25 ) ) -RRB- cord-010119-t1x9gknd 3943 26 and and CC cord-010119-t1x9gknd 3943 27 other other JJ cord-010119-t1x9gknd 3943 28 pRBC prbc JJ cord-010119-t1x9gknd 3943 29 contaminants contaminant NNS cord-010119-t1x9gknd 3943 30 that that WDT cord-010119-t1x9gknd 3943 31 can can MD cord-010119-t1x9gknd 3943 32 contribute contribute VB cord-010119-t1x9gknd 3943 33 to to IN cord-010119-t1x9gknd 3943 34 transfusion transfusion NN cord-010119-t1x9gknd 3943 35 related relate VBN cord-010119-t1x9gknd 3943 36 adverse adverse JJ cord-010119-t1x9gknd 3943 37 events event NNS cord-010119-t1x9gknd 3943 38 . . . cord-010119-t1x9gknd 3944 1 Study Study NNP cord-010119-t1x9gknd 3944 2 Design Design NNP cord-010119-t1x9gknd 3944 3 / / SYM cord-010119-t1x9gknd 3944 4 Method method NN cord-010119-t1x9gknd 3944 5 : : : cord-010119-t1x9gknd 3944 6 Ten ten CD cord-010119-t1x9gknd 3944 7 leukocyte leukocyte NN cord-010119-t1x9gknd 3944 8 - - HYPH cord-010119-t1x9gknd 3944 9 reduced reduce VBN cord-010119-t1x9gknd 3944 10 pRBC pRBC NNS cord-010119-t1x9gknd 3944 11 ( ( -LRB- cord-010119-t1x9gknd 3944 12 300mL 300mL NNP cord-010119-t1x9gknd 3944 13 ) ) -RRB- cord-010119-t1x9gknd 3944 14 units unit NNS cord-010119-t1x9gknd 3944 15 stored store VBN cord-010119-t1x9gknd 3944 16 in in IN cord-010119-t1x9gknd 3944 17 AS-1 AS-1 NNP cord-010119-t1x9gknd 3944 18 , , , cord-010119-t1x9gknd 3944 19 obtained obtain VBN cord-010119-t1x9gknd 3944 20 from from IN cord-010119-t1x9gknd 3944 21 a a DT cord-010119-t1x9gknd 3944 22 regional regional JJ cord-010119-t1x9gknd 3944 23 blood blood NN cord-010119-t1x9gknd 3944 24 donor donor NN cord-010119-t1x9gknd 3944 25 center center NN cord-010119-t1x9gknd 3944 26 at at IN cord-010119-t1x9gknd 3944 27 expiration expiration NN cord-010119-t1x9gknd 3944 28 ( ( -LRB- cord-010119-t1x9gknd 3944 29 42 42 CD cord-010119-t1x9gknd 3944 30 6 6 CD cord-010119-t1x9gknd 3944 31 2 2 CD cord-010119-t1x9gknd 3944 32 days day NNS cord-010119-t1x9gknd 3944 33 ) ) -RRB- cord-010119-t1x9gknd 3944 34 , , , cord-010119-t1x9gknd 3944 35 were be VBD cord-010119-t1x9gknd 3944 36 passed pass VBN cord-010119-t1x9gknd 3944 37 by by IN cord-010119-t1x9gknd 3944 38 gravity gravity NN cord-010119-t1x9gknd 3944 39 through through IN cord-010119-t1x9gknd 3944 40 sorbent sorbent NN cord-010119-t1x9gknd 3944 41 - - HYPH cord-010119-t1x9gknd 3944 42 devices device NNS cord-010119-t1x9gknd 3944 43 containing contain VBG cord-010119-t1x9gknd 3944 44 50 50 CD cord-010119-t1x9gknd 3944 45 mL mL NNS cord-010119-t1x9gknd 3944 46 of of IN cord-010119-t1x9gknd 3944 47 multifunctional multifunctional JJ cord-010119-t1x9gknd 3944 48 polymer polymer NN cord-010119-t1x9gknd 3944 49 bead bead NN cord-010119-t1x9gknd 3944 50 , , , cord-010119-t1x9gknd 3944 51 at at IN cord-010119-t1x9gknd 3944 52 a a DT cord-010119-t1x9gknd 3944 53 flow flow NN cord-010119-t1x9gknd 3944 54 rate rate NN cord-010119-t1x9gknd 3944 55 of of IN cord-010119-t1x9gknd 3944 56 20 20 CD cord-010119-t1x9gknd 3944 57 mL ml NN cord-010119-t1x9gknd 3944 58 / / SYM cord-010119-t1x9gknd 3944 59 min min NN cord-010119-t1x9gknd 3944 60 . . . cord-010119-t1x9gknd 3945 1 Supernatants supernatant NNS cord-010119-t1x9gknd 3945 2 were be VBD cord-010119-t1x9gknd 3945 3 analyzed analyze VBN cord-010119-t1x9gknd 3945 4 for for IN cord-010119-t1x9gknd 3945 5 K K NNP cord-010119-t1x9gknd 3945 6 1 1 CD cord-010119-t1x9gknd 3945 7 removal removal NN cord-010119-t1x9gknd 3945 8 as as RB cord-010119-t1x9gknd 3945 9 well well RB cord-010119-t1x9gknd 3945 10 as as IN cord-010119-t1x9gknd 3945 11 free free JJ cord-010119-t1x9gknd 3945 12 Hb Hb NNP cord-010119-t1x9gknd 3945 13 , , , cord-010119-t1x9gknd 3945 14 antibodies antibody NNS cord-010119-t1x9gknd 3945 15 and and CC cord-010119-t1x9gknd 3945 16 cytokines cytokine NNS cord-010119-t1x9gknd 3945 17 ( ( -LRB- cord-010119-t1x9gknd 3945 18 27-plex 27-plex CD cord-010119-t1x9gknd 3945 19 , , , cord-010119-t1x9gknd 3945 20 BioRad BioRad NNP cord-010119-t1x9gknd 3945 21 ) ) -RRB- cord-010119-t1x9gknd 3945 22 . . . cord-010119-t1x9gknd 3946 1 RBCs rbc NNS cord-010119-t1x9gknd 3946 2 were be VBD cord-010119-t1x9gknd 3946 3 analyzed analyze VBN cord-010119-t1x9gknd 3946 4 for for IN cord-010119-t1x9gknd 3946 5 viability viability NN cord-010119-t1x9gknd 3946 6 and and CC cord-010119-t1x9gknd 3946 7 integrity integrity NN cord-010119-t1x9gknd 3946 8 via via IN cord-010119-t1x9gknd 3946 9 flow flow NN cord-010119-t1x9gknd 3946 10 cytometry cytometry NN cord-010119-t1x9gknd 3946 11 and and CC cord-010119-t1x9gknd 3946 12 osmotic osmotic JJ cord-010119-t1x9gknd 3946 13 fragility fragility NN cord-010119-t1x9gknd 3946 14 assay assay NN cord-010119-t1x9gknd 3946 15 , , , cord-010119-t1x9gknd 3946 16 respectively respectively RB cord-010119-t1x9gknd 3946 17 . . . cord-010119-t1x9gknd 3947 1 Results result NNS cord-010119-t1x9gknd 3948 1 /Finding /finde VBG cord-010119-t1x9gknd 3948 2 : : : cord-010119-t1x9gknd 3948 3 Filtration filtration NN cord-010119-t1x9gknd 3948 4 of of IN cord-010119-t1x9gknd 3948 5 the the DT cord-010119-t1x9gknd 3948 6 aged aged JJ cord-010119-t1x9gknd 3948 7 pRBC prbc JJ cord-010119-t1x9gknd 3948 8 units unit NNS cord-010119-t1x9gknd 3948 9 through through IN cord-010119-t1x9gknd 3948 10 the the DT cord-010119-t1x9gknd 3948 11 sorbent sorbent NN cord-010119-t1x9gknd 3948 12 device device NN cord-010119-t1x9gknd 3948 13 reduced reduce VBD cord-010119-t1x9gknd 3948 14 [ [ -LRB- cord-010119-t1x9gknd 3948 15 K K NNP cord-010119-t1x9gknd 3948 16 1 1 CD cord-010119-t1x9gknd 3948 17 ] ] -RRB- cord-010119-t1x9gknd 3948 18 from from IN cord-010119-t1x9gknd 3948 19 54.2 54.2 CD cord-010119-t1x9gknd 3948 20 6 6 CD cord-010119-t1x9gknd 3949 1 5.0 5.0 CD cord-010119-t1x9gknd 3949 2 to to TO cord-010119-t1x9gknd 3949 3 1.98 1.98 CD cord-010119-t1x9gknd 3949 4 6 6 CD cord-010119-t1x9gknd 3949 5 1.3 1.3 CD cord-010119-t1x9gknd 3949 6 mEq mEq NNS cord-010119-t1x9gknd 3949 7 / / SYM cord-010119-t1x9gknd 3949 8 L l NN cord-010119-t1x9gknd 3949 9 ; ; : cord-010119-t1x9gknd 3949 10 equivalent equivalent JJ cord-010119-t1x9gknd 3949 11 to to IN cord-010119-t1x9gknd 3949 12 an an DT cord-010119-t1x9gknd 3949 13 84.6 84.6 CD cord-010119-t1x9gknd 3949 14 % % NN cord-010119-t1x9gknd 3949 15 reduction reduction NN cord-010119-t1x9gknd 3949 16 . . . cord-010119-t1x9gknd 3950 1 Free Free NNP cord-010119-t1x9gknd 3950 2 Hb Hb NNP cord-010119-t1x9gknd 3950 3 was be VBD cord-010119-t1x9gknd 3950 4 reduced reduce VBN cord-010119-t1x9gknd 3950 5 by by IN cord-010119-t1x9gknd 3950 6 96.3 96.3 CD cord-010119-t1x9gknd 3950 7 % % NN cord-010119-t1x9gknd 3950 8 from from IN cord-010119-t1x9gknd 3950 9 2.5 2.5 CD cord-010119-t1x9gknd 3950 10 6 6 CD cord-010119-t1x9gknd 3950 11 1.0 1.0 CD cord-010119-t1x9gknd 3950 12 to to IN cord-010119-t1x9gknd 3950 13 0.39 0.39 CD cord-010119-t1x9gknd 3950 14 6 6 CD cord-010119-t1x9gknd 3950 15 0.2 0.2 CD cord-010119-t1x9gknd 3950 16 mg mg NNP cord-010119-t1x9gknd 3950 17 / / SYM cord-010119-t1x9gknd 3950 18 mL. mL. NNP cord-010119-t1x9gknd 3950 19 Antibodies Antibodies NNP cord-010119-t1x9gknd 3950 20 , , , cord-010119-t1x9gknd 3950 21 specifically specifically RB cord-010119-t1x9gknd 3950 22 IgG IgG NNP cord-010119-t1x9gknd 3950 23 , , , cord-010119-t1x9gknd 3950 24 IgA IgA NNP cord-010119-t1x9gknd 3950 25 , , , cord-010119-t1x9gknd 3950 26 and and CC cord-010119-t1x9gknd 3950 27 IgM IgM NNP cord-010119-t1x9gknd 3950 28 decreased decrease VBD cord-010119-t1x9gknd 3950 29 from from IN cord-010119-t1x9gknd 3950 30 9.91 9.91 CD cord-010119-t1x9gknd 3950 31 6 6 CD cord-010119-t1x9gknd 3950 32 3.1 3.1 CD cord-010119-t1x9gknd 3950 33 to to IN cord-010119-t1x9gknd 3950 34 2.40 2.40 CD cord-010119-t1x9gknd 3950 35 6 6 CD cord-010119-t1x9gknd 3950 36 1.1 1.1 CD cord-010119-t1x9gknd 3950 37 mg mg NNP cord-010119-t1x9gknd 3950 38 / / SYM cord-010119-t1x9gknd 3950 39 mL mL NNP cord-010119-t1x9gknd 3950 40 ( ( -LRB- cord-010119-t1x9gknd 3950 41 77.7 77.7 CD cord-010119-t1x9gknd 3950 42 % % NN cord-010119-t1x9gknd 3950 43 ) ) -RRB- cord-010119-t1x9gknd 3950 44 , , , cord-010119-t1x9gknd 3950 45 0.48 0.48 CD cord-010119-t1x9gknd 3950 46 6 6 CD cord-010119-t1x9gknd 3950 47 0.1 0.1 CD cord-010119-t1x9gknd 3950 48 to to IN cord-010119-t1x9gknd 3950 49 0.25 0.25 CD cord-010119-t1x9gknd 3950 50 6 6 CD cord-010119-t1x9gknd 3950 51 0.01 0.01 CD cord-010119-t1x9gknd 3950 52 mg mg NNP cord-010119-t1x9gknd 3950 53 / / SYM cord-010119-t1x9gknd 3950 54 mL mL NNP cord-010119-t1x9gknd 3950 55 ( ( -LRB- cord-010119-t1x9gknd 3950 56 48.9 48.9 CD cord-010119-t1x9gknd 3950 57 % % NN cord-010119-t1x9gknd 3950 58 ) ) -RRB- cord-010119-t1x9gknd 3950 59 , , , cord-010119-t1x9gknd 3950 60 and and CC cord-010119-t1x9gknd 3950 61 0.73 0.73 CD cord-010119-t1x9gknd 3950 62 6 6 CD cord-010119-t1x9gknd 3950 63 0.2 0.2 CD cord-010119-t1x9gknd 3950 64 to to IN cord-010119-t1x9gknd 3950 65 0.49 0.49 CD cord-010119-t1x9gknd 3950 66 6 6 CD cord-010119-t1x9gknd 3950 67 0.1 0.1 CD cord-010119-t1x9gknd 3950 68 mg mg NN cord-010119-t1x9gknd 3950 69 / / SYM cord-010119-t1x9gknd 3950 70 mL ml NN cord-010119-t1x9gknd 3950 71 ( ( -LRB- cord-010119-t1x9gknd 3950 72 31.5 31.5 CD cord-010119-t1x9gknd 3950 73 % % NN cord-010119-t1x9gknd 3950 74 ) ) -RRB- cord-010119-t1x9gknd 3950 75 , , , cord-010119-t1x9gknd 3950 76 respectively respectively RB cord-010119-t1x9gknd 3950 77 . . . cord-010119-t1x9gknd 3951 1 Inflammatory inflammatory JJ cord-010119-t1x9gknd 3951 2 cytokines cytokine NNS cord-010119-t1x9gknd 3951 3 were be VBD cord-010119-t1x9gknd 3951 4 significantly significantly RB cord-010119-t1x9gknd 3951 5 reduced reduce VBN cord-010119-t1x9gknd 3951 6 , , , cord-010119-t1x9gknd 3951 7 specifically specifically RB cord-010119-t1x9gknd 3951 8 : : : cord-010119-t1x9gknd 3951 9 IP-10 IP-10 NNP cord-010119-t1x9gknd 3951 10 from from IN cord-010119-t1x9gknd 3951 11 144.27 144.27 CD cord-010119-t1x9gknd 3951 12 6 6 CD cord-010119-t1x9gknd 3951 13 16.2 16.2 CD cord-010119-t1x9gknd 3951 14 to to IN cord-010119-t1x9gknd 3951 15 18.43 18.43 CD cord-010119-t1x9gknd 3951 16 6 6 CD cord-010119-t1x9gknd 3951 17 2.7 2.7 CD cord-010119-t1x9gknd 3951 18 pg pg NN cord-010119-t1x9gknd 3951 19 / / SYM cord-010119-t1x9gknd 3951 20 mL ml NN cord-010119-t1x9gknd 3951 21 ( ( -LRB- cord-010119-t1x9gknd 3951 22 87.2 87.2 CD cord-010119-t1x9gknd 3951 23 % % NN cord-010119-t1x9gknd 3951 24 ) ) -RRB- cord-010119-t1x9gknd 3952 1 , , , cord-010119-t1x9gknd 3952 2 MIP-1b MIP-1b NNP cord-010119-t1x9gknd 3952 3 from from IN cord-010119-t1x9gknd 3952 4 37.37 37.37 CD cord-010119-t1x9gknd 3952 5 6 6 CD cord-010119-t1x9gknd 3952 6 5.7 5.7 CD cord-010119-t1x9gknd 3952 7 to to IN cord-010119-t1x9gknd 3952 8 7.23 7.23 CD cord-010119-t1x9gknd 3952 9 6 6 CD cord-010119-t1x9gknd 3952 10 2.5 2.5 CD cord-010119-t1x9gknd 3952 11 pg pg NNS cord-010119-t1x9gknd 3952 12 / / SYM cord-010119-t1x9gknd 3952 13 mL mL NNP cord-010119-t1x9gknd 3952 14 ( ( -LRB- cord-010119-t1x9gknd 3952 15 80.7 80.7 CD cord-010119-t1x9gknd 3952 16 % % NN cord-010119-t1x9gknd 3952 17 ) ) -RRB- cord-010119-t1x9gknd 3952 18 , , , cord-010119-t1x9gknd 3952 19 and and CC cord-010119-t1x9gknd 3952 20 PDGF PDGF NNP cord-010119-t1x9gknd 3952 21 from from IN cord-010119-t1x9gknd 3952 22 1348.3 1348.3 CD cord-010119-t1x9gknd 3952 23 6 6 CD cord-010119-t1x9gknd 3952 24 291.9 291.9 CD cord-010119-t1x9gknd 3952 25 to to IN cord-010119-t1x9gknd 3952 26 77.91 77.91 CD cord-010119-t1x9gknd 3952 27 6 6 CD cord-010119-t1x9gknd 3952 28 22 22 CD cord-010119-t1x9gknd 3952 29 pg pg NN cord-010119-t1x9gknd 3952 30 / / SYM cord-010119-t1x9gknd 3952 31 mL ml NN cord-010119-t1x9gknd 3952 32 ( ( -LRB- cord-010119-t1x9gknd 3952 33 94.2 94.2 CD cord-010119-t1x9gknd 3952 34 % % NN cord-010119-t1x9gknd 3952 35 ) ) -RRB- cord-010119-t1x9gknd 3952 36 . . . cord-010119-t1x9gknd 3953 1 Filtration filtration NN cord-010119-t1x9gknd 3953 2 had have VBD cord-010119-t1x9gknd 3953 3 no no DT cord-010119-t1x9gknd 3953 4 significant significant JJ cord-010119-t1x9gknd 3953 5 impact impact NN cord-010119-t1x9gknd 3953 6 on on IN cord-010119-t1x9gknd 3953 7 cell cell NN cord-010119-t1x9gknd 3953 8 surface surface NN cord-010119-t1x9gknd 3953 9 markers marker NNS cord-010119-t1x9gknd 3953 10 of of IN cord-010119-t1x9gknd 3953 11 RBC RBC NNP cord-010119-t1x9gknd 3953 12 viability viability NN cord-010119-t1x9gknd 3953 13 ( ( -LRB- cord-010119-t1x9gknd 3953 14 < < XX cord-010119-t1x9gknd 3953 15 0.1 0.1 CD cord-010119-t1x9gknd 3953 16 % % NN cord-010119-t1x9gknd 3953 17 decrease decrease NN cord-010119-t1x9gknd 3953 18 ) ) -RRB- cord-010119-t1x9gknd 3953 19 or or CC cord-010119-t1x9gknd 3953 20 sensitivity sensitivity NN cord-010119-t1x9gknd 3953 21 to to IN cord-010119-t1x9gknd 3953 22 osmotic osmotic JJ cord-010119-t1x9gknd 3953 23 changes change NNS cord-010119-t1x9gknd 3953 24 . . . cord-010119-t1x9gknd 3954 1 Values value NNS cord-010119-t1x9gknd 3954 2 listed list VBN cord-010119-t1x9gknd 3954 3 represent represent VBP cord-010119-t1x9gknd 3955 1 mean mean VBP cord-010119-t1x9gknd 3955 2 6 6 CD cord-010119-t1x9gknd 3955 3 SEM sem NN cord-010119-t1x9gknd 3955 4 ( ( -LRB- cord-010119-t1x9gknd 3955 5 P p NN cord-010119-t1x9gknd 3955 6 < < XX cord-010119-t1x9gknd 3955 7 0.01 0.01 CD cord-010119-t1x9gknd 3955 8 for for IN cord-010119-t1x9gknd 3955 9 all all DT cord-010119-t1x9gknd 3955 10 analytes analyte NNS cord-010119-t1x9gknd 3955 11 tested test VBN cord-010119-t1x9gknd 3955 12 ) ) -RRB- cord-010119-t1x9gknd 3955 13 . . . cord-010119-t1x9gknd 3956 1 A a DT cord-010119-t1x9gknd 3956 2 paired paired JJ cord-010119-t1x9gknd 3956 3 ttest ttest NN cord-010119-t1x9gknd 3956 4 was be VBD cord-010119-t1x9gknd 3956 5 used use VBN cord-010119-t1x9gknd 3956 6 to to TO cord-010119-t1x9gknd 3956 7 assess assess VB cord-010119-t1x9gknd 3956 8 significance significance NN cord-010119-t1x9gknd 3956 9 . . . cord-010119-t1x9gknd 3957 1 Conclusion conclusion NN cord-010119-t1x9gknd 3957 2 : : : cord-010119-t1x9gknd 3958 1 The the DT cord-010119-t1x9gknd 3958 2 sorbent sorbent NN cord-010119-t1x9gknd 3958 3 filter filter NN cord-010119-t1x9gknd 3958 4 was be VBD cord-010119-t1x9gknd 3958 5 highly highly RB cord-010119-t1x9gknd 3958 6 effective effective JJ cord-010119-t1x9gknd 3958 7 in in IN cord-010119-t1x9gknd 3958 8 reducing reduce VBG cord-010119-t1x9gknd 3958 9 the the DT cord-010119-t1x9gknd 3958 10 levels level NNS cord-010119-t1x9gknd 3958 11 of of IN cord-010119-t1x9gknd 3958 12 extracellular extracellular JJ cord-010119-t1x9gknd 3958 13 K k NN cord-010119-t1x9gknd 3958 14 1 1 CD cord-010119-t1x9gknd 3958 15 as as RB cord-010119-t1x9gknd 3958 16 well well RB cord-010119-t1x9gknd 3958 17 as as IN cord-010119-t1x9gknd 3958 18 free free JJ cord-010119-t1x9gknd 3958 19 Hb Hb NNP cord-010119-t1x9gknd 3958 20 , , , cord-010119-t1x9gknd 3958 21 antibodies antibody NNS cord-010119-t1x9gknd 3958 22 , , , cord-010119-t1x9gknd 3958 23 and and CC cord-010119-t1x9gknd 3958 24 cytokines cytokine NNS cord-010119-t1x9gknd 3958 25 from from IN cord-010119-t1x9gknd 3958 26 pRBCs prbcs RB cord-010119-t1x9gknd 3958 27 without without IN cord-010119-t1x9gknd 3958 28 impact impact NN cord-010119-t1x9gknd 3958 29 on on IN cord-010119-t1x9gknd 3958 30 RBC RBC NNP cord-010119-t1x9gknd 3958 31 viability viability NN cord-010119-t1x9gknd 3958 32 or or CC cord-010119-t1x9gknd 3958 33 integrity integrity NN cord-010119-t1x9gknd 3958 34 . . . cord-010119-t1x9gknd 3959 1 This this DT cord-010119-t1x9gknd 3959 2 study study NN cord-010119-t1x9gknd 3959 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 3959 4 the the DT cord-010119-t1x9gknd 3959 5 viability viability NN cord-010119-t1x9gknd 3959 6 of of IN cord-010119-t1x9gknd 3959 7 a a DT cord-010119-t1x9gknd 3959 8 multifunctional multifunctional JJ cord-010119-t1x9gknd 3959 9 sorbent sorbent NN cord-010119-t1x9gknd 3959 10 filter filter NN cord-010119-t1x9gknd 3959 11 for for IN cord-010119-t1x9gknd 3959 12 removal removal NN cord-010119-t1x9gknd 3959 13 of of IN cord-010119-t1x9gknd 3959 14 K K NNP cord-010119-t1x9gknd 3959 15 1 1 CD cord-010119-t1x9gknd 3959 16 along along RB cord-010119-t1x9gknd 3959 17 with with IN cord-010119-t1x9gknd 3959 18 other other JJ cord-010119-t1x9gknd 3959 19 detrimental detrimental JJ cord-010119-t1x9gknd 3959 20 components component NNS cord-010119-t1x9gknd 3959 21 from from IN cord-010119-t1x9gknd 3959 22 stored store VBN cord-010119-t1x9gknd 3959 23 pRBCs prbcs RB cord-010119-t1x9gknd 3959 24 that that WDT cord-010119-t1x9gknd 3959 25 can can MD cord-010119-t1x9gknd 3959 26 readily readily RB cord-010119-t1x9gknd 3959 27 be be VB cord-010119-t1x9gknd 3959 28 incorporated incorporate VBN cord-010119-t1x9gknd 3959 29 into into IN cord-010119-t1x9gknd 3959 30 transfusion transfusion NN cord-010119-t1x9gknd 3959 31 practices practice NNS cord-010119-t1x9gknd 3959 32 to to TO cord-010119-t1x9gknd 3959 33 minimize minimize VB cord-010119-t1x9gknd 3959 34 adverse adverse JJ cord-010119-t1x9gknd 3959 35 effects effect NNS cord-010119-t1x9gknd 3959 36 . . . cord-010119-t1x9gknd 3960 1 Background Background NNP cord-010119-t1x9gknd 3960 2 / / SYM cord-010119-t1x9gknd 3960 3 Case Case NNP cord-010119-t1x9gknd 3960 4 Studies Studies NNPS cord-010119-t1x9gknd 3960 5 : : : cord-010119-t1x9gknd 3961 1 Platelets platelet NNS cord-010119-t1x9gknd 3961 2 carry carry VBP cord-010119-t1x9gknd 3961 3 no no DT cord-010119-t1x9gknd 3961 4 Rh Rh NNP cord-010119-t1x9gknd 3961 5 antigens antigen NNS cord-010119-t1x9gknd 3961 6 , , , cord-010119-t1x9gknd 3961 7 but but CC cord-010119-t1x9gknd 3961 8 residual residual JJ cord-010119-t1x9gknd 3961 9 red red JJ cord-010119-t1x9gknd 3961 10 blood blood NN cord-010119-t1x9gknd 3961 11 cell cell NN cord-010119-t1x9gknd 3961 12 ( ( -LRB- cord-010119-t1x9gknd 3961 13 RBC RBC NNP cord-010119-t1x9gknd 3961 14 ) ) -RRB- cord-010119-t1x9gknd 3961 15 in in IN cord-010119-t1x9gknd 3961 16 platelet platelet NN cord-010119-t1x9gknd 3961 17 products product NNS cord-010119-t1x9gknd 3961 18 can can MD cord-010119-t1x9gknd 3961 19 immunize immunize VB cord-010119-t1x9gknd 3961 20 D D NNP cord-010119-t1x9gknd 3961 21 negative negative JJ cord-010119-t1x9gknd 3961 22 recipients recipient NNS cord-010119-t1x9gknd 3961 23 if if IN cord-010119-t1x9gknd 3961 24 the the DT cord-010119-t1x9gknd 3961 25 donor donor NN cord-010119-t1x9gknd 3961 26 is be VBZ cord-010119-t1x9gknd 3961 27 D D NNP cord-010119-t1x9gknd 3961 28 positive positive JJ cord-010119-t1x9gknd 3961 29 . . . cord-010119-t1x9gknd 3962 1 Current current JJ cord-010119-t1x9gknd 3962 2 recommendation recommendation NN cord-010119-t1x9gknd 3962 3 is be VBZ cord-010119-t1x9gknd 3962 4 to to TO cord-010119-t1x9gknd 3962 5 give give VB cord-010119-t1x9gknd 3962 6 Rh Rh NNP cord-010119-t1x9gknd 3962 7 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 3962 8 ( ( -LRB- cord-010119-t1x9gknd 3962 9 RhIG rhig NN cord-010119-t1x9gknd 3962 10 ) ) -RRB- cord-010119-t1x9gknd 3962 11 to to IN cord-010119-t1x9gknd 3962 12 Rh Rh NNP cord-010119-t1x9gknd 3962 13 negative negative JJ cord-010119-t1x9gknd 3962 14 patient patient NN cord-010119-t1x9gknd 3962 15 if if IN cord-010119-t1x9gknd 3962 16 they -PRON- PRP cord-010119-t1x9gknd 3962 17 receive receive VBP cord-010119-t1x9gknd 3962 18 Rh Rh NNP cord-010119-t1x9gknd 3962 19 positive positive JJ cord-010119-t1x9gknd 3962 20 platelet platelet NN cord-010119-t1x9gknd 3962 21 unit unit NN cord-010119-t1x9gknd 3962 22 to to TO cord-010119-t1x9gknd 3962 23 avoid avoid VB cord-010119-t1x9gknd 3962 24 potential potential JJ cord-010119-t1x9gknd 3962 25 alloimmunization alloimmunization NN cord-010119-t1x9gknd 3962 26 to to IN cord-010119-t1x9gknd 3962 27 D D NNP cord-010119-t1x9gknd 3962 28 antigen antigen NN cord-010119-t1x9gknd 3962 29 . . . cord-010119-t1x9gknd 3963 1 A a DT cord-010119-t1x9gknd 3963 2 recent recent JJ cord-010119-t1x9gknd 3963 3 study study NN cord-010119-t1x9gknd 3963 4 has have VBZ cord-010119-t1x9gknd 3963 5 shown show VBN cord-010119-t1x9gknd 3963 6 a a DT cord-010119-t1x9gknd 3963 7 very very RB cord-010119-t1x9gknd 3963 8 low low JJ cord-010119-t1x9gknd 3963 9 frequency frequency NN cord-010119-t1x9gknd 3963 10 ( ( -LRB- cord-010119-t1x9gknd 3963 11 1.5 1.5 CD cord-010119-t1x9gknd 3963 12 % % NN cord-010119-t1x9gknd 3963 13 ) ) -RRB- cord-010119-t1x9gknd 3963 14 of of IN cord-010119-t1x9gknd 3963 15 D D NNP cord-010119-t1x9gknd 3963 16 alloimmunization alloimmunization NN cord-010119-t1x9gknd 3963 17 when when WRB cord-010119-t1x9gknd 3963 18 a a DT cord-010119-t1x9gknd 3963 19 Rh Rh NNP cord-010119-t1x9gknd 3963 20 mismatch mismatch NN cord-010119-t1x9gknd 3963 21 platelet platelet NN cord-010119-t1x9gknd 3963 22 is be VBZ cord-010119-t1x9gknd 3963 23 transfused transfuse VBN cord-010119-t1x9gknd 3963 24 . . . cord-010119-t1x9gknd 3964 1 Restricting restrict VBG cord-010119-t1x9gknd 3964 2 D d DT cord-010119-t1x9gknd 3964 3 negative negative JJ cord-010119-t1x9gknd 3964 4 patients patient NNS cord-010119-t1x9gknd 3964 5 to to TO cord-010119-t1x9gknd 3964 6 receive receive VB cord-010119-t1x9gknd 3964 7 only only RB cord-010119-t1x9gknd 3964 8 D d NN cord-010119-t1x9gknd 3964 9 negative negative JJ cord-010119-t1x9gknd 3964 10 platelets platelet NNS cord-010119-t1x9gknd 3964 11 could could MD cord-010119-t1x9gknd 3964 12 create create VB cord-010119-t1x9gknd 3964 13 shortage shortage NN cord-010119-t1x9gknd 3964 14 and and CC cord-010119-t1x9gknd 3964 15 cause cause VB cord-010119-t1x9gknd 3964 16 inventory inventory NN cord-010119-t1x9gknd 3964 17 challenges challenge NNS cord-010119-t1x9gknd 3964 18 . . . cord-010119-t1x9gknd 3965 1 Higher high JJR cord-010119-t1x9gknd 3965 2 yields yield NNS cord-010119-t1x9gknd 3965 3 of of IN cord-010119-t1x9gknd 3965 4 platelets platelet NNS cord-010119-t1x9gknd 3965 5 with with IN cord-010119-t1x9gknd 3965 6 minimum minimum NN cord-010119-t1x9gknd 3965 7 to to IN cord-010119-t1x9gknd 3965 8 none none NN cord-010119-t1x9gknd 3965 9 residual residual JJ cord-010119-t1x9gknd 3965 10 RBCs rbc NNS cord-010119-t1x9gknd 3965 11 are be VBP cord-010119-t1x9gknd 3965 12 obtained obtain VBN cord-010119-t1x9gknd 3965 13 with with IN cord-010119-t1x9gknd 3965 14 new new JJ cord-010119-t1x9gknd 3965 15 generations generation NNS cord-010119-t1x9gknd 3965 16 of of IN cord-010119-t1x9gknd 3965 17 apheresis apheresis NN cord-010119-t1x9gknd 3965 18 machines machine NNS cord-010119-t1x9gknd 3965 19 . . . cord-010119-t1x9gknd 3966 1 As as IN cord-010119-t1x9gknd 3966 2 a a DT cord-010119-t1x9gknd 3966 3 consequence consequence NN cord-010119-t1x9gknd 3966 4 , , , cord-010119-t1x9gknd 3966 5 the the DT cord-010119-t1x9gknd 3966 6 need need NN cord-010119-t1x9gknd 3966 7 for for IN cord-010119-t1x9gknd 3966 8 prophylactic prophylactic JJ cord-010119-t1x9gknd 3966 9 Rh Rh NNP cord-010119-t1x9gknd 3966 10 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 3966 11 ( ( -LRB- cord-010119-t1x9gknd 3966 12 RhIG RhIG NNP cord-010119-t1x9gknd 3966 13 ) ) -RRB- cord-010119-t1x9gknd 3966 14 may may MD cord-010119-t1x9gknd 3966 15 be be VB cord-010119-t1x9gknd 3966 16 unnecessary unnecessary JJ cord-010119-t1x9gknd 3966 17 with with IN cord-010119-t1x9gknd 3966 18 the the DT cord-010119-t1x9gknd 3966 19 use use NN cord-010119-t1x9gknd 3966 20 of of IN cord-010119-t1x9gknd 3966 21 apheresis apheresis NN cord-010119-t1x9gknd 3966 22 derived derive VBN cord-010119-t1x9gknd 3966 23 platelets platelet NNS cord-010119-t1x9gknd 3966 24 . . . cord-010119-t1x9gknd 3967 1 The the DT cord-010119-t1x9gknd 3967 2 accurate accurate JJ cord-010119-t1x9gknd 3967 3 determination determination NN cord-010119-t1x9gknd 3967 4 of of IN cord-010119-t1x9gknd 3967 5 residual residual JJ cord-010119-t1x9gknd 3967 6 RBC RBC NNP cord-010119-t1x9gknd 3967 7 in in IN cord-010119-t1x9gknd 3967 8 a a DT cord-010119-t1x9gknd 3967 9 platelet platelet NN cord-010119-t1x9gknd 3967 10 unit unit NN cord-010119-t1x9gknd 3967 11 is be VBZ cord-010119-t1x9gknd 3967 12 important important JJ cord-010119-t1x9gknd 3967 13 for for IN cord-010119-t1x9gknd 3967 14 patient patient JJ cord-010119-t1x9gknd 3967 15 safety safety NN cord-010119-t1x9gknd 3967 16 to to TO cord-010119-t1x9gknd 3967 17 prevent prevent VB cord-010119-t1x9gknd 3967 18 Rh Rh NNP cord-010119-t1x9gknd 3967 19 alloimmunization alloimmunization NN cord-010119-t1x9gknd 3967 20 . . . cord-010119-t1x9gknd 3968 1 Hemocytometer Hemocytometer NNP cord-010119-t1x9gknd 3968 2 is be VBZ cord-010119-t1x9gknd 3968 3 considered consider VBN cord-010119-t1x9gknd 3968 4 the the DT cord-010119-t1x9gknd 3968 5 gold gold NN cord-010119-t1x9gknd 3968 6 standard standard NN cord-010119-t1x9gknd 3968 7 for for IN cord-010119-t1x9gknd 3968 8 cell cell NN cord-010119-t1x9gknd 3968 9 counting counting NN cord-010119-t1x9gknd 3968 10 . . . cord-010119-t1x9gknd 3969 1 However however RB cord-010119-t1x9gknd 3969 2 , , , cord-010119-t1x9gknd 3969 3 the the DT cord-010119-t1x9gknd 3969 4 rapidity rapidity NN cord-010119-t1x9gknd 3969 5 and and CC cord-010119-t1x9gknd 3969 6 convenience convenience NN cord-010119-t1x9gknd 3969 7 offered offer VBN cord-010119-t1x9gknd 3969 8 by by IN cord-010119-t1x9gknd 3969 9 automated automate VBN cord-010119-t1x9gknd 3969 10 methods method NNS cord-010119-t1x9gknd 3969 11 resulted result VBN cord-010119-t1x9gknd 3969 12 in in IN cord-010119-t1x9gknd 3969 13 widespread widespread JJ cord-010119-t1x9gknd 3969 14 use use NN cord-010119-t1x9gknd 3969 15 of of IN cord-010119-t1x9gknd 3969 16 automated automate VBN cord-010119-t1x9gknd 3969 17 hematology hematology NN cord-010119-t1x9gknd 3969 18 analyzers analyzer NNS cord-010119-t1x9gknd 3969 19 . . . cord-010119-t1x9gknd 3970 1 Currently currently RB cord-010119-t1x9gknd 3970 2 there there EX cord-010119-t1x9gknd 3970 3 are be VBP cord-010119-t1x9gknd 3970 4 no no DT cord-010119-t1x9gknd 3970 5 standardization standardization NN cord-010119-t1x9gknd 3971 1 and/or and/or CC cord-010119-t1x9gknd 3971 2 guidelines guideline NNS cord-010119-t1x9gknd 3971 3 to to TO cord-010119-t1x9gknd 3971 4 advise advise VB cord-010119-t1x9gknd 3971 5 what what WP cord-010119-t1x9gknd 3971 6 system system NN cord-010119-t1x9gknd 3971 7 to to TO cord-010119-t1x9gknd 3971 8 use use VB cord-010119-t1x9gknd 3971 9 for for IN cord-010119-t1x9gknd 3971 10 RBC RBC NNP cord-010119-t1x9gknd 3971 11 quantification quantification NN cord-010119-t1x9gknd 3971 12 in in IN cord-010119-t1x9gknd 3971 13 platelet platelet NN cord-010119-t1x9gknd 3971 14 products product NNS cord-010119-t1x9gknd 3971 15 . . . cord-010119-t1x9gknd 3972 1 Study Study NNP cord-010119-t1x9gknd 3972 2 Design Design NNP cord-010119-t1x9gknd 3972 3 / / SYM cord-010119-t1x9gknd 3972 4 Method method NN cord-010119-t1x9gknd 3972 5 : : : cord-010119-t1x9gknd 3972 6 We -PRON- PRP cord-010119-t1x9gknd 3972 7 designed design VBD cord-010119-t1x9gknd 3972 8 this this DT cord-010119-t1x9gknd 3972 9 study study NN cord-010119-t1x9gknd 3972 10 to to TO cord-010119-t1x9gknd 3972 11 quantify quantify VB cord-010119-t1x9gknd 3972 12 the the DT cord-010119-t1x9gknd 3972 13 residual residual JJ cord-010119-t1x9gknd 3972 14 RBC RBC NNP cord-010119-t1x9gknd 3972 15 in in IN cord-010119-t1x9gknd 3972 16 apheresis apheresis NN cord-010119-t1x9gknd 3972 17 platelets platelet NNS cord-010119-t1x9gknd 3972 18 and and CC cord-010119-t1x9gknd 3972 19 whole whole JJ cord-010119-t1x9gknd 3972 20 blood blood NN cord-010119-t1x9gknd 3972 21 derived derive VBN cord-010119-t1x9gknd 3972 22 platelets platelet NNS cord-010119-t1x9gknd 3972 23 comparing compare VBG cord-010119-t1x9gknd 3972 24 hemocytometer hemocytometer NN cord-010119-t1x9gknd 3972 25 and and CC cord-010119-t1x9gknd 3972 26 automated automate VBN cord-010119-t1x9gknd 3972 27 methods method NNS cord-010119-t1x9gknd 3972 28 . . . cord-010119-t1x9gknd 3973 1 We -PRON- PRP cord-010119-t1x9gknd 3973 2 measured measure VBD cord-010119-t1x9gknd 3973 3 the the DT cord-010119-t1x9gknd 3973 4 amount amount NN cord-010119-t1x9gknd 3973 5 of of IN cord-010119-t1x9gknd 3973 6 red red JJ cord-010119-t1x9gknd 3973 7 blood blood NN cord-010119-t1x9gknd 3973 8 cells cell NNS cord-010119-t1x9gknd 3973 9 per per IN cord-010119-t1x9gknd 3973 10 microliter microliter NN cord-010119-t1x9gknd 3973 11 in in IN cord-010119-t1x9gknd 3973 12 50 50 CD cord-010119-t1x9gknd 3973 13 apheresis apheresis NN cord-010119-t1x9gknd 3973 14 and and CC cord-010119-t1x9gknd 3973 15 50 50 CD cord-010119-t1x9gknd 3973 16 whole whole JJ cord-010119-t1x9gknd 3973 17 blood blood NN cord-010119-t1x9gknd 3973 18 derived derive VBN cord-010119-t1x9gknd 3973 19 platelet platelet NN cord-010119-t1x9gknd 3973 20 units unit NNS cord-010119-t1x9gknd 3973 21 using use VBG cord-010119-t1x9gknd 3973 22 hemocytometer hemocytometer NN cord-010119-t1x9gknd 3973 23 and and CC cord-010119-t1x9gknd 3973 24 two two CD cord-010119-t1x9gknd 3973 25 different different JJ cord-010119-t1x9gknd 3973 26 automated automate VBN cord-010119-t1x9gknd 3973 27 hematology hematology NN cord-010119-t1x9gknd 3973 28 analyzers analyzer NNS cord-010119-t1x9gknd 3973 29 , , , cord-010119-t1x9gknd 3973 30 namely namely RB cord-010119-t1x9gknd 3973 31 , , , cord-010119-t1x9gknd 3973 32 Sysmex Sysmex NNP cord-010119-t1x9gknd 3973 33 ( ( -LRB- cord-010119-t1x9gknd 3973 34 Sysmex Sysmex NNP cord-010119-t1x9gknd 3973 35 America America NNP cord-010119-t1x9gknd 3973 36 , , , cord-010119-t1x9gknd 3973 37 Lincolnshire Lincolnshire NNP cord-010119-t1x9gknd 3973 38 , , , cord-010119-t1x9gknd 3973 39 IL IL NNP cord-010119-t1x9gknd 3973 40 ) ) -RRB- cord-010119-t1x9gknd 3973 41 and and CC cord-010119-t1x9gknd 3973 42 Advia Advia NNP cord-010119-t1x9gknd 3973 43 2120 2120 CD cord-010119-t1x9gknd 3973 44 ( ( -LRB- cord-010119-t1x9gknd 3973 45 Siemens Siemens NNP cord-010119-t1x9gknd 3973 46 Healthcare Healthcare NNP cord-010119-t1x9gknd 3973 47 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 3973 48 , , , cord-010119-t1x9gknd 3973 49 Tarrytown Tarrytown NNP cord-010119-t1x9gknd 3973 50 NY NY NNP cord-010119-t1x9gknd 3973 51 ) ) -RRB- cord-010119-t1x9gknd 3973 52 . . . cord-010119-t1x9gknd 3974 1 The the DT cord-010119-t1x9gknd 3974 2 whole whole JJ cord-010119-t1x9gknd 3974 3 blood blood NN cord-010119-t1x9gknd 3974 4 derived derive VBN cord-010119-t1x9gknd 3974 5 platelet platelet NN cord-010119-t1x9gknd 3974 6 units unit NNS cord-010119-t1x9gknd 3974 7 were be VBD cord-010119-t1x9gknd 3974 8 produced produce VBN cord-010119-t1x9gknd 3974 9 using use VBG cord-010119-t1x9gknd 3974 10 Acrodose Acrodose NNP cord-010119-t1x9gknd 3974 11 TM TM NNP cord-010119-t1x9gknd 3974 12 system system NN cord-010119-t1x9gknd 3974 13 technology technology NN cord-010119-t1x9gknd 3974 14 . . . cord-010119-t1x9gknd 3975 1 We -PRON- PRP cord-010119-t1x9gknd 3975 2 conducted conduct VBD cord-010119-t1x9gknd 3975 3 non non JJ cord-010119-t1x9gknd 3975 4 - - JJ cord-010119-t1x9gknd 3975 5 parametric parametric JJ cord-010119-t1x9gknd 3975 6 permutation permutation NN cord-010119-t1x9gknd 3975 7 test test NN cord-010119-t1x9gknd 3975 8 based base VBN cord-010119-t1x9gknd 3975 9 on on IN cord-010119-t1x9gknd 3975 10 10000 10000 CD cord-010119-t1x9gknd 3975 11 permutations permutation NNS cord-010119-t1x9gknd 3975 12 to to TO cord-010119-t1x9gknd 3975 13 compare compare VB cord-010119-t1x9gknd 3975 14 Sysmex Sysmex NNP cord-010119-t1x9gknd 3975 15 and and CC cord-010119-t1x9gknd 3975 16 Advia Advia NNP cord-010119-t1x9gknd 3975 17 between between IN cord-010119-t1x9gknd 3975 18 apheresis apheresis NN cord-010119-t1x9gknd 3975 19 and and CC cord-010119-t1x9gknd 3975 20 whole whole JJ cord-010119-t1x9gknd 3975 21 blood blood NN cord-010119-t1x9gknd 3975 22 derived derive VBN cord-010119-t1x9gknd 3975 23 groups group NNS cord-010119-t1x9gknd 3975 24 . . . cord-010119-t1x9gknd 3976 1 ABSTRACT abstract JJ cord-010119-t1x9gknd 3976 2 collection collection NN cord-010119-t1x9gknd 3976 3 ) ) -RRB- cord-010119-t1x9gknd 3976 4 RBCs rbc NNS cord-010119-t1x9gknd 3976 5 to to IN cord-010119-t1x9gknd 3976 6 RBCs rbc NNS cord-010119-t1x9gknd 3976 7 stored store VBN cord-010119-t1x9gknd 3976 8 for for IN cord-010119-t1x9gknd 3976 9 42 42 CD cord-010119-t1x9gknd 3976 10 days day NNS cord-010119-t1x9gknd 3976 11 and and CC cord-010119-t1x9gknd 3976 12 after after IN cord-010119-t1x9gknd 3976 13 treatment treatment NN cord-010119-t1x9gknd 3976 14 with with IN cord-010119-t1x9gknd 3976 15 an an DT cord-010119-t1x9gknd 3976 16 FDA FDA NNP cord-010119-t1x9gknd 3976 17 approved approve VBN cord-010119-t1x9gknd 3976 18 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3976 19 solution solution NN cord-010119-t1x9gknd 3976 20 . . . cord-010119-t1x9gknd 3977 1 Study Study NNP cord-010119-t1x9gknd 3977 2 Design Design NNP cord-010119-t1x9gknd 3977 3 / / SYM cord-010119-t1x9gknd 3977 4 Method method NN cord-010119-t1x9gknd 3977 5 : : : cord-010119-t1x9gknd 3978 1 The the DT cord-010119-t1x9gknd 3978 2 addition addition NN cord-010119-t1x9gknd 3978 3 of of IN cord-010119-t1x9gknd 3978 4 a a DT cord-010119-t1x9gknd 3978 5 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3978 6 solution solution NN cord-010119-t1x9gknd 3978 7 to to IN cord-010119-t1x9gknd 3978 8 stored store VBN cord-010119-t1x9gknd 3978 9 Red Red NNP cord-010119-t1x9gknd 3978 10 Blood Blood NNP cord-010119-t1x9gknd 3978 11 Cells cell NNS cord-010119-t1x9gknd 3978 12 ( ( -LRB- cord-010119-t1x9gknd 3978 13 RBCs rbc NNS cord-010119-t1x9gknd 3978 14 ) ) -RRB- cord-010119-t1x9gknd 3978 15 has have VBZ cord-010119-t1x9gknd 3978 16 been be VBN cord-010119-t1x9gknd 3978 17 shown show VBN cord-010119-t1x9gknd 3978 18 to to TO cord-010119-t1x9gknd 3978 19 increase increase VB cord-010119-t1x9gknd 3978 20 ATP ATP NNP cord-010119-t1x9gknd 3978 21 and and CC cord-010119-t1x9gknd 3978 22 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3978 23 profiles profile NNS cord-010119-t1x9gknd 3978 24 to to IN cord-010119-t1x9gknd 3978 25 fresh fresh JJ cord-010119-t1x9gknd 3978 26 levels level NNS cord-010119-t1x9gknd 3978 27 . . . cord-010119-t1x9gknd 3979 1 The the DT cord-010119-t1x9gknd 3979 2 objective objective NN cord-010119-t1x9gknd 3979 3 was be VBD cord-010119-t1x9gknd 3979 4 to to TO cord-010119-t1x9gknd 3979 5 compare compare VB cord-010119-t1x9gknd 3979 6 50 50 CD cord-010119-t1x9gknd 3979 7 % % NN cord-010119-t1x9gknd 3979 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 3979 9 - - HYPH cord-010119-t1x9gknd 3979 10 oxygen oxygen NN cord-010119-t1x9gknd 3979 11 saturation saturation NN cord-010119-t1x9gknd 3979 12 ( ( -LRB- cord-010119-t1x9gknd 3979 13 p50 p50 NN cord-010119-t1x9gknd 3979 14 ) ) -RRB- cord-010119-t1x9gknd 3979 15 and and CC cord-010119-t1x9gknd 3979 16 morphology morphology NN cord-010119-t1x9gknd 3979 17 profiles profile NNS cord-010119-t1x9gknd 3979 18 of of IN cord-010119-t1x9gknd 3979 19 fresh(day fresh(day NN cord-010119-t1x9gknd 3979 20 of of IN cord-010119-t1x9gknd 3979 21 collection collection NN cord-010119-t1x9gknd 3979 22 ) ) -RRB- cord-010119-t1x9gknd 3979 23 RBCs rbc NNS cord-010119-t1x9gknd 3979 24 to to IN cord-010119-t1x9gknd 3979 25 RBCs rbc NNS cord-010119-t1x9gknd 3979 26 stored store VBN cord-010119-t1x9gknd 3979 27 for for IN cord-010119-t1x9gknd 3979 28 42 42 CD cord-010119-t1x9gknd 3979 29 days day NNS cord-010119-t1x9gknd 3979 30 and and CC cord-010119-t1x9gknd 3979 31 after after IN cord-010119-t1x9gknd 3979 32 treatment treatment NN cord-010119-t1x9gknd 3979 33 with with IN cord-010119-t1x9gknd 3979 34 an an DT cord-010119-t1x9gknd 3979 35 FDA FDA NNP cord-010119-t1x9gknd 3979 36 approved approve VBN cord-010119-t1x9gknd 3979 37 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3979 38 solution solution NN cord-010119-t1x9gknd 3979 39 . . . cord-010119-t1x9gknd 3980 1 Results result NNS cord-010119-t1x9gknd 3980 2 / / SYM cord-010119-t1x9gknd 3980 3 Finding finding NN cord-010119-t1x9gknd 3980 4 : : : cord-010119-t1x9gknd 3981 1 In in IN cord-010119-t1x9gknd 3981 2 vitro vitro FW cord-010119-t1x9gknd 3981 3 RBC RBC NNP cord-010119-t1x9gknd 3981 4 recovery recovery NN cord-010119-t1x9gknd 3981 5 ( ( -LRB- cord-010119-t1x9gknd 3981 6 overall overall RB cord-010119-t1x9gknd 3981 7 ) ) -RRB- cord-010119-t1x9gknd 3981 8 was be VBD cord-010119-t1x9gknd 3981 9 97.2 97.2 CD cord-010119-t1x9gknd 3981 10 6 6 CD cord-010119-t1x9gknd 3981 11 2.2 2.2 CD cord-010119-t1x9gknd 3981 12 % % NN cord-010119-t1x9gknd 3981 13 . . . cord-010119-t1x9gknd 3982 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 3982 2 ( ( -LRB- cord-010119-t1x9gknd 3982 3 % % NN cord-010119-t1x9gknd 3982 4 ) ) -RRB- cord-010119-t1x9gknd 3982 5 was be VBD cord-010119-t1x9gknd 3982 6 similar similar JJ cord-010119-t1x9gknd 3982 7 on on IN cord-010119-t1x9gknd 3982 8 Day Day NNP cord-010119-t1x9gknd 3982 9 42 42 CD cord-010119-t1x9gknd 3982 10 before before RB cord-010119-t1x9gknd 3982 11 and and CC cord-010119-t1x9gknd 3982 12 after after IN cord-010119-t1x9gknd 3982 13 dry dry JJ cord-010119-t1x9gknd 3982 14 - - HYPH cord-010119-t1x9gknd 3982 15 air air NN cord-010119-t1x9gknd 3982 16 incubation incubation NN cord-010119-t1x9gknd 3982 17 with with IN cord-010119-t1x9gknd 3982 18 the the DT cord-010119-t1x9gknd 3982 19 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3982 20 solution solution NN cord-010119-t1x9gknd 3982 21 ( ( -LRB- cord-010119-t1x9gknd 3982 22 0.34 0.34 CD cord-010119-t1x9gknd 3982 23 6 6 CD cord-010119-t1x9gknd 3982 24 0.14 0.14 CD cord-010119-t1x9gknd 3982 25 % % NN cord-010119-t1x9gknd 3982 26 vs vs IN cord-010119-t1x9gknd 3982 27 0.35 0.35 CD cord-010119-t1x9gknd 3982 28 6 6 CD cord-010119-t1x9gknd 3982 29 0.14 0.14 CD cord-010119-t1x9gknd 3982 30 % % NN cord-010119-t1x9gknd 3982 31 ) ) -RRB- cord-010119-t1x9gknd 3982 32 . . . cord-010119-t1x9gknd 3983 1 Percent percent NN cord-010119-t1x9gknd 3983 2 hemolysis hemolysis NN cord-010119-t1x9gknd 3983 3 ( ( -LRB- cord-010119-t1x9gknd 3983 4 % % NN cord-010119-t1x9gknd 3983 5 ) ) -RRB- cord-010119-t1x9gknd 3983 6 decreased decrease VBD cord-010119-t1x9gknd 3983 7 after after IN cord-010119-t1x9gknd 3983 8 washing washing NN cord-010119-t1x9gknd 3983 9 ( ( -LRB- cord-010119-t1x9gknd 3983 10 0.24 0.24 CD cord-010119-t1x9gknd 3983 11 6 6 CD cord-010119-t1x9gknd 3983 12 0.07 0.07 CD cord-010119-t1x9gknd 3983 13 % % NN cord-010119-t1x9gknd 3983 14 ) ) -RRB- cord-010119-t1x9gknd 3983 15 and and CC cord-010119-t1x9gknd 3983 16 was be VBD cord-010119-t1x9gknd 3983 17 maintained maintain VBN cord-010119-t1x9gknd 3983 18 below below IN cord-010119-t1x9gknd 3983 19 < < XX cord-010119-t1x9gknd 3983 20 1 1 CD cord-010119-t1x9gknd 3983 21 % % NN cord-010119-t1x9gknd 3983 22 for for IN cord-010119-t1x9gknd 3983 23 all all DT cord-010119-t1x9gknd 3983 24 units unit NNS cord-010119-t1x9gknd 3983 25 during during IN cord-010119-t1x9gknd 3983 26 storage storage NN cord-010119-t1x9gknd 3983 27 for for IN cord-010119-t1x9gknd 3983 28 24Hr 24Hr NNP cord-010119-t1x9gknd 3983 29 ( ( -LRB- cord-010119-t1x9gknd 3983 30 0.51 0.51 CD cord-010119-t1x9gknd 3983 31 6 6 CD cord-010119-t1x9gknd 3983 32 0.19 0.19 CD cord-010119-t1x9gknd 3983 33 % % NN cord-010119-t1x9gknd 3983 34 ) ) -RRB- cord-010119-t1x9gknd 3983 35 . . . cord-010119-t1x9gknd 3984 1 Average average JJ cord-010119-t1x9gknd 3984 2 ATP ATP NNP cord-010119-t1x9gknd 3984 3 and and CC cord-010119-t1x9gknd 3984 4 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3984 5 were be VBD cord-010119-t1x9gknd 3984 6 restored restore VBN cord-010119-t1x9gknd 3984 7 above above IN cord-010119-t1x9gknd 3984 8 the the DT cord-010119-t1x9gknd 3984 9 average average JJ cord-010119-t1x9gknd 3984 10 fresh fresh JJ cord-010119-t1x9gknd 3984 11 values value NNS cord-010119-t1x9gknd 3984 12 . . . cord-010119-t1x9gknd 3985 1 The the DT cord-010119-t1x9gknd 3985 2 morphology morphology NN cord-010119-t1x9gknd 3985 3 score score NN cord-010119-t1x9gknd 3985 4 decreased decrease VBD cord-010119-t1x9gknd 3985 5 $ $ $ cord-010119-t1x9gknd 3985 6 25 25 CD cord-010119-t1x9gknd 3985 7 % % NN cord-010119-t1x9gknd 3985 8 by by IN cord-010119-t1x9gknd 3985 9 Day Day NNP cord-010119-t1x9gknd 3985 10 42 42 CD cord-010119-t1x9gknd 3985 11 , , , cord-010119-t1x9gknd 3985 12 which which WDT cord-010119-t1x9gknd 3985 13 was be VBD cord-010119-t1x9gknd 3985 14 restored restore VBN cord-010119-t1x9gknd 3985 15 to to IN cord-010119-t1x9gknd 3985 16 near near IN cord-010119-t1x9gknd 3985 17 fresh fresh JJ cord-010119-t1x9gknd 3985 18 values value NNS cord-010119-t1x9gknd 3985 19 following follow VBG cord-010119-t1x9gknd 3985 20 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3985 21 and and CC cord-010119-t1x9gknd 3985 22 washing washing NN cord-010119-t1x9gknd 3985 23 and and CC cord-010119-t1x9gknd 3985 24 storage storage NN cord-010119-t1x9gknd 3985 25 24Hr 24hr CD cord-010119-t1x9gknd 3985 26 ( ( -LRB- cord-010119-t1x9gknd 3985 27 93.7 93.7 CD cord-010119-t1x9gknd 3985 28 % % NN cord-010119-t1x9gknd 3985 29 and and CC cord-010119-t1x9gknd 3985 30 95.1 95.1 CD cord-010119-t1x9gknd 3985 31 % % NN cord-010119-t1x9gknd 3985 32 , , , cord-010119-t1x9gknd 3985 33 respectively respectively RB cord-010119-t1x9gknd 3985 34 ) ) -RRB- cord-010119-t1x9gknd 3985 35 . . . cord-010119-t1x9gknd 3986 1 RBC RBC NNP cord-010119-t1x9gknd 3986 2 oxygen oxygen NN cord-010119-t1x9gknd 3986 3 affinity affinity NN cord-010119-t1x9gknd 3986 4 , , , cord-010119-t1x9gknd 3986 5 as as IN cord-010119-t1x9gknd 3986 6 assessed assess VBN cord-010119-t1x9gknd 3986 7 by by IN cord-010119-t1x9gknd 3986 8 p50 p50 NN cord-010119-t1x9gknd 3986 9 , , , cord-010119-t1x9gknd 3986 10 was be VBD cord-010119-t1x9gknd 3986 11 restored restore VBN cord-010119-t1x9gknd 3986 12 above above IN cord-010119-t1x9gknd 3986 13 fresh fresh JJ cord-010119-t1x9gknd 3986 14 values value NNS cord-010119-t1x9gknd 3986 15 . . . cord-010119-t1x9gknd 3987 1 All all DT cord-010119-t1x9gknd 3987 2 values value NNS cord-010119-t1x9gknd 3987 3 were be VBD cord-010119-t1x9gknd 3987 4 significantly significantly RB cord-010119-t1x9gknd 3987 5 different different JJ cord-010119-t1x9gknd 3987 6 compared compare VBN cord-010119-t1x9gknd 3987 7 to to IN cord-010119-t1x9gknd 3987 8 Day Day NNP cord-010119-t1x9gknd 3987 9 42 42 CD cord-010119-t1x9gknd 3987 10 ( ( -LRB- cord-010119-t1x9gknd 3987 11 p<0.001 p<0.001 NNS cord-010119-t1x9gknd 3987 12 , , , cord-010119-t1x9gknd 3987 13 paired pair VBD cord-010119-t1x9gknd 3987 14 t t NN cord-010119-t1x9gknd 3987 15 - - HYPH cord-010119-t1x9gknd 3987 16 test test NN cord-010119-t1x9gknd 3987 17 ) ) -RRB- cord-010119-t1x9gknd 3988 1 ( ( -LRB- cord-010119-t1x9gknd 3988 2 Table table NN cord-010119-t1x9gknd 3988 3 1 1 CD cord-010119-t1x9gknd 3988 4 ) ) -RRB- cord-010119-t1x9gknd 3988 5 . . . cord-010119-t1x9gknd 3989 1 Conclusion conclusion NN cord-010119-t1x9gknd 3989 2 : : : cord-010119-t1x9gknd 3989 3 RBC RBC NNP cord-010119-t1x9gknd 3989 4 morphology morphology NN cord-010119-t1x9gknd 3989 5 was be VBD cord-010119-t1x9gknd 3989 6 restored restore VBN cord-010119-t1x9gknd 3989 7 to to IN cord-010119-t1x9gknd 3989 8 near near IN cord-010119-t1x9gknd 3989 9 fresh fresh JJ cord-010119-t1x9gknd 3989 10 and and CC cord-010119-t1x9gknd 3989 11 average average JJ cord-010119-t1x9gknd 3989 12 ATP ATP NNP cord-010119-t1x9gknd 3989 13 , , , cord-010119-t1x9gknd 3989 14 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3989 15 , , , cord-010119-t1x9gknd 3989 16 and and CC cord-010119-t1x9gknd 3989 17 p50 p50 NN cord-010119-t1x9gknd 3989 18 were be VBD cord-010119-t1x9gknd 3989 19 restored restore VBN cord-010119-t1x9gknd 3989 20 above above IN cord-010119-t1x9gknd 3989 21 fresh fresh JJ cord-010119-t1x9gknd 3989 22 values value NNS cord-010119-t1x9gknd 3989 23 when when WRB cord-010119-t1x9gknd 3989 24 incubated incubate VBN cord-010119-t1x9gknd 3989 25 with with IN cord-010119-t1x9gknd 3989 26 a a DT cord-010119-t1x9gknd 3989 27 rejuvenation rejuvenation NN cord-010119-t1x9gknd 3989 28 solution solution NN cord-010119-t1x9gknd 3989 29 using use VBG cord-010119-t1x9gknd 3989 30 the the DT cord-010119-t1x9gknd 3989 31 dry dry JJ cord-010119-t1x9gknd 3989 32 - - HYPH cord-010119-t1x9gknd 3989 33 air air NN cord-010119-t1x9gknd 3989 34 incubation incubation NN cord-010119-t1x9gknd 3989 35 process process NN cord-010119-t1x9gknd 3989 36 . . . cord-010119-t1x9gknd 3990 1 RBC RBC NNP cord-010119-t1x9gknd 3990 2 Morphology Morphology NNP cord-010119-t1x9gknd 3990 3 , , , cord-010119-t1x9gknd 3990 4 ATP ATP NNP cord-010119-t1x9gknd 3990 5 and and CC cord-010119-t1x9gknd 3990 6 2,3-DPG 2,3-dpg CD cord-010119-t1x9gknd 3990 7 were be VBD cord-010119-t1x9gknd 3990 8 maintained maintain VBN cord-010119-t1x9gknd 3990 9 during during IN cord-010119-t1x9gknd 3990 10 storage storage NN cord-010119-t1x9gknd 3990 11 24Hr 24Hr NNP cord-010119-t1x9gknd 3990 12 . . . cord-010119-t1x9gknd 3991 1 Rejuvenation rejuvenation NN cord-010119-t1x9gknd 3991 2 of of IN cord-010119-t1x9gknd 3991 3 refrigerated refrigerated JJ cord-010119-t1x9gknd 3991 4 RBCs rbc NNS cord-010119-t1x9gknd 3991 5 may may MD cord-010119-t1x9gknd 3991 6 offer offer VB cord-010119-t1x9gknd 3991 7 avenues avenue NNS cord-010119-t1x9gknd 3991 8 to to TO cord-010119-t1x9gknd 3991 9 improve improve VB cord-010119-t1x9gknd 3991 10 RBC RBC NNP cord-010119-t1x9gknd 3991 11 quality quality NN cord-010119-t1x9gknd 3991 12 prior prior RB cord-010119-t1x9gknd 3991 13 to to IN cord-010119-t1x9gknd 3991 14 transfusion transfusion NN cord-010119-t1x9gknd 3991 15 . . . cord-010119-t1x9gknd 3992 1 Vandi Vandi NNP cord-010119-t1x9gknd 3992 2 Ly Ly NNP cord-010119-t1x9gknd 3992 3 * * NFP cord-010119-t1x9gknd 3992 4 , , , cord-010119-t1x9gknd 3992 5 Dimath Dimath NNP cord-010119-t1x9gknd 3992 6 Alyemni Alyemni NNP cord-010119-t1x9gknd 3992 7 , , , cord-010119-t1x9gknd 3992 8 Warren Warren NNP cord-010119-t1x9gknd 3992 9 R R NNP cord-010119-t1x9gknd 3992 10 Korn Korn NNP cord-010119-t1x9gknd 3992 11 , , , cord-010119-t1x9gknd 3992 12 Matthew Matthew NNP cord-010119-t1x9gknd 3992 13 J J NNP cord-010119-t1x9gknd 3992 14 Brune Brune NNP cord-010119-t1x9gknd 3992 15 and and CC cord-010119-t1x9gknd 3992 16 Julie Julie NNP cord-010119-t1x9gknd 3992 17 Katz Katz NNP cord-010119-t1x9gknd 3992 18 Karp Karp NNP cord-010119-t1x9gknd 3992 19 . . . cord-010119-t1x9gknd 3993 1 Thomas Thomas NNP cord-010119-t1x9gknd 3993 2 Jefferson Jefferson NNP cord-010119-t1x9gknd 3993 3 University University NNP cord-010119-t1x9gknd 3993 4 Hospital Hospital NNP cord-010119-t1x9gknd 3993 5 Background Background NNP cord-010119-t1x9gknd 3993 6 / / SYM cord-010119-t1x9gknd 3993 7 Case Case NNP cord-010119-t1x9gknd 3993 8 Studies Studies NNPS cord-010119-t1x9gknd 3994 1 : : : cord-010119-t1x9gknd 3994 2 Blood blood NN cord-010119-t1x9gknd 3994 3 donors donor NNS cord-010119-t1x9gknd 3994 4 are be VBP cord-010119-t1x9gknd 3994 5 screened screen VBN cord-010119-t1x9gknd 3994 6 with with IN cord-010119-t1x9gknd 3994 7 a a DT cord-010119-t1x9gknd 3994 8 donor donor NN cord-010119-t1x9gknd 3994 9 history history NN cord-010119-t1x9gknd 3994 10 questionnaire questionnaire NN cord-010119-t1x9gknd 3994 11 that that WDT cord-010119-t1x9gknd 3994 12 includes include VBZ cord-010119-t1x9gknd 3994 13 questions question NNS cord-010119-t1x9gknd 3994 14 regarding regard VBG cord-010119-t1x9gknd 3994 15 behavioral behavioral JJ cord-010119-t1x9gknd 3994 16 risk risk NN cord-010119-t1x9gknd 3994 17 factors factor NNS cord-010119-t1x9gknd 3994 18 , , , cord-010119-t1x9gknd 3994 19 but but CC cord-010119-t1x9gknd 3994 20 none none NN cord-010119-t1x9gknd 3994 21 that that WDT cord-010119-t1x9gknd 3994 22 specifically specifically RB cord-010119-t1x9gknd 3994 23 screen screen VBP cord-010119-t1x9gknd 3994 24 for for IN cord-010119-t1x9gknd 3994 25 the the DT cord-010119-t1x9gknd 3994 26 use use NN cord-010119-t1x9gknd 3994 27 of of IN cord-010119-t1x9gknd 3994 28 marijuana marijuana NN cord-010119-t1x9gknd 3994 29 . . . cord-010119-t1x9gknd 3995 1 Therefore therefore RB cord-010119-t1x9gknd 3995 2 , , , cord-010119-t1x9gknd 3995 3 there there EX cord-010119-t1x9gknd 3995 4 is be VBZ cord-010119-t1x9gknd 3995 5 the the DT cord-010119-t1x9gknd 3995 6 theoretical theoretical JJ cord-010119-t1x9gknd 3995 7 possibility possibility NN cord-010119-t1x9gknd 3995 8 of of IN cord-010119-t1x9gknd 3995 9 transfer transfer NN cord-010119-t1x9gknd 3995 10 of of IN cord-010119-t1x9gknd 3995 11 active active JJ cord-010119-t1x9gknd 3995 12 cannabis cannabis NN cord-010119-t1x9gknd 3995 13 metabolites metabolite NNS cord-010119-t1x9gknd 3995 14 through through IN cord-010119-t1x9gknd 3995 15 transfusion transfusion NN cord-010119-t1x9gknd 3995 16 . . . cord-010119-t1x9gknd 3996 1 Donor donor NN cord-010119-t1x9gknd 3996 2 plasma plasma NN cord-010119-t1x9gknd 3996 3 collected collect VBD cord-010119-t1x9gknd 3996 4 at at IN cord-010119-t1x9gknd 3996 5 an an DT cord-010119-t1x9gknd 3996 6 urban urban JJ cord-010119-t1x9gknd 3996 7 , , , cord-010119-t1x9gknd 3996 8 hospital hospital NN cord-010119-t1x9gknd 3996 9 - - HYPH cord-010119-t1x9gknd 3996 10 based base VBN cord-010119-t1x9gknd 3996 11 blood blood NN cord-010119-t1x9gknd 3996 12 donor donor NN cord-010119-t1x9gknd 3996 13 center center NN cord-010119-t1x9gknd 3996 14 was be VBD cord-010119-t1x9gknd 3996 15 examined examine VBN cord-010119-t1x9gknd 3996 16 for for IN cord-010119-t1x9gknd 3996 17 the the DT cord-010119-t1x9gknd 3996 18 presence presence NN cord-010119-t1x9gknd 3996 19 of of IN cord-010119-t1x9gknd 3996 20 active active JJ cord-010119-t1x9gknd 3996 21 cannabis cannabis NN cord-010119-t1x9gknd 3996 22 metabolites metabolite NNS cord-010119-t1x9gknd 3996 23 , , , cord-010119-t1x9gknd 3996 24 D9tetrahydrocannabinol D9tetrahydrocannabinol NNP cord-010119-t1x9gknd 3996 25 ( ( -LRB- cord-010119-t1x9gknd 3996 26 THC THC NNP cord-010119-t1x9gknd 3996 27 ) ) -RRB- cord-010119-t1x9gknd 3996 28 and and CC cord-010119-t1x9gknd 3996 29 11-OH 11-oh CD cord-010119-t1x9gknd 3996 30 - - HYPH cord-010119-t1x9gknd 3996 31 D9-tetrahydrocannabinol d9-tetrahydrocannabinol CC cord-010119-t1x9gknd 3997 1 ( ( -LRB- cord-010119-t1x9gknd 3997 2 11-OH 11-oh CD cord-010119-t1x9gknd 3997 3 - - HYPH cord-010119-t1x9gknd 3997 4 THC thc NN cord-010119-t1x9gknd 3997 5 ) ) -RRB- cord-010119-t1x9gknd 3997 6 . . . cord-010119-t1x9gknd 3998 1 Study Study NNP cord-010119-t1x9gknd 3998 2 Design Design NNP cord-010119-t1x9gknd 3998 3 / / SYM cord-010119-t1x9gknd 3998 4 Method method NN cord-010119-t1x9gknd 3998 5 : : : cord-010119-t1x9gknd 3998 6 De De NNP cord-010119-t1x9gknd 3998 7 - - JJ cord-010119-t1x9gknd 3998 8 identified identify VBN cord-010119-t1x9gknd 3998 9 donor donor NN cord-010119-t1x9gknd 3998 10 plasma plasma NN cord-010119-t1x9gknd 3998 11 segments segment NNS cord-010119-t1x9gknd 3998 12 were be VBD cord-010119-t1x9gknd 3998 13 sequestered sequester VBN cord-010119-t1x9gknd 3998 14 and and CC cord-010119-t1x9gknd 3998 15 stored store VBN cord-010119-t1x9gknd 3998 16 frozen frozen JJ cord-010119-t1x9gknd 3998 17 until until IN cord-010119-t1x9gknd 3998 18 time time NN cord-010119-t1x9gknd 3998 19 of of IN cord-010119-t1x9gknd 3998 20 testing testing NN cord-010119-t1x9gknd 3998 21 . . . cord-010119-t1x9gknd 3999 1 Testing test VBG cord-010119-t1x9gknd 3999 2 for for IN cord-010119-t1x9gknd 3999 3 THC thc NN cord-010119-t1x9gknd 3999 4 and and CC cord-010119-t1x9gknd 3999 5 11-OH 11-oh CD cord-010119-t1x9gknd 3999 6 - - HYPH cord-010119-t1x9gknd 3999 7 THC thc NN cord-010119-t1x9gknd 3999 8 was be VBD cord-010119-t1x9gknd 3999 9 performed perform VBN cord-010119-t1x9gknd 3999 10 by by IN cord-010119-t1x9gknd 3999 11 liquid liquid JJ cord-010119-t1x9gknd 3999 12 chromatography chromatography NN cord-010119-t1x9gknd 3999 13 - - HYPH cord-010119-t1x9gknd 3999 14 tandem tandem NN cord-010119-t1x9gknd 3999 15 mass mass NN cord-010119-t1x9gknd 3999 16 spectrometry spectrometry NN cord-010119-t1x9gknd 3999 17 ( ( -LRB- cord-010119-t1x9gknd 3999 18 LC LC NNP cord-010119-t1x9gknd 3999 19 - - HYPH cord-010119-t1x9gknd 3999 20 MS MS NNP cord-010119-t1x9gknd 3999 21 / / SYM cord-010119-t1x9gknd 3999 22 MS MS NNP cord-010119-t1x9gknd 3999 23 ) ) -RRB- cord-010119-t1x9gknd 3999 24 based base VBN cord-010119-t1x9gknd 3999 25 on on IN cord-010119-t1x9gknd 3999 26 a a DT cord-010119-t1x9gknd 3999 27 method method NN cord-010119-t1x9gknd 3999 28 modified modify VBN cord-010119-t1x9gknd 3999 29 from from IN cord-010119-t1x9gknd 3999 30 Lacroix Lacroix NNP cord-010119-t1x9gknd 3999 31 and and CC cord-010119-t1x9gknd 3999 32 Saussereau Saussereau NNP cord-010119-t1x9gknd 3999 33 . . . cord-010119-t1x9gknd 4000 1 In in IN cord-010119-t1x9gknd 4000 2 summary summary NN cord-010119-t1x9gknd 4000 3 , , , cord-010119-t1x9gknd 4000 4 this this DT cord-010119-t1x9gknd 4000 5 method method NN cord-010119-t1x9gknd 4000 6 used use VBN cord-010119-t1x9gknd 4000 7 dabsyl dabsyl JJ cord-010119-t1x9gknd 4000 8 chloride chloride NN cord-010119-t1x9gknd 4000 9 derivatization derivatization NN cord-010119-t1x9gknd 4000 10 of of IN cord-010119-t1x9gknd 4000 11 THC thc NN cord-010119-t1x9gknd 4000 12 and and CC cord-010119-t1x9gknd 4000 13 11-OH 11-oh CD cord-010119-t1x9gknd 4000 14 - - HYPH cord-010119-t1x9gknd 4000 15 THC thc NN cord-010119-t1x9gknd 4000 16 to to TO cord-010119-t1x9gknd 4000 17 produce produce VB cord-010119-t1x9gknd 4000 18 samples sample NNS cord-010119-t1x9gknd 4000 19 for for IN cord-010119-t1x9gknd 4000 20 LC LC NNP cord-010119-t1x9gknd 4000 21 - - HYPH cord-010119-t1x9gknd 4000 22 MS MS NNP cord-010119-t1x9gknd 4000 23 / / SYM cord-010119-t1x9gknd 4000 24 MS MS NNP cord-010119-t1x9gknd 4000 25 analysis analysis NN cord-010119-t1x9gknd 4000 26 . . . cord-010119-t1x9gknd 4001 1 LC LC NNP cord-010119-t1x9gknd 4001 2 used use VBD cord-010119-t1x9gknd 4001 3 a a DT cord-010119-t1x9gknd 4001 4 C18 C18 NNP cord-010119-t1x9gknd 4001 5 column column NN cord-010119-t1x9gknd 4001 6 . . . cord-010119-t1x9gknd 4002 1 Post post JJ cord-010119-t1x9gknd 4002 2 - - JJ cord-010119-t1x9gknd 4002 3 column column JJ cord-010119-t1x9gknd 4002 4 detection detection NN cord-010119-t1x9gknd 4002 5 by by IN cord-010119-t1x9gknd 4002 6 MS MS NNP cord-010119-t1x9gknd 4002 7 / / SYM cord-010119-t1x9gknd 4002 8 MS MS NNP cord-010119-t1x9gknd 4002 9 used use VBD cord-010119-t1x9gknd 4002 10 positive positive JJ cord-010119-t1x9gknd 4002 11 ion ion NN cord-010119-t1x9gknd 4002 12 electrospray electrospray JJ cord-010119-t1x9gknd 4002 13 with with IN cord-010119-t1x9gknd 4002 14 Q1 Q1 NNP cord-010119-t1x9gknd 4002 15 : : : cord-010119-t1x9gknd 4002 16 Q3 Q3 NNP cord-010119-t1x9gknd 4002 17 ion ion NN cord-010119-t1x9gknd 4002 18 pairs pair NNS cord-010119-t1x9gknd 4002 19 of of IN cord-010119-t1x9gknd 4002 20 m m NNP cord-010119-t1x9gknd 4002 21 / / SYM cord-010119-t1x9gknd 4002 22 z z NNP cord-010119-t1x9gknd 4002 23 5 5 CD cord-010119-t1x9gknd 4002 24 605.3:225.3 605.3:225.3 CD cord-010119-t1x9gknd 4002 25 ( ( -LRB- cord-010119-t1x9gknd 4002 26 internal internal JJ cord-010119-t1x9gknd 4002 27 standard standard NN cord-010119-t1x9gknd 4002 28 ( ( -LRB- cord-010119-t1x9gknd 4002 29 IS be VBZ cord-010119-t1x9gknd 4002 30 ) ) -RRB- cord-010119-t1x9gknd 4002 31 , , , cord-010119-t1x9gknd 4002 32 d3-THC d3-thc ADD cord-010119-t1x9gknd 4002 33 ) ) -RRB- cord-010119-t1x9gknd 4002 34 , , . cord-010119-t1x9gknd 4003 1 m/ m/ NN cord-010119-t1x9gknd 4003 2 z z NNP cord-010119-t1x9gknd 4004 1 5 5 CD cord-010119-t1x9gknd 4004 2 602.2:225.2 602.2:225.2 CD cord-010119-t1x9gknd 4004 3 ( ( -LRB- cord-010119-t1x9gknd 4004 4 THC THC NNP cord-010119-t1x9gknd 4004 5 ) ) -RRB- cord-010119-t1x9gknd 4004 6 , , , cord-010119-t1x9gknd 4004 7 and and CC cord-010119-t1x9gknd 4004 8 m m NNP cord-010119-t1x9gknd 4004 9 / / SYM cord-010119-t1x9gknd 4004 10 z z NN cord-010119-t1x9gknd 4004 11 5 5 CD cord-010119-t1x9gknd 4004 12 618.3:256.1 618.3:256.1 CD cord-010119-t1x9gknd 4004 13 ( ( -LRB- cord-010119-t1x9gknd 4004 14 11-OH 11-oh CD cord-010119-t1x9gknd 4004 15 - - HYPH cord-010119-t1x9gknd 4004 16 THC thc NN cord-010119-t1x9gknd 4004 17 ) ) -RRB- cord-010119-t1x9gknd 4004 18 . . . cord-010119-t1x9gknd 4005 1 Quantitative quantitative JJ cord-010119-t1x9gknd 4005 2 results result NNS cord-010119-t1x9gknd 4005 3 for for IN cord-010119-t1x9gknd 4005 4 THC thc NN cord-010119-t1x9gknd 4005 5 and and CC cord-010119-t1x9gknd 4005 6 11-OH 11-oh CD cord-010119-t1x9gknd 4005 7 - - HYPH cord-010119-t1x9gknd 4005 8 THC thc NN cord-010119-t1x9gknd 4005 9 were be VBD cord-010119-t1x9gknd 4005 10 obtained obtain VBN cord-010119-t1x9gknd 4005 11 from from IN cord-010119-t1x9gknd 4005 12 a a DT cord-010119-t1x9gknd 4005 13 standard standard JJ cord-010119-t1x9gknd 4005 14 curve curve NN cord-010119-t1x9gknd 4005 15 ( ( -LRB- cord-010119-t1x9gknd 4005 16 ratio ratio NN cord-010119-t1x9gknd 4005 17 of of IN cord-010119-t1x9gknd 4005 18 analyte analyte JJ cord-010119-t1x9gknd 4005 19 integrals integral NNS cord-010119-t1x9gknd 4005 20 to to IN cord-010119-t1x9gknd 4005 21 integrals integral NNS cord-010119-t1x9gknd 4005 22 of of IN cord-010119-t1x9gknd 4005 23 internal internal JJ cord-010119-t1x9gknd 4005 24 standard standard NN cord-010119-t1x9gknd 4005 25 ) ) -RRB- cord-010119-t1x9gknd 4005 26 ranging range VBG cord-010119-t1x9gknd 4005 27 from from IN cord-010119-t1x9gknd 4005 28 0 0 CD cord-010119-t1x9gknd 4005 29 - - SYM cord-010119-t1x9gknd 4005 30 50 50 CD cord-010119-t1x9gknd 4005 31 ng/ ng/ NN cord-010119-t1x9gknd 4005 32 mL ml NN cord-010119-t1x9gknd 4005 33 for for IN cord-010119-t1x9gknd 4005 34 both both CC cord-010119-t1x9gknd 4005 35 THC thc NN cord-010119-t1x9gknd 4005 36 and and CC cord-010119-t1x9gknd 4005 37 11-OH 11-oh CD cord-010119-t1x9gknd 4005 38 - - HYPH cord-010119-t1x9gknd 4005 39 THC thc NN cord-010119-t1x9gknd 4005 40 . . . cord-010119-t1x9gknd 4006 1 Limits limit NNS cord-010119-t1x9gknd 4006 2 of of IN cord-010119-t1x9gknd 4006 3 quantitation quantitation NN cord-010119-t1x9gknd 4006 4 , , , cord-010119-t1x9gknd 4006 5 defined define VBN cord-010119-t1x9gknd 4006 6 as as IN cord-010119-t1x9gknd 4006 7 5 5 CD cord-010119-t1x9gknd 4006 8 standard standard JJ cord-010119-t1x9gknd 4006 9 deviations deviation NNS cord-010119-t1x9gknd 4006 10 above above IN cord-010119-t1x9gknd 4006 11 background background NN cord-010119-t1x9gknd 4006 12 , , , cord-010119-t1x9gknd 4006 13 were be VBD cord-010119-t1x9gknd 4006 14 0.7 0.7 CD cord-010119-t1x9gknd 4006 15 ng ng NN cord-010119-t1x9gknd 4006 16 / / SYM cord-010119-t1x9gknd 4006 17 mL ml NN cord-010119-t1x9gknd 4006 18 for for IN cord-010119-t1x9gknd 4006 19 THC thc NN cord-010119-t1x9gknd 4006 20 and and CC cord-010119-t1x9gknd 4006 21 7 7 CD cord-010119-t1x9gknd 4006 22 ng ng NN cord-010119-t1x9gknd 4006 23 / / SYM cord-010119-t1x9gknd 4006 24 mL ml NN cord-010119-t1x9gknd 4006 25 for for IN cord-010119-t1x9gknd 4006 26 11-OH 11-oh CD cord-010119-t1x9gknd 4006 27 - - HYPH cord-010119-t1x9gknd 4006 28 THC thc NN cord-010119-t1x9gknd 4006 29 . . . cord-010119-t1x9gknd 4007 1 Results/ Results/ . cord-010119-t1x9gknd 4008 1 Finding finding NN cord-010119-t1x9gknd 4008 2 : : : cord-010119-t1x9gknd 4008 3 A a DT cord-010119-t1x9gknd 4008 4 total total NN cord-010119-t1x9gknd 4008 5 of of IN cord-010119-t1x9gknd 4008 6 424 424 CD cord-010119-t1x9gknd 4008 7 donor donor NN cord-010119-t1x9gknd 4008 8 plasma plasma NN cord-010119-t1x9gknd 4008 9 samples sample NNS cord-010119-t1x9gknd 4008 10 were be VBD cord-010119-t1x9gknd 4008 11 tested test VBN cord-010119-t1x9gknd 4008 12 for for IN cord-010119-t1x9gknd 4008 13 THC thc NN cord-010119-t1x9gknd 4008 14 and and CC cord-010119-t1x9gknd 4008 15 11-OH 11-oh CD cord-010119-t1x9gknd 4008 16 - - HYPH cord-010119-t1x9gknd 4008 17 THC thc NN cord-010119-t1x9gknd 4008 18 . . . cord-010119-t1x9gknd 4009 1 No no DT cord-010119-t1x9gknd 4009 2 samples sample NNS cord-010119-t1x9gknd 4009 3 tested test VBD cord-010119-t1x9gknd 4009 4 positive positive JJ cord-010119-t1x9gknd 4009 5 for for IN cord-010119-t1x9gknd 4009 6 either either CC cord-010119-t1x9gknd 4009 7 THC thc NN cord-010119-t1x9gknd 4009 8 or or CC cord-010119-t1x9gknd 4009 9 11-OH 11-oh CD cord-010119-t1x9gknd 4009 10 - - HYPH cord-010119-t1x9gknd 4009 11 THC thc NN cord-010119-t1x9gknd 4009 12 . . . cord-010119-t1x9gknd 4010 1 Theoretical theoretical JJ cord-010119-t1x9gknd 4010 2 calculations calculation NNS cord-010119-t1x9gknd 4010 3 according accord VBG cord-010119-t1x9gknd 4010 4 to to IN cord-010119-t1x9gknd 4010 5 statistics statistic NNS cord-010119-t1x9gknd 4010 6 of of IN cord-010119-t1x9gknd 4010 7 a a DT cord-010119-t1x9gknd 4010 8 Poisson Poisson NNP cord-010119-t1x9gknd 4010 9 distribution distribution NN cord-010119-t1x9gknd 4010 10 indicated indicate VBD cord-010119-t1x9gknd 4010 11 that that IN cord-010119-t1x9gknd 4010 12 there there EX cord-010119-t1x9gknd 4010 13 would would MD cord-010119-t1x9gknd 4010 14 be be VB cord-010119-t1x9gknd 4010 15 a a DT cord-010119-t1x9gknd 4010 16 50 50 CD cord-010119-t1x9gknd 4010 17 % % NN cord-010119-t1x9gknd 4010 18 probability probability NN cord-010119-t1x9gknd 4010 19 of of IN cord-010119-t1x9gknd 4010 20 one one CD cord-010119-t1x9gknd 4010 21 or or CC cord-010119-t1x9gknd 4010 22 more more JJR cord-010119-t1x9gknd 4010 23 positives positive NNS cord-010119-t1x9gknd 4010 24 at at IN cord-010119-t1x9gknd 4010 25 a a DT cord-010119-t1x9gknd 4010 26 prevalence prevalence NN cord-010119-t1x9gknd 4010 27 of of IN cord-010119-t1x9gknd 4010 28 0.16 0.16 CD cord-010119-t1x9gknd 4010 29 % % NN cord-010119-t1x9gknd 4010 30 positive positive JJ cord-010119-t1x9gknd 4010 31 samples sample NNS cord-010119-t1x9gknd 4010 32 , , , cord-010119-t1x9gknd 4010 33 and and CC cord-010119-t1x9gknd 4010 34 a a DT cord-010119-t1x9gknd 4010 35 95 95 CD cord-010119-t1x9gknd 4010 36 % % NN cord-010119-t1x9gknd 4010 37 probability probability NN cord-010119-t1x9gknd 4010 38 of of IN cord-010119-t1x9gknd 4010 39 one one CD cord-010119-t1x9gknd 4010 40 or or CC cord-010119-t1x9gknd 4010 41 more more JJR cord-010119-t1x9gknd 4010 42 positives positive NNS cord-010119-t1x9gknd 4010 43 at at IN cord-010119-t1x9gknd 4010 44 a a DT cord-010119-t1x9gknd 4010 45 prevalence prevalence NN cord-010119-t1x9gknd 4010 46 of of IN cord-010119-t1x9gknd 4010 47 0.71 0.71 CD cord-010119-t1x9gknd 4010 48 % % NN cord-010119-t1x9gknd 4010 49 positive positive JJ cord-010119-t1x9gknd 4010 50 samples sample NNS cord-010119-t1x9gknd 4010 51 . . . cord-010119-t1x9gknd 4011 1 Results result NNS cord-010119-t1x9gknd 4011 2 thus thus RB cord-010119-t1x9gknd 4011 3 indicated indicate VBD cord-010119-t1x9gknd 4011 4 a a DT cord-010119-t1x9gknd 4011 5 boundary boundary NN cord-010119-t1x9gknd 4011 6 of of IN cord-010119-t1x9gknd 4011 7 prevalence prevalence NN cord-010119-t1x9gknd 4011 8 of of IN cord-010119-t1x9gknd 4011 9 the the DT cord-010119-t1x9gknd 4011 10 presence presence NN cord-010119-t1x9gknd 4011 11 of of IN cord-010119-t1x9gknd 4011 12 active active JJ cord-010119-t1x9gknd 4011 13 THC thc NN cord-010119-t1x9gknd 4011 14 - - HYPH cord-010119-t1x9gknd 4011 15 metabolites metabolite NNS cord-010119-t1x9gknd 4011 16 in in IN cord-010119-t1x9gknd 4011 17 plasma plasma NN cord-010119-t1x9gknd 4011 18 samples sample NNS cord-010119-t1x9gknd 4011 19 to to TO cord-010119-t1x9gknd 4011 20 be be VB cord-010119-t1x9gknd 4011 21 less less JJR cord-010119-t1x9gknd 4011 22 than than IN cord-010119-t1x9gknd 4011 23 1 1 CD cord-010119-t1x9gknd 4011 24 % % NN cord-010119-t1x9gknd 4011 25 among among IN cord-010119-t1x9gknd 4011 26 this this DT cord-010119-t1x9gknd 4011 27 donor donor NN cord-010119-t1x9gknd 4011 28 population population NN cord-010119-t1x9gknd 4011 29 . . . cord-010119-t1x9gknd 4012 1 Standard standard JJ cord-010119-t1x9gknd 4012 2 pharmacokinetics pharmacokinetic NNS cord-010119-t1x9gknd 4012 3 of of IN cord-010119-t1x9gknd 4012 4 cannabis cannabis NN cord-010119-t1x9gknd 4012 5 metabolism metabolism NN cord-010119-t1x9gknd 4012 6 in in IN cord-010119-t1x9gknd 4012 7 previous previous JJ cord-010119-t1x9gknd 4012 8 studies study NNS cord-010119-t1x9gknd 4012 9 indicate indicate VBP cord-010119-t1x9gknd 4012 10 a a DT cord-010119-t1x9gknd 4012 11 likely likely JJ cord-010119-t1x9gknd 4012 12 time time NN cord-010119-t1x9gknd 4012 13 window window NN cord-010119-t1x9gknd 4012 14 of of IN cord-010119-t1x9gknd 4012 15 less less JJR cord-010119-t1x9gknd 4012 16 than than IN cord-010119-t1x9gknd 4012 17 12 12 CD cord-010119-t1x9gknd 4012 18 hours hour NNS cord-010119-t1x9gknd 4012 19 for for IN cord-010119-t1x9gknd 4012 20 post post JJ cord-010119-t1x9gknd 4012 21 - - JJ cord-010119-t1x9gknd 4012 22 exposure exposure JJ cord-010119-t1x9gknd 4012 23 detection detection NN cord-010119-t1x9gknd 4012 24 of of IN cord-010119-t1x9gknd 4012 25 THC thc NN cord-010119-t1x9gknd 4012 26 and/or and/or CC cord-010119-t1x9gknd 4012 27 11-OH 11-oh CD cord-010119-t1x9gknd 4012 28 - - HYPH cord-010119-t1x9gknd 4012 29 THC thc NN cord-010119-t1x9gknd 4012 30 in in IN cord-010119-t1x9gknd 4012 31 plasma plasma NN cord-010119-t1x9gknd 4012 32 . . . cord-010119-t1x9gknd 4013 1 Conclusion conclusion NN cord-010119-t1x9gknd 4013 2 : : : cord-010119-t1x9gknd 4014 1 Testing testing NN cord-010119-t1x9gknd 4014 2 of of IN cord-010119-t1x9gknd 4014 3 424 424 CD cord-010119-t1x9gknd 4014 4 donor donor NN cord-010119-t1x9gknd 4014 5 plasma plasma NN cord-010119-t1x9gknd 4014 6 samples sample NNS cord-010119-t1x9gknd 4014 7 for for IN cord-010119-t1x9gknd 4014 8 active active JJ cord-010119-t1x9gknd 4014 9 metabolites metabolite NNS cord-010119-t1x9gknd 4014 10 of of IN cord-010119-t1x9gknd 4014 11 cannabis cannabis NN cord-010119-t1x9gknd 4014 12 at at IN cord-010119-t1x9gknd 4014 13 one one CD cord-010119-t1x9gknd 4014 14 urban urban JJ cord-010119-t1x9gknd 4014 15 , , , cord-010119-t1x9gknd 4014 16 hospital hospital NN cord-010119-t1x9gknd 4014 17 - - HYPH cord-010119-t1x9gknd 4014 18 based base VBN cord-010119-t1x9gknd 4014 19 blood blood NN cord-010119-t1x9gknd 4014 20 donor donor NN cord-010119-t1x9gknd 4014 21 center center NN cord-010119-t1x9gknd 4014 22 produced produce VBD cord-010119-t1x9gknd 4014 23 no no DT cord-010119-t1x9gknd 4014 24 testpositives testpositive NNS cord-010119-t1x9gknd 4014 25 . . . cord-010119-t1x9gknd 4015 1 Statistically statistically RB cord-010119-t1x9gknd 4015 2 , , , cord-010119-t1x9gknd 4015 3 results result NNS cord-010119-t1x9gknd 4015 4 indicated indicate VBD cord-010119-t1x9gknd 4015 5 that that IN cord-010119-t1x9gknd 4015 6 prevalence prevalence NN cord-010119-t1x9gknd 4015 7 of of IN cord-010119-t1x9gknd 4015 8 positivity positivity NN cord-010119-t1x9gknd 4015 9 , , , cord-010119-t1x9gknd 4015 10 if if IN cord-010119-t1x9gknd 4015 11 greater great JJR cord-010119-t1x9gknd 4015 12 than than IN cord-010119-t1x9gknd 4015 13 zero zero CD cord-010119-t1x9gknd 4015 14 , , , cord-010119-t1x9gknd 4015 15 is be VBZ cord-010119-t1x9gknd 4015 16 at at RB cord-010119-t1x9gknd 4015 17 most most RBS cord-010119-t1x9gknd 4015 18 less less JJR cord-010119-t1x9gknd 4015 19 than than IN cord-010119-t1x9gknd 4015 20 1 1 CD cord-010119-t1x9gknd 4015 21 % % NN cord-010119-t1x9gknd 4015 22 . . . cord-010119-t1x9gknd 4016 1 Probability probability NN cord-010119-t1x9gknd 4016 2 of of IN cord-010119-t1x9gknd 4016 3 occurrence occurrence NN cord-010119-t1x9gknd 4016 4 of of IN cord-010119-t1x9gknd 4016 5 cannabis cannabis NN cord-010119-t1x9gknd 4016 6 metabolites metabolite NNS cord-010119-t1x9gknd 4016 7 in in IN cord-010119-t1x9gknd 4016 8 blood blood NN cord-010119-t1x9gknd 4016 9 donor donor NN cord-010119-t1x9gknd 4016 10 samples sample NNS cord-010119-t1x9gknd 4016 11 is be VBZ cord-010119-t1x9gknd 4016 12 likely likely JJ cord-010119-t1x9gknd 4016 13 to to TO cord-010119-t1x9gknd 4016 14 be be VB cord-010119-t1x9gknd 4016 15 highly highly RB cord-010119-t1x9gknd 4016 16 variable variable JJ cord-010119-t1x9gknd 4016 17 across across IN cord-010119-t1x9gknd 4016 18 donor donor NN cord-010119-t1x9gknd 4016 19 centers center NNS cord-010119-t1x9gknd 4016 20 and and CC cord-010119-t1x9gknd 4016 21 is be VBZ cord-010119-t1x9gknd 4016 22 largely largely RB cord-010119-t1x9gknd 4016 23 dependent dependent JJ cord-010119-t1x9gknd 4016 24 on on IN cord-010119-t1x9gknd 4016 25 blood blood NN cord-010119-t1x9gknd 4016 26 donor donor NN cord-010119-t1x9gknd 4016 27 demographics demographic NNS cord-010119-t1x9gknd 4016 28 . . . cord-010119-t1x9gknd 4017 1 Elisabeth Elisabeth NNP cord-010119-t1x9gknd 4017 2 Maurer Maurer NNP cord-010119-t1x9gknd 4017 3 - - HYPH cord-010119-t1x9gknd 4017 4 Spurej Spurej NNP cord-010119-t1x9gknd 4017 5 * * NFP cord-010119-t1x9gknd 4017 6 1 1 CD cord-010119-t1x9gknd 4017 7 , , , cord-010119-t1x9gknd 4017 8 Ruqayyah Ruqayyah NNP cord-010119-t1x9gknd 4017 9 Almizraq Almizraq NNP cord-010119-t1x9gknd 4017 10 2 2 CD cord-010119-t1x9gknd 4017 11 , , , cord-010119-t1x9gknd 4017 12 Daniel Daniel NNP cord-010119-t1x9gknd 4017 13 Millar Millar NNP cord-010119-t1x9gknd 4017 14 3 3 CD cord-010119-t1x9gknd 4017 15 and and CC cord-010119-t1x9gknd 4017 16 Jason Jason NNP cord-010119-t1x9gknd 4017 17 P. P. NNP cord-010119-t1x9gknd 4017 18 Acker Acker NNP cord-010119-t1x9gknd 4017 19 4 4 CD cord-010119-t1x9gknd 4017 20 . . . cord-010119-t1x9gknd 4018 1 1 1 CD cord-010119-t1x9gknd 4018 2 University University NNP cord-010119-t1x9gknd 4018 3 of of IN cord-010119-t1x9gknd 4018 4 British British NNP cord-010119-t1x9gknd 4018 5 Columbia Columbia NNP cord-010119-t1x9gknd 4018 6 , , , cord-010119-t1x9gknd 4018 7 2 2 CD cord-010119-t1x9gknd 4018 8 University University NNP cord-010119-t1x9gknd 4018 9 of of IN cord-010119-t1x9gknd 4018 10 Alberta Alberta NNP cord-010119-t1x9gknd 4018 11 , , , cord-010119-t1x9gknd 4018 12 3 3 CD cord-010119-t1x9gknd 4018 13 LightIntegra LightIntegra NNP cord-010119-t1x9gknd 4018 14 Technology Technology NNP cord-010119-t1x9gknd 4018 15 Inc. Inc. NNP cord-010119-t1x9gknd 4018 16 , , , cord-010119-t1x9gknd 4018 17 4 4 CD cord-010119-t1x9gknd 4018 18 Canadian Canadian NNP cord-010119-t1x9gknd 4018 19 Blood Blood NNP cord-010119-t1x9gknd 4018 20 Services Services NNPS cord-010119-t1x9gknd 4018 21 Background Background NNP cord-010119-t1x9gknd 4018 22 / / SYM cord-010119-t1x9gknd 4018 23 Case Case NNP cord-010119-t1x9gknd 4018 24 Studies Studies NNPS cord-010119-t1x9gknd 4018 25 : : : cord-010119-t1x9gknd 4019 1 The the DT cord-010119-t1x9gknd 4019 2 controversy controversy NN cord-010119-t1x9gknd 4019 3 around around IN cord-010119-t1x9gknd 4019 4 the the DT cord-010119-t1x9gknd 4019 5 quality quality NN cord-010119-t1x9gknd 4019 6 and and CC cord-010119-t1x9gknd 4019 7 clinical clinical JJ cord-010119-t1x9gknd 4019 8 impact impact NN cord-010119-t1x9gknd 4019 9 of of IN cord-010119-t1x9gknd 4019 10 aged aged JJ cord-010119-t1x9gknd 4019 11 red red JJ cord-010119-t1x9gknd 4019 12 blood blood NN cord-010119-t1x9gknd 4019 13 cell cell NN cord-010119-t1x9gknd 4019 14 concentrates concentrate VBZ cord-010119-t1x9gknd 4019 15 ( ( -LRB- cord-010119-t1x9gknd 4019 16 RCC RCC NNP cord-010119-t1x9gknd 4019 17 ) ) -RRB- cord-010119-t1x9gknd 4019 18 is be VBZ cord-010119-t1x9gknd 4019 19 ongoing ongoing JJ cord-010119-t1x9gknd 4019 20 . . . cord-010119-t1x9gknd 4020 1 Current current JJ cord-010119-t1x9gknd 4020 2 studies study NNS cord-010119-t1x9gknd 4020 3 are be VBP cord-010119-t1x9gknd 4020 4 limited limit VBN cord-010119-t1x9gknd 4020 5 by by IN cord-010119-t1x9gknd 4020 6 the the DT cord-010119-t1x9gknd 4020 7 lack lack NN cord-010119-t1x9gknd 4020 8 of of IN cord-010119-t1x9gknd 4020 9 quality quality NN cord-010119-t1x9gknd 4020 10 measures measure NNS cord-010119-t1x9gknd 4020 11 suitable suitable JJ cord-010119-t1x9gknd 4020 12 for for IN cord-010119-t1x9gknd 4020 13 routine routine JJ cord-010119-t1x9gknd 4020 14 screening screening NN cord-010119-t1x9gknd 4020 15 of of IN cord-010119-t1x9gknd 4020 16 RCC RCC NNP cord-010119-t1x9gknd 4020 17 . . . cord-010119-t1x9gknd 4021 1 Based base VBN cord-010119-t1x9gknd 4021 2 on on IN cord-010119-t1x9gknd 4021 3 evidence evidence NN cord-010119-t1x9gknd 4021 4 that that IN cord-010119-t1x9gknd 4021 5 fragments fragment NNS cord-010119-t1x9gknd 4021 6 called call VBD cord-010119-t1x9gknd 4021 7 microparticles microparticle NNS cord-010119-t1x9gknd 4021 8 ( ( -LRB- cord-010119-t1x9gknd 4021 9 MP MP NNP cord-010119-t1x9gknd 4021 10 ) ) -RRB- cord-010119-t1x9gknd 4021 11 or or CC cord-010119-t1x9gknd 4021 12 extracellular extracellular JJ cord-010119-t1x9gknd 4021 13 vesicles vesicle NNS cord-010119-t1x9gknd 4021 14 are be VBP cord-010119-t1x9gknd 4021 15 markers marker NNS cord-010119-t1x9gknd 4021 16 of of IN cord-010119-t1x9gknd 4021 17 cellular cellular JJ cord-010119-t1x9gknd 4021 18 activation activation NN cord-010119-t1x9gknd 4021 19 or or CC cord-010119-t1x9gknd 4021 20 degradation degradation NN cord-010119-t1x9gknd 4021 21 , , , cord-010119-t1x9gknd 4021 22 this this DT cord-010119-t1x9gknd 4021 23 study study NN cord-010119-t1x9gknd 4021 24 investigated investigate VBD cord-010119-t1x9gknd 4021 25 the the DT cord-010119-t1x9gknd 4021 26 utility utility NN cord-010119-t1x9gknd 4021 27 of of IN cord-010119-t1x9gknd 4021 28 MP MP NNP cord-010119-t1x9gknd 4021 29 screening screening NN cord-010119-t1x9gknd 4021 30 to to TO cord-010119-t1x9gknd 4021 31 characterize characterize VB cord-010119-t1x9gknd 4021 32 the the DT cord-010119-t1x9gknd 4021 33 effect effect NN cord-010119-t1x9gknd 4021 34 of of IN cord-010119-t1x9gknd 4021 35 RCC RCC NNP cord-010119-t1x9gknd 4021 36 production production NN cord-010119-t1x9gknd 4021 37 methods method NNS cord-010119-t1x9gknd 4021 38 and and CC cord-010119-t1x9gknd 4021 39 storage storage NN cord-010119-t1x9gknd 4021 40 . . . cord-010119-t1x9gknd 4022 1 Study Study NNP cord-010119-t1x9gknd 4022 2 Design Design NNP cord-010119-t1x9gknd 4022 3 / / SYM cord-010119-t1x9gknd 4022 4 Method method NN cord-010119-t1x9gknd 4022 5 : : : cord-010119-t1x9gknd 4023 1 Red red JJ cord-010119-t1x9gknd 4023 2 blood blood NN cord-010119-t1x9gknd 4023 3 cell cell NN cord-010119-t1x9gknd 4023 4 concentrates concentrate NNS cord-010119-t1x9gknd 4023 5 were be VBD cord-010119-t1x9gknd 4023 6 prepared prepare VBN cord-010119-t1x9gknd 4023 7 by by IN cord-010119-t1x9gknd 4023 8 whole whole JJ cord-010119-t1x9gknd 4023 9 blood blood NN cord-010119-t1x9gknd 4023 10 filtration filtration NN cord-010119-t1x9gknd 4023 11 ( ( -LRB- cord-010119-t1x9gknd 4023 12 WBF WBF NNP cord-010119-t1x9gknd 4023 13 ; ; : cord-010119-t1x9gknd 4023 14 Top Top NNP cord-010119-t1x9gknd 4023 15 / / SYM cord-010119-t1x9gknd 4023 16 Top top NN cord-010119-t1x9gknd 4023 17 ) ) -RRB- cord-010119-t1x9gknd 4023 18 or or CC cord-010119-t1x9gknd 4023 19 red red JJ cord-010119-t1x9gknd 4023 20 cell cell NN cord-010119-t1x9gknd 4023 21 filtration filtration NN cord-010119-t1x9gknd 4023 22 ( ( -LRB- cord-010119-t1x9gknd 4023 23 RCF RCF NNP cord-010119-t1x9gknd 4023 24 ; ; : cord-010119-t1x9gknd 4023 25 Top Top NNP cord-010119-t1x9gknd 4023 26 / / SYM cord-010119-t1x9gknd 4023 27 Bottom bottom NN cord-010119-t1x9gknd 4023 28 ) ) -RRB- cord-010119-t1x9gknd 4023 29 methods method NNS cord-010119-t1x9gknd 4023 30 , , , cord-010119-t1x9gknd 4023 31 centrifuged centrifuge VBN cord-010119-t1x9gknd 4023 32 to to TO cord-010119-t1x9gknd 4023 33 prepare prepare VB cord-010119-t1x9gknd 4023 34 a a DT cord-010119-t1x9gknd 4023 35 supernatant supernatant NN cord-010119-t1x9gknd 4023 36 and and CC cord-010119-t1x9gknd 4023 37 tested test VBN cord-010119-t1x9gknd 4023 38 for for IN cord-010119-t1x9gknd 4023 39 MP MP NNP cord-010119-t1x9gknd 4023 40 content content NN cord-010119-t1x9gknd 4023 41 ( ( -LRB- cord-010119-t1x9gknd 4023 42 as as IN cord-010119-t1x9gknd 4023 43 measured measure VBN cord-010119-t1x9gknd 4023 44 with with IN cord-010119-t1x9gknd 4023 45 dynamic dynamic JJ cord-010119-t1x9gknd 4023 46 light light JJ cord-010119-t1x9gknd 4023 47 scattering scattering NN cord-010119-t1x9gknd 4023 48 or or CC cord-010119-t1x9gknd 4023 49 a a DT cord-010119-t1x9gknd 4023 50 tunable tunable JJ cord-010119-t1x9gknd 4023 51 resistive resistive JJ cord-010119-t1x9gknd 4023 52 pulse pulse NN cord-010119-t1x9gknd 4023 53 sensing sensing NN cord-010119-t1x9gknd 4023 54 technique technique NN cord-010119-t1x9gknd 4023 55 ) ) -RRB- cord-010119-t1x9gknd 4023 56 , , , cord-010119-t1x9gknd 4023 57 hemolysis hemolysis NN cord-010119-t1x9gknd 4023 58 , , , cord-010119-t1x9gknd 4023 59 ATP ATP NNP cord-010119-t1x9gknd 4023 60 and and CC cord-010119-t1x9gknd 4023 61 red red JJ cord-010119-t1x9gknd 4023 62 cell cell NN cord-010119-t1x9gknd 4023 63 deformability deformability NN cord-010119-t1x9gknd 4023 64 on on IN cord-010119-t1x9gknd 4023 65 days day NNS cord-010119-t1x9gknd 4023 66 7 7 CD cord-010119-t1x9gknd 4023 67 , , , cord-010119-t1x9gknd 4023 68 21 21 CD cord-010119-t1x9gknd 4023 69 , , , cord-010119-t1x9gknd 4023 70 and and CC cord-010119-t1x9gknd 4023 71 42 42 CD cord-010119-t1x9gknd 4023 72 of of IN cord-010119-t1x9gknd 4023 73 storage storage NN cord-010119-t1x9gknd 4023 74 . . . cord-010119-t1x9gknd 4024 1 One one CD cord-010119-t1x9gknd 4024 2 RCF RCF NNP cord-010119-t1x9gknd 4024 3 RCC RCC NNP cord-010119-t1x9gknd 4024 4 was be VBD cord-010119-t1x9gknd 4024 5 tested test VBN cord-010119-t1x9gknd 4024 6 on on IN cord-010119-t1x9gknd 4024 7 days day NNS cord-010119-t1x9gknd 4024 8 1 1 CD cord-010119-t1x9gknd 4024 9 , , , cord-010119-t1x9gknd 4024 10 5 5 CD cord-010119-t1x9gknd 4024 11 , , , cord-010119-t1x9gknd 4024 12 14 14 CD cord-010119-t1x9gknd 4024 13 , , , cord-010119-t1x9gknd 4024 14 21 21 CD cord-010119-t1x9gknd 4024 15 , , , cord-010119-t1x9gknd 4024 16 and and CC cord-010119-t1x9gknd 4024 17 43 43 CD cord-010119-t1x9gknd 4024 18 and and CC cord-010119-t1x9gknd 4024 19 six six CD cord-010119-t1x9gknd 4024 20 10 10 CD cord-010119-t1x9gknd 4024 21 mL ml NN cord-010119-t1x9gknd 4024 22 aliquots aliquot NNS cord-010119-t1x9gknd 4024 23 were be VBD cord-010119-t1x9gknd 4024 24 stored store VBN cord-010119-t1x9gknd 4024 25 in in IN cord-010119-t1x9gknd 4024 26 parallel parallel NN cord-010119-t1x9gknd 4024 27 and and CC cord-010119-t1x9gknd 4024 28 tested test VBN cord-010119-t1x9gknd 4024 29 on on IN cord-010119-t1x9gknd 4024 30 days day NNS cord-010119-t1x9gknd 4024 31 14 14 CD cord-010119-t1x9gknd 4024 32 , , , cord-010119-t1x9gknd 4024 33 21 21 CD cord-010119-t1x9gknd 4024 34 , , , cord-010119-t1x9gknd 4024 35 and and CC cord-010119-t1x9gknd 4024 36 43 43 CD cord-010119-t1x9gknd 4024 37 . . . cord-010119-t1x9gknd 4025 1 All all DT cord-010119-t1x9gknd 4025 2 samples sample NNS cord-010119-t1x9gknd 4025 3 were be VBD cord-010119-t1x9gknd 4025 4 tested test VBN cord-010119-t1x9gknd 4025 5 for for IN cord-010119-t1x9gknd 4025 6 MP MP NNP cord-010119-t1x9gknd 4025 7 Content Content NNP cord-010119-t1x9gknd 4025 8 and and CC cord-010119-t1x9gknd 4025 9 compared compare VBN cord-010119-t1x9gknd 4025 10 to to IN cord-010119-t1x9gknd 4025 11 the the DT cord-010119-t1x9gknd 4025 12 other other JJ cord-010119-t1x9gknd 4025 13 quality quality NN cord-010119-t1x9gknd 4025 14 indicators indicator NNS cord-010119-t1x9gknd 4025 15 . . . cord-010119-t1x9gknd 4026 1 Results/ Results/ . cord-010119-t1x9gknd 4027 1 Finding finding NN cord-010119-t1x9gknd 4027 2 : : : cord-010119-t1x9gknd 4028 1 MP MP NNP cord-010119-t1x9gknd 4028 2 Content Content NNP cord-010119-t1x9gknd 4028 3 showed show VBD cord-010119-t1x9gknd 4028 4 a a DT cord-010119-t1x9gknd 4028 5 linear linear JJ cord-010119-t1x9gknd 4028 6 increase increase NN cord-010119-t1x9gknd 4028 7 with with IN cord-010119-t1x9gknd 4028 8 storage storage NN cord-010119-t1x9gknd 4028 9 time time NN cord-010119-t1x9gknd 4028 10 with with IN cord-010119-t1x9gknd 4028 11 statistically statistically RB cord-010119-t1x9gknd 4028 12 significant significant JJ cord-010119-t1x9gknd 4028 13 differences difference NNS cord-010119-t1x9gknd 4028 14 between between IN cord-010119-t1x9gknd 4028 15 days day NNS cord-010119-t1x9gknd 4028 16 14 14 CD cord-010119-t1x9gknd 4028 17 , , , cord-010119-t1x9gknd 4028 18 21 21 CD cord-010119-t1x9gknd 4028 19 and and CC cord-010119-t1x9gknd 4028 20 43 43 CD cord-010119-t1x9gknd 4028 21 ( ( -LRB- cord-010119-t1x9gknd 4028 22 p<0.001 p<0.001 CD cord-010119-t1x9gknd 4028 23 ) ) -RRB- cord-010119-t1x9gknd 4028 24 and and CC cord-010119-t1x9gknd 4028 25 correlated correlate VBN cord-010119-t1x9gknd 4028 26 with with IN cord-010119-t1x9gknd 4028 27 supernatant supernatant JJ cord-010119-t1x9gknd 4028 28 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4028 29 , , , cord-010119-t1x9gknd 4028 30 and and CC cord-010119-t1x9gknd 4028 31 inversely inversely RB cord-010119-t1x9gknd 4028 32 with with IN cord-010119-t1x9gknd 4028 33 ATP ATP NNP cord-010119-t1x9gknd 4028 34 or or CC cord-010119-t1x9gknd 4028 35 RBC RBC NNP cord-010119-t1x9gknd 4028 36 elasticity elasticity NN cord-010119-t1x9gknd 4028 37 . . . cord-010119-t1x9gknd 4029 1 Both both DT cord-010119-t1x9gknd 4029 2 MP MP NNP cord-010119-t1x9gknd 4029 3 testing testing NN cord-010119-t1x9gknd 4029 4 methods method NNS cord-010119-t1x9gknd 4029 5 agreed agree VBD cord-010119-t1x9gknd 4029 6 with with IN cord-010119-t1x9gknd 4029 7 respect respect NN cord-010119-t1x9gknd 4029 8 to to IN cord-010119-t1x9gknd 4029 9 total total JJ cord-010119-t1x9gknd 4029 10 MP MP NNP cord-010119-t1x9gknd 4029 11 Content Content NNP cord-010119-t1x9gknd 4029 12 . . . cord-010119-t1x9gknd 4030 1 Starting start VBG cord-010119-t1x9gknd 4030 2 levels level NNS cord-010119-t1x9gknd 4030 3 of of IN cord-010119-t1x9gknd 4030 4 the the DT cord-010119-t1x9gknd 4030 5 quality quality NN cord-010119-t1x9gknd 4030 6 indicators indicator NNS cord-010119-t1x9gknd 4030 7 varied vary VBN cord-010119-t1x9gknd 4030 8 between between IN cord-010119-t1x9gknd 4030 9 donations donation NNS cord-010119-t1x9gknd 4030 10 , , , cord-010119-t1x9gknd 4030 11 preparation preparation NN cord-010119-t1x9gknd 4030 12 methods method NNS cord-010119-t1x9gknd 4030 13 ( ( -LRB- cord-010119-t1x9gknd 4030 14 WBF WBF NNP cord-010119-t1x9gknd 4030 15 RCC RCC NNP cord-010119-t1x9gknd 4030 16 contained contain VBD cord-010119-t1x9gknd 4030 17 much much RB cord-010119-t1x9gknd 4030 18 higher high JJR cord-010119-t1x9gknd 4030 19 levels level NNS cord-010119-t1x9gknd 4030 20 of of IN cord-010119-t1x9gknd 4030 21 MP MP NNP cord-010119-t1x9gknd 4030 22 ) ) -RRB- cord-010119-t1x9gknd 4030 23 , , , cord-010119-t1x9gknd 4030 24 and and CC cord-010119-t1x9gknd 4030 25 storage storage NN cord-010119-t1x9gknd 4030 26 time time NN cord-010119-t1x9gknd 4030 27 . . . cord-010119-t1x9gknd 4031 1 MP MP NNP cord-010119-t1x9gknd 4031 2 Content Content NNP cord-010119-t1x9gknd 4031 3 in in IN cord-010119-t1x9gknd 4031 4 the the DT cord-010119-t1x9gknd 4031 5 6 6 CD cord-010119-t1x9gknd 4031 6 aliquots aliquot NNS cord-010119-t1x9gknd 4031 7 were be VBD cord-010119-t1x9gknd 4031 8 consistent consistent JJ cord-010119-t1x9gknd 4031 9 at at IN cord-010119-t1x9gknd 4031 10 each each DT cord-010119-t1x9gknd 4031 11 time time NN cord-010119-t1x9gknd 4031 12 point point NN cord-010119-t1x9gknd 4031 13 but but CC cord-010119-t1x9gknd 4031 14 statistically statistically RB cord-010119-t1x9gknd 4031 15 higher high JJR cord-010119-t1x9gknd 4031 16 than than IN cord-010119-t1x9gknd 4031 17 in in IN cord-010119-t1x9gknd 4031 18 the the DT cord-010119-t1x9gknd 4031 19 original original JJ cord-010119-t1x9gknd 4031 20 RCC RCC NNP cord-010119-t1x9gknd 4031 21 on on IN cord-010119-t1x9gknd 4031 22 and and CC cord-010119-t1x9gknd 4031 23 after after IN cord-010119-t1x9gknd 4031 24 day day NN cord-010119-t1x9gknd 4031 25 21 21 CD cord-010119-t1x9gknd 4031 26 of of IN cord-010119-t1x9gknd 4031 27 storage storage NN cord-010119-t1x9gknd 4031 28 . . . cord-010119-t1x9gknd 4032 1 Conclusion conclusion NN cord-010119-t1x9gknd 4032 2 : : : cord-010119-t1x9gknd 4033 1 MP MP NNP cord-010119-t1x9gknd 4033 2 Content Content NNP cord-010119-t1x9gknd 4033 3 correlates correlate VBZ cord-010119-t1x9gknd 4033 4 with with IN cord-010119-t1x9gknd 4033 5 measures measure NNS cord-010119-t1x9gknd 4033 6 of of IN cord-010119-t1x9gknd 4033 7 hemolysis hemolysis NN cord-010119-t1x9gknd 4033 8 and and CC cord-010119-t1x9gknd 4033 9 other other JJ cord-010119-t1x9gknd 4033 10 RBC RBC NNP cord-010119-t1x9gknd 4033 11 quality quality NN cord-010119-t1x9gknd 4033 12 indicators indicator NNS cord-010119-t1x9gknd 4033 13 and and CC cord-010119-t1x9gknd 4033 14 could could MD cord-010119-t1x9gknd 4033 15 be be VB cord-010119-t1x9gknd 4033 16 implemented implement VBN cord-010119-t1x9gknd 4033 17 as as IN cord-010119-t1x9gknd 4033 18 a a DT cord-010119-t1x9gknd 4033 19 routine routine JJ cord-010119-t1x9gknd 4033 20 screening screening NN cord-010119-t1x9gknd 4033 21 tool tool NN cord-010119-t1x9gknd 4033 22 . . . cord-010119-t1x9gknd 4034 1 Differences difference NNS cord-010119-t1x9gknd 4034 2 in in IN cord-010119-t1x9gknd 4034 3 MP MP NNP cord-010119-t1x9gknd 4034 4 content content NN cord-010119-t1x9gknd 4034 5 between between IN cord-010119-t1x9gknd 4034 6 donors donor NNS cord-010119-t1x9gknd 4034 7 , , , cord-010119-t1x9gknd 4034 8 processes process NNS cord-010119-t1x9gknd 4034 9 and and CC cord-010119-t1x9gknd 4034 10 age age NN cord-010119-t1x9gknd 4034 11 could could MD cord-010119-t1x9gknd 4034 12 be be VB cord-010119-t1x9gknd 4034 13 monitored monitor VBN cord-010119-t1x9gknd 4034 14 and and CC cord-010119-t1x9gknd 4034 15 used use VBN cord-010119-t1x9gknd 4034 16 to to TO cord-010119-t1x9gknd 4034 17 inform inform VB cord-010119-t1x9gknd 4034 18 component component NN cord-010119-t1x9gknd 4034 19 production production NN cord-010119-t1x9gknd 4034 20 decisions decision NNS cord-010119-t1x9gknd 4034 21 . . . cord-010119-t1x9gknd 4035 1 Measuring measure VBG cord-010119-t1x9gknd 4035 2 MP MP NNP cord-010119-t1x9gknd 4035 3 Content Content NNP cord-010119-t1x9gknd 4035 4 would would MD cord-010119-t1x9gknd 4035 5 allow allow VB cord-010119-t1x9gknd 4035 6 100 100 CD cord-010119-t1x9gknd 4035 7 % % NN cord-010119-t1x9gknd 4035 8 screening screening NN cord-010119-t1x9gknd 4035 9 of of IN cord-010119-t1x9gknd 4035 10 RCC RCC NNP cord-010119-t1x9gknd 4035 11 products product NNS cord-010119-t1x9gknd 4035 12 in in IN cord-010119-t1x9gknd 4035 13 studies study NNS cord-010119-t1x9gknd 4035 14 and and CC cord-010119-t1x9gknd 4035 15 pragmatic pragmatic JJ cord-010119-t1x9gknd 4035 16 QC QC NNP cord-010119-t1x9gknd 4035 17 initiatives initiative NNS cord-010119-t1x9gknd 4035 18 which which WDT cord-010119-t1x9gknd 4035 19 are be VBP cord-010119-t1x9gknd 4035 20 needed need VBN cord-010119-t1x9gknd 4035 21 to to TO cord-010119-t1x9gknd 4035 22 settle settle VB cord-010119-t1x9gknd 4035 23 the the DT cord-010119-t1x9gknd 4035 24 controversy controversy NN cord-010119-t1x9gknd 4035 25 about about IN cord-010119-t1x9gknd 4035 26 the the DT cord-010119-t1x9gknd 4035 27 clinical clinical JJ cord-010119-t1x9gknd 4035 28 effect effect NN cord-010119-t1x9gknd 4035 29 of of IN cord-010119-t1x9gknd 4035 30 RCC RCC NNP cord-010119-t1x9gknd 4035 31 age age NN cord-010119-t1x9gknd 4035 32 . . . cord-010119-t1x9gknd 4036 1 Single single JJ cord-010119-t1x9gknd 4036 2 Donor Donor NNP cord-010119-t1x9gknd 4036 3 Spray Spray NNP cord-010119-t1x9gknd 4036 4 - - HYPH cord-010119-t1x9gknd 4036 5 Dried dry VBN cord-010119-t1x9gknd 4036 6 Plasma plasma NN cord-010119-t1x9gknd 4036 7 : : : cord-010119-t1x9gknd 4037 1 The the DT cord-010119-t1x9gknd 4037 2 Future Future NNP cord-010119-t1x9gknd 4037 3 of of IN cord-010119-t1x9gknd 4037 4 Plasma Plasma NNP cord-010119-t1x9gknd 4037 5 Therapy Therapy NNP cord-010119-t1x9gknd 4037 6 ? ? . cord-010119-t1x9gknd 4038 1 Qiyong Qiyong NNP cord-010119-t1x9gknd 4038 2 Peter Peter NNP cord-010119-t1x9gknd 4038 3 Liu Liu NNP cord-010119-t1x9gknd 4039 1 * * NFP cord-010119-t1x9gknd 4039 2 , , , cord-010119-t1x9gknd 4039 3 Jihae Jihae NNP cord-010119-t1x9gknd 4039 4 Sohn Sohn NNP cord-010119-t1x9gknd 4039 5 , , , cord-010119-t1x9gknd 4039 6 Ryan Ryan NNP cord-010119-t1x9gknd 4039 7 C. C. NNP cord-010119-t1x9gknd 4039 8 Carney Carney NNP cord-010119-t1x9gknd 4039 9 , , , cord-010119-t1x9gknd 4039 10 Sruthi Sruthi NNP cord-010119-t1x9gknd 4039 11 Sundaram Sundaram NNP cord-010119-t1x9gknd 4039 12 and and CC cord-010119-t1x9gknd 4039 13 Mark Mark NNP cord-010119-t1x9gknd 4039 14 A A NNP cord-010119-t1x9gknd 4039 15 Popovsky Popovsky NNP cord-010119-t1x9gknd 4039 16 . . . cord-010119-t1x9gknd 4040 1 Velico Velico NNP cord-010119-t1x9gknd 4040 2 Medical Medical NNP cord-010119-t1x9gknd 4040 3 Inc Inc NNP cord-010119-t1x9gknd 4040 4 Background Background NNP cord-010119-t1x9gknd 4040 5 / / SYM cord-010119-t1x9gknd 4040 6 Case Case NNP cord-010119-t1x9gknd 4040 7 Studies Studies NNPS cord-010119-t1x9gknd 4040 8 : : : cord-010119-t1x9gknd 4040 9 Frozen frozen JJ cord-010119-t1x9gknd 4040 10 plasma plasma NN cord-010119-t1x9gknd 4040 11 is be VBZ cord-010119-t1x9gknd 4040 12 integral integral JJ cord-010119-t1x9gknd 4040 13 to to IN cord-010119-t1x9gknd 4040 14 hemostasis hemostasis NN cord-010119-t1x9gknd 4040 15 management management NN cord-010119-t1x9gknd 4040 16 in in IN cord-010119-t1x9gknd 4040 17 many many JJ cord-010119-t1x9gknd 4040 18 situations situation NNS cord-010119-t1x9gknd 4040 19 but but CC cord-010119-t1x9gknd 4040 20 logistically logistically RB cord-010119-t1x9gknd 4040 21 cumbersome cumbersome JJ cord-010119-t1x9gknd 4040 22 because because IN cord-010119-t1x9gknd 4040 23 of of IN cord-010119-t1x9gknd 4040 24 frozen frozen JJ cord-010119-t1x9gknd 4040 25 storage storage NN cord-010119-t1x9gknd 4040 26 and and CC cord-010119-t1x9gknd 4040 27 long long JJ cord-010119-t1x9gknd 4040 28 thawing thawing NN cord-010119-t1x9gknd 4040 29 time time NN cord-010119-t1x9gknd 4040 30 . . . cord-010119-t1x9gknd 4041 1 Spray spray NN cord-010119-t1x9gknd 4041 2 - - HYPH cord-010119-t1x9gknd 4041 3 dried dry VBN cord-010119-t1x9gknd 4041 4 plasma plasma NN cord-010119-t1x9gknd 4041 5 ( ( -LRB- cord-010119-t1x9gknd 4041 6 ODP ODP NNP cord-010119-t1x9gknd 4041 7 , , , cord-010119-t1x9gknd 4042 1 On on IN cord-010119-t1x9gknd 4042 2 Demand Demand NNP cord-010119-t1x9gknd 4042 3 Plasma Plasma NNP cord-010119-t1x9gknd 4042 4 ) ) -RRB- cord-010119-t1x9gknd 4042 5 is be VBZ cord-010119-t1x9gknd 4042 6 potentially potentially RB cord-010119-t1x9gknd 4042 7 superior superior JJ cord-010119-t1x9gknd 4042 8 because because IN cord-010119-t1x9gknd 4042 9 it -PRON- PRP cord-010119-t1x9gknd 4042 10 may may MD cord-010119-t1x9gknd 4042 11 be be VB cord-010119-t1x9gknd 4042 12 stored store VBN cord-010119-t1x9gknd 4042 13 under under IN cord-010119-t1x9gknd 4042 14 refrigeration refrigeration NN cord-010119-t1x9gknd 4042 15 near near IN cord-010119-t1x9gknd 4042 16 the the DT cord-010119-t1x9gknd 4042 17 patient patient NN cord-010119-t1x9gknd 4042 18 and and CC cord-010119-t1x9gknd 4042 19 reconstituted reconstitute VBN cord-010119-t1x9gknd 4042 20 in in IN cord-010119-t1x9gknd 4042 21 minutes minute NNS cord-010119-t1x9gknd 4042 22 at at IN cord-010119-t1x9gknd 4042 23 the the DT cord-010119-t1x9gknd 4042 24 point point NN cord-010119-t1x9gknd 4042 25 - - HYPH cord-010119-t1x9gknd 4042 26 of of IN cord-010119-t1x9gknd 4042 27 - - HYPH cord-010119-t1x9gknd 4042 28 care care NN cord-010119-t1x9gknd 4042 29 . . . cord-010119-t1x9gknd 4043 1 The the DT cord-010119-t1x9gknd 4043 2 objective objective NN cord-010119-t1x9gknd 4043 3 of of IN cord-010119-t1x9gknd 4043 4 this this DT cord-010119-t1x9gknd 4043 5 study study NN cord-010119-t1x9gknd 4043 6 is be VBZ cord-010119-t1x9gknd 4043 7 to to TO cord-010119-t1x9gknd 4043 8 determine determine VB cord-010119-t1x9gknd 4043 9 if if IN cord-010119-t1x9gknd 4043 10 ODP ODP NNP cord-010119-t1x9gknd 4043 11 can can MD cord-010119-t1x9gknd 4043 12 be be VB cord-010119-t1x9gknd 4043 13 consistently consistently RB cord-010119-t1x9gknd 4043 14 manufactured manufacture VBN cord-010119-t1x9gknd 4043 15 at at IN cord-010119-t1x9gknd 4043 16 a a DT cord-010119-t1x9gknd 4043 17 blood blood NN cord-010119-t1x9gknd 4043 18 center center NN cord-010119-t1x9gknd 4043 19 with with IN cord-010119-t1x9gknd 4043 20 key key JJ cord-010119-t1x9gknd 4043 21 proteins protein NNS cord-010119-t1x9gknd 4043 22 and and CC cord-010119-t1x9gknd 4043 23 coagulation coagulation NN cord-010119-t1x9gknd 4043 24 function function NN cord-010119-t1x9gknd 4043 25 comparable comparable JJ cord-010119-t1x9gknd 4043 26 to to IN cord-010119-t1x9gknd 4043 27 FFP FFP NNP cord-010119-t1x9gknd 4043 28 . . . cord-010119-t1x9gknd 4044 1 Study Study NNP cord-010119-t1x9gknd 4044 2 Design Design NNP cord-010119-t1x9gknd 4044 3 / / SYM cord-010119-t1x9gknd 4044 4 Methods method NNS cord-010119-t1x9gknd 4044 5 : : : cord-010119-t1x9gknd 4045 1 Units unit NNS cord-010119-t1x9gknd 4045 2 of of IN cord-010119-t1x9gknd 4045 3 never never RB cord-010119-t1x9gknd 4045 4 frozen frozen JJ cord-010119-t1x9gknd 4045 5 plasma plasma NN cord-010119-t1x9gknd 4045 6 collected collect VBN cord-010119-t1x9gknd 4045 7 at at IN cord-010119-t1x9gknd 4045 8 a a DT cord-010119-t1x9gknd 4045 9 blood blood NN cord-010119-t1x9gknd 4045 10 center center NN cord-010119-t1x9gknd 4045 11 were be VBD cord-010119-t1x9gknd 4045 12 processed process VBN cord-010119-t1x9gknd 4045 13 on on IN cord-010119-t1x9gknd 4045 14 - - HYPH cord-010119-t1x9gknd 4045 15 site site NN cord-010119-t1x9gknd 4045 16 at at IN cord-010119-t1x9gknd 4045 17 a a DT cord-010119-t1x9gknd 4045 18 fixed fix VBN cord-010119-t1x9gknd 4045 19 volume volume NN cord-010119-t1x9gknd 4045 20 into into IN cord-010119-t1x9gknd 4045 21 ODP ODP NNP cord-010119-t1x9gknd 4045 22 using use VBG cord-010119-t1x9gknd 4045 23 Velico Velico NNP cord-010119-t1x9gknd 4045 24 's 's POS cord-010119-t1x9gknd 4045 25 spray spray NN cord-010119-t1x9gknd 4045 26 dryer dryer NN cord-010119-t1x9gknd 4045 27 . . . cord-010119-t1x9gknd 4046 1 ODP ODP NNP cord-010119-t1x9gknd 4046 2 ( ( -LRB- cord-010119-t1x9gknd 4046 3 n n NN cord-010119-t1x9gknd 4046 4 5 5 CD cord-010119-t1x9gknd 4046 5 60 60 CD cord-010119-t1x9gknd 4046 6 ) ) -RRB- cord-010119-t1x9gknd 4046 7 and and CC cord-010119-t1x9gknd 4046 8 paired pair VBD cord-010119-t1x9gknd 4046 9 FFP FFP NNP cord-010119-t1x9gknd 4046 10 aliquots aliquot NNS cord-010119-t1x9gknd 4046 11 were be VBD cord-010119-t1x9gknd 4046 12 stored store VBN cord-010119-t1x9gknd 4046 13 for for IN cord-010119-t1x9gknd 4046 14 31 31 CD cord-010119-t1x9gknd 4046 15 - - SYM cord-010119-t1x9gknd 4046 16 33 33 CD cord-010119-t1x9gknd 4046 17 days day NNS cord-010119-t1x9gknd 4046 18 at at IN cord-010119-t1x9gknd 4046 19 2 2 CD cord-010119-t1x9gknd 4046 20 - - HYPH cord-010119-t1x9gknd 4046 21 68C 68C NNS cord-010119-t1x9gknd 4046 22 and and CC cord-010119-t1x9gknd 4046 23 -188C -188c NN cord-010119-t1x9gknd 4046 24 , , , cord-010119-t1x9gknd 4046 25 respectively respectively RB cord-010119-t1x9gknd 4046 26 , , , cord-010119-t1x9gknd 4046 27 reconstituted reconstitute VBN cord-010119-t1x9gknd 4046 28 with with IN cord-010119-t1x9gknd 4046 29 a a DT cord-010119-t1x9gknd 4046 30 fixed fix VBN cord-010119-t1x9gknd 4046 31 volume volume NN cord-010119-t1x9gknd 4046 32 of of IN cord-010119-t1x9gknd 4046 33 rehydration rehydration NN cord-010119-t1x9gknd 4046 34 fluid fluid NN cord-010119-t1x9gknd 4046 35 ( ( -LRB- cord-010119-t1x9gknd 4046 36 sterile sterile JJ cord-010119-t1x9gknd 4046 37 water water NN cord-010119-t1x9gknd 4046 38 for for IN cord-010119-t1x9gknd 4046 39 injection injection NN cord-010119-t1x9gknd 4046 40 ) ) -RRB- cord-010119-t1x9gknd 4046 41 , , , cord-010119-t1x9gknd 4046 42 and and CC cord-010119-t1x9gknd 4046 43 extensively extensively RB cord-010119-t1x9gknd 4046 44 characterized characterize VBN cord-010119-t1x9gknd 4046 45 with with IN cord-010119-t1x9gknd 4046 46 respect respect NN cord-010119-t1x9gknd 4046 47 to to IN cord-010119-t1x9gknd 4046 48 the the DT cord-010119-t1x9gknd 4046 49 levels level NNS cord-010119-t1x9gknd 4046 50 of of IN cord-010119-t1x9gknd 4046 51 hemostatic hemostatic JJ cord-010119-t1x9gknd 4046 52 proteins protein NNS cord-010119-t1x9gknd 4046 53 , , , cord-010119-t1x9gknd 4046 54 coagulation coagulation NN cord-010119-t1x9gknd 4046 55 and and CC cord-010119-t1x9gknd 4046 56 complement complement NN cord-010119-t1x9gknd 4046 57 activation activation NN cord-010119-t1x9gknd 4046 58 markers marker NNS cord-010119-t1x9gknd 4046 59 , , , cord-010119-t1x9gknd 4046 60 and and CC cord-010119-t1x9gknd 4046 61 clotting clotting NN cord-010119-t1x9gknd 4046 62 performance performance NN cord-010119-t1x9gknd 4046 63 . . . cord-010119-t1x9gknd 4047 1 The the DT cord-010119-t1x9gknd 4047 2 volumes volume NNS cord-010119-t1x9gknd 4047 3 of of IN cord-010119-t1x9gknd 4047 4 processed process VBN cord-010119-t1x9gknd 4047 5 plasma plasma NN cord-010119-t1x9gknd 4047 6 and and CC cord-010119-t1x9gknd 4047 7 rehydration rehydration NN cord-010119-t1x9gknd 4047 8 fluid fluid NN cord-010119-t1x9gknd 4047 9 were be VBD cord-010119-t1x9gknd 4047 10 pre pre JJ cord-010119-t1x9gknd 4047 11 - - JJ cord-010119-t1x9gknd 4047 12 determined determined JJ cord-010119-t1x9gknd 4047 13 ensuring ensure VBG cord-010119-t1x9gknd 4047 14 similar similar JJ cord-010119-t1x9gknd 4047 15 total total JJ cord-010119-t1x9gknd 4047 16 protein protein NN cord-010119-t1x9gknd 4047 17 concentration concentration NN cord-010119-t1x9gknd 4047 18 in in IN cord-010119-t1x9gknd 4047 19 reconstituted reconstitute VBN cord-010119-t1x9gknd 4047 20 ODP ODP NNP cord-010119-t1x9gknd 4047 21 and and CC cord-010119-t1x9gknd 4047 22 FFP FFP NNP cord-010119-t1x9gknd 4047 23 for for IN cord-010119-t1x9gknd 4047 24 direct direct JJ cord-010119-t1x9gknd 4047 25 comparison comparison NN cord-010119-t1x9gknd 4047 26 . . . cord-010119-t1x9gknd 4048 1 Results result NNS cord-010119-t1x9gknd 4048 2 / / SYM cord-010119-t1x9gknd 4048 3 Findings finding NNS cord-010119-t1x9gknd 4048 4 : : : cord-010119-t1x9gknd 4049 1 Compared compare VBN cord-010119-t1x9gknd 4049 2 to to IN cord-010119-t1x9gknd 4049 3 FFP FFP NNP cord-010119-t1x9gknd 4049 4 , , , cord-010119-t1x9gknd 4049 5 ODP ODP NNP cord-010119-t1x9gknd 4049 6 had have VBD cord-010119-t1x9gknd 4049 7 ! ! . cord-010119-t1x9gknd 4050 1 80 80 CD cord-010119-t1x9gknd 4050 2 % % NN cord-010119-t1x9gknd 4050 3 levels level NNS cord-010119-t1x9gknd 4050 4 of of IN cord-010119-t1x9gknd 4050 5 functional functional JJ cord-010119-t1x9gknd 4050 6 clotting clotting NN cord-010119-t1x9gknd 4050 7 factors factor NNS cord-010119-t1x9gknd 4050 8 ( ( -LRB- cord-010119-t1x9gknd 4050 9 fibrinogen fibrinogen NN cord-010119-t1x9gknd 4050 10 , , , cord-010119-t1x9gknd 4050 11 factors factor NNS cord-010119-t1x9gknd 4050 12 II II NNP cord-010119-t1x9gknd 4050 13 , , , cord-010119-t1x9gknd 4050 14 V v NN cord-010119-t1x9gknd 4050 15 , , , cord-010119-t1x9gknd 4050 16 VII VII NNP cord-010119-t1x9gknd 4050 17 , , , cord-010119-t1x9gknd 4050 18 VIII VIII NNP cord-010119-t1x9gknd 4050 19 , , , cord-010119-t1x9gknd 4050 20 IX IX NNP cord-010119-t1x9gknd 4050 21 , , , cord-010119-t1x9gknd 4050 22 X X NNP cord-010119-t1x9gknd 4050 23 , , , cord-010119-t1x9gknd 4050 24 XI XI NNP cord-010119-t1x9gknd 4050 25 and and CC cord-010119-t1x9gknd 4050 26 XII XII NNP cord-010119-t1x9gknd 4050 27 ) ) -RRB- cord-010119-t1x9gknd 4050 28 , , , cord-010119-t1x9gknd 4050 29 plasminogen plasminogen NN cord-010119-t1x9gknd 4050 30 , , , cord-010119-t1x9gknd 4050 31 and and CC cord-010119-t1x9gknd 4050 32 protease protease NN cord-010119-t1x9gknd 4050 33 inhibitors inhibitor NNS cord-010119-t1x9gknd 4050 34 ( ( -LRB- cord-010119-t1x9gknd 4050 35 antithrombin antithrombin NN cord-010119-t1x9gknd 4050 36 III III NNP cord-010119-t1x9gknd 4050 37 , , , cord-010119-t1x9gknd 4050 38 protein protein NN cord-010119-t1x9gknd 4050 39 C C NNP cord-010119-t1x9gknd 4050 40 , , , cord-010119-t1x9gknd 4050 41 protein protein NN cord-010119-t1x9gknd 4050 42 S S NNP cord-010119-t1x9gknd 4050 43 ; ; : cord-010119-t1x9gknd 4050 44 plasmin plasmin NNP cord-010119-t1x9gknd 4050 45 , , , cord-010119-t1x9gknd 4050 46 C1 C1 NNP cord-010119-t1x9gknd 4050 47 esterase esterase NN cord-010119-t1x9gknd 4050 48 and and CC cord-010119-t1x9gknd 4050 49 alpha alpha NN cord-010119-t1x9gknd 4050 50 1-proteniase 1-proteniase CD cord-010119-t1x9gknd 4050 51 inhibitors inhibitor NNS cord-010119-t1x9gknd 4050 52 ) ) -RRB- cord-010119-t1x9gknd 4050 53 . . . cord-010119-t1x9gknd 4051 1 The the DT cord-010119-t1x9gknd 4051 2 level level NN cord-010119-t1x9gknd 4051 3 of of IN cord-010119-t1x9gknd 4051 4 factor factor NN cord-010119-t1x9gknd 4051 5 XIII XIII NNP cord-010119-t1x9gknd 4051 6 in in IN cord-010119-t1x9gknd 4051 7 ODP ODP NNP cord-010119-t1x9gknd 4051 8 was be VBD cord-010119-t1x9gknd 4051 9 slightly slightly RB cord-010119-t1x9gknd 4051 10 lower low JJR cord-010119-t1x9gknd 4051 11 , , , cord-010119-t1x9gknd 4051 12 about about RB cord-010119-t1x9gknd 4051 13 70 70 CD cord-010119-t1x9gknd 4051 14 % % NN cord-010119-t1x9gknd 4051 15 of of IN cord-010119-t1x9gknd 4051 16 FFP FFP NNP cord-010119-t1x9gknd 4051 17 by by IN cord-010119-t1x9gknd 4051 18 both both DT cord-010119-t1x9gknd 4051 19 activity activity NN cord-010119-t1x9gknd 4051 20 and and CC cord-010119-t1x9gknd 4051 21 antigen antigen NN cord-010119-t1x9gknd 4051 22 assays assay NNS cord-010119-t1x9gknd 4051 23 . . . cord-010119-t1x9gknd 4052 1 ODP ODP NNP cord-010119-t1x9gknd 4052 2 was be VBD cord-010119-t1x9gknd 4052 3 identical identical JJ cord-010119-t1x9gknd 4052 4 to to IN cord-010119-t1x9gknd 4052 5 FFP FFP NNP cord-010119-t1x9gknd 4052 6 in in IN cord-010119-t1x9gknd 4052 7 the the DT cord-010119-t1x9gknd 4052 8 levels level NNS cord-010119-t1x9gknd 4052 9 of of IN cord-010119-t1x9gknd 4052 10 albumin albumin NN cord-010119-t1x9gknd 4052 11 , , , cord-010119-t1x9gknd 4052 12 immunoglobulins immunoglobulin NNS cord-010119-t1x9gknd 4052 13 ( ( -LRB- cord-010119-t1x9gknd 4052 14 IgA IgA NNP cord-010119-t1x9gknd 4052 15 , , , cord-010119-t1x9gknd 4052 16 IgG IgG NNP cord-010119-t1x9gknd 4052 17 and and CC cord-010119-t1x9gknd 4052 18 IgM IgM NNP cord-010119-t1x9gknd 4052 19 ) ) -RRB- cord-010119-t1x9gknd 4052 20 , , , cord-010119-t1x9gknd 4052 21 lipoproteins lipoprotein NNS cord-010119-t1x9gknd 4052 22 , , , cord-010119-t1x9gknd 4052 23 calcium calcium NN cord-010119-t1x9gknd 4052 24 , , , cord-010119-t1x9gknd 4052 25 citrate citrate NN cord-010119-t1x9gknd 4052 26 , , , cord-010119-t1x9gknd 4052 27 and and CC cord-010119-t1x9gknd 4052 28 coagulation coagulation NN cord-010119-t1x9gknd 4052 29 proteins protein NNS cord-010119-t1x9gknd 4052 30 evaluated evaluate VBN cord-010119-t1x9gknd 4052 31 by by IN cord-010119-t1x9gknd 4052 32 antigen antigen NN cord-010119-t1x9gknd 4052 33 assays assay NNS cord-010119-t1x9gknd 4052 34 except except IN cord-010119-t1x9gknd 4052 35 for for IN cord-010119-t1x9gknd 4052 36 factor factor NN cord-010119-t1x9gknd 4052 37 XIII XIII NNP cord-010119-t1x9gknd 4052 38 . . . cord-010119-t1x9gknd 4053 1 The the DT cord-010119-t1x9gknd 4053 2 levels level NNS cord-010119-t1x9gknd 4053 3 of of IN cord-010119-t1x9gknd 4053 4 the the DT cord-010119-t1x9gknd 4053 5 markers marker NNS cord-010119-t1x9gknd 4053 6 for for IN cord-010119-t1x9gknd 4053 7 coagulation coagulation NN cord-010119-t1x9gknd 4054 1 ( ( -LRB- cord-010119-t1x9gknd 4054 2 thrombin thrombin NN cord-010119-t1x9gknd 4054 3 - - HYPH cord-010119-t1x9gknd 4054 4 antithrombin antithrombin NN cord-010119-t1x9gknd 4054 5 , , , cord-010119-t1x9gknd 4054 6 prothrombin prothrombin NN cord-010119-t1x9gknd 4054 7 fragments fragment VBZ cord-010119-t1x9gknd 4054 8 I1II i1ii RB cord-010119-t1x9gknd 4054 9 and and CC cord-010119-t1x9gknd 4054 10 Ddimer Ddimer NNP cord-010119-t1x9gknd 4054 11 ) ) -RRB- cord-010119-t1x9gknd 4054 12 and and CC cord-010119-t1x9gknd 4054 13 complement complement VB cord-010119-t1x9gknd 4054 14 ( ( -LRB- cord-010119-t1x9gknd 4054 15 C3a c3a NN cord-010119-t1x9gknd 4054 16 and and CC cord-010119-t1x9gknd 4054 17 C5a C5a NNS cord-010119-t1x9gknd 4054 18 ) ) -RRB- cord-010119-t1x9gknd 4054 19 activation activation NN cord-010119-t1x9gknd 4054 20 in in IN cord-010119-t1x9gknd 4054 21 ODP ODP NNP cord-010119-t1x9gknd 4054 22 remained remain VBD cord-010119-t1x9gknd 4054 23 similar similar JJ cord-010119-t1x9gknd 4054 24 to to IN cord-010119-t1x9gknd 4054 25 FFP FFP NNP cord-010119-t1x9gknd 4054 26 . . . cord-010119-t1x9gknd 4055 1 ODP ODP NNP cord-010119-t1x9gknd 4055 2 was be VBD cord-010119-t1x9gknd 4055 3 equivalent equivalent JJ cord-010119-t1x9gknd 4055 4 to to IN cord-010119-t1x9gknd 4055 5 FFP FFP NNP cord-010119-t1x9gknd 4055 6 when when WRB cord-010119-t1x9gknd 4055 7 assessed assess VBN cord-010119-t1x9gknd 4055 8 by by IN cord-010119-t1x9gknd 4055 9 aPTT aPTT NNP cord-010119-t1x9gknd 4055 10 , , , cord-010119-t1x9gknd 4055 11 PT PT NNP cord-010119-t1x9gknd 4055 12 and and CC cord-010119-t1x9gknd 4055 13 thrombelastography thrombelastography NN cord-010119-t1x9gknd 4055 14 . . . cord-010119-t1x9gknd 4056 1 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 4056 2 2017 2017 CD cord-010119-t1x9gknd 4056 3 Vol Vol NNP cord-010119-t1x9gknd 4056 4 . . . cord-010119-t1x9gknd 4057 1 57 57 CD cord-010119-t1x9gknd 4058 1 Supplement supplement NN cord-010119-t1x9gknd 4058 2 S3 S3 NNP cord-010119-t1x9gknd 4058 3 ABSTRACT abstract JJ cord-010119-t1x9gknd 4058 4 Spray spray NN cord-010119-t1x9gknd 4058 5 - - HYPH cord-010119-t1x9gknd 4058 6 drying drying NN cord-010119-t1x9gknd 4058 7 fragmented fragment VBD cord-010119-t1x9gknd 4058 8 a a DT cord-010119-t1x9gknd 4058 9 substantial substantial JJ cord-010119-t1x9gknd 4058 10 number number NN cord-010119-t1x9gknd 4058 11 of of IN cord-010119-t1x9gknd 4058 12 high high JJ cord-010119-t1x9gknd 4058 13 molecular molecular JJ cord-010119-t1x9gknd 4058 14 weight weight NN cord-010119-t1x9gknd 4058 15 von von NNP cord-010119-t1x9gknd 4058 16 Willebrand Willebrand NNP cord-010119-t1x9gknd 4058 17 factor factor NN cord-010119-t1x9gknd 4058 18 ( ( -LRB- cord-010119-t1x9gknd 4058 19 vWF vWF NNP cord-010119-t1x9gknd 4058 20 ) ) -RRB- cord-010119-t1x9gknd 4058 21 multimers multimer VBZ cord-010119-t1x9gknd 4058 22 into into IN cord-010119-t1x9gknd 4058 23 smaller small JJR cord-010119-t1x9gknd 4058 24 ones one NNS cord-010119-t1x9gknd 4058 25 , , , cord-010119-t1x9gknd 4058 26 leading lead VBG cord-010119-t1x9gknd 4058 27 to to IN cord-010119-t1x9gknd 4058 28 a a DT cord-010119-t1x9gknd 4058 29 net net JJ cord-010119-t1x9gknd 4058 30 increase increase NN cord-010119-t1x9gknd 4058 31 of of IN cord-010119-t1x9gknd 4058 32 vWF vwf NN cord-010119-t1x9gknd 4058 33 multimers multimer NNS cord-010119-t1x9gknd 4058 34 in in IN cord-010119-t1x9gknd 4058 35 ODP ODP NNP cord-010119-t1x9gknd 4058 36 . . . cord-010119-t1x9gknd 4059 1 The the DT cord-010119-t1x9gknd 4059 2 size size NN cord-010119-t1x9gknd 4059 3 re re NN cord-010119-t1x9gknd 4059 4 - - NN cord-010119-t1x9gknd 4059 5 distribution distribution NN cord-010119-t1x9gknd 4059 6 reduced reduce VBD cord-010119-t1x9gknd 4059 7 the the DT cord-010119-t1x9gknd 4059 8 vWF vWF NNP cord-010119-t1x9gknd 4059 9 ristocetin ristocetin JJ cord-010119-t1x9gknd 4059 10 cofactor cofactor NN cord-010119-t1x9gknd 4059 11 activity activity NN cord-010119-t1x9gknd 4059 12 ( ( -LRB- cord-010119-t1x9gknd 4059 13 vWF vwf IN cord-010119-t1x9gknd 4059 14 : : : cord-010119-t1x9gknd 4059 15 RCo RCo NNP cord-010119-t1x9gknd 4059 16 ) ) -RRB- cord-010119-t1x9gknd 4059 17 to to IN cord-010119-t1x9gknd 4059 18 62 62 CD cord-010119-t1x9gknd 4059 19 % % NN cord-010119-t1x9gknd 4059 20 in in IN cord-010119-t1x9gknd 4059 21 ODP ODP NNP cord-010119-t1x9gknd 4059 22 relative relative NN cord-010119-t1x9gknd 4059 23 to to IN cord-010119-t1x9gknd 4059 24 FFP FFP NNP cord-010119-t1x9gknd 4059 25 , , , cord-010119-t1x9gknd 4059 26 but but CC cord-010119-t1x9gknd 4059 27 had have VBD cord-010119-t1x9gknd 4059 28 no no DT cord-010119-t1x9gknd 4059 29 impact impact NN cord-010119-t1x9gknd 4059 30 on on IN cord-010119-t1x9gknd 4059 31 vWF vWF NNP cord-010119-t1x9gknd 4059 32 antigen antigen NN cord-010119-t1x9gknd 4059 33 and and CC cord-010119-t1x9gknd 4059 34 factor factor NN cord-010119-t1x9gknd 4059 35 VIII VIII NNP cord-010119-t1x9gknd 4059 36 function function NN cord-010119-t1x9gknd 4059 37 ( ( -LRB- cord-010119-t1x9gknd 4059 38 stabilized stabilize VBN cord-010119-t1x9gknd 4059 39 by by IN cord-010119-t1x9gknd 4059 40 vWF vwf NN cord-010119-t1x9gknd 4059 41 ) ) -RRB- cord-010119-t1x9gknd 4059 42 . . . cord-010119-t1x9gknd 4060 1 vWF vwf IN cord-010119-t1x9gknd 4060 2 - - HYPH cord-010119-t1x9gknd 4060 3 specific specific JJ cord-010119-t1x9gknd 4060 4 studies study NNS cord-010119-t1x9gknd 4060 5 have have VBP cord-010119-t1x9gknd 4060 6 shown show VBN cord-010119-t1x9gknd 4060 7 that that IN cord-010119-t1x9gknd 4060 8 ODP ODP NNP cord-010119-t1x9gknd 4060 9 retains retain VBZ cord-010119-t1x9gknd 4060 10 hemostatic hemostatic JJ cord-010119-t1x9gknd 4060 11 function function NN cord-010119-t1x9gknd 4060 12 in in IN cord-010119-t1x9gknd 4060 13 supporting support VBG cord-010119-t1x9gknd 4060 14 platelet platelet NN cord-010119-t1x9gknd 4060 15 adhesion adhesion NN cord-010119-t1x9gknd 4060 16 and and CC cord-010119-t1x9gknd 4060 17 aggregation aggregation NN cord-010119-t1x9gknd 4060 18 ( ( -LRB- cord-010119-t1x9gknd 4060 19 see see VB cord-010119-t1x9gknd 4060 20 abstracts abstract NNS cord-010119-t1x9gknd 4060 21 by by IN cord-010119-t1x9gknd 4060 22 Meledeo Meledeo NNP cord-010119-t1x9gknd 4060 23 et et NNP cord-010119-t1x9gknd 4060 24 al al NNP cord-010119-t1x9gknd 4060 25 / / SYM cord-010119-t1x9gknd 4060 26 US US NNP cord-010119-t1x9gknd 4060 27 Army Army NNP cord-010119-t1x9gknd 4060 28 Institute Institute NNP cord-010119-t1x9gknd 4060 29 of of IN cord-010119-t1x9gknd 4060 30 Surgical Surgical NNP cord-010119-t1x9gknd 4060 31 Research Research NNP cord-010119-t1x9gknd 4060 32 and and CC cord-010119-t1x9gknd 4060 33 Bercovitz Bercovitz NNP cord-010119-t1x9gknd 4060 34 et et NNP cord-010119-t1x9gknd 4060 35 al al NNP cord-010119-t1x9gknd 4060 36 / / SYM cord-010119-t1x9gknd 4060 37 Blood Blood NNP cord-010119-t1x9gknd 4060 38 Center Center NNP cord-010119-t1x9gknd 4060 39 of of IN cord-010119-t1x9gknd 4060 40 Wisconsin Wisconsin NNP cord-010119-t1x9gknd 4060 41 ) ) -RRB- cord-010119-t1x9gknd 4060 42 . . . cord-010119-t1x9gknd 4061 1 Conclusion conclusion NN cord-010119-t1x9gknd 4061 2 : : : cord-010119-t1x9gknd 4061 3 ODP ODP NNP cord-010119-t1x9gknd 4061 4 can can MD cord-010119-t1x9gknd 4061 5 be be VB cord-010119-t1x9gknd 4061 6 manufactured manufacture VBN cord-010119-t1x9gknd 4061 7 at at IN cord-010119-t1x9gknd 4061 8 a a DT cord-010119-t1x9gknd 4061 9 blood blood NN cord-010119-t1x9gknd 4061 10 center center NN cord-010119-t1x9gknd 4061 11 with with IN cord-010119-t1x9gknd 4061 12 a a DT cord-010119-t1x9gknd 4061 13 quality quality NN cord-010119-t1x9gknd 4061 14 comparable comparable JJ cord-010119-t1x9gknd 4061 15 to to IN cord-010119-t1x9gknd 4061 16 that that DT cord-010119-t1x9gknd 4061 17 of of IN cord-010119-t1x9gknd 4061 18 FFP FFP NNP cord-010119-t1x9gknd 4061 19 . . . cord-010119-t1x9gknd 4062 1 Future future JJ cord-010119-t1x9gknd 4062 2 studies study NNS cord-010119-t1x9gknd 4062 3 will will MD cord-010119-t1x9gknd 4062 4 determine determine VB cord-010119-t1x9gknd 4062 5 if if IN cord-010119-t1x9gknd 4062 6 the the DT cord-010119-t1x9gknd 4062 7 product product NN cord-010119-t1x9gknd 4062 8 is be VBZ cord-010119-t1x9gknd 4062 9 bioequivalent bioequivalent VBN cord-010119-t1x9gknd 4062 10 to to IN cord-010119-t1x9gknd 4062 11 FFP FFP NNP cord-010119-t1x9gknd 4062 12 and and CC cord-010119-t1x9gknd 4062 13 comparable comparable JJ cord-010119-t1x9gknd 4062 14 in in IN cord-010119-t1x9gknd 4062 15 safety safety NN cord-010119-t1x9gknd 4062 16 and and CC cord-010119-t1x9gknd 4062 17 efficacy efficacy NN cord-010119-t1x9gknd 4062 18 . . . cord-010119-t1x9gknd 4063 1 Background Background NNP cord-010119-t1x9gknd 4063 2 / / SYM cord-010119-t1x9gknd 4063 3 Case Case NNP cord-010119-t1x9gknd 4063 4 Studies Studies NNPS cord-010119-t1x9gknd 4063 5 : : : cord-010119-t1x9gknd 4064 1 The the DT cord-010119-t1x9gknd 4064 2 collection collection NN cord-010119-t1x9gknd 4064 3 time time NN cord-010119-t1x9gknd 4064 4 of of IN cord-010119-t1x9gknd 4064 5 whole whole JJ cord-010119-t1x9gknd 4064 6 blood blood NN cord-010119-t1x9gknd 4064 7 is be VBZ cord-010119-t1x9gknd 4064 8 , , , cord-010119-t1x9gknd 4064 9 according accord VBG cord-010119-t1x9gknd 4064 10 to to IN cord-010119-t1x9gknd 4064 11 European European NNP cord-010119-t1x9gknd 4064 12 Guidelines Guidelines NNPS cord-010119-t1x9gknd 4064 13 , , , cord-010119-t1x9gknd 4064 14 limited limit VBN cord-010119-t1x9gknd 4064 15 to to IN cord-010119-t1x9gknd 4064 16 15 15 CD cord-010119-t1x9gknd 4064 17 minutes minute NNS cord-010119-t1x9gknd 4064 18 . . . cord-010119-t1x9gknd 4065 1 In in IN cord-010119-t1x9gknd 4065 2 addition addition NN cord-010119-t1x9gknd 4065 3 , , , cord-010119-t1x9gknd 4065 4 donations donation NNS cord-010119-t1x9gknd 4065 5 with with IN cord-010119-t1x9gknd 4065 6 collection collection NN cord-010119-t1x9gknd 4065 7 times time NNS cord-010119-t1x9gknd 4065 8 between between IN cord-010119-t1x9gknd 4065 9 12 12 CD cord-010119-t1x9gknd 4065 10 and and CC cord-010119-t1x9gknd 4065 11 15 15 CD cord-010119-t1x9gknd 4065 12 minutes minute NNS cord-010119-t1x9gknd 4065 13 should should MD cord-010119-t1x9gknd 4065 14 not not RB cord-010119-t1x9gknd 4065 15 be be VB cord-010119-t1x9gknd 4065 16 used use VBN cord-010119-t1x9gknd 4065 17 for for IN cord-010119-t1x9gknd 4065 18 preparation preparation NN cord-010119-t1x9gknd 4065 19 of of IN cord-010119-t1x9gknd 4065 20 platelet platelet NN cord-010119-t1x9gknd 4065 21 ( ( -LRB- cord-010119-t1x9gknd 4065 22 PLT PLT NNP cord-010119-t1x9gknd 4065 23 ) ) -RRB- cord-010119-t1x9gknd 4065 24 concentrates concentrate VBZ cord-010119-t1x9gknd 4065 25 ( ( -LRB- cord-010119-t1x9gknd 4065 26 PC pc NN cord-010119-t1x9gknd 4065 27 ) ) -RRB- cord-010119-t1x9gknd 4065 28 because because IN cord-010119-t1x9gknd 4065 29 of of IN cord-010119-t1x9gknd 4065 30 the the DT cord-010119-t1x9gknd 4065 31 chance chance NN cord-010119-t1x9gknd 4065 32 of of IN cord-010119-t1x9gknd 4065 33 too too RB cord-010119-t1x9gknd 4065 34 much much JJ cord-010119-t1x9gknd 4065 35 activation activation NN cord-010119-t1x9gknd 4065 36 of of IN cord-010119-t1x9gknd 4065 37 PLT PLT NNP cord-010119-t1x9gknd 4065 38 . . . cord-010119-t1x9gknd 4066 1 It -PRON- PRP cord-010119-t1x9gknd 4066 2 seems seem VBZ cord-010119-t1x9gknd 4066 3 justified justified JJ cord-010119-t1x9gknd 4066 4 to to TO cord-010119-t1x9gknd 4066 5 re re VB cord-010119-t1x9gknd 4066 6 - - VB cord-010119-t1x9gknd 4066 7 evaluate evaluate VB cord-010119-t1x9gknd 4066 8 the the DT cord-010119-t1x9gknd 4066 9 quality quality NN cord-010119-t1x9gknd 4066 10 of of IN cord-010119-t1x9gknd 4066 11 PLT PLT NNP cord-010119-t1x9gknd 4066 12 from from IN cord-010119-t1x9gknd 4066 13 these these DT cord-010119-t1x9gknd 4066 14 donations donation NNS cord-010119-t1x9gknd 4066 15 because because IN cord-010119-t1x9gknd 4066 16 new new JJ cord-010119-t1x9gknd 4066 17 generations generation NNS cord-010119-t1x9gknd 4066 18 collection collection NN cord-010119-t1x9gknd 4066 19 systems system NNS cord-010119-t1x9gknd 4066 20 and and CC cord-010119-t1x9gknd 4066 21 mixers mixer NNS cord-010119-t1x9gknd 4066 22 were be VBD cord-010119-t1x9gknd 4066 23 introduced introduce VBN cord-010119-t1x9gknd 4066 24 , , , cord-010119-t1x9gknd 4066 25 including include VBG cord-010119-t1x9gknd 4066 26 a a DT cord-010119-t1x9gknd 4066 27 more more RBR cord-010119-t1x9gknd 4066 28 efficient efficient JJ cord-010119-t1x9gknd 4066 29 needle needle NN cord-010119-t1x9gknd 4066 30 . . . cord-010119-t1x9gknd 4067 1 The the DT cord-010119-t1x9gknd 4067 2 aim aim NN cord-010119-t1x9gknd 4067 3 of of IN cord-010119-t1x9gknd 4067 4 this this DT cord-010119-t1x9gknd 4067 5 study study NN cord-010119-t1x9gknd 4067 6 was be VBD cord-010119-t1x9gknd 4067 7 to to TO cord-010119-t1x9gknd 4067 8 investigate investigate VB cord-010119-t1x9gknd 4067 9 the the DT cord-010119-t1x9gknd 4067 10 in in FW cord-010119-t1x9gknd 4067 11 vitro vitro FW cord-010119-t1x9gknd 4067 12 quality quality NN cord-010119-t1x9gknd 4067 13 of of IN cord-010119-t1x9gknd 4067 14 PC pc NN cord-010119-t1x9gknd 4067 15 prepared prepare VBN cord-010119-t1x9gknd 4067 16 from from IN cord-010119-t1x9gknd 4067 17 12 12 CD cord-010119-t1x9gknd 4067 18 - - SYM cord-010119-t1x9gknd 4067 19 15 15 CD cord-010119-t1x9gknd 4067 20 minutes minute NNS cord-010119-t1x9gknd 4067 21 buffy buffy NNP cord-010119-t1x9gknd 4067 22 coats coat NNS cord-010119-t1x9gknd 4067 23 ( ( -LRB- cord-010119-t1x9gknd 4067 24 BC BC NNP cord-010119-t1x9gknd 4067 25 ) ) -RRB- cord-010119-t1x9gknd 4067 26 with with IN cord-010119-t1x9gknd 4067 27 the the DT cord-010119-t1x9gknd 4067 28 aim aim NN cord-010119-t1x9gknd 4067 29 to to TO cord-010119-t1x9gknd 4067 30 prevent prevent VB cord-010119-t1x9gknd 4067 31 unnecessary unnecessary JJ cord-010119-t1x9gknd 4067 32 discarding discarding NN cord-010119-t1x9gknd 4067 33 of of IN cord-010119-t1x9gknd 4067 34 BC BC NNP cord-010119-t1x9gknd 4067 35 and and CC cord-010119-t1x9gknd 4067 36 to to TO cord-010119-t1x9gknd 4067 37 simplify simplify VB cord-010119-t1x9gknd 4067 38 the the DT cord-010119-t1x9gknd 4067 39 total total JJ cord-010119-t1x9gknd 4067 40 blood blood NN cord-010119-t1x9gknd 4067 41 bank bank NN cord-010119-t1x9gknd 4067 42 process process NN cord-010119-t1x9gknd 4067 43 . . . cord-010119-t1x9gknd 4068 1 Study Study NNP cord-010119-t1x9gknd 4068 2 Design Design NNP cord-010119-t1x9gknd 4068 3 / / SYM cord-010119-t1x9gknd 4068 4 Method method NN cord-010119-t1x9gknd 4068 5 : : : cord-010119-t1x9gknd 4069 1 Single single JJ cord-010119-t1x9gknd 4069 2 - - HYPH cord-010119-t1x9gknd 4069 3 donor donor NN cord-010119-t1x9gknd 4069 4 PC pc NN cord-010119-t1x9gknd 4069 5 ( ( -LRB- cord-010119-t1x9gknd 4069 6 sPC spc XX cord-010119-t1x9gknd 4069 7 , , , cord-010119-t1x9gknd 4069 8 n56 n56 NN cord-010119-t1x9gknd 4069 9 ) ) -RRB- cord-010119-t1x9gknd 4069 10 were be VBD cord-010119-t1x9gknd 4069 11 prepared prepare VBN cord-010119-t1x9gknd 4069 12 from from IN cord-010119-t1x9gknd 4069 13 one one CD cord-010119-t1x9gknd 4069 14 12 12 CD cord-010119-t1x9gknd 4069 15 - - SYM cord-010119-t1x9gknd 4069 16 15 15 CD cord-010119-t1x9gknd 4069 17 minutes minute NNS cord-010119-t1x9gknd 4069 18 BC BC NNP cord-010119-t1x9gknd 4069 19 and and CC cord-010119-t1x9gknd 4069 20 60 60 CD cord-010119-t1x9gknd 4069 21 mL ml NN cord-010119-t1x9gknd 4069 22 of of IN cord-010119-t1x9gknd 4069 23 autologous autologous JJ cord-010119-t1x9gknd 4069 24 plasma plasma NN cord-010119-t1x9gknd 4069 25 in in IN cord-010119-t1x9gknd 4069 26 a a DT cord-010119-t1x9gknd 4069 27 600 600 CD cord-010119-t1x9gknd 4069 28 mL ml NN cord-010119-t1x9gknd 4069 29 PVC pvc NN cord-010119-t1x9gknd 4069 30 - - HYPH cord-010119-t1x9gknd 4069 31 DEHP dehp NN cord-010119-t1x9gknd 4069 32 container container NN cord-010119-t1x9gknd 4069 33 . . . cord-010119-t1x9gknd 4070 1 As as IN cord-010119-t1x9gknd 4070 2 a a DT cord-010119-t1x9gknd 4070 3 reference reference NN cord-010119-t1x9gknd 4070 4 , , , cord-010119-t1x9gknd 4070 5 sPC sPC NNS cord-010119-t1x9gknd 4070 6 from from IN cord-010119-t1x9gknd 4070 7 donations donation NNS cord-010119-t1x9gknd 4070 8 with with IN cord-010119-t1x9gknd 4070 9 collection collection NN cord-010119-t1x9gknd 4070 10 times time NNS cord-010119-t1x9gknd 4070 11 of of IN cord-010119-t1x9gknd 4070 12 < < NNP cord-010119-t1x9gknd 4070 13 12 12 CD cord-010119-t1x9gknd 4070 14 minutes minute NNS cord-010119-t1x9gknd 4070 15 were be VBD cord-010119-t1x9gknd 4070 16 prepared prepared JJ cord-010119-t1x9gknd 4070 17 ( ( -LRB- cord-010119-t1x9gknd 4070 18 n55 n55 NNP cord-010119-t1x9gknd 4070 19 ) ) -RRB- cord-010119-t1x9gknd 4070 20 . . . cord-010119-t1x9gknd 4071 1 In in IN cord-010119-t1x9gknd 4071 2 addition addition NN cord-010119-t1x9gknd 4071 3 , , , cord-010119-t1x9gknd 4071 4 PC PC NNP cord-010119-t1x9gknd 4071 5 were be VBD cord-010119-t1x9gknd 4071 6 prepared prepare VBN cord-010119-t1x9gknd 4071 7 from from IN cord-010119-t1x9gknd 4071 8 5 5 CD cord-010119-t1x9gknd 4071 9 BC BC NNP cord-010119-t1x9gknd 4071 10 , , , cord-010119-t1x9gknd 4071 11 of of IN cord-010119-t1x9gknd 4071 12 which which WDT cord-010119-t1x9gknd 4071 13 at at IN cord-010119-t1x9gknd 4071 14 least least JJS cord-010119-t1x9gknd 4071 15 4 4 CD cord-010119-t1x9gknd 4071 16 BC BC NNP cord-010119-t1x9gknd 4071 17 were be VBD cord-010119-t1x9gknd 4071 18 from from IN cord-010119-t1x9gknd 4071 19 12 12 CD cord-010119-t1x9gknd 4071 20 - - SYM cord-010119-t1x9gknd 4071 21 15 15 CD cord-010119-t1x9gknd 4071 22 minutes minute NNS cord-010119-t1x9gknd 4071 23 donations donation NNS cord-010119-t1x9gknd 4071 24 ( ( -LRB- cord-010119-t1x9gknd 4071 25 n55 n55 NNP cord-010119-t1x9gknd 4071 26 ) ) -RRB- cord-010119-t1x9gknd 4071 27 . . . cord-010119-t1x9gknd 4072 1 After after IN cord-010119-t1x9gknd 4072 2 pooling pool VBG cord-010119-t1x9gknd 4072 3 of of IN cord-010119-t1x9gknd 4072 4 the the DT cord-010119-t1x9gknd 4072 5 BC BC NNP cord-010119-t1x9gknd 4072 6 , , , cord-010119-t1x9gknd 4072 7 300 300 CD cord-010119-t1x9gknd 4072 8 mL ml NN cord-010119-t1x9gknd 4072 9 of of IN cord-010119-t1x9gknd 4072 10 PAS pas NN cord-010119-t1x9gknd 4072 11 - - HYPH cord-010119-t1x9gknd 4072 12 E E NNP cord-010119-t1x9gknd 4072 13 was be VBD cord-010119-t1x9gknd 4072 14 added add VBN cord-010119-t1x9gknd 4072 15 and and CC cord-010119-t1x9gknd 4072 16 a a DT cord-010119-t1x9gknd 4072 17 standard standard JJ cord-010119-t1x9gknd 4072 18 pooling pooling NN cord-010119-t1x9gknd 4072 19 set set VBN cord-010119-t1x9gknd 4072 20 with with IN cord-010119-t1x9gknd 4072 21 a a DT cord-010119-t1x9gknd 4072 22 PVC pvc NN cord-010119-t1x9gknd 4072 23 - - HYPH cord-010119-t1x9gknd 4072 24 BTHC BTHC NNP cord-010119-t1x9gknd 4072 25 storage storage NN cord-010119-t1x9gknd 4072 26 container container NN cord-010119-t1x9gknd 4072 27 was be VBD cord-010119-t1x9gknd 4072 28 used use VBN cord-010119-t1x9gknd 4072 29 for for IN cord-010119-t1x9gknd 4072 30 storage storage NN cord-010119-t1x9gknd 4072 31 of of IN cord-010119-t1x9gknd 4072 32 PC pc NN cord-010119-t1x9gknd 4072 33 . . . cord-010119-t1x9gknd 4073 1 All all DT cord-010119-t1x9gknd 4073 2 PC pc NN cord-010119-t1x9gknd 4073 3 were be VBD cord-010119-t1x9gknd 4073 4 stored store VBN cord-010119-t1x9gknd 4073 5 for for IN cord-010119-t1x9gknd 4073 6 8 8 CD cord-010119-t1x9gknd 4073 7 days day NNS cord-010119-t1x9gknd 4073 8 at at IN cord-010119-t1x9gknd 4073 9 22 22 CD cord-010119-t1x9gknd 4073 10 6 6 CD cord-010119-t1x9gknd 4073 11 28C 28C NNS cord-010119-t1x9gknd 4073 12 and and CC cord-010119-t1x9gknd 4073 13 sampled sample VBN cord-010119-t1x9gknd 4073 14 at at IN cord-010119-t1x9gknd 4073 15 regular regular JJ cord-010119-t1x9gknd 4073 16 intervals interval NNS cord-010119-t1x9gknd 4073 17 for for IN cord-010119-t1x9gknd 4073 18 determination determination NN cord-010119-t1x9gknd 4073 19 of of IN cord-010119-t1x9gknd 4073 20 the the DT cord-010119-t1x9gknd 4073 21 in in FW cord-010119-t1x9gknd 4073 22 vitro vitro FW cord-010119-t1x9gknd 4073 23 quality quality NN cord-010119-t1x9gknd 4073 24 . . . cord-010119-t1x9gknd 4074 1 Aggregation aggregation NN cord-010119-t1x9gknd 4074 2 tests test NNS cord-010119-t1x9gknd 4074 3 were be VBD cord-010119-t1x9gknd 4074 4 performed perform VBN cord-010119-t1x9gknd 4074 5 with with IN cord-010119-t1x9gknd 4074 6 Chronolog Chronolog NNP cord-010119-t1x9gknd 4074 7 ( ( -LRB- cord-010119-t1x9gknd 4074 8 ADP ADP NNP cord-010119-t1x9gknd 4074 9 or or CC cord-010119-t1x9gknd 4074 10 collagen collagen NN cord-010119-t1x9gknd 4074 11 ) ) -RRB- cord-010119-t1x9gknd 4074 12 and and CC cord-010119-t1x9gknd 4074 13 Multiplate Multiplate NNP cord-010119-t1x9gknd 4074 14 ( ( -LRB- cord-010119-t1x9gknd 4074 15 arachidonic arachidonic JJ cord-010119-t1x9gknd 4074 16 acid acid NN cord-010119-t1x9gknd 4074 17 ) ) -RRB- cord-010119-t1x9gknd 4074 18 aggregometers aggregometer NNS cord-010119-t1x9gknd 4074 19 . . . cord-010119-t1x9gknd 4075 1 Thromboelastography Thromboelastography NNP cord-010119-t1x9gknd 4075 2 ( ( -LRB- cord-010119-t1x9gknd 4075 3 TEG TEG NNP cord-010119-t1x9gknd 4075 4 ) ) -RRB- cord-010119-t1x9gknd 4075 5 , , , cord-010119-t1x9gknd 4075 6 using use VBG cord-010119-t1x9gknd 4075 7 kaolin kaolin NN cord-010119-t1x9gknd 4075 8 as as IN cord-010119-t1x9gknd 4075 9 an an DT cord-010119-t1x9gknd 4075 10 activator activator NN cord-010119-t1x9gknd 4075 11 , , , cord-010119-t1x9gknd 4075 12 was be VBD cord-010119-t1x9gknd 4075 13 applied apply VBN cord-010119-t1x9gknd 4075 14 for for IN cord-010119-t1x9gknd 4075 15 assessment assessment NN cord-010119-t1x9gknd 4075 16 of of IN cord-010119-t1x9gknd 4075 17 the the DT cord-010119-t1x9gknd 4075 18 overall overall JJ cord-010119-t1x9gknd 4075 19 clotting clotting NN cord-010119-t1x9gknd 4075 20 capacity capacity NN cord-010119-t1x9gknd 4075 21 . . . cord-010119-t1x9gknd 4076 1 Values value NNS cord-010119-t1x9gknd 4076 2 are be VBP cord-010119-t1x9gknd 4076 3 expressed express VBN cord-010119-t1x9gknd 4076 4 as as IN cord-010119-t1x9gknd 4076 5 mean6 mean6 NN cord-010119-t1x9gknd 4076 6 SD sd NN cord-010119-t1x9gknd 4076 7 . . . cord-010119-t1x9gknd 4077 1 A a DT cord-010119-t1x9gknd 4077 2 non non JJ cord-010119-t1x9gknd 4077 3 - - JJ cord-010119-t1x9gknd 4077 4 paired paired JJ cord-010119-t1x9gknd 4077 5 t t NN cord-010119-t1x9gknd 4077 6 - - HYPH cord-010119-t1x9gknd 4077 7 test test NN cord-010119-t1x9gknd 4077 8 or or CC cord-010119-t1x9gknd 4077 9 a a DT cord-010119-t1x9gknd 4077 10 Mann Mann NNP cord-010119-t1x9gknd 4077 11 - - HYPH cord-010119-t1x9gknd 4077 12 Whitney Whitney NNP cord-010119-t1x9gknd 4077 13 U U NNP cord-010119-t1x9gknd 4077 14 test test NN cord-010119-t1x9gknd 4077 15 was be VBD cord-010119-t1x9gknd 4077 16 applied apply VBN cord-010119-t1x9gknd 4077 17 for for IN cord-010119-t1x9gknd 4077 18 statistical statistical JJ cord-010119-t1x9gknd 4077 19 analyses analysis NNS cord-010119-t1x9gknd 4077 20 of of IN cord-010119-t1x9gknd 4077 21 normal normal JJ cord-010119-t1x9gknd 4077 22 or or CC cord-010119-t1x9gknd 4077 23 non non JJ cord-010119-t1x9gknd 4077 24 - - JJ cord-010119-t1x9gknd 4077 25 normal normal JJ cord-010119-t1x9gknd 4077 26 distributed distribute VBN cord-010119-t1x9gknd 4077 27 data datum NNS cord-010119-t1x9gknd 4077 28 respectively respectively RB cord-010119-t1x9gknd 4077 29 . . . cord-010119-t1x9gknd 4078 1 Results/ Results/ . cord-010119-t1x9gknd 4079 1 Finding finding NN cord-010119-t1x9gknd 4079 2 : : : cord-010119-t1x9gknd 4080 1 Volume volume NN cord-010119-t1x9gknd 4080 2 ( ( -LRB- cord-010119-t1x9gknd 4080 3 67 67 CD cord-010119-t1x9gknd 4080 4 6 6 CD cord-010119-t1x9gknd 4080 5 5 5 CD cord-010119-t1x9gknd 4080 6 vs. vs. NN cord-010119-t1x9gknd 4080 7 66 66 CD cord-010119-t1x9gknd 4080 8 6 6 CD cord-010119-t1x9gknd 4080 9 16 16 CD cord-010119-t1x9gknd 4080 10 mL ml NN cord-010119-t1x9gknd 4080 11 ) ) -RRB- cord-010119-t1x9gknd 4080 12 and and CC cord-010119-t1x9gknd 4080 13 platelet platelet NN cord-010119-t1x9gknd 4080 14 content content NN cord-010119-t1x9gknd 4080 15 ( ( -LRB- cord-010119-t1x9gknd 4080 16 74 74 CD cord-010119-t1x9gknd 4080 17 6 6 CD cord-010119-t1x9gknd 4080 18 11 11 CD cord-010119-t1x9gknd 4080 19 vs. vs. IN cord-010119-t1x9gknd 4080 20 71 71 CD cord-010119-t1x9gknd 4080 21 6 6 CD cord-010119-t1x9gknd 4080 22 15 15 CD cord-010119-t1x9gknd 4080 23 x10 x10 CD cord-010119-t1x9gknd 4080 24 9 9 CD cord-010119-t1x9gknd 4080 25 ) ) -RRB- cord-010119-t1x9gknd 4080 26 were be VBD cord-010119-t1x9gknd 4080 27 similar similar JJ cord-010119-t1x9gknd 4080 28 in in IN cord-010119-t1x9gknd 4080 29 both both DT cord-010119-t1x9gknd 4080 30 groups group NNS cord-010119-t1x9gknd 4080 31 . . . cord-010119-t1x9gknd 4081 1 At at IN cord-010119-t1x9gknd 4081 2 the the DT cord-010119-t1x9gknd 4081 3 end end NN cord-010119-t1x9gknd 4081 4 of of IN cord-010119-t1x9gknd 4081 5 storage storage NN cord-010119-t1x9gknd 4081 6 , , , cord-010119-t1x9gknd 4081 7 both both DT cord-010119-t1x9gknd 4081 8 groups group NNS cord-010119-t1x9gknd 4081 9 showed show VBD cord-010119-t1x9gknd 4081 10 comparable comparable JJ cord-010119-t1x9gknd 4081 11 in in IN cord-010119-t1x9gknd 4081 12 vitro vitro FW cord-010119-t1x9gknd 4081 13 quality quality NN cord-010119-t1x9gknd 4081 14 ( ( -LRB- cord-010119-t1x9gknd 4081 15 Day Day NNP cord-010119-t1x9gknd 4081 16 8 8 CD cord-010119-t1x9gknd 4081 17 , , , cord-010119-t1x9gknd 4081 18 pH(378C pH(378C NNP cord-010119-t1x9gknd 4081 19 ) ) -RRB- cord-010119-t1x9gknd 4081 20 : : : cord-010119-t1x9gknd 4081 21 6.84 6.84 CD cord-010119-t1x9gknd 4081 22 6 6 CD cord-010119-t1x9gknd 4081 23 0.16 0.16 CD cord-010119-t1x9gknd 4081 24 vs vs IN cord-010119-t1x9gknd 4081 25 6.83 6.83 CD cord-010119-t1x9gknd 4081 26 6 6 CD cord-010119-t1x9gknd 4081 27 0.17 0.17 CD cord-010119-t1x9gknd 4081 28 , , , cord-010119-t1x9gknd 4081 29 other other JJ cord-010119-t1x9gknd 4081 30 data datum NNS cord-010119-t1x9gknd 4081 31 not not RB cord-010119-t1x9gknd 4081 32 shown show VBN cord-010119-t1x9gknd 4081 33 ) ) -RRB- cord-010119-t1x9gknd 4081 34 . . . cord-010119-t1x9gknd 4082 1 No no DT cord-010119-t1x9gknd 4082 2 differences difference NNS cord-010119-t1x9gknd 4082 3 in in IN cord-010119-t1x9gknd 4082 4 aggregation aggregation NN cord-010119-t1x9gknd 4082 5 response response NN cord-010119-t1x9gknd 4082 6 after after IN cord-010119-t1x9gknd 4082 7 stimulation stimulation NN cord-010119-t1x9gknd 4082 8 with with IN cord-010119-t1x9gknd 4082 9 arachidonic arachidonic JJ cord-010119-t1x9gknd 4082 10 acid acid NN cord-010119-t1x9gknd 4082 11 , , , cord-010119-t1x9gknd 4082 12 ADP ADP NNP cord-010119-t1x9gknd 4082 13 or or CC cord-010119-t1x9gknd 4082 14 collagen collagen NN cord-010119-t1x9gknd 4082 15 were be VBD cord-010119-t1x9gknd 4082 16 measured measure VBN cord-010119-t1x9gknd 4082 17 . . . cord-010119-t1x9gknd 4083 1 TEG TEG NNP cord-010119-t1x9gknd 4083 2 parameters parameter NNS cord-010119-t1x9gknd 4083 3 in in IN cord-010119-t1x9gknd 4083 4 both both DT cord-010119-t1x9gknd 4083 5 groups group NNS cord-010119-t1x9gknd 4083 6 were be VBD cord-010119-t1x9gknd 4083 7 also also RB cord-010119-t1x9gknd 4083 8 comparable comparable JJ cord-010119-t1x9gknd 4083 9 . . . cord-010119-t1x9gknd 4084 1 The the DT cord-010119-t1x9gknd 4084 2 five five CD cord-010119-t1x9gknd 4084 3 - - HYPH cord-010119-t1x9gknd 4084 4 donor donor NN cord-010119-t1x9gknd 4084 5 PC pc NN cord-010119-t1x9gknd 4084 6 fulfilled fulfil VBD cord-010119-t1x9gknd 4084 7 all all DT cord-010119-t1x9gknd 4084 8 requirements requirement NNS cord-010119-t1x9gknd 4084 9 of of IN cord-010119-t1x9gknd 4084 10 European European NNP cord-010119-t1x9gknd 4084 11 Guidelines Guidelines NNPS cord-010119-t1x9gknd 4084 12 , , , cord-010119-t1x9gknd 4084 13 aside aside RB cord-010119-t1x9gknd 4084 14 from from IN cord-010119-t1x9gknd 4084 15 occurrence occurrence NN cord-010119-t1x9gknd 4084 16 of of IN cord-010119-t1x9gknd 4084 17 small small JJ cord-010119-t1x9gknd 4084 18 aggregates aggregate NNS cord-010119-t1x9gknd 4084 19 at at IN cord-010119-t1x9gknd 4084 20 Day day NN cord-010119-t1x9gknd 4084 21 6 6 CD cord-010119-t1x9gknd 4084 22 and/or and/or CC cord-010119-t1x9gknd 4084 23 8 8 CD cord-010119-t1x9gknd 4084 24 in in IN cord-010119-t1x9gknd 4084 25 2/5 2/5 CD cord-010119-t1x9gknd 4084 26 PC pc NN cord-010119-t1x9gknd 4084 27 ( ( -LRB- cord-010119-t1x9gknd 4084 28 possibly possibly RB cord-010119-t1x9gknd 4084 29 because because IN cord-010119-t1x9gknd 4084 30 sometimes sometimes RB cord-010119-t1x9gknd 4084 31 AB0 AB0 NNP cord-010119-t1x9gknd 4084 32 incompatibility incompatibility NN cord-010119-t1x9gknd 4084 33 was be VBD cord-010119-t1x9gknd 4084 34 accepted accept VBN cord-010119-t1x9gknd 4084 35 ) ) -RRB- cord-010119-t1x9gknd 4084 36 . . . cord-010119-t1x9gknd 4085 1 On on IN cord-010119-t1x9gknd 4085 2 Day Day NNP cord-010119-t1x9gknd 4085 3 8 8 CD cord-010119-t1x9gknd 4085 4 , , , cord-010119-t1x9gknd 4085 5 PLT PLT NNP cord-010119-t1x9gknd 4085 6 showed show VBD cord-010119-t1x9gknd 4085 7 low low JJ cord-010119-t1x9gknd 4085 8 CD62P cd62p NN cord-010119-t1x9gknd 4085 9 expression expression NN cord-010119-t1x9gknd 4085 10 ( ( -LRB- cord-010119-t1x9gknd 4085 11 17.1 17.1 CD cord-010119-t1x9gknd 4085 12 6 6 CD cord-010119-t1x9gknd 4085 13 1.8 1.8 CD cord-010119-t1x9gknd 4085 14 % % NN cord-010119-t1x9gknd 4085 15 ) ) -RRB- cord-010119-t1x9gknd 4085 16 and and CC cord-010119-t1x9gknd 4085 17 phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 4085 18 exposure exposure NN cord-010119-t1x9gknd 4085 19 ( ( -LRB- cord-010119-t1x9gknd 4085 20 Annexin Annexin NNP cord-010119-t1x9gknd 4085 21 V V NNP cord-010119-t1x9gknd 4085 22 binding binding NN cord-010119-t1x9gknd 4085 23 , , , cord-010119-t1x9gknd 4085 24 8.9 8.9 CD cord-010119-t1x9gknd 4085 25 6 6 CD cord-010119-t1x9gknd 4085 26 1.9 1.9 CD cord-010119-t1x9gknd 4085 27 % % NN cord-010119-t1x9gknd 4085 28 ) ) -RRB- cord-010119-t1x9gknd 4085 29 . . . cord-010119-t1x9gknd 4086 1 Hypotonic Hypotonic NNP cord-010119-t1x9gknd 4086 2 shock shock NN cord-010119-t1x9gknd 4086 3 response response NN cord-010119-t1x9gknd 4086 4 of of IN cord-010119-t1x9gknd 4086 5 platelets platelet NNS cord-010119-t1x9gknd 4086 6 was be VBD cord-010119-t1x9gknd 4086 7 comparable comparable JJ cord-010119-t1x9gknd 4086 8 with with IN cord-010119-t1x9gknd 4086 9 historical historical JJ cord-010119-t1x9gknd 4086 10 data datum NNS cord-010119-t1x9gknd 4086 11 . . . cord-010119-t1x9gknd 4087 1 Conclusion conclusion NN cord-010119-t1x9gknd 4087 2 : : : cord-010119-t1x9gknd 4087 3 Single single JJ cord-010119-t1x9gknd 4087 4 - - HYPH cord-010119-t1x9gknd 4087 5 PC pc NN cord-010119-t1x9gknd 4087 6 in in IN cord-010119-t1x9gknd 4087 7 plasma plasma NN cord-010119-t1x9gknd 4087 8 as as RB cord-010119-t1x9gknd 4087 9 well well RB cord-010119-t1x9gknd 4087 10 as as IN cord-010119-t1x9gknd 4087 11 five five CD cord-010119-t1x9gknd 4087 12 - - HYPH cord-010119-t1x9gknd 4087 13 donor donor NN cord-010119-t1x9gknd 4087 14 PC pc NN cord-010119-t1x9gknd 4087 15 in in IN cord-010119-t1x9gknd 4087 16 PAS pas NN cord-010119-t1x9gknd 4087 17 - - HYPH cord-010119-t1x9gknd 4087 18 E e NN cord-010119-t1x9gknd 4087 19 , , , cord-010119-t1x9gknd 4087 20 prepared prepare VBN cord-010119-t1x9gknd 4087 21 from from IN cord-010119-t1x9gknd 4087 22 12 12 CD cord-010119-t1x9gknd 4087 23 - - SYM cord-010119-t1x9gknd 4087 24 15 15 CD cord-010119-t1x9gknd 4087 25 minutes minute NNS cord-010119-t1x9gknd 4087 26 whole whole JJ cord-010119-t1x9gknd 4087 27 blood blood NN cord-010119-t1x9gknd 4087 28 donations donation NNS cord-010119-t1x9gknd 4087 29 had have VBD cord-010119-t1x9gknd 4087 30 a a DT cord-010119-t1x9gknd 4087 31 normal normal JJ cord-010119-t1x9gknd 4087 32 composition composition NN cord-010119-t1x9gknd 4087 33 and and CC cord-010119-t1x9gknd 4087 34 showed show VBD cord-010119-t1x9gknd 4087 35 good good JJ cord-010119-t1x9gknd 4087 36 in in IN cord-010119-t1x9gknd 4087 37 vitro vitro FW cord-010119-t1x9gknd 4087 38 quality quality NN cord-010119-t1x9gknd 4087 39 during during IN cord-010119-t1x9gknd 4087 40 8 8 CD cord-010119-t1x9gknd 4087 41 day day NN cord-010119-t1x9gknd 4087 42 storage storage NN cord-010119-t1x9gknd 4087 43 . . . cord-010119-t1x9gknd 4088 1 To to TO cord-010119-t1x9gknd 4088 2 substantiate substantiate VB cord-010119-t1x9gknd 4088 3 that that IN cord-010119-t1x9gknd 4088 4 the the DT cord-010119-t1x9gknd 4088 5 exclusion exclusion NN cord-010119-t1x9gknd 4088 6 of of IN cord-010119-t1x9gknd 4088 7 12 12 CD cord-010119-t1x9gknd 4088 8 - - SYM cord-010119-t1x9gknd 4088 9 15 15 CD cord-010119-t1x9gknd 4088 10 minutes minute NNS cord-010119-t1x9gknd 4088 11 donations donation NNS cord-010119-t1x9gknd 4088 12 for for IN cord-010119-t1x9gknd 4088 13 PC pc NN cord-010119-t1x9gknd 4088 14 preparation preparation NN cord-010119-t1x9gknd 4088 15 could could MD cord-010119-t1x9gknd 4088 16 be be VB cord-010119-t1x9gknd 4088 17 stopped stop VBN cord-010119-t1x9gknd 4088 18 , , , cord-010119-t1x9gknd 4088 19 further further JJ cord-010119-t1x9gknd 4088 20 studies study NNS cord-010119-t1x9gknd 4088 21 will will MD cord-010119-t1x9gknd 4088 22 be be VB cord-010119-t1x9gknd 4088 23 performed perform VBN cord-010119-t1x9gknd 4088 24 . . . cord-010119-t1x9gknd 4089 1 The the DT cord-010119-t1x9gknd 4089 2 Effects effect NNS cord-010119-t1x9gknd 4089 3 of of IN cord-010119-t1x9gknd 4089 4 a a DT cord-010119-t1x9gknd 4089 5 Pneumatic pneumatic JJ cord-010119-t1x9gknd 4089 6 Tube Tube NNP cord-010119-t1x9gknd 4089 7 System System NNP cord-010119-t1x9gknd 4089 8 on on IN cord-010119-t1x9gknd 4089 9 Red Red NNP cord-010119-t1x9gknd 4089 10 Blood Blood NNP cord-010119-t1x9gknd 4089 11 Cell Cell NNP cord-010119-t1x9gknd 4089 12 Units Units NNPS cord-010119-t1x9gknd 4089 13 Amy Amy NNP cord-010119-t1x9gknd 4089 14 Mata Mata NNP cord-010119-t1x9gknd 4090 1 * * NFP cord-010119-t1x9gknd 4090 2 1 1 CD cord-010119-t1x9gknd 4090 3 , , , cord-010119-t1x9gknd 4090 4 Jessie Jessie NNP cord-010119-t1x9gknd 4090 5 Miller Miller NNP cord-010119-t1x9gknd 4090 6 1 1 CD cord-010119-t1x9gknd 4090 7 , , , cord-010119-t1x9gknd 4091 1 Ranee Ranee NNP cord-010119-t1x9gknd 4091 2 Marie Marie NNP cord-010119-t1x9gknd 4091 3 Wannarka Wannarka NNP cord-010119-t1x9gknd 4091 4 - - HYPH cord-010119-t1x9gknd 4091 5 Farlinger Farlinger NNP cord-010119-t1x9gknd 4091 6 1 1 CD cord-010119-t1x9gknd 4091 7 , , , cord-010119-t1x9gknd 4091 8 Sandra Sandra NNP cord-010119-t1x9gknd 4091 9 Bryant Bryant NNP cord-010119-t1x9gknd 4091 10 1 1 CD cord-010119-t1x9gknd 4091 11 , , , cord-010119-t1x9gknd 4091 12 Scott Scott NNP cord-010119-t1x9gknd 4091 13 A A NNP cord-010119-t1x9gknd 4091 14 Hammel Hammel NNP cord-010119-t1x9gknd 4091 15 1 1 CD cord-010119-t1x9gknd 4091 16 , , , cord-010119-t1x9gknd 4091 17 Sherry Sherry NNP cord-010119-t1x9gknd 4091 18 Stern Stern NNP cord-010119-t1x9gknd 4091 19 1 1 CD cord-010119-t1x9gknd 4091 20 and and CC cord-010119-t1x9gknd 4091 21 Camille Camille NNP cord-010119-t1x9gknd 4091 22 van van NNP cord-010119-t1x9gknd 4091 23 Buskirk Buskirk NNP cord-010119-t1x9gknd 4091 24 2 2 CD cord-010119-t1x9gknd 4091 25 . . . cord-010119-t1x9gknd 4091 26 1 1 CD cord-010119-t1x9gknd 4091 27 Mayo Mayo NNP cord-010119-t1x9gknd 4091 28 Clinic Clinic NNP cord-010119-t1x9gknd 4091 29 , , , cord-010119-t1x9gknd 4091 30 2 2 CD cord-010119-t1x9gknd 4091 31 Mayo Mayo NNP cord-010119-t1x9gknd 4091 32 Clinic Clinic NNP cord-010119-t1x9gknd 4091 33 Rochester Rochester NNP cord-010119-t1x9gknd 4091 34 Background Background NNP cord-010119-t1x9gknd 4091 35 / / SYM cord-010119-t1x9gknd 4091 36 Case Case NNP cord-010119-t1x9gknd 4091 37 Studies Studies NNPS cord-010119-t1x9gknd 4091 38 : : : cord-010119-t1x9gknd 4092 1 The the DT cord-010119-t1x9gknd 4092 2 use use NN cord-010119-t1x9gknd 4092 3 of of IN cord-010119-t1x9gknd 4092 4 Pneumatic pneumatic JJ cord-010119-t1x9gknd 4092 5 Tube Tube NNP cord-010119-t1x9gknd 4092 6 Systems Systems NNPS cord-010119-t1x9gknd 4092 7 ( ( -LRB- cord-010119-t1x9gknd 4092 8 PTS PTS NNP cord-010119-t1x9gknd 4092 9 ) ) -RRB- cord-010119-t1x9gknd 4092 10 has have VBZ cord-010119-t1x9gknd 4092 11 become become VBN cord-010119-t1x9gknd 4092 12 commonplace commonplace JJ cord-010119-t1x9gknd 4092 13 in in IN cord-010119-t1x9gknd 4092 14 many many JJ cord-010119-t1x9gknd 4092 15 healthcare healthcare NN cord-010119-t1x9gknd 4092 16 facilities facility NNS cord-010119-t1x9gknd 4092 17 throughout throughout IN cord-010119-t1x9gknd 4092 18 the the DT cord-010119-t1x9gknd 4092 19 world world NN cord-010119-t1x9gknd 4092 20 . . . cord-010119-t1x9gknd 4093 1 The the DT cord-010119-t1x9gknd 4093 2 purpose purpose NN cord-010119-t1x9gknd 4093 3 of of IN cord-010119-t1x9gknd 4093 4 these these DT cord-010119-t1x9gknd 4093 5 systems system NNS cord-010119-t1x9gknd 4093 6 is be VBZ cord-010119-t1x9gknd 4093 7 to to TO cord-010119-t1x9gknd 4093 8 transport transport VB cord-010119-t1x9gknd 4093 9 products product NNS cord-010119-t1x9gknd 4093 10 and and CC cord-010119-t1x9gknd 4093 11 specimens specimen NNS cord-010119-t1x9gknd 4093 12 , , , cord-010119-t1x9gknd 4093 13 resulting result VBG cord-010119-t1x9gknd 4093 14 in in IN cord-010119-t1x9gknd 4093 15 reduced reduce VBN cord-010119-t1x9gknd 4093 16 turnaround turnaround NN cord-010119-t1x9gknd 4093 17 time time NN cord-010119-t1x9gknd 4093 18 for for IN cord-010119-t1x9gknd 4093 19 laboratory laboratory NN cord-010119-t1x9gknd 4093 20 testing testing NN cord-010119-t1x9gknd 4093 21 and and CC cord-010119-t1x9gknd 4093 22 to to TO cord-010119-t1x9gknd 4093 23 aid aid VB cord-010119-t1x9gknd 4093 24 in in IN cord-010119-t1x9gknd 4093 25 the the DT cord-010119-t1x9gknd 4093 26 timely timely JJ cord-010119-t1x9gknd 4093 27 delivery delivery NN cord-010119-t1x9gknd 4093 28 of of IN cord-010119-t1x9gknd 4093 29 patient patient JJ cord-010119-t1x9gknd 4093 30 care care NN cord-010119-t1x9gknd 4093 31 . . . cord-010119-t1x9gknd 4094 1 A a DT cord-010119-t1x9gknd 4094 2 downfall downfall NN cord-010119-t1x9gknd 4094 3 of of IN cord-010119-t1x9gknd 4094 4 PTSs pts NNS cord-010119-t1x9gknd 4094 5 is be VBZ cord-010119-t1x9gknd 4094 6 that that IN cord-010119-t1x9gknd 4094 7 they -PRON- PRP cord-010119-t1x9gknd 4094 8 have have VBP cord-010119-t1x9gknd 4094 9 the the DT cord-010119-t1x9gknd 4094 10 potential potential NN cord-010119-t1x9gknd 4094 11 to to TO cord-010119-t1x9gknd 4094 12 play play VB cord-010119-t1x9gknd 4094 13 a a DT cord-010119-t1x9gknd 4094 14 role role NN cord-010119-t1x9gknd 4094 15 in in IN cord-010119-t1x9gknd 4094 16 increased increase VBN cord-010119-t1x9gknd 4094 17 hemolysis hemolysis NN cord-010119-t1x9gknd 4094 18 . . . cord-010119-t1x9gknd 4095 1 While while IN cord-010119-t1x9gknd 4095 2 several several JJ cord-010119-t1x9gknd 4095 3 studies study NNS cord-010119-t1x9gknd 4095 4 have have VBP cord-010119-t1x9gknd 4095 5 been be VBN cord-010119-t1x9gknd 4095 6 published publish VBN cord-010119-t1x9gknd 4095 7 on on IN cord-010119-t1x9gknd 4095 8 the the DT cord-010119-t1x9gknd 4095 9 effects effect NNS cord-010119-t1x9gknd 4095 10 of of IN cord-010119-t1x9gknd 4095 11 PTSs pts NNS cord-010119-t1x9gknd 4095 12 on on IN cord-010119-t1x9gknd 4095 13 blood blood NN cord-010119-t1x9gknd 4095 14 specimens specimen NNS cord-010119-t1x9gknd 4095 15 , , , cord-010119-t1x9gknd 4095 16 there there EX cord-010119-t1x9gknd 4095 17 are be VBP cord-010119-t1x9gknd 4095 18 very very RB cord-010119-t1x9gknd 4095 19 few few JJ cord-010119-t1x9gknd 4095 20 that that WDT cord-010119-t1x9gknd 4095 21 address address VBP cord-010119-t1x9gknd 4095 22 the the DT cord-010119-t1x9gknd 4095 23 effects effect NNS cord-010119-t1x9gknd 4095 24 on on IN cord-010119-t1x9gknd 4095 25 blood blood NN cord-010119-t1x9gknd 4095 26 products product NNS cord-010119-t1x9gknd 4095 27 , , , cord-010119-t1x9gknd 4095 28 specifically specifically RB cord-010119-t1x9gknd 4095 29 red red JJ cord-010119-t1x9gknd 4095 30 blood blood NN cord-010119-t1x9gknd 4095 31 cells cell NNS cord-010119-t1x9gknd 4095 32 ( ( -LRB- cord-010119-t1x9gknd 4095 33 RBC RBC NNP cord-010119-t1x9gknd 4095 34 ) ) -RRB- cord-010119-t1x9gknd 4095 35 . . . cord-010119-t1x9gknd 4096 1 The the DT cord-010119-t1x9gknd 4096 2 objective objective NN cord-010119-t1x9gknd 4096 3 of of IN cord-010119-t1x9gknd 4096 4 this this DT cord-010119-t1x9gknd 4096 5 study study NN cord-010119-t1x9gknd 4096 6 was be VBD cord-010119-t1x9gknd 4096 7 twofold twofold JJ cord-010119-t1x9gknd 4096 8 : : : cord-010119-t1x9gknd 4096 9 to to TO cord-010119-t1x9gknd 4096 10 determine determine VB cord-010119-t1x9gknd 4096 11 if if IN cord-010119-t1x9gknd 4096 12 the the DT cord-010119-t1x9gknd 4096 13 PTS PTS NNP cord-010119-t1x9gknd 4096 14 that that WDT cord-010119-t1x9gknd 4096 15 is be VBZ cord-010119-t1x9gknd 4096 16 in in IN cord-010119-t1x9gknd 4096 17 use use NN cord-010119-t1x9gknd 4096 18 at at IN cord-010119-t1x9gknd 4096 19 our -PRON- PRP$ cord-010119-t1x9gknd 4096 20 facility facility NN cord-010119-t1x9gknd 4096 21 contributes contribute VBZ cord-010119-t1x9gknd 4096 22 to to IN cord-010119-t1x9gknd 4096 23 an an DT cord-010119-t1x9gknd 4096 24 increase increase NN cord-010119-t1x9gknd 4096 25 in in IN cord-010119-t1x9gknd 4096 26 hemolysis hemolysis NN cord-010119-t1x9gknd 4096 27 of of IN cord-010119-t1x9gknd 4096 28 RBC RBC NNP cord-010119-t1x9gknd 4096 29 units unit NNS cord-010119-t1x9gknd 4096 30 and and CC cord-010119-t1x9gknd 4096 31 to to TO cord-010119-t1x9gknd 4096 32 evaluate evaluate VB cord-010119-t1x9gknd 4096 33 how how WRB cord-010119-t1x9gknd 4096 34 the the DT cord-010119-t1x9gknd 4096 35 PTS PTS NNP cord-010119-t1x9gknd 4096 36 system system NN cord-010119-t1x9gknd 4096 37 affects affect VBZ cord-010119-t1x9gknd 4096 38 red red JJ cord-010119-t1x9gknd 4096 39 cell cell NN cord-010119-t1x9gknd 4096 40 microparticle microparticle NNP cord-010119-t1x9gknd 4096 41 ( ( -LRB- cord-010119-t1x9gknd 4096 42 RMP RMP NNP cord-010119-t1x9gknd 4096 43 ) ) -RRB- cord-010119-t1x9gknd 4096 44 levels level NNS cord-010119-t1x9gknd 4096 45 . . . cord-010119-t1x9gknd 4097 1 Study Study NNP cord-010119-t1x9gknd 4097 2 Design Design NNP cord-010119-t1x9gknd 4097 3 / / SYM cord-010119-t1x9gknd 4097 4 Method method NN cord-010119-t1x9gknd 4097 5 : : : cord-010119-t1x9gknd 4097 6 Forty forty CD cord-010119-t1x9gknd 4097 7 - - HYPH cord-010119-t1x9gknd 4097 8 one one CD cord-010119-t1x9gknd 4097 9 units unit NNS cord-010119-t1x9gknd 4097 10 of of IN cord-010119-t1x9gknd 4097 11 AS-3 AS-3 NNP cord-010119-t1x9gknd 4097 12 RBCs rbc NNS cord-010119-t1x9gknd 4097 13 , , , cord-010119-t1x9gknd 4097 14 20 20 CD cord-010119-t1x9gknd 4097 15 irradiated irradiate VBN cord-010119-t1x9gknd 4097 16 and and CC cord-010119-t1x9gknd 4097 17 21 21 CD cord-010119-t1x9gknd 4097 18 non non NNS cord-010119-t1x9gknd 4097 19 - - JJ cord-010119-t1x9gknd 4097 20 irradiated irradiated JJ cord-010119-t1x9gknd 4097 21 , , , cord-010119-t1x9gknd 4097 22 were be VBD cord-010119-t1x9gknd 4097 23 selected select VBN cord-010119-t1x9gknd 4097 24 for for IN cord-010119-t1x9gknd 4097 25 the the DT cord-010119-t1x9gknd 4097 26 study study NN cord-010119-t1x9gknd 4097 27 . . . cord-010119-t1x9gknd 4098 1 The the DT cord-010119-t1x9gknd 4098 2 units unit NNS cord-010119-t1x9gknd 4098 3 varied vary VBN cord-010119-t1x9gknd 4098 4 in in IN cord-010119-t1x9gknd 4098 5 age age NN cord-010119-t1x9gknd 4098 6 , , , cord-010119-t1x9gknd 4098 7 ranging range VBG cord-010119-t1x9gknd 4098 8 from from IN cord-010119-t1x9gknd 4098 9 2 2 CD cord-010119-t1x9gknd 4098 10 to to TO cord-010119-t1x9gknd 4098 11 42 42 CD cord-010119-t1x9gknd 4098 12 days day NNS cord-010119-t1x9gknd 4098 13 old old JJ cord-010119-t1x9gknd 4098 14 . . . cord-010119-t1x9gknd 4099 1 Specimens specimen NNS cord-010119-t1x9gknd 4099 2 were be VBD cord-010119-t1x9gknd 4099 3 obtained obtain VBN cord-010119-t1x9gknd 4099 4 from from IN cord-010119-t1x9gknd 4099 5 each each DT cord-010119-t1x9gknd 4099 6 unit unit NN cord-010119-t1x9gknd 4099 7 both both CC cord-010119-t1x9gknd 4099 8 prior prior RB cord-010119-t1x9gknd 4099 9 to to IN cord-010119-t1x9gknd 4099 10 and and CC cord-010119-t1x9gknd 4099 11 after after IN cord-010119-t1x9gknd 4099 12 being be VBG cord-010119-t1x9gknd 4099 13 transported transport VBN cord-010119-t1x9gknd 4099 14 through through IN cord-010119-t1x9gknd 4099 15 the the DT cord-010119-t1x9gknd 4099 16 PTS PTS NNP cord-010119-t1x9gknd 4099 17 , , , cord-010119-t1x9gknd 4099 18 which which WDT cord-010119-t1x9gknd 4099 19 runs run VBZ cord-010119-t1x9gknd 4099 20 underground underground RB cord-010119-t1x9gknd 4099 21 and and CC cord-010119-t1x9gknd 4099 22 spans span VBZ cord-010119-t1x9gknd 4099 23 the the DT cord-010119-t1x9gknd 4099 24 length length NN cord-010119-t1x9gknd 4099 25 of of IN cord-010119-t1x9gknd 4099 26 a a DT cord-010119-t1x9gknd 4099 27 mile mile NN cord-010119-t1x9gknd 4099 28 and and CC cord-010119-t1x9gknd 4099 29 a a DT cord-010119-t1x9gknd 4099 30 half half NN cord-010119-t1x9gknd 4099 31 . . . cord-010119-t1x9gknd 4100 1 Specimens specimen NNS cord-010119-t1x9gknd 4100 2 were be VBD cord-010119-t1x9gknd 4100 3 spun spin VBN cord-010119-t1x9gknd 4100 4 down down RP cord-010119-t1x9gknd 4100 5 and and CC cord-010119-t1x9gknd 4100 6 the the DT cord-010119-t1x9gknd 4100 7 plasma plasma NN cord-010119-t1x9gknd 4100 8 supernatant supernatant NN cord-010119-t1x9gknd 4100 9 was be VBD cord-010119-t1x9gknd 4100 10 removed remove VBN cord-010119-t1x9gknd 4100 11 . . . cord-010119-t1x9gknd 4101 1 All all DT cord-010119-t1x9gknd 4101 2 specimens specimen NNS cord-010119-t1x9gknd 4101 3 were be VBD cord-010119-t1x9gknd 4101 4 evaluated evaluate VBN cord-010119-t1x9gknd 4101 5 for for IN cord-010119-t1x9gknd 4101 6 plasma plasma NN cord-010119-t1x9gknd 4101 7 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4101 8 ( ( -LRB- cord-010119-t1x9gknd 4101 9 hgb hgb NNP cord-010119-t1x9gknd 4101 10 ) ) -RRB- cord-010119-t1x9gknd 4101 11 , , , cord-010119-t1x9gknd 4101 12 potassium potassium NN cord-010119-t1x9gknd 4101 13 ( ( -LRB- cord-010119-t1x9gknd 4101 14 K K NNP cord-010119-t1x9gknd 4101 15 ) ) -RRB- cord-010119-t1x9gknd 4101 16 , , , cord-010119-t1x9gknd 4101 17 hemolysis hemolysis NN cord-010119-t1x9gknd 4101 18 index index NN cord-010119-t1x9gknd 4101 19 ( ( -LRB- cord-010119-t1x9gknd 4101 20 HI HI NNP cord-010119-t1x9gknd 4101 21 ) ) -RRB- cord-010119-t1x9gknd 4101 22 , , , cord-010119-t1x9gknd 4101 23 and and CC cord-010119-t1x9gknd 4101 24 RMPs rmp NNS cord-010119-t1x9gknd 4101 25 . . . cord-010119-t1x9gknd 4102 1 The the DT cord-010119-t1x9gknd 4102 2 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 4102 3 signed sign VBD cord-010119-t1x9gknd 4102 4 - - HYPH cord-010119-t1x9gknd 4102 5 rank rank NN cord-010119-t1x9gknd 4102 6 test test NN cord-010119-t1x9gknd 4102 7 and and CC cord-010119-t1x9gknd 4102 8 p p NN cord-010119-t1x9gknd 4102 9 value value NN cord-010119-t1x9gknd 4102 10 were be VBD cord-010119-t1x9gknd 4102 11 used use VBN cord-010119-t1x9gknd 4102 12 to to TO cord-010119-t1x9gknd 4102 13 compare compare VB cord-010119-t1x9gknd 4102 14 the the DT cord-010119-t1x9gknd 4102 15 pre pre JJ cord-010119-t1x9gknd 4102 16 and and CC cord-010119-t1x9gknd 4102 17 post post JJ cord-010119-t1x9gknd 4102 18 values value NNS cord-010119-t1x9gknd 4102 19 . . . cord-010119-t1x9gknd 4103 1 Additional additional JJ cord-010119-t1x9gknd 4103 2 statistical statistical JJ cord-010119-t1x9gknd 4103 3 analysis analysis NN cord-010119-t1x9gknd 4103 4 was be VBD cord-010119-t1x9gknd 4103 5 performed perform VBN cord-010119-t1x9gknd 4103 6 to to TO cord-010119-t1x9gknd 4103 7 compare compare VB cord-010119-t1x9gknd 4103 8 the the DT cord-010119-t1x9gknd 4103 9 values value NNS cord-010119-t1x9gknd 4103 10 after after IN cord-010119-t1x9gknd 4103 11 adjusting adjust VBG cord-010119-t1x9gknd 4103 12 for for IN cord-010119-t1x9gknd 4103 13 age age NN cord-010119-t1x9gknd 4103 14 and and CC cord-010119-t1x9gknd 4103 15 irradiation irradiation NN cord-010119-t1x9gknd 4103 16 . . . cord-010119-t1x9gknd 4104 1 Results/ Results/ . cord-010119-t1x9gknd 4105 1 Finding finding NN cord-010119-t1x9gknd 4105 2 : : : cord-010119-t1x9gknd 4106 1 After after IN cord-010119-t1x9gknd 4106 2 sending send VBG cord-010119-t1x9gknd 4106 3 the the DT cord-010119-t1x9gknd 4106 4 RBC RBC NNP cord-010119-t1x9gknd 4106 5 units unit NNS cord-010119-t1x9gknd 4106 6 through through IN cord-010119-t1x9gknd 4106 7 the the DT cord-010119-t1x9gknd 4106 8 PTS PTS NNP cord-010119-t1x9gknd 4106 9 , , , cord-010119-t1x9gknd 4106 10 hgb hgb NNP cord-010119-t1x9gknd 4106 11 , , , cord-010119-t1x9gknd 4106 12 HI HI NNP cord-010119-t1x9gknd 4106 13 , , , cord-010119-t1x9gknd 4106 14 and and CC cord-010119-t1x9gknd 4106 15 RMPs rmp NNS cord-010119-t1x9gknd 4106 16 were be VBD cord-010119-t1x9gknd 4106 17 statistically statistically RB cord-010119-t1x9gknd 4106 18 ( ( -LRB- cord-010119-t1x9gknd 4106 19 p p NN cord-010119-t1x9gknd 4106 20 < < XX cord-010119-t1x9gknd 4106 21 0.05 0.05 CD cord-010119-t1x9gknd 4106 22 ) ) -RRB- cord-010119-t1x9gknd 4106 23 higher high JJR cord-010119-t1x9gknd 4106 24 than than IN cord-010119-t1x9gknd 4106 25 before before RB cord-010119-t1x9gknd 4106 26 . . . cord-010119-t1x9gknd 4107 1 When when WRB cord-010119-t1x9gknd 4107 2 adjusted adjust VBN cord-010119-t1x9gknd 4107 3 for for IN cord-010119-t1x9gknd 4107 4 irradiation irradiation NN cord-010119-t1x9gknd 4107 5 , , , cord-010119-t1x9gknd 4107 6 the the DT cord-010119-t1x9gknd 4107 7 same same JJ cord-010119-t1x9gknd 4107 8 analytes analyte NNS cord-010119-t1x9gknd 4107 9 remained remain VBD cord-010119-t1x9gknd 4107 10 statistically statistically RB cord-010119-t1x9gknd 4107 11 higher high JJR cord-010119-t1x9gknd 4107 12 , , , cord-010119-t1x9gknd 4107 13 however however RB cord-010119-t1x9gknd 4107 14 when when WRB cord-010119-t1x9gknd 4107 15 adjusted adjust VBN cord-010119-t1x9gknd 4107 16 for for IN cord-010119-t1x9gknd 4107 17 age age NN cord-010119-t1x9gknd 4107 18 , , , cord-010119-t1x9gknd 4107 19 the the DT cord-010119-t1x9gknd 4107 20 p p NN cord-010119-t1x9gknd 4107 21 - - HYPH cord-010119-t1x9gknd 4107 22 value value NN cord-010119-t1x9gknd 4107 23 was be VBD cord-010119-t1x9gknd 4107 24 only only RB cord-010119-t1x9gknd 4107 25 significant significant JJ cord-010119-t1x9gknd 4107 26 for for IN cord-010119-t1x9gknd 4107 27 hgb hgb NNP cord-010119-t1x9gknd 4107 28 and and CC cord-010119-t1x9gknd 4107 29 HI HI NNP cord-010119-t1x9gknd 4107 30 . . . cord-010119-t1x9gknd 4108 1 The the DT cord-010119-t1x9gknd 4108 2 K K NNP cord-010119-t1x9gknd 4108 3 values value NNS cord-010119-t1x9gknd 4108 4 did do VBD cord-010119-t1x9gknd 4108 5 not not RB cord-010119-t1x9gknd 4108 6 significantly significantly RB cord-010119-t1x9gknd 4108 7 change change VB cord-010119-t1x9gknd 4108 8 . . . cord-010119-t1x9gknd 4109 1 RMPs RMPs NNP cord-010119-t1x9gknd 4109 2 significantly significantly RB cord-010119-t1x9gknd 4109 3 increased increase VBD cord-010119-t1x9gknd 4109 4 , , , cord-010119-t1x9gknd 4109 5 but but CC cord-010119-t1x9gknd 4109 6 only only RB cord-010119-t1x9gknd 4109 7 if if IN cord-010119-t1x9gknd 4109 8 the the DT cord-010119-t1x9gknd 4109 9 units unit NNS cord-010119-t1x9gknd 4109 10 were be VBD cord-010119-t1x9gknd 4109 11 irradiated irradiate VBN cord-010119-t1x9gknd 4109 12 ( ( -LRB- cord-010119-t1x9gknd 4109 13 p50.02 p50.02 NN cord-010119-t1x9gknd 4109 14 ) ) -RRB- cord-010119-t1x9gknd 4109 15 . . . cord-010119-t1x9gknd 4110 1 ( ( -LRB- cord-010119-t1x9gknd 4110 2 Table table NN cord-010119-t1x9gknd 4110 3 ) ) -RRB- cord-010119-t1x9gknd 4111 1 Conclusion conclusion NN cord-010119-t1x9gknd 4111 2 : : : cord-010119-t1x9gknd 4112 1 The the DT cord-010119-t1x9gknd 4112 2 use use NN cord-010119-t1x9gknd 4112 3 of of IN cord-010119-t1x9gknd 4112 4 a a DT cord-010119-t1x9gknd 4112 5 PTS PTS NNP cord-010119-t1x9gknd 4112 6 provides provide VBZ cord-010119-t1x9gknd 4112 7 an an DT cord-010119-t1x9gknd 4112 8 effective effective JJ cord-010119-t1x9gknd 4112 9 means mean NNS cord-010119-t1x9gknd 4112 10 to to TO cord-010119-t1x9gknd 4112 11 transport transport VB cord-010119-t1x9gknd 4112 12 blood blood NN cord-010119-t1x9gknd 4112 13 products product NNS cord-010119-t1x9gknd 4112 14 ; ; : cord-010119-t1x9gknd 4112 15 however however RB cord-010119-t1x9gknd 4112 16 , , , cord-010119-t1x9gknd 4112 17 it -PRON- PRP cord-010119-t1x9gknd 4112 18 can can MD cord-010119-t1x9gknd 4112 19 contribute contribute VB cord-010119-t1x9gknd 4112 20 to to IN cord-010119-t1x9gknd 4112 21 biological biological JJ cord-010119-t1x9gknd 4112 22 changes change NNS cord-010119-t1x9gknd 4112 23 within within IN cord-010119-t1x9gknd 4112 24 RBC RBC NNP cord-010119-t1x9gknd 4112 25 units unit NNS cord-010119-t1x9gknd 4112 26 . . . cord-010119-t1x9gknd 4113 1 It -PRON- PRP cord-010119-t1x9gknd 4113 2 is be VBZ cord-010119-t1x9gknd 4113 3 uncertain uncertain JJ cord-010119-t1x9gknd 4113 4 at at IN cord-010119-t1x9gknd 4113 5 this this DT cord-010119-t1x9gknd 4113 6 time time NN cord-010119-t1x9gknd 4113 7 how how WRB cord-010119-t1x9gknd 4113 8 those those DT cord-010119-t1x9gknd 4113 9 changes change NNS cord-010119-t1x9gknd 4113 10 can can MD cord-010119-t1x9gknd 4113 11 affect affect VB cord-010119-t1x9gknd 4113 12 the the DT cord-010119-t1x9gknd 4113 13 outcome outcome NN cord-010119-t1x9gknd 4113 14 of of IN cord-010119-t1x9gknd 4113 15 patients patient NNS cord-010119-t1x9gknd 4113 16 who who WP cord-010119-t1x9gknd 4113 17 receive receive VBP cord-010119-t1x9gknd 4113 18 these these DT cord-010119-t1x9gknd 4113 19 products product NNS cord-010119-t1x9gknd 4113 20 . . . cord-010119-t1x9gknd 4114 1 Each each DT cord-010119-t1x9gknd 4114 2 PTS PTS NNP cord-010119-t1x9gknd 4114 3 system system NN cord-010119-t1x9gknd 4114 4 is be VBZ cord-010119-t1x9gknd 4114 5 different different JJ cord-010119-t1x9gknd 4114 6 in in IN cord-010119-t1x9gknd 4114 7 its -PRON- PRP$ cord-010119-t1x9gknd 4114 8 specifications specification NNS cord-010119-t1x9gknd 4114 9 and and CC cord-010119-t1x9gknd 4114 10 should should MD cord-010119-t1x9gknd 4114 11 be be VB cord-010119-t1x9gknd 4114 12 validated validate VBN cord-010119-t1x9gknd 4114 13 prior prior RB cord-010119-t1x9gknd 4114 14 to to IN cord-010119-t1x9gknd 4114 15 being be VBG cord-010119-t1x9gknd 4114 16 used use VBN cord-010119-t1x9gknd 4114 17 to to TO cord-010119-t1x9gknd 4114 18 transport transport VB cord-010119-t1x9gknd 4114 19 blood blood NN cord-010119-t1x9gknd 4114 20 products product NNS cord-010119-t1x9gknd 4114 21 . . . cord-010119-t1x9gknd 4115 1 Validation validation NN cord-010119-t1x9gknd 4115 2 of of IN cord-010119-t1x9gknd 4115 3 Factor Factor NNP cord-010119-t1x9gknd 4115 4 VIII VIII NNP cord-010119-t1x9gknd 4115 5 Levels level NNS cord-010119-t1x9gknd 4115 6 of of IN cord-010119-t1x9gknd 4115 7 Thawed Thawed NNP cord-010119-t1x9gknd 4115 8 Fresh Fresh NNP cord-010119-t1x9gknd 4115 9 Frozen Frozen NNP cord-010119-t1x9gknd 4115 10 Plasma Plasma NNP cord-010119-t1x9gknd 4115 11 after after IN cord-010119-t1x9gknd 4115 12 5 5 CD cord-010119-t1x9gknd 4115 13 Days day NNS cord-010119-t1x9gknd 4115 14 of of IN cord-010119-t1x9gknd 4115 15 Storage Storage NNP cord-010119-t1x9gknd 4115 16 Pei Pei NNP cord-010119-t1x9gknd 4115 17 Lun Lun NNP cord-010119-t1x9gknd 4115 18 Karen Karen NNP cord-010119-t1x9gknd 4115 19 Lim Lim NNP cord-010119-t1x9gknd 4115 20 * * NFP cord-010119-t1x9gknd 4115 21 1 1 CD cord-010119-t1x9gknd 4115 22 , , , cord-010119-t1x9gknd 4115 23 Erma Erma NNP cord-010119-t1x9gknd 4115 24 Sofia Sofia NNP cord-010119-t1x9gknd 4115 25 Sumardi Sumardi NNPS cord-010119-t1x9gknd 4115 26 1 1 CD cord-010119-t1x9gknd 4115 27 , , , cord-010119-t1x9gknd 4115 28 Isamar Isamar NNP cord-010119-t1x9gknd 4115 29 Eduardo Eduardo NNP cord-010119-t1x9gknd 4115 30 Ancheta Ancheta NNP cord-010119-t1x9gknd 4115 31 1 1 CD cord-010119-t1x9gknd 4115 32 , , , cord-010119-t1x9gknd 4115 33 Susan Susan NNP cord-010119-t1x9gknd 4115 34 Lim Lim NNP cord-010119-t1x9gknd 4115 35 2 2 CD cord-010119-t1x9gknd 4115 36 , , , cord-010119-t1x9gknd 4115 37 Christina Christina NNP cord-010119-t1x9gknd 4115 38 Yip Yip NNP cord-010119-t1x9gknd 4115 39 1 1 CD cord-010119-t1x9gknd 4115 40 , , , cord-010119-t1x9gknd 4115 41 Lip Lip NNP cord-010119-t1x9gknd 4115 42 Kun Kun NNP cord-010119-t1x9gknd 4115 43 Tan Tan NNP cord-010119-t1x9gknd 4115 44 2 2 CD cord-010119-t1x9gknd 4115 45 and and CC cord-010119-t1x9gknd 4115 46 Shir Shir NNP cord-010119-t1x9gknd 4115 47 Ying Ying NNP cord-010119-t1x9gknd 4115 48 Lee Lee NNP cord-010119-t1x9gknd 4115 49 3 3 CD cord-010119-t1x9gknd 4115 50 . . . cord-010119-t1x9gknd 4116 1 1 1 LS cord-010119-t1x9gknd 4116 2 National National NNP cord-010119-t1x9gknd 4116 3 University University NNP cord-010119-t1x9gknd 4116 4 Hospital Hospital NNP cord-010119-t1x9gknd 4116 5 Singapore Singapore NNP cord-010119-t1x9gknd 4116 6 , , , cord-010119-t1x9gknd 4116 7 2 2 CD cord-010119-t1x9gknd 4116 8 National National NNP cord-010119-t1x9gknd 4116 9 University University NNP cord-010119-t1x9gknd 4116 10 Hospital Hospital NNP cord-010119-t1x9gknd 4116 11 , , , cord-010119-t1x9gknd 4116 12 3 3 CD cord-010119-t1x9gknd 4116 13 National National NNP cord-010119-t1x9gknd 4116 14 University University NNP cord-010119-t1x9gknd 4116 15 Hospital Hospital NNP cord-010119-t1x9gknd 4116 16 , , , cord-010119-t1x9gknd 4116 17 Singapore Singapore NNP cord-010119-t1x9gknd 4116 18 Background Background NNP cord-010119-t1x9gknd 4116 19 / / SYM cord-010119-t1x9gknd 4116 20 Case Case NNP cord-010119-t1x9gknd 4116 21 Studies Studies NNPS cord-010119-t1x9gknd 4116 22 : : : cord-010119-t1x9gknd 4116 23 Plasma plasma NN cord-010119-t1x9gknd 4116 24 transfusion transfusion NN cord-010119-t1x9gknd 4116 25 is be VBZ cord-010119-t1x9gknd 4116 26 indicated indicate VBN cord-010119-t1x9gknd 4116 27 in in IN cord-010119-t1x9gknd 4116 28 patients patient NNS cord-010119-t1x9gknd 4116 29 with with IN cord-010119-t1x9gknd 4116 30 coagulation coagulation NN cord-010119-t1x9gknd 4116 31 factor factor NN cord-010119-t1x9gknd 4116 32 deficiencies deficiency NNS cord-010119-t1x9gknd 4116 33 and and CC cord-010119-t1x9gknd 4116 34 active active JJ cord-010119-t1x9gknd 4116 35 bleeding bleeding NN cord-010119-t1x9gknd 4116 36 , , , cord-010119-t1x9gknd 4116 37 or or CC cord-010119-t1x9gknd 4116 38 who who WP cord-010119-t1x9gknd 4116 39 are be VBP cord-010119-t1x9gknd 4116 40 about about JJ cord-010119-t1x9gknd 4116 41 to to TO cord-010119-t1x9gknd 4116 42 undergo undergo VB cord-010119-t1x9gknd 4116 43 an an DT cord-010119-t1x9gknd 4116 44 invasive invasive JJ cord-010119-t1x9gknd 4116 45 procedure procedure NN cord-010119-t1x9gknd 4116 46 . . . cord-010119-t1x9gknd 4117 1 Fresh Fresh NNP cord-010119-t1x9gknd 4117 2 Frozen Frozen NNP cord-010119-t1x9gknd 4117 3 Plasma Plasma NNP cord-010119-t1x9gknd 4117 4 ( ( -LRB- cord-010119-t1x9gknd 4117 5 FFP FFP NNP cord-010119-t1x9gknd 4117 6 ) ) -RRB- cord-010119-t1x9gknd 4117 7 has have VBZ cord-010119-t1x9gknd 4117 8 to to TO cord-010119-t1x9gknd 4117 9 be be VB cord-010119-t1x9gknd 4117 10 placed place VBN cord-010119-t1x9gknd 4117 11 in in IN cord-010119-t1x9gknd 4117 12 the the DT cord-010119-t1x9gknd 4117 13 freezer freezer NN cord-010119-t1x9gknd 4117 14 within within IN cord-010119-t1x9gknd 4117 15 8 8 CD cord-010119-t1x9gknd 4117 16 hours hour NNS cord-010119-t1x9gknd 4117 17 of of IN cord-010119-t1x9gknd 4117 18 processing processing NN cord-010119-t1x9gknd 4117 19 and and CC cord-010119-t1x9gknd 4117 20 stored store VBN cord-010119-t1x9gknd 4117 21 at at IN cord-010119-t1x9gknd 4117 22 -188C -188c NN cord-010119-t1x9gknd 4117 23 or or CC cord-010119-t1x9gknd 4117 24 colder cold JJR cord-010119-t1x9gknd 4117 25 in in IN cord-010119-t1x9gknd 4117 26 order order NN cord-010119-t1x9gknd 4117 27 to to TO cord-010119-t1x9gknd 4117 28 preserve preserve VB cord-010119-t1x9gknd 4117 29 its -PRON- PRP$ cord-010119-t1x9gknd 4117 30 coagulation coagulation NN cord-010119-t1x9gknd 4117 31 factors factor NNS cord-010119-t1x9gknd 4117 32 . . . cord-010119-t1x9gknd 4118 1 Thawed Thawed NNP cord-010119-t1x9gknd 4118 2 FFP FFP NNP cord-010119-t1x9gknd 4118 3 has have VBZ cord-010119-t1x9gknd 4118 4 an an DT cord-010119-t1x9gknd 4118 5 expiration expiration NN cord-010119-t1x9gknd 4118 6 period period NN cord-010119-t1x9gknd 4118 7 of of IN cord-010119-t1x9gknd 4118 8 24 24 CD cord-010119-t1x9gknd 4118 9 hours hour NNS cord-010119-t1x9gknd 4118 10 hence hence RB cord-010119-t1x9gknd 4118 11 to to TO cord-010119-t1x9gknd 4118 12 reduce reduce VB cord-010119-t1x9gknd 4118 13 wastage wastage NN cord-010119-t1x9gknd 4118 14 , , , cord-010119-t1x9gknd 4118 15 this this DT cord-010119-t1x9gknd 4118 16 study study NN cord-010119-t1x9gknd 4118 17 aims aim VBZ cord-010119-t1x9gknd 4118 18 to to TO cord-010119-t1x9gknd 4118 19 investigate investigate VB cord-010119-t1x9gknd 4118 20 Factor Factor NNP cord-010119-t1x9gknd 4118 21 VIII VIII NNP cord-010119-t1x9gknd 4118 22 ( ( -LRB- cord-010119-t1x9gknd 4118 23 FVIII FVIII NNP cord-010119-t1x9gknd 4118 24 ) ) -RRB- cord-010119-t1x9gknd 4118 25 activity activity NN cord-010119-t1x9gknd 4118 26 in in IN cord-010119-t1x9gknd 4118 27 thawed thaw VBN cord-010119-t1x9gknd 4118 28 plasma plasma NN cord-010119-t1x9gknd 4118 29 stored store VBN cord-010119-t1x9gknd 4118 30 for for IN cord-010119-t1x9gknd 4118 31 5 5 CD cord-010119-t1x9gknd 4118 32 days day NNS cord-010119-t1x9gknd 4118 33 and and CC cord-010119-t1x9gknd 4118 34 kept keep VBD cord-010119-t1x9gknd 4118 35 at at IN cord-010119-t1x9gknd 4118 36 1 1 CD cord-010119-t1x9gknd 4118 37 to to IN cord-010119-t1x9gknd 4118 38 68C. 68c. CD cord-010119-t1x9gknd 4118 39 FVIII FVIII NNP cord-010119-t1x9gknd 4118 40 was be VBD cord-010119-t1x9gknd 4118 41 chosen choose VBN cord-010119-t1x9gknd 4118 42 as as IN cord-010119-t1x9gknd 4118 43 it -PRON- PRP cord-010119-t1x9gknd 4118 44 is be VBZ cord-010119-t1x9gknd 4118 45 an an DT cord-010119-t1x9gknd 4118 46 important important JJ cord-010119-t1x9gknd 4118 47 coagulation coagulation NN cord-010119-t1x9gknd 4118 48 factor factor NN cord-010119-t1x9gknd 4118 49 in in IN cord-010119-t1x9gknd 4118 50 correcting correct VBG cord-010119-t1x9gknd 4118 51 coagulopathies coagulopathie NNS cord-010119-t1x9gknd 4118 52 . . . cord-010119-t1x9gknd 4119 1 Arbitrary arbitrary JJ cord-010119-t1x9gknd 4119 2 FVIII FVIII NNP cord-010119-t1x9gknd 4119 3 level level NN cord-010119-t1x9gknd 4119 4 acceptance acceptance NN cord-010119-t1x9gknd 4119 5 limit limit NN cord-010119-t1x9gknd 4119 6 was be VBD cord-010119-t1x9gknd 4119 7 set set VBN cord-010119-t1x9gknd 4119 8 as as RB cord-010119-t1x9gknd 4119 9 not not RB cord-010119-t1x9gknd 4119 10 less less JJR cord-010119-t1x9gknd 4119 11 than than IN cord-010119-t1x9gknd 4119 12 50 50 CD cord-010119-t1x9gknd 4119 13 IU IU NNP cord-010119-t1x9gknd 4119 14 / / SYM cord-010119-t1x9gknd 4119 15 dL. dl. CC cord-010119-t1x9gknd 4119 16 Study Study NNP cord-010119-t1x9gknd 4119 17 Design Design NNP cord-010119-t1x9gknd 4119 18 / / SYM cord-010119-t1x9gknd 4119 19 Method method NN cord-010119-t1x9gknd 4119 20 : : : cord-010119-t1x9gknd 4120 1 Randomly randomly RB cord-010119-t1x9gknd 4120 2 selected select VBN cord-010119-t1x9gknd 4120 3 units unit NNS cord-010119-t1x9gknd 4120 4 of of IN cord-010119-t1x9gknd 4120 5 FFP FFP NNP cord-010119-t1x9gknd 4120 6 ( ( -LRB- cord-010119-t1x9gknd 4120 7 n510 n510 NNP cord-010119-t1x9gknd 4120 8 ) ) -RRB- cord-010119-t1x9gknd 4120 9 were be VBD cord-010119-t1x9gknd 4120 10 measured measure VBN cord-010119-t1x9gknd 4120 11 for for IN cord-010119-t1x9gknd 4120 12 FVIII FVIII NNP cord-010119-t1x9gknd 4120 13 concentration concentration NN cord-010119-t1x9gknd 4120 14 based base VBN cord-010119-t1x9gknd 4120 15 on on IN cord-010119-t1x9gknd 4120 16 clotting clotting NN cord-010119-t1x9gknd 4120 17 assay assay NN cord-010119-t1x9gknd 4120 18 ( ( -LRB- cord-010119-t1x9gknd 4120 19 STAV STAV NNP cord-010119-t1x9gknd 4120 20 R R NNP cord-010119-t1x9gknd 4120 21 -DEFICIENT -DEFICIENT . cord-010119-t1x9gknd 4121 1 92A 92A NNP cord-010119-t1x9gknd 4121 2 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 4121 3 2017 2017 CD cord-010119-t1x9gknd 4121 4 Vol Vol NNP cord-010119-t1x9gknd 4121 5 . . . cord-010119-t1x9gknd 4122 1 57 57 CD cord-010119-t1x9gknd 4123 1 Supplement supplement NN cord-010119-t1x9gknd 4123 2 S3 S3 NNP cord-010119-t1x9gknd 4123 3 VIII VIII NNP cord-010119-t1x9gknd 4123 4 Diagnostica Diagnostica NNP cord-010119-t1x9gknd 4123 5 Stago Stago NNP cord-010119-t1x9gknd 4123 6 ) ) -RRB- cord-010119-t1x9gknd 4123 7 . . . cord-010119-t1x9gknd 4124 1 FVIII FVIII NNS cord-010119-t1x9gknd 4124 2 levels level NNS cord-010119-t1x9gknd 4124 3 were be VBD cord-010119-t1x9gknd 4124 4 measured measure VBN cord-010119-t1x9gknd 4124 5 at at IN cord-010119-t1x9gknd 4124 6 five five CD cord-010119-t1x9gknd 4124 7 time time NN cord-010119-t1x9gknd 4124 8 points point NNS cord-010119-t1x9gknd 4124 9 : : : cord-010119-t1x9gknd 4124 10 prefreezing prefreezing NN cord-010119-t1x9gknd 4124 11 , , , cord-010119-t1x9gknd 4124 12 0 0 CD cord-010119-t1x9gknd 4124 13 , , , cord-010119-t1x9gknd 4124 14 24 24 CD cord-010119-t1x9gknd 4124 15 , , , cord-010119-t1x9gknd 4124 16 72 72 CD cord-010119-t1x9gknd 4124 17 and and CC cord-010119-t1x9gknd 4124 18 120 120 CD cord-010119-t1x9gknd 4124 19 hours hour NNS cord-010119-t1x9gknd 4124 20 post post NN cord-010119-t1x9gknd 4124 21 - - JJ cord-010119-t1x9gknd 4124 22 thawing thawing NN cord-010119-t1x9gknd 4124 23 . . . cord-010119-t1x9gknd 4125 1 FFP FFP NNP cord-010119-t1x9gknd 4125 2 were be VBD cord-010119-t1x9gknd 4125 3 thawed thaw VBN cord-010119-t1x9gknd 4125 4 using use VBG cord-010119-t1x9gknd 4125 5 Helmer Helmer NNP cord-010119-t1x9gknd 4125 6 Plasma Plasma NNP cord-010119-t1x9gknd 4125 7 Thawer Thawer NNP cord-010119-t1x9gknd 4125 8 ( ( -LRB- cord-010119-t1x9gknd 4125 9 Helmer Helmer NNP cord-010119-t1x9gknd 4125 10 Scientific Scientific NNP cord-010119-t1x9gknd 4125 11 ) ) -RRB- cord-010119-t1x9gknd 4125 12 at at IN cord-010119-t1x9gknd 4125 13 30 30 CD cord-010119-t1x9gknd 4125 14 to to IN cord-010119-t1x9gknd 4125 15 378C 378c CD cord-010119-t1x9gknd 4125 16 for for IN cord-010119-t1x9gknd 4125 17 35 35 CD cord-010119-t1x9gknd 4125 18 minutes minute NNS cord-010119-t1x9gknd 4125 19 . . . cord-010119-t1x9gknd 4126 1 An an DT cord-010119-t1x9gknd 4126 2 aliquot aliquot NN cord-010119-t1x9gknd 4126 3 of of IN cord-010119-t1x9gknd 4126 4 thawed thaw VBN cord-010119-t1x9gknd 4126 5 FFP FFP NNP cord-010119-t1x9gknd 4126 6 from from IN cord-010119-t1x9gknd 4126 7 each each DT cord-010119-t1x9gknd 4126 8 unit unit NN cord-010119-t1x9gknd 4126 9 was be VBD cord-010119-t1x9gknd 4126 10 removed remove VBN cord-010119-t1x9gknd 4126 11 and and CC cord-010119-t1x9gknd 4126 12 measured measure VBN cord-010119-t1x9gknd 4126 13 for for IN cord-010119-t1x9gknd 4126 14 FVIII FVIII NNP cord-010119-t1x9gknd 4126 15 before before IN cord-010119-t1x9gknd 4126 16 refrigeration refrigeration NN cord-010119-t1x9gknd 4126 17 ( ( -LRB- cord-010119-t1x9gknd 4126 18 0 0 CD cord-010119-t1x9gknd 4126 19 hours hour NNS cord-010119-t1x9gknd 4126 20 post post NN cord-010119-t1x9gknd 4126 21 - - JJ cord-010119-t1x9gknd 4126 22 thaw thaw VB cord-010119-t1x9gknd 4126 23 ) ) -RRB- cord-010119-t1x9gknd 4126 24 . . . cord-010119-t1x9gknd 4127 1 Thawed thawed JJ cord-010119-t1x9gknd 4127 2 plasma plasma NN cord-010119-t1x9gknd 4127 3 ( ( -LRB- cord-010119-t1x9gknd 4127 4 TP tp NN cord-010119-t1x9gknd 4127 5 ) ) -RRB- cord-010119-t1x9gknd 4127 6 units unit NNS cord-010119-t1x9gknd 4127 7 were be VBD cord-010119-t1x9gknd 4127 8 kept keep VBN cord-010119-t1x9gknd 4127 9 in in IN cord-010119-t1x9gknd 4127 10 a a DT cord-010119-t1x9gknd 4127 11 refrigerator refrigerator NN cord-010119-t1x9gknd 4127 12 at at IN cord-010119-t1x9gknd 4127 13 1 1 CD cord-010119-t1x9gknd 4127 14 to to IN cord-010119-t1x9gknd 4127 15 68C 68c NN cord-010119-t1x9gknd 4127 16 for for IN cord-010119-t1x9gknd 4127 17 5 5 CD cord-010119-t1x9gknd 4127 18 days day NNS cord-010119-t1x9gknd 4127 19 for for IN cord-010119-t1x9gknd 4127 20 subsequent subsequent JJ cord-010119-t1x9gknd 4127 21 testing testing NN cord-010119-t1x9gknd 4127 22 . . . cord-010119-t1x9gknd 4128 1 Results/ Results/ . cord-010119-t1x9gknd 4129 1 Finding finding NN cord-010119-t1x9gknd 4129 2 : : : cord-010119-t1x9gknd 4129 3 Results result NNS cord-010119-t1x9gknd 4129 4 obtained obtain VBN cord-010119-t1x9gknd 4129 5 were be VBD cord-010119-t1x9gknd 4129 6 listed list VBN cord-010119-t1x9gknd 4129 7 in in IN cord-010119-t1x9gknd 4129 8 Table Table NNP cord-010119-t1x9gknd 4129 9 1 1 CD cord-010119-t1x9gknd 4129 10 . . . cord-010119-t1x9gknd 4130 1 Units unit NNS cord-010119-t1x9gknd 4130 2 7 7 CD cord-010119-t1x9gknd 4130 3 to to TO cord-010119-t1x9gknd 4130 4 9 9 CD cord-010119-t1x9gknd 4130 5 were be VBD cord-010119-t1x9gknd 4130 6 not not RB cord-010119-t1x9gknd 4130 7 tested test VBN cord-010119-t1x9gknd 4130 8 for for IN cord-010119-t1x9gknd 4130 9 FVIII FVIII NNP cord-010119-t1x9gknd 4130 10 at at IN cord-010119-t1x9gknd 4130 11 post post NN cord-010119-t1x9gknd 4130 12 thaw-24 thaw-24 CD cord-010119-t1x9gknd 4130 13 hour hour NN cord-010119-t1x9gknd 4130 14 due due IN cord-010119-t1x9gknd 4130 15 to to IN cord-010119-t1x9gknd 4130 16 operational operational JJ cord-010119-t1x9gknd 4130 17 issues issue NNS cord-010119-t1x9gknd 4130 18 . . . cord-010119-t1x9gknd 4131 1 The the DT cord-010119-t1x9gknd 4131 2 overall overall JJ cord-010119-t1x9gknd 4131 3 FVIII FVIII NNP cord-010119-t1x9gknd 4131 4 concentration concentration NN cord-010119-t1x9gknd 4131 5 decreased decrease VBD cord-010119-t1x9gknd 4131 6 at at IN cord-010119-t1x9gknd 4131 7 an an DT cord-010119-t1x9gknd 4131 8 average average NN cord-010119-t1x9gknd 4131 9 of of IN cord-010119-t1x9gknd 4131 10 13 13 CD cord-010119-t1x9gknd 4131 11 % % NN cord-010119-t1x9gknd 4131 12 from from IN cord-010119-t1x9gknd 4131 13 pre pre JJ cord-010119-t1x9gknd 4131 14 - - JJ cord-010119-t1x9gknd 4131 15 freezing freezing JJ cord-010119-t1x9gknd 4131 16 to to IN cord-010119-t1x9gknd 4131 17 post post VB cord-010119-t1x9gknd 4131 18 thaw thaw VB cord-010119-t1x9gknd 4131 19 0 0 CD cord-010119-t1x9gknd 4131 20 hour hour NN cord-010119-t1x9gknd 4131 21 . . . cord-010119-t1x9gknd 4132 1 After after IN cord-010119-t1x9gknd 4132 2 further further JJ cord-010119-t1x9gknd 4132 3 storage storage NN cord-010119-t1x9gknd 4132 4 of of IN cord-010119-t1x9gknd 4132 5 TP TP NNP cord-010119-t1x9gknd 4132 6 post post NN cord-010119-t1x9gknd 4132 7 thaw-24 thaw-24 CC cord-010119-t1x9gknd 4132 8 hour hour NN cord-010119-t1x9gknd 4132 9 and and CC cord-010119-t1x9gknd 4132 10 -72 -72 CD cord-010119-t1x9gknd 4132 11 hour hour NN cord-010119-t1x9gknd 4132 12 , , , cord-010119-t1x9gknd 4132 13 residual residual JJ cord-010119-t1x9gknd 4132 14 FVIII FVIII NNP cord-010119-t1x9gknd 4132 15 level level NN cord-010119-t1x9gknd 4132 16 remain remain VBP cord-010119-t1x9gknd 4132 17 to to TO cord-010119-t1x9gknd 4132 18 be be VB cord-010119-t1x9gknd 4132 19 above above IN cord-010119-t1x9gknd 4132 20 50 50 CD cord-010119-t1x9gknd 4132 21 IU IU NNP cord-010119-t1x9gknd 4132 22 / / SYM cord-010119-t1x9gknd 4132 23 dL dl NN cord-010119-t1x9gknd 4132 24 except except IN cord-010119-t1x9gknd 4132 25 unit unit NN cord-010119-t1x9gknd 4132 26 10 10 CD cord-010119-t1x9gknd 4132 27 which which WDT cord-010119-t1x9gknd 4132 28 had have VBD cord-010119-t1x9gknd 4132 29 a a DT cord-010119-t1x9gknd 4132 30 lower low JJR cord-010119-t1x9gknd 4132 31 initial initial JJ cord-010119-t1x9gknd 4132 32 FVIII FVIII NNP cord-010119-t1x9gknd 4132 33 concentration concentration NN cord-010119-t1x9gknd 4132 34 . . . cord-010119-t1x9gknd 4133 1 At at IN cord-010119-t1x9gknd 4133 2 post post NN cord-010119-t1x9gknd 4133 3 thaw-120 thaw-120 DT cord-010119-t1x9gknd 4133 4 hour hour NN cord-010119-t1x9gknd 4133 5 , , , cord-010119-t1x9gknd 4133 6 7 7 CD cord-010119-t1x9gknd 4133 7 out out IN cord-010119-t1x9gknd 4133 8 of of IN cord-010119-t1x9gknd 4133 9 10 10 CD cord-010119-t1x9gknd 4133 10 units unit NNS cord-010119-t1x9gknd 4133 11 tested test VBN cord-010119-t1x9gknd 4133 12 had have VBD cord-010119-t1x9gknd 4133 13 residual residual JJ cord-010119-t1x9gknd 4133 14 FVIII FVIII NNP cord-010119-t1x9gknd 4133 15 activity activity NN cord-010119-t1x9gknd 4133 16 within within IN cord-010119-t1x9gknd 4133 17 the the DT cord-010119-t1x9gknd 4133 18 pre pre JJ cord-010119-t1x9gknd 4133 19 - - JJ cord-010119-t1x9gknd 4133 20 set set JJ cord-010119-t1x9gknd 4133 21 standard standard NN cord-010119-t1x9gknd 4133 22 of of IN cord-010119-t1x9gknd 4133 23 50 50 CD cord-010119-t1x9gknd 4134 1 IU/ iu/ DT cord-010119-t1x9gknd 4135 1 dL. dL. NNP cord-010119-t1x9gknd 4136 1 The the DT cord-010119-t1x9gknd 4136 2 average average JJ cord-010119-t1x9gknd 4136 3 decline decline NN cord-010119-t1x9gknd 4136 4 from from IN cord-010119-t1x9gknd 4136 5 0-hour 0-hour CD cord-010119-t1x9gknd 4136 6 post post NN cord-010119-t1x9gknd 4136 7 - - NN cord-010119-t1x9gknd 4136 8 thaw thaw NN cord-010119-t1x9gknd 4136 9 to to IN cord-010119-t1x9gknd 4136 10 24-hour 24-hour CD cord-010119-t1x9gknd 4136 11 , , , cord-010119-t1x9gknd 4136 12 72-hour 72-hour CD cord-010119-t1x9gknd 4136 13 and and CC cord-010119-t1x9gknd 4136 14 120hour 120hour NNP cord-010119-t1x9gknd 4136 15 post post NN cord-010119-t1x9gknd 4136 16 - - NN cord-010119-t1x9gknd 4136 17 thaw thaw NN cord-010119-t1x9gknd 4136 18 was be VBD cord-010119-t1x9gknd 4136 19 36.5 36.5 CD cord-010119-t1x9gknd 4136 20 % % NN cord-010119-t1x9gknd 4136 21 , , , cord-010119-t1x9gknd 4136 22 42.7 42.7 CD cord-010119-t1x9gknd 4136 23 % % NN cord-010119-t1x9gknd 4136 24 and and CC cord-010119-t1x9gknd 4136 25 47.9 47.9 CD cord-010119-t1x9gknd 4136 26 % % NN cord-010119-t1x9gknd 4136 27 respectively respectively RB cord-010119-t1x9gknd 4136 28 . . . cord-010119-t1x9gknd 4137 1 There there EX cord-010119-t1x9gknd 4137 2 was be VBD cord-010119-t1x9gknd 4137 3 no no DT cord-010119-t1x9gknd 4137 4 observed observed JJ cord-010119-t1x9gknd 4137 5 trend trend NN cord-010119-t1x9gknd 4137 6 of of IN cord-010119-t1x9gknd 4137 7 any any DT cord-010119-t1x9gknd 4137 8 blood blood NN cord-010119-t1x9gknd 4137 9 group group NN cord-010119-t1x9gknd 4137 10 having have VBG cord-010119-t1x9gknd 4137 11 higher high JJR cord-010119-t1x9gknd 4137 12 or or CC cord-010119-t1x9gknd 4137 13 lower low JJR cord-010119-t1x9gknd 4137 14 pre pre JJ cord-010119-t1x9gknd 4137 15 - - JJ cord-010119-t1x9gknd 4137 16 freezing freezing JJ cord-010119-t1x9gknd 4137 17 FVIII FVIII NNP cord-010119-t1x9gknd 4137 18 and and CC cord-010119-t1x9gknd 4137 19 this this DT cord-010119-t1x9gknd 4137 20 is be VBZ cord-010119-t1x9gknd 4137 21 likely likely JJ cord-010119-t1x9gknd 4137 22 due due IN cord-010119-t1x9gknd 4137 23 to to IN cord-010119-t1x9gknd 4137 24 small small JJ cord-010119-t1x9gknd 4137 25 sample sample NN cord-010119-t1x9gknd 4137 26 size size NN cord-010119-t1x9gknd 4137 27 . . . cord-010119-t1x9gknd 4138 1 Conclusion conclusion NN cord-010119-t1x9gknd 4138 2 : : : cord-010119-t1x9gknd 4138 3 Decrease decrease NN cord-010119-t1x9gknd 4138 4 of of IN cord-010119-t1x9gknd 4138 5 coagulation coagulation NN cord-010119-t1x9gknd 4138 6 factor factor NN cord-010119-t1x9gknd 4138 7 such such JJ cord-010119-t1x9gknd 4138 8 as as IN cord-010119-t1x9gknd 4138 9 FVIII FVIII NNP cord-010119-t1x9gknd 4138 10 in in IN cord-010119-t1x9gknd 4138 11 FFP FFP NNP cord-010119-t1x9gknd 4138 12 is be VBZ cord-010119-t1x9gknd 4138 13 expected expect VBN cord-010119-t1x9gknd 4138 14 due due IN cord-010119-t1x9gknd 4138 15 to to IN cord-010119-t1x9gknd 4138 16 its -PRON- PRP$ cord-010119-t1x9gknd 4138 17 diminishing diminish VBG cord-010119-t1x9gknd 4138 18 stability stability NN cord-010119-t1x9gknd 4138 19 . . . cord-010119-t1x9gknd 4139 1 Nevertheless nevertheless RB cord-010119-t1x9gknd 4139 2 , , , cord-010119-t1x9gknd 4139 3 our -PRON- PRP$ cord-010119-t1x9gknd 4139 4 data datum NNS cord-010119-t1x9gknd 4139 5 showed show VBD cord-010119-t1x9gknd 4139 6 that that IN cord-010119-t1x9gknd 4139 7 majority majority NN cord-010119-t1x9gknd 4139 8 of of IN cord-010119-t1x9gknd 4139 9 the the DT cord-010119-t1x9gknd 4139 10 TP TP NNP cord-010119-t1x9gknd 4139 11 retained retain VBD cord-010119-t1x9gknd 4139 12 at at IN cord-010119-t1x9gknd 4139 13 least least JJS cord-010119-t1x9gknd 4139 14 50 50 CD cord-010119-t1x9gknd 4139 15 IU IU NNP cord-010119-t1x9gknd 4139 16 / / SYM cord-010119-t1x9gknd 4139 17 dL dl NN cord-010119-t1x9gknd 4139 18 of of IN cord-010119-t1x9gknd 4139 19 FVIII FVIII NNP cord-010119-t1x9gknd 4139 20 . . . cord-010119-t1x9gknd 4140 1 Typically typically RB cord-010119-t1x9gknd 4140 2 patients patient NNS cord-010119-t1x9gknd 4140 3 with with IN cord-010119-t1x9gknd 4140 4 factor factor NN cord-010119-t1x9gknd 4140 5 levels level NNS cord-010119-t1x9gknd 4140 6 below below IN cord-010119-t1x9gknd 4140 7 30 30 CD cord-010119-t1x9gknd 4140 8 IU IU NNP cord-010119-t1x9gknd 4140 9 / / SYM cord-010119-t1x9gknd 4140 10 dL dl NN cord-010119-t1x9gknd 4140 11 may may MD cord-010119-t1x9gknd 4140 12 start start VB cord-010119-t1x9gknd 4140 13 to to TO cord-010119-t1x9gknd 4140 14 show show VB cord-010119-t1x9gknd 4140 15 abnormal abnormal JJ cord-010119-t1x9gknd 4140 16 coagulation coagulation NN cord-010119-t1x9gknd 4140 17 profile profile NN cord-010119-t1x9gknd 4140 18 . . . cord-010119-t1x9gknd 4141 1 While while IN cord-010119-t1x9gknd 4141 2 TP TP NNP cord-010119-t1x9gknd 4141 3 is be VBZ cord-010119-t1x9gknd 4141 4 not not RB cord-010119-t1x9gknd 4141 5 used use VBN cord-010119-t1x9gknd 4141 6 for for IN cord-010119-t1x9gknd 4141 7 specific specific JJ cord-010119-t1x9gknd 4141 8 factor factor NN cord-010119-t1x9gknd 4141 9 replacement replacement NN cord-010119-t1x9gknd 4141 10 therapy therapy NN cord-010119-t1x9gknd 4141 11 , , , cord-010119-t1x9gknd 4141 12 it -PRON- PRP cord-010119-t1x9gknd 4141 13 may may MD cord-010119-t1x9gknd 4141 14 be be VB cord-010119-t1x9gknd 4141 15 indicated indicate VBN cord-010119-t1x9gknd 4141 16 for for IN cord-010119-t1x9gknd 4141 17 patients patient NNS cord-010119-t1x9gknd 4141 18 with with IN cord-010119-t1x9gknd 4141 19 general general JJ cord-010119-t1x9gknd 4141 20 coagulopathies coagulopathie NNS cord-010119-t1x9gknd 4141 21 and and CC cord-010119-t1x9gknd 4141 22 active active JJ cord-010119-t1x9gknd 4141 23 bleeding bleeding NN cord-010119-t1x9gknd 4141 24 . . . cord-010119-t1x9gknd 4142 1 Further further JJ cord-010119-t1x9gknd 4142 2 study study NN cord-010119-t1x9gknd 4142 3 extending extend VBG cord-010119-t1x9gknd 4142 4 to to IN cord-010119-t1x9gknd 4142 5 measurement measurement NN cord-010119-t1x9gknd 4142 6 of of IN cord-010119-t1x9gknd 4142 7 other other JJ cord-010119-t1x9gknd 4142 8 labile labile JJ cord-010119-t1x9gknd 4142 9 factor factor NN cord-010119-t1x9gknd 4142 10 such such JJ cord-010119-t1x9gknd 4142 11 as as IN cord-010119-t1x9gknd 4142 12 FV FV NNP cord-010119-t1x9gknd 4142 13 may may MD cord-010119-t1x9gknd 4142 14 add add VB cord-010119-t1x9gknd 4142 15 value value NN cord-010119-t1x9gknd 4142 16 to to IN cord-010119-t1x9gknd 4142 17 the the DT cord-010119-t1x9gknd 4142 18 validation validation NN cord-010119-t1x9gknd 4142 19 study study NN cord-010119-t1x9gknd 4142 20 . . . cord-010119-t1x9gknd 4143 1 Validation validation NN cord-010119-t1x9gknd 4143 2 of of IN cord-010119-t1x9gknd 4143 3 the the DT cord-010119-t1x9gknd 4143 4 Pathogen Pathogen NNP cord-010119-t1x9gknd 4143 5 Reduction Reduction NNP cord-010119-t1x9gknd 4143 6 Method Method NNP cord-010119-t1x9gknd 4143 7 Using use VBG cord-010119-t1x9gknd 4143 8 Amotosalen/ Amotosalen/ NNP cord-010119-t1x9gknd 4143 9 UVA UVA NNP cord-010119-t1x9gknd 4143 10 : : : cord-010119-t1x9gknd 4144 1 Comparing compare VBG cord-010119-t1x9gknd 4144 2 Pathogen Pathogen NNP cord-010119-t1x9gknd 4144 3 - - HYPH cord-010119-t1x9gknd 4144 4 Reduced reduce VBN cord-010119-t1x9gknd 4144 5 Pooled pool VBN cord-010119-t1x9gknd 4144 6 PRP prp NN cord-010119-t1x9gknd 4144 7 - - HYPH cord-010119-t1x9gknd 4144 8 Platelets platelet NNS cord-010119-t1x9gknd 4144 9 and and CC cord-010119-t1x9gknd 4144 10 Conventional conventional JJ cord-010119-t1x9gknd 4144 11 Single single JJ cord-010119-t1x9gknd 4144 12 PRP prp NN cord-010119-t1x9gknd 4144 13 Platelets Platelets NNPS cord-010119-t1x9gknd 4144 14 for for IN cord-010119-t1x9gknd 4144 15 Quality Quality NNP cord-010119-t1x9gknd 4144 16 and and CC cord-010119-t1x9gknd 4144 17 Bacterial Bacterial NNP cord-010119-t1x9gknd 4144 18 Inactivation Inactivation NNP cord-010119-t1x9gknd 4144 19 Efficacy Efficacy NNP cord-010119-t1x9gknd 4144 20 Lubna Lubna NNP cord-010119-t1x9gknd 4144 21 Ahmed Ahmed NNP cord-010119-t1x9gknd 4144 22 Almenawi Almenawi NNP cord-010119-t1x9gknd 4144 23 1 1 CD cord-010119-t1x9gknd 4144 24 , , , cord-010119-t1x9gknd 4144 25 Ayman Ayman NNP cord-010119-t1x9gknd 4144 26 Mohamad Mohamad NNP cord-010119-t1x9gknd 4144 27 Sabri Sabri NNP cord-010119-t1x9gknd 4144 28 1 1 CD cord-010119-t1x9gknd 4144 29 , , , cord-010119-t1x9gknd 4144 30 Ali Ali NNP cord-010119-t1x9gknd 4144 31 Abdullah Abdullah NNP cord-010119-t1x9gknd 4144 32 Alajeafi Alajeafi NNP cord-010119-t1x9gknd 4144 33 1 1 CD cord-010119-t1x9gknd 4144 34 , , , cord-010119-t1x9gknd 4144 35 Ashwaq Ashwaq NNP cord-010119-t1x9gknd 4144 36 Hasan Hasan NNP cord-010119-t1x9gknd 4144 37 Alhekri Alhekri NNP cord-010119-t1x9gknd 4144 38 1 1 CD cord-010119-t1x9gknd 4144 39 , , , cord-010119-t1x9gknd 4144 40 Saleem Saleem NNP cord-010119-t1x9gknd 4144 41 Bin Bin NNP cord-010119-t1x9gknd 4144 42 Mahfouz Mahfouz NNP cord-010119-t1x9gknd 4144 43 1 1 CD cord-010119-t1x9gknd 4144 44 , , , cord-010119-t1x9gknd 4144 45 Ali Ali NNP cord-010119-t1x9gknd 4144 46 Hasan Hasan NNP cord-010119-t1x9gknd 4144 47 Alkhodari Alkhodari NNP cord-010119-t1x9gknd 4144 48 1 1 CD cord-010119-t1x9gknd 4144 49 , , , cord-010119-t1x9gknd 4144 50 Rawya Rawya NNP cord-010119-t1x9gknd 4144 51 Saeed Saeed NNP cord-010119-t1x9gknd 4144 52 Shealy Shealy NNP cord-010119-t1x9gknd 4144 53 1 1 CD cord-010119-t1x9gknd 4144 54 , , , cord-010119-t1x9gknd 4144 55 Marcus Marcus NNP cord-010119-t1x9gknd 4144 56 Picard Picard NNP cord-010119-t1x9gknd 4144 57 - - HYPH cord-010119-t1x9gknd 4144 58 Maureau Maureau NNP cord-010119-t1x9gknd 4145 1 * * NFP cord-010119-t1x9gknd 4145 2 2 2 CD cord-010119-t1x9gknd 4145 3 and and CC cord-010119-t1x9gknd 4145 4 Hussain Hussain NNP cord-010119-t1x9gknd 4145 5 Bana Bana NNP cord-010119-t1x9gknd 4145 6 Almalki Almalki NNP cord-010119-t1x9gknd 4145 7 1 1 CD cord-010119-t1x9gknd 4145 8 . . . cord-010119-t1x9gknd 4145 9 1 1 CD cord-010119-t1x9gknd 4145 10 King King NNP cord-010119-t1x9gknd 4145 11 Abdulaziz Abdulaziz NNP cord-010119-t1x9gknd 4145 12 Hospital Hospital NNP cord-010119-t1x9gknd 4145 13 and and CC cord-010119-t1x9gknd 4145 14 Oncology Oncology NNP cord-010119-t1x9gknd 4145 15 Center Center NNP cord-010119-t1x9gknd 4145 16 , , , cord-010119-t1x9gknd 4145 17 2 2 CD cord-010119-t1x9gknd 4145 18 Cerus Cerus NNP cord-010119-t1x9gknd 4145 19 Europe Europe NNP cord-010119-t1x9gknd 4145 20 BV BV NNP cord-010119-t1x9gknd 4145 21 Background Background NNP cord-010119-t1x9gknd 4145 22 / / SYM cord-010119-t1x9gknd 4145 23 Case Case NNP cord-010119-t1x9gknd 4145 24 Studies Studies NNPS cord-010119-t1x9gknd 4145 25 : : : cord-010119-t1x9gknd 4146 1 The the DT cord-010119-t1x9gknd 4146 2 growing grow VBG cord-010119-t1x9gknd 4146 3 number number NN cord-010119-t1x9gknd 4146 4 of of IN cord-010119-t1x9gknd 4146 5 transfusiontransmitted transfusiontransmitte VBN cord-010119-t1x9gknd 4146 6 infectious infectious JJ cord-010119-t1x9gknd 4146 7 ( ( -LRB- cord-010119-t1x9gknd 4146 8 TTI TTI NNP cord-010119-t1x9gknd 4146 9 ) ) -RRB- cord-010119-t1x9gknd 4146 10 risks risk NNS cord-010119-t1x9gknd 4146 11 , , , cord-010119-t1x9gknd 4146 12 including include VBG cord-010119-t1x9gknd 4146 13 emerging emerge VBG cord-010119-t1x9gknd 4146 14 and and CC cord-010119-t1x9gknd 4146 15 endemic endemic JJ cord-010119-t1x9gknd 4146 16 pathogens pathogen NNS cord-010119-t1x9gknd 4146 17 , , , cord-010119-t1x9gknd 4146 18 is be VBZ cord-010119-t1x9gknd 4146 19 a a DT cord-010119-t1x9gknd 4146 20 constant constant JJ cord-010119-t1x9gknd 4146 21 challenge challenge NN cord-010119-t1x9gknd 4146 22 for for IN cord-010119-t1x9gknd 4146 23 blood blood NN cord-010119-t1x9gknd 4146 24 centers center NNS cord-010119-t1x9gknd 4146 25 in in IN cord-010119-t1x9gknd 4146 26 Saudi Saudi NNP cord-010119-t1x9gknd 4146 27 Arabia Arabia NNP cord-010119-t1x9gknd 4146 28 . . . cord-010119-t1x9gknd 4147 1 While while IN cord-010119-t1x9gknd 4147 2 for for IN cord-010119-t1x9gknd 4147 3 a a DT cord-010119-t1x9gknd 4147 4 limited limited JJ cord-010119-t1x9gknd 4147 5 number number NN cord-010119-t1x9gknd 4147 6 of of IN cord-010119-t1x9gknd 4147 7 these these DT cord-010119-t1x9gknd 4147 8 pathogens pathogen NNS cord-010119-t1x9gknd 4147 9 TTI TTI NNP cord-010119-t1x9gknd 4147 10 risk risk NN cord-010119-t1x9gknd 4147 11 can can MD cord-010119-t1x9gknd 4147 12 be be VB cord-010119-t1x9gknd 4147 13 reduced reduce VBN cord-010119-t1x9gknd 4147 14 using use VBG cord-010119-t1x9gknd 4147 15 blood blood NN cord-010119-t1x9gknd 4147 16 screening screening NN cord-010119-t1x9gknd 4147 17 assays assay NNS cord-010119-t1x9gknd 4147 18 , , , cord-010119-t1x9gknd 4147 19 alternative alternative JJ cord-010119-t1x9gknd 4147 20 solutions solution NNS cord-010119-t1x9gknd 4147 21 are be VBP cord-010119-t1x9gknd 4147 22 anticipated anticipate VBN cord-010119-t1x9gknd 4147 23 . . . cord-010119-t1x9gknd 4148 1 Pathogen pathogen NN cord-010119-t1x9gknd 4148 2 reduction reduction NN cord-010119-t1x9gknd 4148 3 ( ( -LRB- cord-010119-t1x9gknd 4148 4 PR pr NN cord-010119-t1x9gknd 4148 5 ) ) -RRB- cord-010119-t1x9gknd 4148 6 technology technology NN cord-010119-t1x9gknd 4148 7 was be VBD cord-010119-t1x9gknd 4148 8 identified identify VBN cord-010119-t1x9gknd 4148 9 as as IN cord-010119-t1x9gknd 4148 10 a a DT cord-010119-t1x9gknd 4148 11 potential potential JJ cord-010119-t1x9gknd 4148 12 solution solution NN cord-010119-t1x9gknd 4148 13 . . . cord-010119-t1x9gknd 4149 1 Validation validation NN cord-010119-t1x9gknd 4149 2 of of IN cord-010119-t1x9gknd 4149 3 amotosalen amotosalen NNP cord-010119-t1x9gknd 4149 4 / / SYM cord-010119-t1x9gknd 4149 5 UVA UVA NNP cord-010119-t1x9gknd 4149 6 photochemical photochemical JJ cord-010119-t1x9gknd 4149 7 treatment treatment NN cord-010119-t1x9gknd 4149 8 in in IN cord-010119-t1x9gknd 4149 9 our -PRON- PRP$ cord-010119-t1x9gknd 4149 10 blood blood NN cord-010119-t1x9gknd 4149 11 center center NN cord-010119-t1x9gknd 4149 12 was be VBD cord-010119-t1x9gknd 4149 13 performed perform VBN cord-010119-t1x9gknd 4149 14 by by IN cord-010119-t1x9gknd 4149 15 comparing compare VBG cord-010119-t1x9gknd 4149 16 the the DT cord-010119-t1x9gknd 4149 17 platelet platelet NN cord-010119-t1x9gknd 4149 18 component component NN cord-010119-t1x9gknd 4149 19 ( ( -LRB- cord-010119-t1x9gknd 4149 20 PC pc NN cord-010119-t1x9gknd 4149 21 ) ) -RRB- cord-010119-t1x9gknd 4149 22 quality quality NN cord-010119-t1x9gknd 4149 23 of of IN cord-010119-t1x9gknd 4149 24 the the DT cord-010119-t1x9gknd 4149 25 standard standard JJ cord-010119-t1x9gknd 4149 26 " " `` cord-010119-t1x9gknd 4149 27 control control NN cord-010119-t1x9gknd 4149 28 " " '' cord-010119-t1x9gknd 4149 29 single single JJ cord-010119-t1x9gknd 4149 30 - - HYPH cord-010119-t1x9gknd 4149 31 donor donor NN cord-010119-t1x9gknd 4149 32 PRP prp NN cord-010119-t1x9gknd 4149 33 - - HYPH cord-010119-t1x9gknd 4149 34 concentrate concentrate NN cord-010119-t1x9gknd 4149 35 in in IN cord-010119-t1x9gknd 4149 36 100 100 CD cord-010119-t1x9gknd 4149 37 % % NN cord-010119-t1x9gknd 4149 38 plasma plasma NN cord-010119-t1x9gknd 4149 39 over over IN cord-010119-t1x9gknd 4149 40 a a DT cord-010119-t1x9gknd 4149 41 5 5 CD cord-010119-t1x9gknd 4149 42 day day NN cord-010119-t1x9gknd 4149 43 storage storage NN cord-010119-t1x9gknd 4149 44 period period NN cord-010119-t1x9gknd 4149 45 and and CC cord-010119-t1x9gknd 4149 46 the the DT cord-010119-t1x9gknd 4149 47 new new JJ cord-010119-t1x9gknd 4149 48 " " `` cord-010119-t1x9gknd 4149 49 test test NN cord-010119-t1x9gknd 4149 50 " " '' cord-010119-t1x9gknd 4149 51 pathogen pathogen NN cord-010119-t1x9gknd 4149 52 - - HYPH cord-010119-t1x9gknd 4149 53 reduced reduce VBN cord-010119-t1x9gknd 4149 54 , , , cord-010119-t1x9gknd 4149 55 pooled pool VBN cord-010119-t1x9gknd 4149 56 ( ( -LRB- cord-010119-t1x9gknd 4149 57 pools pool NNS cord-010119-t1x9gknd 4149 58 of of IN cord-010119-t1x9gknd 4149 59 5 5 CD cord-010119-t1x9gknd 4149 60 ) ) -RRB- cord-010119-t1x9gknd 4150 1 PRP PRP NNP cord-010119-t1x9gknd 4150 2 PC PC NNP cord-010119-t1x9gknd 4150 3 in in IN cord-010119-t1x9gknd 4150 4 100 100 CD cord-010119-t1x9gknd 4150 5 % % NN cord-010119-t1x9gknd 4150 6 plasma plasma NN cord-010119-t1x9gknd 4150 7 over over IN cord-010119-t1x9gknd 4150 8 a a DT cord-010119-t1x9gknd 4150 9 7 7 CD cord-010119-t1x9gknd 4150 10 day day NN cord-010119-t1x9gknd 4150 11 storage storage NN cord-010119-t1x9gknd 4150 12 period period NN cord-010119-t1x9gknd 4150 13 . . . cord-010119-t1x9gknd 4151 1 The the DT cord-010119-t1x9gknd 4151 2 efficacy efficacy NN cord-010119-t1x9gknd 4151 3 of of IN cord-010119-t1x9gknd 4151 4 the the DT cord-010119-t1x9gknd 4151 5 bacterial bacterial JJ cord-010119-t1x9gknd 4151 6 inactivation inactivation NN cord-010119-t1x9gknd 4151 7 was be VBD cord-010119-t1x9gknd 4151 8 also also RB cord-010119-t1x9gknd 4151 9 assessed assess VBN cord-010119-t1x9gknd 4151 10 in in IN cord-010119-t1x9gknd 4151 11 our -PRON- PRP$ cord-010119-t1x9gknd 4151 12 setting setting NN cord-010119-t1x9gknd 4151 13 . . . cord-010119-t1x9gknd 4152 1 Study Study NNP cord-010119-t1x9gknd 4152 2 Design Design NNP cord-010119-t1x9gknd 4152 3 / / SYM cord-010119-t1x9gknd 4152 4 Method method NN cord-010119-t1x9gknd 4152 5 : : : cord-010119-t1x9gknd 4153 1 The the DT cord-010119-t1x9gknd 4153 2 quality quality NN cord-010119-t1x9gknd 4153 3 parameters parameter NNS cord-010119-t1x9gknd 4153 4 of of IN cord-010119-t1x9gknd 4153 5 4 4 CD cord-010119-t1x9gknd 4153 6 leucoreduced leucoreduced JJ cord-010119-t1x9gknd 4153 7 test test NN cord-010119-t1x9gknd 4153 8 PCs pc NNS cord-010119-t1x9gknd 4153 9 were be VBD cord-010119-t1x9gknd 4153 10 assessed assess VBN cord-010119-t1x9gknd 4153 11 at at IN cord-010119-t1x9gknd 4153 12 day day NN cord-010119-t1x9gknd 4153 13 7 7 CD cord-010119-t1x9gknd 4153 14 of of IN cord-010119-t1x9gknd 4153 15 storage storage NN cord-010119-t1x9gknd 4153 16 and and CC cord-010119-t1x9gknd 4153 17 compared compare VBN cord-010119-t1x9gknd 4153 18 to to IN cord-010119-t1x9gknd 4153 19 leucoreduced leucoreduced JJ cord-010119-t1x9gknd 4153 20 control control NN cord-010119-t1x9gknd 4153 21 PC PC NNP cord-010119-t1x9gknd 4153 22 at at IN cord-010119-t1x9gknd 4153 23 day day NN cord-010119-t1x9gknd 4153 24 5 5 CD cord-010119-t1x9gknd 4153 25 of of IN cord-010119-t1x9gknd 4153 26 storage storage NN cord-010119-t1x9gknd 4153 27 . . . cord-010119-t1x9gknd 4154 1 The the DT cord-010119-t1x9gknd 4154 2 test test NN cord-010119-t1x9gknd 4154 3 PCs pc NNS cord-010119-t1x9gknd 4154 4 were be VBD cord-010119-t1x9gknd 4154 5 pathogen pathogen NN cord-010119-t1x9gknd 4154 6 - - HYPH cord-010119-t1x9gknd 4154 7 reduced reduce VBN cord-010119-t1x9gknd 4154 8 with with IN cord-010119-t1x9gknd 4154 9 the the DT cord-010119-t1x9gknd 4154 10 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 4154 11 Blood blood NN cord-010119-t1x9gknd 4154 12 System System NNP cord-010119-t1x9gknd 4154 13 ( ( -LRB- cord-010119-t1x9gknd 4154 14 Cerus Cerus NNP cord-010119-t1x9gknd 4154 15 Corporation Corporation NNP cord-010119-t1x9gknd 4154 16 , , , cord-010119-t1x9gknd 4154 17 Concord Concord NNP cord-010119-t1x9gknd 4154 18 , , , cord-010119-t1x9gknd 4154 19 U.S.A. U.S.A. NNP cord-010119-t1x9gknd 4154 20 ) ) -RRB- cord-010119-t1x9gknd 4154 21 at at IN cord-010119-t1x9gknd 4154 22 day day NN cord-010119-t1x9gknd 4154 23 0 0 CD cord-010119-t1x9gknd 4154 24 ; ; : cord-010119-t1x9gknd 4154 25 the the DT cord-010119-t1x9gknd 4154 26 process process NN cord-010119-t1x9gknd 4154 27 was be VBD cord-010119-t1x9gknd 4154 28 completed complete VBN cord-010119-t1x9gknd 4154 29 by by IN cord-010119-t1x9gknd 4154 30 day day NN cord-010119-t1x9gknd 4154 31 1 1 CD cord-010119-t1x9gknd 4154 32 post post NN cord-010119-t1x9gknd 4154 33 - - NN cord-010119-t1x9gknd 4154 34 collection collection NN cord-010119-t1x9gknd 4154 35 . . . cord-010119-t1x9gknd 4155 1 Samples sample NNS cord-010119-t1x9gknd 4155 2 were be VBD cord-010119-t1x9gknd 4155 3 taken take VBN cord-010119-t1x9gknd 4155 4 daily daily RB cord-010119-t1x9gknd 4155 5 for for IN cord-010119-t1x9gknd 4155 6 quality quality NN cord-010119-t1x9gknd 4155 7 analysis analysis NN cord-010119-t1x9gknd 4155 8 from from IN cord-010119-t1x9gknd 4155 9 test test NN cord-010119-t1x9gknd 4155 10 and and CC cord-010119-t1x9gknd 4155 11 control control NN cord-010119-t1x9gknd 4155 12 PC pc NN cord-010119-t1x9gknd 4155 13 until until IN cord-010119-t1x9gknd 4155 14 day day NN cord-010119-t1x9gknd 4155 15 5 5 CD cord-010119-t1x9gknd 4155 16 and and CC cord-010119-t1x9gknd 4155 17 day day NN cord-010119-t1x9gknd 4155 18 7 7 CD cord-010119-t1x9gknd 4155 19 , , , cord-010119-t1x9gknd 4155 20 respectively respectively RB cord-010119-t1x9gknd 4155 21 . . . cord-010119-t1x9gknd 4156 1 For for IN cord-010119-t1x9gknd 4156 2 bacterial bacterial JJ cord-010119-t1x9gknd 4156 3 spiking spiking NN cord-010119-t1x9gknd 4156 4 , , , cord-010119-t1x9gknd 4156 5 additional additional JJ cord-010119-t1x9gknd 4156 6 PC pc NN cord-010119-t1x9gknd 4156 7 were be VBD cord-010119-t1x9gknd 4156 8 spiked spike VBN cord-010119-t1x9gknd 4156 9 with with IN cord-010119-t1x9gknd 4156 10 each each DT cord-010119-t1x9gknd 4156 11 receiving receive VBG cord-010119-t1x9gknd 4156 12 4 4 CD cord-010119-t1x9gknd 4156 13 mL ml NN cord-010119-t1x9gknd 4156 14 of of IN cord-010119-t1x9gknd 4156 15 1 1 CD cord-010119-t1x9gknd 4156 16 McFarland McFarland NNP cord-010119-t1x9gknd 4156 17 ( ( -LRB- cord-010119-t1x9gknd 4156 18 $ $ $ cord-010119-t1x9gknd 4156 19 1.2x10 1.2x10 CD cord-010119-t1x9gknd 4156 20 9 9 CD cord-010119-t1x9gknd 4156 21 CFU CFU NNP cord-010119-t1x9gknd 4156 22 ) ) -RRB- cord-010119-t1x9gknd 4156 23 S. S. NNP cord-010119-t1x9gknd 4156 24 aureus aureus NN cord-010119-t1x9gknd 4156 25 , , , cord-010119-t1x9gknd 4156 26 S. S. NNP cord-010119-t1x9gknd 4156 27 epidermidis epidermidi NNS cord-010119-t1x9gknd 4156 28 , , , cord-010119-t1x9gknd 4156 29 E. E. NNP cord-010119-t1x9gknd 4156 30 coli coli NNS cord-010119-t1x9gknd 4156 31 , , , cord-010119-t1x9gknd 4156 32 P. P. NNP cord-010119-t1x9gknd 4156 33 aeruginosa aeruginosa NN cord-010119-t1x9gknd 4156 34 or or CC cord-010119-t1x9gknd 4156 35 S. S. NNP cord-010119-t1x9gknd 4156 36 viridans viridans NNP cord-010119-t1x9gknd 4156 37 , , , cord-010119-t1x9gknd 4156 38 respectively respectively RB cord-010119-t1x9gknd 4156 39 , , , cord-010119-t1x9gknd 4156 40 to to TO cord-010119-t1x9gknd 4156 41 challenge challenge VB cord-010119-t1x9gknd 4156 42 PR PR NNP cord-010119-t1x9gknd 4156 43 efficacy efficacy NN cord-010119-t1x9gknd 4156 44 . . . cord-010119-t1x9gknd 4157 1 Results/ Results/ . cord-010119-t1x9gknd 4158 1 Finding finding NN cord-010119-t1x9gknd 4158 2 : : : cord-010119-t1x9gknd 4159 1 The the DT cord-010119-t1x9gknd 4159 2 average average JJ cord-010119-t1x9gknd 4159 3 platelet platelet NN cord-010119-t1x9gknd 4159 4 loss loss NN cord-010119-t1x9gknd 4159 5 in in IN cord-010119-t1x9gknd 4159 6 the the DT cord-010119-t1x9gknd 4159 7 test test NN cord-010119-t1x9gknd 4159 8 PC pc NN cord-010119-t1x9gknd 4159 9 post post NN cord-010119-t1x9gknd 4159 10 PR pr NN cord-010119-t1x9gknd 4159 11 treatment treatment NN cord-010119-t1x9gknd 4159 12 was be VBD cord-010119-t1x9gknd 4159 13 4.7 4.7 CD cord-010119-t1x9gknd 4159 14 % % NN cord-010119-t1x9gknd 4159 15 6 6 CD cord-010119-t1x9gknd 4159 16 2.0 2.0 CD cord-010119-t1x9gknd 4159 17 , , , cord-010119-t1x9gknd 4159 18 the the DT cord-010119-t1x9gknd 4159 19 total total JJ cord-010119-t1x9gknd 4159 20 average average JJ cord-010119-t1x9gknd 4159 21 platelet platelet NN cord-010119-t1x9gknd 4159 22 loss loss NN cord-010119-t1x9gknd 4159 23 at at IN cord-010119-t1x9gknd 4159 24 day day NN cord-010119-t1x9gknd 4159 25 7 7 CD cord-010119-t1x9gknd 4159 26 was be VBD cord-010119-t1x9gknd 4159 27 11.2 11.2 CD cord-010119-t1x9gknd 4159 28 % % NN cord-010119-t1x9gknd 4159 29 62.8 62.8 CD cord-010119-t1x9gknd 4159 30 . . . cord-010119-t1x9gknd 4160 1 The the DT cord-010119-t1x9gknd 4160 2 average average JJ cord-010119-t1x9gknd 4160 3 platelet platelet NN cord-010119-t1x9gknd 4160 4 loss loss NN cord-010119-t1x9gknd 4160 5 in in IN cord-010119-t1x9gknd 4160 6 the the DT cord-010119-t1x9gknd 4160 7 control control NN cord-010119-t1x9gknd 4160 8 units unit NNS cord-010119-t1x9gknd 4160 9 at at IN cord-010119-t1x9gknd 4160 10 day day NN cord-010119-t1x9gknd 4160 11 5 5 CD cord-010119-t1x9gknd 4160 12 was be VBD cord-010119-t1x9gknd 4160 13 9.5 9.5 CD cord-010119-t1x9gknd 4160 14 % % NN cord-010119-t1x9gknd 4160 15 61.4 61.4 CD cord-010119-t1x9gknd 4160 16 . . . cord-010119-t1x9gknd 4161 1 The the DT cord-010119-t1x9gknd 4161 2 average average JJ cord-010119-t1x9gknd 4161 3 pH ph NN cord-010119-t1x9gknd 4161 4 of of IN cord-010119-t1x9gknd 4161 5 the the DT cord-010119-t1x9gknd 4161 6 test test NN cord-010119-t1x9gknd 4161 7 units unit NNS cord-010119-t1x9gknd 4161 8 at at IN cord-010119-t1x9gknd 4161 9 day day NN cord-010119-t1x9gknd 4161 10 7 7 CD cord-010119-t1x9gknd 4161 11 was be VBD cord-010119-t1x9gknd 4161 12 6.64 6.64 CD cord-010119-t1x9gknd 4161 13 60.04 60.04 CD cord-010119-t1x9gknd 4161 14 and and CC cord-010119-t1x9gknd 4161 15 in in IN cord-010119-t1x9gknd 4161 16 the the DT cord-010119-t1x9gknd 4161 17 same same JJ cord-010119-t1x9gknd 4161 18 range range NN cord-010119-t1x9gknd 4161 19 as as IN cord-010119-t1x9gknd 4161 20 the the DT cord-010119-t1x9gknd 4161 21 control control NN cord-010119-t1x9gknd 4161 22 PC pc NN cord-010119-t1x9gknd 4161 23 , , , cord-010119-t1x9gknd 4161 24 pH ph NN cord-010119-t1x9gknd 4161 25 5 5 CD cord-010119-t1x9gknd 4161 26 6.89 6.89 CD cord-010119-t1x9gknd 4161 27 60.09 60.09 CD cord-010119-t1x9gknd 4161 28 . . . cord-010119-t1x9gknd 4162 1 Glucose glucose NN cord-010119-t1x9gknd 4162 2 concentration concentration NN cord-010119-t1x9gknd 4162 3 in in IN cord-010119-t1x9gknd 4162 4 test test NN cord-010119-t1x9gknd 4162 5 PC pc NN cord-010119-t1x9gknd 4162 6 at at IN cord-010119-t1x9gknd 4162 7 day day NN cord-010119-t1x9gknd 4162 8 7 7 CD cord-010119-t1x9gknd 4162 9 ( ( -LRB- cord-010119-t1x9gknd 4162 10 13.8 13.8 CD cord-010119-t1x9gknd 4162 11 63.0 63.0 CD cord-010119-t1x9gknd 4162 12 mmol mmol NNP cord-010119-t1x9gknd 4162 13 / / SYM cord-010119-t1x9gknd 4162 14 L L NNP cord-010119-t1x9gknd 4162 15 ) ) -RRB- cord-010119-t1x9gknd 4162 16 was be VBD cord-010119-t1x9gknd 4162 17 lower low JJR cord-010119-t1x9gknd 4162 18 than than IN cord-010119-t1x9gknd 4162 19 in in IN cord-010119-t1x9gknd 4162 20 the the DT cord-010119-t1x9gknd 4162 21 day day NN cord-010119-t1x9gknd 4162 22 5 5 CD cord-010119-t1x9gknd 4162 23 control control NN cord-010119-t1x9gknd 4162 24 units unit NNS cord-010119-t1x9gknd 4162 25 ( ( -LRB- cord-010119-t1x9gknd 4162 26 18.32 18.32 CD cord-010119-t1x9gknd 4162 27 61.06 61.06 CD cord-010119-t1x9gknd 4162 28 mmol mmol NNP cord-010119-t1x9gknd 4162 29 / / SYM cord-010119-t1x9gknd 4162 30 L L NNP cord-010119-t1x9gknd 4162 31 ) ) -RRB- cord-010119-t1x9gknd 4162 32 . . . cord-010119-t1x9gknd 4163 1 Lactate lactate NN cord-010119-t1x9gknd 4163 2 levels level NNS cord-010119-t1x9gknd 4163 3 increased increase VBD cord-010119-t1x9gknd 4163 4 during during IN cord-010119-t1x9gknd 4163 5 the the DT cord-010119-t1x9gknd 4163 6 course course NN cord-010119-t1x9gknd 4163 7 of of IN cord-010119-t1x9gknd 4163 8 storage storage NN cord-010119-t1x9gknd 4163 9 ; ; : cord-010119-t1x9gknd 4163 10 lactate lactate NN cord-010119-t1x9gknd 4163 11 levels level NNS cord-010119-t1x9gknd 4163 12 at at IN cord-010119-t1x9gknd 4163 13 days day NNS cord-010119-t1x9gknd 4163 14 5 5 CD cord-010119-t1x9gknd 4163 15 and and CC cord-010119-t1x9gknd 4163 16 7 7 CD cord-010119-t1x9gknd 4163 17 were be VBD cord-010119-t1x9gknd 4163 18 outside outside IN cord-010119-t1x9gknd 4163 19 the the DT cord-010119-t1x9gknd 4163 20 range range NN cord-010119-t1x9gknd 4163 21 of of IN cord-010119-t1x9gknd 4163 22 the the DT cord-010119-t1x9gknd 4163 23 assay assay NN cord-010119-t1x9gknd 4163 24 ( ( -LRB- cord-010119-t1x9gknd 4163 25 > > NFP cord-010119-t1x9gknd 4163 26 15 15 CD cord-010119-t1x9gknd 4163 27 mmol mmol NNP cord-010119-t1x9gknd 4163 28 / / SYM cord-010119-t1x9gknd 4163 29 L L NNP cord-010119-t1x9gknd 4163 30 ) ) -RRB- cord-010119-t1x9gknd 4163 31 . . . cord-010119-t1x9gknd 4164 1 Cultures culture NNS cord-010119-t1x9gknd 4164 2 inoculated inoculate VBN cord-010119-t1x9gknd 4164 3 with with IN cord-010119-t1x9gknd 4164 4 pathogen pathogen NN cord-010119-t1x9gknd 4164 5 reduced reduce VBN cord-010119-t1x9gknd 4164 6 , , , cord-010119-t1x9gknd 4164 7 bacterially bacterially RB cord-010119-t1x9gknd 4164 8 spiked spiked JJ cord-010119-t1x9gknd 4164 9 units unit NNS cord-010119-t1x9gknd 4164 10 were be VBD cord-010119-t1x9gknd 4164 11 negative negative JJ cord-010119-t1x9gknd 4164 12 after after IN cord-010119-t1x9gknd 4164 13 7 7 CD cord-010119-t1x9gknd 4164 14 days day NNS cord-010119-t1x9gknd 4164 15 of of IN cord-010119-t1x9gknd 4164 16 incubation incubation NN cord-010119-t1x9gknd 4164 17 , , , cord-010119-t1x9gknd 4164 18 in in IN cord-010119-t1x9gknd 4164 19 contrast contrast NN cord-010119-t1x9gknd 4164 20 to to IN cord-010119-t1x9gknd 4164 21 those those DT cord-010119-t1x9gknd 4164 22 inoculated inoculate VBN cord-010119-t1x9gknd 4164 23 with with IN cord-010119-t1x9gknd 4164 24 nonpathogen nonpathogen NNP cord-010119-t1x9gknd 4164 25 reduced reduce VBN cord-010119-t1x9gknd 4164 26 samples sample NNS cord-010119-t1x9gknd 4164 27 from from IN cord-010119-t1x9gknd 4164 28 the the DT cord-010119-t1x9gknd 4164 29 control control NN cord-010119-t1x9gknd 4164 30 units unit NNS cord-010119-t1x9gknd 4164 31 , , , cord-010119-t1x9gknd 4164 32 which which WDT cord-010119-t1x9gknd 4164 33 were be VBD cord-010119-t1x9gknd 4164 34 positive positive JJ cord-010119-t1x9gknd 4164 35 for for IN cord-010119-t1x9gknd 4164 36 bacterial bacterial JJ cord-010119-t1x9gknd 4164 37 growth growth NN cord-010119-t1x9gknd 4164 38 . . . cord-010119-t1x9gknd 4165 1 Conclusion conclusion NN cord-010119-t1x9gknd 4165 2 : : : cord-010119-t1x9gknd 4166 1 The the DT cord-010119-t1x9gknd 4166 2 quality quality NN cord-010119-t1x9gknd 4166 3 parameters parameter NNS cord-010119-t1x9gknd 4166 4 of of IN cord-010119-t1x9gknd 4166 5 the the DT cord-010119-t1x9gknd 4166 6 pathogen pathogen NN cord-010119-t1x9gknd 4166 7 reduced reduce VBN cord-010119-t1x9gknd 4166 8 test test NN cord-010119-t1x9gknd 4166 9 PC pc NN cord-010119-t1x9gknd 4166 10 were be VBD cord-010119-t1x9gknd 4166 11 within within IN cord-010119-t1x9gknd 4166 12 specifications specification NNS cord-010119-t1x9gknd 4166 13 and and CC cord-010119-t1x9gknd 4166 14 comparable comparable JJ cord-010119-t1x9gknd 4166 15 to to IN cord-010119-t1x9gknd 4166 16 the the DT cord-010119-t1x9gknd 4166 17 conventional conventional JJ cord-010119-t1x9gknd 4166 18 control control NN cord-010119-t1x9gknd 4166 19 PC pc NN cord-010119-t1x9gknd 4166 20 . . . cord-010119-t1x9gknd 4167 1 The the DT cord-010119-t1x9gknd 4167 2 high high JJ cord-010119-t1x9gknd 4167 3 efficacy efficacy NN cord-010119-t1x9gknd 4167 4 of of IN cord-010119-t1x9gknd 4167 5 bacterial bacterial JJ cord-010119-t1x9gknd 4167 6 inactivation inactivation NN cord-010119-t1x9gknd 4167 7 together together RB cord-010119-t1x9gknd 4167 8 with with IN cord-010119-t1x9gknd 4167 9 comparable comparable JJ cord-010119-t1x9gknd 4167 10 quality quality NN cord-010119-t1x9gknd 4167 11 parameter parameter NN cord-010119-t1x9gknd 4167 12 values value NNS cord-010119-t1x9gknd 4167 13 suggests suggest VBZ cord-010119-t1x9gknd 4167 14 the the DT cord-010119-t1x9gknd 4167 15 use use NN cord-010119-t1x9gknd 4167 16 of of IN cord-010119-t1x9gknd 4167 17 amotosalen amotosalen NNP cord-010119-t1x9gknd 4167 18 / / SYM cord-010119-t1x9gknd 4167 19 UVA UVA NNP cord-010119-t1x9gknd 4167 20 pathogen pathogen NN cord-010119-t1x9gknd 4167 21 reduction reduction NN cord-010119-t1x9gknd 4167 22 is be VBZ cord-010119-t1x9gknd 4167 23 safe safe JJ cord-010119-t1x9gknd 4167 24 and and CC cord-010119-t1x9gknd 4167 25 efficient efficient JJ cord-010119-t1x9gknd 4167 26 to to TO cord-010119-t1x9gknd 4167 27 enhance enhance VB cord-010119-t1x9gknd 4167 28 PC pc NN cord-010119-t1x9gknd 4167 29 transfusion transfusion NN cord-010119-t1x9gknd 4167 30 safety safety NN cord-010119-t1x9gknd 4167 31 . . . cord-010119-t1x9gknd 4168 1 Keaton Keaton NNP cord-010119-t1x9gknd 4168 2 Charles Charles NNP cord-010119-t1x9gknd 4168 3 Stoner Stoner NNP cord-010119-t1x9gknd 4168 4 * * NFP cord-010119-t1x9gknd 4168 5 1 1 CD cord-010119-t1x9gknd 4168 6 , , , cord-010119-t1x9gknd 4168 7 Jay Jay NNP cord-010119-t1x9gknd 4168 8 Srinivasan Srinivasan NNP cord-010119-t1x9gknd 4168 9 2 2 CD cord-010119-t1x9gknd 4168 10 , , , cord-010119-t1x9gknd 4168 11 Jessica Jessica NNP cord-010119-t1x9gknd 4168 12 Poisson Poisson NNP cord-010119-t1x9gknd 4168 13 3 3 NNP cord-010119-t1x9gknd 4168 14 and and CC cord-010119-t1x9gknd 4168 15 Ian Ian NNP cord-010119-t1x9gknd 4168 16 Welsby Welsby NNP cord-010119-t1x9gknd 4169 1 4 4 LS cord-010119-t1x9gknd 4169 2 . . . cord-010119-t1x9gknd 4169 3 1 1 CD cord-010119-t1x9gknd 4169 4 Duke Duke NNP cord-010119-t1x9gknd 4169 5 University University NNP cord-010119-t1x9gknd 4169 6 , , , cord-010119-t1x9gknd 4169 7 2 2 CD cord-010119-t1x9gknd 4169 8 Duke Duke NNP cord-010119-t1x9gknd 4169 9 University University NNP cord-010119-t1x9gknd 4169 10 School School NNP cord-010119-t1x9gknd 4169 11 of of IN cord-010119-t1x9gknd 4169 12 Medicine Medicine NNP cord-010119-t1x9gknd 4169 13 , , , cord-010119-t1x9gknd 4169 14 3 3 CD cord-010119-t1x9gknd 4169 15 Duke Duke NNP cord-010119-t1x9gknd 4169 16 University University NNP cord-010119-t1x9gknd 4169 17 Hospital Hospital NNP cord-010119-t1x9gknd 4169 18 , , , cord-010119-t1x9gknd 4169 19 4 4 CD cord-010119-t1x9gknd 4169 20 Duke Duke NNP cord-010119-t1x9gknd 4169 21 University University NNP cord-010119-t1x9gknd 4169 22 Medical Medical NNP cord-010119-t1x9gknd 4169 23 Center Center NNP cord-010119-t1x9gknd 4169 24 Background Background NNP cord-010119-t1x9gknd 4169 25 / / SYM cord-010119-t1x9gknd 4169 26 Case Case NNP cord-010119-t1x9gknd 4169 27 Studies Studies NNPS cord-010119-t1x9gknd 4169 28 : : : cord-010119-t1x9gknd 4169 29 The the DT cord-010119-t1x9gknd 4169 30 coagulation coagulation NN cord-010119-t1x9gknd 4169 31 cascade cascade NN cord-010119-t1x9gknd 4169 32 relies rely VBZ cord-010119-t1x9gknd 4169 33 on on IN cord-010119-t1x9gknd 4169 34 a a DT cord-010119-t1x9gknd 4169 35 complex complex JJ cord-010119-t1x9gknd 4169 36 interaction interaction NN cord-010119-t1x9gknd 4169 37 between between IN cord-010119-t1x9gknd 4169 38 proteins protein NNS cord-010119-t1x9gknd 4169 39 known know VBN cord-010119-t1x9gknd 4169 40 as as IN cord-010119-t1x9gknd 4169 41 clotting clotting NN cord-010119-t1x9gknd 4169 42 factors factor NNS cord-010119-t1x9gknd 4169 43 . . . cord-010119-t1x9gknd 4170 1 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 4170 2 ( ( -LRB- cord-010119-t1x9gknd 4170 3 cryo cryo NN cord-010119-t1x9gknd 4170 4 ) ) -RRB- cord-010119-t1x9gknd 4170 5 is be VBZ cord-010119-t1x9gknd 4170 6 a a DT cord-010119-t1x9gknd 4170 7 plasma plasma NN cord-010119-t1x9gknd 4170 8 - - HYPH cord-010119-t1x9gknd 4170 9 derived derive VBN cord-010119-t1x9gknd 4170 10 blood blood NN cord-010119-t1x9gknd 4170 11 product product NN cord-010119-t1x9gknd 4170 12 that that WDT cord-010119-t1x9gknd 4170 13 contains contain VBZ cord-010119-t1x9gknd 4170 14 several several JJ cord-010119-t1x9gknd 4170 15 of of IN cord-010119-t1x9gknd 4170 16 the the DT cord-010119-t1x9gknd 4170 17 proteins protein NNS cord-010119-t1x9gknd 4170 18 central central JJ cord-010119-t1x9gknd 4170 19 to to IN cord-010119-t1x9gknd 4170 20 the the DT cord-010119-t1x9gknd 4170 21 clotting clotting NN cord-010119-t1x9gknd 4170 22 cascade cascade NN cord-010119-t1x9gknd 4170 23 and and CC cord-010119-t1x9gknd 4170 24 is be VBZ cord-010119-t1x9gknd 4170 25 typically typically RB cord-010119-t1x9gknd 4170 26 used use VBN cord-010119-t1x9gknd 4170 27 as as IN cord-010119-t1x9gknd 4170 28 a a DT cord-010119-t1x9gknd 4170 29 fibrinogen fibrinogen NN cord-010119-t1x9gknd 4170 30 replacement replacement NN cord-010119-t1x9gknd 4170 31 in in IN cord-010119-t1x9gknd 4170 32 bleeding bleed VBG cord-010119-t1x9gknd 4170 33 patients patient NNS cord-010119-t1x9gknd 4170 34 . . . cord-010119-t1x9gknd 4171 1 However however RB cord-010119-t1x9gknd 4171 2 , , , cord-010119-t1x9gknd 4171 3 cryo cryo NN cord-010119-t1x9gknd 4171 4 contents content NNS cord-010119-t1x9gknd 4171 5 tend tend VBP cord-010119-t1x9gknd 4171 6 to to TO cord-010119-t1x9gknd 4171 7 be be VB cord-010119-t1x9gknd 4171 8 variable variable JJ cord-010119-t1x9gknd 4171 9 , , , cord-010119-t1x9gknd 4171 10 and and CC cord-010119-t1x9gknd 4171 11 little little JJ cord-010119-t1x9gknd 4171 12 quantitative quantitative JJ cord-010119-t1x9gknd 4171 13 evidence evidence NN cord-010119-t1x9gknd 4171 14 exists exist VBZ cord-010119-t1x9gknd 4171 15 regarding regard VBG cord-010119-t1x9gknd 4171 16 the the DT cord-010119-t1x9gknd 4171 17 exact exact JJ cord-010119-t1x9gknd 4171 18 therapeutic therapeutic JJ cord-010119-t1x9gknd 4171 19 effect effect NN cord-010119-t1x9gknd 4171 20 of of IN cord-010119-t1x9gknd 4171 21 cryo cryo NN cord-010119-t1x9gknd 4171 22 on on IN cord-010119-t1x9gknd 4171 23 coagulation coagulation NN cord-010119-t1x9gknd 4171 24 . . . cord-010119-t1x9gknd 4172 1 My -PRON- PRP$ cord-010119-t1x9gknd 4172 2 study study NN cord-010119-t1x9gknd 4172 3 aimed aim VBD cord-010119-t1x9gknd 4172 4 to to TO cord-010119-t1x9gknd 4172 5 better better RB cord-010119-t1x9gknd 4172 6 characterize characterize VB cord-010119-t1x9gknd 4172 7 cryo cryo NN cord-010119-t1x9gknd 4172 8 for for IN cord-010119-t1x9gknd 4172 9 consistency consistency NN cord-010119-t1x9gknd 4172 10 across across IN cord-010119-t1x9gknd 4172 11 and and CC cord-010119-t1x9gknd 4172 12 within within IN cord-010119-t1x9gknd 4172 13 sources source NNS cord-010119-t1x9gknd 4172 14 in in IN cord-010119-t1x9gknd 4172 15 terms term NNS cord-010119-t1x9gknd 4172 16 of of IN cord-010119-t1x9gknd 4172 17 its -PRON- PRP$ cord-010119-t1x9gknd 4172 18 functional functional JJ cord-010119-t1x9gknd 4172 19 effect effect NN cord-010119-t1x9gknd 4172 20 on on IN cord-010119-t1x9gknd 4172 21 in in IN cord-010119-t1x9gknd 4172 22 vitroclot vitroclot NNP cord-010119-t1x9gknd 4172 23 formation formation NN cord-010119-t1x9gknd 4172 24 . . . cord-010119-t1x9gknd 4173 1 Study Study NNP cord-010119-t1x9gknd 4173 2 Design Design NNP cord-010119-t1x9gknd 4173 3 / / SYM cord-010119-t1x9gknd 4173 4 Method method NN cord-010119-t1x9gknd 4173 5 : : : cord-010119-t1x9gknd 4174 1 The the DT cord-010119-t1x9gknd 4174 2 Duke Duke NNP cord-010119-t1x9gknd 4174 3 Proteomics Proteomics NNP cord-010119-t1x9gknd 4174 4 Core Core NNP cord-010119-t1x9gknd 4174 5 conducted conduct VBD cord-010119-t1x9gknd 4174 6 a a DT cord-010119-t1x9gknd 4174 7 semiquantitative semiquantitative JJ cord-010119-t1x9gknd 4174 8 liquid liquid JJ cord-010119-t1x9gknd 4174 9 chromatography chromatography NN cord-010119-t1x9gknd 4174 10 - - HYPH cord-010119-t1x9gknd 4174 11 mass mass NN cord-010119-t1x9gknd 4174 12 spectrometry spectrometry NN cord-010119-t1x9gknd 4174 13 / / SYM cord-010119-t1x9gknd 4174 14 mass mass NN cord-010119-t1x9gknd 4174 15 spectrometry spectrometry NN cord-010119-t1x9gknd 4174 16 _SP cord-010119-t1x9gknd 4174 17 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 4174 18 developed develop VBD cord-010119-t1x9gknd 4174 19 an an DT cord-010119-t1x9gknd 4174 20 in in IN cord-010119-t1x9gknd 4174 21 vitromodel vitromodel NN cord-010119-t1x9gknd 4174 22 for for IN cord-010119-t1x9gknd 4174 23 a a DT cord-010119-t1x9gknd 4174 24 coagulopathic coagulopathic JJ cord-010119-t1x9gknd 4174 25 patient patient NN cord-010119-t1x9gknd 4174 26 using use VBG cord-010119-t1x9gknd 4174 27 serial serial JJ cord-010119-t1x9gknd 4174 28 dilutions dilution NNS cord-010119-t1x9gknd 4174 29 of of IN cord-010119-t1x9gknd 4174 30 pooled pool VBN cord-010119-t1x9gknd 4174 31 normal normal JJ cord-010119-t1x9gknd 4174 32 plasma plasma NN cord-010119-t1x9gknd 4174 33 with with IN cord-010119-t1x9gknd 4174 34 saline saline NN cord-010119-t1x9gknd 4174 35 and and CC cord-010119-t1x9gknd 4174 36 then then RB cord-010119-t1x9gknd 4174 37 added add VBD cord-010119-t1x9gknd 4174 38 the the DT cord-010119-t1x9gknd 4174 39 equivalent equivalent NN cord-010119-t1x9gknd 4174 40 of of IN cord-010119-t1x9gknd 4174 41 one one CD cord-010119-t1x9gknd 4174 42 , , , cord-010119-t1x9gknd 4174 43 two two CD cord-010119-t1x9gknd 4174 44 , , , cord-010119-t1x9gknd 4174 45 and and CC cord-010119-t1x9gknd 4174 46 three three CD cord-010119-t1x9gknd 4174 47 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 4174 48 doses dose NNS cord-010119-t1x9gknd 4174 49 . . . cord-010119-t1x9gknd 4175 1 A a DT cord-010119-t1x9gknd 4175 2 tissue tissue NN cord-010119-t1x9gknd 4175 3 factor factor NN cord-010119-t1x9gknd 4175 4 - - HYPH cord-010119-t1x9gknd 4175 5 activated activate VBN cord-010119-t1x9gknd 4175 6 test test NN cord-010119-t1x9gknd 4175 7 on on IN cord-010119-t1x9gknd 4175 8 the the DT cord-010119-t1x9gknd 4175 9 ROTEMV ROTEMV NNP cord-010119-t1x9gknd 4175 10 R r NN cord-010119-t1x9gknd 4175 11 delta delta NN cord-010119-t1x9gknd 4175 12 hemostasis hemostasis NN cord-010119-t1x9gknd 4175 13 analyzer analyzer NN cord-010119-t1x9gknd 4175 14 ( ( -LRB- cord-010119-t1x9gknd 4175 15 EXTEM EXTEM NNP cord-010119-t1x9gknd 4175 16 ) ) -RRB- cord-010119-t1x9gknd 4175 17 was be VBD cord-010119-t1x9gknd 4175 18 performed perform VBN cord-010119-t1x9gknd 4175 19 on on IN cord-010119-t1x9gknd 4175 20 each each DT cord-010119-t1x9gknd 4175 21 condition condition NN cord-010119-t1x9gknd 4175 22 . . . cord-010119-t1x9gknd 4176 1 For for IN cord-010119-t1x9gknd 4176 2 each each DT cord-010119-t1x9gknd 4176 3 source source NN cord-010119-t1x9gknd 4176 4 , , , cord-010119-t1x9gknd 4176 5 dose dose NN cord-010119-t1x9gknd 4176 6 - - HYPH cord-010119-t1x9gknd 4176 7 response response NN cord-010119-t1x9gknd 4176 8 curves curve NNS cord-010119-t1x9gknd 4176 9 for for IN cord-010119-t1x9gknd 4176 10 clotting clotting NN cord-010119-t1x9gknd 4176 11 time time NN cord-010119-t1x9gknd 4176 12 ( ( -LRB- cord-010119-t1x9gknd 4176 13 CT CT NNP cord-010119-t1x9gknd 4176 14 ) ) -RRB- cord-010119-t1x9gknd 4176 15 , , , cord-010119-t1x9gknd 4176 16 alpha alpha NN cord-010119-t1x9gknd 4176 17 angle angle NN cord-010119-t1x9gknd 4176 18 , , , cord-010119-t1x9gknd 4176 19 and and CC cord-010119-t1x9gknd 4176 20 maximum maximum JJ cord-010119-t1x9gknd 4176 21 clot clot NN cord-010119-t1x9gknd 4176 22 formation formation NN cord-010119-t1x9gknd 4176 23 ( ( -LRB- cord-010119-t1x9gknd 4176 24 MCF MCF NNP cord-010119-t1x9gknd 4176 25 ) ) -RRB- cord-010119-t1x9gknd 4176 26 were be VBD cord-010119-t1x9gknd 4176 27 generated generate VBN cord-010119-t1x9gknd 4176 28 using use VBG cord-010119-t1x9gknd 4176 29 linear linear JJ cord-010119-t1x9gknd 4176 30 regression regression NN cord-010119-t1x9gknd 4176 31 models model NNS cord-010119-t1x9gknd 4176 32 . . . cord-010119-t1x9gknd 4177 1 Inter inter JJ cord-010119-t1x9gknd 4177 2 - - JJ cord-010119-t1x9gknd 4177 3 source source JJ cord-010119-t1x9gknd 4177 4 unit unit NN cord-010119-t1x9gknd 4177 5 variability variability NN cord-010119-t1x9gknd 4177 6 was be VBD cord-010119-t1x9gknd 4177 7 determined determine VBN cord-010119-t1x9gknd 4177 8 by by IN cord-010119-t1x9gknd 4177 9 ANOVA ANOVA NNP cord-010119-t1x9gknd 4177 10 and and CC cord-010119-t1x9gknd 4177 11 Tukey Tukey NNP cord-010119-t1x9gknd 4177 12 's 's POS cord-010119-t1x9gknd 4177 13 HSD HSD NNP cord-010119-t1x9gknd 4177 14 post post VB cord-010119-t1x9gknd 4177 15 - - JJ cord-010119-t1x9gknd 4177 16 hoc hoc JJ cord-010119-t1x9gknd 4177 17 analysis analysis NN cord-010119-t1x9gknd 4177 18 ( ( -LRB- cord-010119-t1x9gknd 4177 19 RStudio RStudio NNP cord-010119-t1x9gknd 4177 20 Inc. Inc. NNP cord-010119-t1x9gknd 4177 21 ) ) -RRB- cord-010119-t1x9gknd 4177 22 . . . cord-010119-t1x9gknd 4178 1 Results result NNS cord-010119-t1x9gknd 4178 2 / / SYM cord-010119-t1x9gknd 4178 3 Finding finding NN cord-010119-t1x9gknd 4178 4 : : : cord-010119-t1x9gknd 4179 1 LC LC NNP cord-010119-t1x9gknd 4179 2 - - HYPH cord-010119-t1x9gknd 4179 3 MS MS NNP cord-010119-t1x9gknd 4179 4 / / SYM cord-010119-t1x9gknd 4179 5 MS MS NNP cord-010119-t1x9gknd 4179 6 identified identify VBD cord-010119-t1x9gknd 4179 7 256 256 CD cord-010119-t1x9gknd 4179 8 proteins protein NNS cord-010119-t1x9gknd 4179 9 in in IN cord-010119-t1x9gknd 4179 10 cryo cryo NN cord-010119-t1x9gknd 4179 11 ; ; : cord-010119-t1x9gknd 4179 12 of of IN cord-010119-t1x9gknd 4179 13 the the DT cord-010119-t1x9gknd 4179 14 10 10 CD cord-010119-t1x9gknd 4179 15 most most RBS cord-010119-t1x9gknd 4179 16 abundant abundant JJ cord-010119-t1x9gknd 4179 17 , , , cord-010119-t1x9gknd 4179 18 only only RB cord-010119-t1x9gknd 4179 19 fibrinogen fibrinogen NN cord-010119-t1x9gknd 4179 20 was be VBD cord-010119-t1x9gknd 4179 21 relevant relevant JJ cord-010119-t1x9gknd 4179 22 to to IN cord-010119-t1x9gknd 4179 23 coagulation coagulation NN cord-010119-t1x9gknd 4179 24 . . . cord-010119-t1x9gknd 4180 1 Notably notably RB cord-010119-t1x9gknd 4180 2 , , , cord-010119-t1x9gknd 4180 3 the the DT cord-010119-t1x9gknd 4180 4 American American NNP cord-010119-t1x9gknd 4180 5 Red Red NNP cord-010119-t1x9gknd 4180 6 Cross Cross NNP cord-010119-t1x9gknd 4180 7 ( ( -LRB- cord-010119-t1x9gknd 4180 8 ARC ARC NNP cord-010119-t1x9gknd 4180 9 ) ) -RRB- cord-010119-t1x9gknd 4180 10 single single JJ cord-010119-t1x9gknd 4180 11 donor donor NN cord-010119-t1x9gknd 4180 12 source source NN cord-010119-t1x9gknd 4180 13 had have VBD cord-010119-t1x9gknd 4180 14 the the DT cord-010119-t1x9gknd 4180 15 steepest steep JJS cord-010119-t1x9gknd 4180 16 slope slope NN cord-010119-t1x9gknd 4180 17 for for IN cord-010119-t1x9gknd 4180 18 MCF MCF NNP cord-010119-t1x9gknd 4180 19 ( ( -LRB- cord-010119-t1x9gknd 4180 20 4.44 4.44 CD cord-010119-t1x9gknd 4180 21 mm mm NN cord-010119-t1x9gknd 4180 22 / / SYM cord-010119-t1x9gknd 4180 23 dose dose NN cord-010119-t1x9gknd 4180 24 ) ) -RRB- cord-010119-t1x9gknd 4180 25 , , , cord-010119-t1x9gknd 4180 26 indicating indicate VBG cord-010119-t1x9gknd 4180 27 a a DT cord-010119-t1x9gknd 4180 28 greater great JJR cord-010119-t1x9gknd 4180 29 per per IN cord-010119-t1x9gknd 4180 30 dose dose JJ cord-010119-t1x9gknd 4180 31 potency potency NN cord-010119-t1x9gknd 4180 32 than than IN cord-010119-t1x9gknd 4180 33 the the DT cord-010119-t1x9gknd 4180 34 other other JJ cord-010119-t1x9gknd 4180 35 sources source NNS cord-010119-t1x9gknd 4180 36 . . . cord-010119-t1x9gknd 4181 1 The the DT cord-010119-t1x9gknd 4181 2 ARC ARC NNP cord-010119-t1x9gknd 4181 3 single single JJ cord-010119-t1x9gknd 4181 4 donor donor NN cord-010119-t1x9gknd 4181 5 source source NN cord-010119-t1x9gknd 4181 6 had have VBD cord-010119-t1x9gknd 4181 7 the the DT cord-010119-t1x9gknd 4181 8 highest high JJS cord-010119-t1x9gknd 4181 9 mean mean JJ cord-010119-t1x9gknd 4181 10 MCF MCF NNP cord-010119-t1x9gknd 4181 11 across across IN cord-010119-t1x9gknd 4181 12 all all DT cord-010119-t1x9gknd 4181 13 dosing dosing NN cord-010119-t1x9gknd 4181 14 levels level NNS cord-010119-t1x9gknd 4181 15 , , , cord-010119-t1x9gknd 4181 16 but but CC cord-010119-t1x9gknd 4181 17 also also RB cord-010119-t1x9gknd 4181 18 the the DT cord-010119-t1x9gknd 4181 19 highest high JJS cord-010119-t1x9gknd 4181 20 standard standard JJ cord-010119-t1x9gknd 4181 21 deviations deviation NNS cord-010119-t1x9gknd 4181 22 and and CC cord-010119-t1x9gknd 4181 23 response response NN cord-010119-t1x9gknd 4181 24 variability variability NN cord-010119-t1x9gknd 4181 25 . . . cord-010119-t1x9gknd 4182 1 The the DT cord-010119-t1x9gknd 4182 2 ARC ARC NNP cord-010119-t1x9gknd 4182 3 single single JJ cord-010119-t1x9gknd 4182 4 donor donor NN cord-010119-t1x9gknd 4182 5 source source NN cord-010119-t1x9gknd 4182 6 was be VBD cord-010119-t1x9gknd 4182 7 significantly significantly RB cord-010119-t1x9gknd 4182 8 more more RBR cord-010119-t1x9gknd 4182 9 potent potent JJ cord-010119-t1x9gknd 4182 10 than than IN cord-010119-t1x9gknd 4182 11 the the DT cord-010119-t1x9gknd 4182 12 Australian australian JJ cord-010119-t1x9gknd 4182 13 source source NN cord-010119-t1x9gknd 4182 14 . . . cord-010119-t1x9gknd 4183 1 Conclusion conclusion NN cord-010119-t1x9gknd 4183 2 : : : cord-010119-t1x9gknd 4184 1 Paired pair VBN cord-010119-t1x9gknd 4184 2 with with IN cord-010119-t1x9gknd 4184 3 our -PRON- PRP$ cord-010119-t1x9gknd 4184 4 estimates estimate NNS cord-010119-t1x9gknd 4184 5 regarding regard VBG cord-010119-t1x9gknd 4184 6 the the DT cord-010119-t1x9gknd 4184 7 variability variability NN cord-010119-t1x9gknd 4184 8 of of IN cord-010119-t1x9gknd 4184 9 clot clot NN cord-010119-t1x9gknd 4184 10 formation formation NN cord-010119-t1x9gknd 4184 11 responses response NNS cord-010119-t1x9gknd 4184 12 to to IN cord-010119-t1x9gknd 4184 13 cryo cryo NN cord-010119-t1x9gknd 4184 14 , , , cord-010119-t1x9gknd 4184 15 the the DT cord-010119-t1x9gknd 4184 16 quantitative quantitative JJ cord-010119-t1x9gknd 4184 17 dose dose NN cord-010119-t1x9gknd 4184 18 - - HYPH cord-010119-t1x9gknd 4184 19 response response NN cord-010119-t1x9gknd 4184 20 curves curve NNS cord-010119-t1x9gknd 4184 21 provided provide VBN cord-010119-t1x9gknd 4184 22 in in IN cord-010119-t1x9gknd 4184 23 this this DT cord-010119-t1x9gknd 4184 24 study study NN cord-010119-t1x9gknd 4184 25 for for IN cord-010119-t1x9gknd 4184 26 CT CT NNP cord-010119-t1x9gknd 4184 27 , , , cord-010119-t1x9gknd 4184 28 MCF MCF NNP cord-010119-t1x9gknd 4184 29 , , , cord-010119-t1x9gknd 4184 30 and and CC cord-010119-t1x9gknd 4184 31 alpha alpha NN cord-010119-t1x9gknd 4184 32 angle angle NN cord-010119-t1x9gknd 4184 33 can can MD cord-010119-t1x9gknd 4184 34 provide provide VB cord-010119-t1x9gknd 4184 35 physicians physician NNS cord-010119-t1x9gknd 4184 36 with with IN cord-010119-t1x9gknd 4184 37 more more JJR cord-010119-t1x9gknd 4184 38 information information NN cord-010119-t1x9gknd 4184 39 regarding regard VBG cord-010119-t1x9gknd 4184 40 cryo cryo NN cord-010119-t1x9gknd 4184 41 dosing dosing NN cord-010119-t1x9gknd 4184 42 . . . cord-010119-t1x9gknd 4185 1 Future future JJ cord-010119-t1x9gknd 4185 2 studies study NNS cord-010119-t1x9gknd 4185 3 that that WDT cord-010119-t1x9gknd 4185 4 evaluate evaluate VBP cord-010119-t1x9gknd 4185 5 the the DT cord-010119-t1x9gknd 4185 6 therapeutic therapeutic JJ cord-010119-t1x9gknd 4185 7 effect effect NN cord-010119-t1x9gknd 4185 8 of of IN cord-010119-t1x9gknd 4185 9 cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 4185 10 versus versus IN cord-010119-t1x9gknd 4185 11 fresh fresh JJ cord-010119-t1x9gknd 4185 12 frozen frozen JJ cord-010119-t1x9gknd 4185 13 plasma plasma NN cord-010119-t1x9gknd 4185 14 or or CC cord-010119-t1x9gknd 4185 15 fibrinogen fibrinogen NN cord-010119-t1x9gknd 4185 16 concentrate concentrate NN cord-010119-t1x9gknd 4185 17 would would MD cord-010119-t1x9gknd 4185 18 be be VB cord-010119-t1x9gknd 4185 19 of of IN cord-010119-t1x9gknd 4185 20 clinical clinical JJ cord-010119-t1x9gknd 4185 21 importance importance NN cord-010119-t1x9gknd 4185 22 and and CC cord-010119-t1x9gknd 4185 23 give give VB cord-010119-t1x9gknd 4185 24 us -PRON- PRP cord-010119-t1x9gknd 4185 25 further further JJ cord-010119-t1x9gknd 4185 26 insight insight NN cord-010119-t1x9gknd 4185 27 into into IN cord-010119-t1x9gknd 4185 28 the the DT cord-010119-t1x9gknd 4185 29 relative relative JJ cord-010119-t1x9gknd 4185 30 utility utility NN cord-010119-t1x9gknd 4185 31 of of IN cord-010119-t1x9gknd 4185 32 and and CC cord-010119-t1x9gknd 4185 33 dose dose NN cord-010119-t1x9gknd 4185 34 requirements requirement NNS cord-010119-t1x9gknd 4185 35 for for IN cord-010119-t1x9gknd 4185 36 cryo cryo NN cord-010119-t1x9gknd 4185 37 to to TO cord-010119-t1x9gknd 4185 38 correct correct VB cord-010119-t1x9gknd 4185 39 dilutional dilutional JJ cord-010119-t1x9gknd 4185 40 coagulopathy coagulopathy NN cord-010119-t1x9gknd 4185 41 . . . cord-010119-t1x9gknd 4186 1 Viral Viral NNP cord-010119-t1x9gknd 4186 2 Inactivation Inactivation NNP cord-010119-t1x9gknd 4186 3 and and CC cord-010119-t1x9gknd 4186 4 Enrichment Enrichment NNP cord-010119-t1x9gknd 4186 5 of of IN cord-010119-t1x9gknd 4186 6 Factor Factor NNP cord-010119-t1x9gknd 4186 7 VIII VIII NNP cord-010119-t1x9gknd 4186 8 , , , cord-010119-t1x9gknd 4186 9 Factor Factor NNP cord-010119-t1x9gknd 4186 10 XIII XIII NNP cord-010119-t1x9gknd 4186 11 , , , cord-010119-t1x9gknd 4187 1 Fibrinogen Fibrinogen NNP cord-010119-t1x9gknd 4187 2 and and CC cord-010119-t1x9gknd 4187 3 Von Von NNP cord-010119-t1x9gknd 4187 4 Willebrand Willebrand NNP cord-010119-t1x9gknd 4187 5 Factor Factor NNP cord-010119-t1x9gknd 4187 6 ( ( -LRB- cord-010119-t1x9gknd 4187 7 VWF VWF NNP cord-010119-t1x9gknd 4187 8 ) ) -RRB- cord-010119-t1x9gknd 4187 9 Multimers Multimers NNPS cord-010119-t1x9gknd 4187 10 from from IN cord-010119-t1x9gknd 4187 11 Fresh Fresh NNP cord-010119-t1x9gknd 4187 12 Frozen Frozen NNP cord-010119-t1x9gknd 4187 13 Plasma Plasma NNP cord-010119-t1x9gknd 4187 14 ( ( -LRB- cord-010119-t1x9gknd 4187 15 FFP)Using ffp)using NN cord-010119-t1x9gknd 4187 16 , , , cord-010119-t1x9gknd 4187 17 " " '' cord-010119-t1x9gknd 4187 18 VIPS VIPS NNP cord-010119-t1x9gknd 4187 19 Plasma Plasma NNP cord-010119-t1x9gknd 4187 20 , , , cord-010119-t1x9gknd 4187 21 Virus Virus NNP cord-010119-t1x9gknd 4187 22 Inactivation Inactivation NNP cord-010119-t1x9gknd 4187 23 Treatment Treatment NNP cord-010119-t1x9gknd 4187 24 System System NNP cord-010119-t1x9gknd 4187 25 " " '' cord-010119-t1x9gknd 4187 26 . . . cord-010119-t1x9gknd 4188 1 Background Background NNP cord-010119-t1x9gknd 4188 2 / / SYM cord-010119-t1x9gknd 4188 3 Case Case NNP cord-010119-t1x9gknd 4188 4 Studies Studies NNPS cord-010119-t1x9gknd 4188 5 : : : cord-010119-t1x9gknd 4188 6 The the DT cord-010119-t1x9gknd 4188 7 solvent solvent NN cord-010119-t1x9gknd 4188 8 / / SYM cord-010119-t1x9gknd 4188 9 detergent detergent NN cord-010119-t1x9gknd 4188 10 ( ( -LRB- cord-010119-t1x9gknd 4188 11 SD SD NNP cord-010119-t1x9gknd 4188 12 ) ) -RRB- cord-010119-t1x9gknd 4188 13 process process NN cord-010119-t1x9gknd 4188 14 used use VBN cord-010119-t1x9gknd 4188 15 for for IN cord-010119-t1x9gknd 4188 16 plasma plasma NN cord-010119-t1x9gknd 4188 17 can can MD cord-010119-t1x9gknd 4188 18 safely safely RB cord-010119-t1x9gknd 4188 19 inactivate inactivate VB cord-010119-t1x9gknd 4188 20 all all DT cord-010119-t1x9gknd 4188 21 lipid lipid NN cord-010119-t1x9gknd 4188 22 - - HYPH cord-010119-t1x9gknd 4188 23 enveloped envelop VBN cord-010119-t1x9gknd 4188 24 viruses virus NNS cord-010119-t1x9gknd 4188 25 . . . cord-010119-t1x9gknd 4189 1 The the DT cord-010119-t1x9gknd 4189 2 method method NN cord-010119-t1x9gknd 4189 3 proved prove VBD cord-010119-t1x9gknd 4189 4 effective effective JJ cord-010119-t1x9gknd 4189 5 in in IN cord-010119-t1x9gknd 4189 6 the the DT cord-010119-t1x9gknd 4189 7 processing processing NN cord-010119-t1x9gknd 4189 8 of of IN cord-010119-t1x9gknd 4189 9 coagulation coagulation NN cord-010119-t1x9gknd 4189 10 factor factor NN cord-010119-t1x9gknd 4189 11 concentrates concentrate VBZ cord-010119-t1x9gknd 4189 12 by by IN cord-010119-t1x9gknd 4189 13 disrupting disrupt VBG cord-010119-t1x9gknd 4189 14 the the DT cord-010119-t1x9gknd 4189 15 membranes membrane NNS cord-010119-t1x9gknd 4189 16 of of IN cord-010119-t1x9gknd 4189 17 lipid lipid NN cord-010119-t1x9gknd 4189 18 - - HYPH cord-010119-t1x9gknd 4189 19 enveloped envelop VBN cord-010119-t1x9gknd 4189 20 viruses virus NNS cord-010119-t1x9gknd 4189 21 , , , cord-010119-t1x9gknd 4189 22 cells cell NNS cord-010119-t1x9gknd 4189 23 and and CC cord-010119-t1x9gknd 4189 24 most most JJS cord-010119-t1x9gknd 4189 25 protozoa protozoan NNS cord-010119-t1x9gknd 4189 26 , , , cord-010119-t1x9gknd 4189 27 while while IN cord-010119-t1x9gknd 4189 28 leaving leave VBG cord-010119-t1x9gknd 4189 29 the the DT cord-010119-t1x9gknd 4189 30 labile labile JJ cord-010119-t1x9gknd 4189 31 coagulation coagulation NN cord-010119-t1x9gknd 4189 32 factors factor NNS cord-010119-t1x9gknd 4189 33 intact intact JJ cord-010119-t1x9gknd 4189 34 . . . cord-010119-t1x9gknd 4190 1 This this DT cord-010119-t1x9gknd 4190 2 study study NN cord-010119-t1x9gknd 4190 3 is be VBZ cord-010119-t1x9gknd 4190 4 done do VBN cord-010119-t1x9gknd 4190 5 to to TO cord-010119-t1x9gknd 4190 6 assess assess VB cord-010119-t1x9gknd 4190 7 viral viral JJ cord-010119-t1x9gknd 4190 8 inactivation inactivation NN cord-010119-t1x9gknd 4190 9 and and CC cord-010119-t1x9gknd 4190 10 , , , cord-010119-t1x9gknd 4190 11 Factor Factor NNP cord-010119-t1x9gknd 4190 12 VIII VIII NNP cord-010119-t1x9gknd 4190 13 , , , cord-010119-t1x9gknd 4190 14 Factor Factor NNP cord-010119-t1x9gknd 4190 15 XIII XIII NNP cord-010119-t1x9gknd 4190 16 , , , cord-010119-t1x9gknd 4190 17 Fibrinogen Fibrinogen NNP cord-010119-t1x9gknd 4190 18 and and CC cord-010119-t1x9gknd 4190 19 von von NNP cord-010119-t1x9gknd 4190 20 Willebrand Willebrand NNP cord-010119-t1x9gknd 4190 21 factor factor NN cord-010119-t1x9gknd 4190 22 ( ( -LRB- cord-010119-t1x9gknd 4190 23 VWF VWF NNP cord-010119-t1x9gknd 4190 24 ) ) -RRB- cord-010119-t1x9gknd 4191 1 multimers multimers NNP cord-010119-t1x9gknd 4191 2 enrichment enrichment NN cord-010119-t1x9gknd 4191 3 capacity capacity NN cord-010119-t1x9gknd 4191 4 of of IN cord-010119-t1x9gknd 4191 5 , , , cord-010119-t1x9gknd 4191 6 " " '' cord-010119-t1x9gknd 4191 7 VIPS VIPS NNP cord-010119-t1x9gknd 4191 8 Plasma Plasma NNP cord-010119-t1x9gknd 4191 9 , , , cord-010119-t1x9gknd 4191 10 Virus Virus NNP cord-010119-t1x9gknd 4191 11 Inactivation Inactivation NNP cord-010119-t1x9gknd 4191 12 Treatment Treatment NNP cord-010119-t1x9gknd 4191 13 System System NNP cord-010119-t1x9gknd 4191 14 " " '' cord-010119-t1x9gknd 4191 15 . . . cord-010119-t1x9gknd 4192 1 Study Study NNP cord-010119-t1x9gknd 4192 2 Design Design NNP cord-010119-t1x9gknd 4192 3 / / SYM cord-010119-t1x9gknd 4192 4 Method method NN cord-010119-t1x9gknd 4192 5 : : : cord-010119-t1x9gknd 4192 6 " " `` cord-010119-t1x9gknd 4192 7 VIPS VIPS NNP cord-010119-t1x9gknd 4192 8 Plasma Plasma NNP cord-010119-t1x9gknd 4192 9 , , , cord-010119-t1x9gknd 4192 10 Virus Virus NNP cord-010119-t1x9gknd 4192 11 Inactivation Inactivation NNP cord-010119-t1x9gknd 4192 12 Treatment Treatment NNP cord-010119-t1x9gknd 4192 13 System System NNP cord-010119-t1x9gknd 4192 14 " " '' cord-010119-t1x9gknd 4192 15 comprise comprise VBP cord-010119-t1x9gknd 4192 16 of of IN cord-010119-t1x9gknd 4192 17 interconnected interconnected JJ cord-010119-t1x9gknd 4192 18 bag bag NN cord-010119-t1x9gknd 4192 19 system system NN cord-010119-t1x9gknd 4192 20 where where WRB cord-010119-t1x9gknd 4192 21 the the DT cord-010119-t1x9gknd 4192 22 S S NNP cord-010119-t1x9gknd 4192 23 / / SYM cord-010119-t1x9gknd 4192 24 D d NN cord-010119-t1x9gknd 4192 25 reagents reagent NNS cord-010119-t1x9gknd 4192 26 are be VBP cord-010119-t1x9gknd 4192 27 removed remove VBN cord-010119-t1x9gknd 4192 28 by by IN cord-010119-t1x9gknd 4192 29 filtration filtration NN cord-010119-t1x9gknd 4192 30 and and CC cord-010119-t1x9gknd 4192 31 the the DT cord-010119-t1x9gknd 4192 32 final final JJ cord-010119-t1x9gknd 4192 33 products product NNS cord-010119-t1x9gknd 4192 34 subjected subject VBN cord-010119-t1x9gknd 4192 35 to to IN cord-010119-t1x9gknd 4192 36 bacterial bacterial JJ cord-010119-t1x9gknd 4192 37 ( ( -LRB- cord-010119-t1x9gknd 4192 38 0Á2 0á2 CD cord-010119-t1x9gknd 4192 39 lm lm NNP cord-010119-t1x9gknd 4192 40 ) ) -RRB- cord-010119-t1x9gknd 4192 41 filtration filtration NN cord-010119-t1x9gknd 4192 42 . . . cord-010119-t1x9gknd 4193 1 Cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 4193 2 mini mini NN cord-010119-t1x9gknd 4193 3 - - NNS cord-010119-t1x9gknd 4193 4 pools pool NNS cord-010119-t1x9gknd 4193 5 ( ( -LRB- cord-010119-t1x9gknd 4193 6 400 400 CD cord-010119-t1x9gknd 4193 7 6 6 CD cord-010119-t1x9gknd 4193 8 20 20 CD cord-010119-t1x9gknd 4193 9 mL ml NN cord-010119-t1x9gknd 4193 10 ) ) -RRB- cord-010119-t1x9gknd 4193 11 were be VBD cord-010119-t1x9gknd 4193 12 subjected subject VBN cord-010119-t1x9gknd 4193 13 to to IN cord-010119-t1x9gknd 4193 14 doublestage doublestage NNP cord-010119-t1x9gknd 4193 15 S S NNP cord-010119-t1x9gknd 4193 16 / / SYM cord-010119-t1x9gknd 4193 17 D D NNP cord-010119-t1x9gknd 4193 18 viral viral JJ cord-010119-t1x9gknd 4193 19 inactivation inactivation NN cord-010119-t1x9gknd 4193 20 , , , cord-010119-t1x9gknd 4193 21 followed follow VBN cord-010119-t1x9gknd 4193 22 by by IN cord-010119-t1x9gknd 4193 23 one one CD cord-010119-t1x9gknd 4193 24 oil oil NN cord-010119-t1x9gknd 4193 25 extraction extraction NN cord-010119-t1x9gknd 4193 26 and and CC cord-010119-t1x9gknd 4193 27 a a DT cord-010119-t1x9gknd 4193 28 filtration filtration NN cord-010119-t1x9gknd 4193 29 on on IN cord-010119-t1x9gknd 4193 30 a a DT cord-010119-t1x9gknd 4193 31 S s NN cord-010119-t1x9gknd 4193 32 / / SYM cord-010119-t1x9gknd 4193 33 D d NN cord-010119-t1x9gknd 4193 34 and and CC cord-010119-t1x9gknd 4193 35 phthalate phthalate NN cord-010119-t1x9gknd 4193 36 [ [ -LRB- cord-010119-t1x9gknd 4193 37 di(2-ethylhexyl di(2-ethylhexyl NNP cord-010119-t1x9gknd 4193 38 ) ) -RRB- cord-010119-t1x9gknd 4193 39 phthalate phthalate NN cord-010119-t1x9gknd 4193 40 ( ( -LRB- cord-010119-t1x9gknd 4193 41 DEHP DEHP NNP cord-010119-t1x9gknd 4193 42 ) ) -RRB- cord-010119-t1x9gknd 4193 43 ] ] -RRB- cord-010119-t1x9gknd 4194 1 adsorption adsorption NN cord-010119-t1x9gknd 4194 2 device device NN cord-010119-t1x9gknd 4194 3 and and CC cord-010119-t1x9gknd 4194 4 a a DT cord-010119-t1x9gknd 4194 5 0Á2 0á2 CD cord-010119-t1x9gknd 4194 6 lm lm XX cord-010119-t1x9gknd 4194 7 filter filter NN cord-010119-t1x9gknd 4194 8 . . . cord-010119-t1x9gknd 4195 1 The the DT cord-010119-t1x9gknd 4195 2 initial initial JJ cord-010119-t1x9gknd 4195 3 and and CC cord-010119-t1x9gknd 4195 4 the the DT cord-010119-t1x9gknd 4195 5 final final JJ cord-010119-t1x9gknd 4195 6 products product NNS cord-010119-t1x9gknd 4195 7 were be VBD cord-010119-t1x9gknd 4195 8 compared compare VBN cord-010119-t1x9gknd 4195 9 for for IN cord-010119-t1x9gknd 4195 10 visual visual JJ cord-010119-t1x9gknd 4195 11 appearance appearance NN cord-010119-t1x9gknd 4195 12 , , , cord-010119-t1x9gknd 4195 13 blood blood NN cord-010119-t1x9gknd 4195 14 cell cell NN cord-010119-t1x9gknd 4195 15 count count NN cord-010119-t1x9gknd 4195 16 , , , cord-010119-t1x9gknd 4195 17 factor factor NN cord-010119-t1x9gknd 4195 18 VIII VIII NNP cord-010119-t1x9gknd 4195 19 , , , cord-010119-t1x9gknd 4195 20 Factor Factor NNP cord-010119-t1x9gknd 4195 21 XIII XIII NNP cord-010119-t1x9gknd 4195 22 , , , cord-010119-t1x9gknd 4195 23 Fibrinogen Fibrinogen NNP cord-010119-t1x9gknd 4195 24 and and CC cord-010119-t1x9gknd 4195 25 Von Von NNP cord-010119-t1x9gknd 4195 26 Willebrand Willebrand NNP cord-010119-t1x9gknd 4195 27 factor factor NN cord-010119-t1x9gknd 4195 28 ( ( -LRB- cord-010119-t1x9gknd 4195 29 VWF VWF NNP cord-010119-t1x9gknd 4195 30 ) ) -RRB- cord-010119-t1x9gknd 4195 31 multimers multimer NNS cord-010119-t1x9gknd 4195 32 . . . cord-010119-t1x9gknd 4196 1 Initial initial JJ cord-010119-t1x9gknd 4196 2 and and CC cord-010119-t1x9gknd 4196 3 final final JJ cord-010119-t1x9gknd 4196 4 products product NNS cord-010119-t1x9gknd 4196 5 were be VBD cord-010119-t1x9gknd 4196 6 also also RB cord-010119-t1x9gknd 4196 7 checked check VBN cord-010119-t1x9gknd 4196 8 for for IN cord-010119-t1x9gknd 4196 9 HIV HIV NNP cord-010119-t1x9gknd 4196 10 , , , cord-010119-t1x9gknd 4196 11 HBV HBV NNP cord-010119-t1x9gknd 4196 12 , , , cord-010119-t1x9gknd 4196 13 HCV HCV NNP cord-010119-t1x9gknd 4196 14 , , , cord-010119-t1x9gknd 4196 15 dengue dengue NN cord-010119-t1x9gknd 4196 16 , , , cord-010119-t1x9gknd 4196 17 malaria malaria NN cord-010119-t1x9gknd 4196 18 and and CC cord-010119-t1x9gknd 4196 19 bacterial bacterial JJ cord-010119-t1x9gknd 4196 20 contaminations contamination NNS cord-010119-t1x9gknd 4196 21 . . . cord-010119-t1x9gknd 4197 1 Results/ Results/ . cord-010119-t1x9gknd 4198 1 Finding finding NN cord-010119-t1x9gknd 4198 2 : : : cord-010119-t1x9gknd 4199 1 Our -PRON- PRP$ cord-010119-t1x9gknd 4199 2 analysis analysis NN cord-010119-t1x9gknd 4199 3 showed show VBD cord-010119-t1x9gknd 4199 4 that that IN cord-010119-t1x9gknd 4199 5 the the DT cord-010119-t1x9gknd 4199 6 treated treat VBN cord-010119-t1x9gknd 4199 7 cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 4199 8 were be VBD cord-010119-t1x9gknd 4199 9 very very RB cord-010119-t1x9gknd 4199 10 clear clear JJ cord-010119-t1x9gknd 4199 11 , , , cord-010119-t1x9gknd 4199 12 with with IN cord-010119-t1x9gknd 4199 13 negative negative JJ cord-010119-t1x9gknd 4199 14 blood blood NN cord-010119-t1x9gknd 4199 15 count count NN cord-010119-t1x9gknd 4199 16 and and CC cord-010119-t1x9gknd 4199 17 the the DT cord-010119-t1x9gknd 4199 18 protein protein NN cord-010119-t1x9gknd 4199 19 content content NN cord-010119-t1x9gknd 4199 20 of of IN cord-010119-t1x9gknd 4199 21 factor factor NN cord-010119-t1x9gknd 4199 22 VIII VIII NNP cord-010119-t1x9gknd 4199 23 , , , cord-010119-t1x9gknd 4199 24 Factor Factor NNP cord-010119-t1x9gknd 4199 25 XIII XIII NNP cord-010119-t1x9gknd 4199 26 , , , cord-010119-t1x9gknd 4200 1 Fibrinogen fibrinogen NN cord-010119-t1x9gknd 4200 2 and and CC cord-010119-t1x9gknd 4200 3 von von NNP cord-010119-t1x9gknd 4200 4 Willebrand Willebrand NNP cord-010119-t1x9gknd 4200 5 factor factor NN cord-010119-t1x9gknd 4200 6 ( ( -LRB- cord-010119-t1x9gknd 4200 7 VWF VWF NNP cord-010119-t1x9gknd 4200 8 ) ) -RRB- cord-010119-t1x9gknd 4200 9 multimers multimer NNS cord-010119-t1x9gknd 4200 10 were be VBD cord-010119-t1x9gknd 4200 11 well well RB cord-010119-t1x9gknd 4200 12 conserved conserved JJ cord-010119-t1x9gknd 4200 13 ( ( -LRB- cord-010119-t1x9gknd 4200 14 Table table NN cord-010119-t1x9gknd 4200 15 1 1 CD cord-010119-t1x9gknd 4200 16 ) ) -RRB- cord-010119-t1x9gknd 4200 17 . . . cord-010119-t1x9gknd 4201 1 Kit kit NN cord-010119-t1x9gknd 4201 2 ensured ensure VBD cord-010119-t1x9gknd 4201 3 bacterial bacterial JJ cord-010119-t1x9gknd 4201 4 sterility sterility NN cord-010119-t1x9gknd 4201 5 ( ( -LRB- cord-010119-t1x9gknd 4201 6 Table table NN cord-010119-t1x9gknd 4201 7 3 3 CD cord-010119-t1x9gknd 4201 8 ) ) -RRB- cord-010119-t1x9gknd 4201 9 and and CC cord-010119-t1x9gknd 4201 10 most most RBS cord-010119-t1x9gknd 4201 11 importantly importantly RB cord-010119-t1x9gknd 4201 12 , , , cord-010119-t1x9gknd 4201 13 final final JJ cord-010119-t1x9gknd 4201 14 product product NN cord-010119-t1x9gknd 4201 15 was be VBD cord-010119-t1x9gknd 4201 16 free free JJ cord-010119-t1x9gknd 4201 17 of of IN cord-010119-t1x9gknd 4201 18 HBV HBV NNP cord-010119-t1x9gknd 4201 19 , , , cord-010119-t1x9gknd 4201 20 HCV HCV NNP cord-010119-t1x9gknd 4201 21 and and CC cord-010119-t1x9gknd 4201 22 HIV HIV NNP cord-010119-t1x9gknd 4201 23 ( ( -LRB- cord-010119-t1x9gknd 4201 24 Table Table NNP cord-010119-t1x9gknd 4201 25 2 2 CD cord-010119-t1x9gknd 4201 26 ) ) -RRB- cord-010119-t1x9gknd 4201 27 . . . cord-010119-t1x9gknd 4202 1 Conclusion conclusion NN cord-010119-t1x9gknd 4202 2 : : : cord-010119-t1x9gknd 4203 1 It -PRON- PRP cord-010119-t1x9gknd 4203 2 's be VBZ cord-010119-t1x9gknd 4203 3 the the DT cord-010119-t1x9gknd 4203 4 first first JJ cord-010119-t1x9gknd 4203 5 time time NN cord-010119-t1x9gknd 4203 6 , , , cord-010119-t1x9gknd 4203 7 " " '' cord-010119-t1x9gknd 4203 8 VIPS VIPS NNP cord-010119-t1x9gknd 4203 9 Plasma Plasma NNP cord-010119-t1x9gknd 4203 10 , , , cord-010119-t1x9gknd 4203 11 Virus Virus NNP cord-010119-t1x9gknd 4203 12 Inactivation Inactivation NNP cord-010119-t1x9gknd 4203 13 Treatment Treatment NNP cord-010119-t1x9gknd 4203 14 System System NNP cord-010119-t1x9gknd 4203 15 " " '' cord-010119-t1x9gknd 4203 16 , , , cord-010119-t1x9gknd 4203 17 is be VBZ cord-010119-t1x9gknd 4203 18 used use VBN cord-010119-t1x9gknd 4203 19 in in IN cord-010119-t1x9gknd 4203 20 South South NNP cord-010119-t1x9gknd 4203 21 Asia Asia NNP cord-010119-t1x9gknd 4203 22 for for IN cord-010119-t1x9gknd 4203 23 product product NN cord-010119-t1x9gknd 4203 24 enrichment enrichment NN cord-010119-t1x9gknd 4203 25 and and CC cord-010119-t1x9gknd 4203 26 viral viral JJ cord-010119-t1x9gknd 4203 27 inactivation inactivation NN cord-010119-t1x9gknd 4203 28 . . . cord-010119-t1x9gknd 4204 1 Results result NNS cord-010119-t1x9gknd 4204 2 showed show VBD cord-010119-t1x9gknd 4204 3 effective effective JJ cord-010119-t1x9gknd 4204 4 product product NN cord-010119-t1x9gknd 4204 5 enrichment enrichment NN cord-010119-t1x9gknd 4204 6 and and CC cord-010119-t1x9gknd 4204 7 viral viral JJ cord-010119-t1x9gknd 4204 8 inactivation inactivation NN cord-010119-t1x9gknd 4204 9 in in IN cord-010119-t1x9gknd 4204 10 our -PRON- PRP$ cord-010119-t1x9gknd 4204 11 conditions condition NNS cord-010119-t1x9gknd 4204 12 . . . cord-010119-t1x9gknd 4205 1 But but CC cord-010119-t1x9gknd 4205 2 further further JJ cord-010119-t1x9gknd 4205 3 investigation investigation NN cord-010119-t1x9gknd 4205 4 is be VBZ cord-010119-t1x9gknd 4205 5 needed need VBN cord-010119-t1x9gknd 4205 6 to to TO cord-010119-t1x9gknd 4205 7 characterize characterize VB cord-010119-t1x9gknd 4205 8 functional functional JJ cord-010119-t1x9gknd 4205 9 activity activity NN cord-010119-t1x9gknd 4205 10 of of IN cord-010119-t1x9gknd 4205 11 the the DT cord-010119-t1x9gknd 4205 12 enrich enrich JJ cord-010119-t1x9gknd 4205 13 component component NN cord-010119-t1x9gknd 4205 14 . . . cord-010119-t1x9gknd 4206 1 Irrespective irrespective RB cord-010119-t1x9gknd 4206 2 of of IN cord-010119-t1x9gknd 4206 3 that that DT cord-010119-t1x9gknd 4206 4 the the DT cord-010119-t1x9gknd 4206 5 process process NN cord-010119-t1x9gknd 4206 6 may may MD cord-010119-t1x9gknd 4206 7 offer offer VB cord-010119-t1x9gknd 4206 8 one one CD cord-010119-t1x9gknd 4206 9 additional additional JJ cord-010119-t1x9gknd 4206 10 option option NN cord-010119-t1x9gknd 4206 11 to to TO cord-010119-t1x9gknd 4206 12 blood blood NN cord-010119-t1x9gknd 4206 13 establishments establishment NNS cord-010119-t1x9gknd 4206 14 for for IN cord-010119-t1x9gknd 4206 15 the the DT cord-010119-t1x9gknd 4206 16 production production NN cord-010119-t1x9gknd 4206 17 of of IN cord-010119-t1x9gknd 4206 18 virally virally RB cord-010119-t1x9gknd 4206 19 inactivated inactivate VBN cord-010119-t1x9gknd 4206 20 plasma plasma NN cord-010119-t1x9gknd 4206 21 components component NNS cord-010119-t1x9gknd 4206 22 especially especially RB cord-010119-t1x9gknd 4206 23 in in IN cord-010119-t1x9gknd 4206 24 low low JJ cord-010119-t1x9gknd 4206 25 income income NN cord-010119-t1x9gknd 4206 26 countries country NNS cord-010119-t1x9gknd 4206 27 . . . cord-010119-t1x9gknd 4207 1 Background Background NNP cord-010119-t1x9gknd 4207 2 / / SYM cord-010119-t1x9gknd 4207 3 Case Case NNP cord-010119-t1x9gknd 4207 4 Studies Studies NNPS cord-010119-t1x9gknd 4207 5 : : : cord-010119-t1x9gknd 4207 6 Buffy Buffy NNP cord-010119-t1x9gknd 4207 7 coats coat NNS cord-010119-t1x9gknd 4207 8 ( ( -LRB- cord-010119-t1x9gknd 4207 9 BC BC NNP cord-010119-t1x9gknd 4207 10 ) ) -RRB- cord-010119-t1x9gknd 4207 11 from from IN cord-010119-t1x9gknd 4207 12 donors donor NNS cord-010119-t1x9gknd 4207 13 who who WP cord-010119-t1x9gknd 4207 14 used use VBD cord-010119-t1x9gknd 4207 15 pain pain NN cord-010119-t1x9gknd 4207 16 medication medication NN cord-010119-t1x9gknd 4207 17 like like IN cord-010119-t1x9gknd 4207 18 aspirin aspirin NN cord-010119-t1x9gknd 4207 19 and and CC cord-010119-t1x9gknd 4207 20 ibuprofen ibuprofen VB cord-010119-t1x9gknd 4207 21 up up RP cord-010119-t1x9gknd 4207 22 to to TO cord-010119-t1x9gknd 4207 23 4 4 CD cord-010119-t1x9gknd 4207 24 days day NNS cord-010119-t1x9gknd 4207 25 prior prior RB cord-010119-t1x9gknd 4207 26 to to IN cord-010119-t1x9gknd 4207 27 the the DT cord-010119-t1x9gknd 4207 28 donation donation NN cord-010119-t1x9gknd 4207 29 are be VBP cord-010119-t1x9gknd 4207 30 discarded discard VBN cord-010119-t1x9gknd 4207 31 , , , cord-010119-t1x9gknd 4207 32 because because IN cord-010119-t1x9gknd 4207 33 a a DT cord-010119-t1x9gknd 4207 34 known know VBN cord-010119-t1x9gknd 4207 35 side side NN cord-010119-t1x9gknd 4207 36 effect effect NN cord-010119-t1x9gknd 4207 37 of of IN cord-010119-t1x9gknd 4207 38 these these DT cord-010119-t1x9gknd 4207 39 non non JJ cord-010119-t1x9gknd 4207 40 - - JJ cord-010119-t1x9gknd 4207 41 steroidal steroidal JJ cord-010119-t1x9gknd 4207 42 anti anti JJ cord-010119-t1x9gknd 4207 43 - - JJ cord-010119-t1x9gknd 4207 44 inflammatory inflammatory JJ cord-010119-t1x9gknd 4207 45 drugs drug NNS cord-010119-t1x9gknd 4207 46 ( ( -LRB- cord-010119-t1x9gknd 4207 47 NSAIDs nsaid NNS cord-010119-t1x9gknd 4207 48 ) ) -RRB- cord-010119-t1x9gknd 4207 49 is be VBZ cord-010119-t1x9gknd 4207 50 inhibition inhibition NN cord-010119-t1x9gknd 4207 51 of of IN cord-010119-t1x9gknd 4207 52 platelet platelet NN cord-010119-t1x9gknd 4207 53 ( ( -LRB- cord-010119-t1x9gknd 4207 54 PLT PLT NNP cord-010119-t1x9gknd 4207 55 ) ) -RRB- cord-010119-t1x9gknd 4207 56 aggregation aggregation NN cord-010119-t1x9gknd 4207 57 . . . cord-010119-t1x9gknd 4208 1 These these DT cord-010119-t1x9gknd 4208 2 NSAIDs nsaid NNS cord-010119-t1x9gknd 4208 3 inhibit inhibit VBP cord-010119-t1x9gknd 4208 4 the the DT cord-010119-t1x9gknd 4208 5 enzyme enzyme NN cord-010119-t1x9gknd 4208 6 cyclooxygenase-1 cyclooxygenase-1 NN cord-010119-t1x9gknd 4208 7 , , , cord-010119-t1x9gknd 4208 8 thereby thereby RB cord-010119-t1x9gknd 4208 9 blocking block VBG cord-010119-t1x9gknd 4208 10 synthesis synthesis NN cord-010119-t1x9gknd 4208 11 of of IN cord-010119-t1x9gknd 4208 12 thromboxane thromboxane NN cord-010119-t1x9gknd 4208 13 A A NNP cord-010119-t1x9gknd 4208 14 2 2 CD cord-010119-t1x9gknd 4208 15 from from IN cord-010119-t1x9gknd 4208 16 arachidonic arachidonic JJ cord-010119-t1x9gknd 4208 17 acid acid NN cord-010119-t1x9gknd 4208 18 . . . cord-010119-t1x9gknd 4209 1 However however RB cord-010119-t1x9gknd 4209 2 , , , cord-010119-t1x9gknd 4209 3 the the DT cord-010119-t1x9gknd 4209 4 quality quality NN cord-010119-t1x9gknd 4209 5 of of IN cord-010119-t1x9gknd 4209 6 platelet platelet NN cord-010119-t1x9gknd 4209 7 concentrates concentrate NNS cord-010119-t1x9gknd 4209 8 ( ( -LRB- cord-010119-t1x9gknd 4209 9 PC pc NN cord-010119-t1x9gknd 4209 10 ) ) -RRB- cord-010119-t1x9gknd 4209 11 , , , cord-010119-t1x9gknd 4209 12 prepared prepare VBN cord-010119-t1x9gknd 4209 13 from from IN cord-010119-t1x9gknd 4209 14 this this DT cord-010119-t1x9gknd 4209 15 BC BC NNP cord-010119-t1x9gknd 4209 16 is be VBZ cord-010119-t1x9gknd 4209 17 not not RB cord-010119-t1x9gknd 4209 18 known know VBN cord-010119-t1x9gknd 4209 19 . . . cord-010119-t1x9gknd 4210 1 The the DT cord-010119-t1x9gknd 4210 2 aim aim NN cord-010119-t1x9gknd 4210 3 of of IN cord-010119-t1x9gknd 4210 4 the the DT cord-010119-t1x9gknd 4210 5 study study NN cord-010119-t1x9gknd 4210 6 was be VBD cord-010119-t1x9gknd 4210 7 to to TO cord-010119-t1x9gknd 4210 8 investigate investigate VB cord-010119-t1x9gknd 4210 9 the the DT cord-010119-t1x9gknd 4210 10 in in FW cord-010119-t1x9gknd 4210 11 vitro vitro FW cord-010119-t1x9gknd 4210 12 quality quality NN cord-010119-t1x9gknd 4210 13 of of IN cord-010119-t1x9gknd 4210 14 PC pc NN cord-010119-t1x9gknd 4210 15 prepared prepare VBN cord-010119-t1x9gknd 4210 16 from from IN cord-010119-t1x9gknd 4210 17 NSAID NSAID NNP cord-010119-t1x9gknd 4210 18 - - HYPH cord-010119-t1x9gknd 4210 19 BC BC NNP cord-010119-t1x9gknd 4210 20 and and CC cord-010119-t1x9gknd 4210 21 autologous autologous JJ cord-010119-t1x9gknd 4210 22 plasma plasma NN cord-010119-t1x9gknd 4210 23 during during IN cord-010119-t1x9gknd 4210 24 storage storage NN cord-010119-t1x9gknd 4210 25 . . . cord-010119-t1x9gknd 4211 1 Study Study NNP cord-010119-t1x9gknd 4211 2 Design Design NNP cord-010119-t1x9gknd 4211 3 / / SYM cord-010119-t1x9gknd 4211 4 Method method NN cord-010119-t1x9gknd 4211 5 : : : cord-010119-t1x9gknd 4212 1 Single single JJ cord-010119-t1x9gknd 4212 2 - - HYPH cord-010119-t1x9gknd 4212 3 donor donor NN cord-010119-t1x9gknd 4212 4 PC pc NN cord-010119-t1x9gknd 4212 5 ( ( -LRB- cord-010119-t1x9gknd 4212 6 sPC spc XX cord-010119-t1x9gknd 4212 7 , , , cord-010119-t1x9gknd 4212 8 n518 n518 NN cord-010119-t1x9gknd 4212 9 ) ) -RRB- cord-010119-t1x9gknd 4212 10 were be VBD cord-010119-t1x9gknd 4212 11 prepared prepare VBN cord-010119-t1x9gknd 4212 12 from from IN cord-010119-t1x9gknd 4212 13 a a DT cord-010119-t1x9gknd 4212 14 NSAID NSAID NNP cord-010119-t1x9gknd 4212 15 - - HYPH cord-010119-t1x9gknd 4212 16 BC BC NNP cord-010119-t1x9gknd 4212 17 and and CC cord-010119-t1x9gknd 4212 18 60 60 CD cord-010119-t1x9gknd 4212 19 mL ml NN cord-010119-t1x9gknd 4212 20 of of IN cord-010119-t1x9gknd 4212 21 autologous autologous JJ cord-010119-t1x9gknd 4212 22 plasma plasma NN cord-010119-t1x9gknd 4212 23 . . . cord-010119-t1x9gknd 4213 1 Information information NN cord-010119-t1x9gknd 4213 2 about about IN cord-010119-t1x9gknd 4213 3 the the DT cord-010119-t1x9gknd 4213 4 type type NN cord-010119-t1x9gknd 4213 5 of of IN cord-010119-t1x9gknd 4213 6 pain pain NN cord-010119-t1x9gknd 4213 7 medication medication NN cord-010119-t1x9gknd 4213 8 was be VBD cord-010119-t1x9gknd 4213 9 extracted extract VBN cord-010119-t1x9gknd 4213 10 from from IN cord-010119-t1x9gknd 4213 11 the the DT cord-010119-t1x9gknd 4213 12 anamneses anamneses NNP cord-010119-t1x9gknd 4213 13 form form NN cord-010119-t1x9gknd 4213 14 . . . cord-010119-t1x9gknd 4214 1 The the DT cord-010119-t1x9gknd 4214 2 sPC sPC NNS cord-010119-t1x9gknd 4214 3 were be VBD cord-010119-t1x9gknd 4214 4 stored store VBN cord-010119-t1x9gknd 4214 5 for for IN cord-010119-t1x9gknd 4214 6 8 8 CD cord-010119-t1x9gknd 4214 7 days day NNS cord-010119-t1x9gknd 4214 8 at at IN cord-010119-t1x9gknd 4214 9 22 22 CD cord-010119-t1x9gknd 4214 10 6 6 CD cord-010119-t1x9gknd 4214 11 28C 28C NNS cord-010119-t1x9gknd 4214 12 and and CC cord-010119-t1x9gknd 4214 13 sampled sample VBN cord-010119-t1x9gknd 4214 14 at at IN cord-010119-t1x9gknd 4214 15 regular regular JJ cord-010119-t1x9gknd 4214 16 intervals interval NNS cord-010119-t1x9gknd 4214 17 . . . cord-010119-t1x9gknd 4215 1 Aggregation aggregation NN cord-010119-t1x9gknd 4215 2 tests test NNS cord-010119-t1x9gknd 4215 3 were be VBD cord-010119-t1x9gknd 4215 4 performed perform VBN cord-010119-t1x9gknd 4215 5 with with IN cord-010119-t1x9gknd 4215 6 Chronolog Chronolog NNP cord-010119-t1x9gknd 4215 7 ( ( -LRB- cord-010119-t1x9gknd 4215 8 ADP ADP NNP cord-010119-t1x9gknd 4215 9 or or CC cord-010119-t1x9gknd 4215 10 collagen collagen NN cord-010119-t1x9gknd 4215 11 ) ) -RRB- cord-010119-t1x9gknd 4215 12 and and CC cord-010119-t1x9gknd 4215 13 Multiplate Multiplate NNP cord-010119-t1x9gknd 4215 14 ( ( -LRB- cord-010119-t1x9gknd 4215 15 arachidonic arachidonic JJ cord-010119-t1x9gknd 4215 16 acid acid NN cord-010119-t1x9gknd 4215 17 ) ) -RRB- cord-010119-t1x9gknd 4215 18 aggregometers aggregometer NNS cord-010119-t1x9gknd 4215 19 . . . cord-010119-t1x9gknd 4216 1 Thromboelastography Thromboelastography NNP cord-010119-t1x9gknd 4216 2 ( ( -LRB- cord-010119-t1x9gknd 4216 3 TEG TEG NNP cord-010119-t1x9gknd 4216 4 , , , cord-010119-t1x9gknd 4216 5 kaolin kaolin NN cord-010119-t1x9gknd 4216 6 ) ) -RRB- cord-010119-t1x9gknd 4216 7 was be VBD cord-010119-t1x9gknd 4216 8 applied apply VBN cord-010119-t1x9gknd 4216 9 for for IN cord-010119-t1x9gknd 4216 10 assessment assessment NN cord-010119-t1x9gknd 4216 11 of of IN cord-010119-t1x9gknd 4216 12 the the DT cord-010119-t1x9gknd 4216 13 overall overall JJ cord-010119-t1x9gknd 4216 14 clotting clotting NN cord-010119-t1x9gknd 4216 15 capacity capacity NN cord-010119-t1x9gknd 4216 16 . . . cord-010119-t1x9gknd 4216 17 sPC sPC NNS cord-010119-t1x9gknd 4216 18 in in IN cord-010119-t1x9gknd 4216 19 plasma plasma NN cord-010119-t1x9gknd 4216 20 from from IN cord-010119-t1x9gknd 4216 21 normal normal JJ cord-010119-t1x9gknd 4216 22 controls control NNS cord-010119-t1x9gknd 4216 23 ( ( -LRB- cord-010119-t1x9gknd 4216 24 n55 n55 NNP cord-010119-t1x9gknd 4216 25 ) ) -RRB- cord-010119-t1x9gknd 4216 26 were be VBD cord-010119-t1x9gknd 4216 27 investigated investigate VBN cord-010119-t1x9gknd 4216 28 as as IN cord-010119-t1x9gknd 4216 29 a a DT cord-010119-t1x9gknd 4216 30 reference reference NN cord-010119-t1x9gknd 4216 31 . . . cord-010119-t1x9gknd 4217 1 Values value NNS cord-010119-t1x9gknd 4217 2 are be VBP cord-010119-t1x9gknd 4217 3 expressed express VBN cord-010119-t1x9gknd 4217 4 as as IN cord-010119-t1x9gknd 4217 5 mean6SD mean6sd NN cord-010119-t1x9gknd 4217 6 or or CC cord-010119-t1x9gknd 4217 7 as as IN cord-010119-t1x9gknd 4217 8 median median NN cord-010119-t1x9gknd 4217 9 & & CC cord-010119-t1x9gknd 4217 10 IQR IQR NNP cord-010119-t1x9gknd 4217 11 . . . cord-010119-t1x9gknd 4218 1 A a DT cord-010119-t1x9gknd 4218 2 non non JJ cord-010119-t1x9gknd 4218 3 - - JJ cord-010119-t1x9gknd 4218 4 paired paired JJ cord-010119-t1x9gknd 4218 5 t t NN cord-010119-t1x9gknd 4218 6 - - HYPH cord-010119-t1x9gknd 4218 7 test test NN cord-010119-t1x9gknd 4218 8 or or CC cord-010119-t1x9gknd 4218 9 a a DT cord-010119-t1x9gknd 4218 10 Mann Mann NNP cord-010119-t1x9gknd 4218 11 - - HYPH cord-010119-t1x9gknd 4218 12 Whitney Whitney NNP cord-010119-t1x9gknd 4218 13 U U NNP cord-010119-t1x9gknd 4218 14 test test NN cord-010119-t1x9gknd 4218 15 was be VBD cord-010119-t1x9gknd 4218 16 applied apply VBN cord-010119-t1x9gknd 4218 17 for for IN cord-010119-t1x9gknd 4218 18 statistical statistical JJ cord-010119-t1x9gknd 4218 19 analyses analysis NNS cord-010119-t1x9gknd 4218 20 of of IN cord-010119-t1x9gknd 4218 21 normal normal JJ cord-010119-t1x9gknd 4218 22 or or CC cord-010119-t1x9gknd 4218 23 nonnormal nonnormal NN cord-010119-t1x9gknd 4218 24 distributed distribute VBN cord-010119-t1x9gknd 4218 25 data datum NNS cord-010119-t1x9gknd 4218 26 respectively respectively RB cord-010119-t1x9gknd 4218 27 . . . cord-010119-t1x9gknd 4219 1 Results/ Results/ . cord-010119-t1x9gknd 4220 1 Finding finding NN cord-010119-t1x9gknd 4220 2 : : : cord-010119-t1x9gknd 4221 1 Volume volume NN cord-010119-t1x9gknd 4221 2 ( ( -LRB- cord-010119-t1x9gknd 4221 3 69 69 CD cord-010119-t1x9gknd 4221 4 6 6 CD cord-010119-t1x9gknd 4221 5 4 4 CD cord-010119-t1x9gknd 4221 6 vs. vs. IN cord-010119-t1x9gknd 4221 7 66 66 CD cord-010119-t1x9gknd 4221 8 6 6 CD cord-010119-t1x9gknd 4221 9 16 16 CD cord-010119-t1x9gknd 4221 10 mL ml NN cord-010119-t1x9gknd 4221 11 ) ) -RRB- cord-010119-t1x9gknd 4221 12 and and CC cord-010119-t1x9gknd 4221 13 PLT PLT NNP cord-010119-t1x9gknd 4221 14 content content NN cord-010119-t1x9gknd 4221 15 ( ( -LRB- cord-010119-t1x9gknd 4221 16 67 67 CD cord-010119-t1x9gknd 4221 17 6 6 CD cord-010119-t1x9gknd 4221 18 14 14 CD cord-010119-t1x9gknd 4221 19 vs. vs. NN cord-010119-t1x9gknd 4221 20 71 71 CD cord-010119-t1x9gknd 4221 21 6 6 CD cord-010119-t1x9gknd 4221 22 15x10 15x10 CD cord-010119-t1x9gknd 4221 23 9 9 CD cord-010119-t1x9gknd 4221 24 ) ) -RRB- cord-010119-t1x9gknd 4221 25 were be VBD cord-010119-t1x9gknd 4221 26 similar similar JJ cord-010119-t1x9gknd 4221 27 in in IN cord-010119-t1x9gknd 4221 28 both both DT cord-010119-t1x9gknd 4221 29 groups group NNS cord-010119-t1x9gknd 4221 30 . . . cord-010119-t1x9gknd 4222 1 On on IN cord-010119-t1x9gknd 4222 2 Day Day NNP cord-010119-t1x9gknd 4222 3 8 8 CD cord-010119-t1x9gknd 4222 4 , , , cord-010119-t1x9gknd 4222 5 both both DT cord-010119-t1x9gknd 4222 6 groups group NNS cord-010119-t1x9gknd 4222 7 showed show VBD cord-010119-t1x9gknd 4222 8 comparable comparable JJ cord-010119-t1x9gknd 4222 9 pH ph NN cord-010119-t1x9gknd 4222 10 and and CC cord-010119-t1x9gknd 4222 11 changes change NNS cord-010119-t1x9gknd 4222 12 in in IN cord-010119-t1x9gknd 4222 13 PLT PLT NNP cord-010119-t1x9gknd 4222 14 content content NN cord-010119-t1x9gknd 4222 15 ( ( -LRB- cord-010119-t1x9gknd 4222 16 data datum NNS cord-010119-t1x9gknd 4222 17 not not RB cord-010119-t1x9gknd 4222 18 shown show VBN cord-010119-t1x9gknd 4222 19 ) ) -RRB- cord-010119-t1x9gknd 4222 20 . . . cord-010119-t1x9gknd 4223 1 Phosphatidylserine phosphatidylserine NN cord-010119-t1x9gknd 4223 2 exposure exposure NN cord-010119-t1x9gknd 4223 3 on on IN cord-010119-t1x9gknd 4223 4 Day day NN cord-010119-t1x9gknd 4223 5 8 8 CD cord-010119-t1x9gknd 4223 6 was be VBD cord-010119-t1x9gknd 4223 7 significant significant JJ cord-010119-t1x9gknd 4223 8 higher high JJR cord-010119-t1x9gknd 4223 9 in in IN cord-010119-t1x9gknd 4223 10 a a DT cord-010119-t1x9gknd 4223 11 subset subset NN cord-010119-t1x9gknd 4223 12 of of IN cord-010119-t1x9gknd 4223 13 donors donor NNS cord-010119-t1x9gknd 4223 14 who who WP cord-010119-t1x9gknd 4223 15 had have VBD cord-010119-t1x9gknd 4223 16 used use VBN cord-010119-t1x9gknd 4223 17 ibuprofen ibuprofen NN cord-010119-t1x9gknd 4223 18 ( ( -LRB- cord-010119-t1x9gknd 4223 19 n55 n55 NNP cord-010119-t1x9gknd 4223 20 ) ) -RRB- cord-010119-t1x9gknd 4223 21 . . . cord-010119-t1x9gknd 4224 1 Aggregation aggregation NN cord-010119-t1x9gknd 4224 2 tests test NNS cord-010119-t1x9gknd 4224 3 with with IN cord-010119-t1x9gknd 4224 4 arachidonic arachidonic JJ cord-010119-t1x9gknd 4224 5 acid acid NN cord-010119-t1x9gknd 4224 6 revealed reveal VBN cord-010119-t1x9gknd 4224 7 in in IN cord-010119-t1x9gknd 4224 8 general general JJ cord-010119-t1x9gknd 4224 9 a a DT cord-010119-t1x9gknd 4224 10 low low JJ cord-010119-t1x9gknd 4224 11 or or CC cord-010119-t1x9gknd 4224 12 absent absent JJ cord-010119-t1x9gknd 4224 13 response response NN cord-010119-t1x9gknd 4224 14 for for IN cord-010119-t1x9gknd 4224 15 sPC sPC NNS cord-010119-t1x9gknd 4224 16 with with IN cord-010119-t1x9gknd 4224 17 aspirin aspirin NN cord-010119-t1x9gknd 4224 18 ( ( -LRB- cord-010119-t1x9gknd 4224 19 0,0 0,0 CD cord-010119-t1x9gknd 4224 20 - - SYM cord-010119-t1x9gknd 4224 21 30 30 CD cord-010119-t1x9gknd 4224 22 , , , cord-010119-t1x9gknd 4224 23 p<0.05 p<0.05 CD cord-010119-t1x9gknd 4224 24 ) ) -RRB- cord-010119-t1x9gknd 4224 25 , , , cord-010119-t1x9gknd 4224 26 diclofenac diclofenac NNP cord-010119-t1x9gknd 4224 27 ( ( -LRB- cord-010119-t1x9gknd 4224 28 31,1 31,1 CD cord-010119-t1x9gknd 4224 29 - - SYM cord-010119-t1x9gknd 4224 30 76 76 CD cord-010119-t1x9gknd 4224 31 ) ) -RRB- cord-010119-t1x9gknd 4224 32 and and CC cord-010119-t1x9gknd 4224 33 naproxen naproxen NN cord-010119-t1x9gknd 4224 34 ( ( -LRB- cord-010119-t1x9gknd 4224 35 0,0 0,0 CD cord-010119-t1x9gknd 4224 36 - - SYM cord-010119-t1x9gknd 4224 37 24 24 CD cord-010119-t1x9gknd 4224 38 , , , cord-010119-t1x9gknd 4224 39 p<0.05 p<0.05 CD cord-010119-t1x9gknd 4224 40 ) ) -RRB- cord-010119-t1x9gknd 4224 41 , , , cord-010119-t1x9gknd 4224 42 compared compare VBN cord-010119-t1x9gknd 4224 43 to to IN cord-010119-t1x9gknd 4224 44 normal normal JJ cord-010119-t1x9gknd 4224 45 controls control NNS cord-010119-t1x9gknd 4224 46 ( ( -LRB- cord-010119-t1x9gknd 4224 47 76 76 CD cord-010119-t1x9gknd 4224 48 , , , cord-010119-t1x9gknd 4224 49 . . . cord-010119-t1x9gknd 4225 1 No no DT cord-010119-t1x9gknd 4225 2 differences difference NNS cord-010119-t1x9gknd 4225 3 were be VBD cord-010119-t1x9gknd 4225 4 detected detect VBN cord-010119-t1x9gknd 4225 5 in in IN cord-010119-t1x9gknd 4225 6 aggregation aggregation NN cord-010119-t1x9gknd 4225 7 with with IN cord-010119-t1x9gknd 4225 8 ADP ADP NNP cord-010119-t1x9gknd 4225 9 or or CC cord-010119-t1x9gknd 4225 10 collagen collagen NN cord-010119-t1x9gknd 4225 11 . . . cord-010119-t1x9gknd 4226 1 With with IN cord-010119-t1x9gknd 4226 2 TEG TEG NNP cord-010119-t1x9gknd 4226 3 , , , cord-010119-t1x9gknd 4226 4 slightly slightly RB cord-010119-t1x9gknd 4226 5 longer long RBR cord-010119-t1x9gknd 4226 6 R r NN cord-010119-t1x9gknd 4226 7 - - HYPH cord-010119-t1x9gknd 4226 8 times time NNS cord-010119-t1x9gknd 4226 9 ( ( -LRB- cord-010119-t1x9gknd 4226 10 initiation initiation NN cord-010119-t1x9gknd 4226 11 phase phase NN cord-010119-t1x9gknd 4226 12 ) ) -RRB- cord-010119-t1x9gknd 4226 13 were be VBD cord-010119-t1x9gknd 4226 14 measured measure VBN cord-010119-t1x9gknd 4226 15 on on IN cord-010119-t1x9gknd 4226 16 Day Day NNP cord-010119-t1x9gknd 4226 17 1 1 CD cord-010119-t1x9gknd 4226 18 in in IN cord-010119-t1x9gknd 4226 19 sPC spc NN cord-010119-t1x9gknd 4226 20 with with IN cord-010119-t1x9gknd 4226 21 aspirin aspirin NN cord-010119-t1x9gknd 4226 22 , , , cord-010119-t1x9gknd 4226 23 diclofenac diclofenac NNP cord-010119-t1x9gknd 4226 24 and and CC cord-010119-t1x9gknd 4226 25 naproxen naproxen NN cord-010119-t1x9gknd 4226 26 , , , cord-010119-t1x9gknd 4226 27 compared compare VBN cord-010119-t1x9gknd 4226 28 to to IN cord-010119-t1x9gknd 4226 29 the the DT cord-010119-t1x9gknd 4226 30 normal normal JJ cord-010119-t1x9gknd 4226 31 controls control NNS cord-010119-t1x9gknd 4226 32 ( ( -LRB- cord-010119-t1x9gknd 4226 33 only only RB cord-010119-t1x9gknd 4226 34 significant significant JJ cord-010119-t1x9gknd 4226 35 for for IN cord-010119-t1x9gknd 4226 36 naproxen naproxen NN cord-010119-t1x9gknd 4226 37 ) ) -RRB- cord-010119-t1x9gknd 4226 38 . . . cord-010119-t1x9gknd 4227 1 These these DT cord-010119-t1x9gknd 4227 2 differences difference NNS cord-010119-t1x9gknd 4227 3 disappeared disappear VBD cord-010119-t1x9gknd 4227 4 during during IN cord-010119-t1x9gknd 4227 5 storage storage NN cord-010119-t1x9gknd 4227 6 . . . cord-010119-t1x9gknd 4228 1 Conclusion conclusion NN cord-010119-t1x9gknd 4228 2 : : : cord-010119-t1x9gknd 4228 3 Storage storage NN cord-010119-t1x9gknd 4228 4 properties property NNS cord-010119-t1x9gknd 4228 5 of of IN cord-010119-t1x9gknd 4228 6 sPC sPC NNS cord-010119-t1x9gknd 4228 7 prepared prepare VBN cord-010119-t1x9gknd 4228 8 from from IN cord-010119-t1x9gknd 4228 9 NSAID NSAID NNP cord-010119-t1x9gknd 4228 10 - - HYPH cord-010119-t1x9gknd 4228 11 BC BC NNP cord-010119-t1x9gknd 4228 12 were be VBD cord-010119-t1x9gknd 4228 13 comparable comparable JJ cord-010119-t1x9gknd 4228 14 with with IN cord-010119-t1x9gknd 4228 15 sPC sPC NNS cord-010119-t1x9gknd 4228 16 from from IN cord-010119-t1x9gknd 4228 17 normal normal JJ cord-010119-t1x9gknd 4228 18 controls control NNS cord-010119-t1x9gknd 4228 19 . . . cord-010119-t1x9gknd 4229 1 Main main JJ cord-010119-t1x9gknd 4229 2 differences difference NNS cord-010119-t1x9gknd 4229 3 were be VBD cord-010119-t1x9gknd 4229 4 observed observe VBN cord-010119-t1x9gknd 4229 5 in in IN cord-010119-t1x9gknd 4229 6 aggregation aggregation NN cord-010119-t1x9gknd 4229 7 and and CC cord-010119-t1x9gknd 4229 8 coagulation coagulation NN cord-010119-t1x9gknd 4229 9 properties property NNS cord-010119-t1x9gknd 4229 10 for for IN cord-010119-t1x9gknd 4229 11 donors donor NNS cord-010119-t1x9gknd 4229 12 who who WP cord-010119-t1x9gknd 4229 13 used use VBD cord-010119-t1x9gknd 4229 14 aspirin aspirin NN cord-010119-t1x9gknd 4229 15 , , , cord-010119-t1x9gknd 4229 16 diclofenac diclofenac NNP cord-010119-t1x9gknd 4229 17 or or CC cord-010119-t1x9gknd 4229 18 naproxen naproxen NN cord-010119-t1x9gknd 4229 19 . . . cord-010119-t1x9gknd 4230 1 PLT PLT NNP cord-010119-t1x9gknd 4230 2 from from IN cord-010119-t1x9gknd 4230 3 donors donor NNS cord-010119-t1x9gknd 4230 4 who who WP cord-010119-t1x9gknd 4230 5 used use VBD cord-010119-t1x9gknd 4230 6 ibuprofen ibuprofen NN cord-010119-t1x9gknd 4230 7 showed show VBD cord-010119-t1x9gknd 4230 8 little little JJ cord-010119-t1x9gknd 4230 9 or or CC cord-010119-t1x9gknd 4230 10 no no DT cord-010119-t1x9gknd 4230 11 deviations deviation NNS cord-010119-t1x9gknd 4230 12 . . . cord-010119-t1x9gknd 4231 1 This this DT cord-010119-t1x9gknd 4231 2 is be VBZ cord-010119-t1x9gknd 4231 3 most most RBS cord-010119-t1x9gknd 4231 4 likely likely RB cord-010119-t1x9gknd 4231 5 caused cause VBN cord-010119-t1x9gknd 4231 6 by by IN cord-010119-t1x9gknd 4231 7 the the DT cord-010119-t1x9gknd 4231 8 fast fast JJ cord-010119-t1x9gknd 4231 9 ( ( -LRB- cord-010119-t1x9gknd 4231 10 < < XX cord-010119-t1x9gknd 4231 11 24 24 CD cord-010119-t1x9gknd 4231 12 hour hour NN cord-010119-t1x9gknd 4231 13 ) ) -RRB- cord-010119-t1x9gknd 4231 14 disappearance disappearance NN cord-010119-t1x9gknd 4231 15 of of IN cord-010119-t1x9gknd 4231 16 ibuprofen ibuprofen NN cord-010119-t1x9gknd 4231 17 from from IN cord-010119-t1x9gknd 4231 18 the the DT cord-010119-t1x9gknd 4231 19 blood blood NN cord-010119-t1x9gknd 4231 20 circulation circulation NN cord-010119-t1x9gknd 4231 21 and and CC cord-010119-t1x9gknd 4231 22 the the DT cord-010119-t1x9gknd 4231 23 reversible reversible JJ cord-010119-t1x9gknd 4231 24 binding binding NN cord-010119-t1x9gknd 4231 25 to to IN cord-010119-t1x9gknd 4231 26 PLT PLT NNP cord-010119-t1x9gknd 4231 27 . . . cord-010119-t1x9gknd 4232 1 The the DT cord-010119-t1x9gknd 4232 2 use use NN cord-010119-t1x9gknd 4232 3 of of IN cord-010119-t1x9gknd 4232 4 BC BC NNP cord-010119-t1x9gknd 4232 5 from from IN cord-010119-t1x9gknd 4232 6 donors donor NNS cord-010119-t1x9gknd 4232 7 who who WP cord-010119-t1x9gknd 4232 8 used use VBD cord-010119-t1x9gknd 4232 9 ibuprofen ibuprofen NN cord-010119-t1x9gknd 4232 10 will will MD cord-010119-t1x9gknd 4232 11 be be VB cord-010119-t1x9gknd 4232 12 further further RB cord-010119-t1x9gknd 4232 13 investigated investigate VBN cord-010119-t1x9gknd 4232 14 in in IN cord-010119-t1x9gknd 4232 15 a a DT cord-010119-t1x9gknd 4232 16 ' ' `` cord-010119-t1x9gknd 4232 17 worst bad JJS cord-010119-t1x9gknd 4232 18 case case NN cord-010119-t1x9gknd 4232 19 ' ' '' cord-010119-t1x9gknd 4232 20 ( ( -LRB- cord-010119-t1x9gknd 4232 21 PC pc NN cord-010119-t1x9gknd 4232 22 in in IN cord-010119-t1x9gknd 4232 23 plasma plasma NN cord-010119-t1x9gknd 4232 24 ) ) -RRB- cord-010119-t1x9gknd 4232 25 and and CC cord-010119-t1x9gknd 4232 26 ' ' `` cord-010119-t1x9gknd 4232 27 best good JJS cord-010119-t1x9gknd 4232 28 case case NN cord-010119-t1x9gknd 4232 29 ' ' '' cord-010119-t1x9gknd 4232 30 ( ( -LRB- cord-010119-t1x9gknd 4232 31 PC pc NN cord-010119-t1x9gknd 4232 32 in in IN cord-010119-t1x9gknd 4232 33 additive additive NN cord-010119-t1x9gknd 4232 34 solution solution NN cord-010119-t1x9gknd 4232 35 ) ) -RRB- cord-010119-t1x9gknd 4232 36 scenario scenario NN cord-010119-t1x9gknd 4232 37 . . . cord-010119-t1x9gknd 4233 1 The the DT cord-010119-t1x9gknd 4233 2 effects effect NNS cord-010119-t1x9gknd 4233 3 of of IN cord-010119-t1x9gknd 4233 4 ibuprofen ibuprofen NN cord-010119-t1x9gknd 4233 5 on on IN cord-010119-t1x9gknd 4233 6 aggregation aggregation NN cord-010119-t1x9gknd 4233 7 and and CC cord-010119-t1x9gknd 4233 8 coagulation coagulation NN cord-010119-t1x9gknd 4233 9 properties property NNS cord-010119-t1x9gknd 4233 10 will will MD cord-010119-t1x9gknd 4233 11 be be VB cord-010119-t1x9gknd 4233 12 further further RB cord-010119-t1x9gknd 4233 13 investigated investigate VBN cord-010119-t1x9gknd 4233 14 in in IN cord-010119-t1x9gknd 4233 15 a a DT cord-010119-t1x9gknd 4233 16 dose dose JJ cord-010119-t1x9gknd 4233 17 - - HYPH cord-010119-t1x9gknd 4233 18 response response NN cord-010119-t1x9gknd 4233 19 study study NN cord-010119-t1x9gknd 4233 20 design design NN cord-010119-t1x9gknd 4233 21 adding add VBG cord-010119-t1x9gknd 4233 22 different different JJ cord-010119-t1x9gknd 4233 23 levels level NNS cord-010119-t1x9gknd 4233 24 of of IN cord-010119-t1x9gknd 4233 25 ibuprofen ibuprofen NN cord-010119-t1x9gknd 4233 26 to to IN cord-010119-t1x9gknd 4233 27 PLT PLT NNP cord-010119-t1x9gknd 4233 28 . . . cord-010119-t1x9gknd 4234 1 Background Background NNP cord-010119-t1x9gknd 4234 2 / / SYM cord-010119-t1x9gknd 4234 3 Case Case NNP cord-010119-t1x9gknd 4234 4 Studies Studies NNPS cord-010119-t1x9gknd 4234 5 : : : cord-010119-t1x9gknd 4234 6 Previously previously RB cord-010119-t1x9gknd 4234 7 it -PRON- PRP cord-010119-t1x9gknd 4234 8 was be VBD cord-010119-t1x9gknd 4234 9 shown show VBN cord-010119-t1x9gknd 4234 10 that that IN cord-010119-t1x9gknd 4234 11 donors donor NNS cord-010119-t1x9gknd 4234 12 could could MD cord-010119-t1x9gknd 4234 13 be be VB cord-010119-t1x9gknd 4234 14 classified classify VBN cord-010119-t1x9gknd 4234 15 as as IN cord-010119-t1x9gknd 4234 16 having have VBG cord-010119-t1x9gknd 4234 17 platelets platelet NNS cord-010119-t1x9gknd 4234 18 ( ( -LRB- cord-010119-t1x9gknd 4234 19 PLT PLT NNP cord-010119-t1x9gknd 4234 20 ) ) -RRB- cord-010119-t1x9gknd 4234 21 with with IN cord-010119-t1x9gknd 4234 22 good good JJ cord-010119-t1x9gknd 4234 23 , , , cord-010119-t1x9gknd 4234 24 average average JJ cord-010119-t1x9gknd 4234 25 or or CC cord-010119-t1x9gknd 4234 26 poor poor JJ cord-010119-t1x9gknd 4234 27 storage storage NN cord-010119-t1x9gknd 4234 28 properties property NNS cord-010119-t1x9gknd 4234 29 [ [ -LRB- cord-010119-t1x9gknd 4234 30 Bontekoe Bontekoe NNP cord-010119-t1x9gknd 4234 31 , , , cord-010119-t1x9gknd 4234 32 Transfusion Transfusion NNP cord-010119-t1x9gknd 4234 33 , , , cord-010119-t1x9gknd 4234 34 2014 2014 CD cord-010119-t1x9gknd 4234 35 ] ] -RRB- cord-010119-t1x9gknd 4234 36 . . . cord-010119-t1x9gknd 4235 1 A a DT cord-010119-t1x9gknd 4235 2 main main JJ cord-010119-t1x9gknd 4235 3 difference difference NN cord-010119-t1x9gknd 4235 4 between between IN cord-010119-t1x9gknd 4235 5 ' ' `` cord-010119-t1x9gknd 4235 6 good good JJ cord-010119-t1x9gknd 4235 7 ' ' '' cord-010119-t1x9gknd 4235 8 and and CC cord-010119-t1x9gknd 4235 9 ' ' `` cord-010119-t1x9gknd 4235 10 poor poor JJ cord-010119-t1x9gknd 4235 11 ' ' '' cord-010119-t1x9gknd 4235 12 storage storage NN cord-010119-t1x9gknd 4235 13 properties property NNS cord-010119-t1x9gknd 4235 14 involved involve VBD cord-010119-t1x9gknd 4235 15 metabolic metabolic JJ cord-010119-t1x9gknd 4235 16 activity activity NN cord-010119-t1x9gknd 4235 17 , , , cord-010119-t1x9gknd 4235 18 resulting result VBG cord-010119-t1x9gknd 4235 19 in in IN cord-010119-t1x9gknd 4235 20 a a DT cord-010119-t1x9gknd 4235 21 faster fast JJR cord-010119-t1x9gknd 4235 22 decline decline NN cord-010119-t1x9gknd 4235 23 of of IN cord-010119-t1x9gknd 4235 24 pH ph NN cord-010119-t1x9gknd 4235 25 during during IN cord-010119-t1x9gknd 4235 26 storage storage NN cord-010119-t1x9gknd 4235 27 of of IN cord-010119-t1x9gknd 4235 28 ' ' `` cord-010119-t1x9gknd 4235 29 poor poor JJ cord-010119-t1x9gknd 4235 30 ' ' '' cord-010119-t1x9gknd 4235 31 PLT PLT NNP cord-010119-t1x9gknd 4235 32 concentrates concentrate VBZ cord-010119-t1x9gknd 4235 33 ( ( -LRB- cord-010119-t1x9gknd 4235 34 PC pc NN cord-010119-t1x9gknd 4235 35 ) ) -RRB- cord-010119-t1x9gknd 4235 36 . . . cord-010119-t1x9gknd 4236 1 This this DT cord-010119-t1x9gknd 4236 2 might may MD cord-010119-t1x9gknd 4236 3 be be VB cord-010119-t1x9gknd 4236 4 caused cause VBN cord-010119-t1x9gknd 4236 5 by by IN cord-010119-t1x9gknd 4236 6 a a DT cord-010119-t1x9gknd 4236 7 different different JJ cord-010119-t1x9gknd 4236 8 functionality functionality NN cord-010119-t1x9gknd 4236 9 of of IN cord-010119-t1x9gknd 4236 10 the the DT cord-010119-t1x9gknd 4236 11 PLT PLT NNP cord-010119-t1x9gknd 4236 12 mitochondria mitochondrion NNS cord-010119-t1x9gknd 4236 13 and and CC cord-010119-t1x9gknd 4236 14 there there EX cord-010119-t1x9gknd 4236 15 are be VBP cord-010119-t1x9gknd 4236 16 indications indication NNS cord-010119-t1x9gknd 4236 17 that that IN cord-010119-t1x9gknd 4236 18 donors donor NNS cord-010119-t1x9gknd 4236 19 with with IN cord-010119-t1x9gknd 4236 20 a a DT cord-010119-t1x9gknd 4236 21 history history NN cord-010119-t1x9gknd 4236 22 of of IN cord-010119-t1x9gknd 4236 23 ' ' `` cord-010119-t1x9gknd 4236 24 poor poor JJ cord-010119-t1x9gknd 4236 25 ' ' '' cord-010119-t1x9gknd 4236 26 PCs pc NNS cord-010119-t1x9gknd 4236 27 are be VBP cord-010119-t1x9gknd 4236 28 more more RBR cord-010119-t1x9gknd 4236 29 likely likely JJ cord-010119-t1x9gknd 4236 30 to to TO cord-010119-t1x9gknd 4236 31 have have VB cord-010119-t1x9gknd 4236 32 health health NN cord-010119-t1x9gknd 4236 33 issues issue NNS cord-010119-t1x9gknd 4236 34 , , , cord-010119-t1x9gknd 4236 35 pointing point VBG cord-010119-t1x9gknd 4236 36 towards towards IN cord-010119-t1x9gknd 4236 37 Metabolic Metabolic NNP cord-010119-t1x9gknd 4236 38 Syndrome Syndrome NNP cord-010119-t1x9gknd 4236 39 and and CC cord-010119-t1x9gknd 4236 40 Type Type NNP cord-010119-t1x9gknd 4236 41 2 2 CD cord-010119-t1x9gknd 4236 42 diabetes diabetes NN cord-010119-t1x9gknd 4236 43 ( ( -LRB- cord-010119-t1x9gknd 4236 44 T2D t2d CD cord-010119-t1x9gknd 4236 45 ) ) -RRB- cord-010119-t1x9gknd 4236 46 . . . cord-010119-t1x9gknd 4237 1 Because because IN cord-010119-t1x9gknd 4237 2 of of IN cord-010119-t1x9gknd 4237 3 the the DT cord-010119-t1x9gknd 4237 4 strong strong JJ cord-010119-t1x9gknd 4237 5 rise rise NN cord-010119-t1x9gknd 4237 6 of of IN cord-010119-t1x9gknd 4237 7 people people NNS cord-010119-t1x9gknd 4237 8 with with IN cord-010119-t1x9gknd 4237 9 T2D t2d CD cord-010119-t1x9gknd 4237 10 in in IN cord-010119-t1x9gknd 4237 11 the the DT cord-010119-t1x9gknd 4237 12 Dutch dutch JJ cord-010119-t1x9gknd 4237 13 population population NN cord-010119-t1x9gknd 4237 14 , , , cord-010119-t1x9gknd 4237 15 the the DT cord-010119-t1x9gknd 4237 16 aim aim NN cord-010119-t1x9gknd 4237 17 of of IN cord-010119-t1x9gknd 4237 18 this this DT cord-010119-t1x9gknd 4237 19 study study NN cord-010119-t1x9gknd 4237 20 was be VBD cord-010119-t1x9gknd 4237 21 to to TO cord-010119-t1x9gknd 4237 22 characterize characterize VB cord-010119-t1x9gknd 4237 23 PLT PLT NNP cord-010119-t1x9gknd 4237 24 from from IN cord-010119-t1x9gknd 4237 25 whole whole JJ cord-010119-t1x9gknd 4237 26 blood blood NN cord-010119-t1x9gknd 4237 27 donors donor NNS cord-010119-t1x9gknd 4237 28 diagnosed diagnose VBN cord-010119-t1x9gknd 4237 29 for for IN cord-010119-t1x9gknd 4237 30 T2D t2d CD cord-010119-t1x9gknd 4237 31 , , , cord-010119-t1x9gknd 4237 32 but but CC cord-010119-t1x9gknd 4237 33 accepted accept VBN cord-010119-t1x9gknd 4237 34 as as IN cord-010119-t1x9gknd 4237 35 donor donor NN cord-010119-t1x9gknd 4237 36 . . . cord-010119-t1x9gknd 4238 1 Study Study NNP cord-010119-t1x9gknd 4238 2 Design Design NNP cord-010119-t1x9gknd 4238 3 / / SYM cord-010119-t1x9gknd 4238 4 Method method NN cord-010119-t1x9gknd 4238 5 : : : cord-010119-t1x9gknd 4239 1 Twelve twelve CD cord-010119-t1x9gknd 4239 2 whole whole JJ cord-010119-t1x9gknd 4239 3 blood blood NN cord-010119-t1x9gknd 4239 4 donors donor NNS cord-010119-t1x9gknd 4239 5 with with IN cord-010119-t1x9gknd 4239 6 T2D t2d CD cord-010119-t1x9gknd 4239 7 , , , cord-010119-t1x9gknd 4239 8 not not RB cord-010119-t1x9gknd 4239 9 using use VBG cord-010119-t1x9gknd 4239 10 insulin insulin NN cord-010119-t1x9gknd 4239 11 , , , cord-010119-t1x9gknd 4239 12 were be VBD cord-010119-t1x9gknd 4239 13 selected select VBN cord-010119-t1x9gknd 4239 14 and and CC cord-010119-t1x9gknd 4239 15 buffy buffy NNP cord-010119-t1x9gknd 4239 16 coat coat NNP cord-010119-t1x9gknd 4239 17 ( ( -LRB- cord-010119-t1x9gknd 4239 18 BC BC NNP cord-010119-t1x9gknd 4239 19 ) ) -RRB- cord-010119-t1x9gknd 4239 20 and and CC cord-010119-t1x9gknd 4239 21 plasma plasma NN cord-010119-t1x9gknd 4239 22 were be VBD cord-010119-t1x9gknd 4239 23 , , , cord-010119-t1x9gknd 4239 24 after after IN cord-010119-t1x9gknd 4239 25 overnight overnight JJ cord-010119-t1x9gknd 4239 26 hold hold NN cord-010119-t1x9gknd 4239 27 , , , cord-010119-t1x9gknd 4239 28 used use VBN cord-010119-t1x9gknd 4239 29 for for IN cord-010119-t1x9gknd 4239 30 preparation preparation NN cord-010119-t1x9gknd 4239 31 of of IN cord-010119-t1x9gknd 4239 32 a a DT cord-010119-t1x9gknd 4239 33 single single JJ cord-010119-t1x9gknd 4239 34 - - HYPH cord-010119-t1x9gknd 4239 35 donor donor NN cord-010119-t1x9gknd 4239 36 PC pc NN cord-010119-t1x9gknd 4239 37 ( ( -LRB- cord-010119-t1x9gknd 4239 38 sPC spc XX cord-010119-t1x9gknd 4239 39 ) ) -RRB- cord-010119-t1x9gknd 4239 40 . . . cord-010119-t1x9gknd 4240 1 An an DT cord-010119-t1x9gknd 4240 2 equivalent equivalent JJ cord-010119-t1x9gknd 4240 3 number number NN cord-010119-t1x9gknd 4240 4 of of IN cord-010119-t1x9gknd 4240 5 sPC sPC NNS cord-010119-t1x9gknd 4240 6 was be VBD cord-010119-t1x9gknd 4240 7 prepared prepare VBN cord-010119-t1x9gknd 4240 8 from from IN cord-010119-t1x9gknd 4240 9 age age NN cord-010119-t1x9gknd 4240 10 and and CC cord-010119-t1x9gknd 4240 11 sex sex NN cord-010119-t1x9gknd 4240 12 matched match VBN cord-010119-t1x9gknd 4240 13 control control NN cord-010119-t1x9gknd 4240 14 donors donor NNS cord-010119-t1x9gknd 4240 15 , , , cord-010119-t1x9gknd 4240 16 derived derive VBN cord-010119-t1x9gknd 4240 17 from from IN cord-010119-t1x9gknd 4240 18 the the DT cord-010119-t1x9gknd 4240 19 same same JJ cord-010119-t1x9gknd 4240 20 collection collection NN cord-010119-t1x9gknd 4240 21 sessions session NNS cord-010119-t1x9gknd 4240 22 . . . cord-010119-t1x9gknd 4241 1 sPC sPC NNS cord-010119-t1x9gknd 4241 2 were be VBD cord-010119-t1x9gknd 4241 3 stored store VBN cord-010119-t1x9gknd 4241 4 for for IN cord-010119-t1x9gknd 4241 5 8 8 CD cord-010119-t1x9gknd 4241 6 days day NNS cord-010119-t1x9gknd 4241 7 at at IN cord-010119-t1x9gknd 4241 8 22 22 CD cord-010119-t1x9gknd 4241 9 6 6 CD cord-010119-t1x9gknd 4241 10 28C 28C NNS cord-010119-t1x9gknd 4241 11 and and CC cord-010119-t1x9gknd 4241 12 sampled sample VBN cord-010119-t1x9gknd 4241 13 on on IN cord-010119-t1x9gknd 4241 14 Day Day NNP cord-010119-t1x9gknd 4241 15 1 1 CD cord-010119-t1x9gknd 4241 16 , , , cord-010119-t1x9gknd 4241 17 4 4 CD cord-010119-t1x9gknd 4241 18 or or CC cord-010119-t1x9gknd 4241 19 5 5 CD cord-010119-t1x9gknd 4241 20 and and CC cord-010119-t1x9gknd 4241 21 8 8 CD cord-010119-t1x9gknd 4241 22 . . . cord-010119-t1x9gknd 4242 1 The the DT cord-010119-t1x9gknd 4242 2 diabetic diabetic JJ cord-010119-t1x9gknd 4242 3 marker marker NN cord-010119-t1x9gknd 4242 4 HbA1c HbA1c NNP cord-010119-t1x9gknd 4242 5 was be VBD cord-010119-t1x9gknd 4242 6 determined determine VBN cord-010119-t1x9gknd 4242 7 in in IN cord-010119-t1x9gknd 4242 8 red red JJ cord-010119-t1x9gknd 4242 9 cells cell NNS cord-010119-t1x9gknd 4242 10 and and CC cord-010119-t1x9gknd 4242 11 cholesterol cholesterol NN cord-010119-t1x9gknd 4242 12 and and CC cord-010119-t1x9gknd 4242 13 triglyceride triglyceride NN cord-010119-t1x9gknd 4242 14 levels level NNS cord-010119-t1x9gknd 4242 15 in in IN cord-010119-t1x9gknd 4242 16 plasma plasma NN cord-010119-t1x9gknd 4242 17 . . . cord-010119-t1x9gknd 4243 1 From from IN cord-010119-t1x9gknd 4243 2 both both DT cord-010119-t1x9gknd 4243 3 groups group NNS cord-010119-t1x9gknd 4243 4 3 3 CD cord-010119-t1x9gknd 4243 5 ' ' `` cord-010119-t1x9gknd 4243 6 good good JJ cord-010119-t1x9gknd 4243 7 ' ' '' cord-010119-t1x9gknd 4243 8 ( ( -LRB- cord-010119-t1x9gknd 4243 9 pH pH NNP cord-010119-t1x9gknd 4243 10 day8 day8 NNP cord-010119-t1x9gknd 4243 11 > > NNP cord-010119-t1x9gknd 4243 12 6.6 6.6 CD cord-010119-t1x9gknd 4243 13 ) ) -RRB- cord-010119-t1x9gknd 4243 14 and and CC cord-010119-t1x9gknd 4243 15 3 3 CD cord-010119-t1x9gknd 4243 16 ' ' `` cord-010119-t1x9gknd 4243 17 poor poor JJ cord-010119-t1x9gknd 4243 18 ' ' '' cord-010119-t1x9gknd 4244 1 ( ( -LRB- cord-010119-t1x9gknd 4244 2 pH pH NNP cord-010119-t1x9gknd 4244 3 day8 day8 VBD cord-010119-t1x9gknd 4244 4 < < NNP cord-010119-t1x9gknd 4244 5 6.3 6.3 CD cord-010119-t1x9gknd 4244 6 ) ) -RRB- cord-010119-t1x9gknd 4244 7 storing store VBG cord-010119-t1x9gknd 4244 8 sPC sPC NNS cord-010119-t1x9gknd 4244 9 were be VBD cord-010119-t1x9gknd 4244 10 selected select VBN cord-010119-t1x9gknd 4244 11 and and CC cord-010119-t1x9gknd 4244 12 analysed analyse VBN cord-010119-t1x9gknd 4244 13 in in IN cord-010119-t1x9gknd 4244 14 more more JJR cord-010119-t1x9gknd 4244 15 detail detail NN cord-010119-t1x9gknd 4244 16 . . . cord-010119-t1x9gknd 4245 1 Results/ Results/ . cord-010119-t1x9gknd 4246 1 Finding finding NN cord-010119-t1x9gknd 4246 2 : : : cord-010119-t1x9gknd 4247 1 Donors donor NNS cord-010119-t1x9gknd 4247 2 were be VBD cord-010119-t1x9gknd 4247 3 of of IN cord-010119-t1x9gknd 4247 4 age age NN cord-010119-t1x9gknd 4247 5 57 57 CD cord-010119-t1x9gknd 4247 6 6 6 CD cord-010119-t1x9gknd 4247 7 10 10 CD cord-010119-t1x9gknd 4247 8 year year NN cord-010119-t1x9gknd 4247 9 and and CC cord-010119-t1x9gknd 4247 10 primarily primarily RB cord-010119-t1x9gknd 4247 11 men man NNS cord-010119-t1x9gknd 4247 12 ( ( -LRB- cord-010119-t1x9gknd 4247 13 75 75 CD cord-010119-t1x9gknd 4247 14 % % NN cord-010119-t1x9gknd 4247 15 ) ) -RRB- cord-010119-t1x9gknd 4247 16 . . . cord-010119-t1x9gknd 4248 1 Donors donor NNS cord-010119-t1x9gknd 4248 2 with with IN cord-010119-t1x9gknd 4248 3 T2D t2d DT cord-010119-t1x9gknd 4248 4 had have VBD cord-010119-t1x9gknd 4248 5 a a DT cord-010119-t1x9gknd 4248 6 higher high JJR cord-010119-t1x9gknd 4248 7 mean mean JJ cord-010119-t1x9gknd 4248 8 BMI BMI NNP cord-010119-t1x9gknd 4248 9 ( ( -LRB- cord-010119-t1x9gknd 4248 10 30.3 30.3 CD cord-010119-t1x9gknd 4248 11 6 6 CD cord-010119-t1x9gknd 4248 12 4.6 4.6 CD cord-010119-t1x9gknd 4248 13 vs.25.4 vs.25.4 NNS cord-010119-t1x9gknd 4248 14 6 6 CD cord-010119-t1x9gknd 4248 15 3.4 3.4 CD cord-010119-t1x9gknd 4248 16 kg kg NN cord-010119-t1x9gknd 4248 17 / / SYM cord-010119-t1x9gknd 4248 18 m m NN cord-010119-t1x9gknd 4248 19 2 2 CD cord-010119-t1x9gknd 4248 20 ) ) -RRB- cord-010119-t1x9gknd 4248 21 and and CC cord-010119-t1x9gknd 4248 22 higher high JJR cord-010119-t1x9gknd 4248 23 HbA1c hba1c NN cord-010119-t1x9gknd 4248 24 than than IN cord-010119-t1x9gknd 4248 25 controls control NNS cord-010119-t1x9gknd 4248 26 . . . cord-010119-t1x9gknd 4249 1 The the DT cord-010119-t1x9gknd 4249 2 sPC sPC NNS cord-010119-t1x9gknd 4249 3 of of IN cord-010119-t1x9gknd 4249 4 both both DT cord-010119-t1x9gknd 4249 5 groups group NNS cord-010119-t1x9gknd 4249 6 had have VBD cord-010119-t1x9gknd 4249 7 the the DT cord-010119-t1x9gknd 4249 8 same same JJ cord-010119-t1x9gknd 4249 9 volume volume NN cord-010119-t1x9gknd 4249 10 ( ( -LRB- cord-010119-t1x9gknd 4249 11 70 70 CD cord-010119-t1x9gknd 4249 12 6 6 CD cord-010119-t1x9gknd 4249 13 5 5 CD cord-010119-t1x9gknd 4249 14 vs vs IN cord-010119-t1x9gknd 4249 15 726 726 CD cord-010119-t1x9gknd 4249 16 2 2 CD cord-010119-t1x9gknd 4249 17 mL ml NN cord-010119-t1x9gknd 4249 18 ) ) -RRB- cord-010119-t1x9gknd 4249 19 and and CC cord-010119-t1x9gknd 4249 20 PLT PLT NNP cord-010119-t1x9gknd 4249 21 content content NN cord-010119-t1x9gknd 4249 22 ( ( -LRB- cord-010119-t1x9gknd 4249 23 71 71 CD cord-010119-t1x9gknd 4249 24 6 6 CD cord-010119-t1x9gknd 4249 25 9 9 CD cord-010119-t1x9gknd 4249 26 vs vs IN cord-010119-t1x9gknd 4249 27 73 73 CD cord-010119-t1x9gknd 4249 28 6 6 CD cord-010119-t1x9gknd 4249 29 11x10 11x10 CD cord-010119-t1x9gknd 4249 30 9 9 CD cord-010119-t1x9gknd 4249 31 ) ) -RRB- cord-010119-t1x9gknd 4249 32 but but CC cord-010119-t1x9gknd 4249 33 on on IN cord-010119-t1x9gknd 4249 34 Day day NN cord-010119-t1x9gknd 4249 35 1 1 CD cord-010119-t1x9gknd 4249 36 glucose glucose NN cord-010119-t1x9gknd 4249 37 concentration concentration NN cord-010119-t1x9gknd 4249 38 was be VBD cord-010119-t1x9gknd 4249 39 higher high JJR cord-010119-t1x9gknd 4249 40 in in IN cord-010119-t1x9gknd 4249 41 the the DT cord-010119-t1x9gknd 4249 42 diabetic diabetic JJ cord-010119-t1x9gknd 4249 43 group group NN cord-010119-t1x9gknd 4249 44 ( ( -LRB- cord-010119-t1x9gknd 4249 45 20.5 20.5 CD cord-010119-t1x9gknd 4249 46 6 6 CD cord-010119-t1x9gknd 4249 47 1.7 1.7 CD cord-010119-t1x9gknd 4249 48 vs vs IN cord-010119-t1x9gknd 4249 49 18.9 18.9 CD cord-010119-t1x9gknd 4249 50 6 6 CD cord-010119-t1x9gknd 4249 51 1.4 1.4 CD cord-010119-t1x9gknd 4249 52 mM mm CD cord-010119-t1x9gknd 4249 53 , , , cord-010119-t1x9gknd 4249 54 p<0.05 p<0.05 CD cord-010119-t1x9gknd 4249 55 ) ) -RRB- cord-010119-t1x9gknd 4249 56 . . . cord-010119-t1x9gknd 4250 1 On on IN cord-010119-t1x9gknd 4250 2 Day Day NNP cord-010119-t1x9gknd 4250 3 8 8 CD cord-010119-t1x9gknd 4250 4 , , , cord-010119-t1x9gknd 4250 5 the the DT cord-010119-t1x9gknd 4250 6 average average NN cord-010119-t1x9gknd 4250 7 in in IN cord-010119-t1x9gknd 4250 8 vitro vitro FW cord-010119-t1x9gknd 4250 9 quality quality NN cord-010119-t1x9gknd 4250 10 was be VBD cord-010119-t1x9gknd 4250 11 comparable comparable JJ cord-010119-t1x9gknd 4250 12 in in IN cord-010119-t1x9gknd 4250 13 both both DT cord-010119-t1x9gknd 4250 14 groups group NNS cord-010119-t1x9gknd 4250 15 ( ( -LRB- cord-010119-t1x9gknd 4250 16 data datum NNS cord-010119-t1x9gknd 4250 17 not not RB cord-010119-t1x9gknd 4250 18 shown show VBN cord-010119-t1x9gknd 4250 19 ) ) -RRB- cord-010119-t1x9gknd 4250 20 . . . cord-010119-t1x9gknd 4251 1 When when WRB cord-010119-t1x9gknd 4251 2 combining combine VBG cord-010119-t1x9gknd 4251 3 94A 94a CD cord-010119-t1x9gknd 4251 4 TRANSFUSION transfusion NN cord-010119-t1x9gknd 4251 5 2017 2017 CD cord-010119-t1x9gknd 4251 6 Vol Vol NNP cord-010119-t1x9gknd 4251 7 . . . cord-010119-t1x9gknd 4252 1 57 57 CD cord-010119-t1x9gknd 4252 2 Supplement supplement NN cord-010119-t1x9gknd 4252 3 S3 S3 NNP cord-010119-t1x9gknd 4252 4 the the DT cord-010119-t1x9gknd 4252 5 selected select VBN cord-010119-t1x9gknd 4252 6 ' ' `` cord-010119-t1x9gknd 4252 7 good good JJ cord-010119-t1x9gknd 4252 8 ' ' '' cord-010119-t1x9gknd 4252 9 and and CC cord-010119-t1x9gknd 4252 10 ' ' `` cord-010119-t1x9gknd 4252 11 poor poor JJ cord-010119-t1x9gknd 4252 12 ' ' '' cord-010119-t1x9gknd 4252 13 storing store VBG cord-010119-t1x9gknd 4252 14 PLT PLT NNP cord-010119-t1x9gknd 4252 15 from from IN cord-010119-t1x9gknd 4252 16 both both DT cord-010119-t1x9gknd 4252 17 groups group NNS cord-010119-t1x9gknd 4252 18 , , , cord-010119-t1x9gknd 4252 19 a a DT cord-010119-t1x9gknd 4252 20 large large JJ cord-010119-t1x9gknd 4252 21 difference difference NN cord-010119-t1x9gknd 4252 22 in in IN cord-010119-t1x9gknd 4252 23 lactate lactate NN cord-010119-t1x9gknd 4252 24 production production NN cord-010119-t1x9gknd 4252 25 was be VBD cord-010119-t1x9gknd 4252 26 observed observe VBN cord-010119-t1x9gknd 4252 27 ( ( -LRB- cord-010119-t1x9gknd 4252 28 0.14 0.14 CD cord-010119-t1x9gknd 4252 29 6 6 CD cord-010119-t1x9gknd 4252 30 0.04 0.04 CD cord-010119-t1x9gknd 4252 31 vs vs IN cord-010119-t1x9gknd 4252 32 0.36 0.36 CD cord-010119-t1x9gknd 4252 33 6 6 CD cord-010119-t1x9gknd 4252 34 0.03 0.03 CD cord-010119-t1x9gknd 4252 35 mmol/ mmol/ CD cord-010119-t1x9gknd 4252 36 day/10 day/10 VBD cord-010119-t1x9gknd 4252 37 11 11 CD cord-010119-t1x9gknd 4252 38 PLT PLT NNP cord-010119-t1x9gknd 4252 39 ) ) -RRB- cord-010119-t1x9gknd 4252 40 . . . cord-010119-t1x9gknd 4253 1 The the DT cord-010119-t1x9gknd 4253 2 ' ' `` cord-010119-t1x9gknd 4253 3 poor poor JJ cord-010119-t1x9gknd 4253 4 ' ' '' cord-010119-t1x9gknd 4253 5 PLT PLT NNP cord-010119-t1x9gknd 4253 6 showed show VBD cord-010119-t1x9gknd 4253 7 a a DT cord-010119-t1x9gknd 4253 8 faster fast JJR cord-010119-t1x9gknd 4253 9 decline decline NN cord-010119-t1x9gknd 4253 10 of of IN cord-010119-t1x9gknd 4253 11 the the DT cord-010119-t1x9gknd 4253 12 mitochondrial mitochondrial JJ cord-010119-t1x9gknd 4253 13 membrane membrane NN cord-010119-t1x9gknd 4253 14 potential potential NN cord-010119-t1x9gknd 4253 15 ( ( -LRB- cord-010119-t1x9gknd 4253 16 as as IN cord-010119-t1x9gknd 4253 17 measured measure VBN cord-010119-t1x9gknd 4253 18 with with IN cord-010119-t1x9gknd 4253 19 JC-1 JC-1 NNP cord-010119-t1x9gknd 4253 20 ) ) -RRB- cord-010119-t1x9gknd 4253 21 during during IN cord-010119-t1x9gknd 4253 22 storage storage NN cord-010119-t1x9gknd 4253 23 than than IN cord-010119-t1x9gknd 4253 24 ' ' `` cord-010119-t1x9gknd 4253 25 good good JJ cord-010119-t1x9gknd 4253 26 ' ' '' cord-010119-t1x9gknd 4253 27 PLT PLT NNP cord-010119-t1x9gknd 4253 28 . . . cord-010119-t1x9gknd 4254 1 Remarkably remarkably RB cord-010119-t1x9gknd 4254 2 , , , cord-010119-t1x9gknd 4254 3 a a DT cord-010119-t1x9gknd 4254 4 difference difference NN cord-010119-t1x9gknd 4254 5 in in IN cord-010119-t1x9gknd 4254 6 triglyceride triglyceride NN cord-010119-t1x9gknd 4254 7 levels level NNS cord-010119-t1x9gknd 4254 8 was be VBD cord-010119-t1x9gknd 4254 9 detected detect VBN cord-010119-t1x9gknd 4254 10 on on IN cord-010119-t1x9gknd 4254 11 Day day NN cord-010119-t1x9gknd 4254 12 1 1 CD cord-010119-t1x9gknd 4254 13 ( ( -LRB- cord-010119-t1x9gknd 4254 14 ' ' '' cord-010119-t1x9gknd 4254 15 poor':2.2 poor':2.2 $ cord-010119-t1x9gknd 4254 16 6 6 CD cord-010119-t1x9gknd 4254 17 0.7 0.7 CD cord-010119-t1x9gknd 4254 18 vs vs IN cord-010119-t1x9gknd 4254 19 ' ' '' cord-010119-t1x9gknd 4254 20 good':1.1 good':1.1 $ cord-010119-t1x9gknd 4254 21 6 6 CD cord-010119-t1x9gknd 4254 22 0.2 0.2 CD cord-010119-t1x9gknd 4254 23 , , , cord-010119-t1x9gknd 4254 24 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 4254 25 ) ) -RRB- cord-010119-t1x9gknd 4254 26 . . . cord-010119-t1x9gknd 4255 1 Conclusion conclusion NN cord-010119-t1x9gknd 4255 2 : : : cord-010119-t1x9gknd 4255 3 BC BC NNP cord-010119-t1x9gknd 4255 4 from from IN cord-010119-t1x9gknd 4255 5 donors donor NNS cord-010119-t1x9gknd 4255 6 with with IN cord-010119-t1x9gknd 4255 7 T2D t2d DT cord-010119-t1x9gknd 4255 8 who who WP cord-010119-t1x9gknd 4255 9 did do VBD cord-010119-t1x9gknd 4255 10 not not RB cord-010119-t1x9gknd 4255 11 use use VB cord-010119-t1x9gknd 4255 12 insulin insulin NN cord-010119-t1x9gknd 4255 13 and and CC cord-010119-t1x9gknd 4255 14 fulfilled fulfil VBD cord-010119-t1x9gknd 4255 15 all all DT cord-010119-t1x9gknd 4255 16 donor donor NN cord-010119-t1x9gknd 4255 17 criteria criterion NNS cord-010119-t1x9gknd 4255 18 , , , cord-010119-t1x9gknd 4255 19 were be VBD cord-010119-t1x9gknd 4255 20 comparable comparable JJ cord-010119-t1x9gknd 4255 21 with with IN cord-010119-t1x9gknd 4255 22 BC BC NNP cord-010119-t1x9gknd 4255 23 from from IN cord-010119-t1x9gknd 4255 24 age age NN cord-010119-t1x9gknd 4255 25 and and CC cord-010119-t1x9gknd 4255 26 sex sex NN cord-010119-t1x9gknd 4255 27 matched match VBN cord-010119-t1x9gknd 4255 28 controls control NNS cord-010119-t1x9gknd 4255 29 , , , cord-010119-t1x9gknd 4255 30 and and CC cord-010119-t1x9gknd 4255 31 seem seem VB cord-010119-t1x9gknd 4255 32 suitable suitable JJ cord-010119-t1x9gknd 4255 33 for for IN cord-010119-t1x9gknd 4255 34 preparation preparation NN cord-010119-t1x9gknd 4255 35 of of IN cord-010119-t1x9gknd 4255 36 PC pc NN cord-010119-t1x9gknd 4255 37 . . . cord-010119-t1x9gknd 4256 1 When when WRB cord-010119-t1x9gknd 4256 2 selecting select VBG cord-010119-t1x9gknd 4256 3 the the DT cord-010119-t1x9gknd 4256 4 ' ' `` cord-010119-t1x9gknd 4256 5 good good JJ cord-010119-t1x9gknd 4256 6 ' ' '' cord-010119-t1x9gknd 4256 7 and and CC cord-010119-t1x9gknd 4256 8 ' ' `` cord-010119-t1x9gknd 4256 9 poor poor JJ cord-010119-t1x9gknd 4256 10 ' ' '' cord-010119-t1x9gknd 4256 11 storing store VBG cord-010119-t1x9gknd 4256 12 PLT PLT NNP cord-010119-t1x9gknd 4256 13 from from IN cord-010119-t1x9gknd 4256 14 the the DT cord-010119-t1x9gknd 4256 15 combined combined JJ cord-010119-t1x9gknd 4256 16 groups group NNS cord-010119-t1x9gknd 4256 17 , , , cord-010119-t1x9gknd 4256 18 the the DT cord-010119-t1x9gknd 4256 19 results result NNS cord-010119-t1x9gknd 4256 20 of of IN cord-010119-t1x9gknd 4256 21 our -PRON- PRP$ cord-010119-t1x9gknd 4256 22 previous previous JJ cord-010119-t1x9gknd 4256 23 study study NN cord-010119-t1x9gknd 4256 24 were be VBD cord-010119-t1x9gknd 4256 25 confirmed confirm VBN cord-010119-t1x9gknd 4256 26 , , , cord-010119-t1x9gknd 4256 27 with with IN cord-010119-t1x9gknd 4256 28 significant significant JJ cord-010119-t1x9gknd 4256 29 differences difference NNS cord-010119-t1x9gknd 4256 30 in in IN cord-010119-t1x9gknd 4256 31 glycolysis glycolysis NN cord-010119-t1x9gknd 4256 32 rate rate NN cord-010119-t1x9gknd 4256 33 and and CC cord-010119-t1x9gknd 4256 34 functionality functionality NN cord-010119-t1x9gknd 4256 35 of of IN cord-010119-t1x9gknd 4256 36 mitochondria mitochondrion NNS cord-010119-t1x9gknd 4256 37 . . . cord-010119-t1x9gknd 4257 1 Metabolic Metabolic NNP cord-010119-t1x9gknd 4257 2 Syndrome Syndrome NNP cord-010119-t1x9gknd 4257 3 and and CC cord-010119-t1x9gknd 4257 4 T2D t2d CD cord-010119-t1x9gknd 4257 5 are be VBP cord-010119-t1x9gknd 4257 6 still still RB cord-010119-t1x9gknd 4257 7 suspected suspect VBN cord-010119-t1x9gknd 4257 8 as as IN cord-010119-t1x9gknd 4257 9 health health NN cord-010119-t1x9gknd 4257 10 issues issue NNS cord-010119-t1x9gknd 4257 11 involved involve VBN cord-010119-t1x9gknd 4257 12 in in IN cord-010119-t1x9gknd 4257 13 ' ' `` cord-010119-t1x9gknd 4257 14 poor poor JJ cord-010119-t1x9gknd 4257 15 ' ' '' cord-010119-t1x9gknd 4257 16 storage storage NN cord-010119-t1x9gknd 4257 17 of of IN cord-010119-t1x9gknd 4257 18 PLT PLT NNP cord-010119-t1x9gknd 4257 19 because because IN cord-010119-t1x9gknd 4257 20 donors donor NNS cord-010119-t1x9gknd 4257 21 were be VBD cord-010119-t1x9gknd 4257 22 of of IN cord-010119-t1x9gknd 4257 23 high high JJ cord-010119-t1x9gknd 4257 24 mean mean NN cord-010119-t1x9gknd 4257 25 age age NN cord-010119-t1x9gknd 4257 26 and and CC cord-010119-t1x9gknd 4257 27 because because IN cord-010119-t1x9gknd 4257 28 of of IN cord-010119-t1x9gknd 4257 29 the the DT cord-010119-t1x9gknd 4257 30 observed observed JJ cord-010119-t1x9gknd 4257 31 differences difference NNS cord-010119-t1x9gknd 4257 32 in in IN cord-010119-t1x9gknd 4257 33 triglyceride triglyceride NN cord-010119-t1x9gknd 4257 34 levels level NNS cord-010119-t1x9gknd 4257 35 between between IN cord-010119-t1x9gknd 4257 36 ' ' `` cord-010119-t1x9gknd 4257 37 good good JJ cord-010119-t1x9gknd 4257 38 ' ' '' cord-010119-t1x9gknd 4257 39 and and CC cord-010119-t1x9gknd 4257 40 ' ' `` cord-010119-t1x9gknd 4257 41 poor poor JJ cord-010119-t1x9gknd 4257 42 ' ' '' cord-010119-t1x9gknd 4257 43 stored store VBD cord-010119-t1x9gknd 4257 44 PCs pc NNS cord-010119-t1x9gknd 4257 45 . . . cord-010119-t1x9gknd 4258 1 Whole whole JJ cord-010119-t1x9gknd 4258 2 Blood blood NN cord-010119-t1x9gknd 4258 3 Leukoreduction leukoreduction NN cord-010119-t1x9gknd 4258 4 Failures failure NNS cord-010119-t1x9gknd 4259 1 --Following --followe VBG cord-010119-t1x9gknd 4259 2 Manufacturer Manufacturer NNP cord-010119-t1x9gknd 4259 3 's 's POS cord-010119-t1x9gknd 4259 4 Instructions Instructions NNP cord-010119-t1x9gknd 4259 5 May May MD cord-010119-t1x9gknd 4259 6 Not not RB cord-010119-t1x9gknd 4259 7 be be VB cord-010119-t1x9gknd 4259 8 Enough enough JJ cord-010119-t1x9gknd 4259 9 Karen Karen NNP cord-010119-t1x9gknd 4259 10 Klinker Klinker NNP cord-010119-t1x9gknd 4259 11 * * NFP cord-010119-t1x9gknd 4259 12 , , , cord-010119-t1x9gknd 4259 13 Nancy Nancy NNP cord-010119-t1x9gknd 4259 14 M. M. NNP cord-010119-t1x9gknd 4259 15 Dunbar Dunbar NNP cord-010119-t1x9gknd 4259 16 and and CC cord-010119-t1x9gknd 4259 17 Zbigniew Zbigniew NNP cord-010119-t1x9gknd 4259 18 M. M. NNP cord-010119-t1x9gknd 4259 19 Szczepiorkowski Szczepiorkowski NNP cord-010119-t1x9gknd 4259 20 . . . cord-010119-t1x9gknd 4260 1 Background Background NNP cord-010119-t1x9gknd 4260 2 / / SYM cord-010119-t1x9gknd 4260 3 Case Case NNP cord-010119-t1x9gknd 4260 4 Studies Studies NNPS cord-010119-t1x9gknd 4260 5 : : : cord-010119-t1x9gknd 4261 1 Our -PRON- PRP$ cord-010119-t1x9gknd 4261 2 hospital hospital NN cord-010119-t1x9gknd 4261 3 based base VBN cord-010119-t1x9gknd 4261 4 blood blood NN cord-010119-t1x9gknd 4261 5 donor donor NN cord-010119-t1x9gknd 4261 6 program program NN cord-010119-t1x9gknd 4261 7 uses use VBZ cord-010119-t1x9gknd 4261 8 a a DT cord-010119-t1x9gknd 4261 9 blood blood NN cord-010119-t1x9gknd 4261 10 collection collection NN cord-010119-t1x9gknd 4261 11 system system NN cord-010119-t1x9gknd 4261 12 which which WDT cord-010119-t1x9gknd 4261 13 leukoreduces leukoreduce VBZ cord-010119-t1x9gknd 4261 14 the the DT cord-010119-t1x9gknd 4261 15 unit unit NN cord-010119-t1x9gknd 4261 16 at at IN cord-010119-t1x9gknd 4261 17 room room NN cord-010119-t1x9gknd 4261 18 temperature temperature NN cord-010119-t1x9gknd 4261 19 prior prior RB cord-010119-t1x9gknd 4261 20 to to IN cord-010119-t1x9gknd 4261 21 centrifugation centrifugation NN cord-010119-t1x9gknd 4261 22 . . . cord-010119-t1x9gknd 4262 1 The the DT cord-010119-t1x9gknd 4262 2 manufacturer manufacturer NN cord-010119-t1x9gknd 4262 3 recommends recommend VBZ cord-010119-t1x9gknd 4262 4 minimum minimum NN cord-010119-t1x9gknd 4262 5 wait wait VB cord-010119-t1x9gknd 4262 6 time time NN cord-010119-t1x9gknd 4262 7 of of IN cord-010119-t1x9gknd 4262 8 30 30 CD cord-010119-t1x9gknd 4262 9 minutes minute NNS cord-010119-t1x9gknd 4262 10 prior prior RB cord-010119-t1x9gknd 4262 11 to to IN cord-010119-t1x9gknd 4262 12 filtration filtration NN cord-010119-t1x9gknd 4262 13 . . . cord-010119-t1x9gknd 4263 1 Anecdotally anecdotally RB cord-010119-t1x9gknd 4263 2 , , , cord-010119-t1x9gknd 4263 3 the the DT cord-010119-t1x9gknd 4263 4 vendor vendor NN cord-010119-t1x9gknd 4263 5 states state NNS cord-010119-t1x9gknd 4263 6 waiting wait VBG cord-010119-t1x9gknd 4263 7 an an DT cord-010119-t1x9gknd 4263 8 hour hour NN cord-010119-t1x9gknd 4263 9 improves improve VBZ cord-010119-t1x9gknd 4263 10 the the DT cord-010119-t1x9gknd 4263 11 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4263 12 . . . cord-010119-t1x9gknd 4264 1 We -PRON- PRP cord-010119-t1x9gknd 4264 2 experienced experience VBD cord-010119-t1x9gknd 4264 3 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4264 4 failures failure NNS cord-010119-t1x9gknd 4264 5 in in IN cord-010119-t1x9gknd 4264 6 January January NNP cord-010119-t1x9gknd 4264 7 and and CC cord-010119-t1x9gknd 4264 8 February February NNP cord-010119-t1x9gknd 4264 9 of of IN cord-010119-t1x9gknd 4264 10 2017 2017 CD cord-010119-t1x9gknd 4264 11 detected detect VBN cord-010119-t1x9gknd 4264 12 by by IN cord-010119-t1x9gknd 4264 13 our -PRON- PRP$ cord-010119-t1x9gknd 4264 14 routine routine JJ cord-010119-t1x9gknd 4264 15 QC qc NN cord-010119-t1x9gknd 4264 16 . . . cord-010119-t1x9gknd 4265 1 We -PRON- PRP cord-010119-t1x9gknd 4265 2 initiated initiate VBD cord-010119-t1x9gknd 4265 3 an an DT cord-010119-t1x9gknd 4265 4 investigation investigation NN cord-010119-t1x9gknd 4265 5 as as IN cord-010119-t1x9gknd 4265 6 to to IN cord-010119-t1x9gknd 4265 7 the the DT cord-010119-t1x9gknd 4265 8 cause cause NN cord-010119-t1x9gknd 4265 9 of of IN cord-010119-t1x9gknd 4265 10 these these DT cord-010119-t1x9gknd 4265 11 unexpected unexpected JJ cord-010119-t1x9gknd 4265 12 failures failure NNS cord-010119-t1x9gknd 4265 13 . . . cord-010119-t1x9gknd 4266 1 Study Study NNP cord-010119-t1x9gknd 4266 2 Design Design NNP cord-010119-t1x9gknd 4266 3 / / SYM cord-010119-t1x9gknd 4266 4 Method method NN cord-010119-t1x9gknd 4266 5 : : : cord-010119-t1x9gknd 4266 6 For for IN cord-010119-t1x9gknd 4266 7 each each DT cord-010119-t1x9gknd 4266 8 of of IN cord-010119-t1x9gknd 4266 9 the the DT cord-010119-t1x9gknd 4266 10 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4266 11 failures failure NNS cord-010119-t1x9gknd 4266 12 , , , cord-010119-t1x9gknd 4266 13 the the DT cord-010119-t1x9gknd 4266 14 following following JJ cord-010119-t1x9gknd 4266 15 factors factor NNS cord-010119-t1x9gknd 4266 16 were be VBD cord-010119-t1x9gknd 4266 17 analyzed analyze VBN cord-010119-t1x9gknd 4266 18 : : : cord-010119-t1x9gknd 4266 19 collection collection NN cord-010119-t1x9gknd 4266 20 time time NN cord-010119-t1x9gknd 4266 21 , , , cord-010119-t1x9gknd 4266 22 length length NN cord-010119-t1x9gknd 4266 23 of of IN cord-010119-t1x9gknd 4266 24 filtration filtration NN cord-010119-t1x9gknd 4266 25 , , , cord-010119-t1x9gknd 4266 26 length length NN cord-010119-t1x9gknd 4266 27 of of IN cord-010119-t1x9gknd 4266 28 wait wait NN cord-010119-t1x9gknd 4266 29 time time NN cord-010119-t1x9gknd 4266 30 prior prior RB cord-010119-t1x9gknd 4266 31 to to IN cord-010119-t1x9gknd 4266 32 filtration filtration NN cord-010119-t1x9gknd 4266 33 , , , cord-010119-t1x9gknd 4266 34 platelet platelet NN cord-010119-t1x9gknd 4266 35 count count NN cord-010119-t1x9gknd 4266 36 , , , cord-010119-t1x9gknd 4266 37 staff staff NN cord-010119-t1x9gknd 4266 38 performing perform VBG cord-010119-t1x9gknd 4266 39 the the DT cord-010119-t1x9gknd 4266 40 process process NN cord-010119-t1x9gknd 4266 41 , , , cord-010119-t1x9gknd 4266 42 the the DT cord-010119-t1x9gknd 4266 43 lot lot NN cord-010119-t1x9gknd 4266 44 number number NN cord-010119-t1x9gknd 4266 45 of of IN cord-010119-t1x9gknd 4266 46 the the DT cord-010119-t1x9gknd 4266 47 collection collection NN cord-010119-t1x9gknd 4266 48 system system NN cord-010119-t1x9gknd 4266 49 bag bag NN cord-010119-t1x9gknd 4266 50 , , , cord-010119-t1x9gknd 4266 51 and and CC cord-010119-t1x9gknd 4266 52 whether whether IN cord-010119-t1x9gknd 4266 53 or or CC cord-010119-t1x9gknd 4266 54 not not RB cord-010119-t1x9gknd 4266 55 units unit NNS cord-010119-t1x9gknd 4266 56 collected collect VBN cord-010119-t1x9gknd 4266 57 from from IN cord-010119-t1x9gknd 4266 58 the the DT cord-010119-t1x9gknd 4266 59 same same JJ cord-010119-t1x9gknd 4266 60 donor donor NN cord-010119-t1x9gknd 4266 61 failed fail VBD cord-010119-t1x9gknd 4266 62 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4266 63 in in IN cord-010119-t1x9gknd 4266 64 the the DT cord-010119-t1x9gknd 4266 65 past past NN cord-010119-t1x9gknd 4266 66 . . . cord-010119-t1x9gknd 4267 1 Hemoglobin Hemoglobin NNP cord-010119-t1x9gknd 4267 2 S S NNP cord-010119-t1x9gknd 4267 3 determinations determination NNS cord-010119-t1x9gknd 4267 4 were be VBD cord-010119-t1x9gknd 4267 5 not not RB cord-010119-t1x9gknd 4267 6 sought seek VBN cord-010119-t1x9gknd 4267 7 out out RP cord-010119-t1x9gknd 4267 8 as as IN cord-010119-t1x9gknd 4267 9 no no DT cord-010119-t1x9gknd 4267 10 repeat repeat NN cord-010119-t1x9gknd 4267 11 donor donor NN cord-010119-t1x9gknd 4267 12 failures failure NNS cord-010119-t1x9gknd 4267 13 were be VBD cord-010119-t1x9gknd 4267 14 noted note VBN cord-010119-t1x9gknd 4267 15 and and CC cord-010119-t1x9gknd 4267 16 our -PRON- PRP$ cord-010119-t1x9gknd 4267 17 donor donor NN cord-010119-t1x9gknd 4267 18 population population NN cord-010119-t1x9gknd 4267 19 would would MD cord-010119-t1x9gknd 4267 20 suggest suggest VB cord-010119-t1x9gknd 4267 21 a a DT cord-010119-t1x9gknd 4267 22 minimal minimal JJ cord-010119-t1x9gknd 4267 23 number number NN cord-010119-t1x9gknd 4267 24 of of IN cord-010119-t1x9gknd 4267 25 donors donor NNS cord-010119-t1x9gknd 4267 26 would would MD cord-010119-t1x9gknd 4267 27 be be VB cord-010119-t1x9gknd 4267 28 found find VBN cord-010119-t1x9gknd 4267 29 to to TO cord-010119-t1x9gknd 4267 30 be be VB cord-010119-t1x9gknd 4267 31 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4267 32 S S NNP cord-010119-t1x9gknd 4267 33 positive positive JJ cord-010119-t1x9gknd 4267 34 . . . cord-010119-t1x9gknd 4268 1 Results/ Results/ . cord-010119-t1x9gknd 4269 1 Finding finding NN cord-010119-t1x9gknd 4269 2 : : : cord-010119-t1x9gknd 4270 1 A a DT cord-010119-t1x9gknd 4270 2 relationship relationship NN cord-010119-t1x9gknd 4270 3 was be VBD cord-010119-t1x9gknd 4270 4 established establish VBN cord-010119-t1x9gknd 4270 5 between between IN cord-010119-t1x9gknd 4270 6 the the DT cord-010119-t1x9gknd 4270 7 length length NN cord-010119-t1x9gknd 4270 8 of of IN cord-010119-t1x9gknd 4270 9 time time NN cord-010119-t1x9gknd 4270 10 the the DT cord-010119-t1x9gknd 4270 11 product product NN cord-010119-t1x9gknd 4270 12 rested rest VBD cord-010119-t1x9gknd 4270 13 or or CC cord-010119-t1x9gknd 4270 14 waited wait VBN cord-010119-t1x9gknd 4270 15 prior prior RB cord-010119-t1x9gknd 4270 16 to to IN cord-010119-t1x9gknd 4270 17 filtration filtration NN cord-010119-t1x9gknd 4270 18 and and CC cord-010119-t1x9gknd 4270 19 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4270 20 failure failure NN cord-010119-t1x9gknd 4270 21 . . . cord-010119-t1x9gknd 4271 1 We -PRON- PRP cord-010119-t1x9gknd 4271 2 found find VBD cord-010119-t1x9gknd 4271 3 that that IN cord-010119-t1x9gknd 4271 4 shorter short JJR cord-010119-t1x9gknd 4271 5 wait wait VB cord-010119-t1x9gknd 4271 6 times time NNS cord-010119-t1x9gknd 4271 7 increased increase VBD cord-010119-t1x9gknd 4271 8 the the DT cord-010119-t1x9gknd 4271 9 percentage percentage NN cord-010119-t1x9gknd 4271 10 of of IN cord-010119-t1x9gknd 4271 11 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4271 12 failures failure NNS cord-010119-t1x9gknd 4271 13 ( ( -LRB- cord-010119-t1x9gknd 4271 14 see see VB cord-010119-t1x9gknd 4271 15 table table NN cord-010119-t1x9gknd 4271 16 1 1 CD cord-010119-t1x9gknd 4271 17 ) ) -RRB- cord-010119-t1x9gknd 4271 18 . . . cord-010119-t1x9gknd 4272 1 All all DT cord-010119-t1x9gknd 4272 2 units unit NNS cord-010119-t1x9gknd 4272 3 that that WDT cord-010119-t1x9gknd 4272 4 failed fail VBD cord-010119-t1x9gknd 4272 5 had have VBD cord-010119-t1x9gknd 4272 6 wait wait VB cord-010119-t1x9gknd 4272 7 times time NNS cord-010119-t1x9gknd 4272 8 less less JJR cord-010119-t1x9gknd 4272 9 than than IN cord-010119-t1x9gknd 4272 10 one one CD cord-010119-t1x9gknd 4272 11 hour hour NN cord-010119-t1x9gknd 4272 12 . . . cord-010119-t1x9gknd 4273 1 A a DT cord-010119-t1x9gknd 4273 2 similar similar JJ cord-010119-t1x9gknd 4273 3 trend trend NN cord-010119-t1x9gknd 4273 4 was be VBD cord-010119-t1x9gknd 4273 5 noticed notice VBN cord-010119-t1x9gknd 4273 6 for for IN cord-010119-t1x9gknd 4273 7 the the DT cord-010119-t1x9gknd 4273 8 previous previous JJ cord-010119-t1x9gknd 4273 9 year year NN cord-010119-t1x9gknd 4273 10 . . . cord-010119-t1x9gknd 4274 1 The the DT cord-010119-t1x9gknd 4274 2 investigation investigation NN cord-010119-t1x9gknd 4274 3 showed show VBD cord-010119-t1x9gknd 4274 4 no no DT cord-010119-t1x9gknd 4274 5 relationship relationship NN cord-010119-t1x9gknd 4274 6 between between IN cord-010119-t1x9gknd 4274 7 length length NN cord-010119-t1x9gknd 4274 8 of of IN cord-010119-t1x9gknd 4274 9 collection collection NN cord-010119-t1x9gknd 4274 10 time time NN cord-010119-t1x9gknd 4274 11 , , , cord-010119-t1x9gknd 4274 12 or or CC cord-010119-t1x9gknd 4274 13 the the DT cord-010119-t1x9gknd 4274 14 length length NN cord-010119-t1x9gknd 4274 15 of of IN cord-010119-t1x9gknd 4274 16 filtration filtration NN cord-010119-t1x9gknd 4274 17 time time NN cord-010119-t1x9gknd 4274 18 and and CC cord-010119-t1x9gknd 4274 19 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4274 20 failure failure NN cord-010119-t1x9gknd 4274 21 . . . cord-010119-t1x9gknd 4275 1 Staff staff NN cord-010119-t1x9gknd 4275 2 performing perform VBG cord-010119-t1x9gknd 4275 3 the the DT cord-010119-t1x9gknd 4275 4 filtration filtration NN cord-010119-t1x9gknd 4275 5 was be VBD cord-010119-t1x9gknd 4275 6 ruled rule VBN cord-010119-t1x9gknd 4275 7 out out RP cord-010119-t1x9gknd 4275 8 as as IN cord-010119-t1x9gknd 4275 9 possible possible JJ cord-010119-t1x9gknd 4275 10 cause cause NN cord-010119-t1x9gknd 4275 11 as as IN cord-010119-t1x9gknd 4275 12 the the DT cord-010119-t1x9gknd 4275 13 failures failure NNS cord-010119-t1x9gknd 4275 14 were be VBD cord-010119-t1x9gknd 4275 15 spread spread VBN cord-010119-t1x9gknd 4275 16 out out RP cord-010119-t1x9gknd 4275 17 among among IN cord-010119-t1x9gknd 4275 18 numerous numerous JJ cord-010119-t1x9gknd 4275 19 personnel personnel NNS cord-010119-t1x9gknd 4275 20 and and CC cord-010119-t1x9gknd 4275 21 observation observation NN cord-010119-t1x9gknd 4275 22 of of IN cord-010119-t1x9gknd 4275 23 their -PRON- PRP$ cord-010119-t1x9gknd 4275 24 technique technique NN cord-010119-t1x9gknd 4275 25 displayed display VBD cord-010119-t1x9gknd 4275 26 no no DT cord-010119-t1x9gknd 4275 27 sample sample NN cord-010119-t1x9gknd 4275 28 collection collection NN cord-010119-t1x9gknd 4275 29 issues issue NNS cord-010119-t1x9gknd 4275 30 . . . cord-010119-t1x9gknd 4276 1 Platelet platelet NN cord-010119-t1x9gknd 4276 2 counts count VBZ cord-010119-t1x9gknd 4276 3 on on IN cord-010119-t1x9gknd 4276 4 the the DT cord-010119-t1x9gknd 4276 5 donors donor NNS cord-010119-t1x9gknd 4276 6 involved involve VBN cord-010119-t1x9gknd 4276 7 were be VBD cord-010119-t1x9gknd 4276 8 available available JJ cord-010119-t1x9gknd 4276 9 and and CC cord-010119-t1x9gknd 4276 10 none none NN cord-010119-t1x9gknd 4276 11 were be VBD cord-010119-t1x9gknd 4276 12 outside outside RB cord-010119-t1x9gknd 4276 13 of of IN cord-010119-t1x9gknd 4276 14 the the DT cord-010119-t1x9gknd 4276 15 normal normal JJ cord-010119-t1x9gknd 4276 16 range range NN cord-010119-t1x9gknd 4276 17 . . . cord-010119-t1x9gknd 4277 1 Various various JJ cord-010119-t1x9gknd 4277 2 lot lot NN cord-010119-t1x9gknd 4277 3 numbers number NNS cord-010119-t1x9gknd 4277 4 of of IN cord-010119-t1x9gknd 4277 5 the the DT cord-010119-t1x9gknd 4277 6 collection collection NN cord-010119-t1x9gknd 4277 7 sets set NNS cord-010119-t1x9gknd 4277 8 were be VBD cord-010119-t1x9gknd 4277 9 involved involve VBN cord-010119-t1x9gknd 4277 10 , , , cord-010119-t1x9gknd 4277 11 and and CC cord-010119-t1x9gknd 4277 12 no no DT cord-010119-t1x9gknd 4277 13 donors donor NNS cord-010119-t1x9gknd 4277 14 were be VBD cord-010119-t1x9gknd 4277 15 repeat repeat NN cord-010119-t1x9gknd 4277 16 failures failure NNS cord-010119-t1x9gknd 4277 17 . . . cord-010119-t1x9gknd 4278 1 Conclusion conclusion NN cord-010119-t1x9gknd 4278 2 : : : cord-010119-t1x9gknd 4279 1 In in IN cord-010119-t1x9gknd 4279 2 our -PRON- PRP$ cord-010119-t1x9gknd 4279 3 small small JJ cord-010119-t1x9gknd 4279 4 study study NN cord-010119-t1x9gknd 4279 5 , , , cord-010119-t1x9gknd 4279 6 we -PRON- PRP cord-010119-t1x9gknd 4279 7 found find VBD cord-010119-t1x9gknd 4279 8 that that IN cord-010119-t1x9gknd 4279 9 following follow VBG cord-010119-t1x9gknd 4279 10 manufacturer manufacturer NN cord-010119-t1x9gknd 4279 11 's 's POS cord-010119-t1x9gknd 4279 12 recommendations recommendation NNS cord-010119-t1x9gknd 4279 13 for for IN cord-010119-t1x9gknd 4279 14 the the DT cord-010119-t1x9gknd 4279 15 resting resting NN cord-010119-t1x9gknd 4279 16 or or CC cord-010119-t1x9gknd 4279 17 wait wait VB cord-010119-t1x9gknd 4279 18 time time NN cord-010119-t1x9gknd 4279 19 prior prior RB cord-010119-t1x9gknd 4279 20 to to IN cord-010119-t1x9gknd 4279 21 filtration filtration NN cord-010119-t1x9gknd 4279 22 was be VBD cord-010119-t1x9gknd 4279 23 insufficient insufficient JJ cord-010119-t1x9gknd 4279 24 to to TO cord-010119-t1x9gknd 4279 25 avoid avoid VB cord-010119-t1x9gknd 4279 26 excessive excessive JJ cord-010119-t1x9gknd 4279 27 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4279 28 failures failure NNS cord-010119-t1x9gknd 4279 29 . . . cord-010119-t1x9gknd 4280 1 We -PRON- PRP cord-010119-t1x9gknd 4280 2 extended extend VBD cord-010119-t1x9gknd 4280 3 our -PRON- PRP$ cord-010119-t1x9gknd 4280 4 minimum minimum NN cord-010119-t1x9gknd 4280 5 wait wait NN cord-010119-t1x9gknd 4280 6 time time NN cord-010119-t1x9gknd 4280 7 to to IN cord-010119-t1x9gknd 4280 8 60 60 CD cord-010119-t1x9gknd 4280 9 minutes minute NNS cord-010119-t1x9gknd 4280 10 based base VBN cord-010119-t1x9gknd 4280 11 on on IN cord-010119-t1x9gknd 4280 12 our -PRON- PRP$ cord-010119-t1x9gknd 4280 13 data datum NNS cord-010119-t1x9gknd 4280 14 . . . cord-010119-t1x9gknd 4281 1 We -PRON- PRP cord-010119-t1x9gknd 4281 2 have have VBP cord-010119-t1x9gknd 4281 3 not not RB cord-010119-t1x9gknd 4281 4 experienced experience VBN cord-010119-t1x9gknd 4281 5 any any DT cord-010119-t1x9gknd 4281 6 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4281 7 failures failure NNS cord-010119-t1x9gknd 4281 8 after after IN cord-010119-t1x9gknd 4281 9 this this DT cord-010119-t1x9gknd 4281 10 change change NN cord-010119-t1x9gknd 4281 11 . . . cord-010119-t1x9gknd 4282 1 Absolute Absolute NNP cord-010119-t1x9gknd 4282 2 Immature Immature NNP cord-010119-t1x9gknd 4282 3 Platelet platelet NN cord-010119-t1x9gknd 4282 4 Count Count NNP cord-010119-t1x9gknd 4282 5 in in IN cord-010119-t1x9gknd 4282 6 Diagnostic Diagnostic NNP cord-010119-t1x9gknd 4282 7 Algorithm Algorithm NNP cord-010119-t1x9gknd 4282 8 and and CC cord-010119-t1x9gknd 4282 9 Management Management NNP cord-010119-t1x9gknd 4282 10 of of IN cord-010119-t1x9gknd 4282 11 Pediatric Pediatric NNP cord-010119-t1x9gknd 4282 12 Thrombotic Thrombotic NNP cord-010119-t1x9gknd 4282 13 Microangiopathy Microangiopathy NNP cord-010119-t1x9gknd 4283 1 Hamza Hamza NNP cord-010119-t1x9gknd 4283 2 N N NNP cord-010119-t1x9gknd 4283 3 Gokozan Gokozan NNP cord-010119-t1x9gknd 4283 4 * * NFP cord-010119-t1x9gknd 4283 5 1,2 1,2 CD cord-010119-t1x9gknd 4283 6 , , , cord-010119-t1x9gknd 4283 7 Katharine Katharine NNP cord-010119-t1x9gknd 4283 8 A a DT cord-010119-t1x9gknd 4283 9 Downes Downes NNP cord-010119-t1x9gknd 4283 10 1,2 1,2 CD cord-010119-t1x9gknd 4283 11 , , , cord-010119-t1x9gknd 4283 12 Hollie Hollie NNP cord-010119-t1x9gknd 4283 13 M M NNP cord-010119-t1x9gknd 4283 14 Reeves Reeves NNP cord-010119-t1x9gknd 4283 15 1,2 1,2 CD cord-010119-t1x9gknd 4283 16 and and CC cord-010119-t1x9gknd 4283 17 Robert Robert NNP cord-010119-t1x9gknd 4283 18 W W NNP cord-010119-t1x9gknd 4283 19 Maitta Maitta NNP cord-010119-t1x9gknd 4283 20 1,2 1,2 CD cord-010119-t1x9gknd 4283 21 . . . cord-010119-t1x9gknd 4284 1 1 1 LS cord-010119-t1x9gknd 4285 1 Case Case NNP cord-010119-t1x9gknd 4285 2 Western Western NNP cord-010119-t1x9gknd 4285 3 Reserve Reserve NNP cord-010119-t1x9gknd 4285 4 University University NNP cord-010119-t1x9gknd 4285 5 School School NNP cord-010119-t1x9gknd 4285 6 of of IN cord-010119-t1x9gknd 4285 7 Medicine Medicine NNP cord-010119-t1x9gknd 4285 8 , , , cord-010119-t1x9gknd 4285 9 2 2 CD cord-010119-t1x9gknd 4285 10 University University NNP cord-010119-t1x9gknd 4285 11 Hospitals Hospitals NNPS cord-010119-t1x9gknd 4285 12 Cleveland Cleveland NNP cord-010119-t1x9gknd 4285 13 Medical Medical NNP cord-010119-t1x9gknd 4285 14 Center Center NNP cord-010119-t1x9gknd 4285 15 Background Background NNP cord-010119-t1x9gknd 4285 16 / / SYM cord-010119-t1x9gknd 4285 17 Case Case NNP cord-010119-t1x9gknd 4285 18 Studies Studies NNPS cord-010119-t1x9gknd 4286 1 : : : cord-010119-t1x9gknd 4286 2 Prior Prior NNP cord-010119-t1x9gknd 4286 3 studies study NNS cord-010119-t1x9gknd 4286 4 highlighted highlight VBD cord-010119-t1x9gknd 4286 5 the the DT cord-010119-t1x9gknd 4286 6 utility utility NN cord-010119-t1x9gknd 4286 7 of of IN cord-010119-t1x9gknd 4286 8 absolute absolute JJ cord-010119-t1x9gknd 4286 9 immature immature JJ cord-010119-t1x9gknd 4286 10 platelet platelet NN cord-010119-t1x9gknd 4286 11 count count NN cord-010119-t1x9gknd 4286 12 ( ( -LRB- cord-010119-t1x9gknd 4286 13 A A NNP cord-010119-t1x9gknd 4286 14 - - HYPH cord-010119-t1x9gknd 4286 15 IPC IPC NNP cord-010119-t1x9gknd 4286 16 ) ) -RRB- cord-010119-t1x9gknd 4286 17 and and CC cord-010119-t1x9gknd 4286 18 A A NNP cord-010119-t1x9gknd 4286 19 - - HYPH cord-010119-t1x9gknd 4286 20 IPC IPC NNP cord-010119-t1x9gknd 4286 21 ratio ratio NN cord-010119-t1x9gknd 4286 22 once once IN cord-010119-t1x9gknd 4286 23 therapeutic therapeutic JJ cord-010119-t1x9gknd 4286 24 plasma plasma NN cord-010119-t1x9gknd 4286 25 exchange exchange NN cord-010119-t1x9gknd 4286 26 ( ( -LRB- cord-010119-t1x9gknd 4286 27 TPE TPE NNP cord-010119-t1x9gknd 4286 28 ) ) -RRB- cord-010119-t1x9gknd 4286 29 is be VBZ cord-010119-t1x9gknd 4286 30 initiated initiate VBN cord-010119-t1x9gknd 4286 31 to to TO cord-010119-t1x9gknd 4286 32 differentiate differentiate VB cord-010119-t1x9gknd 4286 33 thrombotic thrombotic JJ cord-010119-t1x9gknd 4286 34 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 4286 35 purpura purpura NN cord-010119-t1x9gknd 4286 36 ( ( -LRB- cord-010119-t1x9gknd 4286 37 TTP TTP NNP cord-010119-t1x9gknd 4286 38 ) ) -RRB- cord-010119-t1x9gknd 4286 39 from from IN cord-010119-t1x9gknd 4286 40 other other JJ cord-010119-t1x9gknd 4286 41 thrombotic thrombotic JJ cord-010119-t1x9gknd 4286 42 microangiopathies microangiopathie NNS cord-010119-t1x9gknd 4286 43 . . . cord-010119-t1x9gknd 4287 1 This this DT cord-010119-t1x9gknd 4287 2 can can MD cord-010119-t1x9gknd 4287 3 be be VB cord-010119-t1x9gknd 4287 4 helpful helpful JJ cord-010119-t1x9gknd 4287 5 to to TO cord-010119-t1x9gknd 4287 6 determine determine VB cord-010119-t1x9gknd 4287 7 those those DT cord-010119-t1x9gknd 4287 8 who who WP cord-010119-t1x9gknd 4287 9 may may MD cord-010119-t1x9gknd 4287 10 benefit benefit VB cord-010119-t1x9gknd 4287 11 from from IN cord-010119-t1x9gknd 4287 12 prompt prompt JJ cord-010119-t1x9gknd 4287 13 initiation initiation NN cord-010119-t1x9gknd 4287 14 of of IN cord-010119-t1x9gknd 4287 15 TPE TPE NNP cord-010119-t1x9gknd 4287 16 when when WRB cord-010119-t1x9gknd 4287 17 tests test NNS cord-010119-t1x9gknd 4287 18 such such JJ cord-010119-t1x9gknd 4287 19 as as IN cord-010119-t1x9gknd 4287 20 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4287 21 are be VBP cord-010119-t1x9gknd 4287 22 not not RB cord-010119-t1x9gknd 4287 23 readily readily RB cord-010119-t1x9gknd 4287 24 available available JJ cord-010119-t1x9gknd 4287 25 . . . cord-010119-t1x9gknd 4288 1 We -PRON- PRP cord-010119-t1x9gknd 4288 2 report report VBP cord-010119-t1x9gknd 4288 3 a a DT cord-010119-t1x9gknd 4288 4 young young JJ cord-010119-t1x9gknd 4288 5 pediatric pediatric JJ cord-010119-t1x9gknd 4288 6 patient patient NN cord-010119-t1x9gknd 4288 7 presenting present VBG cord-010119-t1x9gknd 4288 8 with with IN cord-010119-t1x9gknd 4288 9 diarrhea diarrhea NN cord-010119-t1x9gknd 4288 10 in in IN cord-010119-t1x9gknd 4288 11 the the DT cord-010119-t1x9gknd 4288 12 setting setting NN cord-010119-t1x9gknd 4288 13 of of IN cord-010119-t1x9gknd 4288 14 laboratory laboratory NN cord-010119-t1x9gknd 4288 15 results result NNS cord-010119-t1x9gknd 4288 16 suggestive suggestive JJ cord-010119-t1x9gknd 4288 17 of of IN cord-010119-t1x9gknd 4288 18 a a DT cord-010119-t1x9gknd 4288 19 microangiopathic microangiopathic JJ cord-010119-t1x9gknd 4288 20 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 4288 21 suspicious suspicious JJ cord-010119-t1x9gknd 4288 22 for for IN cord-010119-t1x9gknd 4288 23 TTP TTP NNP cord-010119-t1x9gknd 4288 24 in in IN cord-010119-t1x9gknd 4288 25 which which WDT cord-010119-t1x9gknd 4288 26 A A NNP cord-010119-t1x9gknd 4288 27 - - HYPH cord-010119-t1x9gknd 4288 28 IPC IPC NNP cord-010119-t1x9gknd 4288 29 measurement measurement NN cord-010119-t1x9gknd 4288 30 was be VBD cord-010119-t1x9gknd 4288 31 clinically clinically RB cord-010119-t1x9gknd 4288 32 useful useful JJ cord-010119-t1x9gknd 4288 33 . . . cord-010119-t1x9gknd 4289 1 Study Study NNP cord-010119-t1x9gknd 4289 2 Design Design NNP cord-010119-t1x9gknd 4289 3 / / SYM cord-010119-t1x9gknd 4289 4 Methods method NNS cord-010119-t1x9gknd 4289 5 : : : cord-010119-t1x9gknd 4290 1 Previously previously RB cord-010119-t1x9gknd 4290 2 healthy healthy JJ cord-010119-t1x9gknd 4290 3 12 12 CD cord-010119-t1x9gknd 4290 4 month month NN cord-010119-t1x9gknd 4290 5 old old JJ cord-010119-t1x9gknd 4290 6 unvaccinated unvaccinated JJ cord-010119-t1x9gknd 4290 7 girl girl NN cord-010119-t1x9gknd 4290 8 presented present VBN cord-010119-t1x9gknd 4290 9 with with IN cord-010119-t1x9gknd 4290 10 history history NN cord-010119-t1x9gknd 4290 11 of of IN cord-010119-t1x9gknd 4290 12 diarrhea diarrhea NN cord-010119-t1x9gknd 4290 13 for for IN cord-010119-t1x9gknd 4290 14 5 5 CD cord-010119-t1x9gknd 4290 15 days day NNS cord-010119-t1x9gknd 4290 16 which which WDT cord-010119-t1x9gknd 4290 17 was be VBD cord-010119-t1x9gknd 4290 18 bloody bloody JJ cord-010119-t1x9gknd 4290 19 at at IN cord-010119-t1x9gknd 4290 20 onset onset NN cord-010119-t1x9gknd 4290 21 , , , cord-010119-t1x9gknd 4290 22 accompanied accompany VBN cord-010119-t1x9gknd 4290 23 by by IN cord-010119-t1x9gknd 4290 24 fever fever NN cord-010119-t1x9gknd 4290 25 and and CC cord-010119-t1x9gknd 4290 26 dehydration dehydration NN cord-010119-t1x9gknd 4290 27 . . . cord-010119-t1x9gknd 4291 1 Laboratory laboratory NN cord-010119-t1x9gknd 4291 2 results result NNS cord-010119-t1x9gknd 4291 3 showed show VBD cord-010119-t1x9gknd 4291 4 : : : cord-010119-t1x9gknd 4291 5 white white JJ cord-010119-t1x9gknd 4291 6 blood blood NN cord-010119-t1x9gknd 4291 7 cell cell NN cord-010119-t1x9gknd 4291 8 count count NN cord-010119-t1x9gknd 4291 9 : : : cord-010119-t1x9gknd 4292 1 32 32 CD cord-010119-t1x9gknd 4292 2 x x SYM cord-010119-t1x9gknd 4292 3 10 10 CD cord-010119-t1x9gknd 4292 4 9 9 CD cord-010119-t1x9gknd 4292 5 /L /l CD cord-010119-t1x9gknd 4292 6 , , , cord-010119-t1x9gknd 4292 7 platelets platelet NNS cord-010119-t1x9gknd 4292 8 : : : cord-010119-t1x9gknd 4292 9 62 62 CD cord-010119-t1x9gknd 4292 10 x x SYM cord-010119-t1x9gknd 4292 11 10 10 CD cord-010119-t1x9gknd 4292 12 9 9 CD cord-010119-t1x9gknd 4292 13 /L /L , cord-010119-t1x9gknd 4292 14 , , , cord-010119-t1x9gknd 4292 15 BUN bun NN cord-010119-t1x9gknd 4292 16 : : : cord-010119-t1x9gknd 4292 17 77mg 77mg LS cord-010119-t1x9gknd 4292 18 / / SYM cord-010119-t1x9gknd 4292 19 dL dl NN cord-010119-t1x9gknd 4292 20 , , , cord-010119-t1x9gknd 4292 21 creatinine creatinine NN cord-010119-t1x9gknd 4292 22 : : : cord-010119-t1x9gknd 4292 23 2.4mg 2.4mg CD cord-010119-t1x9gknd 4292 24 / / SYM cord-010119-t1x9gknd 4292 25 dL dl NN cord-010119-t1x9gknd 4292 26 , , , cord-010119-t1x9gknd 4292 27 lactate lactate NN cord-010119-t1x9gknd 4292 28 dehydrogenase dehydrogenase NN cord-010119-t1x9gknd 4292 29 1940 1940 CD cord-010119-t1x9gknd 4292 30 U U NNP cord-010119-t1x9gknd 4292 31 / / SYM cord-010119-t1x9gknd 4292 32 L. L. NNP cord-010119-t1x9gknd 4292 33 Hospital Hospital NNP cord-010119-t1x9gknd 4292 34 course course NN cord-010119-t1x9gknd 4292 35 was be VBD cord-010119-t1x9gknd 4292 36 complicated complicate VBN cord-010119-t1x9gknd 4292 37 by by IN cord-010119-t1x9gknd 4292 38 tonicclonic tonicclonic JJ cord-010119-t1x9gknd 4292 39 seizure seizure NN cord-010119-t1x9gknd 4292 40 episodes episode NNS cord-010119-t1x9gknd 4292 41 that that WDT cord-010119-t1x9gknd 4292 42 stopped stop VBD cord-010119-t1x9gknd 4292 43 with with IN cord-010119-t1x9gknd 4292 44 anti anti JJ cord-010119-t1x9gknd 4292 45 - - NNS cord-010119-t1x9gknd 4292 46 convulsants convulsant NNS cord-010119-t1x9gknd 4292 47 and and CC cord-010119-t1x9gknd 4292 48 acute acute JJ cord-010119-t1x9gknd 4292 49 kidney kidney NN cord-010119-t1x9gknd 4292 50 injury injury NN cord-010119-t1x9gknd 4292 51 requiring require VBG cord-010119-t1x9gknd 4292 52 hemodialysis hemodialysis NN cord-010119-t1x9gknd 4292 53 . . . cord-010119-t1x9gknd 4293 1 Peripheral peripheral JJ cord-010119-t1x9gknd 4293 2 blood blood NN cord-010119-t1x9gknd 4293 3 smear smear NN cord-010119-t1x9gknd 4293 4 revealed reveal VBD cord-010119-t1x9gknd 4293 5 schistocytes schistocyte NNS cord-010119-t1x9gknd 4293 6 . . . cord-010119-t1x9gknd 4294 1 On on IN cord-010119-t1x9gknd 4294 2 third third JJ cord-010119-t1x9gknd 4294 3 day day NN cord-010119-t1x9gknd 4294 4 of of IN cord-010119-t1x9gknd 4294 5 hospitalization hospitalization NN cord-010119-t1x9gknd 4294 6 , , , cord-010119-t1x9gknd 4294 7 platelet platelet NN cord-010119-t1x9gknd 4294 8 count count NN cord-010119-t1x9gknd 4294 9 decreased decrease VBD cord-010119-t1x9gknd 4294 10 to to IN cord-010119-t1x9gknd 4294 11 44 44 CD cord-010119-t1x9gknd 4294 12 x x SYM cord-010119-t1x9gknd 4294 13 10 10 CD cord-010119-t1x9gknd 4294 14 9 9 CD cord-010119-t1x9gknd 4294 15 /L /l CD cord-010119-t1x9gknd 4294 16 , , , cord-010119-t1x9gknd 4294 17 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4294 18 sample sample NN cord-010119-t1x9gknd 4294 19 was be VBD cord-010119-t1x9gknd 4294 20 sent send VBN cord-010119-t1x9gknd 4294 21 out out RP cord-010119-t1x9gknd 4294 22 and and CC cord-010119-t1x9gknd 4294 23 TPE TPE NNP cord-010119-t1x9gknd 4294 24 was be VBD cord-010119-t1x9gknd 4294 25 initiated initiate VBN cord-010119-t1x9gknd 4294 26 for for IN cord-010119-t1x9gknd 4294 27 clinical clinical JJ cord-010119-t1x9gknd 4294 28 suspicion suspicion NN cord-010119-t1x9gknd 4294 29 of of IN cord-010119-t1x9gknd 4294 30 TTP TTP NNP cord-010119-t1x9gknd 4294 31 versus versus IN cord-010119-t1x9gknd 4294 32 hemolytic hemolytic JJ cord-010119-t1x9gknd 4294 33 uremic uremic JJ cord-010119-t1x9gknd 4294 34 syndrome syndrome NN cord-010119-t1x9gknd 4294 35 , , , cord-010119-t1x9gknd 4294 36 atypical atypical JJ cord-010119-t1x9gknd 4294 37 versus versus IN cord-010119-t1x9gknd 4294 38 Shiga shiga NN cord-010119-t1x9gknd 4294 39 - - HYPH cord-010119-t1x9gknd 4294 40 toxin toxin NN cord-010119-t1x9gknd 4294 41 mediated mediate VBN cord-010119-t1x9gknd 4294 42 . . . cord-010119-t1x9gknd 4295 1 Immature immature JJ cord-010119-t1x9gknd 4295 2 platelet platelet NN cord-010119-t1x9gknd 4295 3 fraction fraction NN cord-010119-t1x9gknd 4295 4 ( ( -LRB- cord-010119-t1x9gknd 4295 5 % % NN cord-010119-t1x9gknd 4295 6 -IPF -ipf CD cord-010119-t1x9gknd 4295 7 ) ) -RRB- cord-010119-t1x9gknd 4295 8 and and CC cord-010119-t1x9gknd 4295 9 calculated calculate VBD cord-010119-t1x9gknd 4295 10 A A NNP cord-010119-t1x9gknd 4295 11 - - HYPH cord-010119-t1x9gknd 4295 12 IPC IPC NNP cord-010119-t1x9gknd 4295 13 ( ( -LRB- cord-010119-t1x9gknd 4295 14 % % NN cord-010119-t1x9gknd 4295 15 -IPF -ipf SYM cord-010119-t1x9gknd 4295 16 x x SYM cord-010119-t1x9gknd 4295 17 platelet platelet NN cord-010119-t1x9gknd 4295 18 count count NN cord-010119-t1x9gknd 4295 19 ) ) -RRB- cord-010119-t1x9gknd 4295 20 were be VBD cord-010119-t1x9gknd 4295 21 obtained obtain VBN cord-010119-t1x9gknd 4295 22 with with IN cord-010119-t1x9gknd 4295 23 daily daily JJ cord-010119-t1x9gknd 4295 24 pre pre JJ cord-010119-t1x9gknd 4295 25 - - NNP cord-010119-t1x9gknd 4295 26 TPE TPE NNP cord-010119-t1x9gknd 4295 27 CBC CBC NNP cord-010119-t1x9gknd 4295 28 . . . cord-010119-t1x9gknd 4296 1 A a LS cord-010119-t1x9gknd 4296 2 - - HYPH cord-010119-t1x9gknd 4296 3 IPC IPC NNP cord-010119-t1x9gknd 4296 4 ratio ratio NN cord-010119-t1x9gknd 4296 5 was be VBD cord-010119-t1x9gknd 4296 6 calculated calculate VBN cord-010119-t1x9gknd 4296 7 from from IN cord-010119-t1x9gknd 4296 8 baseline baseline NN cord-010119-t1x9gknd 4296 9 . . . cord-010119-t1x9gknd 4297 1 Results/ Results/ . cord-010119-t1x9gknd 4298 1 Findings finding NNS cord-010119-t1x9gknd 4298 2 : : : cord-010119-t1x9gknd 4298 3 Platelet platelet NN cord-010119-t1x9gknd 4298 4 count count NN cord-010119-t1x9gknd 4298 5 began begin VBD cord-010119-t1x9gknd 4298 6 to to TO cord-010119-t1x9gknd 4298 7 increase increase VB cord-010119-t1x9gknd 4298 8 prior prior RB cord-010119-t1x9gknd 4298 9 to to IN cord-010119-t1x9gknd 4298 10 TPE TPE NNP cord-010119-t1x9gknd 4298 11 initiation initiation NN cord-010119-t1x9gknd 4298 12 ( ( -LRB- cord-010119-t1x9gknd 4298 13 74 74 CD cord-010119-t1x9gknd 4298 14 x x SYM cord-010119-t1x9gknd 4298 15 10 10 CD cord-010119-t1x9gknd 4298 16 9 9 CD cord-010119-t1x9gknd 4298 17 /L /L . cord-010119-t1x9gknd 4298 18 and and CC cord-010119-t1x9gknd 4298 19 A A NNP cord-010119-t1x9gknd 4298 20 - - HYPH cord-010119-t1x9gknd 4298 21 IPC IPC NNP cord-010119-t1x9gknd 4298 22 of of IN cord-010119-t1x9gknd 4298 23 4.7 4.7 CD cord-010119-t1x9gknd 4298 24 x x SYM cord-010119-t1x9gknd 4298 25 10 10 CD cord-010119-t1x9gknd 4298 26 9 9 CD cord-010119-t1x9gknd 4298 27 /L /l CD cord-010119-t1x9gknd 4298 28 ) ) -RRB- cord-010119-t1x9gknd 4298 29 . . . cord-010119-t1x9gknd 4299 1 Two two CD cord-010119-t1x9gknd 4299 2 consecutive consecutive JJ cord-010119-t1x9gknd 4299 3 TPE tpe NN cord-010119-t1x9gknd 4299 4 were be VBD cord-010119-t1x9gknd 4299 5 completed complete VBN cord-010119-t1x9gknd 4299 6 which which WDT cord-010119-t1x9gknd 4299 7 resulted result VBD cord-010119-t1x9gknd 4299 8 in in IN cord-010119-t1x9gknd 4299 9 a a DT cord-010119-t1x9gknd 4299 10 platelet platelet NN cord-010119-t1x9gknd 4299 11 count count NN cord-010119-t1x9gknd 4299 12 decrease decrease NN cord-010119-t1x9gknd 4299 13 to to IN cord-010119-t1x9gknd 4299 14 54 54 CD cord-010119-t1x9gknd 4299 15 x x SYM cord-010119-t1x9gknd 4299 16 10 10 CD cord-010119-t1x9gknd 4299 17 9 9 CD cord-010119-t1x9gknd 4299 18 /L /L . cord-010119-t1x9gknd 4299 19 and and CC cord-010119-t1x9gknd 4299 20 A A NNP cord-010119-t1x9gknd 4299 21 - - HYPH cord-010119-t1x9gknd 4299 22 IPC IPC NNP cord-010119-t1x9gknd 4299 23 of of IN cord-010119-t1x9gknd 4299 24 5.1 5.1 CD cord-010119-t1x9gknd 4299 25 x x SYM cord-010119-t1x9gknd 4299 26 10 10 CD cord-010119-t1x9gknd 4299 27 9 9 CD cord-010119-t1x9gknd 4300 1 /L. /L. . cord-010119-t1x9gknd 4301 1 A a LS cord-010119-t1x9gknd 4301 2 - - HYPH cord-010119-t1x9gknd 4301 3 IPC IPC NNP cord-010119-t1x9gknd 4301 4 ratio ratio NN cord-010119-t1x9gknd 4301 5 was be VBD cord-010119-t1x9gknd 4301 6 1.1 1.1 CD cord-010119-t1x9gknd 4301 7 below below IN cord-010119-t1x9gknd 4301 8 the the DT cord-010119-t1x9gknd 4301 9 ratio ratio NN cord-010119-t1x9gknd 4301 10 of of IN cord-010119-t1x9gknd 4301 11 3 3 CD cord-010119-t1x9gknd 4301 12 which which WDT cord-010119-t1x9gknd 4301 13 has have VBZ cord-010119-t1x9gknd 4301 14 been be VBN cord-010119-t1x9gknd 4301 15 reported report VBN cord-010119-t1x9gknd 4301 16 for for IN cord-010119-t1x9gknd 4301 17 TTP TTP NNP cord-010119-t1x9gknd 4301 18 patients patient NNS cord-010119-t1x9gknd 4301 19 . . . cord-010119-t1x9gknd 4302 1 Similarly similarly RB cord-010119-t1x9gknd 4302 2 A A NNP cord-010119-t1x9gknd 4302 3 - - HYPH cord-010119-t1x9gknd 4302 4 IPC IPC NNP cord-010119-t1x9gknd 4302 5 count count NN cord-010119-t1x9gknd 4302 6 was be VBD cord-010119-t1x9gknd 4302 7 not not RB cord-010119-t1x9gknd 4302 8 below below IN cord-010119-t1x9gknd 4302 9 5 5 CD cord-010119-t1x9gknd 4302 10 x x SYM cord-010119-t1x9gknd 4302 11 10 10 CD cord-010119-t1x9gknd 4302 12 9 9 CD cord-010119-t1x9gknd 4302 13 /L /l CD cord-010119-t1x9gknd 4302 14 threshold threshold NN cord-010119-t1x9gknd 4302 15 reported report VBN cord-010119-t1x9gknd 4302 16 in in IN cord-010119-t1x9gknd 4302 17 setting setting NN cord-010119-t1x9gknd 4302 18 of of IN cord-010119-t1x9gknd 4302 19 TTP ttp NN cord-010119-t1x9gknd 4302 20 with with IN cord-010119-t1x9gknd 4302 21 severe severe JJ cord-010119-t1x9gknd 4302 22 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4302 23 deficiency deficiency NN cord-010119-t1x9gknd 4302 24 . . . cord-010119-t1x9gknd 4303 1 At at IN cord-010119-t1x9gknd 4303 2 this this DT cord-010119-t1x9gknd 4303 3 time time NN cord-010119-t1x9gknd 4303 4 stool stool NN cord-010119-t1x9gknd 4303 5 culture culture NN cord-010119-t1x9gknd 4303 6 obtained obtain VBN cord-010119-t1x9gknd 4303 7 prior prior RB cord-010119-t1x9gknd 4303 8 to to IN cord-010119-t1x9gknd 4303 9 start start NN cord-010119-t1x9gknd 4303 10 of of IN cord-010119-t1x9gknd 4303 11 TPE TPE NNP cord-010119-t1x9gknd 4303 12 came come VBD cord-010119-t1x9gknd 4303 13 back back RB cord-010119-t1x9gknd 4303 14 positive positive JJ cord-010119-t1x9gknd 4303 15 for for IN cord-010119-t1x9gknd 4303 16 E. E. NNP cord-010119-t1x9gknd 4303 17 coli coli NNS cord-010119-t1x9gknd 4303 18 O157 O157 NNP cord-010119-t1x9gknd 4303 19 : : : cord-010119-t1x9gknd 4304 1 H7 H7 NNP cord-010119-t1x9gknd 4304 2 toxin toxin NN cord-010119-t1x9gknd 4304 3 . . . cord-010119-t1x9gknd 4305 1 Testing testing NN cord-010119-t1x9gknd 4305 2 of of IN cord-010119-t1x9gknd 4305 3 C3 C3 NNP cord-010119-t1x9gknd 4305 4 , , , cord-010119-t1x9gknd 4305 5 C4 C4 NNP cord-010119-t1x9gknd 4305 6 , , , cord-010119-t1x9gknd 4305 7 Factor Factor NNP cord-010119-t1x9gknd 4305 8 H H NNP cord-010119-t1x9gknd 4305 9 , , , cord-010119-t1x9gknd 4305 10 Factor factor NN cord-010119-t1x9gknd 4305 11 H H NNP cord-010119-t1x9gknd 4305 12 autoantibody autoantibody NN cord-010119-t1x9gknd 4305 13 , , , cord-010119-t1x9gknd 4306 1 Factor factor NN cord-010119-t1x9gknd 4306 2 I I NNP cord-010119-t1x9gknd 4306 3 and and CC cord-010119-t1x9gknd 4306 4 Factor Factor NNP cord-010119-t1x9gknd 4306 5 B B NNP cord-010119-t1x9gknd 4306 6 were be VBD cord-010119-t1x9gknd 4306 7 normal normal JJ cord-010119-t1x9gknd 4306 8 . . . cord-010119-t1x9gknd 4307 1 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4307 2 activity activity NN cord-010119-t1x9gknd 4307 3 was be VBD cord-010119-t1x9gknd 4307 4 93 93 CD cord-010119-t1x9gknd 4307 5 % % NN cord-010119-t1x9gknd 4307 6 . . . cord-010119-t1x9gknd 4308 1 Patient Patient NNP cord-010119-t1x9gknd 4308 2 was be VBD cord-010119-t1x9gknd 4308 3 treated treat VBN cord-010119-t1x9gknd 4308 4 for for IN cord-010119-t1x9gknd 4308 5 the the DT cord-010119-t1x9gknd 4308 6 infection infection NN cord-010119-t1x9gknd 4308 7 and and CC cord-010119-t1x9gknd 4308 8 platelet platelet NN cord-010119-t1x9gknd 4308 9 count count NN cord-010119-t1x9gknd 4308 10 improved improve VBD cord-010119-t1x9gknd 4308 11 within within IN cord-010119-t1x9gknd 4308 12 10 10 CD cord-010119-t1x9gknd 4308 13 days day NNS cord-010119-t1x9gknd 4308 14 to to IN cord-010119-t1x9gknd 4308 15 315 315 CD cord-010119-t1x9gknd 4308 16 x x SYM cord-010119-t1x9gknd 4308 17 10 10 CD cord-010119-t1x9gknd 4308 18 9 9 CD cord-010119-t1x9gknd 4308 19 /L /l CD cord-010119-t1x9gknd 4308 20 , , , cord-010119-t1x9gknd 4308 21 with with IN cord-010119-t1x9gknd 4308 22 resolution resolution NN cord-010119-t1x9gknd 4308 23 of of IN cord-010119-t1x9gknd 4308 24 her -PRON- PRP$ cord-010119-t1x9gknd 4308 25 renal renal JJ cord-010119-t1x9gknd 4308 26 failure failure NN cord-010119-t1x9gknd 4308 27 : : : cord-010119-t1x9gknd 4308 28 BUN bun NN cord-010119-t1x9gknd 4308 29 : : : cord-010119-t1x9gknd 4308 30 42 42 CD cord-010119-t1x9gknd 4308 31 mg mg NNP cord-010119-t1x9gknd 4308 32 / / SYM cord-010119-t1x9gknd 4308 33 dL dl NN cord-010119-t1x9gknd 4309 1 , , , cord-010119-t1x9gknd 4309 2 creatinine creatinine NN cord-010119-t1x9gknd 4309 3 : : : cord-010119-t1x9gknd 4309 4 0.65 0.65 CD cord-010119-t1x9gknd 4309 5 mg/ mg/ NN cord-010119-t1x9gknd 4310 1 dL. dL. NNP cord-010119-t1x9gknd 4311 1 No no DT cord-010119-t1x9gknd 4311 2 additional additional JJ cord-010119-t1x9gknd 4311 3 seizures seizure NNS cord-010119-t1x9gknd 4311 4 were be VBD cord-010119-t1x9gknd 4311 5 observed observe VBN cord-010119-t1x9gknd 4311 6 during during IN cord-010119-t1x9gknd 4311 7 follow follow NN cord-010119-t1x9gknd 4311 8 - - HYPH cord-010119-t1x9gknd 4311 9 up up NN cord-010119-t1x9gknd 4311 10 . . . cord-010119-t1x9gknd 4312 1 Conclusion conclusion NN cord-010119-t1x9gknd 4312 2 : : : cord-010119-t1x9gknd 4312 3 Measurement measurement NN cord-010119-t1x9gknd 4312 4 of of IN cord-010119-t1x9gknd 4312 5 A A NNP cord-010119-t1x9gknd 4312 6 - - HYPH cord-010119-t1x9gknd 4312 7 IPC IPC NNP cord-010119-t1x9gknd 4312 8 can can MD cord-010119-t1x9gknd 4312 9 be be VB cord-010119-t1x9gknd 4312 10 used use VBN cord-010119-t1x9gknd 4312 11 to to TO cord-010119-t1x9gknd 4312 12 aid aid VB cord-010119-t1x9gknd 4312 13 clinical clinical JJ cord-010119-t1x9gknd 4312 14 decisions decision NNS cord-010119-t1x9gknd 4312 15 in in IN cord-010119-t1x9gknd 4312 16 pediatric pediatric JJ cord-010119-t1x9gknd 4312 17 patients patient NNS cord-010119-t1x9gknd 4312 18 suspected suspect VBN cord-010119-t1x9gknd 4312 19 of of IN cord-010119-t1x9gknd 4312 20 TTP TTP NNP cord-010119-t1x9gknd 4312 21 especially especially RB cord-010119-t1x9gknd 4312 22 when when WRB cord-010119-t1x9gknd 4312 23 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4312 24 testing testing NN cord-010119-t1x9gknd 4312 25 and and CC cord-010119-t1x9gknd 4312 26 those those DT cord-010119-t1x9gknd 4312 27 for for IN cord-010119-t1x9gknd 4312 28 other other JJ cord-010119-t1x9gknd 4312 29 etiologies etiology NNS cord-010119-t1x9gknd 4312 30 are be VBP cord-010119-t1x9gknd 4312 31 still still RB cord-010119-t1x9gknd 4312 32 pending pende VBG cord-010119-t1x9gknd 4312 33 . . . cord-010119-t1x9gknd 4313 1 TPE TPE NNP cord-010119-t1x9gknd 4313 2 did do VBD cord-010119-t1x9gknd 4313 3 not not RB cord-010119-t1x9gknd 4313 4 seem seem VB cord-010119-t1x9gknd 4313 5 to to TO cord-010119-t1x9gknd 4313 6 have have VB cord-010119-t1x9gknd 4313 7 a a DT cord-010119-t1x9gknd 4313 8 significant significant JJ cord-010119-t1x9gknd 4313 9 effect effect NN cord-010119-t1x9gknd 4313 10 in in IN cord-010119-t1x9gknd 4313 11 A A NNP cord-010119-t1x9gknd 4313 12 - - HYPH cord-010119-t1x9gknd 4313 13 IPC IPC NNP cord-010119-t1x9gknd 4313 14 but but CC cord-010119-t1x9gknd 4313 15 decreased decrease VBD cord-010119-t1x9gknd 4313 16 platelet platelet NN cord-010119-t1x9gknd 4313 17 counts count NNS cord-010119-t1x9gknd 4313 18 in in IN cord-010119-t1x9gknd 4313 19 this this DT cord-010119-t1x9gknd 4313 20 patient patient NN cord-010119-t1x9gknd 4313 21 . . . cord-010119-t1x9gknd 4314 1 A a LS cord-010119-t1x9gknd 4314 2 - - HYPH cord-010119-t1x9gknd 4314 3 IPC IPC NNP cord-010119-t1x9gknd 4314 4 is be VBZ cord-010119-t1x9gknd 4314 5 rapid rapid JJ cord-010119-t1x9gknd 4314 6 to to TO cord-010119-t1x9gknd 4314 7 obtain obtain VB cord-010119-t1x9gknd 4314 8 and and CC cord-010119-t1x9gknd 4314 9 can can MD cord-010119-t1x9gknd 4314 10 provide provide VB cord-010119-t1x9gknd 4314 11 helpful helpful JJ cord-010119-t1x9gknd 4314 12 information information NN cord-010119-t1x9gknd 4314 13 in in IN cord-010119-t1x9gknd 4314 14 the the DT cord-010119-t1x9gknd 4314 15 setting setting NN cord-010119-t1x9gknd 4314 16 of of IN cord-010119-t1x9gknd 4314 17 potentially potentially RB cord-010119-t1x9gknd 4314 18 overlapping overlapping JJ cord-010119-t1x9gknd 4314 19 etiologies etiology NNS cord-010119-t1x9gknd 4314 20 in in IN cord-010119-t1x9gknd 4314 21 the the DT cord-010119-t1x9gknd 4314 22 setting setting NN cord-010119-t1x9gknd 4314 23 of of IN cord-010119-t1x9gknd 4314 24 other other JJ cord-010119-t1x9gknd 4314 25 testing testing NN cord-010119-t1x9gknd 4314 26 with with IN cord-010119-t1x9gknd 4314 27 longer long JJR cord-010119-t1x9gknd 4314 28 turnaround turnaround NN cord-010119-t1x9gknd 4314 29 time time NN cord-010119-t1x9gknd 4314 30 . . . cord-010119-t1x9gknd 4315 1 Background Background NNP cord-010119-t1x9gknd 4315 2 / / SYM cord-010119-t1x9gknd 4315 3 Case Case NNP cord-010119-t1x9gknd 4315 4 Studies Studies NNPS cord-010119-t1x9gknd 4315 5 : : : cord-010119-t1x9gknd 4315 6 Thrombotic thrombotic JJ cord-010119-t1x9gknd 4315 7 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 4315 8 purpura purpura NN cord-010119-t1x9gknd 4315 9 ( ( -LRB- cord-010119-t1x9gknd 4315 10 TTP TTP NNP cord-010119-t1x9gknd 4315 11 ) ) -RRB- cord-010119-t1x9gknd 4315 12 is be VBZ cord-010119-t1x9gknd 4315 13 a a DT cord-010119-t1x9gknd 4315 14 thrombotic thrombotic JJ cord-010119-t1x9gknd 4315 15 microangiopathy microangiopathy NN cord-010119-t1x9gknd 4315 16 characterized characterize VBN cord-010119-t1x9gknd 4315 17 by by IN cord-010119-t1x9gknd 4315 18 low low JJ cord-010119-t1x9gknd 4315 19 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4315 20 activity activity NN cord-010119-t1x9gknd 4315 21 . . . cord-010119-t1x9gknd 4316 1 Many many JJ cord-010119-t1x9gknd 4316 2 patients patient NNS cord-010119-t1x9gknd 4316 3 with with IN cord-010119-t1x9gknd 4316 4 severe severe JJ cord-010119-t1x9gknd 4316 5 autoantibody autoantibody NN cord-010119-t1x9gknd 4316 6 - - HYPH cord-010119-t1x9gknd 4316 7 mediated mediate VBN cord-010119-t1x9gknd 4316 8 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4316 9 deficiency deficiency NN cord-010119-t1x9gknd 4316 10 at at IN cord-010119-t1x9gknd 4316 11 initial initial JJ cord-010119-t1x9gknd 4316 12 disease disease NN cord-010119-t1x9gknd 4316 13 presentation presentation NN cord-010119-t1x9gknd 4316 14 may may MD cord-010119-t1x9gknd 4316 15 suffer suffer VB cord-010119-t1x9gknd 4316 16 from from IN cord-010119-t1x9gknd 4316 17 one one CD cord-010119-t1x9gknd 4316 18 or or CC cord-010119-t1x9gknd 4316 19 more more JJR cord-010119-t1x9gknd 4316 20 recurrent recurrent JJ cord-010119-t1x9gknd 4316 21 episodes episode NNS cord-010119-t1x9gknd 4316 22 over over IN cord-010119-t1x9gknd 4316 23 the the DT cord-010119-t1x9gknd 4316 24 following following JJ cord-010119-t1x9gknd 4316 25 months month NNS cord-010119-t1x9gknd 4316 26 or or CC cord-010119-t1x9gknd 4316 27 years year NNS cord-010119-t1x9gknd 4316 28 . . . cord-010119-t1x9gknd 4317 1 It -PRON- PRP cord-010119-t1x9gknd 4317 2 is be VBZ cord-010119-t1x9gknd 4317 3 unclear unclear JJ cord-010119-t1x9gknd 4317 4 if if IN cord-010119-t1x9gknd 4317 5 disease disease NN cord-010119-t1x9gknd 4317 6 course course NN cord-010119-t1x9gknd 4317 7 and and CC cord-010119-t1x9gknd 4317 8 characteristics characteristic NNS cord-010119-t1x9gknd 4317 9 of of IN cord-010119-t1x9gknd 4317 10 recurrent recurrent JJ cord-010119-t1x9gknd 4317 11 / / SYM cord-010119-t1x9gknd 4317 12 relapsed relapse VBN cord-010119-t1x9gknd 4317 13 TTP TTP NNP cord-010119-t1x9gknd 4317 14 may may MD cord-010119-t1x9gknd 4317 15 be be VB cord-010119-t1x9gknd 4317 16 different different JJ cord-010119-t1x9gknd 4317 17 from from IN cord-010119-t1x9gknd 4317 18 that that DT cord-010119-t1x9gknd 4317 19 seen see VBN cord-010119-t1x9gknd 4317 20 at at IN cord-010119-t1x9gknd 4317 21 initial initial JJ cord-010119-t1x9gknd 4317 22 presentation presentation NN cord-010119-t1x9gknd 4317 23 . . . cord-010119-t1x9gknd 4318 1 Since since IN cord-010119-t1x9gknd 4318 2 absolute absolute JJ cord-010119-t1x9gknd 4318 3 immature immature JJ cord-010119-t1x9gknd 4318 4 platelet platelet NN cord-010119-t1x9gknd 4318 5 counts count NNS cord-010119-t1x9gknd 4318 6 ( ( -LRB- cord-010119-t1x9gknd 4318 7 A A NNP cord-010119-t1x9gknd 4318 8 - - HYPH cord-010119-t1x9gknd 4318 9 IPC IPC NNP cord-010119-t1x9gknd 4318 10 ) ) -RRB- cord-010119-t1x9gknd 4318 11 have have VBP cord-010119-t1x9gknd 4318 12 been be VBN cord-010119-t1x9gknd 4318 13 shown show VBN cord-010119-t1x9gknd 4318 14 to to TO cord-010119-t1x9gknd 4318 15 be be VB cord-010119-t1x9gknd 4318 16 useful useful JJ cord-010119-t1x9gknd 4318 17 in in IN cord-010119-t1x9gknd 4318 18 the the DT cord-010119-t1x9gknd 4318 19 diagnosis diagnosis NN cord-010119-t1x9gknd 4318 20 and and CC cord-010119-t1x9gknd 4318 21 to to TO cord-010119-t1x9gknd 4318 22 follow follow VB cord-010119-t1x9gknd 4318 23 response response NN cord-010119-t1x9gknd 4318 24 to to IN cord-010119-t1x9gknd 4318 25 therapy therapy NN cord-010119-t1x9gknd 4318 26 of of IN cord-010119-t1x9gknd 4318 27 TTP TTP NNP cord-010119-t1x9gknd 4318 28 patients patient NNS cord-010119-t1x9gknd 4318 29 , , , cord-010119-t1x9gknd 4318 30 we -PRON- PRP cord-010119-t1x9gknd 4318 31 proceeded proceed VBD cord-010119-t1x9gknd 4318 32 to to TO cord-010119-t1x9gknd 4318 33 evaluate evaluate VB cord-010119-t1x9gknd 4318 34 if if IN cord-010119-t1x9gknd 4318 35 A A NNP cord-010119-t1x9gknd 4318 36 - - HYPH cord-010119-t1x9gknd 4318 37 IPC IPC NNP cord-010119-t1x9gknd 4318 38 pattern pattern NN cord-010119-t1x9gknd 4318 39 was be VBD cord-010119-t1x9gknd 4318 40 different different JJ cord-010119-t1x9gknd 4318 41 in in IN cord-010119-t1x9gknd 4318 42 relapsed relapsed JJ cord-010119-t1x9gknd 4318 43 verse verse NN cord-010119-t1x9gknd 4318 44 initial initial JJ cord-010119-t1x9gknd 4318 45 presentation presentation NN cord-010119-t1x9gknd 4318 46 . . . cord-010119-t1x9gknd 4319 1 Study Study NNP cord-010119-t1x9gknd 4319 2 Design Design NNP cord-010119-t1x9gknd 4319 3 / / SYM cord-010119-t1x9gknd 4319 4 Methods method NNS cord-010119-t1x9gknd 4320 1 : : : cord-010119-t1x9gknd 4320 2 Our -PRON- PRP$ cord-010119-t1x9gknd 4320 3 study study NN cord-010119-t1x9gknd 4320 4 cohort cohort NN cord-010119-t1x9gknd 4320 5 consisted consist VBD cord-010119-t1x9gknd 4320 6 of of IN cord-010119-t1x9gknd 4320 7 three three CD cord-010119-t1x9gknd 4320 8 patients patient NNS cord-010119-t1x9gknd 4320 9 ( ( -LRB- cord-010119-t1x9gknd 4320 10 two two CD cord-010119-t1x9gknd 4320 11 female female JJ cord-010119-t1x9gknd 4320 12 and and CC cord-010119-t1x9gknd 4320 13 one one CD cord-010119-t1x9gknd 4320 14 male male NN cord-010119-t1x9gknd 4320 15 ) ) -RRB- cord-010119-t1x9gknd 4320 16 with with IN cord-010119-t1x9gknd 4320 17 acquired acquire VBN cord-010119-t1x9gknd 4320 18 TTP TTP NNP cord-010119-t1x9gknd 4320 19 ( ( -LRB- cord-010119-t1x9gknd 4320 20 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4320 21 activity activity NN cord-010119-t1x9gknd 4320 22 < < XX cord-010119-t1x9gknd 4320 23 5 5 CD cord-010119-t1x9gknd 4320 24 % % NN cord-010119-t1x9gknd 4320 25 ) ) -RRB- cord-010119-t1x9gknd 4320 26 who who WP cord-010119-t1x9gknd 4320 27 underwent undergo VBD cord-010119-t1x9gknd 4320 28 daily daily JJ cord-010119-t1x9gknd 4320 29 therapeutic therapeutic JJ cord-010119-t1x9gknd 4320 30 plasma plasma NN cord-010119-t1x9gknd 4320 31 exchange exchange NN cord-010119-t1x9gknd 4320 32 ( ( -LRB- cord-010119-t1x9gknd 4320 33 TPE TPE NNP cord-010119-t1x9gknd 4320 34 ) ) -RRB- cord-010119-t1x9gknd 4320 35 . . . cord-010119-t1x9gknd 4321 1 Clinical clinical JJ cord-010119-t1x9gknd 4321 2 course course NN cord-010119-t1x9gknd 4321 3 and and CC cord-010119-t1x9gknd 4321 4 laboratory laboratory NN cord-010119-t1x9gknd 4321 5 values value NNS cord-010119-t1x9gknd 4321 6 were be VBD cord-010119-t1x9gknd 4321 7 reviewed review VBN cord-010119-t1x9gknd 4321 8 . . . cord-010119-t1x9gknd 4322 1 Platelet platelet NN cord-010119-t1x9gknd 4322 2 count count NN cord-010119-t1x9gknd 4322 3 ( ( -LRB- cord-010119-t1x9gknd 4322 4 PLT PLT NNP cord-010119-t1x9gknd 4322 5 ) ) -RRB- cord-010119-t1x9gknd 4322 6 , , , cord-010119-t1x9gknd 4322 7 immature immature JJ cord-010119-t1x9gknd 4322 8 platelet platelet NN cord-010119-t1x9gknd 4322 9 fraction fraction NN cord-010119-t1x9gknd 4322 10 ( ( -LRB- cord-010119-t1x9gknd 4322 11 % % NN cord-010119-t1x9gknd 4322 12 -IPF -ipf CD cord-010119-t1x9gknd 4322 13 ) ) -RRB- cord-010119-t1x9gknd 4322 14 and and CC cord-010119-t1x9gknd 4322 15 A A NNP cord-010119-t1x9gknd 4322 16 - - HYPH cord-010119-t1x9gknd 4322 17 IPC IPC NNP cord-010119-t1x9gknd 4322 18 ( ( -LRB- cord-010119-t1x9gknd 4322 19 % % NN cord-010119-t1x9gknd 4322 20 -IPF -ipf SYM cord-010119-t1x9gknd 4322 21 x x SYM cord-010119-t1x9gknd 4322 22 platelet platelet NN cord-010119-t1x9gknd 4322 23 count count NN cord-010119-t1x9gknd 4322 24 ) ) -RRB- cord-010119-t1x9gknd 4322 25 were be VBD cord-010119-t1x9gknd 4322 26 analyzed analyze VBN cord-010119-t1x9gknd 4322 27 during during IN cord-010119-t1x9gknd 4322 28 treatment treatment NN cord-010119-t1x9gknd 4322 29 course course NN cord-010119-t1x9gknd 4322 30 . . . cord-010119-t1x9gknd 4323 1 A a LS cord-010119-t1x9gknd 4323 2 - - HYPH cord-010119-t1x9gknd 4323 3 IPC IPC NNP cord-010119-t1x9gknd 4323 4 values value NNS cord-010119-t1x9gknd 4323 5 at at IN cord-010119-t1x9gknd 4323 6 presentation presentation NN cord-010119-t1x9gknd 4323 7 and and CC cord-010119-t1x9gknd 4323 8 peak peak NN cord-010119-t1x9gknd 4323 9 , , , cord-010119-t1x9gknd 4323 10 A A NNP cord-010119-t1x9gknd 4323 11 - - HYPH cord-010119-t1x9gknd 4323 12 IPC IPC NNP cord-010119-t1x9gknd 4323 13 peak peak NN cord-010119-t1x9gknd 4323 14 time time NN cord-010119-t1x9gknd 4323 15 ( ( -LRB- cord-010119-t1x9gknd 4323 16 days day NNS cord-010119-t1x9gknd 4323 17 ) ) -RRB- cord-010119-t1x9gknd 4323 18 , , , cord-010119-t1x9gknd 4323 19 and and CC cord-010119-t1x9gknd 4323 20 PLT PLT NNP cord-010119-t1x9gknd 4323 21 count count NN cord-010119-t1x9gknd 4323 22 recovery recovery NN cord-010119-t1x9gknd 4323 23 time time NN cord-010119-t1x9gknd 4323 24 ( ( -LRB- cord-010119-t1x9gknd 4323 25 days day NNS cord-010119-t1x9gknd 4323 26 ) ) -RRB- cord-010119-t1x9gknd 4323 27 were be VBD cord-010119-t1x9gknd 4323 28 compared compare VBN cord-010119-t1x9gknd 4323 29 between between IN cord-010119-t1x9gknd 4323 30 initial initial JJ cord-010119-t1x9gknd 4323 31 onset onset NN cord-010119-t1x9gknd 4323 32 and and CC cord-010119-t1x9gknd 4323 33 relapse relapse NN cord-010119-t1x9gknd 4323 34 episode episode NN cord-010119-t1x9gknd 4323 35 for for IN cord-010119-t1x9gknd 4323 36 each each DT cord-010119-t1x9gknd 4323 37 patient patient NN cord-010119-t1x9gknd 4323 38 . . . cord-010119-t1x9gknd 4324 1 A a LS cord-010119-t1x9gknd 4324 2 - - HYPH cord-010119-t1x9gknd 4324 3 IPC IPC NNP cord-010119-t1x9gknd 4324 4 percent percent NN cord-010119-t1x9gknd 4324 5 change change NN cord-010119-t1x9gknd 4324 6 in in IN cord-010119-t1x9gknd 4324 7 relapse relapse NN cord-010119-t1x9gknd 4324 8 episodes episode NNS cord-010119-t1x9gknd 4324 9 compared compare VBN cord-010119-t1x9gknd 4324 10 to to IN cord-010119-t1x9gknd 4324 11 initial initial JJ cord-010119-t1x9gknd 4324 12 presentation presentation NN cord-010119-t1x9gknd 4324 13 was be VBD cord-010119-t1x9gknd 4324 14 calculated calculate VBN cord-010119-t1x9gknd 4324 15 . . . cord-010119-t1x9gknd 4325 1 Results result NNS cord-010119-t1x9gknd 4325 2 / / SYM cord-010119-t1x9gknd 4325 3 Findings finding NNS cord-010119-t1x9gknd 4325 4 : : : cord-010119-t1x9gknd 4326 1 All all DT cord-010119-t1x9gknd 4326 2 patients patient NNS cord-010119-t1x9gknd 4326 3 had have VBD cord-010119-t1x9gknd 4326 4 an an DT cord-010119-t1x9gknd 4326 5 increased increase VBN cord-010119-t1x9gknd 4326 6 % % NN cord-010119-t1x9gknd 4326 7 -IPF -ipf NN cord-010119-t1x9gknd 4326 8 , , , cord-010119-t1x9gknd 4326 9 and and CC cord-010119-t1x9gknd 4326 10 decreased decrease VBD cord-010119-t1x9gknd 4326 11 A A NNP cord-010119-t1x9gknd 4326 12 - - HYPH cord-010119-t1x9gknd 4326 13 IPC IPC NNP cord-010119-t1x9gknd 4326 14 and and CC cord-010119-t1x9gknd 4326 15 PLT PLT NNP cord-010119-t1x9gknd 4326 16 count count NN cord-010119-t1x9gknd 4326 17 at at IN cord-010119-t1x9gknd 4326 18 presentation presentation NN cord-010119-t1x9gknd 4326 19 in in IN cord-010119-t1x9gknd 4326 20 both both CC cord-010119-t1x9gknd 4326 21 initial initial JJ cord-010119-t1x9gknd 4326 22 and and CC cord-010119-t1x9gknd 4326 23 recurrent recurrent JJ cord-010119-t1x9gknd 4326 24 episodes episode NNS cord-010119-t1x9gknd 4326 25 . . . cord-010119-t1x9gknd 4327 1 Once once IN cord-010119-t1x9gknd 4327 2 TPE TPE NNP cord-010119-t1x9gknd 4327 3 treatment treatment NN cord-010119-t1x9gknd 4327 4 was be VBD cord-010119-t1x9gknd 4327 5 initiated initiate VBN cord-010119-t1x9gknd 4327 6 , , , cord-010119-t1x9gknd 4327 7 A A NNP cord-010119-t1x9gknd 4327 8 - - HYPH cord-010119-t1x9gknd 4327 9 IPC IPC NNP cord-010119-t1x9gknd 4327 10 rapidly rapidly RB cord-010119-t1x9gknd 4327 11 increased increase VBD cord-010119-t1x9gknd 4327 12 and and CC cord-010119-t1x9gknd 4327 13 reached reach VBD cord-010119-t1x9gknd 4327 14 a a DT cord-010119-t1x9gknd 4327 15 peak peak NN cord-010119-t1x9gknd 4327 16 value value NN cord-010119-t1x9gknd 4327 17 2 2 CD cord-010119-t1x9gknd 4327 18 - - SYM cord-010119-t1x9gknd 4327 19 3 3 CD cord-010119-t1x9gknd 4327 20 days day NNS cord-010119-t1x9gknd 4327 21 prior prior RB cord-010119-t1x9gknd 4327 22 to to IN cord-010119-t1x9gknd 4327 23 PLT PLT NNP cord-010119-t1x9gknd 4327 24 count count NN cord-010119-t1x9gknd 4327 25 recovery recovery NN cord-010119-t1x9gknd 4327 26 , , , cord-010119-t1x9gknd 4327 27 consistent consistent JJ cord-010119-t1x9gknd 4327 28 with with IN cord-010119-t1x9gknd 4327 29 that that DT cord-010119-t1x9gknd 4327 30 previously previously RB cord-010119-t1x9gknd 4327 31 described describe VBN cord-010119-t1x9gknd 4327 32 in in IN cord-010119-t1x9gknd 4327 33 TTP TTP NNP cord-010119-t1x9gknd 4327 34 patients patient NNS cord-010119-t1x9gknd 4327 35 . . . cord-010119-t1x9gknd 4328 1 However however RB cord-010119-t1x9gknd 4328 2 , , , cord-010119-t1x9gknd 4328 3 compared compare VBN cord-010119-t1x9gknd 4328 4 to to IN cord-010119-t1x9gknd 4328 5 first first JJ cord-010119-t1x9gknd 4328 6 onset onset NN cord-010119-t1x9gknd 4328 7 , , , cord-010119-t1x9gknd 4328 8 recurrent recurrent JJ cord-010119-t1x9gknd 4328 9 episodes episode NNS cord-010119-t1x9gknd 4328 10 featured feature VBD cord-010119-t1x9gknd 4328 11 lower low JJR cord-010119-t1x9gknd 4328 12 A A NNP cord-010119-t1x9gknd 4328 13 - - HYPH cord-010119-t1x9gknd 4328 14 IPC IPC NNP cord-010119-t1x9gknd 4328 15 at at IN cord-010119-t1x9gknd 4328 16 presentation presentation NN cord-010119-t1x9gknd 4328 17 ( ( -LRB- cord-010119-t1x9gknd 4328 18 results result NNS cord-010119-t1x9gknd 4328 19 shown show VBN cord-010119-t1x9gknd 4328 20 as as IN cord-010119-t1x9gknd 4328 21 percent percent NN cord-010119-t1x9gknd 4328 22 decrease decrease NN cord-010119-t1x9gknd 4328 23 , , , cord-010119-t1x9gknd 4328 24 column column NN cord-010119-t1x9gknd 4328 25 1 1 CD cord-010119-t1x9gknd 4328 26 ) ) -RRB- cord-010119-t1x9gknd 4328 27 , , , cord-010119-t1x9gknd 4328 28 increased increase VBN cord-010119-t1x9gknd 4328 29 peak peak NNP cord-010119-t1x9gknd 4328 30 A A NNP cord-010119-t1x9gknd 4328 31 - - HYPH cord-010119-t1x9gknd 4328 32 IPC IPC NNP cord-010119-t1x9gknd 4328 33 value value NN cord-010119-t1x9gknd 4328 34 ( ( -LRB- cord-010119-t1x9gknd 4328 35 results result NNS cord-010119-t1x9gknd 4328 36 shown show VBN cord-010119-t1x9gknd 4328 37 as as IN cord-010119-t1x9gknd 4328 38 percent percent NN cord-010119-t1x9gknd 4328 39 increase increase NN cord-010119-t1x9gknd 4328 40 , , , cord-010119-t1x9gknd 4328 41 column column NN cord-010119-t1x9gknd 4328 42 2 2 CD cord-010119-t1x9gknd 4328 43 ) ) -RRB- cord-010119-t1x9gknd 4328 44 , , , cord-010119-t1x9gknd 4328 45 delayed delay VBD cord-010119-t1x9gknd 4328 46 A A NNP cord-010119-t1x9gknd 4328 47 - - HYPH cord-010119-t1x9gknd 4328 48 IPC IPC NNP cord-010119-t1x9gknd 4328 49 peak peak NN cord-010119-t1x9gknd 4328 50 , , , cord-010119-t1x9gknd 4328 51 and and CC cord-010119-t1x9gknd 4328 52 delayed delay VBD cord-010119-t1x9gknd 4328 53 PLT PLT NNP cord-010119-t1x9gknd 4328 54 recovery recovery NN cord-010119-t1x9gknd 4328 55 ( ( -LRB- cord-010119-t1x9gknd 4328 56 Table table NN cord-010119-t1x9gknd 4328 57 _SP cord-010119-t1x9gknd 4328 58 1 1 CD cord-010119-t1x9gknd 4328 59 ) ) -RRB- cord-010119-t1x9gknd 4328 60 . . . cord-010119-t1x9gknd 4329 1 Moreover moreover RB cord-010119-t1x9gknd 4329 2 , , , cord-010119-t1x9gknd 4329 3 recurrent recurrent JJ cord-010119-t1x9gknd 4329 4 episodes episode NNS cord-010119-t1x9gknd 4329 5 required require VBD cord-010119-t1x9gknd 4329 6 more more JJR cord-010119-t1x9gknd 4329 7 procedures procedure NNS cord-010119-t1x9gknd 4329 8 compared compare VBN cord-010119-t1x9gknd 4329 9 to to IN cord-010119-t1x9gknd 4329 10 initial initial JJ cord-010119-t1x9gknd 4329 11 presentation presentation NN cord-010119-t1x9gknd 4329 12 ( ( -LRB- cord-010119-t1x9gknd 4329 13 Table table NN cord-010119-t1x9gknd 4329 14 1 1 CD cord-010119-t1x9gknd 4329 15 ) ) -RRB- cord-010119-t1x9gknd 4329 16 . . . cord-010119-t1x9gknd 4330 1 Conclusion conclusion NN cord-010119-t1x9gknd 4330 2 : : : cord-010119-t1x9gknd 4331 1 Recurrent recurrent JJ cord-010119-t1x9gknd 4331 2 / / SYM cord-010119-t1x9gknd 4331 3 relapsed relapse VBD cord-010119-t1x9gknd 4331 4 TTP TTP NNP cord-010119-t1x9gknd 4331 5 demonstrate demonstrate VBP cord-010119-t1x9gknd 4331 6 lower low JJR cord-010119-t1x9gknd 4331 7 A A NNP cord-010119-t1x9gknd 4331 8 - - HYPH cord-010119-t1x9gknd 4331 9 IPC IPC NNP cord-010119-t1x9gknd 4331 10 at at IN cord-010119-t1x9gknd 4331 11 presentation presentation NN cord-010119-t1x9gknd 4331 12 and and CC cord-010119-t1x9gknd 4331 13 a a DT cord-010119-t1x9gknd 4331 14 delayed delay VBN cord-010119-t1x9gknd 4331 15 and and CC cord-010119-t1x9gknd 4331 16 increased increase VBN cord-010119-t1x9gknd 4331 17 A A NNP cord-010119-t1x9gknd 4331 18 - - HYPH cord-010119-t1x9gknd 4331 19 IPC IPC NNP cord-010119-t1x9gknd 4331 20 peak peak NN cord-010119-t1x9gknd 4331 21 value value NN cord-010119-t1x9gknd 4331 22 in in IN cord-010119-t1x9gknd 4331 23 response response NN cord-010119-t1x9gknd 4331 24 to to IN cord-010119-t1x9gknd 4331 25 TPE TPE NNP cord-010119-t1x9gknd 4331 26 compared compare VBN cord-010119-t1x9gknd 4331 27 to to IN cord-010119-t1x9gknd 4331 28 initial initial JJ cord-010119-t1x9gknd 4331 29 presentation presentation NN cord-010119-t1x9gknd 4331 30 . . . cord-010119-t1x9gknd 4332 1 A a DT cord-010119-t1x9gknd 4332 2 longer long JJR cord-010119-t1x9gknd 4332 3 treatment treatment NN cord-010119-t1x9gknd 4332 4 course course NN cord-010119-t1x9gknd 4332 5 was be VBD cord-010119-t1x9gknd 4332 6 observed observe VBN cord-010119-t1x9gknd 4332 7 in in IN cord-010119-t1x9gknd 4332 8 recurrent recurrent JJ cord-010119-t1x9gknd 4332 9 patients patient NNS cord-010119-t1x9gknd 4332 10 . . . cord-010119-t1x9gknd 4333 1 Future future JJ cord-010119-t1x9gknd 4333 2 studies study NNS cord-010119-t1x9gknd 4333 3 of of IN cord-010119-t1x9gknd 4333 4 more more RBR cord-010119-t1x9gknd 4333 5 relapsed relapse VBN cord-010119-t1x9gknd 4333 6 TTP TTP NNP cord-010119-t1x9gknd 4333 7 patients patient NNS cord-010119-t1x9gknd 4333 8 are be VBP cord-010119-t1x9gknd 4333 9 needed need VBN cord-010119-t1x9gknd 4333 10 . . . cord-010119-t1x9gknd 4334 1 Donors donor NNS cord-010119-t1x9gknd 4334 2 Undergoing undergo VBG cord-010119-t1x9gknd 4334 3 Frequent Frequent NNP cord-010119-t1x9gknd 4334 4 Plateletpheresis Plateletpheresis NNP cord-010119-t1x9gknd 4334 5 and and CC cord-010119-t1x9gknd 4334 6 Its -PRON- PRP$ cord-010119-t1x9gknd 4334 7 Effect effect NN cord-010119-t1x9gknd 4334 8 on on IN cord-010119-t1x9gknd 4334 9 the the DT cord-010119-t1x9gknd 4334 10 Hematological Hematological NNP cord-010119-t1x9gknd 4334 11 Parameters Parameters NNP cord-010119-t1x9gknd 4334 12 Sweta Sweta NNP cord-010119-t1x9gknd 4334 13 Nayak Nayak NNP cord-010119-t1x9gknd 4335 1 * * NFP cord-010119-t1x9gknd 4335 2 , , , cord-010119-t1x9gknd 4335 3 Poonam Poonam NNP cord-010119-t1x9gknd 4335 4 Coshic Coshic NNP cord-010119-t1x9gknd 4335 5 and and CC cord-010119-t1x9gknd 4335 6 R.M R.M NNP cord-010119-t1x9gknd 4335 7 Pandey Pandey NNP cord-010119-t1x9gknd 4335 8 . . . cord-010119-t1x9gknd 4336 1 All all DT cord-010119-t1x9gknd 4336 2 India India NNP cord-010119-t1x9gknd 4336 3 Institute Institute NNP cord-010119-t1x9gknd 4336 4 of of IN cord-010119-t1x9gknd 4336 5 Medical Medical NNP cord-010119-t1x9gknd 4336 6 Sciences Sciences NNPS cord-010119-t1x9gknd 4336 7 Background Background NNP cord-010119-t1x9gknd 4336 8 / / SYM cord-010119-t1x9gknd 4336 9 Case Case NNP cord-010119-t1x9gknd 4336 10 Studies Studies NNPS cord-010119-t1x9gknd 4336 11 : : : cord-010119-t1x9gknd 4336 12 Frequent frequent JJ cord-010119-t1x9gknd 4336 13 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4336 14 donors donor NNS cord-010119-t1x9gknd 4336 15 are be VBP cord-010119-t1x9gknd 4336 16 assets asset NNS cord-010119-t1x9gknd 4336 17 for for IN cord-010119-t1x9gknd 4336 18 the the DT cord-010119-t1x9gknd 4336 19 blood blood NN cord-010119-t1x9gknd 4336 20 banks bank NNS cord-010119-t1x9gknd 4336 21 . . . cord-010119-t1x9gknd 4337 1 The the DT cord-010119-t1x9gknd 4337 2 well well RB cord-010119-t1x9gknd 4337 3 - - HYPH cord-010119-t1x9gknd 4337 4 being being NN cord-010119-t1x9gknd 4337 5 of of IN cord-010119-t1x9gknd 4337 6 these these DT cord-010119-t1x9gknd 4337 7 donors donor NNS cord-010119-t1x9gknd 4337 8 has have VBZ cord-010119-t1x9gknd 4337 9 been be VBN cord-010119-t1x9gknd 4337 10 a a DT cord-010119-t1x9gknd 4337 11 matter matter NN cord-010119-t1x9gknd 4337 12 of of IN cord-010119-t1x9gknd 4337 13 concern concern NN cord-010119-t1x9gknd 4337 14 . . . cord-010119-t1x9gknd 4338 1 In in IN cord-010119-t1x9gknd 4338 2 our -PRON- PRP$ cord-010119-t1x9gknd 4338 3 study study NN cord-010119-t1x9gknd 4338 4 we -PRON- PRP cord-010119-t1x9gknd 4338 5 intend intend VBP cord-010119-t1x9gknd 4338 6 to to TO cord-010119-t1x9gknd 4338 7 analyze analyze VB cord-010119-t1x9gknd 4338 8 the the DT cord-010119-t1x9gknd 4338 9 effect effect NN cord-010119-t1x9gknd 4338 10 of of IN cord-010119-t1x9gknd 4338 11 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4338 12 on on IN cord-010119-t1x9gknd 4338 13 the the DT cord-010119-t1x9gknd 4338 14 hematological hematological JJ cord-010119-t1x9gknd 4338 15 parameters parameter NNS cord-010119-t1x9gknd 4338 16 of of IN cord-010119-t1x9gknd 4338 17 these these DT cord-010119-t1x9gknd 4338 18 donors donor NNS cord-010119-t1x9gknd 4338 19 assessed assess VBN cord-010119-t1x9gknd 4338 20 prior prior RB cord-010119-t1x9gknd 4338 21 to to IN cord-010119-t1x9gknd 4338 22 each each DT cord-010119-t1x9gknd 4338 23 subsequent subsequent JJ cord-010119-t1x9gknd 4338 24 procedure procedure NN cord-010119-t1x9gknd 4338 25 . . . cord-010119-t1x9gknd 4339 1 We -PRON- PRP cord-010119-t1x9gknd 4339 2 also also RB cord-010119-t1x9gknd 4339 3 try try VBP cord-010119-t1x9gknd 4339 4 to to TO cord-010119-t1x9gknd 4339 5 compare compare VB cord-010119-t1x9gknd 4339 6 the the DT cord-010119-t1x9gknd 4339 7 effect effect NN cord-010119-t1x9gknd 4339 8 3 3 CD cord-010119-t1x9gknd 4339 9 cell cell NN cord-010119-t1x9gknd 4339 10 separators separator NNS cord-010119-t1x9gknd 4339 11 used use VBN cord-010119-t1x9gknd 4339 12 for for IN cord-010119-t1x9gknd 4339 13 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4339 14 on on IN cord-010119-t1x9gknd 4339 15 the the DT cord-010119-t1x9gknd 4339 16 post post NN cord-010119-t1x9gknd 4339 17 donation donation NN cord-010119-t1x9gknd 4339 18 hematological hematological JJ cord-010119-t1x9gknd 4339 19 parameters parameter NNS cord-010119-t1x9gknd 4339 20 . . . cord-010119-t1x9gknd 4340 1 Study Study NNP cord-010119-t1x9gknd 4340 2 Design Design NNP cord-010119-t1x9gknd 4340 3 / / SYM cord-010119-t1x9gknd 4340 4 Method method NN cord-010119-t1x9gknd 4340 5 : : : cord-010119-t1x9gknd 4341 1 The the DT cord-010119-t1x9gknd 4341 2 study study NN cord-010119-t1x9gknd 4341 3 was be VBD cord-010119-t1x9gknd 4341 4 conducted conduct VBN cord-010119-t1x9gknd 4341 5 during during IN cord-010119-t1x9gknd 4341 6 February February NNP cord-010119-t1x9gknd 4341 7 2016 2016 CD cord-010119-t1x9gknd 4341 8 to to IN cord-010119-t1x9gknd 4341 9 March March NNP cord-010119-t1x9gknd 4341 10 2017 2017 CD cord-010119-t1x9gknd 4341 11 on on IN cord-010119-t1x9gknd 4341 12 all all PDT cord-010119-t1x9gknd 4341 13 the the DT cord-010119-t1x9gknd 4341 14 repeat repeat NN cord-010119-t1x9gknd 4341 15 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4341 16 donors donor NNS cord-010119-t1x9gknd 4341 17 coming come VBG cord-010119-t1x9gknd 4341 18 to to IN cord-010119-t1x9gknd 4341 19 the the DT cord-010119-t1x9gknd 4341 20 Department Department NNP cord-010119-t1x9gknd 4341 21 of of IN cord-010119-t1x9gknd 4341 22 Transfusion Transfusion NNP cord-010119-t1x9gknd 4341 23 Medicine Medicine NNP cord-010119-t1x9gknd 4341 24 for for IN cord-010119-t1x9gknd 4341 25 the the DT cord-010119-t1x9gknd 4341 26 2 2 CD cord-010119-t1x9gknd 4341 27 nd nd NNP cord-010119-t1x9gknd 4341 28 time time NN cord-010119-t1x9gknd 4341 29 within within IN cord-010119-t1x9gknd 4341 30 a a DT cord-010119-t1x9gknd 4341 31 month month NN cord-010119-t1x9gknd 4341 32 of of IN cord-010119-t1x9gknd 4341 33 the the DT cord-010119-t1x9gknd 4341 34 first first JJ cord-010119-t1x9gknd 4341 35 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4341 36 . . . cord-010119-t1x9gknd 4342 1 The the DT cord-010119-t1x9gknd 4342 2 values value NNS cord-010119-t1x9gknd 4342 3 of of IN cord-010119-t1x9gknd 4342 4 the the DT cord-010119-t1x9gknd 4342 5 hematological hematological JJ cord-010119-t1x9gknd 4342 6 parameters parameter NNS cord-010119-t1x9gknd 4342 7 including include VBG cord-010119-t1x9gknd 4342 8 red red JJ cord-010119-t1x9gknd 4342 9 cell cell NN cord-010119-t1x9gknd 4342 10 and and CC cord-010119-t1x9gknd 4342 11 platelet platelet NN cord-010119-t1x9gknd 4342 12 indices index NNS cord-010119-t1x9gknd 4342 13 tested test VBN cord-010119-t1x9gknd 4342 14 prior prior RB cord-010119-t1x9gknd 4342 15 to to IN cord-010119-t1x9gknd 4342 16 each each DT cord-010119-t1x9gknd 4342 17 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4342 18 were be VBD cord-010119-t1x9gknd 4342 19 entered enter VBN cord-010119-t1x9gknd 4342 20 into into IN cord-010119-t1x9gknd 4342 21 the the DT cord-010119-t1x9gknd 4342 22 excel excel NNP cord-010119-t1x9gknd 4342 23 sheet sheet NN cord-010119-t1x9gknd 4342 24 and and CC cord-010119-t1x9gknd 4342 25 gap gap NN cord-010119-t1x9gknd 4342 26 between between IN cord-010119-t1x9gknd 4342 27 each each DT cord-010119-t1x9gknd 4342 28 donations donation NNS cord-010119-t1x9gknd 4342 29 were be VBD cord-010119-t1x9gknd 4342 30 calculated calculate VBN cord-010119-t1x9gknd 4342 31 . . . cord-010119-t1x9gknd 4343 1 The the DT cord-010119-t1x9gknd 4343 2 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4343 3 were be VBD cord-010119-t1x9gknd 4343 4 done do VBN cord-010119-t1x9gknd 4343 5 either either CC cord-010119-t1x9gknd 4343 6 on on IN cord-010119-t1x9gknd 4343 7 Hemonetics Hemonetics NNP cord-010119-t1x9gknd 4343 8 MCS1 MCS1 NNP cord-010119-t1x9gknd 4343 9 separator separator NN cord-010119-t1x9gknd 4343 10 ( ( -LRB- cord-010119-t1x9gknd 4343 11 Hemonetics Hemonetics NNP cord-010119-t1x9gknd 4343 12 Corporation Corporation NNP cord-010119-t1x9gknd 4343 13 , , , cord-010119-t1x9gknd 4343 14 Braintree Braintree NNP cord-010119-t1x9gknd 4343 15 , , , cord-010119-t1x9gknd 4343 16 Massachusetts Massachusetts NNP cord-010119-t1x9gknd 4343 17 , , , cord-010119-t1x9gknd 4343 18 USA USA NNP cord-010119-t1x9gknd 4343 19 ) ) -RRB- cord-010119-t1x9gknd 4343 20 , , , cord-010119-t1x9gknd 4343 21 Fresinius Fresinius NNP cord-010119-t1x9gknd 4343 22 separator separator NN cord-010119-t1x9gknd 4343 23 ( ( -LRB- cord-010119-t1x9gknd 4343 24 COM.TEC COM.TEC NNP cord-010119-t1x9gknd 4343 25 ) ) -RRB- cord-010119-t1x9gknd 4343 26 , , , cord-010119-t1x9gknd 4343 27 DN DN NNP cord-010119-t1x9gknd 4343 28 ( ( -LRB- cord-010119-t1x9gknd 4343 29 Fresinius Fresinius NNP cord-010119-t1x9gknd 4343 30 HemoCare HemoCare NNP cord-010119-t1x9gknd 4343 31 GmbH GmbH NNP cord-010119-t1x9gknd 4343 32 , , , cord-010119-t1x9gknd 4343 33 Bad Bad NNP cord-010119-t1x9gknd 4343 34 Homburg Homburg NNP cord-010119-t1x9gknd 4343 35 v.d v.d NNP cord-010119-t1x9gknd 4343 36 . . NNP cord-010119-t1x9gknd 4343 37 H H NNP cord-010119-t1x9gknd 4343 38 , , , cord-010119-t1x9gknd 4343 39 Germany Germany NNP cord-010119-t1x9gknd 4343 40 ) ) -RRB- cord-010119-t1x9gknd 4343 41 and and CC cord-010119-t1x9gknd 4343 42 Gambro Gambro NNP cord-010119-t1x9gknd 4343 43 Trima Trima NNP cord-010119-t1x9gknd 4343 44 Accel Accel NNP cord-010119-t1x9gknd 4343 45 , , , cord-010119-t1x9gknd 4343 46 software software NN cord-010119-t1x9gknd 4343 47 version version NN cord-010119-t1x9gknd 4343 48 5.0 5.0 CD cord-010119-t1x9gknd 4343 49 after after IN cord-010119-t1x9gknd 4343 50 taking take VBG cord-010119-t1x9gknd 4343 51 consent consent NN cord-010119-t1x9gknd 4343 52 from from IN cord-010119-t1x9gknd 4343 53 the the DT cord-010119-t1x9gknd 4343 54 donors donor NNS cord-010119-t1x9gknd 4343 55 . . . cord-010119-t1x9gknd 4344 1 The the DT cord-010119-t1x9gknd 4344 2 target target NN cord-010119-t1x9gknd 4344 3 collection collection NN cord-010119-t1x9gknd 4344 4 of of IN cord-010119-t1x9gknd 4344 5 each each DT cord-010119-t1x9gknd 4344 6 procedure procedure NN cord-010119-t1x9gknd 4344 7 was be VBD cord-010119-t1x9gknd 4344 8 a a DT cord-010119-t1x9gknd 4344 9 dose dose NN cord-010119-t1x9gknd 4344 10 of of IN cord-010119-t1x9gknd 4344 11 3 3 CD cord-010119-t1x9gknd 4344 12 x x SYM cord-010119-t1x9gknd 4344 13 10 10 CD cord-010119-t1x9gknd 4344 14 11 11 CD cord-010119-t1x9gknd 4344 15 platelets platelet NNS cord-010119-t1x9gknd 4344 16 in in IN cord-010119-t1x9gknd 4344 17 200 200 CD cord-010119-t1x9gknd 4344 18 - - SYM cord-010119-t1x9gknd 4344 19 250 250 CD cord-010119-t1x9gknd 4344 20 ml ml NNS cord-010119-t1x9gknd 4344 21 of of IN cord-010119-t1x9gknd 4344 22 plasma plasma NN cord-010119-t1x9gknd 4344 23 . . . cord-010119-t1x9gknd 4345 1 To to TO cord-010119-t1x9gknd 4345 2 compare compare VB cord-010119-t1x9gknd 4345 3 the the DT cord-010119-t1x9gknd 4345 4 effect effect NN cord-010119-t1x9gknd 4345 5 of of IN cord-010119-t1x9gknd 4345 6 the the DT cord-010119-t1x9gknd 4345 7 cell cell NN cord-010119-t1x9gknd 4345 8 separators separator NNS cord-010119-t1x9gknd 4345 9 on on IN cord-010119-t1x9gknd 4345 10 the the DT cord-010119-t1x9gknd 4345 11 hematological hematological JJ cord-010119-t1x9gknd 4345 12 parameters parameter NNS cord-010119-t1x9gknd 4345 13 due due JJ cord-010119-t1x9gknd 4345 14 to to IN cord-010119-t1x9gknd 4345 15 the the DT cord-010119-t1x9gknd 4345 16 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4345 17 , , , cord-010119-t1x9gknd 4345 18 parameters parameter VBZ cord-010119-t1x9gknd 4345 19 at at IN cord-010119-t1x9gknd 4345 20 2 2 CD cord-010119-t1x9gknd 4345 21 consecutive consecutive JJ cord-010119-t1x9gknd 4345 22 donations donation NNS cord-010119-t1x9gknd 4345 23 within within IN cord-010119-t1x9gknd 4345 24 7 7 CD cord-010119-t1x9gknd 4345 25 days day NNS cord-010119-t1x9gknd 4345 26 were be VBD cord-010119-t1x9gknd 4345 27 considered consider VBN cord-010119-t1x9gknd 4345 28 . . . cord-010119-t1x9gknd 4346 1 Data datum NNS cord-010119-t1x9gknd 4346 2 was be VBD cord-010119-t1x9gknd 4346 3 analyzed analyze VBN cord-010119-t1x9gknd 4346 4 by by IN cord-010119-t1x9gknd 4346 5 Stata Stata NNP cord-010119-t1x9gknd 4346 6 14 14 CD cord-010119-t1x9gknd 4346 7 . . . cord-010119-t1x9gknd 4347 1 Within within IN cord-010119-t1x9gknd 4347 2 change change NN cord-010119-t1x9gknd 4347 3 in in IN cord-010119-t1x9gknd 4347 4 the the DT cord-010119-t1x9gknd 4347 5 continuous continuous JJ cord-010119-t1x9gknd 4347 6 variables variable NNS cord-010119-t1x9gknd 4347 7 were be VBD cord-010119-t1x9gknd 4347 8 assessed assess VBN cord-010119-t1x9gknd 4347 9 by by IN cord-010119-t1x9gknd 4347 10 paired pair VBN cord-010119-t1x9gknd 4347 11 t t NN cord-010119-t1x9gknd 4347 12 - - HYPH cord-010119-t1x9gknd 4347 13 test test NN cord-010119-t1x9gknd 4347 14 and and CC cord-010119-t1x9gknd 4347 15 between between IN cord-010119-t1x9gknd 4347 16 two two CD cord-010119-t1x9gknd 4347 17 groups group NNS cord-010119-t1x9gknd 4347 18 comparison comparison NN cord-010119-t1x9gknd 4347 19 was be VBD cord-010119-t1x9gknd 4347 20 done do VBN cord-010119-t1x9gknd 4347 21 by by IN cord-010119-t1x9gknd 4347 22 independent independent JJ cord-010119-t1x9gknd 4347 23 t t NN cord-010119-t1x9gknd 4347 24 - - HYPH cord-010119-t1x9gknd 4347 25 test test NN cord-010119-t1x9gknd 4347 26 or or CC cord-010119-t1x9gknd 4347 27 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 4347 28 Rank Rank NNP cord-010119-t1x9gknd 4347 29 Sum Sum NNP cord-010119-t1x9gknd 4347 30 test test NN cord-010119-t1x9gknd 4347 31 . . . cord-010119-t1x9gknd 4348 1 The the DT cord-010119-t1x9gknd 4348 2 comparison comparison NN cord-010119-t1x9gknd 4348 3 among among IN cord-010119-t1x9gknd 4348 4 the the DT cord-010119-t1x9gknd 4348 5 cell cell NN cord-010119-t1x9gknd 4348 6 separators separator NNS cord-010119-t1x9gknd 4348 7 was be VBD cord-010119-t1x9gknd 4348 8 done do VBN cord-010119-t1x9gknd 4348 9 by by IN cord-010119-t1x9gknd 4348 10 Kruskal Kruskal NNP cord-010119-t1x9gknd 4348 11 - - HYPH cord-010119-t1x9gknd 4348 12 Wallis Wallis NNP cord-010119-t1x9gknd 4348 13 test test NN cord-010119-t1x9gknd 4348 14 or or CC cord-010119-t1x9gknd 4348 15 one one CD cord-010119-t1x9gknd 4348 16 way way NN cord-010119-t1x9gknd 4348 17 ANOVA ANOVA NNP cord-010119-t1x9gknd 4348 18 . . . cord-010119-t1x9gknd 4349 1 Results result NNS cord-010119-t1x9gknd 4350 1 /Finding /finde VBG cord-010119-t1x9gknd 4350 2 : : : cord-010119-t1x9gknd 4350 3 Of of IN cord-010119-t1x9gknd 4350 4 the the DT cord-010119-t1x9gknd 4350 5 98 98 CD cord-010119-t1x9gknd 4350 6 donors donor NNS cord-010119-t1x9gknd 4350 7 , , , cord-010119-t1x9gknd 4350 8 35 35 CD cord-010119-t1x9gknd 4350 9 repeated repeat VBD cord-010119-t1x9gknd 4350 10 the the DT cord-010119-t1x9gknd 4350 11 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4350 12 within within IN cord-010119-t1x9gknd 4350 13 a a DT cord-010119-t1x9gknd 4350 14 week week NN cord-010119-t1x9gknd 4350 15 ( ( -LRB- cord-010119-t1x9gknd 4350 16 group group NN cord-010119-t1x9gknd 4350 17 I I NNP cord-010119-t1x9gknd 4350 18 ) ) -RRB- cord-010119-t1x9gknd 4350 19 and and CC cord-010119-t1x9gknd 4350 20 63 63 CD cord-010119-t1x9gknd 4350 21 underwent undergo VBD cord-010119-t1x9gknd 4350 22 2 2 CD cord-010119-t1x9gknd 4350 23 nd nd NNP cord-010119-t1x9gknd 4350 24 plateletpheresis plateletpheresis NNP cord-010119-t1x9gknd 4350 25 within within IN cord-010119-t1x9gknd 4350 26 8 8 CD cord-010119-t1x9gknd 4350 27 - - SYM cord-010119-t1x9gknd 4350 28 30 30 CD cord-010119-t1x9gknd 4350 29 days day NNS cord-010119-t1x9gknd 4350 30 ( ( -LRB- cord-010119-t1x9gknd 4350 31 group group NN cord-010119-t1x9gknd 4350 32 II II NNP cord-010119-t1x9gknd 4350 33 ) ) -RRB- cord-010119-t1x9gknd 4350 34 . . . cord-010119-t1x9gknd 4351 1 No no DT cord-010119-t1x9gknd 4351 2 significant significant JJ cord-010119-t1x9gknd 4351 3 alteration alteration NN cord-010119-t1x9gknd 4351 4 was be VBD cord-010119-t1x9gknd 4351 5 found find VBN cord-010119-t1x9gknd 4351 6 in in IN cord-010119-t1x9gknd 4351 7 the the DT cord-010119-t1x9gknd 4351 8 red red JJ cord-010119-t1x9gknd 4351 9 cell cell NN cord-010119-t1x9gknd 4351 10 or or CC cord-010119-t1x9gknd 4351 11 the the DT cord-010119-t1x9gknd 4351 12 platelet platelet NN cord-010119-t1x9gknd 4351 13 indices index NNS cord-010119-t1x9gknd 4351 14 within within IN cord-010119-t1x9gknd 4351 15 either either CC cord-010119-t1x9gknd 4351 16 group group NN cord-010119-t1x9gknd 4351 17 but but CC cord-010119-t1x9gknd 4351 18 a a DT cord-010119-t1x9gknd 4351 19 significant significant JJ cord-010119-t1x9gknd 4351 20 difference difference NN cord-010119-t1x9gknd 4351 21 in in IN cord-010119-t1x9gknd 4351 22 the the DT cord-010119-t1x9gknd 4351 23 variation variation NN cord-010119-t1x9gknd 4351 24 of of IN cord-010119-t1x9gknd 4351 25 platelet platelet NN cord-010119-t1x9gknd 4351 26 counts count NNS cord-010119-t1x9gknd 4351 27 of of IN cord-010119-t1x9gknd 4351 28 the the DT cord-010119-t1x9gknd 4351 29 2 2 CD cord-010119-t1x9gknd 4351 30 groups group NNS cord-010119-t1x9gknd 4351 31 ( ( -LRB- cord-010119-t1x9gknd 4351 32 p50.025 p50.025 NN cord-010119-t1x9gknd 4351 33 ) ) -RRB- cord-010119-t1x9gknd 4351 34 . . . cord-010119-t1x9gknd 4352 1 Though though IN cord-010119-t1x9gknd 4352 2 above above IN cord-010119-t1x9gknd 4352 3 the the DT cord-010119-t1x9gknd 4352 4 eligibility eligibility NN cord-010119-t1x9gknd 4352 5 cutoff cutoff NN cord-010119-t1x9gknd 4352 6 of of IN cord-010119-t1x9gknd 4352 7 1.5 1.5 CD cord-010119-t1x9gknd 4352 8 lakhs lakh NNS cord-010119-t1x9gknd 4352 9 / / SYM cord-010119-t1x9gknd 4352 10 ml ml NN cord-010119-t1x9gknd 4352 11 , , , cord-010119-t1x9gknd 4352 12 platelet platelet NN cord-010119-t1x9gknd 4352 13 counts count NNS cord-010119-t1x9gknd 4352 14 were be VBD cord-010119-t1x9gknd 4352 15 lower low JJR cord-010119-t1x9gknd 4352 16 than than IN cord-010119-t1x9gknd 4352 17 baseline baseline NN cord-010119-t1x9gknd 4352 18 in in IN cord-010119-t1x9gknd 4352 19 group group NN cord-010119-t1x9gknd 4352 20 I -PRON- PRP cord-010119-t1x9gknd 4352 21 donors donor NNS cord-010119-t1x9gknd 4352 22 whereas whereas IN cord-010119-t1x9gknd 4352 23 it -PRON- PRP cord-010119-t1x9gknd 4352 24 was be VBD cord-010119-t1x9gknd 4352 25 higher high JJR cord-010119-t1x9gknd 4352 26 at at IN cord-010119-t1x9gknd 4352 27 2 2 CD cord-010119-t1x9gknd 4352 28 nd nd NNP cord-010119-t1x9gknd 4352 29 plateletpheresis plateletpheresis NNP cord-010119-t1x9gknd 4352 30 in in IN cord-010119-t1x9gknd 4352 31 group group NN cord-010119-t1x9gknd 4352 32 II ii CD cord-010119-t1x9gknd 4352 33 donors donor NNS cord-010119-t1x9gknd 4352 34 . . . cord-010119-t1x9gknd 4353 1 There there EX cord-010119-t1x9gknd 4353 2 were be VBD cord-010119-t1x9gknd 4353 3 49 49 CD cord-010119-t1x9gknd 4353 4 donors donor NNS cord-010119-t1x9gknd 4353 5 who who WP cord-010119-t1x9gknd 4353 6 presented present VBD cord-010119-t1x9gknd 4353 7 to to IN cord-010119-t1x9gknd 4353 8 us -PRON- PRP cord-010119-t1x9gknd 4353 9 for for IN cord-010119-t1x9gknd 4353 10 the the DT cord-010119-t1x9gknd 4353 11 3 3 CD cord-010119-t1x9gknd 4353 12 rd rd NNP cord-010119-t1x9gknd 4353 13 time time NN cord-010119-t1x9gknd 4353 14 for for IN cord-010119-t1x9gknd 4353 15 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4353 16 with with IN cord-010119-t1x9gknd 4353 17 a a DT cord-010119-t1x9gknd 4353 18 mean mean JJ cord-010119-t1x9gknd 4353 19 gap gap NN cord-010119-t1x9gknd 4353 20 between between IN cord-010119-t1x9gknd 4353 21 1 1 CD cord-010119-t1x9gknd 4353 22 st st NNP cord-010119-t1x9gknd 4353 23 and and CC cord-010119-t1x9gknd 4353 24 3 3 CD cord-010119-t1x9gknd 4353 25 rd rd NNP cord-010119-t1x9gknd 4353 26 plateletpheresis plateletpheresis NNP cord-010119-t1x9gknd 4353 27 being be VBG cord-010119-t1x9gknd 4353 28 46 46 CD cord-010119-t1x9gknd 4353 29 days day NNS cord-010119-t1x9gknd 4353 30 . . . cord-010119-t1x9gknd 4354 1 No no DT cord-010119-t1x9gknd 4354 2 significant significant JJ cord-010119-t1x9gknd 4354 3 difference difference NN cord-010119-t1x9gknd 4354 4 in in IN cord-010119-t1x9gknd 4354 5 the the DT cord-010119-t1x9gknd 4354 6 parameters parameter NNS cord-010119-t1x9gknd 4354 7 assessed assess VBN cord-010119-t1x9gknd 4354 8 prior prior RB cord-010119-t1x9gknd 4354 9 to to IN cord-010119-t1x9gknd 4354 10 any any DT cord-010119-t1x9gknd 4354 11 of of IN cord-010119-t1x9gknd 4354 12 the the DT cord-010119-t1x9gknd 4354 13 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4354 14 was be VBD cord-010119-t1x9gknd 4354 15 found find VBN cord-010119-t1x9gknd 4354 16 except except IN cord-010119-t1x9gknd 4354 17 the the DT cord-010119-t1x9gknd 4354 18 platelet platelet NN cord-010119-t1x9gknd 4354 19 distribution distribution NN cord-010119-t1x9gknd 4354 20 width width NN cord-010119-t1x9gknd 4354 21 ( ( -LRB- cord-010119-t1x9gknd 4354 22 p50.000 p50.000 NNP cord-010119-t1x9gknd 4354 23 ) ) -RRB- cord-010119-t1x9gknd 4354 24 . . . cord-010119-t1x9gknd 4355 1 Plateletpheresis Plateletpheresis NNP cord-010119-t1x9gknd 4355 2 through through IN cord-010119-t1x9gknd 4355 3 all all PDT cord-010119-t1x9gknd 4355 4 the the DT cord-010119-t1x9gknd 4355 5 3 3 CD cord-010119-t1x9gknd 4355 6 cell cell NN cord-010119-t1x9gknd 4355 7 separators separator NNS cord-010119-t1x9gknd 4355 8 had have VBD cord-010119-t1x9gknd 4355 9 similar similar JJ cord-010119-t1x9gknd 4355 10 effects effect NNS cord-010119-t1x9gknd 4355 11 on on IN cord-010119-t1x9gknd 4355 12 the the DT cord-010119-t1x9gknd 4355 13 hematological hematological JJ cord-010119-t1x9gknd 4355 14 parameters parameter NNS cord-010119-t1x9gknd 4355 15 . . . cord-010119-t1x9gknd 4356 1 Conclusion conclusion NN cord-010119-t1x9gknd 4356 2 : : : cord-010119-t1x9gknd 4356 3 There there EX cord-010119-t1x9gknd 4356 4 was be VBD cord-010119-t1x9gknd 4356 5 no no DT cord-010119-t1x9gknd 4356 6 significant significant JJ cord-010119-t1x9gknd 4356 7 change change NN cord-010119-t1x9gknd 4356 8 in in IN cord-010119-t1x9gknd 4356 9 the the DT cord-010119-t1x9gknd 4356 10 hematological hematological JJ cord-010119-t1x9gknd 4356 11 parameters parameter NNS cord-010119-t1x9gknd 4356 12 in in IN cord-010119-t1x9gknd 4356 13 the the DT cord-010119-t1x9gknd 4356 14 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4356 15 donors donor NNS cord-010119-t1x9gknd 4356 16 who who WP cord-010119-t1x9gknd 4356 17 underwent undergo VBD cord-010119-t1x9gknd 4356 18 frequent frequent JJ cord-010119-t1x9gknd 4356 19 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 4356 20 . . . cord-010119-t1x9gknd 4357 1 Post post JJ cord-010119-t1x9gknd 4357 2 donation donation NN cord-010119-t1x9gknd 4357 3 follow follow NN cord-010119-t1x9gknd 4357 4 - - HYPH cord-010119-t1x9gknd 4357 5 up up RP cord-010119-t1x9gknd 4357 6 hematological hematological JJ cord-010119-t1x9gknd 4357 7 parameters parameter NNS cord-010119-t1x9gknd 4357 8 were be VBD cord-010119-t1x9gknd 4357 9 not not RB cord-010119-t1x9gknd 4357 10 affected affect VBN cord-010119-t1x9gknd 4357 11 by by IN cord-010119-t1x9gknd 4357 12 the the DT cord-010119-t1x9gknd 4357 13 cell cell NN cord-010119-t1x9gknd 4357 14 separators separator NNS cord-010119-t1x9gknd 4357 15 used use VBN cord-010119-t1x9gknd 4357 16 for for IN cord-010119-t1x9gknd 4357 17 plateletpheresis plateletpheresis NNP cord-010119-t1x9gknd 4357 18 . . . cord-010119-t1x9gknd 4358 1 Efficacy efficacy NN cord-010119-t1x9gknd 4358 2 of of IN cord-010119-t1x9gknd 4358 3 Therapeutic Therapeutic NNP cord-010119-t1x9gknd 4358 4 Plasma Plasma NNP cord-010119-t1x9gknd 4358 5 Exchange Exchange NNP cord-010119-t1x9gknd 4358 6 on on IN cord-010119-t1x9gknd 4358 7 Angiotensin Angiotensin NNP cord-010119-t1x9gknd 4358 8 II II NNP cord-010119-t1x9gknd 4358 9 Type Type NNP cord-010119-t1x9gknd 4358 10 1 1 CD cord-010119-t1x9gknd 4358 11 Receptor Receptor NNP cord-010119-t1x9gknd 4358 12 Antibodies Antibodies NNPS cord-010119-t1x9gknd 4358 13 in in IN cord-010119-t1x9gknd 4358 14 Two two CD cord-010119-t1x9gknd 4358 15 Kidney kidney NN cord-010119-t1x9gknd 4358 16 Transplant Transplant NNP cord-010119-t1x9gknd 4358 17 Recipients Recipients NNP cord-010119-t1x9gknd 4358 18 Chisa Chisa NNP cord-010119-t1x9gknd 4358 19 Yamada Yamada NNP cord-010119-t1x9gknd 4359 1 * * NFP cord-010119-t1x9gknd 4359 2 , , , cord-010119-t1x9gknd 4359 3 Silas Silas NNP cord-010119-t1x9gknd 4359 4 P. P. NNP cord-010119-t1x9gknd 4359 5 Norman Norman NNP cord-010119-t1x9gknd 4359 6 , , , cord-010119-t1x9gknd 4359 7 Milagros Milagros NNP cord-010119-t1x9gknd 4359 8 Samaniego Samaniego NNP cord-010119-t1x9gknd 4359 9 and and CC cord-010119-t1x9gknd 4359 10 Laura Laura NNP cord-010119-t1x9gknd 4359 11 Cooling Cooling NNP cord-010119-t1x9gknd 4359 12 . . . cord-010119-t1x9gknd 4360 1 Background Background NNP cord-010119-t1x9gknd 4360 2 / / SYM cord-010119-t1x9gknd 4360 3 Case Case NNP cord-010119-t1x9gknd 4360 4 Studies Studies NNPS cord-010119-t1x9gknd 4360 5 : : : cord-010119-t1x9gknd 4361 1 Some some DT cord-010119-t1x9gknd 4361 2 kidney kidney NN cord-010119-t1x9gknd 4361 3 transplant transplant NN cord-010119-t1x9gknd 4361 4 recipients recipient NNS cord-010119-t1x9gknd 4361 5 develop develop VBP cord-010119-t1x9gknd 4361 6 antibody antibody NN cord-010119-t1x9gknd 4361 7 mediated mediate VBN cord-010119-t1x9gknd 4361 8 rejection rejection NN cord-010119-t1x9gknd 4361 9 ( ( -LRB- cord-010119-t1x9gknd 4361 10 AMR AMR NNP cord-010119-t1x9gknd 4361 11 ) ) -RRB- cord-010119-t1x9gknd 4361 12 without without IN cord-010119-t1x9gknd 4361 13 detected detect VBN cord-010119-t1x9gknd 4361 14 HLA HLA NNP cord-010119-t1x9gknd 4361 15 donor donor NN cord-010119-t1x9gknd 4361 16 specific specific JJ cord-010119-t1x9gknd 4361 17 antibodies antibody NNS cord-010119-t1x9gknd 4361 18 ( ( -LRB- cord-010119-t1x9gknd 4361 19 DSAs dsa NNS cord-010119-t1x9gknd 4361 20 ) ) -RRB- cord-010119-t1x9gknd 4361 21 in in IN cord-010119-t1x9gknd 4361 22 sera sera NNP cord-010119-t1x9gknd 4361 23 . . . cord-010119-t1x9gknd 4362 1 In in IN cord-010119-t1x9gknd 4362 2 recent recent JJ cord-010119-t1x9gknd 4362 3 years year NNS cord-010119-t1x9gknd 4362 4 , , , cord-010119-t1x9gknd 4362 5 angiotensin angiotensin NN cord-010119-t1x9gknd 4362 6 II ii CD cord-010119-t1x9gknd 4362 7 type-1 type-1 NNP cord-010119-t1x9gknd 4362 8 receptor receptor NN cord-010119-t1x9gknd 4362 9 antibody antibody NN cord-010119-t1x9gknd 4362 10 ( ( -LRB- cord-010119-t1x9gknd 4362 11 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4362 12 ) ) -RRB- cord-010119-t1x9gknd 4362 13 has have VBZ cord-010119-t1x9gknd 4362 14 been be VBN cord-010119-t1x9gknd 4362 15 reported report VBN cord-010119-t1x9gknd 4362 16 to to TO cord-010119-t1x9gknd 4362 17 cause cause VB cord-010119-t1x9gknd 4362 18 AMR AMR NNP cord-010119-t1x9gknd 4362 19 , , , cord-010119-t1x9gknd 4362 20 especially especially RB cord-010119-t1x9gknd 4362 21 refractory refractory JJ cord-010119-t1x9gknd 4362 22 AMR AMR NNP cord-010119-t1x9gknd 4362 23 , , , cord-010119-t1x9gknd 4362 24 possibly possibly RB cord-010119-t1x9gknd 4362 25 by by IN cord-010119-t1x9gknd 4362 26 contraction contraction NN cord-010119-t1x9gknd 4362 27 of of IN cord-010119-t1x9gknd 4362 28 renal renal JJ cord-010119-t1x9gknd 4362 29 arteries artery NNS cord-010119-t1x9gknd 4362 30 . . . cord-010119-t1x9gknd 4363 1 At at IN cord-010119-t1x9gknd 4363 2 our -PRON- PRP$ cord-010119-t1x9gknd 4363 3 institution institution NN cord-010119-t1x9gknd 4363 4 , , , cord-010119-t1x9gknd 4363 5 therapeutic therapeutic JJ cord-010119-t1x9gknd 4363 6 plasma plasma NN cord-010119-t1x9gknd 4363 7 exchange exchange NN cord-010119-t1x9gknd 4363 8 ( ( -LRB- cord-010119-t1x9gknd 4363 9 TPE TPE NNP cord-010119-t1x9gknd 4363 10 ) ) -RRB- cord-010119-t1x9gknd 4363 11 followed follow VBN cord-010119-t1x9gknd 4363 12 by by IN cord-010119-t1x9gknd 4363 13 IVIG IVIG NNP cord-010119-t1x9gknd 4363 14 every every DT cord-010119-t1x9gknd 4363 15 other other JJ cord-010119-t1x9gknd 4363 16 day day NN cord-010119-t1x9gknd 4363 17 has have VBZ cord-010119-t1x9gknd 4363 18 been be VBN cord-010119-t1x9gknd 4363 19 applied apply VBN cord-010119-t1x9gknd 4363 20 to to TO cord-010119-t1x9gknd 4363 21 reduce reduce VB cord-010119-t1x9gknd 4363 22 AT1RAbs at1rabs NN cord-010119-t1x9gknd 4363 23 in in IN cord-010119-t1x9gknd 4363 24 kidney kidney NN cord-010119-t1x9gknd 4363 25 transplant transplant NN cord-010119-t1x9gknd 4363 26 recipients recipient NNS cord-010119-t1x9gknd 4363 27 , , , cord-010119-t1x9gknd 4363 28 and and CC cord-010119-t1x9gknd 4363 29 we -PRON- PRP cord-010119-t1x9gknd 4363 30 here here RB cord-010119-t1x9gknd 4363 31 report report VBP cord-010119-t1x9gknd 4363 32 efficacy efficacy NN cord-010119-t1x9gknd 4363 33 of of IN cord-010119-t1x9gknd 4363 34 TPE TPE NNP cord-010119-t1x9gknd 4363 35 treatments treatment NNS cord-010119-t1x9gknd 4363 36 in in IN cord-010119-t1x9gknd 4363 37 two two CD cord-010119-t1x9gknd 4363 38 cases case NNS cord-010119-t1x9gknd 4363 39 . . . cord-010119-t1x9gknd 4364 1 Study Study NNP cord-010119-t1x9gknd 4364 2 Design Design NNP cord-010119-t1x9gknd 4364 3 / / SYM cord-010119-t1x9gknd 4364 4 Methods method NNS cord-010119-t1x9gknd 4364 5 : : : cord-010119-t1x9gknd 4365 1 Two two CD cord-010119-t1x9gknd 4365 2 kidney kidney NN cord-010119-t1x9gknd 4365 3 transplant transplant NN cord-010119-t1x9gknd 4365 4 recipients recipient NNS cord-010119-t1x9gknd 4365 5 who who WP cord-010119-t1x9gknd 4365 6 received receive VBD cord-010119-t1x9gknd 4365 7 TPE TPE NNP cord-010119-t1x9gknd 4365 8 treatment treatment NN cord-010119-t1x9gknd 4365 9 followed follow VBN cord-010119-t1x9gknd 4365 10 by by IN cord-010119-t1x9gknd 4365 11 IVIG IVIG NNP cord-010119-t1x9gknd 4365 12 to to IN cord-010119-t1x9gknd 4365 13 decreased decrease VBD cord-010119-t1x9gknd 4365 14 AT1R at1r CD cord-010119-t1x9gknd 4366 1 Ab Ab NNP cord-010119-t1x9gknd 4366 2 are be VBP cord-010119-t1x9gknd 4366 3 reviewed review VBN cord-010119-t1x9gknd 4366 4 . . . cord-010119-t1x9gknd 4367 1 Results result NNS cord-010119-t1x9gknd 4367 2 / / SYM cord-010119-t1x9gknd 4367 3 Findings finding NNS cord-010119-t1x9gknd 4367 4 : : : cord-010119-t1x9gknd 4367 5 Case case NN cord-010119-t1x9gknd 4367 6 1 1 CD cord-010119-t1x9gknd 4368 1 : : : cord-010119-t1x9gknd 4368 2 The the DT cord-010119-t1x9gknd 4368 3 patient patient NN cord-010119-t1x9gknd 4368 4 is be VBZ cord-010119-t1x9gknd 4368 5 a a DT cord-010119-t1x9gknd 4368 6 currently currently RB cord-010119-t1x9gknd 4368 7 43-year 43-year JJ cord-010119-t1x9gknd 4368 8 - - HYPH cord-010119-t1x9gknd 4368 9 old old JJ cord-010119-t1x9gknd 4368 10 female female NN cord-010119-t1x9gknd 4368 11 with with IN cord-010119-t1x9gknd 4368 12 focal focal JJ cord-010119-t1x9gknd 4368 13 segmental segmental JJ cord-010119-t1x9gknd 4368 14 glomerulosclerosis glomerulosclerosis NN cord-010119-t1x9gknd 4368 15 who who WP cord-010119-t1x9gknd 4368 16 received receive VBD cord-010119-t1x9gknd 4368 17 her -PRON- PRP$ cord-010119-t1x9gknd 4368 18 first first JJ cord-010119-t1x9gknd 4368 19 kidney kidney NN cord-010119-t1x9gknd 4368 20 transplant transplant NN cord-010119-t1x9gknd 4368 21 from from IN cord-010119-t1x9gknd 4368 22 a a DT cord-010119-t1x9gknd 4368 23 living live VBG cord-010119-t1x9gknd 4368 24 related related JJ cord-010119-t1x9gknd 4368 25 donor donor NN cord-010119-t1x9gknd 4368 26 at at IN cord-010119-t1x9gknd 4368 27 age age NN cord-010119-t1x9gknd 4368 28 22 22 CD cord-010119-t1x9gknd 4368 29 , , , cord-010119-t1x9gknd 4368 30 and and CC cord-010119-t1x9gknd 4368 31 a a DT cord-010119-t1x9gknd 4368 32 second second JJ cord-010119-t1x9gknd 4368 33 deceased deceased JJ cord-010119-t1x9gknd 4368 34 donor donor NN cord-010119-t1x9gknd 4368 35 transplant transplant NN cord-010119-t1x9gknd 4368 36 due due IN cord-010119-t1x9gknd 4368 37 to to IN cord-010119-t1x9gknd 4368 38 a a DT cord-010119-t1x9gknd 4368 39 rejection rejection NN cord-010119-t1x9gknd 4368 40 of of IN cord-010119-t1x9gknd 4368 41 the the DT cord-010119-t1x9gknd 4368 42 transplanted transplant VBN cord-010119-t1x9gknd 4368 43 kidney kidney NN cord-010119-t1x9gknd 4368 44 at at IN cord-010119-t1x9gknd 4368 45 age age NN cord-010119-t1x9gknd 4368 46 38 38 CD cord-010119-t1x9gknd 4368 47 . . . cord-010119-t1x9gknd 4369 1 Three three CD cord-010119-t1x9gknd 4369 2 years year NNS cord-010119-t1x9gknd 4369 3 post post NN cord-010119-t1x9gknd 4369 4 - - NN cord-010119-t1x9gknd 4369 5 transplant transplant NN cord-010119-t1x9gknd 4369 6 , , , cord-010119-t1x9gknd 4369 7 her -PRON- PRP$ cord-010119-t1x9gknd 4369 8 creatinine creatinine NN cord-010119-t1x9gknd 4369 9 ( ( -LRB- cord-010119-t1x9gknd 4369 10 Cr Cr NNP cord-010119-t1x9gknd 4369 11 ) ) -RRB- cord-010119-t1x9gknd 4369 12 started start VBD cord-010119-t1x9gknd 4369 13 to to TO cord-010119-t1x9gknd 4369 14 rise rise VB cord-010119-t1x9gknd 4369 15 from from IN cord-010119-t1x9gknd 4369 16 0.7 0.7 CD cord-010119-t1x9gknd 4369 17 to to IN cord-010119-t1x9gknd 4369 18 1.35 1.35 CD cord-010119-t1x9gknd 4369 19 mg mg NNP cord-010119-t1x9gknd 4369 20 / / SYM cord-010119-t1x9gknd 4369 21 dl dl NNP cord-010119-t1x9gknd 4369 22 and and CC cord-010119-t1x9gknd 4369 23 a a DT cord-010119-t1x9gknd 4369 24 biopsy biopsy NN cord-010119-t1x9gknd 4369 25 showed show VBD cord-010119-t1x9gknd 4369 26 Banff Banff NNP cord-010119-t1x9gknd 4369 27 criteria criterion NNS cord-010119-t1x9gknd 4369 28 grade grade NN cord-010119-t1x9gknd 4369 29 2 2 CD cord-010119-t1x9gknd 4369 30 AMR AMR NNP cord-010119-t1x9gknd 4369 31 , , , cord-010119-t1x9gknd 4369 32 grade grade NN cord-010119-t1x9gknd 4369 33 2A 2a CD cord-010119-t1x9gknd 4369 34 T t NN cord-010119-t1x9gknd 4369 35 - - HYPH cord-010119-t1x9gknd 4369 36 cell cell NN cord-010119-t1x9gknd 4369 37 mediated mediate VBN cord-010119-t1x9gknd 4369 38 rejection rejection NN cord-010119-t1x9gknd 4369 39 ( ( -LRB- cord-010119-t1x9gknd 4369 40 TCMR TCMR NNP cord-010119-t1x9gknd 4369 41 ) ) -RRB- cord-010119-t1x9gknd 4369 42 and and CC cord-010119-t1x9gknd 4369 43 grade grade NN cord-010119-t1x9gknd 4369 44 3 3 CD cord-010119-t1x9gknd 4369 45 interstitial interstitial JJ cord-010119-t1x9gknd 4369 46 fibrosis fibrosis NN cord-010119-t1x9gknd 4369 47 and and CC cord-010119-t1x9gknd 4369 48 tubular tubular JJ cord-010119-t1x9gknd 4369 49 atrophy atrophy NN cord-010119-t1x9gknd 4369 50 . . . cord-010119-t1x9gknd 4370 1 HLA HLA NNP cord-010119-t1x9gknd 4370 2 DSA DSA NNP cord-010119-t1x9gknd 4370 3 had have VBD cord-010119-t1x9gknd 4370 4 been be VBN cord-010119-t1x9gknd 4370 5 negative negative JJ cord-010119-t1x9gknd 4370 6 in in IN cord-010119-t1x9gknd 4370 7 serum serum NN cord-010119-t1x9gknd 4370 8 , , , cord-010119-t1x9gknd 4370 9 but but CC cord-010119-t1x9gknd 4370 10 high high JJ cord-010119-t1x9gknd 4370 11 level level NN cord-010119-t1x9gknd 4370 12 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4370 13 was be VBD cord-010119-t1x9gknd 4370 14 identified identify VBN cord-010119-t1x9gknd 4370 15 at at IN cord-010119-t1x9gknd 4370 16 > > $ cord-010119-t1x9gknd 4370 17 40 40 CD cord-010119-t1x9gknd 4370 18 U/ U/ NNP cord-010119-t1x9gknd 4370 19 ml ml XX cord-010119-t1x9gknd 4370 20 ( ( -LRB- cord-010119-t1x9gknd 4370 21 high high JJ cord-010119-t1x9gknd 4370 22 : : : cord-010119-t1x9gknd 4370 23 > > SYM cord-010119-t1x9gknd 4370 24 17 17 CD cord-010119-t1x9gknd 4370 25 U U NNP cord-010119-t1x9gknd 4370 26 / / SYM cord-010119-t1x9gknd 4370 27 ml ml XX cord-010119-t1x9gknd 4370 28 , , , cord-010119-t1x9gknd 4370 29 intermediate intermediate JJ cord-010119-t1x9gknd 4370 30 : : : cord-010119-t1x9gknd 4370 31 12 12 CD cord-010119-t1x9gknd 4370 32 - - SYM cord-010119-t1x9gknd 4370 33 17 17 CD cord-010119-t1x9gknd 4370 34 U U NNP cord-010119-t1x9gknd 4370 35 / / SYM cord-010119-t1x9gknd 4370 36 ml ml XX cord-010119-t1x9gknd 4370 37 , , , cord-010119-t1x9gknd 4370 38 negative negative JJ cord-010119-t1x9gknd 4370 39 : : : cord-010119-t1x9gknd 4370 40 < < XX cord-010119-t1x9gknd 4370 41 12 12 CD cord-010119-t1x9gknd 4370 42 U U NNP cord-010119-t1x9gknd 4370 43 / / SYM cord-010119-t1x9gknd 4370 44 ml ml NN cord-010119-t1x9gknd 4370 45 ) ) -RRB- cord-010119-t1x9gknd 4370 46 . . . cord-010119-t1x9gknd 4371 1 She -PRON- PRP cord-010119-t1x9gknd 4371 2 received receive VBD cord-010119-t1x9gknd 4371 3 6 6 CD cord-010119-t1x9gknd 4371 4 TPE TPE NNP cord-010119-t1x9gknd 4371 5 treatments treatment NNS cord-010119-t1x9gknd 4371 6 every every DT cord-010119-t1x9gknd 4371 7 other other JJ cord-010119-t1x9gknd 4371 8 day day NN cord-010119-t1x9gknd 4371 9 and and CC cord-010119-t1x9gknd 4371 10 started start VBD cord-010119-t1x9gknd 4371 11 losartan losartan NNP cord-010119-t1x9gknd 4371 12 . . . cord-010119-t1x9gknd 4372 1 After after IN cord-010119-t1x9gknd 4372 2 a a DT cord-010119-t1x9gknd 4372 3 course course NN cord-010119-t1x9gknd 4372 4 of of IN cord-010119-t1x9gknd 4372 5 TPE TPE NNP cord-010119-t1x9gknd 4372 6 , , , cord-010119-t1x9gknd 4372 7 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4372 8 decreased decrease VBD cord-010119-t1x9gknd 4372 9 to to IN cord-010119-t1x9gknd 4372 10 32 32 CD cord-010119-t1x9gknd 4372 11 U u NN cord-010119-t1x9gknd 4372 12 / / SYM cord-010119-t1x9gknd 4372 13 ml ml NN cord-010119-t1x9gknd 4372 14 and and CC cord-010119-t1x9gknd 4372 15 histology histology NN cord-010119-t1x9gknd 4372 16 showed show VBD cord-010119-t1x9gknd 4372 17 improvement improvement NN cord-010119-t1x9gknd 4372 18 of of IN cord-010119-t1x9gknd 4372 19 AMR AMR NNP cord-010119-t1x9gknd 4372 20 and and CC cord-010119-t1x9gknd 4372 21 TCMR TCMR NNP cord-010119-t1x9gknd 4372 22 , , , cord-010119-t1x9gknd 4372 23 however however RB cord-010119-t1x9gknd 4372 24 , , , cord-010119-t1x9gknd 4372 25 Cr Cr NNP cord-010119-t1x9gknd 4372 26 kept keep VBD cord-010119-t1x9gknd 4372 27 increasing increase VBG cord-010119-t1x9gknd 4372 28 slowly slowly RB cord-010119-t1x9gknd 4372 29 to to IN cord-010119-t1x9gknd 4372 30 1.9 1.9 CD cord-010119-t1x9gknd 4372 31 ml ml NNS cord-010119-t1x9gknd 4372 32 / / SYM cord-010119-t1x9gknd 4372 33 dl dl NN cord-010119-t1x9gknd 4372 34 . . . cord-010119-t1x9gknd 4373 1 In in IN cord-010119-t1x9gknd 4373 2 one one CD cord-010119-t1x9gknd 4373 3 month month NN cord-010119-t1x9gknd 4373 4 , , , cord-010119-t1x9gknd 4373 5 her -PRON- PRP cord-010119-t1x9gknd 4373 6 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4373 7 increased increase VBD cord-010119-t1x9gknd 4373 8 again again RB cord-010119-t1x9gknd 4373 9 to to IN cord-010119-t1x9gknd 4373 10 > > XX cord-010119-t1x9gknd 4373 11 40 40 CD cord-010119-t1x9gknd 4373 12 U u NN cord-010119-t1x9gknd 4373 13 / / SYM cord-010119-t1x9gknd 4373 14 ml ml NNS cord-010119-t1x9gknd 4373 15 , , , cord-010119-t1x9gknd 4373 16 therefore therefore RB cord-010119-t1x9gknd 4373 17 , , , cord-010119-t1x9gknd 4373 18 she -PRON- PRP cord-010119-t1x9gknd 4373 19 received receive VBD cord-010119-t1x9gknd 4373 20 3 3 CD cord-010119-t1x9gknd 4373 21 more more JJR cord-010119-t1x9gknd 4373 22 TPE tpe NN cord-010119-t1x9gknd 4373 23 treatments treatment NNS cord-010119-t1x9gknd 4373 24 with with IN cord-010119-t1x9gknd 4373 25 a a DT cord-010119-t1x9gknd 4373 26 decrease decrease NN cord-010119-t1x9gknd 4373 27 in in IN cord-010119-t1x9gknd 4373 28 her -PRON- PRP cord-010119-t1x9gknd 4373 29 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4373 30 to to IN cord-010119-t1x9gknd 4373 31 16 16 CD cord-010119-t1x9gknd 4373 32 U u NN cord-010119-t1x9gknd 4373 33 / / SYM cord-010119-t1x9gknd 4373 34 ml ml NN cord-010119-t1x9gknd 4373 35 . . . cord-010119-t1x9gknd 4374 1 Although although IN cord-010119-t1x9gknd 4374 2 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4374 3 level level NN cord-010119-t1x9gknd 4374 4 increased increase VBD cord-010119-t1x9gknd 4374 5 slightly slightly RB cord-010119-t1x9gknd 4374 6 to to IN cord-010119-t1x9gknd 4374 7 20 20 CD cord-010119-t1x9gknd 4374 8 U u NN cord-010119-t1x9gknd 4374 9 / / SYM cord-010119-t1x9gknd 4374 10 ml ml NN cord-010119-t1x9gknd 4374 11 after after IN cord-010119-t1x9gknd 4374 12 3 3 CD cord-010119-t1x9gknd 4374 13 months month NNS cord-010119-t1x9gknd 4374 14 , , , cord-010119-t1x9gknd 4374 15 her -PRON- PRP$ cord-010119-t1x9gknd 4374 16 Cr Cr NNP cord-010119-t1x9gknd 4374 17 has have VBZ cord-010119-t1x9gknd 4374 18 been be VBN cord-010119-t1x9gknd 4374 19 stable stable JJ cord-010119-t1x9gknd 4374 20 at at IN cord-010119-t1x9gknd 4374 21 1.3 1.3 CD cord-010119-t1x9gknd 4374 22 - - SYM cord-010119-t1x9gknd 4374 23 1.6 1.6 CD cord-010119-t1x9gknd 4374 24 ml ml NNS cord-010119-t1x9gknd 4374 25 / / SYM cord-010119-t1x9gknd 4374 26 dl dl NN cord-010119-t1x9gknd 4374 27 . . . cord-010119-t1x9gknd 4375 1 Case case NN cord-010119-t1x9gknd 4375 2 2 2 CD cord-010119-t1x9gknd 4376 1 : : : cord-010119-t1x9gknd 4376 2 The the DT cord-010119-t1x9gknd 4376 3 patient patient NN cord-010119-t1x9gknd 4376 4 is be VBZ cord-010119-t1x9gknd 4376 5 a a DT cord-010119-t1x9gknd 4376 6 25-year 25-year JJ cord-010119-t1x9gknd 4376 7 - - HYPH cord-010119-t1x9gknd 4376 8 old old JJ cord-010119-t1x9gknd 4376 9 Mean mean JJ cord-010119-t1x9gknd 4376 10 1/-SE 1/-se CD cord-010119-t1x9gknd 4377 1 -54.71/-12.9 -54.71/-12.9 IN cord-010119-t1x9gknd 4377 2 % % NN cord-010119-t1x9gknd 4377 3 * * NFP cord-010119-t1x9gknd 4377 4 183.1%1/-12.8 183.1%1/-12.8 CD cord-010119-t1x9gknd 4377 5 % % NN cord-010119-t1x9gknd 4378 1 * * NFP cord-010119-t1x9gknd 4378 2 * * NFP cord-010119-t1x9gknd 4378 3 p<0.05 p<0.05 JJ cord-010119-t1x9gknd 4378 4 96A 96a CD cord-010119-t1x9gknd 4378 5 female female NN cord-010119-t1x9gknd 4378 6 with with IN cord-010119-t1x9gknd 4378 7 malignant malignant JJ cord-010119-t1x9gknd 4378 8 hypertension hypertension NN cord-010119-t1x9gknd 4378 9 who who WP cord-010119-t1x9gknd 4378 10 received receive VBD cord-010119-t1x9gknd 4378 11 a a DT cord-010119-t1x9gknd 4378 12 deceased deceased JJ cord-010119-t1x9gknd 4378 13 donor donor NN cord-010119-t1x9gknd 4378 14 kidney kidney NN cord-010119-t1x9gknd 4378 15 transplant transplant NN cord-010119-t1x9gknd 4378 16 at at IN cord-010119-t1x9gknd 4378 17 age age NN cord-010119-t1x9gknd 4378 18 24 24 CD cord-010119-t1x9gknd 4378 19 . . . cord-010119-t1x9gknd 4379 1 Her -PRON- PRP$ cord-010119-t1x9gknd 4379 2 Cr cr NN cord-010119-t1x9gknd 4379 3 started start VBD cord-010119-t1x9gknd 4379 4 to to TO cord-010119-t1x9gknd 4379 5 rise rise VB cord-010119-t1x9gknd 4379 6 2 2 CD cord-010119-t1x9gknd 4379 7 weeks week NNS cord-010119-t1x9gknd 4379 8 post post NN cord-010119-t1x9gknd 4379 9 - - NN cord-010119-t1x9gknd 4379 10 transplant transplant NN cord-010119-t1x9gknd 4379 11 from from IN cord-010119-t1x9gknd 4379 12 1.4 1.4 CD cord-010119-t1x9gknd 4379 13 to to IN cord-010119-t1x9gknd 4379 14 2.68 2.68 CD cord-010119-t1x9gknd 4379 15 mg mg NNP cord-010119-t1x9gknd 4379 16 / / SYM cord-010119-t1x9gknd 4379 17 dl dl NNP cord-010119-t1x9gknd 4379 18 without without IN cord-010119-t1x9gknd 4379 19 detectable detectable JJ cord-010119-t1x9gknd 4379 20 HLA HLA NNP cord-010119-t1x9gknd 4379 21 DSA DSA NNP cord-010119-t1x9gknd 4379 22 . . . cord-010119-t1x9gknd 4380 1 Although although IN cord-010119-t1x9gknd 4380 2 biopsy biopsy NN cord-010119-t1x9gknd 4380 3 showed show VBD cord-010119-t1x9gknd 4380 4 no no DT cord-010119-t1x9gknd 4380 5 AMR AMR NNP cord-010119-t1x9gknd 4380 6 or or CC cord-010119-t1x9gknd 4380 7 TCMR TCMR NNP cord-010119-t1x9gknd 4380 8 , , , cord-010119-t1x9gknd 4380 9 there there EX cord-010119-t1x9gknd 4380 10 was be VBD cord-010119-t1x9gknd 4380 11 focally focally RB cord-010119-t1x9gknd 4380 12 severe severe JJ cord-010119-t1x9gknd 4380 13 arteriopathy arteriopathy NN cord-010119-t1x9gknd 4380 14 . . . cord-010119-t1x9gknd 4381 1 She -PRON- PRP cord-010119-t1x9gknd 4381 2 was be VBD cord-010119-t1x9gknd 4381 3 found find VBN cord-010119-t1x9gknd 4381 4 to to TO cord-010119-t1x9gknd 4381 5 have have VB cord-010119-t1x9gknd 4381 6 high high JJ cord-010119-t1x9gknd 4381 7 AT1RAb at1rab CD cord-010119-t1x9gknd 4381 8 level level NN cord-010119-t1x9gknd 4381 9 at at IN cord-010119-t1x9gknd 4381 10 18 18 CD cord-010119-t1x9gknd 4381 11 U u NN cord-010119-t1x9gknd 4381 12 / / SYM cord-010119-t1x9gknd 4381 13 ml ml NN cord-010119-t1x9gknd 4381 14 . . . cord-010119-t1x9gknd 4382 1 She -PRON- PRP cord-010119-t1x9gknd 4382 2 received receive VBD cord-010119-t1x9gknd 4382 3 6 6 CD cord-010119-t1x9gknd 4382 4 TPE TPE NNP cord-010119-t1x9gknd 4382 5 procedures procedure NNS cord-010119-t1x9gknd 4383 1 every every DT cord-010119-t1x9gknd 4383 2 other other JJ cord-010119-t1x9gknd 4383 3 day day NN cord-010119-t1x9gknd 4383 4 and and CC cord-010119-t1x9gknd 4383 5 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4383 6 decreased decrease VBD cord-010119-t1x9gknd 4383 7 to to IN cord-010119-t1x9gknd 4383 8 8 8 CD cord-010119-t1x9gknd 4383 9 U u NN cord-010119-t1x9gknd 4383 10 / / CC cord-010119-t1x9gknd 4383 11 ml ml XX cord-010119-t1x9gknd 4383 12 with with IN cord-010119-t1x9gknd 4383 13 a a DT cord-010119-t1x9gknd 4383 14 decrease decrease NN cord-010119-t1x9gknd 4383 15 of of IN cord-010119-t1x9gknd 4383 16 Cr Cr NNP cord-010119-t1x9gknd 4383 17 to to IN cord-010119-t1x9gknd 4383 18 1.98 1.98 CD cord-010119-t1x9gknd 4383 19 mg mg NNP cord-010119-t1x9gknd 4383 20 / / SYM cord-010119-t1x9gknd 4383 21 dl dl NNP cord-010119-t1x9gknd 4383 22 and and CC cord-010119-t1x9gknd 4383 23 improved improve VBD cord-010119-t1x9gknd 4383 24 arteriopathy arteriopathy NNP cord-010119-t1x9gknd 4383 25 in in IN cord-010119-t1x9gknd 4383 26 histology histology NN cord-010119-t1x9gknd 4383 27 . . . cord-010119-t1x9gknd 4384 1 Because because IN cord-010119-t1x9gknd 4384 2 her -PRON- PRP$ cord-010119-t1x9gknd 4384 3 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4384 4 level level NN cord-010119-t1x9gknd 4384 5 slightly slightly RB cord-010119-t1x9gknd 4384 6 increased increase VBD cord-010119-t1x9gknd 4384 7 to to IN cord-010119-t1x9gknd 4384 8 12 12 CD cord-010119-t1x9gknd 4384 9 U u NN cord-010119-t1x9gknd 4384 10 / / SYM cord-010119-t1x9gknd 4384 11 ml ml NN cord-010119-t1x9gknd 4384 12 over over IN cord-010119-t1x9gknd 4384 13 the the DT cord-010119-t1x9gknd 4384 14 next next JJ cord-010119-t1x9gknd 4384 15 2 2 CD cord-010119-t1x9gknd 4384 16 weeks week NNS cord-010119-t1x9gknd 4384 17 , , , cord-010119-t1x9gknd 4384 18 she -PRON- PRP cord-010119-t1x9gknd 4384 19 started start VBD cord-010119-t1x9gknd 4384 20 weekly weekly JJ cord-010119-t1x9gknd 4384 21 TPE TPE NNP cord-010119-t1x9gknd 4384 22 treatment treatment NN cord-010119-t1x9gknd 4384 23 . . . cord-010119-t1x9gknd 4385 1 After after IN cord-010119-t1x9gknd 4385 2 5 5 CD cord-010119-t1x9gknd 4385 3 weekly weekly JJ cord-010119-t1x9gknd 4385 4 TPE TPE NNP cord-010119-t1x9gknd 4385 5 , , , cord-010119-t1x9gknd 4385 6 TPE TPE NNP cord-010119-t1x9gknd 4385 7 treatment treatment NN cord-010119-t1x9gknd 4385 8 was be VBD cord-010119-t1x9gknd 4385 9 stopped stop VBN cord-010119-t1x9gknd 4385 10 because because IN cord-010119-t1x9gknd 4385 11 her -PRON- PRP$ cord-010119-t1x9gknd 4385 12 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4385 13 level level NN cord-010119-t1x9gknd 4385 14 remained remain VBD cord-010119-t1x9gknd 4385 15 relatively relatively RB cord-010119-t1x9gknd 4385 16 unchanged unchanged JJ cord-010119-t1x9gknd 4385 17 . . . cord-010119-t1x9gknd 4386 1 Her -PRON- PRP$ cord-010119-t1x9gknd 4386 2 Cr cr NN cord-010119-t1x9gknd 4386 3 has have VBZ cord-010119-t1x9gknd 4386 4 been be VBN cord-010119-t1x9gknd 4386 5 stable stable JJ cord-010119-t1x9gknd 4386 6 at at IN cord-010119-t1x9gknd 4386 7 around around IN cord-010119-t1x9gknd 4386 8 1.5 1.5 CD cord-010119-t1x9gknd 4386 9 ml ml NNS cord-010119-t1x9gknd 4386 10 / / SYM cord-010119-t1x9gknd 4386 11 dl dl NN cord-010119-t1x9gknd 4386 12 to to IN cord-010119-t1x9gknd 4386 13 date date NN cord-010119-t1x9gknd 4386 14 . . . cord-010119-t1x9gknd 4387 1 Conclusion conclusion NN cord-010119-t1x9gknd 4387 2 : : : cord-010119-t1x9gknd 4387 3 We -PRON- PRP cord-010119-t1x9gknd 4387 4 present present VBP cord-010119-t1x9gknd 4387 5 2 2 CD cord-010119-t1x9gknd 4387 6 kidney kidney NN cord-010119-t1x9gknd 4387 7 transplant transplant NN cord-010119-t1x9gknd 4387 8 recipients recipient NNS cord-010119-t1x9gknd 4387 9 who who WP cord-010119-t1x9gknd 4387 10 received receive VBD cord-010119-t1x9gknd 4387 11 TPE TPE NNP cord-010119-t1x9gknd 4387 12 treatments treatment NNS cord-010119-t1x9gknd 4387 13 for for IN cord-010119-t1x9gknd 4387 14 high high JJ cord-010119-t1x9gknd 4387 15 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4387 16 levels level NNS cord-010119-t1x9gknd 4387 17 . . . cord-010119-t1x9gknd 4388 1 A a DT cord-010119-t1x9gknd 4388 2 course course NN cord-010119-t1x9gknd 4388 3 of of IN cord-010119-t1x9gknd 4388 4 TPE tpe NN cord-010119-t1x9gknd 4388 5 procedures procedure NNS cord-010119-t1x9gknd 4388 6 followed follow VBN cord-010119-t1x9gknd 4388 7 by by IN cord-010119-t1x9gknd 4388 8 IVIG IVIG NNP cord-010119-t1x9gknd 4388 9 every every DT cord-010119-t1x9gknd 4388 10 other other JJ cord-010119-t1x9gknd 4388 11 day day NN cord-010119-t1x9gknd 4388 12 was be VBD cord-010119-t1x9gknd 4388 13 effective effective JJ cord-010119-t1x9gknd 4388 14 to to TO cord-010119-t1x9gknd 4388 15 decrease decrease VB cord-010119-t1x9gknd 4388 16 AT1RAb AT1RAb NNP cord-010119-t1x9gknd 4388 17 levels level NNS cord-010119-t1x9gknd 4388 18 ; ; : cord-010119-t1x9gknd 4388 19 however however RB cord-010119-t1x9gknd 4388 20 , , , cord-010119-t1x9gknd 4388 21 weekly weekly JJ cord-010119-t1x9gknd 4388 22 TPE TPE NNP cord-010119-t1x9gknd 4388 23 had have VBD cord-010119-t1x9gknd 4388 24 no no DT cord-010119-t1x9gknd 4388 25 effect effect NN cord-010119-t1x9gknd 4388 26 on on IN cord-010119-t1x9gknd 4388 27 reducing reduce VBG cord-010119-t1x9gknd 4388 28 AT1RAbs at1rabs NN cord-010119-t1x9gknd 4388 29 . . . cord-010119-t1x9gknd 4389 1 TPE TPE NNP cord-010119-t1x9gknd 4389 2 treatment treatment NN cord-010119-t1x9gknd 4389 3 may may MD cord-010119-t1x9gknd 4389 4 be be VB cord-010119-t1x9gknd 4389 5 also also RB cord-010119-t1x9gknd 4389 6 beneficial beneficial JJ cord-010119-t1x9gknd 4389 7 to to TO cord-010119-t1x9gknd 4389 8 improve improve VB cord-010119-t1x9gknd 4389 9 histological histological JJ cord-010119-t1x9gknd 4389 10 AMR AMR NNP cord-010119-t1x9gknd 4389 11 and and CC cord-010119-t1x9gknd 4389 12 clinical clinical JJ cord-010119-t1x9gknd 4389 13 kidney kidney NN cord-010119-t1x9gknd 4389 14 function function NN cord-010119-t1x9gknd 4389 15 . . . cord-010119-t1x9gknd 4390 1 Experience experience NN cord-010119-t1x9gknd 4390 2 in in IN cord-010119-t1x9gknd 4390 3 Management Management NNP cord-010119-t1x9gknd 4390 4 of of IN cord-010119-t1x9gknd 4390 5 Thyroid Thyroid NNP cord-010119-t1x9gknd 4390 6 Storm Storm NNP cord-010119-t1x9gknd 4390 7 By by IN cord-010119-t1x9gknd 4390 8 Plasmapheresis Plasmapheresis NNP cord-010119-t1x9gknd 4390 9 Tatiana Tatiana NNP cord-010119-t1x9gknd 4390 10 Belousova Belousova NNP cord-010119-t1x9gknd 4390 11 * * NFP cord-010119-t1x9gknd 4390 12 , , , cord-010119-t1x9gknd 4390 13 Vanya Vanya NNP cord-010119-t1x9gknd 4390 14 Jaitly Jaitly NNP cord-010119-t1x9gknd 4390 15 , , , cord-010119-t1x9gknd 4390 16 Brian Brian NNP cord-010119-t1x9gknd 4390 17 Castillo Castillo NNP cord-010119-t1x9gknd 4390 18 , , , cord-010119-t1x9gknd 4390 19 Hlaing Hlaing NNP cord-010119-t1x9gknd 4390 20 Tint Tint NNP cord-010119-t1x9gknd 4390 21 , , , cord-010119-t1x9gknd 4390 22 Kimberly Kimberly NNP cord-010119-t1x9gknd 4390 23 Klein Klein NNP cord-010119-t1x9gknd 4390 24 and and CC cord-010119-t1x9gknd 4390 25 Yu Yu NNP cord-010119-t1x9gknd 4390 26 Bai Bai NNP cord-010119-t1x9gknd 4390 27 . . . cord-010119-t1x9gknd 4391 1 University University NNP cord-010119-t1x9gknd 4391 2 of of IN cord-010119-t1x9gknd 4391 3 Texas Texas NNP cord-010119-t1x9gknd 4391 4 Health Health NNP cord-010119-t1x9gknd 4391 5 sciences sciences NNPS cord-010119-t1x9gknd 4391 6 center center NN cord-010119-t1x9gknd 4391 7 at at IN cord-010119-t1x9gknd 4391 8 Houston Houston NNP cord-010119-t1x9gknd 4391 9 Background Background NNP cord-010119-t1x9gknd 4391 10 / / SYM cord-010119-t1x9gknd 4391 11 Case Case NNP cord-010119-t1x9gknd 4391 12 Studies Studies NNPS cord-010119-t1x9gknd 4391 13 : : : cord-010119-t1x9gknd 4391 14 Thyroid thyroid NN cord-010119-t1x9gknd 4391 15 storm storm NN cord-010119-t1x9gknd 4391 16 ( ( -LRB- cord-010119-t1x9gknd 4391 17 TS TS NNP cord-010119-t1x9gknd 4391 18 ) ) -RRB- cord-010119-t1x9gknd 4391 19 is be VBZ cord-010119-t1x9gknd 4391 20 an an DT cord-010119-t1x9gknd 4391 21 extreme extreme JJ cord-010119-t1x9gknd 4391 22 manifestation manifestation NN cord-010119-t1x9gknd 4391 23 of of IN cord-010119-t1x9gknd 4391 24 thyrotoxicosis thyrotoxicosis NN cord-010119-t1x9gknd 4391 25 that that WDT cord-010119-t1x9gknd 4391 26 is be VBZ cord-010119-t1x9gknd 4391 27 a a DT cord-010119-t1x9gknd 4391 28 serious serious JJ cord-010119-t1x9gknd 4391 29 complication complication NN cord-010119-t1x9gknd 4391 30 occurring occur VBG cord-010119-t1x9gknd 4391 31 primarily primarily RB cord-010119-t1x9gknd 4391 32 in in IN cord-010119-t1x9gknd 4391 33 patients patient NNS cord-010119-t1x9gknd 4391 34 with with IN cord-010119-t1x9gknd 4391 35 Graves Graves NNPS cord-010119-t1x9gknd 4391 36 ' ' POS cord-010119-t1x9gknd 4391 37 disease disease NN cord-010119-t1x9gknd 4391 38 . . . cord-010119-t1x9gknd 4392 1 Clinically clinically RB cord-010119-t1x9gknd 4392 2 they -PRON- PRP cord-010119-t1x9gknd 4392 3 may may MD cord-010119-t1x9gknd 4392 4 present present VB cord-010119-t1x9gknd 4392 5 with with IN cord-010119-t1x9gknd 4392 6 a a DT cord-010119-t1x9gknd 4392 7 wide wide JJ cord-010119-t1x9gknd 4392 8 range range NN cord-010119-t1x9gknd 4392 9 of of IN cord-010119-t1x9gknd 4392 10 hypermetabolic hypermetabolic NN cord-010119-t1x9gknd 4392 11 symptoms symptom NNS cord-010119-t1x9gknd 4392 12 which which WDT cord-010119-t1x9gknd 4392 13 may may MD cord-010119-t1x9gknd 4392 14 be be VB cord-010119-t1x9gknd 4392 15 fatal fatal JJ cord-010119-t1x9gknd 4392 16 if if IN cord-010119-t1x9gknd 4392 17 not not RB cord-010119-t1x9gknd 4392 18 managed manage VBN cord-010119-t1x9gknd 4392 19 appropriately appropriately RB cord-010119-t1x9gknd 4392 20 . . . cord-010119-t1x9gknd 4393 1 We -PRON- PRP cord-010119-t1x9gknd 4393 2 report report VBP cord-010119-t1x9gknd 4393 3 two two CD cord-010119-t1x9gknd 4393 4 cases case NNS cord-010119-t1x9gknd 4393 5 where where WRB cord-010119-t1x9gknd 4393 6 TS TS NNP cord-010119-t1x9gknd 4393 7 with with IN cord-010119-t1x9gknd 4393 8 severe severe JJ cord-010119-t1x9gknd 4393 9 cardiac cardiac JJ cord-010119-t1x9gknd 4393 10 complications complication NNS cord-010119-t1x9gknd 4393 11 was be VBD cord-010119-t1x9gknd 4393 12 managed manage VBN cord-010119-t1x9gknd 4393 13 by by IN cord-010119-t1x9gknd 4393 14 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 4393 15 ( ( -LRB- cord-010119-t1x9gknd 4393 16 PLEX PLEX NNP cord-010119-t1x9gknd 4393 17 ) ) -RRB- cord-010119-t1x9gknd 4393 18 with with IN cord-010119-t1x9gknd 4393 19 excellent excellent JJ cord-010119-t1x9gknd 4393 20 effect effect NN cord-010119-t1x9gknd 4393 21 . . . cord-010119-t1x9gknd 4394 1 Study Study NNP cord-010119-t1x9gknd 4394 2 Design Design NNP cord-010119-t1x9gknd 4394 3 / / SYM cord-010119-t1x9gknd 4394 4 Method method NN cord-010119-t1x9gknd 4394 5 : : : cord-010119-t1x9gknd 4395 1 A a DT cord-010119-t1x9gknd 4395 2 36 36 CD cord-010119-t1x9gknd 4395 3 year year NN cord-010119-t1x9gknd 4395 4 old old JJ cord-010119-t1x9gknd 4395 5 man man NN cord-010119-t1x9gknd 4395 6 ( ( -LRB- cord-010119-t1x9gknd 4395 7 Patient Patient NNP cord-010119-t1x9gknd 4395 8 A A NNP cord-010119-t1x9gknd 4395 9 ) ) -RRB- cord-010119-t1x9gknd 4395 10 with with IN cord-010119-t1x9gknd 4395 11 a a DT cord-010119-t1x9gknd 4395 12 medical medical JJ cord-010119-t1x9gknd 4395 13 history history NN cord-010119-t1x9gknd 4395 14 of of IN cord-010119-t1x9gknd 4395 15 hyperthyroidism hyperthyroidism NN cord-010119-t1x9gknd 4395 16 present present JJ cord-010119-t1x9gknd 4395 17 with with IN cord-010119-t1x9gknd 4395 18 TS TS NNP cord-010119-t1x9gknd 4395 19 complicated complicate VBN cord-010119-t1x9gknd 4395 20 with with IN cord-010119-t1x9gknd 4395 21 cardiogenic cardiogenic JJ cord-010119-t1x9gknd 4395 22 shock shock NN cord-010119-t1x9gknd 4395 23 [ [ -LRB- cord-010119-t1x9gknd 4395 24 Ejection ejection NN cord-010119-t1x9gknd 4395 25 Fraction Fraction NNP cord-010119-t1x9gknd 4395 26 ( ( -LRB- cord-010119-t1x9gknd 4395 27 EF EF NNP cord-010119-t1x9gknd 4395 28 ) ) -RRB- cord-010119-t1x9gknd 4395 29 < < XX cord-010119-t1x9gknd 4395 30 10 10 CD cord-010119-t1x9gknd 4395 31 % % NN cord-010119-t1x9gknd 4395 32 ] ] -RRB- cord-010119-t1x9gknd 4395 33 , , , cord-010119-t1x9gknd 4395 34 renal renal JJ cord-010119-t1x9gknd 4395 35 and and CC cord-010119-t1x9gknd 4395 36 hepatic hepatic JJ cord-010119-t1x9gknd 4395 37 dysfunction dysfunction NN cord-010119-t1x9gknd 4395 38 as as RB cord-010119-t1x9gknd 4395 39 well well RB cord-010119-t1x9gknd 4395 40 as as IN cord-010119-t1x9gknd 4395 41 coagulopathy coagulopathy NN cord-010119-t1x9gknd 4395 42 . . . cord-010119-t1x9gknd 4396 1 Patient Patient NNP cord-010119-t1x9gknd 4396 2 was be VBD cord-010119-t1x9gknd 4396 3 persistent persistent JJ cord-010119-t1x9gknd 4396 4 tachycardic tachycardic JJ cord-010119-t1x9gknd 4396 5 while while IN cord-010119-t1x9gknd 4396 6 being be VBG cord-010119-t1x9gknd 4396 7 intubated intubate VBN cord-010119-t1x9gknd 4396 8 , , , cord-010119-t1x9gknd 4396 9 sedated sedated JJ cord-010119-t1x9gknd 4396 10 and and CC cord-010119-t1x9gknd 4396 11 requiring require VBG cord-010119-t1x9gknd 4396 12 Tandem tandem JJ cord-010119-t1x9gknd 4396 13 heart heart NN cord-010119-t1x9gknd 4396 14 support support NN cord-010119-t1x9gknd 4396 15 . . . cord-010119-t1x9gknd 4397 1 A a DT cord-010119-t1x9gknd 4397 2 33 33 CD cord-010119-t1x9gknd 4397 3 year year NN cord-010119-t1x9gknd 4397 4 old old JJ cord-010119-t1x9gknd 4397 5 man man NN cord-010119-t1x9gknd 4397 6 ( ( -LRB- cord-010119-t1x9gknd 4397 7 Patient Patient NNP cord-010119-t1x9gknd 4397 8 B B NNP cord-010119-t1x9gknd 4397 9 ) ) -RRB- cord-010119-t1x9gknd 4397 10 with with IN cord-010119-t1x9gknd 4397 11 a a DT cord-010119-t1x9gknd 4397 12 medical medical JJ cord-010119-t1x9gknd 4397 13 history history NN cord-010119-t1x9gknd 4397 14 of of IN cord-010119-t1x9gknd 4397 15 hypothyroidism hypothyroidism NN cord-010119-t1x9gknd 4397 16 ( ( -LRB- cord-010119-t1x9gknd 4397 17 on on IN cord-010119-t1x9gknd 4397 18 Synthroid Synthroid NNP cord-010119-t1x9gknd 4397 19 for for IN cord-010119-t1x9gknd 4397 20 2 2 CD cord-010119-t1x9gknd 4397 21 years year NNS cord-010119-t1x9gknd 4397 22 ) ) -RRB- cord-010119-t1x9gknd 4397 23 , , , cord-010119-t1x9gknd 4397 24 end end JJ cord-010119-t1x9gknd 4397 25 stage stage NN cord-010119-t1x9gknd 4397 26 renal renal JJ cord-010119-t1x9gknd 4397 27 disease disease NN cord-010119-t1x9gknd 4397 28 and and CC cord-010119-t1x9gknd 4397 29 non non JJ cord-010119-t1x9gknd 4397 30 - - JJ cord-010119-t1x9gknd 4397 31 ischemic ischemic JJ cord-010119-t1x9gknd 4397 32 cardiomyopathy cardiomyopathy NN cord-010119-t1x9gknd 4397 33 ( ( -LRB- cord-010119-t1x9gknd 4397 34 EF EF NNP cord-010119-t1x9gknd 4397 35 of of IN cord-010119-t1x9gknd 4397 36 20 20 CD cord-010119-t1x9gknd 4397 37 - - SYM cord-010119-t1x9gknd 4397 38 25 25 CD cord-010119-t1x9gknd 4397 39 % % NN cord-010119-t1x9gknd 4397 40 ) ) -RRB- cord-010119-t1x9gknd 4397 41 presented present VBN cord-010119-t1x9gknd 4397 42 for for IN cord-010119-t1x9gknd 4397 43 evaluation evaluation NN cord-010119-t1x9gknd 4397 44 of of IN cord-010119-t1x9gknd 4397 45 dual dual JJ cord-010119-t1x9gknd 4397 46 kidney kidney NN cord-010119-t1x9gknd 4397 47 - - HYPH cord-010119-t1x9gknd 4397 48 heart heart NN cord-010119-t1x9gknd 4397 49 transplant transplant NN cord-010119-t1x9gknd 4397 50 . . . cord-010119-t1x9gknd 4398 1 He -PRON- PRP cord-010119-t1x9gknd 4398 2 subsequently subsequently RB cord-010119-t1x9gknd 4398 3 developed develop VBD cord-010119-t1x9gknd 4398 4 TS TS NNP cord-010119-t1x9gknd 4398 5 with with IN cord-010119-t1x9gknd 4398 6 multiorgan multiorgan NNP cord-010119-t1x9gknd 4398 7 failure failure NN cord-010119-t1x9gknd 4398 8 . . . cord-010119-t1x9gknd 4399 1 Standard standard JJ cord-010119-t1x9gknd 4399 2 steroid steroid JJ cord-010119-t1x9gknd 4399 3 medication medication NN cord-010119-t1x9gknd 4399 4 treatment treatment NN cord-010119-t1x9gknd 4399 5 showed show VBD cord-010119-t1x9gknd 4399 6 little little JJ cord-010119-t1x9gknd 4399 7 response response NN cord-010119-t1x9gknd 4399 8 . . . cord-010119-t1x9gknd 4400 1 Results/ Results/ . cord-010119-t1x9gknd 4401 1 Finding find VBG cord-010119-t1x9gknd 4401 2 : : : cord-010119-t1x9gknd 4401 3 Both both DT cord-010119-t1x9gknd 4401 4 patients patient NNS cord-010119-t1x9gknd 4401 5 underwent undergo VBD cord-010119-t1x9gknd 4401 6 urgent urgent JJ cord-010119-t1x9gknd 4401 7 PLEX PLEX NNP cord-010119-t1x9gknd 4401 8 along along IN cord-010119-t1x9gknd 4401 9 with with IN cord-010119-t1x9gknd 4401 10 standard standard JJ cord-010119-t1x9gknd 4401 11 medication medication NN cord-010119-t1x9gknd 4401 12 administration administration NN cord-010119-t1x9gknd 4401 13 as as RB cord-010119-t1x9gknd 4401 14 soon soon RB cord-010119-t1x9gknd 4401 15 as as IN cord-010119-t1x9gknd 4401 16 the the DT cord-010119-t1x9gknd 4401 17 clinical clinical JJ cord-010119-t1x9gknd 4401 18 suspicion suspicion NN cord-010119-t1x9gknd 4401 19 of of IN cord-010119-t1x9gknd 4401 20 thyroid thyroid NN cord-010119-t1x9gknd 4401 21 storm storm NN cord-010119-t1x9gknd 4401 22 was be VBD cord-010119-t1x9gknd 4401 23 raised raise VBN cord-010119-t1x9gknd 4401 24 . . . cord-010119-t1x9gknd 4402 1 A a DT cord-010119-t1x9gknd 4402 2 1 1 CD cord-010119-t1x9gknd 4402 3 - - SYM cord-010119-t1x9gknd 4402 4 1.5 1.5 CD cord-010119-t1x9gknd 4402 5 plasma plasma NN cord-010119-t1x9gknd 4402 6 volume volume NN cord-010119-t1x9gknd 4402 7 , , , cord-010119-t1x9gknd 4402 8 iso iso NN cord-010119-t1x9gknd 4402 9 - - HYPH cord-010119-t1x9gknd 4402 10 volumic volumic NN cord-010119-t1x9gknd 4402 11 procedure procedure NN cord-010119-t1x9gknd 4402 12 using use VBG cord-010119-t1x9gknd 4402 13 fresh fresh JJ cord-010119-t1x9gknd 4402 14 frozen frozen JJ cord-010119-t1x9gknd 4402 15 plasma plasma NN cord-010119-t1x9gknd 4402 16 as as IN cord-010119-t1x9gknd 4402 17 replacement replacement NN cord-010119-t1x9gknd 4402 18 was be VBD cord-010119-t1x9gknd 4402 19 performed perform VBN cord-010119-t1x9gknd 4402 20 in in IN cord-010119-t1x9gknd 4402 21 the the DT cord-010119-t1x9gknd 4402 22 intensive intensive JJ cord-010119-t1x9gknd 4402 23 care care NN cord-010119-t1x9gknd 4402 24 unit unit NN cord-010119-t1x9gknd 4402 25 where where WRB cord-010119-t1x9gknd 4402 26 the the DT cord-010119-t1x9gknd 4402 27 procedure procedure NN cord-010119-t1x9gknd 4402 28 associated associate VBD cord-010119-t1x9gknd 4402 29 hemodynamic hemodynamic JJ cord-010119-t1x9gknd 4402 30 impact impact NN cord-010119-t1x9gknd 4402 31 could could MD cord-010119-t1x9gknd 4402 32 be be VB cord-010119-t1x9gknd 4402 33 easily easily RB cord-010119-t1x9gknd 4402 34 managed manage VBN cord-010119-t1x9gknd 4402 35 . . . cord-010119-t1x9gknd 4403 1 Both both DT cord-010119-t1x9gknd 4403 2 patients patient NNS cord-010119-t1x9gknd 4403 3 showed show VBD cord-010119-t1x9gknd 4403 4 significant significant JJ cord-010119-t1x9gknd 4403 5 clinical clinical JJ cord-010119-t1x9gknd 4403 6 improvement improvement NN cord-010119-t1x9gknd 4403 7 within within IN cord-010119-t1x9gknd 4403 8 12 12 CD cord-010119-t1x9gknd 4403 9 hours hour NNS cord-010119-t1x9gknd 4403 10 of of IN cord-010119-t1x9gknd 4403 11 the the DT cord-010119-t1x9gknd 4403 12 procedure procedure NN cord-010119-t1x9gknd 4403 13 completion completion NN cord-010119-t1x9gknd 4403 14 . . . cord-010119-t1x9gknd 4404 1 Their -PRON- PRP$ cord-010119-t1x9gknd 4404 2 total total JJ cord-010119-t1x9gknd 4404 3 T4 T4 NNP cord-010119-t1x9gknd 4404 4 , , , cord-010119-t1x9gknd 4404 5 T3 T3 NNP cord-010119-t1x9gknd 4404 6 and and CC cord-010119-t1x9gknd 4404 7 free free JJ cord-010119-t1x9gknd 4404 8 T4 T4 NNP cord-010119-t1x9gknd 4404 9 levels level NNS cord-010119-t1x9gknd 4404 10 trended trend VBD cord-010119-t1x9gknd 4404 11 to to IN cord-010119-t1x9gknd 4404 12 normal normal JJ cord-010119-t1x9gknd 4404 13 or or CC cord-010119-t1x9gknd 4404 14 near near IN cord-010119-t1x9gknd 4404 15 normal normal JJ cord-010119-t1x9gknd 4404 16 range range NN cord-010119-t1x9gknd 4404 17 within within IN cord-010119-t1x9gknd 4404 18 24 24 CD cord-010119-t1x9gknd 4404 19 hours hour NNS cord-010119-t1x9gknd 4404 20 ( ( -LRB- cord-010119-t1x9gknd 4404 21 Table table NN cord-010119-t1x9gknd 4404 22 ) ) -RRB- cord-010119-t1x9gknd 4404 23 . . . cord-010119-t1x9gknd 4405 1 In in IN cord-010119-t1x9gknd 4405 2 addition addition NN cord-010119-t1x9gknd 4405 3 , , , cord-010119-t1x9gknd 4405 4 the the DT cord-010119-t1x9gknd 4405 5 PLEX PLEX NNP cord-010119-t1x9gknd 4405 6 effect effect NN cord-010119-t1x9gknd 4405 7 on on IN cord-010119-t1x9gknd 4405 8 hormone hormone NN cord-010119-t1x9gknd 4405 9 and and CC cord-010119-t1x9gknd 4405 10 the the DT cord-010119-t1x9gknd 4405 11 associated associate VBN cord-010119-t1x9gknd 4405 12 antibody antibody NN cord-010119-t1x9gknd 4405 13 removal removal NN cord-010119-t1x9gknd 4405 14 seemed seem VBD cord-010119-t1x9gknd 4405 15 remained remained JJ cord-010119-t1x9gknd 4405 16 and and CC cord-010119-t1x9gknd 4405 17 no no DT cord-010119-t1x9gknd 4405 18 " " `` cord-010119-t1x9gknd 4405 19 rebound rebound NN cord-010119-t1x9gknd 4405 20 " " '' cord-010119-t1x9gknd 4405 21 phenomenon phenomenon NN cord-010119-t1x9gknd 4405 22 was be VBD cord-010119-t1x9gknd 4405 23 observed observe VBN cord-010119-t1x9gknd 4405 24 in in IN cord-010119-t1x9gknd 4405 25 both both DT cord-010119-t1x9gknd 4405 26 cases case NNS cord-010119-t1x9gknd 4405 27 , , , cord-010119-t1x9gknd 4405 28 making make VBG cord-010119-t1x9gknd 4405 29 repeated repeat VBN cord-010119-t1x9gknd 4405 30 PLEX PLEX NNP cord-010119-t1x9gknd 4405 31 unnecessary unnecessary JJ cord-010119-t1x9gknd 4405 32 . . . cord-010119-t1x9gknd 4406 1 Both both DT cord-010119-t1x9gknd 4406 2 patients patient NNS cord-010119-t1x9gknd 4406 3 had have VBD cord-010119-t1x9gknd 4406 4 total total JJ cord-010119-t1x9gknd 4406 5 thyroidectomy thyroidectomy NN cord-010119-t1x9gknd 4406 6 3 3 CD cord-010119-t1x9gknd 4406 7 - - SYM cord-010119-t1x9gknd 4406 8 4 4 CD cord-010119-t1x9gknd 4406 9 weeks week NNS cord-010119-t1x9gknd 4406 10 after after IN cord-010119-t1x9gknd 4406 11 the the DT cord-010119-t1x9gknd 4406 12 event event NN cord-010119-t1x9gknd 4406 13 with with IN cord-010119-t1x9gknd 4406 14 great great JJ cord-010119-t1x9gknd 4406 15 clinical clinical JJ cord-010119-t1x9gknd 4406 16 outcome outcome NN cord-010119-t1x9gknd 4406 17 . . . cord-010119-t1x9gknd 4407 1 Conclusion conclusion NN cord-010119-t1x9gknd 4407 2 : : : cord-010119-t1x9gknd 4408 1 Our -PRON- PRP$ cord-010119-t1x9gknd 4408 2 cases case NNS cord-010119-t1x9gknd 4408 3 demonstrate demonstrate VBP cord-010119-t1x9gknd 4408 4 that that IN cord-010119-t1x9gknd 4408 5 PLEX PLEX NNP cord-010119-t1x9gknd 4408 6 is be VBZ cord-010119-t1x9gknd 4408 7 a a DT cord-010119-t1x9gknd 4408 8 safe safe JJ cord-010119-t1x9gknd 4408 9 , , , cord-010119-t1x9gknd 4408 10 effective effective JJ cord-010119-t1x9gknd 4408 11 treatment treatment NN cord-010119-t1x9gknd 4408 12 option option NN cord-010119-t1x9gknd 4408 13 in in IN cord-010119-t1x9gknd 4408 14 managing manage VBG cord-010119-t1x9gknd 4408 15 TS TS NNP cord-010119-t1x9gknd 4408 16 patient patient NN cord-010119-t1x9gknd 4408 17 with with IN cord-010119-t1x9gknd 4408 18 severe severe JJ cord-010119-t1x9gknd 4408 19 cardiac cardiac JJ cord-010119-t1x9gknd 4408 20 dysfunction dysfunction NN cord-010119-t1x9gknd 4408 21 . . . cord-010119-t1x9gknd 4409 1 The the DT cord-010119-t1x9gknd 4409 2 procedure procedure NN cord-010119-t1x9gknd 4409 3 can can MD cord-010119-t1x9gknd 4409 4 not not RB cord-010119-t1x9gknd 4409 5 only only RB cord-010119-t1x9gknd 4409 6 lead lead VB cord-010119-t1x9gknd 4409 7 rapid rapid JJ cord-010119-t1x9gknd 4409 8 decrease decrease NN cord-010119-t1x9gknd 4409 9 in in IN cord-010119-t1x9gknd 4409 10 thyroid thyroid JJ cord-010119-t1x9gknd 4409 11 hormone hormone NN cord-010119-t1x9gknd 4409 12 and and CC cord-010119-t1x9gknd 4409 13 its -PRON- PRP$ cord-010119-t1x9gknd 4409 14 associated associate VBN cord-010119-t1x9gknd 4409 15 antibody antibody NN cord-010119-t1x9gknd 4409 16 levels level NNS cord-010119-t1x9gknd 4409 17 , , , cord-010119-t1x9gknd 4409 18 but but CC cord-010119-t1x9gknd 4409 19 also also RB cord-010119-t1x9gknd 4409 20 lessen lessen VB cord-010119-t1x9gknd 4409 21 the the DT cord-010119-t1x9gknd 4409 22 severity severity NN cord-010119-t1x9gknd 4409 23 of of IN cord-010119-t1x9gknd 4409 24 tissue tissue NN cord-010119-t1x9gknd 4409 25 injury injury NN cord-010119-t1x9gknd 4409 26 by by IN cord-010119-t1x9gknd 4409 27 moderating moderate VBG cord-010119-t1x9gknd 4409 28 the the DT cord-010119-t1x9gknd 4409 29 inflammatory inflammatory JJ cord-010119-t1x9gknd 4409 30 process process NN cord-010119-t1x9gknd 4409 31 and and CC cord-010119-t1x9gknd 4409 32 correcting correct VBG cord-010119-t1x9gknd 4409 33 complications complication NNS cord-010119-t1x9gknd 4409 34 . . . cord-010119-t1x9gknd 4410 1 Extracorporeal Extracorporeal NNP cord-010119-t1x9gknd 4410 2 Photopheresis Photopheresis NNP cord-010119-t1x9gknd 4410 3 in in IN cord-010119-t1x9gknd 4410 4 S S NNP cord-010119-t1x9gknd 4410 5 ezary ezary NNP cord-010119-t1x9gknd 4410 6 Syndrome Syndrome NNP cord-010119-t1x9gknd 4410 7 Treatment Treatment NNP cord-010119-t1x9gknd 4410 8 : : : cord-010119-t1x9gknd 4411 1 Hospital hospital NN cord-010119-t1x9gknd 4411 2 - - HYPH cord-010119-t1x9gknd 4411 3 Based Based NNP cord-010119-t1x9gknd 4411 4 Blood Blood NNP cord-010119-t1x9gknd 4411 5 Bank Bank NNP cord-010119-t1x9gknd 4411 6 Experience experience NN cord-010119-t1x9gknd 4412 1 Sandra Sandra NNP cord-010119-t1x9gknd 4412 2 Ortega Ortega NNP cord-010119-t1x9gknd 4412 3 S S NNP cord-010119-t1x9gknd 4413 1 anchez anchez NNP cord-010119-t1x9gknd 4413 2 * * NFP cord-010119-t1x9gknd 4413 3 1 1 CD cord-010119-t1x9gknd 4413 4 , , , cord-010119-t1x9gknd 4413 5 Laura Laura NNP cord-010119-t1x9gknd 4413 6 Martínez Martínez NNP cord-010119-t1x9gknd 4413 7 Molina Molina NNP cord-010119-t1x9gknd 4413 8 2 2 CD cord-010119-t1x9gknd 4413 9 , , , cord-010119-t1x9gknd 4413 10 Cristina Cristina NNP cord-010119-t1x9gknd 4413 11 Muniesa Muniesa NNP cord-010119-t1x9gknd 4413 12 Montserrat Montserrat NNP cord-010119-t1x9gknd 4413 13 2 2 CD cord-010119-t1x9gknd 4413 14 , , , cord-010119-t1x9gknd 4413 15 Octavio Octavio NNP cord-010119-t1x9gknd 4413 16 Servitje Servitje NNP cord-010119-t1x9gknd 4413 17 Bedate Bedate NNP cord-010119-t1x9gknd 4413 18 2 2 CD cord-010119-t1x9gknd 4413 19 , , , cord-010119-t1x9gknd 4413 20 Silvia Silvia NNP cord-010119-t1x9gknd 4413 21 Cosano Cosano NNP cord-010119-t1x9gknd 4413 22 Navarro Navarro NNP cord-010119-t1x9gknd 4413 23 1 1 CD cord-010119-t1x9gknd 4413 24 and and CC cord-010119-t1x9gknd 4413 25 Maria Maria NNP cord-010119-t1x9gknd 4413 26 Isabel Isabel NNP cord-010119-t1x9gknd 4413 27 Gonz Gonz NNP cord-010119-t1x9gknd 4413 28 alez alez NN cord-010119-t1x9gknd 4413 29 Medina Medina NNP cord-010119-t1x9gknd 4413 30 1 1 CD cord-010119-t1x9gknd 4413 31 . . . cord-010119-t1x9gknd 4414 1 1 1 LS cord-010119-t1x9gknd 4415 1 Banc Banc NNP cord-010119-t1x9gknd 4415 2 de de IN cord-010119-t1x9gknd 4415 3 Sang Sang NNP cord-010119-t1x9gknd 4415 4 i i NNP cord-010119-t1x9gknd 4415 5 Teixits Teixits NNP cord-010119-t1x9gknd 4415 6 , , , cord-010119-t1x9gknd 4415 7 2 2 CD cord-010119-t1x9gknd 4415 8 Dermatology Dermatology NNP cord-010119-t1x9gknd 4415 9 service service NN cord-010119-t1x9gknd 4415 10 . . . cord-010119-t1x9gknd 4416 1 Background Background NNP cord-010119-t1x9gknd 4416 2 / / SYM cord-010119-t1x9gknd 4416 3 Case Case NNP cord-010119-t1x9gknd 4416 4 Studies Studies NNPS cord-010119-t1x9gknd 4416 5 : : : cord-010119-t1x9gknd 4417 1 Extracorporeal extracorporeal JJ cord-010119-t1x9gknd 4417 2 photopheresis photopheresis NN cord-010119-t1x9gknd 4417 3 ( ( -LRB- cord-010119-t1x9gknd 4417 4 ECP ECP NNP cord-010119-t1x9gknd 4417 5 ) ) -RRB- cord-010119-t1x9gknd 4417 6 is be VBZ cord-010119-t1x9gknd 4417 7 an an DT cord-010119-t1x9gknd 4417 8 immunomodulatory immunomodulatory JJ cord-010119-t1x9gknd 4417 9 therapy therapy NN cord-010119-t1x9gknd 4417 10 widely widely RB cord-010119-t1x9gknd 4417 11 used use VBN cord-010119-t1x9gknd 4417 12 since since IN cord-010119-t1x9gknd 4417 13 30 30 CD cord-010119-t1x9gknd 4417 14 years year NNS cord-010119-t1x9gknd 4417 15 in in IN cord-010119-t1x9gknd 4417 16 cutaneous cutaneous JJ cord-010119-t1x9gknd 4417 17 T T NNP cord-010119-t1x9gknd 4417 18 cell cell NN cord-010119-t1x9gknd 4417 19 lymphoma lymphoma NN cord-010119-t1x9gknd 4417 20 , , , cord-010119-t1x9gknd 4417 21 several several JJ cord-010119-t1x9gknd 4417 22 autoimmune autoimmune JJ cord-010119-t1x9gknd 4417 23 diseases disease NNS cord-010119-t1x9gknd 4417 24 and and CC cord-010119-t1x9gknd 4417 25 organ organ NN cord-010119-t1x9gknd 4417 26 transplant transplant NN cord-010119-t1x9gknd 4417 27 rejection rejection NN cord-010119-t1x9gknd 4417 28 , , , cord-010119-t1x9gknd 4417 29 and and CC cord-010119-t1x9gknd 4417 30 in in IN cord-010119-t1x9gknd 4417 31 the the DT cord-010119-t1x9gknd 4417 32 last last JJ cord-010119-t1x9gknd 4417 33 20 20 CD cord-010119-t1x9gknd 4417 34 years year NNS cord-010119-t1x9gknd 4417 35 , , , cord-010119-t1x9gknd 4417 36 also also RB cord-010119-t1x9gknd 4417 37 used use VBN cord-010119-t1x9gknd 4417 38 in in IN cord-010119-t1x9gknd 4417 39 graft graft NN cord-010119-t1x9gknd 4417 40 versus versus IN cord-010119-t1x9gknd 4417 41 host host NN cord-010119-t1x9gknd 4417 42 disease disease NN cord-010119-t1x9gknd 4417 43 treatment treatment NN cord-010119-t1x9gknd 4417 44 . . . cord-010119-t1x9gknd 4418 1 The the DT cord-010119-t1x9gknd 4418 2 use use NN cord-010119-t1x9gknd 4418 3 of of IN cord-010119-t1x9gknd 4418 4 ECP ECP NNP cord-010119-t1x9gknd 4418 5 in in IN cord-010119-t1x9gknd 4418 6 cutaneous cutaneous JJ cord-010119-t1x9gknd 4418 7 T T NNP cord-010119-t1x9gknd 4418 8 cell cell NN cord-010119-t1x9gknd 4418 9 lymphoma lymphoma NN cord-010119-t1x9gknd 4418 10 ( ( -LRB- cord-010119-t1x9gknd 4418 11 CTCL CTCL NNP cord-010119-t1x9gknd 4418 12 ) ) -RRB- cord-010119-t1x9gknd 4418 13 , , , cord-010119-t1x9gknd 4418 14 mycosis mycosis NNP cord-010119-t1x9gknd 4418 15 fungoides fungoides NNP cord-010119-t1x9gknd 4418 16 ( ( -LRB- cord-010119-t1x9gknd 4418 17 MF MF NNP cord-010119-t1x9gknd 4418 18 ) ) -RRB- cord-010119-t1x9gknd 4418 19 and and CC cord-010119-t1x9gknd 4418 20 S S NNP cord-010119-t1x9gknd 4418 21 ezary ezary NNP cord-010119-t1x9gknd 4418 22 Syndrome Syndrome NNP cord-010119-t1x9gknd 4418 23 ( ( -LRB- cord-010119-t1x9gknd 4418 24 SS SS NNP cord-010119-t1x9gknd 4418 25 ) ) -RRB- cord-010119-t1x9gknd 4418 26 in in IN cord-010119-t1x9gknd 4418 27 their -PRON- PRP$ cord-010119-t1x9gknd 4418 28 erytrodermic erytrodermic JJ cord-010119-t1x9gknd 4418 29 form form NN cord-010119-t1x9gknd 4418 30 are be VBP cord-010119-t1x9gknd 4418 31 recently recently RB cord-010119-t1x9gknd 4418 32 categorized categorize VBN cord-010119-t1x9gknd 4418 33 by by IN cord-010119-t1x9gknd 4418 34 the the DT cord-010119-t1x9gknd 4418 35 American American NNP cord-010119-t1x9gknd 4418 36 Society Society NNP cord-010119-t1x9gknd 4418 37 for for IN cord-010119-t1x9gknd 4418 38 A a DT cord-010119-t1x9gknd 4418 39 pheresis pheresis NN cord-010119-t1x9gknd 4418 40 ( ( -LRB- cord-010119-t1x9gknd 4418 41 ASFA ASFA NNP cord-010119-t1x9gknd 4418 42 ) ) -RRB- cord-010119-t1x9gknd 4418 43 2016 2016 CD cord-010119-t1x9gknd 4418 44 , , , cord-010119-t1x9gknd 4418 45 as as IN cord-010119-t1x9gknd 4418 46 first first JJ cord-010119-t1x9gknd 4418 47 line line NN cord-010119-t1x9gknd 4418 48 treatment treatment NN cord-010119-t1x9gknd 4418 49 alone alone RB cord-010119-t1x9gknd 4418 50 or or CC cord-010119-t1x9gknd 4418 51 in in IN cord-010119-t1x9gknd 4418 52 combination combination NN cord-010119-t1x9gknd 4418 53 with with IN cord-010119-t1x9gknd 4418 54 other other JJ cord-010119-t1x9gknd 4418 55 therapies therapy NNS cord-010119-t1x9gknd 4418 56 , , , cord-010119-t1x9gknd 4418 57 with with IN cord-010119-t1x9gknd 4418 58 a a DT cord-010119-t1x9gknd 4418 59 strong strong JJ cord-010119-t1x9gknd 4418 60 recommendation recommendation NN cord-010119-t1x9gknd 4418 61 : : : cord-010119-t1x9gknd 4418 62 grade grade NN cord-010119-t1x9gknd 4418 63 IB IB NNP cord-010119-t1x9gknd 4418 64 , , , cord-010119-t1x9gknd 4418 65 category category NN cord-010119-t1x9gknd 4418 66 1 1 CD cord-010119-t1x9gknd 4418 67 . . . cord-010119-t1x9gknd 4419 1 Since since IN cord-010119-t1x9gknd 4419 2 MF MF NNP cord-010119-t1x9gknd 4419 3 and and CC cord-010119-t1x9gknd 4419 4 SS SS NNP cord-010119-t1x9gknd 4419 5 are be VBP cord-010119-t1x9gknd 4419 6 incurable incurable JJ cord-010119-t1x9gknd 4419 7 diseases disease NNS cord-010119-t1x9gknd 4419 8 current current JJ cord-010119-t1x9gknd 4419 9 therapies therapy NNS cord-010119-t1x9gknd 4419 10 are be VBP cord-010119-t1x9gknd 4419 11 focus focus JJ cord-010119-t1x9gknd 4419 12 in in IN cord-010119-t1x9gknd 4419 13 controlling control VBG cord-010119-t1x9gknd 4419 14 skin skin NN cord-010119-t1x9gknd 4419 15 symptoms symptom NNS cord-010119-t1x9gknd 4419 16 and and CC cord-010119-t1x9gknd 4419 17 minimizing minimize VBG cord-010119-t1x9gknd 4419 18 immunosuppression immunosuppression NN cord-010119-t1x9gknd 4419 19 . . . cord-010119-t1x9gknd 4420 1 The the DT cord-010119-t1x9gknd 4420 2 objective objective NN cord-010119-t1x9gknd 4420 3 of of IN cord-010119-t1x9gknd 4420 4 this this DT cord-010119-t1x9gknd 4420 5 observational observational JJ cord-010119-t1x9gknd 4420 6 study study NN cord-010119-t1x9gknd 4420 7 is be VBZ cord-010119-t1x9gknd 4420 8 to to TO cord-010119-t1x9gknd 4420 9 assess assess VB cord-010119-t1x9gknd 4420 10 outcomes outcome NNS cord-010119-t1x9gknd 4420 11 of of IN cord-010119-t1x9gknd 4420 12 10 10 CD cord-010119-t1x9gknd 4420 13 patients patient NNS cord-010119-t1x9gknd 4420 14 diagnosed diagnose VBN cord-010119-t1x9gknd 4420 15 with with IN cord-010119-t1x9gknd 4420 16 SS SS NNP cord-010119-t1x9gknd 4420 17 and and CC cord-010119-t1x9gknd 4420 18 compare compare VB cord-010119-t1x9gknd 4420 19 them -PRON- PRP cord-010119-t1x9gknd 4420 20 in in IN cord-010119-t1x9gknd 4420 21 their -PRON- PRP$ cord-010119-t1x9gknd 4420 22 first first JJ cord-010119-t1x9gknd 4420 23 evaluation evaluation NN cord-010119-t1x9gknd 4420 24 once once IN cord-010119-t1x9gknd 4420 25 the the DT cord-010119-t1x9gknd 4420 26 20 20 CD cord-010119-t1x9gknd 4420 27 th th XX cord-010119-t1x9gknd 4420 28 procedure procedure NN cord-010119-t1x9gknd 4420 29 is be VBZ cord-010119-t1x9gknd 4420 30 been be VBN cord-010119-t1x9gknd 4420 31 performed perform VBN cord-010119-t1x9gknd 4420 32 . . . cord-010119-t1x9gknd 4421 1 Study Study NNP cord-010119-t1x9gknd 4421 2 Design Design NNP cord-010119-t1x9gknd 4421 3 / / SYM cord-010119-t1x9gknd 4421 4 Method method NN cord-010119-t1x9gknd 4421 5 : : : cord-010119-t1x9gknd 4422 1 ECP ECP NNP cord-010119-t1x9gknd 4422 2 is be VBZ cord-010119-t1x9gknd 4422 3 a a DT cord-010119-t1x9gknd 4422 4 leukapheresis leukapheresis NN cord-010119-t1x9gknd 4422 5 - - HYPH cord-010119-t1x9gknd 4422 6 based base VBN cord-010119-t1x9gknd 4422 7 therapy therapy NN cord-010119-t1x9gknd 4422 8 , , , cord-010119-t1x9gknd 4422 9 ex ex NN cord-010119-t1x9gknd 4422 10 vivo vivo NN cord-010119-t1x9gknd 4422 11 exposition exposition NN cord-010119-t1x9gknd 4422 12 to to IN cord-010119-t1x9gknd 4422 13 a a DT cord-010119-t1x9gknd 4422 14 photosensitizer photosensitizer NNP cord-010119-t1x9gknd 4422 15 drug drug NN cord-010119-t1x9gknd 4422 16 ( ( -LRB- cord-010119-t1x9gknd 4422 17 8-methoxypsoralen 8-methoxypsoralen CD cord-010119-t1x9gknd 4422 18 , , , cord-010119-t1x9gknd 4422 19 8-MOP 8-mop CD cord-010119-t1x9gknd 4422 20 ) ) -RRB- cord-010119-t1x9gknd 4422 21 and and CC cord-010119-t1x9gknd 4422 22 UVA UVA NNP cord-010119-t1x9gknd 4422 23 light light NN cord-010119-t1x9gknd 4422 24 , , , cord-010119-t1x9gknd 4422 25 and and CC cord-010119-t1x9gknd 4422 26 subsequent subsequent JJ cord-010119-t1x9gknd 4422 27 reinfusion reinfusion NN cord-010119-t1x9gknd 4422 28 of of IN cord-010119-t1x9gknd 4422 29 the the DT cord-010119-t1x9gknd 4422 30 treated treat VBN cord-010119-t1x9gknd 4422 31 cells cell NNS cord-010119-t1x9gknd 4422 32 which which WDT cord-010119-t1x9gknd 4422 33 are be VBP cord-010119-t1x9gknd 4422 34 now now RB cord-010119-t1x9gknd 4422 35 induced induce VBN cord-010119-t1x9gknd 4422 36 to to IN cord-010119-t1x9gknd 4422 37 apoptosis apoptosis NN cord-010119-t1x9gknd 4422 38 . . . cord-010119-t1x9gknd 4423 1 Volume volume NN cord-010119-t1x9gknd 4423 2 treated treat VBN cord-010119-t1x9gknd 4423 3 varies vary VBZ cord-010119-t1x9gknd 4423 4 from from IN cord-010119-t1x9gknd 4423 5 1.5 1.5 CD cord-010119-t1x9gknd 4423 6 to to TO cord-010119-t1x9gknd 4423 7 2 2 CD cord-010119-t1x9gknd 4423 8 total total JJ cord-010119-t1x9gknd 4423 9 body body NN cord-010119-t1x9gknd 4423 10 volume volume NN cord-010119-t1x9gknd 4423 11 ( ( -LRB- cord-010119-t1x9gknd 4423 12 TBV TBV NNP cord-010119-t1x9gknd 4423 13 ) ) -RRB- cord-010119-t1x9gknd 4423 14 and and CC cord-010119-t1x9gknd 4423 15 the the DT cord-010119-t1x9gknd 4423 16 schedule schedule NN cord-010119-t1x9gknd 4423 17 for for IN cord-010119-t1x9gknd 4423 18 SS SS NNP cord-010119-t1x9gknd 4423 19 disease disease NN cord-010119-t1x9gknd 4423 20 is be VBZ cord-010119-t1x9gknd 4423 21 one one CD cord-010119-t1x9gknd 4423 22 cycle cycle NN cord-010119-t1x9gknd 4423 23 ( ( -LRB- cord-010119-t1x9gknd 4423 24 two two CD cord-010119-t1x9gknd 4423 25 daily daily JJ cord-010119-t1x9gknd 4423 26 ECP ECP NNP cord-010119-t1x9gknd 4423 27 procedures procedure NNS cord-010119-t1x9gknd 4423 28 ) ) -RRB- cord-010119-t1x9gknd 4423 29 twice twice RB cord-010119-t1x9gknd 4423 30 per per IN cord-010119-t1x9gknd 4423 31 month month NN cord-010119-t1x9gknd 4423 32 . . . cord-010119-t1x9gknd 4424 1 The the DT cord-010119-t1x9gknd 4424 2 venous venous JJ cord-010119-t1x9gknd 4424 3 access access NN cord-010119-t1x9gknd 4424 4 was be VBD cord-010119-t1x9gknd 4424 5 peripheral peripheral JJ cord-010119-t1x9gknd 4424 6 in in IN cord-010119-t1x9gknd 4424 7 all all DT cord-010119-t1x9gknd 4424 8 cases case NNS cord-010119-t1x9gknd 4424 9 except except IN cord-010119-t1x9gknd 4424 10 in in IN cord-010119-t1x9gknd 4424 11 2 2 CD cord-010119-t1x9gknd 4424 12 where where WRB cord-010119-t1x9gknd 4424 13 central central JJ cord-010119-t1x9gknd 4424 14 catheter catheter NN cord-010119-t1x9gknd 4424 15 was be VBD cord-010119-t1x9gknd 4424 16 needed need VBN cord-010119-t1x9gknd 4424 17 . . . cord-010119-t1x9gknd 4425 1 The the DT cord-010119-t1x9gknd 4425 2 procedures procedure NNS cord-010119-t1x9gknd 4425 3 were be VBD cord-010119-t1x9gknd 4425 4 performed perform VBN cord-010119-t1x9gknd 4425 5 with with IN cord-010119-t1x9gknd 4425 6 OPTIA OPTIA NNP cord-010119-t1x9gknd 4425 7 or or CC cord-010119-t1x9gknd 4425 8 Amicus Amicus NNP cord-010119-t1x9gknd 4425 9 devices device NNS cord-010119-t1x9gknd 4425 10 for for IN cord-010119-t1x9gknd 4425 11 the the DT cord-010119-t1x9gknd 4425 12 aphaeresis aphaeresis NNP cord-010119-t1x9gknd 4425 13 and and CC cord-010119-t1x9gknd 4425 14 external external JJ cord-010119-t1x9gknd 4425 15 UVA UVA NNP cord-010119-t1x9gknd 4425 16 irradiation irradiation NN cord-010119-t1x9gknd 4425 17 for for IN cord-010119-t1x9gknd 4425 18 off off IN cord-010119-t1x9gknd 4425 19 - - HYPH cord-010119-t1x9gknd 4425 20 line line NN cord-010119-t1x9gknd 4425 21 system system NN cord-010119-t1x9gknd 4425 22 ( ( -LRB- cord-010119-t1x9gknd 4425 23 in in IN cord-010119-t1x9gknd 4425 24 7/10 7/10 CD cord-010119-t1x9gknd 4425 25 patients patient NNS cord-010119-t1x9gknd 4425 26 ) ) -RRB- cord-010119-t1x9gknd 4425 27 and and CC cord-010119-t1x9gknd 4425 28 with with IN cord-010119-t1x9gknd 4425 29 online online JJ cord-010119-t1x9gknd 4425 30 system system NN cord-010119-t1x9gknd 4425 31 ( ( -LRB- cord-010119-t1x9gknd 4425 32 Therakos Therakos NNP cord-010119-t1x9gknd 4425 33 ) ) -RRB- cord-010119-t1x9gknd 4425 34 just just RB cord-010119-t1x9gknd 4425 35 in in IN cord-010119-t1x9gknd 4425 36 3 3 CD cord-010119-t1x9gknd 4425 37 . . . cord-010119-t1x9gknd 4426 1 Main main JJ cord-010119-t1x9gknd 4426 2 parameters parameter NNS cord-010119-t1x9gknd 4426 3 for for IN cord-010119-t1x9gknd 4426 4 evaluation evaluation NN cord-010119-t1x9gknd 4426 5 were be VBD cord-010119-t1x9gknd 4426 6 cutaneous cutaneous JJ cord-010119-t1x9gknd 4426 7 response response NN cord-010119-t1x9gknd 4426 8 rate rate NN cord-010119-t1x9gknd 4426 9 , , , cord-010119-t1x9gknd 4426 10 number number NN cord-010119-t1x9gknd 4426 11 of of IN cord-010119-t1x9gknd 4426 12 s s NNP cord-010119-t1x9gknd 4426 13 ezary ezary NNP cord-010119-t1x9gknd 4426 14 cells cell NNS cord-010119-t1x9gknd 4426 15 , , , cord-010119-t1x9gknd 4426 16 previous previous JJ cord-010119-t1x9gknd 4426 17 treatments treatment NNS cord-010119-t1x9gknd 4426 18 , , , cord-010119-t1x9gknd 4426 19 duration duration NN cord-010119-t1x9gknd 4426 20 of of IN cord-010119-t1x9gknd 4426 21 the the DT cord-010119-t1x9gknd 4426 22 response response NN cord-010119-t1x9gknd 4426 23 and and CC cord-010119-t1x9gknd 4426 24 possible possible JJ cord-010119-t1x9gknd 4426 25 complications complication NNS cord-010119-t1x9gknd 4426 26 during during IN cord-010119-t1x9gknd 4426 27 ECP ECP NNP cord-010119-t1x9gknd 4426 28 treatment treatment NN cord-010119-t1x9gknd 4426 29 . . . cord-010119-t1x9gknd 4427 1 Results/ Results/ . cord-010119-t1x9gknd 4428 1 Finding finding NN cord-010119-t1x9gknd 4428 2 : : : cord-010119-t1x9gknd 4429 1 Global global JJ cord-010119-t1x9gknd 4429 2 response response NN cord-010119-t1x9gknd 4429 3 rate rate NN cord-010119-t1x9gknd 4429 4 is be VBZ cord-010119-t1x9gknd 4429 5 77'7 77'7 CD cord-010119-t1x9gknd 4429 6 % % NN cord-010119-t1x9gknd 4429 7 ( ( -LRB- cord-010119-t1x9gknd 4429 8 partial partial JJ cord-010119-t1x9gknd 4429 9 remission remission NN cord-010119-t1x9gknd 4429 10 66.6 66.6 CD cord-010119-t1x9gknd 4429 11 % % NN cord-010119-t1x9gknd 4429 12 and and CC cord-010119-t1x9gknd 4429 13 complete complete VB cord-010119-t1x9gknd 4429 14 remission remission NN cord-010119-t1x9gknd 4429 15 11.1 11.1 CD cord-010119-t1x9gknd 4429 16 % % NN cord-010119-t1x9gknd 4429 17 with with IN cord-010119-t1x9gknd 4429 18 maintained maintain VBN cord-010119-t1x9gknd 4429 19 response response NN cord-010119-t1x9gknd 4429 20 ) ) -RRB- cord-010119-t1x9gknd 4429 21 . . . cord-010119-t1x9gknd 4430 1 No no DT cord-010119-t1x9gknd 4430 2 severe severe JJ cord-010119-t1x9gknd 4430 3 side side NN cord-010119-t1x9gknd 4430 4 effects effect NNS cord-010119-t1x9gknd 4430 5 related relate VBN cord-010119-t1x9gknd 4430 6 with with IN cord-010119-t1x9gknd 4430 7 the the DT cord-010119-t1x9gknd 4430 8 procedure procedure NN cord-010119-t1x9gknd 4430 9 were be VBD cord-010119-t1x9gknd 4430 10 found find VBN cord-010119-t1x9gknd 4430 11 . . . cord-010119-t1x9gknd 4431 1 The the DT cord-010119-t1x9gknd 4431 2 patient patient NN cord-010119-t1x9gknd 4431 3 outcomes outcome NNS cord-010119-t1x9gknd 4431 4 analyzed analyze VBN cord-010119-t1x9gknd 4431 5 are be VBP cord-010119-t1x9gknd 4431 6 similar similar JJ cord-010119-t1x9gknd 4431 7 to to IN cord-010119-t1x9gknd 4431 8 results result NNS cord-010119-t1x9gknd 4431 9 in in IN cord-010119-t1x9gknd 4431 10 published publish VBN cord-010119-t1x9gknd 4431 11 literature literature NN cord-010119-t1x9gknd 4431 12 . . . cord-010119-t1x9gknd 4432 1 Conclusion conclusion NN cord-010119-t1x9gknd 4432 2 : : : cord-010119-t1x9gknd 4432 3 Cases case NNS cord-010119-t1x9gknd 4432 4 treated treat VBN cord-010119-t1x9gknd 4432 5 in in IN cord-010119-t1x9gknd 4432 6 our -PRON- PRP$ cord-010119-t1x9gknd 4432 7 hospital hospital NN cord-010119-t1x9gknd 4432 8 confirm confirm VB cord-010119-t1x9gknd 4432 9 the the DT cord-010119-t1x9gknd 4432 10 efficacy efficacy NN cord-010119-t1x9gknd 4432 11 of of IN cord-010119-t1x9gknd 4432 12 ECP ECP NNP cord-010119-t1x9gknd 4432 13 in in IN cord-010119-t1x9gknd 4432 14 SS SS NNP cord-010119-t1x9gknd 4432 15 treatment treatment NN cord-010119-t1x9gknd 4432 16 , , , cord-010119-t1x9gknd 4432 17 with with IN cord-010119-t1x9gknd 4432 18 a a DT cord-010119-t1x9gknd 4432 19 good good JJ cord-010119-t1x9gknd 4432 20 safety safety NN cord-010119-t1x9gknd 4432 21 profile profile NN cord-010119-t1x9gknd 4432 22 . . . cord-010119-t1x9gknd 4433 1 Another another DT cord-010119-t1x9gknd 4433 2 great great JJ cord-010119-t1x9gknd 4433 3 advantage advantage NN cord-010119-t1x9gknd 4433 4 of of IN cord-010119-t1x9gknd 4433 5 ECP ECP NNP cord-010119-t1x9gknd 4433 6 is be VBZ cord-010119-t1x9gknd 4433 7 the the DT cord-010119-t1x9gknd 4433 8 relative relative JJ cord-010119-t1x9gknd 4433 9 lack lack NN cord-010119-t1x9gknd 4433 10 of of IN cord-010119-t1x9gknd 4433 11 immune immune JJ cord-010119-t1x9gknd 4433 12 suppression suppression NN cord-010119-t1x9gknd 4433 13 . . . cord-010119-t1x9gknd 4434 1 Many many JJ cord-010119-t1x9gknd 4434 2 questions question NNS cord-010119-t1x9gknd 4434 3 remain remain VBP cord-010119-t1x9gknd 4434 4 still still RB cord-010119-t1x9gknd 4434 5 unanswered unanswered JJ cord-010119-t1x9gknd 4434 6 about about IN cord-010119-t1x9gknd 4434 7 ECP ECP NNP cord-010119-t1x9gknd 4434 8 : : : cord-010119-t1x9gknd 4435 1 which which WDT cord-010119-t1x9gknd 4435 2 schedule schedule NN cord-010119-t1x9gknd 4435 3 is be VBZ cord-010119-t1x9gknd 4435 4 the the DT cord-010119-t1x9gknd 4435 5 most most RBS cord-010119-t1x9gknd 4435 6 suitable suitable JJ cord-010119-t1x9gknd 4435 7 one one CD cord-010119-t1x9gknd 4435 8 , , , cord-010119-t1x9gknd 4435 9 how how WRB cord-010119-t1x9gknd 4435 10 we -PRON- PRP cord-010119-t1x9gknd 4435 11 must must MD cord-010119-t1x9gknd 4435 12 continue continue VB cord-010119-t1x9gknd 4435 13 or or CC cord-010119-t1x9gknd 4435 14 stop stop VB cord-010119-t1x9gknd 4435 15 when when WRB cord-010119-t1x9gknd 4435 16 partial partial JJ cord-010119-t1x9gknd 4435 17 or or CC cord-010119-t1x9gknd 4435 18 complete complete JJ cord-010119-t1x9gknd 4435 19 remission remission NN cord-010119-t1x9gknd 4435 20 is be VBZ cord-010119-t1x9gknd 4435 21 achieved achieve VBN cord-010119-t1x9gknd 4435 22 ; ; : cord-010119-t1x9gknd 4435 23 and and CC cord-010119-t1x9gknd 4435 24 the the DT cord-010119-t1x9gknd 4435 25 number number NN cord-010119-t1x9gknd 4435 26 of of IN cord-010119-t1x9gknd 4435 27 leukocytes leukocyte NNS cord-010119-t1x9gknd 4435 28 to to TO cord-010119-t1x9gknd 4435 29 be be VB cord-010119-t1x9gknd 4435 30 treated treat VBN cord-010119-t1x9gknd 4435 31 , , , cord-010119-t1x9gknd 4435 32 as as IN cord-010119-t1x9gknd 4435 33 techniques technique NNS cord-010119-t1x9gknd 4435 34 as as IN cord-010119-t1x9gknd 4435 35 mini mini NN cord-010119-t1x9gknd 4435 36 - - NN cord-010119-t1x9gknd 4435 37 photopheresis photopheresis NN cord-010119-t1x9gknd 4435 38 are be VBP cord-010119-t1x9gknd 4435 39 also also RB cord-010119-t1x9gknd 4435 40 getting get VBG cord-010119-t1x9gknd 4435 41 good good JJ cord-010119-t1x9gknd 4435 42 results result NNS cord-010119-t1x9gknd 4435 43 . . . cord-010119-t1x9gknd 4436 1 All all PDT cord-010119-t1x9gknd 4436 2 these these DT cord-010119-t1x9gknd 4436 3 questions question NNS cord-010119-t1x9gknd 4436 4 and and CC cord-010119-t1x9gknd 4436 5 more more RBR cord-010119-t1x9gknd 4436 6 make make VB cord-010119-t1x9gknd 4436 7 prospective prospective JJ cord-010119-t1x9gknd 4436 8 studies study NNS cord-010119-t1x9gknd 4436 9 necessary necessary JJ cord-010119-t1x9gknd 4436 10 to to TO cord-010119-t1x9gknd 4436 11 be be VB cord-010119-t1x9gknd 4436 12 performed perform VBN cord-010119-t1x9gknd 4436 13 . . . cord-010119-t1x9gknd 4437 1 : : : cord-010119-t1x9gknd 4437 2 3835 3835 CD cord-010119-t1x9gknd 4437 3 U U NNP cord-010119-t1x9gknd 4437 4 / / SYM cord-010119-t1x9gknd 4437 5 L l NN cord-010119-t1x9gknd 4437 6 ) ) -RRB- cord-010119-t1x9gknd 4437 7 requiring require VBG cord-010119-t1x9gknd 4437 8 transfusions transfusion NNS cord-010119-t1x9gknd 4437 9 , , , cord-010119-t1x9gknd 4437 10 mild mild JJ cord-010119-t1x9gknd 4437 11 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 4437 12 ( ( -LRB- cord-010119-t1x9gknd 4438 1 144 144 CD cord-010119-t1x9gknd 4438 2 x x SYM cord-010119-t1x9gknd 4438 3 10 10 CD cord-010119-t1x9gknd 4438 4 9 9 CD cord-010119-t1x9gknd 4438 5 /L /l CD cord-010119-t1x9gknd 4438 6 ) ) -RRB- cord-010119-t1x9gknd 4438 7 , , , cord-010119-t1x9gknd 4438 8 acute acute JJ cord-010119-t1x9gknd 4438 9 kidney kidney NN cord-010119-t1x9gknd 4438 10 injury injury NN cord-010119-t1x9gknd 4439 1 ( ( -LRB- cord-010119-t1x9gknd 4439 2 BUN bun NN cord-010119-t1x9gknd 4439 3 175 175 CD cord-010119-t1x9gknd 4439 4 mg mg NNP cord-010119-t1x9gknd 4439 5 / / SYM cord-010119-t1x9gknd 4439 6 dL dl NN cord-010119-t1x9gknd 4439 7 , , , cord-010119-t1x9gknd 4439 8 creatinine creatinine NN cord-010119-t1x9gknd 4439 9 2.51 2.51 CD cord-010119-t1x9gknd 4439 10 mg mg NNP cord-010119-t1x9gknd 4439 11 / / SYM cord-010119-t1x9gknd 4439 12 dL dl NN cord-010119-t1x9gknd 4439 13 ) ) -RRB- cord-010119-t1x9gknd 4439 14 . . . cord-010119-t1x9gknd 4440 1 By by IN cord-010119-t1x9gknd 4440 2 the the DT cord-010119-t1x9gknd 4440 3 third third JJ cord-010119-t1x9gknd 4440 4 hospitalization hospitalization NN cord-010119-t1x9gknd 4440 5 day day NN cord-010119-t1x9gknd 4440 6 Hgb Hgb NNP cord-010119-t1x9gknd 4440 7 improved improve VBD cord-010119-t1x9gknd 4440 8 to to IN cord-010119-t1x9gknd 4440 9 10 10 CD cord-010119-t1x9gknd 4440 10 g g NN cord-010119-t1x9gknd 4440 11 / / SYM cord-010119-t1x9gknd 4440 12 dL dl NN cord-010119-t1x9gknd 4440 13 , , , cord-010119-t1x9gknd 4440 14 however however RB cord-010119-t1x9gknd 4440 15 with with IN cord-010119-t1x9gknd 4440 16 worsening worsen VBG cord-010119-t1x9gknd 4440 17 thrombocytopenia thrombocytopenia NNS cord-010119-t1x9gknd 4440 18 ( ( -LRB- cord-010119-t1x9gknd 4440 19 16 16 CD cord-010119-t1x9gknd 4440 20 x x SYM cord-010119-t1x9gknd 4440 21 10 10 CD cord-010119-t1x9gknd 4440 22 9 9 CD cord-010119-t1x9gknd 4440 23 /L /L . cord-010119-t1x9gknd 4440 24 ) ) -RRB- cord-010119-t1x9gknd 4440 25 that that WDT cord-010119-t1x9gknd 4440 26 led lead VBD cord-010119-t1x9gknd 4440 27 to to IN cord-010119-t1x9gknd 4440 28 clinical clinical JJ cord-010119-t1x9gknd 4440 29 concern concern NN cord-010119-t1x9gknd 4440 30 for for IN cord-010119-t1x9gknd 4440 31 TTP TTP NNP cord-010119-t1x9gknd 4440 32 . . . cord-010119-t1x9gknd 4441 1 Peripheral peripheral JJ cord-010119-t1x9gknd 4441 2 smear smear NN cord-010119-t1x9gknd 4441 3 showed show VBD cord-010119-t1x9gknd 4441 4 many many JJ cord-010119-t1x9gknd 4441 5 red red JJ cord-010119-t1x9gknd 4441 6 cell cell NN cord-010119-t1x9gknd 4441 7 fragments fragment NNS cord-010119-t1x9gknd 4441 8 . . . cord-010119-t1x9gknd 4442 1 Patient Patient NNP cord-010119-t1x9gknd 4442 2 was be VBD cord-010119-t1x9gknd 4442 3 transfused transfuse VBN cord-010119-t1x9gknd 4442 4 with with IN cord-010119-t1x9gknd 4442 5 platelets platelet NNS cord-010119-t1x9gknd 4442 6 day day NN cord-010119-t1x9gknd 4442 7 prior prior RB cord-010119-t1x9gknd 4442 8 to to IN cord-010119-t1x9gknd 4442 9 first first JJ cord-010119-t1x9gknd 4442 10 TPE TPE NNP cord-010119-t1x9gknd 4442 11 . . . cord-010119-t1x9gknd 4443 1 Immature immature JJ cord-010119-t1x9gknd 4443 2 platelet platelet NN cord-010119-t1x9gknd 4443 3 fraction fraction NN cord-010119-t1x9gknd 4443 4 ( ( -LRB- cord-010119-t1x9gknd 4443 5 % % NN cord-010119-t1x9gknd 4443 6 -IPF -ipf CD cord-010119-t1x9gknd 4443 7 ) ) -RRB- cord-010119-t1x9gknd 4443 8 and and CC cord-010119-t1x9gknd 4443 9 A A NNP cord-010119-t1x9gknd 4443 10 - - HYPH cord-010119-t1x9gknd 4443 11 IPC IPC NNP cord-010119-t1x9gknd 4443 12 ( ( -LRB- cord-010119-t1x9gknd 4443 13 % % NN cord-010119-t1x9gknd 4443 14 -IPF -ipf SYM cord-010119-t1x9gknd 4443 15 x x SYM cord-010119-t1x9gknd 4443 16 platelet platelet NN cord-010119-t1x9gknd 4443 17 count count NN cord-010119-t1x9gknd 4443 18 ) ) -RRB- cord-010119-t1x9gknd 4443 19 were be VBD cord-010119-t1x9gknd 4443 20 obtained obtain VBN cord-010119-t1x9gknd 4443 21 with with IN cord-010119-t1x9gknd 4443 22 daily daily JJ cord-010119-t1x9gknd 4443 23 pre pre JJ cord-010119-t1x9gknd 4443 24 - - NNP cord-010119-t1x9gknd 4443 25 TPE TPE NNP cord-010119-t1x9gknd 4443 26 CBC CBC NNP cord-010119-t1x9gknd 4443 27 . . . cord-010119-t1x9gknd 4444 1 A a LS cord-010119-t1x9gknd 4444 2 - - HYPH cord-010119-t1x9gknd 4444 3 IPC IPC NNP cord-010119-t1x9gknd 4444 4 ratio ratio NN cord-010119-t1x9gknd 4444 5 was be VBD cord-010119-t1x9gknd 4444 6 calculated calculate VBN cord-010119-t1x9gknd 4444 7 from from IN cord-010119-t1x9gknd 4444 8 baseline baseline NN cord-010119-t1x9gknd 4444 9 . . . cord-010119-t1x9gknd 4445 1 Results/ Results/ . cord-010119-t1x9gknd 4446 1 Finding finding NN cord-010119-t1x9gknd 4446 2 : : : cord-010119-t1x9gknd 4447 1 Four four CD cord-010119-t1x9gknd 4447 2 TPE tpe NN cord-010119-t1x9gknd 4447 3 in in IN cord-010119-t1x9gknd 4447 4 five five CD cord-010119-t1x9gknd 4447 5 days day NNS cord-010119-t1x9gknd 4447 6 were be VBD cord-010119-t1x9gknd 4447 7 performed perform VBN cord-010119-t1x9gknd 4447 8 ( ( -LRB- cord-010119-t1x9gknd 4447 9 hospital hospital NN cord-010119-t1x9gknd 4447 10 days day NNS cord-010119-t1x9gknd 4447 11 6 6 CD cord-010119-t1x9gknd 4447 12 - - SYM cord-010119-t1x9gknd 4447 13 10 10 CD cord-010119-t1x9gknd 4447 14 ) ) -RRB- cord-010119-t1x9gknd 4447 15 . . . cord-010119-t1x9gknd 4448 1 Platelet platelet NN cord-010119-t1x9gknd 4448 2 count count NN cord-010119-t1x9gknd 4448 3 and and CC cord-010119-t1x9gknd 4448 4 A A NNP cord-010119-t1x9gknd 4448 5 - - HYPH cord-010119-t1x9gknd 4448 6 IPC IPC NNP cord-010119-t1x9gknd 4448 7 improved improve VBD cord-010119-t1x9gknd 4448 8 to to IN cord-010119-t1x9gknd 4448 9 52 52 CD cord-010119-t1x9gknd 4448 10 x x SYM cord-010119-t1x9gknd 4448 11 10 10 CD cord-010119-t1x9gknd 4448 12 9 9 CD cord-010119-t1x9gknd 4448 13 /L /L . cord-010119-t1x9gknd 4448 14 and and CC cord-010119-t1x9gknd 4448 15 6.6 6.6 CD cord-010119-t1x9gknd 4448 16 x x SYM cord-010119-t1x9gknd 4448 17 10 10 CD cord-010119-t1x9gknd 4448 18 9 9 CD cord-010119-t1x9gknd 4448 19 /L /L . cord-010119-t1x9gknd 4448 20 respectively respectively RB cord-010119-t1x9gknd 4448 21 just just RB cord-010119-t1x9gknd 4448 22 prior prior RB cord-010119-t1x9gknd 4448 23 to to IN cord-010119-t1x9gknd 4448 24 first first JJ cord-010119-t1x9gknd 4448 25 TPE TPE NNP cord-010119-t1x9gknd 4448 26 . . . cord-010119-t1x9gknd 4449 1 Response response NN cord-010119-t1x9gknd 4449 2 to to IN cord-010119-t1x9gknd 4449 3 four four CD cord-010119-t1x9gknd 4449 4 TPE TPE NNP cord-010119-t1x9gknd 4449 5 led lead VBD cord-010119-t1x9gknd 4449 6 to to IN cord-010119-t1x9gknd 4449 7 a a DT cord-010119-t1x9gknd 4449 8 decrease decrease NN cord-010119-t1x9gknd 4449 9 in in IN cord-010119-t1x9gknd 4449 10 both both DT cord-010119-t1x9gknd 4449 11 platelet platelet NN cord-010119-t1x9gknd 4449 12 count count NN cord-010119-t1x9gknd 4449 13 ( ( -LRB- cord-010119-t1x9gknd 4449 14 30 30 CD cord-010119-t1x9gknd 4449 15 x x SYM cord-010119-t1x9gknd 4449 16 10 10 CD cord-010119-t1x9gknd 4449 17 9 9 CD cord-010119-t1x9gknd 4449 18 /L /l CD cord-010119-t1x9gknd 4449 19 ) ) -RRB- cord-010119-t1x9gknd 4449 20 and and CC cord-010119-t1x9gknd 4449 21 A A NNP cord-010119-t1x9gknd 4449 22 - - HYPH cord-010119-t1x9gknd 4449 23 IPC IPC NNP cord-010119-t1x9gknd 4449 24 1.98 1.98 CD cord-010119-t1x9gknd 4449 25 x x SYM cord-010119-t1x9gknd 4449 26 10 10 CD cord-010119-t1x9gknd 4449 27 9 9 CD cord-010119-t1x9gknd 4450 1 /L. /L. . cord-010119-t1x9gknd 4451 1 These these DT cord-010119-t1x9gknd 4451 2 dynamics dynamic NNS cord-010119-t1x9gknd 4451 3 did do VBD cord-010119-t1x9gknd 4451 4 not not RB cord-010119-t1x9gknd 4451 5 resemble resemble VB cord-010119-t1x9gknd 4451 6 those those DT cord-010119-t1x9gknd 4451 7 which which WDT cord-010119-t1x9gknd 4451 8 had have VBD cord-010119-t1x9gknd 4451 9 been be VBN cord-010119-t1x9gknd 4451 10 described describe VBN cord-010119-t1x9gknd 4451 11 for for IN cord-010119-t1x9gknd 4451 12 TTP TTP NNP cord-010119-t1x9gknd 4451 13 patients patient NNS cord-010119-t1x9gknd 4451 14 with with IN cord-010119-t1x9gknd 4451 15 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4451 16 deficiency deficiency NN cord-010119-t1x9gknd 4451 17 . . . cord-010119-t1x9gknd 4452 1 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4452 2 obtained obtain VBN cord-010119-t1x9gknd 4452 3 prior prior RB cord-010119-t1x9gknd 4452 4 to to IN cord-010119-t1x9gknd 4452 5 TPE TPE NNP cord-010119-t1x9gknd 4452 6 initiation initiation NN cord-010119-t1x9gknd 4452 7 was be VBD cord-010119-t1x9gknd 4452 8 resulted result VBN cord-010119-t1x9gknd 4452 9 at at IN cord-010119-t1x9gknd 4452 10 this this DT cord-010119-t1x9gknd 4452 11 time time NN cord-010119-t1x9gknd 4452 12 and and CC cord-010119-t1x9gknd 4452 13 was be VBD cord-010119-t1x9gknd 4452 14 67 67 CD cord-010119-t1x9gknd 4452 15 % % NN cord-010119-t1x9gknd 4452 16 . . . cord-010119-t1x9gknd 4453 1 No no DT cord-010119-t1x9gknd 4453 2 causative causative JJ cord-010119-t1x9gknd 4453 3 organism organism NN cord-010119-t1x9gknd 4453 4 or or CC cord-010119-t1x9gknd 4453 5 toxin toxin NN cord-010119-t1x9gknd 4453 6 was be VBD cord-010119-t1x9gknd 4453 7 identified identify VBN cord-010119-t1x9gknd 4453 8 after after IN cord-010119-t1x9gknd 4453 9 urine urine NN cord-010119-t1x9gknd 4453 10 , , , cord-010119-t1x9gknd 4453 11 blood blood NN cord-010119-t1x9gknd 4453 12 , , , cord-010119-t1x9gknd 4453 13 and and CC cord-010119-t1x9gknd 4453 14 stool stool NN cord-010119-t1x9gknd 4453 15 examination examination NN cord-010119-t1x9gknd 4453 16 and and CC cord-010119-t1x9gknd 4453 17 culture culture NN cord-010119-t1x9gknd 4453 18 . . . cord-010119-t1x9gknd 4454 1 Based base VBN cord-010119-t1x9gknd 4454 2 on on IN cord-010119-t1x9gknd 4454 3 these these DT cord-010119-t1x9gknd 4454 4 results result NNS cord-010119-t1x9gknd 4454 5 , , , cord-010119-t1x9gknd 4454 6 TPE TPE NNP cord-010119-t1x9gknd 4454 7 was be VBD cord-010119-t1x9gknd 4454 8 discontinued discontinue VBN cord-010119-t1x9gknd 4454 9 which which WDT cord-010119-t1x9gknd 4454 10 led lead VBD cord-010119-t1x9gknd 4454 11 to to IN cord-010119-t1x9gknd 4454 12 an an DT cord-010119-t1x9gknd 4454 13 immediate immediate JJ cord-010119-t1x9gknd 4454 14 increase increase NN cord-010119-t1x9gknd 4454 15 in in IN cord-010119-t1x9gknd 4454 16 A A NNP cord-010119-t1x9gknd 4454 17 - - HYPH cord-010119-t1x9gknd 4454 18 IPC IPC NNP cord-010119-t1x9gknd 4454 19 ( ( -LRB- cord-010119-t1x9gknd 4454 20 2.64 2.64 CD cord-010119-t1x9gknd 4454 21 x x SYM cord-010119-t1x9gknd 4454 22 10 10 CD cord-010119-t1x9gknd 4454 23 9 9 CD cord-010119-t1x9gknd 4454 24 /L /L . cord-010119-t1x9gknd 4454 25 ) ) -RRB- cord-010119-t1x9gknd 4454 26 that that WDT cord-010119-t1x9gknd 4454 27 preceded precede VBD cord-010119-t1x9gknd 4454 28 platelet platelet NN cord-010119-t1x9gknd 4454 29 count count NN cord-010119-t1x9gknd 4454 30 increase increase NN cord-010119-t1x9gknd 4454 31 to to IN cord-010119-t1x9gknd 4454 32 80 80 CD cord-010119-t1x9gknd 4454 33 x x SYM cord-010119-t1x9gknd 4454 34 10 10 CD cord-010119-t1x9gknd 4454 35 9 9 CD cord-010119-t1x9gknd 4454 36 /L /L , cord-010119-t1x9gknd 4454 37 three three CD cord-010119-t1x9gknd 4454 38 days day NNS cord-010119-t1x9gknd 4454 39 later later RB cord-010119-t1x9gknd 4454 40 when when WRB cord-010119-t1x9gknd 4454 41 patient patient NN cord-010119-t1x9gknd 4454 42 was be VBD cord-010119-t1x9gknd 4454 43 discharged discharge VBN cord-010119-t1x9gknd 4454 44 . . . cord-010119-t1x9gknd 4455 1 Other other JJ cord-010119-t1x9gknd 4455 2 laboratory laboratory NN cord-010119-t1x9gknd 4455 3 values value NNS cord-010119-t1x9gknd 4455 4 at at IN cord-010119-t1x9gknd 4455 5 this this DT cord-010119-t1x9gknd 4455 6 time time NN cord-010119-t1x9gknd 4455 7 were be VBD cord-010119-t1x9gknd 4455 8 LDH LDH NNP cord-010119-t1x9gknd 4455 9 of of IN cord-010119-t1x9gknd 4455 10 635 635 CD cord-010119-t1x9gknd 4455 11 U U NNP cord-010119-t1x9gknd 4455 12 / / SYM cord-010119-t1x9gknd 4455 13 L L NNP cord-010119-t1x9gknd 4455 14 , , , cord-010119-t1x9gknd 4455 15 Hgb Hgb NNP cord-010119-t1x9gknd 4455 16 : : : cord-010119-t1x9gknd 4455 17 11.2 11.2 CD cord-010119-t1x9gknd 4455 18 g g NN cord-010119-t1x9gknd 4455 19 / / SYM cord-010119-t1x9gknd 4455 20 dL dl NN cord-010119-t1x9gknd 4455 21 in in IN cord-010119-t1x9gknd 4455 22 the the DT cord-010119-t1x9gknd 4455 23 setting setting NN cord-010119-t1x9gknd 4455 24 of of IN cord-010119-t1x9gknd 4455 25 recovery recovery NN cord-010119-t1x9gknd 4455 26 of of IN cord-010119-t1x9gknd 4455 27 renal renal JJ cord-010119-t1x9gknd 4455 28 function function NN cord-010119-t1x9gknd 4455 29 . . . cord-010119-t1x9gknd 4456 1 Conclusion conclusion NN cord-010119-t1x9gknd 4456 2 : : : cord-010119-t1x9gknd 4457 1 Timely timely JJ cord-010119-t1x9gknd 4457 2 diagnosis diagnosis NN cord-010119-t1x9gknd 4457 3 of of IN cord-010119-t1x9gknd 4457 4 TTP TTP NNP cord-010119-t1x9gknd 4457 5 is be VBZ cord-010119-t1x9gknd 4457 6 essential essential JJ cord-010119-t1x9gknd 4457 7 to to TO cord-010119-t1x9gknd 4457 8 start start VB cord-010119-t1x9gknd 4457 9 of of IN cord-010119-t1x9gknd 4457 10 TPE TPE NNP cord-010119-t1x9gknd 4457 11 . . . cord-010119-t1x9gknd 4458 1 A a LS cord-010119-t1x9gknd 4458 2 - - HYPH cord-010119-t1x9gknd 4458 3 IPC IPC NNP cord-010119-t1x9gknd 4458 4 dynamics dynamic NNS cord-010119-t1x9gknd 4458 5 differ differ VBP cord-010119-t1x9gknd 4458 6 in in IN cord-010119-t1x9gknd 4458 7 TTP ttp NN cord-010119-t1x9gknd 4458 8 compared compare VBN cord-010119-t1x9gknd 4458 9 to to IN cord-010119-t1x9gknd 4458 10 other other JJ cord-010119-t1x9gknd 4458 11 thrombotic thrombotic JJ cord-010119-t1x9gknd 4458 12 microangiopathies microangiopathie NNS cord-010119-t1x9gknd 4458 13 . . . cord-010119-t1x9gknd 4459 1 In in IN cord-010119-t1x9gknd 4459 2 our -PRON- PRP$ cord-010119-t1x9gknd 4459 3 patient patient NN cord-010119-t1x9gknd 4459 4 A A NNP cord-010119-t1x9gknd 4459 5 - - HYPH cord-010119-t1x9gknd 4459 6 IPC IPC NNP cord-010119-t1x9gknd 4459 7 failed fail VBD cord-010119-t1x9gknd 4459 8 to to TO cord-010119-t1x9gknd 4459 9 improve improve VB cord-010119-t1x9gknd 4459 10 despite despite IN cord-010119-t1x9gknd 4459 11 TPE TPE NNP cord-010119-t1x9gknd 4459 12 and and CC cord-010119-t1x9gknd 4459 13 improved improve VBD cord-010119-t1x9gknd 4459 14 once once IN cord-010119-t1x9gknd 4459 15 procedures procedure NNS cord-010119-t1x9gknd 4459 16 were be VBD cord-010119-t1x9gknd 4459 17 discontinued discontinue VBN cord-010119-t1x9gknd 4459 18 and and CC cord-010119-t1x9gknd 4459 19 were be VBD cord-010119-t1x9gknd 4459 20 followed follow VBN cord-010119-t1x9gknd 4459 21 by by IN cord-010119-t1x9gknd 4459 22 increases increase NNS cord-010119-t1x9gknd 4459 23 in in IN cord-010119-t1x9gknd 4459 24 platelet platelet NN cord-010119-t1x9gknd 4459 25 counts count VBZ cord-010119-t1x9gknd 4459 26 three three CD cord-010119-t1x9gknd 4459 27 days day NNS cord-010119-t1x9gknd 4459 28 later later RB cord-010119-t1x9gknd 4459 29 . . . cord-010119-t1x9gknd 4460 1 When when WRB cord-010119-t1x9gknd 4460 2 TTP TTP NNP cord-010119-t1x9gknd 4460 3 is be VBZ cord-010119-t1x9gknd 4460 4 not not RB cord-010119-t1x9gknd 4460 5 the the DT cord-010119-t1x9gknd 4460 6 causative causative JJ cord-010119-t1x9gknd 4460 7 etiology etiology NN cord-010119-t1x9gknd 4460 8 , , , cord-010119-t1x9gknd 4460 9 A A NNP cord-010119-t1x9gknd 4460 10 - - HYPH cord-010119-t1x9gknd 4460 11 IPC IPC NNP cord-010119-t1x9gknd 4460 12 can can MD cord-010119-t1x9gknd 4460 13 help help VB cord-010119-t1x9gknd 4460 14 adjust adjust VB cord-010119-t1x9gknd 4460 15 therapy therapy NN cord-010119-t1x9gknd 4460 16 and and CC cord-010119-t1x9gknd 4460 17 lead lead VB cord-010119-t1x9gknd 4460 18 to to IN cord-010119-t1x9gknd 4460 19 clinical clinical JJ cord-010119-t1x9gknd 4460 20 improvement improvement NN cord-010119-t1x9gknd 4460 21 . . . cord-010119-t1x9gknd 4461 1 Further further JJ cord-010119-t1x9gknd 4461 2 research research NN cord-010119-t1x9gknd 4461 3 is be VBZ cord-010119-t1x9gknd 4461 4 needed need VBN cord-010119-t1x9gknd 4461 5 to to TO cord-010119-t1x9gknd 4461 6 characterize characterize VB cord-010119-t1x9gknd 4461 7 immature immature JJ cord-010119-t1x9gknd 4461 8 platelet platelet NN cord-010119-t1x9gknd 4461 9 dynamics dynamic NNS cord-010119-t1x9gknd 4461 10 in in IN cord-010119-t1x9gknd 4461 11 non non JJ cord-010119-t1x9gknd 4461 12 - - JJ cord-010119-t1x9gknd 4461 13 TTP ttp JJ cord-010119-t1x9gknd 4461 14 microangiopathies microangiopathie NNS cord-010119-t1x9gknd 4461 15 . . . cord-010119-t1x9gknd 4462 1 Infection infection NN cord-010119-t1x9gknd 4462 2 and and CC cord-010119-t1x9gknd 4462 3 Its -PRON- PRP$ cord-010119-t1x9gknd 4462 4 Role role NN cord-010119-t1x9gknd 4462 5 in in IN cord-010119-t1x9gknd 4462 6 the the DT cord-010119-t1x9gknd 4462 7 Clinical Clinical NNP cord-010119-t1x9gknd 4462 8 Course course NN cord-010119-t1x9gknd 4462 9 of of IN cord-010119-t1x9gknd 4463 1 Idiopathic Idiopathic NNP cord-010119-t1x9gknd 4463 2 Thrombotic Thrombotic NNP cord-010119-t1x9gknd 4463 3 Thrombocytopenic Thrombocytopenic NNP cord-010119-t1x9gknd 4463 4 Purpura purpura NN cord-010119-t1x9gknd 4463 5 Associated Associated NNP cord-010119-t1x9gknd 4463 6 with with IN cord-010119-t1x9gknd 4463 7 Severe severe JJ cord-010119-t1x9gknd 4463 8 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4463 9 Deficiency Deficiency NNP cord-010119-t1x9gknd 4463 10 Eiman Eiman NNP cord-010119-t1x9gknd 4463 11 Hussein Hussein NNP cord-010119-t1x9gknd 4464 1 * * NFP cord-010119-t1x9gknd 4464 2 1 1 CD cord-010119-t1x9gknd 4464 3 and and CC cord-010119-t1x9gknd 4464 4 Jun Jun NNP cord-010119-t1x9gknd 4464 5 Teruya Teruya NNP cord-010119-t1x9gknd 4464 6 2 2 CD cord-010119-t1x9gknd 4464 7 . . . cord-010119-t1x9gknd 4465 1 1 1 LS cord-010119-t1x9gknd 4465 2 Department Department NNP cord-010119-t1x9gknd 4465 3 of of IN cord-010119-t1x9gknd 4465 4 Clinical Clinical NNP cord-010119-t1x9gknd 4465 5 Pathology Pathology NNP cord-010119-t1x9gknd 4465 6 , , , cord-010119-t1x9gknd 4465 7 Cairo Cairo NNP cord-010119-t1x9gknd 4465 8 University University NNP cord-010119-t1x9gknd 4465 9 , , , cord-010119-t1x9gknd 4465 10 2 2 CD cord-010119-t1x9gknd 4465 11 Texas Texas NNP cord-010119-t1x9gknd 4465 12 Children Children NNP cord-010119-t1x9gknd 4465 13 's 's POS cord-010119-t1x9gknd 4465 14 Hospital Hospital NNP cord-010119-t1x9gknd 4465 15 Background Background NNP cord-010119-t1x9gknd 4465 16 / / SYM cord-010119-t1x9gknd 4465 17 Case Case NNP cord-010119-t1x9gknd 4465 18 Studies Studies NNPS cord-010119-t1x9gknd 4465 19 : : : cord-010119-t1x9gknd 4465 20 TTP TTP NNP cord-010119-t1x9gknd 4465 21 is be VBZ cord-010119-t1x9gknd 4465 22 a a DT cord-010119-t1x9gknd 4465 23 life life NN cord-010119-t1x9gknd 4465 24 threatening threaten VBG cord-010119-t1x9gknd 4465 25 disease disease NN cord-010119-t1x9gknd 4465 26 , , , cord-010119-t1x9gknd 4465 27 defined define VBN cord-010119-t1x9gknd 4465 28 by by IN cord-010119-t1x9gknd 4465 29 microangiopathic microangiopathic JJ cord-010119-t1x9gknd 4465 30 hemolytic hemolytic JJ cord-010119-t1x9gknd 4465 31 anemia anemia NN cord-010119-t1x9gknd 4465 32 , , , cord-010119-t1x9gknd 4465 33 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 4465 34 and and CC cord-010119-t1x9gknd 4465 35 severely severely RB cord-010119-t1x9gknd 4465 36 deficient deficient JJ cord-010119-t1x9gknd 4466 1 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4466 2 . . . cord-010119-t1x9gknd 4467 1 Since since IN cord-010119-t1x9gknd 4467 2 the the DT cord-010119-t1x9gknd 4467 3 introduction introduction NN cord-010119-t1x9gknd 4467 4 of of IN cord-010119-t1x9gknd 4467 5 therapeutic therapeutic JJ cord-010119-t1x9gknd 4467 6 plasma plasma NN cord-010119-t1x9gknd 4467 7 exchange exchange NN cord-010119-t1x9gknd 4467 8 ( ( -LRB- cord-010119-t1x9gknd 4467 9 TPE TPE NNP cord-010119-t1x9gknd 4467 10 ) ) -RRB- cord-010119-t1x9gknd 4467 11 as as IN cord-010119-t1x9gknd 4467 12 a a DT cord-010119-t1x9gknd 4467 13 treatment treatment NN cord-010119-t1x9gknd 4467 14 modality modality NN cord-010119-t1x9gknd 4467 15 for for IN cord-010119-t1x9gknd 4467 16 TTP TTP NNP cord-010119-t1x9gknd 4467 17 , , , cord-010119-t1x9gknd 4467 18 its -PRON- PRP$ cord-010119-t1x9gknd 4467 19 prognosis prognosis NN cord-010119-t1x9gknd 4467 20 has have VBZ cord-010119-t1x9gknd 4467 21 improved improve VBN cord-010119-t1x9gknd 4467 22 dramatically dramatically RB cord-010119-t1x9gknd 4467 23 . . . cord-010119-t1x9gknd 4468 1 Nonetheless nonetheless RB cord-010119-t1x9gknd 4468 2 , , , cord-010119-t1x9gknd 4468 3 some some DT cord-010119-t1x9gknd 4468 4 patients patient NNS cord-010119-t1x9gknd 4468 5 may may MD cord-010119-t1x9gknd 4468 6 develop develop VB cord-010119-t1x9gknd 4468 7 relapse relapse NN cord-010119-t1x9gknd 4468 8 or or CC cord-010119-t1x9gknd 4468 9 refractoriness refractoriness NN cord-010119-t1x9gknd 4468 10 , , , cord-010119-t1x9gknd 4468 11 with with IN cord-010119-t1x9gknd 4468 12 potentially potentially RB cord-010119-t1x9gknd 4468 13 fatal fatal JJ cord-010119-t1x9gknd 4468 14 outcomes outcome NNS cord-010119-t1x9gknd 4468 15 . . . cord-010119-t1x9gknd 4469 1 Despite despite IN cord-010119-t1x9gknd 4469 2 the the DT cord-010119-t1x9gknd 4469 3 notable notable JJ cord-010119-t1x9gknd 4469 4 progress progress NN cord-010119-t1x9gknd 4469 5 that that WDT cord-010119-t1x9gknd 4469 6 has have VBZ cord-010119-t1x9gknd 4469 7 been be VBN cord-010119-t1x9gknd 4469 8 made make VBN cord-010119-t1x9gknd 4469 9 with with IN cord-010119-t1x9gknd 4469 10 studies study NNS cord-010119-t1x9gknd 4469 11 that that WDT cord-010119-t1x9gknd 4469 12 emphasized emphasize VBD cord-010119-t1x9gknd 4469 13 the the DT cord-010119-t1x9gknd 4469 14 pivotal pivotal JJ cord-010119-t1x9gknd 4469 15 role role NN cord-010119-t1x9gknd 4469 16 of of IN cord-010119-t1x9gknd 4469 17 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4469 18 , , , cord-010119-t1x9gknd 4469 19 the the DT cord-010119-t1x9gknd 4469 20 epidemiology epidemiology NN cord-010119-t1x9gknd 4469 21 of of IN cord-010119-t1x9gknd 4469 22 TTP TTP NNP cord-010119-t1x9gknd 4469 23 remains remain VBZ cord-010119-t1x9gknd 4469 24 uncertain uncertain JJ cord-010119-t1x9gknd 4469 25 . . . cord-010119-t1x9gknd 4470 1 Previous previous JJ cord-010119-t1x9gknd 4470 2 studies study NNS cord-010119-t1x9gknd 4470 3 have have VBP cord-010119-t1x9gknd 4470 4 suggested suggest VBN cord-010119-t1x9gknd 4470 5 that that IN cord-010119-t1x9gknd 4470 6 many many JJ cord-010119-t1x9gknd 4470 7 factors factor NNS cord-010119-t1x9gknd 4470 8 appear appear VBP cord-010119-t1x9gknd 4470 9 to to TO cord-010119-t1x9gknd 4470 10 influence influence VB cord-010119-t1x9gknd 4470 11 its -PRON- PRP$ cord-010119-t1x9gknd 4470 12 pathogenesis pathogenesis NN cord-010119-t1x9gknd 4470 13 . . . cord-010119-t1x9gknd 4471 1 Some some DT cord-010119-t1x9gknd 4471 2 studies study NNS cord-010119-t1x9gknd 4471 3 point point VBP cord-010119-t1x9gknd 4471 4 toward toward IN cord-010119-t1x9gknd 4471 5 infection infection NN cord-010119-t1x9gknd 4471 6 as as IN cord-010119-t1x9gknd 4471 7 a a DT cord-010119-t1x9gknd 4471 8 possible possible JJ cord-010119-t1x9gknd 4471 9 trigger trigger NN cord-010119-t1x9gknd 4471 10 which which WDT cord-010119-t1x9gknd 4471 11 may may MD cord-010119-t1x9gknd 4471 12 contribute contribute VB cord-010119-t1x9gknd 4471 13 to to IN cord-010119-t1x9gknd 4471 14 the the DT cord-010119-t1x9gknd 4471 15 development development NN cord-010119-t1x9gknd 4471 16 and and CC cord-010119-t1x9gknd 4471 17 can can MD cord-010119-t1x9gknd 4471 18 ultimately ultimately RB cord-010119-t1x9gknd 4471 19 influence influence VB cord-010119-t1x9gknd 4471 20 its -PRON- PRP$ cord-010119-t1x9gknd 4471 21 clinical clinical JJ cord-010119-t1x9gknd 4471 22 course course NN cord-010119-t1x9gknd 4471 23 . . . cord-010119-t1x9gknd 4472 1 One one CD cord-010119-t1x9gknd 4472 2 of of IN cord-010119-t1x9gknd 4472 3 the the DT cord-010119-t1x9gknd 4472 4 theories theory NNS cord-010119-t1x9gknd 4472 5 to to TO cord-010119-t1x9gknd 4472 6 explain explain VB cord-010119-t1x9gknd 4472 7 this this DT cord-010119-t1x9gknd 4472 8 association association NN cord-010119-t1x9gknd 4472 9 is be VBZ cord-010119-t1x9gknd 4472 10 the the DT cord-010119-t1x9gknd 4472 11 possible possible JJ cord-010119-t1x9gknd 4472 12 cross cross NN cord-010119-t1x9gknd 4472 13 reactivity reactivity NN cord-010119-t1x9gknd 4472 14 between between IN cord-010119-t1x9gknd 4472 15 antibodies antibody NNS cord-010119-t1x9gknd 4472 16 targeting target VBG cord-010119-t1x9gknd 4472 17 infectious infectious JJ cord-010119-t1x9gknd 4472 18 pathogens pathogen NNS cord-010119-t1x9gknd 4472 19 and and CC cord-010119-t1x9gknd 4472 20 those those DT cord-010119-t1x9gknd 4472 21 directed direct VBN cord-010119-t1x9gknd 4472 22 against against IN cord-010119-t1x9gknd 4472 23 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4472 24 . . . cord-010119-t1x9gknd 4473 1 The the DT cord-010119-t1x9gknd 4473 2 aim aim NN cord-010119-t1x9gknd 4473 3 of of IN cord-010119-t1x9gknd 4473 4 this this DT cord-010119-t1x9gknd 4473 5 study study NN cord-010119-t1x9gknd 4473 6 was be VBD cord-010119-t1x9gknd 4473 7 to to TO cord-010119-t1x9gknd 4473 8 prospectively prospectively RB cord-010119-t1x9gknd 4473 9 examine examine VB cord-010119-t1x9gknd 4473 10 the the DT cord-010119-t1x9gknd 4473 11 potential potential JJ cord-010119-t1x9gknd 4473 12 association association NN cord-010119-t1x9gknd 4473 13 between between IN cord-010119-t1x9gknd 4473 14 infection infection NN cord-010119-t1x9gknd 4473 15 and and CC cord-010119-t1x9gknd 4473 16 the the DT cord-010119-t1x9gknd 4473 17 clinical clinical JJ cord-010119-t1x9gknd 4473 18 outcome outcome NN cord-010119-t1x9gknd 4473 19 in in IN cord-010119-t1x9gknd 4473 20 a a DT cord-010119-t1x9gknd 4473 21 cohort cohort NN cord-010119-t1x9gknd 4473 22 of of IN cord-010119-t1x9gknd 4473 23 patients patient NNS cord-010119-t1x9gknd 4473 24 with with IN cord-010119-t1x9gknd 4473 25 idiopathic idiopathic JJ cord-010119-t1x9gknd 4473 26 TTP ttp NN cord-010119-t1x9gknd 4473 27 . . . cord-010119-t1x9gknd 4474 1 Study Study NNP cord-010119-t1x9gknd 4474 2 Design Design NNP cord-010119-t1x9gknd 4474 3 / / SYM cord-010119-t1x9gknd 4474 4 Method method NN cord-010119-t1x9gknd 4474 5 : : : cord-010119-t1x9gknd 4475 1 Patients patient NNS cord-010119-t1x9gknd 4475 2 with with IN cord-010119-t1x9gknd 4475 3 idiopathic idiopathic JJ cord-010119-t1x9gknd 4475 4 TTP TTP NNP cord-010119-t1x9gknd 4475 5 who who WP cord-010119-t1x9gknd 4475 6 underwent undergo VBD cord-010119-t1x9gknd 4475 7 TPE TPE NNP cord-010119-t1x9gknd 4475 8 from from IN cord-010119-t1x9gknd 4475 9 January January NNP cord-010119-t1x9gknd 4475 10 2008 2008 CD cord-010119-t1x9gknd 4475 11 through through IN cord-010119-t1x9gknd 4475 12 March March NNP cord-010119-t1x9gknd 4475 13 2017 2017 CD cord-010119-t1x9gknd 4475 14 were be VBD cord-010119-t1x9gknd 4475 15 studied study VBN cord-010119-t1x9gknd 4475 16 . . . cord-010119-t1x9gknd 4476 1 Sessions session NNS cord-010119-t1x9gknd 4476 2 were be VBD cord-010119-t1x9gknd 4476 3 performed perform VBN cord-010119-t1x9gknd 4476 4 daily daily RB cord-010119-t1x9gknd 4476 5 until until IN cord-010119-t1x9gknd 4476 6 platelets platelet NNS cord-010119-t1x9gknd 4476 7 and and CC cord-010119-t1x9gknd 4476 8 reticulocytes reticulocyte NNS cord-010119-t1x9gknd 4476 9 had have VBD cord-010119-t1x9gknd 4476 10 been be VBN cord-010119-t1x9gknd 4476 11 normal normal JJ cord-010119-t1x9gknd 4476 12 , , , cord-010119-t1x9gknd 4476 13 then then RB cord-010119-t1x9gknd 4476 14 sessions session NNS cord-010119-t1x9gknd 4476 15 were be VBD cord-010119-t1x9gknd 4476 16 gradually gradually RB cord-010119-t1x9gknd 4476 17 tapered taper VBN cord-010119-t1x9gknd 4476 18 . . . cord-010119-t1x9gknd 4477 1 We -PRON- PRP cord-010119-t1x9gknd 4477 2 only only RB cord-010119-t1x9gknd 4477 3 included include VBD cord-010119-t1x9gknd 4477 4 patients patient NNS cord-010119-t1x9gknd 4477 5 with with IN cord-010119-t1x9gknd 4477 6 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4477 7 activity activity NN cord-010119-t1x9gknd 4477 8 of of IN cord-010119-t1x9gknd 4477 9 less less JJR cord-010119-t1x9gknd 4477 10 than than IN cord-010119-t1x9gknd 4477 11 10 10 CD cord-010119-t1x9gknd 4477 12 % % NN cord-010119-t1x9gknd 4477 13 . . . cord-010119-t1x9gknd 4478 1 Data datum NNS cord-010119-t1x9gknd 4478 2 on on IN cord-010119-t1x9gknd 4478 3 infections infection NNS cord-010119-t1x9gknd 4478 4 that that WDT cord-010119-t1x9gknd 4478 5 occurred occur VBD cord-010119-t1x9gknd 4478 6 at at IN cord-010119-t1x9gknd 4478 7 or or CC cord-010119-t1x9gknd 4478 8 within within IN cord-010119-t1x9gknd 4478 9 a a DT cord-010119-t1x9gknd 4478 10 week week NN cord-010119-t1x9gknd 4478 11 prior prior RB cord-010119-t1x9gknd 4478 12 to to IN cord-010119-t1x9gknd 4478 13 the the DT cord-010119-t1x9gknd 4478 14 development development NN cord-010119-t1x9gknd 4478 15 of of IN cord-010119-t1x9gknd 4478 16 TTP TTP NNP cord-010119-t1x9gknd 4478 17 were be VBD cord-010119-t1x9gknd 4478 18 analyzed analyze VBN cord-010119-t1x9gknd 4478 19 . . . cord-010119-t1x9gknd 4479 1 Results/ Results/ . cord-010119-t1x9gknd 4480 1 Finding finding NN cord-010119-t1x9gknd 4480 2 : : : cord-010119-t1x9gknd 4481 1 Thirty thirty CD cord-010119-t1x9gknd 4481 2 - - HYPH cord-010119-t1x9gknd 4481 3 two two CD cord-010119-t1x9gknd 4481 4 patients patient NNS cord-010119-t1x9gknd 4481 5 were be VBD cord-010119-t1x9gknd 4481 6 categorized categorize VBN cord-010119-t1x9gknd 4481 7 as as IN cord-010119-t1x9gknd 4481 8 idiopathic idiopathic JJ cord-010119-t1x9gknd 4481 9 TTP ttp NN cord-010119-t1x9gknd 4481 10 with with IN cord-010119-t1x9gknd 4481 11 severe severe JJ cord-010119-t1x9gknd 4481 12 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 4481 13 deficiency deficiency NN cord-010119-t1x9gknd 4481 14 . . . cord-010119-t1x9gknd 4482 1 Eight eight CD cord-010119-t1x9gknd 4482 2 patients patient NNS cord-010119-t1x9gknd 4482 3 ( ( -LRB- cord-010119-t1x9gknd 4482 4 25 25 CD cord-010119-t1x9gknd 4482 5 % % NN cord-010119-t1x9gknd 4482 6 ) ) -RRB- cord-010119-t1x9gknd 4482 7 were be VBD cord-010119-t1x9gknd 4482 8 associated associate VBN cord-010119-t1x9gknd 4482 9 with with IN cord-010119-t1x9gknd 4482 10 suspected suspect VBN cord-010119-t1x9gknd 4482 11 bacterial bacterial JJ cord-010119-t1x9gknd 4482 12 infection infection NN cord-010119-t1x9gknd 4482 13 . . . cord-010119-t1x9gknd 4483 1 Four four CD cord-010119-t1x9gknd 4483 2 of of IN cord-010119-t1x9gknd 4483 3 the the DT cord-010119-t1x9gknd 4483 4 8 8 CD cord-010119-t1x9gknd 4483 5 patients patient NNS cord-010119-t1x9gknd 4483 6 ( ( -LRB- cord-010119-t1x9gknd 4483 7 50 50 CD cord-010119-t1x9gknd 4483 8 % % NN cord-010119-t1x9gknd 4483 9 ) ) -RRB- cord-010119-t1x9gknd 4483 10 showed show VBD cord-010119-t1x9gknd 4483 11 acute acute JJ cord-010119-t1x9gknd 4483 12 relapse relapse NN cord-010119-t1x9gknd 4483 13 coincident coincident JJ cord-010119-t1x9gknd 4483 14 with with IN cord-010119-t1x9gknd 4483 15 bacterial bacterial JJ cord-010119-t1x9gknd 4483 16 infections infection NNS cord-010119-t1x9gknd 4483 17 . . . cord-010119-t1x9gknd 4484 1 Central central JJ cord-010119-t1x9gknd 4484 2 line line NN cord-010119-t1x9gknd 4484 3 associated associate VBD cord-010119-t1x9gknd 4484 4 Staphylococcus Staphylococcus NNP cord-010119-t1x9gknd 4484 5 aureus aureus NN cord-010119-t1x9gknd 4484 6 infections infection NNS cord-010119-t1x9gknd 4484 7 occurred occur VBD cord-010119-t1x9gknd 4484 8 in in IN cord-010119-t1x9gknd 4484 9 three three CD cord-010119-t1x9gknd 4484 10 patients patient NNS cord-010119-t1x9gknd 4484 11 and and CC cord-010119-t1x9gknd 4484 12 Acinetobacter Acinetobacter NNP cord-010119-t1x9gknd 4484 13 urinary urinary JJ cord-010119-t1x9gknd 4484 14 tract tract NN cord-010119-t1x9gknd 4484 15 infection infection NN cord-010119-t1x9gknd 4484 16 was be VBD cord-010119-t1x9gknd 4484 17 reported report VBN cord-010119-t1x9gknd 4484 18 in in IN cord-010119-t1x9gknd 4484 19 one one CD cord-010119-t1x9gknd 4484 20 patient patient NN cord-010119-t1x9gknd 4484 21 . . . cord-010119-t1x9gknd 4485 1 One one CD cord-010119-t1x9gknd 4485 2 patient patient NN cord-010119-t1x9gknd 4485 3 had have VBD cord-010119-t1x9gknd 4485 4 symptoms symptom NNS cord-010119-t1x9gknd 4485 5 of of IN cord-010119-t1x9gknd 4485 6 respiratory respiratory JJ cord-010119-t1x9gknd 4485 7 infection infection NN cord-010119-t1x9gknd 4485 8 before before IN cord-010119-t1x9gknd 4485 9 the the DT cord-010119-t1x9gknd 4485 10 development development NN cord-010119-t1x9gknd 4485 11 of of IN cord-010119-t1x9gknd 4485 12 TTP TTP NNP cord-010119-t1x9gknd 4485 13 , , , cord-010119-t1x9gknd 4485 14 on on IN cord-010119-t1x9gknd 4485 15 his -PRON- PRP$ cord-010119-t1x9gknd 4485 16 initial initial NN cord-010119-t1x9gknd 4485 17 as as RB cord-010119-t1x9gknd 4485 18 well well RB cord-010119-t1x9gknd 4485 19 as as IN cord-010119-t1x9gknd 4485 20 his -PRON- PRP$ cord-010119-t1x9gknd 4485 21 relapsing relapse VBG cord-010119-t1x9gknd 4485 22 episode episode NN cord-010119-t1x9gknd 4485 23 . . . cord-010119-t1x9gknd 4486 1 Refractoriness Refractoriness NNP cord-010119-t1x9gknd 4486 2 to to IN cord-010119-t1x9gknd 4486 3 treatment treatment NN cord-010119-t1x9gknd 4486 4 was be VBD cord-010119-t1x9gknd 4486 5 demonstrated demonstrate VBN cord-010119-t1x9gknd 4486 6 in in IN cord-010119-t1x9gknd 4486 7 3 3 CD cord-010119-t1x9gknd 4486 8 patients patient NNS cord-010119-t1x9gknd 4486 9 . . . cord-010119-t1x9gknd 4487 1 It -PRON- PRP cord-010119-t1x9gknd 4487 2 was be VBD cord-010119-t1x9gknd 4487 3 associated associate VBN cord-010119-t1x9gknd 4487 4 with with IN cord-010119-t1x9gknd 4487 5 dental dental JJ cord-010119-t1x9gknd 4487 6 abscess abscess NN cord-010119-t1x9gknd 4487 7 in in IN cord-010119-t1x9gknd 4487 8 one one CD cord-010119-t1x9gknd 4487 9 patient patient NN cord-010119-t1x9gknd 4487 10 . . . cord-010119-t1x9gknd 4488 1 The the DT cord-010119-t1x9gknd 4488 2 other other JJ cord-010119-t1x9gknd 4488 3 two two CD cord-010119-t1x9gknd 4488 4 were be VBD cord-010119-t1x9gknd 4488 5 associated associate VBN cord-010119-t1x9gknd 4488 6 with with IN cord-010119-t1x9gknd 4488 7 Mycoplasma Mycoplasma NNP cord-010119-t1x9gknd 4488 8 Pneumonia Pneumonia NNP cord-010119-t1x9gknd 4488 9 . . . cord-010119-t1x9gknd 4489 1 TPE TPE NNP cord-010119-t1x9gknd 4489 2 sessions session NNS cord-010119-t1x9gknd 4489 3 were be VBD cord-010119-t1x9gknd 4489 4 continued continue VBN cord-010119-t1x9gknd 4489 5 in in IN cord-010119-t1x9gknd 4489 6 all all DT cord-010119-t1x9gknd 4489 7 refractory refractory JJ cord-010119-t1x9gknd 4489 8 patients patient NNS cord-010119-t1x9gknd 4489 9 until until IN cord-010119-t1x9gknd 4489 10 their -PRON- PRP$ cord-010119-t1x9gknd 4489 11 death death NN cord-010119-t1x9gknd 4489 12 . . . cord-010119-t1x9gknd 4490 1 Conclusion conclusion NN cord-010119-t1x9gknd 4490 2 : : : cord-010119-t1x9gknd 4491 1 In in IN cord-010119-t1x9gknd 4491 2 patients patient NNS cord-010119-t1x9gknd 4491 3 with with IN cord-010119-t1x9gknd 4491 4 idiopathic idiopathic JJ cord-010119-t1x9gknd 4491 5 TTP TTP NNP cord-010119-t1x9gknd 4491 6 refractory refractory JJ cord-010119-t1x9gknd 4491 7 to to IN cord-010119-t1x9gknd 4491 8 conventional conventional JJ cord-010119-t1x9gknd 4491 9 treatment treatment NN cord-010119-t1x9gknd 4491 10 , , , cord-010119-t1x9gknd 4491 11 a a DT cord-010119-t1x9gknd 4491 12 serious serious JJ cord-010119-t1x9gknd 4491 13 consideration consideration NN cord-010119-t1x9gknd 4491 14 should should MD cord-010119-t1x9gknd 4491 15 be be VB cord-010119-t1x9gknd 4491 16 given give VBN cord-010119-t1x9gknd 4491 17 to to IN cord-010119-t1x9gknd 4491 18 non non JJ cord-010119-t1x9gknd 4491 19 - - JJ cord-010119-t1x9gknd 4491 20 idiopathic idiopathic JJ cord-010119-t1x9gknd 4491 21 causes cause NNS cord-010119-t1x9gknd 4491 22 , , , cord-010119-t1x9gknd 4491 23 particularly particularly RB cord-010119-t1x9gknd 4491 24 the the DT cord-010119-t1x9gknd 4491 25 presence presence NN cord-010119-t1x9gknd 4491 26 of of IN cord-010119-t1x9gknd 4491 27 a a DT cord-010119-t1x9gknd 4491 28 remote remote JJ cord-010119-t1x9gknd 4491 29 source source NN cord-010119-t1x9gknd 4491 30 of of IN cord-010119-t1x9gknd 4491 31 infection infection NN cord-010119-t1x9gknd 4491 32 , , , cord-010119-t1x9gknd 4491 33 which which WDT cord-010119-t1x9gknd 4491 34 can can MD cord-010119-t1x9gknd 4491 35 be be VB cord-010119-t1x9gknd 4491 36 an an DT cord-010119-t1x9gknd 4491 37 additional additional JJ cord-010119-t1x9gknd 4491 38 triggering trigger VBG cord-010119-t1x9gknd 4491 39 factor factor NN cord-010119-t1x9gknd 4491 40 for for IN cord-010119-t1x9gknd 4491 41 their -PRON- PRP$ cord-010119-t1x9gknd 4491 42 initial initial JJ cord-010119-t1x9gknd 4491 43 and and CC cord-010119-t1x9gknd 4491 44 / / SYM cord-010119-t1x9gknd 4491 45 or or CC cord-010119-t1x9gknd 4491 46 recurrent recurrent JJ cord-010119-t1x9gknd 4491 47 episodes episode NNS cord-010119-t1x9gknd 4491 48 . . . cord-010119-t1x9gknd 4492 1 Sandra Sandra NNP cord-010119-t1x9gknd 4492 2 Satoe Satoe NNP cord-010119-t1x9gknd 4492 3 Kayano Kayano NNP cord-010119-t1x9gknd 4492 4 * * NFP cord-010119-t1x9gknd 4492 5 , , , cord-010119-t1x9gknd 4492 6 Marcos Marcos NNP cord-010119-t1x9gknd 4492 7 Paulo Paulo NNP cord-010119-t1x9gknd 4492 8 Colella Colella NNP cord-010119-t1x9gknd 4492 9 , , , cord-010119-t1x9gknd 4492 10 Rafaela Rafaela NNP cord-010119-t1x9gknd 4492 11 Guerra Guerra NNP cord-010119-t1x9gknd 4492 12 Maciel Maciel NNP cord-010119-t1x9gknd 4492 13 , , , cord-010119-t1x9gknd 4492 14 Ingrid Ingrid NNP cord-010119-t1x9gknd 4492 15 Priscila Priscila NNP cord-010119-t1x9gknd 4492 16 Ribeiro Ribeiro NNP cord-010119-t1x9gknd 4492 17 Paes Paes NNP cord-010119-t1x9gknd 4492 18 Ferraz Ferraz NNP cord-010119-t1x9gknd 4492 19 and and CC cord-010119-t1x9gknd 4492 20 Rafael Rafael NNP cord-010119-t1x9gknd 4492 21 Colella Colella NNP cord-010119-t1x9gknd 4492 22 . . . cord-010119-t1x9gknd 4493 1 A a DT cord-010119-t1x9gknd 4493 2 C C NNP cord-010119-t1x9gknd 4493 3 Camargo Camargo NNP cord-010119-t1x9gknd 4493 4 Cancer Cancer NNP cord-010119-t1x9gknd 4493 5 Center Center NNP cord-010119-t1x9gknd 4493 6 Background Background NNP cord-010119-t1x9gknd 4493 7 / / SYM cord-010119-t1x9gknd 4493 8 Case Case NNP cord-010119-t1x9gknd 4493 9 Studies Studies NNPS cord-010119-t1x9gknd 4493 10 : : : cord-010119-t1x9gknd 4493 11 Therapeutic Therapeutic NNP cord-010119-t1x9gknd 4493 12 Leukapheresis Leukapheresis NNP cord-010119-t1x9gknd 4493 13 ( ( -LRB- cord-010119-t1x9gknd 4493 14 TL TL NNP cord-010119-t1x9gknd 4493 15 ) ) -RRB- cord-010119-t1x9gknd 4493 16 has have VBZ cord-010119-t1x9gknd 4493 17 become become VBN cord-010119-t1x9gknd 4493 18 an an DT cord-010119-t1x9gknd 4493 19 ordinary ordinary JJ cord-010119-t1x9gknd 4493 20 procedure procedure NN cord-010119-t1x9gknd 4493 21 in in IN cord-010119-t1x9gknd 4493 22 low low JJ cord-010119-t1x9gknd 4493 23 body body NN cord-010119-t1x9gknd 4493 24 weight weight NN cord-010119-t1x9gknd 4493 25 children child NNS cord-010119-t1x9gknd 4493 26 with with IN cord-010119-t1x9gknd 4493 27 cancer cancer NN cord-010119-t1x9gknd 4493 28 , , , cord-010119-t1x9gknd 4493 29 and and CC cord-010119-t1x9gknd 4493 30 its -PRON- PRP$ cord-010119-t1x9gknd 4493 31 use use NN cord-010119-t1x9gknd 4493 32 over over IN cord-010119-t1x9gknd 4493 33 the the DT cord-010119-t1x9gknd 4493 34 time time NN cord-010119-t1x9gknd 4493 35 has have VBZ cord-010119-t1x9gknd 4493 36 been be VBN cord-010119-t1x9gknd 4493 37 replacing replace VBG cord-010119-t1x9gknd 4493 38 exchange exchange NN cord-010119-t1x9gknd 4493 39 transfusion transfusion NN cord-010119-t1x9gknd 4493 40 . . . cord-010119-t1x9gknd 4494 1 Leukodepletion leukodepletion NN cord-010119-t1x9gknd 4494 2 preceding precede VBG cord-010119-t1x9gknd 4494 3 chemotherapy chemotherapy NN cord-010119-t1x9gknd 4494 4 helps help VBZ cord-010119-t1x9gknd 4494 5 preventing prevent VBG cord-010119-t1x9gknd 4494 6 leukostasis leukostasis NN cord-010119-t1x9gknd 4494 7 and and CC cord-010119-t1x9gknd 4494 8 hiperviscosity hiperviscosity NN cord-010119-t1x9gknd 4494 9 , , , cord-010119-t1x9gknd 4494 10 and and CC cord-010119-t1x9gknd 4494 11 aims aim VBZ cord-010119-t1x9gknd 4494 12 to to TO cord-010119-t1x9gknd 4494 13 reduce reduce VB cord-010119-t1x9gknd 4494 14 metabolic metabolic JJ cord-010119-t1x9gknd 4494 15 and and CC cord-010119-t1x9gknd 4494 16 renal renal JJ cord-010119-t1x9gknd 4494 17 complications complication NNS cord-010119-t1x9gknd 4494 18 associated associate VBN cord-010119-t1x9gknd 4494 19 with with IN cord-010119-t1x9gknd 4494 20 cell cell NN cord-010119-t1x9gknd 4494 21 lysis lysis NN cord-010119-t1x9gknd 4494 22 . . . cord-010119-t1x9gknd 4495 1 The the DT cord-010119-t1x9gknd 4495 2 objective objective NN cord-010119-t1x9gknd 4495 3 of of IN cord-010119-t1x9gknd 4495 4 this this DT cord-010119-t1x9gknd 4495 5 study study NN cord-010119-t1x9gknd 4495 6 is be VBZ cord-010119-t1x9gknd 4495 7 to to TO cord-010119-t1x9gknd 4495 8 evaluate evaluate VB cord-010119-t1x9gknd 4495 9 the the DT cord-010119-t1x9gknd 4495 10 efficacy efficacy NN cord-010119-t1x9gknd 4495 11 and and CC cord-010119-t1x9gknd 4495 12 safety safety NN cord-010119-t1x9gknd 4495 13 of of IN cord-010119-t1x9gknd 4495 14 leukapheresis leukapheresis NN cord-010119-t1x9gknd 4495 15 procedure procedure NN cord-010119-t1x9gknd 4495 16 in in IN cord-010119-t1x9gknd 4495 17 pediatric pediatric JJ cord-010119-t1x9gknd 4495 18 patients patient NNS cord-010119-t1x9gknd 4495 19 with with IN cord-010119-t1x9gknd 4495 20 less less JJR cord-010119-t1x9gknd 4495 21 than than IN cord-010119-t1x9gknd 4495 22 10 10 CD cord-010119-t1x9gknd 4495 23 kilograms kilogram NNS cord-010119-t1x9gknd 4495 24 using use VBG cord-010119-t1x9gknd 4495 25 a a DT cord-010119-t1x9gknd 4495 26 single single JJ cord-010119-t1x9gknd 4495 27 apheresis apheresis NN cord-010119-t1x9gknd 4495 28 procedure procedure NN cord-010119-t1x9gknd 4495 29 . . . cord-010119-t1x9gknd 4496 1 Study Study NNP cord-010119-t1x9gknd 4496 2 Design Design NNP cord-010119-t1x9gknd 4496 3 / / SYM cord-010119-t1x9gknd 4496 4 Method method NN cord-010119-t1x9gknd 4496 5 : : : cord-010119-t1x9gknd 4496 6 In in IN cord-010119-t1x9gknd 4496 7 October October NNP cord-010119-t1x9gknd 4496 8 2015 2015 CD cord-010119-t1x9gknd 4496 9 and and CC cord-010119-t1x9gknd 4496 10 June June NNP cord-010119-t1x9gknd 4496 11 2016 2016 CD cord-010119-t1x9gknd 4496 12 , , , cord-010119-t1x9gknd 4496 13 two two CD cord-010119-t1x9gknd 4496 14 children child NNS cord-010119-t1x9gknd 4496 15 with with IN cord-010119-t1x9gknd 4496 16 possible possible JJ cord-010119-t1x9gknd 4496 17 leukemia leukemia NN cord-010119-t1x9gknd 4496 18 were be VBD cord-010119-t1x9gknd 4496 19 submitted submit VBN cord-010119-t1x9gknd 4496 20 to to IN cord-010119-t1x9gknd 4496 21 TL TL NNP cord-010119-t1x9gknd 4496 22 procedure procedure NN cord-010119-t1x9gknd 4496 23 . . . cord-010119-t1x9gknd 4497 1 They -PRON- PRP cord-010119-t1x9gknd 4497 2 were be VBD cord-010119-t1x9gknd 4497 3 6 6 CD cord-010119-t1x9gknd 4497 4 and and CC cord-010119-t1x9gknd 4497 5 9 9 CD cord-010119-t1x9gknd 4497 6 months month NNS cord-010119-t1x9gknd 4497 7 old old JJ cord-010119-t1x9gknd 4497 8 , , , cord-010119-t1x9gknd 4497 9 and and CC cord-010119-t1x9gknd 4497 10 weighted weight VBD cord-010119-t1x9gknd 4497 11 7,0 7,0 CD cord-010119-t1x9gknd 4497 12 and and CC cord-010119-t1x9gknd 4497 13 9,1 9,1 CD cord-010119-t1x9gknd 4497 14 kilograms kilogram NNS cord-010119-t1x9gknd 4497 15 . . . cord-010119-t1x9gknd 4498 1 central central JJ cord-010119-t1x9gknd 4498 2 venous venous JJ cord-010119-t1x9gknd 4498 3 catheters catheter NNS cord-010119-t1x9gknd 4498 4 were be VBD cord-010119-t1x9gknd 4498 5 placed place VBN cord-010119-t1x9gknd 4498 6 , , , cord-010119-t1x9gknd 4498 7 and and CC cord-010119-t1x9gknd 4498 8 apheresis apheresis NN cord-010119-t1x9gknd 4498 9 were be VBD cord-010119-t1x9gknd 4498 10 performed perform VBN cord-010119-t1x9gknd 4498 11 using use VBG cord-010119-t1x9gknd 4498 12 a a DT cord-010119-t1x9gknd 4498 13 continuous continuous JJ cord-010119-t1x9gknd 4498 14 flow flow NN cord-010119-t1x9gknd 4498 15 apheresis apheresis NN cord-010119-t1x9gknd 4498 16 system system NN cord-010119-t1x9gknd 4498 17 . . . cord-010119-t1x9gknd 4499 1 The the DT cord-010119-t1x9gknd 4499 2 device device NN cord-010119-t1x9gknd 4499 3 was be VBD cord-010119-t1x9gknd 4499 4 primed prime VBN cord-010119-t1x9gknd 4499 5 with with IN cord-010119-t1x9gknd 4499 6 285 285 CD cord-010119-t1x9gknd 4499 7 ml ml NNS cord-010119-t1x9gknd 4499 8 of of IN cord-010119-t1x9gknd 4499 9 ABO ABO NNP cord-010119-t1x9gknd 4499 10 , , , cord-010119-t1x9gknd 4499 11 Rh Rh NNP cord-010119-t1x9gknd 4499 12 and and CC cord-010119-t1x9gknd 4499 13 Kell Kell NNP cord-010119-t1x9gknd 4499 14 compatible compatible JJ cord-010119-t1x9gknd 4499 15 , , , cord-010119-t1x9gknd 4499 16 leukocyte leukocyte NN cord-010119-t1x9gknd 4499 17 - - HYPH cord-010119-t1x9gknd 4499 18 reduced reduce VBN cord-010119-t1x9gknd 4499 19 , , , cord-010119-t1x9gknd 4499 20 irradiated irradiate VBN cord-010119-t1x9gknd 4499 21 , , , cord-010119-t1x9gknd 4499 22 64 64 CD cord-010119-t1x9gknd 4499 23 % % NN cord-010119-t1x9gknd 4499 24 hematocrit hematocrit NN cord-010119-t1x9gknd 4499 25 packed pack VBN cord-010119-t1x9gknd 4499 26 RBCs rbc NNS cord-010119-t1x9gknd 4499 27 , , , cord-010119-t1x9gknd 4499 28 and and CC cord-010119-t1x9gknd 4499 29 the the DT cord-010119-t1x9gknd 4499 30 anticoagulant anticoagulant NN cord-010119-t1x9gknd 4499 31 used use VBN cord-010119-t1x9gknd 4499 32 was be VBD cord-010119-t1x9gknd 4499 33 ACD ACD NNP cord-010119-t1x9gknd 4499 34 - - HYPH cord-010119-t1x9gknd 4499 35 A a NN cord-010119-t1x9gknd 4499 36 plus plus CC cord-010119-t1x9gknd 4499 37 heparin heparin NN cord-010119-t1x9gknd 4499 38 ( ( -LRB- cord-010119-t1x9gknd 4499 39 750 750 CD cord-010119-t1x9gknd 4499 40 mL ml NN cord-010119-t1x9gknd 4499 41 of of IN cord-010119-t1x9gknd 4499 42 ACD ACD NNP cord-010119-t1x9gknd 4499 43 - - HYPH cord-010119-t1x9gknd 4499 44 A a NN cord-010119-t1x9gknd 4499 45 and and CC cord-010119-t1x9gknd 4499 46 7,500 7,500 CD cord-010119-t1x9gknd 4499 47 units unit NNS cord-010119-t1x9gknd 4499 48 of of IN cord-010119-t1x9gknd 4499 49 heparin heparin NN cord-010119-t1x9gknd 4499 50 ) ) -RRB- cord-010119-t1x9gknd 4499 51 , , , cord-010119-t1x9gknd 4499 52 at at IN cord-010119-t1x9gknd 4499 53 a a DT cord-010119-t1x9gknd 4499 54 blood blood NN cord-010119-t1x9gknd 4499 55 to to IN cord-010119-t1x9gknd 4499 56 anticoagulant anticoagulant JJ cord-010119-t1x9gknd 4499 57 ratio ratio NN cord-010119-t1x9gknd 4499 58 of of IN cord-010119-t1x9gknd 4499 59 25:1 25:1 CD cord-010119-t1x9gknd 4499 60 . . . cord-010119-t1x9gknd 4500 1 A a DT cord-010119-t1x9gknd 4500 2 complete complete JJ cord-010119-t1x9gknd 4500 3 blood blood NN cord-010119-t1x9gknd 4500 4 count count NN cord-010119-t1x9gknd 4500 5 was be VBD cord-010119-t1x9gknd 4500 6 determined determine VBN cord-010119-t1x9gknd 4500 7 before before IN cord-010119-t1x9gknd 4500 8 and and CC cord-010119-t1x9gknd 4500 9 after after IN cord-010119-t1x9gknd 4500 10 apheresis apheresis NN cord-010119-t1x9gknd 4500 11 . . . cord-010119-t1x9gknd 4501 1 The the DT cord-010119-t1x9gknd 4501 2 room room NN cord-010119-t1x9gknd 4501 3 was be VBD cord-010119-t1x9gknd 4501 4 heated heat VBN cord-010119-t1x9gknd 4501 5 to to TO cord-010119-t1x9gknd 4501 6 avoid avoid VB cord-010119-t1x9gknd 4501 7 hypothermia hypothermia NN cord-010119-t1x9gknd 4501 8 , , , cord-010119-t1x9gknd 4501 9 and and CC cord-010119-t1x9gknd 4501 10 ionized ionized JJ cord-010119-t1x9gknd 4501 11 calcium calcium NN cord-010119-t1x9gknd 4501 12 was be VBD cord-010119-t1x9gknd 4501 13 measured measure VBN cord-010119-t1x9gknd 4501 14 every every DT cord-010119-t1x9gknd 4501 15 30 30 CD cord-010119-t1x9gknd 4501 16 minutes minute NNS cord-010119-t1x9gknd 4501 17 to to TO cord-010119-t1x9gknd 4501 18 prevent prevent VB cord-010119-t1x9gknd 4501 19 hypocalcemia hypocalcemia NN cord-010119-t1x9gknd 4501 20 . . . cord-010119-t1x9gknd 4502 1 During during IN cord-010119-t1x9gknd 4502 2 the the DT cord-010119-t1x9gknd 4502 3 collection collection NN cord-010119-t1x9gknd 4502 4 , , , cord-010119-t1x9gknd 4502 5 changes change NNS cord-010119-t1x9gknd 4502 6 in in IN cord-010119-t1x9gknd 4502 7 blood blood NN cord-010119-t1x9gknd 4502 8 pressure pressure NN cord-010119-t1x9gknd 4502 9 , , , cord-010119-t1x9gknd 4502 10 oxygen oxygen NN cord-010119-t1x9gknd 4502 11 saturation saturation NN cord-010119-t1x9gknd 4502 12 and and CC cord-010119-t1x9gknd 4502 13 heart heart NN cord-010119-t1x9gknd 4502 14 rate rate NN cord-010119-t1x9gknd 4502 15 were be VBD cord-010119-t1x9gknd 4502 16 observed observe VBN cord-010119-t1x9gknd 4502 17 . . . cord-010119-t1x9gknd 4503 1 Net net JJ cord-010119-t1x9gknd 4503 2 fluid fluid JJ cord-010119-t1x9gknd 4503 3 balance balance NN cord-010119-t1x9gknd 4503 4 was be VBD cord-010119-t1x9gknd 4503 5 calculated calculate VBN cord-010119-t1x9gknd 4503 6 as as IN cord-010119-t1x9gknd 4503 7 the the DT cord-010119-t1x9gknd 4503 8 sum sum NN cord-010119-t1x9gknd 4503 9 of of IN cord-010119-t1x9gknd 4503 10 the the DT cord-010119-t1x9gknd 4503 11 volume volume NN cord-010119-t1x9gknd 4503 12 of of IN cord-010119-t1x9gknd 4503 13 anticoagulant anticoagulant NN cord-010119-t1x9gknd 4503 14 , , , cord-010119-t1x9gknd 4503 15 cation cation NN cord-010119-t1x9gknd 4503 16 and and CC cord-010119-t1x9gknd 4503 17 nondiverted nondiverted JJ cord-010119-t1x9gknd 4503 18 apheresis apheresis NN cord-010119-t1x9gknd 4503 19 prime prime NNP cord-010119-t1x9gknd 4503 20 solutions solutions NNPS cord-010119-t1x9gknd 4503 21 minus minus CC cord-010119-t1x9gknd 4503 22 the the DT cord-010119-t1x9gknd 4503 23 product product NN cord-010119-t1x9gknd 4503 24 volume volume NN cord-010119-t1x9gknd 4503 25 . . . cord-010119-t1x9gknd 4504 1 When when WRB cord-010119-t1x9gknd 4504 2 the the DT cord-010119-t1x9gknd 4504 3 procedure procedure NN cord-010119-t1x9gknd 4504 4 was be VBD cord-010119-t1x9gknd 4504 5 completed complete VBN cord-010119-t1x9gknd 4504 6 , , , cord-010119-t1x9gknd 4504 7 the the DT cord-010119-t1x9gknd 4504 8 blood blood NN cord-010119-t1x9gknd 4504 9 that that WDT cord-010119-t1x9gknd 4504 10 filled fill VBD cord-010119-t1x9gknd 4504 11 the the DT cord-010119-t1x9gknd 4504 12 apheresis apheresis NN cord-010119-t1x9gknd 4504 13 tubing tubing NN cord-010119-t1x9gknd 4504 14 was be VBD cord-010119-t1x9gknd 4504 15 discarded discard VBN cord-010119-t1x9gknd 4504 16 . . . cord-010119-t1x9gknd 4505 1 The the DT cord-010119-t1x9gknd 4505 2 patients patient NNS cord-010119-t1x9gknd 4505 3 were be VBD cord-010119-t1x9gknd 4505 4 in in IN cord-010119-t1x9gknd 4505 5 the the DT cord-010119-t1x9gknd 4505 6 intensive intensive JJ cord-010119-t1x9gknd 4505 7 care care NN cord-010119-t1x9gknd 4505 8 unit unit NN cord-010119-t1x9gknd 4505 9 ( ( -LRB- cord-010119-t1x9gknd 4505 10 ICU ICU NNP cord-010119-t1x9gknd 4505 11 ) ) -RRB- cord-010119-t1x9gknd 4505 12 under under IN cord-010119-t1x9gknd 4505 13 the the DT cord-010119-t1x9gknd 4505 14 supervision supervision NN cord-010119-t1x9gknd 4505 15 of of IN cord-010119-t1x9gknd 4505 16 a a DT cord-010119-t1x9gknd 4505 17 pediatric pediatric JJ cord-010119-t1x9gknd 4505 18 physician physician NN cord-010119-t1x9gknd 4505 19 and and CC cord-010119-t1x9gknd 4505 20 ICU ICU NNP cord-010119-t1x9gknd 4505 21 nurse nurse NN cord-010119-t1x9gknd 4505 22 who who WP cord-010119-t1x9gknd 4505 23 were be VBD cord-010119-t1x9gknd 4505 24 aware aware JJ cord-010119-t1x9gknd 4505 25 of of IN cord-010119-t1x9gknd 4505 26 potential potential JJ cord-010119-t1x9gknd 4505 27 adverse adverse JJ cord-010119-t1x9gknd 4505 28 events event NNS cord-010119-t1x9gknd 4505 29 , , , cord-010119-t1x9gknd 4505 30 and and CC cord-010119-t1x9gknd 4505 31 the the DT cord-010119-t1x9gknd 4505 32 procedure procedure NN cord-010119-t1x9gknd 4505 33 were be VBD cord-010119-t1x9gknd 4505 34 performed perform VBN cord-010119-t1x9gknd 4505 35 by by IN cord-010119-t1x9gknd 4505 36 two two CD cord-010119-t1x9gknd 4505 37 hematology hematology NN cord-010119-t1x9gknd 4505 38 physicians physician NNS cord-010119-t1x9gknd 4505 39 and and CC cord-010119-t1x9gknd 4505 40 the the DT cord-010119-t1x9gknd 4505 41 nurse nurse NN cord-010119-t1x9gknd 4505 42 practitioner practitioner NN cord-010119-t1x9gknd 4505 43 . . . cord-010119-t1x9gknd 4506 1 Results/ Results/ . cord-010119-t1x9gknd 4507 1 Finding find VBG cord-010119-t1x9gknd 4507 2 : : : cord-010119-t1x9gknd 4507 3 The the DT cord-010119-t1x9gknd 4507 4 white white JJ cord-010119-t1x9gknd 4507 5 blood blood NN cord-010119-t1x9gknd 4507 6 cell cell NN cord-010119-t1x9gknd 4507 7 ( ( -LRB- cord-010119-t1x9gknd 4507 8 WBC WBC NNP cord-010119-t1x9gknd 4507 9 ) ) -RRB- cord-010119-t1x9gknd 4507 10 in in IN cord-010119-t1x9gknd 4507 11 blood blood NN cord-010119-t1x9gknd 4507 12 was be VBD cord-010119-t1x9gknd 4507 13 counted count VBN cord-010119-t1x9gknd 4507 14 immediately immediately RB cord-010119-t1x9gknd 4507 15 before before IN cord-010119-t1x9gknd 4507 16 apheresis apheresis NN cord-010119-t1x9gknd 4507 17 in in IN cord-010119-t1x9gknd 4507 18 both both DT cord-010119-t1x9gknd 4507 19 subjects subject NNS cord-010119-t1x9gknd 4507 20 , , , cord-010119-t1x9gknd 4507 21 and and CC cord-010119-t1x9gknd 4507 22 were be VBD cord-010119-t1x9gknd 4507 23 120.000 120.000 CD cord-010119-t1x9gknd 4507 24 and and CC cord-010119-t1x9gknd 4507 25 150.000/ 150.000/ CD cord-010119-t1x9gknd 4507 26 mm mm CD cord-010119-t1x9gknd 4507 27 3 3 CD cord-010119-t1x9gknd 4507 28 . . . cord-010119-t1x9gknd 4508 1 The the DT cord-010119-t1x9gknd 4508 2 formula formula NN cord-010119-t1x9gknd 4508 3 " " `` cord-010119-t1x9gknd 4508 4 Collection Collection NNP cord-010119-t1x9gknd 4508 5 Pump Pump NNP cord-010119-t1x9gknd 4508 6 Flow flow VB cord-010119-t1x9gknd 4508 7 5 5 CD cord-010119-t1x9gknd 4508 8 0,0003 0,0003 CD cord-010119-t1x9gknd 4509 1 x x SYM cord-010119-t1x9gknd 4509 2 Inlet Inlet NNP cord-010119-t1x9gknd 4509 3 Flow Flow NNP cord-010119-t1x9gknd 4510 1 x x NFP cord-010119-t1x9gknd 4510 2 Preapheresis Preapheresis NNP cord-010119-t1x9gknd 4510 3 WBC WBC NNP cord-010119-t1x9gknd 4510 4 count count NN cord-010119-t1x9gknd 4510 5 " " '' cord-010119-t1x9gknd 4510 6 was be VBD cord-010119-t1x9gknd 4510 7 used use VBN cord-010119-t1x9gknd 4510 8 with with IN cord-010119-t1x9gknd 4510 9 the the DT cord-010119-t1x9gknd 4510 10 goal goal NN cord-010119-t1x9gknd 4510 11 of of IN cord-010119-t1x9gknd 4510 12 removing remove VBG cord-010119-t1x9gknd 4510 13 up up RP cord-010119-t1x9gknd 4510 14 to to TO cord-010119-t1x9gknd 4510 15 3 3 CD cord-010119-t1x9gknd 4510 16 x x SYM cord-010119-t1x9gknd 4510 17 10 10 CD cord-010119-t1x9gknd 4510 18 9 9 CD cord-010119-t1x9gknd 4510 19 leukocytes leukocyte NNS cord-010119-t1x9gknd 4510 20 / / SYM cord-010119-t1x9gknd 4510 21 mL. mL. NNS cord-010119-t1x9gknd 4510 22 A a DT cord-010119-t1x9gknd 4510 23 single single JJ cord-010119-t1x9gknd 4510 24 leukapheresis leukapheresis NN cord-010119-t1x9gknd 4510 25 procedure procedure NN cord-010119-t1x9gknd 4510 26 was be VBD cord-010119-t1x9gknd 4510 27 performed perform VBN cord-010119-t1x9gknd 4510 28 with with IN cord-010119-t1x9gknd 4510 29 2 2 CD cord-010119-t1x9gknd 4510 30 total total JJ cord-010119-t1x9gknd 4510 31 blood blood NN cord-010119-t1x9gknd 4510 32 volume volume NN cord-010119-t1x9gknd 4510 33 processed process VBN cord-010119-t1x9gknd 4510 34 per per IN cord-010119-t1x9gknd 4510 35 patient patient NN cord-010119-t1x9gknd 4510 36 . . . cord-010119-t1x9gknd 4511 1 Immediately immediately RB cord-010119-t1x9gknd 4511 2 after after IN cord-010119-t1x9gknd 4511 3 the the DT cord-010119-t1x9gknd 4511 4 2-hour 2-hour CD cord-010119-t1x9gknd 4511 5 procedures procedure NNS cord-010119-t1x9gknd 4511 6 , , , cord-010119-t1x9gknd 4511 7 WBC WBC NNP cord-010119-t1x9gknd 4511 8 count count NN cord-010119-t1x9gknd 4511 9 were be VBD cord-010119-t1x9gknd 4511 10 74.000 74.000 CD cord-010119-t1x9gknd 4511 11 and and CC cord-010119-t1x9gknd 4511 12 92.000 92.000 CD cord-010119-t1x9gknd 4512 1 WBC WBC NNP cord-010119-t1x9gknd 4512 2 / / SYM cord-010119-t1x9gknd 4512 3 mm3 mm3 NNS cord-010119-t1x9gknd 4512 4 , , , cord-010119-t1x9gknd 4512 5 and and CC cord-010119-t1x9gknd 4512 6 12-hour 12-hour CD cord-010119-t1x9gknd 4512 7 post post NN cord-010119-t1x9gknd 4512 8 TL TL NNP cord-010119-t1x9gknd 4512 9 , , , cord-010119-t1x9gknd 4512 10 WBC WBC NNP cord-010119-t1x9gknd 4512 11 count count NN cord-010119-t1x9gknd 4512 12 were be VBD cord-010119-t1x9gknd 4512 13 respectively respectively RB cord-010119-t1x9gknd 4512 14 45.000 45.000 CD cord-010119-t1x9gknd 4512 15 and and CC cord-010119-t1x9gknd 4512 16 70.000 70.000 CD cord-010119-t1x9gknd 4512 17 / / SYM cord-010119-t1x9gknd 4512 18 mm3 mm3 NNS cord-010119-t1x9gknd 4512 19 . . . cord-010119-t1x9gknd 4513 1 Net net JJ cord-010119-t1x9gknd 4513 2 fluid fluid JJ cord-010119-t1x9gknd 4513 3 balance balance NN cord-010119-t1x9gknd 4513 4 was be VBD cord-010119-t1x9gknd 4513 5 zero zero CD cord-010119-t1x9gknd 4513 6 in in IN cord-010119-t1x9gknd 4513 7 both both DT cord-010119-t1x9gknd 4513 8 procedures procedure NNS cord-010119-t1x9gknd 4513 9 , , , cord-010119-t1x9gknd 4513 10 and and CC cord-010119-t1x9gknd 4513 11 the the DT cord-010119-t1x9gknd 4513 12 patients patient NNS cord-010119-t1x9gknd 4513 13 required require VBD cord-010119-t1x9gknd 4513 14 no no DT cord-010119-t1x9gknd 4513 15 transfusion transfusion NN cord-010119-t1x9gknd 4513 16 . . . cord-010119-t1x9gknd 4514 1 Conclusion conclusion NN cord-010119-t1x9gknd 4514 2 : : : cord-010119-t1x9gknd 4515 1 TL TL NNP cord-010119-t1x9gknd 4515 2 was be VBD cord-010119-t1x9gknd 4515 3 safe safe JJ cord-010119-t1x9gknd 4515 4 and and CC cord-010119-t1x9gknd 4515 5 efficient efficient JJ cord-010119-t1x9gknd 4515 6 . . . cord-010119-t1x9gknd 4516 1 Experience experience NN cord-010119-t1x9gknd 4516 2 with with IN cord-010119-t1x9gknd 4516 3 leukodepletion leukodepletion NN cord-010119-t1x9gknd 4516 4 in in IN cord-010119-t1x9gknd 4516 5 infants infant NNS cord-010119-t1x9gknd 4516 6 is be VBZ cord-010119-t1x9gknd 4516 7 limited limited JJ cord-010119-t1x9gknd 4516 8 , , , cord-010119-t1x9gknd 4516 9 and and CC cord-010119-t1x9gknd 4516 10 a a DT cord-010119-t1x9gknd 4516 11 procedure procedure NN cord-010119-t1x9gknd 4516 12 in in IN cord-010119-t1x9gknd 4516 13 children child NNS cord-010119-t1x9gknd 4516 14 weighing weigh VBG cord-010119-t1x9gknd 4516 15 10 10 CD cord-010119-t1x9gknd 4516 16 kg kg NNS cord-010119-t1x9gknd 4516 17 or or CC cord-010119-t1x9gknd 4516 18 less less JJR cord-010119-t1x9gknd 4516 19 needs need VBZ cord-010119-t1x9gknd 4516 20 forethought forethought NN cord-010119-t1x9gknd 4516 21 and and CC cord-010119-t1x9gknd 4516 22 a a DT cord-010119-t1x9gknd 4516 23 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 4516 24 effort effort NN cord-010119-t1x9gknd 4516 25 , , , cord-010119-t1x9gknd 4516 26 hence hence RB cord-010119-t1x9gknd 4516 27 operators operator NNS cord-010119-t1x9gknd 4516 28 need need VBP cord-010119-t1x9gknd 4516 29 to to TO cord-010119-t1x9gknd 4516 30 customize customize VB cord-010119-t1x9gknd 4516 31 procedures procedure NNS cord-010119-t1x9gknd 4516 32 for for IN cord-010119-t1x9gknd 4516 33 safe safe JJ cord-010119-t1x9gknd 4516 34 collection collection NN cord-010119-t1x9gknd 4516 35 . . . cord-010119-t1x9gknd 4517 1 However however RB cord-010119-t1x9gknd 4517 2 , , , cord-010119-t1x9gknd 4517 3 despite despite IN cord-010119-t1x9gknd 4517 4 the the DT cord-010119-t1x9gknd 4517 5 potential potential JJ cord-010119-t1x9gknd 4517 6 complications complication NNS cord-010119-t1x9gknd 4517 7 that that WDT cord-010119-t1x9gknd 4517 8 may may MD cord-010119-t1x9gknd 4517 9 occur occur VB cord-010119-t1x9gknd 4517 10 ( ( -LRB- cord-010119-t1x9gknd 4517 11 placement placement NN cord-010119-t1x9gknd 4517 12 of of IN cord-010119-t1x9gknd 4517 13 adequate adequate JJ cord-010119-t1x9gknd 4517 14 vascular vascular JJ cord-010119-t1x9gknd 4517 15 access access NN cord-010119-t1x9gknd 4517 16 , , , cord-010119-t1x9gknd 4517 17 management management NN cord-010119-t1x9gknd 4517 18 of of IN cord-010119-t1x9gknd 4517 19 low low JJ cord-010119-t1x9gknd 4517 20 extracorporeal extracorporeal JJ cord-010119-t1x9gknd 4517 21 blood blood NN cord-010119-t1x9gknd 4517 22 volume volume NN cord-010119-t1x9gknd 4517 23 , , , cord-010119-t1x9gknd 4517 24 anticoagulant anticoagulant NN cord-010119-t1x9gknd 4517 25 - - HYPH cord-010119-t1x9gknd 4517 26 related relate VBN cord-010119-t1x9gknd 4517 27 toxicity toxicity NN cord-010119-t1x9gknd 4517 28 with with IN cord-010119-t1x9gknd 4517 29 metabolic metabolic JJ cord-010119-t1x9gknd 4517 30 and and CC cord-010119-t1x9gknd 4517 31 hematologic hematologic JJ cord-010119-t1x9gknd 4517 32 issues issue NNS cord-010119-t1x9gknd 4517 33 ) ) -RRB- cord-010119-t1x9gknd 4517 34 , , , cord-010119-t1x9gknd 4517 35 remains remain VBZ cord-010119-t1x9gknd 4517 36 an an DT cord-010119-t1x9gknd 4517 37 excellent excellent JJ cord-010119-t1x9gknd 4517 38 source source NN cord-010119-t1x9gknd 4517 39 for for IN cord-010119-t1x9gknd 4517 40 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4517 41 in in IN cord-010119-t1x9gknd 4517 42 hematologic hematologic JJ cord-010119-t1x9gknd 4517 43 malignant malignant JJ cord-010119-t1x9gknd 4517 44 diseases disease NNS cord-010119-t1x9gknd 4517 45 . . . cord-010119-t1x9gknd 4518 1 Background Background NNP cord-010119-t1x9gknd 4518 2 / / SYM cord-010119-t1x9gknd 4518 3 Case Case NNP cord-010119-t1x9gknd 4518 4 Studies Studies NNPS cord-010119-t1x9gknd 4518 5 : : : cord-010119-t1x9gknd 4519 1 Nationwide nationwide JJ cord-010119-t1x9gknd 4519 2 apheresis apheresis NN cord-010119-t1x9gknd 4519 3 registry registry NN cord-010119-t1x9gknd 4519 4 can can MD cord-010119-t1x9gknd 4519 5 give give VB cord-010119-t1x9gknd 4519 6 us -PRON- PRP cord-010119-t1x9gknd 4519 7 information information NN cord-010119-t1x9gknd 4519 8 on on IN cord-010119-t1x9gknd 4519 9 the the DT cord-010119-t1x9gknd 4519 10 current current JJ cord-010119-t1x9gknd 4519 11 status status NN cord-010119-t1x9gknd 4519 12 and and CC cord-010119-t1x9gknd 4519 13 trend trend NN cord-010119-t1x9gknd 4519 14 regarding regard VBG cord-010119-t1x9gknd 4519 15 apheresis apheresis NN cord-010119-t1x9gknd 4519 16 procedures procedure NNS cord-010119-t1x9gknd 4519 17 . . . cord-010119-t1x9gknd 4520 1 Data datum NNS cord-010119-t1x9gknd 4520 2 can can MD cord-010119-t1x9gknd 4520 3 be be VB cord-010119-t1x9gknd 4520 4 compared compare VBN cord-010119-t1x9gknd 4520 5 with with IN cord-010119-t1x9gknd 4520 6 other other JJ cord-010119-t1x9gknd 4520 7 regions region NNS cord-010119-t1x9gknd 4520 8 to to TO cord-010119-t1x9gknd 4520 9 find find VB cord-010119-t1x9gknd 4520 10 and and CC cord-010119-t1x9gknd 4520 11 understand understand VB cord-010119-t1x9gknd 4520 12 differences difference NNS cord-010119-t1x9gknd 4520 13 in in IN cord-010119-t1x9gknd 4520 14 perspectives perspective NNS cord-010119-t1x9gknd 4520 15 , , , cord-010119-t1x9gknd 4520 16 indications indication NNS cord-010119-t1x9gknd 4520 17 , , , cord-010119-t1x9gknd 4520 18 technology technology NN cord-010119-t1x9gknd 4520 19 , , , cord-010119-t1x9gknd 4520 20 and and CC cord-010119-t1x9gknd 4520 21 clinical clinical JJ cord-010119-t1x9gknd 4520 22 practice practice NN cord-010119-t1x9gknd 4520 23 . . . cord-010119-t1x9gknd 4521 1 The the DT cord-010119-t1x9gknd 4521 2 Korean Korean NNP cord-010119-t1x9gknd 4521 3 Society Society NNP cord-010119-t1x9gknd 4521 4 for for IN cord-010119-t1x9gknd 4521 5 Apheresis Apheresis NNP cord-010119-t1x9gknd 4521 6 ( ( -LRB- cord-010119-t1x9gknd 4521 7 KSFA KSFA NNP cord-010119-t1x9gknd 4521 8 ) ) -RRB- cord-010119-t1x9gknd 4521 9 has have VBZ cord-010119-t1x9gknd 4521 10 launched launch VBN cord-010119-t1x9gknd 4521 11 an an DT cord-010119-t1x9gknd 4521 12 online online JJ cord-010119-t1x9gknd 4521 13 web web NN cord-010119-t1x9gknd 4521 14 based base VBN cord-010119-t1x9gknd 4521 15 registry registry NN cord-010119-t1x9gknd 4521 16 system system NN cord-010119-t1x9gknd 4521 17 for for IN cord-010119-t1x9gknd 4521 18 apheresis apheresis NN cord-010119-t1x9gknd 4521 19 procedures procedure NNS cord-010119-t1x9gknd 4521 20 since since IN cord-010119-t1x9gknd 4521 21 2006 2006 CD cord-010119-t1x9gknd 4521 22 . . . cord-010119-t1x9gknd 4522 1 We -PRON- PRP cord-010119-t1x9gknd 4522 2 report report VBP cord-010119-t1x9gknd 4522 3 the the DT cord-010119-t1x9gknd 4522 4 data datum NNS cord-010119-t1x9gknd 4522 5 from from IN cord-010119-t1x9gknd 4522 6 the the DT cord-010119-t1x9gknd 4522 7 year year NN cord-010119-t1x9gknd 4522 8 2016 2016 CD cord-010119-t1x9gknd 4522 9 . . . cord-010119-t1x9gknd 4523 1 Study Study NNP cord-010119-t1x9gknd 4523 2 Design Design NNP cord-010119-t1x9gknd 4523 3 / / SYM cord-010119-t1x9gknd 4523 4 Method method NN cord-010119-t1x9gknd 4523 5 : : : cord-010119-t1x9gknd 4523 6 The the DT cord-010119-t1x9gknd 4523 7 registry registry NN cord-010119-t1x9gknd 4523 8 is be VBZ cord-010119-t1x9gknd 4523 9 consisted consist VBN cord-010119-t1x9gknd 4523 10 of of IN cord-010119-t1x9gknd 4523 11 two two CD cord-010119-t1x9gknd 4523 12 sub sub NN cord-010119-t1x9gknd 4523 13 - - NNS cord-010119-t1x9gknd 4523 14 registries registry NNS cord-010119-t1x9gknd 4523 15 . . . cord-010119-t1x9gknd 4524 1 One one CD cord-010119-t1x9gknd 4524 2 addresses address VBZ cord-010119-t1x9gknd 4524 3 the the DT cord-010119-t1x9gknd 4524 4 overall overall JJ cord-010119-t1x9gknd 4524 5 aspects aspect NNS cord-010119-t1x9gknd 4524 6 of of IN cord-010119-t1x9gknd 4524 7 apheresis apheresis NN cord-010119-t1x9gknd 4524 8 procedures procedure NNS cord-010119-t1x9gknd 4524 9 performed perform VBN cord-010119-t1x9gknd 4524 10 at at IN cord-010119-t1x9gknd 4524 11 each each DT cord-010119-t1x9gknd 4524 12 institute institute NN cord-010119-t1x9gknd 4524 13 , , , cord-010119-t1x9gknd 4524 14 and and CC cord-010119-t1x9gknd 4524 15 the the DT cord-010119-t1x9gknd 4524 16 other other JJ cord-010119-t1x9gknd 4524 17 is be VBZ cord-010119-t1x9gknd 4524 18 focused focus VBN cord-010119-t1x9gknd 4524 19 on on IN cord-010119-t1x9gknd 4524 20 therapeutic therapeutic JJ cord-010119-t1x9gknd 4524 21 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 4524 22 procedures procedure NNS cord-010119-t1x9gknd 4524 23 . . . cord-010119-t1x9gknd 4525 1 Data Data NNP cord-010119-t1x9gknd 4525 2 is be VBZ cord-010119-t1x9gknd 4525 3 registered register VBN cord-010119-t1x9gknd 4525 4 by by IN cord-010119-t1x9gknd 4525 5 voluntarily voluntarily RB cord-010119-t1x9gknd 4525 6 participating participate VBG cord-010119-t1x9gknd 4525 7 hospitals hospital NNS cord-010119-t1x9gknd 4525 8 in in IN cord-010119-t1x9gknd 4525 9 Korea Korea NNP cord-010119-t1x9gknd 4525 10 . . . cord-010119-t1x9gknd 4526 1 Results/ Results/ . cord-010119-t1x9gknd 4527 1 Finding finding NN cord-010119-t1x9gknd 4527 2 : : : cord-010119-t1x9gknd 4528 1 A a DT cord-010119-t1x9gknd 4528 2 total total NN cord-010119-t1x9gknd 4528 3 of of IN cord-010119-t1x9gknd 4528 4 13,302 13,302 CD cord-010119-t1x9gknd 4528 5 apheresis apheresis NN cord-010119-t1x9gknd 4528 6 procedures procedure NNS cord-010119-t1x9gknd 4528 7 were be VBD cord-010119-t1x9gknd 4528 8 performed perform VBN cord-010119-t1x9gknd 4528 9 at at IN cord-010119-t1x9gknd 4528 10 37 37 CD cord-010119-t1x9gknd 4528 11 hospitals hospital NNS cord-010119-t1x9gknd 4528 12 . . . cord-010119-t1x9gknd 4529 1 Therapeutic therapeutic JJ cord-010119-t1x9gknd 4529 2 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 4529 3 was be VBD cord-010119-t1x9gknd 4529 4 the the DT cord-010119-t1x9gknd 4529 5 most most RBS cord-010119-t1x9gknd 4529 6 frequent frequent JJ cord-010119-t1x9gknd 4529 7 procedure procedure NN cord-010119-t1x9gknd 4529 8 ( ( -LRB- cord-010119-t1x9gknd 4529 9 50.4 50.4 CD cord-010119-t1x9gknd 4529 10 % % NN cord-010119-t1x9gknd 4529 11 ) ) -RRB- cord-010119-t1x9gknd 4529 12 followed follow VBN cord-010119-t1x9gknd 4529 13 by by IN cord-010119-t1x9gknd 4529 14 autologous autologous JJ cord-010119-t1x9gknd 4529 15 peripheral peripheral JJ cord-010119-t1x9gknd 4529 16 blood blood NN cord-010119-t1x9gknd 4529 17 stem stem NN cord-010119-t1x9gknd 4529 18 cell cell NN cord-010119-t1x9gknd 4529 19 ( ( -LRB- cord-010119-t1x9gknd 4529 20 PBSC PBSC NNP cord-010119-t1x9gknd 4529 21 ) ) -RRB- cord-010119-t1x9gknd 4529 22 collection collection NN cord-010119-t1x9gknd 4529 23 ( ( -LRB- cord-010119-t1x9gknd 4529 24 23.9 23.9 CD cord-010119-t1x9gknd 4529 25 % % NN cord-010119-t1x9gknd 4529 26 ) ) -RRB- cord-010119-t1x9gknd 4529 27 , , , cord-010119-t1x9gknd 4529 28 allogeneic allogeneic IN cord-010119-t1x9gknd 4529 29 PBSC PBSC NNP cord-010119-t1x9gknd 4529 30 collection collection NN cord-010119-t1x9gknd 4529 31 ( ( -LRB- cord-010119-t1x9gknd 4529 32 11.0 11.0 CD cord-010119-t1x9gknd 4529 33 % % NN cord-010119-t1x9gknd 4529 34 ) ) -RRB- cord-010119-t1x9gknd 4529 35 , , , cord-010119-t1x9gknd 4529 36 donor donor NN cord-010119-t1x9gknd 4529 37 leukapheresis leukapheresis NN cord-010119-t1x9gknd 4529 38 ( ( -LRB- cord-010119-t1x9gknd 4529 39 4.0 4.0 CD cord-010119-t1x9gknd 4529 40 % % NN cord-010119-t1x9gknd 4529 41 ) ) -RRB- cord-010119-t1x9gknd 4529 42 , , , cord-010119-t1x9gknd 4529 43 and and CC cord-010119-t1x9gknd 4529 44 therapeutic therapeutic JJ cord-010119-t1x9gknd 4529 45 leukapheresis leukapheresis NN cord-010119-t1x9gknd 4529 46 ( ( -LRB- cord-010119-t1x9gknd 4529 47 3.9 3.9 CD cord-010119-t1x9gknd 4529 48 % % NN cord-010119-t1x9gknd 4529 49 ) ) -RRB- cord-010119-t1x9gknd 4529 50 . . . cord-010119-t1x9gknd 4530 1 COBE COBE NNP cord-010119-t1x9gknd 4530 2 Spectra Spectra NNP cord-010119-t1x9gknd 4530 3 ( ( -LRB- cord-010119-t1x9gknd 4530 4 37.4 37.4 CD cord-010119-t1x9gknd 4530 5 % % NN cord-010119-t1x9gknd 4530 6 ) ) -RRB- cord-010119-t1x9gknd 4530 7 and and CC cord-010119-t1x9gknd 4530 8 Amicus Amicus NNP cord-010119-t1x9gknd 4530 9 ( ( -LRB- cord-010119-t1x9gknd 4530 10 16.8 16.8 CD cord-010119-t1x9gknd 4530 11 % % NN cord-010119-t1x9gknd 4530 12 ) ) -RRB- cord-010119-t1x9gknd 4530 13 were be VBD cord-010119-t1x9gknd 4530 14 the the DT cord-010119-t1x9gknd 4530 15 most most RBS cord-010119-t1x9gknd 4530 16 widely widely RB cord-010119-t1x9gknd 4530 17 distributed distribute VBN cord-010119-t1x9gknd 4530 18 instruments instrument NNS cord-010119-t1x9gknd 4530 19 . . . cord-010119-t1x9gknd 4531 1 Centrifugation Centrifugation NNP cord-010119-t1x9gknd 4531 2 was be VBD cord-010119-t1x9gknd 4531 3 the the DT cord-010119-t1x9gknd 4531 4 dominant dominant JJ cord-010119-t1x9gknd 4531 5 technique technique NN cord-010119-t1x9gknd 4531 6 ( ( -LRB- cord-010119-t1x9gknd 4531 7 92.2 92.2 CD cord-010119-t1x9gknd 4531 8 % % NN cord-010119-t1x9gknd 4531 9 ) ) -RRB- cord-010119-t1x9gknd 4531 10 for for IN cord-010119-t1x9gknd 4531 11 therapeutic therapeutic JJ cord-010119-t1x9gknd 4531 12 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 4531 13 . . . cord-010119-t1x9gknd 4532 1 Detailed detailed JJ cord-010119-t1x9gknd 4532 2 information information NN cord-010119-t1x9gknd 4532 3 was be VBD cord-010119-t1x9gknd 4532 4 given give VBN cord-010119-t1x9gknd 4532 5 for for IN cord-010119-t1x9gknd 4532 6 4,199 4,199 CD cord-010119-t1x9gknd 4532 7 therapeutic therapeutic JJ cord-010119-t1x9gknd 4532 8 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 4532 9 procedures procedure NNS cord-010119-t1x9gknd 4532 10 performed perform VBN cord-010119-t1x9gknd 4532 11 on on IN cord-010119-t1x9gknd 4532 12 786 786 CD cord-010119-t1x9gknd 4532 13 patients patient NNS cord-010119-t1x9gknd 4532 14 ( ( -LRB- cord-010119-t1x9gknd 4532 15 some some DT cord-010119-t1x9gknd 4532 16 items item NNS cord-010119-t1x9gknd 4532 17 were be VBD cord-010119-t1x9gknd 4532 18 not not RB cord-010119-t1x9gknd 4532 19 completely completely RB cord-010119-t1x9gknd 4532 20 filled fill VBN cord-010119-t1x9gknd 4532 21 out out RP cord-010119-t1x9gknd 4532 22 ) ) -RRB- cord-010119-t1x9gknd 4532 23 . . . cord-010119-t1x9gknd 4533 1 Spectra Spectra NNP cord-010119-t1x9gknd 4533 2 Optia Optia NNP cord-010119-t1x9gknd 4533 3 ( ( -LRB- cord-010119-t1x9gknd 4533 4 42.7 42.7 CD cord-010119-t1x9gknd 4533 5 % % NN cord-010119-t1x9gknd 4533 6 ) ) -RRB- cord-010119-t1x9gknd 4533 7 and and CC cord-010119-t1x9gknd 4533 8 COBE COBE NNP cord-010119-t1x9gknd 4533 9 Spectra Spectra NNP cord-010119-t1x9gknd 4533 10 ( ( -LRB- cord-010119-t1x9gknd 4533 11 26.6 26.6 CD cord-010119-t1x9gknd 4533 12 % % NN cord-010119-t1x9gknd 4533 13 ) ) -RRB- cord-010119-t1x9gknd 4533 14 were be VBD cord-010119-t1x9gknd 4533 15 the the DT cord-010119-t1x9gknd 4533 16 most most RBS cord-010119-t1x9gknd 4533 17 frequently frequently RB cord-010119-t1x9gknd 4533 18 used use VBN cord-010119-t1x9gknd 4533 19 instruments instrument NNS cord-010119-t1x9gknd 4533 20 for for IN cord-010119-t1x9gknd 4533 21 therapeutic therapeutic JJ cord-010119-t1x9gknd 4533 22 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 4533 23 . . . cord-010119-t1x9gknd 4534 1 Fresh fresh JJ cord-010119-t1x9gknd 4534 2 frozen frozen JJ cord-010119-t1x9gknd 4534 3 plasma plasma NN cord-010119-t1x9gknd 4534 4 ( ( -LRB- cord-010119-t1x9gknd 4534 5 FFP FFP NNP cord-010119-t1x9gknd 4534 6 ) ) -RRB- cord-010119-t1x9gknd 4534 7 was be VBD cord-010119-t1x9gknd 4534 8 used use VBN cord-010119-t1x9gknd 4534 9 most most RBS cord-010119-t1x9gknd 4534 10 frequently frequently RB cord-010119-t1x9gknd 4534 11 ( ( -LRB- cord-010119-t1x9gknd 4534 12 47.2 47.2 CD cord-010119-t1x9gknd 4534 13 % % NN cord-010119-t1x9gknd 4534 14 ) ) -RRB- cord-010119-t1x9gknd 4534 15 as as IN cord-010119-t1x9gknd 4534 16 the the DT cord-010119-t1x9gknd 4534 17 replacement replacement NN cord-010119-t1x9gknd 4534 18 fluid fluid NN cord-010119-t1x9gknd 4534 19 followed follow VBD cord-010119-t1x9gknd 4534 20 by by IN cord-010119-t1x9gknd 4534 21 5 5 CD cord-010119-t1x9gknd 4534 22 % % NN cord-010119-t1x9gknd 4534 23 albumin albumin NN cord-010119-t1x9gknd 4534 24 ( ( -LRB- cord-010119-t1x9gknd 4534 25 26.3 26.3 CD cord-010119-t1x9gknd 4534 26 % % NN cord-010119-t1x9gknd 4534 27 ) ) -RRB- cord-010119-t1x9gknd 4534 28 , , , cord-010119-t1x9gknd 4534 29 4 4 CD cord-010119-t1x9gknd 4534 30 % % NN cord-010119-t1x9gknd 4534 31 albumin albumin NN cord-010119-t1x9gknd 4534 32 ( ( -LRB- cord-010119-t1x9gknd 4534 33 13.3 13.3 CD cord-010119-t1x9gknd 4534 34 % % NN cord-010119-t1x9gknd 4534 35 ) ) -RRB- cord-010119-t1x9gknd 4534 36 , , , cord-010119-t1x9gknd 4534 37 and and CC cord-010119-t1x9gknd 4534 38 5 5 CD cord-010119-t1x9gknd 4534 39 % % NN cord-010119-t1x9gknd 4534 40 albumin albumin NN cord-010119-t1x9gknd 4534 41 1 1 CD cord-010119-t1x9gknd 4534 42 FFP FFP NNP cord-010119-t1x9gknd 4534 43 ( ( -LRB- cord-010119-t1x9gknd 4534 44 11.1 11.1 CD cord-010119-t1x9gknd 4534 45 % % NN cord-010119-t1x9gknd 4534 46 ) ) -RRB- cord-010119-t1x9gknd 4534 47 . . . cord-010119-t1x9gknd 4535 1 Most Most JJS cord-010119-t1x9gknd 4535 2 of of IN cord-010119-t1x9gknd 4535 3 the the DT cord-010119-t1x9gknd 4535 4 procedures procedure NNS cord-010119-t1x9gknd 4535 5 were be VBD cord-010119-t1x9gknd 4535 6 performed perform VBN cord-010119-t1x9gknd 4535 7 for for IN cord-010119-t1x9gknd 4535 8 1 1 CD cord-010119-t1x9gknd 4535 9 plasma plasma NN cord-010119-t1x9gknd 4535 10 volume volume NN cord-010119-t1x9gknd 4535 11 ( ( -LRB- cord-010119-t1x9gknd 4535 12 72.4 72.4 CD cord-010119-t1x9gknd 4535 13 % % NN cord-010119-t1x9gknd 4535 14 ) ) -RRB- cord-010119-t1x9gknd 4535 15 . . . cord-010119-t1x9gknd 4536 1 ACD ACD NNP cord-010119-t1x9gknd 4536 2 ( ( -LRB- cord-010119-t1x9gknd 4536 3 88.4 88.4 CD cord-010119-t1x9gknd 4536 4 % % NN cord-010119-t1x9gknd 4536 5 ) ) -RRB- cord-010119-t1x9gknd 4536 6 and and CC cord-010119-t1x9gknd 4536 7 heparin heparin NN cord-010119-t1x9gknd 4536 8 ( ( -LRB- cord-010119-t1x9gknd 4536 9 11.5 11.5 CD cord-010119-t1x9gknd 4536 10 % % NN cord-010119-t1x9gknd 4536 11 ) ) -RRB- cord-010119-t1x9gknd 4536 12 were be VBD cord-010119-t1x9gknd 4536 13 used use VBN cord-010119-t1x9gknd 4536 14 for for IN cord-010119-t1x9gknd 4536 15 anticoagulation anticoagulation NN cord-010119-t1x9gknd 4536 16 . . . cord-010119-t1x9gknd 4537 1 Central central JJ cord-010119-t1x9gknd 4537 2 venous venous JJ cord-010119-t1x9gknd 4537 3 catheter catheter NN cord-010119-t1x9gknd 4537 4 ( ( -LRB- cord-010119-t1x9gknd 4537 5 91.9 91.9 CD cord-010119-t1x9gknd 4537 6 % % NN cord-010119-t1x9gknd 4537 7 ) ) -RRB- cord-010119-t1x9gknd 4537 8 was be VBD cord-010119-t1x9gknd 4537 9 the the DT cord-010119-t1x9gknd 4537 10 dominant dominant JJ cord-010119-t1x9gknd 4537 11 type type NN cord-010119-t1x9gknd 4537 12 of of IN cord-010119-t1x9gknd 4537 13 vascular vascular JJ cord-010119-t1x9gknd 4537 14 access access NN cord-010119-t1x9gknd 4537 15 . . . cord-010119-t1x9gknd 4538 1 Major major JJ cord-010119-t1x9gknd 4538 2 clinical clinical JJ cord-010119-t1x9gknd 4538 3 indications indication NNS cord-010119-t1x9gknd 4538 4 were be VBD cord-010119-t1x9gknd 4538 5 desensitization desensitization NN cord-010119-t1x9gknd 4538 6 for for IN cord-010119-t1x9gknd 4538 7 ABO ABO NNP cord-010119-t1x9gknd 4538 8 incompatible incompatible JJ cord-010119-t1x9gknd 4538 9 renal renal JJ cord-010119-t1x9gknd 4538 10 transplantation transplantation NN cord-010119-t1x9gknd 4538 11 ( ( -LRB- cord-010119-t1x9gknd 4538 12 24.1 24.1 CD cord-010119-t1x9gknd 4538 13 % % NN cord-010119-t1x9gknd 4538 14 ) ) -RRB- cord-010119-t1x9gknd 4538 15 , , , cord-010119-t1x9gknd 4538 16 antibody antibody NN cord-010119-t1x9gknd 4538 17 mediated mediate VBN cord-010119-t1x9gknd 4538 18 rejection rejection NN cord-010119-t1x9gknd 4538 19 in in IN cord-010119-t1x9gknd 4538 20 renal renal JJ cord-010119-t1x9gknd 4538 21 transplantation transplantation NN cord-010119-t1x9gknd 4538 22 ( ( -LRB- cord-010119-t1x9gknd 4538 23 19.9 19.9 CD cord-010119-t1x9gknd 4538 24 % % NN cord-010119-t1x9gknd 4538 25 ) ) -RRB- cord-010119-t1x9gknd 4538 26 , , , cord-010119-t1x9gknd 4538 27 thrombotic thrombotic JJ cord-010119-t1x9gknd 4538 28 microangiopathy microangiopathy NNP cord-010119-t1x9gknd 4538 29 ( ( -LRB- cord-010119-t1x9gknd 4538 30 11.5 11.5 CD cord-010119-t1x9gknd 4538 31 % % NN cord-010119-t1x9gknd 4538 32 ) ) -RRB- cord-010119-t1x9gknd 4538 33 , , , cord-010119-t1x9gknd 4538 34 desensitization desensitization NN cord-010119-t1x9gknd 4538 35 for for IN cord-010119-t1x9gknd 4538 36 ABO ABO NNP cord-010119-t1x9gknd 4538 37 compatible compatible JJ cord-010119-t1x9gknd 4538 38 renal renal JJ cord-010119-t1x9gknd 4538 39 transplantation transplantation NN cord-010119-t1x9gknd 4538 40 ( ( -LRB- cord-010119-t1x9gknd 4538 41 4.7 4.7 CD cord-010119-t1x9gknd 4538 42 % % NN cord-010119-t1x9gknd 4538 43 ) ) -RRB- cord-010119-t1x9gknd 4538 44 , , , cord-010119-t1x9gknd 4538 45 neuromyelitis neuromyelitis NNP cord-010119-t1x9gknd 4538 46 optica optica NNP cord-010119-t1x9gknd 4538 47 spectrum spectrum NNP cord-010119-t1x9gknd 4538 48 disorders disorder NNS cord-010119-t1x9gknd 4538 49 ( ( -LRB- cord-010119-t1x9gknd 4538 50 4.6 4.6 CD cord-010119-t1x9gknd 4538 51 % % NN cord-010119-t1x9gknd 4538 52 ) ) -RRB- cord-010119-t1x9gknd 4538 53 , , , cord-010119-t1x9gknd 4538 54 and and CC cord-010119-t1x9gknd 4538 55 hyperviscosity hyperviscosity NN cord-010119-t1x9gknd 4538 56 in in IN cord-010119-t1x9gknd 4538 57 monoclonal monoclonal JJ cord-010119-t1x9gknd 4538 58 gammopathies gammopathy NNS cord-010119-t1x9gknd 4538 59 ( ( -LRB- cord-010119-t1x9gknd 4538 60 4.6 4.6 CD cord-010119-t1x9gknd 4538 61 % % NN cord-010119-t1x9gknd 4538 62 ) ) -RRB- cord-010119-t1x9gknd 4538 63 . . . cord-010119-t1x9gknd 4539 1 Adverse adverse JJ cord-010119-t1x9gknd 4539 2 reactions reaction NNS cord-010119-t1x9gknd 4539 3 were be VBD cord-010119-t1x9gknd 4539 4 observed observe VBN cord-010119-t1x9gknd 4539 5 in in IN cord-010119-t1x9gknd 4539 6 8.5 8.5 CD cord-010119-t1x9gknd 4539 7 % % NN cord-010119-t1x9gknd 4539 8 of of IN cord-010119-t1x9gknd 4539 9 the the DT cord-010119-t1x9gknd 4539 10 procedures procedure NNS cord-010119-t1x9gknd 4539 11 . . . cord-010119-t1x9gknd 4540 1 Allergic allergic JJ cord-010119-t1x9gknd 4540 2 reaction reaction NN cord-010119-t1x9gknd 4540 3 ( ( -LRB- cord-010119-t1x9gknd 4540 4 55.2 55.2 CD cord-010119-t1x9gknd 4540 5 % % NN cord-010119-t1x9gknd 4540 6 ) ) -RRB- cord-010119-t1x9gknd 4540 7 , , , cord-010119-t1x9gknd 4540 8 hypocalcemic hypocalcemic JJ cord-010119-t1x9gknd 4540 9 symptom symptom NN cord-010119-t1x9gknd 4540 10 ( ( -LRB- cord-010119-t1x9gknd 4540 11 20.4 20.4 CD cord-010119-t1x9gknd 4540 12 % % NN cord-010119-t1x9gknd 4540 13 ) ) -RRB- cord-010119-t1x9gknd 4540 14 , , , cord-010119-t1x9gknd 4540 15 and and CC cord-010119-t1x9gknd 4540 16 hypotension hypotension NN cord-010119-t1x9gknd 4540 17 ( ( -LRB- cord-010119-t1x9gknd 4540 18 6.9 6.9 CD cord-010119-t1x9gknd 4540 19 % % NN cord-010119-t1x9gknd 4540 20 ) ) -RRB- cord-010119-t1x9gknd 4540 21 were be VBD cord-010119-t1x9gknd 4540 22 frequently frequently RB cord-010119-t1x9gknd 4540 23 reported report VBN cord-010119-t1x9gknd 4540 24 . . . cord-010119-t1x9gknd 4541 1 Therapeutic therapeutic JJ cord-010119-t1x9gknd 4541 2 effect effect NN cord-010119-t1x9gknd 4541 3 was be VBD cord-010119-t1x9gknd 4541 4 achieved achieve VBN cord-010119-t1x9gknd 4541 5 in in IN cord-010119-t1x9gknd 4541 6 86.5 86.5 CD cord-010119-t1x9gknd 4541 7 % % NN cord-010119-t1x9gknd 4541 8 of of IN cord-010119-t1x9gknd 4541 9 the the DT cord-010119-t1x9gknd 4541 10 patients patient NNS cord-010119-t1x9gknd 4541 11 . . . cord-010119-t1x9gknd 4542 1 Our -PRON- PRP$ cord-010119-t1x9gknd 4542 2 apheresis apheresis NN cord-010119-t1x9gknd 4542 3 registry registry NN cord-010119-t1x9gknd 4542 4 has have VBZ cord-010119-t1x9gknd 4542 5 been be VBN cord-010119-t1x9gknd 4542 6 well well RB cord-010119-t1x9gknd 4542 7 run run VBN cord-010119-t1x9gknd 4542 8 for for IN cord-010119-t1x9gknd 4542 9 10 10 CD cord-010119-t1x9gknd 4542 10 years year NNS cord-010119-t1x9gknd 4542 11 . . . cord-010119-t1x9gknd 4543 1 Recent recent JJ cord-010119-t1x9gknd 4543 2 data datum NNS cord-010119-t1x9gknd 4543 3 reflects reflect VBZ cord-010119-t1x9gknd 4543 4 the the DT cord-010119-t1x9gknd 4543 5 increase increase NN cord-010119-t1x9gknd 4543 6 of of IN cord-010119-t1x9gknd 4543 7 ABO ABO NNP cord-010119-t1x9gknd 4543 8 incompatible incompatible JJ cord-010119-t1x9gknd 4543 9 transplantation transplantation NN cord-010119-t1x9gknd 4543 10 in in IN cord-010119-t1x9gknd 4543 11 Korea Korea NNP cord-010119-t1x9gknd 4543 12 . . . cord-010119-t1x9gknd 4544 1 Revision revision NN cord-010119-t1x9gknd 4544 2 and and CC cord-010119-t1x9gknd 4544 3 update update NN cord-010119-t1x9gknd 4544 4 of of IN cord-010119-t1x9gknd 4544 5 the the DT cord-010119-t1x9gknd 4544 6 registry registry NN cord-010119-t1x9gknd 4544 7 planned plan VBN cord-010119-t1x9gknd 4544 8 this this DT cord-010119-t1x9gknd 4544 9 year year NN cord-010119-t1x9gknd 4544 10 will will MD cord-010119-t1x9gknd 4544 11 help help VB cord-010119-t1x9gknd 4544 12 us -PRON- PRP cord-010119-t1x9gknd 4544 13 achieve achieve VB cord-010119-t1x9gknd 4544 14 better well JJR cord-010119-t1x9gknd 4544 15 understanding understanding NN cord-010119-t1x9gknd 4544 16 on on IN cord-010119-t1x9gknd 4544 17 the the DT cord-010119-t1x9gknd 4544 18 apheresis apheresis NN cord-010119-t1x9gknd 4544 19 status status NN cord-010119-t1x9gknd 4544 20 of of IN cord-010119-t1x9gknd 4544 21 our -PRON- PRP$ cord-010119-t1x9gknd 4544 22 region region NN cord-010119-t1x9gknd 4544 23 . . . cord-010119-t1x9gknd 4545 1 Plasma Plasma NNP cord-010119-t1x9gknd 4545 2 Exchange Exchange NNP cord-010119-t1x9gknd 4545 3 May May MD cord-010119-t1x9gknd 4545 4 Not not RB cord-010119-t1x9gknd 4545 5 Always always RB cord-010119-t1x9gknd 4545 6 be be VB cord-010119-t1x9gknd 4545 7 Necessary necessary JJ cord-010119-t1x9gknd 4545 8 in in IN cord-010119-t1x9gknd 4545 9 Patients patient NNS cord-010119-t1x9gknd 4545 10 with with IN cord-010119-t1x9gknd 4545 11 Severe severe JJ cord-010119-t1x9gknd 4545 12 Hypertriglyceridemia Hypertriglyceridemia NNP cord-010119-t1x9gknd 4545 13 and and CC cord-010119-t1x9gknd 4545 14 Acute Acute NNP cord-010119-t1x9gknd 4545 15 Pancreatitis Pancreatitis NNP cord-010119-t1x9gknd 4545 16 . . . cord-010119-t1x9gknd 4546 1 Jan Jan NNP cord-010119-t1x9gknd 4546 2 C C NNP cord-010119-t1x9gknd 4546 3 Hofmann Hofmann NNP cord-010119-t1x9gknd 4546 4 * * NFP cord-010119-t1x9gknd 4546 5 and and CC cord-010119-t1x9gknd 4546 6 Dobri Dobri NNP cord-010119-t1x9gknd 4546 7 D D NNP cord-010119-t1x9gknd 4546 8 Kiprov Kiprov NNP cord-010119-t1x9gknd 4546 9 . . . cord-010119-t1x9gknd 4547 1 California California NNP cord-010119-t1x9gknd 4547 2 Pacific Pacific NNP cord-010119-t1x9gknd 4547 3 Medical Medical NNP cord-010119-t1x9gknd 4547 4 Center Center NNP cord-010119-t1x9gknd 4547 5 Background Background NNP cord-010119-t1x9gknd 4547 6 / / SYM cord-010119-t1x9gknd 4547 7 Case Case NNP cord-010119-t1x9gknd 4547 8 Studies Studies NNPS cord-010119-t1x9gknd 4547 9 : : : cord-010119-t1x9gknd 4548 1 Hypertriglyceridemic Hypertriglyceridemic NNP cord-010119-t1x9gknd 4548 2 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4548 3 ( ( -LRB- cord-010119-t1x9gknd 4548 4 HP HP NNP cord-010119-t1x9gknd 4548 5 ) ) -RRB- cord-010119-t1x9gknd 4548 6 is be VBZ cord-010119-t1x9gknd 4548 7 characterized characterize VBN cord-010119-t1x9gknd 4548 8 by by IN cord-010119-t1x9gknd 4548 9 severe severe JJ cord-010119-t1x9gknd 4548 10 hypertriglyceridemia hypertriglyceridemia NN cord-010119-t1x9gknd 4548 11 ( ( -LRB- cord-010119-t1x9gknd 4548 12 sHTG sHTG NNP cord-010119-t1x9gknd 4548 13 : : : cord-010119-t1x9gknd 4549 1 triglyceride triglyceride NN cord-010119-t1x9gknd 4549 2 > > SYM cord-010119-t1x9gknd 4549 3 1000 1000 CD cord-010119-t1x9gknd 4549 4 - - SYM cord-010119-t1x9gknd 4549 5 2000 2000 CD cord-010119-t1x9gknd 4549 6 mg mg NNP cord-010119-t1x9gknd 4549 7 / / SYM cord-010119-t1x9gknd 4549 8 dl dl NNP cord-010119-t1x9gknd 4549 9 ) ) -RRB- cord-010119-t1x9gknd 4549 10 , , , cord-010119-t1x9gknd 4549 11 acute acute JJ cord-010119-t1x9gknd 4549 12 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4549 13 ( ( -LRB- cord-010119-t1x9gknd 4549 14 AP AP NNP cord-010119-t1x9gknd 4549 15 ) ) -RRB- cord-010119-t1x9gknd 4549 16 , , , cord-010119-t1x9gknd 4549 17 and and CC cord-010119-t1x9gknd 4549 18 absence absence NN cord-010119-t1x9gknd 4549 19 of of IN cord-010119-t1x9gknd 4549 20 other other JJ cord-010119-t1x9gknd 4549 21 causes cause NNS cord-010119-t1x9gknd 4549 22 . . . cord-010119-t1x9gknd 4550 1 HP HP NNP cord-010119-t1x9gknd 4550 2 is be VBZ cord-010119-t1x9gknd 4550 3 a a DT cord-010119-t1x9gknd 4550 4 potentially potentially RB cord-010119-t1x9gknd 4550 5 fatal fatal JJ cord-010119-t1x9gknd 4550 6 complication complication NN cord-010119-t1x9gknd 4550 7 of of IN cord-010119-t1x9gknd 4550 8 acute acute JJ cord-010119-t1x9gknd 4550 9 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4550 10 with with IN cord-010119-t1x9gknd 4550 11 an an DT cord-010119-t1x9gknd 4550 12 incidence incidence NN cord-010119-t1x9gknd 4550 13 of of IN cord-010119-t1x9gknd 4550 14 $ $ $ cord-010119-t1x9gknd 4550 15 18 18 CD cord-010119-t1x9gknd 4550 16 deaths/100,000 deaths/100,000 NN cord-010119-t1x9gknd 4550 17 cases case NNS cord-010119-t1x9gknd 4550 18 / / SYM cord-010119-t1x9gknd 4550 19 year year NN cord-010119-t1x9gknd 4550 20 . . . cord-010119-t1x9gknd 4551 1 Complications complication NNS cord-010119-t1x9gknd 4551 2 of of IN cord-010119-t1x9gknd 4551 3 sHTG shtg NN cord-010119-t1x9gknd 4551 4 include include VBP cord-010119-t1x9gknd 4551 5 : : : cord-010119-t1x9gknd 4551 6 abdominal abdominal JJ cord-010119-t1x9gknd 4551 7 pain pain NN cord-010119-t1x9gknd 4551 8 ( ( -LRB- cord-010119-t1x9gknd 4551 9 nausea nausea NN cord-010119-t1x9gknd 4551 10 / / SYM cord-010119-t1x9gknd 4551 11 vomiting vomiting NN cord-010119-t1x9gknd 4551 12 ) ) -RRB- cord-010119-t1x9gknd 4551 13 , , , cord-010119-t1x9gknd 4551 14 acute acute JJ cord-010119-t1x9gknd 4551 15 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4551 16 , , , cord-010119-t1x9gknd 4551 17 hepatosplenomegaly hepatosplenomegaly NNP cord-010119-t1x9gknd 4551 18 , , , cord-010119-t1x9gknd 4551 19 eruptive eruptive JJ cord-010119-t1x9gknd 4551 20 xanthomas xanthomas NNP cord-010119-t1x9gknd 4551 21 , , , cord-010119-t1x9gknd 4551 22 lipemia lipemia NNP cord-010119-t1x9gknd 4551 23 retinalis retinalis NNP cord-010119-t1x9gknd 4551 24 , , , cord-010119-t1x9gknd 4551 25 memory memory NN cord-010119-t1x9gknd 4551 26 loss loss NN cord-010119-t1x9gknd 4551 27 , , , cord-010119-t1x9gknd 4551 28 dementia dementia NN cord-010119-t1x9gknd 4551 29 , , , cord-010119-t1x9gknd 4551 30 and and CC cord-010119-t1x9gknd 4551 31 peripheral peripheral JJ cord-010119-t1x9gknd 4551 32 neuropathy neuropathy NN cord-010119-t1x9gknd 4551 33 . . . cord-010119-t1x9gknd 4552 1 We -PRON- PRP cord-010119-t1x9gknd 4552 2 report report VBP cord-010119-t1x9gknd 4552 3 on on IN cord-010119-t1x9gknd 4552 4 the the DT cord-010119-t1x9gknd 4552 5 effective effective JJ cord-010119-t1x9gknd 4552 6 use use NN cord-010119-t1x9gknd 4552 7 of of IN cord-010119-t1x9gknd 4552 8 plasma plasma NN cord-010119-t1x9gknd 4552 9 exchange exchange NN cord-010119-t1x9gknd 4552 10 ( ( -LRB- cord-010119-t1x9gknd 4552 11 PE PE NNP cord-010119-t1x9gknd 4552 12 ) ) -RRB- cord-010119-t1x9gknd 4552 13 to to TO cord-010119-t1x9gknd 4552 14 treat treat VB cord-010119-t1x9gknd 4552 15 patients patient NNS cord-010119-t1x9gknd 4552 16 ( ( -LRB- cord-010119-t1x9gknd 4552 17 pts pt NNS cord-010119-t1x9gknd 4552 18 ) ) -RRB- cord-010119-t1x9gknd 4552 19 with with IN cord-010119-t1x9gknd 4552 20 HP HP NNP cord-010119-t1x9gknd 4552 21 refractory refractory JJ cord-010119-t1x9gknd 4552 22 to to IN cord-010119-t1x9gknd 4552 23 conventional conventional JJ cord-010119-t1x9gknd 4552 24 medical medical JJ cord-010119-t1x9gknd 4552 25 therapy therapy NN cord-010119-t1x9gknd 4553 1 ( ( -LRB- cord-010119-t1x9gknd 4553 2 lipid lipid NN cord-010119-t1x9gknd 4553 3 - - HYPH cord-010119-t1x9gknd 4553 4 free free JJ cord-010119-t1x9gknd 4553 5 diet diet NN cord-010119-t1x9gknd 4553 6 plus plus CC cord-010119-t1x9gknd 4553 7 pharmaceutical pharmaceutical JJ cord-010119-t1x9gknd 4553 8 interventions intervention NNS cord-010119-t1x9gknd 4553 9 ) ) -RRB- cord-010119-t1x9gknd 4553 10 . . . cord-010119-t1x9gknd 4554 1 Study Study NNP cord-010119-t1x9gknd 4554 2 Design Design NNP cord-010119-t1x9gknd 4554 3 / / SYM cord-010119-t1x9gknd 4554 4 Method method NN cord-010119-t1x9gknd 4554 5 : : : cord-010119-t1x9gknd 4554 6 We -PRON- PRP cord-010119-t1x9gknd 4554 7 reviewed review VBD cord-010119-t1x9gknd 4554 8 the the DT cord-010119-t1x9gknd 4554 9 medical medical JJ cord-010119-t1x9gknd 4554 10 records record NNS cord-010119-t1x9gknd 4554 11 of of IN cord-010119-t1x9gknd 4554 12 41 41 CD cord-010119-t1x9gknd 4554 13 pts pt NNS cord-010119-t1x9gknd 4554 14 who who WP cord-010119-t1x9gknd 4554 15 were be VBD cord-010119-t1x9gknd 4554 16 diagnosed diagnose VBN cord-010119-t1x9gknd 4554 17 with with IN cord-010119-t1x9gknd 4554 18 HP HP NNP cord-010119-t1x9gknd 4554 19 from from IN cord-010119-t1x9gknd 4554 20 January January NNP cord-010119-t1x9gknd 4554 21 , , , cord-010119-t1x9gknd 4554 22 2009 2009 CD cord-010119-t1x9gknd 4554 23 through through IN cord-010119-t1x9gknd 4554 24 January January NNP cord-010119-t1x9gknd 4554 25 , , , cord-010119-t1x9gknd 4554 26 2017 2017 CD cord-010119-t1x9gknd 4554 27 , , , cord-010119-t1x9gknd 4554 28 and and CC cord-010119-t1x9gknd 4554 29 referred refer VBD cord-010119-t1x9gknd 4554 30 for for IN cord-010119-t1x9gknd 4554 31 immunotherapy immunotherapy NN cord-010119-t1x9gknd 4554 32 evaluation evaluation NN cord-010119-t1x9gknd 4554 33 . . . cord-010119-t1x9gknd 4555 1 27/41 27/41 CD cord-010119-t1x9gknd 4556 1 ( ( -LRB- cord-010119-t1x9gknd 4556 2 66 66 CD cord-010119-t1x9gknd 4556 3 % % NN cord-010119-t1x9gknd 4556 4 ) ) -RRB- cord-010119-t1x9gknd 4556 5 pts pt NNS cord-010119-t1x9gknd 4556 6 received receive VBD cord-010119-t1x9gknd 4556 7 conventional conventional JJ cord-010119-t1x9gknd 4556 8 therapy therapy NN cord-010119-t1x9gknd 4556 9 ( ( -LRB- cord-010119-t1x9gknd 4556 10 CT CT NNP cord-010119-t1x9gknd 4556 11 ) ) -RRB- cord-010119-t1x9gknd 4556 12 and and CC cord-010119-t1x9gknd 4556 13 PE PE NNP cord-010119-t1x9gknd 4556 14 ( ( -LRB- cord-010119-t1x9gknd 4556 15 PE PE NNP cord-010119-t1x9gknd 4556 16 group group NN cord-010119-t1x9gknd 4556 17 ) ) -RRB- cord-010119-t1x9gknd 4556 18 , , , cord-010119-t1x9gknd 4556 19 and and CC cord-010119-t1x9gknd 4556 20 14/41 14/41 CD cord-010119-t1x9gknd 4556 21 ( ( -LRB- cord-010119-t1x9gknd 4556 22 34 34 CD cord-010119-t1x9gknd 4556 23 % % NN cord-010119-t1x9gknd 4556 24 ) ) -RRB- cord-010119-t1x9gknd 4556 25 pts pt NNS cord-010119-t1x9gknd 4556 26 received receive VBD cord-010119-t1x9gknd 4556 27 CT CT NNP cord-010119-t1x9gknd 4556 28 alone alone JJ cord-010119-t1x9gknd 4556 29 ( ( -LRB- cord-010119-t1x9gknd 4556 30 CT CT NNP cord-010119-t1x9gknd 4556 31 group group NN cord-010119-t1x9gknd 4556 32 ) ) -RRB- cord-010119-t1x9gknd 4556 33 . . . cord-010119-t1x9gknd 4557 1 Mean mean JJ cord-010119-t1x9gknd 4557 2 age age NN cord-010119-t1x9gknd 4557 3 was be VBD cord-010119-t1x9gknd 4557 4 36 36 CD cord-010119-t1x9gknd 4557 5 years year NNS cord-010119-t1x9gknd 4558 1 ( ( -LRB- cord-010119-t1x9gknd 4558 2 range range NNP cord-010119-t1x9gknd 4558 3 16 16 CD cord-010119-t1x9gknd 4558 4 - - SYM cord-010119-t1x9gknd 4558 5 79 79 CD cord-010119-t1x9gknd 4558 6 ) ) -RRB- cord-010119-t1x9gknd 4558 7 , , , cord-010119-t1x9gknd 4558 8 and and CC cord-010119-t1x9gknd 4558 9 56 56 CD cord-010119-t1x9gknd 4558 10 % % NN cord-010119-t1x9gknd 4558 11 were be VBD cord-010119-t1x9gknd 4558 12 female female JJ cord-010119-t1x9gknd 4558 13 . . . cord-010119-t1x9gknd 4559 1 Baseline baseline JJ cord-010119-t1x9gknd 4559 2 mean mean JJ cord-010119-t1x9gknd 4559 3 triglyceride triglyceride NN cord-010119-t1x9gknd 4559 4 level level NN cord-010119-t1x9gknd 4559 5 ( ( -LRB- cord-010119-t1x9gknd 4559 6 normal normal JJ cord-010119-t1x9gknd 4559 7 < < XX cord-010119-t1x9gknd 4559 8 150 150 CD cord-010119-t1x9gknd 4559 9 mg mg NNP cord-010119-t1x9gknd 4559 10 / / SYM cord-010119-t1x9gknd 4559 11 dl dl NNP cord-010119-t1x9gknd 4559 12 ) ) -RRB- cord-010119-t1x9gknd 4559 13 for for IN cord-010119-t1x9gknd 4559 14 PE PE NNP cord-010119-t1x9gknd 4559 15 group group NN cord-010119-t1x9gknd 4559 16 was be VBD cord-010119-t1x9gknd 4559 17 6,728 6,728 CD cord-010119-t1x9gknd 4559 18 mg mg NNP cord-010119-t1x9gknd 4559 19 / / SYM cord-010119-t1x9gknd 4559 20 dl dl NNP cord-010119-t1x9gknd 4559 21 ( ( -LRB- cord-010119-t1x9gknd 4559 22 4,652 4,652 CD cord-010119-t1x9gknd 4559 23 - - SYM cord-010119-t1x9gknd 4559 24 12,486 12,486 CD cord-010119-t1x9gknd 4559 25 ) ) -RRB- cord-010119-t1x9gknd 4559 26 versus versus IN cord-010119-t1x9gknd 4559 27 3,142 3,142 CD cord-010119-t1x9gknd 4559 28 mg mg NNP cord-010119-t1x9gknd 4559 29 / / SYM cord-010119-t1x9gknd 4559 30 dl dl NNP cord-010119-t1x9gknd 4559 31 ( ( -LRB- cord-010119-t1x9gknd 4559 32 1,697 1,697 CD cord-010119-t1x9gknd 4559 33 - - SYM cord-010119-t1x9gknd 4559 34 5,120 5,120 CD cord-010119-t1x9gknd 4559 35 ) ) -RRB- cord-010119-t1x9gknd 4559 36 for for IN cord-010119-t1x9gknd 4559 37 CT CT NNP cord-010119-t1x9gknd 4559 38 group group NN cord-010119-t1x9gknd 4559 39 . . . cord-010119-t1x9gknd 4560 1 Baseline baseline JJ cord-010119-t1x9gknd 4560 2 mean mean JJ cord-010119-t1x9gknd 4560 3 lipase lipase NN cord-010119-t1x9gknd 4560 4 level level NN cord-010119-t1x9gknd 4560 5 ( ( -LRB- cord-010119-t1x9gknd 4560 6 normal normal JJ cord-010119-t1x9gknd 4560 7 < < XX cord-010119-t1x9gknd 4560 8 393 393 CD cord-010119-t1x9gknd 4560 9 U U NNP cord-010119-t1x9gknd 4560 10 / / SYM cord-010119-t1x9gknd 4560 11 L L NNP cord-010119-t1x9gknd 4560 12 ) ) -RRB- cord-010119-t1x9gknd 4560 13 for for IN cord-010119-t1x9gknd 4560 14 PE PE NNP cord-010119-t1x9gknd 4560 15 group group NN cord-010119-t1x9gknd 4560 16 was be VBD cord-010119-t1x9gknd 4560 17 1,798 1,798 CD cord-010119-t1x9gknd 4560 18 U U NNP cord-010119-t1x9gknd 4560 19 / / SYM cord-010119-t1x9gknd 4560 20 L L NNP cord-010119-t1x9gknd 4560 21 ( ( -LRB- cord-010119-t1x9gknd 4560 22 797 797 CD cord-010119-t1x9gknd 4560 23 - - HYPH cord-010119-t1x9gknd 4560 24 2,745 2,745 CD cord-010119-t1x9gknd 4560 25 ) ) -RRB- cord-010119-t1x9gknd 4560 26 versus versus IN cord-010119-t1x9gknd 4560 27 923 923 CD cord-010119-t1x9gknd 4560 28 U U NNP cord-010119-t1x9gknd 4560 29 / / SYM cord-010119-t1x9gknd 4560 30 L l NN cord-010119-t1x9gknd 4560 31 ( ( -LRB- cord-010119-t1x9gknd 4560 32 472 472 CD cord-010119-t1x9gknd 4560 33 - - SYM cord-010119-t1x9gknd 4560 34 1,796 1,796 CD cord-010119-t1x9gknd 4560 35 ) ) -RRB- cord-010119-t1x9gknd 4560 36 for for IN cord-010119-t1x9gknd 4560 37 CT CT NNP cord-010119-t1x9gknd 4560 38 group group NN cord-010119-t1x9gknd 4560 39 . . . cord-010119-t1x9gknd 4561 1 Results/ Results/ . cord-010119-t1x9gknd 4562 1 Finding find VBG cord-010119-t1x9gknd 4562 2 : : : cord-010119-t1x9gknd 4562 3 All all DT cord-010119-t1x9gknd 4562 4 pts pt NNS cord-010119-t1x9gknd 4562 5 were be VBD cord-010119-t1x9gknd 4562 6 treated treat VBN cord-010119-t1x9gknd 4562 7 with with IN cord-010119-t1x9gknd 4562 8 dietary dietary JJ cord-010119-t1x9gknd 4562 9 restriction restriction NN cord-010119-t1x9gknd 4562 10 ( ( -LRB- cord-010119-t1x9gknd 4562 11 lipid lipid NN cord-010119-t1x9gknd 4562 12 - - HYPH cord-010119-t1x9gknd 4562 13 free free JJ cord-010119-t1x9gknd 4562 14 diet diet NN cord-010119-t1x9gknd 4562 15 , , , cord-010119-t1x9gknd 4562 16 or or CC cord-010119-t1x9gknd 4562 17 nothing nothing NN cord-010119-t1x9gknd 4562 18 by by IN cord-010119-t1x9gknd 4562 19 mouth mouth NN cord-010119-t1x9gknd 4562 20 ) ) -RRB- cord-010119-t1x9gknd 4562 21 and and CC cord-010119-t1x9gknd 4562 22 aggressive aggressive JJ cord-010119-t1x9gknd 4562 23 lipid lipid NN cord-010119-t1x9gknd 4562 24 lowering lower VBG cord-010119-t1x9gknd 4562 25 protocols protocol NNS cord-010119-t1x9gknd 4562 26 involving involve VBG cord-010119-t1x9gknd 4562 27 2 2 CD cord-010119-t1x9gknd 4562 28 - - SYM cord-010119-t1x9gknd 4562 29 3 3 CD cord-010119-t1x9gknd 4562 30 medications medication NNS cord-010119-t1x9gknd 4562 31 . . . cord-010119-t1x9gknd 4563 1 24/27 24/27 CD cord-010119-t1x9gknd 4563 2 ( ( -LRB- cord-010119-t1x9gknd 4563 3 89 89 CD cord-010119-t1x9gknd 4563 4 % % NN cord-010119-t1x9gknd 4563 5 ) ) -RRB- cord-010119-t1x9gknd 4563 6 of of IN cord-010119-t1x9gknd 4563 7 PE PE NNP cord-010119-t1x9gknd 4563 8 group group NN cord-010119-t1x9gknd 4563 9 and and CC cord-010119-t1x9gknd 4563 10 11/14 11/14 CD cord-010119-t1x9gknd 4563 11 ( ( -LRB- cord-010119-t1x9gknd 4563 12 79 79 CD cord-010119-t1x9gknd 4563 13 % % NN cord-010119-t1x9gknd 4563 14 ) ) -RRB- cord-010119-t1x9gknd 4563 15 of of IN cord-010119-t1x9gknd 4563 16 CT CT NNP cord-010119-t1x9gknd 4563 17 group group NN cord-010119-t1x9gknd 4563 18 received receive VBD cord-010119-t1x9gknd 4563 19 insulin insulin NN cord-010119-t1x9gknd 4563 20 therapy therapy NN cord-010119-t1x9gknd 4563 21 to to TO cord-010119-t1x9gknd 4563 22 manage manage VB cord-010119-t1x9gknd 4563 23 symptoms symptom NNS cord-010119-t1x9gknd 4563 24 ( ( -LRB- cord-010119-t1x9gknd 4563 25 sxs sxs NNP cord-010119-t1x9gknd 4563 26 ) ) -RRB- cord-010119-t1x9gknd 4563 27 of of IN cord-010119-t1x9gknd 4563 28 hyperglycemia hyperglycemia NN cord-010119-t1x9gknd 4563 29 and/or and/or CC cord-010119-t1x9gknd 4563 30 diabetic diabetic JJ cord-010119-t1x9gknd 4563 31 ketoacidosis ketoacidosis NN cord-010119-t1x9gknd 4563 32 . . . cord-010119-t1x9gknd 4564 1 20/27 20/27 CD cord-010119-t1x9gknd 4564 2 ( ( -LRB- cord-010119-t1x9gknd 4564 3 75 75 CD cord-010119-t1x9gknd 4564 4 % % NN cord-010119-t1x9gknd 4564 5 ) ) -RRB- cord-010119-t1x9gknd 4564 6 of of IN cord-010119-t1x9gknd 4564 7 PE PE NNP cord-010119-t1x9gknd 4564 8 group group NN cord-010119-t1x9gknd 4564 9 and and CC cord-010119-t1x9gknd 4564 10 6/14 6/14 CD cord-010119-t1x9gknd 4564 11 ( ( -LRB- cord-010119-t1x9gknd 4564 12 43 43 CD cord-010119-t1x9gknd 4564 13 % % NN cord-010119-t1x9gknd 4564 14 ) ) -RRB- cord-010119-t1x9gknd 4564 15 of of IN cord-010119-t1x9gknd 4564 16 CT CT NNP cord-010119-t1x9gknd 4564 17 group group NN cord-010119-t1x9gknd 4564 18 received receive VBD cord-010119-t1x9gknd 4564 19 heparin heparin JJ cord-010119-t1x9gknd 4564 20 therapy therapy NN cord-010119-t1x9gknd 4564 21 to to TO cord-010119-t1x9gknd 4564 22 stimulate stimulate VB cord-010119-t1x9gknd 4564 23 lipoprotein lipoprotein NN cord-010119-t1x9gknd 4564 24 lipase lipase NN cord-010119-t1x9gknd 4564 25 release release NN cord-010119-t1x9gknd 4564 26 . . . cord-010119-t1x9gknd 4565 1 The the DT cord-010119-t1x9gknd 4565 2 PE PE NNP cord-010119-t1x9gknd 4565 3 group group NN cord-010119-t1x9gknd 4565 4 underwent undergo VBD cord-010119-t1x9gknd 4565 5 an an DT cord-010119-t1x9gknd 4565 6 average average NN cord-010119-t1x9gknd 4565 7 of of IN cord-010119-t1x9gknd 4565 8 2.85 2.85 CD cord-010119-t1x9gknd 4565 9 PE PE NNP cord-010119-t1x9gknd 4565 10 treatments treatment NNS cord-010119-t1x9gknd 4565 11 ( ( -LRB- cord-010119-t1x9gknd 4565 12 txs txs NNP cord-010119-t1x9gknd 4565 13 ) ) -RRB- cord-010119-t1x9gknd 4565 14 ( ( -LRB- cord-010119-t1x9gknd 4565 15 median median NN cord-010119-t1x9gknd 4565 16 of of IN cord-010119-t1x9gknd 4565 17 2 2 CD cord-010119-t1x9gknd 4565 18 , , , cord-010119-t1x9gknd 4565 19 range range VBP cord-010119-t1x9gknd 4565 20 1 1 CD cord-010119-t1x9gknd 4565 21 - - SYM cord-010119-t1x9gknd 4565 22 4 4 CD cord-010119-t1x9gknd 4565 23 daily daily JJ cord-010119-t1x9gknd 4565 24 txs txs NNP cord-010119-t1x9gknd 4565 25 ) ) -RRB- cord-010119-t1x9gknd 4565 26 using use VBG cord-010119-t1x9gknd 4565 27 5 5 CD cord-010119-t1x9gknd 4565 28 % % NN cord-010119-t1x9gknd 4565 29 albumin albumin NN cord-010119-t1x9gknd 4565 30 ; ; : cord-010119-t1x9gknd 4565 31 7/27 7/27 CD cord-010119-t1x9gknd 4565 32 ( ( -LRB- cord-010119-t1x9gknd 4565 33 26 26 CD cord-010119-t1x9gknd 4565 34 % % NN cord-010119-t1x9gknd 4565 35 ) ) -RRB- cord-010119-t1x9gknd 4565 36 required require VBD cord-010119-t1x9gknd 4565 37 FFP FFP NNP cord-010119-t1x9gknd 4565 38 to to TO cord-010119-t1x9gknd 4565 39 treat treat VB cord-010119-t1x9gknd 4565 40 dilutional dilutional JJ cord-010119-t1x9gknd 4565 41 coagulopathy coagulopathy NN cord-010119-t1x9gknd 4565 42 . . . cord-010119-t1x9gknd 4566 1 In in IN cord-010119-t1x9gknd 4566 2 most most JJS cord-010119-t1x9gknd 4566 3 cases case NNS cord-010119-t1x9gknd 4566 4 , , , cord-010119-t1x9gknd 4566 5 we -PRON- PRP cord-010119-t1x9gknd 4566 6 did do VBD cord-010119-t1x9gknd 4566 7 not not RB cord-010119-t1x9gknd 4566 8 perform perform VB cord-010119-t1x9gknd 4566 9 PE PE NNP cord-010119-t1x9gknd 4566 10 txs txs FW cord-010119-t1x9gknd 4566 11 when when WRB cord-010119-t1x9gknd 4566 12 baseline baseline JJ cord-010119-t1x9gknd 4566 13 triglyceride triglyceride NN cord-010119-t1x9gknd 4566 14 levels level NNS cord-010119-t1x9gknd 4566 15 were be VBD cord-010119-t1x9gknd 4566 16 < < XX cord-010119-t1x9gknd 4566 17 3000 3000 CD cord-010119-t1x9gknd 4566 18 - - SYM cord-010119-t1x9gknd 4566 19 4000 4000 CD cord-010119-t1x9gknd 4566 20 mg mg NNP cord-010119-t1x9gknd 4566 21 / / SYM cord-010119-t1x9gknd 4566 22 dl dl NN cord-010119-t1x9gknd 4566 23 and and CC cord-010119-t1x9gknd 4566 24 lipase lipase NNP cord-010119-t1x9gknd 4567 1 < < XX cord-010119-t1x9gknd 4567 2 950 950 CD cord-010119-t1x9gknd 4567 3 - - HYPH cord-010119-t1x9gknd 4567 4 1375 1375 CD cord-010119-t1x9gknd 4567 5 U U NNP cord-010119-t1x9gknd 4567 6 / / SYM cord-010119-t1x9gknd 4567 7 L L NNP cord-010119-t1x9gknd 4567 8 ( ( -LRB- cord-010119-t1x9gknd 4567 9 2.5 2.5 CD cord-010119-t1x9gknd 4567 10 - - SYM cord-010119-t1x9gknd 4567 11 3.5 3.5 CD cord-010119-t1x9gknd 4567 12 X x NN cord-010119-t1x9gknd 4567 13 upper upper JJ cord-010119-t1x9gknd 4567 14 limit limit NN cord-010119-t1x9gknd 4567 15 of of IN cord-010119-t1x9gknd 4567 16 normal normal JJ cord-010119-t1x9gknd 4567 17 ) ) -RRB- cord-010119-t1x9gknd 4567 18 . . . cord-010119-t1x9gknd 4568 1 Mean mean JJ cord-010119-t1x9gknd 4568 2 triglyceride triglyceride NN cord-010119-t1x9gknd 4568 3 levels level NNS cord-010119-t1x9gknd 4568 4 after after IN cord-010119-t1x9gknd 4568 5 2 2 CD cord-010119-t1x9gknd 4568 6 PE pe NN cord-010119-t1x9gknd 4568 7 txs tx NNS cord-010119-t1x9gknd 4568 8 were be VBD cord-010119-t1x9gknd 4568 9 1,976 1,976 CD cord-010119-t1x9gknd 4568 10 mg mg NNP cord-010119-t1x9gknd 4568 11 / / SYM cord-010119-t1x9gknd 4568 12 dl dl NNP cord-010119-t1x9gknd 4568 13 ( ( -LRB- cord-010119-t1x9gknd 4568 14 627 627 CD cord-010119-t1x9gknd 4568 15 - - SYM cord-010119-t1x9gknd 4568 16 3,968 3,968 CD cord-010119-t1x9gknd 4568 17 ) ) -RRB- cord-010119-t1x9gknd 4568 18 for for IN cord-010119-t1x9gknd 4568 19 PE PE NNP cord-010119-t1x9gknd 4568 20 group group NN cord-010119-t1x9gknd 4568 21 ( ( -LRB- cord-010119-t1x9gknd 4568 22 mean mean VB cord-010119-t1x9gknd 4568 23 decrease decrease NN cord-010119-t1x9gknd 4568 24 72 72 CD cord-010119-t1x9gknd 4568 25 % % NN cord-010119-t1x9gknd 4568 26 ) ) -RRB- cord-010119-t1x9gknd 4568 27 ; ; : cord-010119-t1x9gknd 4568 28 mean mean VB cord-010119-t1x9gknd 4568 29 triglyceride triglyceride NN cord-010119-t1x9gknd 4568 30 levels level NNS cord-010119-t1x9gknd 4568 31 after after IN cord-010119-t1x9gknd 4568 32 48 48 CD cord-010119-t1x9gknd 4568 33 additional additional JJ cord-010119-t1x9gknd 4568 34 hours hour NNS cord-010119-t1x9gknd 4568 35 of of IN cord-010119-t1x9gknd 4568 36 ongoing ongoing JJ cord-010119-t1x9gknd 4568 37 CT CT NNP cord-010119-t1x9gknd 4568 38 were be VBD cord-010119-t1x9gknd 4568 39 1,576 1,576 CD cord-010119-t1x9gknd 4568 40 mg mg NNP cord-010119-t1x9gknd 4568 41 / / SYM cord-010119-t1x9gknd 4568 42 dl dl NNP cord-010119-t1x9gknd 4568 43 ( ( -LRB- cord-010119-t1x9gknd 4568 44 487 487 CD cord-010119-t1x9gknd 4568 45 - - SYM cord-010119-t1x9gknd 4568 46 2,873 2,873 CD cord-010119-t1x9gknd 4568 47 ) ) -RRB- cord-010119-t1x9gknd 4568 48 for for IN cord-010119-t1x9gknd 4568 49 CT CT NNP cord-010119-t1x9gknd 4568 50 group group NN cord-010119-t1x9gknd 4568 51 ( ( -LRB- cord-010119-t1x9gknd 4569 1 mean mean VB cord-010119-t1x9gknd 4569 2 decrease decrease NN cord-010119-t1x9gknd 4569 3 50 50 CD cord-010119-t1x9gknd 4569 4 % % NN cord-010119-t1x9gknd 4569 5 ) ) -RRB- cord-010119-t1x9gknd 4569 6 . . . cord-010119-t1x9gknd 4570 1 While while IN cord-010119-t1x9gknd 4570 2 the the DT cord-010119-t1x9gknd 4570 3 PE PE NNP cord-010119-t1x9gknd 4570 4 group group NN cord-010119-t1x9gknd 4570 5 achieved achieve VBD cord-010119-t1x9gknd 4570 6 a a DT cord-010119-t1x9gknd 4570 7 greater great JJR cord-010119-t1x9gknd 4570 8 mean mean JJ cord-010119-t1x9gknd 4570 9 decrease decrease NN cord-010119-t1x9gknd 4570 10 in in IN cord-010119-t1x9gknd 4570 11 triglyceride triglyceride NN cord-010119-t1x9gknd 4570 12 levels level NNS cord-010119-t1x9gknd 4570 13 after after IN cord-010119-t1x9gknd 4570 14 2 2 CD cord-010119-t1x9gknd 4570 15 PE pe NN cord-010119-t1x9gknd 4570 16 txs txs NN cord-010119-t1x9gknd 4570 17 ( ( -LRB- cord-010119-t1x9gknd 4570 18 compared compare VBN cord-010119-t1x9gknd 4570 19 to to IN cord-010119-t1x9gknd 4570 20 the the DT cord-010119-t1x9gknd 4570 21 CT CT NNP cord-010119-t1x9gknd 4570 22 group group NN cord-010119-t1x9gknd 4570 23 after after IN cord-010119-t1x9gknd 4570 24 48 48 CD cord-010119-t1x9gknd 4570 25 hours hour NNS cord-010119-t1x9gknd 4570 26 of of IN cord-010119-t1x9gknd 4570 27 CT CT NNP cord-010119-t1x9gknd 4570 28 ) ) -RRB- cord-010119-t1x9gknd 4570 29 , , , cord-010119-t1x9gknd 4570 30 both both DT cord-010119-t1x9gknd 4570 31 groups group NNS cord-010119-t1x9gknd 4570 32 experienced experience VBD cord-010119-t1x9gknd 4570 33 marked mark VBN cord-010119-t1x9gknd 4570 34 improvement improvement NN cord-010119-t1x9gknd 4570 35 in in IN cord-010119-t1x9gknd 4570 36 clinical clinical JJ cord-010119-t1x9gknd 4570 37 sxs sxs NN cord-010119-t1x9gknd 4570 38 of of IN cord-010119-t1x9gknd 4570 39 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4570 40 and and CC cord-010119-t1x9gknd 4570 41 hyperglycemia hyperglycemia NN cord-010119-t1x9gknd 4570 42 ( ( -LRB- cord-010119-t1x9gknd 4570 43 p>0.05 p>0.05 NNP cord-010119-t1x9gknd 4570 44 ) ) -RRB- cord-010119-t1x9gknd 4570 45 . . . cord-010119-t1x9gknd 4571 1 Limitations limitation NNS cord-010119-t1x9gknd 4571 2 of of IN cord-010119-t1x9gknd 4571 3 the the DT cord-010119-t1x9gknd 4571 4 retrospective retrospective JJ cord-010119-t1x9gknd 4571 5 cohort cohort NN cord-010119-t1x9gknd 4571 6 study study NN cord-010119-t1x9gknd 4571 7 include include VBP cord-010119-t1x9gknd 4571 8 lack lack NN cord-010119-t1x9gknd 4571 9 of of IN cord-010119-t1x9gknd 4571 10 long long JJ cord-010119-t1x9gknd 4571 11 - - HYPH cord-010119-t1x9gknd 4571 12 term term NN cord-010119-t1x9gknd 4571 13 follow follow NN cord-010119-t1x9gknd 4571 14 - - HYPH cord-010119-t1x9gknd 4571 15 up up NN cord-010119-t1x9gknd 4571 16 . . . cord-010119-t1x9gknd 4572 1 Conclusion conclusion NN cord-010119-t1x9gknd 4572 2 : : : cord-010119-t1x9gknd 4573 1 This this DT cord-010119-t1x9gknd 4573 2 small small JJ cord-010119-t1x9gknd 4573 3 study study NN cord-010119-t1x9gknd 4573 4 adds add VBZ cord-010119-t1x9gknd 4573 5 to to IN cord-010119-t1x9gknd 4573 6 the the DT cord-010119-t1x9gknd 4573 7 literature literature NN cord-010119-t1x9gknd 4573 8 which which WDT cord-010119-t1x9gknd 4573 9 demonstrates demonstrate VBZ cord-010119-t1x9gknd 4573 10 that that IN cord-010119-t1x9gknd 4573 11 plasma plasma NN cord-010119-t1x9gknd 4573 12 exchange exchange NN cord-010119-t1x9gknd 4573 13 is be VBZ cord-010119-t1x9gknd 4573 14 very very RB cord-010119-t1x9gknd 4573 15 effective effective JJ cord-010119-t1x9gknd 4573 16 in in IN cord-010119-t1x9gknd 4573 17 rapidly rapidly RB cord-010119-t1x9gknd 4573 18 lowering lower VBG cord-010119-t1x9gknd 4573 19 triglyceride triglyceride NN cord-010119-t1x9gknd 4573 20 levels level NNS cord-010119-t1x9gknd 4573 21 in in IN cord-010119-t1x9gknd 4573 22 pts pts NN cord-010119-t1x9gknd 4573 23 with with IN cord-010119-t1x9gknd 4573 24 acute acute JJ cord-010119-t1x9gknd 4573 25 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4573 26 and and CC cord-010119-t1x9gknd 4573 27 hypertriglyceridemia hypertriglyceridemia NN cord-010119-t1x9gknd 4573 28 . . . cord-010119-t1x9gknd 4574 1 It -PRON- PRP cord-010119-t1x9gknd 4574 2 suggests suggest VBZ cord-010119-t1x9gknd 4574 3 that that IN cord-010119-t1x9gknd 4574 4 there there EX cord-010119-t1x9gknd 4574 5 may may MD cord-010119-t1x9gknd 4574 6 be be VB cord-010119-t1x9gknd 4574 7 a a DT cord-010119-t1x9gknd 4574 8 threshold threshold NN cord-010119-t1x9gknd 4574 9 ( ( -LRB- cord-010119-t1x9gknd 4574 10 or or CC cord-010119-t1x9gknd 4574 11 range range NN cord-010119-t1x9gknd 4574 12 ) ) -RRB- cord-010119-t1x9gknd 4574 13 of of IN cord-010119-t1x9gknd 4574 14 triglyceride triglyceride NN cord-010119-t1x9gknd 4574 15 and and CC cord-010119-t1x9gknd 4574 16 lipase lipase NN cord-010119-t1x9gknd 4574 17 levels level NNS cord-010119-t1x9gknd 4574 18 below below IN cord-010119-t1x9gknd 4574 19 which which WDT cord-010119-t1x9gknd 4574 20 conventional conventional JJ cord-010119-t1x9gknd 4574 21 therapy therapy NN cord-010119-t1x9gknd 4574 22 may may MD cord-010119-t1x9gknd 4574 23 be be VB cord-010119-t1x9gknd 4574 24 nearly nearly RB cord-010119-t1x9gknd 4574 25 as as RB cord-010119-t1x9gknd 4574 26 effective effective JJ cord-010119-t1x9gknd 4574 27 in in IN cord-010119-t1x9gknd 4574 28 achieving achieve VBG cord-010119-t1x9gknd 4574 29 clinical clinical JJ cord-010119-t1x9gknd 4574 30 resolution resolution NN cord-010119-t1x9gknd 4574 31 of of IN cord-010119-t1x9gknd 4574 32 symptoms symptom NNS cord-010119-t1x9gknd 4574 33 . . . cord-010119-t1x9gknd 4575 1 Randomized randomized JJ cord-010119-t1x9gknd 4575 2 controlled control VBN cord-010119-t1x9gknd 4575 3 trials trial NNS cord-010119-t1x9gknd 4575 4 would would MD cord-010119-t1x9gknd 4575 5 further further RB cord-010119-t1x9gknd 4575 6 elucidate elucidate VB cord-010119-t1x9gknd 4575 7 the the DT cord-010119-t1x9gknd 4575 8 appropriate appropriate JJ cord-010119-t1x9gknd 4575 9 use use NN cord-010119-t1x9gknd 4575 10 of of IN cord-010119-t1x9gknd 4575 11 adjunctive adjunctive JJ cord-010119-t1x9gknd 4575 12 plasma plasma NN cord-010119-t1x9gknd 4575 13 exchange exchange NN cord-010119-t1x9gknd 4575 14 in in IN cord-010119-t1x9gknd 4575 15 the the DT cord-010119-t1x9gknd 4575 16 setting setting NN cord-010119-t1x9gknd 4575 17 of of IN cord-010119-t1x9gknd 4575 18 hypertriglyceridemic hypertriglyceridemic JJ cord-010119-t1x9gknd 4575 19 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4575 20 . . . cord-010119-t1x9gknd 4576 1 Role role NN cord-010119-t1x9gknd 4576 2 of of IN cord-010119-t1x9gknd 4576 3 Plasma Plasma NNP cord-010119-t1x9gknd 4576 4 Replacement Replacement NNP cord-010119-t1x9gknd 4576 5 in in IN cord-010119-t1x9gknd 4576 6 Therapeutic Therapeutic NNP cord-010119-t1x9gknd 4576 7 Plasma Plasma NNP cord-010119-t1x9gknd 4576 8 Exchange Exchange NNP cord-010119-t1x9gknd 4576 9 for for IN cord-010119-t1x9gknd 4576 10 Hypertriglyceridemia Hypertriglyceridemia NNP cord-010119-t1x9gknd 4576 11 : : : cord-010119-t1x9gknd 4577 1 A a DT cord-010119-t1x9gknd 4577 2 Single Single NNP cord-010119-t1x9gknd 4577 3 Patient Patient NNP cord-010119-t1x9gknd 4577 4 Study Study NNP cord-010119-t1x9gknd 4577 5 Geoffrey Geoffrey NNP cord-010119-t1x9gknd 4577 6 Wool Wool NNP cord-010119-t1x9gknd 4577 7 * * NFP cord-010119-t1x9gknd 4577 8 and and CC cord-010119-t1x9gknd 4577 9 Angela Angela NNP cord-010119-t1x9gknd 4577 10 Treml Treml NNP cord-010119-t1x9gknd 4577 11 . . . cord-010119-t1x9gknd 4578 1 University University NNP cord-010119-t1x9gknd 4578 2 of of IN cord-010119-t1x9gknd 4578 3 Chicago Chicago NNP cord-010119-t1x9gknd 4578 4 Background Background NNP cord-010119-t1x9gknd 4578 5 / / SYM cord-010119-t1x9gknd 4578 6 Case Case NNP cord-010119-t1x9gknd 4578 7 Studies Studies NNPS cord-010119-t1x9gknd 4578 8 : : : cord-010119-t1x9gknd 4578 9 Our -PRON- PRP$ cord-010119-t1x9gknd 4578 10 apheresis apheresis NN cord-010119-t1x9gknd 4578 11 service service NN cord-010119-t1x9gknd 4578 12 performs perform VBZ cord-010119-t1x9gknd 4578 13 chronic chronic JJ cord-010119-t1x9gknd 4578 14 therapeutic therapeutic JJ cord-010119-t1x9gknd 4578 15 plasma plasma NN cord-010119-t1x9gknd 4578 16 exchanges exchange NNS cord-010119-t1x9gknd 4578 17 ( ( -LRB- cord-010119-t1x9gknd 4578 18 TPE TPE NNP cord-010119-t1x9gknd 4578 19 ) ) -RRB- cord-010119-t1x9gknd 4578 20 for for IN cord-010119-t1x9gknd 4578 21 a a DT cord-010119-t1x9gknd 4578 22 47-year 47-year JJ cord-010119-t1x9gknd 4578 23 - - HYPH cord-010119-t1x9gknd 4578 24 old old JJ cord-010119-t1x9gknd 4578 25 man man NN cord-010119-t1x9gknd 4578 26 with with IN cord-010119-t1x9gknd 4578 27 a a DT cord-010119-t1x9gknd 4578 28 chronic chronic JJ cord-010119-t1x9gknd 4578 29 history history NN cord-010119-t1x9gknd 4578 30 of of IN cord-010119-t1x9gknd 4578 31 hypertriglyceridemia hypertriglyceridemia NN cord-010119-t1x9gknd 4578 32 > > XX cord-010119-t1x9gknd 4579 1 1000 1000 CD cord-010119-t1x9gknd 4579 2 mg mg NNP cord-010119-t1x9gknd 4579 3 / / SYM cord-010119-t1x9gknd 4579 4 dL dL NNP cord-010119-t1x9gknd 4579 5 , , , cord-010119-t1x9gknd 4579 6 diabetes diabete VBZ cord-010119-t1x9gknd 4579 7 mellitus mellitus NN cord-010119-t1x9gknd 4579 8 type type NN cord-010119-t1x9gknd 4579 9 II II NNP cord-010119-t1x9gknd 4579 10 , , , cord-010119-t1x9gknd 4579 11 and and CC cord-010119-t1x9gknd 4579 12 chronic chronic JJ cord-010119-t1x9gknd 4579 13 abdominal abdominal JJ cord-010119-t1x9gknd 4579 14 pain pain NN cord-010119-t1x9gknd 4579 15 . . . cord-010119-t1x9gknd 4580 1 His -PRON- PRP$ cord-010119-t1x9gknd 4580 2 abdominal abdominal JJ cord-010119-t1x9gknd 4580 3 pain pain NN cord-010119-t1x9gknd 4580 4 is be VBZ cord-010119-t1x9gknd 4580 5 severe severe JJ cord-010119-t1x9gknd 4580 6 and and CC cord-010119-t1x9gknd 4580 7 persistent persistent JJ cord-010119-t1x9gknd 4580 8 , , , cord-010119-t1x9gknd 4580 9 but but CC cord-010119-t1x9gknd 4580 10 there there EX cord-010119-t1x9gknd 4580 11 is be VBZ cord-010119-t1x9gknd 4580 12 not not RB cord-010119-t1x9gknd 4580 13 overt overt JJ cord-010119-t1x9gknd 4580 14 evidence evidence NN cord-010119-t1x9gknd 4580 15 of of IN cord-010119-t1x9gknd 4580 16 chronic chronic JJ cord-010119-t1x9gknd 4580 17 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4580 18 on on IN cord-010119-t1x9gknd 4580 19 imaging image VBG cord-010119-t1x9gknd 4580 20 or or CC cord-010119-t1x9gknd 4580 21 fecal fecal JJ cord-010119-t1x9gknd 4580 22 elastase elastase NN cord-010119-t1x9gknd 4580 23 testing testing NN cord-010119-t1x9gknd 4580 24 . . . cord-010119-t1x9gknd 4581 1 Targeted target VBN cord-010119-t1x9gknd 4581 2 sequencing sequencing NN cord-010119-t1x9gknd 4581 3 has have VBZ cord-010119-t1x9gknd 4581 4 not not RB cord-010119-t1x9gknd 4581 5 revealed reveal VBN cord-010119-t1x9gknd 4581 6 a a DT cord-010119-t1x9gknd 4581 7 pathogenic pathogenic JJ cord-010119-t1x9gknd 4581 8 mutation mutation NN cord-010119-t1x9gknd 4581 9 to to TO cord-010119-t1x9gknd 4581 10 explain explain VB cord-010119-t1x9gknd 4581 11 the the DT cord-010119-t1x9gknd 4581 12 patient patient NN cord-010119-t1x9gknd 4581 13 's 's POS cord-010119-t1x9gknd 4581 14 hypertriglyceridemia hypertriglyceridemia NN cord-010119-t1x9gknd 4581 15 . . . cord-010119-t1x9gknd 4582 1 Hypertriglyceridemic Hypertriglyceridemic NNP cord-010119-t1x9gknd 4582 2 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4582 3 is be VBZ cord-010119-t1x9gknd 4582 4 a a DT cord-010119-t1x9gknd 4582 5 category category NN cord-010119-t1x9gknd 4582 6 III iii CD cord-010119-t1x9gknd 4582 7 indication indication NN cord-010119-t1x9gknd 4582 8 for for IN cord-010119-t1x9gknd 4582 9 TPE TPE NNP cord-010119-t1x9gknd 4582 10 by by IN cord-010119-t1x9gknd 4582 11 ASFA ASFA NNP cord-010119-t1x9gknd 4582 12 2016 2016 CD cord-010119-t1x9gknd 4582 13 guidelines guideline NNS cord-010119-t1x9gknd 4582 14 , , , cord-010119-t1x9gknd 4582 15 in in IN cord-010119-t1x9gknd 4582 16 a a DT cord-010119-t1x9gknd 4582 17 patient patient NN cord-010119-t1x9gknd 4582 18 unresponsive unresponsive JJ cord-010119-t1x9gknd 4582 19 to to TO cord-010119-t1x9gknd 4582 20 optimal optimal JJ cord-010119-t1x9gknd 4582 21 medical medical JJ cord-010119-t1x9gknd 4582 22 management management NN cord-010119-t1x9gknd 4582 23 . . . cord-010119-t1x9gknd 4583 1 ASFA ASFA NNP cord-010119-t1x9gknd 4583 2 2016 2016 CD cord-010119-t1x9gknd 4583 3 guidelines guideline NNS cord-010119-t1x9gknd 4583 4 for for IN cord-010119-t1x9gknd 4583 5 this this DT cord-010119-t1x9gknd 4583 6 disorder disorder NN cord-010119-t1x9gknd 4583 7 state state NN cord-010119-t1x9gknd 4583 8 that that IN cord-010119-t1x9gknd 4583 9 " " `` cord-010119-t1x9gknd 4583 10 Some some DT cord-010119-t1x9gknd 4583 11 have have VBP cord-010119-t1x9gknd 4583 12 used use VBN cord-010119-t1x9gknd 4583 13 plasma plasma NN cord-010119-t1x9gknd 4583 14 as as IN cord-010119-t1x9gknd 4583 15 it -PRON- PRP cord-010119-t1x9gknd 4583 16 contains contain VBZ cord-010119-t1x9gknd 4583 17 lipoprotein lipoprotein NN cord-010119-t1x9gknd 4583 18 lipase lipase NN cord-010119-t1x9gknd 4583 19 and and CC cord-010119-t1x9gknd 4583 20 could could MD cord-010119-t1x9gknd 4583 21 enhance enhance VB cord-010119-t1x9gknd 4583 22 triglyceride triglyceride NN cord-010119-t1x9gknd 4583 23 ( ( -LRB- cord-010119-t1x9gknd 4583 24 TG TG NNP cord-010119-t1x9gknd 4583 25 ) ) -RRB- cord-010119-t1x9gknd 4583 26 removal removal NN cord-010119-t1x9gknd 4583 27 . . . cord-010119-t1x9gknd 4584 1 No no DT cord-010119-t1x9gknd 4584 2 direct direct JJ cord-010119-t1x9gknd 4584 3 comparisons comparison NNS cord-010119-t1x9gknd 4584 4 of of IN cord-010119-t1x9gknd 4584 5 replacement replacement NN cord-010119-t1x9gknd 4584 6 fluids fluid NNS cord-010119-t1x9gknd 4584 7 have have VBP cord-010119-t1x9gknd 4584 8 been be VBN cord-010119-t1x9gknd 4584 9 reported report VBN cord-010119-t1x9gknd 4584 10 " " '' cord-010119-t1x9gknd 4584 11 . . . cord-010119-t1x9gknd 4584 12 _SP cord-010119-t1x9gknd 4585 1 There there EX cord-010119-t1x9gknd 4585 2 are be VBP cord-010119-t1x9gknd 4585 3 three three CD cord-010119-t1x9gknd 4585 4 apheresis apheresis NN cord-010119-t1x9gknd 4585 5 physicians physician NNS cord-010119-t1x9gknd 4585 6 on on IN cord-010119-t1x9gknd 4585 7 our -PRON- PRP$ cord-010119-t1x9gknd 4585 8 service service NN cord-010119-t1x9gknd 4585 9 and and CC cord-010119-t1x9gknd 4585 10 use use NN cord-010119-t1x9gknd 4585 11 of of IN cord-010119-t1x9gknd 4585 12 partial partial JJ cord-010119-t1x9gknd 4585 13 plasma plasma NN cord-010119-t1x9gknd 4585 14 replacement replacement NN cord-010119-t1x9gknd 4585 15 has have VBZ cord-010119-t1x9gknd 4585 16 been be VBN cord-010119-t1x9gknd 4585 17 variable variable JJ cord-010119-t1x9gknd 4585 18 . . . cord-010119-t1x9gknd 4586 1 We -PRON- PRP cord-010119-t1x9gknd 4586 2 undertook undertake VBD cord-010119-t1x9gknd 4586 3 a a DT cord-010119-t1x9gknd 4586 4 retrospective retrospective JJ cord-010119-t1x9gknd 4586 5 study study NN cord-010119-t1x9gknd 4586 6 of of IN cord-010119-t1x9gknd 4586 7 the the DT cord-010119-t1x9gknd 4586 8 efficacy efficacy NN cord-010119-t1x9gknd 4586 9 of of IN cord-010119-t1x9gknd 4586 10 partial partial JJ cord-010119-t1x9gknd 4586 11 plasma plasma NN cord-010119-t1x9gknd 4586 12 replacement replacement NN cord-010119-t1x9gknd 4586 13 in in IN cord-010119-t1x9gknd 4586 14 this this DT cord-010119-t1x9gknd 4586 15 patient patient NN cord-010119-t1x9gknd 4586 16 . . . cord-010119-t1x9gknd 4587 1 Study Study NNP cord-010119-t1x9gknd 4587 2 Design Design NNP cord-010119-t1x9gknd 4587 3 / / SYM cord-010119-t1x9gknd 4587 4 Method method NN cord-010119-t1x9gknd 4587 5 : : : cord-010119-t1x9gknd 4587 6 We -PRON- PRP cord-010119-t1x9gknd 4587 7 have have VBP cord-010119-t1x9gknd 4587 8 performed perform VBN cord-010119-t1x9gknd 4587 9 39 39 CD cord-010119-t1x9gknd 4587 10 TPE tpe NN cord-010119-t1x9gknd 4587 11 on on IN cord-010119-t1x9gknd 4587 12 this this DT cord-010119-t1x9gknd 4587 13 patient patient NN cord-010119-t1x9gknd 4587 14 . . . cord-010119-t1x9gknd 4588 1 We -PRON- PRP cord-010119-t1x9gknd 4588 2 performed perform VBD cord-010119-t1x9gknd 4588 3 a a DT cord-010119-t1x9gknd 4588 4 chart chart NN cord-010119-t1x9gknd 4588 5 review review NN cord-010119-t1x9gknd 4588 6 to to TO cord-010119-t1x9gknd 4588 7 capture capture VB cord-010119-t1x9gknd 4588 8 replacement replacement NN cord-010119-t1x9gknd 4588 9 fluid fluid NN cord-010119-t1x9gknd 4588 10 use use NN cord-010119-t1x9gknd 4588 11 and and CC cord-010119-t1x9gknd 4588 12 pre pre JJ cord-010119-t1x9gknd 4588 13 - - JJ cord-010119-t1x9gknd 4588 14 and and CC cord-010119-t1x9gknd 4588 15 post post JJ cord-010119-t1x9gknd 4588 16 - - JJ cord-010119-t1x9gknd 4588 17 TG tg JJ cord-010119-t1x9gknd 4588 18 levels level NNS cord-010119-t1x9gknd 4588 19 , , , cord-010119-t1x9gknd 4588 20 if if IN cord-010119-t1x9gknd 4588 21 drawn draw VBN cord-010119-t1x9gknd 4588 22 . . . cord-010119-t1x9gknd 4589 1 TPE TPE NNP cord-010119-t1x9gknd 4589 2 was be VBD cord-010119-t1x9gknd 4589 3 performed perform VBN cord-010119-t1x9gknd 4589 4 using use VBG cord-010119-t1x9gknd 4589 5 Spectra Spectra NNP cord-010119-t1x9gknd 4589 6 Optia Optia NNP cord-010119-t1x9gknd 4589 7 ( ( -LRB- cord-010119-t1x9gknd 4589 8 Terumo Terumo NNP cord-010119-t1x9gknd 4589 9 , , , cord-010119-t1x9gknd 4589 10 Lakewood Lakewood NNP cord-010119-t1x9gknd 4589 11 , , , cord-010119-t1x9gknd 4589 12 CO CO NNP cord-010119-t1x9gknd 4589 13 ) ) -RRB- cord-010119-t1x9gknd 4589 14 exchanging exchange VBG cord-010119-t1x9gknd 4589 15 approximately approximately RB cord-010119-t1x9gknd 4589 16 one one CD cord-010119-t1x9gknd 4589 17 plasma plasma NN cord-010119-t1x9gknd 4589 18 volume volume NN cord-010119-t1x9gknd 4589 19 , , , cord-010119-t1x9gknd 4589 20 using use VBG cord-010119-t1x9gknd 4589 21 entirely entirely RB cord-010119-t1x9gknd 4589 22 5 5 CD cord-010119-t1x9gknd 4589 23 % % NN cord-010119-t1x9gknd 4589 24 albumin albumin NN cord-010119-t1x9gknd 4589 25 for for IN cord-010119-t1x9gknd 4589 26 exchange exchange NN cord-010119-t1x9gknd 4589 27 fluid fluid NN cord-010119-t1x9gknd 4589 28 ( ( -LRB- cord-010119-t1x9gknd 4589 29 100 100 CD cord-010119-t1x9gknd 4589 30 % % NN cord-010119-t1x9gknd 4589 31 albumin albumin NN cord-010119-t1x9gknd 4589 32 procedures procedure NNS cord-010119-t1x9gknd 4589 33 ) ) -RRB- cord-010119-t1x9gknd 4589 34 or or CC cord-010119-t1x9gknd 4589 35 partial partial JJ cord-010119-t1x9gknd 4589 36 plasma plasma NN cord-010119-t1x9gknd 4589 37 replacement replacement NN cord-010119-t1x9gknd 4589 38 ( ( -LRB- cord-010119-t1x9gknd 4589 39 2 2 CD cord-010119-t1x9gknd 4589 40 - - SYM cord-010119-t1x9gknd 4589 41 3 3 CD cord-010119-t1x9gknd 4589 42 units unit NNS cord-010119-t1x9gknd 4589 43 of of IN cord-010119-t1x9gknd 4589 44 thawed thawed JJ cord-010119-t1x9gknd 4589 45 plasma plasma NN cord-010119-t1x9gknd 4589 46 ) ) -RRB- cord-010119-t1x9gknd 4589 47 . . . cord-010119-t1x9gknd 4590 1 Twenty twenty CD cord-010119-t1x9gknd 4590 2 - - HYPH cord-010119-t1x9gknd 4590 3 six six CD cord-010119-t1x9gknd 4590 4 TPE tpe NN cord-010119-t1x9gknd 4590 5 had have VBD cord-010119-t1x9gknd 4590 6 pre pre VBN cord-010119-t1x9gknd 4590 7 - - JJ cord-010119-t1x9gknd 4590 8 and and CC cord-010119-t1x9gknd 4590 9 post post JJ cord-010119-t1x9gknd 4590 10 - - JJ cord-010119-t1x9gknd 4590 11 procedure procedure JJ cord-010119-t1x9gknd 4590 12 TG TG NNP cord-010119-t1x9gknd 4590 13 values value NNS cord-010119-t1x9gknd 4590 14 available available JJ cord-010119-t1x9gknd 4590 15 . . . cord-010119-t1x9gknd 4591 1 We -PRON- PRP cord-010119-t1x9gknd 4591 2 determined determine VBD cord-010119-t1x9gknd 4591 3 the the DT cord-010119-t1x9gknd 4591 4 percent percent NN cord-010119-t1x9gknd 4591 5 TG TG NNP cord-010119-t1x9gknd 4591 6 reduction reduction NN cord-010119-t1x9gknd 4591 7 achieved achieve VBN cord-010119-t1x9gknd 4591 8 by by IN cord-010119-t1x9gknd 4591 9 the the DT cord-010119-t1x9gknd 4591 10 TPE TPE NNP cord-010119-t1x9gknd 4591 11 . . . cord-010119-t1x9gknd 4592 1 We -PRON- PRP cord-010119-t1x9gknd 4592 2 also also RB cord-010119-t1x9gknd 4592 3 determined determine VBD cord-010119-t1x9gknd 4592 4 the the DT cord-010119-t1x9gknd 4592 5 daily daily JJ cord-010119-t1x9gknd 4592 6 rate rate NN cord-010119-t1x9gknd 4592 7 of of IN cord-010119-t1x9gknd 4592 8 TG TG NNP cord-010119-t1x9gknd 4592 9 increase increase NN cord-010119-t1x9gknd 4592 10 until until IN cord-010119-t1x9gknd 4592 11 the the DT cord-010119-t1x9gknd 4592 12 next next JJ cord-010119-t1x9gknd 4592 13 TPE TPE NNP cord-010119-t1x9gknd 4592 14 appointment appointment NN cord-010119-t1x9gknd 4592 15 ( ( -LRB- cord-010119-t1x9gknd 4592 16 to to TO cord-010119-t1x9gknd 4592 17 assess assess VB cord-010119-t1x9gknd 4592 18 any any DT cord-010119-t1x9gknd 4592 19 long long JJ cord-010119-t1x9gknd 4592 20 - - HYPH cord-010119-t1x9gknd 4592 21 term term NN cord-010119-t1x9gknd 4592 22 effects effect NNS cord-010119-t1x9gknd 4592 23 of of IN cord-010119-t1x9gknd 4592 24 plasma plasma NN cord-010119-t1x9gknd 4592 25 preventing prevent VBG cord-010119-t1x9gknd 4592 26 TG TG NNP cord-010119-t1x9gknd 4592 27 rebound rebound NN cord-010119-t1x9gknd 4592 28 ) ) -RRB- cord-010119-t1x9gknd 4592 29 . . . cord-010119-t1x9gknd 4593 1 Significance significance NN cord-010119-t1x9gknd 4593 2 was be VBD cord-010119-t1x9gknd 4593 3 assessed assess VBN cord-010119-t1x9gknd 4593 4 by by IN cord-010119-t1x9gknd 4593 5 Student Student NNP cord-010119-t1x9gknd 4593 6 's 's POS cord-010119-t1x9gknd 4593 7 t t NN cord-010119-t1x9gknd 4593 8 - - HYPH cord-010119-t1x9gknd 4593 9 test test NN cord-010119-t1x9gknd 4593 10 ( ( -LRB- cord-010119-t1x9gknd 4593 11 one one CD cord-010119-t1x9gknd 4593 12 - - HYPH cord-010119-t1x9gknd 4593 13 tailed tailed JJ cord-010119-t1x9gknd 4593 14 , , , cord-010119-t1x9gknd 4593 15 heteroscedastic heteroscedastic JJ cord-010119-t1x9gknd 4593 16 ) ) -RRB- cord-010119-t1x9gknd 4593 17 . . . cord-010119-t1x9gknd 4594 1 Results/ Results/ . cord-010119-t1x9gknd 4595 1 Finding finding NN cord-010119-t1x9gknd 4595 2 : : : cord-010119-t1x9gknd 4596 1 Twelve twelve CD cord-010119-t1x9gknd 4596 2 TPE TPE NNP cord-010119-t1x9gknd 4596 3 were be VBD cord-010119-t1x9gknd 4596 4 performed perform VBN cord-010119-t1x9gknd 4596 5 with with IN cord-010119-t1x9gknd 4596 6 partial partial JJ cord-010119-t1x9gknd 4596 7 plasma plasma NN cord-010119-t1x9gknd 4596 8 replacement replacement NN cord-010119-t1x9gknd 4596 9 , , , cord-010119-t1x9gknd 4596 10 while while IN cord-010119-t1x9gknd 4596 11 27 27 CD cord-010119-t1x9gknd 4596 12 were be VBD cord-010119-t1x9gknd 4596 13 performed perform VBN cord-010119-t1x9gknd 4596 14 with with IN cord-010119-t1x9gknd 4596 15 100 100 CD cord-010119-t1x9gknd 4596 16 % % NN cord-010119-t1x9gknd 4596 17 albumin albumin NN cord-010119-t1x9gknd 4596 18 replacement replacement NN cord-010119-t1x9gknd 4596 19 . . . cord-010119-t1x9gknd 4597 1 Table table NN cord-010119-t1x9gknd 4597 2 shows show VBZ cord-010119-t1x9gknd 4597 3 that that IN cord-010119-t1x9gknd 4597 4 partial partial JJ cord-010119-t1x9gknd 4597 5 plasma plasma NN cord-010119-t1x9gknd 4597 6 replacement replacement NN cord-010119-t1x9gknd 4597 7 was be VBD cord-010119-t1x9gknd 4597 8 associated associate VBN cord-010119-t1x9gknd 4597 9 with with IN cord-010119-t1x9gknd 4597 10 significantly significantly RB cord-010119-t1x9gknd 4597 11 greater great JJR cord-010119-t1x9gknd 4597 12 % % NN cord-010119-t1x9gknd 4597 13 TG TG NNP cord-010119-t1x9gknd 4597 14 reduction reduction NN cord-010119-t1x9gknd 4597 15 . . . cord-010119-t1x9gknd 4598 1 The the DT cord-010119-t1x9gknd 4598 2 rate rate NN cord-010119-t1x9gknd 4598 3 of of IN cord-010119-t1x9gknd 4598 4 subsequent subsequent JJ cord-010119-t1x9gknd 4598 5 daily daily JJ cord-010119-t1x9gknd 4598 6 TG TG NNP cord-010119-t1x9gknd 4598 7 increase increase NN cord-010119-t1x9gknd 4598 8 was be VBD cord-010119-t1x9gknd 4598 9 also also RB cord-010119-t1x9gknd 4598 10 lower low JJR cord-010119-t1x9gknd 4598 11 with with IN cord-010119-t1x9gknd 4598 12 partial partial JJ cord-010119-t1x9gknd 4598 13 plasma plasma NN cord-010119-t1x9gknd 4598 14 replacement replacement NN cord-010119-t1x9gknd 4598 15 , , , cord-010119-t1x9gknd 4598 16 but but CC cord-010119-t1x9gknd 4598 17 this this DT cord-010119-t1x9gknd 4598 18 did do VBD cord-010119-t1x9gknd 4598 19 not not RB cord-010119-t1x9gknd 4598 20 meet meet VB cord-010119-t1x9gknd 4598 21 significance significance NN cord-010119-t1x9gknd 4598 22 . . . cord-010119-t1x9gknd 4599 1 One one CD cord-010119-t1x9gknd 4599 2 mild mild JJ cord-010119-t1x9gknd 4599 3 allergic allergic JJ cord-010119-t1x9gknd 4599 4 reaction reaction NN cord-010119-t1x9gknd 4599 5 has have VBZ cord-010119-t1x9gknd 4599 6 occurred occur VBN cord-010119-t1x9gknd 4599 7 during during IN cord-010119-t1x9gknd 4599 8 partial partial JJ cord-010119-t1x9gknd 4599 9 plasma plasma NN cord-010119-t1x9gknd 4599 10 replacement replacement NN cord-010119-t1x9gknd 4599 11 which which WDT cord-010119-t1x9gknd 4599 12 responded respond VBD cord-010119-t1x9gknd 4599 13 quickly quickly RB cord-010119-t1x9gknd 4599 14 to to IN cord-010119-t1x9gknd 4599 15 additional additional JJ cord-010119-t1x9gknd 4599 16 IV IV NNP cord-010119-t1x9gknd 4599 17 diphenhydramine diphenhydramine NN cord-010119-t1x9gknd 4599 18 . . . cord-010119-t1x9gknd 4600 1 Conclusion conclusion NN cord-010119-t1x9gknd 4600 2 : : : cord-010119-t1x9gknd 4600 3 We -PRON- PRP cord-010119-t1x9gknd 4600 4 have have VBP cord-010119-t1x9gknd 4600 5 performed perform VBN cord-010119-t1x9gknd 4600 6 an an DT cord-010119-t1x9gknd 4600 7 ad ad FW cord-010119-t1x9gknd 4600 8 hoc hoc FW cord-010119-t1x9gknd 4600 9 cross cross NN cord-010119-t1x9gknd 4600 10 - - HYPH cord-010119-t1x9gknd 4600 11 over over RP cord-010119-t1x9gknd 4600 12 study study NN cord-010119-t1x9gknd 4600 13 on on IN cord-010119-t1x9gknd 4600 14 the the DT cord-010119-t1x9gknd 4600 15 efficacy efficacy NN cord-010119-t1x9gknd 4600 16 of of IN cord-010119-t1x9gknd 4600 17 partial partial JJ cord-010119-t1x9gknd 4600 18 plasma plasma NN cord-010119-t1x9gknd 4600 19 replacement replacement NN cord-010119-t1x9gknd 4600 20 in in IN cord-010119-t1x9gknd 4600 21 TPE TPE NNP cord-010119-t1x9gknd 4600 22 for for IN cord-010119-t1x9gknd 4600 23 hypertriglyceridemia hypertriglyceridemia NN cord-010119-t1x9gknd 4600 24 . . . cord-010119-t1x9gknd 4601 1 In in IN cord-010119-t1x9gknd 4601 2 this this DT cord-010119-t1x9gknd 4601 3 patient patient NN cord-010119-t1x9gknd 4601 4 without without IN cord-010119-t1x9gknd 4601 5 lipoprotein lipoprotein NN cord-010119-t1x9gknd 4601 6 lipase lipase NN cord-010119-t1x9gknd 4601 7 mutations mutation NNS cord-010119-t1x9gknd 4601 8 , , , cord-010119-t1x9gknd 4601 9 plasma plasma NN cord-010119-t1x9gknd 4601 10 was be VBD cord-010119-t1x9gknd 4601 11 significantly significantly RB cord-010119-t1x9gknd 4601 12 associated associate VBN cord-010119-t1x9gknd 4601 13 with with IN cord-010119-t1x9gknd 4601 14 improved improved JJ cord-010119-t1x9gknd 4601 15 % % NN cord-010119-t1x9gknd 4601 16 TG TG NNP cord-010119-t1x9gknd 4601 17 reduction reduction NN cord-010119-t1x9gknd 4601 18 , , , cord-010119-t1x9gknd 4601 19 but but CC cord-010119-t1x9gknd 4601 20 not not RB cord-010119-t1x9gknd 4601 21 with with IN cord-010119-t1x9gknd 4601 22 prevention prevention NN cord-010119-t1x9gknd 4601 23 of of IN cord-010119-t1x9gknd 4601 24 post post JJ cord-010119-t1x9gknd 4601 25 - - JJ cord-010119-t1x9gknd 4601 26 TPE TPE NNP cord-010119-t1x9gknd 4601 27 TG TG NNP cord-010119-t1x9gknd 4601 28 rebound rebound NN cord-010119-t1x9gknd 4601 29 . . . cord-010119-t1x9gknd 4602 1 Safety safety NN cord-010119-t1x9gknd 4602 2 and and CC cord-010119-t1x9gknd 4602 3 Efficacy Efficacy NNP cord-010119-t1x9gknd 4602 4 of of IN cord-010119-t1x9gknd 4602 5 Local Local NNP cord-010119-t1x9gknd 4602 6 Albumin Albumin NNP cord-010119-t1x9gknd 4602 7 Replacement Replacement NNP cord-010119-t1x9gknd 4602 8 for for IN cord-010119-t1x9gknd 4602 9 Therapeutic Therapeutic NNP cord-010119-t1x9gknd 4602 10 Plasma Plasma NNP cord-010119-t1x9gknd 4602 11 Exchange Exchange NNP cord-010119-t1x9gknd 4603 1 Phandee Phandee NNP cord-010119-t1x9gknd 4603 2 Watanaboonyongcharoen Watanaboonyongcharoen NNP cord-010119-t1x9gknd 4603 3 * * NFP cord-010119-t1x9gknd 4603 4 1,2 1,2 CD cord-010119-t1x9gknd 4603 5 , , , cord-010119-t1x9gknd 4603 6 Metha Metha NNP cord-010119-t1x9gknd 4603 7 Apiwattanakul Apiwattanakul NNP cord-010119-t1x9gknd 4603 8 3 3 CD cord-010119-t1x9gknd 4603 9 , , , cord-010119-t1x9gknd 4603 10 Sompis Sompis NNP cord-010119-t1x9gknd 4603 11 Santipong Santipong NNP cord-010119-t1x9gknd 4603 12 2 2 CD cord-010119-t1x9gknd 4603 13 , , , cord-010119-t1x9gknd 4603 14 Jutaluk Jutaluk NNP cord-010119-t1x9gknd 4603 15 Jaipian Jaipian NNP cord-010119-t1x9gknd 4603 16 2 2 CD cord-010119-t1x9gknd 4603 17 , , , cord-010119-t1x9gknd 4603 18 Jettawan Jettawan NNP cord-010119-t1x9gknd 4603 19 Siriaksorn Siriaksorn NNP cord-010119-t1x9gknd 4603 20 2 2 CD cord-010119-t1x9gknd 4603 21 and and CC cord-010119-t1x9gknd 4603 22 Ponlapat Ponlapat NNP cord-010119-t1x9gknd 4603 23 Rojnuckarin Rojnuckarin NNP cord-010119-t1x9gknd 4603 24 1 1 CD cord-010119-t1x9gknd 4603 25 . . . cord-010119-t1x9gknd 4603 26 1 1 CD cord-010119-t1x9gknd 4603 27 Chulalongkorn Chulalongkorn NNP cord-010119-t1x9gknd 4603 28 University University NNP cord-010119-t1x9gknd 4603 29 , , , cord-010119-t1x9gknd 4603 30 2 2 CD cord-010119-t1x9gknd 4603 31 King King NNP cord-010119-t1x9gknd 4603 32 Chulalongkorn Chulalongkorn NNP cord-010119-t1x9gknd 4603 33 Memorial Memorial NNP cord-010119-t1x9gknd 4603 34 Hospital Hospital NNP cord-010119-t1x9gknd 4603 35 , , , cord-010119-t1x9gknd 4603 36 3 3 CD cord-010119-t1x9gknd 4603 37 Prasat Prasat NNP cord-010119-t1x9gknd 4603 38 Neurological Neurological NNP cord-010119-t1x9gknd 4603 39 Institute Institute NNP cord-010119-t1x9gknd 4603 40 Background Background NNP cord-010119-t1x9gknd 4603 41 / / SYM cord-010119-t1x9gknd 4603 42 Case Case NNP cord-010119-t1x9gknd 4603 43 Studies Studies NNPS cord-010119-t1x9gknd 4603 44 : : : cord-010119-t1x9gknd 4603 45 Therapeutic therapeutic JJ cord-010119-t1x9gknd 4603 46 plasma plasma NN cord-010119-t1x9gknd 4603 47 exchange exchange NN cord-010119-t1x9gknd 4603 48 ( ( -LRB- cord-010119-t1x9gknd 4603 49 TPE TPE NNP cord-010119-t1x9gknd 4603 50 ) ) -RRB- cord-010119-t1x9gknd 4603 51 with with IN cord-010119-t1x9gknd 4603 52 albumin albumin NN cord-010119-t1x9gknd 4603 53 replacement replacement NN cord-010119-t1x9gknd 4603 54 has have VBZ cord-010119-t1x9gknd 4603 55 been be VBN cord-010119-t1x9gknd 4603 56 used use VBN cord-010119-t1x9gknd 4603 57 to to TO cord-010119-t1x9gknd 4603 58 treat treat VB cord-010119-t1x9gknd 4603 59 a a DT cord-010119-t1x9gknd 4603 60 variety variety NN cord-010119-t1x9gknd 4603 61 of of IN cord-010119-t1x9gknd 4603 62 diseases disease NNS cord-010119-t1x9gknd 4603 63 . . . cord-010119-t1x9gknd 4604 1 However however RB cord-010119-t1x9gknd 4604 2 , , , cord-010119-t1x9gknd 4604 3 there there EX cord-010119-t1x9gknd 4604 4 had have VBD cord-010119-t1x9gknd 4604 5 been be VBN cord-010119-t1x9gknd 4604 6 rising rise VBG cord-010119-t1x9gknd 4604 7 cost cost NN cord-010119-t1x9gknd 4604 8 and and CC cord-010119-t1x9gknd 4604 9 supply supply NN cord-010119-t1x9gknd 4604 10 shortage shortage NN cord-010119-t1x9gknd 4604 11 of of IN cord-010119-t1x9gknd 4604 12 imported import VBN cord-010119-t1x9gknd 4604 13 albumin albumin NN cord-010119-t1x9gknd 4604 14 in in IN cord-010119-t1x9gknd 4604 15 our -PRON- PRP$ cord-010119-t1x9gknd 4604 16 country country NN cord-010119-t1x9gknd 4604 17 . . . cord-010119-t1x9gknd 4605 1 To to TO cord-010119-t1x9gknd 4605 2 solve solve VB cord-010119-t1x9gknd 4605 3 the the DT cord-010119-t1x9gknd 4605 4 problem problem NN cord-010119-t1x9gknd 4605 5 , , , cord-010119-t1x9gknd 4605 6 our -PRON- PRP$ cord-010119-t1x9gknd 4605 7 National National NNP cord-010119-t1x9gknd 4605 8 Blood Blood NNP cord-010119-t1x9gknd 4605 9 Centre Centre NNP cord-010119-t1x9gknd 4605 10 had have VBD cord-010119-t1x9gknd 4605 11 established establish VBN cord-010119-t1x9gknd 4605 12 a a DT cord-010119-t1x9gknd 4605 13 plasma plasma NN cord-010119-t1x9gknd 4605 14 fractionation fractionation NN cord-010119-t1x9gknd 4605 15 plant plant NN cord-010119-t1x9gknd 4605 16 to to TO cord-010119-t1x9gknd 4605 17 manufacture manufacture VB cord-010119-t1x9gknd 4605 18 plasma plasma NN cord-010119-t1x9gknd 4605 19 derivatives derivative NNS cord-010119-t1x9gknd 4605 20 including include VBG cord-010119-t1x9gknd 4605 21 albumin albumin NN cord-010119-t1x9gknd 4605 22 . . . cord-010119-t1x9gknd 4606 1 The the DT cord-010119-t1x9gknd 4606 2 objective objective NN cord-010119-t1x9gknd 4606 3 of of IN cord-010119-t1x9gknd 4606 4 the the DT cord-010119-t1x9gknd 4606 5 study study NN cord-010119-t1x9gknd 4606 6 was be VBD cord-010119-t1x9gknd 4606 7 to to TO cord-010119-t1x9gknd 4606 8 evaluate evaluate VB cord-010119-t1x9gknd 4606 9 the the DT cord-010119-t1x9gknd 4606 10 safety safety NN cord-010119-t1x9gknd 4606 11 and and CC cord-010119-t1x9gknd 4606 12 efficacy efficacy NN cord-010119-t1x9gknd 4606 13 of of IN cord-010119-t1x9gknd 4606 14 local local JJ cord-010119-t1x9gknd 4606 15 albumin albumin NN cord-010119-t1x9gknd 4606 16 as as IN cord-010119-t1x9gknd 4606 17 a a DT cord-010119-t1x9gknd 4606 18 replacement replacement NN cord-010119-t1x9gknd 4606 19 for for IN cord-010119-t1x9gknd 4606 20 TPE TPE NNP cord-010119-t1x9gknd 4606 21 . . . cord-010119-t1x9gknd 4607 1 Study Study NNP cord-010119-t1x9gknd 4607 2 Design Design NNP cord-010119-t1x9gknd 4607 3 / / SYM cord-010119-t1x9gknd 4607 4 Method method NN cord-010119-t1x9gknd 4607 5 : : : cord-010119-t1x9gknd 4608 1 All all DT cord-010119-t1x9gknd 4608 2 TPEs tpe NNS cord-010119-t1x9gknd 4608 3 using use VBG cord-010119-t1x9gknd 4608 4 local local JJ cord-010119-t1x9gknd 4608 5 albumin albumin NN cord-010119-t1x9gknd 4608 6 as as IN cord-010119-t1x9gknd 4608 7 a a DT cord-010119-t1x9gknd 4608 8 replacement replacement NN cord-010119-t1x9gknd 4608 9 from from IN cord-010119-t1x9gknd 4608 10 two two CD cord-010119-t1x9gknd 4608 11 tertiary tertiary JJ cord-010119-t1x9gknd 4608 12 care care NN cord-010119-t1x9gknd 4608 13 hospitals hospital NNS cord-010119-t1x9gknd 4608 14 performed perform VBN cord-010119-t1x9gknd 4608 15 from from IN cord-010119-t1x9gknd 4608 16 June June NNP cord-010119-t1x9gknd 4608 17 2016 2016 CD cord-010119-t1x9gknd 4608 18 through through IN cord-010119-t1x9gknd 4608 19 February February NNP cord-010119-t1x9gknd 4608 20 2017 2017 CD cord-010119-t1x9gknd 4608 21 were be VBD cord-010119-t1x9gknd 4608 22 included include VBN cord-010119-t1x9gknd 4608 23 . . . cord-010119-t1x9gknd 4609 1 Complete complete JJ cord-010119-t1x9gknd 4609 2 blood blood NN cord-010119-t1x9gknd 4609 3 count count NN cord-010119-t1x9gknd 4609 4 and and CC cord-010119-t1x9gknd 4609 5 serum serum NN cord-010119-t1x9gknd 4609 6 calcium calcium NN cord-010119-t1x9gknd 4609 7 were be VBD cord-010119-t1x9gknd 4609 8 tested test VBN cord-010119-t1x9gknd 4609 9 before before IN cord-010119-t1x9gknd 4609 10 TPE TPE NNP cord-010119-t1x9gknd 4609 11 . . . cord-010119-t1x9gknd 4610 1 Serum serum NN cord-010119-t1x9gknd 4610 2 albumin albumin NN cord-010119-t1x9gknd 4610 3 was be VBD cord-010119-t1x9gknd 4610 4 tested test VBN cord-010119-t1x9gknd 4610 5 before before IN cord-010119-t1x9gknd 4610 6 and and CC cord-010119-t1x9gknd 4610 7 after after IN cord-010119-t1x9gknd 4610 8 TPE TPE NNP cord-010119-t1x9gknd 4610 9 . . . cord-010119-t1x9gknd 4611 1 Local local JJ cord-010119-t1x9gknd 4611 2 albumin albumin NN cord-010119-t1x9gknd 4611 3 is be VBZ cord-010119-t1x9gknd 4611 4 available available JJ cord-010119-t1x9gknd 4611 5 as as IN cord-010119-t1x9gknd 4611 6 a a DT cord-010119-t1x9gknd 4611 7 20 20 CD cord-010119-t1x9gknd 4611 8 % % NN cord-010119-t1x9gknd 4611 9 solution solution NN cord-010119-t1x9gknd 4611 10 . . . cord-010119-t1x9gknd 4612 1 Before before IN cord-010119-t1x9gknd 4612 2 using use VBG cord-010119-t1x9gknd 4612 3 , , , cord-010119-t1x9gknd 4612 4 it -PRON- PRP cord-010119-t1x9gknd 4612 5 was be VBD cord-010119-t1x9gknd 4612 6 diluted dilute VBN cord-010119-t1x9gknd 4612 7 to to IN cord-010119-t1x9gknd 4612 8 a a DT cord-010119-t1x9gknd 4612 9 4 4 CD cord-010119-t1x9gknd 4612 10 % % NN cord-010119-t1x9gknd 4612 11 albumin albumin NN cord-010119-t1x9gknd 4612 12 concentration concentration NN cord-010119-t1x9gknd 4612 13 with with IN cord-010119-t1x9gknd 4612 14 normal normal JJ cord-010119-t1x9gknd 4612 15 saline saline NN cord-010119-t1x9gknd 4612 16 . . . cord-010119-t1x9gknd 4613 1 All all PDT cord-010119-t1x9gknd 4613 2 the the DT cord-010119-t1x9gknd 4613 3 patients patient NNS cord-010119-t1x9gknd 4613 4 were be VBD cord-010119-t1x9gknd 4613 5 hospitalized hospitalize VBN cord-010119-t1x9gknd 4613 6 and and CC cord-010119-t1x9gknd 4613 7 received receive VBD cord-010119-t1x9gknd 4613 8 oral oral JJ cord-010119-t1x9gknd 4613 9 calcium calcium NN cord-010119-t1x9gknd 4613 10 before before IN cord-010119-t1x9gknd 4613 11 TPE TPE NNP cord-010119-t1x9gknd 4613 12 to to TO cord-010119-t1x9gknd 4613 13 prevent prevent VB cord-010119-t1x9gknd 4613 14 hypocalcemia hypocalcemia NN cord-010119-t1x9gknd 4613 15 . . . cord-010119-t1x9gknd 4614 1 The the DT cord-010119-t1x9gknd 4614 2 adverse adverse JJ cord-010119-t1x9gknd 4614 3 effects effect NNS cord-010119-t1x9gknd 4614 4 were be VBD cord-010119-t1x9gknd 4614 5 recorded record VBN cord-010119-t1x9gknd 4614 6 . . . cord-010119-t1x9gknd 4615 1 Results/ Results/ . cord-010119-t1x9gknd 4616 1 Finding finding NN cord-010119-t1x9gknd 4616 2 : : : cord-010119-t1x9gknd 4617 1 The the DT cord-010119-t1x9gknd 4617 2 total total NN cord-010119-t1x9gknd 4617 3 of of IN cord-010119-t1x9gknd 4617 4 156 156 CD cord-010119-t1x9gknd 4617 5 TPEs tpe NNS cord-010119-t1x9gknd 4617 6 in in IN cord-010119-t1x9gknd 4617 7 38 38 CD cord-010119-t1x9gknd 4617 8 patients patient NNS cord-010119-t1x9gknd 4617 9 were be VBD cord-010119-t1x9gknd 4617 10 included include VBN cord-010119-t1x9gknd 4617 11 as as IN cord-010119-t1x9gknd 4617 12 shown show VBN cord-010119-t1x9gknd 4617 13 in in IN cord-010119-t1x9gknd 4617 14 the the DT cord-010119-t1x9gknd 4617 15 Table table NN cord-010119-t1x9gknd 4617 16 . . . cord-010119-t1x9gknd 4618 1 Neurologic neurologic JJ cord-010119-t1x9gknd 4618 2 disorders disorder NNS cord-010119-t1x9gknd 4618 3 were be VBD cord-010119-t1x9gknd 4618 4 the the DT cord-010119-t1x9gknd 4618 5 most most RBS cord-010119-t1x9gknd 4618 6 common common JJ cord-010119-t1x9gknd 4618 7 indication indication NN cord-010119-t1x9gknd 4618 8 for for IN cord-010119-t1x9gknd 4618 9 TPE TPE NNP cord-010119-t1x9gknd 4618 10 , , , cord-010119-t1x9gknd 4618 11 followed follow VBN cord-010119-t1x9gknd 4618 12 by by IN cord-010119-t1x9gknd 4618 13 autoimmune autoimmune JJ cord-010119-t1x9gknd 4618 14 diseases disease NNS cord-010119-t1x9gknd 4618 15 . . . cord-010119-t1x9gknd 4619 1 The the DT cord-010119-t1x9gknd 4619 2 median median JJ cord-010119-t1x9gknd 4619 3 total total JJ cord-010119-t1x9gknd 4619 4 plasma plasma NN cord-010119-t1x9gknd 4619 5 volume volume NN cord-010119-t1x9gknd 4619 6 was be VBD cord-010119-t1x9gknd 4619 7 3,000 3,000 CD cord-010119-t1x9gknd 4619 8 ( ( -LRB- cord-010119-t1x9gknd 4619 9 range range VB cord-010119-t1x9gknd 4619 10 1,750 1,750 CD cord-010119-t1x9gknd 4619 11 - - HYPH cord-010119-t1x9gknd 4619 12 4,200 4,200 CD cord-010119-t1x9gknd 4619 13 ) ) -RRB- cord-010119-t1x9gknd 4620 1 mL. mL. NNP cord-010119-t1x9gknd 4621 1 Although although IN cord-010119-t1x9gknd 4621 2 the the DT cord-010119-t1x9gknd 4621 3 corrected correct VBN cord-010119-t1x9gknd 4621 4 calcium calcium NN cord-010119-t1x9gknd 4621 5 level level NN cord-010119-t1x9gknd 4621 6 was be VBD cord-010119-t1x9gknd 4621 7 low low JJ cord-010119-t1x9gknd 4621 8 ( ( -LRB- cord-010119-t1x9gknd 4621 9 < < NNP cord-010119-t1x9gknd 4621 10 8 8 CD cord-010119-t1x9gknd 4621 11 mg mg NNP cord-010119-t1x9gknd 4621 12 / / SYM cord-010119-t1x9gknd 4621 13 dL dl NN cord-010119-t1x9gknd 4621 14 ) ) -RRB- cord-010119-t1x9gknd 4621 15 in in IN cord-010119-t1x9gknd 4621 16 3.2 3.2 CD cord-010119-t1x9gknd 4621 17 % % NN cord-010119-t1x9gknd 4621 18 ( ( -LRB- cord-010119-t1x9gknd 4621 19 5/156 5/156 CD cord-010119-t1x9gknd 4621 20 ) ) -RRB- cord-010119-t1x9gknd 4621 21 before before IN cord-010119-t1x9gknd 4621 22 the the DT cord-010119-t1x9gknd 4621 23 procedure procedure NN cord-010119-t1x9gknd 4621 24 , , , cord-010119-t1x9gknd 4621 25 no no DT cord-010119-t1x9gknd 4621 26 clinical clinical JJ cord-010119-t1x9gknd 4621 27 manifestation manifestation NN cord-010119-t1x9gknd 4621 28 of of IN cord-010119-t1x9gknd 4621 29 hypocalcemia hypocalcemia NN cord-010119-t1x9gknd 4621 30 was be VBD cord-010119-t1x9gknd 4621 31 detected detect VBN cord-010119-t1x9gknd 4621 32 . . . cord-010119-t1x9gknd 4622 1 Adverse adverse JJ cord-010119-t1x9gknd 4622 2 effects effect NNS cord-010119-t1x9gknd 4622 3 were be VBD cord-010119-t1x9gknd 4622 4 observed observe VBN cord-010119-t1x9gknd 4622 5 during during IN cord-010119-t1x9gknd 4622 6 the the DT cord-010119-t1x9gknd 4622 7 TPE TPE NNP cord-010119-t1x9gknd 4622 8 procedure procedure NN cord-010119-t1x9gknd 4622 9 in in IN cord-010119-t1x9gknd 4622 10 2 2 CD cord-010119-t1x9gknd 4622 11 patients patient NNS cord-010119-t1x9gknd 4622 12 . . . cord-010119-t1x9gknd 4623 1 The the DT cord-010119-t1x9gknd 4623 2 first first JJ cord-010119-t1x9gknd 4623 3 patient patient NN cord-010119-t1x9gknd 4623 4 had have VBD cord-010119-t1x9gknd 4623 5 2 2 CD cord-010119-t1x9gknd 4623 6 events event NNS cord-010119-t1x9gknd 4623 7 of of IN cord-010119-t1x9gknd 4623 8 mild mild JJ cord-010119-t1x9gknd 4623 9 symptomatic symptomatic JJ cord-010119-t1x9gknd 4623 10 hypotension hypotension NN cord-010119-t1x9gknd 4623 11 . . . cord-010119-t1x9gknd 4624 1 He -PRON- PRP cord-010119-t1x9gknd 4624 2 previously previously RB cord-010119-t1x9gknd 4624 3 took take VBD cord-010119-t1x9gknd 4624 4 angiotensin angiotensin JJ cord-010119-t1x9gknd 4624 5 converting convert VBG cord-010119-t1x9gknd 4624 6 enzyme enzyme NN cord-010119-t1x9gknd 4624 7 inhibitor inhibitor NN cord-010119-t1x9gknd 4624 8 . . . cord-010119-t1x9gknd 4625 1 The the DT cord-010119-t1x9gknd 4625 2 second second JJ cord-010119-t1x9gknd 4625 3 patient patient NN cord-010119-t1x9gknd 4625 4 complained complain VBD cord-010119-t1x9gknd 4625 5 nausea nausea NN cord-010119-t1x9gknd 4625 6 after after IN cord-010119-t1x9gknd 4625 7 finishing finish VBG cord-010119-t1x9gknd 4625 8 TPE TPE NNP cord-010119-t1x9gknd 4625 9 . . . cord-010119-t1x9gknd 4626 1 All all DT cord-010119-t1x9gknd 4626 2 reactions reaction NNS cord-010119-t1x9gknd 4626 3 were be VBD cord-010119-t1x9gknd 4626 4 mild mild JJ cord-010119-t1x9gknd 4626 5 . . . cord-010119-t1x9gknd 4627 1 The the DT cord-010119-t1x9gknd 4627 2 incidence incidence NN cord-010119-t1x9gknd 4627 3 of of IN cord-010119-t1x9gknd 4627 4 adverse adverse JJ cord-010119-t1x9gknd 4627 5 effects effect NNS cord-010119-t1x9gknd 4627 6 was be VBD cord-010119-t1x9gknd 4627 7 1.9 1.9 CD cord-010119-t1x9gknd 4627 8 % % NN cord-010119-t1x9gknd 4627 9 ( ( -LRB- cord-010119-t1x9gknd 4627 10 3/ 3/ CD cord-010119-t1x9gknd 4627 11 156 156 CD cord-010119-t1x9gknd 4627 12 ) ) -RRB- cord-010119-t1x9gknd 4627 13 . . . cord-010119-t1x9gknd 4628 1 In in IN cord-010119-t1x9gknd 4628 2 2014 2014 CD cord-010119-t1x9gknd 4628 3 , , , cord-010119-t1x9gknd 4628 4 the the DT cord-010119-t1x9gknd 4628 5 incidence incidence NN cord-010119-t1x9gknd 4628 6 of of IN cord-010119-t1x9gknd 4628 7 TPE TPE NNP cord-010119-t1x9gknd 4628 8 adverse adverse JJ cord-010119-t1x9gknd 4628 9 effects effect NNS cord-010119-t1x9gknd 4628 10 was be VBD cord-010119-t1x9gknd 4628 11 1.6 1.6 CD cord-010119-t1x9gknd 4628 12 % % NN cord-010119-t1x9gknd 4628 13 ( ( -LRB- cord-010119-t1x9gknd 4628 14 2/125 2/125 CD cord-010119-t1x9gknd 4628 15 ) ) -RRB- cord-010119-t1x9gknd 4628 16 when when WRB cord-010119-t1x9gknd 4628 17 commercial commercial JJ cord-010119-t1x9gknd 4628 18 albumin albumin NN cord-010119-t1x9gknd 4628 19 was be VBD cord-010119-t1x9gknd 4628 20 used use VBN cord-010119-t1x9gknd 4628 21 . . . cord-010119-t1x9gknd 4629 1 The the DT cord-010119-t1x9gknd 4629 2 difference difference NN cord-010119-t1x9gknd 4629 3 was be VBD cord-010119-t1x9gknd 4629 4 not not RB cord-010119-t1x9gknd 4629 5 statistically statistically RB cord-010119-t1x9gknd 4629 6 different different JJ cord-010119-t1x9gknd 4629 7 ( ( -LRB- cord-010119-t1x9gknd 4629 8 P p NN cord-010119-t1x9gknd 4629 9 5 5 CD cord-010119-t1x9gknd 4629 10 1.000 1.000 CD cord-010119-t1x9gknd 4629 11 ) ) -RRB- cord-010119-t1x9gknd 4629 12 . . . cord-010119-t1x9gknd 4630 1 Median median JJ cord-010119-t1x9gknd 4630 2 serum serum NN cord-010119-t1x9gknd 4630 3 albumin albumin NN cord-010119-t1x9gknd 4630 4 levels level NNS cord-010119-t1x9gknd 4631 1 pre pre JJ cord-010119-t1x9gknd 4631 2 - - NNP cord-010119-t1x9gknd 4631 3 TPE TPE NNP cord-010119-t1x9gknd 4631 4 and and CC cord-010119-t1x9gknd 4631 5 post post JJ cord-010119-t1x9gknd 4631 6 - - NN cord-010119-t1x9gknd 4631 7 TPE TPE NNP cord-010119-t1x9gknd 4631 8 were be VBD cord-010119-t1x9gknd 4631 9 3.6 3.6 CD cord-010119-t1x9gknd 4631 10 ( ( -LRB- cord-010119-t1x9gknd 4631 11 1.9 1.9 CD cord-010119-t1x9gknd 4631 12 - - SYM cord-010119-t1x9gknd 4631 13 4.4 4.4 CD cord-010119-t1x9gknd 4631 14 ) ) -RRB- cord-010119-t1x9gknd 4631 15 and and CC cord-010119-t1x9gknd 4631 16 3.9 3.9 CD cord-010119-t1x9gknd 4631 17 ( ( -LRB- cord-010119-t1x9gknd 4631 18 2.4 2.4 CD cord-010119-t1x9gknd 4631 19 - - SYM cord-010119-t1x9gknd 4631 20 5.0 5.0 CD cord-010119-t1x9gknd 4631 21 ) ) -RRB- cord-010119-t1x9gknd 4632 1 g g NNP cord-010119-t1x9gknd 4632 2 / / SYM cord-010119-t1x9gknd 4632 3 dL. dL. NNP cord-010119-t1x9gknd 4633 1 The the DT cord-010119-t1x9gknd 4633 2 increase increase NN cord-010119-t1x9gknd 4633 3 in in IN cord-010119-t1x9gknd 4633 4 serum serum NN cord-010119-t1x9gknd 4633 5 albumin albumin NN cord-010119-t1x9gknd 4633 6 after after IN cord-010119-t1x9gknd 4633 7 TPE TPE NNP cord-010119-t1x9gknd 4633 8 was be VBD cord-010119-t1x9gknd 4633 9 statistically statistically RB cord-010119-t1x9gknd 4633 10 significant significant JJ cord-010119-t1x9gknd 4633 11 ( ( -LRB- cord-010119-t1x9gknd 4633 12 p<0.001 p<0.001 JJ cord-010119-t1x9gknd 4633 13 ) ) -RRB- cord-010119-t1x9gknd 4633 14 . . . cord-010119-t1x9gknd 4634 1 Eighty eighty CD cord-010119-t1x9gknd 4634 2 - - HYPH cord-010119-t1x9gknd 4634 3 two two CD cord-010119-t1x9gknd 4634 4 percent percent NN cord-010119-t1x9gknd 4634 5 of of IN cord-010119-t1x9gknd 4634 6 pre pre JJ cord-010119-t1x9gknd 4634 7 - - JJ cord-010119-t1x9gknd 4634 8 TPE TPE NNP cord-010119-t1x9gknd 4634 9 serum serum NN cord-010119-t1x9gknd 4634 10 albumin albumin NN cord-010119-t1x9gknd 4634 11 levels level NNS cord-010119-t1x9gknd 4634 12 were be VBD cord-010119-t1x9gknd 4634 13 lower low JJR cord-010119-t1x9gknd 4634 14 than than IN cord-010119-t1x9gknd 4634 15 4.0 4.0 CD cord-010119-t1x9gknd 4634 16 g g NN cord-010119-t1x9gknd 4634 17 / / SYM cord-010119-t1x9gknd 4634 18 dL dl NN cord-010119-t1x9gknd 4634 19 explaining explain VBG cord-010119-t1x9gknd 4634 20 the the DT cord-010119-t1x9gknd 4634 21 rises rise NNS cord-010119-t1x9gknd 4634 22 of of IN cord-010119-t1x9gknd 4634 23 albumin albumin NN cord-010119-t1x9gknd 4634 24 after after IN cord-010119-t1x9gknd 4634 25 the the DT cord-010119-t1x9gknd 4634 26 procedures procedure NNS cord-010119-t1x9gknd 4634 27 . . . cord-010119-t1x9gknd 4635 1 We -PRON- PRP cord-010119-t1x9gknd 4635 2 demonstrated demonstrate VBD cord-010119-t1x9gknd 4635 3 that that IN cord-010119-t1x9gknd 4635 4 local local JJ cord-010119-t1x9gknd 4635 5 albumin albumin NN cord-010119-t1x9gknd 4635 6 was be VBD cord-010119-t1x9gknd 4635 7 safe safe JJ cord-010119-t1x9gknd 4635 8 and and CC cord-010119-t1x9gknd 4635 9 effective effective JJ cord-010119-t1x9gknd 4635 10 in in IN cord-010119-t1x9gknd 4635 11 maintaining maintain VBG cord-010119-t1x9gknd 4635 12 albumin albumin NN cord-010119-t1x9gknd 4635 13 levels level NNS cord-010119-t1x9gknd 4635 14 in in IN cord-010119-t1x9gknd 4635 15 patients patient NNS cord-010119-t1x9gknd 4635 16 undergoing undergo VBG cord-010119-t1x9gknd 4635 17 TPEs tpe NNS cord-010119-t1x9gknd 4635 18 . . . cord-010119-t1x9gknd 4636 1 Safety safety NN cord-010119-t1x9gknd 4636 2 , , , cord-010119-t1x9gknd 4636 3 Efficancy Efficancy NNP cord-010119-t1x9gknd 4636 4 and and CC cord-010119-t1x9gknd 4636 5 Cost Cost NNP cord-010119-t1x9gknd 4636 6 - - HYPH cord-010119-t1x9gknd 4636 7 Effectiveness Effectiveness NNP cord-010119-t1x9gknd 4636 8 of of IN cord-010119-t1x9gknd 4636 9 Mononuclear Mononuclear NNP cord-010119-t1x9gknd 4636 10 Cell Cell NNP cord-010119-t1x9gknd 4636 11 Collections collection NNS cord-010119-t1x9gknd 4636 12 for for IN cord-010119-t1x9gknd 4636 13 Autologous autologous JJ cord-010119-t1x9gknd 4636 14 Immunotherapies immunotherapy NNS cord-010119-t1x9gknd 4636 15 : : : cord-010119-t1x9gknd 4636 16 Experience experience NN cord-010119-t1x9gknd 4636 17 from from IN cord-010119-t1x9gknd 4636 18 a a DT cord-010119-t1x9gknd 4636 19 Private Private NNP cord-010119-t1x9gknd 4636 20 Outpatient Outpatient NNP cord-010119-t1x9gknd 4636 21 Collection Collection NNP cord-010119-t1x9gknd 4636 22 Facility Facility NNP cord-010119-t1x9gknd 4636 23 within within IN cord-010119-t1x9gknd 4636 24 the the DT cord-010119-t1x9gknd 4636 25 EU EU NNP cord-010119-t1x9gknd 4636 26 Markus Markus NNP cord-010119-t1x9gknd 4636 27 Dettke Dettke NNP cord-010119-t1x9gknd 4637 1 * * NFP cord-010119-t1x9gknd 4637 2 . . . cord-010119-t1x9gknd 4638 1 AKH AKH NNP cord-010119-t1x9gknd 4638 2 Vienna Vienna NNP cord-010119-t1x9gknd 4638 3 University University NNP cord-010119-t1x9gknd 4638 4 Hospital Hospital NNP cord-010119-t1x9gknd 4638 5 , , , cord-010119-t1x9gknd 4638 6 Cyto-Care.eu Cyto-Care.eu NNP cord-010119-t1x9gknd 4639 1 Background Background NNP cord-010119-t1x9gknd 4639 2 / / SYM cord-010119-t1x9gknd 4639 3 Case Case NNP cord-010119-t1x9gknd 4639 4 Studies Studies NNPS cord-010119-t1x9gknd 4639 5 : : : cord-010119-t1x9gknd 4640 1 Within within IN cord-010119-t1x9gknd 4640 2 the the DT cord-010119-t1x9gknd 4640 3 EU EU NNP cord-010119-t1x9gknd 4640 4 the the DT cord-010119-t1x9gknd 4640 5 collection collection NN cord-010119-t1x9gknd 4640 6 of of IN cord-010119-t1x9gknd 4640 7 mononuclear mononuclear JJ cord-010119-t1x9gknd 4640 8 cells cell NNS cord-010119-t1x9gknd 4640 9 ( ( -LRB- cord-010119-t1x9gknd 4640 10 MNC MNC NNP cord-010119-t1x9gknd 4640 11 ) ) -RRB- cord-010119-t1x9gknd 4640 12 as as IN cord-010119-t1x9gknd 4640 13 starting start VBG cord-010119-t1x9gknd 4640 14 source source NN cord-010119-t1x9gknd 4640 15 for for IN cord-010119-t1x9gknd 4640 16 the the DT cord-010119-t1x9gknd 4640 17 manufacturing manufacturing NN cord-010119-t1x9gknd 4640 18 of of IN cord-010119-t1x9gknd 4640 19 autologous autologous JJ cord-010119-t1x9gknd 4640 20 cell cell NN cord-010119-t1x9gknd 4640 21 therapies therapy NNS cord-010119-t1x9gknd 4640 22 are be VBP cord-010119-t1x9gknd 4640 23 mainly mainly RB cord-010119-t1x9gknd 4640 24 performed perform VBN cord-010119-t1x9gknd 4640 25 in in IN cord-010119-t1x9gknd 4640 26 hospitals hospital NNS cord-010119-t1x9gknd 4640 27 or or CC cord-010119-t1x9gknd 4640 28 hospital hospital NN cord-010119-t1x9gknd 4640 29 - - HYPH cord-010119-t1x9gknd 4640 30 associated associate VBN cord-010119-t1x9gknd 4640 31 apheresis apheresis NN cord-010119-t1x9gknd 4640 32 centers center NNS cord-010119-t1x9gknd 4640 33 . . . cord-010119-t1x9gknd 4641 1 We -PRON- PRP cord-010119-t1x9gknd 4641 2 report report VBP cord-010119-t1x9gknd 4641 3 about about IN cord-010119-t1x9gknd 4641 4 the the DT cord-010119-t1x9gknd 4641 5 challenges challenge NNS cord-010119-t1x9gknd 4641 6 to to TO cord-010119-t1x9gknd 4641 7 perform perform VB cord-010119-t1x9gknd 4641 8 the the DT cord-010119-t1x9gknd 4641 9 leukapheresis leukapheresis NN cord-010119-t1x9gknd 4641 10 procedure procedure NN cord-010119-t1x9gknd 4641 11 ( ( -LRB- cord-010119-t1x9gknd 4641 12 LA LA NNP cord-010119-t1x9gknd 4641 13 ) ) -RRB- cord-010119-t1x9gknd 4641 14 at at IN cord-010119-t1x9gknd 4641 15 a a DT cord-010119-t1x9gknd 4641 16 private private JJ cord-010119-t1x9gknd 4641 17 held hold VBN cord-010119-t1x9gknd 4641 18 medical medical JJ cord-010119-t1x9gknd 4641 19 practice practice NN cord-010119-t1x9gknd 4641 20 , , , cord-010119-t1x9gknd 4641 21 with with IN cord-010119-t1x9gknd 4641 22 specific specific JJ cord-010119-t1x9gknd 4641 23 emphases emphasis NNS cord-010119-t1x9gknd 4641 24 on on IN cord-010119-t1x9gknd 4641 25 safety safety NN cord-010119-t1x9gknd 4641 26 , , , cord-010119-t1x9gknd 4641 27 cell cell NN cord-010119-t1x9gknd 4641 28 collection collection NN cord-010119-t1x9gknd 4641 29 efficiency efficiency NN cord-010119-t1x9gknd 4641 30 , , , cord-010119-t1x9gknd 4641 31 and and CC cord-010119-t1x9gknd 4641 32 cost cost NN cord-010119-t1x9gknd 4641 33 - - HYPH cord-010119-t1x9gknd 4641 34 effectiveness effectiveness NN cord-010119-t1x9gknd 4641 35 . . . cord-010119-t1x9gknd 4642 1 Study Study NNP cord-010119-t1x9gknd 4642 2 Design Design NNP cord-010119-t1x9gknd 4642 3 / / SYM cord-010119-t1x9gknd 4642 4 Method method NN cord-010119-t1x9gknd 4642 5 : : : cord-010119-t1x9gknd 4642 6 We -PRON- PRP cord-010119-t1x9gknd 4642 7 reviewed review VBD cord-010119-t1x9gknd 4642 8 the the DT cord-010119-t1x9gknd 4642 9 records record NNS cord-010119-t1x9gknd 4642 10 of of IN cord-010119-t1x9gknd 4642 11 altogether altogether RB cord-010119-t1x9gknd 4642 12 60 60 CD cord-010119-t1x9gknd 4642 13 outpatients outpatient NNS cord-010119-t1x9gknd 4642 14 who who WP cord-010119-t1x9gknd 4642 15 underwent undergo VBD cord-010119-t1x9gknd 4642 16 a a DT cord-010119-t1x9gknd 4642 17 total total NN cord-010119-t1x9gknd 4642 18 of of IN cord-010119-t1x9gknd 4642 19 100 100 CD cord-010119-t1x9gknd 4642 20 LA LA NNP cord-010119-t1x9gknd 4642 21 procedure procedure NN cord-010119-t1x9gknd 4642 22 at at IN cord-010119-t1x9gknd 4642 23 Cyto Cyto NNP cord-010119-t1x9gknd 4642 24 - - HYPH cord-010119-t1x9gknd 4642 25 Care Care NNP cord-010119-t1x9gknd 4642 26 , , , cord-010119-t1x9gknd 4642 27 a a DT cord-010119-t1x9gknd 4642 28 private private JJ cord-010119-t1x9gknd 4642 29 held hold VBN cord-010119-t1x9gknd 4642 30 medical medical JJ cord-010119-t1x9gknd 4642 31 practice/ practice/ NNP cord-010119-t1x9gknd 4642 32 certified certified JJ cord-010119-t1x9gknd 4642 33 cell cell NN cord-010119-t1x9gknd 4642 34 collection collection NN cord-010119-t1x9gknd 4642 35 facility facility NN cord-010119-t1x9gknd 4642 36 located locate VBN cord-010119-t1x9gknd 4642 37 in in IN cord-010119-t1x9gknd 4642 38 Vienna Vienna NNP cord-010119-t1x9gknd 4642 39 , , , cord-010119-t1x9gknd 4642 40 Austria Austria NNP cord-010119-t1x9gknd 4642 41 . . . cord-010119-t1x9gknd 4643 1 All all DT cord-010119-t1x9gknd 4643 2 patients patient NNS cord-010119-t1x9gknd 4643 3 participated participate VBD cord-010119-t1x9gknd 4643 4 in in IN cord-010119-t1x9gknd 4643 5 various various JJ cord-010119-t1x9gknd 4643 6 industry industry NN cord-010119-t1x9gknd 4643 7 - - HYPH cord-010119-t1x9gknd 4643 8 sponsored sponsor VBN cord-010119-t1x9gknd 4643 9 clinical clinical JJ cord-010119-t1x9gknd 4643 10 P P NNP cord-010119-t1x9gknd 4643 11 I I NNP cord-010119-t1x9gknd 4643 12 - - HYPH cord-010119-t1x9gknd 4643 13 III iii CD cord-010119-t1x9gknd 4643 14 trials trial NNS cord-010119-t1x9gknd 4643 15 ; ; : cord-010119-t1x9gknd 4643 16 the the DT cord-010119-t1x9gknd 4643 17 study study NN cord-010119-t1x9gknd 4643 18 sponsors sponsor NNS cord-010119-t1x9gknd 4643 19 were be VBD cord-010119-t1x9gknd 4643 20 responsible responsible JJ cord-010119-t1x9gknd 4643 21 for for IN cord-010119-t1x9gknd 4643 22 the the DT cord-010119-t1x9gknd 4643 23 manufacturing manufacturing NN cord-010119-t1x9gknd 4643 24 of of IN cord-010119-t1x9gknd 4643 25 the the DT cord-010119-t1x9gknd 4643 26 active active JJ cord-010119-t1x9gknd 4643 27 cell cell NN cord-010119-t1x9gknd 4643 28 product product NN cord-010119-t1x9gknd 4643 29 . . . cord-010119-t1x9gknd 4644 1 Disease Disease NNP cord-010119-t1x9gknd 4644 2 entities entity NNS cord-010119-t1x9gknd 4644 3 were be VBD cord-010119-t1x9gknd 4644 4 mainly mainly RB cord-010119-t1x9gknd 4644 5 prostatic prostatic JJ cord-010119-t1x9gknd 4644 6 cancer cancer NN cord-010119-t1x9gknd 4644 7 ( ( -LRB- cord-010119-t1x9gknd 4644 8 75 75 CD cord-010119-t1x9gknd 4644 9 % % NN cord-010119-t1x9gknd 4644 10 ) ) -RRB- cord-010119-t1x9gknd 4644 11 and and CC cord-010119-t1x9gknd 4644 12 ovarian ovarian JJ cord-010119-t1x9gknd 4644 13 cancer cancer NN cord-010119-t1x9gknd 4644 14 ( ( -LRB- cord-010119-t1x9gknd 4644 15 20 20 CD cord-010119-t1x9gknd 4644 16 % % NN cord-010119-t1x9gknd 4644 17 ) ) -RRB- cord-010119-t1x9gknd 4644 18 . . . cord-010119-t1x9gknd 4645 1 Based base VBN cord-010119-t1x9gknd 4645 2 on on IN cord-010119-t1x9gknd 4645 3 differences difference NNS cord-010119-t1x9gknd 4645 4 in in IN cord-010119-t1x9gknd 4645 5 the the DT cord-010119-t1x9gknd 4645 6 study study NN cord-010119-t1x9gknd 4645 7 protocols protocol NNS cord-010119-t1x9gknd 4645 8 LA LA NNP cord-010119-t1x9gknd 4645 9 was be VBD cord-010119-t1x9gknd 4645 10 performed perform VBN cord-010119-t1x9gknd 4645 11 either either CC cord-010119-t1x9gknd 4645 12 one one CD cord-010119-t1x9gknd 4645 13 - - HYPH cord-010119-t1x9gknd 4645 14 time time NN cord-010119-t1x9gknd 4645 15 ( ( -LRB- cord-010119-t1x9gknd 4645 16 41 41 CD cord-010119-t1x9gknd 4645 17 % % NN cord-010119-t1x9gknd 4645 18 ) ) -RRB- cord-010119-t1x9gknd 4645 19 , , , cord-010119-t1x9gknd 4645 20 two two CD cord-010119-t1x9gknd 4645 21 - - HYPH cord-010119-t1x9gknd 4645 22 times time NNS cord-010119-t1x9gknd 4645 23 ( ( -LRB- cord-010119-t1x9gknd 4645 24 27 27 CD cord-010119-t1x9gknd 4645 25 % % NN cord-010119-t1x9gknd 4645 26 ) ) -RRB- cord-010119-t1x9gknd 4645 27 or or CC cord-010119-t1x9gknd 4645 28 three three CD cord-010119-t1x9gknd 4645 29 - - HYPH cord-010119-t1x9gknd 4645 30 times time NNS cord-010119-t1x9gknd 4645 31 ( ( -LRB- cord-010119-t1x9gknd 4645 32 32 32 CD cord-010119-t1x9gknd 4645 33 % % NN cord-010119-t1x9gknd 4645 34 ) ) -RRB- cord-010119-t1x9gknd 4645 35 , , , cord-010119-t1x9gknd 4645 36 with with IN cord-010119-t1x9gknd 4645 37 an an DT cord-010119-t1x9gknd 4645 38 interval interval NN cord-010119-t1x9gknd 4645 39 of of IN cord-010119-t1x9gknd 4645 40 at at RB cord-010119-t1x9gknd 4645 41 least least JJS cord-010119-t1x9gknd 4645 42 2 2 CD cord-010119-t1x9gknd 4645 43 weeks week NNS cord-010119-t1x9gknd 4645 44 between between IN cord-010119-t1x9gknd 4645 45 repeated repeat VBN cord-010119-t1x9gknd 4645 46 collections collection NNS cord-010119-t1x9gknd 4645 47 . . . cord-010119-t1x9gknd 4646 1 Results result NNS cord-010119-t1x9gknd 4646 2 / / SYM cord-010119-t1x9gknd 4646 3 Finding finding NN cord-010119-t1x9gknd 4646 4 : : : cord-010119-t1x9gknd 4647 1 All all DT cord-010119-t1x9gknd 4647 2 patients patient NNS cord-010119-t1x9gknd 4647 3 successfully successfully RB cord-010119-t1x9gknd 4647 4 completed complete VBD cord-010119-t1x9gknd 4647 5 the the DT cord-010119-t1x9gknd 4647 6 apheresis apheresis NN cord-010119-t1x9gknd 4647 7 course course NN cord-010119-t1x9gknd 4647 8 . . . cord-010119-t1x9gknd 4648 1 Because because IN cord-010119-t1x9gknd 4648 2 of of IN cord-010119-t1x9gknd 4648 3 poor poor JJ cord-010119-t1x9gknd 4648 4 venous venous JJ cord-010119-t1x9gknd 4648 5 access access NN cord-010119-t1x9gknd 4648 6 , , , cord-010119-t1x9gknd 4648 7 3 3 CD cord-010119-t1x9gknd 4648 8 out out IN cord-010119-t1x9gknd 4648 9 of of IN cord-010119-t1x9gknd 4648 10 60 60 CD cord-010119-t1x9gknd 4648 11 patients patient NNS cord-010119-t1x9gknd 4648 12 ( ( -LRB- cord-010119-t1x9gknd 4648 13 5 5 CD cord-010119-t1x9gknd 4648 14 % % NN cord-010119-t1x9gknd 4648 15 ) ) -RRB- cord-010119-t1x9gknd 4648 16 required require VBD cord-010119-t1x9gknd 4648 17 a a DT cord-010119-t1x9gknd 4648 18 shortterm shortterm JJ cord-010119-t1x9gknd 4648 19 femoral femoral JJ cord-010119-t1x9gknd 4648 20 catheter catheter NN cord-010119-t1x9gknd 4648 21 insertion insertion NN cord-010119-t1x9gknd 4648 22 . . . cord-010119-t1x9gknd 4649 1 There there EX cord-010119-t1x9gknd 4649 2 were be VBD cord-010119-t1x9gknd 4649 3 no no DT cord-010119-t1x9gknd 4649 4 serious serious JJ cord-010119-t1x9gknd 4649 5 side side NN cord-010119-t1x9gknd 4649 6 effects effect NNS cord-010119-t1x9gknd 4649 7 in in IN cord-010119-t1x9gknd 4649 8 patients patient NNS cord-010119-t1x9gknd 4649 9 who who WP cord-010119-t1x9gknd 4649 10 required require VBD cord-010119-t1x9gknd 4649 11 a a DT cord-010119-t1x9gknd 4649 12 femoral femoral JJ cord-010119-t1x9gknd 4649 13 catheter catheter NN cord-010119-t1x9gknd 4649 14 , , , cord-010119-t1x9gknd 4649 15 or or CC cord-010119-t1x9gknd 4649 16 in in IN cord-010119-t1x9gknd 4649 17 patients patient NNS cord-010119-t1x9gknd 4649 18 with with IN cord-010119-t1x9gknd 4649 19 repeated repeat VBN cord-010119-t1x9gknd 4649 20 LA LA NNP cord-010119-t1x9gknd 4649 21 procedures procedure NNS cord-010119-t1x9gknd 4649 22 . . . cord-010119-t1x9gknd 4650 1 Side side JJ cord-010119-t1x9gknd 4650 2 effects effect NNS cord-010119-t1x9gknd 4650 3 of of IN cord-010119-t1x9gknd 4650 4 the the DT cord-010119-t1x9gknd 4650 5 LA LA NNP cord-010119-t1x9gknd 4650 6 procedure procedure NN cord-010119-t1x9gknd 4650 7 mainly mainly RB cord-010119-t1x9gknd 4650 8 consisted consist VBD cord-010119-t1x9gknd 4650 9 on on IN cord-010119-t1x9gknd 4650 10 mild mild JJ cord-010119-t1x9gknd 4650 11 hypocalcaemia hypocalcaemia NN cord-010119-t1x9gknd 4650 12 - - HYPH cord-010119-t1x9gknd 4650 13 related relate VBN cord-010119-t1x9gknd 4650 14 symptoms symptom NNS cord-010119-t1x9gknd 4650 15 in in IN cord-010119-t1x9gknd 4650 16 16 16 CD cord-010119-t1x9gknd 4650 17 % % NN cord-010119-t1x9gknd 4650 18 of of IN cord-010119-t1x9gknd 4650 19 patients patient NNS cord-010119-t1x9gknd 4650 20 . . . cord-010119-t1x9gknd 4651 1 A a DT cord-010119-t1x9gknd 4651 2 follow follow VB cord-010119-t1x9gknd 4651 3 - - HYPH cord-010119-t1x9gknd 4651 4 up up NN cord-010119-t1x9gknd 4651 5 survey survey NN cord-010119-t1x9gknd 4651 6 one one CD cord-010119-t1x9gknd 4651 7 week week NN cord-010119-t1x9gknd 4651 8 after after IN cord-010119-t1x9gknd 4651 9 completion completion NN cord-010119-t1x9gknd 4651 10 of of IN cord-010119-t1x9gknd 4651 11 the the DT cord-010119-t1x9gknd 4651 12 LA LA NNP cord-010119-t1x9gknd 4651 13 revealed reveal VBD cord-010119-t1x9gknd 4651 14 no no DT cord-010119-t1x9gknd 4651 15 infectious infectious JJ cord-010119-t1x9gknd 4651 16 complications complication NNS cord-010119-t1x9gknd 4651 17 , , , cord-010119-t1x9gknd 4651 18 and and CC cord-010119-t1x9gknd 4651 19 no no DT cord-010119-t1x9gknd 4651 20 patient patient NN cord-010119-t1x9gknd 4651 21 required require VBD cord-010119-t1x9gknd 4651 22 hospitalization hospitalization NN cord-010119-t1x9gknd 4651 23 . . . cord-010119-t1x9gknd 4652 1 Median median JJ cord-010119-t1x9gknd 4652 2 cell cell NN cord-010119-t1x9gknd 4652 3 yield yield NN cord-010119-t1x9gknd 4652 4 collected collect VBN cord-010119-t1x9gknd 4652 5 per per IN cord-010119-t1x9gknd 4652 6 single single JJ cord-010119-t1x9gknd 4652 7 apheresis apheresis NN cord-010119-t1x9gknd 4652 8 was be VBD cord-010119-t1x9gknd 4652 9 1.4x10 1.4x10 CD cord-010119-t1x9gknd 4652 10 10 10 CD cord-010119-t1x9gknd 4652 11 WBC WBC NNP cord-010119-t1x9gknd 4652 12 consisting consist VBG cord-010119-t1x9gknd 4652 13 of of IN cord-010119-t1x9gknd 4652 14 1.1x10 1.1x10 CD cord-010119-t1x9gknd 4652 15 10 10 CD cord-010119-t1x9gknd 4652 16 MNC MNC NNP cord-010119-t1x9gknd 4652 17 . . . cord-010119-t1x9gknd 4653 1 MNC MNC NNP cord-010119-t1x9gknd 4653 2 cell cell NN cord-010119-t1x9gknd 4653 3 yields yield NNS cord-010119-t1x9gknd 4653 4 remained remain VBD cord-010119-t1x9gknd 4653 5 stable stable JJ cord-010119-t1x9gknd 4653 6 even even RB cord-010119-t1x9gknd 4653 7 in in IN cord-010119-t1x9gknd 4653 8 repeated repeat VBN cord-010119-t1x9gknd 4653 9 LA LA NNP cord-010119-t1x9gknd 4653 10 collections collection NNS cord-010119-t1x9gknd 4653 11 . . . cord-010119-t1x9gknd 4654 1 All all DT cord-010119-t1x9gknd 4654 2 cell cell NN cord-010119-t1x9gknd 4654 3 products product NNS cord-010119-t1x9gknd 4654 4 were be VBD cord-010119-t1x9gknd 4654 5 successful successful JJ cord-010119-t1x9gknd 4654 6 transformed transform VBN cord-010119-t1x9gknd 4654 7 into into IN cord-010119-t1x9gknd 4654 8 an an DT cord-010119-t1x9gknd 4654 9 active active JJ cord-010119-t1x9gknd 4654 10 cellular cellular JJ cord-010119-t1x9gknd 4654 11 product product NN cord-010119-t1x9gknd 4654 12 . . . cord-010119-t1x9gknd 4655 1 Analysis analysis NN cord-010119-t1x9gknd 4655 2 of of IN cord-010119-t1x9gknd 4655 3 the the DT cord-010119-t1x9gknd 4655 4 cost cost NN cord-010119-t1x9gknd 4655 5 structure structure NN cord-010119-t1x9gknd 4655 6 showed show VBD cord-010119-t1x9gknd 4655 7 that that IN cord-010119-t1x9gknd 4655 8 the the DT cord-010119-t1x9gknd 4655 9 total total JJ cord-010119-t1x9gknd 4655 10 cost cost NN cord-010119-t1x9gknd 4655 11 of of IN cord-010119-t1x9gknd 4655 12 care care NN cord-010119-t1x9gknd 4655 13 was be VBD cord-010119-t1x9gknd 4655 14 32 32 CD cord-010119-t1x9gknd 4655 15 % % NN cord-010119-t1x9gknd 4655 16 lower low JJR cord-010119-t1x9gknd 4655 17 in in IN cord-010119-t1x9gknd 4655 18 the the DT cord-010119-t1x9gknd 4655 19 setting setting NN cord-010119-t1x9gknd 4655 20 of of IN cord-010119-t1x9gknd 4655 21 a a DT cord-010119-t1x9gknd 4655 22 private private JJ cord-010119-t1x9gknd 4655 23 collection collection NN cord-010119-t1x9gknd 4655 24 center center NN cord-010119-t1x9gknd 4655 25 compared compare VBN cord-010119-t1x9gknd 4655 26 to to IN cord-010119-t1x9gknd 4655 27 hospital hospital NN cord-010119-t1x9gknd 4655 28 - - HYPH cord-010119-t1x9gknd 4655 29 based base VBN cord-010119-t1x9gknd 4655 30 apheresis apheresis NN cord-010119-t1x9gknd 4655 31 centers center NNS cord-010119-t1x9gknd 4655 32 . . . cord-010119-t1x9gknd 4656 1 Conclusion conclusion NN cord-010119-t1x9gknd 4656 2 : : : cord-010119-t1x9gknd 4657 1 Leukapheresis leukapheresis NN cord-010119-t1x9gknd 4657 2 performed perform VBN cord-010119-t1x9gknd 4657 3 in in IN cord-010119-t1x9gknd 4657 4 a a DT cord-010119-t1x9gknd 4657 5 private private JJ cord-010119-t1x9gknd 4657 6 medical medical JJ cord-010119-t1x9gknd 4657 7 practice/ practice/ NNP cord-010119-t1x9gknd 4657 8 certified certified JJ cord-010119-t1x9gknd 4657 9 cell cell NN cord-010119-t1x9gknd 4657 10 collection collection NN cord-010119-t1x9gknd 4657 11 facility facility NN cord-010119-t1x9gknd 4657 12 is be VBZ cord-010119-t1x9gknd 4657 13 safe safe JJ cord-010119-t1x9gknd 4657 14 and and CC cord-010119-t1x9gknd 4657 15 effective effective JJ cord-010119-t1x9gknd 4657 16 , , , cord-010119-t1x9gknd 4657 17 with with IN cord-010119-t1x9gknd 4657 18 low low JJ cord-010119-t1x9gknd 4657 19 rates rate NNS cord-010119-t1x9gknd 4657 20 of of IN cord-010119-t1x9gknd 4657 21 complications complication NNS cord-010119-t1x9gknd 4657 22 and and CC cord-010119-t1x9gknd 4657 23 high high JJ cord-010119-t1x9gknd 4657 24 levels level NNS cord-010119-t1x9gknd 4657 25 of of IN cord-010119-t1x9gknd 4657 26 patient patient JJ cord-010119-t1x9gknd 4657 27 satisfaction satisfaction NN cord-010119-t1x9gknd 4657 28 . . . cord-010119-t1x9gknd 4658 1 This this DT cord-010119-t1x9gknd 4658 2 service service NN cord-010119-t1x9gknd 4658 3 model model NN cord-010119-t1x9gknd 4658 4 is be VBZ cord-010119-t1x9gknd 4658 5 costeffective costeffective JJ cord-010119-t1x9gknd 4658 6 and and CC cord-010119-t1x9gknd 4658 7 can can MD cord-010119-t1x9gknd 4658 8 help help VB cord-010119-t1x9gknd 4658 9 to to TO cord-010119-t1x9gknd 4658 10 reduce reduce VB cord-010119-t1x9gknd 4658 11 the the DT cord-010119-t1x9gknd 4658 12 cost cost NN cord-010119-t1x9gknd 4658 13 of of IN cord-010119-t1x9gknd 4658 14 manufactured manufacture VBN cord-010119-t1x9gknd 4658 15 goods good NNS cord-010119-t1x9gknd 4658 16 in in IN cord-010119-t1x9gknd 4658 17 the the DT cord-010119-t1x9gknd 4658 18 production production NN cord-010119-t1x9gknd 4658 19 of of IN cord-010119-t1x9gknd 4658 20 innovative innovative JJ cord-010119-t1x9gknd 4658 21 cellular cellular JJ cord-010119-t1x9gknd 4658 22 products product NNS cord-010119-t1x9gknd 4658 23 . . . cord-010119-t1x9gknd 4659 1 Although although IN cord-010119-t1x9gknd 4659 2 typically typically RB cord-010119-t1x9gknd 4659 3 associated associate VBN cord-010119-t1x9gknd 4659 4 with with IN cord-010119-t1x9gknd 4659 5 monoclonal monoclonal JJ cord-010119-t1x9gknd 4659 6 gammopathies gammopathy NNS cord-010119-t1x9gknd 4659 7 ( ( -LRB- cord-010119-t1x9gknd 4659 8 e.g. e.g. RB cord-010119-t1x9gknd 4659 9 Waldenstrom Waldenstrom NNP cord-010119-t1x9gknd 4659 10 's 's POS cord-010119-t1x9gknd 4659 11 macroglobulinemia macroglobulinemia NN cord-010119-t1x9gknd 4659 12 and and CC cord-010119-t1x9gknd 4659 13 multiple multiple JJ cord-010119-t1x9gknd 4659 14 myeloma myeloma NN cord-010119-t1x9gknd 4659 15 ) ) -RRB- cord-010119-t1x9gknd 4659 16 , , , cord-010119-t1x9gknd 4659 17 HVS HVS NNP cord-010119-t1x9gknd 4659 18 has have VBZ cord-010119-t1x9gknd 4659 19 rarely rarely RB cord-010119-t1x9gknd 4659 20 been be VBN cord-010119-t1x9gknd 4659 21 reported report VBN cord-010119-t1x9gknd 4659 22 in in IN cord-010119-t1x9gknd 4659 23 patients patient NNS cord-010119-t1x9gknd 4659 24 with with IN cord-010119-t1x9gknd 4659 25 disorders disorder NNS cord-010119-t1x9gknd 4659 26 of of IN cord-010119-t1x9gknd 4659 27 immune immune JJ cord-010119-t1x9gknd 4659 28 system system NN cord-010119-t1x9gknd 4659 29 such such JJ cord-010119-t1x9gknd 4659 30 as as IN cord-010119-t1x9gknd 4659 31 rheumatoid rheumatoid NN cord-010119-t1x9gknd 4659 32 disease disease NN cord-010119-t1x9gknd 4659 33 , , , cord-010119-t1x9gknd 4659 34 Sjogren Sjogren NNP cord-010119-t1x9gknd 4659 35 's 's POS cord-010119-t1x9gknd 4659 36 syndrome syndrome NN cord-010119-t1x9gknd 4659 37 , , , cord-010119-t1x9gknd 4659 38 HIV HIV NNP cord-010119-t1x9gknd 4659 39 and and CC cord-010119-t1x9gknd 4659 40 IgG4-related igg4-related JJ cord-010119-t1x9gknd 4659 41 diseases disease NNS cord-010119-t1x9gknd 4659 42 . . . cord-010119-t1x9gknd 4660 1 Therapeutic therapeutic JJ cord-010119-t1x9gknd 4660 2 plasma plasma NN cord-010119-t1x9gknd 4660 3 exchange exchange NN cord-010119-t1x9gknd 4660 4 ( ( -LRB- cord-010119-t1x9gknd 4660 5 TPE TPE NNP cord-010119-t1x9gknd 4660 6 ) ) -RRB- cord-010119-t1x9gknd 4660 7 is be VBZ cord-010119-t1x9gknd 4660 8 indicated indicate VBN cord-010119-t1x9gknd 4660 9 in in IN cord-010119-t1x9gknd 4660 10 HVS HVS NNP cord-010119-t1x9gknd 4660 11 due due JJ cord-010119-t1x9gknd 4660 12 to to IN cord-010119-t1x9gknd 4660 13 monoclonal monoclonal JJ cord-010119-t1x9gknd 4660 14 gammopathy gammopathy NN cord-010119-t1x9gknd 4660 15 ( ( -LRB- cord-010119-t1x9gknd 4660 16 ASFA ASFA NNP cord-010119-t1x9gknd 4660 17 category category NN cord-010119-t1x9gknd 4660 18 1 1 CD cord-010119-t1x9gknd 4660 19 indication indication NN cord-010119-t1x9gknd 4660 20 ) ) -RRB- cord-010119-t1x9gknd 4660 21 . . . cord-010119-t1x9gknd 4661 1 However however RB cord-010119-t1x9gknd 4661 2 , , , cord-010119-t1x9gknd 4661 3 there there EX cord-010119-t1x9gknd 4661 4 are be VBP cord-010119-t1x9gknd 4661 5 limited limited JJ cord-010119-t1x9gknd 4661 6 data datum NNS cord-010119-t1x9gknd 4661 7 for for IN cord-010119-t1x9gknd 4661 8 the the DT cord-010119-t1x9gknd 4661 9 utility utility NN cord-010119-t1x9gknd 4661 10 of of IN cord-010119-t1x9gknd 4661 11 TPE TPE NNP cord-010119-t1x9gknd 4661 12 in in IN cord-010119-t1x9gknd 4661 13 HVS HVS NNP cord-010119-t1x9gknd 4661 14 due due JJ cord-010119-t1x9gknd 4661 15 to to IN cord-010119-t1x9gknd 4661 16 polyclonal polyclonal JJ cord-010119-t1x9gknd 4661 17 gammopathy gammopathy NN cord-010119-t1x9gknd 4661 18 . . . cord-010119-t1x9gknd 4662 1 Study Study NNP cord-010119-t1x9gknd 4662 2 Design Design NNP cord-010119-t1x9gknd 4662 3 / / SYM cord-010119-t1x9gknd 4662 4 Methods method NNS cord-010119-t1x9gknd 4662 5 : : : cord-010119-t1x9gknd 4663 1 A a DT cord-010119-t1x9gknd 4663 2 70 70 CD cord-010119-t1x9gknd 4663 3 year year NN cord-010119-t1x9gknd 4663 4 old old JJ cord-010119-t1x9gknd 4663 5 female female JJ cord-010119-t1x9gknd 4663 6 patient patient NN cord-010119-t1x9gknd 4663 7 with with IN cord-010119-t1x9gknd 4663 8 a a DT cord-010119-t1x9gknd 4663 9 medical medical JJ cord-010119-t1x9gknd 4663 10 history history NN cord-010119-t1x9gknd 4663 11 significant significant JJ cord-010119-t1x9gknd 4663 12 for for IN cord-010119-t1x9gknd 4663 13 seropositive seropositive JJ cord-010119-t1x9gknd 4663 14 erosive erosive JJ cord-010119-t1x9gknd 4663 15 rheumatoid rheumatoid NN cord-010119-t1x9gknd 4663 16 arthritis arthritis NN cord-010119-t1x9gknd 4663 17 , , , cord-010119-t1x9gknd 4663 18 hypertension hypertension NN cord-010119-t1x9gknd 4663 19 , , , cord-010119-t1x9gknd 4663 20 diabetes diabetes NN cord-010119-t1x9gknd 4663 21 mellitus mellitus NN cord-010119-t1x9gknd 4663 22 , , , cord-010119-t1x9gknd 4663 23 cutaneous cutaneous JJ cord-010119-t1x9gknd 4663 24 lupus lupus NN cord-010119-t1x9gknd 4663 25 and and CC cord-010119-t1x9gknd 4663 26 diffuse diffuse VB cord-010119-t1x9gknd 4663 27 parenchymal parenchymal JJ cord-010119-t1x9gknd 4663 28 lung lung NN cord-010119-t1x9gknd 4663 29 disease disease NN cord-010119-t1x9gknd 4663 30 , , , cord-010119-t1x9gknd 4663 31 presented present VBN cord-010119-t1x9gknd 4663 32 to to IN cord-010119-t1x9gknd 4663 33 our -PRON- PRP$ cord-010119-t1x9gknd 4663 34 institution institution NN cord-010119-t1x9gknd 4663 35 with with IN cord-010119-t1x9gknd 4663 36 complaints complaint NNS cord-010119-t1x9gknd 4663 37 of of IN cord-010119-t1x9gknd 4663 38 progressive progressive JJ cord-010119-t1x9gknd 4663 39 fatigue fatigue NN cord-010119-t1x9gknd 4663 40 , , , cord-010119-t1x9gknd 4663 41 muscle muscle NN cord-010119-t1x9gknd 4663 42 weakness weakness NN cord-010119-t1x9gknd 4663 43 , , , cord-010119-t1x9gknd 4663 44 poor poor JJ cord-010119-t1x9gknd 4663 45 appetite appetite NN cord-010119-t1x9gknd 4663 46 , , , cord-010119-t1x9gknd 4663 47 headache headache NN cord-010119-t1x9gknd 4663 48 and and CC cord-010119-t1x9gknd 4663 49 epistaxis epistaxis NN cord-010119-t1x9gknd 4663 50 for for IN cord-010119-t1x9gknd 4663 51 a a DT cord-010119-t1x9gknd 4663 52 few few JJ cord-010119-t1x9gknd 4663 53 months month NNS cord-010119-t1x9gknd 4663 54 . . . cord-010119-t1x9gknd 4664 1 Fundoscopic fundoscopic JJ cord-010119-t1x9gknd 4664 2 examination examination NN cord-010119-t1x9gknd 4664 3 showed show VBD cord-010119-t1x9gknd 4664 4 dilated dilated JJ cord-010119-t1x9gknd 4664 5 and and CC cord-010119-t1x9gknd 4664 6 tortuous tortuous JJ cord-010119-t1x9gknd 4664 7 vasculature vasculature NN cord-010119-t1x9gknd 4664 8 as as RB cord-010119-t1x9gknd 4664 9 well well RB cord-010119-t1x9gknd 4664 10 as as IN cord-010119-t1x9gknd 4664 11 bilateral bilateral JJ cord-010119-t1x9gknd 4664 12 retinal retinal JJ cord-010119-t1x9gknd 4664 13 hemorrhages hemorrhage NNS cord-010119-t1x9gknd 4664 14 ( ( -LRB- cord-010119-t1x9gknd 4664 15 mixed mixed JJ cord-010119-t1x9gknd 4664 16 flame flame NN cord-010119-t1x9gknd 4664 17 - - HYPH cord-010119-t1x9gknd 4664 18 shaped shape VBN cord-010119-t1x9gknd 4664 19 and and CC cord-010119-t1x9gknd 4664 20 dot dot NN cord-010119-t1x9gknd 4664 21 - - HYPH cord-010119-t1x9gknd 4664 22 blot blot NN cord-010119-t1x9gknd 4664 23 patterns pattern NNS cord-010119-t1x9gknd 4664 24 ) ) -RRB- cord-010119-t1x9gknd 4664 25 . . . cord-010119-t1x9gknd 4665 1 Pertinent pertinent JJ cord-010119-t1x9gknd 4665 2 laboratory laboratory NN cord-010119-t1x9gknd 4665 3 findings finding NNS cord-010119-t1x9gknd 4665 4 included include VBD cord-010119-t1x9gknd 4665 5 a a DT cord-010119-t1x9gknd 4665 6 positive positive JJ cord-010119-t1x9gknd 4665 7 anti anti JJ cord-010119-t1x9gknd 4665 8 - - JJ cord-010119-t1x9gknd 4665 9 nuclear nuclear JJ cord-010119-t1x9gknd 4665 10 antibody antibody NN cord-010119-t1x9gknd 4665 11 screen screen NN cord-010119-t1x9gknd 4665 12 with with IN cord-010119-t1x9gknd 4665 13 anti anti JJ cord-010119-t1x9gknd 4665 14 - - JJ cord-010119-t1x9gknd 4665 15 histone histone JJ cord-010119-t1x9gknd 4665 16 antibodies antibody NNS cord-010119-t1x9gknd 4665 17 and and CC cord-010119-t1x9gknd 4665 18 anti anti JJ cord-010119-t1x9gknd 4665 19 - - JJ cord-010119-t1x9gknd 4665 20 Ro ro JJ cord-010119-t1x9gknd 4665 21 antibodies antibody NNS cord-010119-t1x9gknd 4665 22 . . . cord-010119-t1x9gknd 4666 1 Serum serum NN cord-010119-t1x9gknd 4666 2 rheumatoid rheumatoid NN cord-010119-t1x9gknd 4666 3 factor factor NN cord-010119-t1x9gknd 4666 4 was be VBD cord-010119-t1x9gknd 4666 5 markedly markedly RB cord-010119-t1x9gknd 4666 6 elevated elevate VBN cord-010119-t1x9gknd 4666 7 to to IN cord-010119-t1x9gknd 4666 8 57,000 57,000 CD cord-010119-t1x9gknd 4666 9 IU IU NNP cord-010119-t1x9gknd 4666 10 / / SYM cord-010119-t1x9gknd 4666 11 mls mls NNP cord-010119-t1x9gknd 4666 12 ( ( -LRB- cord-010119-t1x9gknd 4666 13 ref ref NN cord-010119-t1x9gknd 4666 14 . . . cord-010119-t1x9gknd 4667 1 range range VB cord-010119-t1x9gknd 4667 2 < < NNP cord-010119-t1x9gknd 4667 3 35 35 CD cord-010119-t1x9gknd 4667 4 ) ) -RRB- cord-010119-t1x9gknd 4667 5 and and CC cord-010119-t1x9gknd 4667 6 anti anti JJ cord-010119-t1x9gknd 4667 7 - - JJ cord-010119-t1x9gknd 4667 8 cyclic cyclic JJ cord-010119-t1x9gknd 4667 9 citrulline citrulline NN cord-010119-t1x9gknd 4667 10 peptide peptide NN cord-010119-t1x9gknd 4667 11 antibody antibody NN cord-010119-t1x9gknd 4667 12 was be VBD cord-010119-t1x9gknd 4667 13 elevated elevate VBN cord-010119-t1x9gknd 4667 14 to to IN cord-010119-t1x9gknd 4667 15 34,339 34,339 CD cord-010119-t1x9gknd 4667 16 units unit NNS cord-010119-t1x9gknd 4667 17 ( ( -LRB- cord-010119-t1x9gknd 4667 18 ref ref NN cord-010119-t1x9gknd 4667 19 . . . cord-010119-t1x9gknd 4668 1 range range VB cord-010119-t1x9gknd 4668 2 < < XX cord-010119-t1x9gknd 4668 3 20 20 CD cord-010119-t1x9gknd 4668 4 ) ) -RRB- cord-010119-t1x9gknd 4668 5 . . . cord-010119-t1x9gknd 4669 1 Serum serum NN cord-010119-t1x9gknd 4669 2 protein protein NN cord-010119-t1x9gknd 4669 3 electrophoresis electrophoresis NN cord-010119-t1x9gknd 4669 4 and and CC cord-010119-t1x9gknd 4669 5 immunofixation immunofixation NN cord-010119-t1x9gknd 4669 6 demonstrated demonstrate VBD cord-010119-t1x9gknd 4669 7 a a DT cord-010119-t1x9gknd 4669 8 polyclonal polyclonal JJ cord-010119-t1x9gknd 4669 9 hypergammaglobulinemia hypergammaglobulinemia NN cord-010119-t1x9gknd 4669 10 ; ; : cord-010119-t1x9gknd 4669 11 protein protein NN cord-010119-t1x9gknd 4669 12 precipitates precipitate NNS cord-010119-t1x9gknd 4669 13 were be VBD cord-010119-t1x9gknd 4669 14 noted note VBN cord-010119-t1x9gknd 4669 15 at at IN cord-010119-t1x9gknd 4669 16 the the DT cord-010119-t1x9gknd 4669 17 point point NN cord-010119-t1x9gknd 4669 18 of of IN cord-010119-t1x9gknd 4669 19 application application NN cord-010119-t1x9gknd 4669 20 , , , cord-010119-t1x9gknd 4669 21 suggestive suggestive JJ cord-010119-t1x9gknd 4669 22 of of IN cord-010119-t1x9gknd 4669 23 circulating circulate VBG cord-010119-t1x9gknd 4669 24 immune immune JJ cord-010119-t1x9gknd 4669 25 complexes complex NNS cord-010119-t1x9gknd 4669 26 . . . cord-010119-t1x9gknd 4670 1 Serum serum NN cord-010119-t1x9gknd 4670 2 IgG IgG NNP cord-010119-t1x9gknd 4670 3 , , , cord-010119-t1x9gknd 4670 4 IgM IgM NNP cord-010119-t1x9gknd 4670 5 and and CC cord-010119-t1x9gknd 4670 6 IgA IgA NNP cord-010119-t1x9gknd 4670 7 were be VBD cord-010119-t1x9gknd 4670 8 4610 4610 CD cord-010119-t1x9gknd 4670 9 , , , cord-010119-t1x9gknd 4670 10 2890 2890 CD cord-010119-t1x9gknd 4670 11 and and CC cord-010119-t1x9gknd 4670 12 1320 1320 CD cord-010119-t1x9gknd 4670 13 mg mg NNP cord-010119-t1x9gknd 4670 14 / / SYM cord-010119-t1x9gknd 4670 15 dL dL NNP cord-010119-t1x9gknd 4670 16 respectively respectively RB cord-010119-t1x9gknd 4670 17 . . . cord-010119-t1x9gknd 4671 1 A a DT cord-010119-t1x9gknd 4671 2 cryoglobulin cryoglobulin JJ cord-010119-t1x9gknd 4671 3 screen screen NN cord-010119-t1x9gknd 4671 4 was be VBD cord-010119-t1x9gknd 4671 5 negative negative JJ cord-010119-t1x9gknd 4671 6 . . . cord-010119-t1x9gknd 4672 1 Serum serum NN cord-010119-t1x9gknd 4672 2 free free JJ cord-010119-t1x9gknd 4672 3 kappa kappa NN cord-010119-t1x9gknd 4672 4 to to TO cord-010119-t1x9gknd 4672 5 lambda lambda NN cord-010119-t1x9gknd 4672 6 ratio ratio NN cord-010119-t1x9gknd 4672 7 was be VBD cord-010119-t1x9gknd 4672 8 1.74 1.74 CD cord-010119-t1x9gknd 4672 9 . . . cord-010119-t1x9gknd 4673 1 Peripheral peripheral JJ cord-010119-t1x9gknd 4673 2 blood blood NN cord-010119-t1x9gknd 4673 3 flow flow NN cord-010119-t1x9gknd 4673 4 cytometry cytometry NN cord-010119-t1x9gknd 4673 5 did do VBD cord-010119-t1x9gknd 4673 6 not not RB cord-010119-t1x9gknd 4673 7 identify identify VB cord-010119-t1x9gknd 4673 8 any any DT cord-010119-t1x9gknd 4673 9 monoclonal monoclonal JJ cord-010119-t1x9gknd 4673 10 Bcell Bcell NNP cord-010119-t1x9gknd 4673 11 population population NN cord-010119-t1x9gknd 4673 12 . . . cord-010119-t1x9gknd 4674 1 Plasma plasma NN cord-010119-t1x9gknd 4674 2 viscosity viscosity NN cord-010119-t1x9gknd 4674 3 was be VBD cord-010119-t1x9gknd 4674 4 noted note VBN cord-010119-t1x9gknd 4674 5 to to TO cord-010119-t1x9gknd 4674 6 be be VB cord-010119-t1x9gknd 4674 7 8.5 8.5 CD cord-010119-t1x9gknd 4674 8 centipoise centipoise NN cord-010119-t1x9gknd 4674 9 ( ( -LRB- cord-010119-t1x9gknd 4674 10 cp cp NNP cord-010119-t1x9gknd 4674 11 ) ) -RRB- cord-010119-t1x9gknd 4674 12 at at IN cord-010119-t1x9gknd 4674 13 admission admission NN cord-010119-t1x9gknd 4674 14 ( ( -LRB- cord-010119-t1x9gknd 4674 15 ref ref NN cord-010119-t1x9gknd 4674 16 . . . cord-010119-t1x9gknd 4675 1 range range VB cord-010119-t1x9gknd 4675 2 1.6 1.6 CD cord-010119-t1x9gknd 4675 3 -1.9 -1.9 CD cord-010119-t1x9gknd 4675 4 ) ) -RRB- cord-010119-t1x9gknd 4675 5 . . . cord-010119-t1x9gknd 4676 1 PET PET NNP cord-010119-t1x9gknd 4676 2 - - HYPH cord-010119-t1x9gknd 4676 3 CT CT NNP cord-010119-t1x9gknd 4676 4 imaging imaging NN cord-010119-t1x9gknd 4676 5 was be VBD cord-010119-t1x9gknd 4676 6 negative negative JJ cord-010119-t1x9gknd 4676 7 . . . cord-010119-t1x9gknd 4677 1 The the DT cord-010119-t1x9gknd 4677 2 patient patient NN cord-010119-t1x9gknd 4677 3 was be VBD cord-010119-t1x9gknd 4677 4 treated treat VBN cord-010119-t1x9gknd 4677 5 with with IN cord-010119-t1x9gknd 4677 6 high high JJ cord-010119-t1x9gknd 4677 7 dose dose NN cord-010119-t1x9gknd 4677 8 steroids steroid NNS cord-010119-t1x9gknd 4677 9 ; ; : cord-010119-t1x9gknd 4677 10 a a DT cord-010119-t1x9gknd 4677 11 single single JJ cord-010119-t1x9gknd 4677 12 TPE TPE NNP cord-010119-t1x9gknd 4677 13 procedure procedure NN cord-010119-t1x9gknd 4677 14 was be VBD cord-010119-t1x9gknd 4677 15 performed perform VBN cord-010119-t1x9gknd 4677 16 using use VBG cord-010119-t1x9gknd 4677 17 the the DT cord-010119-t1x9gknd 4677 18 following follow VBG cord-010119-t1x9gknd 4677 19 parameters parameter NNS cord-010119-t1x9gknd 4677 20 : : : cord-010119-t1x9gknd 4677 21 volume volume NN cord-010119-t1x9gknd 4677 22 treated treat VBN cord-010119-t1x9gknd 4677 23 -1 -1 CC cord-010119-t1x9gknd 4677 24 total total JJ cord-010119-t1x9gknd 4677 25 plasma plasma NN cord-010119-t1x9gknd 4677 26 volume volume NN cord-010119-t1x9gknd 4677 27 ; ; : cord-010119-t1x9gknd 4677 28 replacement replacement NN cord-010119-t1x9gknd 4677 29 fluid fluid NN cord-010119-t1x9gknd 4677 30 -5 -5 CD cord-010119-t1x9gknd 4677 31 % % NN cord-010119-t1x9gknd 4677 32 albumin albumin NN cord-010119-t1x9gknd 4677 33 and and CC cord-010119-t1x9gknd 4677 34 normal normal JJ cord-010119-t1x9gknd 4677 35 saline saline NN cord-010119-t1x9gknd 4677 36 in in IN cord-010119-t1x9gknd 4677 37 a a DT cord-010119-t1x9gknd 4677 38 50:50 50:50 CD cord-010119-t1x9gknd 4677 39 ratio ratio NN cord-010119-t1x9gknd 4677 40 ; ; : cord-010119-t1x9gknd 4677 41 replacement replacement NN cord-010119-t1x9gknd 4677 42 fluid fluid NN cord-010119-t1x9gknd 4677 43 volume volume NN cord-010119-t1x9gknd 4677 44 : : : cord-010119-t1x9gknd 4677 45 110 110 CD cord-010119-t1x9gknd 4677 46 % % NN cord-010119-t1x9gknd 4677 47 of of IN cord-010119-t1x9gknd 4677 48 the the DT cord-010119-t1x9gknd 4677 49 total total JJ cord-010119-t1x9gknd 4677 50 volume volume NN cord-010119-t1x9gknd 4677 51 processed process VBN cord-010119-t1x9gknd 4677 52 . . . cord-010119-t1x9gknd 4678 1 The the DT cord-010119-t1x9gknd 4678 2 procedure procedure NN cord-010119-t1x9gknd 4678 3 was be VBD cord-010119-t1x9gknd 4678 4 tolerated tolerate VBN cord-010119-t1x9gknd 4678 5 without without IN cord-010119-t1x9gknd 4678 6 complication complication NN cord-010119-t1x9gknd 4678 7 . . . cord-010119-t1x9gknd 4679 1 Results result NNS cord-010119-t1x9gknd 4679 2 / / SYM cord-010119-t1x9gknd 4679 3 Findings finding NNS cord-010119-t1x9gknd 4679 4 : : : cord-010119-t1x9gknd 4679 5 Immediately immediately RB cord-010119-t1x9gknd 4679 6 post post VB cord-010119-t1x9gknd 4679 7 - - JJ cord-010119-t1x9gknd 4679 8 TPE tpe NN cord-010119-t1x9gknd 4680 1 her -PRON- PRP$ cord-010119-t1x9gknd 4680 2 plasma plasma NN cord-010119-t1x9gknd 4680 3 viscosity viscosity NN cord-010119-t1x9gknd 4680 4 level level NN cord-010119-t1x9gknd 4680 5 dropped drop VBD cord-010119-t1x9gknd 4680 6 to to IN cord-010119-t1x9gknd 4680 7 2.4 2.4 CD cord-010119-t1x9gknd 4680 8 cp cp NN cord-010119-t1x9gknd 4680 9 . . . cord-010119-t1x9gknd 4681 1 Serum serum NN cord-010119-t1x9gknd 4681 2 IgG IgG NNP cord-010119-t1x9gknd 4681 3 , , , cord-010119-t1x9gknd 4681 4 IgM IgM NNP cord-010119-t1x9gknd 4681 5 and and CC cord-010119-t1x9gknd 4681 6 IgA IgA NNP cord-010119-t1x9gknd 4681 7 levels level NNS cord-010119-t1x9gknd 4681 8 decreased decrease VBD cord-010119-t1x9gknd 4681 9 to to IN cord-010119-t1x9gknd 4681 10 2040 2040 CD cord-010119-t1x9gknd 4681 11 , , , cord-010119-t1x9gknd 4681 12 1510 1510 CD cord-010119-t1x9gknd 4681 13 and and CC cord-010119-t1x9gknd 4681 14 672 672 CD cord-010119-t1x9gknd 4681 15 mg mg NNP cord-010119-t1x9gknd 4681 16 / / SYM cord-010119-t1x9gknd 4681 17 dL dl NN cord-010119-t1x9gknd 4681 18 respectively respectively RB cord-010119-t1x9gknd 4681 19 . . . cord-010119-t1x9gknd 4682 1 Her -PRON- PRP$ cord-010119-t1x9gknd 4682 2 RF rf NN cord-010119-t1x9gknd 4682 3 had have VBD cord-010119-t1x9gknd 4682 4 decreased decrease VBN cord-010119-t1x9gknd 4682 5 to to IN cord-010119-t1x9gknd 4682 6 19,900 19,900 CD cord-010119-t1x9gknd 4682 7 IU IU NNP cord-010119-t1x9gknd 4682 8 / / SYM cord-010119-t1x9gknd 4682 9 ml ml NN cord-010119-t1x9gknd 4682 10 . . . cord-010119-t1x9gknd 4683 1 The the DT cord-010119-t1x9gknd 4683 2 patient patient NN cord-010119-t1x9gknd 4683 3 reported report VBD cord-010119-t1x9gknd 4683 4 subjective subjective JJ cord-010119-t1x9gknd 4683 5 improvement improvement NN cord-010119-t1x9gknd 4683 6 in in IN cord-010119-t1x9gknd 4683 7 strength strength NN cord-010119-t1x9gknd 4683 8 . . . cord-010119-t1x9gknd 4684 1 She -PRON- PRP cord-010119-t1x9gknd 4684 2 subsequently subsequently RB cord-010119-t1x9gknd 4684 3 received receive VBD cord-010119-t1x9gknd 4684 4 two two CD cord-010119-t1x9gknd 4684 5 infusions infusion NNS cord-010119-t1x9gknd 4684 6 of of IN cord-010119-t1x9gknd 4684 7 rituximab rituximab NN cord-010119-t1x9gknd 4684 8 separated separate VBN cord-010119-t1x9gknd 4684 9 by by IN cord-010119-t1x9gknd 4684 10 two two CD cord-010119-t1x9gknd 4684 11 weeks week NNS cord-010119-t1x9gknd 4684 12 . . . cord-010119-t1x9gknd 4685 1 Her -PRON- PRP$ cord-010119-t1x9gknd 4685 2 plasma plasma NN cord-010119-t1x9gknd 4685 3 viscosity viscosity NN cord-010119-t1x9gknd 4685 4 has have VBZ cord-010119-t1x9gknd 4685 5 remained remain VBN cord-010119-t1x9gknd 4685 6 less less JJR cord-010119-t1x9gknd 4685 7 than than IN cord-010119-t1x9gknd 4685 8 3 3 CD cord-010119-t1x9gknd 4685 9 cp cp NN cord-010119-t1x9gknd 4685 10 since since IN cord-010119-t1x9gknd 4685 11 TPE TPE NNP cord-010119-t1x9gknd 4685 12 . . . cord-010119-t1x9gknd 4686 1 Conclusion conclusion NN cord-010119-t1x9gknd 4686 2 : : : cord-010119-t1x9gknd 4686 3 Polycolonal Polycolonal NNP cord-010119-t1x9gknd 4686 4 gammomathy gammomathy NNP cord-010119-t1x9gknd 4686 5 ( ( -LRB- cord-010119-t1x9gknd 4686 6 e.g. e.g. RB cord-010119-t1x9gknd 4686 7 secondary secondary JJ cord-010119-t1x9gknd 4686 8 to to IN cord-010119-t1x9gknd 4686 9 RA RA NNP cord-010119-t1x9gknd 4686 10 ) ) -RRB- cord-010119-t1x9gknd 4686 11 is be VBZ cord-010119-t1x9gknd 4686 12 a a DT cord-010119-t1x9gknd 4686 13 rare rare JJ cord-010119-t1x9gknd 4686 14 cause cause NN cord-010119-t1x9gknd 4686 15 of of IN cord-010119-t1x9gknd 4686 16 HVS HVS NNP cord-010119-t1x9gknd 4686 17 . . . cord-010119-t1x9gknd 4687 1 TPE TPE NNP cord-010119-t1x9gknd 4687 2 can can MD cord-010119-t1x9gknd 4687 3 provide provide VB cord-010119-t1x9gknd 4687 4 transient transient JJ cord-010119-t1x9gknd 4687 5 relief relief NN cord-010119-t1x9gknd 4687 6 of of IN cord-010119-t1x9gknd 4687 7 symptoms symptom NNS cord-010119-t1x9gknd 4687 8 in in IN cord-010119-t1x9gknd 4687 9 unusual unusual JJ cord-010119-t1x9gknd 4687 10 cases case NNS cord-010119-t1x9gknd 4687 11 of of IN cord-010119-t1x9gknd 4687 12 HVS HVS NNP cord-010119-t1x9gknd 4687 13 and and CC cord-010119-t1x9gknd 4687 14 may may MD cord-010119-t1x9gknd 4687 15 facilitate facilitate VB cord-010119-t1x9gknd 4687 16 therapy therapy NN cord-010119-t1x9gknd 4687 17 to to TO cord-010119-t1x9gknd 4687 18 prevent prevent VB cord-010119-t1x9gknd 4687 19 recurrent recurrent JJ cord-010119-t1x9gknd 4687 20 HVS HVS NNP cord-010119-t1x9gknd 4687 21 episodes episode NNS cord-010119-t1x9gknd 4687 22 . . . cord-010119-t1x9gknd 4688 1 Therapeutic Therapeutic NNP cord-010119-t1x9gknd 4688 2 Plasma Plasma NNP cord-010119-t1x9gknd 4688 3 Exchange Exchange NNP cord-010119-t1x9gknd 4688 4 in in IN cord-010119-t1x9gknd 4688 5 Neuromyelitis Neuromyelitis NNP cord-010119-t1x9gknd 4688 6 Optica Optica NNP cord-010119-t1x9gknd 4688 7 Spectrum Spectrum NNP cord-010119-t1x9gknd 4688 8 Disorders Disorders NNPS cord-010119-t1x9gknd 4688 9 -Experience -Experience NNP cord-010119-t1x9gknd 4688 10 from from IN cord-010119-t1x9gknd 4688 11 Tertiary Tertiary NNP cord-010119-t1x9gknd 4688 12 Care Care NNP cord-010119-t1x9gknd 4688 13 Centre Centre NNP cord-010119-t1x9gknd 4688 14 in in IN cord-010119-t1x9gknd 4688 15 North North NNP cord-010119-t1x9gknd 4688 16 India India NNP cord-010119-t1x9gknd 4688 17 Ratti Ratti NNP cord-010119-t1x9gknd 4688 18 Ram Ram NNP cord-010119-t1x9gknd 4688 19 Sharma Sharma NNP cord-010119-t1x9gknd 4689 1 * * NFP cord-010119-t1x9gknd 4689 2 , , , cord-010119-t1x9gknd 4689 3 Rekha Rekha NNP cord-010119-t1x9gknd 4689 4 Hans Hans NNP cord-010119-t1x9gknd 4689 5 , , , cord-010119-t1x9gknd 4689 6 Satya Satya NNP cord-010119-t1x9gknd 4689 7 Prakash Prakash NNP cord-010119-t1x9gknd 4689 8 , , , cord-010119-t1x9gknd 4689 9 Naveen Naveen NNP cord-010119-t1x9gknd 4689 10 Sankhyan Sankhyan NNP cord-010119-t1x9gknd 4689 11 and and CC cord-010119-t1x9gknd 4689 12 Neelam Neelam NNP cord-010119-t1x9gknd 4689 13 Marwaha Marwaha NNP cord-010119-t1x9gknd 4689 14 . . . cord-010119-t1x9gknd 4690 1 Postgraduate Postgraduate NNP cord-010119-t1x9gknd 4690 2 Institute Institute NNP cord-010119-t1x9gknd 4690 3 of of IN cord-010119-t1x9gknd 4690 4 Medical Medical NNP cord-010119-t1x9gknd 4690 5 education education NN cord-010119-t1x9gknd 4690 6 and and CC cord-010119-t1x9gknd 4690 7 research research NN cord-010119-t1x9gknd 4691 1 Background Background NNP cord-010119-t1x9gknd 4691 2 / / SYM cord-010119-t1x9gknd 4691 3 Case Case NNP cord-010119-t1x9gknd 4691 4 Studies Studies NNPS cord-010119-t1x9gknd 4691 5 : : : cord-010119-t1x9gknd 4691 6 Neuromyelitis Neuromyelitis NNP cord-010119-t1x9gknd 4691 7 optica optica NN cord-010119-t1x9gknd 4691 8 spectrum spectrum NN cord-010119-t1x9gknd 4691 9 disorder disorder NN cord-010119-t1x9gknd 4691 10 ( ( -LRB- cord-010119-t1x9gknd 4691 11 NMOSD NMOSD NNP cord-010119-t1x9gknd 4691 12 ) ) -RRB- cord-010119-t1x9gknd 4691 13 is be VBZ cord-010119-t1x9gknd 4691 14 an an DT cord-010119-t1x9gknd 4691 15 idiopathic idiopathic JJ cord-010119-t1x9gknd 4691 16 inflammatory inflammatory JJ cord-010119-t1x9gknd 4691 17 demyelinating demyelinating JJ cord-010119-t1x9gknd 4691 18 disorder disorder NN cord-010119-t1x9gknd 4691 19 of of IN cord-010119-t1x9gknd 4691 20 central central JJ cord-010119-t1x9gknd 4691 21 nervous nervous JJ cord-010119-t1x9gknd 4691 22 system system NN cord-010119-t1x9gknd 4691 23 preferentially preferentially RB cord-010119-t1x9gknd 4691 24 involving involve VBG cord-010119-t1x9gknd 4691 25 optic optic JJ cord-010119-t1x9gknd 4691 26 nerve nerve NN cord-010119-t1x9gknd 4691 27 and and CC cord-010119-t1x9gknd 4691 28 upper upper JJ cord-010119-t1x9gknd 4691 29 segments segment NNS cord-010119-t1x9gknd 4691 30 of of IN cord-010119-t1x9gknd 4691 31 the the DT cord-010119-t1x9gknd 4691 32 spinal spinal JJ cord-010119-t1x9gknd 4691 33 cord cord NN cord-010119-t1x9gknd 4691 34 leading lead VBG cord-010119-t1x9gknd 4691 35 to to IN cord-010119-t1x9gknd 4691 36 optic optic JJ cord-010119-t1x9gknd 4691 37 neuritis neuritis NN cord-010119-t1x9gknd 4691 38 and and CC cord-010119-t1x9gknd 4691 39 myelitis myelitis NNP cord-010119-t1x9gknd 4691 40 . . . cord-010119-t1x9gknd 4692 1 TPE TPE NNP cord-010119-t1x9gknd 4692 2 is be VBZ cord-010119-t1x9gknd 4692 3 indicated indicate VBN cord-010119-t1x9gknd 4692 4 in in IN cord-010119-t1x9gknd 4692 5 acute acute JJ cord-010119-t1x9gknd 4692 6 phase phase NN cord-010119-t1x9gknd 4692 7 or or CC cord-010119-t1x9gknd 4692 8 as as IN cord-010119-t1x9gknd 4692 9 a a DT cord-010119-t1x9gknd 4692 10 maintenance maintenance NN cord-010119-t1x9gknd 4692 11 therapy therapy NN cord-010119-t1x9gknd 4692 12 to to TO cord-010119-t1x9gknd 4692 13 treat treat VB cord-010119-t1x9gknd 4692 14 or or CC cord-010119-t1x9gknd 4692 15 prevent prevent VB cord-010119-t1x9gknd 4692 16 relapses relapse NNS cord-010119-t1x9gknd 4692 17 in in IN cord-010119-t1x9gknd 4692 18 chronic chronic JJ cord-010119-t1x9gknd 4692 19 phase phase NN cord-010119-t1x9gknd 4692 20 . . . cord-010119-t1x9gknd 4693 1 Study Study NNP cord-010119-t1x9gknd 4693 2 Design Design NNP cord-010119-t1x9gknd 4693 3 / / SYM cord-010119-t1x9gknd 4693 4 Method method NN cord-010119-t1x9gknd 4693 5 : : : cord-010119-t1x9gknd 4694 1 To to TO cord-010119-t1x9gknd 4694 2 assess assess VB cord-010119-t1x9gknd 4694 3 the the DT cord-010119-t1x9gknd 4694 4 efficacy efficacy NN cord-010119-t1x9gknd 4694 5 of of IN cord-010119-t1x9gknd 4694 6 plasma plasma NN cord-010119-t1x9gknd 4694 7 exchange exchange NN cord-010119-t1x9gknd 4694 8 in in IN cord-010119-t1x9gknd 4694 9 patients patient NNS cord-010119-t1x9gknd 4694 10 of of IN cord-010119-t1x9gknd 4694 11 NMOSD NMOSD NNP cord-010119-t1x9gknd 4694 12 not not RB cord-010119-t1x9gknd 4694 13 responding respond VBG cord-010119-t1x9gknd 4694 14 to to IN cord-010119-t1x9gknd 4694 15 high high JJ cord-010119-t1x9gknd 4694 16 dose dose NN cord-010119-t1x9gknd 4694 17 intravenous intravenous JJ cord-010119-t1x9gknd 4694 18 steroids steroid NNS cord-010119-t1x9gknd 4694 19 . . . cord-010119-t1x9gknd 4695 1 we -PRON- PRP cord-010119-t1x9gknd 4695 2 did do VBD cord-010119-t1x9gknd 4695 3 a a DT cord-010119-t1x9gknd 4695 4 retrospective retrospective JJ cord-010119-t1x9gknd 4695 5 review review NN cord-010119-t1x9gknd 4695 6 of of IN cord-010119-t1x9gknd 4695 7 TPE TPE NNP cord-010119-t1x9gknd 4695 8 records record NNS cord-010119-t1x9gknd 4695 9 for for IN cord-010119-t1x9gknd 4695 10 patients patient NNS cord-010119-t1x9gknd 4695 11 with with IN cord-010119-t1x9gknd 4695 12 NMOSD NMOSD NNP cord-010119-t1x9gknd 4695 13 over over IN cord-010119-t1x9gknd 4695 14 a a DT cord-010119-t1x9gknd 4695 15 period period NN cord-010119-t1x9gknd 4695 16 of of IN cord-010119-t1x9gknd 4695 17 three three CD cord-010119-t1x9gknd 4695 18 years year NNS cord-010119-t1x9gknd 4695 19 ( ( -LRB- cord-010119-t1x9gknd 4695 20 Jan Jan NNP cord-010119-t1x9gknd 4695 21 2013 2013 CD cord-010119-t1x9gknd 4695 22 -Dec -Dec NNP cord-010119-t1x9gknd 4695 23 2016 2016 CD cord-010119-t1x9gknd 4695 24 ) ) -RRB- cord-010119-t1x9gknd 4695 25 . . . cord-010119-t1x9gknd 4696 1 TPE TPE NNP cord-010119-t1x9gknd 4696 2 was be VBD cord-010119-t1x9gknd 4696 3 done do VBN cord-010119-t1x9gknd 4696 4 using use VBG cord-010119-t1x9gknd 4696 5 , , , cord-010119-t1x9gknd 4696 6 Cobe Cobe NNP cord-010119-t1x9gknd 4696 7 spectra spectrum NNS cord-010119-t1x9gknd 4696 8 ( ( -LRB- cord-010119-t1x9gknd 4696 9 Terumo Terumo NNP cord-010119-t1x9gknd 4696 10 BCT BCT NNP cord-010119-t1x9gknd 4696 11 , , , cord-010119-t1x9gknd 4696 12 Lakewood Lakewood NNP cord-010119-t1x9gknd 4696 13 Co. Co. NNP cord-010119-t1x9gknd 4696 14 USA USA NNP cord-010119-t1x9gknd 4696 15 ) ) -RRB- cord-010119-t1x9gknd 4696 16 , , , cord-010119-t1x9gknd 4696 17 replacing replace VBG cord-010119-t1x9gknd 4696 18 one one CD cord-010119-t1x9gknd 4696 19 to to IN cord-010119-t1x9gknd 4696 20 one one CD cord-010119-t1x9gknd 4696 21 and and CC cord-010119-t1x9gknd 4696 22 half half JJ cord-010119-t1x9gknd 4696 23 patient patient NN cord-010119-t1x9gknd 4696 24 plasma plasma NN cord-010119-t1x9gknd 4696 25 volume volume NN cord-010119-t1x9gknd 4696 26 with with IN cord-010119-t1x9gknd 4696 27 5 5 CD cord-010119-t1x9gknd 4696 28 % % NN cord-010119-t1x9gknd 4696 29 human human JJ cord-010119-t1x9gknd 4696 30 serum serum NN cord-010119-t1x9gknd 4696 31 albumin albumin NN cord-010119-t1x9gknd 4696 32 or or CC cord-010119-t1x9gknd 4696 33 Fresh fresh JJ cord-010119-t1x9gknd 4696 34 frozen frozen JJ cord-010119-t1x9gknd 4696 35 plasma plasma NN cord-010119-t1x9gknd 4696 36 on on IN cord-010119-t1x9gknd 4696 37 alternate alternate JJ cord-010119-t1x9gknd 4696 38 days day NNS cord-010119-t1x9gknd 4696 39 . . . cord-010119-t1x9gknd 4697 1 The the DT cord-010119-t1x9gknd 4697 2 improvement improvement NN cord-010119-t1x9gknd 4697 3 in in IN cord-010119-t1x9gknd 4697 4 clinical clinical JJ cord-010119-t1x9gknd 4697 5 signs sign NNS cord-010119-t1x9gknd 4697 6 and and CC cord-010119-t1x9gknd 4697 7 symptoms symptom NNS cord-010119-t1x9gknd 4697 8 was be VBD cord-010119-t1x9gknd 4697 9 recorded record VBN cord-010119-t1x9gknd 4697 10 after after IN cord-010119-t1x9gknd 4697 11 each each DT cord-010119-t1x9gknd 4697 12 TPE TPE NNP cord-010119-t1x9gknd 4697 13 procedure procedure NN cord-010119-t1x9gknd 4697 14 and and CC cord-010119-t1x9gknd 4697 15 at at IN cord-010119-t1x9gknd 4697 16 the the DT cord-010119-t1x9gknd 4697 17 end end NN cord-010119-t1x9gknd 4697 18 of of IN cord-010119-t1x9gknd 4697 19 the the DT cord-010119-t1x9gknd 4697 20 therapy therapy NN cord-010119-t1x9gknd 4697 21 . . . cord-010119-t1x9gknd 4698 1 Adverse adverse JJ cord-010119-t1x9gknd 4698 2 reactions reaction NNS cord-010119-t1x9gknd 4698 3 if if IN cord-010119-t1x9gknd 4698 4 any any DT cord-010119-t1x9gknd 4698 5 were be VBD cord-010119-t1x9gknd 4698 6 also also RB cord-010119-t1x9gknd 4698 7 recorded record VBN cord-010119-t1x9gknd 4698 8 Results result NNS cord-010119-t1x9gknd 4699 1 /Finding /finde VBG cord-010119-t1x9gknd 4699 2 : : : cord-010119-t1x9gknd 4700 1 Eleven eleven CD cord-010119-t1x9gknd 4700 2 patients patient NNS cord-010119-t1x9gknd 4700 3 of of IN cord-010119-t1x9gknd 4700 4 NMOSD NMOSD NNP cord-010119-t1x9gknd 4700 5 between between IN cord-010119-t1x9gknd 4700 6 4 4 CD cord-010119-t1x9gknd 4700 7 to to TO cord-010119-t1x9gknd 4700 8 35 35 CD cord-010119-t1x9gknd 4700 9 years year NNS cord-010119-t1x9gknd 4700 10 age age NN cord-010119-t1x9gknd 4701 1 ( ( -LRB- cord-010119-t1x9gknd 4701 2 M m NN cord-010119-t1x9gknd 4701 3 : : : cord-010119-t1x9gknd 4701 4 F f NN cord-010119-t1x9gknd 4701 5 ; ; : cord-010119-t1x9gknd 4701 6 1:2 1:2 CD cord-010119-t1x9gknd 4701 7 ) ) -RRB- cord-010119-t1x9gknd 4701 8 underwent undergo VBD cord-010119-t1x9gknd 4701 9 62 62 CD cord-010119-t1x9gknd 4701 10 TPE TPE NNP cord-010119-t1x9gknd 4701 11 procedures procedure NNS cord-010119-t1x9gknd 4701 12 with with IN cord-010119-t1x9gknd 4701 13 an an DT cord-010119-t1x9gknd 4701 14 average average NN cord-010119-t1x9gknd 4701 15 of of IN cord-010119-t1x9gknd 4701 16 5.6 5.6 CD cord-010119-t1x9gknd 4701 17 per per IN cord-010119-t1x9gknd 4701 18 patient patient NN cord-010119-t1x9gknd 4701 19 . . . cord-010119-t1x9gknd 4702 1 All all PDT cord-010119-t1x9gknd 4702 2 the the DT cord-010119-t1x9gknd 4702 3 patients patient NNS cord-010119-t1x9gknd 4702 4 were be VBD cord-010119-t1x9gknd 4702 5 on on IN cord-010119-t1x9gknd 4702 6 high high JJ cord-010119-t1x9gknd 4702 7 dose dose NN cord-010119-t1x9gknd 4702 8 immunosuppressant immunosuppressant JJ cord-010119-t1x9gknd 4702 9 therapy therapy NN cord-010119-t1x9gknd 4702 10 without without IN cord-010119-t1x9gknd 4702 11 much much JJ cord-010119-t1x9gknd 4702 12 clinical clinical JJ cord-010119-t1x9gknd 4702 13 improvement improvement NN cord-010119-t1x9gknd 4702 14 . . . cord-010119-t1x9gknd 4703 1 Three three CD cord-010119-t1x9gknd 4703 2 ( ( -LRB- cord-010119-t1x9gknd 4703 3 27 27 CD cord-010119-t1x9gknd 4703 4 % % NN cord-010119-t1x9gknd 4703 5 ) ) -RRB- cord-010119-t1x9gknd 4704 1 patients patient NNS cord-010119-t1x9gknd 4704 2 had have VBD cord-010119-t1x9gknd 4704 3 only only RB cord-010119-t1x9gknd 4704 4 visual visual JJ cord-010119-t1x9gknd 4704 5 symptoms symptom NNS cord-010119-t1x9gknd 4704 6 , , , cord-010119-t1x9gknd 4704 7 5 5 CD cord-010119-t1x9gknd 4704 8 ( ( -LRB- cord-010119-t1x9gknd 4704 9 46 46 CD cord-010119-t1x9gknd 4704 10 % % NN cord-010119-t1x9gknd 4704 11 ) ) -RRB- cord-010119-t1x9gknd 4704 12 had have VBD cord-010119-t1x9gknd 4704 13 both both DT cord-010119-t1x9gknd 4704 14 visual visual JJ cord-010119-t1x9gknd 4704 15 as as RB cord-010119-t1x9gknd 4704 16 well well RB cord-010119-t1x9gknd 4704 17 as as IN cord-010119-t1x9gknd 4704 18 muscular muscular JJ cord-010119-t1x9gknd 4704 19 symptoms symptom NNS cord-010119-t1x9gknd 4704 20 whereas whereas IN cord-010119-t1x9gknd 4704 21 3 3 CD cord-010119-t1x9gknd 4704 22 ( ( -LRB- cord-010119-t1x9gknd 4704 23 27 27 CD cord-010119-t1x9gknd 4704 24 % % NN cord-010119-t1x9gknd 4704 25 ) ) -RRB- cord-010119-t1x9gknd 4704 26 patients patient NNS cord-010119-t1x9gknd 4704 27 had have VBD cord-010119-t1x9gknd 4704 28 muscular muscular JJ cord-010119-t1x9gknd 4704 29 symptoms symptom NNS cord-010119-t1x9gknd 4704 30 only only RB cord-010119-t1x9gknd 4704 31 . . . cord-010119-t1x9gknd 4705 1 Three three CD cord-010119-t1x9gknd 4705 2 ( ( -LRB- cord-010119-t1x9gknd 4705 3 27 27 CD cord-010119-t1x9gknd 4705 4 % % NN cord-010119-t1x9gknd 4705 5 ) ) -RRB- cord-010119-t1x9gknd 4705 6 out out IN cord-010119-t1x9gknd 4705 7 of of IN cord-010119-t1x9gknd 4705 8 the the DT cord-010119-t1x9gknd 4705 9 seven seven CD cord-010119-t1x9gknd 4705 10 tested test VBN cord-010119-t1x9gknd 4705 11 , , , cord-010119-t1x9gknd 4705 12 were be VBD cord-010119-t1x9gknd 4705 13 positive positive JJ cord-010119-t1x9gknd 4705 14 for for IN cord-010119-t1x9gknd 4705 15 AQP4-IgG. AQP4-IgG. NNP cord-010119-t1x9gknd 4706 1 All all PDT cord-010119-t1x9gknd 4706 2 the the DT cord-010119-t1x9gknd 4706 3 patients patient NNS cord-010119-t1x9gknd 4706 4 showed show VBD cord-010119-t1x9gknd 4706 5 significant significant JJ cord-010119-t1x9gknd 4706 6 improvement improvement NN cord-010119-t1x9gknd 4706 7 in in IN cord-010119-t1x9gknd 4706 8 their -PRON- PRP$ cord-010119-t1x9gknd 4706 9 visual visual JJ cord-010119-t1x9gknd 4706 10 symptoms symptom NNS cord-010119-t1x9gknd 4706 11 post post VBP cord-010119-t1x9gknd 4706 12 exchange exchange NN cord-010119-t1x9gknd 4706 13 , , , cord-010119-t1x9gknd 4706 14 from from IN cord-010119-t1x9gknd 4706 15 no no DT cord-010119-t1x9gknd 4706 16 vision vision NN cord-010119-t1x9gknd 4706 17 / / SYM cord-010119-t1x9gknd 4706 18 light light NN cord-010119-t1x9gknd 4706 19 perception perception NN cord-010119-t1x9gknd 4706 20 to to IN cord-010119-t1x9gknd 4706 21 finger finger NN cord-010119-t1x9gknd 4706 22 counting counting NN cord-010119-t1x9gknd 4706 23 in in IN cord-010119-t1x9gknd 4706 24 two two CD cord-010119-t1x9gknd 4706 25 patients patient NNS cord-010119-t1x9gknd 4706 26 , , , cord-010119-t1x9gknd 4706 27 recovery recovery NN cord-010119-t1x9gknd 4706 28 of of IN cord-010119-t1x9gknd 4706 29 colour colour NN cord-010119-t1x9gknd 4706 30 vision vision NN cord-010119-t1x9gknd 4706 31 and and CC cord-010119-t1x9gknd 4706 32 diplopia diplopia NN cord-010119-t1x9gknd 4706 33 in in IN cord-010119-t1x9gknd 4706 34 six six CD cord-010119-t1x9gknd 4706 35 patients patient NNS cord-010119-t1x9gknd 4706 36 . . . cord-010119-t1x9gknd 4707 1 Post post JJ cord-010119-t1x9gknd 4707 2 exchange exchange NN cord-010119-t1x9gknd 4707 3 recovery recovery NN cord-010119-t1x9gknd 4707 4 in in IN cord-010119-t1x9gknd 4707 5 the the DT cord-010119-t1x9gknd 4707 6 muscle muscle NN cord-010119-t1x9gknd 4707 7 power power NN cord-010119-t1x9gknd 4707 8 was be VBD cord-010119-t1x9gknd 4707 9 observed observe VBN cord-010119-t1x9gknd 4707 10 in in IN cord-010119-t1x9gknd 4707 11 8 8 CD cord-010119-t1x9gknd 4707 12 patients patient NNS cord-010119-t1x9gknd 4707 13 with with IN cord-010119-t1x9gknd 4707 14 grade-1 grade-1 NNP cord-010119-t1x9gknd 4707 15 , , , cord-010119-t1x9gknd 4707 16 in in IN cord-010119-t1x9gknd 4707 17 1 1 CD cord-010119-t1x9gknd 4707 18 patient patient NN cord-010119-t1x9gknd 4707 19 , , , cord-010119-t1x9gknd 4707 20 and and CC cord-010119-t1x9gknd 4707 21 by by IN cord-010119-t1x9gknd 4707 22 grade-2 grade-2 NNP cord-010119-t1x9gknd 4707 23 , , , cord-010119-t1x9gknd 4707 24 in in IN cord-010119-t1x9gknd 4707 25 seven seven CD cord-010119-t1x9gknd 4707 26 . . . cord-010119-t1x9gknd 4708 1 Adverse adverse JJ cord-010119-t1x9gknd 4708 2 events event NNS cord-010119-t1x9gknd 4708 3 were be VBD cord-010119-t1x9gknd 4708 4 observed observe VBN cord-010119-t1x9gknd 4708 5 in in IN cord-010119-t1x9gknd 4708 6 8 8 CD cord-010119-t1x9gknd 4708 7 % % NN cord-010119-t1x9gknd 4708 8 ( ( -LRB- cord-010119-t1x9gknd 4708 9 5/62 5/62 CD cord-010119-t1x9gknd 4708 10 ) ) -RRB- cord-010119-t1x9gknd 4708 11 of of IN cord-010119-t1x9gknd 4708 12 the the DT cord-010119-t1x9gknd 4708 13 procedures procedure NNS cord-010119-t1x9gknd 4708 14 with with IN cord-010119-t1x9gknd 4708 15 allergic allergic JJ cord-010119-t1x9gknd 4708 16 reactions reaction NNS cord-010119-t1x9gknd 4708 17 to to IN cord-010119-t1x9gknd 4708 18 replacement replacement NN cord-010119-t1x9gknd 4708 19 fluid fluid NN cord-010119-t1x9gknd 4708 20 as as IN cord-010119-t1x9gknd 4708 21 most most JJS cord-010119-t1x9gknd 4708 22 common common JJ cord-010119-t1x9gknd 4708 23 event event NN cord-010119-t1x9gknd 4708 24 ( ( -LRB- cord-010119-t1x9gknd 4708 25 n-3 n-3 NNP cord-010119-t1x9gknd 4708 26 ) ) -RRB- cord-010119-t1x9gknd 4708 27 followed follow VBN cord-010119-t1x9gknd 4708 28 by by IN cord-010119-t1x9gknd 4708 29 hypotension hypotension NN cord-010119-t1x9gknd 4708 30 ( ( -LRB- cord-010119-t1x9gknd 4708 31 n-2 n-2 NNP cord-010119-t1x9gknd 4708 32 ) ) -RRB- cord-010119-t1x9gknd 4708 33 . . . cord-010119-t1x9gknd 4709 1 Follow follow VB cord-010119-t1x9gknd 4709 2 up up RP cord-010119-t1x9gknd 4709 3 was be VBD cord-010119-t1x9gknd 4709 4 available available JJ cord-010119-t1x9gknd 4709 5 in in IN cord-010119-t1x9gknd 4709 6 55 55 CD cord-010119-t1x9gknd 4709 7 % % NN cord-010119-t1x9gknd 4709 8 ( ( -LRB- cord-010119-t1x9gknd 4709 9 6/11 6/11 CD cord-010119-t1x9gknd 4709 10 ) ) -RRB- cord-010119-t1x9gknd 4709 11 of of IN cord-010119-t1x9gknd 4709 12 patients patient NNS cord-010119-t1x9gknd 4709 13 and and CC cord-010119-t1x9gknd 4709 14 are be VBP cord-010119-t1x9gknd 4709 15 doing do VBG cord-010119-t1x9gknd 4709 16 well well RB cord-010119-t1x9gknd 4709 17 on on IN cord-010119-t1x9gknd 4709 18 immunosuppressive immunosuppressive JJ cord-010119-t1x9gknd 4709 19 therapy therapy NN cord-010119-t1x9gknd 4709 20 . . . cord-010119-t1x9gknd 4710 1 One one CD cord-010119-t1x9gknd 4710 2 patient patient NN cord-010119-t1x9gknd 4710 3 died die VBD cord-010119-t1x9gknd 4710 4 due due IN cord-010119-t1x9gknd 4710 5 to to IN cord-010119-t1x9gknd 4710 6 respiratory respiratory JJ cord-010119-t1x9gknd 4710 7 failure failure NN cord-010119-t1x9gknd 4710 8 after after IN cord-010119-t1x9gknd 4710 9 3 3 CD cord-010119-t1x9gknd 4710 10 months month NNS cord-010119-t1x9gknd 4710 11 and and CC cord-010119-t1x9gknd 4710 12 another another DT cord-010119-t1x9gknd 4710 13 had have VBD cord-010119-t1x9gknd 4710 14 relapse relapse NN cord-010119-t1x9gknd 4710 15 for for IN cord-010119-t1x9gknd 4710 16 which which WDT cord-010119-t1x9gknd 4710 17 he -PRON- PRP cord-010119-t1x9gknd 4710 18 underwent undergo VBD cord-010119-t1x9gknd 4710 19 second second JJ cord-010119-t1x9gknd 4710 20 TPE TPE NNP cord-010119-t1x9gknd 4710 21 cycle cycle NN cord-010119-t1x9gknd 4710 22 and and CC cord-010119-t1x9gknd 4710 23 continue continue VBP cord-010119-t1x9gknd 4710 24 to to TO cord-010119-t1x9gknd 4710 25 do do VB cord-010119-t1x9gknd 4710 26 well well RB cord-010119-t1x9gknd 4710 27 . . . cord-010119-t1x9gknd 4711 1 Conclusion conclusion NN cord-010119-t1x9gknd 4711 2 : : : cord-010119-t1x9gknd 4711 3 TPE TPE NNP cord-010119-t1x9gknd 4711 4 is be VBZ cord-010119-t1x9gknd 4711 5 a a DT cord-010119-t1x9gknd 4711 6 safe safe JJ cord-010119-t1x9gknd 4711 7 and and CC cord-010119-t1x9gknd 4711 8 effective effective JJ cord-010119-t1x9gknd 4711 9 adjunct adjunct NN cord-010119-t1x9gknd 4711 10 therapy therapy NN cord-010119-t1x9gknd 4711 11 to to IN cord-010119-t1x9gknd 4711 12 high high JJ cord-010119-t1x9gknd 4711 13 dose dose NN cord-010119-t1x9gknd 4711 14 immunosuppression immunosuppression NN cord-010119-t1x9gknd 4711 15 in in IN cord-010119-t1x9gknd 4711 16 NMOSD NMOSD NNP cord-010119-t1x9gknd 4711 17 . . . cord-010119-t1x9gknd 4712 1 Trima Trima NNP cord-010119-t1x9gknd 4712 2 Accel Accel NNP cord-010119-t1x9gknd 4712 3 Software Software NNP cord-010119-t1x9gknd 4712 4 Upgrade Upgrade NNP cord-010119-t1x9gknd 4712 5 from from IN cord-010119-t1x9gknd 4712 6 6.0 6.0 CD cord-010119-t1x9gknd 4712 7 to to IN cord-010119-t1x9gknd 4712 8 6.4 6.4 CD cord-010119-t1x9gknd 4712 9 for for IN cord-010119-t1x9gknd 4712 10 Platelet platelet NN cord-010119-t1x9gknd 4712 11 Collections collection NNS cord-010119-t1x9gknd 4712 12 Rachel Rachel NNP cord-010119-t1x9gknd 4712 13 M M NNP cord-010119-t1x9gknd 4712 14 Beck Beck NNP cord-010119-t1x9gknd 4713 1 * * NFP cord-010119-t1x9gknd 4713 2 , , , cord-010119-t1x9gknd 4713 3 Kimberly Kimberly NNP cord-010119-t1x9gknd 4713 4 J J NNP cord-010119-t1x9gknd 4713 5 Duffy Duffy NNP cord-010119-t1x9gknd 4713 6 , , , cord-010119-t1x9gknd 4713 7 Sandra Sandra NNP cord-010119-t1x9gknd 4713 8 Bryant Bryant NNP cord-010119-t1x9gknd 4713 9 , , , cord-010119-t1x9gknd 4713 10 Audrey Audrey NNP cord-010119-t1x9gknd 4713 11 E E NNP cord-010119-t1x9gknd 4713 12 Traun Traun NNP cord-010119-t1x9gknd 4713 13 , , , cord-010119-t1x9gknd 4713 14 Mary Mary NNP cord-010119-t1x9gknd 4713 15 M M NNP cord-010119-t1x9gknd 4713 16 Benike Benike NNP cord-010119-t1x9gknd 4713 17 , , , cord-010119-t1x9gknd 4713 18 James James NNP cord-010119-t1x9gknd 4713 19 R R NNP cord-010119-t1x9gknd 4713 20 Stubbs Stubbs NNP cord-010119-t1x9gknd 4713 21 and and CC cord-010119-t1x9gknd 4713 22 Justin Justin NNP cord-010119-t1x9gknd 4713 23 D D NNP cord-010119-t1x9gknd 4713 24 Kreuter Kreuter NNP cord-010119-t1x9gknd 4713 25 . . . cord-010119-t1x9gknd 4714 1 Mayo Mayo NNP cord-010119-t1x9gknd 4714 2 Clinic Clinic NNP cord-010119-t1x9gknd 4714 3 Background Background NNP cord-010119-t1x9gknd 4714 4 / / SYM cord-010119-t1x9gknd 4714 5 Case Case NNP cord-010119-t1x9gknd 4714 6 Studies Studies NNPS cord-010119-t1x9gknd 4714 7 : : : cord-010119-t1x9gknd 4715 1 TerumoBCT TerumoBCT NNP cord-010119-t1x9gknd 4715 2 released release VBD cord-010119-t1x9gknd 4715 3 Trima Trima NNP cord-010119-t1x9gknd 4715 4 Accel Accel NNP cord-010119-t1x9gknd 4715 5 software software NN cord-010119-t1x9gknd 4715 6 version version NN cord-010119-t1x9gknd 4715 7 6.4 6.4 CD cord-010119-t1x9gknd 4715 8 as as IN cord-010119-t1x9gknd 4715 9 an an DT cord-010119-t1x9gknd 4715 10 enhancement enhancement NN cord-010119-t1x9gknd 4715 11 to to TO cord-010119-t1x9gknd 4715 12 allow allow VB cord-010119-t1x9gknd 4715 13 for for IN cord-010119-t1x9gknd 4715 14 the the DT cord-010119-t1x9gknd 4715 15 collection collection NN cord-010119-t1x9gknd 4715 16 of of IN cord-010119-t1x9gknd 4715 17 platelets platelet NNS cord-010119-t1x9gknd 4715 18 ( ( -LRB- cord-010119-t1x9gknd 4715 19 plt plt NNP cord-010119-t1x9gknd 4715 20 ) ) -RRB- cord-010119-t1x9gknd 4715 21 with with IN cord-010119-t1x9gknd 4715 22 Platelet Platelet NNP cord-010119-t1x9gknd 4715 23 Additive Additive NNP cord-010119-t1x9gknd 4715 24 Solution Solution NNP cord-010119-t1x9gknd 4715 25 ( ( -LRB- cord-010119-t1x9gknd 4715 26 PAS pas NN cord-010119-t1x9gknd 4715 27 ) ) -RRB- cord-010119-t1x9gknd 4715 28 and and CC cord-010119-t1x9gknd 4715 29 provide provide VB cord-010119-t1x9gknd 4715 30 additional additional JJ cord-010119-t1x9gknd 4715 31 improvements improvement NNS cord-010119-t1x9gknd 4715 32 to to TO cord-010119-t1x9gknd 4715 33 increase increase VB cord-010119-t1x9gknd 4715 34 overall overall JJ cord-010119-t1x9gknd 4715 35 reliability reliability NN cord-010119-t1x9gknd 4715 36 . . . cord-010119-t1x9gknd 4716 1 Additionally additionally RB cord-010119-t1x9gknd 4716 2 , , , cord-010119-t1x9gknd 4716 3 the the DT cord-010119-t1x9gknd 4716 4 manufacturer manufacturer NN cord-010119-t1x9gknd 4716 5 identified identify VBD cord-010119-t1x9gknd 4716 6 a a DT cord-010119-t1x9gknd 4716 7 slower slow JJR cord-010119-t1x9gknd 4716 8 centrifuge centrifuge NN cord-010119-t1x9gknd 4716 9 speed speed NN cord-010119-t1x9gknd 4716 10 at at IN cord-010119-t1x9gknd 4716 11 low low JJ cord-010119-t1x9gknd 4716 12 draw draw VB cord-010119-t1x9gknd 4716 13 flow flow NN cord-010119-t1x9gknd 4716 14 rates rate NNS cord-010119-t1x9gknd 4716 15 . . . cord-010119-t1x9gknd 4717 1 This this DT cord-010119-t1x9gknd 4717 2 software software NN cord-010119-t1x9gknd 4717 3 was be VBD cord-010119-t1x9gknd 4717 4 expected expect VBN cord-010119-t1x9gknd 4717 5 to to TO cord-010119-t1x9gknd 4717 6 function function VB cord-010119-t1x9gknd 4717 7 similarly similarly RB cord-010119-t1x9gknd 4717 8 to to IN cord-010119-t1x9gknd 4717 9 version version NN cord-010119-t1x9gknd 4717 10 6.0 6.0 CD cord-010119-t1x9gknd 4717 11 . . . cord-010119-t1x9gknd 4718 1 The the DT cord-010119-t1x9gknd 4718 2 objective objective NN cord-010119-t1x9gknd 4718 3 of of IN cord-010119-t1x9gknd 4718 4 this this DT cord-010119-t1x9gknd 4718 5 retrospective retrospective JJ cord-010119-t1x9gknd 4718 6 study study NN cord-010119-t1x9gknd 4718 7 is be VBZ cord-010119-t1x9gknd 4718 8 to to TO cord-010119-t1x9gknd 4718 9 identify identify VB cord-010119-t1x9gknd 4718 10 any any DT cord-010119-t1x9gknd 4718 11 variances variance NNS cord-010119-t1x9gknd 4718 12 with with IN cord-010119-t1x9gknd 4718 13 the the DT cord-010119-t1x9gknd 4718 14 software software NN cord-010119-t1x9gknd 4718 15 upgrade upgrade NN cord-010119-t1x9gknd 4718 16 influenced influence VBD cord-010119-t1x9gknd 4718 17 the the DT cord-010119-t1x9gknd 4718 18 plt plt NNP cord-010119-t1x9gknd 4718 19 products product NNS cord-010119-t1x9gknd 4718 20 collection collection NN cord-010119-t1x9gknd 4718 21 process process NN cord-010119-t1x9gknd 4718 22 or or CC cord-010119-t1x9gknd 4718 23 products product NNS cord-010119-t1x9gknd 4718 24 collected collect VBN cord-010119-t1x9gknd 4718 25 . . . cord-010119-t1x9gknd 4719 1 Study Study NNP cord-010119-t1x9gknd 4719 2 Design Design NNP cord-010119-t1x9gknd 4719 3 / / SYM cord-010119-t1x9gknd 4719 4 Methods method NNS cord-010119-t1x9gknd 4719 5 : : : cord-010119-t1x9gknd 4720 1 Prior prior RB cord-010119-t1x9gknd 4720 2 to to IN cord-010119-t1x9gknd 4720 3 1/16/2016 1/16/2016 CD cord-010119-t1x9gknd 4720 4 , , , cord-010119-t1x9gknd 4720 5 plt plt NNP cord-010119-t1x9gknd 4720 6 collections collection NNS cord-010119-t1x9gknd 4720 7 were be VBD cord-010119-t1x9gknd 4720 8 performed perform VBN cord-010119-t1x9gknd 4720 9 on on IN cord-010119-t1x9gknd 4720 10 nine nine CD cord-010119-t1x9gknd 4720 11 Trima Trima NNP cord-010119-t1x9gknd 4720 12 Accel Accel NNP cord-010119-t1x9gknd 4720 13 machines machine NNS cord-010119-t1x9gknd 4720 14 operating operate VBG cord-010119-t1x9gknd 4720 15 with with IN cord-010119-t1x9gknd 4720 16 version version NN cord-010119-t1x9gknd 4720 17 6.0 6.0 CD cord-010119-t1x9gknd 4720 18 . . . cord-010119-t1x9gknd 4721 1 Upgrading upgrade VBG cord-010119-t1x9gknd 4721 2 and and CC cord-010119-t1x9gknd 4721 3 validating validate VBG cord-010119-t1x9gknd 4721 4 all all DT cord-010119-t1x9gknd 4721 5 nine nine CD cord-010119-t1x9gknd 4721 6 machines machine NNS cord-010119-t1x9gknd 4721 7 to to IN cord-010119-t1x9gknd 4721 8 version version NN cord-010119-t1x9gknd 4721 9 6.4 6.4 CD cord-010119-t1x9gknd 4721 10 occurred occur VBD cord-010119-t1x9gknd 4721 11 from from IN cord-010119-t1x9gknd 4721 12 1/16/2016 1/16/2016 JJ cord-010119-t1x9gknd 4721 13 to to IN cord-010119-t1x9gknd 4721 14 4/30/ 4/30/ CD cord-010119-t1x9gknd 4721 15 2016 2016 CD cord-010119-t1x9gknd 4721 16 . . . cord-010119-t1x9gknd 4722 1 The the DT cord-010119-t1x9gknd 4722 2 Trimas Trimas NNP cord-010119-t1x9gknd 4722 3 were be VBD cord-010119-t1x9gknd 4722 4 programmed program VBN cord-010119-t1x9gknd 4722 5 with with IN cord-010119-t1x9gknd 4722 6 the the DT cord-010119-t1x9gknd 4722 7 same same JJ cord-010119-t1x9gknd 4722 8 plt plt NNP cord-010119-t1x9gknd 4722 9 configurations configuration NNS cord-010119-t1x9gknd 4722 10 both both CC cord-010119-t1x9gknd 4722 11 before before IN cord-010119-t1x9gknd 4722 12 and and CC cord-010119-t1x9gknd 4722 13 after after IN cord-010119-t1x9gknd 4722 14 software software NN cord-010119-t1x9gknd 4722 15 update update NN cord-010119-t1x9gknd 4722 16 . . . cord-010119-t1x9gknd 4723 1 Platelet platelet NN cord-010119-t1x9gknd 4723 2 collection collection NN cord-010119-t1x9gknd 4723 3 data datum NNS cord-010119-t1x9gknd 4723 4 from from IN cord-010119-t1x9gknd 4723 5 version version NN cord-010119-t1x9gknd 4723 6 6.0 6.0 CD cord-010119-t1x9gknd 4723 7 ( ( -LRB- cord-010119-t1x9gknd 4723 8 5/1/2015 5/1/2015 CD cord-010119-t1x9gknd 4723 9 to to IN cord-010119-t1x9gknd 4723 10 9/30/2015 9/30/2015 CD cord-010119-t1x9gknd 4723 11 ) ) -RRB- cord-010119-t1x9gknd 4723 12 was be VBD cord-010119-t1x9gknd 4723 13 compared compare VBN cord-010119-t1x9gknd 4723 14 to to IN cord-010119-t1x9gknd 4723 15 version version NN cord-010119-t1x9gknd 4723 16 6.4 6.4 CD cord-010119-t1x9gknd 4723 17 ( ( -LRB- cord-010119-t1x9gknd 4723 18 5/1/2016 5/1/2016 CD cord-010119-t1x9gknd 4723 19 to to IN cord-010119-t1x9gknd 4723 20 9/30/ 9/30/ CD cord-010119-t1x9gknd 4723 21 2016 2016 CD cord-010119-t1x9gknd 4723 22 ) ) -RRB- cord-010119-t1x9gknd 4723 23 . . . cord-010119-t1x9gknd 4724 1 Incomplete incomplete JJ cord-010119-t1x9gknd 4724 2 collections collection NNS cord-010119-t1x9gknd 4724 3 , , , cord-010119-t1x9gknd 4724 4 runs run NNS cord-010119-t1x9gknd 4724 5 identified identify VBN cord-010119-t1x9gknd 4724 6 as as IN cord-010119-t1x9gknd 4724 7 having have VBG cord-010119-t1x9gknd 4724 8 possible possible JJ cord-010119-t1x9gknd 4724 9 leukocyte leukocyte NN cord-010119-t1x9gknd 4724 10 contamination contamination NN cord-010119-t1x9gknd 4724 11 , , , cord-010119-t1x9gknd 4724 12 duration duration NN cord-010119-t1x9gknd 4724 13 of of IN cord-010119-t1x9gknd 4724 14 collection collection NN cord-010119-t1x9gknd 4724 15 , , , cord-010119-t1x9gknd 4724 16 and and CC cord-010119-t1x9gknd 4724 17 plt plt NNP cord-010119-t1x9gknd 4724 18 split split NN cord-010119-t1x9gknd 4724 19 rate rate NN cord-010119-t1x9gknd 4724 20 were be VBD cord-010119-t1x9gknd 4724 21 evaluated evaluate VBN cord-010119-t1x9gknd 4724 22 for for IN cord-010119-t1x9gknd 4724 23 each each DT cord-010119-t1x9gknd 4724 24 time time NN cord-010119-t1x9gknd 4724 25 period period NN cord-010119-t1x9gknd 4724 26 . . . cord-010119-t1x9gknd 4725 1 Generalized generalized JJ cord-010119-t1x9gknd 4725 2 estimating estimating NN cord-010119-t1x9gknd 4725 3 equations equation NNS cord-010119-t1x9gknd 4725 4 ( ( -LRB- cord-010119-t1x9gknd 4725 5 GEE GEE NNP cord-010119-t1x9gknd 4725 6 ) ) -RRB- cord-010119-t1x9gknd 4725 7 were be VBD cord-010119-t1x9gknd 4725 8 used use VBN cord-010119-t1x9gknd 4725 9 to to TO cord-010119-t1x9gknd 4725 10 assess assess VB cord-010119-t1x9gknd 4725 11 differences difference NNS cord-010119-t1x9gknd 4725 12 between between IN cord-010119-t1x9gknd 4725 13 plt plt NNP cord-010119-t1x9gknd 4725 14 collections collection NNS cord-010119-t1x9gknd 4725 15 with with IN cord-010119-t1x9gknd 4725 16 version version NN cord-010119-t1x9gknd 4725 17 6.0 6.0 CD cord-010119-t1x9gknd 4725 18 and and CC cord-010119-t1x9gknd 4725 19 6.4 6.4 CD cord-010119-t1x9gknd 4725 20 , , , cord-010119-t1x9gknd 4725 21 adjusting adjust VBG cord-010119-t1x9gknd 4725 22 for for IN cord-010119-t1x9gknd 4725 23 multiple multiple JJ cord-010119-t1x9gknd 4725 24 visits visit NNS cord-010119-t1x9gknd 4725 25 per per IN cord-010119-t1x9gknd 4725 26 donor donor NN cord-010119-t1x9gknd 4725 27 , , , cord-010119-t1x9gknd 4725 28 with with IN cord-010119-t1x9gknd 4725 29 significance significance NN cord-010119-t1x9gknd 4725 30 defined define VBN cord-010119-t1x9gknd 4725 31 as as IN cord-010119-t1x9gknd 4725 32 p p NN cord-010119-t1x9gknd 4725 33 - - HYPH cord-010119-t1x9gknd 4725 34 value value NN cord-010119-t1x9gknd 4725 35 < < XX cord-010119-t1x9gknd 4725 36 0.05 0.05 CD cord-010119-t1x9gknd 4725 37 . . . cord-010119-t1x9gknd 4726 1 Results result NNS cord-010119-t1x9gknd 4726 2 / / SYM cord-010119-t1x9gknd 4726 3 Findings finding NNS cord-010119-t1x9gknd 4726 4 : : : cord-010119-t1x9gknd 4727 1 Following follow VBG cord-010119-t1x9gknd 4727 2 the the DT cord-010119-t1x9gknd 4727 3 upgrade upgrade NN cord-010119-t1x9gknd 4727 4 to to IN cord-010119-t1x9gknd 4727 5 version version NN cord-010119-t1x9gknd 4727 6 6.4 6.4 CD cord-010119-t1x9gknd 4727 7 , , , cord-010119-t1x9gknd 4727 8 staff staff NN cord-010119-t1x9gknd 4727 9 observed observe VBD cord-010119-t1x9gknd 4727 10 a a DT cord-010119-t1x9gknd 4727 11 number number NN cord-010119-t1x9gknd 4727 12 of of IN cord-010119-t1x9gknd 4727 13 changes change NNS cord-010119-t1x9gknd 4727 14 including include VBG cord-010119-t1x9gknd 4727 15 an an DT cord-010119-t1x9gknd 4727 16 increased increase VBN cord-010119-t1x9gknd 4727 17 centrifuge centrifuge NN cord-010119-t1x9gknd 4727 18 recovery recovery NN cord-010119-t1x9gknd 4727 19 time time NN cord-010119-t1x9gknd 4727 20 on on IN cord-010119-t1x9gknd 4727 21 a a DT cord-010119-t1x9gknd 4727 22 donor donor NN cord-010119-t1x9gknd 4727 23 with with IN cord-010119-t1x9gknd 4727 24 a a DT cord-010119-t1x9gknd 4727 25 low low JJ cord-010119-t1x9gknd 4727 26 flow flow NN cord-010119-t1x9gknd 4727 27 and and CC cord-010119-t1x9gknd 4727 28 a a DT cord-010119-t1x9gknd 4727 29 notable notable JJ cord-010119-t1x9gknd 4727 30 increase increase NN cord-010119-t1x9gknd 4727 31 in in IN cord-010119-t1x9gknd 4727 32 possible possible JJ cord-010119-t1x9gknd 4727 33 leukocyte leukocyte NN cord-010119-t1x9gknd 4727 34 contamination contamination NN cord-010119-t1x9gknd 4727 35 products product NNS cord-010119-t1x9gknd 4727 36 . . . cord-010119-t1x9gknd 4728 1 Version version NN cord-010119-t1x9gknd 4728 2 6.4 6.4 CD cord-010119-t1x9gknd 4728 3 of of IN cord-010119-t1x9gknd 4728 4 the the DT cord-010119-t1x9gknd 4728 5 Trima Trima NNP cord-010119-t1x9gknd 4728 6 Accel Accel NNP cord-010119-t1x9gknd 4728 7 showed show VBD cord-010119-t1x9gknd 4728 8 a a DT cord-010119-t1x9gknd 4728 9 statistically statistically RB cord-010119-t1x9gknd 4728 10 significant significant JJ cord-010119-t1x9gknd 4728 11 increase increase NN cord-010119-t1x9gknd 4728 12 in in IN cord-010119-t1x9gknd 4728 13 possible possible JJ cord-010119-t1x9gknd 4728 14 leukocyte leukocyte NN cord-010119-t1x9gknd 4728 15 contamination contamination NN cord-010119-t1x9gknd 4728 16 from from IN cord-010119-t1x9gknd 4728 17 3 3 CD cord-010119-t1x9gknd 4728 18 % % NN cord-010119-t1x9gknd 4728 19 to to TO cord-010119-t1x9gknd 4728 20 5 5 CD cord-010119-t1x9gknd 4728 21 % % NN cord-010119-t1x9gknd 4728 22 of of IN cord-010119-t1x9gknd 4728 23 collections collection NNS cord-010119-t1x9gknd 4728 24 as as IN cord-010119-t1x9gknd 4728 25 compared compare VBN cord-010119-t1x9gknd 4728 26 with with IN cord-010119-t1x9gknd 4728 27 version version NN cord-010119-t1x9gknd 4728 28 6.0 6.0 CD cord-010119-t1x9gknd 4728 29 . . . cord-010119-t1x9gknd 4729 1 Both both DT cord-010119-t1x9gknd 4729 2 the the DT cord-010119-t1x9gknd 4729 3 duration duration NN cord-010119-t1x9gknd 4729 4 of of IN cord-010119-t1x9gknd 4729 5 collections collection NNS cord-010119-t1x9gknd 4729 6 and and CC cord-010119-t1x9gknd 4729 7 the the DT cord-010119-t1x9gknd 4729 8 plt plt NNP cord-010119-t1x9gknd 4729 9 split split NN cord-010119-t1x9gknd 4729 10 rate rate NN cord-010119-t1x9gknd 4729 11 remained remain VBD cord-010119-t1x9gknd 4729 12 constant constant JJ cord-010119-t1x9gknd 4729 13 even even RB cord-010119-t1x9gknd 4729 14 with with IN cord-010119-t1x9gknd 4729 15 centrifuge centrifuge NN cord-010119-t1x9gknd 4729 16 speed speed NN cord-010119-t1x9gknd 4729 17 adjustments adjustment NNS cord-010119-t1x9gknd 4729 18 in in IN cord-010119-t1x9gknd 4729 19 version version NN cord-010119-t1x9gknd 4729 20 6.4 6.4 CD cord-010119-t1x9gknd 4729 21 . . . cord-010119-t1x9gknd 4730 1 Conclusion conclusion NN cord-010119-t1x9gknd 4730 2 : : : cord-010119-t1x9gknd 4730 3 Due due IN cord-010119-t1x9gknd 4730 4 to to IN cord-010119-t1x9gknd 4730 5 FDA FDA NNP cord-010119-t1x9gknd 4730 6 limitations limitation NNS cord-010119-t1x9gknd 4730 7 not not RB cord-010119-t1x9gknd 4730 8 allowing allow VBG cord-010119-t1x9gknd 4730 9 for for IN cord-010119-t1x9gknd 4730 10 the the DT cord-010119-t1x9gknd 4730 11 implementation implementation NN cord-010119-t1x9gknd 4730 12 of of IN cord-010119-t1x9gknd 4730 13 Trima Trima NNP cord-010119-t1x9gknd 4730 14 Accel Accel NNP cord-010119-t1x9gknd 4730 15 PAS PAS NNP cord-010119-t1x9gknd 4730 16 plts plt NNS cord-010119-t1x9gknd 4730 17 with with IN cord-010119-t1x9gknd 4730 18 the the DT cord-010119-t1x9gknd 4730 19 currently currently RB cord-010119-t1x9gknd 4730 20 available available JJ cord-010119-t1x9gknd 4730 21 pathogen pathogen NN cord-010119-t1x9gknd 4730 22 reduction reduction NN cord-010119-t1x9gknd 4730 23 system system NN cord-010119-t1x9gknd 4730 24 , , , cord-010119-t1x9gknd 4730 25 the the DT cord-010119-t1x9gknd 4730 26 institution institution NN cord-010119-t1x9gknd 4730 27 decided decide VBD cord-010119-t1x9gknd 4730 28 to to TO cord-010119-t1x9gknd 4730 29 implement implement VB cord-010119-t1x9gknd 4730 30 only only RB cord-010119-t1x9gknd 4730 31 the the DT cord-010119-t1x9gknd 4730 32 pathogen pathogen NN cord-010119-t1x9gknd 4730 33 reduction reduction NN cord-010119-t1x9gknd 4730 34 system system NN cord-010119-t1x9gknd 4730 35 at at IN cord-010119-t1x9gknd 4730 36 this this DT cord-010119-t1x9gknd 4730 37 time time NN cord-010119-t1x9gknd 4730 38 . . . cord-010119-t1x9gknd 4731 1 Subsequently subsequently RB cord-010119-t1x9gknd 4731 2 , , , cord-010119-t1x9gknd 4731 3 the the DT cord-010119-t1x9gknd 4731 4 version version NN cord-010119-t1x9gknd 4731 5 6.4 6.4 CD cord-010119-t1x9gknd 4731 6 software software NN cord-010119-t1x9gknd 4731 7 is be VBZ cord-010119-t1x9gknd 4731 8 no no DT cord-010119-t1x9gknd 4731 9 longer long RBR cord-010119-t1x9gknd 4731 10 required require VBN cord-010119-t1x9gknd 4731 11 . . . cord-010119-t1x9gknd 4732 1 With with IN cord-010119-t1x9gknd 4732 2 the the DT cord-010119-t1x9gknd 4732 3 noted noted JJ cord-010119-t1x9gknd 4732 4 slight slight JJ cord-010119-t1x9gknd 4732 5 increase increase NN cord-010119-t1x9gknd 4732 6 in in IN cord-010119-t1x9gknd 4732 7 possible possible JJ cord-010119-t1x9gknd 4732 8 leukocyte leukocyte NN cord-010119-t1x9gknd 4732 9 contamination contamination NN cord-010119-t1x9gknd 4732 10 as as RB cord-010119-t1x9gknd 4732 11 well well RB cord-010119-t1x9gknd 4732 12 as as IN cord-010119-t1x9gknd 4732 13 the the DT cord-010119-t1x9gknd 4732 14 lack lack NN cord-010119-t1x9gknd 4732 15 of of IN cord-010119-t1x9gknd 4732 16 enhancements enhancement NNS cord-010119-t1x9gknd 4732 17 for for IN cord-010119-t1x9gknd 4732 18 plt plt NNP cord-010119-t1x9gknd 4732 19 collection collection NNP cord-010119-t1x9gknd 4732 20 , , , cord-010119-t1x9gknd 4732 21 the the DT cord-010119-t1x9gknd 4732 22 upgrade upgrade NN cord-010119-t1x9gknd 4732 23 to to IN cord-010119-t1x9gknd 4732 24 version version NN cord-010119-t1x9gknd 4732 25 6.4 6.4 CD cord-010119-t1x9gknd 4732 26 currently currently RB cord-010119-t1x9gknd 4732 27 does do VBZ cord-010119-t1x9gknd 4732 28 not not RB cord-010119-t1x9gknd 4732 29 provide provide VB cord-010119-t1x9gknd 4732 30 added add VBN cord-010119-t1x9gknd 4732 31 value value NN cord-010119-t1x9gknd 4732 32 over over IN cord-010119-t1x9gknd 4732 33 version version NN cord-010119-t1x9gknd 4732 34 6.0 6.0 CD cord-010119-t1x9gknd 4732 35 for for IN cord-010119-t1x9gknd 4732 36 plt plt NNP cord-010119-t1x9gknd 4732 37 collection collection NNP cord-010119-t1x9gknd 4732 38 . . . cord-010119-t1x9gknd 4733 1 pulmonary pulmonary JJ cord-010119-t1x9gknd 4733 2 and and CC cord-010119-t1x9gknd 4733 3 neurologic neurologic JJ cord-010119-t1x9gknd 4733 4 symptoms symptom NNS cord-010119-t1x9gknd 4733 5 due due JJ cord-010119-t1x9gknd 4733 6 to to IN cord-010119-t1x9gknd 4733 7 leukostasis leukostasis NNP cord-010119-t1x9gknd 4733 8 . . . cord-010119-t1x9gknd 4734 1 Therapeutic therapeutic JJ cord-010119-t1x9gknd 4734 2 Leukocytaphersis Leukocytaphersis NNP cord-010119-t1x9gknd 4734 3 ( ( -LRB- cord-010119-t1x9gknd 4734 4 TL TL NNP cord-010119-t1x9gknd 4734 5 ) ) -RRB- cord-010119-t1x9gknd 4734 6 is be VBZ cord-010119-t1x9gknd 4734 7 used use VBN cord-010119-t1x9gknd 4734 8 as as IN cord-010119-t1x9gknd 4734 9 an an DT cord-010119-t1x9gknd 4734 10 adjuvant adjuvant JJ cord-010119-t1x9gknd 4734 11 therapeutic therapeutic JJ cord-010119-t1x9gknd 4734 12 modality modality NN cord-010119-t1x9gknd 4734 13 in in IN cord-010119-t1x9gknd 4734 14 these these DT cord-010119-t1x9gknd 4734 15 patients patient NNS cord-010119-t1x9gknd 4734 16 with with IN cord-010119-t1x9gknd 4734 17 symptoms symptom NNS cord-010119-t1x9gknd 4734 18 suggestive suggestive JJ cord-010119-t1x9gknd 4734 19 of of IN cord-010119-t1x9gknd 4734 20 leukostasis leukostasis NNP cord-010119-t1x9gknd 4734 21 . . . cord-010119-t1x9gknd 4735 1 TL TL NNP cord-010119-t1x9gknd 4735 2 procedures procedure NNS cord-010119-t1x9gknd 4735 3 are be VBP cord-010119-t1x9gknd 4735 4 performed perform VBN cord-010119-t1x9gknd 4735 5 using use VBG cord-010119-t1x9gknd 4735 6 cell cell NN cord-010119-t1x9gknd 4735 7 separators separator NNS cord-010119-t1x9gknd 4735 8 where where WRB cord-010119-t1x9gknd 4735 9 anticoagulated anticoagulated JJ cord-010119-t1x9gknd 4735 10 blood blood NN cord-010119-t1x9gknd 4735 11 is be VBZ cord-010119-t1x9gknd 4735 12 subjected subject VBN cord-010119-t1x9gknd 4735 13 to to TO cord-010119-t1x9gknd 4735 14 centrifugal centrifugal VB cord-010119-t1x9gknd 4735 15 force force NN cord-010119-t1x9gknd 4735 16 resulting result VBG cord-010119-t1x9gknd 4735 17 in in IN cord-010119-t1x9gknd 4735 18 separate separate JJ cord-010119-t1x9gknd 4735 19 layers layer NNS cord-010119-t1x9gknd 4735 20 of of IN cord-010119-t1x9gknd 4735 21 cells cell NNS cord-010119-t1x9gknd 4735 22 and and CC cord-010119-t1x9gknd 4735 23 plasma plasma NN cord-010119-t1x9gknd 4735 24 depending depend VBG cord-010119-t1x9gknd 4735 25 on on IN cord-010119-t1x9gknd 4735 26 their -PRON- PRP$ cord-010119-t1x9gknd 4735 27 density density NN cord-010119-t1x9gknd 4735 28 . . . cord-010119-t1x9gknd 4736 1 There there EX cord-010119-t1x9gknd 4736 2 are be VBP cord-010119-t1x9gknd 4736 3 two two CD cord-010119-t1x9gknd 4736 4 programs program NNS cord-010119-t1x9gknd 4736 5 in in IN cord-010119-t1x9gknd 4736 6 the the DT cord-010119-t1x9gknd 4736 7 cell cell NN cord-010119-t1x9gknd 4736 8 separator separator NN cord-010119-t1x9gknd 4736 9 , , , cord-010119-t1x9gknd 4736 10 a a DT cord-010119-t1x9gknd 4736 11 mononuclear mononuclear NN cord-010119-t1x9gknd 4736 12 ( ( -LRB- cord-010119-t1x9gknd 4736 13 MNC)program mnc)program IN cord-010119-t1x9gknd 4736 14 which which WDT cord-010119-t1x9gknd 4736 15 has have VBZ cord-010119-t1x9gknd 4736 16 greater great JJR cord-010119-t1x9gknd 4736 17 centrifuge centrifuge NN cord-010119-t1x9gknd 4736 18 speed speed NN cord-010119-t1x9gknd 4736 19 and and CC cord-010119-t1x9gknd 4736 20 efficiency efficiency NN cord-010119-t1x9gknd 4736 21 for for IN cord-010119-t1x9gknd 4736 22 the the DT cord-010119-t1x9gknd 4736 23 collection collection NN cord-010119-t1x9gknd 4736 24 of of IN cord-010119-t1x9gknd 4736 25 MNCs mnc NNS cord-010119-t1x9gknd 4736 26 and and CC cord-010119-t1x9gknd 4736 27 a a DT cord-010119-t1x9gknd 4736 28 polymorphonuclear polymorphonuclear NN cord-010119-t1x9gknd 4736 29 ( ( -LRB- cord-010119-t1x9gknd 4736 30 PMN)cell pmn)cell UH cord-010119-t1x9gknd 4736 31 program program NN cord-010119-t1x9gknd 4736 32 with with IN cord-010119-t1x9gknd 4736 33 lower low JJR cord-010119-t1x9gknd 4736 34 centrifuge centrifuge NN cord-010119-t1x9gknd 4736 35 speed speed NN cord-010119-t1x9gknd 4736 36 for for IN cord-010119-t1x9gknd 4736 37 the the DT cord-010119-t1x9gknd 4736 38 collection collection NN cord-010119-t1x9gknd 4736 39 of of IN cord-010119-t1x9gknd 4736 40 PMNs pmn NNS cord-010119-t1x9gknd 4736 41 . . . cord-010119-t1x9gknd 4737 1 Hydroxyethyl Hydroxyethyl NNP cord-010119-t1x9gknd 4737 2 Starch(HES Starch(HES NNP cord-010119-t1x9gknd 4737 3 ) ) -RRB- cord-010119-t1x9gknd 4737 4 is be VBZ cord-010119-t1x9gknd 4737 5 preferred prefer VBN cord-010119-t1x9gknd 4737 6 for for IN cord-010119-t1x9gknd 4737 7 the the DT cord-010119-t1x9gknd 4737 8 collections collection NNS cord-010119-t1x9gknd 4737 9 of of IN cord-010119-t1x9gknd 4737 10 granulocytes granulocyte NNS cord-010119-t1x9gknd 4737 11 for for IN cord-010119-t1x9gknd 4737 12 transfusion transfusion NN cord-010119-t1x9gknd 4737 13 from from IN cord-010119-t1x9gknd 4737 14 healthy healthy JJ cord-010119-t1x9gknd 4737 15 donors donor NNS cord-010119-t1x9gknd 4737 16 . . . cord-010119-t1x9gknd 4738 1 Use use NN cord-010119-t1x9gknd 4738 2 of of IN cord-010119-t1x9gknd 4738 3 HES HES NNP cord-010119-t1x9gknd 4738 4 facilitates facilitate VBZ cord-010119-t1x9gknd 4738 5 the the DT cord-010119-t1x9gknd 4738 6 sedimentation sedimentation NN cord-010119-t1x9gknd 4738 7 of of IN cord-010119-t1x9gknd 4738 8 the the DT cord-010119-t1x9gknd 4738 9 granulocyte granulocyte NN cord-010119-t1x9gknd 4738 10 layer layer NN cord-010119-t1x9gknd 4738 11 and and CC cord-010119-t1x9gknd 4738 12 increases increase VBZ cord-010119-t1x9gknd 4738 13 the the DT cord-010119-t1x9gknd 4738 14 efficiency efficiency NN cord-010119-t1x9gknd 4738 15 of of IN cord-010119-t1x9gknd 4738 16 collection collection NN cord-010119-t1x9gknd 4738 17 . . . cord-010119-t1x9gknd 4739 1 Though though IN cord-010119-t1x9gknd 4739 2 use use NN cord-010119-t1x9gknd 4739 3 of of IN cord-010119-t1x9gknd 4739 4 HES HES NNP cord-010119-t1x9gknd 4739 5 in in IN cord-010119-t1x9gknd 4739 6 TL TL NNP cord-010119-t1x9gknd 4739 7 was be VBD cord-010119-t1x9gknd 4739 8 not not RB cord-010119-t1x9gknd 4739 9 associated associate VBN cord-010119-t1x9gknd 4739 10 with with IN cord-010119-t1x9gknd 4739 11 adverse adverse JJ cord-010119-t1x9gknd 4739 12 events event NNS cord-010119-t1x9gknd 4739 13 with with IN cord-010119-t1x9gknd 4739 14 its -PRON- PRP$ cord-010119-t1x9gknd 4739 15 use use NN cord-010119-t1x9gknd 4739 16 as as IN cord-010119-t1x9gknd 4739 17 a a DT cord-010119-t1x9gknd 4739 18 volume volume NN cord-010119-t1x9gknd 4739 19 expander expander NN cord-010119-t1x9gknd 4739 20 ( ( -LRB- cord-010119-t1x9gknd 4739 21 Pagano Pagano NNP cord-010119-t1x9gknd 4739 22 ) ) -RRB- cord-010119-t1x9gknd 4740 1 its -PRON- PRP$ cord-010119-t1x9gknd 4740 2 use use NN cord-010119-t1x9gknd 4740 3 in in IN cord-010119-t1x9gknd 4740 4 TL TL NNP cord-010119-t1x9gknd 4740 5 varies vary VBZ cord-010119-t1x9gknd 4740 6 and and CC cord-010119-t1x9gknd 4740 7 no no DT cord-010119-t1x9gknd 4740 8 reports report NNS cord-010119-t1x9gknd 4740 9 are be VBP cord-010119-t1x9gknd 4740 10 available available JJ cord-010119-t1x9gknd 4740 11 on on IN cord-010119-t1x9gknd 4740 12 the the DT cord-010119-t1x9gknd 4740 13 efficiency efficiency NN cord-010119-t1x9gknd 4740 14 of of IN cord-010119-t1x9gknd 4740 15 leukodepletion leukodepletion NN cord-010119-t1x9gknd 4740 16 using use VBG cord-010119-t1x9gknd 4740 17 HES HES NNP cord-010119-t1x9gknd 4740 18 for for IN cord-010119-t1x9gknd 4740 19 TL TL NNP cord-010119-t1x9gknd 4740 20 . . . cord-010119-t1x9gknd 4741 1 Study Study NNP cord-010119-t1x9gknd 4741 2 Design Design NNP cord-010119-t1x9gknd 4741 3 / / SYM cord-010119-t1x9gknd 4741 4 Method method NN cord-010119-t1x9gknd 4741 5 : : : cord-010119-t1x9gknd 4741 6 We -PRON- PRP cord-010119-t1x9gknd 4741 7 received receive VBD cord-010119-t1x9gknd 4741 8 a a DT cord-010119-t1x9gknd 4741 9 request request NN cord-010119-t1x9gknd 4741 10 for for IN cord-010119-t1x9gknd 4741 11 leukoreduction leukoreduction NN cord-010119-t1x9gknd 4741 12 in in IN cord-010119-t1x9gknd 4741 13 32 32 CD cord-010119-t1x9gknd 4741 14 yearold yearold JJ cord-010119-t1x9gknd 4741 15 lady lady NN cord-010119-t1x9gknd 4741 16 with with IN cord-010119-t1x9gknd 4741 17 chronic chronic JJ cord-010119-t1x9gknd 4741 18 myelogenous myelogenous NN cord-010119-t1x9gknd 4741 19 leukemia leukemia NN cord-010119-t1x9gknd 4741 20 ( ( -LRB- cord-010119-t1x9gknd 4741 21 CML CML NNP cord-010119-t1x9gknd 4741 22 ) ) -RRB- cord-010119-t1x9gknd 4741 23 who who WP cord-010119-t1x9gknd 4741 24 had have VBD cord-010119-t1x9gknd 4741 25 a a DT cord-010119-t1x9gknd 4741 26 good good JJ cord-010119-t1x9gknd 4741 27 response response NN cord-010119-t1x9gknd 4741 28 to to IN cord-010119-t1x9gknd 4741 29 Imatinib Imatinib NNP cord-010119-t1x9gknd 4741 30 . . . cord-010119-t1x9gknd 4742 1 She -PRON- PRP cord-010119-t1x9gknd 4742 2 is be VBZ cord-010119-t1x9gknd 4742 3 30 30 CD cord-010119-t1x9gknd 4742 4 weeks week NNS cord-010119-t1x9gknd 4742 5 pregnant pregnant JJ cord-010119-t1x9gknd 4742 6 with with IN cord-010119-t1x9gknd 4742 7 an an DT cord-010119-t1x9gknd 4742 8 increased increase VBN cord-010119-t1x9gknd 4742 9 WBC WBC NNP cord-010119-t1x9gknd 4742 10 count count NN cord-010119-t1x9gknd 4742 11 due due IN cord-010119-t1x9gknd 4742 12 to to IN cord-010119-t1x9gknd 4742 13 the the DT cord-010119-t1x9gknd 4742 14 discontinuation discontinuation NN cord-010119-t1x9gknd 4742 15 of of IN cord-010119-t1x9gknd 4742 16 Imatinib Imatinib NNP cord-010119-t1x9gknd 4742 17 . . . cord-010119-t1x9gknd 4743 1 We -PRON- PRP cord-010119-t1x9gknd 4743 2 performed perform VBD cord-010119-t1x9gknd 4743 3 TL TL NNP cord-010119-t1x9gknd 4743 4 with with IN cord-010119-t1x9gknd 4743 5 the the DT cord-010119-t1x9gknd 4743 6 COBE COBE NNP cord-010119-t1x9gknd 4743 7 Spectra Spectra NNP cord-010119-t1x9gknd 4743 8 using use VBG cord-010119-t1x9gknd 4743 9 a a DT cord-010119-t1x9gknd 4743 10 replacement replacement NN cord-010119-t1x9gknd 4743 11 fluid fluid NN cord-010119-t1x9gknd 4743 12 of of IN cord-010119-t1x9gknd 4743 13 500 500 CD cord-010119-t1x9gknd 4743 14 ml ml NN cord-010119-t1x9gknd 4743 15 5 5 CD cord-010119-t1x9gknd 4743 16 % % NN cord-010119-t1x9gknd 4743 17 albumin albumin NN cord-010119-t1x9gknd 4743 18 . . . cord-010119-t1x9gknd 4744 1 WBC WBC NNP cord-010119-t1x9gknd 4744 2 counts count NNS cord-010119-t1x9gknd 4744 3 were be VBD cord-010119-t1x9gknd 4744 4 monitored monitor VBN cord-010119-t1x9gknd 4744 5 pre pre JJ cord-010119-t1x9gknd 4744 6 and and CC cord-010119-t1x9gknd 4744 7 post post VB cord-010119-t1x9gknd 4744 8 TL TL NNP cord-010119-t1x9gknd 4744 9 in in IN cord-010119-t1x9gknd 4744 10 the the DT cord-010119-t1x9gknd 4744 11 patient patient NN cord-010119-t1x9gknd 4744 12 and and CC cord-010119-t1x9gknd 4744 13 in in IN cord-010119-t1x9gknd 4744 14 the the DT cord-010119-t1x9gknd 4744 15 collected collect VBN cord-010119-t1x9gknd 4744 16 product product NN cord-010119-t1x9gknd 4744 17 . . . cord-010119-t1x9gknd 4745 1 We -PRON- PRP cord-010119-t1x9gknd 4745 2 modified modify VBD cord-010119-t1x9gknd 4745 3 the the DT cord-010119-t1x9gknd 4745 4 collection collection NN cord-010119-t1x9gknd 4745 5 based base VBN cord-010119-t1x9gknd 4745 6 on on IN cord-010119-t1x9gknd 4745 7 these these DT cord-010119-t1x9gknd 4745 8 results result NNS cord-010119-t1x9gknd 4745 9 using use VBG cord-010119-t1x9gknd 4745 10 the the DT cord-010119-t1x9gknd 4745 11 MNC MNC NNP cord-010119-t1x9gknd 4745 12 program program NN cord-010119-t1x9gknd 4745 13 with with IN cord-010119-t1x9gknd 4745 14 ACD ACD NNP cord-010119-t1x9gknd 4745 15 - - HYPH cord-010119-t1x9gknd 4745 16 A A NNP cord-010119-t1x9gknd 4745 17 or or CC cord-010119-t1x9gknd 4745 18 the the DT cord-010119-t1x9gknd 4745 19 PMN PMN NNP cord-010119-t1x9gknd 4745 20 program program NN cord-010119-t1x9gknd 4745 21 with with IN cord-010119-t1x9gknd 4745 22 ACD ACD NNP cord-010119-t1x9gknd 4745 23 - - HYPH cord-010119-t1x9gknd 4745 24 A a NN cord-010119-t1x9gknd 4745 25 . . . cord-010119-t1x9gknd 4746 1 As as IN cord-010119-t1x9gknd 4746 2 leukodepetion leukodepetion NN cord-010119-t1x9gknd 4746 3 was be VBD cord-010119-t1x9gknd 4746 4 not not RB cord-010119-t1x9gknd 4746 5 adequate adequate JJ cord-010119-t1x9gknd 4746 6 with with IN cord-010119-t1x9gknd 4746 7 these these DT cord-010119-t1x9gknd 4746 8 programs program NNS cord-010119-t1x9gknd 4746 9 we -PRON- PRP cord-010119-t1x9gknd 4746 10 elected elect VBD cord-010119-t1x9gknd 4746 11 to to TO cord-010119-t1x9gknd 4746 12 use use VB cord-010119-t1x9gknd 4746 13 HES HES NNP cord-010119-t1x9gknd 4746 14 after after IN cord-010119-t1x9gknd 4746 15 discussion discussion NN cord-010119-t1x9gknd 4746 16 with with IN cord-010119-t1x9gknd 4746 17 the the DT cord-010119-t1x9gknd 4746 18 patient patient NN cord-010119-t1x9gknd 4746 19 and and CC cord-010119-t1x9gknd 4746 20 her -PRON- PRP$ cord-010119-t1x9gknd 4746 21 physician physician NN cord-010119-t1x9gknd 4746 22 . . . cord-010119-t1x9gknd 4747 1 TL TL NNP cord-010119-t1x9gknd 4747 2 was be VBD cord-010119-t1x9gknd 4747 3 performed perform VBN cord-010119-t1x9gknd 4747 4 using use VBG cord-010119-t1x9gknd 4747 5 500 500 CD cord-010119-t1x9gknd 4747 6 ml ml NNS cord-010119-t1x9gknd 4747 7 of of IN cord-010119-t1x9gknd 4747 8 HES HES NNP cord-010119-t1x9gknd 4747 9 with with IN cord-010119-t1x9gknd 4747 10 citrate citrate NN cord-010119-t1x9gknd 4747 11 and and CC cord-010119-t1x9gknd 4747 12 the the DT cord-010119-t1x9gknd 4747 13 PMN PMN NNP cord-010119-t1x9gknd 4747 14 program program NN cord-010119-t1x9gknd 4747 15 . . . cord-010119-t1x9gknd 4748 1 WBC WBC NNP cord-010119-t1x9gknd 4748 2 pre pre VBD cord-010119-t1x9gknd 4748 3 procedure procedure NN cord-010119-t1x9gknd 4748 4 , , , cord-010119-t1x9gknd 4748 5 immediate immediate JJ cord-010119-t1x9gknd 4748 6 post post NN cord-010119-t1x9gknd 4748 7 procedure procedure NN cord-010119-t1x9gknd 4748 8 and and CC cord-010119-t1x9gknd 4748 9 the the DT cord-010119-t1x9gknd 4748 10 product product NN cord-010119-t1x9gknd 4748 11 was be VBD cord-010119-t1x9gknd 4748 12 obtained obtain VBN cord-010119-t1x9gknd 4748 13 and and CC cord-010119-t1x9gknd 4748 14 the the DT cord-010119-t1x9gknd 4748 15 efficiency efficiency NN cord-010119-t1x9gknd 4748 16 of of IN cord-010119-t1x9gknd 4748 17 leukodepletion leukodepletion NN cord-010119-t1x9gknd 4748 18 with with IN cord-010119-t1x9gknd 4748 19 the the DT cord-010119-t1x9gknd 4748 20 different different JJ cord-010119-t1x9gknd 4748 21 programs program NNS cord-010119-t1x9gknd 4748 22 was be VBD cord-010119-t1x9gknd 4748 23 calculated calculate VBN cord-010119-t1x9gknd 4748 24 . . . cord-010119-t1x9gknd 4749 1 Results result NNS cord-010119-t1x9gknd 4749 2 / / SYM cord-010119-t1x9gknd 4749 3 Finding finding NN cord-010119-t1x9gknd 4749 4 : : : cord-010119-t1x9gknd 4749 5 The the DT cord-010119-t1x9gknd 4749 6 efficiency efficiency NN cord-010119-t1x9gknd 4749 7 of of IN cord-010119-t1x9gknd 4749 8 % % NN cord-010119-t1x9gknd 4749 9 WBC WBC NNP cord-010119-t1x9gknd 4749 10 depletion depletion NN cord-010119-t1x9gknd 4749 11 was be VBD cord-010119-t1x9gknd 4749 12 calculated calculate VBN cord-010119-t1x9gknd 4749 13 by by IN cord-010119-t1x9gknd 4749 14 product product NN cord-010119-t1x9gknd 4749 15 WBC WBC NNP cord-010119-t1x9gknd 4749 16 to to TO cord-010119-t1x9gknd 4749 17 patient patient VB cord-010119-t1x9gknd 4749 18 WBC WBC NNP cord-010119-t1x9gknd 4749 19 based base VBN cord-010119-t1x9gknd 4749 20 on on IN cord-010119-t1x9gknd 4749 21 blood blood NN cord-010119-t1x9gknd 4749 22 volume volume NN cord-010119-t1x9gknd 4749 23 and and CC cord-010119-t1x9gknd 4749 24 also also RB cord-010119-t1x9gknd 4749 25 Pre pre VB cord-010119-t1x9gknd 4749 26 to to IN cord-010119-t1x9gknd 4749 27 Post Post NNP cord-010119-t1x9gknd 4749 28 WBC WBC NNP cord-010119-t1x9gknd 4750 1 The the DT cord-010119-t1x9gknd 4750 2 patient patient NN cord-010119-t1x9gknd 4750 3 tolerated tolerate VBD cord-010119-t1x9gknd 4750 4 the the DT cord-010119-t1x9gknd 4750 5 procedures procedure NNS cord-010119-t1x9gknd 4750 6 well well RB cord-010119-t1x9gknd 4750 7 and and CC cord-010119-t1x9gknd 4750 8 there there EX cord-010119-t1x9gknd 4750 9 were be VBD cord-010119-t1x9gknd 4750 10 no no DT cord-010119-t1x9gknd 4750 11 adverse adverse JJ cord-010119-t1x9gknd 4750 12 reactions reaction NNS cord-010119-t1x9gknd 4750 13 in in IN cord-010119-t1x9gknd 4750 14 the the DT cord-010119-t1x9gknd 4750 15 patient patient NN cord-010119-t1x9gknd 4750 16 and and CC cord-010119-t1x9gknd 4750 17 in in IN cord-010119-t1x9gknd 4750 18 fetal fetal JJ cord-010119-t1x9gknd 4750 19 monitoring monitoring NN cord-010119-t1x9gknd 4750 20 during during IN cord-010119-t1x9gknd 4750 21 the the DT cord-010119-t1x9gknd 4750 22 procedures procedure NNS cord-010119-t1x9gknd 4750 23 Conclusion conclusion NN cord-010119-t1x9gknd 4750 24 : : : cord-010119-t1x9gknd 4750 25 Therapeutic therapeutic JJ cord-010119-t1x9gknd 4750 26 leukocytapheresis leukocytapheresis NN cord-010119-t1x9gknd 4750 27 in in IN cord-010119-t1x9gknd 4750 28 CML CML NNP cord-010119-t1x9gknd 4750 29 patients patient NNS cord-010119-t1x9gknd 4750 30 is be VBZ cord-010119-t1x9gknd 4750 31 safe safe JJ cord-010119-t1x9gknd 4750 32 and and CC cord-010119-t1x9gknd 4750 33 more more RBR cord-010119-t1x9gknd 4750 34 effective effective JJ cord-010119-t1x9gknd 4750 35 in in IN cord-010119-t1x9gknd 4750 36 reducing reduce VBG cord-010119-t1x9gknd 4750 37 the the DT cord-010119-t1x9gknd 4750 38 WBC WBC NNP cord-010119-t1x9gknd 4750 39 count count NN cord-010119-t1x9gknd 4750 40 with with IN cord-010119-t1x9gknd 4750 41 the the DT cord-010119-t1x9gknd 4750 42 use use NN cord-010119-t1x9gknd 4750 43 of of IN cord-010119-t1x9gknd 4750 44 500 500 CD cord-010119-t1x9gknd 4750 45 ml ml NNS cord-010119-t1x9gknd 4750 46 of of IN cord-010119-t1x9gknd 4750 47 hydroxyethyl hydroxyethyl NN cord-010119-t1x9gknd 4750 48 starch starch NN cord-010119-t1x9gknd 4750 49 with with IN cord-010119-t1x9gknd 4750 50 anticoagulant anticoagulant NN cord-010119-t1x9gknd 4750 51 . . . cord-010119-t1x9gknd 4751 1 Post post JJ cord-010119-t1x9gknd 4751 2 procedure procedure NN cord-010119-t1x9gknd 4751 3 patient patient NN cord-010119-t1x9gknd 4751 4 WBC WBC NNP cord-010119-t1x9gknd 4751 5 counts count VBZ cord-010119-t1x9gknd 4751 6 sometimes sometimes RB cord-010119-t1x9gknd 4751 7 may may MD cord-010119-t1x9gknd 4751 8 not not RB cord-010119-t1x9gknd 4751 9 provide provide VB cord-010119-t1x9gknd 4751 10 the the DT cord-010119-t1x9gknd 4751 11 data datum NNS cord-010119-t1x9gknd 4751 12 on on IN cord-010119-t1x9gknd 4751 13 the the DT cord-010119-t1x9gknd 4751 14 efficiency efficiency NN cord-010119-t1x9gknd 4751 15 of of IN cord-010119-t1x9gknd 4751 16 leucodepletion leucodepletion NN cord-010119-t1x9gknd 4751 17 . . . cord-010119-t1x9gknd 4751 18 _SP cord-010119-t1x9gknd 4752 1 Background Background NNP cord-010119-t1x9gknd 4752 2 / / SYM cord-010119-t1x9gknd 4752 3 Case Case NNP cord-010119-t1x9gknd 4752 4 Studies Studies NNPS cord-010119-t1x9gknd 4752 5 : : : cord-010119-t1x9gknd 4753 1 Early early JJ cord-010119-t1x9gknd 4753 2 recognition recognition NN cord-010119-t1x9gknd 4753 3 of of IN cord-010119-t1x9gknd 4753 4 hypertriglyceridemia hypertriglyceridemia NN cord-010119-t1x9gknd 4753 5 ( ( -LRB- cord-010119-t1x9gknd 4753 6 HTG HTG NNP cord-010119-t1x9gknd 4753 7 ) ) -RRB- cord-010119-t1x9gknd 4753 8 in in IN cord-010119-t1x9gknd 4753 9 the the DT cord-010119-t1x9gknd 4753 10 setting setting NN cord-010119-t1x9gknd 4753 11 of of IN cord-010119-t1x9gknd 4753 12 acute acute JJ cord-010119-t1x9gknd 4753 13 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4753 14 ( ( -LRB- cord-010119-t1x9gknd 4753 15 AP AP NNP cord-010119-t1x9gknd 4753 16 ) ) -RRB- cord-010119-t1x9gknd 4753 17 is be VBZ cord-010119-t1x9gknd 4753 18 critical critical JJ cord-010119-t1x9gknd 4753 19 to to TO cord-010119-t1x9gknd 4753 20 initiate initiate VB cord-010119-t1x9gknd 4753 21 effective effective JJ cord-010119-t1x9gknd 4753 22 therapy therapy NN cord-010119-t1x9gknd 4753 23 . . . cord-010119-t1x9gknd 4754 1 The the DT cord-010119-t1x9gknd 4754 2 role role NN cord-010119-t1x9gknd 4754 3 of of IN cord-010119-t1x9gknd 4754 4 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 4754 5 as as IN cord-010119-t1x9gknd 4754 6 an an DT cord-010119-t1x9gknd 4754 7 early early JJ cord-010119-t1x9gknd 4754 8 / / SYM cord-010119-t1x9gknd 4754 9 adjuvant adjuvant NN cord-010119-t1x9gknd 4754 10 approach approach NN cord-010119-t1x9gknd 4754 11 in in IN cord-010119-t1x9gknd 4754 12 acute acute JJ cord-010119-t1x9gknd 4754 13 HTG htg NN cord-010119-t1x9gknd 4754 14 - - HYPH cord-010119-t1x9gknd 4754 15 induced induce VBN cord-010119-t1x9gknd 4754 16 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4754 17 is be VBZ cord-010119-t1x9gknd 4754 18 controversial controversial JJ cord-010119-t1x9gknd 4754 19 . . . cord-010119-t1x9gknd 4755 1 Currently currently RB cord-010119-t1x9gknd 4755 2 , , , cord-010119-t1x9gknd 4755 3 there there EX cord-010119-t1x9gknd 4755 4 are be VBP cord-010119-t1x9gknd 4755 5 no no DT cord-010119-t1x9gknd 4755 6 consensus consensus NN cord-010119-t1x9gknd 4755 7 guidelines guideline NNS cord-010119-t1x9gknd 4755 8 in in IN cord-010119-t1x9gknd 4755 9 optimal optimal JJ cord-010119-t1x9gknd 4755 10 therapy therapy NN cord-010119-t1x9gknd 4755 11 and and CC cord-010119-t1x9gknd 4755 12 is be VBZ cord-010119-t1x9gknd 4755 13 ASFA ASFA NNP cord-010119-t1x9gknd 4755 14 category category NN cord-010119-t1x9gknd 4755 15 III III NNP cord-010119-t1x9gknd 4755 16 . . . cord-010119-t1x9gknd 4756 1 Reported report VBN cord-010119-t1x9gknd 4756 2 here here RB cord-010119-t1x9gknd 4756 3 is be VBZ cord-010119-t1x9gknd 4756 4 a a DT cord-010119-t1x9gknd 4756 5 case case NN cord-010119-t1x9gknd 4756 6 where where WRB cord-010119-t1x9gknd 4756 7 the the DT cord-010119-t1x9gknd 4756 8 TG TG NNP cord-010119-t1x9gknd 4756 9 level level NN cord-010119-t1x9gknd 4756 10 as as RB cord-010119-t1x9gknd 4756 11 well well RB cord-010119-t1x9gknd 4756 12 as as IN cord-010119-t1x9gknd 4756 13 clinical clinical JJ cord-010119-t1x9gknd 4756 14 symptoms symptom NNS cord-010119-t1x9gknd 4756 15 improved improve VBD cord-010119-t1x9gknd 4756 16 after after IN cord-010119-t1x9gknd 4756 17 one one CD cord-010119-t1x9gknd 4756 18 therapeutic therapeutic JJ cord-010119-t1x9gknd 4756 19 plasma plasma NN cord-010119-t1x9gknd 4756 20 exchange exchange NN cord-010119-t1x9gknd 4756 21 ( ( -LRB- cord-010119-t1x9gknd 4756 22 TPE TPE NNP cord-010119-t1x9gknd 4756 23 ) ) -RRB- cord-010119-t1x9gknd 4756 24 . . . cord-010119-t1x9gknd 4757 1 Study Study NNP cord-010119-t1x9gknd 4757 2 Design Design NNP cord-010119-t1x9gknd 4757 3 / / SYM cord-010119-t1x9gknd 4757 4 Method method NN cord-010119-t1x9gknd 4757 5 : : : cord-010119-t1x9gknd 4758 1 A a DT cord-010119-t1x9gknd 4758 2 45 45 CD cord-010119-t1x9gknd 4758 3 years year NNS cord-010119-t1x9gknd 4758 4 old old JJ cord-010119-t1x9gknd 4758 5 male male NN cord-010119-t1x9gknd 4758 6 with with IN cord-010119-t1x9gknd 4758 7 history history NN cord-010119-t1x9gknd 4758 8 of of IN cord-010119-t1x9gknd 4758 9 hypertension hypertension NN cord-010119-t1x9gknd 4758 10 , , , cord-010119-t1x9gknd 4758 11 HTG HTG NNP cord-010119-t1x9gknd 4758 12 , , , cord-010119-t1x9gknd 4758 13 and and CC cord-010119-t1x9gknd 4758 14 Diabetes diabetes NN cord-010119-t1x9gknd 4758 15 Mellitus mellitus NN cord-010119-t1x9gknd 4758 16 ( ( -LRB- cord-010119-t1x9gknd 4758 17 DM DM NNP cord-010119-t1x9gknd 4758 18 ) ) -RRB- cord-010119-t1x9gknd 4758 19 presented present VBN cord-010119-t1x9gknd 4758 20 to to IN cord-010119-t1x9gknd 4758 21 our -PRON- PRP$ cord-010119-t1x9gknd 4758 22 emergency emergency NN cord-010119-t1x9gknd 4758 23 department department NN cord-010119-t1x9gknd 4758 24 with with IN cord-010119-t1x9gknd 4758 25 excruciating excruciating JJ cord-010119-t1x9gknd 4758 26 abdominal abdominal JJ cord-010119-t1x9gknd 4758 27 pain pain NN cord-010119-t1x9gknd 4758 28 . . . cord-010119-t1x9gknd 4759 1 The the DT cord-010119-t1x9gknd 4759 2 patient patient NN cord-010119-t1x9gknd 4759 3 was be VBD cord-010119-t1x9gknd 4759 4 diagnosed diagnose VBN cord-010119-t1x9gknd 4759 5 with with IN cord-010119-t1x9gknd 4759 6 HTG HTG NNP cord-010119-t1x9gknd 4759 7 at at IN cord-010119-t1x9gknd 4759 8 20 20 CD cord-010119-t1x9gknd 4759 9 years year NNS cord-010119-t1x9gknd 4759 10 old old JJ cord-010119-t1x9gknd 4759 11 . . . cord-010119-t1x9gknd 4760 1 He -PRON- PRP cord-010119-t1x9gknd 4760 2 was be VBD cord-010119-t1x9gknd 4760 3 treated treat VBN cord-010119-t1x9gknd 4760 4 initially initially RB cord-010119-t1x9gknd 4760 5 with with IN cord-010119-t1x9gknd 4760 6 diet diet NN cord-010119-t1x9gknd 4760 7 and and CC cord-010119-t1x9gknd 4760 8 lifestyle lifestyle NN cord-010119-t1x9gknd 4760 9 modification modification NN cord-010119-t1x9gknd 4760 10 . . . cord-010119-t1x9gknd 4761 1 However however RB cord-010119-t1x9gknd 4761 2 , , , cord-010119-t1x9gknd 4761 3 his -PRON- PRP$ cord-010119-t1x9gknd 4761 4 clinical clinical JJ cord-010119-t1x9gknd 4761 5 course course NN cord-010119-t1x9gknd 4761 6 has have VBZ cord-010119-t1x9gknd 4761 7 been be VBN cord-010119-t1x9gknd 4761 8 compromised compromise VBN cord-010119-t1x9gknd 4761 9 after after IN cord-010119-t1x9gknd 4761 10 developing develop VBG cord-010119-t1x9gknd 4761 11 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4761 12 with with IN cord-010119-t1x9gknd 4761 13 3 3 CD cord-010119-t1x9gknd 4761 14 acute acute JJ cord-010119-t1x9gknd 4761 15 episodes episode NNS cord-010119-t1x9gknd 4761 16 requiring require VBG cord-010119-t1x9gknd 4761 17 prolong prolong JJ cord-010119-t1x9gknd 4761 18 hospital hospital NN cord-010119-t1x9gknd 4761 19 admission admission NN cord-010119-t1x9gknd 4761 20 of of IN cord-010119-t1x9gknd 4761 21 approximately approximately RB cord-010119-t1x9gknd 4761 22 2 2 CD cord-010119-t1x9gknd 4761 23 months month NNS cord-010119-t1x9gknd 4762 1 each each DT cord-010119-t1x9gknd 4762 2 which which WDT cord-010119-t1x9gknd 4762 3 were be VBD cord-010119-t1x9gknd 4762 4 successfully successfully RB cord-010119-t1x9gknd 4762 5 treated treat VBN cord-010119-t1x9gknd 4762 6 medically medically RB cord-010119-t1x9gknd 4762 7 . . . cord-010119-t1x9gknd 4763 1 However however RB cord-010119-t1x9gknd 4763 2 , , , cord-010119-t1x9gknd 4763 3 the the DT cord-010119-t1x9gknd 4763 4 recurrent recurrent JJ cord-010119-t1x9gknd 4763 5 episodes episode NNS cord-010119-t1x9gknd 4763 6 resulted result VBD cord-010119-t1x9gknd 4763 7 in in IN cord-010119-t1x9gknd 4763 8 chronic chronic JJ cord-010119-t1x9gknd 4763 9 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4763 10 which which WDT cord-010119-t1x9gknd 4763 11 was be VBD cord-010119-t1x9gknd 4763 12 complicated complicate VBN cord-010119-t1x9gknd 4763 13 with with IN cord-010119-t1x9gknd 4763 14 pancreatic pancreatic JJ cord-010119-t1x9gknd 4763 15 pseudocyst pseudocyst NN cord-010119-t1x9gknd 4763 16 and and CC cord-010119-t1x9gknd 4763 17 pancreatic pancreatic JJ cord-010119-t1x9gknd 4763 18 insufficiency insufficiency NN cord-010119-t1x9gknd 4763 19 . . . cord-010119-t1x9gknd 4764 1 Since since IN cord-010119-t1x9gknd 4764 2 the the DT cord-010119-t1x9gknd 4764 3 first first JJ cord-010119-t1x9gknd 4764 4 episode episode NN cord-010119-t1x9gknd 4764 5 of of IN cord-010119-t1x9gknd 4764 6 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4764 7 , , , cord-010119-t1x9gknd 4764 8 he -PRON- PRP cord-010119-t1x9gknd 4764 9 was be VBD cord-010119-t1x9gknd 4764 10 then then RB cord-010119-t1x9gknd 4764 11 medically medically RB cord-010119-t1x9gknd 4764 12 managed manage VBN cord-010119-t1x9gknd 4764 13 with with IN cord-010119-t1x9gknd 4764 14 fenofibrate fenofibrate NN cord-010119-t1x9gknd 4764 15 , , , cord-010119-t1x9gknd 4764 16 Lovaza Lovaza NNP cord-010119-t1x9gknd 4764 17 , , , cord-010119-t1x9gknd 4764 18 Lisinopril Lisinopril NNP cord-010119-t1x9gknd 4764 19 , , , cord-010119-t1x9gknd 4764 20 Levemir Levemir NNP cord-010119-t1x9gknd 4764 21 and and CC cord-010119-t1x9gknd 4764 22 NovoLog NovoLog NNP cord-010119-t1x9gknd 4764 23 . . . cord-010119-t1x9gknd 4765 1 During during IN cord-010119-t1x9gknd 4765 2 evaluation evaluation NN cord-010119-t1x9gknd 4765 3 on on IN cord-010119-t1x9gknd 4765 4 current current JJ cord-010119-t1x9gknd 4765 5 admission admission NN cord-010119-t1x9gknd 4765 6 , , , cord-010119-t1x9gknd 4765 7 he -PRON- PRP cord-010119-t1x9gknd 4765 8 was be VBD cord-010119-t1x9gknd 4765 9 found find VBN cord-010119-t1x9gknd 4765 10 to to TO cord-010119-t1x9gknd 4765 11 have have VB cord-010119-t1x9gknd 4765 12 a a DT cord-010119-t1x9gknd 4765 13 TG TG NNP cord-010119-t1x9gknd 4765 14 level level NN cord-010119-t1x9gknd 4765 15 of of IN cord-010119-t1x9gknd 4765 16 4980 4980 CD cord-010119-t1x9gknd 4765 17 mg mg NNP cord-010119-t1x9gknd 4765 18 / / SYM cord-010119-t1x9gknd 4765 19 dl dl NNP cord-010119-t1x9gknd 4765 20 , , , cord-010119-t1x9gknd 4765 21 lipase lipase NN cord-010119-t1x9gknd 4765 22 92 92 CD cord-010119-t1x9gknd 4765 23 U U NNP cord-010119-t1x9gknd 4765 24 / / SYM cord-010119-t1x9gknd 4765 25 L l NN cord-010119-t1x9gknd 4765 26 , , , cord-010119-t1x9gknd 4766 1 glucose glucose NN cord-010119-t1x9gknd 4766 2 250 250 CD cord-010119-t1x9gknd 4766 3 mg mg NNP cord-010119-t1x9gknd 4766 4 / / SYM cord-010119-t1x9gknd 4766 5 dl dl NN cord-010119-t1x9gknd 4766 6 , , , cord-010119-t1x9gknd 4766 7 Bicarbonate bicarbonate JJ cord-010119-t1x9gknd 4766 8 24 24 CD cord-010119-t1x9gknd 4766 9 mmol mmol NNP cord-010119-t1x9gknd 4766 10 / / SYM cord-010119-t1x9gknd 4766 11 L l NN cord-010119-t1x9gknd 4766 12 , , , cord-010119-t1x9gknd 4766 13 anion anion NN cord-010119-t1x9gknd 4766 14 gap gap NN cord-010119-t1x9gknd 4766 15 12 12 CD cord-010119-t1x9gknd 4766 16 . . . cord-010119-t1x9gknd 4767 1 CT CT NNP cord-010119-t1x9gknd 4767 2 findings finding NNS cord-010119-t1x9gknd 4767 3 were be VBD cord-010119-t1x9gknd 4767 4 consistent consistent JJ cord-010119-t1x9gknd 4767 5 with with IN cord-010119-t1x9gknd 4767 6 AP AP NNP cord-010119-t1x9gknd 4767 7 without without IN cord-010119-t1x9gknd 4767 8 evidence evidence NN cord-010119-t1x9gknd 4767 9 of of IN cord-010119-t1x9gknd 4767 10 necrosis necrosis NN cord-010119-t1x9gknd 4767 11 and and CC cord-010119-t1x9gknd 4767 12 stable stable JJ cord-010119-t1x9gknd 4767 13 pancreatic pancreatic JJ cord-010119-t1x9gknd 4767 14 pseudocyst pseudocyst NN cord-010119-t1x9gknd 4767 15 . . . cord-010119-t1x9gknd 4768 1 Medical medical JJ cord-010119-t1x9gknd 4768 2 therapy therapy NN cord-010119-t1x9gknd 4768 3 was be VBD cord-010119-t1x9gknd 4768 4 started start VBN cord-010119-t1x9gknd 4768 5 with with IN cord-010119-t1x9gknd 4768 6 Omega omega NN cord-010119-t1x9gknd 4768 7 3 3 CD cord-010119-t1x9gknd 4768 8 fatty fatty JJ cord-010119-t1x9gknd 4768 9 acid acid NN cord-010119-t1x9gknd 4768 10 , , , cord-010119-t1x9gknd 4768 11 fibrate fibrate JJ cord-010119-t1x9gknd 4768 12 , , , cord-010119-t1x9gknd 4768 13 statin statin NN cord-010119-t1x9gknd 4768 14 , , , cord-010119-t1x9gknd 4768 15 hydration hydration NN cord-010119-t1x9gknd 4768 16 as as RB cord-010119-t1x9gknd 4768 17 well well RB cord-010119-t1x9gknd 4768 18 as as IN cord-010119-t1x9gknd 4768 19 pain pain NN cord-010119-t1x9gknd 4768 20 control control NN cord-010119-t1x9gknd 4768 21 . . . cord-010119-t1x9gknd 4769 1 Statin statin NN cord-010119-t1x9gknd 4769 2 therapy therapy NN cord-010119-t1x9gknd 4769 3 was be VBD cord-010119-t1x9gknd 4769 4 suspended suspend VBN cord-010119-t1x9gknd 4769 5 on on IN cord-010119-t1x9gknd 4769 6 day day NN cord-010119-t1x9gknd 4769 7 3 3 CD cord-010119-t1x9gknd 4769 8 of of IN cord-010119-t1x9gknd 4769 9 hospitalization hospitalization NN cord-010119-t1x9gknd 4769 10 , , , cord-010119-t1x9gknd 4769 11 because because IN cord-010119-t1x9gknd 4769 12 he -PRON- PRP cord-010119-t1x9gknd 4769 13 was be VBD cord-010119-t1x9gknd 4769 14 noted note VBN cord-010119-t1x9gknd 4769 15 to to TO cord-010119-t1x9gknd 4769 16 have have VB cord-010119-t1x9gknd 4769 17 elevated elevate VBN cord-010119-t1x9gknd 4769 18 liver liver NN cord-010119-t1x9gknd 4769 19 function function NN cord-010119-t1x9gknd 4769 20 tests test NNS cord-010119-t1x9gknd 4769 21 ( ( -LRB- cord-010119-t1x9gknd 4769 22 LFT LFT NNP cord-010119-t1x9gknd 4769 23 ) ) -RRB- cord-010119-t1x9gknd 4769 24 and and CC cord-010119-t1x9gknd 4769 25 TPE TPE NNP cord-010119-t1x9gknd 4769 26 was be VBD cord-010119-t1x9gknd 4769 27 requested request VBN cord-010119-t1x9gknd 4769 28 and and CC cord-010119-t1x9gknd 4769 29 started start VBD cord-010119-t1x9gknd 4769 30 on on IN cord-010119-t1x9gknd 4769 31 day day NN cord-010119-t1x9gknd 4769 32 3 3 CD cord-010119-t1x9gknd 4769 33 after after IN cord-010119-t1x9gknd 4769 34 admission admission NN cord-010119-t1x9gknd 4769 35 . . . cord-010119-t1x9gknd 4770 1 Results/ Results/ . cord-010119-t1x9gknd 4771 1 Finding finding NN cord-010119-t1x9gknd 4771 2 : : : cord-010119-t1x9gknd 4772 1 The the DT cord-010119-t1x9gknd 4772 2 patient patient NN cord-010119-t1x9gknd 4772 3 TG TG NNP cord-010119-t1x9gknd 4772 4 decreased decrease VBD cord-010119-t1x9gknd 4772 5 by by IN cord-010119-t1x9gknd 4772 6 52 52 CD cord-010119-t1x9gknd 4772 7 % % NN cord-010119-t1x9gknd 4772 8 ( ( -LRB- cord-010119-t1x9gknd 4772 9 2365 2365 CD cord-010119-t1x9gknd 4772 10 mg mg NNP cord-010119-t1x9gknd 4772 11 / / SYM cord-010119-t1x9gknd 4772 12 dl dl NNP cord-010119-t1x9gknd 4772 13 ) ) -RRB- cord-010119-t1x9gknd 4772 14 with with IN cord-010119-t1x9gknd 4772 15 medical medical JJ cord-010119-t1x9gknd 4772 16 therapy therapy NN cord-010119-t1x9gknd 4772 17 , , , cord-010119-t1x9gknd 4772 18 followed follow VBN cord-010119-t1x9gknd 4772 19 by by IN cord-010119-t1x9gknd 4772 20 additional additional JJ cord-010119-t1x9gknd 4772 21 67 67 CD cord-010119-t1x9gknd 4772 22 % % NN cord-010119-t1x9gknd 4772 23 ( ( -LRB- cord-010119-t1x9gknd 4772 24 767 767 CD cord-010119-t1x9gknd 4772 25 mg mg NNP cord-010119-t1x9gknd 4772 26 / / SYM cord-010119-t1x9gknd 4772 27 dl dl NNP cord-010119-t1x9gknd 4772 28 ) ) -RRB- cord-010119-t1x9gknd 4772 29 after after IN cord-010119-t1x9gknd 4772 30 one one CD cord-010119-t1x9gknd 4772 31 volume volume NN cord-010119-t1x9gknd 4772 32 of of IN cord-010119-t1x9gknd 4772 33 TPE TPE NNP cord-010119-t1x9gknd 4772 34 . . . cord-010119-t1x9gknd 4773 1 His -PRON- PRP$ cord-010119-t1x9gknd 4773 2 symptoms symptom NNS cord-010119-t1x9gknd 4773 3 significantly significantly RB cord-010119-t1x9gknd 4773 4 improved improve VBD cord-010119-t1x9gknd 4773 5 and and CC cord-010119-t1x9gknd 4773 6 was be VBD cord-010119-t1x9gknd 4773 7 discharged discharge VBN cord-010119-t1x9gknd 4773 8 with with IN cord-010119-t1x9gknd 4773 9 medical medical JJ cord-010119-t1x9gknd 4773 10 treatment treatment NN cord-010119-t1x9gknd 4773 11 on on IN cord-010119-t1x9gknd 4773 12 day day NN cord-010119-t1x9gknd 4773 13 6 6 CD cord-010119-t1x9gknd 4773 14 after after IN cord-010119-t1x9gknd 4773 15 admission admission NN cord-010119-t1x9gknd 4773 16 . . . cord-010119-t1x9gknd 4774 1 Compared compare VBN cord-010119-t1x9gknd 4774 2 to to IN cord-010119-t1x9gknd 4774 3 previous previous JJ cord-010119-t1x9gknd 4774 4 episodes episode NNS cord-010119-t1x9gknd 4774 5 , , , cord-010119-t1x9gknd 4774 6 his -PRON- PRP$ cord-010119-t1x9gknd 4774 7 hospital hospital NN cord-010119-t1x9gknd 4774 8 stay stay NN cord-010119-t1x9gknd 4774 9 was be VBD cord-010119-t1x9gknd 4774 10 significantly significantly RB cord-010119-t1x9gknd 4774 11 decreased decrease VBN cord-010119-t1x9gknd 4774 12 . . . cord-010119-t1x9gknd 4775 1 TG TG NNP cord-010119-t1x9gknd 4775 2 levels level NNS cord-010119-t1x9gknd 4775 3 remained remain VBD cord-010119-t1x9gknd 4775 4 below below IN cord-010119-t1x9gknd 4775 5 1000 1000 CD cord-010119-t1x9gknd 4775 6 mg mg NNP cord-010119-t1x9gknd 4775 7 / / SYM cord-010119-t1x9gknd 4775 8 dl dl NN cord-010119-t1x9gknd 4775 9 at at IN cord-010119-t1x9gknd 4775 10 20 20 CD cord-010119-t1x9gknd 4775 11 days day NNS cord-010119-t1x9gknd 4775 12 follow follow VBP cord-010119-t1x9gknd 4775 13 up up RP cord-010119-t1x9gknd 4775 14 after after IN cord-010119-t1x9gknd 4775 15 discharge discharge NN cord-010119-t1x9gknd 4775 16 . . . cord-010119-t1x9gknd 4776 1 Conclusion conclusion NN cord-010119-t1x9gknd 4776 2 : : : cord-010119-t1x9gknd 4776 3 Early early JJ cord-010119-t1x9gknd 4776 4 TPE TPE NNP cord-010119-t1x9gknd 4776 5 may may MD cord-010119-t1x9gknd 4776 6 be be VB cord-010119-t1x9gknd 4776 7 of of IN cord-010119-t1x9gknd 4776 8 value value NN cord-010119-t1x9gknd 4776 9 in in IN cord-010119-t1x9gknd 4776 10 treating treat VBG cord-010119-t1x9gknd 4776 11 patients patient NNS cord-010119-t1x9gknd 4776 12 with with IN cord-010119-t1x9gknd 4776 13 elevated elevated JJ cord-010119-t1x9gknd 4776 14 TG TG NNP cord-010119-t1x9gknd 4776 15 associated associate VBN cord-010119-t1x9gknd 4776 16 with with IN cord-010119-t1x9gknd 4776 17 recurrent recurrent JJ cord-010119-t1x9gknd 4776 18 pancreatitis pancreatitis NN cord-010119-t1x9gknd 4776 19 . . . cord-010119-t1x9gknd 4777 1 Plasmapheresis Plasmapheresis NNP cord-010119-t1x9gknd 4777 2 might may MD cord-010119-t1x9gknd 4777 3 be be VB cord-010119-t1x9gknd 4777 4 an an DT cord-010119-t1x9gknd 4777 5 effective effective JJ cord-010119-t1x9gknd 4777 6 early early JJ cord-010119-t1x9gknd 4777 7 adjuvant adjuvant NN cord-010119-t1x9gknd 4777 8 therapy therapy NN cord-010119-t1x9gknd 4777 9 to to TO cord-010119-t1x9gknd 4777 10 mitigate mitigate VB cord-010119-t1x9gknd 4777 11 length length NN cord-010119-t1x9gknd 4777 12 of of IN cord-010119-t1x9gknd 4777 13 hospital hospital NN cord-010119-t1x9gknd 4777 14 stay stay NN cord-010119-t1x9gknd 4777 15 , , , cord-010119-t1x9gknd 4777 16 improve improve VB cord-010119-t1x9gknd 4777 17 cost cost NN cord-010119-t1x9gknd 4777 18 - - HYPH cord-010119-t1x9gknd 4777 19 effectiveness effectiveness NN cord-010119-t1x9gknd 4777 20 and and CC cord-010119-t1x9gknd 4777 21 patient patient JJ cord-010119-t1x9gknd 4777 22 safety safety NN cord-010119-t1x9gknd 4777 23 . . . cord-010119-t1x9gknd 4778 1 Background Background NNP cord-010119-t1x9gknd 4778 2 / / SYM cord-010119-t1x9gknd 4778 3 Case Case NNP cord-010119-t1x9gknd 4778 4 Studies Studies NNPS cord-010119-t1x9gknd 4778 5 : : : cord-010119-t1x9gknd 4779 1 From from IN cord-010119-t1x9gknd 4779 2 2009 2009 CD cord-010119-t1x9gknd 4779 3 to to IN cord-010119-t1x9gknd 4779 4 2013 2013 CD cord-010119-t1x9gknd 4779 5 , , , cord-010119-t1x9gknd 4779 6 a a DT cord-010119-t1x9gknd 4779 7 national national JJ cord-010119-t1x9gknd 4779 8 blood blood NN cord-010119-t1x9gknd 4779 9 donor donor NN cord-010119-t1x9gknd 4779 10 center center NN cord-010119-t1x9gknd 4779 11 in in IN cord-010119-t1x9gknd 4779 12 Southeast Southeast NNP cord-010119-t1x9gknd 4779 13 Asia Asia NNP cord-010119-t1x9gknd 4779 14 conducted conduct VBD cord-010119-t1x9gknd 4779 15 a a DT cord-010119-t1x9gknd 4779 16 program program NN cord-010119-t1x9gknd 4779 17 to to TO cord-010119-t1x9gknd 4779 18 monitor monitor VB cord-010119-t1x9gknd 4779 19 the the DT cord-010119-t1x9gknd 4779 20 ferritin ferritin NN cord-010119-t1x9gknd 4779 21 levels level NNS cord-010119-t1x9gknd 4779 22 of of IN cord-010119-t1x9gknd 4779 23 platelet platelet NN cord-010119-t1x9gknd 4779 24 blood blood NN cord-010119-t1x9gknd 4779 25 donors donor NNS cord-010119-t1x9gknd 4779 26 . . . cord-010119-t1x9gknd 4780 1 The the DT cord-010119-t1x9gknd 4780 2 aim aim NN cord-010119-t1x9gknd 4780 3 of of IN cord-010119-t1x9gknd 4780 4 this this DT cord-010119-t1x9gknd 4780 5 study study NN cord-010119-t1x9gknd 4780 6 was be VBD cord-010119-t1x9gknd 4780 7 to to TO cord-010119-t1x9gknd 4780 8 explore explore VB cord-010119-t1x9gknd 4780 9 the the DT cord-010119-t1x9gknd 4780 10 trend trend NN cord-010119-t1x9gknd 4780 11 of of IN cord-010119-t1x9gknd 4780 12 changes change NNS cord-010119-t1x9gknd 4780 13 in in IN cord-010119-t1x9gknd 4780 14 ferritin ferritin NN cord-010119-t1x9gknd 4780 15 . . . cord-010119-t1x9gknd 4781 1 Study Study NNP cord-010119-t1x9gknd 4781 2 Design Design NNP cord-010119-t1x9gknd 4781 3 / / SYM cord-010119-t1x9gknd 4781 4 Method method NN cord-010119-t1x9gknd 4781 5 : : : cord-010119-t1x9gknd 4781 6 In in IN cord-010119-t1x9gknd 4781 7 this this DT cord-010119-t1x9gknd 4781 8 study study NN cord-010119-t1x9gknd 4781 9 , , , cord-010119-t1x9gknd 4781 10 we -PRON- PRP cord-010119-t1x9gknd 4781 11 collected collect VBD cord-010119-t1x9gknd 4781 12 5,129 5,129 CD cord-010119-t1x9gknd 4781 13 cases case NNS cord-010119-t1x9gknd 4781 14 whose whose WP$ cord-010119-t1x9gknd 4781 15 ferritin ferritin NN cord-010119-t1x9gknd 4781 16 levels level NNS cord-010119-t1x9gknd 4781 17 have have VBP cord-010119-t1x9gknd 4781 18 been be VBN cord-010119-t1x9gknd 4781 19 monitored monitor VBN cord-010119-t1x9gknd 4781 20 more more JJR cord-010119-t1x9gknd 4781 21 than than IN cord-010119-t1x9gknd 4781 22 twice twice RB cord-010119-t1x9gknd 4781 23 with with IN cord-010119-t1x9gknd 4781 24 an an DT cord-010119-t1x9gknd 4781 25 interval interval NN cord-010119-t1x9gknd 4781 26 of of IN cord-010119-t1x9gknd 4781 27 detection detection NN cord-010119-t1x9gknd 4781 28 in in IN cord-010119-t1x9gknd 4781 29 150 150 CD cord-010119-t1x9gknd 4781 30 - - SYM cord-010119-t1x9gknd 4781 31 160 160 CD cord-010119-t1x9gknd 4781 32 days day NNS cord-010119-t1x9gknd 4781 33 . . . cord-010119-t1x9gknd 4782 1 The the DT cord-010119-t1x9gknd 4782 2 collected collect VBN cord-010119-t1x9gknd 4782 3 plasma plasma NN cord-010119-t1x9gknd 4782 4 samples sample NNS cord-010119-t1x9gknd 4782 5 were be VBD cord-010119-t1x9gknd 4782 6 tested test VBN cord-010119-t1x9gknd 4782 7 for for IN cord-010119-t1x9gknd 4782 8 ferritin ferritin NN cord-010119-t1x9gknd 4782 9 by by IN cord-010119-t1x9gknd 4782 10 chemiluminescence chemiluminescence NN cord-010119-t1x9gknd 4782 11 using use VBG cord-010119-t1x9gknd 4782 12 a a DT cord-010119-t1x9gknd 4782 13 commercial commercial JJ cord-010119-t1x9gknd 4782 14 assay assay NN cord-010119-t1x9gknd 4782 15 . . . cord-010119-t1x9gknd 4783 1 Inclusion inclusion NN cord-010119-t1x9gknd 4783 2 criteria criterion NNS cord-010119-t1x9gknd 4783 3 included include VBD cord-010119-t1x9gknd 4783 4 apheresis apheresis NN cord-010119-t1x9gknd 4783 5 platelet platelet NN cord-010119-t1x9gknd 4783 6 blood blood NN cord-010119-t1x9gknd 4783 7 donors donor NNS cord-010119-t1x9gknd 4783 8 with with IN cord-010119-t1x9gknd 4783 9 over over IN cord-010119-t1x9gknd 4783 10 two two CD cord-010119-t1x9gknd 4783 11 results result NNS cord-010119-t1x9gknd 4783 12 of of IN cord-010119-t1x9gknd 4783 13 ferritin ferritin NN cord-010119-t1x9gknd 4783 14 , , , cord-010119-t1x9gknd 4783 15 and and CC cord-010119-t1x9gknd 4783 16 first first JJ cord-010119-t1x9gknd 4783 17 time time NN cord-010119-t1x9gknd 4783 18 ferritin ferritin NN cord-010119-t1x9gknd 4783 19 test test NN cord-010119-t1x9gknd 4783 20 result result NN cord-010119-t1x9gknd 4783 21 was be VBD cord-010119-t1x9gknd 4783 22 over over IN cord-010119-t1x9gknd 4783 23 50 50 CD cord-010119-t1x9gknd 4783 24 lg lg NNP cord-010119-t1x9gknd 4783 25 / / SYM cord-010119-t1x9gknd 4783 26 L. L. NNP cord-010119-t1x9gknd 4784 1 And and CC cord-010119-t1x9gknd 4784 2 the the DT cord-010119-t1x9gknd 4784 3 upper upper JJ cord-010119-t1x9gknd 4784 4 limit limit NN cord-010119-t1x9gknd 4784 5 was be VBD cord-010119-t1x9gknd 4784 6 set set VBN cord-010119-t1x9gknd 4784 7 to to TO cord-010119-t1x9gknd 4784 8 be be VB cord-010119-t1x9gknd 4784 9 244 244 CD cord-010119-t1x9gknd 4784 10 lg/ lg/ NN cord-010119-t1x9gknd 4784 11 L l NN cord-010119-t1x9gknd 4784 12 in in IN cord-010119-t1x9gknd 4784 13 male male NN cord-010119-t1x9gknd 4784 14 and and CC cord-010119-t1x9gknd 4784 15 158 158 CD cord-010119-t1x9gknd 4784 16 lg lg NNP cord-010119-t1x9gknd 4784 17 / / SYM cord-010119-t1x9gknd 4784 18 L L NNP cord-010119-t1x9gknd 4784 19 in in IN cord-010119-t1x9gknd 4784 20 female female NN cord-010119-t1x9gknd 4784 21 as as IN cord-010119-t1x9gknd 4784 22 described describe VBN cord-010119-t1x9gknd 4784 23 in in IN cord-010119-t1x9gknd 4784 24 manufactures manufacture NNS cord-010119-t1x9gknd 4784 25 insert insert VBP cord-010119-t1x9gknd 4784 26 . . . cord-010119-t1x9gknd 4785 1 The the DT cord-010119-t1x9gknd 4785 2 impact impact NN cord-010119-t1x9gknd 4785 3 on on IN cord-010119-t1x9gknd 4785 4 ferritin ferritin NN cord-010119-t1x9gknd 4785 5 from from IN cord-010119-t1x9gknd 4785 6 gender gender NN cord-010119-t1x9gknd 4785 7 , , , cord-010119-t1x9gknd 4785 8 age age NN cord-010119-t1x9gknd 4785 9 , , , cord-010119-t1x9gknd 4785 10 and and CC cord-010119-t1x9gknd 4785 11 the the DT cord-010119-t1x9gknd 4785 12 blood blood NN cord-010119-t1x9gknd 4785 13 donation donation NN cord-010119-t1x9gknd 4785 14 frequency frequency NN cord-010119-t1x9gknd 4785 15 were be VBD cord-010119-t1x9gknd 4785 16 examined examine VBN cord-010119-t1x9gknd 4785 17 with with IN cord-010119-t1x9gknd 4785 18 ANOVA ANOVA NNP cord-010119-t1x9gknd 4785 19 test test NN cord-010119-t1x9gknd 4785 20 . . . cord-010119-t1x9gknd 4786 1 The the DT cord-010119-t1x9gknd 4786 2 blood blood NN cord-010119-t1x9gknd 4786 3 donations donation NNS cord-010119-t1x9gknd 4786 4 frequency frequency NN cord-010119-t1x9gknd 4786 5 was be VBD cord-010119-t1x9gknd 4786 6 categorized categorize VBN cord-010119-t1x9gknd 4786 7 into into IN cord-010119-t1x9gknd 4786 8 five five CD cord-010119-t1x9gknd 4786 9 groups group NNS cord-010119-t1x9gknd 4786 10 : : : cord-010119-t1x9gknd 4786 11 0 0 CD cord-010119-t1x9gknd 4786 12 times time NNS cord-010119-t1x9gknd 4786 13 , , , cord-010119-t1x9gknd 4786 14 1 1 CD cord-010119-t1x9gknd 4786 15 to to IN cord-010119-t1x9gknd 4786 16 3 3 CD cord-010119-t1x9gknd 4786 17 times time NNS cord-010119-t1x9gknd 4786 18 , , , cord-010119-t1x9gknd 4786 19 4 4 CD cord-010119-t1x9gknd 4786 20 to to TO cord-010119-t1x9gknd 4786 21 6 6 CD cord-010119-t1x9gknd 4786 22 times time NNS cord-010119-t1x9gknd 4786 23 , , , cord-010119-t1x9gknd 4786 24 7 7 CD cord-010119-t1x9gknd 4786 25 to to TO cord-010119-t1x9gknd 4786 26 9 9 CD cord-010119-t1x9gknd 4786 27 times time NNS cord-010119-t1x9gknd 4786 28 and and CC cord-010119-t1x9gknd 4786 29 more more JJR cord-010119-t1x9gknd 4786 30 than than IN cord-010119-t1x9gknd 4786 31 10 10 CD cord-010119-t1x9gknd 4786 32 times time NNS cord-010119-t1x9gknd 4786 33 . . . cord-010119-t1x9gknd 4787 1 The the DT cord-010119-t1x9gknd 4787 2 high high JJ cord-010119-t1x9gknd 4787 3 frequency frequency NN cord-010119-t1x9gknd 4787 4 ( ( -LRB- cord-010119-t1x9gknd 4787 5 more more JJR cord-010119-t1x9gknd 4787 6 than than IN cord-010119-t1x9gknd 4787 7 10 10 CD cord-010119-t1x9gknd 4787 8 times time NNS cord-010119-t1x9gknd 4787 9 group group NN cord-010119-t1x9gknd 4787 10 ) ) -RRB- cord-010119-t1x9gknd 4787 11 blood blood NN cord-010119-t1x9gknd 4787 12 donors donor NNS cord-010119-t1x9gknd 4787 13 were be VBD cord-010119-t1x9gknd 4787 14 analyzed analyze VBN cord-010119-t1x9gknd 4787 15 ferritin ferritin NN cord-010119-t1x9gknd 4787 16 changes change NNS cord-010119-t1x9gknd 4787 17 in in IN cord-010119-t1x9gknd 4787 18 longitudinal longitudinal JJ cord-010119-t1x9gknd 4787 19 data datum NNS cord-010119-t1x9gknd 4787 20 . . . cord-010119-t1x9gknd 4788 1 Results/ Results/ . cord-010119-t1x9gknd 4789 1 Finding find VBG cord-010119-t1x9gknd 4790 1 : : : cord-010119-t1x9gknd 4790 2 There there EX cord-010119-t1x9gknd 4790 3 were be VBD cord-010119-t1x9gknd 4790 4 5,129 5,129 CD cord-010119-t1x9gknd 4790 5 donors donor NNS cord-010119-t1x9gknd 4790 6 included include VBN cord-010119-t1x9gknd 4790 7 in in IN cord-010119-t1x9gknd 4790 8 the the DT cord-010119-t1x9gknd 4790 9 study study NN cord-010119-t1x9gknd 4790 10 , , , cord-010119-t1x9gknd 4790 11 of of IN cord-010119-t1x9gknd 4790 12 which which WDT cord-010119-t1x9gknd 4790 13 4,944 4,944 CD cord-010119-t1x9gknd 4790 14 were be VBD cord-010119-t1x9gknd 4790 15 male male JJ cord-010119-t1x9gknd 4790 16 ( ( -LRB- cord-010119-t1x9gknd 4790 17 96.4 96.4 CD cord-010119-t1x9gknd 4790 18 % % NN cord-010119-t1x9gknd 4790 19 ) ) -RRB- cord-010119-t1x9gknd 4790 20 and and CC cord-010119-t1x9gknd 4790 21 185 185 CD cord-010119-t1x9gknd 4790 22 were be VBD cord-010119-t1x9gknd 4790 23 female female JJ cord-010119-t1x9gknd 4790 24 ( ( -LRB- cord-010119-t1x9gknd 4790 25 3.6 3.6 CD cord-010119-t1x9gknd 4790 26 % % NN cord-010119-t1x9gknd 4790 27 ) ) -RRB- cord-010119-t1x9gknd 4790 28 . . . cord-010119-t1x9gknd 4791 1 The the DT cord-010119-t1x9gknd 4791 2 mean mean JJ cord-010119-t1x9gknd 4791 3 ferritin ferritin NN cord-010119-t1x9gknd 4791 4 was be VBD cord-010119-t1x9gknd 4791 5 82.0 82.0 CD cord-010119-t1x9gknd 4791 6 lg lg NNP cord-010119-t1x9gknd 4791 7 / / SYM cord-010119-t1x9gknd 4791 8 L L NNP cord-010119-t1x9gknd 4791 9 in in IN cord-010119-t1x9gknd 4791 10 male male NN cord-010119-t1x9gknd 4792 1 ( ( -LRB- cord-010119-t1x9gknd 4792 2 95 95 CD cord-010119-t1x9gknd 4792 3 % % NN cord-010119-t1x9gknd 4792 4 CI ci NN cord-010119-t1x9gknd 4792 5 : : : cord-010119-t1x9gknd 4792 6 80.7 80.7 CD cord-010119-t1x9gknd 4792 7 - - HYPH cord-010119-t1x9gknd 4792 8 83.2 83.2 CD cord-010119-t1x9gknd 4792 9 lg lg NNP cord-010119-t1x9gknd 4792 10 / / SYM cord-010119-t1x9gknd 4792 11 L L NNP cord-010119-t1x9gknd 4792 12 ) ) -RRB- cord-010119-t1x9gknd 4792 13 and and CC cord-010119-t1x9gknd 4792 14 66.5 66.5 CD cord-010119-t1x9gknd 4792 15 lg lg NNP cord-010119-t1x9gknd 4792 16 / / SYM cord-010119-t1x9gknd 4792 17 L L NNP cord-010119-t1x9gknd 4792 18 in in IN cord-010119-t1x9gknd 4792 19 female female JJ cord-010119-t1x9gknd 4792 20 ( ( -LRB- cord-010119-t1x9gknd 4792 21 95 95 CD cord-010119-t1x9gknd 4792 22 % % NN cord-010119-t1x9gknd 4792 23 CI ci NN cord-010119-t1x9gknd 4792 24 : : : cord-010119-t1x9gknd 4792 25 60.9 60.9 CD cord-010119-t1x9gknd 4792 26 - - HYPH cord-010119-t1x9gknd 4792 27 72.0 72.0 CD cord-010119-t1x9gknd 4792 28 lg lg NNP cord-010119-t1x9gknd 4792 29 / / SYM cord-010119-t1x9gknd 4792 30 L L NNP cord-010119-t1x9gknd 4792 31 ) ) -RRB- cord-010119-t1x9gknd 4792 32 . . . cord-010119-t1x9gknd 4793 1 The the DT cord-010119-t1x9gknd 4793 2 result result NN cord-010119-t1x9gknd 4793 3 of of IN cord-010119-t1x9gknd 4793 4 ANOVA ANOVA NNP cord-010119-t1x9gknd 4793 5 indicates indicate VBZ cord-010119-t1x9gknd 4793 6 that that IN cord-010119-t1x9gknd 4793 7 the the DT cord-010119-t1x9gknd 4793 8 group group NN cord-010119-t1x9gknd 4793 9 with with IN cord-010119-t1x9gknd 4793 10 the the DT cord-010119-t1x9gknd 4793 11 highest high JJS cord-010119-t1x9gknd 4793 12 frequency frequency NN cord-010119-t1x9gknd 4793 13 ( ( -LRB- cord-010119-t1x9gknd 4793 14 more more JJR cord-010119-t1x9gknd 4793 15 than than IN cord-010119-t1x9gknd 4793 16 10 10 CD cord-010119-t1x9gknd 4793 17 times time NNS cord-010119-t1x9gknd 4793 18 ) ) -RRB- cord-010119-t1x9gknd 4793 19 has have VBZ cord-010119-t1x9gknd 4793 20 the the DT cord-010119-t1x9gknd 4793 21 significant significant JJ cord-010119-t1x9gknd 4793 22 lowest low JJS cord-010119-t1x9gknd 4793 23 ferritin ferritin NN cord-010119-t1x9gknd 4793 24 level level NN cord-010119-t1x9gknd 4793 25 ( ( -LRB- cord-010119-t1x9gknd 4793 26 p<0.05 p<0.05 CD cord-010119-t1x9gknd 4793 27 ) ) -RRB- cord-010119-t1x9gknd 4793 28 . . . cord-010119-t1x9gknd 4794 1 The the DT cord-010119-t1x9gknd 4794 2 average average JJ cord-010119-t1x9gknd 4794 3 change change NN cord-010119-t1x9gknd 4794 4 of of IN cord-010119-t1x9gknd 4794 5 ferritin ferritin NN cord-010119-t1x9gknd 4794 6 if if IN cord-010119-t1x9gknd 4794 7 donation donation NN cord-010119-t1x9gknd 4794 8 over over IN cord-010119-t1x9gknd 4794 9 10 10 CD cord-010119-t1x9gknd 4794 10 times time NNS cord-010119-t1x9gknd 4794 11 would would MD cord-010119-t1x9gknd 4794 12 up up IN cord-010119-t1x9gknd 4794 13 to to TO cord-010119-t1x9gknd 4794 14 13.4 13.4 CD cord-010119-t1x9gknd 4794 15 and and CC cord-010119-t1x9gknd 4794 16 14.1 14.1 CD cord-010119-t1x9gknd 4794 17 lg lg NNP cord-010119-t1x9gknd 4794 18 / / SYM cord-010119-t1x9gknd 4794 19 L L NNP cord-010119-t1x9gknd 4794 20 in in IN cord-010119-t1x9gknd 4794 21 younger young JJR cord-010119-t1x9gknd 4794 22 and and CC cord-010119-t1x9gknd 4794 23 elder eld JJR cord-010119-t1x9gknd 4794 24 50 50 CD cord-010119-t1x9gknd 4794 25 y y NN cord-010119-t1x9gknd 4794 26 / / SYM cord-010119-t1x9gknd 4794 27 o o NN cord-010119-t1x9gknd 4794 28 male male NN cord-010119-t1x9gknd 4794 29 and and CC cord-010119-t1x9gknd 4794 30 18 18 CD cord-010119-t1x9gknd 4794 31 and and CC cord-010119-t1x9gknd 4794 32 23 23 CD cord-010119-t1x9gknd 4794 33 lg lg NNP cord-010119-t1x9gknd 4794 34 / / SYM cord-010119-t1x9gknd 4794 35 L L NNP cord-010119-t1x9gknd 4794 36 in in IN cord-010119-t1x9gknd 4794 37 female female NN cord-010119-t1x9gknd 4794 38 . . . cord-010119-t1x9gknd 4795 1 And and CC cord-010119-t1x9gknd 4795 2 then then RB cord-010119-t1x9gknd 4795 3 for for IN cord-010119-t1x9gknd 4795 4 high high JJ cord-010119-t1x9gknd 4795 5 frequency frequency NN cord-010119-t1x9gknd 4795 6 ( ( -LRB- cord-010119-t1x9gknd 4795 7 half half PDT cord-010119-t1x9gknd 4795 8 a a DT cord-010119-t1x9gknd 4795 9 year year NN cord-010119-t1x9gknd 4795 10 more more JJR cord-010119-t1x9gknd 4795 11 than than IN cord-010119-t1x9gknd 4795 12 10 10 CD cord-010119-t1x9gknd 4795 13 times time NNS cord-010119-t1x9gknd 4795 14 the the DT cord-010119-t1x9gknd 4795 15 group group NN cord-010119-t1x9gknd 4795 16 of of IN cord-010119-t1x9gknd 4795 17 blood blood NN cord-010119-t1x9gknd 4795 18 donors donor NNS cord-010119-t1x9gknd 4795 19 ) ) -RRB- cord-010119-t1x9gknd 4795 20 for for IN cord-010119-t1x9gknd 4795 21 longitudinal longitudinal JJ cord-010119-t1x9gknd 4795 22 analysis analysis NN cord-010119-t1x9gknd 4795 23 and and CC cord-010119-t1x9gknd 4795 24 found find VBD cord-010119-t1x9gknd 4795 25 that that IN cord-010119-t1x9gknd 4795 26 the the DT cord-010119-t1x9gknd 4795 27 long long JJ cord-010119-t1x9gknd 4795 28 - - HYPH cord-010119-t1x9gknd 4795 29 term term NN cord-010119-t1x9gknd 4795 30 sustained sustain VBD cord-010119-t1x9gknd 4795 31 high high JJ cord-010119-t1x9gknd 4795 32 frequency frequency NN cord-010119-t1x9gknd 4795 33 of of IN cord-010119-t1x9gknd 4795 34 blood blood NN cord-010119-t1x9gknd 4795 35 donation donation NN cord-010119-t1x9gknd 4795 36 caused cause VBD cord-010119-t1x9gknd 4795 37 a a DT cord-010119-t1x9gknd 4795 38 significant significant JJ cord-010119-t1x9gknd 4795 39 decline decline NN cord-010119-t1x9gknd 4795 40 in in IN cord-010119-t1x9gknd 4795 41 ferritin ferritin NN cord-010119-t1x9gknd 4795 42 . . . cord-010119-t1x9gknd 4796 1 The the DT cord-010119-t1x9gknd 4796 2 average average JJ cord-010119-t1x9gknd 4796 3 change change NN cord-010119-t1x9gknd 4796 4 about about IN cord-010119-t1x9gknd 4796 5 ferritin ferritin NN cord-010119-t1x9gknd 4796 6 in in IN cord-010119-t1x9gknd 4796 7 high high JJ cord-010119-t1x9gknd 4796 8 frequencies frequency NNS cord-010119-t1x9gknd 4796 9 donors donor NNS cord-010119-t1x9gknd 4796 10 ( ( -LRB- cord-010119-t1x9gknd 4796 11 over over IN cord-010119-t1x9gknd 4796 12 10 10 CD cord-010119-t1x9gknd 4796 13 times time NNS cord-010119-t1x9gknd 4796 14 in in IN cord-010119-t1x9gknd 4796 15 150$160 150$160 CD cord-010119-t1x9gknd 4796 16 days day NNS cord-010119-t1x9gknd 4796 17 ) ) -RRB- cord-010119-t1x9gknd 4796 18 was be VBD cord-010119-t1x9gknd 4796 19 reduced reduce VBN cord-010119-t1x9gknd 4796 20 from from IN cord-010119-t1x9gknd 4796 21 21.5 21.5 CD cord-010119-t1x9gknd 4796 22 lg lg NNP cord-010119-t1x9gknd 4796 23 / / SYM cord-010119-t1x9gknd 4796 24 L L NNP cord-010119-t1x9gknd 4796 25 in in IN cord-010119-t1x9gknd 4796 26 the the DT cord-010119-t1x9gknd 4796 27 first first JJ cord-010119-t1x9gknd 4796 28 period period NN cord-010119-t1x9gknd 4796 29 to to IN cord-010119-t1x9gknd 4796 30 4.1 4.1 CD cord-010119-t1x9gknd 4796 31 lg lg NNP cord-010119-t1x9gknd 4796 32 / / SYM cord-010119-t1x9gknd 4796 33 L L NNP cord-010119-t1x9gknd 4796 34 in in IN cord-010119-t1x9gknd 4796 35 the the DT cord-010119-t1x9gknd 4796 36 third third JJ cord-010119-t1x9gknd 4796 37 period period NN cord-010119-t1x9gknd 4796 38 ( ( -LRB- cord-010119-t1x9gknd 4796 39 1 1 CD cord-010119-t1x9gknd 4796 40 period5150$160 period5150$160 JJ cord-010119-t1x9gknd 4796 41 days day NNS cord-010119-t1x9gknd 4796 42 ) ) -RRB- cord-010119-t1x9gknd 4796 43 . . . cord-010119-t1x9gknd 4797 1 Along along IN cord-010119-t1x9gknd 4797 2 with with IN cord-010119-t1x9gknd 4797 3 the the DT cord-010119-t1x9gknd 4797 4 more more JJR cord-010119-t1x9gknd 4797 5 and and CC cord-010119-t1x9gknd 4797 6 more more JJR cord-010119-t1x9gknd 4797 7 period period NN cord-010119-t1x9gknd 4797 8 , , , cord-010119-t1x9gknd 4797 9 the the DT cord-010119-t1x9gknd 4797 10 decline decline NN cord-010119-t1x9gknd 4797 11 of of IN cord-010119-t1x9gknd 4797 12 ferritin ferritin NN cord-010119-t1x9gknd 4797 13 decreased decrease VBD cord-010119-t1x9gknd 4797 14 . . . cord-010119-t1x9gknd 4798 1 Conclusion conclusion NN cord-010119-t1x9gknd 4798 2 : : : cord-010119-t1x9gknd 4799 1 This this DT cord-010119-t1x9gknd 4799 2 analysis analysis NN cord-010119-t1x9gknd 4799 3 revealed reveal VBD cord-010119-t1x9gknd 4799 4 that that IN cord-010119-t1x9gknd 4799 5 frequent frequent JJ cord-010119-t1x9gknd 4799 6 apheresis apheresis NN cord-010119-t1x9gknd 4799 7 platelet platelet NN cord-010119-t1x9gknd 4799 8 donation donation NN cord-010119-t1x9gknd 4799 9 would would MD cord-010119-t1x9gknd 4799 10 decrease decrease VB cord-010119-t1x9gknd 4799 11 ferritin ferritin NN cord-010119-t1x9gknd 4799 12 of of IN cord-010119-t1x9gknd 4799 13 donors donor NNS cord-010119-t1x9gknd 4799 14 . . . cord-010119-t1x9gknd 4800 1 But but CC cord-010119-t1x9gknd 4800 2 the the DT cord-010119-t1x9gknd 4800 3 high high JJ cord-010119-t1x9gknd 4800 4 frequency frequency NN cord-010119-t1x9gknd 4800 5 of of IN cord-010119-t1x9gknd 4800 6 platelet platelet NN cord-010119-t1x9gknd 4800 7 blood blood NN cord-010119-t1x9gknd 4800 8 donors donor NNS cord-010119-t1x9gknd 4800 9 who who WP cord-010119-t1x9gknd 4800 10 continue continue VBP cord-010119-t1x9gknd 4800 11 to to TO cord-010119-t1x9gknd 4800 12 donate donate VB cord-010119-t1x9gknd 4800 13 after after IN cord-010119-t1x9gknd 4800 14 a a DT cord-010119-t1x9gknd 4800 15 year year NN cord-010119-t1x9gknd 4800 16 , , , cord-010119-t1x9gknd 4800 17 the the DT cord-010119-t1x9gknd 4800 18 decline decline NN cord-010119-t1x9gknd 4800 19 of of IN cord-010119-t1x9gknd 4800 20 ferritin ferritin NN cord-010119-t1x9gknd 4800 21 slowed slow VBD cord-010119-t1x9gknd 4800 22 down down RP cord-010119-t1x9gknd 4800 23 . . . cord-010119-t1x9gknd 4801 1 A a DT cord-010119-t1x9gknd 4801 2 Rare Rare NNP cord-010119-t1x9gknd 4801 3 Case case NN cord-010119-t1x9gknd 4801 4 of of IN cord-010119-t1x9gknd 4801 5 Blood Blood NNP cord-010119-t1x9gknd 4801 6 Donation Donation NNP cord-010119-t1x9gknd 4801 7 Precipitating Precipitating NNP cord-010119-t1x9gknd 4801 8 Acute acute JJ cord-010119-t1x9gknd 4801 9 Delirium Delirium NNP cord-010119-t1x9gknd 4801 10 Joseph Joseph NNP cord-010119-t1x9gknd 4801 11 Griggs Griggs NNP cord-010119-t1x9gknd 4801 12 * * NFP cord-010119-t1x9gknd 4801 13 1 1 CD cord-010119-t1x9gknd 4801 14 , , , cord-010119-t1x9gknd 4801 15 Mary Mary NNP cord-010119-t1x9gknd 4801 16 Townsend Townsend NNP cord-010119-t1x9gknd 4801 17 2 2 CD cord-010119-t1x9gknd 4801 18 and and CC cord-010119-t1x9gknd 4801 19 Lizabeth Lizabeth NNP cord-010119-t1x9gknd 4801 20 Rosenbaum Rosenbaum NNP cord-010119-t1x9gknd 4802 1 3 3 LS cord-010119-t1x9gknd 4802 2 . . . cord-010119-t1x9gknd 4803 1 1 1 CD cord-010119-t1x9gknd 4803 2 University University NNP cord-010119-t1x9gknd 4803 3 Of of IN cord-010119-t1x9gknd 4803 4 New New NNP cord-010119-t1x9gknd 4803 5 Mexico Mexico NNP cord-010119-t1x9gknd 4803 6 Hospital Hospital NNP cord-010119-t1x9gknd 4803 7 , , , cord-010119-t1x9gknd 4803 8 2 2 CD cord-010119-t1x9gknd 4803 9 Blood Blood NNP cord-010119-t1x9gknd 4803 10 Systems Systems NNPS cord-010119-t1x9gknd 4803 11 , , , cord-010119-t1x9gknd 4803 12 Inc. Inc. NNP cord-010119-t1x9gknd 4803 13 , , , cord-010119-t1x9gknd 4804 1 3 3 LS cord-010119-t1x9gknd 4804 2 Blood Blood NNP cord-010119-t1x9gknd 4804 3 Systems Systems NNPS cord-010119-t1x9gknd 4804 4 Inc. Inc. NNP cord-010119-t1x9gknd 4804 5 Background Background NNP cord-010119-t1x9gknd 4804 6 / / SYM cord-010119-t1x9gknd 4804 7 Case Case NNP cord-010119-t1x9gknd 4804 8 Studies Studies NNPS cord-010119-t1x9gknd 4805 1 : : : cord-010119-t1x9gknd 4805 2 We -PRON- PRP cord-010119-t1x9gknd 4805 3 report report VBP cord-010119-t1x9gknd 4805 4 a a DT cord-010119-t1x9gknd 4805 5 case case NN cord-010119-t1x9gknd 4805 6 of of IN cord-010119-t1x9gknd 4805 7 whole whole JJ cord-010119-t1x9gknd 4805 8 blood blood NN cord-010119-t1x9gknd 4805 9 ( ( -LRB- cord-010119-t1x9gknd 4805 10 WB WB NNP cord-010119-t1x9gknd 4805 11 ) ) -RRB- cord-010119-t1x9gknd 4805 12 donation donation NN cord-010119-t1x9gknd 4805 13 that that WDT cord-010119-t1x9gknd 4805 14 precipitated precipitate VBD cord-010119-t1x9gknd 4805 15 a a DT cord-010119-t1x9gknd 4805 16 transient transient JJ cord-010119-t1x9gknd 4805 17 agitated agitate VBN cord-010119-t1x9gknd 4805 18 delirium delirium NN cord-010119-t1x9gknd 4805 19 . . . cord-010119-t1x9gknd 4806 1 A a DT cord-010119-t1x9gknd 4806 2 22 22 CD cord-010119-t1x9gknd 4806 3 year year NN cord-010119-t1x9gknd 4806 4 - - HYPH cord-010119-t1x9gknd 4806 5 old old JJ cord-010119-t1x9gknd 4806 6 first first JJ cord-010119-t1x9gknd 4806 7 time time NN cord-010119-t1x9gknd 4806 8 male male JJ cord-010119-t1x9gknd 4806 9 donor donor NN cord-010119-t1x9gknd 4806 10 presented present VBN cord-010119-t1x9gknd 4806 11 to to IN cord-010119-t1x9gknd 4806 12 the the DT cord-010119-t1x9gknd 4806 13 local local JJ cord-010119-t1x9gknd 4806 14 blood blood NN cord-010119-t1x9gknd 4806 15 center center NN cord-010119-t1x9gknd 4806 16 , , , cord-010119-t1x9gknd 4806 17 completed complete VBD cord-010119-t1x9gknd 4806 18 the the DT cord-010119-t1x9gknd 4806 19 donor donor NN cord-010119-t1x9gknd 4806 20 health health NN cord-010119-t1x9gknd 4806 21 questionnaire questionnaire NN cord-010119-t1x9gknd 4806 22 , , , cord-010119-t1x9gknd 4806 23 mini mini JJ cord-010119-t1x9gknd 4806 24 - - JJ cord-010119-t1x9gknd 4806 25 physical physical JJ cord-010119-t1x9gknd 4806 26 exam exam NN cord-010119-t1x9gknd 4806 27 , , , cord-010119-t1x9gknd 4806 28 and and CC cord-010119-t1x9gknd 4806 29 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4806 30 check check NN cord-010119-t1x9gknd 4806 31 , , , cord-010119-t1x9gknd 4806 32 and and CC cord-010119-t1x9gknd 4806 33 was be VBD cord-010119-t1x9gknd 4806 34 deemed deem VBN cord-010119-t1x9gknd 4806 35 eligible eligible JJ cord-010119-t1x9gknd 4806 36 for for IN cord-010119-t1x9gknd 4806 37 blood blood NN cord-010119-t1x9gknd 4806 38 donation donation NN cord-010119-t1x9gknd 4806 39 . . . cord-010119-t1x9gknd 4807 1 Approximately approximately RB cord-010119-t1x9gknd 4807 2 10 10 CD cord-010119-t1x9gknd 4807 3 minutes minute NNS cord-010119-t1x9gknd 4807 4 after after IN cord-010119-t1x9gknd 4807 5 an an DT cord-010119-t1x9gknd 4807 6 uncomplicated uncomplicated JJ cord-010119-t1x9gknd 4807 7 WB WB NNP cord-010119-t1x9gknd 4807 8 donation donation NN cord-010119-t1x9gknd 4807 9 , , , cord-010119-t1x9gknd 4807 10 the the DT cord-010119-t1x9gknd 4807 11 donor donor NN cord-010119-t1x9gknd 4807 12 had have VBD cord-010119-t1x9gknd 4807 13 an an DT cord-010119-t1x9gknd 4807 14 observed observed JJ cord-010119-t1x9gknd 4807 15 , , , cord-010119-t1x9gknd 4807 16 brief brief JJ cord-010119-t1x9gknd 4807 17 loss loss NN cord-010119-t1x9gknd 4807 18 of of IN cord-010119-t1x9gknd 4807 19 consciousness consciousness NN cord-010119-t1x9gknd 4807 20 in in IN cord-010119-t1x9gknd 4807 21 the the DT cord-010119-t1x9gknd 4807 22 post post JJ cord-010119-t1x9gknd 4807 23 - - JJ cord-010119-t1x9gknd 4807 24 donation donation JJ cord-010119-t1x9gknd 4807 25 area area NN cord-010119-t1x9gknd 4807 26 . . . cord-010119-t1x9gknd 4808 1 No no DT cord-010119-t1x9gknd 4808 2 fall fall NN cord-010119-t1x9gknd 4808 3 or or CC cord-010119-t1x9gknd 4808 4 injury injury NN cord-010119-t1x9gknd 4808 5 was be VBD cord-010119-t1x9gknd 4808 6 seen see VBN cord-010119-t1x9gknd 4808 7 . . . cord-010119-t1x9gknd 4809 1 Shortly shortly RB cord-010119-t1x9gknd 4809 2 after after IN cord-010119-t1x9gknd 4809 3 regaining regain VBG cord-010119-t1x9gknd 4809 4 consciousness consciousness NN cord-010119-t1x9gknd 4809 5 , , , cord-010119-t1x9gknd 4809 6 the the DT cord-010119-t1x9gknd 4809 7 donor donor NN cord-010119-t1x9gknd 4809 8 became become VBD cord-010119-t1x9gknd 4809 9 agitated agitated JJ cord-010119-t1x9gknd 4809 10 , , , cord-010119-t1x9gknd 4809 11 confused confused JJ cord-010119-t1x9gknd 4809 12 , , , cord-010119-t1x9gknd 4809 13 and and CC cord-010119-t1x9gknd 4809 14 was be VBD cord-010119-t1x9gknd 4809 15 not not RB cord-010119-t1x9gknd 4809 16 oriented orient VBN cord-010119-t1x9gknd 4809 17 to to IN cord-010119-t1x9gknd 4809 18 month month NN cord-010119-t1x9gknd 4809 19 or or CC cord-010119-t1x9gknd 4809 20 year year NN cord-010119-t1x9gknd 4809 21 ; ; : cord-010119-t1x9gknd 4809 22 was be VBD cord-010119-t1x9gknd 4809 23 unable unable JJ cord-010119-t1x9gknd 4809 24 to to TO cord-010119-t1x9gknd 4809 25 remember remember VB cord-010119-t1x9gknd 4809 26 the the DT cord-010119-t1x9gknd 4809 27 names name NNS cord-010119-t1x9gknd 4809 28 of of IN cord-010119-t1x9gknd 4809 29 friends friend NNS cord-010119-t1x9gknd 4809 30 and and CC cord-010119-t1x9gknd 4809 31 family family NN cord-010119-t1x9gknd 4809 32 members member NNS cord-010119-t1x9gknd 4809 33 ; ; , cord-010119-t1x9gknd 4809 34 was be VBD cord-010119-t1x9gknd 4809 35 unable unable JJ cord-010119-t1x9gknd 4809 36 to to TO cord-010119-t1x9gknd 4809 37 read read VB cord-010119-t1x9gknd 4809 38 an an DT cord-010119-t1x9gknd 4809 39 analog analog JJ cord-010119-t1x9gknd 4809 40 clock clock NN cord-010119-t1x9gknd 4809 41 ; ; : cord-010119-t1x9gknd 4809 42 and and CC cord-010119-t1x9gknd 4809 43 had have VBD cord-010119-t1x9gknd 4809 44 difficulty difficulty NN cord-010119-t1x9gknd 4809 45 with with IN cord-010119-t1x9gknd 4809 46 word word NN cord-010119-t1x9gknd 4809 47 finding finding NN cord-010119-t1x9gknd 4809 48 . . . cord-010119-t1x9gknd 4810 1 The the DT cord-010119-t1x9gknd 4810 2 donor donor NN cord-010119-t1x9gknd 4810 3 was be VBD cord-010119-t1x9gknd 4810 4 transported transport VBN cord-010119-t1x9gknd 4810 5 to to IN cord-010119-t1x9gknd 4810 6 the the DT cord-010119-t1x9gknd 4810 7 local local JJ cord-010119-t1x9gknd 4810 8 university university NN cord-010119-t1x9gknd 4810 9 hospital hospital NN cord-010119-t1x9gknd 4810 10 where where WRB cord-010119-t1x9gknd 4810 11 he -PRON- PRP cord-010119-t1x9gknd 4810 12 was be VBD cord-010119-t1x9gknd 4810 13 noted note VBN cord-010119-t1x9gknd 4810 14 to to TO cord-010119-t1x9gknd 4810 15 be be VB cord-010119-t1x9gknd 4810 16 combatively combatively RB cord-010119-t1x9gknd 4810 17 delirious delirious JJ cord-010119-t1x9gknd 4810 18 and and CC cord-010119-t1x9gknd 4810 19 had have VBD cord-010119-t1x9gknd 4810 20 altered alter VBN cord-010119-t1x9gknd 4810 21 mental mental JJ cord-010119-t1x9gknd 4810 22 status status NN cord-010119-t1x9gknd 4810 23 ; ; : cord-010119-t1x9gknd 4810 24 he -PRON- PRP cord-010119-t1x9gknd 4810 25 had have VBD cord-010119-t1x9gknd 4810 26 to to TO cord-010119-t1x9gknd 4810 27 be be VB cord-010119-t1x9gknd 4810 28 forcibly forcibly RB cord-010119-t1x9gknd 4810 29 restrained restrain VBN cord-010119-t1x9gknd 4810 30 . . . cord-010119-t1x9gknd 4811 1 He -PRON- PRP cord-010119-t1x9gknd 4811 2 ultimately ultimately RB cord-010119-t1x9gknd 4811 3 was be VBD cord-010119-t1x9gknd 4811 4 sedated sedate VBN cord-010119-t1x9gknd 4811 5 and and CC cord-010119-t1x9gknd 4811 6 intubated intubate VBN cord-010119-t1x9gknd 4811 7 , , , cord-010119-t1x9gknd 4811 8 and and CC cord-010119-t1x9gknd 4811 9 transferred transfer VBN cord-010119-t1x9gknd 4811 10 to to IN cord-010119-t1x9gknd 4811 11 the the DT cord-010119-t1x9gknd 4811 12 intensive intensive JJ cord-010119-t1x9gknd 4811 13 care care NN cord-010119-t1x9gknd 4811 14 unit unit NN cord-010119-t1x9gknd 4811 15 . . . cord-010119-t1x9gknd 4812 1 Study Study NNP cord-010119-t1x9gknd 4812 2 Design Design NNP cord-010119-t1x9gknd 4812 3 / / SYM cord-010119-t1x9gknd 4812 4 Method method NN cord-010119-t1x9gknd 4812 5 : : : cord-010119-t1x9gknd 4813 1 An an DT cord-010119-t1x9gknd 4813 2 extensive extensive JJ cord-010119-t1x9gknd 4813 3 laboratory laboratory NN cord-010119-t1x9gknd 4813 4 investigation investigation NN cord-010119-t1x9gknd 4813 5 was be VBD cord-010119-t1x9gknd 4813 6 performed perform VBN cord-010119-t1x9gknd 4813 7 including include VBG cord-010119-t1x9gknd 4813 8 standard standard JJ cord-010119-t1x9gknd 4813 9 hematologic hematologic NN cord-010119-t1x9gknd 4813 10 and and CC cord-010119-t1x9gknd 4813 11 chemistry chemistry NN cord-010119-t1x9gknd 4813 12 panels panel NNS cord-010119-t1x9gknd 4813 13 ; ; : cord-010119-t1x9gknd 4813 14 serologic serologic NNP cord-010119-t1x9gknd 4813 15 and and CC cord-010119-t1x9gknd 4813 16 PCR PCR NNP cord-010119-t1x9gknd 4813 17 - - HYPH cord-010119-t1x9gknd 4813 18 based base VBN cord-010119-t1x9gknd 4813 19 studies study NNS cord-010119-t1x9gknd 4813 20 for for IN cord-010119-t1x9gknd 4813 21 multiple multiple JJ cord-010119-t1x9gknd 4813 22 organisms organism NNS cord-010119-t1x9gknd 4813 23 including include VBG cord-010119-t1x9gknd 4813 24 West West NNP cord-010119-t1x9gknd 4813 25 Nile Nile NNP cord-010119-t1x9gknd 4813 26 , , , cord-010119-t1x9gknd 4813 27 herpes herpe NNS cord-010119-t1x9gknd 4813 28 , , , cord-010119-t1x9gknd 4813 29 HIV HIV NNP cord-010119-t1x9gknd 4813 30 , , , cord-010119-t1x9gknd 4813 31 varicella varicella NN cord-010119-t1x9gknd 4813 32 zoster zoster NN cord-010119-t1x9gknd 4813 33 , , , cord-010119-t1x9gknd 4813 34 and and CC cord-010119-t1x9gknd 4813 35 syphilis syphili NNS cord-010119-t1x9gknd 4813 36 ; ; , cord-010119-t1x9gknd 4813 37 aerobic aerobic JJ cord-010119-t1x9gknd 4813 38 and and CC cord-010119-t1x9gknd 4813 39 anaerobic anaerobic JJ cord-010119-t1x9gknd 4813 40 blood blood NN cord-010119-t1x9gknd 4813 41 cultures culture NNS cord-010119-t1x9gknd 4813 42 ; ; : cord-010119-t1x9gknd 4813 43 and and CC cord-010119-t1x9gknd 4813 44 a a DT cord-010119-t1x9gknd 4813 45 urine urine NN cord-010119-t1x9gknd 4813 46 drug drug NN cord-010119-t1x9gknd 4813 47 screen screen NN cord-010119-t1x9gknd 4813 48 for for IN cord-010119-t1x9gknd 4813 49 multiple multiple JJ cord-010119-t1x9gknd 4813 50 drugs drug NNS cord-010119-t1x9gknd 4813 51 of of IN cord-010119-t1x9gknd 4813 52 abuse abuse NN cord-010119-t1x9gknd 4813 53 . . . cord-010119-t1x9gknd 4814 1 Radiographic radiographic JJ cord-010119-t1x9gknd 4814 2 imaging imaging NN cord-010119-t1x9gknd 4814 3 was be VBD cord-010119-t1x9gknd 4814 4 performed perform VBN cord-010119-t1x9gknd 4814 5 including include VBG cord-010119-t1x9gknd 4814 6 a a DT cord-010119-t1x9gknd 4814 7 chest chest NN cord-010119-t1x9gknd 4814 8 x x NN cord-010119-t1x9gknd 4814 9 - - NN cord-010119-t1x9gknd 4814 10 ray ray NN cord-010119-t1x9gknd 4814 11 , , , cord-010119-t1x9gknd 4814 12 and and CC cord-010119-t1x9gknd 4814 13 a a DT cord-010119-t1x9gknd 4814 14 CT CT NNP cord-010119-t1x9gknd 4814 15 and and CC cord-010119-t1x9gknd 4814 16 MRI MRI NNP cord-010119-t1x9gknd 4814 17 of of IN cord-010119-t1x9gknd 4814 18 head head NN cord-010119-t1x9gknd 4814 19 and and CC cord-010119-t1x9gknd 4814 20 spine spine NN cord-010119-t1x9gknd 4814 21 . . . cord-010119-t1x9gknd 4815 1 In in IN cord-010119-t1x9gknd 4815 2 addition addition NN cord-010119-t1x9gknd 4815 3 , , , cord-010119-t1x9gknd 4815 4 an an DT cord-010119-t1x9gknd 4815 5 EEG EEG NNP cord-010119-t1x9gknd 4815 6 was be VBD cord-010119-t1x9gknd 4815 7 performed perform VBN cord-010119-t1x9gknd 4815 8 . . . cord-010119-t1x9gknd 4816 1 The the DT cord-010119-t1x9gknd 4816 2 inpatient inpatient JJ cord-010119-t1x9gknd 4816 3 neurology neurology NN cord-010119-t1x9gknd 4816 4 and and CC cord-010119-t1x9gknd 4816 5 psychiatry psychiatry NN cord-010119-t1x9gknd 4816 6 services service NNS cord-010119-t1x9gknd 4816 7 were be VBD cord-010119-t1x9gknd 4816 8 consulted consult VBN cord-010119-t1x9gknd 4816 9 for for IN cord-010119-t1x9gknd 4816 10 this this DT cord-010119-t1x9gknd 4816 11 patient patient NN cord-010119-t1x9gknd 4816 12 . . . cord-010119-t1x9gknd 4817 1 Results/ Results/ . cord-010119-t1x9gknd 4818 1 Finding finding NN cord-010119-t1x9gknd 4818 2 : : : cord-010119-t1x9gknd 4818 3 After after IN cord-010119-t1x9gknd 4818 4 the the DT cord-010119-t1x9gknd 4818 5 sedation sedation NN cord-010119-t1x9gknd 4818 6 was be VBD cord-010119-t1x9gknd 4818 7 discontinued discontinue VBN cord-010119-t1x9gknd 4818 8 , , , cord-010119-t1x9gknd 4818 9 the the DT cord-010119-t1x9gknd 4818 10 patient patient NN cord-010119-t1x9gknd 4818 11 was be VBD cord-010119-t1x9gknd 4818 12 successfully successfully RB cord-010119-t1x9gknd 4818 13 extubated extubate VBN cord-010119-t1x9gknd 4818 14 and and CC cord-010119-t1x9gknd 4818 15 rapidly rapidly RB cord-010119-t1x9gknd 4818 16 improved improve VBN cord-010119-t1x9gknd 4818 17 . . . cord-010119-t1x9gknd 4819 1 He -PRON- PRP cord-010119-t1x9gknd 4819 2 completely completely RB cord-010119-t1x9gknd 4819 3 returned return VBD cord-010119-t1x9gknd 4819 4 to to IN cord-010119-t1x9gknd 4819 5 baseline baseline NN cord-010119-t1x9gknd 4819 6 within within IN cord-010119-t1x9gknd 4819 7 24 24 CD cord-010119-t1x9gknd 4819 8 hours hour NNS cord-010119-t1x9gknd 4819 9 of of IN cord-010119-t1x9gknd 4819 10 onset onset NN cord-010119-t1x9gknd 4819 11 of of IN cord-010119-t1x9gknd 4819 12 the the DT cord-010119-t1x9gknd 4819 13 event event NN cord-010119-t1x9gknd 4819 14 . . . cord-010119-t1x9gknd 4820 1 Laboratory laboratory NN cord-010119-t1x9gknd 4820 2 investigation investigation NN cord-010119-t1x9gknd 4820 3 revealed reveal VBD cord-010119-t1x9gknd 4820 4 no no DT cord-010119-t1x9gknd 4820 5 signs sign NNS cord-010119-t1x9gknd 4820 6 of of IN cord-010119-t1x9gknd 4820 7 infectious infectious JJ cord-010119-t1x9gknd 4820 8 organisms organism NNS cord-010119-t1x9gknd 4820 9 or or CC cord-010119-t1x9gknd 4820 10 evidence evidence NN cord-010119-t1x9gknd 4820 11 of of IN cord-010119-t1x9gknd 4820 12 drugs drug NNS cord-010119-t1x9gknd 4820 13 of of IN cord-010119-t1x9gknd 4820 14 abuse abuse NN cord-010119-t1x9gknd 4820 15 . . . cord-010119-t1x9gknd 4821 1 Radiographic radiographic JJ cord-010119-t1x9gknd 4821 2 imaging imaging NN cord-010119-t1x9gknd 4821 3 and and CC cord-010119-t1x9gknd 4821 4 EEG EEG NNP cord-010119-t1x9gknd 4821 5 studies study NNS cord-010119-t1x9gknd 4821 6 showed show VBD cord-010119-t1x9gknd 4821 7 no no DT cord-010119-t1x9gknd 4821 8 abnormalities abnormality NNS cord-010119-t1x9gknd 4821 9 . . . cord-010119-t1x9gknd 4822 1 In in IN cord-010119-t1x9gknd 4822 2 addition addition NN cord-010119-t1x9gknd 4822 3 , , , cord-010119-t1x9gknd 4822 4 infectious infectious JJ cord-010119-t1x9gknd 4822 5 disease disease NN cord-010119-t1x9gknd 4822 6 marker marker NN cord-010119-t1x9gknd 4822 7 testing testing NN cord-010119-t1x9gknd 4822 8 performed perform VBN cord-010119-t1x9gknd 4822 9 by by IN cord-010119-t1x9gknd 4822 10 the the DT cord-010119-t1x9gknd 4822 11 blood blood NN cord-010119-t1x9gknd 4822 12 center center NN cord-010119-t1x9gknd 4822 13 laboratory laboratory NN cord-010119-t1x9gknd 4822 14 was be VBD cord-010119-t1x9gknd 4822 15 negative negative JJ cord-010119-t1x9gknd 4822 16 . . . cord-010119-t1x9gknd 4823 1 Investigation investigation NN cord-010119-t1x9gknd 4823 2 revealed reveal VBD cord-010119-t1x9gknd 4823 3 that that IN cord-010119-t1x9gknd 4823 4 the the DT cord-010119-t1x9gknd 4823 5 donor donor NN cord-010119-t1x9gknd 4823 6 was be VBD cord-010119-t1x9gknd 4823 7 experiencing experience VBG cord-010119-t1x9gknd 4823 8 high high JJ cord-010119-t1x9gknd 4823 9 levels level NNS cord-010119-t1x9gknd 4823 10 of of IN cord-010119-t1x9gknd 4823 11 stress stress NN cord-010119-t1x9gknd 4823 12 at at IN cord-010119-t1x9gknd 4823 13 school school NN cord-010119-t1x9gknd 4823 14 , , , cord-010119-t1x9gknd 4823 15 had have VBD cord-010119-t1x9gknd 4823 16 an an DT cord-010119-t1x9gknd 4823 17 aversion aversion NN cord-010119-t1x9gknd 4823 18 to to IN cord-010119-t1x9gknd 4823 19 the the DT cord-010119-t1x9gknd 4823 20 sight sight NN cord-010119-t1x9gknd 4823 21 of of IN cord-010119-t1x9gknd 4823 22 blood blood NN cord-010119-t1x9gknd 4823 23 , , , cord-010119-t1x9gknd 4823 24 and and CC cord-010119-t1x9gknd 4823 25 was be VBD cord-010119-t1x9gknd 4823 26 coerced coerce VBN cord-010119-t1x9gknd 4823 27 into into IN cord-010119-t1x9gknd 4823 28 donating donate VBG cord-010119-t1x9gknd 4823 29 by by IN cord-010119-t1x9gknd 4823 30 his -PRON- PRP$ cord-010119-t1x9gknd 4823 31 girlfriend girlfriend NN cord-010119-t1x9gknd 4823 32 and and CC cord-010119-t1x9gknd 4823 33 peers peer NNS cord-010119-t1x9gknd 4823 34 . . . cord-010119-t1x9gknd 4824 1 A a DT cord-010119-t1x9gknd 4824 2 week week NN cord-010119-t1x9gknd 4824 3 following follow VBG cord-010119-t1x9gknd 4824 4 hospital hospital NN cord-010119-t1x9gknd 4824 5 discharge discharge NN cord-010119-t1x9gknd 4824 6 , , , cord-010119-t1x9gknd 4824 7 the the DT cord-010119-t1x9gknd 4824 8 blood blood NN cord-010119-t1x9gknd 4824 9 center center NN cord-010119-t1x9gknd 4824 10 medical medical JJ cord-010119-t1x9gknd 4824 11 director director NN cord-010119-t1x9gknd 4824 12 contacted contact VBD cord-010119-t1x9gknd 4824 13 the the DT cord-010119-t1x9gknd 4824 14 donor donor NN cord-010119-t1x9gknd 4824 15 by by IN cord-010119-t1x9gknd 4824 16 phone phone NN cord-010119-t1x9gknd 4824 17 ; ; : cord-010119-t1x9gknd 4824 18 the the DT cord-010119-t1x9gknd 4824 19 donor donor NN cord-010119-t1x9gknd 4824 20 had have VBD cord-010119-t1x9gknd 4824 21 resumed resume VBN cord-010119-t1x9gknd 4824 22 his -PRON- PRP$ cord-010119-t1x9gknd 4824 23 normal normal JJ cord-010119-t1x9gknd 4824 24 routine routine NN cord-010119-t1x9gknd 4824 25 and and CC cord-010119-t1x9gknd 4824 26 was be VBD cord-010119-t1x9gknd 4824 27 attending attend VBG cord-010119-t1x9gknd 4824 28 his -PRON- PRP$ cord-010119-t1x9gknd 4824 29 graduate graduate JJ cord-010119-t1x9gknd 4824 30 level level NN cord-010119-t1x9gknd 4824 31 classes class NNS cord-010119-t1x9gknd 4824 32 . . . cord-010119-t1x9gknd 4825 1 Conclusion conclusion NN cord-010119-t1x9gknd 4825 2 : : : cord-010119-t1x9gknd 4826 1 To to IN cord-010119-t1x9gknd 4826 2 our -PRON- PRP$ cord-010119-t1x9gknd 4826 3 knowledge knowledge NN cord-010119-t1x9gknd 4826 4 , , , cord-010119-t1x9gknd 4826 5 this this DT cord-010119-t1x9gknd 4826 6 is be VBZ cord-010119-t1x9gknd 4826 7 the the DT cord-010119-t1x9gknd 4826 8 first first JJ cord-010119-t1x9gknd 4826 9 report report NN cord-010119-t1x9gknd 4826 10 of of IN cord-010119-t1x9gknd 4826 11 blood blood NN cord-010119-t1x9gknd 4826 12 donation donation NN cord-010119-t1x9gknd 4826 13 precipitating precipitate VBG cord-010119-t1x9gknd 4826 14 a a DT cord-010119-t1x9gknd 4826 15 transient transient JJ cord-010119-t1x9gknd 4826 16 acute acute JJ cord-010119-t1x9gknd 4826 17 delirium delirium NN cord-010119-t1x9gknd 4826 18 . . . cord-010119-t1x9gknd 4827 1 At at IN cord-010119-t1x9gknd 4827 2 the the DT cord-010119-t1x9gknd 4827 3 time time NN cord-010119-t1x9gknd 4827 4 of of IN cord-010119-t1x9gknd 4827 5 donation donation NN cord-010119-t1x9gknd 4827 6 , , , cord-010119-t1x9gknd 4827 7 the the DT cord-010119-t1x9gknd 4827 8 health health NN cord-010119-t1x9gknd 4827 9 status status NN cord-010119-t1x9gknd 4827 10 of of IN cord-010119-t1x9gknd 4827 11 all all DT cord-010119-t1x9gknd 4827 12 potential potential JJ cord-010119-t1x9gknd 4827 13 blood blood NN cord-010119-t1x9gknd 4827 14 donors donor NNS cord-010119-t1x9gknd 4827 15 is be VBZ cord-010119-t1x9gknd 4827 16 assessed assess VBN cord-010119-t1x9gknd 4827 17 to to TO cord-010119-t1x9gknd 4827 18 help help VB cord-010119-t1x9gknd 4827 19 ensure ensure VB cord-010119-t1x9gknd 4827 20 the the DT cord-010119-t1x9gknd 4827 21 safety safety NN cord-010119-t1x9gknd 4827 22 of of IN cord-010119-t1x9gknd 4827 23 the the DT cord-010119-t1x9gknd 4827 24 donor donor NN cord-010119-t1x9gknd 4827 25 and and CC cord-010119-t1x9gknd 4827 26 the the DT cord-010119-t1x9gknd 4827 27 recipient recipient NN cord-010119-t1x9gknd 4827 28 . . . cord-010119-t1x9gknd 4828 1 The the DT cord-010119-t1x9gknd 4828 2 health health NN cord-010119-t1x9gknd 4828 3 questionnaire questionnaire NN cord-010119-t1x9gknd 4828 4 , , , cord-010119-t1x9gknd 4828 5 physical physical JJ cord-010119-t1x9gknd 4828 6 exam exam NN cord-010119-t1x9gknd 4828 7 , , , cord-010119-t1x9gknd 4828 8 vital vital JJ cord-010119-t1x9gknd 4828 9 signs sign NNS cord-010119-t1x9gknd 4828 10 , , , cord-010119-t1x9gknd 4828 11 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4828 12 level level NN cord-010119-t1x9gknd 4828 13 , , , cord-010119-t1x9gknd 4828 14 and and CC cord-010119-t1x9gknd 4828 15 infectious infectious JJ cord-010119-t1x9gknd 4828 16 disease disease NN cord-010119-t1x9gknd 4828 17 testing testing NN cord-010119-t1x9gknd 4828 18 help help NN cord-010119-t1x9gknd 4828 19 to to TO cord-010119-t1x9gknd 4828 20 identify identify VB cord-010119-t1x9gknd 4828 21 overt overt JJ cord-010119-t1x9gknd 4828 22 signs sign NNS cord-010119-t1x9gknd 4828 23 of of IN cord-010119-t1x9gknd 4828 24 medical medical JJ cord-010119-t1x9gknd 4828 25 illness illness NN cord-010119-t1x9gknd 4828 26 that that WDT cord-010119-t1x9gknd 4828 27 may may MD cord-010119-t1x9gknd 4828 28 disqualify disqualify VB cord-010119-t1x9gknd 4828 29 a a DT cord-010119-t1x9gknd 4828 30 donor donor NN cord-010119-t1x9gknd 4828 31 . . . cord-010119-t1x9gknd 4829 1 However however RB cord-010119-t1x9gknd 4829 2 , , , cord-010119-t1x9gknd 4829 3 routine routine JJ cord-010119-t1x9gknd 4829 4 donor donor NN cord-010119-t1x9gknd 4829 5 screening screening NN cord-010119-t1x9gknd 4829 6 does do VBZ cord-010119-t1x9gknd 4829 7 not not RB cord-010119-t1x9gknd 4829 8 explicitly explicitly RB cord-010119-t1x9gknd 4829 9 evaluate evaluate VB cord-010119-t1x9gknd 4829 10 mental mental JJ cord-010119-t1x9gknd 4829 11 health health NN cord-010119-t1x9gknd 4829 12 issues issue NNS cord-010119-t1x9gknd 4829 13 , , , cord-010119-t1x9gknd 4829 14 both both CC cord-010119-t1x9gknd 4829 15 diagnosed diagnose VBD cord-010119-t1x9gknd 4829 16 and and CC cord-010119-t1x9gknd 4829 17 undiagnosed undiagnosed JJ cord-010119-t1x9gknd 4829 18 . . . cord-010119-t1x9gknd 4830 1 Although although IN cord-010119-t1x9gknd 4830 2 exceedingly exceedingly RB cord-010119-t1x9gknd 4830 3 rare rare JJ cord-010119-t1x9gknd 4830 4 , , , cord-010119-t1x9gknd 4830 5 this this DT cord-010119-t1x9gknd 4830 6 case case NN cord-010119-t1x9gknd 4830 7 highlights highlight VBZ cord-010119-t1x9gknd 4830 8 the the DT cord-010119-t1x9gknd 4830 9 limitations limitation NNS cord-010119-t1x9gknd 4830 10 of of IN cord-010119-t1x9gknd 4830 11 donor donor NN cord-010119-t1x9gknd 4830 12 screening screening NN cord-010119-t1x9gknd 4830 13 to to TO cord-010119-t1x9gknd 4830 14 identify identify VB cord-010119-t1x9gknd 4830 15 donors donor NNS cord-010119-t1x9gknd 4830 16 who who WP cord-010119-t1x9gknd 4830 17 may may MD cord-010119-t1x9gknd 4830 18 be be VB cord-010119-t1x9gknd 4830 19 at at IN cord-010119-t1x9gknd 4830 20 risk risk NN cord-010119-t1x9gknd 4830 21 for for IN cord-010119-t1x9gknd 4830 22 mental mental JJ cord-010119-t1x9gknd 4830 23 health health NN cord-010119-t1x9gknd 4830 24 adverse adverse JJ cord-010119-t1x9gknd 4830 25 reactions reaction NNS cord-010119-t1x9gknd 4830 26 when when WRB cord-010119-t1x9gknd 4830 27 donating donate VBG cord-010119-t1x9gknd 4830 28 blood blood NN cord-010119-t1x9gknd 4830 29 . . . cord-010119-t1x9gknd 4831 1 A a DT cord-010119-t1x9gknd 4831 2 Targeted target VBN cord-010119-t1x9gknd 4831 3 Approach Approach NNP cord-010119-t1x9gknd 4831 4 to to IN cord-010119-t1x9gknd 4831 5 Increasing increase VBG cord-010119-t1x9gknd 4831 6 the the DT cord-010119-t1x9gknd 4831 7 African african JJ cord-010119-t1x9gknd 4831 8 American American NNP cord-010119-t1x9gknd 4831 9 Blood Blood NNP cord-010119-t1x9gknd 4831 10 Donor Donor NNP cord-010119-t1x9gknd 4831 11 Pool Pool NNP cord-010119-t1x9gknd 4832 1 Arnethea Arnethea NNP cord-010119-t1x9gknd 4832 2 Sutton Sutton NNP cord-010119-t1x9gknd 4832 3 * * NFP cord-010119-t1x9gknd 4832 4 1 1 CD cord-010119-t1x9gknd 4832 5 , , , cord-010119-t1x9gknd 4832 6 William William NNP cord-010119-t1x9gknd 4832 7 Korzun Korzun NNP cord-010119-t1x9gknd 4832 8 1 1 CD cord-010119-t1x9gknd 4832 9 , , , cord-010119-t1x9gknd 4832 10 Teresa Teresa NNP cord-010119-t1x9gknd 4832 11 Nadder Nadder NNP cord-010119-t1x9gknd 4832 12 1 1 CD cord-010119-t1x9gknd 4832 13 , , , cord-010119-t1x9gknd 4832 14 Susan Susan NNP cord-010119-t1x9gknd 4832 15 Roseff Roseff NNP cord-010119-t1x9gknd 4832 16 2 2 CD cord-010119-t1x9gknd 4832 17 and and CC cord-010119-t1x9gknd 4832 18 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 4832 19 Ripley Ripley NNP cord-010119-t1x9gknd 4832 20 1 1 CD cord-010119-t1x9gknd 4832 21 . . . cord-010119-t1x9gknd 4832 22 1 1 CD cord-010119-t1x9gknd 4832 23 Virginia Virginia NNP cord-010119-t1x9gknd 4832 24 Commonwealth Commonwealth NNP cord-010119-t1x9gknd 4832 25 University University NNP cord-010119-t1x9gknd 4832 26 , , , cord-010119-t1x9gknd 4832 27 2 2 CD cord-010119-t1x9gknd 4832 28 Virginia Virginia NNP cord-010119-t1x9gknd 4832 29 Commonwealth Commonwealth NNP cord-010119-t1x9gknd 4832 30 University University NNP cord-010119-t1x9gknd 4832 31 Medical Medical NNP cord-010119-t1x9gknd 4832 32 Center Center NNP cord-010119-t1x9gknd 4832 33 Background Background NNP cord-010119-t1x9gknd 4832 34 / / SYM cord-010119-t1x9gknd 4832 35 Case Case NNP cord-010119-t1x9gknd 4832 36 Studies Studies NNPS cord-010119-t1x9gknd 4832 37 : : : cord-010119-t1x9gknd 4832 38 A a DT cord-010119-t1x9gknd 4832 39 continuous continuous JJ cord-010119-t1x9gknd 4832 40 need need NN cord-010119-t1x9gknd 4832 41 for for IN cord-010119-t1x9gknd 4832 42 blood blood NN cord-010119-t1x9gknd 4832 43 products product NNS cord-010119-t1x9gknd 4832 44 for for IN cord-010119-t1x9gknd 4832 45 those those DT cord-010119-t1x9gknd 4832 46 who who WP cord-010119-t1x9gknd 4832 47 require require VBP cord-010119-t1x9gknd 4832 48 frequent frequent JJ cord-010119-t1x9gknd 4832 49 transfusions transfusion NNS cord-010119-t1x9gknd 4832 50 , , , cord-010119-t1x9gknd 4832 51 such such JJ cord-010119-t1x9gknd 4832 52 as as IN cord-010119-t1x9gknd 4832 53 individuals individual NNS cord-010119-t1x9gknd 4832 54 with with IN cord-010119-t1x9gknd 4832 55 sickle sickle NN cord-010119-t1x9gknd 4832 56 cell cell NN cord-010119-t1x9gknd 4832 57 disease disease NN cord-010119-t1x9gknd 4832 58 who who WP cord-010119-t1x9gknd 4832 59 could could MD cord-010119-t1x9gknd 4832 60 benefit benefit VB cord-010119-t1x9gknd 4832 61 from from IN cord-010119-t1x9gknd 4832 62 products product NNS cord-010119-t1x9gknd 4832 63 collected collect VBN cord-010119-t1x9gknd 4832 64 from from IN cord-010119-t1x9gknd 4832 65 African african JJ cord-010119-t1x9gknd 4832 66 American american JJ cord-010119-t1x9gknd 4832 67 donors donor NNS cord-010119-t1x9gknd 4832 68 , , , cord-010119-t1x9gknd 4832 69 warrants warrant VBZ cord-010119-t1x9gknd 4832 70 the the DT cord-010119-t1x9gknd 4832 71 need need NN cord-010119-t1x9gknd 4832 72 for for IN cord-010119-t1x9gknd 4832 73 targeted target VBN cord-010119-t1x9gknd 4832 74 interventions intervention NNS cord-010119-t1x9gknd 4832 75 to to TO cord-010119-t1x9gknd 4832 76 increase increase VB cord-010119-t1x9gknd 4832 77 blood blood NN cord-010119-t1x9gknd 4832 78 donations donation NNS cord-010119-t1x9gknd 4832 79 from from IN cord-010119-t1x9gknd 4832 80 underrepresented underrepresented JJ cord-010119-t1x9gknd 4832 81 populations population NNS cord-010119-t1x9gknd 4832 82 . . . cord-010119-t1x9gknd 4833 1 One one CD cord-010119-t1x9gknd 4833 2 population population NN cord-010119-t1x9gknd 4833 3 in in IN cord-010119-t1x9gknd 4833 4 particular particular JJ cord-010119-t1x9gknd 4833 5 , , , cord-010119-t1x9gknd 4833 6 African African NNP cord-010119-t1x9gknd 4833 7 Americans Americans NNPS cord-010119-t1x9gknd 4833 8 , , , cord-010119-t1x9gknd 4833 9 only only RB cord-010119-t1x9gknd 4833 10 account account VBP cord-010119-t1x9gknd 4833 11 for for IN cord-010119-t1x9gknd 4833 12 1 1 CD cord-010119-t1x9gknd 4833 13 % % NN cord-010119-t1x9gknd 4833 14 of of IN cord-010119-t1x9gknd 4833 15 blood blood NN cord-010119-t1x9gknd 4833 16 donors donor NNS cord-010119-t1x9gknd 4833 17 in in IN cord-010119-t1x9gknd 4833 18 the the DT cord-010119-t1x9gknd 4833 19 United United NNP cord-010119-t1x9gknd 4833 20 States States NNP cord-010119-t1x9gknd 4833 21 . . . cord-010119-t1x9gknd 4834 1 Literature literature NN cord-010119-t1x9gknd 4834 2 indicates indicate VBZ cord-010119-t1x9gknd 4834 3 numerous numerous JJ cord-010119-t1x9gknd 4834 4 reasons reason NNS cord-010119-t1x9gknd 4834 5 why why WRB cord-010119-t1x9gknd 4834 6 this this DT cord-010119-t1x9gknd 4834 7 population population NN cord-010119-t1x9gknd 4834 8 is be VBZ cord-010119-t1x9gknd 4834 9 underrepresented underrepresente VBN cord-010119-t1x9gknd 4834 10 amongst amongst IN cord-010119-t1x9gknd 4834 11 donors donor NNS cord-010119-t1x9gknd 4834 12 , , , cord-010119-t1x9gknd 4834 13 including include VBG cord-010119-t1x9gknd 4834 14 fear fear NN cord-010119-t1x9gknd 4834 15 , , , cord-010119-t1x9gknd 4834 16 lack lack NN cord-010119-t1x9gknd 4834 17 of of IN cord-010119-t1x9gknd 4834 18 knowledge knowledge NN cord-010119-t1x9gknd 4834 19 about about IN cord-010119-t1x9gknd 4834 20 the the DT cord-010119-t1x9gknd 4834 21 blood blood NN cord-010119-t1x9gknd 4834 22 donation donation NN cord-010119-t1x9gknd 4834 23 , , , cord-010119-t1x9gknd 4834 24 and and CC cord-010119-t1x9gknd 4834 25 specific specific JJ cord-010119-t1x9gknd 4834 26 to to IN cord-010119-t1x9gknd 4834 27 this this DT cord-010119-t1x9gknd 4834 28 population population NN cord-010119-t1x9gknd 4834 29 , , , cord-010119-t1x9gknd 4834 30 lack lack NN cord-010119-t1x9gknd 4834 31 of of IN cord-010119-t1x9gknd 4834 32 trust trust NN cord-010119-t1x9gknd 4834 33 in in IN cord-010119-t1x9gknd 4834 34 the the DT cord-010119-t1x9gknd 4834 35 medical medical JJ cord-010119-t1x9gknd 4834 36 community community NN cord-010119-t1x9gknd 4834 37 . . . cord-010119-t1x9gknd 4835 1 Study Study NNP cord-010119-t1x9gknd 4835 2 Design Design NNP cord-010119-t1x9gknd 4835 3 / / SYM cord-010119-t1x9gknd 4835 4 Method method NN cord-010119-t1x9gknd 4835 5 : : : cord-010119-t1x9gknd 4836 1 African African NNP cord-010119-t1x9gknd 4836 2 Americans Americans NNPS cord-010119-t1x9gknd 4836 3 in in IN cord-010119-t1x9gknd 4836 4 Richmond Richmond NNP cord-010119-t1x9gknd 4836 5 and and CC cord-010119-t1x9gknd 4836 6 Norfolk Norfolk NNP cord-010119-t1x9gknd 4836 7 , , , cord-010119-t1x9gknd 4836 8 Virginia Virginia NNP cord-010119-t1x9gknd 4836 9 were be VBD cord-010119-t1x9gknd 4836 10 recruited recruit VBN cord-010119-t1x9gknd 4836 11 through through IN cord-010119-t1x9gknd 4836 12 churches church NNS cord-010119-t1x9gknd 4836 13 and and CC cord-010119-t1x9gknd 4836 14 local local JJ cord-010119-t1x9gknd 4836 15 universities university NNS cord-010119-t1x9gknd 4836 16 . . . cord-010119-t1x9gknd 4837 1 The the DT cord-010119-t1x9gknd 4837 2 study study NN cord-010119-t1x9gknd 4837 3 's 's POS cord-010119-t1x9gknd 4837 4 aims aim NNS cord-010119-t1x9gknd 4837 5 were be VBD cord-010119-t1x9gknd 4837 6 to to TO cord-010119-t1x9gknd 4837 7 develop develop VB cord-010119-t1x9gknd 4837 8 , , , cord-010119-t1x9gknd 4837 9 implement implement VB cord-010119-t1x9gknd 4837 10 , , , cord-010119-t1x9gknd 4837 11 and and CC cord-010119-t1x9gknd 4837 12 assess assess VB cord-010119-t1x9gknd 4837 13 a a DT cord-010119-t1x9gknd 4837 14 targeted target VBN cord-010119-t1x9gknd 4837 15 educational educational JJ cord-010119-t1x9gknd 4837 16 approach approach NN cord-010119-t1x9gknd 4837 17 incorporating incorporate VBG cord-010119-t1x9gknd 4837 18 the the DT cord-010119-t1x9gknd 4837 19 Theory Theory NNP cord-010119-t1x9gknd 4837 20 of of IN cord-010119-t1x9gknd 4837 21 Planned Planned NNP cord-010119-t1x9gknd 4837 22 Behavior Behavior NNP cord-010119-t1x9gknd 4837 23 and and CC cord-010119-t1x9gknd 4837 24 various various JJ cord-010119-t1x9gknd 4837 25 teaching teaching NN cord-010119-t1x9gknd 4837 26 methods method NNS cord-010119-t1x9gknd 4837 27 , , , cord-010119-t1x9gknd 4837 28 to to TO cord-010119-t1x9gknd 4837 29 develop develop VB cord-010119-t1x9gknd 4837 30 and and CC cord-010119-t1x9gknd 4837 31 implement implement VB cord-010119-t1x9gknd 4837 32 a a DT cord-010119-t1x9gknd 4837 33 survey survey NN cord-010119-t1x9gknd 4837 34 to to TO cord-010119-t1x9gknd 4837 35 evaluate evaluate VB cord-010119-t1x9gknd 4837 36 participants participant NNS cord-010119-t1x9gknd 4837 37 ' ' POS cord-010119-t1x9gknd 4837 38 feelings feeling NNS cord-010119-t1x9gknd 4837 39 , , , cord-010119-t1x9gknd 4837 40 attitudes attitude NNS cord-010119-t1x9gknd 4837 41 , , , cord-010119-t1x9gknd 4837 42 and and CC cord-010119-t1x9gknd 4837 43 intent intent JJ cord-010119-t1x9gknd 4837 44 to to TO cord-010119-t1x9gknd 4837 45 donate donate VB cord-010119-t1x9gknd 4837 46 , , , cord-010119-t1x9gknd 4837 47 and and CC cord-010119-t1x9gknd 4837 48 to to TO cord-010119-t1x9gknd 4837 49 motivate motivate VB cord-010119-t1x9gknd 4837 50 African african JJ cord-010119-t1x9gknd 4837 51 Americans Americans NNPS cord-010119-t1x9gknd 4837 52 non non JJ cord-010119-t1x9gknd 4837 53 - - NNS cord-010119-t1x9gknd 4837 54 donors donor NNS cord-010119-t1x9gknd 4837 55 to to TO cord-010119-t1x9gknd 4837 56 attempt attempt VB cord-010119-t1x9gknd 4837 57 to to TO cord-010119-t1x9gknd 4837 58 donate donate VB cord-010119-t1x9gknd 4837 59 blood blood NN cord-010119-t1x9gknd 4837 60 . . . cord-010119-t1x9gknd 4838 1 Participants participant NNS cord-010119-t1x9gknd 4838 2 attended attend VBD cord-010119-t1x9gknd 4838 3 a a DT cord-010119-t1x9gknd 4838 4 1-hour 1-hour CD cord-010119-t1x9gknd 4838 5 educational educational JJ cord-010119-t1x9gknd 4838 6 session session NN cord-010119-t1x9gknd 4838 7 where where WRB cord-010119-t1x9gknd 4838 8 they -PRON- PRP cord-010119-t1x9gknd 4838 9 were be VBD cord-010119-t1x9gknd 4838 10 educated educate VBN cord-010119-t1x9gknd 4838 11 on on IN cord-010119-t1x9gknd 4838 12 the the DT cord-010119-t1x9gknd 4838 13 importance importance NN cord-010119-t1x9gknd 4838 14 of of IN cord-010119-t1x9gknd 4838 15 red red JJ cord-010119-t1x9gknd 4838 16 blood blood NN cord-010119-t1x9gknd 4838 17 cell cell NN cord-010119-t1x9gknd 4838 18 donations donation NNS cord-010119-t1x9gknd 4838 19 from from IN cord-010119-t1x9gknd 4838 20 African african JJ cord-010119-t1x9gknd 4838 21 Americans Americans NNPS cord-010119-t1x9gknd 4838 22 . . . cord-010119-t1x9gknd 4839 1 Participants participant NNS cord-010119-t1x9gknd 4839 2 completed complete VBD cord-010119-t1x9gknd 4839 3 three three CD cord-010119-t1x9gknd 4839 4 surveys survey NNS cord-010119-t1x9gknd 4839 5 -one -one CD cord-010119-t1x9gknd 4839 6 before before IN cord-010119-t1x9gknd 4839 7 the the DT cord-010119-t1x9gknd 4839 8 session session NN cord-010119-t1x9gknd 4839 9 , , , cord-010119-t1x9gknd 4839 10 one one CD cord-010119-t1x9gknd 4839 11 directly directly RB cord-010119-t1x9gknd 4839 12 after after IN cord-010119-t1x9gknd 4839 13 the the DT cord-010119-t1x9gknd 4839 14 session session NN cord-010119-t1x9gknd 4839 15 and and CC cord-010119-t1x9gknd 4839 16 one one CD cord-010119-t1x9gknd 4839 17 , , , cord-010119-t1x9gknd 4839 18 two two CD cord-010119-t1x9gknd 4839 19 months month NNS cord-010119-t1x9gknd 4839 20 after after IN cord-010119-t1x9gknd 4839 21 the the DT cord-010119-t1x9gknd 4839 22 session session NN cord-010119-t1x9gknd 4839 23 . . . cord-010119-t1x9gknd 4840 1 A a DT cord-010119-t1x9gknd 4840 2 two two CD cord-010119-t1x9gknd 4840 3 - - HYPH cord-010119-t1x9gknd 4840 4 proportion proportion NN cord-010119-t1x9gknd 4840 5 z z NN cord-010119-t1x9gknd 4840 6 - - HYPH cord-010119-t1x9gknd 4840 7 test test NN cord-010119-t1x9gknd 4840 8 was be VBD cord-010119-t1x9gknd 4840 9 used use VBN cord-010119-t1x9gknd 4840 10 to to TO cord-010119-t1x9gknd 4840 11 compare compare VB cord-010119-t1x9gknd 4840 12 the the DT cord-010119-t1x9gknd 4840 13 known know VBN cord-010119-t1x9gknd 4840 14 proportion proportion NN cord-010119-t1x9gknd 4840 15 of of IN cord-010119-t1x9gknd 4840 16 African african JJ cord-010119-t1x9gknd 4840 17 Americans Americans NNPS cord-010119-t1x9gknd 4840 18 who who WP cord-010119-t1x9gknd 4840 19 present present VBP cord-010119-t1x9gknd 4840 20 to to TO cord-010119-t1x9gknd 4840 21 donate donate VB cord-010119-t1x9gknd 4840 22 in in IN cord-010119-t1x9gknd 4840 23 the the DT cord-010119-t1x9gknd 4840 24 study study NN cord-010119-t1x9gknd 4840 25 areas area NNS cord-010119-t1x9gknd 4840 26 to to IN cord-010119-t1x9gknd 4840 27 those those DT cord-010119-t1x9gknd 4840 28 who who WP cord-010119-t1x9gknd 4840 29 presented present VBD cord-010119-t1x9gknd 4840 30 to to TO cord-010119-t1x9gknd 4840 31 donate donate VB cord-010119-t1x9gknd 4840 32 in in IN cord-010119-t1x9gknd 4840 33 this this DT cord-010119-t1x9gknd 4840 34 study study NN cord-010119-t1x9gknd 4840 35 , , , cord-010119-t1x9gknd 4840 36 while while IN cord-010119-t1x9gknd 4840 37 regression regression NN cord-010119-t1x9gknd 4840 38 analysis analysis NN cord-010119-t1x9gknd 4840 39 was be VBD cord-010119-t1x9gknd 4840 40 used use VBN cord-010119-t1x9gknd 4840 41 to to TO cord-010119-t1x9gknd 4840 42 estimate estimate VB cord-010119-t1x9gknd 4840 43 the the DT cord-010119-t1x9gknd 4840 44 relationships relationship NNS cord-010119-t1x9gknd 4840 45 among among IN cord-010119-t1x9gknd 4840 46 survey survey NN cord-010119-t1x9gknd 4840 47 variables variable NNS cord-010119-t1x9gknd 4840 48 . . . cord-010119-t1x9gknd 4841 1 Results result NNS cord-010119-t1x9gknd 4841 2 / / SYM cord-010119-t1x9gknd 4841 3 Finding finding NN cord-010119-t1x9gknd 4841 4 : : : cord-010119-t1x9gknd 4841 5 A a DT cord-010119-t1x9gknd 4841 6 total total NN cord-010119-t1x9gknd 4841 7 of of IN cord-010119-t1x9gknd 4841 8 142 142 CD cord-010119-t1x9gknd 4841 9 subjects subject NNS cord-010119-t1x9gknd 4841 10 were be VBD cord-010119-t1x9gknd 4841 11 included include VBN cord-010119-t1x9gknd 4841 12 in in IN cord-010119-t1x9gknd 4841 13 the the DT cord-010119-t1x9gknd 4841 14 data data NN cord-010119-t1x9gknd 4841 15 analysis analysis NN cord-010119-t1x9gknd 4841 16 . . . cord-010119-t1x9gknd 4842 1 Sixteen sixteen CD cord-010119-t1x9gknd 4842 2 percent percent NN cord-010119-t1x9gknd 4842 3 of of IN cord-010119-t1x9gknd 4842 4 the the DT cord-010119-t1x9gknd 4842 5 study study NN cord-010119-t1x9gknd 4842 6 participants participant NNS cord-010119-t1x9gknd 4842 7 presented present VBN cord-010119-t1x9gknd 4842 8 to to TO cord-010119-t1x9gknd 4842 9 donate donate VB cord-010119-t1x9gknd 4842 10 as as IN cord-010119-t1x9gknd 4842 11 a a DT cord-010119-t1x9gknd 4842 12 result result NN cord-010119-t1x9gknd 4842 13 of of IN cord-010119-t1x9gknd 4842 14 attending attend VBG cord-010119-t1x9gknd 4842 15 the the DT cord-010119-t1x9gknd 4842 16 educational educational JJ cord-010119-t1x9gknd 4842 17 session session NN cord-010119-t1x9gknd 4842 18 . . . cord-010119-t1x9gknd 4843 1 This this DT cord-010119-t1x9gknd 4843 2 resulted result VBD cord-010119-t1x9gknd 4843 3 in in IN cord-010119-t1x9gknd 4843 4 a a DT cord-010119-t1x9gknd 4843 5 statistically statistically RB cord-010119-t1x9gknd 4843 6 significantly significantly RB cord-010119-t1x9gknd 4843 7 higher high JJR cord-010119-t1x9gknd 4843 8 proportion proportion NN cord-010119-t1x9gknd 4843 9 of of IN cord-010119-t1x9gknd 4843 10 African african JJ cord-010119-t1x9gknd 4843 11 Americans Americans NNPS cord-010119-t1x9gknd 4843 12 presenting present VBG cord-010119-t1x9gknd 4843 13 to to TO cord-010119-t1x9gknd 4843 14 donate donate VB cord-010119-t1x9gknd 4843 15 than than IN cord-010119-t1x9gknd 4843 16 the the DT cord-010119-t1x9gknd 4843 17 current current JJ cord-010119-t1x9gknd 4843 18 proportion proportion NN cord-010119-t1x9gknd 4843 19 in in IN cord-010119-t1x9gknd 4843 20 the the DT cord-010119-t1x9gknd 4843 21 areas area NNS cord-010119-t1x9gknd 4843 22 of of IN cord-010119-t1x9gknd 4843 23 the the DT cord-010119-t1x9gknd 4843 24 state state NN cord-010119-t1x9gknd 4843 25 where where WRB cord-010119-t1x9gknd 4843 26 this this DT cord-010119-t1x9gknd 4843 27 study study NN cord-010119-t1x9gknd 4843 28 was be VBD cord-010119-t1x9gknd 4843 29 conducted conduct VBN cord-010119-t1x9gknd 4843 30 . . . cord-010119-t1x9gknd 4844 1 Results result NNS cord-010119-t1x9gknd 4844 2 from from IN cord-010119-t1x9gknd 4844 3 the the DT cord-010119-t1x9gknd 4844 4 first first JJ cord-010119-t1x9gknd 4844 5 two two CD cord-010119-t1x9gknd 4844 6 surveys survey NNS cord-010119-t1x9gknd 4844 7 indicated indicate VBD cord-010119-t1x9gknd 4844 8 that that IN cord-010119-t1x9gknd 4844 9 subjective subjective JJ cord-010119-t1x9gknd 4844 10 norm norm NN cord-010119-t1x9gknd 4844 11 and and CC cord-010119-t1x9gknd 4844 12 attitude attitude NN cord-010119-t1x9gknd 4844 13 were be VBD cord-010119-t1x9gknd 4844 14 significant significant JJ cord-010119-t1x9gknd 4844 15 predictors predictor NNS cord-010119-t1x9gknd 4844 16 of of IN cord-010119-t1x9gknd 4844 17 one one NN cord-010119-t1x9gknd 4844 18 's 's POS cord-010119-t1x9gknd 4844 19 intent intent NN cord-010119-t1x9gknd 4844 20 to to TO cord-010119-t1x9gknd 4844 21 donate donate VB cord-010119-t1x9gknd 4844 22 blood blood NN cord-010119-t1x9gknd 4844 23 , , , cord-010119-t1x9gknd 4844 24 while while IN cord-010119-t1x9gknd 4844 25 perceived perceive VBN cord-010119-t1x9gknd 4844 26 behavioral behavioral JJ cord-010119-t1x9gknd 4844 27 control control NN cord-010119-t1x9gknd 4844 28 was be VBD cord-010119-t1x9gknd 4844 29 not not RB cord-010119-t1x9gknd 4844 30 a a DT cord-010119-t1x9gknd 4844 31 factor factor NN cord-010119-t1x9gknd 4844 32 . . . cord-010119-t1x9gknd 4845 1 The the DT cord-010119-t1x9gknd 4845 2 educational educational JJ cord-010119-t1x9gknd 4845 3 session session NN cord-010119-t1x9gknd 4845 4 increased increase VBD cord-010119-t1x9gknd 4845 5 survey survey NN cord-010119-t1x9gknd 4845 6 scores score NNS cord-010119-t1x9gknd 4845 7 related relate VBN cord-010119-t1x9gknd 4845 8 to to IN cord-010119-t1x9gknd 4845 9 intent intent NN cord-010119-t1x9gknd 4845 10 to to TO cord-010119-t1x9gknd 4845 11 donate donate VB cord-010119-t1x9gknd 4845 12 in in IN cord-010119-t1x9gknd 4845 13 comparison comparison NN cord-010119-t1x9gknd 4845 14 to to IN cord-010119-t1x9gknd 4845 15 scores score NNS cord-010119-t1x9gknd 4845 16 obtained obtain VBN cord-010119-t1x9gknd 4845 17 prior prior RB cord-010119-t1x9gknd 4845 18 to to IN cord-010119-t1x9gknd 4845 19 the the DT cord-010119-t1x9gknd 4845 20 session session NN cord-010119-t1x9gknd 4845 21 . . . cord-010119-t1x9gknd 4846 1 Conclusion conclusion NN cord-010119-t1x9gknd 4846 2 : : : cord-010119-t1x9gknd 4847 1 This this DT cord-010119-t1x9gknd 4847 2 study study NN cord-010119-t1x9gknd 4847 3 shows show VBZ cord-010119-t1x9gknd 4847 4 that that IN cord-010119-t1x9gknd 4847 5 a a DT cord-010119-t1x9gknd 4847 6 targeted target VBN cord-010119-t1x9gknd 4847 7 educational educational JJ cord-010119-t1x9gknd 4847 8 program program NN cord-010119-t1x9gknd 4847 9 can can MD cord-010119-t1x9gknd 4847 10 change change VB cord-010119-t1x9gknd 4847 11 attitudes attitude NNS cord-010119-t1x9gknd 4847 12 toward toward IN cord-010119-t1x9gknd 4847 13 blood blood NN cord-010119-t1x9gknd 4847 14 donations donation NNS cord-010119-t1x9gknd 4847 15 in in IN cord-010119-t1x9gknd 4847 16 African african JJ cord-010119-t1x9gknd 4847 17 Americans Americans NNPS cord-010119-t1x9gknd 4847 18 resulting result VBG cord-010119-t1x9gknd 4847 19 in in IN cord-010119-t1x9gknd 4847 20 an an DT cord-010119-t1x9gknd 4847 21 increase increase NN cord-010119-t1x9gknd 4847 22 in in IN cord-010119-t1x9gknd 4847 23 new new JJ cord-010119-t1x9gknd 4847 24 blood blood NN cord-010119-t1x9gknd 4847 25 donors donor NNS cord-010119-t1x9gknd 4847 26 . . . cord-010119-t1x9gknd 4848 1 Additional additional JJ cord-010119-t1x9gknd 4848 2 studies study NNS cord-010119-t1x9gknd 4848 3 are be VBP cord-010119-t1x9gknd 4848 4 needed need VBN cord-010119-t1x9gknd 4848 5 to to TO cord-010119-t1x9gknd 4848 6 see see VB cord-010119-t1x9gknd 4848 7 if if IN cord-010119-t1x9gknd 4848 8 this this DT cord-010119-t1x9gknd 4848 9 behavior behavior NN cord-010119-t1x9gknd 4848 10 will will MD cord-010119-t1x9gknd 4848 11 continue continue VB cord-010119-t1x9gknd 4848 12 and and CC cord-010119-t1x9gknd 4848 13 whether whether IN cord-010119-t1x9gknd 4848 14 African african JJ cord-010119-t1x9gknd 4848 15 Americans Americans NNPS cord-010119-t1x9gknd 4848 16 can can MD cord-010119-t1x9gknd 4848 17 influence influence VB cord-010119-t1x9gknd 4848 18 their -PRON- PRP$ cord-010119-t1x9gknd 4848 19 community community NN cord-010119-t1x9gknd 4848 20 to to TO cord-010119-t1x9gknd 4848 21 increase increase VB cord-010119-t1x9gknd 4848 22 awareness awareness NN cord-010119-t1x9gknd 4848 23 and and CC cord-010119-t1x9gknd 4848 24 motivation motivation NN cord-010119-t1x9gknd 4848 25 for for IN cord-010119-t1x9gknd 4848 26 life life NN cord-010119-t1x9gknd 4848 27 - - HYPH cord-010119-t1x9gknd 4848 28 long long JJ cord-010119-t1x9gknd 4848 29 blood blood NN cord-010119-t1x9gknd 4848 30 donation donation NN cord-010119-t1x9gknd 4848 31 . . . cord-010119-t1x9gknd 4849 1 were be VBD cord-010119-t1x9gknd 4849 2 from from IN cord-010119-t1x9gknd 4849 3 female female JJ cord-010119-t1x9gknd 4849 4 basic basic JJ cord-010119-t1x9gknd 4849 5 trainees trainee NNS cord-010119-t1x9gknd 4850 1 Conclusion conclusion NN cord-010119-t1x9gknd 4850 2 : : : cord-010119-t1x9gknd 4850 3 The the DT cord-010119-t1x9gknd 4850 4 significant significant JJ cord-010119-t1x9gknd 4850 5 increase increase NN cord-010119-t1x9gknd 4850 6 in in IN cord-010119-t1x9gknd 4850 7 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4850 8 deferrals deferral NNS cord-010119-t1x9gknd 4850 9 at at IN cord-010119-t1x9gknd 4850 10 Basic Basic NNP cord-010119-t1x9gknd 4850 11 Training Training NNP cord-010119-t1x9gknd 4850 12 Site site NN cord-010119-t1x9gknd 4850 13 A a NN cord-010119-t1x9gknd 4850 14 from from IN cord-010119-t1x9gknd 4850 15 2015 2015 CD cord-010119-t1x9gknd 4850 16 to to IN cord-010119-t1x9gknd 4850 17 2016 2016 CD cord-010119-t1x9gknd 4850 18 could could MD cord-010119-t1x9gknd 4850 19 be be VB cord-010119-t1x9gknd 4850 20 a a DT cord-010119-t1x9gknd 4850 21 result result NN cord-010119-t1x9gknd 4850 22 of of IN cord-010119-t1x9gknd 4850 23 a a DT cord-010119-t1x9gknd 4850 24 change change NN cord-010119-t1x9gknd 4850 25 in in IN cord-010119-t1x9gknd 4850 26 the the DT cord-010119-t1x9gknd 4850 27 blood blood NN cord-010119-t1x9gknd 4850 28 drive drive NN cord-010119-t1x9gknd 4850 29 timing timing NN cord-010119-t1x9gknd 4850 30 of of IN cord-010119-t1x9gknd 4850 31 the the DT cord-010119-t1x9gknd 4850 32 training training NN cord-010119-t1x9gknd 4850 33 schedule schedule NN cord-010119-t1x9gknd 4850 34 of of IN cord-010119-t1x9gknd 4850 35 that that DT cord-010119-t1x9gknd 4850 36 location location NN cord-010119-t1x9gknd 4850 37 . . . cord-010119-t1x9gknd 4851 1 In in IN cord-010119-t1x9gknd 4851 2 2015 2015 CD cord-010119-t1x9gknd 4851 3 , , , cord-010119-t1x9gknd 4851 4 Basic basic JJ cord-010119-t1x9gknd 4851 5 trainees trainee NNS cord-010119-t1x9gknd 4851 6 at at IN cord-010119-t1x9gknd 4851 7 site site NN cord-010119-t1x9gknd 4851 8 A A NNP cord-010119-t1x9gknd 4851 9 were be VBD cord-010119-t1x9gknd 4851 10 scheduled schedule VBN cord-010119-t1x9gknd 4851 11 at at IN cord-010119-t1x9gknd 4851 12 day day NN cord-010119-t1x9gknd 4851 13 57 57 CD cord-010119-t1x9gknd 4851 14 of of IN cord-010119-t1x9gknd 4851 15 70 70 CD cord-010119-t1x9gknd 4851 16 . . . cord-010119-t1x9gknd 4852 1 In in IN cord-010119-t1x9gknd 4852 2 January January NNP cord-010119-t1x9gknd 4852 3 2016 2016 CD cord-010119-t1x9gknd 4852 4 , , , cord-010119-t1x9gknd 4852 5 the the DT cord-010119-t1x9gknd 4852 6 blood blood NN cord-010119-t1x9gknd 4852 7 drive drive NN cord-010119-t1x9gknd 4852 8 date date NN cord-010119-t1x9gknd 4852 9 changed change VBD cord-010119-t1x9gknd 4852 10 to to IN cord-010119-t1x9gknd 4852 11 day day NN cord-010119-t1x9gknd 4852 12 60 60 CD cord-010119-t1x9gknd 4852 13 of of IN cord-010119-t1x9gknd 4852 14 70 70 CD cord-010119-t1x9gknd 4852 15 . . . cord-010119-t1x9gknd 4853 1 The the DT cord-010119-t1x9gknd 4853 2 extra extra JJ cord-010119-t1x9gknd 4853 3 three three CD cord-010119-t1x9gknd 4853 4 days day NNS cord-010119-t1x9gknd 4853 5 in in IN cord-010119-t1x9gknd 4853 6 the the DT cord-010119-t1x9gknd 4853 7 Basic Basic NNP cord-010119-t1x9gknd 4853 8 Training Training NNP cord-010119-t1x9gknd 4853 9 atmosphere atmosphere NN cord-010119-t1x9gknd 4853 10 , , , cord-010119-t1x9gknd 4853 11 and and CC cord-010119-t1x9gknd 4853 12 its -PRON- PRP$ cord-010119-t1x9gknd 4853 13 associated associate VBN cord-010119-t1x9gknd 4853 14 diet diet NN cord-010119-t1x9gknd 4853 15 changes change NNS cord-010119-t1x9gknd 4853 16 and and CC cord-010119-t1x9gknd 4853 17 increased increase VBN cord-010119-t1x9gknd 4853 18 physical physical JJ cord-010119-t1x9gknd 4853 19 activity activity NN cord-010119-t1x9gknd 4853 20 may may MD cord-010119-t1x9gknd 4853 21 have have VB cord-010119-t1x9gknd 4853 22 had have VBN cord-010119-t1x9gknd 4853 23 an an DT cord-010119-t1x9gknd 4853 24 effect effect NN cord-010119-t1x9gknd 4853 25 on on IN cord-010119-t1x9gknd 4853 26 the the DT cord-010119-t1x9gknd 4853 27 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4853 28 levels level NNS cord-010119-t1x9gknd 4853 29 in in IN cord-010119-t1x9gknd 4853 30 that that DT cord-010119-t1x9gknd 4853 31 population population NN cord-010119-t1x9gknd 4853 32 . . . cord-010119-t1x9gknd 4854 1 At at IN cord-010119-t1x9gknd 4854 2 Basic basic JJ cord-010119-t1x9gknd 4854 3 Training Training NNP cord-010119-t1x9gknd 4854 4 Site site NN cord-010119-t1x9gknd 4854 5 B B NNP cord-010119-t1x9gknd 4854 6 , , , cord-010119-t1x9gknd 4854 7 the the DT cord-010119-t1x9gknd 4854 8 significant significant JJ cord-010119-t1x9gknd 4854 9 increase increase NN cord-010119-t1x9gknd 4854 10 from from IN cord-010119-t1x9gknd 4854 11 2015 2015 CD cord-010119-t1x9gknd 4854 12 to to IN cord-010119-t1x9gknd 4854 13 2016 2016 CD cord-010119-t1x9gknd 4854 14 of of IN cord-010119-t1x9gknd 4854 15 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4854 16 deferrals deferral NNS cord-010119-t1x9gknd 4854 17 can can MD cord-010119-t1x9gknd 4854 18 be be VB cord-010119-t1x9gknd 4854 19 attributed attribute VBN cord-010119-t1x9gknd 4854 20 to to IN cord-010119-t1x9gknd 4854 21 a a DT cord-010119-t1x9gknd 4854 22 larger large JJR cord-010119-t1x9gknd 4854 23 male male JJ cord-010119-t1x9gknd 4854 24 population population NN cord-010119-t1x9gknd 4854 25 presenting present VBG cord-010119-t1x9gknd 4854 26 at at IN cord-010119-t1x9gknd 4854 27 this this DT cord-010119-t1x9gknd 4854 28 site site NN cord-010119-t1x9gknd 4854 29 for for IN cord-010119-t1x9gknd 4854 30 Basic Basic NNP cord-010119-t1x9gknd 4854 31 Training Training NNP cord-010119-t1x9gknd 4854 32 . . . cord-010119-t1x9gknd 4855 1 Additionally additionally RB cord-010119-t1x9gknd 4855 2 , , , cord-010119-t1x9gknd 4855 3 the the DT cord-010119-t1x9gknd 4855 4 percentage percentage NN cord-010119-t1x9gknd 4855 5 of of IN cord-010119-t1x9gknd 4855 6 female female JJ cord-010119-t1x9gknd 4855 7 recruits recruit NNS cord-010119-t1x9gknd 4855 8 donating donate VBG cord-010119-t1x9gknd 4855 9 at at IN cord-010119-t1x9gknd 4855 10 the the DT cord-010119-t1x9gknd 4855 11 blood blood NN cord-010119-t1x9gknd 4855 12 drives drive NNS cord-010119-t1x9gknd 4855 13 decreased decrease VBD cord-010119-t1x9gknd 4855 14 in in IN cord-010119-t1x9gknd 4855 15 2016 2016 CD cord-010119-t1x9gknd 4855 16 . . . cord-010119-t1x9gknd 4856 1 These these DT cord-010119-t1x9gknd 4856 2 observations observation NNS cord-010119-t1x9gknd 4856 3 support support VBP cord-010119-t1x9gknd 4856 4 the the DT cord-010119-t1x9gknd 4856 5 hypothesis hypothesis NN cord-010119-t1x9gknd 4856 6 that that IN cord-010119-t1x9gknd 4856 7 the the DT cord-010119-t1x9gknd 4856 8 increase increase NN cord-010119-t1x9gknd 4856 9 in in IN cord-010119-t1x9gknd 4856 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4856 11 deferrals deferral NNS cord-010119-t1x9gknd 4856 12 in in IN cord-010119-t1x9gknd 4856 13 2016 2016 CD cord-010119-t1x9gknd 4856 14 resulted result VBD cord-010119-t1x9gknd 4856 15 from from IN cord-010119-t1x9gknd 4856 16 the the DT cord-010119-t1x9gknd 4856 17 implementation implementation NN cord-010119-t1x9gknd 4856 18 of of IN cord-010119-t1x9gknd 4856 19 the the DT cord-010119-t1x9gknd 4856 20 male male JJ cord-010119-t1x9gknd 4856 21 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4856 22 standard standard JJ cord-010119-t1x9gknd 4856 23 change change NN cord-010119-t1x9gknd 4856 24 from from IN cord-010119-t1x9gknd 4856 25 12.5 12.5 CD cord-010119-t1x9gknd 4856 26 to to IN cord-010119-t1x9gknd 4856 27 13.0 13.0 CD cord-010119-t1x9gknd 4856 28 g g NN cord-010119-t1x9gknd 4856 29 / / SYM cord-010119-t1x9gknd 4856 30 dl dl NN cord-010119-t1x9gknd 4856 31 at at IN cord-010119-t1x9gknd 4856 32 Basic Basic NNP cord-010119-t1x9gknd 4856 33 Training Training NNP cord-010119-t1x9gknd 4856 34 Site Site NNP cord-010119-t1x9gknd 4856 35 B. B. NNP cord-010119-t1x9gknd 4857 1 When when WRB cord-010119-t1x9gknd 4857 2 planning plan VBG cord-010119-t1x9gknd 4857 3 for for IN cord-010119-t1x9gknd 4857 4 blood blood NN cord-010119-t1x9gknd 4857 5 drives drive NNS cord-010119-t1x9gknd 4857 6 at at IN cord-010119-t1x9gknd 4857 7 basic basic JJ cord-010119-t1x9gknd 4857 8 training training NN cord-010119-t1x9gknd 4857 9 site site NN cord-010119-t1x9gknd 4857 10 B b NN cord-010119-t1x9gknd 4857 11 , , , cord-010119-t1x9gknd 4857 12 screening screening NN cord-010119-t1x9gknd 4857 13 of of IN cord-010119-t1x9gknd 4857 14 an an DT cord-010119-t1x9gknd 4857 15 additional additional JJ cord-010119-t1x9gknd 4857 16 24 24 CD cord-010119-t1x9gknd 4857 17 % % NN cord-010119-t1x9gknd 4857 18 of of IN cord-010119-t1x9gknd 4857 19 recruits recruit NNS cord-010119-t1x9gknd 4857 20 must must MD cord-010119-t1x9gknd 4857 21 be be VB cord-010119-t1x9gknd 4857 22 considered consider VBN cord-010119-t1x9gknd 4857 23 when when WRB cord-010119-t1x9gknd 4857 24 performing perform VBG cord-010119-t1x9gknd 4857 25 these these DT cord-010119-t1x9gknd 4857 26 blood blood NN cord-010119-t1x9gknd 4857 27 drives drive NNS cord-010119-t1x9gknd 4857 28 , , , cord-010119-t1x9gknd 4857 29 in in IN cord-010119-t1x9gknd 4857 30 order order NN cord-010119-t1x9gknd 4857 31 to to TO cord-010119-t1x9gknd 4857 32 meet meet VB cord-010119-t1x9gknd 4857 33 the the DT cord-010119-t1x9gknd 4857 34 same same JJ cord-010119-t1x9gknd 4857 35 collection collection NN cord-010119-t1x9gknd 4857 36 goals goal NNS cord-010119-t1x9gknd 4857 37 set set VBN cord-010119-t1x9gknd 4857 38 prior prior RB cord-010119-t1x9gknd 4857 39 the the DT cord-010119-t1x9gknd 4857 40 implementation implementation NN cord-010119-t1x9gknd 4857 41 of of IN cord-010119-t1x9gknd 4857 42 the the DT cord-010119-t1x9gknd 4857 43 change change NN cord-010119-t1x9gknd 4857 44 in in IN cord-010119-t1x9gknd 4857 45 the the DT cord-010119-t1x9gknd 4857 46 male male JJ cord-010119-t1x9gknd 4857 47 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4857 48 standard standard NN cord-010119-t1x9gknd 4857 49 . . . cord-010119-t1x9gknd 4858 1 Blood blood NN cord-010119-t1x9gknd 4858 2 Donation Donation NNP cord-010119-t1x9gknd 4858 3 in in IN cord-010119-t1x9gknd 4858 4 the the DT cord-010119-t1x9gknd 4858 5 Donor Donor NNP cord-010119-t1x9gknd 4858 6 with with IN cord-010119-t1x9gknd 4858 7 Spinal Spinal NNP cord-010119-t1x9gknd 4858 8 Cord Cord NNP cord-010119-t1x9gknd 4858 9 Injury injury NN cord-010119-t1x9gknd 4859 1 Joan Joan NNP cord-010119-t1x9gknd 4859 2 - - HYPH cord-010119-t1x9gknd 4859 3 Ramon Ramon NNP cord-010119-t1x9gknd 4859 4 Grífols Grífols NNP cord-010119-t1x9gknd 4859 5 * * NFP cord-010119-t1x9gknd 4859 6 1 1 CD cord-010119-t1x9gknd 4859 7 , , , cord-010119-t1x9gknd 4859 8 Eva Eva NNP cord-010119-t1x9gknd 4859 9 Alonso Alonso NNP cord-010119-t1x9gknd 4859 10 1 1 CD cord-010119-t1x9gknd 4859 11 , , , cord-010119-t1x9gknd 4859 12 Oscar Oscar NNP cord-010119-t1x9gknd 4859 13 Bascuñana Bascuñana NNP cord-010119-t1x9gknd 4859 14 1 1 CD cord-010119-t1x9gknd 4859 15 , , , cord-010119-t1x9gknd 4859 16 Monica Monica NNP cord-010119-t1x9gknd 4859 17 Romero Romero NNP cord-010119-t1x9gknd 4859 18 1 1 CD cord-010119-t1x9gknd 4859 19 , , , cord-010119-t1x9gknd 4859 20 Teresa Teresa NNP cord-010119-t1x9gknd 4859 21 Vich Vich NNP cord-010119-t1x9gknd 4859 22 1 1 CD cord-010119-t1x9gknd 4859 23 , , , cord-010119-t1x9gknd 4859 24 Elena Elena NNP cord-010119-t1x9gknd 4859 25 Castaño Castaño NNP cord-010119-t1x9gknd 4859 26 1 1 CD cord-010119-t1x9gknd 4859 27 , , , cord-010119-t1x9gknd 4859 28 Laura Laura NNP cord-010119-t1x9gknd 4859 29 Carbonell Carbonell NNP cord-010119-t1x9gknd 4859 30 1 1 CD cord-010119-t1x9gknd 4859 31 , , , cord-010119-t1x9gknd 4859 32 Eva Eva NNP cord-010119-t1x9gknd 4859 33 Palomas Palomas NNP cord-010119-t1x9gknd 4859 34 1 1 CD cord-010119-t1x9gknd 4859 35 , , , cord-010119-t1x9gknd 4859 36 Saray Saray NNP cord-010119-t1x9gknd 4859 37 Almerge Almerge NNP cord-010119-t1x9gknd 4859 38 1 1 CD cord-010119-t1x9gknd 4859 39 , , , cord-010119-t1x9gknd 4859 40 Francesc Francesc NNP cord-010119-t1x9gknd 4859 41 Carpio Carpio NNP cord-010119-t1x9gknd 4859 42 1 1 CD cord-010119-t1x9gknd 4859 43 and and CC cord-010119-t1x9gknd 4859 44 Xavier Xavier NNP cord-010119-t1x9gknd 4859 45 Curia Curia NNP cord-010119-t1x9gknd 4860 1 2 2 LS cord-010119-t1x9gknd 4860 2 . . . cord-010119-t1x9gknd 4861 1 1 1 LS cord-010119-t1x9gknd 4862 1 Banc Banc NNP cord-010119-t1x9gknd 4862 2 de de IN cord-010119-t1x9gknd 4862 3 Sang Sang NNP cord-010119-t1x9gknd 4862 4 i i NNP cord-010119-t1x9gknd 4862 5 Teixits Teixits NNP cord-010119-t1x9gknd 4862 6 , , , cord-010119-t1x9gknd 4862 7 2 2 CD cord-010119-t1x9gknd 4862 8 Institut Institut NNP cord-010119-t1x9gknd 4862 9 Guttmann Guttmann NNP cord-010119-t1x9gknd 4862 10 Background Background NNP cord-010119-t1x9gknd 4862 11 / / SYM cord-010119-t1x9gknd 4862 12 Case Case NNP cord-010119-t1x9gknd 4862 13 Studies Studies NNPS cord-010119-t1x9gknd 4862 14 : : : cord-010119-t1x9gknd 4862 15 Donation donation NN cord-010119-t1x9gknd 4862 16 of of IN cord-010119-t1x9gknd 4862 17 blood blood NN cord-010119-t1x9gknd 4862 18 components component NNS cord-010119-t1x9gknd 4862 19 ( ( -LRB- cord-010119-t1x9gknd 4862 20 BC BC NNP cord-010119-t1x9gknd 4862 21 ) ) -RRB- cord-010119-t1x9gknd 4862 22 in in IN cord-010119-t1x9gknd 4862 23 donors donor NNS cord-010119-t1x9gknd 4862 24 with with IN cord-010119-t1x9gknd 4862 25 spinal spinal JJ cord-010119-t1x9gknd 4862 26 cord cord NN cord-010119-t1x9gknd 4862 27 injuries injury NNS cord-010119-t1x9gknd 4862 28 ( ( -LRB- cord-010119-t1x9gknd 4862 29 SCI SCI NNP cord-010119-t1x9gknd 4862 30 ) ) -RRB- cord-010119-t1x9gknd 4862 31 is be VBZ cord-010119-t1x9gknd 4862 32 poorly poorly RB cord-010119-t1x9gknd 4862 33 studied study VBN cord-010119-t1x9gknd 4862 34 . . . cord-010119-t1x9gknd 4863 1 Paralysis paralysis NN cord-010119-t1x9gknd 4863 2 is be VBZ cord-010119-t1x9gknd 4863 3 a a DT cord-010119-t1x9gknd 4863 4 state state NN cord-010119-t1x9gknd 4863 5 , , , cord-010119-t1x9gknd 4863 6 not not RB cord-010119-t1x9gknd 4863 7 a a DT cord-010119-t1x9gknd 4863 8 disease disease NN cord-010119-t1x9gknd 4863 9 , , , cord-010119-t1x9gknd 4863 10 after after IN cord-010119-t1x9gknd 4863 11 a a DT cord-010119-t1x9gknd 4863 12 reasonable reasonable JJ cord-010119-t1x9gknd 4863 13 time time NN cord-010119-t1x9gknd 4863 14 since since IN cord-010119-t1x9gknd 4863 15 its -PRON- PRP$ cord-010119-t1x9gknd 4863 16 acquisition acquisition NN cord-010119-t1x9gknd 4863 17 these these DT cord-010119-t1x9gknd 4863 18 people people NNS cord-010119-t1x9gknd 4863 19 should should MD cord-010119-t1x9gknd 4863 20 not not RB cord-010119-t1x9gknd 4863 21 be be VB cord-010119-t1x9gknd 4863 22 differentiated differentiate VBN cord-010119-t1x9gknd 4863 23 from from IN cord-010119-t1x9gknd 4863 24 the the DT cord-010119-t1x9gknd 4863 25 rest rest NN cord-010119-t1x9gknd 4863 26 of of IN cord-010119-t1x9gknd 4863 27 the the DT cord-010119-t1x9gknd 4863 28 non non JJ cord-010119-t1x9gknd 4863 29 - - JJ cord-010119-t1x9gknd 4863 30 paralytic paralytic JJ cord-010119-t1x9gknd 4863 31 population population NN cord-010119-t1x9gknd 4863 32 in in IN cord-010119-t1x9gknd 4863 33 terms term NNS cord-010119-t1x9gknd 4863 34 of of IN cord-010119-t1x9gknd 4863 35 BC BC NNP cord-010119-t1x9gknd 4863 36 donation donation NN cord-010119-t1x9gknd 4863 37 . . . cord-010119-t1x9gknd 4864 1 The the DT cord-010119-t1x9gknd 4864 2 literature literature NN cord-010119-t1x9gknd 4864 3 reviews review NNS cord-010119-t1x9gknd 4864 4 of of IN cord-010119-t1x9gknd 4864 5 blood blood NN cord-010119-t1x9gknd 4864 6 donation donation NN cord-010119-t1x9gknd 4864 7 suitability suitability NN cord-010119-t1x9gknd 4864 8 criteria criterion NNS cord-010119-t1x9gknd 4864 9 among among IN cord-010119-t1x9gknd 4864 10 these these DT cord-010119-t1x9gknd 4864 11 people people NNS cord-010119-t1x9gknd 4864 12 are be VBP cord-010119-t1x9gknd 4864 13 scarce scarce JJ cord-010119-t1x9gknd 4864 14 and and CC cord-010119-t1x9gknd 4864 15 the the DT cord-010119-t1x9gknd 4864 16 vegetative vegetative JJ cord-010119-t1x9gknd 4864 17 lability lability NN cord-010119-t1x9gknd 4864 18 that that IN cord-010119-t1x9gknd 4864 19 they -PRON- PRP cord-010119-t1x9gknd 4864 20 may may MD cord-010119-t1x9gknd 4864 21 present present VB cord-010119-t1x9gknd 4864 22 depending depend VBG cord-010119-t1x9gknd 4864 23 on on IN cord-010119-t1x9gknd 4864 24 the the DT cord-010119-t1x9gknd 4864 25 type type NN cord-010119-t1x9gknd 4864 26 of of IN cord-010119-t1x9gknd 4864 27 their -PRON- PRP$ cord-010119-t1x9gknd 4864 28 SCI SCI NNP cord-010119-t1x9gknd 4865 1 it -PRON- PRP cord-010119-t1x9gknd 4865 2 's be VBZ cord-010119-t1x9gknd 4865 3 obvious obvious JJ cord-010119-t1x9gknd 4865 4 . . . cord-010119-t1x9gknd 4866 1 In in IN cord-010119-t1x9gknd 4866 2 daily daily JJ cord-010119-t1x9gknd 4866 3 practice practice NN cord-010119-t1x9gknd 4866 4 these these DT cord-010119-t1x9gknd 4866 5 potential potential JJ cord-010119-t1x9gknd 4866 6 donors donor NNS cord-010119-t1x9gknd 4866 7 are be VBP cord-010119-t1x9gknd 4866 8 often often RB cord-010119-t1x9gknd 4866 9 rejected reject VBN cord-010119-t1x9gknd 4866 10 for for IN cord-010119-t1x9gknd 4866 11 donation donation NN cord-010119-t1x9gknd 4866 12 with with IN cord-010119-t1x9gknd 4866 13 no no DT cord-010119-t1x9gknd 4866 14 specific specific JJ cord-010119-t1x9gknd 4866 15 criteria criterion NNS cord-010119-t1x9gknd 4866 16 related relate VBN cord-010119-t1x9gknd 4866 17 to to IN cord-010119-t1x9gknd 4866 18 their -PRON- PRP$ cord-010119-t1x9gknd 4866 19 SCI SCI NNP cord-010119-t1x9gknd 4866 20 . . . cord-010119-t1x9gknd 4867 1 The the DT cord-010119-t1x9gknd 4867 2 objectives objective NNS cord-010119-t1x9gknd 4867 3 of of IN cord-010119-t1x9gknd 4867 4 this this DT cord-010119-t1x9gknd 4867 5 study study NN cord-010119-t1x9gknd 4867 6 are be VBP cord-010119-t1x9gknd 4867 7 to to TO cord-010119-t1x9gknd 4867 8 establish establish VB cord-010119-t1x9gknd 4867 9 the the DT cord-010119-t1x9gknd 4867 10 selection selection NN cord-010119-t1x9gknd 4867 11 criteria criterion NNS cord-010119-t1x9gknd 4867 12 for for IN cord-010119-t1x9gknd 4867 13 BC BC NNP cord-010119-t1x9gknd 4867 14 donation donation NN cord-010119-t1x9gknd 4867 15 in in IN cord-010119-t1x9gknd 4867 16 people people NNS cord-010119-t1x9gknd 4867 17 with with IN cord-010119-t1x9gknd 4867 18 SCI SCI NNP cord-010119-t1x9gknd 4867 19 based base VBN cord-010119-t1x9gknd 4867 20 on on IN cord-010119-t1x9gknd 4867 21 medical medical JJ cord-010119-t1x9gknd 4867 22 criteria criterion NNS cord-010119-t1x9gknd 4867 23 . . . cord-010119-t1x9gknd 4868 1 To to TO cord-010119-t1x9gknd 4868 2 evaluate evaluate VB cord-010119-t1x9gknd 4868 3 the the DT cord-010119-t1x9gknd 4868 4 rate rate NN cord-010119-t1x9gknd 4868 5 of of IN cord-010119-t1x9gknd 4868 6 adverse adverse JJ cord-010119-t1x9gknd 4868 7 donation donation NN cord-010119-t1x9gknd 4868 8 blood blood NN cord-010119-t1x9gknd 4868 9 reactions reaction NNS cord-010119-t1x9gknd 4868 10 of of IN cord-010119-t1x9gknd 4868 11 these these DT cord-010119-t1x9gknd 4868 12 donors donor NNS cord-010119-t1x9gknd 4868 13 against against IN cord-010119-t1x9gknd 4868 14 a a DT cord-010119-t1x9gknd 4868 15 donor donor NN cord-010119-t1x9gknd 4868 16 control control NN cord-010119-t1x9gknd 4868 17 group group NN cord-010119-t1x9gknd 4868 18 without without IN cord-010119-t1x9gknd 4868 19 SCI SCI NNP cord-010119-t1x9gknd 4868 20 . . . cord-010119-t1x9gknd 4869 1 Study Study NNP cord-010119-t1x9gknd 4869 2 Design Design NNP cord-010119-t1x9gknd 4869 3 / / SYM cord-010119-t1x9gknd 4869 4 Method method NN cord-010119-t1x9gknd 4869 5 : : : cord-010119-t1x9gknd 4870 1 Our -PRON- PRP$ cord-010119-t1x9gknd 4870 2 organization organization NN cord-010119-t1x9gknd 4870 3 regularly regularly RB cord-010119-t1x9gknd 4870 4 organizes organize VBZ cord-010119-t1x9gknd 4870 5 a a DT cord-010119-t1x9gknd 4870 6 donation donation NN cord-010119-t1x9gknd 4870 7 campaign campaign NN cord-010119-t1x9gknd 4870 8 at at IN cord-010119-t1x9gknd 4870 9 a a DT cord-010119-t1x9gknd 4870 10 rehabilitation rehabilitation NN cord-010119-t1x9gknd 4870 11 center center NN cord-010119-t1x9gknd 4870 12 for for IN cord-010119-t1x9gknd 4870 13 patients patient NNS cord-010119-t1x9gknd 4870 14 with with IN cord-010119-t1x9gknd 4870 15 SCI SCI NNP cord-010119-t1x9gknd 4870 16 . . . cord-010119-t1x9gknd 4871 1 In in IN cord-010119-t1x9gknd 4871 2 this this DT cord-010119-t1x9gknd 4871 3 campaign campaign NN cord-010119-t1x9gknd 4871 4 some some DT cord-010119-t1x9gknd 4871 5 donors donor NNS cord-010119-t1x9gknd 4871 6 with with IN cord-010119-t1x9gknd 4871 7 SCI SCI NNP cord-010119-t1x9gknd 4871 8 as as IN cord-010119-t1x9gknd 4871 9 donors donor NNS cord-010119-t1x9gknd 4871 10 without without IN cord-010119-t1x9gknd 4871 11 ( ( -LRB- cord-010119-t1x9gknd 4871 12 professionals professional NNS cord-010119-t1x9gknd 4871 13 of of IN cord-010119-t1x9gknd 4871 14 the the DT cord-010119-t1x9gknd 4871 15 center center NN cord-010119-t1x9gknd 4871 16 , , , cord-010119-t1x9gknd 4871 17 relatives relative NNS cord-010119-t1x9gknd 4871 18 , , , cord-010119-t1x9gknd 4871 19 etc etc FW cord-010119-t1x9gknd 4871 20 . . . cord-010119-t1x9gknd 4871 21 ) ) -RRB- cord-010119-t1x9gknd 4871 22 donate donate VB cord-010119-t1x9gknd 4871 23 blood blood NN cord-010119-t1x9gknd 4871 24 . . . cord-010119-t1x9gknd 4872 1 From from IN cord-010119-t1x9gknd 4872 2 January January NNP cord-010119-t1x9gknd 4872 3 2015 2015 CD cord-010119-t1x9gknd 4872 4 to to IN cord-010119-t1x9gknd 4872 5 December December NNP cord-010119-t1x9gknd 4872 6 2016 2016 CD cord-010119-t1x9gknd 4872 7 we -PRON- PRP cord-010119-t1x9gknd 4872 8 analyzed analyze VBD cord-010119-t1x9gknd 4872 9 the the DT cord-010119-t1x9gknd 4872 10 number number NN cord-010119-t1x9gknd 4872 11 of of IN cord-010119-t1x9gknd 4872 12 donors donor NNS cord-010119-t1x9gknd 4872 13 who who WP cord-010119-t1x9gknd 4872 14 came come VBD cord-010119-t1x9gknd 4872 15 to to TO cord-010119-t1x9gknd 4872 16 give give VB cord-010119-t1x9gknd 4872 17 blood blood NN cord-010119-t1x9gknd 4872 18 , , , cord-010119-t1x9gknd 4872 19 the the DT cord-010119-t1x9gknd 4872 20 number number NN cord-010119-t1x9gknd 4872 21 and and CC cord-010119-t1x9gknd 4872 22 reasons reason NNS cord-010119-t1x9gknd 4872 23 for for IN cord-010119-t1x9gknd 4872 24 exclusion exclusion NN cord-010119-t1x9gknd 4872 25 of of IN cord-010119-t1x9gknd 4872 26 those those DT cord-010119-t1x9gknd 4872 27 who who WP cord-010119-t1x9gknd 4872 28 could could MD cord-010119-t1x9gknd 4872 29 not not RB cord-010119-t1x9gknd 4872 30 make make VB cord-010119-t1x9gknd 4872 31 the the DT cord-010119-t1x9gknd 4872 32 donation donation NN cord-010119-t1x9gknd 4872 33 , , , cord-010119-t1x9gknd 4872 34 whether whether IN cord-010119-t1x9gknd 4872 35 or or CC cord-010119-t1x9gknd 4872 36 not not RB cord-010119-t1x9gknd 4872 37 they -PRON- PRP cord-010119-t1x9gknd 4872 38 had have VBD cord-010119-t1x9gknd 4872 39 SCI SCI NNP cord-010119-t1x9gknd 4872 40 and and CC cord-010119-t1x9gknd 4872 41 number number NN cord-010119-t1x9gknd 4872 42 and and CC cord-010119-t1x9gknd 4872 43 typology typology NN cord-010119-t1x9gknd 4872 44 of of IN cord-010119-t1x9gknd 4872 45 adverse adverse JJ cord-010119-t1x9gknd 4872 46 reactions reaction NNS cord-010119-t1x9gknd 4872 47 to to IN cord-010119-t1x9gknd 4872 48 the the DT cord-010119-t1x9gknd 4872 49 donation donation NN cord-010119-t1x9gknd 4872 50 detected detect VBN cord-010119-t1x9gknd 4872 51 in in IN cord-010119-t1x9gknd 4872 52 both both DT cord-010119-t1x9gknd 4872 53 groups group NNS cord-010119-t1x9gknd 4872 54 . . . cord-010119-t1x9gknd 4873 1 Donors donor NNS cord-010119-t1x9gknd 4873 2 with with IN cord-010119-t1x9gknd 4873 3 SCI SCI NNP cord-010119-t1x9gknd 4873 4 higher high JJR cord-010119-t1x9gknd 4873 5 than than IN cord-010119-t1x9gknd 4873 6 T5 T5 NNP cord-010119-t1x9gknd 4873 7 due due IN cord-010119-t1x9gknd 4873 8 to to IN cord-010119-t1x9gknd 4873 9 the the DT cord-010119-t1x9gknd 4873 10 high high JJ cord-010119-t1x9gknd 4873 11 risk risk NN cord-010119-t1x9gknd 4873 12 of of IN cord-010119-t1x9gknd 4873 13 autonomic autonomic JJ cord-010119-t1x9gknd 4873 14 dysreflexia dysreflexia NN cord-010119-t1x9gknd 4873 15 were be VBD cord-010119-t1x9gknd 4873 16 excluded exclude VBN cord-010119-t1x9gknd 4873 17 for for IN cord-010119-t1x9gknd 4873 18 donation donation NN cord-010119-t1x9gknd 4873 19 . . . cord-010119-t1x9gknd 4874 1 Donors donor NNS cord-010119-t1x9gknd 4874 2 with with IN cord-010119-t1x9gknd 4874 3 SCI SCI NNP cord-010119-t1x9gknd 4874 4 below below IN cord-010119-t1x9gknd 4874 5 T5 T5 NNP cord-010119-t1x9gknd 4874 6 and and CC cord-010119-t1x9gknd 4874 7 less less JJR cord-010119-t1x9gknd 4874 8 than than IN cord-010119-t1x9gknd 4874 9 one one CD cord-010119-t1x9gknd 4874 10 year year NN cord-010119-t1x9gknd 4874 11 of of IN cord-010119-t1x9gknd 4874 12 evolution evolution NN cord-010119-t1x9gknd 4874 13 were be VBD cord-010119-t1x9gknd 4874 14 set set VBN cord-010119-t1x9gknd 4874 15 as as IN cord-010119-t1x9gknd 4874 16 temporary temporary JJ cord-010119-t1x9gknd 4874 17 exclusion exclusion NN cord-010119-t1x9gknd 4874 18 criteria criterion NNS cord-010119-t1x9gknd 4874 19 . . . cord-010119-t1x9gknd 4875 1 The the DT cord-010119-t1x9gknd 4875 2 presence presence NN cord-010119-t1x9gknd 4875 3 of of IN cord-010119-t1x9gknd 4875 4 neurogenic neurogenic JJ cord-010119-t1x9gknd 4875 5 bladder bladder NN cord-010119-t1x9gknd 4875 6 was be VBD cord-010119-t1x9gknd 4875 7 not not RB cord-010119-t1x9gknd 4875 8 considered consider VBN cord-010119-t1x9gknd 4875 9 a a DT cord-010119-t1x9gknd 4875 10 reason reason NN cord-010119-t1x9gknd 4875 11 for for IN cord-010119-t1x9gknd 4875 12 exclusion exclusion NN cord-010119-t1x9gknd 4875 13 . . . cord-010119-t1x9gknd 4876 1 Results result NNS cord-010119-t1x9gknd 4876 2 / / SYM cord-010119-t1x9gknd 4876 3 Finding finding NN cord-010119-t1x9gknd 4876 4 : : : cord-010119-t1x9gknd 4876 5 In in IN cord-010119-t1x9gknd 4876 6 the the DT cord-010119-t1x9gknd 4876 7 analyzed analyzed JJ cord-010119-t1x9gknd 4876 8 period period NN cord-010119-t1x9gknd 4876 9 , , , cord-010119-t1x9gknd 4876 10 219 219 CD cord-010119-t1x9gknd 4876 11 donors donor NNS cord-010119-t1x9gknd 4876 12 came come VBD cord-010119-t1x9gknd 4876 13 to to TO cord-010119-t1x9gknd 4876 14 give give VB cord-010119-t1x9gknd 4876 15 blood blood NN cord-010119-t1x9gknd 4876 16 , , , cord-010119-t1x9gknd 4876 17 of of IN cord-010119-t1x9gknd 4876 18 these these DT cord-010119-t1x9gknd 4876 19 , , , cord-010119-t1x9gknd 4876 20 15 15 CD cord-010119-t1x9gknd 4876 21 ( ( -LRB- cord-010119-t1x9gknd 4876 22 7 7 CD cord-010119-t1x9gknd 4876 23 % % NN cord-010119-t1x9gknd 4876 24 ) ) -RRB- cord-010119-t1x9gknd 4876 25 were be VBD cord-010119-t1x9gknd 4876 26 excluded exclude VBN cord-010119-t1x9gknd 4876 27 for for IN cord-010119-t1x9gknd 4876 28 donation donation NN cord-010119-t1x9gknd 4876 29 for for IN cord-010119-t1x9gknd 4876 30 various various JJ cord-010119-t1x9gknd 4876 31 reasons reason NNS cord-010119-t1x9gknd 4876 32 . . . cord-010119-t1x9gknd 4877 1 Two two CD cord-010119-t1x9gknd 4877 2 of of IN cord-010119-t1x9gknd 4877 3 the the DT cord-010119-t1x9gknd 4877 4 donors donor NNS cord-010119-t1x9gknd 4877 5 excluded exclude VBD cord-010119-t1x9gknd 4877 6 suffered suffer VBD cord-010119-t1x9gknd 4877 7 SCI SCI NNP cord-010119-t1x9gknd 4877 8 higher high JJR cord-010119-t1x9gknd 4877 9 than than IN cord-010119-t1x9gknd 4877 10 T5 T5 NNP cord-010119-t1x9gknd 4877 11 excluding exclude VBG cord-010119-t1x9gknd 4877 12 them -PRON- PRP cord-010119-t1x9gknd 4877 13 due due JJ cord-010119-t1x9gknd 4877 14 their -PRON- PRP$ cord-010119-t1x9gknd 4877 15 high high JJ cord-010119-t1x9gknd 4877 16 risk risk NN cord-010119-t1x9gknd 4877 17 of of IN cord-010119-t1x9gknd 4877 18 dysreflexia dysreflexia NN cord-010119-t1x9gknd 4877 19 . . . cord-010119-t1x9gknd 4878 1 Another another DT cord-010119-t1x9gknd 4878 2 one one CD cord-010119-t1x9gknd 4878 3 donor donor NN cord-010119-t1x9gknd 4878 4 excluded exclude VBD cord-010119-t1x9gknd 4878 5 suffered suffer VBD cord-010119-t1x9gknd 4878 6 SCI SCI NNP cord-010119-t1x9gknd 4878 7 lower lower RBR cord-010119-t1x9gknd 4878 8 than than IN cord-010119-t1x9gknd 4878 9 T5 T5 NNP cord-010119-t1x9gknd 4878 10 but but CC cord-010119-t1x9gknd 4878 11 his -PRON- PRP$ cord-010119-t1x9gknd 4878 12 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4878 13 levels level NNS cord-010119-t1x9gknd 4878 14 were be VBD cord-010119-t1x9gknd 4878 15 lower low JJR cord-010119-t1x9gknd 4878 16 than than IN cord-010119-t1x9gknd 4878 17 our -PRON- PRP$ cord-010119-t1x9gknd 4878 18 selection selection NN cord-010119-t1x9gknd 4878 19 criteria criterion NNS cord-010119-t1x9gknd 4878 20 . . . cord-010119-t1x9gknd 4879 1 Of of IN cord-010119-t1x9gknd 4879 2 the the DT cord-010119-t1x9gknd 4879 3 204 204 CD cord-010119-t1x9gknd 4879 4 donors donor NNS cord-010119-t1x9gknd 4879 5 selected select VBN cord-010119-t1x9gknd 4879 6 for for IN cord-010119-t1x9gknd 4879 7 donation donation NN cord-010119-t1x9gknd 4879 8 16 16 CD cord-010119-t1x9gknd 4879 9 ( ( -LRB- cord-010119-t1x9gknd 4879 10 7.8 7.8 CD cord-010119-t1x9gknd 4879 11 % % NN cord-010119-t1x9gknd 4879 12 ) ) -RRB- cord-010119-t1x9gknd 4879 13 had have VBD cord-010119-t1x9gknd 4879 14 SCI SCI NNP cord-010119-t1x9gknd 4879 15 lower low JJR cord-010119-t1x9gknd 4879 16 than than IN cord-010119-t1x9gknd 4879 17 T5 T5 NNP cord-010119-t1x9gknd 4879 18 and and CC cord-010119-t1x9gknd 4879 19 T6 T6 NNP cord-010119-t1x9gknd 4879 20 . . . cord-010119-t1x9gknd 4880 1 Adverse adverse JJ cord-010119-t1x9gknd 4880 2 reactions reaction NNS cord-010119-t1x9gknd 4880 3 to to IN cord-010119-t1x9gknd 4880 4 donation donation NN cord-010119-t1x9gknd 4880 5 ( ( -LRB- cord-010119-t1x9gknd 4880 6 1.4 1.4 CD cord-010119-t1x9gknd 4880 7 % % NN cord-010119-t1x9gknd 4880 8 ) ) -RRB- cord-010119-t1x9gknd 4880 9 were be VBD cord-010119-t1x9gknd 4880 10 recorded record VBN cord-010119-t1x9gknd 4880 11 in in IN cord-010119-t1x9gknd 4880 12 our -PRON- PRP$ cord-010119-t1x9gknd 4880 13 haemovigilance haemovigilance NN cord-010119-t1x9gknd 4880 14 program program NN cord-010119-t1x9gknd 4880 15 , , , cord-010119-t1x9gknd 4880 16 none none NN cord-010119-t1x9gknd 4880 17 of of IN cord-010119-t1x9gknd 4880 18 them -PRON- PRP cord-010119-t1x9gknd 4880 19 in in IN cord-010119-t1x9gknd 4880 20 donors donor NNS cord-010119-t1x9gknd 4880 21 with with IN cord-010119-t1x9gknd 4880 22 SCI SCI NNP cord-010119-t1x9gknd 4880 23 . . . cord-010119-t1x9gknd 4881 1 Conclusion conclusion NN cord-010119-t1x9gknd 4881 2 : : : cord-010119-t1x9gknd 4882 1 According accord VBG cord-010119-t1x9gknd 4882 2 to to IN cord-010119-t1x9gknd 4882 3 our -PRON- PRP$ cord-010119-t1x9gknd 4882 4 experience experience NN cord-010119-t1x9gknd 4882 5 donors donor NNS cord-010119-t1x9gknd 4882 6 with with IN cord-010119-t1x9gknd 4882 7 SCI SCI NNP cord-010119-t1x9gknd 4882 8 lower low JJR cord-010119-t1x9gknd 4882 9 than than IN cord-010119-t1x9gknd 4882 10 T5 T5 NNP cord-010119-t1x9gknd 4882 11 have have VBP cord-010119-t1x9gknd 4882 12 not not RB cord-010119-t1x9gknd 4882 13 had have VBN cord-010119-t1x9gknd 4882 14 any any DT cord-010119-t1x9gknd 4882 15 type type NN cord-010119-t1x9gknd 4882 16 of of IN cord-010119-t1x9gknd 4882 17 adverse adverse JJ cord-010119-t1x9gknd 4882 18 reaction reaction NN cord-010119-t1x9gknd 4882 19 to to IN cord-010119-t1x9gknd 4882 20 the the DT cord-010119-t1x9gknd 4882 21 blood blood NN cord-010119-t1x9gknd 4882 22 donation donation NN cord-010119-t1x9gknd 4882 23 . . . cord-010119-t1x9gknd 4883 1 There there EX cord-010119-t1x9gknd 4883 2 should should MD cord-010119-t1x9gknd 4883 3 be be VB cord-010119-t1x9gknd 4883 4 selection selection NN cord-010119-t1x9gknd 4883 5 / / SYM cord-010119-t1x9gknd 4883 6 exclusion exclusion NN cord-010119-t1x9gknd 4883 7 criteria criterion NNS cord-010119-t1x9gknd 4883 8 based base VBN cord-010119-t1x9gknd 4883 9 on on IN cord-010119-t1x9gknd 4883 10 the the DT cord-010119-t1x9gknd 4883 11 donor donor NN cord-010119-t1x9gknd 4883 12 's 's POS cord-010119-t1x9gknd 4883 13 paralytic paralytic JJ cord-010119-t1x9gknd 4883 14 conditions condition NNS cord-010119-t1x9gknd 4883 15 . . . cord-010119-t1x9gknd 4884 1 The the DT cord-010119-t1x9gknd 4884 2 vagal vagal JJ cord-010119-t1x9gknd 4884 3 syndrome syndrome NN cord-010119-t1x9gknd 4884 4 that that WDT cord-010119-t1x9gknd 4884 5 could could MD cord-010119-t1x9gknd 4884 6 appear appear VB cord-010119-t1x9gknd 4884 7 as as IN cord-010119-t1x9gknd 4884 8 a a DT cord-010119-t1x9gknd 4884 9 complication complication NN cord-010119-t1x9gknd 4884 10 to to IN cord-010119-t1x9gknd 4884 11 the the DT cord-010119-t1x9gknd 4884 12 donation donation NN cord-010119-t1x9gknd 4884 13 in in IN cord-010119-t1x9gknd 4884 14 these these DT cord-010119-t1x9gknd 4884 15 SCI SCI NNP cord-010119-t1x9gknd 4884 16 donors donor NNS cord-010119-t1x9gknd 4884 17 should should MD cord-010119-t1x9gknd 4884 18 be be VB cord-010119-t1x9gknd 4884 19 approached approach VBN cord-010119-t1x9gknd 4884 20 differently differently RB cord-010119-t1x9gknd 4884 21 to to IN cord-010119-t1x9gknd 4884 22 the the DT cord-010119-t1x9gknd 4884 23 usual usual JJ cord-010119-t1x9gknd 4884 24 protocols protocol NNS cord-010119-t1x9gknd 4884 25 that that WDT cord-010119-t1x9gknd 4884 26 we -PRON- PRP cord-010119-t1x9gknd 4884 27 use use VBP cord-010119-t1x9gknd 4884 28 . . . cord-010119-t1x9gknd 4885 1 Blood Blood NNP cord-010119-t1x9gknd 4885 2 Donor Donor NNP cord-010119-t1x9gknd 4885 3 Center Center NNP cord-010119-t1x9gknd 4885 4 's 's POS cord-010119-t1x9gknd 4885 5 Experience experience NN cord-010119-t1x9gknd 4885 6 with with IN cord-010119-t1x9gknd 4885 7 Changing change VBG cord-010119-t1x9gknd 4885 8 from from IN cord-010119-t1x9gknd 4885 9 Manual Manual NNP cord-010119-t1x9gknd 4885 10 to to IN cord-010119-t1x9gknd 4885 11 Automated Automated NNP cord-010119-t1x9gknd 4885 12 Blood Blood NNP cord-010119-t1x9gknd 4885 13 Pressures Pressures NNPS cord-010119-t1x9gknd 4885 14 Kimberly Kimberly NNP cord-010119-t1x9gknd 4885 15 J J NNP cord-010119-t1x9gknd 4885 16 Duffy Duffy NNP cord-010119-t1x9gknd 4886 1 * * NFP cord-010119-t1x9gknd 4886 2 , , , cord-010119-t1x9gknd 4886 3 Sandra Sandra NNP cord-010119-t1x9gknd 4886 4 Bryant Bryant NNP cord-010119-t1x9gknd 4886 5 , , , cord-010119-t1x9gknd 4886 6 Audrey Audrey NNP cord-010119-t1x9gknd 4886 7 E E NNP cord-010119-t1x9gknd 4886 8 Traun Traun NNP cord-010119-t1x9gknd 4886 9 , , , cord-010119-t1x9gknd 4886 10 Kristine Kristine NNP cord-010119-t1x9gknd 4886 11 I -PRON- PRP cord-010119-t1x9gknd 4886 12 Borth Borth NNP cord-010119-t1x9gknd 4886 13 , , , cord-010119-t1x9gknd 4886 14 Mary Mary NNP cord-010119-t1x9gknd 4886 15 M M NNP cord-010119-t1x9gknd 4886 16 Benike Benike NNP cord-010119-t1x9gknd 4886 17 , , , cord-010119-t1x9gknd 4886 18 James James NNP cord-010119-t1x9gknd 4886 19 R R NNP cord-010119-t1x9gknd 4886 20 Stubbs Stubbs NNP cord-010119-t1x9gknd 4886 21 and and CC cord-010119-t1x9gknd 4886 22 Justin Justin NNP cord-010119-t1x9gknd 4886 23 D D NNP cord-010119-t1x9gknd 4886 24 Kreuter Kreuter NNP cord-010119-t1x9gknd 4886 25 . . . cord-010119-t1x9gknd 4887 1 Mayo Mayo NNP cord-010119-t1x9gknd 4887 2 Clinic Clinic NNP cord-010119-t1x9gknd 4887 3 Background Background NNP cord-010119-t1x9gknd 4887 4 / / SYM cord-010119-t1x9gknd 4887 5 Case Case NNP cord-010119-t1x9gknd 4887 6 Studies Studies NNPS cord-010119-t1x9gknd 4887 7 : : : cord-010119-t1x9gknd 4887 8 Blood blood NN cord-010119-t1x9gknd 4887 9 pressure pressure NN cord-010119-t1x9gknd 4887 10 ( ( -LRB- cord-010119-t1x9gknd 4887 11 BP BP NNP cord-010119-t1x9gknd 4887 12 ) ) -RRB- cord-010119-t1x9gknd 4887 13 is be VBZ cord-010119-t1x9gknd 4887 14 important important JJ cord-010119-t1x9gknd 4887 15 for for IN cord-010119-t1x9gknd 4887 16 determining determine VBG cord-010119-t1x9gknd 4887 17 the the DT cord-010119-t1x9gknd 4887 18 health health NN cord-010119-t1x9gknd 4887 19 and and CC cord-010119-t1x9gknd 4887 20 suitability suitability NN cord-010119-t1x9gknd 4887 21 of of IN cord-010119-t1x9gknd 4887 22 blood blood NN cord-010119-t1x9gknd 4887 23 donors donor NNS cord-010119-t1x9gknd 4887 24 . . . cord-010119-t1x9gknd 4888 1 The the DT cord-010119-t1x9gknd 4888 2 manual manual JJ cord-010119-t1x9gknd 4888 3 method method NN cord-010119-t1x9gknd 4888 4 of of IN cord-010119-t1x9gknd 4888 5 reading read VBG cord-010119-t1x9gknd 4888 6 BP BP NNP cord-010119-t1x9gknd 4888 7 can can MD cord-010119-t1x9gknd 4888 8 result result VB cord-010119-t1x9gknd 4888 9 in in IN cord-010119-t1x9gknd 4888 10 variability variability NN cord-010119-t1x9gknd 4888 11 due due IN cord-010119-t1x9gknd 4888 12 to to IN cord-010119-t1x9gknd 4888 13 minor minor JJ cord-010119-t1x9gknd 4888 14 variances variance NNS cord-010119-t1x9gknd 4888 15 in in IN cord-010119-t1x9gknd 4888 16 the the DT cord-010119-t1x9gknd 4888 17 way way NN cord-010119-t1x9gknd 4888 18 staff staff NN cord-010119-t1x9gknd 4888 19 perform perform VBP cord-010119-t1x9gknd 4888 20 the the DT cord-010119-t1x9gknd 4888 21 manual manual JJ cord-010119-t1x9gknd 4888 22 procedure procedure NN cord-010119-t1x9gknd 4888 23 . . . cord-010119-t1x9gknd 4889 1 Automated automated JJ cord-010119-t1x9gknd 4889 2 BP BP NNP cord-010119-t1x9gknd 4889 3 devices device NNS cord-010119-t1x9gknd 4889 4 are be VBP cord-010119-t1x9gknd 4889 5 able able JJ cord-010119-t1x9gknd 4889 6 to to TO cord-010119-t1x9gknd 4889 7 reduce reduce VB cord-010119-t1x9gknd 4889 8 the the DT cord-010119-t1x9gknd 4889 9 variability variability NN cord-010119-t1x9gknd 4889 10 in in IN cord-010119-t1x9gknd 4889 11 BP BP NNP cord-010119-t1x9gknd 4889 12 determination determination NN cord-010119-t1x9gknd 4889 13 . . . cord-010119-t1x9gknd 4890 1 In in IN cord-010119-t1x9gknd 4890 2 December December NNP cord-010119-t1x9gknd 4890 3 of of IN cord-010119-t1x9gknd 4890 4 2013 2013 CD cord-010119-t1x9gknd 4890 5 , , , cord-010119-t1x9gknd 4890 6 automated automate VBN cord-010119-t1x9gknd 4890 7 BP BP NNP cord-010119-t1x9gknd 4890 8 devices device NNS cord-010119-t1x9gknd 4890 9 were be VBD cord-010119-t1x9gknd 4890 10 validated validate VBN cord-010119-t1x9gknd 4890 11 and and CC cord-010119-t1x9gknd 4890 12 replaced replace VBD cord-010119-t1x9gknd 4890 13 the the DT cord-010119-t1x9gknd 4890 14 manual manual JJ cord-010119-t1x9gknd 4890 15 BP BP NNP cord-010119-t1x9gknd 4890 16 method method NN cord-010119-t1x9gknd 4890 17 in in IN cord-010119-t1x9gknd 4890 18 our -PRON- PRP$ cord-010119-t1x9gknd 4890 19 blood blood NN cord-010119-t1x9gknd 4890 20 donor donor NN cord-010119-t1x9gknd 4890 21 center center NN cord-010119-t1x9gknd 4890 22 . . . cord-010119-t1x9gknd 4891 1 The the DT cord-010119-t1x9gknd 4891 2 objective objective NN cord-010119-t1x9gknd 4891 3 of of IN cord-010119-t1x9gknd 4891 4 this this DT cord-010119-t1x9gknd 4891 5 retrospective retrospective JJ cord-010119-t1x9gknd 4891 6 study study NN cord-010119-t1x9gknd 4891 7 is be VBZ cord-010119-t1x9gknd 4891 8 to to TO cord-010119-t1x9gknd 4891 9 determine determine VB cord-010119-t1x9gknd 4891 10 if if IN cord-010119-t1x9gknd 4891 11 the the DT cord-010119-t1x9gknd 4891 12 change change NN cord-010119-t1x9gknd 4891 13 from from IN cord-010119-t1x9gknd 4891 14 a a DT cord-010119-t1x9gknd 4891 15 manual manual NN cord-010119-t1x9gknd 4891 16 to to IN cord-010119-t1x9gknd 4891 17 an an DT cord-010119-t1x9gknd 4891 18 automated automate VBN cord-010119-t1x9gknd 4891 19 BP BP NNP cord-010119-t1x9gknd 4891 20 process process NN cord-010119-t1x9gknd 4891 21 has have VBZ cord-010119-t1x9gknd 4891 22 impacted impact VBN cord-010119-t1x9gknd 4891 23 the the DT cord-010119-t1x9gknd 4891 24 average average JJ cord-010119-t1x9gknd 4891 25 systolic systolic JJ cord-010119-t1x9gknd 4891 26 and and CC cord-010119-t1x9gknd 4891 27 diastolic diastolic JJ cord-010119-t1x9gknd 4891 28 pressures pressure NNS cord-010119-t1x9gknd 4891 29 and and CC cord-010119-t1x9gknd 4891 30 , , , cord-010119-t1x9gknd 4891 31 additionally additionally RB cord-010119-t1x9gknd 4891 32 , , , cord-010119-t1x9gknd 4891 33 if if IN cord-010119-t1x9gknd 4891 34 a a DT cord-010119-t1x9gknd 4891 35 differences difference NNS cord-010119-t1x9gknd 4891 36 in in IN cord-010119-t1x9gknd 4891 37 the the DT cord-010119-t1x9gknd 4891 38 deferral deferral NN cord-010119-t1x9gknd 4891 39 and and CC cord-010119-t1x9gknd 4891 40 reaction reaction NN cord-010119-t1x9gknd 4891 41 rate rate NN cord-010119-t1x9gknd 4891 42 can can MD cord-010119-t1x9gknd 4891 43 be be VB cord-010119-t1x9gknd 4891 44 observed observe VBN cord-010119-t1x9gknd 4891 45 . . . cord-010119-t1x9gknd 4892 1 Study Study NNP cord-010119-t1x9gknd 4892 2 Design Design NNP cord-010119-t1x9gknd 4892 3 / / SYM cord-010119-t1x9gknd 4892 4 Methods method NNS cord-010119-t1x9gknd 4892 5 : : : cord-010119-t1x9gknd 4893 1 Data datum NNS cord-010119-t1x9gknd 4893 2 for for IN cord-010119-t1x9gknd 4893 3 the the DT cord-010119-t1x9gknd 4893 4 manual manual JJ cord-010119-t1x9gknd 4893 5 BP BP NNP cord-010119-t1x9gknd 4893 6 process process NN cord-010119-t1x9gknd 4893 7 was be VBD cord-010119-t1x9gknd 4893 8 accumulated accumulate VBN cord-010119-t1x9gknd 4893 9 for for IN cord-010119-t1x9gknd 4893 10 an an DT cord-010119-t1x9gknd 4893 11 11 11 CD cord-010119-t1x9gknd 4893 12 month month NN cord-010119-t1x9gknd 4893 13 period period NN cord-010119-t1x9gknd 4893 14 from from IN cord-010119-t1x9gknd 4893 15 January January NNP cord-010119-t1x9gknd 4893 16 2013 2013 CD cord-010119-t1x9gknd 4893 17 to to IN cord-010119-t1x9gknd 4893 18 November November NNP cord-010119-t1x9gknd 4893 19 2013 2013 CD cord-010119-t1x9gknd 4893 20 . . . cord-010119-t1x9gknd 4894 1 The the DT cord-010119-t1x9gknd 4894 2 same same JJ cord-010119-t1x9gknd 4894 3 information information NN cord-010119-t1x9gknd 4894 4 was be VBD cord-010119-t1x9gknd 4894 5 assembled assemble VBN cord-010119-t1x9gknd 4894 6 for for IN cord-010119-t1x9gknd 4894 7 the the DT cord-010119-t1x9gknd 4894 8 automated automate VBN cord-010119-t1x9gknd 4894 9 BP BP NNP cord-010119-t1x9gknd 4894 10 process process NN cord-010119-t1x9gknd 4894 11 for for IN cord-010119-t1x9gknd 4894 12 the the DT cord-010119-t1x9gknd 4894 13 11 11 CD cord-010119-t1x9gknd 4894 14 month month NN cord-010119-t1x9gknd 4894 15 period period NN cord-010119-t1x9gknd 4894 16 of of IN cord-010119-t1x9gknd 4894 17 January January NNP cord-010119-t1x9gknd 4894 18 2014 2014 CD cord-010119-t1x9gknd 4894 19 to to IN cord-010119-t1x9gknd 4894 20 November November NNP cord-010119-t1x9gknd 4894 21 2014 2014 CD cord-010119-t1x9gknd 4894 22 . . . cord-010119-t1x9gknd 4895 1 The the DT cord-010119-t1x9gknd 4895 2 automated automated JJ cord-010119-t1x9gknd 4895 3 BP BP NNP cord-010119-t1x9gknd 4895 4 process process NN cord-010119-t1x9gknd 4895 5 implemented implement VBN cord-010119-t1x9gknd 4895 6 in in IN cord-010119-t1x9gknd 4895 7 mid mid NNP cord-010119-t1x9gknd 4895 8 - - NNP cord-010119-t1x9gknd 4895 9 December December NNP cord-010119-t1x9gknd 4895 10 2013 2013 CD cord-010119-t1x9gknd 4895 11 ; ; : cord-010119-t1x9gknd 4895 12 so so RB cord-010119-t1x9gknd 4895 13 the the DT cord-010119-t1x9gknd 4895 14 December December NNP cord-010119-t1x9gknd 4895 15 data datum NNS cord-010119-t1x9gknd 4895 16 for for IN cord-010119-t1x9gknd 4895 17 both both DT cord-010119-t1x9gknd 4895 18 2013 2013 CD cord-010119-t1x9gknd 4895 19 and and CC cord-010119-t1x9gknd 4895 20 2014 2014 CD cord-010119-t1x9gknd 4895 21 has have VBZ cord-010119-t1x9gknd 4895 22 been be VBN cord-010119-t1x9gknd 4895 23 excluded exclude VBN cord-010119-t1x9gknd 4895 24 from from IN cord-010119-t1x9gknd 4895 25 the the DT cord-010119-t1x9gknd 4895 26 study study NN cord-010119-t1x9gknd 4895 27 . . . cord-010119-t1x9gknd 4896 1 BP BP NNP cord-010119-t1x9gknd 4896 2 , , , cord-010119-t1x9gknd 4896 3 BP BP NNP cord-010119-t1x9gknd 4896 4 deferrals deferral NNS cord-010119-t1x9gknd 4896 5 , , , cord-010119-t1x9gknd 4896 6 reactions reaction NNS cord-010119-t1x9gknd 4896 7 , , , cord-010119-t1x9gknd 4896 8 donor donor NN cord-010119-t1x9gknd 4896 9 weights weight NNS cord-010119-t1x9gknd 4896 10 and and CC cord-010119-t1x9gknd 4896 11 demographics demographic NNS cord-010119-t1x9gknd 4896 12 were be VBD cord-010119-t1x9gknd 4896 13 evaluated evaluate VBN cord-010119-t1x9gknd 4896 14 for for IN cord-010119-t1x9gknd 4896 15 each each DT cord-010119-t1x9gknd 4896 16 time time NN cord-010119-t1x9gknd 4896 17 period period NN cord-010119-t1x9gknd 4896 18 . . . cord-010119-t1x9gknd 4897 1 A a DT cord-010119-t1x9gknd 4897 2 donor donor NN cord-010119-t1x9gknd 4897 3 may may MD cord-010119-t1x9gknd 4897 4 be be VB cord-010119-t1x9gknd 4897 5 included include VBN cord-010119-t1x9gknd 4897 6 multiple multiple JJ cord-010119-t1x9gknd 4897 7 times time NNS cord-010119-t1x9gknd 4897 8 in in IN cord-010119-t1x9gknd 4897 9 each each DT cord-010119-t1x9gknd 4897 10 year year NN cord-010119-t1x9gknd 4897 11 and and CC cord-010119-t1x9gknd 4897 12 could could MD cord-010119-t1x9gknd 4897 13 be be VB cord-010119-t1x9gknd 4897 14 in in IN cord-010119-t1x9gknd 4897 15 both both DT cord-010119-t1x9gknd 4897 16 sets set NNS cord-010119-t1x9gknd 4897 17 of of IN cord-010119-t1x9gknd 4897 18 data datum NNS cord-010119-t1x9gknd 4897 19 . . . cord-010119-t1x9gknd 4898 1 Generalized generalized JJ cord-010119-t1x9gknd 4898 2 estimating estimating NN cord-010119-t1x9gknd 4898 3 equations equation NNS cord-010119-t1x9gknd 4898 4 were be VBD cord-010119-t1x9gknd 4898 5 used use VBN cord-010119-t1x9gknd 4898 6 to to TO cord-010119-t1x9gknd 4898 7 assess assess VB cord-010119-t1x9gknd 4898 8 differences difference NNS cord-010119-t1x9gknd 4898 9 between between IN cord-010119-t1x9gknd 4898 10 automated automated JJ cord-010119-t1x9gknd 4898 11 and and CC cord-010119-t1x9gknd 4898 12 manual manual JJ cord-010119-t1x9gknd 4898 13 BP BP NNP cord-010119-t1x9gknd 4898 14 with with IN cord-010119-t1x9gknd 4898 15 significance significance NN cord-010119-t1x9gknd 4898 16 defined define VBN cord-010119-t1x9gknd 4898 17 as as IN cord-010119-t1x9gknd 4898 18 p p NN cord-010119-t1x9gknd 4898 19 < < XX cord-010119-t1x9gknd 4898 20 0.05 0.05 CD cord-010119-t1x9gknd 4898 21 . . . cord-010119-t1x9gknd 4899 1 Results result NNS cord-010119-t1x9gknd 4899 2 / / SYM cord-010119-t1x9gknd 4899 3 Findings finding NNS cord-010119-t1x9gknd 4899 4 : : : cord-010119-t1x9gknd 4900 1 Significantly significantly RB cord-010119-t1x9gknd 4900 2 more more JJR cord-010119-t1x9gknd 4900 3 people people NNS cord-010119-t1x9gknd 4900 4 were be VBD cord-010119-t1x9gknd 4900 5 deferred defer VBN cord-010119-t1x9gknd 4900 6 using use VBG cord-010119-t1x9gknd 4900 7 automated automate VBN cord-010119-t1x9gknd 4900 8 BP BP NNP cord-010119-t1x9gknd 4900 9 compared compare VBN cord-010119-t1x9gknd 4900 10 to to IN cord-010119-t1x9gknd 4900 11 manual manual JJ cord-010119-t1x9gknd 4900 12 BP BP NNP cord-010119-t1x9gknd 4900 13 readings reading NNS cord-010119-t1x9gknd 4900 14 ( ( -LRB- cord-010119-t1x9gknd 4900 15 p50.006 p50.006 NNP cord-010119-t1x9gknd 4900 16 ) ) -RRB- cord-010119-t1x9gknd 4900 17 . . . cord-010119-t1x9gknd 4901 1 Both both DT cord-010119-t1x9gknd 4901 2 systolic systolic JJ cord-010119-t1x9gknd 4901 3 and and CC cord-010119-t1x9gknd 4901 4 diastolic diastolic JJ cord-010119-t1x9gknd 4901 5 BP BP NNP cord-010119-t1x9gknd 4901 6 measured measure VBD cord-010119-t1x9gknd 4901 7 significantly significantly RB cord-010119-t1x9gknd 4901 8 higher higher RBR cord-010119-t1x9gknd 4901 9 by by IN cord-010119-t1x9gknd 4901 10 automated automate VBN cord-010119-t1x9gknd 4901 11 BP BP NNP cord-010119-t1x9gknd 4901 12 method method NN cord-010119-t1x9gknd 4901 13 than than IN cord-010119-t1x9gknd 4901 14 by by IN cord-010119-t1x9gknd 4901 15 manual manual JJ cord-010119-t1x9gknd 4901 16 method method NN cord-010119-t1x9gknd 4901 17 . . . cord-010119-t1x9gknd 4902 1 Although although IN cord-010119-t1x9gknd 4902 2 donors donor NNS cord-010119-t1x9gknd 4902 3 in in IN cord-010119-t1x9gknd 4902 4 the the DT cord-010119-t1x9gknd 4902 5 automated automate VBN cord-010119-t1x9gknd 4902 6 BP BP NNP cord-010119-t1x9gknd 4902 7 group group NN cord-010119-t1x9gknd 4902 8 experienced experience VBD cord-010119-t1x9gknd 4902 9 fewer few JJR cord-010119-t1x9gknd 4902 10 reactions reaction NNS cord-010119-t1x9gknd 4902 11 than than IN cord-010119-t1x9gknd 4902 12 those those DT cord-010119-t1x9gknd 4902 13 in in IN cord-010119-t1x9gknd 4902 14 the the DT cord-010119-t1x9gknd 4902 15 manual manual JJ cord-010119-t1x9gknd 4902 16 BP BP NNP cord-010119-t1x9gknd 4902 17 group group NN cord-010119-t1x9gknd 4902 18 , , , cord-010119-t1x9gknd 4902 19 the the DT cord-010119-t1x9gknd 4902 20 reduction reduction NN cord-010119-t1x9gknd 4902 21 was be VBD cord-010119-t1x9gknd 4902 22 not not RB cord-010119-t1x9gknd 4902 23 large large JJ cord-010119-t1x9gknd 4902 24 enough enough RB cord-010119-t1x9gknd 4902 25 to to TO cord-010119-t1x9gknd 4902 26 reach reach VB cord-010119-t1x9gknd 4902 27 statistical statistical JJ cord-010119-t1x9gknd 4902 28 significance significance NN cord-010119-t1x9gknd 4902 29 . . . cord-010119-t1x9gknd 4903 1 Even even RB cord-010119-t1x9gknd 4903 2 after after IN cord-010119-t1x9gknd 4903 3 adjusting adjust VBG cord-010119-t1x9gknd 4903 4 for for IN cord-010119-t1x9gknd 4903 5 gender gender NN cord-010119-t1x9gknd 4903 6 , , , cord-010119-t1x9gknd 4903 7 weight weight NN cord-010119-t1x9gknd 4903 8 and and CC cord-010119-t1x9gknd 4903 9 age age NN cord-010119-t1x9gknd 4903 10 at at IN cord-010119-t1x9gknd 4903 11 donation donation NN cord-010119-t1x9gknd 4903 12 , , , cord-010119-t1x9gknd 4903 13 BP BP NNP cord-010119-t1x9gknd 4903 14 deferrals deferral NNS cord-010119-t1x9gknd 4903 15 , , , cord-010119-t1x9gknd 4903 16 systolic systolic JJ cord-010119-t1x9gknd 4903 17 and and CC cord-010119-t1x9gknd 4903 18 diastolic diastolic JJ cord-010119-t1x9gknd 4903 19 BPs bp NNS cord-010119-t1x9gknd 4903 20 all all DT cord-010119-t1x9gknd 4903 21 remained remain VBD cord-010119-t1x9gknd 4903 22 significantly significantly RB cord-010119-t1x9gknd 4903 23 higher higher RBR cord-010119-t1x9gknd 4903 24 ( ( -LRB- cord-010119-t1x9gknd 4903 25 all all DT cord-010119-t1x9gknd 4903 26 p p NN cord-010119-t1x9gknd 4903 27 < < XX cord-010119-t1x9gknd 4903 28 0.03 0.03 CD cord-010119-t1x9gknd 4903 29 ) ) -RRB- cord-010119-t1x9gknd 4903 30 with with IN cord-010119-t1x9gknd 4903 31 the the DT cord-010119-t1x9gknd 4903 32 automated automate VBN cord-010119-t1x9gknd 4903 33 BP BP NNP cord-010119-t1x9gknd 4904 1 while while IN cord-010119-t1x9gknd 4904 2 and and CC cord-010119-t1x9gknd 4904 3 reactions reaction NNS cord-010119-t1x9gknd 4904 4 remained remain VBD cord-010119-t1x9gknd 4904 5 non non RB cord-010119-t1x9gknd 4904 6 - - JJ cord-010119-t1x9gknd 4904 7 significantly significantly RB cord-010119-t1x9gknd 4904 8 lower low JJR cord-010119-t1x9gknd 4904 9 ( ( -LRB- cord-010119-t1x9gknd 4904 10 p p NN cord-010119-t1x9gknd 4904 11 5 5 CD cord-010119-t1x9gknd 4904 12 0.086 0.086 CD cord-010119-t1x9gknd 4904 13 ) ) -RRB- cord-010119-t1x9gknd 4904 14 . . . cord-010119-t1x9gknd 4905 1 Conclusion conclusion NN cord-010119-t1x9gknd 4905 2 : : : cord-010119-t1x9gknd 4906 1 Automated automated JJ cord-010119-t1x9gknd 4906 2 BP BP NNP cord-010119-t1x9gknd 4906 3 devices device NNS cord-010119-t1x9gknd 4906 4 have have VBP cord-010119-t1x9gknd 4906 5 improved improve VBN cord-010119-t1x9gknd 4906 6 convenience convenience NN cord-010119-t1x9gknd 4906 7 for for IN cord-010119-t1x9gknd 4906 8 both both DT cord-010119-t1x9gknd 4906 9 staff staff NN cord-010119-t1x9gknd 4906 10 and and CC cord-010119-t1x9gknd 4906 11 donors donor NNS cord-010119-t1x9gknd 4906 12 . . . cord-010119-t1x9gknd 4907 1 With with IN cord-010119-t1x9gknd 4907 2 a a DT cord-010119-t1x9gknd 4907 3 statistically statistically RB cord-010119-t1x9gknd 4907 4 significant significant JJ cord-010119-t1x9gknd 4907 5 increase increase NN cord-010119-t1x9gknd 4907 6 in in IN cord-010119-t1x9gknd 4907 7 deferrals deferral NNS cord-010119-t1x9gknd 4907 8 and and CC cord-010119-t1x9gknd 4907 9 marginal marginal JJ cord-010119-t1x9gknd 4907 10 decrease decrease NN cord-010119-t1x9gknd 4907 11 in in IN cord-010119-t1x9gknd 4907 12 reactions reaction NNS cord-010119-t1x9gknd 4907 13 , , , cord-010119-t1x9gknd 4907 14 the the DT cord-010119-t1x9gknd 4907 15 use use NN cord-010119-t1x9gknd 4907 16 of of IN cord-010119-t1x9gknd 4907 17 automated automate VBN cord-010119-t1x9gknd 4907 18 BP BP NNP cord-010119-t1x9gknd 4907 19 devices device NNS cord-010119-t1x9gknd 4907 20 may may MD cord-010119-t1x9gknd 4907 21 play play VB cord-010119-t1x9gknd 4907 22 a a DT cord-010119-t1x9gknd 4907 23 minor minor JJ cord-010119-t1x9gknd 4907 24 role role NN cord-010119-t1x9gknd 4907 25 in in IN cord-010119-t1x9gknd 4907 26 the the DT cord-010119-t1x9gknd 4907 27 safety safety NN cord-010119-t1x9gknd 4907 28 of of IN cord-010119-t1x9gknd 4907 29 blood blood NN cord-010119-t1x9gknd 4907 30 donors donor NNS cord-010119-t1x9gknd 4907 31 . . . cord-010119-t1x9gknd 4908 1 For for IN cord-010119-t1x9gknd 4908 2 the the DT cord-010119-t1x9gknd 4908 3 purpose purpose NN cord-010119-t1x9gknd 4908 4 of of IN cord-010119-t1x9gknd 4908 5 this this DT cord-010119-t1x9gknd 4908 6 study study NN cord-010119-t1x9gknd 4908 7 , , , cord-010119-t1x9gknd 4908 8 only only RB cord-010119-t1x9gknd 4908 9 the the DT cord-010119-t1x9gknd 4908 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 4908 11 values value NNS cord-010119-t1x9gknd 4908 12 that that WDT cord-010119-t1x9gknd 4908 13 were be VBD cord-010119-t1x9gknd 4908 14 below below IN cord-010119-t1x9gknd 4908 15 12.5 12.5 CD cord-010119-t1x9gknd 4908 16 g g NNP cord-010119-t1x9gknd 4908 17 / / SYM cord-010119-t1x9gknd 4908 18 dl dl NNP cord-010119-t1x9gknd 4908 19 will will MD cord-010119-t1x9gknd 4908 20 be be VB cord-010119-t1x9gknd 4908 21 compared compare VBN cord-010119-t1x9gknd 4908 22 as as IN cord-010119-t1x9gknd 4908 23 a a DT cord-010119-t1x9gknd 4908 24 surrogate surrogate NN cord-010119-t1x9gknd 4908 25 for for IN cord-010119-t1x9gknd 4908 26 deferral deferral NN cord-010119-t1x9gknd 4908 27 . . . cord-010119-t1x9gknd 4909 1 To to TO cord-010119-t1x9gknd 4909 2 adjust adjust VB cord-010119-t1x9gknd 4909 3 for for IN cord-010119-t1x9gknd 4909 4 multiple multiple JJ cord-010119-t1x9gknd 4909 5 visits visit NNS cord-010119-t1x9gknd 4909 6 per per IN cord-010119-t1x9gknd 4909 7 donor donor NN cord-010119-t1x9gknd 4909 8 , , , cord-010119-t1x9gknd 4909 9 generalized generalize VBN cord-010119-t1x9gknd 4909 10 estimating estimating NN cord-010119-t1x9gknd 4909 11 equations equation NNS cord-010119-t1x9gknd 4909 12 were be VBD cord-010119-t1x9gknd 4909 13 used use VBN cord-010119-t1x9gknd 4909 14 to to TO cord-010119-t1x9gknd 4909 15 assess assess VB cord-010119-t1x9gknd 4909 16 significance significance NN cord-010119-t1x9gknd 4909 17 between between IN cord-010119-t1x9gknd 4909 18 lancet lancet NN cord-010119-t1x9gknd 4909 19 A a NN cord-010119-t1x9gknd 4909 20 and and CC cord-010119-t1x9gknd 4909 21 lancet lancet NN cord-010119-t1x9gknd 4909 22 B b NN cord-010119-t1x9gknd 4909 23 , , , cord-010119-t1x9gknd 4909 24 using use VBG cord-010119-t1x9gknd 4909 25 the the DT cord-010119-t1x9gknd 4909 26 appropriate appropriate JJ cord-010119-t1x9gknd 4909 27 distribution distribution NN cord-010119-t1x9gknd 4909 28 for for IN cord-010119-t1x9gknd 4909 29 the the DT cord-010119-t1x9gknd 4909 30 data data NN cord-010119-t1x9gknd 4909 31 type type NN cord-010119-t1x9gknd 4909 32 , , , cord-010119-t1x9gknd 4909 33 defining define VBG cord-010119-t1x9gknd 4909 34 statistical statistical JJ cord-010119-t1x9gknd 4909 35 significance significance NN cord-010119-t1x9gknd 4909 36 as as IN cord-010119-t1x9gknd 4909 37 p p NN cord-010119-t1x9gknd 4909 38 - - HYPH cord-010119-t1x9gknd 4909 39 value value NN cord-010119-t1x9gknd 4909 40 < < XX cord-010119-t1x9gknd 4909 41 0.05 0.05 CD cord-010119-t1x9gknd 4909 42 . . . cord-010119-t1x9gknd 4910 1 Results result NNS cord-010119-t1x9gknd 4910 2 / / SYM cord-010119-t1x9gknd 4910 3 Findings finding NNS cord-010119-t1x9gknd 4910 4 : : : cord-010119-t1x9gknd 4911 1 The the DT cord-010119-t1x9gknd 4911 2 average average JJ cord-010119-t1x9gknd 4911 3 hgb hgb NNP cord-010119-t1x9gknd 4911 4 was be VBD cord-010119-t1x9gknd 4911 5 slightly slightly RB cord-010119-t1x9gknd 4911 6 lower low JJR cord-010119-t1x9gknd 4911 7 with with IN cord-010119-t1x9gknd 4911 8 lancet lancet NN cord-010119-t1x9gknd 4911 9 B b NN cord-010119-t1x9gknd 4911 10 but but CC cord-010119-t1x9gknd 4911 11 there there EX cord-010119-t1x9gknd 4911 12 was be VBD cord-010119-t1x9gknd 4911 13 a a DT cord-010119-t1x9gknd 4911 14 larger large JJR cord-010119-t1x9gknd 4911 15 change change NN cord-010119-t1x9gknd 4911 16 with with IN cord-010119-t1x9gknd 4911 17 the the DT cord-010119-t1x9gknd 4911 18 number number NN cord-010119-t1x9gknd 4911 19 of of IN cord-010119-t1x9gknd 4911 20 donors donor NNS cord-010119-t1x9gknd 4911 21 under under IN cord-010119-t1x9gknd 4911 22 12.5 12.5 CD cord-010119-t1x9gknd 4911 23 . . . cord-010119-t1x9gknd 4912 1 Statistically statistically RB cord-010119-t1x9gknd 4912 2 more more JJR cord-010119-t1x9gknd 4912 3 visits visit NNS cord-010119-t1x9gknd 4912 4 with with IN cord-010119-t1x9gknd 4912 5 hgb hgb NNP cord-010119-t1x9gknd 4912 6 less less JJR cord-010119-t1x9gknd 4912 7 than than IN cord-010119-t1x9gknd 4912 8 12.5 12.5 CD cord-010119-t1x9gknd 4912 9 g g NNP cord-010119-t1x9gknd 4912 10 / / SYM cord-010119-t1x9gknd 4912 11 dl dl NNP cord-010119-t1x9gknd 4912 12 used use VBD cord-010119-t1x9gknd 4912 13 lancet lancet NNP cord-010119-t1x9gknd 4912 14 B B NNP cord-010119-t1x9gknd 4912 15 than than IN cord-010119-t1x9gknd 4912 16 lancet lancet NN cord-010119-t1x9gknd 4912 17 A. a. NN cord-010119-t1x9gknd 4913 1 Additionally additionally RB cord-010119-t1x9gknd 4913 2 , , , cord-010119-t1x9gknd 4913 3 fewer few JJR cord-010119-t1x9gknd 4913 4 first first JJ cord-010119-t1x9gknd 4913 5 time time NN cord-010119-t1x9gknd 4913 6 donors donor NNS cord-010119-t1x9gknd 4913 7 were be VBD cord-010119-t1x9gknd 4913 8 seen see VBN cord-010119-t1x9gknd 4913 9 during during IN cord-010119-t1x9gknd 4913 10 the the DT cord-010119-t1x9gknd 4913 11 lancet lancet NN cord-010119-t1x9gknd 4913 12 B B NNP cord-010119-t1x9gknd 4913 13 time time NN cord-010119-t1x9gknd 4913 14 than than IN cord-010119-t1x9gknd 4913 15 during during IN cord-010119-t1x9gknd 4913 16 the the DT cord-010119-t1x9gknd 4913 17 lancet lancet NN cord-010119-t1x9gknd 4913 18 A a DT cord-010119-t1x9gknd 4913 19 time time NN cord-010119-t1x9gknd 4913 20 . . . cord-010119-t1x9gknd 4914 1 After after IN cord-010119-t1x9gknd 4914 2 adjusting adjust VBG cord-010119-t1x9gknd 4914 3 for for IN cord-010119-t1x9gknd 4914 4 the the DT cord-010119-t1x9gknd 4914 5 effects effect NNS cord-010119-t1x9gknd 4914 6 of of IN cord-010119-t1x9gknd 4914 7 both both DT cord-010119-t1x9gknd 4914 8 gender gender NN cord-010119-t1x9gknd 4914 9 and and CC cord-010119-t1x9gknd 4914 10 first first JJ cord-010119-t1x9gknd 4914 11 - - HYPH cord-010119-t1x9gknd 4914 12 time time NN cord-010119-t1x9gknd 4914 13 donation donation NN cord-010119-t1x9gknd 4914 14 by by IN cord-010119-t1x9gknd 4914 15 using use VBG cord-010119-t1x9gknd 4914 16 logistic logistic JJ cord-010119-t1x9gknd 4914 17 regression regression NN cord-010119-t1x9gknd 4914 18 , , , cord-010119-t1x9gknd 4914 19 the the DT cord-010119-t1x9gknd 4914 20 risk risk NN cord-010119-t1x9gknd 4914 21 of of IN cord-010119-t1x9gknd 4914 22 hgb hgb NNP cord-010119-t1x9gknd 4914 23 under under IN cord-010119-t1x9gknd 4914 24 12.5 12.5 CD cord-010119-t1x9gknd 4914 25 was be VBD cord-010119-t1x9gknd 4914 26 16.5 16.5 CD cord-010119-t1x9gknd 4914 27 % % NN cord-010119-t1x9gknd 4914 28 higher high JJR cord-010119-t1x9gknd 4914 29 with with IN cord-010119-t1x9gknd 4914 30 lancet lancet NN cord-010119-t1x9gknd 4914 31 B b NN cord-010119-t1x9gknd 4914 32 than than IN cord-010119-t1x9gknd 4914 33 with with IN cord-010119-t1x9gknd 4914 34 lancet lancet NN cord-010119-t1x9gknd 4914 35 A. a. NN cord-010119-t1x9gknd 4914 36 Conclusion conclusion NN cord-010119-t1x9gknd 4914 37 : : : cord-010119-t1x9gknd 4915 1 Donor Donor NNP cord-010119-t1x9gknd 4915 2 's 's POS cord-010119-t1x9gknd 4915 3 hgb hgb NN cord-010119-t1x9gknd 4915 4 was be VBD cord-010119-t1x9gknd 4915 5 slightly slightly RB cord-010119-t1x9gknd 4915 6 lower low JJR cord-010119-t1x9gknd 4915 7 with with IN cord-010119-t1x9gknd 4915 8 lancet lancet NN cord-010119-t1x9gknd 4915 9 B b NN cord-010119-t1x9gknd 4915 10 than than IN cord-010119-t1x9gknd 4915 11 lancet lancet VBZ cord-010119-t1x9gknd 4915 12 A A NNP cord-010119-t1x9gknd 4915 13 , , , cord-010119-t1x9gknd 4915 14 but but CC cord-010119-t1x9gknd 4915 15 not not RB cord-010119-t1x9gknd 4915 16 clinically clinically RB cord-010119-t1x9gknd 4915 17 different different JJ cord-010119-t1x9gknd 4915 18 . . . cord-010119-t1x9gknd 4916 1 Slightly slightly RB cord-010119-t1x9gknd 4916 2 more more JJR cord-010119-t1x9gknd 4916 3 lancet lancet NN cord-010119-t1x9gknd 4917 1 Bs Bs NNP cord-010119-t1x9gknd 4917 2 were be VBD cord-010119-t1x9gknd 4917 3 used use VBN cord-010119-t1x9gknd 4917 4 per per IN cord-010119-t1x9gknd 4917 5 visit visit NN cord-010119-t1x9gknd 4917 6 than than IN cord-010119-t1x9gknd 4917 7 lancet lancet NNP cord-010119-t1x9gknd 4918 1 As as IN cord-010119-t1x9gknd 4918 2 . . . cord-010119-t1x9gknd 4919 1 In in IN cord-010119-t1x9gknd 4919 2 addition addition NN cord-010119-t1x9gknd 4919 3 , , , cord-010119-t1x9gknd 4919 4 more more JJR cord-010119-t1x9gknd 4919 5 hgb hgb NNP cord-010119-t1x9gknd 4919 6 deferrals deferral NNS cord-010119-t1x9gknd 4919 7 were be VBD cord-010119-t1x9gknd 4919 8 obtained obtain VBN cord-010119-t1x9gknd 4919 9 using use VBG cord-010119-t1x9gknd 4919 10 lancet lancet NNP cord-010119-t1x9gknd 4919 11 B b NN cord-010119-t1x9gknd 4919 12 than than IN cord-010119-t1x9gknd 4919 13 lancet lancet NN cord-010119-t1x9gknd 4919 14 A. a. NN cord-010119-t1x9gknd 4920 1 Even even RB cord-010119-t1x9gknd 4920 2 after after IN cord-010119-t1x9gknd 4920 3 adjusting adjust VBG cord-010119-t1x9gknd 4920 4 for for IN cord-010119-t1x9gknd 4920 5 the the DT cord-010119-t1x9gknd 4920 6 effects effect NNS cord-010119-t1x9gknd 4920 7 of of IN cord-010119-t1x9gknd 4920 8 gender gender NN cord-010119-t1x9gknd 4920 9 and and CC cord-010119-t1x9gknd 4920 10 repeat repeat VB cord-010119-t1x9gknd 4920 11 donors donor NNS cord-010119-t1x9gknd 4920 12 , , , cord-010119-t1x9gknd 4920 13 we -PRON- PRP cord-010119-t1x9gknd 4920 14 saw see VBD cord-010119-t1x9gknd 4920 15 more more JJR cord-010119-t1x9gknd 4920 16 potential potential JJ cord-010119-t1x9gknd 4920 17 deferrals deferral NNS cord-010119-t1x9gknd 4920 18 with with IN cord-010119-t1x9gknd 4920 19 lancet lancet NN cord-010119-t1x9gknd 4920 20 B b NN cord-010119-t1x9gknd 4920 21 than than IN cord-010119-t1x9gknd 4920 22 lancet lancet NN cord-010119-t1x9gknd 4920 23 A. a. NN cord-010119-t1x9gknd 4921 1 The the DT cord-010119-t1x9gknd 4921 2 slight slight JJ cord-010119-t1x9gknd 4921 3 difference difference NN cord-010119-t1x9gknd 4921 4 in in IN cord-010119-t1x9gknd 4921 5 the the DT cord-010119-t1x9gknd 4921 6 gauge gauge NN cord-010119-t1x9gknd 4921 7 of of IN cord-010119-t1x9gknd 4921 8 the the DT cord-010119-t1x9gknd 4921 9 lancet lancet NN cord-010119-t1x9gknd 4921 10 may may MD cord-010119-t1x9gknd 4921 11 have have VB cord-010119-t1x9gknd 4921 12 some some DT cord-010119-t1x9gknd 4921 13 association association NN cord-010119-t1x9gknd 4921 14 to to IN cord-010119-t1x9gknd 4921 15 free free RB cord-010119-t1x9gknd 4921 16 - - HYPH cord-010119-t1x9gknd 4921 17 flowing flowing JJ cord-010119-t1x9gknd 4921 18 amount amount NN cord-010119-t1x9gknd 4921 19 of of IN cord-010119-t1x9gknd 4921 20 blood blood NN cord-010119-t1x9gknd 4921 21 and and CC cord-010119-t1x9gknd 4921 22 may may MD cord-010119-t1x9gknd 4921 23 affect affect VB cord-010119-t1x9gknd 4921 24 hgb hgb NNP cord-010119-t1x9gknd 4921 25 levels level NNS cord-010119-t1x9gknd 4921 26 . . . cord-010119-t1x9gknd 4922 1 Prior prior RB cord-010119-t1x9gknd 4922 2 to to IN cord-010119-t1x9gknd 4922 3 implementing implement VBG cord-010119-t1x9gknd 4922 4 materials material NNS cord-010119-t1x9gknd 4922 5 at at IN cord-010119-t1x9gknd 4922 6 a a DT cord-010119-t1x9gknd 4922 7 lower low JJR cord-010119-t1x9gknd 4922 8 cost cost NN cord-010119-t1x9gknd 4922 9 , , , cord-010119-t1x9gknd 4922 10 an an DT cord-010119-t1x9gknd 4922 11 evaluation evaluation NN cord-010119-t1x9gknd 4922 12 of of IN cord-010119-t1x9gknd 4922 13 downstream downstream JJ cord-010119-t1x9gknd 4922 14 consequences consequence NNS cord-010119-t1x9gknd 4922 15 would would MD cord-010119-t1x9gknd 4922 16 be be VB cord-010119-t1x9gknd 4922 17 recommended recommend VBN cord-010119-t1x9gknd 4922 18 . . . cord-010119-t1x9gknd 4923 1 Blood blood NN cord-010119-t1x9gknd 4923 2 Donors Donors NNPS cord-010119-t1x9gknd 4923 3 ' ' POS cord-010119-t1x9gknd 4923 4 Acceptance Acceptance NNP cord-010119-t1x9gknd 4923 5 and and CC cord-010119-t1x9gknd 4923 6 Response response NN cord-010119-t1x9gknd 4923 7 Towards towards IN cord-010119-t1x9gknd 4923 8 Implementation Implementation NNP cord-010119-t1x9gknd 4923 9 of of IN cord-010119-t1x9gknd 4923 10 Automatic Automatic NNP cord-010119-t1x9gknd 4923 11 Appointment Appointment NNP cord-010119-t1x9gknd 4924 1 Booking book VBG cord-010119-t1x9gknd 4924 2 Yi Yi NNP cord-010119-t1x9gknd 4925 1 Lin Lin NNP cord-010119-t1x9gknd 4926 1 Ang Ang NNP cord-010119-t1x9gknd 4926 2 * * NFP cord-010119-t1x9gknd 4926 3 , , , cord-010119-t1x9gknd 4927 1 Ching Ching NNP cord-010119-t1x9gknd 4927 2 Lian Lian NNP cord-010119-t1x9gknd 4927 3 Toh Toh NNP cord-010119-t1x9gknd 4927 4 and and CC cord-010119-t1x9gknd 4927 5 William William NNP cord-010119-t1x9gknd 4927 6 Choon Choon NNP cord-010119-t1x9gknd 4927 7 Hong Hong NNP cord-010119-t1x9gknd 4927 8 Sim Sim NNP cord-010119-t1x9gknd 4927 9 . . . cord-010119-t1x9gknd 4928 1 Health Health NNP cord-010119-t1x9gknd 4928 2 Science Science NNP cord-010119-t1x9gknd 4928 3 Authority Authority NNP cord-010119-t1x9gknd 4928 4 Background Background NNP cord-010119-t1x9gknd 4928 5 / / SYM cord-010119-t1x9gknd 4928 6 Case Case NNP cord-010119-t1x9gknd 4928 7 Studies Studies NNPS cord-010119-t1x9gknd 4928 8 : : : cord-010119-t1x9gknd 4929 1 With with IN cord-010119-t1x9gknd 4929 2 surges surge NNS cord-010119-t1x9gknd 4929 3 in in IN cord-010119-t1x9gknd 4929 4 demand demand NN cord-010119-t1x9gknd 4929 5 for for IN cord-010119-t1x9gknd 4929 6 blood blood NN cord-010119-t1x9gknd 4929 7 due due IN cord-010119-t1x9gknd 4929 8 to to IN cord-010119-t1x9gknd 4929 9 an an DT cord-010119-t1x9gknd 4929 10 aging age VBG cord-010119-t1x9gknd 4929 11 population population NN cord-010119-t1x9gknd 4929 12 and and CC cord-010119-t1x9gknd 4929 13 more more JJR cord-010119-t1x9gknd 4929 14 hospitals hospital NNS cord-010119-t1x9gknd 4929 15 being be VBG cord-010119-t1x9gknd 4929 16 built build VBN cord-010119-t1x9gknd 4929 17 , , , cord-010119-t1x9gknd 4929 18 it -PRON- PRP cord-010119-t1x9gknd 4929 19 is be VBZ cord-010119-t1x9gknd 4929 20 becoming become VBG cord-010119-t1x9gknd 4929 21 increasingly increasingly RB cord-010119-t1x9gknd 4929 22 important important JJ cord-010119-t1x9gknd 4929 23 to to TO cord-010119-t1x9gknd 4929 24 be be VB cord-010119-t1x9gknd 4929 25 able able JJ cord-010119-t1x9gknd 4929 26 to to TO cord-010119-t1x9gknd 4929 27 ensure ensure VB cord-010119-t1x9gknd 4929 28 that that IN cord-010119-t1x9gknd 4929 29 donors donor NNS cord-010119-t1x9gknd 4929 30 return return VB cord-010119-t1x9gknd 4929 31 on on IN cord-010119-t1x9gknd 4929 32 a a DT cord-010119-t1x9gknd 4929 33 regular regular JJ cord-010119-t1x9gknd 4929 34 basis basis NN cord-010119-t1x9gknd 4929 35 to to TO cord-010119-t1x9gknd 4929 36 improve improve VB cord-010119-t1x9gknd 4929 37 blood blood NN cord-010119-t1x9gknd 4929 38 supply supply NN cord-010119-t1x9gknd 4929 39 and and CC cord-010119-t1x9gknd 4929 40 blood blood NN cord-010119-t1x9gknd 4929 41 stock stock NN cord-010119-t1x9gknd 4929 42 management management NN cord-010119-t1x9gknd 4929 43 . . . cord-010119-t1x9gknd 4930 1 Disliking dislike VBG cord-010119-t1x9gknd 4930 2 the the DT cord-010119-t1x9gknd 4930 3 obligation obligation NN cord-010119-t1x9gknd 4930 4 imposed impose VBN cord-010119-t1x9gknd 4930 5 by by IN cord-010119-t1x9gknd 4930 6 appointments appointment NNS cord-010119-t1x9gknd 4930 7 , , , cord-010119-t1x9gknd 4930 8 Singaporean singaporean JJ cord-010119-t1x9gknd 4930 9 donors donor NNS cord-010119-t1x9gknd 4930 10 generally generally RB cord-010119-t1x9gknd 4930 11 prefer prefer VBP cord-010119-t1x9gknd 4930 12 " " `` cord-010119-t1x9gknd 4930 13 walk walk NN cord-010119-t1x9gknd 4930 14 - - HYPH cord-010119-t1x9gknd 4930 15 ins in NNS cord-010119-t1x9gknd 4930 16 " " '' cord-010119-t1x9gknd 4930 17 as as IN cord-010119-t1x9gknd 4930 18 opposed oppose VBN cord-010119-t1x9gknd 4930 19 to to TO cord-010119-t1x9gknd 4930 20 appointment appointment VB cord-010119-t1x9gknd 4930 21 bookings booking NNS cord-010119-t1x9gknd 4930 22 . . . cord-010119-t1x9gknd 4931 1 Blood Blood NNP cord-010119-t1x9gknd 4931 2 Services Services NNPS cord-010119-t1x9gknd 4931 3 Group Group NNP cord-010119-t1x9gknd 4931 4 ( ( -LRB- cord-010119-t1x9gknd 4931 5 BSG BSG NNP cord-010119-t1x9gknd 4931 6 ) ) -RRB- cord-010119-t1x9gknd 4931 7 Singapore Singapore NNP cord-010119-t1x9gknd 4931 8 , , , cord-010119-t1x9gknd 4931 9 has have VBZ cord-010119-t1x9gknd 4931 10 made make VBN cord-010119-t1x9gknd 4931 11 a a DT cord-010119-t1x9gknd 4931 12 move move NN cord-010119-t1x9gknd 4931 13 to to TO cord-010119-t1x9gknd 4931 14 change change VB cord-010119-t1x9gknd 4931 15 donors donor NNS cord-010119-t1x9gknd 4931 16 ' ' POS cord-010119-t1x9gknd 4931 17 mindset mindset NN cord-010119-t1x9gknd 4931 18 by by IN cord-010119-t1x9gknd 4931 19 introducing introduce VBG cord-010119-t1x9gknd 4931 20 automatic automatic JJ cord-010119-t1x9gknd 4931 21 appointment appointment NN cord-010119-t1x9gknd 4931 22 scheduling scheduling NN cord-010119-t1x9gknd 4931 23 . . . cord-010119-t1x9gknd 4932 1 This this DT cord-010119-t1x9gknd 4932 2 paper paper NN cord-010119-t1x9gknd 4932 3 aims aim VBZ cord-010119-t1x9gknd 4932 4 to to TO cord-010119-t1x9gknd 4932 5 study study VB cord-010119-t1x9gknd 4932 6 donors donor NNS cord-010119-t1x9gknd 4932 7 ' ' POS cord-010119-t1x9gknd 4932 8 level level NN cord-010119-t1x9gknd 4932 9 of of IN cord-010119-t1x9gknd 4932 10 acceptance acceptance NN cord-010119-t1x9gknd 4932 11 towards towards IN cord-010119-t1x9gknd 4932 12 this this DT cord-010119-t1x9gknd 4932 13 initiative initiative NN cord-010119-t1x9gknd 4932 14 . . . cord-010119-t1x9gknd 4933 1 Study Study NNP cord-010119-t1x9gknd 4933 2 Design Design NNP cord-010119-t1x9gknd 4933 3 / / SYM cord-010119-t1x9gknd 4933 4 Method method NN cord-010119-t1x9gknd 4933 5 : : : cord-010119-t1x9gknd 4934 1 To to TO cord-010119-t1x9gknd 4934 2 determine determine VB cord-010119-t1x9gknd 4934 3 the the DT cord-010119-t1x9gknd 4934 4 donors donor NNS cord-010119-t1x9gknd 4934 5 ' ' POS cord-010119-t1x9gknd 4934 6 acceptance acceptance NN cord-010119-t1x9gknd 4934 7 rate rate NN cord-010119-t1x9gknd 4934 8 , , , cord-010119-t1x9gknd 4934 9 data datum NNS cord-010119-t1x9gknd 4934 10 was be VBD cord-010119-t1x9gknd 4934 11 collected collect VBN cord-010119-t1x9gknd 4934 12 from from IN cord-010119-t1x9gknd 4934 13 1 1 CD cord-010119-t1x9gknd 4934 14 January January NNP cord-010119-t1x9gknd 4934 15 to to IN cord-010119-t1x9gknd 4934 16 31 31 CD cord-010119-t1x9gknd 4934 17 March March NNP cord-010119-t1x9gknd 4934 18 2017 2017 CD cord-010119-t1x9gknd 4934 19 . . . cord-010119-t1x9gknd 4935 1 After after IN cord-010119-t1x9gknd 4935 2 completing complete VBG cord-010119-t1x9gknd 4935 3 their -PRON- PRP$ cord-010119-t1x9gknd 4935 4 donation donation NN cord-010119-t1x9gknd 4935 5 , , , cord-010119-t1x9gknd 4935 6 donors donor NNS cord-010119-t1x9gknd 4935 7 were be VBD cord-010119-t1x9gknd 4935 8 automatically automatically RB cord-010119-t1x9gknd 4935 9 given give VBN cord-010119-t1x9gknd 4935 10 the the DT cord-010119-t1x9gknd 4935 11 next next JJ cord-010119-t1x9gknd 4935 12 earliest early JJS cord-010119-t1x9gknd 4935 13 eligible eligible JJ cord-010119-t1x9gknd 4935 14 date date NN cord-010119-t1x9gknd 4935 15 for for IN cord-010119-t1x9gknd 4935 16 their -PRON- PRP$ cord-010119-t1x9gknd 4935 17 next next JJ cord-010119-t1x9gknd 4935 18 donation donation NN cord-010119-t1x9gknd 4935 19 . . . cord-010119-t1x9gknd 4936 1 Those those DT cord-010119-t1x9gknd 4936 2 who who WP cord-010119-t1x9gknd 4936 3 do do VBP cord-010119-t1x9gknd 4936 4 not not RB cord-010119-t1x9gknd 4936 5 wish wish VB cord-010119-t1x9gknd 4936 6 to to TO cord-010119-t1x9gknd 4936 7 accept accept VB cord-010119-t1x9gknd 4936 8 the the DT cord-010119-t1x9gknd 4936 9 recommended recommend VBN cord-010119-t1x9gknd 4936 10 appointment appointment NN cord-010119-t1x9gknd 4936 11 can can MD cord-010119-t1x9gknd 4936 12 either either CC cord-010119-t1x9gknd 4936 13 decline decline VB cord-010119-t1x9gknd 4936 14 this this DT cord-010119-t1x9gknd 4936 15 arrangement arrangement NN cord-010119-t1x9gknd 4936 16 or or CC cord-010119-t1x9gknd 4936 17 log log VB cord-010119-t1x9gknd 4936 18 into into IN cord-010119-t1x9gknd 4936 19 the the DT cord-010119-t1x9gknd 4936 20 blood blood NN cord-010119-t1x9gknd 4936 21 bank bank NN cord-010119-t1x9gknd 4936 22 's 's POS cord-010119-t1x9gknd 4936 23 donor donor NN cord-010119-t1x9gknd 4936 24 appointment appointment NN cord-010119-t1x9gknd 4936 25 booking booking NN cord-010119-t1x9gknd 4936 26 system system NN cord-010119-t1x9gknd 4936 27 ( ( -LRB- cord-010119-t1x9gknd 4936 28 Donor Donor NNP cord-010119-t1x9gknd 4936 29 - - HYPH cord-010119-t1x9gknd 4936 30 Care Care NNP cord-010119-t1x9gknd 4936 31 ) ) -RRB- cord-010119-t1x9gknd 4936 32 to to TO cord-010119-t1x9gknd 4936 33 make make VB cord-010119-t1x9gknd 4936 34 changes change NNS cord-010119-t1x9gknd 4936 35 to to IN cord-010119-t1x9gknd 4936 36 the the DT cord-010119-t1x9gknd 4936 37 appointment appointment NN cord-010119-t1x9gknd 4936 38 offered offer VBD cord-010119-t1x9gknd 4936 39 . . . cord-010119-t1x9gknd 4937 1 A a DT cord-010119-t1x9gknd 4937 2 reminder reminder NN cord-010119-t1x9gknd 4937 3 will will MD cord-010119-t1x9gknd 4937 4 be be VB cord-010119-t1x9gknd 4937 5 sent send VBN cord-010119-t1x9gknd 4937 6 to to IN cord-010119-t1x9gknd 4937 7 their -PRON- PRP$ cord-010119-t1x9gknd 4937 8 phone phone NN cord-010119-t1x9gknd 4937 9 via via IN cord-010119-t1x9gknd 4937 10 SMS SMS NNP cord-010119-t1x9gknd 4937 11 and/or and/or CC cord-010119-t1x9gknd 4937 12 email email VB cord-010119-t1x9gknd 4937 13 to to IN cord-010119-t1x9gknd 4937 14 their -PRON- PRP$ cord-010119-t1x9gknd 4937 15 account account NN cord-010119-t1x9gknd 4937 16 three three CD cord-010119-t1x9gknd 4937 17 days day NNS cord-010119-t1x9gknd 4937 18 before before IN cord-010119-t1x9gknd 4937 19 the the DT cord-010119-t1x9gknd 4937 20 appointment appointment NN cord-010119-t1x9gknd 4937 21 date date NN cord-010119-t1x9gknd 4937 22 . . . cord-010119-t1x9gknd 4938 1 Data datum NNS cord-010119-t1x9gknd 4938 2 was be VBD cord-010119-t1x9gknd 4938 3 collected collect VBN cord-010119-t1x9gknd 4938 4 from from IN cord-010119-t1x9gknd 4938 5 Donor Donor NNP cord-010119-t1x9gknd 4938 6 - - HYPH cord-010119-t1x9gknd 4938 7 Care Care NNP cord-010119-t1x9gknd 4938 8 and and CC cord-010119-t1x9gknd 4938 9 was be VBD cord-010119-t1x9gknd 4938 10 used use VBN cord-010119-t1x9gknd 4938 11 to to TO cord-010119-t1x9gknd 4938 12 measure measure VB cord-010119-t1x9gknd 4938 13 the the DT cord-010119-t1x9gknd 4938 14 number number NN cord-010119-t1x9gknd 4938 15 of of IN cord-010119-t1x9gknd 4938 16 appointments appointment NNS cord-010119-t1x9gknd 4938 17 made make VBN cord-010119-t1x9gknd 4938 18 and and CC cord-010119-t1x9gknd 4938 19 declined decline VBD cord-010119-t1x9gknd 4938 20 over over IN cord-010119-t1x9gknd 4938 21 the the DT cord-010119-t1x9gknd 4938 22 three three CD cord-010119-t1x9gknd 4938 23 months month NNS cord-010119-t1x9gknd 4938 24 period period NN cord-010119-t1x9gknd 4938 25 . . . cord-010119-t1x9gknd 4939 1 Donors donor NNS cord-010119-t1x9gknd 4939 2 who who WP cord-010119-t1x9gknd 4939 3 declined decline VBD cord-010119-t1x9gknd 4939 4 appointment appointment NN cord-010119-t1x9gknd 4939 5 scheduling scheduling NN cord-010119-t1x9gknd 4939 6 were be VBD cord-010119-t1x9gknd 4939 7 verbally verbally RB cord-010119-t1x9gknd 4939 8 interviewed interview VBN cord-010119-t1x9gknd 4939 9 for for IN cord-010119-t1x9gknd 4939 10 their -PRON- PRP$ cord-010119-t1x9gknd 4939 11 reasons reason NNS cord-010119-t1x9gknd 4939 12 . . . cord-010119-t1x9gknd 4940 1 Results result NNS cord-010119-t1x9gknd 4940 2 / / SYM cord-010119-t1x9gknd 4940 3 Finding finding NN cord-010119-t1x9gknd 4940 4 : : : cord-010119-t1x9gknd 4941 1 A a DT cord-010119-t1x9gknd 4941 2 total total NN cord-010119-t1x9gknd 4941 3 of of IN cord-010119-t1x9gknd 4941 4 6680 6680 CD cord-010119-t1x9gknd 4941 5 donors donor NNS cord-010119-t1x9gknd 4941 6 who who WP cord-010119-t1x9gknd 4941 7 has have VBZ cord-010119-t1x9gknd 4941 8 donated donate VBN cord-010119-t1x9gknd 4941 9 blood blood NN cord-010119-t1x9gknd 4941 10 in in IN cord-010119-t1x9gknd 4941 11 the the DT cord-010119-t1x9gknd 4941 12 blood blood NN cord-010119-t1x9gknd 4941 13 bank bank NN cord-010119-t1x9gknd 4941 14 's 's POS cord-010119-t1x9gknd 4941 15 main main JJ cord-010119-t1x9gknd 4941 16 branch branch NN cord-010119-t1x9gknd 4941 17 were be VBD cord-010119-t1x9gknd 4941 18 used use VBN cord-010119-t1x9gknd 4941 19 as as IN cord-010119-t1x9gknd 4941 20 the the DT cord-010119-t1x9gknd 4941 21 baseline baseline NN cord-010119-t1x9gknd 4941 22 for for IN cord-010119-t1x9gknd 4941 23 this this DT cord-010119-t1x9gknd 4941 24 study study NN cord-010119-t1x9gknd 4941 25 . . . cord-010119-t1x9gknd 4942 1 85 85 CD cord-010119-t1x9gknd 4942 2 % % NN cord-010119-t1x9gknd 4942 3 of of IN cord-010119-t1x9gknd 4942 4 donors donor NNS cord-010119-t1x9gknd 4942 5 ( ( -LRB- cord-010119-t1x9gknd 4942 6 N55678 N55678 NNP cord-010119-t1x9gknd 4942 7 ) ) -RRB- cord-010119-t1x9gknd 4942 8 accepted accept VBD cord-010119-t1x9gknd 4942 9 automatic automatic JJ cord-010119-t1x9gknd 4942 10 appointment appointment NN cord-010119-t1x9gknd 4942 11 booking booking NN cord-010119-t1x9gknd 4942 12 , , , cord-010119-t1x9gknd 4942 13 whereas whereas IN cord-010119-t1x9gknd 4942 14 some some DT cord-010119-t1x9gknd 4942 15 donors donor NNS cord-010119-t1x9gknd 4942 16 ( ( -LRB- cord-010119-t1x9gknd 4942 17 N51002 N51002 NNP cord-010119-t1x9gknd 4942 18 ) ) -RRB- cord-010119-t1x9gknd 4942 19 were be VBD cord-010119-t1x9gknd 4942 20 not not RB cord-010119-t1x9gknd 4942 21 comfortable comfortable JJ cord-010119-t1x9gknd 4942 22 with with IN cord-010119-t1x9gknd 4942 23 it -PRON- PRP cord-010119-t1x9gknd 4942 24 . . . cord-010119-t1x9gknd 4943 1 77 77 CD cord-010119-t1x9gknd 4943 2 % % NN cord-010119-t1x9gknd 4943 3 of of IN cord-010119-t1x9gknd 4943 4 those those DT cord-010119-t1x9gknd 4943 5 who who WP cord-010119-t1x9gknd 4943 6 declined decline VBD cord-010119-t1x9gknd 4943 7 still still RB cord-010119-t1x9gknd 4943 8 preferred prefer VBD cord-010119-t1x9gknd 4943 9 walk walk NN cord-010119-t1x9gknd 4943 10 - - HYPH cord-010119-t1x9gknd 4943 11 ins in NNS cord-010119-t1x9gknd 4943 12 ( ( -LRB- cord-010119-t1x9gknd 4943 13 N5771 N5771 NNP cord-010119-t1x9gknd 4943 14 ) ) -RRB- cord-010119-t1x9gknd 4943 15 based base VBN cord-010119-t1x9gknd 4943 16 on on IN cord-010119-t1x9gknd 4943 17 their -PRON- PRP$ cord-010119-t1x9gknd 4943 18 own own JJ cord-010119-t1x9gknd 4943 19 time time NN cord-010119-t1x9gknd 4943 20 schedule schedule NN cord-010119-t1x9gknd 4943 21 , , , cord-010119-t1x9gknd 4943 22 the the DT cord-010119-t1x9gknd 4943 23 rest rest NN cord-010119-t1x9gknd 4943 24 decided decide VBD cord-010119-t1x9gknd 4943 25 that that IN cord-010119-t1x9gknd 4943 26 variable variable JJ cord-010119-t1x9gknd 4943 27 situations situation NNS cord-010119-t1x9gknd 4943 28 ( ( -LRB- cord-010119-t1x9gknd 4943 29 N5112 N5112 NNP cord-010119-t1x9gknd 4943 30 ) ) -RRB- cord-010119-t1x9gknd 4943 31 , , , cord-010119-t1x9gknd 4943 32 donation donation NN cord-010119-t1x9gknd 4943 33 frequency frequency NN cord-010119-t1x9gknd 4943 34 ( ( -LRB- cord-010119-t1x9gknd 4943 35 N569 N569 -RRB- cord-010119-t1x9gknd 4943 36 ) ) -RRB- cord-010119-t1x9gknd 4943 37 and and CC cord-010119-t1x9gknd 4943 38 choice choice NN cord-010119-t1x9gknd 4943 39 of of IN cord-010119-t1x9gknd 4943 40 preferred preferred JJ cord-010119-t1x9gknd 4943 41 donation donation NN cord-010119-t1x9gknd 4943 42 locations location NNS cord-010119-t1x9gknd 4943 43 ( ( -LRB- cord-010119-t1x9gknd 4943 44 N550 N550 NNP cord-010119-t1x9gknd 4943 45 ) ) -RRB- cord-010119-t1x9gknd 4943 46 were be VBD cord-010119-t1x9gknd 4943 47 reasons reason NNS cord-010119-t1x9gknd 4943 48 for for IN cord-010119-t1x9gknd 4943 49 declining decline VBG cord-010119-t1x9gknd 4943 50 automatic automatic JJ cord-010119-t1x9gknd 4943 51 appointment appointment NN cord-010119-t1x9gknd 4943 52 booking booking NN cord-010119-t1x9gknd 4943 53 . . . cord-010119-t1x9gknd 4944 1 Prior prior JJ cord-010119-t1x9gknd 4944 2 implementation implementation NN cord-010119-t1x9gknd 4944 3 of of IN cord-010119-t1x9gknd 4944 4 appointment appointment NN cord-010119-t1x9gknd 4944 5 booking booking NN cord-010119-t1x9gknd 4944 6 at at IN cord-010119-t1x9gknd 4944 7 other other JJ cord-010119-t1x9gknd 4944 8 blood blood NN cord-010119-t1x9gknd 4944 9 bank bank NN cord-010119-t1x9gknd 4944 10 branches branch NNS cord-010119-t1x9gknd 4944 11 showed show VBD cord-010119-t1x9gknd 4944 12 that that IN cord-010119-t1x9gknd 4944 13 donors donor NNS cord-010119-t1x9gknd 4944 14 who who WP cord-010119-t1x9gknd 4944 15 booked book VBD cord-010119-t1x9gknd 4944 16 appointment appointment NN cord-010119-t1x9gknd 4944 17 through through IN cord-010119-t1x9gknd 4944 18 Donor Donor NNP cord-010119-t1x9gknd 4944 19 - - HYPH cord-010119-t1x9gknd 4944 20 Care Care NNP cord-010119-t1x9gknd 4944 21 was be VBD cord-010119-t1x9gknd 4944 22 19 19 CD cord-010119-t1x9gknd 4944 23 % % NN cord-010119-t1x9gknd 4944 24 . . . cord-010119-t1x9gknd 4945 1 A a DT cord-010119-t1x9gknd 4945 2 comparison comparison NN cord-010119-t1x9gknd 4945 3 was be VBD cord-010119-t1x9gknd 4945 4 made make VBN cord-010119-t1x9gknd 4945 5 and and CC cord-010119-t1x9gknd 4945 6 found find VBN cord-010119-t1x9gknd 4945 7 that that IN cord-010119-t1x9gknd 4945 8 this this DT cord-010119-t1x9gknd 4945 9 study study NN cord-010119-t1x9gknd 4945 10 shown show VBD cord-010119-t1x9gknd 4945 11 a a DT cord-010119-t1x9gknd 4945 12 significant significant JJ cord-010119-t1x9gknd 4945 13 increase increase NN cord-010119-t1x9gknd 4945 14 of of IN cord-010119-t1x9gknd 4945 15 acceptance acceptance NN cord-010119-t1x9gknd 4945 16 rate rate NN cord-010119-t1x9gknd 4945 17 by by IN cord-010119-t1x9gknd 4945 18 66 66 CD cord-010119-t1x9gknd 4945 19 % % NN cord-010119-t1x9gknd 4945 20 . . . cord-010119-t1x9gknd 4946 1 Conclusion conclusion NN cord-010119-t1x9gknd 4946 2 : : : cord-010119-t1x9gknd 4946 3 Generally generally RB cord-010119-t1x9gknd 4946 4 , , , cord-010119-t1x9gknd 4946 5 the the DT cord-010119-t1x9gknd 4946 6 results result NNS cord-010119-t1x9gknd 4946 7 were be VBD cord-010119-t1x9gknd 4946 8 positive positive JJ cord-010119-t1x9gknd 4946 9 and and CC cord-010119-t1x9gknd 4946 10 the the DT cord-010119-t1x9gknd 4946 11 automatic automatic JJ cord-010119-t1x9gknd 4946 12 appointment appointment NN cord-010119-t1x9gknd 4946 13 booking booking NN cord-010119-t1x9gknd 4946 14 system system NN cord-010119-t1x9gknd 4946 15 enabled enable VBD cord-010119-t1x9gknd 4946 16 BSG BSG NNP cord-010119-t1x9gknd 4946 17 to to TO cord-010119-t1x9gknd 4946 18 predict predict VB cord-010119-t1x9gknd 4946 19 donor donor NN cord-010119-t1x9gknd 4946 20 attendance attendance NN cord-010119-t1x9gknd 4946 21 , , , cord-010119-t1x9gknd 4946 22 ensure ensure VB cord-010119-t1x9gknd 4946 23 better well JJR cord-010119-t1x9gknd 4946 24 manpower manpower NN cord-010119-t1x9gknd 4946 25 management management NN cord-010119-t1x9gknd 4946 26 to to TO cord-010119-t1x9gknd 4946 27 reduce reduce VB cord-010119-t1x9gknd 4946 28 donor donor NN cord-010119-t1x9gknd 4946 29 turnaround turnaround NN cord-010119-t1x9gknd 4946 30 time time NN cord-010119-t1x9gknd 4946 31 and and CC cord-010119-t1x9gknd 4946 32 thus thus RB cord-010119-t1x9gknd 4946 33 hopefully hopefully RB cord-010119-t1x9gknd 4946 34 improve improve VB cord-010119-t1x9gknd 4946 35 donor donor NN cord-010119-t1x9gknd 4946 36 retention retention NN cord-010119-t1x9gknd 4946 37 . . . cord-010119-t1x9gknd 4947 1 BSG BSG NNP cord-010119-t1x9gknd 4947 2 is be VBZ cord-010119-t1x9gknd 4947 3 still still RB cord-010119-t1x9gknd 4947 4 monitoring monitor VBG cord-010119-t1x9gknd 4947 5 this this DT cord-010119-t1x9gknd 4947 6 automatic automatic JJ cord-010119-t1x9gknd 4947 7 appointment appointment NN cord-010119-t1x9gknd 4947 8 system system NN cord-010119-t1x9gknd 4947 9 and and CC cord-010119-t1x9gknd 4947 10 future future JJ cord-010119-t1x9gknd 4947 11 study study NN cord-010119-t1x9gknd 4947 12 are be VBP cord-010119-t1x9gknd 4947 13 still still RB cord-010119-t1x9gknd 4947 14 required require VBN cord-010119-t1x9gknd 4947 15 to to TO cord-010119-t1x9gknd 4947 16 determine determine VB cord-010119-t1x9gknd 4947 17 the the DT cord-010119-t1x9gknd 4947 18 effectiveness effectiveness NN cord-010119-t1x9gknd 4947 19 of of IN cord-010119-t1x9gknd 4947 20 automatic automatic JJ cord-010119-t1x9gknd 4947 21 appointment appointment NN cord-010119-t1x9gknd 4947 22 booking booking NN cord-010119-t1x9gknd 4947 23 , , , cord-010119-t1x9gknd 4947 24 donor donor NN cord-010119-t1x9gknd 4947 25 return return NN cord-010119-t1x9gknd 4947 26 and and CC cord-010119-t1x9gknd 4947 27 retention retention NN cord-010119-t1x9gknd 4947 28 rate rate NN cord-010119-t1x9gknd 4947 29 . . . cord-010119-t1x9gknd 4948 1 Currently currently RB cord-010119-t1x9gknd 4948 2 BSG BSG NNP cord-010119-t1x9gknd 4948 3 has have VBZ cord-010119-t1x9gknd 4948 4 4 4 CD cord-010119-t1x9gknd 4948 5 collection collection NN cord-010119-t1x9gknd 4948 6 centers center NNS cord-010119-t1x9gknd 4948 7 , , , cord-010119-t1x9gknd 4948 8 each each DT cord-010119-t1x9gknd 4948 9 managing manage VBG cord-010119-t1x9gknd 4948 10 its -PRON- PRP$ cord-010119-t1x9gknd 4948 11 own own JJ cord-010119-t1x9gknd 4948 12 appointment appointment NN cord-010119-t1x9gknd 4948 13 system system NN cord-010119-t1x9gknd 4948 14 . . . cord-010119-t1x9gknd 4949 1 The the DT cord-010119-t1x9gknd 4949 2 eventual eventual JJ cord-010119-t1x9gknd 4949 3 aim aim NN cord-010119-t1x9gknd 4949 4 is be VBZ cord-010119-t1x9gknd 4949 5 to to TO cord-010119-t1x9gknd 4949 6 be be VB cord-010119-t1x9gknd 4949 7 able able JJ cord-010119-t1x9gknd 4949 8 to to TO cord-010119-t1x9gknd 4949 9 have have VB cord-010119-t1x9gknd 4949 10 a a DT cord-010119-t1x9gknd 4949 11 centralized centralized JJ cord-010119-t1x9gknd 4949 12 appointment appointment NN cord-010119-t1x9gknd 4949 13 booking booking NN cord-010119-t1x9gknd 4949 14 system system NN cord-010119-t1x9gknd 4949 15 whereby whereby WRB cord-010119-t1x9gknd 4949 16 donors donor NNS cord-010119-t1x9gknd 4949 17 can can MD cord-010119-t1x9gknd 4949 18 book book VB cord-010119-t1x9gknd 4949 19 appointments appointment NNS cord-010119-t1x9gknd 4949 20 and and CC cord-010119-t1x9gknd 4949 21 still still RB cord-010119-t1x9gknd 4949 22 be be VB cord-010119-t1x9gknd 4949 23 able able JJ cord-010119-t1x9gknd 4949 24 to to TO cord-010119-t1x9gknd 4949 25 donate donate VB cord-010119-t1x9gknd 4949 26 at at IN cord-010119-t1x9gknd 4949 27 any any DT cord-010119-t1x9gknd 4949 28 collection collection NN cord-010119-t1x9gknd 4949 29 site site NN cord-010119-t1x9gknd 4949 30 . . . cord-010119-t1x9gknd 4950 1 4 4 LS cord-010119-t1x9gknd 4950 2 ) ) -RRB- cord-010119-t1x9gknd 4950 3 , , , cord-010119-t1x9gknd 4950 4 3.28 3.28 CD cord-010119-t1x9gknd 4950 5 0.4940 0.4940 CD cord-010119-t1x9gknd 4950 6 4 4 CD cord-010119-t1x9gknd 4950 7 1 1 CD cord-010119-t1x9gknd 4950 8 poisson poisson NN cord-010119-t1x9gknd 4950 9 distribution distribution NN cord-010119-t1x9gknd 4950 10 , , , cord-010119-t1x9gknd 4950 11 2 2 CD cord-010119-t1x9gknd 4950 12 normal normal JJ cord-010119-t1x9gknd 4950 13 distribution distribution NN cord-010119-t1x9gknd 4950 14 , , , cord-010119-t1x9gknd 4950 15 3 3 CD cord-010119-t1x9gknd 4950 16 logistic logistic JJ cord-010119-t1x9gknd 4950 17 distribution distribution NN cord-010119-t1x9gknd 4950 18 , , , cord-010119-t1x9gknd 4950 19 4 4 CD cord-010119-t1x9gknd 4950 20 lognormal lognormal JJ cord-010119-t1x9gknd 4950 21 distribution distribution NN cord-010119-t1x9gknd 4950 22 105A 105a CD cord-010119-t1x9gknd 4950 23 TRANSFUSION transfusion NN cord-010119-t1x9gknd 4950 24 ( ( -LRB- cord-010119-t1x9gknd 4950 25 p>0.05 p>0.05 NNP cord-010119-t1x9gknd 4950 26 ) ) -RRB- cord-010119-t1x9gknd 4950 27 in in IN cord-010119-t1x9gknd 4950 28 donor donor NN cord-010119-t1x9gknd 4950 29 and and CC cord-010119-t1x9gknd 4950 30 reference reference NN cord-010119-t1x9gknd 4950 31 populations population NNS cord-010119-t1x9gknd 4950 32 except except IN cord-010119-t1x9gknd 4950 33 in in IN cord-010119-t1x9gknd 4950 34 younger young JJR cord-010119-t1x9gknd 4950 35 ( ( -LRB- cord-010119-t1x9gknd 4950 36 20 20 CD cord-010119-t1x9gknd 4950 37 - - SYM cord-010119-t1x9gknd 4950 38 44 44 CD cord-010119-t1x9gknd 4950 39 yrs yr NNS cord-010119-t1x9gknd 4950 40 ) ) -RRB- cord-010119-t1x9gknd 4950 41 male male JJ cord-010119-t1x9gknd 4950 42 donors donor NNS cord-010119-t1x9gknd 4950 43 ( ( -LRB- cord-010119-t1x9gknd 4950 44 p<0.0021 p<0.0021 VB cord-010119-t1x9gknd 4950 45 ; ; : cord-010119-t1x9gknd 4950 46 donor donor NN cord-010119-t1x9gknd 4950 47 4.9 4.9 CD cord-010119-t1x9gknd 4950 48 % % NN cord-010119-t1x9gknd 4950 49 , , , cord-010119-t1x9gknd 4950 50 reference reference NN cord-010119-t1x9gknd 4950 51 10.0 10.0 CD cord-010119-t1x9gknd 4950 52 % % NN cord-010119-t1x9gknd 4950 53 ) ) -RRB- cord-010119-t1x9gknd 4950 54 . . . cord-010119-t1x9gknd 4951 1 Mean mean JJ cord-010119-t1x9gknd 4951 2 donor donor NN cord-010119-t1x9gknd 4951 3 SBP SBP NNP cord-010119-t1x9gknd 4951 4 , , , cord-010119-t1x9gknd 4951 5 DBP DBP NNP cord-010119-t1x9gknd 4951 6 , , , cord-010119-t1x9gknd 4951 7 and and CC cord-010119-t1x9gknd 4951 8 pulse pulse NN cord-010119-t1x9gknd 4951 9 were be VBD cord-010119-t1x9gknd 4951 10 125 125 CD cord-010119-t1x9gknd 4951 11 6 6 CD cord-010119-t1x9gknd 4951 12 14.7 14.7 CD cord-010119-t1x9gknd 4951 13 mmHg mmHg NNS cord-010119-t1x9gknd 4951 14 , , , cord-010119-t1x9gknd 4951 15 75.1 75.1 CD cord-010119-t1x9gknd 4951 16 6 6 CD cord-010119-t1x9gknd 4951 17 9.6 9.6 CD cord-010119-t1x9gknd 4951 18 mmHg mmHg NNS cord-010119-t1x9gknd 4951 19 , , , cord-010119-t1x9gknd 4951 20 and and CC cord-010119-t1x9gknd 4951 21 75.9 75.9 CD cord-010119-t1x9gknd 4951 22 6 6 CD cord-010119-t1x9gknd 4951 23 11.2 11.2 CD cord-010119-t1x9gknd 4951 24 bpm bpm NN cord-010119-t1x9gknd 4951 25 , , , cord-010119-t1x9gknd 4951 26 respectively respectively RB cord-010119-t1x9gknd 4951 27 . . . cord-010119-t1x9gknd 4952 1 Screening screen VBG cord-010119-t1x9gknd 4952 2 blood blood NN cord-010119-t1x9gknd 4952 3 pressure pressure NN cord-010119-t1x9gknd 4952 4 levels level NNS cord-010119-t1x9gknd 4952 5 consistent consistent JJ cord-010119-t1x9gknd 4952 6 with with IN cord-010119-t1x9gknd 4952 7 hypertension hypertension NN cord-010119-t1x9gknd 4952 8 ( ( -LRB- cord-010119-t1x9gknd 4952 9 29.4 29.4 CD cord-010119-t1x9gknd 4952 10 % % NN cord-010119-t1x9gknd 4952 11 male male NN cord-010119-t1x9gknd 4952 12 ; ; : cord-010119-t1x9gknd 4952 13 16.6 16.6 CD cord-010119-t1x9gknd 4952 14 % % NN cord-010119-t1x9gknd 4952 15 female female NN cord-010119-t1x9gknd 4952 16 ) ) -RRB- cord-010119-t1x9gknd 4952 17 in in IN cord-010119-t1x9gknd 4952 18 the the DT cord-010119-t1x9gknd 4952 19 20 20 CD cord-010119-t1x9gknd 4952 20 - - SYM cord-010119-t1x9gknd 4952 21 44 44 CD cord-010119-t1x9gknd 4952 22 year year NN cord-010119-t1x9gknd 4952 23 donor donor NN cord-010119-t1x9gknd 4952 24 group group NN cord-010119-t1x9gknd 4952 25 , , , cord-010119-t1x9gknd 4952 26 significantly significantly RB cord-010119-t1x9gknd 4952 27 ( ( -LRB- cord-010119-t1x9gknd 4952 28 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 4952 29 ) ) -RRB- cord-010119-t1x9gknd 4952 30 higher high JJR cord-010119-t1x9gknd 4952 31 than than IN cord-010119-t1x9gknd 4952 32 the the DT cord-010119-t1x9gknd 4952 33 reference reference NN cord-010119-t1x9gknd 4952 34 population population NN cord-010119-t1x9gknd 4952 35 ( ( -LRB- cord-010119-t1x9gknd 4952 36 11.2 11.2 CD cord-010119-t1x9gknd 4952 37 % % NN cord-010119-t1x9gknd 4952 38 male male NN cord-010119-t1x9gknd 4952 39 ; ; : cord-010119-t1x9gknd 4952 40 8.7 8.7 CD cord-010119-t1x9gknd 4952 41 % % NN cord-010119-t1x9gknd 4952 42 female female NN cord-010119-t1x9gknd 4952 43 ) ) -RRB- cord-010119-t1x9gknd 4952 44 . . . cord-010119-t1x9gknd 4953 1 No no DT cord-010119-t1x9gknd 4953 2 differences difference NNS cord-010119-t1x9gknd 4953 3 were be VBD cord-010119-t1x9gknd 4953 4 observed observe VBN cord-010119-t1x9gknd 4953 5 in in IN cord-010119-t1x9gknd 4953 6 the the DT cord-010119-t1x9gknd 4953 7 45 45 CD cord-010119-t1x9gknd 4953 8 - - SYM cord-010119-t1x9gknd 4953 9 64 64 CD cord-010119-t1x9gknd 4953 10 year year NN cord-010119-t1x9gknd 4953 11 groups group NNS cord-010119-t1x9gknd 4953 12 . . . cord-010119-t1x9gknd 4954 1 Conclusion conclusion NN cord-010119-t1x9gknd 4954 2 : : : cord-010119-t1x9gknd 4954 3 Normal normal JJ cord-010119-t1x9gknd 4954 4 Source source NN cord-010119-t1x9gknd 4954 5 donor donor NN cord-010119-t1x9gknd 4954 6 demographic demographic JJ cord-010119-t1x9gknd 4954 7 and and CC cord-010119-t1x9gknd 4954 8 physiologic physiologic JJ cord-010119-t1x9gknd 4954 9 characteristics characteristic NNS cord-010119-t1x9gknd 4954 10 often often RB cord-010119-t1x9gknd 4954 11 paralleled parallel VBD cord-010119-t1x9gknd 4954 12 those those DT cord-010119-t1x9gknd 4954 13 of of IN cord-010119-t1x9gknd 4954 14 the the DT cord-010119-t1x9gknd 4954 15 reference reference NN cord-010119-t1x9gknd 4954 16 USA USA NNP cord-010119-t1x9gknd 4954 17 populations population NNS cord-010119-t1x9gknd 4954 18 . . . cord-010119-t1x9gknd 4955 1 However however RB cord-010119-t1x9gknd 4955 2 there there EX cord-010119-t1x9gknd 4955 3 were be VBD cord-010119-t1x9gknd 4955 4 differences difference NNS cord-010119-t1x9gknd 4955 5 including include VBG cord-010119-t1x9gknd 4955 6 lower low JJR cord-010119-t1x9gknd 4955 7 cholesterol cholesterol NN cord-010119-t1x9gknd 4955 8 levels level NNS cord-010119-t1x9gknd 4955 9 and and CC cord-010119-t1x9gknd 4955 10 a a DT cord-010119-t1x9gknd 4955 11 higher high JJR cord-010119-t1x9gknd 4955 12 rate rate NN cord-010119-t1x9gknd 4955 13 of of IN cord-010119-t1x9gknd 4955 14 high high JJ cord-010119-t1x9gknd 4955 15 blood blood NN cord-010119-t1x9gknd 4955 16 pressure pressure NN cord-010119-t1x9gknd 4955 17 in in IN cord-010119-t1x9gknd 4955 18 younger young JJR cord-010119-t1x9gknd 4955 19 donors donor NNS cord-010119-t1x9gknd 4955 20 and and CC cord-010119-t1x9gknd 4955 21 higher high JJR cord-010119-t1x9gknd 4955 22 weights weight NNS cord-010119-t1x9gknd 4955 23 in in IN cord-010119-t1x9gknd 4955 24 20 20 CD cord-010119-t1x9gknd 4955 25 - - SYM cord-010119-t1x9gknd 4955 26 49 49 CD cord-010119-t1x9gknd 4955 27 year year NN cord-010119-t1x9gknd 4955 28 old old JJ cord-010119-t1x9gknd 4955 29 females female NNS cord-010119-t1x9gknd 4955 30 . . . cord-010119-t1x9gknd 4956 1 Developing develop VBG cord-010119-t1x9gknd 4956 2 Blood Blood NNP cord-010119-t1x9gknd 4956 3 Donor Donor NNP cord-010119-t1x9gknd 4956 4 Educational Educational NNP cord-010119-t1x9gknd 4956 5 Materials material NNS cord-010119-t1x9gknd 4956 6 Gay Gay NNP cord-010119-t1x9gknd 4956 7 Wehrli Wehrli NNP cord-010119-t1x9gknd 4956 8 * * NFP cord-010119-t1x9gknd 4956 9 1 1 CD cord-010119-t1x9gknd 4956 10 , , , cord-010119-t1x9gknd 4956 11 Susan Susan NNP cord-010119-t1x9gknd 4956 12 Rossmann Rossmann NNP cord-010119-t1x9gknd 4956 13 2 2 CD cord-010119-t1x9gknd 4956 14 , , , cord-010119-t1x9gknd 4956 15 Louis Louis NNP cord-010119-t1x9gknd 4956 16 M. M. NNP cord-010119-t1x9gknd 4956 17 Katz Katz NNP cord-010119-t1x9gknd 4956 18 3 3 CD cord-010119-t1x9gknd 4956 19 and and CC cord-010119-t1x9gknd 4956 20 Dan Dan NNP cord-010119-t1x9gknd 4956 21 A A NNP cord-010119-t1x9gknd 4956 22 Waxman Waxman NNP cord-010119-t1x9gknd 4956 23 4 4 CD cord-010119-t1x9gknd 4956 24 . . . cord-010119-t1x9gknd 4957 1 1 1 CD cord-010119-t1x9gknd 4957 2 University University NNP cord-010119-t1x9gknd 4957 3 of of IN cord-010119-t1x9gknd 4957 4 Virginia Virginia NNP cord-010119-t1x9gknd 4957 5 Health Health NNP cord-010119-t1x9gknd 4957 6 System System NNP cord-010119-t1x9gknd 4957 7 , , , cord-010119-t1x9gknd 4957 8 2 2 CD cord-010119-t1x9gknd 4957 9 Gulf Gulf NNP cord-010119-t1x9gknd 4957 10 Coast Coast NNP cord-010119-t1x9gknd 4957 11 Regional Regional NNP cord-010119-t1x9gknd 4957 12 Blood Blood NNP cord-010119-t1x9gknd 4957 13 Center Center NNP cord-010119-t1x9gknd 4957 14 -Sugar -Sugar NNP cord-010119-t1x9gknd 4957 15 Land Land NNP cord-010119-t1x9gknd 4957 16 , , , cord-010119-t1x9gknd 4957 17 3 3 CD cord-010119-t1x9gknd 4957 18 Americas Americas NNPS cord-010119-t1x9gknd 4957 19 Blood Blood NNP cord-010119-t1x9gknd 4957 20 Centers Centers NNPS cord-010119-t1x9gknd 4957 21 , , , cord-010119-t1x9gknd 4957 22 4 4 CD cord-010119-t1x9gknd 4957 23 Indiana Indiana NNP cord-010119-t1x9gknd 4957 24 Blood Blood NNP cord-010119-t1x9gknd 4957 25 Center Center NNP cord-010119-t1x9gknd 4957 26 Background Background NNP cord-010119-t1x9gknd 4957 27 / / SYM cord-010119-t1x9gknd 4957 28 Case Case NNP cord-010119-t1x9gknd 4957 29 Studies Studies NNPS cord-010119-t1x9gknd 4957 30 : : : cord-010119-t1x9gknd 4957 31 Donors donor NNS cord-010119-t1x9gknd 4957 32 must must MD cord-010119-t1x9gknd 4957 33 have have VB cord-010119-t1x9gknd 4957 34 sufficient sufficient JJ cord-010119-t1x9gknd 4957 35 information information NN cord-010119-t1x9gknd 4957 36 to to TO cord-010119-t1x9gknd 4957 37 make make VB cord-010119-t1x9gknd 4957 38 a a DT cord-010119-t1x9gknd 4957 39 decision decision NN cord-010119-t1x9gknd 4957 40 , , , cord-010119-t1x9gknd 4957 41 time time NN cord-010119-t1x9gknd 4957 42 to to TO cord-010119-t1x9gknd 4957 43 consider consider VB cord-010119-t1x9gknd 4957 44 options option NNS cord-010119-t1x9gknd 4957 45 before before IN cord-010119-t1x9gknd 4957 46 making make VBG cord-010119-t1x9gknd 4957 47 a a DT cord-010119-t1x9gknd 4957 48 decision decision NN cord-010119-t1x9gknd 4957 49 and and CC cord-010119-t1x9gknd 4957 50 an an DT cord-010119-t1x9gknd 4957 51 opportunity opportunity NN cord-010119-t1x9gknd 4957 52 to to TO cord-010119-t1x9gknd 4957 53 make make VB cord-010119-t1x9gknd 4957 54 a a DT cord-010119-t1x9gknd 4957 55 choice choice NN cord-010119-t1x9gknd 4957 56 of of IN cord-010119-t1x9gknd 4957 57 whether whether IN cord-010119-t1x9gknd 4957 58 to to TO cord-010119-t1x9gknd 4957 59 proceed proceed VB cord-010119-t1x9gknd 4957 60 with with IN cord-010119-t1x9gknd 4957 61 or or CC cord-010119-t1x9gknd 4957 62 decline decline VB cord-010119-t1x9gknd 4957 63 donating donating NN cord-010119-t1x9gknd 4957 64 . . . cord-010119-t1x9gknd 4958 1 Donor donor NN cord-010119-t1x9gknd 4958 2 education education NN cord-010119-t1x9gknd 4958 3 ( ( -LRB- cord-010119-t1x9gknd 4958 4 DE DE NNP cord-010119-t1x9gknd 4958 5 ) ) -RRB- cord-010119-t1x9gknd 4958 6 materials material NNS cord-010119-t1x9gknd 4958 7 must must MD cord-010119-t1x9gknd 4958 8 address address VB cord-010119-t1x9gknd 4958 9 mandates mandate NNS cord-010119-t1x9gknd 4958 10 set set VBN cord-010119-t1x9gknd 4958 11 forth forth RP cord-010119-t1x9gknd 4958 12 by by IN cord-010119-t1x9gknd 4958 13 regulatory regulatory JJ cord-010119-t1x9gknd 4958 14 agencies agency NNS cord-010119-t1x9gknd 4958 15 . . . cord-010119-t1x9gknd 4959 1 These these DT cord-010119-t1x9gknd 4959 2 materials material NNS cord-010119-t1x9gknd 4959 3 must must MD cord-010119-t1x9gknd 4959 4 be be VB cord-010119-t1x9gknd 4959 5 accessible accessible JJ cord-010119-t1x9gknd 4959 6 and and CC cord-010119-t1x9gknd 4959 7 understandable understandable JJ cord-010119-t1x9gknd 4959 8 by by IN cord-010119-t1x9gknd 4959 9 the the DT cord-010119-t1x9gknd 4959 10 general general JJ cord-010119-t1x9gknd 4959 11 population population NN cord-010119-t1x9gknd 4959 12 . . . cord-010119-t1x9gknd 4960 1 The the DT cord-010119-t1x9gknd 4960 2 goal goal NN cord-010119-t1x9gknd 4960 3 of of IN cord-010119-t1x9gknd 4960 4 this this DT cord-010119-t1x9gknd 4960 5 non non JJ cord-010119-t1x9gknd 4960 6 - - JJ cord-010119-t1x9gknd 4960 7 experimental experimental JJ cord-010119-t1x9gknd 4960 8 , , , cord-010119-t1x9gknd 4960 9 qualitative qualitative JJ cord-010119-t1x9gknd 4960 10 design design NN cord-010119-t1x9gknd 4960 11 study study NN cord-010119-t1x9gknd 4960 12 was be VBD cord-010119-t1x9gknd 4960 13 to to TO cord-010119-t1x9gknd 4960 14 evaluate evaluate VB cord-010119-t1x9gknd 4960 15 knowledge knowledge NN cord-010119-t1x9gknd 4960 16 acquired acquire VBN cord-010119-t1x9gknd 4960 17 through through IN cord-010119-t1x9gknd 4960 18 standardized standardize VBN cord-010119-t1x9gknd 4960 19 DE DE NNP cord-010119-t1x9gknd 4960 20 materials material NNS cord-010119-t1x9gknd 4960 21 . . . cord-010119-t1x9gknd 4961 1 This this DT cord-010119-t1x9gknd 4961 2 study study NN cord-010119-t1x9gknd 4961 3 was be VBD cord-010119-t1x9gknd 4961 4 IRB IRB NNP cord-010119-t1x9gknd 4961 5 approved approve VBD cord-010119-t1x9gknd 4961 6 as as IN cord-010119-t1x9gknd 4961 7 an an DT cord-010119-t1x9gknd 4961 8 exempt exempt JJ cord-010119-t1x9gknd 4961 9 protocol protocol NN cord-010119-t1x9gknd 4961 10 . . . cord-010119-t1x9gknd 4962 1 Study Study NNP cord-010119-t1x9gknd 4962 2 Design Design NNP cord-010119-t1x9gknd 4962 3 / / SYM cord-010119-t1x9gknd 4962 4 Method method NN cord-010119-t1x9gknd 4962 5 : : : cord-010119-t1x9gknd 4962 6 We -PRON- PRP cord-010119-t1x9gknd 4962 7 developed develop VBD cord-010119-t1x9gknd 4962 8 a a DT cord-010119-t1x9gknd 4962 9 DE DE NNP cord-010119-t1x9gknd 4962 10 document document NN cord-010119-t1x9gknd 4962 11 written write VBN cord-010119-t1x9gknd 4962 12 at at IN cord-010119-t1x9gknd 4962 13 an an DT cord-010119-t1x9gknd 4962 14 8 8 CD cord-010119-t1x9gknd 4962 15 th th XX cord-010119-t1x9gknd 4962 16 grade grade NN cord-010119-t1x9gknd 4962 17 comprehension comprehension NN cord-010119-t1x9gknd 4962 18 level level NN cord-010119-t1x9gknd 4962 19 . . . cord-010119-t1x9gknd 4963 1 A a DT cord-010119-t1x9gknd 4963 2 convenience convenience NN cord-010119-t1x9gknd 4963 3 sample sample NN cord-010119-t1x9gknd 4963 4 of of IN cord-010119-t1x9gknd 4963 5 volunteers volunteer NNS cord-010119-t1x9gknd 4963 6 was be VBD cord-010119-t1x9gknd 4963 7 identified identify VBN cord-010119-t1x9gknd 4963 8 for for IN cord-010119-t1x9gknd 4963 9 this this DT cord-010119-t1x9gknd 4963 10 two two CD cord-010119-t1x9gknd 4963 11 - - HYPH cord-010119-t1x9gknd 4963 12 part part NN cord-010119-t1x9gknd 4963 13 study study NN cord-010119-t1x9gknd 4963 14 . . . cord-010119-t1x9gknd 4964 1 A a DT cord-010119-t1x9gknd 4964 2 focus focus NN cord-010119-t1x9gknd 4964 3 group group NN cord-010119-t1x9gknd 4964 4 ( ( -LRB- cord-010119-t1x9gknd 4964 5 FG FG NNP cord-010119-t1x9gknd 4964 6 ) ) -RRB- cord-010119-t1x9gknd 4964 7 incorporated incorporate VBD cord-010119-t1x9gknd 4964 8 a a DT cord-010119-t1x9gknd 4964 9 pre pre NN cord-010119-t1x9gknd 4964 10 - - JJ cord-010119-t1x9gknd 4964 11 and and CC cord-010119-t1x9gknd 4964 12 post post JJ cord-010119-t1x9gknd 4964 13 - - NN cord-010119-t1x9gknd 4964 14 quiz quiz NN cord-010119-t1x9gknd 4964 15 for for IN cord-010119-t1x9gknd 4964 16 knowledge knowledge NN cord-010119-t1x9gknd 4964 17 acquisition acquisition NN cord-010119-t1x9gknd 4964 18 from from IN cord-010119-t1x9gknd 4964 19 reading read VBG cord-010119-t1x9gknd 4964 20 the the DT cord-010119-t1x9gknd 4964 21 four four CD cord-010119-t1x9gknd 4964 22 - - HYPH cord-010119-t1x9gknd 4964 23 page page NN cord-010119-t1x9gknd 4964 24 DE DE NNP cord-010119-t1x9gknd 4964 25 document document NN cord-010119-t1x9gknd 4964 26 . . . cord-010119-t1x9gknd 4965 1 The the DT cord-010119-t1x9gknd 4965 2 quiz quiz NN cord-010119-t1x9gknd 4965 3 was be VBD cord-010119-t1x9gknd 4965 4 followed follow VBN cord-010119-t1x9gknd 4965 5 by by IN cord-010119-t1x9gknd 4965 6 a a DT cord-010119-t1x9gknd 4965 7 group group NN cord-010119-t1x9gknd 4965 8 discussion discussion NN cord-010119-t1x9gknd 4965 9 for for IN cord-010119-t1x9gknd 4965 10 feedback feedback NN cord-010119-t1x9gknd 4965 11 . . . cord-010119-t1x9gknd 4966 1 The the DT cord-010119-t1x9gknd 4966 2 preand preand JJ cord-010119-t1x9gknd 4966 3 post post JJ cord-010119-t1x9gknd 4966 4 - - NN cord-010119-t1x9gknd 4966 5 quiz quiz NN cord-010119-t1x9gknd 4966 6 contained contain VBD cord-010119-t1x9gknd 4966 7 the the DT cord-010119-t1x9gknd 4966 8 same same JJ cord-010119-t1x9gknd 4966 9 10 10 CD cord-010119-t1x9gknd 4966 10 multiple multiple JJ cord-010119-t1x9gknd 4966 11 choice choice NN cord-010119-t1x9gknd 4966 12 questions question NNS cord-010119-t1x9gknd 4966 13 with with IN cord-010119-t1x9gknd 4966 14 single single JJ cord-010119-t1x9gknd 4966 15 best good JJS cord-010119-t1x9gknd 4966 16 answers answer NNS cord-010119-t1x9gknd 4966 17 including include VBG cord-010119-t1x9gknd 4966 18 the the DT cord-010119-t1x9gknd 4966 19 option option NN cord-010119-t1x9gknd 4966 20 to to TO cord-010119-t1x9gknd 4966 21 answer answer VB cord-010119-t1x9gknd 4966 22 , , , cord-010119-t1x9gknd 4966 23 " " `` cord-010119-t1x9gknd 4966 24 I -PRON- PRP cord-010119-t1x9gknd 4966 25 do do VBP cord-010119-t1x9gknd 4966 26 n't not RB cord-010119-t1x9gknd 4966 27 know know VB cord-010119-t1x9gknd 4966 28 . . . cord-010119-t1x9gknd 4966 29 " " '' cord-010119-t1x9gknd 4967 1 The the DT cord-010119-t1x9gknd 4967 2 DE DE NNP cord-010119-t1x9gknd 4967 3 document document NN cord-010119-t1x9gknd 4967 4 was be VBD cord-010119-t1x9gknd 4967 5 revised revise VBN cord-010119-t1x9gknd 4967 6 based base VBN cord-010119-t1x9gknd 4967 7 upon upon IN cord-010119-t1x9gknd 4967 8 the the DT cord-010119-t1x9gknd 4967 9 FG FG NNP cord-010119-t1x9gknd 4967 10 feedback feedback NN cord-010119-t1x9gknd 4967 11 and and CC cord-010119-t1x9gknd 4967 12 quiz quiz NN cord-010119-t1x9gknd 4967 13 results result NNS cord-010119-t1x9gknd 4967 14 . . . cord-010119-t1x9gknd 4968 1 The the DT cord-010119-t1x9gknd 4968 2 revised revised JJ cord-010119-t1x9gknd 4968 3 , , , cord-010119-t1x9gknd 4968 4 3.5 3.5 CD cord-010119-t1x9gknd 4968 5 page page NN cord-010119-t1x9gknd 4968 6 , , , cord-010119-t1x9gknd 4968 7 DE DE NNP cord-010119-t1x9gknd 4968 8 document document NN cord-010119-t1x9gknd 4968 9 was be VBD cord-010119-t1x9gknd 4968 10 then then RB cord-010119-t1x9gknd 4968 11 tested test VBN cord-010119-t1x9gknd 4968 12 using use VBG cord-010119-t1x9gknd 4968 13 the the DT cord-010119-t1x9gknd 4968 14 same same JJ cord-010119-t1x9gknd 4968 15 pre pre JJ cord-010119-t1x9gknd 4968 16 - - JJ cord-010119-t1x9gknd 4968 17 and and CC cord-010119-t1x9gknd 4968 18 post post JJ cord-010119-t1x9gknd 4968 19 - - NN cord-010119-t1x9gknd 4968 20 quiz quiz NN cord-010119-t1x9gknd 4968 21 during during IN cord-010119-t1x9gknd 4968 22 individual individual JJ cord-010119-t1x9gknd 4968 23 interviews interview NNS cord-010119-t1x9gknd 4968 24 ( ( -LRB- cord-010119-t1x9gknd 4968 25 II II NNP cord-010119-t1x9gknd 4968 26 ) ) -RRB- cord-010119-t1x9gknd 4968 27 . . . cord-010119-t1x9gknd 4969 1 Results/ Results/ . cord-010119-t1x9gknd 4970 1 Finding finding NN cord-010119-t1x9gknd 4970 2 : : : cord-010119-t1x9gknd 4971 1 Demographics demographic NNS cord-010119-t1x9gknd 4971 2 and and CC cord-010119-t1x9gknd 4971 3 quiz quiz NN cord-010119-t1x9gknd 4971 4 results result NNS cord-010119-t1x9gknd 4971 5 are be VBP cord-010119-t1x9gknd 4971 6 summarized summarize VBN cord-010119-t1x9gknd 4971 7 in in IN cord-010119-t1x9gknd 4971 8 table table NN cord-010119-t1x9gknd 4971 9 1 1 CD cord-010119-t1x9gknd 4971 10 . . . cord-010119-t1x9gknd 4972 1 Results result NNS cord-010119-t1x9gknd 4972 2 from from IN cord-010119-t1x9gknd 4972 3 the the DT cord-010119-t1x9gknd 4972 4 FG FG NNP cord-010119-t1x9gknd 4972 5 and and CC cord-010119-t1x9gknd 4972 6 II II NNP cord-010119-t1x9gknd 4972 7 revealed reveal VBD cord-010119-t1x9gknd 4972 8 a a DT cord-010119-t1x9gknd 4972 9 lack lack NN cord-010119-t1x9gknd 4972 10 of of IN cord-010119-t1x9gknd 4972 11 knowledge knowledge NN cord-010119-t1x9gknd 4972 12 in in IN cord-010119-t1x9gknd 4972 13 four four CD cord-010119-t1x9gknd 4972 14 areas area NNS cord-010119-t1x9gknd 4972 15 : : : cord-010119-t1x9gknd 4972 16 a a DT cord-010119-t1x9gknd 4972 17 donor donor NN cord-010119-t1x9gknd 4972 18 might may MD cord-010119-t1x9gknd 4972 19 be be VB cord-010119-t1x9gknd 4972 20 asked ask VBN cord-010119-t1x9gknd 4972 21 not not RB cord-010119-t1x9gknd 4972 22 to to TO cord-010119-t1x9gknd 4972 23 donate donate VB cord-010119-t1x9gknd 4972 24 at at IN cord-010119-t1x9gknd 4972 25 any any DT cord-010119-t1x9gknd 4972 26 time time NN cord-010119-t1x9gknd 4972 27 during during IN cord-010119-t1x9gknd 4972 28 the the DT cord-010119-t1x9gknd 4972 29 donation donation NN cord-010119-t1x9gknd 4972 30 process process NN cord-010119-t1x9gknd 4972 31 , , , cord-010119-t1x9gknd 4972 32 the the DT cord-010119-t1x9gknd 4972 33 need need NN cord-010119-t1x9gknd 4972 34 for for IN cord-010119-t1x9gknd 4972 35 photo photo NN cord-010119-t1x9gknd 4972 36 identification identification NN cord-010119-t1x9gknd 4972 37 to to TO cord-010119-t1x9gknd 4972 38 donate donate VB cord-010119-t1x9gknd 4972 39 , , , cord-010119-t1x9gknd 4972 40 iron iron NN cord-010119-t1x9gknd 4972 41 helps help VBZ cord-010119-t1x9gknd 4972 42 increase increase VB cord-010119-t1x9gknd 4972 43 a a DT cord-010119-t1x9gknd 4972 44 low low JJ cord-010119-t1x9gknd 4972 45 red red JJ cord-010119-t1x9gknd 4972 46 blood blood NN cord-010119-t1x9gknd 4972 47 cell cell NN cord-010119-t1x9gknd 4972 48 level level NN cord-010119-t1x9gknd 4972 49 , , , cord-010119-t1x9gknd 4972 50 and and CC cord-010119-t1x9gknd 4972 51 not not RB cord-010119-t1x9gknd 4972 52 to to TO cord-010119-t1x9gknd 4972 53 donate donate VB cord-010119-t1x9gknd 4972 54 for for IN cord-010119-t1x9gknd 4972 55 the the DT cord-010119-t1x9gknd 4972 56 sole sole JJ cord-010119-t1x9gknd 4972 57 purpose purpose NN cord-010119-t1x9gknd 4972 58 to to TO cord-010119-t1x9gknd 4972 59 obtain obtain VB cord-010119-t1x9gknd 4972 60 HIV HIV NNP cord-010119-t1x9gknd 4972 61 testing testing NN cord-010119-t1x9gknd 4972 62 . . . cord-010119-t1x9gknd 4973 1 Post post NN cord-010119-t1x9gknd 4973 2 - - NNS cord-010119-t1x9gknd 4973 3 quizzes quiz NNS cord-010119-t1x9gknd 4973 4 from from IN cord-010119-t1x9gknd 4973 5 the the DT cord-010119-t1x9gknd 4973 6 II II NNP cord-010119-t1x9gknd 4973 7 group group NN cord-010119-t1x9gknd 4973 8 revealed reveal VBD cord-010119-t1x9gknd 4973 9 an an DT cord-010119-t1x9gknd 4973 10 improvement improvement NN cord-010119-t1x9gknd 4973 11 in in IN cord-010119-t1x9gknd 4973 12 knowledge knowledge NN cord-010119-t1x9gknd 4973 13 acquisition acquisition NN cord-010119-t1x9gknd 4973 14 for for IN cord-010119-t1x9gknd 4973 15 all all DT cord-010119-t1x9gknd 4973 16 four four CD cord-010119-t1x9gknd 4973 17 areas area NNS cord-010119-t1x9gknd 4973 18 . . . cord-010119-t1x9gknd 4974 1 Feedback Feedback NNS cord-010119-t1x9gknd 4974 2 from from IN cord-010119-t1x9gknd 4974 3 both both DT cord-010119-t1x9gknd 4974 4 groups group NNS cord-010119-t1x9gknd 4974 5 reiterated reiterate VBD cord-010119-t1x9gknd 4974 6 that that IN cord-010119-t1x9gknd 4974 7 the the DT cord-010119-t1x9gknd 4974 8 document document NN cord-010119-t1x9gknd 4974 9 was be VBD cord-010119-t1x9gknd 4974 10 too too RB cord-010119-t1x9gknd 4974 11 long long JJ cord-010119-t1x9gknd 4974 12 . . . cord-010119-t1x9gknd 4975 1 Conclusion conclusion NN cord-010119-t1x9gknd 4975 2 : : : cord-010119-t1x9gknd 4976 1 Developing develop VBG cord-010119-t1x9gknd 4976 2 DE DE NNP cord-010119-t1x9gknd 4976 3 materials material NNS cord-010119-t1x9gknd 4976 4 requires require VBZ cord-010119-t1x9gknd 4976 5 a a DT cord-010119-t1x9gknd 4976 6 complicated complicated JJ cord-010119-t1x9gknd 4976 7 balance balance NN cord-010119-t1x9gknd 4976 8 of of IN cord-010119-t1x9gknd 4976 9 providing provide VBG cord-010119-t1x9gknd 4976 10 critical critical JJ cord-010119-t1x9gknd 4976 11 information information NN cord-010119-t1x9gknd 4976 12 , , , cord-010119-t1x9gknd 4976 13 concisely concisely RB cord-010119-t1x9gknd 4976 14 and and CC cord-010119-t1x9gknd 4976 15 at at IN cord-010119-t1x9gknd 4976 16 an an DT cord-010119-t1x9gknd 4976 17 appropriate appropriate JJ cord-010119-t1x9gknd 4976 18 comprehension comprehension NN cord-010119-t1x9gknd 4976 19 level level NN cord-010119-t1x9gknd 4976 20 ( ( -LRB- cord-010119-t1x9gknd 4976 21 8 8 CD cord-010119-t1x9gknd 4976 22 th th XX cord-010119-t1x9gknd 4976 23 grade grade NN cord-010119-t1x9gknd 4976 24 ) ) -RRB- cord-010119-t1x9gknd 4976 25 . . . cord-010119-t1x9gknd 4977 1 Testing test VBG cord-010119-t1x9gknd 4977 2 DE DE NNP cord-010119-t1x9gknd 4977 3 materials material NNS cord-010119-t1x9gknd 4977 4 is be VBZ cord-010119-t1x9gknd 4977 5 an an DT cord-010119-t1x9gknd 4977 6 essential essential JJ cord-010119-t1x9gknd 4977 7 step step NN cord-010119-t1x9gknd 4977 8 in in IN cord-010119-t1x9gknd 4977 9 the the DT cord-010119-t1x9gknd 4977 10 development development NN cord-010119-t1x9gknd 4977 11 process process NN cord-010119-t1x9gknd 4977 12 to to TO cord-010119-t1x9gknd 4977 13 ensure ensure VB cord-010119-t1x9gknd 4977 14 the the DT cord-010119-t1x9gknd 4977 15 intended intend VBN cord-010119-t1x9gknd 4977 16 knowledge knowledge NN cord-010119-t1x9gknd 4977 17 is be VBZ cord-010119-t1x9gknd 4977 18 acquired acquire VBN cord-010119-t1x9gknd 4977 19 by by IN cord-010119-t1x9gknd 4977 20 the the DT cord-010119-t1x9gknd 4977 21 end end NN cord-010119-t1x9gknd 4977 22 user user NN cord-010119-t1x9gknd 4977 23 population population NN cord-010119-t1x9gknd 4977 24 . . . cord-010119-t1x9gknd 4978 1 The the DT cord-010119-t1x9gknd 4978 2 next next JJ cord-010119-t1x9gknd 4978 3 steps step NNS cord-010119-t1x9gknd 4978 4 for for IN cord-010119-t1x9gknd 4978 5 this this DT cord-010119-t1x9gknd 4978 6 group group NN cord-010119-t1x9gknd 4978 7 will will MD cord-010119-t1x9gknd 4978 8 be be VB cord-010119-t1x9gknd 4978 9 to to TO cord-010119-t1x9gknd 4978 10 pilot pilot VB cord-010119-t1x9gknd 4978 11 the the DT cord-010119-t1x9gknd 4978 12 further further RB cord-010119-t1x9gknd 4978 13 revised revise VBN cord-010119-t1x9gknd 4978 14 , , , cord-010119-t1x9gknd 4978 15 two two CD cord-010119-t1x9gknd 4978 16 - - HYPH cord-010119-t1x9gknd 4978 17 page page NN cord-010119-t1x9gknd 4978 18 DE DE NNP cord-010119-t1x9gknd 4978 19 document document NN cord-010119-t1x9gknd 4978 20 at at IN cord-010119-t1x9gknd 4978 21 donation donation NN cord-010119-t1x9gknd 4978 22 sites site NNS cord-010119-t1x9gknd 4978 23 . . . cord-010119-t1x9gknd 4979 1 Effect Effect NNP cord-010119-t1x9gknd 4979 2 Analysis Analysis NNP cord-010119-t1x9gknd 4979 3 of of IN cord-010119-t1x9gknd 4979 4 the the DT cord-010119-t1x9gknd 4979 5 ' ' `` cord-010119-t1x9gknd 4979 6 Rh(- Rh(- NNP cord-010119-t1x9gknd 4979 7 ) ) -RRB- cord-010119-t1x9gknd 4979 8 Blood Blood NNP cord-010119-t1x9gknd 4979 9 Supply Supply NNP cord-010119-t1x9gknd 4979 10 Program Program NNP cord-010119-t1x9gknd 4979 11 ' ' '' cord-010119-t1x9gknd 4979 12 Establishment Establishment NNP cord-010119-t1x9gknd 4979 13 HyeSung HyeSung NNP cord-010119-t1x9gknd 4979 14 Han Han NNP cord-010119-t1x9gknd 4979 15 * * NFP cord-010119-t1x9gknd 4979 16 , , , cord-010119-t1x9gknd 4979 17 DeokJa DeokJa NNP cord-010119-t1x9gknd 4979 18 Oh oh UH cord-010119-t1x9gknd 4979 19 , , , cord-010119-t1x9gknd 4980 1 BuJa BuJa NNP cord-010119-t1x9gknd 4980 2 Hur Hur NNP cord-010119-t1x9gknd 4980 3 and and CC cord-010119-t1x9gknd 4980 4 ChulYong ChulYong NNP cord-010119-t1x9gknd 4980 5 Kim Kim NNP cord-010119-t1x9gknd 4980 6 . . . cord-010119-t1x9gknd 4981 1 Korean Korean NNP cord-010119-t1x9gknd 4981 2 Red Red NNP cord-010119-t1x9gknd 4981 3 Cross Cross NNP cord-010119-t1x9gknd 4981 4 Blood Blood NNP cord-010119-t1x9gknd 4981 5 Services Services NNPS cord-010119-t1x9gknd 4981 6 Background Background NNP cord-010119-t1x9gknd 4981 7 / / SYM cord-010119-t1x9gknd 4981 8 Case Case NNP cord-010119-t1x9gknd 4981 9 Studies Studies NNPS cord-010119-t1x9gknd 4981 10 : : : cord-010119-t1x9gknd 4982 1 The the DT cord-010119-t1x9gknd 4982 2 Rh(- Rh(- NNP cord-010119-t1x9gknd 4982 3 ) ) -RRB- cord-010119-t1x9gknd 4982 4 blood blood NN cord-010119-t1x9gknd 4982 5 supply supply NN cord-010119-t1x9gknd 4982 6 program program NN cord-010119-t1x9gknd 4982 7 was be VBD cord-010119-t1x9gknd 4982 8 developed develop VBN cord-010119-t1x9gknd 4982 9 in in IN cord-010119-t1x9gknd 4982 10 2011 2011 CD cord-010119-t1x9gknd 4982 11 for for IN cord-010119-t1x9gknd 4982 12 the the DT cord-010119-t1x9gknd 4982 13 purpose purpose NN cord-010119-t1x9gknd 4982 14 of of IN cord-010119-t1x9gknd 4982 15 prompt prompt JJ cord-010119-t1x9gknd 4982 16 and and CC cord-010119-t1x9gknd 4982 17 stable stable JJ cord-010119-t1x9gknd 4982 18 blood blood NN cord-010119-t1x9gknd 4982 19 supply supply NN cord-010119-t1x9gknd 4982 20 . . . cord-010119-t1x9gknd 4983 1 Based base VBN cord-010119-t1x9gknd 4983 2 on on IN cord-010119-t1x9gknd 4983 3 the the DT cord-010119-t1x9gknd 4983 4 computerized computerized JJ cord-010119-t1x9gknd 4983 5 system system NN cord-010119-t1x9gknd 4983 6 , , , cord-010119-t1x9gknd 4983 7 the the DT cord-010119-t1x9gknd 4983 8 program program NN cord-010119-t1x9gknd 4983 9 operates operate VBZ cord-010119-t1x9gknd 4983 10 the the DT cord-010119-t1x9gknd 4983 11 emergency emergency NN cord-010119-t1x9gknd 4983 12 contact/ contact/ JJ cord-010119-t1x9gknd 4983 13 communication communication NN cord-010119-t1x9gknd 4983 14 . . . cord-010119-t1x9gknd 4984 1 This this DT cord-010119-t1x9gknd 4984 2 program program NN cord-010119-t1x9gknd 4984 3 has have VBZ cord-010119-t1x9gknd 4984 4 4 4 CD cord-010119-t1x9gknd 4984 5 major major JJ cord-010119-t1x9gknd 4984 6 functions function NNS cord-010119-t1x9gknd 4984 7 such such JJ cord-010119-t1x9gknd 4984 8 as as IN cord-010119-t1x9gknd 4984 9 the the DT cord-010119-t1x9gknd 4984 10 request request NN cord-010119-t1x9gknd 4984 11 of of IN cord-010119-t1x9gknd 4984 12 the the DT cord-010119-t1x9gknd 4984 13 emergency emergency NN cord-010119-t1x9gknd 4984 14 blood blood NN cord-010119-t1x9gknd 4984 15 , , , cord-010119-t1x9gknd 4984 16 the the DT cord-010119-t1x9gknd 4984 17 recruitment recruitment NN cord-010119-t1x9gknd 4984 18 and and CC cord-010119-t1x9gknd 4984 19 management management NN cord-010119-t1x9gknd 4984 20 of of IN cord-010119-t1x9gknd 4984 21 the the DT cord-010119-t1x9gknd 4984 22 Rh(- Rh(- NNP cord-010119-t1x9gknd 4984 23 ) ) -RRB- cord-010119-t1x9gknd 4984 24 blood blood NN cord-010119-t1x9gknd 4984 25 donors donor NNS cord-010119-t1x9gknd 4984 26 for for IN cord-010119-t1x9gknd 4984 27 the the DT cord-010119-t1x9gknd 4984 28 emergency emergency NN cord-010119-t1x9gknd 4984 29 blood blood NN cord-010119-t1x9gknd 4984 30 donation donation NN cord-010119-t1x9gknd 4984 31 , , , cord-010119-t1x9gknd 4984 32 real real JJ cord-010119-t1x9gknd 4984 33 - - HYPH cord-010119-t1x9gknd 4984 34 time time NN cord-010119-t1x9gknd 4984 35 blood blood NN cord-010119-t1x9gknd 4984 36 supply supply NN cord-010119-t1x9gknd 4984 37 status status NN cord-010119-t1x9gknd 4984 38 monitoring monitor VBG cord-010119-t1x9gknd 4984 39 program program NN cord-010119-t1x9gknd 4984 40 and and CC cord-010119-t1x9gknd 4984 41 statistics statistic NNS cord-010119-t1x9gknd 4984 42 program program NN cord-010119-t1x9gknd 4984 43 . . . cord-010119-t1x9gknd 4985 1 The the DT cord-010119-t1x9gknd 4985 2 aim aim NN cord-010119-t1x9gknd 4985 3 of of IN cord-010119-t1x9gknd 4985 4 the the DT cord-010119-t1x9gknd 4985 5 research research NN cord-010119-t1x9gknd 4985 6 is be VBZ cord-010119-t1x9gknd 4985 7 to to TO cord-010119-t1x9gknd 4985 8 validate validate VB cord-010119-t1x9gknd 4985 9 the the DT cord-010119-t1x9gknd 4985 10 effect effect NN cord-010119-t1x9gknd 4985 11 of of IN cord-010119-t1x9gknd 4985 12 Rh(- Rh(- NNP cord-010119-t1x9gknd 4985 13 ) ) -RRB- cord-010119-t1x9gknd 4985 14 blood blood NN cord-010119-t1x9gknd 4985 15 supply supply NN cord-010119-t1x9gknd 4985 16 program program NN cord-010119-t1x9gknd 4985 17 operations operation NNS cord-010119-t1x9gknd 4985 18 and and CC cord-010119-t1x9gknd 4985 19 the the DT cord-010119-t1x9gknd 4985 20 responsiveness responsiveness NN cord-010119-t1x9gknd 4985 21 of of IN cord-010119-t1x9gknd 4985 22 the the DT cord-010119-t1x9gknd 4985 23 emergency emergency NN cord-010119-t1x9gknd 4985 24 blood blood NN cord-010119-t1x9gknd 4985 25 supply supply NN cord-010119-t1x9gknd 4985 26 under under IN cord-010119-t1x9gknd 4985 27 the the DT cord-010119-t1x9gknd 4985 28 Rh(- Rh(- NNP cord-010119-t1x9gknd 4985 29 ) ) -RRB- cord-010119-t1x9gknd 4985 30 blood blood NN cord-010119-t1x9gknd 4985 31 supply supply NN cord-010119-t1x9gknd 4985 32 program program NN cord-010119-t1x9gknd 4985 33 . . . cord-010119-t1x9gknd 4986 1 Study Study NNP cord-010119-t1x9gknd 4986 2 Design Design NNP cord-010119-t1x9gknd 4986 3 / / SYM cord-010119-t1x9gknd 4986 4 Method method NN cord-010119-t1x9gknd 4986 5 : : : cord-010119-t1x9gknd 4986 6 Researchers researcher NNS cord-010119-t1x9gknd 4986 7 investigated investigate VBD cord-010119-t1x9gknd 4986 8 the the DT cord-010119-t1x9gknd 4986 9 database database NN cord-010119-t1x9gknd 4986 10 from from IN cord-010119-t1x9gknd 4986 11 2011 2011 CD cord-010119-t1x9gknd 4986 12 to to IN cord-010119-t1x9gknd 4986 13 2016 2016 CD cord-010119-t1x9gknd 4986 14 after after IN cord-010119-t1x9gknd 4986 15 the the DT cord-010119-t1x9gknd 4986 16 Rh(- Rh(- NNP cord-010119-t1x9gknd 4986 17 ) ) -RRB- cord-010119-t1x9gknd 4986 18 blood blood NN cord-010119-t1x9gknd 4986 19 supply supply NN cord-010119-t1x9gknd 4986 20 program program NN cord-010119-t1x9gknd 4986 21 was be VBD cord-010119-t1x9gknd 4986 22 developed develop VBN cord-010119-t1x9gknd 4986 23 . . . cord-010119-t1x9gknd 4987 1 Investigators investigator NNS cord-010119-t1x9gknd 4987 2 analyzed analyze VBD cord-010119-t1x9gknd 4987 3 and and CC cord-010119-t1x9gknd 4987 4 compared compare VBD cord-010119-t1x9gknd 4987 5 the the DT cord-010119-t1x9gknd 4987 6 recruitment recruitment NN cord-010119-t1x9gknd 4987 7 and and CC cord-010119-t1x9gknd 4987 8 blood blood NN cord-010119-t1x9gknd 4987 9 donation donation NN cord-010119-t1x9gknd 4987 10 of of IN cord-010119-t1x9gknd 4987 11 the the DT cord-010119-t1x9gknd 4987 12 Rh(- Rh(- NNP cord-010119-t1x9gknd 4987 13 ) ) -RRB- cord-010119-t1x9gknd 4987 14 blood blood NN cord-010119-t1x9gknd 4987 15 donors donor NNS cord-010119-t1x9gknd 4987 16 for for IN cord-010119-t1x9gknd 4987 17 the the DT cord-010119-t1x9gknd 4987 18 emergency emergency NN cord-010119-t1x9gknd 4987 19 blood blood NN cord-010119-t1x9gknd 4987 20 donation donation NN cord-010119-t1x9gknd 4987 21 and and CC cord-010119-t1x9gknd 4987 22 securing secure VBG cord-010119-t1x9gknd 4987 23 the the DT cord-010119-t1x9gknd 4987 24 blood blood NN cord-010119-t1x9gknd 4987 25 supply supply NN cord-010119-t1x9gknd 4987 26 upon upon IN cord-010119-t1x9gknd 4987 27 request request NN cord-010119-t1x9gknd 4987 28 . . . cord-010119-t1x9gknd 4988 1 Results/ Results/ . cord-010119-t1x9gknd 4989 1 Finding find VBG cord-010119-t1x9gknd 4989 2 : : : cord-010119-t1x9gknd 4989 3 The the DT cord-010119-t1x9gknd 4989 4 data data NN cord-010119-t1x9gknd 4989 5 shows show VBZ cord-010119-t1x9gknd 4989 6 that that IN cord-010119-t1x9gknd 4989 7 the the DT cord-010119-t1x9gknd 4989 8 number number NN cord-010119-t1x9gknd 4989 9 of of IN cord-010119-t1x9gknd 4989 10 voluntary voluntary JJ cord-010119-t1x9gknd 4989 11 blood blood NN cord-010119-t1x9gknd 4989 12 donors donor NNS cord-010119-t1x9gknd 4989 13 who who WP cord-010119-t1x9gknd 4989 14 pledge pledge VBP cord-010119-t1x9gknd 4989 15 to to TO cord-010119-t1x9gknd 4989 16 give give VB cord-010119-t1x9gknd 4989 17 blood blood NN cord-010119-t1x9gknd 4989 18 for for IN cord-010119-t1x9gknd 4989 19 the the DT cord-010119-t1x9gknd 4989 20 emergency emergency NN cord-010119-t1x9gknd 4989 21 blood blood NN cord-010119-t1x9gknd 4989 22 donation donation NN cord-010119-t1x9gknd 4989 23 has have VBZ cord-010119-t1x9gknd 4989 24 increased increase VBN cord-010119-t1x9gknd 4989 25 from from IN cord-010119-t1x9gknd 4989 26 5.6 5.6 CD cord-010119-t1x9gknd 4989 27 % % NN cord-010119-t1x9gknd 4989 28 to to IN cord-010119-t1x9gknd 4989 29 21.4 21.4 CD cord-010119-t1x9gknd 4989 30 % % NN cord-010119-t1x9gknd 4989 31 in in IN cord-010119-t1x9gknd 4989 32 2011 2011 CD cord-010119-t1x9gknd 4989 33 and and CC cord-010119-t1x9gknd 4989 34 2016 2016 CD cord-010119-t1x9gknd 4989 35 , , , cord-010119-t1x9gknd 4989 36 respectively respectively RB cord-010119-t1x9gknd 4989 37 . . . cord-010119-t1x9gknd 4990 1 Also also RB cord-010119-t1x9gknd 4990 2 , , , cord-010119-t1x9gknd 4990 3 the the DT cord-010119-t1x9gknd 4990 4 actual actual JJ cord-010119-t1x9gknd 4990 5 participation participation NN cord-010119-t1x9gknd 4990 6 rate rate NN cord-010119-t1x9gknd 4990 7 of of IN cord-010119-t1x9gknd 4990 8 Rh(- Rh(- NNP cord-010119-t1x9gknd 4990 9 ) ) -RRB- cord-010119-t1x9gknd 4990 10 blood blood NN cord-010119-t1x9gknd 4990 11 donations donation NNS cord-010119-t1x9gknd 4990 12 among among IN cord-010119-t1x9gknd 4990 13 the the DT cord-010119-t1x9gknd 4990 14 group group NN cord-010119-t1x9gknd 4990 15 who who WP cord-010119-t1x9gknd 4990 16 pledge pledge VBP cord-010119-t1x9gknd 4990 17 to to TO cord-010119-t1x9gknd 4990 18 give give VB cord-010119-t1x9gknd 4990 19 blood blood NN cord-010119-t1x9gknd 4990 20 for for IN cord-010119-t1x9gknd 4990 21 the the DT cord-010119-t1x9gknd 4990 22 emergency emergency NN cord-010119-t1x9gknd 4990 23 blood blood NN cord-010119-t1x9gknd 4990 24 donation donation NN cord-010119-t1x9gknd 4990 25 has have VBZ cord-010119-t1x9gknd 4990 26 increased increase VBN cord-010119-t1x9gknd 4990 27 from from IN cord-010119-t1x9gknd 4990 28 26.8 26.8 CD cord-010119-t1x9gknd 4990 29 % % NN cord-010119-t1x9gknd 4990 30 in in IN cord-010119-t1x9gknd 4990 31 2011 2011 CD cord-010119-t1x9gknd 4990 32 to to IN cord-010119-t1x9gknd 4990 33 57 57 CD cord-010119-t1x9gknd 4990 34 % % NN cord-010119-t1x9gknd 4990 35 in in IN cord-010119-t1x9gknd 4990 36 2016 2016 CD cord-010119-t1x9gknd 4990 37 . . . cord-010119-t1x9gknd 4991 1 Moreover moreover RB cord-010119-t1x9gknd 4991 2 , , , cord-010119-t1x9gknd 4991 3 the the DT cord-010119-t1x9gknd 4991 4 data data NN cord-010119-t1x9gknd 4991 5 has have VBZ cord-010119-t1x9gknd 4991 6 indicated indicate VBN cord-010119-t1x9gknd 4991 7 that that IN cord-010119-t1x9gknd 4991 8 the the DT cord-010119-t1x9gknd 4991 9 blood blood NN cord-010119-t1x9gknd 4991 10 supply supply NN cord-010119-t1x9gknd 4991 11 has have VBZ cord-010119-t1x9gknd 4991 12 fully fully RB cord-010119-t1x9gknd 4991 13 met meet VBN cord-010119-t1x9gknd 4991 14 the the DT cord-010119-t1x9gknd 4991 15 demand demand NN cord-010119-t1x9gknd 4991 16 for for IN cord-010119-t1x9gknd 4991 17 the the DT cord-010119-t1x9gknd 4991 18 emergency emergency NN cord-010119-t1x9gknd 4991 19 blood blood NN cord-010119-t1x9gknd 4991 20 request request NN cord-010119-t1x9gknd 4991 21 . . . cord-010119-t1x9gknd 4992 1 Conclusion conclusion NN cord-010119-t1x9gknd 4992 2 : : : cord-010119-t1x9gknd 4993 1 The the DT cord-010119-t1x9gknd 4993 2 result result NN cord-010119-t1x9gknd 4993 3 showed show VBD cord-010119-t1x9gknd 4993 4 that that IN cord-010119-t1x9gknd 4993 5 the the DT cord-010119-t1x9gknd 4993 6 Rh(- Rh(- NNP cord-010119-t1x9gknd 4993 7 ) ) -RRB- cord-010119-t1x9gknd 4993 8 blood blood NN cord-010119-t1x9gknd 4993 9 supply supply NN cord-010119-t1x9gknd 4993 10 program program NN cord-010119-t1x9gknd 4993 11 was be VBD cord-010119-t1x9gknd 4993 12 effective effective JJ cord-010119-t1x9gknd 4993 13 for for IN cord-010119-t1x9gknd 4993 14 the the DT cord-010119-t1x9gknd 4993 15 recruitment recruitment NN cord-010119-t1x9gknd 4993 16 / / SYM cord-010119-t1x9gknd 4993 17 management management NN cord-010119-t1x9gknd 4993 18 of of IN cord-010119-t1x9gknd 4993 19 the the DT cord-010119-t1x9gknd 4993 20 Rh(- Rh(- NNP cord-010119-t1x9gknd 4993 21 ) ) -RRB- cord-010119-t1x9gknd 4993 22 blood blood NN cord-010119-t1x9gknd 4993 23 donors donor NNS cord-010119-t1x9gknd 4993 24 for for IN cord-010119-t1x9gknd 4993 25 the the DT cord-010119-t1x9gknd 4993 26 emergency emergency NN cord-010119-t1x9gknd 4993 27 blood blood NN cord-010119-t1x9gknd 4993 28 donation donation NN cord-010119-t1x9gknd 4993 29 . . . cord-010119-t1x9gknd 4994 1 This this DT cord-010119-t1x9gknd 4994 2 system system NN cord-010119-t1x9gknd 4994 3 contributes contribute VBZ cord-010119-t1x9gknd 4994 4 to to IN cord-010119-t1x9gknd 4994 5 recruiting recruit VBG cord-010119-t1x9gknd 4994 6 and and CC cord-010119-t1x9gknd 4994 7 managing manage VBG cord-010119-t1x9gknd 4994 8 Rh(- Rh(- NNP cord-010119-t1x9gknd 4994 9 ) ) -RRB- cord-010119-t1x9gknd 4994 10 blood blood NN cord-010119-t1x9gknd 4994 11 donors donor NNS cord-010119-t1x9gknd 4994 12 who who WP cord-010119-t1x9gknd 4994 13 pledge pledge VBP cord-010119-t1x9gknd 4994 14 to to TO cord-010119-t1x9gknd 4994 15 donate donate VB cord-010119-t1x9gknd 4994 16 blood blood NN cord-010119-t1x9gknd 4994 17 and and CC cord-010119-t1x9gknd 4994 18 securing secure VBG cord-010119-t1x9gknd 4994 19 Rh(- rh(- NN cord-010119-t1x9gknd 4994 20 ) ) -RRB- cord-010119-t1x9gknd 4994 21 blood blood NN cord-010119-t1x9gknd 4994 22 in in IN cord-010119-t1x9gknd 4994 23 emergency emergency NN cord-010119-t1x9gknd 4994 24 situation situation NN cord-010119-t1x9gknd 4994 25 . . . cord-010119-t1x9gknd 4994 26 _SP cord-010119-t1x9gknd 4995 1 The the DT cord-010119-t1x9gknd 4995 2 institution institution NN cord-010119-t1x9gknd 4995 3 that that WDT cord-010119-t1x9gknd 4995 4 needs need VBZ cord-010119-t1x9gknd 4995 5 to to TO cord-010119-t1x9gknd 4995 6 meet meet VB cord-010119-t1x9gknd 4995 7 the the DT cord-010119-t1x9gknd 4995 8 demand demand NN cord-010119-t1x9gknd 4995 9 of of IN cord-010119-t1x9gknd 4995 10 rare rare JJ cord-010119-t1x9gknd 4995 11 blood blood NN cord-010119-t1x9gknd 4995 12 type type NN cord-010119-t1x9gknd 4995 13 could could MD cord-010119-t1x9gknd 4995 14 possibly possibly RB cord-010119-t1x9gknd 4995 15 use use VB cord-010119-t1x9gknd 4995 16 the the DT cord-010119-t1x9gknd 4995 17 Rh(- Rh(- NNP cord-010119-t1x9gknd 4995 18 ) ) -RRB- cord-010119-t1x9gknd 4995 19 blood blood NN cord-010119-t1x9gknd 4995 20 supply supply NN cord-010119-t1x9gknd 4995 21 program program NN cord-010119-t1x9gknd 4995 22 which which WDT cord-010119-t1x9gknd 4995 23 leads lead VBZ cord-010119-t1x9gknd 4995 24 to to IN cord-010119-t1x9gknd 4995 25 securing secure VBG cord-010119-t1x9gknd 4995 26 special special JJ cord-010119-t1x9gknd 4995 27 type type NN cord-010119-t1x9gknd 4995 28 blood blood NN cord-010119-t1x9gknd 4995 29 . . . cord-010119-t1x9gknd 4996 1 Hanwei Hanwei NNP cord-010119-t1x9gknd 4996 2 Chen Chen NNP cord-010119-t1x9gknd 4997 1 * * NFP cord-010119-t1x9gknd 4997 2 . . . cord-010119-t1x9gknd 4998 1 Wuhan Wuhan NNP cord-010119-t1x9gknd 4998 2 blood blood NN cord-010119-t1x9gknd 4998 3 center center NN cord-010119-t1x9gknd 4999 1 Background Background NNP cord-010119-t1x9gknd 4999 2 / / SYM cord-010119-t1x9gknd 4999 3 Case Case NNP cord-010119-t1x9gknd 4999 4 Studies Studies NNPS cord-010119-t1x9gknd 4999 5 : : : cord-010119-t1x9gknd 5000 1 In in IN cord-010119-t1x9gknd 5000 2 China China NNP cord-010119-t1x9gknd 5000 3 , , , cord-010119-t1x9gknd 5000 4 volunteer volunteer NN cord-010119-t1x9gknd 5000 5 blood blood NN cord-010119-t1x9gknd 5000 6 donors donor NNS cord-010119-t1x9gknd 5000 7 can can MD cord-010119-t1x9gknd 5000 8 donate donate VB cord-010119-t1x9gknd 5000 9 platelets platelet NNS cord-010119-t1x9gknd 5000 10 by by IN cord-010119-t1x9gknd 5000 11 apheresis apheresis NN cord-010119-t1x9gknd 5000 12 ( ( -LRB- cord-010119-t1x9gknd 5000 13 AP AP NNP cord-010119-t1x9gknd 5000 14 ) ) -RRB- cord-010119-t1x9gknd 5000 15 up up IN cord-010119-t1x9gknd 5000 16 to to TO cord-010119-t1x9gknd 5000 17 24 24 CD cord-010119-t1x9gknd 5000 18 times time NNS cord-010119-t1x9gknd 5000 19 per per IN cord-010119-t1x9gknd 5000 20 year year NN cord-010119-t1x9gknd 5000 21 . . . cord-010119-t1x9gknd 5001 1 However however RB cord-010119-t1x9gknd 5001 2 , , , cord-010119-t1x9gknd 5001 3 the the DT cord-010119-t1x9gknd 5001 4 awareness awareness NN cord-010119-t1x9gknd 5001 5 and and CC cord-010119-t1x9gknd 5001 6 knowledge knowledge NN cord-010119-t1x9gknd 5001 7 of of IN cord-010119-t1x9gknd 5001 8 AP AP NNP cord-010119-t1x9gknd 5001 9 donation donation NN cord-010119-t1x9gknd 5001 10 is be VBZ cord-010119-t1x9gknd 5001 11 much much RB cord-010119-t1x9gknd 5001 12 lower low JJR cord-010119-t1x9gknd 5001 13 than than IN cord-010119-t1x9gknd 5001 14 whole whole JJ cord-010119-t1x9gknd 5001 15 blood blood NN cord-010119-t1x9gknd 5001 16 donation donation NN cord-010119-t1x9gknd 5001 17 among among IN cord-010119-t1x9gknd 5001 18 the the DT cord-010119-t1x9gknd 5001 19 Chinese chinese JJ cord-010119-t1x9gknd 5001 20 population population NN cord-010119-t1x9gknd 5001 21 . . . cord-010119-t1x9gknd 5002 1 There there EX cord-010119-t1x9gknd 5002 2 are be VBP cord-010119-t1x9gknd 5002 3 approximately approximately RB cord-010119-t1x9gknd 5002 4 1.3 1.3 CD cord-010119-t1x9gknd 5002 5 million million CD cord-010119-t1x9gknd 5002 6 doses dose NNS cord-010119-t1x9gknd 5002 7 of of IN cord-010119-t1x9gknd 5002 8 AP AP NNP cord-010119-t1x9gknd 5002 9 transfused transfuse VBD cord-010119-t1x9gknd 5002 10 within within IN cord-010119-t1x9gknd 5002 11 1.375 1.375 CD cord-010119-t1x9gknd 5002 12 billion billion CD cord-010119-t1x9gknd 5002 13 people people NNS cord-010119-t1x9gknd 5002 14 each each DT cord-010119-t1x9gknd 5002 15 year year NN cord-010119-t1x9gknd 5002 16 In in IN cord-010119-t1x9gknd 5002 17 China China NNP cord-010119-t1x9gknd 5002 18 ; ; : cord-010119-t1x9gknd 5002 19 It -PRON- PRP cord-010119-t1x9gknd 5002 20 is be VBZ cord-010119-t1x9gknd 5002 21 one one CD cord-010119-t1x9gknd 5002 22 challenge challenge NN cord-010119-t1x9gknd 5002 23 to to TO cord-010119-t1x9gknd 5002 24 recruit recruit VB cord-010119-t1x9gknd 5002 25 new new JJ cord-010119-t1x9gknd 5002 26 AP AP NNP cord-010119-t1x9gknd 5002 27 donors donor NNS cord-010119-t1x9gknd 5002 28 and and CC cord-010119-t1x9gknd 5002 29 retention retention VB cord-010119-t1x9gknd 5002 30 them -PRON- PRP cord-010119-t1x9gknd 5002 31 as as IN cord-010119-t1x9gknd 5002 32 frequency frequency NN cord-010119-t1x9gknd 5002 33 AP AP NNP cord-010119-t1x9gknd 5002 34 donors donor NNS cord-010119-t1x9gknd 5002 35 in in IN cord-010119-t1x9gknd 5002 36 China China NNP cord-010119-t1x9gknd 5002 37 . . . cord-010119-t1x9gknd 5003 1 Study Study NNP cord-010119-t1x9gknd 5003 2 Design Design NNP cord-010119-t1x9gknd 5003 3 / / SYM cord-010119-t1x9gknd 5003 4 Method method NN cord-010119-t1x9gknd 5003 5 : : : cord-010119-t1x9gknd 5004 1 One one CD cord-010119-t1x9gknd 5004 2 stratified stratified JJ cord-010119-t1x9gknd 5004 3 recruitment recruitment NN cord-010119-t1x9gknd 5004 4 and and CC cord-010119-t1x9gknd 5004 5 retention retention NN cord-010119-t1x9gknd 5004 6 strategy strategy NN cord-010119-t1x9gknd 5004 7 established establish VBN cord-010119-t1x9gknd 5004 8 and and CC cord-010119-t1x9gknd 5004 9 applicate applicate NN cord-010119-t1x9gknd 5004 10 at at IN cord-010119-t1x9gknd 5004 11 Wuhan Wuhan NNP cord-010119-t1x9gknd 5004 12 blood blood NN cord-010119-t1x9gknd 5004 13 center center NN cord-010119-t1x9gknd 5004 14 since since IN cord-010119-t1x9gknd 5004 15 2006 2006 CD cord-010119-t1x9gknd 5004 16 . . . cord-010119-t1x9gknd 5005 1 Firstly firstly RB cord-010119-t1x9gknd 5005 2 , , , cord-010119-t1x9gknd 5005 3 " " `` cord-010119-t1x9gknd 5005 4 one one CD cord-010119-t1x9gknd 5005 5 - - HYPH cord-010119-t1x9gknd 5005 6 to to IN cord-010119-t1x9gknd 5005 7 - - HYPH cord-010119-t1x9gknd 5005 8 one one NN cord-010119-t1x9gknd 5005 9 " " '' cord-010119-t1x9gknd 5005 10 telephoning telephoning NN cord-010119-t1x9gknd 5005 11 model model NN cord-010119-t1x9gknd 5005 12 for for IN cord-010119-t1x9gknd 5005 13 whole whole JJ cord-010119-t1x9gknd 5005 14 blood blood NN cord-010119-t1x9gknd 5005 15 donors donor NNS cord-010119-t1x9gknd 5005 16 instead instead RB cord-010119-t1x9gknd 5005 17 to to TO cord-010119-t1x9gknd 5005 18 donate donate VB cord-010119-t1x9gknd 5005 19 platelet platelet NN cord-010119-t1x9gknd 5005 20 ; ; . cord-010119-t1x9gknd 5005 21 Secondly secondly RB cord-010119-t1x9gknd 5005 22 , , , cord-010119-t1x9gknd 5005 23 group group NN cord-010119-t1x9gknd 5005 24 message message NN cord-010119-t1x9gknd 5005 25 for for IN cord-010119-t1x9gknd 5005 26 permanent permanent JJ cord-010119-t1x9gknd 5005 27 AP AP NNP cord-010119-t1x9gknd 5005 28 donors donor NNS cord-010119-t1x9gknd 5005 29 and and CC cord-010119-t1x9gknd 5005 30 had have VBD cord-010119-t1x9gknd 5005 31 not not RB cord-010119-t1x9gknd 5005 32 donated donate VBN cord-010119-t1x9gknd 5005 33 with with IN cord-010119-t1x9gknd 5005 34 an an DT cord-010119-t1x9gknd 5005 35 interval interval NN cord-010119-t1x9gknd 5005 36 of of IN cord-010119-t1x9gknd 5005 37 more more JJR cord-010119-t1x9gknd 5005 38 than than IN cord-010119-t1x9gknd 5005 39 180 180 CD cord-010119-t1x9gknd 5005 40 days day NNS cord-010119-t1x9gknd 5005 41 in in IN cord-010119-t1x9gknd 5005 42 low low JJ cord-010119-t1x9gknd 5005 43 inventory inventory NN cord-010119-t1x9gknd 5005 44 . . . cord-010119-t1x9gknd 5006 1 Thirdly thirdly RB cord-010119-t1x9gknd 5006 2 , , , cord-010119-t1x9gknd 5006 3 specific specific JJ cord-010119-t1x9gknd 5006 4 recruiter recruiter NN cord-010119-t1x9gknd 5006 5 telephone telephone NN cord-010119-t1x9gknd 5006 6 for for IN cord-010119-t1x9gknd 5006 7 those those DT cord-010119-t1x9gknd 5006 8 AP AP NNP cord-010119-t1x9gknd 5006 9 donors donor NNS cord-010119-t1x9gknd 5006 10 who who WP cord-010119-t1x9gknd 5006 11 had have VBD cord-010119-t1x9gknd 5006 12 donated donate VBN cord-010119-t1x9gknd 5006 13 APs APs NNP cord-010119-t1x9gknd 5006 14 for for IN cord-010119-t1x9gknd 5006 15 more more JJR cord-010119-t1x9gknd 5006 16 than than IN cord-010119-t1x9gknd 5006 17 4 4 CD cord-010119-t1x9gknd 5006 18 times time NNS cord-010119-t1x9gknd 5006 19 and and CC cord-010119-t1x9gknd 5006 20 had have VBD cord-010119-t1x9gknd 5006 21 not not RB cord-010119-t1x9gknd 5006 22 donated donate VBN cord-010119-t1x9gknd 5006 23 for for IN cord-010119-t1x9gknd 5006 24 more more JJR cord-010119-t1x9gknd 5006 25 than than IN cord-010119-t1x9gknd 5006 26 90 90 CD cord-010119-t1x9gknd 5006 27 days day NNS cord-010119-t1x9gknd 5006 28 or or CC cord-010119-t1x9gknd 5006 29 less less JJR cord-010119-t1x9gknd 5006 30 than than IN cord-010119-t1x9gknd 5006 31 4 4 CD cord-010119-t1x9gknd 5006 32 times time NNS cord-010119-t1x9gknd 5006 33 with with IN cord-010119-t1x9gknd 5006 34 an an DT cord-010119-t1x9gknd 5006 35 interval interval NN cord-010119-t1x9gknd 5006 36 of of IN cord-010119-t1x9gknd 5006 37 more more JJR cord-010119-t1x9gknd 5006 38 than than IN cord-010119-t1x9gknd 5006 39 60 60 CD cord-010119-t1x9gknd 5006 40 days day NNS cord-010119-t1x9gknd 5006 41 from from IN cord-010119-t1x9gknd 5006 42 the the DT cord-010119-t1x9gknd 5006 43 last last JJ cord-010119-t1x9gknd 5006 44 donation donation NN cord-010119-t1x9gknd 5006 45 ; ; : cord-010119-t1x9gknd 5006 46 The the DT cord-010119-t1x9gknd 5006 47 last last JJ cord-010119-t1x9gknd 5006 48 one one NN cord-010119-t1x9gknd 5006 49 is be VBZ cord-010119-t1x9gknd 5006 50 preparing prepare VBG cord-010119-t1x9gknd 5006 51 one one CD cord-010119-t1x9gknd 5006 52 letter letter NN cord-010119-t1x9gknd 5006 53 of of IN cord-010119-t1x9gknd 5006 54 thanks thank NNS cord-010119-t1x9gknd 5006 55 for for IN cord-010119-t1x9gknd 5006 56 those those DT cord-010119-t1x9gknd 5006 57 AP AP NNP cord-010119-t1x9gknd 5006 58 donors donor NNS cord-010119-t1x9gknd 5006 59 who who WP cord-010119-t1x9gknd 5006 60 gave give VBD cord-010119-t1x9gknd 5006 61 more more JJR cord-010119-t1x9gknd 5006 62 than than IN cord-010119-t1x9gknd 5006 63 8 8 CD cord-010119-t1x9gknd 5006 64 times time NNS cord-010119-t1x9gknd 5006 65 annually annually RB cord-010119-t1x9gknd 5006 66 which which WDT cord-010119-t1x9gknd 5006 67 advise advise VBP cord-010119-t1x9gknd 5006 68 them -PRON- PRP cord-010119-t1x9gknd 5006 69 to to TO cord-010119-t1x9gknd 5006 70 voluntarily voluntarily RB cord-010119-t1x9gknd 5006 71 come come VB cord-010119-t1x9gknd 5006 72 to to IN cord-010119-t1x9gknd 5006 73 the the DT cord-010119-t1x9gknd 5006 74 blood blood NN cord-010119-t1x9gknd 5006 75 center center NN cord-010119-t1x9gknd 5006 76 for for IN cord-010119-t1x9gknd 5006 77 AP AP NNP cord-010119-t1x9gknd 5006 78 donation donation NN cord-010119-t1x9gknd 5006 79 when when WRB cord-010119-t1x9gknd 5006 80 they -PRON- PRP cord-010119-t1x9gknd 5006 81 were be VBD cord-010119-t1x9gknd 5006 82 available available JJ cord-010119-t1x9gknd 5006 83 . . . cord-010119-t1x9gknd 5007 1 Results/ Results/ . cord-010119-t1x9gknd 5008 1 Finding finding NN cord-010119-t1x9gknd 5008 2 : : : cord-010119-t1x9gknd 5009 1 Over over IN cord-010119-t1x9gknd 5009 2 the the DT cord-010119-t1x9gknd 5009 3 past past JJ cord-010119-t1x9gknd 5009 4 decade decade NN cord-010119-t1x9gknd 5009 5 , , , cord-010119-t1x9gknd 5009 6 the the DT cord-010119-t1x9gknd 5009 7 overall overall JJ cord-010119-t1x9gknd 5009 8 donation donation NN cord-010119-t1x9gknd 5009 9 time time NN cord-010119-t1x9gknd 5009 10 of of IN cord-010119-t1x9gknd 5009 11 AP AP NNP cord-010119-t1x9gknd 5009 12 donors donor NNS cord-010119-t1x9gknd 5009 13 increased increase VBD cord-010119-t1x9gknd 5009 14 by by IN cord-010119-t1x9gknd 5009 15 7.46 7.46 CD cord-010119-t1x9gknd 5009 16 times time NNS cord-010119-t1x9gknd 5009 17 from from IN cord-010119-t1x9gknd 5009 18 5550 5550 CD cord-010119-t1x9gknd 5009 19 to to IN cord-010119-t1x9gknd 5009 20 41420 41420 CD cord-010119-t1x9gknd 5009 21 and and CC cord-010119-t1x9gknd 5009 22 the the DT cord-010119-t1x9gknd 5009 23 doses dose NNS cord-010119-t1x9gknd 5009 24 of of IN cord-010119-t1x9gknd 5009 25 AP AP NNP cord-010119-t1x9gknd 5009 26 increased increase VBD cord-010119-t1x9gknd 5009 27 by by IN cord-010119-t1x9gknd 5009 28 7.41 7.41 CD cord-010119-t1x9gknd 5009 29 times time NNS cord-010119-t1x9gknd 5009 30 from from IN cord-010119-t1x9gknd 5009 31 7363 7363 CD cord-010119-t1x9gknd 5009 32 to to IN cord-010119-t1x9gknd 5009 33 54553 54553 CD cord-010119-t1x9gknd 5009 34 within within IN cord-010119-t1x9gknd 5009 35 10 10 CD cord-010119-t1x9gknd 5009 36 years year NNS cord-010119-t1x9gknd 5009 37 . . . cord-010119-t1x9gknd 5010 1 The the DT cord-010119-t1x9gknd 5010 2 APs aps NN cord-010119-t1x9gknd 5010 3 collected collect VBD cord-010119-t1x9gknd 5010 4 fulfilled fulfil VBD cord-010119-t1x9gknd 5010 5 the the DT cord-010119-t1x9gknd 5010 6 clinical clinical JJ cord-010119-t1x9gknd 5010 7 needs need NNS cord-010119-t1x9gknd 5010 8 . . . cord-010119-t1x9gknd 5011 1 According accord VBG cord-010119-t1x9gknd 5011 2 to to IN cord-010119-t1x9gknd 5011 3 the the DT cord-010119-t1x9gknd 5011 4 donation donation NN cord-010119-t1x9gknd 5011 5 frequency frequency NN cord-010119-t1x9gknd 5011 6 , , , cord-010119-t1x9gknd 5011 7 AP AP NNP cord-010119-t1x9gknd 5011 8 donors donor NNS cord-010119-t1x9gknd 5011 9 were be VBD cord-010119-t1x9gknd 5011 10 divided divide VBN cord-010119-t1x9gknd 5011 11 into into IN cord-010119-t1x9gknd 5011 12 5 5 CD cord-010119-t1x9gknd 5011 13 groups group NNS cord-010119-t1x9gknd 5011 14 : : : cord-010119-t1x9gknd 5011 15 those those DT cord-010119-t1x9gknd 5011 16 who who WP cord-010119-t1x9gknd 5011 17 donated donate VBD cord-010119-t1x9gknd 5011 18 AP AP NNP cord-010119-t1x9gknd 5011 19 once once RB cord-010119-t1x9gknd 5011 20 , , , cord-010119-t1x9gknd 5011 21 those those DT cord-010119-t1x9gknd 5011 22 who who WP cord-010119-t1x9gknd 5011 23 donated donate VBD cord-010119-t1x9gknd 5011 24 2 2 CD cord-010119-t1x9gknd 5011 25 - - SYM cord-010119-t1x9gknd 5011 26 4 4 CD cord-010119-t1x9gknd 5011 27 times time NNS cord-010119-t1x9gknd 5011 28 , , , cord-010119-t1x9gknd 5011 29 5 5 CD cord-010119-t1x9gknd 5011 30 - - SYM cord-010119-t1x9gknd 5011 31 9 9 CD cord-010119-t1x9gknd 5011 32 times time NNS cord-010119-t1x9gknd 5011 33 , , , cord-010119-t1x9gknd 5011 34 10 10 CD cord-010119-t1x9gknd 5011 35 - - SYM cord-010119-t1x9gknd 5011 36 29 29 CD cord-010119-t1x9gknd 5011 37 times time NNS cord-010119-t1x9gknd 5011 38 , , , cord-010119-t1x9gknd 5011 39 and and CC cord-010119-t1x9gknd 5011 40 those those DT cord-010119-t1x9gknd 5011 41 who who WP cord-010119-t1x9gknd 5011 42 donated donate VBD cord-010119-t1x9gknd 5011 43 more more JJR cord-010119-t1x9gknd 5011 44 than than IN cord-010119-t1x9gknd 5011 45 30 30 CD cord-010119-t1x9gknd 5011 46 times time NNS cord-010119-t1x9gknd 5011 47 , , , cord-010119-t1x9gknd 5011 48 respectively respectively RB cord-010119-t1x9gknd 5011 49 . . . cord-010119-t1x9gknd 5012 1 It -PRON- PRP cord-010119-t1x9gknd 5012 2 was be VBD cord-010119-t1x9gknd 5012 3 found find VBN cord-010119-t1x9gknd 5012 4 that that IN cord-010119-t1x9gknd 5012 5 the the DT cord-010119-t1x9gknd 5012 6 number number NN cord-010119-t1x9gknd 5012 7 of of IN cord-010119-t1x9gknd 5012 8 permanent permanent JJ cord-010119-t1x9gknd 5012 9 AP AP NNP cord-010119-t1x9gknd 5012 10 donors donor NNS cord-010119-t1x9gknd 5012 11 who who WP cord-010119-t1x9gknd 5012 12 donated donate VBD cord-010119-t1x9gknd 5012 13 AP AP NNP cord-010119-t1x9gknd 5012 14 more more JJR cord-010119-t1x9gknd 5012 15 than than IN cord-010119-t1x9gknd 5012 16 30 30 CD cord-010119-t1x9gknd 5012 17 times time NNS cord-010119-t1x9gknd 5012 18 was be VBD cord-010119-t1x9gknd 5012 19 only only RB cord-010119-t1x9gknd 5012 20 965 965 CD cord-010119-t1x9gknd 5012 21 ( ( -LRB- cord-010119-t1x9gknd 5012 22 2.1 2.1 CD cord-010119-t1x9gknd 5012 23 % % NN cord-010119-t1x9gknd 5012 24 ) ) -RRB- cord-010119-t1x9gknd 5012 25 , , , cord-010119-t1x9gknd 5012 26 but but CC cord-010119-t1x9gknd 5012 27 they -PRON- PRP cord-010119-t1x9gknd 5012 28 denoted denote VBD cord-010119-t1x9gknd 5012 29 a a DT cord-010119-t1x9gknd 5012 30 total total NN cord-010119-t1x9gknd 5012 31 of of IN cord-010119-t1x9gknd 5012 32 76432 76432 CD cord-010119-t1x9gknd 5012 33 doses dose NNS cord-010119-t1x9gknd 5012 34 of of IN cord-010119-t1x9gknd 5012 35 AP AP NNP cord-010119-t1x9gknd 5012 36 ( ( -LRB- cord-010119-t1x9gknd 5012 37 29.2 29.2 CD cord-010119-t1x9gknd 5012 38 % % NN cord-010119-t1x9gknd 5012 39 ) ) -RRB- cord-010119-t1x9gknd 5012 40 from from IN cord-010119-t1x9gknd 5012 41 2006 2006 CD cord-010119-t1x9gknd 5012 42 to to IN cord-010119-t1x9gknd 5012 43 2016 2016 CD cord-010119-t1x9gknd 5012 44 . . . cord-010119-t1x9gknd 5013 1 Conclusion conclusion NN cord-010119-t1x9gknd 5013 2 : : : cord-010119-t1x9gknd 5013 3 APs APs NNP cord-010119-t1x9gknd 5013 4 increased increase VBD cord-010119-t1x9gknd 5013 5 at at IN cord-010119-t1x9gknd 5013 6 a a DT cord-010119-t1x9gknd 5013 7 rapid rapid JJ cord-010119-t1x9gknd 5013 8 and and CC cord-010119-t1x9gknd 5013 9 steady steady JJ cord-010119-t1x9gknd 5013 10 pace pace NN cord-010119-t1x9gknd 5013 11 in in IN cord-010119-t1x9gknd 5013 12 Wuhan Wuhan NNP cord-010119-t1x9gknd 5013 13 blood blood NN cord-010119-t1x9gknd 5013 14 center center NN cord-010119-t1x9gknd 5013 15 from from IN cord-010119-t1x9gknd 5013 16 2006 2006 CD cord-010119-t1x9gknd 5013 17 to to IN cord-010119-t1x9gknd 5013 18 2016 2016 CD cord-010119-t1x9gknd 5013 19 , , , cord-010119-t1x9gknd 5013 20 which which WDT cord-010119-t1x9gknd 5013 21 not not RB cord-010119-t1x9gknd 5013 22 only only RB cord-010119-t1x9gknd 5013 23 met meet VBD cord-010119-t1x9gknd 5013 24 the the DT cord-010119-t1x9gknd 5013 25 clinical clinical JJ cord-010119-t1x9gknd 5013 26 needs need NNS cord-010119-t1x9gknd 5013 27 but but CC cord-010119-t1x9gknd 5013 28 also also RB cord-010119-t1x9gknd 5013 29 were be VBD cord-010119-t1x9gknd 5013 30 supplied supply VBN cord-010119-t1x9gknd 5013 31 to to IN cord-010119-t1x9gknd 5013 32 other other JJ cord-010119-t1x9gknd 5013 33 region region NN cord-010119-t1x9gknd 5013 34 outside outside IN cord-010119-t1x9gknd 5013 35 Wuhan Wuhan NNP cord-010119-t1x9gknd 5013 36 . . . cord-010119-t1x9gknd 5014 1 And and CC cord-010119-t1x9gknd 5014 2 in in IN cord-010119-t1x9gknd 5014 3 addition addition NN cord-010119-t1x9gknd 5014 4 , , , cord-010119-t1x9gknd 5014 5 the the DT cord-010119-t1x9gknd 5014 6 permanent permanent JJ cord-010119-t1x9gknd 5014 7 AP AP NNP cord-010119-t1x9gknd 5014 8 donors donor NNS cord-010119-t1x9gknd 5014 9 who who WP cord-010119-t1x9gknd 5014 10 gained gain VBD cord-010119-t1x9gknd 5014 11 more more JJR cord-010119-t1x9gknd 5014 12 attention attention NN cord-010119-t1x9gknd 5014 13 donated donate VBD cord-010119-t1x9gknd 5014 14 the the DT cord-010119-t1x9gknd 5014 15 greatest great JJS cord-010119-t1x9gknd 5014 16 percentage percentage NN cord-010119-t1x9gknd 5014 17 of of IN cord-010119-t1x9gknd 5014 18 platelets platelet NNS cord-010119-t1x9gknd 5014 19 . . . cord-010119-t1x9gknd 5015 1 In in IN cord-010119-t1x9gknd 5015 2 conclusion conclusion NN cord-010119-t1x9gknd 5015 3 , , , cord-010119-t1x9gknd 5015 4 stratified stratified JJ cord-010119-t1x9gknd 5015 5 recruitment recruitment NN cord-010119-t1x9gknd 5015 6 is be VBZ cord-010119-t1x9gknd 5015 7 one one CD cord-010119-t1x9gknd 5015 8 effective effective JJ cord-010119-t1x9gknd 5015 9 approaches approach NNS cord-010119-t1x9gknd 5015 10 to to TO cord-010119-t1x9gknd 5015 11 meet meet VB cord-010119-t1x9gknd 5015 12 clinical clinical JJ cord-010119-t1x9gknd 5015 13 needs need NNS cord-010119-t1x9gknd 5015 14 for for IN cord-010119-t1x9gknd 5015 15 platelets platelet NNS cord-010119-t1x9gknd 5015 16 and and CC cord-010119-t1x9gknd 5015 17 worth worth JJ cord-010119-t1x9gknd 5015 18 to to TO cord-010119-t1x9gknd 5015 19 popularize popularize VB cord-010119-t1x9gknd 5015 20 to to IN cord-010119-t1x9gknd 5015 21 other other JJ cord-010119-t1x9gknd 5015 22 region region NN cord-010119-t1x9gknd 5015 23 . . . cord-010119-t1x9gknd 5016 1 years year NNS cord-010119-t1x9gknd 5016 2 were be VBD cord-010119-t1x9gknd 5016 3 evaluated evaluate VBN cord-010119-t1x9gknd 5016 4 at at IN cord-010119-t1x9gknd 5016 5 4 4 CD cord-010119-t1x9gknd 5016 6 sites site NNS cord-010119-t1x9gknd 5016 7 on on IN cord-010119-t1x9gknd 5016 8 2 2 CD cord-010119-t1x9gknd 5016 9 consecutive consecutive JJ cord-010119-t1x9gknd 5016 10 donations donation NNS cord-010119-t1x9gknd 5016 11 for for IN cord-010119-t1x9gknd 5016 12 finger finger NN cord-010119-t1x9gknd 5016 13 stick stick NNP cord-010119-t1x9gknd 5016 14 ( ( -LRB- cord-010119-t1x9gknd 5016 15 fs f NNS cord-010119-t1x9gknd 5016 16 ) ) -RRB- cord-010119-t1x9gknd 5016 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5016 18 ( ( -LRB- cord-010119-t1x9gknd 5016 19 HB HB NNP cord-010119-t1x9gknd 5016 20 ) ) -RRB- cord-010119-t1x9gknd 5016 21 per per IN cord-010119-t1x9gknd 5016 22 site site NN cord-010119-t1x9gknd 5016 23 policy policy NN cord-010119-t1x9gknd 5016 24 . . . cord-010119-t1x9gknd 5017 1 Venous venous JJ cord-010119-t1x9gknd 5017 2 ( ( -LRB- cord-010119-t1x9gknd 5017 3 ven ven NNP cord-010119-t1x9gknd 5017 4 ) ) -RRB- cord-010119-t1x9gknd 5017 5 and and CC cord-010119-t1x9gknd 5017 6 capillary capillary JJ cord-010119-t1x9gknd 5017 7 ( ( -LRB- cord-010119-t1x9gknd 5017 8 cap cap NN cord-010119-t1x9gknd 5017 9 ) ) -RRB- cord-010119-t1x9gknd 5017 10 ZPP ZPP NNP cord-010119-t1x9gknd 5017 11 and and CC cord-010119-t1x9gknd 5017 12 ven ven NNP cord-010119-t1x9gknd 5017 13 ferritin ferritin NN cord-010119-t1x9gknd 5017 14 ( ( -LRB- cord-010119-t1x9gknd 5017 15 Fer Fer NNP cord-010119-t1x9gknd 5017 16 ) ) -RRB- cord-010119-t1x9gknd 5017 17 were be VBD cord-010119-t1x9gknd 5017 18 performed perform VBN cord-010119-t1x9gknd 5017 19 per per IN cord-010119-t1x9gknd 5017 20 manufacturers manufacturer NNS cord-010119-t1x9gknd 5017 21 ' ' POS cord-010119-t1x9gknd 5017 22 direction direction NN cord-010119-t1x9gknd 5017 23 . . . cord-010119-t1x9gknd 5018 1 Donors donor NNS cord-010119-t1x9gknd 5018 2 were be VBD cord-010119-t1x9gknd 5018 3 assessed assess VBN cord-010119-t1x9gknd 5018 4 for for IN cord-010119-t1x9gknd 5018 5 subclinical subclinical JJ cord-010119-t1x9gknd 5018 6 iron iron NN cord-010119-t1x9gknd 5018 7 deficiency deficiency NN cord-010119-t1x9gknd 5018 8 using use VBG cord-010119-t1x9gknd 5018 9 ranges range NNS cord-010119-t1x9gknd 5018 10 ( ( -LRB- cord-010119-t1x9gknd 5018 11 Fer Fer NNP cord-010119-t1x9gknd 5018 12 < < XX cord-010119-t1x9gknd 5018 13 26 26 CD cord-010119-t1x9gknd 5018 14 ng ng NN cord-010119-t1x9gknd 5018 15 / / SYM cord-010119-t1x9gknd 5018 16 mL ml NN cord-010119-t1x9gknd 5018 17 and and CC cord-010119-t1x9gknd 5018 18 ZPP ZPP NNP cord-010119-t1x9gknd 5018 19 levels level NNS cord-010119-t1x9gknd 5018 20 > > NFP cord-010119-t1x9gknd 5018 21 100 100 CD cord-010119-t1x9gknd 5018 22 umol umol JJ cord-010119-t1x9gknd 5018 23 / / SYM cord-010119-t1x9gknd 5018 24 mol mol NN cord-010119-t1x9gknd 5018 25 heme heme NN cord-010119-t1x9gknd 5018 26 ) ) -RRB- cord-010119-t1x9gknd 5018 27 at at IN cord-010119-t1x9gknd 5018 28 3 3 CD cord-010119-t1x9gknd 5018 29 HB HB NNP cord-010119-t1x9gknd 5018 30 levels level NNS cord-010119-t1x9gknd 5018 31 . . . cord-010119-t1x9gknd 5019 1 Participants participant NNS cord-010119-t1x9gknd 5019 2 completed complete VBD cord-010119-t1x9gknd 5019 3 an an DT cord-010119-t1x9gknd 5019 4 online online JJ cord-010119-t1x9gknd 5019 5 survey survey NN cord-010119-t1x9gknd 5019 6 between between IN cord-010119-t1x9gknd 5019 7 donations donation NNS cord-010119-t1x9gknd 5019 8 to to TO cord-010119-t1x9gknd 5019 9 collect collect VB cord-010119-t1x9gknd 5019 10 data datum NNS cord-010119-t1x9gknd 5019 11 on on IN cord-010119-t1x9gknd 5019 12 symptoms symptom NNS cord-010119-t1x9gknd 5019 13 of of IN cord-010119-t1x9gknd 5019 14 anemia anemia NN cord-010119-t1x9gknd 5019 15 . . . cord-010119-t1x9gknd 5020 1 Univariate Univariate NNP cord-010119-t1x9gknd 5020 2 linear linear JJ cord-010119-t1x9gknd 5020 3 regression regression NN cord-010119-t1x9gknd 5020 4 analysis analysis NN cord-010119-t1x9gknd 5020 5 was be VBD cord-010119-t1x9gknd 5020 6 used use VBN cord-010119-t1x9gknd 5020 7 to to TO cord-010119-t1x9gknd 5020 8 determine determine VB cord-010119-t1x9gknd 5020 9 relationship relationship NN cord-010119-t1x9gknd 5020 10 between between IN cord-010119-t1x9gknd 5020 11 tests test NNS cord-010119-t1x9gknd 5020 12 . . . cord-010119-t1x9gknd 5021 1 Results result NNS cord-010119-t1x9gknd 5022 1 /Finding /finde VBG cord-010119-t1x9gknd 5022 2 : : : cord-010119-t1x9gknd 5023 1 Subclinical Subclinical NNP cord-010119-t1x9gknd 5023 2 iron iron NN cord-010119-t1x9gknd 5023 3 deficiency deficiency NN cord-010119-t1x9gknd 5023 4 was be VBD cord-010119-t1x9gknd 5023 5 present present JJ cord-010119-t1x9gknd 5023 6 among among IN cord-010119-t1x9gknd 5023 7 first first JJ cord-010119-t1x9gknd 5023 8 - - HYPH cord-010119-t1x9gknd 5023 9 time time NN cord-010119-t1x9gknd 5023 10 and and CC cord-010119-t1x9gknd 5023 11 repeat repeat VB cord-010119-t1x9gknd 5023 12 blood blood NN cord-010119-t1x9gknd 5023 13 donors donor NNS cord-010119-t1x9gknd 5023 14 at at IN cord-010119-t1x9gknd 5023 15 all all RB cord-010119-t1x9gknd 5023 16 3 3 CD cord-010119-t1x9gknd 5023 17 HB HB NNP cord-010119-t1x9gknd 5023 18 levels level NNS cord-010119-t1x9gknd 5023 19 with with IN cord-010119-t1x9gknd 5023 20 both both DT cord-010119-t1x9gknd 5023 21 genders gender NNS cord-010119-t1x9gknd 5023 22 and and CC cord-010119-t1x9gknd 5023 23 all all DT cord-010119-t1x9gknd 5023 24 age age NN cord-010119-t1x9gknd 5023 25 groups group NNS cord-010119-t1x9gknd 5023 26 . . . cord-010119-t1x9gknd 5024 1 ( ( -LRB- cord-010119-t1x9gknd 5024 2 Table table NN cord-010119-t1x9gknd 5024 3 ) ) -RRB- cord-010119-t1x9gknd 5025 1 There there EX cord-010119-t1x9gknd 5025 2 was be VBD cord-010119-t1x9gknd 5025 3 a a DT cord-010119-t1x9gknd 5025 4 highly highly RB cord-010119-t1x9gknd 5025 5 significant significant JJ cord-010119-t1x9gknd 5025 6 correlation correlation NN cord-010119-t1x9gknd 5025 7 between between IN cord-010119-t1x9gknd 5025 8 fs f NNS cord-010119-t1x9gknd 5025 9 ZPP ZPP NNP cord-010119-t1x9gknd 5025 10 and and CC cord-010119-t1x9gknd 5025 11 ven ven NNP cord-010119-t1x9gknd 5025 12 ZPP ZPP NNP cord-010119-t1x9gknd 5025 13 87.8 87.8 CD cord-010119-t1x9gknd 5025 14 % % NN cord-010119-t1x9gknd 5025 15 ( ( -LRB- cord-010119-t1x9gknd 5025 16 R50.937 r50.937 NN cord-010119-t1x9gknd 5025 17 ) ) -RRB- cord-010119-t1x9gknd 5025 18 at at IN cord-010119-t1x9gknd 5025 19 first first JJ cord-010119-t1x9gknd 5025 20 and and CC cord-010119-t1x9gknd 5025 21 86.5 86.5 CD cord-010119-t1x9gknd 5025 22 % % NN cord-010119-t1x9gknd 5025 23 ( ( -LRB- cord-010119-t1x9gknd 5025 24 R50.93 r50.93 LS cord-010119-t1x9gknd 5025 25 ) ) -RRB- cord-010119-t1x9gknd 5025 26 at at IN cord-010119-t1x9gknd 5025 27 second second JJ cord-010119-t1x9gknd 5025 28 donations donation NNS cord-010119-t1x9gknd 5025 29 . . . cord-010119-t1x9gknd 5026 1 At at IN cord-010119-t1x9gknd 5026 2 first first JJ cord-010119-t1x9gknd 5026 3 donation donation NN cord-010119-t1x9gknd 5026 4 when when WRB cord-010119-t1x9gknd 5026 5 compared compare VBN cord-010119-t1x9gknd 5026 6 to to IN cord-010119-t1x9gknd 5026 7 fs f NNS cord-010119-t1x9gknd 5026 8 HB HB NNP cord-010119-t1x9gknd 5026 9 , , , cord-010119-t1x9gknd 5026 10 only only RB cord-010119-t1x9gknd 5026 11 10.4 10.4 CD cord-010119-t1x9gknd 5026 12 % % NN cord-010119-t1x9gknd 5026 13 ( ( -LRB- cord-010119-t1x9gknd 5026 14 R50.323 r50.323 NN cord-010119-t1x9gknd 5026 15 ) ) -RRB- cord-010119-t1x9gknd 5026 16 of of IN cord-010119-t1x9gknd 5026 17 variation variation NN cord-010119-t1x9gknd 5026 18 could could MD cord-010119-t1x9gknd 5026 19 be be VB cord-010119-t1x9gknd 5026 20 explained explain VBN cord-010119-t1x9gknd 5026 21 by by IN cord-010119-t1x9gknd 5026 22 variation variation NN cord-010119-t1x9gknd 5026 23 in in IN cord-010119-t1x9gknd 5026 24 fs f NNS cord-010119-t1x9gknd 5026 25 ZPP ZPP NNP cord-010119-t1x9gknd 5026 26 , , , cord-010119-t1x9gknd 5026 27 12.3 12.3 CD cord-010119-t1x9gknd 5026 28 % % NN cord-010119-t1x9gknd 5026 29 ( ( -LRB- cord-010119-t1x9gknd 5026 30 R50.35 r50.35 CD cord-010119-t1x9gknd 5026 31 ) ) -RRB- cord-010119-t1x9gknd 5026 32 by by IN cord-010119-t1x9gknd 5026 33 ven ven NNP cord-010119-t1x9gknd 5026 34 ZPP ZPP NNP cord-010119-t1x9gknd 5026 35 and and CC cord-010119-t1x9gknd 5026 36 9.4 9.4 CD cord-010119-t1x9gknd 5026 37 % % NN cord-010119-t1x9gknd 5026 38 ( ( -LRB- cord-010119-t1x9gknd 5026 39 R50.307 r50.307 NN cord-010119-t1x9gknd 5026 40 ) ) -RRB- cord-010119-t1x9gknd 5026 41 by by IN cord-010119-t1x9gknd 5026 42 ven ven NNP cord-010119-t1x9gknd 5026 43 Fer Fer NNP cord-010119-t1x9gknd 5026 44 . . . cord-010119-t1x9gknd 5027 1 At at IN cord-010119-t1x9gknd 5027 2 second second JJ cord-010119-t1x9gknd 5027 3 donation donation NN cord-010119-t1x9gknd 5027 4 , , , cord-010119-t1x9gknd 5027 5 when when WRB cord-010119-t1x9gknd 5027 6 compared compare VBN cord-010119-t1x9gknd 5027 7 to to IN cord-010119-t1x9gknd 5027 8 fs f NNS cord-010119-t1x9gknd 5027 9 HB HB NNP cord-010119-t1x9gknd 5027 10 , , , cord-010119-t1x9gknd 5027 11 only only RB cord-010119-t1x9gknd 5027 12 9 9 CD cord-010119-t1x9gknd 5027 13 % % NN cord-010119-t1x9gknd 5027 14 ( ( -LRB- cord-010119-t1x9gknd 5027 15 R50.30 R50.30 NNP cord-010119-t1x9gknd 5027 16 ) ) -RRB- cord-010119-t1x9gknd 5027 17 of of IN cord-010119-t1x9gknd 5027 18 variation variation NN cord-010119-t1x9gknd 5027 19 could could MD cord-010119-t1x9gknd 5027 20 be be VB cord-010119-t1x9gknd 5027 21 explained explain VBN cord-010119-t1x9gknd 5027 22 by by IN cord-010119-t1x9gknd 5027 23 variation variation NN cord-010119-t1x9gknd 5027 24 in in IN cord-010119-t1x9gknd 5027 25 fs f NNS cord-010119-t1x9gknd 5027 26 ZPP ZPP NNP cord-010119-t1x9gknd 5027 27 , , , cord-010119-t1x9gknd 5027 28 14.4 14.4 CD cord-010119-t1x9gknd 5027 29 % % NN cord-010119-t1x9gknd 5027 30 ( ( -LRB- cord-010119-t1x9gknd 5027 31 R50.38 R50.38 NFP cord-010119-t1x9gknd 5027 32 ) ) -RRB- cord-010119-t1x9gknd 5027 33 by by IN cord-010119-t1x9gknd 5027 34 ven ven NNP cord-010119-t1x9gknd 5027 35 ZPP ZPP NNP cord-010119-t1x9gknd 5027 36 and and CC cord-010119-t1x9gknd 5027 37 20.1 20.1 CD cord-010119-t1x9gknd 5027 38 % % NN cord-010119-t1x9gknd 5027 39 ( ( -LRB- cord-010119-t1x9gknd 5027 40 R50.448 R50.448 NNP cord-010119-t1x9gknd 5027 41 ) ) -RRB- cord-010119-t1x9gknd 5027 42 by by IN cord-010119-t1x9gknd 5027 43 ven ven NNP cord-010119-t1x9gknd 5027 44 Fer Fer NNP cord-010119-t1x9gknd 5027 45 . . . cord-010119-t1x9gknd 5028 1 For for IN cord-010119-t1x9gknd 5028 2 each each DT cord-010119-t1x9gknd 5028 3 donation donation NN cord-010119-t1x9gknd 5028 4 , , , cord-010119-t1x9gknd 5028 5 variation variation NN cord-010119-t1x9gknd 5028 6 among among IN cord-010119-t1x9gknd 5028 7 tests test NNS cord-010119-t1x9gknd 5028 8 ( ( -LRB- cord-010119-t1x9gknd 5028 9 fs f NNS cord-010119-t1x9gknd 5028 10 HB HB NNP cord-010119-t1x9gknd 5028 11 , , , cord-010119-t1x9gknd 5028 12 ven ven NNP cord-010119-t1x9gknd 5028 13 Fer Fer NNP cord-010119-t1x9gknd 5028 14 , , , cord-010119-t1x9gknd 5028 15 ven ven NNP cord-010119-t1x9gknd 5028 16 ZPP ZPP NNP cord-010119-t1x9gknd 5028 17 and and CC cord-010119-t1x9gknd 5028 18 fs f NNS cord-010119-t1x9gknd 5028 19 ZPP ZPP NNP cord-010119-t1x9gknd 5028 20 ) ) -RRB- cord-010119-t1x9gknd 5028 21 was be VBD cord-010119-t1x9gknd 5028 22 significant significant JJ cord-010119-t1x9gknd 5028 23 ( ( -LRB- cord-010119-t1x9gknd 5028 24 p<0.001 p<0.001 JJ cord-010119-t1x9gknd 5028 25 ) ) -RRB- cord-010119-t1x9gknd 5028 26 suggesting suggest VBG cord-010119-t1x9gknd 5028 27 strong strong JJ cord-010119-t1x9gknd 5028 28 evidence evidence NN cord-010119-t1x9gknd 5028 29 against against IN cord-010119-t1x9gknd 5028 30 correlation correlation NN cord-010119-t1x9gknd 5028 31 . . . cord-010119-t1x9gknd 5029 1 55 55 CD cord-010119-t1x9gknd 5029 2 % % NN cord-010119-t1x9gknd 5029 3 ( ( -LRB- cord-010119-t1x9gknd 5029 4 181 181 CD cord-010119-t1x9gknd 5029 5 ) ) -RRB- cord-010119-t1x9gknd 5029 6 responded respond VBD cord-010119-t1x9gknd 5029 7 to to IN cord-010119-t1x9gknd 5029 8 the the DT cord-010119-t1x9gknd 5029 9 survey survey NN cord-010119-t1x9gknd 5029 10 of of IN cord-010119-t1x9gknd 5029 11 which which WDT cord-010119-t1x9gknd 5029 12 4 4 CD cord-010119-t1x9gknd 5029 13 % % NN cord-010119-t1x9gknd 5029 14 ( ( -LRB- cord-010119-t1x9gknd 5029 15 13 13 CD cord-010119-t1x9gknd 5029 16 ) ) -RRB- cord-010119-t1x9gknd 5029 17 reported report VBD cord-010119-t1x9gknd 5029 18 not not RB cord-010119-t1x9gknd 5029 19 feeling feel VBG cord-010119-t1x9gknd 5029 20 well well RB cord-010119-t1x9gknd 5029 21 after after IN cord-010119-t1x9gknd 5029 22 donation donation NN cord-010119-t1x9gknd 5029 23 . . . cord-010119-t1x9gknd 5030 1 It -PRON- PRP cord-010119-t1x9gknd 5030 2 should should MD cord-010119-t1x9gknd 5030 3 be be VB cord-010119-t1x9gknd 5030 4 noted note VBN cord-010119-t1x9gknd 5030 5 that that IN cord-010119-t1x9gknd 5030 6 noted note VBD cord-010119-t1x9gknd 5030 7 that that IN cord-010119-t1x9gknd 5030 8 1 1 CD cord-010119-t1x9gknd 5030 9 % % NN cord-010119-t1x9gknd 5030 10 ( ( -LRB- cord-010119-t1x9gknd 5030 11 3 3 CD cord-010119-t1x9gknd 5030 12 ) ) -RRB- cord-010119-t1x9gknd 5030 13 female female JJ cord-010119-t1x9gknd 5030 14 study study NN cord-010119-t1x9gknd 5030 15 participants participant NNS cord-010119-t1x9gknd 5030 16 reported report VBD cord-010119-t1x9gknd 5030 17 feeling feel VBG cord-010119-t1x9gknd 5030 18 unwell unwell JJ cord-010119-t1x9gknd 5030 19 after after IN cord-010119-t1x9gknd 5030 20 the the DT cord-010119-t1x9gknd 5030 21 first first JJ cord-010119-t1x9gknd 5030 22 donation donation NN cord-010119-t1x9gknd 5030 23 and and CC cord-010119-t1x9gknd 5030 24 had have VBD cord-010119-t1x9gknd 5030 25 ferritin ferritin NN cord-010119-t1x9gknd 5030 26 levels level NNS cord-010119-t1x9gknd 5030 27 below below IN cord-010119-t1x9gknd 5030 28 26ng 26ng JJ cord-010119-t1x9gknd 5030 29 / / SYM cord-010119-t1x9gknd 5030 30 mL ml NN cord-010119-t1x9gknd 5031 1 but but CC cord-010119-t1x9gknd 5031 2 the the DT cord-010119-t1x9gknd 5031 3 ZPP ZPP NNP cord-010119-t1x9gknd 5031 4 levels level NNS cord-010119-t1x9gknd 5031 5 were be VBD cord-010119-t1x9gknd 5031 6 less less JJR cord-010119-t1x9gknd 5031 7 than than IN cord-010119-t1x9gknd 5031 8 100 100 CD cord-010119-t1x9gknd 5031 9 umol umol JJ cord-010119-t1x9gknd 5031 10 / / SYM cord-010119-t1x9gknd 5031 11 mol mol NN cord-010119-t1x9gknd 5031 12 heme heme NN cord-010119-t1x9gknd 5031 13 . . . cord-010119-t1x9gknd 5032 1 Of of IN cord-010119-t1x9gknd 5032 2 the the DT cord-010119-t1x9gknd 5032 3 3 3 CD cord-010119-t1x9gknd 5032 4 % % NN cord-010119-t1x9gknd 5032 5 ( ( -LRB- cord-010119-t1x9gknd 5032 6 10 10 CD cord-010119-t1x9gknd 5032 7 ) ) -RRB- cord-010119-t1x9gknd 5032 8 male male JJ cord-010119-t1x9gknd 5032 9 participants participant NNS cord-010119-t1x9gknd 5032 10 that that WDT cord-010119-t1x9gknd 5032 11 reported report VBD cord-010119-t1x9gknd 5032 12 not not RB cord-010119-t1x9gknd 5032 13 feeling feel VBG cord-010119-t1x9gknd 5032 14 well well RB cord-010119-t1x9gknd 5033 1 none none NN cord-010119-t1x9gknd 5033 2 had have VBD cord-010119-t1x9gknd 5033 3 ferritin ferritin NN cord-010119-t1x9gknd 5033 4 levels level NNS cord-010119-t1x9gknd 5033 5 below below IN cord-010119-t1x9gknd 5033 6 26 26 CD cord-010119-t1x9gknd 5033 7 ng ng NN cord-010119-t1x9gknd 5033 8 / / SYM cord-010119-t1x9gknd 5033 9 mL mL NNP cord-010119-t1x9gknd 5033 10 nor nor CC cord-010119-t1x9gknd 5033 11 ven ven NN cord-010119-t1x9gknd 5033 12 or or CC cord-010119-t1x9gknd 5033 13 fs f NNS cord-010119-t1x9gknd 5033 14 ZPP ZPP NNP cord-010119-t1x9gknd 5033 15 levels level NNS cord-010119-t1x9gknd 5033 16 above above IN cord-010119-t1x9gknd 5033 17 100 100 CD cord-010119-t1x9gknd 5033 18 umol umol JJ cord-010119-t1x9gknd 5033 19 / / SYM cord-010119-t1x9gknd 5033 20 mol mol NN cord-010119-t1x9gknd 5033 21 heme heme NN cord-010119-t1x9gknd 5033 22 . . . cord-010119-t1x9gknd 5034 1 Conclusion conclusion NN cord-010119-t1x9gknd 5034 2 : : : cord-010119-t1x9gknd 5035 1 Subclinical Subclinical NNP cord-010119-t1x9gknd 5035 2 iron iron NN cord-010119-t1x9gknd 5035 3 deficiency deficiency NN cord-010119-t1x9gknd 5035 4 was be VBD cord-010119-t1x9gknd 5035 5 present present JJ cord-010119-t1x9gknd 5035 6 at at IN cord-010119-t1x9gknd 5035 7 all all DT cord-010119-t1x9gknd 5035 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5035 9 levels level NNS cord-010119-t1x9gknd 5035 10 . . . cord-010119-t1x9gknd 5036 1 There there EX cord-010119-t1x9gknd 5036 2 was be VBD cord-010119-t1x9gknd 5036 3 insufficient insufficient JJ cord-010119-t1x9gknd 5036 4 correlation correlation NN cord-010119-t1x9gknd 5036 5 with with IN cord-010119-t1x9gknd 5036 6 fs f NNS cord-010119-t1x9gknd 5036 7 HB HB NNP cord-010119-t1x9gknd 5036 8 and and CC cord-010119-t1x9gknd 5036 9 ven ven NNP cord-010119-t1x9gknd 5036 10 Fer Fer NNP cord-010119-t1x9gknd 5036 11 to to TO cord-010119-t1x9gknd 5036 12 support support VB cord-010119-t1x9gknd 5036 13 use use NN cord-010119-t1x9gknd 5036 14 of of IN cord-010119-t1x9gknd 5036 15 fs f NNS cord-010119-t1x9gknd 5036 16 or or CC cord-010119-t1x9gknd 5036 17 ven ven NNP cord-010119-t1x9gknd 5036 18 ZPP ZPP NNP cord-010119-t1x9gknd 5036 19 analysis analysis NN cord-010119-t1x9gknd 5036 20 as as IN cord-010119-t1x9gknd 5036 21 measurement measurement NN cord-010119-t1x9gknd 5036 22 of of IN cord-010119-t1x9gknd 5036 23 iron iron NN cord-010119-t1x9gknd 5036 24 stores store NNS cord-010119-t1x9gknd 5036 25 for for IN cord-010119-t1x9gknd 5036 26 blood blood NN cord-010119-t1x9gknd 5036 27 donors donor NNS cord-010119-t1x9gknd 5036 28 . . . cord-010119-t1x9gknd 5037 1 Symptoms symptom NNS cord-010119-t1x9gknd 5037 2 reported report VBN cord-010119-t1x9gknd 5037 3 by by IN cord-010119-t1x9gknd 5037 4 study study NN cord-010119-t1x9gknd 5037 5 participants participant NNS cord-010119-t1x9gknd 5037 6 were be VBD cord-010119-t1x9gknd 5037 7 not not RB cord-010119-t1x9gknd 5037 8 consistent consistent JJ cord-010119-t1x9gknd 5037 9 with with IN cord-010119-t1x9gknd 5037 10 laboratory laboratory NN cord-010119-t1x9gknd 5037 11 results result NNS cord-010119-t1x9gknd 5037 12 . . . cord-010119-t1x9gknd 5038 1 The the DT cord-010119-t1x9gknd 5038 2 minimum minimum JJ cord-010119-t1x9gknd 5038 3 male male NN cord-010119-t1x9gknd 5038 4 Hb Hb NNP cord-010119-t1x9gknd 5038 5 was be VBD cord-010119-t1x9gknd 5038 6 raised raise VBN cord-010119-t1x9gknd 5038 7 from from IN cord-010119-t1x9gknd 5039 1 12.5 12.5 CD cord-010119-t1x9gknd 5039 2 to to IN cord-010119-t1x9gknd 5039 3 13.0 13.0 CD cord-010119-t1x9gknd 5039 4 gm gm NNP cord-010119-t1x9gknd 5039 5 / / SYM cord-010119-t1x9gknd 5039 6 dL. dL. NNS cord-010119-t1x9gknd 5039 7 FDA FDA NNP cord-010119-t1x9gknd 5039 8 imposed impose VBD cord-010119-t1x9gknd 5039 9 specific specific JJ cord-010119-t1x9gknd 5039 10 VS VS NNP cord-010119-t1x9gknd 5039 11 ranges range VBZ cord-010119-t1x9gknd 5039 12 for for IN cord-010119-t1x9gknd 5039 13 acceptable acceptable JJ cord-010119-t1x9gknd 5039 14 pulse pulse NN cord-010119-t1x9gknd 5039 15 ( ( -LRB- cord-010119-t1x9gknd 5039 16 P p NN cord-010119-t1x9gknd 5039 17 ) ) -RRB- cord-010119-t1x9gknd 5039 18 and and CC cord-010119-t1x9gknd 5039 19 blood blood NN cord-010119-t1x9gknd 5039 20 pressure pressure NN cord-010119-t1x9gknd 5039 21 ( ( -LRB- cord-010119-t1x9gknd 5039 22 BP BP NNP cord-010119-t1x9gknd 5039 23 ) ) -RRB- cord-010119-t1x9gknd 5039 24 , , , cord-010119-t1x9gknd 5039 25 removing remove VBG cord-010119-t1x9gknd 5039 26 center center NN cord-010119-t1x9gknd 5039 27 - - HYPH cord-010119-t1x9gknd 5039 28 by by IN cord-010119-t1x9gknd 5039 29 - - HYPH cord-010119-t1x9gknd 5039 30 center center NN cord-010119-t1x9gknd 5039 31 discretion discretion NN cord-010119-t1x9gknd 5039 32 . . . cord-010119-t1x9gknd 5040 1 A a DT cord-010119-t1x9gknd 5040 2 survey survey NN cord-010119-t1x9gknd 5040 3 of of IN cord-010119-t1x9gknd 5040 4 members member NNS cord-010119-t1x9gknd 5040 5 of of IN cord-010119-t1x9gknd 5040 6 America America NNP cord-010119-t1x9gknd 5040 7 's 's POS cord-010119-t1x9gknd 5040 8 Blood Blood NNP cord-010119-t1x9gknd 5040 9 Centers Centers NNPS cord-010119-t1x9gknd 5040 10 ( ( -LRB- cord-010119-t1x9gknd 5040 11 ABC ABC NNP cord-010119-t1x9gknd 5040 12 ) ) -RRB- cord-010119-t1x9gknd 5040 13 was be VBD cord-010119-t1x9gknd 5040 14 performed perform VBN cord-010119-t1x9gknd 5040 15 to to TO cord-010119-t1x9gknd 5040 16 assess assess VB cord-010119-t1x9gknd 5040 17 the the DT cord-010119-t1x9gknd 5040 18 impact impact NN cord-010119-t1x9gknd 5040 19 on on IN cord-010119-t1x9gknd 5040 20 donor donor NN cord-010119-t1x9gknd 5040 21 deferrals deferral NNS cord-010119-t1x9gknd 5040 22 resulting result VBG cord-010119-t1x9gknd 5040 23 from from IN cord-010119-t1x9gknd 5040 24 these these DT cord-010119-t1x9gknd 5040 25 changes change NNS cord-010119-t1x9gknd 5040 26 . . . cord-010119-t1x9gknd 5041 1 Study Study NNP cord-010119-t1x9gknd 5041 2 Design Design NNP cord-010119-t1x9gknd 5041 3 / / SYM cord-010119-t1x9gknd 5041 4 Method method NN cord-010119-t1x9gknd 5041 5 : : : cord-010119-t1x9gknd 5042 1 Online online JJ cord-010119-t1x9gknd 5042 2 survey survey NN cord-010119-t1x9gknd 5042 3 software software NN cord-010119-t1x9gknd 5042 4 ( ( -LRB- cord-010119-t1x9gknd 5042 5 SurveyGizmo SurveyGizmo NNP cord-010119-t1x9gknd 5042 6 , , , cord-010119-t1x9gknd 5042 7 Boulder Boulder NNP cord-010119-t1x9gknd 5042 8 , , , cord-010119-t1x9gknd 5042 9 CO CO NNP cord-010119-t1x9gknd 5042 10 ) ) -RRB- cord-010119-t1x9gknd 5042 11 was be VBD cord-010119-t1x9gknd 5042 12 used use VBN cord-010119-t1x9gknd 5042 13 to to TO cord-010119-t1x9gknd 5042 14 solicit solicit VB cord-010119-t1x9gknd 5042 15 collections collection NNS cord-010119-t1x9gknd 5042 16 and and CC cord-010119-t1x9gknd 5042 17 deferral deferral NN cord-010119-t1x9gknd 5042 18 information information NN cord-010119-t1x9gknd 5042 19 from from IN cord-010119-t1x9gknd 5042 20 59 59 CD cord-010119-t1x9gknd 5042 21 blood blood NN cord-010119-t1x9gknd 5042 22 centers center NNS cord-010119-t1x9gknd 5042 23 over over IN cord-010119-t1x9gknd 5042 24 two two CD cord-010119-t1x9gknd 5042 25 intervals interval NNS cord-010119-t1x9gknd 5042 26 , , , cord-010119-t1x9gknd 5042 27 July July NNP cord-010119-t1x9gknd 5042 28 - - HYPH cord-010119-t1x9gknd 5042 29 Dec Dec NNP cord-010119-t1x9gknd 5042 30 . . . cord-010119-t1x9gknd 5042 31 2015 2015 CD cord-010119-t1x9gknd 5042 32 and and CC cord-010119-t1x9gknd 5042 33 July July NNP cord-010119-t1x9gknd 5042 34 - - HYPH cord-010119-t1x9gknd 5042 35 Dec Dec NNP cord-010119-t1x9gknd 5042 36 . . . cord-010119-t1x9gknd 5042 37 2016 2016 CD cord-010119-t1x9gknd 5042 38 ( ( -LRB- cord-010119-t1x9gknd 5042 39 i.e. i.e. FW cord-010119-t1x9gknd 5042 40 , , , cord-010119-t1x9gknd 5042 41 before before IN cord-010119-t1x9gknd 5042 42 and and CC cord-010119-t1x9gknd 5042 43 after after IN cord-010119-t1x9gknd 5042 44 the the DT cord-010119-t1x9gknd 5042 45 implementation implementation NN cord-010119-t1x9gknd 5042 46 deadline deadline NN cord-010119-t1x9gknd 5042 47 for for IN cord-010119-t1x9gknd 5042 48 the the DT cord-010119-t1x9gknd 5042 49 final final JJ cord-010119-t1x9gknd 5042 50 rule rule NN cord-010119-t1x9gknd 5042 51 respectively respectively RB cord-010119-t1x9gknd 5042 52 ) ) -RRB- cord-010119-t1x9gknd 5042 53 . . . cord-010119-t1x9gknd 5043 1 Information information NN cord-010119-t1x9gknd 5043 2 on on IN cord-010119-t1x9gknd 5043 3 deferral deferral NN cord-010119-t1x9gknd 5043 4 at at IN cord-010119-t1x9gknd 5043 5 presentations presentation NNS cord-010119-t1x9gknd 5043 6 for for IN cord-010119-t1x9gknd 5043 7 whole whole JJ cord-010119-t1x9gknd 5043 8 blood blood NN cord-010119-t1x9gknd 5043 9 ( ( -LRB- cord-010119-t1x9gknd 5043 10 WB WB NNP cord-010119-t1x9gknd 5043 11 ) ) -RRB- cord-010119-t1x9gknd 5043 12 donations donation NNS cord-010119-t1x9gknd 5043 13 and and CC cord-010119-t1x9gknd 5043 14 apheresis apheresis NN cord-010119-t1x9gknd 5043 15 platelet platelet NN cord-010119-t1x9gknd 5044 1 ( ( -LRB- cord-010119-t1x9gknd 5044 2 AP AP NNP cord-010119-t1x9gknd 5044 3 ) ) -RRB- cord-010119-t1x9gknd 5044 4 donations donation NNS cord-010119-t1x9gknd 5044 5 was be VBD cord-010119-t1x9gknd 5044 6 requested request VBN cord-010119-t1x9gknd 5044 7 for for IN cord-010119-t1x9gknd 5044 8 Hb Hb NNP cord-010119-t1x9gknd 5044 9 thresholds threshold NNS cord-010119-t1x9gknd 5044 10 and and CC cord-010119-t1x9gknd 5044 11 VS VS NNP cord-010119-t1x9gknd 5044 12 . . . cord-010119-t1x9gknd 5045 1 The the DT cord-010119-t1x9gknd 5045 2 information information NN cord-010119-t1x9gknd 5045 3 was be VBD cord-010119-t1x9gknd 5045 4 stratified stratify VBN cord-010119-t1x9gknd 5045 5 by by IN cord-010119-t1x9gknd 5045 6 gender gender NN cord-010119-t1x9gknd 5045 7 ( ( -LRB- cord-010119-t1x9gknd 5045 8 male5 male5 NNP cord-010119-t1x9gknd 5045 9 M M NNP cord-010119-t1x9gknd 5045 10 , , , cord-010119-t1x9gknd 5045 11 female5F female5F NNP cord-010119-t1x9gknd 5045 12 ) ) -RRB- cord-010119-t1x9gknd 5045 13 , , , cord-010119-t1x9gknd 5045 14 and and CC cord-010119-t1x9gknd 5045 15 ABO ABO NNP cord-010119-t1x9gknd 5045 16 type type NN cord-010119-t1x9gknd 5045 17 . . . cord-010119-t1x9gknd 5046 1 Statistical statistical JJ cord-010119-t1x9gknd 5046 2 analysis analysis NN cord-010119-t1x9gknd 5046 3 included include VBD cord-010119-t1x9gknd 5046 4 t t NN cord-010119-t1x9gknd 5046 5 - - HYPH cord-010119-t1x9gknd 5046 6 tests test NNS cord-010119-t1x9gknd 5046 7 for for IN cord-010119-t1x9gknd 5046 8 numerical numerical JJ cord-010119-t1x9gknd 5046 9 and and CC cord-010119-t1x9gknd 5046 10 chi chi JJ cord-010119-t1x9gknd 5046 11 - - HYPH cord-010119-t1x9gknd 5046 12 square square JJ cord-010119-t1x9gknd 5046 13 for for IN cord-010119-t1x9gknd 5046 14 categorical categorical JJ cord-010119-t1x9gknd 5046 15 data datum NNS cord-010119-t1x9gknd 5046 16 ( ( -LRB- cord-010119-t1x9gknd 5046 17 Minitab Minitab NNP cord-010119-t1x9gknd 5046 18 17.0 17.0 CD cord-010119-t1x9gknd 5046 19 , , , cord-010119-t1x9gknd 5046 20 Chicago Chicago NNP cord-010119-t1x9gknd 5046 21 IL IL NNP cord-010119-t1x9gknd 5046 22 ) ) -RRB- cord-010119-t1x9gknd 5046 23 . . . cord-010119-t1x9gknd 5047 1 P p NN cord-010119-t1x9gknd 5047 2 < < XX cord-010119-t1x9gknd 5047 3 .05 .05 NNP cord-010119-t1x9gknd 5047 4 was be VBD cord-010119-t1x9gknd 5047 5 considered consider VBN cord-010119-t1x9gknd 5047 6 significant significant JJ cord-010119-t1x9gknd 5047 7 . . . cord-010119-t1x9gknd 5048 1 Results/ Results/ . cord-010119-t1x9gknd 5049 1 Findings finding NNS cord-010119-t1x9gknd 5049 2 : : : cord-010119-t1x9gknd 5050 1 Data datum NNS cord-010119-t1x9gknd 5050 2 were be VBD cord-010119-t1x9gknd 5050 3 provided provide VBN cord-010119-t1x9gknd 5050 4 by by IN cord-010119-t1x9gknd 5050 5 40 40 CD cord-010119-t1x9gknd 5050 6 of of IN cord-010119-t1x9gknd 5050 7 59 59 CD cord-010119-t1x9gknd 5050 8 centers center NNS cord-010119-t1x9gknd 5050 9 invited invite VBN cord-010119-t1x9gknd 5050 10 , , , cord-010119-t1x9gknd 5050 11 representing represent VBG cord-010119-t1x9gknd 5050 12 2,420,886 2,420,886 CD cord-010119-t1x9gknd 5050 13 and and CC cord-010119-t1x9gknd 5050 14 2,945,802 2,945,802 CD cord-010119-t1x9gknd 5050 15 WB WB NNP cord-010119-t1x9gknd 5050 16 donations donation NNS cord-010119-t1x9gknd 5050 17 and and CC cord-010119-t1x9gknd 5050 18 272,094 272,094 CD cord-010119-t1x9gknd 5050 19 and and CC cord-010119-t1x9gknd 5050 20 319,161 319,161 CD cord-010119-t1x9gknd 5050 21 AP AP NNP cord-010119-t1x9gknd 5050 22 donations donation NNS cord-010119-t1x9gknd 5050 23 in in IN cord-010119-t1x9gknd 5050 24 aggregate aggregate NN cord-010119-t1x9gknd 5050 25 during during IN cord-010119-t1x9gknd 5050 26 the the DT cord-010119-t1x9gknd 5050 27 two two CD cord-010119-t1x9gknd 5050 28 intervals interval NNS cord-010119-t1x9gknd 5050 29 respectively respectively RB cord-010119-t1x9gknd 5050 30 . . . cord-010119-t1x9gknd 5051 1 Gender gender NN cord-010119-t1x9gknd 5051 2 and and CC cord-010119-t1x9gknd 5051 3 ABO ABO NNP cord-010119-t1x9gknd 5051 4 distributions distribution NNS cord-010119-t1x9gknd 5051 5 appeared appear VBD cord-010119-t1x9gknd 5051 6 representative representative NN cord-010119-t1x9gknd 5051 7 of of IN cord-010119-t1x9gknd 5051 8 the the DT cord-010119-t1x9gknd 5051 9 US US NNP cord-010119-t1x9gknd 5051 10 donor donor NN cord-010119-t1x9gknd 5051 11 base base NN cord-010119-t1x9gknd 5051 12 . . . cord-010119-t1x9gknd 5052 1 Among among IN cord-010119-t1x9gknd 5052 2 M M NNP cord-010119-t1x9gknd 5052 3 WB WB NNP cord-010119-t1x9gknd 5052 4 donors donor NNS cord-010119-t1x9gknd 5052 5 the the DT cord-010119-t1x9gknd 5052 6 rate rate NN cord-010119-t1x9gknd 5052 7 of of IN cord-010119-t1x9gknd 5052 8 deferral deferral NN cord-010119-t1x9gknd 5052 9 rose rise VBD cord-010119-t1x9gknd 5052 10 from from IN cord-010119-t1x9gknd 5052 11 1.5 1.5 CD cord-010119-t1x9gknd 5052 12 % % NN cord-010119-t1x9gknd 5052 13 to to IN cord-010119-t1x9gknd 5052 14 2.9 2.9 CD cord-010119-t1x9gknd 5052 15 % % NN cord-010119-t1x9gknd 5052 16 in in IN cord-010119-t1x9gknd 5052 17 the the DT cord-010119-t1x9gknd 5052 18 two two CD cord-010119-t1x9gknd 5052 19 intervals interval NNS cord-010119-t1x9gknd 5052 20 among among IN cord-010119-t1x9gknd 5052 21 aggregated aggregated JJ cord-010119-t1x9gknd 5052 22 donation donation NN cord-010119-t1x9gknd 5052 23 attempts attempt NNS cord-010119-t1x9gknd 5052 24 ( ( -LRB- cord-010119-t1x9gknd 5052 25 p<.001 p<.001 NNP cord-010119-t1x9gknd 5052 26 ) ) -RRB- cord-010119-t1x9gknd 5052 27 , , , cord-010119-t1x9gknd 5052 28 and and CC cord-010119-t1x9gknd 5052 29 for for IN cord-010119-t1x9gknd 5052 30 M M NNP cord-010119-t1x9gknd 5052 31 AP AP NNP cord-010119-t1x9gknd 5052 32 from from IN cord-010119-t1x9gknd 5052 33 1.8 1.8 CD cord-010119-t1x9gknd 5052 34 to to IN cord-010119-t1x9gknd 5052 35 3.5 3.5 CD cord-010119-t1x9gknd 5052 36 % % NN cord-010119-t1x9gknd 5052 37 ( ( -LRB- cord-010119-t1x9gknd 5052 38 p<.001 p<.001 NNP cord-010119-t1x9gknd 5052 39 ) ) -RRB- cord-010119-t1x9gknd 5052 40 . . . cord-010119-t1x9gknd 5053 1 The the DT cord-010119-t1x9gknd 5053 2 mean mean NN cord-010119-t1x9gknd 5053 3 " " '' cord-010119-t1x9gknd 5053 4 by by IN cord-010119-t1x9gknd 5053 5 center center NN cord-010119-t1x9gknd 5053 6 " " '' cord-010119-t1x9gknd 5053 7 deferral deferral NN cord-010119-t1x9gknd 5053 8 rates rate NNS cord-010119-t1x9gknd 5053 9 ( ( -LRB- cord-010119-t1x9gknd 5053 10 table table NN cord-010119-t1x9gknd 5053 11 ) ) -RRB- cord-010119-t1x9gknd 5053 12 were be VBD cord-010119-t1x9gknd 5053 13 similar similar JJ cord-010119-t1x9gknd 5053 14 to to IN cord-010119-t1x9gknd 5053 15 that that DT cord-010119-t1x9gknd 5053 16 and and CC cord-010119-t1x9gknd 5053 17 significant significant JJ cord-010119-t1x9gknd 5053 18 ( ( -LRB- cord-010119-t1x9gknd 5053 19 p<.001 p<.001 JJ cord-010119-t1x9gknd 5053 20 ) ) -RRB- cord-010119-t1x9gknd 5053 21 . . . cord-010119-t1x9gknd 5054 1 Mean mean JJ cord-010119-t1x9gknd 5054 2 by by IN cord-010119-t1x9gknd 5054 3 center center NN cord-010119-t1x9gknd 5054 4 Hb Hb NNP cord-010119-t1x9gknd 5054 5 deferral deferral NN cord-010119-t1x9gknd 5054 6 rates rate NNS cord-010119-t1x9gknd 5054 7 among among IN cord-010119-t1x9gknd 5054 8 F F NNP cord-010119-t1x9gknd 5054 9 donations donation NNS cord-010119-t1x9gknd 5054 10 during during IN cord-010119-t1x9gknd 5054 11 the the DT cord-010119-t1x9gknd 5054 12 two two CD cord-010119-t1x9gknd 5054 13 intervals interval NNS cord-010119-t1x9gknd 5054 14 were be VBD cord-010119-t1x9gknd 5054 15 11.6 11.6 CD cord-010119-t1x9gknd 5054 16 and and CC cord-010119-t1x9gknd 5054 17 11.9 11.9 CD cord-010119-t1x9gknd 5054 18 % % NN cord-010119-t1x9gknd 5054 19 ( ( -LRB- cord-010119-t1x9gknd 5054 20 p50.241 p50.241 NNP cord-010119-t1x9gknd 5054 21 ) ) -RRB- cord-010119-t1x9gknd 5054 22 for for IN cord-010119-t1x9gknd 5054 23 WB WB NNP cord-010119-t1x9gknd 5054 24 , , , cord-010119-t1x9gknd 5054 25 11.8 11.8 CD cord-010119-t1x9gknd 5054 26 and and CC cord-010119-t1x9gknd 5054 27 13.0 13.0 CD cord-010119-t1x9gknd 5054 28 % % NN cord-010119-t1x9gknd 5054 29 ( ( -LRB- cord-010119-t1x9gknd 5054 30 p5.041 p5.041 NNP cord-010119-t1x9gknd 5054 31 ) ) -RRB- cord-010119-t1x9gknd 5054 32 for for IN cord-010119-t1x9gknd 5054 33 AP AP NNP cord-010119-t1x9gknd 5054 34 , , , cord-010119-t1x9gknd 5054 35 respectively respectively RB cord-010119-t1x9gknd 5054 36 , , , cord-010119-t1x9gknd 5054 37 absent absent VBP cord-010119-t1x9gknd 5054 38 any any DT cord-010119-t1x9gknd 5054 39 change change NN cord-010119-t1x9gknd 5054 40 in in IN cord-010119-t1x9gknd 5054 41 their -PRON- PRP$ cord-010119-t1x9gknd 5054 42 acceptable acceptable JJ cord-010119-t1x9gknd 5054 43 Hb Hb NNP cord-010119-t1x9gknd 5054 44 thresholds threshold NNS cord-010119-t1x9gknd 5054 45 . . . cord-010119-t1x9gknd 5055 1 Data datum NNS cord-010119-t1x9gknd 5055 2 on on IN cord-010119-t1x9gknd 5055 3 VS VS NNP cord-010119-t1x9gknd 5055 4 deferrals deferral NNS cord-010119-t1x9gknd 5055 5 were be VBD cord-010119-t1x9gknd 5055 6 much much RB cord-010119-t1x9gknd 5055 7 sparser sparse JJR cord-010119-t1x9gknd 5055 8 . . . cord-010119-t1x9gknd 5056 1 For for IN cord-010119-t1x9gknd 5056 2 P p NN cord-010119-t1x9gknd 5056 3 deferrals deferral NNS cord-010119-t1x9gknd 5056 4 , , , cord-010119-t1x9gknd 5056 5 only only RB cord-010119-t1x9gknd 5056 6 12 12 CD cord-010119-t1x9gknd 5056 7 centers center NNS cord-010119-t1x9gknd 5056 8 could could MD cord-010119-t1x9gknd 5056 9 provide provide VB cord-010119-t1x9gknd 5056 10 specific specific JJ cord-010119-t1x9gknd 5056 11 high high JJ cord-010119-t1x9gknd 5056 12 vs. vs. FW cord-010119-t1x9gknd 5056 13 low low JJ cord-010119-t1x9gknd 5056 14 vs. vs. FW cord-010119-t1x9gknd 5056 15 irregular irregular JJ cord-010119-t1x9gknd 5056 16 pulse pulse NN cord-010119-t1x9gknd 5056 17 deferrals deferral NNS cord-010119-t1x9gknd 5056 18 ; ; : cord-010119-t1x9gknd 5056 19 27 27 CD cord-010119-t1x9gknd 5056 20 provided provide VBD cord-010119-t1x9gknd 5056 21 only only RB cord-010119-t1x9gknd 5056 22 a a DT cord-010119-t1x9gknd 5056 23 summary summary NN cord-010119-t1x9gknd 5056 24 ( ( -LRB- cord-010119-t1x9gknd 5056 25 i.e i.e FW cord-010119-t1x9gknd 5056 26 total total JJ cord-010119-t1x9gknd 5056 27 pulse pulse NN cord-010119-t1x9gknd 5056 28 deferrals deferral NNS cord-010119-t1x9gknd 5056 29 ) ) -RRB- cord-010119-t1x9gknd 5056 30 , , , cord-010119-t1x9gknd 5056 31 and and CC cord-010119-t1x9gknd 5056 32 1 1 CD cord-010119-t1x9gknd 5056 33 could could MD cord-010119-t1x9gknd 5056 34 provide provide VB cord-010119-t1x9gknd 5056 35 none none NN cord-010119-t1x9gknd 5056 36 . . . cord-010119-t1x9gknd 5057 1 For for IN cord-010119-t1x9gknd 5057 2 BP BP NNP cord-010119-t1x9gknd 5057 3 , , , cord-010119-t1x9gknd 5057 4 8 8 CD cord-010119-t1x9gknd 5057 5 provided provide VBN cord-010119-t1x9gknd 5057 6 detail detail NN cord-010119-t1x9gknd 5057 7 ( ( -LRB- cord-010119-t1x9gknd 5057 8 high high JJ cord-010119-t1x9gknd 5057 9 vs. vs. IN cord-010119-t1x9gknd 5057 10 low low JJ cord-010119-t1x9gknd 5057 11 ) ) -RRB- cord-010119-t1x9gknd 5057 12 , , , cord-010119-t1x9gknd 5057 13 28 28 CD cord-010119-t1x9gknd 5057 14 summary summary NN cord-010119-t1x9gknd 5057 15 and and CC cord-010119-t1x9gknd 5057 16 4 4 CD cord-010119-t1x9gknd 5057 17 none none NN cord-010119-t1x9gknd 5057 18 . . . cord-010119-t1x9gknd 5058 1 P p NN cord-010119-t1x9gknd 5058 2 deferrals deferral NNS cord-010119-t1x9gknd 5058 3 increased increase VBD cord-010119-t1x9gknd 5058 4 in in IN cord-010119-t1x9gknd 5058 5 the the DT cord-010119-t1x9gknd 5058 6 successive successive JJ cord-010119-t1x9gknd 5058 7 intervals interval NNS cord-010119-t1x9gknd 5058 8 among among IN cord-010119-t1x9gknd 5058 9 F F NNP cord-010119-t1x9gknd 5058 10 WB WB NNP cord-010119-t1x9gknd 5058 11 donors donor NNS cord-010119-t1x9gknd 5058 12 from from IN cord-010119-t1x9gknd 5058 13 a a DT cord-010119-t1x9gknd 5058 14 center center NN cord-010119-t1x9gknd 5058 15 mean mean NN cord-010119-t1x9gknd 5058 16 of of IN cord-010119-t1x9gknd 5058 17 0.57 0.57 CD cord-010119-t1x9gknd 5058 18 to to TO cord-010119-t1x9gknd 5058 19 1.49 1.49 CD cord-010119-t1x9gknd 5058 20 % % NN cord-010119-t1x9gknd 5058 21 ( ( -LRB- cord-010119-t1x9gknd 5058 22 p5.018 p5.018 NN cord-010119-t1x9gknd 5058 23 ) ) -RRB- cord-010119-t1x9gknd 5058 24 and and CC cord-010119-t1x9gknd 5058 25 for for IN cord-010119-t1x9gknd 5058 26 M M NNP cord-010119-t1x9gknd 5058 27 WB WB NNP cord-010119-t1x9gknd 5058 28 donors donor NNS cord-010119-t1x9gknd 5058 29 from from IN cord-010119-t1x9gknd 5058 30 0.78 0.78 CD cord-010119-t1x9gknd 5058 31 to to IN cord-010119-t1x9gknd 5058 32 1.16 1.16 CD cord-010119-t1x9gknd 5058 33 % % NN cord-010119-t1x9gknd 5058 34 ( ( -LRB- cord-010119-t1x9gknd 5058 35 p5.006 p5.006 NNP cord-010119-t1x9gknd 5058 36 ) ) -RRB- cord-010119-t1x9gknd 5058 37 . . . cord-010119-t1x9gknd 5059 1 Where where WRB cord-010119-t1x9gknd 5059 2 details detail NNS cord-010119-t1x9gknd 5059 3 were be VBD cord-010119-t1x9gknd 5059 4 available available JJ cord-010119-t1x9gknd 5059 5 , , , cord-010119-t1x9gknd 5059 6 high high JJ cord-010119-t1x9gknd 5059 7 and and CC cord-010119-t1x9gknd 5059 8 irregular irregular JJ cord-010119-t1x9gknd 5059 9 pulses pulse NNS cord-010119-t1x9gknd 5059 10 were be VBD cord-010119-t1x9gknd 5059 11 responsible responsible JJ cord-010119-t1x9gknd 5059 12 for for IN cord-010119-t1x9gknd 5059 13 most most JJS cord-010119-t1x9gknd 5059 14 of of IN cord-010119-t1x9gknd 5059 15 the the DT cord-010119-t1x9gknd 5059 16 changes change NNS cord-010119-t1x9gknd 5059 17 for for IN cord-010119-t1x9gknd 5059 18 both both DT cord-010119-t1x9gknd 5059 19 genders gender NNS cord-010119-t1x9gknd 5059 20 . . . cord-010119-t1x9gknd 5060 1 BP BP NNP cord-010119-t1x9gknd 5060 2 deferrals deferral NNS cord-010119-t1x9gknd 5060 3 were be VBD cord-010119-t1x9gknd 5060 4 not not RB cord-010119-t1x9gknd 5060 5 significantly significantly RB cord-010119-t1x9gknd 5060 6 increased increase VBN cord-010119-t1x9gknd 5060 7 among among IN cord-010119-t1x9gknd 5060 8 WB WB NNP cord-010119-t1x9gknd 5060 9 donors donor NNS cord-010119-t1x9gknd 5060 10 , , , cord-010119-t1x9gknd 5060 11 regardless regardless RB cord-010119-t1x9gknd 5060 12 of of IN cord-010119-t1x9gknd 5060 13 gender gender NN cord-010119-t1x9gknd 5060 14 . . . cord-010119-t1x9gknd 5061 1 The the DT cord-010119-t1x9gknd 5061 2 data data NN cord-010119-t1x9gknd 5061 3 sets set NNS cord-010119-t1x9gknd 5061 4 and and CC cord-010119-t1x9gknd 5061 5 deferral deferral NN cord-010119-t1x9gknd 5061 6 rates rate NNS cord-010119-t1x9gknd 5062 1 re re IN cord-010119-t1x9gknd 5062 2 : : : cord-010119-t1x9gknd 5062 3 VS VS NNP cord-010119-t1x9gknd 5062 4 in in IN cord-010119-t1x9gknd 5062 5 AP AP NNP cord-010119-t1x9gknd 5062 6 donors donor NNS cord-010119-t1x9gknd 5062 7 were be VBD cord-010119-t1x9gknd 5062 8 quite quite RB cord-010119-t1x9gknd 5062 9 small small JJ cord-010119-t1x9gknd 5062 10 , , , cord-010119-t1x9gknd 5062 11 possibly possibly RB cord-010119-t1x9gknd 5062 12 reflecting reflect VBG cord-010119-t1x9gknd 5062 13 culling culling NN cord-010119-t1x9gknd 5062 14 during during IN cord-010119-t1x9gknd 5062 15 their -PRON- PRP$ cord-010119-t1x9gknd 5062 16 prior prior JJ cord-010119-t1x9gknd 5062 17 donation donation NN cord-010119-t1x9gknd 5062 18 experience experience NN cord-010119-t1x9gknd 5062 19 . . . cord-010119-t1x9gknd 5063 1 Conclusion conclusion NN cord-010119-t1x9gknd 5063 2 : : : cord-010119-t1x9gknd 5063 3 Substantial substantial JJ cord-010119-t1x9gknd 5063 4 additional additional JJ cord-010119-t1x9gknd 5063 5 donor donor NN cord-010119-t1x9gknd 5063 6 deferrals deferral NNS cord-010119-t1x9gknd 5063 7 attended attend VBD cord-010119-t1x9gknd 5063 8 the the DT cord-010119-t1x9gknd 5063 9 increased increase VBN cord-010119-t1x9gknd 5063 10 Hb Hb NNP cord-010119-t1x9gknd 5063 11 thresholds threshold NNS cord-010119-t1x9gknd 5063 12 for for IN cord-010119-t1x9gknd 5063 13 M M NNP cord-010119-t1x9gknd 5063 14 in in IN cord-010119-t1x9gknd 5063 15 the the DT cord-010119-t1x9gknd 5063 16 final final JJ cord-010119-t1x9gknd 5063 17 rule rule NN cord-010119-t1x9gknd 5063 18 , , , cord-010119-t1x9gknd 5063 19 for for IN cord-010119-t1x9gknd 5063 20 both both DT cord-010119-t1x9gknd 5063 21 WB WB NNP cord-010119-t1x9gknd 5063 22 and and CC cord-010119-t1x9gknd 5063 23 AP AP NNP cord-010119-t1x9gknd 5063 24 . . . cord-010119-t1x9gknd 5064 1 Changes change NNS cord-010119-t1x9gknd 5064 2 were be VBD cord-010119-t1x9gknd 5064 3 more more RBR cord-010119-t1x9gknd 5064 4 modest modest JJ cord-010119-t1x9gknd 5064 5 among among IN cord-010119-t1x9gknd 5064 6 female female JJ cord-010119-t1x9gknd 5064 7 donors donor NNS cord-010119-t1x9gknd 5064 8 , , , cord-010119-t1x9gknd 5064 9 consistent consistent JJ cord-010119-t1x9gknd 5064 10 with with IN cord-010119-t1x9gknd 5064 11 the the DT cord-010119-t1x9gknd 5064 12 absence absence NN cord-010119-t1x9gknd 5064 13 of of IN cord-010119-t1x9gknd 5064 14 changes change NNS cord-010119-t1x9gknd 5064 15 in in IN cord-010119-t1x9gknd 5064 16 allowable allowable JJ cord-010119-t1x9gknd 5064 17 Hb Hb NNP cord-010119-t1x9gknd 5064 18 levels level NNS cord-010119-t1x9gknd 5064 19 . . . cord-010119-t1x9gknd 5065 1 Modest modest JJ cord-010119-t1x9gknd 5065 2 but but CC cord-010119-t1x9gknd 5065 3 significant significant JJ cord-010119-t1x9gknd 5065 4 changes change NNS cord-010119-t1x9gknd 5065 5 attended attend VBD cord-010119-t1x9gknd 5065 6 more more RBR cord-010119-t1x9gknd 5065 7 stringent stringent JJ cord-010119-t1x9gknd 5065 8 requirements requirement NNS cord-010119-t1x9gknd 5065 9 for for IN cord-010119-t1x9gknd 5065 10 VS VS NNP cord-010119-t1x9gknd 5065 11 , , , cord-010119-t1x9gknd 5065 12 though though IN cord-010119-t1x9gknd 5065 13 data datum NNS cord-010119-t1x9gknd 5065 14 limitations limitation NNS cord-010119-t1x9gknd 5065 15 restrict restrict VBP cord-010119-t1x9gknd 5065 16 this this DT cord-010119-t1x9gknd 5065 17 aspect aspect NN cord-010119-t1x9gknd 5065 18 of of IN cord-010119-t1x9gknd 5065 19 the the DT cord-010119-t1x9gknd 5065 20 analysis analysis NN cord-010119-t1x9gknd 5065 21 . . . cord-010119-t1x9gknd 5066 1 Background Background NNP cord-010119-t1x9gknd 5066 2 / / SYM cord-010119-t1x9gknd 5066 3 Case Case NNP cord-010119-t1x9gknd 5066 4 Studies Studies NNPS cord-010119-t1x9gknd 5066 5 : : : cord-010119-t1x9gknd 5066 6 Diabetes diabetes NN cord-010119-t1x9gknd 5066 7 mellitus mellitus NN cord-010119-t1x9gknd 5066 8 is be VBZ cord-010119-t1x9gknd 5066 9 reaching reach VBG cord-010119-t1x9gknd 5066 10 potentially potentially RB cord-010119-t1x9gknd 5066 11 epidemic epidemic JJ cord-010119-t1x9gknd 5066 12 proportions proportion NNS cord-010119-t1x9gknd 5066 13 in in IN cord-010119-t1x9gknd 5066 14 India India NNP cord-010119-t1x9gknd 5066 15 . . . cord-010119-t1x9gknd 5067 1 Given give VBN cord-010119-t1x9gknd 5067 2 the the DT cord-010119-t1x9gknd 5067 3 disease disease NN cord-010119-t1x9gknd 5067 4 is be VBZ cord-010119-t1x9gknd 5067 5 now now RB cord-010119-t1x9gknd 5067 6 highly highly RB cord-010119-t1x9gknd 5067 7 visible visible JJ cord-010119-t1x9gknd 5067 8 across across IN cord-010119-t1x9gknd 5067 9 all all DT cord-010119-t1x9gknd 5067 10 sections section NNS cord-010119-t1x9gknd 5067 11 of of IN cord-010119-t1x9gknd 5067 12 society society NN cord-010119-t1x9gknd 5067 13 within within IN cord-010119-t1x9gknd 5067 14 India India NNP cord-010119-t1x9gknd 5067 15 , , , cord-010119-t1x9gknd 5067 16 there there EX cord-010119-t1x9gknd 5067 17 is be VBZ cord-010119-t1x9gknd 5067 18 now now RB cord-010119-t1x9gknd 5067 19 the the DT cord-010119-t1x9gknd 5067 20 demand demand NN cord-010119-t1x9gknd 5067 21 for for IN cord-010119-t1x9gknd 5067 22 screening screening NN cord-010119-t1x9gknd 5067 23 of of IN cord-010119-t1x9gknd 5067 24 diabetes diabetes NN cord-010119-t1x9gknd 5067 25 and and CC cord-010119-t1x9gknd 5067 26 urgent urgent JJ cord-010119-t1x9gknd 5067 27 research research NN cord-010119-t1x9gknd 5067 28 and and CC cord-010119-t1x9gknd 5067 29 intervention intervention NN cord-010119-t1x9gknd 5067 30 -at -at VBP cord-010119-t1x9gknd 5067 31 regional regional JJ cord-010119-t1x9gknd 5067 32 and and CC cord-010119-t1x9gknd 5067 33 national national JJ cord-010119-t1x9gknd 5067 34 levels level NNS cord-010119-t1x9gknd 5067 35 -to -to : cord-010119-t1x9gknd 5067 36 try try VBP cord-010119-t1x9gknd 5067 37 to to TO cord-010119-t1x9gknd 5067 38 mitigate mitigate VB cord-010119-t1x9gknd 5067 39 the the DT cord-010119-t1x9gknd 5067 40 potentially potentially RB cord-010119-t1x9gknd 5067 41 catastrophic catastrophic JJ cord-010119-t1x9gknd 5067 42 increase increase NN cord-010119-t1x9gknd 5067 43 in in IN cord-010119-t1x9gknd 5067 44 diabetes diabetes NN cord-010119-t1x9gknd 5067 45 that that WDT cord-010119-t1x9gknd 5067 46 is be VBZ cord-010119-t1x9gknd 5067 47 predicted predict VBN cord-010119-t1x9gknd 5067 48 for for IN cord-010119-t1x9gknd 5067 49 the the DT cord-010119-t1x9gknd 5067 50 upcoming upcoming JJ cord-010119-t1x9gknd 5067 51 years year NNS cord-010119-t1x9gknd 5067 52 . . . cord-010119-t1x9gknd 5068 1 Due due IN cord-010119-t1x9gknd 5068 2 to to IN cord-010119-t1x9gknd 5068 3 its -PRON- PRP$ cord-010119-t1x9gknd 5068 4 ease ease NN cord-010119-t1x9gknd 5068 5 of of IN cord-010119-t1x9gknd 5068 6 use use NN cord-010119-t1x9gknd 5068 7 , , , cord-010119-t1x9gknd 5068 8 several several JJ cord-010119-t1x9gknd 5068 9 studies study NNS cord-010119-t1x9gknd 5068 10 have have VBP cord-010119-t1x9gknd 5068 11 found find VBN cord-010119-t1x9gknd 5068 12 that that IN cord-010119-t1x9gknd 5068 13 HbA1c HbA1c NNP cord-010119-t1x9gknd 5068 14 testing testing NN cord-010119-t1x9gknd 5068 15 can can MD cord-010119-t1x9gknd 5068 16 identify identify VB cord-010119-t1x9gknd 5068 17 patients patient NNS cord-010119-t1x9gknd 5068 18 in in IN cord-010119-t1x9gknd 5068 19 the the DT cord-010119-t1x9gknd 5068 20 community community NN cord-010119-t1x9gknd 5068 21 who who WP cord-010119-t1x9gknd 5068 22 might may MD cord-010119-t1x9gknd 5068 23 otherwise otherwise RB cord-010119-t1x9gknd 5068 24 go go VB cord-010119-t1x9gknd 5068 25 undiagnosed undiagnosed JJ cord-010119-t1x9gknd 5068 26 . . . cord-010119-t1x9gknd 5069 1 We -PRON- PRP cord-010119-t1x9gknd 5069 2 took take VBD cord-010119-t1x9gknd 5069 3 an an DT cord-010119-t1x9gknd 5069 4 initiative initiative NN cord-010119-t1x9gknd 5069 5 to to TO cord-010119-t1x9gknd 5069 6 find find VB cord-010119-t1x9gknd 5069 7 out out RP cord-010119-t1x9gknd 5069 8 the the DT cord-010119-t1x9gknd 5069 9 incidence incidence NN cord-010119-t1x9gknd 5069 10 of of IN cord-010119-t1x9gknd 5069 11 diabetes diabetes NN cord-010119-t1x9gknd 5069 12 by by IN cord-010119-t1x9gknd 5069 13 random random JJ cord-010119-t1x9gknd 5069 14 blood blood NN cord-010119-t1x9gknd 5069 15 sugar sugar NN cord-010119-t1x9gknd 5069 16 ( ( -LRB- cord-010119-t1x9gknd 5069 17 RBS RBS NNP cord-010119-t1x9gknd 5069 18 ) ) -RRB- cord-010119-t1x9gknd 5069 19 measurement measurement NN cord-010119-t1x9gknd 5069 20 among among IN cord-010119-t1x9gknd 5069 21 Indian indian JJ cord-010119-t1x9gknd 5069 22 blood blood NN cord-010119-t1x9gknd 5069 23 donors donor NNS cord-010119-t1x9gknd 5069 24 and and CC cord-010119-t1x9gknd 5069 25 measure measure VB cord-010119-t1x9gknd 5069 26 the the DT cord-010119-t1x9gknd 5069 27 HbA1c HbA1c NNP cord-010119-t1x9gknd 5069 28 levels level NNS cord-010119-t1x9gknd 5069 29 among among IN cord-010119-t1x9gknd 5069 30 those those DT cord-010119-t1x9gknd 5069 31 with with IN cord-010119-t1x9gknd 5069 32 RBS RBS NNP cord-010119-t1x9gknd 5069 33 > > XX cord-010119-t1x9gknd 5070 1 180 180 CD cord-010119-t1x9gknd 5070 2 mg mg NNP cord-010119-t1x9gknd 5070 3 / / SYM cord-010119-t1x9gknd 5070 4 dL dL NNP cord-010119-t1x9gknd 5070 5 Study Study NNP cord-010119-t1x9gknd 5070 6 Design Design NNP cord-010119-t1x9gknd 5070 7 / / SYM cord-010119-t1x9gknd 5070 8 Methods method NNS cord-010119-t1x9gknd 5070 9 : : : cord-010119-t1x9gknd 5070 10 A a DT cord-010119-t1x9gknd 5070 11 prospective prospective JJ cord-010119-t1x9gknd 5070 12 study study NN cord-010119-t1x9gknd 5070 13 was be VBD cord-010119-t1x9gknd 5070 14 done do VBN cord-010119-t1x9gknd 5070 15 at at IN cord-010119-t1x9gknd 5070 16 department department NN cord-010119-t1x9gknd 5070 17 of of IN cord-010119-t1x9gknd 5070 18 Transfusion Transfusion NNP cord-010119-t1x9gknd 5070 19 Medicine Medicine NNP cord-010119-t1x9gknd 5070 20 and and CC cord-010119-t1x9gknd 5070 21 department department NN cord-010119-t1x9gknd 5070 22 of of IN cord-010119-t1x9gknd 5070 23 Biochemistry Biochemistry NNP cord-010119-t1x9gknd 5070 24 from from IN cord-010119-t1x9gknd 5070 25 1 1 CD cord-010119-t1x9gknd 5070 26 st st NNP cord-010119-t1x9gknd 5070 27 March March NNP cord-010119-t1x9gknd 5070 28 2017 2017 CD cord-010119-t1x9gknd 5070 29 to to IN cord-010119-t1x9gknd 5070 30 31 31 CD cord-010119-t1x9gknd 5070 31 st st NNP cord-010119-t1x9gknd 5070 32 March March NNP cord-010119-t1x9gknd 5070 33 2017 2017 CD cord-010119-t1x9gknd 5070 34 . . . cord-010119-t1x9gknd 5071 1 Total total NN cord-010119-t1x9gknd 5071 2 of of IN cord-010119-t1x9gknd 5071 3 1,861 1,861 CD cord-010119-t1x9gknd 5071 4 blood blood NN cord-010119-t1x9gknd 5071 5 donors donor NNS cord-010119-t1x9gknd 5071 6 were be VBD cord-010119-t1x9gknd 5071 7 tested test VBN cord-010119-t1x9gknd 5071 8 for for IN cord-010119-t1x9gknd 5071 9 RBS RBS NNP cord-010119-t1x9gknd 5071 10 . . . cord-010119-t1x9gknd 5072 1 Those those DT cord-010119-t1x9gknd 5072 2 with with IN cord-010119-t1x9gknd 5072 3 RBS RBS NNP cord-010119-t1x9gknd 5072 4 > > XX cord-010119-t1x9gknd 5072 5 180 180 CD cord-010119-t1x9gknd 5072 6 mg mg NNP cord-010119-t1x9gknd 5072 7 / / SYM cord-010119-t1x9gknd 5072 8 dl dl NNP cord-010119-t1x9gknd 5072 9 were be VBD cord-010119-t1x9gknd 5072 10 further further RB cord-010119-t1x9gknd 5072 11 tested test VBN cord-010119-t1x9gknd 5072 12 for for IN cord-010119-t1x9gknd 5072 13 HbA1c hba1c NN cord-010119-t1x9gknd 5072 14 by by IN cord-010119-t1x9gknd 5072 15 gold gold JJ cord-010119-t1x9gknd 5072 16 standard standard JJ cord-010119-t1x9gknd 5072 17 HPLC HPLC NNP cord-010119-t1x9gknd 5072 18 method method NN cord-010119-t1x9gknd 5072 19 using use VBG cord-010119-t1x9gknd 5072 20 variant variant JJ cord-010119-t1x9gknd 5072 21 II II NNP cord-010119-t1x9gknd 5072 22 Biorad Biorad NNP cord-010119-t1x9gknd 5072 23 . . . cord-010119-t1x9gknd 5073 1 Blood blood NN cord-010119-t1x9gknd 5073 2 donors donor NNS cord-010119-t1x9gknd 5073 3 with with IN cord-010119-t1x9gknd 5073 4 > > $ cord-010119-t1x9gknd 5073 5 180 180 CD cord-010119-t1x9gknd 5073 6 mg mg NNP cord-010119-t1x9gknd 5073 7 / / SYM cord-010119-t1x9gknd 5073 8 dl dl NNP cord-010119-t1x9gknd 5073 9 RBS RBS NNP cord-010119-t1x9gknd 5073 10 and and CC cord-010119-t1x9gknd 5073 11 HbA1c HbA1c NNP cord-010119-t1x9gknd 5073 12 > > SYM cord-010119-t1x9gknd 5073 13 6.5 6.5 CD cord-010119-t1x9gknd 5073 14 % % NN cord-010119-t1x9gknd 5073 15 were be VBD cord-010119-t1x9gknd 5073 16 advised advise VBN cord-010119-t1x9gknd 5073 17 to to TO cord-010119-t1x9gknd 5073 18 consult consult VB cord-010119-t1x9gknd 5073 19 a a DT cord-010119-t1x9gknd 5073 20 physician physician NN cord-010119-t1x9gknd 5073 21 for for IN cord-010119-t1x9gknd 5073 22 further further JJ cord-010119-t1x9gknd 5073 23 evaluation evaluation NN cord-010119-t1x9gknd 5073 24 . . . cord-010119-t1x9gknd 5074 1 Results result NNS cord-010119-t1x9gknd 5074 2 / / SYM cord-010119-t1x9gknd 5074 3 Findings finding NNS cord-010119-t1x9gknd 5074 4 : : : cord-010119-t1x9gknd 5074 5 Of of IN cord-010119-t1x9gknd 5074 6 the the DT cord-010119-t1x9gknd 5074 7 1,861 1,861 CD cord-010119-t1x9gknd 5074 8 donors donor NNS cord-010119-t1x9gknd 5074 9 tested test VBN cord-010119-t1x9gknd 5074 10 , , , cord-010119-t1x9gknd 5074 11 44 44 CD cord-010119-t1x9gknd 5074 12 ( ( -LRB- cord-010119-t1x9gknd 5074 13 2.36 2.36 CD cord-010119-t1x9gknd 5074 14 % % NN cord-010119-t1x9gknd 5074 15 ) ) -RRB- cord-010119-t1x9gknd 5074 16 donors donor NNS cord-010119-t1x9gknd 5074 17 showed show VBD cord-010119-t1x9gknd 5074 18 a a DT cord-010119-t1x9gknd 5074 19 RBS RBS NNP cord-010119-t1x9gknd 5074 20 of of IN cord-010119-t1x9gknd 5074 21 > > XX cord-010119-t1x9gknd 5075 1 180 180 CD cord-010119-t1x9gknd 5075 2 mg mg NNP cord-010119-t1x9gknd 5075 3 / / SYM cord-010119-t1x9gknd 5075 4 dl dl NN cord-010119-t1x9gknd 5075 5 . . . cord-010119-t1x9gknd 5076 1 Forty forty CD cord-010119-t1x9gknd 5076 2 two two CD cord-010119-t1x9gknd 5076 3 ( ( -LRB- cord-010119-t1x9gknd 5076 4 95.45 95.45 CD cord-010119-t1x9gknd 5076 5 % % NN cord-010119-t1x9gknd 5076 6 ) ) -RRB- cord-010119-t1x9gknd 5076 7 were be VBD cord-010119-t1x9gknd 5076 8 males male NNS cord-010119-t1x9gknd 5076 9 and and CC cord-010119-t1x9gknd 5076 10 2 2 CD cord-010119-t1x9gknd 5076 11 ( ( -LRB- cord-010119-t1x9gknd 5076 12 4.54 4.54 CD cord-010119-t1x9gknd 5076 13 % % NN cord-010119-t1x9gknd 5076 14 ) ) -RRB- cord-010119-t1x9gknd 5077 1 females female NNS cord-010119-t1x9gknd 5077 2 with with IN cord-010119-t1x9gknd 5077 3 a a DT cord-010119-t1x9gknd 5077 4 mean mean JJ cord-010119-t1x9gknd 5077 5 age age NN cord-010119-t1x9gknd 5077 6 of of IN cord-010119-t1x9gknd 5077 7 40.55 40.55 CD cord-010119-t1x9gknd 5077 8 years year NNS cord-010119-t1x9gknd 5077 9 ( ( -LRB- cord-010119-t1x9gknd 5077 10 26 26 CD cord-010119-t1x9gknd 5077 11 - - SYM cord-010119-t1x9gknd 5077 12 56 56 CD cord-010119-t1x9gknd 5077 13 years year NNS cord-010119-t1x9gknd 5077 14 ) ) -RRB- cord-010119-t1x9gknd 5077 15 . . . cord-010119-t1x9gknd 5078 1 Of of IN cord-010119-t1x9gknd 5078 2 these these DT cord-010119-t1x9gknd 5078 3 , , , cord-010119-t1x9gknd 5078 4 14 14 CD cord-010119-t1x9gknd 5078 5 ( ( -LRB- cord-010119-t1x9gknd 5078 6 31.81 31.81 CD cord-010119-t1x9gknd 5078 7 % % NN cord-010119-t1x9gknd 5078 8 ) ) -RRB- cord-010119-t1x9gknd 5078 9 were be VBD cord-010119-t1x9gknd 5078 10 known know VBN cord-010119-t1x9gknd 5078 11 case case NN cord-010119-t1x9gknd 5078 12 of of IN cord-010119-t1x9gknd 5078 13 Type Type NNP cord-010119-t1x9gknd 5078 14 - - HYPH cord-010119-t1x9gknd 5078 15 II II NNP cord-010119-t1x9gknd 5078 16 diabetes diabetes NN cord-010119-t1x9gknd 5078 17 mellitus mellitus NN cord-010119-t1x9gknd 5078 18 ( ( -LRB- cord-010119-t1x9gknd 5078 19 DM DM NNP cord-010119-t1x9gknd 5078 20 ) ) -RRB- cord-010119-t1x9gknd 5078 21 on on IN cord-010119-t1x9gknd 5078 22 oral oral JJ cord-010119-t1x9gknd 5078 23 medications medication NNS cord-010119-t1x9gknd 5078 24 and and CC cord-010119-t1x9gknd 5078 25 were be VBD cord-010119-t1x9gknd 5078 26 excluded exclude VBN cord-010119-t1x9gknd 5078 27 . . . cord-010119-t1x9gknd 5079 1 Of of IN cord-010119-t1x9gknd 5079 2 the the DT cord-010119-t1x9gknd 5079 3 remaining remain VBG cord-010119-t1x9gknd 5079 4 30 30 CD cord-010119-t1x9gknd 5079 5 , , , cord-010119-t1x9gknd 5079 6 8 8 CD cord-010119-t1x9gknd 5079 7 ( ( -LRB- cord-010119-t1x9gknd 5079 8 26.66 26.66 CD cord-010119-t1x9gknd 5079 9 % % NN cord-010119-t1x9gknd 5079 10 ) ) -RRB- cord-010119-t1x9gknd 5079 11 of of IN cord-010119-t1x9gknd 5079 12 them -PRON- PRP cord-010119-t1x9gknd 5079 13 had have VBD cord-010119-t1x9gknd 5079 14 a a DT cord-010119-t1x9gknd 5079 15 family family NN cord-010119-t1x9gknd 5079 16 history history NN cord-010119-t1x9gknd 5079 17 of of IN cord-010119-t1x9gknd 5079 18 DM DM NNP cord-010119-t1x9gknd 5079 19 . . . cord-010119-t1x9gknd 5080 1 Of of IN cord-010119-t1x9gknd 5080 2 these these DT cord-010119-t1x9gknd 5080 3 30 30 CD cord-010119-t1x9gknd 5080 4 donors donor NNS cord-010119-t1x9gknd 5080 5 , , , cord-010119-t1x9gknd 5080 6 8 8 CD cord-010119-t1x9gknd 5080 7 donors donor NNS cord-010119-t1x9gknd 5080 8 did do VBD cord-010119-t1x9gknd 5080 9 not not RB cord-010119-t1x9gknd 5080 10 give give VB cord-010119-t1x9gknd 5080 11 a a DT cord-010119-t1x9gknd 5080 12 consent consent NN cord-010119-t1x9gknd 5080 13 for for IN cord-010119-t1x9gknd 5080 14 testing testing NN cord-010119-t1x9gknd 5080 15 for for IN cord-010119-t1x9gknd 5080 16 HbA1c HbA1c NNP cord-010119-t1x9gknd 5080 17 . . . cord-010119-t1x9gknd 5081 1 Among among IN cord-010119-t1x9gknd 5081 2 the the DT cord-010119-t1x9gknd 5081 3 22 22 CD cord-010119-t1x9gknd 5081 4 donors donor NNS cord-010119-t1x9gknd 5081 5 tested test VBN cord-010119-t1x9gknd 5081 6 for for IN cord-010119-t1x9gknd 5081 7 HbA1c HbA1c NNP cord-010119-t1x9gknd 5081 8 levels level NNS cord-010119-t1x9gknd 5081 9 , , , cord-010119-t1x9gknd 5081 10 16 16 CD cord-010119-t1x9gknd 5081 11 ( ( -LRB- cord-010119-t1x9gknd 5081 12 72.72 72.72 CD cord-010119-t1x9gknd 5081 13 % % NN cord-010119-t1x9gknd 5081 14 ) ) -RRB- cord-010119-t1x9gknd 5081 15 had have VBD cord-010119-t1x9gknd 5081 16 HbA1c HbA1c NNS cord-010119-t1x9gknd 5081 17 > > SYM cord-010119-t1x9gknd 5081 18 6.5 6.5 CD cord-010119-t1x9gknd 5081 19 % % NN cord-010119-t1x9gknd 5081 20 . . . cord-010119-t1x9gknd 5082 1 All all PDT cord-010119-t1x9gknd 5082 2 the the DT cord-010119-t1x9gknd 5082 3 16 16 CD cord-010119-t1x9gknd 5082 4 donors donor NNS cord-010119-t1x9gknd 5082 5 were be VBD cord-010119-t1x9gknd 5082 6 counselled counsel VBN cord-010119-t1x9gknd 5082 7 and and CC cord-010119-t1x9gknd 5082 8 referred refer VBN cord-010119-t1x9gknd 5082 9 to to IN cord-010119-t1x9gknd 5082 10 a a DT cord-010119-t1x9gknd 5082 11 physician physician NN cord-010119-t1x9gknd 5082 12 for for IN cord-010119-t1x9gknd 5082 13 further further JJ cord-010119-t1x9gknd 5082 14 management management NN cord-010119-t1x9gknd 5082 15 . . . cord-010119-t1x9gknd 5083 1 The the DT cord-010119-t1x9gknd 5083 2 overall overall JJ cord-010119-t1x9gknd 5083 3 incidence incidence NN cord-010119-t1x9gknd 5083 4 of of IN cord-010119-t1x9gknd 5083 5 donors donor NNS cord-010119-t1x9gknd 5083 6 having have VBG cord-010119-t1x9gknd 5083 7 DM DM NNP cord-010119-t1x9gknd 5083 8 in in IN cord-010119-t1x9gknd 5083 9 the the DT cord-010119-t1x9gknd 5083 10 population population NN cord-010119-t1x9gknd 5083 11 is be VBZ cord-010119-t1x9gknd 5083 12 0.87 0.87 CD cord-010119-t1x9gknd 5083 13 % % NN cord-010119-t1x9gknd 5083 14 ( ( -LRB- cord-010119-t1x9gknd 5083 15 16 16 CD cord-010119-t1x9gknd 5083 16 of of IN cord-010119-t1x9gknd 5083 17 1839 1839 CD cord-010119-t1x9gknd 5083 18 donors donor NNS cord-010119-t1x9gknd 5083 19 ) ) -RRB- cord-010119-t1x9gknd 5083 20 . . . cord-010119-t1x9gknd 5084 1 Conclusion conclusion NN cord-010119-t1x9gknd 5084 2 : : : cord-010119-t1x9gknd 5084 3 Screening screening NN cord-010119-t1x9gknd 5084 4 for for IN cord-010119-t1x9gknd 5084 5 blood blood NN cord-010119-t1x9gknd 5084 6 glucose glucose NN cord-010119-t1x9gknd 5084 7 level level NN cord-010119-t1x9gknd 5084 8 by by IN cord-010119-t1x9gknd 5084 9 targeting target VBG cord-010119-t1x9gknd 5084 10 the the DT cord-010119-t1x9gknd 5084 11 blood blood NN cord-010119-t1x9gknd 5084 12 donors donor NNS cord-010119-t1x9gknd 5084 13 can can MD cord-010119-t1x9gknd 5084 14 go go VB cord-010119-t1x9gknd 5084 15 a a DT cord-010119-t1x9gknd 5084 16 long long JJ cord-010119-t1x9gknd 5084 17 way way NN cord-010119-t1x9gknd 5084 18 in in IN cord-010119-t1x9gknd 5084 19 curbing curb VBG cord-010119-t1x9gknd 5084 20 the the DT cord-010119-t1x9gknd 5084 21 diabetes diabetes NN cord-010119-t1x9gknd 5084 22 burden burden NN cord-010119-t1x9gknd 5084 23 on on IN cord-010119-t1x9gknd 5084 24 the the DT cord-010119-t1x9gknd 5084 25 society society NN cord-010119-t1x9gknd 5084 26 . . . cord-010119-t1x9gknd 5085 1 Incidence incidence NN cord-010119-t1x9gknd 5085 2 of of IN cord-010119-t1x9gknd 5085 3 Low low JJ cord-010119-t1x9gknd 5085 4 Ferritin Ferritin NNP cord-010119-t1x9gknd 5085 5 Levels Levels NNPS cord-010119-t1x9gknd 5085 6 in in IN cord-010119-t1x9gknd 5085 7 Regular regular JJ cord-010119-t1x9gknd 5085 8 Male Male NNP cord-010119-t1x9gknd 5085 9 Blood Blood NNP cord-010119-t1x9gknd 5085 10 Donors donor NNS cord-010119-t1x9gknd 5085 11 with with IN cord-010119-t1x9gknd 5085 12 Acceptable acceptable JJ cord-010119-t1x9gknd 5085 13 Hemoglobin hemoglobin NN cord-010119-t1x9gknd 5085 14 Levels Levels NNPS cord-010119-t1x9gknd 5085 15 in in IN cord-010119-t1x9gknd 5085 16 Singapore Singapore NNP cord-010119-t1x9gknd 5085 17 Ramir Ramir NNP cord-010119-t1x9gknd 5085 18 Alcantara Alcantara NNP cord-010119-t1x9gknd 5085 19 * * NFP cord-010119-t1x9gknd 5085 20 1 1 CD cord-010119-t1x9gknd 5085 21 , , , cord-010119-t1x9gknd 5085 22 Hwee Hwee NNP cord-010119-t1x9gknd 5085 23 huang huang NNP cord-010119-t1x9gknd 5085 24 Tan Tan NNP cord-010119-t1x9gknd 5085 25 1 1 CD cord-010119-t1x9gknd 5085 26 and and CC cord-010119-t1x9gknd 5086 1 Ai Ai NNP cord-010119-t1x9gknd 5086 2 Leen Leen NNP cord-010119-t1x9gknd 5086 3 Ang Ang NNP cord-010119-t1x9gknd 5086 4 2 2 CD cord-010119-t1x9gknd 5086 5 . . . cord-010119-t1x9gknd 5087 1 1 1 LS cord-010119-t1x9gknd 5088 1 Health Health NNP cord-010119-t1x9gknd 5088 2 Sciences Sciences NNPS cord-010119-t1x9gknd 5088 3 Authority Authority NNP cord-010119-t1x9gknd 5088 4 Blood Blood NNP cord-010119-t1x9gknd 5088 5 Services Services NNPS cord-010119-t1x9gknd 5088 6 Group Group NNP cord-010119-t1x9gknd 5088 7 , , , cord-010119-t1x9gknd 5088 8 2 2 CD cord-010119-t1x9gknd 5088 9 Health Health NNP cord-010119-t1x9gknd 5088 10 Sciences Sciences NNPS cord-010119-t1x9gknd 5088 11 Authority Authority NNP cord-010119-t1x9gknd 5088 12 , , , cord-010119-t1x9gknd 5088 13 Blood Blood NNP cord-010119-t1x9gknd 5088 14 Services Services NNPS cord-010119-t1x9gknd 5088 15 Group Group NNP cord-010119-t1x9gknd 5088 16 Background Background NNP cord-010119-t1x9gknd 5088 17 / / SYM cord-010119-t1x9gknd 5088 18 Case Case NNP cord-010119-t1x9gknd 5088 19 Studies Studies NNPS cord-010119-t1x9gknd 5089 1 : : : cord-010119-t1x9gknd 5089 2 Iron iron NN cord-010119-t1x9gknd 5089 3 deficiency deficiency NN cord-010119-t1x9gknd 5089 4 is be VBZ cord-010119-t1x9gknd 5089 5 a a DT cord-010119-t1x9gknd 5089 6 known know VBN cord-010119-t1x9gknd 5089 7 complication complication NN cord-010119-t1x9gknd 5089 8 of of IN cord-010119-t1x9gknd 5089 9 regular regular JJ cord-010119-t1x9gknd 5089 10 blood blood NN cord-010119-t1x9gknd 5089 11 donation donation NN cord-010119-t1x9gknd 5089 12 . . . cord-010119-t1x9gknd 5090 1 In in IN cord-010119-t1x9gknd 5090 2 order order NN cord-010119-t1x9gknd 5090 3 to to TO cord-010119-t1x9gknd 5090 4 protect protect VB cord-010119-t1x9gknd 5090 5 the the DT cord-010119-t1x9gknd 5090 6 donor donor NN cord-010119-t1x9gknd 5090 7 's 's POS cord-010119-t1x9gknd 5090 8 health health NN cord-010119-t1x9gknd 5090 9 and and CC cord-010119-t1x9gknd 5090 10 prevent prevent VB cord-010119-t1x9gknd 5090 11 iron iron NN cord-010119-t1x9gknd 5090 12 deficiency deficiency NN cord-010119-t1x9gknd 5090 13 , , , cord-010119-t1x9gknd 5090 14 AABB AABB NNP cord-010119-t1x9gknd 5090 15 increased increase VBD cord-010119-t1x9gknd 5090 16 the the DT cord-010119-t1x9gknd 5090 17 minimum minimum JJ cord-010119-t1x9gknd 5090 18 acceptable acceptable JJ cord-010119-t1x9gknd 5090 19 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5090 20 level level NN cord-010119-t1x9gknd 5090 21 for for IN cord-010119-t1x9gknd 5090 22 male male JJ cord-010119-t1x9gknd 5090 23 whole whole JJ cord-010119-t1x9gknd 5090 24 blood blood NN cord-010119-t1x9gknd 5090 25 and and CC cord-010119-t1x9gknd 5090 26 apheresis apheresis NN cord-010119-t1x9gknd 5090 27 donors donor NNS cord-010119-t1x9gknd 5090 28 from from IN cord-010119-t1x9gknd 5090 29 12.5 12.5 CD cord-010119-t1x9gknd 5090 30 to to IN cord-010119-t1x9gknd 5090 31 13.0 13.0 CD cord-010119-t1x9gknd 5090 32 g g NN cord-010119-t1x9gknd 5090 33 / / SYM cord-010119-t1x9gknd 5090 34 dl dl NN cord-010119-t1x9gknd 5090 35 last last JJ cord-010119-t1x9gknd 5090 36 May May NNP cord-010119-t1x9gknd 5090 37 2016 2016 CD cord-010119-t1x9gknd 5090 38 . . . cord-010119-t1x9gknd 5091 1 The the DT cord-010119-t1x9gknd 5091 2 current current JJ cord-010119-t1x9gknd 5091 3 minimum minimum JJ cord-010119-t1x9gknd 5091 4 acceptable acceptable JJ cord-010119-t1x9gknd 5091 5 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5091 6 for for IN cord-010119-t1x9gknd 5091 7 male male JJ cord-010119-t1x9gknd 5091 8 donors donor NNS cord-010119-t1x9gknd 5091 9 in in IN cord-010119-t1x9gknd 5091 10 Singapore Singapore NNP cord-010119-t1x9gknd 5091 11 is be VBZ cord-010119-t1x9gknd 5091 12 12.5 12.5 CD cord-010119-t1x9gknd 5091 13 g g NNP cord-010119-t1x9gknd 5091 14 / / SYM cord-010119-t1x9gknd 5091 15 dl dl NN cord-010119-t1x9gknd 5091 16 . . . cord-010119-t1x9gknd 5092 1 The the DT cord-010119-t1x9gknd 5092 2 aim aim NN cord-010119-t1x9gknd 5092 3 of of IN cord-010119-t1x9gknd 5092 4 the the DT cord-010119-t1x9gknd 5092 5 study study NN cord-010119-t1x9gknd 5092 6 is be VBZ cord-010119-t1x9gknd 5092 7 to to TO cord-010119-t1x9gknd 5092 8 determine determine VB cord-010119-t1x9gknd 5092 9 the the DT cord-010119-t1x9gknd 5092 10 incidence incidence NN cord-010119-t1x9gknd 5092 11 of of IN cord-010119-t1x9gknd 5092 12 low low JJ cord-010119-t1x9gknd 5092 13 ferritin ferritin NN cord-010119-t1x9gknd 5092 14 levels level NNS cord-010119-t1x9gknd 5092 15 in in IN cord-010119-t1x9gknd 5092 16 regular regular JJ cord-010119-t1x9gknd 5092 17 whole whole JJ cord-010119-t1x9gknd 5092 18 blood blood NN cord-010119-t1x9gknd 5092 19 and and CC cord-010119-t1x9gknd 5092 20 apheresis apheresis NN cord-010119-t1x9gknd 5092 21 male male JJ cord-010119-t1x9gknd 5092 22 blood blood NN cord-010119-t1x9gknd 5092 23 donors donor NNS cord-010119-t1x9gknd 5092 24 with with IN cord-010119-t1x9gknd 5092 25 acceptable acceptable JJ cord-010119-t1x9gknd 5092 26 borderline borderline JJ cord-010119-t1x9gknd 5092 27 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5092 28 levels level NNS cord-010119-t1x9gknd 5092 29 ( ( -LRB- cord-010119-t1x9gknd 5092 30 12.5 12.5 CD cord-010119-t1x9gknd 5092 31 - - SYM cord-010119-t1x9gknd 5092 32 12.9 12.9 CD cord-010119-t1x9gknd 5092 33 ) ) -RRB- cord-010119-t1x9gknd 5092 34 and and CC cord-010119-t1x9gknd 5092 35 in in IN cord-010119-t1x9gknd 5092 36 donors donor NNS cord-010119-t1x9gknd 5092 37 with with IN cord-010119-t1x9gknd 5092 38 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5092 39 13 13 CD cord-010119-t1x9gknd 5092 40 g g NN cord-010119-t1x9gknd 5092 41 / / SYM cord-010119-t1x9gknd 5092 42 dl dl NN cord-010119-t1x9gknd 5092 43 and and CC cord-010119-t1x9gknd 5092 44 above above RB cord-010119-t1x9gknd 5092 45 . . . cord-010119-t1x9gknd 5093 1 Study Study NNP cord-010119-t1x9gknd 5093 2 Design Design NNP cord-010119-t1x9gknd 5093 3 / / SYM cord-010119-t1x9gknd 5093 4 Method method NN cord-010119-t1x9gknd 5093 5 : : : cord-010119-t1x9gknd 5093 6 During during IN cord-010119-t1x9gknd 5093 7 a a DT cord-010119-t1x9gknd 5093 8 4 4 CD cord-010119-t1x9gknd 5093 9 month month NN cord-010119-t1x9gknd 5093 10 period period NN cord-010119-t1x9gknd 5093 11 , , , cord-010119-t1x9gknd 5093 12 serum serum NN cord-010119-t1x9gknd 5093 13 ferritin ferritin NN cord-010119-t1x9gknd 5093 14 testing testing NN cord-010119-t1x9gknd 5093 15 was be VBD cord-010119-t1x9gknd 5093 16 performed perform VBN cord-010119-t1x9gknd 5093 17 on on IN cord-010119-t1x9gknd 5093 18 350 350 CD cord-010119-t1x9gknd 5093 19 regular regular JJ cord-010119-t1x9gknd 5093 20 male male JJ cord-010119-t1x9gknd 5093 21 whole whole JJ cord-010119-t1x9gknd 5093 22 blood blood NN cord-010119-t1x9gknd 5093 23 and and CC cord-010119-t1x9gknd 5093 24 250 250 CD cord-010119-t1x9gknd 5093 25 regular regular JJ cord-010119-t1x9gknd 5093 26 male male JJ cord-010119-t1x9gknd 5093 27 apheresis apheresis NN cord-010119-t1x9gknd 5093 28 donors donor NNS cord-010119-t1x9gknd 5093 29 who who WP cord-010119-t1x9gknd 5093 30 made make VBD cord-010119-t1x9gknd 5093 31 at at IN cord-010119-t1x9gknd 5093 32 least least JJS cord-010119-t1x9gknd 5093 33 3 3 CD cord-010119-t1x9gknd 5093 34 donations donation NNS cord-010119-t1x9gknd 5093 35 in in IN cord-010119-t1x9gknd 5093 36 the the DT cord-010119-t1x9gknd 5093 37 last last JJ cord-010119-t1x9gknd 5093 38 two two CD cord-010119-t1x9gknd 5093 39 years year NNS cord-010119-t1x9gknd 5093 40 with with IN cord-010119-t1x9gknd 5093 41 an an DT cord-010119-t1x9gknd 5093 42 acceptable acceptable JJ cord-010119-t1x9gknd 5093 43 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5093 44 level level NN cord-010119-t1x9gknd 5093 45 . . . cord-010119-t1x9gknd 5094 1 The the DT cord-010119-t1x9gknd 5094 2 donors donor NNS cord-010119-t1x9gknd 5094 3 were be VBD cord-010119-t1x9gknd 5094 4 divided divide VBN cord-010119-t1x9gknd 5094 5 into into IN cord-010119-t1x9gknd 5094 6 groups group NNS cord-010119-t1x9gknd 5094 7 according accord VBG cord-010119-t1x9gknd 5094 8 to to IN cord-010119-t1x9gknd 5094 9 donation donation NN cord-010119-t1x9gknd 5094 10 type type NN cord-010119-t1x9gknd 5094 11 and and CC cord-010119-t1x9gknd 5094 12 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5094 13 range range NN cord-010119-t1x9gknd 5094 14 ; ; : cord-010119-t1x9gknd 5094 15 Group Group NNP cord-010119-t1x9gknd 5094 16 A A NNP cord-010119-t1x9gknd 5094 17 ( ( -LRB- cord-010119-t1x9gknd 5094 18 whole whole JJ cord-010119-t1x9gknd 5094 19 blood blood NN cord-010119-t1x9gknd 5094 20 with with IN cord-010119-t1x9gknd 5094 21 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5094 22 12.5 12.5 CD cord-010119-t1x9gknd 5094 23 - - HYPH cord-010119-t1x9gknd 5094 24 12.9 12.9 CD cord-010119-t1x9gknd 5094 25 ) ) -RRB- cord-010119-t1x9gknd 5095 1 Group Group NNP cord-010119-t1x9gknd 5095 2 B B NNP cord-010119-t1x9gknd 5095 3 ( ( -LRB- cord-010119-t1x9gknd 5095 4 whole whole JJ cord-010119-t1x9gknd 5095 5 blood blood NN cord-010119-t1x9gknd 5095 6 with with IN cord-010119-t1x9gknd 5095 7 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5095 8 ! ! . cord-010119-t1x9gknd 5096 1 13 13 CD cord-010119-t1x9gknd 5096 2 , , , cord-010119-t1x9gknd 5096 3 Group Group NNP cord-010119-t1x9gknd 5096 4 C C NNP cord-010119-t1x9gknd 5096 5 ( ( -LRB- cord-010119-t1x9gknd 5096 6 apheresis apheresis NN cord-010119-t1x9gknd 5096 7 with with IN cord-010119-t1x9gknd 5096 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5096 9 12.5 12.5 CD cord-010119-t1x9gknd 5096 10 - - HYPH cord-010119-t1x9gknd 5096 11 12.9 12.9 CD cord-010119-t1x9gknd 5096 12 ) ) -RRB- cord-010119-t1x9gknd 5096 13 and and CC cord-010119-t1x9gknd 5096 14 Group Group NNP cord-010119-t1x9gknd 5096 15 D D NNP cord-010119-t1x9gknd 5096 16 ( ( -LRB- cord-010119-t1x9gknd 5096 17 apheresis apheresis NN cord-010119-t1x9gknd 5096 18 with with IN cord-010119-t1x9gknd 5096 19 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5096 20 ! ! . cord-010119-t1x9gknd 5096 21 13 13 CD cord-010119-t1x9gknd 5096 22 ) ) -RRB- cord-010119-t1x9gknd 5096 23 . . . cord-010119-t1x9gknd 5097 1 The the DT cord-010119-t1x9gknd 5097 2 serum serum NN cord-010119-t1x9gknd 5097 3 ferritin ferritin NN cord-010119-t1x9gknd 5097 4 levels level NNS cord-010119-t1x9gknd 5097 5 of of IN cord-010119-t1x9gknd 5097 6 the the DT cord-010119-t1x9gknd 5097 7 four four CD cord-010119-t1x9gknd 5097 8 donor donor NN cord-010119-t1x9gknd 5097 9 groups group NNS cord-010119-t1x9gknd 5097 10 were be VBD cord-010119-t1x9gknd 5097 11 compared compare VBN cord-010119-t1x9gknd 5097 12 and and CC cord-010119-t1x9gknd 5097 13 analyzed analyze VBN cord-010119-t1x9gknd 5097 14 . . . cord-010119-t1x9gknd 5098 1 A a DT cord-010119-t1x9gknd 5098 2 ferritin ferritin NN cord-010119-t1x9gknd 5098 3 level level NN cord-010119-t1x9gknd 5098 4 below below IN cord-010119-t1x9gknd 5098 5 30 30 CD cord-010119-t1x9gknd 5098 6 ug ug NNP cord-010119-t1x9gknd 5098 7 / / SYM cord-010119-t1x9gknd 5098 8 L L NNP cord-010119-t1x9gknd 5098 9 is be VBZ cord-010119-t1x9gknd 5098 10 considered consider VBN cord-010119-t1x9gknd 5098 11 low low JJ cord-010119-t1x9gknd 5098 12 and and CC cord-010119-t1x9gknd 5098 13 levels level NNS cord-010119-t1x9gknd 5098 14 below below IN cord-010119-t1x9gknd 5098 15 < < XX cord-010119-t1x9gknd 5098 16 12 12 CD cord-010119-t1x9gknd 5099 1 ug ug NNP cord-010119-t1x9gknd 5099 2 / / SYM cord-010119-t1x9gknd 5099 3 L L NNP cord-010119-t1x9gknd 5099 4 are be VBP cord-010119-t1x9gknd 5099 5 considered consider VBN cord-010119-t1x9gknd 5099 6 having have VBG cord-010119-t1x9gknd 5099 7 absent absent JJ cord-010119-t1x9gknd 5099 8 iron iron NN cord-010119-t1x9gknd 5099 9 stores store NNS cord-010119-t1x9gknd 5099 10 . . . cord-010119-t1x9gknd 5100 1 Results result NNS cord-010119-t1x9gknd 5100 2 / / SYM cord-010119-t1x9gknd 5100 3 Findings finding NNS cord-010119-t1x9gknd 5100 4 : : : cord-010119-t1x9gknd 5101 1 55.1 55.1 CD cord-010119-t1x9gknd 5101 2 % % NN cord-010119-t1x9gknd 5101 3 of of IN cord-010119-t1x9gknd 5101 4 donors donor NNS cord-010119-t1x9gknd 5101 5 in in IN cord-010119-t1x9gknd 5101 6 the the DT cord-010119-t1x9gknd 5101 7 study study NN cord-010119-t1x9gknd 5101 8 have have VBP cord-010119-t1x9gknd 5101 9 ferritin ferritin NN cord-010119-t1x9gknd 5101 10 levels level NNS cord-010119-t1x9gknd 5101 11 below below RB cord-010119-t1x9gknd 5102 1 30 30 CD cord-010119-t1x9gknd 5102 2 ug ug NNP cord-010119-t1x9gknd 5102 3 / / SYM cord-010119-t1x9gknd 5102 4 L. L. NNP cord-010119-t1x9gknd 5102 5 There there EX cord-010119-t1x9gknd 5102 6 were be VBD cord-010119-t1x9gknd 5102 7 more more JJR cord-010119-t1x9gknd 5102 8 donors donor NNS cord-010119-t1x9gknd 5102 9 with with IN cord-010119-t1x9gknd 5102 10 low low JJ cord-010119-t1x9gknd 5102 11 ferritin ferritin NN cord-010119-t1x9gknd 5102 12 in in IN cord-010119-t1x9gknd 5102 13 group group NN cord-010119-t1x9gknd 5102 14 A a NN cord-010119-t1x9gknd 5102 15 compared compare VBN cord-010119-t1x9gknd 5102 16 to to IN cord-010119-t1x9gknd 5102 17 group group NN cord-010119-t1x9gknd 5102 18 B b NN cord-010119-t1x9gknd 5102 19 , , , cord-010119-t1x9gknd 5102 20 80 80 CD cord-010119-t1x9gknd 5102 21 % % NN cord-010119-t1x9gknd 5102 22 and and CC cord-010119-t1x9gknd 5102 23 53 53 CD cord-010119-t1x9gknd 5102 24 % % NN cord-010119-t1x9gknd 5102 25 respectively respectively RB cord-010119-t1x9gknd 5102 26 ( ( -LRB- cord-010119-t1x9gknd 5102 27 p<0.05 p<0.05 CD cord-010119-t1x9gknd 5102 28 ) ) -RRB- cord-010119-t1x9gknd 5102 29 . . . cord-010119-t1x9gknd 5103 1 In in IN cord-010119-t1x9gknd 5103 2 apheresis apheresis NN cord-010119-t1x9gknd 5103 3 donors donor NNS cord-010119-t1x9gknd 5103 4 , , , cord-010119-t1x9gknd 5103 5 low low JJ cord-010119-t1x9gknd 5103 6 ferritin ferritin NN cord-010119-t1x9gknd 5103 7 rates rate NNS cord-010119-t1x9gknd 5103 8 were be VBD cord-010119-t1x9gknd 5103 9 higher high JJR cord-010119-t1x9gknd 5103 10 in in IN cord-010119-t1x9gknd 5103 11 group group NN cord-010119-t1x9gknd 5103 12 C c NN cord-010119-t1x9gknd 5103 13 donors donor NNS cord-010119-t1x9gknd 5103 14 compared compare VBN cord-010119-t1x9gknd 5103 15 with with IN cord-010119-t1x9gknd 5103 16 group group NN cord-010119-t1x9gknd 5103 17 D d NN cord-010119-t1x9gknd 5103 18 , , , cord-010119-t1x9gknd 5103 19 49 49 CD cord-010119-t1x9gknd 5103 20 % % NN cord-010119-t1x9gknd 5103 21 and and CC cord-010119-t1x9gknd 5103 22 30 30 CD cord-010119-t1x9gknd 5103 23 % % NN cord-010119-t1x9gknd 5103 24 respectively respectively RB cord-010119-t1x9gknd 5103 25 ( ( -LRB- cord-010119-t1x9gknd 5103 26 p50.001876 p50.001876 NNP cord-010119-t1x9gknd 5103 27 ) ) -RRB- cord-010119-t1x9gknd 5103 28 . . . cord-010119-t1x9gknd 5104 1 Ferritin ferritin NN cord-010119-t1x9gknd 5104 2 results result VBZ cord-010119-t1x9gknd 5104 3 for for IN cord-010119-t1x9gknd 5104 4 the the DT cord-010119-t1x9gknd 5104 5 4 4 CD cord-010119-t1x9gknd 5104 6 groups group NNS cord-010119-t1x9gknd 5104 7 can can MD cord-010119-t1x9gknd 5104 8 be be VB cord-010119-t1x9gknd 5104 9 seen see VBN cord-010119-t1x9gknd 5104 10 in in IN cord-010119-t1x9gknd 5104 11 table table NN cord-010119-t1x9gknd 5104 12 1 1 CD cord-010119-t1x9gknd 5104 13 . . . cord-010119-t1x9gknd 5105 1 Conclusion conclusion NN cord-010119-t1x9gknd 5105 2 : : : cord-010119-t1x9gknd 5106 1 More More JJR cord-010119-t1x9gknd 5106 2 than than IN cord-010119-t1x9gknd 5106 3 half half NN cord-010119-t1x9gknd 5106 4 of of IN cord-010119-t1x9gknd 5106 5 the the DT cord-010119-t1x9gknd 5106 6 donors donor NNS cord-010119-t1x9gknd 5106 7 in in IN cord-010119-t1x9gknd 5106 8 the the DT cord-010119-t1x9gknd 5106 9 study study NN cord-010119-t1x9gknd 5106 10 have have VBP cord-010119-t1x9gknd 5106 11 low low JJ cord-010119-t1x9gknd 5106 12 ferritin ferritin NN cord-010119-t1x9gknd 5106 13 and and CC cord-010119-t1x9gknd 5106 14 of of IN cord-010119-t1x9gknd 5106 15 the the DT cord-010119-t1x9gknd 5106 16 donors donor NNS cord-010119-t1x9gknd 5106 17 with with IN cord-010119-t1x9gknd 5106 18 low low JJ cord-010119-t1x9gknd 5106 19 ferritin ferritin NN cord-010119-t1x9gknd 5106 20 , , , cord-010119-t1x9gknd 5106 21 more more JJR cord-010119-t1x9gknd 5106 22 than than IN cord-010119-t1x9gknd 5106 23 half half NN cord-010119-t1x9gknd 5106 24 or or CC cord-010119-t1x9gknd 5106 25 54.3 54.3 CD cord-010119-t1x9gknd 5106 26 % % NN cord-010119-t1x9gknd 5106 27 have have VBP cord-010119-t1x9gknd 5106 28 absent absent JJ cord-010119-t1x9gknd 5106 29 iron iron NN cord-010119-t1x9gknd 5106 30 stores store NNS cord-010119-t1x9gknd 5106 31 . . . cord-010119-t1x9gknd 5107 1 Donors donor NNS cord-010119-t1x9gknd 5107 2 with with IN cord-010119-t1x9gknd 5107 3 low low JJ cord-010119-t1x9gknd 5107 4 ferritin ferritin NN cord-010119-t1x9gknd 5107 5 were be VBD cord-010119-t1x9gknd 5107 6 immediately immediately RB cord-010119-t1x9gknd 5107 7 informed inform VBN cord-010119-t1x9gknd 5107 8 of of IN cord-010119-t1x9gknd 5107 9 their -PRON- PRP$ cord-010119-t1x9gknd 5107 10 result result NN cord-010119-t1x9gknd 5107 11 , , , cord-010119-t1x9gknd 5107 12 given give VBN cord-010119-t1x9gknd 5107 13 iron iron NN cord-010119-t1x9gknd 5107 14 supplements supplement NNS cord-010119-t1x9gknd 5107 15 and and CC cord-010119-t1x9gknd 5107 16 advised advise VBD cord-010119-t1x9gknd 5107 17 to to TO cord-010119-t1x9gknd 5107 18 come come VB cord-010119-t1x9gknd 5107 19 back back RB cord-010119-t1x9gknd 5107 20 for for IN cord-010119-t1x9gknd 5107 21 donation donation NN cord-010119-t1x9gknd 5107 22 after after IN cord-010119-t1x9gknd 5107 23 4 4 CD cord-010119-t1x9gknd 5107 24 months month NNS cord-010119-t1x9gknd 5107 25 or or CC cord-010119-t1x9gknd 5107 26 more more JJR cord-010119-t1x9gknd 5107 27 . . . cord-010119-t1x9gknd 5108 1 Since since IN cord-010119-t1x9gknd 5108 2 donor donor NN cord-010119-t1x9gknd 5108 3 health health NN cord-010119-t1x9gknd 5108 4 and and CC cord-010119-t1x9gknd 5108 5 safety safety NN cord-010119-t1x9gknd 5108 6 is be VBZ cord-010119-t1x9gknd 5108 7 of of IN cord-010119-t1x9gknd 5108 8 paramount paramount JJ cord-010119-t1x9gknd 5108 9 importance importance NN cord-010119-t1x9gknd 5108 10 , , , cord-010119-t1x9gknd 5108 11 measures measure NNS cord-010119-t1x9gknd 5108 12 to to TO cord-010119-t1x9gknd 5108 13 limit limit VB cord-010119-t1x9gknd 5108 14 and and CC cord-010119-t1x9gknd 5108 15 prevent prevent VB cord-010119-t1x9gknd 5108 16 iron iron NN cord-010119-t1x9gknd 5108 17 deficiency deficiency NN cord-010119-t1x9gknd 5108 18 in in IN cord-010119-t1x9gknd 5108 19 blood blood NN cord-010119-t1x9gknd 5108 20 donors donor NNS cord-010119-t1x9gknd 5108 21 must must MD cord-010119-t1x9gknd 5108 22 be be VB cord-010119-t1x9gknd 5108 23 implemented implement VBN cord-010119-t1x9gknd 5108 24 . . . cord-010119-t1x9gknd 5109 1 Due due IN cord-010119-t1x9gknd 5109 2 to to IN cord-010119-t1x9gknd 5109 3 the the DT cord-010119-t1x9gknd 5109 4 high high JJ cord-010119-t1x9gknd 5109 5 incidence incidence NN cord-010119-t1x9gknd 5109 6 of of IN cord-010119-t1x9gknd 5109 7 low low JJ cord-010119-t1x9gknd 5109 8 ferritin ferritin NN cord-010119-t1x9gknd 5109 9 levels level NNS cord-010119-t1x9gknd 5109 10 in in IN cord-010119-t1x9gknd 5109 11 whole whole JJ cord-010119-t1x9gknd 5109 12 blood blood NN cord-010119-t1x9gknd 5109 13 and and CC cord-010119-t1x9gknd 5109 14 apheresis apheresis NN cord-010119-t1x9gknd 5109 15 donors donor NNS cord-010119-t1x9gknd 5109 16 with with IN cord-010119-t1x9gknd 5109 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5109 18 12.5 12.5 CD cord-010119-t1x9gknd 5109 19 - - HYPH cord-010119-t1x9gknd 5109 20 12.9 12.9 CD cord-010119-t1x9gknd 5109 21 g g NNP cord-010119-t1x9gknd 5109 22 / / SYM cord-010119-t1x9gknd 5109 23 dl dl NNP cord-010119-t1x9gknd 5109 24 , , , cord-010119-t1x9gknd 5109 25 it -PRON- PRP cord-010119-t1x9gknd 5109 26 is be VBZ cord-010119-t1x9gknd 5109 27 recommended recommend VBN cord-010119-t1x9gknd 5109 28 that that IN cord-010119-t1x9gknd 5109 29 the the DT cord-010119-t1x9gknd 5109 30 minimum minimum JJ cord-010119-t1x9gknd 5109 31 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5109 32 level level NN cord-010119-t1x9gknd 5109 33 cut cut VBN cord-010119-t1x9gknd 5109 34 off off RP cord-010119-t1x9gknd 5109 35 for for IN cord-010119-t1x9gknd 5109 36 male male JJ cord-010119-t1x9gknd 5109 37 blood blood NN cord-010119-t1x9gknd 5109 38 donors donor NNS cord-010119-t1x9gknd 5109 39 in in IN cord-010119-t1x9gknd 5109 40 Singapore Singapore NNP cord-010119-t1x9gknd 5109 41 be be VB cord-010119-t1x9gknd 5109 42 increased increase VBN cord-010119-t1x9gknd 5109 43 to to IN cord-010119-t1x9gknd 5109 44 13.0 13.0 CD cord-010119-t1x9gknd 5109 45 g g NN cord-010119-t1x9gknd 5109 46 / / SYM cord-010119-t1x9gknd 5109 47 dl dl NN cord-010119-t1x9gknd 5109 48 . . . cord-010119-t1x9gknd 5110 1 Other other JJ cord-010119-t1x9gknd 5110 2 measures measure NNS cord-010119-t1x9gknd 5110 3 to to TO cord-010119-t1x9gknd 5110 4 be be VB cord-010119-t1x9gknd 5110 5 implemented implement VBN cord-010119-t1x9gknd 5110 6 includes include VBZ cord-010119-t1x9gknd 5110 7 better well JJR cord-010119-t1x9gknd 5110 8 donor donor NN cord-010119-t1x9gknd 5110 9 education education NN cord-010119-t1x9gknd 5110 10 on on IN cord-010119-t1x9gknd 5110 11 the the DT cord-010119-t1x9gknd 5110 12 risk risk NN cord-010119-t1x9gknd 5110 13 of of IN cord-010119-t1x9gknd 5110 14 iron iron NN cord-010119-t1x9gknd 5110 15 deficiency deficiency NN cord-010119-t1x9gknd 5110 16 and and CC cord-010119-t1x9gknd 5110 17 the the DT cord-010119-t1x9gknd 5110 18 need need NN cord-010119-t1x9gknd 5110 19 for for IN cord-010119-t1x9gknd 5110 20 iron iron NN cord-010119-t1x9gknd 5110 21 supplementation supplementation NN cord-010119-t1x9gknd 5110 22 using use VBG cord-010119-t1x9gknd 5110 23 our -PRON- PRP$ cord-010119-t1x9gknd 5110 24 website website NN cord-010119-t1x9gknd 5110 25 and and CC cord-010119-t1x9gknd 5110 26 social social JJ cord-010119-t1x9gknd 5110 27 media medium NNS cord-010119-t1x9gknd 5110 28 . . . cord-010119-t1x9gknd 5111 1 Background Background NNP cord-010119-t1x9gknd 5111 2 / / SYM cord-010119-t1x9gknd 5111 3 Case Case NNP cord-010119-t1x9gknd 5111 4 Studies Studies NNPS cord-010119-t1x9gknd 5112 1 : : : cord-010119-t1x9gknd 5112 2 Safe safe JJ cord-010119-t1x9gknd 5112 3 blood blood NN cord-010119-t1x9gknd 5112 4 is be VBZ cord-010119-t1x9gknd 5112 5 a a DT cord-010119-t1x9gknd 5112 6 crucial crucial JJ cord-010119-t1x9gknd 5112 7 and and CC cord-010119-t1x9gknd 5112 8 irreplaceable irreplaceable JJ cord-010119-t1x9gknd 5112 9 component component NN cord-010119-t1x9gknd 5112 10 in in IN cord-010119-t1x9gknd 5112 11 the the DT cord-010119-t1x9gknd 5112 12 medical medical JJ cord-010119-t1x9gknd 5112 13 management management NN cord-010119-t1x9gknd 5112 14 of of IN cord-010119-t1x9gknd 5112 15 many many JJ cord-010119-t1x9gknd 5112 16 diseases disease NNS cord-010119-t1x9gknd 5112 17 . . . cord-010119-t1x9gknd 5113 1 The the DT cord-010119-t1x9gknd 5113 2 Voluntary Voluntary NNP cord-010119-t1x9gknd 5113 3 nonremunerated nonremunerate VBN cord-010119-t1x9gknd 5113 4 blood blood NN cord-010119-t1x9gknd 5113 5 donation donation NN cord-010119-t1x9gknd 5113 6 is be VBZ cord-010119-t1x9gknd 5113 7 the the DT cord-010119-t1x9gknd 5113 8 ideal ideal JJ cord-010119-t1x9gknd 5113 9 sources source NNS cord-010119-t1x9gknd 5113 10 of of IN cord-010119-t1x9gknd 5113 11 quality quality NN cord-010119-t1x9gknd 5113 12 blood blood NN cord-010119-t1x9gknd 5113 13 , , , cord-010119-t1x9gknd 5113 14 which which WDT cord-010119-t1x9gknd 5113 15 forms form VBZ cord-010119-t1x9gknd 5113 16 less less JJR cord-010119-t1x9gknd 5113 17 than than IN cord-010119-t1x9gknd 5113 18 15 15 CD cord-010119-t1x9gknd 5113 19 % % NN cord-010119-t1x9gknd 5113 20 of of IN cord-010119-t1x9gknd 5113 21 the the DT cord-010119-t1x9gknd 5113 22 demand demand NN cord-010119-t1x9gknd 5113 23 of of IN cord-010119-t1x9gknd 5113 24 the the DT cord-010119-t1x9gknd 5113 25 blood blood NN cord-010119-t1x9gknd 5113 26 in in IN cord-010119-t1x9gknd 5113 27 Pakistan Pakistan NNP cord-010119-t1x9gknd 5113 28 . . . cord-010119-t1x9gknd 5114 1 Motivation motivation NN cord-010119-t1x9gknd 5114 2 among among IN cord-010119-t1x9gknd 5114 3 the the DT cord-010119-t1x9gknd 5114 4 youth youth NN cord-010119-t1x9gknd 5114 5 , , , cord-010119-t1x9gknd 5114 6 particularly particularly RB cord-010119-t1x9gknd 5114 7 students student NNS cord-010119-t1x9gknd 5114 8 , , , cord-010119-t1x9gknd 5114 9 is be VBZ cord-010119-t1x9gknd 5114 10 essential essential JJ cord-010119-t1x9gknd 5114 11 to to TO cord-010119-t1x9gknd 5114 12 make make VB cord-010119-t1x9gknd 5114 13 voluntary voluntary JJ cord-010119-t1x9gknd 5114 14 blood blood NN cord-010119-t1x9gknd 5114 15 movement movement NN cord-010119-t1x9gknd 5114 16 more more RBR cord-010119-t1x9gknd 5114 17 successful successful JJ cord-010119-t1x9gknd 5114 18 . . . cord-010119-t1x9gknd 5115 1 To to TO cord-010119-t1x9gknd 5115 2 assess assess VB cord-010119-t1x9gknd 5115 3 the the DT cord-010119-t1x9gknd 5115 4 knowledge knowledge NN cord-010119-t1x9gknd 5115 5 , , , cord-010119-t1x9gknd 5115 6 attitude attitude NN cord-010119-t1x9gknd 5115 7 and and CC cord-010119-t1x9gknd 5115 8 practice practice NN cord-010119-t1x9gknd 5115 9 regarding regard VBG cord-010119-t1x9gknd 5115 10 the the DT cord-010119-t1x9gknd 5115 11 voluntary voluntary JJ cord-010119-t1x9gknd 5115 12 blood blood NN cord-010119-t1x9gknd 5115 13 donation donation NN cord-010119-t1x9gknd 5115 14 among among IN cord-010119-t1x9gknd 5115 15 the the DT cord-010119-t1x9gknd 5115 16 young young JJ cord-010119-t1x9gknd 5115 17 student student NN cord-010119-t1x9gknd 5115 18 population population NN cord-010119-t1x9gknd 5115 19 of of IN cord-010119-t1x9gknd 5115 20 Karachi Karachi NNP cord-010119-t1x9gknd 5115 21 so so IN cord-010119-t1x9gknd 5115 22 that that IN cord-010119-t1x9gknd 5115 23 an an DT cord-010119-t1x9gknd 5115 24 effective effective JJ cord-010119-t1x9gknd 5115 25 approach approach NN cord-010119-t1x9gknd 5115 26 can can MD cord-010119-t1x9gknd 5115 27 be be VB cord-010119-t1x9gknd 5115 28 made make VBN cord-010119-t1x9gknd 5115 29 regarding regard VBG cord-010119-t1x9gknd 5115 30 motivation motivation NN cord-010119-t1x9gknd 5115 31 enrolment enrolment NN cord-010119-t1x9gknd 5115 32 of of IN cord-010119-t1x9gknd 5115 33 voluntary voluntary JJ cord-010119-t1x9gknd 5115 34 non non JJ cord-010119-t1x9gknd 5115 35 remunerated remunerated JJ cord-010119-t1x9gknd 5115 36 blood blood NN cord-010119-t1x9gknd 5115 37 donors donor NNS cord-010119-t1x9gknd 5115 38 in in IN cord-010119-t1x9gknd 5115 39 future future NN cord-010119-t1x9gknd 5115 40 in in IN cord-010119-t1x9gknd 5115 41 Pakistan Pakistan NNP cord-010119-t1x9gknd 5115 42 Study Study NNP cord-010119-t1x9gknd 5115 43 Design Design NNP cord-010119-t1x9gknd 5115 44 / / SYM cord-010119-t1x9gknd 5115 45 Method method NN cord-010119-t1x9gknd 5115 46 : : : cord-010119-t1x9gknd 5116 1 A a DT cord-010119-t1x9gknd 5116 2 cross cross JJ cord-010119-t1x9gknd 5116 3 sectional sectional JJ cord-010119-t1x9gknd 5116 4 prospective prospective JJ cord-010119-t1x9gknd 5116 5 study study NN cord-010119-t1x9gknd 5116 6 was be VBD cord-010119-t1x9gknd 5116 7 conducted conduct VBN cord-010119-t1x9gknd 5116 8 among among IN cord-010119-t1x9gknd 5116 9 600 600 CD cord-010119-t1x9gknd 5116 10 students student NNS cord-010119-t1x9gknd 5116 11 from from IN cord-010119-t1x9gknd 5116 12 different different JJ cord-010119-t1x9gknd 5116 13 universities university NNS cord-010119-t1x9gknd 5116 14 and and CC cord-010119-t1x9gknd 5116 15 colleges college NNS cord-010119-t1x9gknd 5116 16 of of IN cord-010119-t1x9gknd 5116 17 Karachi Karachi NNP cord-010119-t1x9gknd 5116 18 . . . cord-010119-t1x9gknd 5117 1 A a DT cord-010119-t1x9gknd 5117 2 well well RB cord-010119-t1x9gknd 5117 3 - - HYPH cord-010119-t1x9gknd 5117 4 structured structure VBN cord-010119-t1x9gknd 5117 5 and and CC cord-010119-t1x9gknd 5117 6 pre pre JJ cord-010119-t1x9gknd 5117 7 - - JJ cord-010119-t1x9gknd 5117 8 tested test VBN cord-010119-t1x9gknd 5117 9 questionnaire questionnaire NN cord-010119-t1x9gknd 5117 10 , , , cord-010119-t1x9gknd 5117 11 in in IN cord-010119-t1x9gknd 5117 12 English English NNP cord-010119-t1x9gknd 5117 13 , , , cord-010119-t1x9gknd 5117 14 was be VBD cord-010119-t1x9gknd 5117 15 used use VBN cord-010119-t1x9gknd 5117 16 to to TO cord-010119-t1x9gknd 5117 17 access access VB cord-010119-t1x9gknd 5117 18 the the DT cord-010119-t1x9gknd 5117 19 knowledge knowledge NN cord-010119-t1x9gknd 5117 20 , , , cord-010119-t1x9gknd 5117 21 attitudes attitude NNS cord-010119-t1x9gknd 5117 22 and and CC cord-010119-t1x9gknd 5117 23 practices practice NNS cord-010119-t1x9gknd 5117 24 about about IN cord-010119-t1x9gknd 5117 25 voluntary voluntary JJ cord-010119-t1x9gknd 5117 26 blood blood NN cord-010119-t1x9gknd 5117 27 donation donation NN cord-010119-t1x9gknd 5117 28 . . . cord-010119-t1x9gknd 5118 1 A a DT cord-010119-t1x9gknd 5118 2 scoring scoring NN cord-010119-t1x9gknd 5118 3 mechanism mechanism NN cord-010119-t1x9gknd 5118 4 was be VBD cord-010119-t1x9gknd 5118 5 used use VBN cord-010119-t1x9gknd 5118 6 to to TO cord-010119-t1x9gknd 5118 7 understand understand VB cord-010119-t1x9gknd 5118 8 overall overall JJ cord-010119-t1x9gknd 5118 9 knowledge knowledge NN cord-010119-t1x9gknd 5118 10 level level NN cord-010119-t1x9gknd 5118 11 . . . cord-010119-t1x9gknd 5119 1 Obtained obtain VBN cord-010119-t1x9gknd 5119 2 data datum NNS cord-010119-t1x9gknd 5119 3 was be VBD cord-010119-t1x9gknd 5119 4 analyzed analyze VBN cord-010119-t1x9gknd 5119 5 . . . cord-010119-t1x9gknd 5120 1 Results/ Results/ . cord-010119-t1x9gknd 5121 1 Finding find VBG cord-010119-t1x9gknd 5121 2 : : : cord-010119-t1x9gknd 5121 3 The the DT cord-010119-t1x9gknd 5121 4 sample sample NN cord-010119-t1x9gknd 5121 5 population population NN cord-010119-t1x9gknd 5121 6 consisted consist VBD cord-010119-t1x9gknd 5121 7 of of IN cord-010119-t1x9gknd 5121 8 54 54 CD cord-010119-t1x9gknd 5121 9 % % NN cord-010119-t1x9gknd 5121 10 male male NN cord-010119-t1x9gknd 5121 11 and and CC cord-010119-t1x9gknd 5121 12 46 46 CD cord-010119-t1x9gknd 5121 13 % % NN cord-010119-t1x9gknd 5121 14 female female JJ cord-010119-t1x9gknd 5121 15 students student NNS cord-010119-t1x9gknd 5121 16 in in IN cord-010119-t1x9gknd 5121 17 the the DT cord-010119-t1x9gknd 5121 18 age age NN cord-010119-t1x9gknd 5121 19 group group NN cord-010119-t1x9gknd 5121 20 of of IN cord-010119-t1x9gknd 5121 21 18 18 CD cord-010119-t1x9gknd 5121 22 - - SYM cord-010119-t1x9gknd 5121 23 28 28 CD cord-010119-t1x9gknd 5121 24 years year NNS cord-010119-t1x9gknd 5121 25 . . . cord-010119-t1x9gknd 5122 1 Only only RB cord-010119-t1x9gknd 5122 2 65 65 CD cord-010119-t1x9gknd 5122 3 % % NN cord-010119-t1x9gknd 5122 4 of of IN cord-010119-t1x9gknd 5122 5 the the DT cord-010119-t1x9gknd 5122 6 students student NNS cord-010119-t1x9gknd 5122 7 have have VBP cord-010119-t1x9gknd 5122 8 heard hear VBN cord-010119-t1x9gknd 5122 9 about about IN cord-010119-t1x9gknd 5122 10 voluntary voluntary JJ cord-010119-t1x9gknd 5122 11 blood blood NN cord-010119-t1x9gknd 5122 12 donation donation NN cord-010119-t1x9gknd 5122 13 and and CC cord-010119-t1x9gknd 5122 14 28 28 CD cord-010119-t1x9gknd 5122 15 % % NN cord-010119-t1x9gknd 5122 16 of of IN cord-010119-t1x9gknd 5122 17 the the DT cord-010119-t1x9gknd 5122 18 students student NNS cord-010119-t1x9gknd 5122 19 have have VBP cord-010119-t1x9gknd 5122 20 given give VBN cord-010119-t1x9gknd 5122 21 blood blood NN cord-010119-t1x9gknd 5122 22 once once RB cord-010119-t1x9gknd 5122 23 in in IN cord-010119-t1x9gknd 5122 24 their -PRON- PRP$ cord-010119-t1x9gknd 5122 25 lifetime lifetime NN cord-010119-t1x9gknd 5122 26 and and CC cord-010119-t1x9gknd 5123 1 among among IN cord-010119-t1x9gknd 5123 2 them -PRON- PRP cord-010119-t1x9gknd 5123 3 19 19 CD cord-010119-t1x9gknd 5123 4 % % NN cord-010119-t1x9gknd 5123 5 are be VBP cord-010119-t1x9gknd 5123 6 blood blood NN cord-010119-t1x9gknd 5123 7 donors donor NNS cord-010119-t1x9gknd 5123 8 at at IN cord-010119-t1x9gknd 5123 9 the the DT cord-010119-t1x9gknd 5123 10 moment moment NN cord-010119-t1x9gknd 5123 11 . . . cord-010119-t1x9gknd 5124 1 42 42 CD cord-010119-t1x9gknd 5124 2 % % NN cord-010119-t1x9gknd 5124 3 of of IN cord-010119-t1x9gknd 5124 4 the the DT cord-010119-t1x9gknd 5124 5 participants participant NNS cord-010119-t1x9gknd 5124 6 believed believe VBD cord-010119-t1x9gknd 5124 7 that that IN cord-010119-t1x9gknd 5124 8 there there EX cord-010119-t1x9gknd 5124 9 is be VBZ cord-010119-t1x9gknd 5124 10 a a DT cord-010119-t1x9gknd 5124 11 specific specific JJ cord-010119-t1x9gknd 5124 12 reason reason NN cord-010119-t1x9gknd 5124 13 why why WRB cord-010119-t1x9gknd 5124 14 they -PRON- PRP cord-010119-t1x9gknd 5124 15 do do VBP cord-010119-t1x9gknd 5124 16 n't not RB cord-010119-t1x9gknd 5124 17 donate donate VB cord-010119-t1x9gknd 5124 18 blood blood NN cord-010119-t1x9gknd 5124 19 and and CC cord-010119-t1x9gknd 5124 20 59 59 CD cord-010119-t1x9gknd 5124 21 % % NN cord-010119-t1x9gknd 5124 22 believed believe VBD cord-010119-t1x9gknd 5124 23 that that IN cord-010119-t1x9gknd 5124 24 there there EX cord-010119-t1x9gknd 5124 25 is be VBZ cord-010119-t1x9gknd 5124 26 a a DT cord-010119-t1x9gknd 5124 27 risk risk NN cord-010119-t1x9gknd 5124 28 involved involve VBN cord-010119-t1x9gknd 5124 29 for for IN cord-010119-t1x9gknd 5124 30 the the DT cord-010119-t1x9gknd 5124 31 donors donor NNS cord-010119-t1x9gknd 5124 32 , , , cord-010119-t1x9gknd 5124 33 when when WRB cord-010119-t1x9gknd 5124 34 donating donate VBG cord-010119-t1x9gknd 5124 35 blood blood NN cord-010119-t1x9gknd 5124 36 . . . cord-010119-t1x9gknd 5125 1 80 80 CD cord-010119-t1x9gknd 5125 2 % % NN cord-010119-t1x9gknd 5125 3 students student NNS cord-010119-t1x9gknd 5125 4 wanted want VBD cord-010119-t1x9gknd 5125 5 to to TO cord-010119-t1x9gknd 5125 6 promote promote VB cord-010119-t1x9gknd 5125 7 voluntary voluntary JJ cord-010119-t1x9gknd 5125 8 blood blood NN cord-010119-t1x9gknd 5125 9 donation donation NN cord-010119-t1x9gknd 5125 10 . . . cord-010119-t1x9gknd 5126 1 Fear fear NN cord-010119-t1x9gknd 5126 2 and and CC cord-010119-t1x9gknd 5126 3 lack lack NN cord-010119-t1x9gknd 5126 4 of of IN cord-010119-t1x9gknd 5126 5 awareness awareness NN cord-010119-t1x9gknd 5126 6 on on IN cord-010119-t1x9gknd 5126 7 blood blood NN cord-010119-t1x9gknd 5126 8 donation donation NN cord-010119-t1x9gknd 5126 9 are be VBP cord-010119-t1x9gknd 5126 10 the the DT cord-010119-t1x9gknd 5126 11 reasons reason NNS cord-010119-t1x9gknd 5126 12 for for IN cord-010119-t1x9gknd 5126 13 not not RB cord-010119-t1x9gknd 5126 14 donating donate VBG cord-010119-t1x9gknd 5126 15 blood blood NN cord-010119-t1x9gknd 5126 16 . . . cord-010119-t1x9gknd 5127 1 Students student NNS cord-010119-t1x9gknd 5127 2 gather gather VBP cord-010119-t1x9gknd 5127 3 information information NN cord-010119-t1x9gknd 5127 4 about about IN cord-010119-t1x9gknd 5127 5 voluntary voluntary JJ cord-010119-t1x9gknd 5127 6 blood blood NN cord-010119-t1x9gknd 5127 7 donation donation NN cord-010119-t1x9gknd 5127 8 from from IN cord-010119-t1x9gknd 5127 9 several several JJ cord-010119-t1x9gknd 5127 10 sources source NNS cord-010119-t1x9gknd 5128 1 mostly mostly RB cord-010119-t1x9gknd 5128 2 schools school NNS cord-010119-t1x9gknd 5128 3 , , , cord-010119-t1x9gknd 5128 4 colleges college NNS cord-010119-t1x9gknd 5128 5 , , , cord-010119-t1x9gknd 5128 6 family family NN cord-010119-t1x9gknd 5128 7 and and CC cord-010119-t1x9gknd 5128 8 friends friend NNS cord-010119-t1x9gknd 5128 9 . . . cord-010119-t1x9gknd 5129 1 ( ( -LRB- cord-010119-t1x9gknd 5129 2 21 21 CD cord-010119-t1x9gknd 5129 3 ) ) -RRB- cord-010119-t1x9gknd 5129 4 ; ; : cord-010119-t1x9gknd 5129 5 miscellaneous miscellaneous JJ cord-010119-t1x9gknd 5129 6 effects effect NNS cord-010119-t1x9gknd 5129 7 were be VBD cord-010119-t1x9gknd 5129 8 reported report VBN cord-010119-t1x9gknd 5129 9 in in IN cord-010119-t1x9gknd 5129 10 23 23 CD cord-010119-t1x9gknd 5129 11 courses course NNS cord-010119-t1x9gknd 5129 12 . . . cord-010119-t1x9gknd 5130 1 Side side JJ cord-010119-t1x9gknd 5130 2 effects effect NNS cord-010119-t1x9gknd 5130 3 led lead VBD cord-010119-t1x9gknd 5130 4 to to IN cord-010119-t1x9gknd 5130 5 interruption interruption NN cord-010119-t1x9gknd 5130 6 of of IN cord-010119-t1x9gknd 5130 7 supplementation supplementation NN cord-010119-t1x9gknd 5130 8 in in IN cord-010119-t1x9gknd 5130 9 55 55 CD cord-010119-t1x9gknd 5130 10 instances instance NNS cord-010119-t1x9gknd 5130 11 . . . cord-010119-t1x9gknd 5131 1 Ferritin ferritin NN cord-010119-t1x9gknd 5131 2 levels level NNS cord-010119-t1x9gknd 5131 3 ( ( -LRB- cord-010119-t1x9gknd 5131 4 MGT6SD MGT6SD NNP cord-010119-t1x9gknd 5131 5 ) ) -RRB- cord-010119-t1x9gknd 5131 6 at at IN cord-010119-t1x9gknd 5131 7 entry entry NN cord-010119-t1x9gknd 5131 8 into into IN cord-010119-t1x9gknd 5131 9 the the DT cord-010119-t1x9gknd 5131 10 program program NN cord-010119-t1x9gknd 5131 11 and and CC cord-010119-t1x9gknd 5131 12 at at IN cord-010119-t1x9gknd 5131 13 the the DT cord-010119-t1x9gknd 5131 14 last last JJ cord-010119-t1x9gknd 5131 15 visit visit NN cord-010119-t1x9gknd 5131 16 were be VBD cord-010119-t1x9gknd 5131 17 48.9 48.9 CD cord-010119-t1x9gknd 5131 18 6 6 CD cord-010119-t1x9gknd 5131 19 2 2 CD cord-010119-t1x9gknd 5131 20 and and CC cord-010119-t1x9gknd 5131 21 65.4 65.4 CD cord-010119-t1x9gknd 5131 22 6 6 CD cord-010119-t1x9gknd 5131 23 1.7 1.7 CD cord-010119-t1x9gknd 5131 24 mg mg NNP cord-010119-t1x9gknd 5131 25 / / SYM cord-010119-t1x9gknd 5131 26 L l NN cord-010119-t1x9gknd 5131 27 in in IN cord-010119-t1x9gknd 5131 28 participants participant NNS cord-010119-t1x9gknd 5131 29 , , , cord-010119-t1x9gknd 5131 30 vs vs IN cord-010119-t1x9gknd 5131 31 64.1 64.1 CD cord-010119-t1x9gknd 5131 32 6 6 CD cord-010119-t1x9gknd 5131 33 2.2 2.2 CD cord-010119-t1x9gknd 5131 34 and and CC cord-010119-t1x9gknd 5131 35 56.3 56.3 CD cord-010119-t1x9gknd 5131 36 6 6 CD cord-010119-t1x9gknd 5131 37 2.2 2.2 CD cord-010119-t1x9gknd 5131 38 mg mg NNP cord-010119-t1x9gknd 5131 39 / / SYM cord-010119-t1x9gknd 5131 40 L L NNP cord-010119-t1x9gknd 5131 41 in in IN cord-010119-t1x9gknd 5131 42 controls control NNS cord-010119-t1x9gknd 5131 43 . . . cord-010119-t1x9gknd 5132 1 The the DT cord-010119-t1x9gknd 5132 2 positive positive JJ cord-010119-t1x9gknd 5132 3 impact impact NN cord-010119-t1x9gknd 5132 4 of of IN cord-010119-t1x9gknd 5132 5 iron iron NN cord-010119-t1x9gknd 5132 6 supplementation supplementation NN cord-010119-t1x9gknd 5132 7 on on IN cord-010119-t1x9gknd 5132 8 ferritin ferritin NN cord-010119-t1x9gknd 5132 9 levels level NNS cord-010119-t1x9gknd 5132 10 was be VBD cord-010119-t1x9gknd 5132 11 observed observe VBN cord-010119-t1x9gknd 5132 12 only only RB cord-010119-t1x9gknd 5132 13 in in IN cord-010119-t1x9gknd 5132 14 those those DT cord-010119-t1x9gknd 5132 15 who who WP cord-010119-t1x9gknd 5132 16 took take VBD cord-010119-t1x9gknd 5132 17 ! ! . cord-010119-t1x9gknd 5133 1 75 75 CD cord-010119-t1x9gknd 5133 2 % % NN cord-010119-t1x9gknd 5133 3 of of IN cord-010119-t1x9gknd 5133 4 the the DT cord-010119-t1x9gknd 5133 5 tablets tablet NNS cord-010119-t1x9gknd 5133 6 . . . cord-010119-t1x9gknd 5134 1 Ferritin ferritin NN cord-010119-t1x9gknd 5134 2 levels<26mg levels<26mg NNS cord-010119-t1x9gknd 5134 3 / / SYM cord-010119-t1x9gknd 5134 4 L L NNP cord-010119-t1x9gknd 5134 5 were be VBD cord-010119-t1x9gknd 5134 6 found find VBN cord-010119-t1x9gknd 5134 7 in in IN cord-010119-t1x9gknd 5134 8 4,8 4,8 CD cord-010119-t1x9gknd 5134 9 % % NN cord-010119-t1x9gknd 5134 10 of of IN cord-010119-t1x9gknd 5134 11 participants participant NNS cord-010119-t1x9gknd 5134 12 and and CC cord-010119-t1x9gknd 5134 13 14.7 14.7 CD cord-010119-t1x9gknd 5134 14 % % NN cord-010119-t1x9gknd 5134 15 of of IN cord-010119-t1x9gknd 5134 16 controls control NNS cord-010119-t1x9gknd 5134 17 . . . cord-010119-t1x9gknd 5135 1 Deferral deferral NN cord-010119-t1x9gknd 5135 2 for for IN cord-010119-t1x9gknd 5135 3 low low JJ cord-010119-t1x9gknd 5135 4 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5135 5 was be VBD cord-010119-t1x9gknd 5135 6 below below IN cord-010119-t1x9gknd 5135 7 1 1 CD cord-010119-t1x9gknd 5135 8 % % NN cord-010119-t1x9gknd 5135 9 in in IN cord-010119-t1x9gknd 5135 10 both both DT cord-010119-t1x9gknd 5135 11 groups group NNS cord-010119-t1x9gknd 5135 12 . . . cord-010119-t1x9gknd 5136 1 Conclusion conclusion NN cord-010119-t1x9gknd 5136 2 : : : cord-010119-t1x9gknd 5137 1 An an DT cord-010119-t1x9gknd 5137 2 iron iron NN cord-010119-t1x9gknd 5137 3 supplementation supplementation NN cord-010119-t1x9gknd 5137 4 program program NN cord-010119-t1x9gknd 5137 5 in in IN cord-010119-t1x9gknd 5137 6 a a DT cord-010119-t1x9gknd 5137 7 DRBCD DRBCD NNP cord-010119-t1x9gknd 5137 8 program program NN cord-010119-t1x9gknd 5137 9 is be VBZ cord-010119-t1x9gknd 5137 10 feasible feasible JJ cord-010119-t1x9gknd 5137 11 . . . cord-010119-t1x9gknd 5138 1 However however RB cord-010119-t1x9gknd 5138 2 , , , cord-010119-t1x9gknd 5138 3 when when WRB cord-010119-t1x9gknd 5138 4 taking take VBG cord-010119-t1x9gknd 5138 5 into into IN cord-010119-t1x9gknd 5138 6 account account NN cord-010119-t1x9gknd 5138 7 acceptance acceptance NN cord-010119-t1x9gknd 5138 8 to to TO cord-010119-t1x9gknd 5138 9 participate participate VB cord-010119-t1x9gknd 5138 10 and and CC cord-010119-t1x9gknd 5138 11 compliance compliance NN cord-010119-t1x9gknd 5138 12 with with IN cord-010119-t1x9gknd 5138 13 supplementation supplementation NN cord-010119-t1x9gknd 5138 14 , , , cord-010119-t1x9gknd 5138 15 only only RB cord-010119-t1x9gknd 5138 16 50 50 CD cord-010119-t1x9gknd 5138 17 % % NN cord-010119-t1x9gknd 5138 18 of of IN cord-010119-t1x9gknd 5138 19 donors donor NNS cord-010119-t1x9gknd 5138 20 obtain obtain VBP cord-010119-t1x9gknd 5138 21 full full JJ cord-010119-t1x9gknd 5138 22 benefit benefit NN cord-010119-t1x9gknd 5138 23 from from IN cord-010119-t1x9gknd 5138 24 such such PDT cord-010119-t1x9gknd 5138 25 a a DT cord-010119-t1x9gknd 5138 26 program program NN cord-010119-t1x9gknd 5138 27 . . . cord-010119-t1x9gknd 5139 1 Using use VBG cord-010119-t1x9gknd 5139 2 an an DT cord-010119-t1x9gknd 5139 3 iron iron NN cord-010119-t1x9gknd 5139 4 preparation preparation NN cord-010119-t1x9gknd 5139 5 which which WDT cord-010119-t1x9gknd 5139 6 is be VBZ cord-010119-t1x9gknd 5139 7 better well RBR cord-010119-t1x9gknd 5139 8 tolerated tolerate VBN cord-010119-t1x9gknd 5139 9 may may MD cord-010119-t1x9gknd 5139 10 increase increase VB cord-010119-t1x9gknd 5139 11 compliance compliance NN cord-010119-t1x9gknd 5139 12 . . . cord-010119-t1x9gknd 5140 1 Background Background NNP cord-010119-t1x9gknd 5140 2 / / SYM cord-010119-t1x9gknd 5140 3 Case Case NNP cord-010119-t1x9gknd 5140 4 Studies Studies NNPS cord-010119-t1x9gknd 5140 5 : : : cord-010119-t1x9gknd 5141 1 Hereditary Hereditary NNP cord-010119-t1x9gknd 5141 2 Hemochromatosis Hemochromatosis NNP cord-010119-t1x9gknd 5141 3 ( ( -LRB- cord-010119-t1x9gknd 5141 4 HH HH NNP cord-010119-t1x9gknd 5141 5 ) ) -RRB- cord-010119-t1x9gknd 5141 6 patients patient NNS cord-010119-t1x9gknd 5141 7 are be VBP cord-010119-t1x9gknd 5141 8 permitted permit VBN cord-010119-t1x9gknd 5141 9 to to TO cord-010119-t1x9gknd 5141 10 donate donate VB cord-010119-t1x9gknd 5141 11 blood blood NN cord-010119-t1x9gknd 5141 12 for for IN cord-010119-t1x9gknd 5141 13 the the DT cord-010119-t1x9gknd 5141 14 allogeneic allogeneic NN cord-010119-t1x9gknd 5141 15 blood blood NN cord-010119-t1x9gknd 5141 16 supply supply NN cord-010119-t1x9gknd 5141 17 as as RB cord-010119-t1x9gknd 5141 18 long long RB cord-010119-t1x9gknd 5141 19 as as IN cord-010119-t1x9gknd 5141 20 they -PRON- PRP cord-010119-t1x9gknd 5141 21 are be VBP cord-010119-t1x9gknd 5141 22 eligible eligible JJ cord-010119-t1x9gknd 5141 23 for for IN cord-010119-t1x9gknd 5141 24 donation donation NN cord-010119-t1x9gknd 5141 25 under under IN cord-010119-t1x9gknd 5141 26 21CFR630.10 21cfr630.10 CD cord-010119-t1x9gknd 5141 27 and and CC cord-010119-t1x9gknd 5141 28 the the DT cord-010119-t1x9gknd 5141 29 collection collection NN cord-010119-t1x9gknd 5141 30 is be VBZ cord-010119-t1x9gknd 5141 31 a a DT cord-010119-t1x9gknd 5141 32 physician physician NN cord-010119-t1x9gknd 5141 33 - - HYPH cord-010119-t1x9gknd 5141 34 ordered order VBN cord-010119-t1x9gknd 5141 35 therapeutic therapeutic JJ cord-010119-t1x9gknd 5141 36 phlebotomy phlebotomy NN cord-010119-t1x9gknd 5141 37 . . . cord-010119-t1x9gknd 5142 1 Blood blood NN cord-010119-t1x9gknd 5142 2 collections collection NNS cord-010119-t1x9gknd 5142 3 Establishments establishment NNS cord-010119-t1x9gknd 5142 4 do do VBP cord-010119-t1x9gknd 5142 5 not not RB cord-010119-t1x9gknd 5142 6 need need VB cord-010119-t1x9gknd 5142 7 an an DT cord-010119-t1x9gknd 5142 8 exception exception NN cord-010119-t1x9gknd 5142 9 or or CC cord-010119-t1x9gknd 5142 10 alternative alternative NN cord-010119-t1x9gknd 5142 11 under under IN cord-010119-t1x9gknd 5142 12 § § CD cord-010119-t1x9gknd 5142 13 640.120 640.120 CD cord-010119-t1x9gknd 5142 14 to to TO cord-010119-t1x9gknd 5142 15 make make VB cord-010119-t1x9gknd 5142 16 a a DT cord-010119-t1x9gknd 5142 17 collection collection NN cord-010119-t1x9gknd 5142 18 under under IN cord-010119-t1x9gknd 5142 19 this this DT cord-010119-t1x9gknd 5142 20 provision provision NN cord-010119-t1x9gknd 5142 21 if if IN cord-010119-t1x9gknd 5142 22 the the DT cord-010119-t1x9gknd 5142 23 requirements requirement NNS cord-010119-t1x9gknd 5142 24 set set VBN cord-010119-t1x9gknd 5142 25 forth forth RP cord-010119-t1x9gknd 5142 26 in in IN cord-010119-t1x9gknd 5142 27 § § CD cord-010119-t1x9gknd 5142 28 630.15(a)(2 630.15(a)(2 NNP cord-010119-t1x9gknd 5142 29 ) ) -RRB- cord-010119-t1x9gknd 5142 30 are be VBP cord-010119-t1x9gknd 5142 31 met meet VBN cord-010119-t1x9gknd 5142 32 . . . cord-010119-t1x9gknd 5143 1 The the DT cord-010119-t1x9gknd 5143 2 objective objective NN cord-010119-t1x9gknd 5143 3 is be VBZ cord-010119-t1x9gknd 5143 4 to to TO cord-010119-t1x9gknd 5143 5 describe describe VB cord-010119-t1x9gknd 5143 6 current current JJ cord-010119-t1x9gknd 5143 7 HH HH NNP cord-010119-t1x9gknd 5143 8 donors donor NNS cord-010119-t1x9gknd 5143 9 and and CC cord-010119-t1x9gknd 5143 10 long long JJ cord-010119-t1x9gknd 5143 11 - - HYPH cord-010119-t1x9gknd 5143 12 term term NN cord-010119-t1x9gknd 5143 13 contributions contribution NNS cord-010119-t1x9gknd 5143 14 of of IN cord-010119-t1x9gknd 5143 15 to to IN cord-010119-t1x9gknd 5143 16 our -PRON- PRP$ cord-010119-t1x9gknd 5143 17 hospital hospital NN cord-010119-t1x9gknd 5143 18 - - HYPH cord-010119-t1x9gknd 5143 19 based base VBN cord-010119-t1x9gknd 5143 20 donor donor NN cord-010119-t1x9gknd 5143 21 center center NN cord-010119-t1x9gknd 5143 22 and and CC cord-010119-t1x9gknd 5143 23 hospital hospital NN cord-010119-t1x9gknd 5143 24 blood blood NN cord-010119-t1x9gknd 5143 25 supply supply NN cord-010119-t1x9gknd 5143 26 . . . cord-010119-t1x9gknd 5144 1 Study Study NNP cord-010119-t1x9gknd 5144 2 Design Design NNP cord-010119-t1x9gknd 5144 3 / / SYM cord-010119-t1x9gknd 5144 4 Method method NN cord-010119-t1x9gknd 5144 5 : : : cord-010119-t1x9gknd 5145 1 In in IN cord-010119-t1x9gknd 5145 2 2001 2001 CD cord-010119-t1x9gknd 5145 3 , , , cord-010119-t1x9gknd 5145 4 an an DT cord-010119-t1x9gknd 5145 5 IRB IRB NNP cord-010119-t1x9gknd 5145 6 protocol protocol NN cord-010119-t1x9gknd 5145 7 was be VBD cord-010119-t1x9gknd 5145 8 approved approve VBN cord-010119-t1x9gknd 5145 9 for for IN cord-010119-t1x9gknd 5145 10 the the DT cord-010119-t1x9gknd 5145 11 enrollment enrollment NN cord-010119-t1x9gknd 5145 12 and and CC cord-010119-t1x9gknd 5145 13 therapeutic therapeutic JJ cord-010119-t1x9gknd 5145 14 phlebotomy phlebotomy NN cord-010119-t1x9gknd 5145 15 of of IN cord-010119-t1x9gknd 5145 16 HH HH NNP cord-010119-t1x9gknd 5145 17 patients patient NNS cord-010119-t1x9gknd 5145 18 / / SYM cord-010119-t1x9gknd 5145 19 subjects subject NNS cord-010119-t1x9gknd 5145 20 . . . cord-010119-t1x9gknd 5146 1 This this DT cord-010119-t1x9gknd 5146 2 required require VBD cord-010119-t1x9gknd 5146 3 filing file VBG cord-010119-t1x9gknd 5146 4 an an DT cord-010119-t1x9gknd 5146 5 FDA FDA NNP cord-010119-t1x9gknd 5146 6 variance variance NN cord-010119-t1x9gknd 5146 7 to to TO cord-010119-t1x9gknd 5146 8 permit permit VB cord-010119-t1x9gknd 5146 9 HH HH NNP cord-010119-t1x9gknd 5146 10 donor donor NN cord-010119-t1x9gknd 5146 11 blood blood NN cord-010119-t1x9gknd 5146 12 for for IN cord-010119-t1x9gknd 5146 13 use use NN cord-010119-t1x9gknd 5146 14 in in IN cord-010119-t1x9gknd 5146 15 our -PRON- PRP$ cord-010119-t1x9gknd 5146 16 allogeneic allogeneic NN cord-010119-t1x9gknd 5146 17 supply supply NN cord-010119-t1x9gknd 5146 18 without without IN cord-010119-t1x9gknd 5146 19 disease disease NN cord-010119-t1x9gknd 5146 20 labeling labeling NN cord-010119-t1x9gknd 5146 21 . . . cord-010119-t1x9gknd 5147 1 The the DT cord-010119-t1x9gknd 5147 2 frequency frequency NN cord-010119-t1x9gknd 5147 3 of of IN cord-010119-t1x9gknd 5147 4 therapeutic therapeutic JJ cord-010119-t1x9gknd 5147 5 bleeds bleed NNS cord-010119-t1x9gknd 5147 6 are be VBP cord-010119-t1x9gknd 5147 7 guided guide VBN cord-010119-t1x9gknd 5147 8 by by IN cord-010119-t1x9gknd 5147 9 routine routine JJ cord-010119-t1x9gknd 5147 10 clinical clinical JJ cord-010119-t1x9gknd 5147 11 assessment assessment NN cord-010119-t1x9gknd 5147 12 , , , cord-010119-t1x9gknd 5147 13 MCV MCV NNP cord-010119-t1x9gknd 5147 14 / / SYM cord-010119-t1x9gknd 5147 15 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5147 16 , , , cord-010119-t1x9gknd 5147 17 serum serum NN cord-010119-t1x9gknd 5147 18 ferritin ferritin NN cord-010119-t1x9gknd 5147 19 , , , cord-010119-t1x9gknd 5147 20 and and CC cord-010119-t1x9gknd 5147 21 transferrin transferrin NN cord-010119-t1x9gknd 5147 22 % % NN cord-010119-t1x9gknd 5147 23 saturation saturation NN cord-010119-t1x9gknd 5147 24 monitoring monitoring NN cord-010119-t1x9gknd 5147 25 . . . cord-010119-t1x9gknd 5148 1 Serum serum NN cord-010119-t1x9gknd 5148 2 ferritin ferritin NN cord-010119-t1x9gknd 5148 3 levels level NNS cord-010119-t1x9gknd 5148 4 of of IN cord-010119-t1x9gknd 5148 5 50 50 CD cord-010119-t1x9gknd 5148 6 -75 -75 NN cord-010119-t1x9gknd 5148 7 ng/ ng/ NN cord-010119-t1x9gknd 5148 8 mL mL NNP cord-010119-t1x9gknd 5148 9 are be VBP cord-010119-t1x9gknd 5148 10 targeted target VBN cord-010119-t1x9gknd 5148 11 for for IN cord-010119-t1x9gknd 5148 12 maintenance maintenance NN cord-010119-t1x9gknd 5148 13 phlebotomy phlebotomy NN cord-010119-t1x9gknd 5148 14 . . . cord-010119-t1x9gknd 5149 1 Operationally operationally RB cord-010119-t1x9gknd 5149 2 , , , cord-010119-t1x9gknd 5149 3 a a DT cord-010119-t1x9gknd 5149 4 custom custom NN cord-010119-t1x9gknd 5149 5 , , , cord-010119-t1x9gknd 5149 6 computerized computerized JJ cord-010119-t1x9gknd 5149 7 database database NN cord-010119-t1x9gknd 5149 8 application application NN cord-010119-t1x9gknd 5149 9 is be VBZ cord-010119-t1x9gknd 5149 10 employed employ VBN cord-010119-t1x9gknd 5149 11 to to TO cord-010119-t1x9gknd 5149 12 ease ease VB cord-010119-t1x9gknd 5149 13 phlebotomy phlebotomy NN cord-010119-t1x9gknd 5149 14 management management NN cord-010119-t1x9gknd 5149 15 . . . cord-010119-t1x9gknd 5150 1 Results result NNS cord-010119-t1x9gknd 5150 2 / / SYM cord-010119-t1x9gknd 5150 3 Finding finding NN cord-010119-t1x9gknd 5150 4 : : : cord-010119-t1x9gknd 5151 1 Since since IN cord-010119-t1x9gknd 5151 2 inception inception NN cord-010119-t1x9gknd 5151 3 , , , cord-010119-t1x9gknd 5151 4 the the DT cord-010119-t1x9gknd 5151 5 cumulative cumulative JJ cord-010119-t1x9gknd 5151 6 number number NN cord-010119-t1x9gknd 5151 7 of of IN cord-010119-t1x9gknd 5151 8 HH HH NNP cord-010119-t1x9gknd 5151 9 subjects subject NNS cord-010119-t1x9gknd 5151 10 enrolled enrol VBN cord-010119-t1x9gknd 5151 11 in in IN cord-010119-t1x9gknd 5151 12 the the DT cord-010119-t1x9gknd 5151 13 hemochromatosis hemochromatosis NN cord-010119-t1x9gknd 5151 14 protocol protocol NN cord-010119-t1x9gknd 5151 15 reached reach VBD cord-010119-t1x9gknd 5151 16 547 547 CD cord-010119-t1x9gknd 5151 17 , , , cord-010119-t1x9gknd 5151 18 of of IN cord-010119-t1x9gknd 5151 19 whom whom WP cord-010119-t1x9gknd 5151 20 365 365 CD cord-010119-t1x9gknd 5151 21 ( ( -LRB- cord-010119-t1x9gknd 5151 22 67 67 CD cord-010119-t1x9gknd 5151 23 % % NN cord-010119-t1x9gknd 5151 24 ) ) -RRB- cord-010119-t1x9gknd 5151 25 are be VBP cord-010119-t1x9gknd 5151 26 C282Y c282y JJ cord-010119-t1x9gknd 5151 27 homozygotes homozygote NNS cord-010119-t1x9gknd 5151 28 . . . cord-010119-t1x9gknd 5152 1 Without without IN cord-010119-t1x9gknd 5152 2 active active JJ cord-010119-t1x9gknd 5152 3 recruitment recruitment NN cord-010119-t1x9gknd 5152 4 , , , cord-010119-t1x9gknd 5152 5 accrual accrual NN cord-010119-t1x9gknd 5152 6 rate rate NN cord-010119-t1x9gknd 5152 7 is be VBZ cord-010119-t1x9gknd 5152 8 about about RB cord-010119-t1x9gknd 5152 9 7 7 CD cord-010119-t1x9gknd 5152 10 per per IN cord-010119-t1x9gknd 5152 11 quarter quarter NN cord-010119-t1x9gknd 5152 12 , , , cord-010119-t1x9gknd 5152 13 with with IN cord-010119-t1x9gknd 5152 14 69 69 CD cord-010119-t1x9gknd 5152 15 % % NN cord-010119-t1x9gknd 5152 16 of of IN cord-010119-t1x9gknd 5152 17 subjects subject NNS cord-010119-t1x9gknd 5152 18 qualifying qualify VBG cord-010119-t1x9gknd 5152 19 as as IN cord-010119-t1x9gknd 5152 20 allogeneic allogeneic NN cord-010119-t1x9gknd 5152 21 donors donor NNS cord-010119-t1x9gknd 5152 22 . . . cord-010119-t1x9gknd 5153 1 The the DT cord-010119-t1x9gknd 5153 2 mean mean JJ cord-010119-t1x9gknd 5153 3 current current JJ cord-010119-t1x9gknd 5153 4 age age NN cord-010119-t1x9gknd 5153 5 is be VBZ cord-010119-t1x9gknd 5153 6 59.7 59.7 CD cord-010119-t1x9gknd 5153 7 years year NNS cord-010119-t1x9gknd 5153 8 , , , cord-010119-t1x9gknd 5153 9 65 65 CD cord-010119-t1x9gknd 5153 10 % % NN cord-010119-t1x9gknd 5153 11 male male NN cord-010119-t1x9gknd 5153 12 , , , cord-010119-t1x9gknd 5153 13 96 96 CD cord-010119-t1x9gknd 5153 14 % % NN cord-010119-t1x9gknd 5153 15 Caucasian Caucasian NNP cord-010119-t1x9gknd 5153 16 . . . cord-010119-t1x9gknd 5154 1 The the DT cord-010119-t1x9gknd 5154 2 majority majority NN cord-010119-t1x9gknd 5154 3 of of IN cord-010119-t1x9gknd 5154 4 HH HH NNP cord-010119-t1x9gknd 5154 5 donors donor NNS cord-010119-t1x9gknd 5154 6 ( ( -LRB- cord-010119-t1x9gknd 5154 7 276 276 CD cord-010119-t1x9gknd 5154 8 of of IN cord-010119-t1x9gknd 5154 9 an an DT cord-010119-t1x9gknd 5154 10 active active JJ cord-010119-t1x9gknd 5154 11 cohort cohort NN cord-010119-t1x9gknd 5154 12 of of IN cord-010119-t1x9gknd 5154 13 318 318 CD cord-010119-t1x9gknd 5154 14 ) ) -RRB- cord-010119-t1x9gknd 5154 15 are be VBP cord-010119-t1x9gknd 5154 16 in in IN cord-010119-t1x9gknd 5154 17 the the DT cord-010119-t1x9gknd 5154 18 maintenance maintenance NN cord-010119-t1x9gknd 5154 19 phase phase NN cord-010119-t1x9gknd 5154 20 of of IN cord-010119-t1x9gknd 5154 21 therapy therapy NN cord-010119-t1x9gknd 5154 22 with with IN cord-010119-t1x9gknd 5154 23 an an DT cord-010119-t1x9gknd 5154 24 average average NN cord-010119-t1x9gknd 5154 25 of of IN cord-010119-t1x9gknd 5154 26 2.6 2.6 CD cord-010119-t1x9gknd 5154 27 donations donation NNS cord-010119-t1x9gknd 5154 28 / / SYM cord-010119-t1x9gknd 5154 29 year year NN cord-010119-t1x9gknd 5154 30 and and CC cord-010119-t1x9gknd 5154 31 a a DT cord-010119-t1x9gknd 5154 32 4 4 CD cord-010119-t1x9gknd 5154 33 % % NN cord-010119-t1x9gknd 5154 34 deferral deferral NN cord-010119-t1x9gknd 5154 35 rate rate NN cord-010119-t1x9gknd 5154 36 . . . cord-010119-t1x9gknd 5155 1 Over over IN cord-010119-t1x9gknd 5155 2 the the DT cord-010119-t1x9gknd 5155 3 last last JJ cord-010119-t1x9gknd 5155 4 5 5 CD cord-010119-t1x9gknd 5155 5 years year NNS cord-010119-t1x9gknd 5155 6 , , , cord-010119-t1x9gknd 5155 7 HH HH NNP cord-010119-t1x9gknd 5155 8 donors donor NNS cord-010119-t1x9gknd 5155 9 contributed contribute VBD cord-010119-t1x9gknd 5155 10 approximately approximately RB cord-010119-t1x9gknd 5155 11 8 8 CD cord-010119-t1x9gknd 5155 12 - - SYM cord-010119-t1x9gknd 5155 13 11 11 CD cord-010119-t1x9gknd 5155 14 % % NN cord-010119-t1x9gknd 5155 15 of of IN cord-010119-t1x9gknd 5155 16 the the DT cord-010119-t1x9gknd 5155 17 hospital hospital NN cord-010119-t1x9gknd 5155 18 's 's POS cord-010119-t1x9gknd 5155 19 allogeneic allogeneic NN cord-010119-t1x9gknd 5155 20 blood blood NN cord-010119-t1x9gknd 5155 21 supply supply NN cord-010119-t1x9gknd 5155 22 , , , cord-010119-t1x9gknd 5155 23 averaging average VBG cord-010119-t1x9gknd 5155 24 475 475 CD cord-010119-t1x9gknd 5155 25 whole whole JJ cord-010119-t1x9gknd 5155 26 blood blood NN cord-010119-t1x9gknd 5155 27 units unit NNS cord-010119-t1x9gknd 5155 28 for for IN cord-010119-t1x9gknd 5155 29 transfusion transfusion NN cord-010119-t1x9gknd 5155 30 per per IN cord-010119-t1x9gknd 5155 31 year year NN cord-010119-t1x9gknd 5155 32 . . . cord-010119-t1x9gknd 5156 1 Moreover moreover RB cord-010119-t1x9gknd 5156 2 , , , cord-010119-t1x9gknd 5156 3 HH HH NNP cord-010119-t1x9gknd 5156 4 donor donor NN cord-010119-t1x9gknd 5156 5 's 's POS cord-010119-t1x9gknd 5156 6 whole whole JJ cord-010119-t1x9gknd 5156 7 blood blood NN cord-010119-t1x9gknd 5156 8 ( ( -LRB- cord-010119-t1x9gknd 5156 9 WB WB NNP cord-010119-t1x9gknd 5156 10 ) ) -RRB- cord-010119-t1x9gknd 5156 11 donations donation NNS cord-010119-t1x9gknd 5156 12 provided provide VBD cord-010119-t1x9gknd 5156 13 30 30 CD cord-010119-t1x9gknd 5156 14 - - SYM cord-010119-t1x9gknd 5156 15 40 40 CD cord-010119-t1x9gknd 5156 16 % % NN cord-010119-t1x9gknd 5156 17 of of IN cord-010119-t1x9gknd 5156 18 blood blood NN cord-010119-t1x9gknd 5156 19 for for IN cord-010119-t1x9gknd 5156 20 in in FW cord-010119-t1x9gknd 5156 21 vitro vitro FW cord-010119-t1x9gknd 5156 22 research research NN cord-010119-t1x9gknd 5156 23 at at IN cord-010119-t1x9gknd 5156 24 our -PRON- PRP$ cord-010119-t1x9gknd 5156 25 institution institution NN cord-010119-t1x9gknd 5156 26 with with IN cord-010119-t1x9gknd 5156 27 an an DT cord-010119-t1x9gknd 5156 28 average average NN cord-010119-t1x9gknd 5156 29 of of IN cord-010119-t1x9gknd 5156 30 180 180 CD cord-010119-t1x9gknd 5156 31 WB WB NNP cord-010119-t1x9gknd 5156 32 research research NN cord-010119-t1x9gknd 5156 33 donations donation NNS cord-010119-t1x9gknd 5156 34 / / SYM cord-010119-t1x9gknd 5156 35 year year NN cord-010119-t1x9gknd 5156 36 . . . cord-010119-t1x9gknd 5157 1 There there EX cord-010119-t1x9gknd 5157 2 have have VBP cord-010119-t1x9gknd 5157 3 been be VBN cord-010119-t1x9gknd 5157 4 no no DT cord-010119-t1x9gknd 5157 5 HH HH NNP cord-010119-t1x9gknd 5157 6 donor donor NN cord-010119-t1x9gknd 5157 7 - - HYPH cord-010119-t1x9gknd 5157 8 derived derive VBN cord-010119-t1x9gknd 5157 9 transfusion transfusion NN cord-010119-t1x9gknd 5157 10 - - HYPH cord-010119-t1x9gknd 5157 11 transmitted transmit VBN cord-010119-t1x9gknd 5157 12 infections infection NNS cord-010119-t1x9gknd 5157 13 over over IN cord-010119-t1x9gknd 5157 14 16 16 CD cord-010119-t1x9gknd 5157 15 years year NNS cord-010119-t1x9gknd 5157 16 . . . cord-010119-t1x9gknd 5158 1 Since since IN cord-010119-t1x9gknd 5158 2 5/23/16 5/23/16 CD cord-010119-t1x9gknd 5158 3 , , , cord-010119-t1x9gknd 5158 4 with with IN cord-010119-t1x9gknd 5158 5 an an DT cord-010119-t1x9gknd 5158 6 increase increase NN cord-010119-t1x9gknd 5158 7 in in IN cord-010119-t1x9gknd 5158 8 male male JJ cord-010119-t1x9gknd 5158 9 Hgb Hgb NNP cord-010119-t1x9gknd 5158 10 deferral deferral NN cord-010119-t1x9gknd 5158 11 threshold threshold NN cord-010119-t1x9gknd 5158 12 to to IN cord-010119-t1x9gknd 5158 13 13g 13g NNS cord-010119-t1x9gknd 5158 14 / / SYM cord-010119-t1x9gknd 5158 15 dl dl NN cord-010119-t1x9gknd 5158 16 , , , cord-010119-t1x9gknd 5158 17 there there EX cord-010119-t1x9gknd 5158 18 has have VBZ cord-010119-t1x9gknd 5158 19 been be VBN cord-010119-t1x9gknd 5158 20 only only RB cord-010119-t1x9gknd 5158 21 1 1 CD cord-010119-t1x9gknd 5158 22 HH hh NN cord-010119-t1x9gknd 5158 23 male male NN cord-010119-t1x9gknd 5158 24 deferral deferral NN cord-010119-t1x9gknd 5158 25 from from IN cord-010119-t1x9gknd 5158 26 blood blood NN cord-010119-t1x9gknd 5158 27 donation donation NN cord-010119-t1x9gknd 5158 28 . . . cord-010119-t1x9gknd 5159 1 Conclusion conclusion NN cord-010119-t1x9gknd 5159 2 : : : cord-010119-t1x9gknd 5160 1 A a DT cord-010119-t1x9gknd 5160 2 simple simple JJ cord-010119-t1x9gknd 5160 3 , , , cord-010119-t1x9gknd 5160 4 safe safe JJ cord-010119-t1x9gknd 5160 5 system system NN cord-010119-t1x9gknd 5160 6 for for IN cord-010119-t1x9gknd 5160 7 donor donor NN cord-010119-t1x9gknd 5160 8 evaluation evaluation NN cord-010119-t1x9gknd 5160 9 , , , cord-010119-t1x9gknd 5160 10 phlebotomy phlebotomy NN cord-010119-t1x9gknd 5160 11 management management NN cord-010119-t1x9gknd 5160 12 , , , cord-010119-t1x9gknd 5160 13 and and CC cord-010119-t1x9gknd 5160 14 transfusion transfusion NN cord-010119-t1x9gknd 5160 15 of of IN cord-010119-t1x9gknd 5160 16 blood blood NN cord-010119-t1x9gknd 5160 17 drawn draw VBN cord-010119-t1x9gknd 5160 18 from from IN cord-010119-t1x9gknd 5160 19 HH HH NNP cord-010119-t1x9gknd 5160 20 subjects subject NNS cord-010119-t1x9gknd 5160 21 was be VBD cord-010119-t1x9gknd 5160 22 established establish VBN cord-010119-t1x9gknd 5160 23 . . . cord-010119-t1x9gknd 5161 1 Blood blood NN cord-010119-t1x9gknd 5161 2 donated donate VBN cord-010119-t1x9gknd 5161 3 by by IN cord-010119-t1x9gknd 5161 4 HH HH NNP cord-010119-t1x9gknd 5161 5 donors donor NNS cord-010119-t1x9gknd 5161 6 remains remain VBZ cord-010119-t1x9gknd 5161 7 an an DT cord-010119-t1x9gknd 5161 8 important important JJ cord-010119-t1x9gknd 5161 9 resource resource NN cord-010119-t1x9gknd 5161 10 at at IN cord-010119-t1x9gknd 5161 11 our -PRON- PRP$ cord-010119-t1x9gknd 5161 12 hospital hospital NN cord-010119-t1x9gknd 5161 13 . . . cord-010119-t1x9gknd 5162 1 HH HH NNP cord-010119-t1x9gknd 5162 2 donors donor NNS cord-010119-t1x9gknd 5162 3 benefit benefit VBP cord-010119-t1x9gknd 5162 4 from from IN cord-010119-t1x9gknd 5162 5 careful careful JJ cord-010119-t1x9gknd 5162 6 medical medical JJ cord-010119-t1x9gknd 5162 7 follow follow NN cord-010119-t1x9gknd 5162 8 - - HYPH cord-010119-t1x9gknd 5162 9 up up NN cord-010119-t1x9gknd 5162 10 of of IN cord-010119-t1x9gknd 5162 11 their -PRON- PRP$ cord-010119-t1x9gknd 5162 12 iron iron NN cord-010119-t1x9gknd 5162 13 status status NN cord-010119-t1x9gknd 5162 14 . . . cord-010119-t1x9gknd 5163 1 This this DT cord-010119-t1x9gknd 5163 2 mutually mutually RB cord-010119-t1x9gknd 5163 3 beneficial beneficial JJ cord-010119-t1x9gknd 5163 4 relationship relationship NN cord-010119-t1x9gknd 5163 5 is be VBZ cord-010119-t1x9gknd 5163 6 feasible feasible JJ cord-010119-t1x9gknd 5163 7 and and CC cord-010119-t1x9gknd 5163 8 sustainable sustainable JJ cord-010119-t1x9gknd 5163 9 . . . cord-010119-t1x9gknd 5164 1 Testing test VBG cord-010119-t1x9gknd 5164 2 for for IN cord-010119-t1x9gknd 5164 3 Accuracy accuracy NN cord-010119-t1x9gknd 5164 4 of of IN cord-010119-t1x9gknd 5164 5 Non non JJ cord-010119-t1x9gknd 5164 6 - - JJ cord-010119-t1x9gknd 5164 7 Invasive invasive JJ cord-010119-t1x9gknd 5164 8 Blood blood NN cord-010119-t1x9gknd 5164 9 Hemoglobin Hemoglobin NNP cord-010119-t1x9gknd 5164 10 Methodology Methodology NNP cord-010119-t1x9gknd 5164 11 in in IN cord-010119-t1x9gknd 5164 12 a a DT cord-010119-t1x9gknd 5164 13 Blood Blood NNP cord-010119-t1x9gknd 5164 14 Donor Donor NNP cord-010119-t1x9gknd 5164 15 Setting set VBG cord-010119-t1x9gknd 5164 16 Michele Michele NNP cord-010119-t1x9gknd 5164 17 Walker Walker NNP cord-010119-t1x9gknd 5165 1 * * NFP cord-010119-t1x9gknd 5165 2 , , , cord-010119-t1x9gknd 5165 3 Sharon Sharon NNP cord-010119-t1x9gknd 5165 4 Garcia Garcia NNP cord-010119-t1x9gknd 5165 5 and and CC cord-010119-t1x9gknd 5165 6 Mythili Mythili NNP cord-010119-t1x9gknd 5165 7 Ram Ram NNP cord-010119-t1x9gknd 5165 8 . . . cord-010119-t1x9gknd 5166 1 Gulf Gulf NNP cord-010119-t1x9gknd 5166 2 Coast Coast NNP cord-010119-t1x9gknd 5166 3 Regional Regional NNP cord-010119-t1x9gknd 5166 4 Blood Blood NNP cord-010119-t1x9gknd 5166 5 Center Center NNP cord-010119-t1x9gknd 5166 6 Background Background NNP cord-010119-t1x9gknd 5166 7 / / SYM cord-010119-t1x9gknd 5166 8 Case Case NNP cord-010119-t1x9gknd 5166 9 Studies Studies NNPS cord-010119-t1x9gknd 5166 10 : : : cord-010119-t1x9gknd 5166 11 The the DT cord-010119-t1x9gknd 5166 12 objective objective NN cord-010119-t1x9gknd 5166 13 of of IN cord-010119-t1x9gknd 5166 14 the the DT cord-010119-t1x9gknd 5166 15 study study NN cord-010119-t1x9gknd 5166 16 was be VBD cord-010119-t1x9gknd 5166 17 to to TO cord-010119-t1x9gknd 5166 18 assess assess VB cord-010119-t1x9gknd 5166 19 the the DT cord-010119-t1x9gknd 5166 20 accuracy accuracy NN cord-010119-t1x9gknd 5166 21 of of IN cord-010119-t1x9gknd 5166 22 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5166 23 ( ( -LRB- cord-010119-t1x9gknd 5166 24 Hb Hb NNP cord-010119-t1x9gknd 5166 25 ) ) -RRB- cord-010119-t1x9gknd 5166 26 levels level NNS cord-010119-t1x9gknd 5166 27 measured measure VBN cord-010119-t1x9gknd 5166 28 on on IN cord-010119-t1x9gknd 5166 29 the the DT cord-010119-t1x9gknd 5166 30 OrSense OrSense NNP cord-010119-t1x9gknd 5166 31 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5166 32 non non JJ cord-010119-t1x9gknd 5166 33 - - JJ cord-010119-t1x9gknd 5166 34 invasive invasive JJ cord-010119-t1x9gknd 5166 35 occlusion occlusion NN cord-010119-t1x9gknd 5166 36 spectroscopy spectroscopy NN cord-010119-t1x9gknd 5166 37 device device NN cord-010119-t1x9gknd 5166 38 by by IN cord-010119-t1x9gknd 5166 39 comparing compare VBG cord-010119-t1x9gknd 5166 40 them -PRON- PRP cord-010119-t1x9gknd 5166 41 to to IN cord-010119-t1x9gknd 5166 42 Hb Hb NNP cord-010119-t1x9gknd 5166 43 levels level NNS cord-010119-t1x9gknd 5166 44 measured measure VBN cord-010119-t1x9gknd 5166 45 on on IN cord-010119-t1x9gknd 5166 46 venous venous JJ cord-010119-t1x9gknd 5166 47 samples sample NNS cord-010119-t1x9gknd 5166 48 with with IN cord-010119-t1x9gknd 5166 49 a a DT cord-010119-t1x9gknd 5166 50 laboratory laboratory NN cord-010119-t1x9gknd 5166 51 hematology hematology NN cord-010119-t1x9gknd 5166 52 analyzer analyzer NN cord-010119-t1x9gknd 5166 53 . . . cord-010119-t1x9gknd 5167 1 In in IN cord-010119-t1x9gknd 5167 2 addition addition NN cord-010119-t1x9gknd 5167 3 , , , cord-010119-t1x9gknd 5167 4 the the DT cord-010119-t1x9gknd 5167 5 study study NN cord-010119-t1x9gknd 5167 6 examined examine VBD cord-010119-t1x9gknd 5167 7 operator operator NN cord-010119-t1x9gknd 5167 8 ease ease NN cord-010119-t1x9gknd 5167 9 of of IN cord-010119-t1x9gknd 5167 10 use use NN cord-010119-t1x9gknd 5167 11 and and CC cord-010119-t1x9gknd 5167 12 donor donor NN cord-010119-t1x9gknd 5167 13 satisfaction satisfaction NN cord-010119-t1x9gknd 5167 14 with with IN cord-010119-t1x9gknd 5167 15 a a DT cord-010119-t1x9gknd 5167 16 finger finger NN cord-010119-t1x9gknd 5167 17 stick stick NN cord-010119-t1x9gknd 5167 18 - - HYPH cord-010119-t1x9gknd 5167 19 free free JJ cord-010119-t1x9gknd 5167 20 method method NN cord-010119-t1x9gknd 5167 21 . . . cord-010119-t1x9gknd 5168 1 Study Study NNP cord-010119-t1x9gknd 5168 2 Design Design NNP cord-010119-t1x9gknd 5168 3 / / SYM cord-010119-t1x9gknd 5168 4 Method method NN cord-010119-t1x9gknd 5168 5 : : : cord-010119-t1x9gknd 5168 6 Study study NN cord-010119-t1x9gknd 5168 7 procedures procedure NNS cord-010119-t1x9gknd 5168 8 and and CC cord-010119-t1x9gknd 5168 9 protocol protocol NN cord-010119-t1x9gknd 5168 10 , , , cord-010119-t1x9gknd 5168 11 including include VBG cord-010119-t1x9gknd 5168 12 acceptance acceptance NN cord-010119-t1x9gknd 5168 13 criteria criterion NNS cord-010119-t1x9gknd 5168 14 , , , cord-010119-t1x9gknd 5168 15 were be VBD cord-010119-t1x9gknd 5168 16 defined define VBN cord-010119-t1x9gknd 5168 17 in in IN cord-010119-t1x9gknd 5168 18 conjunction conjunction NN cord-010119-t1x9gknd 5168 19 with with IN cord-010119-t1x9gknd 5168 20 the the DT cord-010119-t1x9gknd 5168 21 device device NN cord-010119-t1x9gknd 5168 22 manufacturer manufacturer NN cord-010119-t1x9gknd 5168 23 to to TO cord-010119-t1x9gknd 5168 24 determine determine VB cord-010119-t1x9gknd 5168 25 the the DT cord-010119-t1x9gknd 5168 26 standard standard JJ cord-010119-t1x9gknd 5168 27 deviation deviation NN cord-010119-t1x9gknd 5168 28 ( ( -LRB- cord-010119-t1x9gknd 5168 29 SD sd NN cord-010119-t1x9gknd 5168 30 ) ) -RRB- cord-010119-t1x9gknd 5168 31 of of IN cord-010119-t1x9gknd 5168 32 the the DT cord-010119-t1x9gknd 5168 33 difference difference NN cord-010119-t1x9gknd 5168 34 between between IN cord-010119-t1x9gknd 5168 35 the the DT cord-010119-t1x9gknd 5168 36 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5168 37 non non JJ cord-010119-t1x9gknd 5168 38 - - JJ cord-010119-t1x9gknd 5168 39 invasive invasive JJ cord-010119-t1x9gknd 5168 40 sample sample NN cord-010119-t1x9gknd 5168 41 results result NNS cord-010119-t1x9gknd 5168 42 and and CC cord-010119-t1x9gknd 5168 43 the the DT cord-010119-t1x9gknd 5168 44 Sysmex Sysmex NNP cord-010119-t1x9gknd 5168 45 hematology hematology NN cord-010119-t1x9gknd 5168 46 analyzer analyzer NN cord-010119-t1x9gknd 5168 47 venous venous JJ cord-010119-t1x9gknd 5168 48 sample sample NN cord-010119-t1x9gknd 5168 49 results result NNS cord-010119-t1x9gknd 5168 50 . . . cord-010119-t1x9gknd 5169 1 Staff staff NN cord-010119-t1x9gknd 5169 2 were be VBD cord-010119-t1x9gknd 5169 3 provided provide VBN cord-010119-t1x9gknd 5169 4 training training NN cord-010119-t1x9gknd 5169 5 on on IN cord-010119-t1x9gknd 5169 6 the the DT cord-010119-t1x9gknd 5169 7 use use NN cord-010119-t1x9gknd 5169 8 of of IN cord-010119-t1x9gknd 5169 9 the the DT cord-010119-t1x9gknd 5169 10 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5169 11 non non JJ cord-010119-t1x9gknd 5169 12 - - JJ cord-010119-t1x9gknd 5169 13 invasive invasive JJ cord-010119-t1x9gknd 5169 14 occlusion occlusion NN cord-010119-t1x9gknd 5169 15 spectroscopy spectroscopy NN cord-010119-t1x9gknd 5169 16 device device NN cord-010119-t1x9gknd 5169 17 . . . cord-010119-t1x9gknd 5170 1 Over over IN cord-010119-t1x9gknd 5170 2 a a DT cord-010119-t1x9gknd 5170 3 span span NN cord-010119-t1x9gknd 5170 4 of of IN cord-010119-t1x9gknd 5170 5 7 7 CD cord-010119-t1x9gknd 5170 6 days day NNS cord-010119-t1x9gknd 5170 7 , , , cord-010119-t1x9gknd 5170 8 200 200 CD cord-010119-t1x9gknd 5170 9 eligible eligible JJ cord-010119-t1x9gknd 5170 10 blood blood NN cord-010119-t1x9gknd 5170 11 donors donor NNS cord-010119-t1x9gknd 5170 12 , , , cord-010119-t1x9gknd 5170 13 both both CC cord-010119-t1x9gknd 5170 14 male male JJ cord-010119-t1x9gknd 5170 15 and and CC cord-010119-t1x9gknd 5170 16 female female JJ cord-010119-t1x9gknd 5170 17 , , , cord-010119-t1x9gknd 5170 18 were be VBD cord-010119-t1x9gknd 5170 19 first first RB cord-010119-t1x9gknd 5170 20 screened screen VBN cord-010119-t1x9gknd 5170 21 by by IN cord-010119-t1x9gknd 5170 22 the the DT cord-010119-t1x9gknd 5170 23 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5170 24 non non JJ cord-010119-t1x9gknd 5170 25 - - JJ cord-010119-t1x9gknd 5170 26 invasive invasive JJ cord-010119-t1x9gknd 5170 27 occlusion occlusion NN cord-010119-t1x9gknd 5170 28 spectroscopy spectroscopy NN cord-010119-t1x9gknd 5170 29 device device NN cord-010119-t1x9gknd 5170 30 followed follow VBN cord-010119-t1x9gknd 5170 31 by by IN cord-010119-t1x9gknd 5170 32 performance performance NN cord-010119-t1x9gknd 5170 33 testing testing NN cord-010119-t1x9gknd 5170 34 utilizing utilize VBG cord-010119-t1x9gknd 5170 35 a a DT cord-010119-t1x9gknd 5170 36 capillary capillary JJ cord-010119-t1x9gknd 5170 37 blood blood NN cord-010119-t1x9gknd 5170 38 screening screening NN cord-010119-t1x9gknd 5170 39 method method NN cord-010119-t1x9gknd 5170 40 . . . cord-010119-t1x9gknd 5171 1 A a DT cord-010119-t1x9gknd 5171 2 venous venous JJ cord-010119-t1x9gknd 5171 3 sample sample NN cord-010119-t1x9gknd 5171 4 was be VBD cord-010119-t1x9gknd 5171 5 collected collect VBN cord-010119-t1x9gknd 5171 6 from from IN cord-010119-t1x9gknd 5171 7 each each DT cord-010119-t1x9gknd 5171 8 of of IN cord-010119-t1x9gknd 5171 9 the the DT cord-010119-t1x9gknd 5171 10 200 200 CD cord-010119-t1x9gknd 5171 11 blood blood NN cord-010119-t1x9gknd 5171 12 donors donor NNS cord-010119-t1x9gknd 5171 13 for for IN cord-010119-t1x9gknd 5171 14 the the DT cord-010119-t1x9gknd 5171 15 performance performance NN cord-010119-t1x9gknd 5171 16 of of IN cord-010119-t1x9gknd 5171 17 Hb Hb NNP cord-010119-t1x9gknd 5171 18 measurement measurement NN cord-010119-t1x9gknd 5171 19 on on IN cord-010119-t1x9gknd 5171 20 the the DT cord-010119-t1x9gknd 5171 21 Sysmex Sysmex NNP cord-010119-t1x9gknd 5171 22 hematology hematology NN cord-010119-t1x9gknd 5171 23 analyzer analyzer NN cord-010119-t1x9gknd 5171 24 within within IN cord-010119-t1x9gknd 5171 25 1 1 CD cord-010119-t1x9gknd 5171 26 - - SYM cord-010119-t1x9gknd 5171 27 3 3 CD cord-010119-t1x9gknd 5171 28 hours hour NNS cord-010119-t1x9gknd 5171 29 of of IN cord-010119-t1x9gknd 5171 30 collecting collect VBG cord-010119-t1x9gknd 5171 31 the the DT cord-010119-t1x9gknd 5171 32 venous venous JJ cord-010119-t1x9gknd 5171 33 samples sample NNS cord-010119-t1x9gknd 5171 34 . . . cord-010119-t1x9gknd 5172 1 Results/ Results/ . cord-010119-t1x9gknd 5173 1 Finding finding NN cord-010119-t1x9gknd 5173 2 : : : cord-010119-t1x9gknd 5174 1 The the DT cord-010119-t1x9gknd 5174 2 SD sd NN cord-010119-t1x9gknd 5174 3 of of IN cord-010119-t1x9gknd 5174 4 the the DT cord-010119-t1x9gknd 5174 5 difference difference NN cord-010119-t1x9gknd 5174 6 between between IN cord-010119-t1x9gknd 5174 7 the the DT cord-010119-t1x9gknd 5174 8 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5174 9 non non JJ cord-010119-t1x9gknd 5174 10 - - JJ cord-010119-t1x9gknd 5174 11 invasive invasive JJ cord-010119-t1x9gknd 5174 12 sample sample NN cord-010119-t1x9gknd 5174 13 results result NNS cord-010119-t1x9gknd 5174 14 and and CC cord-010119-t1x9gknd 5174 15 the the DT cord-010119-t1x9gknd 5174 16 Sysmex Sysmex NNP cord-010119-t1x9gknd 5174 17 hematology hematology NN cord-010119-t1x9gknd 5174 18 analyzer analyzer NN cord-010119-t1x9gknd 5174 19 venous venous JJ cord-010119-t1x9gknd 5174 20 sample sample NN cord-010119-t1x9gknd 5174 21 results result NNS cord-010119-t1x9gknd 5174 22 was be VBD cord-010119-t1x9gknd 5174 23 not not RB cord-010119-t1x9gknd 5174 24 to to TO cord-010119-t1x9gknd 5174 25 exceed exceed VB cord-010119-t1x9gknd 5174 26 1.1g 1.1g CD cord-010119-t1x9gknd 5174 27 / / SYM cord-010119-t1x9gknd 5174 28 dl dl NN cord-010119-t1x9gknd 5174 29 . . . cord-010119-t1x9gknd 5175 1 The the DT cord-010119-t1x9gknd 5175 2 Hb Hb NNP cord-010119-t1x9gknd 5175 3 measurements measurement NNS cord-010119-t1x9gknd 5175 4 obtained obtain VBN cord-010119-t1x9gknd 5175 5 from from IN cord-010119-t1x9gknd 5175 6 the the DT cord-010119-t1x9gknd 5175 7 NBM-200 nbm-200 NN cord-010119-t1x9gknd 5175 8 and and CC cord-010119-t1x9gknd 5175 9 the the DT cord-010119-t1x9gknd 5175 10 Sysmex Sysmex NNP cord-010119-t1x9gknd 5175 11 hematology hematology NN cord-010119-t1x9gknd 5175 12 analyzer analyzer NN cord-010119-t1x9gknd 5175 13 were be VBD cord-010119-t1x9gknd 5175 14 analyzed analyze VBN cord-010119-t1x9gknd 5175 15 using use VBG cord-010119-t1x9gknd 5175 16 the the DT cord-010119-t1x9gknd 5175 17 statistical statistical JJ cord-010119-t1x9gknd 5175 18 software software NN cord-010119-t1x9gknd 5175 19 Minitab Minitab NNP cord-010119-t1x9gknd 5175 20 and and CC cord-010119-t1x9gknd 5175 21 the the DT cord-010119-t1x9gknd 5175 22 SD sd NN cord-010119-t1x9gknd 5175 23 of of IN cord-010119-t1x9gknd 5175 24 the the DT cord-010119-t1x9gknd 5175 25 difference difference NN cord-010119-t1x9gknd 5175 26 was be VBD cord-010119-t1x9gknd 5175 27 reported report VBN cord-010119-t1x9gknd 5175 28 to to TO cord-010119-t1x9gknd 5175 29 be be VB cord-010119-t1x9gknd 5175 30 0.978 0.978 CD cord-010119-t1x9gknd 5175 31 g g NNP cord-010119-t1x9gknd 5175 32 / / SYM cord-010119-t1x9gknd 5175 33 dl dl NN cord-010119-t1x9gknd 5175 34 . . . cord-010119-t1x9gknd 5176 1 The the DT cord-010119-t1x9gknd 5176 2 precision precision NN cord-010119-t1x9gknd 5176 3 of of IN cord-010119-t1x9gknd 5176 4 the the DT cord-010119-t1x9gknd 5176 5 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5176 6 yielded yield VBD cord-010119-t1x9gknd 5176 7 a a DT cord-010119-t1x9gknd 5176 8 co co NN cord-010119-t1x9gknd 5176 9 - - JJ cord-010119-t1x9gknd 5176 10 efficient efficient JJ cord-010119-t1x9gknd 5176 11 of of IN cord-010119-t1x9gknd 5176 12 variation variation NN cord-010119-t1x9gknd 5176 13 of of IN cord-010119-t1x9gknd 5176 14 .02 .02 NFP cord-010119-t1x9gknd 5176 15 g g NNP cord-010119-t1x9gknd 5176 16 / / SYM cord-010119-t1x9gknd 5176 17 dl dl NN cord-010119-t1x9gknd 5176 18 and and CC cord-010119-t1x9gknd 5176 19 a a DT cord-010119-t1x9gknd 5176 20 standard standard JJ cord-010119-t1x9gknd 5176 21 deviation deviation NN cord-010119-t1x9gknd 5176 22 of of IN cord-010119-t1x9gknd 5176 23 .33 .33 CD cord-010119-t1x9gknd 5176 24 g g NN cord-010119-t1x9gknd 5176 25 / / SYM cord-010119-t1x9gknd 5176 26 dl dl NN cord-010119-t1x9gknd 5176 27 . . . cord-010119-t1x9gknd 5177 1 Conclusion conclusion NN cord-010119-t1x9gknd 5177 2 : : : cord-010119-t1x9gknd 5178 1 The the DT cord-010119-t1x9gknd 5178 2 operators operator NNS cord-010119-t1x9gknd 5178 3 found find VBD cord-010119-t1x9gknd 5178 4 the the DT cord-010119-t1x9gknd 5178 5 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5178 6 easy easy JJ cord-010119-t1x9gknd 5178 7 to to TO cord-010119-t1x9gknd 5178 8 install install VB cord-010119-t1x9gknd 5178 9 , , , cord-010119-t1x9gknd 5178 10 maintain maintain VB cord-010119-t1x9gknd 5178 11 , , , cord-010119-t1x9gknd 5178 12 and and CC cord-010119-t1x9gknd 5178 13 operate operate VB cord-010119-t1x9gknd 5178 14 with with IN cord-010119-t1x9gknd 5178 15 minimal minimal JJ cord-010119-t1x9gknd 5178 16 training training NN cord-010119-t1x9gknd 5178 17 . . . cord-010119-t1x9gknd 5179 1 The the DT cord-010119-t1x9gknd 5179 2 NBM-200 NBM-200 NNP cord-010119-t1x9gknd 5179 3 non non JJ cord-010119-t1x9gknd 5179 4 - - JJ cord-010119-t1x9gknd 5179 5 invasive invasive JJ cord-010119-t1x9gknd 5179 6 occlusion occlusion NN cord-010119-t1x9gknd 5179 7 spectroscopy spectroscopy NN cord-010119-t1x9gknd 5179 8 technology technology NN cord-010119-t1x9gknd 5179 9 showed show VBD cord-010119-t1x9gknd 5179 10 accurate accurate JJ cord-010119-t1x9gknd 5179 11 performance performance NN cord-010119-t1x9gknd 5179 12 compared compare VBN cord-010119-t1x9gknd 5179 13 with with IN cord-010119-t1x9gknd 5179 14 the the DT cord-010119-t1x9gknd 5179 15 venous venous JJ cord-010119-t1x9gknd 5179 16 sample sample NN cord-010119-t1x9gknd 5179 17 results result NNS cord-010119-t1x9gknd 5179 18 . . . cord-010119-t1x9gknd 5180 1 It -PRON- PRP cord-010119-t1x9gknd 5180 2 was be VBD cord-010119-t1x9gknd 5180 3 comparable comparable JJ cord-010119-t1x9gknd 5180 4 to to IN cord-010119-t1x9gknd 5180 5 the the DT cord-010119-t1x9gknd 5180 6 capillary capillary JJ cord-010119-t1x9gknd 5180 7 finger finger NN cord-010119-t1x9gknd 5180 8 stick stick NN cord-010119-t1x9gknd 5180 9 method method NN cord-010119-t1x9gknd 5180 10 and and CC cord-010119-t1x9gknd 5180 11 deemed deem VBD cord-010119-t1x9gknd 5180 12 suitable suitable JJ cord-010119-t1x9gknd 5180 13 for for IN cord-010119-t1x9gknd 5180 14 screening screen VBG cord-010119-t1x9gknd 5180 15 donors donor NNS cord-010119-t1x9gknd 5180 16 . . . cord-010119-t1x9gknd 5181 1 Donors donor NNS cord-010119-t1x9gknd 5181 2 were be VBD cord-010119-t1x9gknd 5181 3 satisfied satisfied JJ cord-010119-t1x9gknd 5181 4 with with IN cord-010119-t1x9gknd 5181 5 the the DT cord-010119-t1x9gknd 5181 6 process process NN cord-010119-t1x9gknd 5181 7 and and CC cord-010119-t1x9gknd 5181 8 appreciated appreciate VBD cord-010119-t1x9gknd 5181 9 the the DT cord-010119-t1x9gknd 5181 10 safe safe JJ cord-010119-t1x9gknd 5181 11 , , , cord-010119-t1x9gknd 5181 12 painless painless JJ cord-010119-t1x9gknd 5181 13 methodology methodology NN cord-010119-t1x9gknd 5181 14 . . . cord-010119-t1x9gknd 5182 1 Ronel Ronel NNP cord-010119-t1x9gknd 5182 2 Swanevelder Swanevelder NNP cord-010119-t1x9gknd 5182 3 1 1 CD cord-010119-t1x9gknd 5182 4 , , , cord-010119-t1x9gknd 5182 5 Ravi Ravi NNP cord-010119-t1x9gknd 5182 6 Reddy Reddy NNP cord-010119-t1x9gknd 5182 7 1 1 CD cord-010119-t1x9gknd 5182 8 , , , cord-010119-t1x9gknd 5182 9 Dhuly Dhuly NNP cord-010119-t1x9gknd 5182 10 Chowdhury Chowdhury NNP cord-010119-t1x9gknd 5182 11 2 2 CD cord-010119-t1x9gknd 5182 12 , , , cord-010119-t1x9gknd 5182 13 Don Don NNP cord-010119-t1x9gknd 5182 14 Brambilla Brambilla NNP cord-010119-t1x9gknd 5182 15 2 2 CD cord-010119-t1x9gknd 5182 16 and and CC cord-010119-t1x9gknd 5182 17 Edward Edward NNP cord-010119-t1x9gknd 5182 18 L. L. NNP cord-010119-t1x9gknd 5182 19 Murphy Murphy NNP cord-010119-t1x9gknd 5183 1 * * NFP cord-010119-t1x9gknd 5183 2 3 3 CD cord-010119-t1x9gknd 5183 3 . . . cord-010119-t1x9gknd 5183 4 1 1 CD cord-010119-t1x9gknd 5183 5 SANBS SANBS NNP cord-010119-t1x9gknd 5183 6 , , , cord-010119-t1x9gknd 5183 7 2 2 CD cord-010119-t1x9gknd 5183 8 RTI RTI NNP cord-010119-t1x9gknd 5183 9 International International NNP cord-010119-t1x9gknd 5183 10 , , , cord-010119-t1x9gknd 5183 11 3 3 CD cord-010119-t1x9gknd 5183 12 UCSF UCSF NNP cord-010119-t1x9gknd 5183 13 / / SYM cord-010119-t1x9gknd 5183 14 BSRI BSRI NNP cord-010119-t1x9gknd 5183 15 Background Background NNP cord-010119-t1x9gknd 5183 16 / / SYM cord-010119-t1x9gknd 5183 17 Case Case NNP cord-010119-t1x9gknd 5183 18 Studies Studies NNPS cord-010119-t1x9gknd 5183 19 : : : cord-010119-t1x9gknd 5184 1 To to TO cord-010119-t1x9gknd 5184 2 maintain maintain VB cord-010119-t1x9gknd 5184 3 an an DT cord-010119-t1x9gknd 5184 4 adequate adequate JJ cord-010119-t1x9gknd 5184 5 blood blood NN cord-010119-t1x9gknd 5184 6 supply supply NN cord-010119-t1x9gknd 5184 7 , , , cord-010119-t1x9gknd 5184 8 South south JJ cord-010119-t1x9gknd 5184 9 African african JJ cord-010119-t1x9gknd 5184 10 blood blood NN cord-010119-t1x9gknd 5184 11 centers center NNS cord-010119-t1x9gknd 5184 12 need need VBP cord-010119-t1x9gknd 5184 13 to to TO cord-010119-t1x9gknd 5184 14 collect collect VB cord-010119-t1x9gknd 5184 15 more more JJR cord-010119-t1x9gknd 5184 16 blood blood NN cord-010119-t1x9gknd 5184 17 from from IN cord-010119-t1x9gknd 5184 18 their -PRON- PRP$ cord-010119-t1x9gknd 5184 19 majority majority NN cord-010119-t1x9gknd 5184 20 Black black JJ cord-010119-t1x9gknd 5184 21 African african JJ cord-010119-t1x9gknd 5184 22 population population NN cord-010119-t1x9gknd 5184 23 . . . cord-010119-t1x9gknd 5185 1 Success success NN cord-010119-t1x9gknd 5185 2 in in IN cord-010119-t1x9gknd 5185 3 recruiting recruit VBG cord-010119-t1x9gknd 5185 4 first first JJ cord-010119-t1x9gknd 5185 5 - - HYPH cord-010119-t1x9gknd 5185 6 time time NN cord-010119-t1x9gknd 5185 7 Black black JJ cord-010119-t1x9gknd 5185 8 blood blood NN cord-010119-t1x9gknd 5185 9 donors donor NNS cord-010119-t1x9gknd 5185 10 has have VBZ cord-010119-t1x9gknd 5185 11 been be VBN cord-010119-t1x9gknd 5185 12 tempered temper VBN cord-010119-t1x9gknd 5185 13 by by IN cord-010119-t1x9gknd 5185 14 lower low JJR cord-010119-t1x9gknd 5185 15 suboptimal suboptimal JJ cord-010119-t1x9gknd 5185 16 return return NN cord-010119-t1x9gknd 5185 17 rates rate NNS cord-010119-t1x9gknd 5185 18 . . . cord-010119-t1x9gknd 5186 1 Study Study NNP cord-010119-t1x9gknd 5186 2 Design Design NNP cord-010119-t1x9gknd 5186 3 / / SYM cord-010119-t1x9gknd 5186 4 Method method NN cord-010119-t1x9gknd 5186 5 : : : cord-010119-t1x9gknd 5186 6 We -PRON- PRP cord-010119-t1x9gknd 5186 7 performed perform VBD cord-010119-t1x9gknd 5186 8 a a DT cord-010119-t1x9gknd 5186 9 prospective prospective JJ cord-010119-t1x9gknd 5186 10 cohort cohort NN cord-010119-t1x9gknd 5186 11 study study NN cord-010119-t1x9gknd 5186 12 of of IN cord-010119-t1x9gknd 5186 13 firsttime firsttime NNP cord-010119-t1x9gknd 5186 14 , , , cord-010119-t1x9gknd 5186 15 Black black JJ cord-010119-t1x9gknd 5186 16 blood blood NN cord-010119-t1x9gknd 5186 17 donors donor NNS cord-010119-t1x9gknd 5186 18 donating donate VBG cord-010119-t1x9gknd 5186 19 during during IN cord-010119-t1x9gknd 5186 20 a a DT cord-010119-t1x9gknd 5186 21 four four CD cord-010119-t1x9gknd 5186 22 - - HYPH cord-010119-t1x9gknd 5186 23 month month NN cord-010119-t1x9gknd 5186 24 period period NN cord-010119-t1x9gknd 5186 25 in in IN cord-010119-t1x9gknd 5186 26 2014 2014 CD cord-010119-t1x9gknd 5186 27 and and CC cord-010119-t1x9gknd 5186 28 followed follow VBD cord-010119-t1x9gknd 5186 29 them -PRON- PRP cord-010119-t1x9gknd 5186 30 for for IN cord-010119-t1x9gknd 5186 31 one one CD cord-010119-t1x9gknd 5186 32 year year NN cord-010119-t1x9gknd 5186 33 . . . cord-010119-t1x9gknd 5187 1 Within within IN cord-010119-t1x9gknd 5187 2 56 56 CD cord-010119-t1x9gknd 5187 3 days day NNS cord-010119-t1x9gknd 5187 4 post post NN cord-010119-t1x9gknd 5187 5 donation donation NN cord-010119-t1x9gknd 5187 6 , , , cord-010119-t1x9gknd 5187 7 a a DT cord-010119-t1x9gknd 5187 8 questionnaire questionnaire NN cord-010119-t1x9gknd 5187 9 including include VBG cord-010119-t1x9gknd 5187 10 questions question NNS cord-010119-t1x9gknd 5187 11 on on IN cord-010119-t1x9gknd 5187 12 blood blood NN cord-010119-t1x9gknd 5187 13 donation donation NN cord-010119-t1x9gknd 5187 14 motivators motivator NNS cord-010119-t1x9gknd 5187 15 and and CC cord-010119-t1x9gknd 5187 16 deterrents deterrent NNS cord-010119-t1x9gknd 5187 17 was be VBD cord-010119-t1x9gknd 5187 18 administered administer VBN cord-010119-t1x9gknd 5187 19 by by IN cord-010119-t1x9gknd 5187 20 telephone telephone NN cord-010119-t1x9gknd 5187 21 . . . cord-010119-t1x9gknd 5188 1 Questions question NNS cord-010119-t1x9gknd 5188 2 used use VBD cord-010119-t1x9gknd 5188 3 4-point 4-point CD cord-010119-t1x9gknd 5188 4 Likert Likert NNP cord-010119-t1x9gknd 5188 5 scales scale NNS cord-010119-t1x9gknd 5188 6 to to TO cord-010119-t1x9gknd 5188 7 assess assess VB cord-010119-t1x9gknd 5188 8 agreement agreement NN cord-010119-t1x9gknd 5188 9 with with IN cord-010119-t1x9gknd 5188 10 statements statement NNS cord-010119-t1x9gknd 5188 11 relating relate VBG cord-010119-t1x9gknd 5188 12 to to IN cord-010119-t1x9gknd 5188 13 domains domain NNS cord-010119-t1x9gknd 5188 14 of of IN cord-010119-t1x9gknd 5188 15 altruism altruism NN cord-010119-t1x9gknd 5188 16 , , , cord-010119-t1x9gknd 5188 17 collectivism collectivism NN cord-010119-t1x9gknd 5188 18 , , , cord-010119-t1x9gknd 5188 19 selfesteem selfesteem NN cord-010119-t1x9gknd 5188 20 and and CC cord-010119-t1x9gknd 5188 21 marketing marketing NN cord-010119-t1x9gknd 5188 22 derived derive VBN cord-010119-t1x9gknd 5188 23 from from IN cord-010119-t1x9gknd 5188 24 local local JJ cord-010119-t1x9gknd 5188 25 focus focus NN cord-010119-t1x9gknd 5188 26 groups group NNS cord-010119-t1x9gknd 5188 27 ( ( -LRB- cord-010119-t1x9gknd 5188 28 Muthivhi Muthivhi NNP cord-010119-t1x9gknd 5188 29 et et NNP cord-010119-t1x9gknd 5188 30 al al NNP cord-010119-t1x9gknd 5188 31 . . NNP cord-010119-t1x9gknd 5188 32 2015 2015 CD cord-010119-t1x9gknd 5188 33 ) ) -RRB- cord-010119-t1x9gknd 5188 34 . . . cord-010119-t1x9gknd 5189 1 Linking link VBG cord-010119-t1x9gknd 5189 2 questionnaires questionnaire NNS cord-010119-t1x9gknd 5189 3 to to IN cord-010119-t1x9gknd 5189 4 a a DT cord-010119-t1x9gknd 5189 5 blood blood NN cord-010119-t1x9gknd 5189 6 donation donation NN cord-010119-t1x9gknd 5189 7 database database NN cord-010119-t1x9gknd 5189 8 allowed allow VBD cord-010119-t1x9gknd 5189 9 logistic logistic JJ cord-010119-t1x9gknd 5189 10 regression regression NN cord-010119-t1x9gknd 5189 11 analysis analysis NN cord-010119-t1x9gknd 5189 12 to to TO cord-010119-t1x9gknd 5189 13 predict predict VB cord-010119-t1x9gknd 5189 14 return return NN cord-010119-t1x9gknd 5189 15 for for IN cord-010119-t1x9gknd 5189 16 a a DT cord-010119-t1x9gknd 5189 17 second second JJ cord-010119-t1x9gknd 5189 18 donation donation NN cord-010119-t1x9gknd 5189 19 within within IN cord-010119-t1x9gknd 5189 20 one one CD cord-010119-t1x9gknd 5189 21 year year NN cord-010119-t1x9gknd 5189 22 . . . cord-010119-t1x9gknd 5190 1 Results/ Results/ . cord-010119-t1x9gknd 5191 1 Finding find VBG cord-010119-t1x9gknd 5192 1 : : : cord-010119-t1x9gknd 5192 2 We -PRON- PRP cord-010119-t1x9gknd 5192 3 included include VBD cord-010119-t1x9gknd 5192 4 2,902 2,902 CD cord-010119-t1x9gknd 5192 5 first first JJ cord-010119-t1x9gknd 5192 6 - - HYPH cord-010119-t1x9gknd 5192 7 time time NN cord-010119-t1x9gknd 5192 8 Black black JJ cord-010119-t1x9gknd 5192 9 donors donor NNS cord-010119-t1x9gknd 5192 10 with with IN cord-010119-t1x9gknd 5192 11 median median JJ cord-010119-t1x9gknd 5192 12 age age NN cord-010119-t1x9gknd 5192 13 23 23 CD cord-010119-t1x9gknd 5192 14 and and CC cord-010119-t1x9gknd 5192 15 female female JJ cord-010119-t1x9gknd 5192 16 predominance predominance NN cord-010119-t1x9gknd 5192 17 ( ( -LRB- cord-010119-t1x9gknd 5192 18 59 59 CD cord-010119-t1x9gknd 5192 19 % % NN cord-010119-t1x9gknd 5192 20 ) ) -RRB- cord-010119-t1x9gknd 5192 21 . . . cord-010119-t1x9gknd 5193 1 Within within IN cord-010119-t1x9gknd 5193 2 one one CD cord-010119-t1x9gknd 5193 3 year year NN cord-010119-t1x9gknd 5193 4 , , , cord-010119-t1x9gknd 5193 5 1,786 1,786 CD cord-010119-t1x9gknd 5193 6 donors donor NNS cord-010119-t1x9gknd 5193 7 ( ( -LRB- cord-010119-t1x9gknd 5193 8 62 62 CD cord-010119-t1x9gknd 5193 9 % % NN cord-010119-t1x9gknd 5193 10 ) ) -RRB- cord-010119-t1x9gknd 5193 11 attempted attempt VBD cord-010119-t1x9gknd 5193 12 at at IN cord-010119-t1x9gknd 5193 13 least least RBS cord-010119-t1x9gknd 5193 14 one one CD cord-010119-t1x9gknd 5193 15 additional additional JJ cord-010119-t1x9gknd 5193 16 donation donation NN cord-010119-t1x9gknd 5193 17 . . . cord-010119-t1x9gknd 5194 1 When when WRB cord-010119-t1x9gknd 5194 2 Likert Likert NNP cord-010119-t1x9gknd 5194 3 scales scale NNS cord-010119-t1x9gknd 5194 4 were be VBD cord-010119-t1x9gknd 5194 5 analyzed analyze VBN cord-010119-t1x9gknd 5194 6 as as IN cord-010119-t1x9gknd 5194 7 an an DT cord-010119-t1x9gknd 5194 8 ordinal ordinal JJ cord-010119-t1x9gknd 5194 9 variable variable NN cord-010119-t1x9gknd 5194 10 ( ( -LRB- cord-010119-t1x9gknd 5194 11 45 45 CD cord-010119-t1x9gknd 5194 12 strongly strongly RB cord-010119-t1x9gknd 5194 13 agree agree VBP cord-010119-t1x9gknd 5194 14 to to IN cord-010119-t1x9gknd 5194 15 15 15 CD cord-010119-t1x9gknd 5194 16 strongly strongly RB cord-010119-t1x9gknd 5194 17 disagree disagree VB cord-010119-t1x9gknd 5194 18 ) ) -RRB- cord-010119-t1x9gknd 5194 19 , , , cord-010119-t1x9gknd 5194 20 donor donor NN cord-010119-t1x9gknd 5194 21 return return NN cord-010119-t1x9gknd 5194 22 was be VBD cord-010119-t1x9gknd 5194 23 associated associate VBN cord-010119-t1x9gknd 5194 24 with with IN cord-010119-t1x9gknd 5194 25 the the DT cord-010119-t1x9gknd 5194 26 following follow VBG cord-010119-t1x9gknd 5194 27 motivators motivator NNS cord-010119-t1x9gknd 5194 28 " " '' cord-010119-t1x9gknd 5195 1 Blood blood NN cord-010119-t1x9gknd 5195 2 donation donation NN cord-010119-t1x9gknd 5195 3 is be VBZ cord-010119-t1x9gknd 5195 4 an an DT cord-010119-t1x9gknd 5195 5 easy easy JJ cord-010119-t1x9gknd 5195 6 way way NN cord-010119-t1x9gknd 5195 7 to to TO cord-010119-t1x9gknd 5195 8 make make VB cord-010119-t1x9gknd 5195 9 a a DT cord-010119-t1x9gknd 5195 10 difference difference NN cord-010119-t1x9gknd 5195 11 " " '' cord-010119-t1x9gknd 5195 12 ( ( -LRB- cord-010119-t1x9gknd 5195 13 odds odd NNS cord-010119-t1x9gknd 5195 14 ratio ratio NN cord-010119-t1x9gknd 5195 15 for for IN cord-010119-t1x9gknd 5195 16 each each DT cord-010119-t1x9gknd 5195 17 Likert Likert NNP cord-010119-t1x9gknd 5195 18 increment increment NN cord-010119-t1x9gknd 5195 19 ( ( -LRB- cord-010119-t1x9gknd 5195 20 OR or NN cord-010119-t1x9gknd 5195 21 ) ) -RRB- cord-010119-t1x9gknd 5195 22 5 5 CD cord-010119-t1x9gknd 5195 23 1.16 1.16 CD cord-010119-t1x9gknd 5195 24 , , , cord-010119-t1x9gknd 5195 25 95 95 CD cord-010119-t1x9gknd 5195 26 % % NN cord-010119-t1x9gknd 5195 27 CI CI NNP cord-010119-t1x9gknd 5195 28 1.06 1.06 CD cord-010119-t1x9gknd 5195 29 - - HYPH cord-010119-t1x9gknd 5195 30 1.28 1.28 CD cord-010119-t1x9gknd 5195 31 ) ) -RRB- cord-010119-t1x9gknd 5195 32 , , , cord-010119-t1x9gknd 5195 33 " " `` cord-010119-t1x9gknd 5195 34 I -PRON- PRP cord-010119-t1x9gknd 5195 35 donated donate VBD cord-010119-t1x9gknd 5195 36 in in IN cord-010119-t1x9gknd 5195 37 response response NN cord-010119-t1x9gknd 5195 38 to to IN cord-010119-t1x9gknd 5195 39 adverts advert NNS cord-010119-t1x9gknd 5195 40 / / SYM cord-010119-t1x9gknd 5195 41 campaigns campaign NNS cord-010119-t1x9gknd 5195 42 on on IN cord-010119-t1x9gknd 5195 43 the the DT cord-010119-t1x9gknd 5195 44 radio radio NN cord-010119-t1x9gknd 5195 45 , , , cord-010119-t1x9gknd 5195 46 TV tv NN cord-010119-t1x9gknd 5195 47 or or CC cord-010119-t1x9gknd 5195 48 newspapers newspaper NNS cord-010119-t1x9gknd 5195 49 " " '' cord-010119-t1x9gknd 5195 50 ( ( -LRB- cord-010119-t1x9gknd 5195 51 OR51.11 OR51.11 NNP cord-010119-t1x9gknd 5195 52 , , , cord-010119-t1x9gknd 5195 53 95 95 CD cord-010119-t1x9gknd 5195 54 % % NN cord-010119-t1x9gknd 5195 55 CI CI NNP cord-010119-t1x9gknd 5195 56 1.00 1.00 CD cord-010119-t1x9gknd 5195 57 - - HYPH cord-010119-t1x9gknd 5195 58 1.23 1.23 CD cord-010119-t1x9gknd 5195 59 ) ) -RRB- cord-010119-t1x9gknd 5195 60 . . . cord-010119-t1x9gknd 5196 1 Responses response NNS cord-010119-t1x9gknd 5196 2 to to IN cord-010119-t1x9gknd 5196 3 altruism altruism NN cord-010119-t1x9gknd 5196 4 - - HYPH cord-010119-t1x9gknd 5196 5 associated associate VBN cord-010119-t1x9gknd 5196 6 statements statement NNS cord-010119-t1x9gknd 5196 7 were be VBD cord-010119-t1x9gknd 5196 8 not not RB cord-010119-t1x9gknd 5196 9 associated associate VBN cord-010119-t1x9gknd 5196 10 with with IN cord-010119-t1x9gknd 5196 11 return return NN cord-010119-t1x9gknd 5196 12 . . . cord-010119-t1x9gknd 5197 1 Among among IN cord-010119-t1x9gknd 5197 2 deterrents deterrent NNS cord-010119-t1x9gknd 5197 3 , , , cord-010119-t1x9gknd 5197 4 donors donor NNS cord-010119-t1x9gknd 5197 5 were be VBD cord-010119-t1x9gknd 5197 6 less less RBR cord-010119-t1x9gknd 5197 7 likely likely JJ cord-010119-t1x9gknd 5197 8 to to TO cord-010119-t1x9gknd 5197 9 donate donate VB cord-010119-t1x9gknd 5197 10 if if IN cord-010119-t1x9gknd 5197 11 they -PRON- PRP cord-010119-t1x9gknd 5197 12 agreed agree VBD cord-010119-t1x9gknd 5197 13 with with IN cord-010119-t1x9gknd 5197 14 the the DT cord-010119-t1x9gknd 5197 15 statement statement NN cord-010119-t1x9gknd 5197 16 " " `` cord-010119-t1x9gknd 5197 17 I -PRON- PRP cord-010119-t1x9gknd 5197 18 am be VBP cord-010119-t1x9gknd 5197 19 afraid afraid JJ cord-010119-t1x9gknd 5197 20 of of IN cord-010119-t1x9gknd 5197 21 the the DT cord-010119-t1x9gknd 5197 22 sight sight NN cord-010119-t1x9gknd 5197 23 of of IN cord-010119-t1x9gknd 5197 24 blood blood NN cord-010119-t1x9gknd 5197 25 " " '' cord-010119-t1x9gknd 5197 26 ( ( -LRB- cord-010119-t1x9gknd 5197 27 OR50.83 OR50.83 NNP cord-010119-t1x9gknd 5197 28 , , , cord-010119-t1x9gknd 5197 29 95 95 CD cord-010119-t1x9gknd 5197 30 % % NN cord-010119-t1x9gknd 5197 31 CI CI NNP cord-010119-t1x9gknd 5197 32 0.72 0.72 CD cord-010119-t1x9gknd 5197 33 - - HYPH cord-010119-t1x9gknd 5197 34 0.96 0.96 CD cord-010119-t1x9gknd 5197 35 ) ) -RRB- cord-010119-t1x9gknd 5197 36 and and CC cord-010119-t1x9gknd 5197 37 " " `` cord-010119-t1x9gknd 5197 38 I -PRON- PRP cord-010119-t1x9gknd 5197 39 was be VBD cord-010119-t1x9gknd 5197 40 n't not RB cord-010119-t1x9gknd 5197 41 treated treat VBN cord-010119-t1x9gknd 5197 42 well well RB cord-010119-t1x9gknd 5197 43 by by IN cord-010119-t1x9gknd 5197 44 the the DT cord-010119-t1x9gknd 5197 45 < < NNP cord-010119-t1x9gknd 5197 46 blood blood NNP cord-010119-t1x9gknd 5197 47 center center NNP cord-010119-t1x9gknd 5197 48 > > NFP cord-010119-t1x9gknd 5197 49 staff staff NN cord-010119-t1x9gknd 5197 50 " " '' cord-010119-t1x9gknd 5197 51 ( ( -LRB- cord-010119-t1x9gknd 5197 52 OR50.85 OR50.85 NNP cord-010119-t1x9gknd 5197 53 , , , cord-010119-t1x9gknd 5198 1 95 95 CD cord-010119-t1x9gknd 5198 2 % % NN cord-010119-t1x9gknd 5198 3 CI CI NNP cord-010119-t1x9gknd 5198 4 0.74 0.74 CD cord-010119-t1x9gknd 5198 5 - - HYPH cord-010119-t1x9gknd 5198 6 0.97 0.97 CD cord-010119-t1x9gknd 5198 7 ) ) -RRB- cord-010119-t1x9gknd 5198 8 . . . cord-010119-t1x9gknd 5199 1 Surprisingly surprisingly RB cord-010119-t1x9gknd 5199 2 , , , cord-010119-t1x9gknd 5199 3 donors donor NNS cord-010119-t1x9gknd 5199 4 were be VBD cord-010119-t1x9gknd 5199 5 more more RBR cord-010119-t1x9gknd 5199 6 likely likely JJ cord-010119-t1x9gknd 5199 7 to to TO cord-010119-t1x9gknd 5199 8 return return VB cord-010119-t1x9gknd 5199 9 if if IN cord-010119-t1x9gknd 5199 10 they -PRON- PRP cord-010119-t1x9gknd 5199 11 agreed agree VBD cord-010119-t1x9gknd 5199 12 with with IN cord-010119-t1x9gknd 5199 13 the the DT cord-010119-t1x9gknd 5199 14 statement statement NN cord-010119-t1x9gknd 5199 15 " " `` cord-010119-t1x9gknd 5199 16 I -PRON- PRP cord-010119-t1x9gknd 5199 17 was be VBD cord-010119-t1x9gknd 5199 18 afraid afraid JJ cord-010119-t1x9gknd 5199 19 of of IN cord-010119-t1x9gknd 5199 20 finding find VBG cord-010119-t1x9gknd 5199 21 out out RP cord-010119-t1x9gknd 5199 22 about about IN cord-010119-t1x9gknd 5199 23 my -PRON- PRP$ cord-010119-t1x9gknd 5199 24 HIV HIV NNP cord-010119-t1x9gknd 5199 25 status status NN cord-010119-t1x9gknd 5199 26 " " '' cord-010119-t1x9gknd 5199 27 ( ( -LRB- cord-010119-t1x9gknd 5199 28 OR51.19 OR51.19 NNP cord-010119-t1x9gknd 5199 29 , , , cord-010119-t1x9gknd 5199 30 95 95 CD cord-010119-t1x9gknd 5199 31 % % NN cord-010119-t1x9gknd 5199 32 CI CI NNP cord-010119-t1x9gknd 5199 33 1.03 1.03 CD cord-010119-t1x9gknd 5199 34 - - SYM cord-010119-t1x9gknd 5199 35 1.37 1.37 CD cord-010119-t1x9gknd 5199 36 ) ) -RRB- cord-010119-t1x9gknd 5199 37 . . . cord-010119-t1x9gknd 5200 1 A a DT cord-010119-t1x9gknd 5200 2 secondary secondary JJ cord-010119-t1x9gknd 5200 3 analysis analysis NN cord-010119-t1x9gknd 5200 4 treating treat VBG cord-010119-t1x9gknd 5200 5 the the DT cord-010119-t1x9gknd 5200 6 Likert Likert NNP cord-010119-t1x9gknd 5200 7 scales scale NNS cord-010119-t1x9gknd 5200 8 as as IN cord-010119-t1x9gknd 5200 9 4-level 4-level CD cord-010119-t1x9gknd 5200 10 categorical categorical JJ cord-010119-t1x9gknd 5200 11 variables variable NNS cord-010119-t1x9gknd 5200 12 revealed reveal VBN cord-010119-t1x9gknd 5200 13 generally generally RB cord-010119-t1x9gknd 5200 14 similar similar JJ cord-010119-t1x9gknd 5200 15 results result NNS cord-010119-t1x9gknd 5200 16 , , , cord-010119-t1x9gknd 5200 17 with with IN cord-010119-t1x9gknd 5200 18 the the DT cord-010119-t1x9gknd 5200 19 additional additional JJ cord-010119-t1x9gknd 5200 20 finding finding NN cord-010119-t1x9gknd 5200 21 that that IN cord-010119-t1x9gknd 5200 22 donors donor NNS cord-010119-t1x9gknd 5200 23 who who WP cord-010119-t1x9gknd 5200 24 disagreed disagree VBD cord-010119-t1x9gknd 5200 25 with with IN cord-010119-t1x9gknd 5200 26 the the DT cord-010119-t1x9gknd 5200 27 statements statement NNS cord-010119-t1x9gknd 5200 28 " " `` cord-010119-t1x9gknd 5200 29 If if IN cord-010119-t1x9gknd 5200 30 I -PRON- PRP cord-010119-t1x9gknd 5200 31 give give VBP cord-010119-t1x9gknd 5200 32 blood blood NN cord-010119-t1x9gknd 5200 33 then then RB cord-010119-t1x9gknd 5200 34 blood blood NN cord-010119-t1x9gknd 5200 35 will will MD cord-010119-t1x9gknd 5200 36 be be VB cord-010119-t1x9gknd 5200 37 available available JJ cord-010119-t1x9gknd 5200 38 when when WRB cord-010119-t1x9gknd 5200 39 I -PRON- PRP cord-010119-t1x9gknd 5200 40 need need VBP cord-010119-t1x9gknd 5200 41 it -PRON- PRP cord-010119-t1x9gknd 5200 42 " " '' cord-010119-t1x9gknd 5200 43 and and CC cord-010119-t1x9gknd 5200 44 " " `` cord-010119-t1x9gknd 5200 45 I -PRON- PRP cord-010119-t1x9gknd 5200 46 do do VBP cord-010119-t1x9gknd 5200 47 n't not RB cord-010119-t1x9gknd 5200 48 know know VB cord-010119-t1x9gknd 5200 49 where where WRB cord-010119-t1x9gknd 5200 50 the the DT cord-010119-t1x9gknd 5200 51 nearest near JJS cord-010119-t1x9gknd 5200 52 blood blood NN cord-010119-t1x9gknd 5200 53 collection collection NN cord-010119-t1x9gknd 5200 54 point point NN cord-010119-t1x9gknd 5200 55 is be VBZ cord-010119-t1x9gknd 5200 56 " " `` cord-010119-t1x9gknd 5200 57 were be VBD cord-010119-t1x9gknd 5200 58 more more RBR cord-010119-t1x9gknd 5200 59 likely likely JJ cord-010119-t1x9gknd 5200 60 to to TO cord-010119-t1x9gknd 5200 61 return return VB cord-010119-t1x9gknd 5200 62 . . . cord-010119-t1x9gknd 5201 1 Conclusion conclusion NN cord-010119-t1x9gknd 5201 2 : : : cord-010119-t1x9gknd 5202 1 This this DT cord-010119-t1x9gknd 5202 2 novel novel JJ cord-010119-t1x9gknd 5202 3 design design NN cord-010119-t1x9gknd 5202 4 allowed allow VBD cord-010119-t1x9gknd 5202 5 us -PRON- PRP cord-010119-t1x9gknd 5202 6 to to TO cord-010119-t1x9gknd 5202 7 study study VB cord-010119-t1x9gknd 5202 8 the the DT cord-010119-t1x9gknd 5202 9 link link NN cord-010119-t1x9gknd 5202 10 between between IN cord-010119-t1x9gknd 5202 11 donation donation NN cord-010119-t1x9gknd 5202 12 motivators motivator NNS cord-010119-t1x9gknd 5202 13 and and CC cord-010119-t1x9gknd 5202 14 deterrents deterrent NNS cord-010119-t1x9gknd 5202 15 and and CC cord-010119-t1x9gknd 5202 16 actual actual JJ cord-010119-t1x9gknd 5202 17 rather rather RB cord-010119-t1x9gknd 5202 18 than than IN cord-010119-t1x9gknd 5202 19 intended intend VBN cord-010119-t1x9gknd 5202 20 return return NN cord-010119-t1x9gknd 5202 21 for for IN cord-010119-t1x9gknd 5202 22 donation donation NN cord-010119-t1x9gknd 5202 23 . . . cord-010119-t1x9gknd 5203 1 It -PRON- PRP cord-010119-t1x9gknd 5203 2 is be VBZ cord-010119-t1x9gknd 5203 3 interesting interesting JJ cord-010119-t1x9gknd 5203 4 that that IN cord-010119-t1x9gknd 5203 5 self self NN cord-010119-t1x9gknd 5203 6 - - HYPH cord-010119-t1x9gknd 5203 7 esteem esteem NN cord-010119-t1x9gknd 5203 8 and and CC cord-010119-t1x9gknd 5203 9 marketing marketing NN cord-010119-t1x9gknd 5203 10 predicted predict VBN cord-010119-t1x9gknd 5203 11 return return NN cord-010119-t1x9gknd 5203 12 better well RBR cord-010119-t1x9gknd 5203 13 than than IN cord-010119-t1x9gknd 5203 14 altruism altruism NN cord-010119-t1x9gknd 5203 15 . . . cord-010119-t1x9gknd 5204 1 Fear fear NN cord-010119-t1x9gknd 5204 2 and and CC cord-010119-t1x9gknd 5204 3 poor poor JJ cord-010119-t1x9gknd 5204 4 customer customer NN cord-010119-t1x9gknd 5204 5 experience experience NN cord-010119-t1x9gknd 5204 6 are be VBP cord-010119-t1x9gknd 5204 7 recognized recognize VBN cord-010119-t1x9gknd 5204 8 deterrents deterrent NNS cord-010119-t1x9gknd 5204 9 which which WDT cord-010119-t1x9gknd 5204 10 could could MD cord-010119-t1x9gknd 5204 11 be be VB cord-010119-t1x9gknd 5204 12 addressed address VBN cord-010119-t1x9gknd 5204 13 . . . cord-010119-t1x9gknd 5205 1 We -PRON- PRP cord-010119-t1x9gknd 5205 2 plan plan VBP cord-010119-t1x9gknd 5205 3 to to TO cord-010119-t1x9gknd 5205 4 use use VB cord-010119-t1x9gknd 5205 5 these these DT cord-010119-t1x9gknd 5205 6 data datum NNS cord-010119-t1x9gknd 5205 7 to to TO cord-010119-t1x9gknd 5205 8 construct construct VB cord-010119-t1x9gknd 5205 9 Black black JJ cord-010119-t1x9gknd 5205 10 donor donor NN cord-010119-t1x9gknd 5205 11 recruitment recruitment NN cord-010119-t1x9gknd 5205 12 interventions intervention NNS cord-010119-t1x9gknd 5205 13 which which WDT cord-010119-t1x9gknd 5205 14 may may MD cord-010119-t1x9gknd 5205 15 be be VB cord-010119-t1x9gknd 5205 16 tested test VBN cord-010119-t1x9gknd 5205 17 using use VBG cord-010119-t1x9gknd 5205 18 randomized randomized JJ cord-010119-t1x9gknd 5205 19 trial trial NN cord-010119-t1x9gknd 5205 20 designs design NNS cord-010119-t1x9gknd 5205 21 . . . cord-010119-t1x9gknd 5206 1 Willingness willingness NN cord-010119-t1x9gknd 5206 2 to to TO cord-010119-t1x9gknd 5206 3 Donate donate VB cord-010119-t1x9gknd 5206 4 Blood blood NN cord-010119-t1x9gknd 5206 5 during during IN cord-010119-t1x9gknd 5206 6 the the DT cord-010119-t1x9gknd 5206 7 Summer Summer NNP cord-010119-t1x9gknd 5206 8 Christopher Christopher NNP cord-010119-t1x9gknd 5206 9 D D NNP cord-010119-t1x9gknd 5206 10 Bernard Bernard NNP cord-010119-t1x9gknd 5206 11 1 1 CD cord-010119-t1x9gknd 5206 12 , , , cord-010119-t1x9gknd 5206 13 Ramya Ramya NNP cord-010119-t1x9gknd 5206 14 Ghantasala Ghantasala NNP cord-010119-t1x9gknd 5206 15 1 1 CD cord-010119-t1x9gknd 5206 16 , , , cord-010119-t1x9gknd 5206 17 Obhijit Obhijit NNP cord-010119-t1x9gknd 5206 18 D D NNP cord-010119-t1x9gknd 5206 19 Hazarika Hazarika NNP cord-010119-t1x9gknd 5206 20 1 1 CD cord-010119-t1x9gknd 5206 21 , , , cord-010119-t1x9gknd 5206 22 Nicole Nicole NNP cord-010119-t1x9gknd 5206 23 Leonard Leonard NNP cord-010119-t1x9gknd 5206 24 1 1 CD cord-010119-t1x9gknd 5206 25 , , , cord-010119-t1x9gknd 5206 26 Cori Cori NNP cord-010119-t1x9gknd 5206 27 A A NNP cord-010119-t1x9gknd 5206 28 Polonski Polonski NNP cord-010119-t1x9gknd 5206 29 1 1 CD cord-010119-t1x9gknd 5206 30 , , , cord-010119-t1x9gknd 5206 31 Zachary Zachary NNP cord-010119-t1x9gknd 5206 32 B B NNP cord-010119-t1x9gknd 5206 33 Wunrow Wunrow NNP cord-010119-t1x9gknd 5206 34 1 1 CD cord-010119-t1x9gknd 5206 35 , , , cord-010119-t1x9gknd 5206 36 Michelle Michelle NNP cord-010119-t1x9gknd 5206 37 Heleba Heleba NNP cord-010119-t1x9gknd 5206 38 2 2 CD cord-010119-t1x9gknd 5206 39 , , , cord-010119-t1x9gknd 5206 40 Jan Jan NNP cord-010119-t1x9gknd 5206 41 K K NNP cord-010119-t1x9gknd 5206 42 Carney Carney NNP cord-010119-t1x9gknd 5206 43 1 1 CD cord-010119-t1x9gknd 5206 44 and and CC cord-010119-t1x9gknd 5206 45 Mark Mark NNP cord-010119-t1x9gknd 5206 46 K K NNP cord-010119-t1x9gknd 5206 47 Fung Fung NNP cord-010119-t1x9gknd 5206 48 * * NFP cord-010119-t1x9gknd 5206 49 1 1 CD cord-010119-t1x9gknd 5206 50 . . . cord-010119-t1x9gknd 5206 51 1 1 CD cord-010119-t1x9gknd 5206 52 University University NNP cord-010119-t1x9gknd 5206 53 of of IN cord-010119-t1x9gknd 5206 54 Vermont Vermont NNP cord-010119-t1x9gknd 5206 55 Larner Larner NNP cord-010119-t1x9gknd 5206 56 College College NNP cord-010119-t1x9gknd 5206 57 of of IN cord-010119-t1x9gknd 5206 58 Medicine Medicine NNP cord-010119-t1x9gknd 5206 59 , , , cord-010119-t1x9gknd 5206 60 2 2 CD cord-010119-t1x9gknd 5206 61 American American NNP cord-010119-t1x9gknd 5206 62 Red Red NNP cord-010119-t1x9gknd 5206 63 Cross Cross NNP cord-010119-t1x9gknd 5206 64 Blood Blood NNP cord-010119-t1x9gknd 5206 65 Services Services NNPS cord-010119-t1x9gknd 5206 66 Background Background NNP cord-010119-t1x9gknd 5206 67 / / SYM cord-010119-t1x9gknd 5206 68 Case Case NNP cord-010119-t1x9gknd 5206 69 Studies Studies NNPS cord-010119-t1x9gknd 5206 70 : : : cord-010119-t1x9gknd 5207 1 Each each DT cord-010119-t1x9gknd 5207 2 year year NN cord-010119-t1x9gknd 5207 3 donation donation NN cord-010119-t1x9gknd 5207 4 rates rate NNS cord-010119-t1x9gknd 5207 5 fall fall VBP cord-010119-t1x9gknd 5207 6 in in IN cord-010119-t1x9gknd 5207 7 the the DT cord-010119-t1x9gknd 5207 8 summer summer NN cord-010119-t1x9gknd 5207 9 months month NNS cord-010119-t1x9gknd 5207 10 straining strain VBG cord-010119-t1x9gknd 5207 11 blood blood NN cord-010119-t1x9gknd 5207 12 banks bank NNS cord-010119-t1x9gknd 5207 13 ' ' POS cord-010119-t1x9gknd 5207 14 capacities capacity NNS cord-010119-t1x9gknd 5207 15 to to TO cord-010119-t1x9gknd 5207 16 meet meet VB cord-010119-t1x9gknd 5207 17 local local JJ cord-010119-t1x9gknd 5207 18 demands demand NNS cord-010119-t1x9gknd 5207 19 . . . cord-010119-t1x9gknd 5208 1 In in IN cord-010119-t1x9gknd 5208 2 hopes hope NNS cord-010119-t1x9gknd 5208 3 of of IN cord-010119-t1x9gknd 5208 4 identifying identify VBG cord-010119-t1x9gknd 5208 5 factors factor NNS cord-010119-t1x9gknd 5208 6 to to TO cord-010119-t1x9gknd 5208 7 increase increase VB cord-010119-t1x9gknd 5208 8 summer summer NN cord-010119-t1x9gknd 5208 9 donations donation NNS cord-010119-t1x9gknd 5208 10 , , , cord-010119-t1x9gknd 5208 11 our -PRON- PRP$ cord-010119-t1x9gknd 5208 12 study study NN cord-010119-t1x9gknd 5208 13 investigated investigate VBD cord-010119-t1x9gknd 5208 14 donor donor NN cord-010119-t1x9gknd 5208 15 reported report VBD cord-010119-t1x9gknd 5208 16 barriers barrier NNS cord-010119-t1x9gknd 5208 17 which which WDT cord-010119-t1x9gknd 5208 18 influence influence VBP cord-010119-t1x9gknd 5208 19 summer summer NN cord-010119-t1x9gknd 5208 20 donations donation NNS cord-010119-t1x9gknd 5208 21 habits habit NNS cord-010119-t1x9gknd 5208 22 . . . cord-010119-t1x9gknd 5209 1 Study Study NNP cord-010119-t1x9gknd 5209 2 Design Design NNP cord-010119-t1x9gknd 5209 3 / / SYM cord-010119-t1x9gknd 5209 4 Method method NN cord-010119-t1x9gknd 5209 5 : : : cord-010119-t1x9gknd 5210 1 An an DT cord-010119-t1x9gknd 5210 2 anonymous anonymous JJ cord-010119-t1x9gknd 5210 3 16 16 CD cord-010119-t1x9gknd 5210 4 question question NN cord-010119-t1x9gknd 5210 5 survey survey NN cord-010119-t1x9gknd 5210 6 investigating investigate VBG cord-010119-t1x9gknd 5210 7 various various JJ cord-010119-t1x9gknd 5210 8 donation donation NN cord-010119-t1x9gknd 5210 9 factors factor NNS cord-010119-t1x9gknd 5210 10 was be VBD cord-010119-t1x9gknd 5210 11 administered administer VBN cord-010119-t1x9gknd 5210 12 across across IN cord-010119-t1x9gknd 5210 13 multiple multiple JJ cord-010119-t1x9gknd 5210 14 blood blood NN cord-010119-t1x9gknd 5210 15 donor donor NN cord-010119-t1x9gknd 5210 16 centers center NNS cord-010119-t1x9gknd 5210 17 in in IN cord-010119-t1x9gknd 5210 18 a a DT cord-010119-t1x9gknd 5210 19 state state NN cord-010119-t1x9gknd 5210 20 - - HYPH cord-010119-t1x9gknd 5210 21 wide wide JJ cord-010119-t1x9gknd 5210 22 region region NN cord-010119-t1x9gknd 5210 23 . . . cord-010119-t1x9gknd 5211 1 Questions question NNS cord-010119-t1x9gknd 5211 2 addressed address VBD cord-010119-t1x9gknd 5211 3 donor donor NN cord-010119-t1x9gknd 5211 4 demographics demographic NNS cord-010119-t1x9gknd 5211 5 , , , cord-010119-t1x9gknd 5211 6 frequency frequency NN cord-010119-t1x9gknd 5211 7 of of IN cord-010119-t1x9gknd 5211 8 blood blood NN cord-010119-t1x9gknd 5211 9 donation donation NN cord-010119-t1x9gknd 5211 10 , , , cord-010119-t1x9gknd 5211 11 preference preference NN cord-010119-t1x9gknd 5211 12 in in IN cord-010119-t1x9gknd 5211 13 appointment appointment NN cord-010119-t1x9gknd 5211 14 making make VBG cord-010119-t1x9gknd 5211 15 modalities modality NNS cord-010119-t1x9gknd 5211 16 including include VBG cord-010119-t1x9gknd 5211 17 smartphone smartphone NN cord-010119-t1x9gknd 5211 18 app app NN cord-010119-t1x9gknd 5211 19 use use NN cord-010119-t1x9gknd 5211 20 , , , cord-010119-t1x9gknd 5211 21 summer summer NN cord-010119-t1x9gknd 5211 22 travel travel NN cord-010119-t1x9gknd 5211 23 habits habit NNS cord-010119-t1x9gknd 5211 24 , , , cord-010119-t1x9gknd 5211 25 willingness willingness NN cord-010119-t1x9gknd 5211 26 to to TO cord-010119-t1x9gknd 5211 27 donate donate VB cord-010119-t1x9gknd 5211 28 during during IN cord-010119-t1x9gknd 5211 29 vacation vacation NN cord-010119-t1x9gknd 5211 30 , , , cord-010119-t1x9gknd 5211 31 and and CC cord-010119-t1x9gknd 5211 32 factors factor NNS cord-010119-t1x9gknd 5211 33 that that WDT cord-010119-t1x9gknd 5211 34 deter deter VBP cord-010119-t1x9gknd 5211 35 donors donor NNS cord-010119-t1x9gknd 5211 36 from from IN cord-010119-t1x9gknd 5211 37 donating donate VBG cord-010119-t1x9gknd 5211 38 on on IN cord-010119-t1x9gknd 5211 39 vacation vacation NN cord-010119-t1x9gknd 5211 40 . . . cord-010119-t1x9gknd 5212 1 Results/ Results/ . cord-010119-t1x9gknd 5213 1 Finding finding NN cord-010119-t1x9gknd 5213 2 : : : cord-010119-t1x9gknd 5213 3 A a DT cord-010119-t1x9gknd 5213 4 total total NN cord-010119-t1x9gknd 5213 5 of of IN cord-010119-t1x9gknd 5213 6 292 292 CD cord-010119-t1x9gknd 5213 7 surveys survey NNS cord-010119-t1x9gknd 5213 8 were be VBD cord-010119-t1x9gknd 5213 9 received receive VBN cord-010119-t1x9gknd 5213 10 . . . cord-010119-t1x9gknd 5214 1 Survey survey NN cord-010119-t1x9gknd 5214 2 respondents respondent NNS cord-010119-t1x9gknd 5214 3 across across IN cord-010119-t1x9gknd 5214 4 multiple multiple JJ cord-010119-t1x9gknd 5214 5 demographic demographic JJ cord-010119-t1x9gknd 5214 6 groups group NNS cord-010119-t1x9gknd 5214 7 cited cite VBD cord-010119-t1x9gknd 5214 8 similar similar JJ cord-010119-t1x9gknd 5214 9 barriers barrier NNS cord-010119-t1x9gknd 5214 10 to to IN cord-010119-t1x9gknd 5214 11 summer summer NN cord-010119-t1x9gknd 5214 12 donation donation NN cord-010119-t1x9gknd 5214 13 , , , cord-010119-t1x9gknd 5214 14 namely namely RB cord-010119-t1x9gknd 5214 15 " " `` cord-010119-t1x9gknd 5214 16 Too too RB cord-010119-t1x9gknd 5214 17 busy busy JJ cord-010119-t1x9gknd 5214 18 " " '' cord-010119-t1x9gknd 5214 19 ( ( -LRB- cord-010119-t1x9gknd 5214 20 27.5 27.5 CD cord-010119-t1x9gknd 5214 21 % % NN cord-010119-t1x9gknd 5214 22 ) ) -RRB- cord-010119-t1x9gknd 5214 23 and and CC cord-010119-t1x9gknd 5214 24 " " `` cord-010119-t1x9gknd 5214 25 Traveling travel VBG cord-010119-t1x9gknd 5214 26 is be VBZ cord-010119-t1x9gknd 5214 27 a a DT cord-010119-t1x9gknd 5214 28 time time NN cord-010119-t1x9gknd 5214 29 for for IN cord-010119-t1x9gknd 5214 30 me -PRON- PRP cord-010119-t1x9gknd 5214 31 to to TO cord-010119-t1x9gknd 5214 32 relax relax VB cord-010119-t1x9gknd 5214 33 . . . cord-010119-t1x9gknd 5214 34 " " '' cord-010119-t1x9gknd 5214 35 ( ( -LRB- cord-010119-t1x9gknd 5214 36 30.6 30.6 CD cord-010119-t1x9gknd 5214 37 % % NN cord-010119-t1x9gknd 5214 38 ) ) -RRB- cord-010119-t1x9gknd 5214 39 . . . cord-010119-t1x9gknd 5215 1 Of of IN cord-010119-t1x9gknd 5215 2 the the DT cord-010119-t1x9gknd 5215 3 respondents respondent NNS cord-010119-t1x9gknd 5215 4 who who WP cord-010119-t1x9gknd 5215 5 travel travel VBP cord-010119-t1x9gknd 5215 6 in in IN cord-010119-t1x9gknd 5215 7 the the DT cord-010119-t1x9gknd 5215 8 summer summer NN cord-010119-t1x9gknd 5215 9 , , , cord-010119-t1x9gknd 5215 10 very very RB cord-010119-t1x9gknd 5215 11 few few JJ cord-010119-t1x9gknd 5215 12 reported report VBN cord-010119-t1x9gknd 5215 13 donating donate VBG cord-010119-t1x9gknd 5215 14 while while IN cord-010119-t1x9gknd 5215 15 traveling travel VBG cord-010119-t1x9gknd 5215 16 ( ( -LRB- cord-010119-t1x9gknd 5215 17 3.4 3.4 CD cord-010119-t1x9gknd 5215 18 % % NN cord-010119-t1x9gknd 5215 19 ) ) -RRB- cord-010119-t1x9gknd 5215 20 . . . cord-010119-t1x9gknd 5216 1 Summer summer NN cord-010119-t1x9gknd 5216 2 donation donation NN cord-010119-t1x9gknd 5216 3 rates rate NNS cord-010119-t1x9gknd 5216 4 between between IN cord-010119-t1x9gknd 5216 5 summertime summertime JJ cord-010119-t1x9gknd 5216 6 travelers traveler NNS cord-010119-t1x9gknd 5216 7 ( ( -LRB- cord-010119-t1x9gknd 5216 8 36.5 36.5 CD cord-010119-t1x9gknd 5216 9 % % NN cord-010119-t1x9gknd 5216 10 ) ) -RRB- cord-010119-t1x9gknd 5216 11 and and CC cord-010119-t1x9gknd 5216 12 non non NNS cord-010119-t1x9gknd 5216 13 - - NNS cord-010119-t1x9gknd 5216 14 travelers traveler NNS cord-010119-t1x9gknd 5216 15 ( ( -LRB- cord-010119-t1x9gknd 5216 16 36.4 36.4 CD cord-010119-t1x9gknd 5216 17 % % NN cord-010119-t1x9gknd 5216 18 ) ) -RRB- cord-010119-t1x9gknd 5216 19 were be VBD cord-010119-t1x9gknd 5216 20 essentially essentially RB cord-010119-t1x9gknd 5216 21 equivalent equivalent JJ cord-010119-t1x9gknd 5216 22 . . . cord-010119-t1x9gknd 5217 1 The the DT cord-010119-t1x9gknd 5217 2 most most RBS cord-010119-t1x9gknd 5217 3 preferred preferred JJ cord-010119-t1x9gknd 5217 4 methods method NNS cord-010119-t1x9gknd 5217 5 of of IN cord-010119-t1x9gknd 5217 6 scheduling scheduling NN cord-010119-t1x9gknd 5217 7 appointments appointment NNS cord-010119-t1x9gknd 5217 8 were be VBD cord-010119-t1x9gknd 5217 9 via via IN cord-010119-t1x9gknd 5217 10 the the DT cord-010119-t1x9gknd 5217 11 regional regional JJ cord-010119-t1x9gknd 5217 12 blood blood NN cord-010119-t1x9gknd 5217 13 donor donor NN cord-010119-t1x9gknd 5217 14 center center NN cord-010119-t1x9gknd 5217 15 website website NN cord-010119-t1x9gknd 5217 16 ( ( -LRB- cord-010119-t1x9gknd 5217 17 45.6 45.6 CD cord-010119-t1x9gknd 5217 18 % % NN cord-010119-t1x9gknd 5217 19 ) ) -RRB- cord-010119-t1x9gknd 5217 20 and and CC cord-010119-t1x9gknd 5217 21 phone phone NN cord-010119-t1x9gknd 5217 22 ( ( -LRB- cord-010119-t1x9gknd 5217 23 28.4 28.4 CD cord-010119-t1x9gknd 5217 24 % % NN cord-010119-t1x9gknd 5217 25 ) ) -RRB- cord-010119-t1x9gknd 5217 26 . . . cord-010119-t1x9gknd 5218 1 Willingness willingness NN cord-010119-t1x9gknd 5218 2 to to TO cord-010119-t1x9gknd 5218 3 use use VB cord-010119-t1x9gknd 5218 4 a a DT cord-010119-t1x9gknd 5218 5 regional regional JJ cord-010119-t1x9gknd 5218 6 blood blood NN cord-010119-t1x9gknd 5218 7 donation donation NN cord-010119-t1x9gknd 5218 8 smartphone smartphone NN cord-010119-t1x9gknd 5218 9 app app NN cord-010119-t1x9gknd 5218 10 was be VBD cord-010119-t1x9gknd 5218 11 highest high JJS cord-010119-t1x9gknd 5218 12 among among IN cord-010119-t1x9gknd 5218 13 respondents respondent NNS cord-010119-t1x9gknd 5218 14 ages age NNS cord-010119-t1x9gknd 5218 15 of of IN cord-010119-t1x9gknd 5218 16 18 18 CD cord-010119-t1x9gknd 5218 17 to to TO cord-010119-t1x9gknd 5218 18 34 34 CD cord-010119-t1x9gknd 5218 19 ( ( -LRB- cord-010119-t1x9gknd 5218 20 45 45 CD cord-010119-t1x9gknd 5218 21 - - SYM cord-010119-t1x9gknd 5218 22 55 55 CD cord-010119-t1x9gknd 5218 23 % % NN cord-010119-t1x9gknd 5218 24 ) ) -RRB- cord-010119-t1x9gknd 5218 25 and and CC cord-010119-t1x9gknd 5218 26 lowest low JJS cord-010119-t1x9gknd 5218 27 among among IN cord-010119-t1x9gknd 5218 28 ages age NNS cord-010119-t1x9gknd 5218 29 55 55 CD cord-010119-t1x9gknd 5218 30 and and CC cord-010119-t1x9gknd 5218 31 older old JJR cord-010119-t1x9gknd 5218 32 ( ( -LRB- cord-010119-t1x9gknd 5218 33 13 13 CD cord-010119-t1x9gknd 5218 34 - - SYM cord-010119-t1x9gknd 5218 35 15 15 CD cord-010119-t1x9gknd 5218 36 % % NN cord-010119-t1x9gknd 5218 37 ) ) -RRB- cord-010119-t1x9gknd 5218 38 . . . cord-010119-t1x9gknd 5219 1 Of of IN cord-010119-t1x9gknd 5219 2 respondents respondent NNS cord-010119-t1x9gknd 5219 3 with with IN cord-010119-t1x9gknd 5219 4 no no DT cord-010119-t1x9gknd 5219 5 prior prior JJ cord-010119-t1x9gknd 5219 6 knowledge knowledge NN cord-010119-t1x9gknd 5219 7 of of IN cord-010119-t1x9gknd 5219 8 summer summer NN cord-010119-t1x9gknd 5219 9 seasonal seasonal JJ cord-010119-t1x9gknd 5219 10 shortages shortage NNS cord-010119-t1x9gknd 5219 11 ( ( -LRB- cord-010119-t1x9gknd 5219 12 22 22 CD cord-010119-t1x9gknd 5219 13 % % NN cord-010119-t1x9gknd 5219 14 ) ) -RRB- cord-010119-t1x9gknd 5219 15 , , , cord-010119-t1x9gknd 5219 16 2/3rds 2/3rds NNP cord-010119-t1x9gknd 5219 17 indicated indicate VBD cord-010119-t1x9gknd 5219 18 newfound newfound JJ cord-010119-t1x9gknd 5219 19 motivation motivation NN cord-010119-t1x9gknd 5219 20 to to TO cord-010119-t1x9gknd 5219 21 donate donate VB cord-010119-t1x9gknd 5219 22 . . . cord-010119-t1x9gknd 5220 1 Background Background NNP cord-010119-t1x9gknd 5220 2 / / SYM cord-010119-t1x9gknd 5220 3 Case Case NNP cord-010119-t1x9gknd 5220 4 Studies Studies NNPS cord-010119-t1x9gknd 5220 5 : : : cord-010119-t1x9gknd 5220 6 Viral viral JJ cord-010119-t1x9gknd 5220 7 infections infection NNS cord-010119-t1x9gknd 5220 8 ( ( -LRB- cord-010119-t1x9gknd 5220 9 Adenovirus Adenovirus NNP cord-010119-t1x9gknd 5220 10 , , , cord-010119-t1x9gknd 5220 11 EBV EBV NNP cord-010119-t1x9gknd 5220 12 , , , cord-010119-t1x9gknd 5220 13 CMV CMV NNP cord-010119-t1x9gknd 5220 14 , , , cord-010119-t1x9gknd 5220 15 BK BK NNP cord-010119-t1x9gknd 5220 16 , , , cord-010119-t1x9gknd 5220 17 HHV6 HHV6 NNP cord-010119-t1x9gknd 5220 18 , , , cord-010119-t1x9gknd 5220 19 and and CC cord-010119-t1x9gknd 5220 20 RSV RSV NNP cord-010119-t1x9gknd 5220 21 etc etc FW cord-010119-t1x9gknd 5220 22 . . . cord-010119-t1x9gknd 5220 23 ) ) -RRB- cord-010119-t1x9gknd 5220 24 have have VBP cord-010119-t1x9gknd 5220 25 been be VBN cord-010119-t1x9gknd 5220 26 implicated implicate VBN cord-010119-t1x9gknd 5220 27 as as IN cord-010119-t1x9gknd 5220 28 major major JJ cord-010119-t1x9gknd 5220 29 contributors contributor NNS cord-010119-t1x9gknd 5220 30 to to IN cord-010119-t1x9gknd 5220 31 posttransplant posttransplant VB cord-010119-t1x9gknd 5220 32 morbidity morbidity NN cord-010119-t1x9gknd 5220 33 and and CC cord-010119-t1x9gknd 5220 34 mortality mortality NN cord-010119-t1x9gknd 5220 35 in in IN cord-010119-t1x9gknd 5220 36 Hematopoietic Hematopoietic NNP cord-010119-t1x9gknd 5220 37 stem stem NN cord-010119-t1x9gknd 5220 38 cell cell NN cord-010119-t1x9gknd 5220 39 transplantation transplantation NN cord-010119-t1x9gknd 5220 40 ( ( -LRB- cord-010119-t1x9gknd 5220 41 HSCT HSCT NNP cord-010119-t1x9gknd 5220 42 ) ) -RRB- cord-010119-t1x9gknd 5220 43 from from IN cord-010119-t1x9gknd 5220 44 unrelated unrelated JJ cord-010119-t1x9gknd 5220 45 donors donor NNS cord-010119-t1x9gknd 5220 46 . . . cord-010119-t1x9gknd 5221 1 Investigators investigator NNS cord-010119-t1x9gknd 5221 2 have have VBP cord-010119-t1x9gknd 5221 3 shown show VBN cord-010119-t1x9gknd 5221 4 that that IN cord-010119-t1x9gknd 5221 5 in in IN cord-010119-t1x9gknd 5221 6 - - HYPH cord-010119-t1x9gknd 5221 7 vitro vitro FW cord-010119-t1x9gknd 5221 8 expanded expand VBN cord-010119-t1x9gknd 5221 9 virus virus NN cord-010119-t1x9gknd 5221 10 specific specific JJ cord-010119-t1x9gknd 5221 11 cytotoxic cytotoxic JJ cord-010119-t1x9gknd 5221 12 T t NN cord-010119-t1x9gknd 5221 13 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 5221 14 ( ( -LRB- cord-010119-t1x9gknd 5221 15 CTLs CTLs NNP cord-010119-t1x9gknd 5221 16 ) ) -RRB- cord-010119-t1x9gknd 5221 17 generated generate VBN cord-010119-t1x9gknd 5221 18 from from IN cord-010119-t1x9gknd 5221 19 donors donor NNS cord-010119-t1x9gknd 5221 20 with with IN cord-010119-t1x9gknd 5221 21 specificity specificity NN cord-010119-t1x9gknd 5221 22 for for IN cord-010119-t1x9gknd 5221 23 one one CD cord-010119-t1x9gknd 5221 24 or or CC cord-010119-t1x9gknd 5221 25 more more JJR cord-010119-t1x9gknd 5221 26 viruses virus NNS cord-010119-t1x9gknd 5221 27 are be VBP cord-010119-t1x9gknd 5221 28 safe safe JJ cord-010119-t1x9gknd 5221 29 and and CC cord-010119-t1x9gknd 5221 30 effectively effectively RB cord-010119-t1x9gknd 5221 31 treat treat VB cord-010119-t1x9gknd 5221 32 viral viral JJ cord-010119-t1x9gknd 5221 33 infections infection NNS cord-010119-t1x9gknd 5221 34 in in IN cord-010119-t1x9gknd 5221 35 the the DT cord-010119-t1x9gknd 5221 36 HSCT HSCT NNP cord-010119-t1x9gknd 5221 37 setting set VBG cord-010119-t1x9gknd 5221 38 in in IN cord-010119-t1x9gknd 5221 39 recent recent JJ cord-010119-t1x9gknd 5221 40 clinical clinical JJ cord-010119-t1x9gknd 5221 41 trials trial NNS cord-010119-t1x9gknd 5221 42 . . . cord-010119-t1x9gknd 5222 1 Present present JJ cord-010119-t1x9gknd 5222 2 clinical clinical JJ cord-010119-t1x9gknd 5222 3 trials trial NNS cord-010119-t1x9gknd 5222 4 have have VBP cord-010119-t1x9gknd 5222 5 shown show VBN cord-010119-t1x9gknd 5222 6 that that IN cord-010119-t1x9gknd 5222 7 CTLs ctl NNS cord-010119-t1x9gknd 5222 8 can can MD cord-010119-t1x9gknd 5222 9 be be VB cord-010119-t1x9gknd 5222 10 rapidly rapidly RB cord-010119-t1x9gknd 5222 11 produced produce VBN cord-010119-t1x9gknd 5222 12 by by IN cord-010119-t1x9gknd 5222 13 a a DT cord-010119-t1x9gknd 5222 14 single single JJ cord-010119-t1x9gknd 5222 15 stimulation stimulation NN cord-010119-t1x9gknd 5222 16 of of IN cord-010119-t1x9gknd 5222 17 donor donor NN cord-010119-t1x9gknd 5222 18 peripheral peripheral JJ cord-010119-t1x9gknd 5222 19 blood blood NN cord-010119-t1x9gknd 5222 20 mononuclear mononuclear NN cord-010119-t1x9gknd 5222 21 cells cell NNS cord-010119-t1x9gknd 5222 22 ( ( -LRB- cord-010119-t1x9gknd 5222 23 PBMCs pbmc NNS cord-010119-t1x9gknd 5222 24 ) ) -RRB- cord-010119-t1x9gknd 5222 25 with with IN cord-010119-t1x9gknd 5222 26 a a DT cord-010119-t1x9gknd 5222 27 peptide peptide NN cord-010119-t1x9gknd 5222 28 - - HYPH cord-010119-t1x9gknd 5222 29 mixture mixture NN cord-010119-t1x9gknd 5222 30 spanning span VBG cord-010119-t1x9gknd 5222 31 the the DT cord-010119-t1x9gknd 5222 32 target target NN cord-010119-t1x9gknd 5222 33 antigens antigen NNS cord-010119-t1x9gknd 5222 34 in in IN cord-010119-t1x9gknd 5222 35 the the DT cord-010119-t1x9gknd 5222 36 presence presence NN cord-010119-t1x9gknd 5222 37 of of IN cord-010119-t1x9gknd 5222 38 potent potent JJ cord-010119-t1x9gknd 5222 39 prosurvival prosurvival NNP cord-010119-t1x9gknd 5222 40 cytokines cytokine NNS cord-010119-t1x9gknd 5222 41 interleukin-4(IL-4 interleukin-4(IL-4 NFP cord-010119-t1x9gknd 5222 42 ) ) -RRB- cord-010119-t1x9gknd 5222 43 and and CC cord-010119-t1x9gknd 5222 44 IL7 IL7 NNP cord-010119-t1x9gknd 5222 45 . . . cord-010119-t1x9gknd 5223 1 Others other NNS cord-010119-t1x9gknd 5223 2 have have VBP cord-010119-t1x9gknd 5223 3 used use VBN cord-010119-t1x9gknd 5223 4 banked bank VBN cord-010119-t1x9gknd 5223 5 third third JJ cord-010119-t1x9gknd 5223 6 party party NN cord-010119-t1x9gknd 5223 7 Epstein Epstein NNP cord-010119-t1x9gknd 5223 8 Barr Barr NNP cord-010119-t1x9gknd 5223 9 Virus Virus NNP cord-010119-t1x9gknd 5223 10 ( ( -LRB- cord-010119-t1x9gknd 5223 11 EBV)-specific ebv)-specific NN cord-010119-t1x9gknd 5223 12 CTLs ctl NNS cord-010119-t1x9gknd 5223 13 generated generate VBN cord-010119-t1x9gknd 5223 14 from from IN cord-010119-t1x9gknd 5223 15 third third JJ cord-010119-t1x9gknd 5223 16 party party NN cord-010119-t1x9gknd 5223 17 EBV EBV NNP cord-010119-t1x9gknd 5223 18 - - HYPH cord-010119-t1x9gknd 5223 19 seropositive seropositive JJ cord-010119-t1x9gknd 5223 20 blood blood NN cord-010119-t1x9gknd 5223 21 donors donor NNS cord-010119-t1x9gknd 5223 22 with with IN cord-010119-t1x9gknd 5223 23 encouraging encouraging JJ cord-010119-t1x9gknd 5223 24 results result NNS cord-010119-t1x9gknd 5223 25 . . . cord-010119-t1x9gknd 5224 1 Study Study NNP cord-010119-t1x9gknd 5224 2 Design Design NNP cord-010119-t1x9gknd 5224 3 / / SYM cord-010119-t1x9gknd 5224 4 Methods method NNS cord-010119-t1x9gknd 5224 5 : : : cord-010119-t1x9gknd 5225 1 Eligible eligible JJ cord-010119-t1x9gknd 5225 2 and and CC cord-010119-t1x9gknd 5225 3 consented consent VBD cord-010119-t1x9gknd 5225 4 Blood blood NN cord-010119-t1x9gknd 5225 5 donors donor NNS cord-010119-t1x9gknd 5225 6 were be VBD cord-010119-t1x9gknd 5225 7 tested test VBN cord-010119-t1x9gknd 5225 8 for for IN cord-010119-t1x9gknd 5225 9 CMV CMV NNP cord-010119-t1x9gknd 5225 10 antibodies antibody NNS cord-010119-t1x9gknd 5225 11 by by IN cord-010119-t1x9gknd 5225 12 serology serology NN cord-010119-t1x9gknd 5225 13 . . . cord-010119-t1x9gknd 5226 1 CMV CMV NNP cord-010119-t1x9gknd 5226 2 - - HYPH cord-010119-t1x9gknd 5226 3 seropositive seropositive JJ cord-010119-t1x9gknd 5226 4 Whole whole JJ cord-010119-t1x9gknd 5226 5 Blood blood NN cord-010119-t1x9gknd 5226 6 ( ( -LRB- cord-010119-t1x9gknd 5226 7 WB WB NNP cord-010119-t1x9gknd 5226 8 ) ) -RRB- cord-010119-t1x9gknd 5226 9 units unit NNS cord-010119-t1x9gknd 5226 10 underwent undergo VBD cord-010119-t1x9gknd 5226 11 buffy buffy NNP cord-010119-t1x9gknd 5226 12 coats coat NNS cord-010119-t1x9gknd 5226 13 processing process VBG cord-010119-t1x9gknd 5226 14 from from IN cord-010119-t1x9gknd 5226 15 non non JJ cord-010119-t1x9gknd 5226 16 - - JJ cord-010119-t1x9gknd 5226 17 leucocyte leucocyte RB cord-010119-t1x9gknd 5226 18 reduced reduce VBN cord-010119-t1x9gknd 5226 19 WB WB NNP cord-010119-t1x9gknd 5226 20 units unit NNS cord-010119-t1x9gknd 5226 21 collected collect VBN cord-010119-t1x9gknd 5226 22 in in IN cord-010119-t1x9gknd 5226 23 Fenwal Fenwal NNP cord-010119-t1x9gknd 5226 24 triple triple JJ cord-010119-t1x9gknd 5226 25 Blood blood NN cord-010119-t1x9gknd 5226 26 - - HYPH cord-010119-t1x9gknd 5226 27 Packs Packs NNP cord-010119-t1x9gknd 5226 28 TM TM NNP cord-010119-t1x9gknd 5226 29 that that WDT cord-010119-t1x9gknd 5226 30 underwent undergo VBD cord-010119-t1x9gknd 5226 31 2 2 CD cord-010119-t1x9gknd 5226 32 hard hard JJ cord-010119-t1x9gknd 5226 33 spins spin NNS cord-010119-t1x9gknd 5226 34 at at IN cord-010119-t1x9gknd 5226 35 3800 3800 CD cord-010119-t1x9gknd 5226 36 rpm rpm NN cord-010119-t1x9gknd 5226 37 for for IN cord-010119-t1x9gknd 5226 38 7 7 CD cord-010119-t1x9gknd 5226 39 minutes minute NNS cord-010119-t1x9gknd 5226 40 with with IN cord-010119-t1x9gknd 5226 41 separation separation NN cord-010119-t1x9gknd 5226 42 after after IN cord-010119-t1x9gknd 5226 43 each each DT cord-010119-t1x9gknd 5226 44 spin spin NN cord-010119-t1x9gknd 5226 45 on on IN cord-010119-t1x9gknd 5226 46 a a DT cord-010119-t1x9gknd 5226 47 CompoMateV CompoMateV NNP cord-010119-t1x9gknd 5226 48 R R NNP cord-010119-t1x9gknd 5226 49 G5 G5 NNP cord-010119-t1x9gknd 5226 50 . . . cord-010119-t1x9gknd 5227 1 Plasma Plasma NNP cord-010119-t1x9gknd 5227 2 and and CC cord-010119-t1x9gknd 5227 3 buffy buffy NNP cord-010119-t1x9gknd 5227 4 coat coat NNP cord-010119-t1x9gknd 5227 5 was be VBD cord-010119-t1x9gknd 5227 6 separated separate VBN cord-010119-t1x9gknd 5227 7 from from IN cord-010119-t1x9gknd 5227 8 red red JJ cord-010119-t1x9gknd 5227 9 cells cell NNS cord-010119-t1x9gknd 5227 10 after after IN cord-010119-t1x9gknd 5227 11 the the DT cord-010119-t1x9gknd 5227 12 first first JJ cord-010119-t1x9gknd 5227 13 spin spin NN cord-010119-t1x9gknd 5227 14 . . . cord-010119-t1x9gknd 5228 1 The the DT cord-010119-t1x9gknd 5228 2 second second JJ cord-010119-t1x9gknd 5228 3 spin spin NN cord-010119-t1x9gknd 5228 4 lead lead NN cord-010119-t1x9gknd 5228 5 to to IN cord-010119-t1x9gknd 5228 6 the the DT cord-010119-t1x9gknd 5228 7 separation separation NN cord-010119-t1x9gknd 5228 8 of of IN cord-010119-t1x9gknd 5228 9 the the DT cord-010119-t1x9gknd 5228 10 buffy buffy NNP cord-010119-t1x9gknd 5228 11 coat coat NN cord-010119-t1x9gknd 5228 12 from from IN cord-010119-t1x9gknd 5228 13 plasma plasma NN cord-010119-t1x9gknd 5228 14 . . . cord-010119-t1x9gknd 5229 1 The the DT cord-010119-t1x9gknd 5229 2 buffy buffy NNP cord-010119-t1x9gknd 5229 3 coats coat NNS cord-010119-t1x9gknd 5229 4 were be VBD cord-010119-t1x9gknd 5229 5 submitted submit VBN cord-010119-t1x9gknd 5229 6 to to IN cord-010119-t1x9gknd 5229 7 the the DT cord-010119-t1x9gknd 5229 8 GMP GMP NNP cord-010119-t1x9gknd 5229 9 Stem Stem NNP cord-010119-t1x9gknd 5229 10 Cell Cell NNP cord-010119-t1x9gknd 5229 11 Lab Lab NNP cord-010119-t1x9gknd 5229 12 for for IN cord-010119-t1x9gknd 5229 13 processing processing NN cord-010119-t1x9gknd 5229 14 of of IN cord-010119-t1x9gknd 5229 15 Cytomegalovirus Cytomegalovirus NNP cord-010119-t1x9gknd 5229 16 - - HYPH cord-010119-t1x9gknd 5229 17 specific specific JJ cord-010119-t1x9gknd 5229 18 CTLs ctl NNS cord-010119-t1x9gknd 5229 19 . . . cord-010119-t1x9gknd 5230 1 HLA HLA NNP cord-010119-t1x9gknd 5230 2 typing type VBG cord-010119-t1x9gknd 5230 3 at at IN cord-010119-t1x9gknd 5230 4 high high JJ cord-010119-t1x9gknd 5230 5 resolution resolution NN cord-010119-t1x9gknd 5230 6 for for IN cord-010119-t1x9gknd 5230 7 HLA HLA NNP cord-010119-t1x9gknd 5230 8 - - HYPH cord-010119-t1x9gknd 5230 9 A/-B/-DRB1 A/-B/-DRB1 NNP cord-010119-t1x9gknd 5230 10 loci locus NNS cord-010119-t1x9gknd 5230 11 was be VBD cord-010119-t1x9gknd 5230 12 obtained obtain VBN cord-010119-t1x9gknd 5230 13 for for IN cord-010119-t1x9gknd 5230 14 all all DT cord-010119-t1x9gknd 5230 15 donors donor NNS cord-010119-t1x9gknd 5230 16 . . . cord-010119-t1x9gknd 5231 1 Results result NNS cord-010119-t1x9gknd 5231 2 / / SYM cord-010119-t1x9gknd 5231 3 Findings finding NNS cord-010119-t1x9gknd 5231 4 : : : cord-010119-t1x9gknd 5232 1 Forty forty CD cord-010119-t1x9gknd 5232 2 five five CD cord-010119-t1x9gknd 5232 3 eligible eligible JJ cord-010119-t1x9gknd 5232 4 healthy healthy JJ cord-010119-t1x9gknd 5232 5 blood blood NN cord-010119-t1x9gknd 5232 6 volunteers volunteer NNS cord-010119-t1x9gknd 5232 7 ( ( -LRB- cord-010119-t1x9gknd 5232 8 13 13 CD cord-010119-t1x9gknd 5232 9 M M NNP cord-010119-t1x9gknd 5232 10 [ [ -LRB- cord-010119-t1x9gknd 5232 11 29 29 CD cord-010119-t1x9gknd 5232 12 % % NN cord-010119-t1x9gknd 5232 13 ] ] -RRB- cord-010119-t1x9gknd 5232 14 : : : cord-010119-t1x9gknd 5232 15 32 32 CD cord-010119-t1x9gknd 5232 16 [ [ -LRB- cord-010119-t1x9gknd 5232 17 71 71 CD cord-010119-t1x9gknd 5232 18 % % NN cord-010119-t1x9gknd 5232 19 ] ] -RRB- cord-010119-t1x9gknd 5232 20 F F NNP cord-010119-t1x9gknd 5232 21 ) ) -RRB- cord-010119-t1x9gknd 5232 22 ; ; : cord-010119-t1x9gknd 5232 23 median median JJ cord-010119-t1x9gknd 5232 24 age age NN cord-010119-t1x9gknd 5232 25 42 42 CD cord-010119-t1x9gknd 5232 26 years year NNS cord-010119-t1x9gknd 5233 1 ( ( -LRB- cord-010119-t1x9gknd 5233 2 range range NNP cord-010119-t1x9gknd 5233 3 21 21 CD cord-010119-t1x9gknd 5233 4 - - SYM cord-010119-t1x9gknd 5233 5 70 70 CD cord-010119-t1x9gknd 5233 6 ) ) -RRB- cord-010119-t1x9gknd 5233 7 donated donate VBD cord-010119-t1x9gknd 5233 8 a a DT cord-010119-t1x9gknd 5233 9 unit unit NN cord-010119-t1x9gknd 5233 10 ( ( -LRB- cord-010119-t1x9gknd 5233 11 500 500 CD cord-010119-t1x9gknd 5233 12 mL ml NN cord-010119-t1x9gknd 5233 13 ) ) -RRB- cord-010119-t1x9gknd 5233 14 blood blood NN cord-010119-t1x9gknd 5233 15 from from IN cord-010119-t1x9gknd 5233 16 which which WDT cord-010119-t1x9gknd 5233 17 buffy buffy NNP cord-010119-t1x9gknd 5233 18 coats coat NNS cord-010119-t1x9gknd 5233 19 ( ( -LRB- cord-010119-t1x9gknd 5233 20 average average JJ cord-010119-t1x9gknd 5233 21 volume volume NN cord-010119-t1x9gknd 5233 22 56 56 CD cord-010119-t1x9gknd 5233 23 ml ml NNS cord-010119-t1x9gknd 5233 24 ) ) -RRB- cord-010119-t1x9gknd 5233 25 were be VBD cord-010119-t1x9gknd 5233 26 processed process VBN cord-010119-t1x9gknd 5233 27 . . . cord-010119-t1x9gknd 5234 1 The the DT cord-010119-t1x9gknd 5234 2 buffy buffy NNP cord-010119-t1x9gknd 5234 3 coat coat NN cord-010119-t1x9gknd 5234 4 process process NN cord-010119-t1x9gknd 5234 5 was be VBD cord-010119-t1x9gknd 5234 6 previously previously RB cord-010119-t1x9gknd 5234 7 validated validate VBN cord-010119-t1x9gknd 5234 8 on on IN cord-010119-t1x9gknd 5234 9 20 20 CD cord-010119-t1x9gknd 5234 10 WB WB NNP cord-010119-t1x9gknd 5234 11 units unit NNS cord-010119-t1x9gknd 5234 12 . . . cord-010119-t1x9gknd 5235 1 The the DT cord-010119-t1x9gknd 5235 2 mononuclear mononuclear NN cord-010119-t1x9gknd 5235 3 cells cell NNS cord-010119-t1x9gknd 5235 4 ( ( -LRB- cord-010119-t1x9gknd 5235 5 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 5235 6 and and CC cord-010119-t1x9gknd 5235 7 monocytes monocyte NNS cord-010119-t1x9gknd 5235 8 ) ) -RRB- cord-010119-t1x9gknd 5235 9 recovered recover VBD cord-010119-t1x9gknd 5235 10 from from IN cord-010119-t1x9gknd 5235 11 the the DT cord-010119-t1x9gknd 5235 12 buffy buffy NNP cord-010119-t1x9gknd 5235 13 coats coat NNS cord-010119-t1x9gknd 5235 14 are be VBP cord-010119-t1x9gknd 5235 15 listed list VBN cord-010119-t1x9gknd 5235 16 in in IN cord-010119-t1x9gknd 5235 17 figures figure NNS cord-010119-t1x9gknd 5235 18 1 1 CD cord-010119-t1x9gknd 5235 19 and and CC cord-010119-t1x9gknd 5235 20 2 2 CD cord-010119-t1x9gknd 5235 21 . . . cord-010119-t1x9gknd 5236 1 All all DT cord-010119-t1x9gknd 5236 2 of of IN cord-010119-t1x9gknd 5236 3 the the DT cord-010119-t1x9gknd 5236 4 buffy buffy NNP cord-010119-t1x9gknd 5236 5 coats coat NNS cord-010119-t1x9gknd 5236 6 received receive VBN cord-010119-t1x9gknd 5236 7 by by IN cord-010119-t1x9gknd 5236 8 the the DT cord-010119-t1x9gknd 5236 9 GMP GMP NNP cord-010119-t1x9gknd 5236 10 Stem Stem NNP cord-010119-t1x9gknd 5236 11 Cell Cell NNP cord-010119-t1x9gknd 5236 12 Lab Lab NNP cord-010119-t1x9gknd 5236 13 were be VBD cord-010119-t1x9gknd 5236 14 adequate adequate JJ cord-010119-t1x9gknd 5236 15 in in IN cord-010119-t1x9gknd 5236 16 cell cell NN cord-010119-t1x9gknd 5236 17 numbers number NNS cord-010119-t1x9gknd 5236 18 to to TO cord-010119-t1x9gknd 5236 19 be be VB cord-010119-t1x9gknd 5236 20 processed process VBN cord-010119-t1x9gknd 5236 21 . . . cord-010119-t1x9gknd 5237 1 The the DT cord-010119-t1x9gknd 5237 2 processing processing NN cord-010119-t1x9gknd 5237 3 of of IN cord-010119-t1x9gknd 5237 4 buffy buffy NNP cord-010119-t1x9gknd 5237 5 coats coat NNS cord-010119-t1x9gknd 5237 6 from from IN cord-010119-t1x9gknd 5237 7 whole whole JJ cord-010119-t1x9gknd 5237 8 blood blood NN cord-010119-t1x9gknd 5237 9 is be VBZ cord-010119-t1x9gknd 5237 10 a a DT cord-010119-t1x9gknd 5237 11 viable viable JJ cord-010119-t1x9gknd 5237 12 option option NN cord-010119-t1x9gknd 5237 13 for for IN cord-010119-t1x9gknd 5237 14 the the DT cord-010119-t1x9gknd 5237 15 concentration concentration NN cord-010119-t1x9gknd 5237 16 of of IN cord-010119-t1x9gknd 5237 17 PBMCs PBMCs NNP cord-010119-t1x9gknd 5237 18 specifically specifically RB cord-010119-t1x9gknd 5237 19 for for IN cord-010119-t1x9gknd 5237 20 production production NN cord-010119-t1x9gknd 5237 21 of of IN cord-010119-t1x9gknd 5237 22 viral viral JJ cord-010119-t1x9gknd 5237 23 specific specific JJ cord-010119-t1x9gknd 5237 24 CTLs ctl NNS cord-010119-t1x9gknd 5237 25 as as IN cord-010119-t1x9gknd 5237 26 third third JJ cord-010119-t1x9gknd 5237 27 party party NN cord-010119-t1x9gknd 5237 28 off off IN cord-010119-t1x9gknd 5237 29 the the DT cord-010119-t1x9gknd 5237 30 shelf shelf NN cord-010119-t1x9gknd 5237 31 products product NNS cord-010119-t1x9gknd 5237 32 as as RB cord-010119-t1x9gknd 5237 33 well well RB cord-010119-t1x9gknd 5237 34 as as IN cord-010119-t1x9gknd 5237 35 use use NN cord-010119-t1x9gknd 5237 36 in in IN cord-010119-t1x9gknd 5237 37 other other JJ cord-010119-t1x9gknd 5237 38 research research NN cord-010119-t1x9gknd 5237 39 projects project NNS cord-010119-t1x9gknd 5237 40 that that WDT cord-010119-t1x9gknd 5237 41 require require VBP cord-010119-t1x9gknd 5237 42 PBMCs pbmc NNS cord-010119-t1x9gknd 5237 43 from from IN cord-010119-t1x9gknd 5237 44 healthy healthy JJ cord-010119-t1x9gknd 5237 45 adults adult NNS cord-010119-t1x9gknd 5237 46 . . . cord-010119-t1x9gknd 5238 1 Background Background NNP cord-010119-t1x9gknd 5238 2 / / SYM cord-010119-t1x9gknd 5238 3 Case Case NNP cord-010119-t1x9gknd 5238 4 Studies Studies NNPS cord-010119-t1x9gknd 5238 5 : : : cord-010119-t1x9gknd 5238 6 The the DT cord-010119-t1x9gknd 5238 7 goal goal NN cord-010119-t1x9gknd 5238 8 of of IN cord-010119-t1x9gknd 5238 9 this this DT cord-010119-t1x9gknd 5238 10 presentation presentation NN cord-010119-t1x9gknd 5238 11 is be VBZ cord-010119-t1x9gknd 5238 12 to to TO cord-010119-t1x9gknd 5238 13 describe describe VB cord-010119-t1x9gknd 5238 14 the the DT cord-010119-t1x9gknd 5238 15 journey journey NN cord-010119-t1x9gknd 5238 16 and and CC cord-010119-t1x9gknd 5238 17 challenges challenge NNS cord-010119-t1x9gknd 5238 18 towards towards IN cord-010119-t1x9gknd 5238 19 TJC TJC NNP cord-010119-t1x9gknd 5238 20 , , , cord-010119-t1x9gknd 5238 21 Patient Patient NNP cord-010119-t1x9gknd 5238 22 Blood Blood NNP cord-010119-t1x9gknd 5238 23 Management Management NNP cord-010119-t1x9gknd 5238 24 ( ( -LRB- cord-010119-t1x9gknd 5238 25 PBM PBM NNP cord-010119-t1x9gknd 5238 26 ) ) -RRB- cord-010119-t1x9gknd 5238 27 Certification certification NN cord-010119-t1x9gknd 5238 28 . . . cord-010119-t1x9gknd 5239 1 Transfusion transfusion NN cord-010119-t1x9gknd 5239 2 - - HYPH cord-010119-t1x9gknd 5239 3 related relate VBN cord-010119-t1x9gknd 5239 4 health health NN cord-010119-t1x9gknd 5239 5 risks risk NNS cord-010119-t1x9gknd 5239 6 and and CC cord-010119-t1x9gknd 5239 7 increasing increase VBG cord-010119-t1x9gknd 5239 8 economic economic JJ cord-010119-t1x9gknd 5239 9 pressures pressure NNS cord-010119-t1x9gknd 5239 10 have have VBP cord-010119-t1x9gknd 5239 11 driven drive VBN cord-010119-t1x9gknd 5239 12 hospitals hospital NNS cord-010119-t1x9gknd 5239 13 to to TO cord-010119-t1x9gknd 5239 14 recognize recognize VB cord-010119-t1x9gknd 5239 15 evidence evidence NN cord-010119-t1x9gknd 5239 16 - - HYPH cord-010119-t1x9gknd 5239 17 based base VBN cord-010119-t1x9gknd 5239 18 blood blood NN cord-010119-t1x9gknd 5239 19 management management NN cord-010119-t1x9gknd 5239 20 as as IN cord-010119-t1x9gknd 5239 21 an an DT cord-010119-t1x9gknd 5239 22 important important JJ cord-010119-t1x9gknd 5239 23 cost cost NN cord-010119-t1x9gknd 5239 24 - - HYPH cord-010119-t1x9gknd 5239 25 saving save VBG cord-010119-t1x9gknd 5239 26 strategy strategy NN cord-010119-t1x9gknd 5239 27 . . . cord-010119-t1x9gknd 5240 1 Providence Providence NNP cord-010119-t1x9gknd 5240 2 Holy Holy NNP cord-010119-t1x9gknd 5240 3 Cross Cross NNP cord-010119-t1x9gknd 5240 4 Medical Medical NNP cord-010119-t1x9gknd 5240 5 Center Center NNP cord-010119-t1x9gknd 5240 6 ( ( -LRB- cord-010119-t1x9gknd 5240 7 PHCMC PHCMC NNP cord-010119-t1x9gknd 5240 8 ) ) -RRB- cord-010119-t1x9gknd 5240 9 , , , cord-010119-t1x9gknd 5240 10 as as IN cord-010119-t1x9gknd 5240 11 the the DT cord-010119-t1x9gknd 5240 12 Providence Providence NNP cord-010119-t1x9gknd 5240 13 California California NNP cord-010119-t1x9gknd 5240 14 Region Region NNP cord-010119-t1x9gknd 5240 15 alpha alpha NN cord-010119-t1x9gknd 5240 16 site site NN cord-010119-t1x9gknd 5240 17 , , , cord-010119-t1x9gknd 5240 18 has have VBZ cord-010119-t1x9gknd 5240 19 embarked embark VBN cord-010119-t1x9gknd 5240 20 on on IN cord-010119-t1x9gknd 5240 21 this this DT cord-010119-t1x9gknd 5240 22 journey journey NN cord-010119-t1x9gknd 5240 23 . . . cord-010119-t1x9gknd 5241 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5241 2 goals goal NNS cord-010119-t1x9gknd 5241 3 are be VBP cord-010119-t1x9gknd 5241 4 PBM PBM NNP cord-010119-t1x9gknd 5241 5 certification certification NN cord-010119-t1x9gknd 5241 6 and and CC cord-010119-t1x9gknd 5241 7 reduction reduction NN cord-010119-t1x9gknd 5241 8 of of IN cord-010119-t1x9gknd 5241 9 the the DT cord-010119-t1x9gknd 5241 10 number number NN cord-010119-t1x9gknd 5241 11 of of IN cord-010119-t1x9gknd 5241 12 unnecessary unnecessary JJ cord-010119-t1x9gknd 5241 13 transfusions transfusion NNS cord-010119-t1x9gknd 5241 14 by by IN cord-010119-t1x9gknd 5241 15 20 20 CD cord-010119-t1x9gknd 5241 16 % % NN cord-010119-t1x9gknd 5241 17 within within IN cord-010119-t1x9gknd 5241 18 12 12 CD cord-010119-t1x9gknd 5241 19 months month NNS cord-010119-t1x9gknd 5241 20 of of IN cord-010119-t1x9gknd 5241 21 the the DT cord-010119-t1x9gknd 5241 22 program program NN cord-010119-t1x9gknd 5241 23 launch launch NN cord-010119-t1x9gknd 5241 24 while while IN cord-010119-t1x9gknd 5241 25 improving improve VBG cord-010119-t1x9gknd 5241 26 patient patient JJ cord-010119-t1x9gknd 5241 27 outcomes outcome NNS cord-010119-t1x9gknd 5241 28 . . . cord-010119-t1x9gknd 5242 1 This this DT cord-010119-t1x9gknd 5242 2 paper paper NN cord-010119-t1x9gknd 5242 3 will will MD cord-010119-t1x9gknd 5242 4 discuss discuss VB cord-010119-t1x9gknd 5242 5 our -PRON- PRP$ cord-010119-t1x9gknd 5242 6 journey journey NN cord-010119-t1x9gknd 5242 7 toward toward IN cord-010119-t1x9gknd 5242 8 certification certification NN cord-010119-t1x9gknd 5242 9 and and CC cord-010119-t1x9gknd 5242 10 the the DT cord-010119-t1x9gknd 5242 11 various various JJ cord-010119-t1x9gknd 5242 12 hurdles hurdle NNS cord-010119-t1x9gknd 5242 13 being be VBG cord-010119-t1x9gknd 5242 14 overcome overcome VBN cord-010119-t1x9gknd 5242 15 . . . cord-010119-t1x9gknd 5243 1 Study Study NNP cord-010119-t1x9gknd 5243 2 Design Design NNP cord-010119-t1x9gknd 5243 3 / / SYM cord-010119-t1x9gknd 5243 4 Method method NN cord-010119-t1x9gknd 5243 5 : : : cord-010119-t1x9gknd 5243 6 TJC TJC NNP cord-010119-t1x9gknd 5243 7 , , , cord-010119-t1x9gknd 5243 8 AABB AABB NNP cord-010119-t1x9gknd 5243 9 , , , cord-010119-t1x9gknd 5243 10 and and CC cord-010119-t1x9gknd 5243 11 the the DT cord-010119-t1x9gknd 5243 12 Society Society NNP cord-010119-t1x9gknd 5243 13 for for IN cord-010119-t1x9gknd 5243 14 the the DT cord-010119-t1x9gknd 5243 15 Advancement Advancement NNP cord-010119-t1x9gknd 5243 16 of of IN cord-010119-t1x9gknd 5243 17 Blood Blood NNP cord-010119-t1x9gknd 5243 18 Management Management NNP cord-010119-t1x9gknd 5243 19 have have VBP cord-010119-t1x9gknd 5243 20 served serve VBN cord-010119-t1x9gknd 5243 21 as as IN cord-010119-t1x9gknd 5243 22 our -PRON- PRP$ cord-010119-t1x9gknd 5243 23 primary primary JJ cord-010119-t1x9gknd 5243 24 resources resource NNS cord-010119-t1x9gknd 5243 25 for for IN cord-010119-t1x9gknd 5243 26 identifying identify VBG cord-010119-t1x9gknd 5243 27 current current JJ cord-010119-t1x9gknd 5243 28 evidence evidence NN cord-010119-t1x9gknd 5243 29 - - HYPH cord-010119-t1x9gknd 5243 30 based base VBN cord-010119-t1x9gknd 5243 31 transfusion transfusion NN cord-010119-t1x9gknd 5243 32 practices practice NNS cord-010119-t1x9gknd 5243 33 and and CC cord-010119-t1x9gknd 5243 34 management management NN cord-010119-t1x9gknd 5243 35 methods method NNS cord-010119-t1x9gknd 5243 36 . . . cord-010119-t1x9gknd 5244 1 We -PRON- PRP cord-010119-t1x9gknd 5244 2 needed need VBD cord-010119-t1x9gknd 5244 3 to to TO cord-010119-t1x9gknd 5244 4 identify identify VB cord-010119-t1x9gknd 5244 5 our -PRON- PRP$ cord-010119-t1x9gknd 5244 6 organizational organizational JJ cord-010119-t1x9gknd 5244 7 gaps gap NNS cord-010119-t1x9gknd 5244 8 in in IN cord-010119-t1x9gknd 5244 9 data datum NNS cord-010119-t1x9gknd 5244 10 gathering gathering NN cord-010119-t1x9gknd 5244 11 and and CC cord-010119-t1x9gknd 5244 12 analysis analysis NN cord-010119-t1x9gknd 5244 13 . . . cord-010119-t1x9gknd 5245 1 Then then RB cord-010119-t1x9gknd 5245 2 we -PRON- PRP cord-010119-t1x9gknd 5245 3 could could MD cord-010119-t1x9gknd 5245 4 determine determine VB cord-010119-t1x9gknd 5245 5 baseline baseline JJ cord-010119-t1x9gknd 5245 6 performance performance NN cord-010119-t1x9gknd 5245 7 and and CC cord-010119-t1x9gknd 5245 8 set set VBN cord-010119-t1x9gknd 5245 9 improvement improvement NN cord-010119-t1x9gknd 5245 10 targets target NNS cord-010119-t1x9gknd 5245 11 . . . cord-010119-t1x9gknd 5246 1 From from IN cord-010119-t1x9gknd 5246 2 our -PRON- PRP$ cord-010119-t1x9gknd 5246 3 internal internal JJ cord-010119-t1x9gknd 5246 4 assessment assessment NN cord-010119-t1x9gknd 5246 5 , , , cord-010119-t1x9gknd 5246 6 we -PRON- PRP cord-010119-t1x9gknd 5246 7 learned learn VBD cord-010119-t1x9gknd 5246 8 we -PRON- PRP cord-010119-t1x9gknd 5246 9 had have VBD cord-010119-t1x9gknd 5246 10 to to TO cord-010119-t1x9gknd 5246 11 start start VB cord-010119-t1x9gknd 5246 12 from from IN cord-010119-t1x9gknd 5246 13 scratch scratch NN cord-010119-t1x9gknd 5246 14 as as IN cord-010119-t1x9gknd 5246 15 we -PRON- PRP cord-010119-t1x9gknd 5246 16 had have VBD cord-010119-t1x9gknd 5246 17 no no DT cord-010119-t1x9gknd 5246 18 easily easily RB cord-010119-t1x9gknd 5246 19 accessible accessible JJ cord-010119-t1x9gknd 5246 20 data data NN cord-010119-t1x9gknd 5246 21 metrics metric NNS cord-010119-t1x9gknd 5246 22 and and CC cord-010119-t1x9gknd 5246 23 gaps gap NNS cord-010119-t1x9gknd 5246 24 in in IN cord-010119-t1x9gknd 5246 25 education education NN cord-010119-t1x9gknd 5246 26 to to IN cord-010119-t1x9gknd 5246 27 our -PRON- PRP$ cord-010119-t1x9gknd 5246 28 staff staff NN cord-010119-t1x9gknd 5246 29 . . . cord-010119-t1x9gknd 5247 1 We -PRON- PRP cord-010119-t1x9gknd 5247 2 took take VBD cord-010119-t1x9gknd 5247 3 the the DT cord-010119-t1x9gknd 5247 4 following follow VBG cord-010119-t1x9gknd 5247 5 steps step NNS cord-010119-t1x9gknd 5247 6 to to TO cord-010119-t1x9gknd 5247 7 develop develop VB cord-010119-t1x9gknd 5247 8 our -PRON- PRP$ cord-010119-t1x9gknd 5247 9 PBM PBM NNP cord-010119-t1x9gknd 5247 10 program program NN cord-010119-t1x9gknd 5247 11 : : : cord-010119-t1x9gknd 5248 1 Formed form VBN cord-010119-t1x9gknd 5248 2 an an DT cord-010119-t1x9gknd 5248 3 interdisciplinary interdisciplinary JJ cord-010119-t1x9gknd 5248 4 PBM PBM NNP cord-010119-t1x9gknd 5248 5 team team NN cord-010119-t1x9gknd 5248 6 consisting consist VBG cord-010119-t1x9gknd 5248 7 of of IN cord-010119-t1x9gknd 5248 8 physicians physician NNS cord-010119-t1x9gknd 5248 9 , , , cord-010119-t1x9gknd 5248 10 nurses nurse NNS cord-010119-t1x9gknd 5248 11 , , , cord-010119-t1x9gknd 5248 12 blood blood NN cord-010119-t1x9gknd 5248 13 bank bank NN cord-010119-t1x9gknd 5248 14 staff staff NN cord-010119-t1x9gknd 5248 15 , , , cord-010119-t1x9gknd 5248 16 and and CC cord-010119-t1x9gknd 5248 17 data datum NNS cord-010119-t1x9gknd 5248 18 analysts analyst NNS cord-010119-t1x9gknd 5248 19 Constructed construct VBD cord-010119-t1x9gknd 5248 20 a a DT cord-010119-t1x9gknd 5248 21 report report NN cord-010119-t1x9gknd 5248 22 on on IN cord-010119-t1x9gknd 5248 23 RBC RBC NNP cord-010119-t1x9gknd 5248 24 transfusions transfusion NNS cord-010119-t1x9gknd 5248 25 to to TO cord-010119-t1x9gknd 5248 26 help help VB cord-010119-t1x9gknd 5248 27 identify identify VB cord-010119-t1x9gknd 5248 28 outliers outlier NNS cord-010119-t1x9gknd 5248 29 and and CC cord-010119-t1x9gknd 5248 30 opportunities opportunity NNS cord-010119-t1x9gknd 5248 31 Background Background NNP cord-010119-t1x9gknd 5248 32 / / SYM cord-010119-t1x9gknd 5248 33 Case Case NNP cord-010119-t1x9gknd 5248 34 Studies Studies NNPS cord-010119-t1x9gknd 5248 35 : : : cord-010119-t1x9gknd 5249 1 The the DT cord-010119-t1x9gknd 5249 2 maximum maximum JJ cord-010119-t1x9gknd 5249 3 surgical surgical JJ cord-010119-t1x9gknd 5249 4 blood blood NN cord-010119-t1x9gknd 5249 5 ordering ordering NN cord-010119-t1x9gknd 5249 6 schedule schedule NN cord-010119-t1x9gknd 5249 7 ( ( -LRB- cord-010119-t1x9gknd 5249 8 MSBOS MSBOS NNP cord-010119-t1x9gknd 5249 9 ) ) -RRB- cord-010119-t1x9gknd 5249 10 is be VBZ cord-010119-t1x9gknd 5249 11 a a DT cord-010119-t1x9gknd 5249 12 list list NN cord-010119-t1x9gknd 5249 13 of of IN cord-010119-t1x9gknd 5249 14 surgical surgical JJ cord-010119-t1x9gknd 5249 15 procedures procedure NNS cord-010119-t1x9gknd 5249 16 performed perform VBN cord-010119-t1x9gknd 5249 17 at at IN cord-010119-t1x9gknd 5249 18 a a DT cord-010119-t1x9gknd 5249 19 hospital hospital NN cord-010119-t1x9gknd 5249 20 along along IN cord-010119-t1x9gknd 5249 21 with with IN cord-010119-t1x9gknd 5249 22 a a DT cord-010119-t1x9gknd 5249 23 recommendation recommendation NN cord-010119-t1x9gknd 5249 24 for for IN cord-010119-t1x9gknd 5249 25 pre pre JJ cord-010119-t1x9gknd 5249 26 - - JJ cord-010119-t1x9gknd 5249 27 transfusion transfusion JJ cord-010119-t1x9gknd 5249 28 testing testing NN cord-010119-t1x9gknd 5249 29 and and CC cord-010119-t1x9gknd 5249 30 RBC RBC NNP cord-010119-t1x9gknd 5249 31 allocation allocation NN cord-010119-t1x9gknd 5249 32 before before IN cord-010119-t1x9gknd 5249 33 each each DT cord-010119-t1x9gknd 5249 34 surgery surgery NN cord-010119-t1x9gknd 5249 35 . . . cord-010119-t1x9gknd 5250 1 The the DT cord-010119-t1x9gknd 5250 2 extent extent NN cord-010119-t1x9gknd 5250 3 to to TO cord-010119-t1x9gknd 5250 4 which which WDT cord-010119-t1x9gknd 5250 5 hospitals hospital NNS cord-010119-t1x9gknd 5250 6 have have VBP cord-010119-t1x9gknd 5250 7 an an DT cord-010119-t1x9gknd 5250 8 MSBOS msbo NNS cord-010119-t1x9gknd 5250 9 and and CC cord-010119-t1x9gknd 5250 10 its -PRON- PRP$ cord-010119-t1x9gknd 5250 11 design design NN cord-010119-t1x9gknd 5250 12 was be VBD cord-010119-t1x9gknd 5250 13 explored explore VBN cord-010119-t1x9gknd 5250 14 in in IN cord-010119-t1x9gknd 5250 15 this this DT cord-010119-t1x9gknd 5250 16 survey survey NN cord-010119-t1x9gknd 5250 17 . . . cord-010119-t1x9gknd 5251 1 Study Study NNP cord-010119-t1x9gknd 5251 2 Design Design NNP cord-010119-t1x9gknd 5251 3 / / SYM cord-010119-t1x9gknd 5251 4 Methods method NNS cord-010119-t1x9gknd 5251 5 : : : cord-010119-t1x9gknd 5251 6 The the DT cord-010119-t1x9gknd 5251 7 survey survey NN cord-010119-t1x9gknd 5251 8 was be VBD cord-010119-t1x9gknd 5251 9 designed design VBN cord-010119-t1x9gknd 5251 10 , , , cord-010119-t1x9gknd 5251 11 piloted pilot VBN cord-010119-t1x9gknd 5251 12 and and CC cord-010119-t1x9gknd 5251 13 refined refine VBN cord-010119-t1x9gknd 5251 14 by by IN cord-010119-t1x9gknd 5251 15 members member NNS cord-010119-t1x9gknd 5251 16 of of IN cord-010119-t1x9gknd 5251 17 the the DT cord-010119-t1x9gknd 5251 18 BEST well RBS cord-010119-t1x9gknd 5251 19 collaborative collaborative NN cord-010119-t1x9gknd 5251 20 and and CC cord-010119-t1x9gknd 5251 21 invited invite VBN cord-010119-t1x9gknd 5251 22 colleagues colleague NNS cord-010119-t1x9gknd 5251 23 . . . cord-010119-t1x9gknd 5252 1 It -PRON- PRP cord-010119-t1x9gknd 5252 2 was be VBD cord-010119-t1x9gknd 5252 3 then then RB cord-010119-t1x9gknd 5252 4 encoded encode VBN cord-010119-t1x9gknd 5252 5 in in IN cord-010119-t1x9gknd 5252 6 online online JJ cord-010119-t1x9gknd 5252 7 survey survey NN cord-010119-t1x9gknd 5252 8 software software NN cord-010119-t1x9gknd 5252 9 and and CC cord-010119-t1x9gknd 5252 10 the the DT cord-010119-t1x9gknd 5252 11 link link NN cord-010119-t1x9gknd 5252 12 distributed distribute VBN cord-010119-t1x9gknd 5252 13 to to IN cord-010119-t1x9gknd 5252 14 BEST best JJ cord-010119-t1x9gknd 5252 15 members member NNS cord-010119-t1x9gknd 5252 16 and and CC cord-010119-t1x9gknd 5252 17 colleagues colleague NNS cord-010119-t1x9gknd 5252 18 who who WP cord-010119-t1x9gknd 5252 19 were be VBD cord-010119-t1x9gknd 5252 20 encouraged encourage VBN cord-010119-t1x9gknd 5252 21 to to TO cord-010119-t1x9gknd 5252 22 respond respond VB cord-010119-t1x9gknd 5252 23 and and CC cord-010119-t1x9gknd 5252 24 to to TO cord-010119-t1x9gknd 5252 25 further further RB cord-010119-t1x9gknd 5252 26 distribute distribute VB cord-010119-t1x9gknd 5252 27 it -PRON- PRP cord-010119-t1x9gknd 5252 28 . . . cord-010119-t1x9gknd 5253 1 The the DT cord-010119-t1x9gknd 5253 2 survey survey NN cord-010119-t1x9gknd 5253 3 was be VBD cord-010119-t1x9gknd 5253 4 open open JJ cord-010119-t1x9gknd 5253 5 for for IN cord-010119-t1x9gknd 5253 6 34 34 CD cord-010119-t1x9gknd 5253 7 days day NNS cord-010119-t1x9gknd 5253 8 . . . cord-010119-t1x9gknd 5254 1 Results result NNS cord-010119-t1x9gknd 5254 2 / / SYM cord-010119-t1x9gknd 5254 3 Findings finding NNS cord-010119-t1x9gknd 5255 1 : : : cord-010119-t1x9gknd 5255 2 There there EX cord-010119-t1x9gknd 5255 3 were be VBD cord-010119-t1x9gknd 5255 4 158 158 CD cord-010119-t1x9gknd 5255 5 completed complete VBN cord-010119-t1x9gknd 5255 6 responses response NNS cord-010119-t1x9gknd 5255 7 , , , cord-010119-t1x9gknd 5255 8 of of IN cord-010119-t1x9gknd 5255 9 which which WDT cord-010119-t1x9gknd 5255 10 73 73 CD cord-010119-t1x9gknd 5255 11 ( ( -LRB- cord-010119-t1x9gknd 5255 12 46 46 CD cord-010119-t1x9gknd 5255 13 % % NN cord-010119-t1x9gknd 5255 14 ) ) -RRB- cord-010119-t1x9gknd 5255 15 indicated indicate VBD cord-010119-t1x9gknd 5255 16 that that IN cord-010119-t1x9gknd 5255 17 their -PRON- PRP$ cord-010119-t1x9gknd 5255 18 hospital hospital NN cord-010119-t1x9gknd 5255 19 had have VBD cord-010119-t1x9gknd 5255 20 an an DT cord-010119-t1x9gknd 5255 21 MSBOS MSBOS NNP cord-010119-t1x9gknd 5255 22 and and CC cord-010119-t1x9gknd 5255 23 85 85 CD cord-010119-t1x9gknd 5255 24 ( ( -LRB- cord-010119-t1x9gknd 5255 25 54 54 CD cord-010119-t1x9gknd 5255 26 % % NN cord-010119-t1x9gknd 5255 27 ) ) -RRB- cord-010119-t1x9gknd 5256 1 did do VBD cord-010119-t1x9gknd 5256 2 not not RB cord-010119-t1x9gknd 5256 3 . . . cord-010119-t1x9gknd 5257 1 The the DT cord-010119-t1x9gknd 5257 2 majority majority NN cord-010119-t1x9gknd 5257 3 of of IN cord-010119-t1x9gknd 5257 4 hospitals hospital NNS cord-010119-t1x9gknd 5257 5 without without IN cord-010119-t1x9gknd 5257 6 an an DT cord-010119-t1x9gknd 5257 7 MSBOS msbo NNS cord-010119-t1x9gknd 5257 8 were be VBD cord-010119-t1x9gknd 5257 9 academic academic JJ cord-010119-t1x9gknd 5257 10 centers center NNS cord-010119-t1x9gknd 5257 11 ( ( -LRB- cord-010119-t1x9gknd 5257 12 36/85 36/85 CD cord-010119-t1x9gknd 5257 13 , , , cord-010119-t1x9gknd 5257 14 42 42 CD cord-010119-t1x9gknd 5257 15 % % NN cord-010119-t1x9gknd 5257 16 ) ) -RRB- cord-010119-t1x9gknd 5257 17 from from IN cord-010119-t1x9gknd 5257 18 Oceania Oceania NNP cord-010119-t1x9gknd 5257 19 ( ( -LRB- cord-010119-t1x9gknd 5257 20 26/85 26/85 CD cord-010119-t1x9gknd 5257 21 , , , cord-010119-t1x9gknd 5257 22 31 31 CD cord-010119-t1x9gknd 5257 23 % % NN cord-010119-t1x9gknd 5257 24 ) ) -RRB- cord-010119-t1x9gknd 5257 25 or or CC cord-010119-t1x9gknd 5257 26 Europe Europe NNP cord-010119-t1x9gknd 5257 27 ( ( -LRB- cord-010119-t1x9gknd 5257 28 23/85 23/85 CD cord-010119-t1x9gknd 5257 29 , , , cord-010119-t1x9gknd 5257 30 27 27 CD cord-010119-t1x9gknd 5257 31 % % NN cord-010119-t1x9gknd 5257 32 ) ) -RRB- cord-010119-t1x9gknd 5257 33 , , , cord-010119-t1x9gknd 5257 34 had have VBD cord-010119-t1x9gknd 5257 35 between between IN cord-010119-t1x9gknd 5257 36 500 500 CD cord-010119-t1x9gknd 5257 37 - - SYM cord-010119-t1x9gknd 5257 38 999 999 CD cord-010119-t1x9gknd 5257 39 beds bed NNS cord-010119-t1x9gknd 5257 40 ( ( -LRB- cord-010119-t1x9gknd 5257 41 30/85 30/85 CD cord-010119-t1x9gknd 5257 42 , , , cord-010119-t1x9gknd 5257 43 35 35 CD cord-010119-t1x9gknd 5257 44 % % NN cord-010119-t1x9gknd 5257 45 ) ) -RRB- cord-010119-t1x9gknd 5257 46 ; ; : cord-010119-t1x9gknd 5257 47 the the DT cord-010119-t1x9gknd 5257 48 majority majority NN cord-010119-t1x9gknd 5257 49 of of IN cord-010119-t1x9gknd 5257 50 these these DT cord-010119-t1x9gknd 5257 51 hospitals hospital NNS cord-010119-t1x9gknd 5257 52 transfused transfuse VBN cord-010119-t1x9gknd 5257 53 between between IN cord-010119-t1x9gknd 5257 54 1,001 1,001 CD cord-010119-t1x9gknd 5257 55 - - SYM cord-010119-t1x9gknd 5257 56 4,999 4,999 CD cord-010119-t1x9gknd 5257 57 RBCs rbc NNS cord-010119-t1x9gknd 5257 58 ( ( -LRB- cord-010119-t1x9gknd 5257 59 21/85 21/85 CD cord-010119-t1x9gknd 5257 60 , , , cord-010119-t1x9gknd 5257 61 25 25 CD cord-010119-t1x9gknd 5257 62 % % NN cord-010119-t1x9gknd 5257 63 ) ) -RRB- cord-010119-t1x9gknd 5257 64 per per IN cord-010119-t1x9gknd 5257 65 year year NN cord-010119-t1x9gknd 5257 66 . . . cord-010119-t1x9gknd 5258 1 15/85 15/85 LS cord-010119-t1x9gknd 5258 2 ( ( -LRB- cord-010119-t1x9gknd 5258 3 18 18 CD cord-010119-t1x9gknd 5258 4 % % NN cord-010119-t1x9gknd 5258 5 ) ) -RRB- cord-010119-t1x9gknd 5258 6 are be VBP cord-010119-t1x9gknd 5258 7 going go VBG cord-010119-t1x9gknd 5258 8 to to TO cord-010119-t1x9gknd 5258 9 implement implement VB cord-010119-t1x9gknd 5258 10 an an DT cord-010119-t1x9gknd 5258 11 MSBOS MSBOS NNP cord-010119-t1x9gknd 5258 12 in in IN cord-010119-t1x9gknd 5258 13 2017 2017 CD cord-010119-t1x9gknd 5258 14 . . . cord-010119-t1x9gknd 5259 1 Of of IN cord-010119-t1x9gknd 5259 2 those those DT cord-010119-t1x9gknd 5259 3 with with IN cord-010119-t1x9gknd 5259 4 an an DT cord-010119-t1x9gknd 5259 5 MSBOS MSBOS NNPS cord-010119-t1x9gknd 5259 6 , , , cord-010119-t1x9gknd 5259 7 the the DT cord-010119-t1x9gknd 5259 8 majority majority NN cord-010119-t1x9gknd 5259 9 23/73 23/73 CD cord-010119-t1x9gknd 5259 10 ( ( -LRB- cord-010119-t1x9gknd 5259 11 32 32 CD cord-010119-t1x9gknd 5259 12 % % NN cord-010119-t1x9gknd 5259 13 ) ) -RRB- cord-010119-t1x9gknd 5259 14 were be VBD cord-010119-t1x9gknd 5259 15 from from IN cord-010119-t1x9gknd 5259 16 North North NNP cord-010119-t1x9gknd 5259 17 America America NNP cord-010119-t1x9gknd 5259 18 . . . cord-010119-t1x9gknd 5260 1 The the DT cord-010119-t1x9gknd 5260 2 majority majority NN cord-010119-t1x9gknd 5260 3 were be VBD cord-010119-t1x9gknd 5260 4 academic academic JJ cord-010119-t1x9gknd 5260 5 hospitals hospital NNS cord-010119-t1x9gknd 5260 6 ( ( -LRB- cord-010119-t1x9gknd 5260 7 39/ 39/ CD cord-010119-t1x9gknd 5260 8 73 73 CD cord-010119-t1x9gknd 5260 9 , , , cord-010119-t1x9gknd 5260 10 53 53 CD cord-010119-t1x9gknd 5260 11 % % NN cord-010119-t1x9gknd 5260 12 ) ) -RRB- cord-010119-t1x9gknd 5260 13 with with IN cord-010119-t1x9gknd 5260 14 500 500 CD cord-010119-t1x9gknd 5260 15 - - SYM cord-010119-t1x9gknd 5260 16 999 999 CD cord-010119-t1x9gknd 5260 17 beds bed NNS cord-010119-t1x9gknd 5260 18 ( ( -LRB- cord-010119-t1x9gknd 5260 19 43/73 43/73 CD cord-010119-t1x9gknd 5260 20 , , , cord-010119-t1x9gknd 5260 21 59 59 CD cord-010119-t1x9gknd 5260 22 % % NN cord-010119-t1x9gknd 5260 23 ) ) -RRB- cord-010119-t1x9gknd 5260 24 that that WDT cord-010119-t1x9gknd 5260 25 transfused transfuse VBN cord-010119-t1x9gknd 5260 26 ! ! . cord-010119-t1x9gknd 5261 1 20,000 20,000 CD cord-010119-t1x9gknd 5261 2 RBC RBC NNP cord-010119-t1x9gknd 5261 3 units unit NNS cord-010119-t1x9gknd 5261 4 per per IN cord-010119-t1x9gknd 5261 5 year year NN cord-010119-t1x9gknd 5261 6 ( ( -LRB- cord-010119-t1x9gknd 5261 7 21/73 21/73 CD cord-010119-t1x9gknd 5261 8 , , , cord-010119-t1x9gknd 5261 9 29 29 CD cord-010119-t1x9gknd 5261 10 % % NN cord-010119-t1x9gknd 5261 11 ) ) -RRB- cord-010119-t1x9gknd 5261 12 offering offer VBG cord-010119-t1x9gknd 5261 13 a a DT cord-010119-t1x9gknd 5261 14 wide wide JJ cord-010119-t1x9gknd 5261 15 range range NN cord-010119-t1x9gknd 5261 16 of of IN cord-010119-t1x9gknd 5261 17 surgical surgical JJ cord-010119-t1x9gknd 5261 18 services service NNS cord-010119-t1x9gknd 5261 19 . . . cord-010119-t1x9gknd 5262 1 On on IN cord-010119-t1x9gknd 5262 2 average average JJ cord-010119-t1x9gknd 5262 3 there there EX cord-010119-t1x9gknd 5262 4 were be VBD cord-010119-t1x9gknd 5262 5 207 207 CD cord-010119-t1x9gknd 5262 6 6 6 CD cord-010119-t1x9gknd 5262 7 577 577 CD cord-010119-t1x9gknd 5262 8 procedures procedure NNS cord-010119-t1x9gknd 5262 9 listed list VBN cord-010119-t1x9gknd 5262 10 in in IN cord-010119-t1x9gknd 5262 11 the the DT cord-010119-t1x9gknd 5262 12 MSBOS MSBOS NNP cord-010119-t1x9gknd 5262 13 ' ' '' cord-010119-t1x9gknd 5262 14 . . . cord-010119-t1x9gknd 5263 1 The the DT cord-010119-t1x9gknd 5263 2 MSBOS MSBOS NNPS cord-010119-t1x9gknd 5263 3 recommended recommend VBD cord-010119-t1x9gknd 5263 4 no no DT cord-010119-t1x9gknd 5263 5 pre pre JJ cord-010119-t1x9gknd 5263 6 - - JJ cord-010119-t1x9gknd 5263 7 transfusion transfusion JJ cord-010119-t1x9gknd 5263 8 testing testing NN cord-010119-t1x9gknd 5263 9 for for IN cord-010119-t1x9gknd 5263 10 a a DT cord-010119-t1x9gknd 5263 11 mean mean NN cord-010119-t1x9gknd 5263 12 of of IN cord-010119-t1x9gknd 5263 13 30 30 CD cord-010119-t1x9gknd 5263 14 % % NN cord-010119-t1x9gknd 5263 15 of of IN cord-010119-t1x9gknd 5263 16 the the DT cord-010119-t1x9gknd 5263 17 procedures procedure NNS cord-010119-t1x9gknd 5263 18 listed list VBN cord-010119-t1x9gknd 5263 19 , , , cord-010119-t1x9gknd 5263 20 a a DT cord-010119-t1x9gknd 5263 21 pre pre JJ cord-010119-t1x9gknd 5263 22 - - JJ cord-010119-t1x9gknd 5263 23 operative operative JJ cord-010119-t1x9gknd 5263 24 type type NN cord-010119-t1x9gknd 5263 25 and and CC cord-010119-t1x9gknd 5263 26 screen screen NN cord-010119-t1x9gknd 5263 27 for for IN cord-010119-t1x9gknd 5263 28 38 38 CD cord-010119-t1x9gknd 5263 29 % % NN cord-010119-t1x9gknd 5263 30 , , , cord-010119-t1x9gknd 5263 31 crossmatching crossmatche VBG cord-010119-t1x9gknd 5263 32 RBC RBC NNP cord-010119-t1x9gknd 5263 33 units unit NNS cord-010119-t1x9gknd 5263 34 for for IN cord-010119-t1x9gknd 5263 35 28 28 CD cord-010119-t1x9gknd 5263 36 % % NN cord-010119-t1x9gknd 5263 37 , , , cord-010119-t1x9gknd 5263 38 and and CC cord-010119-t1x9gknd 5263 39 for for IN cord-010119-t1x9gknd 5263 40 4 4 CD cord-010119-t1x9gknd 5263 41 % % NN cord-010119-t1x9gknd 5263 42 of of IN cord-010119-t1x9gknd 5263 43 procedures procedure NNS cord-010119-t1x9gknd 5263 44 a a DT cord-010119-t1x9gknd 5263 45 different different JJ cord-010119-t1x9gknd 5263 46 recommendation recommendation NN cord-010119-t1x9gknd 5263 47 was be VBD cord-010119-t1x9gknd 5263 48 made make VBN cord-010119-t1x9gknd 5263 49 . . . cord-010119-t1x9gknd 5264 1 Most Most JJS cord-010119-t1x9gknd 5264 2 ( ( -LRB- cord-010119-t1x9gknd 5264 3 32/73 32/73 CD cord-010119-t1x9gknd 5264 4 , , , cord-010119-t1x9gknd 5264 5 44 44 CD cord-010119-t1x9gknd 5264 6 % % NN cord-010119-t1x9gknd 5264 7 ) ) -RRB- cord-010119-t1x9gknd 5264 8 of of IN cord-010119-t1x9gknd 5264 9 the the DT cord-010119-t1x9gknd 5264 10 MSBOS MSBOS NNPS cord-010119-t1x9gknd 5264 11 ' ' POS cord-010119-t1x9gknd 5264 12 were be VBD cord-010119-t1x9gknd 5264 13 created create VBN cord-010119-t1x9gknd 5264 14 by by IN cord-010119-t1x9gknd 5264 15 a a DT cord-010119-t1x9gknd 5264 16 combination combination NN cord-010119-t1x9gknd 5264 17 of of IN cord-010119-t1x9gknd 5264 18 obtaining obtain VBG cord-010119-t1x9gknd 5264 19 consensus consensus NN cord-010119-t1x9gknd 5264 20 between between IN cord-010119-t1x9gknd 5264 21 the the DT cord-010119-t1x9gknd 5264 22 surgical surgical JJ cord-010119-t1x9gknd 5264 23 services service NNS cord-010119-t1x9gknd 5264 24 and and CC cord-010119-t1x9gknd 5264 25 blood blood NN cord-010119-t1x9gknd 5264 26 bank bank NN cord-010119-t1x9gknd 5264 27 and and CC cord-010119-t1x9gknd 5264 28 use use NN cord-010119-t1x9gknd 5264 29 of of IN cord-010119-t1x9gknd 5264 30 procedure procedure NN cord-010119-t1x9gknd 5264 31 - - HYPH cord-010119-t1x9gknd 5264 32 specific specific JJ cord-010119-t1x9gknd 5264 33 transfusion transfusion NN cord-010119-t1x9gknd 5264 34 data datum NNS cord-010119-t1x9gknd 5264 35 ; ; : cord-010119-t1x9gknd 5264 36 only only RB cord-010119-t1x9gknd 5264 37 5/73 5/73 CD cord-010119-t1x9gknd 5264 38 ( ( -LRB- cord-010119-t1x9gknd 5264 39 7 7 CD cord-010119-t1x9gknd 5264 40 % % NN cord-010119-t1x9gknd 5264 41 ) ) -RRB- cord-010119-t1x9gknd 5264 42 of of IN cord-010119-t1x9gknd 5264 43 MSBOS MSBOS NNP cord-010119-t1x9gknd 5264 44 ' ' POS cord-010119-t1x9gknd 5264 45 were be VBD cord-010119-t1x9gknd 5264 46 created create VBN cord-010119-t1x9gknd 5264 47 solely solely RB cord-010119-t1x9gknd 5264 48 by by IN cord-010119-t1x9gknd 5264 49 using use VBG cord-010119-t1x9gknd 5264 50 procedure procedure NN cord-010119-t1x9gknd 5264 51 - - HYPH cord-010119-t1x9gknd 5264 52 specific specific JJ cord-010119-t1x9gknd 5264 53 data datum NNS cord-010119-t1x9gknd 5264 54 , , , cord-010119-t1x9gknd 5264 55 and and CC cord-010119-t1x9gknd 5264 56 most most JJS cord-010119-t1x9gknd 5264 57 ( ( -LRB- cord-010119-t1x9gknd 5264 58 35/73 35/73 CD cord-010119-t1x9gknd 5264 59 , , , cord-010119-t1x9gknd 5264 60 48 48 CD cord-010119-t1x9gknd 5264 61 % % NN cord-010119-t1x9gknd 5264 62 ) ) -RRB- cord-010119-t1x9gknd 5264 63 do do VBP cord-010119-t1x9gknd 5264 64 not not RB cord-010119-t1x9gknd 5264 65 use use VB cord-010119-t1x9gknd 5264 66 patient patient NN cord-010119-t1x9gknd 5264 67 - - HYPH cord-010119-t1x9gknd 5264 68 specific specific JJ cord-010119-t1x9gknd 5264 69 data datum NNS cord-010119-t1x9gknd 5264 70 in in IN cord-010119-t1x9gknd 5264 71 making make VBG cord-010119-t1x9gknd 5264 72 a a DT cord-010119-t1x9gknd 5264 73 testing testing NN cord-010119-t1x9gknd 5264 74 recommendation recommendation NN cord-010119-t1x9gknd 5264 75 . . . cord-010119-t1x9gknd 5265 1 Most Most JJS cord-010119-t1x9gknd 5265 2 MSBOS msbo NNS cord-010119-t1x9gknd 5265 3 ' ' POS cord-010119-t1x9gknd 5265 4 are be VBP cord-010119-t1x9gknd 5265 5 updated update VBN cord-010119-t1x9gknd 5265 6 less less RBR cord-010119-t1x9gknd 5265 7 frequently frequently RB cord-010119-t1x9gknd 5265 8 than than IN cord-010119-t1x9gknd 5265 9 annually annually RB cord-010119-t1x9gknd 5265 10 ( ( -LRB- cord-010119-t1x9gknd 5265 11 30/73 30/73 CD cord-010119-t1x9gknd 5265 12 , , , cord-010119-t1x9gknd 5265 13 41 41 CD cord-010119-t1x9gknd 5265 14 % % NN cord-010119-t1x9gknd 5265 15 ) ) -RRB- cord-010119-t1x9gknd 5265 16 , , , cord-010119-t1x9gknd 5265 17 and and CC cord-010119-t1x9gknd 5265 18 the the DT cord-010119-t1x9gknd 5265 19 hospital hospital NN cord-010119-t1x9gknd 5265 20 transfusion transfusion NN cord-010119-t1x9gknd 5265 21 committee committee NN cord-010119-t1x9gknd 5265 22 is be VBZ cord-010119-t1x9gknd 5265 23 often often RB cord-010119-t1x9gknd 5265 24 ( ( -LRB- cord-010119-t1x9gknd 5265 25 39/73 39/73 CD cord-010119-t1x9gknd 5265 26 , , , cord-010119-t1x9gknd 5265 27 53 53 CD cord-010119-t1x9gknd 5265 28 % % NN cord-010119-t1x9gknd 5265 29 ) ) -RRB- cord-010119-t1x9gknd 5265 30 involved involve VBN cord-010119-t1x9gknd 5265 31 in in IN cord-010119-t1x9gknd 5265 32 updating update VBG cord-010119-t1x9gknd 5265 33 it -PRON- PRP cord-010119-t1x9gknd 5265 34 . . . cord-010119-t1x9gknd 5266 1 The the DT cord-010119-t1x9gknd 5266 2 MSBOS msbo NNS cord-010119-t1x9gknd 5266 3 ' ' POS cord-010119-t1x9gknd 5266 4 are be VBP cord-010119-t1x9gknd 5266 5 generally generally RB cord-010119-t1x9gknd 5266 6 available available JJ cord-010119-t1x9gknd 5266 7 electronically electronically RB cord-010119-t1x9gknd 5266 8 in in IN cord-010119-t1x9gknd 5266 9 both both CC cord-010119-t1x9gknd 5266 10 the the DT cord-010119-t1x9gknd 5266 11 operating operate VBG cord-010119-t1x9gknd 5266 12 rooms room NNS cord-010119-t1x9gknd 5266 13 and and CC cord-010119-t1x9gknd 5266 14 in in IN cord-010119-t1x9gknd 5266 15 the the DT cord-010119-t1x9gknd 5266 16 blood blood NN cord-010119-t1x9gknd 5266 17 banks bank NNS cord-010119-t1x9gknd 5266 18 . . . cord-010119-t1x9gknd 5267 1 It -PRON- PRP cord-010119-t1x9gknd 5267 2 was be VBD cord-010119-t1x9gknd 5267 3 the the DT cord-010119-t1x9gknd 5267 4 opinion opinion NN cord-010119-t1x9gknd 5267 5 of of IN cord-010119-t1x9gknd 5267 6 the the DT cord-010119-t1x9gknd 5267 7 majority majority NN cord-010119-t1x9gknd 5267 8 of of IN cord-010119-t1x9gknd 5267 9 respondents respondent NNS cord-010119-t1x9gknd 5267 10 ( ( -LRB- cord-010119-t1x9gknd 5267 11 30 30 CD cord-010119-t1x9gknd 5267 12 % % NN cord-010119-t1x9gknd 5267 13 ) ) -RRB- cord-010119-t1x9gknd 5267 14 that that IN cord-010119-t1x9gknd 5267 15 the the DT cord-010119-t1x9gknd 5267 16 MSBOS MSBOS NNP cord-010119-t1x9gknd 5267 17 was be VBD cord-010119-t1x9gknd 5267 18 used use VBN cord-010119-t1x9gknd 5267 19 regularly regularly RB cord-010119-t1x9gknd 5267 20 by by IN cord-010119-t1x9gknd 5267 21 only only RB cord-010119-t1x9gknd 5267 22 a a DT cord-010119-t1x9gknd 5267 23 limited limited JJ cord-010119-t1x9gknd 5267 24 number number NN cord-010119-t1x9gknd 5267 25 of of IN cord-010119-t1x9gknd 5267 26 surgeons surgeon NNS cord-010119-t1x9gknd 5267 27 and and CC cord-010119-t1x9gknd 5267 28 anesthesiologists anesthesiologist NNS cord-010119-t1x9gknd 5267 29 , , , cord-010119-t1x9gknd 5267 30 23 23 CD cord-010119-t1x9gknd 5267 31 % % NN cord-010119-t1x9gknd 5267 32 of of IN cord-010119-t1x9gknd 5267 33 respondents respondent NNS cord-010119-t1x9gknd 5267 34 felt feel VBD cord-010119-t1x9gknd 5267 35 that that IN cord-010119-t1x9gknd 5267 36 it -PRON- PRP cord-010119-t1x9gknd 5267 37 was be VBD cord-010119-t1x9gknd 5267 38 regularly regularly RB cord-010119-t1x9gknd 5267 39 used use VBN cord-010119-t1x9gknd 5267 40 by by IN cord-010119-t1x9gknd 5267 41 all all DT cord-010119-t1x9gknd 5267 42 surgeons surgeon NNS cord-010119-t1x9gknd 5267 43 and and CC cord-010119-t1x9gknd 5267 44 anesthesiologists anesthesiologist NNS cord-010119-t1x9gknd 5267 45 ; ; : cord-010119-t1x9gknd 5267 46 10 10 CD cord-010119-t1x9gknd 5267 47 % % NN cord-010119-t1x9gknd 5267 48 felt feel VBD cord-010119-t1x9gknd 5267 49 that that IN cord-010119-t1x9gknd 5267 50 it -PRON- PRP cord-010119-t1x9gknd 5267 51 was be VBD cord-010119-t1x9gknd 5267 52 not not RB cord-010119-t1x9gknd 5267 53 used use VBN cord-010119-t1x9gknd 5267 54 at at RB cord-010119-t1x9gknd 5267 55 all all RB cord-010119-t1x9gknd 5267 56 at at IN cord-010119-t1x9gknd 5267 57 their -PRON- PRP$ cord-010119-t1x9gknd 5267 58 hospital hospital NN cord-010119-t1x9gknd 5267 59 , , , cord-010119-t1x9gknd 5267 60 36 36 CD cord-010119-t1x9gknd 5267 61 % % NN cord-010119-t1x9gknd 5267 62 did do VBD cord-010119-t1x9gknd 5267 63 not not RB cord-010119-t1x9gknd 5267 64 respond respond VB cord-010119-t1x9gknd 5267 65 . . . cord-010119-t1x9gknd 5268 1 Conclusion conclusion NN cord-010119-t1x9gknd 5268 2 : : : cord-010119-t1x9gknd 5269 1 An an DT cord-010119-t1x9gknd 5269 2 MSBOS msbo NNS cord-010119-t1x9gknd 5269 3 was be VBD cord-010119-t1x9gknd 5269 4 available available JJ cord-010119-t1x9gknd 5269 5 in in IN cord-010119-t1x9gknd 5269 6 only only RB cord-010119-t1x9gknd 5269 7 about about IN cord-010119-t1x9gknd 5269 8 half half NN cord-010119-t1x9gknd 5269 9 of of IN cord-010119-t1x9gknd 5269 10 the the DT cord-010119-t1x9gknd 5269 11 respondent respondent NN cord-010119-t1x9gknd 5269 12 's 's POS cord-010119-t1x9gknd 5269 13 hospitals hospital NNS cord-010119-t1x9gknd 5269 14 and and CC cord-010119-t1x9gknd 5269 15 in in IN cord-010119-t1x9gknd 5269 16 only only RB cord-010119-t1x9gknd 5269 17 the the DT cord-010119-t1x9gknd 5269 18 minority minority NN cord-010119-t1x9gknd 5269 19 of of IN cord-010119-t1x9gknd 5269 20 cases case NNS cord-010119-t1x9gknd 5269 21 was be VBD cord-010119-t1x9gknd 5269 22 it -PRON- PRP cord-010119-t1x9gknd 5269 23 felt feel VBD cord-010119-t1x9gknd 5269 24 to to TO cord-010119-t1x9gknd 5269 25 be be VB cord-010119-t1x9gknd 5269 26 regularly regularly RB cord-010119-t1x9gknd 5269 27 used use VBN cord-010119-t1x9gknd 5269 28 . . . cord-010119-t1x9gknd 5270 1 However however RB cord-010119-t1x9gknd 5270 2 , , , cord-010119-t1x9gknd 5270 3 18 18 CD cord-010119-t1x9gknd 5270 4 % % NN cord-010119-t1x9gknd 5270 5 of of IN cord-010119-t1x9gknd 5270 6 the the DT cord-010119-t1x9gknd 5270 7 hospitals hospital NNS cord-010119-t1x9gknd 5270 8 currently currently RB cord-010119-t1x9gknd 5270 9 without without IN cord-010119-t1x9gknd 5270 10 one one CD cord-010119-t1x9gknd 5270 11 indicated indicate VBD cord-010119-t1x9gknd 5270 12 that that IN cord-010119-t1x9gknd 5270 13 it -PRON- PRP cord-010119-t1x9gknd 5270 14 would would MD cord-010119-t1x9gknd 5270 15 be be VB cord-010119-t1x9gknd 5270 16 implemented implement VBN cord-010119-t1x9gknd 5270 17 in in IN cord-010119-t1x9gknd 5270 18 2017 2017 CD cord-010119-t1x9gknd 5270 19 suggesting suggest VBG cord-010119-t1x9gknd 5270 20 that that IN cord-010119-t1x9gknd 5270 21 these these DT cord-010119-t1x9gknd 5270 22 hospitals hospital NNS cord-010119-t1x9gknd 5270 23 perceive perceive VBP cord-010119-t1x9gknd 5270 24 the the DT cord-010119-t1x9gknd 5270 25 value value NN cord-010119-t1x9gknd 5270 26 of of IN cord-010119-t1x9gknd 5270 27 having have VBG cord-010119-t1x9gknd 5270 28 one one CD cord-010119-t1x9gknd 5270 29 in in IN cord-010119-t1x9gknd 5270 30 place place NN cord-010119-t1x9gknd 5270 31 . . . cord-010119-t1x9gknd 5271 1 Implementing implement VBG cord-010119-t1x9gknd 5271 2 and and CC cord-010119-t1x9gknd 5271 3 following follow VBG cord-010119-t1x9gknd 5271 4 an an DT cord-010119-t1x9gknd 5271 5 MSBOS MSBOS NNP cord-010119-t1x9gknd 5271 6 can can MD cord-010119-t1x9gknd 5271 7 be be VB cord-010119-t1x9gknd 5271 8 an an DT cord-010119-t1x9gknd 5271 9 important important JJ cord-010119-t1x9gknd 5271 10 step step NN cord-010119-t1x9gknd 5271 11 in in IN cord-010119-t1x9gknd 5271 12 peri peri JJ cord-010119-t1x9gknd 5271 13 - - HYPH cord-010119-t1x9gknd 5271 14 operative operative JJ cord-010119-t1x9gknd 5271 15 patient patient NN cord-010119-t1x9gknd 5271 16 blood blood NN cord-010119-t1x9gknd 5271 17 management management NN cord-010119-t1x9gknd 5271 18 and and CC cord-010119-t1x9gknd 5271 19 in in IN cord-010119-t1x9gknd 5271 20 streamlining streamline VBG cord-010119-t1x9gknd 5271 21 the the DT cord-010119-t1x9gknd 5271 22 operations operation NNS cord-010119-t1x9gknd 5271 23 of of IN cord-010119-t1x9gknd 5271 24 the the DT cord-010119-t1x9gknd 5271 25 blood blood NN cord-010119-t1x9gknd 5271 26 bank bank NN cord-010119-t1x9gknd 5271 27 vis vis FW cord-010119-t1x9gknd 5271 28 - - HYPH cord-010119-t1x9gknd 5271 29 a a FW cord-010119-t1x9gknd 5271 30 - - HYPH cord-010119-t1x9gknd 5271 31 vis vis FW cord-010119-t1x9gknd 5271 32 pre pre JJ cord-010119-t1x9gknd 5271 33 - - JJ cord-010119-t1x9gknd 5271 34 operative operative JJ cord-010119-t1x9gknd 5271 35 testing testing NN cord-010119-t1x9gknd 5271 36 . . . cord-010119-t1x9gknd 5272 1 Blood blood NN cord-010119-t1x9gknd 5272 2 Management Management NNP cord-010119-t1x9gknd 5272 3 -One -One NNP cord-010119-t1x9gknd 5272 4 Hospital Hospital NNP cord-010119-t1x9gknd 5272 5 System System NNP cord-010119-t1x9gknd 5272 6 Experience experience NN cord-010119-t1x9gknd 5273 1 Leana Leana NNP cord-010119-t1x9gknd 5273 2 Serrano Serrano NNP cord-010119-t1x9gknd 5273 3 Rahman Rahman NNP cord-010119-t1x9gknd 5274 1 * * NFP cord-010119-t1x9gknd 5274 2 , , , cord-010119-t1x9gknd 5274 3 Mallika Mallika NNP cord-010119-t1x9gknd 5274 4 Gupta Gupta NNP cord-010119-t1x9gknd 5274 5 , , , cord-010119-t1x9gknd 5274 6 Susan Susan NNP cord-010119-t1x9gknd 5274 7 Solometo Solometo NNP cord-010119-t1x9gknd 5274 8 , , , cord-010119-t1x9gknd 5274 9 Ronald Ronald NNP cord-010119-t1x9gknd 5274 10 Walsh Walsh NNP cord-010119-t1x9gknd 5274 11 and and CC cord-010119-t1x9gknd 5274 12 Joan Joan NNP cord-010119-t1x9gknd 5274 13 Uehlinger Uehlinger NNP cord-010119-t1x9gknd 5274 14 . . . cord-010119-t1x9gknd 5275 1 Montefiore Montefiore NNP cord-010119-t1x9gknd 5275 2 Medical Medical NNP cord-010119-t1x9gknd 5275 3 Center Center NNP cord-010119-t1x9gknd 5275 4 Background Background NNP cord-010119-t1x9gknd 5275 5 / / SYM cord-010119-t1x9gknd 5275 6 Case Case NNP cord-010119-t1x9gknd 5275 7 Studies Studies NNPS cord-010119-t1x9gknd 5275 8 : : : cord-010119-t1x9gknd 5276 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5276 2 system system NN cord-010119-t1x9gknd 5276 3 , , , cord-010119-t1x9gknd 5276 4 a a DT cord-010119-t1x9gknd 5276 5 Pioneer Pioneer NNP cord-010119-t1x9gknd 5276 6 ACO ACO NNP cord-010119-t1x9gknd 5276 7 , , , cord-010119-t1x9gknd 5276 8 is be VBZ cord-010119-t1x9gknd 5276 9 a a DT cord-010119-t1x9gknd 5276 10 1490-bed 1490-bed CD cord-010119-t1x9gknd 5276 11 tertiary tertiary JJ cord-010119-t1x9gknd 5276 12 - - HYPH cord-010119-t1x9gknd 5276 13 care care NN cord-010119-t1x9gknd 5276 14 referral referral NN cord-010119-t1x9gknd 5276 15 center center NN cord-010119-t1x9gknd 5276 16 dedicated dedicate VBN cord-010119-t1x9gknd 5276 17 to to IN cord-010119-t1x9gknd 5276 18 serving serve VBG cord-010119-t1x9gknd 5276 19 patients patient NNS cord-010119-t1x9gknd 5276 20 from from IN cord-010119-t1x9gknd 5276 21 across across IN cord-010119-t1x9gknd 5276 22 the the DT cord-010119-t1x9gknd 5276 23 New New NNP cord-010119-t1x9gknd 5276 24 York York NNP cord-010119-t1x9gknd 5276 25 City City NNP cord-010119-t1x9gknd 5276 26 area area NN cord-010119-t1x9gknd 5276 27 and and CC cord-010119-t1x9gknd 5276 28 beyond beyond IN cord-010119-t1x9gknd 5276 29 . . . cord-010119-t1x9gknd 5277 1 The the DT cord-010119-t1x9gknd 5277 2 comprising comprise VBG cord-010119-t1x9gknd 5277 3 four four CD cord-010119-t1x9gknd 5277 4 hospitals hospital NNS cord-010119-t1x9gknd 5277 5 see see VB cord-010119-t1x9gknd 5277 6 93,000 93,000 CD cord-010119-t1x9gknd 5277 7 hospital hospital NN cord-010119-t1x9gknd 5277 8 admissions admission NNS cord-010119-t1x9gknd 5277 9 and and CC cord-010119-t1x9gknd 5277 10 nearly nearly RB cord-010119-t1x9gknd 5277 11 300,000 300,000 CD cord-010119-t1x9gknd 5277 12 emergency emergency NN cord-010119-t1x9gknd 5277 13 department department NN cord-010119-t1x9gknd 5277 14 visits visit NNS cord-010119-t1x9gknd 5277 15 annually annually RB cord-010119-t1x9gknd 5277 16 . . . cord-010119-t1x9gknd 5278 1 We -PRON- PRP cord-010119-t1x9gknd 5278 2 have have VBP cord-010119-t1x9gknd 5278 3 active active JJ cord-010119-t1x9gknd 5278 4 programs program NNS cord-010119-t1x9gknd 5278 5 in in IN cord-010119-t1x9gknd 5278 6 high high JJ cord-010119-t1x9gknd 5278 7 risk risk NN cord-010119-t1x9gknd 5278 8 OB OB NNP cord-010119-t1x9gknd 5278 9 , , , cord-010119-t1x9gknd 5278 10 stem stem NN cord-010119-t1x9gknd 5278 11 cell cell NN cord-010119-t1x9gknd 5278 12 transplant transplant NN cord-010119-t1x9gknd 5278 13 , , , cord-010119-t1x9gknd 5278 14 solid solid JJ cord-010119-t1x9gknd 5278 15 organ organ NN cord-010119-t1x9gknd 5278 16 transplant transplant NN cord-010119-t1x9gknd 5278 17 ( ( -LRB- cord-010119-t1x9gknd 5278 18 heart heart NN cord-010119-t1x9gknd 5278 19 , , , cord-010119-t1x9gknd 5278 20 liver liver NN cord-010119-t1x9gknd 5278 21 , , , cord-010119-t1x9gknd 5278 22 and and CC cord-010119-t1x9gknd 5278 23 kidney kidney NN cord-010119-t1x9gknd 5278 24 ) ) -RRB- cord-010119-t1x9gknd 5278 25 , , , cord-010119-t1x9gknd 5278 26 CT CT NNP cord-010119-t1x9gknd 5278 27 surgery surgery NN cord-010119-t1x9gknd 5278 28 , , , cord-010119-t1x9gknd 5278 29 ECMO ECMO NNP cord-010119-t1x9gknd 5278 30 , , , cord-010119-t1x9gknd 5278 31 oncology oncology NN cord-010119-t1x9gknd 5278 32 and and CC cord-010119-t1x9gknd 5278 33 critical critical JJ cord-010119-t1x9gknd 5278 34 care care NN cord-010119-t1x9gknd 5278 35 . . . cord-010119-t1x9gknd 5279 1 Transfusion Transfusion NNP cord-010119-t1x9gknd 5279 2 Medicine Medicine NNP cord-010119-t1x9gknd 5279 3 plays play VBZ cord-010119-t1x9gknd 5279 4 a a DT cord-010119-t1x9gknd 5279 5 key key JJ cord-010119-t1x9gknd 5279 6 role role NN cord-010119-t1x9gknd 5279 7 in in IN cord-010119-t1x9gknd 5279 8 the the DT cord-010119-t1x9gknd 5279 9 support support NN cord-010119-t1x9gknd 5279 10 of of IN cord-010119-t1x9gknd 5279 11 these these DT cord-010119-t1x9gknd 5279 12 services service NNS cord-010119-t1x9gknd 5279 13 . . . cord-010119-t1x9gknd 5280 1 Blood blood NN cord-010119-t1x9gknd 5280 2 product product NN cord-010119-t1x9gknd 5280 3 spending spending NN cord-010119-t1x9gknd 5280 4 in in IN cord-010119-t1x9gknd 5280 5 2015 2015 CD cord-010119-t1x9gknd 5280 6 was be VBD cord-010119-t1x9gknd 5280 7 approximately approximately RB cord-010119-t1x9gknd 5280 8 $ $ $ cord-010119-t1x9gknd 5280 9 15.8M. 15.8m. CD cord-010119-t1x9gknd 5280 10 In in IN cord-010119-t1x9gknd 5280 11 Nov. November NNP cord-010119-t1x9gknd 5280 12 2015 2015 CD cord-010119-t1x9gknd 5280 13 , , , cord-010119-t1x9gknd 5280 14 an an DT cord-010119-t1x9gknd 5280 15 interdisciplinary interdisciplinary JJ cord-010119-t1x9gknd 5280 16 committee committee NN cord-010119-t1x9gknd 5280 17 was be VBD cord-010119-t1x9gknd 5280 18 created create VBN cord-010119-t1x9gknd 5280 19 in in IN cord-010119-t1x9gknd 5280 20 an an DT cord-010119-t1x9gknd 5280 21 effort effort NN cord-010119-t1x9gknd 5280 22 to to TO cord-010119-t1x9gknd 5280 23 improve improve VB cord-010119-t1x9gknd 5280 24 patient patient JJ cord-010119-t1x9gknd 5280 25 care care NN cord-010119-t1x9gknd 5280 26 ( ( -LRB- cord-010119-t1x9gknd 5280 27 by by IN cord-010119-t1x9gknd 5280 28 reducing reduce VBG cord-010119-t1x9gknd 5280 29 blood blood NN cord-010119-t1x9gknd 5280 30 product product NN cord-010119-t1x9gknd 5280 31 exposure exposure NN cord-010119-t1x9gknd 5280 32 ) ) -RRB- cord-010119-t1x9gknd 5280 33 and and CC cord-010119-t1x9gknd 5280 34 reduce reduce VB cord-010119-t1x9gknd 5280 35 blood blood NN cord-010119-t1x9gknd 5280 36 product product NN cord-010119-t1x9gknd 5280 37 expenditures expenditure NNS cord-010119-t1x9gknd 5280 38 . . . cord-010119-t1x9gknd 5281 1 The the DT cord-010119-t1x9gknd 5281 2 Vice Vice NNP cord-010119-t1x9gknd 5281 3 President President NNP cord-010119-t1x9gknd 5281 4 - - HYPH cord-010119-t1x9gknd 5281 5 sponsored sponsor VBN cord-010119-t1x9gknd 5281 6 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 5281 7 committee committee NN cord-010119-t1x9gknd 5281 8 was be VBD cord-010119-t1x9gknd 5281 9 composed compose VBN cord-010119-t1x9gknd 5281 10 of of IN cord-010119-t1x9gknd 5281 11 representatives representative NNS cord-010119-t1x9gknd 5281 12 of of IN cord-010119-t1x9gknd 5281 13 : : : cord-010119-t1x9gknd 5281 14 Surgery surgery NN cord-010119-t1x9gknd 5281 15 , , , cord-010119-t1x9gknd 5281 16 Anesthesia Anesthesia NNP cord-010119-t1x9gknd 5281 17 , , , cord-010119-t1x9gknd 5281 18 Blood Blood NNP cord-010119-t1x9gknd 5281 19 Bank Bank NNP cord-010119-t1x9gknd 5281 20 , , , cord-010119-t1x9gknd 5281 21 Pediatrics Pediatrics NNP cord-010119-t1x9gknd 5281 22 , , , cord-010119-t1x9gknd 5281 23 Perfusion perfusion NN cord-010119-t1x9gknd 5281 24 , , , cord-010119-t1x9gknd 5281 25 Cardiothoracic Cardiothoracic NNP cord-010119-t1x9gknd 5281 26 Surgery surgery NN cord-010119-t1x9gknd 5281 27 , , , cord-010119-t1x9gknd 5281 28 Critical Critical NNP cord-010119-t1x9gknd 5281 29 Care Care NNP cord-010119-t1x9gknd 5281 30 , , , cord-010119-t1x9gknd 5281 31 Medicine Medicine NNP cord-010119-t1x9gknd 5281 32 , , , cord-010119-t1x9gknd 5281 33 and and CC cord-010119-t1x9gknd 5281 34 Emergency Emergency NNP cord-010119-t1x9gknd 5281 35 Department Department NNP cord-010119-t1x9gknd 5281 36 . . . cord-010119-t1x9gknd 5282 1 Study Study NNP cord-010119-t1x9gknd 5282 2 Design Design NNP cord-010119-t1x9gknd 5282 3 / / SYM cord-010119-t1x9gknd 5282 4 Method method NN cord-010119-t1x9gknd 5282 5 : : : cord-010119-t1x9gknd 5283 1 First first JJ cord-010119-t1x9gknd 5283 2 Important important JJ cord-010119-t1x9gknd 5283 3 Step step NN cord-010119-t1x9gknd 5283 4 : : : cord-010119-t1x9gknd 5283 5 " " `` cord-010119-t1x9gknd 5283 6 Know know VB cord-010119-t1x9gknd 5283 7 your -PRON- PRP$ cord-010119-t1x9gknd 5283 8 numbers"-Although numbers"-Although NNP cord-010119-t1x9gknd 5284 1 the the DT cord-010119-t1x9gknd 5284 2 committee committee NN cord-010119-t1x9gknd 5284 3 had have VBD cord-010119-t1x9gknd 5284 4 multiple multiple JJ cord-010119-t1x9gknd 5284 5 sources source NNS cord-010119-t1x9gknd 5284 6 of of IN cord-010119-t1x9gknd 5284 7 data datum NNS cord-010119-t1x9gknd 5284 8 , , , cord-010119-t1x9gknd 5284 9 there there EX cord-010119-t1x9gknd 5284 10 was be VBD cord-010119-t1x9gknd 5284 11 no no DT cord-010119-t1x9gknd 5284 12 " " `` cord-010119-t1x9gknd 5284 13 one one CD cord-010119-t1x9gknd 5284 14 report report NN cord-010119-t1x9gknd 5284 15 " " '' cord-010119-t1x9gknd 5284 16 that that WDT cord-010119-t1x9gknd 5284 17 could could MD cord-010119-t1x9gknd 5284 18 display display VB cord-010119-t1x9gknd 5284 19 all all DT cord-010119-t1x9gknd 5284 20 of of IN cord-010119-t1x9gknd 5284 21 the the DT cord-010119-t1x9gknd 5284 22 pertinent pertinent JJ cord-010119-t1x9gknd 5284 23 information information NN cord-010119-t1x9gknd 5284 24 . . . cord-010119-t1x9gknd 5285 1 Baseline baseline JJ cord-010119-t1x9gknd 5285 2 numbers number NNS cord-010119-t1x9gknd 5285 3 were be VBD cord-010119-t1x9gknd 5285 4 imperative imperative JJ cord-010119-t1x9gknd 5285 5 to to IN cord-010119-t1x9gknd 5285 6 the the DT cord-010119-t1x9gknd 5285 7 committee committee NN cord-010119-t1x9gknd 5285 8 's 's POS cord-010119-t1x9gknd 5285 9 ability ability NN cord-010119-t1x9gknd 5285 10 to to TO cord-010119-t1x9gknd 5285 11 effect effect VB cord-010119-t1x9gknd 5285 12 change change NN cord-010119-t1x9gknd 5285 13 . . . cord-010119-t1x9gknd 5286 1 A a DT cord-010119-t1x9gknd 5286 2 home home NN cord-010119-t1x9gknd 5286 3 grown grow VBN cord-010119-t1x9gknd 5287 1 one one CD cord-010119-t1x9gknd 5287 2 time time NN cord-010119-t1x9gknd 5287 3 only only RB cord-010119-t1x9gknd 5287 4 report report NN cord-010119-t1x9gknd 5287 5 revealed reveal VBD cord-010119-t1x9gknd 5287 6 which which WDT cord-010119-t1x9gknd 5287 7 services service NNS cord-010119-t1x9gknd 5287 8 and and CC cord-010119-t1x9gknd 5287 9 clinicians clinician NNS cord-010119-t1x9gknd 5287 10 were be VBD cord-010119-t1x9gknd 5287 11 the the DT cord-010119-t1x9gknd 5287 12 highest high JJS cord-010119-t1x9gknd 5287 13 volume volume NN cord-010119-t1x9gknd 5287 14 users user NNS cord-010119-t1x9gknd 5287 15 . . . cord-010119-t1x9gknd 5288 1 The the DT cord-010119-t1x9gknd 5288 2 initial initial JJ cord-010119-t1x9gknd 5288 3 plan plan NN cord-010119-t1x9gknd 5288 4 was be VBD cord-010119-t1x9gknd 5288 5 to to TO cord-010119-t1x9gknd 5288 6 target target VB cord-010119-t1x9gknd 5288 7 their -PRON- PRP$ cord-010119-t1x9gknd 5288 8 use use NN cord-010119-t1x9gknd 5288 9 with with IN cord-010119-t1x9gknd 5288 10 education education NN cord-010119-t1x9gknd 5288 11 . . . cord-010119-t1x9gknd 5289 1 An an DT cord-010119-t1x9gknd 5289 2 initial initial JJ cord-010119-t1x9gknd 5289 3 goal goal NN cord-010119-t1x9gknd 5289 4 was be VBD cord-010119-t1x9gknd 5289 5 set set VBN cord-010119-t1x9gknd 5289 6 to to TO cord-010119-t1x9gknd 5289 7 reduce reduce VB cord-010119-t1x9gknd 5289 8 expenditure expenditure NN cord-010119-t1x9gknd 5289 9 by by IN cord-010119-t1x9gknd 5289 10 $ $ $ cord-010119-t1x9gknd 5289 11 1.2M. 1.2m. CD cord-010119-t1x9gknd 5290 1 The the DT cord-010119-t1x9gknd 5290 2 journey journey NN cord-010119-t1x9gknd 5290 3 continued continue VBD cord-010119-t1x9gknd 5290 4 with with IN cord-010119-t1x9gknd 5290 5 regular regular JJ cord-010119-t1x9gknd 5290 6 bimonthly bimonthly JJ cord-010119-t1x9gknd 5290 7 meetingsto meetingsto FW cord-010119-t1x9gknd 5290 8 brainstorm brainstorm NN cord-010119-t1x9gknd 5290 9 strategies strategy NNS cord-010119-t1x9gknd 5290 10 and and CC cord-010119-t1x9gknd 5290 11 monitor monitor VB cord-010119-t1x9gknd 5290 12 utilization utilization NN cord-010119-t1x9gknd 5290 13 . . . cord-010119-t1x9gknd 5291 1 Utilization utilization NN cord-010119-t1x9gknd 5291 2 was be VBD cord-010119-t1x9gknd 5291 3 analyzed analyze VBN cord-010119-t1x9gknd 5291 4 using use VBG cord-010119-t1x9gknd 5291 5 a a DT cord-010119-t1x9gknd 5291 6 home home NN cord-010119-t1x9gknd 5291 7 grown grow VBN cord-010119-t1x9gknd 5291 8 crystal crystal NN cord-010119-t1x9gknd 5291 9 report report NN cord-010119-t1x9gknd 5291 10 " " `` cord-010119-t1x9gknd 5291 11 Transfused Transfused NNP cord-010119-t1x9gknd 5291 12 Patients patient NNS cord-010119-t1x9gknd 5291 13 by by IN cord-010119-t1x9gknd 5291 14 Location Location NNP cord-010119-t1x9gknd 5291 15 " " '' cord-010119-t1x9gknd 5291 16 . . . cord-010119-t1x9gknd 5292 1 This this DT cord-010119-t1x9gknd 5292 2 report report NN cord-010119-t1x9gknd 5292 3 was be VBD cord-010119-t1x9gknd 5292 4 further further RB cord-010119-t1x9gknd 5292 5 compared compare VBN cord-010119-t1x9gknd 5292 6 to to IN cord-010119-t1x9gknd 5292 7 utilization utilization NN cord-010119-t1x9gknd 5292 8 patterns pattern NNS cord-010119-t1x9gknd 5292 9 ( ( -LRB- cord-010119-t1x9gknd 5292 10 2014 2014 CD cord-010119-t1x9gknd 5292 11 and and CC cord-010119-t1x9gknd 5292 12 2015 2015 CD cord-010119-t1x9gknd 5292 13 ) ) -RRB- cord-010119-t1x9gknd 5292 14 , , , cord-010119-t1x9gknd 5292 15 by by IN cord-010119-t1x9gknd 5292 16 " " `` cord-010119-t1x9gknd 5292 17 dollars dollar NNS cord-010119-t1x9gknd 5292 18 spent spend VBN cord-010119-t1x9gknd 5292 19 " " '' cord-010119-t1x9gknd 5292 20 and and CC cord-010119-t1x9gknd 5292 21 " " `` cord-010119-t1x9gknd 5292 22 total total JJ cord-010119-t1x9gknd 5292 23 units unit NNS cord-010119-t1x9gknd 5292 24 per per IN cord-010119-t1x9gknd 5292 25 patient patient NN cord-010119-t1x9gknd 5292 26 " " '' cord-010119-t1x9gknd 5292 27 by by IN cord-010119-t1x9gknd 5292 28 the the DT cord-010119-t1x9gknd 5292 29 project project NN cord-010119-t1x9gknd 5292 30 manager manager NN cord-010119-t1x9gknd 5292 31 using use VBG cord-010119-t1x9gknd 5292 32 excel excel NNP cord-010119-t1x9gknd 5292 33 . . . cord-010119-t1x9gknd 5293 1 Key Key NNP cord-010119-t1x9gknd 5293 2 Initiatives Initiatives NNPS cord-010119-t1x9gknd 5293 3 developed develop VBN cord-010119-t1x9gknd 5293 4 by by IN cord-010119-t1x9gknd 5293 5 the the DT cord-010119-t1x9gknd 5293 6 committee committee NN cord-010119-t1x9gknd 5293 7 1 1 CD cord-010119-t1x9gknd 5293 8 . . . cord-010119-t1x9gknd 5294 1 Development development NN cord-010119-t1x9gknd 5294 2 of of IN cord-010119-t1x9gknd 5294 3 evidence evidence NN cord-010119-t1x9gknd 5294 4 based base VBN cord-010119-t1x9gknd 5294 5 transfusion transfusion NN cord-010119-t1x9gknd 5294 6 triggers trigger NNS cord-010119-t1x9gknd 5294 7 . . . cord-010119-t1x9gknd 5295 1 2 2 LS cord-010119-t1x9gknd 5295 2 . . . cord-010119-t1x9gknd 5296 1 Education education NN cord-010119-t1x9gknd 5296 2 on on IN cord-010119-t1x9gknd 5296 3 evidence evidence NN cord-010119-t1x9gknd 5296 4 based base VBN cord-010119-t1x9gknd 5296 5 transfusion transfusion NN cord-010119-t1x9gknd 5296 6 triggers trigger VBZ cord-010119-t1x9gknd 5296 7 across across IN cord-010119-t1x9gknd 5296 8 multiple multiple JJ cord-010119-t1x9gknd 5296 9 campuses campus NNS cord-010119-t1x9gknd 5296 10 , , , cord-010119-t1x9gknd 5296 11 specialties specialty NNS cord-010119-t1x9gknd 5296 12 and and CC cord-010119-t1x9gknd 5296 13 resident resident NN cord-010119-t1x9gknd 5296 14 programs program NNS cord-010119-t1x9gknd 5296 15 3 3 CD cord-010119-t1x9gknd 5296 16 . . . cord-010119-t1x9gknd 5297 1 Clinical clinical JJ cord-010119-t1x9gknd 5297 2 Information information NN cord-010119-t1x9gknd 5297 3 System System NNP cord-010119-t1x9gknd 5297 4 ( ( -LRB- cord-010119-t1x9gknd 5297 5 CIS CIS NNP cord-010119-t1x9gknd 5297 6 ) ) -RRB- cord-010119-t1x9gknd 5297 7 " " `` cord-010119-t1x9gknd 5297 8 soft soft JJ cord-010119-t1x9gknd 5297 9 stops stop NNS cord-010119-t1x9gknd 5297 10 " " '' cord-010119-t1x9gknd 5297 11 when when WRB cord-010119-t1x9gknd 5297 12 ordering order VBG cord-010119-t1x9gknd 5297 13 blood blood NN cord-010119-t1x9gknd 5297 14 products product NNS cord-010119-t1x9gknd 5297 15 outside outside IN cord-010119-t1x9gknd 5297 16 guidelines guideline NNS cord-010119-t1x9gknd 5297 17 . . . cord-010119-t1x9gknd 5298 1 RBC RBC NNP cord-010119-t1x9gknd 5298 2 order order NN cord-010119-t1x9gknd 5298 3 set set VBD cord-010119-t1x9gknd 5298 4 defaulting default VBG cord-010119-t1x9gknd 5298 5 to to IN cord-010119-t1x9gknd 5298 6 " " `` cord-010119-t1x9gknd 5298 7 1 1 CD cord-010119-t1x9gknd 5298 8 " " '' cord-010119-t1x9gknd 5298 9 unit unit NN cord-010119-t1x9gknd 5298 10 instead instead RB cord-010119-t1x9gknd 5298 11 of of IN cord-010119-t1x9gknd 5298 12 " " `` cord-010119-t1x9gknd 5298 13 2 2 CD cord-010119-t1x9gknd 5298 14 " " '' cord-010119-t1x9gknd 5298 15 units unit NNS cord-010119-t1x9gknd 5298 16 . . . cord-010119-t1x9gknd 5299 1 4 4 LS cord-010119-t1x9gknd 5299 2 . . . cord-010119-t1x9gknd 5300 1 Updated update VBN cord-010119-t1x9gknd 5300 2 guidelines guideline NNS cord-010119-t1x9gknd 5300 3 posted post VBN cord-010119-t1x9gknd 5300 4 to to TO cord-010119-t1x9gknd 5300 5 easy easy VB cord-010119-t1x9gknd 5300 6 to to TO cord-010119-t1x9gknd 5300 7 find find VB cord-010119-t1x9gknd 5300 8 internal internal JJ cord-010119-t1x9gknd 5300 9 intranet intranet NN cord-010119-t1x9gknd 5300 10 spots spot NNS cord-010119-t1x9gknd 5301 1 Results result NNS cord-010119-t1x9gknd 5302 1 /Finding /finde VBG cord-010119-t1x9gknd 5302 2 : : : cord-010119-t1x9gknd 5303 1 Despite despite IN cord-010119-t1x9gknd 5303 2 higher high JJR cord-010119-t1x9gknd 5303 3 patient patient NN cord-010119-t1x9gknd 5303 4 volumes volume NNS cord-010119-t1x9gknd 5303 5 and and CC cord-010119-t1x9gknd 5303 6 a a DT cord-010119-t1x9gknd 5303 7 more more RBR cord-010119-t1x9gknd 5303 8 complicated complicated JJ cord-010119-t1x9gknd 5303 9 patient patient NN cord-010119-t1x9gknd 5303 10 mix mix NN cord-010119-t1x9gknd 5303 11 in in IN cord-010119-t1x9gknd 5303 12 2016 2016 CD cord-010119-t1x9gknd 5303 13 , , , cord-010119-t1x9gknd 5303 14 we -PRON- PRP cord-010119-t1x9gknd 5303 15 were be VBD cord-010119-t1x9gknd 5303 16 still still RB cord-010119-t1x9gknd 5303 17 able able JJ cord-010119-t1x9gknd 5303 18 to to TO cord-010119-t1x9gknd 5303 19 reduced reduce VBN cord-010119-t1x9gknd 5303 20 blood blood NN cord-010119-t1x9gknd 5303 21 product product NN cord-010119-t1x9gknd 5303 22 expenditures expenditure NNS cord-010119-t1x9gknd 5303 23 by by IN cord-010119-t1x9gknd 5303 24 $ $ $ cord-010119-t1x9gknd 5303 25 933,874 933,874 CD cord-010119-t1x9gknd 5303 26 when when WRB cord-010119-t1x9gknd 5303 27 compared compare VBN cord-010119-t1x9gknd 5303 28 to to IN cord-010119-t1x9gknd 5303 29 2015 2015 CD cord-010119-t1x9gknd 5303 30 . . . cord-010119-t1x9gknd 5304 1 Conclusion conclusion NN cord-010119-t1x9gknd 5304 2 : : : cord-010119-t1x9gknd 5305 1 In in IN cord-010119-t1x9gknd 5305 2 spite spite NN cord-010119-t1x9gknd 5305 3 of of IN cord-010119-t1x9gknd 5305 4 limited limited JJ cord-010119-t1x9gknd 5305 5 resources resource NNS cord-010119-t1x9gknd 5305 6 , , , cord-010119-t1x9gknd 5305 7 the the DT cord-010119-t1x9gknd 5305 8 committee committee NN cord-010119-t1x9gknd 5305 9 was be VBD cord-010119-t1x9gknd 5305 10 able able JJ cord-010119-t1x9gknd 5305 11 to to TO cord-010119-t1x9gknd 5305 12 effect effect VB cord-010119-t1x9gknd 5305 13 change change NN cord-010119-t1x9gknd 5305 14 by by IN cord-010119-t1x9gknd 5305 15 capitalizing capitalize VBG cord-010119-t1x9gknd 5305 16 on on IN cord-010119-t1x9gknd 5305 17 current current JJ cord-010119-t1x9gknd 5305 18 stakeholders stakeholder NNS cord-010119-t1x9gknd 5305 19 fully fully RB cord-010119-t1x9gknd 5305 20 supported support VBN cord-010119-t1x9gknd 5305 21 by by IN cord-010119-t1x9gknd 5305 22 leadership leadership NN cord-010119-t1x9gknd 5305 23 and and CC cord-010119-t1x9gknd 5305 24 project project NN cord-010119-t1x9gknd 5305 25 management management NN cord-010119-t1x9gknd 5305 26 . . . cord-010119-t1x9gknd 5306 1 Cord Cord NNP cord-010119-t1x9gknd 5306 2 Blood Blood NNP cord-010119-t1x9gknd 5306 3 Pathway Pathway NNP cord-010119-t1x9gknd 5306 4 to to TO cord-010119-t1x9gknd 5306 5 Reduce reduce VB cord-010119-t1x9gknd 5306 6 Iatrogenic iatrogenic JJ cord-010119-t1x9gknd 5306 7 Blood blood NN cord-010119-t1x9gknd 5306 8 Loss loss NN cord-010119-t1x9gknd 5306 9 in in IN cord-010119-t1x9gknd 5306 10 Neonatal Neonatal NNP cord-010119-t1x9gknd 5306 11 Intensive Intensive NNP cord-010119-t1x9gknd 5306 12 Care Care NNP cord-010119-t1x9gknd 5306 13 Patients patient VBZ cord-010119-t1x9gknd 5306 14 Tracy Tracy NNP cord-010119-t1x9gknd 5306 15 Shachner Shachner NNP cord-010119-t1x9gknd 5306 16 * * NFP cord-010119-t1x9gknd 5306 17 1 1 CD cord-010119-t1x9gknd 5306 18 , , , cord-010119-t1x9gknd 5306 19 Anna Anna NNP cord-010119-t1x9gknd 5306 20 W W NNP cord-010119-t1x9gknd 5306 21 Rains Rains NNP cord-010119-t1x9gknd 5306 22 2 2 CD cord-010119-t1x9gknd 5306 23 and and CC cord-010119-t1x9gknd 5306 24 Christopher Christopher NNP cord-010119-t1x9gknd 5306 25 T T NNP cord-010119-t1x9gknd 5306 26 Clark Clark NNP cord-010119-t1x9gknd 5306 27 3 3 CD cord-010119-t1x9gknd 5306 28 . . . cord-010119-t1x9gknd 5307 1 1 1 CD cord-010119-t1x9gknd 5307 2 University University NNP cord-010119-t1x9gknd 5307 3 of of IN cord-010119-t1x9gknd 5307 4 Tennessee Tennessee NNP cord-010119-t1x9gknd 5307 5 Graduate Graduate NNP cord-010119-t1x9gknd 5307 6 School School NNP cord-010119-t1x9gknd 5307 7 of of IN cord-010119-t1x9gknd 5307 8 Medicine Medicine NNP cord-010119-t1x9gknd 5307 9 , , , cord-010119-t1x9gknd 5307 10 2 2 CD cord-010119-t1x9gknd 5307 11 Univeristy Univeristy NNP cord-010119-t1x9gknd 5307 12 of of IN cord-010119-t1x9gknd 5307 13 Tennessee Tennessee NNP cord-010119-t1x9gknd 5307 14 Medical Medical NNP cord-010119-t1x9gknd 5307 15 Center Center NNP cord-010119-t1x9gknd 5307 16 , , , cord-010119-t1x9gknd 5307 17 3 3 CD cord-010119-t1x9gknd 5307 18 Univeristy Univeristy NNP cord-010119-t1x9gknd 5307 19 of of IN cord-010119-t1x9gknd 5307 20 Tennessee Tennessee NNP cord-010119-t1x9gknd 5307 21 Graduate Graduate NNP cord-010119-t1x9gknd 5307 22 School School NNP cord-010119-t1x9gknd 5307 23 of of IN cord-010119-t1x9gknd 5307 24 Medicine Medicine NNP cord-010119-t1x9gknd 5307 25 Background Background NNP cord-010119-t1x9gknd 5307 26 / / SYM cord-010119-t1x9gknd 5307 27 Case Case NNP cord-010119-t1x9gknd 5307 28 Studies Studies NNPS cord-010119-t1x9gknd 5307 29 : : : cord-010119-t1x9gknd 5308 1 Anemia anemia NN cord-010119-t1x9gknd 5308 2 due due JJ cord-010119-t1x9gknd 5308 3 to to IN cord-010119-t1x9gknd 5308 4 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 5308 5 blood blood NN cord-010119-t1x9gknd 5308 6 loss loss NN cord-010119-t1x9gknd 5308 7 in in IN cord-010119-t1x9gknd 5308 8 preterm preterm NNS cord-010119-t1x9gknd 5308 9 and and CC cord-010119-t1x9gknd 5308 10 low low JJ cord-010119-t1x9gknd 5308 11 birth birth NN cord-010119-t1x9gknd 5308 12 weight weight NN cord-010119-t1x9gknd 5308 13 infants infant NNS cord-010119-t1x9gknd 5308 14 is be VBZ cord-010119-t1x9gknd 5308 15 a a DT cord-010119-t1x9gknd 5308 16 major major JJ cord-010119-t1x9gknd 5308 17 contributory contributory JJ cord-010119-t1x9gknd 5308 18 factor factor NN cord-010119-t1x9gknd 5308 19 leading lead VBG cord-010119-t1x9gknd 5308 20 to to IN cord-010119-t1x9gknd 5308 21 red red JJ cord-010119-t1x9gknd 5308 22 blood blood NN cord-010119-t1x9gknd 5308 23 cell cell NN cord-010119-t1x9gknd 5308 24 transfusion transfusion NN cord-010119-t1x9gknd 5308 25 in in IN cord-010119-t1x9gknd 5308 26 this this DT cord-010119-t1x9gknd 5308 27 patient patient JJ cord-010119-t1x9gknd 5308 28 population population NN cord-010119-t1x9gknd 5308 29 . . . cord-010119-t1x9gknd 5309 1 Methods method NNS cord-010119-t1x9gknd 5309 2 to to TO cord-010119-t1x9gknd 5309 3 reduce reduce VB cord-010119-t1x9gknd 5309 4 phlebotomy phlebotomy NN cord-010119-t1x9gknd 5309 5 for for IN cord-010119-t1x9gknd 5309 6 laboratory laboratory NN cord-010119-t1x9gknd 5309 7 testing testing NN cord-010119-t1x9gknd 5309 8 can can MD cord-010119-t1x9gknd 5309 9 reduce reduce VB cord-010119-t1x9gknd 5309 10 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 5309 11 anemia anemia NN cord-010119-t1x9gknd 5309 12 . . . cord-010119-t1x9gknd 5310 1 At at IN cord-010119-t1x9gknd 5310 2 a a DT cord-010119-t1x9gknd 5310 3 universitybased universitybased JJ cord-010119-t1x9gknd 5310 4 teaching teaching NN cord-010119-t1x9gknd 5310 5 hospital hospital NN cord-010119-t1x9gknd 5310 6 , , , cord-010119-t1x9gknd 5310 7 a a DT cord-010119-t1x9gknd 5310 8 pathway pathway NN cord-010119-t1x9gknd 5310 9 to to TO cord-010119-t1x9gknd 5310 10 collect collect VB cord-010119-t1x9gknd 5310 11 cord cord NN cord-010119-t1x9gknd 5310 12 blood blood NN cord-010119-t1x9gknd 5310 13 samples sample NNS cord-010119-t1x9gknd 5310 14 on on IN cord-010119-t1x9gknd 5310 15 all all DT cord-010119-t1x9gknd 5310 16 newborn newborn JJ cord-010119-t1x9gknd 5310 17 deliveries delivery NNS cord-010119-t1x9gknd 5310 18 was be VBD cord-010119-t1x9gknd 5310 19 established establish VBN cord-010119-t1x9gknd 5310 20 . . . cord-010119-t1x9gknd 5311 1 The the DT cord-010119-t1x9gknd 5311 2 cord cord NN cord-010119-t1x9gknd 5311 3 blood blood NN cord-010119-t1x9gknd 5311 4 sample sample NN cord-010119-t1x9gknd 5311 5 is be VBZ cord-010119-t1x9gknd 5311 6 used use VBN cord-010119-t1x9gknd 5311 7 for for IN cord-010119-t1x9gknd 5311 8 initial initial JJ cord-010119-t1x9gknd 5311 9 blood blood NN cord-010119-t1x9gknd 5311 10 bank bank NN cord-010119-t1x9gknd 5311 11 laboratory laboratory NN cord-010119-t1x9gknd 5311 12 testing testing NN cord-010119-t1x9gknd 5311 13 on on IN cord-010119-t1x9gknd 5311 14 newborn newborn JJ cord-010119-t1x9gknd 5311 15 patients patient NNS cord-010119-t1x9gknd 5311 16 transferred transfer VBN cord-010119-t1x9gknd 5311 17 to to IN cord-010119-t1x9gknd 5311 18 the the DT cord-010119-t1x9gknd 5311 19 neonatal neonatal JJ cord-010119-t1x9gknd 5311 20 intensive intensive JJ cord-010119-t1x9gknd 5311 21 care care NN cord-010119-t1x9gknd 5311 22 unit unit NN cord-010119-t1x9gknd 5311 23 ( ( -LRB- cord-010119-t1x9gknd 5311 24 NICU NICU NNP cord-010119-t1x9gknd 5311 25 ) ) -RRB- cord-010119-t1x9gknd 5311 26 , , , cord-010119-t1x9gknd 5311 27 preventing prevent VBG cord-010119-t1x9gknd 5311 28 need need NN cord-010119-t1x9gknd 5311 29 for for IN cord-010119-t1x9gknd 5311 30 additional additional JJ cord-010119-t1x9gknd 5311 31 blood blood NN cord-010119-t1x9gknd 5311 32 draw draw NN cord-010119-t1x9gknd 5311 33 . . . cord-010119-t1x9gknd 5312 1 The the DT cord-010119-t1x9gknd 5312 2 blood blood NN cord-010119-t1x9gknd 5312 3 tubes tube NNS cord-010119-t1x9gknd 5312 4 are be VBP cord-010119-t1x9gknd 5312 5 saved save VBN cord-010119-t1x9gknd 5312 6 for for IN cord-010119-t1x9gknd 5312 7 1 1 CD cord-010119-t1x9gknd 5312 8 week week NN cord-010119-t1x9gknd 5312 9 post post NN cord-010119-t1x9gknd 5312 10 - - NN cord-010119-t1x9gknd 5312 11 delivery delivery NN cord-010119-t1x9gknd 5312 12 , , , cord-010119-t1x9gknd 5312 13 with with IN cord-010119-t1x9gknd 5312 14 cost cost NN cord-010119-t1x9gknd 5312 15 of of IN cord-010119-t1x9gknd 5312 16 $ $ $ cord-010119-t1x9gknd 5312 17 1.10 1.10 CD cord-010119-t1x9gknd 5312 18 per per IN cord-010119-t1x9gknd 5312 19 delivery delivery NN cord-010119-t1x9gknd 5312 20 tray tray NN cord-010119-t1x9gknd 5312 21 for for IN cord-010119-t1x9gknd 5312 22 sterile sterile JJ cord-010119-t1x9gknd 5312 23 tubes tube NNS cord-010119-t1x9gknd 5312 24 . . . cord-010119-t1x9gknd 5313 1 With with IN cord-010119-t1x9gknd 5313 2 an an DT cord-010119-t1x9gknd 5313 3 initial initial JJ cord-010119-t1x9gknd 5313 4 negative negative JJ cord-010119-t1x9gknd 5313 5 antibody antibody NN cord-010119-t1x9gknd 5313 6 screen screen NN cord-010119-t1x9gknd 5313 7 on on IN cord-010119-t1x9gknd 5313 8 cord cord NN cord-010119-t1x9gknd 5313 9 blood blood NN cord-010119-t1x9gknd 5313 10 sample sample NN cord-010119-t1x9gknd 5313 11 , , , cord-010119-t1x9gknd 5313 12 no no DT cord-010119-t1x9gknd 5313 13 additional additional JJ cord-010119-t1x9gknd 5313 14 phlebotomy phlebotomy NN cord-010119-t1x9gknd 5313 15 is be VBZ cord-010119-t1x9gknd 5313 16 required require VBN cord-010119-t1x9gknd 5313 17 for for IN cord-010119-t1x9gknd 5313 18 blood blood NN cord-010119-t1x9gknd 5313 19 product product NN cord-010119-t1x9gknd 5313 20 selection selection NN cord-010119-t1x9gknd 5313 21 or or CC cord-010119-t1x9gknd 5313 22 compatibility compatibility NN cord-010119-t1x9gknd 5313 23 testing testing NN cord-010119-t1x9gknd 5313 24 in in IN cord-010119-t1x9gknd 5313 25 this this DT cord-010119-t1x9gknd 5313 26 population population NN cord-010119-t1x9gknd 5313 27 until until IN cord-010119-t1x9gknd 5313 28 four four CD cord-010119-t1x9gknd 5313 29 months month NNS cord-010119-t1x9gknd 5313 30 of of IN cord-010119-t1x9gknd 5313 31 age age NN cord-010119-t1x9gknd 5313 32 . . . cord-010119-t1x9gknd 5314 1 Study Study NNP cord-010119-t1x9gknd 5314 2 Design Design NNP cord-010119-t1x9gknd 5314 3 / / SYM cord-010119-t1x9gknd 5314 4 Method method NN cord-010119-t1x9gknd 5314 5 : : : cord-010119-t1x9gknd 5315 1 Labor labor NN cord-010119-t1x9gknd 5315 2 and and CC cord-010119-t1x9gknd 5315 3 delivery delivery NN cord-010119-t1x9gknd 5315 4 data datum NNS cord-010119-t1x9gknd 5315 5 from from IN cord-010119-t1x9gknd 5315 6 our -PRON- PRP$ cord-010119-t1x9gknd 5315 7 facility facility NN cord-010119-t1x9gknd 5315 8 in in IN cord-010119-t1x9gknd 5315 9 2016 2016 CD cord-010119-t1x9gknd 5315 10 was be VBD cord-010119-t1x9gknd 5315 11 analyzed analyze VBN cord-010119-t1x9gknd 5315 12 , , , cord-010119-t1x9gknd 5315 13 and and CC cord-010119-t1x9gknd 5315 14 the the DT cord-010119-t1x9gknd 5315 15 gestational gestational JJ cord-010119-t1x9gknd 5315 16 age age NN cord-010119-t1x9gknd 5315 17 and and CC cord-010119-t1x9gknd 5315 18 birth birth NN cord-010119-t1x9gknd 5315 19 weight weight NN cord-010119-t1x9gknd 5315 20 of of IN cord-010119-t1x9gknd 5315 21 all all DT cord-010119-t1x9gknd 5315 22 infants infant NNS cord-010119-t1x9gknd 5315 23 transferred transfer VBN cord-010119-t1x9gknd 5315 24 to to IN cord-010119-t1x9gknd 5315 25 the the DT cord-010119-t1x9gknd 5315 26 NICU NICU NNP cord-010119-t1x9gknd 5315 27 was be VBD cord-010119-t1x9gknd 5315 28 collected collect VBN cord-010119-t1x9gknd 5315 29 . . . cord-010119-t1x9gknd 5316 1 From from IN cord-010119-t1x9gknd 5316 2 this this DT cord-010119-t1x9gknd 5316 3 data data NN cord-010119-t1x9gknd 5316 4 , , , cord-010119-t1x9gknd 5316 5 we -PRON- PRP cord-010119-t1x9gknd 5316 6 were be VBD cord-010119-t1x9gknd 5316 7 able able JJ cord-010119-t1x9gknd 5316 8 to to TO cord-010119-t1x9gknd 5316 9 calculate calculate VB cord-010119-t1x9gknd 5316 10 the the DT cord-010119-t1x9gknd 5316 11 total total JJ cord-010119-t1x9gknd 5316 12 blood blood NN cord-010119-t1x9gknd 5316 13 volume volume NN cord-010119-t1x9gknd 5316 14 of of IN cord-010119-t1x9gknd 5316 15 these these DT cord-010119-t1x9gknd 5316 16 infants infant NNS cord-010119-t1x9gknd 5316 17 using use VBG cord-010119-t1x9gknd 5316 18 MedCalc MedCalc NNP cord-010119-t1x9gknd 5316 19 3000 3000 CD cord-010119-t1x9gknd 5316 20 system system NN cord-010119-t1x9gknd 5316 21 . . . cord-010119-t1x9gknd 5317 1 By by IN cord-010119-t1x9gknd 5317 2 using use VBG cord-010119-t1x9gknd 5317 3 the the DT cord-010119-t1x9gknd 5317 4 blood blood NN cord-010119-t1x9gknd 5317 5 volume volume NN cord-010119-t1x9gknd 5317 6 values value NNS cord-010119-t1x9gknd 5317 7 , , , cord-010119-t1x9gknd 5317 8 and and CC cord-010119-t1x9gknd 5317 9 assigning assign VBG cord-010119-t1x9gknd 5317 10 a a DT cord-010119-t1x9gknd 5317 11 value value NN cord-010119-t1x9gknd 5317 12 of of IN cord-010119-t1x9gknd 5317 13 1.5 1.5 CD cord-010119-t1x9gknd 5317 14 mL mL NNS cord-010119-t1x9gknd 5317 15 as as IN cord-010119-t1x9gknd 5317 16 the the DT cord-010119-t1x9gknd 5317 17 minimum minimum NN cord-010119-t1x9gknd 5317 18 amount amount NN cord-010119-t1x9gknd 5317 19 of of IN cord-010119-t1x9gknd 5317 20 blood blood NN cord-010119-t1x9gknd 5317 21 that that WDT cord-010119-t1x9gknd 5317 22 would would MD cord-010119-t1x9gknd 5317 23 be be VB cord-010119-t1x9gknd 5317 24 drawn draw VBN cord-010119-t1x9gknd 5317 25 to to TO cord-010119-t1x9gknd 5317 26 perform perform VB cord-010119-t1x9gknd 5317 27 an an DT cord-010119-t1x9gknd 5317 28 antibody antibody NN cord-010119-t1x9gknd 5317 29 screen screen NN cord-010119-t1x9gknd 5317 30 , , , cord-010119-t1x9gknd 5317 31 we -PRON- PRP cord-010119-t1x9gknd 5317 32 calculated calculate VBD cord-010119-t1x9gknd 5317 33 the the DT cord-010119-t1x9gknd 5317 34 percent percent NN cord-010119-t1x9gknd 5317 35 of of IN cord-010119-t1x9gknd 5317 36 an an DT cord-010119-t1x9gknd 5317 37 infant infant NN cord-010119-t1x9gknd 5317 38 's 's POS cord-010119-t1x9gknd 5317 39 blood blood NN cord-010119-t1x9gknd 5317 40 that that WDT cord-010119-t1x9gknd 5317 41 would would MD cord-010119-t1x9gknd 5317 42 have have VB cord-010119-t1x9gknd 5317 43 to to TO cord-010119-t1x9gknd 5317 44 be be VB cord-010119-t1x9gknd 5317 45 drawn draw VBN cord-010119-t1x9gknd 5317 46 if if IN cord-010119-t1x9gknd 5317 47 the the DT cord-010119-t1x9gknd 5317 48 cord cord NN cord-010119-t1x9gknd 5317 49 blood blood NN cord-010119-t1x9gknd 5317 50 pathway pathway NN cord-010119-t1x9gknd 5317 51 was be VBD cord-010119-t1x9gknd 5317 52 not not RB cord-010119-t1x9gknd 5317 53 established establish VBN cord-010119-t1x9gknd 5317 54 . . . cord-010119-t1x9gknd 5318 1 TRANSFUSION transfusion NN cord-010119-t1x9gknd 5318 2 Results result NNS cord-010119-t1x9gknd 5319 1 /Finding /finde VBG cord-010119-t1x9gknd 5319 2 : : : cord-010119-t1x9gknd 5320 1 In in IN cord-010119-t1x9gknd 5320 2 2016 2016 CD cord-010119-t1x9gknd 5320 3 , , , cord-010119-t1x9gknd 5320 4 there there EX cord-010119-t1x9gknd 5320 5 was be VBD cord-010119-t1x9gknd 5320 6 a a DT cord-010119-t1x9gknd 5320 7 total total NN cord-010119-t1x9gknd 5320 8 of of IN cord-010119-t1x9gknd 5320 9 3,331 3,331 CD cord-010119-t1x9gknd 5320 10 infants infant NNS cord-010119-t1x9gknd 5320 11 delivered deliver VBN cord-010119-t1x9gknd 5320 12 at at IN cord-010119-t1x9gknd 5320 13 our -PRON- PRP$ cord-010119-t1x9gknd 5320 14 facility facility NN cord-010119-t1x9gknd 5320 15 . . . cord-010119-t1x9gknd 5321 1 Out out IN cord-010119-t1x9gknd 5321 2 of of IN cord-010119-t1x9gknd 5321 3 all all PDT cord-010119-t1x9gknd 5321 4 the the DT cord-010119-t1x9gknd 5321 5 deliveries delivery NNS cord-010119-t1x9gknd 5321 6 , , , cord-010119-t1x9gknd 5321 7 487 487 CD cord-010119-t1x9gknd 5321 8 ( ( -LRB- cord-010119-t1x9gknd 5321 9 14 14 CD cord-010119-t1x9gknd 5321 10 % % NN cord-010119-t1x9gknd 5321 11 ) ) -RRB- cord-010119-t1x9gknd 5321 12 infants infant NNS cord-010119-t1x9gknd 5321 13 were be VBD cord-010119-t1x9gknd 5321 14 transferred transfer VBN cord-010119-t1x9gknd 5321 15 to to IN cord-010119-t1x9gknd 5321 16 the the DT cord-010119-t1x9gknd 5321 17 NICU NICU NNP cord-010119-t1x9gknd 5321 18 . . . cord-010119-t1x9gknd 5322 1 Of of IN cord-010119-t1x9gknd 5322 2 those those DT cord-010119-t1x9gknd 5322 3 infants infant NNS cord-010119-t1x9gknd 5322 4 , , , cord-010119-t1x9gknd 5322 5 27 27 CD cord-010119-t1x9gknd 5322 6 % % NN cord-010119-t1x9gknd 5322 7 received receive VBN cord-010119-t1x9gknd 5322 8 at at RB cord-010119-t1x9gknd 5322 9 least least RBS cord-010119-t1x9gknd 5322 10 one one CD cord-010119-t1x9gknd 5322 11 red red JJ cord-010119-t1x9gknd 5322 12 blood blood NN cord-010119-t1x9gknd 5322 13 cell cell NN cord-010119-t1x9gknd 5322 14 transfusion transfusion NN cord-010119-t1x9gknd 5322 15 and and CC cord-010119-t1x9gknd 5322 16 7 7 CD cord-010119-t1x9gknd 5322 17 % % NN cord-010119-t1x9gknd 5322 18 received receive VBN cord-010119-t1x9gknd 5322 19 at at RB cord-010119-t1x9gknd 5322 20 least least RBS cord-010119-t1x9gknd 5322 21 one one CD cord-010119-t1x9gknd 5322 22 platelet platelet NN cord-010119-t1x9gknd 5322 23 transfusion transfusion NN cord-010119-t1x9gknd 5322 24 . . . cord-010119-t1x9gknd 5323 1 Of of IN cord-010119-t1x9gknd 5323 2 the the DT cord-010119-t1x9gknd 5323 3 487 487 CD cord-010119-t1x9gknd 5323 4 infants infant NNS cord-010119-t1x9gknd 5323 5 transferred transfer VBN cord-010119-t1x9gknd 5323 6 to to IN cord-010119-t1x9gknd 5323 7 the the DT cord-010119-t1x9gknd 5323 8 NICU NICU NNP cord-010119-t1x9gknd 5323 9 , , , cord-010119-t1x9gknd 5323 10 98 98 CD cord-010119-t1x9gknd 5323 11 ( ( -LRB- cord-010119-t1x9gknd 5323 12 20 20 CD cord-010119-t1x9gknd 5323 13 % % NN cord-010119-t1x9gknd 5323 14 ) ) -RRB- cord-010119-t1x9gknd 5323 15 had have VBD cord-010119-t1x9gknd 5323 16 a a DT cord-010119-t1x9gknd 5323 17 percentage percentage NN cord-010119-t1x9gknd 5323 18 of of IN cord-010119-t1x9gknd 5323 19 blood blood NN cord-010119-t1x9gknd 5323 20 volume volume NN cord-010119-t1x9gknd 5323 21 that that WDT cord-010119-t1x9gknd 5323 22 would would MD cord-010119-t1x9gknd 5323 23 have have VB cord-010119-t1x9gknd 5323 24 had have VBN cord-010119-t1x9gknd 5323 25 to to TO cord-010119-t1x9gknd 5323 26 be be VB cord-010119-t1x9gknd 5323 27 drawn draw VBN cord-010119-t1x9gknd 5323 28 for for IN cord-010119-t1x9gknd 5323 29 blood blood NN cord-010119-t1x9gknd 5323 30 bank bank NN cord-010119-t1x9gknd 5323 31 testing test VBG cord-010119-t1x9gknd 5323 32 greater great JJR cord-010119-t1x9gknd 5323 33 than than IN cord-010119-t1x9gknd 5323 34 or or CC cord-010119-t1x9gknd 5323 35 equal equal JJ cord-010119-t1x9gknd 5323 36 to to IN cord-010119-t1x9gknd 5323 37 1 1 CD cord-010119-t1x9gknd 5323 38 % % NN cord-010119-t1x9gknd 5323 39 ( ( -LRB- cord-010119-t1x9gknd 5323 40 which which WDT cord-010119-t1x9gknd 5323 41 we -PRON- PRP cord-010119-t1x9gknd 5323 42 considered consider VBD cord-010119-t1x9gknd 5323 43 to to TO cord-010119-t1x9gknd 5323 44 be be VB cord-010119-t1x9gknd 5323 45 significant significant JJ cord-010119-t1x9gknd 5323 46 ) ) -RRB- cord-010119-t1x9gknd 5323 47 , , , cord-010119-t1x9gknd 5323 48 had have VBD cord-010119-t1x9gknd 5323 49 the the DT cord-010119-t1x9gknd 5323 50 cord cord NN cord-010119-t1x9gknd 5323 51 blood blood NN cord-010119-t1x9gknd 5323 52 pathway pathway NN cord-010119-t1x9gknd 5323 53 not not RB cord-010119-t1x9gknd 5323 54 been be VBN cord-010119-t1x9gknd 5323 55 in in IN cord-010119-t1x9gknd 5323 56 effect effect NN cord-010119-t1x9gknd 5323 57 . . . cord-010119-t1x9gknd 5324 1 The the DT cord-010119-t1x9gknd 5324 2 percentage percentage NN cord-010119-t1x9gknd 5324 3 of of IN cord-010119-t1x9gknd 5324 4 blood blood NN cord-010119-t1x9gknd 5324 5 volume volume NN cord-010119-t1x9gknd 5324 6 preserved preserve VBN cord-010119-t1x9gknd 5324 7 in in IN cord-010119-t1x9gknd 5324 8 these these DT cord-010119-t1x9gknd 5324 9 infants infant NNS cord-010119-t1x9gknd 5324 10 ranged range VBD cord-010119-t1x9gknd 5324 11 from from IN cord-010119-t1x9gknd 5324 12 1.0 1.0 CD cord-010119-t1x9gknd 5324 13 % % NN cord-010119-t1x9gknd 5324 14 all all PDT cord-010119-t1x9gknd 5324 15 the the DT cord-010119-t1x9gknd 5324 16 way way NN cord-010119-t1x9gknd 5324 17 up up IN cord-010119-t1x9gknd 5324 18 to to TO cord-010119-t1x9gknd 5324 19 3.9 3.9 CD cord-010119-t1x9gknd 5324 20 % % NN cord-010119-t1x9gknd 5324 21 . . . cord-010119-t1x9gknd 5325 1 In in IN cord-010119-t1x9gknd 5325 2 those those DT cord-010119-t1x9gknd 5325 3 98 98 CD cord-010119-t1x9gknd 5325 4 infants infant NNS cord-010119-t1x9gknd 5325 5 , , , cord-010119-t1x9gknd 5325 6 the the DT cord-010119-t1x9gknd 5325 7 birth birth NN cord-010119-t1x9gknd 5325 8 weight weight NN cord-010119-t1x9gknd 5325 9 ranged range VBD cord-010119-t1x9gknd 5325 10 from from IN cord-010119-t1x9gknd 5325 11 400 400 CD cord-010119-t1x9gknd 5325 12 - - SYM cord-010119-t1x9gknd 5325 13 1650 1650 CD cord-010119-t1x9gknd 5325 14 grams gram NNS cord-010119-t1x9gknd 5325 15 , , , cord-010119-t1x9gknd 5325 16 and and CC cord-010119-t1x9gknd 5325 17 the the DT cord-010119-t1x9gknd 5325 18 gestational gestational JJ cord-010119-t1x9gknd 5325 19 age age NN cord-010119-t1x9gknd 5325 20 ranged range VBD cord-010119-t1x9gknd 5325 21 from from IN cord-010119-t1x9gknd 5325 22 22 22 CD cord-010119-t1x9gknd 5325 23 weeks week NNS cord-010119-t1x9gknd 5325 24 to to IN cord-010119-t1x9gknd 5325 25 36 36 CD cord-010119-t1x9gknd 5325 26 weeks week NNS cord-010119-t1x9gknd 5325 27 and and CC cord-010119-t1x9gknd 5325 28 4 4 CD cord-010119-t1x9gknd 5325 29 days day NNS cord-010119-t1x9gknd 5325 30 . . . cord-010119-t1x9gknd 5326 1 Conclusion conclusion NN cord-010119-t1x9gknd 5326 2 : : : cord-010119-t1x9gknd 5327 1 The the DT cord-010119-t1x9gknd 5327 2 established establish VBN cord-010119-t1x9gknd 5327 3 cord cord NN cord-010119-t1x9gknd 5327 4 blood blood NN cord-010119-t1x9gknd 5327 5 pathway pathway NN cord-010119-t1x9gknd 5327 6 has have VBZ cord-010119-t1x9gknd 5327 7 proven prove VBN cord-010119-t1x9gknd 5327 8 to to TO cord-010119-t1x9gknd 5327 9 be be VB cord-010119-t1x9gknd 5327 10 a a DT cord-010119-t1x9gknd 5327 11 relatively relatively RB cord-010119-t1x9gknd 5327 12 cost cost NN cord-010119-t1x9gknd 5327 13 - - HYPH cord-010119-t1x9gknd 5327 14 effective effective JJ cord-010119-t1x9gknd 5327 15 method method NN cord-010119-t1x9gknd 5327 16 to to TO cord-010119-t1x9gknd 5327 17 prevent prevent VB cord-010119-t1x9gknd 5327 18 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 5327 19 blood blood NN cord-010119-t1x9gknd 5327 20 loss loss NN cord-010119-t1x9gknd 5327 21 secondary secondary JJ cord-010119-t1x9gknd 5327 22 to to IN cord-010119-t1x9gknd 5327 23 blood blood NN cord-010119-t1x9gknd 5327 24 bank bank NN cord-010119-t1x9gknd 5327 25 testing testing NN cord-010119-t1x9gknd 5327 26 in in IN cord-010119-t1x9gknd 5327 27 a a DT cord-010119-t1x9gknd 5327 28 population population NN cord-010119-t1x9gknd 5327 29 of of IN cord-010119-t1x9gknd 5327 30 NICU NICU NNP cord-010119-t1x9gknd 5327 31 infants infant NNS cord-010119-t1x9gknd 5327 32 who who WP cord-010119-t1x9gknd 5327 33 are be VBP cord-010119-t1x9gknd 5327 34 most most RBS cord-010119-t1x9gknd 5327 35 susceptible susceptible JJ cord-010119-t1x9gknd 5327 36 to to IN cord-010119-t1x9gknd 5327 37 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 5327 38 anemia anemia NN cord-010119-t1x9gknd 5327 39 . . . cord-010119-t1x9gknd 5328 1 The the DT cord-010119-t1x9gknd 5328 2 infants infant NNS cord-010119-t1x9gknd 5328 3 that that WDT cord-010119-t1x9gknd 5328 4 were be VBD cord-010119-t1x9gknd 5328 5 most most RBS cord-010119-t1x9gknd 5328 6 likely likely JJ cord-010119-t1x9gknd 5328 7 to to TO cord-010119-t1x9gknd 5328 8 benefit benefit VB cord-010119-t1x9gknd 5328 9 from from IN cord-010119-t1x9gknd 5328 10 this this DT cord-010119-t1x9gknd 5328 11 policy policy NN cord-010119-t1x9gknd 5328 12 are be VBP cord-010119-t1x9gknd 5328 13 premature premature JJ cord-010119-t1x9gknd 5328 14 infants infant NNS cord-010119-t1x9gknd 5328 15 who who WP cord-010119-t1x9gknd 5328 16 are be VBP cord-010119-t1x9gknd 5328 17 low low JJ cord-010119-t1x9gknd 5328 18 birth birth NN cord-010119-t1x9gknd 5328 19 weight weight NN cord-010119-t1x9gknd 5328 20 ( ( -LRB- cord-010119-t1x9gknd 5328 21 less less JJR cord-010119-t1x9gknd 5328 22 than than IN cord-010119-t1x9gknd 5328 23 2500 2500 CD cord-010119-t1x9gknd 5328 24 grams gram NNS cord-010119-t1x9gknd 5328 25 ) ) -RRB- cord-010119-t1x9gknd 5328 26 . . . cord-010119-t1x9gknd 5329 1 Development development NN cord-010119-t1x9gknd 5329 2 of of IN cord-010119-t1x9gknd 5329 3 a a DT cord-010119-t1x9gknd 5329 4 Standardized Standardized NNP cord-010119-t1x9gknd 5329 5 Response Response NNP cord-010119-t1x9gknd 5329 6 Team Team NNP cord-010119-t1x9gknd 5329 7 for for IN cord-010119-t1x9gknd 5329 8 Massive Massive NNP cord-010119-t1x9gknd 5329 9 Hemorrhage Hemorrhage NNP cord-010119-t1x9gknd 5329 10 Events event NNS cord-010119-t1x9gknd 5329 11 Outside outside IN cord-010119-t1x9gknd 5329 12 of of IN cord-010119-t1x9gknd 5329 13 an an DT cord-010119-t1x9gknd 5329 14 Operating operating NN cord-010119-t1x9gknd 5329 15 Room room NN cord-010119-t1x9gknd 5329 16 Setting Setting NNP cord-010119-t1x9gknd 5329 17 James James NNP cord-010119-t1x9gknd 5329 18 Burner Burner NNP cord-010119-t1x9gknd 5329 19 * * NFP cord-010119-t1x9gknd 5329 20 1 1 CD cord-010119-t1x9gknd 5329 21 , , , cord-010119-t1x9gknd 5329 22 Shannon Shannon NNP cord-010119-t1x9gknd 5329 23 Davis Davis NNP cord-010119-t1x9gknd 5329 24 2 2 CD cord-010119-t1x9gknd 5329 25 , , , cord-010119-t1x9gknd 5329 26 Suzan Suzan NNP cord-010119-t1x9gknd 5329 27 New New NNP cord-010119-t1x9gknd 5329 28 2 2 CD cord-010119-t1x9gknd 5329 29 , , , cord-010119-t1x9gknd 5329 30 Vaishali Vaishali NNP cord-010119-t1x9gknd 5329 31 Patel Patel NNP cord-010119-t1x9gknd 5329 32 2 2 CD cord-010119-t1x9gknd 5329 33 and and CC cord-010119-t1x9gknd 5329 34 Oren Oren NNP cord-010119-t1x9gknd 5329 35 Guttman Guttman NNP cord-010119-t1x9gknd 5329 36 2 2 CD cord-010119-t1x9gknd 5329 37 . . . cord-010119-t1x9gknd 5330 1 1 1 CD cord-010119-t1x9gknd 5330 2 University University NNP cord-010119-t1x9gknd 5330 3 of of IN cord-010119-t1x9gknd 5330 4 Texas Texas NNP cord-010119-t1x9gknd 5330 5 Southwestern Southwestern NNP cord-010119-t1x9gknd 5330 6 Medical Medical NNP cord-010119-t1x9gknd 5330 7 Center Center NNP cord-010119-t1x9gknd 5330 8 , , , cord-010119-t1x9gknd 5330 9 2 2 CD cord-010119-t1x9gknd 5330 10 UT UT NNP cord-010119-t1x9gknd 5330 11 Southwestern Southwestern NNP cord-010119-t1x9gknd 5330 12 Medical Medical NNP cord-010119-t1x9gknd 5330 13 Center Center NNP cord-010119-t1x9gknd 5330 14 Background Background NNP cord-010119-t1x9gknd 5330 15 / / SYM cord-010119-t1x9gknd 5330 16 Case Case NNP cord-010119-t1x9gknd 5330 17 Studies Studies NNPS cord-010119-t1x9gknd 5330 18 : : : cord-010119-t1x9gknd 5330 19 Managing manage VBG cord-010119-t1x9gknd 5330 20 a a DT cord-010119-t1x9gknd 5330 21 massive massive JJ cord-010119-t1x9gknd 5330 22 transfusion transfusion NN cord-010119-t1x9gknd 5330 23 protocol protocol NN cord-010119-t1x9gknd 5330 24 ( ( -LRB- cord-010119-t1x9gknd 5330 25 MTP MTP NNP cord-010119-t1x9gknd 5330 26 ) ) -RRB- cord-010119-t1x9gknd 5330 27 in in IN cord-010119-t1x9gknd 5330 28 an an DT cord-010119-t1x9gknd 5330 29 operating operating NN cord-010119-t1x9gknd 5330 30 room room NN cord-010119-t1x9gknd 5330 31 ( ( -LRB- cord-010119-t1x9gknd 5330 32 OR OR NNP cord-010119-t1x9gknd 5330 33 ) ) -RRB- cord-010119-t1x9gknd 5330 34 is be VBZ cord-010119-t1x9gknd 5330 35 a a DT cord-010119-t1x9gknd 5330 36 relatively relatively RB cord-010119-t1x9gknd 5330 37 frequent frequent JJ cord-010119-t1x9gknd 5330 38 occurrence occurrence NN cord-010119-t1x9gknd 5330 39 with with IN cord-010119-t1x9gknd 5330 40 team team NN cord-010119-t1x9gknd 5330 41 members member NNS cord-010119-t1x9gknd 5330 42 well well RB cord-010119-t1x9gknd 5330 43 trained train VBN cord-010119-t1x9gknd 5330 44 in in IN cord-010119-t1x9gknd 5330 45 their -PRON- PRP$ cord-010119-t1x9gknd 5330 46 specific specific JJ cord-010119-t1x9gknd 5330 47 roles role NNS cord-010119-t1x9gknd 5330 48 . . . cord-010119-t1x9gknd 5331 1 However however RB cord-010119-t1x9gknd 5331 2 , , , cord-010119-t1x9gknd 5331 3 in in IN cord-010119-t1x9gknd 5331 4 the the DT cord-010119-t1x9gknd 5331 5 event event NN cord-010119-t1x9gknd 5331 6 of of IN cord-010119-t1x9gknd 5331 7 MTP MTP NNP cord-010119-t1x9gknd 5331 8 activation activation NN cord-010119-t1x9gknd 5331 9 outside outside IN cord-010119-t1x9gknd 5331 10 of of IN cord-010119-t1x9gknd 5331 11 an an DT cord-010119-t1x9gknd 5331 12 OR or NN cord-010119-t1x9gknd 5331 13 , , , cord-010119-t1x9gknd 5331 14 sufficient sufficient JJ cord-010119-t1x9gknd 5331 15 and/or and/or CC cord-010119-t1x9gknd 5331 16 appropriately appropriately RB cord-010119-t1x9gknd 5331 17 trained train VBN cord-010119-t1x9gknd 5331 18 individuals individual NNS cord-010119-t1x9gknd 5331 19 may may MD cord-010119-t1x9gknd 5331 20 not not RB cord-010119-t1x9gknd 5331 21 be be VB cord-010119-t1x9gknd 5331 22 present present JJ cord-010119-t1x9gknd 5331 23 . . . cord-010119-t1x9gknd 5332 1 This this DT cord-010119-t1x9gknd 5332 2 can can MD cord-010119-t1x9gknd 5332 3 lead lead VB cord-010119-t1x9gknd 5332 4 to to IN cord-010119-t1x9gknd 5332 5 a a DT cord-010119-t1x9gknd 5332 6 scene scene NN cord-010119-t1x9gknd 5332 7 of of IN cord-010119-t1x9gknd 5332 8 confusion confusion NN cord-010119-t1x9gknd 5332 9 and and CC cord-010119-t1x9gknd 5332 10 chaos chaos NN cord-010119-t1x9gknd 5332 11 with with IN cord-010119-t1x9gknd 5332 12 potential potential NN cord-010119-t1x9gknd 5332 13 for for IN cord-010119-t1x9gknd 5332 14 patient patient JJ cord-010119-t1x9gknd 5332 15 harm harm NN cord-010119-t1x9gknd 5332 16 . . . cord-010119-t1x9gknd 5333 1 Study Study NNP cord-010119-t1x9gknd 5333 2 Design Design NNP cord-010119-t1x9gknd 5333 3 / / SYM cord-010119-t1x9gknd 5333 4 Method method NN cord-010119-t1x9gknd 5333 5 : : : cord-010119-t1x9gknd 5334 1 A a DT cord-010119-t1x9gknd 5334 2 Failure failure NN cord-010119-t1x9gknd 5334 3 Mode Mode NNP cord-010119-t1x9gknd 5334 4 Effects Effects NNPS cord-010119-t1x9gknd 5334 5 Analysis Analysis NNP cord-010119-t1x9gknd 5334 6 was be VBD cord-010119-t1x9gknd 5334 7 performed perform VBN cord-010119-t1x9gknd 5334 8 to to TO cord-010119-t1x9gknd 5334 9 develop develop VB cord-010119-t1x9gknd 5334 10 a a DT cord-010119-t1x9gknd 5334 11 standardized standardized JJ cord-010119-t1x9gknd 5334 12 process process NN cord-010119-t1x9gknd 5334 13 for for IN cord-010119-t1x9gknd 5334 14 managing manage VBG cord-010119-t1x9gknd 5334 15 MTP MTP NNP cord-010119-t1x9gknd 5334 16 outside outside IN cord-010119-t1x9gknd 5334 17 of of IN cord-010119-t1x9gknd 5334 18 an an DT cord-010119-t1x9gknd 5334 19 OR or JJ cord-010119-t1x9gknd 5334 20 setting setting NN cord-010119-t1x9gknd 5334 21 . . . cord-010119-t1x9gknd 5335 1 With with IN cord-010119-t1x9gknd 5335 2 participation participation NN cord-010119-t1x9gknd 5335 3 from from IN cord-010119-t1x9gknd 5335 4 anesthesia anesthesia NN cord-010119-t1x9gknd 5335 5 , , , cord-010119-t1x9gknd 5335 6 surgery surgery NN cord-010119-t1x9gknd 5335 7 , , , cord-010119-t1x9gknd 5335 8 transfusion transfusion NN cord-010119-t1x9gknd 5335 9 medicine medicine NN cord-010119-t1x9gknd 5335 10 , , , cord-010119-t1x9gknd 5335 11 patient patient JJ cord-010119-t1x9gknd 5335 12 safety safety NN cord-010119-t1x9gknd 5335 13 and and CC cord-010119-t1x9gknd 5335 14 quality quality NN cord-010119-t1x9gknd 5335 15 and and CC cord-010119-t1x9gknd 5335 16 nursing nursing NN cord-010119-t1x9gknd 5335 17 , , , cord-010119-t1x9gknd 5335 18 every every DT cord-010119-t1x9gknd 5335 19 step step NN cord-010119-t1x9gknd 5335 20 of of IN cord-010119-t1x9gknd 5335 21 the the DT cord-010119-t1x9gknd 5335 22 hospital hospital NN cord-010119-t1x9gknd 5335 23 's 's POS cord-010119-t1x9gknd 5335 24 MTP MTP NNP cord-010119-t1x9gknd 5335 25 was be VBD cord-010119-t1x9gknd 5335 26 analyzed analyze VBN cord-010119-t1x9gknd 5335 27 for for IN cord-010119-t1x9gknd 5335 28 potential potential JJ cord-010119-t1x9gknd 5335 29 errors error NNS cord-010119-t1x9gknd 5335 30 . . . cord-010119-t1x9gknd 5336 1 The the DT cord-010119-t1x9gknd 5336 2 results result NNS cord-010119-t1x9gknd 5336 3 were be VBD cord-010119-t1x9gknd 5336 4 used use VBN cord-010119-t1x9gknd 5336 5 to to TO cord-010119-t1x9gknd 5336 6 create create VB cord-010119-t1x9gknd 5336 7 a a DT cord-010119-t1x9gknd 5336 8 " " `` cord-010119-t1x9gknd 5336 9 code code NN cord-010119-t1x9gknd 5336 10 hemorrhage hemorrhage NN cord-010119-t1x9gknd 5336 11 " " '' cord-010119-t1x9gknd 5336 12 team team NN cord-010119-t1x9gknd 5336 13 trained train VBN cord-010119-t1x9gknd 5336 14 to to TO cord-010119-t1x9gknd 5336 15 respond respond VB cord-010119-t1x9gknd 5336 16 to to IN cord-010119-t1x9gknd 5336 17 any any DT cord-010119-t1x9gknd 5336 18 massively massively RB cord-010119-t1x9gknd 5336 19 hemorrhaging hemorrhage VBG cord-010119-t1x9gknd 5336 20 non non JJ cord-010119-t1x9gknd 5336 21 - - JJ cord-010119-t1x9gknd 5336 22 OR or JJ cord-010119-t1x9gknd 5336 23 patient patient NN cord-010119-t1x9gknd 5336 24 . . . cord-010119-t1x9gknd 5337 1 Results/ Results/ . cord-010119-t1x9gknd 5338 1 Finding finding NN cord-010119-t1x9gknd 5338 2 : : : cord-010119-t1x9gknd 5339 1 Code Code NNP cord-010119-t1x9gknd 5339 2 Hemorrhage Hemorrhage NNP cord-010119-t1x9gknd 5339 3 represents represent VBZ cord-010119-t1x9gknd 5339 4 a a DT cord-010119-t1x9gknd 5339 5 multi multi JJ cord-010119-t1x9gknd 5339 6 - - JJ cord-010119-t1x9gknd 5339 7 system system JJ cord-010119-t1x9gknd 5339 8 team team NN cord-010119-t1x9gknd 5339 9 critical critical JJ cord-010119-t1x9gknd 5339 10 event event NN cord-010119-t1x9gknd 5339 11 requiring require VBG cord-010119-t1x9gknd 5339 12 coordination coordination NN cord-010119-t1x9gknd 5339 13 of of IN cord-010119-t1x9gknd 5339 14 different different JJ cord-010119-t1x9gknd 5339 15 sub sub NN cord-010119-t1x9gknd 5339 16 - - NNS cord-010119-t1x9gknd 5339 17 teams team NNS cord-010119-t1x9gknd 5339 18 ( ( -LRB- cord-010119-t1x9gknd 5339 19 primary primary JJ cord-010119-t1x9gknd 5339 20 resuscitation resuscitation NN cord-010119-t1x9gknd 5339 21 , , , cord-010119-t1x9gknd 5339 22 surgical surgical JJ cord-010119-t1x9gknd 5339 23 / / SYM cord-010119-t1x9gknd 5339 24 interventional interventional JJ cord-010119-t1x9gknd 5339 25 , , , cord-010119-t1x9gknd 5339 26 transfusion transfusion NN cord-010119-t1x9gknd 5339 27 services service NNS cord-010119-t1x9gknd 5339 28 , , , cord-010119-t1x9gknd 5339 29 blood blood NN cord-010119-t1x9gknd 5339 30 preparation preparation NN cord-010119-t1x9gknd 5339 31 , , , cord-010119-t1x9gknd 5339 32 equipment equipment NN cord-010119-t1x9gknd 5339 33 management management NN cord-010119-t1x9gknd 5339 34 , , , cord-010119-t1x9gknd 5339 35 medication medication NN cord-010119-t1x9gknd 5339 36 management management NN cord-010119-t1x9gknd 5339 37 , , , cord-010119-t1x9gknd 5339 38 and and CC cord-010119-t1x9gknd 5339 39 lab lab NN cord-010119-t1x9gknd 5339 40 requisition requisition NN cord-010119-t1x9gknd 5339 41 / / SYM cord-010119-t1x9gknd 5339 42 monitoring monitoring NN cord-010119-t1x9gknd 5339 43 ) ) -RRB- cord-010119-t1x9gknd 5339 44 . . . cord-010119-t1x9gknd 5340 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5340 2 Code Code NNP cord-010119-t1x9gknd 5340 3 Hemorrhage Hemorrhage NNP cord-010119-t1x9gknd 5340 4 protocol protocol NN cord-010119-t1x9gknd 5340 5 utilizes utilize VBZ cord-010119-t1x9gknd 5340 6 critical critical JJ cord-010119-t1x9gknd 5340 7 care care NN cord-010119-t1x9gknd 5340 8 trained train VBN cord-010119-t1x9gknd 5340 9 nurses nurse NNS cord-010119-t1x9gknd 5340 10 from from IN cord-010119-t1x9gknd 5340 11 the the DT cord-010119-t1x9gknd 5340 12 hospital hospital NN cord-010119-t1x9gknd 5340 13 's 's POS cord-010119-t1x9gknd 5340 14 rapid rapid JJ cord-010119-t1x9gknd 5340 15 response response NN cord-010119-t1x9gknd 5340 16 team team NN cord-010119-t1x9gknd 5340 17 who who WP cord-010119-t1x9gknd 5340 18 play play VBP cord-010119-t1x9gknd 5340 19 two two CD cord-010119-t1x9gknd 5340 20 key key JJ cord-010119-t1x9gknd 5340 21 new new JJ cord-010119-t1x9gknd 5340 22 coordination coordination NN cord-010119-t1x9gknd 5340 23 roles role NNS cord-010119-t1x9gknd 5340 24 : : : cord-010119-t1x9gknd 5340 25 hemorrhage hemorrhage NN cord-010119-t1x9gknd 5340 26 coordinator coordinator NN cord-010119-t1x9gknd 5340 27 and and CC cord-010119-t1x9gknd 5340 28 electronic electronic JJ cord-010119-t1x9gknd 5340 29 medical medical JJ cord-010119-t1x9gknd 5340 30 record record NN cord-010119-t1x9gknd 5340 31 ( ( -LRB- cord-010119-t1x9gknd 5340 32 EMR EMR NNP cord-010119-t1x9gknd 5340 33 ) ) -RRB- cord-010119-t1x9gknd 5340 34 coordinator coordinator NN cord-010119-t1x9gknd 5340 35 . . . cord-010119-t1x9gknd 5341 1 Their -PRON- PRP$ cord-010119-t1x9gknd 5341 2 combined combine VBN cord-010119-t1x9gknd 5341 3 roles role NNS cord-010119-t1x9gknd 5341 4 serve serve VBP cord-010119-t1x9gknd 5341 5 to to TO cord-010119-t1x9gknd 5341 6 reduce reduce VB cord-010119-t1x9gknd 5341 7 the the DT cord-010119-t1x9gknd 5341 8 cognitive cognitive JJ cord-010119-t1x9gknd 5341 9 load load NN cord-010119-t1x9gknd 5341 10 of of IN cord-010119-t1x9gknd 5341 11 the the DT cord-010119-t1x9gknd 5341 12 various various JJ cord-010119-t1x9gknd 5341 13 teams team NNS cord-010119-t1x9gknd 5341 14 , , , cord-010119-t1x9gknd 5341 15 prevent prevent VB cord-010119-t1x9gknd 5341 16 duplication duplication NN cord-010119-t1x9gknd 5341 17 of of IN cord-010119-t1x9gknd 5341 18 resources resource NNS cord-010119-t1x9gknd 5341 19 / / SYM cord-010119-t1x9gknd 5341 20 efforts effort NNS cord-010119-t1x9gknd 5341 21 during during IN cord-010119-t1x9gknd 5341 22 MTP MTP NNP cord-010119-t1x9gknd 5341 23 and and CC cord-010119-t1x9gknd 5341 24 enable enable VB cord-010119-t1x9gknd 5341 25 enhanced enhance VBN cord-010119-t1x9gknd 5341 26 closed closed JJ cord-010119-t1x9gknd 5341 27 loop loop NN cord-010119-t1x9gknd 5341 28 task task NN cord-010119-t1x9gknd 5341 29 performance performance NN cord-010119-t1x9gknd 5341 30 . . . cord-010119-t1x9gknd 5342 1 The the DT cord-010119-t1x9gknd 5342 2 hemorrhage hemorrhage NN cord-010119-t1x9gknd 5342 3 coordinator coordinator NN cord-010119-t1x9gknd 5342 4 establishes establish VBZ cord-010119-t1x9gknd 5342 5 reliable reliable JJ cord-010119-t1x9gknd 5342 6 1:1 1:1 CD cord-010119-t1x9gknd 5342 7 communication communication NN cord-010119-t1x9gknd 5342 8 between between IN cord-010119-t1x9gknd 5342 9 the the DT cord-010119-t1x9gknd 5342 10 primary primary JJ cord-010119-t1x9gknd 5342 11 resuscitation resuscitation NN cord-010119-t1x9gknd 5342 12 team team NN cord-010119-t1x9gknd 5342 13 and and CC cord-010119-t1x9gknd 5342 14 transfusion transfusion NN cord-010119-t1x9gknd 5342 15 services service NNS cord-010119-t1x9gknd 5342 16 , , , cord-010119-t1x9gknd 5342 17 and and CC cord-010119-t1x9gknd 5342 18 aids aids NNP cord-010119-t1x9gknd 5342 19 in in IN cord-010119-t1x9gknd 5342 20 multi multi JJ cord-010119-t1x9gknd 5342 21 - - JJ cord-010119-t1x9gknd 5342 22 team team NN cord-010119-t1x9gknd 5342 23 on on IN cord-010119-t1x9gknd 5342 24 - - HYPH cord-010119-t1x9gknd 5342 25 site site NN cord-010119-t1x9gknd 5342 26 coordination coordination NN cord-010119-t1x9gknd 5342 27 . . . cord-010119-t1x9gknd 5343 1 The the DT cord-010119-t1x9gknd 5343 2 EMR EMR NNP cord-010119-t1x9gknd 5343 3 coordinator coordinator NN cord-010119-t1x9gknd 5343 4 enters enter VBZ cord-010119-t1x9gknd 5343 5 all all DT cord-010119-t1x9gknd 5343 6 orders order NNS cord-010119-t1x9gknd 5343 7 into into IN cord-010119-t1x9gknd 5343 8 the the DT cord-010119-t1x9gknd 5343 9 EMR EMR NNP cord-010119-t1x9gknd 5343 10 , , , cord-010119-t1x9gknd 5343 11 sends send VBZ cord-010119-t1x9gknd 5343 12 / / SYM cord-010119-t1x9gknd 5343 13 communicates communicate VBZ cord-010119-t1x9gknd 5343 14 laboratory laboratory NN cord-010119-t1x9gknd 5343 15 results result NNS cord-010119-t1x9gknd 5343 16 and and CC cord-010119-t1x9gknd 5343 17 ensures ensure VBZ cord-010119-t1x9gknd 5343 18 blood blood NN cord-010119-t1x9gknd 5343 19 products product NNS cord-010119-t1x9gknd 5343 20 are be VBP cord-010119-t1x9gknd 5343 21 available available JJ cord-010119-t1x9gknd 5343 22 to to IN cord-010119-t1x9gknd 5343 23 the the DT cord-010119-t1x9gknd 5343 24 resuscitation resuscitation NN cord-010119-t1x9gknd 5343 25 team team NN cord-010119-t1x9gknd 5343 26 . . . cord-010119-t1x9gknd 5344 1 The the DT cord-010119-t1x9gknd 5344 2 primary primary JJ cord-010119-t1x9gknd 5344 3 resuscitation resuscitation NN cord-010119-t1x9gknd 5344 4 team team NN cord-010119-t1x9gknd 5344 5 includes include VBZ cord-010119-t1x9gknd 5344 6 a a DT cord-010119-t1x9gknd 5344 7 team team NN cord-010119-t1x9gknd 5344 8 leader leader NN cord-010119-t1x9gknd 5344 9 ( ( -LRB- cord-010119-t1x9gknd 5344 10 medical medical JJ cord-010119-t1x9gknd 5344 11 decision decision NN cord-010119-t1x9gknd 5344 12 making make VBG cord-010119-t1x9gknd 5344 13 and and CC cord-010119-t1x9gknd 5344 14 cardiac cardiac JJ cord-010119-t1x9gknd 5344 15 life life NN cord-010119-t1x9gknd 5344 16 - - HYPH cord-010119-t1x9gknd 5344 17 support support NN cord-010119-t1x9gknd 5344 18 management management NN cord-010119-t1x9gknd 5344 19 ) ) -RRB- cord-010119-t1x9gknd 5344 20 ; ; : cord-010119-t1x9gknd 5344 21 a a DT cord-010119-t1x9gknd 5344 22 proceduralist proceduralist NN cord-010119-t1x9gknd 5344 23 ( ( -LRB- cord-010119-t1x9gknd 5344 24 establishing establish VBG cord-010119-t1x9gknd 5344 25 venous venous JJ cord-010119-t1x9gknd 5344 26 and/or and/or CC cord-010119-t1x9gknd 5344 27 arterial arterial JJ cord-010119-t1x9gknd 5344 28 access access NN cord-010119-t1x9gknd 5344 29 ) ) -RRB- cord-010119-t1x9gknd 5344 30 , , , cord-010119-t1x9gknd 5344 31 event event NN cord-010119-t1x9gknd 5344 32 documenter documenter NN cord-010119-t1x9gknd 5344 33 ( ( -LRB- cord-010119-t1x9gknd 5344 34 real real JJ cord-010119-t1x9gknd 5344 35 - - HYPH cord-010119-t1x9gknd 5344 36 time time NN cord-010119-t1x9gknd 5344 37 documentation documentation NN cord-010119-t1x9gknd 5344 38 of of IN cord-010119-t1x9gknd 5344 39 actions action NNS cord-010119-t1x9gknd 5344 40 , , , cord-010119-t1x9gknd 5344 41 medications medication NNS cord-010119-t1x9gknd 5344 42 , , , cord-010119-t1x9gknd 5344 43 events event NNS cord-010119-t1x9gknd 5344 44 , , , cord-010119-t1x9gknd 5344 45 etc etc FW cord-010119-t1x9gknd 5344 46 . . . cord-010119-t1x9gknd 5344 47 ) ) -RRB- cord-010119-t1x9gknd 5344 48 , , , cord-010119-t1x9gknd 5344 49 medication medication NN cord-010119-t1x9gknd 5344 50 manager manager NN cord-010119-t1x9gknd 5344 51 ( ( -LRB- cord-010119-t1x9gknd 5344 52 registered register VBN cord-010119-t1x9gknd 5344 53 nurse nurse NN cord-010119-t1x9gknd 5344 54 who who WP cord-010119-t1x9gknd 5344 55 prepares prepare VBZ cord-010119-t1x9gknd 5344 56 and and CC cord-010119-t1x9gknd 5344 57 administers administer VBZ cord-010119-t1x9gknd 5344 58 medications medication NNS cord-010119-t1x9gknd 5344 59 ) ) -RRB- cord-010119-t1x9gknd 5344 60 and and CC cord-010119-t1x9gknd 5344 61 equipment equipment NN cord-010119-t1x9gknd 5344 62 technologist technologist NN cord-010119-t1x9gknd 5344 63 ( ( -LRB- cord-010119-t1x9gknd 5344 64 managing manage VBG cord-010119-t1x9gknd 5344 65 rapid rapid JJ cord-010119-t1x9gknd 5344 66 blood blood NN cord-010119-t1x9gknd 5344 67 product product NN cord-010119-t1x9gknd 5344 68 infusion infusion NN cord-010119-t1x9gknd 5344 69 devices device NNS cord-010119-t1x9gknd 5344 70 ) ) -RRB- cord-010119-t1x9gknd 5344 71 . . . cord-010119-t1x9gknd 5345 1 Additional additional JJ cord-010119-t1x9gknd 5345 2 secondary secondary JJ cord-010119-t1x9gknd 5345 3 roles role NNS cord-010119-t1x9gknd 5345 4 will will MD cord-010119-t1x9gknd 5345 5 also also RB cord-010119-t1x9gknd 5345 6 be be VB cord-010119-t1x9gknd 5345 7 assigned assign VBN cord-010119-t1x9gknd 5345 8 , , , cord-010119-t1x9gknd 5345 9 such such JJ cord-010119-t1x9gknd 5345 10 as as IN cord-010119-t1x9gknd 5345 11 blood blood NN cord-010119-t1x9gknd 5345 12 product product NN cord-010119-t1x9gknd 5345 13 checker(s checker(s NN cord-010119-t1x9gknd 5345 14 ) ) -RRB- cord-010119-t1x9gknd 5345 15 ( ( -LRB- cord-010119-t1x9gknd 5345 16 verifies verify VBZ cord-010119-t1x9gknd 5345 17 blood blood NN cord-010119-t1x9gknd 5345 18 product product NN cord-010119-t1x9gknd 5345 19 prior prior RB cord-010119-t1x9gknd 5345 20 to to IN cord-010119-t1x9gknd 5345 21 transfusion transfusion NN cord-010119-t1x9gknd 5345 22 ) ) -RRB- cord-010119-t1x9gknd 5345 23 and and CC cord-010119-t1x9gknd 5345 24 blood blood NN cord-010119-t1x9gknd 5345 25 bank bank NN cord-010119-t1x9gknd 5345 26 runner runner NN cord-010119-t1x9gknd 5345 27 ( ( -LRB- cord-010119-t1x9gknd 5345 28 courier courier NN cord-010119-t1x9gknd 5345 29 sent send VBN cord-010119-t1x9gknd 5345 30 to to IN cord-010119-t1x9gknd 5345 31 retrieves retrieve VBZ cord-010119-t1x9gknd 5345 32 blood blood NN cord-010119-t1x9gknd 5345 33 product product NN cord-010119-t1x9gknd 5345 34 shipments shipment NNS cord-010119-t1x9gknd 5345 35 ) ) -RRB- cord-010119-t1x9gknd 5345 36 . . . cord-010119-t1x9gknd 5346 1 Conclusion conclusion NN cord-010119-t1x9gknd 5346 2 : : : cord-010119-t1x9gknd 5346 3 The the DT cord-010119-t1x9gknd 5346 4 code code NN cord-010119-t1x9gknd 5346 5 hemorrhage hemorrhage NN cord-010119-t1x9gknd 5346 6 protocol protocol NN cord-010119-t1x9gknd 5346 7 is be VBZ cord-010119-t1x9gknd 5346 8 designed design VBN cord-010119-t1x9gknd 5346 9 to to TO cord-010119-t1x9gknd 5346 10 ensure ensure VB cord-010119-t1x9gknd 5346 11 timely timely JJ cord-010119-t1x9gknd 5346 12 , , , cord-010119-t1x9gknd 5346 13 efficient efficient JJ cord-010119-t1x9gknd 5346 14 delivery delivery NN cord-010119-t1x9gknd 5346 15 of of IN cord-010119-t1x9gknd 5346 16 blood blood NN cord-010119-t1x9gknd 5346 17 products product NNS cord-010119-t1x9gknd 5346 18 to to TO cord-010119-t1x9gknd 5346 19 massively massively RB cord-010119-t1x9gknd 5346 20 bleeding bleed VBG cord-010119-t1x9gknd 5346 21 patients patient NNS cord-010119-t1x9gknd 5346 22 outside outside RB cord-010119-t1x9gknd 5346 23 of of IN cord-010119-t1x9gknd 5346 24 an an DT cord-010119-t1x9gknd 5346 25 OR or JJ cord-010119-t1x9gknd 5346 26 setting setting NN cord-010119-t1x9gknd 5346 27 . . . cord-010119-t1x9gknd 5347 1 Future future JJ cord-010119-t1x9gknd 5347 2 work work NN cord-010119-t1x9gknd 5347 3 will will MD cord-010119-t1x9gknd 5347 4 assess assess VB cord-010119-t1x9gknd 5347 5 its -PRON- PRP$ cord-010119-t1x9gknd 5347 6 overall overall JJ cord-010119-t1x9gknd 5347 7 effectiveness effectiveness NN cord-010119-t1x9gknd 5347 8 by by IN cord-010119-t1x9gknd 5347 9 comparing compare VBG cord-010119-t1x9gknd 5347 10 blood blood NN cord-010119-t1x9gknd 5347 11 product product NN cord-010119-t1x9gknd 5347 12 utilization utilization NN cord-010119-t1x9gknd 5347 13 / / SYM cord-010119-t1x9gknd 5347 14 wastage wastage NN cord-010119-t1x9gknd 5347 15 and and CC cord-010119-t1x9gknd 5347 16 patient patient JJ cord-010119-t1x9gknd 5347 17 outcomes outcome NNS cord-010119-t1x9gknd 5347 18 before before IN cord-010119-t1x9gknd 5347 19 and and CC cord-010119-t1x9gknd 5347 20 after after IN cord-010119-t1x9gknd 5347 21 implementation implementation NN cord-010119-t1x9gknd 5347 22 . . . cord-010119-t1x9gknd 5348 1 Background Background NNP cord-010119-t1x9gknd 5348 2 / / SYM cord-010119-t1x9gknd 5348 3 Case Case NNP cord-010119-t1x9gknd 5348 4 Studies Studies NNPS cord-010119-t1x9gknd 5349 1 : : : cord-010119-t1x9gknd 5349 2 Preoperative Preoperative NNP cord-010119-t1x9gknd 5349 3 anemia anemia NN cord-010119-t1x9gknd 5349 4 affects affect VBZ cord-010119-t1x9gknd 5349 5 up up IN cord-010119-t1x9gknd 5349 6 to to TO cord-010119-t1x9gknd 5349 7 50 50 CD cord-010119-t1x9gknd 5349 8 % % NN cord-010119-t1x9gknd 5349 9 of of IN cord-010119-t1x9gknd 5349 10 surgical surgical JJ cord-010119-t1x9gknd 5349 11 patients patient NNS cord-010119-t1x9gknd 5349 12 and and CC cord-010119-t1x9gknd 5349 13 increases increase VBZ cord-010119-t1x9gknd 5349 14 the the DT cord-010119-t1x9gknd 5349 15 risk risk NN cord-010119-t1x9gknd 5349 16 of of IN cord-010119-t1x9gknd 5349 17 red red JJ cord-010119-t1x9gknd 5349 18 blood blood NN cord-010119-t1x9gknd 5349 19 cell cell NN cord-010119-t1x9gknd 5349 20 ( ( -LRB- cord-010119-t1x9gknd 5349 21 RBC RBC NNP cord-010119-t1x9gknd 5349 22 ) ) -RRB- cord-010119-t1x9gknd 5349 23 transfusion transfusion NN cord-010119-t1x9gknd 5349 24 . . . cord-010119-t1x9gknd 5350 1 Both both DT cord-010119-t1x9gknd 5350 2 preoperative preoperative JJ cord-010119-t1x9gknd 5350 3 anemia anemia NN cord-010119-t1x9gknd 5350 4 and and CC cord-010119-t1x9gknd 5350 5 perioperative perioperative JJ cord-010119-t1x9gknd 5350 6 RBC RBC NNP cord-010119-t1x9gknd 5350 7 transfusion transfusion NN cord-010119-t1x9gknd 5350 8 are be VBP cord-010119-t1x9gknd 5350 9 associated associate VBN cord-010119-t1x9gknd 5350 10 with with IN cord-010119-t1x9gknd 5350 11 increased increase VBN cord-010119-t1x9gknd 5350 12 risk risk NN cord-010119-t1x9gknd 5350 13 of of IN cord-010119-t1x9gknd 5350 14 adverse adverse JJ cord-010119-t1x9gknd 5350 15 outcomes outcome NNS cord-010119-t1x9gknd 5350 16 following follow VBG cord-010119-t1x9gknd 5350 17 surgery surgery NN cord-010119-t1x9gknd 5350 18 . . . cord-010119-t1x9gknd 5351 1 Preoperative preoperative JJ cord-010119-t1x9gknd 5351 2 treatment treatment NN cord-010119-t1x9gknd 5351 3 of of IN cord-010119-t1x9gknd 5351 4 anemia anemia NN cord-010119-t1x9gknd 5351 5 includes include VBZ cord-010119-t1x9gknd 5351 6 oral oral JJ cord-010119-t1x9gknd 5351 7 and and CC cord-010119-t1x9gknd 5351 8 intravenous intravenous JJ cord-010119-t1x9gknd 5351 9 ( ( -LRB- cord-010119-t1x9gknd 5351 10 i.v i.v NNP cord-010119-t1x9gknd 5351 11 . . NNP cord-010119-t1x9gknd 5351 12 ) ) -RRB- cord-010119-t1x9gknd 5351 13 iron iron NN cord-010119-t1x9gknd 5351 14 and and CC cord-010119-t1x9gknd 5351 15 erythroid erythroid JJ cord-010119-t1x9gknd 5351 16 stimulating stimulate VBG cord-010119-t1x9gknd 5351 17 agents agent NNS cord-010119-t1x9gknd 5351 18 ( ( -LRB- cord-010119-t1x9gknd 5351 19 ESA ESA NNP cord-010119-t1x9gknd 5351 20 ) ) -RRB- cord-010119-t1x9gknd 5351 21 such such JJ cord-010119-t1x9gknd 5351 22 as as IN cord-010119-t1x9gknd 5351 23 erythropoietin erythropoietin NN cord-010119-t1x9gknd 5351 24 ( ( -LRB- cord-010119-t1x9gknd 5351 25 EPO EPO NNP cord-010119-t1x9gknd 5351 26 ) ) -RRB- cord-010119-t1x9gknd 5351 27 ; ; : cord-010119-t1x9gknd 5351 28 however however RB cord-010119-t1x9gknd 5351 29 , , , cord-010119-t1x9gknd 5351 30 the the DT cord-010119-t1x9gknd 5351 31 optimal optimal JJ cord-010119-t1x9gknd 5351 32 treatment treatment NN cord-010119-t1x9gknd 5351 33 strategy strategy NN cord-010119-t1x9gknd 5351 34 for for IN cord-010119-t1x9gknd 5351 35 preoperative preoperative JJ cord-010119-t1x9gknd 5351 36 anemia anemia NN cord-010119-t1x9gknd 5351 37 remains remain VBZ cord-010119-t1x9gknd 5351 38 to to TO cord-010119-t1x9gknd 5351 39 be be VB cord-010119-t1x9gknd 5351 40 established establish VBN cord-010119-t1x9gknd 5351 41 . . . cord-010119-t1x9gknd 5352 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5352 2 objectives objective NNS cord-010119-t1x9gknd 5352 3 were be VBD cord-010119-t1x9gknd 5352 4 to to TO cord-010119-t1x9gknd 5352 5 evaluate evaluate VB cord-010119-t1x9gknd 5352 6 the the DT cord-010119-t1x9gknd 5352 7 efficacy efficacy NN cord-010119-t1x9gknd 5352 8 and and CC cord-010119-t1x9gknd 5352 9 safety safety NN cord-010119-t1x9gknd 5352 10 of of IN cord-010119-t1x9gknd 5352 11 ESA ESA NNP cord-010119-t1x9gknd 5352 12 and and CC cord-010119-t1x9gknd 5352 13 iron iron NN cord-010119-t1x9gknd 5352 14 therapy therapy NN cord-010119-t1x9gknd 5352 15 based base VBN cord-010119-t1x9gknd 5352 16 on on IN cord-010119-t1x9gknd 5352 17 their -PRON- PRP$ cord-010119-t1x9gknd 5352 18 effects effect NNS cord-010119-t1x9gknd 5352 19 on on IN cord-010119-t1x9gknd 5352 20 the the DT cord-010119-t1x9gknd 5352 21 prevalence prevalence NN cord-010119-t1x9gknd 5352 22 of of IN cord-010119-t1x9gknd 5352 23 RBC RBC NNP cord-010119-t1x9gknd 5352 24 transfusions transfusion NNS cord-010119-t1x9gknd 5352 25 and and CC cord-010119-t1x9gknd 5352 26 adverse adverse JJ cord-010119-t1x9gknd 5352 27 thrombotic thrombotic JJ cord-010119-t1x9gknd 5352 28 events event NNS cord-010119-t1x9gknd 5352 29 . . . cord-010119-t1x9gknd 5353 1 Study Study NNP cord-010119-t1x9gknd 5353 2 Design Design NNP cord-010119-t1x9gknd 5353 3 / / SYM cord-010119-t1x9gknd 5353 4 Method method NN cord-010119-t1x9gknd 5353 5 : : : cord-010119-t1x9gknd 5353 6 We -PRON- PRP cord-010119-t1x9gknd 5353 7 searched search VBD cord-010119-t1x9gknd 5353 8 the the DT cord-010119-t1x9gknd 5353 9 Cochrane Cochrane NNP cord-010119-t1x9gknd 5353 10 Central Central NNP cord-010119-t1x9gknd 5353 11 Register Register NNP cord-010119-t1x9gknd 5353 12 of of IN cord-010119-t1x9gknd 5353 13 Controlled Controlled NNP cord-010119-t1x9gknd 5353 14 Trials Trials NNPS cord-010119-t1x9gknd 5353 15 , , , cord-010119-t1x9gknd 5353 16 MEDLINE MEDLINE NNP cord-010119-t1x9gknd 5353 17 and and CC cord-010119-t1x9gknd 5353 18 EMBASE EMBASE NNP cord-010119-t1x9gknd 5353 19 from from IN cord-010119-t1x9gknd 5353 20 inception inception NN cord-010119-t1x9gknd 5353 21 to to IN cord-010119-t1x9gknd 5353 22 July July NNP cord-010119-t1x9gknd 5353 23 2016 2016 CD cord-010119-t1x9gknd 5353 24 ; ; : cord-010119-t1x9gknd 5353 25 reference reference NN cord-010119-t1x9gknd 5353 26 lists list NNS cord-010119-t1x9gknd 5353 27 of of IN cord-010119-t1x9gknd 5353 28 published publish VBN cord-010119-t1x9gknd 5353 29 guidelines guideline NNS cord-010119-t1x9gknd 5353 30 , , , cord-010119-t1x9gknd 5353 31 reviews review NNS cord-010119-t1x9gknd 5353 32 and and CC cord-010119-t1x9gknd 5353 33 associated associated JJ cord-010119-t1x9gknd 5353 34 papers paper NNS cord-010119-t1x9gknd 5353 35 , , , cord-010119-t1x9gknd 5353 36 as as RB cord-010119-t1x9gknd 5353 37 well well RB cord-010119-t1x9gknd 5353 38 as as IN cord-010119-t1x9gknd 5353 39 conference conference NN cord-010119-t1x9gknd 5353 40 proceedings proceeding NNS cord-010119-t1x9gknd 5353 41 . . . cord-010119-t1x9gknd 5354 1 No no DT cord-010119-t1x9gknd 5354 2 language language NN cord-010119-t1x9gknd 5354 3 restrictions restriction NNS cord-010119-t1x9gknd 5354 4 were be VBD cord-010119-t1x9gknd 5354 5 applied apply VBN cord-010119-t1x9gknd 5354 6 . . . cord-010119-t1x9gknd 5355 1 We -PRON- PRP cord-010119-t1x9gknd 5355 2 included include VBD cord-010119-t1x9gknd 5355 3 randomized randomized JJ cord-010119-t1x9gknd 5355 4 controlled control VBN cord-010119-t1x9gknd 5355 5 trials trial NNS cord-010119-t1x9gknd 5355 6 in in IN cord-010119-t1x9gknd 5355 7 which which WDT cord-010119-t1x9gknd 5355 8 adult adult NN cord-010119-t1x9gknd 5355 9 patients patient NNS cord-010119-t1x9gknd 5355 10 undergoing undergo VBG cord-010119-t1x9gknd 5355 11 surgery surgery NN cord-010119-t1x9gknd 5355 12 received receive VBD cord-010119-t1x9gknd 5355 13 either either CC cord-010119-t1x9gknd 5355 14 an an DT cord-010119-t1x9gknd 5355 15 ESA ESA NNP cord-010119-t1x9gknd 5356 1 and/or and/or CC cord-010119-t1x9gknd 5356 2 iron iron NN cord-010119-t1x9gknd 5356 3 before before IN cord-010119-t1x9gknd 5356 4 surgery surgery NN cord-010119-t1x9gknd 5356 5 , , , cord-010119-t1x9gknd 5356 6 versus versus IN cord-010119-t1x9gknd 5356 7 iron iron NN cord-010119-t1x9gknd 5356 8 or or CC cord-010119-t1x9gknd 5356 9 no no DT cord-010119-t1x9gknd 5356 10 intervention intervention NN cord-010119-t1x9gknd 5356 11 . . . cord-010119-t1x9gknd 5357 1 Three three CD cord-010119-t1x9gknd 5357 2 authors author NNS cord-010119-t1x9gknd 5357 3 independently independently RB cord-010119-t1x9gknd 5357 4 reviewed review VBD cord-010119-t1x9gknd 5357 5 the the DT cord-010119-t1x9gknd 5357 6 studies study NNS cord-010119-t1x9gknd 5357 7 and and CC cord-010119-t1x9gknd 5357 8 extracted extract VBD cord-010119-t1x9gknd 5357 9 data datum NNS cord-010119-t1x9gknd 5357 10 from from IN cord-010119-t1x9gknd 5357 11 included include VBN cord-010119-t1x9gknd 5357 12 trials trial NNS cord-010119-t1x9gknd 5357 13 . . . cord-010119-t1x9gknd 5358 1 Risk risk NN cord-010119-t1x9gknd 5358 2 of of IN cord-010119-t1x9gknd 5358 3 bias bias NN cord-010119-t1x9gknd 5358 4 was be VBD cord-010119-t1x9gknd 5358 5 assessed assess VBN cord-010119-t1x9gknd 5358 6 for for IN cord-010119-t1x9gknd 5358 7 all all DT cord-010119-t1x9gknd 5358 8 included include VBN cord-010119-t1x9gknd 5358 9 studies study NNS cord-010119-t1x9gknd 5358 10 . . . cord-010119-t1x9gknd 5359 1 Where where WRB cord-010119-t1x9gknd 5359 2 applicable applicable JJ cord-010119-t1x9gknd 5359 3 , , , cord-010119-t1x9gknd 5359 4 we -PRON- PRP cord-010119-t1x9gknd 5359 5 pooled pool VBD cord-010119-t1x9gknd 5359 6 risk risk NN cord-010119-t1x9gknd 5359 7 ratios ratio NNS cord-010119-t1x9gknd 5359 8 of of IN cord-010119-t1x9gknd 5359 9 dichotomous dichotomous JJ cord-010119-t1x9gknd 5359 10 outcomes outcome NNS cord-010119-t1x9gknd 5359 11 and and CC cord-010119-t1x9gknd 5359 12 mean mean VB cord-010119-t1x9gknd 5359 13 differences difference NNS cord-010119-t1x9gknd 5359 14 of of IN cord-010119-t1x9gknd 5359 15 continuous continuous JJ cord-010119-t1x9gknd 5359 16 outcomes outcome NNS cord-010119-t1x9gknd 5359 17 across across IN cord-010119-t1x9gknd 5359 18 trials trial NNS cord-010119-t1x9gknd 5359 19 using use VBG cord-010119-t1x9gknd 5359 20 randomeffects randomeffect NNS cord-010119-t1x9gknd 5359 21 models model NNS cord-010119-t1x9gknd 5359 22 . . . cord-010119-t1x9gknd 5360 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5360 2 primary primary JJ cord-010119-t1x9gknd 5360 3 outcome outcome NN cord-010119-t1x9gknd 5360 4 was be VBD cord-010119-t1x9gknd 5360 5 the the DT cord-010119-t1x9gknd 5360 6 number number NN cord-010119-t1x9gknd 5360 7 of of IN cord-010119-t1x9gknd 5360 8 patients patient NNS cord-010119-t1x9gknd 5360 9 transfused transfuse VBN cord-010119-t1x9gknd 5360 10 with with IN cord-010119-t1x9gknd 5360 11 red red JJ cord-010119-t1x9gknd 5360 12 blood blood NN cord-010119-t1x9gknd 5360 13 cells cell NNS cord-010119-t1x9gknd 5360 14 . . . cord-010119-t1x9gknd 5361 1 Secondary secondary JJ cord-010119-t1x9gknd 5361 2 outcomes outcome NNS cord-010119-t1x9gknd 5361 3 included include VBD cord-010119-t1x9gknd 5361 4 risk risk NN cord-010119-t1x9gknd 5361 5 of of IN cord-010119-t1x9gknd 5361 6 mortality mortality NN cord-010119-t1x9gknd 5361 7 and and CC cord-010119-t1x9gknd 5361 8 other other JJ cord-010119-t1x9gknd 5361 9 thrombovascular thrombovascular NNP cord-010119-t1x9gknd 5361 10 events event NNS cord-010119-t1x9gknd 5361 11 ( ( -LRB- cord-010119-t1x9gknd 5361 12 stroke stroke NN cord-010119-t1x9gknd 5361 13 , , , cord-010119-t1x9gknd 5361 14 myocardial myocardial JJ cord-010119-t1x9gknd 5361 15 infarction infarction NN cord-010119-t1x9gknd 5361 16 , , , cord-010119-t1x9gknd 5361 17 deep deep JJ cord-010119-t1x9gknd 5361 18 vein vein NN cord-010119-t1x9gknd 5361 19 thrombosis thrombosis NN cord-010119-t1x9gknd 5361 20 , , , cord-010119-t1x9gknd 5361 21 and and CC cord-010119-t1x9gknd 5361 22 pulmonary pulmonary JJ cord-010119-t1x9gknd 5361 23 embolism embolism NN cord-010119-t1x9gknd 5361 24 ) ) -RRB- cord-010119-t1x9gknd 5361 25 . . . cord-010119-t1x9gknd 5362 1 Results/ Results/ . cord-010119-t1x9gknd 5363 1 Finding finding NN cord-010119-t1x9gknd 5363 2 : : : cord-010119-t1x9gknd 5364 1 A a DT cord-010119-t1x9gknd 5364 2 total total NN cord-010119-t1x9gknd 5364 3 of of IN cord-010119-t1x9gknd 5364 4 79 79 CD cord-010119-t1x9gknd 5364 5 randomized randomized JJ cord-010119-t1x9gknd 5364 6 controlled control VBN cord-010119-t1x9gknd 5364 7 trials trial NNS cord-010119-t1x9gknd 5364 8 ( ( -LRB- cord-010119-t1x9gknd 5364 9 8 8 CD cord-010119-t1x9gknd 5364 10 , , , cord-010119-t1x9gknd 5364 11 Conclusion conclusion NN cord-010119-t1x9gknd 5364 12 : : : cord-010119-t1x9gknd 5365 1 Amongst amongst IN cord-010119-t1x9gknd 5365 2 patients patient NNS cord-010119-t1x9gknd 5365 3 undergoing undergo VBG cord-010119-t1x9gknd 5365 4 surgery surgery NN cord-010119-t1x9gknd 5365 5 , , , cord-010119-t1x9gknd 5365 6 the the DT cord-010119-t1x9gknd 5365 7 administration administration NN cord-010119-t1x9gknd 5365 8 of of IN cord-010119-t1x9gknd 5365 9 an an DT cord-010119-t1x9gknd 5365 10 ESA ESA NNP cord-010119-t1x9gknd 5365 11 in in IN cord-010119-t1x9gknd 5365 12 addition addition NN cord-010119-t1x9gknd 5365 13 to to IN cord-010119-t1x9gknd 5365 14 oral oral JJ cord-010119-t1x9gknd 5365 15 or or CC cord-010119-t1x9gknd 5365 16 i.v i.v NNP cord-010119-t1x9gknd 5365 17 . . NNP cord-010119-t1x9gknd 5365 18 iron iron NNP cord-010119-t1x9gknd 5365 19 was be VBD cord-010119-t1x9gknd 5365 20 associated associate VBN cord-010119-t1x9gknd 5365 21 with with IN cord-010119-t1x9gknd 5365 22 a a DT cord-010119-t1x9gknd 5365 23 reduction reduction NN cord-010119-t1x9gknd 5365 24 in in IN cord-010119-t1x9gknd 5365 25 patients patient NNS cord-010119-t1x9gknd 5365 26 requiring require VBG cord-010119-t1x9gknd 5365 27 RBC RBC NNP cord-010119-t1x9gknd 5365 28 transfusion transfusion NN cord-010119-t1x9gknd 5365 29 . . . cord-010119-t1x9gknd 5366 1 Intravenous intravenous JJ cord-010119-t1x9gknd 5366 2 iron iron NN cord-010119-t1x9gknd 5366 3 was be VBD cord-010119-t1x9gknd 5366 4 less less RBR cord-010119-t1x9gknd 5366 5 effective effective JJ cord-010119-t1x9gknd 5366 6 at at IN cord-010119-t1x9gknd 5366 7 reducing reduce VBG cord-010119-t1x9gknd 5366 8 RBC RBC NNP cord-010119-t1x9gknd 5366 9 transfusion transfusion NN cord-010119-t1x9gknd 5366 10 . . . cord-010119-t1x9gknd 5367 1 Neither neither DT cord-010119-t1x9gknd 5367 2 treatment treatment NN cord-010119-t1x9gknd 5367 3 was be VBD cord-010119-t1x9gknd 5367 4 associated associate VBN cord-010119-t1x9gknd 5367 5 with with IN cord-010119-t1x9gknd 5367 6 any any DT cord-010119-t1x9gknd 5367 7 clear clear JJ cord-010119-t1x9gknd 5367 8 increase increase NN cord-010119-t1x9gknd 5367 9 in in IN cord-010119-t1x9gknd 5367 10 risk risk NN cord-010119-t1x9gknd 5367 11 of of IN cord-010119-t1x9gknd 5367 12 adverse adverse JJ cord-010119-t1x9gknd 5367 13 thrombotic thrombotic JJ cord-010119-t1x9gknd 5367 14 events event NNS cord-010119-t1x9gknd 5367 15 . . . cord-010119-t1x9gknd 5368 1 Additional additional JJ cord-010119-t1x9gknd 5368 2 large large JJ cord-010119-t1x9gknd 5368 3 prospective prospective JJ cord-010119-t1x9gknd 5368 4 randomized randomize VBN cord-010119-t1x9gknd 5368 5 controlled control VBN cord-010119-t1x9gknd 5368 6 trials trial NNS cord-010119-t1x9gknd 5368 7 are be VBP cord-010119-t1x9gknd 5368 8 required require VBN cord-010119-t1x9gknd 5368 9 to to TO cord-010119-t1x9gknd 5368 10 determine determine VB cord-010119-t1x9gknd 5368 11 the the DT cord-010119-t1x9gknd 5368 12 optimal optimal JJ cord-010119-t1x9gknd 5368 13 management management NN cord-010119-t1x9gknd 5368 14 strategy strategy NN cord-010119-t1x9gknd 5368 15 for for IN cord-010119-t1x9gknd 5368 16 patients patient NNS cord-010119-t1x9gknd 5368 17 undergoing undergo VBG cord-010119-t1x9gknd 5368 18 surgery surgery NN cord-010119-t1x9gknd 5368 19 with with IN cord-010119-t1x9gknd 5368 20 iron iron NN cord-010119-t1x9gknd 5368 21 restricted restrict VBN cord-010119-t1x9gknd 5368 22 anemia anemia NN cord-010119-t1x9gknd 5368 23 . . . cord-010119-t1x9gknd 5369 1 Evidence evidence NN cord-010119-t1x9gknd 5369 2 Based base VBN cord-010119-t1x9gknd 5370 1 Blood blood NN cord-010119-t1x9gknd 5370 2 Therapeutics Therapeutics NNP cord-010119-t1x9gknd 5370 3 Scott Scott NNP cord-010119-t1x9gknd 5370 4 Neeley Neeley NNP cord-010119-t1x9gknd 5370 5 * * NFP cord-010119-t1x9gknd 5371 1 1 1 CD cord-010119-t1x9gknd 5371 2 and and CC cord-010119-t1x9gknd 5371 3 Stephanie Stephanie NNP cord-010119-t1x9gknd 5371 4 Rogers Rogers NNP cord-010119-t1x9gknd 5371 5 2 2 CD cord-010119-t1x9gknd 5371 6 . . . cord-010119-t1x9gknd 5372 1 1 1 LS cord-010119-t1x9gknd 5372 2 Dignity Dignity NNP cord-010119-t1x9gknd 5372 3 Health Health NNP cord-010119-t1x9gknd 5372 4 St St NNP cord-010119-t1x9gknd 5372 5 Joseph Joseph NNP cord-010119-t1x9gknd 5372 6 's 's POS cord-010119-t1x9gknd 5372 7 Medical Medical NNP cord-010119-t1x9gknd 5372 8 Center Center NNP cord-010119-t1x9gknd 5372 9 , , , cord-010119-t1x9gknd 5372 10 2 2 CD cord-010119-t1x9gknd 5372 11 Dignity Dignity NNP cord-010119-t1x9gknd 5372 12 Health Health NNP cord-010119-t1x9gknd 5372 13 Background Background NNP cord-010119-t1x9gknd 5372 14 / / SYM cord-010119-t1x9gknd 5372 15 Case Case NNP cord-010119-t1x9gknd 5372 16 Studies Studies NNPS cord-010119-t1x9gknd 5372 17 : : : cord-010119-t1x9gknd 5372 18 Over over IN cord-010119-t1x9gknd 5372 19 12 12 CD cord-010119-t1x9gknd 5372 20 million million CD cord-010119-t1x9gknd 5372 21 units unit NNS cord-010119-t1x9gknd 5372 22 of of IN cord-010119-t1x9gknd 5372 23 packed packed JJ cord-010119-t1x9gknd 5372 24 red red JJ cord-010119-t1x9gknd 5372 25 blood blood NN cord-010119-t1x9gknd 5372 26 cells cell NNS cord-010119-t1x9gknd 5372 27 ( ( -LRB- cord-010119-t1x9gknd 5372 28 PRBC PRBC NNP cord-010119-t1x9gknd 5372 29 ) ) -RRB- cord-010119-t1x9gknd 5372 30 are be VBP cord-010119-t1x9gknd 5372 31 transfused transfuse VBN cord-010119-t1x9gknd 5372 32 annually annually RB cord-010119-t1x9gknd 5372 33 in in IN cord-010119-t1x9gknd 5372 34 the the DT cord-010119-t1x9gknd 5372 35 United United NNP cord-010119-t1x9gknd 5372 36 States States NNP cord-010119-t1x9gknd 5372 37 and and CC cord-010119-t1x9gknd 5372 38 there there EX cord-010119-t1x9gknd 5372 39 is be VBZ cord-010119-t1x9gknd 5372 40 no no DT cord-010119-t1x9gknd 5372 41 clinical clinical JJ cord-010119-t1x9gknd 5372 42 basis basis NN cord-010119-t1x9gknd 5372 43 for for IN cord-010119-t1x9gknd 5372 44 as as RB cord-010119-t1x9gknd 5372 45 many many JJ cord-010119-t1x9gknd 5372 46 as as IN cord-010119-t1x9gknd 5372 47 half half NN cord-010119-t1x9gknd 5372 48 of of IN cord-010119-t1x9gknd 5372 49 these these DT cord-010119-t1x9gknd 5372 50 transfusions transfusion NNS cord-010119-t1x9gknd 5372 51 . . . cord-010119-t1x9gknd 5373 1 No no DT cord-010119-t1x9gknd 5373 2 randomized randomized JJ cord-010119-t1x9gknd 5373 3 prospective prospective JJ cord-010119-t1x9gknd 5373 4 trial trial NN cord-010119-t1x9gknd 5373 5 has have VBZ cord-010119-t1x9gknd 5373 6 ever ever RB cord-010119-t1x9gknd 5373 7 demonstrated demonstrate VBN cord-010119-t1x9gknd 5373 8 a a DT cord-010119-t1x9gknd 5373 9 clinical clinical JJ cord-010119-t1x9gknd 5373 10 benefit benefit NN cord-010119-t1x9gknd 5373 11 for for IN cord-010119-t1x9gknd 5373 12 transfusion transfusion NN cord-010119-t1x9gknd 5373 13 in in IN cord-010119-t1x9gknd 5373 14 mild mild JJ cord-010119-t1x9gknd 5373 15 to to IN cord-010119-t1x9gknd 5373 16 moderately moderately RB cord-010119-t1x9gknd 5373 17 anemic anemic JJ cord-010119-t1x9gknd 5373 18 patients patient NNS cord-010119-t1x9gknd 5373 19 and and CC cord-010119-t1x9gknd 5373 20 yet yet RB cord-010119-t1x9gknd 5373 21 there there EX cord-010119-t1x9gknd 5373 22 is be VBZ cord-010119-t1x9gknd 5373 23 a a DT cord-010119-t1x9gknd 5373 24 large large JJ cord-010119-t1x9gknd 5373 25 body body NN cord-010119-t1x9gknd 5373 26 of of IN cord-010119-t1x9gknd 5373 27 evidence evidence NN cord-010119-t1x9gknd 5373 28 which which WDT cord-010119-t1x9gknd 5373 29 has have VBZ cord-010119-t1x9gknd 5373 30 shown show VBN cord-010119-t1x9gknd 5373 31 that that IN cord-010119-t1x9gknd 5373 32 due due IN cord-010119-t1x9gknd 5373 33 to to IN cord-010119-t1x9gknd 5373 34 a a DT cord-010119-t1x9gknd 5373 35 variety variety NN cord-010119-t1x9gknd 5373 36 of of IN cord-010119-t1x9gknd 5373 37 reasons reason NNS cord-010119-t1x9gknd 5373 38 including include VBG cord-010119-t1x9gknd 5373 39 an an DT cord-010119-t1x9gknd 5373 40 immunomodulatory immunomodulatory JJ cord-010119-t1x9gknd 5373 41 effect effect NN cord-010119-t1x9gknd 5373 42 and and CC cord-010119-t1x9gknd 5373 43 the the DT cord-010119-t1x9gknd 5373 44 storage storage NN cord-010119-t1x9gknd 5373 45 lesion lesion NN cord-010119-t1x9gknd 5373 46 , , , cord-010119-t1x9gknd 5373 47 blood blood NN cord-010119-t1x9gknd 5373 48 transfusions transfusion NNS cord-010119-t1x9gknd 5373 49 can can MD cord-010119-t1x9gknd 5373 50 cause cause VB cord-010119-t1x9gknd 5373 51 considerable considerable JJ cord-010119-t1x9gknd 5373 52 harm harm NN cord-010119-t1x9gknd 5373 53 , , , cord-010119-t1x9gknd 5373 54 including include VBG cord-010119-t1x9gknd 5373 55 higher high JJR cord-010119-t1x9gknd 5373 56 risk risk NN cord-010119-t1x9gknd 5373 57 of of IN cord-010119-t1x9gknd 5373 58 hospital hospital NN cord-010119-t1x9gknd 5373 59 acquired acquire VBN cord-010119-t1x9gknd 5373 60 bacterial bacterial JJ cord-010119-t1x9gknd 5373 61 infections infection NNS cord-010119-t1x9gknd 5373 62 , , , cord-010119-t1x9gknd 5373 63 transfusion transfusion NN cord-010119-t1x9gknd 5373 64 related relate VBD cord-010119-t1x9gknd 5373 65 acute acute JJ cord-010119-t1x9gknd 5373 66 lung lung NN cord-010119-t1x9gknd 5373 67 injury injury NN cord-010119-t1x9gknd 5373 68 / / SYM cord-010119-t1x9gknd 5373 69 acute acute JJ cord-010119-t1x9gknd 5373 70 pulmonary pulmonary JJ cord-010119-t1x9gknd 5373 71 edema edema NN cord-010119-t1x9gknd 5373 72 , , , cord-010119-t1x9gknd 5373 73 acute acute JJ cord-010119-t1x9gknd 5373 74 myocardial myocardial JJ cord-010119-t1x9gknd 5373 75 infarction infarction NN cord-010119-t1x9gknd 5373 76 , , , cord-010119-t1x9gknd 5373 77 higher high JJR cord-010119-t1x9gknd 5373 78 recurrence recurrence NN cord-010119-t1x9gknd 5373 79 of of IN cord-010119-t1x9gknd 5373 80 rebleeding rebleeding NN cord-010119-t1x9gknd 5373 81 and and CC cord-010119-t1x9gknd 5373 82 higher high JJR cord-010119-t1x9gknd 5373 83 cancer cancer NN cord-010119-t1x9gknd 5373 84 recurrence recurrence NN cord-010119-t1x9gknd 5373 85 . . . cord-010119-t1x9gknd 5374 1 Study Study NNP cord-010119-t1x9gknd 5374 2 Design Design NNP cord-010119-t1x9gknd 5374 3 / / SYM cord-010119-t1x9gknd 5374 4 Methods method NNS cord-010119-t1x9gknd 5374 5 : : : cord-010119-t1x9gknd 5374 6 A a DT cord-010119-t1x9gknd 5374 7 system system NN cord-010119-t1x9gknd 5374 8 wide wide JJ cord-010119-t1x9gknd 5374 9 goal goal NN cord-010119-t1x9gknd 5374 10 was be VBD cord-010119-t1x9gknd 5374 11 launched launch VBN cord-010119-t1x9gknd 5374 12 across across IN cord-010119-t1x9gknd 5374 13 39 39 CD cord-010119-t1x9gknd 5374 14 hospitals hospital NNS cord-010119-t1x9gknd 5374 15 to to TO cord-010119-t1x9gknd 5374 16 decrease decrease VB cord-010119-t1x9gknd 5374 17 the the DT cord-010119-t1x9gknd 5374 18 number number NN cord-010119-t1x9gknd 5374 19 of of IN cord-010119-t1x9gknd 5374 20 PRBC PRBC NNP cord-010119-t1x9gknd 5374 21 transfusions transfusion NNS cord-010119-t1x9gknd 5374 22 given give VBN cord-010119-t1x9gknd 5374 23 to to IN cord-010119-t1x9gknd 5374 24 clinically clinically RB cord-010119-t1x9gknd 5374 25 stable stable JJ cord-010119-t1x9gknd 5374 26 patients patient NNS cord-010119-t1x9gknd 5374 27 with with IN cord-010119-t1x9gknd 5374 28 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5374 29 ( ( -LRB- cord-010119-t1x9gknd 5374 30 Hgb Hgb NNP cord-010119-t1x9gknd 5374 31 ) ) -RRB- cord-010119-t1x9gknd 5374 32 levels level NNS cord-010119-t1x9gknd 5374 33 > > XX cord-010119-t1x9gknd 5375 1 5 5 CD cord-010119-t1x9gknd 5375 2 7.0 7.0 CD cord-010119-t1x9gknd 5376 1 g g NNP cord-010119-t1x9gknd 5376 2 / / SYM cord-010119-t1x9gknd 5376 3 dL. dL. NNP cord-010119-t1x9gknd 5377 1 The the DT cord-010119-t1x9gknd 5377 2 numerator numerator NN cord-010119-t1x9gknd 5377 3 consisted consist VBD cord-010119-t1x9gknd 5377 4 of of IN cord-010119-t1x9gknd 5377 5 all all DT cord-010119-t1x9gknd 5377 6 PRBC PRBC NNP cord-010119-t1x9gknd 5377 7 units unit NNS cord-010119-t1x9gknd 5377 8 transfused transfuse VBN cord-010119-t1x9gknd 5377 9 to to IN cord-010119-t1x9gknd 5377 10 patients patient NNS cord-010119-t1x9gknd 5377 11 with with IN cord-010119-t1x9gknd 5377 12 a a DT cord-010119-t1x9gknd 5377 13 Hgb Hgb NNP cord-010119-t1x9gknd 5377 14 of of IN cord-010119-t1x9gknd 5377 15 7.0 7.0 CD cord-010119-t1x9gknd 5377 16 g g NN cord-010119-t1x9gknd 5377 17 / / SYM cord-010119-t1x9gknd 5377 18 dL dl NN cord-010119-t1x9gknd 5377 19 or or CC cord-010119-t1x9gknd 5377 20 greater great JJR cord-010119-t1x9gknd 5377 21 prior prior RB cord-010119-t1x9gknd 5377 22 to to IN cord-010119-t1x9gknd 5377 23 transfusion transfusion NN cord-010119-t1x9gknd 5377 24 and and CC cord-010119-t1x9gknd 5377 25 the the DT cord-010119-t1x9gknd 5377 26 denominator denominator NN cord-010119-t1x9gknd 5377 27 consisted consist VBD cord-010119-t1x9gknd 5377 28 of of IN cord-010119-t1x9gknd 5377 29 all all DT cord-010119-t1x9gknd 5377 30 PRBC PRBC NNP cord-010119-t1x9gknd 5377 31 units unit NNS cord-010119-t1x9gknd 5377 32 transfused transfuse VBN cord-010119-t1x9gknd 5377 33 . . . cord-010119-t1x9gknd 5378 1 Exclusions exclusion NNS cord-010119-t1x9gknd 5378 2 included include VBD cord-010119-t1x9gknd 5378 3 cardiac cardiac JJ cord-010119-t1x9gknd 5378 4 surgery surgery NN cord-010119-t1x9gknd 5378 5 , , , cord-010119-t1x9gknd 5378 6 Nursery Nursery NNP cord-010119-t1x9gknd 5378 7 , , , cord-010119-t1x9gknd 5378 8 NICU NICU NNP cord-010119-t1x9gknd 5378 9 , , , cord-010119-t1x9gknd 5378 10 pregnancy pregnancy NN cord-010119-t1x9gknd 5378 11 , , , cord-010119-t1x9gknd 5378 12 post post JJ cord-010119-t1x9gknd 5378 13 - - JJ cord-010119-t1x9gknd 5378 14 partum partum JJ cord-010119-t1x9gknd 5378 15 hemorrhage hemorrhage NN cord-010119-t1x9gknd 5378 16 , , , cord-010119-t1x9gknd 5378 17 massive massive JJ cord-010119-t1x9gknd 5378 18 transfusion transfusion NN cord-010119-t1x9gknd 5378 19 protocol protocol NN cord-010119-t1x9gknd 5378 20 and and CC cord-010119-t1x9gknd 5378 21 transfusions transfusion NNS cord-010119-t1x9gknd 5378 22 in in IN cord-010119-t1x9gknd 5378 23 which which WDT cord-010119-t1x9gknd 5378 24 4 4 CD cord-010119-t1x9gknd 5378 25 or or CC cord-010119-t1x9gknd 5378 26 more more JJR cord-010119-t1x9gknd 5378 27 PRBC PRBC NNP cord-010119-t1x9gknd 5378 28 units unit NNS cord-010119-t1x9gknd 5378 29 were be VBD cord-010119-t1x9gknd 5378 30 transfused transfuse VBN cord-010119-t1x9gknd 5378 31 in in IN cord-010119-t1x9gknd 5378 32 one one CD cord-010119-t1x9gknd 5378 33 episode episode NN cord-010119-t1x9gknd 5378 34 . . . cord-010119-t1x9gknd 5379 1 Data datum NNS cord-010119-t1x9gknd 5379 2 was be VBD cord-010119-t1x9gknd 5379 3 extracted extract VBN cord-010119-t1x9gknd 5379 4 directly directly RB cord-010119-t1x9gknd 5379 5 from from IN cord-010119-t1x9gknd 5379 6 the the DT cord-010119-t1x9gknd 5379 7 Electronic Electronic NNP cord-010119-t1x9gknd 5379 8 Medical Medical NNP cord-010119-t1x9gknd 5379 9 Record Record NNP cord-010119-t1x9gknd 5379 10 and and CC cord-010119-t1x9gknd 5379 11 hospitals hospital NNS cord-010119-t1x9gknd 5379 12 received receive VBD cord-010119-t1x9gknd 5379 13 patient patient JJ cord-010119-t1x9gknd 5379 14 level level NN cord-010119-t1x9gknd 5379 15 detail detail NN cord-010119-t1x9gknd 5379 16 every every DT cord-010119-t1x9gknd 5379 17 month month NN cord-010119-t1x9gknd 5379 18 for for IN cord-010119-t1x9gknd 5379 19 all all DT cord-010119-t1x9gknd 5379 20 PRBC PRBC NNP cord-010119-t1x9gknd 5379 21 units unit NNS cord-010119-t1x9gknd 5379 22 transfused transfuse VBN cord-010119-t1x9gknd 5379 23 to to IN cord-010119-t1x9gknd 5379 24 patients patient NNS cord-010119-t1x9gknd 5379 25 with with IN cord-010119-t1x9gknd 5379 26 a a DT cord-010119-t1x9gknd 5379 27 Hgb Hgb NNP cord-010119-t1x9gknd 5379 28 of of IN cord-010119-t1x9gknd 5379 29 7.0 7.0 CD cord-010119-t1x9gknd 5379 30 g g NN cord-010119-t1x9gknd 5379 31 / / SYM cord-010119-t1x9gknd 5379 32 dL dl NN cord-010119-t1x9gknd 5379 33 or or CC cord-010119-t1x9gknd 5379 34 higher high JJR cord-010119-t1x9gknd 5379 35 prior prior RB cord-010119-t1x9gknd 5379 36 to to IN cord-010119-t1x9gknd 5379 37 transfusion transfusion NN cord-010119-t1x9gknd 5379 38 . . . cord-010119-t1x9gknd 5380 1 An an DT cord-010119-t1x9gknd 5380 2 extensive extensive JJ cord-010119-t1x9gknd 5380 3 educational educational JJ cord-010119-t1x9gknd 5380 4 campaign campaign NN cord-010119-t1x9gknd 5380 5 re re NN cord-010119-t1x9gknd 5380 6 : : : cord-010119-t1x9gknd 5380 7 evidence evidence NN cord-010119-t1x9gknd 5380 8 - - HYPH cord-010119-t1x9gknd 5380 9 based base VBN cord-010119-t1x9gknd 5380 10 transfusion transfusion NN cord-010119-t1x9gknd 5380 11 practice practice NN cord-010119-t1x9gknd 5380 12 was be VBD cord-010119-t1x9gknd 5380 13 launched launch VBN cord-010119-t1x9gknd 5380 14 for for IN cord-010119-t1x9gknd 5380 15 Physicians Physicians NNPS cord-010119-t1x9gknd 5380 16 and and CC cord-010119-t1x9gknd 5380 17 Nurses Nurses NNPS cord-010119-t1x9gknd 5380 18 , , , cord-010119-t1x9gknd 5380 19 including include VBG cord-010119-t1x9gknd 5380 20 the the DT cord-010119-t1x9gknd 5380 21 development development NN cord-010119-t1x9gknd 5380 22 of of IN cord-010119-t1x9gknd 5380 23 a a DT cord-010119-t1x9gknd 5380 24 Blood Blood NNP cord-010119-t1x9gknd 5380 25 Therapeutics Therapeutics NNP cord-010119-t1x9gknd 5380 26 toolkit toolkit NN cord-010119-t1x9gknd 5380 27 , , , cord-010119-t1x9gknd 5380 28 development development NN cord-010119-t1x9gknd 5380 29 of of IN cord-010119-t1x9gknd 5380 30 standardized standardized JJ cord-010119-t1x9gknd 5380 31 Dignity Dignity NNP cord-010119-t1x9gknd 5380 32 Health Health NNP cord-010119-t1x9gknd 5380 33 Blood Blood NNP cord-010119-t1x9gknd 5380 34 Therapeutics Therapeutics NNP cord-010119-t1x9gknd 5380 35 Guidelines Guidelines NNPS cord-010119-t1x9gknd 5380 36 , , , cord-010119-t1x9gknd 5380 37 a a DT cord-010119-t1x9gknd 5380 38 one one CD cord-010119-t1x9gknd 5380 39 day day NN cord-010119-t1x9gknd 5380 40 Blood blood NN cord-010119-t1x9gknd 5380 41 Therapeutics Therapeutics NNP cord-010119-t1x9gknd 5380 42 Advanced Advanced NNP cord-010119-t1x9gknd 5380 43 Training Training NNP cord-010119-t1x9gknd 5380 44 Symposium Symposium NNP cord-010119-t1x9gknd 5380 45 , , , cord-010119-t1x9gknd 5380 46 on on IN cord-010119-t1x9gknd 5380 47 - - HYPH cord-010119-t1x9gknd 5380 48 site site NN cord-010119-t1x9gknd 5380 49 visits visit NNS cord-010119-t1x9gknd 5380 50 to to IN cord-010119-t1x9gknd 5380 51 21 21 CD cord-010119-t1x9gknd 5380 52 hospitals hospital NNS cord-010119-t1x9gknd 5380 53 including include VBG cord-010119-t1x9gknd 5380 54 16 16 CD cord-010119-t1x9gknd 5380 55 CME CME NNP cord-010119-t1x9gknd 5380 56 presentations presentation NNS cord-010119-t1x9gknd 5380 57 , , , cord-010119-t1x9gknd 5380 58 online online JJ cord-010119-t1x9gknd 5380 59 Physician Physician NNP cord-010119-t1x9gknd 5380 60 and and CC cord-010119-t1x9gknd 5380 61 Nursing nursing NN cord-010119-t1x9gknd 5380 62 educational educational JJ cord-010119-t1x9gknd 5380 63 videos video NNS cord-010119-t1x9gknd 5380 64 , , , cord-010119-t1x9gknd 5380 65 communication communication NN cord-010119-t1x9gknd 5380 66 tools tool NNS cord-010119-t1x9gknd 5380 67 including include VBG cord-010119-t1x9gknd 5380 68 infographics infographic NNS cord-010119-t1x9gknd 5380 69 and and CC cord-010119-t1x9gknd 5380 70 " " `` cord-010119-t1x9gknd 5380 71 7 7 CD cord-010119-t1x9gknd 5380 72 is be VBZ cord-010119-t1x9gknd 5380 73 the the DT cord-010119-t1x9gknd 5380 74 new new JJ cord-010119-t1x9gknd 5380 75 10 10 CD cord-010119-t1x9gknd 5380 76 " " `` cord-010119-t1x9gknd 5380 77 buttons button NNS cord-010119-t1x9gknd 5380 78 , , , cord-010119-t1x9gknd 5380 79 development development NN cord-010119-t1x9gknd 5380 80 of of IN cord-010119-t1x9gknd 5380 81 a a DT cord-010119-t1x9gknd 5380 82 patient patient JJ cord-010119-t1x9gknd 5380 83 education education NN cord-010119-t1x9gknd 5380 84 resource resource NN cord-010119-t1x9gknd 5380 85 and and CC cord-010119-t1x9gknd 5380 86 bi bi JJ cord-010119-t1x9gknd 5380 87 - - JJ cord-010119-t1x9gknd 5380 88 monthly monthly JJ cord-010119-t1x9gknd 5380 89 webinars webinar NNS cord-010119-t1x9gknd 5380 90 with with IN cord-010119-t1x9gknd 5380 91 various various JJ cord-010119-t1x9gknd 5380 92 educational educational JJ cord-010119-t1x9gknd 5380 93 topics topic NNS cord-010119-t1x9gknd 5380 94 and and CC cord-010119-t1x9gknd 5380 95 speakers speaker NNS cord-010119-t1x9gknd 5380 96 . . . cord-010119-t1x9gknd 5381 1 Additionally additionally RB cord-010119-t1x9gknd 5381 2 , , , cord-010119-t1x9gknd 5381 3 the the DT cord-010119-t1x9gknd 5381 4 EHR EHR NNP cord-010119-t1x9gknd 5381 5 powerplans powerplan NNS cord-010119-t1x9gknd 5381 6 were be VBD cord-010119-t1x9gknd 5381 7 revised revise VBN cord-010119-t1x9gknd 5381 8 to to TO cord-010119-t1x9gknd 5381 9 ensure ensure VB cord-010119-t1x9gknd 5381 10 available available JJ cord-010119-t1x9gknd 5381 11 selections selection NNS cord-010119-t1x9gknd 5381 12 for for IN cord-010119-t1x9gknd 5381 13 " " `` cord-010119-t1x9gknd 5381 14 Transfusion Transfusion NNP cord-010119-t1x9gknd 5381 15 Indication Indication NNP cord-010119-t1x9gknd 5381 16 " " '' cord-010119-t1x9gknd 5381 17 ( ( -LRB- cord-010119-t1x9gknd 5381 18 required require VBN cord-010119-t1x9gknd 5381 19 field field NN cord-010119-t1x9gknd 5381 20 ) ) -RRB- cord-010119-t1x9gknd 5381 21 were be VBD cord-010119-t1x9gknd 5381 22 aligned align VBN cord-010119-t1x9gknd 5381 23 with with IN cord-010119-t1x9gknd 5381 24 evidence evidence NN cord-010119-t1x9gknd 5381 25 based base VBN cord-010119-t1x9gknd 5381 26 guidelines guideline NNS cord-010119-t1x9gknd 5381 27 . . . cord-010119-t1x9gknd 5382 1 Facilties faciltie NNS cord-010119-t1x9gknd 5382 2 were be VBD cord-010119-t1x9gknd 5382 3 encouraged encourage VBN cord-010119-t1x9gknd 5382 4 to to TO cord-010119-t1x9gknd 5382 5 develop develop VB cord-010119-t1x9gknd 5382 6 multi multi JJ cord-010119-t1x9gknd 5382 7 - - JJ cord-010119-t1x9gknd 5382 8 disciplinary disciplinary JJ cord-010119-t1x9gknd 5382 9 Blood Blood NNP cord-010119-t1x9gknd 5382 10 Therapeutics Therapeutics NNPS cord-010119-t1x9gknd 5382 11 Committees Committees NNPS cord-010119-t1x9gknd 5382 12 to to TO cord-010119-t1x9gknd 5382 13 review review VB cord-010119-t1x9gknd 5382 14 all all DT cord-010119-t1x9gknd 5382 15 transfusions transfusion NNS cord-010119-t1x9gknd 5382 16 given give VBN cord-010119-t1x9gknd 5382 17 to to IN cord-010119-t1x9gknd 5382 18 patients patient NNS cord-010119-t1x9gknd 5382 19 with with IN cord-010119-t1x9gknd 5382 20 pre pre JJ cord-010119-t1x9gknd 5382 21 - - JJ cord-010119-t1x9gknd 5382 22 transfusion transfusion NN cord-010119-t1x9gknd 5382 23 Hgb Hgb NNP cord-010119-t1x9gknd 5382 24 > > XX cord-010119-t1x9gknd 5383 1 5 5 CD cord-010119-t1x9gknd 5383 2 7.0 7.0 CD cord-010119-t1x9gknd 5383 3 g g NN cord-010119-t1x9gknd 5383 4 / / SYM cord-010119-t1x9gknd 5383 5 dL dl NN cord-010119-t1x9gknd 5383 6 on on IN cord-010119-t1x9gknd 5383 7 a a DT cord-010119-t1x9gknd 5383 8 routine routine JJ cord-010119-t1x9gknd 5383 9 basis basis NN cord-010119-t1x9gknd 5383 10 , , , cord-010119-t1x9gknd 5383 11 providing provide VBG cord-010119-t1x9gknd 5383 12 feedback feedback NN cord-010119-t1x9gknd 5383 13 to to IN cord-010119-t1x9gknd 5383 14 Providers provider NNS cord-010119-t1x9gknd 5383 15 whose whose WP$ cord-010119-t1x9gknd 5383 16 transfusions transfusion NNS cord-010119-t1x9gknd 5383 17 were be VBD cord-010119-t1x9gknd 5383 18 deemed deem VBN cord-010119-t1x9gknd 5383 19 not not RB cord-010119-t1x9gknd 5383 20 in in IN cord-010119-t1x9gknd 5383 21 accordance accordance NN cord-010119-t1x9gknd 5383 22 with with IN cord-010119-t1x9gknd 5383 23 current current JJ cord-010119-t1x9gknd 5383 24 evidence evidence NN cord-010119-t1x9gknd 5383 25 - - HYPH cord-010119-t1x9gknd 5383 26 based base VBN cord-010119-t1x9gknd 5383 27 guidelines guideline NNS cord-010119-t1x9gknd 5383 28 . . . cord-010119-t1x9gknd 5384 1 Results result NNS cord-010119-t1x9gknd 5384 2 / / SYM cord-010119-t1x9gknd 5384 3 Findings finding NNS cord-010119-t1x9gknd 5384 4 : : : cord-010119-t1x9gknd 5385 1 From from IN cord-010119-t1x9gknd 5385 2 FY2015 FY2015 NNP cord-010119-t1x9gknd 5385 3 to to IN cord-010119-t1x9gknd 5385 4 FYTD2017 fytd2017 CD cord-010119-t1x9gknd 5385 5 , , , cord-010119-t1x9gknd 5385 6 there there EX cord-010119-t1x9gknd 5385 7 was be VBD cord-010119-t1x9gknd 5385 8 a a DT cord-010119-t1x9gknd 5385 9 26 26 CD cord-010119-t1x9gknd 5385 10 % % NN cord-010119-t1x9gknd 5385 11 reduction reduction NN cord-010119-t1x9gknd 5385 12 in in IN cord-010119-t1x9gknd 5385 13 PRBC PRBC NNP cord-010119-t1x9gknd 5385 14 units unit NNS cord-010119-t1x9gknd 5385 15 transfused transfuse VBN cord-010119-t1x9gknd 5385 16 to to IN cord-010119-t1x9gknd 5385 17 patients patient NNS cord-010119-t1x9gknd 5385 18 with with IN cord-010119-t1x9gknd 5385 19 Hgb Hgb NNP cord-010119-t1x9gknd 5385 20 > > XX cord-010119-t1x9gknd 5386 1 5 5 CD cord-010119-t1x9gknd 5386 2 7.0 7.0 CD cord-010119-t1x9gknd 5386 3 g g NN cord-010119-t1x9gknd 5386 4 / / SYM cord-010119-t1x9gknd 5386 5 dL dl NN cord-010119-t1x9gknd 5386 6 , , , cord-010119-t1x9gknd 5386 7 starting start VBG cord-010119-t1x9gknd 5386 8 at at IN cord-010119-t1x9gknd 5386 9 a a DT cord-010119-t1x9gknd 5386 10 baseline baseline NN cord-010119-t1x9gknd 5386 11 of of IN cord-010119-t1x9gknd 5386 12 67 67 CD cord-010119-t1x9gknd 5386 13 % % NN cord-010119-t1x9gknd 5386 14 down down RB cord-010119-t1x9gknd 5386 15 to to IN cord-010119-t1x9gknd 5386 16 41 41 CD cord-010119-t1x9gknd 5386 17 % % NN cord-010119-t1x9gknd 5386 18 . . . cord-010119-t1x9gknd 5387 1 This this DT cord-010119-t1x9gknd 5387 2 represents represent VBZ cord-010119-t1x9gknd 5387 3 an an DT cord-010119-t1x9gknd 5387 4 FY17 FY17 NNP cord-010119-t1x9gknd 5387 5 annualized annualize VBN cord-010119-t1x9gknd 5387 6 savings saving NNS cord-010119-t1x9gknd 5387 7 of of IN cord-010119-t1x9gknd 5387 8 $ $ $ cord-010119-t1x9gknd 5387 9 9.732 9.732 CD cord-010119-t1x9gknd 5387 10 M M NNP cord-010119-t1x9gknd 5387 11 , , , cord-010119-t1x9gknd 5387 12 from from IN cord-010119-t1x9gknd 5387 13 a a DT cord-010119-t1x9gknd 5387 14 baseline baseline NN cord-010119-t1x9gknd 5387 15 of of IN cord-010119-t1x9gknd 5387 16 82 82 CD cord-010119-t1x9gknd 5387 17 units unit NNS cord-010119-t1x9gknd 5387 18 per per IN cord-010119-t1x9gknd 5387 19 1,000 1,000 CD cord-010119-t1x9gknd 5387 20 patients patient NNS cord-010119-t1x9gknd 5387 21 days day NNS cord-010119-t1x9gknd 5387 22 down down RB cord-010119-t1x9gknd 5387 23 to to IN cord-010119-t1x9gknd 5387 24 an an DT cord-010119-t1x9gknd 5387 25 average average JJ cord-010119-t1x9gknd 5387 26 71 71 CD cord-010119-t1x9gknd 5387 27 units unit NNS cord-010119-t1x9gknd 5387 28 and and CC cord-010119-t1x9gknd 5387 29 approximately approximately RB cord-010119-t1x9gknd 5387 30 2,000 2,000 CD cord-010119-t1x9gknd 5387 31 fewer few JJR cord-010119-t1x9gknd 5387 32 units unit NNS cord-010119-t1x9gknd 5387 33 transfused transfuse VBN cord-010119-t1x9gknd 5387 34 per per IN cord-010119-t1x9gknd 5387 35 month month NN cord-010119-t1x9gknd 5387 36 . . . cord-010119-t1x9gknd 5388 1 Conclusion conclusion NN cord-010119-t1x9gknd 5388 2 : : : cord-010119-t1x9gknd 5388 3 Blood blood NN cord-010119-t1x9gknd 5388 4 transfusions transfusion NNS cord-010119-t1x9gknd 5388 5 , , , cord-010119-t1x9gknd 5388 6 while while IN cord-010119-t1x9gknd 5388 7 life life NN cord-010119-t1x9gknd 5388 8 saving saving NN cord-010119-t1x9gknd 5388 9 , , , cord-010119-t1x9gknd 5388 10 should should MD cord-010119-t1x9gknd 5388 11 be be VB cord-010119-t1x9gknd 5388 12 regarded regard VBN cord-010119-t1x9gknd 5388 13 as as IN cord-010119-t1x9gknd 5388 14 an an DT cord-010119-t1x9gknd 5388 15 organ organ NN cord-010119-t1x9gknd 5388 16 transplant transplant NN cord-010119-t1x9gknd 5388 17 and and CC cord-010119-t1x9gknd 5388 18 as as RB cord-010119-t1x9gknd 5388 19 such such JJ cord-010119-t1x9gknd 5388 20 they -PRON- PRP cord-010119-t1x9gknd 5388 21 carry carry VBP cord-010119-t1x9gknd 5388 22 considerable considerable JJ cord-010119-t1x9gknd 5388 23 risk risk NN cord-010119-t1x9gknd 5388 24 . . . cord-010119-t1x9gknd 5389 1 Transfusions transfusion NNS cord-010119-t1x9gknd 5389 2 to to IN cord-010119-t1x9gknd 5389 3 stable stable JJ cord-010119-t1x9gknd 5389 4 , , , cord-010119-t1x9gknd 5389 5 non non JJ cord-010119-t1x9gknd 5389 6 - - JJ cord-010119-t1x9gknd 5389 7 bleeding bleeding JJ cord-010119-t1x9gknd 5389 8 patients patient NNS cord-010119-t1x9gknd 5389 9 with with IN cord-010119-t1x9gknd 5389 10 Hgb Hgb NNP cord-010119-t1x9gknd 5389 11 levels level NNS cord-010119-t1x9gknd 5389 12 > > XX cord-010119-t1x9gknd 5390 1 5 5 CD cord-010119-t1x9gknd 5390 2 7.0 7.0 CD cord-010119-t1x9gknd 5390 3 g g NN cord-010119-t1x9gknd 5390 4 / / SYM cord-010119-t1x9gknd 5390 5 dL dl NN cord-010119-t1x9gknd 5390 6 are be VBP cord-010119-t1x9gknd 5390 7 not not RB cord-010119-t1x9gknd 5390 8 in in IN cord-010119-t1x9gknd 5390 9 accordance accordance NN cord-010119-t1x9gknd 5390 10 with with IN cord-010119-t1x9gknd 5390 11 evidence evidence NN cord-010119-t1x9gknd 5390 12 - - HYPH cord-010119-t1x9gknd 5390 13 based base VBN cord-010119-t1x9gknd 5390 14 guidelines guideline NNS cord-010119-t1x9gknd 5390 15 and and CC cord-010119-t1x9gknd 5390 16 should should MD cord-010119-t1x9gknd 5390 17 be be VB cord-010119-t1x9gknd 5390 18 avoided avoid VBN cord-010119-t1x9gknd 5390 19 due due IN cord-010119-t1x9gknd 5390 20 to to IN cord-010119-t1x9gknd 5390 21 the the DT cord-010119-t1x9gknd 5390 22 associated associate VBN cord-010119-t1x9gknd 5390 23 potential potential JJ cord-010119-t1x9gknd 5390 24 harm harm NN cord-010119-t1x9gknd 5390 25 . . . cord-010119-t1x9gknd 5391 1 Furthermore furthermore RB cord-010119-t1x9gknd 5391 2 , , , cord-010119-t1x9gknd 5391 3 this this DT cord-010119-t1x9gknd 5391 4 potential potential JJ cord-010119-t1x9gknd 5391 5 harm harm NN cord-010119-t1x9gknd 5391 6 is be VBZ cord-010119-t1x9gknd 5391 7 dose dose RB cord-010119-t1x9gknd 5391 8 dependent dependent JJ cord-010119-t1x9gknd 5391 9 , , , cord-010119-t1x9gknd 5391 10 so so CC cord-010119-t1x9gknd 5391 11 if if IN cord-010119-t1x9gknd 5391 12 the the DT cord-010119-t1x9gknd 5391 13 decision decision NN cord-010119-t1x9gknd 5391 14 to to TO cord-010119-t1x9gknd 5391 15 transfuse transfuse VB cord-010119-t1x9gknd 5391 16 is be VBZ cord-010119-t1x9gknd 5391 17 made make VBN cord-010119-t1x9gknd 5391 18 , , , cord-010119-t1x9gknd 5391 19 one one CD cord-010119-t1x9gknd 5391 20 unit unit NN cord-010119-t1x9gknd 5391 21 of of IN cord-010119-t1x9gknd 5391 22 PRBC PRBC NNP cord-010119-t1x9gknd 5391 23 should should MD cord-010119-t1x9gknd 5391 24 be be VB cord-010119-t1x9gknd 5391 25 transfused transfuse VBN cord-010119-t1x9gknd 5391 26 rather rather RB cord-010119-t1x9gknd 5391 27 than than IN cord-010119-t1x9gknd 5391 28 two two CD cord-010119-t1x9gknd 5391 29 . . . cord-010119-t1x9gknd 5392 1 Three three CD cord-010119-t1x9gknd 5392 2 AF AF NNP cord-010119-t1x9gknd 5392 3 studies study NNS cord-010119-t1x9gknd 5392 4 ( ( -LRB- cord-010119-t1x9gknd 5392 5 SDM5 SDM5 NNP cord-010119-t1x9gknd 5392 6 - - HYPH cord-010119-t1x9gknd 5392 7 0.258 0.258 CD cord-010119-t1x9gknd 5392 8 ) ) -RRB- cord-010119-t1x9gknd 5392 9 reduced reduce VBD cord-010119-t1x9gknd 5392 10 RBC RBC NNP cord-010119-t1x9gknd 5392 11 units unit NNS cord-010119-t1x9gknd 5392 12 and and CC cord-010119-t1x9gknd 5392 13 two two CD cord-010119-t1x9gknd 5392 14 studies study NNS cord-010119-t1x9gknd 5392 15 decreased decrease VBD cord-010119-t1x9gknd 5392 16 the the DT cord-010119-t1x9gknd 5392 17 percentage percentage NN cord-010119-t1x9gknd 5392 18 of of IN cord-010119-t1x9gknd 5392 19 patients patient NNS cord-010119-t1x9gknd 5392 20 transfused transfuse VBN cord-010119-t1x9gknd 5392 21 ( ( -LRB- cord-010119-t1x9gknd 5392 22 OR5 OR5 NNP cord-010119-t1x9gknd 5392 23 0.700 0.700 CD cord-010119-t1x9gknd 5392 24 ) ) -RRB- cord-010119-t1x9gknd 5392 25 . . . cord-010119-t1x9gknd 5393 1 Forty forty CD cord-010119-t1x9gknd 5393 2 - - HYPH cord-010119-t1x9gknd 5393 3 three three CD cord-010119-t1x9gknd 5393 4 studies study NNS cord-010119-t1x9gknd 5393 5 showed show VBD cord-010119-t1x9gknd 5393 6 that that IN cord-010119-t1x9gknd 5393 7 intravenous intravenous JJ cord-010119-t1x9gknd 5393 8 tranexamic tranexamic JJ cord-010119-t1x9gknd 5393 9 acid acid NN cord-010119-t1x9gknd 5393 10 reduced reduce VBD cord-010119-t1x9gknd 5393 11 the the DT cord-010119-t1x9gknd 5393 12 percentage percentage NN cord-010119-t1x9gknd 5393 13 of of IN cord-010119-t1x9gknd 5393 14 patients patient NNS cord-010119-t1x9gknd 5393 15 ( ( -LRB- cord-010119-t1x9gknd 5393 16 OR OR NNP cord-010119-t1x9gknd 5393 17 50.264 50.264 CD cord-010119-t1x9gknd 5393 18 ) ) -RRB- cord-010119-t1x9gknd 5393 19 and and CC cord-010119-t1x9gknd 5393 20 RBC RBC NNP cord-010119-t1x9gknd 5393 21 units unit NNS cord-010119-t1x9gknd 5393 22 transfused transfuse VBD cord-010119-t1x9gknd 5393 23 ( ( -LRB- cord-010119-t1x9gknd 5393 24 SDM5 SDM5 NNP cord-010119-t1x9gknd 5393 25 - - HYPH cord-010119-t1x9gknd 5393 26 0.553 0.553 CD cord-010119-t1x9gknd 5393 27 ) ) -RRB- cord-010119-t1x9gknd 5393 28 . . . cord-010119-t1x9gknd 5394 1 Qualitative qualitative JJ cord-010119-t1x9gknd 5394 2 / / SYM cord-010119-t1x9gknd 5394 3 meta meta JJ cord-010119-t1x9gknd 5394 4 - - HYPH cord-010119-t1x9gknd 5394 5 analyses analysis NNS cord-010119-t1x9gknd 5394 6 were be VBD cord-010119-t1x9gknd 5394 7 translated translate VBN cord-010119-t1x9gknd 5394 8 into into IN cord-010119-t1x9gknd 5394 9 recommendations recommendation NNS cord-010119-t1x9gknd 5394 10 by by IN cord-010119-t1x9gknd 5394 11 an an DT cord-010119-t1x9gknd 5394 12 Expert Expert NNP cord-010119-t1x9gknd 5394 13 Panel Panel NNP cord-010119-t1x9gknd 5394 14 and and CC cord-010119-t1x9gknd 5394 15 approved approve VBN cord-010119-t1x9gknd 5394 16 by by IN cord-010119-t1x9gknd 5394 17 the the DT cord-010119-t1x9gknd 5394 18 LMBP LMBP NNP cord-010119-t1x9gknd 5394 19 Workgroup Workgroup NNP cord-010119-t1x9gknd 5394 20 for for IN cord-010119-t1x9gknd 5394 21 reducing reduce VBG cord-010119-t1x9gknd 5394 22 RBC RBC NNP cord-010119-t1x9gknd 5394 23 transfusion transfusion NN cord-010119-t1x9gknd 5394 24 . . . cord-010119-t1x9gknd 5395 1 Recommendations recommendation NNS cord-010119-t1x9gknd 5395 2 are be VBP cord-010119-t1x9gknd 5395 3 : : : cord-010119-t1x9gknd 5395 4 Early early JJ cord-010119-t1x9gknd 5395 5 assessment assessment NN cord-010119-t1x9gknd 5395 6 and and CC cord-010119-t1x9gknd 5395 7 effective effective JJ cord-010119-t1x9gknd 5395 8 AM am NN cord-010119-t1x9gknd 5395 9 ; ; : cord-010119-t1x9gknd 5395 10 RT RT NNP cord-010119-t1x9gknd 5395 11 , , , cord-010119-t1x9gknd 5395 12 Hb Hb NNP cord-010119-t1x9gknd 5395 13 alerts alert VBZ cord-010119-t1x9gknd 5395 14 in in IN cord-010119-t1x9gknd 5395 15 CPOE CPOE NNP cord-010119-t1x9gknd 5395 16 / / SYM cord-010119-t1x9gknd 5395 17 CDS cds NN cord-010119-t1x9gknd 5395 18 ; ; : cord-010119-t1x9gknd 5395 19 reduction reduction NN cord-010119-t1x9gknd 5395 20 of of IN cord-010119-t1x9gknd 5395 21 blood blood NN cord-010119-t1x9gknd 5395 22 loss loss NN cord-010119-t1x9gknd 5395 23 and and CC cord-010119-t1x9gknd 5395 24 AF af NN cord-010119-t1x9gknd 5395 25 assessing assess VBG cord-010119-t1x9gknd 5395 26 the the DT cord-010119-t1x9gknd 5395 27 percentage percentage NN cord-010119-t1x9gknd 5395 28 of of IN cord-010119-t1x9gknd 5395 29 patients patient NNS cord-010119-t1x9gknd 5395 30 and and CC cord-010119-t1x9gknd 5395 31 RBC RBC NNP cord-010119-t1x9gknd 5395 32 units unit NNS cord-010119-t1x9gknd 5395 33 transfused transfuse VBN cord-010119-t1x9gknd 5395 34 across across IN cord-010119-t1x9gknd 5395 35 cases case NNS cord-010119-t1x9gknd 5395 36 , , , cord-010119-t1x9gknd 5395 37 physicians physician NNS cord-010119-t1x9gknd 5395 38 and and CC cord-010119-t1x9gknd 5395 39 service service NN cord-010119-t1x9gknd 5395 40 areas area NNS cord-010119-t1x9gknd 5395 41 over over IN cord-010119-t1x9gknd 5395 42 discrete discrete JJ cord-010119-t1x9gknd 5395 43 periods period NNS cord-010119-t1x9gknd 5395 44 of of IN cord-010119-t1x9gknd 5395 45 time time NN cord-010119-t1x9gknd 5395 46 with with IN cord-010119-t1x9gknd 5395 47 feedback feedback NN cord-010119-t1x9gknd 5395 48 to to IN cord-010119-t1x9gknd 5395 49 physicians physician NNS cord-010119-t1x9gknd 5395 50 for for IN cord-010119-t1x9gknd 5395 51 continuous continuous JJ cord-010119-t1x9gknd 5395 52 quality quality NN cord-010119-t1x9gknd 5395 53 improvement improvement NN cord-010119-t1x9gknd 5395 54 . . . cord-010119-t1x9gknd 5396 1 Conclusion conclusion NN cord-010119-t1x9gknd 5396 2 : : : cord-010119-t1x9gknd 5397 1 Conclusion conclusion NN cord-010119-t1x9gknd 5397 2 : : : cord-010119-t1x9gknd 5398 1 The the DT cord-010119-t1x9gknd 5398 2 LMBP LMBP NNP cord-010119-t1x9gknd 5398 3 A-6 A-6 NNP cord-010119-t1x9gknd 5398 4 method method NN cord-010119-t1x9gknd 5398 5 led lead VBN cord-010119-t1x9gknd 5398 6 to to IN cord-010119-t1x9gknd 5398 7 evidence evidence NN cord-010119-t1x9gknd 5398 8 - - HYPH cord-010119-t1x9gknd 5398 9 based base VBN cord-010119-t1x9gknd 5398 10 recommendations recommendation NNS cord-010119-t1x9gknd 5398 11 for for IN cord-010119-t1x9gknd 5398 12 reducing reduce VBG cord-010119-t1x9gknd 5398 13 transfusion transfusion NN cord-010119-t1x9gknd 5398 14 . . . cord-010119-t1x9gknd 5399 1 Critical critical JJ cord-010119-t1x9gknd 5399 2 laboratory laboratory NN cord-010119-t1x9gknd 5399 3 support support NN cord-010119-t1x9gknd 5399 4 is be VBZ cord-010119-t1x9gknd 5399 5 needed need VBN cord-010119-t1x9gknd 5399 6 to to TO cord-010119-t1x9gknd 5399 7 achieve achieve VB cord-010119-t1x9gknd 5399 8 continuous continuous JJ cord-010119-t1x9gknd 5399 9 quality quality NN cord-010119-t1x9gknd 5399 10 and and CC cord-010119-t1x9gknd 5399 11 patient patient JJ cord-010119-t1x9gknd 5399 12 safety safety NN cord-010119-t1x9gknd 5399 13 . . . cord-010119-t1x9gknd 5399 14 _SP cord-010119-t1x9gknd 5400 1 Background Background NNP cord-010119-t1x9gknd 5400 2 / / SYM cord-010119-t1x9gknd 5400 3 Case Case NNP cord-010119-t1x9gknd 5400 4 Studies Studies NNPS cord-010119-t1x9gknd 5400 5 : : : cord-010119-t1x9gknd 5401 1 Reducing reduce VBG cord-010119-t1x9gknd 5401 2 the the DT cord-010119-t1x9gknd 5401 3 inappropriate inappropriate JJ cord-010119-t1x9gknd 5401 4 use use NN cord-010119-t1x9gknd 5401 5 of of IN cord-010119-t1x9gknd 5401 6 blood blood NN cord-010119-t1x9gknd 5401 7 products product NNS cord-010119-t1x9gknd 5401 8 via via IN cord-010119-t1x9gknd 5401 9 the the DT cord-010119-t1x9gknd 5401 10 implementation implementation NN cord-010119-t1x9gknd 5401 11 of of IN cord-010119-t1x9gknd 5401 12 evidence evidence NN cord-010119-t1x9gknd 5401 13 based base VBN cord-010119-t1x9gknd 5401 14 guidelines guideline NNS cord-010119-t1x9gknd 5401 15 is be VBZ cord-010119-t1x9gknd 5401 16 a a DT cord-010119-t1x9gknd 5401 17 main main JJ cord-010119-t1x9gknd 5401 18 tenet tenet NN cord-010119-t1x9gknd 5401 19 of of IN cord-010119-t1x9gknd 5401 20 patient patient JJ cord-010119-t1x9gknd 5401 21 blood blood NN cord-010119-t1x9gknd 5401 22 management management NN cord-010119-t1x9gknd 5401 23 . . . cord-010119-t1x9gknd 5402 1 The the DT cord-010119-t1x9gknd 5402 2 use use NN cord-010119-t1x9gknd 5402 3 of of IN cord-010119-t1x9gknd 5402 4 electronic electronic JJ cord-010119-t1x9gknd 5402 5 decision decision NN cord-010119-t1x9gknd 5402 6 support support NN cord-010119-t1x9gknd 5402 7 tools tool NNS cord-010119-t1x9gknd 5402 8 such such JJ cord-010119-t1x9gknd 5402 9 as as IN cord-010119-t1x9gknd 5402 10 best good JJS cord-010119-t1x9gknd 5402 11 practice practice NN cord-010119-t1x9gknd 5402 12 alerts alert NNS cord-010119-t1x9gknd 5402 13 ( ( -LRB- cord-010119-t1x9gknd 5402 14 BPAs bpas NN cord-010119-t1x9gknd 5402 15 ) ) -RRB- cord-010119-t1x9gknd 5402 16 to to TO cord-010119-t1x9gknd 5402 17 enforce enforce VB cord-010119-t1x9gknd 5402 18 red red JJ cord-010119-t1x9gknd 5402 19 blood blood NN cord-010119-t1x9gknd 5402 20 cell cell NN cord-010119-t1x9gknd 5402 21 ( ( -LRB- cord-010119-t1x9gknd 5402 22 RBC RBC NNP cord-010119-t1x9gknd 5402 23 ) ) -RRB- cord-010119-t1x9gknd 5402 24 transfusion transfusion NN cord-010119-t1x9gknd 5402 25 thresholds threshold NNS cord-010119-t1x9gknd 5402 26 have have VBP cord-010119-t1x9gknd 5402 27 been be VBN cord-010119-t1x9gknd 5402 28 shown show VBN cord-010119-t1x9gknd 5402 29 to to TO cord-010119-t1x9gknd 5402 30 reduce reduce VB cord-010119-t1x9gknd 5402 31 use use NN cord-010119-t1x9gknd 5402 32 by by IN cord-010119-t1x9gknd 5402 33 informing inform VBG cord-010119-t1x9gknd 5402 34 ordering order VBG cord-010119-t1x9gknd 5402 35 providers provider NNS cord-010119-t1x9gknd 5402 36 when when WRB cord-010119-t1x9gknd 5402 37 or or CC cord-010119-t1x9gknd 5402 38 when when WRB cord-010119-t1x9gknd 5402 39 not not RB cord-010119-t1x9gknd 5402 40 to to TO cord-010119-t1x9gknd 5402 41 transfuse transfuse VB cord-010119-t1x9gknd 5402 42 . . . cord-010119-t1x9gknd 5403 1 The the DT cord-010119-t1x9gknd 5403 2 tools tool NNS cord-010119-t1x9gknd 5403 3 in in IN cord-010119-t1x9gknd 5403 4 use use NN cord-010119-t1x9gknd 5403 5 to to IN cord-010119-t1x9gknd 5403 6 date date NN cord-010119-t1x9gknd 5403 7 have have VBP cord-010119-t1x9gknd 5403 8 not not RB cord-010119-t1x9gknd 5403 9 provided provide VBN cord-010119-t1x9gknd 5403 10 a a DT cord-010119-t1x9gknd 5403 11 dose dose NN cord-010119-t1x9gknd 5403 12 of of IN cord-010119-t1x9gknd 5403 13 RBCs rbc NNS cord-010119-t1x9gknd 5403 14 to to TO cord-010119-t1x9gknd 5403 15 transfuse transfuse VB cord-010119-t1x9gknd 5403 16 , , , cord-010119-t1x9gknd 5403 17 so so RB cord-010119-t1x9gknd 5403 18 in in IN cord-010119-t1x9gknd 5403 19 fact fact NN cord-010119-t1x9gknd 5403 20 providers provider NNS cord-010119-t1x9gknd 5403 21 can can MD cord-010119-t1x9gknd 5403 22 continue continue VB cord-010119-t1x9gknd 5403 23 to to IN cord-010119-t1x9gknd 5403 24 over over IN cord-010119-t1x9gknd 5403 25 - - HYPH cord-010119-t1x9gknd 5403 26 transfusion transfusion NN cord-010119-t1x9gknd 5403 27 based base VBN cord-010119-t1x9gknd 5403 28 on on IN cord-010119-t1x9gknd 5403 29 the the DT cord-010119-t1x9gknd 5403 30 number number NN cord-010119-t1x9gknd 5403 31 of of IN cord-010119-t1x9gknd 5403 32 units unit NNS cord-010119-t1x9gknd 5403 33 of of IN cord-010119-t1x9gknd 5403 34 RBC RBC NNP cord-010119-t1x9gknd 5403 35 given give VBN cord-010119-t1x9gknd 5403 36 . . . cord-010119-t1x9gknd 5404 1 A a DT cord-010119-t1x9gknd 5404 2 therapeutic therapeutic JJ cord-010119-t1x9gknd 5404 3 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5404 4 / / SYM cord-010119-t1x9gknd 5404 5 hematocrit hematocrit NN cord-010119-t1x9gknd 5404 6 ( ( -LRB- cord-010119-t1x9gknd 5404 7 Hgb Hgb NNP cord-010119-t1x9gknd 5404 8 / / SYM cord-010119-t1x9gknd 5404 9 HCT HCT NNP cord-010119-t1x9gknd 5404 10 ) ) -RRB- cord-010119-t1x9gknd 5404 11 targeted target VBN cord-010119-t1x9gknd 5404 12 approach approach NN cord-010119-t1x9gknd 5404 13 to to IN cord-010119-t1x9gknd 5404 14 RBC RBC NNP cord-010119-t1x9gknd 5404 15 indications/ indications/ NNP cord-010119-t1x9gknd 5404 16 orders order NNS cord-010119-t1x9gknd 5404 17 allows allow VBZ cord-010119-t1x9gknd 5404 18 for for IN cord-010119-t1x9gknd 5404 19 the the DT cord-010119-t1x9gknd 5404 20 calculation calculation NN cord-010119-t1x9gknd 5404 21 of of IN cord-010119-t1x9gknd 5404 22 a a DT cord-010119-t1x9gknd 5404 23 dose dose NN cord-010119-t1x9gknd 5404 24 of of IN cord-010119-t1x9gknd 5404 25 RBCs rbc NNS cord-010119-t1x9gknd 5404 26 to to TO cord-010119-t1x9gknd 5404 27 achieve achieve VB cord-010119-t1x9gknd 5404 28 the the DT cord-010119-t1x9gknd 5404 29 desired desire VBN cord-010119-t1x9gknd 5404 30 target target NN cord-010119-t1x9gknd 5404 31 and and CC cord-010119-t1x9gknd 5404 32 could could MD cord-010119-t1x9gknd 5404 33 further far RBR cord-010119-t1x9gknd 5404 34 reduce reduce VB cord-010119-t1x9gknd 5404 35 the the DT cord-010119-t1x9gknd 5404 36 use use NN cord-010119-t1x9gknd 5404 37 of of IN cord-010119-t1x9gknd 5404 38 RBC RBC NNP cord-010119-t1x9gknd 5404 39 units unit NNS cord-010119-t1x9gknd 5404 40 . . . cord-010119-t1x9gknd 5405 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5405 2 group group NN cord-010119-t1x9gknd 5405 3 has have VBZ cord-010119-t1x9gknd 5405 4 developed develop VBN cord-010119-t1x9gknd 5405 5 a a DT cord-010119-t1x9gknd 5405 6 computer computer NN cord-010119-t1x9gknd 5405 7 algorithm algorithm NN cord-010119-t1x9gknd 5405 8 to to TO cord-010119-t1x9gknd 5405 9 calculate calculate VB cord-010119-t1x9gknd 5405 10 RBC RBC NNP cord-010119-t1x9gknd 5405 11 dose dose NN cord-010119-t1x9gknd 5405 12 based base VBN cord-010119-t1x9gknd 5405 13 on on IN cord-010119-t1x9gknd 5405 14 patient patient JJ cord-010119-t1x9gknd 5405 15 specific specific JJ cord-010119-t1x9gknd 5405 16 data datum NNS cord-010119-t1x9gknd 5405 17 drawn draw VBN cord-010119-t1x9gknd 5405 18 from from IN cord-010119-t1x9gknd 5405 19 the the DT cord-010119-t1x9gknd 5405 20 electronic electronic JJ cord-010119-t1x9gknd 5405 21 medical medical JJ cord-010119-t1x9gknd 5405 22 record record NN cord-010119-t1x9gknd 5405 23 ( ( -LRB- cord-010119-t1x9gknd 5405 24 EMR EMR NNP cord-010119-t1x9gknd 5405 25 ) ) -RRB- cord-010119-t1x9gknd 5405 26 that that WDT cord-010119-t1x9gknd 5405 27 has have VBZ cord-010119-t1x9gknd 5405 28 been be VBN cord-010119-t1x9gknd 5405 29 used use VBN cord-010119-t1x9gknd 5405 30 in in IN cord-010119-t1x9gknd 5405 31 select select JJ cord-010119-t1x9gknd 5405 32 patient patient JJ cord-010119-t1x9gknd 5405 33 populations population NNS cord-010119-t1x9gknd 5405 34 but but CC cord-010119-t1x9gknd 5405 35 has have VBZ cord-010119-t1x9gknd 5405 36 not not RB cord-010119-t1x9gknd 5405 37 been be VBN cord-010119-t1x9gknd 5405 38 prospectively prospectively RB cord-010119-t1x9gknd 5405 39 applied apply VBN cord-010119-t1x9gknd 5405 40 to to IN cord-010119-t1x9gknd 5405 41 hospital hospital NN cord-010119-t1x9gknd 5405 42 wide wide JJ cord-010119-t1x9gknd 5405 43 clinical clinical JJ cord-010119-t1x9gknd 5405 44 practice practice NN cord-010119-t1x9gknd 5405 45 . . . cord-010119-t1x9gknd 5406 1 This this DT cord-010119-t1x9gknd 5406 2 study study NN cord-010119-t1x9gknd 5406 3 describes describe VBZ cord-010119-t1x9gknd 5406 4 our -PRON- PRP$ cord-010119-t1x9gknd 5406 5 initial initial JJ cord-010119-t1x9gknd 5406 6 experience experience NN cord-010119-t1x9gknd 5406 7 with with IN cord-010119-t1x9gknd 5406 8 the the DT cord-010119-t1x9gknd 5406 9 use use NN cord-010119-t1x9gknd 5406 10 of of IN cord-010119-t1x9gknd 5406 11 this this DT cord-010119-t1x9gknd 5406 12 algorithm algorithm NN cord-010119-t1x9gknd 5406 13 in in IN cord-010119-t1x9gknd 5406 14 non non JJ cord-010119-t1x9gknd 5406 15 - - JJ cord-010119-t1x9gknd 5406 16 surgical surgical JJ cord-010119-t1x9gknd 5406 17 RBC RBC NNP cord-010119-t1x9gknd 5406 18 transfusion transfusion NN cord-010119-t1x9gknd 5406 19 . . . cord-010119-t1x9gknd 5407 1 Study Study NNP cord-010119-t1x9gknd 5407 2 Design Design NNP cord-010119-t1x9gknd 5407 3 / / SYM cord-010119-t1x9gknd 5407 4 Method method NN cord-010119-t1x9gknd 5407 5 : : : cord-010119-t1x9gknd 5408 1 The the DT cord-010119-t1x9gknd 5408 2 Blood Blood NNP cord-010119-t1x9gknd 5408 3 Utilization utilization NN cord-010119-t1x9gknd 5408 4 Calculator calculator NN cord-010119-t1x9gknd 5408 5 ( ( -LRB- cord-010119-t1x9gknd 5408 6 BUC BUC NNP cord-010119-t1x9gknd 5408 7 ) ) -RRB- cord-010119-t1x9gknd 5408 8 is be VBZ cord-010119-t1x9gknd 5408 9 a a DT cord-010119-t1x9gknd 5408 10 mathematical mathematical JJ cord-010119-t1x9gknd 5408 11 formula formula NN cord-010119-t1x9gknd 5408 12 that that WDT cord-010119-t1x9gknd 5408 13 draws draw VBZ cord-010119-t1x9gknd 5408 14 patient patient JJ cord-010119-t1x9gknd 5408 15 specific specific JJ cord-010119-t1x9gknd 5408 16 information information NN cord-010119-t1x9gknd 5408 17 including include VBG cord-010119-t1x9gknd 5408 18 index index NN cord-010119-t1x9gknd 5408 19 Hgb/ Hgb/ NNP cord-010119-t1x9gknd 5408 20 HCT HCT NNP cord-010119-t1x9gknd 5408 21 and and CC cord-010119-t1x9gknd 5408 22 calculates calculate VBZ cord-010119-t1x9gknd 5408 23 a a DT cord-010119-t1x9gknd 5408 24 dose dose NN cord-010119-t1x9gknd 5408 25 in in IN cord-010119-t1x9gknd 5408 26 number number NN cord-010119-t1x9gknd 5408 27 of of IN cord-010119-t1x9gknd 5408 28 units unit NNS cord-010119-t1x9gknd 5408 29 of of IN cord-010119-t1x9gknd 5408 30 RBCs rbc NNS cord-010119-t1x9gknd 5408 31 to to TO cord-010119-t1x9gknd 5408 32 transfuse transfuse VB cord-010119-t1x9gknd 5408 33 in in IN cord-010119-t1x9gknd 5408 34 order order NN cord-010119-t1x9gknd 5408 35 to to TO cord-010119-t1x9gknd 5408 36 achieve achieve VB cord-010119-t1x9gknd 5408 37 a a DT cord-010119-t1x9gknd 5408 38 selected select VBN cord-010119-t1x9gknd 5408 39 target target NN cord-010119-t1x9gknd 5408 40 Hgb Hgb NNP cord-010119-t1x9gknd 5408 41 / / SYM cord-010119-t1x9gknd 5408 42 HCT HCT NNP cord-010119-t1x9gknd 5408 43 . . . cord-010119-t1x9gknd 5409 1 Hgb Hgb NNP cord-010119-t1x9gknd 5409 2 / / SYM cord-010119-t1x9gknd 5409 3 HCT HCT NNP cord-010119-t1x9gknd 5409 4 target target NN cord-010119-t1x9gknd 5409 5 based base VBN cord-010119-t1x9gknd 5409 6 indications indication NNS cord-010119-t1x9gknd 5409 7 for for IN cord-010119-t1x9gknd 5409 8 RBC RBC NNP cord-010119-t1x9gknd 5409 9 transfusion transfusion NN cord-010119-t1x9gknd 5409 10 were be VBD cord-010119-t1x9gknd 5409 11 designed design VBN cord-010119-t1x9gknd 5409 12 and and CC cord-010119-t1x9gknd 5409 13 used use VBN cord-010119-t1x9gknd 5409 14 as as IN cord-010119-t1x9gknd 5409 15 the the DT cord-010119-t1x9gknd 5409 16 basis basis NN cord-010119-t1x9gknd 5409 17 for for IN cord-010119-t1x9gknd 5409 18 RBC RBC NNP cord-010119-t1x9gknd 5409 19 order order NN cord-010119-t1x9gknd 5409 20 set set VBN cord-010119-t1x9gknd 5409 21 with with IN cord-010119-t1x9gknd 5409 22 in in IN cord-010119-t1x9gknd 5409 23 the the DT cord-010119-t1x9gknd 5409 24 EThe EThe NNP cord-010119-t1x9gknd 5409 25 BUC BUC NNP cord-010119-t1x9gknd 5409 26 was be VBD cord-010119-t1x9gknd 5409 27 embedded embed VBN cord-010119-t1x9gknd 5409 28 within within IN cord-010119-t1x9gknd 5409 29 the the DT cord-010119-t1x9gknd 5409 30 EMRs emr NNS cord-010119-t1x9gknd 5409 31 RBC RBC NNP cord-010119-t1x9gknd 5409 32 order order NN cord-010119-t1x9gknd 5409 33 set set VBN cord-010119-t1x9gknd 5409 34 to to TO cord-010119-t1x9gknd 5409 35 provide provide VB cord-010119-t1x9gknd 5409 36 a a DT cord-010119-t1x9gknd 5409 37 recommended recommend VBN cord-010119-t1x9gknd 5409 38 transfusion transfusion NN cord-010119-t1x9gknd 5409 39 dose dose NN cord-010119-t1x9gknd 5409 40 in in IN cord-010119-t1x9gknd 5409 41 number number NN cord-010119-t1x9gknd 5409 42 of of IN cord-010119-t1x9gknd 5409 43 units unit NNS cord-010119-t1x9gknd 5409 44 when when WRB cord-010119-t1x9gknd 5409 45 any any DT cord-010119-t1x9gknd 5409 46 nonsurgical nonsurgical JJ cord-010119-t1x9gknd 5409 47 RBC RBC NNP cord-010119-t1x9gknd 5409 48 indication indication NN cord-010119-t1x9gknd 5409 49 was be VBD cord-010119-t1x9gknd 5409 50 selected select VBN cord-010119-t1x9gknd 5409 51 . . . cord-010119-t1x9gknd 5410 1 The the DT cord-010119-t1x9gknd 5410 2 target target NN cord-010119-t1x9gknd 5410 3 Hgb Hgb NNP cord-010119-t1x9gknd 5410 4 / / SYM cord-010119-t1x9gknd 5410 5 HCT hct NN cord-010119-t1x9gknd 5410 6 for for IN cord-010119-t1x9gknd 5410 7 these these DT cord-010119-t1x9gknd 5410 8 indications indication NNS cord-010119-t1x9gknd 5410 9 was be VBD cord-010119-t1x9gknd 5410 10 7g 7g NNS cord-010119-t1x9gknd 5410 11 / / SYM cord-010119-t1x9gknd 5410 12 dL/21 dL/21 NNS cord-010119-t1x9gknd 5410 13 % % NN cord-010119-t1x9gknd 5410 14 or or CC cord-010119-t1x9gknd 5410 15 8g 8g CD cord-010119-t1x9gknd 5410 16 / / SYM cord-010119-t1x9gknd 5410 17 dL/24 dL/24 NNP cord-010119-t1x9gknd 5410 18 % % NN cord-010119-t1x9gknd 5410 19 . . . cord-010119-t1x9gknd 5411 1 The the DT cord-010119-t1x9gknd 5411 2 number number NN cord-010119-t1x9gknd 5411 3 of of IN cord-010119-t1x9gknd 5411 4 RBC RBC NNP cord-010119-t1x9gknd 5411 5 units unit NNS cord-010119-t1x9gknd 5411 6 ordered order VBN cord-010119-t1x9gknd 5411 7 and and CC cord-010119-t1x9gknd 5411 8 transfused transfuse VBN cord-010119-t1x9gknd 5411 9 were be VBD cord-010119-t1x9gknd 5411 10 tracked track VBN cord-010119-t1x9gknd 5411 11 prospectively prospectively RB cord-010119-t1x9gknd 5411 12 for for IN cord-010119-t1x9gknd 5411 13 each each DT cord-010119-t1x9gknd 5411 14 of of IN cord-010119-t1x9gknd 5411 15 the the DT cord-010119-t1x9gknd 5411 16 orderable orderable JJ cord-010119-t1x9gknd 5411 17 indications indication NNS cord-010119-t1x9gknd 5411 18 . . . cord-010119-t1x9gknd 5412 1 Comparison comparison NN cord-010119-t1x9gknd 5412 2 of of IN cord-010119-t1x9gknd 5412 3 units unit NNS cord-010119-t1x9gknd 5412 4 transfused transfuse VBN cord-010119-t1x9gknd 5412 5 per per IN cord-010119-t1x9gknd 5412 6 month month NN cord-010119-t1x9gknd 5412 7 before before RB cord-010119-t1x9gknd 5412 8 and and CC cord-010119-t1x9gknd 5412 9 after after IN cord-010119-t1x9gknd 5412 10 the the DT cord-010119-t1x9gknd 5412 11 BUC BUC NNP cord-010119-t1x9gknd 5412 12 implementation implementation NN cord-010119-t1x9gknd 5412 13 was be VBD cord-010119-t1x9gknd 5412 14 performed perform VBN cord-010119-t1x9gknd 5412 15 using use VBG cord-010119-t1x9gknd 5412 16 Student Student NNP cord-010119-t1x9gknd 5412 17 's 's POS cord-010119-t1x9gknd 5412 18 t t NN cord-010119-t1x9gknd 5412 19 - - HYPH cord-010119-t1x9gknd 5412 20 test test NN cord-010119-t1x9gknd 5412 21 . . . cord-010119-t1x9gknd 5413 1 Results result NNS cord-010119-t1x9gknd 5413 2 / / SYM cord-010119-t1x9gknd 5413 3 Finding finding NN cord-010119-t1x9gknd 5413 4 : : : cord-010119-t1x9gknd 5414 1 Historically historically RB cord-010119-t1x9gknd 5414 2 , , , cord-010119-t1x9gknd 5414 3 the the DT cord-010119-t1x9gknd 5414 4 three three CD cord-010119-t1x9gknd 5414 5 non non JJ cord-010119-t1x9gknd 5414 6 - - JJ cord-010119-t1x9gknd 5414 7 surgical surgical JJ cord-010119-t1x9gknd 5414 8 RBC RBC NNP cord-010119-t1x9gknd 5414 9 indications indication NNS cord-010119-t1x9gknd 5414 10 represented represent VBD cord-010119-t1x9gknd 5414 11 approximately approximately RB cord-010119-t1x9gknd 5414 12 42 42 CD cord-010119-t1x9gknd 5414 13 % % NN cord-010119-t1x9gknd 5414 14 of of IN cord-010119-t1x9gknd 5414 15 the the DT cord-010119-t1x9gknd 5414 16 total total JJ cord-010119-t1x9gknd 5414 17 RBC RBC NNP cord-010119-t1x9gknd 5414 18 transfused transfuse VBN cord-010119-t1x9gknd 5414 19 . . . cord-010119-t1x9gknd 5415 1 Prior prior RB cord-010119-t1x9gknd 5415 2 to to IN cord-010119-t1x9gknd 5415 3 the the DT cord-010119-t1x9gknd 5415 4 BUC BUC NNP cord-010119-t1x9gknd 5415 5 the the DT cord-010119-t1x9gknd 5415 6 mean mean JJ cord-010119-t1x9gknd 5415 7 number number NN cord-010119-t1x9gknd 5415 8 of of IN cord-010119-t1x9gknd 5415 9 non non JJ cord-010119-t1x9gknd 5415 10 - - JJ cord-010119-t1x9gknd 5415 11 surgical surgical JJ cord-010119-t1x9gknd 5415 12 RBC RBC NNP cord-010119-t1x9gknd 5415 13 units unit NNS cord-010119-t1x9gknd 5415 14 transfused transfuse VBN cord-010119-t1x9gknd 5415 15 was be VBD cord-010119-t1x9gknd 5415 16 590 590 CD cord-010119-t1x9gknd 5415 17 1 1 CD cord-010119-t1x9gknd 5415 18 24 24 CD cord-010119-t1x9gknd 5415 19 units/ units/ CD cord-010119-t1x9gknd 5415 20 month month NN cord-010119-t1x9gknd 5415 21 . . . cord-010119-t1x9gknd 5416 1 After after IN cord-010119-t1x9gknd 5416 2 the the DT cord-010119-t1x9gknd 5416 3 first first JJ cord-010119-t1x9gknd 5416 4 5 5 CD cord-010119-t1x9gknd 5416 5 months month NNS cord-010119-t1x9gknd 5416 6 of of IN cord-010119-t1x9gknd 5416 7 BUC BUC NNP cord-010119-t1x9gknd 5416 8 activation activation NN cord-010119-t1x9gknd 5416 9 the the DT cord-010119-t1x9gknd 5416 10 mean mean JJ cord-010119-t1x9gknd 5416 11 number number NN cord-010119-t1x9gknd 5416 12 of of IN cord-010119-t1x9gknd 5416 13 units unit NNS cord-010119-t1x9gknd 5416 14 was be VBD cord-010119-t1x9gknd 5416 15 439 439 CD cord-010119-t1x9gknd 5416 16 1 1 CD cord-010119-t1x9gknd 5416 17 50 50 CD cord-010119-t1x9gknd 5416 18 units unit NNS cord-010119-t1x9gknd 5416 19 / / SYM cord-010119-t1x9gknd 5416 20 month month NN cord-010119-t1x9gknd 5416 21 a a DT cord-010119-t1x9gknd 5416 22 reduction reduction NN cord-010119-t1x9gknd 5416 23 of of IN cord-010119-t1x9gknd 5416 24 151 151 CD cord-010119-t1x9gknd 5416 25 units unit NNS cord-010119-t1x9gknd 5416 26 / / SYM cord-010119-t1x9gknd 5416 27 month month NN cord-010119-t1x9gknd 5416 28 or or CC cord-010119-t1x9gknd 5416 29 26 26 CD cord-010119-t1x9gknd 5416 30 % % NN cord-010119-t1x9gknd 5416 31 of of IN cord-010119-t1x9gknd 5416 32 nonsurgical nonsurgical JJ cord-010119-t1x9gknd 5416 33 blood blood NN cord-010119-t1x9gknd 5416 34 use use NN cord-010119-t1x9gknd 5416 35 ( ( -LRB- cord-010119-t1x9gknd 5416 36 P50.003 p50.003 NN cord-010119-t1x9gknd 5416 37 by by IN cord-010119-t1x9gknd 5416 38 t t NN cord-010119-t1x9gknd 5416 39 - - HYPH cord-010119-t1x9gknd 5416 40 test test NN cord-010119-t1x9gknd 5416 41 ) ) -RRB- cord-010119-t1x9gknd 5416 42 . . . cord-010119-t1x9gknd 5417 1 Non non JJ cord-010119-t1x9gknd 5417 2 - - JJ cord-010119-t1x9gknd 5417 3 surgical surgical JJ cord-010119-t1x9gknd 5417 4 RBC RBC NNP cord-010119-t1x9gknd 5417 5 use use NN cord-010119-t1x9gknd 5417 6 now now RB cord-010119-t1x9gknd 5417 7 represents represent VBZ cord-010119-t1x9gknd 5417 8 approximately approximately RB cord-010119-t1x9gknd 5417 9 29 29 CD cord-010119-t1x9gknd 5417 10 % % NN cord-010119-t1x9gknd 5417 11 of of IN cord-010119-t1x9gknd 5417 12 the the DT cord-010119-t1x9gknd 5417 13 total total JJ cord-010119-t1x9gknd 5417 14 RBC RBC NNP cord-010119-t1x9gknd 5417 15 use use NN cord-010119-t1x9gknd 5417 16 hospital hospital NN cord-010119-t1x9gknd 5417 17 wide wide RB cord-010119-t1x9gknd 5417 18 a a DT cord-010119-t1x9gknd 5417 19 13 13 CD cord-010119-t1x9gknd 5417 20 % % NN cord-010119-t1x9gknd 5417 21 reduction reduction NN cord-010119-t1x9gknd 5417 22 . . . cord-010119-t1x9gknd 5418 1 This this DT cord-010119-t1x9gknd 5418 2 change change NN cord-010119-t1x9gknd 5418 3 represents represent VBZ cord-010119-t1x9gknd 5418 4 a a DT cord-010119-t1x9gknd 5418 5 significant significant JJ cord-010119-t1x9gknd 5418 6 cost cost NN cord-010119-t1x9gknd 5418 7 savings saving NNS cord-010119-t1x9gknd 5418 8 in in IN cord-010119-t1x9gknd 5418 9 RBCs rbc NNS cord-010119-t1x9gknd 5418 10 over over IN cord-010119-t1x9gknd 5418 11 time time NN cord-010119-t1x9gknd 5418 12 . . . cord-010119-t1x9gknd 5419 1 Conclusion conclusion NN cord-010119-t1x9gknd 5419 2 : : : cord-010119-t1x9gknd 5420 1 The the DT cord-010119-t1x9gknd 5420 2 use use NN cord-010119-t1x9gknd 5420 3 of of IN cord-010119-t1x9gknd 5420 4 target target NN cord-010119-t1x9gknd 5420 5 based base VBN cord-010119-t1x9gknd 5420 6 transfusion transfusion NN cord-010119-t1x9gknd 5420 7 indications indication NNS cord-010119-t1x9gknd 5420 8 and and CC cord-010119-t1x9gknd 5420 9 an an DT cord-010119-t1x9gknd 5420 10 electronic electronic JJ cord-010119-t1x9gknd 5420 11 decision decision NN cord-010119-t1x9gknd 5420 12 support support NN cord-010119-t1x9gknd 5420 13 algorithm algorithm NN cord-010119-t1x9gknd 5420 14 to to TO cord-010119-t1x9gknd 5420 15 calculate calculate VB cord-010119-t1x9gknd 5420 16 a a DT cord-010119-t1x9gknd 5420 17 recommended recommend VBN cord-010119-t1x9gknd 5420 18 transfusion transfusion NN cord-010119-t1x9gknd 5420 19 dose dose NN cord-010119-t1x9gknd 5420 20 can can MD cord-010119-t1x9gknd 5420 21 significantly significantly RB cord-010119-t1x9gknd 5420 22 reduce reduce VB cord-010119-t1x9gknd 5420 23 the the DT cord-010119-t1x9gknd 5420 24 non non JJ cord-010119-t1x9gknd 5420 25 - - JJ cord-010119-t1x9gknd 5420 26 surgical surgical JJ cord-010119-t1x9gknd 5420 27 RBC RBC NNP cord-010119-t1x9gknd 5420 28 transfusion transfusion NN cord-010119-t1x9gknd 5420 29 rate rate NN cord-010119-t1x9gknd 5420 30 providing provide VBG cord-010119-t1x9gknd 5420 31 enhanced enhance VBN cord-010119-t1x9gknd 5420 32 patient patient JJ cord-010119-t1x9gknd 5420 33 blood blood NN cord-010119-t1x9gknd 5420 34 management management NN cord-010119-t1x9gknd 5420 35 and and CC cord-010119-t1x9gknd 5420 36 potential potential JJ cord-010119-t1x9gknd 5420 37 cost cost NN cord-010119-t1x9gknd 5420 38 savings saving NNS cord-010119-t1x9gknd 5420 39 . . . cord-010119-t1x9gknd 5421 1 Implementation implementation NN cord-010119-t1x9gknd 5421 2 of of IN cord-010119-t1x9gknd 5421 3 Patient Patient NNP cord-010119-t1x9gknd 5421 4 Blood Blood NNP cord-010119-t1x9gknd 5421 5 Management Management NNP cord-010119-t1x9gknd 5421 6 at at IN cord-010119-t1x9gknd 5421 7 a a DT cord-010119-t1x9gknd 5421 8 Community Community NNP cord-010119-t1x9gknd 5421 9 Hospital Hospital NNP cord-010119-t1x9gknd 5422 1 -30 -30 NNP cord-010119-t1x9gknd 5422 2 Month Month NNP cord-010119-t1x9gknd 5422 3 Report Report NNP cord-010119-t1x9gknd 5422 4 Card Card NNP cord-010119-t1x9gknd 5422 5 Richard Richard NNP cord-010119-t1x9gknd 5422 6 Gammon Gammon NNP cord-010119-t1x9gknd 5422 7 * * NFP cord-010119-t1x9gknd 5422 8 . . . cord-010119-t1x9gknd 5423 1 Oneblood Oneblood NNP cord-010119-t1x9gknd 5423 2 , , , cord-010119-t1x9gknd 5424 1 Inc. Inc. NNP cord-010119-t1x9gknd 5424 2 Background Background NNP cord-010119-t1x9gknd 5424 3 / / SYM cord-010119-t1x9gknd 5424 4 Case Case NNP cord-010119-t1x9gknd 5424 5 Studies Studies NNPS cord-010119-t1x9gknd 5424 6 : : : cord-010119-t1x9gknd 5424 7 A a DT cord-010119-t1x9gknd 5424 8 collaboration collaboration NN cord-010119-t1x9gknd 5424 9 between between IN cord-010119-t1x9gknd 5424 10 blood blood NN cord-010119-t1x9gknd 5424 11 center center NN cord-010119-t1x9gknd 5424 12 between between IN cord-010119-t1x9gknd 5424 13 ( ( -LRB- cord-010119-t1x9gknd 5424 14 BC BC NNP cord-010119-t1x9gknd 5424 15 ) ) -RRB- cord-010119-t1x9gknd 5424 16 as as IN cord-010119-t1x9gknd 5424 17 consultant consultant NN cord-010119-t1x9gknd 5424 18 and and CC cord-010119-t1x9gknd 5424 19 three three CD cord-010119-t1x9gknd 5424 20 hospital hospital NN cord-010119-t1x9gknd 5424 21 ( ( -LRB- cord-010119-t1x9gknd 5424 22 4001 4001 CD cord-010119-t1x9gknd 5424 23 beds bed NNS cord-010119-t1x9gknd 5424 24 ) ) -RRB- cord-010119-t1x9gknd 5425 1 healthcare healthcare NN cord-010119-t1x9gknd 5425 2 system system NN cord-010119-t1x9gknd 5425 3 ( ( -LRB- cord-010119-t1x9gknd 5425 4 HCS HCS NNP cord-010119-t1x9gknd 5425 5 ) ) -RRB- cord-010119-t1x9gknd 5426 1 to to TO cord-010119-t1x9gknd 5426 2 implement implement VB cord-010119-t1x9gknd 5426 3 a a DT cord-010119-t1x9gknd 5426 4 patient patient JJ cord-010119-t1x9gknd 5426 5 blood blood NN cord-010119-t1x9gknd 5426 6 management management NN cord-010119-t1x9gknd 5426 7 ( ( -LRB- cord-010119-t1x9gknd 5426 8 PBM PBM NNP cord-010119-t1x9gknd 5426 9 ) ) -RRB- cord-010119-t1x9gknd 5426 10 program program NN cord-010119-t1x9gknd 5426 11 was be VBD cord-010119-t1x9gknd 5426 12 undertaken undertake VBN cord-010119-t1x9gknd 5426 13 . . . cord-010119-t1x9gknd 5427 1 This this DT cord-010119-t1x9gknd 5427 2 is be VBZ cord-010119-t1x9gknd 5427 3 a a DT cord-010119-t1x9gknd 5427 4 review review NN cord-010119-t1x9gknd 5427 5 of of IN cord-010119-t1x9gknd 5427 6 the the DT cord-010119-t1x9gknd 5427 7 first first JJ cord-010119-t1x9gknd 5427 8 30 30 CD cord-010119-t1x9gknd 5427 9 months month NNS cord-010119-t1x9gknd 5427 10 . . . cord-010119-t1x9gknd 5428 1 Study Study NNP cord-010119-t1x9gknd 5428 2 Design Design NNP cord-010119-t1x9gknd 5428 3 / / SYM cord-010119-t1x9gknd 5428 4 Method method NN cord-010119-t1x9gknd 5428 5 : : : cord-010119-t1x9gknd 5428 6 During during IN cord-010119-t1x9gknd 5428 7 year year NN cord-010119-t1x9gknd 5428 8 one one CD cord-010119-t1x9gknd 5428 9 PBM PBM NNP cord-010119-t1x9gknd 5428 10 working working NN cord-010119-t1x9gknd 5428 11 group group NN cord-010119-t1x9gknd 5428 12 was be VBD cord-010119-t1x9gknd 5428 13 established establish VBN cord-010119-t1x9gknd 5428 14 . . . cord-010119-t1x9gknd 5429 1 Achievements achievement NNS cord-010119-t1x9gknd 5429 2 included include VBD cord-010119-t1x9gknd 5429 3 physician physician NN cord-010119-t1x9gknd 5429 4 engagement engagement NN cord-010119-t1x9gknd 5429 5 programs program NNS cord-010119-t1x9gknd 5429 6 , , , cord-010119-t1x9gknd 5429 7 creation creation NN cord-010119-t1x9gknd 5429 8 of of IN cord-010119-t1x9gknd 5429 9 transfusion transfusion NN cord-010119-t1x9gknd 5429 10 committee committee NN cord-010119-t1x9gknd 5429 11 and and CC cord-010119-t1x9gknd 5429 12 providing provide VBG cord-010119-t1x9gknd 5429 13 nursing nursing NN cord-010119-t1x9gknd 5429 14 education education NN cord-010119-t1x9gknd 5429 15 . . . cord-010119-t1x9gknd 5430 1 Auditing auditing NN cord-010119-t1x9gknd 5430 2 processes process NNS cord-010119-t1x9gknd 5430 3 were be VBD cord-010119-t1x9gknd 5430 4 implemented implement VBN cord-010119-t1x9gknd 5430 5 with with IN cord-010119-t1x9gknd 5430 6 nonconformance nonconformance NNP cord-010119-t1x9gknd 5430 7 letters letter NNS cord-010119-t1x9gknd 5430 8 sent send VBN cord-010119-t1x9gknd 5430 9 to to IN cord-010119-t1x9gknd 5430 10 physicians physician NNS cord-010119-t1x9gknd 5430 11 and and CC cord-010119-t1x9gknd 5430 12 nurses nurse NNS cord-010119-t1x9gknd 5430 13 when when WRB cord-010119-t1x9gknd 5430 14 compliance compliance NN cord-010119-t1x9gknd 5430 15 with with IN cord-010119-t1x9gknd 5430 16 informed informed JJ cord-010119-t1x9gknd 5430 17 consent consent NN cord-010119-t1x9gknd 5430 18 , , , cord-010119-t1x9gknd 5430 19 transfusion transfusion NN cord-010119-t1x9gknd 5430 20 tags tag NNS cord-010119-t1x9gknd 5430 21 and and CC cord-010119-t1x9gknd 5430 22 thresholds threshold NNS cord-010119-t1x9gknd 5430 23 and and CC cord-010119-t1x9gknd 5430 24 discharge discharge NN cord-010119-t1x9gknd 5430 25 instructions instruction NNS cord-010119-t1x9gknd 5430 26 was be VBD cord-010119-t1x9gknd 5430 27 not not RB cord-010119-t1x9gknd 5430 28 achieved achieve VBN cord-010119-t1x9gknd 5430 29 . . . cord-010119-t1x9gknd 5431 1 In in IN cord-010119-t1x9gknd 5431 2 year year NN cord-010119-t1x9gknd 5431 3 two two CD cord-010119-t1x9gknd 5431 4 , , , cord-010119-t1x9gknd 5431 5 IT it PRP cord-010119-t1x9gknd 5431 6 created create VBD cord-010119-t1x9gknd 5431 7 best good JJS cord-010119-t1x9gknd 5431 8 practice practice NN cord-010119-t1x9gknd 5431 9 alerts alert NNS cord-010119-t1x9gknd 5431 10 ( ( -LRB- cord-010119-t1x9gknd 5431 11 BPA BPA NNP cord-010119-t1x9gknd 5431 12 ) ) -RRB- cord-010119-t1x9gknd 5431 13 when when WRB cord-010119-t1x9gknd 5431 14 an an DT cord-010119-t1x9gknd 5431 15 order order NN cord-010119-t1x9gknd 5431 16 did do VBD cord-010119-t1x9gknd 5431 17 not not RB cord-010119-t1x9gknd 5431 18 meet meet VB cord-010119-t1x9gknd 5431 19 transfusion transfusion NN cord-010119-t1x9gknd 5431 20 threshold threshold NN cord-010119-t1x9gknd 5431 21 criteria criterion NNS cord-010119-t1x9gknd 5431 22 . . . cord-010119-t1x9gknd 5432 1 BPA BPA NNP cord-010119-t1x9gknd 5432 2 showed show VBD cord-010119-t1x9gknd 5432 3 first first JJ cord-010119-t1x9gknd 5432 4 line line NN cord-010119-t1x9gknd 5432 5 of of IN cord-010119-t1x9gknd 5432 6 associated associate VBN cord-010119-t1x9gknd 5432 7 procedure procedure NN cord-010119-t1x9gknd 5432 8 , , , cord-010119-t1x9gknd 5432 9 link link VBP cord-010119-t1x9gknd 5432 10 to to IN cord-010119-t1x9gknd 5432 11 the the DT cord-010119-t1x9gknd 5432 12 full full JJ cord-010119-t1x9gknd 5432 13 procedure procedure NN cord-010119-t1x9gknd 5432 14 , , , cord-010119-t1x9gknd 5432 15 three three CD cord-010119-t1x9gknd 5432 16 most most RBS cord-010119-t1x9gknd 5432 17 recent recent JJ cord-010119-t1x9gknd 5432 18 lab lab NN cord-010119-t1x9gknd 5432 19 results result NNS cord-010119-t1x9gknd 5432 20 ( ( -LRB- cord-010119-t1x9gknd 5432 21 e.g. e.g. RB cord-010119-t1x9gknd 5432 22 , , , cord-010119-t1x9gknd 5432 23 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5432 24 & & CC cord-010119-t1x9gknd 5432 25 hematocrit hematocrit NN cord-010119-t1x9gknd 5432 26 for for IN cord-010119-t1x9gknd 5432 27 red red JJ cord-010119-t1x9gknd 5432 28 blood blood NN cord-010119-t1x9gknd 5432 29 cells cell NNS cord-010119-t1x9gknd 5432 30 ( ( -LRB- cord-010119-t1x9gknd 5432 31 RBC RBC NNP cord-010119-t1x9gknd 5432 32 ) ) -RRB- cord-010119-t1x9gknd 5432 33 ) ) -RRB- cord-010119-t1x9gknd 5432 34 and and CC cord-010119-t1x9gknd 5432 35 allowed allow VBD cord-010119-t1x9gknd 5432 36 ordering order VBG cord-010119-t1x9gknd 5432 37 physician physician NN cord-010119-t1x9gknd 5432 38 to to TO cord-010119-t1x9gknd 5432 39 cancel cancel VB cord-010119-t1x9gknd 5432 40 order order NN cord-010119-t1x9gknd 5432 41 after after IN cord-010119-t1x9gknd 5432 42 review review NN cord-010119-t1x9gknd 5432 43 . . . cord-010119-t1x9gknd 5433 1 A a DT cord-010119-t1x9gknd 5433 2 blood blood NN cord-010119-t1x9gknd 5433 3 administration administration NN cord-010119-t1x9gknd 5433 4 video video NN cord-010119-t1x9gknd 5433 5 was be VBD cord-010119-t1x9gknd 5433 6 created create VBN cord-010119-t1x9gknd 5433 7 . . . cord-010119-t1x9gknd 5434 1 It -PRON- PRP cord-010119-t1x9gknd 5434 2 was be VBD cord-010119-t1x9gknd 5434 3 mandatory mandatory JJ cord-010119-t1x9gknd 5434 4 that that IN cord-010119-t1x9gknd 5434 5 all all DT cord-010119-t1x9gknd 5434 6 physicians physician NNS cord-010119-t1x9gknd 5434 7 granted grant VBD cord-010119-t1x9gknd 5434 8 privileges privilege NNS cord-010119-t1x9gknd 5434 9 complete complete JJ cord-010119-t1x9gknd 5434 10 within within IN cord-010119-t1x9gknd 5434 11 six six CD cord-010119-t1x9gknd 5434 12 months month NNS cord-010119-t1x9gknd 5434 13 . . . cord-010119-t1x9gknd 5435 1 Low low JJ cord-010119-t1x9gknd 5435 2 vital vital JJ cord-010119-t1x9gknd 5435 3 sign sign NN cord-010119-t1x9gknd 5435 4 compliance compliance NN cord-010119-t1x9gknd 5435 5 required require VBD cord-010119-t1x9gknd 5435 6 action action NN cord-010119-t1x9gknd 5435 7 that that WDT cord-010119-t1x9gknd 5435 8 included include VBD cord-010119-t1x9gknd 5435 9 reducing reduce VBG cord-010119-t1x9gknd 5435 10 requirement requirement NN cord-010119-t1x9gknd 5435 11 from from IN cord-010119-t1x9gknd 5435 12 five five CD cord-010119-t1x9gknd 5435 13 to to TO cord-010119-t1x9gknd 5435 14 three three CD cord-010119-t1x9gknd 5435 15 during during IN cord-010119-t1x9gknd 5435 16 transfusion transfusion NN cord-010119-t1x9gknd 5435 17 and and CC cord-010119-t1x9gknd 5435 18 formation formation NN cord-010119-t1x9gknd 5435 19 of of IN cord-010119-t1x9gknd 5435 20 working work VBG cord-010119-t1x9gknd 5435 21 group group NN cord-010119-t1x9gknd 5435 22 ( ( -LRB- cord-010119-t1x9gknd 5435 23 WG WG NNP cord-010119-t1x9gknd 5435 24 ) ) -RRB- cord-010119-t1x9gknd 5435 25 to to TO cord-010119-t1x9gknd 5435 26 address address VB cord-010119-t1x9gknd 5435 27 knowledge knowledge NN cord-010119-t1x9gknd 5435 28 and and CC cord-010119-t1x9gknd 5435 29 practice practice NN cord-010119-t1x9gknd 5435 30 gaps gap NNS cord-010119-t1x9gknd 5435 31 . . . cord-010119-t1x9gknd 5436 1 In in IN cord-010119-t1x9gknd 5436 2 year year NN cord-010119-t1x9gknd 5436 3 three three CD cord-010119-t1x9gknd 5436 4 , , , cord-010119-t1x9gknd 5436 5 as as RB cord-010119-t1x9gknd 5436 6 historically historically RB cord-010119-t1x9gknd 5436 7 at at IN cord-010119-t1x9gknd 5436 8 this this DT cord-010119-t1x9gknd 5436 9 HCS HCS NNP cord-010119-t1x9gknd 5436 10 very very RB cord-010119-t1x9gknd 5436 11 few few JJ cord-010119-t1x9gknd 5436 12 Jehovah Jehovah NNP cord-010119-t1x9gknd 5436 13 's 's POS cord-010119-t1x9gknd 5436 14 Witness Witness NNP cord-010119-t1x9gknd 5436 15 patients patient NNS cord-010119-t1x9gknd 5436 16 ( ( -LRB- cord-010119-t1x9gknd 5436 17 JWP JWP NNP cord-010119-t1x9gknd 5436 18 ) ) -RRB- cord-010119-t1x9gknd 5436 19 presented present VBD cord-010119-t1x9gknd 5436 20 , , , cord-010119-t1x9gknd 5436 21 PBM PBM NNP cord-010119-t1x9gknd 5436 22 WG WG NNP cord-010119-t1x9gknd 5436 23 was be VBD cord-010119-t1x9gknd 5436 24 involved involve VBN cord-010119-t1x9gknd 5436 25 with with IN cord-010119-t1x9gknd 5436 26 implementation implementation NN cord-010119-t1x9gknd 5436 27 of of IN cord-010119-t1x9gknd 5436 28 a a DT cord-010119-t1x9gknd 5436 29 bloodless bloodless JJ cord-010119-t1x9gknd 5436 30 medicine medicine NN cord-010119-t1x9gknd 5436 31 program program NN cord-010119-t1x9gknd 5436 32 . . . cord-010119-t1x9gknd 5437 1 All all DT cord-010119-t1x9gknd 5437 2 steps step NNS cord-010119-t1x9gknd 5437 3 of of IN cord-010119-t1x9gknd 5437 4 care care NN cord-010119-t1x9gknd 5437 5 were be VBD cord-010119-t1x9gknd 5437 6 addressed address VBN cord-010119-t1x9gknd 5437 7 including include VBG cord-010119-t1x9gknd 5437 8 identifying identify VBG cord-010119-t1x9gknd 5437 9 JWP JWP NNP cord-010119-t1x9gknd 5437 10 at at IN cord-010119-t1x9gknd 5437 11 registration registration NN cord-010119-t1x9gknd 5437 12 , , , cord-010119-t1x9gknd 5437 13 creating create VBG cord-010119-t1x9gknd 5437 14 115A 115a CD cord-010119-t1x9gknd 5437 15 TRANSFUSION transfusion NN cord-010119-t1x9gknd 5437 16 special special JJ cord-010119-t1x9gknd 5437 17 arm arm NN cord-010119-t1x9gknd 5437 18 bands band NNS cord-010119-t1x9gknd 5437 19 , , , cord-010119-t1x9gknd 5437 20 forming form VBG cord-010119-t1x9gknd 5437 21 a a DT cord-010119-t1x9gknd 5437 22 bloodless bloodless JJ cord-010119-t1x9gknd 5437 23 medicine medicine NN cord-010119-t1x9gknd 5437 24 physician physician NN cord-010119-t1x9gknd 5437 25 group group NN cord-010119-t1x9gknd 5437 26 , , , cord-010119-t1x9gknd 5437 27 implementing implement VBG cord-010119-t1x9gknd 5437 28 nursing nurse VBG cord-010119-t1x9gknd 5437 29 BPA BPA NNP cord-010119-t1x9gknd 5437 30 in in IN cord-010119-t1x9gknd 5437 31 the the DT cord-010119-t1x9gknd 5437 32 electronic electronic JJ cord-010119-t1x9gknd 5437 33 medical medical JJ cord-010119-t1x9gknd 5437 34 record record NN cord-010119-t1x9gknd 5437 35 , , , cord-010119-t1x9gknd 5437 36 creating create VBG cord-010119-t1x9gknd 5437 37 advanced advanced JJ cord-010119-t1x9gknd 5437 38 directives directive NNS cord-010119-t1x9gknd 5437 39 and and CC cord-010119-t1x9gknd 5437 40 marketing marketing NN cord-010119-t1x9gknd 5437 41 to to IN cord-010119-t1x9gknd 5437 42 the the DT cord-010119-t1x9gknd 5437 43 public public NN cord-010119-t1x9gknd 5437 44 . . . cord-010119-t1x9gknd 5438 1 Results/ Results/ . cord-010119-t1x9gknd 5439 1 Finding find VBG cord-010119-t1x9gknd 5439 2 : : : cord-010119-t1x9gknd 5439 3 The the DT cord-010119-t1x9gknd 5439 4 following follow VBG cord-010119-t1x9gknd 5439 5 were be VBD cord-010119-t1x9gknd 5439 6 monitored monitor VBN cord-010119-t1x9gknd 5439 7 for for IN cord-010119-t1x9gknd 5439 8 compliance compliance NN cord-010119-t1x9gknd 5439 9 ( ( -LRB- cord-010119-t1x9gknd 5439 10 2Q14 2q14 CD cord-010119-t1x9gknd 5439 11 vs. vs. IN cord-010119-t1x9gknd 5439 12 1Q17 1q17 CD cord-010119-t1x9gknd 5439 13 ) ) -RRB- cord-010119-t1x9gknd 5439 14 : : : cord-010119-t1x9gknd 5439 15 present present JJ cord-010119-t1x9gknd 5439 16 and and CC cord-010119-t1x9gknd 5439 17 completed complete VBN cord-010119-t1x9gknd 5439 18 consents consent NNS cord-010119-t1x9gknd 5439 19 ( ( -LRB- cord-010119-t1x9gknd 5439 20 66 66 CD cord-010119-t1x9gknd 5439 21 vs. vs. NN cord-010119-t1x9gknd 5439 22 94 94 CD cord-010119-t1x9gknd 5439 23 % % NN cord-010119-t1x9gknd 5439 24 ) ) -RRB- cord-010119-t1x9gknd 5439 25 , , , cord-010119-t1x9gknd 5439 26 present present JJ cord-010119-t1x9gknd 5439 27 and and CC cord-010119-t1x9gknd 5439 28 completed complete VBN cord-010119-t1x9gknd 5439 29 nursing nursing NN cord-010119-t1x9gknd 5439 30 flow flow NN cord-010119-t1x9gknd 5439 31 sheets sheet NNS cord-010119-t1x9gknd 5439 32 ( ( -LRB- cord-010119-t1x9gknd 5439 33 19 19 CD cord-010119-t1x9gknd 5439 34 vs. vs. IN cord-010119-t1x9gknd 5439 35 96 96 CD cord-010119-t1x9gknd 5439 36 % % NN cord-010119-t1x9gknd 5439 37 ) ) -RRB- cord-010119-t1x9gknd 5439 38 , , , cord-010119-t1x9gknd 5439 39 transfusion transfusion NN cord-010119-t1x9gknd 5439 40 thresholds threshold NNS cord-010119-t1x9gknd 5439 41 supported support VBN cord-010119-t1x9gknd 5439 42 ( ( -LRB- cord-010119-t1x9gknd 5439 43 73 73 CD cord-010119-t1x9gknd 5439 44 vs. vs. NN cord-010119-t1x9gknd 5439 45 100 100 CD cord-010119-t1x9gknd 5439 46 % % NN cord-010119-t1x9gknd 5439 47 ) ) -RRB- cord-010119-t1x9gknd 5439 48 , , , cord-010119-t1x9gknd 5439 49 discharge discharge NN cord-010119-t1x9gknd 5439 50 instructions instruction NNS cord-010119-t1x9gknd 5439 51 provided provide VBN cord-010119-t1x9gknd 5439 52 ( ( -LRB- cord-010119-t1x9gknd 5439 53 17 17 CD cord-010119-t1x9gknd 5439 54 vs. vs. NN cord-010119-t1x9gknd 5439 55 86 86 CD cord-010119-t1x9gknd 5439 56 % % NN cord-010119-t1x9gknd 5439 57 ) ) -RRB- cord-010119-t1x9gknd 5439 58 ; ; : cord-010119-t1x9gknd 5439 59 ( ( -LRB- cord-010119-t1x9gknd 5439 60 3Q15 3q15 CD cord-010119-t1x9gknd 5439 61 vs.1Q17 vs.1Q17 NNP cord-010119-t1x9gknd 5439 62 ) ) -RRB- cord-010119-t1x9gknd 5439 63 vital vital JJ cord-010119-t1x9gknd 5439 64 sign sign NN cord-010119-t1x9gknd 5439 65 compliance compliance NN cord-010119-t1x9gknd 5439 66 ( ( -LRB- cord-010119-t1x9gknd 5439 67 39 39 CD cord-010119-t1x9gknd 5439 68 % % NN cord-010119-t1x9gknd 5439 69 vs.71 vs.71 NNP cord-010119-t1x9gknd 5439 70 % % NN cord-010119-t1x9gknd 5439 71 ) ) -RRB- cord-010119-t1x9gknd 5439 72 . . . cord-010119-t1x9gknd 5440 1 JWP JWP NNP cord-010119-t1x9gknd 5440 2 increased increase VBD cord-010119-t1x9gknd 5440 3 from from IN cord-010119-t1x9gknd 5440 4 27 27 CD cord-010119-t1x9gknd 5440 5 to to IN cord-010119-t1x9gknd 5440 6 225 225 CD cord-010119-t1x9gknd 5440 7 ( ( -LRB- cord-010119-t1x9gknd 5440 8 04/16 04/16 CD cord-010119-t1x9gknd 5440 9 - - SYM cord-010119-t1x9gknd 5440 10 03/17 03/17 CD cord-010119-t1x9gknd 5440 11 ) ) -RRB- cord-010119-t1x9gknd 5440 12 . . . cord-010119-t1x9gknd 5441 1 Cost cost NN cord-010119-t1x9gknd 5441 2 savings saving NNS cord-010119-t1x9gknd 5441 3 were be VBD cord-010119-t1x9gknd 5441 4 realized realize VBN cord-010119-t1x9gknd 5441 5 by by IN cord-010119-t1x9gknd 5441 6 decreased decreased JJ cord-010119-t1x9gknd 5441 7 utilization utilization NN cord-010119-t1x9gknd 5441 8 and and CC cord-010119-t1x9gknd 5441 9 implementation implementation NN cord-010119-t1x9gknd 5441 10 of of IN cord-010119-t1x9gknd 5441 11 BPA BPA NNP cord-010119-t1x9gknd 5441 12 . . . cord-010119-t1x9gknd 5442 1 ( ( -LRB- cord-010119-t1x9gknd 5442 2 Table table NN cord-010119-t1x9gknd 5442 3 2016 2016 CD cord-010119-t1x9gknd 5443 1 -1Q17 -1q17 LS cord-010119-t1x9gknd 5443 2 ) ) -RRB- cord-010119-t1x9gknd 5443 3 Conclusion conclusion NN cord-010119-t1x9gknd 5443 4 : : : cord-010119-t1x9gknd 5443 5 PBM PBM NNP cord-010119-t1x9gknd 5443 6 implementation implementation NN cord-010119-t1x9gknd 5443 7 at at IN cord-010119-t1x9gknd 5443 8 a a DT cord-010119-t1x9gknd 5443 9 HCS HCS NNP cord-010119-t1x9gknd 5443 10 is be VBZ cord-010119-t1x9gknd 5443 11 a a DT cord-010119-t1x9gknd 5443 12 continuous continuous JJ cord-010119-t1x9gknd 5443 13 and and CC cord-010119-t1x9gknd 5443 14 multiyear multiyear JJ cord-010119-t1x9gknd 5443 15 process process NN cord-010119-t1x9gknd 5443 16 . . . cord-010119-t1x9gknd 5444 1 Even even RB cord-010119-t1x9gknd 5444 2 with with IN cord-010119-t1x9gknd 5444 3 a a DT cord-010119-t1x9gknd 5444 4 robust robust JJ cord-010119-t1x9gknd 5444 5 program program NN cord-010119-t1x9gknd 5444 6 challenges challenge NNS cord-010119-t1x9gknd 5444 7 such such JJ cord-010119-t1x9gknd 5444 8 as as IN cord-010119-t1x9gknd 5444 9 vital vital JJ cord-010119-t1x9gknd 5444 10 sign sign NN cord-010119-t1x9gknd 5444 11 compliance compliance NN cord-010119-t1x9gknd 5444 12 remain remain VBP cord-010119-t1x9gknd 5444 13 . . . cord-010119-t1x9gknd 5445 1 Improving improve VBG cord-010119-t1x9gknd 5445 2 Patient Patient NNP cord-010119-t1x9gknd 5445 3 Outcomes Outcomes NNPS cord-010119-t1x9gknd 5445 4 in in IN cord-010119-t1x9gknd 5445 5 the the DT cord-010119-t1x9gknd 5445 6 Golden Golden NNP cord-010119-t1x9gknd 5445 7 - - HYPH cord-010119-t1x9gknd 5445 8 Hour Hour NNP cord-010119-t1x9gknd 5445 9 Beatrice Beatrice NNP cord-010119-t1x9gknd 5445 10 LeBeuf lebeuf NN cord-010119-t1x9gknd 5446 1 * * NFP cord-010119-t1x9gknd 5446 2 . . . cord-010119-t1x9gknd 5447 1 Medical Medical NNP cord-010119-t1x9gknd 5447 2 City City NNP cord-010119-t1x9gknd 5447 3 Plano Plano NNP cord-010119-t1x9gknd 5447 4 Background Background NNP cord-010119-t1x9gknd 5447 5 / / SYM cord-010119-t1x9gknd 5447 6 Case Case NNP cord-010119-t1x9gknd 5447 7 Studies Studies NNPS cord-010119-t1x9gknd 5447 8 : : : cord-010119-t1x9gknd 5448 1 In in IN cord-010119-t1x9gknd 5448 2 emergency emergency NN cord-010119-t1x9gknd 5448 3 medicine medicine NN cord-010119-t1x9gknd 5448 4 , , , cord-010119-t1x9gknd 5448 5 " " '' cord-010119-t1x9gknd 5448 6 the the DT cord-010119-t1x9gknd 5448 7 golden golden JJ cord-010119-t1x9gknd 5448 8 hour hour NN cord-010119-t1x9gknd 5448 9 " " '' cord-010119-t1x9gknd 5448 10 refers refer VBZ cord-010119-t1x9gknd 5448 11 to to IN cord-010119-t1x9gknd 5448 12 the the DT cord-010119-t1x9gknd 5448 13 critical critical JJ cord-010119-t1x9gknd 5448 14 one one CD cord-010119-t1x9gknd 5448 15 - - HYPH cord-010119-t1x9gknd 5448 16 hour hour NN cord-010119-t1x9gknd 5448 17 time time NN cord-010119-t1x9gknd 5448 18 period period NN cord-010119-t1x9gknd 5448 19 following follow VBG cord-010119-t1x9gknd 5448 20 traumatic traumatic JJ cord-010119-t1x9gknd 5448 21 injury injury NN cord-010119-t1x9gknd 5448 22 in in IN cord-010119-t1x9gknd 5448 23 which which WDT cord-010119-t1x9gknd 5448 24 the the DT cord-010119-t1x9gknd 5448 25 patient patient NN cord-010119-t1x9gknd 5448 26 has have VBZ cord-010119-t1x9gknd 5448 27 a a DT cord-010119-t1x9gknd 5448 28 higher high JJR cord-010119-t1x9gknd 5448 29 likelihood likelihood NN cord-010119-t1x9gknd 5448 30 of of IN cord-010119-t1x9gknd 5448 31 survival survival NN cord-010119-t1x9gknd 5448 32 . . . cord-010119-t1x9gknd 5449 1 Nearly nearly RB cord-010119-t1x9gknd 5449 2 half half NN cord-010119-t1x9gknd 5449 3 of of IN cord-010119-t1x9gknd 5449 4 all all DT cord-010119-t1x9gknd 5449 5 trauma trauma NN cord-010119-t1x9gknd 5449 6 related relate VBN cord-010119-t1x9gknd 5449 7 deaths death NNS cord-010119-t1x9gknd 5449 8 occur occur VBP cord-010119-t1x9gknd 5449 9 in in IN cord-010119-t1x9gknd 5449 10 the the DT cord-010119-t1x9gknd 5449 11 first first JJ cord-010119-t1x9gknd 5449 12 hour hour NN cord-010119-t1x9gknd 5449 13 after after IN cord-010119-t1x9gknd 5449 14 injury injury NN cord-010119-t1x9gknd 5449 15 -half -half NN cord-010119-t1x9gknd 5449 16 of of IN cord-010119-t1x9gknd 5449 17 those those DT cord-010119-t1x9gknd 5449 18 deaths death NNS cord-010119-t1x9gknd 5449 19 are be VBP cord-010119-t1x9gknd 5449 20 the the DT cord-010119-t1x9gknd 5449 21 result result NN cord-010119-t1x9gknd 5449 22 of of IN cord-010119-t1x9gknd 5449 23 major major JJ cord-010119-t1x9gknd 5449 24 hemorrhaging hemorrhaging NN cord-010119-t1x9gknd 5449 25 . . . cord-010119-t1x9gknd 5450 1 Rapid Rapid NNP cord-010119-t1x9gknd 5450 2 administration administration NN cord-010119-t1x9gknd 5450 3 of of IN cord-010119-t1x9gknd 5450 4 blood blood NN cord-010119-t1x9gknd 5450 5 products product NNS cord-010119-t1x9gknd 5450 6 is be VBZ cord-010119-t1x9gknd 5450 7 vital vital JJ cord-010119-t1x9gknd 5450 8 to to IN cord-010119-t1x9gknd 5450 9 the the DT cord-010119-t1x9gknd 5450 10 survival survival NN cord-010119-t1x9gknd 5450 11 of of IN cord-010119-t1x9gknd 5450 12 these these DT cord-010119-t1x9gknd 5450 13 patients patient NNS cord-010119-t1x9gknd 5450 14 . . . cord-010119-t1x9gknd 5451 1 We -PRON- PRP cord-010119-t1x9gknd 5451 2 implemented implement VBD cord-010119-t1x9gknd 5451 3 BloodTrack BloodTrack NNP cord-010119-t1x9gknd 5451 4 Emerge Emerge NNP cord-010119-t1x9gknd 5451 5 ( ( -LRB- cord-010119-t1x9gknd 5451 6 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 5451 7 , , , cord-010119-t1x9gknd 5451 8 Braintree Braintree NNP cord-010119-t1x9gknd 5451 9 , , , cord-010119-t1x9gknd 5451 10 MA MA NNP cord-010119-t1x9gknd 5451 11 ) ) -RRB- cord-010119-t1x9gknd 5451 12 in in IN cord-010119-t1x9gknd 5451 13 our -PRON- PRP$ cord-010119-t1x9gknd 5451 14 Trauma Trauma NNP cord-010119-t1x9gknd 5451 15 emergency emergency NN cord-010119-t1x9gknd 5451 16 department department NN cord-010119-t1x9gknd 5451 17 ( ( -LRB- cord-010119-t1x9gknd 5451 18 ED ED NNP cord-010119-t1x9gknd 5451 19 ) ) -RRB- cord-010119-t1x9gknd 5451 20 as as IN cord-010119-t1x9gknd 5451 21 part part NN cord-010119-t1x9gknd 5451 22 of of IN cord-010119-t1x9gknd 5451 23 a a DT cord-010119-t1x9gknd 5451 24 quality quality NN cord-010119-t1x9gknd 5451 25 improvement improvement NN cord-010119-t1x9gknd 5451 26 initiative initiative NN cord-010119-t1x9gknd 5451 27 to to TO cord-010119-t1x9gknd 5451 28 more more RBR cord-010119-t1x9gknd 5451 29 efficiently efficiently RB cord-010119-t1x9gknd 5451 30 provide provide VB cord-010119-t1x9gknd 5451 31 group group NN cord-010119-t1x9gknd 5451 32 O o NN cord-010119-t1x9gknd 5451 33 RBCs rbc NNS cord-010119-t1x9gknd 5451 34 and and CC cord-010119-t1x9gknd 5451 35 thawed thawed JJ cord-010119-t1x9gknd 5451 36 / / SYM cord-010119-t1x9gknd 5451 37 liquid liquid NN cord-010119-t1x9gknd 5451 38 plasma plasma NN cord-010119-t1x9gknd 5451 39 for for IN cord-010119-t1x9gknd 5451 40 incoming incoming JJ cord-010119-t1x9gknd 5451 41 trauma trauma NN cord-010119-t1x9gknd 5451 42 patients patient NNS cord-010119-t1x9gknd 5451 43 to to TO cord-010119-t1x9gknd 5451 44 support support VB cord-010119-t1x9gknd 5451 45 ratio ratio NN cord-010119-t1x9gknd 5451 46 - - HYPH cord-010119-t1x9gknd 5451 47 based base VBN cord-010119-t1x9gknd 5451 48 transfusions transfusion NNS cord-010119-t1x9gknd 5451 49 and and CC cord-010119-t1x9gknd 5451 50 ensure ensure VB cord-010119-t1x9gknd 5451 51 the the DT cord-010119-t1x9gknd 5451 52 proper proper JJ cord-010119-t1x9gknd 5451 53 handling handling NN cord-010119-t1x9gknd 5451 54 and and CC cord-010119-t1x9gknd 5451 55 traceability traceability NN cord-010119-t1x9gknd 5451 56 of of IN cord-010119-t1x9gknd 5451 57 this this DT cord-010119-t1x9gknd 5451 58 regulated regulated JJ cord-010119-t1x9gknd 5451 59 resource resource NN cord-010119-t1x9gknd 5451 60 . . . cord-010119-t1x9gknd 5452 1 Study Study NNP cord-010119-t1x9gknd 5452 2 Design Design NNP cord-010119-t1x9gknd 5452 3 / / SYM cord-010119-t1x9gknd 5452 4 Methods method NNS cord-010119-t1x9gknd 5452 5 : : : cord-010119-t1x9gknd 5453 1 We -PRON- PRP cord-010119-t1x9gknd 5453 2 treat treat VBP cord-010119-t1x9gknd 5453 3 approximately approximately RB cord-010119-t1x9gknd 5453 4 30 30 CD cord-010119-t1x9gknd 5453 5 - - SYM cord-010119-t1x9gknd 5453 6 40 40 CD cord-010119-t1x9gknd 5453 7 trauma trauma NN cord-010119-t1x9gknd 5453 8 patients patient NNS cord-010119-t1x9gknd 5453 9 monthly monthly RB cord-010119-t1x9gknd 5453 10 . . . cord-010119-t1x9gknd 5454 1 An an DT cord-010119-t1x9gknd 5454 2 assessment assessment NN cord-010119-t1x9gknd 5454 3 of of IN cord-010119-t1x9gknd 5454 4 our -PRON- PRP$ cord-010119-t1x9gknd 5454 5 current current JJ cord-010119-t1x9gknd 5454 6 blood blood NN cord-010119-t1x9gknd 5454 7 supply supply NN cord-010119-t1x9gknd 5454 8 chain chain NN cord-010119-t1x9gknd 5454 9 revealed reveal VBD cord-010119-t1x9gknd 5454 10 a a DT cord-010119-t1x9gknd 5454 11 multistep multistep NN cord-010119-t1x9gknd 5454 12 , , , cord-010119-t1x9gknd 5454 13 manual manual JJ cord-010119-t1x9gknd 5454 14 process process NN cord-010119-t1x9gknd 5454 15 that that WDT cord-010119-t1x9gknd 5454 16 took take VBD cord-010119-t1x9gknd 5454 17 about about RB cord-010119-t1x9gknd 5454 18 8 8 CD cord-010119-t1x9gknd 5454 19 minutes minute NNS cord-010119-t1x9gknd 5454 20 to to TO cord-010119-t1x9gknd 5454 21 prepare prepare VB cord-010119-t1x9gknd 5454 22 and and CC cord-010119-t1x9gknd 5454 23 physically physically RB cord-010119-t1x9gknd 5454 24 transport transport VB cord-010119-t1x9gknd 5454 25 a a DT cord-010119-t1x9gknd 5454 26 cooler cooler NN cord-010119-t1x9gknd 5454 27 from from IN cord-010119-t1x9gknd 5454 28 the the DT cord-010119-t1x9gknd 5454 29 blood blood NN cord-010119-t1x9gknd 5454 30 bank bank NN cord-010119-t1x9gknd 5454 31 to to IN cord-010119-t1x9gknd 5454 32 the the DT cord-010119-t1x9gknd 5454 33 ED ED NNP cord-010119-t1x9gknd 5454 34 . . . cord-010119-t1x9gknd 5455 1 Coolers cooler NNS cord-010119-t1x9gknd 5455 2 of of IN cord-010119-t1x9gknd 5455 3 blood blood NN cord-010119-t1x9gknd 5455 4 were be VBD cord-010119-t1x9gknd 5455 5 provided provide VBN cord-010119-t1x9gknd 5455 6 for for IN cord-010119-t1x9gknd 5455 7 incoming incoming JJ cord-010119-t1x9gknd 5455 8 trauma trauma NN cord-010119-t1x9gknd 5455 9 patients patient NNS cord-010119-t1x9gknd 5455 10 , , , cord-010119-t1x9gknd 5455 11 whether whether IN cord-010119-t1x9gknd 5455 12 they -PRON- PRP cord-010119-t1x9gknd 5455 13 ended end VBD cord-010119-t1x9gknd 5455 14 up up RP cord-010119-t1x9gknd 5455 15 needing need VBG cord-010119-t1x9gknd 5455 16 transfusions transfusion NNS cord-010119-t1x9gknd 5455 17 or or CC cord-010119-t1x9gknd 5455 18 not not RB cord-010119-t1x9gknd 5455 19 . . . cord-010119-t1x9gknd 5456 1 This this DT cord-010119-t1x9gknd 5456 2 practice practice NN cord-010119-t1x9gknd 5456 3 worked work VBD cord-010119-t1x9gknd 5456 4 to to TO cord-010119-t1x9gknd 5456 5 ensure ensure VB cord-010119-t1x9gknd 5456 6 available available JJ cord-010119-t1x9gknd 5456 7 blood blood NN cord-010119-t1x9gknd 5456 8 supplies supply NNS cord-010119-t1x9gknd 5456 9 during during IN cord-010119-t1x9gknd 5456 10 critical critical JJ cord-010119-t1x9gknd 5456 11 moments moment NNS cord-010119-t1x9gknd 5456 12 , , , cord-010119-t1x9gknd 5456 13 but but CC cord-010119-t1x9gknd 5456 14 resulted result VBD cord-010119-t1x9gknd 5456 15 in in IN cord-010119-t1x9gknd 5456 16 inefficiencies inefficiency NNS cord-010119-t1x9gknd 5456 17 and and CC cord-010119-t1x9gknd 5456 18 unnecessary unnecessary JJ cord-010119-t1x9gknd 5456 19 inventory inventory NN cord-010119-t1x9gknd 5456 20 tie tie NN cord-010119-t1x9gknd 5456 21 - - HYPH cord-010119-t1x9gknd 5456 22 ups up NNS cord-010119-t1x9gknd 5456 23 , , , cord-010119-t1x9gknd 5456 24 with with IN cord-010119-t1x9gknd 5456 25 only only RB cord-010119-t1x9gknd 5456 26 10 10 CD cord-010119-t1x9gknd 5456 27 percent percent NN cord-010119-t1x9gknd 5456 28 of of IN cord-010119-t1x9gknd 5456 29 coolers cooler NNS cord-010119-t1x9gknd 5456 30 fully fully RB cord-010119-t1x9gknd 5456 31 used use VBN cord-010119-t1x9gknd 5456 32 . . . cord-010119-t1x9gknd 5457 1 It -PRON- PRP cord-010119-t1x9gknd 5457 2 also also RB cord-010119-t1x9gknd 5457 3 consumed consume VBD cord-010119-t1x9gknd 5457 4 valuable valuable JJ cord-010119-t1x9gknd 5457 5 staff staff NN cord-010119-t1x9gknd 5457 6 time time NN cord-010119-t1x9gknd 5457 7 as as IN cord-010119-t1x9gknd 5457 8 technologists technologist NNS cord-010119-t1x9gknd 5457 9 typically typically RB cord-010119-t1x9gknd 5457 10 made make VBD cord-010119-t1x9gknd 5457 11 20 20 CD cord-010119-t1x9gknd 5457 12 - - SYM cord-010119-t1x9gknd 5457 13 45 45 CD cord-010119-t1x9gknd 5457 14 trips trip NNS cord-010119-t1x9gknd 5457 15 per per IN cord-010119-t1x9gknd 5457 16 month month NN cord-010119-t1x9gknd 5457 17 from from IN cord-010119-t1x9gknd 5457 18 the the DT cord-010119-t1x9gknd 5457 19 blood blood NN cord-010119-t1x9gknd 5457 20 bank bank NN cord-010119-t1x9gknd 5457 21 to to IN cord-010119-t1x9gknd 5457 22 the the DT cord-010119-t1x9gknd 5457 23 ED ED NNP cord-010119-t1x9gknd 5457 24 . . . cord-010119-t1x9gknd 5458 1 Plus plus CC cord-010119-t1x9gknd 5458 2 , , , cord-010119-t1x9gknd 5458 3 there there EX cord-010119-t1x9gknd 5458 4 was be VBD cord-010119-t1x9gknd 5458 5 no no DT cord-010119-t1x9gknd 5458 6 effective effective JJ cord-010119-t1x9gknd 5458 7 way way NN cord-010119-t1x9gknd 5458 8 to to TO cord-010119-t1x9gknd 5458 9 maintain maintain VB cord-010119-t1x9gknd 5458 10 traceability traceability NN cord-010119-t1x9gknd 5458 11 , , , cord-010119-t1x9gknd 5458 12 control control NN cord-010119-t1x9gknd 5458 13 access access NN cord-010119-t1x9gknd 5458 14 to to IN cord-010119-t1x9gknd 5458 15 coolers cooler NNS cord-010119-t1x9gknd 5458 16 or or CC cord-010119-t1x9gknd 5458 17 monitor monitor VB cord-010119-t1x9gknd 5458 18 usage usage NN cord-010119-t1x9gknd 5458 19 . . . cord-010119-t1x9gknd 5459 1 Results result NNS cord-010119-t1x9gknd 5459 2 / / SYM cord-010119-t1x9gknd 5459 3 Findings finding NNS cord-010119-t1x9gknd 5459 4 : : : cord-010119-t1x9gknd 5460 1 Since since IN cord-010119-t1x9gknd 5460 2 our -PRON- PRP$ cord-010119-t1x9gknd 5460 3 November November NNP cord-010119-t1x9gknd 5460 4 2016 2016 CD cord-010119-t1x9gknd 5460 5 implementation implementation NN cord-010119-t1x9gknd 5460 6 , , , cord-010119-t1x9gknd 5460 7 BloodTrack BloodTrack NNP cord-010119-t1x9gknd 5460 8 Emerge Emerge NNP cord-010119-t1x9gknd 5460 9 has have VBZ cord-010119-t1x9gknd 5460 10 freed free VBN cord-010119-t1x9gknd 5460 11 up up RP cord-010119-t1x9gknd 5460 12 technologists technologist NNS cord-010119-t1x9gknd 5460 13 to to TO cord-010119-t1x9gknd 5460 14 perform perform VB cord-010119-t1x9gknd 5460 15 important important JJ cord-010119-t1x9gknd 5460 16 tasks task NNS cord-010119-t1x9gknd 5460 17 , , , cord-010119-t1x9gknd 5460 18 tightened tighten VBD cord-010119-t1x9gknd 5460 19 traceability traceability NN cord-010119-t1x9gknd 5460 20 and and CC cord-010119-t1x9gknd 5460 21 inventory inventory NN cord-010119-t1x9gknd 5460 22 control control NN cord-010119-t1x9gknd 5460 23 procedures procedure NNS cord-010119-t1x9gknd 5460 24 and and CC cord-010119-t1x9gknd 5460 25 contributed contribute VBD cord-010119-t1x9gknd 5460 26 to to IN cord-010119-t1x9gknd 5460 27 the the DT cord-010119-t1x9gknd 5460 28 Medical Medical NNP cord-010119-t1x9gknd 5460 29 City City NNP cord-010119-t1x9gknd 5460 30 Plano Plano NNP cord-010119-t1x9gknd 5460 31 's 's POS cord-010119-t1x9gknd 5460 32 verification verification NN cord-010119-t1x9gknd 5460 33 as as IN cord-010119-t1x9gknd 5460 34 a a DT cord-010119-t1x9gknd 5460 35 Level Level NNP cord-010119-t1x9gknd 5460 36 1 1 CD cord-010119-t1x9gknd 5460 37 trauma trauma NN cord-010119-t1x9gknd 5460 38 center center NN cord-010119-t1x9gknd 5460 39 . . . cord-010119-t1x9gknd 5461 1 Rather rather RB cord-010119-t1x9gknd 5461 2 than than IN cord-010119-t1x9gknd 5461 3 preparing prepare VBG cord-010119-t1x9gknd 5461 4 coolers cooler NNS cord-010119-t1x9gknd 5461 5 of of IN cord-010119-t1x9gknd 5461 6 blood blood NN cord-010119-t1x9gknd 5461 7 in in IN cord-010119-t1x9gknd 5461 8 case case NN cord-010119-t1x9gknd 5461 9 they -PRON- PRP cord-010119-t1x9gknd 5461 10 may may MD cord-010119-t1x9gknd 5461 11 be be VB cord-010119-t1x9gknd 5461 12 needed need VBN cord-010119-t1x9gknd 5461 13 in in IN cord-010119-t1x9gknd 5461 14 emergency emergency NN cord-010119-t1x9gknd 5461 15 situations situation NNS cord-010119-t1x9gknd 5461 16 , , , cord-010119-t1x9gknd 5461 17 BloodTrack BloodTrack NNP cord-010119-t1x9gknd 5461 18 Emerge Emerge NNP cord-010119-t1x9gknd 5461 19 provides provide VBZ cord-010119-t1x9gknd 5461 20 ED ED NNP cord-010119-t1x9gknd 5461 21 staff staff NN cord-010119-t1x9gknd 5461 22 ready ready JJ cord-010119-t1x9gknd 5461 23 access access NN cord-010119-t1x9gknd 5461 24 to to IN cord-010119-t1x9gknd 5461 25 emergency emergency NN cord-010119-t1x9gknd 5461 26 units unit NNS cord-010119-t1x9gknd 5461 27 whenever whenever WRB cord-010119-t1x9gknd 5461 28 they -PRON- PRP cord-010119-t1x9gknd 5461 29 're be VBP cord-010119-t1x9gknd 5461 30 actually actually RB cord-010119-t1x9gknd 5461 31 needed need VBN cord-010119-t1x9gknd 5461 32 -and -and VBD cord-010119-t1x9gknd 5461 33 frees free NNS cord-010119-t1x9gknd 5461 34 up up RP cord-010119-t1x9gknd 5461 35 an an DT cord-010119-t1x9gknd 5461 36 estimated estimate VBN cord-010119-t1x9gknd 5461 37 6 6 CD cord-010119-t1x9gknd 5461 38 - - SYM cord-010119-t1x9gknd 5461 39 10 10 CD cord-010119-t1x9gknd 5461 40 hours hour NNS cord-010119-t1x9gknd 5461 41 of of IN cord-010119-t1x9gknd 5461 42 tech tech NN cord-010119-t1x9gknd 5461 43 time time NN cord-010119-t1x9gknd 5461 44 per per IN cord-010119-t1x9gknd 5461 45 month month NN cord-010119-t1x9gknd 5461 46 during during IN cord-010119-t1x9gknd 5461 47 which which WDT cord-010119-t1x9gknd 5461 48 they -PRON- PRP cord-010119-t1x9gknd 5461 49 can can MD cord-010119-t1x9gknd 5461 50 perform perform VB cord-010119-t1x9gknd 5461 51 other other JJ cord-010119-t1x9gknd 5461 52 tasks task NNS cord-010119-t1x9gknd 5461 53 . . . cord-010119-t1x9gknd 5462 1 Audio audio JJ cord-010119-t1x9gknd 5462 2 and and CC cord-010119-t1x9gknd 5462 3 visual visual JJ cord-010119-t1x9gknd 5462 4 alerts alert NNS cord-010119-t1x9gknd 5462 5 notify notify VBP cord-010119-t1x9gknd 5462 6 the the DT cord-010119-t1x9gknd 5462 7 blood blood NN cord-010119-t1x9gknd 5462 8 bank bank NN cord-010119-t1x9gknd 5462 9 when when WRB cord-010119-t1x9gknd 5462 10 emergency emergency NN cord-010119-t1x9gknd 5462 11 units unit NNS cord-010119-t1x9gknd 5462 12 are be VBP cord-010119-t1x9gknd 5462 13 removed remove VBN cord-010119-t1x9gknd 5462 14 , , , cord-010119-t1x9gknd 5462 15 allowing allow VBG cord-010119-t1x9gknd 5462 16 a a DT cord-010119-t1x9gknd 5462 17 quick quick JJ cord-010119-t1x9gknd 5462 18 response response NN cord-010119-t1x9gknd 5462 19 . . . cord-010119-t1x9gknd 5463 1 Plus plus CC cord-010119-t1x9gknd 5463 2 , , , cord-010119-t1x9gknd 5463 3 by by IN cord-010119-t1x9gknd 5463 4 stocking stock VBG cord-010119-t1x9gknd 5463 5 emergency emergency NN cord-010119-t1x9gknd 5463 6 blood blood NN cord-010119-t1x9gknd 5463 7 supplies supply NNS cord-010119-t1x9gknd 5463 8 in in IN cord-010119-t1x9gknd 5463 9 the the DT cord-010119-t1x9gknd 5463 10 ED ED NNP cord-010119-t1x9gknd 5463 11 , , , cord-010119-t1x9gknd 5463 12 the the DT cord-010119-t1x9gknd 5463 13 blood blood NN cord-010119-t1x9gknd 5463 14 bank bank NN cord-010119-t1x9gknd 5463 15 is be VBZ cord-010119-t1x9gknd 5463 16 n't not RB cord-010119-t1x9gknd 5463 17 unnecessarily unnecessarily RB cord-010119-t1x9gknd 5463 18 tying tie VBG cord-010119-t1x9gknd 5463 19 up up RP cord-010119-t1x9gknd 5463 20 group group NN cord-010119-t1x9gknd 5463 21 O O NNP cord-010119-t1x9gknd 5463 22 RBC RBC NNP cord-010119-t1x9gknd 5463 23 units unit NNS cord-010119-t1x9gknd 5463 24 . . . cord-010119-t1x9gknd 5464 1 Today today NN cord-010119-t1x9gknd 5464 2 , , , cord-010119-t1x9gknd 5464 3 the the DT cord-010119-t1x9gknd 5464 4 blood blood NN cord-010119-t1x9gknd 5464 5 bank bank NN cord-010119-t1x9gknd 5464 6 stocks stock NNS cord-010119-t1x9gknd 5464 7 and and CC cord-010119-t1x9gknd 5464 8 maintains maintain VBZ cord-010119-t1x9gknd 5464 9 2 2 CD cord-010119-t1x9gknd 5464 10 - - SYM cord-010119-t1x9gknd 5464 11 4 4 CD cord-010119-t1x9gknd 5464 12 units unit NNS cord-010119-t1x9gknd 5464 13 of of IN cord-010119-t1x9gknd 5464 14 group group NN cord-010119-t1x9gknd 5464 15 O o NN cord-010119-t1x9gknd 5464 16 RhD rhd NN cord-010119-t1x9gknd 5464 17 negative negative JJ cord-010119-t1x9gknd 5464 18 , , , cord-010119-t1x9gknd 5464 19 4 4 CD cord-010119-t1x9gknd 5464 20 units unit NNS cord-010119-t1x9gknd 5464 21 of of IN cord-010119-t1x9gknd 5464 22 O o NN cord-010119-t1x9gknd 5464 23 RhD rhd NN cord-010119-t1x9gknd 5464 24 positive positive JJ cord-010119-t1x9gknd 5464 25 , , , cord-010119-t1x9gknd 5464 26 and and CC cord-010119-t1x9gknd 5464 27 4 4 CD cord-010119-t1x9gknd 5464 28 units unit NNS cord-010119-t1x9gknd 5464 29 of of IN cord-010119-t1x9gknd 5464 30 group group NN cord-010119-t1x9gknd 5464 31 A A NNP cord-010119-t1x9gknd 5464 32 thawed thaw VBD cord-010119-t1x9gknd 5464 33 plasma/ plasma/ VBZ cord-010119-t1x9gknd 5464 34 liquid liquid JJ cord-010119-t1x9gknd 5464 35 plasma plasma NN cord-010119-t1x9gknd 5464 36 in in IN cord-010119-t1x9gknd 5464 37 BloodTrack BloodTrack NNP cord-010119-t1x9gknd 5464 38 Emerge Emerge NNP cord-010119-t1x9gknd 5464 39 . . . cord-010119-t1x9gknd 5465 1 Conclusion conclusion NN cord-010119-t1x9gknd 5465 2 : : : cord-010119-t1x9gknd 5466 1 Implementing implement VBG cord-010119-t1x9gknd 5466 2 BloodTrack BloodTrack NNP cord-010119-t1x9gknd 5466 3 Emerge Emerge NNP cord-010119-t1x9gknd 5466 4 has have VBZ cord-010119-t1x9gknd 5466 5 enabled enable VBN cord-010119-t1x9gknd 5466 6 us -PRON- PRP cord-010119-t1x9gknd 5466 7 to to TO cord-010119-t1x9gknd 5466 8 more more RBR cord-010119-t1x9gknd 5466 9 effectively effectively RB cord-010119-t1x9gknd 5466 10 provide provide VB cord-010119-t1x9gknd 5466 11 blood blood NN cord-010119-t1x9gknd 5466 12 products product NNS cord-010119-t1x9gknd 5466 13 for for IN cord-010119-t1x9gknd 5466 14 incoming incoming JJ cord-010119-t1x9gknd 5466 15 trauma trauma NN cord-010119-t1x9gknd 5466 16 patients patient NNS cord-010119-t1x9gknd 5466 17 to to TO cord-010119-t1x9gknd 5466 18 support support VB cord-010119-t1x9gknd 5466 19 ratio ratio NN cord-010119-t1x9gknd 5466 20 - - HYPH cord-010119-t1x9gknd 5466 21 based base VBN cord-010119-t1x9gknd 5466 22 transfusions transfusion NNS cord-010119-t1x9gknd 5466 23 , , , cord-010119-t1x9gknd 5466 24 improve improve VB cord-010119-t1x9gknd 5466 25 staff staff NN cord-010119-t1x9gknd 5466 26 efficiencies efficiency NNS cord-010119-t1x9gknd 5466 27 and and CC cord-010119-t1x9gknd 5466 28 proactively proactively RB cord-010119-t1x9gknd 5466 29 respond respond VB cord-010119-t1x9gknd 5466 30 to to IN cord-010119-t1x9gknd 5466 31 emergency emergency NN cord-010119-t1x9gknd 5466 32 situations situation NNS cord-010119-t1x9gknd 5466 33 . . . cord-010119-t1x9gknd 5467 1 Background Background NNP cord-010119-t1x9gknd 5467 2 / / SYM cord-010119-t1x9gknd 5467 3 Case Case NNP cord-010119-t1x9gknd 5467 4 Studies Studies NNPS cord-010119-t1x9gknd 5468 1 : : : cord-010119-t1x9gknd 5468 2 Platelets platelet NNS cord-010119-t1x9gknd 5468 3 are be VBP cord-010119-t1x9gknd 5468 4 a a DT cord-010119-t1x9gknd 5468 5 limited limited JJ cord-010119-t1x9gknd 5468 6 resource resource NN cord-010119-t1x9gknd 5468 7 for for IN cord-010119-t1x9gknd 5468 8 which which WDT cord-010119-t1x9gknd 5468 9 the the DT cord-010119-t1x9gknd 5468 10 benefits benefit NNS cord-010119-t1x9gknd 5468 11 of of IN cord-010119-t1x9gknd 5468 12 transfusion transfusion NN cord-010119-t1x9gknd 5468 13 must must MD cord-010119-t1x9gknd 5468 14 be be VB cord-010119-t1x9gknd 5468 15 weighed weigh VBN cord-010119-t1x9gknd 5468 16 against against IN cord-010119-t1x9gknd 5468 17 the the DT cord-010119-t1x9gknd 5468 18 risks risk NNS cord-010119-t1x9gknd 5468 19 . . . cord-010119-t1x9gknd 5469 1 In in IN cord-010119-t1x9gknd 5469 2 2015 2015 CD cord-010119-t1x9gknd 5469 3 , , , cord-010119-t1x9gknd 5469 4 the the DT cord-010119-t1x9gknd 5469 5 AABB AABB NNP cord-010119-t1x9gknd 5469 6 published publish VBN cord-010119-t1x9gknd 5469 7 platelet platelet NN cord-010119-t1x9gknd 5469 8 transfusion transfusion NN cord-010119-t1x9gknd 5469 9 guidelines guideline NNS cord-010119-t1x9gknd 5469 10 to to TO cord-010119-t1x9gknd 5469 11 assist assist VB cord-010119-t1x9gknd 5469 12 providers provider NNS cord-010119-t1x9gknd 5469 13 . . . cord-010119-t1x9gknd 5470 1 At at IN cord-010119-t1x9gknd 5470 2 our -PRON- PRP$ cord-010119-t1x9gknd 5470 3 academic academic JJ cord-010119-t1x9gknd 5470 4 medical medical JJ cord-010119-t1x9gknd 5470 5 center center NN cord-010119-t1x9gknd 5470 6 , , , cord-010119-t1x9gknd 5470 7 a a DT cord-010119-t1x9gknd 5470 8 computer computer NN cord-010119-t1x9gknd 5470 9 provider provider NN cord-010119-t1x9gknd 5470 10 order order NN cord-010119-t1x9gknd 5470 11 entry entry NN cord-010119-t1x9gknd 5470 12 ( ( -LRB- cord-010119-t1x9gknd 5470 13 CPOE CPOE NNP cord-010119-t1x9gknd 5470 14 ) ) -RRB- cord-010119-t1x9gknd 5470 15 system system NN cord-010119-t1x9gknd 5470 16 combines combine VBZ cord-010119-t1x9gknd 5470 17 institutional institutional JJ cord-010119-t1x9gknd 5470 18 transfusion transfusion NN cord-010119-t1x9gknd 5470 19 guidelines guideline NNS cord-010119-t1x9gknd 5470 20 with with IN cord-010119-t1x9gknd 5470 21 a a DT cord-010119-t1x9gknd 5470 22 patient patient NN cord-010119-t1x9gknd 5470 23 's 's POS cord-010119-t1x9gknd 5470 24 most most RBS cord-010119-t1x9gknd 5470 25 recent recent JJ cord-010119-t1x9gknd 5470 26 lab lab NN cord-010119-t1x9gknd 5470 27 results result NNS cord-010119-t1x9gknd 5470 28 to to TO cord-010119-t1x9gknd 5470 29 guide guide VB cord-010119-t1x9gknd 5470 30 transfusion transfusion NN cord-010119-t1x9gknd 5470 31 decisions decision NNS cord-010119-t1x9gknd 5470 32 . . . cord-010119-t1x9gknd 5471 1 Discordant discordant JJ cord-010119-t1x9gknd 5471 2 information information NN cord-010119-t1x9gknd 5471 3 activates activate VBZ cord-010119-t1x9gknd 5471 4 an an DT cord-010119-t1x9gknd 5471 5 " " `` cord-010119-t1x9gknd 5471 6 override override NN cord-010119-t1x9gknd 5471 7 " " '' cord-010119-t1x9gknd 5471 8 system system NN cord-010119-t1x9gknd 5471 9 , , , cord-010119-t1x9gknd 5471 10 in in IN cord-010119-t1x9gknd 5471 11 which which WDT cord-010119-t1x9gknd 5471 12 providers provider NNS cord-010119-t1x9gknd 5471 13 are be VBP cord-010119-t1x9gknd 5471 14 prompted prompt VBN cord-010119-t1x9gknd 5471 15 to to TO cord-010119-t1x9gknd 5471 16 select select VB cord-010119-t1x9gknd 5471 17 a a DT cord-010119-t1x9gknd 5471 18 prefixed prefixed JJ cord-010119-t1x9gknd 5471 19 indication indication NN cord-010119-t1x9gknd 5471 20 for for IN cord-010119-t1x9gknd 5471 21 transfusion transfusion NN cord-010119-t1x9gknd 5471 22 ( ( -LRB- cord-010119-t1x9gknd 5471 23 e.g. e.g. RB cord-010119-t1x9gknd 5471 24 Count count NN cord-010119-t1x9gknd 5471 25 < < XX cord-010119-t1x9gknd 5472 1 10 10 CD cord-010119-t1x9gknd 5472 2 K k NN cord-010119-t1x9gknd 5472 3 / / SYM cord-010119-t1x9gknd 5472 4 ml ml XX cord-010119-t1x9gknd 5472 5 [ [ -LRB- cord-010119-t1x9gknd 5472 6 prophylaxis prophylaxis NN cord-010119-t1x9gknd 5472 7 ] ] -RRB- cord-010119-t1x9gknd 5472 8 ) ) -RRB- cord-010119-t1x9gknd 5473 1 with with IN cord-010119-t1x9gknd 5473 2 the the DT cord-010119-t1x9gknd 5473 3 option option NN cord-010119-t1x9gknd 5473 4 to to TO cord-010119-t1x9gknd 5473 5 add add VB cord-010119-t1x9gknd 5473 6 a a DT cord-010119-t1x9gknd 5473 7 free free JJ cord-010119-t1x9gknd 5473 8 - - HYPH cord-010119-t1x9gknd 5473 9 text text NN cord-010119-t1x9gknd 5473 10 comment comment NN cord-010119-t1x9gknd 5473 11 . . . cord-010119-t1x9gknd 5474 1 The the DT cord-010119-t1x9gknd 5474 2 order order NN cord-010119-t1x9gknd 5474 3 is be VBZ cord-010119-t1x9gknd 5474 4 placed place VBN cord-010119-t1x9gknd 5474 5 and and CC cord-010119-t1x9gknd 5474 6 data data NN cord-010119-t1x9gknd 5474 7 is be VBZ cord-010119-t1x9gknd 5474 8 stored store VBN cord-010119-t1x9gknd 5474 9 for for IN cord-010119-t1x9gknd 5474 10 later later JJ cord-010119-t1x9gknd 5474 11 review review NN cord-010119-t1x9gknd 5474 12 . . . cord-010119-t1x9gknd 5475 1 Study Study NNP cord-010119-t1x9gknd 5475 2 Design Design NNP cord-010119-t1x9gknd 5475 3 / / SYM cord-010119-t1x9gknd 5475 4 Method method NN cord-010119-t1x9gknd 5475 5 : : : cord-010119-t1x9gknd 5475 6 Override override VB cord-010119-t1x9gknd 5475 7 platelet platelet NN cord-010119-t1x9gknd 5475 8 orders order NNS cord-010119-t1x9gknd 5475 9 placed place VBN cord-010119-t1x9gknd 5475 10 from from IN cord-010119-t1x9gknd 5475 11 June June NNP cord-010119-t1x9gknd 5475 12 2015-October 2015-october CD cord-010119-t1x9gknd 5475 13 2016 2016 CD cord-010119-t1x9gknd 5475 14 were be VBD cord-010119-t1x9gknd 5475 15 reviewed review VBN cord-010119-t1x9gknd 5475 16 using use VBG cord-010119-t1x9gknd 5475 17 the the DT cord-010119-t1x9gknd 5475 18 following follow VBG cord-010119-t1x9gknd 5475 19 data datum NNS cord-010119-t1x9gknd 5475 20 : : : cord-010119-t1x9gknd 5475 21 prefixed prefix VBN cord-010119-t1x9gknd 5475 22 indication indication NN cord-010119-t1x9gknd 5475 23 , , , cord-010119-t1x9gknd 5475 24 most most JJS cord-010119-t1x9gknd 5475 25 recent recent JJ cord-010119-t1x9gknd 5475 26 platelet platelet NN cord-010119-t1x9gknd 5475 27 count count NN cord-010119-t1x9gknd 5475 28 , , , cord-010119-t1x9gknd 5475 29 free free JJ cord-010119-t1x9gknd 5475 30 - - HYPH cord-010119-t1x9gknd 5475 31 text text NN cord-010119-t1x9gknd 5475 32 comment comment NN cord-010119-t1x9gknd 5475 33 , , , cord-010119-t1x9gknd 5475 34 and and CC cord-010119-t1x9gknd 5475 35 ordering order VBG cord-010119-t1x9gknd 5475 36 service service NN cord-010119-t1x9gknd 5475 37 / / SYM cord-010119-t1x9gknd 5475 38 department department NN cord-010119-t1x9gknd 5475 39 . . . cord-010119-t1x9gknd 5476 1 One one CD cord-010119-t1x9gknd 5476 2 of of IN cord-010119-t1x9gknd 5476 3 five five CD cord-010119-t1x9gknd 5476 4 " " `` cord-010119-t1x9gknd 5476 5 codes code NNS cord-010119-t1x9gknd 5476 6 " " '' cord-010119-t1x9gknd 5476 7 was be VBD cord-010119-t1x9gknd 5476 8 assigned assign VBN cord-010119-t1x9gknd 5476 9 to to IN cord-010119-t1x9gknd 5476 10 each each DT cord-010119-t1x9gknd 5476 11 order order NN cord-010119-t1x9gknd 5476 12 : : : cord-010119-t1x9gknd 5477 1 I -PRON- PRP cord-010119-t1x9gknd 5477 2 - - HYPH cord-010119-t1x9gknd 5477 3 Indicated indicate VBN cord-010119-t1x9gknd 5477 4 or or CC cord-010119-t1x9gknd 5477 5 NI NI NNP cord-010119-t1x9gknd 5478 1 -Not -Not NNP cord-010119-t1x9gknd 5478 2 indicated indicate VBN cord-010119-t1x9gknd 5478 3 ( ( -LRB- cord-010119-t1x9gknd 5478 4 based base VBN cord-010119-t1x9gknd 5478 5 on on IN cord-010119-t1x9gknd 5478 6 institutional institutional JJ cord-010119-t1x9gknd 5478 7 / / SYM cord-010119-t1x9gknd 5478 8 AABB AABB NNP cord-010119-t1x9gknd 5478 9 guidelines guideline NNS cord-010119-t1x9gknd 5478 10 ) ) -RRB- cord-010119-t1x9gknd 5478 11 ; ; : cord-010119-t1x9gknd 5478 12 NMI nmi NN cord-010119-t1x9gknd 5478 13 - - HYPH cord-010119-t1x9gknd 5478 14 Need need VB cord-010119-t1x9gknd 5478 15 more more JJR cord-010119-t1x9gknd 5478 16 information information NN cord-010119-t1x9gknd 5478 17 ; ; : cord-010119-t1x9gknd 5478 18 P p NN cord-010119-t1x9gknd 5478 19 - - HYPH cord-010119-t1x9gknd 5478 20 Protocol Protocol NNP cord-010119-t1x9gknd 5478 21 ( ( -LRB- cord-010119-t1x9gknd 5478 22 e.g. e.g. IN cord-010119-t1x9gknd 5478 23 liver liver NN cord-010119-t1x9gknd 5478 24 transplant transplant NN cord-010119-t1x9gknd 5478 25 ) ) -RRB- cord-010119-t1x9gknd 5478 26 , , , cord-010119-t1x9gknd 5478 27 and and CC cord-010119-t1x9gknd 5478 28 NIC NIC NNP cord-010119-t1x9gknd 5478 29 - - HYPH cord-010119-t1x9gknd 5478 30 Non Non NNP cord-010119-t1x9gknd 5478 31 - - NN cord-010119-t1x9gknd 5478 32 indication indication NN cord-010119-t1x9gknd 5478 33 comments comment NNS cord-010119-t1x9gknd 5478 34 ( ( -LRB- cord-010119-t1x9gknd 5478 35 e.g. e.g. IN cord-010119-t1x9gknd 5478 36 reserve reserve NN cord-010119-t1x9gknd 5478 37 for for IN cord-010119-t1x9gknd 5478 38 OR OR NNP cord-010119-t1x9gknd 5478 39 ) ) -RRB- cord-010119-t1x9gknd 5478 40 . . . cord-010119-t1x9gknd 5479 1 Free free JJ cord-010119-t1x9gknd 5479 2 - - HYPH cord-010119-t1x9gknd 5479 3 text text NN cord-010119-t1x9gknd 5479 4 comments comment NNS cord-010119-t1x9gknd 5479 5 were be VBD cord-010119-t1x9gknd 5479 6 categorized categorize VBN cord-010119-t1x9gknd 5479 7 and and CC cord-010119-t1x9gknd 5479 8 assigned assign VBN cord-010119-t1x9gknd 5479 9 one one CD cord-010119-t1x9gknd 5479 10 or or CC cord-010119-t1x9gknd 5479 11 more more JJR cord-010119-t1x9gknd 5479 12 keywords keyword NNS cord-010119-t1x9gknd 5479 13 in in IN cord-010119-t1x9gknd 5479 14 order order NN cord-010119-t1x9gknd 5479 15 to to TO cord-010119-t1x9gknd 5479 16 determine determine VB cord-010119-t1x9gknd 5479 17 the the DT cord-010119-t1x9gknd 5479 18 common common JJ cord-010119-t1x9gknd 5479 19 reasons reason NNS cord-010119-t1x9gknd 5479 20 for for IN cord-010119-t1x9gknd 5479 21 overrides override NNS cord-010119-t1x9gknd 5479 22 . . . cord-010119-t1x9gknd 5480 1 Results result NNS cord-010119-t1x9gknd 5480 2 / / SYM cord-010119-t1x9gknd 5480 3 Finding finding NN cord-010119-t1x9gknd 5480 4 : : : cord-010119-t1x9gknd 5480 5 Over over IN cord-010119-t1x9gknd 5480 6 a a DT cord-010119-t1x9gknd 5480 7 17-month 17-month JJ cord-010119-t1x9gknd 5480 8 period period NN cord-010119-t1x9gknd 5480 9 , , , cord-010119-t1x9gknd 5480 10 1,270 1,270 CD cord-010119-t1x9gknd 5480 11 CPOE CPOE NNP cord-010119-t1x9gknd 5480 12 override override VBP cord-010119-t1x9gknd 5480 13 platelet platelet NN cord-010119-t1x9gknd 5480 14 orders order NNS cord-010119-t1x9gknd 5480 15 occurred occur VBD cord-010119-t1x9gknd 5480 16 . . . cord-010119-t1x9gknd 5481 1 The the DT cord-010119-t1x9gknd 5481 2 percentages percentage NNS cord-010119-t1x9gknd 5481 3 of of IN cord-010119-t1x9gknd 5481 4 code code NN cord-010119-t1x9gknd 5481 5 assignments assignment NNS cord-010119-t1x9gknd 5481 6 by by IN cord-010119-t1x9gknd 5481 7 month month NN cord-010119-t1x9gknd 5481 8 are be VBP cord-010119-t1x9gknd 5481 9 provided provide VBN cord-010119-t1x9gknd 5481 10 in in IN cord-010119-t1x9gknd 5481 11 Table Table NNP cord-010119-t1x9gknd 5481 12 01 01 CD cord-010119-t1x9gknd 5481 13 below below RB cord-010119-t1x9gknd 5481 14 . . . cord-010119-t1x9gknd 5482 1 Overall overall RB cord-010119-t1x9gknd 5482 2 , , , cord-010119-t1x9gknd 5482 3 532 532 CD cord-010119-t1x9gknd 5482 4 ( ( -LRB- cord-010119-t1x9gknd 5482 5 42 42 CD cord-010119-t1x9gknd 5482 6 % % NN cord-010119-t1x9gknd 5482 7 ) ) -RRB- cord-010119-t1x9gknd 5482 8 were be VBD cord-010119-t1x9gknd 5482 9 assigned assign VBN cord-010119-t1x9gknd 5482 10 as as IN cord-010119-t1x9gknd 5482 11 not not RB cord-010119-t1x9gknd 5482 12 indicated indicate VBN cord-010119-t1x9gknd 5482 13 ( ( -LRB- cord-010119-t1x9gknd 5482 14 NI NI NNP cord-010119-t1x9gknd 5482 15 ) ) -RRB- cord-010119-t1x9gknd 5482 16 . . . cord-010119-t1x9gknd 5483 1 The the DT cord-010119-t1x9gknd 5483 2 top top JJ cord-010119-t1x9gknd 5483 3 keywords keyword NNS cord-010119-t1x9gknd 5483 4 assigned assign VBN cord-010119-t1x9gknd 5483 5 to to IN cord-010119-t1x9gknd 5483 6 free free JJ cord-010119-t1x9gknd 5483 7 - - HYPH cord-010119-t1x9gknd 5483 8 text text NN cord-010119-t1x9gknd 5483 9 comments comment NNS cord-010119-t1x9gknd 5483 10 were be VBD cord-010119-t1x9gknd 5483 11 " " `` cord-010119-t1x9gknd 5483 12 platelet platelet NN cord-010119-t1x9gknd 5483 13 count count NN cord-010119-t1x9gknd 5483 14 less less JJR cord-010119-t1x9gknd 5483 15 than than IN cord-010119-t1x9gknd 5483 16 . . . cord-010119-t1x9gknd 5483 17 . . . cord-010119-t1x9gknd 5483 18 . . . cord-010119-t1x9gknd 5483 19 " " '' cord-010119-t1x9gknd 5484 1 ( ( -LRB- cord-010119-t1x9gknd 5484 2 325 325 CD cord-010119-t1x9gknd 5484 3 ) ) -RRB- cord-010119-t1x9gknd 5484 4 , , , cord-010119-t1x9gknd 5484 5 " " `` cord-010119-t1x9gknd 5484 6 active active JJ cord-010119-t1x9gknd 5484 7 bleeding bleeding NN cord-010119-t1x9gknd 5484 8 " " '' cord-010119-t1x9gknd 5484 9 ( ( -LRB- cord-010119-t1x9gknd 5484 10 303 303 CD cord-010119-t1x9gknd 5484 11 ) ) -RRB- cord-010119-t1x9gknd 5484 12 , , , cord-010119-t1x9gknd 5484 13 " " `` cord-010119-t1x9gknd 5484 14 platelet platelet NN cord-010119-t1x9gknd 5484 15 count count NN cord-010119-t1x9gknd 5484 16 of of IN cord-010119-t1x9gknd 5484 17 . . . cord-010119-t1x9gknd 5484 18 . . . cord-010119-t1x9gknd 5484 19 . . . cord-010119-t1x9gknd 5484 20 " " '' cord-010119-t1x9gknd 5485 1 ( ( -LRB- cord-010119-t1x9gknd 5485 2 173 173 CD cord-010119-t1x9gknd 5485 3 ) ) -RRB- cord-010119-t1x9gknd 5485 4 , , , cord-010119-t1x9gknd 5485 5 and and CC cord-010119-t1x9gknd 5485 6 " " `` cord-010119-t1x9gknd 5485 7 downtrend downtrend NN cord-010119-t1x9gknd 5485 8 " " '' cord-010119-t1x9gknd 5485 9 ( ( -LRB- cord-010119-t1x9gknd 5485 10 92 92 CD cord-010119-t1x9gknd 5485 11 ) ) -RRB- cord-010119-t1x9gknd 5485 12 , , , cord-010119-t1x9gknd 5485 13 many many JJ cord-010119-t1x9gknd 5485 14 with with IN cord-010119-t1x9gknd 5485 15 specified specified JJ cord-010119-t1x9gknd 5485 16 platelet platelet NN cord-010119-t1x9gknd 5485 17 count count NN cord-010119-t1x9gknd 5485 18 goals goal NNS cord-010119-t1x9gknd 5485 19 . . . cord-010119-t1x9gknd 5486 1 Certain certain JJ cord-010119-t1x9gknd 5486 2 platelet platelet NN cord-010119-t1x9gknd 5486 3 count count NN cord-010119-t1x9gknd 5486 4 goals goal NNS cord-010119-t1x9gknd 5486 5 and and CC cord-010119-t1x9gknd 5486 6 reasons reason NNS cord-010119-t1x9gknd 5486 7 for for IN cord-010119-t1x9gknd 5486 8 transfusion transfusion NN cord-010119-t1x9gknd 5486 9 ( ( -LRB- cord-010119-t1x9gknd 5486 10 e.g. e.g. RB cord-010119-t1x9gknd 5486 11 " " `` cord-010119-t1x9gknd 5486 12 downtrend downtrend NN cord-010119-t1x9gknd 5486 13 , , , cord-010119-t1x9gknd 5486 14 " " '' cord-010119-t1x9gknd 5486 15 " " `` cord-010119-t1x9gknd 5486 16 anticipate anticipate VBP cord-010119-t1x9gknd 5486 17 drop drop NN cord-010119-t1x9gknd 5486 18 , , , cord-010119-t1x9gknd 5486 19 " " '' cord-010119-t1x9gknd 5486 20 or or CC cord-010119-t1x9gknd 5486 21 " " `` cord-010119-t1x9gknd 5486 22 per per IN cord-010119-t1x9gknd 5486 23 service service NN cord-010119-t1x9gknd 5486 24 , , , cord-010119-t1x9gknd 5486 25 " " '' cord-010119-t1x9gknd 5486 26 ) ) -RRB- cord-010119-t1x9gknd 5486 27 are be VBP cord-010119-t1x9gknd 5486 28 not not RB cord-010119-t1x9gknd 5486 29 included include VBN cord-010119-t1x9gknd 5486 30 in in IN cord-010119-t1x9gknd 5486 31 institutional institutional JJ cord-010119-t1x9gknd 5486 32 or or CC cord-010119-t1x9gknd 5486 33 AABB AABB NNP cord-010119-t1x9gknd 5486 34 guidelines guideline NNS cord-010119-t1x9gknd 5486 35 . . . cord-010119-t1x9gknd 5487 1 Of of IN cord-010119-t1x9gknd 5487 2 note note NN cord-010119-t1x9gknd 5487 3 , , , cord-010119-t1x9gknd 5487 4 618 618 CD cord-010119-t1x9gknd 5487 5 ( ( -LRB- cord-010119-t1x9gknd 5487 6 49 49 CD cord-010119-t1x9gknd 5487 7 % % NN cord-010119-t1x9gknd 5487 8 ) ) -RRB- cord-010119-t1x9gknd 5487 9 of of IN cord-010119-t1x9gknd 5487 10 overrides override NNS cord-010119-t1x9gknd 5487 11 were be VBD cord-010119-t1x9gknd 5487 12 placed place VBN cord-010119-t1x9gknd 5487 13 by by IN cord-010119-t1x9gknd 5487 14 Hematology Hematology NNP cord-010119-t1x9gknd 5487 15 - - HYPH cord-010119-t1x9gknd 5487 16 Oncology Oncology NNP cord-010119-t1x9gknd 5487 17 providers provider NNS cord-010119-t1x9gknd 5487 18 . . . cord-010119-t1x9gknd 5488 1 Conclusion conclusion NN cord-010119-t1x9gknd 5488 2 : : : cord-010119-t1x9gknd 5489 1 A a DT cord-010119-t1x9gknd 5489 2 majority majority NN cord-010119-t1x9gknd 5489 3 of of IN cord-010119-t1x9gknd 5489 4 override override NN cord-010119-t1x9gknd 5489 5 platelet platelet NN cord-010119-t1x9gknd 5489 6 orders order NNS cord-010119-t1x9gknd 5489 7 were be VBD cord-010119-t1x9gknd 5489 8 determined determine VBN cord-010119-t1x9gknd 5489 9 to to TO cord-010119-t1x9gknd 5489 10 not not RB cord-010119-t1x9gknd 5489 11 be be VB cord-010119-t1x9gknd 5489 12 indicated indicate VBN cord-010119-t1x9gknd 5489 13 based base VBN cord-010119-t1x9gknd 5489 14 on on IN cord-010119-t1x9gknd 5489 15 institutional institutional JJ cord-010119-t1x9gknd 5489 16 and and CC cord-010119-t1x9gknd 5489 17 AABB AABB NNP cord-010119-t1x9gknd 5489 18 guidelines guideline NNS cord-010119-t1x9gknd 5489 19 . . . cord-010119-t1x9gknd 5490 1 Of of IN cord-010119-t1x9gknd 5490 2 concern concern NN cord-010119-t1x9gknd 5490 3 were be VBD cord-010119-t1x9gknd 5490 4 keywords keyword NNS cord-010119-t1x9gknd 5490 5 such such JJ cord-010119-t1x9gknd 5490 6 as as IN cord-010119-t1x9gknd 5490 7 " " `` cord-010119-t1x9gknd 5490 8 downtrend downtrend NN cord-010119-t1x9gknd 5490 9 " " '' cord-010119-t1x9gknd 5490 10 and and CC cord-010119-t1x9gknd 5490 11 " " `` cord-010119-t1x9gknd 5490 12 anticipate anticipate VB cord-010119-t1x9gknd 5490 13 drop drop NN cord-010119-t1x9gknd 5490 14 , , , cord-010119-t1x9gknd 5490 15 " " '' cord-010119-t1x9gknd 5490 16 as as IN cord-010119-t1x9gknd 5490 17 these these DT cord-010119-t1x9gknd 5490 18 are be VBP cord-010119-t1x9gknd 5490 19 not not RB cord-010119-t1x9gknd 5490 20 indications indication NNS cord-010119-t1x9gknd 5490 21 for for IN cord-010119-t1x9gknd 5490 22 transfusion transfusion NN cord-010119-t1x9gknd 5490 23 and and CC cord-010119-t1x9gknd 5490 24 expose expose VB cord-010119-t1x9gknd 5490 25 patients patient NNS cord-010119-t1x9gknd 5490 26 to to IN cord-010119-t1x9gknd 5490 27 unnecessary unnecessary JJ cord-010119-t1x9gknd 5490 28 transfusions transfusion NNS cord-010119-t1x9gknd 5490 29 . . . cord-010119-t1x9gknd 5491 1 It -PRON- PRP cord-010119-t1x9gknd 5491 2 is be VBZ cord-010119-t1x9gknd 5491 3 unclear unclear JJ cord-010119-t1x9gknd 5491 4 whether whether IN cord-010119-t1x9gknd 5491 5 trainee trainee NN cord-010119-t1x9gknd 5491 6 progression progression NN cord-010119-t1x9gknd 5491 7 throughout throughout IN cord-010119-t1x9gknd 5491 8 the the DT cord-010119-t1x9gknd 5491 9 year year NN cord-010119-t1x9gknd 5491 10 had have VBD cord-010119-t1x9gknd 5491 11 any any DT cord-010119-t1x9gknd 5491 12 effects effect NNS cord-010119-t1x9gknd 5491 13 on on IN cord-010119-t1x9gknd 5491 14 ordering order VBG cord-010119-t1x9gknd 5491 15 practices practice NNS cord-010119-t1x9gknd 5491 16 and and CC cord-010119-t1x9gknd 5491 17 associated associated JJ cord-010119-t1x9gknd 5491 18 override override NN cord-010119-t1x9gknd 5491 19 patterns pattern NNS cord-010119-t1x9gknd 5491 20 . . . cord-010119-t1x9gknd 5492 1 This this DT cord-010119-t1x9gknd 5492 2 review review NN cord-010119-t1x9gknd 5492 3 suggests suggest VBZ cord-010119-t1x9gknd 5492 4 the the DT cord-010119-t1x9gknd 5492 5 potential potential JJ cord-010119-t1x9gknd 5492 6 benefits benefit NNS cord-010119-t1x9gknd 5492 7 of of IN cord-010119-t1x9gknd 5492 8 provider provider NN cord-010119-t1x9gknd 5492 9 education education NN cord-010119-t1x9gknd 5492 10 initiatives initiative NNS cord-010119-t1x9gknd 5492 11 at at IN cord-010119-t1x9gknd 5492 12 all all DT cord-010119-t1x9gknd 5492 13 levels level NNS cord-010119-t1x9gknd 5492 14 of of IN cord-010119-t1x9gknd 5492 15 experience experience NN cord-010119-t1x9gknd 5492 16 ( ( -LRB- cord-010119-t1x9gknd 5492 17 with with IN cord-010119-t1x9gknd 5492 18 particular particular JJ cord-010119-t1x9gknd 5492 19 emphasis emphasis NN cord-010119-t1x9gknd 5492 20 on on IN cord-010119-t1x9gknd 5492 21 Hematology Hematology NNP cord-010119-t1x9gknd 5492 22 - - HYPH cord-010119-t1x9gknd 5492 23 Oncology Oncology NNP cord-010119-t1x9gknd 5492 24 ) ) -RRB- cord-010119-t1x9gknd 5492 25 in in IN cord-010119-t1x9gknd 5492 26 order order NN cord-010119-t1x9gknd 5492 27 to to TO cord-010119-t1x9gknd 5492 28 improve improve VB cord-010119-t1x9gknd 5492 29 blood blood NN cord-010119-t1x9gknd 5492 30 product product NN cord-010119-t1x9gknd 5492 31 utilization utilization NN cord-010119-t1x9gknd 5492 32 practices practice NNS cord-010119-t1x9gknd 5492 33 . . . cord-010119-t1x9gknd 5493 1 Background Background NNP cord-010119-t1x9gknd 5493 2 / / SYM cord-010119-t1x9gknd 5493 3 Case Case NNP cord-010119-t1x9gknd 5493 4 Studies Studies NNPS cord-010119-t1x9gknd 5493 5 : : : cord-010119-t1x9gknd 5494 1 early early JJ cord-010119-t1x9gknd 5494 2 diagnosis diagnosis NN cord-010119-t1x9gknd 5494 3 of of IN cord-010119-t1x9gknd 5494 4 iron iron NN cord-010119-t1x9gknd 5494 5 deficiency deficiency NN cord-010119-t1x9gknd 5494 6 anemia anemia NN cord-010119-t1x9gknd 5494 7 ( ( -LRB- cord-010119-t1x9gknd 5494 8 IDA IDA NNP cord-010119-t1x9gknd 5494 9 ) ) -RRB- cord-010119-t1x9gknd 5494 10 by by IN cord-010119-t1x9gknd 5494 11 clinical clinical JJ cord-010119-t1x9gknd 5494 12 laboratories laboratory NNS cord-010119-t1x9gknd 5494 13 ( ( -LRB- cord-010119-t1x9gknd 5494 14 CL CL NNP cord-010119-t1x9gknd 5494 15 ) ) -RRB- cord-010119-t1x9gknd 5494 16 , , , cord-010119-t1x9gknd 5494 17 with with IN cord-010119-t1x9gknd 5494 18 effective effective JJ cord-010119-t1x9gknd 5494 19 prevention prevention NN cord-010119-t1x9gknd 5494 20 and and CC cord-010119-t1x9gknd 5494 21 treatment treatment NN cord-010119-t1x9gknd 5494 22 in in IN cord-010119-t1x9gknd 5494 23 primary primary JJ cord-010119-t1x9gknd 5494 24 care care NN cord-010119-t1x9gknd 5494 25 may may MD cord-010119-t1x9gknd 5494 26 have have VB cord-010119-t1x9gknd 5494 27 an an DT cord-010119-t1x9gknd 5494 28 impact impact NN cord-010119-t1x9gknd 5494 29 on on IN cord-010119-t1x9gknd 5494 30 packed pack VBN cord-010119-t1x9gknd 5494 31 red red JJ cord-010119-t1x9gknd 5494 32 blood blood NN cord-010119-t1x9gknd 5494 33 cell cell NN cord-010119-t1x9gknd 5494 34 ( ( -LRB- cord-010119-t1x9gknd 5494 35 PRBC PRBC NNP cord-010119-t1x9gknd 5494 36 ) ) -RRB- cord-010119-t1x9gknd 5494 37 transfusion transfusion NN cord-010119-t1x9gknd 5494 38 , , , cord-010119-t1x9gknd 5494 39 as as RB cord-010119-t1x9gknd 5494 40 well well RB cord-010119-t1x9gknd 5494 41 as as IN cord-010119-t1x9gknd 5494 42 intravenous intravenous JJ cord-010119-t1x9gknd 5494 43 iron iron NN cord-010119-t1x9gknd 5494 44 therapy therapy NN cord-010119-t1x9gknd 5494 45 and and CC cord-010119-t1x9gknd 5494 46 , , , cord-010119-t1x9gknd 5494 47 most most RBS cord-010119-t1x9gknd 5494 48 importantly importantly RB cord-010119-t1x9gknd 5494 49 , , , cord-010119-t1x9gknd 5494 50 applying apply VBG cord-010119-t1x9gknd 5494 51 lower low JJR cord-010119-t1x9gknd 5494 52 transfusion transfusion NN cord-010119-t1x9gknd 5494 53 triggers trigger NNS cord-010119-t1x9gknd 5494 54 . . . cord-010119-t1x9gknd 5495 1 They -PRON- PRP cord-010119-t1x9gknd 5495 2 all all DT cord-010119-t1x9gknd 5495 3 help help VBP cord-010119-t1x9gknd 5495 4 to to TO cord-010119-t1x9gknd 5495 5 avoid avoid VB cord-010119-t1x9gknd 5495 6 not not RB cord-010119-t1x9gknd 5495 7 essential essential JJ cord-010119-t1x9gknd 5495 8 transfusions transfusion NNS cord-010119-t1x9gknd 5495 9 , , , cord-010119-t1x9gknd 5495 10 but but CC cord-010119-t1x9gknd 5495 11 also also RB cord-010119-t1x9gknd 5495 12 promote promote VB cord-010119-t1x9gknd 5495 13 health health NN cord-010119-t1x9gknd 5495 14 and and CC cord-010119-t1x9gknd 5495 15 wellbeing wellbeing NN cord-010119-t1x9gknd 5495 16 by by IN cord-010119-t1x9gknd 5495 17 improving improve VBG cord-010119-t1x9gknd 5495 18 iron iron NN cord-010119-t1x9gknd 5495 19 status status NN cord-010119-t1x9gknd 5495 20 in in IN cord-010119-t1x9gknd 5495 21 the the DT cord-010119-t1x9gknd 5495 22 population population NN cord-010119-t1x9gknd 5495 23 . . . cord-010119-t1x9gknd 5496 1 Results result NNS cord-010119-t1x9gknd 5496 2 are be VBP cord-010119-t1x9gknd 5496 3 described describe VBN cord-010119-t1x9gknd 5496 4 after after IN cord-010119-t1x9gknd 5496 5 implementing implement VBG cord-010119-t1x9gknd 5496 6 a a DT cord-010119-t1x9gknd 5496 7 process process NN cord-010119-t1x9gknd 5496 8 to to TO cord-010119-t1x9gknd 5496 9 prevent prevent VB cord-010119-t1x9gknd 5496 10 IDA IDA NNP cord-010119-t1x9gknd 5496 11 , , , cord-010119-t1x9gknd 5496 12 its -PRON- PRP$ cord-010119-t1x9gknd 5496 13 early early JJ cord-010119-t1x9gknd 5496 14 detection detection NN cord-010119-t1x9gknd 5496 15 and and CC cord-010119-t1x9gknd 5496 16 treatment treatment NN cord-010119-t1x9gknd 5496 17 for for IN cord-010119-t1x9gknd 5496 18 years year NNS cord-010119-t1x9gknd 5496 19 2014 2014 CD cord-010119-t1x9gknd 5496 20 - - SYM cord-010119-t1x9gknd 5496 21 2016 2016 CD cord-010119-t1x9gknd 5496 22 . . . cord-010119-t1x9gknd 5497 1 Study Study NNP cord-010119-t1x9gknd 5497 2 Design Design NNP cord-010119-t1x9gknd 5497 3 / / SYM cord-010119-t1x9gknd 5497 4 Methods method NNS cord-010119-t1x9gknd 5497 5 : : : cord-010119-t1x9gknd 5497 6 performance performance NN cord-010119-t1x9gknd 5497 7 measure measure NN cord-010119-t1x9gknd 5497 8 after after IN cord-010119-t1x9gknd 5497 9 educational educational JJ cord-010119-t1x9gknd 5497 10 and and CC cord-010119-t1x9gknd 5497 11 organizational organizational JJ cord-010119-t1x9gknd 5497 12 intervention intervention NN cord-010119-t1x9gknd 5497 13 . . . cord-010119-t1x9gknd 5498 1 Setting setting NN cord-010119-t1x9gknd 5498 2 : : : cord-010119-t1x9gknd 5498 3 public public JJ cord-010119-t1x9gknd 5498 4 integrated integrated JJ cord-010119-t1x9gknd 5498 5 healthcare healthcare NN cord-010119-t1x9gknd 5498 6 system system NN cord-010119-t1x9gknd 5498 7 located locate VBN cord-010119-t1x9gknd 5498 8 in in IN cord-010119-t1x9gknd 5498 9 north north NN cord-010119-t1x9gknd 5498 10 Africa Africa NNP cord-010119-t1x9gknd 5498 11 bordering border VBG cord-010119-t1x9gknd 5498 12 Morocco Morocco NNP cord-010119-t1x9gknd 5498 13 , , , cord-010119-t1x9gknd 5498 14 isolated isolate VBN cord-010119-t1x9gknd 5498 15 by by IN cord-010119-t1x9gknd 5498 16 207 207 CD cord-010119-t1x9gknd 5498 17 km km NN cord-010119-t1x9gknd 5498 18 sea sea NN cord-010119-t1x9gknd 5498 19 distance distance NN cord-010119-t1x9gknd 5498 20 to to IN cord-010119-t1x9gknd 5498 21 nearest near JJS cord-010119-t1x9gknd 5498 22 continental continental JJ cord-010119-t1x9gknd 5498 23 Spain Spain NNP cord-010119-t1x9gknd 5498 24 airport airport NN cord-010119-t1x9gknd 5498 25 , , , cord-010119-t1x9gknd 5498 26 with with IN cord-010119-t1x9gknd 5498 27 a a DT cord-010119-t1x9gknd 5498 28 general general JJ cord-010119-t1x9gknd 5498 29 hospital hospital NN cord-010119-t1x9gknd 5498 30 blood blood NN cord-010119-t1x9gknd 5498 31 transfusion transfusion NN cord-010119-t1x9gknd 5498 32 service service NN cord-010119-t1x9gknd 5498 33 and and CC cord-010119-t1x9gknd 5498 34 a a DT cord-010119-t1x9gknd 5498 35 establishment establishment NN cord-010119-t1x9gknd 5498 36 for for IN cord-010119-t1x9gknd 5498 37 blood blood NN cord-010119-t1x9gknd 5498 38 donation donation NN cord-010119-t1x9gknd 5498 39 and and CC cord-010119-t1x9gknd 5498 40 component component NN cord-010119-t1x9gknd 5498 41 production production NN cord-010119-t1x9gknd 5498 42 . . . cord-010119-t1x9gknd 5499 1 CL CL NNP cord-010119-t1x9gknd 5499 2 involved involve VBN cord-010119-t1x9gknd 5499 3 in in IN cord-010119-t1x9gknd 5499 4 anemia anemia NN cord-010119-t1x9gknd 5499 5 detection detection NN cord-010119-t1x9gknd 5499 6 and and CC cord-010119-t1x9gknd 5499 7 diagnosis diagnosis NN cord-010119-t1x9gknd 5499 8 receives receive VBZ cord-010119-t1x9gknd 5499 9 four four CD cord-010119-t1x9gknd 5499 10 primary primary JJ cord-010119-t1x9gknd 5499 11 care care NN cord-010119-t1x9gknd 5499 12 centers center NNS cord-010119-t1x9gknd 5499 13 and and CC cord-010119-t1x9gknd 5499 14 hospital hospital NN cord-010119-t1x9gknd 5499 15 based base VBN cord-010119-t1x9gknd 5499 16 samples sample NNS cord-010119-t1x9gknd 5499 17 , , , cord-010119-t1x9gknd 5499 18 and and CC cord-010119-t1x9gknd 5499 19 shares share VBZ cord-010119-t1x9gknd 5499 20 common common JJ cord-010119-t1x9gknd 5499 21 leadership leadership NN cord-010119-t1x9gknd 5499 22 with with IN cord-010119-t1x9gknd 5499 23 both both CC cord-010119-t1x9gknd 5499 24 blood blood NN cord-010119-t1x9gknd 5499 25 establishments establishment NNS cord-010119-t1x9gknd 5499 26 . . . cord-010119-t1x9gknd 5500 1 Process process NN cord-010119-t1x9gknd 5500 2 : : : cord-010119-t1x9gknd 5500 3 guidelines guideline NNS cord-010119-t1x9gknd 5500 4 for for IN cord-010119-t1x9gknd 5500 5 first first JJ cord-010119-t1x9gknd 5500 6 step step NN cord-010119-t1x9gknd 5500 7 CL CL NNP cord-010119-t1x9gknd 5500 8 diagnosis diagnosis NN cord-010119-t1x9gknd 5500 9 of of IN cord-010119-t1x9gknd 5500 10 IDA IDA NNP cord-010119-t1x9gknd 5500 11 and and CC cord-010119-t1x9gknd 5500 12 call call VB cord-010119-t1x9gknd 5500 13 for for IN cord-010119-t1x9gknd 5500 14 attention attention NN cord-010119-t1x9gknd 5500 15 , , , cord-010119-t1x9gknd 5500 16 primary primary JJ cord-010119-t1x9gknd 5500 17 oral oral JJ cord-010119-t1x9gknd 5500 18 iron iron NN cord-010119-t1x9gknd 5500 19 prevention prevention NN cord-010119-t1x9gknd 5500 20 and and CC cord-010119-t1x9gknd 5500 21 treatment treatment NN cord-010119-t1x9gknd 5500 22 in in IN cord-010119-t1x9gknd 5500 23 first first JJ cord-010119-t1x9gknd 5500 24 level level NN cord-010119-t1x9gknd 5500 25 care care NN cord-010119-t1x9gknd 5500 26 , , , cord-010119-t1x9gknd 5500 27 and and CC cord-010119-t1x9gknd 5500 28 early early JJ cord-010119-t1x9gknd 5500 29 intravenous intravenous JJ cord-010119-t1x9gknd 5500 30 iron iron NN cord-010119-t1x9gknd 5500 31 complex complex NN cord-010119-t1x9gknd 5500 32 for for IN cord-010119-t1x9gknd 5500 33 inpatients inpatient NNS cord-010119-t1x9gknd 5500 34 ( ( -LRB- cord-010119-t1x9gknd 5500 35 sucrose sucrose NN cord-010119-t1x9gknd 5500 36 ) ) -RRB- cord-010119-t1x9gknd 5500 37 and and CC cord-010119-t1x9gknd 5500 38 outpatients outpatient NNS cord-010119-t1x9gknd 5500 39 ( ( -LRB- cord-010119-t1x9gknd 5500 40 carboxymaltose carboxymaltose NNP cord-010119-t1x9gknd 5500 41 ) ) -RRB- cord-010119-t1x9gknd 5500 42 . . . cord-010119-t1x9gknd 5501 1 Transfusion transfusion NN cord-010119-t1x9gknd 5501 2 was be VBD cord-010119-t1x9gknd 5501 3 avoided avoid VBN cord-010119-t1x9gknd 5501 4 for for IN cord-010119-t1x9gknd 5501 5 stable stable JJ cord-010119-t1x9gknd 5501 6 IDA IDA NNP cord-010119-t1x9gknd 5501 7 patients patient NNS cord-010119-t1x9gknd 5501 8 without without IN cord-010119-t1x9gknd 5501 9 active active JJ cord-010119-t1x9gknd 5501 10 bleeding bleed VBG cord-010119-t1x9gknd 5501 11 or or CC cord-010119-t1x9gknd 5501 12 coronary coronary JJ cord-010119-t1x9gknd 5501 13 heart heart NN cord-010119-t1x9gknd 5501 14 disease disease NN cord-010119-t1x9gknd 5501 15 , , , cord-010119-t1x9gknd 5501 16 with with IN cord-010119-t1x9gknd 5501 17 a a DT cord-010119-t1x9gknd 5501 18 safety safety NN cord-010119-t1x9gknd 5501 19 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5501 20 ( ( -LRB- cord-010119-t1x9gknd 5501 21 Hb Hb NNP cord-010119-t1x9gknd 5501 22 ) ) -RRB- cord-010119-t1x9gknd 5501 23 threshold threshold NN cord-010119-t1x9gknd 5501 24 of of IN cord-010119-t1x9gknd 5501 25 5,5g 5,5g CD cord-010119-t1x9gknd 5501 26 / / SYM cord-010119-t1x9gknd 5501 27 dl dl NN cord-010119-t1x9gknd 5501 28 . . . cord-010119-t1x9gknd 5502 1 Severely severely RB cord-010119-t1x9gknd 5502 2 anemic anemic JJ cord-010119-t1x9gknd 5502 3 patients patient NNS cord-010119-t1x9gknd 5502 4 were be VBD cord-010119-t1x9gknd 5502 5 closely closely RB cord-010119-t1x9gknd 5502 6 followed follow VBN cord-010119-t1x9gknd 5502 7 to to IN cord-010119-t1x9gknd 5502 8 asses ass NNS cord-010119-t1x9gknd 5502 9 Hb Hb NNP cord-010119-t1x9gknd 5502 10 increase increase NN cord-010119-t1x9gknd 5502 11 and and CC cord-010119-t1x9gknd 5502 12 referred refer VBD cord-010119-t1x9gknd 5502 13 for for IN cord-010119-t1x9gknd 5502 14 etiology etiology NN cord-010119-t1x9gknd 5502 15 studies study NNS cord-010119-t1x9gknd 5502 16 when when WRB cord-010119-t1x9gknd 5502 17 Hb Hb NNP cord-010119-t1x9gknd 5502 18 > > XX cord-010119-t1x9gknd 5503 1 9 9 CD cord-010119-t1x9gknd 5503 2 g g NN cord-010119-t1x9gknd 5503 3 / / SYM cord-010119-t1x9gknd 5503 4 dl dl NN cord-010119-t1x9gknd 5503 5 . . . cord-010119-t1x9gknd 5504 1 Background Background NNP cord-010119-t1x9gknd 5504 2 / / SYM cord-010119-t1x9gknd 5504 3 Case Case NNP cord-010119-t1x9gknd 5504 4 Studies Studies NNPS cord-010119-t1x9gknd 5504 5 : : : cord-010119-t1x9gknd 5504 6 Bedside bedside NN cord-010119-t1x9gknd 5504 7 nurses nurse NNS cord-010119-t1x9gknd 5504 8 are be VBP cord-010119-t1x9gknd 5504 9 critical critical JJ cord-010119-t1x9gknd 5504 10 in in IN cord-010119-t1x9gknd 5504 11 safeguarding safeguard VBG cord-010119-t1x9gknd 5504 12 the the DT cord-010119-t1x9gknd 5504 13 delivery delivery NN cord-010119-t1x9gknd 5504 14 of of IN cord-010119-t1x9gknd 5504 15 appropriate appropriate JJ cord-010119-t1x9gknd 5504 16 patient patient NN cord-010119-t1x9gknd 5504 17 care care NN cord-010119-t1x9gknd 5504 18 . . . cord-010119-t1x9gknd 5505 1 More more RBR cord-010119-t1x9gknd 5505 2 recently recently RB cord-010119-t1x9gknd 5505 3 , , , cord-010119-t1x9gknd 5505 4 nurses nurse NNS cord-010119-t1x9gknd 5505 5 have have VBP cord-010119-t1x9gknd 5505 6 also also RB cord-010119-t1x9gknd 5505 7 begun begin VBN cord-010119-t1x9gknd 5505 8 to to TO cord-010119-t1x9gknd 5505 9 play play VB cord-010119-t1x9gknd 5505 10 an an DT cord-010119-t1x9gknd 5505 11 important important JJ cord-010119-t1x9gknd 5505 12 role role NN cord-010119-t1x9gknd 5505 13 in in IN cord-010119-t1x9gknd 5505 14 patient patient JJ cord-010119-t1x9gknd 5505 15 blood blood NN cord-010119-t1x9gknd 5505 16 management management NN cord-010119-t1x9gknd 5505 17 ( ( -LRB- cord-010119-t1x9gknd 5505 18 PBM PBM NNP cord-010119-t1x9gknd 5505 19 ) ) -RRB- cord-010119-t1x9gknd 5505 20 programs program NNS cord-010119-t1x9gknd 5505 21 at at IN cord-010119-t1x9gknd 5505 22 the the DT cord-010119-t1x9gknd 5505 23 administrative administrative JJ cord-010119-t1x9gknd 5505 24 level level NN cord-010119-t1x9gknd 5505 25 , , , cord-010119-t1x9gknd 5505 26 although although IN cord-010119-t1x9gknd 5505 27 to to IN cord-010119-t1x9gknd 5505 28 our -PRON- PRP$ cord-010119-t1x9gknd 5505 29 knowledge knowledge NN cord-010119-t1x9gknd 5505 30 little little JJ cord-010119-t1x9gknd 5505 31 has have VBZ cord-010119-t1x9gknd 5505 32 been be VBN cord-010119-t1x9gknd 5505 33 published publish VBN cord-010119-t1x9gknd 5505 34 on on IN cord-010119-t1x9gknd 5505 35 the the DT cord-010119-t1x9gknd 5505 36 influence influence NN cord-010119-t1x9gknd 5505 37 nurses nurse NNS cord-010119-t1x9gknd 5505 38 may may MD cord-010119-t1x9gknd 5505 39 have have VB cord-010119-t1x9gknd 5505 40 on on IN cord-010119-t1x9gknd 5505 41 transfusion transfusion NN cord-010119-t1x9gknd 5505 42 practice practice NN cord-010119-t1x9gknd 5505 43 at at IN cord-010119-t1x9gknd 5505 44 the the DT cord-010119-t1x9gknd 5505 45 bedside bedside NN cord-010119-t1x9gknd 5505 46 . . . cord-010119-t1x9gknd 5506 1 The the DT cord-010119-t1x9gknd 5506 2 goal goal NN cord-010119-t1x9gknd 5506 3 of of IN cord-010119-t1x9gknd 5506 4 this this DT cord-010119-t1x9gknd 5506 5 study study NN cord-010119-t1x9gknd 5506 6 was be VBD cord-010119-t1x9gknd 5506 7 to to TO cord-010119-t1x9gknd 5506 8 evaluate evaluate VB cord-010119-t1x9gknd 5506 9 the the DT cord-010119-t1x9gknd 5506 10 impact impact NN cord-010119-t1x9gknd 5506 11 nurses nurse NNS cord-010119-t1x9gknd 5506 12 have have VBP cord-010119-t1x9gknd 5506 13 on on IN cord-010119-t1x9gknd 5506 14 patient patient JJ cord-010119-t1x9gknd 5506 15 expectations expectation NNS cord-010119-t1x9gknd 5506 16 and and CC cord-010119-t1x9gknd 5506 17 physician physician NN cord-010119-t1x9gknd 5506 18 ordering ordering NN cord-010119-t1x9gknd 5506 19 practice practice NN cord-010119-t1x9gknd 5506 20 . . . cord-010119-t1x9gknd 5507 1 Study Study NNP cord-010119-t1x9gknd 5507 2 Design Design NNP cord-010119-t1x9gknd 5507 3 / / SYM cord-010119-t1x9gknd 5507 4 Method method NN cord-010119-t1x9gknd 5507 5 : : : cord-010119-t1x9gknd 5508 1 A a DT cord-010119-t1x9gknd 5508 2 short short JJ cord-010119-t1x9gknd 5508 3 electronic electronic JJ cord-010119-t1x9gknd 5508 4 survey survey NN cord-010119-t1x9gknd 5508 5 ( ( -LRB- cord-010119-t1x9gknd 5508 6 12 12 CD cord-010119-t1x9gknd 5508 7 questions question NNS cord-010119-t1x9gknd 5508 8 ) ) -RRB- cord-010119-t1x9gknd 5508 9 was be VBD cord-010119-t1x9gknd 5508 10 prepared prepared JJ cord-010119-t1x9gknd 5508 11 to to TO cord-010119-t1x9gknd 5508 12 assess assess VB cord-010119-t1x9gknd 5508 13 how how WRB cord-010119-t1x9gknd 5508 14 often often RB cord-010119-t1x9gknd 5508 15 bedside bedside NN cord-010119-t1x9gknd 5508 16 nurses nurse NNS cord-010119-t1x9gknd 5508 17 discussed discuss VBD cord-010119-t1x9gknd 5508 18 transfusion transfusion NN cord-010119-t1x9gknd 5508 19 necessity necessity NN cord-010119-t1x9gknd 5508 20 and and CC cord-010119-t1x9gknd 5508 21 the the DT cord-010119-t1x9gknd 5508 22 persons person NNS cord-010119-t1x9gknd 5508 23 ( ( -LRB- cord-010119-t1x9gknd 5508 24 patient patient JJ cord-010119-t1x9gknd 5508 25 or or CC cord-010119-t1x9gknd 5508 26 physician physician NN cord-010119-t1x9gknd 5508 27 ) ) -RRB- cord-010119-t1x9gknd 5508 28 with with IN cord-010119-t1x9gknd 5508 29 whom whom WP cord-010119-t1x9gknd 5508 30 they -PRON- PRP cord-010119-t1x9gknd 5508 31 discussed discuss VBD cord-010119-t1x9gknd 5508 32 it -PRON- PRP cord-010119-t1x9gknd 5508 33 with with IN cord-010119-t1x9gknd 5508 34 , , , cord-010119-t1x9gknd 5508 35 as as RB cord-010119-t1x9gknd 5508 36 well well RB cord-010119-t1x9gknd 5508 37 as as IN cord-010119-t1x9gknd 5508 38 what what WP cord-010119-t1x9gknd 5508 39 was be VBD cord-010119-t1x9gknd 5508 40 discussed discuss VBN cord-010119-t1x9gknd 5508 41 , , , cord-010119-t1x9gknd 5508 42 and and CC cord-010119-t1x9gknd 5508 43 what what WP cord-010119-t1x9gknd 5508 44 they -PRON- PRP cord-010119-t1x9gknd 5508 45 felt feel VBD cord-010119-t1x9gknd 5508 46 were be VBD cord-010119-t1x9gknd 5508 47 appropriate appropriate JJ cord-010119-t1x9gknd 5508 48 lab lab NN cord-010119-t1x9gknd 5508 49 thresholds threshold NNS cord-010119-t1x9gknd 5508 50 for for IN cord-010119-t1x9gknd 5508 51 transfusion transfusion NN cord-010119-t1x9gknd 5508 52 . . . cord-010119-t1x9gknd 5509 1 The the DT cord-010119-t1x9gknd 5509 2 survey survey NN cord-010119-t1x9gknd 5509 3 was be VBD cord-010119-t1x9gknd 5509 4 distributed distribute VBN cord-010119-t1x9gknd 5509 5 to to IN cord-010119-t1x9gknd 5509 6 all all DT cord-010119-t1x9gknd 5509 7 registered register VBN cord-010119-t1x9gknd 5509 8 nurses nurse NNS cord-010119-t1x9gknd 5509 9 via via IN cord-010119-t1x9gknd 5509 10 email email NN cord-010119-t1x9gknd 5509 11 from from IN cord-010119-t1x9gknd 5509 12 floor floor NN cord-010119-t1x9gknd 5509 13 leaders leader NNS cord-010119-t1x9gknd 5509 14 . . . cord-010119-t1x9gknd 5510 1 Responses response NNS cord-010119-t1x9gknd 5510 2 were be VBD cord-010119-t1x9gknd 5510 3 also also RB cord-010119-t1x9gknd 5510 4 solicited solicit VBN cord-010119-t1x9gknd 5510 5 by by IN cord-010119-t1x9gknd 5510 6 hospital hospital NN cord-010119-t1x9gknd 5510 7 volunteers volunteer NNS cord-010119-t1x9gknd 5510 8 and and CC cord-010119-t1x9gknd 5510 9 lab lab NN cord-010119-t1x9gknd 5510 10 staff staff NN cord-010119-t1x9gknd 5510 11 with with IN cord-010119-t1x9gknd 5510 12 electronic electronic JJ cord-010119-t1x9gknd 5510 13 tablets tablet NNS cord-010119-t1x9gknd 5510 14 and and CC cord-010119-t1x9gknd 5510 15 included include VBN cord-010119-t1x9gknd 5510 16 coverage coverage NN cord-010119-t1x9gknd 5510 17 of of IN cord-010119-t1x9gknd 5510 18 the the DT cord-010119-t1x9gknd 5510 19 night night NN cord-010119-t1x9gknd 5510 20 shift shift NN cord-010119-t1x9gknd 5510 21 . . . cord-010119-t1x9gknd 5511 1 Results result NNS cord-010119-t1x9gknd 5512 1 /Finding /finde VBG cord-010119-t1x9gknd 5512 2 : : : cord-010119-t1x9gknd 5512 3 There there EX cord-010119-t1x9gknd 5512 4 were be VBD cord-010119-t1x9gknd 5512 5 a a DT cord-010119-t1x9gknd 5512 6 total total NN cord-010119-t1x9gknd 5512 7 of of IN cord-010119-t1x9gknd 5512 8 32 32 CD cord-010119-t1x9gknd 5512 9 complete complete JJ cord-010119-t1x9gknd 5512 10 responses response NNS cord-010119-t1x9gknd 5512 11 ( ( -LRB- cord-010119-t1x9gknd 5512 12 16 16 CD cord-010119-t1x9gknd 5512 13 % % NN cord-010119-t1x9gknd 5512 14 ) ) -RRB- cord-010119-t1x9gknd 5512 15 . . . cord-010119-t1x9gknd 5513 1 The the DT cord-010119-t1x9gknd 5513 2 nurses nurse NNS cord-010119-t1x9gknd 5513 3 had have VBD cord-010119-t1x9gknd 5513 4 a a DT cord-010119-t1x9gknd 5513 5 range range NN cord-010119-t1x9gknd 5513 6 of of IN cord-010119-t1x9gknd 5513 7 experience experience NN cord-010119-t1x9gknd 5513 8 from from IN cord-010119-t1x9gknd 5513 9 less less JJR cord-010119-t1x9gknd 5513 10 than than IN cord-010119-t1x9gknd 5513 11 one one CD cord-010119-t1x9gknd 5513 12 year year NN cord-010119-t1x9gknd 5513 13 to to IN cord-010119-t1x9gknd 5513 14 forty forty CD cord-010119-t1x9gknd 5513 15 years year NNS cord-010119-t1x9gknd 5513 16 . . . cord-010119-t1x9gknd 5514 1 Ninety ninety CD cord-010119-t1x9gknd 5514 2 percent percent NN cord-010119-t1x9gknd 5514 3 stated state VBD cord-010119-t1x9gknd 5514 4 they -PRON- PRP cord-010119-t1x9gknd 5514 5 discussed discuss VBD cord-010119-t1x9gknd 5514 6 transfusion transfusion NN cord-010119-t1x9gknd 5514 7 necessity necessity NN cord-010119-t1x9gknd 5514 8 with with IN cord-010119-t1x9gknd 5514 9 patients patient NNS cord-010119-t1x9gknd 5514 10 , , , cord-010119-t1x9gknd 5514 11 81 81 CD cord-010119-t1x9gknd 5514 12 % % NN cord-010119-t1x9gknd 5514 13 with with IN cord-010119-t1x9gknd 5514 14 physicians physician NNS cord-010119-t1x9gknd 5514 15 , , , cord-010119-t1x9gknd 5514 16 and and CC cord-010119-t1x9gknd 5514 17 of of IN cord-010119-t1x9gknd 5514 18 these these DT cord-010119-t1x9gknd 5514 19 , , , cord-010119-t1x9gknd 5514 20 59 59 CD cord-010119-t1x9gknd 5514 21 % % NN cord-010119-t1x9gknd 5514 22 reported report VBD cord-010119-t1x9gknd 5514 23 doing do VBG cord-010119-t1x9gknd 5514 24 so so RB cord-010119-t1x9gknd 5514 25 proactively proactively RB cord-010119-t1x9gknd 5514 26 before before IN cord-010119-t1x9gknd 5514 27 an an DT cord-010119-t1x9gknd 5514 28 order order NN cord-010119-t1x9gknd 5514 29 was be VBD cord-010119-t1x9gknd 5514 30 placed place VBN cord-010119-t1x9gknd 5514 31 . . . cord-010119-t1x9gknd 5515 1 Ninety ninety CD cord-010119-t1x9gknd 5515 2 - - HYPH cord-010119-t1x9gknd 5515 3 six six CD cord-010119-t1x9gknd 5515 4 percent percent NN cord-010119-t1x9gknd 5515 5 said say VBD cord-010119-t1x9gknd 5515 6 they -PRON- PRP cord-010119-t1x9gknd 5515 7 would would MD cord-010119-t1x9gknd 5515 8 discuss discuss VB cord-010119-t1x9gknd 5515 9 transfusion transfusion NN cord-010119-t1x9gknd 5515 10 to to TO cord-010119-t1x9gknd 5515 11 suggest suggest VB cord-010119-t1x9gknd 5515 12 their -PRON- PRP$ cord-010119-t1x9gknd 5515 13 patient patient NN cord-010119-t1x9gknd 5515 14 required require VBD cord-010119-t1x9gknd 5515 15 a a DT cord-010119-t1x9gknd 5515 16 blood blood NN cord-010119-t1x9gknd 5515 17 product product NN cord-010119-t1x9gknd 5515 18 ; ; : cord-010119-t1x9gknd 5515 19 only only RB cord-010119-t1x9gknd 5515 20 3 3 CD cord-010119-t1x9gknd 5515 21 % % NN cord-010119-t1x9gknd 5515 22 responded respond VBD cord-010119-t1x9gknd 5515 23 that that IN cord-010119-t1x9gknd 5515 24 they -PRON- PRP cord-010119-t1x9gknd 5515 25 would would MD cord-010119-t1x9gknd 5515 26 suggest suggest VB cord-010119-t1x9gknd 5515 27 product product NN cord-010119-t1x9gknd 5515 28 was be VBD cord-010119-t1x9gknd 5515 29 not not RB cord-010119-t1x9gknd 5515 30 needed need VBN cord-010119-t1x9gknd 5515 31 . . . cord-010119-t1x9gknd 5516 1 Nursing nursing NN cord-010119-t1x9gknd 5516 2 perception perception NN cord-010119-t1x9gknd 5516 3 of of IN cord-010119-t1x9gknd 5516 4 acceptable acceptable JJ cord-010119-t1x9gknd 5516 5 transfusion transfusion NN cord-010119-t1x9gknd 5516 6 thresholds threshold NNS cord-010119-t1x9gknd 5516 7 had have VBD cord-010119-t1x9gknd 5516 8 a a DT cord-010119-t1x9gknd 5516 9 wider wide JJR cord-010119-t1x9gknd 5516 10 distribution distribution NN cord-010119-t1x9gknd 5516 11 , , , cord-010119-t1x9gknd 5516 12 with with IN cord-010119-t1x9gknd 5516 13 the the DT cord-010119-t1x9gknd 5516 14 most most RBS cord-010119-t1x9gknd 5516 15 commonly commonly RB cord-010119-t1x9gknd 5516 16 reported report VBN cord-010119-t1x9gknd 5516 17 values value NNS cord-010119-t1x9gknd 5516 18 being be VBG cord-010119-t1x9gknd 5516 19 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5516 20 of of IN cord-010119-t1x9gknd 5516 21 7 7 CD cord-010119-t1x9gknd 5516 22 - - SYM cord-010119-t1x9gknd 5516 23 8 8 CD cord-010119-t1x9gknd 5516 24 g g NN cord-010119-t1x9gknd 5516 25 / / SYM cord-010119-t1x9gknd 5516 26 dL dl NN cord-010119-t1x9gknd 5516 27 ( ( -LRB- cord-010119-t1x9gknd 5516 28 56 56 CD cord-010119-t1x9gknd 5516 29 % % NN cord-010119-t1x9gknd 5516 30 ) ) -RRB- cord-010119-t1x9gknd 5516 31 , , , cord-010119-t1x9gknd 5516 32 platelet platelet NN cord-010119-t1x9gknd 5516 33 count count NN cord-010119-t1x9gknd 5516 34 of of IN cord-010119-t1x9gknd 5516 35 20 20 CD cord-010119-t1x9gknd 5516 36 - - SYM cord-010119-t1x9gknd 5516 37 50,000 50,000 CD cord-010119-t1x9gknd 5516 38 ( ( -LRB- cord-010119-t1x9gknd 5516 39 38 38 CD cord-010119-t1x9gknd 5516 40 % % NN cord-010119-t1x9gknd 5516 41 ) ) -RRB- cord-010119-t1x9gknd 5516 42 , , , cord-010119-t1x9gknd 5516 43 and and CC cord-010119-t1x9gknd 5516 44 INR INR NNP cord-010119-t1x9gknd 5516 45 of of IN cord-010119-t1x9gknd 5516 46 greater great JJR cord-010119-t1x9gknd 5516 47 than than IN cord-010119-t1x9gknd 5516 48 2.0 2.0 CD cord-010119-t1x9gknd 5516 49 ( ( -LRB- cord-010119-t1x9gknd 5516 50 69 69 CD cord-010119-t1x9gknd 5516 51 % % NN cord-010119-t1x9gknd 5516 52 ) ) -RRB- cord-010119-t1x9gknd 5516 53 . . . cord-010119-t1x9gknd 5517 1 Conclusion conclusion NN cord-010119-t1x9gknd 5517 2 : : : cord-010119-t1x9gknd 5518 1 This this DT cord-010119-t1x9gknd 5518 2 study study NN cord-010119-t1x9gknd 5518 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 5518 4 that that IN cord-010119-t1x9gknd 5518 5 nurses nurse NNS cord-010119-t1x9gknd 5518 6 are be VBP cord-010119-t1x9gknd 5518 7 willing willing JJ cord-010119-t1x9gknd 5518 8 to to TO cord-010119-t1x9gknd 5518 9 discuss discuss VB cord-010119-t1x9gknd 5518 10 transfusions transfusion NNS cord-010119-t1x9gknd 5518 11 with with IN cord-010119-t1x9gknd 5518 12 both both DT cord-010119-t1x9gknd 5518 13 patients patient NNS cord-010119-t1x9gknd 5518 14 and and CC cord-010119-t1x9gknd 5518 15 providers provider NNS cord-010119-t1x9gknd 5518 16 , , , cord-010119-t1x9gknd 5518 17 although although IN cord-010119-t1x9gknd 5518 18 they -PRON- PRP cord-010119-t1x9gknd 5518 19 appear appear VBP cord-010119-t1x9gknd 5518 20 to to TO cord-010119-t1x9gknd 5518 21 be be VB cord-010119-t1x9gknd 5518 22 most most RBS cord-010119-t1x9gknd 5518 23 comfortable comfortable JJ cord-010119-t1x9gknd 5518 24 doing do VBG cord-010119-t1x9gknd 5518 25 so so RB cord-010119-t1x9gknd 5518 26 in in IN cord-010119-t1x9gknd 5518 27 the the DT cord-010119-t1x9gknd 5518 28 setting setting NN cord-010119-t1x9gknd 5518 29 of of IN cord-010119-t1x9gknd 5518 30 perceived perceive VBN cord-010119-t1x9gknd 5518 31 transfusion transfusion NN cord-010119-t1x9gknd 5518 32 necessity necessity NN cord-010119-t1x9gknd 5518 33 . . . cord-010119-t1x9gknd 5519 1 The the DT cord-010119-t1x9gknd 5519 2 limited limited JJ cord-010119-t1x9gknd 5519 3 number number NN cord-010119-t1x9gknd 5519 4 of of IN cord-010119-t1x9gknd 5519 5 survey survey NN cord-010119-t1x9gknd 5519 6 responses response NNS cord-010119-t1x9gknd 5519 7 suggests suggest VBZ cord-010119-t1x9gknd 5519 8 a a DT cord-010119-t1x9gknd 5519 9 discomfort discomfort NN cord-010119-t1x9gknd 5519 10 with with IN cord-010119-t1x9gknd 5519 11 their -PRON- PRP$ cord-010119-t1x9gknd 5519 12 level level NN cord-010119-t1x9gknd 5519 13 of of IN cord-010119-t1x9gknd 5519 14 education education NN cord-010119-t1x9gknd 5519 15 in in IN cord-010119-t1x9gknd 5519 16 transfusion transfusion NN cord-010119-t1x9gknd 5519 17 practice practice NN cord-010119-t1x9gknd 5519 18 . . . cord-010119-t1x9gknd 5520 1 This this DT cord-010119-t1x9gknd 5520 2 , , , cord-010119-t1x9gknd 5520 3 along along IN cord-010119-t1x9gknd 5520 4 with with IN cord-010119-t1x9gknd 5520 5 the the DT cord-010119-t1x9gknd 5520 6 distribution distribution NN cord-010119-t1x9gknd 5520 7 of of IN cord-010119-t1x9gknd 5520 8 perceived perceive VBN cord-010119-t1x9gknd 5520 9 thresholds threshold NNS cord-010119-t1x9gknd 5520 10 and and CC cord-010119-t1x9gknd 5520 11 the the DT cord-010119-t1x9gknd 5520 12 reluctance reluctance NN cord-010119-t1x9gknd 5520 13 to to TO cord-010119-t1x9gknd 5520 14 recommend recommend VB cord-010119-t1x9gknd 5520 15 against against IN cord-010119-t1x9gknd 5520 16 transfusions transfusion NNS cord-010119-t1x9gknd 5520 17 , , , cord-010119-t1x9gknd 5520 18 presents present VBZ cord-010119-t1x9gknd 5520 19 an an DT cord-010119-t1x9gknd 5520 20 opportunity opportunity NN cord-010119-t1x9gknd 5520 21 for for IN cord-010119-t1x9gknd 5520 22 education education NN cord-010119-t1x9gknd 5520 23 to to TO cord-010119-t1x9gknd 5520 24 further further RB cord-010119-t1x9gknd 5520 25 empower empower VB cord-010119-t1x9gknd 5520 26 nurses nurse NNS cord-010119-t1x9gknd 5520 27 in in IN cord-010119-t1x9gknd 5520 28 providing provide VBG cord-010119-t1x9gknd 5520 29 appropriate appropriate JJ cord-010119-t1x9gknd 5520 30 patient patient NN cord-010119-t1x9gknd 5520 31 care care NN cord-010119-t1x9gknd 5520 32 within within IN cord-010119-t1x9gknd 5520 33 the the DT cord-010119-t1x9gknd 5520 34 guidelines guideline NNS cord-010119-t1x9gknd 5520 35 of of IN cord-010119-t1x9gknd 5520 36 PBM PBM NNP cord-010119-t1x9gknd 5520 37 programs program NNS cord-010119-t1x9gknd 5520 38 . . . cord-010119-t1x9gknd 5521 1 Background Background NNP cord-010119-t1x9gknd 5521 2 / / SYM cord-010119-t1x9gknd 5521 3 Case Case NNP cord-010119-t1x9gknd 5521 4 Studies Studies NNPS cord-010119-t1x9gknd 5521 5 : : : cord-010119-t1x9gknd 5522 1 The the DT cord-010119-t1x9gknd 5522 2 use use NN cord-010119-t1x9gknd 5522 3 of of IN cord-010119-t1x9gknd 5522 4 red red JJ cord-010119-t1x9gknd 5522 5 blood blood NN cord-010119-t1x9gknd 5522 6 cell cell NN cord-010119-t1x9gknd 5522 7 per per IN cord-010119-t1x9gknd 5522 8 1,000 1,000 CD cord-010119-t1x9gknd 5522 9 inhabitants inhabitant NNS cord-010119-t1x9gknd 5522 10 may may MD cord-010119-t1x9gknd 5522 11 vary vary VB cord-010119-t1x9gknd 5522 12 3 3 CD cord-010119-t1x9gknd 5522 13 folds fold NNS cord-010119-t1x9gknd 5522 14 between between IN cord-010119-t1x9gknd 5522 15 European european JJ cord-010119-t1x9gknd 5522 16 countries country NNS cord-010119-t1x9gknd 5522 17 , , , cord-010119-t1x9gknd 5522 18 revealing reveal VBG cord-010119-t1x9gknd 5522 19 that that IN cord-010119-t1x9gknd 5522 20 there there EX cord-010119-t1x9gknd 5522 21 may may MD cord-010119-t1x9gknd 5522 22 be be VB cord-010119-t1x9gknd 5522 23 substantial substantial JJ cord-010119-t1x9gknd 5522 24 room room NN cord-010119-t1x9gknd 5522 25 for for IN cord-010119-t1x9gknd 5522 26 blood blood NN cord-010119-t1x9gknd 5522 27 optimization optimization NN cord-010119-t1x9gknd 5522 28 strategies strategy NNS cord-010119-t1x9gknd 5522 29 . . . cord-010119-t1x9gknd 5523 1 Patient Patient NNP cord-010119-t1x9gknd 5523 2 Blood Blood NNP cord-010119-t1x9gknd 5523 3 Management Management NNP cord-010119-t1x9gknd 5523 4 ( ( -LRB- cord-010119-t1x9gknd 5523 5 PBM PBM NNP cord-010119-t1x9gknd 5523 6 ) ) -RRB- cord-010119-t1x9gknd 5523 7 is be VBZ cord-010119-t1x9gknd 5523 8 an an DT cord-010119-t1x9gknd 5523 9 evidence evidence NN cord-010119-t1x9gknd 5523 10 - - HYPH cord-010119-t1x9gknd 5523 11 based base VBN cord-010119-t1x9gknd 5523 12 , , , cord-010119-t1x9gknd 5523 13 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 5523 14 approach approach NN cord-010119-t1x9gknd 5523 15 aiming aim VBG cord-010119-t1x9gknd 5523 16 to to TO cord-010119-t1x9gknd 5523 17 preserve preserve VB cord-010119-t1x9gknd 5523 18 and and CC cord-010119-t1x9gknd 5523 19 optimise optimise VB cord-010119-t1x9gknd 5523 20 patients patient NNS cord-010119-t1x9gknd 5523 21 ' ' POS cord-010119-t1x9gknd 5523 22 own own JJ cord-010119-t1x9gknd 5523 23 blood blood NN cord-010119-t1x9gknd 5523 24 in in IN cord-010119-t1x9gknd 5523 25 order order NN cord-010119-t1x9gknd 5523 26 to to TO cord-010119-t1x9gknd 5523 27 improve improve VB cord-010119-t1x9gknd 5523 28 clinical clinical JJ cord-010119-t1x9gknd 5523 29 outcomes outcome NNS cord-010119-t1x9gknd 5523 30 . . . cord-010119-t1x9gknd 5524 1 The the DT cord-010119-t1x9gknd 5524 2 objective objective NN cord-010119-t1x9gknd 5524 3 of of IN cord-010119-t1x9gknd 5524 4 our -PRON- PRP$ cord-010119-t1x9gknd 5524 5 study study NN cord-010119-t1x9gknd 5524 6 was be VBD cord-010119-t1x9gknd 5524 7 to to TO cord-010119-t1x9gknd 5524 8 assess assess VB cord-010119-t1x9gknd 5524 9 the the DT cord-010119-t1x9gknd 5524 10 effect effect NN cord-010119-t1x9gknd 5524 11 of of IN cord-010119-t1x9gknd 5524 12 a a DT cord-010119-t1x9gknd 5524 13 nationwide nationwide JJ cord-010119-t1x9gknd 5524 14 PBM PBM NNP cord-010119-t1x9gknd 5524 15 program program NN cord-010119-t1x9gknd 5524 16 on on IN cord-010119-t1x9gknd 5524 17 public public JJ cord-010119-t1x9gknd 5524 18 health health NN cord-010119-t1x9gknd 5524 19 in in IN cord-010119-t1x9gknd 5524 20 Portugal Portugal NNP cord-010119-t1x9gknd 5524 21 . . . cord-010119-t1x9gknd 5525 1 Study Study NNP cord-010119-t1x9gknd 5525 2 Design Design NNP cord-010119-t1x9gknd 5525 3 / / SYM cord-010119-t1x9gknd 5525 4 Method method NN cord-010119-t1x9gknd 5525 5 : : : cord-010119-t1x9gknd 5526 1 The the DT cord-010119-t1x9gknd 5526 2 first first JJ cord-010119-t1x9gknd 5526 3 phase phase NN cord-010119-t1x9gknd 5526 4 of of IN cord-010119-t1x9gknd 5526 5 this this DT cord-010119-t1x9gknd 5526 6 research research NN cord-010119-t1x9gknd 5526 7 project project NN cord-010119-t1x9gknd 5526 8 involved involve VBD cord-010119-t1x9gknd 5526 9 a a DT cord-010119-t1x9gknd 5526 10 group group NN cord-010119-t1x9gknd 5526 11 of of IN cord-010119-t1x9gknd 5526 12 18 18 CD cord-010119-t1x9gknd 5526 13 key key JJ cord-010119-t1x9gknd 5526 14 opinion opinion NN cord-010119-t1x9gknd 5526 15 leaders leader NNS cord-010119-t1x9gknd 5526 16 ( ( -LRB- cord-010119-t1x9gknd 5526 17 KOL KOL NNP cord-010119-t1x9gknd 5526 18 ) ) -RRB- cord-010119-t1x9gknd 5526 19 in in IN cord-010119-t1x9gknd 5526 20 a a DT cord-010119-t1x9gknd 5526 21 stated state VBN cord-010119-t1x9gknd 5526 22 preference preference NN cord-010119-t1x9gknd 5526 23 inquiry inquiry NN cord-010119-t1x9gknd 5526 24 to to TO cord-010119-t1x9gknd 5526 25 assess assess VB cord-010119-t1x9gknd 5526 26 the the DT cord-010119-t1x9gknd 5526 27 relative relative JJ cord-010119-t1x9gknd 5526 28 value value NN cord-010119-t1x9gknd 5526 29 of of IN cord-010119-t1x9gknd 5526 30 specific specific JJ cord-010119-t1x9gknd 5526 31 PBM PBM NNP cord-010119-t1x9gknd 5526 32 strategies strategy NNS cord-010119-t1x9gknd 5526 33 , , , cord-010119-t1x9gknd 5526 34 grouped group VBN cord-010119-t1x9gknd 5526 35 in in IN cord-010119-t1x9gknd 5526 36 PBM PBM NNP cord-010119-t1x9gknd 5526 37 pillars pillar NNS cord-010119-t1x9gknd 5526 38 , , , cord-010119-t1x9gknd 5526 39 to to TO cord-010119-t1x9gknd 5526 40 highlight highlight VB cord-010119-t1x9gknd 5526 41 the the DT cord-010119-t1x9gknd 5526 42 need need NN cord-010119-t1x9gknd 5526 43 for for IN cord-010119-t1x9gknd 5526 44 strategy strategy NN cord-010119-t1x9gknd 5526 45 prioritization prioritization NN cord-010119-t1x9gknd 5526 46 in in IN cord-010119-t1x9gknd 5526 47 the the DT cord-010119-t1x9gknd 5526 48 implementation implementation NN cord-010119-t1x9gknd 5526 49 of of IN cord-010119-t1x9gknd 5526 50 a a DT cord-010119-t1x9gknd 5526 51 nationwide nationwide JJ cord-010119-t1x9gknd 5526 52 PBM PBM NNP cord-010119-t1x9gknd 5526 53 policy policy NN cord-010119-t1x9gknd 5526 54 . . . cord-010119-t1x9gknd 5527 1 Adaptive adaptive JJ cord-010119-t1x9gknd 5527 2 conjoint conjoint JJ cord-010119-t1x9gknd 5527 3 analysis analysis NN cord-010119-t1x9gknd 5527 4 techniques technique NNS cord-010119-t1x9gknd 5527 5 were be VBD cord-010119-t1x9gknd 5527 6 used use VBN cord-010119-t1x9gknd 5527 7 to to TO cord-010119-t1x9gknd 5527 8 elicit elicit VB cord-010119-t1x9gknd 5527 9 KOL KOL NNP cord-010119-t1x9gknd 5527 10 preferences preference NNS cord-010119-t1x9gknd 5527 11 . . . cord-010119-t1x9gknd 5528 1 In in IN cord-010119-t1x9gknd 5528 2 the the DT cord-010119-t1x9gknd 5528 3 second second JJ cord-010119-t1x9gknd 5528 4 phase phase NN cord-010119-t1x9gknd 5528 5 a a DT cord-010119-t1x9gknd 5528 6 decision decision NN cord-010119-t1x9gknd 5528 7 analysis analysis NN cord-010119-t1x9gknd 5528 8 model model NN cord-010119-t1x9gknd 5528 9 was be VBD cord-010119-t1x9gknd 5528 10 used use VBN cord-010119-t1x9gknd 5528 11 to to TO cord-010119-t1x9gknd 5528 12 estimate estimate VB cord-010119-t1x9gknd 5528 13 the the DT cord-010119-t1x9gknd 5528 14 impact impact NN cord-010119-t1x9gknd 5528 15 of of IN cord-010119-t1x9gknd 5528 16 PBM PBM NNP cord-010119-t1x9gknd 5528 17 implementation implementation NN cord-010119-t1x9gknd 5528 18 in in IN cord-010119-t1x9gknd 5528 19 the the DT cord-010119-t1x9gknd 5528 20 following follow VBG cord-010119-t1x9gknd 5528 21 therapeutic therapeutic JJ cord-010119-t1x9gknd 5528 22 areas area NNS cord-010119-t1x9gknd 5528 23 : : : cord-010119-t1x9gknd 5528 24 surgery surgery NN cord-010119-t1x9gknd 5528 25 ( ( -LRB- cord-010119-t1x9gknd 5528 26 orthopaedic orthopaedic JJ cord-010119-t1x9gknd 5528 27 , , , cord-010119-t1x9gknd 5528 28 cardiac cardiac JJ cord-010119-t1x9gknd 5528 29 and and CC cord-010119-t1x9gknd 5528 30 urologic urologic JJ cord-010119-t1x9gknd 5528 31 ) ) -RRB- cord-010119-t1x9gknd 5528 32 , , , cord-010119-t1x9gknd 5528 33 cardiology cardiology NN cord-010119-t1x9gknd 5528 34 , , , cord-010119-t1x9gknd 5528 35 oncology oncology NN cord-010119-t1x9gknd 5528 36 , , , cord-010119-t1x9gknd 5528 37 gastrointestinal gastrointestinal JJ cord-010119-t1x9gknd 5528 38 bleeding bleeding NN cord-010119-t1x9gknd 5528 39 , , , cord-010119-t1x9gknd 5528 40 abnormal abnormal JJ cord-010119-t1x9gknd 5528 41 uterine uterine NN cord-010119-t1x9gknd 5528 42 bleeding bleeding NN cord-010119-t1x9gknd 5528 43 , , , cord-010119-t1x9gknd 5528 44 haemodialysis haemodialysis NNP cord-010119-t1x9gknd 5528 45 , , , cord-010119-t1x9gknd 5528 46 inflammatory inflammatory JJ cord-010119-t1x9gknd 5528 47 bowel bowel NN cord-010119-t1x9gknd 5528 48 disease disease NN cord-010119-t1x9gknd 5528 49 and and CC cord-010119-t1x9gknd 5528 50 pregnancy pregnancy NN cord-010119-t1x9gknd 5528 51 . . . cord-010119-t1x9gknd 5529 1 Model model NN cord-010119-t1x9gknd 5529 2 inputs input NNS cord-010119-t1x9gknd 5529 3 included include VBD cord-010119-t1x9gknd 5529 4 effectiveness effectiveness NN cord-010119-t1x9gknd 5529 5 data datum NNS cord-010119-t1x9gknd 5529 6 regarding regard VBG cord-010119-t1x9gknd 5529 7 transfusion transfusion NN cord-010119-t1x9gknd 5529 8 utilization utilization NN cord-010119-t1x9gknd 5529 9 , , , cord-010119-t1x9gknd 5529 10 health health NN cord-010119-t1x9gknd 5529 11 resource resource NN cord-010119-t1x9gknd 5529 12 consumption consumption NN cord-010119-t1x9gknd 5529 13 and and CC cord-010119-t1x9gknd 5529 14 mortality mortality NN cord-010119-t1x9gknd 5529 15 obtained obtain VBN cord-010119-t1x9gknd 5529 16 from from IN cord-010119-t1x9gknd 5529 17 Portuguese portuguese JJ cord-010119-t1x9gknd 5529 18 national national JJ cord-010119-t1x9gknd 5529 19 health health NN cord-010119-t1x9gknd 5529 20 databases database NNS cord-010119-t1x9gknd 5529 21 and and CC cord-010119-t1x9gknd 5529 22 literature literature NN cord-010119-t1x9gknd 5529 23 review review NN cord-010119-t1x9gknd 5529 24 . . . cord-010119-t1x9gknd 5530 1 The the DT cord-010119-t1x9gknd 5530 2 public public JJ cord-010119-t1x9gknd 5530 3 health health NN cord-010119-t1x9gknd 5530 4 value value NN cord-010119-t1x9gknd 5530 5 of of IN cord-010119-t1x9gknd 5530 6 PBM PBM NNP cord-010119-t1x9gknd 5530 7 implementation implementation NN cord-010119-t1x9gknd 5530 8 in in IN cord-010119-t1x9gknd 5530 9 Portugal Portugal NNP cord-010119-t1x9gknd 5530 10 derives derive VBZ cord-010119-t1x9gknd 5530 11 from from IN cord-010119-t1x9gknd 5530 12 the the DT cord-010119-t1x9gknd 5530 13 comparison comparison NN cord-010119-t1x9gknd 5530 14 of of IN cord-010119-t1x9gknd 5530 15 two two CD cord-010119-t1x9gknd 5530 16 scenarios scenario NNS cord-010119-t1x9gknd 5530 17 : : : cord-010119-t1x9gknd 5530 18 " " `` cord-010119-t1x9gknd 5530 19 current current JJ cord-010119-t1x9gknd 5530 20 clinical clinical JJ cord-010119-t1x9gknd 5530 21 practice practice NN cord-010119-t1x9gknd 5530 22 " " '' cord-010119-t1x9gknd 5530 23 and and CC cord-010119-t1x9gknd 5530 24 " " '' cord-010119-t1x9gknd 5530 25 with with IN cord-010119-t1x9gknd 5530 26 PBM PBM NNP cord-010119-t1x9gknd 5530 27 implementation implementation NN cord-010119-t1x9gknd 5530 28 " " '' cord-010119-t1x9gknd 5530 29 . . . cord-010119-t1x9gknd 5531 1 Results/ Results/ . cord-010119-t1x9gknd 5532 1 Finding finding NN cord-010119-t1x9gknd 5532 2 : : : cord-010119-t1x9gknd 5532 3 KOL KOL NNP cord-010119-t1x9gknd 5532 4 elicited elicit VBD cord-010119-t1x9gknd 5532 5 iron iron NN cord-010119-t1x9gknd 5532 6 administration administration NN cord-010119-t1x9gknd 5532 7 followed follow VBN cord-010119-t1x9gknd 5532 8 by by IN cord-010119-t1x9gknd 5532 9 restrictive restrictive JJ cord-010119-t1x9gknd 5532 10 transfusion transfusion NN cord-010119-t1x9gknd 5532 11 of of IN cord-010119-t1x9gknd 5532 12 red red JJ cord-010119-t1x9gknd 5532 13 blood blood NN cord-010119-t1x9gknd 5532 14 cell cell NN cord-010119-t1x9gknd 5532 15 as as IN cord-010119-t1x9gknd 5532 16 the the DT cord-010119-t1x9gknd 5532 17 most most RBS cord-010119-t1x9gknd 5532 18 preferred preferred JJ cord-010119-t1x9gknd 5532 19 PBM PBM NNP cord-010119-t1x9gknd 5532 20 strategies strategy NNS cord-010119-t1x9gknd 5532 21 ( ( -LRB- cord-010119-t1x9gknd 5532 22 14.4 14.4 CD cord-010119-t1x9gknd 5532 23 % % NN cord-010119-t1x9gknd 5532 24 and and CC cord-010119-t1x9gknd 5532 25 14.0 14.0 CD cord-010119-t1x9gknd 5532 26 % % NN cord-010119-t1x9gknd 5532 27 ) ) -RRB- cord-010119-t1x9gknd 5532 28 , , , cord-010119-t1x9gknd 5532 29 for for IN cord-010119-t1x9gknd 5532 30 the the DT cord-010119-t1x9gknd 5532 31 remaining remain VBG cord-010119-t1x9gknd 5532 32 strategies strategy NNS cord-010119-t1x9gknd 5532 33 weights weight NNS cord-010119-t1x9gknd 5532 34 varied vary VBN cord-010119-t1x9gknd 5532 35 between between IN cord-010119-t1x9gknd 5532 36 7.0 7.0 CD cord-010119-t1x9gknd 5532 37 % % NN cord-010119-t1x9gknd 5532 38 and and CC cord-010119-t1x9gknd 5532 39 10.6 10.6 CD cord-010119-t1x9gknd 5532 40 % % NN cord-010119-t1x9gknd 5532 41 . . . cord-010119-t1x9gknd 5533 1 We -PRON- PRP cord-010119-t1x9gknd 5533 2 estimate estimate VBP cord-010119-t1x9gknd 5533 3 that that IN cord-010119-t1x9gknd 5533 4 384,704 384,704 CD cord-010119-t1x9gknd 5533 5 patients patient NNS cord-010119-t1x9gknd 5533 6 would would MD cord-010119-t1x9gknd 5533 7 be be VB cord-010119-t1x9gknd 5533 8 eligible eligible JJ cord-010119-t1x9gknd 5533 9 for for IN cord-010119-t1x9gknd 5533 10 PBM PBM NNP cord-010119-t1x9gknd 5533 11 strategies strategy NNS cord-010119-t1x9gknd 5533 12 in in IN cord-010119-t1x9gknd 5533 13 one one CD cord-010119-t1x9gknd 5533 14 year year NN cord-010119-t1x9gknd 5533 15 time time NN cord-010119-t1x9gknd 5533 16 horizon horizon NN cord-010119-t1x9gknd 5533 17 , , , cord-010119-t1x9gknd 5533 18 resulting result VBG cord-010119-t1x9gknd 5533 19 in in IN cord-010119-t1x9gknd 5533 20 594 594 CD cord-010119-t1x9gknd 5533 21 premature premature JJ cord-010119-t1x9gknd 5533 22 death death NN cord-010119-t1x9gknd 5533 23 avoided avoid VBD cord-010119-t1x9gknd 5533 24 ( ( -LRB- cord-010119-t1x9gknd 5533 25 3.8 3.8 CD cord-010119-t1x9gknd 5533 26 % % NN cord-010119-t1x9gknd 5533 27 reduction reduction NN cord-010119-t1x9gknd 5533 28 ) ) -RRB- cord-010119-t1x9gknd 5533 29 corresponding correspond VBG cord-010119-t1x9gknd 5533 30 to to IN cord-010119-t1x9gknd 5533 31 a a DT cord-010119-t1x9gknd 5533 32 gain gain NN cord-010119-t1x9gknd 5533 33 of of IN cord-010119-t1x9gknd 5533 34 approximately approximately RB cord-010119-t1x9gknd 5533 35 1,500 1,500 CD cord-010119-t1x9gknd 5533 36 life life NN cord-010119-t1x9gknd 5533 37 years year NNS cord-010119-t1x9gknd 5533 38 and and CC cord-010119-t1x9gknd 5533 39 a a DT cord-010119-t1x9gknd 5533 40 reduction reduction NN cord-010119-t1x9gknd 5533 41 of of IN cord-010119-t1x9gknd 5533 42 3,660 3,660 CD cord-010119-t1x9gknd 5533 43 ( ( -LRB- cord-010119-t1x9gknd 5533 44 6.0 6.0 CD cord-010119-t1x9gknd 5533 45 % % NN cord-010119-t1x9gknd 5533 46 ) ) -RRB- cord-010119-t1x9gknd 5533 47 disability disability NN cord-010119-t1x9gknd 5533 48 adjusted adjust VBN cord-010119-t1x9gknd 5533 49 life life NN cord-010119-t1x9gknd 5533 50 years year NNS cord-010119-t1x9gknd 5533 51 ( ( -LRB- cord-010119-t1x9gknd 5533 52 DALY DALY NNP cord-010119-t1x9gknd 5533 53 ) ) -RRB- cord-010119-t1x9gknd 5533 54 relative relative JJ cord-010119-t1x9gknd 5533 55 to to IN cord-010119-t1x9gknd 5533 56 the the DT cord-010119-t1x9gknd 5533 57 current current JJ cord-010119-t1x9gknd 5533 58 clinical clinical JJ cord-010119-t1x9gknd 5533 59 practice practice NN cord-010119-t1x9gknd 5533 60 . . . cord-010119-t1x9gknd 5534 1 A a DT cord-010119-t1x9gknd 5534 2 decrease decrease NN cord-010119-t1x9gknd 5534 3 of of IN cord-010119-t1x9gknd 5534 4 233,141 233,141 CD cord-010119-t1x9gknd 5534 5 in in IN cord-010119-t1x9gknd 5534 6 - - HYPH cord-010119-t1x9gknd 5534 7 hospital hospital NN cord-010119-t1x9gknd 5534 8 days day NNS cord-010119-t1x9gknd 5534 9 is be VBZ cord-010119-t1x9gknd 5534 10 expected expect VBN cord-010119-t1x9gknd 5534 11 mainly mainly RB cord-010119-t1x9gknd 5534 12 due due IN cord-010119-t1x9gknd 5534 13 to to IN cord-010119-t1x9gknd 5534 14 a a DT cord-010119-t1x9gknd 5534 15 8.4 8.4 CD cord-010119-t1x9gknd 5534 16 % % NN cord-010119-t1x9gknd 5534 17 reduction reduction NN cord-010119-t1x9gknd 5534 18 in in IN cord-010119-t1x9gknd 5534 19 hospital hospital NN cord-010119-t1x9gknd 5534 20 length length NN cord-010119-t1x9gknd 5534 21 of of IN cord-010119-t1x9gknd 5534 22 stay stay NN cord-010119-t1x9gknd 5534 23 and and CC cord-010119-t1x9gknd 5534 24 a a DT cord-010119-t1x9gknd 5534 25 37.3 37.3 CD cord-010119-t1x9gknd 5534 26 % % NN cord-010119-t1x9gknd 5534 27 reduction reduction NN cord-010119-t1x9gknd 5534 28 in in IN cord-010119-t1x9gknd 5534 29 30-day 30-day CD cord-010119-t1x9gknd 5534 30 readmission readmission NN cord-010119-t1x9gknd 5534 31 rate rate NN cord-010119-t1x9gknd 5534 32 . . . cord-010119-t1x9gknd 5535 1 In in IN cord-010119-t1x9gknd 5535 2 this this DT cord-010119-t1x9gknd 5535 3 population population NN cord-010119-t1x9gknd 5535 4 the the DT cord-010119-t1x9gknd 5535 5 overall overall JJ cord-010119-t1x9gknd 5535 6 transfusion transfusion NN cord-010119-t1x9gknd 5535 7 rate rate NN cord-010119-t1x9gknd 5535 8 could could MD cord-010119-t1x9gknd 5535 9 decrease decrease VB cord-010119-t1x9gknd 5535 10 to to IN cord-010119-t1x9gknd 5535 11 4.3 4.3 CD cord-010119-t1x9gknd 5535 12 % % NN cord-010119-t1x9gknd 5535 13 from from IN cord-010119-t1x9gknd 5535 14 the the DT cord-010119-t1x9gknd 5535 15 current current JJ cord-010119-t1x9gknd 5535 16 8.7 8.7 CD cord-010119-t1x9gknd 5535 17 % % NN cord-010119-t1x9gknd 5535 18 ( ( -LRB- cord-010119-t1x9gknd 5535 19 51.2 51.2 CD cord-010119-t1x9gknd 5535 20 % % NN cord-010119-t1x9gknd 5535 21 reduction reduction NN cord-010119-t1x9gknd 5535 22 ) ) -RRB- cord-010119-t1x9gknd 5535 23 implying imply VBG cord-010119-t1x9gknd 5535 24 17,202 17,202 CD cord-010119-t1x9gknd 5535 25 blood blood NN cord-010119-t1x9gknd 5535 26 transfusion transfusion NN cord-010119-t1x9gknd 5535 27 avoided avoid VBN cord-010119-t1x9gknd 5535 28 and and CC cord-010119-t1x9gknd 5535 29 65,214 65,214 CD cord-010119-t1x9gknd 5535 30 red red JJ cord-010119-t1x9gknd 5535 31 blood blood NN cord-010119-t1x9gknd 5535 32 cells cell NNS cord-010119-t1x9gknd 5535 33 units unit NNS cord-010119-t1x9gknd 5535 34 spared spare VBD cord-010119-t1x9gknd 5535 35 . . . cord-010119-t1x9gknd 5536 1 Conclusion conclusion NN cord-010119-t1x9gknd 5536 2 : : : cord-010119-t1x9gknd 5537 1 We -PRON- PRP cord-010119-t1x9gknd 5537 2 anticipate anticipate VBP cord-010119-t1x9gknd 5537 3 that that IN cord-010119-t1x9gknd 5537 4 the the DT cord-010119-t1x9gknd 5537 5 implementation implementation NN cord-010119-t1x9gknd 5537 6 of of IN cord-010119-t1x9gknd 5537 7 a a DT cord-010119-t1x9gknd 5537 8 nationwide nationwide JJ cord-010119-t1x9gknd 5537 9 patient patient JJ cord-010119-t1x9gknd 5537 10 blood blood NN cord-010119-t1x9gknd 5537 11 management management NN cord-010119-t1x9gknd 5537 12 program program NN cord-010119-t1x9gknd 5537 13 will will MD cord-010119-t1x9gknd 5537 14 represent represent VB cord-010119-t1x9gknd 5537 15 a a DT cord-010119-t1x9gknd 5537 16 paramount paramount JJ cord-010119-t1x9gknd 5537 17 improvement improvement NN cord-010119-t1x9gknd 5537 18 in in IN cord-010119-t1x9gknd 5537 19 clinical clinical JJ cord-010119-t1x9gknd 5537 20 outcomes outcome NNS cord-010119-t1x9gknd 5537 21 in in IN cord-010119-t1x9gknd 5537 22 terms term NNS cord-010119-t1x9gknd 5537 23 of of IN cord-010119-t1x9gknd 5537 24 morbidity morbidity NN cord-010119-t1x9gknd 5537 25 and and CC cord-010119-t1x9gknd 5537 26 mortality mortality NN cord-010119-t1x9gknd 5537 27 and and CC cord-010119-t1x9gknd 5537 28 may may MD cord-010119-t1x9gknd 5537 29 have have VB cord-010119-t1x9gknd 5537 30 a a DT cord-010119-t1x9gknd 5537 31 substantial substantial JJ cord-010119-t1x9gknd 5537 32 public public JJ cord-010119-t1x9gknd 5537 33 health health NN cord-010119-t1x9gknd 5537 34 impact impact NN cord-010119-t1x9gknd 5537 35 while while IN cord-010119-t1x9gknd 5537 36 contributing contribute VBG cord-010119-t1x9gknd 5537 37 a a DT cord-010119-t1x9gknd 5537 38 more more RBR cord-010119-t1x9gknd 5537 39 efficient efficient JJ cord-010119-t1x9gknd 5537 40 use use NN cord-010119-t1x9gknd 5537 41 health health NN cord-010119-t1x9gknd 5537 42 resources resource NNS cord-010119-t1x9gknd 5537 43 . . . cord-010119-t1x9gknd 5538 1 Results/ Results/ . cord-010119-t1x9gknd 5539 1 Finding finding NN cord-010119-t1x9gknd 5539 2 : : : cord-010119-t1x9gknd 5539 3 237 237 CD cord-010119-t1x9gknd 5539 4 adult adult NN cord-010119-t1x9gknd 5539 5 liver liver NN cord-010119-t1x9gknd 5539 6 transplants transplant NNS cord-010119-t1x9gknd 5539 7 were be VBD cord-010119-t1x9gknd 5539 8 performed perform VBN cord-010119-t1x9gknd 5539 9 during during IN cord-010119-t1x9gknd 5539 10 the the DT cord-010119-t1x9gknd 5539 11 evaluation evaluation NN cord-010119-t1x9gknd 5539 12 period period NN cord-010119-t1x9gknd 5539 13 . . . cord-010119-t1x9gknd 5540 1 Preoperative preoperative JJ cord-010119-t1x9gknd 5540 2 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5540 3 , , , cord-010119-t1x9gknd 5540 4 creatinine creatinine NN cord-010119-t1x9gknd 5540 5 , , , cord-010119-t1x9gknd 5540 6 MELD meld VB cord-010119-t1x9gknd 5540 7 score score NN cord-010119-t1x9gknd 5540 8 , , , cord-010119-t1x9gknd 5540 9 spontaneous spontaneous JJ cord-010119-t1x9gknd 5540 10 bacterial bacterial JJ cord-010119-t1x9gknd 5540 11 peritonitis peritonitis NN cord-010119-t1x9gknd 5540 12 ( ( -LRB- cord-010119-t1x9gknd 5540 13 SBP SBP NNP cord-010119-t1x9gknd 5540 14 ) ) -RRB- cord-010119-t1x9gknd 5540 15 , , , cord-010119-t1x9gknd 5540 16 preoperative preoperative JJ cord-010119-t1x9gknd 5540 17 hemodialysis hemodialysis NN cord-010119-t1x9gknd 5540 18 , , , cord-010119-t1x9gknd 5540 19 gender gender NN cord-010119-t1x9gknd 5540 20 , , , cord-010119-t1x9gknd 5540 21 and and CC cord-010119-t1x9gknd 5540 22 portal portal JJ cord-010119-t1x9gknd 5540 23 vein vein NN cord-010119-t1x9gknd 5540 24 thrombosis thrombosis NNP cord-010119-t1x9gknd 5540 25 ( ( -LRB- cord-010119-t1x9gknd 5540 26 PVT PVT NNP cord-010119-t1x9gknd 5540 27 ) ) -RRB- cord-010119-t1x9gknd 5540 28 gave give VBD cord-010119-t1x9gknd 5540 29 the the DT cord-010119-t1x9gknd 5540 30 strongest strong JJS cord-010119-t1x9gknd 5540 31 model model NN cord-010119-t1x9gknd 5540 32 predicting predict VBG cord-010119-t1x9gknd 5540 33 RBC RBC NNP cord-010119-t1x9gknd 5540 34 usage usage NN cord-010119-t1x9gknd 5540 35 . . . cord-010119-t1x9gknd 5541 1 If if IN cord-010119-t1x9gknd 5541 2 the the DT cord-010119-t1x9gknd 5541 3 model model NN cord-010119-t1x9gknd 5541 4 predicted predict VBD cord-010119-t1x9gknd 5541 5 < < NNP cord-010119-t1x9gknd 5541 6 1250ml 1250ml NN cord-010119-t1x9gknd 5541 7 of of IN cord-010119-t1x9gknd 5541 8 RBCs rbc NNS cord-010119-t1x9gknd 5541 9 , , , cord-010119-t1x9gknd 5541 10 all all DT cord-010119-t1x9gknd 5541 11 cases case NNS cord-010119-t1x9gknd 5541 12 with with IN cord-010119-t1x9gknd 5541 13 0ml 0ml JJ cord-010119-t1x9gknd 5541 14 transfused transfuse VBN cord-010119-t1x9gknd 5541 15 were be VBD cord-010119-t1x9gknd 5541 16 captured capture VBN cord-010119-t1x9gknd 5541 17 and and CC cord-010119-t1x9gknd 5541 18 only only RB cord-010119-t1x9gknd 5541 19 7.8 7.8 CD cord-010119-t1x9gknd 5541 20 % % NN cord-010119-t1x9gknd 5541 21 of of IN cord-010119-t1x9gknd 5541 22 the the DT cord-010119-t1x9gknd 5541 23 time time NN cord-010119-t1x9gknd 5541 24 > > XX cord-010119-t1x9gknd 5541 25 1250ml 1250ml CD cord-010119-t1x9gknd 5541 26 were be VBD cord-010119-t1x9gknd 5541 27 used use VBN cord-010119-t1x9gknd 5541 28 . . . cord-010119-t1x9gknd 5542 1 If if IN cord-010119-t1x9gknd 5542 2 1250 1250 CD cord-010119-t1x9gknd 5542 3 - - HYPH cord-010119-t1x9gknd 5542 4 2000ml 2000ml JJ cord-010119-t1x9gknd 5542 5 RBCs rbc NNS cord-010119-t1x9gknd 5542 6 were be VBD cord-010119-t1x9gknd 5542 7 predicted predict VBN cord-010119-t1x9gknd 5542 8 to to TO cord-010119-t1x9gknd 5542 9 be be VB cord-010119-t1x9gknd 5542 10 transfused transfuse VBN cord-010119-t1x9gknd 5542 11 , , , cord-010119-t1x9gknd 5542 12 > > XX cord-010119-t1x9gknd 5543 1 2000ml 2000ml NNP cord-010119-t1x9gknd 5543 2 were be VBD cord-010119-t1x9gknd 5543 3 used use VBN cord-010119-t1x9gknd 5543 4 25 25 CD cord-010119-t1x9gknd 5543 5 % % NN cord-010119-t1x9gknd 5543 6 of of IN cord-010119-t1x9gknd 5543 7 the the DT cord-010119-t1x9gknd 5543 8 time time NN cord-010119-t1x9gknd 5543 9 . . . cord-010119-t1x9gknd 5544 1 If if IN cord-010119-t1x9gknd 5544 2 predicted predict VBN cord-010119-t1x9gknd 5544 3 usage usage NN cord-010119-t1x9gknd 5544 4 was be VBD cord-010119-t1x9gknd 5544 5 > > XX cord-010119-t1x9gknd 5544 6 2000ml 2000ml NN cord-010119-t1x9gknd 5544 7 , , , cord-010119-t1x9gknd 5544 8 53 53 CD cord-010119-t1x9gknd 5544 9 % % NN cord-010119-t1x9gknd 5544 10 of of IN cord-010119-t1x9gknd 5544 11 the the DT cord-010119-t1x9gknd 5544 12 time time NN cord-010119-t1x9gknd 5544 13 it -PRON- PRP cord-010119-t1x9gknd 5544 14 exceeded exceed VBD cord-010119-t1x9gknd 5544 15 2000ml 2000ml RB cord-010119-t1x9gknd 5544 16 . . . cord-010119-t1x9gknd 5545 1 Conclusion conclusion NN cord-010119-t1x9gknd 5545 2 : : : cord-010119-t1x9gknd 5546 1 A a DT cord-010119-t1x9gknd 5546 2 model model NN cord-010119-t1x9gknd 5546 3 using use VBG cord-010119-t1x9gknd 5546 4 specific specific JJ cord-010119-t1x9gknd 5546 5 preoperative preoperative JJ cord-010119-t1x9gknd 5546 6 factors factor NNS cord-010119-t1x9gknd 5546 7 can can MD cord-010119-t1x9gknd 5546 8 be be VB cord-010119-t1x9gknd 5546 9 used use VBN cord-010119-t1x9gknd 5546 10 to to TO cord-010119-t1x9gknd 5546 11 predict predict VB cord-010119-t1x9gknd 5546 12 intraoperative intraoperative JJ cord-010119-t1x9gknd 5546 13 RBC RBC NNP cord-010119-t1x9gknd 5546 14 usage usage NN cord-010119-t1x9gknd 5546 15 . . . cord-010119-t1x9gknd 5547 1 Patients patient NNS cord-010119-t1x9gknd 5547 2 at at IN cord-010119-t1x9gknd 5547 3 risk risk NN cord-010119-t1x9gknd 5547 4 for for IN cord-010119-t1x9gknd 5547 5 > > XX cord-010119-t1x9gknd 5548 1 1250ml 1250ml NN cord-010119-t1x9gknd 5548 2 of of IN cord-010119-t1x9gknd 5548 3 RBC RBC NNP cord-010119-t1x9gknd 5548 4 transfusion transfusion NN cord-010119-t1x9gknd 5548 5 can can MD cord-010119-t1x9gknd 5548 6 be be VB cord-010119-t1x9gknd 5548 7 identified identify VBN cord-010119-t1x9gknd 5548 8 with with IN cord-010119-t1x9gknd 5548 9 reasonable reasonable JJ cord-010119-t1x9gknd 5548 10 accuracy accuracy NN cord-010119-t1x9gknd 5548 11 using use VBG cord-010119-t1x9gknd 5548 12 this this DT cord-010119-t1x9gknd 5548 13 model model NN cord-010119-t1x9gknd 5548 14 at at IN cord-010119-t1x9gknd 5548 15 our -PRON- PRP$ cord-010119-t1x9gknd 5548 16 institution institution NN cord-010119-t1x9gknd 5548 17 . . . cord-010119-t1x9gknd 5549 1 Use use NN cord-010119-t1x9gknd 5549 2 of of IN cord-010119-t1x9gknd 5549 3 this this DT cord-010119-t1x9gknd 5549 4 model model NN cord-010119-t1x9gknd 5549 5 might may MD cord-010119-t1x9gknd 5549 6 help help VB cord-010119-t1x9gknd 5549 7 improve improve VB cord-010119-t1x9gknd 5549 8 preparation preparation NN cord-010119-t1x9gknd 5549 9 and and CC cord-010119-t1x9gknd 5549 10 utilization utilization NN cord-010119-t1x9gknd 5549 11 of of IN cord-010119-t1x9gknd 5549 12 the the DT cord-010119-t1x9gknd 5549 13 blood blood NN cord-010119-t1x9gknd 5549 14 bank bank NN cord-010119-t1x9gknd 5549 15 . . . cord-010119-t1x9gknd 5550 1 Review Review NNP cord-010119-t1x9gknd 5550 2 of of IN cord-010119-t1x9gknd 5550 3 Blood Blood NNP cord-010119-t1x9gknd 5550 4 Ordering Ordering NNP cord-010119-t1x9gknd 5550 5 Practice Practice NNP cord-010119-t1x9gknd 5550 6 for for IN cord-010119-t1x9gknd 5550 7 Elective Elective NNP cord-010119-t1x9gknd 5550 8 Surgeries Surgeries NNPS cord-010119-t1x9gknd 5550 9 in in IN cord-010119-t1x9gknd 5550 10 a a DT cord-010119-t1x9gknd 5550 11 Maternity Maternity NNP cord-010119-t1x9gknd 5550 12 Hospital Hospital NNP cord-010119-t1x9gknd 5550 13 Qi Qi NNP cord-010119-t1x9gknd 5550 14 Raymond Raymond NNP cord-010119-t1x9gknd 5550 15 Fu Fu NNP cord-010119-t1x9gknd 5551 1 * * NFP cord-010119-t1x9gknd 5551 2 . . . cord-010119-t1x9gknd 5552 1 KK KK NNP cord-010119-t1x9gknd 5552 2 Women Women NNP cord-010119-t1x9gknd 5552 3 's 's POS cord-010119-t1x9gknd 5552 4 and and CC cord-010119-t1x9gknd 5552 5 Children Children NNP cord-010119-t1x9gknd 5552 6 's 's POS cord-010119-t1x9gknd 5552 7 Hospital Hospital NNP cord-010119-t1x9gknd 5552 8 Background Background NNP cord-010119-t1x9gknd 5552 9 / / SYM cord-010119-t1x9gknd 5552 10 Case Case NNP cord-010119-t1x9gknd 5552 11 Studies Studies NNPS cord-010119-t1x9gknd 5552 12 : : : cord-010119-t1x9gknd 5553 1 Pre pre JJ cord-010119-t1x9gknd 5553 2 - - JJ cord-010119-t1x9gknd 5553 3 operative operative JJ cord-010119-t1x9gknd 5553 4 over over NN cord-010119-t1x9gknd 5553 5 - - HYPH cord-010119-t1x9gknd 5553 6 ordering ordering NN cord-010119-t1x9gknd 5553 7 of of IN cord-010119-t1x9gknd 5553 8 blood blood NN cord-010119-t1x9gknd 5553 9 is be VBZ cord-010119-t1x9gknd 5553 10 common common JJ cord-010119-t1x9gknd 5553 11 , , , cord-010119-t1x9gknd 5553 12 resulting result VBG cord-010119-t1x9gknd 5553 13 in in IN cord-010119-t1x9gknd 5553 14 waste waste NN cord-010119-t1x9gknd 5553 15 of of IN cord-010119-t1x9gknd 5553 16 blood blood NN cord-010119-t1x9gknd 5553 17 bank bank NN cord-010119-t1x9gknd 5553 18 resources resource NNS cord-010119-t1x9gknd 5553 19 . . . cord-010119-t1x9gknd 5554 1 Blood blood NN cord-010119-t1x9gknd 5554 2 units unit NNS cord-010119-t1x9gknd 5554 3 are be VBP cord-010119-t1x9gknd 5554 4 withdrawn withdraw VBN cord-010119-t1x9gknd 5554 5 from from IN cord-010119-t1x9gknd 5554 6 the the DT cord-010119-t1x9gknd 5554 7 pool pool NN cord-010119-t1x9gknd 5554 8 , , , cord-010119-t1x9gknd 5554 9 leading lead VBG cord-010119-t1x9gknd 5554 10 to to IN cord-010119-t1x9gknd 5554 11 constraints constraint NNS cord-010119-t1x9gknd 5554 12 in in IN cord-010119-t1x9gknd 5554 13 allocating allocate VBG cord-010119-t1x9gknd 5554 14 the the DT cord-010119-t1x9gknd 5554 15 limited limited JJ cord-010119-t1x9gknd 5554 16 blood blood NN cord-010119-t1x9gknd 5554 17 resources resource NNS cord-010119-t1x9gknd 5554 18 to to TO cord-010119-t1x9gknd 5554 19 meet meet VB cord-010119-t1x9gknd 5554 20 the the DT cord-010119-t1x9gknd 5554 21 needs need NNS cord-010119-t1x9gknd 5554 22 of of IN cord-010119-t1x9gknd 5554 23 other other JJ cord-010119-t1x9gknd 5554 24 patients patient NNS cord-010119-t1x9gknd 5554 25 . . . cord-010119-t1x9gknd 5555 1 The the DT cord-010119-t1x9gknd 5555 2 Cross Cross NNP cord-010119-t1x9gknd 5555 3 - - NN cord-010119-t1x9gknd 5555 4 match match NN cord-010119-t1x9gknd 5555 5 to to IN cord-010119-t1x9gknd 5555 6 Transfusion Transfusion NNP cord-010119-t1x9gknd 5555 7 ( ( -LRB- cord-010119-t1x9gknd 5555 8 CT CT NNP cord-010119-t1x9gknd 5555 9 ) ) -RRB- cord-010119-t1x9gknd 5555 10 ratio ratio NN cord-010119-t1x9gknd 5555 11 is be VBZ cord-010119-t1x9gknd 5555 12 often often RB cord-010119-t1x9gknd 5555 13 used use VBN cord-010119-t1x9gknd 5555 14 in in IN cord-010119-t1x9gknd 5555 15 benchmarking benchmarke VBG cord-010119-t1x9gknd 5555 16 efficient efficient JJ cord-010119-t1x9gknd 5555 17 blood blood NN cord-010119-t1x9gknd 5555 18 utilization utilization NN cord-010119-t1x9gknd 5555 19 within within IN cord-010119-t1x9gknd 5555 20 the the DT cord-010119-t1x9gknd 5555 21 hospital hospital NN cord-010119-t1x9gknd 5555 22 blood blood NN cord-010119-t1x9gknd 5555 23 transfusion transfusion NN cord-010119-t1x9gknd 5555 24 service service NN cord-010119-t1x9gknd 5555 25 . . . cord-010119-t1x9gknd 5556 1 According accord VBG cord-010119-t1x9gknd 5556 2 to to IN cord-010119-t1x9gknd 5556 3 the the DT cord-010119-t1x9gknd 5556 4 American American NNP cord-010119-t1x9gknd 5556 5 Association Association NNP cord-010119-t1x9gknd 5556 6 of of IN cord-010119-t1x9gknd 5556 7 Blood Blood NNP cord-010119-t1x9gknd 5556 8 Banks Banks NNPS cord-010119-t1x9gknd 5556 9 ( ( -LRB- cord-010119-t1x9gknd 5556 10 AABB AABB NNP cord-010119-t1x9gknd 5556 11 ) ) -RRB- cord-010119-t1x9gknd 5556 12 , , , cord-010119-t1x9gknd 5556 13 a a DT cord-010119-t1x9gknd 5556 14 CT CT NNP cord-010119-t1x9gknd 5556 15 ratio ratio NN cord-010119-t1x9gknd 5556 16 of of IN cord-010119-t1x9gknd 5556 17 less less JJR cord-010119-t1x9gknd 5556 18 than than IN cord-010119-t1x9gknd 5556 19 2.0 2.0 CD cord-010119-t1x9gknd 5556 20 is be VBZ cord-010119-t1x9gknd 5556 21 favorable favorable JJ cord-010119-t1x9gknd 5556 22 , , , cord-010119-t1x9gknd 5556 23 and and CC cord-010119-t1x9gknd 5556 24 anything anything NN cord-010119-t1x9gknd 5556 25 above above RB cord-010119-t1x9gknd 5556 26 indicates indicate VBZ cord-010119-t1x9gknd 5556 27 over over RB cord-010119-t1x9gknd 5556 28 - - HYPH cord-010119-t1x9gknd 5556 29 ordering ordering NN cord-010119-t1x9gknd 5556 30 and and CC cord-010119-t1x9gknd 5556 31 cross cross NN cord-010119-t1x9gknd 5556 32 - - NN cord-010119-t1x9gknd 5556 33 matching matching NN cord-010119-t1x9gknd 5556 34 of of IN cord-010119-t1x9gknd 5556 35 blood blood NN cord-010119-t1x9gknd 5556 36 . . . cord-010119-t1x9gknd 5557 1 To to TO cord-010119-t1x9gknd 5557 2 achieve achieve VB cord-010119-t1x9gknd 5557 3 this this DT cord-010119-t1x9gknd 5557 4 , , , cord-010119-t1x9gknd 5557 5 it -PRON- PRP cord-010119-t1x9gknd 5557 6 is be VBZ cord-010119-t1x9gknd 5557 7 necessary necessary JJ cord-010119-t1x9gknd 5557 8 to to TO cord-010119-t1x9gknd 5557 9 review review VB cord-010119-t1x9gknd 5557 10 pre pre JJ cord-010119-t1x9gknd 5557 11 - - JJ cord-010119-t1x9gknd 5557 12 surgical surgical JJ cord-010119-t1x9gknd 5557 13 blood blood NN cord-010119-t1x9gknd 5557 14 ordering ordering NN cord-010119-t1x9gknd 5557 15 practice practice NN cord-010119-t1x9gknd 5557 16 in in IN cord-010119-t1x9gknd 5557 17 a a DT cord-010119-t1x9gknd 5557 18 maternity maternity NN cord-010119-t1x9gknd 5557 19 hospital hospital NN cord-010119-t1x9gknd 5557 20 . . . cord-010119-t1x9gknd 5558 1 Study Study NNP cord-010119-t1x9gknd 5558 2 Design Design NNP cord-010119-t1x9gknd 5558 3 / / SYM cord-010119-t1x9gknd 5558 4 Methods method NNS cord-010119-t1x9gknd 5558 5 : : : cord-010119-t1x9gknd 5559 1 Data datum NNS cord-010119-t1x9gknd 5559 2 on on IN cord-010119-t1x9gknd 5559 3 elective elective JJ cord-010119-t1x9gknd 5559 4 surgeries surgery NNS cord-010119-t1x9gknd 5559 5 requiring require VBG cord-010119-t1x9gknd 5559 6 blood blood NN cord-010119-t1x9gknd 5559 7 for for IN cord-010119-t1x9gknd 5559 8 standby standby NN cord-010119-t1x9gknd 5559 9 was be VBD cord-010119-t1x9gknd 5559 10 collected collect VBN cord-010119-t1x9gknd 5559 11 retrospectively retrospectively RB cord-010119-t1x9gknd 5559 12 over over IN cord-010119-t1x9gknd 5559 13 a a DT cord-010119-t1x9gknd 5559 14 3 3 CD cord-010119-t1x9gknd 5559 15 month month NN cord-010119-t1x9gknd 5559 16 period period NN cord-010119-t1x9gknd 5559 17 ( ( -LRB- cord-010119-t1x9gknd 5559 18 Jan Jan NNP cord-010119-t1x9gknd 5559 19 to to IN cord-010119-t1x9gknd 5559 20 Mar Mar NNP cord-010119-t1x9gknd 5559 21 2017 2017 CD cord-010119-t1x9gknd 5559 22 ) ) -RRB- cord-010119-t1x9gknd 5559 23 . . . cord-010119-t1x9gknd 5560 1 Details detail NNS cord-010119-t1x9gknd 5560 2 of of IN cord-010119-t1x9gknd 5560 3 total total JJ cord-010119-t1x9gknd 5560 4 blood blood NN cord-010119-t1x9gknd 5560 5 cross cross NN cord-010119-t1x9gknd 5560 6 - - VBN cord-010119-t1x9gknd 5560 7 matched match VBN cord-010119-t1x9gknd 5560 8 , , , cord-010119-t1x9gknd 5560 9 issued issue VBN cord-010119-t1x9gknd 5560 10 , , , cord-010119-t1x9gknd 5560 11 transfused transfuse VBN cord-010119-t1x9gknd 5560 12 and and CC cord-010119-t1x9gknd 5560 13 returned return VBD cord-010119-t1x9gknd 5560 14 were be VBD cord-010119-t1x9gknd 5560 15 analyzed analyze VBN cord-010119-t1x9gknd 5560 16 along along IN cord-010119-t1x9gknd 5560 17 with with IN cord-010119-t1x9gknd 5560 18 the the DT cord-010119-t1x9gknd 5560 19 CT CT NNP cord-010119-t1x9gknd 5560 20 ratio ratio NN cord-010119-t1x9gknd 5560 21 . . . cord-010119-t1x9gknd 5561 1 Results result NNS cord-010119-t1x9gknd 5561 2 / / SYM cord-010119-t1x9gknd 5561 3 Findings finding NNS cord-010119-t1x9gknd 5561 4 : : : cord-010119-t1x9gknd 5562 1 During during IN cord-010119-t1x9gknd 5562 2 the the DT cord-010119-t1x9gknd 5562 3 3 3 CD cord-010119-t1x9gknd 5562 4 month month NN cord-010119-t1x9gknd 5562 5 period period NN cord-010119-t1x9gknd 5562 6 , , , cord-010119-t1x9gknd 5562 7 there there EX cord-010119-t1x9gknd 5562 8 were be VBD cord-010119-t1x9gknd 5562 9 274 274 CD cord-010119-t1x9gknd 5562 10 patients patient NNS cord-010119-t1x9gknd 5562 11 undergoing undergo VBG cord-010119-t1x9gknd 5562 12 obstetrics obstetric NNS cord-010119-t1x9gknd 5562 13 and and CC cord-010119-t1x9gknd 5562 14 gynecology gynecology NN cord-010119-t1x9gknd 5562 15 procedures procedure NNS cord-010119-t1x9gknd 5562 16 requiring require VBG cord-010119-t1x9gknd 5562 17 blood blood NN cord-010119-t1x9gknd 5562 18 on on IN cord-010119-t1x9gknd 5562 19 standby standby NN cord-010119-t1x9gknd 5562 20 . . . cord-010119-t1x9gknd 5563 1 A a DT cord-010119-t1x9gknd 5563 2 total total NN cord-010119-t1x9gknd 5563 3 of of IN cord-010119-t1x9gknd 5563 4 494 494 CD cord-010119-t1x9gknd 5563 5 units unit NNS cord-010119-t1x9gknd 5563 6 of of IN cord-010119-t1x9gknd 5563 7 blood blood NN cord-010119-t1x9gknd 5563 8 were be VBD cord-010119-t1x9gknd 5563 9 requested request VBN cord-010119-t1x9gknd 5563 10 . . . cord-010119-t1x9gknd 5564 1 154 154 CD cord-010119-t1x9gknd 5564 2 units unit NNS cord-010119-t1x9gknd 5564 3 were be VBD cord-010119-t1x9gknd 5564 4 crossmatched crossmatche VBN cord-010119-t1x9gknd 5564 5 , , , cord-010119-t1x9gknd 5564 6 of of IN cord-010119-t1x9gknd 5564 7 which which WDT cord-010119-t1x9gknd 5564 8 138 138 CD cord-010119-t1x9gknd 5564 9 units unit NNS cord-010119-t1x9gknd 5564 10 were be VBD cord-010119-t1x9gknd 5564 11 sent send VBN cord-010119-t1x9gknd 5564 12 to to IN cord-010119-t1x9gknd 5564 13 the the DT cord-010119-t1x9gknd 5564 14 Operating Operating NNP cord-010119-t1x9gknd 5564 15 Theatre Theatre NNP cord-010119-t1x9gknd 5564 16 ( ( -LRB- cord-010119-t1x9gknd 5564 17 OT OT NNP cord-010119-t1x9gknd 5564 18 ) ) -RRB- cord-010119-t1x9gknd 5564 19 . . . cord-010119-t1x9gknd 5565 1 Only only RB cord-010119-t1x9gknd 5565 2 33.3 33.3 CD cord-010119-t1x9gknd 5565 3 % % NN cord-010119-t1x9gknd 5565 4 of of IN cord-010119-t1x9gknd 5565 5 blood blood NN cord-010119-t1x9gknd 5565 6 issued issue VBN cord-010119-t1x9gknd 5565 7 to to IN cord-010119-t1x9gknd 5565 8 OT OT NNP cord-010119-t1x9gknd 5565 9 were be VBD cord-010119-t1x9gknd 5565 10 transfused transfuse VBN cord-010119-t1x9gknd 5565 11 ( ( -LRB- cord-010119-t1x9gknd 5565 12 n546 n546 NN cord-010119-t1x9gknd 5565 13 ) ) -RRB- cord-010119-t1x9gknd 5565 14 while while IN cord-010119-t1x9gknd 5565 15 the the DT cord-010119-t1x9gknd 5565 16 rest rest NN cord-010119-t1x9gknd 5565 17 were be VBD cord-010119-t1x9gknd 5565 18 unutilized unutilized JJ cord-010119-t1x9gknd 5565 19 . . . cord-010119-t1x9gknd 5566 1 The the DT cord-010119-t1x9gknd 5566 2 observed observed JJ cord-010119-t1x9gknd 5566 3 CT CT NNP cord-010119-t1x9gknd 5566 4 ratio ratio NN cord-010119-t1x9gknd 5566 5 was be VBD cord-010119-t1x9gknd 5566 6 3.35 3.35 CD cord-010119-t1x9gknd 5566 7 . . . cord-010119-t1x9gknd 5567 1 Conclusion conclusion NN cord-010119-t1x9gknd 5567 2 : : : cord-010119-t1x9gknd 5568 1 Although although IN cord-010119-t1x9gknd 5568 2 only only RB cord-010119-t1x9gknd 5568 3 31 31 CD cord-010119-t1x9gknd 5568 4 % % NN cord-010119-t1x9gknd 5568 5 of of IN cord-010119-t1x9gknd 5568 6 total total JJ cord-010119-t1x9gknd 5568 7 blood blood NN cord-010119-t1x9gknd 5568 8 requested request VBD cord-010119-t1x9gknd 5568 9 was be VBD cord-010119-t1x9gknd 5568 10 crossmatched crossmatche VBN cord-010119-t1x9gknd 5568 11 , , , cord-010119-t1x9gknd 5568 12 the the DT cord-010119-t1x9gknd 5568 13 CT CT NNP cord-010119-t1x9gknd 5568 14 ratio ratio NN cord-010119-t1x9gknd 5568 15 remains remain VBZ cord-010119-t1x9gknd 5568 16 above above IN cord-010119-t1x9gknd 5568 17 the the DT cord-010119-t1x9gknd 5568 18 recommended recommend VBN cord-010119-t1x9gknd 5568 19 guideline guideline NN cord-010119-t1x9gknd 5568 20 of of IN cord-010119-t1x9gknd 5568 21 ! ! . cord-010119-t1x9gknd 5569 1 2.0 2.0 CD cord-010119-t1x9gknd 5569 2 , , , cord-010119-t1x9gknd 5569 3 with with IN cord-010119-t1x9gknd 5569 4 almost almost RB cord-010119-t1x9gknd 5569 5 70 70 CD cord-010119-t1x9gknd 5569 6 % % NN cord-010119-t1x9gknd 5569 7 of of IN cord-010119-t1x9gknd 5569 8 cross cross JJ cord-010119-t1x9gknd 5569 9 - - JJ cord-010119-t1x9gknd 5569 10 matched match VBN cord-010119-t1x9gknd 5569 11 blood blood NN cord-010119-t1x9gknd 5569 12 unutilized unutilized JJ cord-010119-t1x9gknd 5569 13 . . . cord-010119-t1x9gknd 5570 1 There there EX cord-010119-t1x9gknd 5570 2 is be VBZ cord-010119-t1x9gknd 5570 3 a a DT cord-010119-t1x9gknd 5570 4 need need NN cord-010119-t1x9gknd 5570 5 to to TO cord-010119-t1x9gknd 5570 6 improve improve VB cord-010119-t1x9gknd 5570 7 and and CC cord-010119-t1x9gknd 5570 8 standardize standardize VB cord-010119-t1x9gknd 5570 9 the the DT cord-010119-t1x9gknd 5570 10 blood blood NN cord-010119-t1x9gknd 5570 11 ordering ordering NN cord-010119-t1x9gknd 5570 12 practice practice NN cord-010119-t1x9gknd 5570 13 to to TO cord-010119-t1x9gknd 5570 14 achieve achieve VB cord-010119-t1x9gknd 5570 15 costeffectiveness costeffectiveness NN cord-010119-t1x9gknd 5570 16 and and CC cord-010119-t1x9gknd 5570 17 reduce reduce VB cord-010119-t1x9gknd 5570 18 unnecessary unnecessary JJ cord-010119-t1x9gknd 5570 19 workload workload NN cord-010119-t1x9gknd 5570 20 . . . cord-010119-t1x9gknd 5571 1 Establishing establish VBG cord-010119-t1x9gknd 5571 2 and and CC cord-010119-t1x9gknd 5571 3 adhering adhere VBG cord-010119-t1x9gknd 5571 4 to to IN cord-010119-t1x9gknd 5571 5 a a DT cord-010119-t1x9gknd 5571 6 maximum maximum JJ cord-010119-t1x9gknd 5571 7 surgical surgical JJ cord-010119-t1x9gknd 5571 8 blood blood NN cord-010119-t1x9gknd 5571 9 order order NN cord-010119-t1x9gknd 5571 10 schedule schedule NN cord-010119-t1x9gknd 5571 11 ( ( -LRB- cord-010119-t1x9gknd 5571 12 MSBOS MSBOS NNP cord-010119-t1x9gknd 5571 13 ) ) -RRB- cord-010119-t1x9gknd 5571 14 could could MD cord-010119-t1x9gknd 5571 15 help help VB cord-010119-t1x9gknd 5571 16 in in IN cord-010119-t1x9gknd 5571 17 conserving conserve VBG cord-010119-t1x9gknd 5571 18 blood blood NN cord-010119-t1x9gknd 5571 19 and and CC cord-010119-t1x9gknd 5571 20 prevent prevent VB cord-010119-t1x9gknd 5571 21 over over RB cord-010119-t1x9gknd 5571 22 - - HYPH cord-010119-t1x9gknd 5571 23 ordering ordering NN cord-010119-t1x9gknd 5571 24 of of IN cord-010119-t1x9gknd 5571 25 blood blood NN cord-010119-t1x9gknd 5571 26 . . . cord-010119-t1x9gknd 5572 1 Background Background NNP cord-010119-t1x9gknd 5572 2 / / SYM cord-010119-t1x9gknd 5572 3 Case Case NNP cord-010119-t1x9gknd 5572 4 Studies Studies NNPS cord-010119-t1x9gknd 5572 5 : : : cord-010119-t1x9gknd 5572 6 Total total JJ cord-010119-t1x9gknd 5572 7 knee knee NN cord-010119-t1x9gknd 5572 8 arthroplasty arthroplasty NN cord-010119-t1x9gknd 5572 9 ( ( -LRB- cord-010119-t1x9gknd 5572 10 TKA TKA NNP cord-010119-t1x9gknd 5572 11 ) ) -RRB- cord-010119-t1x9gknd 5572 12 is be VBZ cord-010119-t1x9gknd 5572 13 a a DT cord-010119-t1x9gknd 5572 14 major major JJ cord-010119-t1x9gknd 5572 15 orthopaedic orthopaedic JJ cord-010119-t1x9gknd 5572 16 procedure procedure NN cord-010119-t1x9gknd 5572 17 with with IN cord-010119-t1x9gknd 5572 18 increased increase VBN cord-010119-t1x9gknd 5572 19 perioperative perioperative JJ cord-010119-t1x9gknd 5572 20 blood blood NN cord-010119-t1x9gknd 5572 21 loss loss NN cord-010119-t1x9gknd 5572 22 . . . cord-010119-t1x9gknd 5573 1 This this DT cord-010119-t1x9gknd 5573 2 perioperative perioperative JJ cord-010119-t1x9gknd 5573 3 blood blood NN cord-010119-t1x9gknd 5573 4 loss loss NN cord-010119-t1x9gknd 5573 5 could could MD cord-010119-t1x9gknd 5573 6 be be VB cord-010119-t1x9gknd 5573 7 more more RBR cord-010119-t1x9gknd 5573 8 significant significant JJ cord-010119-t1x9gknd 5573 9 in in IN cord-010119-t1x9gknd 5573 10 patients patient NNS cord-010119-t1x9gknd 5573 11 undergoing undergo VBG cord-010119-t1x9gknd 5573 12 bilateral bilateral JJ cord-010119-t1x9gknd 5573 13 TKA TKA NNP cord-010119-t1x9gknd 5573 14 in in IN cord-010119-t1x9gknd 5573 15 a a DT cord-010119-t1x9gknd 5573 16 single single JJ cord-010119-t1x9gknd 5573 17 stage stage NN cord-010119-t1x9gknd 5573 18 . . . cord-010119-t1x9gknd 5574 1 The the DT cord-010119-t1x9gknd 5574 2 increased increase VBN cord-010119-t1x9gknd 5574 3 blood blood NN cord-010119-t1x9gknd 5574 4 loss loss NN cord-010119-t1x9gknd 5574 5 in in IN cord-010119-t1x9gknd 5574 6 bilateral bilateral JJ cord-010119-t1x9gknd 5574 7 TKA TKA NNP cord-010119-t1x9gknd 5574 8 often often RB cord-010119-t1x9gknd 5574 9 requires require VBZ cord-010119-t1x9gknd 5574 10 blood blood NN cord-010119-t1x9gknd 5574 11 transfusion transfusion NN cord-010119-t1x9gknd 5574 12 which which WDT cord-010119-t1x9gknd 5574 13 results result VBZ cord-010119-t1x9gknd 5574 14 in in IN cord-010119-t1x9gknd 5574 15 high high JJ cord-010119-t1x9gknd 5574 16 post post JJ cord-010119-t1x9gknd 5574 17 - - JJ cord-010119-t1x9gknd 5574 18 operative operative JJ cord-010119-t1x9gknd 5574 19 morbidities morbidity NNS cord-010119-t1x9gknd 5574 20 . . . cord-010119-t1x9gknd 5575 1 Study Study NNP cord-010119-t1x9gknd 5575 2 Design Design NNP cord-010119-t1x9gknd 5575 3 / / SYM cord-010119-t1x9gknd 5575 4 Methods method NNS cord-010119-t1x9gknd 5575 5 : : : cord-010119-t1x9gknd 5575 6 In in IN cord-010119-t1x9gknd 5575 7 this this DT cord-010119-t1x9gknd 5575 8 retrospective retrospective JJ cord-010119-t1x9gknd 5575 9 study study NN cord-010119-t1x9gknd 5575 10 35 35 CD cord-010119-t1x9gknd 5575 11 patients patient NNS cord-010119-t1x9gknd 5575 12 who who WP cord-010119-t1x9gknd 5575 13 received receive VBD cord-010119-t1x9gknd 5575 14 tranexamic tranexamic JJ cord-010119-t1x9gknd 5575 15 acid acid NN cord-010119-t1x9gknd 5575 16 ( ( -LRB- cord-010119-t1x9gknd 5575 17 TXA TXA NNP cord-010119-t1x9gknd 5575 18 ) ) -RRB- cord-010119-t1x9gknd 5575 19 ( ( -LRB- cord-010119-t1x9gknd 5575 20 study study NN cord-010119-t1x9gknd 5575 21 group group NN cord-010119-t1x9gknd 5575 22 ) ) -RRB- cord-010119-t1x9gknd 5575 23 and and CC cord-010119-t1x9gknd 5575 24 31 31 CD cord-010119-t1x9gknd 5575 25 patients patient NNS cord-010119-t1x9gknd 5575 26 who who WP cord-010119-t1x9gknd 5575 27 did do VBD cord-010119-t1x9gknd 5575 28 not not RB cord-010119-t1x9gknd 5575 29 receive receive VB cord-010119-t1x9gknd 5575 30 TXA TXA NNP cord-010119-t1x9gknd 5575 31 during during IN cord-010119-t1x9gknd 5575 32 surgery surgery NN cord-010119-t1x9gknd 5575 33 ( ( -LRB- cord-010119-t1x9gknd 5575 34 control control NN cord-010119-t1x9gknd 5575 35 ) ) -RRB- cord-010119-t1x9gknd 5575 36 were be VBD cord-010119-t1x9gknd 5575 37 evaluated evaluate VBN cord-010119-t1x9gknd 5575 38 for for IN cord-010119-t1x9gknd 5575 39 blood blood NN cord-010119-t1x9gknd 5575 40 loss loss NN cord-010119-t1x9gknd 5575 41 and and CC cord-010119-t1x9gknd 5575 42 transfusion transfusion NN cord-010119-t1x9gknd 5575 43 requirement requirement NN cord-010119-t1x9gknd 5575 44 . . . cord-010119-t1x9gknd 5576 1 The the DT cord-010119-t1x9gknd 5576 2 study study NN cord-010119-t1x9gknd 5576 3 group group NN cord-010119-t1x9gknd 5576 4 received receive VBD cord-010119-t1x9gknd 5576 5 a a DT cord-010119-t1x9gknd 5576 6 single single JJ cord-010119-t1x9gknd 5576 7 bolus bolus NN cord-010119-t1x9gknd 5576 8 dose dose NN cord-010119-t1x9gknd 5576 9 of of IN cord-010119-t1x9gknd 5576 10 TXA TXA NNP cord-010119-t1x9gknd 5576 11 1gm 1gm NN cord-010119-t1x9gknd 5576 12 IV IV NNP cord-010119-t1x9gknd 5576 13 before before IN cord-010119-t1x9gknd 5576 14 tourniquet tourniquet NN cord-010119-t1x9gknd 5576 15 deflation deflation NN cord-010119-t1x9gknd 5576 16 on on IN cord-010119-t1x9gknd 5576 17 first first JJ cord-010119-t1x9gknd 5576 18 side side NN cord-010119-t1x9gknd 5576 19 knee knee NN cord-010119-t1x9gknd 5576 20 . . . cord-010119-t1x9gknd 5577 1 Statistical Statistical NNP cord-010119-t1x9gknd 5577 2 Background Background NNP cord-010119-t1x9gknd 5577 3 / / SYM cord-010119-t1x9gknd 5577 4 Case Case NNP cord-010119-t1x9gknd 5577 5 Studies Studies NNPS cord-010119-t1x9gknd 5577 6 : : : cord-010119-t1x9gknd 5578 1 Blood blood NN cord-010119-t1x9gknd 5578 2 product product NN cord-010119-t1x9gknd 5578 3 utilization utilization NN cord-010119-t1x9gknd 5578 4 is be VBZ cord-010119-t1x9gknd 5578 5 an an DT cord-010119-t1x9gknd 5578 6 increasing increase VBG cord-010119-t1x9gknd 5578 7 concern concern NN cord-010119-t1x9gknd 5578 8 for for IN cord-010119-t1x9gknd 5578 9 hospital hospital NN cord-010119-t1x9gknd 5578 10 systems system NNS cord-010119-t1x9gknd 5578 11 attempting attempt VBG cord-010119-t1x9gknd 5578 12 to to TO cord-010119-t1x9gknd 5578 13 reduce reduce VB cord-010119-t1x9gknd 5578 14 transfusion transfusion NN cord-010119-t1x9gknd 5578 15 - - HYPH cord-010119-t1x9gknd 5578 16 associated associate VBN cord-010119-t1x9gknd 5578 17 risks risk NNS cord-010119-t1x9gknd 5578 18 . . . cord-010119-t1x9gknd 5579 1 One one CD cord-010119-t1x9gknd 5579 2 strategy strategy NN cord-010119-t1x9gknd 5579 3 to to TO cord-010119-t1x9gknd 5579 4 optimize optimize VB cord-010119-t1x9gknd 5579 5 utilization utilization NN cord-010119-t1x9gknd 5579 6 is be VBZ cord-010119-t1x9gknd 5579 7 to to TO cord-010119-t1x9gknd 5579 8 employ employ VB cord-010119-t1x9gknd 5579 9 clinical clinical JJ cord-010119-t1x9gknd 5579 10 decision decision NN cord-010119-t1x9gknd 5579 11 support support NN cord-010119-t1x9gknd 5579 12 in in IN cord-010119-t1x9gknd 5579 13 the the DT cord-010119-t1x9gknd 5579 14 form form NN cord-010119-t1x9gknd 5579 15 of of IN cord-010119-t1x9gknd 5579 16 alerts alert NNS cord-010119-t1x9gknd 5579 17 to to IN cord-010119-t1x9gknd 5579 18 clinicians clinician NNS cord-010119-t1x9gknd 5579 19 ordering order VBG cord-010119-t1x9gknd 5579 20 blood blood NN cord-010119-t1x9gknd 5579 21 products product NNS cord-010119-t1x9gknd 5579 22 . . . cord-010119-t1x9gknd 5580 1 We -PRON- PRP cord-010119-t1x9gknd 5580 2 investigated investigate VBD cord-010119-t1x9gknd 5580 3 whether whether IN cord-010119-t1x9gknd 5580 4 an an DT cord-010119-t1x9gknd 5580 5 alert alert NN cord-010119-t1x9gknd 5580 6 targeted target VBN cord-010119-t1x9gknd 5580 7 to to IN cord-010119-t1x9gknd 5580 8 a a DT cord-010119-t1x9gknd 5580 9 patient patient NN cord-010119-t1x9gknd 5580 10 's 's POS cord-010119-t1x9gknd 5580 11 transfusion transfusion NN cord-010119-t1x9gknd 5580 12 indication indication NN cord-010119-t1x9gknd 5580 13 could could MD cord-010119-t1x9gknd 5580 14 alter alter VB cord-010119-t1x9gknd 5580 15 provider provider NN cord-010119-t1x9gknd 5580 16 ordering order VBG cord-010119-t1x9gknd 5580 17 behavior behavior NN cord-010119-t1x9gknd 5580 18 . . . cord-010119-t1x9gknd 5581 1 Study Study NNP cord-010119-t1x9gknd 5581 2 Design Design NNP cord-010119-t1x9gknd 5581 3 / / SYM cord-010119-t1x9gknd 5581 4 Method method NN cord-010119-t1x9gknd 5581 5 : : : cord-010119-t1x9gknd 5582 1 This this DT cord-010119-t1x9gknd 5582 2 retrospective retrospective JJ cord-010119-t1x9gknd 5582 3 , , , cord-010119-t1x9gknd 5582 4 observational observational JJ cord-010119-t1x9gknd 5582 5 study study NN cord-010119-t1x9gknd 5582 6 over over IN cord-010119-t1x9gknd 5582 7 the the DT cord-010119-t1x9gknd 5582 8 course course NN cord-010119-t1x9gknd 5582 9 of of IN cord-010119-t1x9gknd 5582 10 seven seven CD cord-010119-t1x9gknd 5582 11 months month NNS cord-010119-t1x9gknd 5582 12 included include VBD cord-010119-t1x9gknd 5582 13 the the DT cord-010119-t1x9gknd 5582 14 inpatient inpatient JJ cord-010119-t1x9gknd 5582 15 adult adult NN cord-010119-t1x9gknd 5582 16 medicine medicine NN cord-010119-t1x9gknd 5582 17 floors floor NNS cord-010119-t1x9gknd 5582 18 and and CC cord-010119-t1x9gknd 5582 19 intensive intensive JJ cord-010119-t1x9gknd 5582 20 care care NN cord-010119-t1x9gknd 5582 21 units unit NNS cord-010119-t1x9gknd 5582 22 at at IN cord-010119-t1x9gknd 5582 23 a a DT cord-010119-t1x9gknd 5582 24 large large JJ cord-010119-t1x9gknd 5582 25 academic academic JJ cord-010119-t1x9gknd 5582 26 hospital hospital NN cord-010119-t1x9gknd 5582 27 . . . cord-010119-t1x9gknd 5583 1 Each each DT cord-010119-t1x9gknd 5583 2 time time NN cord-010119-t1x9gknd 5583 3 a a DT cord-010119-t1x9gknd 5583 4 crossmatch crossmatch NN cord-010119-t1x9gknd 5583 5 for for IN cord-010119-t1x9gknd 5583 6 packed pack VBN cord-010119-t1x9gknd 5583 7 red red JJ cord-010119-t1x9gknd 5583 8 blood blood NN cord-010119-t1x9gknd 5583 9 cells cell NNS cord-010119-t1x9gknd 5583 10 ( ( -LRB- cord-010119-t1x9gknd 5583 11 pRBCs prbcs RB cord-010119-t1x9gknd 5583 12 ) ) -RRB- cord-010119-t1x9gknd 5583 13 was be VBD cord-010119-t1x9gknd 5583 14 ordered order VBN cord-010119-t1x9gknd 5583 15 via via IN cord-010119-t1x9gknd 5583 16 the the DT cord-010119-t1x9gknd 5583 17 hospital hospital NN cord-010119-t1x9gknd 5583 18 's 's POS cord-010119-t1x9gknd 5583 19 electronic electronic JJ cord-010119-t1x9gknd 5583 20 ordering ordering NN cord-010119-t1x9gknd 5583 21 system system NN cord-010119-t1x9gknd 5583 22 , , , cord-010119-t1x9gknd 5583 23 an an DT cord-010119-t1x9gknd 5583 24 indication indication NN cord-010119-t1x9gknd 5583 25 ( ( -LRB- cord-010119-t1x9gknd 5583 26 e.g. e.g. RB cord-010119-t1x9gknd 5583 27 " " `` cord-010119-t1x9gknd 5583 28 hemodynamically hemodynamically RB cord-010119-t1x9gknd 5583 29 stable stable JJ cord-010119-t1x9gknd 5583 30 with with IN cord-010119-t1x9gknd 5583 31 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5583 32 < < XX cord-010119-t1x9gknd 5583 33 7.0 7.0 CD cord-010119-t1x9gknd 5583 34 g g NN cord-010119-t1x9gknd 5583 35 / / SYM cord-010119-t1x9gknd 5583 36 dL dl NN cord-010119-t1x9gknd 5583 37 " " '' cord-010119-t1x9gknd 5583 38 ) ) -RRB- cord-010119-t1x9gknd 5583 39 must must MD cord-010119-t1x9gknd 5583 40 be be VB cord-010119-t1x9gknd 5583 41 selected select VBN cord-010119-t1x9gknd 5583 42 . . . cord-010119-t1x9gknd 5584 1 If if IN cord-010119-t1x9gknd 5584 2 the the DT cord-010119-t1x9gknd 5584 3 indication indication NN cord-010119-t1x9gknd 5584 4 selected select VBN cord-010119-t1x9gknd 5584 5 contains contain VBZ cord-010119-t1x9gknd 5584 6 a a DT cord-010119-t1x9gknd 5584 7 threshold threshold NN cord-010119-t1x9gknd 5584 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5584 9 concentration concentration NN cord-010119-t1x9gknd 5584 10 , , , cord-010119-t1x9gknd 5584 11 and and CC cord-010119-t1x9gknd 5584 12 the the DT cord-010119-t1x9gknd 5584 13 patient patient NN cord-010119-t1x9gknd 5584 14 's 's POS cord-010119-t1x9gknd 5584 15 most most RBS cord-010119-t1x9gknd 5584 16 recent recent JJ cord-010119-t1x9gknd 5584 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5584 18 on on IN cord-010119-t1x9gknd 5584 19 record record NN cord-010119-t1x9gknd 5584 20 was be VBD cord-010119-t1x9gknd 5584 21 greater great JJR cord-010119-t1x9gknd 5584 22 than than IN cord-010119-t1x9gknd 5584 23 this this DT cord-010119-t1x9gknd 5584 24 threshold threshold NN cord-010119-t1x9gknd 5584 25 , , , cord-010119-t1x9gknd 5584 26 an an DT cord-010119-t1x9gknd 5584 27 interruptive interruptive JJ cord-010119-t1x9gknd 5584 28 alert alert NN cord-010119-t1x9gknd 5584 29 displaying display VBG cord-010119-t1x9gknd 5584 30 the the DT cord-010119-t1x9gknd 5584 31 patient patient NN cord-010119-t1x9gknd 5584 32 's 's POS cord-010119-t1x9gknd 5584 33 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5584 34 was be VBD cord-010119-t1x9gknd 5584 35 activated activate VBN cord-010119-t1x9gknd 5584 36 . . . cord-010119-t1x9gknd 5585 1 Ordering ordering NN cord-010119-t1x9gknd 5585 2 providers provider NNS cord-010119-t1x9gknd 5585 3 were be VBD cord-010119-t1x9gknd 5585 4 then then RB cord-010119-t1x9gknd 5585 5 given give VBN cord-010119-t1x9gknd 5585 6 three three CD cord-010119-t1x9gknd 5585 7 options option NNS cord-010119-t1x9gknd 5585 8 : : : cord-010119-t1x9gknd 5585 9 cancel cancel VB cord-010119-t1x9gknd 5585 10 the the DT cord-010119-t1x9gknd 5585 11 order order NN cord-010119-t1x9gknd 5585 12 , , , cord-010119-t1x9gknd 5585 13 select select VB cord-010119-t1x9gknd 5585 14 a a DT cord-010119-t1x9gknd 5585 15 more more RBR cord-010119-t1x9gknd 5585 16 appropriate appropriate JJ cord-010119-t1x9gknd 5585 17 indication indication NN cord-010119-t1x9gknd 5585 18 from from IN cord-010119-t1x9gknd 5585 19 a a DT cord-010119-t1x9gknd 5585 20 list list NN cord-010119-t1x9gknd 5585 21 , , , cord-010119-t1x9gknd 5585 22 or or CC cord-010119-t1x9gknd 5585 23 provide provide VB cord-010119-t1x9gknd 5585 24 an an DT cord-010119-t1x9gknd 5585 25 explanation explanation NN cord-010119-t1x9gknd 5585 26 via via IN cord-010119-t1x9gknd 5585 27 free free JJ cord-010119-t1x9gknd 5585 28 text text NN cord-010119-t1x9gknd 5585 29 as as IN cord-010119-t1x9gknd 5585 30 to to IN cord-010119-t1x9gknd 5585 31 why why WRB cord-010119-t1x9gknd 5585 32 transfusion transfusion NN cord-010119-t1x9gknd 5585 33 was be VBD cord-010119-t1x9gknd 5585 34 being be VBG cord-010119-t1x9gknd 5585 35 requested request VBN cord-010119-t1x9gknd 5585 36 outside outside RB cord-010119-t1x9gknd 5585 37 of of IN cord-010119-t1x9gknd 5585 38 approved approve VBN cord-010119-t1x9gknd 5585 39 indications indication NNS cord-010119-t1x9gknd 5585 40 . . . cord-010119-t1x9gknd 5586 1 An an DT cord-010119-t1x9gknd 5586 2 alert alert JJ cord-010119-t1x9gknd 5586 3 encounter encounter NN cord-010119-t1x9gknd 5586 4 was be VBD cord-010119-t1x9gknd 5586 5 defined define VBN cord-010119-t1x9gknd 5586 6 as as IN cord-010119-t1x9gknd 5586 7 all all DT cord-010119-t1x9gknd 5586 8 activations activation NNS cord-010119-t1x9gknd 5586 9 on on IN cord-010119-t1x9gknd 5586 10 a a DT cord-010119-t1x9gknd 5586 11 patient patient NN cord-010119-t1x9gknd 5586 12 within within IN cord-010119-t1x9gknd 5586 13 a a DT cord-010119-t1x9gknd 5586 14 six six CD cord-010119-t1x9gknd 5586 15 hour hour NN cord-010119-t1x9gknd 5586 16 period period NN cord-010119-t1x9gknd 5586 17 without without IN cord-010119-t1x9gknd 5586 18 an an DT cord-010119-t1x9gknd 5586 19 intervening intervene VBG cord-010119-t1x9gknd 5586 20 transfusion transfusion NN cord-010119-t1x9gknd 5586 21 Results result NNS cord-010119-t1x9gknd 5586 22 / / SYM cord-010119-t1x9gknd 5586 23 Finding finding NN cord-010119-t1x9gknd 5586 24 : : : cord-010119-t1x9gknd 5586 25 Over over IN cord-010119-t1x9gknd 5586 26 seven seven CD cord-010119-t1x9gknd 5586 27 months month NNS cord-010119-t1x9gknd 5586 28 , , , cord-010119-t1x9gknd 5586 29 there there EX cord-010119-t1x9gknd 5586 30 were be VBD cord-010119-t1x9gknd 5586 31 1732 1732 CD cord-010119-t1x9gknd 5586 32 unique unique JJ cord-010119-t1x9gknd 5586 33 alert alert NN cord-010119-t1x9gknd 5586 34 encounters encounter NNS cord-010119-t1x9gknd 5586 35 . . . cord-010119-t1x9gknd 5587 1 Of of IN cord-010119-t1x9gknd 5587 2 these these DT cord-010119-t1x9gknd 5587 3 , , , cord-010119-t1x9gknd 5587 4 1531 1531 CD cord-010119-t1x9gknd 5587 5 ( ( -LRB- cord-010119-t1x9gknd 5587 6 88.4 88.4 CD cord-010119-t1x9gknd 5587 7 % % NN cord-010119-t1x9gknd 5587 8 ) ) -RRB- cord-010119-t1x9gknd 5587 9 led lead VBD cord-010119-t1x9gknd 5587 10 to to IN cord-010119-t1x9gknd 5587 11 a a DT cord-010119-t1x9gknd 5587 12 crossmatch crossmatch NN cord-010119-t1x9gknd 5587 13 being be VBG cord-010119-t1x9gknd 5587 14 ordered order VBN cord-010119-t1x9gknd 5587 15 while while IN cord-010119-t1x9gknd 5587 16 201 201 CD cord-010119-t1x9gknd 5587 17 ( ( -LRB- cord-010119-t1x9gknd 5587 18 11.6 11.6 CD cord-010119-t1x9gknd 5587 19 % % NN cord-010119-t1x9gknd 5587 20 ) ) -RRB- cord-010119-t1x9gknd 5587 21 led lead VBD cord-010119-t1x9gknd 5587 22 to to IN cord-010119-t1x9gknd 5587 23 the the DT cord-010119-t1x9gknd 5587 24 order order NN cord-010119-t1x9gknd 5587 25 being be VBG cord-010119-t1x9gknd 5587 26 canceled cancel VBN cord-010119-t1x9gknd 5587 27 . . . cord-010119-t1x9gknd 5588 1 Providers provider NNS cord-010119-t1x9gknd 5588 2 were be VBD cord-010119-t1x9gknd 5588 3 more more RBR cord-010119-t1x9gknd 5588 4 likely likely JJ cord-010119-t1x9gknd 5588 5 to to TO cord-010119-t1x9gknd 5588 6 cancel cancel VB cord-010119-t1x9gknd 5588 7 transfusions transfusion NNS cord-010119-t1x9gknd 5588 8 in in IN cord-010119-t1x9gknd 5588 9 response response NN cord-010119-t1x9gknd 5588 10 to to IN cord-010119-t1x9gknd 5588 11 alerts alert NNS cord-010119-t1x9gknd 5588 12 for for IN cord-010119-t1x9gknd 5588 13 hemodynamically hemodynamically RB cord-010119-t1x9gknd 5588 14 stable stable JJ cord-010119-t1x9gknd 5588 15 patients patient NNS cord-010119-t1x9gknd 5588 16 with with IN cord-010119-t1x9gknd 5588 17 lower low JJR cord-010119-t1x9gknd 5588 18 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5588 19 thresholds threshold NNS cord-010119-t1x9gknd 5588 20 ( ( -LRB- cord-010119-t1x9gknd 5588 21 7.0 7.0 CD cord-010119-t1x9gknd 5588 22 g g NN cord-010119-t1x9gknd 5588 23 / / SYM cord-010119-t1x9gknd 5588 24 dL dl NN cord-010119-t1x9gknd 5588 25 ) ) -RRB- cord-010119-t1x9gknd 5588 26 than than IN cord-010119-t1x9gknd 5588 27 for for IN cord-010119-t1x9gknd 5588 28 more more RBR cord-010119-t1x9gknd 5588 29 complicated complicated JJ cord-010119-t1x9gknd 5588 30 patients patient NNS cord-010119-t1x9gknd 5588 31 ( ( -LRB- cord-010119-t1x9gknd 5588 32 bleeding bleed VBG cord-010119-t1x9gknd 5588 33 , , , cord-010119-t1x9gknd 5588 34 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 5588 35 disease disease NN cord-010119-t1x9gknd 5588 36 , , , cord-010119-t1x9gknd 5588 37 or or CC cord-010119-t1x9gknd 5588 38 preoperative preoperative JJ cord-010119-t1x9gknd 5588 39 ) ) -RRB- cord-010119-t1x9gknd 5588 40 with with IN cord-010119-t1x9gknd 5588 41 higher high JJR cord-010119-t1x9gknd 5588 42 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5588 43 thresholds threshold NNS cord-010119-t1x9gknd 5588 44 ( ( -LRB- cord-010119-t1x9gknd 5588 45 8.0 8.0 CD cord-010119-t1x9gknd 5588 46 or or CC cord-010119-t1x9gknd 5588 47 9.0 9.0 CD cord-010119-t1x9gknd 5588 48 g g NN cord-010119-t1x9gknd 5588 49 / / SYM cord-010119-t1x9gknd 5588 50 dL dL NNP cord-010119-t1x9gknd 5588 51 Background Background NNP cord-010119-t1x9gknd 5588 52 / / SYM cord-010119-t1x9gknd 5588 53 Case Case NNP cord-010119-t1x9gknd 5588 54 Studies Studies NNPS cord-010119-t1x9gknd 5588 55 : : : cord-010119-t1x9gknd 5588 56 The the DT cord-010119-t1x9gknd 5588 57 maximum maximum JJ cord-010119-t1x9gknd 5588 58 surgical surgical JJ cord-010119-t1x9gknd 5588 59 blood blood NN cord-010119-t1x9gknd 5588 60 ordering ordering NN cord-010119-t1x9gknd 5588 61 schedule schedule NN cord-010119-t1x9gknd 5588 62 ( ( -LRB- cord-010119-t1x9gknd 5588 63 MSBOS MSBOS NNP cord-010119-t1x9gknd 5588 64 ) ) -RRB- cord-010119-t1x9gknd 5588 65 is be VBZ cord-010119-t1x9gknd 5588 66 a a DT cord-010119-t1x9gknd 5588 67 list list NN cord-010119-t1x9gknd 5588 68 of of IN cord-010119-t1x9gknd 5588 69 surgical surgical JJ cord-010119-t1x9gknd 5588 70 procedures procedure NNS cord-010119-t1x9gknd 5588 71 performed perform VBN cord-010119-t1x9gknd 5588 72 along along IN cord-010119-t1x9gknd 5588 73 with with IN cord-010119-t1x9gknd 5588 74 a a DT cord-010119-t1x9gknd 5588 75 recommendation recommendation NN cord-010119-t1x9gknd 5588 76 for for IN cord-010119-t1x9gknd 5588 77 the the DT cord-010119-t1x9gknd 5588 78 extent extent NN cord-010119-t1x9gknd 5588 79 of of IN cord-010119-t1x9gknd 5588 80 pre pre JJ cord-010119-t1x9gknd 5588 81 - - JJ cord-010119-t1x9gknd 5588 82 transfusion transfusion JJ cord-010119-t1x9gknd 5588 83 testing testing NN cord-010119-t1x9gknd 5588 84 to to TO cord-010119-t1x9gknd 5588 85 be be VB cord-010119-t1x9gknd 5588 86 completed complete VBN cord-010119-t1x9gknd 5588 87 before before IN cord-010119-t1x9gknd 5588 88 the the DT cord-010119-t1x9gknd 5588 89 surgery surgery NN cord-010119-t1x9gknd 5588 90 begins begin VBZ cord-010119-t1x9gknd 5588 91 . . . cord-010119-t1x9gknd 5589 1 With with IN cord-010119-t1x9gknd 5589 2 improved improved JJ cord-010119-t1x9gknd 5589 3 patient patient JJ cord-010119-t1x9gknd 5589 4 data data NN cord-010119-t1x9gknd 5589 5 management management NN cord-010119-t1x9gknd 5589 6 systems system NNS cord-010119-t1x9gknd 5589 7 it -PRON- PRP cord-010119-t1x9gknd 5589 8 is be VBZ cord-010119-t1x9gknd 5589 9 now now RB cord-010119-t1x9gknd 5589 10 possible possible JJ cord-010119-t1x9gknd 5589 11 to to TO cord-010119-t1x9gknd 5589 12 create create VB cord-010119-t1x9gknd 5589 13 an an DT cord-010119-t1x9gknd 5589 14 MSBOS MSBOS NNP cord-010119-t1x9gknd 5589 15 based base VBN cord-010119-t1x9gknd 5589 16 on on IN cord-010119-t1x9gknd 5589 17 actual actual JJ cord-010119-t1x9gknd 5589 18 red red JJ cord-010119-t1x9gknd 5589 19 blood blood NN cord-010119-t1x9gknd 5589 20 cell cell NN cord-010119-t1x9gknd 5589 21 ( ( -LRB- cord-010119-t1x9gknd 5589 22 RBC RBC NNP cord-010119-t1x9gknd 5589 23 ) ) -RRB- cord-010119-t1x9gknd 5589 24 utilization utilization NN cord-010119-t1x9gknd 5589 25 data datum NNS cord-010119-t1x9gknd 5589 26 on on IN cord-010119-t1x9gknd 5589 27 a a DT cord-010119-t1x9gknd 5589 28 per per IN cord-010119-t1x9gknd 5589 29 - - HYPH cord-010119-t1x9gknd 5589 30 patient patient JJ cord-010119-t1x9gknd 5589 31 basis basis NN cord-010119-t1x9gknd 5589 32 . . . cord-010119-t1x9gknd 5590 1 This this DT cord-010119-t1x9gknd 5590 2 study study NN cord-010119-t1x9gknd 5590 3 investigated investigate VBD cord-010119-t1x9gknd 5590 4 the the DT cord-010119-t1x9gknd 5590 5 transfusion transfusion NN cord-010119-t1x9gknd 5590 6 patterns pattern NNS cord-010119-t1x9gknd 5590 7 at at IN cord-010119-t1x9gknd 5590 8 4 4 CD cord-010119-t1x9gknd 5590 9 academic academic JJ cord-010119-t1x9gknd 5590 10 hospitals hospital NNS cord-010119-t1x9gknd 5590 11 with with IN cord-010119-t1x9gknd 5590 12 data data NN cord-010119-t1x9gknd 5590 13 - - HYPH cord-010119-t1x9gknd 5590 14 derived derive VBN cord-010119-t1x9gknd 5590 15 MSBOS msbo NNS cord-010119-t1x9gknd 5590 16 . . . cord-010119-t1x9gknd 5591 1 Study Study NNP cord-010119-t1x9gknd 5591 2 Design Design NNP cord-010119-t1x9gknd 5591 3 / / SYM cord-010119-t1x9gknd 5591 4 Method method NN cord-010119-t1x9gknd 5591 5 : : : cord-010119-t1x9gknd 5592 1 The the DT cord-010119-t1x9gknd 5592 2 4 4 CD cord-010119-t1x9gknd 5592 3 hospitals hospital NNS cord-010119-t1x9gknd 5592 4 were be VBD cord-010119-t1x9gknd 5592 5 in in IN cord-010119-t1x9gknd 5592 6 2 2 CD cord-010119-t1x9gknd 5592 7 groups group NNS cord-010119-t1x9gknd 5592 8 , , , cord-010119-t1x9gknd 5592 9 with with IN cord-010119-t1x9gknd 5592 10 one one CD cord-010119-t1x9gknd 5592 11 shared share VBN cord-010119-t1x9gknd 5592 12 MSBOS msbo NNS cord-010119-t1x9gknd 5592 13 for for IN cord-010119-t1x9gknd 5592 14 each each DT cord-010119-t1x9gknd 5592 15 group group NN cord-010119-t1x9gknd 5592 16 . . . cord-010119-t1x9gknd 5593 1 Three three CD cord-010119-t1x9gknd 5593 2 of of IN cord-010119-t1x9gknd 5593 3 these these DT cord-010119-t1x9gknd 5593 4 hospitals hospital NNS cord-010119-t1x9gknd 5593 5 were be VBD cord-010119-t1x9gknd 5593 6 large large JJ cord-010119-t1x9gknd 5593 7 academic academic JJ cord-010119-t1x9gknd 5593 8 centers center NNS cord-010119-t1x9gknd 5593 9 while while IN cord-010119-t1x9gknd 5593 10 one one CD cord-010119-t1x9gknd 5593 11 was be VBD cord-010119-t1x9gknd 5593 12 a a DT cord-010119-t1x9gknd 5593 13 children child NNS cord-010119-t1x9gknd 5593 14 's 's POS cord-010119-t1x9gknd 5593 15 hospital hospital NN cord-010119-t1x9gknd 5593 16 . . . cord-010119-t1x9gknd 5594 1 At at IN cord-010119-t1x9gknd 5594 2 each each DT cord-010119-t1x9gknd 5594 3 center center NN cord-010119-t1x9gknd 5594 4 the the DT cord-010119-t1x9gknd 5594 5 MSBOS MSBOS NNPS cord-010119-t1x9gknd 5594 6 recommended recommend VBD cord-010119-t1x9gknd 5594 7 no no DT cord-010119-t1x9gknd 5594 8 pre pre JJ cord-010119-t1x9gknd 5594 9 - - JJ cord-010119-t1x9gknd 5594 10 transfusion transfusion JJ cord-010119-t1x9gknd 5594 11 testing testing NN cord-010119-t1x9gknd 5594 12 if if IN cord-010119-t1x9gknd 5594 13 5 5 CD cord-010119-t1x9gknd 5594 14 % % NN cord-010119-t1x9gknd 5594 15 of of IN cord-010119-t1x9gknd 5594 16 patients patient NNS cord-010119-t1x9gknd 5594 17 had have VBD cord-010119-t1x9gknd 5594 18 been be VBN cord-010119-t1x9gknd 5594 19 transfused transfuse VBN cord-010119-t1x9gknd 5594 20 for for IN cord-010119-t1x9gknd 5594 21 a a DT cord-010119-t1x9gknd 5594 22 specific specific JJ cord-010119-t1x9gknd 5594 23 procedure procedure NN cord-010119-t1x9gknd 5594 24 in in IN cord-010119-t1x9gknd 5594 25 the the DT cord-010119-t1x9gknd 5594 26 previous previous JJ cord-010119-t1x9gknd 5594 27 year year NN cord-010119-t1x9gknd 5594 28 , , , cord-010119-t1x9gknd 5595 1 a a DT cord-010119-t1x9gknd 5595 2 pre pre JJ cord-010119-t1x9gknd 5595 3 - - JJ cord-010119-t1x9gknd 5595 4 operative operative JJ cord-010119-t1x9gknd 5595 5 type type NN cord-010119-t1x9gknd 5595 6 and and CC cord-010119-t1x9gknd 5595 7 screen screen NN cord-010119-t1x9gknd 5595 8 ( ( -LRB- cord-010119-t1x9gknd 5595 9 T&S T&S NNP cord-010119-t1x9gknd 5595 10 ) ) -RRB- cord-010119-t1x9gknd 5595 11 if if IN cord-010119-t1x9gknd 5595 12 5 5 CD cord-010119-t1x9gknd 5595 13 - - SYM cord-010119-t1x9gknd 5595 14 24 24 CD cord-010119-t1x9gknd 5595 15 % % NN cord-010119-t1x9gknd 5595 16 of of IN cord-010119-t1x9gknd 5595 17 the the DT cord-010119-t1x9gknd 5595 18 patients patient NNS cord-010119-t1x9gknd 5595 19 had have VBD cord-010119-t1x9gknd 5595 20 been be VBN cord-010119-t1x9gknd 5595 21 transfused transfuse VBN cord-010119-t1x9gknd 5595 22 , , , cord-010119-t1x9gknd 5595 23 and and CC cord-010119-t1x9gknd 5595 24 a a DT cord-010119-t1x9gknd 5595 25 crossmatch crossmatch NN cord-010119-t1x9gknd 5595 26 of of IN cord-010119-t1x9gknd 5595 27 the the DT cord-010119-t1x9gknd 5595 28 median median JJ cord-010119-t1x9gknd 5595 29 number number NN cord-010119-t1x9gknd 5595 30 of of IN cord-010119-t1x9gknd 5595 31 RBCs rbc NNS cord-010119-t1x9gknd 5595 32 transfused transfuse VBN cord-010119-t1x9gknd 5595 33 if if IN cord-010119-t1x9gknd 5595 34 ! ! . cord-010119-t1x9gknd 5596 1 25 25 CD cord-010119-t1x9gknd 5596 2 % % NN cord-010119-t1x9gknd 5596 3 of of IN cord-010119-t1x9gknd 5596 4 the the DT cord-010119-t1x9gknd 5596 5 patients patient NNS cord-010119-t1x9gknd 5596 6 had have VBD cord-010119-t1x9gknd 5596 7 been be VBN cord-010119-t1x9gknd 5596 8 transfused transfuse VBN cord-010119-t1x9gknd 5596 9 . . . cord-010119-t1x9gknd 5597 1 Data datum NNS cord-010119-t1x9gknd 5597 2 were be VBD cord-010119-t1x9gknd 5597 3 collected collect VBN cord-010119-t1x9gknd 5597 4 at at IN cord-010119-t1x9gknd 5597 5 each each DT cord-010119-t1x9gknd 5597 6 center center NN cord-010119-t1x9gknd 5597 7 over over IN cord-010119-t1x9gknd 5597 8 a a DT cord-010119-t1x9gknd 5597 9 1 1 CD cord-010119-t1x9gknd 5597 10 month month NN cord-010119-t1x9gknd 5597 11 period period NN cord-010119-t1x9gknd 5597 12 between between IN cord-010119-t1x9gknd 5597 13 January January NNP cord-010119-t1x9gknd 5597 14 to to IN cord-010119-t1x9gknd 5597 15 March March NNP cord-010119-t1x9gknd 5597 16 2017 2017 CD cord-010119-t1x9gknd 5597 17 and and CC cord-010119-t1x9gknd 5597 18 included include VBD cord-010119-t1x9gknd 5597 19 a a DT cord-010119-t1x9gknd 5597 20 maximum maximum NN cord-010119-t1x9gknd 5597 21 of of IN cord-010119-t1x9gknd 5597 22 400 400 CD cord-010119-t1x9gknd 5597 23 cases case NNS cord-010119-t1x9gknd 5597 24 per per IN cord-010119-t1x9gknd 5597 25 hospital hospital NN cord-010119-t1x9gknd 5597 26 during during IN cord-010119-t1x9gknd 5597 27 that that DT cord-010119-t1x9gknd 5597 28 one one CD cord-010119-t1x9gknd 5597 29 month month NN cord-010119-t1x9gknd 5597 30 to to TO cord-010119-t1x9gknd 5597 31 ensure ensure VB cord-010119-t1x9gknd 5597 32 equal equal JJ cord-010119-t1x9gknd 5597 33 representation representation NN cord-010119-t1x9gknd 5597 34 between between IN cord-010119-t1x9gknd 5597 35 centers center NNS cord-010119-t1x9gknd 5597 36 Results/ Results/ . cord-010119-t1x9gknd 5598 1 Finding finding NN cord-010119-t1x9gknd 5598 2 : : : cord-010119-t1x9gknd 5598 3 Between between IN cord-010119-t1x9gknd 5598 4 these these DT cord-010119-t1x9gknd 5598 5 4 4 CD cord-010119-t1x9gknd 5598 6 centers center NNS cord-010119-t1x9gknd 5598 7 there there EX cord-010119-t1x9gknd 5598 8 were be VBD cord-010119-t1x9gknd 5598 9 a a DT cord-010119-t1x9gknd 5598 10 total total NN cord-010119-t1x9gknd 5598 11 of of IN cord-010119-t1x9gknd 5598 12 1599 1599 CD cord-010119-t1x9gknd 5598 13 cases case NNS cord-010119-t1x9gknd 5598 14 analyzed analyze VBN cord-010119-t1x9gknd 5598 15 . . . cord-010119-t1x9gknd 5599 1 Some some DT cord-010119-t1x9gknd 5599 2 of of IN cord-010119-t1x9gknd 5599 3 the the DT cord-010119-t1x9gknd 5599 4 more more RBR cord-010119-t1x9gknd 5599 5 frequently frequently RB cord-010119-t1x9gknd 5599 6 performed perform VBN cord-010119-t1x9gknd 5599 7 surgeries surgery NNS cord-010119-t1x9gknd 5599 8 included include VBD cord-010119-t1x9gknd 5599 9 orthopedics orthopedic NNS cord-010119-t1x9gknd 5599 10 ( ( -LRB- cord-010119-t1x9gknd 5599 11 23 23 CD cord-010119-t1x9gknd 5599 12 % % NN cord-010119-t1x9gknd 5599 13 of of IN cord-010119-t1x9gknd 5599 14 cases case NNS cord-010119-t1x9gknd 5599 15 ) ) -RRB- cord-010119-t1x9gknd 5599 16 , , , cord-010119-t1x9gknd 5599 17 general general JJ cord-010119-t1x9gknd 5599 18 surgery surgery NN cord-010119-t1x9gknd 5599 19 ( ( -LRB- cord-010119-t1x9gknd 5599 20 16 16 CD cord-010119-t1x9gknd 5599 21 % % NN cord-010119-t1x9gknd 5599 22 ) ) -RRB- cord-010119-t1x9gknd 5599 23 and and CC cord-010119-t1x9gknd 5599 24 cardiac cardiac JJ cord-010119-t1x9gknd 5599 25 surgery surgery NN cord-010119-t1x9gknd 5599 26 ( ( -LRB- cord-010119-t1x9gknd 5599 27 11 11 CD cord-010119-t1x9gknd 5599 28 % % NN cord-010119-t1x9gknd 5599 29 ) ) -RRB- cord-010119-t1x9gknd 5599 30 . . . cord-010119-t1x9gknd 5600 1 There there EX cord-010119-t1x9gknd 5600 2 were be VBD cord-010119-t1x9gknd 5600 3 1362 1362 CD cord-010119-t1x9gknd 5600 4 T&S T&S NNP cord-010119-t1x9gknd 5600 5 ordered order VBN cord-010119-t1x9gknd 5600 6 for for IN cord-010119-t1x9gknd 5600 7 these these DT cord-010119-t1x9gknd 5600 8 cases case NNS cord-010119-t1x9gknd 5600 9 , , , cord-010119-t1x9gknd 5600 10 of of IN cord-010119-t1x9gknd 5600 11 which which WDT cord-010119-t1x9gknd 5600 12 5 5 CD cord-010119-t1x9gknd 5600 13 were be VBD cord-010119-t1x9gknd 5600 14 positive positive JJ cord-010119-t1x9gknd 5600 15 for for IN cord-010119-t1x9gknd 5600 16 antibodies antibody NNS cord-010119-t1x9gknd 5600 17 on on IN cord-010119-t1x9gknd 5600 18 the the DT cord-010119-t1x9gknd 5600 19 day day NN cord-010119-t1x9gknd 5600 20 of of IN cord-010119-t1x9gknd 5600 21 surgery surgery NN cord-010119-t1x9gknd 5600 22 . . . cord-010119-t1x9gknd 5601 1 Of of IN cord-010119-t1x9gknd 5601 2 all all PDT cord-010119-t1x9gknd 5601 3 the the DT cord-010119-t1x9gknd 5601 4 T&S T&S NNP cord-010119-t1x9gknd 5601 5 ordered order VBD cord-010119-t1x9gknd 5601 6 , , , cord-010119-t1x9gknd 5601 7 52 52 CD cord-010119-t1x9gknd 5601 8 % % NN cord-010119-t1x9gknd 5601 9 were be VBD cord-010119-t1x9gknd 5601 10 ordered order VBN cord-010119-t1x9gknd 5601 11 in in IN cord-010119-t1x9gknd 5601 12 accord accord NN cord-010119-t1x9gknd 5601 13 with with IN cord-010119-t1x9gknd 5601 14 the the DT cord-010119-t1x9gknd 5601 15 MSBOS MSBOS NNP cord-010119-t1x9gknd 5601 16 recommendation recommendation NN cord-010119-t1x9gknd 5601 17 , , , cord-010119-t1x9gknd 5601 18 26 26 CD cord-010119-t1x9gknd 5601 19 % % NN cord-010119-t1x9gknd 5601 20 were be VBD cord-010119-t1x9gknd 5601 21 ordered order VBN cord-010119-t1x9gknd 5601 22 when when WRB cord-010119-t1x9gknd 5601 23 the the DT cord-010119-t1x9gknd 5601 24 MSBOS MSBOS NNPS cord-010119-t1x9gknd 5601 25 did do VBD cord-010119-t1x9gknd 5601 26 not not RB cord-010119-t1x9gknd 5601 27 recommend recommend VB cord-010119-t1x9gknd 5601 28 one one CD cord-010119-t1x9gknd 5601 29 , , , cord-010119-t1x9gknd 5601 30 and and CC cord-010119-t1x9gknd 5601 31 in in IN cord-010119-t1x9gknd 5601 32 0.2 0.2 CD cord-010119-t1x9gknd 5601 33 % % NN cord-010119-t1x9gknd 5601 34 a a DT cord-010119-t1x9gknd 5601 35 T&S t&s NN cord-010119-t1x9gknd 5601 36 was be VBD cord-010119-t1x9gknd 5601 37 not not RB cord-010119-t1x9gknd 5601 38 ordered order VBN cord-010119-t1x9gknd 5601 39 when when WRB cord-010119-t1x9gknd 5601 40 the the DT cord-010119-t1x9gknd 5601 41 MSBOS MSBOS NNP cord-010119-t1x9gknd 5601 42 recommended recommend VBD cord-010119-t1x9gknd 5601 43 one one CD cord-010119-t1x9gknd 5601 44 . . . cord-010119-t1x9gknd 5601 45 _SP cord-010119-t1x9gknd 5602 1 Background Background NNP cord-010119-t1x9gknd 5602 2 / / SYM cord-010119-t1x9gknd 5602 3 Case Case NNP cord-010119-t1x9gknd 5602 4 Studies Studies NNPS cord-010119-t1x9gknd 5603 1 : : : cord-010119-t1x9gknd 5603 2 Peripartum Peripartum NNP cord-010119-t1x9gknd 5603 3 blood blood NN cord-010119-t1x9gknd 5603 4 transfusion transfusion NN cord-010119-t1x9gknd 5603 5 is be VBZ cord-010119-t1x9gknd 5603 6 more more RBR cord-010119-t1x9gknd 5603 7 common common JJ cord-010119-t1x9gknd 5603 8 in in IN cord-010119-t1x9gknd 5603 9 South South NNP cord-010119-t1x9gknd 5603 10 Africa Africa NNP cord-010119-t1x9gknd 5603 11 than than IN cord-010119-t1x9gknd 5603 12 in in IN cord-010119-t1x9gknd 5603 13 the the DT cord-010119-t1x9gknd 5603 14 USA USA NNP cord-010119-t1x9gknd 5603 15 and and CC cord-010119-t1x9gknd 5603 16 recent recent JJ cord-010119-t1x9gknd 5603 17 studies study NNS cord-010119-t1x9gknd 5603 18 have have VBP cord-010119-t1x9gknd 5603 19 demonstrated demonstrate VBN cord-010119-t1x9gknd 5603 20 that that IN cord-010119-t1x9gknd 5603 21 antenatal antenatal JJ cord-010119-t1x9gknd 5603 22 anemia anemia NN cord-010119-t1x9gknd 5603 23 is be VBZ cord-010119-t1x9gknd 5603 24 a a DT cord-010119-t1x9gknd 5603 25 strong strong JJ cord-010119-t1x9gknd 5603 26 risk risk NN cord-010119-t1x9gknd 5603 27 factor factor NN cord-010119-t1x9gknd 5603 28 for for IN cord-010119-t1x9gknd 5603 29 such such JJ cord-010119-t1x9gknd 5603 30 transfusion transfusion NN cord-010119-t1x9gknd 5603 31 ( ( -LRB- cord-010119-t1x9gknd 5603 32 odds odd NNS cord-010119-t1x9gknd 5603 33 ratio ratio NN cord-010119-t1x9gknd 5603 34 5 5 CD cord-010119-t1x9gknd 5603 35 6.12 6.12 CD cord-010119-t1x9gknd 5603 36 for for IN cord-010119-t1x9gknd 5603 37 prenatal prenatal JJ cord-010119-t1x9gknd 5603 38 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5603 39 ( ( -LRB- cord-010119-t1x9gknd 5603 40 Hgb Hgb NNP cord-010119-t1x9gknd 5603 41 ) ) -RRB- cord-010119-t1x9gknd 5604 1 8 8 CD cord-010119-t1x9gknd 5604 2 - - SYM cord-010119-t1x9gknd 5604 3 8.9 8.9 CD cord-010119-t1x9gknd 5604 4 ) ) -RRB- cord-010119-t1x9gknd 5604 5 . . . cord-010119-t1x9gknd 5605 1 We -PRON- PRP cord-010119-t1x9gknd 5605 2 therefore therefore RB cord-010119-t1x9gknd 5605 3 analyzed analyze VBD cord-010119-t1x9gknd 5605 4 the the DT cord-010119-t1x9gknd 5605 5 etiology etiology NN cord-010119-t1x9gknd 5605 6 and and CC cord-010119-t1x9gknd 5605 7 characteristics characteristic NNS cord-010119-t1x9gknd 5605 8 of of IN cord-010119-t1x9gknd 5605 9 antenatal antenatal JJ cord-010119-t1x9gknd 5605 10 anemia anemia NN cord-010119-t1x9gknd 5605 11 according accord VBG cord-010119-t1x9gknd 5605 12 to to IN cord-010119-t1x9gknd 5605 13 HIV HIV NNP cord-010119-t1x9gknd 5605 14 status status NN cord-010119-t1x9gknd 5605 15 at at IN cord-010119-t1x9gknd 5605 16 a a DT cord-010119-t1x9gknd 5605 17 large large JJ cord-010119-t1x9gknd 5605 18 hospital hospital NN cord-010119-t1x9gknd 5605 19 with with IN cord-010119-t1x9gknd 5605 20 a a DT cord-010119-t1x9gknd 5605 21 HIV HIV NNP cord-010119-t1x9gknd 5605 22 prevalence prevalence NN cord-010119-t1x9gknd 5605 23 of of IN cord-010119-t1x9gknd 5605 24 29 29 CD cord-010119-t1x9gknd 5605 25 % % NN cord-010119-t1x9gknd 5605 26 among among IN cord-010119-t1x9gknd 5605 27 obstetric obstetric JJ cord-010119-t1x9gknd 5605 28 patients patient NNS cord-010119-t1x9gknd 5605 29 . . . cord-010119-t1x9gknd 5606 1 Study Study NNP cord-010119-t1x9gknd 5606 2 Design Design NNP cord-010119-t1x9gknd 5606 3 / / SYM cord-010119-t1x9gknd 5606 4 Method method NN cord-010119-t1x9gknd 5606 5 : : : cord-010119-t1x9gknd 5606 6 We -PRON- PRP cord-010119-t1x9gknd 5606 7 studied study VBD cord-010119-t1x9gknd 5606 8 a a DT cord-010119-t1x9gknd 5606 9 sample sample NN cord-010119-t1x9gknd 5606 10 of of IN cord-010119-t1x9gknd 5606 11 anemic anemic JJ cord-010119-t1x9gknd 5606 12 ( ( -LRB- cord-010119-t1x9gknd 5606 13 Hgb<10.0 hgb<10.0 IN cord-010119-t1x9gknd 5606 14 g g NN cord-010119-t1x9gknd 5606 15 / / SYM cord-010119-t1x9gknd 5606 16 dL dl NN cord-010119-t1x9gknd 5606 17 ) ) -RRB- cord-010119-t1x9gknd 5606 18 pregnant pregnant JJ cord-010119-t1x9gknd 5606 19 women woman NNS cord-010119-t1x9gknd 5606 20 who who WP cord-010119-t1x9gknd 5606 21 were be VBD cord-010119-t1x9gknd 5606 22 referred refer VBN cord-010119-t1x9gknd 5606 23 to to IN cord-010119-t1x9gknd 5606 24 an an DT cord-010119-t1x9gknd 5606 25 antenatal antenatal JJ cord-010119-t1x9gknd 5606 26 anemia anemia NN cord-010119-t1x9gknd 5606 27 clinic clinic NN cord-010119-t1x9gknd 5606 28 at at IN cord-010119-t1x9gknd 5606 29 a a DT cord-010119-t1x9gknd 5606 30 large large JJ cord-010119-t1x9gknd 5606 31 hospital hospital NN cord-010119-t1x9gknd 5606 32 in in IN cord-010119-t1x9gknd 5606 33 South South NNP cord-010119-t1x9gknd 5606 34 Africa Africa NNP cord-010119-t1x9gknd 5606 35 . . . cord-010119-t1x9gknd 5607 1 Clinical clinical JJ cord-010119-t1x9gknd 5607 2 information information NN cord-010119-t1x9gknd 5607 3 was be VBD cord-010119-t1x9gknd 5607 4 abstracted abstract VBN cord-010119-t1x9gknd 5607 5 and and CC cord-010119-t1x9gknd 5607 6 blood blood NN cord-010119-t1x9gknd 5607 7 was be VBD cord-010119-t1x9gknd 5607 8 sent send VBN cord-010119-t1x9gknd 5607 9 for for IN cord-010119-t1x9gknd 5607 10 laboratory laboratory NN cord-010119-t1x9gknd 5607 11 studies study NNS cord-010119-t1x9gknd 5607 12 . . . cord-010119-t1x9gknd 5608 1 T t NN cord-010119-t1x9gknd 5608 2 - - HYPH cord-010119-t1x9gknd 5608 3 tests test NNS cord-010119-t1x9gknd 5608 4 were be VBD cord-010119-t1x9gknd 5608 5 used use VBN cord-010119-t1x9gknd 5608 6 to to TO cord-010119-t1x9gknd 5608 7 compare compare VB cord-010119-t1x9gknd 5608 8 continuous continuous JJ cord-010119-t1x9gknd 5608 9 variables variable NNS cord-010119-t1x9gknd 5608 10 between between IN cord-010119-t1x9gknd 5608 11 groups group NNS cord-010119-t1x9gknd 5608 12 . . . cord-010119-t1x9gknd 5609 1 Results result NNS cord-010119-t1x9gknd 5609 2 / / SYM cord-010119-t1x9gknd 5609 3 Findings finding NNS cord-010119-t1x9gknd 5609 4 : : : cord-010119-t1x9gknd 5610 1 A a DT cord-010119-t1x9gknd 5610 2 total total NN cord-010119-t1x9gknd 5610 3 of of IN cord-010119-t1x9gknd 5610 4 301 301 CD cord-010119-t1x9gknd 5610 5 women woman NNS cord-010119-t1x9gknd 5610 6 were be VBD cord-010119-t1x9gknd 5610 7 enrolled enrol VBN cord-010119-t1x9gknd 5610 8 , , , cord-010119-t1x9gknd 5610 9 with with IN cord-010119-t1x9gknd 5610 10 median median JJ cord-010119-t1x9gknd 5610 11 age age NN cord-010119-t1x9gknd 5610 12 27 27 CD cord-010119-t1x9gknd 5610 13 ( ( -LRB- cord-010119-t1x9gknd 5610 14 interquartile interquartile JJ cord-010119-t1x9gknd 5610 15 range range VBP cord-010119-t1x9gknd 5610 16 23 23 CD cord-010119-t1x9gknd 5610 17 - - SYM cord-010119-t1x9gknd 5610 18 32 32 CD cord-010119-t1x9gknd 5610 19 ) ) -RRB- cord-010119-t1x9gknd 5610 20 years year NNS cord-010119-t1x9gknd 5610 21 , , , cord-010119-t1x9gknd 5610 22 median median JJ cord-010119-t1x9gknd 5610 23 gravida gravida NN cord-010119-t1x9gknd 5611 1 2 2 LS cord-010119-t1x9gknd 5611 2 / / SYM cord-010119-t1x9gknd 5611 3 para para NNP cord-010119-t1x9gknd 5611 4 1 1 CD cord-010119-t1x9gknd 5611 5 and and CC cord-010119-t1x9gknd 5611 6 median median JJ cord-010119-t1x9gknd 5611 7 gestational gestational JJ cord-010119-t1x9gknd 5611 8 age age NN cord-010119-t1x9gknd 5611 9 28 28 CD cord-010119-t1x9gknd 5611 10 weeks week NNS cord-010119-t1x9gknd 5611 11 . . . cord-010119-t1x9gknd 5612 1 Mean mean JJ cord-010119-t1x9gknd 5612 2 Hgb Hgb NNP cord-010119-t1x9gknd 5612 3 before before IN cord-010119-t1x9gknd 5612 4 referral referral NN cord-010119-t1x9gknd 5612 5 was be VBD cord-010119-t1x9gknd 5612 6 7.5 7.5 CD cord-010119-t1x9gknd 5612 7 g g NN cord-010119-t1x9gknd 5612 8 / / SYM cord-010119-t1x9gknd 5612 9 dL dl NN cord-010119-t1x9gknd 5612 10 and and CC cord-010119-t1x9gknd 5612 11 most most JJS cord-010119-t1x9gknd 5612 12 were be VBD cord-010119-t1x9gknd 5612 13 already already RB cord-010119-t1x9gknd 5612 14 taking take VBG cord-010119-t1x9gknd 5612 15 oral oral JJ cord-010119-t1x9gknd 5612 16 iron iron NN cord-010119-t1x9gknd 5612 17 therapy therapy NN cord-010119-t1x9gknd 5612 18 . . . cord-010119-t1x9gknd 5613 1 A a DT cord-010119-t1x9gknd 5613 2 total total NN cord-010119-t1x9gknd 5613 3 of of IN cord-010119-t1x9gknd 5613 4 169 169 CD cord-010119-t1x9gknd 5613 5 women woman NNS cord-010119-t1x9gknd 5613 6 were be VBD cord-010119-t1x9gknd 5613 7 HIV HIV NNP cord-010119-t1x9gknd 5613 8 positive positive JJ cord-010119-t1x9gknd 5613 9 with with IN cord-010119-t1x9gknd 5613 10 mean mean NN cord-010119-t1x9gknd 5614 1 CD41 CD41 NNP cord-010119-t1x9gknd 5614 2 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 5614 3 counts count VBZ cord-010119-t1x9gknd 5614 4 of of IN cord-010119-t1x9gknd 5614 5 394 394 CD cord-010119-t1x9gknd 5614 6 cells cell NNS cord-010119-t1x9gknd 5614 7 / / SYM cord-010119-t1x9gknd 5614 8 uL ul NN cord-010119-t1x9gknd 5614 9 ; ; : cord-010119-t1x9gknd 5614 10 29 29 CD cord-010119-t1x9gknd 5614 11 ( ( -LRB- cord-010119-t1x9gknd 5614 12 12 12 CD cord-010119-t1x9gknd 5614 13 % % NN cord-010119-t1x9gknd 5614 14 ) ) -RRB- cord-010119-t1x9gknd 5614 15 of of IN cord-010119-t1x9gknd 5614 16 HIV HIV NNP cord-010119-t1x9gknd 5614 17 positive positive JJ cord-010119-t1x9gknd 5614 18 subjects subject NNS cord-010119-t1x9gknd 5614 19 were be VBD cord-010119-t1x9gknd 5614 20 on on IN cord-010119-t1x9gknd 5614 21 anti anti JJ cord-010119-t1x9gknd 5614 22 - - JJ cord-010119-t1x9gknd 5614 23 retroviral retroviral JJ cord-010119-t1x9gknd 5614 24 therapy therapy NN cord-010119-t1x9gknd 5614 25 ( ( -LRB- cord-010119-t1x9gknd 5614 26 ART art NN cord-010119-t1x9gknd 5614 27 ) ) -RRB- cord-010119-t1x9gknd 5614 28 prior prior RB cord-010119-t1x9gknd 5614 29 to to IN cord-010119-t1x9gknd 5614 30 the the DT cord-010119-t1x9gknd 5614 31 pregnancy pregnancy NN cord-010119-t1x9gknd 5614 32 and and CC cord-010119-t1x9gknd 5614 33 156 156 CD cord-010119-t1x9gknd 5614 34 ( ( -LRB- cord-010119-t1x9gknd 5614 35 92 92 CD cord-010119-t1x9gknd 5614 36 % % NN cord-010119-t1x9gknd 5614 37 ) ) -RRB- cord-010119-t1x9gknd 5614 38 were be VBD cord-010119-t1x9gknd 5614 39 on on IN cord-010119-t1x9gknd 5614 40 ART art NN cord-010119-t1x9gknd 5614 41 during during IN cord-010119-t1x9gknd 5614 42 the the DT cord-010119-t1x9gknd 5614 43 current current JJ cord-010119-t1x9gknd 5614 44 pregnancy pregnancy NN cord-010119-t1x9gknd 5614 45 . . . cord-010119-t1x9gknd 5615 1 Iron iron NN cord-010119-t1x9gknd 5615 2 deficiency deficiency NN cord-010119-t1x9gknd 5615 3 anemia anemia NN cord-010119-t1x9gknd 5615 4 was be VBD cord-010119-t1x9gknd 5615 5 the the DT cord-010119-t1x9gknd 5615 6 overwhelmingly overwhelmingly RB cord-010119-t1x9gknd 5615 7 prevalent prevalent JJ cord-010119-t1x9gknd 5615 8 diagnosis diagnosis NN cord-010119-t1x9gknd 5615 9 , , , cord-010119-t1x9gknd 5615 10 present present JJ cord-010119-t1x9gknd 5615 11 in in IN cord-010119-t1x9gknd 5615 12 292 292 CD cord-010119-t1x9gknd 5615 13 ( ( -LRB- cord-010119-t1x9gknd 5615 14 97 97 CD cord-010119-t1x9gknd 5615 15 % % NN cord-010119-t1x9gknd 5615 16 ) ) -RRB- cord-010119-t1x9gknd 5615 17 of of IN cord-010119-t1x9gknd 5615 18 women woman NNS cord-010119-t1x9gknd 5615 19 . . . cord-010119-t1x9gknd 5616 1 There there EX cord-010119-t1x9gknd 5616 2 was be VBD cord-010119-t1x9gknd 5616 3 concurrent concurrent JJ cord-010119-t1x9gknd 5616 4 chronic chronic JJ cord-010119-t1x9gknd 5616 5 disease disease NN cord-010119-t1x9gknd 5616 6 ( ( -LRB- cord-010119-t1x9gknd 5616 7 n52 n52 NNP cord-010119-t1x9gknd 5616 8 ) ) -RRB- cord-010119-t1x9gknd 5616 9 , , , cord-010119-t1x9gknd 5616 10 infection infection NN cord-010119-t1x9gknd 5616 11 ( ( -LRB- cord-010119-t1x9gknd 5616 12 n52 n52 NNP cord-010119-t1x9gknd 5616 13 ) ) -RRB- cord-010119-t1x9gknd 5616 14 , , , cord-010119-t1x9gknd 5616 15 vitamin vitamin NN cord-010119-t1x9gknd 5616 16 B12 B12 NNP cord-010119-t1x9gknd 5616 17 deficiency deficiency NN cord-010119-t1x9gknd 5616 18 ( ( -LRB- cord-010119-t1x9gknd 5616 19 n52 n52 NNP cord-010119-t1x9gknd 5616 20 ) ) -RRB- cord-010119-t1x9gknd 5616 21 and and CC cord-010119-t1x9gknd 5616 22 antenatal antenatal JJ cord-010119-t1x9gknd 5616 23 hemorrhage hemorrhage NN cord-010119-t1x9gknd 5616 24 ( ( -LRB- cord-010119-t1x9gknd 5616 25 n56 n56 NN cord-010119-t1x9gknd 5616 26 ) ) -RRB- cord-010119-t1x9gknd 5616 27 ; ; : cord-010119-t1x9gknd 5616 28 10 10 CD cord-010119-t1x9gknd 5616 29 had have VBD cord-010119-t1x9gknd 5616 30 other other JJ cord-010119-t1x9gknd 5616 31 / / SYM cord-010119-t1x9gknd 5616 32 unknown unknown JJ cord-010119-t1x9gknd 5616 33 / / SYM cord-010119-t1x9gknd 5616 34 missing missing JJ cord-010119-t1x9gknd 5616 35 causes cause NNS cord-010119-t1x9gknd 5616 36 of of IN cord-010119-t1x9gknd 5616 37 anemia anemia NN cord-010119-t1x9gknd 5616 38 . . . cord-010119-t1x9gknd 5617 1 There there EX cord-010119-t1x9gknd 5617 2 were be VBD cord-010119-t1x9gknd 5617 3 few few JJ cord-010119-t1x9gknd 5617 4 pregnancy pregnancy NN cord-010119-t1x9gknd 5617 5 related relate VBN cord-010119-t1x9gknd 5617 6 complications complication NNS cord-010119-t1x9gknd 5617 7 . . . cord-010119-t1x9gknd 5618 1 HIV HIV NNP cord-010119-t1x9gknd 5618 2 positive positive JJ cord-010119-t1x9gknd 5618 3 women woman NNS cord-010119-t1x9gknd 5618 4 had have VBD cord-010119-t1x9gknd 5618 5 higher high JJR cord-010119-t1x9gknd 5618 6 levels level NNS cord-010119-t1x9gknd 5618 7 of of IN cord-010119-t1x9gknd 5618 8 C c NN cord-010119-t1x9gknd 5618 9 - - HYPH cord-010119-t1x9gknd 5618 10 reactive reactive JJ cord-010119-t1x9gknd 5618 11 protein protein NN cord-010119-t1x9gknd 5618 12 but but CC cord-010119-t1x9gknd 5618 13 slightly slightly RB cord-010119-t1x9gknd 5618 14 lower low JJR cord-010119-t1x9gknd 5618 15 levels level NNS cord-010119-t1x9gknd 5618 16 of of IN cord-010119-t1x9gknd 5618 17 transferrin transferrin NN cord-010119-t1x9gknd 5618 18 , , , cord-010119-t1x9gknd 5618 19 soluble soluble JJ cord-010119-t1x9gknd 5618 20 transferrin transferrin NN cord-010119-t1x9gknd 5618 21 receptor receptor NN cord-010119-t1x9gknd 5618 22 and and CC cord-010119-t1x9gknd 5618 23 RBC RBC NNP cord-010119-t1x9gknd 5618 24 folate folate NN cord-010119-t1x9gknd 5618 25 than than IN cord-010119-t1x9gknd 5618 26 HIV HIV NNP cord-010119-t1x9gknd 5618 27 negative negative JJ cord-010119-t1x9gknd 5618 28 women woman NNS cord-010119-t1x9gknd 5618 29 ( ( -LRB- cord-010119-t1x9gknd 5618 30 Table table NN cord-010119-t1x9gknd 5618 31 ) ) -RRB- cord-010119-t1x9gknd 5618 32 . . . cord-010119-t1x9gknd 5619 1 Conclusion conclusion NN cord-010119-t1x9gknd 5619 2 : : : cord-010119-t1x9gknd 5620 1 Iron iron NN cord-010119-t1x9gknd 5620 2 deficiency deficiency NN cord-010119-t1x9gknd 5620 3 is be VBZ cord-010119-t1x9gknd 5620 4 the the DT cord-010119-t1x9gknd 5620 5 overwhelming overwhelming JJ cord-010119-t1x9gknd 5620 6 cause cause NN cord-010119-t1x9gknd 5620 7 of of IN cord-010119-t1x9gknd 5620 8 antenatal antenatal JJ cord-010119-t1x9gknd 5620 9 anemia anemia NN cord-010119-t1x9gknd 5620 10 among among IN cord-010119-t1x9gknd 5620 11 South south JJ cord-010119-t1x9gknd 5620 12 African african JJ cord-010119-t1x9gknd 5620 13 pregnant pregnant JJ cord-010119-t1x9gknd 5620 14 women woman NNS cord-010119-t1x9gknd 5620 15 . . . cord-010119-t1x9gknd 5621 1 Compared compare VBN cord-010119-t1x9gknd 5621 2 to to IN cord-010119-t1x9gknd 5621 3 HIV HIV NNP cord-010119-t1x9gknd 5621 4 - - HYPH cord-010119-t1x9gknd 5621 5 negative negative JJ cord-010119-t1x9gknd 5621 6 women woman NNS cord-010119-t1x9gknd 5621 7 , , , cord-010119-t1x9gknd 5621 8 HIV HIV NNP cord-010119-t1x9gknd 5621 9 - - HYPH cord-010119-t1x9gknd 5621 10 positive positive JJ cord-010119-t1x9gknd 5621 11 women woman NNS cord-010119-t1x9gknd 5621 12 had have VBD cord-010119-t1x9gknd 5621 13 evidence evidence NN cord-010119-t1x9gknd 5621 14 of of IN cord-010119-t1x9gknd 5621 15 increased increase VBN cord-010119-t1x9gknd 5621 16 inflammation inflammation NN cord-010119-t1x9gknd 5621 17 , , , cord-010119-t1x9gknd 5621 18 relatively relatively RB cord-010119-t1x9gknd 5621 19 little little JJ cord-010119-t1x9gknd 5621 20 differences difference NNS cord-010119-t1x9gknd 5621 21 in in IN cord-010119-t1x9gknd 5621 22 iron iron NN cord-010119-t1x9gknd 5621 23 studies study NNS cord-010119-t1x9gknd 5621 24 after after IN cord-010119-t1x9gknd 5621 25 early early JJ cord-010119-t1x9gknd 5621 26 treatment treatment NN cord-010119-t1x9gknd 5621 27 with with IN cord-010119-t1x9gknd 5621 28 iron iron NN cord-010119-t1x9gknd 5621 29 and and CC cord-010119-t1x9gknd 5621 30 lower low JJR cord-010119-t1x9gknd 5621 31 red red JJ cord-010119-t1x9gknd 5621 32 cell cell NN cord-010119-t1x9gknd 5621 33 folate folate NN cord-010119-t1x9gknd 5621 34 . . . cord-010119-t1x9gknd 5622 1 A a DT cord-010119-t1x9gknd 5622 2 high high JJ cord-010119-t1x9gknd 5622 3 proportion proportion NN cord-010119-t1x9gknd 5622 4 of of IN cord-010119-t1x9gknd 5622 5 HIV HIV NNP cord-010119-t1x9gknd 5622 6 positive positive JJ cord-010119-t1x9gknd 5622 7 women woman NNS cord-010119-t1x9gknd 5622 8 were be VBD cord-010119-t1x9gknd 5622 9 receiving receive VBG cord-010119-t1x9gknd 5622 10 ART art NN cord-010119-t1x9gknd 5622 11 , , , cord-010119-t1x9gknd 5622 12 consistent consistent JJ cord-010119-t1x9gknd 5622 13 with with IN cord-010119-t1x9gknd 5622 14 national national JJ cord-010119-t1x9gknd 5622 15 guidelines guideline NNS cord-010119-t1x9gknd 5622 16 . . . cord-010119-t1x9gknd 5623 1 Future future JJ cord-010119-t1x9gknd 5623 2 studies study NNS cord-010119-t1x9gknd 5623 3 will will MD cord-010119-t1x9gknd 5623 4 examine examine VB cord-010119-t1x9gknd 5623 5 longer long JJR cord-010119-t1x9gknd 5623 6 - - HYPH cord-010119-t1x9gknd 5623 7 term term NN cord-010119-t1x9gknd 5623 8 responses response NNS cord-010119-t1x9gknd 5623 9 to to IN cord-010119-t1x9gknd 5623 10 iron iron NN cord-010119-t1x9gknd 5623 11 therapy therapy NN cord-010119-t1x9gknd 5623 12 to to TO cord-010119-t1x9gknd 5623 13 assess assess VB cord-010119-t1x9gknd 5623 14 its -PRON- PRP$ cord-010119-t1x9gknd 5623 15 potential potential NN cord-010119-t1x9gknd 5623 16 in in IN cord-010119-t1x9gknd 5623 17 decreasing decrease VBG cord-010119-t1x9gknd 5623 18 the the DT cord-010119-t1x9gknd 5623 19 incidence incidence NN cord-010119-t1x9gknd 5623 20 of of IN cord-010119-t1x9gknd 5623 21 peripartum peripartum NN cord-010119-t1x9gknd 5623 22 blood blood NN cord-010119-t1x9gknd 5623 23 transfusion transfusion NN cord-010119-t1x9gknd 5623 24 . . . cord-010119-t1x9gknd 5624 1 Background Background NNP cord-010119-t1x9gknd 5624 2 / / SYM cord-010119-t1x9gknd 5624 3 Case Case NNP cord-010119-t1x9gknd 5624 4 Studies Studies NNPS cord-010119-t1x9gknd 5624 5 : : : cord-010119-t1x9gknd 5625 1 A a DT cord-010119-t1x9gknd 5625 2 2 2 CD cord-010119-t1x9gknd 5625 3 month month NN cord-010119-t1x9gknd 5625 4 old old JJ cord-010119-t1x9gknd 5625 5 boy boy NN cord-010119-t1x9gknd 5625 6 presented present VBN cord-010119-t1x9gknd 5625 7 to to IN cord-010119-t1x9gknd 5625 8 our -PRON- PRP$ cord-010119-t1x9gknd 5625 9 institution institution NN cord-010119-t1x9gknd 5625 10 after after IN cord-010119-t1x9gknd 5625 11 a a DT cord-010119-t1x9gknd 5625 12 1 1 CD cord-010119-t1x9gknd 5625 13 month month NN cord-010119-t1x9gknd 5625 14 hospitalization hospitalization NN cord-010119-t1x9gknd 5625 15 in in IN cord-010119-t1x9gknd 5625 16 Japan Japan NNP cord-010119-t1x9gknd 5625 17 . . . cord-010119-t1x9gknd 5626 1 He -PRON- PRP cord-010119-t1x9gknd 5626 2 was be VBD cord-010119-t1x9gknd 5626 3 admitted admit VBN cord-010119-t1x9gknd 5626 4 there there RB cord-010119-t1x9gknd 5626 5 , , , cord-010119-t1x9gknd 5626 6 several several JJ cord-010119-t1x9gknd 5626 7 weeks week NNS cord-010119-t1x9gknd 5626 8 after after IN cord-010119-t1x9gknd 5626 9 his -PRON- PRP$ cord-010119-t1x9gknd 5626 10 unremarkable unremarkable JJ cord-010119-t1x9gknd 5626 11 term term NN cord-010119-t1x9gknd 5626 12 birth birth NN cord-010119-t1x9gknd 5626 13 to to IN cord-010119-t1x9gknd 5626 14 an an DT cord-010119-t1x9gknd 5626 15 AB AB NNP cord-010119-t1x9gknd 5626 16 Rh Rh NNP cord-010119-t1x9gknd 5626 17 positive positive JJ cord-010119-t1x9gknd 5626 18 woman woman NN cord-010119-t1x9gknd 5626 19 , , , cord-010119-t1x9gknd 5626 20 with with IN cord-010119-t1x9gknd 5626 21 lethargy lethargy NN cord-010119-t1x9gknd 5626 22 , , , cord-010119-t1x9gknd 5626 23 failure failure NN cord-010119-t1x9gknd 5626 24 to to TO cord-010119-t1x9gknd 5626 25 thrive thrive VB cord-010119-t1x9gknd 5626 26 , , , cord-010119-t1x9gknd 5626 27 bloody bloody JJ cord-010119-t1x9gknd 5626 28 mucoid mucoid JJ cord-010119-t1x9gknd 5626 29 stools stool NNS cord-010119-t1x9gknd 5626 30 with with IN cord-010119-t1x9gknd 5626 31 eosinophilia eosinophilia NN cord-010119-t1x9gknd 5626 32 , , , cord-010119-t1x9gknd 5626 33 and and CC cord-010119-t1x9gknd 5626 34 an an DT cord-010119-t1x9gknd 5626 35 elevated elevated JJ cord-010119-t1x9gknd 5626 36 serum serum NN cord-010119-t1x9gknd 5626 37 white white JJ cord-010119-t1x9gknd 5626 38 count count NN cord-010119-t1x9gknd 5626 39 . . . cord-010119-t1x9gknd 5627 1 He -PRON- PRP cord-010119-t1x9gknd 5627 2 was be VBD cord-010119-t1x9gknd 5627 3 found find VBN cord-010119-t1x9gknd 5627 4 to to TO cord-010119-t1x9gknd 5627 5 be be VB cord-010119-t1x9gknd 5627 6 anemic anemic JJ cord-010119-t1x9gknd 5627 7 and and CC cord-010119-t1x9gknd 5627 8 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 5627 9 and and CC cord-010119-t1x9gknd 5627 10 required require VBD cord-010119-t1x9gknd 5627 11 multiple multiple JJ cord-010119-t1x9gknd 5627 12 transfusions transfusion NNS cord-010119-t1x9gknd 5627 13 . . . cord-010119-t1x9gknd 5628 1 Also also RB cord-010119-t1x9gknd 5628 2 , , , cord-010119-t1x9gknd 5628 3 he -PRON- PRP cord-010119-t1x9gknd 5628 4 had have VBD cord-010119-t1x9gknd 5628 5 a a DT cord-010119-t1x9gknd 5628 6 diffuse diffuse NN cord-010119-t1x9gknd 5628 7 , , , cord-010119-t1x9gknd 5628 8 scaling scale VBG cord-010119-t1x9gknd 5628 9 , , , cord-010119-t1x9gknd 5628 10 erythematous erythematous JJ cord-010119-t1x9gknd 5628 11 rash rash NN cord-010119-t1x9gknd 5628 12 over over IN cord-010119-t1x9gknd 5628 13 his -PRON- PRP$ cord-010119-t1x9gknd 5628 14 inner inner JJ cord-010119-t1x9gknd 5628 15 thighs thigh NNS cord-010119-t1x9gknd 5628 16 . . . cord-010119-t1x9gknd 5629 1 Study Study NNP cord-010119-t1x9gknd 5629 2 Design Design NNP cord-010119-t1x9gknd 5629 3 / / SYM cord-010119-t1x9gknd 5629 4 Method method NN cord-010119-t1x9gknd 5629 5 : : : cord-010119-t1x9gknd 5630 1 Initial initial JJ cord-010119-t1x9gknd 5630 2 workup workup NN cord-010119-t1x9gknd 5630 3 was be VBD cord-010119-t1x9gknd 5630 4 suspicous suspicous JJ cord-010119-t1x9gknd 5630 5 for for IN cord-010119-t1x9gknd 5630 6 an an DT cord-010119-t1x9gknd 5630 7 allergic allergic JJ cord-010119-t1x9gknd 5630 8 / / SYM cord-010119-t1x9gknd 5630 9 necrotizing necrotize VBG cord-010119-t1x9gknd 5630 10 enterocolitis enterocolitis NN cord-010119-t1x9gknd 5630 11 . . . cord-010119-t1x9gknd 5631 1 The the DT cord-010119-t1x9gknd 5631 2 patient patient NN cord-010119-t1x9gknd 5631 3 had have VBD cord-010119-t1x9gknd 5631 4 an an DT cord-010119-t1x9gknd 5631 5 elevated elevated JJ cord-010119-t1x9gknd 5631 6 LDH ldh NN cord-010119-t1x9gknd 5631 7 and and CC cord-010119-t1x9gknd 5631 8 potassium potassium NN cord-010119-t1x9gknd 5631 9 , , , cord-010119-t1x9gknd 5631 10 and and CC cord-010119-t1x9gknd 5631 11 concern concern NN cord-010119-t1x9gknd 5631 12 was be VBD cord-010119-t1x9gknd 5631 13 raised raise VBN cord-010119-t1x9gknd 5631 14 for for IN cord-010119-t1x9gknd 5631 15 leukemia leukemia NN cord-010119-t1x9gknd 5631 16 with with IN cord-010119-t1x9gknd 5631 17 possible possible JJ cord-010119-t1x9gknd 5631 18 tumor tumor NN cord-010119-t1x9gknd 5631 19 lysis lysis NN cord-010119-t1x9gknd 5631 20 syndrome syndrome NN cord-010119-t1x9gknd 5631 21 . . . cord-010119-t1x9gknd 5632 1 A a DT cord-010119-t1x9gknd 5632 2 sample sample NN cord-010119-t1x9gknd 5632 3 sent send VBN cord-010119-t1x9gknd 5632 4 to to IN cord-010119-t1x9gknd 5632 5 our -PRON- PRP$ cord-010119-t1x9gknd 5632 6 blood blood NN cord-010119-t1x9gknd 5632 7 bank bank NN cord-010119-t1x9gknd 5632 8 showed show VBD cord-010119-t1x9gknd 5632 9 an an DT cord-010119-t1x9gknd 5632 10 anti anti JJ cord-010119-t1x9gknd 5632 11 - - JJ cord-010119-t1x9gknd 5632 12 E e JJ cord-010119-t1x9gknd 5632 13 , , , cord-010119-t1x9gknd 5632 14 with with IN cord-010119-t1x9gknd 5632 15 a a DT cord-010119-t1x9gknd 5632 16 positive positive JJ cord-010119-t1x9gknd 5632 17 DAT DAT NNP cord-010119-t1x9gknd 5632 18 ( ( -LRB- cord-010119-t1x9gknd 5632 19 IgG igg NN cord-010119-t1x9gknd 5632 20 and and CC cord-010119-t1x9gknd 5632 21 complement complement NN cord-010119-t1x9gknd 5632 22 ) ) -RRB- cord-010119-t1x9gknd 5632 23 , , , cord-010119-t1x9gknd 5632 24 and and CC cord-010119-t1x9gknd 5632 25 was be VBD cord-010119-t1x9gknd 5632 26 positive positive JJ cord-010119-t1x9gknd 5632 27 for for IN cord-010119-t1x9gknd 5632 28 E e NN cord-010119-t1x9gknd 5632 29 , , , cord-010119-t1x9gknd 5632 30 e e NN cord-010119-t1x9gknd 5632 31 , , , cord-010119-t1x9gknd 5632 32 and and CC cord-010119-t1x9gknd 5632 33 C C NNP cord-010119-t1x9gknd 5632 34 antigens antigen NNS cord-010119-t1x9gknd 5632 35 . . . cord-010119-t1x9gknd 5633 1 Concern concern NN cord-010119-t1x9gknd 5633 2 for for IN cord-010119-t1x9gknd 5633 3 a a DT cord-010119-t1x9gknd 5633 4 maternally maternally RB cord-010119-t1x9gknd 5633 5 - - HYPH cord-010119-t1x9gknd 5633 6 induced induce VBN cord-010119-t1x9gknd 5633 7 antibody antibody NN cord-010119-t1x9gknd 5633 8 was be VBD cord-010119-t1x9gknd 5633 9 raised raise VBN cord-010119-t1x9gknd 5633 10 , , , cord-010119-t1x9gknd 5633 11 as as IN cord-010119-t1x9gknd 5633 12 was be VBD cord-010119-t1x9gknd 5633 13 the the DT cord-010119-t1x9gknd 5633 14 possibility possibility NN cord-010119-t1x9gknd 5633 15 of of IN cord-010119-t1x9gknd 5633 16 a a DT cord-010119-t1x9gknd 5633 17 red red JJ cord-010119-t1x9gknd 5633 18 cell cell NN cord-010119-t1x9gknd 5633 19 antigen antigen NN cord-010119-t1x9gknd 5633 20 passively passively RB cord-010119-t1x9gknd 5633 21 transfused transfuse VBN cord-010119-t1x9gknd 5633 22 from from IN cord-010119-t1x9gknd 5633 23 blood blood NN cord-010119-t1x9gknd 5633 24 products product NNS cord-010119-t1x9gknd 5633 25 administered administer VBN cord-010119-t1x9gknd 5633 26 at at IN cord-010119-t1x9gknd 5633 27 the the DT cord-010119-t1x9gknd 5633 28 Japanese japanese JJ cord-010119-t1x9gknd 5633 29 hospital hospital NN cord-010119-t1x9gknd 5633 30 ; ; : cord-010119-t1x9gknd 5633 31 both both DT cord-010119-t1x9gknd 5633 32 possibilities possibility NNS cord-010119-t1x9gknd 5633 33 were be VBD cord-010119-t1x9gknd 5633 34 excluded exclude VBN cord-010119-t1x9gknd 5633 35 . . . cord-010119-t1x9gknd 5634 1 Further further JJ cord-010119-t1x9gknd 5634 2 workup workup NN cord-010119-t1x9gknd 5634 3 revealed reveal VBD cord-010119-t1x9gknd 5634 4 no no DT cord-010119-t1x9gknd 5634 5 infection infection NN cord-010119-t1x9gknd 5634 6 or or CC cord-010119-t1x9gknd 5634 7 hematologic hematologic JJ cord-010119-t1x9gknd 5634 8 proliferation proliferation NN cord-010119-t1x9gknd 5634 9 . . . cord-010119-t1x9gknd 5635 1 Biopsy biopsy NN cord-010119-t1x9gknd 5635 2 of of IN cord-010119-t1x9gknd 5635 3 his -PRON- PRP$ cord-010119-t1x9gknd 5635 4 rash rash NN cord-010119-t1x9gknd 5635 5 showed show VBD cord-010119-t1x9gknd 5635 6 spongiotic spongiotic JJ cord-010119-t1x9gknd 5635 7 dermatitis dermatitis NN cord-010119-t1x9gknd 5635 8 . . . cord-010119-t1x9gknd 5636 1 His -PRON- PRP$ cord-010119-t1x9gknd 5636 2 clinical clinical JJ cord-010119-t1x9gknd 5636 3 course course NN cord-010119-t1x9gknd 5636 4 deteriorated deteriorate VBD cord-010119-t1x9gknd 5636 5 , , , cord-010119-t1x9gknd 5636 6 and and CC cord-010119-t1x9gknd 5636 7 he -PRON- PRP cord-010119-t1x9gknd 5636 8 developed develop VBD cord-010119-t1x9gknd 5636 9 hepatomegaly hepatomegaly NNP cord-010119-t1x9gknd 5636 10 and and CC cord-010119-t1x9gknd 5636 11 jaundice jaundice NN cord-010119-t1x9gknd 5636 12 . . . cord-010119-t1x9gknd 5637 1 A a DT cord-010119-t1x9gknd 5637 2 concern concern NN cord-010119-t1x9gknd 5637 3 for for IN cord-010119-t1x9gknd 5637 4 Wiskott Wiskott NNP cord-010119-t1x9gknd 5637 5 - - HYPH cord-010119-t1x9gknd 5637 6 Aldrich Aldrich NNP cord-010119-t1x9gknd 5637 7 syndrome syndrome NN cord-010119-t1x9gknd 5637 8 was be VBD cord-010119-t1x9gknd 5637 9 raised raise VBN cord-010119-t1x9gknd 5637 10 , , , cord-010119-t1x9gknd 5637 11 and and CC cord-010119-t1x9gknd 5637 12 workup workup NN cord-010119-t1x9gknd 5637 13 showed show VBD cord-010119-t1x9gknd 5637 14 normal normal JJ cord-010119-t1x9gknd 5637 15 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 5637 16 levels level NNS cord-010119-t1x9gknd 5637 17 , , , cord-010119-t1x9gknd 5637 18 but but CC cord-010119-t1x9gknd 5637 19 with with IN cord-010119-t1x9gknd 5637 20 elevated elevated JJ cord-010119-t1x9gknd 5637 21 IgE IgE NNP cord-010119-t1x9gknd 5637 22 ( ( -LRB- cord-010119-t1x9gknd 5637 23 15270 15270 CD cord-010119-t1x9gknd 5637 24 kU kU NNP cord-010119-t1x9gknd 5637 25 / / SYM cord-010119-t1x9gknd 5637 26 L l NN cord-010119-t1x9gknd 5637 27 ; ; : cord-010119-t1x9gknd 5637 28 RR rr NN cord-010119-t1x9gknd 5637 29 : : : cord-010119-t1x9gknd 5637 30 0 0 CD cord-010119-t1x9gknd 5637 31 - - HYPH cord-010119-t1x9gknd 5637 32 2.9 2.9 CD cord-010119-t1x9gknd 5637 33 ) ) -RRB- cord-010119-t1x9gknd 5637 34 . . . cord-010119-t1x9gknd 5638 1 Anti anti JJ cord-010119-t1x9gknd 5638 2 - - JJ cord-010119-t1x9gknd 5638 3 platelet platelet JJ cord-010119-t1x9gknd 5638 4 antibodies antibody NNS cord-010119-t1x9gknd 5638 5 were be VBD cord-010119-t1x9gknd 5638 6 identified identify VBN cord-010119-t1x9gknd 5638 7 . . . cord-010119-t1x9gknd 5639 1 Three three CD cord-010119-t1x9gknd 5639 2 days day NNS cord-010119-t1x9gknd 5639 3 after after IN cord-010119-t1x9gknd 5639 4 admission admission NN cord-010119-t1x9gknd 5639 5 , , , cord-010119-t1x9gknd 5639 6 testing testing NN cord-010119-t1x9gknd 5639 7 was be VBD cord-010119-t1x9gknd 5639 8 sent send VBN cord-010119-t1x9gknd 5639 9 for for IN cord-010119-t1x9gknd 5639 10 genetic genetic JJ cord-010119-t1x9gknd 5639 11 alterations alteration NNS cord-010119-t1x9gknd 5639 12 of of IN cord-010119-t1x9gknd 5639 13 FOXP3 FOXP3 NNS cord-010119-t1x9gknd 5639 14 , , , cord-010119-t1x9gknd 5639 15 while while IN cord-010119-t1x9gknd 5639 16 a a DT cord-010119-t1x9gknd 5639 17 Japanese Japanese NNP cord-010119-t1x9gknd 5639 18 - - HYPH cord-010119-t1x9gknd 5639 19 speaking speak VBG cord-010119-t1x9gknd 5639 20 physician physician NN cord-010119-t1x9gknd 5639 21 at at IN cord-010119-t1x9gknd 5639 22 our -PRON- PRP$ cord-010119-t1x9gknd 5639 23 institution institution NN cord-010119-t1x9gknd 5639 24 read read VBD cord-010119-t1x9gknd 5639 25 a a DT cord-010119-t1x9gknd 5639 26 prior prior JJ cord-010119-t1x9gknd 5639 27 flow flow NN cord-010119-t1x9gknd 5639 28 cytometry cytometry NN cord-010119-t1x9gknd 5639 29 study study NN cord-010119-t1x9gknd 5639 30 showing show VBG cord-010119-t1x9gknd 5639 31 a a DT cord-010119-t1x9gknd 5639 32 deficiency deficiency NN cord-010119-t1x9gknd 5639 33 of of IN cord-010119-t1x9gknd 5639 34 FOXP31 FOXP31 NNP cord-010119-t1x9gknd 5639 35 CD41 CD41 NNP cord-010119-t1x9gknd 5639 36 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 5639 37 . . . cord-010119-t1x9gknd 5640 1 The the DT cord-010119-t1x9gknd 5640 2 majority majority NN cord-010119-t1x9gknd 5640 3 of of IN cord-010119-t1x9gknd 5640 4 these these DT cord-010119-t1x9gknd 5640 5 indications indication NNS cord-010119-t1x9gknd 5640 6 are be VBP cord-010119-t1x9gknd 5640 7 seen see VBN cord-010119-t1x9gknd 5640 8 in in IN cord-010119-t1x9gknd 5640 9 adults adult NNS cord-010119-t1x9gknd 5640 10 and and CC cord-010119-t1x9gknd 5640 11 for for IN cord-010119-t1x9gknd 5640 12 which which WDT cord-010119-t1x9gknd 5640 13 a a DT cord-010119-t1x9gknd 5640 14 reported report VBN cord-010119-t1x9gknd 5640 15 plasma plasma NN cord-010119-t1x9gknd 5640 16 wastage wastage NN cord-010119-t1x9gknd 5640 17 is be VBZ cord-010119-t1x9gknd 5640 18 $ $ $ cord-010119-t1x9gknd 5640 19 1.8 1.8 CD cord-010119-t1x9gknd 5640 20 % % NN cord-010119-t1x9gknd 5640 21 . . . cord-010119-t1x9gknd 5641 1 Fortunately fortunately RB cord-010119-t1x9gknd 5641 2 in in IN cord-010119-t1x9gknd 5641 3 pediatrics pediatric NNS cord-010119-t1x9gknd 5641 4 the the DT cord-010119-t1x9gknd 5641 5 incidence incidence NN cord-010119-t1x9gknd 5641 6 of of IN cord-010119-t1x9gknd 5641 7 these these DT cord-010119-t1x9gknd 5641 8 indications indication NNS cord-010119-t1x9gknd 5641 9 is be VBZ cord-010119-t1x9gknd 5641 10 low low JJ cord-010119-t1x9gknd 5641 11 despite despite IN cord-010119-t1x9gknd 5641 12 the the DT cord-010119-t1x9gknd 5641 13 heterogeneity heterogeneity NN cord-010119-t1x9gknd 5641 14 of of IN cord-010119-t1x9gknd 5641 15 the the DT cord-010119-t1x9gknd 5641 16 patient patient JJ cord-010119-t1x9gknd 5641 17 population population NN cord-010119-t1x9gknd 5641 18 . . . cord-010119-t1x9gknd 5642 1 During during IN cord-010119-t1x9gknd 5642 2 the the DT cord-010119-t1x9gknd 5642 3 utilization utilization NN cord-010119-t1x9gknd 5642 4 review review NN cord-010119-t1x9gknd 5642 5 process process NN cord-010119-t1x9gknd 5642 6 at at IN cord-010119-t1x9gknd 5642 7 our -PRON- PRP$ cord-010119-t1x9gknd 5642 8 primary primary JJ cord-010119-t1x9gknd 5642 9 pediatric pediatric JJ cord-010119-t1x9gknd 5642 10 institution institution NN cord-010119-t1x9gknd 5642 11 , , , cord-010119-t1x9gknd 5642 12 we -PRON- PRP cord-010119-t1x9gknd 5642 13 noted note VBD cord-010119-t1x9gknd 5642 14 a a DT cord-010119-t1x9gknd 5642 15 mean mean JJ cord-010119-t1x9gknd 5642 16 wastage wastage NN cord-010119-t1x9gknd 5642 17 of of IN cord-010119-t1x9gknd 5642 18 8.2 8.2 CD cord-010119-t1x9gknd 5642 19 % % NN cord-010119-t1x9gknd 5642 20 over over IN cord-010119-t1x9gknd 5642 21 the the DT cord-010119-t1x9gknd 5642 22 last last JJ cord-010119-t1x9gknd 5642 23 5 5 CD cord-010119-t1x9gknd 5642 24 years year NNS cord-010119-t1x9gknd 5642 25 . . . cord-010119-t1x9gknd 5643 1 With with IN cord-010119-t1x9gknd 5643 2 recent recent JJ cord-010119-t1x9gknd 5643 3 changes change NNS cord-010119-t1x9gknd 5643 4 in in IN cord-010119-t1x9gknd 5643 5 clinical clinical JJ cord-010119-t1x9gknd 5643 6 practice practice NN cord-010119-t1x9gknd 5643 7 ( ( -LRB- cord-010119-t1x9gknd 5643 8 liver liver NN cord-010119-t1x9gknd 5643 9 transplants transplant NNS cord-010119-t1x9gknd 5643 10 and and CC cord-010119-t1x9gknd 5643 11 increased increase VBN cord-010119-t1x9gknd 5643 12 trauma trauma NN cord-010119-t1x9gknd 5643 13 ) ) -RRB- cord-010119-t1x9gknd 5643 14 and and CC cord-010119-t1x9gknd 5643 15 recent recent JJ cord-010119-t1x9gknd 5643 16 evidence evidence NN cord-010119-t1x9gknd 5643 17 that that IN cord-010119-t1x9gknd 5643 18 faster fast JJR cord-010119-t1x9gknd 5643 19 plasma plasma NN cord-010119-t1x9gknd 5643 20 improves improve VBZ cord-010119-t1x9gknd 5643 21 massive massive JJ cord-010119-t1x9gknd 5643 22 transfusion transfusion NN cord-010119-t1x9gknd 5643 23 protocol protocol NN cord-010119-t1x9gknd 5643 24 ( ( -LRB- cord-010119-t1x9gknd 5643 25 MTP MTP NNP cord-010119-t1x9gknd 5643 26 ) ) -RRB- cord-010119-t1x9gknd 5643 27 outcomes outcome NNS cord-010119-t1x9gknd 5643 28 , , , cord-010119-t1x9gknd 5643 29 our -PRON- PRP$ cord-010119-t1x9gknd 5643 30 facility facility NN cord-010119-t1x9gknd 5643 31 decided decide VBD cord-010119-t1x9gknd 5643 32 to to TO cord-010119-t1x9gknd 5643 33 implement implement VB cord-010119-t1x9gknd 5643 34 the the DT cord-010119-t1x9gknd 5643 35 use use NN cord-010119-t1x9gknd 5643 36 of of IN cord-010119-t1x9gknd 5643 37 thawed thawed JJ cord-010119-t1x9gknd 5643 38 plasma plasma NN cord-010119-t1x9gknd 5643 39 and and CC cord-010119-t1x9gknd 5643 40 benchmark benchmark JJ cord-010119-t1x9gknd 5643 41 MTP MTP NNP cord-010119-t1x9gknd 5643 42 plasma plasma NN cord-010119-t1x9gknd 5643 43 wastage wastage NN cord-010119-t1x9gknd 5643 44 . . . cord-010119-t1x9gknd 5644 1 Study Study NNP cord-010119-t1x9gknd 5644 2 Design Design NNP cord-010119-t1x9gknd 5644 3 / / SYM cord-010119-t1x9gknd 5644 4 Method method NN cord-010119-t1x9gknd 5644 5 : : : cord-010119-t1x9gknd 5645 1 Blood blood NN cord-010119-t1x9gknd 5645 2 Utilization Utilization NNP cord-010119-t1x9gknd 5645 3 Review Review NNP cord-010119-t1x9gknd 5645 4 revealed reveal VBD cord-010119-t1x9gknd 5645 5 an an DT cord-010119-t1x9gknd 5645 6 increase increase NN cord-010119-t1x9gknd 5645 7 in in IN cord-010119-t1x9gknd 5645 8 the the DT cord-010119-t1x9gknd 5645 9 overall overall JJ cord-010119-t1x9gknd 5645 10 percentage percentage NN cord-010119-t1x9gknd 5645 11 of of IN cord-010119-t1x9gknd 5645 12 plasma plasma NN cord-010119-t1x9gknd 5645 13 wastage wastage NN cord-010119-t1x9gknd 5645 14 from from IN cord-010119-t1x9gknd 5645 15 2014 2014 CD cord-010119-t1x9gknd 5645 16 to to IN cord-010119-t1x9gknd 5645 17 2016 2016 CD cord-010119-t1x9gknd 5645 18 , , , cord-010119-t1x9gknd 5645 19 with with IN cord-010119-t1x9gknd 5645 20 a a DT cord-010119-t1x9gknd 5645 21 peak peak NN cord-010119-t1x9gknd 5645 22 of of IN cord-010119-t1x9gknd 5645 23 11.6 11.6 CD cord-010119-t1x9gknd 5645 24 % % NN cord-010119-t1x9gknd 5645 25 ( ( -LRB- cord-010119-t1x9gknd 5645 26 range range NN cord-010119-t1x9gknd 5645 27 3.2%-11.6 3.2%-11.6 CD cord-010119-t1x9gknd 5645 28 % % NN cord-010119-t1x9gknd 5645 29 ) ) -RRB- cord-010119-t1x9gknd 5645 30 . . . cord-010119-t1x9gknd 5646 1 A a DT cord-010119-t1x9gknd 5646 2 single single JJ cord-010119-t1x9gknd 5646 3 cause cause NN cord-010119-t1x9gknd 5646 4 could could MD cord-010119-t1x9gknd 5646 5 not not RB cord-010119-t1x9gknd 5646 6 be be VB cord-010119-t1x9gknd 5646 7 readily readily RB cord-010119-t1x9gknd 5646 8 identified identify VBN cord-010119-t1x9gknd 5646 9 prompting prompt VBG cord-010119-t1x9gknd 5646 10 us -PRON- PRP cord-010119-t1x9gknd 5646 11 to to TO cord-010119-t1x9gknd 5646 12 query query VB cord-010119-t1x9gknd 5646 13 Children Children NNP cord-010119-t1x9gknd 5646 14 's 's POS cord-010119-t1x9gknd 5646 15 Hospital Hospital NNP cord-010119-t1x9gknd 5646 16 Association Association NNP cord-010119-t1x9gknd 5646 17 ( ( -LRB- cord-010119-t1x9gknd 5646 18 CHA CHA NNP cord-010119-t1x9gknd 5646 19 ) ) -RRB- cord-010119-t1x9gknd 5646 20 , , , cord-010119-t1x9gknd 5646 21 as as IN cord-010119-t1x9gknd 5646 22 our -PRON- PRP$ cord-010119-t1x9gknd 5646 23 initial initial JJ cord-010119-t1x9gknd 5646 24 external external JJ cord-010119-t1x9gknd 5646 25 pediatric pediatric JJ cord-010119-t1x9gknd 5646 26 benchmarking benchmarking NN cord-010119-t1x9gknd 5646 27 , , , cord-010119-t1x9gknd 5646 28 to to TO cord-010119-t1x9gknd 5646 29 determine determine VB cord-010119-t1x9gknd 5646 30 if if IN cord-010119-t1x9gknd 5646 31 our -PRON- PRP$ cord-010119-t1x9gknd 5646 32 wastage wastage NN cord-010119-t1x9gknd 5646 33 was be VBD cord-010119-t1x9gknd 5646 34 comparable comparable JJ cord-010119-t1x9gknd 5646 35 to to IN cord-010119-t1x9gknd 5646 36 other other JJ cord-010119-t1x9gknd 5646 37 children child NNS cord-010119-t1x9gknd 5646 38 's 's POS cord-010119-t1x9gknd 5646 39 hospitals hospital NNS cord-010119-t1x9gknd 5646 40 in in IN cord-010119-t1x9gknd 5646 41 addition addition NN cord-010119-t1x9gknd 5646 42 to to IN cord-010119-t1x9gknd 5646 43 reviewing review VBG cord-010119-t1x9gknd 5646 44 our -PRON- PRP$ cord-010119-t1x9gknd 5646 45 " " `` cord-010119-t1x9gknd 5646 46 time time NN cord-010119-t1x9gknd 5646 47 of of IN cord-010119-t1x9gknd 5646 48 plasma plasma NN cord-010119-t1x9gknd 5646 49 availability availability NN cord-010119-t1x9gknd 5646 50 " " '' cord-010119-t1x9gknd 5646 51 for for IN cord-010119-t1x9gknd 5646 52 2016 2016 CD cord-010119-t1x9gknd 5646 53 MTPS MTPS NNP cord-010119-t1x9gknd 5646 54 . . . cord-010119-t1x9gknd 5647 1 Results/ Results/ . cord-010119-t1x9gknd 5648 1 Finding finding NN cord-010119-t1x9gknd 5648 2 : : : cord-010119-t1x9gknd 5649 1 In in IN cord-010119-t1x9gknd 5649 2 2016 2016 CD cord-010119-t1x9gknd 5649 3 , , , cord-010119-t1x9gknd 5649 4 MTP MTP NNP cord-010119-t1x9gknd 5649 5 was be VBD cord-010119-t1x9gknd 5649 6 activated activate VBN cord-010119-t1x9gknd 5649 7 28 28 CD cord-010119-t1x9gknd 5649 8 times time NNS cord-010119-t1x9gknd 5649 9 . . . cord-010119-t1x9gknd 5650 1 In in IN cord-010119-t1x9gknd 5650 2 6 6 CD cord-010119-t1x9gknd 5650 3 cases case NNS cord-010119-t1x9gknd 5650 4 the the DT cord-010119-t1x9gknd 5650 5 patient patient NN cord-010119-t1x9gknd 5650 6 did do VBD cord-010119-t1x9gknd 5650 7 not not RB cord-010119-t1x9gknd 5650 8 receive receive VB cord-010119-t1x9gknd 5650 9 any any DT cord-010119-t1x9gknd 5650 10 blood blood NN cord-010119-t1x9gknd 5650 11 product product NN cord-010119-t1x9gknd 5650 12 and and CC cord-010119-t1x9gknd 5650 13 in in IN cord-010119-t1x9gknd 5650 14 11 11 CD cord-010119-t1x9gknd 5650 15 cases case NNS cord-010119-t1x9gknd 5650 16 plasma plasma NN cord-010119-t1x9gknd 5650 17 was be VBD cord-010119-t1x9gknd 5650 18 already already RB cord-010119-t1x9gknd 5650 19 available available JJ cord-010119-t1x9gknd 5650 20 at at IN cord-010119-t1x9gknd 5650 21 the the DT cord-010119-t1x9gknd 5650 22 time time NN cord-010119-t1x9gknd 5650 23 of of IN cord-010119-t1x9gknd 5650 24 RBC RBC NNP cord-010119-t1x9gknd 5650 25 allocation allocation NN cord-010119-t1x9gknd 5650 26 / / SYM cord-010119-t1x9gknd 5650 27 issue issue NN cord-010119-t1x9gknd 5650 28 . . . cord-010119-t1x9gknd 5651 1 This this DT cord-010119-t1x9gknd 5651 2 left leave VBD cord-010119-t1x9gknd 5651 3 11 11 CD cord-010119-t1x9gknd 5651 4 cases case NNS cord-010119-t1x9gknd 5651 5 to to TO cord-010119-t1x9gknd 5651 6 evaluate evaluate VB cord-010119-t1x9gknd 5651 7 . . . cord-010119-t1x9gknd 5652 1 The the DT cord-010119-t1x9gknd 5652 2 median median JJ cord-010119-t1x9gknd 5652 3 time time NN cord-010119-t1x9gknd 5652 4 to to IN cord-010119-t1x9gknd 5652 5 plasma plasma NN cord-010119-t1x9gknd 5652 6 availability availability NN cord-010119-t1x9gknd 5652 7 was be VBD cord-010119-t1x9gknd 5652 8 29 29 CD cord-010119-t1x9gknd 5652 9 minutes minute NNS cord-010119-t1x9gknd 5652 10 ( ( -LRB- cord-010119-t1x9gknd 5652 11 range range VBP cord-010119-t1x9gknd 5652 12 4 4 CD cord-010119-t1x9gknd 5652 13 minutes minute NNS cord-010119-t1x9gknd 5652 14 -61 -61 NN cord-010119-t1x9gknd 5652 15 minutes minute NNS cord-010119-t1x9gknd 5652 16 ) ) -RRB- cord-010119-t1x9gknd 5652 17 . . . cord-010119-t1x9gknd 5653 1 The the DT cord-010119-t1x9gknd 5653 2 mean mean JJ cord-010119-t1x9gknd 5653 3 plasma plasma NN cord-010119-t1x9gknd 5653 4 wastage wastage NN cord-010119-t1x9gknd 5653 5 for for IN cord-010119-t1x9gknd 5653 6 MTP MTP NNP cord-010119-t1x9gknd 5653 7 activations activation NNS cord-010119-t1x9gknd 5653 8 was be VBD cord-010119-t1x9gknd 5653 9 32 32 CD cord-010119-t1x9gknd 5653 10 % % NN cord-010119-t1x9gknd 5653 11 ( ( -LRB- cord-010119-t1x9gknd 5653 12 range range NN cord-010119-t1x9gknd 5653 13 0 0 CD cord-010119-t1x9gknd 5653 14 - - SYM cord-010119-t1x9gknd 5653 15 100 100 CD cord-010119-t1x9gknd 5653 16 % % NN cord-010119-t1x9gknd 5653 17 ) ) -RRB- cord-010119-t1x9gknd 5653 18 . . . cord-010119-t1x9gknd 5654 1 Of of IN cord-010119-t1x9gknd 5654 2 the the DT cord-010119-t1x9gknd 5654 3 9 9 CD cord-010119-t1x9gknd 5654 4 CHA CHA NNP cord-010119-t1x9gknd 5654 5 replies reply NNS cord-010119-t1x9gknd 5654 6 , , , cord-010119-t1x9gknd 5654 7 3 3 CD cord-010119-t1x9gknd 5654 8 were be VBD cord-010119-t1x9gknd 5654 9 using use VBG cord-010119-t1x9gknd 5654 10 thawed thaw VBN cord-010119-t1x9gknd 5654 11 plasma plasma NN cord-010119-t1x9gknd 5654 12 and and CC cord-010119-t1x9gknd 5654 13 their -PRON- PRP$ cord-010119-t1x9gknd 5654 14 wastage wastage NN cord-010119-t1x9gknd 5654 15 was be VBD cord-010119-t1x9gknd 5655 1 < < XX cord-010119-t1x9gknd 5655 2 /5 /5 . cord-010119-t1x9gknd 5656 1 5 5 CD cord-010119-t1x9gknd 5656 2 % % NN cord-010119-t1x9gknd 5656 3 . . . cord-010119-t1x9gknd 5657 1 Conclusion conclusion NN cord-010119-t1x9gknd 5657 2 : : : cord-010119-t1x9gknd 5658 1 Increasing increase VBG cord-010119-t1x9gknd 5658 2 clinical clinical JJ cord-010119-t1x9gknd 5658 3 evidence evidence NN cord-010119-t1x9gknd 5658 4 supports support VBZ cord-010119-t1x9gknd 5658 5 the the DT cord-010119-t1x9gknd 5658 6 prompt prompt JJ cord-010119-t1x9gknd 5658 7 transfusion transfusion NN cord-010119-t1x9gknd 5658 8 of of IN cord-010119-t1x9gknd 5658 9 plasma plasma NN cord-010119-t1x9gknd 5658 10 in in IN cord-010119-t1x9gknd 5658 11 the the DT cord-010119-t1x9gknd 5658 12 setting setting NN cord-010119-t1x9gknd 5658 13 of of IN cord-010119-t1x9gknd 5658 14 MTP MTP NNP cord-010119-t1x9gknd 5658 15 to to TO cord-010119-t1x9gknd 5658 16 decrease decrease VB cord-010119-t1x9gknd 5658 17 morbidity morbidity NN cord-010119-t1x9gknd 5658 18 and and CC cord-010119-t1x9gknd 5658 19 mortality mortality NN cord-010119-t1x9gknd 5658 20 . . . cord-010119-t1x9gknd 5659 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5659 2 brief brief JJ cord-010119-t1x9gknd 5659 3 review review NN cord-010119-t1x9gknd 5659 4 suggests suggest VBZ cord-010119-t1x9gknd 5659 5 that that IN cord-010119-t1x9gknd 5659 6 implementing implement VBG cord-010119-t1x9gknd 5659 7 thawed thawed JJ cord-010119-t1x9gknd 5659 8 plasma plasma NN cord-010119-t1x9gknd 5659 9 will will MD cord-010119-t1x9gknd 5659 10 allow allow VB cord-010119-t1x9gknd 5659 11 a a DT cord-010119-t1x9gknd 5659 12 potential potential JJ cord-010119-t1x9gknd 5659 13 decrease decrease NN cord-010119-t1x9gknd 5659 14 in in IN cord-010119-t1x9gknd 5659 15 plasma plasma NN cord-010119-t1x9gknd 5659 16 availability availability NN cord-010119-t1x9gknd 5659 17 of of IN cord-010119-t1x9gknd 5659 18 29 29 CD cord-010119-t1x9gknd 5659 19 minutes minute NNS cord-010119-t1x9gknd 5659 20 . . . cord-010119-t1x9gknd 5660 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5660 2 implementation implementation NN cord-010119-t1x9gknd 5660 3 began begin VBD cord-010119-t1x9gknd 5660 4 with with IN cord-010119-t1x9gknd 5660 5 thawing thaw VBG cord-010119-t1x9gknd 5660 6 a a DT cord-010119-t1x9gknd 5660 7 single single JJ cord-010119-t1x9gknd 5660 8 unit unit NN cord-010119-t1x9gknd 5660 9 of of IN cord-010119-t1x9gknd 5660 10 plasma plasma NN cord-010119-t1x9gknd 5660 11 for for IN cord-010119-t1x9gknd 5660 12 " " `` cord-010119-t1x9gknd 5660 13 Level Level NNP cord-010119-t1x9gknd 5660 14 1 1 CD cord-010119-t1x9gknd 5660 15 Neuro Neuro NNP cord-010119-t1x9gknd 5660 16 Trauma Trauma NNP cord-010119-t1x9gknd 5660 17 " " '' cord-010119-t1x9gknd 5660 18 alerts alert VBZ cord-010119-t1x9gknd 5660 19 , , , cord-010119-t1x9gknd 5660 20 and and CC cord-010119-t1x9gknd 5660 21 we -PRON- PRP cord-010119-t1x9gknd 5660 22 are be VBP cord-010119-t1x9gknd 5660 23 now now RB cord-010119-t1x9gknd 5660 24 keeping keep VBG cord-010119-t1x9gknd 5660 25 a a DT cord-010119-t1x9gknd 5660 26 single single JJ cord-010119-t1x9gknd 5660 27 unit unit NN cord-010119-t1x9gknd 5660 28 of of IN cord-010119-t1x9gknd 5660 29 AB AB NNP cord-010119-t1x9gknd 5660 30 plasma plasma NN cord-010119-t1x9gknd 5660 31 thawed thaw VBN cord-010119-t1x9gknd 5660 32 at at IN cord-010119-t1x9gknd 5660 33 all all DT cord-010119-t1x9gknd 5660 34 times time NNS cord-010119-t1x9gknd 5660 35 . . . cord-010119-t1x9gknd 5661 1 Plasma plasma NN cord-010119-t1x9gknd 5661 2 is be VBZ cord-010119-t1x9gknd 5661 3 now now RB cord-010119-t1x9gknd 5661 4 available available JJ cord-010119-t1x9gknd 5661 5 at at IN cord-010119-t1x9gknd 5661 6 the the DT cord-010119-t1x9gknd 5661 7 same same JJ cord-010119-t1x9gknd 5661 8 time time NN cord-010119-t1x9gknd 5661 9 as as IN cord-010119-t1x9gknd 5661 10 RBCs rbc NNS cord-010119-t1x9gknd 5661 11 thus thus RB cord-010119-t1x9gknd 5661 12 providing provide VBG cord-010119-t1x9gknd 5661 13 more more RBR cord-010119-t1x9gknd 5661 14 effective effective JJ cord-010119-t1x9gknd 5661 15 and and CC cord-010119-t1x9gknd 5661 16 balanced balanced JJ cord-010119-t1x9gknd 5661 17 blood blood NN cord-010119-t1x9gknd 5661 18 product product NN cord-010119-t1x9gknd 5661 19 support support NN cord-010119-t1x9gknd 5661 20 while while IN cord-010119-t1x9gknd 5661 21 reducing reduce VBG cord-010119-t1x9gknd 5661 22 wastage wastage NN cord-010119-t1x9gknd 5661 23 ( ( -LRB- cord-010119-t1x9gknd 5661 24 preliminary preliminary JJ cord-010119-t1x9gknd 5661 25 estimates estimate NNS cord-010119-t1x9gknd 5661 26 are be VBP cord-010119-t1x9gknd 5661 27 9.5 9.5 CD cord-010119-t1x9gknd 5661 28 % % NN cord-010119-t1x9gknd 5661 29 ) ) -RRB- cord-010119-t1x9gknd 5661 30 to to IN cord-010119-t1x9gknd 5661 31 a a DT cord-010119-t1x9gknd 5661 32 level level NN cord-010119-t1x9gknd 5661 33 consistent consistent JJ cord-010119-t1x9gknd 5661 34 with with IN cord-010119-t1x9gknd 5661 35 external external JJ cord-010119-t1x9gknd 5661 36 benchmarking benchmarking NN cord-010119-t1x9gknd 5661 37 . . . cord-010119-t1x9gknd 5662 1 Prospective prospective JJ cord-010119-t1x9gknd 5662 2 evaluation evaluation NN cord-010119-t1x9gknd 5662 3 of of IN cord-010119-t1x9gknd 5662 4 this this DT cord-010119-t1x9gknd 5662 5 practice practice NN cord-010119-t1x9gknd 5662 6 is be VBZ cord-010119-t1x9gknd 5662 7 ongoing ongoing JJ cord-010119-t1x9gknd 5662 8 at at IN cord-010119-t1x9gknd 5662 9 our -PRON- PRP$ cord-010119-t1x9gknd 5662 10 institution institution NN cord-010119-t1x9gknd 5662 11 and and CC cord-010119-t1x9gknd 5662 12 includes include VBZ cord-010119-t1x9gknd 5662 13 collaborative collaborative JJ cord-010119-t1x9gknd 5662 14 clinical clinical JJ cord-010119-t1x9gknd 5662 15 assessment assessment NN cord-010119-t1x9gknd 5662 16 with with IN cord-010119-t1x9gknd 5662 17 the the DT cord-010119-t1x9gknd 5662 18 Trauma Trauma NNP cord-010119-t1x9gknd 5662 19 Team Team NNP cord-010119-t1x9gknd 5662 20 . . . cord-010119-t1x9gknd 5663 1 Ultimately ultimately RB cord-010119-t1x9gknd 5663 2 prospective prospective JJ cord-010119-t1x9gknd 5663 3 , , , cord-010119-t1x9gknd 5663 4 multi multi JJ cord-010119-t1x9gknd 5663 5 - - JJ cord-010119-t1x9gknd 5663 6 institutional institutional JJ cord-010119-t1x9gknd 5663 7 studies study NNS cord-010119-t1x9gknd 5663 8 in in IN cord-010119-t1x9gknd 5663 9 pediatric pediatric JJ cord-010119-t1x9gknd 5663 10 institutions institution NNS cord-010119-t1x9gknd 5663 11 are be VBP cord-010119-t1x9gknd 5663 12 necessary necessary JJ cord-010119-t1x9gknd 5663 13 to to TO cord-010119-t1x9gknd 5663 14 define define VB cord-010119-t1x9gknd 5663 15 best good JJS cord-010119-t1x9gknd 5663 16 clinical clinical JJ cord-010119-t1x9gknd 5663 17 practice practice NN cord-010119-t1x9gknd 5663 18 and and CC cord-010119-t1x9gknd 5663 19 effectively effectively RB cord-010119-t1x9gknd 5663 20 benchmark benchmark JJ cord-010119-t1x9gknd 5663 21 blood blood NN cord-010119-t1x9gknd 5663 22 bank bank NN cord-010119-t1x9gknd 5663 23 practice practice NN cord-010119-t1x9gknd 5663 24 . . . cord-010119-t1x9gknd 5664 1 Background Background NNP cord-010119-t1x9gknd 5664 2 / / SYM cord-010119-t1x9gknd 5664 3 Case Case NNP cord-010119-t1x9gknd 5664 4 Studies Studies NNPS cord-010119-t1x9gknd 5664 5 : : : cord-010119-t1x9gknd 5664 6 Bacterial bacterial JJ cord-010119-t1x9gknd 5664 7 and and CC cord-010119-t1x9gknd 5664 8 fungal fungal JJ cord-010119-t1x9gknd 5664 9 infections infection NNS cord-010119-t1x9gknd 5664 10 remain remain VBP cord-010119-t1x9gknd 5664 11 a a DT cord-010119-t1x9gknd 5664 12 significant significant JJ cord-010119-t1x9gknd 5664 13 cause cause NN cord-010119-t1x9gknd 5664 14 of of IN cord-010119-t1x9gknd 5664 15 morbidity morbidity NN cord-010119-t1x9gknd 5664 16 and and CC cord-010119-t1x9gknd 5664 17 mortality mortality NN cord-010119-t1x9gknd 5664 18 in in IN cord-010119-t1x9gknd 5664 19 severely severely RB cord-010119-t1x9gknd 5664 20 neutropenic neutropenic JJ cord-010119-t1x9gknd 5664 21 patients patient NNS cord-010119-t1x9gknd 5664 22 with with IN cord-010119-t1x9gknd 5664 23 hematological hematological JJ cord-010119-t1x9gknd 5664 24 disease disease NN cord-010119-t1x9gknd 5664 25 receiving receive VBG cord-010119-t1x9gknd 5664 26 high high JJ cord-010119-t1x9gknd 5664 27 - - HYPH cord-010119-t1x9gknd 5664 28 dose dose NN cord-010119-t1x9gknd 5664 29 chemotherapy chemotherapy NN cord-010119-t1x9gknd 5664 30 and and CC cord-010119-t1x9gknd 5664 31 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 5664 32 stem stem NN cord-010119-t1x9gknd 5664 33 cell cell NN cord-010119-t1x9gknd 5664 34 transplantation transplantation NN cord-010119-t1x9gknd 5664 35 ( ( -LRB- cord-010119-t1x9gknd 5664 36 HSCT HSCT NNP cord-010119-t1x9gknd 5664 37 ) ) -RRB- cord-010119-t1x9gknd 5664 38 . . . cord-010119-t1x9gknd 5665 1 Granulocyte Granulocyte NNP cord-010119-t1x9gknd 5665 2 transfusions transfusion NNS cord-010119-t1x9gknd 5665 3 ( ( -LRB- cord-010119-t1x9gknd 5665 4 GTx GTx NNS cord-010119-t1x9gknd 5665 5 ) ) -RRB- cord-010119-t1x9gknd 5665 6 have have VBP cord-010119-t1x9gknd 5665 7 been be VBN cord-010119-t1x9gknd 5665 8 used use VBN cord-010119-t1x9gknd 5665 9 for for IN cord-010119-t1x9gknd 5665 10 over over IN cord-010119-t1x9gknd 5665 11 40 40 CD cord-010119-t1x9gknd 5665 12 years year NNS cord-010119-t1x9gknd 5665 13 , , , cord-010119-t1x9gknd 5665 14 although although IN cord-010119-t1x9gknd 5665 15 effectiveness effectiveness NN cord-010119-t1x9gknd 5665 16 , , , cord-010119-t1x9gknd 5665 17 indications indication NNS cord-010119-t1x9gknd 5665 18 , , , cord-010119-t1x9gknd 5665 19 and and CC cord-010119-t1x9gknd 5665 20 both both DT cord-010119-t1x9gknd 5665 21 patient patient JJ cord-010119-t1x9gknd 5665 22 and and CC cord-010119-t1x9gknd 5665 23 donor donor NN cord-010119-t1x9gknd 5665 24 safety safety NN cord-010119-t1x9gknd 5665 25 remain remain VBP cord-010119-t1x9gknd 5665 26 debated debate VBN cord-010119-t1x9gknd 5665 27 , , , cord-010119-t1x9gknd 5665 28 particularly particularly RB cord-010119-t1x9gknd 5665 29 in in IN cord-010119-t1x9gknd 5665 30 children child NNS cord-010119-t1x9gknd 5665 31 . . . cord-010119-t1x9gknd 5666 1 To to TO cord-010119-t1x9gknd 5666 2 contribute contribute VB cord-010119-t1x9gknd 5666 3 to to IN cord-010119-t1x9gknd 5666 4 this this DT cord-010119-t1x9gknd 5666 5 discussion discussion NN cord-010119-t1x9gknd 5666 6 we -PRON- PRP cord-010119-t1x9gknd 5666 7 demonstrated demonstrate VBD cord-010119-t1x9gknd 5666 8 5 5 CD cord-010119-t1x9gknd 5666 9 cases case NNS cord-010119-t1x9gknd 5666 10 of of IN cord-010119-t1x9gknd 5666 11 GTx GTx NNS cord-010119-t1x9gknd 5666 12 in in IN cord-010119-t1x9gknd 5666 13 pediatric pediatric JJ cord-010119-t1x9gknd 5666 14 patients patient NNS cord-010119-t1x9gknd 5666 15 with with IN cord-010119-t1x9gknd 5666 16 age age NN cord-010119-t1x9gknd 5666 17 from from IN cord-010119-t1x9gknd 5666 18 8 8 CD cord-010119-t1x9gknd 5666 19 months month NNS cord-010119-t1x9gknd 5666 20 to to IN cord-010119-t1x9gknd 5666 21 16 16 CD cord-010119-t1x9gknd 5666 22 years year NNS cord-010119-t1x9gknd 5666 23 old old JJ cord-010119-t1x9gknd 5666 24 , , , cord-010119-t1x9gknd 5666 25 neutropenic neutropenic JJ cord-010119-t1x9gknd 5666 26 , , , cord-010119-t1x9gknd 5666 27 with with IN cord-010119-t1x9gknd 5666 28 severe severe JJ cord-010119-t1x9gknd 5666 29 infection infection NN cord-010119-t1x9gknd 5666 30 resistant resistant JJ cord-010119-t1x9gknd 5666 31 to to IN cord-010119-t1x9gknd 5666 32 antibiotics antibiotic NNS cord-010119-t1x9gknd 5666 33 and/or and/or CC cord-010119-t1x9gknd 5666 34 antifungal antifungal JJ cord-010119-t1x9gknd 5666 35 therapy therapy NN cord-010119-t1x9gknd 5666 36 , , , cord-010119-t1x9gknd 5666 37 undergoing undergo VBG cord-010119-t1x9gknd 5666 38 HSCT HSCT NNP cord-010119-t1x9gknd 5666 39 and and CC cord-010119-t1x9gknd 5666 40 chemotherapy chemotherapy NN cord-010119-t1x9gknd 5666 41 . . . cord-010119-t1x9gknd 5667 1 Study Study NNP cord-010119-t1x9gknd 5667 2 Design Design NNP cord-010119-t1x9gknd 5667 3 / / SYM cord-010119-t1x9gknd 5667 4 Method method NN cord-010119-t1x9gknd 5667 5 : : : cord-010119-t1x9gknd 5667 6 Donors donor NNS cord-010119-t1x9gknd 5667 7 : : : cord-010119-t1x9gknd 5667 8 Data datum NNS cord-010119-t1x9gknd 5667 9 concerning concern VBG cord-010119-t1x9gknd 5667 10 a a DT cord-010119-t1x9gknd 5667 11 total total NN cord-010119-t1x9gknd 5667 12 of of IN cord-010119-t1x9gknd 5667 13 56 56 CD cord-010119-t1x9gknd 5667 14 granulocytes granulocyte NNS cord-010119-t1x9gknd 5667 15 donations donation NNS cord-010119-t1x9gknd 5667 16 from from IN cord-010119-t1x9gknd 5667 17 2015 2015 CD cord-010119-t1x9gknd 5667 18 to to IN cord-010119-t1x9gknd 5667 19 2016 2016 CD cord-010119-t1x9gknd 5667 20 were be VBD cord-010119-t1x9gknd 5667 21 collected collect VBN cord-010119-t1x9gknd 5667 22 from from IN cord-010119-t1x9gknd 5667 23 43 43 CD cord-010119-t1x9gknd 5667 24 health health NN cord-010119-t1x9gknd 5667 25 donors donor NNS cord-010119-t1x9gknd 5667 26 ( ( -LRB- cord-010119-t1x9gknd 5667 27 21 21 CD cord-010119-t1x9gknd 5667 28 male/ male/ SYM cord-010119-t1x9gknd 5667 29 22 22 CD cord-010119-t1x9gknd 5667 30 female female NN cord-010119-t1x9gknd 5667 31 ) ) -RRB- cord-010119-t1x9gknd 5667 32 . . . cord-010119-t1x9gknd 5668 1 Donors donor NNS cord-010119-t1x9gknd 5668 2 had have VBD cord-010119-t1x9gknd 5668 3 matched match VBN cord-010119-t1x9gknd 5668 4 blood blood NN cord-010119-t1x9gknd 5668 5 type type NN cord-010119-t1x9gknd 5668 6 and and CC cord-010119-t1x9gknd 5668 7 serology serology NN cord-010119-t1x9gknd 5668 8 status status NN cord-010119-t1x9gknd 5668 9 for for IN cord-010119-t1x9gknd 5668 10 cytomegalovirus cytomegalovirus NN cord-010119-t1x9gknd 5668 11 when when WRB cord-010119-t1x9gknd 5668 12 the the DT cord-010119-t1x9gknd 5668 13 patient patient NN cord-010119-t1x9gknd 5668 14 was be VBD cord-010119-t1x9gknd 5668 15 negative negative JJ cord-010119-t1x9gknd 5668 16 . . . cord-010119-t1x9gknd 5669 1 Granulocytes granulocyte NNS cord-010119-t1x9gknd 5669 2 were be VBD cord-010119-t1x9gknd 5669 3 mobilized mobilize VBN cord-010119-t1x9gknd 5669 4 with with IN cord-010119-t1x9gknd 5669 5 a a DT cord-010119-t1x9gknd 5669 6 single single JJ cord-010119-t1x9gknd 5669 7 dose dose NN cord-010119-t1x9gknd 5669 8 of of IN cord-010119-t1x9gknd 5669 9 rHu rhu NN cord-010119-t1x9gknd 5669 10 - - HYPH cord-010119-t1x9gknd 5669 11 G G NNP cord-010119-t1x9gknd 5669 12 - - HYPH cord-010119-t1x9gknd 5669 13 CSF CSF NNP cord-010119-t1x9gknd 5669 14 ( ( -LRB- cord-010119-t1x9gknd 5669 15 Filgrastim Filgrastim NNP cord-010119-t1x9gknd 5669 16 ) ) -RRB- cord-010119-t1x9gknd 5669 17 subcutaneously subcutaneously RB cord-010119-t1x9gknd 5669 18 , , , cord-010119-t1x9gknd 5669 19 5mcg 5mcg CD cord-010119-t1x9gknd 5669 20 / / SYM cord-010119-t1x9gknd 5669 21 kg kg NN cord-010119-t1x9gknd 5669 22 / / SYM cord-010119-t1x9gknd 5669 23 dose dose NN cord-010119-t1x9gknd 5669 24 ( ( -LRB- cord-010119-t1x9gknd 5669 25 donors donor NNS cord-010119-t1x9gknd 5669 26 up up IN cord-010119-t1x9gknd 5669 27 to to TO cord-010119-t1x9gknd 5669 28 70 70 CD cord-010119-t1x9gknd 5669 29 kg kg NNS cord-010119-t1x9gknd 5669 30 , , , cord-010119-t1x9gknd 5669 31 maximum maximum NN cord-010119-t1x9gknd 5669 32 of of IN cord-010119-t1x9gknd 5669 33 600mcg 600mcg CD cord-010119-t1x9gknd 5669 34 ) ) -RRB- cord-010119-t1x9gknd 5669 35 and and CC cord-010119-t1x9gknd 5669 36 oral oral JJ cord-010119-t1x9gknd 5669 37 dexamethasone dexamethasone NN cord-010119-t1x9gknd 5669 38 ( ( -LRB- cord-010119-t1x9gknd 5669 39 8 8 CD cord-010119-t1x9gknd 5669 40 mg mg NNP cord-010119-t1x9gknd 5669 41 ) ) -RRB- cord-010119-t1x9gknd 5669 42 , , , cord-010119-t1x9gknd 5669 43 12h 12h , cord-010119-t1x9gknd 5669 44 prior prior RB cord-010119-t1x9gknd 5669 45 to to IN cord-010119-t1x9gknd 5669 46 apheresis apheresis NN cord-010119-t1x9gknd 5669 47 . . . cord-010119-t1x9gknd 5670 1 Apheresis Apheresis NNP cord-010119-t1x9gknd 5670 2 was be VBD cord-010119-t1x9gknd 5670 3 performed perform VBN cord-010119-t1x9gknd 5670 4 using use VBG cord-010119-t1x9gknd 5670 5 Cobe Cobe NNP cord-010119-t1x9gknd 5670 6 Spectra Spectra NNP cord-010119-t1x9gknd 5670 7 V V NNP cord-010119-t1x9gknd 5670 8 R R NNP cord-010119-t1x9gknd 5670 9 or or CC cord-010119-t1x9gknd 5670 10 Spectra Spectra NNP cord-010119-t1x9gknd 5670 11 Optia Optia NNP cord-010119-t1x9gknd 5670 12 V V NNP cord-010119-t1x9gknd 5670 13 R r NN cord-010119-t1x9gknd 5670 14 with with IN cord-010119-t1x9gknd 5670 15 citrate citrate NN cord-010119-t1x9gknd 5670 16 as as IN cord-010119-t1x9gknd 5670 17 anticoagulant anticoagulant NN cord-010119-t1x9gknd 5670 18 . . . cord-010119-t1x9gknd 5671 1 All all DT cord-010119-t1x9gknd 5671 2 products product NNS cord-010119-t1x9gknd 5671 3 were be VBD cord-010119-t1x9gknd 5671 4 irradiated irradiate VBN cord-010119-t1x9gknd 5671 5 with with IN cord-010119-t1x9gknd 5671 6 40Gy 40gy CD cord-010119-t1x9gknd 5671 7 . . . cord-010119-t1x9gknd 5672 1 Results result NNS cord-010119-t1x9gknd 5672 2 / / SYM cord-010119-t1x9gknd 5672 3 Finding Finding NNP cord-010119-t1x9gknd 5672 4 s s POS cord-010119-t1x9gknd 5672 5 : : : cord-010119-t1x9gknd 5673 1 Granulocytes granulocyte NNS cord-010119-t1x9gknd 5673 2 number number NN cord-010119-t1x9gknd 5673 3 increased increase VBD cord-010119-t1x9gknd 5673 4 5 5 CD cord-010119-t1x9gknd 5673 5 times time NNS cord-010119-t1x9gknd 5673 6 from from IN cord-010119-t1x9gknd 5673 7 basal basal NN cord-010119-t1x9gknd 5673 8 levels level NNS cord-010119-t1x9gknd 5673 9 and and CC cord-010119-t1x9gknd 5673 10 the the DT cord-010119-t1x9gknd 5673 11 median median NN cord-010119-t1x9gknd 5673 12 of of IN cord-010119-t1x9gknd 5673 13 cells cell NNS cord-010119-t1x9gknd 5673 14 collected collect VBN cord-010119-t1x9gknd 5673 15 were be VBD cord-010119-t1x9gknd 5673 16 4.89 4.89 CD cord-010119-t1x9gknd 5673 17 x10 x10 CD cord-010119-t1x9gknd 5673 18 10 10 CD cord-010119-t1x9gknd 5674 1 ( ( -LRB- cord-010119-t1x9gknd 5674 2 range range NN cord-010119-t1x9gknd 5674 3 1.09 1.09 CD cord-010119-t1x9gknd 5674 4 - - HYPH cord-010119-t1x9gknd 5674 5 9.85 9.85 CD cord-010119-t1x9gknd 5674 6 ) ) -RRB- cord-010119-t1x9gknd 5674 7 . . . cord-010119-t1x9gknd 5675 1 In in IN cord-010119-t1x9gknd 5675 2 general general JJ cord-010119-t1x9gknd 5675 3 donors donor NNS cord-010119-t1x9gknd 5675 4 reported report VBD cord-010119-t1x9gknd 5675 5 no no DT cord-010119-t1x9gknd 5675 6 significant significant JJ cord-010119-t1x9gknd 5675 7 adverse adverse JJ cord-010119-t1x9gknd 5675 8 reactions reaction NNS cord-010119-t1x9gknd 5675 9 . . . cord-010119-t1x9gknd 5676 1 From from IN cord-010119-t1x9gknd 5676 2 56 56 CD cord-010119-t1x9gknd 5676 3 donations donation NNS cord-010119-t1x9gknd 5676 4 , , , cord-010119-t1x9gknd 5676 5 only only RB cord-010119-t1x9gknd 5676 6 in in IN cord-010119-t1x9gknd 5676 7 4 4 CD cord-010119-t1x9gknd 5676 8 was be VBD cord-010119-t1x9gknd 5676 9 reported report VBN cord-010119-t1x9gknd 5676 10 light light JJ cord-010119-t1x9gknd 5676 11 paresthesia paresthesia NNS cord-010119-t1x9gknd 5676 12 during during IN cord-010119-t1x9gknd 5676 13 the the DT cord-010119-t1x9gknd 5676 14 procedure procedure NN cord-010119-t1x9gknd 5676 15 . . . cord-010119-t1x9gknd 5677 1 Patients patient NNS cord-010119-t1x9gknd 5677 2 : : : cord-010119-t1x9gknd 5678 1 All all DT cord-010119-t1x9gknd 5678 2 patients patient NNS cord-010119-t1x9gknd 5678 3 were be VBD cord-010119-t1x9gknd 5678 4 medicated medicate VBN cord-010119-t1x9gknd 5678 5 prior prior RB cord-010119-t1x9gknd 5678 6 to to IN cord-010119-t1x9gknd 5678 7 transfusions transfusion NNS cord-010119-t1x9gknd 5678 8 with with IN cord-010119-t1x9gknd 5678 9 diphenhydramine diphenhydramine NN cord-010119-t1x9gknd 5678 10 and and CC cord-010119-t1x9gknd 5678 11 acetaminophen acetaminophen NN cord-010119-t1x9gknd 5678 12 . . . cord-010119-t1x9gknd 5679 1 The the DT cord-010119-t1x9gknd 5679 2 product product NN cord-010119-t1x9gknd 5679 3 was be VBD cord-010119-t1x9gknd 5679 4 transfused transfuse VBN cord-010119-t1x9gknd 5679 5 within within IN cord-010119-t1x9gknd 5679 6 24 24 CD cord-010119-t1x9gknd 5679 7 hours hour NNS cord-010119-t1x9gknd 5679 8 after after IN cord-010119-t1x9gknd 5679 9 collection collection NN cord-010119-t1x9gknd 5679 10 , , , cord-010119-t1x9gknd 5679 11 with with IN cord-010119-t1x9gknd 5679 12 efforts effort NNS cord-010119-t1x9gknd 5679 13 to to TO cord-010119-t1x9gknd 5679 14 transfuse transfuse VB cord-010119-t1x9gknd 5679 15 as as RB cord-010119-t1x9gknd 5679 16 soon soon RB cord-010119-t1x9gknd 5679 17 as as IN cord-010119-t1x9gknd 5679 18 possible possible JJ cord-010119-t1x9gknd 5679 19 . . . cord-010119-t1x9gknd 5680 1 Details detail NNS cord-010119-t1x9gknd 5680 2 about about IN cord-010119-t1x9gknd 5680 3 the the DT cord-010119-t1x9gknd 5680 4 transfusions transfusion NNS cord-010119-t1x9gknd 5680 5 are be VBP cord-010119-t1x9gknd 5680 6 described describe VBN cord-010119-t1x9gknd 5680 7 on on IN cord-010119-t1x9gknd 5680 8 Table Table NNP cord-010119-t1x9gknd 5680 9 1 1 CD cord-010119-t1x9gknd 5680 10 . . . cord-010119-t1x9gknd 5681 1 Adverse adverse JJ cord-010119-t1x9gknd 5681 2 reactions reaction NNS cord-010119-t1x9gknd 5681 3 for for IN cord-010119-t1x9gknd 5681 4 patients patient NNS cord-010119-t1x9gknd 5681 5 were be VBD cord-010119-t1x9gknd 5681 6 minor minor JJ cord-010119-t1x9gknd 5681 7 and and CC cord-010119-t1x9gknd 5681 8 not not RB cord-010119-t1x9gknd 5681 9 frequent frequent JJ cord-010119-t1x9gknd 5681 10 ( ( -LRB- cord-010119-t1x9gknd 5681 11 4 4 CD cord-010119-t1x9gknd 5681 12 in in IN cord-010119-t1x9gknd 5681 13 66 66 CD cord-010119-t1x9gknd 5681 14 GTx GTx NNS cord-010119-t1x9gknd 5681 15 ) ) -RRB- cord-010119-t1x9gknd 5681 16 including include VBG cord-010119-t1x9gknd 5681 17 vomiting vomit VBG cord-010119-t1x9gknd 5681 18 , , , cord-010119-t1x9gknd 5681 19 hypotension hypotension NN cord-010119-t1x9gknd 5681 20 and and CC cord-010119-t1x9gknd 5681 21 headache headache NN cord-010119-t1x9gknd 5681 22 , , , cord-010119-t1x9gknd 5681 23 which which WDT cord-010119-t1x9gknd 5681 24 resolved resolve VBD cord-010119-t1x9gknd 5681 25 without without IN cord-010119-t1x9gknd 5681 26 serious serious JJ cord-010119-t1x9gknd 5681 27 or or CC cord-010119-t1x9gknd 5681 28 lasting lasting JJ cord-010119-t1x9gknd 5681 29 complications complication NNS cord-010119-t1x9gknd 5681 30 , , , cord-010119-t1x9gknd 5681 31 assuming assume VBG cord-010119-t1x9gknd 5681 32 that that IN cord-010119-t1x9gknd 5681 33 GTx gtx NN cord-010119-t1x9gknd 5681 34 is be VBZ cord-010119-t1x9gknd 5681 35 well well RB cord-010119-t1x9gknd 5681 36 tolerated tolerate VBN cord-010119-t1x9gknd 5681 37 . . . cord-010119-t1x9gknd 5682 1 Conclusion conclusion NN cord-010119-t1x9gknd 5682 2 : : : cord-010119-t1x9gknd 5683 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5683 2 study study NN cord-010119-t1x9gknd 5683 3 provides provide VBZ cord-010119-t1x9gknd 5683 4 further further JJ cord-010119-t1x9gknd 5683 5 evidence evidence NN cord-010119-t1x9gknd 5683 6 that that IN cord-010119-t1x9gknd 5683 7 GTx GTx NNS cord-010119-t1x9gknd 5683 8 transfusions transfusion NNS cord-010119-t1x9gknd 5683 9 can can MD cord-010119-t1x9gknd 5683 10 be be VB cord-010119-t1x9gknd 5683 11 safely safely RB cord-010119-t1x9gknd 5683 12 performed perform VBN cord-010119-t1x9gknd 5683 13 on on IN cord-010119-t1x9gknd 5683 14 pediatric pediatric JJ cord-010119-t1x9gknd 5683 15 patients patient NNS cord-010119-t1x9gknd 5683 16 . . . cord-010119-t1x9gknd 5684 1 Irina Irina NNP cord-010119-t1x9gknd 5684 2 Kumukova Kumukova NNP cord-010119-t1x9gknd 5684 3 * * NFP cord-010119-t1x9gknd 5684 4 1 1 CD cord-010119-t1x9gknd 5684 5 , , , cord-010119-t1x9gknd 5684 6 Elena Elena NNP cord-010119-t1x9gknd 5684 7 Kurnikova Kurnikova NNP cord-010119-t1x9gknd 5684 8 1 1 CD cord-010119-t1x9gknd 5684 9 and and CC cord-010119-t1x9gknd 5684 10 Pavel Pavel NNP cord-010119-t1x9gknd 5684 11 Trakhtman Trakhtman NNP cord-010119-t1x9gknd 5684 12 2 2 CD cord-010119-t1x9gknd 5684 13 . . . cord-010119-t1x9gknd 5684 14 1 1 CD cord-010119-t1x9gknd 5684 15 Russian Russian NNP cord-010119-t1x9gknd 5684 16 Institute Institute NNP cord-010119-t1x9gknd 5684 17 for for IN cord-010119-t1x9gknd 5684 18 paediatric paediatric NNP cord-010119-t1x9gknd 5684 19 haematology haematology NNP cord-010119-t1x9gknd 5684 20 , , , cord-010119-t1x9gknd 5684 21 oncology oncology NN cord-010119-t1x9gknd 5684 22 and and CC cord-010119-t1x9gknd 5684 23 immunology immunology NN cord-010119-t1x9gknd 5684 24 , , , cord-010119-t1x9gknd 5685 1 2 2 LS cord-010119-t1x9gknd 5685 2 InstitutefFor InstitutefFor NNP cord-010119-t1x9gknd 5685 3 Pediatric Pediatric NNP cord-010119-t1x9gknd 5685 4 Hematology Hematology NNP cord-010119-t1x9gknd 5685 5 , , , cord-010119-t1x9gknd 5685 6 oncology oncology NN cord-010119-t1x9gknd 5685 7 and and CC cord-010119-t1x9gknd 5685 8 immunology immunology NN cord-010119-t1x9gknd 5685 9 Background Background NNP cord-010119-t1x9gknd 5685 10 / / SYM cord-010119-t1x9gknd 5685 11 Case Case NNP cord-010119-t1x9gknd 5685 12 Studies Studies NNPS cord-010119-t1x9gknd 5685 13 : : : cord-010119-t1x9gknd 5686 1 Infections infection NNS cord-010119-t1x9gknd 5686 2 cause cause VBP cord-010119-t1x9gknd 5686 3 major major JJ cord-010119-t1x9gknd 5686 4 mortality mortality NN cord-010119-t1x9gknd 5686 5 among among IN cord-010119-t1x9gknd 5686 6 persons person NNS cord-010119-t1x9gknd 5686 7 with with IN cord-010119-t1x9gknd 5686 8 prolonged prolonged JJ cord-010119-t1x9gknd 5686 9 neutropenia neutropenia NN cord-010119-t1x9gknd 5686 10 related relate VBN cord-010119-t1x9gknd 5686 11 to to IN cord-010119-t1x9gknd 5686 12 HSCT HSCT NNP cord-010119-t1x9gknd 5686 13 and and CC cord-010119-t1x9gknd 5686 14 chemotherapy chemotherapy NN cord-010119-t1x9gknd 5686 15 and and CC cord-010119-t1x9gknd 5686 16 among among IN cord-010119-t1x9gknd 5686 17 patients patient NNS cord-010119-t1x9gknd 5686 18 with with IN cord-010119-t1x9gknd 5686 19 granulocyte granulocyte NN cord-010119-t1x9gknd 5686 20 disorder disorder NN cord-010119-t1x9gknd 5686 21 . . . cord-010119-t1x9gknd 5687 1 The the DT cord-010119-t1x9gknd 5687 2 granulocyte granulocyte NN cord-010119-t1x9gknd 5687 3 transfusion transfusion NN cord-010119-t1x9gknd 5687 4 therapy therapy NN cord-010119-t1x9gknd 5687 5 , , , cord-010119-t1x9gknd 5687 6 a a DT cord-010119-t1x9gknd 5687 7 logical logical JJ cord-010119-t1x9gknd 5687 8 approach approach NN cord-010119-t1x9gknd 5687 9 in in IN cord-010119-t1x9gknd 5687 10 treating treat VBG cord-010119-t1x9gknd 5687 11 patients patient NNS cord-010119-t1x9gknd 5687 12 with with IN cord-010119-t1x9gknd 5687 13 infections infection NNS cord-010119-t1x9gknd 5687 14 , , , cord-010119-t1x9gknd 5687 15 who who WP cord-010119-t1x9gknd 5687 16 are be VBP cord-010119-t1x9gknd 5687 17 refractory refractory JJ cord-010119-t1x9gknd 5687 18 to to IN cord-010119-t1x9gknd 5687 19 antibiotics antibiotic NNS cord-010119-t1x9gknd 5687 20 . . . cord-010119-t1x9gknd 5688 1 We -PRON- PRP cord-010119-t1x9gknd 5688 2 want want VBP cord-010119-t1x9gknd 5688 3 to to TO cord-010119-t1x9gknd 5688 4 demonstrate demonstrate VB cord-010119-t1x9gknd 5688 5 our -PRON- PRP$ cord-010119-t1x9gknd 5688 6 granulocyte granulocyte NN cord-010119-t1x9gknd 5688 7 transfusions transfusion NNS cord-010119-t1x9gknd 5688 8 experience experience VBP cord-010119-t1x9gknd 5688 9 in in IN cord-010119-t1x9gknd 5688 10 children child NNS cord-010119-t1x9gknd 5688 11 who who WP cord-010119-t1x9gknd 5688 12 have have VBP cord-010119-t1x9gknd 5688 13 neutropenia neutropenia NN cord-010119-t1x9gknd 5688 14 or or CC cord-010119-t1x9gknd 5688 15 defects defect NNS cord-010119-t1x9gknd 5688 16 of of IN cord-010119-t1x9gknd 5688 17 the the DT cord-010119-t1x9gknd 5688 18 immune immune JJ cord-010119-t1x9gknd 5688 19 system system NN cord-010119-t1x9gknd 5688 20 , , , cord-010119-t1x9gknd 5688 21 with with IN cord-010119-t1x9gknd 5688 22 severe severe JJ cord-010119-t1x9gknd 5688 23 infections infection NNS cord-010119-t1x9gknd 5689 1 Study Study NNP cord-010119-t1x9gknd 5689 2 Design Design NNP cord-010119-t1x9gknd 5689 3 / / SYM cord-010119-t1x9gknd 5689 4 Method method NN cord-010119-t1x9gknd 5689 5 : : : cord-010119-t1x9gknd 5689 6 We -PRON- PRP cord-010119-t1x9gknd 5689 7 analyzed analyze VBD cord-010119-t1x9gknd 5689 8 the the DT cord-010119-t1x9gknd 5689 9 retrospective retrospective JJ cord-010119-t1x9gknd 5689 10 data datum NNS cord-010119-t1x9gknd 5689 11 for for IN cord-010119-t1x9gknd 5689 12 the the DT cord-010119-t1x9gknd 5689 13 period period NN cord-010119-t1x9gknd 5689 14 04/2012 04/2012 CD cord-010119-t1x9gknd 5689 15 - - HYPH cord-010119-t1x9gknd 5689 16 02/2016 02/2016 CD cord-010119-t1x9gknd 5689 17 . . . cord-010119-t1x9gknd 5690 1 Donors donor NNS cord-010119-t1x9gknd 5690 2 underwent undergo VBD cord-010119-t1x9gknd 5690 3 granulocyte granulocyte NN cord-010119-t1x9gknd 5690 4 mobilization mobilization NN cord-010119-t1x9gknd 5690 5 with with IN cord-010119-t1x9gknd 5690 6 G G NNP cord-010119-t1x9gknd 5690 7 - - HYPH cord-010119-t1x9gknd 5690 8 CSF CSF NNP cord-010119-t1x9gknd 5690 9 in in IN cord-010119-t1x9gknd 5690 10 a a DT cord-010119-t1x9gknd 5690 11 dose dose JJ cord-010119-t1x9gknd 5690 12 3 3 CD cord-010119-t1x9gknd 5690 13 - - SYM cord-010119-t1x9gknd 5690 14 5 5 CD cord-010119-t1x9gknd 5690 15 mg mg NNP cord-010119-t1x9gknd 5690 16 / / SYM cord-010119-t1x9gknd 5690 17 kg kg NNP cord-010119-t1x9gknd 5690 18 s.c s.c NNP cord-010119-t1x9gknd 5690 19 . . NNP cord-010119-t1x9gknd 5690 20 12 12 CD cord-010119-t1x9gknd 5690 21 - - SYM cord-010119-t1x9gknd 5690 22 16 16 CD cord-010119-t1x9gknd 5690 23 hrs hrs NN cord-010119-t1x9gknd 5690 24 prior prior RB cord-010119-t1x9gknd 5690 25 to to IN cord-010119-t1x9gknd 5690 26 donation donation NN cord-010119-t1x9gknd 5690 27 ; ; : cord-010119-t1x9gknd 5690 28 granulocytes granulocyte NNS cord-010119-t1x9gknd 5690 29 were be VBD cord-010119-t1x9gknd 5690 30 collected collect VBN cord-010119-t1x9gknd 5690 31 with with IN cord-010119-t1x9gknd 5690 32 COBE COBE NNP cord-010119-t1x9gknd 5690 33 Spectra Spectra NNP cord-010119-t1x9gknd 5690 34 , , , cord-010119-t1x9gknd 5690 35 CaridianBCT CaridianBCT NNP cord-010119-t1x9gknd 5690 36 . . . cord-010119-t1x9gknd 5691 1 The the DT cord-010119-t1x9gknd 5691 2 analysis analysis NN cord-010119-t1x9gknd 5691 3 was be VBD cord-010119-t1x9gknd 5691 4 performed perform VBN cord-010119-t1x9gknd 5691 5 through through IN cord-010119-t1x9gknd 5691 6 Microsoft Microsoft NNP cord-010119-t1x9gknd 5691 7 Excel Excel NNP cord-010119-t1x9gknd 5691 8 , , , cord-010119-t1x9gknd 5691 9 nonparametric nonparametric JJ cord-010119-t1x9gknd 5691 10 Mann Mann NNP cord-010119-t1x9gknd 5691 11 - - HYPH cord-010119-t1x9gknd 5691 12 Whitney Whitney NNP cord-010119-t1x9gknd 5691 13 's 's POS cord-010119-t1x9gknd 5691 14 and and CC cord-010119-t1x9gknd 5691 15 Spearman Spearman NNP cord-010119-t1x9gknd 5691 16 tests test NNS cord-010119-t1x9gknd 5691 17 Results/ Results/ . cord-010119-t1x9gknd 5692 1 Finding finding NN cord-010119-t1x9gknd 5692 2 : : : cord-010119-t1x9gknd 5693 1 Was be VBD cord-010119-t1x9gknd 5693 2 performed perform VBN cord-010119-t1x9gknd 5693 3 169 169 CD cord-010119-t1x9gknd 5693 4 granulocytes granulocyte NNS cord-010119-t1x9gknd 5693 5 collections collection NNS cord-010119-t1x9gknd 5693 6 in in IN cord-010119-t1x9gknd 5693 7 153 153 CD cord-010119-t1x9gknd 5693 8 donors donor NNS cord-010119-t1x9gknd 5693 9 ( ( -LRB- cord-010119-t1x9gknd 5693 10 82 82 CD cord-010119-t1x9gknd 5693 11 f f NNP cord-010119-t1x9gknd 5693 12 , , , cord-010119-t1x9gknd 5693 13 71 71 CD cord-010119-t1x9gknd 5693 14 m m NNP cord-010119-t1x9gknd 5693 15 ) ) -RRB- cord-010119-t1x9gknd 5693 16 , , , cord-010119-t1x9gknd 5693 17 ages age NNS cord-010119-t1x9gknd 5693 18 18 18 CD cord-010119-t1x9gknd 5693 19 to to IN cord-010119-t1x9gknd 5693 20 58 58 CD cord-010119-t1x9gknd 5693 21 . . . cord-010119-t1x9gknd 5694 1 The the DT cord-010119-t1x9gknd 5694 2 mean mean JJ cord-010119-t1x9gknd 5694 3 increment increment NN cord-010119-t1x9gknd 5694 4 of of IN cord-010119-t1x9gknd 5694 5 WBC WBC NNP cord-010119-t1x9gknd 5694 6 after after IN cord-010119-t1x9gknd 5694 7 stimulation stimulation NN cord-010119-t1x9gknd 5694 8 was be VBD cord-010119-t1x9gknd 5694 9 22,6x10 22,6x10 CD cord-010119-t1x9gknd 5695 1 9 9 LS cord-010119-t1x9gknd 5695 2 / / SYM cord-010119-t1x9gknd 5695 3 L l NN cord-010119-t1x9gknd 5695 4 ( ( -LRB- cord-010119-t1x9gknd 5695 5 9,2 9,2 CD cord-010119-t1x9gknd 5695 6 - - SYM cord-010119-t1x9gknd 5695 7 41,9 41,9 CD cord-010119-t1x9gknd 5695 8 x10 x10 CD cord-010119-t1x9gknd 5695 9 9 9 CD cord-010119-t1x9gknd 5695 10 / / SYM cord-010119-t1x9gknd 5695 11 L l NN cord-010119-t1x9gknd 5695 12 ; ; : cord-010119-t1x9gknd 5695 13 f-23,2 f-23,2 NNP cord-010119-t1x9gknd 5695 14 x10 x10 CD cord-010119-t1x9gknd 5695 15 9 9 CD cord-010119-t1x9gknd 5695 16 / / SYM cord-010119-t1x9gknd 5695 17 L l NN cord-010119-t1x9gknd 5695 18 ; ; : cord-010119-t1x9gknd 5695 19 m-21.9 m-21.9 NNP cord-010119-t1x9gknd 5695 20 x10 x10 CD cord-010119-t1x9gknd 5695 21 9 9 CD cord-010119-t1x9gknd 5695 22 / / SYM cord-010119-t1x9gknd 5695 23 L L NNP cord-010119-t1x9gknd 5695 24 ) ) -RRB- cord-010119-t1x9gknd 5695 25 ; ; : cord-010119-t1x9gknd 5695 26 in in IN cord-010119-t1x9gknd 5695 27 the the DT cord-010119-t1x9gknd 5695 28 age age NN cord-010119-t1x9gknd 5695 29 groups group NNS cord-010119-t1x9gknd 5695 30 18 18 CD cord-010119-t1x9gknd 5695 31 - - SYM cord-010119-t1x9gknd 5695 32 39 39 CD cord-010119-t1x9gknd 5695 33 years year NNS cord-010119-t1x9gknd 5695 34 ( ( -LRB- cord-010119-t1x9gknd 5695 35 n5121 n5121 NNP cord-010119-t1x9gknd 5695 36 ) ) -RRB- cord-010119-t1x9gknd 5695 37 and and CC cord-010119-t1x9gknd 5695 38 over over IN cord-010119-t1x9gknd 5695 39 40 40 CD cord-010119-t1x9gknd 5695 40 years year NNS cord-010119-t1x9gknd 5695 41 ( ( -LRB- cord-010119-t1x9gknd 5695 42 n532 n532 NNP cord-010119-t1x9gknd 5695 43 ) ) -RRB- cord-010119-t1x9gknd 5695 44 , , , cord-010119-t1x9gknd 5695 45 the the DT cord-010119-t1x9gknd 5695 46 mean mean JJ cord-010119-t1x9gknd 5695 47 increment increment NN cord-010119-t1x9gknd 5695 48 of of IN cord-010119-t1x9gknd 5695 49 WBC WBC NNP cord-010119-t1x9gknd 5695 50 was be VBD cord-010119-t1x9gknd 5695 51 respectively respectively RB cord-010119-t1x9gknd 5695 52 22,2 22,2 CD cord-010119-t1x9gknd 5695 53 x10 x10 NN cord-010119-t1x9gknd 5695 54 9 9 CD cord-010119-t1x9gknd 5695 55 / / SYM cord-010119-t1x9gknd 5695 56 L l NN cord-010119-t1x9gknd 5695 57 ( ( -LRB- cord-010119-t1x9gknd 5695 58 9,2 9,2 CD cord-010119-t1x9gknd 5695 59 - - SYM cord-010119-t1x9gknd 5695 60 41,9x10 41,9x10 CD cord-010119-t1x9gknd 5695 61 9 9 CD cord-010119-t1x9gknd 5695 62 / / SYM cord-010119-t1x9gknd 5695 63 L L NNP cord-010119-t1x9gknd 5695 64 ) ) -RRB- cord-010119-t1x9gknd 5695 65 and and CC cord-010119-t1x9gknd 5695 66 24,02x10 24,02x10 CD cord-010119-t1x9gknd 5695 67 9 9 CD cord-010119-t1x9gknd 5695 68 / / SYM cord-010119-t1x9gknd 5695 69 L l NN cord-010119-t1x9gknd 5695 70 ( ( -LRB- cord-010119-t1x9gknd 5695 71 12,6 12,6 CD cord-010119-t1x9gknd 5695 72 - - SYM cord-010119-t1x9gknd 5695 73 35 35 CD cord-010119-t1x9gknd 5695 74 x10 x10 CD cord-010119-t1x9gknd 5695 75 9 9 CD cord-010119-t1x9gknd 5695 76 / / SYM cord-010119-t1x9gknd 5695 77 L L NNP cord-010119-t1x9gknd 5695 78 ) ) -RRB- cord-010119-t1x9gknd 5695 79 . . . cord-010119-t1x9gknd 5696 1 The the DT cord-010119-t1x9gknd 5696 2 mean mean JJ cord-010119-t1x9gknd 5696 3 volume volume NN cord-010119-t1x9gknd 5696 4 of of IN cord-010119-t1x9gknd 5696 5 treated treat VBN cord-010119-t1x9gknd 5696 6 blood blood NN cord-010119-t1x9gknd 5696 7 was be VBD cord-010119-t1x9gknd 5696 8 566 566 CD cord-010119-t1x9gknd 5696 9 , , , cord-010119-t1x9gknd 5696 10 a50,05 a50,05 NNP cord-010119-t1x9gknd 5696 11 ) ) -RRB- cord-010119-t1x9gknd 5696 12 . . . cord-010119-t1x9gknd 5697 1 The the DT cord-010119-t1x9gknd 5697 2 mean mean JJ cord-010119-t1x9gknd 5697 3 number number NN cord-010119-t1x9gknd 5697 4 of of IN cord-010119-t1x9gknd 5697 5 total total JJ cord-010119-t1x9gknd 5697 6 WBC WBC NNP cord-010119-t1x9gknd 5697 7 in in IN cord-010119-t1x9gknd 5697 8 the the DT cord-010119-t1x9gknd 5697 9 product product NN cord-010119-t1x9gknd 5697 10 was be VBD cord-010119-t1x9gknd 5697 11 38,43x10 38,43x10 CD cord-010119-t1x9gknd 5697 12 9 9 CD cord-010119-t1x9gknd 5697 13 / / SYM cord-010119-t1x9gknd 5697 14 L L NNP cord-010119-t1x9gknd 5697 15 ( ( -LRB- cord-010119-t1x9gknd 5697 16 13.38 13.38 CD cord-010119-t1x9gknd 5697 17 - - SYM cord-010119-t1x9gknd 5697 18 77x10 77x10 CD cord-010119-t1x9gknd 5697 19 9/ 9/ CD cord-010119-t1x9gknd 5697 20 L l NN cord-010119-t1x9gknd 5697 21 ; ; : cord-010119-t1x9gknd 5697 22 f-34,8x10 f-34,8x10 NNP cord-010119-t1x9gknd 5697 23 9 9 CD cord-010119-t1x9gknd 5697 24 / / SYM cord-010119-t1x9gknd 5697 25 L L NNP cord-010119-t1x9gknd 5697 26 , , , cord-010119-t1x9gknd 5697 27 m-42,7x10 m-42,7x10 NNP cord-010119-t1x9gknd 5697 28 9 9 CD cord-010119-t1x9gknd 5697 29 / / SYM cord-010119-t1x9gknd 5697 30 L L NNP cord-010119-t1x9gknd 5697 31 ) ) -RRB- cord-010119-t1x9gknd 5697 32 . . . cord-010119-t1x9gknd 5698 1 Only only RB cord-010119-t1x9gknd 5698 2 three three CD cord-010119-t1x9gknd 5698 3 donors donor NNS cord-010119-t1x9gknd 5698 4 ( ( -LRB- cord-010119-t1x9gknd 5698 5 1,96 1,96 CD cord-010119-t1x9gknd 5698 6 % % NN cord-010119-t1x9gknd 5698 7 ) ) -RRB- cord-010119-t1x9gknd 5698 8 had have VBD cord-010119-t1x9gknd 5698 9 apheresisrelated apheresisrelate VBN cord-010119-t1x9gknd 5698 10 adverse adverse JJ cord-010119-t1x9gknd 5698 11 effects effect NNS cord-010119-t1x9gknd 5699 1 The the DT cord-010119-t1x9gknd 5699 2 analysis analysis NN cord-010119-t1x9gknd 5699 3 included include VBD cord-010119-t1x9gknd 5699 4 244 244 CD cord-010119-t1x9gknd 5699 5 granulocyte granulocyte NN cord-010119-t1x9gknd 5699 6 transfusions transfusion NNS cord-010119-t1x9gknd 5699 7 in in IN cord-010119-t1x9gknd 5699 8 35 35 CD cord-010119-t1x9gknd 5699 9 cases case NNS cord-010119-t1x9gknd 5699 10 of of IN cord-010119-t1x9gknd 5699 11 infectious infectious JJ cord-010119-t1x9gknd 5699 12 complications complication NNS cord-010119-t1x9gknd 5699 13 in in IN cord-010119-t1x9gknd 5699 14 32 32 CD cord-010119-t1x9gknd 5699 15 patients patient NNS cord-010119-t1x9gknd 5699 16 . . . cord-010119-t1x9gknd 5700 1 The the DT cord-010119-t1x9gknd 5700 2 mean mean JJ cord-010119-t1x9gknd 5700 3 number number NN cord-010119-t1x9gknd 5700 4 of of IN cord-010119-t1x9gknd 5700 5 transfusions transfusion NNS cord-010119-t1x9gknd 5700 6 was be VBD cord-010119-t1x9gknd 5700 7 6.9 6.9 CD cord-010119-t1x9gknd 5700 8 ( ( -LRB- cord-010119-t1x9gknd 5700 9 1 1 CD cord-010119-t1x9gknd 5700 10 - - SYM cord-010119-t1x9gknd 5700 11 60 60 CD cord-010119-t1x9gknd 5700 12 ) ) -RRB- cord-010119-t1x9gknd 5700 13 . . . cord-010119-t1x9gknd 5701 1 Each each DT cord-010119-t1x9gknd 5701 2 patient patient NN cord-010119-t1x9gknd 5701 3 received receive VBD cord-010119-t1x9gknd 5701 4 transfusions transfusion NNS cord-010119-t1x9gknd 5701 5 from from IN cord-010119-t1x9gknd 5701 6 mean mean JJ cord-010119-t1x9gknd 5701 7 5 5 CD cord-010119-t1x9gknd 5701 8 donors donor NNS cord-010119-t1x9gknd 5701 9 ( ( -LRB- cord-010119-t1x9gknd 5701 10 1 1 CD cord-010119-t1x9gknd 5701 11 - - SYM cord-010119-t1x9gknd 5701 12 32 32 CD cord-010119-t1x9gknd 5701 13 ) ) -RRB- cord-010119-t1x9gknd 5701 14 ; ; : cord-010119-t1x9gknd 5701 15 the the DT cord-010119-t1x9gknd 5701 16 granulocyte granulocyte NN cord-010119-t1x9gknd 5701 17 transfusions transfusion NNS cord-010119-t1x9gknd 5701 18 started start VBD cord-010119-t1x9gknd 5701 19 at at IN cord-010119-t1x9gknd 5701 20 the the DT cord-010119-t1x9gknd 5701 21 mean mean JJ cord-010119-t1x9gknd 5701 22 8 8 CD cord-010119-t1x9gknd 5701 23 days day NNS cord-010119-t1x9gknd 5701 24 ( ( -LRB- cord-010119-t1x9gknd 5701 25 2 2 CD cord-010119-t1x9gknd 5701 26 - - SYM cord-010119-t1x9gknd 5701 27 30 30 CD cord-010119-t1x9gknd 5701 28 ) ) -RRB- cord-010119-t1x9gknd 5701 29 after after IN cord-010119-t1x9gknd 5701 30 infection infection NN cord-010119-t1x9gknd 5701 31 ; ; : cord-010119-t1x9gknd 5701 32 the the DT cord-010119-t1x9gknd 5701 33 mean mean JJ cord-010119-t1x9gknd 5701 34 dose dose NN cord-010119-t1x9gknd 5701 35 of of IN cord-010119-t1x9gknd 5701 36 WBC WBC NNP cord-010119-t1x9gknd 5701 37 on on IN cord-010119-t1x9gknd 5701 38 the the DT cord-010119-t1x9gknd 5701 39 transfusion transfusion NN cord-010119-t1x9gknd 5701 40 was be VBD cord-010119-t1x9gknd 5701 41 11.6x10 11.6x10 CD cord-010119-t1x9gknd 5701 42 8 8 CD cord-010119-t1x9gknd 5701 43 / / SYM cord-010119-t1x9gknd 5701 44 kg kg NN cord-010119-t1x9gknd 5701 45 ( ( -LRB- cord-010119-t1x9gknd 5701 46 2 2 CD cord-010119-t1x9gknd 5701 47 - - HYPH cord-010119-t1x9gknd 5701 48 30.7x10 30.7x10 CD cord-010119-t1x9gknd 5701 49 8 8 CD cord-010119-t1x9gknd 5701 50 / / SYM cord-010119-t1x9gknd 5701 51 kg kg NN cord-010119-t1x9gknd 5701 52 ) ) -RRB- cord-010119-t1x9gknd 5701 53 . . . cord-010119-t1x9gknd 5702 1 WBC WBC NNP cord-010119-t1x9gknd 5702 2 increment increment NN cord-010119-t1x9gknd 5702 3 was be VBD cord-010119-t1x9gknd 5702 4 able able JJ cord-010119-t1x9gknd 5702 5 to to TO cord-010119-t1x9gknd 5702 6 estimate estimate VB cord-010119-t1x9gknd 5702 7 after after IN cord-010119-t1x9gknd 5702 8 144 144 CD cord-010119-t1x9gknd 5702 9 transfusions transfusion NNS cord-010119-t1x9gknd 5702 10 . . . cord-010119-t1x9gknd 5703 1 WBC WBC NNP cord-010119-t1x9gknd 5703 2 increment increment NN cord-010119-t1x9gknd 5703 3 was be VBD cord-010119-t1x9gknd 5703 4 recorded record VBN cord-010119-t1x9gknd 5703 5 after after IN cord-010119-t1x9gknd 5703 6 96 96 CD cord-010119-t1x9gknd 5703 7 transfusions transfusion NNS cord-010119-t1x9gknd 5703 8 ( ( -LRB- cord-010119-t1x9gknd 5703 9 66.7 66.7 CD cord-010119-t1x9gknd 5703 10 % % NN cord-010119-t1x9gknd 5703 11 ) ) -RRB- cord-010119-t1x9gknd 5703 12 ; ; : cord-010119-t1x9gknd 5703 13 the the DT cord-010119-t1x9gknd 5703 14 mean mean JJ cord-010119-t1x9gknd 5703 15 increment increment NN cord-010119-t1x9gknd 5703 16 was be VBD cord-010119-t1x9gknd 5703 17 1,12x10 1,12x10 CD cord-010119-t1x9gknd 5703 18 9 9 CD cord-010119-t1x9gknd 5703 19 / / SYM cord-010119-t1x9gknd 5703 20 L l NN cord-010119-t1x9gknd 5703 21 ( ( -LRB- cord-010119-t1x9gknd 5703 22 0,01 0,01 CD cord-010119-t1x9gknd 5703 23 - - HYPH cord-010119-t1x9gknd 5703 24 11,38 11,38 CD cord-010119-t1x9gknd 5703 25 x10 x10 CD cord-010119-t1x9gknd 5703 26 9 9 CD cord-010119-t1x9gknd 5703 27 / / SYM cord-010119-t1x9gknd 5703 28 L L NNP cord-010119-t1x9gknd 5703 29 ) ) -RRB- cord-010119-t1x9gknd 5703 30 . . . cord-010119-t1x9gknd 5704 1 Efficacy efficacy NN cord-010119-t1x9gknd 5704 2 was be VBD cord-010119-t1x9gknd 5704 3 determined determine VBN cord-010119-t1x9gknd 5704 4 by by IN cord-010119-t1x9gknd 5704 5 the the DT cord-010119-t1x9gknd 5704 6 number number NN cord-010119-t1x9gknd 5704 7 of of IN cord-010119-t1x9gknd 5704 8 patients patient NNS cord-010119-t1x9gknd 5704 9 who who WP cord-010119-t1x9gknd 5704 10 survived survive VBD cord-010119-t1x9gknd 5704 11 an an DT cord-010119-t1x9gknd 5704 12 infection infection NN cord-010119-t1x9gknd 5704 13 episode episode NN cord-010119-t1x9gknd 5704 14 and and CC cord-010119-t1x9gknd 5704 15 amounted amount VBD cord-010119-t1x9gknd 5704 16 to to IN cord-010119-t1x9gknd 5704 17 80.6 80.6 CD cord-010119-t1x9gknd 5704 18 % % NN cord-010119-t1x9gknd 5704 19 . . . cord-010119-t1x9gknd 5705 1 In in IN cord-010119-t1x9gknd 5705 2 the the DT cord-010119-t1x9gknd 5705 3 cases case NNS cord-010119-t1x9gknd 5705 4 of of IN cord-010119-t1x9gknd 5705 5 severe severe JJ cord-010119-t1x9gknd 5705 6 sepsis sepsis NN cord-010119-t1x9gknd 5705 7 , , , cord-010119-t1x9gknd 5705 8 the the DT cord-010119-t1x9gknd 5705 9 efficacy efficacy NN cord-010119-t1x9gknd 5705 10 of of IN cord-010119-t1x9gknd 5705 11 transfusions transfusion NNS cord-010119-t1x9gknd 5705 12 was be VBD cord-010119-t1x9gknd 5705 13 76.2 76.2 CD cord-010119-t1x9gknd 5705 14 % % NN cord-010119-t1x9gknd 5705 15 . . . cord-010119-t1x9gknd 5706 1 The the DT cord-010119-t1x9gknd 5706 2 frequency frequency NN cord-010119-t1x9gknd 5706 3 of of IN cord-010119-t1x9gknd 5706 4 post post JJ cord-010119-t1x9gknd 5706 5 - - JJ cord-010119-t1x9gknd 5706 6 transfusion transfusion JJ cord-010119-t1x9gknd 5706 7 reactions reaction NNS cord-010119-t1x9gknd 5706 8 was be VBD cord-010119-t1x9gknd 5706 9 22 22 CD cord-010119-t1x9gknd 5706 10 % % NN cord-010119-t1x9gknd 5706 11 , , , cord-010119-t1x9gknd 5706 12 ( ( -LRB- cord-010119-t1x9gknd 5706 13 n n NN cord-010119-t1x9gknd 5706 14 5 5 CD cord-010119-t1x9gknd 5706 15 8) 8) NNP cord-010119-t1x9gknd 5706 16 : : : cord-010119-t1x9gknd 5707 1 febrile febrile JJ cord-010119-t1x9gknd 5707 2 nonhemolytic nonhemolytic JJ cord-010119-t1x9gknd 5707 3 reactions reaction NNS cord-010119-t1x9gknd 5707 4 8,3 8,3 CD cord-010119-t1x9gknd 5707 5 % % NN cord-010119-t1x9gknd 5707 6 ( ( -LRB- cord-010119-t1x9gknd 5707 7 n n NN cord-010119-t1x9gknd 5707 8 5 5 CD cord-010119-t1x9gknd 5707 9 3 3 CD cord-010119-t1x9gknd 5707 10 ) ) -RRB- cord-010119-t1x9gknd 5707 11 ; ; : cord-010119-t1x9gknd 5707 12 pulmonary pulmonary JJ cord-010119-t1x9gknd 5707 13 complications complication NNS cord-010119-t1x9gknd 5707 14 11,1 11,1 CD cord-010119-t1x9gknd 5707 15 % % NN cord-010119-t1x9gknd 5707 16 ( ( -LRB- cord-010119-t1x9gknd 5707 17 n n NN cord-010119-t1x9gknd 5707 18 5 5 CD cord-010119-t1x9gknd 5707 19 4 4 CD cord-010119-t1x9gknd 5707 20 ) ) -RRB- cord-010119-t1x9gknd 5708 1 ; ; : cord-010119-t1x9gknd 5708 2 the the DT cord-010119-t1x9gknd 5708 3 anti anti JJ cord-010119-t1x9gknd 5708 4 - - JJ cord-010119-t1x9gknd 5708 5 HLA HLA NNP cord-010119-t1x9gknd 5708 6 antibodies antibody NNS cord-010119-t1x9gknd 5708 7 formation formation NN cord-010119-t1x9gknd 5708 8 2,7 2,7 CD cord-010119-t1x9gknd 5708 9 % % NN cord-010119-t1x9gknd 5708 10 ( ( -LRB- cord-010119-t1x9gknd 5708 11 n n NN cord-010119-t1x9gknd 5708 12 5 5 CD cord-010119-t1x9gknd 5708 13 1 1 CD cord-010119-t1x9gknd 5708 14 ) ) -RRB- cord-010119-t1x9gknd 5709 1 Conclusion conclusion NN cord-010119-t1x9gknd 5709 2 : : : cord-010119-t1x9gknd 5710 1 No no DT cord-010119-t1x9gknd 5710 2 significant significant JJ cord-010119-t1x9gknd 5710 3 differences difference NNS cord-010119-t1x9gknd 5710 4 in in IN cord-010119-t1x9gknd 5710 5 the the DT cord-010119-t1x9gknd 5710 6 mobilization mobilization NN cord-010119-t1x9gknd 5710 7 of of IN cord-010119-t1x9gknd 5710 8 granulocytes granulocyte NNS cord-010119-t1x9gknd 5710 9 and and CC cord-010119-t1x9gknd 5710 10 products product NNS cord-010119-t1x9gknd 5710 11 ' ' POS cord-010119-t1x9gknd 5710 12 volume volume NN cord-010119-t1x9gknd 5710 13 , , , cord-010119-t1x9gknd 5710 14 between between IN cord-010119-t1x9gknd 5710 15 men man NNS cord-010119-t1x9gknd 5710 16 and and CC cord-010119-t1x9gknd 5710 17 women woman NNS cord-010119-t1x9gknd 5710 18 , , , cord-010119-t1x9gknd 5710 19 or or CC cord-010119-t1x9gknd 5710 20 between between IN cord-010119-t1x9gknd 5710 21 age age NN cord-010119-t1x9gknd 5710 22 groups group NNS cord-010119-t1x9gknd 5710 23 and and CC cord-010119-t1x9gknd 5711 1 we -PRON- PRP cord-010119-t1x9gknd 5711 2 did do VBD cord-010119-t1x9gknd 5711 3 not not RB cord-010119-t1x9gknd 5711 4 find find VB cord-010119-t1x9gknd 5711 5 significant significant JJ cord-010119-t1x9gknd 5711 6 relationship relationship NN cord-010119-t1x9gknd 5711 7 between between IN cord-010119-t1x9gknd 5711 8 baseline baseline JJ cord-010119-t1x9gknd 5711 9 WBC WBC NNP cord-010119-t1x9gknd 5711 10 and and CC cord-010119-t1x9gknd 5711 11 their -PRON- PRP$ cord-010119-t1x9gknd 5711 12 increment increment NN cord-010119-t1x9gknd 5711 13 after after IN cord-010119-t1x9gknd 5711 14 stimulation stimulation NN cord-010119-t1x9gknd 5711 15 . . . cord-010119-t1x9gknd 5712 1 The the DT cord-010119-t1x9gknd 5712 2 mean mean JJ cord-010119-t1x9gknd 5712 3 total total JJ cord-010119-t1x9gknd 5712 4 WBC WBC NNP cord-010119-t1x9gknd 5712 5 in in IN cord-010119-t1x9gknd 5712 6 the the DT cord-010119-t1x9gknd 5712 7 collected collect VBN cord-010119-t1x9gknd 5712 8 product product NN cord-010119-t1x9gknd 5712 9 and and CC cord-010119-t1x9gknd 5712 10 the the DT cord-010119-t1x9gknd 5712 11 mean mean JJ cord-010119-t1x9gknd 5712 12 volume volume NN cord-010119-t1x9gknd 5712 13 of of IN cord-010119-t1x9gknd 5712 14 treated treat VBN cord-010119-t1x9gknd 5712 15 blood blood NN cord-010119-t1x9gknd 5712 16 from from IN cord-010119-t1x9gknd 5712 17 men man NNS cord-010119-t1x9gknd 5712 18 and and CC cord-010119-t1x9gknd 5712 19 women woman NNS cord-010119-t1x9gknd 5712 20 were be VBD cord-010119-t1x9gknd 5712 21 significantly significantly RB cord-010119-t1x9gknd 5712 22 different different JJ cord-010119-t1x9gknd 5712 23 . . . cord-010119-t1x9gknd 5713 1 Perhaps perhaps RB cord-010119-t1x9gknd 5713 2 the the DT cord-010119-t1x9gknd 5713 3 reason reason NN cord-010119-t1x9gknd 5713 4 for for IN cord-010119-t1x9gknd 5713 5 lower low JJR cord-010119-t1x9gknd 5713 6 cell cell NN cord-010119-t1x9gknd 5713 7 products product NNS cord-010119-t1x9gknd 5713 8 from from IN cord-010119-t1x9gknd 5713 9 women woman NNS cord-010119-t1x9gknd 5713 10 is be VBZ cord-010119-t1x9gknd 5713 11 to to TO cord-010119-t1x9gknd 5713 12 treat treat VB cord-010119-t1x9gknd 5713 13 smaller small JJR cord-010119-t1x9gknd 5713 14 blood blood NN cord-010119-t1x9gknd 5713 15 volume volume NN cord-010119-t1x9gknd 5713 16 . . . cord-010119-t1x9gknd 5714 1 The the DT cord-010119-t1x9gknd 5714 2 lack lack NN cord-010119-t1x9gknd 5714 3 of of IN cord-010119-t1x9gknd 5714 4 increment increment NN cord-010119-t1x9gknd 5714 5 WBC WBC NNP cord-010119-t1x9gknd 5714 6 after after IN cord-010119-t1x9gknd 5714 7 transfusion transfusion NN cord-010119-t1x9gknd 5714 8 is be VBZ cord-010119-t1x9gknd 5714 9 not not RB cord-010119-t1x9gknd 5714 10 equivalent equivalent JJ cord-010119-t1x9gknd 5714 11 to to IN cord-010119-t1x9gknd 5714 12 lack lack NN cord-010119-t1x9gknd 5714 13 of of IN cord-010119-t1x9gknd 5714 14 its -PRON- PRP$ cord-010119-t1x9gknd 5714 15 efficacy efficacy NN cord-010119-t1x9gknd 5714 16 . . . cord-010119-t1x9gknd 5715 1 We -PRON- PRP cord-010119-t1x9gknd 5715 2 found find VBD cord-010119-t1x9gknd 5715 3 a a DT cord-010119-t1x9gknd 5715 4 significant significant JJ cord-010119-t1x9gknd 5715 5 association association NN cord-010119-t1x9gknd 5715 6 between between IN cord-010119-t1x9gknd 5715 7 transfused transfused JJ cord-010119-t1x9gknd 5715 8 dose dose NN cord-010119-t1x9gknd 5715 9 and and CC cord-010119-t1x9gknd 5715 10 increment increment NN cord-010119-t1x9gknd 5715 11 of of IN cord-010119-t1x9gknd 5715 12 WBC WBC NNP cord-010119-t1x9gknd 5715 13 . . . cord-010119-t1x9gknd 5716 1 We -PRON- PRP cord-010119-t1x9gknd 5716 2 deliberately deliberately RB cord-010119-t1x9gknd 5716 3 did do VBD cord-010119-t1x9gknd 5716 4 not not RB cord-010119-t1x9gknd 5716 5 estimate estimate VB cord-010119-t1x9gknd 5716 6 our -PRON- PRP$ cord-010119-t1x9gknd 5716 7 data datum NNS cord-010119-t1x9gknd 5716 8 on on IN cord-010119-t1x9gknd 5716 9 the the DT cord-010119-t1x9gknd 5716 10 treatment treatment NN cord-010119-t1x9gknd 5716 11 of of IN cord-010119-t1x9gknd 5716 12 patients patient NNS cord-010119-t1x9gknd 5716 13 with with IN cord-010119-t1x9gknd 5716 14 sepsis sepsis NN cord-010119-t1x9gknd 5716 15 and and CC cord-010119-t1x9gknd 5716 16 other other JJ cord-010119-t1x9gknd 5716 17 severe severe JJ cord-010119-t1x9gknd 5716 18 infections infection NNS cord-010119-t1x9gknd 5716 19 between between IN cord-010119-t1x9gknd 5716 20 patients patient NNS cord-010119-t1x9gknd 5716 21 receiving receive VBG cord-010119-t1x9gknd 5716 22 and and CC cord-010119-t1x9gknd 5716 23 not not RB cord-010119-t1x9gknd 5716 24 receiving receive VBG cord-010119-t1x9gknd 5716 25 granulocyte granulocyte NN cord-010119-t1x9gknd 5716 26 transfusions transfusion NNS cord-010119-t1x9gknd 5716 27 because because IN cord-010119-t1x9gknd 5716 28 the the DT cord-010119-t1x9gknd 5716 29 need need NN cord-010119-t1x9gknd 5716 30 for for IN cord-010119-t1x9gknd 5716 31 transfusions transfusion NNS cord-010119-t1x9gknd 5716 32 of of IN cord-010119-t1x9gknd 5716 33 granulocytes granulocyte NNS cord-010119-t1x9gknd 5716 34 indicates indicate VBZ cord-010119-t1x9gknd 5716 35 more more RBR cord-010119-t1x9gknd 5716 36 severe severe JJ cord-010119-t1x9gknd 5716 37 patients patient NNS cord-010119-t1x9gknd 5716 38 , , , cord-010119-t1x9gknd 5716 39 when when WRB cord-010119-t1x9gknd 5716 40 they -PRON- PRP cord-010119-t1x9gknd 5716 41 have have VBP cord-010119-t1x9gknd 5716 42 infections infection NNS cord-010119-t1x9gknd 5716 43 in in IN cord-010119-t1x9gknd 5716 44 a a DT cord-010119-t1x9gknd 5716 45 neutropenia neutropenia NN cord-010119-t1x9gknd 5716 46 or or CC cord-010119-t1x9gknd 5716 47 dysfunction dysfunction NN cord-010119-t1x9gknd 5716 48 of of IN cord-010119-t1x9gknd 5716 49 the the DT cord-010119-t1x9gknd 5716 50 immune immune JJ cord-010119-t1x9gknd 5716 51 system system NN cord-010119-t1x9gknd 5716 52 , , , cord-010119-t1x9gknd 5716 53 and and CC cord-010119-t1x9gknd 5716 54 refractory refractory JJ cord-010119-t1x9gknd 5716 55 to to IN cord-010119-t1x9gknd 5716 56 antibiotics antibiotic NNS cord-010119-t1x9gknd 5716 57 CP150 cp150 NN cord-010119-t1x9gknd 5716 58 Hemolytic hemolytic JJ cord-010119-t1x9gknd 5716 59 Disease Disease NNP cord-010119-t1x9gknd 5716 60 of of IN cord-010119-t1x9gknd 5716 61 the the DT cord-010119-t1x9gknd 5716 62 Newborn Newborn NNP cord-010119-t1x9gknd 5717 1 Due due IN cord-010119-t1x9gknd 5717 2 to to IN cord-010119-t1x9gknd 5718 1 Anti Anti NNP cord-010119-t1x9gknd 5718 2 - - NNP cord-010119-t1x9gknd 5718 3 Rh17 Rh17 NNP cord-010119-t1x9gknd 5718 4 Keegan Keegan NNP cord-010119-t1x9gknd 5718 5 Barry Barry NNP cord-010119-t1x9gknd 5718 6 - - HYPH cord-010119-t1x9gknd 5718 7 Holson Holson NNP cord-010119-t1x9gknd 5719 1 * * NFP cord-010119-t1x9gknd 5719 2 1 1 CD cord-010119-t1x9gknd 5719 3 and and CC cord-010119-t1x9gknd 5719 4 Jennifer Jennifer NNP cord-010119-t1x9gknd 5719 5 Andrews Andrews NNP cord-010119-t1x9gknd 5719 6 2 2 CD cord-010119-t1x9gknd 5719 7 . . . cord-010119-t1x9gknd 5720 1 1 1 CD cord-010119-t1x9gknd 5720 2 Stanford Stanford NNP cord-010119-t1x9gknd 5720 3 University University NNP cord-010119-t1x9gknd 5720 4 , , , cord-010119-t1x9gknd 5720 5 Dept Dept NNP cord-010119-t1x9gknd 5720 6 of of IN cord-010119-t1x9gknd 5720 7 Pathology Pathology NNP cord-010119-t1x9gknd 5720 8 , , , cord-010119-t1x9gknd 5720 9 2 2 CD cord-010119-t1x9gknd 5720 10 Stanford Stanford NNP cord-010119-t1x9gknd 5720 11 University University NNP cord-010119-t1x9gknd 5720 12 , , , cord-010119-t1x9gknd 5720 13 Dept Dept NNP cord-010119-t1x9gknd 5720 14 of of IN cord-010119-t1x9gknd 5720 15 Pathology Pathology NNP cord-010119-t1x9gknd 5720 16 & & CC cord-010119-t1x9gknd 5720 17 Pediatrics Pediatrics NNP cord-010119-t1x9gknd 5720 18 Background Background NNP cord-010119-t1x9gknd 5720 19 / / SYM cord-010119-t1x9gknd 5720 20 Case Case NNP cord-010119-t1x9gknd 5720 21 Studies Studies NNPS cord-010119-t1x9gknd 5720 22 : : : cord-010119-t1x9gknd 5720 23 Anti Anti NNP cord-010119-t1x9gknd 5720 24 - - NNP cord-010119-t1x9gknd 5720 25 Rh17 Rh17 NNP cord-010119-t1x9gknd 5720 26 is be VBZ cord-010119-t1x9gknd 5720 27 a a DT cord-010119-t1x9gknd 5720 28 rare rare JJ cord-010119-t1x9gknd 5720 29 antibody antibody NN cord-010119-t1x9gknd 5720 30 against against IN cord-010119-t1x9gknd 5720 31 a a DT cord-010119-t1x9gknd 5720 32 high high JJ cord-010119-t1x9gknd 5720 33 incidence incidence NN cord-010119-t1x9gknd 5720 34 red red JJ cord-010119-t1x9gknd 5720 35 blood blood NN cord-010119-t1x9gknd 5720 36 cell cell NN cord-010119-t1x9gknd 5720 37 ( ( -LRB- cord-010119-t1x9gknd 5720 38 RBC RBC NNP cord-010119-t1x9gknd 5720 39 ) ) -RRB- cord-010119-t1x9gknd 5720 40 antigen antigen NNP cord-010119-t1x9gknd 5720 41 ( ( -LRB- cord-010119-t1x9gknd 5720 42 Ag Ag NNP cord-010119-t1x9gknd 5720 43 ) ) -RRB- cord-010119-t1x9gknd 5720 44 present present JJ cord-010119-t1x9gknd 5720 45 in in IN cord-010119-t1x9gknd 5720 46 people people NNS cord-010119-t1x9gknd 5720 47 with with IN cord-010119-t1x9gknd 5720 48 common common JJ cord-010119-t1x9gknd 5720 49 Rh Rh NNP cord-010119-t1x9gknd 5720 50 phenotypes phenotype NNS cord-010119-t1x9gknd 5720 51 . . . cord-010119-t1x9gknd 5721 1 This this DT cord-010119-t1x9gknd 5721 2 Ag Ag NNP cord-010119-t1x9gknd 5721 3 is be VBZ cord-010119-t1x9gknd 5721 4 missing miss VBG cord-010119-t1x9gknd 5721 5 in in IN cord-010119-t1x9gknd 5721 6 individuals individual NNS cord-010119-t1x9gknd 5721 7 who who WP cord-010119-t1x9gknd 5721 8 are be VBP cord-010119-t1x9gknd 5721 9 Rh Rh NNP cord-010119-t1x9gknd 5721 10 null null JJ cord-010119-t1x9gknd 5721 11 or or CC cord-010119-t1x9gknd 5721 12 have have VB cord-010119-t1x9gknd 5721 13 Rh Rh NNP cord-010119-t1x9gknd 5721 14 deletion deletion NN cord-010119-t1x9gknd 5721 15 phenotypes phenotype NNS cord-010119-t1x9gknd 5721 16 , , , cord-010119-t1x9gknd 5721 17 including include VBG cord-010119-t1x9gknd 5721 18 D--/D-- D--/D-- NNP cord-010119-t1x9gknd 5721 19 . . . cord-010119-t1x9gknd 5722 1 D D NNP cord-010119-t1x9gknd 5722 2 -- -- : cord-010119-t1x9gknd 5722 3 individuals individual NNS cord-010119-t1x9gknd 5722 4 strongly strongly RB cord-010119-t1x9gknd 5722 5 express express VBP cord-010119-t1x9gknd 5722 6 D D NNP cord-010119-t1x9gknd 5722 7 and and CC cord-010119-t1x9gknd 5722 8 lack lack NN cord-010119-t1x9gknd 5722 9 C C NNP cord-010119-t1x9gknd 5722 10 , , , cord-010119-t1x9gknd 5722 11 c c NNP cord-010119-t1x9gknd 5722 12 , , , cord-010119-t1x9gknd 5722 13 E E NNP cord-010119-t1x9gknd 5722 14 , , , cord-010119-t1x9gknd 5722 15 and and CC cord-010119-t1x9gknd 5722 16 e e NNP cord-010119-t1x9gknd 5722 17 Ags Ags NNP cord-010119-t1x9gknd 5722 18 . . . cord-010119-t1x9gknd 5723 1 The the DT cord-010119-t1x9gknd 5723 2 clinical clinical JJ cord-010119-t1x9gknd 5723 3 relevance relevance NN cord-010119-t1x9gknd 5723 4 of of IN cord-010119-t1x9gknd 5723 5 anti anti JJ cord-010119-t1x9gknd 5723 6 - - NNP cord-010119-t1x9gknd 5723 7 RH17 RH17 NNP cord-010119-t1x9gknd 5723 8 has have VBZ cord-010119-t1x9gknd 5723 9 primarily primarily RB cord-010119-t1x9gknd 5723 10 been be VBN cord-010119-t1x9gknd 5723 11 reported report VBN cord-010119-t1x9gknd 5723 12 in in IN cord-010119-t1x9gknd 5723 13 pregnant pregnant JJ cord-010119-t1x9gknd 5723 14 women woman NNS cord-010119-t1x9gknd 5723 15 , , , cord-010119-t1x9gknd 5723 16 causing cause VBG cord-010119-t1x9gknd 5723 17 mild mild JJ cord-010119-t1x9gknd 5723 18 to to IN cord-010119-t1x9gknd 5723 19 fatal fatal JJ cord-010119-t1x9gknd 5723 20 hemolytic hemolytic JJ cord-010119-t1x9gknd 5723 21 disease disease NN cord-010119-t1x9gknd 5723 22 of of IN cord-010119-t1x9gknd 5723 23 the the DT cord-010119-t1x9gknd 5723 24 newborn newborn NN cord-010119-t1x9gknd 5723 25 ( ( -LRB- cord-010119-t1x9gknd 5723 26 HDN HDN NNP cord-010119-t1x9gknd 5723 27 ) ) -RRB- cord-010119-t1x9gknd 5723 28 . . . cord-010119-t1x9gknd 5724 1 We -PRON- PRP cord-010119-t1x9gknd 5724 2 present present VBP cord-010119-t1x9gknd 5724 3 a a DT cord-010119-t1x9gknd 5724 4 rare rare JJ cord-010119-t1x9gknd 5724 5 case case NN cord-010119-t1x9gknd 5724 6 of of IN cord-010119-t1x9gknd 5724 7 HDN HDN NNP cord-010119-t1x9gknd 5724 8 due due IN cord-010119-t1x9gknd 5724 9 to to IN cord-010119-t1x9gknd 5724 10 anti anti JJ cord-010119-t1x9gknd 5724 11 - - JJ cord-010119-t1x9gknd 5724 12 Rh17 rh17 JJ cord-010119-t1x9gknd 5724 13 alloimmunization alloimmunization NN cord-010119-t1x9gknd 5724 14 during during IN cord-010119-t1x9gknd 5724 15 pregnancy pregnancy NN cord-010119-t1x9gknd 5724 16 in in IN cord-010119-t1x9gknd 5724 17 a a DT cord-010119-t1x9gknd 5724 18 D d NN cord-010119-t1x9gknd 5724 19 -- -- : cord-010119-t1x9gknd 5724 20 mother mother NN cord-010119-t1x9gknd 5724 21 . . . cord-010119-t1x9gknd 5725 1 Study Study NNP cord-010119-t1x9gknd 5725 2 Design Design NNP cord-010119-t1x9gknd 5725 3 / / SYM cord-010119-t1x9gknd 5725 4 Methods method NNS cord-010119-t1x9gknd 5725 5 : : : cord-010119-t1x9gknd 5726 1 An an DT cord-010119-t1x9gknd 5726 2 O o NN cord-010119-t1x9gknd 5726 3 - - HYPH cord-010119-t1x9gknd 5726 4 positive positive JJ cord-010119-t1x9gknd 5726 5 full full JJ cord-010119-t1x9gknd 5726 6 term term NN cord-010119-t1x9gknd 5726 7 infant infant NN cord-010119-t1x9gknd 5726 8 was be VBD cord-010119-t1x9gknd 5726 9 born bear VBN cord-010119-t1x9gknd 5726 10 to to IN cord-010119-t1x9gknd 5726 11 an an DT cord-010119-t1x9gknd 5726 12 Opositive Opositive NNP cord-010119-t1x9gknd 5726 13 G3P1 G3P1 NNP cord-010119-t1x9gknd 5726 14 > > XX cord-010119-t1x9gknd 5726 15 2 2 CD cord-010119-t1x9gknd 5726 16 mother mother NN cord-010119-t1x9gknd 5726 17 with with IN cord-010119-t1x9gknd 5726 18 a a DT cord-010119-t1x9gknd 5726 19 negative negative JJ cord-010119-t1x9gknd 5726 20 1 1 CD cord-010119-t1x9gknd 5726 21 st st NNP cord-010119-t1x9gknd 5726 22 trimester trimester NNP cord-010119-t1x9gknd 5726 23 antibody antibody NN cord-010119-t1x9gknd 5726 24 screen screen NN cord-010119-t1x9gknd 5726 25 and and CC cord-010119-t1x9gknd 5726 26 no no DT cord-010119-t1x9gknd 5726 27 prior prior JJ cord-010119-t1x9gknd 5726 28 transfusions transfusion NNS cord-010119-t1x9gknd 5726 29 . . . cord-010119-t1x9gknd 5727 1 She -PRON- PRP cord-010119-t1x9gknd 5727 2 had have VBD cord-010119-t1x9gknd 5727 3 two two CD cord-010119-t1x9gknd 5727 4 prior prior JJ cord-010119-t1x9gknd 5727 5 pregnancies pregnancy NNS cord-010119-t1x9gknd 5727 6 , , , cord-010119-t1x9gknd 5727 7 the the DT cord-010119-t1x9gknd 5727 8 first first JJ cord-010119-t1x9gknd 5727 9 resulted result VBD cord-010119-t1x9gknd 5727 10 in in IN cord-010119-t1x9gknd 5727 11 a a DT cord-010119-t1x9gknd 5727 12 normal normal JJ cord-010119-t1x9gknd 5727 13 term term NN cord-010119-t1x9gknd 5727 14 singleton singleton JJ cord-010119-t1x9gknd 5727 15 , , , cord-010119-t1x9gknd 5727 16 and and CC cord-010119-t1x9gknd 5727 17 the the DT cord-010119-t1x9gknd 5727 18 second second JJ cord-010119-t1x9gknd 5727 19 resulted result VBD cord-010119-t1x9gknd 5727 20 in in IN cord-010119-t1x9gknd 5727 21 a a DT cord-010119-t1x9gknd 5727 22 spontaneous spontaneous JJ cord-010119-t1x9gknd 5727 23 miscarriage miscarriage NN cord-010119-t1x9gknd 5727 24 during during IN cord-010119-t1x9gknd 5727 25 the the DT cord-010119-t1x9gknd 5727 26 1 1 CD cord-010119-t1x9gknd 5727 27 st st NNP cord-010119-t1x9gknd 5727 28 trimester trimester NN cord-010119-t1x9gknd 5727 29 . . . cord-010119-t1x9gknd 5728 1 Father Father NNP cord-010119-t1x9gknd 5728 2 's 's POS cord-010119-t1x9gknd 5728 3 blood blood NN cord-010119-t1x9gknd 5728 4 type type NN cord-010119-t1x9gknd 5728 5 is be VBZ cord-010119-t1x9gknd 5728 6 unknown unknown JJ cord-010119-t1x9gknd 5728 7 but but CC cord-010119-t1x9gknd 5728 8 presumably presumably RB cord-010119-t1x9gknd 5728 9 he -PRON- PRP cord-010119-t1x9gknd 5728 10 has have VBZ cord-010119-t1x9gknd 5728 11 Rh Rh NNP cord-010119-t1x9gknd 5728 12 antigens antigen NNS cord-010119-t1x9gknd 5728 13 . . . cord-010119-t1x9gknd 5729 1 The the DT cord-010119-t1x9gknd 5729 2 infant infant NN cord-010119-t1x9gknd 5729 3 was be VBD cord-010119-t1x9gknd 5729 4 transferred transfer VBN cord-010119-t1x9gknd 5729 5 to to IN cord-010119-t1x9gknd 5729 6 our -PRON- PRP$ cord-010119-t1x9gknd 5729 7 institution institution NN cord-010119-t1x9gknd 5729 8 at at IN cord-010119-t1x9gknd 5729 9 6 6 CD cord-010119-t1x9gknd 5729 10 hours hour NNS cord-010119-t1x9gknd 5729 11 of of IN cord-010119-t1x9gknd 5729 12 life life NN cord-010119-t1x9gknd 5729 13 because because IN cord-010119-t1x9gknd 5729 14 he -PRON- PRP cord-010119-t1x9gknd 5729 15 was be VBD cord-010119-t1x9gknd 5729 16 found find VBN cord-010119-t1x9gknd 5729 17 to to TO cord-010119-t1x9gknd 5729 18 have have VB cord-010119-t1x9gknd 5729 19 anemia anemia NN cord-010119-t1x9gknd 5729 20 ( ( -LRB- cord-010119-t1x9gknd 5729 21 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5729 22 12.0 12.0 CD cord-010119-t1x9gknd 5729 23 g g NN cord-010119-t1x9gknd 5729 24 / / SYM cord-010119-t1x9gknd 5729 25 dL dl NN cord-010119-t1x9gknd 5729 26 ) ) -RRB- cord-010119-t1x9gknd 5729 27 , , , cord-010119-t1x9gknd 5729 28 severe severe JJ cord-010119-t1x9gknd 5729 29 hyperbilirubinemia hyperbilirubinemia NN cord-010119-t1x9gknd 5729 30 ( ( -LRB- cord-010119-t1x9gknd 5729 31 total total JJ cord-010119-t1x9gknd 5729 32 bilirubin bilirubin NN cord-010119-t1x9gknd 5729 33 ( ( -LRB- cord-010119-t1x9gknd 5729 34 t t NNP cord-010119-t1x9gknd 5729 35 Bili Bili NNP cord-010119-t1x9gknd 5729 36 ) ) -RRB- cord-010119-t1x9gknd 5730 1 9.0 9.0 CD cord-010119-t1x9gknd 5730 2 mg mg NN cord-010119-t1x9gknd 5730 3 / / SYM cord-010119-t1x9gknd 5730 4 dL dL NNP cord-010119-t1x9gknd 5730 5 ) ) -RRB- cord-010119-t1x9gknd 5730 6 , , , cord-010119-t1x9gknd 5730 7 reticulocytosis reticulocytosis NNP cord-010119-t1x9gknd 5730 8 ( ( -LRB- cord-010119-t1x9gknd 5730 9 8 8 CD cord-010119-t1x9gknd 5730 10 % % NN cord-010119-t1x9gknd 5730 11 ) ) -RRB- cord-010119-t1x9gknd 5730 12 and and CC cord-010119-t1x9gknd 5730 13 a a DT cord-010119-t1x9gknd 5730 14 positive positive JJ cord-010119-t1x9gknd 5730 15 direct direct JJ cord-010119-t1x9gknd 5730 16 antiglobulin antiglobulin NN cord-010119-t1x9gknd 5730 17 test test NN cord-010119-t1x9gknd 5730 18 ( ( -LRB- cord-010119-t1x9gknd 5730 19 IgG IgG NNP cord-010119-t1x9gknd 5730 20 21 21 CD cord-010119-t1x9gknd 5730 21 ) ) -RRB- cord-010119-t1x9gknd 5730 22 . . . cord-010119-t1x9gknd 5731 1 He -PRON- PRP cord-010119-t1x9gknd 5731 2 was be VBD cord-010119-t1x9gknd 5731 3 admitted admit VBN cord-010119-t1x9gknd 5731 4 to to IN cord-010119-t1x9gknd 5731 5 our -PRON- PRP$ cord-010119-t1x9gknd 5731 6 neonatal neonatal JJ cord-010119-t1x9gknd 5731 7 intensive intensive JJ cord-010119-t1x9gknd 5731 8 care care NN cord-010119-t1x9gknd 5731 9 unit unit NN cord-010119-t1x9gknd 5731 10 for for IN cord-010119-t1x9gknd 5731 11 potential potential JJ cord-010119-t1x9gknd 5731 12 need need NN cord-010119-t1x9gknd 5731 13 for for IN cord-010119-t1x9gknd 5731 14 exchange exchange NN cord-010119-t1x9gknd 5731 15 transfusion transfusion NN cord-010119-t1x9gknd 5731 16 given give VBN cord-010119-t1x9gknd 5731 17 concern concern NN cord-010119-t1x9gknd 5731 18 for for IN cord-010119-t1x9gknd 5731 19 HDN HDN NNP cord-010119-t1x9gknd 5731 20 . . . cord-010119-t1x9gknd 5732 1 He -PRON- PRP cord-010119-t1x9gknd 5732 2 was be VBD cord-010119-t1x9gknd 5732 3 treated treat VBN cord-010119-t1x9gknd 5732 4 with with IN cord-010119-t1x9gknd 5732 5 intravenous intravenous JJ cord-010119-t1x9gknd 5732 6 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 5732 7 and and CC cord-010119-t1x9gknd 5732 8 triple triple JJ cord-010119-t1x9gknd 5732 9 phototherapy phototherapy NN cord-010119-t1x9gknd 5732 10 on on IN cord-010119-t1x9gknd 5732 11 the the DT cord-010119-t1x9gknd 5732 12 day day NN cord-010119-t1x9gknd 5732 13 of of IN cord-010119-t1x9gknd 5732 14 admission admission NN cord-010119-t1x9gknd 5732 15 , , , cord-010119-t1x9gknd 5732 16 temporarily temporarily RB cord-010119-t1x9gknd 5732 17 blunting blunt VBG cord-010119-t1x9gknd 5732 18 his -PRON- PRP$ cord-010119-t1x9gknd 5732 19 hemolysis hemolysis NN cord-010119-t1x9gknd 5732 20 . . . cord-010119-t1x9gknd 5733 1 T T NNP cord-010119-t1x9gknd 5733 2 bili bili NNP cord-010119-t1x9gknd 5733 3 rose rise VBD cord-010119-t1x9gknd 5733 4 to to IN cord-010119-t1x9gknd 5733 5 a a DT cord-010119-t1x9gknd 5733 6 maximum maximum NN cord-010119-t1x9gknd 5733 7 of of IN cord-010119-t1x9gknd 5733 8 16.7 16.7 CD cord-010119-t1x9gknd 5733 9 mg mg NNS cord-010119-t1x9gknd 5734 1 /dL /dL NFP cord-010119-t1x9gknd 5734 2 on on IN cord-010119-t1x9gknd 5734 3 day day NN cord-010119-t1x9gknd 5734 4 8 8 CD cord-010119-t1x9gknd 5734 5 of of IN cord-010119-t1x9gknd 5734 6 life life NN cord-010119-t1x9gknd 5734 7 and and CC cord-010119-t1x9gknd 5734 8 phototherapy phototherapy NN cord-010119-t1x9gknd 5734 9 was be VBD cord-010119-t1x9gknd 5734 10 restarted restart VBN cord-010119-t1x9gknd 5734 11 . . . cord-010119-t1x9gknd 5735 1 His -PRON- PRP$ cord-010119-t1x9gknd 5735 2 t t NNP cord-010119-t1x9gknd 5735 3 bili bili NNP cord-010119-t1x9gknd 5735 4 subsequently subsequently RB cord-010119-t1x9gknd 5735 5 stabilized stabilize VBD cord-010119-t1x9gknd 5735 6 and and CC cord-010119-t1x9gknd 5735 7 he -PRON- PRP cord-010119-t1x9gknd 5735 8 was be VBD cord-010119-t1x9gknd 5735 9 discharged discharge VBN cord-010119-t1x9gknd 5735 10 home home RB cord-010119-t1x9gknd 5735 11 and and CC cord-010119-t1x9gknd 5735 12 followed follow VBD cord-010119-t1x9gknd 5735 13 in in IN cord-010119-t1x9gknd 5735 14 clinic clinic NN cord-010119-t1x9gknd 5735 15 . . . cord-010119-t1x9gknd 5736 1 Meanwhile meanwhile RB cord-010119-t1x9gknd 5736 2 , , , cord-010119-t1x9gknd 5736 3 his -PRON- PRP$ cord-010119-t1x9gknd 5736 4 mother mother NN cord-010119-t1x9gknd 5736 5 donated donate VBD cord-010119-t1x9gknd 5736 6 blood blood NN cord-010119-t1x9gknd 5736 7 given give VBN cord-010119-t1x9gknd 5736 8 there there EX cord-010119-t1x9gknd 5736 9 were be VBD cord-010119-t1x9gknd 5736 10 no no DT cord-010119-t1x9gknd 5736 11 compatible compatible JJ cord-010119-t1x9gknd 5736 12 red red JJ cord-010119-t1x9gknd 5736 13 blood blood NN cord-010119-t1x9gknd 5736 14 cells cell NNS cord-010119-t1x9gknd 5736 15 available available JJ cord-010119-t1x9gknd 5736 16 in in IN cord-010119-t1x9gknd 5736 17 the the DT cord-010119-t1x9gknd 5736 18 United United NNP cord-010119-t1x9gknd 5736 19 States States NNP cord-010119-t1x9gknd 5736 20 via via IN cord-010119-t1x9gknd 5736 21 rare rare JJ cord-010119-t1x9gknd 5736 22 donor donor NN cord-010119-t1x9gknd 5736 23 query query NN cord-010119-t1x9gknd 5736 24 . . . cord-010119-t1x9gknd 5737 1 Nine nine CD cord-010119-t1x9gknd 5737 2 days day NNS cord-010119-t1x9gknd 5737 3 after after IN cord-010119-t1x9gknd 5737 4 discharge discharge NN cord-010119-t1x9gknd 5737 5 , , , cord-010119-t1x9gknd 5737 6 he -PRON- PRP cord-010119-t1x9gknd 5737 7 was be VBD cord-010119-t1x9gknd 5737 8 readmitted readmitte VBN cord-010119-t1x9gknd 5737 9 for for IN cord-010119-t1x9gknd 5737 10 worsening worsen VBG cord-010119-t1x9gknd 5737 11 anemia anemia NN cord-010119-t1x9gknd 5737 12 ( ( -LRB- cord-010119-t1x9gknd 5737 13 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5737 14 6.3 6.3 CD cord-010119-t1x9gknd 5737 15 g g NN cord-010119-t1x9gknd 5737 16 / / SYM cord-010119-t1x9gknd 5737 17 dL dl NN cord-010119-t1x9gknd 5737 18 ) ) -RRB- cord-010119-t1x9gknd 5737 19 and and CC cord-010119-t1x9gknd 5737 20 was be VBD cord-010119-t1x9gknd 5737 21 given give VBN cord-010119-t1x9gknd 5737 22 steroids steroid NNS cord-010119-t1x9gknd 5737 23 and and CC cord-010119-t1x9gknd 5737 24 washed wash VBN cord-010119-t1x9gknd 5737 25 maternal maternal JJ cord-010119-t1x9gknd 5737 26 red red JJ cord-010119-t1x9gknd 5737 27 blood blood NN cord-010119-t1x9gknd 5737 28 cells cell NNS cord-010119-t1x9gknd 5737 29 . . . cord-010119-t1x9gknd 5738 1 He -PRON- PRP cord-010119-t1x9gknd 5738 2 was be VBD cord-010119-t1x9gknd 5738 3 discharged discharge VBN cord-010119-t1x9gknd 5738 4 and and CC cord-010119-t1x9gknd 5738 5 followed follow VBN cord-010119-t1x9gknd 5738 6 in in IN cord-010119-t1x9gknd 5738 7 clinic clinic NN cord-010119-t1x9gknd 5738 8 for for IN cord-010119-t1x9gknd 5738 9 several several JJ cord-010119-t1x9gknd 5738 10 months month NNS cord-010119-t1x9gknd 5738 11 with with IN cord-010119-t1x9gknd 5738 12 ultimate ultimate JJ cord-010119-t1x9gknd 5738 13 resolution resolution NN cord-010119-t1x9gknd 5738 14 of of IN cord-010119-t1x9gknd 5738 15 his -PRON- PRP$ cord-010119-t1x9gknd 5738 16 anemia anemia NN cord-010119-t1x9gknd 5738 17 and and CC cord-010119-t1x9gknd 5738 18 hyperbilirubinemia hyperbilirubinemia NN cord-010119-t1x9gknd 5738 19 . . . cord-010119-t1x9gknd 5739 1 Results result NNS cord-010119-t1x9gknd 5739 2 / / SYM cord-010119-t1x9gknd 5739 3 Findings finding NNS cord-010119-t1x9gknd 5739 4 : : : cord-010119-t1x9gknd 5740 1 At at IN cord-010119-t1x9gknd 5740 2 delivery delivery NN cord-010119-t1x9gknd 5740 3 , , , cord-010119-t1x9gknd 5740 4 the the DT cord-010119-t1x9gknd 5740 5 mother mother NN cord-010119-t1x9gknd 5740 6 's 's POS cord-010119-t1x9gknd 5740 7 antibody antibody NN cord-010119-t1x9gknd 5740 8 screen screen NN cord-010119-t1x9gknd 5740 9 was be VBD cord-010119-t1x9gknd 5740 10 positive positive JJ cord-010119-t1x9gknd 5740 11 and and CC cord-010119-t1x9gknd 5740 12 anti anti JJ cord-010119-t1x9gknd 5740 13 - - NN cord-010119-t1x9gknd 5740 14 Rh17 Rh17 NNP cord-010119-t1x9gknd 5740 15 was be VBD cord-010119-t1x9gknd 5740 16 identified identify VBN cord-010119-t1x9gknd 5740 17 ; ; : cord-010119-t1x9gknd 5740 18 no no DT cord-010119-t1x9gknd 5740 19 other other JJ cord-010119-t1x9gknd 5740 20 alloantibodies alloantibody NNS cord-010119-t1x9gknd 5740 21 were be VBD cord-010119-t1x9gknd 5740 22 detected detect VBN cord-010119-t1x9gknd 5740 23 . . . cord-010119-t1x9gknd 5741 1 Antibody antibody NN cord-010119-t1x9gknd 5741 2 identification identification NN cord-010119-t1x9gknd 5741 3 was be VBD cord-010119-t1x9gknd 5741 4 performed perform VBN cord-010119-t1x9gknd 5741 5 using use VBG cord-010119-t1x9gknd 5741 6 polyethylene polyethylene NN cord-010119-t1x9gknd 5741 7 glycol glycol NN cord-010119-t1x9gknd 5741 8 , , , cord-010119-t1x9gknd 5741 9 low low JJ cord-010119-t1x9gknd 5741 10 ionic ionic JJ cord-010119-t1x9gknd 5741 11 strength strength NN cord-010119-t1x9gknd 5741 12 solution solution NN cord-010119-t1x9gknd 5741 13 and and CC cord-010119-t1x9gknd 5741 14 ficin ficin NNS cord-010119-t1x9gknd 5741 15 enhancement enhancement NN cord-010119-t1x9gknd 5741 16 . . . cord-010119-t1x9gknd 5742 1 Maternal maternal JJ cord-010119-t1x9gknd 5742 2 serum serum NN cord-010119-t1x9gknd 5742 3 was be VBD cord-010119-t1x9gknd 5742 4 pan pan NNP cord-010119-t1x9gknd 5742 5 reactive reactive JJ cord-010119-t1x9gknd 5742 6 against against IN cord-010119-t1x9gknd 5742 7 panel panel NN cord-010119-t1x9gknd 5742 8 cells cell NNS cord-010119-t1x9gknd 5742 9 and and CC cord-010119-t1x9gknd 5742 10 non non JJ cord-010119-t1x9gknd 5742 11 - - JJ cord-010119-t1x9gknd 5742 12 reactive reactive JJ cord-010119-t1x9gknd 5742 13 against against IN cord-010119-t1x9gknd 5742 14 D d NN cord-010119-t1x9gknd 5742 15 -- -- : cord-010119-t1x9gknd 5742 16 cells cell NNS cord-010119-t1x9gknd 5742 17 . . . cord-010119-t1x9gknd 5743 1 Anti Anti NNP cord-010119-t1x9gknd 5743 2 - - NNP cord-010119-t1x9gknd 5743 3 Rh17 Rh17 NNP cord-010119-t1x9gknd 5743 4 sera sera NNP cord-010119-t1x9gknd 5743 5 did do VBD cord-010119-t1x9gknd 5743 6 not not RB cord-010119-t1x9gknd 5743 7 react react VB cord-010119-t1x9gknd 5743 8 against against IN cord-010119-t1x9gknd 5743 9 maternal maternal JJ cord-010119-t1x9gknd 5743 10 RBCs rbc NNS cord-010119-t1x9gknd 5743 11 . . . cord-010119-t1x9gknd 5744 1 Phenotyping phenotyping NN cord-010119-t1x9gknd 5744 2 of of IN cord-010119-t1x9gknd 5744 3 the the DT cord-010119-t1x9gknd 5744 4 mother mother NN cord-010119-t1x9gknd 5744 5 revealed reveal VBD cord-010119-t1x9gknd 5744 6 that that IN cord-010119-t1x9gknd 5744 7 she -PRON- PRP cord-010119-t1x9gknd 5744 8 was be VBD cord-010119-t1x9gknd 5744 9 D1 D1 NNP cord-010119-t1x9gknd 5744 10 C C NNP cord-010119-t1x9gknd 5744 11 - - HYPH cord-010119-t1x9gknd 5744 12 E e NN cord-010119-t1x9gknd 5744 13 - - HYPH cord-010119-t1x9gknd 5744 14 c c NN cord-010119-t1x9gknd 5744 15 - - : cord-010119-t1x9gknd 5744 16 e- e- XX cord-010119-t1x9gknd 5744 17 . . . cord-010119-t1x9gknd 5745 1 Molecular molecular JJ cord-010119-t1x9gknd 5745 2 testing testing NN cord-010119-t1x9gknd 5745 3 confirmed confirm VBD cord-010119-t1x9gknd 5745 4 her -PRON- PRP$ cord-010119-t1x9gknd 5745 5 D d NN cord-010119-t1x9gknd 5745 6 -- -- : cord-010119-t1x9gknd 5745 7 genotype genotype NN cord-010119-t1x9gknd 5745 8 ; ; : cord-010119-t1x9gknd 5745 9 Molecular Molecular NNP cord-010119-t1x9gknd 5745 10 BeadChip BeadChip NNP cord-010119-t1x9gknd 5745 11 Test Test NNP cord-010119-t1x9gknd 5745 12 yielded yield VBD cord-010119-t1x9gknd 5745 13 no no DT cord-010119-t1x9gknd 5745 14 type type NN cord-010119-t1x9gknd 5745 15 due due IN cord-010119-t1x9gknd 5745 16 to to IN cord-010119-t1x9gknd 5745 17 low low JJ cord-010119-t1x9gknd 5745 18 signal signal NN cord-010119-t1x9gknd 5745 19 for for IN cord-010119-t1x9gknd 5745 20 e e NN cord-010119-t1x9gknd 5745 21 , , , cord-010119-t1x9gknd 5745 22 E E NNP cord-010119-t1x9gknd 5745 23 , , , cord-010119-t1x9gknd 5745 24 V V NNP cord-010119-t1x9gknd 5745 25 and and CC cord-010119-t1x9gknd 5745 26 VS VS NNP cord-010119-t1x9gknd 5745 27 Ags Ags NNP cord-010119-t1x9gknd 5745 28 . . . cord-010119-t1x9gknd 5746 1 Genotyping genotype VBG cord-010119-t1x9gknd 5746 2 for for IN cord-010119-t1x9gknd 5746 3 Rh Rh NNP cord-010119-t1x9gknd 5746 4 variant variant NN cord-010119-t1x9gknd 5746 5 and and CC cord-010119-t1x9gknd 5746 6 targeted target VBD cord-010119-t1x9gknd 5746 7 genomic genomic JJ cord-010119-t1x9gknd 5746 8 RHCE RHCE NNP cord-010119-t1x9gknd 5746 9 testing testing NN cord-010119-t1x9gknd 5746 10 failed fail VBD cord-010119-t1x9gknd 5746 11 to to TO cord-010119-t1x9gknd 5746 12 detect detect VB cord-010119-t1x9gknd 5746 13 several several JJ cord-010119-t1x9gknd 5746 14 RHCE RHCE NNP cord-010119-t1x9gknd 5746 15 exons exon NNS cord-010119-t1x9gknd 5746 16 . . . cord-010119-t1x9gknd 5747 1 Father Father NNP cord-010119-t1x9gknd 5747 2 was be VBD cord-010119-t1x9gknd 5747 3 unavailable unavailable JJ cord-010119-t1x9gknd 5747 4 for for IN cord-010119-t1x9gknd 5747 5 further further JJ cord-010119-t1x9gknd 5747 6 testing testing NN cord-010119-t1x9gknd 5747 7 . . . cord-010119-t1x9gknd 5748 1 Conclusion conclusion NN cord-010119-t1x9gknd 5748 2 : : : cord-010119-t1x9gknd 5748 3 We -PRON- PRP cord-010119-t1x9gknd 5748 4 report report VBP cord-010119-t1x9gknd 5748 5 a a DT cord-010119-t1x9gknd 5748 6 rare rare JJ cord-010119-t1x9gknd 5748 7 case case NN cord-010119-t1x9gknd 5748 8 of of IN cord-010119-t1x9gknd 5748 9 HDN HDN NNP cord-010119-t1x9gknd 5748 10 due due IN cord-010119-t1x9gknd 5748 11 to to IN cord-010119-t1x9gknd 5748 12 anti anti JJ cord-010119-t1x9gknd 5748 13 - - JJ cord-010119-t1x9gknd 5748 14 Rh17 Rh17 NNP cord-010119-t1x9gknd 5748 15 antibody antibody NN cord-010119-t1x9gknd 5748 16 in in IN cord-010119-t1x9gknd 5748 17 a a DT cord-010119-t1x9gknd 5748 18 D d NN cord-010119-t1x9gknd 5748 19 --mother --mother NN cord-010119-t1x9gknd 5748 20 . . . cord-010119-t1x9gknd 5749 1 We -PRON- PRP cord-010119-t1x9gknd 5749 2 hope hope VBP cord-010119-t1x9gknd 5749 3 to to TO cord-010119-t1x9gknd 5749 4 obtain obtain VB cord-010119-t1x9gknd 5749 5 further further JJ cord-010119-t1x9gknd 5749 6 laboratory laboratory NN cord-010119-t1x9gknd 5749 7 studies study NNS cord-010119-t1x9gknd 5749 8 in in IN cord-010119-t1x9gknd 5749 9 maternal maternal JJ cord-010119-t1x9gknd 5749 10 relatives relative NNS cord-010119-t1x9gknd 5749 11 given give VBN cord-010119-t1x9gknd 5749 12 the the DT cord-010119-t1x9gknd 5749 13 rarity rarity NN cord-010119-t1x9gknd 5749 14 of of IN cord-010119-t1x9gknd 5749 15 this this DT cord-010119-t1x9gknd 5749 16 phenotype phenotype NN cord-010119-t1x9gknd 5749 17 in in IN cord-010119-t1x9gknd 5749 18 the the DT cord-010119-t1x9gknd 5749 19 general general JJ cord-010119-t1x9gknd 5749 20 population population NN cord-010119-t1x9gknd 5749 21 . . . cord-010119-t1x9gknd 5750 1 These these DT cord-010119-t1x9gknd 5750 2 studies study NNS cord-010119-t1x9gknd 5750 3 have have VBP cord-010119-t1x9gknd 5750 4 important important JJ cord-010119-t1x9gknd 5750 5 implications implication NNS cord-010119-t1x9gknd 5750 6 for for IN cord-010119-t1x9gknd 5750 7 genetic genetic JJ cord-010119-t1x9gknd 5750 8 counseling counseling NN cord-010119-t1x9gknd 5750 9 for for IN cord-010119-t1x9gknd 5750 10 mother mother NN cord-010119-t1x9gknd 5750 11 's 's POS cord-010119-t1x9gknd 5750 12 sisters sister NNS cord-010119-t1x9gknd 5750 13 . . . cord-010119-t1x9gknd 5751 1 Management management NN cord-010119-t1x9gknd 5751 2 of of IN cord-010119-t1x9gknd 5751 3 Severe Severe NNP cord-010119-t1x9gknd 5751 4 Autoimmune Autoimmune NNP cord-010119-t1x9gknd 5751 5 Hemolytic hemolytic JJ cord-010119-t1x9gknd 5751 6 Anemia anemia NN cord-010119-t1x9gknd 5751 7 : : : cord-010119-t1x9gknd 5751 8 A a DT cord-010119-t1x9gknd 5751 9 Case Case NNP cord-010119-t1x9gknd 5751 10 Report Report NNP cord-010119-t1x9gknd 5751 11 of of IN cord-010119-t1x9gknd 5751 12 an an DT cord-010119-t1x9gknd 5751 13 Infant Infant NNP cord-010119-t1x9gknd 5751 14 Treated treat VBN cord-010119-t1x9gknd 5751 15 with with IN cord-010119-t1x9gknd 5751 16 Manual Manual NNP cord-010119-t1x9gknd 5751 17 Whole Whole NNP cord-010119-t1x9gknd 5751 18 Blood Blood NNP cord-010119-t1x9gknd 5751 19 Exchange Exchange NNP cord-010119-t1x9gknd 5751 20 with with IN cord-010119-t1x9gknd 5751 21 Rapid Rapid NNP cord-010119-t1x9gknd 5751 22 Clinical Clinical NNP cord-010119-t1x9gknd 5751 23 Improvement Improvement NNP cord-010119-t1x9gknd 5751 24 Yunchuan Yunchuan NNP cord-010119-t1x9gknd 5751 25 Delores Delores NNP cord-010119-t1x9gknd 5751 26 Mo Mo NNP cord-010119-t1x9gknd 5752 1 * * NFP cord-010119-t1x9gknd 5752 2 1 1 CD cord-010119-t1x9gknd 5752 3 , , , cord-010119-t1x9gknd 5752 4 Cyril Cyril NNP cord-010119-t1x9gknd 5752 5 Jacquot Jacquot NNP cord-010119-t1x9gknd 5752 6 1 1 CD cord-010119-t1x9gknd 5752 7 , , , cord-010119-t1x9gknd 5752 8 Valli Valli NNP cord-010119-t1x9gknd 5752 9 Criss Criss NNP cord-010119-t1x9gknd 5752 10 1 1 CD cord-010119-t1x9gknd 5752 11 , , , cord-010119-t1x9gknd 5752 12 Philippe Philippe NNP cord-010119-t1x9gknd 5752 13 P P NNP cord-010119-t1x9gknd 5752 14 Pary Pary NNP cord-010119-t1x9gknd 5752 15 1 1 CD cord-010119-t1x9gknd 5752 16 , , , cord-010119-t1x9gknd 5752 17 Jay Jay NNP cord-010119-t1x9gknd 5752 18 Greenberg Greenberg NNP cord-010119-t1x9gknd 5752 19 1 1 CD cord-010119-t1x9gknd 5752 20 , , , cord-010119-t1x9gknd 5752 21 Naomi Naomi NNP cord-010119-t1x9gknd 5752 22 LC LC NNP cord-010119-t1x9gknd 5752 23 Luban Luban NNP cord-010119-t1x9gknd 5752 24 1 1 CD cord-010119-t1x9gknd 5752 25 and and CC cord-010119-t1x9gknd 5752 26 Edward Edward NNP cord-010119-t1x9gknd 5752 27 CC CC NNP cord-010119-t1x9gknd 5752 28 Wong Wong NNP cord-010119-t1x9gknd 5752 29 2 2 CD cord-010119-t1x9gknd 5752 30 . . . cord-010119-t1x9gknd 5753 1 1 1 LS cord-010119-t1x9gknd 5754 1 Children child NNS cord-010119-t1x9gknd 5754 2 's 's POS cord-010119-t1x9gknd 5754 3 National National NNP cord-010119-t1x9gknd 5754 4 Medical Medical NNP cord-010119-t1x9gknd 5754 5 Center Center NNP cord-010119-t1x9gknd 5754 6 , , , cord-010119-t1x9gknd 5754 7 2 2 CD cord-010119-t1x9gknd 5754 8 Quest Quest NNP cord-010119-t1x9gknd 5754 9 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 5754 10 Background Background NNP cord-010119-t1x9gknd 5754 11 / / SYM cord-010119-t1x9gknd 5754 12 Case Case NNP cord-010119-t1x9gknd 5754 13 Studies Studies NNPS cord-010119-t1x9gknd 5754 14 : : : cord-010119-t1x9gknd 5754 15 Management management NN cord-010119-t1x9gknd 5754 16 of of IN cord-010119-t1x9gknd 5754 17 severe severe JJ cord-010119-t1x9gknd 5754 18 autoimmune autoimmune JJ cord-010119-t1x9gknd 5754 19 hemolytic hemolytic JJ cord-010119-t1x9gknd 5754 20 anemia anemia NN cord-010119-t1x9gknd 5754 21 ( ( -LRB- cord-010119-t1x9gknd 5754 22 AIHA AIHA NNP cord-010119-t1x9gknd 5754 23 ) ) -RRB- cord-010119-t1x9gknd 5754 24 presenting present VBG cord-010119-t1x9gknd 5754 25 with with IN cord-010119-t1x9gknd 5754 26 life life NN cord-010119-t1x9gknd 5754 27 - - HYPH cord-010119-t1x9gknd 5754 28 threatening threaten VBG cord-010119-t1x9gknd 5754 29 anemia anemia NN cord-010119-t1x9gknd 5754 30 is be VBZ cord-010119-t1x9gknd 5754 31 challenging challenging JJ cord-010119-t1x9gknd 5754 32 , , , cord-010119-t1x9gknd 5754 33 particularly particularly RB cord-010119-t1x9gknd 5754 34 in in IN cord-010119-t1x9gknd 5754 35 the the DT cord-010119-t1x9gknd 5754 36 pediatric pediatric JJ cord-010119-t1x9gknd 5754 37 population population NN cord-010119-t1x9gknd 5754 38 . . . cord-010119-t1x9gknd 5755 1 Mortality mortality NN cord-010119-t1x9gknd 5755 2 rates rate NNS cord-010119-t1x9gknd 5755 3 in in IN cord-010119-t1x9gknd 5755 4 AIHA AIHA NNP cord-010119-t1x9gknd 5755 5 are be VBP cord-010119-t1x9gknd 5755 6 typically typically RB cord-010119-t1x9gknd 5755 7 low low JJ cord-010119-t1x9gknd 5755 8 ; ; : cord-010119-t1x9gknd 5755 9 however however RB cord-010119-t1x9gknd 5755 10 , , , cord-010119-t1x9gknd 5755 11 in in IN cord-010119-t1x9gknd 5755 12 children child NNS cord-010119-t1x9gknd 5755 13 , , , cord-010119-t1x9gknd 5755 14 the the DT cord-010119-t1x9gknd 5755 15 rate rate NN cord-010119-t1x9gknd 5755 16 may may MD cord-010119-t1x9gknd 5755 17 be be VB cord-010119-t1x9gknd 5755 18 as as RB cord-010119-t1x9gknd 5755 19 high high JJ cord-010119-t1x9gknd 5755 20 as as IN cord-010119-t1x9gknd 5755 21 4 4 CD cord-010119-t1x9gknd 5755 22 - - SYM cord-010119-t1x9gknd 5755 23 11 11 CD cord-010119-t1x9gknd 5755 24 % % NN cord-010119-t1x9gknd 5755 25 . . . cord-010119-t1x9gknd 5756 1 Although although IN cord-010119-t1x9gknd 5756 2 corticosteroids corticosteroid NNS cord-010119-t1x9gknd 5756 3 and and CC cord-010119-t1x9gknd 5756 4 immunomodulatory immunomodulatory JJ cord-010119-t1x9gknd 5756 5 therapies therapy NNS cord-010119-t1x9gknd 5756 6 are be VBP cord-010119-t1x9gknd 5756 7 first first JJ cord-010119-t1x9gknd 5756 8 line line NN cord-010119-t1x9gknd 5756 9 modalities modality NNS cord-010119-t1x9gknd 5756 10 , , , cord-010119-t1x9gknd 5756 11 several several JJ cord-010119-t1x9gknd 5756 12 case case NN cord-010119-t1x9gknd 5756 13 reports report NNS cord-010119-t1x9gknd 5756 14 describe describe VBP cord-010119-t1x9gknd 5756 15 the the DT cord-010119-t1x9gknd 5756 16 use use NN cord-010119-t1x9gknd 5756 17 of of IN cord-010119-t1x9gknd 5756 18 manual manual JJ cord-010119-t1x9gknd 5756 19 whole whole JJ cord-010119-t1x9gknd 5756 20 blood blood NN cord-010119-t1x9gknd 5756 21 exchange exchange NN cord-010119-t1x9gknd 5756 22 ( ( -LRB- cord-010119-t1x9gknd 5756 23 WBEX WBEX NNP cord-010119-t1x9gknd 5756 24 ) ) -RRB- cord-010119-t1x9gknd 5756 25 to to TO cord-010119-t1x9gknd 5756 26 successfully successfully RB cord-010119-t1x9gknd 5756 27 treat treat VB cord-010119-t1x9gknd 5756 28 AIHA AIHA NNP cord-010119-t1x9gknd 5756 29 in in IN cord-010119-t1x9gknd 5756 30 older old JJR cord-010119-t1x9gknd 5756 31 children child NNS cord-010119-t1x9gknd 5756 32 and and CC cord-010119-t1x9gknd 5756 33 adults adult NNS cord-010119-t1x9gknd 5756 34 refractory refractory JJ cord-010119-t1x9gknd 5756 35 to to IN cord-010119-t1x9gknd 5756 36 first first JJ cord-010119-t1x9gknd 5756 37 line line NN cord-010119-t1x9gknd 5756 38 treatment treatment NN cord-010119-t1x9gknd 5756 39 . . . cord-010119-t1x9gknd 5757 1 To to IN cord-010119-t1x9gknd 5757 2 our -PRON- PRP$ cord-010119-t1x9gknd 5757 3 knowledge knowledge NN cord-010119-t1x9gknd 5757 4 , , , cord-010119-t1x9gknd 5757 5 this this DT cord-010119-t1x9gknd 5757 6 is be VBZ cord-010119-t1x9gknd 5757 7 the the DT cord-010119-t1x9gknd 5757 8 first first JJ cord-010119-t1x9gknd 5757 9 case case NN cord-010119-t1x9gknd 5757 10 report report NN cord-010119-t1x9gknd 5757 11 in in IN cord-010119-t1x9gknd 5757 12 which which WDT cord-010119-t1x9gknd 5757 13 an an DT cord-010119-t1x9gknd 5757 14 infant infant NN cord-010119-t1x9gknd 5757 15 with with IN cord-010119-t1x9gknd 5757 16 severe severe JJ cord-010119-t1x9gknd 5757 17 AIHA AIHA NNP cord-010119-t1x9gknd 5757 18 has have VBZ cord-010119-t1x9gknd 5757 19 been be VBN cord-010119-t1x9gknd 5757 20 successfully successfully RB cord-010119-t1x9gknd 5757 21 treated treat VBN cord-010119-t1x9gknd 5757 22 with with IN cord-010119-t1x9gknd 5757 23 manual manual JJ cord-010119-t1x9gknd 5757 24 WBEX WBEX NNP cord-010119-t1x9gknd 5757 25 in in IN cord-010119-t1x9gknd 5757 26 an an DT cord-010119-t1x9gknd 5757 27 acute acute JJ cord-010119-t1x9gknd 5757 28 care care NN cord-010119-t1x9gknd 5757 29 setting setting NN cord-010119-t1x9gknd 5757 30 . . . cord-010119-t1x9gknd 5758 1 Study Study NNP cord-010119-t1x9gknd 5758 2 Design Design NNP cord-010119-t1x9gknd 5758 3 / / SYM cord-010119-t1x9gknd 5758 4 Methods method NNS cord-010119-t1x9gknd 5758 5 : : : cord-010119-t1x9gknd 5759 1 Case case NN cord-010119-t1x9gknd 5759 2 report report NN cord-010119-t1x9gknd 5759 3 format format NN cord-010119-t1x9gknd 5759 4 . . . cord-010119-t1x9gknd 5760 1 Results result NNS cord-010119-t1x9gknd 5760 2 / / SYM cord-010119-t1x9gknd 5760 3 Findings finding NNS cord-010119-t1x9gknd 5760 4 : : : cord-010119-t1x9gknd 5761 1 A a DT cord-010119-t1x9gknd 5761 2 2 2 CD cord-010119-t1x9gknd 5761 3 month month NN cord-010119-t1x9gknd 5761 4 - - HYPH cord-010119-t1x9gknd 5761 5 old old JJ cord-010119-t1x9gknd 5761 6 previously previously RB cord-010119-t1x9gknd 5761 7 healthy healthy JJ cord-010119-t1x9gknd 5761 8 female female JJ cord-010119-t1x9gknd 5761 9 patient patient NN cord-010119-t1x9gknd 5761 10 presented present VBN cord-010119-t1x9gknd 5761 11 to to IN cord-010119-t1x9gknd 5761 12 the the DT cord-010119-t1x9gknd 5761 13 emergency emergency NN cord-010119-t1x9gknd 5761 14 department department NN cord-010119-t1x9gknd 5761 15 with with IN cord-010119-t1x9gknd 5761 16 hemodynamic hemodynamic JJ cord-010119-t1x9gknd 5761 17 instability instability NN cord-010119-t1x9gknd 5761 18 and and CC cord-010119-t1x9gknd 5761 19 a a DT cord-010119-t1x9gknd 5761 20 nadir nadir JJ cord-010119-t1x9gknd 5761 21 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5761 22 ( ( -LRB- cord-010119-t1x9gknd 5761 23 Hb)/hematocrit Hb)/hematocrit NNP cord-010119-t1x9gknd 5761 24 ( ( -LRB- cord-010119-t1x9gknd 5761 25 Hct Hct NNP cord-010119-t1x9gknd 5761 26 ) ) -RRB- cord-010119-t1x9gknd 5761 27 of of IN cord-010119-t1x9gknd 5761 28 1.6 1.6 CD cord-010119-t1x9gknd 5761 29 g g NN cord-010119-t1x9gknd 5761 30 / / SYM cord-010119-t1x9gknd 5761 31 dL/4.9 dl/4.9 CD cord-010119-t1x9gknd 5761 32 % % NN cord-010119-t1x9gknd 5761 33 . . . cord-010119-t1x9gknd 5762 1 WBC WBC NNP cord-010119-t1x9gknd 5762 2 counts count VBZ cord-010119-t1x9gknd 5762 3 ( ( -LRB- cord-010119-t1x9gknd 5762 4 19 19 CD cord-010119-t1x9gknd 5762 5 x x SYM cord-010119-t1x9gknd 5762 6 10 10 CD cord-010119-t1x9gknd 5762 7 9 9 CD cord-010119-t1x9gknd 5762 8 /L /L . cord-010119-t1x9gknd 5762 9 ) ) -RRB- cord-010119-t1x9gknd 5762 10 were be VBD cord-010119-t1x9gknd 5762 11 mildly mildly RB cord-010119-t1x9gknd 5762 12 elevated elevated JJ cord-010119-t1x9gknd 5762 13 and and CC cord-010119-t1x9gknd 5762 14 platelet platelet NN cord-010119-t1x9gknd 5762 15 counts count NNS cord-010119-t1x9gknd 5762 16 ( ( -LRB- cord-010119-t1x9gknd 5762 17 410 410 CD cord-010119-t1x9gknd 5762 18 x x SYM cord-010119-t1x9gknd 5762 19 10 10 CD cord-010119-t1x9gknd 5762 20 9 9 CD cord-010119-t1x9gknd 5762 21 /L /L . cord-010119-t1x9gknd 5762 22 ) ) -RRB- cord-010119-t1x9gknd 5762 23 were be VBD cord-010119-t1x9gknd 5762 24 within within IN cord-010119-t1x9gknd 5762 25 normal normal JJ cord-010119-t1x9gknd 5762 26 limits limit NNS cord-010119-t1x9gknd 5762 27 . . . cord-010119-t1x9gknd 5763 1 Her -PRON- PRP$ cord-010119-t1x9gknd 5763 2 history history NN cord-010119-t1x9gknd 5763 3 was be VBD cord-010119-t1x9gknd 5763 4 notable notable JJ cord-010119-t1x9gknd 5763 5 for for IN cord-010119-t1x9gknd 5763 6 upper upper JJ cord-010119-t1x9gknd 5763 7 respiratory respiratory JJ cord-010119-t1x9gknd 5763 8 tract tract NN cord-010119-t1x9gknd 5763 9 infection infection NN cord-010119-t1x9gknd 5763 10 6 6 CD cord-010119-t1x9gknd 5763 11 days day NNS cord-010119-t1x9gknd 5763 12 prior prior RB cord-010119-t1x9gknd 5763 13 to to IN cord-010119-t1x9gknd 5763 14 the the DT cord-010119-t1x9gknd 5763 15 onset onset NN cord-010119-t1x9gknd 5763 16 of of IN cord-010119-t1x9gknd 5763 17 anemia anemia NN cord-010119-t1x9gknd 5763 18 . . . cord-010119-t1x9gknd 5764 1 Laboratory laboratory NN cord-010119-t1x9gknd 5764 2 studies study NNS cord-010119-t1x9gknd 5764 3 on on IN cord-010119-t1x9gknd 5764 4 admission admission NN cord-010119-t1x9gknd 5764 5 showed show VBD cord-010119-t1x9gknd 5764 6 hyperbilirubinemia hyperbilirubinemia NNP cord-010119-t1x9gknd 5764 7 ( ( -LRB- cord-010119-t1x9gknd 5764 8 total total JJ cord-010119-t1x9gknd 5764 9 7.1 7.1 CD cord-010119-t1x9gknd 5764 10 mg mg NNP cord-010119-t1x9gknd 5764 11 / / SYM cord-010119-t1x9gknd 5764 12 dL dl NN cord-010119-t1x9gknd 5764 13 , , , cord-010119-t1x9gknd 5764 14 direct direct JJ cord-010119-t1x9gknd 5764 15 1.4 1.4 CD cord-010119-t1x9gknd 5764 16 mg mg NNP cord-010119-t1x9gknd 5764 17 / / SYM cord-010119-t1x9gknd 5764 18 dL dl NN cord-010119-t1x9gknd 5764 19 ) ) -RRB- cord-010119-t1x9gknd 5764 20 , , , cord-010119-t1x9gknd 5764 21 normal normal JJ cord-010119-t1x9gknd 5764 22 LDH LDH NNP cord-010119-t1x9gknd 5764 23 ( ( -LRB- cord-010119-t1x9gknd 5764 24 318 318 CD cord-010119-t1x9gknd 5764 25 U U NNP cord-010119-t1x9gknd 5764 26 / / SYM cord-010119-t1x9gknd 5764 27 L L NNP cord-010119-t1x9gknd 5764 28 ) ) -RRB- cord-010119-t1x9gknd 5764 29 , , , cord-010119-t1x9gknd 5764 30 and and CC cord-010119-t1x9gknd 5764 31 undetectable undetectable JJ cord-010119-t1x9gknd 5764 32 haptoglobin haptoglobin NN cord-010119-t1x9gknd 5764 33 ( ( -LRB- cord-010119-t1x9gknd 5764 34 < < NNP cord-010119-t1x9gknd 5764 35 7 7 CD cord-010119-t1x9gknd 5764 36 mg mg NNP cord-010119-t1x9gknd 5764 37 / / SYM cord-010119-t1x9gknd 5764 38 dL dl NN cord-010119-t1x9gknd 5764 39 ) ) -RRB- cord-010119-t1x9gknd 5764 40 indicative indicative JJ cord-010119-t1x9gknd 5764 41 of of IN cord-010119-t1x9gknd 5764 42 ongoing ongoing JJ cord-010119-t1x9gknd 5764 43 hemolysis hemolysis NN cord-010119-t1x9gknd 5764 44 . . . cord-010119-t1x9gknd 5765 1 Clinical clinical JJ cord-010119-t1x9gknd 5765 2 symptoms symptom NNS cord-010119-t1x9gknd 5765 3 included include VBD cord-010119-t1x9gknd 5765 4 diffuse diffuse JJ cord-010119-t1x9gknd 5765 5 jaundice jaundice NN cord-010119-t1x9gknd 5765 6 , , , cord-010119-t1x9gknd 5765 7 hemoglobinuria hemoglobinuria NNP cord-010119-t1x9gknd 5765 8 , , , cord-010119-t1x9gknd 5765 9 lethargy lethargy NN cord-010119-t1x9gknd 5765 10 , , , cord-010119-t1x9gknd 5765 11 and and CC cord-010119-t1x9gknd 5765 12 emesis emesis NN cord-010119-t1x9gknd 5765 13 . . . cord-010119-t1x9gknd 5766 1 She -PRON- PRP cord-010119-t1x9gknd 5766 2 was be VBD cord-010119-t1x9gknd 5766 3 admitted admit VBN cord-010119-t1x9gknd 5766 4 to to IN cord-010119-t1x9gknd 5766 5 the the DT cord-010119-t1x9gknd 5766 6 pediatric pediatric JJ cord-010119-t1x9gknd 5766 7 intensive intensive JJ cord-010119-t1x9gknd 5766 8 care care NN cord-010119-t1x9gknd 5766 9 unit unit NN cord-010119-t1x9gknd 5766 10 for for IN cord-010119-t1x9gknd 5766 11 further further JJ cord-010119-t1x9gknd 5766 12 management management NN cord-010119-t1x9gknd 5766 13 , , , cord-010119-t1x9gknd 5766 14 including include VBG cord-010119-t1x9gknd 5766 15 right right JJ cord-010119-t1x9gknd 5766 16 internal internal JJ cord-010119-t1x9gknd 5766 17 jugular jugular NN cord-010119-t1x9gknd 5766 18 central central JJ cord-010119-t1x9gknd 5766 19 venous venous JJ cord-010119-t1x9gknd 5766 20 catheter catheter NN cord-010119-t1x9gknd 5766 21 placement placement NN cord-010119-t1x9gknd 5766 22 due due IN cord-010119-t1x9gknd 5766 23 to to IN cord-010119-t1x9gknd 5766 24 poor poor JJ cord-010119-t1x9gknd 5766 25 peripheral peripheral JJ cord-010119-t1x9gknd 5766 26 vascular vascular JJ cord-010119-t1x9gknd 5766 27 access access NN cord-010119-t1x9gknd 5766 28 . . . cord-010119-t1x9gknd 5767 1 The the DT cord-010119-t1x9gknd 5767 2 patient patient NN cord-010119-t1x9gknd 5767 3 's 's POS cord-010119-t1x9gknd 5767 4 blood blood NN cord-010119-t1x9gknd 5767 5 group group NN cord-010119-t1x9gknd 5767 6 was be VBD cord-010119-t1x9gknd 5767 7 O o UH cord-010119-t1x9gknd 5767 8 , , , cord-010119-t1x9gknd 5767 9 Rh Rh NNP cord-010119-t1x9gknd 5767 10 ( ( -LRB- cord-010119-t1x9gknd 5767 11 D)-negative D)-negative NNP cord-010119-t1x9gknd 5767 12 with with IN cord-010119-t1x9gknd 5767 13 a a DT cord-010119-t1x9gknd 5767 14 positive positive JJ cord-010119-t1x9gknd 5767 15 antibody antibody NN cord-010119-t1x9gknd 5767 16 screen screen NN cord-010119-t1x9gknd 5767 17 and and CC cord-010119-t1x9gknd 5767 18 panel panel NN cord-010119-t1x9gknd 5767 19 demonstrating demonstrate VBG cord-010119-t1x9gknd 5767 20 a a DT cord-010119-t1x9gknd 5767 21 strong strong JJ cord-010119-t1x9gknd 5767 22 panagglutinin panagglutinin NNS cord-010119-t1x9gknd 5767 23 ( ( -LRB- cord-010119-t1x9gknd 5767 24 3 3 CD cord-010119-t1x9gknd 5767 25 - - SYM cord-010119-t1x9gknd 5767 26 41 41 CD cord-010119-t1x9gknd 5767 27 reactivity reactivity NN cord-010119-t1x9gknd 5767 28 ) ) -RRB- cord-010119-t1x9gknd 5767 29 with with IN cord-010119-t1x9gknd 5767 30 positive positive JJ cord-010119-t1x9gknd 5767 31 autocontrol autocontrol NN cord-010119-t1x9gknd 5767 32 . . . cord-010119-t1x9gknd 5768 1 DAT DAT NNP cord-010119-t1x9gknd 5768 2 was be VBD cord-010119-t1x9gknd 5768 3 41 41 CD cord-010119-t1x9gknd 5768 4 positive positive JJ cord-010119-t1x9gknd 5768 5 for for IN cord-010119-t1x9gknd 5768 6 anti anti JJ cord-010119-t1x9gknd 5768 7 - - JJ cord-010119-t1x9gknd 5768 8 IgG igg JJ cord-010119-t1x9gknd 5768 9 and and CC cord-010119-t1x9gknd 5768 10 negative negative JJ cord-010119-t1x9gknd 5768 11 for for IN cord-010119-t1x9gknd 5768 12 C3 C3 NNP cord-010119-t1x9gknd 5768 13 despite despite IN cord-010119-t1x9gknd 5768 14 a a DT cord-010119-t1x9gknd 5768 15 positive positive JJ cord-010119-t1x9gknd 5768 16 cold cold JJ cord-010119-t1x9gknd 5768 17 antibody antibody NN cord-010119-t1x9gknd 5768 18 screen screen NN cord-010119-t1x9gknd 5768 19 . . . cord-010119-t1x9gknd 5769 1 The the DT cord-010119-t1x9gknd 5769 2 patient patient NN cord-010119-t1x9gknd 5769 3 weighed weigh VBD cord-010119-t1x9gknd 5769 4 6.9 6.9 CD cord-010119-t1x9gknd 5769 5 kg kg NNS cord-010119-t1x9gknd 5769 6 with with IN cord-010119-t1x9gknd 5769 7 an an DT cord-010119-t1x9gknd 5769 8 estimated estimate VBN cord-010119-t1x9gknd 5769 9 total total JJ cord-010119-t1x9gknd 5769 10 blood blood NN cord-010119-t1x9gknd 5769 11 volume volume NN cord-010119-t1x9gknd 5769 12 of of IN cord-010119-t1x9gknd 5769 13 620 620 CD cord-010119-t1x9gknd 5770 1 mL. mL. NNP cord-010119-t1x9gknd 5770 2 She -PRON- PRP cord-010119-t1x9gknd 5770 3 initially initially RB cord-010119-t1x9gknd 5770 4 received receive VBD cord-010119-t1x9gknd 5770 5 simple simple JJ cord-010119-t1x9gknd 5770 6 transfusions transfusion NNS cord-010119-t1x9gknd 5770 7 totaling total VBG cord-010119-t1x9gknd 5770 8 20 20 CD cord-010119-t1x9gknd 5770 9 mL ml NN cord-010119-t1x9gknd 5770 10 / / SYM cord-010119-t1x9gknd 5770 11 kg kg NNS cord-010119-t1x9gknd 5770 12 of of IN cord-010119-t1x9gknd 5770 13 least least JJS cord-010119-t1x9gknd 5770 14 incompatible incompatible JJ cord-010119-t1x9gknd 5770 15 group group NN cord-010119-t1x9gknd 5770 16 O o NN cord-010119-t1x9gknd 5770 17 Rh(D)-negative Rh(D)-negative JJR cord-010119-t1x9gknd 5770 18 RBCs rbc NNS cord-010119-t1x9gknd 5770 19 with with IN cord-010119-t1x9gknd 5770 20 no no DT cord-010119-t1x9gknd 5770 21 incremental incremental JJ cord-010119-t1x9gknd 5770 22 response response NN cord-010119-t1x9gknd 5770 23 . . . cord-010119-t1x9gknd 5771 1 Manual Manual NNP cord-010119-t1x9gknd 5771 2 WBEX WBEX NNP cord-010119-t1x9gknd 5771 3 was be VBD cord-010119-t1x9gknd 5771 4 then then RB cord-010119-t1x9gknd 5771 5 performed perform VBN cord-010119-t1x9gknd 5771 6 with with IN cord-010119-t1x9gknd 5771 7 463 463 CD cord-010119-t1x9gknd 5771 8 mL mL NNS cord-010119-t1x9gknd 5771 9 of of IN cord-010119-t1x9gknd 5771 10 reconstituted reconstitute VBN cord-010119-t1x9gknd 5771 11 whole whole JJ cord-010119-t1x9gknd 5771 12 blood blood NN cord-010119-t1x9gknd 5771 13 consisting consist VBG cord-010119-t1x9gknd 5771 14 of of IN cord-010119-t1x9gknd 5771 15 O o NN cord-010119-t1x9gknd 5771 16 , , , cord-010119-t1x9gknd 5771 17 Rh(D)-negative rh(d)-negative JJ cord-010119-t1x9gknd 5771 18 RBCs rbc NNS cord-010119-t1x9gknd 5771 19 and and CC cord-010119-t1x9gknd 5771 20 AB AB NNP cord-010119-t1x9gknd 5771 21 fresh fresh JJ cord-010119-t1x9gknd 5771 22 frozen frozen JJ cord-010119-t1x9gknd 5771 23 plasma plasma NN cord-010119-t1x9gknd 5771 24 ( ( -LRB- cord-010119-t1x9gknd 5771 25 FFP FFP NNP cord-010119-t1x9gknd 5771 26 ) ) -RRB- cord-010119-t1x9gknd 5771 27 to to IN cord-010119-t1x9gknd 5771 28 an an DT cord-010119-t1x9gknd 5771 29 Hct Hct NNP cord-010119-t1x9gknd 5771 30 of of IN cord-010119-t1x9gknd 5771 31 40 40 CD cord-010119-t1x9gknd 5771 32 % % NN cord-010119-t1x9gknd 5771 33 , , , cord-010119-t1x9gknd 5771 34 utilizing utilize VBG cord-010119-t1x9gknd 5771 35 the the DT cord-010119-t1x9gknd 5771 36 central central JJ cord-010119-t1x9gknd 5771 37 venous venous JJ cord-010119-t1x9gknd 5771 38 catheter catheter NN cord-010119-t1x9gknd 5771 39 . . . cord-010119-t1x9gknd 5772 1 No no DT cord-010119-t1x9gknd 5772 2 adverse adverse JJ cord-010119-t1x9gknd 5772 3 events event NNS cord-010119-t1x9gknd 5772 4 took take VBD cord-010119-t1x9gknd 5772 5 place place NN cord-010119-t1x9gknd 5772 6 over over IN cord-010119-t1x9gknd 5772 7 the the DT cord-010119-t1x9gknd 5772 8 course course NN cord-010119-t1x9gknd 5772 9 of of IN cord-010119-t1x9gknd 5772 10 the the DT cord-010119-t1x9gknd 5772 11 2 2 CD cord-010119-t1x9gknd 5772 12 hour hour NN cord-010119-t1x9gknd 5772 13 exchange exchange NN cord-010119-t1x9gknd 5772 14 . . . cord-010119-t1x9gknd 5773 1 Her -PRON- PRP$ cord-010119-t1x9gknd 5773 2 one one CD cord-010119-t1x9gknd 5773 3 hour hour NN cord-010119-t1x9gknd 5773 4 post post JJ cord-010119-t1x9gknd 5773 5 - - JJ cord-010119-t1x9gknd 5773 6 exchange exchange NN cord-010119-t1x9gknd 5773 7 Hb Hb NNP cord-010119-t1x9gknd 5773 8 was be VBD cord-010119-t1x9gknd 5773 9 9.5 9.5 CD cord-010119-t1x9gknd 5773 10 g/ g/ JJ cord-010119-t1x9gknd 5773 11 dL dl NN cord-010119-t1x9gknd 5773 12 and and CC cord-010119-t1x9gknd 5773 13 a a DT cord-010119-t1x9gknd 5773 14 subsequent subsequent JJ cord-010119-t1x9gknd 5773 15 antibody antibody NN cord-010119-t1x9gknd 5773 16 screen screen NN cord-010119-t1x9gknd 5773 17 demonstrated demonstrate VBD cord-010119-t1x9gknd 5773 18 reduced reduced JJ cord-010119-t1x9gknd 5773 19 intensity intensity NN cord-010119-t1x9gknd 5773 20 of of IN cord-010119-t1x9gknd 5773 21 the the DT cord-010119-t1x9gknd 5773 22 panagglutinin panagglutinin NNS cord-010119-t1x9gknd 5773 23 ( ( -LRB- cord-010119-t1x9gknd 5773 24 21 21 CD cord-010119-t1x9gknd 5773 25 ) ) -RRB- cord-010119-t1x9gknd 5773 26 . . . cord-010119-t1x9gknd 5774 1 After after IN cord-010119-t1x9gknd 5774 2 initiation initiation NN cord-010119-t1x9gknd 5774 3 of of IN cord-010119-t1x9gknd 5774 4 steroid steroid NN cord-010119-t1x9gknd 5774 5 therapy therapy NN cord-010119-t1x9gknd 5774 6 ( ( -LRB- cord-010119-t1x9gknd 5774 7 methylprednisolone methylprednisolone NNP cord-010119-t1x9gknd 5774 8 , , , cord-010119-t1x9gknd 5774 9 2 2 CD cord-010119-t1x9gknd 5774 10 mg mg NNP cord-010119-t1x9gknd 5774 11 / / SYM cord-010119-t1x9gknd 5774 12 kg kg NNP cord-010119-t1x9gknd 5774 13 / / SYM cord-010119-t1x9gknd 5774 14 day day NN cord-010119-t1x9gknd 5774 15 ) ) -RRB- cord-010119-t1x9gknd 5774 16 , , , cord-010119-t1x9gknd 5774 17 she -PRON- PRP cord-010119-t1x9gknd 5774 18 continued continue VBD cord-010119-t1x9gknd 5774 19 to to TO cord-010119-t1x9gknd 5774 20 improve improve VB cord-010119-t1x9gknd 5774 21 clinically clinically RB cord-010119-t1x9gknd 5774 22 . . . cord-010119-t1x9gknd 5775 1 One one CD cord-010119-t1x9gknd 5775 2 week week NN cord-010119-t1x9gknd 5775 3 later later RB cord-010119-t1x9gknd 5775 4 , , , cord-010119-t1x9gknd 5775 5 the the DT cord-010119-t1x9gknd 5775 6 patient patient NN cord-010119-t1x9gknd 5775 7 was be VBD cord-010119-t1x9gknd 5775 8 discharged discharge VBN cord-010119-t1x9gknd 5775 9 home home RB cord-010119-t1x9gknd 5775 10 with with IN cord-010119-t1x9gknd 5775 11 a a DT cord-010119-t1x9gknd 5775 12 Hb Hb NNP cord-010119-t1x9gknd 5775 13 of of IN cord-010119-t1x9gknd 5775 14 11 11 CD cord-010119-t1x9gknd 5775 15 g g NN cord-010119-t1x9gknd 5775 16 / / SYM cord-010119-t1x9gknd 5775 17 dL. dl. NN cord-010119-t1x9gknd 5776 1 One one CD cord-010119-t1x9gknd 5776 2 month month NN cord-010119-t1x9gknd 5776 3 later later RB cord-010119-t1x9gknd 5776 4 , , , cord-010119-t1x9gknd 5776 5 she -PRON- PRP cord-010119-t1x9gknd 5776 6 experienced experience VBD cord-010119-t1x9gknd 5776 7 recurrent recurrent JJ cord-010119-t1x9gknd 5776 8 hemolysis hemolysis NN cord-010119-t1x9gknd 5776 9 requiring require VBG cord-010119-t1x9gknd 5776 10 re re NN cord-010119-t1x9gknd 5776 11 - - NN cord-010119-t1x9gknd 5776 12 hospitalization hospitalization NN cord-010119-t1x9gknd 5776 13 , , , cord-010119-t1x9gknd 5776 14 at at IN cord-010119-t1x9gknd 5776 15 which which WDT cord-010119-t1x9gknd 5776 16 time time NN cord-010119-t1x9gknd 5776 17 she -PRON- PRP cord-010119-t1x9gknd 5776 18 had have VBD cord-010119-t1x9gknd 5776 19 normal normal JJ cord-010119-t1x9gknd 5776 20 IgM IgM NNP cord-010119-t1x9gknd 5776 21 and and CC cord-010119-t1x9gknd 5776 22 IgA IgA NNP cord-010119-t1x9gknd 5776 23 levels level NNS cord-010119-t1x9gknd 5776 24 with with IN cord-010119-t1x9gknd 5776 25 markedly markedly RB cord-010119-t1x9gknd 5776 26 elevated elevate VBN cord-010119-t1x9gknd 5776 27 IgG igg NN cord-010119-t1x9gknd 5776 28 levels level NNS cord-010119-t1x9gknd 5776 29 ( ( -LRB- cord-010119-t1x9gknd 5776 30 3168 3168 CD cord-010119-t1x9gknd 5776 31 mg mg NNP cord-010119-t1x9gknd 5776 32 / / SYM cord-010119-t1x9gknd 5776 33 dL dl NN cord-010119-t1x9gknd 5776 34 ) ) -RRB- cord-010119-t1x9gknd 5776 35 . . . cord-010119-t1x9gknd 5777 1 At at IN cord-010119-t1x9gknd 5777 2 a a DT cord-010119-t1x9gknd 5777 3 subsequent subsequent JJ cord-010119-t1x9gknd 5777 4 follow follow NN cord-010119-t1x9gknd 5777 5 - - HYPH cord-010119-t1x9gknd 5777 6 up up NN cord-010119-t1x9gknd 5777 7 visit visit NN cord-010119-t1x9gknd 5777 8 3 3 CD cord-010119-t1x9gknd 5777 9 months month NNS cord-010119-t1x9gknd 5777 10 after after IN cord-010119-t1x9gknd 5777 11 her -PRON- PRP$ cord-010119-t1x9gknd 5777 12 initial initial JJ cord-010119-t1x9gknd 5777 13 presentation presentation NN cord-010119-t1x9gknd 5777 14 , , , cord-010119-t1x9gknd 5777 15 her -PRON- PRP$ cord-010119-t1x9gknd 5777 16 anemia anemia NN cord-010119-t1x9gknd 5777 17 had have VBD cord-010119-t1x9gknd 5777 18 resolved resolve VBN cord-010119-t1x9gknd 5777 19 and and CC cord-010119-t1x9gknd 5777 20 she -PRON- PRP cord-010119-t1x9gknd 5777 21 had have VBD cord-010119-t1x9gknd 5777 22 been be VBN cord-010119-t1x9gknd 5777 23 completely completely RB cord-010119-t1x9gknd 5777 24 weaned wean VBN cord-010119-t1x9gknd 5777 25 off off RP cord-010119-t1x9gknd 5777 26 steroids steroid NNS cord-010119-t1x9gknd 5777 27 . . . cord-010119-t1x9gknd 5778 1 Conclusion conclusion NN cord-010119-t1x9gknd 5778 2 : : : cord-010119-t1x9gknd 5778 3 We -PRON- PRP cord-010119-t1x9gknd 5778 4 demonstrate demonstrate VBP cord-010119-t1x9gknd 5778 5 a a DT cord-010119-t1x9gknd 5778 6 case case NN cord-010119-t1x9gknd 5778 7 of of IN cord-010119-t1x9gknd 5778 8 severe severe JJ cord-010119-t1x9gknd 5778 9 neonatal neonatal JJ cord-010119-t1x9gknd 5778 10 AIHA AIHA NNP cord-010119-t1x9gknd 5778 11 successfully successfully RB cord-010119-t1x9gknd 5778 12 treated treat VBN cord-010119-t1x9gknd 5778 13 with with IN cord-010119-t1x9gknd 5778 14 manual manual JJ cord-010119-t1x9gknd 5778 15 WBEX WBEX NNP cord-010119-t1x9gknd 5778 16 . . . cord-010119-t1x9gknd 5779 1 The the DT cord-010119-t1x9gknd 5779 2 main main JJ cord-010119-t1x9gknd 5779 3 advantages advantage NNS cord-010119-t1x9gknd 5779 4 of of IN cord-010119-t1x9gknd 5779 5 WBEX WBEX NNP cord-010119-t1x9gknd 5779 6 include include VBP cord-010119-t1x9gknd 5779 7 removal removal NN cord-010119-t1x9gknd 5779 8 of of IN cord-010119-t1x9gknd 5779 9 both both DT cord-010119-t1x9gknd 5779 10 autologous autologous JJ cord-010119-t1x9gknd 5779 11 RBCs rbc NNS cord-010119-t1x9gknd 5779 12 and and CC cord-010119-t1x9gknd 5779 13 plasma plasma NN cord-010119-t1x9gknd 5779 14 as as RB cord-010119-t1x9gknd 5779 15 well well RB cord-010119-t1x9gknd 5779 16 as as IN cord-010119-t1x9gknd 5779 17 infusion infusion NN cord-010119-t1x9gknd 5779 18 of of IN cord-010119-t1x9gknd 5779 19 allogeneic allogeneic NN cord-010119-t1x9gknd 5779 20 RBCs rbc NNS cord-010119-t1x9gknd 5779 21 . . . cord-010119-t1x9gknd 5780 1 In in IN cord-010119-t1x9gknd 5780 2 this this DT cord-010119-t1x9gknd 5780 3 case case NN cord-010119-t1x9gknd 5780 4 , , , cord-010119-t1x9gknd 5780 5 manual manual JJ cord-010119-t1x9gknd 5780 6 exchange exchange NN cord-010119-t1x9gknd 5780 7 transfusion transfusion NN cord-010119-t1x9gknd 5780 8 avoided avoid VBD cord-010119-t1x9gknd 5780 9 the the DT cord-010119-t1x9gknd 5780 10 need need NN cord-010119-t1x9gknd 5780 11 for for IN cord-010119-t1x9gknd 5780 12 an an DT cord-010119-t1x9gknd 5780 13 automated automate VBN cord-010119-t1x9gknd 5780 14 apheresis apheresis NN cord-010119-t1x9gknd 5780 15 procedure procedure NN cord-010119-t1x9gknd 5780 16 requiring require VBG cord-010119-t1x9gknd 5780 17 citrate citrate NN cord-010119-t1x9gknd 5780 18 anticoagulation anticoagulation NN cord-010119-t1x9gknd 5780 19 . . . cord-010119-t1x9gknd 5781 1 In in IN cord-010119-t1x9gknd 5781 2 summary summary NN cord-010119-t1x9gknd 5781 3 , , , cord-010119-t1x9gknd 5781 4 manual manual JJ cord-010119-t1x9gknd 5781 5 WBEX WBEX NNP cord-010119-t1x9gknd 5781 6 is be VBZ cord-010119-t1x9gknd 5781 7 a a DT cord-010119-t1x9gknd 5781 8 potentially potentially RB cord-010119-t1x9gknd 5781 9 safe safe JJ cord-010119-t1x9gknd 5781 10 procedure procedure NN cord-010119-t1x9gknd 5781 11 that that WDT cord-010119-t1x9gknd 5781 12 may may MD cord-010119-t1x9gknd 5781 13 be be VB cord-010119-t1x9gknd 5781 14 performed perform VBN cord-010119-t1x9gknd 5781 15 in in IN cord-010119-t1x9gknd 5781 16 young young JJ cord-010119-t1x9gknd 5781 17 children child NNS cord-010119-t1x9gknd 5781 18 with with IN cord-010119-t1x9gknd 5781 19 severe severe JJ cord-010119-t1x9gknd 5781 20 AIHA AIHA NNP cord-010119-t1x9gknd 5781 21 . . . cord-010119-t1x9gknd 5782 1 ABSTRACT abstract JJ cord-010119-t1x9gknd 5782 2 operating operating NN cord-010119-t1x9gknd 5782 3 room room NN cord-010119-t1x9gknd 5782 4 , , , cord-010119-t1x9gknd 5782 5 each each DT cord-010119-t1x9gknd 5782 6 experienced experience VBN cord-010119-t1x9gknd 5782 7 blood blood NN cord-010119-t1x9gknd 5782 8 - - HYPH cord-010119-t1x9gknd 5782 9 colored color VBN cord-010119-t1x9gknd 5782 10 urine urine NN cord-010119-t1x9gknd 5782 11 , , , cord-010119-t1x9gknd 5782 12 laboratory laboratory NN cord-010119-t1x9gknd 5782 13 evidence evidence NN cord-010119-t1x9gknd 5782 14 of of IN cord-010119-t1x9gknd 5782 15 hemolysis hemolysis NN cord-010119-t1x9gknd 5782 16 , , , cord-010119-t1x9gknd 5782 17 and and CC cord-010119-t1x9gknd 5782 18 acute acute JJ cord-010119-t1x9gknd 5782 19 kidney kidney NN cord-010119-t1x9gknd 5782 20 injury injury NN cord-010119-t1x9gknd 5782 21 . . . cord-010119-t1x9gknd 5783 1 Clerical clerical JJ cord-010119-t1x9gknd 5783 2 and and CC cord-010119-t1x9gknd 5783 3 serologic serologic JJ cord-010119-t1x9gknd 5783 4 investigations investigation NNS cord-010119-t1x9gknd 5783 5 revealed reveal VBD cord-010119-t1x9gknd 5783 6 no no DT cord-010119-t1x9gknd 5783 7 cause cause NN cord-010119-t1x9gknd 5783 8 for for IN cord-010119-t1x9gknd 5783 9 hemolysis hemolysis NN cord-010119-t1x9gknd 5783 10 . . . cord-010119-t1x9gknd 5784 1 Mechanical mechanical JJ cord-010119-t1x9gknd 5784 2 hemolysis hemolysis NN cord-010119-t1x9gknd 5784 3 from from IN cord-010119-t1x9gknd 5784 4 transfusion transfusion NN cord-010119-t1x9gknd 5784 5 rate rate NN cord-010119-t1x9gknd 5784 6 , , , cord-010119-t1x9gknd 5784 7 catheter catheter NN cord-010119-t1x9gknd 5784 8 gauge gauge NN cord-010119-t1x9gknd 5784 9 , , , cord-010119-t1x9gknd 5784 10 or or CC cord-010119-t1x9gknd 5784 11 a a DT cord-010119-t1x9gknd 5784 12 recently recently RB cord-010119-t1x9gknd 5784 13 introduced introduce VBN cord-010119-t1x9gknd 5784 14 one one CD cord-010119-t1x9gknd 5784 15 - - HYPH cord-010119-t1x9gknd 5784 16 way way NN cord-010119-t1x9gknd 5784 17 valve valve NN cord-010119-t1x9gknd 5784 18 was be VBD cord-010119-t1x9gknd 5784 19 considered consider VBN cord-010119-t1x9gknd 5784 20 . . . cord-010119-t1x9gknd 5785 1 Study Study NNP cord-010119-t1x9gknd 5785 2 Design Design NNP cord-010119-t1x9gknd 5785 3 / / SYM cord-010119-t1x9gknd 5785 4 Methods method NNS cord-010119-t1x9gknd 5785 5 : : : cord-010119-t1x9gknd 5785 6 In in IN cord-010119-t1x9gknd 5785 7 vitro vitro FW cord-010119-t1x9gknd 5785 8 simulated simulate VBN cord-010119-t1x9gknd 5785 9 transfusions transfusion NNS cord-010119-t1x9gknd 5785 10 were be VBD cord-010119-t1x9gknd 5785 11 performed perform VBN cord-010119-t1x9gknd 5785 12 via via IN cord-010119-t1x9gknd 5785 13 syringe syringe NN cord-010119-t1x9gknd 5785 14 . . . cord-010119-t1x9gknd 5786 1 Measurements measurement NNS cord-010119-t1x9gknd 5786 2 included include VBD cord-010119-t1x9gknd 5786 3 hematocrit hematocrit NN cord-010119-t1x9gknd 5786 4 ( ( -LRB- cord-010119-t1x9gknd 5786 5 Hct Hct NNP cord-010119-t1x9gknd 5786 6 ) ) -RRB- cord-010119-t1x9gknd 5786 7 , , , cord-010119-t1x9gknd 5786 8 free free JJ cord-010119-t1x9gknd 5786 9 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5786 10 , , , cord-010119-t1x9gknd 5786 11 and and CC cord-010119-t1x9gknd 5786 12 visual visual JJ cord-010119-t1x9gknd 5786 13 hemolysis hemolysis NN cord-010119-t1x9gknd 5786 14 index index NN cord-010119-t1x9gknd 5786 15 . . . cord-010119-t1x9gknd 5787 1 Washed washed JJ cord-010119-t1x9gknd 5787 2 and and CC cord-010119-t1x9gknd 5787 3 unwashed unwashed JJ cord-010119-t1x9gknd 5787 4 red red JJ cord-010119-t1x9gknd 5787 5 blood blood NN cord-010119-t1x9gknd 5787 6 cells cell NNS cord-010119-t1x9gknd 5787 7 ( ( -LRB- cord-010119-t1x9gknd 5787 8 RBCs rbc NNS cord-010119-t1x9gknd 5787 9 ) ) -RRB- cord-010119-t1x9gknd 5787 10 were be VBD cord-010119-t1x9gknd 5787 11 tested test VBN cord-010119-t1x9gknd 5787 12 with with IN cord-010119-t1x9gknd 5787 13 or or CC cord-010119-t1x9gknd 5787 14 without without IN cord-010119-t1x9gknd 5787 15 a a DT cord-010119-t1x9gknd 5787 16 one one CD cord-010119-t1x9gknd 5787 17 - - HYPH cord-010119-t1x9gknd 5787 18 way way NN cord-010119-t1x9gknd 5787 19 valve valve NN cord-010119-t1x9gknd 5787 20 , , , cord-010119-t1x9gknd 5787 21 using use VBG cord-010119-t1x9gknd 5787 22 a a DT cord-010119-t1x9gknd 5787 23 24 24 CD cord-010119-t1x9gknd 5787 24 or or CC cord-010119-t1x9gknd 5787 25 16 16 CD cord-010119-t1x9gknd 5787 26 gauge gauge NN cord-010119-t1x9gknd 5787 27 ( ( -LRB- cord-010119-t1x9gknd 5787 28 G g NN cord-010119-t1x9gknd 5787 29 ) ) -RRB- cord-010119-t1x9gknd 5787 30 intravenous intravenous JJ cord-010119-t1x9gknd 5787 31 ( ( -LRB- cord-010119-t1x9gknd 5787 32 IV IV NNP cord-010119-t1x9gknd 5787 33 ) ) -RRB- cord-010119-t1x9gknd 5787 34 catheter catheter NN cord-010119-t1x9gknd 5787 35 . . . cord-010119-t1x9gknd 5788 1 Each each DT cord-010119-t1x9gknd 5788 2 one one CD cord-010119-t1x9gknd 5788 3 - - HYPH cord-010119-t1x9gknd 5788 4 way way NN cord-010119-t1x9gknd 5788 5 valve valve NN cord-010119-t1x9gknd 5788 6 was be VBD cord-010119-t1x9gknd 5788 7 used use VBN cord-010119-t1x9gknd 5788 8 to to TO cord-010119-t1x9gknd 5788 9 test test VB cord-010119-t1x9gknd 5788 10 three three CD cord-010119-t1x9gknd 5788 11 identical identical JJ cord-010119-t1x9gknd 5788 12 samples sample NNS cord-010119-t1x9gknd 5788 13 . . . cord-010119-t1x9gknd 5789 1 Constant constant JJ cord-010119-t1x9gknd 5789 2 pressure pressure NN cord-010119-t1x9gknd 5789 3 was be VBD cord-010119-t1x9gknd 5789 4 applied apply VBN cord-010119-t1x9gknd 5789 5 manually manually RB cord-010119-t1x9gknd 5789 6 ( ( -LRB- cord-010119-t1x9gknd 5789 7 rapidly rapidly RB cord-010119-t1x9gknd 5789 8 , , , cord-010119-t1x9gknd 5789 9 1.431/-0.49 1.431/-0.49 CD cord-010119-t1x9gknd 5789 10 ml/ ml/ JJ cord-010119-t1x9gknd 5789 11 second second NN cord-010119-t1x9gknd 5789 12 ) ) -RRB- cord-010119-t1x9gknd 5789 13 or or CC cord-010119-t1x9gknd 5789 14 with with IN cord-010119-t1x9gknd 5789 15 a a DT cord-010119-t1x9gknd 5789 16 mechanical mechanical JJ cord-010119-t1x9gknd 5789 17 syringe syringe NN cord-010119-t1x9gknd 5789 18 pump pump NN cord-010119-t1x9gknd 5789 19 ( ( -LRB- cord-010119-t1x9gknd 5789 20 slowly slowly RB cord-010119-t1x9gknd 5789 21 , , , cord-010119-t1x9gknd 5789 22 2 2 CD cord-010119-t1x9gknd 5789 23 ml ml NN cord-010119-t1x9gknd 5789 24 / / SYM cord-010119-t1x9gknd 5789 25 min min NN cord-010119-t1x9gknd 5789 26 ) ) -RRB- cord-010119-t1x9gknd 5789 27 . . . cord-010119-t1x9gknd 5790 1 A a DT cord-010119-t1x9gknd 5790 2 subset subset NN cord-010119-t1x9gknd 5790 3 of of IN cord-010119-t1x9gknd 5790 4 the the DT cord-010119-t1x9gknd 5790 5 manual manual JJ cord-010119-t1x9gknd 5790 6 transfusions transfusion NNS cord-010119-t1x9gknd 5790 7 was be VBD cord-010119-t1x9gknd 5790 8 timed time VBN cord-010119-t1x9gknd 5790 9 . . . cord-010119-t1x9gknd 5791 1 Control control NN cord-010119-t1x9gknd 5791 2 samples sample NNS cord-010119-t1x9gknd 5791 3 for for IN cord-010119-t1x9gknd 5791 4 baseline baseline JJ cord-010119-t1x9gknd 5791 5 measurements measurement NNS cord-010119-t1x9gknd 5791 6 were be VBD cord-010119-t1x9gknd 5791 7 collected collect VBN cord-010119-t1x9gknd 5791 8 by by IN cord-010119-t1x9gknd 5791 9 gravity gravity NN cord-010119-t1x9gknd 5791 10 drip drip NN cord-010119-t1x9gknd 5791 11 , , , cord-010119-t1x9gknd 5791 12 without without IN cord-010119-t1x9gknd 5791 13 passing pass VBG cord-010119-t1x9gknd 5791 14 through through IN cord-010119-t1x9gknd 5791 15 the the DT cord-010119-t1x9gknd 5791 16 one one CD cord-010119-t1x9gknd 5791 17 - - HYPH cord-010119-t1x9gknd 5791 18 way way NN cord-010119-t1x9gknd 5791 19 valve valve NN cord-010119-t1x9gknd 5791 20 or or CC cord-010119-t1x9gknd 5791 21 catheter catheter NN cord-010119-t1x9gknd 5791 22 . . . cord-010119-t1x9gknd 5792 1 Results result NNS cord-010119-t1x9gknd 5792 2 / / SYM cord-010119-t1x9gknd 5792 3 Findings finding NNS cord-010119-t1x9gknd 5792 4 : : : cord-010119-t1x9gknd 5793 1 The the DT cord-010119-t1x9gknd 5793 2 one one CD cord-010119-t1x9gknd 5793 3 - - HYPH cord-010119-t1x9gknd 5793 4 way way NN cord-010119-t1x9gknd 5793 5 valve valve NN cord-010119-t1x9gknd 5793 6 increased increase VBN cord-010119-t1x9gknd 5793 7 hemolysis hemolysis NN cord-010119-t1x9gknd 5793 8 markedly markedly RB cord-010119-t1x9gknd 5793 9 during during IN cord-010119-t1x9gknd 5793 10 rapid rapid JJ cord-010119-t1x9gknd 5793 11 transfusion transfusion NN cord-010119-t1x9gknd 5793 12 using use VBG cord-010119-t1x9gknd 5793 13 both both DT cord-010119-t1x9gknd 5793 14 catheters catheter NNS cord-010119-t1x9gknd 5793 15 as as RB cord-010119-t1x9gknd 5793 16 well well RB cord-010119-t1x9gknd 5793 17 as as IN cord-010119-t1x9gknd 5793 18 both both CC cord-010119-t1x9gknd 5793 19 washed wash VBN cord-010119-t1x9gknd 5793 20 and and CC cord-010119-t1x9gknd 5793 21 unwashed unwashed JJ cord-010119-t1x9gknd 5793 22 RBCs rbc NNS cord-010119-t1x9gknd 5793 23 ( ( -LRB- cord-010119-t1x9gknd 5793 24 see see VB cord-010119-t1x9gknd 5793 25 Table table NN cord-010119-t1x9gknd 5793 26 ) ) -RRB- cord-010119-t1x9gknd 5793 27 . . . cord-010119-t1x9gknd 5794 1 With with IN cord-010119-t1x9gknd 5794 2 the the DT cord-010119-t1x9gknd 5794 3 24 24 CD cord-010119-t1x9gknd 5794 4 G g NN cord-010119-t1x9gknd 5794 5 catheter catheter NN cord-010119-t1x9gknd 5794 6 , , , cord-010119-t1x9gknd 5794 7 the the DT cord-010119-t1x9gknd 5794 8 mean mean JJ cord-010119-t1x9gknd 5794 9 change change NN cord-010119-t1x9gknd 5794 10 in in IN cord-010119-t1x9gknd 5794 11 Hct Hct NNP cord-010119-t1x9gknd 5794 12 was be VBD cord-010119-t1x9gknd 5794 13 -3.531/-0.69 -3.531/-0.69 : cord-010119-t1x9gknd 5794 14 % % NN cord-010119-t1x9gknd 5794 15 with with IN cord-010119-t1x9gknd 5794 16 the the DT cord-010119-t1x9gknd 5794 17 one one CD cord-010119-t1x9gknd 5794 18 - - HYPH cord-010119-t1x9gknd 5794 19 way way NN cord-010119-t1x9gknd 5794 20 valve valve NN cord-010119-t1x9gknd 5794 21 and and CC cord-010119-t1x9gknd 5794 22 0.221/-0.13 0.221/-0.13 CD cord-010119-t1x9gknd 5794 23 % % NN cord-010119-t1x9gknd 5794 24 without without IN cord-010119-t1x9gknd 5794 25 ( ( -LRB- cord-010119-t1x9gknd 5794 26 p<0.00001 p<0.00001 NNP cord-010119-t1x9gknd 5794 27 ) ) -RRB- cord-010119-t1x9gknd 5794 28 . . . cord-010119-t1x9gknd 5795 1 Comparing compare VBG cord-010119-t1x9gknd 5795 2 the the DT cord-010119-t1x9gknd 5795 3 one one CD cord-010119-t1x9gknd 5795 4 - - HYPH cord-010119-t1x9gknd 5795 5 way way NN cord-010119-t1x9gknd 5795 6 valves valve NNS cord-010119-t1x9gknd 5795 7 tested test VBN cord-010119-t1x9gknd 5795 8 , , , cord-010119-t1x9gknd 5795 9 differences difference NNS cord-010119-t1x9gknd 5795 10 in in IN cord-010119-t1x9gknd 5795 11 hemolysis hemolysis NN cord-010119-t1x9gknd 5795 12 were be VBD cord-010119-t1x9gknd 5795 13 observed observe VBN cord-010119-t1x9gknd 5795 14 ( ( -LRB- cord-010119-t1x9gknd 5795 15 change change NN cord-010119-t1x9gknd 5795 16 in in IN cord-010119-t1x9gknd 5795 17 Hct Hct NNP cord-010119-t1x9gknd 5795 18 ; ; , cord-010119-t1x9gknd 5795 19 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 5795 20 ) ) -RRB- cord-010119-t1x9gknd 5795 21 . . . cord-010119-t1x9gknd 5796 1 During during IN cord-010119-t1x9gknd 5796 2 rapid rapid JJ cord-010119-t1x9gknd 5796 3 manual manual JJ cord-010119-t1x9gknd 5796 4 transfusion transfusion NN cord-010119-t1x9gknd 5796 5 with with IN cord-010119-t1x9gknd 5796 6 a a DT cord-010119-t1x9gknd 5796 7 24 24 CD cord-010119-t1x9gknd 5796 8 G g NN cord-010119-t1x9gknd 5796 9 catheter catheter NN cord-010119-t1x9gknd 5796 10 and and CC cord-010119-t1x9gknd 5796 11 unwashed unwashed JJ cord-010119-t1x9gknd 5796 12 RBCs rbc NNS cord-010119-t1x9gknd 5796 13 , , , cord-010119-t1x9gknd 5796 14 hemolysis hemolysis NN cord-010119-t1x9gknd 5796 15 was be VBD cord-010119-t1x9gknd 5796 16 greater great JJR cord-010119-t1x9gknd 5796 17 for for IN cord-010119-t1x9gknd 5796 18 samples sample NNS cord-010119-t1x9gknd 5796 19 that that WDT cord-010119-t1x9gknd 5796 20 took take VBD cord-010119-t1x9gknd 5796 21 longer long RBR cord-010119-t1x9gknd 5796 22 to to TO cord-010119-t1x9gknd 5796 23 transfuse transfuse VB cord-010119-t1x9gknd 5796 24 4.5ml 4.5ml CD cord-010119-t1x9gknd 5796 25 when when WRB cord-010119-t1x9gknd 5796 26 using use VBG cord-010119-t1x9gknd 5796 27 a a DT cord-010119-t1x9gknd 5796 28 one one CD cord-010119-t1x9gknd 5796 29 - - HYPH cord-010119-t1x9gknd 5796 30 way way NN cord-010119-t1x9gknd 5796 31 valve valve NN cord-010119-t1x9gknd 5796 32 ( ( -LRB- cord-010119-t1x9gknd 5796 33 change change NN cord-010119-t1x9gknd 5796 34 in in IN cord-010119-t1x9gknd 5796 35 Hct Hct NNP cord-010119-t1x9gknd 5796 36 versus versus IN cord-010119-t1x9gknd 5796 37 time time NN cord-010119-t1x9gknd 5796 38 : : : cord-010119-t1x9gknd 5796 39 r5 r5 NNP cord-010119-t1x9gknd 5796 40 - - HYPH cord-010119-t1x9gknd 5796 41 0.75 0.75 CD cord-010119-t1x9gknd 5796 42 , , , cord-010119-t1x9gknd 5796 43 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 5796 44 ) ) -RRB- cord-010119-t1x9gknd 5796 45 compared compare VBD cord-010119-t1x9gknd 5796 46 to to IN cord-010119-t1x9gknd 5796 47 a a DT cord-010119-t1x9gknd 5796 48 significantly significantly RB cord-010119-t1x9gknd 5796 49 different different JJ cord-010119-t1x9gknd 5796 50 ( ( -LRB- cord-010119-t1x9gknd 5796 51 p50.0085 p50.0085 VB cord-010119-t1x9gknd 5796 52 ) ) -RRB- cord-010119-t1x9gknd 5796 53 slight slight JJ cord-010119-t1x9gknd 5796 54 increase increase NN cord-010119-t1x9gknd 5796 55 in in IN cord-010119-t1x9gknd 5796 56 hemolysis hemolysis NN cord-010119-t1x9gknd 5796 57 for for IN cord-010119-t1x9gknd 5796 58 samples sample NNS cord-010119-t1x9gknd 5796 59 that that WDT cord-010119-t1x9gknd 5796 60 took take VBD cord-010119-t1x9gknd 5796 61 less less JJR cord-010119-t1x9gknd 5796 62 time time NN cord-010119-t1x9gknd 5796 63 to to TO cord-010119-t1x9gknd 5796 64 transfuse transfuse VB cord-010119-t1x9gknd 5796 65 4.5ml 4.5ml CD cord-010119-t1x9gknd 5796 66 when when WRB cord-010119-t1x9gknd 5796 67 not not RB cord-010119-t1x9gknd 5796 68 using use VBG cord-010119-t1x9gknd 5796 69 a a DT cord-010119-t1x9gknd 5796 70 one one CD cord-010119-t1x9gknd 5796 71 - - HYPH cord-010119-t1x9gknd 5796 72 way way NN cord-010119-t1x9gknd 5796 73 valve valve NN cord-010119-t1x9gknd 5796 74 ( ( -LRB- cord-010119-t1x9gknd 5796 75 change change NN cord-010119-t1x9gknd 5796 76 in in IN cord-010119-t1x9gknd 5796 77 Hct Hct NNP cord-010119-t1x9gknd 5796 78 versus versus IN cord-010119-t1x9gknd 5796 79 time time NN cord-010119-t1x9gknd 5796 80 : : : cord-010119-t1x9gknd 5796 81 r50.58 r50.58 NNP cord-010119-t1x9gknd 5796 82 , , , cord-010119-t1x9gknd 5796 83 p50.23 p50.23 NNP cord-010119-t1x9gknd 5796 84 ) ) -RRB- cord-010119-t1x9gknd 5796 85 . . . cord-010119-t1x9gknd 5797 1 Correlations correlation NNS cord-010119-t1x9gknd 5797 2 between between IN cord-010119-t1x9gknd 5797 3 time time NN cord-010119-t1x9gknd 5797 4 and and CC cord-010119-t1x9gknd 5797 5 hemolysis hemolysis NN cord-010119-t1x9gknd 5797 6 were be VBD cord-010119-t1x9gknd 5797 7 similar similar JJ cord-010119-t1x9gknd 5797 8 , , , cord-010119-t1x9gknd 5797 9 but but CC cord-010119-t1x9gknd 5797 10 insignificant insignificant JJ cord-010119-t1x9gknd 5797 11 using use VBG cord-010119-t1x9gknd 5797 12 24 24 CD cord-010119-t1x9gknd 5797 13 G g NN cord-010119-t1x9gknd 5797 14 with with IN cord-010119-t1x9gknd 5797 15 washed washed JJ cord-010119-t1x9gknd 5797 16 RBCs rbc NNS cord-010119-t1x9gknd 5797 17 and and CC cord-010119-t1x9gknd 5797 18 the the DT cord-010119-t1x9gknd 5797 19 16 16 CD cord-010119-t1x9gknd 5797 20 G G NNP cord-010119-t1x9gknd 5797 21 IV IV NNP cord-010119-t1x9gknd 5797 22 catheter catheter NN cord-010119-t1x9gknd 5797 23 . . . cord-010119-t1x9gknd 5798 1 Conclusion conclusion NN cord-010119-t1x9gknd 5798 2 : : : cord-010119-t1x9gknd 5799 1 Mechanical mechanical JJ cord-010119-t1x9gknd 5799 2 hemolysis hemolysis NN cord-010119-t1x9gknd 5799 3 should should MD cord-010119-t1x9gknd 5799 4 be be VB cord-010119-t1x9gknd 5799 5 considered consider VBN cord-010119-t1x9gknd 5799 6 when when WRB cord-010119-t1x9gknd 5799 7 investigating investigate VBG cord-010119-t1x9gknd 5799 8 possible possible JJ cord-010119-t1x9gknd 5799 9 hemolytic hemolytic JJ cord-010119-t1x9gknd 5799 10 transfusion transfusion NN cord-010119-t1x9gknd 5799 11 reactions reaction NNS cord-010119-t1x9gknd 5799 12 , , , cord-010119-t1x9gknd 5799 13 especially especially RB cord-010119-t1x9gknd 5799 14 with with IN cord-010119-t1x9gknd 5799 15 high high JJ cord-010119-t1x9gknd 5799 16 rates rate NNS cord-010119-t1x9gknd 5799 17 of of IN cord-010119-t1x9gknd 5799 18 transfusion transfusion NN cord-010119-t1x9gknd 5799 19 and and CC cord-010119-t1x9gknd 5799 20 use use NN cord-010119-t1x9gknd 5799 21 of of IN cord-010119-t1x9gknd 5799 22 a a DT cord-010119-t1x9gknd 5799 23 one one CD cord-010119-t1x9gknd 5799 24 - - HYPH cord-010119-t1x9gknd 5799 25 way way NN cord-010119-t1x9gknd 5799 26 valve valve NN cord-010119-t1x9gknd 5799 27 . . . cord-010119-t1x9gknd 5800 1 During during IN cord-010119-t1x9gknd 5800 2 rapid rapid JJ cord-010119-t1x9gknd 5800 3 manual manual JJ cord-010119-t1x9gknd 5800 4 transfusion transfusion NN cord-010119-t1x9gknd 5800 5 with with IN cord-010119-t1x9gknd 5800 6 the the DT cord-010119-t1x9gknd 5800 7 one one CD cord-010119-t1x9gknd 5800 8 - - HYPH cord-010119-t1x9gknd 5800 9 way way NN cord-010119-t1x9gknd 5800 10 valve valve NN cord-010119-t1x9gknd 5800 11 , , , cord-010119-t1x9gknd 5800 12 greater great JJR cord-010119-t1x9gknd 5800 13 resistance resistance NN cord-010119-t1x9gknd 5800 14 was be VBD cord-010119-t1x9gknd 5800 15 associated associate VBN cord-010119-t1x9gknd 5800 16 with with IN cord-010119-t1x9gknd 5800 17 increased increase VBN cord-010119-t1x9gknd 5800 18 hemolysis hemolysis NN cord-010119-t1x9gknd 5800 19 . . . cord-010119-t1x9gknd 5801 1 Background Background NNP cord-010119-t1x9gknd 5801 2 / / SYM cord-010119-t1x9gknd 5801 3 Case Case NNP cord-010119-t1x9gknd 5801 4 Studies Studies NNPS cord-010119-t1x9gknd 5801 5 : : : cord-010119-t1x9gknd 5802 1 Gerbich Gerbich NNP cord-010119-t1x9gknd 5802 2 ( ( -LRB- cord-010119-t1x9gknd 5802 3 Ge Ge NNP cord-010119-t1x9gknd 5802 4 ) ) -RRB- cord-010119-t1x9gknd 5802 5 antigens antigen NNS cord-010119-t1x9gknd 5802 6 expressed express VBN cord-010119-t1x9gknd 5802 7 on on IN cord-010119-t1x9gknd 5802 8 glycophorin glycophorin NNP cord-010119-t1x9gknd 5802 9 C C NNP cord-010119-t1x9gknd 5802 10 are be VBP cord-010119-t1x9gknd 5802 11 present present JJ cord-010119-t1x9gknd 5802 12 in in IN cord-010119-t1x9gknd 5802 13 99.9 99.9 CD cord-010119-t1x9gknd 5802 14 % % NN cord-010119-t1x9gknd 5802 15 of of IN cord-010119-t1x9gknd 5802 16 the the DT cord-010119-t1x9gknd 5802 17 population population NN cord-010119-t1x9gknd 5802 18 . . . cord-010119-t1x9gknd 5803 1 Ge Ge NNP cord-010119-t1x9gknd 5803 2 antibodies antibody NNS cord-010119-t1x9gknd 5803 3 cause cause VBP cord-010119-t1x9gknd 5803 4 delayed delay VBN cord-010119-t1x9gknd 5803 5 hemolytic hemolytic JJ cord-010119-t1x9gknd 5803 6 transfusion transfusion NN cord-010119-t1x9gknd 5803 7 reactions reaction NNS cord-010119-t1x9gknd 5803 8 and and CC cord-010119-t1x9gknd 5803 9 hemolytic hemolytic JJ cord-010119-t1x9gknd 5803 10 disease disease NN cord-010119-t1x9gknd 5803 11 of of IN cord-010119-t1x9gknd 5803 12 the the DT cord-010119-t1x9gknd 5803 13 fetus fetus NN cord-010119-t1x9gknd 5803 14 and and CC cord-010119-t1x9gknd 5803 15 newborn newborn JJ cord-010119-t1x9gknd 5803 16 ( ( -LRB- cord-010119-t1x9gknd 5803 17 HDFN HDFN NNP cord-010119-t1x9gknd 5803 18 ) ) -RRB- cord-010119-t1x9gknd 5803 19 . . . cord-010119-t1x9gknd 5804 1 Ge Ge NNP cord-010119-t1x9gknd 5804 2 antibodies antibody NNS cord-010119-t1x9gknd 5804 3 also also RB cord-010119-t1x9gknd 5804 4 suppress suppress VBP cord-010119-t1x9gknd 5804 5 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 5804 6 resulting result VBG cord-010119-t1x9gknd 5804 7 in in IN cord-010119-t1x9gknd 5804 8 late late JJ cord-010119-t1x9gknd 5804 9 - - HYPH cord-010119-t1x9gknd 5804 10 onset onset NN cord-010119-t1x9gknd 5804 11 anemia anemia NN cord-010119-t1x9gknd 5804 12 . . . cord-010119-t1x9gknd 5805 1 We -PRON- PRP cord-010119-t1x9gknd 5805 2 report report VBP cord-010119-t1x9gknd 5805 3 a a DT cord-010119-t1x9gknd 5805 4 case case NN cord-010119-t1x9gknd 5805 5 of of IN cord-010119-t1x9gknd 5805 6 HDFN HDFN NNP cord-010119-t1x9gknd 5805 7 due due IN cord-010119-t1x9gknd 5805 8 to to IN cord-010119-t1x9gknd 5805 9 anti anti JJ cord-010119-t1x9gknd 5805 10 - - JJ cord-010119-t1x9gknd 5805 11 Ge3 ge3 JJ cord-010119-t1x9gknd 5805 12 . . . cord-010119-t1x9gknd 5806 1 Study Study NNP cord-010119-t1x9gknd 5806 2 Design Design NNP cord-010119-t1x9gknd 5806 3 / / SYM cord-010119-t1x9gknd 5806 4 Methods method NNS cord-010119-t1x9gknd 5806 5 : : : cord-010119-t1x9gknd 5807 1 A a DT cord-010119-t1x9gknd 5807 2 woman woman NN cord-010119-t1x9gknd 5807 3 of of IN cord-010119-t1x9gknd 5807 4 Paraguayan paraguayan JJ cord-010119-t1x9gknd 5807 5 origin origin NN cord-010119-t1x9gknd 5807 6 with with IN cord-010119-t1x9gknd 5807 7 prior prior JJ cord-010119-t1x9gknd 5807 8 terminated terminate VBN cord-010119-t1x9gknd 5807 9 pregnancies pregnancy NNS cord-010119-t1x9gknd 5807 10 presented present VBN cord-010119-t1x9gknd 5807 11 at at IN cord-010119-t1x9gknd 5807 12 24 24 CD cord-010119-t1x9gknd 5807 13 weeks week NNS cord-010119-t1x9gknd 5807 14 gestation gestation NN cord-010119-t1x9gknd 5807 15 with with IN cord-010119-t1x9gknd 5807 16 passive passive JJ cord-010119-t1x9gknd 5807 17 anti anti JJ cord-010119-t1x9gknd 5807 18 - - JJ cord-010119-t1x9gknd 5807 19 D d JJ cord-010119-t1x9gknd 5807 20 and and CC cord-010119-t1x9gknd 5807 21 an an DT cord-010119-t1x9gknd 5807 22 anti anti JJ cord-010119-t1x9gknd 5807 23 - - JJ cord-010119-t1x9gknd 5807 24 Ge3 ge3 JJ cord-010119-t1x9gknd 5807 25 titer titer NN cord-010119-t1x9gknd 5807 26 of of IN cord-010119-t1x9gknd 5807 27 256 256 CD cord-010119-t1x9gknd 5807 28 . . . cord-010119-t1x9gknd 5808 1 She -PRON- PRP cord-010119-t1x9gknd 5808 2 was be VBD cord-010119-t1x9gknd 5808 3 D d NN cord-010119-t1x9gknd 5808 4 - - , cord-010119-t1x9gknd 5808 5 and and CC cord-010119-t1x9gknd 5808 6 GE:-2,-3 GE:-2,-3 NNP cord-010119-t1x9gknd 5808 7 , , , cord-010119-t1x9gknd 5808 8 4 4 CD cord-010119-t1x9gknd 5808 9 by by IN cord-010119-t1x9gknd 5808 10 antigen antigen NN cord-010119-t1x9gknd 5808 11 typing typing NN cord-010119-t1x9gknd 5808 12 . . . cord-010119-t1x9gknd 5809 1 Her -PRON- PRP$ cord-010119-t1x9gknd 5809 2 obstetrician obstetrician NN cord-010119-t1x9gknd 5809 3 scheduled schedule VBD cord-010119-t1x9gknd 5809 4 maternal maternal JJ cord-010119-t1x9gknd 5809 5 blood blood NN cord-010119-t1x9gknd 5809 6 collection collection NN cord-010119-t1x9gknd 5809 7 near near IN cord-010119-t1x9gknd 5809 8 her -PRON- PRP$ cord-010119-t1x9gknd 5809 9 due due JJ cord-010119-t1x9gknd 5809 10 date date NN cord-010119-t1x9gknd 5809 11 for for IN cord-010119-t1x9gknd 5809 12 possible possible JJ cord-010119-t1x9gknd 5809 13 neonatal neonatal JJ cord-010119-t1x9gknd 5809 14 transfusion transfusion NN cord-010119-t1x9gknd 5809 15 , , , cord-010119-t1x9gknd 5809 16 but but CC cord-010119-t1x9gknd 5809 17 the the DT cord-010119-t1x9gknd 5809 18 woman woman NN cord-010119-t1x9gknd 5809 19 went go VBD cord-010119-t1x9gknd 5809 20 into into IN cord-010119-t1x9gknd 5809 21 labor labor NN cord-010119-t1x9gknd 5809 22 at at IN cord-010119-t1x9gknd 5809 23 37 37 CD cord-010119-t1x9gknd 5809 24 weeks week NNS cord-010119-t1x9gknd 5809 25 . . . cord-010119-t1x9gknd 5810 1 Cord cord NN cord-010119-t1x9gknd 5810 2 blood blood NN cord-010119-t1x9gknd 5810 3 was be VBD cord-010119-t1x9gknd 5810 4 DAT DAT NNP cord-010119-t1x9gknd 5810 5 positive positive JJ cord-010119-t1x9gknd 5810 6 for for IN cord-010119-t1x9gknd 5810 7 IgG IgG NNP cord-010119-t1x9gknd 5810 8 ; ; : cord-010119-t1x9gknd 5810 9 the the DT cord-010119-t1x9gknd 5810 10 eluate eluate NNP cord-010119-t1x9gknd 5810 11 confirmed confirm VBD cord-010119-t1x9gknd 5810 12 anti anti JJ cord-010119-t1x9gknd 5810 13 - - JJ cord-010119-t1x9gknd 5810 14 D d JJ cord-010119-t1x9gknd 5810 15 and and CC cord-010119-t1x9gknd 5810 16 anti anti JJ cord-010119-t1x9gknd 5810 17 - - JJ cord-010119-t1x9gknd 5810 18 Ge3 ge3 JJ cord-010119-t1x9gknd 5810 19 . . . cord-010119-t1x9gknd 5811 1 The the DT cord-010119-t1x9gknd 5811 2 birth birth NN cord-010119-t1x9gknd 5811 3 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5811 4 ( ( -LRB- cord-010119-t1x9gknd 5811 5 Hgb Hgb NNP cord-010119-t1x9gknd 5811 6 ) ) -RRB- cord-010119-t1x9gknd 5811 7 was be VBD cord-010119-t1x9gknd 5811 8 12.6 12.6 CD cord-010119-t1x9gknd 5811 9 g g NN cord-010119-t1x9gknd 5811 10 / / SYM cord-010119-t1x9gknd 5811 11 dL dl NN cord-010119-t1x9gknd 5811 12 , , , cord-010119-t1x9gknd 5811 13 reticulocyte reticulocyte NNP cord-010119-t1x9gknd 5811 14 ( ( -LRB- cord-010119-t1x9gknd 5811 15 retic retic NNP cord-010119-t1x9gknd 5811 16 ) ) -RRB- cord-010119-t1x9gknd 5811 17 was be VBD cord-010119-t1x9gknd 5811 18 8.6 8.6 CD cord-010119-t1x9gknd 5811 19 % % NN cord-010119-t1x9gknd 5811 20 , , , cord-010119-t1x9gknd 5811 21 bilirubin bilirubin NNP cord-010119-t1x9gknd 5811 22 ( ( -LRB- cord-010119-t1x9gknd 5811 23 bili bili NNP cord-010119-t1x9gknd 5811 24 ) ) -RRB- cord-010119-t1x9gknd 5811 25 was be VBD cord-010119-t1x9gknd 5811 26 2.8 2.8 CD cord-010119-t1x9gknd 5811 27 mg mg NNP cord-010119-t1x9gknd 5811 28 / / SYM cord-010119-t1x9gknd 5811 29 dL dl NN cord-010119-t1x9gknd 5811 30 ; ; : cord-010119-t1x9gknd 5811 31 the the DT cord-010119-t1x9gknd 5811 32 infant infant NN cord-010119-t1x9gknd 5811 33 was be VBD cord-010119-t1x9gknd 5811 34 discharged discharge VBN cord-010119-t1x9gknd 5811 35 . . . cord-010119-t1x9gknd 5812 1 On on IN cord-010119-t1x9gknd 5812 2 day day NN cord-010119-t1x9gknd 5812 3 7 7 CD cord-010119-t1x9gknd 5812 4 of of IN cord-010119-t1x9gknd 5812 5 life life NN cord-010119-t1x9gknd 5812 6 , , , cord-010119-t1x9gknd 5812 7 the the DT cord-010119-t1x9gknd 5812 8 infant infant NN cord-010119-t1x9gknd 5812 9 was be VBD cord-010119-t1x9gknd 5812 10 referred refer VBN cord-010119-t1x9gknd 5812 11 to to IN cord-010119-t1x9gknd 5812 12 Pediatric Pediatric NNP cord-010119-t1x9gknd 5812 13 Hematology Hematology NNP cord-010119-t1x9gknd 5812 14 for for IN cord-010119-t1x9gknd 5812 15 lethargy lethargy NN cord-010119-t1x9gknd 5812 16 and and CC cord-010119-t1x9gknd 5812 17 poor poor JJ cord-010119-t1x9gknd 5812 18 feeding feeding NN cord-010119-t1x9gknd 5812 19 , , , cord-010119-t1x9gknd 5812 20 with with IN cord-010119-t1x9gknd 5812 21 Hgb Hgb NNP cord-010119-t1x9gknd 5812 22 7.6 7.6 CD cord-010119-t1x9gknd 5812 23 g g NN cord-010119-t1x9gknd 5812 24 / / SYM cord-010119-t1x9gknd 5812 25 dL dl NN cord-010119-t1x9gknd 5812 26 , , , cord-010119-t1x9gknd 5812 27 retic retic NNP cord-010119-t1x9gknd 5812 28 2.6 2.6 CD cord-010119-t1x9gknd 5812 29 % % NN cord-010119-t1x9gknd 5812 30 , , , cord-010119-t1x9gknd 5812 31 and and CC cord-010119-t1x9gknd 5812 32 bili bili NNP cord-010119-t1x9gknd 5812 33 6.6 6.6 CD cord-010119-t1x9gknd 5813 1 mg mg NNP cord-010119-t1x9gknd 5813 2 / / SYM cord-010119-t1x9gknd 5813 3 dL. dL. NNP cord-010119-t1x9gknd 5814 1 Ge3-blood ge3-blood NN cord-010119-t1x9gknd 5814 2 was be VBD cord-010119-t1x9gknd 5814 3 not not RB cord-010119-t1x9gknd 5814 4 available available JJ cord-010119-t1x9gknd 5814 5 from from IN cord-010119-t1x9gknd 5814 6 the the DT cord-010119-t1x9gknd 5814 7 blood blood NN cord-010119-t1x9gknd 5814 8 center center NN cord-010119-t1x9gknd 5814 9 or or CC cord-010119-t1x9gknd 5814 10 rare rare JJ cord-010119-t1x9gknd 5814 11 donor donor NN cord-010119-t1x9gknd 5814 12 registry registry NN cord-010119-t1x9gknd 5814 13 . . . cord-010119-t1x9gknd 5815 1 The the DT cord-010119-t1x9gknd 5815 2 mother mother NN cord-010119-t1x9gknd 5815 3 was be VBD cord-010119-t1x9gknd 5815 4 B B NNP cord-010119-t1x9gknd 5815 5 Rh Rh NNP cord-010119-t1x9gknd 5815 6 - - , cord-010119-t1x9gknd 5815 7 and and CC cord-010119-t1x9gknd 5815 8 baby baby NN cord-010119-t1x9gknd 5815 9 was be VBD cord-010119-t1x9gknd 5815 10 B b NN cord-010119-t1x9gknd 5815 11 Rh1 rh1 NN cord-010119-t1x9gknd 5815 12 . . . cord-010119-t1x9gknd 5816 1 Obstetrics obstetric NNS cord-010119-t1x9gknd 5816 2 had have VBD cord-010119-t1x9gknd 5816 3 to to TO cord-010119-t1x9gknd 5816 4 authorize authorize VB cord-010119-t1x9gknd 5816 5 maternal maternal JJ cord-010119-t1x9gknd 5816 6 blood blood NN cord-010119-t1x9gknd 5816 7 donation donation NN cord-010119-t1x9gknd 5816 8 due due IN cord-010119-t1x9gknd 5816 9 to to IN cord-010119-t1x9gknd 5816 10 her -PRON- PRP$ cord-010119-t1x9gknd 5816 11 Hgb Hgb NNP cord-010119-t1x9gknd 5816 12 of of IN cord-010119-t1x9gknd 5816 13 10.9 10.9 CD cord-010119-t1x9gknd 5816 14 g g NN cord-010119-t1x9gknd 5816 15 / / SYM cord-010119-t1x9gknd 5816 16 dL. dL. NNP cord-010119-t1x9gknd 5816 17 Maternal maternal JJ cord-010119-t1x9gknd 5816 18 blood blood NN cord-010119-t1x9gknd 5816 19 collection collection NN cord-010119-t1x9gknd 5816 20 and and CC cord-010119-t1x9gknd 5816 21 RBC RBC NNP cord-010119-t1x9gknd 5816 22 washing washing NN cord-010119-t1x9gknd 5816 23 was be VBD cord-010119-t1x9gknd 5816 24 expedited expedite VBN cord-010119-t1x9gknd 5816 25 and and CC cord-010119-t1x9gknd 5816 26 the the DT cord-010119-t1x9gknd 5816 27 infant infant NN cord-010119-t1x9gknd 5816 28 received receive VBD cord-010119-t1x9gknd 5816 29 40mL 40ml CD cord-010119-t1x9gknd 5816 30 of of IN cord-010119-t1x9gknd 5816 31 maternal maternal JJ cord-010119-t1x9gknd 5816 32 RBCs rbc NNS cord-010119-t1x9gknd 5816 33 within within IN cord-010119-t1x9gknd 5816 34 24 24 CD cord-010119-t1x9gknd 5816 35 hours hour NNS cord-010119-t1x9gknd 5816 36 , , , cord-010119-t1x9gknd 5816 37 at at IN cord-010119-t1x9gknd 5816 38 which which WDT cord-010119-t1x9gknd 5816 39 time time NN cord-010119-t1x9gknd 5816 40 his -PRON- PRP$ cord-010119-t1x9gknd 5816 41 Hgb Hgb NNP cord-010119-t1x9gknd 5816 42 was be VBD cord-010119-t1x9gknd 5817 1 6.1 6.1 CD cord-010119-t1x9gknd 5817 2 g g NN cord-010119-t1x9gknd 5817 3 / / SYM cord-010119-t1x9gknd 5817 4 dL. dl. JJ cord-010119-t1x9gknd 5817 5 Post Post NNP cord-010119-t1x9gknd 5817 6 - - JJ cord-010119-t1x9gknd 5817 7 transfusion transfusion NN cord-010119-t1x9gknd 5817 8 Hgb Hgb NNP cord-010119-t1x9gknd 5817 9 was be VBD cord-010119-t1x9gknd 5817 10 10.8 10.8 CD cord-010119-t1x9gknd 5817 11 g g NN cord-010119-t1x9gknd 5817 12 / / SYM cord-010119-t1x9gknd 5817 13 dL. dl. NN cord-010119-t1x9gknd 5818 1 One one CD cord-010119-t1x9gknd 5818 2 week week NN cord-010119-t1x9gknd 5818 3 later later RB cord-010119-t1x9gknd 5818 4 , , , cord-010119-t1x9gknd 5818 5 the the DT cord-010119-t1x9gknd 5818 6 infant infant NN cord-010119-t1x9gknd 5818 7 was be VBD cord-010119-t1x9gknd 5818 8 symptomatic symptomatic JJ cord-010119-t1x9gknd 5818 9 with with IN cord-010119-t1x9gknd 5818 10 Hgb Hgb NNP cord-010119-t1x9gknd 5818 11 7.1 7.1 CD cord-010119-t1x9gknd 5818 12 g g NNP cord-010119-t1x9gknd 5818 13 / / SYM cord-010119-t1x9gknd 5818 14 dL dl NN cord-010119-t1x9gknd 5818 15 , , , cord-010119-t1x9gknd 5818 16 retic retic NN cord-010119-t1x9gknd 5818 17 1.0 1.0 CD cord-010119-t1x9gknd 5818 18 % % NN cord-010119-t1x9gknd 5818 19 , , , cord-010119-t1x9gknd 5818 20 bili bili NNP cord-010119-t1x9gknd 5818 21 2.1 2.1 CD cord-010119-t1x9gknd 5818 22 mg mg NNP cord-010119-t1x9gknd 5819 1 /dL. /dL. . cord-010119-t1x9gknd 5820 1 A a DT cord-010119-t1x9gknd 5820 2 2 2 CD cord-010119-t1x9gknd 5820 3 nd nd NNP cord-010119-t1x9gknd 5820 4 aliquot aliquot NN cord-010119-t1x9gknd 5820 5 of of IN cord-010119-t1x9gknd 5820 6 60mL 60ml CD cord-010119-t1x9gknd 5820 7 washed wash VBN cord-010119-t1x9gknd 5820 8 maternal maternal JJ cord-010119-t1x9gknd 5820 9 cells cell NNS cord-010119-t1x9gknd 5820 10 was be VBD cord-010119-t1x9gknd 5820 11 transfused transfuse VBN cord-010119-t1x9gknd 5820 12 . . . cord-010119-t1x9gknd 5821 1 Two two CD cord-010119-t1x9gknd 5821 2 weeks week NNS cord-010119-t1x9gknd 5821 3 thereafter thereafter RB cord-010119-t1x9gknd 5821 4 , , , cord-010119-t1x9gknd 5821 5 the the DT cord-010119-t1x9gknd 5821 6 infant infant NN cord-010119-t1x9gknd 5821 7 had have VBD cord-010119-t1x9gknd 5821 8 Hgb Hgb NNP cord-010119-t1x9gknd 5821 9 7.8 7.8 CD cord-010119-t1x9gknd 5821 10 g g NN cord-010119-t1x9gknd 5821 11 / / SYM cord-010119-t1x9gknd 5821 12 dL dl NN cord-010119-t1x9gknd 5821 13 , , , cord-010119-t1x9gknd 5821 14 retic retic NN cord-010119-t1x9gknd 5821 15 0.7 0.7 CD cord-010119-t1x9gknd 5821 16 % % NN cord-010119-t1x9gknd 5821 17 , , , cord-010119-t1x9gknd 5821 18 anti anti JJ cord-010119-t1x9gknd 5821 19 - - JJ cord-010119-t1x9gknd 5821 20 Ge3 ge3 JJ cord-010119-t1x9gknd 5821 21 titer titer NN cord-010119-t1x9gknd 5821 22 8 8 CD cord-010119-t1x9gknd 5821 23 , , , cord-010119-t1x9gknd 5821 24 and and CC cord-010119-t1x9gknd 5821 25 needed need VBD cord-010119-t1x9gknd 5821 26 another another DT cord-010119-t1x9gknd 5821 27 transfusion transfusion NN cord-010119-t1x9gknd 5821 28 . . . cord-010119-t1x9gknd 5822 1 The the DT cord-010119-t1x9gknd 5822 2 maternal maternal JJ cord-010119-t1x9gknd 5822 3 blood blood NN cord-010119-t1x9gknd 5822 4 stored store VBN cord-010119-t1x9gknd 5822 5 for for IN cord-010119-t1x9gknd 5822 6 just just RB cord-010119-t1x9gknd 5822 7 3 3 CD cord-010119-t1x9gknd 5822 8 weeks week NNS cord-010119-t1x9gknd 5822 9 had have VBD cord-010119-t1x9gknd 5822 10 hemolyzed hemolyze VBN cord-010119-t1x9gknd 5822 11 necessitating necessitate VBG cord-010119-t1x9gknd 5822 12 a a DT cord-010119-t1x9gknd 5822 13 2nd 2nd JJ cord-010119-t1x9gknd 5822 14 maternal maternal JJ cord-010119-t1x9gknd 5822 15 donation donation NN cord-010119-t1x9gknd 5822 16 for for IN cord-010119-t1x9gknd 5822 17 baby baby NN cord-010119-t1x9gknd 5822 18 's 's POS cord-010119-t1x9gknd 5822 19 3 3 CD cord-010119-t1x9gknd 5822 20 rd rd NN cord-010119-t1x9gknd 5822 21 transfusion transfusion NN cord-010119-t1x9gknd 5822 22 . . . cord-010119-t1x9gknd 5823 1 At at IN cord-010119-t1x9gknd 5823 2 6 6 CD cord-010119-t1x9gknd 5823 3 weeks week NNS cord-010119-t1x9gknd 5823 4 , , , cord-010119-t1x9gknd 5823 5 the the DT cord-010119-t1x9gknd 5823 6 infant infant NN cord-010119-t1x9gknd 5823 7 's 's POS cord-010119-t1x9gknd 5823 8 anti anti JJ cord-010119-t1x9gknd 5823 9 - - JJ cord-010119-t1x9gknd 5823 10 Ge3 ge3 JJ cord-010119-t1x9gknd 5823 11 titer titer NN cord-010119-t1x9gknd 5823 12 was be VBD cord-010119-t1x9gknd 5823 13 2 2 CD cord-010119-t1x9gknd 5823 14 , , , cord-010119-t1x9gknd 5823 15 Hgb Hgb NNP cord-010119-t1x9gknd 5823 16 9.2 9.2 CD cord-010119-t1x9gknd 5823 17 g g NN cord-010119-t1x9gknd 5823 18 / / SYM cord-010119-t1x9gknd 5823 19 dL dl NN cord-010119-t1x9gknd 5823 20 , , , cord-010119-t1x9gknd 5823 21 retic retic NN cord-010119-t1x9gknd 5823 22 1.7 1.7 CD cord-010119-t1x9gknd 5823 23 % % NN cord-010119-t1x9gknd 5823 24 ; ; : cord-010119-t1x9gknd 5823 25 no no DT cord-010119-t1x9gknd 5823 26 transfusion transfusion NN cord-010119-t1x9gknd 5823 27 was be VBD cord-010119-t1x9gknd 5823 28 necessary necessary JJ cord-010119-t1x9gknd 5823 29 . . . cord-010119-t1x9gknd 5824 1 At at IN cord-010119-t1x9gknd 5824 2 8 8 CD cord-010119-t1x9gknd 5824 3 weeks week NNS cord-010119-t1x9gknd 5824 4 of of IN cord-010119-t1x9gknd 5824 5 life life NN cord-010119-t1x9gknd 5824 6 , , , cord-010119-t1x9gknd 5824 7 Hgb Hgb NNP cord-010119-t1x9gknd 5824 8 was be VBD cord-010119-t1x9gknd 5824 9 10.2 10.2 CD cord-010119-t1x9gknd 5824 10 g g NN cord-010119-t1x9gknd 5824 11 / / SYM cord-010119-t1x9gknd 5824 12 dL dl NN cord-010119-t1x9gknd 5824 13 , , , cord-010119-t1x9gknd 5824 14 retic retic NN cord-010119-t1x9gknd 5824 15 was be VBD cord-010119-t1x9gknd 5824 16 3.3 3.3 CD cord-010119-t1x9gknd 5824 17 % % NN cord-010119-t1x9gknd 5824 18 , , , cord-010119-t1x9gknd 5824 19 and and CC cord-010119-t1x9gknd 5824 20 the the DT cord-010119-t1x9gknd 5824 21 baby baby NN cord-010119-t1x9gknd 5824 22 was be VBD cord-010119-t1x9gknd 5824 23 thriving thrive VBG cord-010119-t1x9gknd 5824 24 . . . cord-010119-t1x9gknd 5825 1 Results result NNS cord-010119-t1x9gknd 5825 2 / / SYM cord-010119-t1x9gknd 5825 3 Findings finding NNS cord-010119-t1x9gknd 5825 4 : : : cord-010119-t1x9gknd 5826 1 Serologic Serologic NNP cord-010119-t1x9gknd 5826 2 studies study NNS cord-010119-t1x9gknd 5826 3 at at IN cord-010119-t1x9gknd 5826 4 the the DT cord-010119-t1x9gknd 5826 5 hospital hospital NN cord-010119-t1x9gknd 5826 6 and and CC cord-010119-t1x9gknd 5826 7 reference reference NN cord-010119-t1x9gknd 5826 8 blood blood NN cord-010119-t1x9gknd 5826 9 center center NN cord-010119-t1x9gknd 5826 10 confirmed confirm VBD cord-010119-t1x9gknd 5826 11 the the DT cord-010119-t1x9gknd 5826 12 antibodies antibody NNS cord-010119-t1x9gknd 5826 13 and and CC cord-010119-t1x9gknd 5826 14 risk risk NN cord-010119-t1x9gknd 5826 15 of of IN cord-010119-t1x9gknd 5826 16 anti anti JJ cord-010119-t1x9gknd 5826 17 - - JJ cord-010119-t1x9gknd 5826 18 Ge3 ge3 JJ cord-010119-t1x9gknd 5826 19 HDFN HDFN NNP cord-010119-t1x9gknd 5826 20 . . . cord-010119-t1x9gknd 5827 1 Molecular molecular JJ cord-010119-t1x9gknd 5827 2 analysis analysis NN cord-010119-t1x9gknd 5827 3 revealed reveal VBD cord-010119-t1x9gknd 5827 4 that that IN cord-010119-t1x9gknd 5827 5 the the DT cord-010119-t1x9gknd 5827 6 mother mother NN cord-010119-t1x9gknd 5827 7 was be VBD cord-010119-t1x9gknd 5827 8 homozygous homozygous JJ cord-010119-t1x9gknd 5827 9 Ge3-negative Ge3-negative NNP cord-010119-t1x9gknd 5827 10 GE*01.-03 GE*01.-03 NNP cord-010119-t1x9gknd 5827 11 , , , cord-010119-t1x9gknd 5827 12 the the DT cord-010119-t1x9gknd 5827 13 father father NN cord-010119-t1x9gknd 5827 14 had have VBD cord-010119-t1x9gknd 5827 15 homozygous homozygous JJ cord-010119-t1x9gknd 5827 16 wild wild JJ cord-010119-t1x9gknd 5827 17 type type NN cord-010119-t1x9gknd 5827 18 GE*01 ge*01 NN cord-010119-t1x9gknd 5827 19 , , , cord-010119-t1x9gknd 5827 20 and and CC cord-010119-t1x9gknd 5827 21 the the DT cord-010119-t1x9gknd 5827 22 infant infant NN cord-010119-t1x9gknd 5827 23 was be VBD cord-010119-t1x9gknd 5827 24 heterozygous heterozygous JJ cord-010119-t1x9gknd 5828 1 GE*01 GE*01 NNS cord-010119-t1x9gknd 5828 2 / / SYM cord-010119-t1x9gknd 5828 3 GE*01.-03 GE*01.-03 NNP cord-010119-t1x9gknd 5828 4 . . . cord-010119-t1x9gknd 5829 1 Conclusion conclusion NN cord-010119-t1x9gknd 5829 2 : : : cord-010119-t1x9gknd 5830 1 The the DT cord-010119-t1x9gknd 5830 2 infant infant NN cord-010119-t1x9gknd 5830 3 had have VBD cord-010119-t1x9gknd 5830 4 HDFN HDFN NNP cord-010119-t1x9gknd 5830 5 due due IN cord-010119-t1x9gknd 5830 6 to to IN cord-010119-t1x9gknd 5830 7 antibodies antibody NNS cord-010119-t1x9gknd 5830 8 to to IN cord-010119-t1x9gknd 5830 9 the the DT cord-010119-t1x9gknd 5830 10 high high JJ cord-010119-t1x9gknd 5830 11 prevalence prevalence NN cord-010119-t1x9gknd 5830 12 Ge3 ge3 NN cord-010119-t1x9gknd 5830 13 antigen antigen NN cord-010119-t1x9gknd 5830 14 . . . cord-010119-t1x9gknd 5831 1 The the DT cord-010119-t1x9gknd 5831 2 continued continue VBN cord-010119-t1x9gknd 5831 3 need need NN cord-010119-t1x9gknd 5831 4 for for IN cord-010119-t1x9gknd 5831 5 transfusion transfusion NN cord-010119-t1x9gknd 5831 6 was be VBD cord-010119-t1x9gknd 5831 7 consistent consistent JJ cord-010119-t1x9gknd 5831 8 with with IN cord-010119-t1x9gknd 5831 9 hemolysis hemolysis NN cord-010119-t1x9gknd 5831 10 and and CC cord-010119-t1x9gknd 5831 11 suppression suppression NN cord-010119-t1x9gknd 5831 12 of of IN cord-010119-t1x9gknd 5831 13 erythrocyte erythrocyte NN cord-010119-t1x9gknd 5831 14 production production NN cord-010119-t1x9gknd 5831 15 caused cause VBN cord-010119-t1x9gknd 5831 16 by by IN cord-010119-t1x9gknd 5831 17 anti anti JJ cord-010119-t1x9gknd 5831 18 - - JJ cord-010119-t1x9gknd 5831 19 Ge3 ge3 JJ cord-010119-t1x9gknd 5831 20 . . . cord-010119-t1x9gknd 5832 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 5832 2 of of IN cord-010119-t1x9gknd 5832 3 stored store VBN cord-010119-t1x9gknd 5832 4 maternal maternal JJ cord-010119-t1x9gknd 5832 5 blood blood NN cord-010119-t1x9gknd 5832 6 was be VBD cord-010119-t1x9gknd 5832 7 consistent consistent JJ cord-010119-t1x9gknd 5832 8 with with IN cord-010119-t1x9gknd 5832 9 the the DT cord-010119-t1x9gknd 5832 10 absence absence NN cord-010119-t1x9gknd 5832 11 of of IN cord-010119-t1x9gknd 5832 12 glycophorin glycophorin NNP cord-010119-t1x9gknd 5832 13 C. C. NNP cord-010119-t1x9gknd 5833 1 This this DT cord-010119-t1x9gknd 5833 2 case case NN cord-010119-t1x9gknd 5833 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 5833 4 that that IN cord-010119-t1x9gknd 5833 5 cooperative cooperative JJ cord-010119-t1x9gknd 5833 6 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 5833 7 care care NN cord-010119-t1x9gknd 5833 8 among among IN cord-010119-t1x9gknd 5833 9 the the DT cord-010119-t1x9gknd 5833 10 blood blood NN cord-010119-t1x9gknd 5833 11 bank bank NN cord-010119-t1x9gknd 5833 12 , , , cord-010119-t1x9gknd 5833 13 donor donor NN cord-010119-t1x9gknd 5833 14 center center NN cord-010119-t1x9gknd 5833 15 , , , cord-010119-t1x9gknd 5833 16 obstetrics obstetric NNS cord-010119-t1x9gknd 5833 17 , , , cord-010119-t1x9gknd 5833 18 and and CC cord-010119-t1x9gknd 5833 19 hematology hematology NN cord-010119-t1x9gknd 5833 20 in in IN cord-010119-t1x9gknd 5833 21 a a DT cord-010119-t1x9gknd 5833 22 rare rare JJ cord-010119-t1x9gknd 5833 23 case case NN cord-010119-t1x9gknd 5833 24 of of IN cord-010119-t1x9gknd 5833 25 HDFN HDFN NNP cord-010119-t1x9gknd 5833 26 resulted result VBD cord-010119-t1x9gknd 5833 27 in in IN cord-010119-t1x9gknd 5833 28 a a DT cord-010119-t1x9gknd 5833 29 successful successful JJ cord-010119-t1x9gknd 5833 30 neonatal neonatal JJ cord-010119-t1x9gknd 5833 31 outcome outcome NN cord-010119-t1x9gknd 5833 32 . . . cord-010119-t1x9gknd 5834 1 Background Background NNP cord-010119-t1x9gknd 5834 2 / / SYM cord-010119-t1x9gknd 5834 3 Case Case NNP cord-010119-t1x9gknd 5834 4 Studies Studies NNPS cord-010119-t1x9gknd 5834 5 : : : cord-010119-t1x9gknd 5834 6 Patient patient JJ cord-010119-t1x9gknd 5834 7 blood blood NN cord-010119-t1x9gknd 5834 8 management management NN cord-010119-t1x9gknd 5834 9 is be VBZ cord-010119-t1x9gknd 5834 10 a a DT cord-010119-t1x9gknd 5834 11 collaborative collaborative JJ cord-010119-t1x9gknd 5834 12 approach approach NN cord-010119-t1x9gknd 5834 13 to to TO cord-010119-t1x9gknd 5834 14 optimize optimize VB cord-010119-t1x9gknd 5834 15 transfusion transfusion NN cord-010119-t1x9gknd 5834 16 therapies therapy NNS cord-010119-t1x9gknd 5834 17 to to TO cord-010119-t1x9gknd 5834 18 improve improve VB cord-010119-t1x9gknd 5834 19 patient patient JJ cord-010119-t1x9gknd 5834 20 outcomes outcome NNS cord-010119-t1x9gknd 5834 21 . . . cord-010119-t1x9gknd 5835 1 In in IN cord-010119-t1x9gknd 5835 2 pediatrics pediatric NNS cord-010119-t1x9gknd 5835 3 , , , cord-010119-t1x9gknd 5835 4 blood blood NN cord-010119-t1x9gknd 5835 5 management management NN cord-010119-t1x9gknd 5835 6 is be VBZ cord-010119-t1x9gknd 5835 7 not not RB cord-010119-t1x9gknd 5835 8 ' ' `` cord-010119-t1x9gknd 5835 9 one one CD cord-010119-t1x9gknd 5835 10 size size NN cord-010119-t1x9gknd 5835 11 fits fit VBZ cord-010119-t1x9gknd 5835 12 all all DT cord-010119-t1x9gknd 5835 13 ' ' `` cord-010119-t1x9gknd 5835 14 given give VBN cord-010119-t1x9gknd 5835 15 the the DT cord-010119-t1x9gknd 5835 16 paucity paucity NN cord-010119-t1x9gknd 5835 17 of of IN cord-010119-t1x9gknd 5835 18 clinical clinical JJ cord-010119-t1x9gknd 5835 19 trials trial NNS cord-010119-t1x9gknd 5835 20 to to TO cord-010119-t1x9gknd 5835 21 guide guide VB cord-010119-t1x9gknd 5835 22 evidence evidence NN cord-010119-t1x9gknd 5835 23 - - HYPH cord-010119-t1x9gknd 5835 24 based base VBN cord-010119-t1x9gknd 5835 25 practice practice NN cord-010119-t1x9gknd 5835 26 . . . cord-010119-t1x9gknd 5836 1 In in IN cord-010119-t1x9gknd 5836 2 addition addition NN cord-010119-t1x9gknd 5836 3 , , , cord-010119-t1x9gknd 5836 4 pediatric pediatric JJ cord-010119-t1x9gknd 5836 5 care care NN cord-010119-t1x9gknd 5836 6 encompasses encompass VBZ cord-010119-t1x9gknd 5836 7 a a DT cord-010119-t1x9gknd 5836 8 very very RB cord-010119-t1x9gknd 5836 9 heterogeneous heterogeneous JJ cord-010119-t1x9gknd 5836 10 patient patient NN cord-010119-t1x9gknd 5836 11 population population NN cord-010119-t1x9gknd 5836 12 such such JJ cord-010119-t1x9gknd 5836 13 that that IN cord-010119-t1x9gknd 5836 14 applying apply VBG cord-010119-t1x9gknd 5836 15 one one CD cord-010119-t1x9gknd 5836 16 set set NN cord-010119-t1x9gknd 5836 17 of of IN cord-010119-t1x9gknd 5836 18 guidelines guideline NNS cord-010119-t1x9gknd 5836 19 is be VBZ cord-010119-t1x9gknd 5836 20 difficult difficult JJ cord-010119-t1x9gknd 5836 21 . . . cord-010119-t1x9gknd 5837 1 Because because IN cord-010119-t1x9gknd 5837 2 there there EX cord-010119-t1x9gknd 5837 3 are be VBP cord-010119-t1x9gknd 5837 4 no no DT cord-010119-t1x9gknd 5837 5 standard standard JJ cord-010119-t1x9gknd 5837 6 , , , cord-010119-t1x9gknd 5837 7 evidence evidence NN cord-010119-t1x9gknd 5837 8 - - HYPH cord-010119-t1x9gknd 5837 9 based base VBN cord-010119-t1x9gknd 5837 10 clinical clinical JJ cord-010119-t1x9gknd 5837 11 best good JJS cord-010119-t1x9gknd 5837 12 practices practice NNS cord-010119-t1x9gknd 5837 13 regarding regard VBG cord-010119-t1x9gknd 5837 14 blood blood NN cord-010119-t1x9gknd 5837 15 product product NN cord-010119-t1x9gknd 5837 16 usage usage NN cord-010119-t1x9gknd 5837 17 in in IN cord-010119-t1x9gknd 5837 18 all all DT cord-010119-t1x9gknd 5837 19 children child NNS cord-010119-t1x9gknd 5837 20 , , , cord-010119-t1x9gknd 5837 21 unnecessary unnecessary JJ cord-010119-t1x9gknd 5837 22 variation variation NN cord-010119-t1x9gknd 5837 23 is be VBZ cord-010119-t1x9gknd 5837 24 occurring occur VBG cord-010119-t1x9gknd 5837 25 at at IN cord-010119-t1x9gknd 5837 26 our -PRON- PRP$ cord-010119-t1x9gknd 5837 27 institution institution NN cord-010119-t1x9gknd 5837 28 . . . cord-010119-t1x9gknd 5838 1 We -PRON- PRP cord-010119-t1x9gknd 5838 2 designed design VBD cord-010119-t1x9gknd 5838 3 a a DT cord-010119-t1x9gknd 5838 4 robust robust JJ cord-010119-t1x9gknd 5838 5 analytics analytic NNS cord-010119-t1x9gknd 5838 6 process process NN cord-010119-t1x9gknd 5838 7 to to TO cord-010119-t1x9gknd 5838 8 study study VB cord-010119-t1x9gknd 5838 9 baseline baseline JJ cord-010119-t1x9gknd 5838 10 clinical clinical JJ cord-010119-t1x9gknd 5838 11 practice practice NN cord-010119-t1x9gknd 5838 12 and and CC cord-010119-t1x9gknd 5838 13 examine examine VB cord-010119-t1x9gknd 5838 14 blood blood NN cord-010119-t1x9gknd 5838 15 product product NN cord-010119-t1x9gknd 5838 16 usage usage NN cord-010119-t1x9gknd 5838 17 , , , cord-010119-t1x9gknd 5838 18 and and CC cord-010119-t1x9gknd 5838 19 plan plan VBP cord-010119-t1x9gknd 5838 20 to to TO cord-010119-t1x9gknd 5838 21 target target VB cord-010119-t1x9gknd 5838 22 the the DT cord-010119-t1x9gknd 5838 23 three three CD cord-010119-t1x9gknd 5838 24 pediatric pediatric JJ cord-010119-t1x9gknd 5838 25 sub sub NN cord-010119-t1x9gknd 5838 26 - - HYPH cord-010119-t1x9gknd 5838 27 specialties specialty NNS cord-010119-t1x9gknd 5838 28 with with IN cord-010119-t1x9gknd 5838 29 highest high JJS cord-010119-t1x9gknd 5838 30 usage usage NN cord-010119-t1x9gknd 5838 31 to to TO cord-010119-t1x9gknd 5838 32 establish establish VB cord-010119-t1x9gknd 5838 33 standards standard NNS cord-010119-t1x9gknd 5838 34 in in IN cord-010119-t1x9gknd 5838 35 order order NN cord-010119-t1x9gknd 5838 36 to to TO cord-010119-t1x9gknd 5838 37 decrease decrease VB cord-010119-t1x9gknd 5838 38 variation variation NN cord-010119-t1x9gknd 5838 39 / / SYM cord-010119-t1x9gknd 5838 40 unnecessary unnecessary JJ cord-010119-t1x9gknd 5838 41 transfusions transfusion NNS cord-010119-t1x9gknd 5838 42 . . . cord-010119-t1x9gknd 5839 1 Study Study NNP cord-010119-t1x9gknd 5839 2 Design Design NNP cord-010119-t1x9gknd 5839 3 / / SYM cord-010119-t1x9gknd 5839 4 Methods method NNS cord-010119-t1x9gknd 5839 5 : : : cord-010119-t1x9gknd 5840 1 A a DT cord-010119-t1x9gknd 5840 2 data data NN cord-010119-t1x9gknd 5840 3 base base NN cord-010119-t1x9gknd 5840 4 encompassing encompass VBG cord-010119-t1x9gknd 5840 5 all all DT cord-010119-t1x9gknd 5840 6 admissions admission NNS cord-010119-t1x9gknd 5840 7 and and CC cord-010119-t1x9gknd 5840 8 outpatient outpatient NN cord-010119-t1x9gknd 5840 9 visits visit NNS cord-010119-t1x9gknd 5840 10 to to IN cord-010119-t1x9gknd 5840 11 a a DT cord-010119-t1x9gknd 5840 12 large large JJ cord-010119-t1x9gknd 5840 13 , , , cord-010119-t1x9gknd 5840 14 tertiary tertiary JJ cord-010119-t1x9gknd 5840 15 care care NN cord-010119-t1x9gknd 5840 16 academic academic JJ cord-010119-t1x9gknd 5840 17 children child NNS cord-010119-t1x9gknd 5840 18 's 's POS cord-010119-t1x9gknd 5840 19 and and CC cord-010119-t1x9gknd 5840 20 women woman NNS cord-010119-t1x9gknd 5840 21 's 's POS cord-010119-t1x9gknd 5840 22 hospital hospital NN cord-010119-t1x9gknd 5840 23 was be VBD cord-010119-t1x9gknd 5840 24 established establish VBN cord-010119-t1x9gknd 5840 25 , , , cord-010119-t1x9gknd 5840 26 and and CC cord-010119-t1x9gknd 5840 27 included include VBD cord-010119-t1x9gknd 5840 28 all all DT cord-010119-t1x9gknd 5840 29 relevant relevant JJ cord-010119-t1x9gknd 5840 30 patient patient JJ cord-010119-t1x9gknd 5840 31 demographics demographic NNS cord-010119-t1x9gknd 5840 32 , , , cord-010119-t1x9gknd 5840 33 diagnostic diagnostic JJ cord-010119-t1x9gknd 5840 34 and and CC cord-010119-t1x9gknd 5840 35 procedural procedural JJ cord-010119-t1x9gknd 5840 36 codes code NNS cord-010119-t1x9gknd 5840 37 , , , cord-010119-t1x9gknd 5840 38 attending attend VBG cord-010119-t1x9gknd 5840 39 physician physician NN cord-010119-t1x9gknd 5840 40 and and CC cord-010119-t1x9gknd 5840 41 specialty specialty NN cord-010119-t1x9gknd 5840 42 for for IN cord-010119-t1x9gknd 5840 43 each each DT cord-010119-t1x9gknd 5840 44 visit visit NN cord-010119-t1x9gknd 5840 45 / / SYM cord-010119-t1x9gknd 5840 46 admission admission NN cord-010119-t1x9gknd 5840 47 , , , cord-010119-t1x9gknd 5840 48 relevant relevant JJ cord-010119-t1x9gknd 5840 49 hematology hematology NN cord-010119-t1x9gknd 5840 50 / / SYM cord-010119-t1x9gknd 5840 51 coagulation coagulation NN cord-010119-t1x9gknd 5840 52 laboratory laboratory NN cord-010119-t1x9gknd 5840 53 results result NNS cord-010119-t1x9gknd 5840 54 and and CC cord-010119-t1x9gknd 5840 55 blood blood NN cord-010119-t1x9gknd 5840 56 product product NN cord-010119-t1x9gknd 5840 57 orders order NNS cord-010119-t1x9gknd 5840 58 . . . cord-010119-t1x9gknd 5841 1 We -PRON- PRP cord-010119-t1x9gknd 5841 2 focused focus VBD cord-010119-t1x9gknd 5841 3 on on IN cord-010119-t1x9gknd 5841 4 RBC RBC NNP cord-010119-t1x9gknd 5841 5 orders order NNS cord-010119-t1x9gknd 5841 6 given give VBN cord-010119-t1x9gknd 5841 7 the the DT cord-010119-t1x9gknd 5841 8 TRIPICU TRIPICU NNP cord-010119-t1x9gknd 5841 9 randomized randomize VBD cord-010119-t1x9gknd 5841 10 clinical clinical JJ cord-010119-t1x9gknd 5841 11 trial trial NN cord-010119-t1x9gknd 5841 12 results result NNS cord-010119-t1x9gknd 5841 13 ( ( -LRB- cord-010119-t1x9gknd 5841 14 1 1 CD cord-010119-t1x9gknd 5841 15 ) ) -RRB- cord-010119-t1x9gknd 5841 16 supporting support VBG cord-010119-t1x9gknd 5841 17 a a DT cord-010119-t1x9gknd 5841 18 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5841 19 trigger trigger NN cord-010119-t1x9gknd 5841 20 of of IN cord-010119-t1x9gknd 5841 21 7 7 CD cord-010119-t1x9gknd 5841 22 g g NN cord-010119-t1x9gknd 5841 23 / / SYM cord-010119-t1x9gknd 5841 24 dL dl NN cord-010119-t1x9gknd 5841 25 in in IN cord-010119-t1x9gknd 5841 26 stable stable JJ cord-010119-t1x9gknd 5841 27 critically critically RB cord-010119-t1x9gknd 5841 28 ill ill JJ cord-010119-t1x9gknd 5841 29 children child NNS cord-010119-t1x9gknd 5841 30 and and CC cord-010119-t1x9gknd 5841 31 FFP FFP NNP cord-010119-t1x9gknd 5841 32 since since IN cord-010119-t1x9gknd 5841 33 anecdotally anecdotally RB cord-010119-t1x9gknd 5841 34 we -PRON- PRP cord-010119-t1x9gknd 5841 35 noted note VBD cord-010119-t1x9gknd 5841 36 many many JJ cord-010119-t1x9gknd 5841 37 children child NNS cord-010119-t1x9gknd 5841 38 receiving receive VBG cord-010119-t1x9gknd 5841 39 this this DT cord-010119-t1x9gknd 5841 40 product product NN cord-010119-t1x9gknd 5841 41 for for IN cord-010119-t1x9gknd 5841 42 only only RB cord-010119-t1x9gknd 5841 43 minimally minimally RB cord-010119-t1x9gknd 5841 44 elevated elevated JJ cord-010119-t1x9gknd 5841 45 international international JJ cord-010119-t1x9gknd 5841 46 normalized normalized JJ cord-010119-t1x9gknd 5841 47 ratio ratio NN cord-010119-t1x9gknd 5841 48 ( ( -LRB- cord-010119-t1x9gknd 5841 49 INR INR NNP cord-010119-t1x9gknd 5841 50 ) ) -RRB- cord-010119-t1x9gknd 5841 51 values value NNS cord-010119-t1x9gknd 5841 52 without without IN cord-010119-t1x9gknd 5841 53 bleeding bleed VBG cord-010119-t1x9gknd 5841 54 . . . cord-010119-t1x9gknd 5842 1 Results result NNS cord-010119-t1x9gknd 5842 2 / / SYM cord-010119-t1x9gknd 5842 3 Findings finding NNS cord-010119-t1x9gknd 5842 4 : : : cord-010119-t1x9gknd 5843 1 In in IN cord-010119-t1x9gknd 5843 2 2016 2016 CD cord-010119-t1x9gknd 5843 3 , , , cord-010119-t1x9gknd 5843 4 14 14 CD cord-010119-t1x9gknd 5843 5 , , , cord-010119-t1x9gknd 5843 6 247 247 CD cord-010119-t1x9gknd 5843 7 RBC RBC NNP cord-010119-t1x9gknd 5843 8 orders order NNS cord-010119-t1x9gknd 5843 9 occurred occur VBD cord-010119-t1x9gknd 5843 10 and and CC cord-010119-t1x9gknd 5843 11 the the DT cord-010119-t1x9gknd 5843 12 top top JJ cord-010119-t1x9gknd 5843 13 three three CD cord-010119-t1x9gknd 5843 14 patient patient JJ cord-010119-t1x9gknd 5843 15 groups group NNS cord-010119-t1x9gknd 5843 16 were be VBD cord-010119-t1x9gknd 5843 17 : : : cord-010119-t1x9gknd 5843 18 34 34 CD cord-010119-t1x9gknd 5843 19 % % NN cord-010119-t1x9gknd 5843 20 in in IN cord-010119-t1x9gknd 5843 21 congenital congenital JJ cord-010119-t1x9gknd 5843 22 heart heart NN cord-010119-t1x9gknd 5843 23 disease disease NN cord-010119-t1x9gknd 5843 24 patients patient NNS cord-010119-t1x9gknd 5843 25 , , , cord-010119-t1x9gknd 5843 26 25 25 CD cord-010119-t1x9gknd 5843 27 % % NN cord-010119-t1x9gknd 5843 28 in in IN cord-010119-t1x9gknd 5843 29 hematology hematology NN cord-010119-t1x9gknd 5843 30 / / SYM cord-010119-t1x9gknd 5843 31 oncology oncology NN cord-010119-t1x9gknd 5843 32 patients patient NNS cord-010119-t1x9gknd 5843 33 and and CC cord-010119-t1x9gknd 5843 34 14 14 CD cord-010119-t1x9gknd 5843 35 % % NN cord-010119-t1x9gknd 5843 36 in in IN cord-010119-t1x9gknd 5843 37 neonates neonate NNS cord-010119-t1x9gknd 5843 38 in in IN cord-010119-t1x9gknd 5843 39 the the DT cord-010119-t1x9gknd 5843 40 neonatal neonatal JJ cord-010119-t1x9gknd 5843 41 intensive intensive JJ cord-010119-t1x9gknd 5843 42 care care NN cord-010119-t1x9gknd 5843 43 unit unit NN cord-010119-t1x9gknd 5843 44 ( ( -LRB- cord-010119-t1x9gknd 5843 45 NICU NICU NNP cord-010119-t1x9gknd 5843 46 ) ) -RRB- cord-010119-t1x9gknd 5843 47 . . . cord-010119-t1x9gknd 5844 1 Average average JJ cord-010119-t1x9gknd 5844 2 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5844 3 of of IN cord-010119-t1x9gknd 5844 4 every every DT cord-010119-t1x9gknd 5844 5 patient patient NN cord-010119-t1x9gknd 5844 6 was be VBD cord-010119-t1x9gknd 5844 7 9.85 9.85 CD cord-010119-t1x9gknd 5844 8 g g NN cord-010119-t1x9gknd 5844 9 / / SYM cord-010119-t1x9gknd 5844 10 dL dl NN cord-010119-t1x9gknd 5844 11 as as IN cord-010119-t1x9gknd 5844 12 measured measure VBN cord-010119-t1x9gknd 5844 13 in in IN cord-010119-t1x9gknd 5844 14 the the DT cord-010119-t1x9gknd 5844 15 72 72 CD cord-010119-t1x9gknd 5844 16 hours hour NNS cord-010119-t1x9gknd 5844 17 prior prior RB cord-010119-t1x9gknd 5844 18 to to IN cord-010119-t1x9gknd 5844 19 RBC RBC NNP cord-010119-t1x9gknd 5844 20 order order NN cord-010119-t1x9gknd 5844 21 placement placement NN cord-010119-t1x9gknd 5844 22 . . . cord-010119-t1x9gknd 5845 1 In in IN cord-010119-t1x9gknd 5845 2 2016 2016 CD cord-010119-t1x9gknd 5845 3 , , , cord-010119-t1x9gknd 5845 4 3105 3105 CD cord-010119-t1x9gknd 5845 5 FFP FFP NNP cord-010119-t1x9gknd 5845 6 orders order NNS cord-010119-t1x9gknd 5845 7 occurred occur VBD cord-010119-t1x9gknd 5845 8 and and CC cord-010119-t1x9gknd 5845 9 the the DT cord-010119-t1x9gknd 5845 10 top top JJ cord-010119-t1x9gknd 5845 11 three three CD cord-010119-t1x9gknd 5845 12 patient patient JJ cord-010119-t1x9gknd 5845 13 groups group NNS cord-010119-t1x9gknd 5845 14 were be VBD cord-010119-t1x9gknd 5845 15 : : : cord-010119-t1x9gknd 5845 16 46 46 CD cord-010119-t1x9gknd 5845 17 % % NN cord-010119-t1x9gknd 5845 18 in in IN cord-010119-t1x9gknd 5845 19 neonates neonate NNS cord-010119-t1x9gknd 5845 20 in in IN cord-010119-t1x9gknd 5845 21 the the DT cord-010119-t1x9gknd 5845 22 NICU NICU NNP cord-010119-t1x9gknd 5845 23 , , , cord-010119-t1x9gknd 5845 24 28 28 CD cord-010119-t1x9gknd 5845 25 % % NN cord-010119-t1x9gknd 5845 26 in in IN cord-010119-t1x9gknd 5845 27 congenital congenital JJ cord-010119-t1x9gknd 5845 28 heart heart NN cord-010119-t1x9gknd 5845 29 disease disease NN cord-010119-t1x9gknd 5845 30 patients patient NNS cord-010119-t1x9gknd 5845 31 and and CC cord-010119-t1x9gknd 5845 32 13 13 CD cord-010119-t1x9gknd 5845 33 % % NN cord-010119-t1x9gknd 5845 34 in in IN cord-010119-t1x9gknd 5845 35 pediatric pediatric JJ cord-010119-t1x9gknd 5845 36 intensive intensive JJ cord-010119-t1x9gknd 5845 37 care care NN cord-010119-t1x9gknd 5845 38 patients patient NNS cord-010119-t1x9gknd 5845 39 . . . cord-010119-t1x9gknd 5846 1 Average average JJ cord-010119-t1x9gknd 5846 2 INR INR NNP cord-010119-t1x9gknd 5846 3 of of IN cord-010119-t1x9gknd 5846 4 every every DT cord-010119-t1x9gknd 5846 5 patient patient NN cord-010119-t1x9gknd 5846 6 was be VBD cord-010119-t1x9gknd 5846 7 2.09 2.09 CD cord-010119-t1x9gknd 5846 8 as as IN cord-010119-t1x9gknd 5846 9 measured measure VBN cord-010119-t1x9gknd 5846 10 in in IN cord-010119-t1x9gknd 5846 11 the the DT cord-010119-t1x9gknd 5846 12 72 72 CD cord-010119-t1x9gknd 5846 13 hours hour NNS cord-010119-t1x9gknd 5846 14 prior prior RB cord-010119-t1x9gknd 5846 15 to to IN cord-010119-t1x9gknd 5846 16 FFP ffp NN cord-010119-t1x9gknd 5846 17 order order NN cord-010119-t1x9gknd 5846 18 placement placement NN cord-010119-t1x9gknd 5846 19 . . . cord-010119-t1x9gknd 5847 1 Conclusion conclusion NN cord-010119-t1x9gknd 5847 2 : : : cord-010119-t1x9gknd 5847 3 We -PRON- PRP cord-010119-t1x9gknd 5847 4 have have VBP cord-010119-t1x9gknd 5847 5 designed design VBN cord-010119-t1x9gknd 5847 6 a a DT cord-010119-t1x9gknd 5847 7 robust robust JJ cord-010119-t1x9gknd 5847 8 data data NN cord-010119-t1x9gknd 5847 9 base base NN cord-010119-t1x9gknd 5847 10 that that WDT cord-010119-t1x9gknd 5847 11 is be VBZ cord-010119-t1x9gknd 5847 12 continually continually RB cord-010119-t1x9gknd 5847 13 updated update VBN cord-010119-t1x9gknd 5847 14 for for IN cord-010119-t1x9gknd 5847 15 children child NNS cord-010119-t1x9gknd 5847 16 in in IN cord-010119-t1x9gknd 5847 17 a a DT cord-010119-t1x9gknd 5847 18 large large JJ cord-010119-t1x9gknd 5847 19 , , , cord-010119-t1x9gknd 5847 20 tertiary tertiary JJ cord-010119-t1x9gknd 5847 21 care care NN cord-010119-t1x9gknd 5847 22 academic academic JJ cord-010119-t1x9gknd 5847 23 children child NNS cord-010119-t1x9gknd 5847 24 's 's POS cord-010119-t1x9gknd 5847 25 hospital hospital NN cord-010119-t1x9gknd 5847 26 . . . cord-010119-t1x9gknd 5848 1 This this DT cord-010119-t1x9gknd 5848 2 serves serve VBZ cord-010119-t1x9gknd 5848 3 as as IN cord-010119-t1x9gknd 5848 4 an an DT cord-010119-t1x9gknd 5848 5 important important JJ cord-010119-t1x9gknd 5848 6 benchmark benchmark NN cord-010119-t1x9gknd 5848 7 in in IN cord-010119-t1x9gknd 5848 8 pediatric pediatric JJ cord-010119-t1x9gknd 5848 9 blood blood NN cord-010119-t1x9gknd 5848 10 utilization utilization NN cord-010119-t1x9gknd 5848 11 , , , cord-010119-t1x9gknd 5848 12 and and CC cord-010119-t1x9gknd 5848 13 we -PRON- PRP cord-010119-t1x9gknd 5848 14 plan plan VBP cord-010119-t1x9gknd 5848 15 to to TO cord-010119-t1x9gknd 5848 16 leverage leverage VB cord-010119-t1x9gknd 5848 17 usage usage NN cord-010119-t1x9gknd 5848 18 patterns pattern NNS cord-010119-t1x9gknd 5848 19 to to TO cord-010119-t1x9gknd 5848 20 make make VB cord-010119-t1x9gknd 5848 21 relevant relevant JJ cord-010119-t1x9gknd 5848 22 practice practice NN cord-010119-t1x9gknd 5848 23 changes change NNS cord-010119-t1x9gknd 5848 24 in in IN cord-010119-t1x9gknd 5848 25 the the DT cord-010119-t1x9gknd 5848 26 care care NN cord-010119-t1x9gknd 5848 27 of of IN cord-010119-t1x9gknd 5848 28 children child NNS cord-010119-t1x9gknd 5848 29 with with IN cord-010119-t1x9gknd 5848 30 a a DT cord-010119-t1x9gknd 5848 31 heterogeneous heterogeneous JJ cord-010119-t1x9gknd 5848 32 set set NN cord-010119-t1x9gknd 5848 33 of of IN cord-010119-t1x9gknd 5848 34 illnesses illness NNS cord-010119-t1x9gknd 5848 35 . . . cord-010119-t1x9gknd 5849 1 Background Background NNP cord-010119-t1x9gknd 5849 2 / / SYM cord-010119-t1x9gknd 5849 3 Case Case NNP cord-010119-t1x9gknd 5849 4 Studies Studies NNPS cord-010119-t1x9gknd 5850 1 : : : cord-010119-t1x9gknd 5850 2 Bacterial bacterial JJ cord-010119-t1x9gknd 5850 3 contamination contamination NN cord-010119-t1x9gknd 5850 4 of of IN cord-010119-t1x9gknd 5850 5 PLTs plt NNS cord-010119-t1x9gknd 5850 6 remains remain VBZ cord-010119-t1x9gknd 5850 7 an an DT cord-010119-t1x9gknd 5850 8 ongoing ongoing JJ cord-010119-t1x9gknd 5850 9 threat threat NN cord-010119-t1x9gknd 5850 10 to to IN cord-010119-t1x9gknd 5850 11 transfusion transfusion NN cord-010119-t1x9gknd 5850 12 recipients recipient NNS cord-010119-t1x9gknd 5850 13 . . . cord-010119-t1x9gknd 5851 1 Recently recently RB cord-010119-t1x9gknd 5851 2 , , , cord-010119-t1x9gknd 5851 3 a a DT cord-010119-t1x9gknd 5851 4 psoralen psoralen NN cord-010119-t1x9gknd 5851 5 - - HYPH cord-010119-t1x9gknd 5851 6 based base VBN cord-010119-t1x9gknd 5851 7 PR pr NN cord-010119-t1x9gknd 5851 8 technology technology NN cord-010119-t1x9gknd 5851 9 that that WDT cord-010119-t1x9gknd 5851 10 reduces reduce VBZ cord-010119-t1x9gknd 5851 11 the the DT cord-010119-t1x9gknd 5851 12 replication replication NN cord-010119-t1x9gknd 5851 13 potential potential NN cord-010119-t1x9gknd 5851 14 of of IN cord-010119-t1x9gknd 5851 15 pathogens pathogen NNS cord-010119-t1x9gknd 5851 16 in in IN cord-010119-t1x9gknd 5851 17 stored store VBN cord-010119-t1x9gknd 5851 18 PLTs plt NNS cord-010119-t1x9gknd 5851 19 was be VBD cord-010119-t1x9gknd 5851 20 FDA FDA NNP cord-010119-t1x9gknd 5851 21 approved approve VBN cord-010119-t1x9gknd 5851 22 . . . cord-010119-t1x9gknd 5852 1 We -PRON- PRP cord-010119-t1x9gknd 5852 2 describe describe VBP cord-010119-t1x9gknd 5852 3 our -PRON- PRP$ cord-010119-t1x9gknd 5852 4 approach approach NN cord-010119-t1x9gknd 5852 5 to to IN cord-010119-t1x9gknd 5852 6 phasing phase VBG cord-010119-t1x9gknd 5852 7 PR PR NNP cord-010119-t1x9gknd 5852 8 - - HYPH cord-010119-t1x9gknd 5852 9 PLTs plt NNS cord-010119-t1x9gknd 5852 10 into into IN cord-010119-t1x9gknd 5852 11 our -PRON- PRP$ cord-010119-t1x9gknd 5852 12 inventory inventory NN cord-010119-t1x9gknd 5852 13 , , , cord-010119-t1x9gknd 5852 14 including include VBG cord-010119-t1x9gknd 5852 15 preliminary preliminary JJ cord-010119-t1x9gknd 5852 16 results result NNS cord-010119-t1x9gknd 5852 17 of of IN cord-010119-t1x9gknd 5852 18 an an DT cord-010119-t1x9gknd 5852 19 ongoing ongoing JJ cord-010119-t1x9gknd 5852 20 QA QA NNP cord-010119-t1x9gknd 5852 21 study study NN cord-010119-t1x9gknd 5852 22 of of IN cord-010119-t1x9gknd 5852 23 neonatal neonatal JJ cord-010119-t1x9gknd 5852 24 and and CC cord-010119-t1x9gknd 5852 25 pediatric pediatric JJ cord-010119-t1x9gknd 5852 26 ( ( -LRB- cord-010119-t1x9gknd 5852 27 PEDS PEDS NNP cord-010119-t1x9gknd 5852 28 ) ) -RRB- cord-010119-t1x9gknd 5852 29 recipients recipient NNS cord-010119-t1x9gknd 5852 30 of of IN cord-010119-t1x9gknd 5852 31 PR PR NNP cord-010119-t1x9gknd 5852 32 - - HYPH cord-010119-t1x9gknd 5852 33 PLTs PLTs NNP cord-010119-t1x9gknd 5852 34 . . . cord-010119-t1x9gknd 5853 1 Study Study NNP cord-010119-t1x9gknd 5853 2 Design Design NNP cord-010119-t1x9gknd 5853 3 / / SYM cord-010119-t1x9gknd 5853 4 Methods method NNS cord-010119-t1x9gknd 5853 5 : : : cord-010119-t1x9gknd 5853 6 Before before IN cord-010119-t1x9gknd 5853 7 the the DT cord-010119-t1x9gknd 5853 8 arrival arrival NN cord-010119-t1x9gknd 5853 9 of of IN cord-010119-t1x9gknd 5853 10 PR PR NNP cord-010119-t1x9gknd 5853 11 - - HYPH cord-010119-t1x9gknd 5853 12 PLT PLT NNP cord-010119-t1x9gknd 5853 13 , , , cord-010119-t1x9gknd 5853 14 we -PRON- PRP cord-010119-t1x9gknd 5853 15 undertook undertake VBD cord-010119-t1x9gknd 5853 16 an an DT cord-010119-t1x9gknd 5853 17 educational educational JJ cord-010119-t1x9gknd 5853 18 campaign campaign NN cord-010119-t1x9gknd 5853 19 for for IN cord-010119-t1x9gknd 5853 20 hospital hospital NN cord-010119-t1x9gknd 5853 21 administrators administrator NNS cord-010119-t1x9gknd 5853 22 , , , cord-010119-t1x9gknd 5853 23 IT IT NNP cord-010119-t1x9gknd 5853 24 staff staff NN cord-010119-t1x9gknd 5853 25 , , , cord-010119-t1x9gknd 5853 26 laboratory laboratory NN cord-010119-t1x9gknd 5853 27 staff staff NN cord-010119-t1x9gknd 5853 28 , , , cord-010119-t1x9gknd 5853 29 clerical clerical JJ cord-010119-t1x9gknd 5853 30 / / SYM cord-010119-t1x9gknd 5853 31 clinical clinical JJ cord-010119-t1x9gknd 5853 32 aides aide NNS cord-010119-t1x9gknd 5853 33 , , , cord-010119-t1x9gknd 5853 34 nurses nurse NNS cord-010119-t1x9gknd 5853 35 , , , cord-010119-t1x9gknd 5853 36 and and CC cord-010119-t1x9gknd 5853 37 physicians physician NNS cord-010119-t1x9gknd 5853 38 . . . cord-010119-t1x9gknd 5854 1 We -PRON- PRP cord-010119-t1x9gknd 5854 2 also also RB cord-010119-t1x9gknd 5854 3 contacted contact VBD cord-010119-t1x9gknd 5854 4 risk risk NN cord-010119-t1x9gknd 5854 5 management management NN cord-010119-t1x9gknd 5854 6 and and CC cord-010119-t1x9gknd 5854 7 the the DT cord-010119-t1x9gknd 5854 8 hospital hospital NN cord-010119-t1x9gknd 5854 9 ethics ethic NNS cord-010119-t1x9gknd 5854 10 committee committee NNP cord-010119-t1x9gknd 5854 11 . . . cord-010119-t1x9gknd 5855 1 Phototherapy Phototherapy NNP cord-010119-t1x9gknd 5855 2 devices device NNS cord-010119-t1x9gknd 5855 3 used use VBN cord-010119-t1x9gknd 5855 4 at at IN cord-010119-t1x9gknd 5855 5 our -PRON- PRP$ cord-010119-t1x9gknd 5855 6 hospital hospital NN cord-010119-t1x9gknd 5855 7 were be VBD cord-010119-t1x9gknd 5855 8 confirmed confirm VBN cord-010119-t1x9gknd 5855 9 to to TO cord-010119-t1x9gknd 5855 10 be be VB cord-010119-t1x9gknd 5855 11 compatible compatible JJ cord-010119-t1x9gknd 5855 12 with with IN cord-010119-t1x9gknd 5855 13 the the DT cord-010119-t1x9gknd 5855 14 psoralen psoralen NN cord-010119-t1x9gknd 5855 15 - - HYPH cord-010119-t1x9gknd 5855 16 based base VBN cord-010119-t1x9gknd 5855 17 PR PR NNP cord-010119-t1x9gknd 5855 18 - - HYPH cord-010119-t1x9gknd 5855 19 PLT PLT NNP cord-010119-t1x9gknd 5855 20 product product NN cord-010119-t1x9gknd 5855 21 . . . cord-010119-t1x9gknd 5856 1 Shortly shortly RB cord-010119-t1x9gknd 5856 2 following follow VBG cord-010119-t1x9gknd 5856 3 the the DT cord-010119-t1x9gknd 5856 4 arrival arrival NN cord-010119-t1x9gknd 5856 5 of of IN cord-010119-t1x9gknd 5856 6 PR PR NNP cord-010119-t1x9gknd 5856 7 - - HYPH cord-010119-t1x9gknd 5856 8 PLT PLT NNP cord-010119-t1x9gknd 5856 9 , , , cord-010119-t1x9gknd 5856 10 we -PRON- PRP cord-010119-t1x9gknd 5856 11 introduced introduce VBD cord-010119-t1x9gknd 5856 12 day day NN cord-010119-t1x9gknd 5856 13 5 5 CD cord-010119-t1x9gknd 5856 14 bacterial bacterial JJ cord-010119-t1x9gknd 5856 15 " " `` cord-010119-t1x9gknd 5856 16 safety safety NN cord-010119-t1x9gknd 5856 17 measure measure NN cord-010119-t1x9gknd 5856 18 " " '' cord-010119-t1x9gknd 5856 19 testing testing NN cord-010119-t1x9gknd 5856 20 of of IN cord-010119-t1x9gknd 5856 21 our -PRON- PRP$ cord-010119-t1x9gknd 5856 22 conventional conventional JJ cord-010119-t1x9gknd 5856 23 ( ( -LRB- cord-010119-t1x9gknd 5856 24 C C NNP cord-010119-t1x9gknd 5856 25 - - HYPH cord-010119-t1x9gknd 5856 26 PLT PLT NNP cord-010119-t1x9gknd 5856 27 ) ) -RRB- cord-010119-t1x9gknd 5856 28 supply supply NN cord-010119-t1x9gknd 5856 29 . . . cord-010119-t1x9gknd 5857 1 A a DT cord-010119-t1x9gknd 5857 2 PEDS PEDS NNP cord-010119-t1x9gknd 5857 3 QA QA NNP cord-010119-t1x9gknd 5857 4 study study NN cord-010119-t1x9gknd 5857 5 monitored monitor VBD cord-010119-t1x9gknd 5857 6 PLT PLT NNP cord-010119-t1x9gknd 5857 7 utilization utilization NN cord-010119-t1x9gknd 5857 8 and and CC cord-010119-t1x9gknd 5857 9 adverse adverse JJ cord-010119-t1x9gknd 5857 10 transfusion transfusion NN cord-010119-t1x9gknd 5857 11 event event NN cord-010119-t1x9gknd 5857 12 reporting report VBG cord-010119-t1x9gknd 5857 13 relating relate VBG cord-010119-t1x9gknd 5857 14 to to IN cord-010119-t1x9gknd 5857 15 both both DT cord-010119-t1x9gknd 5857 16 PR PR NNP cord-010119-t1x9gknd 5857 17 - - : cord-010119-t1x9gknd 5857 18 and and CC cord-010119-t1x9gknd 5857 19 C C NNP cord-010119-t1x9gknd 5857 20 - - HYPH cord-010119-t1x9gknd 5857 21 PLT PLT NNP cord-010119-t1x9gknd 5857 22 transfusions transfusion NNS cord-010119-t1x9gknd 5857 23 . . . cord-010119-t1x9gknd 5858 1 This this DT cord-010119-t1x9gknd 5858 2 study study NN cord-010119-t1x9gknd 5858 3 evaluated evaluate VBD cord-010119-t1x9gknd 5858 4 neonates neonate NNS cord-010119-t1x9gknd 5858 5 ( ( -LRB- cord-010119-t1x9gknd 5858 6 0 0 CD cord-010119-t1x9gknd 5858 7 - - SYM cord-010119-t1x9gknd 5858 8 4 4 CD cord-010119-t1x9gknd 5858 9 months month NNS cord-010119-t1x9gknd 5858 10 of of IN cord-010119-t1x9gknd 5858 11 age age NN cord-010119-t1x9gknd 5858 12 ) ) -RRB- cord-010119-t1x9gknd 5858 13 , , , cord-010119-t1x9gknd 5858 14 infants infant NNS cord-010119-t1x9gknd 5858 15 ( ( -LRB- cord-010119-t1x9gknd 5858 16 > > NFP cord-010119-t1x9gknd 5858 17 4 4 CD cord-010119-t1x9gknd 5858 18 - - SYM cord-010119-t1x9gknd 5858 19 12 12 CD cord-010119-t1x9gknd 5858 20 months month NNS cord-010119-t1x9gknd 5858 21 of of IN cord-010119-t1x9gknd 5858 22 age age NN cord-010119-t1x9gknd 5858 23 ) ) -RRB- cord-010119-t1x9gknd 5858 24 and and CC cord-010119-t1x9gknd 5858 25 children child NNS cord-010119-t1x9gknd 5858 26 ( ( -LRB- cord-010119-t1x9gknd 5858 27 > > NFP cord-010119-t1x9gknd 5858 28 12 12 CD cord-010119-t1x9gknd 5858 29 months-18 months-18 CD cord-010119-t1x9gknd 5858 30 years year NNS cord-010119-t1x9gknd 5858 31 of of IN cord-010119-t1x9gknd 5858 32 age age NN cord-010119-t1x9gknd 5858 33 ) ) -RRB- cord-010119-t1x9gknd 5858 34 who who WP cord-010119-t1x9gknd 5858 35 received receive VBD cord-010119-t1x9gknd 5858 36 at at IN cord-010119-t1x9gknd 5858 37 least least RBS cord-010119-t1x9gknd 5858 38 one one CD cord-010119-t1x9gknd 5858 39 transfusion transfusion NN cord-010119-t1x9gknd 5858 40 of of IN cord-010119-t1x9gknd 5858 41 PR PR NNP cord-010119-t1x9gknd 5858 42 - - HYPH cord-010119-t1x9gknd 5858 43 PLTs PLTs NNP cord-010119-t1x9gknd 5858 44 . . . cord-010119-t1x9gknd 5859 1 Results result NNS cord-010119-t1x9gknd 5859 2 / / SYM cord-010119-t1x9gknd 5859 3 Findings finding NNS cord-010119-t1x9gknd 5859 4 : : : cord-010119-t1x9gknd 5860 1 Risk risk NN cord-010119-t1x9gknd 5860 2 management management NN cord-010119-t1x9gknd 5860 3 and and CC cord-010119-t1x9gknd 5860 4 the the DT cord-010119-t1x9gknd 5860 5 ethics ethic NNS cord-010119-t1x9gknd 5860 6 committee committee NNP cord-010119-t1x9gknd 5860 7 agreed agree VBD cord-010119-t1x9gknd 5860 8 that that IN cord-010119-t1x9gknd 5860 9 both both DT cord-010119-t1x9gknd 5860 10 PR PR NNP cord-010119-t1x9gknd 5860 11 - - HYPH cord-010119-t1x9gknd 5860 12 PLTs plt NNS cord-010119-t1x9gknd 5860 13 and and CC cord-010119-t1x9gknd 5860 14 bacteria bacteria NNS cord-010119-t1x9gknd 5860 15 tested test VBD cord-010119-t1x9gknd 5860 16 C C NNP cord-010119-t1x9gknd 5860 17 - - HYPH cord-010119-t1x9gknd 5860 18 PLTs PLTs NNP cord-010119-t1x9gknd 5860 19 would would MD cord-010119-t1x9gknd 5860 20 be be VB cord-010119-t1x9gknd 5860 21 the the DT cord-010119-t1x9gknd 5860 22 hospital hospital NN cord-010119-t1x9gknd 5860 23 standard standard NN cord-010119-t1x9gknd 5860 24 of of IN cord-010119-t1x9gknd 5860 25 care care NN cord-010119-t1x9gknd 5860 26 . . . cord-010119-t1x9gknd 5861 1 PR PR NNP cord-010119-t1x9gknd 5861 2 - - HYPH cord-010119-t1x9gknd 5861 3 PLTs PLTs NNP cord-010119-t1x9gknd 5861 4 were be VBD cord-010119-t1x9gknd 5861 5 phased phase VBN cord-010119-t1x9gknd 5861 6 in in IN cord-010119-t1x9gknd 5861 7 and and CC cord-010119-t1x9gknd 5861 8 transfused transfuse VBN cord-010119-t1x9gknd 5861 9 to to IN cord-010119-t1x9gknd 5861 10 patients patient NNS cord-010119-t1x9gknd 5861 11 based base VBN cord-010119-t1x9gknd 5861 12 on on IN cord-010119-t1x9gknd 5861 13 ABO ABO NNP cord-010119-t1x9gknd 5861 14 compatibility compatibility NN cord-010119-t1x9gknd 5861 15 and and CC cord-010119-t1x9gknd 5861 16 expiration expiration NN cord-010119-t1x9gknd 5861 17 date date NN cord-010119-t1x9gknd 5861 18 , , , cord-010119-t1x9gknd 5861 19 per per IN cord-010119-t1x9gknd 5861 20 routine routine NN cord-010119-t1x9gknd 5861 21 , , , cord-010119-t1x9gknd 5861 22 without without IN cord-010119-t1x9gknd 5861 23 regard regard NN cord-010119-t1x9gknd 5861 24 for for IN cord-010119-t1x9gknd 5861 25 patient patient JJ cord-010119-t1x9gknd 5861 26 age age NN cord-010119-t1x9gknd 5861 27 or or CC cord-010119-t1x9gknd 5861 28 medical medical JJ cord-010119-t1x9gknd 5861 29 condition condition NN cord-010119-t1x9gknd 5861 30 . . . cord-010119-t1x9gknd 5862 1 After after IN cord-010119-t1x9gknd 5862 2 4 4 CD cord-010119-t1x9gknd 5862 3 months month NNS cord-010119-t1x9gknd 5862 4 , , , cord-010119-t1x9gknd 5862 5 PR PR NNP cord-010119-t1x9gknd 5862 6 - - HYPH cord-010119-t1x9gknd 5862 7 PLT PLT NNP cord-010119-t1x9gknd 5862 8 represented represent VBD cord-010119-t1x9gknd 5862 9 30 30 CD cord-010119-t1x9gknd 5862 10 % % NN cord-010119-t1x9gknd 5862 11 of of IN cord-010119-t1x9gknd 5862 12 our -PRON- PRP$ cord-010119-t1x9gknd 5862 13 platelet platelet NN cord-010119-t1x9gknd 5862 14 inventory inventory NN cord-010119-t1x9gknd 5862 15 ( ( -LRB- cord-010119-t1x9gknd 5862 16 average average JJ cord-010119-t1x9gknd 5862 17 daily daily JJ cord-010119-t1x9gknd 5862 18 PLT PLT NNP cord-010119-t1x9gknd 5862 19 inventory inventory NN cord-010119-t1x9gknd 5862 20 : : : cord-010119-t1x9gknd 5862 21 45 45 CD cord-010119-t1x9gknd 5862 22 units unit NNS cord-010119-t1x9gknd 5862 23 ) ) -RRB- cord-010119-t1x9gknd 5862 24 . . . cord-010119-t1x9gknd 5863 1 We -PRON- PRP cord-010119-t1x9gknd 5863 2 encountered encounter VBD cord-010119-t1x9gknd 5863 3 no no DT cord-010119-t1x9gknd 5863 4 complications complication NNS cord-010119-t1x9gknd 5863 5 with with IN cord-010119-t1x9gknd 5863 6 the the DT cord-010119-t1x9gknd 5863 7 PR PR NNP cord-010119-t1x9gknd 5863 8 platelet platelet NN cord-010119-t1x9gknd 5863 9 phase phase NN cord-010119-t1x9gknd 5863 10 - - HYPH cord-010119-t1x9gknd 5863 11 in in RP cord-010119-t1x9gknd 5863 12 , , , cord-010119-t1x9gknd 5863 13 either either CC cord-010119-t1x9gknd 5863 14 from from IN cord-010119-t1x9gknd 5863 15 a a DT cord-010119-t1x9gknd 5863 16 clinical clinical JJ cord-010119-t1x9gknd 5863 17 , , , cord-010119-t1x9gknd 5863 18 informatics informatic NNS cord-010119-t1x9gknd 5863 19 or or CC cord-010119-t1x9gknd 5863 20 logistical logistical JJ cord-010119-t1x9gknd 5863 21 perspective perspective NN cord-010119-t1x9gknd 5863 22 . . . cord-010119-t1x9gknd 5864 1 Due due IN cord-010119-t1x9gknd 5864 2 to to IN cord-010119-t1x9gknd 5864 3 the the DT cord-010119-t1x9gknd 5864 4 dual dual JJ cord-010119-t1x9gknd 5864 5 inventory inventory NN cord-010119-t1x9gknd 5864 6 , , , cord-010119-t1x9gknd 5864 7 many many JJ cord-010119-t1x9gknd 5864 8 PEDS PEDS NNP cord-010119-t1x9gknd 5864 9 patients patient NNS cord-010119-t1x9gknd 5864 10 in in IN cord-010119-t1x9gknd 5864 11 all all DT cord-010119-t1x9gknd 5864 12 age age NN cord-010119-t1x9gknd 5864 13 groups group NNS cord-010119-t1x9gknd 5864 14 were be VBD cord-010119-t1x9gknd 5864 15 transfused transfuse VBN cord-010119-t1x9gknd 5864 16 with with IN cord-010119-t1x9gknd 5864 17 both both DT cord-010119-t1x9gknd 5864 18 PR pr NN cord-010119-t1x9gknd 5864 19 - - : cord-010119-t1x9gknd 5864 20 and and CC cord-010119-t1x9gknd 5864 21 C C NNP cord-010119-t1x9gknd 5864 22 - - HYPH cord-010119-t1x9gknd 5864 23 PLTs PLTs NNP cord-010119-t1x9gknd 5864 24 ( ( -LRB- cord-010119-t1x9gknd 5864 25 Table table NN cord-010119-t1x9gknd 5864 26 ) ) -RRB- cord-010119-t1x9gknd 5864 27 . . . cord-010119-t1x9gknd 5865 1 Two two CD cord-010119-t1x9gknd 5865 2 potential potential JJ cord-010119-t1x9gknd 5865 3 transfusion transfusion NN cord-010119-t1x9gknd 5865 4 reactions reaction NNS cord-010119-t1x9gknd 5865 5 ( ( -LRB- cord-010119-t1x9gknd 5865 6 TRs tr NNS cord-010119-t1x9gknd 5865 7 ) ) -RRB- cord-010119-t1x9gknd 5865 8 were be VBD cord-010119-t1x9gknd 5865 9 reported report VBN cord-010119-t1x9gknd 5865 10 over over IN cord-010119-t1x9gknd 5865 11 the the DT cord-010119-t1x9gknd 5865 12 study study NN cord-010119-t1x9gknd 5865 13 period period NN cord-010119-t1x9gknd 5865 14 in in IN cord-010119-t1x9gknd 5865 15 teenage teenage JJ cord-010119-t1x9gknd 5865 16 recipients recipient NNS cord-010119-t1x9gknd 5865 17 , , , cord-010119-t1x9gknd 5865 18 one one CD cord-010119-t1x9gknd 5865 19 associated associate VBN cord-010119-t1x9gknd 5865 20 with with IN cord-010119-t1x9gknd 5865 21 a a DT cord-010119-t1x9gknd 5865 22 C C NNP cord-010119-t1x9gknd 5865 23 - - HYPH cord-010119-t1x9gknd 5865 24 PLT PLT NNP cord-010119-t1x9gknd 5865 25 and and CC cord-010119-t1x9gknd 5865 26 the the DT cord-010119-t1x9gknd 5865 27 other other JJ cord-010119-t1x9gknd 5865 28 with with IN cord-010119-t1x9gknd 5865 29 a a DT cord-010119-t1x9gknd 5865 30 PR PR NNP cord-010119-t1x9gknd 5865 31 - - HYPH cord-010119-t1x9gknd 5865 32 PLT PLT NNP cord-010119-t1x9gknd 5865 33 . . . cord-010119-t1x9gknd 5866 1 In in IN cord-010119-t1x9gknd 5866 2 both both DT cord-010119-t1x9gknd 5866 3 cases case NNS cord-010119-t1x9gknd 5866 4 , , , cord-010119-t1x9gknd 5866 5 the the DT cord-010119-t1x9gknd 5866 6 symptoms symptom NNS cord-010119-t1x9gknd 5866 7 were be VBD cord-010119-t1x9gknd 5866 8 ultimately ultimately RB cord-010119-t1x9gknd 5866 9 attributed attribute VBN cord-010119-t1x9gknd 5866 10 to to IN cord-010119-t1x9gknd 5866 11 an an DT cord-010119-t1x9gknd 5866 12 underlying underlying JJ cord-010119-t1x9gknd 5866 13 medical medical JJ cord-010119-t1x9gknd 5866 14 condition condition NN cord-010119-t1x9gknd 5866 15 . . . cord-010119-t1x9gknd 5867 1 No no DT cord-010119-t1x9gknd 5867 2 rashes rash NNS cord-010119-t1x9gknd 5867 3 were be VBD cord-010119-t1x9gknd 5867 4 observed observe VBN cord-010119-t1x9gknd 5867 5 among among IN cord-010119-t1x9gknd 5867 6 16 16 CD cord-010119-t1x9gknd 5867 7 transfused transfuse VBN cord-010119-t1x9gknd 5867 8 neonates neonate NNS cord-010119-t1x9gknd 5867 9 ( ( -LRB- cord-010119-t1x9gknd 5867 10 0 0 CD cord-010119-t1x9gknd 5867 11 - - SYM cord-010119-t1x9gknd 5867 12 4 4 CD cord-010119-t1x9gknd 5867 13 m m CD cord-010119-t1x9gknd 5867 14 ) ) -RRB- cord-010119-t1x9gknd 5867 15 who who WP cord-010119-t1x9gknd 5867 16 received receive VBD cord-010119-t1x9gknd 5867 17 any any DT cord-010119-t1x9gknd 5867 18 PR PR NNP cord-010119-t1x9gknd 5867 19 - - HYPH cord-010119-t1x9gknd 5867 20 PLTs plt NNS cord-010119-t1x9gknd 5867 21 and and CC cord-010119-t1x9gknd 5867 22 phototherapy phototherapy NN cord-010119-t1x9gknd 5867 23 . . . cord-010119-t1x9gknd 5868 1 Background Background NNP cord-010119-t1x9gknd 5868 2 / / SYM cord-010119-t1x9gknd 5868 3 Case Case NNP cord-010119-t1x9gknd 5868 4 Studies Studies NNPS cord-010119-t1x9gknd 5868 5 : : : cord-010119-t1x9gknd 5868 6 Packed packed JJ cord-010119-t1x9gknd 5868 7 red red JJ cord-010119-t1x9gknd 5868 8 blood blood NN cord-010119-t1x9gknd 5868 9 cell cell NN cord-010119-t1x9gknd 5868 10 ( ( -LRB- cord-010119-t1x9gknd 5868 11 PRBC PRBC NNP cord-010119-t1x9gknd 5868 12 ) ) -RRB- cord-010119-t1x9gknd 5869 1 transfusions transfusion NNS cord-010119-t1x9gknd 5869 2 are be VBP cord-010119-t1x9gknd 5869 3 believed believe VBN cord-010119-t1x9gknd 5869 4 to to TO cord-010119-t1x9gknd 5869 5 improve improve VB cord-010119-t1x9gknd 5869 6 oxygen oxygen NN cord-010119-t1x9gknd 5869 7 delivery delivery NN cord-010119-t1x9gknd 5869 8 particularly particularly RB cord-010119-t1x9gknd 5869 9 in in IN cord-010119-t1x9gknd 5869 10 vulnerable vulnerable JJ cord-010119-t1x9gknd 5869 11 patients patient NNS cord-010119-t1x9gknd 5869 12 such such JJ cord-010119-t1x9gknd 5869 13 as as IN cord-010119-t1x9gknd 5869 14 neonates neonate NNS cord-010119-t1x9gknd 5869 15 and and CC cord-010119-t1x9gknd 5869 16 children child NNS cord-010119-t1x9gknd 5869 17 . . . cord-010119-t1x9gknd 5870 1 However however RB cord-010119-t1x9gknd 5870 2 , , , cord-010119-t1x9gknd 5870 3 evidence evidence NN cord-010119-t1x9gknd 5870 4 shows show VBZ cord-010119-t1x9gknd 5870 5 that that IN cord-010119-t1x9gknd 5870 6 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5870 7 ( ( -LRB- cord-010119-t1x9gknd 5870 8 Hgb Hgb NNP cord-010119-t1x9gknd 5870 9 ) ) -RRB- cord-010119-t1x9gknd 5870 10 in in IN cord-010119-t1x9gknd 5870 11 PRBCs prbc NNS cord-010119-t1x9gknd 5870 12 has have VBZ cord-010119-t1x9gknd 5870 13 increased increase VBN cord-010119-t1x9gknd 5870 14 oxygen oxygen NN cord-010119-t1x9gknd 5870 15 affinity affinity NN cord-010119-t1x9gknd 5870 16 and and CC cord-010119-t1x9gknd 5870 17 thus thus RB cord-010119-t1x9gknd 5870 18 reduced reduce VBN cord-010119-t1x9gknd 5870 19 oxygen oxygen NN cord-010119-t1x9gknd 5870 20 delivery delivery NN cord-010119-t1x9gknd 5870 21 to to IN cord-010119-t1x9gknd 5870 22 tissues tissue NNS cord-010119-t1x9gknd 5870 23 due due JJ cord-010119-t1x9gknd 5870 24 to to IN cord-010119-t1x9gknd 5870 25 decreased decrease VBD cord-010119-t1x9gknd 5870 26 2,3 2,3 CD cord-010119-t1x9gknd 5870 27 DPG DPG NNP cord-010119-t1x9gknd 5870 28 levels level NNS cord-010119-t1x9gknd 5870 29 . . . cord-010119-t1x9gknd 5871 1 Standardization standardization NN cord-010119-t1x9gknd 5871 2 of of IN cord-010119-t1x9gknd 5871 3 PRBC PRBC NNP cord-010119-t1x9gknd 5871 4 transfusion transfusion NN cord-010119-t1x9gknd 5871 5 practices practice NNS cord-010119-t1x9gknd 5871 6 in in IN cord-010119-t1x9gknd 5871 7 this this DT cord-010119-t1x9gknd 5871 8 population population NN cord-010119-t1x9gknd 5871 9 and and CC cord-010119-t1x9gknd 5871 10 the the DT cord-010119-t1x9gknd 5871 11 scientific scientific JJ cord-010119-t1x9gknd 5871 12 evidence evidence NN cord-010119-t1x9gknd 5871 13 on on IN cord-010119-t1x9gknd 5871 14 which which WDT cord-010119-t1x9gknd 5871 15 current current JJ cord-010119-t1x9gknd 5871 16 practice practice NN cord-010119-t1x9gknd 5871 17 is be VBZ cord-010119-t1x9gknd 5871 18 based base VBN cord-010119-t1x9gknd 5871 19 is be VBZ cord-010119-t1x9gknd 5871 20 limited limit VBN cord-010119-t1x9gknd 5871 21 . . . cord-010119-t1x9gknd 5872 1 Additionally additionally RB cord-010119-t1x9gknd 5872 2 , , , cord-010119-t1x9gknd 5872 3 due due IN cord-010119-t1x9gknd 5872 4 to to IN cord-010119-t1x9gknd 5872 5 small small JJ cord-010119-t1x9gknd 5872 6 transfusion transfusion NN cord-010119-t1x9gknd 5872 7 volumes volume NNS cord-010119-t1x9gknd 5872 8 , , , cord-010119-t1x9gknd 5872 9 infants infant NNS cord-010119-t1x9gknd 5872 10 may may MD cord-010119-t1x9gknd 5872 11 be be VB cord-010119-t1x9gknd 5872 12 exposed expose VBN cord-010119-t1x9gknd 5872 13 to to IN cord-010119-t1x9gknd 5872 14 multiple multiple JJ cord-010119-t1x9gknd 5872 15 blood blood NN cord-010119-t1x9gknd 5872 16 donors donor NNS cord-010119-t1x9gknd 5872 17 , , , cord-010119-t1x9gknd 5872 18 increasing increase VBG cord-010119-t1x9gknd 5872 19 their -PRON- PRP$ cord-010119-t1x9gknd 5872 20 potential potential NN cord-010119-t1x9gknd 5872 21 for for IN cord-010119-t1x9gknd 5872 22 adverse adverse JJ cord-010119-t1x9gknd 5872 23 events event NNS cord-010119-t1x9gknd 5872 24 . . . cord-010119-t1x9gknd 5873 1 Study Study NNP cord-010119-t1x9gknd 5873 2 Design Design NNP cord-010119-t1x9gknd 5873 3 / / SYM cord-010119-t1x9gknd 5873 4 Method method NN cord-010119-t1x9gknd 5873 5 : : : cord-010119-t1x9gknd 5873 6 Medical medical JJ cord-010119-t1x9gknd 5873 7 records record NNS cord-010119-t1x9gknd 5873 8 of of IN cord-010119-t1x9gknd 5873 9 60 60 CD cord-010119-t1x9gknd 5873 10 pediatric pediatric JJ cord-010119-t1x9gknd 5873 11 patients patient NNS cord-010119-t1x9gknd 5873 12 receiving receive VBG cord-010119-t1x9gknd 5873 13 PRBC PRBC NNP cord-010119-t1x9gknd 5873 14 transfusion transfusion NN cord-010119-t1x9gknd 5873 15 over over IN cord-010119-t1x9gknd 5873 16 a a DT cord-010119-t1x9gknd 5873 17 12 12 CD cord-010119-t1x9gknd 5873 18 month month NN cord-010119-t1x9gknd 5873 19 period period NN cord-010119-t1x9gknd 5873 20 were be VBD cord-010119-t1x9gknd 5873 21 retrospectively retrospectively RB cord-010119-t1x9gknd 5873 22 reviewed review VBN cord-010119-t1x9gknd 5873 23 . . . cord-010119-t1x9gknd 5874 1 A a DT cord-010119-t1x9gknd 5874 2 total total NN cord-010119-t1x9gknd 5874 3 of of IN cord-010119-t1x9gknd 5874 4 44 44 CD cord-010119-t1x9gknd 5874 5 patients patient NNS cord-010119-t1x9gknd 5874 6 were be VBD cord-010119-t1x9gknd 5874 7 identified identify VBN cord-010119-t1x9gknd 5874 8 as as IN cord-010119-t1x9gknd 5874 9 receiving receive VBG cord-010119-t1x9gknd 5874 10 allogeneic allogeneic IN cord-010119-t1x9gknd 5874 11 PRBC PRBC NNP cord-010119-t1x9gknd 5874 12 transfusion transfusion NN cord-010119-t1x9gknd 5874 13 . . . cord-010119-t1x9gknd 5875 1 16 16 CD cord-010119-t1x9gknd 5875 2 patients patient NNS cord-010119-t1x9gknd 5875 3 who who WP cord-010119-t1x9gknd 5875 4 received receive VBD cord-010119-t1x9gknd 5875 5 autologous autologous JJ cord-010119-t1x9gknd 5875 6 blood blood NN cord-010119-t1x9gknd 5875 7 ( ( -LRB- cord-010119-t1x9gknd 5875 8 cell cell NN cord-010119-t1x9gknd 5875 9 salvage salvage NN cord-010119-t1x9gknd 5875 10 ) ) -RRB- cord-010119-t1x9gknd 5875 11 were be VBD cord-010119-t1x9gknd 5875 12 excluded exclude VBN cord-010119-t1x9gknd 5875 13 . . . cord-010119-t1x9gknd 5876 1 Patient patient JJ cord-010119-t1x9gknd 5876 2 characteristics characteristic NNS cord-010119-t1x9gknd 5876 3 , , , cord-010119-t1x9gknd 5876 4 length length NN cord-010119-t1x9gknd 5876 5 of of IN cord-010119-t1x9gknd 5876 6 stay stay NN cord-010119-t1x9gknd 5876 7 , , , cord-010119-t1x9gknd 5876 8 PRBC PRBC NNP cord-010119-t1x9gknd 5876 9 transfusion transfusion NN cord-010119-t1x9gknd 5876 10 volume volume NN cord-010119-t1x9gknd 5876 11 , , , cord-010119-t1x9gknd 5876 12 pre pre JJ cord-010119-t1x9gknd 5876 13 - - JJ cord-010119-t1x9gknd 5876 14 and and CC cord-010119-t1x9gknd 5876 15 post post JJ cord-010119-t1x9gknd 5876 16 - - JJ cord-010119-t1x9gknd 5876 17 transfusion transfusion NN cord-010119-t1x9gknd 5876 18 Hgb Hgb NNP cord-010119-t1x9gknd 5876 19 , , , cord-010119-t1x9gknd 5876 20 and and CC cord-010119-t1x9gknd 5876 21 adverse adverse JJ cord-010119-t1x9gknd 5876 22 events event NNS cord-010119-t1x9gknd 5876 23 were be VBD cord-010119-t1x9gknd 5876 24 collected collect VBN cord-010119-t1x9gknd 5876 25 . . . cord-010119-t1x9gknd 5877 1 Results/ Results/ . cord-010119-t1x9gknd 5878 1 Finding finding NN cord-010119-t1x9gknd 5878 2 : : : cord-010119-t1x9gknd 5879 1 The the DT cord-010119-t1x9gknd 5879 2 average average JJ cord-010119-t1x9gknd 5879 3 pre pre JJ cord-010119-t1x9gknd 5879 4 - - JJ cord-010119-t1x9gknd 5879 5 transfusion transfusion NN cord-010119-t1x9gknd 5879 6 Hgb Hgb NNP cord-010119-t1x9gknd 5879 7 was be VBD cord-010119-t1x9gknd 5879 8 10.6 10.6 CD cord-010119-t1x9gknd 5879 9 g g NN cord-010119-t1x9gknd 5879 10 / / SYM cord-010119-t1x9gknd 5879 11 dL dl NN cord-010119-t1x9gknd 5879 12 with with IN cord-010119-t1x9gknd 5879 13 post post JJ cord-010119-t1x9gknd 5879 14 - - JJ cord-010119-t1x9gknd 5879 15 transfusion transfusion NN cord-010119-t1x9gknd 5879 16 Hgb Hgb NNP cord-010119-t1x9gknd 5879 17 rising rise VBG cord-010119-t1x9gknd 5879 18 to to IN cord-010119-t1x9gknd 5879 19 14.5 14.5 CD cord-010119-t1x9gknd 5879 20 g g NN cord-010119-t1x9gknd 5879 21 / / SYM cord-010119-t1x9gknd 5879 22 dL. dl. NN cord-010119-t1x9gknd 5880 1 The the DT cord-010119-t1x9gknd 5880 2 mean mean JJ cord-010119-t1x9gknd 5880 3 PRBC PRBC NNP cord-010119-t1x9gknd 5880 4 volume volume NN cord-010119-t1x9gknd 5880 5 transfused transfuse VBN cord-010119-t1x9gknd 5880 6 was be VBD cord-010119-t1x9gknd 5880 7 46.3 46.3 CD cord-010119-t1x9gknd 5880 8 mL ml NN cord-010119-t1x9gknd 5880 9 using use VBG cord-010119-t1x9gknd 5880 10 a a DT cord-010119-t1x9gknd 5880 11 dose dose NN cord-010119-t1x9gknd 5880 12 of of IN cord-010119-t1x9gknd 5880 13 15mL 15ml NN cord-010119-t1x9gknd 5880 14 / / SYM cord-010119-t1x9gknd 5880 15 kg kg NNS cord-010119-t1x9gknd 5880 16 for for IN cord-010119-t1x9gknd 5880 17 all all DT cord-010119-t1x9gknd 5880 18 patients patient NNS cord-010119-t1x9gknd 5880 19 . . . cord-010119-t1x9gknd 5881 1 Complications complication NNS cord-010119-t1x9gknd 5881 2 noted note VBN cord-010119-t1x9gknd 5881 3 were be VBD cord-010119-t1x9gknd 5881 4 ; ; : cord-010119-t1x9gknd 5881 5 volume volume NN cord-010119-t1x9gknd 5881 6 overload overload NN cord-010119-t1x9gknd 5881 7 , , , cord-010119-t1x9gknd 5881 8 thrombosis thrombosis NN cord-010119-t1x9gknd 5881 9 , , , cord-010119-t1x9gknd 5881 10 fever fever NN cord-010119-t1x9gknd 5881 11 / / SYM cord-010119-t1x9gknd 5881 12 infection infection NN cord-010119-t1x9gknd 5881 13 , , , cord-010119-t1x9gknd 5881 14 hemolysis hemolysis NN cord-010119-t1x9gknd 5881 15 , , , cord-010119-t1x9gknd 5881 16 necrotizing necrotize VBG cord-010119-t1x9gknd 5881 17 enterocolitis enterocolitis NN cord-010119-t1x9gknd 5881 18 ( ( -LRB- cord-010119-t1x9gknd 5881 19 NEC NEC NNP cord-010119-t1x9gknd 5881 20 ) ) -RRB- cord-010119-t1x9gknd 5881 21 , , , cord-010119-t1x9gknd 5881 22 and and CC cord-010119-t1x9gknd 5881 23 death death NN cord-010119-t1x9gknd 5881 24 ( ( -LRB- cord-010119-t1x9gknd 5881 25 Table table NN cord-010119-t1x9gknd 5881 26 ) ) -RRB- cord-010119-t1x9gknd 5881 27 . . . cord-010119-t1x9gknd 5882 1 Conclusion conclusion NN cord-010119-t1x9gknd 5882 2 : : : cord-010119-t1x9gknd 5883 1 Evidence evidence NN cord-010119-t1x9gknd 5883 2 based base VBN cord-010119-t1x9gknd 5883 3 transfusion transfusion NN cord-010119-t1x9gknd 5883 4 guidelines guideline NNS cord-010119-t1x9gknd 5883 5 are be VBP cord-010119-t1x9gknd 5883 6 lacking lack VBG cord-010119-t1x9gknd 5883 7 in in IN cord-010119-t1x9gknd 5883 8 neonates neonate NNS cord-010119-t1x9gknd 5883 9 and and CC cord-010119-t1x9gknd 5883 10 infants infant NNS cord-010119-t1x9gknd 5883 11 . . . cord-010119-t1x9gknd 5884 1 A a DT cord-010119-t1x9gknd 5884 2 typical typical JJ cord-010119-t1x9gknd 5884 3 dose dose NN cord-010119-t1x9gknd 5884 4 of of IN cord-010119-t1x9gknd 5884 5 10 10 CD cord-010119-t1x9gknd 5884 6 - - SYM cord-010119-t1x9gknd 5884 7 15 15 CD cord-010119-t1x9gknd 5884 8 mL ml NN cord-010119-t1x9gknd 5884 9 / / SYM cord-010119-t1x9gknd 5884 10 kg kg NNS cord-010119-t1x9gknd 5884 11 in in IN cord-010119-t1x9gknd 5884 12 a a DT cord-010119-t1x9gknd 5884 13 2 2 CD cord-010119-t1x9gknd 5884 14 kg kg NN cord-010119-t1x9gknd 5884 15 patient patient NN cord-010119-t1x9gknd 5884 16 , , , cord-010119-t1x9gknd 5884 17 for for IN cord-010119-t1x9gknd 5884 18 instance instance NN cord-010119-t1x9gknd 5884 19 , , , cord-010119-t1x9gknd 5884 20 would would MD cord-010119-t1x9gknd 5884 21 translate translate VB cord-010119-t1x9gknd 5884 22 into into IN cord-010119-t1x9gknd 5884 23 3 3 CD cord-010119-t1x9gknd 5884 24 full full JJ cord-010119-t1x9gknd 5884 25 PRBC PRBC NNP cord-010119-t1x9gknd 5884 26 units unit NNS cord-010119-t1x9gknd 5884 27 ( ( -LRB- cord-010119-t1x9gknd 5884 28 about about RB cord-010119-t1x9gknd 5884 29 1000 1000 CD cord-010119-t1x9gknd 5884 30 mL ml NN cord-010119-t1x9gknd 5884 31 ) ) -RRB- cord-010119-t1x9gknd 5884 32 in in IN cord-010119-t1x9gknd 5884 33 an an DT cord-010119-t1x9gknd 5884 34 average average JJ cord-010119-t1x9gknd 5884 35 size size NN cord-010119-t1x9gknd 5884 36 adult adult NN cord-010119-t1x9gknd 5884 37 . . . cord-010119-t1x9gknd 5885 1 The the DT cord-010119-t1x9gknd 5885 2 current current JJ cord-010119-t1x9gknd 5885 3 standard standard JJ cord-010119-t1x9gknd 5885 4 dose dose NN cord-010119-t1x9gknd 5885 5 of of IN cord-010119-t1x9gknd 5885 6 10 10 CD cord-010119-t1x9gknd 5885 7 - - SYM cord-010119-t1x9gknd 5885 8 15 15 CD cord-010119-t1x9gknd 5885 9 mL ml NN cord-010119-t1x9gknd 5885 10 / / SYM cord-010119-t1x9gknd 5885 11 kg kg NN cord-010119-t1x9gknd 5885 12 yields yield NNS cord-010119-t1x9gknd 5885 13 very very RB cord-010119-t1x9gknd 5885 14 high high JJ cord-010119-t1x9gknd 5885 15 increases increase NNS cord-010119-t1x9gknd 5885 16 in in IN cord-010119-t1x9gknd 5885 17 Hgb Hgb NNP cord-010119-t1x9gknd 5885 18 and and CC cord-010119-t1x9gknd 5885 19 may may MD cord-010119-t1x9gknd 5885 20 put put VB cord-010119-t1x9gknd 5885 21 these these DT cord-010119-t1x9gknd 5885 22 patients patient NNS cord-010119-t1x9gknd 5885 23 at at IN cord-010119-t1x9gknd 5885 24 risk risk NN cord-010119-t1x9gknd 5885 25 of of IN cord-010119-t1x9gknd 5885 26 adverse adverse JJ cord-010119-t1x9gknd 5885 27 outcomes outcome NNS cord-010119-t1x9gknd 5885 28 , , , cord-010119-t1x9gknd 5885 29 especially especially RB cord-010119-t1x9gknd 5885 30 thrombosis thrombosis NN cord-010119-t1x9gknd 5885 31 due due IN cord-010119-t1x9gknd 5885 32 to to IN cord-010119-t1x9gknd 5885 33 increased increase VBN cord-010119-t1x9gknd 5885 34 blood blood NN cord-010119-t1x9gknd 5885 35 viscosity viscosity NN cord-010119-t1x9gknd 5885 36 . . . cord-010119-t1x9gknd 5886 1 Additionally additionally RB cord-010119-t1x9gknd 5886 2 , , , cord-010119-t1x9gknd 5886 3 many many JJ cord-010119-t1x9gknd 5886 4 of of IN cord-010119-t1x9gknd 5886 5 these these DT cord-010119-t1x9gknd 5886 6 patients patient NNS cord-010119-t1x9gknd 5886 7 received receive VBD cord-010119-t1x9gknd 5886 8 volume volume NN cord-010119-t1x9gknd 5886 9 reduced reduce VBN cord-010119-t1x9gknd 5886 10 products product NNS cord-010119-t1x9gknd 5886 11 which which WDT cord-010119-t1x9gknd 5886 12 delivers deliver VBZ cord-010119-t1x9gknd 5886 13 a a DT cord-010119-t1x9gknd 5886 14 higher high JJR cord-010119-t1x9gknd 5886 15 Hgb Hgb NNP cord-010119-t1x9gknd 5886 16 concentration concentration NN cord-010119-t1x9gknd 5886 17 per per IN cord-010119-t1x9gknd 5886 18 transfusion transfusion NN cord-010119-t1x9gknd 5886 19 . . . cord-010119-t1x9gknd 5887 1 Dosing dosing NN cord-010119-t1x9gknd 5887 2 should should MD cord-010119-t1x9gknd 5887 3 be be VB cord-010119-t1x9gknd 5887 4 based base VBN cord-010119-t1x9gknd 5887 5 on on IN cord-010119-t1x9gknd 5887 6 goal goal NN cord-010119-t1x9gknd 5887 7 Hgb Hgb NNP cord-010119-t1x9gknd 5887 8 and and CC cord-010119-t1x9gknd 5887 9 patient patient JJ cord-010119-t1x9gknd 5887 10 condition condition NN cord-010119-t1x9gknd 5887 11 rather rather RB cord-010119-t1x9gknd 5887 12 than than IN cord-010119-t1x9gknd 5887 13 weight weight NN cord-010119-t1x9gknd 5887 14 based base VBN cord-010119-t1x9gknd 5887 15 , , , cord-010119-t1x9gknd 5887 16 though though IN cord-010119-t1x9gknd 5887 17 the the DT cord-010119-t1x9gknd 5887 18 hematocrit hematocrit NN cord-010119-t1x9gknd 5887 19 level level NN cord-010119-t1x9gknd 5887 20 at at IN cord-010119-t1x9gknd 5887 21 which which WDT cord-010119-t1x9gknd 5887 22 the the DT cord-010119-t1x9gknd 5887 23 benefits benefit NNS cord-010119-t1x9gknd 5887 24 outweigh outweigh VBP cord-010119-t1x9gknd 5887 25 the the DT cord-010119-t1x9gknd 5887 26 risks risk NNS cord-010119-t1x9gknd 5887 27 remains remain VBZ cord-010119-t1x9gknd 5887 28 unclear unclear JJ cord-010119-t1x9gknd 5887 29 . . . cord-010119-t1x9gknd 5888 1 pneumoniae pneumoniae NN cord-010119-t1x9gknd 5888 2 has have VBZ cord-010119-t1x9gknd 5888 3 rarely rarely RB cord-010119-t1x9gknd 5888 4 been be VBN cord-010119-t1x9gknd 5888 5 associated associate VBN cord-010119-t1x9gknd 5888 6 with with IN cord-010119-t1x9gknd 5888 7 warm warm JJ cord-010119-t1x9gknd 5888 8 autoimmune autoimmune JJ cord-010119-t1x9gknd 5888 9 hemolytic hemolytic JJ cord-010119-t1x9gknd 5888 10 anemia anemia NN cord-010119-t1x9gknd 5888 11 , , , cord-010119-t1x9gknd 5888 12 with with IN cord-010119-t1x9gknd 5888 13 only only RB cord-010119-t1x9gknd 5888 14 3 3 CD cord-010119-t1x9gknd 5888 15 case case NN cord-010119-t1x9gknd 5888 16 reports report NNS cord-010119-t1x9gknd 5888 17 suggesting suggest VBG cord-010119-t1x9gknd 5888 18 this this DT cord-010119-t1x9gknd 5888 19 association association NN cord-010119-t1x9gknd 5888 20 . . . cord-010119-t1x9gknd 5889 1 However however RB cord-010119-t1x9gknd 5889 2 , , , cord-010119-t1x9gknd 5889 3 each each DT cord-010119-t1x9gknd 5889 4 of of IN cord-010119-t1x9gknd 5889 5 these these DT cord-010119-t1x9gknd 5889 6 cases case NNS cord-010119-t1x9gknd 5889 7 is be VBZ cord-010119-t1x9gknd 5889 8 confounded confound VBN cord-010119-t1x9gknd 5889 9 by by IN cord-010119-t1x9gknd 5889 10 other other JJ cord-010119-t1x9gknd 5889 11 findings finding NNS cord-010119-t1x9gknd 5889 12 in in IN cord-010119-t1x9gknd 5889 13 addition addition NN cord-010119-t1x9gknd 5889 14 to to IN cord-010119-t1x9gknd 5889 15 a a DT cord-010119-t1x9gknd 5889 16 Mycoplasma Mycoplasma NNP cord-010119-t1x9gknd 5889 17 infection infection NN cord-010119-t1x9gknd 5889 18 . . . cord-010119-t1x9gknd 5890 1 We -PRON- PRP cord-010119-t1x9gknd 5890 2 describe describe VBP cord-010119-t1x9gknd 5890 3 a a DT cord-010119-t1x9gknd 5890 4 unique unique JJ cord-010119-t1x9gknd 5890 5 case case NN cord-010119-t1x9gknd 5890 6 in in IN cord-010119-t1x9gknd 5890 7 which which WDT cord-010119-t1x9gknd 5890 8 a a DT cord-010119-t1x9gknd 5890 9 pediatric pediatric JJ cord-010119-t1x9gknd 5890 10 patient patient NN cord-010119-t1x9gknd 5890 11 has have VBZ cord-010119-t1x9gknd 5890 12 clear clear JJ cord-010119-t1x9gknd 5890 13 evidence evidence NN cord-010119-t1x9gknd 5890 14 of of IN cord-010119-t1x9gknd 5890 15 severe severe JJ cord-010119-t1x9gknd 5890 16 hemolysis hemolysis NN cord-010119-t1x9gknd 5890 17 , , , cord-010119-t1x9gknd 5890 18 a a DT cord-010119-t1x9gknd 5890 19 very very RB cord-010119-t1x9gknd 5890 20 strongly strongly RB cord-010119-t1x9gknd 5890 21 reactive reactive JJ cord-010119-t1x9gknd 5890 22 warm warm JJ cord-010119-t1x9gknd 5890 23 autoantibody autoantibody NN cord-010119-t1x9gknd 5890 24 , , , cord-010119-t1x9gknd 5890 25 and and CC cord-010119-t1x9gknd 5890 26 clinical clinical JJ cord-010119-t1x9gknd 5890 27 and and CC cord-010119-t1x9gknd 5890 28 laboratory laboratory JJ cord-010119-t1x9gknd 5890 29 evidence evidence NN cord-010119-t1x9gknd 5890 30 of of IN cord-010119-t1x9gknd 5890 31 a a DT cord-010119-t1x9gknd 5890 32 Mycoplasma Mycoplasma NNP cord-010119-t1x9gknd 5890 33 infection infection NN cord-010119-t1x9gknd 5890 34 without without IN cord-010119-t1x9gknd 5890 35 a a DT cord-010119-t1x9gknd 5890 36 detectable detectable JJ cord-010119-t1x9gknd 5890 37 cold cold JJ cord-010119-t1x9gknd 5890 38 agglutinin agglutinin NNS cord-010119-t1x9gknd 5890 39 . . . cord-010119-t1x9gknd 5891 1 Study Study NNP cord-010119-t1x9gknd 5891 2 Design Design NNP cord-010119-t1x9gknd 5891 3 / / SYM cord-010119-t1x9gknd 5891 4 Methods method NNS cord-010119-t1x9gknd 5891 5 : : : cord-010119-t1x9gknd 5891 6 The the DT cord-010119-t1x9gknd 5891 7 patient patient NN cord-010119-t1x9gknd 5891 8 is be VBZ cord-010119-t1x9gknd 5891 9 a a DT cord-010119-t1x9gknd 5891 10 7month 7month JJ cord-010119-t1x9gknd 5891 11 - - HYPH cord-010119-t1x9gknd 5891 12 old old JJ cord-010119-t1x9gknd 5891 13 , , , cord-010119-t1x9gknd 5891 14 previously previously RB cord-010119-t1x9gknd 5891 15 healthy healthy JJ cord-010119-t1x9gknd 5891 16 female female JJ cord-010119-t1x9gknd 5891 17 infant infant NN cord-010119-t1x9gknd 5891 18 who who WP cord-010119-t1x9gknd 5891 19 presented present VBD cord-010119-t1x9gknd 5891 20 to to IN cord-010119-t1x9gknd 5891 21 the the DT cord-010119-t1x9gknd 5891 22 hospital hospital NN cord-010119-t1x9gknd 5891 23 with with IN cord-010119-t1x9gknd 5891 24 a a DT cord-010119-t1x9gknd 5891 25 1-week 1-week CD cord-010119-t1x9gknd 5891 26 history history NN cord-010119-t1x9gknd 5891 27 of of IN cord-010119-t1x9gknd 5891 28 fever fever NN cord-010119-t1x9gknd 5891 29 , , , cord-010119-t1x9gknd 5891 30 fatigue fatigue NN cord-010119-t1x9gknd 5891 31 , , , cord-010119-t1x9gknd 5891 32 decreased decrease VBD cord-010119-t1x9gknd 5891 33 appetite appetite NN cord-010119-t1x9gknd 5891 34 , , , cord-010119-t1x9gknd 5891 35 and and CC cord-010119-t1x9gknd 5891 36 pallor pallor NN cord-010119-t1x9gknd 5891 37 . . . cord-010119-t1x9gknd 5892 1 She -PRON- PRP cord-010119-t1x9gknd 5892 2 was be VBD cord-010119-t1x9gknd 5892 3 only only RB cord-010119-t1x9gknd 5892 4 treated treat VBN cord-010119-t1x9gknd 5892 5 with with IN cord-010119-t1x9gknd 5892 6 acetaminophen acetaminophen NN cord-010119-t1x9gknd 5892 7 . . . cord-010119-t1x9gknd 5893 1 She -PRON- PRP cord-010119-t1x9gknd 5893 2 also also RB cord-010119-t1x9gknd 5893 3 developed develop VBD cord-010119-t1x9gknd 5893 4 clear clear JJ cord-010119-t1x9gknd 5893 5 rhinorrhea rhinorrhea NN cord-010119-t1x9gknd 5893 6 the the DT cord-010119-t1x9gknd 5893 7 day day NN cord-010119-t1x9gknd 5893 8 before before IN cord-010119-t1x9gknd 5893 9 hospital hospital NN cord-010119-t1x9gknd 5893 10 admission admission NN cord-010119-t1x9gknd 5893 11 . . . cord-010119-t1x9gknd 5894 1 At at IN cord-010119-t1x9gknd 5894 2 the the DT cord-010119-t1x9gknd 5894 3 time time NN cord-010119-t1x9gknd 5894 4 of of IN cord-010119-t1x9gknd 5894 5 her -PRON- PRP$ cord-010119-t1x9gknd 5894 6 admission admission NN cord-010119-t1x9gknd 5894 7 , , , cord-010119-t1x9gknd 5894 8 laboratory laboratory NN cord-010119-t1x9gknd 5894 9 testing testing NN cord-010119-t1x9gknd 5894 10 ( ( -LRB- cord-010119-t1x9gknd 5894 11 outside outside JJ cord-010119-t1x9gknd 5894 12 hospital hospital NN cord-010119-t1x9gknd 5894 13 ) ) -RRB- cord-010119-t1x9gknd 5894 14 revealed reveal VBD cord-010119-t1x9gknd 5894 15 a a DT cord-010119-t1x9gknd 5894 16 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5894 17 and and CC cord-010119-t1x9gknd 5894 18 hematocrit hematocrit NN cord-010119-t1x9gknd 5894 19 of of IN cord-010119-t1x9gknd 5894 20 2.7 2.7 CD cord-010119-t1x9gknd 5894 21 g g NN cord-010119-t1x9gknd 5894 22 / / SYM cord-010119-t1x9gknd 5894 23 dL dl NN cord-010119-t1x9gknd 5894 24 and and CC cord-010119-t1x9gknd 5894 25 9.1 9.1 CD cord-010119-t1x9gknd 5894 26 % % NN cord-010119-t1x9gknd 5894 27 , , , cord-010119-t1x9gknd 5894 28 respectively respectively RB cord-010119-t1x9gknd 5894 29 , , , cord-010119-t1x9gknd 5894 30 platelets platelet NNS cord-010119-t1x9gknd 5894 31 of of IN cord-010119-t1x9gknd 5894 32 635,000 635,000 CD cord-010119-t1x9gknd 5894 33 , , , cord-010119-t1x9gknd 5894 34 and and CC cord-010119-t1x9gknd 5894 35 a a DT cord-010119-t1x9gknd 5894 36 reticulocyte reticulocyte JJ cord-010119-t1x9gknd 5894 37 count count NN cord-010119-t1x9gknd 5894 38 of of IN cord-010119-t1x9gknd 5894 39 10.3 10.3 CD cord-010119-t1x9gknd 5894 40 % % NN cord-010119-t1x9gknd 5894 41 . . . cord-010119-t1x9gknd 5895 1 All all DT cord-010119-t1x9gknd 5895 2 other other JJ cord-010119-t1x9gknd 5895 3 elements element NNS cord-010119-t1x9gknd 5895 4 of of IN cord-010119-t1x9gknd 5895 5 the the DT cord-010119-t1x9gknd 5895 6 complete complete JJ cord-010119-t1x9gknd 5895 7 blood blood NN cord-010119-t1x9gknd 5895 8 count count NN cord-010119-t1x9gknd 5895 9 were be VBD cord-010119-t1x9gknd 5895 10 within within IN cord-010119-t1x9gknd 5895 11 the the DT cord-010119-t1x9gknd 5895 12 normal normal JJ cord-010119-t1x9gknd 5895 13 reference reference NN cord-010119-t1x9gknd 5895 14 range range NN cord-010119-t1x9gknd 5895 15 for for IN cord-010119-t1x9gknd 5895 16 age age NN cord-010119-t1x9gknd 5895 17 . . . cord-010119-t1x9gknd 5896 1 A a DT cord-010119-t1x9gknd 5896 2 complete complete JJ cord-010119-t1x9gknd 5896 3 metabolic metabolic JJ cord-010119-t1x9gknd 5896 4 panel panel NN cord-010119-t1x9gknd 5896 5 revealed reveal VBD cord-010119-t1x9gknd 5896 6 no no DT cord-010119-t1x9gknd 5896 7 abnormalities abnormality NNS cord-010119-t1x9gknd 5896 8 except except IN cord-010119-t1x9gknd 5896 9 for for IN cord-010119-t1x9gknd 5896 10 a a DT cord-010119-t1x9gknd 5896 11 total total JJ cord-010119-t1x9gknd 5896 12 bilirubin bilirubin NN cord-010119-t1x9gknd 5896 13 of of IN cord-010119-t1x9gknd 5896 14 4.9 4.9 CD cord-010119-t1x9gknd 5896 15 mg mg NNP cord-010119-t1x9gknd 5896 16 / / SYM cord-010119-t1x9gknd 5896 17 dL dl NN cord-010119-t1x9gknd 5896 18 with with IN cord-010119-t1x9gknd 5896 19 a a DT cord-010119-t1x9gknd 5896 20 direct direct JJ cord-010119-t1x9gknd 5896 21 fraction fraction NN cord-010119-t1x9gknd 5896 22 of of IN cord-010119-t1x9gknd 5896 23 0.43 0.43 CD cord-010119-t1x9gknd 5896 24 mg/ mg/ NN cord-010119-t1x9gknd 5897 1 dL. dL. NNP cord-010119-t1x9gknd 5897 2 A a DT cord-010119-t1x9gknd 5897 3 FilmArray FilmArray NNP cord-010119-t1x9gknd 5897 4 Respiratory Respiratory NNP cord-010119-t1x9gknd 5897 5 Panel panel NN cord-010119-t1x9gknd 5898 1 ( ( -LRB- cord-010119-t1x9gknd 5898 2 BioFire BioFire NNP cord-010119-t1x9gknd 5898 3 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 5898 4 ; ; : cord-010119-t1x9gknd 5898 5 Salt Salt NNP cord-010119-t1x9gknd 5898 6 Lake Lake NNP cord-010119-t1x9gknd 5898 7 City City NNP cord-010119-t1x9gknd 5898 8 , , , cord-010119-t1x9gknd 5898 9 UT UT NNP cord-010119-t1x9gknd 5898 10 ) ) -RRB- cord-010119-t1x9gknd 5898 11 detected detect VBD cord-010119-t1x9gknd 5898 12 Mycoplasma Mycoplasma NNP cord-010119-t1x9gknd 5898 13 pneumoniae pneumoniae NNS cord-010119-t1x9gknd 5898 14 , , , cord-010119-t1x9gknd 5898 15 while while IN cord-010119-t1x9gknd 5898 16 all all DT cord-010119-t1x9gknd 5898 17 other other JJ cord-010119-t1x9gknd 5898 18 pathogens pathogen NNS cord-010119-t1x9gknd 5898 19 ( ( -LRB- cord-010119-t1x9gknd 5898 20 19 19 CD cord-010119-t1x9gknd 5898 21 total total NN cord-010119-t1x9gknd 5898 22 ) ) -RRB- cord-010119-t1x9gknd 5898 23 were be VBD cord-010119-t1x9gknd 5898 24 non non JJ cord-010119-t1x9gknd 5898 25 - - JJ cord-010119-t1x9gknd 5898 26 detectable detectable JJ cord-010119-t1x9gknd 5898 27 . . . cord-010119-t1x9gknd 5899 1 The the DT cord-010119-t1x9gknd 5899 2 patient patient NN cord-010119-t1x9gknd 5899 3 was be VBD cord-010119-t1x9gknd 5899 4 started start VBN cord-010119-t1x9gknd 5899 5 on on IN cord-010119-t1x9gknd 5899 6 a a DT cord-010119-t1x9gknd 5899 7 5-day 5-day JJ cord-010119-t1x9gknd 5899 8 course course NN cord-010119-t1x9gknd 5899 9 of of IN cord-010119-t1x9gknd 5899 10 azithromycin azithromycin NN cord-010119-t1x9gknd 5899 11 ( ( -LRB- cord-010119-t1x9gknd 5899 12 Zithromax Zithromax NNP cord-010119-t1x9gknd 5899 13 ) ) -RRB- cord-010119-t1x9gknd 5899 14 . . . cord-010119-t1x9gknd 5900 1 Results result NNS cord-010119-t1x9gknd 5900 2 / / SYM cord-010119-t1x9gknd 5900 3 Findings finding NNS cord-010119-t1x9gknd 5900 4 : : : cord-010119-t1x9gknd 5901 1 Prior prior RB cord-010119-t1x9gknd 5901 2 to to IN cord-010119-t1x9gknd 5901 3 RBC RBC NNP cord-010119-t1x9gknd 5901 4 transfusion transfusion NN cord-010119-t1x9gknd 5901 5 , , , cord-010119-t1x9gknd 5901 6 blood blood NN cord-010119-t1x9gknd 5901 7 bank bank NN cord-010119-t1x9gknd 5901 8 evaluation evaluation NN cord-010119-t1x9gknd 5901 9 revealed reveal VBD cord-010119-t1x9gknd 5901 10 that that IN cord-010119-t1x9gknd 5901 11 the the DT cord-010119-t1x9gknd 5901 12 patient patient NN cord-010119-t1x9gknd 5901 13 was be VBD cord-010119-t1x9gknd 5901 14 O o NN cord-010119-t1x9gknd 5901 15 - - HYPH cord-010119-t1x9gknd 5901 16 positive positive JJ cord-010119-t1x9gknd 5901 17 and and CC cord-010119-t1x9gknd 5901 18 had have VBD cord-010119-t1x9gknd 5901 19 a a DT cord-010119-t1x9gknd 5901 20 stronglyreactive stronglyreactive JJ cord-010119-t1x9gknd 5901 21 antibody antibody NN cord-010119-t1x9gknd 5901 22 screen screen NN cord-010119-t1x9gknd 5901 23 . . . cord-010119-t1x9gknd 5902 1 Further further JJ cord-010119-t1x9gknd 5902 2 testing testing NN cord-010119-t1x9gknd 5902 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 5902 4 an an DT cord-010119-t1x9gknd 5902 5 antibody antibody NN cord-010119-t1x9gknd 5902 6 reactive reactive JJ cord-010119-t1x9gknd 5902 7 with with IN cord-010119-t1x9gknd 5902 8 all all DT cord-010119-t1x9gknd 5902 9 reagent reagent JJ cord-010119-t1x9gknd 5902 10 red red JJ cord-010119-t1x9gknd 5902 11 blood blood NN cord-010119-t1x9gknd 5902 12 cells cell NNS cord-010119-t1x9gknd 5902 13 . . . cord-010119-t1x9gknd 5903 1 The the DT cord-010119-t1x9gknd 5903 2 DAT DAT NNP cord-010119-t1x9gknd 5903 3 was be VBD cord-010119-t1x9gknd 5903 4 strongly strongly RB cord-010119-t1x9gknd 5903 5 reactive reactive JJ cord-010119-t1x9gknd 5903 6 for for IN cord-010119-t1x9gknd 5903 7 IgG IgG NNP cord-010119-t1x9gknd 5903 8 but but CC cord-010119-t1x9gknd 5903 9 very very RB cord-010119-t1x9gknd 5903 10 weakly weakly RB cord-010119-t1x9gknd 5903 11 reactive reactive JJ cord-010119-t1x9gknd 5903 12 for for IN cord-010119-t1x9gknd 5903 13 C3 C3 NNP cord-010119-t1x9gknd 5903 14 . . . cord-010119-t1x9gknd 5904 1 An an DT cord-010119-t1x9gknd 5904 2 eluate eluate NN cord-010119-t1x9gknd 5904 3 was be VBD cord-010119-t1x9gknd 5904 4 reactive reactive JJ cord-010119-t1x9gknd 5904 5 with with IN cord-010119-t1x9gknd 5904 6 all all DT cord-010119-t1x9gknd 5904 7 reagent reagent JJ cord-010119-t1x9gknd 5904 8 red red JJ cord-010119-t1x9gknd 5904 9 cells cell NNS cord-010119-t1x9gknd 5904 10 tested test VBN cord-010119-t1x9gknd 5904 11 . . . cord-010119-t1x9gknd 5905 1 Finally finally RB cord-010119-t1x9gknd 5905 2 , , , cord-010119-t1x9gknd 5905 3 a a DT cord-010119-t1x9gknd 5905 4 cold cold JJ cord-010119-t1x9gknd 5905 5 agglutinin agglutinin NNS cord-010119-t1x9gknd 5905 6 study study NN cord-010119-t1x9gknd 5905 7 was be VBD cord-010119-t1x9gknd 5905 8 negative negative JJ cord-010119-t1x9gknd 5905 9 with with IN cord-010119-t1x9gknd 5905 10 undiluted undiluted JJ cord-010119-t1x9gknd 5905 11 serum serum NN cord-010119-t1x9gknd 5905 12 . . . cord-010119-t1x9gknd 5906 1 In in IN cord-010119-t1x9gknd 5906 2 addition addition NN cord-010119-t1x9gknd 5906 3 to to IN cord-010119-t1x9gknd 5906 4 starting start VBG cord-010119-t1x9gknd 5906 5 azithromycin azithromycin NNP cord-010119-t1x9gknd 5906 6 , , , cord-010119-t1x9gknd 5906 7 the the DT cord-010119-t1x9gknd 5906 8 patient patient NN cord-010119-t1x9gknd 5906 9 was be VBD cord-010119-t1x9gknd 5906 10 given give VBN cord-010119-t1x9gknd 5906 11 IV IV NNP cord-010119-t1x9gknd 5906 12 methylprednisolone methylprednisolone NN cord-010119-t1x9gknd 5906 13 . . . cord-010119-t1x9gknd 5907 1 During during IN cord-010119-t1x9gknd 5907 2 her -PRON- PRP$ cord-010119-t1x9gknd 5907 3 8-day 8-day JJ cord-010119-t1x9gknd 5907 4 hospital hospital NN cord-010119-t1x9gknd 5907 5 course course NN cord-010119-t1x9gknd 5907 6 , , , cord-010119-t1x9gknd 5907 7 the the DT cord-010119-t1x9gknd 5907 8 patient patient NN cord-010119-t1x9gknd 5907 9 received receive VBD cord-010119-t1x9gknd 5907 10 2 2 CD cord-010119-t1x9gknd 5907 11 RBC RBC NNP cord-010119-t1x9gknd 5907 12 transfusions transfusion NNS cord-010119-t1x9gknd 5907 13 on on IN cord-010119-t1x9gknd 5907 14 the the DT cord-010119-t1x9gknd 5907 15 day day NN cord-010119-t1x9gknd 5907 16 of of IN cord-010119-t1x9gknd 5907 17 admission admission NN cord-010119-t1x9gknd 5907 18 and and CC cord-010119-t1x9gknd 5907 19 several several JJ cord-010119-t1x9gknd 5907 20 RBC RBC NNP cord-010119-t1x9gknd 5907 21 transfusions transfusion NNS cord-010119-t1x9gknd 5907 22 thereafter thereafter RB cord-010119-t1x9gknd 5907 23 ( ( -LRB- cord-010119-t1x9gknd 5907 24 see see VB cord-010119-t1x9gknd 5907 25 Table table NN cord-010119-t1x9gknd 5907 26 1 1 CD cord-010119-t1x9gknd 5907 27 ) ) -RRB- cord-010119-t1x9gknd 5907 28 . . . cord-010119-t1x9gknd 5908 1 Despite despite IN cord-010119-t1x9gknd 5908 2 transfusion transfusion NN cord-010119-t1x9gknd 5908 3 , , , cord-010119-t1x9gknd 5908 4 her -PRON- PRP$ cord-010119-t1x9gknd 5908 5 hemolytic hemolytic JJ cord-010119-t1x9gknd 5908 6 process process NN cord-010119-t1x9gknd 5908 7 persisted persist VBD cord-010119-t1x9gknd 5908 8 , , , cord-010119-t1x9gknd 5908 9 so so RB cord-010119-t1x9gknd 5908 10 she -PRON- PRP cord-010119-t1x9gknd 5908 11 was be VBD cord-010119-t1x9gknd 5908 12 infused infuse VBN cord-010119-t1x9gknd 5908 13 with with IN cord-010119-t1x9gknd 5908 14 a a DT cord-010119-t1x9gknd 5908 15 dose dose NN cord-010119-t1x9gknd 5908 16 of of IN cord-010119-t1x9gknd 5908 17 IV IV NNP cord-010119-t1x9gknd 5908 18 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 5908 19 on on IN cord-010119-t1x9gknd 5908 20 hospital hospital NN cord-010119-t1x9gknd 5908 21 day day NN cord-010119-t1x9gknd 5908 22 6 6 CD cord-010119-t1x9gknd 5908 23 . . . cord-010119-t1x9gknd 5909 1 Her -PRON- PRP$ cord-010119-t1x9gknd 5909 2 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5909 3 rose rise VBD cord-010119-t1x9gknd 5909 4 to to IN cord-010119-t1x9gknd 5909 5 8.4 8.4 CD cord-010119-t1x9gknd 5909 6 g g NN cord-010119-t1x9gknd 5909 7 / / SYM cord-010119-t1x9gknd 5909 8 dL dl NN cord-010119-t1x9gknd 5909 9 on on IN cord-010119-t1x9gknd 5909 10 hospital hospital NN cord-010119-t1x9gknd 5909 11 day day NN cord-010119-t1x9gknd 5909 12 7 7 CD cord-010119-t1x9gknd 5909 13 and and CC cord-010119-t1x9gknd 5909 14 increased increase VBD cord-010119-t1x9gknd 5909 15 to to IN cord-010119-t1x9gknd 5909 16 9.5 9.5 CD cord-010119-t1x9gknd 5909 17 g g NN cord-010119-t1x9gknd 5909 18 / / SYM cord-010119-t1x9gknd 5909 19 dL dl NN cord-010119-t1x9gknd 5909 20 on on IN cord-010119-t1x9gknd 5909 21 hospital hospital NN cord-010119-t1x9gknd 5909 22 day day NN cord-010119-t1x9gknd 5909 23 8 8 CD cord-010119-t1x9gknd 5909 24 . . . cord-010119-t1x9gknd 5910 1 At at IN cord-010119-t1x9gknd 5910 2 that that DT cord-010119-t1x9gknd 5910 3 time time NN cord-010119-t1x9gknd 5910 4 , , , cord-010119-t1x9gknd 5910 5 the the DT cord-010119-t1x9gknd 5910 6 patient patient NN cord-010119-t1x9gknd 5910 7 was be VBD cord-010119-t1x9gknd 5910 8 discharged discharge VBN cord-010119-t1x9gknd 5910 9 from from IN cord-010119-t1x9gknd 5910 10 the the DT cord-010119-t1x9gknd 5910 11 hospital hospital NN cord-010119-t1x9gknd 5910 12 with with IN cord-010119-t1x9gknd 5910 13 instructions instruction NNS cord-010119-t1x9gknd 5910 14 to to TO cord-010119-t1x9gknd 5910 15 wean wean VB cord-010119-t1x9gknd 5910 16 her -PRON- PRP$ cord-010119-t1x9gknd 5910 17 oral oral JJ cord-010119-t1x9gknd 5910 18 steroid steroid NN cord-010119-t1x9gknd 5910 19 dose dose NN cord-010119-t1x9gknd 5910 20 over over IN cord-010119-t1x9gknd 5910 21 the the DT cord-010119-t1x9gknd 5910 22 next next JJ cord-010119-t1x9gknd 5910 23 2 2 CD cord-010119-t1x9gknd 5910 24 weeks week NNS cord-010119-t1x9gknd 5910 25 . . . cord-010119-t1x9gknd 5911 1 She -PRON- PRP cord-010119-t1x9gknd 5911 2 was be VBD cord-010119-t1x9gknd 5911 3 followed follow VBN cord-010119-t1x9gknd 5911 4 closely closely RB cord-010119-t1x9gknd 5911 5 by by IN cord-010119-t1x9gknd 5911 6 the the DT cord-010119-t1x9gknd 5911 7 hematology hematology NN cord-010119-t1x9gknd 5911 8 clinic clinic NN cord-010119-t1x9gknd 5911 9 and and CC cord-010119-t1x9gknd 5911 10 was be VBD cord-010119-t1x9gknd 5911 11 found find VBN cord-010119-t1x9gknd 5911 12 to to TO cord-010119-t1x9gknd 5911 13 have have VB cord-010119-t1x9gknd 5911 14 a a DT cord-010119-t1x9gknd 5911 15 stable stable JJ cord-010119-t1x9gknd 5911 16 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5911 17 ( ( -LRB- cord-010119-t1x9gknd 5911 18 up up IN cord-010119-t1x9gknd 5911 19 to to IN cord-010119-t1x9gknd 5911 20 11.2 11.2 CD cord-010119-t1x9gknd 5911 21 g g NN cord-010119-t1x9gknd 5911 22 / / SYM cord-010119-t1x9gknd 5911 23 dL dl NN cord-010119-t1x9gknd 5911 24 on on IN cord-010119-t1x9gknd 5911 25 day day NN cord-010119-t1x9gknd 5911 26 57 57 CD cord-010119-t1x9gknd 5911 27 after after IN cord-010119-t1x9gknd 5911 28 her -PRON- PRP$ cord-010119-t1x9gknd 5911 29 hospital hospital NN cord-010119-t1x9gknd 5911 30 admission admission NN cord-010119-t1x9gknd 5911 31 ) ) -RRB- cord-010119-t1x9gknd 5911 32 with with IN cord-010119-t1x9gknd 5911 33 no no DT cord-010119-t1x9gknd 5911 34 recurrence recurrence NN cord-010119-t1x9gknd 5911 35 of of IN cord-010119-t1x9gknd 5911 36 her -PRON- PRP$ cord-010119-t1x9gknd 5911 37 hemolytic hemolytic JJ cord-010119-t1x9gknd 5911 38 process process NN cord-010119-t1x9gknd 5911 39 . . . cord-010119-t1x9gknd 5912 1 Conclusion conclusion NN cord-010119-t1x9gknd 5912 2 : : : cord-010119-t1x9gknd 5913 1 M. M. NNP cord-010119-t1x9gknd 5913 2 pneumoniae pneumoniae NN cord-010119-t1x9gknd 5913 3 infection infection NN cord-010119-t1x9gknd 5913 4 is be VBZ cord-010119-t1x9gknd 5913 5 a a DT cord-010119-t1x9gknd 5913 6 typical typical JJ cord-010119-t1x9gknd 5913 7 cause cause NN cord-010119-t1x9gknd 5913 8 of of IN cord-010119-t1x9gknd 5913 9 CAD CAD NNP cord-010119-t1x9gknd 5913 10 and and CC cord-010119-t1x9gknd 5913 11 has have VBZ cord-010119-t1x9gknd 5913 12 only only RB cord-010119-t1x9gknd 5913 13 rarely rarely RB cord-010119-t1x9gknd 5913 14 been be VBN cord-010119-t1x9gknd 5913 15 associated associate VBN cord-010119-t1x9gknd 5913 16 with with IN cord-010119-t1x9gknd 5913 17 warm warm JJ cord-010119-t1x9gknd 5913 18 autoimmune autoimmune JJ cord-010119-t1x9gknd 5913 19 hemolytic hemolytic JJ cord-010119-t1x9gknd 5913 20 anemia anemia NN cord-010119-t1x9gknd 5913 21 . . . cord-010119-t1x9gknd 5914 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5914 2 case case NN cord-010119-t1x9gknd 5914 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 5914 4 clear clear JJ cord-010119-t1x9gknd 5914 5 evidence evidence NN cord-010119-t1x9gknd 5914 6 of of IN cord-010119-t1x9gknd 5914 7 severe severe JJ cord-010119-t1x9gknd 5914 8 warm warm JJ cord-010119-t1x9gknd 5914 9 autoimmune autoimmune JJ cord-010119-t1x9gknd 5914 10 hemolysis hemolysis NN cord-010119-t1x9gknd 5914 11 in in IN cord-010119-t1x9gknd 5914 12 a a DT cord-010119-t1x9gknd 5914 13 previously previously RB cord-010119-t1x9gknd 5914 14 healthy healthy JJ cord-010119-t1x9gknd 5914 15 infant infant NN cord-010119-t1x9gknd 5914 16 . . . cord-010119-t1x9gknd 5915 1 With with IN cord-010119-t1x9gknd 5915 2 the the DT cord-010119-t1x9gknd 5915 3 increasing increase VBG cord-010119-t1x9gknd 5915 4 use use NN cord-010119-t1x9gknd 5915 5 of of IN cord-010119-t1x9gknd 5915 6 multiplex multiplex JJ cord-010119-t1x9gknd 5915 7 respiratory respiratory JJ cord-010119-t1x9gknd 5915 8 viral viral JJ cord-010119-t1x9gknd 5915 9 and and CC cord-010119-t1x9gknd 5915 10 bacterial bacterial JJ cord-010119-t1x9gknd 5915 11 pathogen pathogen NN cord-010119-t1x9gknd 5915 12 detection detection NN cord-010119-t1x9gknd 5915 13 systems system NNS cord-010119-t1x9gknd 5915 14 , , , cord-010119-t1x9gknd 5915 15 the the DT cord-010119-t1x9gknd 5915 16 once once RB cord-010119-t1x9gknd 5915 17 rare rare JJ cord-010119-t1x9gknd 5915 18 phenomenon phenomenon NN cord-010119-t1x9gknd 5915 19 of of IN cord-010119-t1x9gknd 5915 20 a a DT cord-010119-t1x9gknd 5915 21 M. M. NNP cord-010119-t1x9gknd 5915 22 pneumoniae pneumoniae NN cord-010119-t1x9gknd 5915 23 infection infection NN cord-010119-t1x9gknd 5915 24 associated associate VBN cord-010119-t1x9gknd 5915 25 with with IN cord-010119-t1x9gknd 5915 26 warm warm JJ cord-010119-t1x9gknd 5915 27 autoimmune autoimmune JJ cord-010119-t1x9gknd 5915 28 hemolytic hemolytic JJ cord-010119-t1x9gknd 5915 29 anemia anemia NN cord-010119-t1x9gknd 5915 30 may may MD cord-010119-t1x9gknd 5915 31 become become VB cord-010119-t1x9gknd 5915 32 a a DT cord-010119-t1x9gknd 5915 33 more more RBR cord-010119-t1x9gknd 5915 34 recognized recognize VBN cord-010119-t1x9gknd 5915 35 entity entity NN cord-010119-t1x9gknd 5915 36 . . . cord-010119-t1x9gknd 5915 37 ) ) -RRB- cord-010119-t1x9gknd 5916 1 and and CC cord-010119-t1x9gknd 5916 2 may may MD cord-010119-t1x9gknd 5916 3 serve serve VB cord-010119-t1x9gknd 5916 4 to to TO cord-010119-t1x9gknd 5916 5 more more RBR cord-010119-t1x9gknd 5916 6 reliably reliably RB cord-010119-t1x9gknd 5916 7 reflect reflect VB cord-010119-t1x9gknd 5916 8 when when WRB cord-010119-t1x9gknd 5916 9 the the DT cord-010119-t1x9gknd 5916 10 neonates neonate NNS cord-010119-t1x9gknd 5916 11 at at IN cord-010119-t1x9gknd 5916 12 risk risk NN cord-010119-t1x9gknd 5916 13 for for IN cord-010119-t1x9gknd 5916 14 hyperbilirubinemia hyperbilirubinemia NNP cord-010119-t1x9gknd 5916 15 . . . cord-010119-t1x9gknd 5917 1 The the DT cord-010119-t1x9gknd 5917 2 difficulty difficulty NN cord-010119-t1x9gknd 5917 3 in in IN cord-010119-t1x9gknd 5917 4 eliminating eliminate VBG cord-010119-t1x9gknd 5917 5 the the DT cord-010119-t1x9gknd 5917 6 cord cord NN cord-010119-t1x9gknd 5917 7 blood blood NN cord-010119-t1x9gknd 5917 8 testing testing NN cord-010119-t1x9gknd 5917 9 is be VBZ cord-010119-t1x9gknd 5917 10 the the DT cord-010119-t1x9gknd 5917 11 neonatologists neonatologist NNS cord-010119-t1x9gknd 5917 12 ' ' POS cord-010119-t1x9gknd 5917 13 reliance reliance NN cord-010119-t1x9gknd 5917 14 of of IN cord-010119-t1x9gknd 5917 15 using use VBG cord-010119-t1x9gknd 5917 16 ABO ABO NNP cord-010119-t1x9gknd 5917 17 incompatibility incompatibility NN cord-010119-t1x9gknd 5917 18 as as IN cord-010119-t1x9gknd 5917 19 part part NN cord-010119-t1x9gknd 5917 20 of of IN cord-010119-t1x9gknd 5917 21 the the DT cord-010119-t1x9gknd 5917 22 neonates neonate NNS cord-010119-t1x9gknd 5917 23 risk risk NN cord-010119-t1x9gknd 5917 24 assessment assessment NN cord-010119-t1x9gknd 5917 25 rather rather RB cord-010119-t1x9gknd 5917 26 than than IN cord-010119-t1x9gknd 5917 27 using use VBG cord-010119-t1x9gknd 5917 28 the the DT cord-010119-t1x9gknd 5917 29 point point NN cord-010119-t1x9gknd 5917 30 of of IN cord-010119-t1x9gknd 5917 31 care care NN cord-010119-t1x9gknd 5917 32 bilirubin bilirubin NN cord-010119-t1x9gknd 5917 33 testing testing NN cord-010119-t1x9gknd 5917 34 . . . cord-010119-t1x9gknd 5918 1 Currently currently RB cord-010119-t1x9gknd 5918 2 the the DT cord-010119-t1x9gknd 5918 3 TS TS NNP cord-010119-t1x9gknd 5918 4 requires require VBZ cord-010119-t1x9gknd 5918 5 all all DT cord-010119-t1x9gknd 5918 6 positive positive JJ cord-010119-t1x9gknd 5918 7 DAT DAT NNP cord-010119-t1x9gknd 5918 8 tests test NNS cord-010119-t1x9gknd 5918 9 to to TO cord-010119-t1x9gknd 5918 10 be be VB cord-010119-t1x9gknd 5918 11 communicated communicate VBN cord-010119-t1x9gknd 5918 12 to to IN cord-010119-t1x9gknd 5918 13 the the DT cord-010119-t1x9gknd 5918 14 nursing nursing NN cord-010119-t1x9gknd 5918 15 staff staff NN cord-010119-t1x9gknd 5918 16 immediately immediately RB cord-010119-t1x9gknd 5918 17 . . . cord-010119-t1x9gknd 5919 1 Given give VBN cord-010119-t1x9gknd 5919 2 that that IN cord-010119-t1x9gknd 5919 3 the the DT cord-010119-t1x9gknd 5919 4 DAT DAT NNP cord-010119-t1x9gknd 5919 5 strength strength NN cord-010119-t1x9gknd 5919 6 positively positively RB cord-010119-t1x9gknd 5919 7 correlates correlate VBZ cord-010119-t1x9gknd 5919 8 with with IN cord-010119-t1x9gknd 5919 9 the the DT cord-010119-t1x9gknd 5919 10 percentage percentage NN cord-010119-t1x9gknd 5919 11 of of IN cord-010119-t1x9gknd 5919 12 neonates neonate NNS cord-010119-t1x9gknd 5919 13 diagnosed diagnose VBN cord-010119-t1x9gknd 5919 14 with with IN cord-010119-t1x9gknd 5919 15 hyperbilirubinemia hyperbilirubinemia NNP cord-010119-t1x9gknd 5919 16 , , , cord-010119-t1x9gknd 5919 17 the the DT cord-010119-t1x9gknd 5919 18 TS TS NNP cord-010119-t1x9gknd 5919 19 staff staff NN cord-010119-t1x9gknd 5919 20 may may MD cord-010119-t1x9gknd 5919 21 also also RB cord-010119-t1x9gknd 5919 22 consider consider VB cord-010119-t1x9gknd 5919 23 notifying notify VBG cord-010119-t1x9gknd 5919 24 nursing nursing NN cord-010119-t1x9gknd 5919 25 staff staff NN cord-010119-t1x9gknd 5919 26 only only RB cord-010119-t1x9gknd 5919 27 for for IN cord-010119-t1x9gknd 5919 28 those those DT cord-010119-t1x9gknd 5919 29 patients patient NNS cord-010119-t1x9gknd 5919 30 whose whose WP$ cord-010119-t1x9gknd 5919 31 DAT DAT NNP cord-010119-t1x9gknd 5919 32 is be VBZ cord-010119-t1x9gknd 5919 33 3 3 CD cord-010119-t1x9gknd 5919 34 or or CC cord-010119-t1x9gknd 5919 35 41 41 CD cord-010119-t1x9gknd 5919 36 . . . cord-010119-t1x9gknd 5920 1 Platelet platelet NN cord-010119-t1x9gknd 5920 2 and and CC cord-010119-t1x9gknd 5920 3 Leukocyte Leukocyte NNP cord-010119-t1x9gknd 5920 4 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 5920 5 , , , cord-010119-t1x9gknd 5920 6 Testing Testing NNP cord-010119-t1x9gknd 5920 7 and and CC cord-010119-t1x9gknd 5920 8 Genetics Genetics NNP cord-010119-t1x9gknd 5920 9 Table Table NNP cord-010119-t1x9gknd 5920 10 1 1 CD cord-010119-t1x9gknd 5920 11 . . . cord-010119-t1x9gknd 5921 1 Of of IN cord-010119-t1x9gknd 5921 2 53 53 CD cord-010119-t1x9gknd 5921 3 pairs pair NNS cord-010119-t1x9gknd 5921 4 , , , cord-010119-t1x9gknd 5921 5 7 7 CD cord-010119-t1x9gknd 5921 6 pairs pair NNS cord-010119-t1x9gknd 5921 7 were be VBD cord-010119-t1x9gknd 5921 8 complete complete JJ cord-010119-t1x9gknd 5921 9 match match NN cord-010119-t1x9gknd 5921 10 ( ( -LRB- cord-010119-t1x9gknd 5921 11 2/2 2/2 CD cord-010119-t1x9gknd 5921 12 ) ) -RRB- cord-010119-t1x9gknd 5921 13 , , , cord-010119-t1x9gknd 5921 14 26 26 CD cord-010119-t1x9gknd 5921 15 pairs pair NNS cord-010119-t1x9gknd 5921 16 were be VBD cord-010119-t1x9gknd 5921 17 partial partial JJ cord-010119-t1x9gknd 5921 18 match match NN cord-010119-t1x9gknd 5921 19 ( ( -LRB- cord-010119-t1x9gknd 5921 20 1/2 1/2 CD cord-010119-t1x9gknd 5921 21 ) ) -RRB- cord-010119-t1x9gknd 5921 22 , , , cord-010119-t1x9gknd 5921 23 20 20 CD cord-010119-t1x9gknd 5921 24 pairs pair NNS cord-010119-t1x9gknd 5921 25 were be VBD cord-010119-t1x9gknd 5921 26 complete complete JJ cord-010119-t1x9gknd 5921 27 mismatch mismatch NN cord-010119-t1x9gknd 5921 28 ( ( -LRB- cord-010119-t1x9gknd 5921 29 0/2 0/2 CD cord-010119-t1x9gknd 5921 30 ) ) -RRB- cord-010119-t1x9gknd 5921 31 . . . cord-010119-t1x9gknd 5922 1 The the DT cord-010119-t1x9gknd 5922 2 matching matching JJ cord-010119-t1x9gknd 5922 3 rate rate NN cord-010119-t1x9gknd 5922 4 of of IN cord-010119-t1x9gknd 5922 5 HLA HLA NNP cord-010119-t1x9gknd 5922 6 - - HYPH cord-010119-t1x9gknd 5922 7 DPB1 DPB1 NNP cord-010119-t1x9gknd 5922 8 in in IN cord-010119-t1x9gknd 5922 9 our -PRON- PRP$ cord-010119-t1x9gknd 5922 10 study study NN cord-010119-t1x9gknd 5922 11 is be VBZ cord-010119-t1x9gknd 5922 12 13 13 CD cord-010119-t1x9gknd 5922 13 % % NN cord-010119-t1x9gknd 5922 14 . . . cord-010119-t1x9gknd 5923 1 Conclusion conclusion NN cord-010119-t1x9gknd 5923 2 : : : cord-010119-t1x9gknd 5924 1 The the DT cord-010119-t1x9gknd 5924 2 matching matching JJ cord-010119-t1x9gknd 5924 3 rate rate NN cord-010119-t1x9gknd 5924 4 of of IN cord-010119-t1x9gknd 5924 5 HLA HLA NNP cord-010119-t1x9gknd 5924 6 - - HYPH cord-010119-t1x9gknd 5924 7 DPB1 DPB1 NNP cord-010119-t1x9gknd 5924 8 in in IN cord-010119-t1x9gknd 5924 9 10/10 10/10 CD cord-010119-t1x9gknd 5924 10 HLA HLA NNP cord-010119-t1x9gknd 5924 11 matched match VBD cord-010119-t1x9gknd 5924 12 unrelated unrelated JJ cord-010119-t1x9gknd 5924 13 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 5924 14 stem stem NN cord-010119-t1x9gknd 5924 15 cell cell NN cord-010119-t1x9gknd 5924 16 transplantation transplantation NN cord-010119-t1x9gknd 5924 17 is be VBZ cord-010119-t1x9gknd 5924 18 low low JJ cord-010119-t1x9gknd 5924 19 and and CC cord-010119-t1x9gknd 5924 20 the the DT cord-010119-t1x9gknd 5924 21 gene gene NN cord-010119-t1x9gknd 5924 22 frequency frequency NN cord-010119-t1x9gknd 5924 23 of of IN cord-010119-t1x9gknd 5924 24 HLA HLA NNP cord-010119-t1x9gknd 5924 25 - - HYPH cord-010119-t1x9gknd 5924 26 DPB1 DPB1 NNP cord-010119-t1x9gknd 5924 27 in in IN cord-010119-t1x9gknd 5924 28 unrelated unrelated JJ cord-010119-t1x9gknd 5924 29 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 5924 30 stem stem NN cord-010119-t1x9gknd 5924 31 cell cell NN cord-010119-t1x9gknd 5924 32 transplantation transplantation NN cord-010119-t1x9gknd 5924 33 was be VBD cord-010119-t1x9gknd 5924 34 obtained obtain VBN cord-010119-t1x9gknd 5924 35 , , , cord-010119-t1x9gknd 5924 36 which which WDT cord-010119-t1x9gknd 5924 37 will will MD cord-010119-t1x9gknd 5924 38 help help VB cord-010119-t1x9gknd 5924 39 to to TO cord-010119-t1x9gknd 5924 40 study study VB cord-010119-t1x9gknd 5924 41 on on IN cord-010119-t1x9gknd 5924 42 the the DT cord-010119-t1x9gknd 5924 43 relationship relationship NN cord-010119-t1x9gknd 5924 44 between between IN cord-010119-t1x9gknd 5924 45 HLA HLA NNP cord-010119-t1x9gknd 5924 46 - - HYPH cord-010119-t1x9gknd 5924 47 DPB1 DPB1 NNP cord-010119-t1x9gknd 5924 48 and and CC cord-010119-t1x9gknd 5924 49 unrelated unrelated JJ cord-010119-t1x9gknd 5924 50 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 5924 51 stem stem NN cord-010119-t1x9gknd 5924 52 cell cell NN cord-010119-t1x9gknd 5924 53 transplantation transplantation NN cord-010119-t1x9gknd 5924 54 . . . cord-010119-t1x9gknd 5925 1 This this DT cord-010119-t1x9gknd 5925 2 work work NN cord-010119-t1x9gknd 5925 3 was be VBD cord-010119-t1x9gknd 5925 4 sponsored sponsor VBN cord-010119-t1x9gknd 5925 5 by by IN cord-010119-t1x9gknd 5925 6 National National NNP cord-010119-t1x9gknd 5925 7 Science Science NNP cord-010119-t1x9gknd 5925 8 Foundation Foundation NNP cord-010119-t1x9gknd 5925 9 of of IN cord-010119-t1x9gknd 5925 10 China China NNP cord-010119-t1x9gknd 5925 11 ( ( -LRB- cord-010119-t1x9gknd 5925 12 81401732 81401732 CD cord-010119-t1x9gknd 5925 13 ) ) -RRB- cord-010119-t1x9gknd 5926 1 Background Background NNP cord-010119-t1x9gknd 5926 2 / / SYM cord-010119-t1x9gknd 5926 3 Case Case NNP cord-010119-t1x9gknd 5926 4 Studies Studies NNPS cord-010119-t1x9gknd 5926 5 : : : cord-010119-t1x9gknd 5926 6 Thrombotic thrombotic JJ cord-010119-t1x9gknd 5926 7 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 5926 8 purpura purpura NN cord-010119-t1x9gknd 5926 9 ( ( -LRB- cord-010119-t1x9gknd 5926 10 TTP TTP NNP cord-010119-t1x9gknd 5926 11 ) ) -RRB- cord-010119-t1x9gknd 5926 12 is be VBZ cord-010119-t1x9gknd 5926 13 caused cause VBN cord-010119-t1x9gknd 5926 14 by by IN cord-010119-t1x9gknd 5926 15 severely severely RB cord-010119-t1x9gknd 5926 16 reduced reduce VBN cord-010119-t1x9gknd 5926 17 activity activity NN cord-010119-t1x9gknd 5926 18 of of IN cord-010119-t1x9gknd 5926 19 the the DT cord-010119-t1x9gknd 5926 20 von von NNP cord-010119-t1x9gknd 5926 21 Willebrand Willebrand NNP cord-010119-t1x9gknd 5926 22 factor factor NN cord-010119-t1x9gknd 5926 23 - - HYPH cord-010119-t1x9gknd 5926 24 cleaving cleave VBG cord-010119-t1x9gknd 5926 25 protease protease NN cord-010119-t1x9gknd 5926 26 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 5926 27 . . . cord-010119-t1x9gknd 5927 1 Therapeutic therapeutic JJ cord-010119-t1x9gknd 5927 2 plasma plasma NN cord-010119-t1x9gknd 5927 3 exchange exchange NN cord-010119-t1x9gknd 5927 4 ( ( -LRB- cord-010119-t1x9gknd 5927 5 TPE TPE NNP cord-010119-t1x9gknd 5927 6 ) ) -RRB- cord-010119-t1x9gknd 5927 7 as as RB cord-010119-t1x9gknd 5927 8 well well RB cord-010119-t1x9gknd 5927 9 as as IN cord-010119-t1x9gknd 5927 10 immunosuppression immunosuppression NN cord-010119-t1x9gknd 5927 11 minimize minimize VBP cord-010119-t1x9gknd 5927 12 the the DT cord-010119-t1x9gknd 5927 13 morbidity morbidity NN cord-010119-t1x9gknd 5927 14 and and CC cord-010119-t1x9gknd 5927 15 potential potential JJ cord-010119-t1x9gknd 5927 16 mortality mortality NN cord-010119-t1x9gknd 5927 17 of of IN cord-010119-t1x9gknd 5927 18 this this DT cord-010119-t1x9gknd 5927 19 presentation presentation NN cord-010119-t1x9gknd 5927 20 . . . cord-010119-t1x9gknd 5928 1 Absolute absolute JJ cord-010119-t1x9gknd 5928 2 Immature immature JJ cord-010119-t1x9gknd 5928 3 platelet platelet NN cord-010119-t1x9gknd 5928 4 counts count NNS cord-010119-t1x9gknd 5928 5 ( ( -LRB- cord-010119-t1x9gknd 5928 6 A A NNP cord-010119-t1x9gknd 5928 7 - - HYPH cord-010119-t1x9gknd 5928 8 IPC IPC NNP cord-010119-t1x9gknd 5928 9 ) ) -RRB- cord-010119-t1x9gknd 5928 10 have have VBP cord-010119-t1x9gknd 5928 11 been be VBN cord-010119-t1x9gknd 5928 12 shown show VBN cord-010119-t1x9gknd 5928 13 to to TO cord-010119-t1x9gknd 5928 14 help help VB cord-010119-t1x9gknd 5928 15 diagnose diagnose VB cord-010119-t1x9gknd 5928 16 and and CC cord-010119-t1x9gknd 5928 17 follow follow VB cord-010119-t1x9gknd 5928 18 TTP TTP NNP cord-010119-t1x9gknd 5928 19 patients patient NNS cord-010119-t1x9gknd 5928 20 ' ' POS cord-010119-t1x9gknd 5928 21 responses response NNS cord-010119-t1x9gknd 5928 22 to to IN cord-010119-t1x9gknd 5928 23 therapy therapy NN cord-010119-t1x9gknd 5928 24 . . . cord-010119-t1x9gknd 5929 1 We -PRON- PRP cord-010119-t1x9gknd 5929 2 report report VBP cord-010119-t1x9gknd 5929 3 the the DT cord-010119-t1x9gknd 5929 4 case case NN cord-010119-t1x9gknd 5929 5 of of IN cord-010119-t1x9gknd 5929 6 a a DT cord-010119-t1x9gknd 5929 7 man man NN cord-010119-t1x9gknd 5929 8 with with IN cord-010119-t1x9gknd 5929 9 relapsing relapse VBG cord-010119-t1x9gknd 5929 10 TTP ttp NN cord-010119-t1x9gknd 5929 11 , , , cord-010119-t1x9gknd 5929 12 low low JJ cord-010119-t1x9gknd 5929 13 ADAMTS13 adamts13 XX cord-010119-t1x9gknd 5929 14 with with IN cord-010119-t1x9gknd 5929 15 high high JJ cord-010119-t1x9gknd 5929 16 inhibitor inhibitor NN cord-010119-t1x9gknd 5929 17 , , , cord-010119-t1x9gknd 5929 18 treated treat VBN cord-010119-t1x9gknd 5929 19 with with IN cord-010119-t1x9gknd 5929 20 mycophenolate mycophenolate NNP cord-010119-t1x9gknd 5929 21 mofetil mofetil NNP cord-010119-t1x9gknd 5929 22 in in IN cord-010119-t1x9gknd 5929 23 which which WDT cord-010119-t1x9gknd 5929 24 A A NNP cord-010119-t1x9gknd 5929 25 - - HYPH cord-010119-t1x9gknd 5929 26 IPC IPC NNP cord-010119-t1x9gknd 5929 27 - - : cord-010119-t1x9gknd 5929 28 indicated indicate VBD cord-010119-t1x9gknd 5929 29 an an DT cord-010119-t1x9gknd 5929 30 unexpected unexpected JJ cord-010119-t1x9gknd 5929 31 response response NN cord-010119-t1x9gknd 5929 32 to to IN cord-010119-t1x9gknd 5929 33 therapy therapy NN cord-010119-t1x9gknd 5929 34 . . . cord-010119-t1x9gknd 5930 1 Study Study NNP cord-010119-t1x9gknd 5930 2 Design Design NNP cord-010119-t1x9gknd 5930 3 / / SYM cord-010119-t1x9gknd 5930 4 Method method NN cord-010119-t1x9gknd 5930 5 : : : cord-010119-t1x9gknd 5931 1 A a DT cord-010119-t1x9gknd 5931 2 56 56 CD cord-010119-t1x9gknd 5931 3 year year NN cord-010119-t1x9gknd 5931 4 old old JJ cord-010119-t1x9gknd 5931 5 male male NN cord-010119-t1x9gknd 5931 6 with with IN cord-010119-t1x9gknd 5931 7 a a DT cord-010119-t1x9gknd 5931 8 7-year 7-year CD cord-010119-t1x9gknd 5931 9 history history NN cord-010119-t1x9gknd 5931 10 of of IN cord-010119-t1x9gknd 5931 11 TTP TTP NNP cord-010119-t1x9gknd 5931 12 , , , cord-010119-t1x9gknd 5931 13 presented present VBN cord-010119-t1x9gknd 5931 14 with with IN cord-010119-t1x9gknd 5931 15 status status NN cord-010119-t1x9gknd 5931 16 epilepticus epilepticus NN cord-010119-t1x9gknd 5931 17 complicated complicate VBN cord-010119-t1x9gknd 5931 18 by by IN cord-010119-t1x9gknd 5931 19 acute acute JJ cord-010119-t1x9gknd 5931 20 respiratory respiratory JJ cord-010119-t1x9gknd 5931 21 failure failure NN cord-010119-t1x9gknd 5931 22 admitted admit VBN cord-010119-t1x9gknd 5931 23 with with IN cord-010119-t1x9gknd 5931 24 suspicion suspicion NN cord-010119-t1x9gknd 5931 25 for for IN cord-010119-t1x9gknd 5931 26 relapsing relapse VBG cord-010119-t1x9gknd 5931 27 TTP TTP NNP cord-010119-t1x9gknd 5931 28 . . . cord-010119-t1x9gknd 5932 1 Patient Patient NNP cord-010119-t1x9gknd 5932 2 had have VBD cord-010119-t1x9gknd 5932 3 been be VBN cord-010119-t1x9gknd 5932 4 treated treat VBN cord-010119-t1x9gknd 5932 5 in in IN cord-010119-t1x9gknd 5932 6 prior prior JJ cord-010119-t1x9gknd 5932 7 admissions admission NNS cord-010119-t1x9gknd 5932 8 with with IN cord-010119-t1x9gknd 5932 9 TPE TPE NNP cord-010119-t1x9gknd 5932 10 , , , cord-010119-t1x9gknd 5932 11 prednisolone prednisolone NN cord-010119-t1x9gknd 5932 12 , , , cord-010119-t1x9gknd 5932 13 rituximab rituximab NN cord-010119-t1x9gknd 5932 14 , , , cord-010119-t1x9gknd 5932 15 and and CC cord-010119-t1x9gknd 5932 16 cyclophosphamide cyclophosphamide RB cord-010119-t1x9gknd 5932 17 with with IN cord-010119-t1x9gknd 5932 18 clinical clinical JJ cord-010119-t1x9gknd 5932 19 improvement improvement NN cord-010119-t1x9gknd 5932 20 . . . cord-010119-t1x9gknd 5933 1 He -PRON- PRP cord-010119-t1x9gknd 5933 2 was be VBD cord-010119-t1x9gknd 5933 3 on on IN cord-010119-t1x9gknd 5933 4 mycophenolate mycophenolate NNP cord-010119-t1x9gknd 5933 5 mofetil mofetil NNP cord-010119-t1x9gknd 5933 6 maintenance maintenance NN cord-010119-t1x9gknd 5933 7 therapy therapy NN cord-010119-t1x9gknd 5933 8 which which WDT cord-010119-t1x9gknd 5933 9 he -PRON- PRP cord-010119-t1x9gknd 5933 10 last last RB cord-010119-t1x9gknd 5933 11 received receive VBD cord-010119-t1x9gknd 5933 12 just just RB cord-010119-t1x9gknd 5933 13 prior prior RB cord-010119-t1x9gknd 5933 14 to to IN cord-010119-t1x9gknd 5933 15 day day NN cord-010119-t1x9gknd 5933 16 of of IN cord-010119-t1x9gknd 5933 17 admission admission NN cord-010119-t1x9gknd 5933 18 due due IN cord-010119-t1x9gknd 5933 19 to to IN cord-010119-t1x9gknd 5933 20 consistently consistently RB cord-010119-t1x9gknd 5933 21 low low JJ cord-010119-t1x9gknd 5933 22 platelet platelet NN cord-010119-t1x9gknd 5933 23 counts count NNS cord-010119-t1x9gknd 5933 24 , , , cord-010119-t1x9gknd 5933 25 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 5933 26 < < XX cord-010119-t1x9gknd 5933 27 5 5 CD cord-010119-t1x9gknd 5933 28 % % NN cord-010119-t1x9gknd 5933 29 and and CC cord-010119-t1x9gknd 5933 30 inhibitor inhibitor NN cord-010119-t1x9gknd 5933 31 of of IN cord-010119-t1x9gknd 5933 32 3.6 3.6 CD cord-010119-t1x9gknd 5933 33 . . . cord-010119-t1x9gknd 5934 1 On on IN cord-010119-t1x9gknd 5934 2 day day NN cord-010119-t1x9gknd 5934 3 of of IN cord-010119-t1x9gknd 5934 4 admission admission NN cord-010119-t1x9gknd 5934 5 platelet platelet NN cord-010119-t1x9gknd 5934 6 count count NN cord-010119-t1x9gknd 5934 7 was be VBD cord-010119-t1x9gknd 5934 8 95 95 CD cord-010119-t1x9gknd 5934 9 x x SYM cord-010119-t1x9gknd 5934 10 10 10 CD cord-010119-t1x9gknd 5934 11 9 9 CD cord-010119-t1x9gknd 5934 12 /L /L , cord-010119-t1x9gknd 5934 13 which which WDT cord-010119-t1x9gknd 5934 14 decreased decrease VBD cord-010119-t1x9gknd 5934 15 within within IN cord-010119-t1x9gknd 5934 16 five five CD cord-010119-t1x9gknd 5934 17 days day NNS cord-010119-t1x9gknd 5934 18 to to IN cord-010119-t1x9gknd 5934 19 14 14 CD cord-010119-t1x9gknd 5934 20 x x SYM cord-010119-t1x9gknd 5934 21 10 10 CD cord-010119-t1x9gknd 5934 22 9 9 CD cord-010119-t1x9gknd 5934 23 /L /L . cord-010119-t1x9gknd 5934 24 leading lead VBG cord-010119-t1x9gknd 5934 25 to to IN cord-010119-t1x9gknd 5934 26 initiation initiation NN cord-010119-t1x9gknd 5934 27 of of IN cord-010119-t1x9gknd 5934 28 daily daily JJ cord-010119-t1x9gknd 5934 29 TPE TPE NNP cord-010119-t1x9gknd 5934 30 along along IN cord-010119-t1x9gknd 5934 31 with with IN cord-010119-t1x9gknd 5934 32 mycophenolate mycophenolate NNP cord-010119-t1x9gknd 5934 33 mofetil mofetil NNP cord-010119-t1x9gknd 5934 34 discontinuation discontinuation NN cord-010119-t1x9gknd 5934 35 just just RB cord-010119-t1x9gknd 5934 36 prior prior RB cord-010119-t1x9gknd 5934 37 to to IN cord-010119-t1x9gknd 5934 38 TPE TPE NNP cord-010119-t1x9gknd 5934 39 start start VB cord-010119-t1x9gknd 5934 40 . . . cord-010119-t1x9gknd 5935 1 Immature immature JJ cord-010119-t1x9gknd 5935 2 platelet platelet NN cord-010119-t1x9gknd 5935 3 fraction fraction NN cord-010119-t1x9gknd 5935 4 ( ( -LRB- cord-010119-t1x9gknd 5935 5 % % NN cord-010119-t1x9gknd 5935 6 -IPF -ipf CD cord-010119-t1x9gknd 5935 7 ) ) -RRB- cord-010119-t1x9gknd 5935 8 and and CC cord-010119-t1x9gknd 5935 9 calculated calculate VBD cord-010119-t1x9gknd 5935 10 A A NNP cord-010119-t1x9gknd 5935 11 - - HYPH cord-010119-t1x9gknd 5935 12 IPC IPC NNP cord-010119-t1x9gknd 5935 13 ( ( -LRB- cord-010119-t1x9gknd 5935 14 % % NN cord-010119-t1x9gknd 5935 15 -IPF -ipf SYM cord-010119-t1x9gknd 5935 16 x x SYM cord-010119-t1x9gknd 5935 17 platelet platelet NN cord-010119-t1x9gknd 5935 18 count count NN cord-010119-t1x9gknd 5935 19 ) ) -RRB- cord-010119-t1x9gknd 5935 20 were be VBD cord-010119-t1x9gknd 5935 21 obtained obtain VBN cord-010119-t1x9gknd 5935 22 with with IN cord-010119-t1x9gknd 5935 23 daily daily JJ cord-010119-t1x9gknd 5935 24 pre pre JJ cord-010119-t1x9gknd 5935 25 - - NNP cord-010119-t1x9gknd 5935 26 TPE TPE NNP cord-010119-t1x9gknd 5935 27 CBC CBC NNP cord-010119-t1x9gknd 5935 28 . . . cord-010119-t1x9gknd 5936 1 A a LS cord-010119-t1x9gknd 5936 2 - - HYPH cord-010119-t1x9gknd 5936 3 IPC IPC NNP cord-010119-t1x9gknd 5936 4 ratio ratio NN cord-010119-t1x9gknd 5936 5 was be VBD cord-010119-t1x9gknd 5936 6 calculated calculate VBN cord-010119-t1x9gknd 5936 7 from from IN cord-010119-t1x9gknd 5936 8 baseline baseline NN cord-010119-t1x9gknd 5936 9 . . . cord-010119-t1x9gknd 5937 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 5937 2 Results Results NNP cord-010119-t1x9gknd 5937 3 / / SYM cord-010119-t1x9gknd 5937 4 Finding finding NN cord-010119-t1x9gknd 5937 5 : : : cord-010119-t1x9gknd 5938 1 A a LS cord-010119-t1x9gknd 5938 2 - - HYPH cord-010119-t1x9gknd 5938 3 IPC IPC NNP cord-010119-t1x9gknd 5938 4 and and CC cord-010119-t1x9gknd 5938 5 platelet platelet NN cord-010119-t1x9gknd 5938 6 count count NN cord-010119-t1x9gknd 5938 7 were be VBD cord-010119-t1x9gknd 5938 8 1 1 CD cord-010119-t1x9gknd 5938 9 x x SYM cord-010119-t1x9gknd 5938 10 10 10 CD cord-010119-t1x9gknd 5938 11 9 9 CD cord-010119-t1x9gknd 5938 12 /L /l CD cord-010119-t1x9gknd 5938 13 and and CC cord-010119-t1x9gknd 5938 14 14 14 CD cord-010119-t1x9gknd 5938 15 x x SYM cord-010119-t1x9gknd 5938 16 10 10 CD cord-010119-t1x9gknd 5938 17 9 9 CD cord-010119-t1x9gknd 5938 18 /L /L . cord-010119-t1x9gknd 5938 19 respectively respectively RB cord-010119-t1x9gknd 5938 20 . . . cord-010119-t1x9gknd 5939 1 Counts count NNS cord-010119-t1x9gknd 5939 2 improved improve VBD cord-010119-t1x9gknd 5939 3 rapidly rapidly RB cord-010119-t1x9gknd 5939 4 post post JJ cord-010119-t1x9gknd 5939 5 - - JJ cord-010119-t1x9gknd 5939 6 TPE tpe JJ cord-010119-t1x9gknd 5939 7 initiation initiation NN cord-010119-t1x9gknd 5939 8 and and CC cord-010119-t1x9gknd 5939 9 after after IN cord-010119-t1x9gknd 5939 10 one one CD cord-010119-t1x9gknd 5939 11 TPE tpe NN cord-010119-t1x9gknd 5940 1 his -PRON- PRP$ cord-010119-t1x9gknd 5940 2 A A NNP cord-010119-t1x9gknd 5940 3 - - HYPH cord-010119-t1x9gknd 5940 4 IPC IPC NNP cord-010119-t1x9gknd 5940 5 tripled triple VBD cord-010119-t1x9gknd 5940 6 to to IN cord-010119-t1x9gknd 5940 7 3.2 3.2 CD cord-010119-t1x9gknd 5940 8 x x SYM cord-010119-t1x9gknd 5940 9 10 10 CD cord-010119-t1x9gknd 5940 10 9 9 CD cord-010119-t1x9gknd 5940 11 /L /L . cord-010119-t1x9gknd 5940 12 achieving achieve VBG cord-010119-t1x9gknd 5940 13 the the DT cord-010119-t1x9gknd 5940 14 ratio ratio NN cord-010119-t1x9gknd 5940 15 of of IN cord-010119-t1x9gknd 5940 16 3 3 CD cord-010119-t1x9gknd 5940 17 previously previously RB cord-010119-t1x9gknd 5940 18 shown show VBN cord-010119-t1x9gknd 5940 19 to to TO cord-010119-t1x9gknd 5940 20 be be VB cord-010119-t1x9gknd 5940 21 diagnostic diagnostic JJ cord-010119-t1x9gknd 5940 22 of of IN cord-010119-t1x9gknd 5940 23 TTP TTP NNP cord-010119-t1x9gknd 5940 24 . . . cord-010119-t1x9gknd 5941 1 On on IN cord-010119-t1x9gknd 5941 2 day day NN cord-010119-t1x9gknd 5941 3 5 5 CD cord-010119-t1x9gknd 5941 4 his -PRON- PRP$ cord-010119-t1x9gknd 5941 5 A A NNP cord-010119-t1x9gknd 5941 6 - - HYPH cord-010119-t1x9gknd 5941 7 IPC ipc NN cord-010119-t1x9gknd 5941 8 and and CC cord-010119-t1x9gknd 5941 9 platelet platelet NN cord-010119-t1x9gknd 5941 10 counts count NNS cord-010119-t1x9gknd 5941 11 had have VBD cord-010119-t1x9gknd 5941 12 improved improve VBN cord-010119-t1x9gknd 5941 13 to to IN cord-010119-t1x9gknd 5941 14 7.5 7.5 CD cord-010119-t1x9gknd 5941 15 x x SYM cord-010119-t1x9gknd 5941 16 10 10 CD cord-010119-t1x9gknd 5941 17 9 9 CD cord-010119-t1x9gknd 5941 18 /L /L , cord-010119-t1x9gknd 5941 19 and and CC cord-010119-t1x9gknd 5941 20 218 218 CD cord-010119-t1x9gknd 5941 21 x x SYM cord-010119-t1x9gknd 5941 22 10 10 CD cord-010119-t1x9gknd 5941 23 9 9 CD cord-010119-t1x9gknd 5941 24 /L /L . cord-010119-t1x9gknd 5941 25 respectively respectively RB cord-010119-t1x9gknd 5941 26 . . . cord-010119-t1x9gknd 5942 1 Absence absence NN cord-010119-t1x9gknd 5942 2 of of IN cord-010119-t1x9gknd 5942 3 anti anti JJ cord-010119-t1x9gknd 5942 4 - - JJ cord-010119-t1x9gknd 5942 5 PF4 pf4 JJ cord-010119-t1x9gknd 5942 6 antibodies antibody NNS cord-010119-t1x9gknd 5942 7 ruled rule VBD cord-010119-t1x9gknd 5942 8 out out RP cord-010119-t1x9gknd 5942 9 heparin heparin NN cord-010119-t1x9gknd 5942 10 - - HYPH cord-010119-t1x9gknd 5942 11 induced induce VBN cord-010119-t1x9gknd 5942 12 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 5942 13 at at IN cord-010119-t1x9gknd 5942 14 this this DT cord-010119-t1x9gknd 5942 15 time time NN cord-010119-t1x9gknd 5942 16 . . . cord-010119-t1x9gknd 5943 1 On on IN cord-010119-t1x9gknd 5943 2 day day NN cord-010119-t1x9gknd 5943 3 6 6 CD cord-010119-t1x9gknd 5943 4 he -PRON- PRP cord-010119-t1x9gknd 5943 5 had have VBD cord-010119-t1x9gknd 5943 6 an an DT cord-010119-t1x9gknd 5943 7 unexpected unexpected JJ cord-010119-t1x9gknd 5943 8 decrease decrease NN cord-010119-t1x9gknd 5943 9 in in IN cord-010119-t1x9gknd 5943 10 both both CC cord-010119-t1x9gknd 5943 11 A A NNP cord-010119-t1x9gknd 5943 12 - - HYPH cord-010119-t1x9gknd 5943 13 IPC IPC NNP cord-010119-t1x9gknd 5943 14 and and CC cord-010119-t1x9gknd 5943 15 platelet platelet NN cord-010119-t1x9gknd 5943 16 count count NN cord-010119-t1x9gknd 5943 17 to to IN cord-010119-t1x9gknd 5943 18 4.8 4.8 CD cord-010119-t1x9gknd 5943 19 x x SYM cord-010119-t1x9gknd 5943 20 10 10 CD cord-010119-t1x9gknd 5943 21 9 9 CD cord-010119-t1x9gknd 5943 22 /L /L , cord-010119-t1x9gknd 5943 23 and and CC cord-010119-t1x9gknd 5943 24 132 132 CD cord-010119-t1x9gknd 5943 25 x x SYM cord-010119-t1x9gknd 5943 26 10 10 CD cord-010119-t1x9gknd 5943 27 9 9 CD cord-010119-t1x9gknd 5943 28 /L /L . cord-010119-t1x9gknd 5943 29 respectively respectively RB cord-010119-t1x9gknd 5943 30 , , , cord-010119-t1x9gknd 5943 31 worsening worsen VBG cord-010119-t1x9gknd 5943 32 by by IN cord-010119-t1x9gknd 5943 33 day day NN cord-010119-t1x9gknd 5943 34 8 8 CD cord-010119-t1x9gknd 5943 35 to to TO cord-010119-t1x9gknd 5943 36 1.7 1.7 CD cord-010119-t1x9gknd 5943 37 x x SYM cord-010119-t1x9gknd 5943 38 10 10 CD cord-010119-t1x9gknd 5943 39 9 9 CD cord-010119-t1x9gknd 5943 40 /L /L . cord-010119-t1x9gknd 5943 41 and and CC cord-010119-t1x9gknd 5943 42 40 40 CD cord-010119-t1x9gknd 5943 43 x x SYM cord-010119-t1x9gknd 5943 44 10 10 CD cord-010119-t1x9gknd 5943 45 9 9 CD cord-010119-t1x9gknd 5943 46 /L /L . cord-010119-t1x9gknd 5943 47 respectively respectively RB cord-010119-t1x9gknd 5943 48 despite despite IN cord-010119-t1x9gknd 5943 49 daily daily JJ cord-010119-t1x9gknd 5943 50 TPE TPE NNP cord-010119-t1x9gknd 5943 51 . . . cord-010119-t1x9gknd 5944 1 Patient Patient NNP cord-010119-t1x9gknd 5944 2 received receive VBD cord-010119-t1x9gknd 5944 3 25 25 CD cord-010119-t1x9gknd 5944 4 additional additional JJ cord-010119-t1x9gknd 5944 5 TPEs tpe NNS cord-010119-t1x9gknd 5944 6 that that WDT cord-010119-t1x9gknd 5944 7 failed fail VBD cord-010119-t1x9gknd 5944 8 to to TO cord-010119-t1x9gknd 5944 9 improve improve VB cord-010119-t1x9gknd 5944 10 A A NNP cord-010119-t1x9gknd 5944 11 - - HYPH cord-010119-t1x9gknd 5944 12 IPC IPC NNP cord-010119-t1x9gknd 5944 13 or or CC cord-010119-t1x9gknd 5944 14 platelets platelet NNS cord-010119-t1x9gknd 5944 15 which which WDT cord-010119-t1x9gknd 5944 16 on on IN cord-010119-t1x9gknd 5944 17 day day NN cord-010119-t1x9gknd 5944 18 32 32 CD cord-010119-t1x9gknd 5944 19 were be VBD cord-010119-t1x9gknd 5944 20 0.4 0.4 CD cord-010119-t1x9gknd 5944 21 x x SYM cord-010119-t1x9gknd 5944 22 10 10 CD cord-010119-t1x9gknd 5944 23 9 9 CD cord-010119-t1x9gknd 5944 24 /L /l CD cord-010119-t1x9gknd 5944 25 and and CC cord-010119-t1x9gknd 5944 26 13 13 CD cord-010119-t1x9gknd 5944 27 x x SYM cord-010119-t1x9gknd 5944 28 10 10 CD cord-010119-t1x9gknd 5944 29 9 9 CD cord-010119-t1x9gknd 5944 30 /L /L . cord-010119-t1x9gknd 5944 31 respectively respectively RB cord-010119-t1x9gknd 5944 32 . . . cord-010119-t1x9gknd 5945 1 A a LS cord-010119-t1x9gknd 5945 2 - - HYPH cord-010119-t1x9gknd 5945 3 IPC IPC NNP cord-010119-t1x9gknd 5945 4 had have VBD cord-010119-t1x9gknd 5945 5 remained remain VBN cord-010119-t1x9gknd 5945 6 at at IN cord-010119-t1x9gknd 5945 7 this this DT cord-010119-t1x9gknd 5945 8 level level NN cord-010119-t1x9gknd 5945 9 for for IN cord-010119-t1x9gknd 5945 10 16 16 CD cord-010119-t1x9gknd 5945 11 days day NNS cord-010119-t1x9gknd 5945 12 suggesting suggest VBG cord-010119-t1x9gknd 5945 13 that that IN cord-010119-t1x9gknd 5945 14 the the DT cord-010119-t1x9gknd 5945 15 observed observed JJ cord-010119-t1x9gknd 5945 16 decrease decrease NN cord-010119-t1x9gknd 5945 17 was be VBD cord-010119-t1x9gknd 5945 18 irreversible irreversible JJ cord-010119-t1x9gknd 5945 19 . . . cord-010119-t1x9gknd 5946 1 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 5946 2 activity activity NN cord-010119-t1x9gknd 5946 3 remained remain VBD cord-010119-t1x9gknd 5946 4 < < XX cord-010119-t1x9gknd 5946 5 5 5 CD cord-010119-t1x9gknd 5946 6 % % NN cord-010119-t1x9gknd 5946 7 low low JJ cord-010119-t1x9gknd 5946 8 with with IN cord-010119-t1x9gknd 5946 9 a a DT cord-010119-t1x9gknd 5946 10 high high JJ cord-010119-t1x9gknd 5946 11 inhibitor inhibitor NN cord-010119-t1x9gknd 5946 12 . . . cord-010119-t1x9gknd 5947 1 Patient Patient NNP cord-010119-t1x9gknd 5947 2 's 's POS cord-010119-t1x9gknd 5947 3 clinical clinical JJ cord-010119-t1x9gknd 5947 4 condition condition NN cord-010119-t1x9gknd 5947 5 continued continue VBD cord-010119-t1x9gknd 5947 6 to to TO cord-010119-t1x9gknd 5947 7 deteriorate deteriorate VB cord-010119-t1x9gknd 5947 8 and and CC cord-010119-t1x9gknd 5947 9 family family NN cord-010119-t1x9gknd 5947 10 placed place VBD cord-010119-t1x9gknd 5947 11 patient patient NN cord-010119-t1x9gknd 5947 12 on on IN cord-010119-t1x9gknd 5947 13 comfort comfort NN cord-010119-t1x9gknd 5947 14 care care NN cord-010119-t1x9gknd 5947 15 . . . cord-010119-t1x9gknd 5948 1 Conclusion conclusion NN cord-010119-t1x9gknd 5948 2 : : : cord-010119-t1x9gknd 5949 1 TTP TTP NNP cord-010119-t1x9gknd 5949 2 patients patient NNS cord-010119-t1x9gknd 5949 3 have have VBP cord-010119-t1x9gknd 5949 4 low low JJ cord-010119-t1x9gknd 5949 5 A A NNP cord-010119-t1x9gknd 5949 6 - - HYPH cord-010119-t1x9gknd 5949 7 IPC IPC NNP cord-010119-t1x9gknd 5949 8 and and CC cord-010119-t1x9gknd 5949 9 PLT PLT NNP cord-010119-t1x9gknd 5949 10 counts count VBZ cord-010119-t1x9gknd 5949 11 at at IN cord-010119-t1x9gknd 5949 12 presentation presentation NN cord-010119-t1x9gknd 5949 13 , , , cord-010119-t1x9gknd 5949 14 with with IN cord-010119-t1x9gknd 5949 15 the the DT cord-010119-t1x9gknd 5949 16 former former JJ cord-010119-t1x9gknd 5949 17 improving improve VBG cord-010119-t1x9gknd 5949 18 first first JJ cord-010119-t1x9gknd 5949 19 post post JJ cord-010119-t1x9gknd 5949 20 - - JJ cord-010119-t1x9gknd 5949 21 TPE tpe JJ cord-010119-t1x9gknd 5949 22 initiation initiation NN cord-010119-t1x9gknd 5949 23 . . . cord-010119-t1x9gknd 5950 1 Despite despite IN cord-010119-t1x9gknd 5950 2 appropriate appropriate JJ cord-010119-t1x9gknd 5950 3 therapy therapy NN cord-010119-t1x9gknd 5950 4 leading lead VBG cord-010119-t1x9gknd 5950 5 to to IN cord-010119-t1x9gknd 5950 6 early early JJ cord-010119-t1x9gknd 5950 7 improvement improvement NN cord-010119-t1x9gknd 5950 8 of of IN cord-010119-t1x9gknd 5950 9 platelet platelet NN cord-010119-t1x9gknd 5950 10 count count NN cord-010119-t1x9gknd 5950 11 , , , cord-010119-t1x9gknd 5950 12 patient patient NNP cord-010119-t1x9gknd 5950 13 's 's POS cord-010119-t1x9gknd 5950 14 counts count NNS cord-010119-t1x9gknd 5950 15 declined decline VBD cord-010119-t1x9gknd 5950 16 rapidly rapidly RB cord-010119-t1x9gknd 5950 17 leading lead VBG cord-010119-t1x9gknd 5950 18 to to IN cord-010119-t1x9gknd 5950 19 suspicion suspicion NN cord-010119-t1x9gknd 5950 20 for for IN cord-010119-t1x9gknd 5950 21 platelet platelet NN cord-010119-t1x9gknd 5950 22 production production NN cord-010119-t1x9gknd 5950 23 suppression suppression NN cord-010119-t1x9gknd 5950 24 as as IN cord-010119-t1x9gknd 5950 25 indicated indicate VBN cord-010119-t1x9gknd 5950 26 by by IN cord-010119-t1x9gknd 5950 27 the the DT cord-010119-t1x9gknd 5950 28 sustained sustained JJ cord-010119-t1x9gknd 5950 29 very very RB cord-010119-t1x9gknd 5950 30 low low JJ cord-010119-t1x9gknd 5950 31 A A NNP cord-010119-t1x9gknd 5950 32 - - HYPH cord-010119-t1x9gknd 5950 33 IPC IPC NNP cord-010119-t1x9gknd 5950 34 . . . cord-010119-t1x9gknd 5951 1 In in IN cord-010119-t1x9gknd 5951 2 the the DT cord-010119-t1x9gknd 5951 3 setting setting NN cord-010119-t1x9gknd 5951 4 of of IN cord-010119-t1x9gknd 5951 5 TTP TTP NNP cord-010119-t1x9gknd 5951 6 , , , cord-010119-t1x9gknd 5951 7 or or CC cord-010119-t1x9gknd 5951 8 relapsing relapse VBG cord-010119-t1x9gknd 5951 9 TTP TTP NNP cord-010119-t1x9gknd 5951 10 use use NN cord-010119-t1x9gknd 5951 11 of of IN cord-010119-t1x9gknd 5951 12 immunosuppression immunosuppression NN cord-010119-t1x9gknd 5951 13 should should MD cord-010119-t1x9gknd 5951 14 be be VB cord-010119-t1x9gknd 5951 15 closely closely RB cord-010119-t1x9gknd 5951 16 followed follow VBN cord-010119-t1x9gknd 5951 17 and and CC cord-010119-t1x9gknd 5951 18 A A NNP cord-010119-t1x9gknd 5951 19 - - HYPH cord-010119-t1x9gknd 5951 20 IPC IPC NNP cord-010119-t1x9gknd 5951 21 may may MD cord-010119-t1x9gknd 5951 22 aid aid VB cord-010119-t1x9gknd 5951 23 in in IN cord-010119-t1x9gknd 5951 24 establishing establish VBG cord-010119-t1x9gknd 5951 25 early early RB cord-010119-t1x9gknd 5951 26 if if IN cord-010119-t1x9gknd 5951 27 therapy therapy NN cord-010119-t1x9gknd 5951 28 is be VBZ cord-010119-t1x9gknd 5951 29 affecting affect VBG cord-010119-t1x9gknd 5951 30 platelet platelet NN cord-010119-t1x9gknd 5951 31 production production NN cord-010119-t1x9gknd 5951 32 . . . cord-010119-t1x9gknd 5952 1 Application application NN cord-010119-t1x9gknd 5952 2 of of IN cord-010119-t1x9gknd 5952 3 Luminex Luminex NNP cord-010119-t1x9gknd 5952 4 Bead Bead NNP cord-010119-t1x9gknd 5952 5 Technology Technology NNP cord-010119-t1x9gknd 5952 6 to to TO cord-010119-t1x9gknd 5952 7 Detect detect VB cord-010119-t1x9gknd 5952 8 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5952 9 , , , cord-010119-t1x9gknd 5952 10 HPA-3a HPA-3a NNP cord-010119-t1x9gknd 5952 11 , , , cord-010119-t1x9gknd 5952 12 and and CC cord-010119-t1x9gknd 5952 13 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 5952 14 Antibodies Antibodies NNPS cord-010119-t1x9gknd 5953 1 Su Su NNP cord-010119-t1x9gknd 5953 2 - - HYPH cord-010119-t1x9gknd 5953 3 dan dan NNP cord-010119-t1x9gknd 5953 4 Tao Tao NNP cord-010119-t1x9gknd 5954 1 * * NFP cord-010119-t1x9gknd 5955 1 , , , cord-010119-t1x9gknd 5955 2 Ying Ying NNP cord-010119-t1x9gknd 5955 3 Liu Liu NNP cord-010119-t1x9gknd 5955 4 , , , cord-010119-t1x9gknd 5956 1 Yan Yan NNP cord-010119-t1x9gknd 5956 2 - - HYPH cord-010119-t1x9gknd 5956 3 min min NNP cord-010119-t1x9gknd 5956 4 He He NNP cord-010119-t1x9gknd 5956 5 , , , cord-010119-t1x9gknd 5956 6 Ji Ji NNP cord-010119-t1x9gknd 5956 7 He He NNP cord-010119-t1x9gknd 5956 8 and and CC cord-010119-t1x9gknd 5956 9 Fa Fa NNP cord-010119-t1x9gknd 5956 10 - - HYPH cord-010119-t1x9gknd 5956 11 Ming Ming NNP cord-010119-t1x9gknd 5956 12 Zhu Zhu NNP cord-010119-t1x9gknd 5956 13 . . . cord-010119-t1x9gknd 5957 1 Blood Blood NNP cord-010119-t1x9gknd 5957 2 Center Center NNP cord-010119-t1x9gknd 5957 3 of of IN cord-010119-t1x9gknd 5957 4 Zhejiang Zhejiang NNP cord-010119-t1x9gknd 5957 5 Province Province NNP cord-010119-t1x9gknd 5957 6 , , , cord-010119-t1x9gknd 5957 7 Key Key NNP cord-010119-t1x9gknd 5957 8 Laboratory Laboratory NNP cord-010119-t1x9gknd 5957 9 of of IN cord-010119-t1x9gknd 5957 10 Blood Blood NNP cord-010119-t1x9gknd 5957 11 Safety Safety NNP cord-010119-t1x9gknd 5957 12 Research Research NNP cord-010119-t1x9gknd 5957 13 , , , cord-010119-t1x9gknd 5958 1 Ministry Ministry NNP cord-010119-t1x9gknd 5958 2 of of IN cord-010119-t1x9gknd 5958 3 Health Health NNP cord-010119-t1x9gknd 5958 4 Background Background NNP cord-010119-t1x9gknd 5958 5 / / SYM cord-010119-t1x9gknd 5958 6 Case Case NNP cord-010119-t1x9gknd 5958 7 Studies Studies NNPS cord-010119-t1x9gknd 5958 8 : : : cord-010119-t1x9gknd 5958 9 Detection detection NN cord-010119-t1x9gknd 5958 10 of of IN cord-010119-t1x9gknd 5958 11 antibodies antibody NNS cord-010119-t1x9gknd 5958 12 against against IN cord-010119-t1x9gknd 5958 13 human human JJ cord-010119-t1x9gknd 5958 14 platelet platelet NN cord-010119-t1x9gknd 5958 15 antigens antigen NNS cord-010119-t1x9gknd 5958 16 ( ( -LRB- cord-010119-t1x9gknd 5958 17 HPAs HPAs NNP cord-010119-t1x9gknd 5958 18 ) ) -RRB- cord-010119-t1x9gknd 5958 19 is be VBZ cord-010119-t1x9gknd 5958 20 crucial crucial JJ cord-010119-t1x9gknd 5958 21 for for IN cord-010119-t1x9gknd 5958 22 patients patient NNS cord-010119-t1x9gknd 5958 23 ' ' POS cord-010119-t1x9gknd 5958 24 refractory refractory JJ cord-010119-t1x9gknd 5958 25 to to IN cord-010119-t1x9gknd 5958 26 platelet platelet NN cord-010119-t1x9gknd 5958 27 transfusion transfusion NN cord-010119-t1x9gknd 5958 28 therapy therapy NN cord-010119-t1x9gknd 5958 29 . . . cord-010119-t1x9gknd 5959 1 In in IN cord-010119-t1x9gknd 5959 2 the the DT cord-010119-t1x9gknd 5959 3 text text NN cord-010119-t1x9gknd 5959 4 , , , cord-010119-t1x9gknd 5959 5 Luminex Luminex NNP cord-010119-t1x9gknd 5959 6 bead bead NN cord-010119-t1x9gknd 5959 7 coupled couple VBN cord-010119-t1x9gknd 5959 8 with with IN cord-010119-t1x9gknd 5959 9 anti anti JJ cord-010119-t1x9gknd 5959 10 - - JJ cord-010119-t1x9gknd 5959 11 GPIIb GPIIb NNS cord-010119-t1x9gknd 5959 12 / / SYM cord-010119-t1x9gknd 5959 13 IIIa IIIa NNS cord-010119-t1x9gknd 5959 14 and and CC cord-010119-t1x9gknd 5959 15 anti anti NNS cord-010119-t1x9gknd 5959 16 - - JJ cord-010119-t1x9gknd 5959 17 GPIa GPIa NNPS cord-010119-t1x9gknd 5959 18 / / SYM cord-010119-t1x9gknd 5959 19 IIa IIa NNP cord-010119-t1x9gknd 5959 20 monoclonal monoclonal JJ cord-010119-t1x9gknd 5959 21 antibody antibody NN cord-010119-t1x9gknd 5959 22 was be VBD cord-010119-t1x9gknd 5959 23 implied imply VBN cord-010119-t1x9gknd 5959 24 to to TO cord-010119-t1x9gknd 5959 25 detect detect VB cord-010119-t1x9gknd 5960 1 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5960 2 , , , cord-010119-t1x9gknd 5960 3 HPA-3a HPA-3a NNP cord-010119-t1x9gknd 5960 4 , , , cord-010119-t1x9gknd 5960 5 and and CC cord-010119-t1x9gknd 5960 6 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 5960 7 antibodies antibody NNS cord-010119-t1x9gknd 5960 8 , , , cord-010119-t1x9gknd 5960 9 and and CC cord-010119-t1x9gknd 5960 10 the the DT cord-010119-t1x9gknd 5960 11 sensitivity sensitivity NN cord-010119-t1x9gknd 5960 12 of of IN cord-010119-t1x9gknd 5960 13 Luminex Luminex NNP cord-010119-t1x9gknd 5960 14 bead bead NN cord-010119-t1x9gknd 5960 15 technology technology NN cord-010119-t1x9gknd 5960 16 was be VBD cord-010119-t1x9gknd 5960 17 compared compare VBN cord-010119-t1x9gknd 5960 18 with with IN cord-010119-t1x9gknd 5960 19 monoclonal monoclonal JJ cord-010119-t1x9gknd 5960 20 antibody antibody NN cord-010119-t1x9gknd 5960 21 immobilization immobilization NN cord-010119-t1x9gknd 5960 22 of of IN cord-010119-t1x9gknd 5960 23 platelet platelet NN cord-010119-t1x9gknd 5960 24 antigens antigen NNS cord-010119-t1x9gknd 5960 25 ( ( -LRB- cord-010119-t1x9gknd 5960 26 MAIPA MAIPA NNP cord-010119-t1x9gknd 5960 27 ) ) -RRB- cord-010119-t1x9gknd 5960 28 assay assay NN cord-010119-t1x9gknd 5960 29 . . . cord-010119-t1x9gknd 5961 1 Study Study NNP cord-010119-t1x9gknd 5961 2 Design Design NNP cord-010119-t1x9gknd 5961 3 / / SYM cord-010119-t1x9gknd 5961 4 Method method NN cord-010119-t1x9gknd 5961 5 : : : cord-010119-t1x9gknd 5961 6 Monoclonal Monoclonal NNP cord-010119-t1x9gknd 5961 7 antibodies antibody NNS cord-010119-t1x9gknd 5961 8 P2 P2 NNP cord-010119-t1x9gknd 5961 9 and and CC cord-010119-t1x9gknd 5961 10 Gi9 gi9 NN cord-010119-t1x9gknd 5961 11 , , , cord-010119-t1x9gknd 5961 12 specific specific JJ cord-010119-t1x9gknd 5961 13 for for IN cord-010119-t1x9gknd 5961 14 platelet platelet NN cord-010119-t1x9gknd 5961 15 glycoproteins glycoprotein NNS cord-010119-t1x9gknd 5961 16 GPIIb GPIIb NNP cord-010119-t1x9gknd 5961 17 / / SYM cord-010119-t1x9gknd 5961 18 IIIa IIIa NNS cord-010119-t1x9gknd 5961 19 and and CC cord-010119-t1x9gknd 5961 20 GPIa GPIa NNPS cord-010119-t1x9gknd 5961 21 / / SYM cord-010119-t1x9gknd 5961 22 IIa IIa NNP cord-010119-t1x9gknd 5961 23 , , , cord-010119-t1x9gknd 5961 24 were be VBD cord-010119-t1x9gknd 5961 25 separately separately RB cord-010119-t1x9gknd 5961 26 coupled couple VBN cord-010119-t1x9gknd 5961 27 to to IN cord-010119-t1x9gknd 5961 28 Luminex Luminex NNP cord-010119-t1x9gknd 5961 29 xMAP xmap IN cord-010119-t1x9gknd 5961 30 beads bead NNS cord-010119-t1x9gknd 5961 31 . . . cord-010119-t1x9gknd 5962 1 Four four CD cord-010119-t1x9gknd 5962 2 standard standard JJ cord-010119-t1x9gknd 5962 3 sera sera NNP cord-010119-t1x9gknd 5962 4 , , , cord-010119-t1x9gknd 5962 5 containing contain VBG cord-010119-t1x9gknd 5962 6 anti anti NNP cord-010119-t1x9gknd 5962 7 - - NNP cord-010119-t1x9gknd 5962 8 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5962 9 , , , cord-010119-t1x9gknd 5962 10 anti anti NNP cord-010119-t1x9gknd 5962 11 - - NNP cord-010119-t1x9gknd 5962 12 HPA-3a hpa-3a JJ cord-010119-t1x9gknd 5962 13 , , , cord-010119-t1x9gknd 5962 14 anti anti JJ cord-010119-t1x9gknd 5962 15 - - JJ cord-010119-t1x9gknd 5962 16 HPA-5a hpa-5a JJ cord-010119-t1x9gknd 5962 17 and and CC cord-010119-t1x9gknd 5962 18 anti anti NNS cord-010119-t1x9gknd 5962 19 - - NN cord-010119-t1x9gknd 5962 20 HPA-5b HPA-5b NNP cord-010119-t1x9gknd 5962 21 respectively respectively RB cord-010119-t1x9gknd 5962 22 , , , cord-010119-t1x9gknd 5962 23 were be VBD cord-010119-t1x9gknd 5962 24 bought buy VBN cord-010119-t1x9gknd 5962 25 from from IN cord-010119-t1x9gknd 5962 26 NIBSC NIBSC NNP cord-010119-t1x9gknd 5962 27 ; ; : cord-010119-t1x9gknd 5962 28 three three CD cord-010119-t1x9gknd 5962 29 negative negative JJ cord-010119-t1x9gknd 5962 30 sera sera NNP cord-010119-t1x9gknd 5962 31 without without IN cord-010119-t1x9gknd 5962 32 HPA HPA NNP cord-010119-t1x9gknd 5962 33 antibodies antibody NNS cord-010119-t1x9gknd 5962 34 were be VBD cord-010119-t1x9gknd 5962 35 prepared prepare VBN cord-010119-t1x9gknd 5962 36 from from IN cord-010119-t1x9gknd 5962 37 AB AB NNP cord-010119-t1x9gknd 5962 38 type type NN cord-010119-t1x9gknd 5962 39 blood blood NN cord-010119-t1x9gknd 5962 40 donors donor NNS cord-010119-t1x9gknd 5962 41 . . . cord-010119-t1x9gknd 5963 1 Platelets platelet NNS cord-010119-t1x9gknd 5963 2 ( ( -LRB- cord-010119-t1x9gknd 5963 3 containing contain VBG cord-010119-t1x9gknd 5963 4 HPA-1aa HPA-1aa NNP cord-010119-t1x9gknd 5963 5 , , , cord-010119-t1x9gknd 5963 6 HPA-3ab HPA-3ab NNP cord-010119-t1x9gknd 5963 7 and and CC cord-010119-t1x9gknd 5963 8 HPA-5aa HPA-5aa NNP cord-010119-t1x9gknd 5963 9 ) ) -RRB- cord-010119-t1x9gknd 5963 10 were be VBD cord-010119-t1x9gknd 5963 11 collected collect VBN cord-010119-t1x9gknd 5963 12 and and CC cord-010119-t1x9gknd 5963 13 reacted react VBN cord-010119-t1x9gknd 5963 14 with with IN cord-010119-t1x9gknd 5963 15 anti anti NNP cord-010119-t1x9gknd 5963 16 - - NNP cord-010119-t1x9gknd 5963 17 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5963 18 , , , cord-010119-t1x9gknd 5963 19 anti anti NNP cord-010119-t1x9gknd 5963 20 - - NNP cord-010119-t1x9gknd 5963 21 HPA-3a hpa-3a JJ cord-010119-t1x9gknd 5963 22 , , , cord-010119-t1x9gknd 5963 23 anti anti JJ cord-010119-t1x9gknd 5963 24 - - JJ cord-010119-t1x9gknd 5963 25 HPA-5a hpa-5a JJ cord-010119-t1x9gknd 5963 26 and and CC cord-010119-t1x9gknd 5963 27 anti anti JJ cord-010119-t1x9gknd 5963 28 - - JJ cord-010119-t1x9gknd 5963 29 HPA-5b HPA-5b NNP cord-010119-t1x9gknd 5963 30 standard standard NN cord-010119-t1x9gknd 5963 31 sera sera NNP cord-010119-t1x9gknd 5963 32 respectively respectively RB cord-010119-t1x9gknd 5963 33 , , , cord-010119-t1x9gknd 5963 34 then then RB cord-010119-t1x9gknd 5963 35 the the DT cord-010119-t1x9gknd 5963 36 antigen antigen NN cord-010119-t1x9gknd 5963 37 - - HYPH cord-010119-t1x9gknd 5963 38 antibody antibody NN cord-010119-t1x9gknd 5963 39 reaction reaction NN cord-010119-t1x9gknd 5963 40 complexes complex NNS cord-010119-t1x9gknd 5963 41 were be VBD cord-010119-t1x9gknd 5963 42 lysed lyse VBN cord-010119-t1x9gknd 5963 43 and and CC cord-010119-t1x9gknd 5963 44 the the DT cord-010119-t1x9gknd 5963 45 lysates lysate NNS cord-010119-t1x9gknd 5963 46 were be VBD cord-010119-t1x9gknd 5963 47 incubated incubate VBN cord-010119-t1x9gknd 5963 48 with with IN cord-010119-t1x9gknd 5963 49 luminex luminex NN cord-010119-t1x9gknd 5963 50 beads bead NNS cord-010119-t1x9gknd 5963 51 to to TO cord-010119-t1x9gknd 5963 52 specifically specifically RB cord-010119-t1x9gknd 5963 53 capture capture VB cord-010119-t1x9gknd 5963 54 antigen antigen NN cord-010119-t1x9gknd 5963 55 - - HYPH cord-010119-t1x9gknd 5963 56 antibody antibody NN cord-010119-t1x9gknd 5963 57 complexes complex NNS cord-010119-t1x9gknd 5963 58 via via IN cord-010119-t1x9gknd 5963 59 the the DT cord-010119-t1x9gknd 5963 60 epitopes epitope NNS cord-010119-t1x9gknd 5963 61 on on IN cord-010119-t1x9gknd 5963 62 platelet platelet NN cord-010119-t1x9gknd 5963 63 glycoproteins glycoprotein NNS cord-010119-t1x9gknd 5963 64 . . . cord-010119-t1x9gknd 5964 1 The the DT cord-010119-t1x9gknd 5964 2 beads bead NNS cord-010119-t1x9gknd 5964 3 - - HYPH cord-010119-t1x9gknd 5964 4 antigen antigen NN cord-010119-t1x9gknd 5964 5 - - HYPH cord-010119-t1x9gknd 5964 6 antibody antibody NN cord-010119-t1x9gknd 5964 7 complexes complex NNS cord-010119-t1x9gknd 5964 8 were be VBD cord-010119-t1x9gknd 5964 9 then then RB cord-010119-t1x9gknd 5964 10 subjected subject VBN cord-010119-t1x9gknd 5964 11 to to TO cord-010119-t1x9gknd 5964 12 flow flow VB cord-010119-t1x9gknd 5964 13 cytometric cytometric NNP cord-010119-t1x9gknd 5964 14 analysis analysis NN cord-010119-t1x9gknd 5964 15 on on IN cord-010119-t1x9gknd 5964 16 a a DT cord-010119-t1x9gknd 5964 17 Luminex100 Luminex100 NNP cord-010119-t1x9gknd 5964 18 . . . cord-010119-t1x9gknd 5965 1 The the DT cord-010119-t1x9gknd 5965 2 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5965 3 serum serum NN cord-010119-t1x9gknd 5965 4 was be VBD cord-010119-t1x9gknd 5965 5 diluted dilute VBN cord-010119-t1x9gknd 5965 6 to to IN cord-010119-t1x9gknd 5965 7 10 10 CD cord-010119-t1x9gknd 5965 8 serial serial JJ cord-010119-t1x9gknd 5965 9 dilutions dilution NNS cord-010119-t1x9gknd 5965 10 ( ( -LRB- cord-010119-t1x9gknd 5965 11 from from IN cord-010119-t1x9gknd 5965 12 neat neat JJ cord-010119-t1x9gknd 5965 13 to to IN cord-010119-t1x9gknd 5965 14 1/502 1/502 CD cord-010119-t1x9gknd 5965 15 ) ) -RRB- cord-010119-t1x9gknd 5965 16 to to TO cord-010119-t1x9gknd 5965 17 test test VB cord-010119-t1x9gknd 5965 18 the the DT cord-010119-t1x9gknd 5965 19 sensitivities sensitivity NNS cord-010119-t1x9gknd 5965 20 of of IN cord-010119-t1x9gknd 5965 21 MAIPA MAIPA NNP cord-010119-t1x9gknd 5965 22 and and CC cord-010119-t1x9gknd 5965 23 Luminex Luminex NNP cord-010119-t1x9gknd 5965 24 beads bead NNS cord-010119-t1x9gknd 5965 25 assay assay NN cord-010119-t1x9gknd 5965 26 . . . cord-010119-t1x9gknd 5966 1 The the DT cord-010119-t1x9gknd 5966 2 two two CD cord-010119-t1x9gknd 5966 3 methods method NNS cord-010119-t1x9gknd 5966 4 were be VBD cord-010119-t1x9gknd 5966 5 then then RB cord-010119-t1x9gknd 5966 6 used use VBN cord-010119-t1x9gknd 5966 7 to to TO cord-010119-t1x9gknd 5966 8 test test VB cord-010119-t1x9gknd 5966 9 five five CD cord-010119-t1x9gknd 5966 10 blinded blinded JJ cord-010119-t1x9gknd 5966 11 samples sample NNS cord-010119-t1x9gknd 5966 12 which which WDT cord-010119-t1x9gknd 5966 13 were be VBD cord-010119-t1x9gknd 5966 14 collected collect VBN cord-010119-t1x9gknd 5966 15 from from IN cord-010119-t1x9gknd 5966 16 FMAIT FMAIT NNP cord-010119-t1x9gknd 5966 17 patients patient NNS cord-010119-t1x9gknd 5966 18 . . . cord-010119-t1x9gknd 5967 1 Results result NNS cord-010119-t1x9gknd 5967 2 / / SYM cord-010119-t1x9gknd 5967 3 Finding finding NN cord-010119-t1x9gknd 5967 4 : : : cord-010119-t1x9gknd 5968 1 Luminex Luminex NNP cord-010119-t1x9gknd 5968 2 bead bead NN cord-010119-t1x9gknd 5968 3 technology technology NN cord-010119-t1x9gknd 5968 4 showed show VBD cord-010119-t1x9gknd 5968 5 that that IN cord-010119-t1x9gknd 5968 6 the the DT cord-010119-t1x9gknd 5968 7 MFI MFI NNP cord-010119-t1x9gknd 5968 8 values value NNS cord-010119-t1x9gknd 5968 9 of of IN cord-010119-t1x9gknd 5968 10 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5968 11 , , , cord-010119-t1x9gknd 5968 12 HPA-3a HPA-3a NNP cord-010119-t1x9gknd 5968 13 , , , cord-010119-t1x9gknd 5968 14 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 5968 15 standard standard JJ cord-010119-t1x9gknd 5968 16 sera sera NNP cord-010119-t1x9gknd 5968 17 samples sample NNS cord-010119-t1x9gknd 5968 18 reacted react VBD cord-010119-t1x9gknd 5968 19 with with IN cord-010119-t1x9gknd 5968 20 the the DT cord-010119-t1x9gknd 5968 21 coupled coupled JJ cord-010119-t1x9gknd 5968 22 beads bead NNS cord-010119-t1x9gknd 5968 23 were be VBD cord-010119-t1x9gknd 5968 24 significantly significantly RB cord-010119-t1x9gknd 5968 25 higher high JJR cord-010119-t1x9gknd 5968 26 than than IN cord-010119-t1x9gknd 5968 27 the the DT cord-010119-t1x9gknd 5968 28 negative negative JJ cord-010119-t1x9gknd 5968 29 controls control NNS cord-010119-t1x9gknd 5968 30 ( ( -LRB- cord-010119-t1x9gknd 5968 31 .08 .08 CD cord-010119-t1x9gknd 5968 32 vs vs IN cord-010119-t1x9gknd 5968 33 37.05 37.05 CD cord-010119-t1x9gknd 5968 34 ) ) -RRB- cord-010119-t1x9gknd 5968 35 , , , cord-010119-t1x9gknd 5968 36 which which WDT cord-010119-t1x9gknd 5968 37 implied imply VBD cord-010119-t1x9gknd 5968 38 that that IN cord-010119-t1x9gknd 5968 39 the the DT cord-010119-t1x9gknd 5968 40 Luminex Luminex NNP cord-010119-t1x9gknd 5968 41 bead bead NN cord-010119-t1x9gknd 5968 42 technology technology NN cord-010119-t1x9gknd 5968 43 could could MD cord-010119-t1x9gknd 5968 44 specifically specifically RB cord-010119-t1x9gknd 5968 45 identify identify VB cord-010119-t1x9gknd 5968 46 negative negative JJ cord-010119-t1x9gknd 5968 47 and and CC cord-010119-t1x9gknd 5968 48 positive positive JJ cord-010119-t1x9gknd 5968 49 sera sera NNP cord-010119-t1x9gknd 5968 50 of of IN cord-010119-t1x9gknd 5968 51 anti anti NNP cord-010119-t1x9gknd 5968 52 - - NNP cord-010119-t1x9gknd 5968 53 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5968 54 , , , cord-010119-t1x9gknd 5968 55 anti anti NNP cord-010119-t1x9gknd 5968 56 - - NNP cord-010119-t1x9gknd 5968 57 HPA-3a hpa-3a JJ cord-010119-t1x9gknd 5968 58 , , , cord-010119-t1x9gknd 5968 59 anti anti JJ cord-010119-t1x9gknd 5968 60 - - NNP cord-010119-t1x9gknd 5968 61 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 5968 62 . . . cord-010119-t1x9gknd 5969 1 Furthermore furthermore RB cord-010119-t1x9gknd 5969 2 , , , cord-010119-t1x9gknd 5969 3 because because IN cord-010119-t1x9gknd 5969 4 the the DT cord-010119-t1x9gknd 5969 5 platelet platelet NN cord-010119-t1x9gknd 5969 6 was be VBD cord-010119-t1x9gknd 5969 7 HPA-5aa HPA-5aa NNP cord-010119-t1x9gknd 5969 8 , , , cord-010119-t1x9gknd 5969 9 the the DT cord-010119-t1x9gknd 5969 10 HPA-5b HPA-5b NNP cord-010119-t1x9gknd 5969 11 serum serum NN cord-010119-t1x9gknd 5969 12 did do VBD cord-010119-t1x9gknd 5969 13 not not RB cord-010119-t1x9gknd 5969 14 react react VB cord-010119-t1x9gknd 5969 15 with with IN cord-010119-t1x9gknd 5969 16 the the DT cord-010119-t1x9gknd 5969 17 coupled coupled JJ cord-010119-t1x9gknd 5969 18 beads bead NNS cord-010119-t1x9gknd 5969 19 with with IN cord-010119-t1x9gknd 5969 20 MFI MFI NNP cord-010119-t1x9gknd 5969 21 was be VBD cord-010119-t1x9gknd 5969 22 comparable comparable JJ cord-010119-t1x9gknd 5969 23 to to IN cord-010119-t1x9gknd 5969 24 negative negative JJ cord-010119-t1x9gknd 5969 25 control control NN cord-010119-t1x9gknd 5969 26 ( ( -LRB- cord-010119-t1x9gknd 5969 27 286.59 286.59 CD cord-010119-t1x9gknd 5969 28 vs vs IN cord-010119-t1x9gknd 5969 29 127.25 127.25 CD cord-010119-t1x9gknd 5969 30 ) ) -RRB- cord-010119-t1x9gknd 5969 31 . . . cord-010119-t1x9gknd 5970 1 The the DT cord-010119-t1x9gknd 5970 2 sera sera NNP cord-010119-t1x9gknd 5970 3 were be VBD cord-010119-t1x9gknd 5970 4 re re VBN cord-010119-t1x9gknd 5970 5 - - VBN cord-010119-t1x9gknd 5970 6 tested test VBN cord-010119-t1x9gknd 5970 7 by by IN cord-010119-t1x9gknd 5970 8 MAIPA MAIPA NNP cord-010119-t1x9gknd 5970 9 and and CC cord-010119-t1x9gknd 5970 10 the the DT cord-010119-t1x9gknd 5970 11 results result NNS cord-010119-t1x9gknd 5970 12 of of IN cord-010119-t1x9gknd 5970 13 which which WDT cord-010119-t1x9gknd 5970 14 were be VBD cord-010119-t1x9gknd 5970 15 comparable comparable JJ cord-010119-t1x9gknd 5970 16 to to IN cord-010119-t1x9gknd 5970 17 Luminex Luminex NNP cord-010119-t1x9gknd 5970 18 bead bead NN cord-010119-t1x9gknd 5970 19 technology technology NN cord-010119-t1x9gknd 5970 20 , , , cord-010119-t1x9gknd 5970 21 illustrating illustrate VBG cord-010119-t1x9gknd 5970 22 that that IN cord-010119-t1x9gknd 5970 23 detecting detect VBG cord-010119-t1x9gknd 5970 24 HPA HPA NNP cord-010119-t1x9gknd 5970 25 antibodies antibody NNS cord-010119-t1x9gknd 5970 26 by by IN cord-010119-t1x9gknd 5970 27 Luminex Luminex NNP cord-010119-t1x9gknd 5970 28 beads bead NNS cord-010119-t1x9gknd 5970 29 technology technology NN cord-010119-t1x9gknd 5970 30 was be VBD cord-010119-t1x9gknd 5970 31 successful successful JJ cord-010119-t1x9gknd 5970 32 . . . cord-010119-t1x9gknd 5971 1 The the DT cord-010119-t1x9gknd 5971 2 sensitivity sensitivity NN cord-010119-t1x9gknd 5971 3 of of IN cord-010119-t1x9gknd 5971 4 Luminex Luminex NNP cord-010119-t1x9gknd 5971 5 bead bead NN cord-010119-t1x9gknd 5971 6 assay assay NN cord-010119-t1x9gknd 5971 7 and and CC cord-010119-t1x9gknd 5971 8 MAIPA MAIPA NNP cord-010119-t1x9gknd 5971 9 to to TO cord-010119-t1x9gknd 5971 10 detect detect VB cord-010119-t1x9gknd 5971 11 anti anti NNP cord-010119-t1x9gknd 5971 12 - - NNP cord-010119-t1x9gknd 5971 13 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5971 14 was be VBD cord-010119-t1x9gknd 5971 15 1/128 1/128 JJ cord-010119-t1x9gknd 5971 16 ( ( -LRB- cord-010119-t1x9gknd 5971 17 0.78IU 0.78iu CD cord-010119-t1x9gknd 5971 18 / / SYM cord-010119-t1x9gknd 5971 19 ml ml NN cord-010119-t1x9gknd 5971 20 ) ) -RRB- cord-010119-t1x9gknd 5971 21 and and CC cord-010119-t1x9gknd 5971 22 1/64 1/64 IN cord-010119-t1x9gknd 5971 23 ( ( -LRB- cord-010119-t1x9gknd 5971 24 1.56IU 1.56iu CD cord-010119-t1x9gknd 5971 25 / / SYM cord-010119-t1x9gknd 5971 26 ml ml NN cord-010119-t1x9gknd 5971 27 ) ) -RRB- cord-010119-t1x9gknd 5971 28 , , , cord-010119-t1x9gknd 5971 29 respectively respectively RB cord-010119-t1x9gknd 5971 30 . . . cord-010119-t1x9gknd 5972 1 No no DT cord-010119-t1x9gknd 5972 2 cross cross NN cord-010119-t1x9gknd 5972 3 - - NN cord-010119-t1x9gknd 5972 4 reactivity reactivity NN cord-010119-t1x9gknd 5972 5 was be VBD cord-010119-t1x9gknd 5972 6 observed observe VBN cord-010119-t1x9gknd 5972 7 with with IN cord-010119-t1x9gknd 5972 8 the the DT cord-010119-t1x9gknd 5972 9 samples sample NNS cord-010119-t1x9gknd 5972 10 containing contain VBG cord-010119-t1x9gknd 5972 11 HLA HLA NNP cord-010119-t1x9gknd 5972 12 , , , cord-010119-t1x9gknd 5972 13 ABO ABO NNP cord-010119-t1x9gknd 5972 14 or or CC cord-010119-t1x9gknd 5972 15 other other JJ cord-010119-t1x9gknd 5972 16 platelet platelet NN cord-010119-t1x9gknd 5972 17 antibodies antibody NNS cord-010119-t1x9gknd 5972 18 . . . cord-010119-t1x9gknd 5973 1 All all DT cord-010119-t1x9gknd 5973 2 results result NNS cord-010119-t1x9gknd 5973 3 of of IN cord-010119-t1x9gknd 5973 4 five five CD cord-010119-t1x9gknd 5973 5 blinded blinded JJ cord-010119-t1x9gknd 5973 6 samples sample NNS cord-010119-t1x9gknd 5973 7 tested test VBN cord-010119-t1x9gknd 5973 8 by by IN cord-010119-t1x9gknd 5973 9 Luminex Luminex NNP cord-010119-t1x9gknd 5973 10 assay assay NN cord-010119-t1x9gknd 5973 11 showed show VBD cord-010119-t1x9gknd 5973 12 that that IN cord-010119-t1x9gknd 5973 13 four four CD cord-010119-t1x9gknd 5973 14 sera sera NNP cord-010119-t1x9gknd 5973 15 were be VBD cord-010119-t1x9gknd 5973 16 positive positive JJ cord-010119-t1x9gknd 5973 17 for for IN cord-010119-t1x9gknd 5973 18 GPIIb GPIIb NNS cord-010119-t1x9gknd 5973 19 / / SYM cord-010119-t1x9gknd 5973 20 IIIa iiia NN cord-010119-t1x9gknd 5973 21 antibodies antibody NNS cord-010119-t1x9gknd 5973 22 which which WDT cord-010119-t1x9gknd 5973 23 were be VBD cord-010119-t1x9gknd 5973 24 consistent consistent JJ cord-010119-t1x9gknd 5973 25 with with IN cord-010119-t1x9gknd 5973 26 MAIPA MAIPA NNP cord-010119-t1x9gknd 5973 27 results result NNS cord-010119-t1x9gknd 5973 28 . . . cord-010119-t1x9gknd 5974 1 Conclusion conclusion NN cord-010119-t1x9gknd 5974 2 : : : cord-010119-t1x9gknd 5975 1 The the DT cord-010119-t1x9gknd 5975 2 Luminex Luminex NNP cord-010119-t1x9gknd 5975 3 beads bead NNS cord-010119-t1x9gknd 5975 4 coupled couple VBN cord-010119-t1x9gknd 5975 5 with with IN cord-010119-t1x9gknd 5975 6 GPIIb GPIIb NNS cord-010119-t1x9gknd 5975 7 / / SYM cord-010119-t1x9gknd 5975 8 IIIa IIIa NNS cord-010119-t1x9gknd 5975 9 and and CC cord-010119-t1x9gknd 5975 10 GPIa GPIa NNPS cord-010119-t1x9gknd 5975 11 / / SYM cord-010119-t1x9gknd 5975 12 IIa IIa NNP cord-010119-t1x9gknd 5975 13 monoclonal monoclonal JJ cord-010119-t1x9gknd 5975 14 antibodies antibody NNS cord-010119-t1x9gknd 5975 15 could could MD cord-010119-t1x9gknd 5975 16 be be VB cord-010119-t1x9gknd 5975 17 successfully successfully RB cord-010119-t1x9gknd 5975 18 used use VBN cord-010119-t1x9gknd 5975 19 to to TO cord-010119-t1x9gknd 5975 20 detect detect VB cord-010119-t1x9gknd 5975 21 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 5975 22 , , , cord-010119-t1x9gknd 5975 23 HPA-3a HPA-3a NNP cord-010119-t1x9gknd 5975 24 and and CC cord-010119-t1x9gknd 5975 25 HPA-5a HPA-5a NNP cord-010119-t1x9gknd 5975 26 antibodies antibody NNS cord-010119-t1x9gknd 5975 27 via via IN cord-010119-t1x9gknd 5975 28 the the DT cord-010119-t1x9gknd 5975 29 epitopes epitope NNS cord-010119-t1x9gknd 5975 30 on on IN cord-010119-t1x9gknd 5975 31 platelet platelet NN cord-010119-t1x9gknd 5975 32 glycoproteins glycoprotein NNS cord-010119-t1x9gknd 5975 33 . . . cord-010119-t1x9gknd 5976 1 The the DT cord-010119-t1x9gknd 5976 2 sensitivity sensitivity NN cord-010119-t1x9gknd 5976 3 of of IN cord-010119-t1x9gknd 5976 4 Luminex Luminex NNP cord-010119-t1x9gknd 5976 5 technology technology NN cord-010119-t1x9gknd 5976 6 was be VBD cord-010119-t1x9gknd 5976 7 higher high JJR cord-010119-t1x9gknd 5976 8 than than IN cord-010119-t1x9gknd 5976 9 MAIPA MAIPA NNP cord-010119-t1x9gknd 5976 10 technology technology NN cord-010119-t1x9gknd 5976 11 . . . cord-010119-t1x9gknd 5977 1 ( ( -LRB- cord-010119-t1x9gknd 5977 2 aHUS aHUS NNP cord-010119-t1x9gknd 5977 3 ) ) -RRB- cord-010119-t1x9gknd 5977 4 is be VBZ cord-010119-t1x9gknd 5977 5 a a DT cord-010119-t1x9gknd 5977 6 thrombotic thrombotic JJ cord-010119-t1x9gknd 5977 7 microangiopathy microangiopathy NN cord-010119-t1x9gknd 5977 8 ( ( -LRB- cord-010119-t1x9gknd 5977 9 TMA TMA NNP cord-010119-t1x9gknd 5977 10 ) ) -RRB- cord-010119-t1x9gknd 5977 11 characterized characterize VBN cord-010119-t1x9gknd 5977 12 by by IN cord-010119-t1x9gknd 5977 13 the the DT cord-010119-t1x9gknd 5977 14 triad triad NNP cord-010119-t1x9gknd 5977 15 of of IN cord-010119-t1x9gknd 5977 16 microangiopathic microangiopathic JJ cord-010119-t1x9gknd 5977 17 hemolytic hemolytic JJ cord-010119-t1x9gknd 5977 18 anemia anemia NN cord-010119-t1x9gknd 5977 19 , , , cord-010119-t1x9gknd 5977 20 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 5977 21 and and CC cord-010119-t1x9gknd 5977 22 renal renal JJ cord-010119-t1x9gknd 5977 23 failure failure NN cord-010119-t1x9gknd 5977 24 in in IN cord-010119-t1x9gknd 5977 25 the the DT cord-010119-t1x9gknd 5977 26 absence absence NN cord-010119-t1x9gknd 5977 27 of of IN cord-010119-t1x9gknd 5977 28 infectious infectious JJ cord-010119-t1x9gknd 5977 29 toxin toxin NN cord-010119-t1x9gknd 5977 30 . . . cord-010119-t1x9gknd 5978 1 The the DT cord-010119-t1x9gknd 5978 2 literature literature NN cord-010119-t1x9gknd 5978 3 suggests suggest VBZ cord-010119-t1x9gknd 5978 4 the the DT cord-010119-t1x9gknd 5978 5 presence presence NN cord-010119-t1x9gknd 5978 6 of of IN cord-010119-t1x9gknd 5978 7 pathogenic pathogenic JJ cord-010119-t1x9gknd 5978 8 mutations mutation NNS cord-010119-t1x9gknd 5978 9 in in IN cord-010119-t1x9gknd 5978 10 complement complement JJ cord-010119-t1x9gknd 5978 11 proteins protein NNS cord-010119-t1x9gknd 5978 12 in in IN cord-010119-t1x9gknd 5978 13 50 50 CD cord-010119-t1x9gknd 5978 14 % % NN cord-010119-t1x9gknd 5978 15 of of IN cord-010119-t1x9gknd 5978 16 cases case NNS cord-010119-t1x9gknd 5978 17 of of IN cord-010119-t1x9gknd 5978 18 aHUS ahus DT cord-010119-t1x9gknd 5978 19 . . . cord-010119-t1x9gknd 5979 1 There there EX cord-010119-t1x9gknd 5979 2 is be VBZ cord-010119-t1x9gknd 5979 3 a a DT cord-010119-t1x9gknd 5979 4 lack lack NN cord-010119-t1x9gknd 5979 5 of of IN cord-010119-t1x9gknd 5979 6 well well RB cord-010119-t1x9gknd 5979 7 - - HYPH cord-010119-t1x9gknd 5979 8 defined define VBN cord-010119-t1x9gknd 5979 9 recommendations recommendation NNS cord-010119-t1x9gknd 5979 10 regarding regard VBG cord-010119-t1x9gknd 5979 11 testing testing NN cord-010119-t1x9gknd 5979 12 for for IN cord-010119-t1x9gknd 5979 13 genetic genetic JJ cord-010119-t1x9gknd 5979 14 aHUS ahus NN cord-010119-t1x9gknd 5979 15 . . . cord-010119-t1x9gknd 5980 1 Complement complement JJ cord-010119-t1x9gknd 5980 2 pathway pathway NN cord-010119-t1x9gknd 5980 3 mutation mutation NN cord-010119-t1x9gknd 5980 4 analysis analysis NN cord-010119-t1x9gknd 5980 5 is be VBZ cord-010119-t1x9gknd 5980 6 an an DT cord-010119-t1x9gknd 5980 7 expensive expensive JJ cord-010119-t1x9gknd 5980 8 test test NN cord-010119-t1x9gknd 5980 9 so so RB cord-010119-t1x9gknd 5980 10 appropriate appropriate JJ cord-010119-t1x9gknd 5980 11 utilization utilization NN cord-010119-t1x9gknd 5980 12 is be VBZ cord-010119-t1x9gknd 5980 13 crucial crucial JJ cord-010119-t1x9gknd 5980 14 to to TO cord-010119-t1x9gknd 5980 15 prevent prevent VB cord-010119-t1x9gknd 5980 16 undue undue JJ cord-010119-t1x9gknd 5980 17 health health NN cord-010119-t1x9gknd 5980 18 care care NN cord-010119-t1x9gknd 5980 19 costs cost NNS cord-010119-t1x9gknd 5980 20 . . . cord-010119-t1x9gknd 5981 1 We -PRON- PRP cord-010119-t1x9gknd 5981 2 reviewed review VBD cord-010119-t1x9gknd 5981 3 the the DT cord-010119-t1x9gknd 5981 4 indications indication NNS cord-010119-t1x9gknd 5981 5 for for IN cord-010119-t1x9gknd 5981 6 genetic genetic JJ cord-010119-t1x9gknd 5981 7 testing testing NN cord-010119-t1x9gknd 5981 8 to to TO cord-010119-t1x9gknd 5981 9 understand understand VB cord-010119-t1x9gknd 5981 10 physician physician NN cord-010119-t1x9gknd 5981 11 ordering order VBG cord-010119-t1x9gknd 5981 12 practice practice NN cord-010119-t1x9gknd 5981 13 and and CC cord-010119-t1x9gknd 5981 14 determine determine VB cord-010119-t1x9gknd 5981 15 the the DT cord-010119-t1x9gknd 5981 16 frequency frequency NN cord-010119-t1x9gknd 5981 17 of of IN cord-010119-t1x9gknd 5981 18 pathogenic pathogenic JJ cord-010119-t1x9gknd 5981 19 mutations mutation NNS cord-010119-t1x9gknd 5981 20 in in IN cord-010119-t1x9gknd 5981 21 the the DT cord-010119-t1x9gknd 5981 22 population population NN cord-010119-t1x9gknd 5981 23 . . . cord-010119-t1x9gknd 5982 1 Study Study NNP cord-010119-t1x9gknd 5982 2 Design Design NNP cord-010119-t1x9gknd 5982 3 / / SYM cord-010119-t1x9gknd 5982 4 Method method NN cord-010119-t1x9gknd 5982 5 : : : cord-010119-t1x9gknd 5982 6 We -PRON- PRP cord-010119-t1x9gknd 5982 7 performed perform VBD cord-010119-t1x9gknd 5982 8 a a DT cord-010119-t1x9gknd 5982 9 retrospective retrospective JJ cord-010119-t1x9gknd 5982 10 review review NN cord-010119-t1x9gknd 5982 11 of of IN cord-010119-t1x9gknd 5982 12 all all DT cord-010119-t1x9gknd 5982 13 cases case NNS cord-010119-t1x9gknd 5982 14 referred refer VBN cord-010119-t1x9gknd 5982 15 for for IN cord-010119-t1x9gknd 5982 16 complement complement JJ cord-010119-t1x9gknd 5982 17 pathway pathway NN cord-010119-t1x9gknd 5982 18 mutation mutation NN cord-010119-t1x9gknd 5982 19 analysis analysis NN cord-010119-t1x9gknd 5982 20 to to IN cord-010119-t1x9gknd 5982 21 a a DT cord-010119-t1x9gknd 5982 22 national national JJ cord-010119-t1x9gknd 5982 23 reference reference NN cord-010119-t1x9gknd 5982 24 laboratory laboratory NN cord-010119-t1x9gknd 5982 25 from from IN cord-010119-t1x9gknd 5982 26 1 1 CD cord-010119-t1x9gknd 5982 27 January January NNP cord-010119-t1x9gknd 5982 28 2014 2014 CD cord-010119-t1x9gknd 5982 29 to to IN cord-010119-t1x9gknd 5982 30 31 31 CD cord-010119-t1x9gknd 5982 31 December December NNP cord-010119-t1x9gknd 5982 32 2016 2016 CD cord-010119-t1x9gknd 5982 33 . . . cord-010119-t1x9gknd 5983 1 Clinical clinical JJ cord-010119-t1x9gknd 5983 2 history history NN cord-010119-t1x9gknd 5983 3 was be VBD cord-010119-t1x9gknd 5983 4 solicited solicit VBN cord-010119-t1x9gknd 5983 5 by by IN cord-010119-t1x9gknd 5983 6 genetic genetic JJ cord-010119-t1x9gknd 5983 7 counselors counselor NNS cord-010119-t1x9gknd 5983 8 . . . cord-010119-t1x9gknd 5984 1 Cases case NNS cord-010119-t1x9gknd 5984 2 were be VBD cord-010119-t1x9gknd 5984 3 classified classify VBN cord-010119-t1x9gknd 5984 4 by by IN cord-010119-t1x9gknd 5984 5 the the DT cord-010119-t1x9gknd 5984 6 authors author NNS cord-010119-t1x9gknd 5984 7 as as IN cord-010119-t1x9gknd 5984 8 primary primary JJ cord-010119-t1x9gknd 5984 9 aHUS aHUS . cord-010119-t1x9gknd 5985 1 ( ( -LRB- cord-010119-t1x9gknd 5985 2 TMA TMA NNP cord-010119-t1x9gknd 5985 3 and and CC cord-010119-t1x9gknd 5985 4 renal renal JJ cord-010119-t1x9gknd 5985 5 failure failure NN cord-010119-t1x9gknd 5985 6 without without IN cord-010119-t1x9gknd 5985 7 identifiable identifiable JJ cord-010119-t1x9gknd 5985 8 cause cause NN cord-010119-t1x9gknd 5985 9 ) ) -RRB- cord-010119-t1x9gknd 5985 10 , , , cord-010119-t1x9gknd 5985 11 secondary secondary JJ cord-010119-t1x9gknd 5985 12 TMA TMA NNP cord-010119-t1x9gknd 5985 13 ( ( -LRB- cord-010119-t1x9gknd 5985 14 TMA TMA NNP cord-010119-t1x9gknd 5985 15 and and CC cord-010119-t1x9gknd 5985 16 renal renal JJ cord-010119-t1x9gknd 5985 17 failure failure NN cord-010119-t1x9gknd 5985 18 with with IN cord-010119-t1x9gknd 5985 19 identifiable identifiable JJ cord-010119-t1x9gknd 5985 20 cause cause NN cord-010119-t1x9gknd 5985 21 previously previously RB cord-010119-t1x9gknd 5985 22 associated associate VBN cord-010119-t1x9gknd 5985 23 with with IN cord-010119-t1x9gknd 5985 24 TMA TMA NNP cord-010119-t1x9gknd 5985 25 ) ) -RRB- cord-010119-t1x9gknd 5985 26 or or CC cord-010119-t1x9gknd 5985 27 non non JJ cord-010119-t1x9gknd 5985 28 - - JJ cord-010119-t1x9gknd 5985 29 TMA tma JJ cord-010119-t1x9gknd 5985 30 . . . cord-010119-t1x9gknd 5986 1 The the DT cord-010119-t1x9gknd 5986 2 test test NN cord-010119-t1x9gknd 5986 3 panel panel NN cord-010119-t1x9gknd 5986 4 identified identify VBD cord-010119-t1x9gknd 5986 5 variants variant NNS cord-010119-t1x9gknd 5986 6 in in IN cord-010119-t1x9gknd 5986 7 complement complement JJ cord-010119-t1x9gknd 5986 8 proteins protein NNS cord-010119-t1x9gknd 5987 1 ( ( -LRB- cord-010119-t1x9gknd 5987 2 CFH CFH NNP cord-010119-t1x9gknd 5987 3 , , , cord-010119-t1x9gknd 5987 4 CFI CFI NNP cord-010119-t1x9gknd 5987 5 , , , cord-010119-t1x9gknd 5987 6 MCP MCP NNP cord-010119-t1x9gknd 5987 7 , , , cord-010119-t1x9gknd 5987 8 Factor Factor NNP cord-010119-t1x9gknd 5987 9 B B NNP cord-010119-t1x9gknd 5987 10 , , , cord-010119-t1x9gknd 5987 11 C3 C3 NNP cord-010119-t1x9gknd 5987 12 , , , cord-010119-t1x9gknd 5987 13 C4BP C4BP NNP cord-010119-t1x9gknd 5987 14 , , , cord-010119-t1x9gknd 5987 15 THBD THBD NNP cord-010119-t1x9gknd 5987 16 , , , cord-010119-t1x9gknd 5987 17 DGKE DGKE NNP cord-010119-t1x9gknd 5987 18 , , , cord-010119-t1x9gknd 5987 19 CFHR3 cfhr3 NN cord-010119-t1x9gknd 5987 20 , , , cord-010119-t1x9gknd 5987 21 CFHR1 cfhr1 NN cord-010119-t1x9gknd 5987 22 , , , cord-010119-t1x9gknd 5987 23 CFHR4 CFHR4 NNS cord-010119-t1x9gknd 5987 24 and and CC cord-010119-t1x9gknd 5987 25 CFHR5 cfhr5 NN cord-010119-t1x9gknd 5987 26 ) ) -RRB- cord-010119-t1x9gknd 5987 27 that that WDT cord-010119-t1x9gknd 5987 28 were be VBD cord-010119-t1x9gknd 5987 29 classified classify VBN cord-010119-t1x9gknd 5987 30 as as IN cord-010119-t1x9gknd 5987 31 VUS VUS NNP cord-010119-t1x9gknd 5987 32 ( ( -LRB- cord-010119-t1x9gknd 5987 33 variances variance NNS cord-010119-t1x9gknd 5987 34 of of IN cord-010119-t1x9gknd 5987 35 uncertain uncertain JJ cord-010119-t1x9gknd 5987 36 significance significance NN cord-010119-t1x9gknd 5987 37 ) ) -RRB- cord-010119-t1x9gknd 5987 38 , , , cord-010119-t1x9gknd 5987 39 pathogenic pathogenic JJ cord-010119-t1x9gknd 5987 40 or or CC cord-010119-t1x9gknd 5987 41 benign benign JJ cord-010119-t1x9gknd 5987 42 by by IN cord-010119-t1x9gknd 5987 43 the the DT cord-010119-t1x9gknd 5987 44 American American NNP cord-010119-t1x9gknd 5987 45 College College NNP cord-010119-t1x9gknd 5987 46 of of IN cord-010119-t1x9gknd 5987 47 Medical Medical NNP cord-010119-t1x9gknd 5987 48 Genetics Genetics NNP cord-010119-t1x9gknd 5987 49 . . . cord-010119-t1x9gknd 5988 1 Chi Chi NNP cord-010119-t1x9gknd 5988 2 square square JJ cord-010119-t1x9gknd 5988 3 analysis analysis NN cord-010119-t1x9gknd 5988 4 / / SYM cord-010119-t1x9gknd 5988 5 Fishers Fishers NNPS cord-010119-t1x9gknd 5988 6 ' ' POS cord-010119-t1x9gknd 5988 7 exact exact JJ cord-010119-t1x9gknd 5988 8 test test NN cord-010119-t1x9gknd 5988 9 was be VBD cord-010119-t1x9gknd 5988 10 used use VBN cord-010119-t1x9gknd 5988 11 to to TO cord-010119-t1x9gknd 5988 12 determine determine VB cord-010119-t1x9gknd 5988 13 differences difference NNS cord-010119-t1x9gknd 5988 14 in in IN cord-010119-t1x9gknd 5988 15 proportion proportion NN cord-010119-t1x9gknd 5988 16 of of IN cord-010119-t1x9gknd 5988 17 patients patient NNS cord-010119-t1x9gknd 5988 18 with with IN cord-010119-t1x9gknd 5988 19 pathogenic pathogenic JJ cord-010119-t1x9gknd 5988 20 mutations mutation NNS cord-010119-t1x9gknd 5988 21 and and CC cord-010119-t1x9gknd 5988 22 primary primary JJ cord-010119-t1x9gknd 5988 23 aHUS ahus DT cord-010119-t1x9gknd 5988 24 versus versus IN cord-010119-t1x9gknd 5988 25 secondary secondary JJ cord-010119-t1x9gknd 5988 26 TMA TMA NNP cord-010119-t1x9gknd 5988 27 . . . cord-010119-t1x9gknd 5989 1 Independent independent JJ cord-010119-t1x9gknd 5989 2 sample sample NN cord-010119-t1x9gknd 5989 3 t t NN cord-010119-t1x9gknd 5989 4 - - HYPH cord-010119-t1x9gknd 5989 5 test test NN cord-010119-t1x9gknd 5989 6 was be VBD cord-010119-t1x9gknd 5989 7 used use VBN cord-010119-t1x9gknd 5989 8 to to TO cord-010119-t1x9gknd 5989 9 compare compare VB cord-010119-t1x9gknd 5989 10 differences difference NNS cord-010119-t1x9gknd 5989 11 in in IN cord-010119-t1x9gknd 5989 12 continuous continuous JJ cord-010119-t1x9gknd 5989 13 variables variable NNS cord-010119-t1x9gknd 5989 14 between between IN cord-010119-t1x9gknd 5989 15 primary primary JJ cord-010119-t1x9gknd 5989 16 aHUS ahus JJ cord-010119-t1x9gknd 5989 17 and and CC cord-010119-t1x9gknd 5989 18 secondary secondary JJ cord-010119-t1x9gknd 5989 19 TMA TMA NNP cord-010119-t1x9gknd 5989 20 . . . cord-010119-t1x9gknd 5990 1 Results result NNS cord-010119-t1x9gknd 5990 2 / / SYM cord-010119-t1x9gknd 5990 3 Finding finding NN cord-010119-t1x9gknd 5990 4 : : : cord-010119-t1x9gknd 5990 5 Of of IN cord-010119-t1x9gknd 5990 6 134 134 CD cord-010119-t1x9gknd 5990 7 patients patient NNS cord-010119-t1x9gknd 5990 8 tested test VBN cord-010119-t1x9gknd 5990 9 , , , cord-010119-t1x9gknd 5990 10 pathogenic pathogenic JJ cord-010119-t1x9gknd 5990 11 mutations mutation NNS cord-010119-t1x9gknd 5990 12 were be VBD cord-010119-t1x9gknd 5990 13 detected detect VBN cord-010119-t1x9gknd 5990 14 in in IN cord-010119-t1x9gknd 5990 15 13 13 CD cord-010119-t1x9gknd 5990 16 % % NN cord-010119-t1x9gknd 5990 17 ( ( -LRB- cord-010119-t1x9gknd 5990 18 18/134 18/134 CD cord-010119-t1x9gknd 5990 19 ) ) -RRB- cord-010119-t1x9gknd 5990 20 and and CC cord-010119-t1x9gknd 5990 21 VUS VUS NNP cord-010119-t1x9gknd 5990 22 in in IN cord-010119-t1x9gknd 5990 23 35 35 CD cord-010119-t1x9gknd 5990 24 % % NN cord-010119-t1x9gknd 5990 25 ( ( -LRB- cord-010119-t1x9gknd 5990 26 47/134 47/134 CD cord-010119-t1x9gknd 5990 27 ) ) -RRB- cord-010119-t1x9gknd 5990 28 . . . cord-010119-t1x9gknd 5991 1 20 20 CD cord-010119-t1x9gknd 5991 2 % % NN cord-010119-t1x9gknd 5991 3 ( ( -LRB- cord-010119-t1x9gknd 5991 4 27/134 27/134 CD cord-010119-t1x9gknd 5991 5 ) ) -RRB- cord-010119-t1x9gknd 5991 6 of of IN cord-010119-t1x9gknd 5991 7 patients patient NNS cord-010119-t1x9gknd 5991 8 did do VBD cord-010119-t1x9gknd 5991 9 not not RB cord-010119-t1x9gknd 5991 10 fulfill fulfill VB cord-010119-t1x9gknd 5991 11 criteria criterion NNS cord-010119-t1x9gknd 5991 12 for for IN cord-010119-t1x9gknd 5991 13 TMA TMA NNP cord-010119-t1x9gknd 5991 14 ; ; : cord-010119-t1x9gknd 5991 15 no no DT cord-010119-t1x9gknd 5991 16 pathogenic pathogenic JJ cord-010119-t1x9gknd 5991 17 mutations mutation NNS cord-010119-t1x9gknd 5991 18 were be VBD cord-010119-t1x9gknd 5991 19 found find VBN cord-010119-t1x9gknd 5991 20 in in IN cord-010119-t1x9gknd 5991 21 this this DT cord-010119-t1x9gknd 5991 22 group group NN cord-010119-t1x9gknd 5991 23 and and CC cord-010119-t1x9gknd 5991 24 9 9 CD cord-010119-t1x9gknd 5991 25 ( ( -LRB- cord-010119-t1x9gknd 5991 26 33 33 CD cord-010119-t1x9gknd 5991 27 % % NN cord-010119-t1x9gknd 5991 28 ) ) -RRB- cord-010119-t1x9gknd 5991 29 had have VBD cord-010119-t1x9gknd 5991 30 VUS VUS NNP cord-010119-t1x9gknd 5991 31 . . . cord-010119-t1x9gknd 5992 1 31 31 CD cord-010119-t1x9gknd 5992 2 % % NN cord-010119-t1x9gknd 5992 3 ( ( -LRB- cord-010119-t1x9gknd 5992 4 42/134 42/134 CD cord-010119-t1x9gknd 5992 5 ) ) -RRB- cord-010119-t1x9gknd 5992 6 of of IN cord-010119-t1x9gknd 5992 7 patients patient NNS cord-010119-t1x9gknd 5992 8 had have VBD cord-010119-t1x9gknd 5992 9 primary primary JJ cord-010119-t1x9gknd 5992 10 aHUS ahus NN cord-010119-t1x9gknd 5992 11 ; ; : cord-010119-t1x9gknd 5992 12 of of IN cord-010119-t1x9gknd 5992 13 these these DT cord-010119-t1x9gknd 5992 14 , , , cord-010119-t1x9gknd 5992 15 28 28 CD cord-010119-t1x9gknd 5992 16 % % NN cord-010119-t1x9gknd 5992 17 ( ( -LRB- cord-010119-t1x9gknd 5992 18 12/42 12/42 CD cord-010119-t1x9gknd 5992 19 ) ) -RRB- cord-010119-t1x9gknd 5992 20 had have VBD cord-010119-t1x9gknd 5992 21 pathogenic pathogenic JJ cord-010119-t1x9gknd 5992 22 mutations mutation NNS cord-010119-t1x9gknd 5992 23 and and CC cord-010119-t1x9gknd 5992 24 40 40 CD cord-010119-t1x9gknd 5992 25 % % NN cord-010119-t1x9gknd 5992 26 ( ( -LRB- cord-010119-t1x9gknd 5992 27 17/42 17/42 CD cord-010119-t1x9gknd 5992 28 ) ) -RRB- cord-010119-t1x9gknd 5992 29 had have VBD cord-010119-t1x9gknd 5992 30 VUS VUS NNP cord-010119-t1x9gknd 5992 31 . . . cord-010119-t1x9gknd 5993 1 48 48 CD cord-010119-t1x9gknd 5993 2 % % NN cord-010119-t1x9gknd 5993 3 ( ( -LRB- cord-010119-t1x9gknd 5993 4 65/134 65/134 CD cord-010119-t1x9gknd 5993 5 ) ) -RRB- cord-010119-t1x9gknd 5993 6 of of IN cord-010119-t1x9gknd 5993 7 patients patient NNS cord-010119-t1x9gknd 5993 8 had have VBD cord-010119-t1x9gknd 5993 9 secondary secondary JJ cord-010119-t1x9gknd 5993 10 TMA TMA NNP cord-010119-t1x9gknd 5993 11 ; ; : cord-010119-t1x9gknd 5993 12 of of IN cord-010119-t1x9gknd 5993 13 these these DT cord-010119-t1x9gknd 5993 14 , , , cord-010119-t1x9gknd 5993 15 9 9 CD cord-010119-t1x9gknd 5993 16 % % NN cord-010119-t1x9gknd 5993 17 ( ( -LRB- cord-010119-t1x9gknd 5993 18 6/65 6/65 CD cord-010119-t1x9gknd 5993 19 ) ) -RRB- cord-010119-t1x9gknd 5993 20 had have VBD cord-010119-t1x9gknd 5993 21 pathogenic pathogenic JJ cord-010119-t1x9gknd 5993 22 mutations mutation NNS cord-010119-t1x9gknd 5993 23 and and CC cord-010119-t1x9gknd 5993 24 32 32 CD cord-010119-t1x9gknd 5993 25 % % NN cord-010119-t1x9gknd 5993 26 ( ( -LRB- cord-010119-t1x9gknd 5993 27 21/65 21/65 CD cord-010119-t1x9gknd 5993 28 ) ) -RRB- cord-010119-t1x9gknd 5993 29 had have VBD cord-010119-t1x9gknd 5993 30 VUS VUS NNP cord-010119-t1x9gknd 5993 31 . . . cord-010119-t1x9gknd 5994 1 In in IN cord-010119-t1x9gknd 5994 2 patients patient NNS cord-010119-t1x9gknd 5994 3 with with IN cord-010119-t1x9gknd 5994 4 pathogenic pathogenic JJ cord-010119-t1x9gknd 5994 5 mutations mutation NNS cord-010119-t1x9gknd 5994 6 , , , cord-010119-t1x9gknd 5994 7 39 39 CD cord-010119-t1x9gknd 5994 8 % % NN cord-010119-t1x9gknd 5994 9 ( ( -LRB- cord-010119-t1x9gknd 5994 10 7/18 7/18 CD cord-010119-t1x9gknd 5994 11 ) ) -RRB- cord-010119-t1x9gknd 5994 12 were be VBD cord-010119-t1x9gknd 5994 13 children child NNS cord-010119-t1x9gknd 5994 14 , , , cord-010119-t1x9gknd 5994 15 22.5 22.5 CD cord-010119-t1x9gknd 5994 16 % % NN cord-010119-t1x9gknd 5994 17 ( ( -LRB- cord-010119-t1x9gknd 5994 18 4/18 4/18 CD cord-010119-t1x9gknd 5994 19 ) ) -RRB- cord-010119-t1x9gknd 5994 20 had have VBD cord-010119-t1x9gknd 5994 21 a a DT cord-010119-t1x9gknd 5994 22 positive positive JJ cord-010119-t1x9gknd 5994 23 family family NN cord-010119-t1x9gknd 5994 24 history history NN cord-010119-t1x9gknd 5994 25 of of IN cord-010119-t1x9gknd 5994 26 aHUS ahus DT cord-010119-t1x9gknd 5994 27 and and CC cord-010119-t1x9gknd 5994 28 28 28 CD cord-010119-t1x9gknd 5994 29 % % NN cord-010119-t1x9gknd 5994 30 ( ( -LRB- cord-010119-t1x9gknd 5994 31 5/18 5/18 CD cord-010119-t1x9gknd 5994 32 ) ) -RRB- cord-010119-t1x9gknd 5994 33 had have VBD cord-010119-t1x9gknd 5994 34 recurrent recurrent JJ cord-010119-t1x9gknd 5994 35 disease disease NN cord-010119-t1x9gknd 5994 36 . . . cord-010119-t1x9gknd 5995 1 Patients patient NNS cord-010119-t1x9gknd 5995 2 with with IN cord-010119-t1x9gknd 5995 3 primary primary JJ cord-010119-t1x9gknd 5995 4 aHUS aHUS NNP cord-010119-t1x9gknd 5995 5 had have VBD cord-010119-t1x9gknd 5995 6 a a DT cord-010119-t1x9gknd 5995 7 significantly significantly RB cord-010119-t1x9gknd 5995 8 lower low JJR cord-010119-t1x9gknd 5995 9 age age NN cord-010119-t1x9gknd 5995 10 at at IN cord-010119-t1x9gknd 5995 11 presentation presentation NN cord-010119-t1x9gknd 5995 12 ( ( -LRB- cord-010119-t1x9gknd 5995 13 22 22 CD cord-010119-t1x9gknd 5995 14 6 6 CD cord-010119-t1x9gknd 5995 15 18 18 CD cord-010119-t1x9gknd 5995 16 vs. vs. IN cord-010119-t1x9gknd 5995 17 33 33 CD cord-010119-t1x9gknd 5995 18 6 6 CD cord-010119-t1x9gknd 5995 19 20 20 CD cord-010119-t1x9gknd 5995 20 yrs yr NNS cord-010119-t1x9gknd 5995 21 ; ; : cord-010119-t1x9gknd 5995 22 p p NN cord-010119-t1x9gknd 5995 23 - - HYPH cord-010119-t1x9gknd 5995 24 value value NN cord-010119-t1x9gknd 5995 25 : : : cord-010119-t1x9gknd 5995 26 0.005 0.005 CD cord-010119-t1x9gknd 5995 27 ) ) -RRB- cord-010119-t1x9gknd 5995 28 and and CC cord-010119-t1x9gknd 5995 29 a a DT cord-010119-t1x9gknd 5995 30 higher high JJR cord-010119-t1x9gknd 5995 31 proportion proportion NN cord-010119-t1x9gknd 5995 32 of of IN cord-010119-t1x9gknd 5995 33 pathogenic pathogenic JJ cord-010119-t1x9gknd 5995 34 mutations mutation NNS cord-010119-t1x9gknd 5995 35 ( ( -LRB- cord-010119-t1x9gknd 5995 36 28 28 CD cord-010119-t1x9gknd 5995 37 % % NN cord-010119-t1x9gknd 5995 38 vs. vs. IN cord-010119-t1x9gknd 5995 39 9 9 CD cord-010119-t1x9gknd 5995 40 % % NN cord-010119-t1x9gknd 5995 41 p p NN cord-010119-t1x9gknd 5995 42 - - HYPH cord-010119-t1x9gknd 5995 43 value value NN cord-010119-t1x9gknd 5995 44 : : : cord-010119-t1x9gknd 5995 45 0.009 0.009 CD cord-010119-t1x9gknd 5995 46 ) ) -RRB- cord-010119-t1x9gknd 5995 47 compared compare VBN cord-010119-t1x9gknd 5995 48 to to IN cord-010119-t1x9gknd 5995 49 patients patient NNS cord-010119-t1x9gknd 5995 50 with with IN cord-010119-t1x9gknd 5995 51 secondary secondary JJ cord-010119-t1x9gknd 5995 52 TMA TMA NNP cord-010119-t1x9gknd 5995 53 . . . cord-010119-t1x9gknd 5996 1 Gender gender NN cord-010119-t1x9gknd 5996 2 distribution distribution NN cord-010119-t1x9gknd 5996 3 , , , cord-010119-t1x9gknd 5996 4 hemoglobin hemoglobin NN cord-010119-t1x9gknd 5996 5 nadir nadir NN cord-010119-t1x9gknd 5996 6 and and CC cord-010119-t1x9gknd 5996 7 serum serum NN cord-010119-t1x9gknd 5996 8 creatinine creatinine NN cord-010119-t1x9gknd 5996 9 levels level NNS cord-010119-t1x9gknd 5996 10 were be VBD cord-010119-t1x9gknd 5996 11 similar similar JJ cord-010119-t1x9gknd 5996 12 between between IN cord-010119-t1x9gknd 5996 13 the the DT cord-010119-t1x9gknd 5996 14 two two CD cord-010119-t1x9gknd 5996 15 groups group NNS cord-010119-t1x9gknd 5996 16 . . . cord-010119-t1x9gknd 5997 1 Conclusion conclusion NN cord-010119-t1x9gknd 5997 2 : : : cord-010119-t1x9gknd 5998 1 We -PRON- PRP cord-010119-t1x9gknd 5998 2 found find VBD cord-010119-t1x9gknd 5998 3 a a DT cord-010119-t1x9gknd 5998 4 lower low JJR cord-010119-t1x9gknd 5998 5 frequency frequency NN cord-010119-t1x9gknd 5998 6 of of IN cord-010119-t1x9gknd 5998 7 patients patient NNS cord-010119-t1x9gknd 5998 8 with with IN cord-010119-t1x9gknd 5998 9 pathogenic pathogenic JJ cord-010119-t1x9gknd 5998 10 mutations mutation NNS cord-010119-t1x9gknd 5998 11 compared compare VBN cord-010119-t1x9gknd 5998 12 to to IN cord-010119-t1x9gknd 5998 13 reported report VBN cord-010119-t1x9gknd 5998 14 literature literature NN cord-010119-t1x9gknd 5998 15 . . . cord-010119-t1x9gknd 5999 1 Our -PRON- PRP$ cord-010119-t1x9gknd 5999 2 data data NN cord-010119-t1x9gknd 5999 3 suggests suggest VBZ cord-010119-t1x9gknd 5999 4 that that IN cord-010119-t1x9gknd 5999 5 patients patient NNS cord-010119-t1x9gknd 5999 6 with with IN cord-010119-t1x9gknd 5999 7 secondary secondary JJ cord-010119-t1x9gknd 5999 8 TMA TMA NNP cord-010119-t1x9gknd 5999 9 should should MD cord-010119-t1x9gknd 5999 10 be be VB cord-010119-t1x9gknd 5999 11 carefully carefully RB cord-010119-t1x9gknd 5999 12 evaluated evaluate VBN cord-010119-t1x9gknd 5999 13 prior prior RB cord-010119-t1x9gknd 5999 14 to to IN cord-010119-t1x9gknd 5999 15 ordering order VBG cord-010119-t1x9gknd 5999 16 genetic genetic JJ cord-010119-t1x9gknd 5999 17 testing testing NN cord-010119-t1x9gknd 5999 18 and and CC cord-010119-t1x9gknd 5999 19 those those DT cord-010119-t1x9gknd 5999 20 without without IN cord-010119-t1x9gknd 5999 21 TMA TMA NNP cord-010119-t1x9gknd 5999 22 should should MD cord-010119-t1x9gknd 5999 23 not not RB cord-010119-t1x9gknd 5999 24 undergo undergo VB cord-010119-t1x9gknd 5999 25 this this DT cord-010119-t1x9gknd 5999 26 test test NN cord-010119-t1x9gknd 5999 27 . . . cord-010119-t1x9gknd 6000 1 Counting count VBG cord-010119-t1x9gknd 6000 2 of of IN cord-010119-t1x9gknd 6000 3 Platelets platelet NNS cord-010119-t1x9gknd 6000 4 in in IN cord-010119-t1x9gknd 6000 5 Platelet platelet NN cord-010119-t1x9gknd 6000 6 Concentrates concentrate VBZ cord-010119-t1x9gknd 6000 7 on on IN cord-010119-t1x9gknd 6000 8 Hematology Hematology NNP cord-010119-t1x9gknd 6000 9 Analyzers Analyzers NNPS cord-010119-t1x9gknd 6000 10 PentraXL80 pentraxl80 CD cord-010119-t1x9gknd 6000 11 and and CC cord-010119-t1x9gknd 6000 12 Sysmex Sysmex NNP cord-010119-t1x9gknd 6000 13 XN9000 XN9000 . cord-010119-t1x9gknd 6001 1 Compared compare VBN cord-010119-t1x9gknd 6001 2 with with IN cord-010119-t1x9gknd 6001 3 a a DT cord-010119-t1x9gknd 6001 4 Flow flow NN cord-010119-t1x9gknd 6001 5 Cytometric Cytometric NNP cord-010119-t1x9gknd 6001 6 Method Method NNP cord-010119-t1x9gknd 6001 7 Farshid Farshid NNP cord-010119-t1x9gknd 6001 8 Ezligini Ezligini NNP cord-010119-t1x9gknd 6001 9 1 1 CD cord-010119-t1x9gknd 6001 10 , , , cord-010119-t1x9gknd 6001 11 Kjersti Kjersti NNP cord-010119-t1x9gknd 6001 12 Roen Roen NNP cord-010119-t1x9gknd 6001 13 Eriksen Eriksen NNP cord-010119-t1x9gknd 6001 14 1 1 CD cord-010119-t1x9gknd 6001 15 , , , cord-010119-t1x9gknd 6001 16 Annette Annette NNP cord-010119-t1x9gknd 6001 17 Vetlesen Vetlesen NNP cord-010119-t1x9gknd 6001 18 1 1 CD cord-010119-t1x9gknd 6001 19 , , , cord-010119-t1x9gknd 6001 20 Thomas Thomas NNP cord-010119-t1x9gknd 6001 21 Larsen Larsen NNP cord-010119-t1x9gknd 6001 22 Titze Titze NNP cord-010119-t1x9gknd 6001 23 1 1 CD cord-010119-t1x9gknd 6001 24 and and CC cord-010119-t1x9gknd 6001 25 Geir Geir NNP cord-010119-t1x9gknd 6001 26 Hetland Hetland NNP cord-010119-t1x9gknd 6002 1 * * NFP cord-010119-t1x9gknd 6002 2 1,2 1,2 CD cord-010119-t1x9gknd 6002 3 . . . cord-010119-t1x9gknd 6003 1 1 1 LS cord-010119-t1x9gknd 6004 1 Oslo Oslo NNP cord-010119-t1x9gknd 6004 2 University University NNP cord-010119-t1x9gknd 6004 3 Hospital Hospital NNP cord-010119-t1x9gknd 6004 4 , , , cord-010119-t1x9gknd 6004 5 2 2 CD cord-010119-t1x9gknd 6004 6 University University NNP cord-010119-t1x9gknd 6004 7 of of IN cord-010119-t1x9gknd 6004 8 Oslo Oslo NNP cord-010119-t1x9gknd 6004 9 Background Background NNP cord-010119-t1x9gknd 6004 10 / / SYM cord-010119-t1x9gknd 6004 11 Case Case NNP cord-010119-t1x9gknd 6004 12 Studies Studies NNPS cord-010119-t1x9gknd 6004 13 : : : cord-010119-t1x9gknd 6005 1 Hematology hematology NN cord-010119-t1x9gknd 6005 2 analyzers analyzer NNS cord-010119-t1x9gknd 6005 3 are be VBP cord-010119-t1x9gknd 6005 4 made make VBN cord-010119-t1x9gknd 6005 5 for for IN cord-010119-t1x9gknd 6005 6 counting counting NN cord-010119-t1x9gknd 6005 7 of of IN cord-010119-t1x9gknd 6005 8 whole whole JJ cord-010119-t1x9gknd 6005 9 blood blood NN cord-010119-t1x9gknd 6005 10 samples sample NNS cord-010119-t1x9gknd 6005 11 but but CC cord-010119-t1x9gknd 6005 12 are be VBP cord-010119-t1x9gknd 6005 13 often often RB cord-010119-t1x9gknd 6005 14 used use VBN cord-010119-t1x9gknd 6005 15 for for IN cord-010119-t1x9gknd 6005 16 quality quality NN cord-010119-t1x9gknd 6005 17 control control NN cord-010119-t1x9gknd 6005 18 of of IN cord-010119-t1x9gknd 6005 19 blood blood NN cord-010119-t1x9gknd 6005 20 components component NNS cord-010119-t1x9gknd 6005 21 such such JJ cord-010119-t1x9gknd 6005 22 as as IN cord-010119-t1x9gknd 6005 23 platelet platelet NN cord-010119-t1x9gknd 6005 24 ( ( -LRB- cord-010119-t1x9gknd 6005 25 PLT PLT NNP cord-010119-t1x9gknd 6005 26 ) ) -RRB- cord-010119-t1x9gknd 6005 27 concentrates concentrate VBZ cord-010119-t1x9gknd 6005 28 ( ( -LRB- cord-010119-t1x9gknd 6005 29 PCs pc NNS cord-010119-t1x9gknd 6005 30 ) ) -RRB- cord-010119-t1x9gknd 6005 31 . . . cord-010119-t1x9gknd 6006 1 A a DT cord-010119-t1x9gknd 6006 2 flow flow NN cord-010119-t1x9gknd 6006 3 cytometric cytometric NN cord-010119-t1x9gknd 6006 4 method method NN cord-010119-t1x9gknd 6006 5 for for IN cord-010119-t1x9gknd 6006 6 counting counting NN cord-010119-t1x9gknd 6006 7 of of IN cord-010119-t1x9gknd 6006 8 PLT PLT NNP cord-010119-t1x9gknd 6006 9 in in IN cord-010119-t1x9gknd 6006 10 PCs pc NNS cord-010119-t1x9gknd 6006 11 has have VBZ cord-010119-t1x9gknd 6006 12 been be VBN cord-010119-t1x9gknd 6006 13 developed develop VBN cord-010119-t1x9gknd 6006 14 as as IN cord-010119-t1x9gknd 6006 15 validation validation NN cord-010119-t1x9gknd 6006 16 tool tool NN cord-010119-t1x9gknd 6006 17 ( ( -LRB- cord-010119-t1x9gknd 6006 18 van van NNP cord-010119-t1x9gknd 6006 19 der der NNP cord-010119-t1x9gknd 6006 20 Meer Meer NNP cord-010119-t1x9gknd 6006 21 et et NNP cord-010119-t1x9gknd 6006 22 al al NNP cord-010119-t1x9gknd 6006 23 , , , cord-010119-t1x9gknd 6006 24 Transfusion Transfusion NNP cord-010119-t1x9gknd 6006 25 2012 2012 CD cord-010119-t1x9gknd 6006 26 ) ) -RRB- cord-010119-t1x9gknd 6006 27 . . . cord-010119-t1x9gknd 6007 1 Therefore therefore RB cord-010119-t1x9gknd 6007 2 , , , cord-010119-t1x9gknd 6007 3 it -PRON- PRP cord-010119-t1x9gknd 6007 4 is be VBZ cord-010119-t1x9gknd 6007 5 pertinent pertinent JJ cord-010119-t1x9gknd 6007 6 to to TO cord-010119-t1x9gknd 6007 7 evaluate evaluate VB cord-010119-t1x9gknd 6007 8 PLT PLT NNP cord-010119-t1x9gknd 6007 9 counting counting NN cord-010119-t1x9gknd 6007 10 in in IN cord-010119-t1x9gknd 6007 11 BCs BCs NNP cord-010119-t1x9gknd 6007 12 on on IN cord-010119-t1x9gknd 6007 13 hematology hematology NN cord-010119-t1x9gknd 6007 14 analyzers analyzer NNS cord-010119-t1x9gknd 6007 15 with with IN cord-010119-t1x9gknd 6007 16 this this DT cord-010119-t1x9gknd 6007 17 validation validation NN cord-010119-t1x9gknd 6007 18 method method NN cord-010119-t1x9gknd 6007 19 in in IN cord-010119-t1x9gknd 6007 20 a a DT cord-010119-t1x9gknd 6007 21 flow flow NN cord-010119-t1x9gknd 6007 22 cytometer cytometer NN cord-010119-t1x9gknd 6007 23 . . . cord-010119-t1x9gknd 6008 1 Study Study NNP cord-010119-t1x9gknd 6008 2 Design Design NNP cord-010119-t1x9gknd 6008 3 / / SYM cord-010119-t1x9gknd 6008 4 Methods method NNS cord-010119-t1x9gknd 6008 5 : : : cord-010119-t1x9gknd 6009 1 Samples sample NNS cord-010119-t1x9gknd 6009 2 from from IN cord-010119-t1x9gknd 6009 3 ten ten CD cord-010119-t1x9gknd 6009 4 apheresis apheresis NN cord-010119-t1x9gknd 6009 5 PCs pc NNS cord-010119-t1x9gknd 6009 6 and and CC cord-010119-t1x9gknd 6009 7 33 33 CD cord-010119-t1x9gknd 6009 8 buffy buffy NNP cord-010119-t1x9gknd 6009 9 coat coat NN cord-010119-t1x9gknd 6009 10 - - HYPH cord-010119-t1x9gknd 6009 11 derived derive VBN cord-010119-t1x9gknd 6009 12 PCs pc NNS cord-010119-t1x9gknd 6009 13 were be VBD cord-010119-t1x9gknd 6009 14 subjected subject VBN cord-010119-t1x9gknd 6009 15 to to IN cord-010119-t1x9gknd 6009 16 PLT PLT NNP cord-010119-t1x9gknd 6009 17 counting count VBG cord-010119-t1x9gknd 6009 18 on on IN cord-010119-t1x9gknd 6009 19 hematology hematology NN cord-010119-t1x9gknd 6009 20 analyzers analyzer NNS cord-010119-t1x9gknd 6009 21 PentraXL80 PentraXL80 NNP cord-010119-t1x9gknd 6009 22 ( ( -LRB- cord-010119-t1x9gknd 6009 23 Horiba Horiba NNP cord-010119-t1x9gknd 6009 24 ABX ABX NNP cord-010119-t1x9gknd 6009 25 , , , cord-010119-t1x9gknd 6009 26 Montpelier Montpelier NNP cord-010119-t1x9gknd 6009 27 , , , cord-010119-t1x9gknd 6009 28 France France NNP cord-010119-t1x9gknd 6009 29 ) ) -RRB- cord-010119-t1x9gknd 6009 30 and and CC cord-010119-t1x9gknd 6009 31 XN9000 XN9000 . cord-010119-t1x9gknd 6009 32 Sysmex Sysmex NNP cord-010119-t1x9gknd 6009 33 TOA TOA NNP cord-010119-t1x9gknd 6009 34 ( ( -LRB- cord-010119-t1x9gknd 6009 35 Kobe Kobe NNP cord-010119-t1x9gknd 6009 36 , , , cord-010119-t1x9gknd 6009 37 Japan Japan NNP cord-010119-t1x9gknd 6009 38 ) ) -RRB- cord-010119-t1x9gknd 6009 39 ( ( -LRB- cord-010119-t1x9gknd 6009 40 both both DT cord-010119-t1x9gknd 6009 41 impedance impedance NN cord-010119-t1x9gknd 6009 42 score score NN cord-010119-t1x9gknd 6009 43 ) ) -RRB- cord-010119-t1x9gknd 6009 44 , , , cord-010119-t1x9gknd 6009 45 and and CC cord-010119-t1x9gknd 6009 46 additionally additionally RB cord-010119-t1x9gknd 6009 47 , , , cord-010119-t1x9gknd 6009 48 diluted dilute VBN cord-010119-t1x9gknd 6009 49 and and CC cord-010119-t1x9gknd 6009 50 stained stain VBN cord-010119-t1x9gknd 6009 51 with with IN cord-010119-t1x9gknd 6009 52 anti anti JJ cord-010119-t1x9gknd 6009 53 - - JJ cord-010119-t1x9gknd 6009 54 CD41a cd41a JJ cord-010119-t1x9gknd 6009 55 FITC fitc NN cord-010119-t1x9gknd 6009 56 in in IN cord-010119-t1x9gknd 6009 57 TrueCount TrueCount NNP cord-010119-t1x9gknd 6009 58 tubes tube NNS cord-010119-t1x9gknd 6009 59 ( ( -LRB- cord-010119-t1x9gknd 6009 60 BD BD NNP cord-010119-t1x9gknd 6009 61 Biosciences)(internal Biosciences)(internal NNP cord-010119-t1x9gknd 6009 62 bead bead NN cord-010119-t1x9gknd 6009 63 standard standard NN cord-010119-t1x9gknd 6009 64 ) ) -RRB- cord-010119-t1x9gknd 6009 65 for for IN cord-010119-t1x9gknd 6009 66 measuring measure VBG cord-010119-t1x9gknd 6009 67 in in IN cord-010119-t1x9gknd 6009 68 a a DT cord-010119-t1x9gknd 6009 69 Gallios Gallios NNP cord-010119-t1x9gknd 6009 70 flow flow NN cord-010119-t1x9gknd 6009 71 cytometer cytometer NN cord-010119-t1x9gknd 6009 72 ( ( -LRB- cord-010119-t1x9gknd 6009 73 Beckman Beckman NNP cord-010119-t1x9gknd 6009 74 Coulter Coulter NNP cord-010119-t1x9gknd 6009 75 , , , cord-010119-t1x9gknd 6009 76 Indianapolis Indianapolis NNP cord-010119-t1x9gknd 6009 77 IN IN NNP cord-010119-t1x9gknd 6009 78 , , , cord-010119-t1x9gknd 6009 79 USA USA NNP cord-010119-t1x9gknd 6009 80 ) ) -RRB- cord-010119-t1x9gknd 6009 81 . . . cord-010119-t1x9gknd 6010 1 Results result NNS cord-010119-t1x9gknd 6010 2 were be VBD cord-010119-t1x9gknd 6010 3 analyzed analyze VBN cord-010119-t1x9gknd 6010 4 by by IN cord-010119-t1x9gknd 6010 5 Paired Paired NNP cord-010119-t1x9gknd 6010 6 Samples Samples NNPS cord-010119-t1x9gknd 6010 7 Test Test NNP cord-010119-t1x9gknd 6010 8 and and CC cord-010119-t1x9gknd 6010 9 shown show VBN cord-010119-t1x9gknd 6010 10 in in IN cord-010119-t1x9gknd 6010 11 Bland Bland NNP cord-010119-t1x9gknd 6010 12 - - HYPH cord-010119-t1x9gknd 6010 13 Altmann Altmann NNP cord-010119-t1x9gknd 6010 14 plots plot NNS cord-010119-t1x9gknd 6010 15 . . . cord-010119-t1x9gknd 6011 1 Results/ Results/ . cord-010119-t1x9gknd 6012 1 Findings finding NNS cord-010119-t1x9gknd 6012 2 : : : cord-010119-t1x9gknd 6013 1 Mean mean JJ cord-010119-t1x9gknd 6013 2 PLT PLT NNP cord-010119-t1x9gknd 6013 3 values value VBZ cord-010119-t1x9gknd 6013 4 x10 x10 CD cord-010119-t1x9gknd 6013 5 9 9 CD cord-010119-t1x9gknd 6013 6 /L /l NN cord-010119-t1x9gknd 6013 7 6 6 CD cord-010119-t1x9gknd 6013 8 SD sd NN cord-010119-t1x9gknd 6013 9 were be VBD cord-010119-t1x9gknd 6013 10 819 819 CD cord-010119-t1x9gknd 6013 11 6118 6118 CD cord-010119-t1x9gknd 6013 12 , , , cord-010119-t1x9gknd 6013 13 ( ( -LRB- cord-010119-t1x9gknd 6014 1 < < XX cord-010119-t1x9gknd 6014 2 ) ) -RRB- cord-010119-t1x9gknd 6014 3 1106 1106 CD cord-010119-t1x9gknd 6014 4 6137 6137 CD cord-010119-t1x9gknd 6014 5 , , , cord-010119-t1x9gknd 6014 6 ( ( -LRB- cord-010119-t1x9gknd 6014 7 < < XX cord-010119-t1x9gknd 6014 8 ) ) -RRB- cord-010119-t1x9gknd 6014 9 and and CC cord-010119-t1x9gknd 6014 10 1195 1195 CD cord-010119-t1x9gknd 6014 11 6176 6176 CD cord-010119-t1x9gknd 6014 12 for for IN cord-010119-t1x9gknd 6014 13 counting count VBG cord-010119-t1x9gknd 6014 14 by by IN cord-010119-t1x9gknd 6014 15 Sysmex Sysmex NNP cord-010119-t1x9gknd 6014 16 TOA TOA NNP cord-010119-t1x9gknd 6014 17 , , , cord-010119-t1x9gknd 6014 18 PentraXL80 PentraXL80 NNP cord-010119-t1x9gknd 6014 19 , , , cord-010119-t1x9gknd 6014 20 and and CC cord-010119-t1x9gknd 6014 21 the the DT cord-010119-t1x9gknd 6014 22 Gallios Gallios NNP cord-010119-t1x9gknd 6014 23 flow flow NN cord-010119-t1x9gknd 6014 24 cytometer cytometer NN cord-010119-t1x9gknd 6014 25 , , , cord-010119-t1x9gknd 6014 26 respectively respectively RB cord-010119-t1x9gknd 6014 27 . . . cord-010119-t1x9gknd 6015 1 Sysmex Sysmex NNP cord-010119-t1x9gknd 6015 2 count count NN cord-010119-t1x9gknd 6015 3 was be VBD cord-010119-t1x9gknd 6015 4 the the DT cord-010119-t1x9gknd 6015 5 very very RB cord-010119-t1x9gknd 6015 6 lowest low JJS cord-010119-t1x9gknd 6015 7 129A 129a CD cord-010119-t1x9gknd 6015 8 TRANSFUSION transfusion NN cord-010119-t1x9gknd 6015 9 2017 2017 CD cord-010119-t1x9gknd 6015 10 Vol Vol NNP cord-010119-t1x9gknd 6015 11 . . . cord-010119-t1x9gknd 6016 1 57 57 CD cord-010119-t1x9gknd 6016 2 Supplement supplement NN cord-010119-t1x9gknd 6016 3 S3 S3 NNP cord-010119-t1x9gknd 6016 4 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 6016 5 ( ( -LRB- cord-010119-t1x9gknd 6016 6 31.4 31.4 CD cord-010119-t1x9gknd 6016 7 % % NN cord-010119-t1x9gknd 6016 8 less less JJR cord-010119-t1x9gknd 6016 9 than than IN cord-010119-t1x9gknd 6016 10 for for IN cord-010119-t1x9gknd 6016 11 flow flow NN cord-010119-t1x9gknd 6016 12 cytometry cytometry NN cord-010119-t1x9gknd 6016 13 ) ) -RRB- cord-010119-t1x9gknd 6016 14 , , , cord-010119-t1x9gknd 6016 15 but but CC cord-010119-t1x9gknd 6016 16 all all DT cord-010119-t1x9gknd 6016 17 PLT PLT NNP cord-010119-t1x9gknd 6016 18 counts count NNS cord-010119-t1x9gknd 6016 19 were be VBD cord-010119-t1x9gknd 6016 20 significantly significantly RB cord-010119-t1x9gknd 6016 21 different different JJ cord-010119-t1x9gknd 6016 22 ( ( -LRB- cord-010119-t1x9gknd 6016 23 p<0.001 p<0.001 JJ cord-010119-t1x9gknd 6016 24 ) ) -RRB- cord-010119-t1x9gknd 6016 25 , , , cord-010119-t1x9gknd 6016 26 although although IN cord-010119-t1x9gknd 6016 27 least least JJS cord-010119-t1x9gknd 6016 28 so so RB cord-010119-t1x9gknd 6016 29 ( ( -LRB- cord-010119-t1x9gknd 6016 30 7.4 7.4 CD cord-010119-t1x9gknd 6016 31 % % NN cord-010119-t1x9gknd 6016 32 ) ) -RRB- cord-010119-t1x9gknd 6016 33 between between IN cord-010119-t1x9gknd 6016 34 Pentra Pentra NNP cord-010119-t1x9gknd 6016 35 and and CC cord-010119-t1x9gknd 6016 36 flow flow NN cord-010119-t1x9gknd 6016 37 cytometry cytometry NN cord-010119-t1x9gknd 6016 38 . . . cord-010119-t1x9gknd 6017 1 Conclusion conclusion NN cord-010119-t1x9gknd 6017 2 : : : cord-010119-t1x9gknd 6018 1 As as IN cord-010119-t1x9gknd 6018 2 validated validate VBN cord-010119-t1x9gknd 6018 3 by by IN cord-010119-t1x9gknd 6018 4 the the DT cord-010119-t1x9gknd 6018 5 flow flow NN cord-010119-t1x9gknd 6018 6 cytometric cytometric NN cord-010119-t1x9gknd 6018 7 method method NN cord-010119-t1x9gknd 6018 8 , , , cord-010119-t1x9gknd 6018 9 PentraXL80 PentraXL80 NNP cord-010119-t1x9gknd 6018 10 seems seem VBZ cord-010119-t1x9gknd 6018 11 suitable suitable JJ cord-010119-t1x9gknd 6018 12 for for IN cord-010119-t1x9gknd 6018 13 routine routine JJ cord-010119-t1x9gknd 6018 14 quality quality NN cord-010119-t1x9gknd 6018 15 control control NN cord-010119-t1x9gknd 6018 16 of of IN cord-010119-t1x9gknd 6018 17 PCs pc NNS cord-010119-t1x9gknd 6018 18 both both DT cord-010119-t1x9gknd 6018 19 because because IN cord-010119-t1x9gknd 6018 20 of of IN cord-010119-t1x9gknd 6018 21 the the DT cord-010119-t1x9gknd 6018 22 small small JJ cord-010119-t1x9gknd 6018 23 difference difference NN cord-010119-t1x9gknd 6018 24 and and CC cord-010119-t1x9gknd 6018 25 lower low JJR cord-010119-t1x9gknd 6018 26 counts count NNS cord-010119-t1x9gknd 6018 27 compared compare VBN cord-010119-t1x9gknd 6018 28 with with IN cord-010119-t1x9gknd 6018 29 flow flow NN cord-010119-t1x9gknd 6018 30 cytometric cytometric NN cord-010119-t1x9gknd 6018 31 method method NN cord-010119-t1x9gknd 6018 32 , , , cord-010119-t1x9gknd 6018 33 which which WDT cord-010119-t1x9gknd 6018 34 is be VBZ cord-010119-t1x9gknd 6018 35 too too RB cord-010119-t1x9gknd 6018 36 cumbersome cumbersome JJ cord-010119-t1x9gknd 6018 37 in in IN cord-010119-t1x9gknd 6018 38 a a DT cord-010119-t1x9gknd 6018 39 routine routine JJ cord-010119-t1x9gknd 6018 40 setting setting NN cord-010119-t1x9gknd 6018 41 . . . cord-010119-t1x9gknd 6019 1 The the DT cord-010119-t1x9gknd 6019 2 much much RB cord-010119-t1x9gknd 6019 3 lower low JJR cord-010119-t1x9gknd 6019 4 PLT PLT NNP cord-010119-t1x9gknd 6019 5 count count NN cord-010119-t1x9gknd 6019 6 on on IN cord-010119-t1x9gknd 6019 7 Sysmex Sysmex NNP cord-010119-t1x9gknd 6019 8 may may MD cord-010119-t1x9gknd 6019 9 reflect reflect VB cord-010119-t1x9gknd 6019 10 its -PRON- PRP$ cord-010119-t1x9gknd 6019 11 optimization optimization NN cord-010119-t1x9gknd 6019 12 for for IN cord-010119-t1x9gknd 6019 13 PLT PLT NNP cord-010119-t1x9gknd 6019 14 counting count VBG cord-010119-t1x9gknd 6019 15 in in IN cord-010119-t1x9gknd 6019 16 whole whole JJ cord-010119-t1x9gknd 6019 17 blood blood NN cord-010119-t1x9gknd 6019 18 rather rather RB cord-010119-t1x9gknd 6019 19 than than IN cord-010119-t1x9gknd 6019 20 in in IN cord-010119-t1x9gknd 6019 21 PCs pc NNS cord-010119-t1x9gknd 6019 22 . . . cord-010119-t1x9gknd 6020 1 Fast fast RB cord-010119-t1x9gknd 6020 2 , , , cord-010119-t1x9gknd 6020 3 Precise Precise NNP cord-010119-t1x9gknd 6020 4 & & CC cord-010119-t1x9gknd 6020 5 Easy Easy NNP cord-010119-t1x9gknd 6021 1 HPA HPA NNP cord-010119-t1x9gknd 6021 2 Typing type VBG cord-010119-t1x9gknd 6021 3 with with IN cord-010119-t1x9gknd 6021 4 Real real JJ cord-010119-t1x9gknd 6021 5 - - HYPH cord-010119-t1x9gknd 6021 6 Time time NN cord-010119-t1x9gknd 6021 7 PCR PCR NNP cord-010119-t1x9gknd 6021 8 Jonathan Jonathan NNP cord-010119-t1x9gknd 6021 9 Downing Downing NNP cord-010119-t1x9gknd 6021 10 1 1 CD cord-010119-t1x9gknd 6021 11 , , , cord-010119-t1x9gknd 6021 12 Arishma Arishma NNP cord-010119-t1x9gknd 6021 13 Lata Lata NNP cord-010119-t1x9gknd 6021 14 1 1 CD cord-010119-t1x9gknd 6021 15 , , , cord-010119-t1x9gknd 6021 16 Roland Roland NNP cord-010119-t1x9gknd 6021 17 Russnak Russnak NNP cord-010119-t1x9gknd 6021 18 2 2 CD cord-010119-t1x9gknd 6021 19 , , , cord-010119-t1x9gknd 6021 20 Zachary Zachary NNP cord-010119-t1x9gknd 6021 21 Antovich Antovich NNP cord-010119-t1x9gknd 6021 22 2 2 CD cord-010119-t1x9gknd 6021 23 , , , cord-010119-t1x9gknd 6021 24 Heather Heather NNP cord-010119-t1x9gknd 6021 25 Dunckley Dunckley NNP cord-010119-t1x9gknd 6021 26 1 1 CD cord-010119-t1x9gknd 6021 27 and and CC cord-010119-t1x9gknd 6021 28 Thierry Thierry NNP cord-010119-t1x9gknd 6021 29 Viard Viard NNP cord-010119-t1x9gknd 6021 30 * * NFP cord-010119-t1x9gknd 6021 31 2 2 CD cord-010119-t1x9gknd 6021 32 . . . cord-010119-t1x9gknd 6021 33 1 1 CD cord-010119-t1x9gknd 6021 34 New New NNP cord-010119-t1x9gknd 6021 35 Zealand Zealand NNP cord-010119-t1x9gknd 6021 36 Blood Blood NNP cord-010119-t1x9gknd 6021 37 Service Service NNP cord-010119-t1x9gknd 6021 38 , , , cord-010119-t1x9gknd 6021 39 2 2 CD cord-010119-t1x9gknd 6021 40 Linkage Linkage NNP cord-010119-t1x9gknd 6021 41 Biosciences Biosciences NNPS cord-010119-t1x9gknd 6021 42 Background Background NNP cord-010119-t1x9gknd 6021 43 / / SYM cord-010119-t1x9gknd 6021 44 Case Case NNP cord-010119-t1x9gknd 6021 45 Studies Studies NNPS cord-010119-t1x9gknd 6021 46 : : : cord-010119-t1x9gknd 6022 1 The the DT cord-010119-t1x9gknd 6022 2 interaction interaction NN cord-010119-t1x9gknd 6022 3 of of IN cord-010119-t1x9gknd 6022 4 membrane membrane NN cord-010119-t1x9gknd 6022 5 - - HYPH cord-010119-t1x9gknd 6022 6 bound bind VBN cord-010119-t1x9gknd 6022 7 plateletspecific plateletspecific NNP cord-010119-t1x9gknd 6022 8 glycoproteins glycoprotein NNS cord-010119-t1x9gknd 6022 9 with with IN cord-010119-t1x9gknd 6022 10 the the DT cord-010119-t1x9gknd 6022 11 extracellular extracellular JJ cord-010119-t1x9gknd 6022 12 matrix matrix NN cord-010119-t1x9gknd 6022 13 plays play VBZ cord-010119-t1x9gknd 6022 14 a a DT cord-010119-t1x9gknd 6022 15 significant significant JJ cord-010119-t1x9gknd 6022 16 role role NN cord-010119-t1x9gknd 6022 17 in in IN cord-010119-t1x9gknd 6022 18 hemostasis hemostasis NN cord-010119-t1x9gknd 6022 19 . . . cord-010119-t1x9gknd 6023 1 Human Human NNP cord-010119-t1x9gknd 6023 2 Platelet platelet NN cord-010119-t1x9gknd 6023 3 Antigens Antigens NNP cord-010119-t1x9gknd 6023 4 ( ( -LRB- cord-010119-t1x9gknd 6023 5 HPA HPA NNP cord-010119-t1x9gknd 6023 6 ) ) -RRB- cord-010119-t1x9gknd 6023 7 found find VBD cord-010119-t1x9gknd 6023 8 within within IN cord-010119-t1x9gknd 6023 9 these these DT cord-010119-t1x9gknd 6023 10 glycoproteins glycoprotein NNS cord-010119-t1x9gknd 6023 11 can can MD cord-010119-t1x9gknd 6023 12 stimulate stimulate VB cord-010119-t1x9gknd 6023 13 production production NN cord-010119-t1x9gknd 6023 14 of of IN cord-010119-t1x9gknd 6023 15 antibodies antibody NNS cord-010119-t1x9gknd 6023 16 in in IN cord-010119-t1x9gknd 6023 17 recipients recipient NNS cord-010119-t1x9gknd 6023 18 of of IN cord-010119-t1x9gknd 6023 19 transfused transfused JJ cord-010119-t1x9gknd 6023 20 platelets platelet NNS cord-010119-t1x9gknd 6023 21 or or CC cord-010119-t1x9gknd 6023 22 in in IN cord-010119-t1x9gknd 6023 23 fetus fetus NN cord-010119-t1x9gknd 6023 24 of of IN cord-010119-t1x9gknd 6023 25 mothers mother NNS cord-010119-t1x9gknd 6023 26 with with IN cord-010119-t1x9gknd 6023 27 incompatible incompatible JJ cord-010119-t1x9gknd 6023 28 HPA hpa NN cord-010119-t1x9gknd 6023 29 . . . cord-010119-t1x9gknd 6024 1 Thus thus RB cord-010119-t1x9gknd 6024 2 , , , cord-010119-t1x9gknd 6024 3 platelet platelet NN cord-010119-t1x9gknd 6024 4 incompatibility incompatibility NN cord-010119-t1x9gknd 6024 5 is be VBZ cord-010119-t1x9gknd 6024 6 associated associate VBN cord-010119-t1x9gknd 6024 7 with with IN cord-010119-t1x9gknd 6024 8 various various JJ cord-010119-t1x9gknd 6024 9 forms form NNS cord-010119-t1x9gknd 6024 10 of of IN cord-010119-t1x9gknd 6024 11 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 6024 12 , , , cord-010119-t1x9gknd 6024 13 posttransfusion posttransfusion NN cord-010119-t1x9gknd 6024 14 purpura purpura NN cord-010119-t1x9gknd 6024 15 and and CC cord-010119-t1x9gknd 6024 16 other other JJ cord-010119-t1x9gknd 6024 17 blood blood NN cord-010119-t1x9gknd 6024 18 disorders disorder NNS cord-010119-t1x9gknd 6024 19 . . . cord-010119-t1x9gknd 6025 1 The the DT cord-010119-t1x9gknd 6025 2 New New NNP cord-010119-t1x9gknd 6025 3 Zealand Zealand NNP cord-010119-t1x9gknd 6025 4 Blood Blood NNP cord-010119-t1x9gknd 6025 5 Service Service NNP cord-010119-t1x9gknd 6025 6 performs perform VBZ cord-010119-t1x9gknd 6025 7 HPA HPA NNP cord-010119-t1x9gknd 6025 8 typing typing NN cord-010119-t1x9gknd 6025 9 on on IN cord-010119-t1x9gknd 6025 10 a a DT cord-010119-t1x9gknd 6025 11 pool pool NN cord-010119-t1x9gknd 6025 12 of of IN cord-010119-t1x9gknd 6025 13 platelet platelet NN cord-010119-t1x9gknd 6025 14 donors donor NNS cord-010119-t1x9gknd 6025 15 to to TO cord-010119-t1x9gknd 6025 16 provide provide VB cord-010119-t1x9gknd 6025 17 compatible compatible JJ cord-010119-t1x9gknd 6025 18 transfusions transfusion NNS cord-010119-t1x9gknd 6025 19 where where WRB cord-010119-t1x9gknd 6025 20 the the DT cord-010119-t1x9gknd 6025 21 need need NN cord-010119-t1x9gknd 6025 22 arises arise VBZ cord-010119-t1x9gknd 6025 23 . . . cord-010119-t1x9gknd 6026 1 The the DT cord-010119-t1x9gknd 6026 2 molecular molecular JJ cord-010119-t1x9gknd 6026 3 basis basis NN cord-010119-t1x9gknd 6026 4 of of IN cord-010119-t1x9gknd 6026 5 most most JJS cord-010119-t1x9gknd 6026 6 HPAs hpas NN cord-010119-t1x9gknd 6026 7 has have VBZ cord-010119-t1x9gknd 6026 8 been be VBN cord-010119-t1x9gknd 6026 9 characterized characterize VBN cord-010119-t1x9gknd 6026 10 as as RB cord-010119-t1x9gknd 6026 11 generally generally RB cord-010119-t1x9gknd 6026 12 caused cause VBN cord-010119-t1x9gknd 6026 13 by by IN cord-010119-t1x9gknd 6026 14 a a DT cord-010119-t1x9gknd 6026 15 single single JJ cord-010119-t1x9gknd 6026 16 - - HYPH cord-010119-t1x9gknd 6026 17 nucleotide nucleotide JJ cord-010119-t1x9gknd 6026 18 polymorphism polymorphism NN cord-010119-t1x9gknd 6026 19 ( ( -LRB- cord-010119-t1x9gknd 6026 20 SNP SNP NNP cord-010119-t1x9gknd 6026 21 ) ) -RRB- cord-010119-t1x9gknd 6026 22 . . . cord-010119-t1x9gknd 6027 1 HPA HPA NNP cord-010119-t1x9gknd 6027 2 typing typing NN cord-010119-t1x9gknd 6027 3 has have VBZ cord-010119-t1x9gknd 6027 4 typically typically RB cord-010119-t1x9gknd 6027 5 been be VBN cord-010119-t1x9gknd 6027 6 performed perform VBN cord-010119-t1x9gknd 6027 7 using use VBG cord-010119-t1x9gknd 6027 8 PCR PCR NNP cord-010119-t1x9gknd 6027 9 - - HYPH cord-010119-t1x9gknd 6027 10 SSP SSP NNP cord-010119-t1x9gknd 6027 11 , , , cord-010119-t1x9gknd 6027 12 a a DT cord-010119-t1x9gknd 6027 13 method method NN cord-010119-t1x9gknd 6027 14 that that WDT cord-010119-t1x9gknd 6027 15 utilizes utilize VBZ cord-010119-t1x9gknd 6027 16 time time NN cord-010119-t1x9gknd 6027 17 - - HYPH cord-010119-t1x9gknd 6027 18 consuming consume VBG cord-010119-t1x9gknd 6027 19 post post NN cord-010119-t1x9gknd 6027 20 PCR PCR NNP cord-010119-t1x9gknd 6027 21 analysis analysis NN cord-010119-t1x9gknd 6027 22 steps step NNS cord-010119-t1x9gknd 6027 23 . . . cord-010119-t1x9gknd 6028 1 The the DT cord-010119-t1x9gknd 6028 2 aim aim NN cord-010119-t1x9gknd 6028 3 of of IN cord-010119-t1x9gknd 6028 4 this this DT cord-010119-t1x9gknd 6028 5 study study NN cord-010119-t1x9gknd 6028 6 was be VBD cord-010119-t1x9gknd 6028 7 to to TO cord-010119-t1x9gknd 6028 8 evaluate evaluate VB cord-010119-t1x9gknd 6028 9 the the DT cord-010119-t1x9gknd 6028 10 use use NN cord-010119-t1x9gknd 6028 11 of of IN cord-010119-t1x9gknd 6028 12 real real JJ cord-010119-t1x9gknd 6028 13 - - HYPH cord-010119-t1x9gknd 6028 14 time time NN cord-010119-t1x9gknd 6028 15 PCR pcr NN cord-010119-t1x9gknd 6028 16 - - HYPH cord-010119-t1x9gknd 6028 17 based base VBN cord-010119-t1x9gknd 6028 18 techniques technique NNS cord-010119-t1x9gknd 6028 19 in in IN cord-010119-t1x9gknd 6028 20 a a DT cord-010119-t1x9gknd 6028 21 transfusion transfusion NN cord-010119-t1x9gknd 6028 22 laboratory laboratory NN cord-010119-t1x9gknd 6028 23 setting setting NN cord-010119-t1x9gknd 6028 24 . . . cord-010119-t1x9gknd 6029 1 Study Study NNP cord-010119-t1x9gknd 6029 2 Design Design NNP cord-010119-t1x9gknd 6029 3 / / SYM cord-010119-t1x9gknd 6029 4 Method method NN cord-010119-t1x9gknd 6029 5 : : : cord-010119-t1x9gknd 6029 6 We -PRON- PRP cord-010119-t1x9gknd 6029 7 evaluated evaluate VBD cord-010119-t1x9gknd 6029 8 a a DT cord-010119-t1x9gknd 6029 9 commercially commercially RB cord-010119-t1x9gknd 6029 10 available available JJ cord-010119-t1x9gknd 6029 11 solution solution NN cord-010119-t1x9gknd 6029 12 which which WDT cord-010119-t1x9gknd 6029 13 consists consist VBZ cord-010119-t1x9gknd 6029 14 of of IN cord-010119-t1x9gknd 6029 15 24 24 CD cord-010119-t1x9gknd 6029 16 reactions reaction NNS cord-010119-t1x9gknd 6029 17 that that WDT cord-010119-t1x9gknd 6029 18 identify identify VBP cord-010119-t1x9gknd 6029 19 both both DT cord-010119-t1x9gknd 6029 20 variants variant NNS cord-010119-t1x9gknd 6029 21 of of IN cord-010119-t1x9gknd 6029 22 12 12 CD cord-010119-t1x9gknd 6029 23 relevant relevant JJ cord-010119-t1x9gknd 6029 24 SNPs snp NNS cord-010119-t1x9gknd 6029 25 located locate VBN cord-010119-t1x9gknd 6029 26 within within IN cord-010119-t1x9gknd 6029 27 HPA HPA NNP cord-010119-t1x9gknd 6029 28 genes gene NNS cord-010119-t1x9gknd 6029 29 ( ( -LRB- cord-010119-t1x9gknd 6029 30 HPA-1 HPA-1 NNP cord-010119-t1x9gknd 6029 31 through through IN cord-010119-t1x9gknd 6029 32 HPA-11 hpa-11 CD cord-010119-t1x9gknd 6029 33 , , , cord-010119-t1x9gknd 6029 34 and and CC cord-010119-t1x9gknd 6029 35 HPA HPA NNP cord-010119-t1x9gknd 6029 36 15 15 CD cord-010119-t1x9gknd 6029 37 ) ) -RRB- cord-010119-t1x9gknd 6029 38 . . . cord-010119-t1x9gknd 6030 1 Genomic genomic JJ cord-010119-t1x9gknd 6030 2 DNA dna NN cord-010119-t1x9gknd 6030 3 purified purify VBN cord-010119-t1x9gknd 6030 4 from from IN cord-010119-t1x9gknd 6030 5 48 48 CD cord-010119-t1x9gknd 6030 6 blood blood NN cord-010119-t1x9gknd 6030 7 samples sample NNS cord-010119-t1x9gknd 6030 8 , , , cord-010119-t1x9gknd 6030 9 previously previously RB cord-010119-t1x9gknd 6030 10 genotyped genotype VBN cord-010119-t1x9gknd 6030 11 for for IN cord-010119-t1x9gknd 6030 12 HPA-1,-2,-3,-4,-5 HPA-1,-2,-3,-4,-5 NNP cord-010119-t1x9gknd 6030 13 and and CC cord-010119-t1x9gknd 6030 14 -15 -15 VBN cord-010119-t1x9gknd 6030 15 by by IN cord-010119-t1x9gknd 6030 16 our -PRON- PRP$ cord-010119-t1x9gknd 6030 17 in in IN cord-010119-t1x9gknd 6031 1 house house NNP cord-010119-t1x9gknd 6031 2 PCR PCR NNP cord-010119-t1x9gknd 6031 3 - - HYPH cord-010119-t1x9gknd 6031 4 SSP SSP NNP cord-010119-t1x9gknd 6031 5 method method NN cord-010119-t1x9gknd 6031 6 were be VBD cord-010119-t1x9gknd 6031 7 used use VBN cord-010119-t1x9gknd 6031 8 in in IN cord-010119-t1x9gknd 6031 9 this this DT cord-010119-t1x9gknd 6031 10 study study NN cord-010119-t1x9gknd 6031 11 as as IN cord-010119-t1x9gknd 6031 12 validation validation NN cord-010119-t1x9gknd 6031 13 samples sample NNS cord-010119-t1x9gknd 6031 14 . . . cord-010119-t1x9gknd 6032 1 Results/ Results/ . cord-010119-t1x9gknd 6033 1 Finding finding NN cord-010119-t1x9gknd 6033 2 : : : cord-010119-t1x9gknd 6034 1 Results result NNS cord-010119-t1x9gknd 6034 2 of of IN cord-010119-t1x9gknd 6034 3 the the DT cord-010119-t1x9gknd 6034 4 validation validation NN cord-010119-t1x9gknd 6034 5 samples sample NNS cord-010119-t1x9gknd 6034 6 were be VBD cord-010119-t1x9gknd 6034 7 100 100 CD cord-010119-t1x9gknd 6034 8 % % NN cord-010119-t1x9gknd 6034 9 concordant concordant JJ cord-010119-t1x9gknd 6034 10 with with IN cord-010119-t1x9gknd 6034 11 typing type VBG cord-010119-t1x9gknd 6034 12 obtained obtain VBN cord-010119-t1x9gknd 6034 13 by by IN cord-010119-t1x9gknd 6034 14 PCR PCR NNP cord-010119-t1x9gknd 6034 15 - - HYPH cord-010119-t1x9gknd 6034 16 SSP SSP NNP cord-010119-t1x9gknd 6034 17 . . . cord-010119-t1x9gknd 6035 1 The the DT cord-010119-t1x9gknd 6035 2 Real Real NNP cord-010119-t1x9gknd 6035 3 - - HYPH cord-010119-t1x9gknd 6035 4 Time time NN cord-010119-t1x9gknd 6035 5 PCR PCR NNP cord-010119-t1x9gknd 6035 6 approach approach NN cord-010119-t1x9gknd 6035 7 overcomes overcome VBZ cord-010119-t1x9gknd 6035 8 the the DT cord-010119-t1x9gknd 6035 9 major major JJ cord-010119-t1x9gknd 6035 10 challenges challenge NNS cord-010119-t1x9gknd 6035 11 of of IN cord-010119-t1x9gknd 6035 12 HPA HPA NNP cord-010119-t1x9gknd 6035 13 molecular molecular JJ cord-010119-t1x9gknd 6035 14 typing typing NN cord-010119-t1x9gknd 6035 15 by by IN cord-010119-t1x9gknd 6035 16 providing provide VBG cord-010119-t1x9gknd 6035 17 an an DT cord-010119-t1x9gknd 6035 18 automated automate VBN cord-010119-t1x9gknd 6035 19 solution solution NN cord-010119-t1x9gknd 6035 20 resulting result VBG cord-010119-t1x9gknd 6035 21 in in IN cord-010119-t1x9gknd 6035 22 increased increase VBN cord-010119-t1x9gknd 6035 23 laboratory laboratory NN cord-010119-t1x9gknd 6035 24 productivity productivity NN cord-010119-t1x9gknd 6035 25 and and CC cord-010119-t1x9gknd 6035 26 decreased decrease VBD cord-010119-t1x9gknd 6035 27 turn turn NN cord-010119-t1x9gknd 6035 28 - - HYPH cord-010119-t1x9gknd 6035 29 around around RP cord-010119-t1x9gknd 6035 30 time time NN cord-010119-t1x9gknd 6035 31 . . . cord-010119-t1x9gknd 6036 1 The the DT cord-010119-t1x9gknd 6036 2 analysis analysis NN cord-010119-t1x9gknd 6036 3 is be VBZ cord-010119-t1x9gknd 6036 4 facilitated facilitate VBN cord-010119-t1x9gknd 6036 5 by by IN cord-010119-t1x9gknd 6036 6 a a DT cord-010119-t1x9gknd 6036 7 software software NN cord-010119-t1x9gknd 6036 8 which which WDT cord-010119-t1x9gknd 6036 9 generates generate VBZ cord-010119-t1x9gknd 6036 10 the the DT cord-010119-t1x9gknd 6036 11 results result NNS cord-010119-t1x9gknd 6036 12 . . . cord-010119-t1x9gknd 6037 1 With with IN cord-010119-t1x9gknd 6037 2 less less JJR cord-010119-t1x9gknd 6037 3 than than IN cord-010119-t1x9gknd 6037 4 10 10 CD cord-010119-t1x9gknd 6037 5 minutes minute NNS cord-010119-t1x9gknd 6037 6 of of IN cord-010119-t1x9gknd 6037 7 hands hand NNS cord-010119-t1x9gknd 6037 8 - - HYPH cord-010119-t1x9gknd 6037 9 on on RP cord-010119-t1x9gknd 6037 10 set set NN cord-010119-t1x9gknd 6037 11 - - HYPH cord-010119-t1x9gknd 6037 12 up up NN cord-010119-t1x9gknd 6037 13 and and CC cord-010119-t1x9gknd 6037 14 no no DT cord-010119-t1x9gknd 6037 15 further further JJ cord-010119-t1x9gknd 6037 16 operator operator NN cord-010119-t1x9gknd 6037 17 intervention intervention NN cord-010119-t1x9gknd 6037 18 with with IN cord-010119-t1x9gknd 6037 19 the the DT cord-010119-t1x9gknd 6037 20 reagents reagent NNS cord-010119-t1x9gknd 6037 21 , , , cord-010119-t1x9gknd 6037 22 complete complete JJ cord-010119-t1x9gknd 6037 23 molecular molecular JJ cord-010119-t1x9gknd 6037 24 genotyping genotyping NN cord-010119-t1x9gknd 6037 25 results result NNS cord-010119-t1x9gknd 6037 26 are be VBP cord-010119-t1x9gknd 6037 27 provided provide VBN cord-010119-t1x9gknd 6037 28 in in IN cord-010119-t1x9gknd 6037 29 approximately approximately RB cord-010119-t1x9gknd 6037 30 90 90 CD cord-010119-t1x9gknd 6037 31 minutes minute NNS cord-010119-t1x9gknd 6037 32 . . . cord-010119-t1x9gknd 6038 1 Further further RB cord-010119-t1x9gknd 6038 2 , , , cord-010119-t1x9gknd 6038 3 since since IN cord-010119-t1x9gknd 6038 4 amplified amplify VBN cord-010119-t1x9gknd 6038 5 products product NNS cord-010119-t1x9gknd 6038 6 are be VBP cord-010119-t1x9gknd 6038 7 never never RB cord-010119-t1x9gknd 6038 8 handled handle VBN cord-010119-t1x9gknd 6038 9 , , , cord-010119-t1x9gknd 6038 10 the the DT cord-010119-t1x9gknd 6038 11 risk risk NN cord-010119-t1x9gknd 6038 12 of of IN cord-010119-t1x9gknd 6038 13 laboratory laboratory NN cord-010119-t1x9gknd 6038 14 contamination contamination NN cord-010119-t1x9gknd 6038 15 is be VBZ cord-010119-t1x9gknd 6038 16 significantly significantly RB cord-010119-t1x9gknd 6038 17 reduced reduce VBN cord-010119-t1x9gknd 6038 18 . . . cord-010119-t1x9gknd 6039 1 The the DT cord-010119-t1x9gknd 6039 2 Real Real NNP cord-010119-t1x9gknd 6039 3 - - HYPH cord-010119-t1x9gknd 6039 4 Time time NN cord-010119-t1x9gknd 6039 5 PCR PCR NNP cord-010119-t1x9gknd 6039 6 approach approach NN cord-010119-t1x9gknd 6039 7 with with IN cord-010119-t1x9gknd 6039 8 automated automate VBN cord-010119-t1x9gknd 6039 9 analysis analysis NN cord-010119-t1x9gknd 6039 10 was be VBD cord-010119-t1x9gknd 6039 11 implemented implement VBN cord-010119-t1x9gknd 6039 12 by by IN cord-010119-t1x9gknd 6039 13 the the DT cord-010119-t1x9gknd 6039 14 New New NNP cord-010119-t1x9gknd 6039 15 Zealand Zealand NNP cord-010119-t1x9gknd 6039 16 Blood Blood NNP cord-010119-t1x9gknd 6039 17 Service Service NNP cord-010119-t1x9gknd 6039 18 Tissue tissue NN cord-010119-t1x9gknd 6039 19 Typing type VBG cord-010119-t1x9gknd 6039 20 laboratory laboratory NN cord-010119-t1x9gknd 6039 21 in in IN cord-010119-t1x9gknd 6039 22 late late JJ cord-010119-t1x9gknd 6039 23 2016 2016 CD cord-010119-t1x9gknd 6039 24 and and CC cord-010119-t1x9gknd 6039 25 to to IN cord-010119-t1x9gknd 6039 26 date date NN cord-010119-t1x9gknd 6039 27 has have VBZ cord-010119-t1x9gknd 6039 28 tested test VBN cord-010119-t1x9gknd 6039 29 749 749 CD cord-010119-t1x9gknd 6039 30 DNA dna NN cord-010119-t1x9gknd 6039 31 samples sample NNS cord-010119-t1x9gknd 6039 32 from from IN cord-010119-t1x9gknd 6039 33 400 400 CD cord-010119-t1x9gknd 6039 34 blood blood NN cord-010119-t1x9gknd 6039 35 donors donor NNS cord-010119-t1x9gknd 6039 36 ( ( -LRB- cord-010119-t1x9gknd 6039 37 349 349 CD cord-010119-t1x9gknd 6039 38 donors donor NNS cord-010119-t1x9gknd 6039 39 were be VBD cord-010119-t1x9gknd 6039 40 tested test VBN cord-010119-t1x9gknd 6039 41 in in IN cord-010119-t1x9gknd 6039 42 duplicate duplicate NN cord-010119-t1x9gknd 6039 43 ) ) -RRB- cord-010119-t1x9gknd 6039 44 . . . cord-010119-t1x9gknd 6040 1 Concordance concordance NN cord-010119-t1x9gknd 6040 2 between between IN cord-010119-t1x9gknd 6040 3 the the DT cord-010119-t1x9gknd 6040 4 sample sample NN cord-010119-t1x9gknd 6040 5 replicates replicate NNS cord-010119-t1x9gknd 6040 6 was be VBD cord-010119-t1x9gknd 6040 7 100 100 CD cord-010119-t1x9gknd 6040 8 % % NN cord-010119-t1x9gknd 6040 9 . . . cord-010119-t1x9gknd 6041 1 There there EX cord-010119-t1x9gknd 6041 2 were be VBD cord-010119-t1x9gknd 6041 3 24 24 CD cord-010119-t1x9gknd 6041 4 occasions occasion NNS cord-010119-t1x9gknd 6041 5 where where WRB cord-010119-t1x9gknd 6041 6 the the DT cord-010119-t1x9gknd 6041 7 assay assay NN cord-010119-t1x9gknd 6041 8 had have VBD cord-010119-t1x9gknd 6041 9 to to TO cord-010119-t1x9gknd 6041 10 be be VB cord-010119-t1x9gknd 6041 11 repeated repeat VBN cord-010119-t1x9gknd 6041 12 , , , cord-010119-t1x9gknd 6041 13 giving give VBG cord-010119-t1x9gknd 6041 14 a a DT cord-010119-t1x9gknd 6041 15 repeat repeat NN cord-010119-t1x9gknd 6041 16 rate rate NN cord-010119-t1x9gknd 6041 17 of of IN cord-010119-t1x9gknd 6041 18 3.2 3.2 CD cord-010119-t1x9gknd 6041 19 % % NN cord-010119-t1x9gknd 6041 20 . . . cord-010119-t1x9gknd 6042 1 Occasionally occasionally RB cord-010119-t1x9gknd 6042 2 a a DT cord-010119-t1x9gknd 6042 3 reaction reaction NN cord-010119-t1x9gknd 6042 4 peak peak NN cord-010119-t1x9gknd 6042 5 was be VBD cord-010119-t1x9gknd 6042 6 insufficient insufficient JJ cord-010119-t1x9gknd 6042 7 to to TO cord-010119-t1x9gknd 6042 8 trigger trigger VB cord-010119-t1x9gknd 6042 9 the the DT cord-010119-t1x9gknd 6042 10 software software NN cord-010119-t1x9gknd 6042 11 automatic automatic JJ cord-010119-t1x9gknd 6042 12 allele allele NN cord-010119-t1x9gknd 6042 13 call call NN cord-010119-t1x9gknd 6042 14 and and CC cord-010119-t1x9gknd 6042 15 a a DT cord-010119-t1x9gknd 6042 16 manual manual JJ cord-010119-t1x9gknd 6042 17 interpretation interpretation NN cord-010119-t1x9gknd 6042 18 was be VBD cord-010119-t1x9gknd 6042 19 required require VBN cord-010119-t1x9gknd 6042 20 . . . cord-010119-t1x9gknd 6043 1 This this DT cord-010119-t1x9gknd 6043 2 occurred occur VBD cord-010119-t1x9gknd 6043 3 most most RBS cord-010119-t1x9gknd 6043 4 commonly commonly RB cord-010119-t1x9gknd 6043 5 with with IN cord-010119-t1x9gknd 6043 6 the the DT cord-010119-t1x9gknd 6043 7 HPA-3 HPA-3 NNPS cord-010119-t1x9gknd 6043 8 ( ( -LRB- cord-010119-t1x9gknd 6043 9 4.7 4.7 CD cord-010119-t1x9gknd 6043 10 % % NN cord-010119-t1x9gknd 6043 11 ) ) -RRB- cord-010119-t1x9gknd 6043 12 and and CC cord-010119-t1x9gknd 6044 1 HPA-5 hpa-5 NN cord-010119-t1x9gknd 6044 2 ( ( -LRB- cord-010119-t1x9gknd 6044 3 1.2 1.2 CD cord-010119-t1x9gknd 6044 4 % % NN cord-010119-t1x9gknd 6044 5 ) ) -RRB- cord-010119-t1x9gknd 6044 6 assays assay NNS cord-010119-t1x9gknd 6044 7 . . . cord-010119-t1x9gknd 6045 1 Conclusion conclusion NN cord-010119-t1x9gknd 6045 2 : : : cord-010119-t1x9gknd 6046 1 Real real JJ cord-010119-t1x9gknd 6046 2 - - HYPH cord-010119-t1x9gknd 6046 3 Time time NN cord-010119-t1x9gknd 6046 4 PCR PCR NNP cord-010119-t1x9gknd 6046 5 with with IN cord-010119-t1x9gknd 6046 6 automated automate VBN cord-010119-t1x9gknd 6046 7 analysis analysis NN cord-010119-t1x9gknd 6046 8 provides provide VBZ cord-010119-t1x9gknd 6046 9 an an DT cord-010119-t1x9gknd 6046 10 effective effective JJ cord-010119-t1x9gknd 6046 11 , , , cord-010119-t1x9gknd 6046 12 robust robust JJ cord-010119-t1x9gknd 6046 13 an an DT cord-010119-t1x9gknd 6046 14 accurate accurate JJ cord-010119-t1x9gknd 6046 15 method method NN cord-010119-t1x9gknd 6046 16 for for IN cord-010119-t1x9gknd 6046 17 molecular molecular JJ cord-010119-t1x9gknd 6046 18 HPA HPA NNP cord-010119-t1x9gknd 6046 19 genotyping genotyping NN cord-010119-t1x9gknd 6046 20 . . . cord-010119-t1x9gknd 6047 1 With with IN cord-010119-t1x9gknd 6047 2 its -PRON- PRP$ cord-010119-t1x9gknd 6047 3 minimal minimal JJ cord-010119-t1x9gknd 6047 4 hands hand NNS cord-010119-t1x9gknd 6047 5 - - HYPH cord-010119-t1x9gknd 6047 6 on on RP cord-010119-t1x9gknd 6047 7 time time NN cord-010119-t1x9gknd 6047 8 workflow workflow NN cord-010119-t1x9gknd 6047 9 , , , cord-010119-t1x9gknd 6047 10 it -PRON- PRP cord-010119-t1x9gknd 6047 11 is be VBZ cord-010119-t1x9gknd 6047 12 also also RB cord-010119-t1x9gknd 6047 13 very very RB cord-010119-t1x9gknd 6047 14 easy easy JJ cord-010119-t1x9gknd 6047 15 to to TO cord-010119-t1x9gknd 6047 16 implement implement VB cord-010119-t1x9gknd 6047 17 and and CC cord-010119-t1x9gknd 6047 18 offers offer VBZ cord-010119-t1x9gknd 6047 19 a a DT cord-010119-t1x9gknd 6047 20 cost cost NN cord-010119-t1x9gknd 6047 21 effective effective JJ cord-010119-t1x9gknd 6047 22 alternative alternative NN cord-010119-t1x9gknd 6047 23 to to IN cord-010119-t1x9gknd 6047 24 classical classical JJ cord-010119-t1x9gknd 6047 25 methods method NNS cord-010119-t1x9gknd 6047 26 used use VBN cord-010119-t1x9gknd 6047 27 in in IN cord-010119-t1x9gknd 6047 28 a a DT cord-010119-t1x9gknd 6047 29 transfusion transfusion NN cord-010119-t1x9gknd 6047 30 laboratory laboratory NN cord-010119-t1x9gknd 6047 31 setting setting NN cord-010119-t1x9gknd 6047 32 . . . cord-010119-t1x9gknd 6048 1 Genetic genetic JJ cord-010119-t1x9gknd 6048 2 Variation variation NN cord-010119-t1x9gknd 6048 3 of of IN cord-010119-t1x9gknd 6048 4 CD36 CD36 NNP cord-010119-t1x9gknd 6048 5 Antigen Antigen NNP cord-010119-t1x9gknd 6048 6 Deficiency Deficiency NNP cord-010119-t1x9gknd 6048 7 Expression expression NN cord-010119-t1x9gknd 6048 8 in in IN cord-010119-t1x9gknd 6048 9 Jiangsu Jiangsu NNP cord-010119-t1x9gknd 6048 10 Chinese chinese JJ cord-010119-t1x9gknd 6048 11 Han Han NNP cord-010119-t1x9gknd 6048 12 Population Population NNP cord-010119-t1x9gknd 6049 1 Qing Qing NNP cord-010119-t1x9gknd 6049 2 Chen Chen NNP cord-010119-t1x9gknd 6050 1 * * NFP cord-010119-t1x9gknd 6050 2 1 1 CD cord-010119-t1x9gknd 6050 3 , , , cord-010119-t1x9gknd 6050 4 Jianyu Jianyu NNP cord-010119-t1x9gknd 6050 5 Xiao Xiao NNP cord-010119-t1x9gknd 6050 6 1 1 CD cord-010119-t1x9gknd 6050 7 and and CC cord-010119-t1x9gknd 6050 8 Chengyin Chengyin NNP cord-010119-t1x9gknd 6050 9 Huang Huang NNP cord-010119-t1x9gknd 6050 10 2 2 CD cord-010119-t1x9gknd 6050 11 . . . cord-010119-t1x9gknd 6051 1 1 1 LS cord-010119-t1x9gknd 6052 1 Jiangsu Jiangsu NNP cord-010119-t1x9gknd 6052 2 Province Province NNP cord-010119-t1x9gknd 6052 3 Blood Blood NNP cord-010119-t1x9gknd 6052 4 Center Center NNP cord-010119-t1x9gknd 6052 5 , , , cord-010119-t1x9gknd 6052 6 2 2 CD cord-010119-t1x9gknd 6052 7 Jiangsu Jiangsu NNP cord-010119-t1x9gknd 6052 8 province province NN cord-010119-t1x9gknd 6052 9 Blood Blood NNP cord-010119-t1x9gknd 6052 10 Center Center NNP cord-010119-t1x9gknd 6052 11 Background Background NNP cord-010119-t1x9gknd 6052 12 / / SYM cord-010119-t1x9gknd 6052 13 Case Case NNP cord-010119-t1x9gknd 6052 14 Studies Studies NNPS cord-010119-t1x9gknd 6052 15 : : : cord-010119-t1x9gknd 6053 1 CD36 CD36 NNP cord-010119-t1x9gknd 6053 2 has have VBZ cord-010119-t1x9gknd 6053 3 been be VBN cord-010119-t1x9gknd 6053 4 implicated implicate VBN cord-010119-t1x9gknd 6053 5 in in IN cord-010119-t1x9gknd 6053 6 the the DT cord-010119-t1x9gknd 6053 7 platelet platelet NN cord-010119-t1x9gknd 6053 8 refractoriness refractoriness NN cord-010119-t1x9gknd 6053 9 , , , cord-010119-t1x9gknd 6053 10 neonatal neonatal JJ cord-010119-t1x9gknd 6053 11 alloimmune alloimmune JJ cord-010119-t1x9gknd 6053 12 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 6053 13 , , , cord-010119-t1x9gknd 6053 14 and and CC cord-010119-t1x9gknd 6053 15 posttransfusion posttransfusion NNP cord-010119-t1x9gknd 6053 16 purpura purpura NN cord-010119-t1x9gknd 6053 17 , , , cord-010119-t1x9gknd 6053 18 especially especially RB cord-010119-t1x9gknd 6053 19 in in IN cord-010119-t1x9gknd 6053 20 the the DT cord-010119-t1x9gknd 6053 21 non non JJ cord-010119-t1x9gknd 6053 22 - - JJ cord-010119-t1x9gknd 6053 23 Caucasian caucasian JJ cord-010119-t1x9gknd 6053 24 . . . cord-010119-t1x9gknd 6054 1 CD36 CD36 NNP cord-010119-t1x9gknd 6054 2 deficiency deficiency NN cord-010119-t1x9gknd 6054 3 varies vary VBZ cord-010119-t1x9gknd 6054 4 widely widely RB cord-010119-t1x9gknd 6054 5 among among IN cord-010119-t1x9gknd 6054 6 different different JJ cord-010119-t1x9gknd 6054 7 ethnic ethnic JJ cord-010119-t1x9gknd 6054 8 populations population NNS cord-010119-t1x9gknd 6054 9 , , , cord-010119-t1x9gknd 6054 10 with with IN cord-010119-t1x9gknd 6054 11 the the DT cord-010119-t1x9gknd 6054 12 frequency frequency NN cord-010119-t1x9gknd 6054 13 of of IN cord-010119-t1x9gknd 6054 14 3 3 CD cord-010119-t1x9gknd 6054 15 - - SYM cord-010119-t1x9gknd 6054 16 11 11 CD cord-010119-t1x9gknd 6054 17 % % NN cord-010119-t1x9gknd 6054 18 in in IN cord-010119-t1x9gknd 6054 19 Asians Asians NNPS cord-010119-t1x9gknd 6054 20 and and CC cord-010119-t1x9gknd 6054 21 2.4 2.4 CD cord-010119-t1x9gknd 6054 22 % % NN cord-010119-t1x9gknd 6054 23 of of IN cord-010119-t1x9gknd 6054 24 African african JJ cord-010119-t1x9gknd 6054 25 Americans Americans NNPS cord-010119-t1x9gknd 6054 26 , , , cord-010119-t1x9gknd 6054 27 respectively respectively RB cord-010119-t1x9gknd 6054 28 . . . cord-010119-t1x9gknd 6055 1 However however RB cord-010119-t1x9gknd 6055 2 , , , cord-010119-t1x9gknd 6055 3 there there EX cord-010119-t1x9gknd 6055 4 is be VBZ cord-010119-t1x9gknd 6055 5 little little JJ cord-010119-t1x9gknd 6055 6 information information NN cord-010119-t1x9gknd 6055 7 on on IN cord-010119-t1x9gknd 6055 8 the the DT cord-010119-t1x9gknd 6055 9 molecular molecular JJ cord-010119-t1x9gknd 6055 10 basis basis NN cord-010119-t1x9gknd 6055 11 of of IN cord-010119-t1x9gknd 6055 12 individuals individual NNS cord-010119-t1x9gknd 6055 13 with with IN cord-010119-t1x9gknd 6055 14 CD36 CD36 NNP cord-010119-t1x9gknd 6055 15 deficiency deficiency NN cord-010119-t1x9gknd 6055 16 in in IN cord-010119-t1x9gknd 6055 17 Jiangsu Jiangsu NNP cord-010119-t1x9gknd 6055 18 Chinese chinese JJ cord-010119-t1x9gknd 6055 19 Han Han NNP cord-010119-t1x9gknd 6055 20 population population NN cord-010119-t1x9gknd 6055 21 . . . cord-010119-t1x9gknd 6056 1 Study Study NNP cord-010119-t1x9gknd 6056 2 Design Design NNP cord-010119-t1x9gknd 6056 3 / / SYM cord-010119-t1x9gknd 6056 4 Method method NN cord-010119-t1x9gknd 6056 5 : : : cord-010119-t1x9gknd 6057 1 To to TO cord-010119-t1x9gknd 6057 2 investigate investigate VB cord-010119-t1x9gknd 6057 3 platelet platelet NN cord-010119-t1x9gknd 6057 4 CD36 CD36 NNP cord-010119-t1x9gknd 6057 5 expression expression NN cord-010119-t1x9gknd 6057 6 levels level NNS cord-010119-t1x9gknd 6057 7 and and CC cord-010119-t1x9gknd 6057 8 to to TO cord-010119-t1x9gknd 6057 9 determine determine VB cord-010119-t1x9gknd 6057 10 the the DT cord-010119-t1x9gknd 6057 11 molecular molecular JJ cord-010119-t1x9gknd 6057 12 basis basis NN cord-010119-t1x9gknd 6057 13 of of IN cord-010119-t1x9gknd 6057 14 CD36 CD36 NNP cord-010119-t1x9gknd 6057 15 deficiency deficiency NN cord-010119-t1x9gknd 6057 16 on on IN cord-010119-t1x9gknd 6057 17 the the DT cord-010119-t1x9gknd 6057 18 platelet platelet NN cord-010119-t1x9gknd 6057 19 surface surface NN cord-010119-t1x9gknd 6057 20 of of IN cord-010119-t1x9gknd 6057 21 the the DT cord-010119-t1x9gknd 6057 22 Han Han NNP cord-010119-t1x9gknd 6057 23 population population NN cord-010119-t1x9gknd 6057 24 in in IN cord-010119-t1x9gknd 6057 25 Jiangsu Jiangsu NNP cord-010119-t1x9gknd 6057 26 region region NN cord-010119-t1x9gknd 6057 27 . . . cord-010119-t1x9gknd 6058 1 CD36 CD36 NNP cord-010119-t1x9gknd 6058 2 expression expression NN cord-010119-t1x9gknd 6058 3 levels level NNS cord-010119-t1x9gknd 6058 4 on on IN cord-010119-t1x9gknd 6058 5 platelets platelet NNS cord-010119-t1x9gknd 6058 6 were be VBD cord-010119-t1x9gknd 6058 7 detected detect VBN cord-010119-t1x9gknd 6058 8 by by IN cord-010119-t1x9gknd 6058 9 flow flow NN cord-010119-t1x9gknd 6058 10 cytometry cytometry NN cord-010119-t1x9gknd 6058 11 among among IN cord-010119-t1x9gknd 6058 12 243 243 CD cord-010119-t1x9gknd 6058 13 blood blood NN cord-010119-t1x9gknd 6058 14 donors donor NNS cord-010119-t1x9gknd 6058 15 in in IN cord-010119-t1x9gknd 6058 16 Jiangsu Jiangsu NNP cord-010119-t1x9gknd 6058 17 region region NN cord-010119-t1x9gknd 6058 18 . . . cord-010119-t1x9gknd 6059 1 Donors donor NNS cord-010119-t1x9gknd 6059 2 without without IN cord-010119-t1x9gknd 6059 3 CD36 CD36 NNP cord-010119-t1x9gknd 6059 4 antigen antigen NN cord-010119-t1x9gknd 6059 5 expression expression NN cord-010119-t1x9gknd 6059 6 on on IN cord-010119-t1x9gknd 6059 7 their -PRON- PRP$ cord-010119-t1x9gknd 6059 8 platelet platelet NN cord-010119-t1x9gknd 6059 9 surface surface NN cord-010119-t1x9gknd 6059 10 were be VBD cord-010119-t1x9gknd 6059 11 further further JJ cord-010119-t1x9gknd 6059 12 to to TO cord-010119-t1x9gknd 6059 13 be be VB cord-010119-t1x9gknd 6059 14 determined determine VBN cord-010119-t1x9gknd 6059 15 the the DT cord-010119-t1x9gknd 6059 16 expression expression NN cord-010119-t1x9gknd 6059 17 of of IN cord-010119-t1x9gknd 6059 18 CD36 CD36 NNP cord-010119-t1x9gknd 6059 19 antigen antigen NN cord-010119-t1x9gknd 6059 20 on on IN cord-010119-t1x9gknd 6059 21 their -PRON- PRP$ cord-010119-t1x9gknd 6059 22 peripheral peripheral JJ cord-010119-t1x9gknd 6059 23 blood blood NN cord-010119-t1x9gknd 6059 24 monocyte monocyte NNP cord-010119-t1x9gknd 6059 25 cells cell NNS cord-010119-t1x9gknd 6059 26 . . . cord-010119-t1x9gknd 6060 1 The the DT cord-010119-t1x9gknd 6060 2 coding code VBG cord-010119-t1x9gknd 6060 3 exons exon NNS cord-010119-t1x9gknd 6060 4 of of IN cord-010119-t1x9gknd 6060 5 CD36 CD36 NNP cord-010119-t1x9gknd 6060 6 gene gene NN cord-010119-t1x9gknd 6060 7 and and CC cord-010119-t1x9gknd 6060 8 adjacent adjacent JJ cord-010119-t1x9gknd 6060 9 introns intron NNS cord-010119-t1x9gknd 6060 10 were be VBD cord-010119-t1x9gknd 6060 11 amplified amplify VBN cord-010119-t1x9gknd 6060 12 and and CC cord-010119-t1x9gknd 6060 13 sequenced sequence VBN cord-010119-t1x9gknd 6060 14 in in IN cord-010119-t1x9gknd 6060 15 CD36 CD36 NNP cord-010119-t1x9gknd 6060 16 deficient deficient JJ cord-010119-t1x9gknd 6060 17 individuals individual NNS cord-010119-t1x9gknd 6060 18 . . . cord-010119-t1x9gknd 6061 1 Results result NNS cord-010119-t1x9gknd 6061 2 / / SYM cord-010119-t1x9gknd 6061 3 Finding finding NN cord-010119-t1x9gknd 6061 4 : : : cord-010119-t1x9gknd 6062 1 Among among IN cord-010119-t1x9gknd 6062 2 these these DT cord-010119-t1x9gknd 6062 3 243 243 CD cord-010119-t1x9gknd 6062 4 blood blood NN cord-010119-t1x9gknd 6062 5 donors donor NNS cord-010119-t1x9gknd 6062 6 , , , cord-010119-t1x9gknd 6062 7 CD36-deficient CD36-deficient NNP cord-010119-t1x9gknd 6062 8 and and CC cord-010119-t1x9gknd 6062 9 CD36-expression cd36-expression CD cord-010119-t1x9gknd 6062 10 individuals individual NNS cord-010119-t1x9gknd 6062 11 were be VBD cord-010119-t1x9gknd 6062 12 2.47 2.47 CD cord-010119-t1x9gknd 6062 13 % % NN cord-010119-t1x9gknd 6062 14 ( ( -LRB- cord-010119-t1x9gknd 6062 15 6/243 6/243 CD cord-010119-t1x9gknd 6062 16 ) ) -RRB- cord-010119-t1x9gknd 6062 17 and and CC cord-010119-t1x9gknd 6062 18 97.53 97.53 CD cord-010119-t1x9gknd 6062 19 % % NN cord-010119-t1x9gknd 6062 20 ( ( -LRB- cord-010119-t1x9gknd 6062 21 237/243 237/243 CD cord-010119-t1x9gknd 6062 22 ) ) -RRB- cord-010119-t1x9gknd 6062 23 , , , cord-010119-t1x9gknd 6062 24 respectively respectively RB cord-010119-t1x9gknd 6062 25 . . . cord-010119-t1x9gknd 6063 1 The the DT cord-010119-t1x9gknd 6063 2 frequencies frequency NNS cord-010119-t1x9gknd 6063 3 of of IN cord-010119-t1x9gknd 6063 4 Type type NN cord-010119-t1x9gknd 6063 5 I I NNP cord-010119-t1x9gknd 6063 6 and and CC cord-010119-t1x9gknd 6063 7 Type Type NNP cord-010119-t1x9gknd 6063 8 II II NNP cord-010119-t1x9gknd 6063 9 CD36 CD36 NNP cord-010119-t1x9gknd 6063 10 deficiency deficiency NN cord-010119-t1x9gknd 6063 11 among among IN cord-010119-t1x9gknd 6063 12 the the DT cord-010119-t1x9gknd 6063 13 study study NN cord-010119-t1x9gknd 6063 14 population population NN cord-010119-t1x9gknd 6063 15 were be VBD cord-010119-t1x9gknd 6063 16 0.41 0.41 CD cord-010119-t1x9gknd 6063 17 % % NN cord-010119-t1x9gknd 6063 18 ( ( -LRB- cord-010119-t1x9gknd 6063 19 1/243 1/243 CD cord-010119-t1x9gknd 6063 20 ) ) -RRB- cord-010119-t1x9gknd 6063 21 and and CC cord-010119-t1x9gknd 6063 22 2.06 2.06 CD cord-010119-t1x9gknd 6063 23 % % NN cord-010119-t1x9gknd 6063 24 ( ( -LRB- cord-010119-t1x9gknd 6063 25 5/243 5/243 CD cord-010119-t1x9gknd 6063 26 ) ) -RRB- cord-010119-t1x9gknd 6063 27 , , , cord-010119-t1x9gknd 6063 28 respectively respectively RB cord-010119-t1x9gknd 6063 29 . . . cord-010119-t1x9gknd 6064 1 Among among IN cord-010119-t1x9gknd 6064 2 237 237 CD cord-010119-t1x9gknd 6064 3 individual individual NN cord-010119-t1x9gknd 6064 4 with with IN cord-010119-t1x9gknd 6064 5 platelet platelet NN cord-010119-t1x9gknd 6064 6 CD36 CD36 NNP cord-010119-t1x9gknd 6064 7 expression expression NN cord-010119-t1x9gknd 6064 8 , , , cord-010119-t1x9gknd 6064 9 according accord VBG cord-010119-t1x9gknd 6064 10 to to IN cord-010119-t1x9gknd 6064 11 mean mean VB cord-010119-t1x9gknd 6064 12 fluorescence fluorescence NN cord-010119-t1x9gknd 6064 13 intensity intensity NN cord-010119-t1x9gknd 6064 14 ( ( -LRB- cord-010119-t1x9gknd 6064 15 MFI MFI NNP cord-010119-t1x9gknd 6064 16 ) ) -RRB- cord-010119-t1x9gknd 6064 17 value value NN cord-010119-t1x9gknd 6064 18 , , , cord-010119-t1x9gknd 6064 19 45 45 CD cord-010119-t1x9gknd 6064 20 , , , cord-010119-t1x9gknd 6064 21 141 141 CD cord-010119-t1x9gknd 6064 22 and and CC cord-010119-t1x9gknd 6064 23 51 51 CD cord-010119-t1x9gknd 6064 24 individuals individual NNS cord-010119-t1x9gknd 6064 25 showed show VBD cord-010119-t1x9gknd 6064 26 low low JJ cord-010119-t1x9gknd 6064 27 , , , cord-010119-t1x9gknd 6064 28 moderate moderate JJ cord-010119-t1x9gknd 6064 29 and and CC cord-010119-t1x9gknd 6064 30 high high JJ cord-010119-t1x9gknd 6064 31 expression expression NN cord-010119-t1x9gknd 6064 32 levels level NNS cord-010119-t1x9gknd 6064 33 of of IN cord-010119-t1x9gknd 6064 34 CD36 CD36 NNP cord-010119-t1x9gknd 6064 35 , , , cord-010119-t1x9gknd 6064 36 respectively respectively RB cord-010119-t1x9gknd 6064 37 , , , cord-010119-t1x9gknd 6064 38 and and CC cord-010119-t1x9gknd 6064 39 their -PRON- PRP$ cord-010119-t1x9gknd 6064 40 MFIs mfi NNS cord-010119-t1x9gknd 6064 41 were be VBD cord-010119-t1x9gknd 6064 42 1725.9 1725.9 CD cord-010119-t1x9gknd 6064 43 6 6 CD cord-010119-t1x9gknd 6064 44 343.6 343.6 CD cord-010119-t1x9gknd 6064 45 , , , cord-010119-t1x9gknd 6064 46 3876.1 3876.1 CD cord-010119-t1x9gknd 6064 47 6 6 CD cord-010119-t1x9gknd 6064 48 788.5 788.5 CD cord-010119-t1x9gknd 6064 49 and and CC cord-010119-t1x9gknd 6064 50 8431.6 8431.6 CD cord-010119-t1x9gknd 6064 51 6 6 CD cord-010119-t1x9gknd 6064 52 529.9 529.9 CD cord-010119-t1x9gknd 6064 53 ( ( -LRB- cord-010119-t1x9gknd 6064 54 P<0.05 P<0.05 NNS cord-010119-t1x9gknd 6064 55 ) ) -RRB- cord-010119-t1x9gknd 6064 56 , , , cord-010119-t1x9gknd 6064 57 respectively respectively RB cord-010119-t1x9gknd 6064 58 . . . cord-010119-t1x9gknd 6065 1 The the DT cord-010119-t1x9gknd 6065 2 type type NN cord-010119-t1x9gknd 6065 3 I -PRON- PRP cord-010119-t1x9gknd 6065 4 CD36 CD36 NNP cord-010119-t1x9gknd 6065 5 deficiency deficiency NN cord-010119-t1x9gknd 6065 6 individual individual NN cord-010119-t1x9gknd 6065 7 were be VBD cord-010119-t1x9gknd 6065 8 heterozygous heterozygous JJ cord-010119-t1x9gknd 6065 9 for for IN cord-010119-t1x9gknd 6065 10 1200 1200 CD cord-010119-t1x9gknd 6065 11 - - HYPH cord-010119-t1x9gknd 6065 12 13A 13a CD cord-010119-t1x9gknd 6065 13 > > XX cord-010119-t1x9gknd 6065 14 G g NN cord-010119-t1x9gknd 6065 15 and and CC cord-010119-t1x9gknd 6065 16 430 430 CD cord-010119-t1x9gknd 6065 17 - - HYPH cord-010119-t1x9gknd 6065 18 14C 14c NN cord-010119-t1x9gknd 6065 19 > > XX cord-010119-t1x9gknd 6065 20 G g NN cord-010119-t1x9gknd 6065 21 , , , cord-010119-t1x9gknd 6065 22 respectively respectively RB cord-010119-t1x9gknd 6065 23 . . . cord-010119-t1x9gknd 6066 1 Among among IN cord-010119-t1x9gknd 6066 2 Type Type NNP cord-010119-t1x9gknd 6066 3 II II NNP cord-010119-t1x9gknd 6066 4 CD36 CD36 NNP cord-010119-t1x9gknd 6066 5 deficiency deficiency NN cord-010119-t1x9gknd 6066 6 individuals individual NNS cord-010119-t1x9gknd 6066 7 , , , cord-010119-t1x9gknd 6066 8 two two CD cord-010119-t1x9gknd 6066 9 harbored harbor VBD cord-010119-t1x9gknd 6066 10 a a DT cord-010119-t1x9gknd 6066 11 T t NN cord-010119-t1x9gknd 6066 12 insertion insertion NN cord-010119-t1x9gknd 6066 13 at at IN cord-010119-t1x9gknd 6066 14 position position NN cord-010119-t1x9gknd 6066 15 560 560 CD cord-010119-t1x9gknd 6066 16 in in IN cord-010119-t1x9gknd 6066 17 exon exon NN cord-010119-t1x9gknd 6066 18 6 6 CD cord-010119-t1x9gknd 6066 19 which which WDT cord-010119-t1x9gknd 6066 20 caused cause VBD cord-010119-t1x9gknd 6066 21 frameshift frameshift NN cord-010119-t1x9gknd 6066 22 at at IN cord-010119-t1x9gknd 6066 23 codon codon NN cord-010119-t1x9gknd 6066 24 187 187 CD cord-010119-t1x9gknd 6066 25 ; ; : cord-010119-t1x9gknd 6066 26 one one PRP cord-010119-t1x9gknd 6066 27 has have VBZ cord-010119-t1x9gknd 6066 28 a a DT cord-010119-t1x9gknd 6066 29 T t NN cord-010119-t1x9gknd 6066 30 > > XX cord-010119-t1x9gknd 6066 31 C c NN cord-010119-t1x9gknd 6066 32 exchange exchange NN cord-010119-t1x9gknd 6066 33 at at IN cord-010119-t1x9gknd 6066 34 position position NN cord-010119-t1x9gknd 6066 35 538 538 CD cord-010119-t1x9gknd 6066 36 in in IN cord-010119-t1x9gknd 6066 37 exon exon NN cord-010119-t1x9gknd 6066 38 6 6 CD cord-010119-t1x9gknd 6066 39 which which WDT cord-010119-t1x9gknd 6066 40 resulted result VBD cord-010119-t1x9gknd 6066 41 in in IN cord-010119-t1x9gknd 6066 42 a a DT cord-010119-t1x9gknd 6066 43 tryptophan tryptophan NN cord-010119-t1x9gknd 6066 44 to to IN cord-010119-t1x9gknd 6066 45 arginine arginine NN cord-010119-t1x9gknd 6066 46 substitution substitution NN cord-010119-t1x9gknd 6066 47 at at IN cord-010119-t1x9gknd 6066 48 codon codon NN cord-010119-t1x9gknd 6066 49 180 180 CD cord-010119-t1x9gknd 6066 50 ; ; : cord-010119-t1x9gknd 6066 51 one one PRP cord-010119-t1x9gknd 6066 52 has have VBZ cord-010119-t1x9gknd 6066 53 a a DT cord-010119-t1x9gknd 6066 54 A a DT cord-010119-t1x9gknd 6066 55 insertion insertion NN cord-010119-t1x9gknd 6066 56 before before IN cord-010119-t1x9gknd 6066 57 the the DT cord-010119-t1x9gknd 6066 58 17th 17th JJ cord-010119-t1x9gknd 6066 59 bp bp NNP cord-010119-t1x9gknd 6066 60 of of IN cord-010119-t1x9gknd 6066 61 the the DT cord-010119-t1x9gknd 6066 62 start start NN cord-010119-t1x9gknd 6066 63 codon codon NN cord-010119-t1x9gknd 6066 64 ATG ATG NNP cord-010119-t1x9gknd 6066 65 in in IN cord-010119-t1x9gknd 6066 66 the the DT cord-010119-t1x9gknd 6066 67 promoter promoter NN cord-010119-t1x9gknd 6066 68 region region NN cord-010119-t1x9gknd 6066 69 ; ; : cord-010119-t1x9gknd 6066 70 one one CD cord-010119-t1x9gknd 6066 71 were be VBD cord-010119-t1x9gknd 6066 72 heterozygous heterozygous JJ cord-010119-t1x9gknd 6066 73 for for IN cord-010119-t1x9gknd 6066 74 748 748 CD cord-010119-t1x9gknd 6066 75 1 1 CD cord-010119-t1x9gknd 6066 76 2 2 CD cord-010119-t1x9gknd 6066 77 T t NN cord-010119-t1x9gknd 6066 78 > > XX cord-010119-t1x9gknd 6067 1 C C NNP cord-010119-t1x9gknd 6067 2 and and CC cord-010119-t1x9gknd 6067 3 1006 1006 CD cord-010119-t1x9gknd 6067 4 1 1 CD cord-010119-t1x9gknd 6067 5 2T 2t NN cord-010119-t1x9gknd 6067 6 > > XX cord-010119-t1x9gknd 6067 7 G g NN cord-010119-t1x9gknd 6067 8 , , , cord-010119-t1x9gknd 6067 9 respectively respectively RB cord-010119-t1x9gknd 6067 10 . . . cord-010119-t1x9gknd 6068 1 Conclusion conclusion NN cord-010119-t1x9gknd 6068 2 : : : cord-010119-t1x9gknd 6068 3 Platelet platelet NN cord-010119-t1x9gknd 6068 4 CD36 CD36 NNP cord-010119-t1x9gknd 6068 5 surface surface NN cord-010119-t1x9gknd 6068 6 expression expression NN cord-010119-t1x9gknd 6068 7 levels level NNS cord-010119-t1x9gknd 6068 8 were be VBD cord-010119-t1x9gknd 6068 9 diversified diversify VBN cord-010119-t1x9gknd 6068 10 in in IN cord-010119-t1x9gknd 6068 11 the the DT cord-010119-t1x9gknd 6068 12 Jiangsu Jiangsu NNP cord-010119-t1x9gknd 6068 13 Chinese chinese JJ cord-010119-t1x9gknd 6068 14 Han Han NNP cord-010119-t1x9gknd 6068 15 population population NN cord-010119-t1x9gknd 6068 16 . . . cord-010119-t1x9gknd 6069 1 The the DT cord-010119-t1x9gknd 6069 2 frequency frequency NN cord-010119-t1x9gknd 6069 3 of of IN cord-010119-t1x9gknd 6069 4 the the DT cord-010119-t1x9gknd 6069 5 Type Type NNP cord-010119-t1x9gknd 6069 6 II II NNP cord-010119-t1x9gknd 6069 7 CD36 CD36 NNP cord-010119-t1x9gknd 6069 8 deficiency deficiency NN cord-010119-t1x9gknd 6069 9 was be VBD cord-010119-t1x9gknd 6069 10 higher high JJR cord-010119-t1x9gknd 6069 11 than than IN cord-010119-t1x9gknd 6069 12 that that DT cord-010119-t1x9gknd 6069 13 in in IN cord-010119-t1x9gknd 6069 14 Type type NN cord-010119-t1x9gknd 6069 15 I. i. NN cord-010119-t1x9gknd 6070 1 The the DT cord-010119-t1x9gknd 6070 2 study study NN cord-010119-t1x9gknd 6070 3 findings finding NNS cord-010119-t1x9gknd 6070 4 indicated indicate VBD cord-010119-t1x9gknd 6070 5 that that IN cord-010119-t1x9gknd 6070 6 the the DT cord-010119-t1x9gknd 6070 7 frequency frequency NN cord-010119-t1x9gknd 6070 8 of of IN cord-010119-t1x9gknd 6070 9 CD36 CD36 NNP cord-010119-t1x9gknd 6070 10 deficiency deficiency NN cord-010119-t1x9gknd 6070 11 in in IN cord-010119-t1x9gknd 6070 12 the the DT cord-010119-t1x9gknd 6070 13 Chinese chinese JJ cord-010119-t1x9gknd 6070 14 population population NN cord-010119-t1x9gknd 6070 15 is be VBZ cord-010119-t1x9gknd 6070 16 slightly slightly RB cord-010119-t1x9gknd 6070 17 lower low JJR cord-010119-t1x9gknd 6070 18 than than IN cord-010119-t1x9gknd 6070 19 that that DT cord-010119-t1x9gknd 6070 20 in in IN cord-010119-t1x9gknd 6070 21 other other JJ cord-010119-t1x9gknd 6070 22 Asian asian JJ cord-010119-t1x9gknd 6070 23 countries country NNS cord-010119-t1x9gknd 6070 24 . . . cord-010119-t1x9gknd 6071 1 Background Background NNP cord-010119-t1x9gknd 6071 2 / / SYM cord-010119-t1x9gknd 6071 3 Case Case NNP cord-010119-t1x9gknd 6071 4 Studies Studies NNPS cord-010119-t1x9gknd 6071 5 : : : cord-010119-t1x9gknd 6072 1 CD36-deficient cd36-deficient CD cord-010119-t1x9gknd 6072 2 phenotype phenotype NN cord-010119-t1x9gknd 6072 3 can can MD cord-010119-t1x9gknd 6072 4 be be VB cord-010119-t1x9gknd 6072 5 immunized immunize VBN cord-010119-t1x9gknd 6072 6 by by IN cord-010119-t1x9gknd 6072 7 pregnancy pregnancy NN cord-010119-t1x9gknd 6072 8 or or CC cord-010119-t1x9gknd 6072 9 transfusion transfusion NN cord-010119-t1x9gknd 6072 10 , , , cord-010119-t1x9gknd 6072 11 and and CC cord-010119-t1x9gknd 6072 12 involved involve VBN cord-010119-t1x9gknd 6072 13 in in IN cord-010119-t1x9gknd 6072 14 neonatal neonatal JJ cord-010119-t1x9gknd 6072 15 alloimmune alloimmune JJ cord-010119-t1x9gknd 6072 16 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 6072 17 , , , cord-010119-t1x9gknd 6072 18 platelet platelet NN cord-010119-t1x9gknd 6072 19 transfusion transfusion NN cord-010119-t1x9gknd 6072 20 refractoriness refractoriness NN cord-010119-t1x9gknd 6072 21 and and CC cord-010119-t1x9gknd 6072 22 other other JJ cord-010119-t1x9gknd 6072 23 disorders disorder NNS cord-010119-t1x9gknd 6072 24 . . . cord-010119-t1x9gknd 6073 1 The the DT cord-010119-t1x9gknd 6073 2 frequency frequency NN cord-010119-t1x9gknd 6073 3 of of IN cord-010119-t1x9gknd 6073 4 platelet platelet NN cord-010119-t1x9gknd 6073 5 CD36-deficient cd36-deficient CD cord-010119-t1x9gknd 6073 6 individuals individual NNS cord-010119-t1x9gknd 6073 7 widely widely RB cord-010119-t1x9gknd 6073 8 varies vary VBZ cord-010119-t1x9gknd 6073 9 among among IN cord-010119-t1x9gknd 6073 10 ethnic ethnic JJ cord-010119-t1x9gknd 6073 11 groups group NNS cord-010119-t1x9gknd 6073 12 , , , cord-010119-t1x9gknd 6073 13 with with IN cord-010119-t1x9gknd 6073 14 3 3 CD cord-010119-t1x9gknd 6073 15 % % NN cord-010119-t1x9gknd 6073 16 to to TO cord-010119-t1x9gknd 6073 17 11 11 CD cord-010119-t1x9gknd 6073 18 % % NN cord-010119-t1x9gknd 6073 19 in in IN cord-010119-t1x9gknd 6073 20 Japanese Japanese NNP cord-010119-t1x9gknd 6073 21 , , , cord-010119-t1x9gknd 6073 22 8 8 CD cord-010119-t1x9gknd 6073 23 % % NN cord-010119-t1x9gknd 6073 24 in in IN cord-010119-t1x9gknd 6073 25 sub sub JJ cord-010119-t1x9gknd 6073 26 - - JJ cord-010119-t1x9gknd 6073 27 Saharan saharan JJ cord-010119-t1x9gknd 6073 28 Africans Africans NNPS cord-010119-t1x9gknd 6073 29 , , , cord-010119-t1x9gknd 6073 30 2.4 2.4 CD cord-010119-t1x9gknd 6073 31 % % NN cord-010119-t1x9gknd 6073 32 in in IN cord-010119-t1x9gknd 6073 33 African african JJ cord-010119-t1x9gknd 6073 34 Americans Americans NNPS cord-010119-t1x9gknd 6073 35 , , , cord-010119-t1x9gknd 6073 36 and and CC cord-010119-t1x9gknd 6073 37 0.3 0.3 CD cord-010119-t1x9gknd 6073 38 % % NN cord-010119-t1x9gknd 6073 39 in in IN cord-010119-t1x9gknd 6073 40 Caucasians Caucasians NNPS cord-010119-t1x9gknd 6073 41 . . . cord-010119-t1x9gknd 6074 1 Although although IN cord-010119-t1x9gknd 6074 2 some some DT cord-010119-t1x9gknd 6074 3 studies study NNS cord-010119-t1x9gknd 6074 4 of of IN cord-010119-t1x9gknd 6074 5 CD36 CD36 NNP cord-010119-t1x9gknd 6074 6 deficiency deficiency NN cord-010119-t1x9gknd 6074 7 are be VBP cord-010119-t1x9gknd 6074 8 focused focus VBN cord-010119-t1x9gknd 6074 9 on on IN cord-010119-t1x9gknd 6074 10 the the DT cord-010119-t1x9gknd 6074 11 Asian asian JJ cord-010119-t1x9gknd 6074 12 populations population NNS cord-010119-t1x9gknd 6074 13 , , , cord-010119-t1x9gknd 6074 14 relatively relatively RB cord-010119-t1x9gknd 6074 15 little little JJ cord-010119-t1x9gknd 6074 16 information information NN cord-010119-t1x9gknd 6074 17 has have VBZ cord-010119-t1x9gknd 6074 18 been be VBN cord-010119-t1x9gknd 6074 19 reported report VBN cord-010119-t1x9gknd 6074 20 in in IN cord-010119-t1x9gknd 6074 21 the the DT cord-010119-t1x9gknd 6074 22 Chinese chinese JJ cord-010119-t1x9gknd 6074 23 population population NN cord-010119-t1x9gknd 6074 24 . . . cord-010119-t1x9gknd 6075 1 Here here RB cord-010119-t1x9gknd 6075 2 we -PRON- PRP cord-010119-t1x9gknd 6075 3 investigated investigate VBD cord-010119-t1x9gknd 6075 4 the the DT cord-010119-t1x9gknd 6075 5 CD36 CD36 NNP cord-010119-t1x9gknd 6075 6 expression expression NN cord-010119-t1x9gknd 6075 7 on on IN cord-010119-t1x9gknd 6075 8 platelets platelet NNS cord-010119-t1x9gknd 6075 9 in in IN cord-010119-t1x9gknd 6075 10 large large JJ cord-010119-t1x9gknd 6075 11 samples sample NNS cord-010119-t1x9gknd 6075 12 of of IN cord-010119-t1x9gknd 6075 13 the the DT cord-010119-t1x9gknd 6075 14 Eastern eastern JJ cord-010119-t1x9gknd 6075 15 Chinese chinese JJ cord-010119-t1x9gknd 6075 16 donors donor NNS cord-010119-t1x9gknd 6075 17 . . . cord-010119-t1x9gknd 6076 1 Study Study NNP cord-010119-t1x9gknd 6076 2 Design Design NNP cord-010119-t1x9gknd 6076 3 / / SYM cord-010119-t1x9gknd 6076 4 Methods method NNS cord-010119-t1x9gknd 6077 1 : : : cord-010119-t1x9gknd 6077 2 Peripheral peripheral JJ cord-010119-t1x9gknd 6077 3 blood blood NN cord-010119-t1x9gknd 6077 4 samples sample NNS cord-010119-t1x9gknd 6077 5 were be VBD cord-010119-t1x9gknd 6077 6 collected collect VBN cord-010119-t1x9gknd 6077 7 from from IN cord-010119-t1x9gknd 6077 8 1282 1282 CD cord-010119-t1x9gknd 6077 9 unrelated unrelated JJ cord-010119-t1x9gknd 6077 10 platelet platelet NN cord-010119-t1x9gknd 6077 11 - - HYPH cord-010119-t1x9gknd 6077 12 apheresis apheresis NN cord-010119-t1x9gknd 6077 13 donors donor NNS cord-010119-t1x9gknd 6077 14 in in IN cord-010119-t1x9gknd 6077 15 the the DT cord-010119-t1x9gknd 6077 16 Eastern Eastern NNP cord-010119-t1x9gknd 6077 17 China China NNP cord-010119-t1x9gknd 6077 18 . . . cord-010119-t1x9gknd 6078 1 The the DT cord-010119-t1x9gknd 6078 2 expression expression NN cord-010119-t1x9gknd 6078 3 of of IN cord-010119-t1x9gknd 6078 4 CD36 CD36 NNP cord-010119-t1x9gknd 6078 5 antigen antigen NN cord-010119-t1x9gknd 6078 6 on on IN cord-010119-t1x9gknd 6078 7 platelets platelet NNS cord-010119-t1x9gknd 6078 8 was be VBD cord-010119-t1x9gknd 6078 9 determined determine VBN cord-010119-t1x9gknd 6078 10 by by IN cord-010119-t1x9gknd 6078 11 flow flow NN cord-010119-t1x9gknd 6078 12 cytometry cytometry NN cord-010119-t1x9gknd 6078 13 using use VBG cord-010119-t1x9gknd 6078 14 fluorescein fluorescein JJ cord-010119-t1x9gknd 6078 15 conjugated conjugate VBN cord-010119-t1x9gknd 6078 16 monoclonal monoclonal JJ cord-010119-t1x9gknd 6078 17 antibodies antibody NNS cord-010119-t1x9gknd 6078 18 ( ( -LRB- cord-010119-t1x9gknd 6078 19 FITC FITC NNP cord-010119-t1x9gknd 6078 20 - - HYPH cord-010119-t1x9gknd 6078 21 anti anti NNP cord-010119-t1x9gknd 6078 22 - - JJ cord-010119-t1x9gknd 6078 23 CD36 CD36 NNP cord-010119-t1x9gknd 6078 24 and and CC cord-010119-t1x9gknd 6078 25 PEanti PEanti NNP cord-010119-t1x9gknd 6078 26 - - HYPH cord-010119-t1x9gknd 6078 27 CD41 CD41 NNP cord-010119-t1x9gknd 6078 28 ) ) -RRB- cord-010119-t1x9gknd 6078 29 . . . cord-010119-t1x9gknd 6079 1 The the DT cord-010119-t1x9gknd 6079 2 isotype isotype NN cord-010119-t1x9gknd 6079 3 control control NN cord-010119-t1x9gknd 6079 4 ( ( -LRB- cord-010119-t1x9gknd 6079 5 FITC FITC NNP cord-010119-t1x9gknd 6079 6 - - HYPH cord-010119-t1x9gknd 6079 7 mouse mouse NN cord-010119-t1x9gknd 6079 8 IgG IgG NNP cord-010119-t1x9gknd 6079 9 ) ) -RRB- cord-010119-t1x9gknd 6079 10 was be VBD cord-010119-t1x9gknd 6079 11 also also RB cord-010119-t1x9gknd 6079 12 analyzed analyze VBN cord-010119-t1x9gknd 6079 13 to to TO cord-010119-t1x9gknd 6079 14 calculate calculate VB cord-010119-t1x9gknd 6079 15 a a DT cord-010119-t1x9gknd 6079 16 reference reference NN cord-010119-t1x9gknd 6079 17 range range NN cord-010119-t1x9gknd 6079 18 of of IN cord-010119-t1x9gknd 6079 19 CD36-nagtive cd36-nagtive CD cord-010119-t1x9gknd 6079 20 phenotype phenotype NN cord-010119-t1x9gknd 6079 21 . . . cord-010119-t1x9gknd 6080 1 For for IN cord-010119-t1x9gknd 6080 2 those those DT cord-010119-t1x9gknd 6080 3 donors donor NNS cord-010119-t1x9gknd 6080 4 with with IN cord-010119-t1x9gknd 6080 5 CD36-negative cd36-negative CD cord-010119-t1x9gknd 6080 6 platelets platelet NNS cord-010119-t1x9gknd 6080 7 , , , cord-010119-t1x9gknd 6080 8 CD36 CD36 NNP cord-010119-t1x9gknd 6080 9 antigen antigen NN cord-010119-t1x9gknd 6080 10 expression expression NN cord-010119-t1x9gknd 6080 11 on on IN cord-010119-t1x9gknd 6080 12 monocytes monocyte NNS cord-010119-t1x9gknd 6080 13 was be VBD cord-010119-t1x9gknd 6080 14 analyzed analyze VBN cord-010119-t1x9gknd 6080 15 further further RB cord-010119-t1x9gknd 6080 16 to to TO cord-010119-t1x9gknd 6080 17 distinguish distinguish VB cord-010119-t1x9gknd 6080 18 between between IN cord-010119-t1x9gknd 6080 19 CD36 CD36 NNP cord-010119-t1x9gknd 6080 20 type type NN cord-010119-t1x9gknd 6080 21 I -PRON- PRP cord-010119-t1x9gknd 6080 22 and and CC cord-010119-t1x9gknd 6080 23 type type NN cord-010119-t1x9gknd 6080 24 II ii CD cord-010119-t1x9gknd 6080 25 deficiency deficiency NN cord-010119-t1x9gknd 6080 26 . . . cord-010119-t1x9gknd 6081 1 Flow flow VB cord-010119-t1x9gknd 6081 2 cytometric cytometric NN cord-010119-t1x9gknd 6081 3 parameters parameter NNS cord-010119-t1x9gknd 6081 4 were be VBD cord-010119-t1x9gknd 6081 5 statistically statistically RB cord-010119-t1x9gknd 6081 6 analyzed analyze VBN cord-010119-t1x9gknd 6081 7 by by IN cord-010119-t1x9gknd 6081 8 Mann Mann NNP cord-010119-t1x9gknd 6081 9 - - HYPH cord-010119-t1x9gknd 6081 10 Whitney Whitney NNP cord-010119-t1x9gknd 6081 11 test test NN cord-010119-t1x9gknd 6081 12 . . . cord-010119-t1x9gknd 6082 1 The the DT cord-010119-t1x9gknd 6082 2 work work NN cord-010119-t1x9gknd 6082 3 was be VBD cord-010119-t1x9gknd 6082 4 supported support VBN cord-010119-t1x9gknd 6082 5 by by IN cord-010119-t1x9gknd 6082 6 National National NNP cord-010119-t1x9gknd 6082 7 Natural Natural NNP cord-010119-t1x9gknd 6082 8 Science Science NNP cord-010119-t1x9gknd 6082 9 Foundation Foundation NNP cord-010119-t1x9gknd 6082 10 of of IN cord-010119-t1x9gknd 6082 11 China China NNP cord-010119-t1x9gknd 6082 12 ( ( -LRB- cord-010119-t1x9gknd 6082 13 81570170 81570170 CD cord-010119-t1x9gknd 6082 14 ) ) -RRB- cord-010119-t1x9gknd 6082 15 and and CC cord-010119-t1x9gknd 6082 16 Zhejiang Zhejiang NNP cord-010119-t1x9gknd 6082 17 High High NNP cord-010119-t1x9gknd 6082 18 - - HYPH cord-010119-t1x9gknd 6082 19 Level Level NNP cord-010119-t1x9gknd 6082 20 Innovative Innovative NNP cord-010119-t1x9gknd 6082 21 Health Health NNP cord-010119-t1x9gknd 6082 22 Talents Talents NNPS cord-010119-t1x9gknd 6082 23 . . . cord-010119-t1x9gknd 6083 1 Results/ Results/ . cord-010119-t1x9gknd 6084 1 Findings finding NNS cord-010119-t1x9gknd 6084 2 : : : cord-010119-t1x9gknd 6085 1 The the DT cord-010119-t1x9gknd 6085 2 MFI MFI NNP cord-010119-t1x9gknd 6085 3 ( ( -LRB- cord-010119-t1x9gknd 6085 4 mean mean VB cord-010119-t1x9gknd 6085 5 fluorescence fluorescence NN cord-010119-t1x9gknd 6085 6 intensity intensity NN cord-010119-t1x9gknd 6085 7 ) ) -RRB- cord-010119-t1x9gknd 6085 8 of of IN cord-010119-t1x9gknd 6085 9 platelet platelet NN cord-010119-t1x9gknd 6085 10 CD36 CD36 NNP cord-010119-t1x9gknd 6085 11 in in IN cord-010119-t1x9gknd 6085 12 all all DT cord-010119-t1x9gknd 6085 13 1282 1282 CD cord-010119-t1x9gknd 6085 14 samples sample NNS cord-010119-t1x9gknd 6085 15 showed show VBD cord-010119-t1x9gknd 6085 16 a a DT cord-010119-t1x9gknd 6085 17 continuous continuous JJ cord-010119-t1x9gknd 6085 18 distribution distribution NN cord-010119-t1x9gknd 6085 19 profile profile NN cord-010119-t1x9gknd 6085 20 , , , cord-010119-t1x9gknd 6085 21 and and CC cord-010119-t1x9gknd 6085 22 no no DT cord-010119-t1x9gknd 6085 23 obvious obvious JJ cord-010119-t1x9gknd 6085 24 fluorescence fluorescence NN cord-010119-t1x9gknd 6085 25 - - HYPH cord-010119-t1x9gknd 6085 26 gap gap NN cord-010119-t1x9gknd 6085 27 could could MD cord-010119-t1x9gknd 6085 28 be be VB cord-010119-t1x9gknd 6085 29 utilized utilize VBN cord-010119-t1x9gknd 6085 30 to to TO cord-010119-t1x9gknd 6085 31 distinguish distinguish VB cord-010119-t1x9gknd 6085 32 negative negative JJ cord-010119-t1x9gknd 6085 33 from from IN cord-010119-t1x9gknd 6085 34 positive positive JJ cord-010119-t1x9gknd 6085 35 phenotype phenotype NN cord-010119-t1x9gknd 6085 36 . . . cord-010119-t1x9gknd 6086 1 On on IN cord-010119-t1x9gknd 6086 2 account account NN cord-010119-t1x9gknd 6086 3 of of IN cord-010119-t1x9gknd 6086 4 this this DT cord-010119-t1x9gknd 6086 5 limitation limitation NN cord-010119-t1x9gknd 6086 6 , , , cord-010119-t1x9gknd 6086 7 we -PRON- PRP cord-010119-t1x9gknd 6086 8 classified classify VBD cord-010119-t1x9gknd 6086 9 the the DT cord-010119-t1x9gknd 6086 10 CD36 CD36 NNP cord-010119-t1x9gknd 6086 11 phenotypes phenotype NNS cord-010119-t1x9gknd 6086 12 using use VBG cord-010119-t1x9gknd 6086 13 the the DT cord-010119-t1x9gknd 6086 14 ( ( -LRB- cord-010119-t1x9gknd 6086 15 mean mean NN cord-010119-t1x9gknd 6086 16 1 1 CD cord-010119-t1x9gknd 6086 17 3SD 3sd CD cord-010119-t1x9gknd 6086 18 ) ) -RRB- cord-010119-t1x9gknd 6086 19 of of IN cord-010119-t1x9gknd 6086 20 the the DT cord-010119-t1x9gknd 6086 21 background background NN cord-010119-t1x9gknd 6086 22 MFI MFI NNP cord-010119-t1x9gknd 6086 23 observed observe VBD cord-010119-t1x9gknd 6086 24 in in IN cord-010119-t1x9gknd 6086 25 isotype isotype NN cord-010119-t1x9gknd 6086 26 controls control NNS cord-010119-t1x9gknd 6086 27 . . . cord-010119-t1x9gknd 6087 1 Forty forty CD cord-010119-t1x9gknd 6087 2 - - HYPH cord-010119-t1x9gknd 6087 3 three three CD cord-010119-t1x9gknd 6087 4 samples sample NNS cord-010119-t1x9gknd 6087 5 were be VBD cord-010119-t1x9gknd 6087 6 detected detect VBN cord-010119-t1x9gknd 6087 7 as as IN cord-010119-t1x9gknd 6087 8 CD36 CD36 NNP cord-010119-t1x9gknd 6087 9 deficiency deficiency NN cord-010119-t1x9gknd 6087 10 on on IN cord-010119-t1x9gknd 6087 11 platelet platelet NN cord-010119-t1x9gknd 6087 12 , , , cord-010119-t1x9gknd 6087 13 in in IN cord-010119-t1x9gknd 6087 14 which which WDT cord-010119-t1x9gknd 6087 15 one one CD cord-010119-t1x9gknd 6087 16 sample sample NN cord-010119-t1x9gknd 6087 17 was be VBD cord-010119-t1x9gknd 6087 18 CD36 CD36 NNP cord-010119-t1x9gknd 6087 19 negative negative JJ cord-010119-t1x9gknd 6087 20 both both DT cord-010119-t1x9gknd 6087 21 on on IN cord-010119-t1x9gknd 6087 22 platelet platelet NN cord-010119-t1x9gknd 6087 23 and and CC cord-010119-t1x9gknd 6087 24 monocyte monocyte NNP cord-010119-t1x9gknd 6087 25 . . . cord-010119-t1x9gknd 6088 1 The the DT cord-010119-t1x9gknd 6088 2 frequency frequency NN cord-010119-t1x9gknd 6088 3 of of IN cord-010119-t1x9gknd 6088 4 CD36 CD36 NNP cord-010119-t1x9gknd 6088 5 type type NN cord-010119-t1x9gknd 6088 6 I -PRON- PRP cord-010119-t1x9gknd 6088 7 and and CC cord-010119-t1x9gknd 6088 8 type type NN cord-010119-t1x9gknd 6088 9 II ii CD cord-010119-t1x9gknd 6088 10 deficiency deficiency NN cord-010119-t1x9gknd 6088 11 in in IN cord-010119-t1x9gknd 6088 12 the the DT cord-010119-t1x9gknd 6088 13 Eastern eastern JJ cord-010119-t1x9gknd 6088 14 Chinese chinese JJ cord-010119-t1x9gknd 6088 15 donors donor NNS cord-010119-t1x9gknd 6088 16 was be VBD cord-010119-t1x9gknd 6088 17 0.08 0.08 CD cord-010119-t1x9gknd 6088 18 % % NN cord-010119-t1x9gknd 6088 19 and and CC cord-010119-t1x9gknd 6088 20 3.3 3.3 CD cord-010119-t1x9gknd 6088 21 % % NN cord-010119-t1x9gknd 6088 22 , , , cord-010119-t1x9gknd 6088 23 respectively respectively RB cord-010119-t1x9gknd 6088 24 . . . cord-010119-t1x9gknd 6089 1 The the DT cord-010119-t1x9gknd 6089 2 average average JJ cord-010119-t1x9gknd 6089 3 MFI MFI NNP cord-010119-t1x9gknd 6089 4 of of IN cord-010119-t1x9gknd 6089 5 CD36 CD36 NNP cord-010119-t1x9gknd 6089 6 deficiency deficiency NN cord-010119-t1x9gknd 6089 7 samples sample NNS cord-010119-t1x9gknd 6089 8 was be VBD cord-010119-t1x9gknd 6089 9 significantly significantly RB cord-010119-t1x9gknd 6089 10 lower low JJR cord-010119-t1x9gknd 6089 11 than than IN cord-010119-t1x9gknd 6089 12 CD36 CD36 NNP cord-010119-t1x9gknd 6089 13 positive positive JJ cord-010119-t1x9gknd 6089 14 samples sample NNS cord-010119-t1x9gknd 6089 15 ( ( -LRB- cord-010119-t1x9gknd 6089 16 15.2 15.2 CD cord-010119-t1x9gknd 6089 17 6 6 CD cord-010119-t1x9gknd 6089 18 7.9 7.9 CD cord-010119-t1x9gknd 6089 19 vs vs IN cord-010119-t1x9gknd 6089 20 79.8 79.8 CD cord-010119-t1x9gknd 6089 21 6 6 CD cord-010119-t1x9gknd 6089 22 37.8 37.8 CD cord-010119-t1x9gknd 6089 23 , , , cord-010119-t1x9gknd 6089 24 P p NN cord-010119-t1x9gknd 6089 25 < < XX cord-010119-t1x9gknd 6089 26 0.0001 0.0001 CD cord-010119-t1x9gknd 6089 27 ) ) -RRB- cord-010119-t1x9gknd 6089 28 . . . cord-010119-t1x9gknd 6090 1 Conclusion conclusion NN cord-010119-t1x9gknd 6090 2 : : : cord-010119-t1x9gknd 6091 1 The the DT cord-010119-t1x9gknd 6091 2 frequency frequency NN cord-010119-t1x9gknd 6091 3 of of IN cord-010119-t1x9gknd 6091 4 platelet platelet NN cord-010119-t1x9gknd 6091 5 CD36 CD36 NNP cord-010119-t1x9gknd 6091 6 deficiency deficiency NN cord-010119-t1x9gknd 6091 7 in in IN cord-010119-t1x9gknd 6091 8 the the DT cord-010119-t1x9gknd 6091 9 Eastern eastern JJ cord-010119-t1x9gknd 6091 10 Chinese chinese JJ cord-010119-t1x9gknd 6091 11 donors donor NNS cord-010119-t1x9gknd 6091 12 was be VBD cord-010119-t1x9gknd 6091 13 close close JJ cord-010119-t1x9gknd 6091 14 to to IN cord-010119-t1x9gknd 6091 15 Japanese japanese JJ cord-010119-t1x9gknd 6091 16 and and CC cord-010119-t1x9gknd 6091 17 African african JJ cord-010119-t1x9gknd 6091 18 Americans Americans NNPS cord-010119-t1x9gknd 6091 19 . . . cord-010119-t1x9gknd 6092 1 It -PRON- PRP cord-010119-t1x9gknd 6092 2 means mean VBZ cord-010119-t1x9gknd 6092 3 that that IN cord-010119-t1x9gknd 6092 4 the the DT cord-010119-t1x9gknd 6092 5 possibility possibility NN cord-010119-t1x9gknd 6092 6 of of IN cord-010119-t1x9gknd 6092 7 CD36 CD36 NNP cord-010119-t1x9gknd 6092 8 antibody antibody NN cord-010119-t1x9gknd 6092 9 occurred occur VBD cord-010119-t1x9gknd 6092 10 by by IN cord-010119-t1x9gknd 6092 11 pregnancy pregnancy NN cord-010119-t1x9gknd 6092 12 and and CC cord-010119-t1x9gknd 6092 13 transfusion transfusion NN cord-010119-t1x9gknd 6092 14 in in IN cord-010119-t1x9gknd 6092 15 this this DT cord-010119-t1x9gknd 6092 16 population population NN cord-010119-t1x9gknd 6092 17 is be VBZ cord-010119-t1x9gknd 6092 18 existed exist VBN cord-010119-t1x9gknd 6092 19 . . . cord-010119-t1x9gknd 6093 1 It -PRON- PRP cord-010119-t1x9gknd 6093 2 is be VBZ cord-010119-t1x9gknd 6093 3 useful useful JJ cord-010119-t1x9gknd 6093 4 to to TO cord-010119-t1x9gknd 6093 5 find find VB cord-010119-t1x9gknd 6093 6 and and CC cord-010119-t1x9gknd 6093 7 register register VB cord-010119-t1x9gknd 6093 8 CD36-deficient cd36-deficient CD cord-010119-t1x9gknd 6093 9 donors donor NNS cord-010119-t1x9gknd 6093 10 by by IN cord-010119-t1x9gknd 6093 11 large large JJ cord-010119-t1x9gknd 6093 12 - - HYPH cord-010119-t1x9gknd 6093 13 samples sample NNS cord-010119-t1x9gknd 6093 14 screening screening NN cord-010119-t1x9gknd 6093 15 for for IN cord-010119-t1x9gknd 6093 16 potential potential JJ cord-010119-t1x9gknd 6093 17 immune immune JJ cord-010119-t1x9gknd 6093 18 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 6093 19 patients patient NNS cord-010119-t1x9gknd 6093 20 with with IN cord-010119-t1x9gknd 6093 21 CD36 CD36 NNP cord-010119-t1x9gknd 6093 22 antibody antibody NN cord-010119-t1x9gknd 6093 23 . . . cord-010119-t1x9gknd 6093 24 _SP cord-010119-t1x9gknd 6094 1 Background Background NNP cord-010119-t1x9gknd 6094 2 / / SYM cord-010119-t1x9gknd 6094 3 Case Case NNP cord-010119-t1x9gknd 6094 4 Studies Studies NNPS cord-010119-t1x9gknd 6094 5 : : : cord-010119-t1x9gknd 6094 6 CD36 CD36 NNP cord-010119-t1x9gknd 6094 7 ( ( -LRB- cord-010119-t1x9gknd 6094 8 GPIV GPIV NNP cord-010119-t1x9gknd 6094 9 , , , cord-010119-t1x9gknd 6094 10 chromosome chromosome NN cord-010119-t1x9gknd 6094 11 7q11.2 7q11.2 CD cord-010119-t1x9gknd 6094 12 ) ) -RRB- cord-010119-t1x9gknd 6094 13 is be VBZ cord-010119-t1x9gknd 6094 14 an an DT cord-010119-t1x9gknd 6094 15 88 88 CD cord-010119-t1x9gknd 6094 16 kDa kDa NNS cord-010119-t1x9gknd 6094 17 glycoprotein glycoprotein NN cord-010119-t1x9gknd 6094 18 expressed express VBN cord-010119-t1x9gknd 6094 19 on on IN cord-010119-t1x9gknd 6094 20 multiple multiple JJ cord-010119-t1x9gknd 6094 21 cell cell NN cord-010119-t1x9gknd 6094 22 types type NNS cord-010119-t1x9gknd 6094 23 including include VBG cord-010119-t1x9gknd 6094 24 platelets platelet NNS cord-010119-t1x9gknd 6094 25 ( ( -LRB- cord-010119-t1x9gknd 6094 26 PLTs PLTs NNP cord-010119-t1x9gknd 6094 27 ) ) -RRB- cord-010119-t1x9gknd 6094 28 , , , cord-010119-t1x9gknd 6094 29 monocytes monocyte NNS cord-010119-t1x9gknd 6094 30 ( ( -LRB- cord-010119-t1x9gknd 6094 31 MONO MONO NNP cord-010119-t1x9gknd 6094 32 ) ) -RRB- cord-010119-t1x9gknd 6094 33 , , , cord-010119-t1x9gknd 6094 34 & & CC cord-010119-t1x9gknd 6094 35 erythroblasts erythroblast NNS cord-010119-t1x9gknd 6094 36 . . . cord-010119-t1x9gknd 6095 1 Although although IN cord-010119-t1x9gknd 6095 2 rare rare JJ cord-010119-t1x9gknd 6095 3 among among IN cord-010119-t1x9gknd 6095 4 whites white NNS cord-010119-t1x9gknd 6095 5 , , , cord-010119-t1x9gknd 6095 6 CD36 CD36 NNP cord-010119-t1x9gknd 6095 7 deficiency deficiency NN cord-010119-t1x9gknd 6095 8 ( ( -LRB- cord-010119-t1x9gknd 6095 9 CD36-n CD36-n NNP cord-010119-t1x9gknd 6095 10 ) ) -RRB- cord-010119-t1x9gknd 6095 11 is be VBZ cord-010119-t1x9gknd 6095 12 observed observe VBN cord-010119-t1x9gknd 6095 13 in in IN cord-010119-t1x9gknd 6095 14 3 3 CD cord-010119-t1x9gknd 6095 15 - - SYM cord-010119-t1x9gknd 6095 16 10 10 CD cord-010119-t1x9gknd 6095 17 % % NN cord-010119-t1x9gknd 6095 18 of of IN cord-010119-t1x9gknd 6095 19 Africans Africans NNPS cord-010119-t1x9gknd 6095 20 ( ( -LRB- cord-010119-t1x9gknd 6095 21 T1264 T1264 NNP cord-010119-t1x9gknd 6095 22 G G NNP cord-010119-t1x9gknd 6095 23 ) ) -RRB- cord-010119-t1x9gknd 6095 24 & & CC cord-010119-t1x9gknd 6095 25 is be VBZ cord-010119-t1x9gknd 6095 26 classified classify VBN cord-010119-t1x9gknd 6095 27 as as IN cord-010119-t1x9gknd 6095 28 either either DT cord-010119-t1x9gknd 6095 29 type type NN cord-010119-t1x9gknd 6095 30 I -PRON- PRP cord-010119-t1x9gknd 6095 31 ( ( -LRB- cord-010119-t1x9gknd 6095 32 CD36-n CD36-n NNP cord-010119-t1x9gknd 6095 33 PLT PLT NNP cord-010119-t1x9gknd 6095 34 , , , cord-010119-t1x9gknd 6095 35 CD36-n CD36-n NNP cord-010119-t1x9gknd 6095 36 MONO MONO NNP cord-010119-t1x9gknd 6095 37 ) ) -RRB- cord-010119-t1x9gknd 6095 38 or or CC cord-010119-t1x9gknd 6095 39 type type NN cord-010119-t1x9gknd 6095 40 II II NNP cord-010119-t1x9gknd 6095 41 ( ( -LRB- cord-010119-t1x9gknd 6095 42 CD36-n CD36-n NNP cord-010119-t1x9gknd 6095 43 PLT PLT NNP cord-010119-t1x9gknd 6095 44 , , , cord-010119-t1x9gknd 6095 45 CD361 CD361 NNP cord-010119-t1x9gknd 6095 46 MONO MONO NNP cord-010119-t1x9gknd 6095 47 ) ) -RRB- cord-010119-t1x9gknd 6095 48 . . . cord-010119-t1x9gknd 6096 1 An an DT cord-010119-t1x9gknd 6096 2 acquired acquire VBN cord-010119-t1x9gknd 6096 3 type type NN cord-010119-t1x9gknd 6096 4 II II NNP cord-010119-t1x9gknd 6096 5 CD36-n CD36-n NNS cord-010119-t1x9gknd 6096 6 phenotype phenotype NN cord-010119-t1x9gknd 6096 7 can can MD cord-010119-t1x9gknd 6096 8 also also RB cord-010119-t1x9gknd 6096 9 be be VB cord-010119-t1x9gknd 6096 10 observed observe VBN cord-010119-t1x9gknd 6096 11 in in IN cord-010119-t1x9gknd 6096 12 the the DT cord-010119-t1x9gknd 6096 13 setting setting NN cord-010119-t1x9gknd 6096 14 of of IN cord-010119-t1x9gknd 6096 15 myelodysplastic myelodysplastic JJ cord-010119-t1x9gknd 6096 16 syndrome syndrome NN cord-010119-t1x9gknd 6096 17 ( ( -LRB- cord-010119-t1x9gknd 6096 18 MDS MDS NNP cord-010119-t1x9gknd 6096 19 ) ) -RRB- cord-010119-t1x9gknd 6096 20 . . . cord-010119-t1x9gknd 6097 1 Type type NN cord-010119-t1x9gknd 6097 2 1 1 CD cord-010119-t1x9gknd 6097 3 CD36-n CD36-n NNS cord-010119-t1x9gknd 6097 4 individuals individual NNS cord-010119-t1x9gknd 6097 5 can can MD cord-010119-t1x9gknd 6097 6 develop develop VB cord-010119-t1x9gknd 6097 7 anti anti JJ cord-010119-t1x9gknd 6097 8 - - JJ cord-010119-t1x9gknd 6097 9 CD36 cd36 JJ cord-010119-t1x9gknd 6097 10 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6097 11 with with IN cord-010119-t1x9gknd 6097 12 PLT PLT NNP cord-010119-t1x9gknd 6097 13 refractoriness refractoriness NNP cord-010119-t1x9gknd 6097 14 & & CC cord-010119-t1x9gknd 6097 15 neonatal neonatal JJ cord-010119-t1x9gknd 6097 16 alloimmune alloimmune NNP cord-010119-t1x9gknd 6097 17 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 6097 18 . . . cord-010119-t1x9gknd 6098 1 We -PRON- PRP cord-010119-t1x9gknd 6098 2 report report VBP cord-010119-t1x9gknd 6098 3 a a DT cord-010119-t1x9gknd 6098 4 case case NN cord-010119-t1x9gknd 6098 5 of of IN cord-010119-t1x9gknd 6098 6 profound profound JJ cord-010119-t1x9gknd 6098 7 PLT PLT NNP cord-010119-t1x9gknd 6098 8 refractoriness refractoriness NN cord-010119-t1x9gknd 6098 9 caused cause VBN cord-010119-t1x9gknd 6098 10 by by IN cord-010119-t1x9gknd 6098 11 anti anti JJ cord-010119-t1x9gknd 6098 12 - - JJ cord-010119-t1x9gknd 6098 13 CD36 CD36 NNP cord-010119-t1x9gknd 6098 14 in in IN cord-010119-t1x9gknd 6098 15 a a DT cord-010119-t1x9gknd 6098 16 patient patient NN cord-010119-t1x9gknd 6098 17 with with IN cord-010119-t1x9gknd 6098 18 newly newly RB cord-010119-t1x9gknd 6098 19 diagnosed diagnose VBN cord-010119-t1x9gknd 6098 20 MDS MDS NNP cord-010119-t1x9gknd 6098 21 . . . cord-010119-t1x9gknd 6099 1 Study Study NNP cord-010119-t1x9gknd 6099 2 Design Design NNP cord-010119-t1x9gknd 6099 3 / / SYM cord-010119-t1x9gknd 6099 4 Method method NN cord-010119-t1x9gknd 6099 5 : : : cord-010119-t1x9gknd 6100 1 HLA HLA NNP cord-010119-t1x9gknd 6100 2 antibody antibody NN cord-010119-t1x9gknd 6100 3 testing testing NN cord-010119-t1x9gknd 6100 4 was be VBD cord-010119-t1x9gknd 6100 5 performed perform VBN cord-010119-t1x9gknd 6100 6 with with IN cord-010119-t1x9gknd 6100 7 a a DT cord-010119-t1x9gknd 6100 8 commercial commercial JJ cord-010119-t1x9gknd 6100 9 bead bead NN cord-010119-t1x9gknd 6100 10 - - HYPH cord-010119-t1x9gknd 6100 11 based base VBN cord-010119-t1x9gknd 6100 12 fluorescent fluorescent NN cord-010119-t1x9gknd 6100 13 assay assay NN cord-010119-t1x9gknd 6100 14 . . . cord-010119-t1x9gknd 6101 1 CD36 CD36 NNP cord-010119-t1x9gknd 6101 2 phenotyping phenotyping NN cord-010119-t1x9gknd 6101 3 ( ( -LRB- cord-010119-t1x9gknd 6101 4 PLT PLT NNP cord-010119-t1x9gknd 6101 5 , , , cord-010119-t1x9gknd 6101 6 MONO MONO NNP cord-010119-t1x9gknd 6101 7 ) ) -RRB- cord-010119-t1x9gknd 6101 8 of of IN cord-010119-t1x9gknd 6101 9 patient patient NNP cord-010119-t1x9gknd 6101 10 & & CC cord-010119-t1x9gknd 6101 11 family family NN cord-010119-t1x9gknd 6101 12 members member NNS cord-010119-t1x9gknd 6101 13 was be VBD cord-010119-t1x9gknd 6101 14 performed perform VBN cord-010119-t1x9gknd 6101 15 by by IN cord-010119-t1x9gknd 6101 16 flow flow NN cord-010119-t1x9gknd 6101 17 cytometry cytometry NN cord-010119-t1x9gknd 6101 18 ( ( -LRB- cord-010119-t1x9gknd 6101 19 FC FC NNP cord-010119-t1x9gknd 6101 20 ) ) -RRB- cord-010119-t1x9gknd 6101 21 . . . cord-010119-t1x9gknd 6102 1 CD36 CD36 NNP cord-010119-t1x9gknd 6102 2 staining staining NN cord-010119-t1x9gknd 6102 3 of of IN cord-010119-t1x9gknd 6102 4 bone bone NN cord-010119-t1x9gknd 6102 5 marrow marrow NN cord-010119-t1x9gknd 6102 6 was be VBD cord-010119-t1x9gknd 6102 7 performed perform VBN cord-010119-t1x9gknd 6102 8 by by IN cord-010119-t1x9gknd 6102 9 immunohistochemistry immunohistochemistry NN cord-010119-t1x9gknd 6102 10 . . . cord-010119-t1x9gknd 6103 1 PLT PLT NNP cord-010119-t1x9gknd 6103 2 crossmatching crossmatching NNP cord-010119-t1x9gknd 6103 3 ( ( -LRB- cord-010119-t1x9gknd 6103 4 PLT PLT NNP cord-010119-t1x9gknd 6103 5 - - HYPH cord-010119-t1x9gknd 6103 6 XM XM NNP cord-010119-t1x9gknd 6103 7 ) ) -RRB- cord-010119-t1x9gknd 6103 8 was be VBD cord-010119-t1x9gknd 6103 9 performed perform VBN cord-010119-t1x9gknd 6103 10 by by IN cord-010119-t1x9gknd 6103 11 the the DT cord-010119-t1x9gknd 6103 12 American American NNP cord-010119-t1x9gknd 6103 13 Red Red NNP cord-010119-t1x9gknd 6103 14 Cross Cross NNP cord-010119-t1x9gknd 6103 15 . . . cord-010119-t1x9gknd 6104 1 PLTspecific PLTspecific NNP cord-010119-t1x9gknd 6104 2 alloantibody alloantibody NN cord-010119-t1x9gknd 6104 3 testing testing NN cord-010119-t1x9gknd 6104 4 & & CC cord-010119-t1x9gknd 6104 5 CD36 CD36 NNP cord-010119-t1x9gknd 6104 6 DNA DNA NNP cord-010119-t1x9gknd 6104 7 sequencing sequencing NN cord-010119-t1x9gknd 6104 8 were be VBD cord-010119-t1x9gknd 6104 9 performed perform VBN cord-010119-t1x9gknd 6104 10 at at IN cord-010119-t1x9gknd 6104 11 a a DT cord-010119-t1x9gknd 6104 12 commercial commercial JJ cord-010119-t1x9gknd 6104 13 reference reference NN cord-010119-t1x9gknd 6104 14 laboratory laboratory NN cord-010119-t1x9gknd 6104 15 . . . cord-010119-t1x9gknd 6105 1 Results/ Results/ . cord-010119-t1x9gknd 6106 1 Finding find VBG cord-010119-t1x9gknd 6106 2 : : : cord-010119-t1x9gknd 6106 3 The the DT cord-010119-t1x9gknd 6106 4 patient patient NN cord-010119-t1x9gknd 6106 5 was be VBD cord-010119-t1x9gknd 6106 6 an an DT cord-010119-t1x9gknd 6106 7 80 80 CD cord-010119-t1x9gknd 6106 8 year year NN cord-010119-t1x9gknd 6106 9 - - HYPH cord-010119-t1x9gknd 6106 10 old old JJ cord-010119-t1x9gknd 6106 11 , , , cord-010119-t1x9gknd 6106 12 group group NN cord-010119-t1x9gknd 6106 13 O1 o1 NN cord-010119-t1x9gknd 6106 14 African african JJ cord-010119-t1x9gknd 6106 15 - - HYPH cord-010119-t1x9gknd 6106 16 American american JJ cord-010119-t1x9gknd 6106 17 male male NN cord-010119-t1x9gknd 6106 18 who who WP cord-010119-t1x9gknd 6106 19 presented present VBD cord-010119-t1x9gknd 6106 20 with with IN cord-010119-t1x9gknd 6106 21 blurry blurry JJ cord-010119-t1x9gknd 6106 22 vision vision NN cord-010119-t1x9gknd 6106 23 & & CC cord-010119-t1x9gknd 6106 24 lightheadedness lightheadedness NN cord-010119-t1x9gknd 6106 25 . . . cord-010119-t1x9gknd 6107 1 Complete complete JJ cord-010119-t1x9gknd 6107 2 blood blood NN cord-010119-t1x9gknd 6107 3 count count NN cord-010119-t1x9gknd 6107 4 findings finding NNS cord-010119-t1x9gknd 6107 5 were be VBD cord-010119-t1x9gknd 6107 6 significant significant JJ cord-010119-t1x9gknd 6107 7 for for IN cord-010119-t1x9gknd 6107 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 6107 9 4.4 4.4 CD cord-010119-t1x9gknd 6107 10 g g NN cord-010119-t1x9gknd 6107 11 / / SYM cord-010119-t1x9gknd 6107 12 dL dL NNP cord-010119-t1x9gknd 6107 13 & & CC cord-010119-t1x9gknd 6107 14 PLT PLT NNP cord-010119-t1x9gknd 6108 1 count count VB cord-010119-t1x9gknd 6109 1 5K 5K NNP cord-010119-t1x9gknd 6109 2 / / SYM cord-010119-t1x9gknd 6109 3 mL. mL. NNP cord-010119-t1x9gknd 6109 4 Bone Bone NNP cord-010119-t1x9gknd 6109 5 marrow marrow NN cord-010119-t1x9gknd 6109 6 biopsy biopsy NN cord-010119-t1x9gknd 6109 7 & & CC cord-010119-t1x9gknd 6109 8 cytogenetic cytogenetic NNP cord-010119-t1x9gknd 6109 9 analysis analysis NNP cord-010119-t1x9gknd 6109 10 revealed reveal VBD cord-010119-t1x9gknd 6109 11 multilineage multilineage NN cord-010119-t1x9gknd 6109 12 dysplasia dysplasia NN cord-010119-t1x9gknd 6109 13 , , , cord-010119-t1x9gknd 6109 14 5 5 CD cord-010119-t1x9gknd 6109 15 - - SYM cord-010119-t1x9gknd 6109 16 10 10 CD cord-010119-t1x9gknd 6109 17 % % NN cord-010119-t1x9gknd 6109 18 blasts blast NNS cord-010119-t1x9gknd 6109 19 & & CC cord-010119-t1x9gknd 6109 20 a a DT cord-010119-t1x9gknd 6109 21 complex complex JJ cord-010119-t1x9gknd 6109 22 karyotype karyotype NN cord-010119-t1x9gknd 6109 23 with with IN cord-010119-t1x9gknd 6109 24 del(7)(q22q34 del(7)(q22q34 NN cord-010119-t1x9gknd 6109 25 ) ) -RRB- cord-010119-t1x9gknd 6109 26 consistent consistent JJ cord-010119-t1x9gknd 6109 27 with with IN cord-010119-t1x9gknd 6109 28 MDS MDS NNP cord-010119-t1x9gknd 6109 29 . . . cord-010119-t1x9gknd 6110 1 PLT PLT NNP cord-010119-t1x9gknd 6110 2 refractory refractory JJ cord-010119-t1x9gknd 6110 3 work work NN cord-010119-t1x9gknd 6110 4 - - HYPH cord-010119-t1x9gknd 6110 5 up up NN cord-010119-t1x9gknd 6110 6 was be VBD cord-010119-t1x9gknd 6110 7 initiated initiate VBN cord-010119-t1x9gknd 6110 8 after after IN cord-010119-t1x9gknd 6110 9 repeated repeat VBN cord-010119-t1x9gknd 6110 10 PLT PLT NNP cord-010119-t1x9gknd 6110 11 transfusion transfusion NN cord-010119-t1x9gknd 6110 12 failures failure NNS cord-010119-t1x9gknd 6110 13 with with IN cord-010119-t1x9gknd 6110 14 corrected correct VBN cord-010119-t1x9gknd 6110 15 count count NN cord-010119-t1x9gknd 6110 16 increments increment NNS cord-010119-t1x9gknd 6110 17 ( ( -LRB- cord-010119-t1x9gknd 6110 18 CCIs CCIs NNP cord-010119-t1x9gknd 6110 19 ) ) -RRB- cord-010119-t1x9gknd 6110 20 < < XX cord-010119-t1x9gknd 6110 21 5 5 CD cord-010119-t1x9gknd 6110 22 . . . cord-010119-t1x9gknd 6111 1 HLA HLA NNP cord-010119-t1x9gknd 6111 2 antibody antibody NN cord-010119-t1x9gknd 6111 3 testing testing NN cord-010119-t1x9gknd 6111 4 was be VBD cord-010119-t1x9gknd 6111 5 negative negative JJ cord-010119-t1x9gknd 6111 6 ( ( -LRB- cord-010119-t1x9gknd 6111 7 class class NN cord-010119-t1x9gknd 6111 8 I -PRON- PRP cord-010119-t1x9gknd 6111 9 panel panel VBP cord-010119-t1x9gknd 6111 10 reactive reactive JJ cord-010119-t1x9gknd 6111 11 antibody antibody NN cord-010119-t1x9gknd 6111 12 ( ( -LRB- cord-010119-t1x9gknd 6111 13 PRA)50 pra)50 CD cord-010119-t1x9gknd 6111 14 % % NN cord-010119-t1x9gknd 6111 15 ) ) -RRB- cord-010119-t1x9gknd 6111 16 . . . cord-010119-t1x9gknd 6112 1 The the DT cord-010119-t1x9gknd 6112 2 patient patient NN cord-010119-t1x9gknd 6112 3 was be VBD cord-010119-t1x9gknd 6112 4 PLT PLT NNP cord-010119-t1x9gknd 6112 5 - - HYPH cord-010119-t1x9gknd 6112 6 XM XM NNP cord-010119-t1x9gknd 6112 7 - - HYPH cord-010119-t1x9gknd 6112 8 incompatible incompatible JJ cord-010119-t1x9gknd 6112 9 with with IN cord-010119-t1x9gknd 6112 10 most most JJS cord-010119-t1x9gknd 6112 11 donors donor NNS cord-010119-t1x9gknd 6112 12 ( ( -LRB- cord-010119-t1x9gknd 6112 13 10/14 10/14 CD cord-010119-t1x9gknd 6112 14 ) ) -RRB- cord-010119-t1x9gknd 6112 15 . . . cord-010119-t1x9gknd 6113 1 A a DT cord-010119-t1x9gknd 6113 2 trial trial NN cord-010119-t1x9gknd 6113 3 of of IN cord-010119-t1x9gknd 6113 4 4 4 CD cord-010119-t1x9gknd 6113 5 group group NN cord-010119-t1x9gknd 6113 6 O o NN cord-010119-t1x9gknd 6113 7 , , , cord-010119-t1x9gknd 6113 8 PLT PLT NNP cord-010119-t1x9gknd 6113 9 - - HYPH cord-010119-t1x9gknd 6113 10 XM XM NNP cord-010119-t1x9gknd 6113 11 - - HYPH cord-010119-t1x9gknd 6113 12 compatible compatible JJ cord-010119-t1x9gknd 6113 13 PLTs plt NNS cord-010119-t1x9gknd 6113 14 was be VBD cord-010119-t1x9gknd 6113 15 unsuccessful unsuccessful JJ cord-010119-t1x9gknd 6113 16 ( ( -LRB- cord-010119-t1x9gknd 6113 17 CCI CCI NNP cord-010119-t1x9gknd 6113 18 1 1 CD cord-010119-t1x9gknd 6113 19 ) ) -RRB- cord-010119-t1x9gknd 6113 20 . . . cord-010119-t1x9gknd 6114 1 Subsequent subsequent JJ cord-010119-t1x9gknd 6114 2 testing testing NN cord-010119-t1x9gknd 6114 3 for for IN cord-010119-t1x9gknd 6114 4 PLT PLT NNP cord-010119-t1x9gknd 6114 5 - - HYPH cord-010119-t1x9gknd 6114 6 specific specific JJ cord-010119-t1x9gknd 6114 7 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6114 8 identified identify VBD cord-010119-t1x9gknd 6114 9 anti anti JJ cord-010119-t1x9gknd 6114 10 - - JJ cord-010119-t1x9gknd 6114 11 CD36 CD36 NNP cord-010119-t1x9gknd 6114 12 . . . cord-010119-t1x9gknd 6115 1 FC FC NNP cord-010119-t1x9gknd 6115 2 - - HYPH cord-010119-t1x9gknd 6115 3 phenotyping phenotyping NN cord-010119-t1x9gknd 6115 4 showed show VBD cord-010119-t1x9gknd 6115 5 no no DT cord-010119-t1x9gknd 6115 6 CD36 CD36 NNP cord-010119-t1x9gknd 6115 7 on on IN cord-010119-t1x9gknd 6115 8 patient patient NN cord-010119-t1x9gknd 6115 9 's 's POS cord-010119-t1x9gknd 6115 10 MONO mono NN cord-010119-t1x9gknd 6115 11 or or CC cord-010119-t1x9gknd 6115 12 PLT PLT NNP cord-010119-t1x9gknd 6115 13 , , , cord-010119-t1x9gknd 6115 14 consistent consistent JJ cord-010119-t1x9gknd 6115 15 with with IN cord-010119-t1x9gknd 6115 16 type type NN cord-010119-t1x9gknd 6115 17 I -PRON- PRP cord-010119-t1x9gknd 6115 18 CD36-n cd36-n VBP cord-010119-t1x9gknd 6115 19 . . . cord-010119-t1x9gknd 6116 1 Preliminary preliminary JJ cord-010119-t1x9gknd 6116 2 DNA DNA NNP cord-010119-t1x9gknd 6116 3 results result NNS cord-010119-t1x9gknd 6116 4 show show VBP cord-010119-t1x9gknd 6116 5 that that IN cord-010119-t1x9gknd 6116 6 the the DT cord-010119-t1x9gknd 6116 7 patient patient NN cord-010119-t1x9gknd 6116 8 is be VBZ cord-010119-t1x9gknd 6116 9 heterozygous heterozygous JJ cord-010119-t1x9gknd 6116 10 for for IN cord-010119-t1x9gknd 6116 11 T1264G. T1264G. NNP cord-010119-t1x9gknd 6116 12 Because because IN cord-010119-t1x9gknd 6116 13 CD36-n CD36-n NNP cord-010119-t1x9gknd 6116 14 apheresis apheresis NN cord-010119-t1x9gknd 6116 15 PLT PLT NNP cord-010119-t1x9gknd 6116 16 were be VBD cord-010119-t1x9gknd 6116 17 unavailable unavailable JJ cord-010119-t1x9gknd 6116 18 from from IN cord-010119-t1x9gknd 6116 19 blood blood NN cord-010119-t1x9gknd 6116 20 suppliers supplier NNS cord-010119-t1x9gknd 6116 21 , , , cord-010119-t1x9gknd 6116 22 the the DT cord-010119-t1x9gknd 6116 23 patient patient NN cord-010119-t1x9gknd 6116 24 's 's POS cord-010119-t1x9gknd 6116 25 3 3 CD cord-010119-t1x9gknd 6116 26 children child NNS cord-010119-t1x9gknd 6116 27 & & CC cord-010119-t1x9gknd 6116 28 grandson grandson NN cord-010119-t1x9gknd 6116 29 were be VBD cord-010119-t1x9gknd 6116 30 screened screen VBN cord-010119-t1x9gknd 6116 31 as as IN cord-010119-t1x9gknd 6116 32 possible possible JJ cord-010119-t1x9gknd 6116 33 donors donor NNS cord-010119-t1x9gknd 6116 34 : : : cord-010119-t1x9gknd 6116 35 All all DT cord-010119-t1x9gknd 6116 36 showed show VBD cord-010119-t1x9gknd 6116 37 normal normal JJ cord-010119-t1x9gknd 6116 38 CD36 CD36 NNP cord-010119-t1x9gknd 6116 39 expression expression NN cord-010119-t1x9gknd 6116 40 on on IN cord-010119-t1x9gknd 6116 41 PLTs plt NNS cord-010119-t1x9gknd 6116 42 . . . cord-010119-t1x9gknd 6117 1 Trial trial NN cord-010119-t1x9gknd 6117 2 of of IN cord-010119-t1x9gknd 6117 3 eltrombopag eltrombopag NNP cord-010119-t1x9gknd 6117 4 & & CC cord-010119-t1x9gknd 6117 5 romiplostim romiplostim NNP cord-010119-t1x9gknd 6117 6 was be VBD cord-010119-t1x9gknd 6117 7 attempted attempt VBN cord-010119-t1x9gknd 6117 8 with with IN cord-010119-t1x9gknd 6117 9 no no DT cord-010119-t1x9gknd 6117 10 improvement improvement NN cord-010119-t1x9gknd 6117 11 in in IN cord-010119-t1x9gknd 6117 12 PLT PLT NNP cord-010119-t1x9gknd 6117 13 count count NN cord-010119-t1x9gknd 6117 14 . . . cord-010119-t1x9gknd 6118 1 Repeat repeat VB cord-010119-t1x9gknd 6118 2 HLA HLA NNP cord-010119-t1x9gknd 6118 3 antibody antibody NN cord-010119-t1x9gknd 6118 4 testing testing NN cord-010119-t1x9gknd 6118 5 ( ( -LRB- cord-010119-t1x9gknd 6118 6 day day NN cord-010119-t1x9gknd 6118 7 16 16 CD cord-010119-t1x9gknd 6118 8 ) ) -RRB- cord-010119-t1x9gknd 6118 9 demonstrated demonstrate VBD cord-010119-t1x9gknd 6118 10 new new JJ cord-010119-t1x9gknd 6118 11 class class NN cord-010119-t1x9gknd 6119 1 I -PRON- PRP cord-010119-t1x9gknd 6119 2 alloantibodies alloantibodie VBZ cord-010119-t1x9gknd 6120 1 ( ( -LRB- cord-010119-t1x9gknd 6120 2 PRA PRA NNP cord-010119-t1x9gknd 6120 3 5 5 CD cord-010119-t1x9gknd 6120 4 55 55 CD cord-010119-t1x9gknd 6120 5 % % NN cord-010119-t1x9gknd 6120 6 ) ) -RRB- cord-010119-t1x9gknd 6120 7 in in IN cord-010119-t1x9gknd 6120 8 response response NN cord-010119-t1x9gknd 6120 9 to to IN cord-010119-t1x9gknd 6120 10 transfusion transfusion NN cord-010119-t1x9gknd 6120 11 ( ( -LRB- cord-010119-t1x9gknd 6120 12 21 21 CD cord-010119-t1x9gknd 6120 13 apheresis apheresis NN cord-010119-t1x9gknd 6120 14 PLTs plt NNS cord-010119-t1x9gknd 6120 15 , , , cord-010119-t1x9gknd 6120 16 5 5 CD cord-010119-t1x9gknd 6120 17 RBCs rbc NNS cord-010119-t1x9gknd 6120 18 ) ) -RRB- cord-010119-t1x9gknd 6120 19 . . . cord-010119-t1x9gknd 6121 1 Given give VBN cord-010119-t1x9gknd 6121 2 his -PRON- PRP$ cord-010119-t1x9gknd 6121 3 PLT PLT NNP cord-010119-t1x9gknd 6121 4 refractoriness refractoriness NNP cord-010119-t1x9gknd 6121 5 & & CC cord-010119-t1x9gknd 6121 6 poor poor JJ cord-010119-t1x9gknd 6121 7 prognosis prognosis NN cord-010119-t1x9gknd 6121 8 , , , cord-010119-t1x9gknd 6121 9 the the DT cord-010119-t1x9gknd 6121 10 patient patient NN cord-010119-t1x9gknd 6121 11 opted opt VBD cord-010119-t1x9gknd 6121 12 for for IN cord-010119-t1x9gknd 6121 13 hospice hospice NN cord-010119-t1x9gknd 6121 14 . . . cord-010119-t1x9gknd 6122 1 Conclusion conclusion NN cord-010119-t1x9gknd 6122 2 : : : cord-010119-t1x9gknd 6122 3 We -PRON- PRP cord-010119-t1x9gknd 6122 4 describe describe VBP cord-010119-t1x9gknd 6122 5 a a DT cord-010119-t1x9gknd 6122 6 patient patient NN cord-010119-t1x9gknd 6122 7 with with IN cord-010119-t1x9gknd 6122 8 CD36-n CD36-n NNP cord-010119-t1x9gknd 6122 9 & & CC cord-010119-t1x9gknd 6122 10 severe severe JJ cord-010119-t1x9gknd 6122 11 PLT PLT NNP cord-010119-t1x9gknd 6122 12 refractoriness refractorines VBZ cord-010119-t1x9gknd 6122 13 in in IN cord-010119-t1x9gknd 6122 14 the the DT cord-010119-t1x9gknd 6122 15 setting setting NN cord-010119-t1x9gknd 6122 16 of of IN cord-010119-t1x9gknd 6122 17 new new JJ cord-010119-t1x9gknd 6122 18 MDS MDS NNP cord-010119-t1x9gknd 6122 19 , , , cord-010119-t1x9gknd 6122 20 and and CC cord-010119-t1x9gknd 6122 21 7q 7q CD cord-010119-t1x9gknd 6122 22 - - HYPH cord-010119-t1x9gknd 6122 23 chromosomal chromosomal JJ cord-010119-t1x9gknd 6122 24 abnormalities abnormality NNS cord-010119-t1x9gknd 6122 25 . . . cord-010119-t1x9gknd 6123 1 The the DT cord-010119-t1x9gknd 6123 2 absence absence NN cord-010119-t1x9gknd 6123 3 of of IN cord-010119-t1x9gknd 6123 4 CD36 CD36 NNP cord-010119-t1x9gknd 6123 5 on on IN cord-010119-t1x9gknd 6123 6 PLT PLT NNP cord-010119-t1x9gknd 6123 7 & & CC cord-010119-t1x9gknd 6123 8 MONO MONO NNP cord-010119-t1x9gknd 6123 9 support support NN cord-010119-t1x9gknd 6123 10 congenital congenital JJ cord-010119-t1x9gknd 6123 11 type type NN cord-010119-t1x9gknd 6123 12 1 1 CD cord-010119-t1x9gknd 6123 13 CD36-n CD36-n NNS cord-010119-t1x9gknd 6123 14 although although IN cord-010119-t1x9gknd 6123 15 a a DT cord-010119-t1x9gknd 6123 16 contribution contribution NN cord-010119-t1x9gknd 6123 17 by by IN cord-010119-t1x9gknd 6123 18 the the DT cord-010119-t1x9gknd 6123 19 patient patient NN cord-010119-t1x9gknd 6123 20 's 's POS cord-010119-t1x9gknd 6123 21 underlying underlie VBG cord-010119-t1x9gknd 6123 22 MDS MDS NNP cord-010119-t1x9gknd 6123 23 can can MD cord-010119-t1x9gknd 6123 24 not not RB cord-010119-t1x9gknd 6123 25 be be VB cord-010119-t1x9gknd 6123 26 excluded exclude VBN cord-010119-t1x9gknd 6123 27 . . . cord-010119-t1x9gknd 6124 1 Rapid Rapid NNP cord-010119-t1x9gknd 6124 2 Platelet Platelet NNP cord-010119-t1x9gknd 6124 3 Donor Donor NNP cord-010119-t1x9gknd 6124 4 Classification Classification NNP cord-010119-t1x9gknd 6124 5 : : : cord-010119-t1x9gknd 6124 6 HLA HLA NNP cord-010119-t1x9gknd 6124 7 & & CC cord-010119-t1x9gknd 6124 8 HPA HPA NNP cord-010119-t1x9gknd 6124 9 Profiles Profiles NNPS cord-010119-t1x9gknd 6124 10 By by IN cord-010119-t1x9gknd 6124 11 " " `` cord-010119-t1x9gknd 6124 12 Leansequencing leansequencing NN cord-010119-t1x9gknd 6124 13 " " '' cord-010119-t1x9gknd 6124 14 without without IN cord-010119-t1x9gknd 6124 15 DNA DNA NNP cord-010119-t1x9gknd 6124 16 Purification Purification NNP cord-010119-t1x9gknd 6124 17 Dipika Dipika NNP cord-010119-t1x9gknd 6124 18 Patel Patel NNP cord-010119-t1x9gknd 6124 19 1 1 CD cord-010119-t1x9gknd 6124 20 , , , cord-010119-t1x9gknd 6124 21 Kristopher Kristopher NNP cord-010119-t1x9gknd 6124 22 Fernandez Fernandez NNP cord-010119-t1x9gknd 6124 23 * * NFP cord-010119-t1x9gknd 6124 24 1 1 CD cord-010119-t1x9gknd 6124 25 , , , cord-010119-t1x9gknd 6124 26 Eric Eric NNP cord-010119-t1x9gknd 6124 27 Senaldi Senaldi NNP cord-010119-t1x9gknd 6124 28 2 2 CD cord-010119-t1x9gknd 6124 29 , , , cord-010119-t1x9gknd 6124 30 Pascal Pascal NNP cord-010119-t1x9gknd 6124 31 George George NNP cord-010119-t1x9gknd 6124 32 2 2 CD cord-010119-t1x9gknd 6124 33 , , , cord-010119-t1x9gknd 6124 34 Michael Michael NNP cord-010119-t1x9gknd 6124 35 Seul Seul NNP cord-010119-t1x9gknd 6124 36 1 1 CD cord-010119-t1x9gknd 6124 37 and and CC cord-010119-t1x9gknd 6124 38 Ghazala Ghazala NNP cord-010119-t1x9gknd 6124 39 Hashmi Hashmi NNP cord-010119-t1x9gknd 6124 40 1 1 CD cord-010119-t1x9gknd 6124 41 . . . cord-010119-t1x9gknd 6125 1 1 1 CD cord-010119-t1x9gknd 6125 2 BioMolecular BioMolecular NNP cord-010119-t1x9gknd 6125 3 Analytics Analytics NNP cord-010119-t1x9gknd 6125 4 , , , cord-010119-t1x9gknd 6125 5 2 2 CD cord-010119-t1x9gknd 6125 6 Central Central NNP cord-010119-t1x9gknd 6125 7 Jersey Jersey NNP cord-010119-t1x9gknd 6125 8 Blood Blood NNP cord-010119-t1x9gknd 6125 9 Center Center NNP cord-010119-t1x9gknd 6125 10 Background Background NNP cord-010119-t1x9gknd 6125 11 / / SYM cord-010119-t1x9gknd 6125 12 Case Case NNP cord-010119-t1x9gknd 6125 13 Studies Studies NNPS cord-010119-t1x9gknd 6125 14 : : : cord-010119-t1x9gknd 6126 1 Prophylactic prophylactic JJ cord-010119-t1x9gknd 6126 2 platelet platelet NN cord-010119-t1x9gknd 6126 3 transfusion transfusion NN cord-010119-t1x9gknd 6126 4 is be VBZ cord-010119-t1x9gknd 6126 5 the the DT cord-010119-t1x9gknd 6126 6 standard standard NN cord-010119-t1x9gknd 6126 7 of of IN cord-010119-t1x9gknd 6126 8 care care NN cord-010119-t1x9gknd 6126 9 for for IN cord-010119-t1x9gknd 6126 10 managing manage VBG cord-010119-t1x9gknd 6126 11 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 6126 12 . . . cord-010119-t1x9gknd 6127 1 In in IN cord-010119-t1x9gknd 6127 2 the the DT cord-010119-t1x9gknd 6127 3 emerging emerge VBG cord-010119-t1x9gknd 6127 4 paradigm paradigm NN cord-010119-t1x9gknd 6127 5 of of IN cord-010119-t1x9gknd 6127 6 personalized personalized JJ cord-010119-t1x9gknd 6127 7 medicine medicine NN cord-010119-t1x9gknd 6127 8 , , , cord-010119-t1x9gknd 6127 9 the the DT cord-010119-t1x9gknd 6127 10 selection selection NN cord-010119-t1x9gknd 6127 11 of of IN cord-010119-t1x9gknd 6127 12 cellular cellular JJ cord-010119-t1x9gknd 6127 13 products product NNS cord-010119-t1x9gknd 6127 14 in in IN cord-010119-t1x9gknd 6127 15 accordance accordance NN cord-010119-t1x9gknd 6127 16 with with IN cord-010119-t1x9gknd 6127 17 patient patient JJ cord-010119-t1x9gknd 6127 18 immunomolecular immunomolecular JJ cord-010119-t1x9gknd 6127 19 signatures signature NNS cord-010119-t1x9gknd 6127 20 has have VBZ cord-010119-t1x9gknd 6127 21 the the DT cord-010119-t1x9gknd 6127 22 potential potential NN cord-010119-t1x9gknd 6127 23 to to TO cord-010119-t1x9gknd 6127 24 reduce reduce VB cord-010119-t1x9gknd 6127 25 the the DT cord-010119-t1x9gknd 6127 26 rate rate NN cord-010119-t1x9gknd 6127 27 of of IN cord-010119-t1x9gknd 6127 28 antibody antibody NN cord-010119-t1x9gknd 6127 29 - - HYPH cord-010119-t1x9gknd 6127 30 mediated mediate VBN cord-010119-t1x9gknd 6127 31 platelet platelet NN cord-010119-t1x9gknd 6127 32 clearance clearance NN cord-010119-t1x9gknd 6127 33 and and CC cord-010119-t1x9gknd 6127 34 thus thus RB cord-010119-t1x9gknd 6127 35 to to TO cord-010119-t1x9gknd 6127 36 improve improve VB cord-010119-t1x9gknd 6127 37 treatment treatment NN cord-010119-t1x9gknd 6127 38 efficacy efficacy NN cord-010119-t1x9gknd 6127 39 . . . cord-010119-t1x9gknd 6128 1 While while IN cord-010119-t1x9gknd 6128 2 the the DT cord-010119-t1x9gknd 6128 3 benefits benefit NNS cord-010119-t1x9gknd 6128 4 of of IN cord-010119-t1x9gknd 6128 5 customizing customize VBG cord-010119-t1x9gknd 6128 6 transfusion transfusion NN cord-010119-t1x9gknd 6128 7 therapy therapy NN cord-010119-t1x9gknd 6128 8 have have VBP cord-010119-t1x9gknd 6128 9 long long RB cord-010119-t1x9gknd 6128 10 been be VBN cord-010119-t1x9gknd 6128 11 recognized recognize VBN cord-010119-t1x9gknd 6128 12 ( ( -LRB- cord-010119-t1x9gknd 6128 13 Gmur1978 Gmur1978 NNP cord-010119-t1x9gknd 6128 14 http://bit.ly/2q51heq http://bit.ly/2q51heq NNP cord-010119-t1x9gknd 6128 15 ) ) -RRB- cord-010119-t1x9gknd 6128 16 , , , cord-010119-t1x9gknd 6128 17 the the DT cord-010119-t1x9gknd 6128 18 routine routine JJ cord-010119-t1x9gknd 6128 19 , , , cord-010119-t1x9gknd 6128 20 real real JJ cord-010119-t1x9gknd 6128 21 - - HYPH cord-010119-t1x9gknd 6128 22 time time NN cord-010119-t1x9gknd 6128 23 selection selection NN cord-010119-t1x9gknd 6128 24 of of IN cord-010119-t1x9gknd 6128 25 platelets platelet NNS cord-010119-t1x9gknd 6128 26 by by IN cord-010119-t1x9gknd 6128 27 immunogenetic immunogenetic JJ cord-010119-t1x9gknd 6128 28 profile profile NNP cord-010119-t1x9gknd 6128 29 has have VBZ cord-010119-t1x9gknd 6128 30 remained remain VBN cord-010119-t1x9gknd 6128 31 impractical impractical JJ cord-010119-t1x9gknd 6128 32 by by IN cord-010119-t1x9gknd 6128 33 current current JJ cord-010119-t1x9gknd 6128 34 methods method NNS cord-010119-t1x9gknd 6128 35 of of IN cord-010119-t1x9gknd 6128 36 DNA dna NN cord-010119-t1x9gknd 6128 37 analysis analysis NN cord-010119-t1x9gknd 6128 38 . . . cord-010119-t1x9gknd 6129 1 To to TO cord-010119-t1x9gknd 6129 2 address address VB cord-010119-t1x9gknd 6129 3 this this DT cord-010119-t1x9gknd 6129 4 issue issue NN cord-010119-t1x9gknd 6129 5 , , , cord-010119-t1x9gknd 6129 6 we -PRON- PRP cord-010119-t1x9gknd 6129 7 evaluated evaluate VBD cord-010119-t1x9gknd 6129 8 a a DT cord-010119-t1x9gknd 6129 9 process process NN cord-010119-t1x9gknd 6129 10 of of IN cord-010119-t1x9gknd 6129 11 platelet platelet NN cord-010119-t1x9gknd 6129 12 donor donor NN cord-010119-t1x9gknd 6129 13 classification classification NN cord-010119-t1x9gknd 6129 14 using use VBG cord-010119-t1x9gknd 6129 15 buccal buccal JJ cord-010119-t1x9gknd 6129 16 swab swab NN cord-010119-t1x9gknd 6129 17 samples sample NNS cord-010119-t1x9gknd 6129 18 from from IN cord-010119-t1x9gknd 6129 19 apheresis apheresis NN cord-010119-t1x9gknd 6129 20 platelet platelet NN cord-010119-t1x9gknd 6129 21 donors donor NNS cord-010119-t1x9gknd 6129 22 for for IN cord-010119-t1x9gknd 6129 23 determining determine VBG cord-010119-t1x9gknd 6129 24 the the DT cord-010119-t1x9gknd 6129 25 combined combine VBN cord-010119-t1x9gknd 6129 26 HLA HLA NNP cord-010119-t1x9gknd 6129 27 class class NN cord-010119-t1x9gknd 6129 28 I i NN cord-010119-t1x9gknd 6129 29 and and CC cord-010119-t1x9gknd 6129 30 HPA HPA NNP cord-010119-t1x9gknd 6129 31 signature signature NN cord-010119-t1x9gknd 6129 32 without without IN cord-010119-t1x9gknd 6129 33 DNA dna NN cord-010119-t1x9gknd 6129 34 purification purification NN cord-010119-t1x9gknd 6129 35 using use VBG cord-010119-t1x9gknd 6129 36 a a DT cord-010119-t1x9gknd 6129 37 novel novel NN cord-010119-t1x9gknd 6129 38 " " `` cord-010119-t1x9gknd 6129 39 LeanSequencing LeanSequencing NNP cord-010119-t1x9gknd 6129 40 " " '' cord-010119-t1x9gknd 6129 41 process process NN cord-010119-t1x9gknd 6129 42 . . . cord-010119-t1x9gknd 6130 1 Study Study NNP cord-010119-t1x9gknd 6130 2 Design Design NNP cord-010119-t1x9gknd 6130 3 / / SYM cord-010119-t1x9gknd 6130 4 Method method NN cord-010119-t1x9gknd 6130 5 : : : cord-010119-t1x9gknd 6131 1 Under under IN cord-010119-t1x9gknd 6131 2 a a DT cord-010119-t1x9gknd 6131 3 study study NN cord-010119-t1x9gknd 6131 4 protocol protocol NN cord-010119-t1x9gknd 6131 5 and and CC cord-010119-t1x9gknd 6131 6 informed informed JJ cord-010119-t1x9gknd 6131 7 consent consent NN cord-010119-t1x9gknd 6131 8 , , , cord-010119-t1x9gknd 6131 9 we -PRON- PRP cord-010119-t1x9gknd 6131 10 evaluated evaluate VBD cord-010119-t1x9gknd 6131 11 a a DT cord-010119-t1x9gknd 6131 12 process process NN cord-010119-t1x9gknd 6131 13 for for IN cord-010119-t1x9gknd 6131 14 collecting collect VBG cord-010119-t1x9gknd 6131 15 and and CC cord-010119-t1x9gknd 6131 16 classifying classify VBG cord-010119-t1x9gknd 6131 17 buccal buccal JJ cord-010119-t1x9gknd 6131 18 swab swab NN cord-010119-t1x9gknd 6131 19 samples sample NNS cord-010119-t1x9gknd 6131 20 from from IN cord-010119-t1x9gknd 6131 21 $ $ $ cord-010119-t1x9gknd 6131 22 100 100 CD cord-010119-t1x9gknd 6131 23 adult adult NN cord-010119-t1x9gknd 6131 24 donors donor NNS cord-010119-t1x9gknd 6131 25 who who WP cord-010119-t1x9gknd 6131 26 had have VBD cord-010119-t1x9gknd 6131 27 made make VBN cord-010119-t1x9gknd 6131 28 ! ! . cord-010119-t1x9gknd 6132 1 6 6 CD cord-010119-t1x9gknd 6132 2 donations donation NNS cord-010119-t1x9gknd 6132 3 in in IN cord-010119-t1x9gknd 6132 4 the the DT cord-010119-t1x9gknd 6132 5 previous previous JJ cord-010119-t1x9gknd 6132 6 12 12 CD cord-010119-t1x9gknd 6132 7 months month NNS cord-010119-t1x9gknd 6132 8 . . . cord-010119-t1x9gknd 6133 1 Samples sample NNS cord-010119-t1x9gknd 6133 2 ( ( -LRB- cord-010119-t1x9gknd 6133 3 labeled label VBN cord-010119-t1x9gknd 6133 4 with with IN cord-010119-t1x9gknd 6133 5 study study NN cord-010119-t1x9gknd 6133 6 barcodes barcode NNS cord-010119-t1x9gknd 6133 7 ) ) -RRB- cord-010119-t1x9gknd 6133 8 were be VBD cord-010119-t1x9gknd 6133 9 shipped ship VBN cord-010119-t1x9gknd 6133 10 weekly weekly RB cord-010119-t1x9gknd 6133 11 to to IN cord-010119-t1x9gknd 6133 12 BioMolecular BioMolecular NNP cord-010119-t1x9gknd 6133 13 Analytics Analytics NNP cord-010119-t1x9gknd 6133 14 ( ( -LRB- cord-010119-t1x9gknd 6133 15 " " `` cord-010119-t1x9gknd 6133 16 bmx bmx NNP cord-010119-t1x9gknd 6133 17 " " '' cord-010119-t1x9gknd 6133 18 ) ) -RRB- cord-010119-t1x9gknd 6133 19 for for IN cord-010119-t1x9gknd 6133 20 preparation preparation NN cord-010119-t1x9gknd 6133 21 of of IN cord-010119-t1x9gknd 6133 22 " " `` cord-010119-t1x9gknd 6133 23 crude crude JJ cord-010119-t1x9gknd 6133 24 extracts extract NNS cord-010119-t1x9gknd 6133 25 " " '' cord-010119-t1x9gknd 6133 26 for for IN cord-010119-t1x9gknd 6133 27 LeanSequencing LeanSequencing NNP cord-010119-t1x9gknd 6134 1 : : : cord-010119-t1x9gknd 6134 2 this this DT cord-010119-t1x9gknd 6134 3 novel novel NN cord-010119-t1x9gknd 6134 4 process process NN cord-010119-t1x9gknd 6134 5 combines combine VBZ cord-010119-t1x9gknd 6134 6 a a DT cord-010119-t1x9gknd 6134 7 proprietary proprietary JJ cord-010119-t1x9gknd 6134 8 sample sample NN cord-010119-t1x9gknd 6134 9 pooling pooling NN cord-010119-t1x9gknd 6134 10 strategy strategy NN cord-010119-t1x9gknd 6134 11 with with IN cord-010119-t1x9gknd 6134 12 a a DT cord-010119-t1x9gknd 6134 13 protocol protocol NN cord-010119-t1x9gknd 6134 14 that that WDT cord-010119-t1x9gknd 6134 15 eliminates eliminate VBZ cord-010119-t1x9gknd 6134 16 many many JJ cord-010119-t1x9gknd 6134 17 traditional traditional JJ cord-010119-t1x9gknd 6134 18 sample sample NN cord-010119-t1x9gknd 6134 19 " " `` cord-010119-t1x9gknd 6134 20 clean clean JJ cord-010119-t1x9gknd 6134 21 - - HYPH cord-010119-t1x9gknd 6134 22 up up RP cord-010119-t1x9gknd 6134 23 " " '' cord-010119-t1x9gknd 6134 24 steps step NNS cord-010119-t1x9gknd 6134 25 . . . cord-010119-t1x9gknd 6135 1 Briefly briefly RB cord-010119-t1x9gknd 6135 2 , , , cord-010119-t1x9gknd 6135 3 after after IN cord-010119-t1x9gknd 6135 4 preparation preparation NN cord-010119-t1x9gknd 6135 5 of of IN cord-010119-t1x9gknd 6135 6 crude crude JJ cord-010119-t1x9gknd 6135 7 extracts extract NNS cord-010119-t1x9gknd 6135 8 , , , cord-010119-t1x9gknd 6135 9 samples sample NNS cord-010119-t1x9gknd 6135 10 were be VBD cord-010119-t1x9gknd 6135 11 amplified amplify VBN cord-010119-t1x9gknd 6135 12 , , , cord-010119-t1x9gknd 6135 13 pooled pool VBN cord-010119-t1x9gknd 6135 14 and and CC cord-010119-t1x9gknd 6135 15 analyzed analyze VBN cord-010119-t1x9gknd 6135 16 ( ( -LRB- cord-010119-t1x9gknd 6135 17 in in IN cord-010119-t1x9gknd 6135 18 separate separate JJ cord-010119-t1x9gknd 6135 19 runs run NNS cord-010119-t1x9gknd 6135 20 ) ) -RRB- cord-010119-t1x9gknd 6135 21 for for IN cord-010119-t1x9gknd 6135 22 2 2 CD cord-010119-t1x9gknd 6135 23 , , , cord-010119-t1x9gknd 6135 24 3 3 CD cord-010119-t1x9gknd 6135 25 , , , cord-010119-t1x9gknd 6135 26 4 4 CD cord-010119-t1x9gknd 6135 27 , , , cord-010119-t1x9gknd 6135 28 5 5 CD cord-010119-t1x9gknd 6135 29 , , , cord-010119-t1x9gknd 6135 30 6 6 CD cord-010119-t1x9gknd 6135 31 , , , cord-010119-t1x9gknd 6135 32 7 7 CD cord-010119-t1x9gknd 6135 33 , , , cord-010119-t1x9gknd 6135 34 8 8 CD cord-010119-t1x9gknd 6135 35 , , , cord-010119-t1x9gknd 6135 36 9 9 CD cord-010119-t1x9gknd 6135 37 , , , cord-010119-t1x9gknd 6135 38 11 11 CD cord-010119-t1x9gknd 6135 39 , , , cord-010119-t1x9gknd 6135 40 15 15 CD cord-010119-t1x9gknd 6135 41 and and CC cord-010119-t1x9gknd 6135 42 for for IN cord-010119-t1x9gknd 6135 43 HLA HLA NNP cord-010119-t1x9gknd 6135 44 Class Class NNP cord-010119-t1x9gknd 6135 45 1 1 CD cord-010119-t1x9gknd 6135 46 ( ( -LRB- cord-010119-t1x9gknd 6135 47 A A NNP cord-010119-t1x9gknd 6135 48 , , , cord-010119-t1x9gknd 6135 49 B b NN cord-010119-t1x9gknd 6135 50 , , , cord-010119-t1x9gknd 6135 51 C C NNP cord-010119-t1x9gknd 6135 52 ) ) -RRB- cord-010119-t1x9gknd 6135 53 , , , cord-010119-t1x9gknd 6135 54 the the DT cord-010119-t1x9gknd 6135 55 latter latter JJ cord-010119-t1x9gknd 6135 56 using use VBG cord-010119-t1x9gknd 6135 57 a a DT cord-010119-t1x9gknd 6135 58 proprietary proprietary JJ cord-010119-t1x9gknd 6135 59 design design NN cord-010119-t1x9gknd 6135 60 that that WDT cord-010119-t1x9gknd 6135 61 limits limit VBZ cord-010119-t1x9gknd 6135 62 analysis analysis NN cord-010119-t1x9gknd 6135 63 to to IN cord-010119-t1x9gknd 6135 64 informative informative JJ cord-010119-t1x9gknd 6135 65 alleles allele NNS cord-010119-t1x9gknd 6135 66 in in IN cord-010119-t1x9gknd 6135 67 the the DT cord-010119-t1x9gknd 6135 68 HLA HLA NNP cord-010119-t1x9gknd 6135 69 sequence sequence NN cord-010119-t1x9gknd 6135 70 ; ; : cord-010119-t1x9gknd 6135 71 this this DT cord-010119-t1x9gknd 6135 72 " " `` cord-010119-t1x9gknd 6135 73 information information NN cord-010119-t1x9gknd 6135 74 - - HYPH cord-010119-t1x9gknd 6135 75 theoretic theoretic JJ cord-010119-t1x9gknd 6135 76 " " '' cord-010119-t1x9gknd 6135 77 design design NN cord-010119-t1x9gknd 6135 78 permits permit VBZ cord-010119-t1x9gknd 6135 79 direct direct JJ cord-010119-t1x9gknd 6135 80 allele allele NN cord-010119-t1x9gknd 6135 81 and and CC cord-010119-t1x9gknd 6135 82 haplotype haplotype NN cord-010119-t1x9gknd 6135 83 reconstruction reconstruction NN cord-010119-t1x9gknd 6135 84 using use VBG cord-010119-t1x9gknd 6135 85 bmx bmx NN cord-010119-t1x9gknd 6135 86 - - HYPH cord-010119-t1x9gknd 6135 87 proprietary proprietary JJ cord-010119-t1x9gknd 6135 88 software software NN cord-010119-t1x9gknd 6135 89 . . . cord-010119-t1x9gknd 6136 1 A a DT cord-010119-t1x9gknd 6136 2 subset subset NN cord-010119-t1x9gknd 6136 3 of of IN cord-010119-t1x9gknd 6136 4 crude crude JJ cord-010119-t1x9gknd 6136 5 extracts extract NNS cord-010119-t1x9gknd 6136 6 was be VBD cord-010119-t1x9gknd 6136 7 purified purify VBN cord-010119-t1x9gknd 6136 8 and and CC cord-010119-t1x9gknd 6136 9 analyzed analyze VBN cord-010119-t1x9gknd 6136 10 side side NN cord-010119-t1x9gknd 6136 11 by by IN cord-010119-t1x9gknd 6136 12 side side NN cord-010119-t1x9gknd 6136 13 with with IN cord-010119-t1x9gknd 6136 14 positive positive JJ cord-010119-t1x9gknd 6136 15 and and CC cord-010119-t1x9gknd 6136 16 negative negative JJ cord-010119-t1x9gknd 6136 17 controls control NNS cord-010119-t1x9gknd 6136 18 . . . cord-010119-t1x9gknd 6137 1 Results result NNS cord-010119-t1x9gknd 6137 2 / / SYM cord-010119-t1x9gknd 6137 3 Finding finding NN cord-010119-t1x9gknd 6137 4 : : : cord-010119-t1x9gknd 6138 1 Crude crude JJ cord-010119-t1x9gknd 6138 2 extracts extract NNS cord-010119-t1x9gknd 6138 3 from from IN cord-010119-t1x9gknd 6138 4 buccal buccal JJ cord-010119-t1x9gknd 6138 5 swabs swab NNS cord-010119-t1x9gknd 6138 6 produced produce VBD cord-010119-t1x9gknd 6138 7 viable viable JJ cord-010119-t1x9gknd 6138 8 profiles profile NNS cord-010119-t1x9gknd 6138 9 for for IN cord-010119-t1x9gknd 6138 10 HPA HPA NNP cord-010119-t1x9gknd 6138 11 as as RB cord-010119-t1x9gknd 6138 12 well well RB cord-010119-t1x9gknd 6138 13 as as IN cord-010119-t1x9gknd 6139 1 HLA HLA NNP cord-010119-t1x9gknd 6139 2 class class NN cord-010119-t1x9gknd 6139 3 I -PRON- PRP cord-010119-t1x9gknd 6139 4 with with IN cord-010119-t1x9gknd 6139 5 significant significant JJ cord-010119-t1x9gknd 6139 6 savings saving NNS cord-010119-t1x9gknd 6139 7 in in IN cord-010119-t1x9gknd 6139 8 time time NN cord-010119-t1x9gknd 6139 9 - - HYPH cord-010119-t1x9gknd 6139 10 to to IN cord-010119-t1x9gknd 6139 11 - - HYPH cord-010119-t1x9gknd 6139 12 result result NN cord-010119-t1x9gknd 6139 13 . . . cord-010119-t1x9gknd 6140 1 As as IN cord-010119-t1x9gknd 6140 2 an an DT cord-010119-t1x9gknd 6140 3 illustration illustration NN cord-010119-t1x9gknd 6140 4 , , , cord-010119-t1x9gknd 6140 5 the the DT cord-010119-t1x9gknd 6140 6 table table NN cord-010119-t1x9gknd 6140 7 reports report VBZ cord-010119-t1x9gknd 6140 8 allele allele NN cord-010119-t1x9gknd 6140 9 frequencies frequency NNS cord-010119-t1x9gknd 6140 10 for for IN cord-010119-t1x9gknd 6140 11 platelet platelet NN cord-010119-t1x9gknd 6140 12 - - HYPH cord-010119-t1x9gknd 6140 13 antigens antigen NNS cord-010119-t1x9gknd 6140 14 ( ( -LRB- cord-010119-t1x9gknd 6140 15 " " `` cord-010119-t1x9gknd 6140 16 HPA HPA NNP cord-010119-t1x9gknd 6140 17 " " '' cord-010119-t1x9gknd 6140 18 ) ) -RRB- cord-010119-t1x9gknd 6140 19 that that WDT cord-010119-t1x9gknd 6140 20 are be VBP cord-010119-t1x9gknd 6140 21 consistent consistent JJ cord-010119-t1x9gknd 6140 22 with with IN cord-010119-t1x9gknd 6140 23 a a DT cord-010119-t1x9gknd 6140 24 predominantly predominantly RB cord-010119-t1x9gknd 6140 25 Caucasian caucasian JJ cord-010119-t1x9gknd 6140 26 or or CC cord-010119-t1x9gknd 6140 27 Hispanic hispanic JJ cord-010119-t1x9gknd 6140 28 platelet platelet NN cord-010119-t1x9gknd 6140 29 donor donor NN cord-010119-t1x9gknd 6140 30 population population NN cord-010119-t1x9gknd 6140 31 ( ( -LRB- cord-010119-t1x9gknd 6140 32 http://bit.ly/2pDplF8 http://bit.ly/2pDplF8 NFP cord-010119-t1x9gknd 6140 33 ) ) -RRB- cord-010119-t1x9gknd 6140 34 in in IN cord-010119-t1x9gknd 6140 35 HW HW NNP cord-010119-t1x9gknd 6140 36 equilibrium equilibrium NN cord-010119-t1x9gknd 6140 37 . . . cord-010119-t1x9gknd 6141 1 Similarly similarly RB cord-010119-t1x9gknd 6141 2 , , , cord-010119-t1x9gknd 6141 3 HLA HLA NNP cord-010119-t1x9gknd 6141 4 - - HYPH cord-010119-t1x9gknd 6141 5 class class NN cord-010119-t1x9gknd 6141 6 I -PRON- PRP cord-010119-t1x9gknd 6141 7 haplotype haplotype NN cord-010119-t1x9gknd 6141 8 frequencies frequency NNS cord-010119-t1x9gknd 6141 9 were be VBD cord-010119-t1x9gknd 6141 10 determined determine VBN cord-010119-t1x9gknd 6141 11 . . . cord-010119-t1x9gknd 6142 1 Conclusion conclusion NN cord-010119-t1x9gknd 6142 2 : : : cord-010119-t1x9gknd 6143 1 LeanSequencing LeanSequencing NNP cord-010119-t1x9gknd 6143 2 lends lend VBZ cord-010119-t1x9gknd 6143 3 itself -PRON- PRP cord-010119-t1x9gknd 6143 4 to to IN cord-010119-t1x9gknd 6143 5 the the DT cord-010119-t1x9gknd 6143 6 rapid rapid JJ cord-010119-t1x9gknd 6143 7 determination determination NN cord-010119-t1x9gknd 6143 8 of of IN cord-010119-t1x9gknd 6143 9 HLA HLA NNP cord-010119-t1x9gknd 6143 10 - - HYPH cord-010119-t1x9gknd 6143 11 class class NN cord-010119-t1x9gknd 6143 12 I I NNP cord-010119-t1x9gknd 6143 13 and and CC cord-010119-t1x9gknd 6143 14 HPA HPA NNP cord-010119-t1x9gknd 6143 15 signatures signature NNS cord-010119-t1x9gknd 6143 16 of of IN cord-010119-t1x9gknd 6143 17 platelets platelet NNS cord-010119-t1x9gknd 6143 18 ; ; : cord-010119-t1x9gknd 6143 19 the the DT cord-010119-t1x9gknd 6143 20 process process NN cord-010119-t1x9gknd 6143 21 with with IN cord-010119-t1x9gknd 6143 22 its -PRON- PRP$ cord-010119-t1x9gknd 6143 23 streamlined streamlined JJ cord-010119-t1x9gknd 6143 24 lean lean JJ cord-010119-t1x9gknd 6143 25 protocol protocol NN cord-010119-t1x9gknd 6143 26 achieves achieve VBZ cord-010119-t1x9gknd 6143 27 additional additional JJ cord-010119-t1x9gknd 6143 28 time time NN cord-010119-t1x9gknd 6143 29 ( ( -LRB- cord-010119-t1x9gknd 6143 30 and and CC cord-010119-t1x9gknd 6143 31 cost cost NN cord-010119-t1x9gknd 6143 32 ) ) -RRB- cord-010119-t1x9gknd 6143 33 savings saving NNS cord-010119-t1x9gknd 6143 34 by by IN cord-010119-t1x9gknd 6143 35 accommodating accommodate VBG cord-010119-t1x9gknd 6143 36 crude crude JJ cord-010119-t1x9gknd 6143 37 extracts extract NNS cord-010119-t1x9gknd 6143 38 produced produce VBN cord-010119-t1x9gknd 6143 39 from from IN cord-010119-t1x9gknd 6143 40 buccal buccal JJ cord-010119-t1x9gknd 6143 41 swab swab NN cord-010119-t1x9gknd 6143 42 samples sample NNS cord-010119-t1x9gknd 6143 43 collected collect VBN cord-010119-t1x9gknd 6143 44 and and CC cord-010119-t1x9gknd 6143 45 handled handle VBN cord-010119-t1x9gknd 6143 46 in in IN cord-010119-t1x9gknd 6143 47 accordance accordance NN cord-010119-t1x9gknd 6143 48 with with IN cord-010119-t1x9gknd 6143 49 the the DT cord-010119-t1x9gknd 6143 50 process process NN cord-010119-t1x9gknd 6143 51 validated validate VBN cord-010119-t1x9gknd 6143 52 in in IN cord-010119-t1x9gknd 6143 53 this this DT cord-010119-t1x9gknd 6143 54 project project NN cord-010119-t1x9gknd 6143 55 . . . cord-010119-t1x9gknd 6144 1 The the DT cord-010119-t1x9gknd 6144 2 process process NN cord-010119-t1x9gknd 6144 3 could could MD cord-010119-t1x9gknd 6144 4 be be VB cord-010119-t1x9gknd 6144 5 readily readily RB cord-010119-t1x9gknd 6144 6 implemented implement VBN cord-010119-t1x9gknd 6144 7 to to IN cord-010119-t1x9gknd 6144 8 another another DT cord-010119-t1x9gknd 6144 9 site site NN cord-010119-t1x9gknd 6144 10 using use VBG cord-010119-t1x9gknd 6144 11 the the DT cord-010119-t1x9gknd 6144 12 elements element NNS cord-010119-t1x9gknd 6144 13 and and CC cord-010119-t1x9gknd 6144 14 process process NN cord-010119-t1x9gknd 6144 15 developed develop VBN cord-010119-t1x9gknd 6144 16 . . . cord-010119-t1x9gknd 6145 1 The the DT cord-010119-t1x9gknd 6145 2 " " `` cord-010119-t1x9gknd 6145 3 Pool Pool NNP cord-010119-t1x9gknd 6145 4 & & CC cord-010119-t1x9gknd 6145 5 Plex Plex NNP cord-010119-t1x9gknd 6145 6 " " '' cord-010119-t1x9gknd 6145 7 process process NN cord-010119-t1x9gknd 6145 8 and and CC cord-010119-t1x9gknd 6145 9 the the DT cord-010119-t1x9gknd 6145 10 early early JJ cord-010119-t1x9gknd 6145 11 donor donor NN cord-010119-t1x9gknd 6145 12 recruitment recruitment NN cord-010119-t1x9gknd 6145 13 enables enable VBZ cord-010119-t1x9gknd 6145 14 economies economy NNS cord-010119-t1x9gknd 6145 15 of of IN cord-010119-t1x9gknd 6145 16 scale scale NN cord-010119-t1x9gknd 6145 17 for for IN cord-010119-t1x9gknd 6145 18 matched matched JJ cord-010119-t1x9gknd 6145 19 donor donor NN cord-010119-t1x9gknd 6145 20 procurement procurement NN cord-010119-t1x9gknd 6145 21 . . . cord-010119-t1x9gknd 6146 1 The the DT cord-010119-t1x9gknd 6146 2 Serological Serological NNP cord-010119-t1x9gknd 6146 3 Characteristics Characteristics NNPS cord-010119-t1x9gknd 6146 4 and and CC cord-010119-t1x9gknd 6146 5 Heritage Heritage NNP cord-010119-t1x9gknd 6146 6 Background Background NNP cord-010119-t1x9gknd 6146 7 of of IN cord-010119-t1x9gknd 6146 8 a a DT cord-010119-t1x9gknd 6146 9 Novel Novel NNP cord-010119-t1x9gknd 6146 10 HLA HLA NNP cord-010119-t1x9gknd 6146 11 Allele Allele NNP cord-010119-t1x9gknd 6146 12 , , , cord-010119-t1x9gknd 6146 13 HLA HLA NNP cord-010119-t1x9gknd 6146 14 - - HYPH cord-010119-t1x9gknd 6146 15 a a DT cord-010119-t1x9gknd 6146 16 * * NFP cord-010119-t1x9gknd 6146 17 26:82 26:82 CD cord-010119-t1x9gknd 6146 18 Chuan Chuan NNP cord-010119-t1x9gknd 6146 19 - - HYPH cord-010119-t1x9gknd 6146 20 fu fu NNP cord-010119-t1x9gknd 6146 21 Zhu Zhu NNP cord-010119-t1x9gknd 6146 22 * * NFP cord-010119-t1x9gknd 6146 23 , , , cord-010119-t1x9gknd 6146 24 Yong Yong NNP cord-010119-t1x9gknd 6146 25 - - HYPH cord-010119-t1x9gknd 6146 26 hong hong NNP cord-010119-t1x9gknd 6146 27 Song Song NNP cord-010119-t1x9gknd 6146 28 , , , cord-010119-t1x9gknd 6146 29 Xiang Xiang NNP cord-010119-t1x9gknd 6146 30 - - HYPH cord-010119-t1x9gknd 6146 31 min min NNP cord-010119-t1x9gknd 6146 32 Nie Nie NNP cord-010119-t1x9gknd 6146 33 and and CC cord-010119-t1x9gknd 6146 34 Wen Wen NNP cord-010119-t1x9gknd 6146 35 - - HYPH cord-010119-t1x9gknd 6146 36 ben ben NNP cord-010119-t1x9gknd 6146 37 Qiao Qiao NNP cord-010119-t1x9gknd 6146 38 . . . cord-010119-t1x9gknd 6147 1 Blood blood NN cord-010119-t1x9gknd 6147 2 Center Center NNP cord-010119-t1x9gknd 6147 3 of of IN cord-010119-t1x9gknd 6147 4 Shandong Shandong NNP cord-010119-t1x9gknd 6147 5 Province Province NNP cord-010119-t1x9gknd 6147 6 Background Background NNP cord-010119-t1x9gknd 6147 7 / / SYM cord-010119-t1x9gknd 6147 8 Case Case NNP cord-010119-t1x9gknd 6147 9 Studies Studies NNPS cord-010119-t1x9gknd 6147 10 : : : cord-010119-t1x9gknd 6148 1 There there EX cord-010119-t1x9gknd 6148 2 are be VBP cord-010119-t1x9gknd 6148 3 16,429 16,429 CD cord-010119-t1x9gknd 6148 4 HLA HLA NNP cord-010119-t1x9gknd 6148 5 alleles allele NNS cord-010119-t1x9gknd 6148 6 documented document VBD cord-010119-t1x9gknd 6148 7 according accord VBG cord-010119-t1x9gknd 6148 8 to to IN cord-010119-t1x9gknd 6148 9 the the DT cord-010119-t1x9gknd 6148 10 IMGT IMGT NNP cord-010119-t1x9gknd 6148 11 / / SYM cord-010119-t1x9gknd 6148 12 HLA HLA NNP cord-010119-t1x9gknd 6148 13 Sequence sequence NN cord-010119-t1x9gknd 6148 14 Database Database NNP cord-010119-t1x9gknd 6148 15 in in IN cord-010119-t1x9gknd 6148 16 Janury2017 Janury2017 NNP cord-010119-t1x9gknd 6148 17 , , , cord-010119-t1x9gknd 6148 18 And and CC cord-010119-t1x9gknd 6148 19 more more JJR cord-010119-t1x9gknd 6148 20 than than IN cord-010119-t1x9gknd 6148 21 80 80 CD cord-010119-t1x9gknd 6148 22 % % NN cord-010119-t1x9gknd 6148 23 of of IN cord-010119-t1x9gknd 6148 24 them -PRON- PRP cord-010119-t1x9gknd 6148 25 were be VBD cord-010119-t1x9gknd 6148 26 identified identify VBN cord-010119-t1x9gknd 6148 27 in in IN cord-010119-t1x9gknd 6148 28 the the DT cord-010119-t1x9gknd 6148 29 last last JJ cord-010119-t1x9gknd 6148 30 10 10 CD cord-010119-t1x9gknd 6148 31 years year NNS cord-010119-t1x9gknd 6148 32 . . . cord-010119-t1x9gknd 6149 1 Besides besides IN cord-010119-t1x9gknd 6149 2 sequences sequence NNS cord-010119-t1x9gknd 6149 3 many many JJ cord-010119-t1x9gknd 6149 4 of of IN cord-010119-t1x9gknd 6149 5 the the DT cord-010119-t1x9gknd 6149 6 novel novel JJ cord-010119-t1x9gknd 6149 7 HLA HLA NNP cord-010119-t1x9gknd 6149 8 alleles allele NNS cord-010119-t1x9gknd 6149 9 have have VBP cord-010119-t1x9gknd 6149 10 not not RB cord-010119-t1x9gknd 6149 11 been be VBN cord-010119-t1x9gknd 6149 12 analyzed analyze VBN cord-010119-t1x9gknd 6149 13 their -PRON- PRP$ cord-010119-t1x9gknd 6149 14 serological serological JJ cord-010119-t1x9gknd 6149 15 reactivities reactivity NNS cord-010119-t1x9gknd 6149 16 . . . cord-010119-t1x9gknd 6150 1 HLA HLA NNP cord-010119-t1x9gknd 6150 2 - - HYPH cord-010119-t1x9gknd 6150 3 A A NNP cord-010119-t1x9gknd 6150 4 * * NFP cord-010119-t1x9gknd 6150 5 26:82 26:82 CD cord-010119-t1x9gknd 6150 6 allele allele NN cord-010119-t1x9gknd 6150 7 was be VBD cord-010119-t1x9gknd 6150 8 fist fist NN cord-010119-t1x9gknd 6150 9 detected detect VBN cord-010119-t1x9gknd 6150 10 in in IN cord-010119-t1x9gknd 6150 11 our -PRON- PRP$ cord-010119-t1x9gknd 6150 12 laboratory laboratory NN cord-010119-t1x9gknd 6150 13 during during IN cord-010119-t1x9gknd 6150 14 our -PRON- PRP$ cord-010119-t1x9gknd 6150 15 HLA HLA NNP cord-010119-t1x9gknd 6150 16 typing type VBG cord-010119-t1x9gknd 6150 17 for for IN cord-010119-t1x9gknd 6150 18 China China NNP cord-010119-t1x9gknd 6150 19 Bone Bone NNP cord-010119-t1x9gknd 6150 20 Marrow Marrow NNP cord-010119-t1x9gknd 6150 21 Donor Donor NNP cord-010119-t1x9gknd 6150 22 Program(CMDP Program(CMDP NNP cord-010119-t1x9gknd 6150 23 ) ) -RRB- cord-010119-t1x9gknd 6150 24 . . . cord-010119-t1x9gknd 6151 1 For for IN cord-010119-t1x9gknd 6151 2 further further JJ cord-010119-t1x9gknd 6151 3 study study NN cord-010119-t1x9gknd 6151 4 , , , cord-010119-t1x9gknd 6151 5 the the DT cord-010119-t1x9gknd 6151 6 serological serological JJ cord-010119-t1x9gknd 6151 7 characteristics characteristic NNS cord-010119-t1x9gknd 6151 8 and and CC cord-010119-t1x9gknd 6151 9 heritage heritage NN cord-010119-t1x9gknd 6151 10 investigation investigation NN cord-010119-t1x9gknd 6151 11 were be VBD cord-010119-t1x9gknd 6151 12 performed perform VBN cord-010119-t1x9gknd 6151 13 . . . cord-010119-t1x9gknd 6152 1 Study Study NNP cord-010119-t1x9gknd 6152 2 Design Design NNP cord-010119-t1x9gknd 6152 3 / / SYM cord-010119-t1x9gknd 6152 4 Methods method NNS cord-010119-t1x9gknd 6152 5 : : : cord-010119-t1x9gknd 6153 1 The the DT cord-010119-t1x9gknd 6153 2 routine routine JJ cord-010119-t1x9gknd 6153 3 HLA HLA NNP cord-010119-t1x9gknd 6153 4 tying tie VBG cord-010119-t1x9gknd 6153 5 for for IN cord-010119-t1x9gknd 6153 6 the the DT cord-010119-t1x9gknd 6153 7 potential potential JJ cord-010119-t1x9gknd 6153 8 donors donor NNS cord-010119-t1x9gknd 6153 9 from from IN cord-010119-t1x9gknd 6153 10 CMDP CMDP NNP cord-010119-t1x9gknd 6153 11 were be VBD cord-010119-t1x9gknd 6153 12 performed perform VBN cord-010119-t1x9gknd 6153 13 by by IN cord-010119-t1x9gknd 6153 14 bi bi JJ cord-010119-t1x9gknd 6153 15 - - JJ cord-010119-t1x9gknd 6153 16 allelic allelic JJ cord-010119-t1x9gknd 6153 17 Sequence sequence NN cord-010119-t1x9gknd 6153 18 - - HYPH cord-010119-t1x9gknd 6153 19 Based base VBN cord-010119-t1x9gknd 6153 20 Typing typing NN cord-010119-t1x9gknd 6153 21 method method NN cord-010119-t1x9gknd 6153 22 , , , cord-010119-t1x9gknd 6153 23 using use VBG cord-010119-t1x9gknd 6153 24 a a DT cord-010119-t1x9gknd 6153 25 commercial commercial JJ cord-010119-t1x9gknd 6153 26 kit kit NN cord-010119-t1x9gknd 6153 27 ( ( -LRB- cord-010119-t1x9gknd 6153 28 ROSE ROSE NNP cord-010119-t1x9gknd 6153 29 Europe Europe NNP cord-010119-t1x9gknd 6153 30 GmbH GmbH NNP cord-010119-t1x9gknd 6153 31 , , , cord-010119-t1x9gknd 6153 32 Frankfurt Frankfurt NNP cord-010119-t1x9gknd 6153 33 , , , cord-010119-t1x9gknd 6153 34 Germany Germany NNP cord-010119-t1x9gknd 6153 35 ) ) -RRB- cord-010119-t1x9gknd 6153 36 . . . cord-010119-t1x9gknd 6154 1 In in IN cord-010119-t1x9gknd 6154 2 the the DT cord-010119-t1x9gknd 6154 3 case case NN cord-010119-t1x9gknd 6154 4 of of IN cord-010119-t1x9gknd 6154 5 no no DT cord-010119-t1x9gknd 6154 6 full full JJ cord-010119-t1x9gknd 6154 7 matched match VBN cord-010119-t1x9gknd 6154 8 HLA HLA NNP cord-010119-t1x9gknd 6154 9 typing typing NN cord-010119-t1x9gknd 6154 10 results result NNS cord-010119-t1x9gknd 6154 11 , , , cord-010119-t1x9gknd 6154 12 group group NN cord-010119-t1x9gknd 6154 13 specific specific JJ cord-010119-t1x9gknd 6154 14 HLAssure hlassure NN cord-010119-t1x9gknd 6154 15 - - HYPH cord-010119-t1x9gknd 6154 16 SE se NN cord-010119-t1x9gknd 6154 17 SBT SBT NNP cord-010119-t1x9gknd 6154 18 Typing typing NN cord-010119-t1x9gknd 6154 19 Kit kit NN cord-010119-t1x9gknd 6154 20 ( ( -LRB- cord-010119-t1x9gknd 6154 21 Texas Texas NNP cord-010119-t1x9gknd 6154 22 Biogene Biogene NNP cord-010119-t1x9gknd 6154 23 Inc. Inc. NNP cord-010119-t1x9gknd 6154 24 , , , cord-010119-t1x9gknd 6154 25 Taipei Taipei NNP cord-010119-t1x9gknd 6154 26 , , , cord-010119-t1x9gknd 6154 27 Taiwan Taiwan NNP cord-010119-t1x9gknd 6154 28 ) ) -RRB- cord-010119-t1x9gknd 6154 29 was be VBD cord-010119-t1x9gknd 6154 30 employed employ VBN cord-010119-t1x9gknd 6154 31 to to TO cord-010119-t1x9gknd 6154 32 identify identify VB cord-010119-t1x9gknd 6154 33 the the DT cord-010119-t1x9gknd 6154 34 nucleotide nucleotide JJ cord-010119-t1x9gknd 6154 35 sequences sequence NNS cord-010119-t1x9gknd 6154 36 of of IN cord-010119-t1x9gknd 6154 37 the the DT cord-010119-t1x9gknd 6154 38 novel novel JJ cord-010119-t1x9gknd 6154 39 allele allele NN cord-010119-t1x9gknd 6154 40 . . . cord-010119-t1x9gknd 6155 1 Fresh fresh JJ cord-010119-t1x9gknd 6155 2 blood blood NN cord-010119-t1x9gknd 6155 3 samples sample NNS cord-010119-t1x9gknd 6155 4 were be VBD cord-010119-t1x9gknd 6155 5 collected collect VBN cord-010119-t1x9gknd 6155 6 of of IN cord-010119-t1x9gknd 6155 7 the the DT cord-010119-t1x9gknd 6155 8 proband proband NN cord-010119-t1x9gknd 6155 9 and and CC cord-010119-t1x9gknd 6155 10 his -PRON- PRP$ cord-010119-t1x9gknd 6155 11 family family NN cord-010119-t1x9gknd 6155 12 members member NNS cord-010119-t1x9gknd 6155 13 with with IN cord-010119-t1x9gknd 6155 14 the the DT cord-010119-t1x9gknd 6155 15 consent consent NN cord-010119-t1x9gknd 6155 16 , , , cord-010119-t1x9gknd 6155 17 in in IN cord-010119-t1x9gknd 6155 18 order order NN cord-010119-t1x9gknd 6155 19 to to TO cord-010119-t1x9gknd 6155 20 nanalysis nanalysis VB cord-010119-t1x9gknd 6155 21 the the DT cord-010119-t1x9gknd 6155 22 serological serological JJ cord-010119-t1x9gknd 6155 23 reactivities reactivity NNS cord-010119-t1x9gknd 6155 24 and and CC cord-010119-t1x9gknd 6155 25 the the DT cord-010119-t1x9gknd 6155 26 possible possible JJ cord-010119-t1x9gknd 6155 27 haplotype haplotype NN cord-010119-t1x9gknd 6155 28 associations association NNS cord-010119-t1x9gknd 6155 29 to to IN cord-010119-t1x9gknd 6155 30 the the DT cord-010119-t1x9gknd 6155 31 novel novel JJ cord-010119-t1x9gknd 6155 32 allele allele NN cord-010119-t1x9gknd 6155 33 . . . cord-010119-t1x9gknd 6156 1 The the DT cord-010119-t1x9gknd 6156 2 HLA HLA NNP cord-010119-t1x9gknd 6156 3 serological serological JJ cord-010119-t1x9gknd 6156 4 specificity specificity NN cord-010119-t1x9gknd 6156 5 was be VBD cord-010119-t1x9gknd 6156 6 indicated indicate VBN cord-010119-t1x9gknd 6156 7 by by IN cord-010119-t1x9gknd 6156 8 One one CD cord-010119-t1x9gknd 6156 9 Lambda(ASN72D)HLA lambda(asn72d)hla JJ cord-010119-t1x9gknd 6156 10 kit kit NN cord-010119-t1x9gknd 6156 11 . . . cord-010119-t1x9gknd 6157 1 Results result NNS cord-010119-t1x9gknd 6157 2 / / SYM cord-010119-t1x9gknd 6157 3 Findings finding NNS cord-010119-t1x9gknd 6157 4 : : : cord-010119-t1x9gknd 6158 1 No no DT cord-010119-t1x9gknd 6158 2 full full JJ cord-010119-t1x9gknd 6158 3 matched match VBN cord-010119-t1x9gknd 6158 4 result result NN cord-010119-t1x9gknd 6158 5 was be VBD cord-010119-t1x9gknd 6158 6 obtained obtain VBN cord-010119-t1x9gknd 6158 7 at at IN cord-010119-t1x9gknd 6158 8 HLA HLA NNP cord-010119-t1x9gknd 6158 9 - - HYPH cord-010119-t1x9gknd 6158 10 A a DT cord-010119-t1x9gknd 6158 11 locus locus NN cord-010119-t1x9gknd 6158 12 in in IN cord-010119-t1x9gknd 6158 13 HLA HLA NNP cord-010119-t1x9gknd 6158 14 typing type VBG cord-010119-t1x9gknd 6158 15 for for IN cord-010119-t1x9gknd 6158 16 a a DT cord-010119-t1x9gknd 6158 17 donor donor NN cord-010119-t1x9gknd 6158 18 , , , cord-010119-t1x9gknd 6158 19 which which WDT cord-010119-t1x9gknd 6158 20 suggested suggest VBD cord-010119-t1x9gknd 6158 21 the the DT cord-010119-t1x9gknd 6158 22 possible possible JJ cord-010119-t1x9gknd 6158 23 existence existence NN cord-010119-t1x9gknd 6158 24 of of IN cord-010119-t1x9gknd 6158 25 a a DT cord-010119-t1x9gknd 6158 26 novel novel JJ cord-010119-t1x9gknd 6158 27 allele allele NN cord-010119-t1x9gknd 6158 28 . . . cord-010119-t1x9gknd 6159 1 The the DT cord-010119-t1x9gknd 6159 2 latter latter JJ cord-010119-t1x9gknd 6159 3 nanalysis nanalysis NN cord-010119-t1x9gknd 6159 4 indicated indicate VBD cord-010119-t1x9gknd 6159 5 that that IN cord-010119-t1x9gknd 6159 6 the the DT cord-010119-t1x9gknd 6159 7 proband proband NN cord-010119-t1x9gknd 6159 8 have have VBP cord-010119-t1x9gknd 6159 9 a a DT cord-010119-t1x9gknd 6159 10 nove1 nove1 JJ cord-010119-t1x9gknd 6159 11 nucleotide nucleotide JJ cord-010119-t1x9gknd 6159 12 sequences sequence NNS cord-010119-t1x9gknd 6159 13 at at IN cord-010119-t1x9gknd 6159 14 HLA HLA NNP cord-010119-t1x9gknd 6159 15 - - HYPH cord-010119-t1x9gknd 6159 16 A a DT cord-010119-t1x9gknd 6159 17 locus locus NN cord-010119-t1x9gknd 6159 18 , , , cord-010119-t1x9gknd 6159 19 the the DT cord-010119-t1x9gknd 6159 20 new new JJ cord-010119-t1x9gknd 6159 21 sequences sequence NNS cord-010119-t1x9gknd 6159 22 was be VBD cord-010119-t1x9gknd 6159 23 most most RBS cord-010119-t1x9gknd 6159 24 close close JJ cord-010119-t1x9gknd 6159 25 to to IN cord-010119-t1x9gknd 6159 26 those those DT cord-010119-t1x9gknd 6159 27 of of IN cord-010119-t1x9gknd 6159 28 HLA HLA NNP cord-010119-t1x9gknd 6159 29 - - HYPH cord-010119-t1x9gknd 6159 30 A A NNP cord-010119-t1x9gknd 6159 31 * * NFP cord-010119-t1x9gknd 6159 32 26:01:01:01 26:01:01:01 CD cord-010119-t1x9gknd 6159 33 , , , cord-010119-t1x9gknd 6159 34 but but CC cord-010119-t1x9gknd 6159 35 1 1 CD cord-010119-t1x9gknd 6159 36 nucleotide nucleotide JJ cord-010119-t1x9gknd 6159 37 substitution substitution NN cord-010119-t1x9gknd 6159 38 in in IN cord-010119-t1x9gknd 6159 39 exon exon NN cord-010119-t1x9gknd 6159 40 4 4 CD cord-010119-t1x9gknd 6159 41 , , , cord-010119-t1x9gknd 6159 42 by by IN cord-010119-t1x9gknd 6159 43 nt nt RB cord-010119-t1x9gknd 6159 44 746 746 CD cord-010119-t1x9gknd 6159 45 C C NNP cord-010119-t1x9gknd 6159 46 - - HYPH cord-010119-t1x9gknd 6159 47 A A NNP cord-010119-t1x9gknd 6159 48 ( ( -LRB- cord-010119-t1x9gknd 6159 49 codon225 codon225 JJ cord-010119-t1x9gknd 6159 50 ACC ACC NNP cord-010119-t1x9gknd 6159 51 - - HYPH cord-010119-t1x9gknd 6159 52 AAC AAC NNP cord-010119-t1x9gknd 6159 53 ) ) -RRB- cord-010119-t1x9gknd 6159 54 , , , cord-010119-t1x9gknd 6159 55 which which WDT cord-010119-t1x9gknd 6159 56 resulted result VBD cord-010119-t1x9gknd 6159 57 in in IN cord-010119-t1x9gknd 6159 58 one one CD cord-010119-t1x9gknd 6159 59 aminoacid aminoacid JJ cord-010119-t1x9gknd 6159 60 substitution substitution NN cord-010119-t1x9gknd 6159 61 , , , cord-010119-t1x9gknd 6159 62 Thr Thr NNP cord-010119-t1x9gknd 6159 63 - - HYPH cord-010119-t1x9gknd 6159 64 Asn Asn NNP cord-010119-t1x9gknd 6159 65 . . . cord-010119-t1x9gknd 6160 1 The the DT cord-010119-t1x9gknd 6160 2 novel novel JJ cord-010119-t1x9gknd 6160 3 HLA HLA NNP cord-010119-t1x9gknd 6160 4 - - HYPH cord-010119-t1x9gknd 6160 5 A a DT cord-010119-t1x9gknd 6160 6 allele allele NN cord-010119-t1x9gknd 6160 7 was be VBD cord-010119-t1x9gknd 6160 8 officially officially RB cord-010119-t1x9gknd 6160 9 named name VBN cord-010119-t1x9gknd 6160 10 as as IN cord-010119-t1x9gknd 6160 11 HLA HLA NNP cord-010119-t1x9gknd 6160 12 - - HYPH cord-010119-t1x9gknd 6160 13 A A NNP cord-010119-t1x9gknd 6160 14 Background Background NNP cord-010119-t1x9gknd 6160 15 / / SYM cord-010119-t1x9gknd 6160 16 Case Case NNP cord-010119-t1x9gknd 6160 17 Studies Studies NNPS cord-010119-t1x9gknd 6160 18 : : : cord-010119-t1x9gknd 6160 19 Anti Anti NNP cord-010119-t1x9gknd 6160 20 - - NNP cord-010119-t1x9gknd 6160 21 D D NNP cord-010119-t1x9gknd 6160 22 is be VBZ cord-010119-t1x9gknd 6160 23 a a DT cord-010119-t1x9gknd 6160 24 frequent frequent JJ cord-010119-t1x9gknd 6160 25 cause cause NN cord-010119-t1x9gknd 6160 26 of of IN cord-010119-t1x9gknd 6160 27 hemolytic hemolytic JJ cord-010119-t1x9gknd 6160 28 disease disease NN cord-010119-t1x9gknd 6160 29 of of IN cord-010119-t1x9gknd 6160 30 the the DT cord-010119-t1x9gknd 6160 31 fetus fetus NN cord-010119-t1x9gknd 6160 32 and and CC cord-010119-t1x9gknd 6160 33 newborn newborn JJ cord-010119-t1x9gknd 6160 34 ( ( -LRB- cord-010119-t1x9gknd 6160 35 HDFN HDFN NNP cord-010119-t1x9gknd 6160 36 ) ) -RRB- cord-010119-t1x9gknd 6160 37 . . . cord-010119-t1x9gknd 6161 1 As as IN cord-010119-t1x9gknd 6161 2 a a DT cord-010119-t1x9gknd 6161 3 rule rule NN cord-010119-t1x9gknd 6161 4 , , , cord-010119-t1x9gknd 6161 5 immunization immunization NN cord-010119-t1x9gknd 6161 6 occurs occur VBZ cord-010119-t1x9gknd 6161 7 in in IN cord-010119-t1x9gknd 6161 8 D d DT cord-010119-t1x9gknd 6161 9 negative negative JJ cord-010119-t1x9gknd 6161 10 pregnant pregnant JJ cord-010119-t1x9gknd 6161 11 women woman NNS cord-010119-t1x9gknd 6161 12 , , , cord-010119-t1x9gknd 6161 13 but but CC cord-010119-t1x9gknd 6161 14 occasionally occasionally RB cord-010119-t1x9gknd 6161 15 anti anti JJ cord-010119-t1x9gknd 6161 16 - - JJ cord-010119-t1x9gknd 6161 17 D d JJ cord-010119-t1x9gknd 6161 18 is be VBZ cord-010119-t1x9gknd 6161 19 also also RB cord-010119-t1x9gknd 6161 20 observed observe VBN cord-010119-t1x9gknd 6161 21 in in IN cord-010119-t1x9gknd 6161 22 carriers carrier NNS cord-010119-t1x9gknd 6161 23 of of IN cord-010119-t1x9gknd 6161 24 D d NN cord-010119-t1x9gknd 6161 25 variants variant NNS cord-010119-t1x9gknd 6161 26 . . . cord-010119-t1x9gknd 6162 1 Currently currently RB cord-010119-t1x9gknd 6162 2 , , , cord-010119-t1x9gknd 6162 3 maternal maternal JJ cord-010119-t1x9gknd 6162 4 plasma plasma NN cord-010119-t1x9gknd 6162 5 analysis analysis NN cord-010119-t1x9gknd 6162 6 for for IN cord-010119-t1x9gknd 6162 7 determination determination NN cord-010119-t1x9gknd 6162 8 of of IN cord-010119-t1x9gknd 6162 9 the the DT cord-010119-t1x9gknd 6162 10 fetal fetal JJ cord-010119-t1x9gknd 6162 11 RHD rhd NN cord-010119-t1x9gknd 6162 12 status status NN cord-010119-t1x9gknd 6162 13 became become VBD cord-010119-t1x9gknd 6162 14 an an DT cord-010119-t1x9gknd 6162 15 exciting exciting JJ cord-010119-t1x9gknd 6162 16 new new JJ cord-010119-t1x9gknd 6162 17 tool tool NN cord-010119-t1x9gknd 6162 18 for for IN cord-010119-t1x9gknd 6162 19 the the DT cord-010119-t1x9gknd 6162 20 management management NN cord-010119-t1x9gknd 6162 21 of of IN cord-010119-t1x9gknd 6162 22 D d JJ cord-010119-t1x9gknd 6162 23 - - HYPH cord-010119-t1x9gknd 6162 24 negative negative JJ cord-010119-t1x9gknd 6162 25 pregnant pregnant JJ cord-010119-t1x9gknd 6162 26 women woman NNS cord-010119-t1x9gknd 6162 27 , , , cord-010119-t1x9gknd 6162 28 but but CC cord-010119-t1x9gknd 6162 29 one one CD cord-010119-t1x9gknd 6162 30 of of IN cord-010119-t1x9gknd 6162 31 the the DT cord-010119-t1x9gknd 6162 32 challenges challenge NNS cord-010119-t1x9gknd 6162 33 in in IN cord-010119-t1x9gknd 6162 34 non non JJ cord-010119-t1x9gknd 6162 35 invasive invasive JJ cord-010119-t1x9gknd 6162 36 fetal fetal JJ cord-010119-t1x9gknd 6162 37 RHDgenotyping rhdgenotyping NN cord-010119-t1x9gknd 6162 38 is be VBZ cord-010119-t1x9gknd 6162 39 the the DT cord-010119-t1x9gknd 6162 40 presence presence NN cord-010119-t1x9gknd 6162 41 of of IN cord-010119-t1x9gknd 6162 42 D d NN cord-010119-t1x9gknd 6162 43 variants variant NNS cord-010119-t1x9gknd 6162 44 in in IN cord-010119-t1x9gknd 6162 45 the the DT cord-010119-t1x9gknd 6162 46 pregnant pregnant JJ cord-010119-t1x9gknd 6162 47 women woman NNS cord-010119-t1x9gknd 6162 48 . . . cord-010119-t1x9gknd 6163 1 We -PRON- PRP cord-010119-t1x9gknd 6163 2 present present VBP cord-010119-t1x9gknd 6163 3 a a DT cord-010119-t1x9gknd 6163 4 case case NN cord-010119-t1x9gknd 6163 5 of of IN cord-010119-t1x9gknd 6163 6 a a DT cord-010119-t1x9gknd 6163 7 13 13 CD cord-010119-t1x9gknd 6163 8 year year NN cord-010119-t1x9gknd 6163 9 - - HYPH cord-010119-t1x9gknd 6163 10 old old JJ cord-010119-t1x9gknd 6163 11 pregnant pregnant JJ cord-010119-t1x9gknd 6163 12 woman woman NN cord-010119-t1x9gknd 6163 13 typed type VBN cord-010119-t1x9gknd 6163 14 as as IN cord-010119-t1x9gknd 6163 15 AB1 AB1 NNP cord-010119-t1x9gknd 6163 16 , , , cord-010119-t1x9gknd 6163 17 who who WP cord-010119-t1x9gknd 6163 18 delivered deliver VBD cord-010119-t1x9gknd 6163 19 a a DT cord-010119-t1x9gknd 6163 20 baby baby NN cord-010119-t1x9gknd 6163 21 affected affect VBN cord-010119-t1x9gknd 6163 22 by by IN cord-010119-t1x9gknd 6163 23 severe severe JJ cord-010119-t1x9gknd 6163 24 HDFN HDFN NNP cord-010119-t1x9gknd 6163 25 . . . cord-010119-t1x9gknd 6164 1 The the DT cord-010119-t1x9gknd 6164 2 newborn newborn NN cord-010119-t1x9gknd 6164 3 was be VBD cord-010119-t1x9gknd 6164 4 typed type VBN cord-010119-t1x9gknd 6164 5 as as IN cord-010119-t1x9gknd 6164 6 B1 b1 NN cord-010119-t1x9gknd 6164 7 and and CC cord-010119-t1x9gknd 6164 8 presented present VBD cord-010119-t1x9gknd 6164 9 a a DT cord-010119-t1x9gknd 6164 10 positive positive JJ cord-010119-t1x9gknd 6164 11 direct direct JJ cord-010119-t1x9gknd 6164 12 antiglobulin antiglobulin NN cord-010119-t1x9gknd 6164 13 test test NN cord-010119-t1x9gknd 6164 14 ( ( -LRB- cord-010119-t1x9gknd 6164 15 DAT DAT NNP cord-010119-t1x9gknd 6164 16 ) ) -RRB- cord-010119-t1x9gknd 6164 17 with with IN cord-010119-t1x9gknd 6164 18 an an DT cord-010119-t1x9gknd 6164 19 anti anti JJ cord-010119-t1x9gknd 6164 20 - - JJ cord-010119-t1x9gknd 6164 21 D d JJ cord-010119-t1x9gknd 6164 22 identified identify VBN cord-010119-t1x9gknd 6164 23 in in IN cord-010119-t1x9gknd 6164 24 the the DT cord-010119-t1x9gknd 6164 25 eluate eluate NN cord-010119-t1x9gknd 6164 26 . . . cord-010119-t1x9gknd 6165 1 The the DT cord-010119-t1x9gknd 6165 2 baby baby NN cord-010119-t1x9gknd 6165 3 was be VBD cord-010119-t1x9gknd 6165 4 treated treat VBN cord-010119-t1x9gknd 6165 5 by by IN cord-010119-t1x9gknd 6165 6 exchange exchange NN cord-010119-t1x9gknd 6165 7 transfusion transfusion NN cord-010119-t1x9gknd 6165 8 and and CC cord-010119-t1x9gknd 6165 9 the the DT cord-010119-t1x9gknd 6165 10 mother mother NN cord-010119-t1x9gknd 6165 11 's 's POS cord-010119-t1x9gknd 6165 12 sample sample NN cord-010119-t1x9gknd 6165 13 was be VBD cord-010119-t1x9gknd 6165 14 investigated investigate VBN cord-010119-t1x9gknd 6165 15 . . . cord-010119-t1x9gknd 6166 1 Study Study NNP cord-010119-t1x9gknd 6166 2 Design Design NNP cord-010119-t1x9gknd 6166 3 / / SYM cord-010119-t1x9gknd 6166 4 Method method NN cord-010119-t1x9gknd 6166 5 : : : cord-010119-t1x9gknd 6166 6 Serologic Serologic NNP cord-010119-t1x9gknd 6166 7 testing testing NN cord-010119-t1x9gknd 6166 8 was be VBD cord-010119-t1x9gknd 6166 9 done do VBN cord-010119-t1x9gknd 6166 10 by by IN cord-010119-t1x9gknd 6166 11 hemagglutination hemagglutination NN cord-010119-t1x9gknd 6166 12 in in IN cord-010119-t1x9gknd 6166 13 gel gel NN cord-010119-t1x9gknd 6166 14 cards card NNS cord-010119-t1x9gknd 6166 15 . . . cord-010119-t1x9gknd 6167 1 Genomic genomic JJ cord-010119-t1x9gknd 6167 2 DNA dna NN cord-010119-t1x9gknd 6167 3 was be VBD cord-010119-t1x9gknd 6167 4 extracted extract VBN cord-010119-t1x9gknd 6167 5 from from IN cord-010119-t1x9gknd 6167 6 whole whole JJ cord-010119-t1x9gknd 6167 7 blood blood NN cord-010119-t1x9gknd 6167 8 by by IN cord-010119-t1x9gknd 6167 9 spin spin NN cord-010119-t1x9gknd 6167 10 column column NN cord-010119-t1x9gknd 6167 11 and and CC cord-010119-t1x9gknd 6167 12 all all DT cord-010119-t1x9gknd 6167 13 RHD RHD NNP cord-010119-t1x9gknd 6167 14 exons exon NNS cord-010119-t1x9gknd 6167 15 were be VBD cord-010119-t1x9gknd 6167 16 sequenced sequence VBN cord-010119-t1x9gknd 6167 17 by by IN cord-010119-t1x9gknd 6167 18 Sanger Sanger NNP cord-010119-t1x9gknd 6167 19 sequence sequence NN cord-010119-t1x9gknd 6167 20 method method NN cord-010119-t1x9gknd 6167 21 . . . cord-010119-t1x9gknd 6168 1 Results/ Results/ . cord-010119-t1x9gknd 6169 1 Finding finding NN cord-010119-t1x9gknd 6169 2 : : : cord-010119-t1x9gknd 6169 3 The the DT cord-010119-t1x9gknd 6169 4 mother mother NN cord-010119-t1x9gknd 6169 5 's 's POS cord-010119-t1x9gknd 6169 6 RBCs rbc NNS cord-010119-t1x9gknd 6169 7 reacted react VBD cord-010119-t1x9gknd 6169 8 41 41 CD cord-010119-t1x9gknd 6169 9 with with IN cord-010119-t1x9gknd 6169 10 the the DT cord-010119-t1x9gknd 6169 11 four four CD cord-010119-t1x9gknd 6169 12 monoclonal monoclonal JJ cord-010119-t1x9gknd 6169 13 anti anti JJ cord-010119-t1x9gknd 6169 14 - - JJ cord-010119-t1x9gknd 6169 15 D d JJ cord-010119-t1x9gknd 6169 16 used use VBN cord-010119-t1x9gknd 6169 17 ( ( -LRB- cord-010119-t1x9gknd 6169 18 IgM IgM NNP cord-010119-t1x9gknd 6169 19 clones clones NNP cord-010119-t1x9gknd 6169 20 P3x61 P3x61 NNP cord-010119-t1x9gknd 6169 21 and and CC cord-010119-t1x9gknd 6169 22 RUM RUM NNP cord-010119-t1x9gknd 6169 23 1 1 CD cord-010119-t1x9gknd 6169 24 and and CC cord-010119-t1x9gknd 6169 25 the the DT cord-010119-t1x9gknd 6169 26 blends blend NNS cord-010119-t1x9gknd 6169 27 clones clone NNS cord-010119-t1x9gknd 6169 28 TH281MS26 TH281MS26 NNP cord-010119-t1x9gknd 6169 29 and and CC cord-010119-t1x9gknd 6169 30 D1751D415 D1751D415 NNPS cord-010119-t1x9gknd 6169 31 ) ) -RRB- cord-010119-t1x9gknd 6169 32 and and CC cord-010119-t1x9gknd 6169 33 were be VBD cord-010119-t1x9gknd 6169 34 typed type VBN cord-010119-t1x9gknd 6169 35 as as IN cord-010119-t1x9gknd 6169 36 C C NNP cord-010119-t1x9gknd 6169 37 - - HYPH cord-010119-t1x9gknd 6169 38 c1E c1E NNP cord-010119-t1x9gknd 6169 39 - - HYPH cord-010119-t1x9gknd 6169 40 e1 e1 NNP cord-010119-t1x9gknd 6169 41 . . . cord-010119-t1x9gknd 6170 1 An an DT cord-010119-t1x9gknd 6170 2 anti anti JJ cord-010119-t1x9gknd 6170 3 - - JJ cord-010119-t1x9gknd 6170 4 D d JJ cord-010119-t1x9gknd 6170 5 was be VBD cord-010119-t1x9gknd 6170 6 identified identify VBN cord-010119-t1x9gknd 6170 7 in in IN cord-010119-t1x9gknd 6170 8 her -PRON- PRP$ cord-010119-t1x9gknd 6170 9 serum serum NN cord-010119-t1x9gknd 6170 10 . . . cord-010119-t1x9gknd 6171 1 Molecular molecular JJ cord-010119-t1x9gknd 6171 2 analysis analysis NN cord-010119-t1x9gknd 6171 3 showed show VBD cord-010119-t1x9gknd 6171 4 the the DT cord-010119-t1x9gknd 6171 5 410C 410c CD cord-010119-t1x9gknd 6172 1 > > XX cord-010119-t1x9gknd 6173 1 T T NNP cord-010119-t1x9gknd 6173 2 and and CC cord-010119-t1x9gknd 6173 3 455A 455a CD cord-010119-t1x9gknd 6174 1 > > XX cord-010119-t1x9gknd 6175 1 C C NNP cord-010119-t1x9gknd 6175 2 in in IN cord-010119-t1x9gknd 6175 3 exon exon NN cord-010119-t1x9gknd 6175 4 3 3 CD cord-010119-t1x9gknd 6175 5 , , , cord-010119-t1x9gknd 6175 6 the the DT cord-010119-t1x9gknd 6175 7 SNP SNP NNP cord-010119-t1x9gknd 6175 8 509 509 CD cord-010119-t1x9gknd 6175 9 T T NNP cord-010119-t1x9gknd 6176 1 > > XX cord-010119-t1x9gknd 6177 1 C C NNP cord-010119-t1x9gknd 6177 2 changes change NNS cord-010119-t1x9gknd 6177 3 in in IN cord-010119-t1x9gknd 6177 4 exon exon NN cord-010119-t1x9gknd 6177 5 4 4 CD cord-010119-t1x9gknd 6177 6 and and CC cord-010119-t1x9gknd 6177 7 the the DT cord-010119-t1x9gknd 6177 8 667 667 CD cord-010119-t1x9gknd 6177 9 T t NN cord-010119-t1x9gknd 6178 1 > > XX cord-010119-t1x9gknd 6179 1 G g NN cord-010119-t1x9gknd 6179 2 nucleotide nucleotide JJ cord-010119-t1x9gknd 6179 3 change change NN cord-010119-t1x9gknd 6179 4 in in IN cord-010119-t1x9gknd 6179 5 exon exon NN cord-010119-t1x9gknd 6179 6 5 5 CD cord-010119-t1x9gknd 6179 7 . . . cord-010119-t1x9gknd 6180 1 The the DT cord-010119-t1x9gknd 6180 2 set set NN cord-010119-t1x9gknd 6180 3 of of IN cord-010119-t1x9gknd 6180 4 SNPs SNPs NNPS cord-010119-t1x9gknd 6180 5 found find VBN cord-010119-t1x9gknd 6180 6 is be VBZ cord-010119-t1x9gknd 6180 7 similar similar JJ cord-010119-t1x9gknd 6180 8 to to IN cord-010119-t1x9gknd 6180 9 the the DT cord-010119-t1x9gknd 6180 10 molecular molecular JJ cord-010119-t1x9gknd 6180 11 background background NN cord-010119-t1x9gknd 6180 12 of of IN cord-010119-t1x9gknd 6180 13 DOL3 DOL3 NNP cord-010119-t1x9gknd 6180 14 , , , cord-010119-t1x9gknd 6180 15 except except IN cord-010119-t1x9gknd 6180 16 for for IN cord-010119-t1x9gknd 6180 17 455A 455a CD cord-010119-t1x9gknd 6180 18 > > XX cord-010119-t1x9gknd 6180 19 C c NN cord-010119-t1x9gknd 6180 20 change change NN cord-010119-t1x9gknd 6180 21 . . . cord-010119-t1x9gknd 6181 1 Conclusion conclusion NN cord-010119-t1x9gknd 6181 2 : : : cord-010119-t1x9gknd 6182 1 This this DT cord-010119-t1x9gknd 6182 2 novel novel NN cord-010119-t1x9gknd 6182 3 set set NN cord-010119-t1x9gknd 6182 4 of of IN cord-010119-t1x9gknd 6182 5 SNPs SNPs NNPS cord-010119-t1x9gknd 6182 6 found find VBN cord-010119-t1x9gknd 6182 7 in in IN cord-010119-t1x9gknd 6182 8 this this DT cord-010119-t1x9gknd 6182 9 mother mother NN cord-010119-t1x9gknd 6182 10 is be VBZ cord-010119-t1x9gknd 6182 11 related relate VBN cord-010119-t1x9gknd 6182 12 to to IN cord-010119-t1x9gknd 6182 13 a a DT cord-010119-t1x9gknd 6182 14 novel novel JJ cord-010119-t1x9gknd 6182 15 RHD RHD NNP cord-010119-t1x9gknd 6182 16 allele allele NN cord-010119-t1x9gknd 6182 17 leading lead VBG cord-010119-t1x9gknd 6182 18 to to IN cord-010119-t1x9gknd 6182 19 a a DT cord-010119-t1x9gknd 6182 20 partial partial JJ cord-010119-t1x9gknd 6182 21 D d NN cord-010119-t1x9gknd 6182 22 antigen antigen NN cord-010119-t1x9gknd 6182 23 involved involve VBN cord-010119-t1x9gknd 6182 24 in in IN cord-010119-t1x9gknd 6182 25 the the DT cord-010119-t1x9gknd 6182 26 production production NN cord-010119-t1x9gknd 6182 27 of of IN cord-010119-t1x9gknd 6182 28 an an DT cord-010119-t1x9gknd 6182 29 anti anti JJ cord-010119-t1x9gknd 6182 30 - - JJ cord-010119-t1x9gknd 6182 31 D d JJ cord-010119-t1x9gknd 6182 32 that that WDT cord-010119-t1x9gknd 6182 33 can can MD cord-010119-t1x9gknd 6182 34 cause cause VB cord-010119-t1x9gknd 6182 35 severe severe JJ cord-010119-t1x9gknd 6182 36 HDFN HDFN NNP cord-010119-t1x9gknd 6182 37 . . . cord-010119-t1x9gknd 6183 1 This this DT cord-010119-t1x9gknd 6183 2 finding finding NN cord-010119-t1x9gknd 6183 3 shows show VBZ cord-010119-t1x9gknd 6183 4 the the DT cord-010119-t1x9gknd 6183 5 need need NN cord-010119-t1x9gknd 6183 6 to to TO cord-010119-t1x9gknd 6183 7 elucidate elucidate VB cord-010119-t1x9gknd 6183 8 the the DT cord-010119-t1x9gknd 6183 9 clinical clinical JJ cord-010119-t1x9gknd 6183 10 significance significance NN cord-010119-t1x9gknd 6183 11 of of IN cord-010119-t1x9gknd 6183 12 different different JJ cord-010119-t1x9gknd 6183 13 RHD RHD NNP cord-010119-t1x9gknd 6183 14 genotypes genotype NNS cord-010119-t1x9gknd 6183 15 in in IN cord-010119-t1x9gknd 6183 16 various various JJ cord-010119-t1x9gknd 6183 17 ethnic ethnic JJ cord-010119-t1x9gknd 6183 18 backgrounds background NNS cord-010119-t1x9gknd 6183 19 . . . cord-010119-t1x9gknd 6184 1 The the DT cord-010119-t1x9gknd 6184 2 and and CC cord-010119-t1x9gknd 6184 3 Erytra Erytra NNP cord-010119-t1x9gknd 6184 4 V v NN cord-010119-t1x9gknd 6184 5 R r NN cord-010119-t1x9gknd 6184 6 ( ( -LRB- cord-010119-t1x9gknd 6184 7 the the DT cord-010119-t1x9gknd 6184 8 routine routine JJ cord-010119-t1x9gknd 6184 9 reference reference NN cord-010119-t1x9gknd 6184 10 platform platform NN cord-010119-t1x9gknd 6184 11 ) ) -RRB- cord-010119-t1x9gknd 6184 12 was be VBD cord-010119-t1x9gknd 6184 13 performed perform VBN cord-010119-t1x9gknd 6184 14 . . . cord-010119-t1x9gknd 6185 1 A a DT cord-010119-t1x9gknd 6185 2 total total NN cord-010119-t1x9gknd 6185 3 of of IN cord-010119-t1x9gknd 6185 4 1089 1089 CD cord-010119-t1x9gknd 6185 5 immuno immuno JJ cord-010119-t1x9gknd 6185 6 hematological hematological JJ cord-010119-t1x9gknd 6185 7 tests test NNS cord-010119-t1x9gknd 6185 8 ( ( -LRB- cord-010119-t1x9gknd 6185 9 465 465 CD cord-010119-t1x9gknd 6185 10 ABO ABO NNP cord-010119-t1x9gknd 6185 11 / / SYM cord-010119-t1x9gknd 6185 12 D d NN cord-010119-t1x9gknd 6185 13 grouping grouping NN cord-010119-t1x9gknd 6185 14 ( ( -LRB- cord-010119-t1x9gknd 6185 15 including include VBG cord-010119-t1x9gknd 6185 16 33 33 CD cord-010119-t1x9gknd 6185 17 newborn newborn JJ cord-010119-t1x9gknd 6185 18 samples sample NNS cord-010119-t1x9gknd 6185 19 ) ) -RRB- cord-010119-t1x9gknd 6185 20 , , , cord-010119-t1x9gknd 6185 21 12 12 CD cord-010119-t1x9gknd 6185 22 extended extend VBN cord-010119-t1x9gknd 6185 23 erythrocytic erythrocytic JJ cord-010119-t1x9gknd 6185 24 phenotype phenotype NN cord-010119-t1x9gknd 6185 25 , , , cord-010119-t1x9gknd 6185 26 562 562 CD cord-010119-t1x9gknd 6185 27 antibody antibody NN cord-010119-t1x9gknd 6185 28 screening screening NN cord-010119-t1x9gknd 6185 29 , , , cord-010119-t1x9gknd 6185 30 14 14 CD cord-010119-t1x9gknd 6185 31 antibody antibody NN cord-010119-t1x9gknd 6185 32 identification identification NN cord-010119-t1x9gknd 6185 33 , , , cord-010119-t1x9gknd 6185 34 16 16 CD cord-010119-t1x9gknd 6185 35 DAT DAT NNP cord-010119-t1x9gknd 6185 36 ) ) -RRB- cord-010119-t1x9gknd 6185 37 and and CC cord-010119-t1x9gknd 6185 38 20 20 CD cord-010119-t1x9gknd 6185 39 crossmatches crossmatche NNS cord-010119-t1x9gknd 6185 40 were be VBD cord-010119-t1x9gknd 6185 41 performed perform VBN cord-010119-t1x9gknd 6185 42 on on IN cord-010119-t1x9gknd 6185 43 patient patient NN cord-010119-t1x9gknd 6185 44 's 's POS cord-010119-t1x9gknd 6185 45 whole whole JJ cord-010119-t1x9gknd 6185 46 blood blood NN cord-010119-t1x9gknd 6185 47 samples sample NNS cord-010119-t1x9gknd 6185 48 . . . cord-010119-t1x9gknd 6186 1 The the DT cord-010119-t1x9gknd 6186 2 Erytra Erytra NNP cord-010119-t1x9gknd 6186 3 Eflexis Eflexis NNP cord-010119-t1x9gknd 6186 4 V v NN cord-010119-t1x9gknd 6186 5 R r NN cord-010119-t1x9gknd 6186 6 performance performance NN cord-010119-t1x9gknd 6186 7 was be VBD cord-010119-t1x9gknd 6186 8 evaluated evaluate VBN cord-010119-t1x9gknd 6186 9 according accord VBG cord-010119-t1x9gknd 6186 10 to to IN cord-010119-t1x9gknd 6186 11 a a DT cord-010119-t1x9gknd 6186 12 protocol protocol NN cord-010119-t1x9gknd 6186 13 that that WDT cord-010119-t1x9gknd 6186 14 was be VBD cord-010119-t1x9gknd 6186 15 designed design VBN cord-010119-t1x9gknd 6186 16 to to TO cord-010119-t1x9gknd 6186 17 simulate simulate VB cord-010119-t1x9gknd 6186 18 the the DT cord-010119-t1x9gknd 6186 19 routine routine JJ cord-010119-t1x9gknd 6186 20 workload workload NN cord-010119-t1x9gknd 6186 21 using use VBG cord-010119-t1x9gknd 6186 22 the the DT cord-010119-t1x9gknd 6186 23 system system NN cord-010119-t1x9gknd 6186 24 in in IN cord-010119-t1x9gknd 6186 25 its -PRON- PRP$ cord-010119-t1x9gknd 6186 26 two two CD cord-010119-t1x9gknd 6186 27 different different JJ cord-010119-t1x9gknd 6186 28 configurations configuration NNS cord-010119-t1x9gknd 6186 29 . . . cord-010119-t1x9gknd 6187 1 Concordance concordance NN cord-010119-t1x9gknd 6187 2 between between IN cord-010119-t1x9gknd 6187 3 systems system NNS cord-010119-t1x9gknd 6187 4 was be VBD cord-010119-t1x9gknd 6187 5 assessed assess VBN cord-010119-t1x9gknd 6187 6 and and CC cord-010119-t1x9gknd 6187 7 discrepancies discrepancy NNS cord-010119-t1x9gknd 6187 8 were be VBD cord-010119-t1x9gknd 6187 9 analyzed analyze VBN cord-010119-t1x9gknd 6187 10 . . . cord-010119-t1x9gknd 6188 1 The the DT cord-010119-t1x9gknd 6188 2 following follow VBG cord-010119-t1x9gknd 6188 3 performance performance NN cord-010119-t1x9gknd 6188 4 metrics metric NNS cord-010119-t1x9gknd 6188 5 were be VBD cord-010119-t1x9gknd 6188 6 assessed assess VBN cord-010119-t1x9gknd 6188 7 : : : cord-010119-t1x9gknd 6188 8 time time NN cord-010119-t1x9gknd 6188 9 to to IN cord-010119-t1x9gknd 6188 10 first first JJ cord-010119-t1x9gknd 6188 11 result result NN cord-010119-t1x9gknd 6188 12 ( ( -LRB- cord-010119-t1x9gknd 6188 13 TTFR TTFR NNP cord-010119-t1x9gknd 6188 14 ) ) -RRB- cord-010119-t1x9gknd 6188 15 , , , cord-010119-t1x9gknd 6188 16 turn turn VB cord-010119-t1x9gknd 6188 17 - - HYPH cord-010119-t1x9gknd 6188 18 around around RP cord-010119-t1x9gknd 6188 19 time time NN cord-010119-t1x9gknd 6188 20 ( ( -LRB- cord-010119-t1x9gknd 6188 21 TAT tat NN cord-010119-t1x9gknd 6188 22 ) ) -RRB- cord-010119-t1x9gknd 6188 23 for for IN cord-010119-t1x9gknd 6188 24 the the DT cord-010119-t1x9gknd 6188 25 total total JJ cord-010119-t1x9gknd 6188 26 workload workload NN cord-010119-t1x9gknd 6188 27 from from IN cord-010119-t1x9gknd 6188 28 first first JJ cord-010119-t1x9gknd 6188 29 result result NN cord-010119-t1x9gknd 6188 30 to to IN cord-010119-t1x9gknd 6188 31 last last JJ cord-010119-t1x9gknd 6188 32 result result NN cord-010119-t1x9gknd 6188 33 ( ( -LRB- cord-010119-t1x9gknd 6188 34 throughput throughput NN cord-010119-t1x9gknd 6188 35 , , , cord-010119-t1x9gknd 6188 36 results result NNS cord-010119-t1x9gknd 6188 37 / / SYM cord-010119-t1x9gknd 6188 38 h h NN cord-010119-t1x9gknd 6188 39 ) ) -RRB- cord-010119-t1x9gknd 6188 40 , , , cord-010119-t1x9gknd 6188 41 and and CC cord-010119-t1x9gknd 6188 42 manual manual JJ cord-010119-t1x9gknd 6188 43 " " `` cord-010119-t1x9gknd 6188 44 handson handson JJ cord-010119-t1x9gknd 6188 45 " " '' cord-010119-t1x9gknd 6188 46 time time NN cord-010119-t1x9gknd 6188 47 required require VBN cord-010119-t1x9gknd 6188 48 as as RB cord-010119-t1x9gknd 6188 49 well well RB cord-010119-t1x9gknd 6188 50 as as IN cord-010119-t1x9gknd 6188 51 walk walk NN cord-010119-t1x9gknd 6188 52 - - HYPH cord-010119-t1x9gknd 6188 53 away away RP cord-010119-t1x9gknd 6188 54 time time NN cord-010119-t1x9gknd 6188 55 , , , cord-010119-t1x9gknd 6188 56 considering consider VBG cord-010119-t1x9gknd 6188 57 the the DT cord-010119-t1x9gknd 6188 58 two two CD cord-010119-t1x9gknd 6188 59 different different JJ cord-010119-t1x9gknd 6188 60 configurations configuration NNS cord-010119-t1x9gknd 6188 61 of of IN cord-010119-t1x9gknd 6188 62 the the DT cord-010119-t1x9gknd 6188 63 system system NN cord-010119-t1x9gknd 6188 64 . . . cord-010119-t1x9gknd 6189 1 For for IN cord-010119-t1x9gknd 6189 2 the the DT cord-010119-t1x9gknd 6189 3 ease ease NN cord-010119-t1x9gknd 6189 4 of of IN cord-010119-t1x9gknd 6189 5 use use NN cord-010119-t1x9gknd 6189 6 evaluation evaluation NN cord-010119-t1x9gknd 6189 7 , , , cord-010119-t1x9gknd 6189 8 different different JJ cord-010119-t1x9gknd 6189 9 usability usability NN cord-010119-t1x9gknd 6189 10 features feature NNS cord-010119-t1x9gknd 6189 11 were be VBD cord-010119-t1x9gknd 6189 12 ranked rank VBN cord-010119-t1x9gknd 6189 13 and and CC cord-010119-t1x9gknd 6189 14 the the DT cord-010119-t1x9gknd 6189 15 number number NN cord-010119-t1x9gknd 6189 16 of of IN cord-010119-t1x9gknd 6189 17 steps step NNS cord-010119-t1x9gknd 6189 18 and and CC cord-010119-t1x9gknd 6189 19 timing timing NN cord-010119-t1x9gknd 6189 20 of of IN cord-010119-t1x9gknd 6189 21 the the DT cord-010119-t1x9gknd 6189 22 following follow VBG cord-010119-t1x9gknd 6189 23 activities activity NNS cord-010119-t1x9gknd 6189 24 were be VBD cord-010119-t1x9gknd 6189 25 tracked track VBN cord-010119-t1x9gknd 6189 26 : : : cord-010119-t1x9gknd 6189 27 sample sample NN cord-010119-t1x9gknd 6189 28 sort sort NN cord-010119-t1x9gknd 6189 29 and and CC cord-010119-t1x9gknd 6189 30 loading loading NN cord-010119-t1x9gknd 6189 31 , , , cord-010119-t1x9gknd 6189 32 routine routine JJ cord-010119-t1x9gknd 6189 33 testing testing NN cord-010119-t1x9gknd 6189 34 , , , cord-010119-t1x9gknd 6189 35 post post JJ cord-010119-t1x9gknd 6189 36 - - JJ cord-010119-t1x9gknd 6189 37 run run JJ cord-010119-t1x9gknd 6189 38 procedures procedure NNS cord-010119-t1x9gknd 6189 39 , , , cord-010119-t1x9gknd 6189 40 consumables consumable NNS cord-010119-t1x9gknd 6189 41 used use VBN cord-010119-t1x9gknd 6189 42 , , , cord-010119-t1x9gknd 6189 43 and and CC cord-010119-t1x9gknd 6189 44 space space NN cord-010119-t1x9gknd 6189 45 requirements requirement NNS cord-010119-t1x9gknd 6189 46 . . . cord-010119-t1x9gknd 6190 1 A a DT cord-010119-t1x9gknd 6190 2 threshold threshold NN cord-010119-t1x9gknd 6190 3 for for IN cord-010119-t1x9gknd 6190 4 in in IN cord-010119-t1x9gknd 6190 5 vitrodetection vitrodetection NN cord-010119-t1x9gknd 6190 6 of of IN cord-010119-t1x9gknd 6190 7 anti anti JJ cord-010119-t1x9gknd 6190 8 - - JJ cord-010119-t1x9gknd 6190 9 D d JJ cord-010119-t1x9gknd 6190 10 gamma gamma NN cord-010119-t1x9gknd 6190 11 globulin globulin NN cord-010119-t1x9gknd 6190 12 was be VBD cord-010119-t1x9gknd 6190 13 also also RB cord-010119-t1x9gknd 6190 14 determined determine VBN cord-010119-t1x9gknd 6190 15 . . . cord-010119-t1x9gknd 6191 1 V v NN cord-010119-t1x9gknd 6191 2 R r NN cord-010119-t1x9gknd 6191 3 Analyzer Analyzer NNP cord-010119-t1x9gknd 6191 4 and and CC cord-010119-t1x9gknd 6191 5 the the DT cord-010119-t1x9gknd 6191 6 reference reference NN cord-010119-t1x9gknd 6191 7 method method NN cord-010119-t1x9gknd 6191 8 were be VBD cord-010119-t1x9gknd 6191 9 obtained obtain VBN cord-010119-t1x9gknd 6191 10 in in IN cord-010119-t1x9gknd 6191 11 99.2 99.2 CD cord-010119-t1x9gknd 6191 12 % % NN cord-010119-t1x9gknd 6191 13 of of IN cord-010119-t1x9gknd 6191 14 the the DT cord-010119-t1x9gknd 6191 15 ABO ABO NNP cord-010119-t1x9gknd 6191 16 / / SYM cord-010119-t1x9gknd 6191 17 D d NN cord-010119-t1x9gknd 6191 18 tests test NNS cord-010119-t1x9gknd 6191 19 ( ( -LRB- cord-010119-t1x9gknd 6191 20 n5265 n5265 NNP cord-010119-t1x9gknd 6191 21 ) ) -RRB- cord-010119-t1x9gknd 6191 22 , , , cord-010119-t1x9gknd 6191 23 99,7 99,7 CD cord-010119-t1x9gknd 6191 24 % % NN cord-010119-t1x9gknd 6191 25 of of IN cord-010119-t1x9gknd 6191 26 the the DT cord-010119-t1x9gknd 6191 27 antibody antibody NN cord-010119-t1x9gknd 6191 28 screening screening NN cord-010119-t1x9gknd 6191 29 tests test NNS cord-010119-t1x9gknd 6191 30 ( ( -LRB- cord-010119-t1x9gknd 6191 31 n5377 n5377 NNP cord-010119-t1x9gknd 6191 32 ) ) -RRB- cord-010119-t1x9gknd 6191 33 , , , cord-010119-t1x9gknd 6191 34 88,8 88,8 CD cord-010119-t1x9gknd 6191 35 % % NN cord-010119-t1x9gknd 6191 36 of of IN cord-010119-t1x9gknd 6191 37 the the DT cord-010119-t1x9gknd 6191 38 antibody antibody NN cord-010119-t1x9gknd 6191 39 identification identification NN cord-010119-t1x9gknd 6191 40 tests test NNS cord-010119-t1x9gknd 6191 41 ( ( -LRB- cord-010119-t1x9gknd 6191 42 n59 n59 NN cord-010119-t1x9gknd 6191 43 ) ) -RRB- cord-010119-t1x9gknd 6191 44 and and CC cord-010119-t1x9gknd 6191 45 100 100 CD cord-010119-t1x9gknd 6191 46 % % NN cord-010119-t1x9gknd 6191 47 of of IN cord-010119-t1x9gknd 6191 48 the the DT cord-010119-t1x9gknd 6191 49 DAT DAT NNP cord-010119-t1x9gknd 6191 50 tests test NNS cord-010119-t1x9gknd 6191 51 ( ( -LRB- cord-010119-t1x9gknd 6191 52 n510 n510 NNP cord-010119-t1x9gknd 6191 53 ) ) -RRB- cord-010119-t1x9gknd 6191 54 . . . cord-010119-t1x9gknd 6192 1 There there EX cord-010119-t1x9gknd 6192 2 were be VBD cord-010119-t1x9gknd 6192 3 4 4 CD cord-010119-t1x9gknd 6192 4 discrepancies discrepancy NNS cord-010119-t1x9gknd 6192 5 ( ( -LRB- cord-010119-t1x9gknd 6192 6 2 2 CD cord-010119-t1x9gknd 6192 7 ABO ABO NNP cord-010119-t1x9gknd 6192 8 / / SYM cord-010119-t1x9gknd 6192 9 D d NN cord-010119-t1x9gknd 6192 10 for for IN cord-010119-t1x9gknd 6192 11 the the DT cord-010119-t1x9gknd 6192 12 same same JJ cord-010119-t1x9gknd 6192 13 patient patient NN cord-010119-t1x9gknd 6192 14 , , , cord-010119-t1x9gknd 6192 15 1 1 CD cord-010119-t1x9gknd 6192 16 for for IN cord-010119-t1x9gknd 6192 17 antibody antibody NN cord-010119-t1x9gknd 6192 18 screening screening NN cord-010119-t1x9gknd 6192 19 and and CC cord-010119-t1x9gknd 6192 20 1 1 CD cord-010119-t1x9gknd 6192 21 antibody antibody NN cord-010119-t1x9gknd 6192 22 identification identification NN cord-010119-t1x9gknd 6192 23 : : : cord-010119-t1x9gknd 6193 1 In in IN cord-010119-t1x9gknd 6193 2 both both DT cord-010119-t1x9gknd 6193 3 cases case NNS cord-010119-t1x9gknd 6193 4 , , , cord-010119-t1x9gknd 6193 5 the the DT cord-010119-t1x9gknd 6193 6 Erytra Erytra NNP cord-010119-t1x9gknd 6193 7 Eflexis Eflexis NNP cord-010119-t1x9gknd 6193 8 V v NN cord-010119-t1x9gknd 6193 9 R r NN cord-010119-t1x9gknd 6193 10 could could MD cord-010119-t1x9gknd 6193 11 conclude conclude VB cord-010119-t1x9gknd 6193 12 whereas whereas IN cord-010119-t1x9gknd 6193 13 Erytra Erytra NNP cord-010119-t1x9gknd 6193 14 could could MD cord-010119-t1x9gknd 6193 15 not not RB cord-010119-t1x9gknd 6193 16 due due IN cord-010119-t1x9gknd 6193 17 to to IN cord-010119-t1x9gknd 6193 18 a a DT cord-010119-t1x9gknd 6193 19 poor poor JJ cord-010119-t1x9gknd 6193 20 reaction reaction NN cord-010119-t1x9gknd 6193 21 . . . cord-010119-t1x9gknd 6194 1 Use use NN cord-010119-t1x9gknd 6194 2 of of IN cord-010119-t1x9gknd 6194 3 the the DT cord-010119-t1x9gknd 6194 4 STAT stat NN cord-010119-t1x9gknd 6194 5 mode mode NN cord-010119-t1x9gknd 6194 6 ( ( -LRB- cord-010119-t1x9gknd 6194 7 incubator incubator NN cord-010119-t1x9gknd 6194 8 is be VBZ cord-010119-t1x9gknd 6194 9 reserved reserve VBN cord-010119-t1x9gknd 6194 10 for for IN cord-010119-t1x9gknd 6194 11 urgent urgent JJ cord-010119-t1x9gknd 6194 12 tests test NNS cord-010119-t1x9gknd 6194 13 ) ) -RRB- cord-010119-t1x9gknd 6194 14 proved prove VBD cord-010119-t1x9gknd 6194 15 its -PRON- PRP$ cord-010119-t1x9gknd 6194 16 usefulness usefulness NN cord-010119-t1x9gknd 6194 17 when when WRB cord-010119-t1x9gknd 6194 18 testing test VBG cord-010119-t1x9gknd 6194 19 several several JJ cord-010119-t1x9gknd 6194 20 samples sample NNS cord-010119-t1x9gknd 6194 21 ( ( -LRB- cord-010119-t1x9gknd 6194 22 time time NN cord-010119-t1x9gknd 6194 23 saving saving NN cord-010119-t1x9gknd 6194 24 was be VBD cord-010119-t1x9gknd 6194 25 more more JJR cord-010119-t1x9gknd 6194 26 than than IN cord-010119-t1x9gknd 6194 27 10 10 CD cord-010119-t1x9gknd 6194 28 min min NN cord-010119-t1x9gknd 6194 29 ) ) -RRB- cord-010119-t1x9gknd 6194 30 . . . cord-010119-t1x9gknd 6195 1 Detection detection NN cord-010119-t1x9gknd 6195 2 threshold threshold NN cord-010119-t1x9gknd 6195 3 of of IN cord-010119-t1x9gknd 6195 4 the the DT cord-010119-t1x9gknd 6195 5 D D NNP cord-010119-t1x9gknd 6195 6 antibody antibody NN cord-010119-t1x9gknd 6195 7 was be VBD cord-010119-t1x9gknd 6195 8 assessed assess VBN cord-010119-t1x9gknd 6195 9 at at IN cord-010119-t1x9gknd 6195 10 2.5 2.5 CD cord-010119-t1x9gknd 6195 11 ng ng NNP cord-010119-t1x9gknd 6195 12 / / SYM cord-010119-t1x9gknd 6195 13 ml ml NN cord-010119-t1x9gknd 6195 14 ( ( -LRB- cord-010119-t1x9gknd 6195 15 0.0125 0.0125 CD cord-010119-t1x9gknd 6195 16 UI UI NNP cord-010119-t1x9gknd 6195 17 / / SYM cord-010119-t1x9gknd 6195 18 ml ml NN cord-010119-t1x9gknd 6195 19 ) ) -RRB- cord-010119-t1x9gknd 6195 20 whereas whereas IN cord-010119-t1x9gknd 6195 21 the the DT cord-010119-t1x9gknd 6195 22 French french JJ cord-010119-t1x9gknd 6195 23 recommendations recommendation NNS cord-010119-t1x9gknd 6195 24 are be VBP cord-010119-t1x9gknd 6195 25 20 20 CD cord-010119-t1x9gknd 6195 26 ng ng NN cord-010119-t1x9gknd 6195 27 / / SYM cord-010119-t1x9gknd 6195 28 ml ml NN cord-010119-t1x9gknd 6195 29 . . . cord-010119-t1x9gknd 6196 1 The the DT cord-010119-t1x9gknd 6196 2 possibility possibility NN cord-010119-t1x9gknd 6196 3 of of IN cord-010119-t1x9gknd 6196 4 interchanging interchange VBG cord-010119-t1x9gknd 6196 5 the the DT cord-010119-t1x9gknd 6196 6 trays tray NNS cord-010119-t1x9gknd 6196 7 ( ( -LRB- cord-010119-t1x9gknd 6196 8 reagents reagent NNS cord-010119-t1x9gknd 6196 9 / / SYM cord-010119-t1x9gknd 6196 10 sample sample NN cord-010119-t1x9gknd 6196 11 ) ) -RRB- cord-010119-t1x9gknd 6196 12 makes make VBZ cord-010119-t1x9gknd 6196 13 also also RB cord-010119-t1x9gknd 6196 14 possible possible JJ cord-010119-t1x9gknd 6196 15 to to TO cord-010119-t1x9gknd 6196 16 optimize optimize VB cord-010119-t1x9gknd 6196 17 the the DT cord-010119-t1x9gknd 6196 18 analyzer analyzer NN cord-010119-t1x9gknd 6196 19 operation operation NN cord-010119-t1x9gknd 6196 20 . . . cord-010119-t1x9gknd 6197 1 The the DT cord-010119-t1x9gknd 6197 2 impressions impression NNS cord-010119-t1x9gknd 6197 3 of of IN cord-010119-t1x9gknd 6197 4 the the DT cord-010119-t1x9gknd 6197 5 technical technical JJ cord-010119-t1x9gknd 6197 6 staff staff NN cord-010119-t1x9gknd 6197 7 were be VBD cord-010119-t1x9gknd 6197 8 positive positive JJ cord-010119-t1x9gknd 6197 9 regarding regard VBG cord-010119-t1x9gknd 6197 10 esthetic esthetic JJ cord-010119-t1x9gknd 6197 11 and and CC cord-010119-t1x9gknd 6197 12 functional functional JJ cord-010119-t1x9gknd 6197 13 design design NN cord-010119-t1x9gknd 6197 14 , , , cord-010119-t1x9gknd 6197 15 intuitive intuitive JJ cord-010119-t1x9gknd 6197 16 and and CC cord-010119-t1x9gknd 6197 17 easy easy JJ cord-010119-t1x9gknd 6197 18 use use NN cord-010119-t1x9gknd 6197 19 , , , cord-010119-t1x9gknd 6197 20 as as RB cord-010119-t1x9gknd 6197 21 well well RB cord-010119-t1x9gknd 6197 22 as as IN cord-010119-t1x9gknd 6197 23 flexibility flexibility NN cord-010119-t1x9gknd 6197 24 . . . cord-010119-t1x9gknd 6198 1 V V NNP cord-010119-t1x9gknd 6198 2 R r NN cord-010119-t1x9gknd 6198 3 results result NNS cord-010119-t1x9gknd 6198 4 demonstrated demonstrate VBD cord-010119-t1x9gknd 6198 5 velocity velocity NN cord-010119-t1x9gknd 6198 6 , , , cord-010119-t1x9gknd 6198 7 sensitivity sensitivity NN cord-010119-t1x9gknd 6198 8 , , , cord-010119-t1x9gknd 6198 9 as as RB cord-010119-t1x9gknd 6198 10 well well RB cord-010119-t1x9gknd 6198 11 as as IN cord-010119-t1x9gknd 6198 12 the the DT cord-010119-t1x9gknd 6198 13 ability ability NN cord-010119-t1x9gknd 6198 14 to to TO cord-010119-t1x9gknd 6198 15 easily easily RB cord-010119-t1x9gknd 6198 16 perform perform VB cord-010119-t1x9gknd 6198 17 the the DT cord-010119-t1x9gknd 6198 18 routine routine JJ cord-010119-t1x9gknd 6198 19 workload workload NN cord-010119-t1x9gknd 6198 20 of of IN cord-010119-t1x9gknd 6198 21 a a DT cord-010119-t1x9gknd 6198 22 medical medical JJ cord-010119-t1x9gknd 6198 23 analysis analysis NN cord-010119-t1x9gknd 6198 24 laboratory laboratory NN cord-010119-t1x9gknd 6198 25 . . . cord-010119-t1x9gknd 6199 1 Erytra Erytra NNP cord-010119-t1x9gknd 6200 1 Eflexis Eflexis NNP cord-010119-t1x9gknd 6200 2 V v NN cord-010119-t1x9gknd 6200 3 R r NN cord-010119-t1x9gknd 6200 4 meets meet VBZ cord-010119-t1x9gknd 6200 5 both both CC cord-010119-t1x9gknd 6200 6 the the DT cord-010119-t1x9gknd 6200 7 requirements requirement NNS cord-010119-t1x9gknd 6200 8 for for IN cord-010119-t1x9gknd 6200 9 French french JJ cord-010119-t1x9gknd 6200 10 regulatory regulatory JJ cord-010119-t1x9gknd 6200 11 in in IN cord-010119-t1x9gknd 6200 12 immunohematology immunohematology NN cord-010119-t1x9gknd 6200 13 and and CC cord-010119-t1x9gknd 6200 14 for for IN cord-010119-t1x9gknd 6200 15 ISO iso NN cord-010119-t1x9gknd 6200 16 15189 15189 CD cord-010119-t1x9gknd 6200 17 accreditation accreditation NN cord-010119-t1x9gknd 6200 18 . . . cord-010119-t1x9gknd 6201 1 Background Background NNP cord-010119-t1x9gknd 6201 2 / / SYM cord-010119-t1x9gknd 6201 3 Case Case NNP cord-010119-t1x9gknd 6201 4 Studies Studies NNPS cord-010119-t1x9gknd 6201 5 : : : cord-010119-t1x9gknd 6202 1 Kell Kell NNP cord-010119-t1x9gknd 6202 2 system system NN cord-010119-t1x9gknd 6202 3 antibodies antibody NNS cord-010119-t1x9gknd 6202 4 inhibit inhibit VBP cord-010119-t1x9gknd 6202 5 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 6202 6 causing cause VBG cord-010119-t1x9gknd 6202 7 severe severe JJ cord-010119-t1x9gknd 6202 8 anemia anemia NN cord-010119-t1x9gknd 6202 9 in in IN cord-010119-t1x9gknd 6202 10 hemolytic hemolytic JJ cord-010119-t1x9gknd 6202 11 disease disease NN cord-010119-t1x9gknd 6202 12 of of IN cord-010119-t1x9gknd 6202 13 the the DT cord-010119-t1x9gknd 6202 14 fetus fetus NN cord-010119-t1x9gknd 6202 15 and and CC cord-010119-t1x9gknd 6202 16 newborn newborn JJ cord-010119-t1x9gknd 6202 17 ( ( -LRB- cord-010119-t1x9gknd 6202 18 HDFN HDFN NNP cord-010119-t1x9gknd 6202 19 ) ) -RRB- cord-010119-t1x9gknd 6202 20 . . . cord-010119-t1x9gknd 6203 1 We -PRON- PRP cord-010119-t1x9gknd 6203 2 report report VBP cord-010119-t1x9gknd 6203 3 a a DT cord-010119-t1x9gknd 6203 4 case case NN cord-010119-t1x9gknd 6203 5 of of IN cord-010119-t1x9gknd 6203 6 HDFN HDFN NNP cord-010119-t1x9gknd 6203 7 secondary secondary JJ cord-010119-t1x9gknd 6203 8 to to IN cord-010119-t1x9gknd 6203 9 anti anti JJ cord-010119-t1x9gknd 6203 10 - - JJ cord-010119-t1x9gknd 6203 11 Kpb kpb JJ cord-010119-t1x9gknd 6203 12 that that WDT cord-010119-t1x9gknd 6203 13 resulted result VBD cord-010119-t1x9gknd 6203 14 in in IN cord-010119-t1x9gknd 6203 15 multiple multiple JJ cord-010119-t1x9gknd 6203 16 intrauterine intrauterine JJ cord-010119-t1x9gknd 6203 17 transfusions transfusion NNS cord-010119-t1x9gknd 6203 18 of of IN cord-010119-t1x9gknd 6203 19 Kp Kp NNP cord-010119-t1x9gknd 6203 20 ( ( -LRB- cord-010119-t1x9gknd 6203 21 b- b- NN cord-010119-t1x9gknd 6203 22 ) ) -RRB- cord-010119-t1x9gknd 6203 23 donor donor NN cord-010119-t1x9gknd 6203 24 cells cell NNS cord-010119-t1x9gknd 6203 25 and and CC cord-010119-t1x9gknd 6203 26 hemolytic hemolytic JJ cord-010119-t1x9gknd 6203 27 anemia anemia NN cord-010119-t1x9gknd 6203 28 upon upon IN cord-010119-t1x9gknd 6203 29 birth birth NN cord-010119-t1x9gknd 6203 30 . . . cord-010119-t1x9gknd 6204 1 Case case NN cord-010119-t1x9gknd 6204 2 : : : cord-010119-t1x9gknd 6205 1 A a DT cord-010119-t1x9gknd 6205 2 31 31 CD cord-010119-t1x9gknd 6205 3 year year NN cord-010119-t1x9gknd 6205 4 old old JJ cord-010119-t1x9gknd 6205 5 G5P3 G5P3 NNP cord-010119-t1x9gknd 6205 6 presented present VBD cord-010119-t1x9gknd 6205 7 during during IN cord-010119-t1x9gknd 6205 8 her -PRON- PRP$ cord-010119-t1x9gknd 6205 9 fifth fifth JJ cord-010119-t1x9gknd 6205 10 pregnancy pregnancy NN cord-010119-t1x9gknd 6205 11 with with IN cord-010119-t1x9gknd 6205 12 anti anti JJ cord-010119-t1x9gknd 6205 13 - - JJ cord-010119-t1x9gknd 6205 14 Kpb kpb JJ cord-010119-t1x9gknd 6205 15 with with IN cord-010119-t1x9gknd 6205 16 an an DT cord-010119-t1x9gknd 6205 17 initial initial JJ cord-010119-t1x9gknd 6205 18 titer titer NN cord-010119-t1x9gknd 6205 19 measured measure VBN cord-010119-t1x9gknd 6205 20 of of IN cord-010119-t1x9gknd 6205 21 64 64 CD cord-010119-t1x9gknd 6205 22 . . . cord-010119-t1x9gknd 6206 1 By by IN cord-010119-t1x9gknd 6206 2 history history NN cord-010119-t1x9gknd 6206 3 , , , cord-010119-t1x9gknd 6206 4 the the DT cord-010119-t1x9gknd 6206 5 anti anti JJ cord-010119-t1x9gknd 6206 6 - - JJ cord-010119-t1x9gknd 6206 7 Kpb Kpb NNP cord-010119-t1x9gknd 6206 8 developed develop VBN cord-010119-t1x9gknd 6206 9 during during IN cord-010119-t1x9gknd 6206 10 her -PRON- PRP$ cord-010119-t1x9gknd 6206 11 third third JJ cord-010119-t1x9gknd 6206 12 pregnancy pregnancy NN cord-010119-t1x9gknd 6206 13 which which WDT cord-010119-t1x9gknd 6206 14 ended end VBD cord-010119-t1x9gknd 6206 15 in in IN cord-010119-t1x9gknd 6206 16 a a DT cord-010119-t1x9gknd 6206 17 spontaneous spontaneous JJ cord-010119-t1x9gknd 6206 18 abortion abortion NN cord-010119-t1x9gknd 6206 19 before before IN cord-010119-t1x9gknd 6206 20 antibody antibody NN cord-010119-t1x9gknd 6206 21 titers titer NNS cord-010119-t1x9gknd 6206 22 could could MD cord-010119-t1x9gknd 6206 23 be be VB cord-010119-t1x9gknd 6206 24 initiated initiate VBN cord-010119-t1x9gknd 6206 25 . . . cord-010119-t1x9gknd 6207 1 The the DT cord-010119-t1x9gknd 6207 2 patient patient NN cord-010119-t1x9gknd 6207 3 's 's POS cord-010119-t1x9gknd 6207 4 antibody antibody NN cord-010119-t1x9gknd 6207 5 titers titer NNS cord-010119-t1x9gknd 6207 6 peaked peak VBD cord-010119-t1x9gknd 6207 7 at at IN cord-010119-t1x9gknd 6207 8 16 16 CD cord-010119-t1x9gknd 6207 9 during during IN cord-010119-t1x9gknd 6207 10 the the DT cord-010119-t1x9gknd 6207 11 fourth fourth JJ cord-010119-t1x9gknd 6207 12 pregnancy pregnancy NN cord-010119-t1x9gknd 6207 13 which which WDT cord-010119-t1x9gknd 6207 14 resulted result VBD cord-010119-t1x9gknd 6207 15 in in IN cord-010119-t1x9gknd 6207 16 a a DT cord-010119-t1x9gknd 6207 17 healthy healthy JJ cord-010119-t1x9gknd 6207 18 male male NN cord-010119-t1x9gknd 6207 19 without without IN cord-010119-t1x9gknd 6207 20 anemia anemia NN cord-010119-t1x9gknd 6207 21 or or CC cord-010119-t1x9gknd 6207 22 jaundice jaundice NN cord-010119-t1x9gknd 6207 23 . . . cord-010119-t1x9gknd 6207 24 . . . cord-010119-t1x9gknd 6208 1 In in IN cord-010119-t1x9gknd 6208 2 the the DT cord-010119-t1x9gknd 6208 3 latest late JJS cord-010119-t1x9gknd 6208 4 pregnancy pregnancy NN cord-010119-t1x9gknd 6208 5 , , , cord-010119-t1x9gknd 6208 6 ultrasound ultrasound NN cord-010119-t1x9gknd 6208 7 was be VBD cord-010119-t1x9gknd 6208 8 initiated initiate VBN cord-010119-t1x9gknd 6208 9 with with IN cord-010119-t1x9gknd 6208 10 elevated elevated JJ cord-010119-t1x9gknd 6208 11 middle middle JJ cord-010119-t1x9gknd 6208 12 cerebral cerebral JJ cord-010119-t1x9gknd 6208 13 artery artery NN cord-010119-t1x9gknd 6208 14 Doppler Doppler NNP cord-010119-t1x9gknd 6208 15 exams exam NNS cord-010119-t1x9gknd 6208 16 ( ( -LRB- cord-010119-t1x9gknd 6208 17 1.7 1.7 CD cord-010119-t1x9gknd 6208 18 MoMs MoMs NNP cord-010119-t1x9gknd 6208 19 ) ) -RRB- cord-010119-t1x9gknd 6208 20 peaking peak VBG cord-010119-t1x9gknd 6208 21 at at IN cord-010119-t1x9gknd 6208 22 27 27 CD cord-010119-t1x9gknd 6208 23 weeks week NNS cord-010119-t1x9gknd 6208 24 . . . cord-010119-t1x9gknd 6209 1 This this DT cord-010119-t1x9gknd 6209 2 resulted result VBD cord-010119-t1x9gknd 6209 3 in in IN cord-010119-t1x9gknd 6209 4 three three CD cord-010119-t1x9gknd 6209 5 intrauterine intrauterine JJ cord-010119-t1x9gknd 6209 6 transfusions transfusion NNS cord-010119-t1x9gknd 6209 7 . . . cord-010119-t1x9gknd 6210 1 Due due IN cord-010119-t1x9gknd 6210 2 to to IN cord-010119-t1x9gknd 6210 3 potential potential JJ cord-010119-t1x9gknd 6210 4 labor labor NN cord-010119-t1x9gknd 6210 5 and and CC cord-010119-t1x9gknd 6210 6 the the DT cord-010119-t1x9gknd 6210 7 finding finding NN cord-010119-t1x9gknd 6210 8 of of IN cord-010119-t1x9gknd 6210 9 reversed reverse VBN cord-010119-t1x9gknd 6210 10 diastolic diastolic JJ cord-010119-t1x9gknd 6210 11 flow flow NN cord-010119-t1x9gknd 6210 12 on on IN cord-010119-t1x9gknd 6210 13 middle middle JJ cord-010119-t1x9gknd 6210 14 cerebral cerebral JJ cord-010119-t1x9gknd 6210 15 artery artery NN cord-010119-t1x9gknd 6210 16 Doppler Doppler NNP cord-010119-t1x9gknd 6210 17 studies study NNS cord-010119-t1x9gknd 6210 18 , , , cord-010119-t1x9gknd 6210 19 a a DT cord-010119-t1x9gknd 6210 20 finding finding NN cord-010119-t1x9gknd 6210 21 that that WDT cord-010119-t1x9gknd 6210 22 has have VBZ cord-010119-t1x9gknd 6210 23 been be VBN cord-010119-t1x9gknd 6210 24 associated associate VBN cord-010119-t1x9gknd 6210 25 with with IN cord-010119-t1x9gknd 6210 26 impending impend VBG cord-010119-t1x9gknd 6210 27 intrauterine intrauterine JJ cord-010119-t1x9gknd 6210 28 fetal fetal JJ cord-010119-t1x9gknd 6210 29 demise demise NN cord-010119-t1x9gknd 6210 30 , , , cord-010119-t1x9gknd 6210 31 Caesarean caesarean JJ cord-010119-t1x9gknd 6210 32 delivery delivery NN cord-010119-t1x9gknd 6210 33 was be VBD cord-010119-t1x9gknd 6210 34 performed perform VBN cord-010119-t1x9gknd 6210 35 at at IN cord-010119-t1x9gknd 6210 36 35 35 CD cord-010119-t1x9gknd 6210 37 weeks week NNS cord-010119-t1x9gknd 6210 38 gestation gestation NN cord-010119-t1x9gknd 6210 39 . . . cord-010119-t1x9gknd 6211 1 The the DT cord-010119-t1x9gknd 6211 2 baby baby NN cord-010119-t1x9gknd 6211 3 boy boy NN cord-010119-t1x9gknd 6211 4 required require VBD cord-010119-t1x9gknd 6211 5 phototherapy phototherapy NN cord-010119-t1x9gknd 6211 6 for for IN cord-010119-t1x9gknd 6211 7 hyperbilirubinemia hyperbilirubinemia NNP cord-010119-t1x9gknd 6211 8 . . . cord-010119-t1x9gknd 6212 1 The the DT cord-010119-t1x9gknd 6212 2 indirect indirect JJ cord-010119-t1x9gknd 6212 3 bilirubin bilirubin NN cord-010119-t1x9gknd 6212 4 at at IN cord-010119-t1x9gknd 6212 5 birth birth NN cord-010119-t1x9gknd 6212 6 was be VBD cord-010119-t1x9gknd 6213 1 3.4 3.4 CD cord-010119-t1x9gknd 6213 2 mg mg NN cord-010119-t1x9gknd 6213 3 / / SYM cord-010119-t1x9gknd 6213 4 dL dL NNP cord-010119-t1x9gknd 6213 5 with with IN cord-010119-t1x9gknd 6213 6 13.6 13.6 CD cord-010119-t1x9gknd 6213 7 g g NN cord-010119-t1x9gknd 6213 8 / / SYM cord-010119-t1x9gknd 6213 9 dL dl NN cord-010119-t1x9gknd 6213 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 6213 11 . . . cord-010119-t1x9gknd 6214 1 The the DT cord-010119-t1x9gknd 6214 2 baby baby NN cord-010119-t1x9gknd 6214 3 typed type VBD cord-010119-t1x9gknd 6214 4 as as IN cord-010119-t1x9gknd 6214 5 O O NNP cord-010119-t1x9gknd 6214 6 Positive Positive NNP cord-010119-t1x9gknd 6214 7 , , , cord-010119-t1x9gknd 6214 8 Kp Kp NNP cord-010119-t1x9gknd 6214 9 ( ( -LRB- cord-010119-t1x9gknd 6214 10 b1 b1 NNP cord-010119-t1x9gknd 6214 11 ) ) -RRB- cord-010119-t1x9gknd 6214 12 with with IN cord-010119-t1x9gknd 6214 13 a a DT cord-010119-t1x9gknd 6214 14 micro micro JJ cord-010119-t1x9gknd 6214 15 positive positive JJ cord-010119-t1x9gknd 6214 16 DAT dat NN cord-010119-t1x9gknd 6214 17 . . . cord-010119-t1x9gknd 6215 1 The the DT cord-010119-t1x9gknd 6215 2 antibody antibody NN cord-010119-t1x9gknd 6215 3 workup workup NN cord-010119-t1x9gknd 6215 4 revealed reveal VBD cord-010119-t1x9gknd 6215 5 an an DT cord-010119-t1x9gknd 6215 6 anti anti JJ cord-010119-t1x9gknd 6215 7 - - JJ cord-010119-t1x9gknd 6215 8 Kpb kpb JJ cord-010119-t1x9gknd 6215 9 . . . cord-010119-t1x9gknd 6216 1 Continued continued JJ cord-010119-t1x9gknd 6216 2 hemolysis hemolysis NN cord-010119-t1x9gknd 6216 3 required require VBD cord-010119-t1x9gknd 6216 4 one one CD cord-010119-t1x9gknd 6216 5 more more JJR cord-010119-t1x9gknd 6216 6 transfusion transfusion NN cord-010119-t1x9gknd 6216 7 at at IN cord-010119-t1x9gknd 6216 8 6 6 CD cord-010119-t1x9gknd 6216 9 weeks week NNS cord-010119-t1x9gknd 6216 10 of of IN cord-010119-t1x9gknd 6216 11 age age NN cord-010119-t1x9gknd 6216 12 . . . cord-010119-t1x9gknd 6217 1 The the DT cord-010119-t1x9gknd 6217 2 positive positive JJ cord-010119-t1x9gknd 6217 3 DAT dat NN cord-010119-t1x9gknd 6217 4 and and CC cord-010119-t1x9gknd 6217 5 passively passively RB cord-010119-t1x9gknd 6217 6 acquired acquire VBD cord-010119-t1x9gknd 6217 7 anti anti JJ cord-010119-t1x9gknd 6217 8 - - NNP cord-010119-t1x9gknd 6217 9 Kpb Kpb NNP cord-010119-t1x9gknd 6217 10 were be VBD cord-010119-t1x9gknd 6217 11 no no RB cord-010119-t1x9gknd 6217 12 longer long RBR cord-010119-t1x9gknd 6217 13 detected detect VBN cord-010119-t1x9gknd 6217 14 by by IN cord-010119-t1x9gknd 6217 15 8 8 CD cord-010119-t1x9gknd 6217 16 weeks week NNS cord-010119-t1x9gknd 6217 17 of of IN cord-010119-t1x9gknd 6217 18 age age NN cord-010119-t1x9gknd 6217 19 . . . cord-010119-t1x9gknd 6218 1 His -PRON- PRP$ cord-010119-t1x9gknd 6218 2 hemoglobin hemoglobin NN cord-010119-t1x9gknd 6218 3 recovered recover VBD cord-010119-t1x9gknd 6218 4 to to IN cord-010119-t1x9gknd 6218 5 9.0 9.0 CD cord-010119-t1x9gknd 6218 6 g g NN cord-010119-t1x9gknd 6218 7 / / SYM cord-010119-t1x9gknd 6218 8 dL dl NN cord-010119-t1x9gknd 6218 9 with with IN cord-010119-t1x9gknd 6218 10 an an DT cord-010119-t1x9gknd 6218 11 indirect indirect JJ cord-010119-t1x9gknd 6218 12 bilirubin bilirubin NN cord-010119-t1x9gknd 6218 13 of of IN cord-010119-t1x9gknd 6218 14 1.4 1.4 CD cord-010119-t1x9gknd 6218 15 mg mg NNP cord-010119-t1x9gknd 6218 16 / / SYM cord-010119-t1x9gknd 6218 17 dL dl NN cord-010119-t1x9gknd 6218 18 at at IN cord-010119-t1x9gknd 6218 19 9 9 CD cord-010119-t1x9gknd 6218 20 weeks week NNS cord-010119-t1x9gknd 6218 21 of of IN cord-010119-t1x9gknd 6218 22 age age NN cord-010119-t1x9gknd 6218 23 . . . cord-010119-t1x9gknd 6219 1 All all DT cord-010119-t1x9gknd 6219 2 clinical clinical JJ cord-010119-t1x9gknd 6219 3 signs sign NNS cord-010119-t1x9gknd 6219 4 of of IN cord-010119-t1x9gknd 6219 5 hemolytic hemolytic JJ cord-010119-t1x9gknd 6219 6 anemia anemia NN cord-010119-t1x9gknd 6219 7 were be VBD cord-010119-t1x9gknd 6219 8 resolved resolve VBN cord-010119-t1x9gknd 6219 9 . . . cord-010119-t1x9gknd 6220 1 Study Study NNP cord-010119-t1x9gknd 6220 2 Design Design NNP cord-010119-t1x9gknd 6220 3 / / SYM cord-010119-t1x9gknd 6220 4 Method method NN cord-010119-t1x9gknd 6220 5 : : : cord-010119-t1x9gknd 6221 1 Serologic Serologic NNP cord-010119-t1x9gknd 6221 2 testing testing NN cord-010119-t1x9gknd 6221 3 included include VBD cord-010119-t1x9gknd 6221 4 PEG PEG NNP cord-010119-t1x9gknd 6221 5 IAT IAT NNP cord-010119-t1x9gknd 6221 6 by by IN cord-010119-t1x9gknd 6221 7 tube tube NN cord-010119-t1x9gknd 6221 8 methods method NNS cord-010119-t1x9gknd 6221 9 . . . cord-010119-t1x9gknd 6222 1 Acid acid NN cord-010119-t1x9gknd 6222 2 elution elution NN cord-010119-t1x9gknd 6222 3 was be VBD cord-010119-t1x9gknd 6222 4 performed perform VBN cord-010119-t1x9gknd 6222 5 using use VBG cord-010119-t1x9gknd 6222 6 Immucor Immucor NNP cord-010119-t1x9gknd 6222 7 Gamma Gamma NNP cord-010119-t1x9gknd 6222 8 ELU ELU NNP cord-010119-t1x9gknd 6222 9 - - HYPH cord-010119-t1x9gknd 6222 10 KIT KIT NNP cord-010119-t1x9gknd 6222 11 II II NNP cord-010119-t1x9gknd 6222 12 . . . cord-010119-t1x9gknd 6223 1 Molecular molecular JJ cord-010119-t1x9gknd 6223 2 testing testing NN cord-010119-t1x9gknd 6223 3 was be VBD cord-010119-t1x9gknd 6223 4 performed perform VBN cord-010119-t1x9gknd 6223 5 using use VBG cord-010119-t1x9gknd 6223 6 Immucor Immucor NNP cord-010119-t1x9gknd 6223 7 Bio Bio NNP cord-010119-t1x9gknd 6223 8 - - HYPH cord-010119-t1x9gknd 6223 9 Array Array NNP cord-010119-t1x9gknd 6223 10 HEA HEA NNP cord-010119-t1x9gknd 6223 11 platform platform NN cord-010119-t1x9gknd 6223 12 . . . cord-010119-t1x9gknd 6224 1 Results result NNS cord-010119-t1x9gknd 6224 2 / / SYM cord-010119-t1x9gknd 6224 3 Finding finding NN cord-010119-t1x9gknd 6224 4 : : : cord-010119-t1x9gknd 6225 1 Antibody antibody NN cord-010119-t1x9gknd 6225 2 identification identification NN cord-010119-t1x9gknd 6225 3 on on IN cord-010119-t1x9gknd 6225 4 the the DT cord-010119-t1x9gknd 6225 5 mother mother NN cord-010119-t1x9gknd 6225 6 was be VBD cord-010119-t1x9gknd 6225 7 performed perform VBN cord-010119-t1x9gknd 6225 8 as as RB cord-010119-t1x9gknd 6225 9 well well RB cord-010119-t1x9gknd 6225 10 as as IN cord-010119-t1x9gknd 6225 11 alloadsorption alloadsorption NN cord-010119-t1x9gknd 6225 12 studies study NNS cord-010119-t1x9gknd 6225 13 to to TO cord-010119-t1x9gknd 6225 14 rule rule VB cord-010119-t1x9gknd 6225 15 out out RP cord-010119-t1x9gknd 6225 16 other other JJ cord-010119-t1x9gknd 6225 17 underlying underlie VBG cord-010119-t1x9gknd 6225 18 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6225 19 . . . cord-010119-t1x9gknd 6226 1 A a DT cord-010119-t1x9gknd 6226 2 new new JJ cord-010119-t1x9gknd 6226 3 weakly weakly RB cord-010119-t1x9gknd 6226 4 reacting react VBG cord-010119-t1x9gknd 6226 5 anti anti NNP cord-010119-t1x9gknd 6226 6 - - NNP cord-010119-t1x9gknd 6226 7 S S NNP cord-010119-t1x9gknd 6226 8 was be VBD cord-010119-t1x9gknd 6226 9 detected detect VBN cord-010119-t1x9gknd 6226 10 on on IN cord-010119-t1x9gknd 6226 11 the the DT cord-010119-t1x9gknd 6226 12 day day NN cord-010119-t1x9gknd 6226 13 of of IN cord-010119-t1x9gknd 6226 14 the the DT cord-010119-t1x9gknd 6226 15 delivery delivery NN cord-010119-t1x9gknd 6226 16 . . . cord-010119-t1x9gknd 6227 1 The the DT cord-010119-t1x9gknd 6227 2 baby baby NN cord-010119-t1x9gknd 6227 3 typed type VBD cord-010119-t1x9gknd 6227 4 as as IN cord-010119-t1x9gknd 6227 5 S S NNP cord-010119-t1x9gknd 6227 6 positive positive JJ cord-010119-t1x9gknd 6227 7 however however RB cord-010119-t1x9gknd 6227 8 the the DT cord-010119-t1x9gknd 6227 9 anti anti NNP cord-010119-t1x9gknd 6227 10 - - NNP cord-010119-t1x9gknd 6227 11 S S NNP cord-010119-t1x9gknd 6227 12 was be VBD cord-010119-t1x9gknd 6227 13 not not RB cord-010119-t1x9gknd 6227 14 detected detect VBN cord-010119-t1x9gknd 6227 15 in in IN cord-010119-t1x9gknd 6227 16 an an DT cord-010119-t1x9gknd 6227 17 eluate eluate NN cord-010119-t1x9gknd 6227 18 prepared prepare VBN cord-010119-t1x9gknd 6227 19 from from IN cord-010119-t1x9gknd 6227 20 the the DT cord-010119-t1x9gknd 6227 21 baby baby NN cord-010119-t1x9gknd 6227 22 's 's POS cord-010119-t1x9gknd 6227 23 red red JJ cord-010119-t1x9gknd 6227 24 cells cell NNS cord-010119-t1x9gknd 6227 25 . . . cord-010119-t1x9gknd 6228 1 All all DT cord-010119-t1x9gknd 6228 2 of of IN cord-010119-t1x9gknd 6228 3 the the DT cord-010119-t1x9gknd 6228 4 intrauterine intrauterine JJ cord-010119-t1x9gknd 6228 5 transfusion transfusion NN cord-010119-t1x9gknd 6228 6 units unit NNS cord-010119-t1x9gknd 6228 7 were be VBD cord-010119-t1x9gknd 6228 8 S S NNP cord-010119-t1x9gknd 6228 9 negative negative JJ cord-010119-t1x9gknd 6228 10 . . . cord-010119-t1x9gknd 6229 1 Conclusion conclusion NN cord-010119-t1x9gknd 6229 2 : : : cord-010119-t1x9gknd 6230 1 To to IN cord-010119-t1x9gknd 6230 2 our -PRON- PRP$ cord-010119-t1x9gknd 6230 3 knowledge knowledge NN cord-010119-t1x9gknd 6230 4 only only RB cord-010119-t1x9gknd 6230 5 five five CD cord-010119-t1x9gknd 6230 6 case case NN cord-010119-t1x9gknd 6230 7 reports report NNS cord-010119-t1x9gknd 6230 8 have have VBP cord-010119-t1x9gknd 6230 9 been be VBN cord-010119-t1x9gknd 6230 10 described describe VBN cord-010119-t1x9gknd 6230 11 for for IN cord-010119-t1x9gknd 6230 12 anti anti JJ cord-010119-t1x9gknd 6230 13 - - JJ cord-010119-t1x9gknd 6230 14 Kpb Kpb NNP cord-010119-t1x9gknd 6230 15 which which WDT cord-010119-t1x9gknd 6230 16 resulted result VBD cord-010119-t1x9gknd 6230 17 in in IN cord-010119-t1x9gknd 6230 18 moderate moderate JJ cord-010119-t1x9gknd 6230 19 to to TO cord-010119-t1x9gknd 6230 20 severe severe JJ cord-010119-t1x9gknd 6230 21 HDFN HDFN NNP cord-010119-t1x9gknd 6230 22 . . . cord-010119-t1x9gknd 6231 1 Pregnant pregnant JJ cord-010119-t1x9gknd 6231 2 mothers mother NNS cord-010119-t1x9gknd 6231 3 with with IN cord-010119-t1x9gknd 6231 4 anti anti JJ cord-010119-t1x9gknd 6231 5 - - JJ cord-010119-t1x9gknd 6231 6 Kpb kpb JJ cord-010119-t1x9gknd 6231 7 detected detect VBN cord-010119-t1x9gknd 6231 8 should should MD cord-010119-t1x9gknd 6231 9 be be VB cord-010119-t1x9gknd 6231 10 monitored monitor VBN cord-010119-t1x9gknd 6231 11 closely closely RB cord-010119-t1x9gknd 6231 12 . . . cord-010119-t1x9gknd 6232 1 Background Background NNP cord-010119-t1x9gknd 6232 2 / / SYM cord-010119-t1x9gknd 6232 3 Case Case NNP cord-010119-t1x9gknd 6232 4 Studies Studies NNPS cord-010119-t1x9gknd 6232 5 : : : cord-010119-t1x9gknd 6232 6 In in IN cord-010119-t1x9gknd 6232 7 some some DT cord-010119-t1x9gknd 6232 8 clinical clinical JJ cord-010119-t1x9gknd 6232 9 cases case NNS cord-010119-t1x9gknd 6232 10 , , , cord-010119-t1x9gknd 6232 11 the the DT cord-010119-t1x9gknd 6232 12 C3d C3d NNP cord-010119-t1x9gknd 6232 13 - - HYPH cord-010119-t1x9gknd 6232 14 specific specific JJ cord-010119-t1x9gknd 6232 15 DAT DAT NNP cord-010119-t1x9gknd 6232 16 may may MD cord-010119-t1x9gknd 6232 17 be be VB cord-010119-t1x9gknd 6232 18 too too RB cord-010119-t1x9gknd 6232 19 insensitive insensitive JJ cord-010119-t1x9gknd 6232 20 to to TO cord-010119-t1x9gknd 6232 21 detect detect VB cord-010119-t1x9gknd 6232 22 low low NN cord-010119-t1x9gknd 6232 23 , , , cord-010119-t1x9gknd 6232 24 but but CC cord-010119-t1x9gknd 6232 25 significant significant JJ cord-010119-t1x9gknd 6232 26 levels level NNS cord-010119-t1x9gknd 6232 27 of of IN cord-010119-t1x9gknd 6232 28 C3d C3d NNP cord-010119-t1x9gknd 6232 29 , , , cord-010119-t1x9gknd 6232 30 or or CC cord-010119-t1x9gknd 6232 31 it -PRON- PRP cord-010119-t1x9gknd 6232 32 may may MD cord-010119-t1x9gknd 6232 33 be be VB cord-010119-t1x9gknd 6232 34 inconclusive inconclusive JJ cord-010119-t1x9gknd 6232 35 due due IN cord-010119-t1x9gknd 6232 36 to to IN cord-010119-t1x9gknd 6232 37 spontaneous spontaneous JJ cord-010119-t1x9gknd 6232 38 red red JJ cord-010119-t1x9gknd 6232 39 cell cell NN cord-010119-t1x9gknd 6232 40 ( ( -LRB- cord-010119-t1x9gknd 6232 41 RBC RBC NNP cord-010119-t1x9gknd 6232 42 ) ) -RRB- cord-010119-t1x9gknd 6232 43 aggregation aggregation NN cord-010119-t1x9gknd 6232 44 . . . cord-010119-t1x9gknd 6233 1 Further further RB cord-010119-t1x9gknd 6233 2 , , , cord-010119-t1x9gknd 6233 3 the the DT cord-010119-t1x9gknd 6233 4 DAT DAT NNP cord-010119-t1x9gknd 6233 5 is be VBZ cord-010119-t1x9gknd 6233 6 not not RB cord-010119-t1x9gknd 6233 7 well well RB cord-010119-t1x9gknd 6233 8 suited suited JJ cord-010119-t1x9gknd 6233 9 to to TO cord-010119-t1x9gknd 6233 10 quantify quantify VB cord-010119-t1x9gknd 6233 11 the the DT cord-010119-t1x9gknd 6233 12 number number NN cord-010119-t1x9gknd 6233 13 of of IN cord-010119-t1x9gknd 6233 14 immunoprotein immunoprotein JJ cord-010119-t1x9gknd 6233 15 molecules molecule NNS cord-010119-t1x9gknd 6233 16 on on IN cord-010119-t1x9gknd 6233 17 RBCs rbc NNS cord-010119-t1x9gknd 6233 18 , , , cord-010119-t1x9gknd 6233 19 since since IN cord-010119-t1x9gknd 6233 20 a a DT cord-010119-t1x9gknd 6233 21 " " `` cord-010119-t1x9gknd 6233 22 1111 1111 CD cord-010119-t1x9gknd 6233 23 " " '' cord-010119-t1x9gknd 6233 24 reaction reaction NN cord-010119-t1x9gknd 6233 25 corresponds correspond VBZ cord-010119-t1x9gknd 6233 26 to to IN cord-010119-t1x9gknd 6233 27 about about RB cord-010119-t1x9gknd 6233 28 500 500 CD cord-010119-t1x9gknd 6233 29 molecules/ molecules/ CD cord-010119-t1x9gknd 6233 30 cell cell NN cord-010119-t1x9gknd 6233 31 . . . cord-010119-t1x9gknd 6234 1 A a DT cord-010119-t1x9gknd 6234 2 number number NN cord-010119-t1x9gknd 6234 3 of of IN cord-010119-t1x9gknd 6234 4 flow flow NN cord-010119-t1x9gknd 6234 5 cytometric cytometric NN cord-010119-t1x9gknd 6234 6 methods method NNS cord-010119-t1x9gknd 6234 7 for for IN cord-010119-t1x9gknd 6234 8 the the DT cord-010119-t1x9gknd 6234 9 detection detection NN cord-010119-t1x9gknd 6234 10 of of IN cord-010119-t1x9gknd 6234 11 RBC RBC NNP cord-010119-t1x9gknd 6234 12 - - HYPH cord-010119-t1x9gknd 6234 13 bound bind VBN cord-010119-t1x9gknd 6234 14 C3d C3d NNP cord-010119-t1x9gknd 6234 15 have have VBP cord-010119-t1x9gknd 6234 16 been be VBN cord-010119-t1x9gknd 6234 17 published publish VBN cord-010119-t1x9gknd 6234 18 . . . cord-010119-t1x9gknd 6235 1 However however RB cord-010119-t1x9gknd 6235 2 , , , cord-010119-t1x9gknd 6235 3 these these DT cord-010119-t1x9gknd 6235 4 are be VBP cord-010119-t1x9gknd 6235 5 mainly mainly RB cord-010119-t1x9gknd 6235 6 designed design VBN cord-010119-t1x9gknd 6235 7 to to TO cord-010119-t1x9gknd 6235 8 quantify quantify VB cord-010119-t1x9gknd 6235 9 the the DT cord-010119-t1x9gknd 6235 10 fraction fraction NN cord-010119-t1x9gknd 6235 11 of of IN cord-010119-t1x9gknd 6235 12 RBCs rbc NNS cord-010119-t1x9gknd 6235 13 with with IN cord-010119-t1x9gknd 6235 14 C3d c3d NN cord-010119-t1x9gknd 6235 15 - - HYPH cord-010119-t1x9gknd 6235 16 sensitization sensitization NN cord-010119-t1x9gknd 6235 17 . . . cord-010119-t1x9gknd 6236 1 The the DT cord-010119-t1x9gknd 6236 2 aim aim NN cord-010119-t1x9gknd 6236 3 of of IN cord-010119-t1x9gknd 6236 4 this this DT cord-010119-t1x9gknd 6236 5 study study NN cord-010119-t1x9gknd 6236 6 is be VBZ cord-010119-t1x9gknd 6236 7 to to TO cord-010119-t1x9gknd 6236 8 present present VB cord-010119-t1x9gknd 6236 9 a a DT cord-010119-t1x9gknd 6236 10 flow flow NN cord-010119-t1x9gknd 6236 11 cytometric cytometric NN cord-010119-t1x9gknd 6236 12 method method NN cord-010119-t1x9gknd 6236 13 for for IN cord-010119-t1x9gknd 6236 14 the the DT cord-010119-t1x9gknd 6236 15 quantification quantification NN cord-010119-t1x9gknd 6236 16 of of IN cord-010119-t1x9gknd 6236 17 the the DT cord-010119-t1x9gknd 6236 18 level level NN cord-010119-t1x9gknd 6236 19 of of IN cord-010119-t1x9gknd 6236 20 RBCbound RBCbound NNP cord-010119-t1x9gknd 6236 21 C3d C3d NNP cord-010119-t1x9gknd 6236 22 . . . cord-010119-t1x9gknd 6237 1 Study Study NNP cord-010119-t1x9gknd 6237 2 Design Design NNP cord-010119-t1x9gknd 6237 3 / / SYM cord-010119-t1x9gknd 6237 4 Method method NN cord-010119-t1x9gknd 6237 5 : : : cord-010119-t1x9gknd 6237 6 Ten ten CD cord-010119-t1x9gknd 6237 7 microliters microliter NNS cord-010119-t1x9gknd 6237 8 ( ( -LRB- cord-010119-t1x9gknd 6237 9 uL uL NNP cord-010119-t1x9gknd 6237 10 ) ) -RRB- cord-010119-t1x9gknd 6237 11 of of IN cord-010119-t1x9gknd 6237 12 1:80 1:80 CD cord-010119-t1x9gknd 6237 13 ( ( -LRB- cord-010119-t1x9gknd 6237 14 after after IN cord-010119-t1x9gknd 6237 15 documenting document VBG cord-010119-t1x9gknd 6237 16 experimentally experimentally RB cord-010119-t1x9gknd 6237 17 that that IN cord-010119-t1x9gknd 6237 18 this this DT cord-010119-t1x9gknd 6237 19 amount amount NN cord-010119-t1x9gknd 6237 20 ensured ensure VBD cord-010119-t1x9gknd 6237 21 maximum maximum JJ cord-010119-t1x9gknd 6237 22 binding binding NN cord-010119-t1x9gknd 6237 23 of of IN cord-010119-t1x9gknd 6237 24 anti anti JJ cord-010119-t1x9gknd 6237 25 - - JJ cord-010119-t1x9gknd 6237 26 C3d c3d JJ cord-010119-t1x9gknd 6237 27 ) ) -RRB- cord-010119-t1x9gknd 6237 28 mouse mouse NN cord-010119-t1x9gknd 6237 29 monoclonal monoclonal JJ cord-010119-t1x9gknd 6237 30 anti anti JJ cord-010119-t1x9gknd 6237 31 - - JJ cord-010119-t1x9gknd 6237 32 human human JJ cord-010119-t1x9gknd 6237 33 anti anti JJ cord-010119-t1x9gknd 6237 34 - - JJ cord-010119-t1x9gknd 6237 35 C3d c3d JJ cord-010119-t1x9gknd 6237 36 ( ( -LRB- cord-010119-t1x9gknd 6237 37 Abcam Abcam NNP cord-010119-t1x9gknd 6237 38 , , , cord-010119-t1x9gknd 6237 39 clone clone NN cord-010119-t1x9gknd 6237 40 7c10 7c10 CD cord-010119-t1x9gknd 6237 41 ) ) -RRB- cord-010119-t1x9gknd 6237 42 were be VBD cord-010119-t1x9gknd 6237 43 added add VBN cord-010119-t1x9gknd 6237 44 to to IN cord-010119-t1x9gknd 6237 45 5 5 CD cord-010119-t1x9gknd 6237 46 uL ul NN cord-010119-t1x9gknd 6237 47 of of IN cord-010119-t1x9gknd 6237 48 a a DT cord-010119-t1x9gknd 6237 49 2.5 2.5 CD cord-010119-t1x9gknd 6237 50 % % NN cord-010119-t1x9gknd 6237 51 RBC RBC NNP cord-010119-t1x9gknd 6237 52 suspension suspension NN cord-010119-t1x9gknd 6237 53 . . . cord-010119-t1x9gknd 6238 1 After after IN cord-010119-t1x9gknd 6238 2 incubation incubation NN cord-010119-t1x9gknd 6238 3 for for IN cord-010119-t1x9gknd 6238 4 60 60 CD cord-010119-t1x9gknd 6238 5 minutes minute NNS cord-010119-t1x9gknd 6238 6 at at IN cord-010119-t1x9gknd 6238 7 4C 4c CD cord-010119-t1x9gknd 6238 8 , , , cord-010119-t1x9gknd 6238 9 samples sample NNS cord-010119-t1x9gknd 6238 10 were be VBD cord-010119-t1x9gknd 6238 11 washed wash VBN cord-010119-t1x9gknd 6238 12 x3 x3 NNP cord-010119-t1x9gknd 6238 13 , , , cord-010119-t1x9gknd 6238 14 and and CC cord-010119-t1x9gknd 6238 15 25 25 CD cord-010119-t1x9gknd 6238 16 uL ul CD cord-010119-t1x9gknd 6238 17 of of IN cord-010119-t1x9gknd 6238 18 1:10 1:10 CD cord-010119-t1x9gknd 6238 19 diluted diluted JJ cord-010119-t1x9gknd 6238 20 anti anti JJ cord-010119-t1x9gknd 6238 21 - - JJ cord-010119-t1x9gknd 6238 22 mouse mouse JJ cord-010119-t1x9gknd 6238 23 - - HYPH cord-010119-t1x9gknd 6238 24 F(ab)2-PE F(ab)2-PE NNP cord-010119-t1x9gknd 6238 25 ( ( -LRB- cord-010119-t1x9gknd 6238 26 RO480 RO480 NNP cord-010119-t1x9gknd 6238 27 , , , cord-010119-t1x9gknd 6238 28 DAKO DAKO NNP cord-010119-t1x9gknd 6238 29 ) ) -RRB- cord-010119-t1x9gknd 6238 30 were be VBD cord-010119-t1x9gknd 6238 31 added add VBN cord-010119-t1x9gknd 6238 32 . . . cord-010119-t1x9gknd 6239 1 After after IN cord-010119-t1x9gknd 6239 2 incubation incubation NN cord-010119-t1x9gknd 6239 3 at at IN cord-010119-t1x9gknd 6239 4 4C 4c CD cord-010119-t1x9gknd 6239 5 , , , cord-010119-t1x9gknd 6239 6 samples sample NNS cord-010119-t1x9gknd 6239 7 were be VBD cord-010119-t1x9gknd 6239 8 washed wash VBN cord-010119-t1x9gknd 6239 9 and and CC cord-010119-t1x9gknd 6239 10 resuspended resuspend VBN cord-010119-t1x9gknd 6239 11 before before IN cord-010119-t1x9gknd 6239 12 being be VBG cord-010119-t1x9gknd 6239 13 acquired acquire VBN cord-010119-t1x9gknd 6239 14 on on IN cord-010119-t1x9gknd 6239 15 a a DT cord-010119-t1x9gknd 6239 16 flow flow NN cord-010119-t1x9gknd 6239 17 cytometer cytometer NN cord-010119-t1x9gknd 6239 18 ( ( -LRB- cord-010119-t1x9gknd 6239 19 Becton Becton NNP cord-010119-t1x9gknd 6239 20 Dickinson Dickinson NNP cord-010119-t1x9gknd 6239 21 FACSCanto FACSCanto NNP cord-010119-t1x9gknd 6239 22 II II NNP cord-010119-t1x9gknd 6239 23 ) ) -RRB- cord-010119-t1x9gknd 6239 24 . . . cord-010119-t1x9gknd 6240 1 To to TO cord-010119-t1x9gknd 6240 2 enable enable VB cord-010119-t1x9gknd 6240 3 calibration calibration NN cord-010119-t1x9gknd 6240 4 of of IN cord-010119-t1x9gknd 6240 5 fluorescence fluorescence NN cord-010119-t1x9gknd 6240 6 signals signal NNS cord-010119-t1x9gknd 6240 7 in in IN cord-010119-t1x9gknd 6240 8 antibody antibody NN cord-010119-t1x9gknd 6240 9 binding bind VBG cord-010119-t1x9gknd 6240 10 capacity capacity NN cord-010119-t1x9gknd 6240 11 ( ( -LRB- cord-010119-t1x9gknd 6240 12 ABC ABC NNP cord-010119-t1x9gknd 6240 13 ) ) -RRB- cord-010119-t1x9gknd 6240 14 , , , cord-010119-t1x9gknd 6240 15 a a DT cord-010119-t1x9gknd 6240 16 calibration calibration NN cord-010119-t1x9gknd 6240 17 standard standard NN cord-010119-t1x9gknd 6240 18 ( ( -LRB- cord-010119-t1x9gknd 6240 19 DAKO DAKO NNP cord-010119-t1x9gknd 6240 20 QIFIKIT QIFIKIT NNP cord-010119-t1x9gknd 6240 21 ) ) -RRB- cord-010119-t1x9gknd 6240 22 stained stain VBN cord-010119-t1x9gknd 6240 23 with with IN cord-010119-t1x9gknd 6240 24 RO480 ro480 NN cord-010119-t1x9gknd 6240 25 was be VBD cord-010119-t1x9gknd 6240 26 run run VBN cord-010119-t1x9gknd 6240 27 in in IN cord-010119-t1x9gknd 6240 28 parallel parallel NN cord-010119-t1x9gknd 6240 29 with with IN cord-010119-t1x9gknd 6240 30 all all DT cord-010119-t1x9gknd 6240 31 experiments experiment NNS cord-010119-t1x9gknd 6240 32 . . . cord-010119-t1x9gknd 6241 1 Background background NN cord-010119-t1x9gknd 6241 2 fluorescence fluorescence NN cord-010119-t1x9gknd 6241 3 ( ( -LRB- cord-010119-t1x9gknd 6241 4 in in IN cord-010119-t1x9gknd 6241 5 ABC ABC NNP cord-010119-t1x9gknd 6241 6 ) ) -RRB- cord-010119-t1x9gknd 6241 7 was be VBD cord-010119-t1x9gknd 6241 8 subtracted subtract VBN cord-010119-t1x9gknd 6241 9 to to TO cord-010119-t1x9gknd 6241 10 yield yield VB cord-010119-t1x9gknd 6241 11 net net JJ cord-010119-t1x9gknd 6241 12 ABC ABC NNP cord-010119-t1x9gknd 6241 13 values value NNS cord-010119-t1x9gknd 6241 14 corresponding correspond VBG cord-010119-t1x9gknd 6241 15 to to IN cord-010119-t1x9gknd 6241 16 specific specific JJ cord-010119-t1x9gknd 6241 17 staining staining NN cord-010119-t1x9gknd 6241 18 with with IN cord-010119-t1x9gknd 6241 19 anti anti JJ cord-010119-t1x9gknd 6241 20 - - JJ cord-010119-t1x9gknd 6241 21 C3d c3d JJ cord-010119-t1x9gknd 6241 22 . . . cord-010119-t1x9gknd 6242 1 The the DT cord-010119-t1x9gknd 6242 2 assay assay NN cord-010119-t1x9gknd 6242 3 , , , cord-010119-t1x9gknd 6242 4 in in IN cord-010119-t1x9gknd 6242 5 parallel parallel NN cord-010119-t1x9gknd 6242 6 with with IN cord-010119-t1x9gknd 6242 7 our -PRON- PRP$ cord-010119-t1x9gknd 6242 8 routine routine JJ cord-010119-t1x9gknd 6242 9 DAT DAT NNP cord-010119-t1x9gknd 6242 10 ( ( -LRB- cord-010119-t1x9gknd 6242 11 DC DC NNP cord-010119-t1x9gknd 6242 12 - - HYPH cord-010119-t1x9gknd 6242 13 Screening Screening NNP cord-010119-t1x9gknd 6242 14 I I NNP cord-010119-t1x9gknd 6242 15 , , , cord-010119-t1x9gknd 6242 16 ID ID NNP cord-010119-t1x9gknd 6242 17 - - HYPH cord-010119-t1x9gknd 6242 18 Card Card NNP cord-010119-t1x9gknd 6242 19 , , , cord-010119-t1x9gknd 6242 20 gel gel NN cord-010119-t1x9gknd 6242 21 card card NN cord-010119-t1x9gknd 6242 22 , , , cord-010119-t1x9gknd 6242 23 BioRad BioRad NNP cord-010119-t1x9gknd 6242 24 ) ) -RRB- cord-010119-t1x9gknd 6242 25 was be VBD cord-010119-t1x9gknd 6242 26 applied apply VBN cord-010119-t1x9gknd 6242 27 to to IN cord-010119-t1x9gknd 6242 28 a a DT cord-010119-t1x9gknd 6242 29 series series NN cord-010119-t1x9gknd 6242 30 of of IN cord-010119-t1x9gknd 6242 31 A1 A1 NNP cord-010119-t1x9gknd 6242 32 RBCs rbc NNS cord-010119-t1x9gknd 6242 33 stained stain VBN cord-010119-t1x9gknd 6242 34 with with IN cord-010119-t1x9gknd 6242 35 10 10 CD cord-010119-t1x9gknd 6242 36 levels level NNS cord-010119-t1x9gknd 6242 37 ( ( -LRB- cord-010119-t1x9gknd 6242 38 2fold 2fold CD cord-010119-t1x9gknd 6242 39 dilution dilution NN cord-010119-t1x9gknd 6242 40 , , , cord-010119-t1x9gknd 6242 41 1:1 1:1 CD cord-010119-t1x9gknd 6242 42 -1:512 -1:512 NNS cord-010119-t1x9gknd 6242 43 ) ) -RRB- cord-010119-t1x9gknd 6242 44 of of IN cord-010119-t1x9gknd 6242 45 O o NN cord-010119-t1x9gknd 6242 46 serum serum NN cord-010119-t1x9gknd 6242 47 with with IN cord-010119-t1x9gknd 6242 48 high high JJ cord-010119-t1x9gknd 6242 49 titer titer NN cord-010119-t1x9gknd 6242 50 anti anti JJ cord-010119-t1x9gknd 6242 51 - - NN cord-010119-t1x9gknd 6242 52 A. a. JJ cord-010119-t1x9gknd 6243 1 To to TO cord-010119-t1x9gknd 6243 2 estimate estimate VB cord-010119-t1x9gknd 6243 3 the the DT cord-010119-t1x9gknd 6243 4 normal normal JJ cord-010119-t1x9gknd 6243 5 range range NN cord-010119-t1x9gknd 6243 6 of of IN cord-010119-t1x9gknd 6243 7 RBC RBC NNP cord-010119-t1x9gknd 6243 8 - - HYPH cord-010119-t1x9gknd 6243 9 bound bind VBN cord-010119-t1x9gknd 6243 10 C3d C3d NNP cord-010119-t1x9gknd 6243 11 , , , cord-010119-t1x9gknd 6243 12 EDTA EDTA NNP cord-010119-t1x9gknd 6243 13 - - HYPH cord-010119-t1x9gknd 6243 14 stabilized stabilize VBD cord-010119-t1x9gknd 6243 15 samples sample NNS cord-010119-t1x9gknd 6243 16 from from IN cord-010119-t1x9gknd 6243 17 4 4 CD cord-010119-t1x9gknd 6243 18 healthy healthy JJ cord-010119-t1x9gknd 6243 19 donors donor NNS cord-010119-t1x9gknd 6243 20 were be VBD cord-010119-t1x9gknd 6243 21 tested test VBN cord-010119-t1x9gknd 6243 22 . . . cord-010119-t1x9gknd 6244 1 Finally finally RB cord-010119-t1x9gknd 6244 2 , , , cord-010119-t1x9gknd 6244 3 the the DT cord-010119-t1x9gknd 6244 4 assay assay NN cord-010119-t1x9gknd 6244 5 was be VBD cord-010119-t1x9gknd 6244 6 applied apply VBN cord-010119-t1x9gknd 6244 7 to to IN cord-010119-t1x9gknd 6244 8 a a DT cord-010119-t1x9gknd 6244 9 sample sample NN cord-010119-t1x9gknd 6244 10 from from IN cord-010119-t1x9gknd 6244 11 a a DT cord-010119-t1x9gknd 6244 12 patient patient NN cord-010119-t1x9gknd 6244 13 with with IN cord-010119-t1x9gknd 6244 14 clinical clinical JJ cord-010119-t1x9gknd 6244 15 AIHA AIHA NNP cord-010119-t1x9gknd 6244 16 with with IN cord-010119-t1x9gknd 6244 17 an an DT cord-010119-t1x9gknd 6244 18 inconclusive inconclusive JJ cord-010119-t1x9gknd 6244 19 DAT dat NN cord-010119-t1x9gknd 6244 20 due due JJ cord-010119-t1x9gknd 6244 21 to to IN cord-010119-t1x9gknd 6244 22 unspecific unspecific JJ cord-010119-t1x9gknd 6244 23 DAT DAT NNP cord-010119-t1x9gknd 6244 24 polyreactivity polyreactivity NN cord-010119-t1x9gknd 6244 25 . . . cord-010119-t1x9gknd 6245 1 Results/ Results/ . cord-010119-t1x9gknd 6246 1 Finding finding NN cord-010119-t1x9gknd 6246 2 : : : cord-010119-t1x9gknd 6247 1 The the DT cord-010119-t1x9gknd 6247 2 correlation correlation NN cord-010119-t1x9gknd 6247 3 of of IN cord-010119-t1x9gknd 6247 4 the the DT cord-010119-t1x9gknd 6247 5 net net JJ cord-010119-t1x9gknd 6247 6 level level NN cord-010119-t1x9gknd 6247 7 of of IN cord-010119-t1x9gknd 6247 8 RBC RBC NNP cord-010119-t1x9gknd 6247 9 - - HYPH cord-010119-t1x9gknd 6247 10 bound bind VBN cord-010119-t1x9gknd 6247 11 C3d c3d NN cord-010119-t1x9gknd 6248 1 ( ( -LRB- cord-010119-t1x9gknd 6248 2 values value NNS cord-010119-t1x9gknd 6248 3 ranging range VBG cord-010119-t1x9gknd 6248 4 from from IN cord-010119-t1x9gknd 6248 5 0 0 CD cord-010119-t1x9gknd 6248 6 to to IN cord-010119-t1x9gknd 6248 7 3,393 3,393 CD cord-010119-t1x9gknd 6248 8 ABC ABC NNP cord-010119-t1x9gknd 6248 9 ) ) -RRB- cord-010119-t1x9gknd 6248 10 with with IN cord-010119-t1x9gknd 6248 11 level level NN cord-010119-t1x9gknd 6248 12 of of IN cord-010119-t1x9gknd 6248 13 0-serum 0-serum CD cord-010119-t1x9gknd 6248 14 dilution dilution NN cord-010119-t1x9gknd 6248 15 ( ( -LRB- cord-010119-t1x9gknd 6248 16 used use VBN cord-010119-t1x9gknd 6248 17 to to TO cord-010119-t1x9gknd 6248 18 sensitize sensitize VB cord-010119-t1x9gknd 6248 19 A1 A1 NNP cord-010119-t1x9gknd 6248 20 RBCs rbc NNS cord-010119-t1x9gknd 6248 21 ) ) -RRB- cord-010119-t1x9gknd 6248 22 proved prove VBD cord-010119-t1x9gknd 6248 23 to to TO cord-010119-t1x9gknd 6248 24 be be VB cord-010119-t1x9gknd 6248 25 highly highly RB cord-010119-t1x9gknd 6248 26 linear linear JJ cord-010119-t1x9gknd 6248 27 ( ( -LRB- cord-010119-t1x9gknd 6248 28 logarithmic logarithmic JJ cord-010119-t1x9gknd 6248 29 vs. vs. FW cord-010119-t1x9gknd 6248 30 logarithmic logarithmic JJ cord-010119-t1x9gknd 6248 31 plot plot NN cord-010119-t1x9gknd 6248 32 ; ; : cord-010119-t1x9gknd 6248 33 r2 r2 NNP cord-010119-t1x9gknd 6248 34 5 5 CD cord-010119-t1x9gknd 6248 35 0.97 0.97 CD cord-010119-t1x9gknd 6248 36 , , , cord-010119-t1x9gknd 6248 37 p p NN cord-010119-t1x9gknd 6248 38 < < XX cord-010119-t1x9gknd 6248 39 0.0001 0.0001 CD cord-010119-t1x9gknd 6248 40 ) ) -RRB- cord-010119-t1x9gknd 6248 41 . . . cord-010119-t1x9gknd 6249 1 Compared compare VBN cord-010119-t1x9gknd 6249 2 with with IN cord-010119-t1x9gknd 6249 3 DC DC NNP cord-010119-t1x9gknd 6249 4 - - HYPH cord-010119-t1x9gknd 6249 5 Screening Screening NNP cord-010119-t1x9gknd 6249 6 1 1 CD cord-010119-t1x9gknd 6249 7 , , , cord-010119-t1x9gknd 6249 8 the the DT cord-010119-t1x9gknd 6249 9 sensitivity sensitivity NN cord-010119-t1x9gknd 6249 10 of of IN cord-010119-t1x9gknd 6249 11 the the DT cord-010119-t1x9gknd 6249 12 flow flow NN cord-010119-t1x9gknd 6249 13 cytometric cytometric NN cord-010119-t1x9gknd 6249 14 assay assay NN cord-010119-t1x9gknd 6249 15 was be VBD cord-010119-t1x9gknd 6249 16 superior superior JJ cord-010119-t1x9gknd 6249 17 . . . cord-010119-t1x9gknd 6250 1 It -PRON- PRP cord-010119-t1x9gknd 6250 2 detected detect VBD cord-010119-t1x9gknd 6250 3 C3d c3d CD cord-010119-t1x9gknd 6250 4 sensitization sensitization NN cord-010119-t1x9gknd 6250 5 at at IN cord-010119-t1x9gknd 6250 6 least least JJS cord-010119-t1x9gknd 6250 7 4 4 CD cord-010119-t1x9gknd 6250 8 dilution dilution NN cord-010119-t1x9gknd 6250 9 steps step NNS cord-010119-t1x9gknd 6250 10 further further RB cord-010119-t1x9gknd 6250 11 . . . cord-010119-t1x9gknd 6251 1 The the DT cord-010119-t1x9gknd 6251 2 median median JJ cord-010119-t1x9gknd 6251 3 normal normal JJ cord-010119-t1x9gknd 6251 4 level level NN cord-010119-t1x9gknd 6251 5 of of IN cord-010119-t1x9gknd 6251 6 RBC RBC NNP cord-010119-t1x9gknd 6251 7 - - HYPH cord-010119-t1x9gknd 6251 8 bound bind VBN cord-010119-t1x9gknd 6251 9 C3d C3d NNP cord-010119-t1x9gknd 6251 10 was be VBD cord-010119-t1x9gknd 6251 11 11 11 CD cord-010119-t1x9gknd 6251 12 ABC ABC NNP cord-010119-t1x9gknd 6251 13 ( ( -LRB- cord-010119-t1x9gknd 6251 14 range range NNP cord-010119-t1x9gknd 6251 15 7 7 CD cord-010119-t1x9gknd 6251 16 - - SYM cord-010119-t1x9gknd 6251 17 20 20 CD cord-010119-t1x9gknd 6251 18 ABC ABC NNP cord-010119-t1x9gknd 6251 19 , , , cord-010119-t1x9gknd 6251 20 n54 n54 NN cord-010119-t1x9gknd 6251 21 ) ) -RRB- cord-010119-t1x9gknd 6251 22 . . . cord-010119-t1x9gknd 6252 1 The the DT cord-010119-t1x9gknd 6252 2 assay assay NN cord-010119-t1x9gknd 6252 3 enabled enable VBD cord-010119-t1x9gknd 6252 4 demonstration demonstration NN cord-010119-t1x9gknd 6252 5 of of IN cord-010119-t1x9gknd 6252 6 specific specific JJ cord-010119-t1x9gknd 6252 7 C3d c3d NN cord-010119-t1x9gknd 6252 8 - - HYPH cord-010119-t1x9gknd 6252 9 sensitization sensitization NN cord-010119-t1x9gknd 6252 10 in in IN cord-010119-t1x9gknd 6252 11 the the DT cord-010119-t1x9gknd 6252 12 patient patient NN cord-010119-t1x9gknd 6252 13 ; ; : cord-010119-t1x9gknd 6252 14 the the DT cord-010119-t1x9gknd 6252 15 level level NN cord-010119-t1x9gknd 6252 16 of of IN cord-010119-t1x9gknd 6252 17 RBC RBC NNP cord-010119-t1x9gknd 6252 18 - - HYPH cord-010119-t1x9gknd 6252 19 bound bind VBN cord-010119-t1x9gknd 6252 20 C3d C3d NNP cord-010119-t1x9gknd 6252 21 in in IN cord-010119-t1x9gknd 6252 22 the the DT cord-010119-t1x9gknd 6252 23 sample sample NN cord-010119-t1x9gknd 6252 24 was be VBD cord-010119-t1x9gknd 6252 25 significantly significantly RB cord-010119-t1x9gknd 6252 26 elevated elevate VBN cord-010119-t1x9gknd 6252 27 ( ( -LRB- cord-010119-t1x9gknd 6252 28 1,907 1,907 CD cord-010119-t1x9gknd 6252 29 ABC ABC NNP cord-010119-t1x9gknd 6252 30 ) ) -RRB- cord-010119-t1x9gknd 6252 31 . . . cord-010119-t1x9gknd 6253 1 Conclusion conclusion NN cord-010119-t1x9gknd 6253 2 : : : cord-010119-t1x9gknd 6254 1 The the DT cord-010119-t1x9gknd 6254 2 presented present VBN cord-010119-t1x9gknd 6254 3 flow flow NN cord-010119-t1x9gknd 6254 4 cytometric cytometric NN cord-010119-t1x9gknd 6254 5 assay assay NN cord-010119-t1x9gknd 6254 6 is be VBZ cord-010119-t1x9gknd 6254 7 capable capable JJ cord-010119-t1x9gknd 6254 8 of of IN cord-010119-t1x9gknd 6254 9 quantifying quantify VBG cord-010119-t1x9gknd 6254 10 the the DT cord-010119-t1x9gknd 6254 11 level level NN cord-010119-t1x9gknd 6254 12 of of IN cord-010119-t1x9gknd 6254 13 RBC RBC NNP cord-010119-t1x9gknd 6254 14 - - HYPH cord-010119-t1x9gknd 6254 15 bound bind VBN cord-010119-t1x9gknd 6254 16 with with IN cord-010119-t1x9gknd 6254 17 a a DT cord-010119-t1x9gknd 6254 18 high high JJ cord-010119-t1x9gknd 6254 19 degree degree NN cord-010119-t1x9gknd 6254 20 of of IN cord-010119-t1x9gknd 6254 21 linearity linearity NN cord-010119-t1x9gknd 6254 22 and and CC cord-010119-t1x9gknd 6254 23 analytical analytical JJ cord-010119-t1x9gknd 6254 24 sensitivity sensitivity NN cord-010119-t1x9gknd 6254 25 . . . cord-010119-t1x9gknd 6255 1 Further further RB cord-010119-t1x9gknd 6255 2 , , , cord-010119-t1x9gknd 6255 3 it -PRON- PRP cord-010119-t1x9gknd 6255 4 is be VBZ cord-010119-t1x9gknd 6255 5 capable capable JJ cord-010119-t1x9gknd 6255 6 of of IN cord-010119-t1x9gknd 6255 7 quantifying quantify VBG cord-010119-t1x9gknd 6255 8 the the DT cord-010119-t1x9gknd 6255 9 level level NN cord-010119-t1x9gknd 6255 10 of of IN cord-010119-t1x9gknd 6255 11 RBC RBC NNP cord-010119-t1x9gknd 6255 12 - - HYPH cord-010119-t1x9gknd 6255 13 bound bind VBN cord-010119-t1x9gknd 6255 14 C3d C3d NNP cord-010119-t1x9gknd 6255 15 in in IN cord-010119-t1x9gknd 6255 16 DAT DAT NNP cord-010119-t1x9gknd 6255 17 polyreactive polyreactive NNP cord-010119-t1x9gknd 6255 18 samples sample NNS cord-010119-t1x9gknd 6255 19 . . . cord-010119-t1x9gknd 6256 1 Background Background NNP cord-010119-t1x9gknd 6256 2 / / SYM cord-010119-t1x9gknd 6256 3 Case Case NNP cord-010119-t1x9gknd 6256 4 Studies Studies NNPS cord-010119-t1x9gknd 6256 5 : : : cord-010119-t1x9gknd 6256 6 ABO ABO NNP cord-010119-t1x9gknd 6256 7 blood blood NN cord-010119-t1x9gknd 6256 8 group group NN cord-010119-t1x9gknd 6256 9 system system NN cord-010119-t1x9gknd 6256 10 of of IN cord-010119-t1x9gknd 6256 11 red red JJ cord-010119-t1x9gknd 6256 12 blood blood NN cord-010119-t1x9gknd 6256 13 cells cell NNS cord-010119-t1x9gknd 6256 14 ( ( -LRB- cord-010119-t1x9gknd 6256 15 RBCs rbc NNS cord-010119-t1x9gknd 6256 16 ) ) -RRB- cord-010119-t1x9gknd 6256 17 consists consist VBZ cord-010119-t1x9gknd 6256 18 of of IN cord-010119-t1x9gknd 6256 19 A a NN cord-010119-t1x9gknd 6256 20 and and CC cord-010119-t1x9gknd 6256 21 B b NN cord-010119-t1x9gknd 6256 22 oligosaccharide oligosaccharide NN cord-010119-t1x9gknd 6256 23 antigens antigen NNS cord-010119-t1x9gknd 6256 24 and and CC cord-010119-t1x9gknd 6256 25 anti anti JJ cord-010119-t1x9gknd 6256 26 - - JJ cord-010119-t1x9gknd 6256 27 A a JJ cord-010119-t1x9gknd 6256 28 and and CC cord-010119-t1x9gknd 6256 29 anti anti JJ cord-010119-t1x9gknd 6256 30 - - JJ cord-010119-t1x9gknd 6256 31 B b JJ cord-010119-t1x9gknd 6256 32 antibodies antibody NNS cord-010119-t1x9gknd 6256 33 against against IN cord-010119-t1x9gknd 6256 34 these these DT cord-010119-t1x9gknd 6256 35 antigens antigen NNS cord-010119-t1x9gknd 6256 36 , , , cord-010119-t1x9gknd 6256 37 which which WDT cord-010119-t1x9gknd 6256 38 are be VBP cord-010119-t1x9gknd 6256 39 present present JJ cord-010119-t1x9gknd 6256 40 in in IN cord-010119-t1x9gknd 6256 41 the the DT cord-010119-t1x9gknd 6256 42 sera sera NNP cord-010119-t1x9gknd 6256 43 of of IN cord-010119-t1x9gknd 6256 44 individuals individual NNS cord-010119-t1x9gknd 6256 45 who who WP cord-010119-t1x9gknd 6256 46 do do VBP cord-010119-t1x9gknd 6256 47 not not RB cord-010119-t1x9gknd 6256 48 express express VB cord-010119-t1x9gknd 6256 49 the the DT cord-010119-t1x9gknd 6256 50 antigen(s)(Landsteiner antigen(s)(Landsteiner NNP cord-010119-t1x9gknd 6256 51 's 's POS cord-010119-t1x9gknd 6256 52 Law Law NNP cord-010119-t1x9gknd 6256 53 ) ) -RRB- cord-010119-t1x9gknd 6256 54 . . . cord-010119-t1x9gknd 6257 1 Because because IN cord-010119-t1x9gknd 6257 2 of of IN cord-010119-t1x9gknd 6257 3 the the DT cord-010119-t1x9gknd 6257 4 expression expression NN cord-010119-t1x9gknd 6257 5 of of IN cord-010119-t1x9gknd 6257 6 those those DT cord-010119-t1x9gknd 6257 7 antigens antigen NNS cord-010119-t1x9gknd 6257 8 on on IN cord-010119-t1x9gknd 6257 9 some some DT cord-010119-t1x9gknd 6257 10 epithelial epithelial JJ cord-010119-t1x9gknd 6257 11 and and CC cord-010119-t1x9gknd 6257 12 endothelial endothelial JJ cord-010119-t1x9gknd 6257 13 cells cell NNS cord-010119-t1x9gknd 6257 14 in in IN cord-010119-t1x9gknd 6257 15 the the DT cord-010119-t1x9gknd 6257 16 body body NN cord-010119-t1x9gknd 6257 17 , , , cord-010119-t1x9gknd 6257 18 the the DT cord-010119-t1x9gknd 6257 19 ABO ABO NNP cord-010119-t1x9gknd 6257 20 matching matching NN cord-010119-t1x9gknd 6257 21 is be VBZ cord-010119-t1x9gknd 6257 22 critical critical JJ cord-010119-t1x9gknd 6257 23 not not RB cord-010119-t1x9gknd 6257 24 only only RB cord-010119-t1x9gknd 6257 25 in in IN cord-010119-t1x9gknd 6257 26 blood blood NN cord-010119-t1x9gknd 6257 27 transfusion transfusion NN cord-010119-t1x9gknd 6257 28 , , , cord-010119-t1x9gknd 6257 29 but but CC cord-010119-t1x9gknd 6257 30 also also RB cord-010119-t1x9gknd 6257 31 in in IN cord-010119-t1x9gknd 6257 32 cell cell NN cord-010119-t1x9gknd 6257 33 / / SYM cord-010119-t1x9gknd 6257 34 tissue tissue NN cord-010119-t1x9gknd 6257 35 / / SYM cord-010119-t1x9gknd 6257 36 organ organ NN cord-010119-t1x9gknd 6257 37 transplantation transplantation NN cord-010119-t1x9gknd 6257 38 . . . cord-010119-t1x9gknd 6258 1 In in IN cord-010119-t1x9gknd 6258 2 spite spite NN cord-010119-t1x9gknd 6258 3 of of IN cord-010119-t1x9gknd 6258 4 the the DT cord-010119-t1x9gknd 6258 5 fact fact NN cord-010119-t1x9gknd 6258 6 that that IN cord-010119-t1x9gknd 6258 7 both both DT cord-010119-t1x9gknd 6258 8 antigens antigen NNS cord-010119-t1x9gknd 6258 9 and and CC cord-010119-t1x9gknd 6258 10 antibodies antibody NNS cord-010119-t1x9gknd 6258 11 are be VBP cord-010119-t1x9gknd 6258 12 involved involve VBN cord-010119-t1x9gknd 6258 13 , , , cord-010119-t1x9gknd 6258 14 these these DT cord-010119-t1x9gknd 6258 15 genetic genetic JJ cord-010119-t1x9gknd 6258 16 traits trait NNS cord-010119-t1x9gknd 6258 17 are be VBP cord-010119-t1x9gknd 6258 18 specified specify VBN cord-010119-t1x9gknd 6258 19 by by IN cord-010119-t1x9gknd 6258 20 a a DT cord-010119-t1x9gknd 6258 21 single single JJ cord-010119-t1x9gknd 6258 22 genetic genetic JJ cord-010119-t1x9gknd 6258 23 locus locus NN cord-010119-t1x9gknd 6258 24 of of IN cord-010119-t1x9gknd 6258 25 ABO ABO NNP cord-010119-t1x9gknd 6258 26 . . . cord-010119-t1x9gknd 6259 1 Forssman Forssman NNP cord-010119-t1x9gknd 6259 2 ( ( -LRB- cord-010119-t1x9gknd 6259 3 FORS FORS NNP cord-010119-t1x9gknd 6259 4 ) ) -RRB- cord-010119-t1x9gknd 6259 5 system system NN cord-010119-t1x9gknd 6259 6 is be VBZ cord-010119-t1x9gknd 6259 7 another another DT cord-010119-t1x9gknd 6259 8 RBC RBC NNP cord-010119-t1x9gknd 6259 9 blood blood NN cord-010119-t1x9gknd 6259 10 group group NN cord-010119-t1x9gknd 6259 11 system system NN cord-010119-t1x9gknd 6259 12 which which WDT cord-010119-t1x9gknd 6259 13 consists consist VBZ cord-010119-t1x9gknd 6259 14 in in IN cord-010119-t1x9gknd 6259 15 a a DT cord-010119-t1x9gknd 6259 16 glycosylation glycosylation NN cord-010119-t1x9gknd 6259 17 polymorphism polymorphism NN cord-010119-t1x9gknd 6259 18 specified specify VBN cord-010119-t1x9gknd 6259 19 by by IN cord-010119-t1x9gknd 6259 20 the the DT cord-010119-t1x9gknd 6259 21 GBGT1 GBGT1 NNP cord-010119-t1x9gknd 6259 22 gene gene NN cord-010119-t1x9gknd 6259 23 . . . cord-010119-t1x9gknd 6260 1 In in IN cord-010119-t1x9gknd 6260 2 humans human NNS cord-010119-t1x9gknd 6260 3 , , , cord-010119-t1x9gknd 6260 4 the the DT cord-010119-t1x9gknd 6260 5 ABO ABO NNP cord-010119-t1x9gknd 6260 6 and and CC cord-010119-t1x9gknd 6260 7 GBGT1 gbgt1 VB cord-010119-t1x9gknd 6260 8 genetic genetic JJ cord-010119-t1x9gknd 6260 9 loci locus NNS cord-010119-t1x9gknd 6260 10 are be VBP cord-010119-t1x9gknd 6260 11 located locate VBN cord-010119-t1x9gknd 6260 12 on on IN cord-010119-t1x9gknd 6260 13 chromosome chromosome NN cord-010119-t1x9gknd 6260 14 9q34 9q34 CD cord-010119-t1x9gknd 6260 15 , , , cord-010119-t1x9gknd 6260 16 and and CC cord-010119-t1x9gknd 6260 17 the the DT cord-010119-t1x9gknd 6260 18 functional functional JJ cord-010119-t1x9gknd 6260 19 alleles allele NNS cord-010119-t1x9gknd 6260 20 encode encode VBP cord-010119-t1x9gknd 6260 21 A a NN cord-010119-t1x9gknd 6260 22 and and CC cord-010119-t1x9gknd 6260 23 B b NN cord-010119-t1x9gknd 6260 24 glycosyltransferases glycosyltransferase NNS cord-010119-t1x9gknd 6260 25 ( ( -LRB- cord-010119-t1x9gknd 6260 26 AT at IN cord-010119-t1x9gknd 6260 27 and and CC cord-010119-t1x9gknd 6260 28 BT BT NNP cord-010119-t1x9gknd 6260 29 ) ) -RRB- cord-010119-t1x9gknd 6260 30 and and CC cord-010119-t1x9gknd 6260 31 Forssman Forssman NNP cord-010119-t1x9gknd 6260 32 glycolipid glycolipid NNP cord-010119-t1x9gknd 6260 33 synthase synthase NN cord-010119-t1x9gknd 6260 34 ( ( -LRB- cord-010119-t1x9gknd 6260 35 FS FS NNP cord-010119-t1x9gknd 6260 36 ) ) -RRB- cord-010119-t1x9gknd 6260 37 , , , cord-010119-t1x9gknd 6260 38 which which WDT cord-010119-t1x9gknd 6260 39 catalyze catalyze VBP cord-010119-t1x9gknd 6260 40 the the DT cord-010119-t1x9gknd 6260 41 last last JJ cord-010119-t1x9gknd 6260 42 biosynthetic biosynthetic JJ cord-010119-t1x9gknd 6260 43 steps step NNS cord-010119-t1x9gknd 6260 44 of of IN cord-010119-t1x9gknd 6260 45 A a NN cord-010119-t1x9gknd 6260 46 and and CC cord-010119-t1x9gknd 6260 47 B b NN cord-010119-t1x9gknd 6260 48 , , , cord-010119-t1x9gknd 6260 49 and and CC cord-010119-t1x9gknd 6260 50 Forssman Forssman NNP cord-010119-t1x9gknd 6260 51 ( ( -LRB- cord-010119-t1x9gknd 6260 52 FORS1 FORS1 NNP cord-010119-t1x9gknd 6260 53 ) ) -RRB- cord-010119-t1x9gknd 6260 54 oligosaccharide oligosaccharide NN cord-010119-t1x9gknd 6260 55 antigens antigen NNS cord-010119-t1x9gknd 6260 56 . . . cord-010119-t1x9gknd 6261 1 The the DT cord-010119-t1x9gknd 6261 2 molecular molecular JJ cord-010119-t1x9gknd 6261 3 genetic genetic JJ cord-010119-t1x9gknd 6261 4 bases basis NNS cord-010119-t1x9gknd 6261 5 for for IN cord-010119-t1x9gknd 6261 6 allelism allelism NN cord-010119-t1x9gknd 6261 7 of of IN cord-010119-t1x9gknd 6261 8 those those DT cord-010119-t1x9gknd 6261 9 two two CD cord-010119-t1x9gknd 6261 10 systems system NNS cord-010119-t1x9gknd 6261 11 in in IN cord-010119-t1x9gknd 6261 12 humans human NNS cord-010119-t1x9gknd 6261 13 have have VBP cord-010119-t1x9gknd 6261 14 been be VBN cord-010119-t1x9gknd 6261 15 well well RB cord-010119-t1x9gknd 6261 16 - - HYPH cord-010119-t1x9gknd 6261 17 elucidated elucidate VBN cord-010119-t1x9gknd 6261 18 . . . cord-010119-t1x9gknd 6262 1 The the DT cord-010119-t1x9gknd 6262 2 ABO ABO NNP cord-010119-t1x9gknd 6262 3 and and CC cord-010119-t1x9gknd 6262 4 GBGT1 GBGT1 NNP cord-010119-t1x9gknd 6262 5 genes gene NNS cord-010119-t1x9gknd 6262 6 are be VBP cord-010119-t1x9gknd 6262 7 also also RB cord-010119-t1x9gknd 6262 8 present present JJ cord-010119-t1x9gknd 6262 9 in in IN cord-010119-t1x9gknd 6262 10 some some DT cord-010119-t1x9gknd 6262 11 other other JJ cord-010119-t1x9gknd 6262 12 species specie NNS cord-010119-t1x9gknd 6262 13 in in IN cord-010119-t1x9gknd 6262 14 addition addition NN cord-010119-t1x9gknd 6262 15 to to IN cord-010119-t1x9gknd 6262 16 humans human NNS cord-010119-t1x9gknd 6262 17 . . . cord-010119-t1x9gknd 6263 1 However however RB cord-010119-t1x9gknd 6263 2 , , , cord-010119-t1x9gknd 6263 3 the the DT cord-010119-t1x9gknd 6263 4 presence presence NN cord-010119-t1x9gknd 6263 5 / / SYM cord-010119-t1x9gknd 6263 6 absence absence NN cord-010119-t1x9gknd 6263 7 and and CC cord-010119-t1x9gknd 6263 8 functionality functionality NN cord-010119-t1x9gknd 6263 9 / / SYM cord-010119-t1x9gknd 6263 10 non non NN cord-010119-t1x9gknd 6263 11 - - NN cord-010119-t1x9gknd 6263 12 functionality functionality NN cord-010119-t1x9gknd 6263 13 are be VBP cord-010119-t1x9gknd 6263 14 species species NN cord-010119-t1x9gknd 6263 15 - - HYPH cord-010119-t1x9gknd 6263 16 dependent dependent JJ cord-010119-t1x9gknd 6263 17 . . . cord-010119-t1x9gknd 6264 1 Molecular molecular JJ cord-010119-t1x9gknd 6264 2 mechanisms mechanism NNS cord-010119-t1x9gknd 6264 3 / / SYM cord-010119-t1x9gknd 6264 4 forces force NNS cord-010119-t1x9gknd 6264 5 that that WDT cord-010119-t1x9gknd 6264 6 created create VBD cord-010119-t1x9gknd 6264 7 this this DT cord-010119-t1x9gknd 6264 8 species species NN cord-010119-t1x9gknd 6264 9 divergence divergence NN cord-010119-t1x9gknd 6264 10 , , , cord-010119-t1x9gknd 6264 11 including include VBG cord-010119-t1x9gknd 6264 12 human human JJ cord-010119-t1x9gknd 6264 13 polymorphism polymorphism NN cord-010119-t1x9gknd 6264 14 , , , cord-010119-t1x9gknd 6264 15 were be VBD cord-010119-t1x9gknd 6264 16 unknown unknown JJ cord-010119-t1x9gknd 6264 17 . . . cord-010119-t1x9gknd 6265 1 Study Study NNP cord-010119-t1x9gknd 6265 2 Design Design NNP cord-010119-t1x9gknd 6265 3 / / SYM cord-010119-t1x9gknd 6265 4 Methods method NNS cord-010119-t1x9gknd 6265 5 : : : cord-010119-t1x9gknd 6265 6 Utilizing utilize VBG cord-010119-t1x9gknd 6265 7 genomic genomic JJ cord-010119-t1x9gknd 6265 8 information information NN cord-010119-t1x9gknd 6265 9 available available JJ cord-010119-t1x9gknd 6265 10 from from IN cord-010119-t1x9gknd 6265 11 Gen Gen NNP cord-010119-t1x9gknd 6265 12 - - HYPH cord-010119-t1x9gknd 6265 13 Bank Bank NNP cord-010119-t1x9gknd 6265 14 and and CC cord-010119-t1x9gknd 6265 15 Ensembl Ensembl NNP cord-010119-t1x9gknd 6265 16 databases database NNS cord-010119-t1x9gknd 6265 17 , , , cord-010119-t1x9gknd 6265 18 the the DT cord-010119-t1x9gknd 6265 19 gene gene NN cord-010119-t1x9gknd 6265 20 maps map NNS cord-010119-t1x9gknd 6265 21 of of IN cord-010119-t1x9gknd 6265 22 the the DT cord-010119-t1x9gknd 6265 23 chromosomal chromosomal JJ cord-010119-t1x9gknd 6265 24 region region NN cord-010119-t1x9gknd 6265 25 surrounding surround VBG cord-010119-t1x9gknd 6265 26 the the DT cord-010119-t1x9gknd 6265 27 ABO ABO NNP cord-010119-t1x9gknd 6265 28 and and CC cord-010119-t1x9gknd 6265 29 GBGT1 GBGT1 NNP cord-010119-t1x9gknd 6265 30 genes gene NNS cord-010119-t1x9gknd 6265 31 have have VBP cord-010119-t1x9gknd 6265 32 been be VBN cord-010119-t1x9gknd 6265 33 constructed construct VBN cord-010119-t1x9gknd 6265 34 of of IN cord-010119-t1x9gknd 6265 35 88 88 CD cord-010119-t1x9gknd 6265 36 vertebrate vertebrate NN cord-010119-t1x9gknd 6265 37 species specie NNS cord-010119-t1x9gknd 6265 38 . . . cord-010119-t1x9gknd 6266 1 Results/ Results/ . cord-010119-t1x9gknd 6267 1 Findings finding NNS cord-010119-t1x9gknd 6267 2 : : : cord-010119-t1x9gknd 6268 1 Extensive extensive JJ cord-010119-t1x9gknd 6268 2 similarities similarity NNS cord-010119-t1x9gknd 6268 3 were be VBD cord-010119-t1x9gknd 6268 4 observed observe VBN cord-010119-t1x9gknd 6268 5 in in IN cord-010119-t1x9gknd 6268 6 the the DT cord-010119-t1x9gknd 6268 7 kinds kind NNS cord-010119-t1x9gknd 6268 8 , , , cord-010119-t1x9gknd 6268 9 numbers number NNS cord-010119-t1x9gknd 6268 10 , , , cord-010119-t1x9gknd 6268 11 and and CC cord-010119-t1x9gknd 6268 12 orders order NNS cord-010119-t1x9gknd 6268 13 of of IN cord-010119-t1x9gknd 6268 14 genes gene NNS cord-010119-t1x9gknd 6268 15 , , , cord-010119-t1x9gknd 6268 16 as as RB cord-010119-t1x9gknd 6268 17 well well RB cord-010119-t1x9gknd 6268 18 as as IN cord-010119-t1x9gknd 6268 19 their -PRON- PRP$ cord-010119-t1x9gknd 6268 20 chromosomal chromosomal JJ cord-010119-t1x9gknd 6268 21 locations location NNS cord-010119-t1x9gknd 6268 22 . . . cord-010119-t1x9gknd 6269 1 However however RB cord-010119-t1x9gknd 6269 2 , , , cord-010119-t1x9gknd 6269 3 numerous numerous JJ cord-010119-t1x9gknd 6269 4 differences difference NNS cord-010119-t1x9gknd 6269 5 were be VBD cord-010119-t1x9gknd 6269 6 also also RB cord-010119-t1x9gknd 6269 7 identified identify VBN cord-010119-t1x9gknd 6269 8 . . . cord-010119-t1x9gknd 6270 1 These these DT cord-010119-t1x9gknd 6270 2 include include VBP cord-010119-t1x9gknd 6270 3 chromosomal chromosomal JJ cord-010119-t1x9gknd 6270 4 rearrangements rearrangement NNS cord-010119-t1x9gknd 6270 5 , , , cord-010119-t1x9gknd 6270 6 as as RB cord-010119-t1x9gknd 6270 7 well well RB cord-010119-t1x9gknd 6270 8 as as IN cord-010119-t1x9gknd 6270 9 the the DT cord-010119-t1x9gknd 6270 10 insertions insertion NNS cord-010119-t1x9gknd 6270 11 and and CC cord-010119-t1x9gknd 6270 12 amplifications amplification NNS cord-010119-t1x9gknd 6270 13 of of IN cord-010119-t1x9gknd 6270 14 specific specific JJ cord-010119-t1x9gknd 6270 15 genes gene NNS cord-010119-t1x9gknd 6270 16 . . . cord-010119-t1x9gknd 6271 1 Interestingly interestingly RB cord-010119-t1x9gknd 6271 2 , , , cord-010119-t1x9gknd 6271 3 the the DT cord-010119-t1x9gknd 6271 4 ABO ABO NNP cord-010119-t1x9gknd 6271 5 and and CC cord-010119-t1x9gknd 6271 6 GBGT1 GBGT1 NNP cord-010119-t1x9gknd 6271 7 genes gene NNS cord-010119-t1x9gknd 6271 8 were be VBD cord-010119-t1x9gknd 6271 9 found find VBN cord-010119-t1x9gknd 6271 10 located locate VBN cord-010119-t1x9gknd 6271 11 at at IN cord-010119-t1x9gknd 6271 12 the the DT cord-010119-t1x9gknd 6271 13 boundaries boundary NNS cord-010119-t1x9gknd 6271 14 of of IN cord-010119-t1x9gknd 6271 15 chromosomal chromosomal JJ cord-010119-t1x9gknd 6271 16 fragments fragment NNS cord-010119-t1x9gknd 6271 17 that that WDT cord-010119-t1x9gknd 6271 18 seem seem VBP cord-010119-t1x9gknd 6271 19 to to TO cord-010119-t1x9gknd 6271 20 have have VB cord-010119-t1x9gknd 6271 21 undergone undergo VBN cord-010119-t1x9gknd 6271 22 frequent frequent JJ cord-010119-t1x9gknd 6271 23 inversions inversion NNS cord-010119-t1x9gknd 6271 24 / / SYM cord-010119-t1x9gknd 6271 25 translocations translocation NNS cord-010119-t1x9gknd 6271 26 during during IN cord-010119-t1x9gknd 6271 27 species specie NNS cord-010119-t1x9gknd 6271 28 evolution evolution NN cord-010119-t1x9gknd 6271 29 . . . cord-010119-t1x9gknd 6272 1 Conclusion conclusion NN cord-010119-t1x9gknd 6272 2 : : : cord-010119-t1x9gknd 6273 1 Genetic genetic JJ cord-010119-t1x9gknd 6273 2 alterations alteration NNS cord-010119-t1x9gknd 6273 3 , , , cord-010119-t1x9gknd 6273 4 such such JJ cord-010119-t1x9gknd 6273 5 as as IN cord-010119-t1x9gknd 6273 6 deletions deletion NNS cord-010119-t1x9gknd 6273 7 and and CC cord-010119-t1x9gknd 6273 8 duplications duplication NNS cord-010119-t1x9gknd 6273 9 , , , cord-010119-t1x9gknd 6273 10 are be VBP cord-010119-t1x9gknd 6273 11 known know VBN cord-010119-t1x9gknd 6273 12 to to TO cord-010119-t1x9gknd 6273 13 be be VB cord-010119-t1x9gknd 6273 14 prevalent prevalent JJ cord-010119-t1x9gknd 6273 15 at at IN cord-010119-t1x9gknd 6273 16 the the DT cord-010119-t1x9gknd 6273 17 ends end NNS cord-010119-t1x9gknd 6273 18 of of IN cord-010119-t1x9gknd 6273 19 rearranged rearrange VBN cord-010119-t1x9gknd 6273 20 chromosomal chromosomal JJ cord-010119-t1x9gknd 6273 21 fragments fragment NNS cord-010119-t1x9gknd 6273 22 . . . cord-010119-t1x9gknd 6274 1 Therefore therefore RB cord-010119-t1x9gknd 6274 2 , , , cord-010119-t1x9gknd 6274 3 the the DT cord-010119-t1x9gknd 6274 4 species species NN cord-010119-t1x9gknd 6274 5 - - HYPH cord-010119-t1x9gknd 6274 6 dependent dependent JJ cord-010119-t1x9gknd 6274 7 divergence divergence NN cord-010119-t1x9gknd 6274 8 and and CC cord-010119-t1x9gknd 6274 9 polymorphism polymorphism NN cord-010119-t1x9gknd 6274 10 within within IN cord-010119-t1x9gknd 6274 11 species specie NNS cord-010119-t1x9gknd 6274 12 of of IN cord-010119-t1x9gknd 6274 13 those those DT cord-010119-t1x9gknd 6274 14 clinically clinically RB cord-010119-t1x9gknd 6274 15 important important JJ cord-010119-t1x9gknd 6274 16 glycosyltransferase glycosyltransferase NN cord-010119-t1x9gknd 6274 17 genes gene NNS cord-010119-t1x9gknd 6274 18 may may MD cord-010119-t1x9gknd 6274 19 have have VB cord-010119-t1x9gknd 6274 20 been be VBN cord-010119-t1x9gknd 6274 21 resulted result VBN cord-010119-t1x9gknd 6274 22 , , , cord-010119-t1x9gknd 6274 23 at at IN cord-010119-t1x9gknd 6274 24 least least JJS cord-010119-t1x9gknd 6274 25 partially partially RB cord-010119-t1x9gknd 6274 26 , , , cord-010119-t1x9gknd 6274 27 from from IN cord-010119-t1x9gknd 6274 28 unstable unstable JJ cord-010119-t1x9gknd 6274 29 chromosomal chromosomal JJ cord-010119-t1x9gknd 6274 30 structures structure NNS cord-010119-t1x9gknd 6274 31 neighboring neighbor VBG cord-010119-t1x9gknd 6274 32 those those DT cord-010119-t1x9gknd 6274 33 genes gene NNS cord-010119-t1x9gknd 6274 34 . . . cord-010119-t1x9gknd 6275 1 Alloimmunization Alloimmunization NNP cord-010119-t1x9gknd 6275 2 Despite despite IN cord-010119-t1x9gknd 6275 3 Phenotype Phenotype NNP cord-010119-t1x9gknd 6275 4 Matching match VBG cord-010119-t1x9gknd 6275 5 in in IN cord-010119-t1x9gknd 6275 6 a a DT cord-010119-t1x9gknd 6275 7 Patient patient NN cord-010119-t1x9gknd 6275 8 with with IN cord-010119-t1x9gknd 6275 9 Sickle Sickle NNP cord-010119-t1x9gknd 6275 10 Cell Cell NNP cord-010119-t1x9gknd 6275 11 Disease Disease NNP cord-010119-t1x9gknd 6275 12 and and CC cord-010119-t1x9gknd 6275 13 a a DT cord-010119-t1x9gknd 6275 14 Complex Complex NNP cord-010119-t1x9gknd 6275 15 RHCE RHCE NNP cord-010119-t1x9gknd 6275 16 Genotype Genotype NNP cord-010119-t1x9gknd 6275 17 Jessica Jessica NNP cord-010119-t1x9gknd 6275 18 Kneib Kneib NNP cord-010119-t1x9gknd 6275 19 * * NFP cord-010119-t1x9gknd 6275 20 and and CC cord-010119-t1x9gknd 6275 21 Emily Emily NNP cord-010119-t1x9gknd 6275 22 Coberly Coberly NNP cord-010119-t1x9gknd 6275 23 . . . cord-010119-t1x9gknd 6276 1 University University NNP cord-010119-t1x9gknd 6276 2 of of IN cord-010119-t1x9gknd 6276 3 Missouri Missouri NNP cord-010119-t1x9gknd 6276 4 Health Health NNP cord-010119-t1x9gknd 6276 5 Care Care NNP cord-010119-t1x9gknd 6276 6 Background Background NNP cord-010119-t1x9gknd 6276 7 / / SYM cord-010119-t1x9gknd 6276 8 Case Case NNP cord-010119-t1x9gknd 6276 9 Studies Studies NNPS cord-010119-t1x9gknd 6276 10 : : : cord-010119-t1x9gknd 6276 11 Red red JJ cord-010119-t1x9gknd 6276 12 blood blood NN cord-010119-t1x9gknd 6276 13 cell cell NN cord-010119-t1x9gknd 6276 14 transfusion transfusion NN cord-010119-t1x9gknd 6276 15 plays play VBZ cord-010119-t1x9gknd 6276 16 an an DT cord-010119-t1x9gknd 6276 17 important important JJ cord-010119-t1x9gknd 6276 18 role role NN cord-010119-t1x9gknd 6276 19 in in IN cord-010119-t1x9gknd 6276 20 the the DT cord-010119-t1x9gknd 6276 21 treatment treatment NN cord-010119-t1x9gknd 6276 22 of of IN cord-010119-t1x9gknd 6276 23 patients patient NNS cord-010119-t1x9gknd 6276 24 with with IN cord-010119-t1x9gknd 6276 25 sickle sickle NN cord-010119-t1x9gknd 6276 26 cell cell NN cord-010119-t1x9gknd 6276 27 disease disease NN cord-010119-t1x9gknd 6276 28 . . . cord-010119-t1x9gknd 6277 1 Sickle sickle NN cord-010119-t1x9gknd 6277 2 cell cell NN cord-010119-t1x9gknd 6277 3 patients patient NNS cord-010119-t1x9gknd 6277 4 have have VBP cord-010119-t1x9gknd 6277 5 a a DT cord-010119-t1x9gknd 6277 6 significantly significantly RB cord-010119-t1x9gknd 6277 7 increased increase VBN cord-010119-t1x9gknd 6277 8 risk risk NN cord-010119-t1x9gknd 6277 9 of of IN cord-010119-t1x9gknd 6277 10 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6277 11 compared compare VBN cord-010119-t1x9gknd 6277 12 to to IN cord-010119-t1x9gknd 6277 13 the the DT cord-010119-t1x9gknd 6277 14 general general JJ cord-010119-t1x9gknd 6277 15 population population NN cord-010119-t1x9gknd 6277 16 , , , cord-010119-t1x9gknd 6277 17 and and CC cord-010119-t1x9gknd 6277 18 the the DT cord-010119-t1x9gknd 6277 19 standard standard NN cord-010119-t1x9gknd 6277 20 of of IN cord-010119-t1x9gknd 6277 21 care care NN cord-010119-t1x9gknd 6277 22 is be VBZ cord-010119-t1x9gknd 6277 23 to to TO cord-010119-t1x9gknd 6277 24 provide provide VB cord-010119-t1x9gknd 6277 25 phenotypically phenotypically RB cord-010119-t1x9gknd 6277 26 matched match VBN cord-010119-t1x9gknd 6277 27 units unit NNS cord-010119-t1x9gknd 6277 28 for for IN cord-010119-t1x9gknd 6277 29 at at IN cord-010119-t1x9gknd 6277 30 least least JJS cord-010119-t1x9gknd 6277 31 C c NN cord-010119-t1x9gknd 6277 32 , , , cord-010119-t1x9gknd 6277 33 E E NNP cord-010119-t1x9gknd 6277 34 , , , cord-010119-t1x9gknd 6277 35 and and CC cord-010119-t1x9gknd 6277 36 K1 K1 NNP cord-010119-t1x9gknd 6277 37 antigens antigen NNS cord-010119-t1x9gknd 6277 38 to to TO cord-010119-t1x9gknd 6277 39 reduce reduce VB cord-010119-t1x9gknd 6277 40 this this DT cord-010119-t1x9gknd 6277 41 risk risk NN cord-010119-t1x9gknd 6277 42 . . . cord-010119-t1x9gknd 6278 1 Unfortunately unfortunately RB cord-010119-t1x9gknd 6278 2 , , , cord-010119-t1x9gknd 6278 3 the the DT cord-010119-t1x9gknd 6278 4 genotype genotype NN cord-010119-t1x9gknd 6278 5 and and CC cord-010119-t1x9gknd 6278 6 true true JJ cord-010119-t1x9gknd 6278 7 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6278 8 risk risk NN cord-010119-t1x9gknd 6278 9 may may MD cord-010119-t1x9gknd 6278 10 not not RB cord-010119-t1x9gknd 6278 11 always always RB cord-010119-t1x9gknd 6278 12 be be VB cord-010119-t1x9gknd 6278 13 accurately accurately RB cord-010119-t1x9gknd 6278 14 represented represent VBN cord-010119-t1x9gknd 6278 15 by by IN cord-010119-t1x9gknd 6278 16 the the DT cord-010119-t1x9gknd 6278 17 red red JJ cord-010119-t1x9gknd 6278 18 blood blood NN cord-010119-t1x9gknd 6278 19 cell cell NN cord-010119-t1x9gknd 6278 20 phenotype phenotype NN cord-010119-t1x9gknd 6278 21 , , , cord-010119-t1x9gknd 6278 22 particularly particularly RB cord-010119-t1x9gknd 6278 23 in in IN cord-010119-t1x9gknd 6278 24 patients patient NNS cord-010119-t1x9gknd 6278 25 with with IN cord-010119-t1x9gknd 6278 26 complex complex JJ cord-010119-t1x9gknd 6278 27 partial partial JJ cord-010119-t1x9gknd 6278 28 RHCE RHCE NNP cord-010119-t1x9gknd 6278 29 variants variant NNS cord-010119-t1x9gknd 6278 30 . . . cord-010119-t1x9gknd 6279 1 Study Study NNP cord-010119-t1x9gknd 6279 2 Design Design NNP cord-010119-t1x9gknd 6279 3 / / SYM cord-010119-t1x9gknd 6279 4 Method method NN cord-010119-t1x9gknd 6279 5 : : : cord-010119-t1x9gknd 6280 1 A a DT cord-010119-t1x9gknd 6280 2 14 14 CD cord-010119-t1x9gknd 6280 3 year year NN cord-010119-t1x9gknd 6280 4 old old JJ cord-010119-t1x9gknd 6280 5 female female NN cord-010119-t1x9gknd 6280 6 with with IN cord-010119-t1x9gknd 6280 7 a a DT cord-010119-t1x9gknd 6280 8 history history NN cord-010119-t1x9gknd 6280 9 of of IN cord-010119-t1x9gknd 6280 10 sickle sickle NN cord-010119-t1x9gknd 6280 11 cell cell NN cord-010119-t1x9gknd 6280 12 disease disease NN cord-010119-t1x9gknd 6280 13 , , , cord-010119-t1x9gknd 6280 14 stroke stroke NN cord-010119-t1x9gknd 6280 15 , , , cord-010119-t1x9gknd 6280 16 and and CC cord-010119-t1x9gknd 6280 17 iron iron NN cord-010119-t1x9gknd 6280 18 overload overload NN cord-010119-t1x9gknd 6280 19 presented present VBN cord-010119-t1x9gknd 6280 20 for for IN cord-010119-t1x9gknd 6280 21 routine routine JJ cord-010119-t1x9gknd 6280 22 exchange exchange NN cord-010119-t1x9gknd 6280 23 transfusion transfusion NN cord-010119-t1x9gknd 6280 24 . . . cord-010119-t1x9gknd 6281 1 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 6281 2 2017 2017 CD cord-010119-t1x9gknd 6281 3 Vol Vol NNP cord-010119-t1x9gknd 6281 4 . . . cord-010119-t1x9gknd 6282 1 57 57 CD cord-010119-t1x9gknd 6282 2 Supplement supplement NN cord-010119-t1x9gknd 6282 3 S3 s3 NN cord-010119-t1x9gknd 6283 1 The the DT cord-010119-t1x9gknd 6283 2 patient patient NN cord-010119-t1x9gknd 6283 3 's 's POS cord-010119-t1x9gknd 6283 4 blood blood NN cord-010119-t1x9gknd 6283 5 type type NN cord-010119-t1x9gknd 6283 6 was be VBD cord-010119-t1x9gknd 6283 7 O o UH cord-010119-t1x9gknd 6283 8 positive positive JJ cord-010119-t1x9gknd 6283 9 and and CC cord-010119-t1x9gknd 6283 10 her -PRON- PRP$ cord-010119-t1x9gknd 6283 11 red red JJ cord-010119-t1x9gknd 6283 12 cells cell NNS cord-010119-t1x9gknd 6283 13 had have VBD cord-010119-t1x9gknd 6283 14 been be VBN cord-010119-t1x9gknd 6283 15 previously previously RB cord-010119-t1x9gknd 6283 16 phenotyped phenotype VBN cord-010119-t1x9gknd 6283 17 as as IN cord-010119-t1x9gknd 6283 18 C- C- NNP cord-010119-t1x9gknd 6283 19 , , , cord-010119-t1x9gknd 6283 20 c1 c1 NNP cord-010119-t1x9gknd 6283 21 , , , cord-010119-t1x9gknd 6283 22 E- E- NNP cord-010119-t1x9gknd 6283 23 , , , cord-010119-t1x9gknd 6283 24 e1 e1 NN cord-010119-t1x9gknd 6283 25 and and CC cord-010119-t1x9gknd 6283 26 K1- k1- NN cord-010119-t1x9gknd 6283 27 . . . cord-010119-t1x9gknd 6284 1 An an DT cord-010119-t1x9gknd 6284 2 antibody antibody NN cord-010119-t1x9gknd 6284 3 screen screen NN cord-010119-t1x9gknd 6284 4 was be VBD cord-010119-t1x9gknd 6284 5 positive positive JJ cord-010119-t1x9gknd 6284 6 , , , cord-010119-t1x9gknd 6284 7 and and CC cord-010119-t1x9gknd 6284 8 antibodies antibody NNS cord-010119-t1x9gknd 6284 9 against against IN cord-010119-t1x9gknd 6284 10 C C NNP cord-010119-t1x9gknd 6284 11 and and CC cord-010119-t1x9gknd 6284 12 e e NN cord-010119-t1x9gknd 6284 13 antigens antigen NNS cord-010119-t1x9gknd 6284 14 were be VBD cord-010119-t1x9gknd 6284 15 identified identify VBN cord-010119-t1x9gknd 6284 16 in in IN cord-010119-t1x9gknd 6284 17 the the DT cord-010119-t1x9gknd 6284 18 plasma plasma NN cord-010119-t1x9gknd 6284 19 . . . cord-010119-t1x9gknd 6285 1 The the DT cord-010119-t1x9gknd 6285 2 patient patient NN cord-010119-t1x9gknd 6285 3 had have VBD cord-010119-t1x9gknd 6285 4 only only RB cord-010119-t1x9gknd 6285 5 received receive VBN cord-010119-t1x9gknd 6285 6 phenotypically phenotypically RB cord-010119-t1x9gknd 6285 7 matched match VBN cord-010119-t1x9gknd 6285 8 units unit NNS cord-010119-t1x9gknd 6285 9 negative negative JJ cord-010119-t1x9gknd 6285 10 for for IN cord-010119-t1x9gknd 6285 11 C c NN cord-010119-t1x9gknd 6285 12 and and CC cord-010119-t1x9gknd 6285 13 E e NN cord-010119-t1x9gknd 6285 14 antigens antigen NNS cord-010119-t1x9gknd 6285 15 for for IN cord-010119-t1x9gknd 6285 16 all all DT cord-010119-t1x9gknd 6285 17 previous previous JJ cord-010119-t1x9gknd 6285 18 transfusions transfusion NNS cord-010119-t1x9gknd 6285 19 at at IN cord-010119-t1x9gknd 6285 20 our -PRON- PRP$ cord-010119-t1x9gknd 6285 21 institution institution NN cord-010119-t1x9gknd 6285 22 , , , cord-010119-t1x9gknd 6285 23 based base VBN cord-010119-t1x9gknd 6285 24 on on IN cord-010119-t1x9gknd 6285 25 her -PRON- PRP$ cord-010119-t1x9gknd 6285 26 known known JJ cord-010119-t1x9gknd 6285 27 red red JJ cord-010119-t1x9gknd 6285 28 blood blood NN cord-010119-t1x9gknd 6285 29 cell cell NN cord-010119-t1x9gknd 6285 30 phenotype phenotype NN cord-010119-t1x9gknd 6285 31 . . . cord-010119-t1x9gknd 6286 1 Blood blood NN cord-010119-t1x9gknd 6286 2 samples sample NNS cord-010119-t1x9gknd 6286 3 were be VBD cord-010119-t1x9gknd 6286 4 sent send VBN cord-010119-t1x9gknd 6286 5 to to IN cord-010119-t1x9gknd 6286 6 a a DT cord-010119-t1x9gknd 6286 7 reference reference NN cord-010119-t1x9gknd 6286 8 laboratory laboratory NN cord-010119-t1x9gknd 6286 9 for for IN cord-010119-t1x9gknd 6286 10 molecular molecular JJ cord-010119-t1x9gknd 6286 11 testing testing NN cord-010119-t1x9gknd 6286 12 to to TO cord-010119-t1x9gknd 6286 13 look look VB cord-010119-t1x9gknd 6286 14 for for IN cord-010119-t1x9gknd 6286 15 partial partial JJ cord-010119-t1x9gknd 6286 16 RHCE RHCE NNP cord-010119-t1x9gknd 6286 17 variants variant NNS cord-010119-t1x9gknd 6286 18 that that WDT cord-010119-t1x9gknd 6286 19 might may MD cord-010119-t1x9gknd 6286 20 explain explain VB cord-010119-t1x9gknd 6286 21 the the DT cord-010119-t1x9gknd 6286 22 antibody antibody NN cord-010119-t1x9gknd 6286 23 development development NN cord-010119-t1x9gknd 6286 24 . . . cord-010119-t1x9gknd 6287 1 Results/ Results/ . cord-010119-t1x9gknd 6288 1 Finding finding NN cord-010119-t1x9gknd 6288 2 : : : cord-010119-t1x9gknd 6289 1 Molecular molecular JJ cord-010119-t1x9gknd 6289 2 testing testing NN cord-010119-t1x9gknd 6289 3 was be VBD cord-010119-t1x9gknd 6289 4 performed perform VBN cord-010119-t1x9gknd 6289 5 to to TO cord-010119-t1x9gknd 6289 6 reveal reveal VB cord-010119-t1x9gknd 6289 7 the the DT cord-010119-t1x9gknd 6289 8 presence presence NN cord-010119-t1x9gknd 6289 9 of of IN cord-010119-t1x9gknd 6289 10 two two CD cord-010119-t1x9gknd 6289 11 different different JJ cord-010119-t1x9gknd 6289 12 partial partial JJ cord-010119-t1x9gknd 6289 13 RHCE RHCE NNP cord-010119-t1x9gknd 6289 14 alleles allele NNS cord-010119-t1x9gknd 6289 15 , , , cord-010119-t1x9gknd 6289 16 resulting result VBG cord-010119-t1x9gknd 6289 17 in in IN cord-010119-t1x9gknd 6289 18 a a DT cord-010119-t1x9gknd 6289 19 predicted predict VBN cord-010119-t1x9gknd 6289 20 phenotype phenotype NN cord-010119-t1x9gknd 6289 21 of of IN cord-010119-t1x9gknd 6289 22 D1 d1 NN cord-010119-t1x9gknd 6289 23 , , , cord-010119-t1x9gknd 6289 24 C- C- NNP cord-010119-t1x9gknd 6289 25 , , , cord-010119-t1x9gknd 6289 26 E- E- NNP cord-010119-t1x9gknd 6289 27 , , , cord-010119-t1x9gknd 6289 28 partial partial JJ cord-010119-t1x9gknd 6289 29 c1 c1 NN cord-010119-t1x9gknd 6289 30 , , , cord-010119-t1x9gknd 6289 31 partial partial JJ cord-010119-t1x9gknd 6289 32 e1 e1 NN cord-010119-t1x9gknd 6289 33 . . . cord-010119-t1x9gknd 6290 1 The the DT cord-010119-t1x9gknd 6290 2 probable probable JJ cord-010119-t1x9gknd 6290 3 RHCE RHCE NNP cord-010119-t1x9gknd 6290 4 genotype genotype NN cord-010119-t1x9gknd 6290 5 , , , cord-010119-t1x9gknd 6290 6 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 6290 7 - - HYPH cord-010119-t1x9gknd 6290 8 JAL JAL NNP cord-010119-t1x9gknd 6290 9 / / SYM cord-010119-t1x9gknd 6290 10 RHCE*ce733 RHCE*ce733 NNP cord-010119-t1x9gknd 6290 11 G G NNP cord-010119-t1x9gknd 6290 12 , , , cord-010119-t1x9gknd 6290 13 results result NNS cord-010119-t1x9gknd 6290 14 in in IN cord-010119-t1x9gknd 6290 15 partial partial JJ cord-010119-t1x9gknd 6290 16 expression expression NN cord-010119-t1x9gknd 6290 17 of of IN cord-010119-t1x9gknd 6290 18 both both DT cord-010119-t1x9gknd 6290 19 c c NN cord-010119-t1x9gknd 6290 20 and and CC cord-010119-t1x9gknd 6290 21 e e NN cord-010119-t1x9gknd 6290 22 antigens antigen NNS cord-010119-t1x9gknd 6290 23 . . . cord-010119-t1x9gknd 6291 1 In in IN cord-010119-t1x9gknd 6291 2 addition addition NN cord-010119-t1x9gknd 6291 3 to to IN cord-010119-t1x9gknd 6291 4 the the DT cord-010119-t1x9gknd 6291 5 known know VBN cord-010119-t1x9gknd 6291 6 risk risk NN cord-010119-t1x9gknd 6291 7 of of IN cord-010119-t1x9gknd 6291 8 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6291 9 against against IN cord-010119-t1x9gknd 6291 10 the the DT cord-010119-t1x9gknd 6291 11 absent absent JJ cord-010119-t1x9gknd 6291 12 C c NN cord-010119-t1x9gknd 6291 13 and and CC cord-010119-t1x9gknd 6291 14 E e NN cord-010119-t1x9gknd 6291 15 antigens antigen NNS cord-010119-t1x9gknd 6291 16 , , , cord-010119-t1x9gknd 6291 17 this this DT cord-010119-t1x9gknd 6291 18 result result NN cord-010119-t1x9gknd 6291 19 indicates indicate VBZ cord-010119-t1x9gknd 6291 20 that that IN cord-010119-t1x9gknd 6291 21 the the DT cord-010119-t1x9gknd 6291 22 patient patient NN cord-010119-t1x9gknd 6291 23 is be VBZ cord-010119-t1x9gknd 6291 24 also also RB cord-010119-t1x9gknd 6291 25 capable capable JJ cord-010119-t1x9gknd 6291 26 of of IN cord-010119-t1x9gknd 6291 27 forming form VBG cord-010119-t1x9gknd 6291 28 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6291 29 against against IN cord-010119-t1x9gknd 6291 30 the the DT cord-010119-t1x9gknd 6291 31 absent absent JJ cord-010119-t1x9gknd 6291 32 portions portion NNS cord-010119-t1x9gknd 6291 33 of of IN cord-010119-t1x9gknd 6291 34 both both DT cord-010119-t1x9gknd 6291 35 c c NN cord-010119-t1x9gknd 6291 36 and and CC cord-010119-t1x9gknd 6291 37 e e NN cord-010119-t1x9gknd 6291 38 antigens antigen NNS cord-010119-t1x9gknd 6291 39 . . . cord-010119-t1x9gknd 6292 1 Based base VBN cord-010119-t1x9gknd 6292 2 on on IN cord-010119-t1x9gknd 6292 3 these these DT cord-010119-t1x9gknd 6292 4 results result NNS cord-010119-t1x9gknd 6292 5 , , , cord-010119-t1x9gknd 6292 6 the the DT cord-010119-t1x9gknd 6292 7 patient patient NN cord-010119-t1x9gknd 6292 8 's 's POS cord-010119-t1x9gknd 6292 9 anti anti NNS cord-010119-t1x9gknd 6292 10 - - NN cord-010119-t1x9gknd 6292 11 e e JJ cord-010119-t1x9gknd 6292 12 was be VBD cord-010119-t1x9gknd 6292 13 determined determine VBN cord-010119-t1x9gknd 6292 14 to to TO cord-010119-t1x9gknd 6292 15 be be VB cord-010119-t1x9gknd 6292 16 an an DT cord-010119-t1x9gknd 6292 17 alloantibody alloantibody NN cord-010119-t1x9gknd 6292 18 and and CC cord-010119-t1x9gknd 6292 19 not not RB cord-010119-t1x9gknd 6292 20 an an DT cord-010119-t1x9gknd 6292 21 autoantibody autoantibody NN cord-010119-t1x9gknd 6292 22 . . . cord-010119-t1x9gknd 6293 1 Conclusion conclusion NN cord-010119-t1x9gknd 6293 2 : : : cord-010119-t1x9gknd 6294 1 Although although IN cord-010119-t1x9gknd 6294 2 phenotypically phenotypically RB cord-010119-t1x9gknd 6294 3 matched match VBN cord-010119-t1x9gknd 6294 4 units unit NNS cord-010119-t1x9gknd 6294 5 are be VBP cord-010119-t1x9gknd 6294 6 standard standard JJ cord-010119-t1x9gknd 6294 7 of of IN cord-010119-t1x9gknd 6294 8 care care NN cord-010119-t1x9gknd 6294 9 for for IN cord-010119-t1x9gknd 6294 10 patients patient NNS cord-010119-t1x9gknd 6294 11 with with IN cord-010119-t1x9gknd 6294 12 sickle sickle NN cord-010119-t1x9gknd 6294 13 cell cell NN cord-010119-t1x9gknd 6294 14 disease disease NN cord-010119-t1x9gknd 6294 15 , , , cord-010119-t1x9gknd 6294 16 the the DT cord-010119-t1x9gknd 6294 17 red red JJ cord-010119-t1x9gknd 6294 18 blood blood NN cord-010119-t1x9gknd 6294 19 cell cell NN cord-010119-t1x9gknd 6294 20 phenotype phenotype NN cord-010119-t1x9gknd 6294 21 may may MD cord-010119-t1x9gknd 6294 22 not not RB cord-010119-t1x9gknd 6294 23 accurately accurately RB cord-010119-t1x9gknd 6294 24 represent represent VB cord-010119-t1x9gknd 6294 25 the the DT cord-010119-t1x9gknd 6294 26 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6294 27 risk risk NN cord-010119-t1x9gknd 6294 28 in in IN cord-010119-t1x9gknd 6294 29 patients patient NNS cord-010119-t1x9gknd 6294 30 with with IN cord-010119-t1x9gknd 6294 31 complex complex JJ cord-010119-t1x9gknd 6294 32 partial partial JJ cord-010119-t1x9gknd 6294 33 RHCE RHCE NNP cord-010119-t1x9gknd 6294 34 genotypes genotype NNS cord-010119-t1x9gknd 6294 35 . . . cord-010119-t1x9gknd 6295 1 In in IN cord-010119-t1x9gknd 6295 2 this this DT cord-010119-t1x9gknd 6295 3 case case NN cord-010119-t1x9gknd 6295 4 , , , cord-010119-t1x9gknd 6295 5 molecular molecular JJ cord-010119-t1x9gknd 6295 6 testing testing NN cord-010119-t1x9gknd 6295 7 confirmed confirm VBD cord-010119-t1x9gknd 6295 8 that that IN cord-010119-t1x9gknd 6295 9 the the DT cord-010119-t1x9gknd 6295 10 patient patient NN cord-010119-t1x9gknd 6295 11 is be VBZ cord-010119-t1x9gknd 6295 12 at at IN cord-010119-t1x9gknd 6295 13 risk risk NN cord-010119-t1x9gknd 6295 14 of of IN cord-010119-t1x9gknd 6295 15 developing develop VBG cord-010119-t1x9gknd 6295 16 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6295 17 against against IN cord-010119-t1x9gknd 6295 18 C C NNP cord-010119-t1x9gknd 6295 19 , , , cord-010119-t1x9gknd 6295 20 c c NNP cord-010119-t1x9gknd 6295 21 , , , cord-010119-t1x9gknd 6295 22 E E NNP cord-010119-t1x9gknd 6295 23 , , , cord-010119-t1x9gknd 6295 24 and and CC cord-010119-t1x9gknd 6295 25 e e LS cord-010119-t1x9gknd 6295 26 antigens antigen NNS cord-010119-t1x9gknd 6295 27 . . . cord-010119-t1x9gknd 6296 1 As as IN cord-010119-t1x9gknd 6296 2 the the DT cord-010119-t1x9gknd 6296 3 patient patient NN cord-010119-t1x9gknd 6296 4 had have VBD cord-010119-t1x9gknd 6296 5 already already RB cord-010119-t1x9gknd 6296 6 made make VBN cord-010119-t1x9gknd 6296 7 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6296 8 against against IN cord-010119-t1x9gknd 6296 9 C C NNP cord-010119-t1x9gknd 6296 10 and and CC cord-010119-t1x9gknd 6296 11 e e NN cord-010119-t1x9gknd 6296 12 antigens antigen NNS cord-010119-t1x9gknd 6296 13 , , , cord-010119-t1x9gknd 6296 14 it -PRON- PRP cord-010119-t1x9gknd 6296 15 was be VBD cord-010119-t1x9gknd 6296 16 determined determine VBN cord-010119-t1x9gknd 6296 17 that that IN cord-010119-t1x9gknd 6296 18 she -PRON- PRP cord-010119-t1x9gknd 6296 19 would would MD cord-010119-t1x9gknd 6296 20 require require VB cord-010119-t1x9gknd 6296 21 units unit NNS cord-010119-t1x9gknd 6296 22 that that WDT cord-010119-t1x9gknd 6296 23 were be VBD cord-010119-t1x9gknd 6296 24 molecularly molecularly RB cord-010119-t1x9gknd 6296 25 matched match VBN cord-010119-t1x9gknd 6296 26 to to IN cord-010119-t1x9gknd 6296 27 her -PRON- PRP$ cord-010119-t1x9gknd 6296 28 RHCE RHCE NNP cord-010119-t1x9gknd 6296 29 variants variant NNS cord-010119-t1x9gknd 6296 30 for for IN cord-010119-t1x9gknd 6296 31 all all DT cord-010119-t1x9gknd 6296 32 future future JJ cord-010119-t1x9gknd 6296 33 transfusions transfusion NNS cord-010119-t1x9gknd 6296 34 . . . cord-010119-t1x9gknd 6297 1 This this DT cord-010119-t1x9gknd 6297 2 case case NN cord-010119-t1x9gknd 6297 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 6297 4 that that IN cord-010119-t1x9gknd 6297 5 phenotype phenotype NN cord-010119-t1x9gknd 6297 6 matching match VBG cord-010119-t1x9gknd 6297 7 for for IN cord-010119-t1x9gknd 6297 8 sickle sickle NN cord-010119-t1x9gknd 6297 9 cell cell NN cord-010119-t1x9gknd 6297 10 disease disease NN cord-010119-t1x9gknd 6297 11 patients patient NNS cord-010119-t1x9gknd 6297 12 may may MD cord-010119-t1x9gknd 6297 13 not not RB cord-010119-t1x9gknd 6297 14 be be VB cord-010119-t1x9gknd 6297 15 adequate adequate JJ cord-010119-t1x9gknd 6297 16 to to TO cord-010119-t1x9gknd 6297 17 prevent prevent VB cord-010119-t1x9gknd 6297 18 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6297 19 in in IN cord-010119-t1x9gknd 6297 20 individuals individual NNS cord-010119-t1x9gknd 6297 21 with with IN cord-010119-t1x9gknd 6297 22 partial partial JJ cord-010119-t1x9gknd 6297 23 RHCE RHCE NNP cord-010119-t1x9gknd 6297 24 variants variant NNS cord-010119-t1x9gknd 6297 25 . . . cord-010119-t1x9gknd 6298 1 Altered alter VBN cord-010119-t1x9gknd 6298 2 Splicing splice VBG cord-010119-t1x9gknd 6298 3 in in IN cord-010119-t1x9gknd 6298 4 the the DT cord-010119-t1x9gknd 6298 5 RHD*Weak rhd*weak NN cord-010119-t1x9gknd 6298 6 D D NNP cord-010119-t1x9gknd 6298 7 Type type NN cord-010119-t1x9gknd 6298 8 2 2 CD cord-010119-t1x9gknd 6298 9 Allele allele NN cord-010119-t1x9gknd 6299 1 Associated associate VBN cord-010119-t1x9gknd 6299 2 with with IN cord-010119-t1x9gknd 6299 3 the the DT cord-010119-t1x9gknd 6299 4 Skipping skipping NN cord-010119-t1x9gknd 6299 5 of of IN cord-010119-t1x9gknd 6299 6 Exon Exon NNP cord-010119-t1x9gknd 6299 7 9 9 CD cord-010119-t1x9gknd 6299 8 in in IN cord-010119-t1x9gknd 6299 9 a a DT cord-010119-t1x9gknd 6299 10 Pregnant Pregnant NNP cord-010119-t1x9gknd 6299 11 Woman Woman NNP cord-010119-t1x9gknd 6299 12 and and CC cord-010119-t1x9gknd 6299 13 Her -PRON- PRP$ cord-010119-t1x9gknd 6299 14 Newborn Newborn NNP cord-010119-t1x9gknd 6299 15 Carolina Carolina NNP cord-010119-t1x9gknd 6299 16 Bonet Bonet NNP cord-010119-t1x9gknd 6299 17 Bub Bub NNP cord-010119-t1x9gknd 6300 1 * * NFP cord-010119-t1x9gknd 6300 2 1 1 CD cord-010119-t1x9gknd 6300 3 , , , cord-010119-t1x9gknd 6300 4 Maria Maria NNP cord-010119-t1x9gknd 6300 5 Giselda Giselda NNP cord-010119-t1x9gknd 6300 6 Aravechia Aravechia NNP cord-010119-t1x9gknd 6300 7 1 1 CD cord-010119-t1x9gknd 6300 8 , , , cord-010119-t1x9gknd 6300 9 Thiago Thiago NNP cord-010119-t1x9gknd 6300 10 Costa Costa NNP cord-010119-t1x9gknd 6300 11 1 1 CD cord-010119-t1x9gknd 6300 12 , , , cord-010119-t1x9gknd 6300 13 Marilia Marilia NNP cord-010119-t1x9gknd 6300 14 Sirianni Sirianni NNP cord-010119-t1x9gknd 6300 15 1 1 CD cord-010119-t1x9gknd 6300 16 , , , cord-010119-t1x9gknd 6300 17 Eduardo Eduardo NNP cord-010119-t1x9gknd 6300 18 Bastos Bastos NNP cord-010119-t1x9gknd 6300 19 1 1 CD cord-010119-t1x9gknd 6300 20 , , , cord-010119-t1x9gknd 6300 21 Leandro Leandro NNP cord-010119-t1x9gknd 6300 22 Santos Santos NNP cord-010119-t1x9gknd 6300 23 1 1 CD cord-010119-t1x9gknd 6300 24 , , , cord-010119-t1x9gknd 6300 25 Lilian Lilian NNP cord-010119-t1x9gknd 6300 26 Castilho Castilho NNP cord-010119-t1x9gknd 6300 27 2 2 CD cord-010119-t1x9gknd 6300 28 and and CC cord-010119-t1x9gknd 6300 29 Jos Jos NNP cord-010119-t1x9gknd 6300 30 e e NNP cord-010119-t1x9gknd 6300 31 Kutner Kutner NNP cord-010119-t1x9gknd 6300 32 1 1 CD cord-010119-t1x9gknd 6300 33 . . . cord-010119-t1x9gknd 6301 1 1 1 CD cord-010119-t1x9gknd 6301 2 Hospital Hospital NNP cord-010119-t1x9gknd 6301 3 Israelita Israelita NNP cord-010119-t1x9gknd 6301 4 Albert Albert NNP cord-010119-t1x9gknd 6301 5 Einstein Einstein NNP cord-010119-t1x9gknd 6301 6 , , , cord-010119-t1x9gknd 6301 7 2 2 CD cord-010119-t1x9gknd 6301 8 Hemocentro Hemocentro NNP cord-010119-t1x9gknd 6301 9 Unicamp Unicamp NNP cord-010119-t1x9gknd 6301 10 Background Background NNP cord-010119-t1x9gknd 6301 11 / / SYM cord-010119-t1x9gknd 6301 12 Case Case NNP cord-010119-t1x9gknd 6301 13 Studies Studies NNPS cord-010119-t1x9gknd 6301 14 : : : cord-010119-t1x9gknd 6302 1 RHD*weak RHD*weak NNP cord-010119-t1x9gknd 6302 2 D d NN cord-010119-t1x9gknd 6302 3 type type NN cord-010119-t1x9gknd 6302 4 2 2 CD cord-010119-t1x9gknd 6302 5 is be VBZ cord-010119-t1x9gknd 6302 6 a a DT cord-010119-t1x9gknd 6302 7 variant variant NN cord-010119-t1x9gknd 6302 8 commonly commonly RB cord-010119-t1x9gknd 6302 9 found find VBN cord-010119-t1x9gknd 6302 10 in in IN cord-010119-t1x9gknd 6302 11 Caucasians Caucasians NNPS cord-010119-t1x9gknd 6302 12 associated associate VBN cord-010119-t1x9gknd 6302 13 with with IN cord-010119-t1x9gknd 6302 14 a a DT cord-010119-t1x9gknd 6302 15 weak weak JJ cord-010119-t1x9gknd 6302 16 D d NN cord-010119-t1x9gknd 6302 17 phenotype phenotype NN cord-010119-t1x9gknd 6302 18 . . . cord-010119-t1x9gknd 6303 1 As as IN cord-010119-t1x9gknd 6303 2 previously previously RB cord-010119-t1x9gknd 6303 3 reported report VBN cord-010119-t1x9gknd 6303 4 ( ( -LRB- cord-010119-t1x9gknd 6303 5 Vege vege FW cord-010119-t1x9gknd 6303 6 et et FW cord-010119-t1x9gknd 6303 7 al al NNP cord-010119-t1x9gknd 6303 8 , , , cord-010119-t1x9gknd 6303 9 Transfusion Transfusion NNP cord-010119-t1x9gknd 6303 10 2007 2007 CD cord-010119-t1x9gknd 6303 11 ) ) -RRB- cord-010119-t1x9gknd 6304 1 the the DT cord-010119-t1x9gknd 6304 2 c.1154G c.1154g NN cord-010119-t1x9gknd 6304 3 > > XX cord-010119-t1x9gknd 6304 4 C c NN cord-010119-t1x9gknd 6304 5 change change NN cord-010119-t1x9gknd 6304 6 ( ( -LRB- cord-010119-t1x9gknd 6304 7 p p NN cord-010119-t1x9gknd 6304 8 . . . cord-010119-t1x9gknd 6304 9 G385A G385A NNP cord-010119-t1x9gknd 6304 10 ) ) -RRB- cord-010119-t1x9gknd 6304 11 , , , cord-010119-t1x9gknd 6304 12 which which WDT cord-010119-t1x9gknd 6304 13 characterizes characterize VBZ cord-010119-t1x9gknd 6304 14 the the DT cord-010119-t1x9gknd 6304 15 RHD*weak RHD*weak NNP cord-010119-t1x9gknd 6304 16 D D NNP cord-010119-t1x9gknd 6304 17 type type NN cord-010119-t1x9gknd 6304 18 2 2 CD cord-010119-t1x9gknd 6304 19 allele allele NN cord-010119-t1x9gknd 6304 20 is be VBZ cord-010119-t1x9gknd 6304 21 a a DT cord-010119-t1x9gknd 6304 22 splicing splicing NN cord-010119-t1x9gknd 6304 23 variant variant NN cord-010119-t1x9gknd 6304 24 that that WDT cord-010119-t1x9gknd 6304 25 induces induce VBZ cord-010119-t1x9gknd 6304 26 skipping skip VBG cord-010119-t1x9gknd 6304 27 of of IN cord-010119-t1x9gknd 6304 28 the the DT cord-010119-t1x9gknd 6304 29 whole whole JJ cord-010119-t1x9gknd 6304 30 RHD RHD NNP cord-010119-t1x9gknd 6304 31 exon exon NN cord-010119-t1x9gknd 6304 32 9 9 CD cord-010119-t1x9gknd 6304 33 . . . cord-010119-t1x9gknd 6305 1 We -PRON- PRP cord-010119-t1x9gknd 6305 2 report report VBP cord-010119-t1x9gknd 6305 3 an an DT cord-010119-t1x9gknd 6305 4 altered alter VBN cord-010119-t1x9gknd 6305 5 splicing splicing NN cord-010119-t1x9gknd 6305 6 in in IN cord-010119-t1x9gknd 6305 7 the the DT cord-010119-t1x9gknd 6305 8 RHD*weak RHD*weak NNP cord-010119-t1x9gknd 6305 9 D D NNP cord-010119-t1x9gknd 6305 10 type type NN cord-010119-t1x9gknd 6305 11 2 2 CD cord-010119-t1x9gknd 6305 12 allele allele NN cord-010119-t1x9gknd 6305 13 associated associate VBN cord-010119-t1x9gknd 6305 14 with with IN cord-010119-t1x9gknd 6305 15 the the DT cord-010119-t1x9gknd 6305 16 skipping skipping NN cord-010119-t1x9gknd 6305 17 of of IN cord-010119-t1x9gknd 6305 18 exon exon NN cord-010119-t1x9gknd 6305 19 9 9 CD cord-010119-t1x9gknd 6305 20 in in IN cord-010119-t1x9gknd 6305 21 a a DT cord-010119-t1x9gknd 6305 22 pregnant pregnant JJ cord-010119-t1x9gknd 6305 23 women woman NNS cord-010119-t1x9gknd 6305 24 and and CC cord-010119-t1x9gknd 6305 25 her -PRON- PRP$ cord-010119-t1x9gknd 6305 26 newborn newborn JJ cord-010119-t1x9gknd 6305 27 with with IN cord-010119-t1x9gknd 6305 28 weak weak JJ cord-010119-t1x9gknd 6305 29 D d NN cord-010119-t1x9gknd 6305 30 expression expression NN cord-010119-t1x9gknd 6305 31 . . . cord-010119-t1x9gknd 6306 1 Study Study NNP cord-010119-t1x9gknd 6306 2 Design Design NNP cord-010119-t1x9gknd 6306 3 / / SYM cord-010119-t1x9gknd 6306 4 Method method NN cord-010119-t1x9gknd 6306 5 : : : cord-010119-t1x9gknd 6307 1 The the DT cord-010119-t1x9gknd 6307 2 D d NN cord-010119-t1x9gknd 6307 3 antigen antigen NN cord-010119-t1x9gknd 6307 4 expression expression NN cord-010119-t1x9gknd 6307 5 was be VBD cord-010119-t1x9gknd 6307 6 evaluated evaluate VBN cord-010119-t1x9gknd 6307 7 with with IN cord-010119-t1x9gknd 6307 8 4 4 CD cord-010119-t1x9gknd 6307 9 commercially commercially RB cord-010119-t1x9gknd 6307 10 available available JJ cord-010119-t1x9gknd 6307 11 monoclonal monoclonal JJ cord-010119-t1x9gknd 6307 12 anti anti JJ cord-010119-t1x9gknd 6307 13 - - JJ cord-010119-t1x9gknd 6307 14 D d JJ cord-010119-t1x9gknd 6307 15 reagents reagent NNS cord-010119-t1x9gknd 6307 16 : : : cord-010119-t1x9gknd 6307 17 1 1 CD cord-010119-t1x9gknd 6307 18 blended blended NNP cord-010119-t1x9gknd 6307 19 IgM IgM NNP cord-010119-t1x9gknd 6307 20 / / SYM cord-010119-t1x9gknd 6307 21 IgG IgG NNP cord-010119-t1x9gknd 6307 22 ( ( -LRB- cord-010119-t1x9gknd 6307 23 clones clone NNS cord-010119-t1x9gknd 6307 24 TH-28 TH-28 NNP cord-010119-t1x9gknd 6307 25 / / SYM cord-010119-t1x9gknd 6307 26 MS-26 MS-26 NNP cord-010119-t1x9gknd 6307 27 ) ) -RRB- cord-010119-t1x9gknd 6307 28 , , , cord-010119-t1x9gknd 6307 29 2 2 CD cord-010119-t1x9gknd 6307 30 IgM IgM NNP cord-010119-t1x9gknd 6307 31 ( ( -LRB- cord-010119-t1x9gknd 6307 32 clones clone NNS cord-010119-t1x9gknd 6307 33 MS201 MS201 NNP cord-010119-t1x9gknd 6307 34 and and CC cord-010119-t1x9gknd 6307 35 P3x61 P3x61 NNP cord-010119-t1x9gknd 6307 36 ) ) -RRB- cord-010119-t1x9gknd 6307 37 and and CC cord-010119-t1x9gknd 6307 38 1 1 CD cord-010119-t1x9gknd 6307 39 IgG IgG NNP cord-010119-t1x9gknd 6307 40 ( ( -LRB- cord-010119-t1x9gknd 6307 41 MS26 MS26 NNP cord-010119-t1x9gknd 6307 42 ) ) -RRB- cord-010119-t1x9gknd 6307 43 in in IN cord-010119-t1x9gknd 6307 44 tube tube NN cord-010119-t1x9gknd 6307 45 and and CC cord-010119-t1x9gknd 6307 46 on on IN cord-010119-t1x9gknd 6307 47 gel gel NN cord-010119-t1x9gknd 6307 48 cards card NNS cord-010119-t1x9gknd 6307 49 . . . cord-010119-t1x9gknd 6308 1 C C NNP cord-010119-t1x9gknd 6308 2 , , , cord-010119-t1x9gknd 6308 3 c c NNP cord-010119-t1x9gknd 6308 4 , , , cord-010119-t1x9gknd 6308 5 E E NNP cord-010119-t1x9gknd 6308 6 and and CC cord-010119-t1x9gknd 6308 7 e e NN cord-010119-t1x9gknd 6308 8 phenotyping phenotyping NN cord-010119-t1x9gknd 6308 9 were be VBD cord-010119-t1x9gknd 6308 10 performed perform VBN cord-010119-t1x9gknd 6308 11 in in IN cord-010119-t1x9gknd 6308 12 gel gel NN cord-010119-t1x9gknd 6308 13 . . . cord-010119-t1x9gknd 6309 1 RHD RHD NNP cord-010119-t1x9gknd 6309 2 genotyping genotyping NN cord-010119-t1x9gknd 6309 3 was be VBD cord-010119-t1x9gknd 6309 4 performed perform VBN cord-010119-t1x9gknd 6309 5 with with IN cord-010119-t1x9gknd 6309 6 the the DT cord-010119-t1x9gknd 6309 7 RHD RHD NNP cord-010119-t1x9gknd 6309 8 BeadChip BeadChip NNP cord-010119-t1x9gknd 6309 9 platform platform NN cord-010119-t1x9gknd 6309 10 from from IN cord-010119-t1x9gknd 6309 11 Immucor Immucor NNP cord-010119-t1x9gknd 6309 12 . . . cord-010119-t1x9gknd 6310 1 Direct direct JJ cord-010119-t1x9gknd 6310 2 automated automate VBN cord-010119-t1x9gknd 6310 3 sequencing sequencing NN cord-010119-t1x9gknd 6310 4 of of IN cord-010119-t1x9gknd 6310 5 the the DT cord-010119-t1x9gknd 6310 6 10 10 CD cord-010119-t1x9gknd 6310 7 RHD RHD NNP cord-010119-t1x9gknd 6310 8 exons exon NNS cord-010119-t1x9gknd 6310 9 and and CC cord-010119-t1x9gknd 6310 10 flanking flanking JJ cord-010119-t1x9gknd 6310 11 intron intron NN cord-010119-t1x9gknd 6310 12 regions region NNS cord-010119-t1x9gknd 6310 13 was be VBD cord-010119-t1x9gknd 6310 14 performed perform VBN cord-010119-t1x9gknd 6310 15 by by IN cord-010119-t1x9gknd 6310 16 the the DT cord-010119-t1x9gknd 6310 17 Sanger Sanger NNP cord-010119-t1x9gknd 6310 18 dideoxy dideoxy NN cord-010119-t1x9gknd 6310 19 method method NN cord-010119-t1x9gknd 6310 20 . . . cord-010119-t1x9gknd 6311 1 Results/ Results/ . cord-010119-t1x9gknd 6312 1 Finding find VBG cord-010119-t1x9gknd 6312 2 : : : cord-010119-t1x9gknd 6312 3 Both both DT cord-010119-t1x9gknd 6312 4 pregnant pregnant JJ cord-010119-t1x9gknd 6312 5 women woman NNS cord-010119-t1x9gknd 6312 6 and and CC cord-010119-t1x9gknd 6312 7 newborn newborn JJ cord-010119-t1x9gknd 6312 8 samples sample NNS cord-010119-t1x9gknd 6312 9 were be VBD cord-010119-t1x9gknd 6312 10 phenotyped phenotype VBN cord-010119-t1x9gknd 6312 11 as as IN cord-010119-t1x9gknd 6312 12 D1 D1 NNP cord-010119-t1x9gknd 6312 13 w w NNP cord-010119-t1x9gknd 6312 14 C C NNP cord-010119-t1x9gknd 6312 15 - - HYPH cord-010119-t1x9gknd 6312 16 c1E1e1 c1e1e1 NN cord-010119-t1x9gknd 6312 17 . . . cord-010119-t1x9gknd 6313 1 The the DT cord-010119-t1x9gknd 6313 2 samples sample NNS cord-010119-t1x9gknd 6313 3 showed show VBD cord-010119-t1x9gknd 6313 4 weak weak JJ cord-010119-t1x9gknd 6313 5 hemagglutination hemagglutination NN cord-010119-t1x9gknd 6313 6 reactions reaction NNS cord-010119-t1x9gknd 6313 7 ( ( -LRB- cord-010119-t1x9gknd 6313 8 11/21 11/21 CD cord-010119-t1x9gknd 6313 9 ) ) -RRB- cord-010119-t1x9gknd 6313 10 with with IN cord-010119-t1x9gknd 6313 11 all all DT cord-010119-t1x9gknd 6313 12 anti anti JJ cord-010119-t1x9gknd 6313 13 - - JJ cord-010119-t1x9gknd 6313 14 D d JJ cord-010119-t1x9gknd 6313 15 clones clone NNS cord-010119-t1x9gknd 6313 16 used use VBN cord-010119-t1x9gknd 6313 17 . . . cord-010119-t1x9gknd 6314 1 RHD RHD NNP cord-010119-t1x9gknd 6314 2 Beadchip Beadchip NNP cord-010119-t1x9gknd 6314 3 results result NNS cord-010119-t1x9gknd 6314 4 showed show VBD cord-010119-t1x9gknd 6314 5 the the DT cord-010119-t1x9gknd 6314 6 LS ls NN cord-010119-t1x9gknd 6314 7 * * NFP cord-010119-t1x9gknd 6314 8 signal signal NN cord-010119-t1x9gknd 6314 9 indicating indicate VBG cord-010119-t1x9gknd 6314 10 a a DT cord-010119-t1x9gknd 6314 11 possible possible JJ cord-010119-t1x9gknd 6314 12 deletion deletion NN cord-010119-t1x9gknd 6314 13 of of IN cord-010119-t1x9gknd 6314 14 exon exon NN cord-010119-t1x9gknd 6314 15 9 9 CD cord-010119-t1x9gknd 6314 16 in in IN cord-010119-t1x9gknd 6314 17 both both CC cord-010119-t1x9gknd 6314 18 DNA dna NN cord-010119-t1x9gknd 6314 19 samples sample NNS cord-010119-t1x9gknd 6314 20 . . . cord-010119-t1x9gknd 6315 1 Sequencing sequencing NN cord-010119-t1x9gknd 6315 2 showed show VBD cord-010119-t1x9gknd 6315 3 the the DT cord-010119-t1x9gknd 6315 4 c.1154G c.1154g NN cord-010119-t1x9gknd 6315 5 > > XX cord-010119-t1x9gknd 6315 6 C c NN cord-010119-t1x9gknd 6315 7 change change NN cord-010119-t1x9gknd 6315 8 and and CC cord-010119-t1x9gknd 6315 9 the the DT cord-010119-t1x9gknd 6315 10 intronic intronic NNP cord-010119-t1x9gknd 6315 11 c.1154 c.1154 NNP cord-010119-t1x9gknd 6315 12 - - HYPH cord-010119-t1x9gknd 6315 13 8 8 CD cord-010119-t1x9gknd 6315 14 T t NN cord-010119-t1x9gknd 6315 15 > > XX cord-010119-t1x9gknd 6316 1 A a NN cord-010119-t1x9gknd 6316 2 and and CC cord-010119-t1x9gknd 6316 3 c.1154 c.1154 NNP cord-010119-t1x9gknd 6316 4 - - HYPH cord-010119-t1x9gknd 6316 5 31 31 CD cord-010119-t1x9gknd 6316 6 T t NN cord-010119-t1x9gknd 6317 1 > > XX cord-010119-t1x9gknd 6318 1 C C NNP cord-010119-t1x9gknd 6318 2 substitutions substitution NNS cord-010119-t1x9gknd 6318 3 , , , cord-010119-t1x9gknd 6318 4 which which WDT cord-010119-t1x9gknd 6318 5 are be VBP cord-010119-t1x9gknd 6318 6 associated associate VBN cord-010119-t1x9gknd 6318 7 to to IN cord-010119-t1x9gknd 6318 8 the the DT cord-010119-t1x9gknd 6318 9 RHD*weak RHD*weak NNP cord-010119-t1x9gknd 6318 10 D D NNP cord-010119-t1x9gknd 6318 11 type type NN cord-010119-t1x9gknd 6318 12 2 2 CD cord-010119-t1x9gknd 6318 13 allele allele NN cord-010119-t1x9gknd 6318 14 . . . cord-010119-t1x9gknd 6319 1 Conclusion conclusion NN cord-010119-t1x9gknd 6319 2 : : : cord-010119-t1x9gknd 6320 1 Our -PRON- PRP$ cord-010119-t1x9gknd 6320 2 results result NNS cord-010119-t1x9gknd 6320 3 showed show VBD cord-010119-t1x9gknd 6320 4 that that IN cord-010119-t1x9gknd 6320 5 c.1154G c.1154g NN cord-010119-t1x9gknd 6320 6 > > XX cord-010119-t1x9gknd 6320 7 C c NN cord-010119-t1x9gknd 6320 8 associated associate VBN cord-010119-t1x9gknd 6320 9 with with IN cord-010119-t1x9gknd 6320 10 c.1154 c.1154 NNP cord-010119-t1x9gknd 6320 11 - - SYM cord-010119-t1x9gknd 6320 12 8 8 CD cord-010119-t1x9gknd 6320 13 T t NN cord-010119-t1x9gknd 6320 14 > > XX cord-010119-t1x9gknd 6321 1 A a NN cord-010119-t1x9gknd 6321 2 and and CC cord-010119-t1x9gknd 6321 3 c.1154 c.1154 NNP cord-010119-t1x9gknd 6321 4 - - HYPH cord-010119-t1x9gknd 6321 5 31 31 CD cord-010119-t1x9gknd 6321 6 T t NN cord-010119-t1x9gknd 6322 1 > > XX cord-010119-t1x9gknd 6323 1 C c NN cord-010119-t1x9gknd 6323 2 variations variation NNS cord-010119-t1x9gknd 6323 3 had have VBD cord-010119-t1x9gknd 6323 4 probably probably RB cord-010119-t1x9gknd 6323 5 a a DT cord-010119-t1x9gknd 6323 6 functional functional JJ cord-010119-t1x9gknd 6323 7 impact impact NN cord-010119-t1x9gknd 6323 8 on on IN cord-010119-t1x9gknd 6323 9 splicing splice VBG cord-010119-t1x9gknd 6323 10 inducing induce VBG cord-010119-t1x9gknd 6323 11 exclusion exclusion NN cord-010119-t1x9gknd 6323 12 of of IN cord-010119-t1x9gknd 6323 13 exon exon NN cord-010119-t1x9gknd 6323 14 9 9 CD cord-010119-t1x9gknd 6323 15 in in IN cord-010119-t1x9gknd 6323 16 both both DT cord-010119-t1x9gknd 6323 17 DNA DNA NNP cord-010119-t1x9gknd 6323 18 from from IN cord-010119-t1x9gknd 6323 19 mother mother NN cord-010119-t1x9gknd 6323 20 and and CC cord-010119-t1x9gknd 6323 21 newborn newborn JJ cord-010119-t1x9gknd 6323 22 . . . cord-010119-t1x9gknd 6324 1 This this DT cord-010119-t1x9gknd 6324 2 finding finding NN cord-010119-t1x9gknd 6324 3 is be VBZ cord-010119-t1x9gknd 6324 4 important important JJ cord-010119-t1x9gknd 6324 5 to to TO cord-010119-t1x9gknd 6324 6 develop develop VB cord-010119-t1x9gknd 6324 7 assays assay NNS cord-010119-t1x9gknd 6324 8 and and CC cord-010119-t1x9gknd 6324 9 interpret interpret VB cord-010119-t1x9gknd 6324 10 genotyping genotyping NN cord-010119-t1x9gknd 6324 11 results result NNS cord-010119-t1x9gknd 6324 12 , , , cord-010119-t1x9gknd 6324 13 as as IN cord-010119-t1x9gknd 6324 14 current current JJ cord-010119-t1x9gknd 6324 15 guidelines guideline NNS cord-010119-t1x9gknd 6324 16 do do VBP cord-010119-t1x9gknd 6324 17 not not RB cord-010119-t1x9gknd 6324 18 recommend recommend VB cord-010119-t1x9gknd 6324 19 anti anti JJ cord-010119-t1x9gknd 6324 20 - - JJ cord-010119-t1x9gknd 6324 21 D d JJ cord-010119-t1x9gknd 6324 22 IgG igg NN cord-010119-t1x9gknd 6324 23 prophylaxis prophylaxis NN cord-010119-t1x9gknd 6324 24 for for IN cord-010119-t1x9gknd 6324 25 women woman NNS cord-010119-t1x9gknd 6324 26 with with IN cord-010119-t1x9gknd 6324 27 weak weak JJ cord-010119-t1x9gknd 6324 28 D d NN cord-010119-t1x9gknd 6324 29 type type NN cord-010119-t1x9gknd 6324 30 2 2 CD cord-010119-t1x9gknd 6324 31 . . . cord-010119-t1x9gknd 6325 1 Background Background NNP cord-010119-t1x9gknd 6325 2 / / SYM cord-010119-t1x9gknd 6325 3 Case Case NNP cord-010119-t1x9gknd 6325 4 Studies Studies NNPS cord-010119-t1x9gknd 6325 5 : : : cord-010119-t1x9gknd 6325 6 Sickle sickle NN cord-010119-t1x9gknd 6325 7 cell cell NN cord-010119-t1x9gknd 6325 8 disease disease NN cord-010119-t1x9gknd 6325 9 ( ( -LRB- cord-010119-t1x9gknd 6325 10 SCD SCD NNP cord-010119-t1x9gknd 6325 11 ) ) -RRB- cord-010119-t1x9gknd 6325 12 patients patient NNS cord-010119-t1x9gknd 6325 13 require require VBP cord-010119-t1x9gknd 6325 14 red red JJ cord-010119-t1x9gknd 6325 15 blood blood NN cord-010119-t1x9gknd 6325 16 cell cell NN cord-010119-t1x9gknd 6325 17 ( ( -LRB- cord-010119-t1x9gknd 6325 18 RBC RBC NNP cord-010119-t1x9gknd 6325 19 ) ) -RRB- cord-010119-t1x9gknd 6325 20 transfusions transfusion NNS cord-010119-t1x9gknd 6325 21 to to TO cord-010119-t1x9gknd 6325 22 minimize minimize VB cord-010119-t1x9gknd 6325 23 disease disease NN cord-010119-t1x9gknd 6325 24 - - HYPH cord-010119-t1x9gknd 6325 25 specific specific JJ cord-010119-t1x9gknd 6325 26 symptomatology symptomatology NN cord-010119-t1x9gknd 6325 27 . . . cord-010119-t1x9gknd 6326 1 Previous previous JJ cord-010119-t1x9gknd 6326 2 studies study NNS cord-010119-t1x9gknd 6326 3 have have VBP cord-010119-t1x9gknd 6326 4 shown show VBN cord-010119-t1x9gknd 6326 5 that that IN cord-010119-t1x9gknd 6326 6 more more JJR cord-010119-t1x9gknd 6326 7 than than IN cord-010119-t1x9gknd 6326 8 50 50 CD cord-010119-t1x9gknd 6326 9 % % NN cord-010119-t1x9gknd 6326 10 of of IN cord-010119-t1x9gknd 6326 11 children child NNS cord-010119-t1x9gknd 6326 12 with with IN cord-010119-t1x9gknd 6326 13 SCD SCD NNP cord-010119-t1x9gknd 6326 14 receive receive VBP cord-010119-t1x9gknd 6326 15 at at IN cord-010119-t1x9gknd 6326 16 least least RBS cord-010119-t1x9gknd 6326 17 one one CD cord-010119-t1x9gknd 6326 18 RBC RBC NNP cord-010119-t1x9gknd 6326 19 transfusion transfusion NN cord-010119-t1x9gknd 6326 20 in in IN cord-010119-t1x9gknd 6326 21 their -PRON- PRP$ cord-010119-t1x9gknd 6326 22 lifetime lifetime NN cord-010119-t1x9gknd 6326 23 . . . cord-010119-t1x9gknd 6327 1 Both both DT cord-010119-t1x9gknd 6327 2 simple simple JJ cord-010119-t1x9gknd 6327 3 transfusions transfusion NNS cord-010119-t1x9gknd 6327 4 and and CC cord-010119-t1x9gknd 6327 5 erythrocytapheresis erythrocytapheresis NN cord-010119-t1x9gknd 6327 6 are be VBP cord-010119-t1x9gknd 6327 7 associated associate VBN cord-010119-t1x9gknd 6327 8 with with IN cord-010119-t1x9gknd 6327 9 increased increase VBN cord-010119-t1x9gknd 6327 10 risk risk NN cord-010119-t1x9gknd 6327 11 of of IN cord-010119-t1x9gknd 6327 12 RBC RBC NNP cord-010119-t1x9gknd 6327 13 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6327 14 . . . cord-010119-t1x9gknd 6328 1 Published publish VBN cord-010119-t1x9gknd 6328 2 literature literature NN cord-010119-t1x9gknd 6328 3 is be VBZ cord-010119-t1x9gknd 6328 4 lacking lack VBG cord-010119-t1x9gknd 6328 5 on on IN cord-010119-t1x9gknd 6328 6 the the DT cord-010119-t1x9gknd 6328 7 frequency frequency NN cord-010119-t1x9gknd 6328 8 of of IN cord-010119-t1x9gknd 6328 9 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6328 10 and and CC cord-010119-t1x9gknd 6328 11 geographical geographical JJ cord-010119-t1x9gknd 6328 12 associations association NNS cord-010119-t1x9gknd 6328 13 in in IN cord-010119-t1x9gknd 6328 14 pediatric pediatric JJ cord-010119-t1x9gknd 6328 15 populations population NNS cord-010119-t1x9gknd 6328 16 , , , cord-010119-t1x9gknd 6328 17 which which WDT cord-010119-t1x9gknd 6328 18 is be VBZ cord-010119-t1x9gknd 6328 19 made make VBN cord-010119-t1x9gknd 6328 20 difficult difficult JJ cord-010119-t1x9gknd 6328 21 to to TO cord-010119-t1x9gknd 6328 22 compare compare VB cord-010119-t1x9gknd 6328 23 due due IN cord-010119-t1x9gknd 6328 24 to to IN cord-010119-t1x9gknd 6328 25 lack lack NN cord-010119-t1x9gknd 6328 26 of of IN cord-010119-t1x9gknd 6328 27 standardized standardized JJ cord-010119-t1x9gknd 6328 28 categorization categorization NN cord-010119-t1x9gknd 6328 29 of of IN cord-010119-t1x9gknd 6328 30 what what WP cord-010119-t1x9gknd 6328 31 represents represent VBZ cord-010119-t1x9gknd 6328 32 a a DT cord-010119-t1x9gknd 6328 33 pediatric pediatric JJ cord-010119-t1x9gknd 6328 34 patient patient JJ cord-010119-t1x9gknd 6328 35 population population NN cord-010119-t1x9gknd 6328 36 across across IN cord-010119-t1x9gknd 6328 37 studies study NNS cord-010119-t1x9gknd 6328 38 . . . cord-010119-t1x9gknd 6329 1 Therefore therefore RB cord-010119-t1x9gknd 6329 2 , , , cord-010119-t1x9gknd 6329 3 we -PRON- PRP cord-010119-t1x9gknd 6329 4 looked look VBD cord-010119-t1x9gknd 6329 5 at at IN cord-010119-t1x9gknd 6329 6 the the DT cord-010119-t1x9gknd 6329 7 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6329 8 rates rate NNS cord-010119-t1x9gknd 6329 9 of of IN cord-010119-t1x9gknd 6329 10 pediatric pediatric JJ cord-010119-t1x9gknd 6329 11 patients patient NNS cord-010119-t1x9gknd 6329 12 with with IN cord-010119-t1x9gknd 6329 13 SCD SCD NNP cord-010119-t1x9gknd 6329 14 in in IN cord-010119-t1x9gknd 6329 15 the the DT cord-010119-t1x9gknd 6329 16 Unites Unites NNPS cord-010119-t1x9gknd 6329 17 States States NNP cord-010119-t1x9gknd 6329 18 ( ( -LRB- cord-010119-t1x9gknd 6329 19 US US NNP cord-010119-t1x9gknd 6329 20 ) ) -RRB- cord-010119-t1x9gknd 6329 21 and and CC cord-010119-t1x9gknd 6329 22 other other JJ cord-010119-t1x9gknd 6329 23 countries country NNS cord-010119-t1x9gknd 6329 24 . . . cord-010119-t1x9gknd 6330 1 Study Study NNP cord-010119-t1x9gknd 6330 2 Design Design NNP cord-010119-t1x9gknd 6330 3 / / SYM cord-010119-t1x9gknd 6330 4 Method method NN cord-010119-t1x9gknd 6330 5 : : : cord-010119-t1x9gknd 6331 1 A a DT cord-010119-t1x9gknd 6331 2 literature literature NN cord-010119-t1x9gknd 6331 3 search search NN cord-010119-t1x9gknd 6331 4 was be VBD cord-010119-t1x9gknd 6331 5 performed perform VBN cord-010119-t1x9gknd 6331 6 for for IN cord-010119-t1x9gknd 6331 7 studies study NNS cord-010119-t1x9gknd 6331 8 published publish VBN cord-010119-t1x9gknd 6331 9 on on IN cord-010119-t1x9gknd 6331 10 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6331 11 rates rate NNS cord-010119-t1x9gknd 6331 12 of of IN cord-010119-t1x9gknd 6331 13 SCD SCD NNP cord-010119-t1x9gknd 6331 14 pediatric pediatric JJ cord-010119-t1x9gknd 6331 15 patients patient NNS cord-010119-t1x9gknd 6331 16 including include VBG cord-010119-t1x9gknd 6331 17 HbSS HbSS NNP cord-010119-t1x9gknd 6331 18 , , , cord-010119-t1x9gknd 6331 19 sickle sickle NN cord-010119-t1x9gknd 6331 20 beta beta NN cord-010119-t1x9gknd 6331 21 - - HYPH cord-010119-t1x9gknd 6331 22 thalassemia thalassemia NN cord-010119-t1x9gknd 6331 23 and and CC cord-010119-t1x9gknd 6331 24 HbSC HbSC NNS cord-010119-t1x9gknd 6331 25 . . . cord-010119-t1x9gknd 6332 1 We -PRON- PRP cord-010119-t1x9gknd 6332 2 evaluated evaluate VBD cord-010119-t1x9gknd 6332 3 the the DT cord-010119-t1x9gknd 6332 4 overall overall JJ cord-010119-t1x9gknd 6332 5 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6332 6 rates rate NNS cord-010119-t1x9gknd 6332 7 as as IN cord-010119-t1x9gknd 6332 8 number number NN cord-010119-t1x9gknd 6332 9 of of IN cord-010119-t1x9gknd 6332 10 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6332 11 per per IN cord-010119-t1x9gknd 6332 12 transfused transfuse VBN cord-010119-t1x9gknd 6332 13 patient patient NN cord-010119-t1x9gknd 6332 14 and and CC cord-010119-t1x9gknd 6332 15 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6332 16 per per IN cord-010119-t1x9gknd 6332 17 100 100 CD cord-010119-t1x9gknd 6332 18 transfused transfused JJ cord-010119-t1x9gknd 6332 19 units unit NNS cord-010119-t1x9gknd 6332 20 across across IN cord-010119-t1x9gknd 6332 21 world world NN cord-010119-t1x9gknd 6332 22 literature literature NN cord-010119-t1x9gknd 6332 23 and and CC cord-010119-t1x9gknd 6332 24 compared compare VBD cord-010119-t1x9gknd 6332 25 them -PRON- PRP cord-010119-t1x9gknd 6332 26 using use VBG cord-010119-t1x9gknd 6332 27 chi chi JJ cord-010119-t1x9gknd 6332 28 - - HYPH cord-010119-t1x9gknd 6332 29 square square JJ cord-010119-t1x9gknd 6332 30 analysis analysis NN cord-010119-t1x9gknd 6332 31 . . . cord-010119-t1x9gknd 6333 1 Results result NNS cord-010119-t1x9gknd 6333 2 / / SYM cord-010119-t1x9gknd 6333 3 Finding finding NN cord-010119-t1x9gknd 6333 4 : : : cord-010119-t1x9gknd 6334 1 Fourteen fourteen CD cord-010119-t1x9gknd 6334 2 studies study NNS cord-010119-t1x9gknd 6334 3 reporting report VBG cord-010119-t1x9gknd 6334 4 data datum NNS cord-010119-t1x9gknd 6334 5 to to TO cord-010119-t1x9gknd 6334 6 derive derive VB cord-010119-t1x9gknd 6334 7 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6334 8 rates rate NNS cord-010119-t1x9gknd 6334 9 of of IN cord-010119-t1x9gknd 6334 10 pediatric pediatric JJ cord-010119-t1x9gknd 6334 11 SCD SCD NNP cord-010119-t1x9gknd 6334 12 patients patient NNS cord-010119-t1x9gknd 6334 13 were be VBD cord-010119-t1x9gknd 6334 14 found find VBN cord-010119-t1x9gknd 6334 15 . . . cord-010119-t1x9gknd 6335 1 These these DT cord-010119-t1x9gknd 6335 2 included include VBD cord-010119-t1x9gknd 6335 3 eleven eleven CD cord-010119-t1x9gknd 6335 4 US US NNP cord-010119-t1x9gknd 6335 5 studies study NNS cord-010119-t1x9gknd 6335 6 with with IN cord-010119-t1x9gknd 6335 7 1,057 1,057 CD cord-010119-t1x9gknd 6335 8 patients patient NNS cord-010119-t1x9gknd 6335 9 and and CC cord-010119-t1x9gknd 6335 10 3 3 CD cord-010119-t1x9gknd 6335 11 studies study NNS cord-010119-t1x9gknd 6335 12 from from IN cord-010119-t1x9gknd 6335 13 other other JJ cord-010119-t1x9gknd 6335 14 regions region NNS cord-010119-t1x9gknd 6335 15 ( ( -LRB- cord-010119-t1x9gknd 6335 16 Brazil Brazil NNP cord-010119-t1x9gknd 6335 17 , , , cord-010119-t1x9gknd 6335 18 Egypt Egypt NNP cord-010119-t1x9gknd 6335 19 and and CC cord-010119-t1x9gknd 6335 20 France France NNP cord-010119-t1x9gknd 6335 21 ) ) -RRB- cord-010119-t1x9gknd 6335 22 with with IN cord-010119-t1x9gknd 6335 23 641 641 CD cord-010119-t1x9gknd 6335 24 patients patient NNS cord-010119-t1x9gknd 6335 25 . . . cord-010119-t1x9gknd 6336 1 Majority majority NN cord-010119-t1x9gknd 6336 2 of of IN cord-010119-t1x9gknd 6336 3 patients patient NNS cord-010119-t1x9gknd 6336 4 included include VBN cord-010119-t1x9gknd 6336 5 in in IN cord-010119-t1x9gknd 6336 6 the the DT cord-010119-t1x9gknd 6336 7 studies study NNS cord-010119-t1x9gknd 6336 8 had have VBD cord-010119-t1x9gknd 6336 9 HbSS HbSS NNP cord-010119-t1x9gknd 6336 10 disease disease NN cord-010119-t1x9gknd 6336 11 . . . cord-010119-t1x9gknd 6337 1 Patients patient NNS cord-010119-t1x9gknd 6337 2 received receive VBD cord-010119-t1x9gknd 6337 3 either either CC cord-010119-t1x9gknd 6337 4 episodic episodic JJ cord-010119-t1x9gknd 6337 5 , , , cord-010119-t1x9gknd 6337 6 chronic chronic JJ cord-010119-t1x9gknd 6337 7 simple simple JJ cord-010119-t1x9gknd 6337 8 transfusions transfusion NNS cord-010119-t1x9gknd 6337 9 or or CC cord-010119-t1x9gknd 6337 10 erythrocytapheresis erythrocytapheresis NN cord-010119-t1x9gknd 6337 11 . . . cord-010119-t1x9gknd 6338 1 Age age NN cord-010119-t1x9gknd 6338 2 range range NN cord-010119-t1x9gknd 6338 3 for for IN cord-010119-t1x9gknd 6338 4 the the DT cord-010119-t1x9gknd 6338 5 US US NNP cord-010119-t1x9gknd 6338 6 studies study NNS cord-010119-t1x9gknd 6338 7 was be VBD cord-010119-t1x9gknd 6338 8 0 0 CD cord-010119-t1x9gknd 6338 9 to to IN cord-010119-t1x9gknd 6338 10 26 26 CD cord-010119-t1x9gknd 6338 11 years year NNS cord-010119-t1x9gknd 6338 12 and and CC cord-010119-t1x9gknd 6338 13 for for IN cord-010119-t1x9gknd 6338 14 the the DT cord-010119-t1x9gknd 6338 15 other other JJ cord-010119-t1x9gknd 6338 16 countries country NNS cord-010119-t1x9gknd 6338 17 0 0 CD cord-010119-t1x9gknd 6338 18 to to IN cord-010119-t1x9gknd 6338 19 20 20 CD cord-010119-t1x9gknd 6338 20 years year NNS cord-010119-t1x9gknd 6338 21 . . . cord-010119-t1x9gknd 6339 1 Available available JJ cord-010119-t1x9gknd 6339 2 data datum NNS cord-010119-t1x9gknd 6339 3 from from IN cord-010119-t1x9gknd 6339 4 5 5 CD cord-010119-t1x9gknd 6339 5 US US NNP cord-010119-t1x9gknd 6339 6 studies study NNS cord-010119-t1x9gknd 6339 7 included include VBD cord-010119-t1x9gknd 6339 8 a a DT cord-010119-t1x9gknd 6339 9 total total NN cord-010119-t1x9gknd 6339 10 of of IN cord-010119-t1x9gknd 6339 11 91 91 CD cord-010119-t1x9gknd 6339 12 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6339 13 , , , cord-010119-t1x9gknd 6339 14 the the DT cord-010119-t1x9gknd 6339 15 most most RBS cord-010119-t1x9gknd 6339 16 frequent frequent JJ cord-010119-t1x9gknd 6339 17 of of IN cord-010119-t1x9gknd 6339 18 which which WDT cord-010119-t1x9gknd 6339 19 were be VBD cord-010119-t1x9gknd 6339 20 antibodies antibody NNS cord-010119-t1x9gknd 6339 21 to to IN cord-010119-t1x9gknd 6339 22 C C NNP cord-010119-t1x9gknd 6339 23 , , , cord-010119-t1x9gknd 6339 24 E E NNP cord-010119-t1x9gknd 6339 25 , , , cord-010119-t1x9gknd 6339 26 Kell Kell NNP cord-010119-t1x9gknd 6339 27 , , , cord-010119-t1x9gknd 6339 28 M M NNP cord-010119-t1x9gknd 6339 29 , , , cord-010119-t1x9gknd 6339 30 S S NNP cord-010119-t1x9gknd 6339 31 and and CC cord-010119-t1x9gknd 6339 32 Kidd Kidd NNP cord-010119-t1x9gknd 6339 33 antigens antigen NNS cord-010119-t1x9gknd 6339 34 ( ( -LRB- cord-010119-t1x9gknd 6339 35 18.7 18.7 CD cord-010119-t1x9gknd 6339 36 % % NN cord-010119-t1x9gknd 6339 37 , , , cord-010119-t1x9gknd 6339 38 16.5 16.5 CD cord-010119-t1x9gknd 6339 39 % % NN cord-010119-t1x9gknd 6339 40 , , , cord-010119-t1x9gknd 6339 41 15.4 15.4 CD cord-010119-t1x9gknd 6339 42 % % NN cord-010119-t1x9gknd 6339 43 , , , cord-010119-t1x9gknd 6339 44 7.7 7.7 CD cord-010119-t1x9gknd 6339 45 % % NN cord-010119-t1x9gknd 6339 46 , , , cord-010119-t1x9gknd 6339 47 7.7 7.7 CD cord-010119-t1x9gknd 6339 48 % % NN cord-010119-t1x9gknd 6339 49 and and CC cord-010119-t1x9gknd 6339 50 6.5 6.5 CD cord-010119-t1x9gknd 6339 51 % % NN cord-010119-t1x9gknd 6339 52 respectively respectively RB cord-010119-t1x9gknd 6339 53 ) ) -RRB- cord-010119-t1x9gknd 6339 54 . . . cord-010119-t1x9gknd 6340 1 Alloimmunization alloimmunization NN cord-010119-t1x9gknd 6340 2 rates rate NNS cord-010119-t1x9gknd 6340 3 were be VBD cord-010119-t1x9gknd 6340 4 calculated calculate VBN cord-010119-t1x9gknd 6340 5 as as IN cord-010119-t1x9gknd 6340 6 antibodies antibody NNS cord-010119-t1x9gknd 6340 7 per per IN cord-010119-t1x9gknd 6340 8 patient patient NN cord-010119-t1x9gknd 6340 9 in in IN cord-010119-t1x9gknd 6340 10 some some DT cord-010119-t1x9gknd 6340 11 studies study NNS cord-010119-t1x9gknd 6340 12 and and CC cord-010119-t1x9gknd 6340 13 antibodies antibody NNS cord-010119-t1x9gknd 6340 14 per per IN cord-010119-t1x9gknd 6340 15 100 100 CD cord-010119-t1x9gknd 6340 16 transfused transfused JJ cord-010119-t1x9gknd 6340 17 units unit NNS cord-010119-t1x9gknd 6340 18 in in IN cord-010119-t1x9gknd 6340 19 other other JJ cord-010119-t1x9gknd 6340 20 studies study NNS cord-010119-t1x9gknd 6340 21 . . . cord-010119-t1x9gknd 6341 1 We -PRON- PRP cord-010119-t1x9gknd 6341 2 evaluated evaluate VBD cord-010119-t1x9gknd 6341 3 rates rate NNS cord-010119-t1x9gknd 6341 4 using use VBG cord-010119-t1x9gknd 6341 5 both both DT cord-010119-t1x9gknd 6341 6 approaches approach NNS cord-010119-t1x9gknd 6341 7 as as IN cord-010119-t1x9gknd 6341 8 per per IN cord-010119-t1x9gknd 6341 9 available available JJ cord-010119-t1x9gknd 6341 10 data datum NNS cord-010119-t1x9gknd 6341 11 . . . cord-010119-t1x9gknd 6342 1 US US NNP cord-010119-t1x9gknd 6342 2 had have VBD cord-010119-t1x9gknd 6342 3 an an DT cord-010119-t1x9gknd 6342 4 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6342 5 rate rate NN cord-010119-t1x9gknd 6342 6 of of IN cord-010119-t1x9gknd 6342 7 16.5 16.5 CD cord-010119-t1x9gknd 6342 8 % % NN cord-010119-t1x9gknd 6342 9 ( ( -LRB- cord-010119-t1x9gknd 6342 10 14.1 14.1 CD cord-010119-t1x9gknd 6342 11 to to IN cord-010119-t1x9gknd 6342 12 19.2 19.2 CD cord-010119-t1x9gknd 6342 13 , , , cord-010119-t1x9gknd 6342 14 95 95 CD cord-010119-t1x9gknd 6342 15 % % NN cord-010119-t1x9gknd 6342 16 CI CI NNP cord-010119-t1x9gknd 6342 17 ) ) -RRB- cord-010119-t1x9gknd 6342 18 vs. vs. IN cord-010119-t1x9gknd 6342 19 9.4 9.4 CD cord-010119-t1x9gknd 6342 20 % % NN cord-010119-t1x9gknd 6342 21 for for IN cord-010119-t1x9gknd 6342 22 non non JJ cord-010119-t1x9gknd 6342 23 - - JJ cord-010119-t1x9gknd 6342 24 US US NNP cord-010119-t1x9gknd 6342 25 studies study NNS cord-010119-t1x9gknd 6342 26 ( ( -LRB- cord-010119-t1x9gknd 6342 27 7.3 7.3 CD cord-010119-t1x9gknd 6342 28 - - SYM cord-010119-t1x9gknd 6342 29 11.8 11.8 CD cord-010119-t1x9gknd 6342 30 , , , cord-010119-t1x9gknd 6342 31 95 95 CD cord-010119-t1x9gknd 6342 32 % % NN cord-010119-t1x9gknd 6342 33 CI ci NN cord-010119-t1x9gknd 6342 34 ) ) -RRB- cord-010119-t1x9gknd 6342 35 ( ( -LRB- cord-010119-t1x9gknd 6342 36 p50.0008 p50.0008 NNP cord-010119-t1x9gknd 6342 37 ) ) -RRB- cord-010119-t1x9gknd 6342 38 and and CC cord-010119-t1x9gknd 6342 39 134A 134a CD cord-010119-t1x9gknd 6342 40 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 6342 41 2017 2017 CD cord-010119-t1x9gknd 6342 42 Vol Vol NNP cord-010119-t1x9gknd 6342 43 . . . cord-010119-t1x9gknd 6343 1 57 57 CD cord-010119-t1x9gknd 6343 2 Supplement supplement NN cord-010119-t1x9gknd 6343 3 S3 S3 NNP cord-010119-t1x9gknd 6343 4 more more JJR cord-010119-t1x9gknd 6343 5 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6343 6 per per IN cord-010119-t1x9gknd 6343 7 transfused transfuse VBN cord-010119-t1x9gknd 6343 8 patient patient NN cord-010119-t1x9gknd 6343 9 ( ( -LRB- cord-010119-t1x9gknd 6343 10 0.25 0.25 CD cord-010119-t1x9gknd 6343 11 vs. vs. IN cord-010119-t1x9gknd 6343 12 0.096 0.096 CD cord-010119-t1x9gknd 6343 13 , , , cord-010119-t1x9gknd 6343 14 p50.0001 p50.0001 NNP cord-010119-t1x9gknd 6343 15 ) ) -RRB- cord-010119-t1x9gknd 6343 16 . . . cord-010119-t1x9gknd 6344 1 Similarly similarly RB cord-010119-t1x9gknd 6344 2 , , , cord-010119-t1x9gknd 6344 3 the the DT cord-010119-t1x9gknd 6344 4 number number NN cord-010119-t1x9gknd 6344 5 of of IN cord-010119-t1x9gknd 6344 6 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6344 7 per per IN cord-010119-t1x9gknd 6344 8 100 100 CD cord-010119-t1x9gknd 6344 9 transfused transfused JJ cord-010119-t1x9gknd 6344 10 units unit NNS cord-010119-t1x9gknd 6344 11 in in IN cord-010119-t1x9gknd 6344 12 the the DT cord-010119-t1x9gknd 6344 13 US US NNP cord-010119-t1x9gknd 6344 14 , , , cord-010119-t1x9gknd 6344 15 evaluated evaluate VBN cord-010119-t1x9gknd 6344 16 from from IN cord-010119-t1x9gknd 6344 17 five five CD cord-010119-t1x9gknd 6344 18 studies study NNS cord-010119-t1x9gknd 6344 19 , , , cord-010119-t1x9gknd 6344 20 was be VBD cord-010119-t1x9gknd 6344 21 higher high JJR cord-010119-t1x9gknd 6344 22 compared compare VBN cord-010119-t1x9gknd 6344 23 to to IN cord-010119-t1x9gknd 6344 24 a a DT cord-010119-t1x9gknd 6344 25 large large JJ cord-010119-t1x9gknd 6344 26 French french JJ cord-010119-t1x9gknd 6344 27 patient patient NN cord-010119-t1x9gknd 6344 28 cohort cohort NN cord-010119-t1x9gknd 6344 29 ( ( -LRB- cord-010119-t1x9gknd 6344 30 0Á68 0á68 CD cord-010119-t1x9gknd 6344 31 vs. vs. IN cord-010119-t1x9gknd 6344 32 0.33 0.33 CD cord-010119-t1x9gknd 6344 33 , , , cord-010119-t1x9gknd 6344 34 p50Á0005 p50á0005 CD cord-010119-t1x9gknd 6344 35 ) ) -RRB- cord-010119-t1x9gknd 6344 36 . . . cord-010119-t1x9gknd 6345 1 Average average JJ cord-010119-t1x9gknd 6345 2 number number NN cord-010119-t1x9gknd 6345 3 of of IN cord-010119-t1x9gknd 6345 4 RBC RBC NNP cord-010119-t1x9gknd 6345 5 units unit NNS cord-010119-t1x9gknd 6345 6 transfused transfuse VBN cord-010119-t1x9gknd 6345 7 per per IN cord-010119-t1x9gknd 6345 8 patient patient NN cord-010119-t1x9gknd 6345 9 in in IN cord-010119-t1x9gknd 6345 10 the the DT cord-010119-t1x9gknd 6345 11 US US NNP cord-010119-t1x9gknd 6345 12 was be VBD cord-010119-t1x9gknd 6345 13 also also RB cord-010119-t1x9gknd 6345 14 higher high JJR cord-010119-t1x9gknd 6345 15 compared compare VBN cord-010119-t1x9gknd 6345 16 to to IN cord-010119-t1x9gknd 6345 17 data datum NNS cord-010119-t1x9gknd 6345 18 from from IN cord-010119-t1x9gknd 6345 19 France France NNP cord-010119-t1x9gknd 6345 20 ( ( -LRB- cord-010119-t1x9gknd 6345 21 77 77 CD cord-010119-t1x9gknd 6345 22 vs. vs. IN cord-010119-t1x9gknd 6345 23 45 45 CD cord-010119-t1x9gknd 6345 24 , , , cord-010119-t1x9gknd 6345 25 p50.0001 p50.0001 NNP cord-010119-t1x9gknd 6345 26 ) ) -RRB- cord-010119-t1x9gknd 6345 27 . . . cord-010119-t1x9gknd 6346 1 Conclusion conclusion NN cord-010119-t1x9gknd 6346 2 : : : cord-010119-t1x9gknd 6347 1 Despite despite IN cord-010119-t1x9gknd 6347 2 limited limited JJ cord-010119-t1x9gknd 6347 3 studies study NNS cord-010119-t1x9gknd 6347 4 available available JJ cord-010119-t1x9gknd 6347 5 to to TO cord-010119-t1x9gknd 6347 6 compare compare VB cord-010119-t1x9gknd 6347 7 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6347 8 rates rate NNS cord-010119-t1x9gknd 6347 9 in in IN cord-010119-t1x9gknd 6347 10 pediatric pediatric JJ cord-010119-t1x9gknd 6347 11 SCD SCD NNP cord-010119-t1x9gknd 6347 12 patients patient NNS cord-010119-t1x9gknd 6347 13 in in IN cord-010119-t1x9gknd 6347 14 the the DT cord-010119-t1x9gknd 6347 15 US US NNP cord-010119-t1x9gknd 6347 16 and and CC cord-010119-t1x9gknd 6347 17 other other JJ cord-010119-t1x9gknd 6347 18 countries country NNS cord-010119-t1x9gknd 6347 19 , , , cord-010119-t1x9gknd 6347 20 the the DT cord-010119-t1x9gknd 6347 21 overall overall JJ cord-010119-t1x9gknd 6347 22 rates rate NNS cord-010119-t1x9gknd 6347 23 are be VBP cord-010119-t1x9gknd 6347 24 higher high JJR cord-010119-t1x9gknd 6347 25 in in IN cord-010119-t1x9gknd 6347 26 the the DT cord-010119-t1x9gknd 6347 27 US US NNP cord-010119-t1x9gknd 6347 28 . . . cord-010119-t1x9gknd 6348 1 Though though IN cord-010119-t1x9gknd 6348 2 no no DT cord-010119-t1x9gknd 6348 3 definitive definitive JJ cord-010119-t1x9gknd 6348 4 reasons reason NNS cord-010119-t1x9gknd 6348 5 could could MD cord-010119-t1x9gknd 6348 6 be be VB cord-010119-t1x9gknd 6348 7 concluded conclude VBN cord-010119-t1x9gknd 6348 8 from from IN cord-010119-t1x9gknd 6348 9 the the DT cord-010119-t1x9gknd 6348 10 available available JJ cord-010119-t1x9gknd 6348 11 data datum NNS cord-010119-t1x9gknd 6348 12 , , , cord-010119-t1x9gknd 6348 13 limiting limit VBG cord-010119-t1x9gknd 6348 14 the the DT cord-010119-t1x9gknd 6348 15 number number NN cord-010119-t1x9gknd 6348 16 of of IN cord-010119-t1x9gknd 6348 17 RBC RBC NNP cord-010119-t1x9gknd 6348 18 exposures exposure NNS cord-010119-t1x9gknd 6348 19 , , , cord-010119-t1x9gknd 6348 20 i.e. i.e. FW cord-010119-t1x9gknd 6348 21 units unit NNS cord-010119-t1x9gknd 6348 22 transfused transfuse VBN cord-010119-t1x9gknd 6348 23 in in IN cord-010119-t1x9gknd 6348 24 non non JJ cord-010119-t1x9gknd 6348 25 - - JJ cord-010119-t1x9gknd 6348 26 critical critical JJ cord-010119-t1x9gknd 6348 27 conditions condition NNS cord-010119-t1x9gknd 6348 28 could could MD cord-010119-t1x9gknd 6348 29 lead lead VB cord-010119-t1x9gknd 6348 30 to to IN cord-010119-t1x9gknd 6348 31 lower lower VB cord-010119-t1x9gknd 6348 32 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6348 33 rates rate NNS cord-010119-t1x9gknd 6348 34 . . . cord-010119-t1x9gknd 6349 1 Results result NNS cord-010119-t1x9gknd 6349 2 / / SYM cord-010119-t1x9gknd 6349 3 Findings finding NNS cord-010119-t1x9gknd 6349 4 : : : cord-010119-t1x9gknd 6350 1 A a DT cord-010119-t1x9gknd 6350 2 post post JJ cord-010119-t1x9gknd 6350 3 - - JJ cord-010119-t1x9gknd 6350 4 transfusion transfusion JJ cord-010119-t1x9gknd 6350 5 sample sample NN cord-010119-t1x9gknd 6350 6 was be VBD cord-010119-t1x9gknd 6350 7 referred refer VBN cord-010119-t1x9gknd 6350 8 to to IN cord-010119-t1x9gknd 6350 9 the the DT cord-010119-t1x9gknd 6350 10 IRL IRL NNP cord-010119-t1x9gknd 6350 11 for for IN cord-010119-t1x9gknd 6350 12 a a DT cord-010119-t1x9gknd 6350 13 TRXN TRXN NNP cord-010119-t1x9gknd 6350 14 investigation investigation NN cord-010119-t1x9gknd 6350 15 . . . cord-010119-t1x9gknd 6351 1 There there EX cord-010119-t1x9gknd 6351 2 were be VBD cord-010119-t1x9gknd 6351 3 no no DT cord-010119-t1x9gknd 6351 4 clerical clerical JJ cord-010119-t1x9gknd 6351 5 errors error NNS cord-010119-t1x9gknd 6351 6 ; ; : cord-010119-t1x9gknd 6351 7 however however RB cord-010119-t1x9gknd 6351 8 , , , cord-010119-t1x9gknd 6351 9 hemolysis hemolysis NN cord-010119-t1x9gknd 6351 10 was be VBD cord-010119-t1x9gknd 6351 11 present present JJ cord-010119-t1x9gknd 6351 12 in in IN cord-010119-t1x9gknd 6351 13 the the DT cord-010119-t1x9gknd 6351 14 post post JJ cord-010119-t1x9gknd 6351 15 - - JJ cord-010119-t1x9gknd 6351 16 transfusion transfusion NN cord-010119-t1x9gknd 6351 17 plasma plasma NN cord-010119-t1x9gknd 6351 18 / / SYM cord-010119-t1x9gknd 6351 19 serum serum NN cord-010119-t1x9gknd 6351 20 . . . cord-010119-t1x9gknd 6352 1 ABO ABO NNP cord-010119-t1x9gknd 6352 2 / / SYM cord-010119-t1x9gknd 6352 3 Rh Rh NNP cord-010119-t1x9gknd 6352 4 and and CC cord-010119-t1x9gknd 6352 5 crossmatches crossmatche VBZ cord-010119-t1x9gknd 6352 6 using use VBG cord-010119-t1x9gknd 6352 7 LO LO NNP cord-010119-t1x9gknd 6352 8 - - HYPH cord-010119-t1x9gknd 6352 9 ION ION NNP cord-010119-t1x9gknd 6352 10 TM TM NNP cord-010119-t1x9gknd 6352 11 were be VBD cord-010119-t1x9gknd 6352 12 repeated repeat VBN cord-010119-t1x9gknd 6352 13 on on IN cord-010119-t1x9gknd 6352 14 the the DT cord-010119-t1x9gknd 6352 15 pre pre NN cord-010119-t1x9gknd 6352 16 - - JJ cord-010119-t1x9gknd 6352 17 and and CC cord-010119-t1x9gknd 6352 18 post post JJ cord-010119-t1x9gknd 6352 19 - - JJ cord-010119-t1x9gknd 6352 20 transfusion transfusion NN cord-010119-t1x9gknd 6352 21 samples sample NNS cord-010119-t1x9gknd 6352 22 with with IN cord-010119-t1x9gknd 6352 23 no no DT cord-010119-t1x9gknd 6352 24 discrepancies discrepancy NNS cord-010119-t1x9gknd 6352 25 . . . cord-010119-t1x9gknd 6353 1 The the DT cord-010119-t1x9gknd 6353 2 post post JJ cord-010119-t1x9gknd 6353 3 - - JJ cord-010119-t1x9gknd 6353 4 transfusion transfusion NN cord-010119-t1x9gknd 6353 5 DAT DAT NNP cord-010119-t1x9gknd 6353 6 was be VBD cord-010119-t1x9gknd 6353 7 positive positive JJ cord-010119-t1x9gknd 6353 8 with with IN cord-010119-t1x9gknd 6353 9 a a DT cord-010119-t1x9gknd 6353 10 negative negative JJ cord-010119-t1x9gknd 6353 11 eluate eluate NN cord-010119-t1x9gknd 6353 12 . . . cord-010119-t1x9gknd 6354 1 The the DT cord-010119-t1x9gknd 6354 2 hospital hospital NN cord-010119-t1x9gknd 6354 3 requested request VBD cord-010119-t1x9gknd 6354 4 another another DT cord-010119-t1x9gknd 6354 5 unit unit NN cord-010119-t1x9gknd 6354 6 before before IN cord-010119-t1x9gknd 6354 7 the the DT cord-010119-t1x9gknd 6354 8 investigation investigation NN cord-010119-t1x9gknd 6354 9 was be VBD cord-010119-t1x9gknd 6354 10 complete complete JJ cord-010119-t1x9gknd 6354 11 . . . cord-010119-t1x9gknd 6355 1 Antibody antibody NN cord-010119-t1x9gknd 6355 2 identification identification NN cord-010119-t1x9gknd 6355 3 on on IN cord-010119-t1x9gknd 6355 4 the the DT cord-010119-t1x9gknd 6355 5 post post JJ cord-010119-t1x9gknd 6355 6 transfusion transfusion NN cord-010119-t1x9gknd 6355 7 sample sample NN cord-010119-t1x9gknd 6355 8 with with IN cord-010119-t1x9gknd 6355 9 LO LO NNP cord-010119-t1x9gknd 6355 10 - - HYPH cord-010119-t1x9gknd 6355 11 ION ION NNP cord-010119-t1x9gknd 6355 12 TM TM NNP cord-010119-t1x9gknd 6355 13 was be VBD cord-010119-t1x9gknd 6355 14 negative negative JJ cord-010119-t1x9gknd 6355 15 . . . cord-010119-t1x9gknd 6356 1 Suspecting suspect VBG cord-010119-t1x9gknd 6356 2 a a DT cord-010119-t1x9gknd 6356 3 weak weak JJ cord-010119-t1x9gknd 6356 4 antibody antibody NN cord-010119-t1x9gknd 6356 5 , , , cord-010119-t1x9gknd 6356 6 additional additional JJ cord-010119-t1x9gknd 6356 7 investigation investigation NN cord-010119-t1x9gknd 6356 8 using use VBG cord-010119-t1x9gknd 6356 9 PeG peg JJ cord-010119-t1x9gknd 6356 10 TM TM NNP cord-010119-t1x9gknd 6356 11 on on IN cord-010119-t1x9gknd 6356 12 both both DT cord-010119-t1x9gknd 6356 13 samples sample NNS cord-010119-t1x9gknd 6356 14 revealed reveal VBD cord-010119-t1x9gknd 6356 15 an an DT cord-010119-t1x9gknd 6356 16 anti anti JJ cord-010119-t1x9gknd 6356 17 - - JJ cord-010119-t1x9gknd 6356 18 C. c. JJ cord-010119-t1x9gknd 6356 19 No no DT cord-010119-t1x9gknd 6356 20 additional additional JJ cord-010119-t1x9gknd 6356 21 clinically clinically RB cord-010119-t1x9gknd 6356 22 significant significant JJ cord-010119-t1x9gknd 6356 23 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6356 24 detected detect VBN cord-010119-t1x9gknd 6356 25 in in IN cord-010119-t1x9gknd 6356 26 the the DT cord-010119-t1x9gknd 6356 27 pre pre NN cord-010119-t1x9gknd 6356 28 - - JJ cord-010119-t1x9gknd 6356 29 or or CC cord-010119-t1x9gknd 6356 30 post post JJ cord-010119-t1x9gknd 6356 31 - - JJ cord-010119-t1x9gknd 6356 32 transfusion transfusion NN cord-010119-t1x9gknd 6356 33 samples sample NNS cord-010119-t1x9gknd 6356 34 using use VBG cord-010119-t1x9gknd 6356 35 PeG peg JJ cord-010119-t1x9gknd 6356 36 TM TM NNP cord-010119-t1x9gknd 6356 37 . . . cord-010119-t1x9gknd 6357 1 Conclusion conclusion NN cord-010119-t1x9gknd 6357 2 : : : cord-010119-t1x9gknd 6358 1 The the DT cord-010119-t1x9gknd 6358 2 patient patient NN cord-010119-t1x9gknd 6358 3 experienced experience VBD cord-010119-t1x9gknd 6358 4 an an DT cord-010119-t1x9gknd 6358 5 acute acute JJ cord-010119-t1x9gknd 6358 6 hemolytic hemolytic JJ cord-010119-t1x9gknd 6358 7 transfusion transfusion NN cord-010119-t1x9gknd 6358 8 reaction reaction NN cord-010119-t1x9gknd 6358 9 due due IN cord-010119-t1x9gknd 6358 10 to to IN cord-010119-t1x9gknd 6358 11 anamnestic anamnestic JJ cord-010119-t1x9gknd 6358 12 interaction interaction NN cord-010119-t1x9gknd 6358 13 of of IN cord-010119-t1x9gknd 6358 14 anti anti JJ cord-010119-t1x9gknd 6358 15 - - NNP cord-010119-t1x9gknd 6358 16 C C NNP cord-010119-t1x9gknd 6358 17 in in IN cord-010119-t1x9gknd 6358 18 the the DT cord-010119-t1x9gknd 6358 19 patient patient NN cord-010119-t1x9gknd 6358 20 's 's POS cord-010119-t1x9gknd 6358 21 plasma plasma NN cord-010119-t1x9gknd 6358 22 / / SYM cord-010119-t1x9gknd 6358 23 serum serum NN cord-010119-t1x9gknd 6358 24 against against IN cord-010119-t1x9gknd 6358 25 C C NNP cord-010119-t1x9gknd 6358 26 antigen antigen NN cord-010119-t1x9gknd 6358 27 on on IN cord-010119-t1x9gknd 6358 28 the the DT cord-010119-t1x9gknd 6358 29 transfused transfuse VBN cord-010119-t1x9gknd 6358 30 cells cell NNS cord-010119-t1x9gknd 6358 31 . . . cord-010119-t1x9gknd 6359 1 Anti Anti NNP cord-010119-t1x9gknd 6359 2 - - NNP cord-010119-t1x9gknd 6359 3 C C NNP cord-010119-t1x9gknd 6359 4 was be VBD cord-010119-t1x9gknd 6359 5 not not RB cord-010119-t1x9gknd 6359 6 detected detect VBN cord-010119-t1x9gknd 6359 7 by by IN cord-010119-t1x9gknd 6359 8 our -PRON- PRP$ cord-010119-t1x9gknd 6359 9 routine routine JJ cord-010119-t1x9gknd 6359 10 antibody antibody NN cord-010119-t1x9gknd 6359 11 identification identification NN cord-010119-t1x9gknd 6359 12 techniques technique NNS cord-010119-t1x9gknd 6359 13 . . . cord-010119-t1x9gknd 6360 1 The the DT cord-010119-t1x9gknd 6360 2 MMA MMA NNP cord-010119-t1x9gknd 6360 3 confirmed confirm VBD cord-010119-t1x9gknd 6360 4 anti anti JJ cord-010119-t1x9gknd 6360 5 - - JJ cord-010119-t1x9gknd 6360 6 E e JJ cord-010119-t1x9gknd 6360 7 , , , cord-010119-t1x9gknd 6360 8 -M -M : cord-010119-t1x9gknd 6360 9 and and CC cord-010119-t1x9gknd 6360 10 -C -C NNS cord-010119-t1x9gknd 6360 11 were be VBD cord-010119-t1x9gknd 6360 12 clinically clinically RB cord-010119-t1x9gknd 6360 13 significant significant JJ cord-010119-t1x9gknd 6360 14 . . . cord-010119-t1x9gknd 6361 1 Laura Laura NNP cord-010119-t1x9gknd 6361 2 Bailey Bailey NNP cord-010119-t1x9gknd 6361 3 * * NFP cord-010119-t1x9gknd 6361 4 1 1 CD cord-010119-t1x9gknd 6361 5 , , , cord-010119-t1x9gknd 6361 6 Melissa Melissa NNP cord-010119-t1x9gknd 6361 7 Grohotolsky Grohotolsky NNP cord-010119-t1x9gknd 6361 8 2 2 CD cord-010119-t1x9gknd 6361 9 , , , cord-010119-t1x9gknd 6361 10 Lisa Lisa NNP cord-010119-t1x9gknd 6361 11 DeBlass DeBlass NNP cord-010119-t1x9gknd 6361 12 1 1 CD cord-010119-t1x9gknd 6361 13 , , , cord-010119-t1x9gknd 6361 14 Bala Bala NNP cord-010119-t1x9gknd 6361 15 Carver Carver NNP cord-010119-t1x9gknd 6361 16 1 1 CD cord-010119-t1x9gknd 6361 17 and and CC cord-010119-t1x9gknd 6361 18 Kip Kip NNP cord-010119-t1x9gknd 6361 19 Kuttner Kuttner NNP cord-010119-t1x9gknd 6362 1 2 2 LS cord-010119-t1x9gknd 6362 2 . . . cord-010119-t1x9gknd 6362 3 1 1 CD cord-010119-t1x9gknd 6362 4 Health Health NNP cord-010119-t1x9gknd 6362 5 Network Network NNP cord-010119-t1x9gknd 6362 6 Laboratories Laboratories NNPS cord-010119-t1x9gknd 6362 7 , , , cord-010119-t1x9gknd 6362 8 2 2 CD cord-010119-t1x9gknd 6362 9 Miller Miller NNP cord-010119-t1x9gknd 6362 10 Keystone Keystone NNP cord-010119-t1x9gknd 6362 11 Blood Blood NNP cord-010119-t1x9gknd 6362 12 Center Center NNP cord-010119-t1x9gknd 6362 13 Background Background NNP cord-010119-t1x9gknd 6362 14 / / SYM cord-010119-t1x9gknd 6362 15 Case Case NNP cord-010119-t1x9gknd 6362 16 Studies Studies NNPS cord-010119-t1x9gknd 6362 17 : : : cord-010119-t1x9gknd 6363 1 The the DT cord-010119-t1x9gknd 6363 2 En En NNP cord-010119-t1x9gknd 6363 3 a a DT cord-010119-t1x9gknd 6363 4 antigen antigen NN cord-010119-t1x9gknd 6363 5 is be VBZ cord-010119-t1x9gknd 6363 6 a a DT cord-010119-t1x9gknd 6363 7 high high JJ cord-010119-t1x9gknd 6363 8 prevalence prevalence NN cord-010119-t1x9gknd 6363 9 antigen antigen NN cord-010119-t1x9gknd 6363 10 in in IN cord-010119-t1x9gknd 6363 11 the the DT cord-010119-t1x9gknd 6363 12 MNS MNS NNP cord-010119-t1x9gknd 6363 13 blood blood NN cord-010119-t1x9gknd 6363 14 group group NN cord-010119-t1x9gknd 6363 15 system system NN cord-010119-t1x9gknd 6363 16 . . . cord-010119-t1x9gknd 6364 1 The the DT cord-010119-t1x9gknd 6364 2 antigens antigen NNS cord-010119-t1x9gknd 6364 3 of of IN cord-010119-t1x9gknd 6364 4 the the DT cord-010119-t1x9gknd 6364 5 MNS MNS NNP cord-010119-t1x9gknd 6364 6 system system NN cord-010119-t1x9gknd 6364 7 are be VBP cord-010119-t1x9gknd 6364 8 carried carry VBN cord-010119-t1x9gknd 6364 9 on on IN cord-010119-t1x9gknd 6364 10 glycophorin glycophorin NNP cord-010119-t1x9gknd 6364 11 A A NNP cord-010119-t1x9gknd 6364 12 ( ( -LRB- cord-010119-t1x9gknd 6364 13 GPA GPA NNP cord-010119-t1x9gknd 6364 14 ) ) -RRB- cord-010119-t1x9gknd 6364 15 and and CC cord-010119-t1x9gknd 6364 16 glycophorin glycophorin NNP cord-010119-t1x9gknd 6364 17 B B NNP cord-010119-t1x9gknd 6364 18 ( ( -LRB- cord-010119-t1x9gknd 6364 19 GPB GPB NNP cord-010119-t1x9gknd 6364 20 ) ) -RRB- cord-010119-t1x9gknd 6364 21 . . . cord-010119-t1x9gknd 6365 1 Anti Anti NNP cord-010119-t1x9gknd 6365 2 - - JJ cord-010119-t1x9gknd 6365 3 En en JJ cord-010119-t1x9gknd 6365 4 a a NN cord-010119-t1x9gknd 6365 5 is be VBZ cord-010119-t1x9gknd 6365 6 a a DT cord-010119-t1x9gknd 6365 7 rare rare JJ cord-010119-t1x9gknd 6365 8 immune immune JJ cord-010119-t1x9gknd 6365 9 IgM IgM NNP cord-010119-t1x9gknd 6365 10 / / SYM cord-010119-t1x9gknd 6365 11 IgG IgG NNP cord-010119-t1x9gknd 6365 12 antibody antibody NN cord-010119-t1x9gknd 6365 13 made make VBN cord-010119-t1x9gknd 6365 14 by by IN cord-010119-t1x9gknd 6365 15 individuals individual NNS cord-010119-t1x9gknd 6365 16 who who WP cord-010119-t1x9gknd 6365 17 lack lack VBP cord-010119-t1x9gknd 6365 18 all all DT cord-010119-t1x9gknd 6365 19 or or CC cord-010119-t1x9gknd 6365 20 part part NN cord-010119-t1x9gknd 6365 21 of of IN cord-010119-t1x9gknd 6365 22 the the DT cord-010119-t1x9gknd 6365 23 GPA GPA NNP cord-010119-t1x9gknd 6365 24 protein protein NN cord-010119-t1x9gknd 6365 25 . . . cord-010119-t1x9gknd 6366 1 Anti Anti NNP cord-010119-t1x9gknd 6366 2 - - NNP cord-010119-t1x9gknd 6366 3 En En NNP cord-010119-t1x9gknd 6366 4 a a NN cord-010119-t1x9gknd 6366 5 has have VBZ cord-010119-t1x9gknd 6366 6 been be VBN cord-010119-t1x9gknd 6366 7 implicated implicate VBN cord-010119-t1x9gknd 6366 8 in in IN cord-010119-t1x9gknd 6366 9 fatal fatal JJ cord-010119-t1x9gknd 6366 10 HTR htr NN cord-010119-t1x9gknd 6366 11 and and CC cord-010119-t1x9gknd 6366 12 HDFN HDFN NNP cord-010119-t1x9gknd 6366 13 . . . cord-010119-t1x9gknd 6367 1 The the DT cord-010119-t1x9gknd 6367 2 En(a-)phenotype en(a-)phenotype NN cord-010119-t1x9gknd 6367 3 can can MD cord-010119-t1x9gknd 6367 4 result result VB cord-010119-t1x9gknd 6367 5 from from IN cord-010119-t1x9gknd 6367 6 either either CC cord-010119-t1x9gknd 6367 7 a a DT cord-010119-t1x9gknd 6367 8 rare rare JJ cord-010119-t1x9gknd 6367 9 deletion deletion NN cord-010119-t1x9gknd 6367 10 of of IN cord-010119-t1x9gknd 6367 11 the the DT cord-010119-t1x9gknd 6367 12 GPA GPA NNP cord-010119-t1x9gknd 6367 13 protein protein NN cord-010119-t1x9gknd 6367 14 or or CC cord-010119-t1x9gknd 6367 15 the the DT cord-010119-t1x9gknd 6367 16 even even RB cord-010119-t1x9gknd 6367 17 rarer rare JJR cord-010119-t1x9gknd 6367 18 M M NNP cord-010119-t1x9gknd 6367 19 k k NN cord-010119-t1x9gknd 6367 20 phenotype phenotype NN cord-010119-t1x9gknd 6367 21 . . . cord-010119-t1x9gknd 6368 1 Because because IN cord-010119-t1x9gknd 6368 2 individuals individual NNS cord-010119-t1x9gknd 6368 3 with with IN cord-010119-t1x9gknd 6368 4 the the DT cord-010119-t1x9gknd 6368 5 M M NNP cord-010119-t1x9gknd 6368 6 k k NNP cord-010119-t1x9gknd 6368 7 phenotype phenotype NN cord-010119-t1x9gknd 6368 8 lack lack NN cord-010119-t1x9gknd 6368 9 both both CC cord-010119-t1x9gknd 6368 10 the the DT cord-010119-t1x9gknd 6368 11 GPA GPA NNP cord-010119-t1x9gknd 6368 12 and and CC cord-010119-t1x9gknd 6368 13 GPB GPB NNP cord-010119-t1x9gknd 6368 14 protein protein NN cord-010119-t1x9gknd 6368 15 their -PRON- PRP$ cord-010119-t1x9gknd 6368 16 red red JJ cord-010119-t1x9gknd 6368 17 blood blood NN cord-010119-t1x9gknd 6368 18 cells cell NNS cord-010119-t1x9gknd 6368 19 type type NN cord-010119-t1x9gknd 6368 20 as as IN cord-010119-t1x9gknd 6368 21 M- M- NNP cord-010119-t1x9gknd 6368 22 , , , cord-010119-t1x9gknd 6368 23 N- N- NNP cord-010119-t1x9gknd 6368 24 , , , cord-010119-t1x9gknd 6368 25 S- S- NNP cord-010119-t1x9gknd 6368 26 , , , cord-010119-t1x9gknd 6368 27 s- s- XX cord-010119-t1x9gknd 6368 28 , , , cord-010119-t1x9gknd 6368 29 U- U- NNP cord-010119-t1x9gknd 6368 30 , , , cord-010119-t1x9gknd 6368 31 En(a- En(a- '' cord-010119-t1x9gknd 6368 32 ) ) -RRB- cord-010119-t1x9gknd 6368 33 , , , cord-010119-t1x9gknd 6368 34 Wr(b- Wr(b- NNS cord-010119-t1x9gknd 6368 35 ) ) -RRB- cord-010119-t1x9gknd 6368 36 and and CC cord-010119-t1x9gknd 6368 37 have have VBP cord-010119-t1x9gknd 6368 38 reduced reduce VBN cord-010119-t1x9gknd 6368 39 sialic sialic NN cord-010119-t1x9gknd 6368 40 acid acid NN cord-010119-t1x9gknd 6368 41 . . . cord-010119-t1x9gknd 6369 1 Study Study NNP cord-010119-t1x9gknd 6369 2 Design Design NNP cord-010119-t1x9gknd 6369 3 / / SYM cord-010119-t1x9gknd 6369 4 Method method NN cord-010119-t1x9gknd 6369 5 : : : cord-010119-t1x9gknd 6369 6 23 23 CD cord-010119-t1x9gknd 6369 7 year year NN cord-010119-t1x9gknd 6369 8 old old JJ cord-010119-t1x9gknd 6369 9 white white JJ cord-010119-t1x9gknd 6369 10 Mennonite mennonite JJ cord-010119-t1x9gknd 6369 11 female female JJ cord-010119-t1x9gknd 6369 12 G1,P0 G1,P0 NNP cord-010119-t1x9gknd 6369 13 presented present VBD cord-010119-t1x9gknd 6369 14 to to IN cord-010119-t1x9gknd 6369 15 her -PRON- PRP$ cord-010119-t1x9gknd 6369 16 midwife midwife NN cord-010119-t1x9gknd 6369 17 for for IN cord-010119-t1x9gknd 6369 18 prenatal prenatal JJ cord-010119-t1x9gknd 6369 19 care care NN cord-010119-t1x9gknd 6369 20 with with IN cord-010119-t1x9gknd 6369 21 the the DT cord-010119-t1x9gknd 6369 22 intent intent NN cord-010119-t1x9gknd 6369 23 of of IN cord-010119-t1x9gknd 6369 24 home home NN cord-010119-t1x9gknd 6369 25 delivery delivery NN cord-010119-t1x9gknd 6369 26 . . . cord-010119-t1x9gknd 6370 1 She -PRON- PRP cord-010119-t1x9gknd 6370 2 had have VBD cord-010119-t1x9gknd 6370 3 a a DT cord-010119-t1x9gknd 6370 4 positive positive JJ cord-010119-t1x9gknd 6370 5 antibody antibody NN cord-010119-t1x9gknd 6370 6 screen screen NN cord-010119-t1x9gknd 6370 7 by by IN cord-010119-t1x9gknd 6370 8 solid solid JJ cord-010119-t1x9gknd 6370 9 phase phase NN cord-010119-t1x9gknd 6370 10 at at IN cord-010119-t1x9gknd 6370 11 the the DT cord-010119-t1x9gknd 6370 12 hospital hospital NN cord-010119-t1x9gknd 6370 13 transfusion transfusion NN cord-010119-t1x9gknd 6370 14 service service NN cord-010119-t1x9gknd 6370 15 . . . cord-010119-t1x9gknd 6371 1 An an DT cord-010119-t1x9gknd 6371 2 antibody antibody NN cord-010119-t1x9gknd 6371 3 identification identification NN cord-010119-t1x9gknd 6371 4 panel panel NN cord-010119-t1x9gknd 6371 5 was be VBD cord-010119-t1x9gknd 6371 6 done do VBN cord-010119-t1x9gknd 6371 7 in in IN cord-010119-t1x9gknd 6371 8 gel gel NN cord-010119-t1x9gknd 6371 9 . . . cord-010119-t1x9gknd 6372 1 Testing test VBG cord-010119-t1x9gknd 6372 2 for for IN cord-010119-t1x9gknd 6372 3 antibodies antibody NNS cord-010119-t1x9gknd 6372 4 against against IN cord-010119-t1x9gknd 6372 5 selected select VBN cord-010119-t1x9gknd 6372 6 cells cell NNS cord-010119-t1x9gknd 6372 7 ( ( -LRB- cord-010119-t1x9gknd 6372 8 U U NNP cord-010119-t1x9gknd 6372 9 - - : cord-010119-t1x9gknd 6372 10 and and CC cord-010119-t1x9gknd 6372 11 U U NNP cord-010119-t1x9gknd 6372 12 var var NNP cord-010119-t1x9gknd 6372 13 ) ) -RRB- cord-010119-t1x9gknd 6372 14 in in IN cord-010119-t1x9gknd 6372 15 tube tube NN cord-010119-t1x9gknd 6372 16 with with IN cord-010119-t1x9gknd 6372 17 PEG PEG NNP cord-010119-t1x9gknd 6372 18 enhancement enhancement NN cord-010119-t1x9gknd 6372 19 and and CC cord-010119-t1x9gknd 6372 20 phenotyping phenotyping NN cord-010119-t1x9gknd 6372 21 was be VBD cord-010119-t1x9gknd 6372 22 done do VBN cord-010119-t1x9gknd 6372 23 . . . cord-010119-t1x9gknd 6373 1 Based base VBN cord-010119-t1x9gknd 6373 2 on on IN cord-010119-t1x9gknd 6373 3 MNS MNS NNP cord-010119-t1x9gknd 6373 4 phenotype phenotype NN cord-010119-t1x9gknd 6373 5 , , , cord-010119-t1x9gknd 6373 6 anti anti JJ cord-010119-t1x9gknd 6373 7 - - JJ cord-010119-t1x9gknd 6373 8 En en JJ cord-010119-t1x9gknd 6373 9 a a DT cord-010119-t1x9gknd 6373 10 was be VBD cord-010119-t1x9gknd 6373 11 suspected suspect VBN cord-010119-t1x9gknd 6373 12 . . . cord-010119-t1x9gknd 6374 1 The the DT cord-010119-t1x9gknd 6374 2 specimen specimen NN cord-010119-t1x9gknd 6374 3 was be VBD cord-010119-t1x9gknd 6374 4 referred refer VBN cord-010119-t1x9gknd 6374 5 to to IN cord-010119-t1x9gknd 6374 6 an an DT cord-010119-t1x9gknd 6374 7 immunohematology immunohematology NN cord-010119-t1x9gknd 6374 8 reference reference NN cord-010119-t1x9gknd 6374 9 laboratory laboratory NN cord-010119-t1x9gknd 6374 10 ( ( -LRB- cord-010119-t1x9gknd 6374 11 IRL IRL NNP cord-010119-t1x9gknd 6374 12 ) ) -RRB- cord-010119-t1x9gknd 6374 13 . . . cord-010119-t1x9gknd 6375 1 The the DT cord-010119-t1x9gknd 6375 2 testing testing NN cord-010119-t1x9gknd 6375 3 included include VBD cord-010119-t1x9gknd 6375 4 phenotyping phenotyping NN cord-010119-t1x9gknd 6375 5 with with IN cord-010119-t1x9gknd 6375 6 unlicensed unlicensed JJ cord-010119-t1x9gknd 6375 7 antisera antisera NN cord-010119-t1x9gknd 6375 8 , , , cord-010119-t1x9gknd 6375 9 ficin ficin NNS cord-010119-t1x9gknd 6375 10 treated treat VBN cord-010119-t1x9gknd 6375 11 panels panel NNS cord-010119-t1x9gknd 6375 12 by by IN cord-010119-t1x9gknd 6375 13 tube tube NN cord-010119-t1x9gknd 6375 14 technique technique NN cord-010119-t1x9gknd 6375 15 , , , cord-010119-t1x9gknd 6375 16 allogeneic allogeneic NN cord-010119-t1x9gknd 6375 17 adsorptions adsorption NNS cord-010119-t1x9gknd 6375 18 for for IN cord-010119-t1x9gknd 6375 19 antibody antibody NN cord-010119-t1x9gknd 6375 20 exclusion exclusion NN cord-010119-t1x9gknd 6375 21 and and CC cord-010119-t1x9gknd 6375 22 identification identification NN cord-010119-t1x9gknd 6375 23 and and CC cord-010119-t1x9gknd 6375 24 antibody antibody NN cord-010119-t1x9gknd 6375 25 titration titration NN cord-010119-t1x9gknd 6375 26 . . . cord-010119-t1x9gknd 6376 1 Following follow VBG cord-010119-t1x9gknd 6376 2 identification identification NN cord-010119-t1x9gknd 6376 3 of of IN cord-010119-t1x9gknd 6376 4 anti anti JJ cord-010119-t1x9gknd 6376 5 - - JJ cord-010119-t1x9gknd 6376 6 En en JJ cord-010119-t1x9gknd 6376 7 a a NN cord-010119-t1x9gknd 6376 8 by by IN cord-010119-t1x9gknd 6376 9 the the DT cord-010119-t1x9gknd 6376 10 IRL IRL NNP cord-010119-t1x9gknd 6377 1 the the DT cord-010119-t1x9gknd 6377 2 midwife midwife NN cord-010119-t1x9gknd 6377 3 was be VBD cord-010119-t1x9gknd 6377 4 advised advise VBN cord-010119-t1x9gknd 6377 5 to to TO cord-010119-t1x9gknd 6377 6 refer refer VB cord-010119-t1x9gknd 6377 7 the the DT cord-010119-t1x9gknd 6377 8 patient patient NN cord-010119-t1x9gknd 6377 9 to to IN cord-010119-t1x9gknd 6377 10 a a DT cord-010119-t1x9gknd 6377 11 maternal maternal JJ cord-010119-t1x9gknd 6377 12 fetal fetal JJ cord-010119-t1x9gknd 6377 13 medicine medicine NN cord-010119-t1x9gknd 6377 14 specialist specialist NN cord-010119-t1x9gknd 6377 15 at at IN cord-010119-t1x9gknd 6377 16 an an DT cord-010119-t1x9gknd 6377 17 academic academic JJ cord-010119-t1x9gknd 6377 18 center center NN cord-010119-t1x9gknd 6377 19 close close RB cord-010119-t1x9gknd 6377 20 to to IN cord-010119-t1x9gknd 6377 21 the the DT cord-010119-t1x9gknd 6377 22 patients patient NNS cord-010119-t1x9gknd 6377 23 ' ' POS cord-010119-t1x9gknd 6377 24 home home NN cord-010119-t1x9gknd 6377 25 . . . cord-010119-t1x9gknd 6378 1 The the DT cord-010119-t1x9gknd 6378 2 midwife midwife NN cord-010119-t1x9gknd 6378 3 was be VBD cord-010119-t1x9gknd 6378 4 also also RB cord-010119-t1x9gknd 6378 5 advised advise VBN cord-010119-t1x9gknd 6378 6 to to TO cord-010119-t1x9gknd 6378 7 consider consider VB cord-010119-t1x9gknd 6378 8 autologous autologous JJ cord-010119-t1x9gknd 6378 9 blood blood NN cord-010119-t1x9gknd 6378 10 donation donation NN cord-010119-t1x9gknd 6378 11 and and CC cord-010119-t1x9gknd 6378 12 /or /or . cord-010119-t1x9gknd 6378 13 testing testing NN cord-010119-t1x9gknd 6378 14 of of IN cord-010119-t1x9gknd 6378 15 siblings sibling NNS cord-010119-t1x9gknd 6378 16 . . . cord-010119-t1x9gknd 6379 1 Results/ Results/ . cord-010119-t1x9gknd 6380 1 Finding finding NN cord-010119-t1x9gknd 6380 2 : : : cord-010119-t1x9gknd 6381 1 Testing testing NN cord-010119-t1x9gknd 6381 2 by by IN cord-010119-t1x9gknd 6381 3 the the DT cord-010119-t1x9gknd 6381 4 hospital hospital NN cord-010119-t1x9gknd 6381 5 blood blood NN cord-010119-t1x9gknd 6381 6 bank bank NNP cord-010119-t1x9gknd 6381 7 demonstrated demonstrate VBD cord-010119-t1x9gknd 6381 8 positive positive JJ cord-010119-t1x9gknd 6381 9 reactivity reactivity NN cord-010119-t1x9gknd 6381 10 in in IN cord-010119-t1x9gknd 6381 11 the the DT cord-010119-t1x9gknd 6381 12 antibody antibody NN cord-010119-t1x9gknd 6381 13 screen screen NN cord-010119-t1x9gknd 6381 14 . . . cord-010119-t1x9gknd 6382 1 The the DT cord-010119-t1x9gknd 6382 2 gel gel NN cord-010119-t1x9gknd 6382 3 antibody antibody NN cord-010119-t1x9gknd 6382 4 panel panel NN cord-010119-t1x9gknd 6382 5 AHG AHG NNP cord-010119-t1x9gknd 6382 6 phase phase NN cord-010119-t1x9gknd 6382 7 resulted result VBD cord-010119-t1x9gknd 6382 8 in in IN cord-010119-t1x9gknd 6382 9 21 21 CD cord-010119-t1x9gknd 6382 10 panagglutination panagglutination NN cord-010119-t1x9gknd 6382 11 and and CC cord-010119-t1x9gknd 6382 12 a a DT cord-010119-t1x9gknd 6382 13 negative negative JJ cord-010119-t1x9gknd 6382 14 autocontrol autocontrol NN cord-010119-t1x9gknd 6382 15 , , , cord-010119-t1x9gknd 6382 16 suggesting suggest VBG cord-010119-t1x9gknd 6382 17 a a DT cord-010119-t1x9gknd 6382 18 high high JJ cord-010119-t1x9gknd 6382 19 prevalence prevalence NN cord-010119-t1x9gknd 6382 20 antibody antibody NN cord-010119-t1x9gknd 6382 21 . . . cord-010119-t1x9gknd 6383 1 The the DT cord-010119-t1x9gknd 6383 2 phenotype phenotype NN cord-010119-t1x9gknd 6383 3 was be VBD cord-010119-t1x9gknd 6383 4 performed perform VBN cord-010119-t1x9gknd 6383 5 and and CC cord-010119-t1x9gknd 6383 6 determined determine VBN cord-010119-t1x9gknd 6383 7 to to TO cord-010119-t1x9gknd 6383 8 be be VB cord-010119-t1x9gknd 6383 9 M- m- XX cord-010119-t1x9gknd 6383 10 , , , cord-010119-t1x9gknd 6383 11 N- N- NNP cord-010119-t1x9gknd 6383 12 , , , cord-010119-t1x9gknd 6383 13 S- S- NNP cord-010119-t1x9gknd 6383 14 , , , cord-010119-t1x9gknd 6383 15 s- s- XX cord-010119-t1x9gknd 6383 16 , , , cord-010119-t1x9gknd 6383 17 U U NNP cord-010119-t1x9gknd 6383 18 - - HYPH cord-010119-t1x9gknd 6383 19 . . . cord-010119-t1x9gknd 6384 1 Outdated outdated JJ cord-010119-t1x9gknd 6384 2 U U NNP cord-010119-t1x9gknd 6384 3 variant variant NN cord-010119-t1x9gknd 6384 4 reagent reagent NN cord-010119-t1x9gknd 6384 5 cells cell NNS cord-010119-t1x9gknd 6384 6 reacted react VBD cord-010119-t1x9gknd 6384 7 in in IN cord-010119-t1x9gknd 6384 8 PEG PEG NNP cord-010119-t1x9gknd 6384 9 IgG igg NN cord-010119-t1x9gknd 6384 10 phase phase NN cord-010119-t1x9gknd 6384 11 ruling rule VBG cord-010119-t1x9gknd 6384 12 out out RP cord-010119-t1x9gknd 6384 13 anti anti JJ cord-010119-t1x9gknd 6384 14 - - NNP cord-010119-t1x9gknd 6384 15 U. U. NNP cord-010119-t1x9gknd 6384 16 Anti Anti NNP cord-010119-t1x9gknd 6384 17 - - HYPH cord-010119-t1x9gknd 6384 18 En En NNP cord-010119-t1x9gknd 6384 19 a a DT cord-010119-t1x9gknd 6384 20 was be VBD cord-010119-t1x9gknd 6384 21 suspected suspect VBN cord-010119-t1x9gknd 6384 22 and and CC cord-010119-t1x9gknd 6384 23 the the DT cord-010119-t1x9gknd 6384 24 sample sample NN cord-010119-t1x9gknd 6384 25 was be VBD cord-010119-t1x9gknd 6384 26 referred refer VBN cord-010119-t1x9gknd 6384 27 to to IN cord-010119-t1x9gknd 6384 28 the the DT cord-010119-t1x9gknd 6384 29 IRL IRL NNP cord-010119-t1x9gknd 6384 30 . . . cord-010119-t1x9gknd 6385 1 Allogeneic Allogeneic NNP cord-010119-t1x9gknd 6385 2 adsorptions adsorption NNS cord-010119-t1x9gknd 6385 3 were be VBD cord-010119-t1x9gknd 6385 4 performed perform VBN cord-010119-t1x9gknd 6385 5 to to TO cord-010119-t1x9gknd 6385 6 rule rule VB cord-010119-t1x9gknd 6385 7 out out RP cord-010119-t1x9gknd 6385 8 antibodies antibody NNS cord-010119-t1x9gknd 6385 9 to to IN cord-010119-t1x9gknd 6385 10 common common JJ cord-010119-t1x9gknd 6385 11 red red JJ cord-010119-t1x9gknd 6385 12 cell cell NN cord-010119-t1x9gknd 6385 13 antigens antigen NNS cord-010119-t1x9gknd 6385 14 . . . cord-010119-t1x9gknd 6386 1 Lack lack NN cord-010119-t1x9gknd 6386 2 of of IN cord-010119-t1x9gknd 6386 3 reactivity reactivity NN cord-010119-t1x9gknd 6386 4 on on IN cord-010119-t1x9gknd 6386 5 a a DT cord-010119-t1x9gknd 6386 6 ficin ficin NNS cord-010119-t1x9gknd 6386 7 panel panel NN cord-010119-t1x9gknd 6386 8 eliminated eliminate VBD cord-010119-t1x9gknd 6386 9 the the DT cord-010119-t1x9gknd 6386 10 presence presence NN cord-010119-t1x9gknd 6386 11 of of IN cord-010119-t1x9gknd 6386 12 anti anti JJ cord-010119-t1x9gknd 6386 13 - - JJ cord-010119-t1x9gknd 6386 14 U,-Wr u,-wr JJ cord-010119-t1x9gknd 6386 15 b b NN cord-010119-t1x9gknd 6386 16 . . . cord-010119-t1x9gknd 6387 1 Phenotyping phenotype VBG cord-010119-t1x9gknd 6387 2 with with IN cord-010119-t1x9gknd 6387 3 unlicensed unlicensed JJ cord-010119-t1x9gknd 6387 4 anti anti NNS cord-010119-t1x9gknd 6387 5 - - NNP cord-010119-t1x9gknd 6387 6 U U NNP cord-010119-t1x9gknd 6387 7 was be VBD cord-010119-t1x9gknd 6387 8 negative negative JJ cord-010119-t1x9gknd 6387 9 and and CC cord-010119-t1x9gknd 6387 10 unlicensed unlicensed JJ cord-010119-t1x9gknd 6387 11 Glycine Glycine NNP cord-010119-t1x9gknd 6387 12 Soja Soja NNP cord-010119-t1x9gknd 6387 13 demonstrated demonstrate VBD cord-010119-t1x9gknd 6387 14 11 11 CD cord-010119-t1x9gknd 6387 15 reactivity reactivity NN cord-010119-t1x9gknd 6387 16 , , , cord-010119-t1x9gknd 6387 17 suggesting suggest VBG cord-010119-t1x9gknd 6387 18 that that IN cord-010119-t1x9gknd 6387 19 the the DT cord-010119-t1x9gknd 6387 20 patient patient NN cord-010119-t1x9gknd 6387 21 is be VBZ cord-010119-t1x9gknd 6387 22 En(a- en(a- CD cord-010119-t1x9gknd 6387 23 ) ) -RRB- cord-010119-t1x9gknd 6387 24 . . . cord-010119-t1x9gknd 6388 1 The the DT cord-010119-t1x9gknd 6388 2 patient patient NN cord-010119-t1x9gknd 6388 3 's 's POS cord-010119-t1x9gknd 6388 4 phenotype phenotype NN cord-010119-t1x9gknd 6388 5 is be VBZ cord-010119-t1x9gknd 6388 6 consistent consistent JJ cord-010119-t1x9gknd 6388 7 with with IN cord-010119-t1x9gknd 6388 8 the the DT cord-010119-t1x9gknd 6388 9 M M NNP cord-010119-t1x9gknd 6388 10 k k NNP cord-010119-t1x9gknd 6388 11 phenotype phenotype NN cord-010119-t1x9gknd 6388 12 . . . cord-010119-t1x9gknd 6389 1 Based base VBN cord-010119-t1x9gknd 6389 2 on on IN cord-010119-t1x9gknd 6389 3 the the DT cord-010119-t1x9gknd 6389 4 lack lack NN cord-010119-t1x9gknd 6389 5 of of IN cord-010119-t1x9gknd 6389 6 reactivity reactivity NN cord-010119-t1x9gknd 6389 7 on on IN cord-010119-t1x9gknd 6389 8 the the DT cord-010119-t1x9gknd 6389 9 ficin ficin NNS cord-010119-t1x9gknd 6389 10 panel panel NN cord-010119-t1x9gknd 6389 11 , , , cord-010119-t1x9gknd 6389 12 the the DT cord-010119-t1x9gknd 6389 13 antibody antibody NN cord-010119-t1x9gknd 6389 14 was be VBD cord-010119-t1x9gknd 6389 15 identified identify VBN cord-010119-t1x9gknd 6389 16 as as IN cord-010119-t1x9gknd 6389 17 anti anti JJ cord-010119-t1x9gknd 6389 18 - - JJ cord-010119-t1x9gknd 6389 19 En en JJ cord-010119-t1x9gknd 6389 20 a a DT cord-010119-t1x9gknd 6389 21 FS fs NN cord-010119-t1x9gknd 6389 22 . . . cord-010119-t1x9gknd 6390 1 Since since IN cord-010119-t1x9gknd 6390 2 anti anti JJ cord-010119-t1x9gknd 6390 3 - - JJ cord-010119-t1x9gknd 6390 4 En en JJ cord-010119-t1x9gknd 6390 5 a a NN cord-010119-t1x9gknd 6390 6 is be VBZ cord-010119-t1x9gknd 6390 7 extremely extremely RB cord-010119-t1x9gknd 6390 8 rare rare JJ cord-010119-t1x9gknd 6390 9 , , , cord-010119-t1x9gknd 6390 10 this this DT cord-010119-t1x9gknd 6390 11 specificity specificity NN cord-010119-t1x9gknd 6390 12 could could MD cord-010119-t1x9gknd 6390 13 not not RB cord-010119-t1x9gknd 6390 14 be be VB cord-010119-t1x9gknd 6390 15 confirmed confirm VBN cord-010119-t1x9gknd 6390 16 due due IN cord-010119-t1x9gknd 6390 17 to to IN cord-010119-t1x9gknd 6390 18 the the DT cord-010119-t1x9gknd 6390 19 lack lack NN cord-010119-t1x9gknd 6390 20 of of IN cord-010119-t1x9gknd 6390 21 En(a- en(a- CD cord-010119-t1x9gknd 6390 22 ) ) -RRB- cord-010119-t1x9gknd 6390 23 cells cell NNS cord-010119-t1x9gknd 6390 24 and and CC cord-010119-t1x9gknd 6390 25 appropriate appropriate JJ cord-010119-t1x9gknd 6390 26 antisera antisera NN cord-010119-t1x9gknd 6390 27 . . . cord-010119-t1x9gknd 6391 1 The the DT cord-010119-t1x9gknd 6391 2 baseline baseline JJ cord-010119-t1x9gknd 6391 3 antibody antibody NN cord-010119-t1x9gknd 6391 4 titer titer NN cord-010119-t1x9gknd 6391 5 was be VBD cord-010119-t1x9gknd 6391 6 2 2 CD cord-010119-t1x9gknd 6391 7 at at IN cord-010119-t1x9gknd 6391 8 IgG igg NN cord-010119-t1x9gknd 6391 9 phase phase NN cord-010119-t1x9gknd 6391 10 without without IN cord-010119-t1x9gknd 6391 11 enhancement enhancement NN cord-010119-t1x9gknd 6391 12 . . . cord-010119-t1x9gknd 6392 1 Conclusion conclusion NN cord-010119-t1x9gknd 6392 2 : : : cord-010119-t1x9gknd 6393 1 This this DT cord-010119-t1x9gknd 6393 2 case case NN cord-010119-t1x9gknd 6393 3 study study NN cord-010119-t1x9gknd 6393 4 describes describe VBZ cord-010119-t1x9gknd 6393 5 the the DT cord-010119-t1x9gknd 6393 6 workup workup NN cord-010119-t1x9gknd 6393 7 of of IN cord-010119-t1x9gknd 6393 8 a a DT cord-010119-t1x9gknd 6393 9 rare rare JJ cord-010119-t1x9gknd 6393 10 antibody antibody NN cord-010119-t1x9gknd 6393 11 in in IN cord-010119-t1x9gknd 6393 12 a a DT cord-010119-t1x9gknd 6393 13 prenatal prenatal JJ cord-010119-t1x9gknd 6393 14 patient patient NN cord-010119-t1x9gknd 6393 15 at at IN cord-010119-t1x9gknd 6393 16 a a DT cord-010119-t1x9gknd 6393 17 tertiary tertiary JJ cord-010119-t1x9gknd 6393 18 care care NN cord-010119-t1x9gknd 6393 19 hospital hospital NN cord-010119-t1x9gknd 6393 20 . . . cord-010119-t1x9gknd 6394 1 Studies study NNS cord-010119-t1x9gknd 6394 2 performed perform VBN cord-010119-t1x9gknd 6394 3 after after IN cord-010119-t1x9gknd 6394 4 the the DT cord-010119-t1x9gknd 6394 5 patient patient NN cord-010119-t1x9gknd 6394 6 was be VBD cord-010119-t1x9gknd 6394 7 transferred transfer VBN cord-010119-t1x9gknd 6394 8 closer close RBR cord-010119-t1x9gknd 6394 9 to to IN cord-010119-t1x9gknd 6394 10 home home NN cord-010119-t1x9gknd 6395 1 confirmed confirm VBD cord-010119-t1x9gknd 6395 2 the the DT cord-010119-t1x9gknd 6395 3 anti anti JJ cord-010119-t1x9gknd 6395 4 - - JJ cord-010119-t1x9gknd 6395 5 En en JJ cord-010119-t1x9gknd 6395 6 a a DT cord-010119-t1x9gknd 6395 7 ( ( -LRB- cord-010119-t1x9gknd 6395 8 FS fs NN cord-010119-t1x9gknd 6395 9 ) ) -RRB- cord-010119-t1x9gknd 6395 10 and and CC cord-010119-t1x9gknd 6395 11 genotyping genotyping NN cord-010119-t1x9gknd 6395 12 was be VBD cord-010119-t1x9gknd 6395 13 performed perform VBN cord-010119-t1x9gknd 6395 14 . . . cord-010119-t1x9gknd 6396 1 Three three CD cord-010119-t1x9gknd 6396 2 titers titer NNS cord-010119-t1x9gknd 6396 3 were be VBD cord-010119-t1x9gknd 6396 4 performed perform VBN cord-010119-t1x9gknd 6396 5 for for IN cord-010119-t1x9gknd 6396 6 the the DT cord-010119-t1x9gknd 6396 7 remainder remainder NN cord-010119-t1x9gknd 6396 8 of of IN cord-010119-t1x9gknd 6396 9 the the DT cord-010119-t1x9gknd 6396 10 pregnancy pregnancy NN cord-010119-t1x9gknd 6396 11 and and CC cord-010119-t1x9gknd 6396 12 held hold VBD cord-010119-t1x9gknd 6396 13 at at IN cord-010119-t1x9gknd 6396 14 2 2 CD cord-010119-t1x9gknd 6396 15 . . . cord-010119-t1x9gknd 6397 1 Although although IN cord-010119-t1x9gknd 6397 2 anti anti JJ cord-010119-t1x9gknd 6397 3 - - JJ cord-010119-t1x9gknd 6397 4 En en JJ cord-010119-t1x9gknd 6397 5 a a NN cord-010119-t1x9gknd 6397 6 has have VBZ cord-010119-t1x9gknd 6397 7 been be VBN cord-010119-t1x9gknd 6397 8 implicated implicate VBN cord-010119-t1x9gknd 6397 9 in in IN cord-010119-t1x9gknd 6397 10 HDFN HDFN NNP cord-010119-t1x9gknd 6397 11 , , , cord-010119-t1x9gknd 6397 12 a a DT cord-010119-t1x9gknd 6397 13 healthy healthy JJ cord-010119-t1x9gknd 6397 14 infant infant NN cord-010119-t1x9gknd 6397 15 was be VBD cord-010119-t1x9gknd 6397 16 delivered deliver VBN cord-010119-t1x9gknd 6397 17 without without IN cord-010119-t1x9gknd 6397 18 complications complication NNS cord-010119-t1x9gknd 6397 19 . . . cord-010119-t1x9gknd 6398 1 This this DT cord-010119-t1x9gknd 6398 2 patient patient NN cord-010119-t1x9gknd 6398 3 should should MD cord-010119-t1x9gknd 6398 4 be be VB cord-010119-t1x9gknd 6398 5 monitored monitor VBN cord-010119-t1x9gknd 6398 6 closely closely RB cord-010119-t1x9gknd 6398 7 through through IN cord-010119-t1x9gknd 6398 8 future future JJ cord-010119-t1x9gknd 6398 9 pregnancies pregnancy NNS cord-010119-t1x9gknd 6398 10 . . . cord-010119-t1x9gknd 6399 1 Autologous autologous JJ cord-010119-t1x9gknd 6399 2 donation donation NN cord-010119-t1x9gknd 6400 1 and/or and/or CC cord-010119-t1x9gknd 6400 2 sibling sibling NN cord-010119-t1x9gknd 6400 3 testing testing NN cord-010119-t1x9gknd 6400 4 should should MD cord-010119-t1x9gknd 6400 5 be be VB cord-010119-t1x9gknd 6400 6 considered consider VBN cord-010119-t1x9gknd 6400 7 in in IN cord-010119-t1x9gknd 6400 8 order order NN cord-010119-t1x9gknd 6400 9 to to TO cord-010119-t1x9gknd 6400 10 provide provide VB cord-010119-t1x9gknd 6400 11 compatible compatible JJ cord-010119-t1x9gknd 6400 12 blood blood NN cord-010119-t1x9gknd 6400 13 for for IN cord-010119-t1x9gknd 6400 14 intrauterine intrauterine JJ cord-010119-t1x9gknd 6400 15 transfusion transfusion NN cord-010119-t1x9gknd 6400 16 or or CC cord-010119-t1x9gknd 6400 17 transfusions transfusion NNS cord-010119-t1x9gknd 6400 18 at at IN cord-010119-t1x9gknd 6400 19 or or CC cord-010119-t1x9gknd 6400 20 after after IN cord-010119-t1x9gknd 6400 21 delivery delivery NN cord-010119-t1x9gknd 6400 22 . . . cord-010119-t1x9gknd 6401 1 Background Background NNP cord-010119-t1x9gknd 6401 2 / / SYM cord-010119-t1x9gknd 6401 3 Case Case NNP cord-010119-t1x9gknd 6401 4 Studies Studies NNPS cord-010119-t1x9gknd 6401 5 : : : cord-010119-t1x9gknd 6402 1 A a DT cord-010119-t1x9gknd 6402 2 15 15 CD cord-010119-t1x9gknd 6402 3 year year NN cord-010119-t1x9gknd 6402 4 old old JJ cord-010119-t1x9gknd 6402 5 Caucasian caucasian JJ cord-010119-t1x9gknd 6402 6 male male NN cord-010119-t1x9gknd 6402 7 diagnosed diagnose VBN cord-010119-t1x9gknd 6402 8 with with IN cord-010119-t1x9gknd 6402 9 hemolytic hemolytic JJ cord-010119-t1x9gknd 6402 10 anemia anemia NN cord-010119-t1x9gknd 6402 11 and and CC cord-010119-t1x9gknd 6402 12 no no DT cord-010119-t1x9gknd 6402 13 previous previous JJ cord-010119-t1x9gknd 6402 14 transfusions transfusion NNS cord-010119-t1x9gknd 6402 15 was be VBD cord-010119-t1x9gknd 6402 16 referred refer VBN cord-010119-t1x9gknd 6402 17 to to IN cord-010119-t1x9gknd 6402 18 the the DT cord-010119-t1x9gknd 6402 19 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 6402 20 Reference Reference NNP cord-010119-t1x9gknd 6402 21 Laboratory Laboratory NNP cord-010119-t1x9gknd 6402 22 ( ( -LRB- cord-010119-t1x9gknd 6402 23 IRL IRL NNP cord-010119-t1x9gknd 6402 24 ) ) -RRB- cord-010119-t1x9gknd 6402 25 for for IN cord-010119-t1x9gknd 6402 26 antibody antibody NN cord-010119-t1x9gknd 6402 27 identification identification NN cord-010119-t1x9gknd 6402 28 and and CC cord-010119-t1x9gknd 6402 29 RBC RBC NNP cord-010119-t1x9gknd 6402 30 genotyping genotyping NN cord-010119-t1x9gknd 6402 31 . . . cord-010119-t1x9gknd 6403 1 Initial initial JJ cord-010119-t1x9gknd 6403 2 serologic serologic NN cord-010119-t1x9gknd 6403 3 testing testing NN cord-010119-t1x9gknd 6403 4 by by IN cord-010119-t1x9gknd 6403 5 the the DT cord-010119-t1x9gknd 6403 6 referring refer VBG cord-010119-t1x9gknd 6403 7 facility facility NN cord-010119-t1x9gknd 6403 8 and and CC cord-010119-t1x9gknd 6404 1 the the DT cord-010119-t1x9gknd 6404 2 IRL IRL NNP cord-010119-t1x9gknd 6404 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 6404 4 anti anti JJ cord-010119-t1x9gknd 6404 5 - - JJ cord-010119-t1x9gknd 6404 6 D d JJ cord-010119-t1x9gknd 6404 7 , , , cord-010119-t1x9gknd 6404 8 anti anti JJ cord-010119-t1x9gknd 6404 9 - - NN cord-010119-t1x9gknd 6404 10 C c JJ cord-010119-t1x9gknd 6404 11 and/or and/or CC cord-010119-t1x9gknd 6404 12 anti anti JJ cord-010119-t1x9gknd 6404 13 - - JJ cord-010119-t1x9gknd 6404 14 G g JJ cord-010119-t1x9gknd 6404 15 specificity specificity NN cord-010119-t1x9gknd 6404 16 with with IN cord-010119-t1x9gknd 6404 17 a a DT cord-010119-t1x9gknd 6404 18 positive positive JJ cord-010119-t1x9gknd 6404 19 auto auto NN cord-010119-t1x9gknd 6404 20 control control NN cord-010119-t1x9gknd 6404 21 and and CC cord-010119-t1x9gknd 6404 22 IgG IgG NNP cord-010119-t1x9gknd 6404 23 DAT DAT NNP cord-010119-t1x9gknd 6404 24 . . . cord-010119-t1x9gknd 6405 1 Anti Anti NNP cord-010119-t1x9gknd 6405 2 - - NNP cord-010119-t1x9gknd 6405 3 G G NNP cord-010119-t1x9gknd 6405 4 has have VBZ cord-010119-t1x9gknd 6405 5 an an DT cord-010119-t1x9gknd 6405 6 anti anti JJ cord-010119-t1x9gknd 6405 7 - - JJ cord-010119-t1x9gknd 6405 8 D d JJ cord-010119-t1x9gknd 6405 9 , , , cord-010119-t1x9gknd 6405 10 -C -C VBZ cord-010119-t1x9gknd 6405 11 specificity specificity NN cord-010119-t1x9gknd 6405 12 and and CC cord-010119-t1x9gknd 6405 13 is be VBZ cord-010119-t1x9gknd 6405 14 most most RBS cord-010119-t1x9gknd 6405 15 frequently frequently RB cord-010119-t1x9gknd 6405 16 found find VBN cord-010119-t1x9gknd 6405 17 in in IN cord-010119-t1x9gknd 6405 18 rr rr NN cord-010119-t1x9gknd 6405 19 individuals individual NNS cord-010119-t1x9gknd 6405 20 exposed expose VBN cord-010119-t1x9gknd 6405 21 to to IN cord-010119-t1x9gknd 6405 22 r'r r'r NNP cord-010119-t1x9gknd 6405 23 cells cell NNS cord-010119-t1x9gknd 6405 24 . . . cord-010119-t1x9gknd 6406 1 The the DT cord-010119-t1x9gknd 6406 2 G g NN cord-010119-t1x9gknd 6406 3 antigen antigen NN cord-010119-t1x9gknd 6406 4 is be VBZ cord-010119-t1x9gknd 6406 5 present present JJ cord-010119-t1x9gknd 6406 6 on on IN cord-010119-t1x9gknd 6406 7 RBCs rbc NNS cord-010119-t1x9gknd 6406 8 expressing express VBG cord-010119-t1x9gknd 6406 9 either either CC cord-010119-t1x9gknd 6406 10 RhD rhd NN cord-010119-t1x9gknd 6406 11 and/or and/or CC cord-010119-t1x9gknd 6406 12 C C NNP cord-010119-t1x9gknd 6406 13 and and CC cord-010119-t1x9gknd 6406 14 very very RB cord-010119-t1x9gknd 6406 15 rarely rarely RB cord-010119-t1x9gknd 6406 16 on on IN cord-010119-t1x9gknd 6406 17 D D NNP cord-010119-t1x9gknd 6406 18 - - HYPH cord-010119-t1x9gknd 6406 19 C C NNP cord-010119-t1x9gknd 6406 20 - - HYPH cord-010119-t1x9gknd 6406 21 G1 G1 NNP cord-010119-t1x9gknd 6406 22 ( ( -LRB- cord-010119-t1x9gknd 6406 23 r r NN cord-010119-t1x9gknd 6406 24 G g NN cord-010119-t1x9gknd 6406 25 r r NN cord-010119-t1x9gknd 6406 26 ) ) -RRB- cord-010119-t1x9gknd 6406 27 cells cell NNS cord-010119-t1x9gknd 6406 28 . . . cord-010119-t1x9gknd 6407 1 Both both DT cord-010119-t1x9gknd 6407 2 RHCE*C rhce*c CD cord-010119-t1x9gknd 6407 3 and and CC cord-010119-t1x9gknd 6407 4 RHD RHD NNP cord-010119-t1x9gknd 6407 5 genes gene NNS cord-010119-t1x9gknd 6407 6 encode encode VBP cord-010119-t1x9gknd 6407 7 Ser103 ser103 CD cord-010119-t1x9gknd 6407 8 which which WDT cord-010119-t1x9gknd 6407 9 determines determine VBZ cord-010119-t1x9gknd 6407 10 G g NN cord-010119-t1x9gknd 6407 11 expression expression NN cord-010119-t1x9gknd 6407 12 . . . cord-010119-t1x9gknd 6408 1 Rare rare JJ cord-010119-t1x9gknd 6408 2 RhD rhd NN cord-010119-t1x9gknd 6408 3 variant variant NN cord-010119-t1x9gknd 6408 4 antigens antigen NNS cord-010119-t1x9gknd 6408 5 lacking lack VBG cord-010119-t1x9gknd 6408 6 Ser103 ser103 CD cord-010119-t1x9gknd 6408 7 are be VBP cord-010119-t1x9gknd 6408 8 G- g- JJ cord-010119-t1x9gknd 6408 9 . . . cord-010119-t1x9gknd 6409 1 Study Study NNP cord-010119-t1x9gknd 6409 2 Design Design NNP cord-010119-t1x9gknd 6409 3 / / SYM cord-010119-t1x9gknd 6409 4 Methods method NNS cord-010119-t1x9gknd 6409 5 : : : cord-010119-t1x9gknd 6410 1 Serologic Serologic NNP cord-010119-t1x9gknd 6410 2 evaluation evaluation NN cord-010119-t1x9gknd 6410 3 included include VBD cord-010119-t1x9gknd 6410 4 tube tube NN cord-010119-t1x9gknd 6410 5 testing testing NN cord-010119-t1x9gknd 6410 6 using use VBG cord-010119-t1x9gknd 6410 7 Gamma Gamma NNP cord-010119-t1x9gknd 6410 8 LO LO NNP cord-010119-t1x9gknd 6410 9 - - HYPH cord-010119-t1x9gknd 6410 10 ION ion NN cord-010119-t1x9gknd 6410 11 TM TM NNP cord-010119-t1x9gknd 6410 12 ( ( -LRB- cord-010119-t1x9gknd 6410 13 Immucor Immucor NNP cord-010119-t1x9gknd 6410 14 , , , cord-010119-t1x9gknd 6410 15 Inc. Inc. NNP cord-010119-t1x9gknd 6410 16 , , , cord-010119-t1x9gknd 6410 17 Norcross Norcross NNP cord-010119-t1x9gknd 6410 18 , , , cord-010119-t1x9gknd 6410 19 GA GA NNP cord-010119-t1x9gknd 6410 20 ) ) -RRB- cord-010119-t1x9gknd 6410 21 enhancement enhancement NN cord-010119-t1x9gknd 6410 22 , , , cord-010119-t1x9gknd 6410 23 elution elution NN cord-010119-t1x9gknd 6410 24 studies study NNS cord-010119-t1x9gknd 6411 1 ( ( -LRB- cord-010119-t1x9gknd 6411 2 Gamma Gamma NNP cord-010119-t1x9gknd 6411 3 ELU ELU NNP cord-010119-t1x9gknd 6411 4 - - HYPH cord-010119-t1x9gknd 6411 5 KITV KITV NNP cord-010119-t1x9gknd 6411 6 R R NNP cord-010119-t1x9gknd 6411 7 II II NNP cord-010119-t1x9gknd 6411 8 ( ( -LRB- cord-010119-t1x9gknd 6411 9 Immucor Immucor NNP cord-010119-t1x9gknd 6411 10 , , , cord-010119-t1x9gknd 6411 11 Inc. Inc. NNP cord-010119-t1x9gknd 6411 12 ) ) -RRB- cord-010119-t1x9gknd 6411 13 ) ) -RRB- cord-010119-t1x9gknd 6411 14 , , , cord-010119-t1x9gknd 6411 15 EDTA EDTA NNP cord-010119-t1x9gknd 6411 16 glycine glycine NN cord-010119-t1x9gknd 6411 17 acid acid NN cord-010119-t1x9gknd 6411 18 treatment treatment NN cord-010119-t1x9gknd 6411 19 ( ( -LRB- cord-010119-t1x9gknd 6411 20 Gamma Gamma NNP cord-010119-t1x9gknd 6411 21 EGA EGA NNP cord-010119-t1x9gknd 6411 22 TM TM NNP cord-010119-t1x9gknd 6411 23 Kit kit NN cord-010119-t1x9gknd 6411 24 ( ( -LRB- cord-010119-t1x9gknd 6411 25 Immucor Immucor NNP cord-010119-t1x9gknd 6411 26 , , , cord-010119-t1x9gknd 6411 27 Inc. Inc. NNP cord-010119-t1x9gknd 6411 28 ) ) -RRB- cord-010119-t1x9gknd 6411 29 ) ) -RRB- cord-010119-t1x9gknd 6411 30 , , , cord-010119-t1x9gknd 6411 31 allogeneic allogeneic IN cord-010119-t1x9gknd 6411 32 adsorptions adsorption NNS cord-010119-t1x9gknd 6411 33 with with IN cord-010119-t1x9gknd 6411 34 papain papain NN cord-010119-t1x9gknd 6411 35 treated treat VBN cord-010119-t1x9gknd 6411 36 intact intact JJ cord-010119-t1x9gknd 6411 37 RBCs rbc NNS cord-010119-t1x9gknd 6411 38 , , , cord-010119-t1x9gknd 6411 39 reagent reagent NN cord-010119-t1x9gknd 6411 40 and and CC cord-010119-t1x9gknd 6411 41 patient patient NN cord-010119-t1x9gknd 6411 42 - - HYPH cord-010119-t1x9gknd 6411 43 derived derive VBN cord-010119-t1x9gknd 6411 44 RBCs rbc NNS cord-010119-t1x9gknd 6411 45 and and CC cord-010119-t1x9gknd 6411 46 antisera antisera NN cord-010119-t1x9gknd 6411 47 . . . cord-010119-t1x9gknd 6412 1 Molecular molecular JJ cord-010119-t1x9gknd 6412 2 testing testing NN cord-010119-t1x9gknd 6412 3 was be VBD cord-010119-t1x9gknd 6412 4 performed perform VBN cord-010119-t1x9gknd 6412 5 with with IN cord-010119-t1x9gknd 6412 6 BioArray BioArray NNP cord-010119-t1x9gknd 6412 7 Precise Precise NNP cord-010119-t1x9gknd 6412 8 Type type NN cord-010119-t1x9gknd 6412 9 IVD IVD NNP cord-010119-t1x9gknd 6412 10 HEA HEA NNP cord-010119-t1x9gknd 6412 11 Assay Assay NNP cord-010119-t1x9gknd 6412 12 ( ( -LRB- cord-010119-t1x9gknd 6412 13 Immucor Immucor NNP cord-010119-t1x9gknd 6412 14 , , , cord-010119-t1x9gknd 6412 15 Inc. Inc. NNP cord-010119-t1x9gknd 6412 16 ) ) -RRB- cord-010119-t1x9gknd 6412 17 . . . cord-010119-t1x9gknd 6413 1 Results result NNS cord-010119-t1x9gknd 6413 2 / / SYM cord-010119-t1x9gknd 6413 3 Findings finding NNS cord-010119-t1x9gknd 6413 4 : : : cord-010119-t1x9gknd 6414 1 Molecular molecular JJ cord-010119-t1x9gknd 6414 2 testing testing NN cord-010119-t1x9gknd 6414 3 revealed reveal VBD cord-010119-t1x9gknd 6414 4 an an DT cord-010119-t1x9gknd 6414 5 RHCE*cE rhce*ce JJ cord-010119-t1x9gknd 6414 6 genotype genotype NN cord-010119-t1x9gknd 6414 7 ( ( -LRB- cord-010119-t1x9gknd 6414 8 with with IN cord-010119-t1x9gknd 6414 9 a a DT cord-010119-t1x9gknd 6414 10 C C NNP cord-010119-t1x9gknd 6414 11 - - HYPH cord-010119-t1x9gknd 6414 12 E1c1e E1c1e NNP cord-010119-t1x9gknd 6414 13 - - HYPH cord-010119-t1x9gknd 6414 14 predicted predict VBN cord-010119-t1x9gknd 6414 15 phenotype phenotype NN cord-010119-t1x9gknd 6414 16 ) ) -RRB- cord-010119-t1x9gknd 6414 17 and and CC cord-010119-t1x9gknd 6414 18 an an DT cord-010119-t1x9gknd 6414 19 otherwise otherwise RB cord-010119-t1x9gknd 6414 20 unremarkable unremarkable JJ cord-010119-t1x9gknd 6414 21 RBC RBC NNP cord-010119-t1x9gknd 6414 22 typing typing NN cord-010119-t1x9gknd 6414 23 report report NN cord-010119-t1x9gknd 6414 24 . . . cord-010119-t1x9gknd 6415 1 Serologically serologically RB cord-010119-t1x9gknd 6415 2 , , , cord-010119-t1x9gknd 6415 3 the the DT cord-010119-t1x9gknd 6415 4 antibody(ies antibody(ie NNS cord-010119-t1x9gknd 6415 5 ) ) -RRB- cord-010119-t1x9gknd 6415 6 demonstrated demonstrate VBD cord-010119-t1x9gknd 6415 7 an an DT cord-010119-t1x9gknd 6415 8 anti anti JJ cord-010119-t1x9gknd 6415 9 - - JJ cord-010119-t1x9gknd 6415 10 D d JJ cord-010119-t1x9gknd 6415 11 , , , cord-010119-t1x9gknd 6415 12 -C -C NNS cord-010119-t1x9gknd 6415 13 , , , cord-010119-t1x9gknd 6415 14 -G -G JJR cord-010119-t1x9gknd 6415 15 specificity specificity NN cord-010119-t1x9gknd 6415 16 in in IN cord-010119-t1x9gknd 6415 17 the the DT cord-010119-t1x9gknd 6415 18 serum serum NN cord-010119-t1x9gknd 6415 19 and and CC cord-010119-t1x9gknd 6415 20 eluate eluate NN cord-010119-t1x9gknd 6415 21 using use VBG cord-010119-t1x9gknd 6415 22 R r NN cord-010119-t1x9gknd 6415 23 o o NN cord-010119-t1x9gknd 6415 24 r r NN cord-010119-t1x9gknd 6415 25 , , , cord-010119-t1x9gknd 6415 26 R r NN cord-010119-t1x9gknd 6415 27 2 2 CD cord-010119-t1x9gknd 6415 28 R r NN cord-010119-t1x9gknd 6415 29 2 2 CD cord-010119-t1x9gknd 6415 30 , , , cord-010119-t1x9gknd 6415 31 r'r r'r NNP cord-010119-t1x9gknd 6415 32 , , , cord-010119-t1x9gknd 6415 33 r r NN cord-010119-t1x9gknd 6415 34 G g NN cord-010119-t1x9gknd 6415 35 r r NN cord-010119-t1x9gknd 6415 36 and and CC cord-010119-t1x9gknd 6415 37 rr rr NN cord-010119-t1x9gknd 6415 38 cells cell NNS cord-010119-t1x9gknd 6415 39 . . . cord-010119-t1x9gknd 6416 1 This this DT cord-010119-t1x9gknd 6416 2 patient patient NN cord-010119-t1x9gknd 6416 3 is be VBZ cord-010119-t1x9gknd 6416 4 predicted predict VBN cord-010119-t1x9gknd 6416 5 to to TO cord-010119-t1x9gknd 6416 6 be be VB cord-010119-t1x9gknd 6416 7 R r NN cord-010119-t1x9gknd 6416 8 2 2 CD cord-010119-t1x9gknd 6416 9 R r NN cord-010119-t1x9gknd 6416 10 2 2 CD cord-010119-t1x9gknd 6416 11 ( ( -LRB- cord-010119-t1x9gknd 6416 12 DcE dce NN cord-010119-t1x9gknd 6416 13 / / SYM cord-010119-t1x9gknd 6416 14 DcE DcE NNP cord-010119-t1x9gknd 6416 15 ) ) -RRB- cord-010119-t1x9gknd 6416 16 therefore therefore RB cord-010119-t1x9gknd 6416 17 , , , cord-010119-t1x9gknd 6416 18 anti anti NNP cord-010119-t1x9gknd 6416 19 - - NN cord-010119-t1x9gknd 6416 20 C C NNP cord-010119-t1x9gknd 6416 21 is be VBZ cord-010119-t1x9gknd 6416 22 possible possible JJ cord-010119-t1x9gknd 6416 23 but but CC cord-010119-t1x9gknd 6416 24 an an DT cord-010119-t1x9gknd 6416 25 allogeneic allogeneic JJ cord-010119-t1x9gknd 6416 26 anti anti JJ cord-010119-t1x9gknd 6416 27 - - JJ cord-010119-t1x9gknd 6416 28 D d JJ cord-010119-t1x9gknd 6416 29 or or CC cord-010119-t1x9gknd 6416 30 -G -G JJR cord-010119-t1x9gknd 6416 31 is be VBZ cord-010119-t1x9gknd 6416 32 exceptionally exceptionally RB cord-010119-t1x9gknd 6416 33 unlikely unlikely JJ cord-010119-t1x9gknd 6416 34 . . . cord-010119-t1x9gknd 6417 1 Allogenic allogenic JJ cord-010119-t1x9gknd 6417 2 adsorptions adsorption NNS cord-010119-t1x9gknd 6417 3 using use VBG cord-010119-t1x9gknd 6417 4 papain papain NN cord-010119-t1x9gknd 6417 5 treated treat VBN cord-010119-t1x9gknd 6417 6 R r NN cord-010119-t1x9gknd 6417 7 o o NN cord-010119-t1x9gknd 6417 8 r r NN cord-010119-t1x9gknd 6417 9 and and CC cord-010119-t1x9gknd 6417 10 r'r r'r NNP cord-010119-t1x9gknd 6417 11 cells cell NNS cord-010119-t1x9gknd 6417 12 excluded exclude VBN cord-010119-t1x9gknd 6417 13 anti anti JJ cord-010119-t1x9gknd 6417 14 - - JJ cord-010119-t1x9gknd 6417 15 C c JJ cord-010119-t1x9gknd 6417 16 and and CC cord-010119-t1x9gknd 6417 17 anti anti JJ cord-010119-t1x9gknd 6417 18 - - JJ cord-010119-t1x9gknd 6417 19 D d JJ cord-010119-t1x9gknd 6417 20 , , , cord-010119-t1x9gknd 6417 21 leaving leave VBG cord-010119-t1x9gknd 6417 22 anti anti JJ cord-010119-t1x9gknd 6417 23 - - JJ cord-010119-t1x9gknd 6417 24 G g NN cord-010119-t1x9gknd 6417 25 as as IN cord-010119-t1x9gknd 6417 26 the the DT cord-010119-t1x9gknd 6417 27 only only JJ cord-010119-t1x9gknd 6417 28 explanation explanation NN cord-010119-t1x9gknd 6417 29 of of IN cord-010119-t1x9gknd 6417 30 the the DT cord-010119-t1x9gknd 6417 31 initial initial JJ cord-010119-t1x9gknd 6417 32 findings finding NNS cord-010119-t1x9gknd 6417 33 . . . cord-010119-t1x9gknd 6418 1 Reactivity reactivity NN cord-010119-t1x9gknd 6418 2 with with IN cord-010119-t1x9gknd 6418 3 the the DT cord-010119-t1x9gknd 6418 4 patient patient NN cord-010119-t1x9gknd 6418 5 's 's POS cord-010119-t1x9gknd 6418 6 EGA EGA NNP cord-010119-t1x9gknd 6418 7 treated treat VBN cord-010119-t1x9gknd 6418 8 ( ( -LRB- cord-010119-t1x9gknd 6418 9 DAT DAT NNP cord-010119-t1x9gknd 6418 10 negative negative JJ cord-010119-t1x9gknd 6418 11 ) ) -RRB- cord-010119-t1x9gknd 6418 12 cells cell NNS cord-010119-t1x9gknd 6418 13 against against IN cord-010119-t1x9gknd 6418 14 the the DT cord-010119-t1x9gknd 6418 15 " " `` cord-010119-t1x9gknd 6418 16 neat neat JJ cord-010119-t1x9gknd 6418 17 " " '' cord-010119-t1x9gknd 6418 18 serum serum NN cord-010119-t1x9gknd 6418 19 , , , cord-010119-t1x9gknd 6418 20 eluate eluate NN cord-010119-t1x9gknd 6418 21 and and CC cord-010119-t1x9gknd 6419 1 anti anti JJ cord-010119-t1x9gknd 6419 2 - - JJ cord-010119-t1x9gknd 6419 3 G g JJ cord-010119-t1x9gknd 6419 4 antisera antisera NN cord-010119-t1x9gknd 6419 5 confirmed confirm VBD cord-010119-t1x9gknd 6419 6 auto auto NN cord-010119-t1x9gknd 6419 7 anti anti NNP cord-010119-t1x9gknd 6419 8 - - NNP cord-010119-t1x9gknd 6419 9 G. G. NNP cord-010119-t1x9gknd 6419 10 Conclusion conclusion NN cord-010119-t1x9gknd 6419 11 : : : cord-010119-t1x9gknd 6420 1 Warm warm JJ cord-010119-t1x9gknd 6420 2 autoantibodies autoantibody NNS cord-010119-t1x9gknd 6420 3 are be VBP cord-010119-t1x9gknd 6420 4 common common JJ cord-010119-t1x9gknd 6420 5 findings finding NNS cord-010119-t1x9gknd 6420 6 and and CC cord-010119-t1x9gknd 6420 7 often often RB cord-010119-t1x9gknd 6420 8 have have VBP cord-010119-t1x9gknd 6420 9 an an DT cord-010119-t1x9gknd 6420 10 Rh Rh NNP cord-010119-t1x9gknd 6420 11 specificity specificity NN cord-010119-t1x9gknd 6420 12 ; ; : cord-010119-t1x9gknd 6420 13 however however RB cord-010119-t1x9gknd 6420 14 , , , cord-010119-t1x9gknd 6420 15 these these DT cord-010119-t1x9gknd 6420 16 antibodies antibody NNS cord-010119-t1x9gknd 6420 17 usually usually RB cord-010119-t1x9gknd 6420 18 demonstrate demonstrate VBP cord-010119-t1x9gknd 6420 19 a a DT cord-010119-t1x9gknd 6420 20 broad broad JJ cord-010119-t1x9gknd 6420 21 but but CC cord-010119-t1x9gknd 6420 22 weaker weak JJR cord-010119-t1x9gknd 6420 23 specificity specificity NN cord-010119-t1x9gknd 6420 24 in in IN cord-010119-t1x9gknd 6420 25 the the DT cord-010119-t1x9gknd 6420 26 eluate eluate NN cord-010119-t1x9gknd 6420 27 or or CC cord-010119-t1x9gknd 6420 28 in in IN cord-010119-t1x9gknd 6420 29 the the DT cord-010119-t1x9gknd 6420 30 serum serum NN cord-010119-t1x9gknd 6420 31 when when WRB cord-010119-t1x9gknd 6420 32 enhancements enhancement NNS cord-010119-t1x9gknd 6420 33 are be VBP cord-010119-t1x9gknd 6420 34 used use VBN cord-010119-t1x9gknd 6420 35 . . . cord-010119-t1x9gknd 6421 1 This this DT cord-010119-t1x9gknd 6421 2 anti anti JJ cord-010119-t1x9gknd 6421 3 - - JJ cord-010119-t1x9gknd 6421 4 G G NNP cord-010119-t1x9gknd 6421 5 had have VBD cord-010119-t1x9gknd 6421 6 no no DT cord-010119-t1x9gknd 6421 7 reactivity reactivity NN cord-010119-t1x9gknd 6421 8 with with IN cord-010119-t1x9gknd 6421 9 G g NN cord-010119-t1x9gknd 6421 10 - - HYPH cord-010119-t1x9gknd 6421 11 cells cell NNS cord-010119-t1x9gknd 6421 12 . . . cord-010119-t1x9gknd 6422 1 The the DT cord-010119-t1x9gknd 6422 2 differentiation differentiation NN cord-010119-t1x9gknd 6422 3 of of IN cord-010119-t1x9gknd 6422 4 anti anti JJ cord-010119-t1x9gknd 6422 5 - - JJ cord-010119-t1x9gknd 6422 6 G g NN cord-010119-t1x9gknd 6422 7 from from IN cord-010119-t1x9gknd 6422 8 anti anti JJ cord-010119-t1x9gknd 6422 9 - - JJ cord-010119-t1x9gknd 6422 10 D d JJ cord-010119-t1x9gknd 6422 11 and and CC cord-010119-t1x9gknd 6422 12 anti anti JJ cord-010119-t1x9gknd 6422 13 - - NN cord-010119-t1x9gknd 6422 14 C C NNP cord-010119-t1x9gknd 6422 15 is be VBZ cord-010119-t1x9gknd 6422 16 generally generally RB cord-010119-t1x9gknd 6422 17 academic academic JJ cord-010119-t1x9gknd 6422 18 as as IN cord-010119-t1x9gknd 6422 19 transfusion transfusion NN cord-010119-t1x9gknd 6422 20 recommendations recommendation NNS cord-010119-t1x9gknd 6422 21 are be VBP cord-010119-t1x9gknd 6422 22 the the DT cord-010119-t1x9gknd 6422 23 same same JJ cord-010119-t1x9gknd 6422 24 : : : cord-010119-t1x9gknd 6422 25 provide provide VB cord-010119-t1x9gknd 6422 26 RhD- RhD- NNP cord-010119-t1x9gknd 6422 27 , , , cord-010119-t1x9gknd 6422 28 C c NN cord-010119-t1x9gknd 6422 29 - - HYPH cord-010119-t1x9gknd 6422 30 units unit NNS cord-010119-t1x9gknd 6422 31 . . . cord-010119-t1x9gknd 6423 1 It -PRON- PRP cord-010119-t1x9gknd 6423 2 is be VBZ cord-010119-t1x9gknd 6423 3 relevant relevant JJ cord-010119-t1x9gknd 6423 4 and and CC cord-010119-t1x9gknd 6423 5 clinically clinically RB cord-010119-t1x9gknd 6423 6 important important JJ cord-010119-t1x9gknd 6423 7 to to TO cord-010119-t1x9gknd 6423 8 determine determine VB cord-010119-t1x9gknd 6423 9 the the DT cord-010119-t1x9gknd 6423 10 presence presence NN cord-010119-t1x9gknd 6423 11 or or CC cord-010119-t1x9gknd 6423 12 absence absence NN cord-010119-t1x9gknd 6423 13 of of IN cord-010119-t1x9gknd 6423 14 anti anti JJ cord-010119-t1x9gknd 6423 15 - - JJ cord-010119-t1x9gknd 6423 16 D d JJ cord-010119-t1x9gknd 6423 17 in in IN cord-010119-t1x9gknd 6423 18 RhD rhd NN cord-010119-t1x9gknd 6423 19 negative negative JJ cord-010119-t1x9gknd 6423 20 women woman NNS cord-010119-t1x9gknd 6423 21 of of IN cord-010119-t1x9gknd 6423 22 childbearing childbeare VBG cord-010119-t1x9gknd 6423 23 age age NN cord-010119-t1x9gknd 6423 24 who who WP cord-010119-t1x9gknd 6423 25 present present VBP cord-010119-t1x9gknd 6423 26 with with IN cord-010119-t1x9gknd 6423 27 an an DT cord-010119-t1x9gknd 6423 28 anti anti JJ cord-010119-t1x9gknd 6423 29 - - JJ cord-010119-t1x9gknd 6423 30 G g JJ cord-010119-t1x9gknd 6423 31 specificity specificity NN cord-010119-t1x9gknd 6423 32 . . . cord-010119-t1x9gknd 6424 1 If if IN cord-010119-t1x9gknd 6424 2 anti anti JJ cord-010119-t1x9gknd 6424 3 - - JJ cord-010119-t1x9gknd 6424 4 D d JJ cord-010119-t1x9gknd 6424 5 is be VBZ cord-010119-t1x9gknd 6424 6 135A 135a CD cord-010119-t1x9gknd 6424 7 TRANSFUSION transfusion NN cord-010119-t1x9gknd 6424 8 2017 2017 CD cord-010119-t1x9gknd 6424 9 Vol Vol NNP cord-010119-t1x9gknd 6424 10 . . . cord-010119-t1x9gknd 6425 1 57 57 CD cord-010119-t1x9gknd 6425 2 Supplement Supplement NNP cord-010119-t1x9gknd 6425 3 S3 S3 NNP cord-010119-t1x9gknd 6425 4 excluded exclude VBD cord-010119-t1x9gknd 6425 5 these these DT cord-010119-t1x9gknd 6425 6 women woman NNS cord-010119-t1x9gknd 6425 7 should should MD cord-010119-t1x9gknd 6425 8 receive receive VB cord-010119-t1x9gknd 6425 9 RhIG rhig NN cord-010119-t1x9gknd 6425 10 as as IN cord-010119-t1x9gknd 6425 11 part part NN cord-010119-t1x9gknd 6425 12 of of IN cord-010119-t1x9gknd 6425 13 their -PRON- PRP$ cord-010119-t1x9gknd 6425 14 prenatal prenatal JJ cord-010119-t1x9gknd 6425 15 care care NN cord-010119-t1x9gknd 6425 16 . . . cord-010119-t1x9gknd 6426 1 In in IN cord-010119-t1x9gknd 6426 2 this this DT cord-010119-t1x9gknd 6426 3 case case NN cord-010119-t1x9gknd 6426 4 differentiating differentiate VBG cord-010119-t1x9gknd 6426 5 anti anti JJ cord-010119-t1x9gknd 6426 6 - - JJ cord-010119-t1x9gknd 6426 7 D d JJ cord-010119-t1x9gknd 6426 8 , , , cord-010119-t1x9gknd 6426 9 -C -C VBZ cord-010119-t1x9gknd 6426 10 from from IN cord-010119-t1x9gknd 6426 11 an an DT cord-010119-t1x9gknd 6426 12 auto auto NN cord-010119-t1x9gknd 6426 13 anti anti NN cord-010119-t1x9gknd 6426 14 - - NN cord-010119-t1x9gknd 6426 15 G G NNP cord-010119-t1x9gknd 6426 16 was be VBD cord-010119-t1x9gknd 6426 17 necessary necessary JJ cord-010119-t1x9gknd 6426 18 to to TO cord-010119-t1x9gknd 6426 19 provide provide VB cord-010119-t1x9gknd 6426 20 transfusion transfusion NN cord-010119-t1x9gknd 6426 21 recommendations recommendation NNS cord-010119-t1x9gknd 6426 22 . . . cord-010119-t1x9gknd 6427 1 Providing provide VBG cord-010119-t1x9gknd 6427 2 RhD rhd NN cord-010119-t1x9gknd 6427 3 - - : cord-010119-t1x9gknd 6427 4 and and CC cord-010119-t1x9gknd 6427 5 C C NNP cord-010119-t1x9gknd 6427 6 - - HYPH cord-010119-t1x9gknd 6427 7 units unit NNS cord-010119-t1x9gknd 6427 8 to to TO cord-010119-t1x9gknd 6427 9 give give VB cord-010119-t1x9gknd 6427 10 serologically serologically RB cord-010119-t1x9gknd 6427 11 compatible compatible JJ cord-010119-t1x9gknd 6427 12 RBCs rbc NNS cord-010119-t1x9gknd 6427 13 could could MD cord-010119-t1x9gknd 6427 14 result result VB cord-010119-t1x9gknd 6427 15 in in IN cord-010119-t1x9gknd 6427 16 formation formation NN cord-010119-t1x9gknd 6427 17 of of IN cord-010119-t1x9gknd 6427 18 an an DT cord-010119-t1x9gknd 6427 19 allogeneic allogeneic JJ cord-010119-t1x9gknd 6427 20 anti anti NN cord-010119-t1x9gknd 6427 21 - - NN cord-010119-t1x9gknd 6427 22 e e NN cord-010119-t1x9gknd 6427 23 . . . cord-010119-t1x9gknd 6428 1 Automated automated JJ cord-010119-t1x9gknd 6428 2 Eluates Eluates NNPS cord-010119-t1x9gknd 6428 3 : : : cord-010119-t1x9gknd 6429 1 Comparison comparison NN cord-010119-t1x9gknd 6429 2 of of IN cord-010119-t1x9gknd 6429 3 Solid Solid NNP cord-010119-t1x9gknd 6429 4 - - HYPH cord-010119-t1x9gknd 6429 5 Phase Phase NNP cord-010119-t1x9gknd 6429 6 Red red JJ cord-010119-t1x9gknd 6429 7 Cell cell NN cord-010119-t1x9gknd 6429 8 Adherence Adherence NNP cord-010119-t1x9gknd 6429 9 and and CC cord-010119-t1x9gknd 6429 10 Gel Gel NNP cord-010119-t1x9gknd 6429 11 Automated Automated NNP cord-010119-t1x9gknd 6429 12 Eluate Eluate NNP cord-010119-t1x9gknd 6429 13 Testing Testing NNP cord-010119-t1x9gknd 6429 14 Jayanna Jayanna NNP cord-010119-t1x9gknd 6429 15 Slayten Slayten NNP cord-010119-t1x9gknd 6429 16 * * NFP cord-010119-t1x9gknd 6429 17 1 1 CD cord-010119-t1x9gknd 6429 18 , , , cord-010119-t1x9gknd 6429 19 Christa Christa NNP cord-010119-t1x9gknd 6429 20 Voliva Voliva NNP cord-010119-t1x9gknd 6429 21 1 1 CD cord-010119-t1x9gknd 6429 22 , , , cord-010119-t1x9gknd 6429 23 Kathy Kathy NNP cord-010119-t1x9gknd 6429 24 Fletcher Fletcher NNP cord-010119-t1x9gknd 6429 25 1 1 CD cord-010119-t1x9gknd 6429 26 , , , cord-010119-t1x9gknd 6429 27 Heather Heather NNP cord-010119-t1x9gknd 6429 28 Vaught Vaught NNP cord-010119-t1x9gknd 6429 29 2 2 CD cord-010119-t1x9gknd 6429 30 and and CC cord-010119-t1x9gknd 6429 31 Tracie Tracie NNP cord-010119-t1x9gknd 6429 32 Ingle Ingle NNP cord-010119-t1x9gknd 6429 33 1 1 CD cord-010119-t1x9gknd 6429 34 . . . cord-010119-t1x9gknd 6430 1 1 1 LS cord-010119-t1x9gknd 6431 1 Indiana Indiana NNP cord-010119-t1x9gknd 6431 2 University University NNP cord-010119-t1x9gknd 6431 3 Health Health NNP cord-010119-t1x9gknd 6431 4 , , , cord-010119-t1x9gknd 6431 5 2 2 CD cord-010119-t1x9gknd 6431 6 Indiana Indiana NNP cord-010119-t1x9gknd 6431 7 University University NNP cord-010119-t1x9gknd 6431 8 Health Health NNP cord-010119-t1x9gknd 6431 9 ( ( -LRB- cord-010119-t1x9gknd 6431 10 IU IU NNP cord-010119-t1x9gknd 6431 11 Health Health NNP cord-010119-t1x9gknd 6431 12 ) ) -RRB- cord-010119-t1x9gknd 6432 1 Background Background NNP cord-010119-t1x9gknd 6432 2 / / SYM cord-010119-t1x9gknd 6432 3 Case Case NNP cord-010119-t1x9gknd 6432 4 Studies Studies NNPS cord-010119-t1x9gknd 6432 5 : : : cord-010119-t1x9gknd 6432 6 Acid acid JJ cord-010119-t1x9gknd 6432 7 Eluates Eluates NNPS cord-010119-t1x9gknd 6432 8 ( ( -LRB- cord-010119-t1x9gknd 6432 9 ELU ELU NNP cord-010119-t1x9gknd 6432 10 Kit Kit NNP cord-010119-t1x9gknd 6432 11 II II NNP cord-010119-t1x9gknd 6432 12 . . . cord-010119-t1x9gknd 6433 1 Immucor Immucor NNP cord-010119-t1x9gknd 6433 2 . . . cord-010119-t1x9gknd 6434 1 Norcross Norcross NNP cord-010119-t1x9gknd 6434 2 , , , cord-010119-t1x9gknd 6434 3 GA GA NNP cord-010119-t1x9gknd 6434 4 ) ) -RRB- cord-010119-t1x9gknd 6434 5 are be VBP cord-010119-t1x9gknd 6434 6 to to TO cord-010119-t1x9gknd 6434 7 be be VB cord-010119-t1x9gknd 6434 8 tested test VBN cord-010119-t1x9gknd 6434 9 via via IN cord-010119-t1x9gknd 6434 10 tube tube NN cord-010119-t1x9gknd 6434 11 IAT IAT NNP cord-010119-t1x9gknd 6434 12 method method NN cord-010119-t1x9gknd 6434 13 in in IN cord-010119-t1x9gknd 6434 14 parallel parallel NN cord-010119-t1x9gknd 6434 15 with with IN cord-010119-t1x9gknd 6434 16 the the DT cord-010119-t1x9gknd 6434 17 recovered recover VBN cord-010119-t1x9gknd 6434 18 last last JJ cord-010119-t1x9gknd 6434 19 wash wash NN cord-010119-t1x9gknd 6434 20 per per IN cord-010119-t1x9gknd 6434 21 the the DT cord-010119-t1x9gknd 6434 22 manufacturer manufacturer NN cord-010119-t1x9gknd 6434 23 's 's POS cord-010119-t1x9gknd 6434 24 package package NN cord-010119-t1x9gknd 6434 25 insert insert NN cord-010119-t1x9gknd 6434 26 . . . cord-010119-t1x9gknd 6435 1 Finck Finck NNP cord-010119-t1x9gknd 6435 2 et et NNP cord-010119-t1x9gknd 6435 3 al al NNP cord-010119-t1x9gknd 6435 4 ( ( -LRB- cord-010119-t1x9gknd 6435 5 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 6435 6 2011 2011 CD cord-010119-t1x9gknd 6436 1 ; ; : cord-010119-t1x9gknd 6436 2 27:1 27:1 CD cord-010119-t1x9gknd 6436 3 - - SYM cord-010119-t1x9gknd 6436 4 5 5 CD cord-010119-t1x9gknd 6436 5 ) ) -RRB- cord-010119-t1x9gknd 6436 6 demonstrated demonstrate VBD cord-010119-t1x9gknd 6436 7 acid acid JJ cord-010119-t1x9gknd 6436 8 eluates eluate NNS cord-010119-t1x9gknd 6436 9 may may MD cord-010119-t1x9gknd 6436 10 be be VB cord-010119-t1x9gknd 6436 11 tested test VBN cord-010119-t1x9gknd 6436 12 in in IN cord-010119-t1x9gknd 6436 13 other other JJ cord-010119-t1x9gknd 6436 14 platforms platform NNS cord-010119-t1x9gknd 6436 15 such such JJ cord-010119-t1x9gknd 6436 16 as as IN cord-010119-t1x9gknd 6436 17 manual manual NNP cord-010119-t1x9gknd 6436 18 gel gel NN cord-010119-t1x9gknd 6436 19 microcolumn microcolumn NN cord-010119-t1x9gknd 6436 20 assay assay NNP cord-010119-t1x9gknd 6436 21 ( ( -LRB- cord-010119-t1x9gknd 6436 22 ID ID NNP cord-010119-t1x9gknd 6436 23 - - HYPH cord-010119-t1x9gknd 6436 24 MTS.IgG MTS.IgG NNP cord-010119-t1x9gknd 6436 25 Card Card NNP cord-010119-t1x9gknd 6436 26 . . . cord-010119-t1x9gknd 6437 1 Ortho Ortho NNP cord-010119-t1x9gknd 6437 2 Clinical Clinical NNP cord-010119-t1x9gknd 6437 3 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 6437 4 . . . cord-010119-t1x9gknd 6438 1 Raritan Raritan NNP cord-010119-t1x9gknd 6438 2 , , , cord-010119-t1x9gknd 6438 3 NJ NJ NNP cord-010119-t1x9gknd 6438 4 ) ) -RRB- cord-010119-t1x9gknd 6438 5 and and CC cord-010119-t1x9gknd 6438 6 automated automate VBN cord-010119-t1x9gknd 6438 7 solid solid JJ cord-010119-t1x9gknd 6438 8 - - HYPH cord-010119-t1x9gknd 6438 9 phase phase NN cord-010119-t1x9gknd 6438 10 red red JJ cord-010119-t1x9gknd 6438 11 cell cell NN cord-010119-t1x9gknd 6438 12 adherence adherence NN cord-010119-t1x9gknd 6438 13 systems system NNS cord-010119-t1x9gknd 6438 14 ( ( -LRB- cord-010119-t1x9gknd 6438 15 Echo echo NN cord-010119-t1x9gknd 6438 16 . . . cord-010119-t1x9gknd 6439 1 Immucor Immucor NNP cord-010119-t1x9gknd 6439 2 . . . cord-010119-t1x9gknd 6440 1 Norcross Norcross NNP cord-010119-t1x9gknd 6440 2 , , , cord-010119-t1x9gknd 6440 3 GA GA NNP cord-010119-t1x9gknd 6440 4 ) ) -RRB- cord-010119-t1x9gknd 6440 5 . . . cord-010119-t1x9gknd 6441 1 Our -PRON- PRP$ cord-010119-t1x9gknd 6441 2 study study NN cord-010119-t1x9gknd 6441 3 looked look VBD cord-010119-t1x9gknd 6441 4 to to TO cord-010119-t1x9gknd 6441 5 compare compare VB cord-010119-t1x9gknd 6441 6 the the DT cord-010119-t1x9gknd 6441 7 use use NN cord-010119-t1x9gknd 6441 8 of of IN cord-010119-t1x9gknd 6441 9 the the DT cord-010119-t1x9gknd 6441 10 automated automate VBN cord-010119-t1x9gknd 6441 11 gel gel NN cord-010119-t1x9gknd 6441 12 microcolumn microcolumn NN cord-010119-t1x9gknd 6441 13 analyzer analyzer NN cord-010119-t1x9gknd 6441 14 ( ( -LRB- cord-010119-t1x9gknd 6441 15 VISION vision NN cord-010119-t1x9gknd 6441 16 , , , cord-010119-t1x9gknd 6441 17 Ortho Ortho NNP cord-010119-t1x9gknd 6441 18 Clinical Clinical NNP cord-010119-t1x9gknd 6441 19 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 6441 20 . . . cord-010119-t1x9gknd 6442 1 Raritan Raritan NNP cord-010119-t1x9gknd 6442 2 , , , cord-010119-t1x9gknd 6442 3 NJ NJ NNP cord-010119-t1x9gknd 6442 4 ) ) -RRB- cord-010119-t1x9gknd 6442 5 to to IN cord-010119-t1x9gknd 6442 6 the the DT cord-010119-t1x9gknd 6442 7 solid solid JJ cord-010119-t1x9gknd 6442 8 - - HYPH cord-010119-t1x9gknd 6442 9 phase phase NN cord-010119-t1x9gknd 6442 10 red red JJ cord-010119-t1x9gknd 6442 11 cell cell NN cord-010119-t1x9gknd 6442 12 adherence adherence NN cord-010119-t1x9gknd 6442 13 analyzer analyzer NN cord-010119-t1x9gknd 6442 14 ( ( -LRB- cord-010119-t1x9gknd 6442 15 ECHO echo NN cord-010119-t1x9gknd 6442 16 , , , cord-010119-t1x9gknd 6442 17 Immucor Immucor NNP cord-010119-t1x9gknd 6442 18 . . . cord-010119-t1x9gknd 6443 1 Norcross Norcross NNP cord-010119-t1x9gknd 6443 2 , , , cord-010119-t1x9gknd 6443 3 GA GA NNP cord-010119-t1x9gknd 6443 4 ) ) -RRB- cord-010119-t1x9gknd 6443 5 for for IN cord-010119-t1x9gknd 6443 6 the the DT cord-010119-t1x9gknd 6443 7 testing testing NN cord-010119-t1x9gknd 6443 8 of of IN cord-010119-t1x9gknd 6443 9 acid acid JJ cord-010119-t1x9gknd 6443 10 eluates eluate NNS cord-010119-t1x9gknd 6443 11 in in IN cord-010119-t1x9gknd 6443 12 a a DT cord-010119-t1x9gknd 6443 13 regional regional JJ cord-010119-t1x9gknd 6443 14 Midwestern midwestern JJ cord-010119-t1x9gknd 6443 15 transfusion transfusion NN cord-010119-t1x9gknd 6443 16 service service NN cord-010119-t1x9gknd 6443 17 . . . cord-010119-t1x9gknd 6444 1 Study Study NNP cord-010119-t1x9gknd 6444 2 Design Design NNP cord-010119-t1x9gknd 6444 3 / / SYM cord-010119-t1x9gknd 6444 4 Methods method NNS cord-010119-t1x9gknd 6444 5 : : : cord-010119-t1x9gknd 6445 1 Twenty twenty CD cord-010119-t1x9gknd 6445 2 patient patient NN cord-010119-t1x9gknd 6445 3 samples sample NNS cord-010119-t1x9gknd 6445 4 , , , cord-010119-t1x9gknd 6445 5 less less JJR cord-010119-t1x9gknd 6445 6 than than IN cord-010119-t1x9gknd 6445 7 7 7 CD cord-010119-t1x9gknd 6445 8 days day NNS cord-010119-t1x9gknd 6445 9 from from IN cord-010119-t1x9gknd 6445 10 collection collection NN cord-010119-t1x9gknd 6445 11 and and CC cord-010119-t1x9gknd 6445 12 drawn draw VBN cord-010119-t1x9gknd 6445 13 in in IN cord-010119-t1x9gknd 6445 14 EDTA EDTA NNP cord-010119-t1x9gknd 6445 15 , , , cord-010119-t1x9gknd 6445 16 were be VBD cord-010119-t1x9gknd 6445 17 used use VBN cord-010119-t1x9gknd 6445 18 to to TO cord-010119-t1x9gknd 6445 19 prepare prepare VB cord-010119-t1x9gknd 6445 20 acid acid JJ cord-010119-t1x9gknd 6445 21 eluates eluate NNS cord-010119-t1x9gknd 6445 22 ( ( -LRB- cord-010119-t1x9gknd 6445 23 Elu Elu NNP cord-010119-t1x9gknd 6445 24 - - HYPH cord-010119-t1x9gknd 6445 25 Kit Kit NNP cord-010119-t1x9gknd 6445 26 II II NNP cord-010119-t1x9gknd 6445 27 . . . cord-010119-t1x9gknd 6446 1 Immucor Immucor NNP cord-010119-t1x9gknd 6446 2 . . . cord-010119-t1x9gknd 6447 1 Norcross Norcross NNP cord-010119-t1x9gknd 6447 2 , , , cord-010119-t1x9gknd 6447 3 GA GA NNP cord-010119-t1x9gknd 6447 4 ) ) -RRB- cord-010119-t1x9gknd 6447 5 while while IN cord-010119-t1x9gknd 6447 6 retaining retain VBG cord-010119-t1x9gknd 6447 7 the the DT cord-010119-t1x9gknd 6447 8 last last JJ cord-010119-t1x9gknd 6447 9 wash wash NN cord-010119-t1x9gknd 6447 10 to to TO cord-010119-t1x9gknd 6447 11 be be VB cord-010119-t1x9gknd 6447 12 tested test VBN cord-010119-t1x9gknd 6447 13 in in IN cord-010119-t1x9gknd 6447 14 parallel parallel NN cord-010119-t1x9gknd 6447 15 . . . cord-010119-t1x9gknd 6448 1 Two two CD cord-010119-t1x9gknd 6448 2 samples sample NNS cord-010119-t1x9gknd 6448 3 were be VBD cord-010119-t1x9gknd 6448 4 > > NNS cord-010119-t1x9gknd 6448 5 21 21 CD cord-010119-t1x9gknd 6448 6 DAT DAT NNP cord-010119-t1x9gknd 6448 7 positive positive JJ cord-010119-t1x9gknd 6448 8 , , , cord-010119-t1x9gknd 6448 9 2 2 CD cord-010119-t1x9gknd 6448 10 were be VBD cord-010119-t1x9gknd 6448 11 weakly weakly RB cord-010119-t1x9gknd 6448 12 DAT DAT NNP cord-010119-t1x9gknd 6448 13 positive positive JJ cord-010119-t1x9gknd 6448 14 and and CC cord-010119-t1x9gknd 6448 15 16 16 CD cord-010119-t1x9gknd 6448 16 were be VBD cord-010119-t1x9gknd 6448 17 DAT DAT NNP cord-010119-t1x9gknd 6448 18 negative negative JJ cord-010119-t1x9gknd 6448 19 . . . cord-010119-t1x9gknd 6449 1 The the DT cord-010119-t1x9gknd 6449 2 prepared prepared JJ cord-010119-t1x9gknd 6449 3 eluates eluate NNS cord-010119-t1x9gknd 6449 4 were be VBD cord-010119-t1x9gknd 6449 5 observed observe VBN cord-010119-t1x9gknd 6449 6 for for IN cord-010119-t1x9gknd 6449 7 color color NN cord-010119-t1x9gknd 6449 8 ( ( -LRB- cord-010119-t1x9gknd 6449 9 bluegreen bluegreen NNP cord-010119-t1x9gknd 6449 10 / / SYM cord-010119-t1x9gknd 6449 11 BG BG NNP cord-010119-t1x9gknd 6449 12 , , , cord-010119-t1x9gknd 6449 13 blue blue JJ cord-010119-t1x9gknd 6449 14 - - HYPH cord-010119-t1x9gknd 6449 15 brown brown JJ cord-010119-t1x9gknd 6449 16 / / SYM cord-010119-t1x9gknd 6449 17 BB bb NN cord-010119-t1x9gknd 6449 18 , , , cord-010119-t1x9gknd 6449 19 blue blue JJ cord-010119-t1x9gknd 6449 20 - - HYPH cord-010119-t1x9gknd 6449 21 purple purple NN cord-010119-t1x9gknd 6449 22 / / SYM cord-010119-t1x9gknd 6449 23 BP BP NNP cord-010119-t1x9gknd 6449 24 ) ) -RRB- cord-010119-t1x9gknd 6449 25 , , , cord-010119-t1x9gknd 6449 26 and and CC cord-010119-t1x9gknd 6449 27 the the DT cord-010119-t1x9gknd 6449 28 pH pH NNP cord-010119-t1x9gknd 6449 29 was be VBD cord-010119-t1x9gknd 6449 30 documented document VBN cord-010119-t1x9gknd 6449 31 for for IN cord-010119-t1x9gknd 6449 32 the the DT cord-010119-t1x9gknd 6449 33 prepared prepared JJ cord-010119-t1x9gknd 6449 34 eluate eluate NN cord-010119-t1x9gknd 6449 35 ( ( -LRB- cord-010119-t1x9gknd 6449 36 Whatman Whatman NNP cord-010119-t1x9gknd 6449 37 6.0 6.0 CD cord-010119-t1x9gknd 6449 38 - - HYPH cord-010119-t1x9gknd 6449 39 8.1pH. 8.1ph. CD cord-010119-t1x9gknd 6449 40 Whatman Whatman NNP cord-010119-t1x9gknd 6449 41 International International NNP cord-010119-t1x9gknd 6449 42 . . . cord-010119-t1x9gknd 6450 1 Maidstone Maidstone NNP cord-010119-t1x9gknd 6450 2 , , , cord-010119-t1x9gknd 6450 3 England England NNP cord-010119-t1x9gknd 6450 4 ) ) -RRB- cord-010119-t1x9gknd 6450 5 . . . cord-010119-t1x9gknd 6451 1 The the DT cord-010119-t1x9gknd 6451 2 prepared prepared JJ cord-010119-t1x9gknd 6451 3 eluates eluate NNS cord-010119-t1x9gknd 6451 4 and and CC cord-010119-t1x9gknd 6451 5 last last JJ cord-010119-t1x9gknd 6451 6 washes wash NNS cord-010119-t1x9gknd 6451 7 were be VBD cord-010119-t1x9gknd 6451 8 tested test VBN cord-010119-t1x9gknd 6451 9 on on IN cord-010119-t1x9gknd 6451 10 the the DT cord-010119-t1x9gknd 6451 11 VISION vision NN cord-010119-t1x9gknd 6451 12 and and CC cord-010119-t1x9gknd 6451 13 ECHO echo NN cord-010119-t1x9gknd 6451 14 against against IN cord-010119-t1x9gknd 6451 15 an an DT cord-010119-t1x9gknd 6451 16 antibody antibody NN cord-010119-t1x9gknd 6451 17 screen screen NN cord-010119-t1x9gknd 6451 18 . . . cord-010119-t1x9gknd 6452 1 If if IN cord-010119-t1x9gknd 6452 2 the the DT cord-010119-t1x9gknd 6452 3 antibody antibody NN cord-010119-t1x9gknd 6452 4 screen screen NN cord-010119-t1x9gknd 6452 5 was be VBD cord-010119-t1x9gknd 6452 6 positive positive JJ cord-010119-t1x9gknd 6452 7 , , , cord-010119-t1x9gknd 6452 8 the the DT cord-010119-t1x9gknd 6452 9 sample sample NN cord-010119-t1x9gknd 6452 10 was be VBD cord-010119-t1x9gknd 6452 11 tested test VBN cord-010119-t1x9gknd 6452 12 against against IN cord-010119-t1x9gknd 6452 13 an an DT cord-010119-t1x9gknd 6452 14 antibody antibody NN cord-010119-t1x9gknd 6452 15 panel panel NN cord-010119-t1x9gknd 6452 16 to to TO cord-010119-t1x9gknd 6452 17 determine determine VB cord-010119-t1x9gknd 6452 18 specificity specificity NN cord-010119-t1x9gknd 6452 19 / / SYM cord-010119-t1x9gknd 6452 20 pan pan NN cord-010119-t1x9gknd 6452 21 - - NN cord-010119-t1x9gknd 6452 22 reactivity reactivity NN cord-010119-t1x9gknd 6452 23 . . . cord-010119-t1x9gknd 6453 1 Prior prior RB cord-010119-t1x9gknd 6453 2 to to IN cord-010119-t1x9gknd 6453 3 the the DT cord-010119-t1x9gknd 6453 4 eluates eluate NNS cord-010119-t1x9gknd 6453 5 being be VBG cord-010119-t1x9gknd 6453 6 tested test VBN cord-010119-t1x9gknd 6453 7 on on IN cord-010119-t1x9gknd 6453 8 the the DT cord-010119-t1x9gknd 6453 9 automated automate VBN cord-010119-t1x9gknd 6453 10 platforms platform NNS cord-010119-t1x9gknd 6453 11 , , , cord-010119-t1x9gknd 6453 12 they -PRON- PRP cord-010119-t1x9gknd 6453 13 were be VBD cord-010119-t1x9gknd 6453 14 spun spin VBN cord-010119-t1x9gknd 6453 15 for for IN cord-010119-t1x9gknd 6453 16 5 5 CD cord-010119-t1x9gknd 6453 17 minutes minute NNS cord-010119-t1x9gknd 6453 18 twice twice RB cord-010119-t1x9gknd 6453 19 to to TO cord-010119-t1x9gknd 6453 20 remove remove VB cord-010119-t1x9gknd 6453 21 any any DT cord-010119-t1x9gknd 6453 22 RBC RBC NNP cord-010119-t1x9gknd 6453 23 debris debris NN cord-010119-t1x9gknd 6453 24 which which WDT cord-010119-t1x9gknd 6453 25 could could MD cord-010119-t1x9gknd 6453 26 cause cause VB cord-010119-t1x9gknd 6453 27 false false JJ cord-010119-t1x9gknd 6453 28 positive positive JJ cord-010119-t1x9gknd 6453 29 reactions reaction NNS cord-010119-t1x9gknd 6453 30 . . . cord-010119-t1x9gknd 6454 1 Results result NNS cord-010119-t1x9gknd 6454 2 / / SYM cord-010119-t1x9gknd 6454 3 Findings finding NNS cord-010119-t1x9gknd 6454 4 : : : cord-010119-t1x9gknd 6455 1 The the DT cord-010119-t1x9gknd 6455 2 eluates eluate NNS cord-010119-t1x9gknd 6455 3 prepared prepare VBD cord-010119-t1x9gknd 6455 4 ranged range VBD cord-010119-t1x9gknd 6455 5 in in IN cord-010119-t1x9gknd 6455 6 color color NN cord-010119-t1x9gknd 6455 7 : : : cord-010119-t1x9gknd 6455 8 5 5 CD cord-010119-t1x9gknd 6455 9 BB bb NN cord-010119-t1x9gknd 6455 10 , , , cord-010119-t1x9gknd 6455 11 14 14 CD cord-010119-t1x9gknd 6455 12 BG bg NN cord-010119-t1x9gknd 6455 13 and and CC cord-010119-t1x9gknd 6455 14 1 1 CD cord-010119-t1x9gknd 6455 15 BP BP NNP cord-010119-t1x9gknd 6455 16 . . . cord-010119-t1x9gknd 6456 1 The the DT cord-010119-t1x9gknd 6456 2 pH ph NN cord-010119-t1x9gknd 6456 3 of of IN cord-010119-t1x9gknd 6456 4 all all DT cord-010119-t1x9gknd 6456 5 eluates eluate NNS cord-010119-t1x9gknd 6456 6 ranged range VBD cord-010119-t1x9gknd 6456 7 from from IN cord-010119-t1x9gknd 6456 8 6.9 6.9 CD cord-010119-t1x9gknd 6456 9 - - SYM cord-010119-t1x9gknd 6456 10 8.1 8.1 CD cord-010119-t1x9gknd 6456 11 with with IN cord-010119-t1x9gknd 6456 12 the the DT cord-010119-t1x9gknd 6456 13 highest high JJS cord-010119-t1x9gknd 6456 14 percentage percentage NN cord-010119-t1x9gknd 6456 15 of of IN cord-010119-t1x9gknd 6456 16 eluates eluate NNS cord-010119-t1x9gknd 6456 17 at at IN cord-010119-t1x9gknd 6456 18 a a DT cord-010119-t1x9gknd 6456 19 pH ph NN cord-010119-t1x9gknd 6456 20 of of IN cord-010119-t1x9gknd 6456 21 8.1 8.1 CD cord-010119-t1x9gknd 6456 22 ( ( -LRB- cord-010119-t1x9gknd 6456 23 35 35 CD cord-010119-t1x9gknd 6456 24 % % NN cord-010119-t1x9gknd 6456 25 ) ) -RRB- cord-010119-t1x9gknd 6456 26 . . . cord-010119-t1x9gknd 6457 1 Sixteen sixteen CD cord-010119-t1x9gknd 6457 2 of of IN cord-010119-t1x9gknd 6457 3 the the DT cord-010119-t1x9gknd 6457 4 20 20 CD cord-010119-t1x9gknd 6457 5 eluates eluate NNS cord-010119-t1x9gknd 6457 6 tested test VBN cord-010119-t1x9gknd 6457 7 yielded yield VBD cord-010119-t1x9gknd 6457 8 the the DT cord-010119-t1x9gknd 6457 9 same same JJ cord-010119-t1x9gknd 6457 10 results result NNS cord-010119-t1x9gknd 6457 11 in in IN cord-010119-t1x9gknd 6457 12 both both DT cord-010119-t1x9gknd 6457 13 automation automation NN cord-010119-t1x9gknd 6457 14 platforms platform NNS cord-010119-t1x9gknd 6457 15 ( ( -LRB- cord-010119-t1x9gknd 6457 16 concordance concordance NN cord-010119-t1x9gknd 6457 17 of of IN cord-010119-t1x9gknd 6457 18 80 80 CD cord-010119-t1x9gknd 6457 19 % % NN cord-010119-t1x9gknd 6457 20 ) ) -RRB- cord-010119-t1x9gknd 6457 21 . . . cord-010119-t1x9gknd 6458 1 Four four CD cord-010119-t1x9gknd 6458 2 eluates eluate NNS cord-010119-t1x9gknd 6458 3 with with IN cord-010119-t1x9gknd 6458 4 different different JJ cord-010119-t1x9gknd 6458 5 results result NNS cord-010119-t1x9gknd 6458 6 are be VBP cord-010119-t1x9gknd 6458 7 summarized summarize VBN cord-010119-t1x9gknd 6458 8 in in IN cord-010119-t1x9gknd 6458 9 Table Table NNP cord-010119-t1x9gknd 6458 10 1 1 CD cord-010119-t1x9gknd 6458 11 . . . cord-010119-t1x9gknd 6459 1 Conclusion conclusion NN cord-010119-t1x9gknd 6459 2 : : : cord-010119-t1x9gknd 6460 1 The the DT cord-010119-t1x9gknd 6460 2 study study NN cord-010119-t1x9gknd 6460 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 6460 4 that that IN cord-010119-t1x9gknd 6460 5 both both DT cord-010119-t1x9gknd 6460 6 analyzers analyzer NNS cord-010119-t1x9gknd 6460 7 may may MD cord-010119-t1x9gknd 6460 8 be be VB cord-010119-t1x9gknd 6460 9 used use VBN cord-010119-t1x9gknd 6460 10 for for IN cord-010119-t1x9gknd 6460 11 eluate eluate JJ cord-010119-t1x9gknd 6460 12 investigations investigation NNS cord-010119-t1x9gknd 6460 13 . . . cord-010119-t1x9gknd 6461 1 Both both DT cord-010119-t1x9gknd 6461 2 methods method NNS cord-010119-t1x9gknd 6461 3 yielded yield VBD cord-010119-t1x9gknd 6461 4 apparent apparent JJ cord-010119-t1x9gknd 6461 5 false false JJ cord-010119-t1x9gknd 6461 6 positive positive JJ cord-010119-t1x9gknd 6461 7 results result NNS cord-010119-t1x9gknd 6461 8 on on IN cord-010119-t1x9gknd 6461 9 samples sample NNS cord-010119-t1x9gknd 6461 10 which which WDT cord-010119-t1x9gknd 6461 11 were be VBD cord-010119-t1x9gknd 6461 12 initially initially RB cord-010119-t1x9gknd 6461 13 DAT DAT NNP cord-010119-t1x9gknd 6461 14 negative negative JJ cord-010119-t1x9gknd 6461 15 . . . cord-010119-t1x9gknd 6462 1 The the DT cord-010119-t1x9gknd 6462 2 ECHO echo NN cord-010119-t1x9gknd 6462 3 was be VBD cord-010119-t1x9gknd 6462 4 more more RBR cord-010119-t1x9gknd 6462 5 sensitive sensitive JJ cord-010119-t1x9gknd 6462 6 , , , cord-010119-t1x9gknd 6462 7 yielding yield VBG cord-010119-t1x9gknd 6462 8 false false JJ cord-010119-t1x9gknd 6462 9 positive positive JJ cord-010119-t1x9gknd 6462 10 results result NNS cord-010119-t1x9gknd 6462 11 ( ( -LRB- cord-010119-t1x9gknd 6462 12 3 3 LS cord-010119-t1x9gknd 6462 13 ) ) -RRB- cord-010119-t1x9gknd 6462 14 when when WRB cord-010119-t1x9gknd 6462 15 the the DT cord-010119-t1x9gknd 6462 16 VISION vision NN cord-010119-t1x9gknd 6462 17 was be VBD cord-010119-t1x9gknd 6462 18 negative negative JJ cord-010119-t1x9gknd 6462 19 , , , cord-010119-t1x9gknd 6462 20 while while IN cord-010119-t1x9gknd 6462 21 the the DT cord-010119-t1x9gknd 6462 22 VISION vision NN cord-010119-t1x9gknd 6462 23 was be VBD cord-010119-t1x9gknd 6462 24 false false JJ cord-010119-t1x9gknd 6462 25 positive positive JJ cord-010119-t1x9gknd 6462 26 with with IN cord-010119-t1x9gknd 6462 27 one one CD cord-010119-t1x9gknd 6462 28 eluate eluate NN cord-010119-t1x9gknd 6462 29 with with IN cord-010119-t1x9gknd 6462 30 ECHO echo NN cord-010119-t1x9gknd 6462 31 negative negative JJ cord-010119-t1x9gknd 6462 32 . . . cord-010119-t1x9gknd 6463 1 There there EX cord-010119-t1x9gknd 6463 2 was be VBD cord-010119-t1x9gknd 6463 3 no no DT cord-010119-t1x9gknd 6463 4 apparent apparent JJ cord-010119-t1x9gknd 6463 5 association association NN cord-010119-t1x9gknd 6463 6 in in IN cord-010119-t1x9gknd 6463 7 the the DT cord-010119-t1x9gknd 6463 8 non non JJ cord-010119-t1x9gknd 6463 9 - - JJ cord-010119-t1x9gknd 6463 10 correlating correlate VBG cord-010119-t1x9gknd 6463 11 eluate eluate JJ cord-010119-t1x9gknd 6463 12 results result NNS cord-010119-t1x9gknd 6463 13 in in IN cord-010119-t1x9gknd 6463 14 relation relation NN cord-010119-t1x9gknd 6463 15 to to IN cord-010119-t1x9gknd 6463 16 color color NN cord-010119-t1x9gknd 6463 17 of of IN cord-010119-t1x9gknd 6463 18 eluate eluate NN cord-010119-t1x9gknd 6463 19 , , , cord-010119-t1x9gknd 6463 20 age age NN cord-010119-t1x9gknd 6463 21 of of IN cord-010119-t1x9gknd 6463 22 sample sample NN cord-010119-t1x9gknd 6463 23 when when WRB cord-010119-t1x9gknd 6463 24 eluate eluate NNP cord-010119-t1x9gknd 6463 25 was be VBD cord-010119-t1x9gknd 6463 26 prepared prepare VBN cord-010119-t1x9gknd 6463 27 , , , cord-010119-t1x9gknd 6463 28 or or CC cord-010119-t1x9gknd 6463 29 pH ph NN cord-010119-t1x9gknd 6463 30 of of IN cord-010119-t1x9gknd 6463 31 the the DT cord-010119-t1x9gknd 6463 32 eluate eluate NN cord-010119-t1x9gknd 6463 33 . . . cord-010119-t1x9gknd 6464 1 A a DT cord-010119-t1x9gknd 6464 2 larger large JJR cord-010119-t1x9gknd 6464 3 study study NN cord-010119-t1x9gknd 6464 4 may may MD cord-010119-t1x9gknd 6464 5 be be VB cord-010119-t1x9gknd 6464 6 able able JJ cord-010119-t1x9gknd 6464 7 to to TO cord-010119-t1x9gknd 6464 8 better better RB cord-010119-t1x9gknd 6464 9 elucidate elucidate VB cord-010119-t1x9gknd 6464 10 the the DT cord-010119-t1x9gknd 6464 11 apparent apparent JJ cord-010119-t1x9gknd 6464 12 false false JJ cord-010119-t1x9gknd 6464 13 positive positive JJ cord-010119-t1x9gknd 6464 14 results result NNS cord-010119-t1x9gknd 6464 15 noted note VBN cord-010119-t1x9gknd 6464 16 in in IN cord-010119-t1x9gknd 6464 17 this this DT cord-010119-t1x9gknd 6464 18 study study NN cord-010119-t1x9gknd 6464 19 between between IN cord-010119-t1x9gknd 6464 20 ECHO ECHO NNP cord-010119-t1x9gknd 6464 21 and and CC cord-010119-t1x9gknd 6464 22 VISION VISION NNP cord-010119-t1x9gknd 6464 23 eluate eluate JJ cord-010119-t1x9gknd 6464 24 study study NN cord-010119-t1x9gknd 6464 25 . . . cord-010119-t1x9gknd 6465 1 Background Background NNP cord-010119-t1x9gknd 6465 2 / / SYM cord-010119-t1x9gknd 6465 3 Case Case NNP cord-010119-t1x9gknd 6465 4 Studies Studies NNPS cord-010119-t1x9gknd 6465 5 : : : cord-010119-t1x9gknd 6465 6 Blood blood NN cord-010119-t1x9gknd 6465 7 agglutination agglutination NN cord-010119-t1x9gknd 6465 8 observed observe VBN cord-010119-t1x9gknd 6465 9 by by IN cord-010119-t1x9gknd 6465 10 Landsteiner Landsteiner NNP cord-010119-t1x9gknd 6465 11 in in IN cord-010119-t1x9gknd 6465 12 1900 1900 CD cord-010119-t1x9gknd 6465 13 led lead VBD cord-010119-t1x9gknd 6465 14 to to IN cord-010119-t1x9gknd 6465 15 the the DT cord-010119-t1x9gknd 6465 16 discovery discovery NN cord-010119-t1x9gknd 6465 17 of of IN cord-010119-t1x9gknd 6465 18 human human JJ cord-010119-t1x9gknd 6465 19 blood blood NN cord-010119-t1x9gknd 6465 20 groups group NNS cord-010119-t1x9gknd 6465 21 . . . cord-010119-t1x9gknd 6466 1 In in IN cord-010119-t1x9gknd 6466 2 the the DT cord-010119-t1x9gknd 6466 3 ABO ABO NNP cord-010119-t1x9gknd 6466 4 system system NN cord-010119-t1x9gknd 6466 5 > > XX cord-010119-t1x9gknd 6466 6 200 200 CD cord-010119-t1x9gknd 6466 7 alleles allele NNS cord-010119-t1x9gknd 6466 8 have have VBP cord-010119-t1x9gknd 6466 9 been be VBN cord-010119-t1x9gknd 6466 10 described describe VBN cord-010119-t1x9gknd 6466 11 . . . cord-010119-t1x9gknd 6467 1 The the DT cord-010119-t1x9gknd 6467 2 glycosyltransferase glycosyltransferase NN cord-010119-t1x9gknd 6467 3 encoded encode VBN cord-010119-t1x9gknd 6467 4 by by IN cord-010119-t1x9gknd 6467 5 most most JJS cord-010119-t1x9gknd 6467 6 results result NNS cord-010119-t1x9gknd 6467 7 in in IN cord-010119-t1x9gknd 6467 8 weakened weakened JJ cord-010119-t1x9gknd 6467 9 expression expression NN cord-010119-t1x9gknd 6467 10 of of IN cord-010119-t1x9gknd 6467 11 A a NN cord-010119-t1x9gknd 6467 12 or or CC cord-010119-t1x9gknd 6467 13 B b NN cord-010119-t1x9gknd 6467 14 or or CC cord-010119-t1x9gknd 6467 15 the the DT cord-010119-t1x9gknd 6467 16 null null NN cord-010119-t1x9gknd 6467 17 ( ( -LRB- cord-010119-t1x9gknd 6467 18 Group group NN cord-010119-t1x9gknd 6467 19 O o NN cord-010119-t1x9gknd 6467 20 ) ) -RRB- cord-010119-t1x9gknd 6467 21 phenotype phenotype NN cord-010119-t1x9gknd 6467 22 . . . cord-010119-t1x9gknd 6468 1 As as IN cord-010119-t1x9gknd 6468 2 testing test VBG cord-010119-t1x9gknd 6468 3 methods method NNS cord-010119-t1x9gknd 6468 4 and and CC cord-010119-t1x9gknd 6468 5 reagents reagent NNS cord-010119-t1x9gknd 6468 6 improve improve VBP cord-010119-t1x9gknd 6468 7 , , , cord-010119-t1x9gknd 6468 8 donors donor NNS cord-010119-t1x9gknd 6468 9 may may MD cord-010119-t1x9gknd 6468 10 appear appear VB cord-010119-t1x9gknd 6468 11 to to TO cord-010119-t1x9gknd 6468 12 change change VB cord-010119-t1x9gknd 6468 13 their -PRON- PRP$ cord-010119-t1x9gknd 6468 14 ABO ABO NNP cord-010119-t1x9gknd 6468 15 type type NN cord-010119-t1x9gknd 6468 16 . . . cord-010119-t1x9gknd 6469 1 Here here RB cord-010119-t1x9gknd 6469 2 we -PRON- PRP cord-010119-t1x9gknd 6469 3 describe describe VBP cord-010119-t1x9gknd 6469 4 a a DT cord-010119-t1x9gknd 6469 5 frequent frequent JJ cord-010119-t1x9gknd 6469 6 Group group NN cord-010119-t1x9gknd 6469 7 O o UH cord-010119-t1x9gknd 6469 8 blood blood NN cord-010119-t1x9gknd 6469 9 donor donor NN cord-010119-t1x9gknd 6469 10 ( ( -LRB- cord-010119-t1x9gknd 6469 11 38 38 CD cord-010119-t1x9gknd 6469 12 units unit NNS cord-010119-t1x9gknd 6469 13 over over IN cord-010119-t1x9gknd 6469 14 17 17 CD cord-010119-t1x9gknd 6469 15 years year NNS cord-010119-t1x9gknd 6469 16 ) ) -RRB- cord-010119-t1x9gknd 6469 17 who who WP cord-010119-t1x9gknd 6469 18 is be VBZ cord-010119-t1x9gknd 6469 19 actually actually RB cord-010119-t1x9gknd 6469 20 A a DT cord-010119-t1x9gknd 6469 21 w w NN cord-010119-t1x9gknd 6469 22 . . . cord-010119-t1x9gknd 6470 1 Study Study NNP cord-010119-t1x9gknd 6470 2 Design Design NNP cord-010119-t1x9gknd 6470 3 / / SYM cord-010119-t1x9gknd 6470 4 Methods method NNS cord-010119-t1x9gknd 6470 5 : : : cord-010119-t1x9gknd 6470 6 Donations donation NNS cord-010119-t1x9gknd 6470 7 were be VBD cord-010119-t1x9gknd 6470 8 tested test VBN cord-010119-t1x9gknd 6470 9 with with IN cord-010119-t1x9gknd 6470 10 the the DT cord-010119-t1x9gknd 6470 11 PK7300 PK7300 NNP cord-010119-t1x9gknd 6470 12 instrument instrument NN cord-010119-t1x9gknd 6470 13 ( ( -LRB- cord-010119-t1x9gknd 6470 14 Beckman Beckman NNP cord-010119-t1x9gknd 6470 15 Coulter Coulter NNP cord-010119-t1x9gknd 6470 16 Inc. Inc. NNP cord-010119-t1x9gknd 6470 17 ) ) -RRB- cord-010119-t1x9gknd 6470 18 . . . cord-010119-t1x9gknd 6471 1 Routine routine JJ cord-010119-t1x9gknd 6471 2 forward forward RB cord-010119-t1x9gknd 6471 3 and and CC cord-010119-t1x9gknd 6471 4 reverse reverse VB cord-010119-t1x9gknd 6471 5 ABO ABO NNP cord-010119-t1x9gknd 6471 6 testing testing NN cord-010119-t1x9gknd 6471 7 was be VBD cord-010119-t1x9gknd 6471 8 used use VBN cord-010119-t1x9gknd 6471 9 to to TO cord-010119-t1x9gknd 6471 10 investigate investigate VB cord-010119-t1x9gknd 6471 11 the the DT cord-010119-t1x9gknd 6471 12 discrepancy discrepancy NN cord-010119-t1x9gknd 6471 13 . . . cord-010119-t1x9gknd 6472 1 Molecular molecular JJ cord-010119-t1x9gknd 6472 2 studies study NNS cord-010119-t1x9gknd 6472 3 were be VBD cord-010119-t1x9gknd 6472 4 performed perform VBN cord-010119-t1x9gknd 6472 5 by by IN cord-010119-t1x9gknd 6472 6 DNA dna NN cord-010119-t1x9gknd 6472 7 sequencing sequencing NN cord-010119-t1x9gknd 6472 8 of of IN cord-010119-t1x9gknd 6472 9 ABO ABO NNP cord-010119-t1x9gknd 6472 10 introns intron NNS cord-010119-t1x9gknd 6472 11 1,2 1,2 CD cord-010119-t1x9gknd 6472 12 and and CC cord-010119-t1x9gknd 6472 13 4 4 CD cord-010119-t1x9gknd 6472 14 and and CC cord-010119-t1x9gknd 6472 15 exons exon NNS cord-010119-t1x9gknd 6472 16 6 6 CD cord-010119-t1x9gknd 6472 17 and and CC cord-010119-t1x9gknd 6472 18 7 7 CD cord-010119-t1x9gknd 6472 19 . . . cord-010119-t1x9gknd 6473 1 Specific specific JJ cord-010119-t1x9gknd 6473 2 primers primer NNS cord-010119-t1x9gknd 6473 3 located locate VBN cord-010119-t1x9gknd 6473 4 in in IN cord-010119-t1x9gknd 6473 5 the the DT cord-010119-t1x9gknd 6473 6 flanking flank VBG cord-010119-t1x9gknd 6473 7 intron intron NN cord-010119-t1x9gknd 6473 8 regions region NNS cord-010119-t1x9gknd 6473 9 of of IN cord-010119-t1x9gknd 6473 10 the the DT cord-010119-t1x9gknd 6473 11 blood blood NN cord-010119-t1x9gknd 6473 12 group group NN cord-010119-t1x9gknd 6473 13 gene gene NN cord-010119-t1x9gknd 6473 14 were be VBD cord-010119-t1x9gknd 6473 15 used use VBN cord-010119-t1x9gknd 6473 16 to to TO cord-010119-t1x9gknd 6473 17 amplify amplify VB cord-010119-t1x9gknd 6473 18 relevant relevant JJ cord-010119-t1x9gknd 6473 19 exons exon NNS cord-010119-t1x9gknd 6473 20 by by IN cord-010119-t1x9gknd 6473 21 PCR PCR NNP cord-010119-t1x9gknd 6473 22 . . . cord-010119-t1x9gknd 6474 1 The the DT cord-010119-t1x9gknd 6474 2 template template NN cord-010119-t1x9gknd 6474 3 used use VBN cord-010119-t1x9gknd 6474 4 is be VBZ cord-010119-t1x9gknd 6474 5 genomic genomic JJ cord-010119-t1x9gknd 6474 6 DNA dna NN cord-010119-t1x9gknd 6474 7 extracted extract VBN cord-010119-t1x9gknd 6474 8 from from IN cord-010119-t1x9gknd 6474 9 whole whole JJ cord-010119-t1x9gknd 6474 10 blood blood NN cord-010119-t1x9gknd 6474 11 collected collect VBN cord-010119-t1x9gknd 6474 12 in in IN cord-010119-t1x9gknd 6474 13 EDTA EDTA NNP cord-010119-t1x9gknd 6474 14 . . . cord-010119-t1x9gknd 6475 1 PCR PCR NNP cord-010119-t1x9gknd 6475 2 - - HYPH cord-010119-t1x9gknd 6475 3 amplified amplify VBN cord-010119-t1x9gknd 6475 4 exons exon NNS cord-010119-t1x9gknd 6475 5 are be VBP cord-010119-t1x9gknd 6475 6 subjected subject VBN cord-010119-t1x9gknd 6475 7 to to IN cord-010119-t1x9gknd 6475 8 bidirectional bidirectional JJ cord-010119-t1x9gknd 6475 9 DNA dna NN cord-010119-t1x9gknd 6475 10 sequence sequence NN cord-010119-t1x9gknd 6475 11 analysis analysis NN cord-010119-t1x9gknd 6475 12 using use VBG cord-010119-t1x9gknd 6475 13 standard standard JJ cord-010119-t1x9gknd 6475 14 Sanger Sanger NNP cord-010119-t1x9gknd 6475 15 dideoxy dideoxy NN cord-010119-t1x9gknd 6475 16 chemistry chemistry NN cord-010119-t1x9gknd 6475 17 . . . cord-010119-t1x9gknd 6476 1 Seqscape Seqscape NNP cord-010119-t1x9gknd 6476 2 software software NN cord-010119-t1x9gknd 6476 3 ( ( -LRB- cord-010119-t1x9gknd 6476 4 ABI ABI NNP cord-010119-t1x9gknd 6476 5 ) ) -RRB- cord-010119-t1x9gknd 6476 6 was be VBD cord-010119-t1x9gknd 6476 7 used use VBN cord-010119-t1x9gknd 6476 8 to to TO cord-010119-t1x9gknd 6476 9 analyze analyze VB cord-010119-t1x9gknd 6476 10 sequence sequence NN cord-010119-t1x9gknd 6476 11 data datum NNS cord-010119-t1x9gknd 6476 12 by by IN cord-010119-t1x9gknd 6476 13 comparing compare VBG cord-010119-t1x9gknd 6476 14 the the DT cord-010119-t1x9gknd 6476 15 obtained obtain VBN cord-010119-t1x9gknd 6476 16 sequence sequence NN cord-010119-t1x9gknd 6476 17 to to IN cord-010119-t1x9gknd 6476 18 a a DT cord-010119-t1x9gknd 6476 19 reference reference NN cord-010119-t1x9gknd 6476 20 sequence sequence NN cord-010119-t1x9gknd 6476 21 from from IN cord-010119-t1x9gknd 6476 22 NCBI NCBI NNP cord-010119-t1x9gknd 6476 23 . . . cord-010119-t1x9gknd 6477 1 Results/ Results/ . cord-010119-t1x9gknd 6478 1 Findings finding NNS cord-010119-t1x9gknd 6478 2 : : : cord-010119-t1x9gknd 6479 1 Serologic Serologic NNP cord-010119-t1x9gknd 6479 2 results result NNS cord-010119-t1x9gknd 6479 3 are be VBP cord-010119-t1x9gknd 6479 4 shown show VBN cord-010119-t1x9gknd 6479 5 in in IN cord-010119-t1x9gknd 6479 6 Table Table NNP cord-010119-t1x9gknd 6479 7 1 1 CD cord-010119-t1x9gknd 6479 8 . . . cord-010119-t1x9gknd 6480 1 Tests test NNS cord-010119-t1x9gknd 6480 2 with with IN cord-010119-t1x9gknd 6480 3 Anti Anti NNP cord-010119-t1x9gknd 6480 4 - - NNP cord-010119-t1x9gknd 6480 5 A A NNP cord-010119-t1x9gknd 6480 6 , , , cord-010119-t1x9gknd 6480 7 -A1 -a1 NN cord-010119-t1x9gknd 6480 8 , , , cord-010119-t1x9gknd 6480 9 -B -B : cord-010119-t1x9gknd 6480 10 anti anti NNP cord-010119-t1x9gknd 6480 11 - - NNP cord-010119-t1x9gknd 6480 12 A A NNP cord-010119-t1x9gknd 6480 13 , , , cord-010119-t1x9gknd 6480 14 B B NNP cord-010119-t1x9gknd 6480 15 were be VBD cord-010119-t1x9gknd 6480 16 negative negative JJ cord-010119-t1x9gknd 6480 17 as as IN cord-010119-t1x9gknd 6480 18 were be VBD cord-010119-t1x9gknd 6480 19 the the DT cord-010119-t1x9gknd 6480 20 A2 A2 NNP cord-010119-t1x9gknd 6480 21 cells cell NNS cord-010119-t1x9gknd 6480 22 in in IN cord-010119-t1x9gknd 6480 23 reverse reverse JJ cord-010119-t1x9gknd 6480 24 testing testing NN cord-010119-t1x9gknd 6480 25 . . . cord-010119-t1x9gknd 6481 1 The the DT cord-010119-t1x9gknd 6481 2 results result NNS cord-010119-t1x9gknd 6481 3 of of IN cord-010119-t1x9gknd 6481 4 DNA dna NN cord-010119-t1x9gknd 6481 5 sequencing sequencing NN cord-010119-t1x9gknd 6481 6 of of IN cord-010119-t1x9gknd 6481 7 ABO ABO NNP cord-010119-t1x9gknd 6481 8 introns intron NNS cord-010119-t1x9gknd 6481 9 / / SYM cord-010119-t1x9gknd 6481 10 exons exon NNS cord-010119-t1x9gknd 6481 11 are be VBP cord-010119-t1x9gknd 6481 12 shown show VBN cord-010119-t1x9gknd 6481 13 in in IN cord-010119-t1x9gknd 6481 14 Table Table NNP cord-010119-t1x9gknd 6481 15 2 2 CD cord-010119-t1x9gknd 6481 16 . . . cord-010119-t1x9gknd 6482 1 The the DT cord-010119-t1x9gknd 6482 2 significant significant JJ cord-010119-t1x9gknd 6482 3 changes change NNS cord-010119-t1x9gknd 6482 4 were be VBD cord-010119-t1x9gknd 6482 5 found find VBN cord-010119-t1x9gknd 6482 6 in in IN cord-010119-t1x9gknd 6482 7 exons exon NNS cord-010119-t1x9gknd 6482 8 6 6 CD cord-010119-t1x9gknd 6482 9 and and CC cord-010119-t1x9gknd 6482 10 7 7 CD cord-010119-t1x9gknd 6482 11 . . . cord-010119-t1x9gknd 6483 1 In in IN cord-010119-t1x9gknd 6483 2 exon exon NN cord-010119-t1x9gknd 6483 3 6 6 CD cord-010119-t1x9gknd 6483 4 there there EX cord-010119-t1x9gknd 6483 5 was be VBD cord-010119-t1x9gknd 6483 6 a a DT cord-010119-t1x9gknd 6483 7 nucleotide nucleotide NN cord-010119-t1x9gknd 6483 8 ( ( -LRB- cord-010119-t1x9gknd 6483 9 NT NT NNP cord-010119-t1x9gknd 6483 10 ) ) -RRB- cord-010119-t1x9gknd 6483 11 deletion deletion NN cord-010119-t1x9gknd 6483 12 of of IN cord-010119-t1x9gknd 6483 13 261 261 CD cord-010119-t1x9gknd 6483 14 G g NN cord-010119-t1x9gknd 6483 15 which which WDT cord-010119-t1x9gknd 6483 16 resulted result VBD cord-010119-t1x9gknd 6483 17 in in IN cord-010119-t1x9gknd 6483 18 a a DT cord-010119-t1x9gknd 6483 19 shortened shorten VBN cord-010119-t1x9gknd 6483 20 transcript transcript NN cord-010119-t1x9gknd 6483 21 due due IN cord-010119-t1x9gknd 6483 22 to to IN cord-010119-t1x9gknd 6483 23 a a DT cord-010119-t1x9gknd 6483 24 stop stop NN cord-010119-t1x9gknd 6483 25 codon codon NN cord-010119-t1x9gknd 6483 26 , , , cord-010119-t1x9gknd 6483 27 and and CC cord-010119-t1x9gknd 6483 28 another another DT cord-010119-t1x9gknd 6483 29 NT NT NNP cord-010119-t1x9gknd 6483 30 substitution substitution NN cord-010119-t1x9gknd 6483 31 lead lead NN cord-010119-t1x9gknd 6483 32 to to IN cord-010119-t1x9gknd 6483 33 the the DT cord-010119-t1x9gknd 6483 34 amino amino NN cord-010119-t1x9gknd 6483 35 acid acid NN cord-010119-t1x9gknd 6484 1 change change NNP cord-010119-t1x9gknd 6484 2 Gly117Ala Gly117Ala NNP cord-010119-t1x9gknd 6484 3 . . . cord-010119-t1x9gknd 6485 1 Mutations mutation NNS cord-010119-t1x9gknd 6485 2 in in IN cord-010119-t1x9gknd 6485 3 exon exon NN cord-010119-t1x9gknd 6485 4 7 7 CD cord-010119-t1x9gknd 6485 5 included include VBD cord-010119-t1x9gknd 6485 6 a a DT cord-010119-t1x9gknd 6485 7 NT NT NNP cord-010119-t1x9gknd 6485 8 substitution substitution NN cord-010119-t1x9gknd 6485 9 causing cause VBG cord-010119-t1x9gknd 6485 10 a a DT cord-010119-t1x9gknd 6485 11 Pro156-Leu Pro156-Leu NNP cord-010119-t1x9gknd 6485 12 change change NN cord-010119-t1x9gknd 6485 13 and and CC cord-010119-t1x9gknd 6485 14 a a DT cord-010119-t1x9gknd 6485 15 NT NT NNP cord-010119-t1x9gknd 6485 16 deletion deletion NN cord-010119-t1x9gknd 6485 17 1061C 1061c CD cord-010119-t1x9gknd 6485 18 resulting result VBG cord-010119-t1x9gknd 6485 19 in in IN cord-010119-t1x9gknd 6485 20 shortened shorten VBN cord-010119-t1x9gknd 6485 21 transcript transcript NN cord-010119-t1x9gknd 6485 22 . . . cord-010119-t1x9gknd 6486 1 Conclusion conclusion NN cord-010119-t1x9gknd 6486 2 : : : cord-010119-t1x9gknd 6486 3 Serologic Serologic NNP cord-010119-t1x9gknd 6486 4 testing testing NN cord-010119-t1x9gknd 6486 5 of of IN cord-010119-t1x9gknd 6486 6 the the DT cord-010119-t1x9gknd 6486 7 donor donor NN cord-010119-t1x9gknd 6486 8 plasma plasma NN cord-010119-t1x9gknd 6486 9 with with IN cord-010119-t1x9gknd 6486 10 A2 A2 NNP cord-010119-t1x9gknd 6486 11 cells cell NNS cord-010119-t1x9gknd 6486 12 was be VBD cord-010119-t1x9gknd 6486 13 nonreactive nonreactive JJ cord-010119-t1x9gknd 6486 14 revealing reveal VBG cord-010119-t1x9gknd 6486 15 the the DT cord-010119-t1x9gknd 6486 16 ABO ABO NNP cord-010119-t1x9gknd 6486 17 discrepancy discrepancy NN cord-010119-t1x9gknd 6486 18 . . . cord-010119-t1x9gknd 6487 1 Molecular molecular JJ cord-010119-t1x9gknd 6487 2 testing testing NN cord-010119-t1x9gknd 6487 3 confirmed confirm VBD cord-010119-t1x9gknd 6487 4 the the DT cord-010119-t1x9gknd 6487 5 donor donor NN cord-010119-t1x9gknd 6487 6 genotype genotype NN cord-010119-t1x9gknd 6487 7 is be VBZ cord-010119-t1x9gknd 6487 8 heterozygote heterozygote NN cord-010119-t1x9gknd 6488 1 A a LS cord-010119-t1x9gknd 6488 2 / / SYM cord-010119-t1x9gknd 6488 3 O o UH cord-010119-t1x9gknd 6488 4 [ [ -LRB- cord-010119-t1x9gknd 6488 5 ABO*O.01.01 ABO*O.01.01 NNP cord-010119-t1x9gknd 6488 6 / / SYM cord-010119-t1x9gknd 6488 7 ABO*AW.02 ABO*AW.02 NNP cord-010119-t1x9gknd 6488 8 ] ] -RRB- cord-010119-t1x9gknd 6488 9 which which WDT cord-010119-t1x9gknd 6488 10 predicts predict VBZ cord-010119-t1x9gknd 6488 11 A a DT cord-010119-t1x9gknd 6488 12 w w NN cord-010119-t1x9gknd 6488 13 phenotype phenotype NN cord-010119-t1x9gknd 6488 14 . . . cord-010119-t1x9gknd 6489 1 Normally normally RB cord-010119-t1x9gknd 6489 2 , , , cord-010119-t1x9gknd 6489 3 donor donor NN cord-010119-t1x9gknd 6489 4 RBCs rbc NNS cord-010119-t1x9gknd 6489 5 are be VBP cord-010119-t1x9gknd 6489 6 tested test VBN cord-010119-t1x9gknd 6489 7 with with IN cord-010119-t1x9gknd 6489 8 Anti Anti NNP cord-010119-t1x9gknd 6489 9 - - NNP cord-010119-t1x9gknd 6489 10 A A NNP cord-010119-t1x9gknd 6489 11 and and CC cord-010119-t1x9gknd 6489 12 -B -b ADD cord-010119-t1x9gknd 6489 13 and and CC cord-010119-t1x9gknd 6489 14 the the DT cord-010119-t1x9gknd 6489 15 reverse reverse JJ cord-010119-t1x9gknd 6489 16 type type NN cord-010119-t1x9gknd 6489 17 confirmed confirm VBN cord-010119-t1x9gknd 6489 18 by by IN cord-010119-t1x9gknd 6489 19 testing test VBG cord-010119-t1x9gknd 6489 20 the the DT cord-010119-t1x9gknd 6489 21 with with IN cord-010119-t1x9gknd 6489 22 A1 A1 NNP cord-010119-t1x9gknd 6489 23 and and CC cord-010119-t1x9gknd 6489 24 B B NNP cord-010119-t1x9gknd 6489 25 cells cell NNS cord-010119-t1x9gknd 6489 26 . . . cord-010119-t1x9gknd 6490 1 This this DT cord-010119-t1x9gknd 6490 2 ABO ABO NNP cord-010119-t1x9gknd 6490 3 discrepancy discrepancy NN cord-010119-t1x9gknd 6490 4 was be VBD cord-010119-t1x9gknd 6490 5 caused cause VBN cord-010119-t1x9gknd 6490 6 by by IN cord-010119-t1x9gknd 6490 7 the the DT cord-010119-t1x9gknd 6490 8 presence presence NN cord-010119-t1x9gknd 6490 9 of of IN cord-010119-t1x9gknd 6490 10 anti anti NNP cord-010119-t1x9gknd 6490 11 - - NNP cord-010119-t1x9gknd 6490 12 A1 A1 NNP cord-010119-t1x9gknd 6490 13 in in IN cord-010119-t1x9gknd 6490 14 the the DT cord-010119-t1x9gknd 6490 15 plasma plasma NN cord-010119-t1x9gknd 6490 16 causing cause VBG cord-010119-t1x9gknd 6490 17 the the DT cord-010119-t1x9gknd 6490 18 forward forward NN cord-010119-t1x9gknd 6490 19 and and CC cord-010119-t1x9gknd 6490 20 reverse reverse JJ cord-010119-t1x9gknd 6490 21 type type NN cord-010119-t1x9gknd 6490 22 to to TO cord-010119-t1x9gknd 6490 23 be be VB cord-010119-t1x9gknd 6490 24 interpreted interpret VBN cord-010119-t1x9gknd 6490 25 as as IN cord-010119-t1x9gknd 6490 26 group group NN cord-010119-t1x9gknd 6490 27 O. O. NNP cord-010119-t1x9gknd 6490 28 According accord VBG cord-010119-t1x9gknd 6490 29 to to IN cord-010119-t1x9gknd 6490 30 FDA FDA NNP cord-010119-t1x9gknd 6490 31 guidelines guideline NNS cord-010119-t1x9gknd 6490 32 , , , cord-010119-t1x9gknd 6490 33 the the DT cord-010119-t1x9gknd 6490 34 donor donor NN cord-010119-t1x9gknd 6490 35 is be VBZ cord-010119-t1x9gknd 6490 36 technically technically RB cord-010119-t1x9gknd 6490 37 group group NN cord-010119-t1x9gknd 6490 38 A a NN cord-010119-t1x9gknd 6490 39 , , , cord-010119-t1x9gknd 6490 40 and and CC cord-010119-t1x9gknd 6490 41 as as IN cord-010119-t1x9gknd 6490 42 such such JJ cord-010119-t1x9gknd 6490 43 all all DT cord-010119-t1x9gknd 6490 44 donations donation NNS cord-010119-t1x9gknd 6490 45 need need VBP cord-010119-t1x9gknd 6490 46 to to TO cord-010119-t1x9gknd 6490 47 be be VB cord-010119-t1x9gknd 6490 48 labeled label VBN cord-010119-t1x9gknd 6490 49 as as IN cord-010119-t1x9gknd 6490 50 group group NN cord-010119-t1x9gknd 6490 51 A. a. NN cord-010119-t1x9gknd 6490 52 The the DT cord-010119-t1x9gknd 6490 53 donor donor NN cord-010119-t1x9gknd 6490 54 was be VBD cord-010119-t1x9gknd 6490 55 contacted contact VBN cord-010119-t1x9gknd 6490 56 and and CC cord-010119-t1x9gknd 6490 57 instructed instruct VBN cord-010119-t1x9gknd 6490 58 to to TO cord-010119-t1x9gknd 6490 59 cease cease VB cord-010119-t1x9gknd 6490 60 donating donate VBG cord-010119-t1x9gknd 6490 61 blood blood NN cord-010119-t1x9gknd 6490 62 for for IN cord-010119-t1x9gknd 6490 63 transfusion transfusion NN cord-010119-t1x9gknd 6490 64 . . . cord-010119-t1x9gknd 6491 1 If if IN cord-010119-t1x9gknd 6491 2 donations donation NNS cord-010119-t1x9gknd 6491 3 continue continue VBP cord-010119-t1x9gknd 6491 4 , , , cord-010119-t1x9gknd 6491 5 the the DT cord-010119-t1x9gknd 6491 6 unit unit NN cord-010119-t1x9gknd 6491 7 labeled label VBD cord-010119-t1x9gknd 6491 8 group group NN cord-010119-t1x9gknd 6491 9 A A NNP cord-010119-t1x9gknd 6491 10 would would MD cord-010119-t1x9gknd 6491 11 likely likely RB cord-010119-t1x9gknd 6491 12 test test VB cord-010119-t1x9gknd 6491 13 as as IN cord-010119-t1x9gknd 6491 14 Group Group NNP cord-010119-t1x9gknd 6491 15 O O NNP cord-010119-t1x9gknd 6491 16 at at IN cord-010119-t1x9gknd 6491 17 the the DT cord-010119-t1x9gknd 6491 18 transfusion transfusion NN cord-010119-t1x9gknd 6491 19 facility facility NN cord-010119-t1x9gknd 6491 20 resulting result VBG cord-010119-t1x9gknd 6491 21 in in IN cord-010119-t1x9gknd 6491 22 an an DT cord-010119-t1x9gknd 6491 23 FDA FDA NNP cord-010119-t1x9gknd 6491 24 reportable reportable JJ cord-010119-t1x9gknd 6491 25 error error NN cord-010119-t1x9gknd 6491 26 . . . cord-010119-t1x9gknd 6492 1 There there EX cord-010119-t1x9gknd 6492 2 are be VBP cord-010119-t1x9gknd 6492 3 numerous numerous JJ cord-010119-t1x9gknd 6492 4 reports report NNS cord-010119-t1x9gknd 6492 5 in in IN cord-010119-t1x9gknd 6492 6 the the DT cord-010119-t1x9gknd 6492 7 literature literature NN cord-010119-t1x9gknd 6492 8 of of IN cord-010119-t1x9gknd 6492 9 the the DT cord-010119-t1x9gknd 6492 10 relative relative JJ cord-010119-t1x9gknd 6492 11 insusceptibility insusceptibility NN cord-010119-t1x9gknd 6492 12 of of IN cord-010119-t1x9gknd 6492 13 A2 A2 NNP cord-010119-t1x9gknd 6492 14 cells cell NNS cord-010119-t1x9gknd 6492 15 to to IN cord-010119-t1x9gknd 6492 16 destruction destruction NN cord-010119-t1x9gknd 6492 17 by by IN cord-010119-t1x9gknd 6492 18 anti anti JJ cord-010119-t1x9gknd 6492 19 - - JJ cord-010119-t1x9gknd 6492 20 A a JJ cord-010119-t1x9gknd 6492 21 , , , cord-010119-t1x9gknd 6492 22 however however RB cord-010119-t1x9gknd 6492 23 , , , cord-010119-t1x9gknd 6492 24 there there EX cord-010119-t1x9gknd 6492 25 is be VBZ cord-010119-t1x9gknd 6492 26 one one CD cord-010119-t1x9gknd 6492 27 hemolytic hemolytic JJ cord-010119-t1x9gknd 6492 28 transfusion transfusion NN cord-010119-t1x9gknd 6492 29 reaction reaction NN cord-010119-t1x9gknd 6492 30 to to IN cord-010119-t1x9gknd 6492 31 A a DT cord-010119-t1x9gknd 6492 32 x x NN cord-010119-t1x9gknd 6492 33 blood blood NN cord-010119-t1x9gknd 6492 34 transfused transfuse VBN cord-010119-t1x9gknd 6492 35 to to IN cord-010119-t1x9gknd 6492 36 a a DT cord-010119-t1x9gknd 6492 37 patient patient NN cord-010119-t1x9gknd 6492 38 with with IN cord-010119-t1x9gknd 6492 39 a a DT cord-010119-t1x9gknd 6492 40 potent potent JJ cord-010119-t1x9gknd 6492 41 anti anti JJ cord-010119-t1x9gknd 6492 42 - - JJ cord-010119-t1x9gknd 6492 43 A a JJ cord-010119-t1x9gknd 6492 44 titer titer NN cord-010119-t1x9gknd 6492 45 > > XX cord-010119-t1x9gknd 6492 46 1:1000 1:1000 NN cord-010119-t1x9gknd 6492 47 . . . cord-010119-t1x9gknd 6493 1 ( ( -LRB- cord-010119-t1x9gknd 6493 2 Schmidt Schmidt NNP cord-010119-t1x9gknd 6493 3 , , , cord-010119-t1x9gknd 6493 4 Nacarrow Nacarrow NNP cord-010119-t1x9gknd 6493 5 et et NNP cord-010119-t1x9gknd 6493 6 al al NNP cord-010119-t1x9gknd 6493 7 . . NNP cord-010119-t1x9gknd 6493 8 1959 1959 CD cord-010119-t1x9gknd 6493 9 ) ) -RRB- cord-010119-t1x9gknd 6493 10 . . . cord-010119-t1x9gknd 6494 1 A a DT cord-010119-t1x9gknd 6494 2 review review NN cord-010119-t1x9gknd 6494 3 of of IN cord-010119-t1x9gknd 6494 4 transfusion transfusion NN cord-010119-t1x9gknd 6494 5 recipients recipient NNS cord-010119-t1x9gknd 6494 6 of of IN cord-010119-t1x9gknd 6494 7 the the DT cord-010119-t1x9gknd 6494 8 donor donor NN cord-010119-t1x9gknd 6494 9 reported report VBN cord-010119-t1x9gknd 6494 10 here here RB cord-010119-t1x9gknd 6494 11 did do VBD cord-010119-t1x9gknd 6494 12 not not RB cord-010119-t1x9gknd 6494 13 reveal reveal VB cord-010119-t1x9gknd 6494 14 any any DT cord-010119-t1x9gknd 6494 15 untoward untoward JJ cord-010119-t1x9gknd 6494 16 reaction reaction NN cord-010119-t1x9gknd 6494 17 after after IN cord-010119-t1x9gknd 6494 18 transfusion transfusion NN cord-010119-t1x9gknd 6494 19 . . . cord-010119-t1x9gknd 6495 1 136A 136a CD cord-010119-t1x9gknd 6496 1 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 6496 2 2017 2017 CD cord-010119-t1x9gknd 6496 3 Vol Vol NNP cord-010119-t1x9gknd 6496 4 . . . cord-010119-t1x9gknd 6497 1 57 57 CD cord-010119-t1x9gknd 6498 1 Supplement supplement NN cord-010119-t1x9gknd 6498 2 S3 s3 NN cord-010119-t1x9gknd 6498 3 extraction extraction NN cord-010119-t1x9gknd 6498 4 of of IN cord-010119-t1x9gknd 6498 5 gDNA gdna NN cord-010119-t1x9gknd 6498 6 from from IN cord-010119-t1x9gknd 6498 7 EDTA EDTA NNP cord-010119-t1x9gknd 6498 8 - - HYPH cord-010119-t1x9gknd 6498 9 anticoagulated anticoagulate VBN cord-010119-t1x9gknd 6498 10 whole whole JJ cord-010119-t1x9gknd 6498 11 blood blood NN cord-010119-t1x9gknd 6498 12 from from IN cord-010119-t1x9gknd 6498 13 pilot pilot NN cord-010119-t1x9gknd 6498 14 tubes tube NNS cord-010119-t1x9gknd 6498 15 derived derive VBN cord-010119-t1x9gknd 6498 16 from from IN cord-010119-t1x9gknd 6498 17 the the DT cord-010119-t1x9gknd 6498 18 unit unit NN cord-010119-t1x9gknd 6498 19 . . . cord-010119-t1x9gknd 6499 1 DNA dna NN cord-010119-t1x9gknd 6499 2 extraction extraction NN cord-010119-t1x9gknd 6499 3 from from IN cord-010119-t1x9gknd 6499 4 whole whole JJ cord-010119-t1x9gknd 6499 5 blood blood NN cord-010119-t1x9gknd 6499 6 is be VBZ cord-010119-t1x9gknd 6499 7 performed perform VBN cord-010119-t1x9gknd 6499 8 on on IN cord-010119-t1x9gknd 6499 9 up up IN cord-010119-t1x9gknd 6499 10 to to TO cord-010119-t1x9gknd 6499 11 96 96 CD cord-010119-t1x9gknd 6499 12 blood blood NN cord-010119-t1x9gknd 6499 13 tubes tube NNS cord-010119-t1x9gknd 6499 14 using use VBG cord-010119-t1x9gknd 6499 15 the the DT cord-010119-t1x9gknd 6499 16 BioRobot BioRobot NNP cord-010119-t1x9gknd 6499 17 Universal Universal NNP cord-010119-t1x9gknd 6499 18 System System NNP cord-010119-t1x9gknd 6499 19 ( ( -LRB- cord-010119-t1x9gknd 6499 20 QIAGEN QIAGEN NNP cord-010119-t1x9gknd 6499 21 ) ) -RRB- cord-010119-t1x9gknd 6499 22 . . . cord-010119-t1x9gknd 6500 1 There there EX cord-010119-t1x9gknd 6500 2 is be VBZ cord-010119-t1x9gknd 6500 3 no no DT cord-010119-t1x9gknd 6500 4 information information NN cord-010119-t1x9gknd 6500 5 on on IN cord-010119-t1x9gknd 6500 6 the the DT cord-010119-t1x9gknd 6500 7 maximum maximum JJ cord-010119-t1x9gknd 6500 8 acceptable acceptable JJ cord-010119-t1x9gknd 6500 9 age age NN cord-010119-t1x9gknd 6500 10 of of IN cord-010119-t1x9gknd 6500 11 the the DT cord-010119-t1x9gknd 6500 12 blood blood NN cord-010119-t1x9gknd 6500 13 for for IN cord-010119-t1x9gknd 6500 14 this this DT cord-010119-t1x9gknd 6500 15 purpose purpose NN cord-010119-t1x9gknd 6500 16 , , , cord-010119-t1x9gknd 6500 17 either either CC cord-010119-t1x9gknd 6500 18 from from IN cord-010119-t1x9gknd 6500 19 the the DT cord-010119-t1x9gknd 6500 20 vendor vendor NN cord-010119-t1x9gknd 6500 21 or or CC cord-010119-t1x9gknd 6500 22 in in IN cord-010119-t1x9gknd 6500 23 peer peer NN cord-010119-t1x9gknd 6500 24 - - HYPH cord-010119-t1x9gknd 6500 25 reviewed review VBN cord-010119-t1x9gknd 6500 26 literature literature NN cord-010119-t1x9gknd 6500 27 . . . cord-010119-t1x9gknd 6501 1 We -PRON- PRP cord-010119-t1x9gknd 6501 2 set set VBD cord-010119-t1x9gknd 6501 3 out out RP cord-010119-t1x9gknd 6501 4 to to TO cord-010119-t1x9gknd 6501 5 assess assess VB cord-010119-t1x9gknd 6501 6 if if IN cord-010119-t1x9gknd 6501 7 blood blood NN cord-010119-t1x9gknd 6501 8 up up IN cord-010119-t1x9gknd 6501 9 to to TO cord-010119-t1x9gknd 6501 10 15 15 CD cord-010119-t1x9gknd 6501 11 days day NNS cord-010119-t1x9gknd 6501 12 post post NN cord-010119-t1x9gknd 6501 13 collection collection NN cord-010119-t1x9gknd 6502 1 yielded yield VBN cord-010119-t1x9gknd 6502 2 suitable suitable JJ cord-010119-t1x9gknd 6502 3 gDNA gdna NN cord-010119-t1x9gknd 6502 4 for for IN cord-010119-t1x9gknd 6502 5 downstream downstream JJ cord-010119-t1x9gknd 6502 6 RBC RBC NNP cord-010119-t1x9gknd 6502 7 genotyping genotyping NN cord-010119-t1x9gknd 6502 8 . . . cord-010119-t1x9gknd 6503 1 Study Study NNP cord-010119-t1x9gknd 6503 2 Design Design NNP cord-010119-t1x9gknd 6503 3 / / SYM cord-010119-t1x9gknd 6503 4 Method method NN cord-010119-t1x9gknd 6503 5 : : : cord-010119-t1x9gknd 6504 1 92 92 CD cord-010119-t1x9gknd 6504 2 EDTA EDTA NNP cord-010119-t1x9gknd 6504 3 blood blood NN cord-010119-t1x9gknd 6504 4 tubes tube NNS cord-010119-t1x9gknd 6504 5 collected collect VBN cord-010119-t1x9gknd 6504 6 from from IN cord-010119-t1x9gknd 6504 7 random random JJ cord-010119-t1x9gknd 6504 8 blood blood NN cord-010119-t1x9gknd 6504 9 donors donor NNS cord-010119-t1x9gknd 6504 10 were be VBD cord-010119-t1x9gknd 6504 11 used use VBN cord-010119-t1x9gknd 6504 12 to to TO cord-010119-t1x9gknd 6504 13 extract extract VB cord-010119-t1x9gknd 6504 14 DNA dna NN cord-010119-t1x9gknd 6504 15 from from IN cord-010119-t1x9gknd 6504 16 200 200 CD cord-010119-t1x9gknd 6504 17 microliters microliter NNS cord-010119-t1x9gknd 6504 18 of of IN cord-010119-t1x9gknd 6504 19 whole whole JJ cord-010119-t1x9gknd 6504 20 blood blood NN cord-010119-t1x9gknd 6504 21 on on IN cord-010119-t1x9gknd 6504 22 day day NN cord-010119-t1x9gknd 6504 23 5 5 CD cord-010119-t1x9gknd 6504 24 , , , cord-010119-t1x9gknd 6504 25 12 12 CD cord-010119-t1x9gknd 6504 26 and and CC cord-010119-t1x9gknd 6504 27 15 15 CD cord-010119-t1x9gknd 6504 28 days day NNS cord-010119-t1x9gknd 6504 29 post post NN cord-010119-t1x9gknd 6504 30 collection collection NN cord-010119-t1x9gknd 6504 31 . . . cord-010119-t1x9gknd 6505 1 Blood blood NN cord-010119-t1x9gknd 6505 2 samples sample NNS cord-010119-t1x9gknd 6505 3 were be VBD cord-010119-t1x9gknd 6505 4 stored store VBN cord-010119-t1x9gknd 6505 5 at at IN cord-010119-t1x9gknd 6505 6 2 2 CD cord-010119-t1x9gknd 6505 7 - - HYPH cord-010119-t1x9gknd 6505 8 8C 8c CD cord-010119-t1x9gknd 6505 9 before before IN cord-010119-t1x9gknd 6505 10 and and CC cord-010119-t1x9gknd 6505 11 after after IN cord-010119-t1x9gknd 6505 12 extraction extraction NN cord-010119-t1x9gknd 6505 13 . . . cord-010119-t1x9gknd 6506 1 Tubes tube NNS cord-010119-t1x9gknd 6506 2 were be VBD cord-010119-t1x9gknd 6506 3 brought bring VBN cord-010119-t1x9gknd 6506 4 to to IN cord-010119-t1x9gknd 6506 5 room room NN cord-010119-t1x9gknd 6506 6 temperature temperature NN cord-010119-t1x9gknd 6506 7 and and CC cord-010119-t1x9gknd 6506 8 rocked rock VBD cord-010119-t1x9gknd 6506 9 before before IN cord-010119-t1x9gknd 6506 10 loading load VBG cord-010119-t1x9gknd 6506 11 on on IN cord-010119-t1x9gknd 6506 12 the the DT cord-010119-t1x9gknd 6506 13 BioRobot BioRobot NNP cord-010119-t1x9gknd 6506 14 . . . cord-010119-t1x9gknd 6507 1 Extraction extraction NN cord-010119-t1x9gknd 6507 2 was be VBD cord-010119-t1x9gknd 6507 3 performed perform VBN cord-010119-t1x9gknd 6507 4 using use VBG cord-010119-t1x9gknd 6507 5 the the DT cord-010119-t1x9gknd 6507 6 MDx MDx NNS cord-010119-t1x9gknd 6507 7 Blood Blood NNP cord-010119-t1x9gknd 6507 8 Minikit Minikit NNP cord-010119-t1x9gknd 6507 9 ( ( -LRB- cord-010119-t1x9gknd 6507 10 QIAGEN QIAGEN NNP cord-010119-t1x9gknd 6507 11 ) ) -RRB- cord-010119-t1x9gknd 6507 12 . . . cord-010119-t1x9gknd 6508 1 Resulting result VBG cord-010119-t1x9gknd 6508 2 DNA dna NN cord-010119-t1x9gknd 6508 3 samples sample NNS cord-010119-t1x9gknd 6508 4 were be VBD cord-010119-t1x9gknd 6508 5 assessed assess VBN cord-010119-t1x9gknd 6508 6 for for IN cord-010119-t1x9gknd 6508 7 gDNA gdna JJ cord-010119-t1x9gknd 6508 8 yield yield NN cord-010119-t1x9gknd 6508 9 and and CC cord-010119-t1x9gknd 6508 10 absorbance absorbance NN cord-010119-t1x9gknd 6508 11 A260 A260 NNS cord-010119-t1x9gknd 6508 12 / / SYM cord-010119-t1x9gknd 6508 13 A280 A280 NNPS cord-010119-t1x9gknd 6508 14 using use VBG cord-010119-t1x9gknd 6508 15 a a DT cord-010119-t1x9gknd 6508 16 Nanodrop Nanodrop NNP cord-010119-t1x9gknd 6508 17 2000 2000 CD cord-010119-t1x9gknd 6509 1 ( ( -LRB- cord-010119-t1x9gknd 6509 2 Thermo Thermo NNP cord-010119-t1x9gknd 6509 3 Scientific Scientific NNP cord-010119-t1x9gknd 6509 4 ) ) -RRB- cord-010119-t1x9gknd 6509 5 . . . cord-010119-t1x9gknd 6510 1 The the DT cord-010119-t1x9gknd 6510 2 extracted extract VBN cord-010119-t1x9gknd 6510 3 gDNA gdna NN cord-010119-t1x9gknd 6510 4 was be VBD cord-010119-t1x9gknd 6510 5 tested test VBN cord-010119-t1x9gknd 6510 6 using use VBG cord-010119-t1x9gknd 6510 7 PreciseType PreciseType NNP cord-010119-t1x9gknd 6510 8 HEA HEA NNP cord-010119-t1x9gknd 6510 9 Molecular Molecular NNP cord-010119-t1x9gknd 6510 10 BeadChip BeadChip NNP cord-010119-t1x9gknd 6510 11 ( ( -LRB- cord-010119-t1x9gknd 6510 12 " " `` cord-010119-t1x9gknd 6510 13 HEA HEA NNP cord-010119-t1x9gknd 6510 14 " " '' cord-010119-t1x9gknd 6510 15 , , , cord-010119-t1x9gknd 6510 16 Immucor Immucor NNP cord-010119-t1x9gknd 6510 17 ) ) -RRB- cord-010119-t1x9gknd 6510 18 and and CC cord-010119-t1x9gknd 6510 19 failure failure NN cord-010119-t1x9gknd 6510 20 rates rate NNS cord-010119-t1x9gknd 6510 21 on on IN cord-010119-t1x9gknd 6510 22 both both CC cord-010119-t1x9gknd 6510 23 the the DT cord-010119-t1x9gknd 6510 24 BioRobot BioRobot NNP cord-010119-t1x9gknd 6510 25 and and CC cord-010119-t1x9gknd 6510 26 the the DT cord-010119-t1x9gknd 6510 27 HEA HEA NNP cord-010119-t1x9gknd 6510 28 were be VBD cord-010119-t1x9gknd 6510 29 assessed assess VBN cord-010119-t1x9gknd 6510 30 . . . cord-010119-t1x9gknd 6511 1 Results/ Results/ . cord-010119-t1x9gknd 6512 1 Finding finding NN cord-010119-t1x9gknd 6512 2 : : : cord-010119-t1x9gknd 6513 1 All all DT cord-010119-t1x9gknd 6513 2 three three CD cord-010119-t1x9gknd 6513 3 extractions extraction NNS cord-010119-t1x9gknd 6513 4 were be VBD cord-010119-t1x9gknd 6513 5 successful successful JJ cord-010119-t1x9gknd 6513 6 with with IN cord-010119-t1x9gknd 6513 7 no no DT cord-010119-t1x9gknd 6513 8 invalids invalid NNS cord-010119-t1x9gknd 6513 9 ( ( -LRB- cord-010119-t1x9gknd 6513 10 result50 result50 NNS cord-010119-t1x9gknd 6513 11 ) ) -RRB- cord-010119-t1x9gknd 6513 12 on on IN cord-010119-t1x9gknd 6513 13 the the DT cord-010119-t1x9gknd 6513 14 BioRobot BioRobot NNP cord-010119-t1x9gknd 6513 15 Universal Universal NNP cord-010119-t1x9gknd 6513 16 Report Report NNP cord-010119-t1x9gknd 6513 17 . . . cord-010119-t1x9gknd 6514 1 No no DT cord-010119-t1x9gknd 6514 2 evidence evidence NN cord-010119-t1x9gknd 6514 3 of of IN cord-010119-t1x9gknd 6514 4 visible visible JJ cord-010119-t1x9gknd 6514 5 clots clot NNS cord-010119-t1x9gknd 6514 6 or or CC cord-010119-t1x9gknd 6514 7 splatter splatter NN cord-010119-t1x9gknd 6514 8 during during IN cord-010119-t1x9gknd 6514 9 extraction extraction NN cord-010119-t1x9gknd 6514 10 was be VBD cord-010119-t1x9gknd 6514 11 noted note VBN cord-010119-t1x9gknd 6514 12 by by IN cord-010119-t1x9gknd 6514 13 the the DT cord-010119-t1x9gknd 6514 14 technologist technologist NN cord-010119-t1x9gknd 6514 15 . . . cord-010119-t1x9gknd 6515 1 Out out IN cord-010119-t1x9gknd 6515 2 of of IN cord-010119-t1x9gknd 6515 3 the the DT cord-010119-t1x9gknd 6515 4 92 92 CD cord-010119-t1x9gknd 6515 5 samples sample NNS cord-010119-t1x9gknd 6515 6 , , , cord-010119-t1x9gknd 6515 7 20 20 CD cord-010119-t1x9gknd 6515 8 samples sample NNS cord-010119-t1x9gknd 6515 9 were be VBD cord-010119-t1x9gknd 6515 10 chosen choose VBN cord-010119-t1x9gknd 6515 11 at at IN cord-010119-t1x9gknd 6515 12 random random JJ cord-010119-t1x9gknd 6515 13 and and CC cord-010119-t1x9gknd 6515 14 concentrations concentration NNS cord-010119-t1x9gknd 6515 15 were be VBD cord-010119-t1x9gknd 6515 16 measured measure VBN cord-010119-t1x9gknd 6515 17 using use VBG cord-010119-t1x9gknd 6515 18 Nanodrop Nanodrop NNP cord-010119-t1x9gknd 6515 19 for for IN cord-010119-t1x9gknd 6515 20 each each DT cord-010119-t1x9gknd 6515 21 of of IN cord-010119-t1x9gknd 6515 22 the the DT cord-010119-t1x9gknd 6515 23 extracted extract VBN cord-010119-t1x9gknd 6515 24 plates plate NNS cord-010119-t1x9gknd 6515 25 . . . cord-010119-t1x9gknd 6516 1 DNA dna NN cord-010119-t1x9gknd 6516 2 concentrations concentration NNS cord-010119-t1x9gknd 6516 3 ranged range VBD cord-010119-t1x9gknd 6516 4 from from IN cord-010119-t1x9gknd 6516 5 10.8 10.8 CD cord-010119-t1x9gknd 6516 6 to to IN cord-010119-t1x9gknd 6517 1 62.6 62.6 CD cord-010119-t1x9gknd 6517 2 ng ng NNP cord-010119-t1x9gknd 6517 3 / / SYM cord-010119-t1x9gknd 6517 4 uL. uL. VBD cord-010119-t1x9gknd 6517 5 All all DT cord-010119-t1x9gknd 6517 6 readings reading NNS cord-010119-t1x9gknd 6517 7 with with IN cord-010119-t1x9gknd 6517 8 the the DT cord-010119-t1x9gknd 6517 9 exception exception NN cord-010119-t1x9gknd 6517 10 of of IN cord-010119-t1x9gknd 6517 11 1 1 CD cord-010119-t1x9gknd 6517 12 ( ( -LRB- cord-010119-t1x9gknd 6517 13 10.8ng/ 10.8ng/ CD cord-010119-t1x9gknd 6517 14 uL uL NNP cord-010119-t1x9gknd 6517 15 ) ) -RRB- cord-010119-t1x9gknd 6517 16 had have VBD cord-010119-t1x9gknd 6517 17 concentrations concentration NNS cord-010119-t1x9gknd 6517 18 > > NFP cord-010119-t1x9gknd 6517 19 5 5 CD cord-010119-t1x9gknd 6517 20 15ng/ 15ng/ CD cord-010119-t1x9gknd 6518 1 uL. uL. NNP cord-010119-t1x9gknd 6518 2 Interestingly interestingly RB cord-010119-t1x9gknd 6518 3 , , , cord-010119-t1x9gknd 6518 4 the the DT cord-010119-t1x9gknd 6518 5 one one NN cord-010119-t1x9gknd 6518 6 that that WDT cord-010119-t1x9gknd 6518 7 was be VBD cord-010119-t1x9gknd 6518 8 < < XX cord-010119-t1x9gknd 6518 9 15ng/ 15ng/ CD cord-010119-t1x9gknd 6518 10 uL uL NNP cord-010119-t1x9gknd 6518 11 on on IN cord-010119-t1x9gknd 6518 12 day day NN cord-010119-t1x9gknd 6518 13 5 5 CD cord-010119-t1x9gknd 6518 14 , , , cord-010119-t1x9gknd 6518 15 yielded yield VBD cord-010119-t1x9gknd 6518 16 > > XX cord-010119-t1x9gknd 6519 1 515ng 515ng NNP cord-010119-t1x9gknd 6519 2 / / SYM cord-010119-t1x9gknd 6519 3 uL ul NN cord-010119-t1x9gknd 6519 4 on on IN cord-010119-t1x9gknd 6519 5 day day NN cord-010119-t1x9gknd 6519 6 12 12 CD cord-010119-t1x9gknd 6519 7 and and CC cord-010119-t1x9gknd 6519 8 15 15 CD cord-010119-t1x9gknd 6519 9 post post NN cord-010119-t1x9gknd 6519 10 collection collection NN cord-010119-t1x9gknd 6519 11 . . . cord-010119-t1x9gknd 6520 1 Over over IN cord-010119-t1x9gknd 6520 2 the the DT cord-010119-t1x9gknd 6520 3 next next JJ cord-010119-t1x9gknd 6520 4 3 3 CD cord-010119-t1x9gknd 6520 5 months month NNS cord-010119-t1x9gknd 6520 6 , , , cord-010119-t1x9gknd 6520 7 67 67 CD cord-010119-t1x9gknd 6520 8 sets set NNS cord-010119-t1x9gknd 6520 9 of of IN cord-010119-t1x9gknd 6520 10 92 92 CD cord-010119-t1x9gknd 6520 11 samples sample NNS cord-010119-t1x9gknd 6520 12 were be VBD cord-010119-t1x9gknd 6520 13 extracted extract VBN cord-010119-t1x9gknd 6520 14 and and CC cord-010119-t1x9gknd 6520 15 tested test VBN cord-010119-t1x9gknd 6520 16 by by IN cord-010119-t1x9gknd 6520 17 HEA HEA NNP cord-010119-t1x9gknd 6520 18 . . . cord-010119-t1x9gknd 6521 1 Eighty eighty CD cord-010119-t1x9gknd 6521 2 - - HYPH cord-010119-t1x9gknd 6521 3 three three CD cord-010119-t1x9gknd 6521 4 ( ( -LRB- cord-010119-t1x9gknd 6521 5 1.3 1.3 CD cord-010119-t1x9gknd 6521 6 % % NN cord-010119-t1x9gknd 6521 7 ) ) -RRB- cord-010119-t1x9gknd 6521 8 failed fail VBN cord-010119-t1x9gknd 6521 9 extraction extraction NN cord-010119-t1x9gknd 6521 10 and and CC cord-010119-t1x9gknd 6521 11 82 82 CD cord-010119-t1x9gknd 6521 12 ( ( -LRB- cord-010119-t1x9gknd 6521 13 1.3 1.3 CD cord-010119-t1x9gknd 6521 14 % % NN cord-010119-t1x9gknd 6521 15 ) ) -RRB- cord-010119-t1x9gknd 6521 16 failed fail VBD cord-010119-t1x9gknd 6521 17 HEA HEA NNP cord-010119-t1x9gknd 6521 18 . . . cord-010119-t1x9gknd 6522 1 None none NN cord-010119-t1x9gknd 6522 2 of of IN cord-010119-t1x9gknd 6522 3 the the DT cord-010119-t1x9gknd 6522 4 samples sample NNS cord-010119-t1x9gknd 6522 5 that that WDT cord-010119-t1x9gknd 6522 6 failed fail VBD cord-010119-t1x9gknd 6522 7 extraction extraction NN cord-010119-t1x9gknd 6522 8 were be VBD cord-010119-t1x9gknd 6522 9 12 12 CD cord-010119-t1x9gknd 6522 10 or or CC cord-010119-t1x9gknd 6522 11 15 15 CD cord-010119-t1x9gknd 6522 12 days day NNS cord-010119-t1x9gknd 6522 13 post post NN cord-010119-t1x9gknd 6522 14 collection collection NN cord-010119-t1x9gknd 6522 15 ; ; : cord-010119-t1x9gknd 6522 16 none none NN cord-010119-t1x9gknd 6522 17 of of IN cord-010119-t1x9gknd 6522 18 those those DT cord-010119-t1x9gknd 6522 19 that that WDT cord-010119-t1x9gknd 6522 20 failed fail VBD cord-010119-t1x9gknd 6522 21 HEA HEA NNP cord-010119-t1x9gknd 6522 22 were be VBD cord-010119-t1x9gknd 6522 23 15 15 CD cord-010119-t1x9gknd 6522 24 days day NNS cord-010119-t1x9gknd 6522 25 post post NN cord-010119-t1x9gknd 6522 26 collection collection NN cord-010119-t1x9gknd 6522 27 ; ; : cord-010119-t1x9gknd 6522 28 3.7 3.7 CD cord-010119-t1x9gknd 6522 29 % % NN cord-010119-t1x9gknd 6522 30 were be VBD cord-010119-t1x9gknd 6522 31 > > XX cord-010119-t1x9gknd 6522 32 10 10 CD cord-010119-t1x9gknd 6522 33 < < SYM cord-010119-t1x9gknd 6522 34 15 15 CD cord-010119-t1x9gknd 6522 35 days day NNS cord-010119-t1x9gknd 6522 36 post post NN cord-010119-t1x9gknd 6522 37 collection collection NN cord-010119-t1x9gknd 6522 38 . . . cord-010119-t1x9gknd 6523 1 Conclusion conclusion NN cord-010119-t1x9gknd 6523 2 : : : cord-010119-t1x9gknd 6524 1 Based base VBN cord-010119-t1x9gknd 6524 2 on on IN cord-010119-t1x9gknd 6524 3 these these DT cord-010119-t1x9gknd 6524 4 results result NNS cord-010119-t1x9gknd 6524 5 it -PRON- PRP cord-010119-t1x9gknd 6524 6 can can MD cord-010119-t1x9gknd 6524 7 be be VB cord-010119-t1x9gknd 6524 8 concluded conclude VBN cord-010119-t1x9gknd 6524 9 that that IN cord-010119-t1x9gknd 6524 10 EDTA EDTA NNP cord-010119-t1x9gknd 6524 11 blood blood NN cord-010119-t1x9gknd 6524 12 tubes tube NNS cord-010119-t1x9gknd 6524 13 up up IN cord-010119-t1x9gknd 6524 14 to to TO cord-010119-t1x9gknd 6524 15 15 15 CD cord-010119-t1x9gknd 6524 16 days day NNS cord-010119-t1x9gknd 6524 17 post post NN cord-010119-t1x9gknd 6524 18 collection collection NN cord-010119-t1x9gknd 6524 19 can can MD cord-010119-t1x9gknd 6524 20 be be VB cord-010119-t1x9gknd 6524 21 used use VBN cord-010119-t1x9gknd 6524 22 as as IN cord-010119-t1x9gknd 6524 23 a a DT cord-010119-t1x9gknd 6524 24 source source NN cord-010119-t1x9gknd 6524 25 of of IN cord-010119-t1x9gknd 6524 26 gDNA gdna NN cord-010119-t1x9gknd 6524 27 for for IN cord-010119-t1x9gknd 6524 28 RBC RBC NNP cord-010119-t1x9gknd 6524 29 genotyping genotyping NN cord-010119-t1x9gknd 6524 30 without without IN cord-010119-t1x9gknd 6524 31 negatively negatively RB cord-010119-t1x9gknd 6524 32 effecting effect VBG cord-010119-t1x9gknd 6524 33 the the DT cord-010119-t1x9gknd 6524 34 concentration concentration NN cord-010119-t1x9gknd 6524 35 of of IN cord-010119-t1x9gknd 6524 36 the the DT cord-010119-t1x9gknd 6524 37 resulting result VBG cord-010119-t1x9gknd 6524 38 DNA dna NN cord-010119-t1x9gknd 6524 39 samples sample NNS cord-010119-t1x9gknd 6524 40 and and CC cord-010119-t1x9gknd 6524 41 the the DT cord-010119-t1x9gknd 6524 42 validity validity NN cord-010119-t1x9gknd 6524 43 of of IN cord-010119-t1x9gknd 6524 44 the the DT cord-010119-t1x9gknd 6524 45 resulting result VBG cord-010119-t1x9gknd 6524 46 genotyping genotyping NN cord-010119-t1x9gknd 6524 47 . . . cord-010119-t1x9gknd 6525 1 Case Case NNP cord-010119-t1x9gknd 6525 2 Study Study NNP cord-010119-t1x9gknd 6525 3 : : : cord-010119-t1x9gknd 6525 4 Investigation investigation NN cord-010119-t1x9gknd 6525 5 of of IN cord-010119-t1x9gknd 6525 6 Persistent Persistent NNP cord-010119-t1x9gknd 6525 7 Negative Negative NNP cord-010119-t1x9gknd 6525 8 Antibody Antibody NNP cord-010119-t1x9gknd 6525 9 Screens Screens NNPS cord-010119-t1x9gknd 6525 10 on on IN cord-010119-t1x9gknd 6525 11 Patients patient NNS cord-010119-t1x9gknd 6525 12 Receiving receive VBG cord-010119-t1x9gknd 6525 13 Daratumumab Daratumumab NNP cord-010119-t1x9gknd 6525 14 Raeann Raeann NNP cord-010119-t1x9gknd 6525 15 Thomas Thomas NNP cord-010119-t1x9gknd 6525 16 1 1 CD cord-010119-t1x9gknd 6525 17 , , , cord-010119-t1x9gknd 6525 18 Carlos Carlos NNP cord-010119-t1x9gknd 6525 19 Villa Villa NNP cord-010119-t1x9gknd 6525 20 1 1 CD cord-010119-t1x9gknd 6525 21 , , , cord-010119-t1x9gknd 6525 22 Rachel Rachel NNP cord-010119-t1x9gknd 6525 23 Davis Davis NNP cord-010119-t1x9gknd 6525 24 - - HYPH cord-010119-t1x9gknd 6525 25 Rauser Rauser NNP cord-010119-t1x9gknd 6525 26 * * NFP cord-010119-t1x9gknd 6525 27 1 1 CD cord-010119-t1x9gknd 6525 28 , , , cord-010119-t1x9gknd 6525 29 Helen Helen NNP cord-010119-t1x9gknd 6525 30 Carpenter Carpenter NNP cord-010119-t1x9gknd 6525 31 1 1 CD cord-010119-t1x9gknd 6525 32 and and CC cord-010119-t1x9gknd 6525 33 Vrunda Vrunda NNP cord-010119-t1x9gknd 6525 34 Patel Patel NNP cord-010119-t1x9gknd 6525 35 2 2 CD cord-010119-t1x9gknd 6525 36 . . . cord-010119-t1x9gknd 6525 37 1 1 CD cord-010119-t1x9gknd 6525 38 University University NNP cord-010119-t1x9gknd 6525 39 of of IN cord-010119-t1x9gknd 6525 40 Pennsylvania Pennsylvania NNP cord-010119-t1x9gknd 6525 41 , , , cord-010119-t1x9gknd 6525 42 2 2 CD cord-010119-t1x9gknd 6525 43 Hospital Hospital NNP cord-010119-t1x9gknd 6525 44 of of IN cord-010119-t1x9gknd 6525 45 the the DT cord-010119-t1x9gknd 6525 46 University University NNP cord-010119-t1x9gknd 6525 47 of of IN cord-010119-t1x9gknd 6525 48 Pennsylvania Pennsylvania NNP cord-010119-t1x9gknd 6526 1 Background Background NNP cord-010119-t1x9gknd 6526 2 / / SYM cord-010119-t1x9gknd 6526 3 Case Case NNP cord-010119-t1x9gknd 6526 4 Studies Studies NNPS cord-010119-t1x9gknd 6527 1 : : : cord-010119-t1x9gknd 6527 2 Daratumumab Daratumumab NNP cord-010119-t1x9gknd 6527 3 is be VBZ cord-010119-t1x9gknd 6527 4 an an DT cord-010119-t1x9gknd 6527 5 anti anti JJ cord-010119-t1x9gknd 6527 6 - - JJ cord-010119-t1x9gknd 6527 7 CD38 cd38 JJ cord-010119-t1x9gknd 6527 8 monoclonal monoclonal JJ cord-010119-t1x9gknd 6527 9 antibody antibody NN cord-010119-t1x9gknd 6527 10 therapy therapy NN cord-010119-t1x9gknd 6527 11 that that WDT cord-010119-t1x9gknd 6527 12 received receive VBD cord-010119-t1x9gknd 6527 13 FDA FDA NNP cord-010119-t1x9gknd 6527 14 approval approval NN cord-010119-t1x9gknd 6527 15 for for IN cord-010119-t1x9gknd 6527 16 treatment treatment NN cord-010119-t1x9gknd 6527 17 of of IN cord-010119-t1x9gknd 6527 18 multiple multiple JJ cord-010119-t1x9gknd 6527 19 myeloma myeloma NN cord-010119-t1x9gknd 6527 20 in in IN cord-010119-t1x9gknd 6527 21 2015 2015 CD cord-010119-t1x9gknd 6527 22 . . . cord-010119-t1x9gknd 6528 1 Communications communication NNS cord-010119-t1x9gknd 6528 2 suggest suggest VBP cord-010119-t1x9gknd 6528 3 all all DT cord-010119-t1x9gknd 6528 4 patients patient NNS cord-010119-t1x9gknd 6528 5 receiving receive VBG cord-010119-t1x9gknd 6528 6 therapy therapy NN cord-010119-t1x9gknd 6528 7 would would MD cord-010119-t1x9gknd 6528 8 have have VB cord-010119-t1x9gknd 6528 9 a a DT cord-010119-t1x9gknd 6528 10 positive positive JJ cord-010119-t1x9gknd 6528 11 antibody antibody NN cord-010119-t1x9gknd 6528 12 screen screen NN cord-010119-t1x9gknd 6528 13 because because IN cord-010119-t1x9gknd 6528 14 CD38 CD38 NNP cord-010119-t1x9gknd 6528 15 is be VBZ cord-010119-t1x9gknd 6528 16 a a DT cord-010119-t1x9gknd 6528 17 common common JJ cord-010119-t1x9gknd 6528 18 antigen antigen NN cord-010119-t1x9gknd 6528 19 expressed express VBN cord-010119-t1x9gknd 6528 20 on on IN cord-010119-t1x9gknd 6528 21 red red JJ cord-010119-t1x9gknd 6528 22 blood blood NN cord-010119-t1x9gknd 6528 23 cells cell NNS cord-010119-t1x9gknd 6528 24 . . . cord-010119-t1x9gknd 6529 1 Currently currently RB cord-010119-t1x9gknd 6529 2 , , , cord-010119-t1x9gknd 6529 3 154 154 CD cord-010119-t1x9gknd 6529 4 patients patient NNS cord-010119-t1x9gknd 6529 5 have have VBP cord-010119-t1x9gknd 6529 6 been be VBN cord-010119-t1x9gknd 6529 7 treated treat VBN cord-010119-t1x9gknd 6529 8 with with IN cord-010119-t1x9gknd 6529 9 daratumumab daratumumab NNP cord-010119-t1x9gknd 6529 10 at at IN cord-010119-t1x9gknd 6529 11 a a DT cord-010119-t1x9gknd 6529 12 large large JJ cord-010119-t1x9gknd 6529 13 academic academic JJ cord-010119-t1x9gknd 6529 14 medical medical JJ cord-010119-t1x9gknd 6529 15 center center NN cord-010119-t1x9gknd 6529 16 . . . cord-010119-t1x9gknd 6530 1 A a DT cord-010119-t1x9gknd 6530 2 wide wide JJ cord-010119-t1x9gknd 6530 3 variation variation NN cord-010119-t1x9gknd 6530 4 of of IN cord-010119-t1x9gknd 6530 5 reactivity reactivity NN cord-010119-t1x9gknd 6530 6 was be VBD cord-010119-t1x9gknd 6530 7 observed observe VBN cord-010119-t1x9gknd 6530 8 , , , cord-010119-t1x9gknd 6530 9 including include VBG cord-010119-t1x9gknd 6530 10 patients patient NNS cord-010119-t1x9gknd 6530 11 who who WP cord-010119-t1x9gknd 6530 12 were be VBD cord-010119-t1x9gknd 6530 13 found find VBN cord-010119-t1x9gknd 6530 14 to to TO cord-010119-t1x9gknd 6530 15 have have VB cord-010119-t1x9gknd 6530 16 consistently consistently RB cord-010119-t1x9gknd 6530 17 negative negative JJ cord-010119-t1x9gknd 6530 18 antibody antibody NN cord-010119-t1x9gknd 6530 19 screens screen NNS cord-010119-t1x9gknd 6530 20 . . . cord-010119-t1x9gknd 6531 1 While while IN cord-010119-t1x9gknd 6531 2 there there EX cord-010119-t1x9gknd 6531 3 are be VBP cord-010119-t1x9gknd 6531 4 several several JJ cord-010119-t1x9gknd 6531 5 potential potential JJ cord-010119-t1x9gknd 6531 6 causes cause NNS cord-010119-t1x9gknd 6531 7 , , , cord-010119-t1x9gknd 6531 8 neutralization neutralization NN cord-010119-t1x9gknd 6531 9 of of IN cord-010119-t1x9gknd 6531 10 anti anti JJ cord-010119-t1x9gknd 6531 11 - - JJ cord-010119-t1x9gknd 6531 12 CD38 cd38 JJ cord-010119-t1x9gknd 6531 13 antibodies antibody NNS cord-010119-t1x9gknd 6531 14 could could MD cord-010119-t1x9gknd 6531 15 easily easily RB cord-010119-t1x9gknd 6531 16 be be VB cord-010119-t1x9gknd 6531 17 tested test VBN cord-010119-t1x9gknd 6531 18 by by IN cord-010119-t1x9gknd 6531 19 applying apply VBG cord-010119-t1x9gknd 6531 20 established establish VBN cord-010119-t1x9gknd 6531 21 techniques technique NNS cord-010119-t1x9gknd 6531 22 used use VBN cord-010119-t1x9gknd 6531 23 for for IN cord-010119-t1x9gknd 6531 24 neutralizing neutralize VBG cord-010119-t1x9gknd 6531 25 antibody antibody NN cord-010119-t1x9gknd 6531 26 reactivity reactivity NN cord-010119-t1x9gknd 6531 27 . . . cord-010119-t1x9gknd 6532 1 Study Study NNP cord-010119-t1x9gknd 6532 2 Design Design NNP cord-010119-t1x9gknd 6532 3 / / SYM cord-010119-t1x9gknd 6532 4 Method method NN cord-010119-t1x9gknd 6532 5 : : : cord-010119-t1x9gknd 6533 1 Samples sample NNS cord-010119-t1x9gknd 6533 2 received receive VBN cord-010119-t1x9gknd 6533 3 were be VBD cord-010119-t1x9gknd 6533 4 drawn draw VBN cord-010119-t1x9gknd 6533 5 as as IN cord-010119-t1x9gknd 6533 6 a a DT cord-010119-t1x9gknd 6533 7 standard standard NN cord-010119-t1x9gknd 6533 8 of of IN cord-010119-t1x9gknd 6533 9 care care NN cord-010119-t1x9gknd 6533 10 . . . cord-010119-t1x9gknd 6534 1 Indirect indirect JJ cord-010119-t1x9gknd 6534 2 antiglobulin antiglobulin NN cord-010119-t1x9gknd 6534 3 testing testing NN cord-010119-t1x9gknd 6534 4 was be VBD cord-010119-t1x9gknd 6534 5 performed perform VBN cord-010119-t1x9gknd 6534 6 using use VBG cord-010119-t1x9gknd 6534 7 solid solid JJ cord-010119-t1x9gknd 6534 8 phase phase NN cord-010119-t1x9gknd 6534 9 red red JJ cord-010119-t1x9gknd 6534 10 cell cell NN cord-010119-t1x9gknd 6534 11 adherence adherence NN cord-010119-t1x9gknd 6534 12 and and CC cord-010119-t1x9gknd 6534 13 gel gel NN cord-010119-t1x9gknd 6534 14 . . . cord-010119-t1x9gknd 6535 1 Neutralization neutralization NN cord-010119-t1x9gknd 6535 2 was be VBD cord-010119-t1x9gknd 6535 3 performed perform VBN cord-010119-t1x9gknd 6535 4 by by IN cord-010119-t1x9gknd 6535 5 adding add VBG cord-010119-t1x9gknd 6535 6 equal equal JJ cord-010119-t1x9gknd 6535 7 volumes volume NNS cord-010119-t1x9gknd 6535 8 of of IN cord-010119-t1x9gknd 6535 9 negative negative JJ cord-010119-t1x9gknd 6535 10 daratumumab daratumumab NNS cord-010119-t1x9gknd 6535 11 treated treat VBN cord-010119-t1x9gknd 6535 12 patients patient NNS cord-010119-t1x9gknd 6535 13 ' ' POS cord-010119-t1x9gknd 6535 14 plasma plasma NN cord-010119-t1x9gknd 6535 15 with with IN cord-010119-t1x9gknd 6535 16 positive positive JJ cord-010119-t1x9gknd 6535 17 daratumumab daratumumab NNS cord-010119-t1x9gknd 6535 18 treated treat VBN cord-010119-t1x9gknd 6535 19 patients patient NNS cord-010119-t1x9gknd 6535 20 ' ' POS cord-010119-t1x9gknd 6535 21 plasma plasma NN cord-010119-t1x9gknd 6535 22 . . . cord-010119-t1x9gknd 6536 1 A a DT cord-010119-t1x9gknd 6536 2 dilution dilution NN cord-010119-t1x9gknd 6536 3 control control NN cord-010119-t1x9gknd 6536 4 was be VBD cord-010119-t1x9gknd 6536 5 made make VBN cord-010119-t1x9gknd 6536 6 by by IN cord-010119-t1x9gknd 6536 7 adding add VBG cord-010119-t1x9gknd 6536 8 saline saline NN cord-010119-t1x9gknd 6536 9 to to IN cord-010119-t1x9gknd 6536 10 each each DT cord-010119-t1x9gknd 6536 11 positive positive JJ cord-010119-t1x9gknd 6536 12 patient patient NN cord-010119-t1x9gknd 6536 13 's 's POS cord-010119-t1x9gknd 6536 14 plasma plasma NN cord-010119-t1x9gknd 6536 15 . . . cord-010119-t1x9gknd 6537 1 Samples sample NNS cord-010119-t1x9gknd 6537 2 were be VBD cord-010119-t1x9gknd 6537 3 incubated incubate VBN cord-010119-t1x9gknd 6537 4 for for IN cord-010119-t1x9gknd 6537 5 1 1 CD cord-010119-t1x9gknd 6537 6 hour hour NN cord-010119-t1x9gknd 6537 7 at at IN cord-010119-t1x9gknd 6537 8 room room NN cord-010119-t1x9gknd 6537 9 temperature temperature NN cord-010119-t1x9gknd 6537 10 and and CC cord-010119-t1x9gknd 6537 11 antibody antibody NN cord-010119-t1x9gknd 6537 12 screens screen NNS cord-010119-t1x9gknd 6537 13 were be VBD cord-010119-t1x9gknd 6537 14 repeated repeat VBN cord-010119-t1x9gknd 6537 15 . . . cord-010119-t1x9gknd 6538 1 Serial serial JJ cord-010119-t1x9gknd 6538 2 two two CD cord-010119-t1x9gknd 6538 3 - - HYPH cord-010119-t1x9gknd 6538 4 fold fold NN cord-010119-t1x9gknd 6538 5 dilutions dilution NNS cord-010119-t1x9gknd 6538 6 were be VBD cord-010119-t1x9gknd 6538 7 also also RB cord-010119-t1x9gknd 6538 8 tested test VBN cord-010119-t1x9gknd 6538 9 to to TO cord-010119-t1x9gknd 6538 10 determine determine VB cord-010119-t1x9gknd 6538 11 if if IN cord-010119-t1x9gknd 6538 12 the the DT cord-010119-t1x9gknd 6538 13 neutralization neutralization NN cord-010119-t1x9gknd 6538 14 could could MD cord-010119-t1x9gknd 6538 15 be be VB cord-010119-t1x9gknd 6538 16 titered titere VBN cord-010119-t1x9gknd 6538 17 . . . cord-010119-t1x9gknd 6539 1 Testing testing NN cord-010119-t1x9gknd 6539 2 was be VBD cord-010119-t1x9gknd 6539 3 repeated repeat VBN cord-010119-t1x9gknd 6539 4 using use VBG cord-010119-t1x9gknd 6539 5 various various JJ cord-010119-t1x9gknd 6539 6 positive positive JJ cord-010119-t1x9gknd 6539 7 patient patient NN cord-010119-t1x9gknd 6539 8 samples sample NNS cord-010119-t1x9gknd 6539 9 to to TO cord-010119-t1x9gknd 6539 10 determine determine VB cord-010119-t1x9gknd 6539 11 if if IN cord-010119-t1x9gknd 6539 12 negative negative JJ cord-010119-t1x9gknd 6539 13 / / SYM cord-010119-t1x9gknd 6539 14 positive positive JJ cord-010119-t1x9gknd 6539 15 combinations combination NNS cord-010119-t1x9gknd 6539 16 resulted result VBD cord-010119-t1x9gknd 6539 17 in in IN cord-010119-t1x9gknd 6539 18 different different JJ cord-010119-t1x9gknd 6539 19 reactivity reactivity NN cord-010119-t1x9gknd 6539 20 . . . cord-010119-t1x9gknd 6540 1 Results/ Results/ . cord-010119-t1x9gknd 6541 1 Finding find VBG cord-010119-t1x9gknd 6541 2 : : : cord-010119-t1x9gknd 6541 3 All all DT cord-010119-t1x9gknd 6541 4 control control NN cord-010119-t1x9gknd 6541 5 samples sample NNS cord-010119-t1x9gknd 6541 6 remained remain VBD cord-010119-t1x9gknd 6541 7 positive positive JJ cord-010119-t1x9gknd 6541 8 . . . cord-010119-t1x9gknd 6542 1 Positive positive JJ cord-010119-t1x9gknd 6542 2 / / SYM cord-010119-t1x9gknd 6542 3 negative negative JJ cord-010119-t1x9gknd 6542 4 samples sample NNS cord-010119-t1x9gknd 6542 5 were be VBD cord-010119-t1x9gknd 6542 6 negative negative JJ cord-010119-t1x9gknd 6542 7 in in IN cord-010119-t1x9gknd 6542 8 solid solid JJ cord-010119-t1x9gknd 6542 9 phase phase NN cord-010119-t1x9gknd 6542 10 testing test VBG cord-010119-t1x9gknd 6542 11 across across IN cord-010119-t1x9gknd 6542 12 all all DT cord-010119-t1x9gknd 6542 13 patient patient JJ cord-010119-t1x9gknd 6542 14 combinations combination NNS cord-010119-t1x9gknd 6542 15 at at IN cord-010119-t1x9gknd 6542 16 1:1 1:1 CD cord-010119-t1x9gknd 6542 17 dilutions dilution NNS cord-010119-t1x9gknd 6542 18 . . . cord-010119-t1x9gknd 6543 1 Variable variable JJ cord-010119-t1x9gknd 6543 2 reactivity reactivity NN cord-010119-t1x9gknd 6543 3 was be VBD cord-010119-t1x9gknd 6543 4 observed observe VBN cord-010119-t1x9gknd 6543 5 in in IN cord-010119-t1x9gknd 6543 6 gel gel NN cord-010119-t1x9gknd 6543 7 . . . cord-010119-t1x9gknd 6544 1 Serial serial JJ cord-010119-t1x9gknd 6544 2 dilutions dilution NNS cord-010119-t1x9gknd 6544 3 showed show VBD cord-010119-t1x9gknd 6544 4 that that IN cord-010119-t1x9gknd 6544 5 neutralization neutralization NN cord-010119-t1x9gknd 6544 6 for for IN cord-010119-t1x9gknd 6544 7 2 2 CD cord-010119-t1x9gknd 6544 8 negative negative JJ cord-010119-t1x9gknd 6544 9 patients patient NNS cord-010119-t1x9gknd 6544 10 was be VBD cord-010119-t1x9gknd 6544 11 observed observe VBN cord-010119-t1x9gknd 6544 12 up up RP cord-010119-t1x9gknd 6544 13 to to IN cord-010119-t1x9gknd 6544 14 a a DT cord-010119-t1x9gknd 6544 15 1:4 1:4 CD cord-010119-t1x9gknd 6544 16 dilution dilution NN cord-010119-t1x9gknd 6544 17 . . . cord-010119-t1x9gknd 6545 1 Conclusion conclusion NN cord-010119-t1x9gknd 6545 2 : : : cord-010119-t1x9gknd 6546 1 Results result NNS cord-010119-t1x9gknd 6546 2 suggest suggest VBP cord-010119-t1x9gknd 6546 3 that that IN cord-010119-t1x9gknd 6546 4 patients patient NNS cord-010119-t1x9gknd 6546 5 ' ' POS cord-010119-t1x9gknd 6546 6 plasma plasma NN cord-010119-t1x9gknd 6546 7 may may MD cord-010119-t1x9gknd 6546 8 have have VB cord-010119-t1x9gknd 6546 9 a a DT cord-010119-t1x9gknd 6546 10 substance substance NN cord-010119-t1x9gknd 6546 11 that that WDT cord-010119-t1x9gknd 6546 12 neutralizes neutralize VBZ cord-010119-t1x9gknd 6546 13 the the DT cord-010119-t1x9gknd 6546 14 antibodies antibody NNS cord-010119-t1x9gknd 6546 15 . . . cord-010119-t1x9gknd 6547 1 There there EX cord-010119-t1x9gknd 6547 2 is be VBZ cord-010119-t1x9gknd 6547 3 a a DT cord-010119-t1x9gknd 6547 4 possible possible JJ cord-010119-t1x9gknd 6547 5 correlation correlation NN cord-010119-t1x9gknd 6547 6 with with IN cord-010119-t1x9gknd 6547 7 patients patient NNS cord-010119-t1x9gknd 6547 8 who who WP cord-010119-t1x9gknd 6547 9 have have VBP cord-010119-t1x9gknd 6547 10 persistent persistent JJ cord-010119-t1x9gknd 6547 11 negative negative JJ cord-010119-t1x9gknd 6547 12 antibody antibody NN cord-010119-t1x9gknd 6547 13 screens screen NNS cord-010119-t1x9gknd 6547 14 and and CC cord-010119-t1x9gknd 6547 15 patient patient JJ cord-010119-t1x9gknd 6547 16 response response NN cord-010119-t1x9gknd 6547 17 to to IN cord-010119-t1x9gknd 6547 18 daratumumab daratumumab NNP cord-010119-t1x9gknd 6547 19 . . . cord-010119-t1x9gknd 6548 1 Additional additional JJ cord-010119-t1x9gknd 6548 2 studies study NNS cord-010119-t1x9gknd 6548 3 are be VBP cord-010119-t1x9gknd 6548 4 necessary necessary JJ cord-010119-t1x9gknd 6548 5 to to TO cord-010119-t1x9gknd 6548 6 uncover uncover VB cord-010119-t1x9gknd 6548 7 how how WRB cord-010119-t1x9gknd 6548 8 this this DT cord-010119-t1x9gknd 6548 9 correlates correlate VBZ cord-010119-t1x9gknd 6548 10 to to IN cord-010119-t1x9gknd 6548 11 patient patient JJ cord-010119-t1x9gknd 6548 12 outcomes outcome NNS cord-010119-t1x9gknd 6548 13 . . . cord-010119-t1x9gknd 6549 1 Further further JJ cord-010119-t1x9gknd 6549 2 studies study NNS cord-010119-t1x9gknd 6549 3 using use VBG cord-010119-t1x9gknd 6549 4 a a DT cord-010119-t1x9gknd 6549 5 standardized standardized JJ cord-010119-t1x9gknd 6549 6 daratumumabspiked daratumumabspiked JJ cord-010119-t1x9gknd 6549 7 sample sample NN cord-010119-t1x9gknd 6549 8 will will MD cord-010119-t1x9gknd 6549 9 be be VB cord-010119-t1x9gknd 6549 10 conducted conduct VBN cord-010119-t1x9gknd 6549 11 . . . cord-010119-t1x9gknd 6550 1 Background Background NNP cord-010119-t1x9gknd 6550 2 / / SYM cord-010119-t1x9gknd 6550 3 Case Case NNP cord-010119-t1x9gknd 6550 4 Studies Studies NNPS cord-010119-t1x9gknd 6550 5 : : : cord-010119-t1x9gknd 6550 6 The the DT cord-010119-t1x9gknd 6550 7 MNS MNS NNP cord-010119-t1x9gknd 6550 8 blood blood NN cord-010119-t1x9gknd 6550 9 group group NN cord-010119-t1x9gknd 6550 10 is be VBZ cord-010119-t1x9gknd 6550 11 a a DT cord-010119-t1x9gknd 6550 12 red red JJ cord-010119-t1x9gknd 6550 13 cell cell NN cord-010119-t1x9gknd 6550 14 antigen antigen NN cord-010119-t1x9gknd 6550 15 system system NN cord-010119-t1x9gknd 6550 16 located locate VBN cord-010119-t1x9gknd 6550 17 on on IN cord-010119-t1x9gknd 6550 18 glycophorin glycophorin NNP cord-010119-t1x9gknd 6550 19 A A NNP cord-010119-t1x9gknd 6550 20 ( ( -LRB- cord-010119-t1x9gknd 6550 21 GYPA GYPA NNP cord-010119-t1x9gknd 6550 22 ) ) -RRB- cord-010119-t1x9gknd 6550 23 and and CC cord-010119-t1x9gknd 6550 24 glycophorin glycophorin NNP cord-010119-t1x9gknd 6550 25 B B NNP cord-010119-t1x9gknd 6550 26 ( ( -LRB- cord-010119-t1x9gknd 6550 27 GYPB GYPB NNP cord-010119-t1x9gknd 6550 28 ) ) -RRB- cord-010119-t1x9gknd 6550 29 . . . cord-010119-t1x9gknd 6551 1 Individuals individual NNS cord-010119-t1x9gknd 6551 2 lacking lack VBG cord-010119-t1x9gknd 6551 3 GYPA GYPA NNP cord-010119-t1x9gknd 6551 4 or or CC cord-010119-t1x9gknd 6551 5 both both CC cord-010119-t1x9gknd 6551 6 GYPA GYPA NNP cord-010119-t1x9gknd 6551 7 and and CC cord-010119-t1x9gknd 6551 8 GYPB GYPB NNP cord-010119-t1x9gknd 6551 9 on on IN cord-010119-t1x9gknd 6551 10 their -PRON- PRP$ cord-010119-t1x9gknd 6551 11 red red JJ cord-010119-t1x9gknd 6551 12 blood blood NN cord-010119-t1x9gknd 6551 13 cells cell NNS cord-010119-t1x9gknd 6551 14 may may MD cord-010119-t1x9gknd 6551 15 develop develop VB cord-010119-t1x9gknd 6551 16 a a DT cord-010119-t1x9gknd 6551 17 rare rare JJ cord-010119-t1x9gknd 6551 18 antibody antibody NN cord-010119-t1x9gknd 6551 19 against against IN cord-010119-t1x9gknd 6551 20 the the DT cord-010119-t1x9gknd 6551 21 En En NNP cord-010119-t1x9gknd 6551 22 ( ( -LRB- cord-010119-t1x9gknd 6551 23 a a DT cord-010119-t1x9gknd 6551 24 ) ) -RRB- cord-010119-t1x9gknd 6551 25 antigen antigen NN cord-010119-t1x9gknd 6551 26 . . . cord-010119-t1x9gknd 6552 1 The the DT cord-010119-t1x9gknd 6552 2 En En NNP cord-010119-t1x9gknd 6552 3 ( ( -LRB- cord-010119-t1x9gknd 6552 4 a a DT cord-010119-t1x9gknd 6552 5 ) ) -RRB- cord-010119-t1x9gknd 6552 6 antigen antigen NN cord-010119-t1x9gknd 6552 7 is be VBZ cord-010119-t1x9gknd 6552 8 a a DT cord-010119-t1x9gknd 6552 9 highprevalence highprevalence NN cord-010119-t1x9gknd 6552 10 antigen antigen NN cord-010119-t1x9gknd 6552 11 , , , cord-010119-t1x9gknd 6552 12 located locate VBN cord-010119-t1x9gknd 6552 13 on on IN cord-010119-t1x9gknd 6552 14 GYPA GYPA NNP cord-010119-t1x9gknd 6552 15 . . . cord-010119-t1x9gknd 6553 1 We -PRON- PRP cord-010119-t1x9gknd 6553 2 present present VBP cord-010119-t1x9gknd 6553 3 a a DT cord-010119-t1x9gknd 6553 4 case case NN cord-010119-t1x9gknd 6553 5 with with IN cord-010119-t1x9gknd 6553 6 a a DT cord-010119-t1x9gknd 6553 7 rare rare JJ cord-010119-t1x9gknd 6553 8 red red JJ cord-010119-t1x9gknd 6553 9 cell cell NN cord-010119-t1x9gknd 6553 10 phenotype phenotype NN cord-010119-t1x9gknd 6553 11 and and CC cord-010119-t1x9gknd 6553 12 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6553 13 to to IN cord-010119-t1x9gknd 6553 14 the the DT cord-010119-t1x9gknd 6553 15 En En NNP cord-010119-t1x9gknd 6553 16 ( ( -LRB- cord-010119-t1x9gknd 6553 17 a a DT cord-010119-t1x9gknd 6553 18 ) ) -RRB- cord-010119-t1x9gknd 6553 19 antigen antigen NN cord-010119-t1x9gknd 6553 20 . . . cord-010119-t1x9gknd 6554 1 A a DT cord-010119-t1x9gknd 6554 2 28 28 CD cord-010119-t1x9gknd 6554 3 y y NN cord-010119-t1x9gknd 6554 4 / / SYM cord-010119-t1x9gknd 6554 5 o o NN cord-010119-t1x9gknd 6554 6 G1P0 G1P0 NNP cord-010119-t1x9gknd 6554 7 at at IN cord-010119-t1x9gknd 6555 1 approximately approximately RB cord-010119-t1x9gknd 6555 2 23 23 CD cord-010119-t1x9gknd 6555 3 weeks week NNS cord-010119-t1x9gknd 6555 4 gestation gestation NN cord-010119-t1x9gknd 6555 5 was be VBD cord-010119-t1x9gknd 6555 6 discovered discover VBN cord-010119-t1x9gknd 6555 7 to to TO cord-010119-t1x9gknd 6555 8 have have VB cord-010119-t1x9gknd 6555 9 an an DT cord-010119-t1x9gknd 6555 10 anti anti JJ cord-010119-t1x9gknd 6555 11 - - JJ cord-010119-t1x9gknd 6555 12 En en JJ cord-010119-t1x9gknd 6555 13 ( ( -LRB- cord-010119-t1x9gknd 6555 14 a a DT cord-010119-t1x9gknd 6555 15 ) ) -RRB- cord-010119-t1x9gknd 6555 16 antibody antibody NN cord-010119-t1x9gknd 6555 17 in in IN cord-010119-t1x9gknd 6555 18 her -PRON- PRP$ cord-010119-t1x9gknd 6555 19 plasma plasma NN cord-010119-t1x9gknd 6555 20 on on IN cord-010119-t1x9gknd 6555 21 a a DT cord-010119-t1x9gknd 6555 22 prenatal prenatal JJ cord-010119-t1x9gknd 6555 23 type type NN cord-010119-t1x9gknd 6555 24 and and CC cord-010119-t1x9gknd 6555 25 screen screen NN cord-010119-t1x9gknd 6555 26 . . . cord-010119-t1x9gknd 6556 1 This this DT cord-010119-t1x9gknd 6556 2 was be VBD cord-010119-t1x9gknd 6556 3 worrisome worrisome JJ cord-010119-t1x9gknd 6556 4 for for IN cord-010119-t1x9gknd 6556 5 both both DT cord-010119-t1x9gknd 6556 6 mother mother NN cord-010119-t1x9gknd 6556 7 and and CC cord-010119-t1x9gknd 6556 8 fetus fetus NN cord-010119-t1x9gknd 6556 9 , , , cord-010119-t1x9gknd 6556 10 as as IN cord-010119-t1x9gknd 6556 11 the the DT cord-010119-t1x9gknd 6556 12 En En NNP cord-010119-t1x9gknd 6556 13 ( ( -LRB- cord-010119-t1x9gknd 6556 14 a a DT cord-010119-t1x9gknd 6556 15 ) ) -RRB- cord-010119-t1x9gknd 6556 16 antibody antibody NN cord-010119-t1x9gknd 6556 17 is be VBZ cord-010119-t1x9gknd 6556 18 of of IN cord-010119-t1x9gknd 6556 19 IgG igg NN cord-010119-t1x9gknd 6556 20 isotype isotype NN cord-010119-t1x9gknd 6556 21 and and CC cord-010119-t1x9gknd 6556 22 has have VBZ cord-010119-t1x9gknd 6556 23 been be VBN cord-010119-t1x9gknd 6556 24 implicated implicate VBN cord-010119-t1x9gknd 6556 25 in in IN cord-010119-t1x9gknd 6556 26 both both DT cord-010119-t1x9gknd 6556 27 acute acute JJ cord-010119-t1x9gknd 6556 28 and and CC cord-010119-t1x9gknd 6556 29 delayed delayed JJ cord-010119-t1x9gknd 6556 30 hemolytic hemolytic JJ cord-010119-t1x9gknd 6556 31 transfusion transfusion NN cord-010119-t1x9gknd 6556 32 reactions reaction NNS cord-010119-t1x9gknd 6556 33 and and CC cord-010119-t1x9gknd 6556 34 hemolytic hemolytic JJ cord-010119-t1x9gknd 6556 35 disease disease NN cord-010119-t1x9gknd 6556 36 of of IN cord-010119-t1x9gknd 6556 37 the the DT cord-010119-t1x9gknd 6556 38 fetus fetus NN cord-010119-t1x9gknd 6556 39 and and CC cord-010119-t1x9gknd 6556 40 newborn newborn JJ cord-010119-t1x9gknd 6556 41 ( ( -LRB- cord-010119-t1x9gknd 6556 42 HDFN HDFN NNP cord-010119-t1x9gknd 6556 43 ) ) -RRB- cord-010119-t1x9gknd 6556 44 [ [ -LRB- cord-010119-t1x9gknd 6556 45 1 1 CD cord-010119-t1x9gknd 6556 46 , , , cord-010119-t1x9gknd 6556 47 2 2 CD cord-010119-t1x9gknd 6556 48 ] ] -RRB- cord-010119-t1x9gknd 6556 49 . . . cord-010119-t1x9gknd 6557 1 Further further RB cord-010119-t1x9gknd 6557 2 testing testing NN cord-010119-t1x9gknd 6557 3 with with IN cord-010119-t1x9gknd 6557 4 red red JJ cord-010119-t1x9gknd 6557 5 cell cell NN cord-010119-t1x9gknd 6557 6 antisera antisera NNP cord-010119-t1x9gknd 6557 7 revealed reveal VBD cord-010119-t1x9gknd 6557 8 that that IN cord-010119-t1x9gknd 6557 9 the the DT cord-010119-t1x9gknd 6557 10 patient patient NN cord-010119-t1x9gknd 6557 11 lacked lack VBD cord-010119-t1x9gknd 6557 12 M M NNP cord-010119-t1x9gknd 6557 13 , , , cord-010119-t1x9gknd 6557 14 N N NNP cord-010119-t1x9gknd 6557 15 , , , cord-010119-t1x9gknd 6557 16 S S NNP cord-010119-t1x9gknd 6557 17 , , , cord-010119-t1x9gknd 6557 18 s s NNP cord-010119-t1x9gknd 6557 19 , , , cord-010119-t1x9gknd 6557 20 and and CC cord-010119-t1x9gknd 6557 21 U U NNP cord-010119-t1x9gknd 6557 22 antigens antigen NNS cord-010119-t1x9gknd 6557 23 . . . cord-010119-t1x9gknd 6558 1 A a DT cord-010119-t1x9gknd 6558 2 multiplex multiplex NN cord-010119-t1x9gknd 6558 3 , , , cord-010119-t1x9gknd 6558 4 allele allele NN cord-010119-t1x9gknd 6558 5 - - HYPH cord-010119-t1x9gknd 6558 6 specific specific JJ cord-010119-t1x9gknd 6558 7 , , , cord-010119-t1x9gknd 6558 8 PCR PCR NNP cord-010119-t1x9gknd 6558 9 platform platform NN cord-010119-t1x9gknd 6558 10 we -PRON- PRP cord-010119-t1x9gknd 6558 11 commonly commonly RB cord-010119-t1x9gknd 6558 12 use use VBP cord-010119-t1x9gknd 6558 13 to to TO cord-010119-t1x9gknd 6558 14 detect detect VB cord-010119-t1x9gknd 6558 15 the the DT cord-010119-t1x9gknd 6558 16 presence presence NN cord-010119-t1x9gknd 6558 17 or or CC cord-010119-t1x9gknd 6558 18 absence absence NN cord-010119-t1x9gknd 6558 19 of of IN cord-010119-t1x9gknd 6558 20 red red JJ cord-010119-t1x9gknd 6558 21 cell cell NN cord-010119-t1x9gknd 6558 22 gene gene NN cord-010119-t1x9gknd 6558 23 sequences sequence NNS cord-010119-t1x9gknd 6558 24 failed fail VBD cord-010119-t1x9gknd 6558 25 to to TO cord-010119-t1x9gknd 6558 26 amplify amplify VB cord-010119-t1x9gknd 6558 27 genes gene NNS cord-010119-t1x9gknd 6558 28 specific specific JJ cord-010119-t1x9gknd 6558 29 for for IN cord-010119-t1x9gknd 6558 30 the the DT cord-010119-t1x9gknd 6558 31 M M NNP cord-010119-t1x9gknd 6558 32 , , , cord-010119-t1x9gknd 6558 33 N N NNP cord-010119-t1x9gknd 6558 34 , , , cord-010119-t1x9gknd 6558 35 S S NNP cord-010119-t1x9gknd 6558 36 , , , cord-010119-t1x9gknd 6558 37 s s NNP cord-010119-t1x9gknd 6558 38 , , , cord-010119-t1x9gknd 6558 39 and and CC cord-010119-t1x9gknd 6558 40 U U NNP cord-010119-t1x9gknd 6558 41 antigens antigen NNS cord-010119-t1x9gknd 6558 42 . . . cord-010119-t1x9gknd 6559 1 These these DT cord-010119-t1x9gknd 6559 2 findings finding NNS cord-010119-t1x9gknd 6559 3 were be VBD cord-010119-t1x9gknd 6559 4 consistent consistent JJ cord-010119-t1x9gknd 6559 5 with with IN cord-010119-t1x9gknd 6559 6 a a DT cord-010119-t1x9gknd 6559 7 null null JJ cord-010119-t1x9gknd 6559 8 phenotype phenotype NN cord-010119-t1x9gknd 6559 9 for for IN cord-010119-t1x9gknd 6559 10 both both CC cord-010119-t1x9gknd 6559 11 GYPA GYPA NNP cord-010119-t1x9gknd 6559 12 and and CC cord-010119-t1x9gknd 6559 13 GYPB gypb NN cord-010119-t1x9gknd 6559 14 antigens antigen NNS cord-010119-t1x9gknd 6559 15 , , , cord-010119-t1x9gknd 6559 16 i.e. i.e. FW cord-010119-t1x9gknd 6559 17 M M NNP cord-010119-t1x9gknd 6559 18 ( ( -LRB- cord-010119-t1x9gknd 6559 19 k k NNP cord-010119-t1x9gknd 6559 20 ) ) -RRB- cord-010119-t1x9gknd 6559 21 M M NNP cord-010119-t1x9gknd 6559 22 ( ( -LRB- cord-010119-t1x9gknd 6559 23 k k NNP cord-010119-t1x9gknd 6559 24 ) ) -RRB- cord-010119-t1x9gknd 6559 25 phenotype phenotype NN cord-010119-t1x9gknd 6559 26 . . . cord-010119-t1x9gknd 6560 1 The the DT cord-010119-t1x9gknd 6560 2 patient patient NN cord-010119-t1x9gknd 6560 3 's 's POS cord-010119-t1x9gknd 6560 4 husband husband NN cord-010119-t1x9gknd 6560 5 and and CC cord-010119-t1x9gknd 6560 6 father father NN cord-010119-t1x9gknd 6560 7 of of IN cord-010119-t1x9gknd 6560 8 her -PRON- PRP$ cord-010119-t1x9gknd 6560 9 unborn unborn JJ cord-010119-t1x9gknd 6560 10 baby baby NN cord-010119-t1x9gknd 6560 11 demonstrated demonstrate VBD cord-010119-t1x9gknd 6560 12 a a DT cord-010119-t1x9gknd 6560 13 M1N m1n NN cord-010119-t1x9gknd 6560 14 - - HYPH cord-010119-t1x9gknd 6560 15 S1s1 S1s1 NNP cord-010119-t1x9gknd 6560 16 phenotype phenotype NN cord-010119-t1x9gknd 6560 17 by by IN cord-010119-t1x9gknd 6560 18 the the DT cord-010119-t1x9gknd 6560 19 same same JJ cord-010119-t1x9gknd 6560 20 serological serological JJ cord-010119-t1x9gknd 6560 21 and and CC cord-010119-t1x9gknd 6560 22 molecular molecular JJ cord-010119-t1x9gknd 6560 23 means mean NNS cord-010119-t1x9gknd 6560 24 . . . cord-010119-t1x9gknd 6561 1 Given give VBN cord-010119-t1x9gknd 6561 2 the the DT cord-010119-t1x9gknd 6561 3 exceedingly exceedingly RB cord-010119-t1x9gknd 6561 4 rare rare JJ cord-010119-t1x9gknd 6561 5 incidence incidence NN cord-010119-t1x9gknd 6561 6 of of IN cord-010119-t1x9gknd 6561 7 En En NNP cord-010119-t1x9gknd 6561 8 ( ( -LRB- cord-010119-t1x9gknd 6561 9 a- a- NN cord-010119-t1x9gknd 6561 10 ) ) -RRB- cord-010119-t1x9gknd 6561 11 individuals individual NNS cord-010119-t1x9gknd 6561 12 ( ( -LRB- cord-010119-t1x9gknd 6561 13 positive positive JJ cord-010119-t1x9gknd 6561 14 frequency frequency NN cord-010119-t1x9gknd 6561 15 > > XX cord-010119-t1x9gknd 6561 16 99.9 99.9 CD cord-010119-t1x9gknd 6561 17 ) ) -RRB- cord-010119-t1x9gknd 6561 18 , , , cord-010119-t1x9gknd 6561 19 clinical clinical JJ cord-010119-t1x9gknd 6561 20 encounters encounter NNS cord-010119-t1x9gknd 6561 21 with with IN cord-010119-t1x9gknd 6561 22 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6561 23 to to IN cord-010119-t1x9gknd 6561 24 this this DT cord-010119-t1x9gknd 6561 25 antigen antigen NN cord-010119-t1x9gknd 6561 26 are be VBP cord-010119-t1x9gknd 6561 27 limited limit VBN cord-010119-t1x9gknd 6561 28 in in IN cord-010119-t1x9gknd 6561 29 our -PRON- PRP$ cord-010119-t1x9gknd 6561 30 experience experience NN cord-010119-t1x9gknd 6561 31 and and CC cord-010119-t1x9gknd 6561 32 in in IN cord-010119-t1x9gknd 6561 33 the the DT cord-010119-t1x9gknd 6561 34 literature literature NN cord-010119-t1x9gknd 6561 35 [ [ -LRB- cord-010119-t1x9gknd 6561 36 1 1 CD cord-010119-t1x9gknd 6561 37 , , , cord-010119-t1x9gknd 6561 38 2 2 CD cord-010119-t1x9gknd 6561 39 ] ] -RRB- cord-010119-t1x9gknd 6561 40 . . . cord-010119-t1x9gknd 6562 1 However however RB cord-010119-t1x9gknd 6562 2 , , , cord-010119-t1x9gknd 6562 3 the the DT cord-010119-t1x9gknd 6562 4 existing exist VBG cord-010119-t1x9gknd 6562 5 data datum NNS cord-010119-t1x9gknd 6562 6 gives give VBZ cord-010119-t1x9gknd 6562 7 credence credence NN cord-010119-t1x9gknd 6562 8 to to IN cord-010119-t1x9gknd 6562 9 its -PRON- PRP$ cord-010119-t1x9gknd 6562 10 association association NN cord-010119-t1x9gknd 6562 11 with with IN cord-010119-t1x9gknd 6562 12 transfusion transfusion NN cord-010119-t1x9gknd 6562 13 reactions reaction NNS cord-010119-t1x9gknd 6562 14 and and CC cord-010119-t1x9gknd 6562 15 hemolytic hemolytic JJ cord-010119-t1x9gknd 6562 16 disease disease NN cord-010119-t1x9gknd 6562 17 of of IN cord-010119-t1x9gknd 6562 18 the the DT cord-010119-t1x9gknd 6562 19 fetus fetus NN cord-010119-t1x9gknd 6562 20 and and CC cord-010119-t1x9gknd 6562 21 newborn newborn JJ cord-010119-t1x9gknd 6562 22 ( ( -LRB- cord-010119-t1x9gknd 6562 23 HDFN HDFN NNP cord-010119-t1x9gknd 6562 24 ) ) -RRB- cord-010119-t1x9gknd 6562 25 . . . cord-010119-t1x9gknd 6563 1 The the DT cord-010119-t1x9gknd 6563 2 consensus consensus NN cord-010119-t1x9gknd 6563 3 in in IN cord-010119-t1x9gknd 6563 4 this this DT cord-010119-t1x9gknd 6563 5 case case NN cord-010119-t1x9gknd 6563 6 was be VBD cord-010119-t1x9gknd 6563 7 to to TO cord-010119-t1x9gknd 6563 8 work work VB cord-010119-t1x9gknd 6563 9 her -PRON- PRP cord-010119-t1x9gknd 6563 10 up up RP cord-010119-t1x9gknd 6563 11 as as IN cord-010119-t1x9gknd 6563 12 a a DT cord-010119-t1x9gknd 6563 13 high high JJ cord-010119-t1x9gknd 6563 14 - - HYPH cord-010119-t1x9gknd 6563 15 risk risk NN cord-010119-t1x9gknd 6563 16 pregnancy pregnancy NN cord-010119-t1x9gknd 6563 17 with with IN cord-010119-t1x9gknd 6563 18 frequent frequent JJ cord-010119-t1x9gknd 6563 19 intensive intensive JJ cord-010119-t1x9gknd 6563 20 monitoring monitoring NN cord-010119-t1x9gknd 6563 21 which which WDT cord-010119-t1x9gknd 6563 22 involved involve VBD cord-010119-t1x9gknd 6563 23 frequent frequent JJ cord-010119-t1x9gknd 6563 24 monitoring monitoring NN cord-010119-t1x9gknd 6563 25 of of IN cord-010119-t1x9gknd 6563 26 antibody antibody NN cord-010119-t1x9gknd 6563 27 titers titer NNS cord-010119-t1x9gknd 6563 28 . . . cord-010119-t1x9gknd 6564 1 If if IN cord-010119-t1x9gknd 6564 2 transfusions transfusion NNS cord-010119-t1x9gknd 6564 3 were be VBD cord-010119-t1x9gknd 6564 4 required require VBN cord-010119-t1x9gknd 6564 5 for for IN cord-010119-t1x9gknd 6564 6 the the DT cord-010119-t1x9gknd 6564 7 mother mother NN cord-010119-t1x9gknd 6564 8 or or CC cord-010119-t1x9gknd 6564 9 fetus fetus NN cord-010119-t1x9gknd 6564 10 , , , cord-010119-t1x9gknd 6564 11 our -PRON- PRP$ cord-010119-t1x9gknd 6564 12 options option NNS cord-010119-t1x9gknd 6564 13 were be VBD cord-010119-t1x9gknd 6564 14 to to TO cord-010119-t1x9gknd 6564 15 either either DT cord-010119-t1x9gknd 6564 16 search search VB cord-010119-t1x9gknd 6564 17 for for IN cord-010119-t1x9gknd 6564 18 rare rare JJ cord-010119-t1x9gknd 6564 19 units unit NNS cord-010119-t1x9gknd 6564 20 lacking lack VBG cord-010119-t1x9gknd 6564 21 the the DT cord-010119-t1x9gknd 6564 22 En(a En(a NNP cord-010119-t1x9gknd 6564 23 ) ) -RRB- cord-010119-t1x9gknd 6564 24 antigen antigen NN cord-010119-t1x9gknd 6564 25 via via IN cord-010119-t1x9gknd 6564 26 rare rare JJ cord-010119-t1x9gknd 6564 27 blood blood NN cord-010119-t1x9gknd 6564 28 donor donor NN cord-010119-t1x9gknd 6564 29 registries registry NNS cord-010119-t1x9gknd 6564 30 or or CC cord-010119-t1x9gknd 6564 31 directed direct VBN cord-010119-t1x9gknd 6564 32 donations donation NNS cord-010119-t1x9gknd 6564 33 from from IN cord-010119-t1x9gknd 6564 34 family family NN cord-010119-t1x9gknd 6564 35 members member NNS cord-010119-t1x9gknd 6564 36 who who WP cord-010119-t1x9gknd 6564 37 match match VBP cord-010119-t1x9gknd 6564 38 the the DT cord-010119-t1x9gknd 6564 39 patient patient NN cord-010119-t1x9gknd 6564 40 's 's POS cord-010119-t1x9gknd 6564 41 phenotype phenotype NN cord-010119-t1x9gknd 6564 42 . . . cord-010119-t1x9gknd 6565 1 At at IN cord-010119-t1x9gknd 6565 2 term term NN cord-010119-t1x9gknd 6565 3 , , , cord-010119-t1x9gknd 6565 4 the the DT cord-010119-t1x9gknd 6565 5 patient patient NN cord-010119-t1x9gknd 6565 6 underwent undergo VBD cord-010119-t1x9gknd 6565 7 induction induction NN cord-010119-t1x9gknd 6565 8 of of IN cord-010119-t1x9gknd 6565 9 labor labor NN cord-010119-t1x9gknd 6565 10 and and CC cord-010119-t1x9gknd 6565 11 successfully successfully RB cord-010119-t1x9gknd 6565 12 delivered deliver VBD cord-010119-t1x9gknd 6565 13 a a DT cord-010119-t1x9gknd 6565 14 health health NN cord-010119-t1x9gknd 6565 15 baby baby NN cord-010119-t1x9gknd 6565 16 boy boy NN cord-010119-t1x9gknd 6565 17 by by IN cord-010119-t1x9gknd 6565 18 vaginal vaginal JJ cord-010119-t1x9gknd 6565 19 route route NN cord-010119-t1x9gknd 6565 20 . . . cord-010119-t1x9gknd 6566 1 The the DT cord-010119-t1x9gknd 6566 2 delivery delivery NN cord-010119-t1x9gknd 6566 3 was be VBD cord-010119-t1x9gknd 6566 4 without without IN cord-010119-t1x9gknd 6566 5 event event NN cord-010119-t1x9gknd 6566 6 . . . cord-010119-t1x9gknd 6567 1 No no DT cord-010119-t1x9gknd 6567 2 transfusions transfusion NNS cord-010119-t1x9gknd 6567 3 were be VBD cord-010119-t1x9gknd 6567 4 necessary necessary JJ cord-010119-t1x9gknd 6567 5 antepartum antepartum JJ cord-010119-t1x9gknd 6567 6 or or CC cord-010119-t1x9gknd 6567 7 postpartum postpartum NN cord-010119-t1x9gknd 6567 8 . . . cord-010119-t1x9gknd 6568 1 Study Study NNP cord-010119-t1x9gknd 6568 2 Design Design NNP cord-010119-t1x9gknd 6568 3 / / SYM cord-010119-t1x9gknd 6568 4 Methods method NNS cord-010119-t1x9gknd 6568 5 : : : cord-010119-t1x9gknd 6569 1 N/ N/ NNP cord-010119-t1x9gknd 6570 1 A a DT cord-010119-t1x9gknd 6571 1 Results result NNS cord-010119-t1x9gknd 6571 2 / / SYM cord-010119-t1x9gknd 6571 3 Findings finding NNS cord-010119-t1x9gknd 6571 4 : : : cord-010119-t1x9gknd 6572 1 N N NNP cord-010119-t1x9gknd 6572 2 / / SYM cord-010119-t1x9gknd 6572 3 A a DT cord-010119-t1x9gknd 6572 4 Conclusion conclusion NN cord-010119-t1x9gknd 6572 5 : : : cord-010119-t1x9gknd 6572 6 Anti anti JJ cord-010119-t1x9gknd 6572 7 - - JJ cord-010119-t1x9gknd 6572 8 En(a En(a NNP cord-010119-t1x9gknd 6572 9 ) ) -RRB- cord-010119-t1x9gknd 6572 10 is be VBZ cord-010119-t1x9gknd 6572 11 a a DT cord-010119-t1x9gknd 6572 12 rare rare JJ cord-010119-t1x9gknd 6572 13 antibody antibody NN cord-010119-t1x9gknd 6572 14 and and CC cord-010119-t1x9gknd 6572 15 there there EX cord-010119-t1x9gknd 6572 16 is be VBZ cord-010119-t1x9gknd 6572 17 limited limited JJ cord-010119-t1x9gknd 6572 18 data datum NNS cord-010119-t1x9gknd 6572 19 about about IN cord-010119-t1x9gknd 6572 20 its -PRON- PRP$ cord-010119-t1x9gknd 6572 21 potential potential JJ cord-010119-t1x9gknd 6572 22 clinical clinical JJ cord-010119-t1x9gknd 6572 23 sequelae sequela NNS cord-010119-t1x9gknd 6572 24 , , , cord-010119-t1x9gknd 6572 25 which which WDT cord-010119-t1x9gknd 6572 26 is be VBZ cord-010119-t1x9gknd 6572 27 concerning concern VBG cord-010119-t1x9gknd 6572 28 in in IN cord-010119-t1x9gknd 6572 29 a a DT cord-010119-t1x9gknd 6572 30 pregnant pregnant JJ cord-010119-t1x9gknd 6572 31 woman woman NN cord-010119-t1x9gknd 6572 32 . . . cord-010119-t1x9gknd 6573 1 Providing provide VBG cord-010119-t1x9gknd 6573 2 this this DT cord-010119-t1x9gknd 6573 3 patient patient NN cord-010119-t1x9gknd 6573 4 with with IN cord-010119-t1x9gknd 6573 5 rare rare JJ cord-010119-t1x9gknd 6573 6 En(a En(a NNP cord-010119-t1x9gknd 6573 7 ) ) -RRB- cord-010119-t1x9gknd 6573 8 negative negative JJ cord-010119-t1x9gknd 6573 9 red red JJ cord-010119-t1x9gknd 6573 10 cells cell NNS cord-010119-t1x9gknd 6573 11 via via IN cord-010119-t1x9gknd 6573 12 national national JJ cord-010119-t1x9gknd 6573 13 or or CC cord-010119-t1x9gknd 6573 14 international international JJ cord-010119-t1x9gknd 6573 15 blood blood NN cord-010119-t1x9gknd 6573 16 donor donor NN cord-010119-t1x9gknd 6573 17 registries registry NNS cord-010119-t1x9gknd 6573 18 would would MD cord-010119-t1x9gknd 6573 19 have have VB cord-010119-t1x9gknd 6573 20 been be VBN cord-010119-t1x9gknd 6573 21 an an DT cord-010119-t1x9gknd 6573 22 arduous arduous JJ cord-010119-t1x9gknd 6573 23 task task NN cord-010119-t1x9gknd 6573 24 if if IN cord-010119-t1x9gknd 6573 25 needed need VBN cord-010119-t1x9gknd 6573 26 . . . cord-010119-t1x9gknd 6574 1 This this DT cord-010119-t1x9gknd 6574 2 patient patient NN cord-010119-t1x9gknd 6574 3 had have VBD cord-010119-t1x9gknd 6574 4 many many JJ cord-010119-t1x9gknd 6574 5 compatible compatible JJ cord-010119-t1x9gknd 6574 6 family family NN cord-010119-t1x9gknd 6574 7 members member NNS cord-010119-t1x9gknd 6574 8 available available JJ cord-010119-t1x9gknd 6574 9 and and CC cord-010119-t1x9gknd 6574 10 willing willing JJ cord-010119-t1x9gknd 6574 11 to to TO cord-010119-t1x9gknd 6574 12 donate donate VB cord-010119-t1x9gknd 6574 13 blood blood NN cord-010119-t1x9gknd 6574 14 . . . cord-010119-t1x9gknd 6575 1 The the DT cord-010119-t1x9gknd 6575 2 M(k m(k NN cord-010119-t1x9gknd 6575 3 ) ) -RRB- cord-010119-t1x9gknd 6576 1 null null JJ cord-010119-t1x9gknd 6576 2 allele allele NN cord-010119-t1x9gknd 6576 3 ( ( -LRB- cord-010119-t1x9gknd 6576 4 s s NN cord-010119-t1x9gknd 6576 5 ) ) -RRB- cord-010119-t1x9gknd 6576 6 within within IN cord-010119-t1x9gknd 6576 7 this this DT cord-010119-t1x9gknd 6576 8 family family NN cord-010119-t1x9gknd 6576 9 is be VBZ cord-010119-t1x9gknd 6576 10 likely likely JJ cord-010119-t1x9gknd 6576 11 due due IN cord-010119-t1x9gknd 6576 12 to to IN cord-010119-t1x9gknd 6576 13 a a DT cord-010119-t1x9gknd 6576 14 genetic genetic JJ cord-010119-t1x9gknd 6576 15 recombination recombination NN cord-010119-t1x9gknd 6576 16 among among IN cord-010119-t1x9gknd 6576 17 the the DT cord-010119-t1x9gknd 6576 18 GYPA GYPA NNP cord-010119-t1x9gknd 6576 19 and and CC cord-010119-t1x9gknd 6576 20 GYPE GYPE NNP cord-010119-t1x9gknd 6576 21 genes gene NNS cord-010119-t1x9gknd 6576 22 rather rather RB cord-010119-t1x9gknd 6576 23 than than IN cord-010119-t1x9gknd 6576 24 a a DT cord-010119-t1x9gknd 6576 25 mutation mutation NN cord-010119-t1x9gknd 6576 26 in in IN cord-010119-t1x9gknd 6576 27 both both CC cord-010119-t1x9gknd 6576 28 the the DT cord-010119-t1x9gknd 6576 29 GYPA GYPA NNP cord-010119-t1x9gknd 6576 30 and and CC cord-010119-t1x9gknd 6576 31 GYPB GYPB NNP cord-010119-t1x9gknd 6576 32 genes gene NNS cord-010119-t1x9gknd 6576 33 [ [ -LRB- cord-010119-t1x9gknd 6576 34 3 3 CD cord-010119-t1x9gknd 6576 35 ] ] -RRB- cord-010119-t1x9gknd 6576 36 . . . cord-010119-t1x9gknd 6577 1 This this DT cord-010119-t1x9gknd 6577 2 results result VBZ cord-010119-t1x9gknd 6577 3 in in IN cord-010119-t1x9gknd 6577 4 the the DT cord-010119-t1x9gknd 6577 5 absence absence NN cord-010119-t1x9gknd 6577 6 of of IN cord-010119-t1x9gknd 6577 7 glycophorins glycophorin NNS cord-010119-t1x9gknd 6577 8 A A NNP cord-010119-t1x9gknd 6577 9 and and CC cord-010119-t1x9gknd 6577 10 B b NN cord-010119-t1x9gknd 6577 11 and and CC cord-010119-t1x9gknd 6577 12 the the DT cord-010119-t1x9gknd 6577 13 constitutive constitutive JJ cord-010119-t1x9gknd 6577 14 antigens antigen NNS cord-010119-t1x9gknd 6577 15 of of IN cord-010119-t1x9gknd 6577 16 the the DT cord-010119-t1x9gknd 6577 17 MNS MNS NNP cord-010119-t1x9gknd 6577 18 blood blood NN cord-010119-t1x9gknd 6577 19 group group NN cord-010119-t1x9gknd 6577 20 system system NN cord-010119-t1x9gknd 6577 21 . . . cord-010119-t1x9gknd 6578 1 Our -PRON- PRP$ cord-010119-t1x9gknd 6578 2 patient patient NN cord-010119-t1x9gknd 6578 3 was be VBD cord-010119-t1x9gknd 6578 4 exposed expose VBN cord-010119-t1x9gknd 6578 5 to to IN cord-010119-t1x9gknd 6578 6 the the DT cord-010119-t1x9gknd 6578 7 En(a En(a NNP cord-010119-t1x9gknd 6578 8 ) ) -RRB- cord-010119-t1x9gknd 6578 9 present present JJ cord-010119-t1x9gknd 6578 10 on on IN cord-010119-t1x9gknd 6578 11 glycophorin glycophorin NNP cord-010119-t1x9gknd 6578 12 A A NNP cord-010119-t1x9gknd 6578 13 on on IN cord-010119-t1x9gknd 6578 14 her -PRON- PRP$ cord-010119-t1x9gknd 6578 15 unborn unborn JJ cord-010119-t1x9gknd 6578 16 baby baby NN cord-010119-t1x9gknd 6578 17 's 's POS cord-010119-t1x9gknd 6578 18 red red JJ cord-010119-t1x9gknd 6578 19 cells cell NNS cord-010119-t1x9gknd 6578 20 ( ( -LRB- cord-010119-t1x9gknd 6578 21 inherited inherit VBN cord-010119-t1x9gknd 6578 22 from from IN cord-010119-t1x9gknd 6578 23 father father NN cord-010119-t1x9gknd 6578 24 ) ) -RRB- cord-010119-t1x9gknd 6578 25 in in IN cord-010119-t1x9gknd 6578 26 utero utero NN cord-010119-t1x9gknd 6578 27 with with IN cord-010119-t1x9gknd 6578 28 subsequent subsequent JJ cord-010119-t1x9gknd 6578 29 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6578 30 . . . cord-010119-t1x9gknd 6579 1 In in IN cord-010119-t1x9gknd 6579 2 conclusion conclusion NN cord-010119-t1x9gknd 6579 3 , , , cord-010119-t1x9gknd 6579 4 this this DT cord-010119-t1x9gknd 6579 5 case case NN cord-010119-t1x9gknd 6579 6 report report NN cord-010119-t1x9gknd 6579 7 demonstrates demonstrate VBZ cord-010119-t1x9gknd 6579 8 a a DT cord-010119-t1x9gknd 6579 9 clinical clinical JJ cord-010119-t1x9gknd 6579 10 approach approach NN cord-010119-t1x9gknd 6579 11 in in IN cord-010119-t1x9gknd 6579 12 identifying identify VBG cord-010119-t1x9gknd 6579 13 a a DT cord-010119-t1x9gknd 6579 14 rare rare JJ cord-010119-t1x9gknd 6579 15 anti anti JJ cord-010119-t1x9gknd 6579 16 - - JJ cord-010119-t1x9gknd 6579 17 En(a en(a JJ cord-010119-t1x9gknd 6579 18 ) ) -RRB- cord-010119-t1x9gknd 6579 19 antibody antibody NN cord-010119-t1x9gknd 6579 20 in in IN cord-010119-t1x9gknd 6579 21 a a DT cord-010119-t1x9gknd 6579 22 prenatal prenatal JJ cord-010119-t1x9gknd 6579 23 sample sample NN cord-010119-t1x9gknd 6579 24 . . . cord-010119-t1x9gknd 6580 1 The the DT cord-010119-t1x9gknd 6580 2 clinical clinical JJ cord-010119-t1x9gknd 6580 3 finding finding NN cord-010119-t1x9gknd 6580 4 of of IN cord-010119-t1x9gknd 6580 5 a a DT cord-010119-t1x9gknd 6580 6 rare rare JJ cord-010119-t1x9gknd 6580 7 antibody antibody NN cord-010119-t1x9gknd 6580 8 in in IN cord-010119-t1x9gknd 6580 9 which which WDT cord-010119-t1x9gknd 6580 10 there there EX cord-010119-t1x9gknd 6580 11 is be VBZ cord-010119-t1x9gknd 6580 12 limited limited JJ cord-010119-t1x9gknd 6580 13 data datum NNS cord-010119-t1x9gknd 6580 14 requires require VBZ cord-010119-t1x9gknd 6580 15 leveraging leverage VBG cord-010119-t1x9gknd 6580 16 every every DT cord-010119-t1x9gknd 6580 17 resource resource NN cord-010119-t1x9gknd 6580 18 available available JJ cord-010119-t1x9gknd 6580 19 in in IN cord-010119-t1x9gknd 6580 20 order order NN cord-010119-t1x9gknd 6580 21 to to TO cord-010119-t1x9gknd 6580 22 predict predict VB cord-010119-t1x9gknd 6580 23 its -PRON- PRP$ cord-010119-t1x9gknd 6580 24 behavior behavior NN cord-010119-t1x9gknd 6580 25 and and CC cord-010119-t1x9gknd 6580 26 provide provide VB cord-010119-t1x9gknd 6580 27 safe safe JJ cord-010119-t1x9gknd 6580 28 blood blood NN cord-010119-t1x9gknd 6580 29 products product NNS cord-010119-t1x9gknd 6580 30 to to IN cord-010119-t1x9gknd 6580 31 patients patient NNS cord-010119-t1x9gknd 6580 32 who who WP cord-010119-t1x9gknd 6580 33 may may MD cord-010119-t1x9gknd 6580 34 require require VB cord-010119-t1x9gknd 6580 35 it -PRON- PRP cord-010119-t1x9gknd 6580 36 . . . cord-010119-t1x9gknd 6581 1 Background Background NNP cord-010119-t1x9gknd 6581 2 / / SYM cord-010119-t1x9gknd 6581 3 Case Case NNP cord-010119-t1x9gknd 6581 4 Studies Studies NNPS cord-010119-t1x9gknd 6581 5 : : : cord-010119-t1x9gknd 6582 1 Transfusions transfusion NNS cord-010119-t1x9gknd 6582 2 are be VBP cord-010119-t1x9gknd 6582 3 essential essential JJ cord-010119-t1x9gknd 6582 4 for for IN cord-010119-t1x9gknd 6582 5 patients patient NNS cord-010119-t1x9gknd 6582 6 with with IN cord-010119-t1x9gknd 6582 7 SCD SCD NNP cord-010119-t1x9gknd 6582 8 and and CC cord-010119-t1x9gknd 6582 9 thalassemia thalassemia NN cord-010119-t1x9gknd 6582 10 to to TO cord-010119-t1x9gknd 6582 11 maintain maintain VB cord-010119-t1x9gknd 6582 12 growth growth NN cord-010119-t1x9gknd 6582 13 and and CC cord-010119-t1x9gknd 6582 14 development development NN cord-010119-t1x9gknd 6582 15 during during IN cord-010119-t1x9gknd 6582 16 childhood childhood NN cord-010119-t1x9gknd 6582 17 and and CC cord-010119-t1x9gknd 6582 18 to to TO cord-010119-t1x9gknd 6582 19 sustain sustain VB cord-010119-t1x9gknd 6582 20 good good JJ cord-010119-t1x9gknd 6582 21 quality quality NN cord-010119-t1x9gknd 6582 22 of of IN cord-010119-t1x9gknd 6582 23 life life NN cord-010119-t1x9gknd 6582 24 during during IN cord-010119-t1x9gknd 6582 25 adulthood adulthood NN cord-010119-t1x9gknd 6582 26 ; ; : cord-010119-t1x9gknd 6582 27 however however RB cord-010119-t1x9gknd 6582 28 , , , cord-010119-t1x9gknd 6582 29 the the DT cord-010119-t1x9gknd 6582 30 development development NN cord-010119-t1x9gknd 6582 31 of of IN cord-010119-t1x9gknd 6582 32 red red JJ cord-010119-t1x9gknd 6582 33 blood blood NN cord-010119-t1x9gknd 6582 34 cell cell NN cord-010119-t1x9gknd 6582 35 ( ( -LRB- cord-010119-t1x9gknd 6582 36 RBC RBC NNP cord-010119-t1x9gknd 6582 37 ) ) -RRB- cord-010119-t1x9gknd 6582 38 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6582 39 and and CC cord-010119-t1x9gknd 6582 40 autoantibodies autoantibody NNS cord-010119-t1x9gknd 6582 41 complicates complicate VBZ cord-010119-t1x9gknd 6582 42 transfusion transfusion NN cord-010119-t1x9gknd 6582 43 therapy therapy NN cord-010119-t1x9gknd 6582 44 in in IN cord-010119-t1x9gknd 6582 45 such such JJ cord-010119-t1x9gknd 6582 46 patients patient NNS cord-010119-t1x9gknd 6582 47 . . . cord-010119-t1x9gknd 6583 1 Routine routine JJ cord-010119-t1x9gknd 6583 2 phenotyping phenotyping NN cord-010119-t1x9gknd 6583 3 of of IN cord-010119-t1x9gknd 6583 4 blood blood NN cord-010119-t1x9gknd 6583 5 recipients recipient NNS cord-010119-t1x9gknd 6583 6 and and CC cord-010119-t1x9gknd 6583 7 the the DT cord-010119-t1x9gknd 6583 8 use use NN cord-010119-t1x9gknd 6583 9 of of IN cord-010119-t1x9gknd 6583 10 phenotype phenotype NN cord-010119-t1x9gknd 6583 11 - - HYPH cord-010119-t1x9gknd 6583 12 matched match VBN cord-010119-t1x9gknd 6583 13 blood blood NN cord-010119-t1x9gknd 6583 14 units unit NNS cord-010119-t1x9gknd 6583 15 for for IN cord-010119-t1x9gknd 6583 16 transfusion transfusion NN cord-010119-t1x9gknd 6583 17 has have VBZ cord-010119-t1x9gknd 6583 18 been be VBN cord-010119-t1x9gknd 6583 19 useful useful JJ cord-010119-t1x9gknd 6583 20 to to TO cord-010119-t1x9gknd 6583 21 lower lower VB cord-010119-t1x9gknd 6583 22 the the DT cord-010119-t1x9gknd 6583 23 occurrence occurrence NN cord-010119-t1x9gknd 6583 24 of of IN cord-010119-t1x9gknd 6583 25 red red JJ cord-010119-t1x9gknd 6583 26 cell cell NN cord-010119-t1x9gknd 6583 27 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6583 28 in in IN cord-010119-t1x9gknd 6583 29 chronically chronically RB cord-010119-t1x9gknd 6583 30 transfused transfuse VBN cord-010119-t1x9gknd 6583 31 patients patient NNS cord-010119-t1x9gknd 6583 32 with with IN cord-010119-t1x9gknd 6583 33 thalassemia thalassemia NN cord-010119-t1x9gknd 6583 34 and and CC cord-010119-t1x9gknd 6583 35 SCD SCD NNP cord-010119-t1x9gknd 6583 36 . . . cord-010119-t1x9gknd 6584 1 Nevertheless nevertheless RB cord-010119-t1x9gknd 6584 2 , , , cord-010119-t1x9gknd 6584 3 extensive extensive JJ cord-010119-t1x9gknd 6584 4 phenotyping phenotyping NN cord-010119-t1x9gknd 6584 5 is be VBZ cord-010119-t1x9gknd 6584 6 expensive expensive JJ cord-010119-t1x9gknd 6584 7 , , , cord-010119-t1x9gknd 6584 8 laborious laborious JJ cord-010119-t1x9gknd 6584 9 and and CC cord-010119-t1x9gknd 6584 10 can can MD cord-010119-t1x9gknd 6584 11 not not RB cord-010119-t1x9gknd 6584 12 be be VB cord-010119-t1x9gknd 6584 13 performed perform VBN cord-010119-t1x9gknd 6584 14 in in IN cord-010119-t1x9gknd 6584 15 certain certain JJ cord-010119-t1x9gknd 6584 16 situations situation NNS cord-010119-t1x9gknd 6584 17 . . . cord-010119-t1x9gknd 6585 1 The the DT cord-010119-t1x9gknd 6585 2 molecular molecular JJ cord-010119-t1x9gknd 6585 3 understanding understanding NN cord-010119-t1x9gknd 6585 4 of of IN cord-010119-t1x9gknd 6585 5 blood blood NN cord-010119-t1x9gknd 6585 6 groups group NNS cord-010119-t1x9gknd 6585 7 has have VBZ cord-010119-t1x9gknd 6585 8 enabled enable VBN cord-010119-t1x9gknd 6585 9 the the DT cord-010119-t1x9gknd 6585 10 design design NN cord-010119-t1x9gknd 6585 11 of of IN cord-010119-t1x9gknd 6585 12 assays assay NNS cord-010119-t1x9gknd 6585 13 137A 137a CD cord-010119-t1x9gknd 6585 14 TRANSFUSION transfusion NN cord-010119-t1x9gknd 6585 15 2017 2017 CD cord-010119-t1x9gknd 6585 16 Vol Vol NNP cord-010119-t1x9gknd 6585 17 . . . cord-010119-t1x9gknd 6586 1 57 57 CD cord-010119-t1x9gknd 6586 2 Supplement supplement NN cord-010119-t1x9gknd 6586 3 S3 S3 NNP cord-010119-t1x9gknd 6586 4 that that WDT cord-010119-t1x9gknd 6586 5 are be VBP cord-010119-t1x9gknd 6586 6 being be VBG cord-010119-t1x9gknd 6586 7 used use VBN cord-010119-t1x9gknd 6586 8 to to TO cord-010119-t1x9gknd 6586 9 better well RBR cord-010119-t1x9gknd 6586 10 guide guide VB cord-010119-t1x9gknd 6586 11 matched match VBN cord-010119-t1x9gknd 6586 12 red red JJ cord-010119-t1x9gknd 6586 13 blood blood NN cord-010119-t1x9gknd 6586 14 cell cell NN cord-010119-t1x9gknd 6586 15 transfusions transfusion NNS cord-010119-t1x9gknd 6586 16 and and CC cord-010119-t1x9gknd 6586 17 to to TO cord-010119-t1x9gknd 6586 18 maintain maintain VB cord-010119-t1x9gknd 6586 19 an an DT cord-010119-t1x9gknd 6586 20 inventory inventory NN cord-010119-t1x9gknd 6586 21 of of IN cord-010119-t1x9gknd 6586 22 units unit NNS cord-010119-t1x9gknd 6586 23 DNA DNA NNP cord-010119-t1x9gknd 6586 24 typed type VBN cord-010119-t1x9gknd 6586 25 . . . cord-010119-t1x9gknd 6587 1 Based base VBN cord-010119-t1x9gknd 6587 2 on on IN cord-010119-t1x9gknd 6587 3 this this DT cord-010119-t1x9gknd 6587 4 , , , cord-010119-t1x9gknd 6587 5 our -PRON- PRP$ cord-010119-t1x9gknd 6587 6 aim aim NN cord-010119-t1x9gknd 6587 7 was be VBD cord-010119-t1x9gknd 6587 8 to to TO cord-010119-t1x9gknd 6587 9 evaluate evaluate VB cord-010119-t1x9gknd 6587 10 the the DT cord-010119-t1x9gknd 6587 11 clinical clinical JJ cord-010119-t1x9gknd 6587 12 outcomes outcome NNS cord-010119-t1x9gknd 6587 13 of of IN cord-010119-t1x9gknd 6587 14 molecular molecular JJ cord-010119-t1x9gknd 6587 15 matching matching NN cord-010119-t1x9gknd 6587 16 performed perform VBN cord-010119-t1x9gknd 6587 17 at at IN cord-010119-t1x9gknd 6587 18 different different JJ cord-010119-t1x9gknd 6587 19 levels level NNS cord-010119-t1x9gknd 6587 20 during during IN cord-010119-t1x9gknd 6587 21 3 3 CD cord-010119-t1x9gknd 6587 22 years year NNS cord-010119-t1x9gknd 6587 23 for for IN cord-010119-t1x9gknd 6587 24 patients patient NNS cord-010119-t1x9gknd 6587 25 with with IN cord-010119-t1x9gknd 6587 26 SCD SCD NNP cord-010119-t1x9gknd 6587 27 and and CC cord-010119-t1x9gknd 6587 28 thalassemia thalassemia NN cord-010119-t1x9gknd 6587 29 . . . cord-010119-t1x9gknd 6588 1 Study Study NNP cord-010119-t1x9gknd 6588 2 Design Design NNP cord-010119-t1x9gknd 6588 3 / / SYM cord-010119-t1x9gknd 6588 4 Method method NN cord-010119-t1x9gknd 6588 5 : : : cord-010119-t1x9gknd 6589 1 Blood blood NN cord-010119-t1x9gknd 6589 2 group group NN cord-010119-t1x9gknd 6589 3 genotypes genotype NNS cord-010119-t1x9gknd 6589 4 were be VBD cord-010119-t1x9gknd 6589 5 determined determine VBN cord-010119-t1x9gknd 6589 6 in in IN cord-010119-t1x9gknd 6589 7 67 67 CD cord-010119-t1x9gknd 6589 8 DNA dna NN cord-010119-t1x9gknd 6589 9 samples sample NNS cord-010119-t1x9gknd 6589 10 from from IN cord-010119-t1x9gknd 6589 11 chronically chronically RB cord-010119-t1x9gknd 6589 12 transfused transfuse VBN cord-010119-t1x9gknd 6589 13 patients patient NNS cord-010119-t1x9gknd 6589 14 with with IN cord-010119-t1x9gknd 6589 15 SCD SCD NNP cord-010119-t1x9gknd 6589 16 , , , cord-010119-t1x9gknd 6589 17 in in IN cord-010119-t1x9gknd 6589 18 65 65 CD cord-010119-t1x9gknd 6589 19 patients patient NNS cord-010119-t1x9gknd 6589 20 with with IN cord-010119-t1x9gknd 6589 21 thalassemia thalassemia NN cord-010119-t1x9gknd 6589 22 and and CC cord-010119-t1x9gknd 6589 23 in in IN cord-010119-t1x9gknd 6589 24 3000 3000 CD cord-010119-t1x9gknd 6589 25 DNA dna NN cord-010119-t1x9gknd 6589 26 samples sample NNS cord-010119-t1x9gknd 6589 27 from from IN cord-010119-t1x9gknd 6589 28 blood blood NN cord-010119-t1x9gknd 6589 29 donors donor NNS cord-010119-t1x9gknd 6589 30 . . . cord-010119-t1x9gknd 6590 1 Laboratory laboratory NN cord-010119-t1x9gknd 6590 2 developed develop VBD cord-010119-t1x9gknd 6590 3 tests test NNS cord-010119-t1x9gknd 6590 4 ( ( -LRB- cord-010119-t1x9gknd 6590 5 LDTs LDTs NNP cord-010119-t1x9gknd 6590 6 ) ) -RRB- cord-010119-t1x9gknd 6590 7 , , , cord-010119-t1x9gknd 6590 8 HEA HEA NNP cord-010119-t1x9gknd 6590 9 BeadChip BeadChip NNP cord-010119-t1x9gknd 6590 10 TM TM NNP cord-010119-t1x9gknd 6590 11 , , , cord-010119-t1x9gknd 6590 12 RHD RHD NNP cord-010119-t1x9gknd 6590 13 BeadChip BeadChip NNP cord-010119-t1x9gknd 6590 14 TM TM NNP cord-010119-t1x9gknd 6590 15 , , , cord-010119-t1x9gknd 6590 16 RHCE RHCE NNP cord-010119-t1x9gknd 6590 17 Bead Bead NNP cord-010119-t1x9gknd 6590 18 - - HYPH cord-010119-t1x9gknd 6590 19 Chip Chip NNP cord-010119-t1x9gknd 6590 20 TM TM NNP cord-010119-t1x9gknd 6590 21 , , , cord-010119-t1x9gknd 6590 22 and and CC cord-010119-t1x9gknd 6590 23 sequencing sequencing NN cord-010119-t1x9gknd 6590 24 were be VBD cord-010119-t1x9gknd 6590 25 used use VBN cord-010119-t1x9gknd 6590 26 to to TO cord-010119-t1x9gknd 6590 27 determine determine VB cord-010119-t1x9gknd 6590 28 the the DT cord-010119-t1x9gknd 6590 29 genotypes genotype NNS cord-010119-t1x9gknd 6590 30 among among IN cord-010119-t1x9gknd 6590 31 patients patient NNS cord-010119-t1x9gknd 6590 32 and and CC cord-010119-t1x9gknd 6590 33 donors donor NNS cord-010119-t1x9gknd 6590 34 . . . cord-010119-t1x9gknd 6591 1 Molecular molecular JJ cord-010119-t1x9gknd 6591 2 matching matching NN cord-010119-t1x9gknd 6591 3 was be VBD cord-010119-t1x9gknd 6591 4 performed perform VBN cord-010119-t1x9gknd 6591 5 in in IN cord-010119-t1x9gknd 6591 6 3 3 CD cord-010119-t1x9gknd 6591 7 levels level NNS cord-010119-t1x9gknd 6591 8 : : : cord-010119-t1x9gknd 6591 9 ( ( -LRB- cord-010119-t1x9gknd 6591 10 1 1 LS cord-010119-t1x9gknd 6591 11 ) ) -RRB- cord-010119-t1x9gknd 6591 12 RH RH NNP cord-010119-t1x9gknd 6591 13 and and CC cord-010119-t1x9gknd 6591 14 K K NNP cord-010119-t1x9gknd 6591 15 matching matching NN cord-010119-t1x9gknd 6591 16 ; ; : cord-010119-t1x9gknd 6591 17 ( ( -LRB- cord-010119-t1x9gknd 6591 18 2 2 LS cord-010119-t1x9gknd 6591 19 ) ) -RRB- cord-010119-t1x9gknd 6591 20 extended extend VBN cord-010119-t1x9gknd 6591 21 matching matching NN cord-010119-t1x9gknd 6591 22 and and CC cord-010119-t1x9gknd 6591 23 ( ( -LRB- cord-010119-t1x9gknd 6591 24 3 3 LS cord-010119-t1x9gknd 6591 25 ) ) -RRB- cord-010119-t1x9gknd 6591 26 extended extend VBN cord-010119-t1x9gknd 6591 27 matching matching NN cord-010119-t1x9gknd 6591 28 including include VBG cord-010119-t1x9gknd 6591 29 RH RH NNP cord-010119-t1x9gknd 6591 30 variants variant NNS cord-010119-t1x9gknd 6591 31 . . . cord-010119-t1x9gknd 6592 1 We -PRON- PRP cord-010119-t1x9gknd 6592 2 considered consider VBD cord-010119-t1x9gknd 6592 3 the the DT cord-010119-t1x9gknd 6592 4 total total NN cord-010119-t1x9gknd 6592 5 of of IN cord-010119-t1x9gknd 6592 6 red red JJ cord-010119-t1x9gknd 6592 7 blood blood NN cord-010119-t1x9gknd 6592 8 cell cell NN cord-010119-t1x9gknd 6592 9 units unit NNS cord-010119-t1x9gknd 6592 10 requested request VBN cord-010119-t1x9gknd 6592 11 for for IN cord-010119-t1x9gknd 6592 12 each each DT cord-010119-t1x9gknd 6592 13 patient patient NN cord-010119-t1x9gknd 6592 14 and and CC cord-010119-t1x9gknd 6592 15 a a DT cord-010119-t1x9gknd 6592 16 number number NN cord-010119-t1x9gknd 6592 17 of of IN cord-010119-t1x9gknd 6592 18 2 2 CD cord-010119-t1x9gknd 6592 19 donations donation NNS cord-010119-t1x9gknd 6592 20 per per IN cord-010119-t1x9gknd 6592 21 year year NN cord-010119-t1x9gknd 6592 22 for for IN cord-010119-t1x9gknd 6592 23 the the DT cord-010119-t1x9gknd 6592 24 compatible compatible JJ cord-010119-t1x9gknd 6592 25 donors donor NNS cord-010119-t1x9gknd 6592 26 . . . cord-010119-t1x9gknd 6593 1 Results result NNS cord-010119-t1x9gknd 6593 2 / / SYM cord-010119-t1x9gknd 6593 3 Finding finding NN cord-010119-t1x9gknd 6593 4 : : : cord-010119-t1x9gknd 6594 1 According accord VBG cord-010119-t1x9gknd 6594 2 to to IN cord-010119-t1x9gknd 6594 3 the the DT cord-010119-t1x9gknd 6594 4 patients patient NNS cord-010119-t1x9gknd 6594 5 needs need VBZ cord-010119-t1x9gknd 6594 6 we -PRON- PRP cord-010119-t1x9gknd 6594 7 performed perform VBD cord-010119-t1x9gknd 6594 8 molecular molecular JJ cord-010119-t1x9gknd 6594 9 matching matching NN cord-010119-t1x9gknd 6594 10 for for IN cord-010119-t1x9gknd 6594 11 100 100 CD cord-010119-t1x9gknd 6594 12 % % NN cord-010119-t1x9gknd 6594 13 of of IN cord-010119-t1x9gknd 6594 14 our -PRON- PRP$ cord-010119-t1x9gknd 6594 15 thalassemic thalassemic NNP cord-010119-t1x9gknd 6594 16 and and CC cord-010119-t1x9gknd 6594 17 SCD SCD NNP cord-010119-t1x9gknd 6594 18 patients patient NNS cord-010119-t1x9gknd 6594 19 at at IN cord-010119-t1x9gknd 6594 20 level level NN cord-010119-t1x9gknd 6594 21 1 1 CD cord-010119-t1x9gknd 6594 22 , , , cord-010119-t1x9gknd 6594 23 90 90 CD cord-010119-t1x9gknd 6594 24 % % NN cord-010119-t1x9gknd 6594 25 for for IN cord-010119-t1x9gknd 6594 26 SCD SCD NNP cord-010119-t1x9gknd 6594 27 patients patient NNS cord-010119-t1x9gknd 6594 28 and and CC cord-010119-t1x9gknd 6594 29 70 70 CD cord-010119-t1x9gknd 6594 30 % % NN cord-010119-t1x9gknd 6594 31 for for IN cord-010119-t1x9gknd 6594 32 patients patient NNS cord-010119-t1x9gknd 6594 33 with with IN cord-010119-t1x9gknd 6594 34 thalassemia thalassemia NN cord-010119-t1x9gknd 6594 35 at at IN cord-010119-t1x9gknd 6594 36 level level NN cord-010119-t1x9gknd 6594 37 2 2 CD cord-010119-t1x9gknd 6594 38 and and CC cord-010119-t1x9gknd 6594 39 30 30 CD cord-010119-t1x9gknd 6594 40 % % NN cord-010119-t1x9gknd 6594 41 for for IN cord-010119-t1x9gknd 6594 42 patients patient NNS cord-010119-t1x9gknd 6594 43 with with IN cord-010119-t1x9gknd 6594 44 SCD SCD NNP cord-010119-t1x9gknd 6594 45 and and CC cord-010119-t1x9gknd 6594 46 90 90 CD cord-010119-t1x9gknd 6594 47 % % NN cord-010119-t1x9gknd 6594 48 for for IN cord-010119-t1x9gknd 6594 49 patients patient NNS cord-010119-t1x9gknd 6594 50 with with IN cord-010119-t1x9gknd 6594 51 thalassemia thalassemia NN cord-010119-t1x9gknd 6594 52 at at IN cord-010119-t1x9gknd 6594 53 level level NN cord-010119-t1x9gknd 6594 54 3 3 CD cord-010119-t1x9gknd 6594 55 . . . cord-010119-t1x9gknd 6595 1 The the DT cord-010119-t1x9gknd 6595 2 patients patient NNS cord-010119-t1x9gknd 6595 3 were be VBD cord-010119-t1x9gknd 6595 4 transfused transfuse VBN cord-010119-t1x9gknd 6595 5 with with IN cord-010119-t1x9gknd 6595 6 a a DT cord-010119-t1x9gknd 6595 7 median median NN cord-010119-t1x9gknd 6595 8 of of IN cord-010119-t1x9gknd 6595 9 36.4 36.4 CD cord-010119-t1x9gknd 6595 10 RBC RBC NNP cord-010119-t1x9gknd 6595 11 units unit NNS cord-010119-t1x9gknd 6595 12 . . . cord-010119-t1x9gknd 6596 1 After after IN cord-010119-t1x9gknd 6596 2 three three CD cord-010119-t1x9gknd 6596 3 years year NNS cord-010119-t1x9gknd 6596 4 of of IN cord-010119-t1x9gknd 6596 5 molecular molecular JJ cord-010119-t1x9gknd 6596 6 matching matching NN cord-010119-t1x9gknd 6596 7 , , , cord-010119-t1x9gknd 6596 8 we -PRON- PRP cord-010119-t1x9gknd 6596 9 observed observe VBD cord-010119-t1x9gknd 6596 10 that that IN cord-010119-t1x9gknd 6596 11 this this DT cord-010119-t1x9gknd 6596 12 transfusion transfusion NN cord-010119-t1x9gknd 6596 13 strategy strategy NN cord-010119-t1x9gknd 6596 14 avoided avoid VBD cord-010119-t1x9gknd 6596 15 new new JJ cord-010119-t1x9gknd 6596 16 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6596 17 development development NN cord-010119-t1x9gknd 6596 18 and and CC cord-010119-t1x9gknd 6596 19 hemolytic hemolytic JJ cord-010119-t1x9gknd 6596 20 transfusion transfusion NN cord-010119-t1x9gknd 6596 21 reactions reaction NNS cord-010119-t1x9gknd 6596 22 in in IN cord-010119-t1x9gknd 6596 23 all all DT cord-010119-t1x9gknd 6596 24 studied study VBN cord-010119-t1x9gknd 6596 25 patients patient NNS cord-010119-t1x9gknd 6596 26 . . . cord-010119-t1x9gknd 6597 1 Conclusion conclusion NN cord-010119-t1x9gknd 6597 2 : : : cord-010119-t1x9gknd 6598 1 Molecular molecular JJ cord-010119-t1x9gknd 6598 2 matching matching NN cord-010119-t1x9gknd 6598 3 has have VBZ cord-010119-t1x9gknd 6598 4 shown show VBN cord-010119-t1x9gknd 6598 5 clinical clinical JJ cord-010119-t1x9gknd 6598 6 benefits benefit NNS cord-010119-t1x9gknd 6598 7 to to IN cord-010119-t1x9gknd 6598 8 the the DT cord-010119-t1x9gknd 6598 9 patients patient NNS cord-010119-t1x9gknd 6598 10 with with IN cord-010119-t1x9gknd 6598 11 SCD SCD NNP cord-010119-t1x9gknd 6598 12 and and CC cord-010119-t1x9gknd 6598 13 thalassemia thalassemia NN cord-010119-t1x9gknd 6598 14 , , , cord-010119-t1x9gknd 6598 15 contributing contribute VBG cord-010119-t1x9gknd 6598 16 significantly significantly RB cord-010119-t1x9gknd 6598 17 to to TO cord-010119-t1x9gknd 6598 18 reduce reduce VB cord-010119-t1x9gknd 6598 19 the the DT cord-010119-t1x9gknd 6598 20 rates rate NNS cord-010119-t1x9gknd 6598 21 of of IN cord-010119-t1x9gknd 6598 22 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6598 23 to to IN cord-010119-t1x9gknd 6598 24 5 5 CD cord-010119-t1x9gknd 6598 25 - - SYM cord-010119-t1x9gknd 6598 26 10 10 CD cord-010119-t1x9gknd 6598 27 % % NN cord-010119-t1x9gknd 6598 28 with with IN cord-010119-t1x9gknd 6598 29 C c NN cord-010119-t1x9gknd 6598 30 E e NN cord-010119-t1x9gknd 6598 31 K k NN cord-010119-t1x9gknd 6598 32 matching matching NN cord-010119-t1x9gknd 6598 33 and and CC cord-010119-t1x9gknd 6598 34 < < XX cord-010119-t1x9gknd 6598 35 1 1 CD cord-010119-t1x9gknd 6598 36 % % NN cord-010119-t1x9gknd 6598 37 with with IN cord-010119-t1x9gknd 6598 38 extended extended JJ cord-010119-t1x9gknd 6598 39 matching matching NN cord-010119-t1x9gknd 6598 40 . . . cord-010119-t1x9gknd 6599 1 Improvements improvement NNS cord-010119-t1x9gknd 6599 2 in in IN cord-010119-t1x9gknd 6599 3 the the DT cord-010119-t1x9gknd 6599 4 clinical clinical JJ cord-010119-t1x9gknd 6599 5 outcomes outcome NNS cord-010119-t1x9gknd 6599 6 of of IN cord-010119-t1x9gknd 6599 7 the the DT cord-010119-t1x9gknd 6599 8 patients patient NNS cord-010119-t1x9gknd 6599 9 have have VBP cord-010119-t1x9gknd 6599 10 also also RB cord-010119-t1x9gknd 6599 11 been be VBN cord-010119-t1x9gknd 6599 12 observed observe VBN cord-010119-t1x9gknd 6599 13 as as IN cord-010119-t1x9gknd 6599 14 shown show VBN cord-010119-t1x9gknd 6599 15 by by IN cord-010119-t1x9gknd 6599 16 an an DT cord-010119-t1x9gknd 6599 17 increase increase NN cord-010119-t1x9gknd 6599 18 in in IN cord-010119-t1x9gknd 6599 19 their -PRON- PRP$ cord-010119-t1x9gknd 6599 20 Hb Hb NNP cord-010119-t1x9gknd 6599 21 levels level NNS cord-010119-t1x9gknd 6599 22 and and CC cord-010119-t1x9gknd 6599 23 reduction reduction NN cord-010119-t1x9gknd 6599 24 in in IN cord-010119-t1x9gknd 6599 25 the the DT cord-010119-t1x9gknd 6599 26 % % NN cord-010119-t1x9gknd 6599 27 of of IN cord-010119-t1x9gknd 6599 28 HbS hbs NN cord-010119-t1x9gknd 6599 29 in in IN cord-010119-t1x9gknd 6599 30 SCD SCD NNP cord-010119-t1x9gknd 6599 31 patients patient NNS cord-010119-t1x9gknd 6599 32 , , , cord-010119-t1x9gknd 6599 33 better well JJR cord-010119-t1x9gknd 6599 34 in in IN cord-010119-t1x9gknd 6599 35 vivo vivo NNP cord-010119-t1x9gknd 6599 36 RBC RBC NNP cord-010119-t1x9gknd 6599 37 survival survival NN cord-010119-t1x9gknd 6599 38 and and CC cord-010119-t1x9gknd 6599 39 diminished diminished JJ cord-010119-t1x9gknd 6599 40 frequency frequency NN cord-010119-t1x9gknd 6599 41 of of IN cord-010119-t1x9gknd 6599 42 transfusions transfusion NNS cord-010119-t1x9gknd 6599 43 . . . cord-010119-t1x9gknd 6600 1 Allahna Allahna NNP cord-010119-t1x9gknd 6601 1 Lilly Lilly NNP cord-010119-t1x9gknd 6601 2 Elahie Elahie NNP cord-010119-t1x9gknd 6601 3 * * NFP cord-010119-t1x9gknd 6601 4 and and CC cord-010119-t1x9gknd 6601 5 Sandra Sandra NNP cord-010119-t1x9gknd 6601 6 Fazari Fazari NNP cord-010119-t1x9gknd 6601 7 . . . cord-010119-t1x9gknd 6602 1 Hamilton Hamilton NNP cord-010119-t1x9gknd 6602 2 Regional Regional NNP cord-010119-t1x9gknd 6602 3 Laboratory Laboratory NNP cord-010119-t1x9gknd 6602 4 Medicine Medicine NNP cord-010119-t1x9gknd 6602 5 Program Program NNP cord-010119-t1x9gknd 6602 6 Background Background NNP cord-010119-t1x9gknd 6602 7 / / SYM cord-010119-t1x9gknd 6602 8 Case Case NNP cord-010119-t1x9gknd 6602 9 Studies Studies NNPS cord-010119-t1x9gknd 6602 10 : : : cord-010119-t1x9gknd 6603 1 The the DT cord-010119-t1x9gknd 6603 2 ideal ideal JJ cord-010119-t1x9gknd 6603 3 manual manual JJ cord-010119-t1x9gknd 6603 4 backup backup NN cord-010119-t1x9gknd 6603 5 method method NN cord-010119-t1x9gknd 6603 6 for for IN cord-010119-t1x9gknd 6603 7 an an DT cord-010119-t1x9gknd 6603 8 automated automate VBN cord-010119-t1x9gknd 6603 9 antibody antibody NN cord-010119-t1x9gknd 6603 10 detection detection NN cord-010119-t1x9gknd 6603 11 system system NN cord-010119-t1x9gknd 6603 12 is be VBZ cord-010119-t1x9gknd 6603 13 an an DT cord-010119-t1x9gknd 6603 14 important important JJ cord-010119-t1x9gknd 6603 15 choice choice NN cord-010119-t1x9gknd 6603 16 . . . cord-010119-t1x9gknd 6604 1 Currently currently RB cord-010119-t1x9gknd 6604 2 , , , cord-010119-t1x9gknd 6604 3 our -PRON- PRP$ cord-010119-t1x9gknd 6604 4 backup backup JJ cord-010119-t1x9gknd 6604 5 method method NN cord-010119-t1x9gknd 6604 6 is be VBZ cord-010119-t1x9gknd 6604 7 saline saline NN cord-010119-t1x9gknd 6604 8 tube tube NN cord-010119-t1x9gknd 6604 9 ( ( -LRB- cord-010119-t1x9gknd 6604 10 6 6 CD cord-010119-t1x9gknd 6604 11 drops drop NNS cord-010119-t1x9gknd 6604 12 plasma plasma NN cord-010119-t1x9gknd 6604 13 , , , cord-010119-t1x9gknd 6604 14 30 30 CD cord-010119-t1x9gknd 6604 15 minutes minute NNS cord-010119-t1x9gknd 6604 16 incubation incubation NN cord-010119-t1x9gknd 6604 17 ) ) -RRB- cord-010119-t1x9gknd 6604 18 . . . cord-010119-t1x9gknd 6605 1 The the DT cord-010119-t1x9gknd 6605 2 change change NN cord-010119-t1x9gknd 6605 3 to to IN cord-010119-t1x9gknd 6605 4 either either CC cord-010119-t1x9gknd 6605 5 a a DT cord-010119-t1x9gknd 6605 6 low low JJ cord-010119-t1x9gknd 6605 7 ionic ionic JJ cord-010119-t1x9gknd 6605 8 strength strength NN cord-010119-t1x9gknd 6605 9 solution solution NN cord-010119-t1x9gknd 6605 10 ( ( -LRB- cord-010119-t1x9gknd 6605 11 LISS LISS NNP cord-010119-t1x9gknd 6605 12 ) ) -RRB- cord-010119-t1x9gknd 6605 13 or or CC cord-010119-t1x9gknd 6605 14 polyethylene polyethylene NN cord-010119-t1x9gknd 6605 15 glycol glycol NN cord-010119-t1x9gknd 6605 16 ( ( -LRB- cord-010119-t1x9gknd 6605 17 PEG PEG NNP cord-010119-t1x9gknd 6605 18 ) ) -RRB- cord-010119-t1x9gknd 6605 19 method method NN cord-010119-t1x9gknd 6605 20 would would MD cord-010119-t1x9gknd 6605 21 reduce reduce VB cord-010119-t1x9gknd 6605 22 incubation incubation NN cord-010119-t1x9gknd 6605 23 time time NN cord-010119-t1x9gknd 6605 24 to to IN cord-010119-t1x9gknd 6605 25 10 10 CD cord-010119-t1x9gknd 6605 26 minutes minute NNS cord-010119-t1x9gknd 6605 27 and and CC cord-010119-t1x9gknd 6605 28 specimen specimen NN cord-010119-t1x9gknd 6605 29 volume volume NN cord-010119-t1x9gknd 6605 30 to to IN cord-010119-t1x9gknd 6605 31 2 2 CD cord-010119-t1x9gknd 6605 32 drops drop NNS cord-010119-t1x9gknd 6605 33 , , , cord-010119-t1x9gknd 6605 34 both both DT cord-010119-t1x9gknd 6605 35 important important JJ cord-010119-t1x9gknd 6605 36 laboratory laboratory NN cord-010119-t1x9gknd 6605 37 considerations consideration NNS cord-010119-t1x9gknd 6605 38 . . . cord-010119-t1x9gknd 6606 1 Objectives objective NNS cord-010119-t1x9gknd 6606 2 of of IN cord-010119-t1x9gknd 6606 3 this this DT cord-010119-t1x9gknd 6606 4 study study NN cord-010119-t1x9gknd 6606 5 were be VBD cord-010119-t1x9gknd 6606 6 to to TO cord-010119-t1x9gknd 6606 7 compare compare VB cord-010119-t1x9gknd 6606 8 the the DT cord-010119-t1x9gknd 6606 9 relative relative JJ cord-010119-t1x9gknd 6606 10 sensitivity sensitivity NN cord-010119-t1x9gknd 6606 11 , , , cord-010119-t1x9gknd 6606 12 specificity specificity NN cord-010119-t1x9gknd 6606 13 , , , cord-010119-t1x9gknd 6606 14 positive positive JJ cord-010119-t1x9gknd 6606 15 predictive predictive JJ cord-010119-t1x9gknd 6606 16 value value NN cord-010119-t1x9gknd 6606 17 ( ( -LRB- cord-010119-t1x9gknd 6606 18 PPV PPV NNP cord-010119-t1x9gknd 6606 19 ) ) -RRB- cord-010119-t1x9gknd 6606 20 and and CC cord-010119-t1x9gknd 6606 21 negative negative JJ cord-010119-t1x9gknd 6606 22 predictive predictive JJ cord-010119-t1x9gknd 6606 23 value value NN cord-010119-t1x9gknd 6606 24 ( ( -LRB- cord-010119-t1x9gknd 6606 25 NPV NPV NNP cord-010119-t1x9gknd 6606 26 ) ) -RRB- cord-010119-t1x9gknd 6606 27 of of IN cord-010119-t1x9gknd 6606 28 PEG PEG NNP cord-010119-t1x9gknd 6606 29 and and CC cord-010119-t1x9gknd 6606 30 LISS LISS NNP cord-010119-t1x9gknd 6606 31 , , , cord-010119-t1x9gknd 6606 32 and and CC cord-010119-t1x9gknd 6606 33 to to TO cord-010119-t1x9gknd 6606 34 determine determine VB cord-010119-t1x9gknd 6606 35 the the DT cord-010119-t1x9gknd 6606 36 most most RBS cord-010119-t1x9gknd 6606 37 appropriate appropriate JJ cord-010119-t1x9gknd 6606 38 manual manual JJ cord-010119-t1x9gknd 6606 39 backup backup NN cord-010119-t1x9gknd 6606 40 method method NN cord-010119-t1x9gknd 6606 41 for for IN cord-010119-t1x9gknd 6606 42 the the DT cord-010119-t1x9gknd 6606 43 existing exist VBG cord-010119-t1x9gknd 6606 44 automated automate VBN cord-010119-t1x9gknd 6606 45 solid solid JJ cord-010119-t1x9gknd 6606 46 phase phase NN cord-010119-t1x9gknd 6606 47 system system NN cord-010119-t1x9gknd 6606 48 . . . cord-010119-t1x9gknd 6607 1 Study Study NNP cord-010119-t1x9gknd 6607 2 Design Design NNP cord-010119-t1x9gknd 6607 3 / / SYM cord-010119-t1x9gknd 6607 4 Method method NN cord-010119-t1x9gknd 6607 5 : : : cord-010119-t1x9gknd 6608 1 A a DT cord-010119-t1x9gknd 6608 2 total total NN cord-010119-t1x9gknd 6608 3 of of IN cord-010119-t1x9gknd 6608 4 202 202 CD cord-010119-t1x9gknd 6608 5 specimens specimen NNS cord-010119-t1x9gknd 6608 6 were be VBD cord-010119-t1x9gknd 6608 7 compared compare VBN cord-010119-t1x9gknd 6608 8 utilizing utilize VBG cord-010119-t1x9gknd 6608 9 : : : cord-010119-t1x9gknd 6608 10 automated automate VBN cord-010119-t1x9gknd 6608 11 solid solid JJ cord-010119-t1x9gknd 6608 12 phase phase NN cord-010119-t1x9gknd 6608 13 red red JJ cord-010119-t1x9gknd 6608 14 cell cell NN cord-010119-t1x9gknd 6608 15 adherence adherence NN cord-010119-t1x9gknd 6608 16 assay assay NN cord-010119-t1x9gknd 6608 17 ( ( -LRB- cord-010119-t1x9gknd 6608 18 SPRCA SPRCA NNP cord-010119-t1x9gknd 6608 19 ) ) -RRB- cord-010119-t1x9gknd 6608 20 with with IN cord-010119-t1x9gknd 6608 21 manual manual JJ cord-010119-t1x9gknd 6608 22 tube tube NN cord-010119-t1x9gknd 6608 23 PEG PEG NNP cord-010119-t1x9gknd 6608 24 and and CC cord-010119-t1x9gknd 6608 25 LISS LISS NNP cord-010119-t1x9gknd 6608 26 , , , cord-010119-t1x9gknd 6609 1 some some DT cord-010119-t1x9gknd 6609 2 samples sample NNS cord-010119-t1x9gknd 6609 3 were be VBD cord-010119-t1x9gknd 6609 4 not not RB cord-010119-t1x9gknd 6609 5 sufficient sufficient JJ cord-010119-t1x9gknd 6609 6 quantity quantity NN cord-010119-t1x9gknd 6609 7 to to TO cord-010119-t1x9gknd 6609 8 test test NN cord-010119-t1x9gknd 6609 9 in in IN cord-010119-t1x9gknd 6609 10 LISS LISS NNP cord-010119-t1x9gknd 6609 11 . . . cord-010119-t1x9gknd 6610 1 Identification identification NN cord-010119-t1x9gknd 6610 2 panels panel NNS cord-010119-t1x9gknd 6610 3 were be VBD cord-010119-t1x9gknd 6610 4 used use VBN cord-010119-t1x9gknd 6610 5 to to TO cord-010119-t1x9gknd 6610 6 determine determine VB cord-010119-t1x9gknd 6610 7 : : : cord-010119-t1x9gknd 6610 8 clinically clinically RB cord-010119-t1x9gknd 6610 9 significant significant JJ cord-010119-t1x9gknd 6610 10 antibodies antibody NNS cord-010119-t1x9gknd 6610 11 , , , cord-010119-t1x9gknd 6610 12 warm warm JJ cord-010119-t1x9gknd 6610 13 autoantibodies autoantibody NNS cord-010119-t1x9gknd 6610 14 , , , cord-010119-t1x9gknd 6610 15 and and CC cord-010119-t1x9gknd 6610 16 nonspecific nonspecific JJ cord-010119-t1x9gknd 6610 17 reactions reaction NNS cord-010119-t1x9gknd 6610 18 . . . cord-010119-t1x9gknd 6611 1 Calculations calculation NNS cord-010119-t1x9gknd 6611 2 were be VBD cord-010119-t1x9gknd 6611 3 based base VBN cord-010119-t1x9gknd 6611 4 upon upon IN cord-010119-t1x9gknd 6611 5 comparison comparison NN cord-010119-t1x9gknd 6611 6 to to IN cord-010119-t1x9gknd 6611 7 SPRCA SPRCA NNP cord-010119-t1x9gknd 6611 8 . . . cord-010119-t1x9gknd 6612 1 Results result NNS cord-010119-t1x9gknd 6612 2 / / SYM cord-010119-t1x9gknd 6612 3 Findings finding NNS cord-010119-t1x9gknd 6612 4 : : : cord-010119-t1x9gknd 6613 1 A a DT cord-010119-t1x9gknd 6613 2 total total NN cord-010119-t1x9gknd 6613 3 of of IN cord-010119-t1x9gknd 6613 4 164 164 CD cord-010119-t1x9gknd 6613 5 clinically clinically RB cord-010119-t1x9gknd 6613 6 significant significant JJ cord-010119-t1x9gknd 6613 7 antibodies antibody NNS cord-010119-t1x9gknd 6613 8 were be VBD cord-010119-t1x9gknd 6613 9 detected detect VBN cord-010119-t1x9gknd 6613 10 using use VBG cord-010119-t1x9gknd 6613 11 SPRCA SPRCA NNP cord-010119-t1x9gknd 6613 12 technique technique NN cord-010119-t1x9gknd 6613 13 , , , cord-010119-t1x9gknd 6613 14 as as RB cord-010119-t1x9gknd 6613 15 well well RB cord-010119-t1x9gknd 6613 16 as as IN cord-010119-t1x9gknd 6613 17 9 9 CD cord-010119-t1x9gknd 6613 18 warm warm JJ cord-010119-t1x9gknd 6613 19 autoantibodies autoantibody NNS cord-010119-t1x9gknd 6613 20 and and CC cord-010119-t1x9gknd 6613 21 97 97 CD cord-010119-t1x9gknd 6613 22 nonspecific nonspecific JJ cord-010119-t1x9gknd 6613 23 reactions reaction NNS cord-010119-t1x9gknd 6613 24 . . . cord-010119-t1x9gknd 6614 1 PEG PEG NNP cord-010119-t1x9gknd 6614 2 demonstrated demonstrate VBD cord-010119-t1x9gknd 6614 3 the the DT cord-010119-t1x9gknd 6614 4 highest high JJS cord-010119-t1x9gknd 6614 5 sensitivity sensitivity NN cord-010119-t1x9gknd 6614 6 and and CC cord-010119-t1x9gknd 6614 7 lowest low JJS cord-010119-t1x9gknd 6614 8 specificity specificity NN cord-010119-t1x9gknd 6614 9 while while IN cord-010119-t1x9gknd 6614 10 LISS LISS NNP cord-010119-t1x9gknd 6614 11 was be VBD cord-010119-t1x9gknd 6614 12 least least JJS cord-010119-t1x9gknd 6614 13 sensitive sensitive JJ cord-010119-t1x9gknd 6614 14 and and CC cord-010119-t1x9gknd 6614 15 most most RBS cord-010119-t1x9gknd 6614 16 specific specific JJ cord-010119-t1x9gknd 6614 17 for for IN cord-010119-t1x9gknd 6614 18 clinically clinically RB cord-010119-t1x9gknd 6614 19 significant significant JJ cord-010119-t1x9gknd 6614 20 antibodies antibody NNS cord-010119-t1x9gknd 6614 21 . . . cord-010119-t1x9gknd 6615 1 For for IN cord-010119-t1x9gknd 6615 2 warm warm JJ cord-010119-t1x9gknd 6615 3 autoantibodies autoantibody NNS cord-010119-t1x9gknd 6615 4 , , , cord-010119-t1x9gknd 6615 5 LISS LISS NNP cord-010119-t1x9gknd 6615 6 was be VBD cord-010119-t1x9gknd 6615 7 more more RBR cord-010119-t1x9gknd 6615 8 sensitive sensitive JJ cord-010119-t1x9gknd 6615 9 than than IN cord-010119-t1x9gknd 6615 10 PEG PEG NNP cord-010119-t1x9gknd 6615 11 with with IN cord-010119-t1x9gknd 6615 12 both both DT cord-010119-t1x9gknd 6615 13 being be VBG cord-010119-t1x9gknd 6615 14 100 100 CD cord-010119-t1x9gknd 6615 15 % % NN cord-010119-t1x9gknd 6615 16 specific specific JJ cord-010119-t1x9gknd 6615 17 . . . cord-010119-t1x9gknd 6616 1 Both both DT cord-010119-t1x9gknd 6616 2 reduced reduce VBD cord-010119-t1x9gknd 6616 3 the the DT cord-010119-t1x9gknd 6616 4 detection detection NN cord-010119-t1x9gknd 6616 5 of of IN cord-010119-t1x9gknd 6616 6 nonspecific nonspecific JJ cord-010119-t1x9gknd 6616 7 reactions reaction NNS cord-010119-t1x9gknd 6616 8 . . . cord-010119-t1x9gknd 6617 1 While while IN cord-010119-t1x9gknd 6617 2 PEG PEG NNP cord-010119-t1x9gknd 6617 3 had have VBD cord-010119-t1x9gknd 6617 4 more more RBR cord-010119-t1x9gknd 6617 5 nonspecific nonspecific JJ cord-010119-t1x9gknd 6617 6 reactions reaction NNS cord-010119-t1x9gknd 6617 7 ( ( -LRB- cord-010119-t1x9gknd 6617 8 30 30 CD cord-010119-t1x9gknd 6617 9 versus versus IN cord-010119-t1x9gknd 6617 10 13 13 CD cord-010119-t1x9gknd 6617 11 ) ) -RRB- cord-010119-t1x9gknd 6617 12 , , , cord-010119-t1x9gknd 6617 13 it -PRON- PRP cord-010119-t1x9gknd 6617 14 identified identify VBD cord-010119-t1x9gknd 6617 15 more more RBR cord-010119-t1x9gknd 6617 16 clinically clinically RB cord-010119-t1x9gknd 6617 17 significant significant JJ cord-010119-t1x9gknd 6617 18 antibodies antibody NNS cord-010119-t1x9gknd 6617 19 ( ( -LRB- cord-010119-t1x9gknd 6617 20 129 129 CD cord-010119-t1x9gknd 6617 21 ) ) -RRB- cord-010119-t1x9gknd 6617 22 than than IN cord-010119-t1x9gknd 6617 23 LISS LISS NNP cord-010119-t1x9gknd 6617 24 ( ( -LRB- cord-010119-t1x9gknd 6617 25 93 93 CD cord-010119-t1x9gknd 6617 26 ) ) -RRB- cord-010119-t1x9gknd 6617 27 . . . cord-010119-t1x9gknd 6618 1 ( ( -LRB- cord-010119-t1x9gknd 6618 2 Table table NN cord-010119-t1x9gknd 6618 3 ) ) -RRB- cord-010119-t1x9gknd 6619 1 Conclusion conclusion NN cord-010119-t1x9gknd 6619 2 : : : cord-010119-t1x9gknd 6619 3 Ultimately ultimately RB cord-010119-t1x9gknd 6619 4 , , , cord-010119-t1x9gknd 6619 5 the the DT cord-010119-t1x9gknd 6619 6 decision decision NN cord-010119-t1x9gknd 6619 7 to to TO cord-010119-t1x9gknd 6619 8 choose choose VB cord-010119-t1x9gknd 6619 9 a a DT cord-010119-t1x9gknd 6619 10 manual manual JJ cord-010119-t1x9gknd 6619 11 backup backup NN cord-010119-t1x9gknd 6619 12 method method NN cord-010119-t1x9gknd 6619 13 must must MD cord-010119-t1x9gknd 6619 14 be be VB cord-010119-t1x9gknd 6619 15 based base VBN cord-010119-t1x9gknd 6619 16 upon upon IN cord-010119-t1x9gknd 6619 17 the the DT cord-010119-t1x9gknd 6619 18 highest high JJS cord-010119-t1x9gknd 6619 19 sensitivity sensitivity NN cord-010119-t1x9gknd 6619 20 for for IN cord-010119-t1x9gknd 6619 21 clinical clinical JJ cord-010119-t1x9gknd 6619 22 significant significant JJ cord-010119-t1x9gknd 6619 23 antibodies antibody NNS cord-010119-t1x9gknd 6619 24 so so IN cord-010119-t1x9gknd 6619 25 as as IN cord-010119-t1x9gknd 6619 26 to to TO cord-010119-t1x9gknd 6619 27 minimize minimize VB cord-010119-t1x9gknd 6619 28 failure failure NN cord-010119-t1x9gknd 6619 29 to to TO cord-010119-t1x9gknd 6619 30 detect detect VB cord-010119-t1x9gknd 6619 31 one one CD cord-010119-t1x9gknd 6619 32 . . . cord-010119-t1x9gknd 6620 1 PEG PEG NNP cord-010119-t1x9gknd 6620 2 was be VBD cord-010119-t1x9gknd 6620 3 selected select VBN cord-010119-t1x9gknd 6620 4 as as IN cord-010119-t1x9gknd 6620 5 the the DT cord-010119-t1x9gknd 6620 6 backup backup JJ cord-010119-t1x9gknd 6620 7 manual manual JJ cord-010119-t1x9gknd 6620 8 method method NN cord-010119-t1x9gknd 6620 9 even even RB cord-010119-t1x9gknd 6620 10 though though IN cord-010119-t1x9gknd 6620 11 PEG PEG NNP cord-010119-t1x9gknd 6620 12 has have VBZ cord-010119-t1x9gknd 6620 13 a a DT cord-010119-t1x9gknd 6620 14 higher high JJR cord-010119-t1x9gknd 6620 15 sensitivity sensitivity NN cord-010119-t1x9gknd 6620 16 to to IN cord-010119-t1x9gknd 6620 17 nonspecific nonspecific JJ cord-010119-t1x9gknd 6620 18 reactions reaction NNS cord-010119-t1x9gknd 6620 19 . . . cord-010119-t1x9gknd 6621 1 This this DT cord-010119-t1x9gknd 6621 2 study study NN cord-010119-t1x9gknd 6621 3 clearly clearly RB cord-010119-t1x9gknd 6621 4 demonstrates demonstrate VBZ cord-010119-t1x9gknd 6621 5 the the DT cord-010119-t1x9gknd 6621 6 interplay interplay NN cord-010119-t1x9gknd 6621 7 and and CC cord-010119-t1x9gknd 6621 8 tradeoffs tradeoff NNS cord-010119-t1x9gknd 6621 9 between between IN cord-010119-t1x9gknd 6621 10 methods method NNS cord-010119-t1x9gknd 6621 11 , , , cord-010119-t1x9gknd 6621 12 which which WDT cord-010119-t1x9gknd 6621 13 are be VBP cord-010119-t1x9gknd 6621 14 important important JJ cord-010119-t1x9gknd 6621 15 to to TO cord-010119-t1x9gknd 6621 16 understand understand VB cord-010119-t1x9gknd 6621 17 and and CC cord-010119-t1x9gknd 6621 18 consider consider VB cord-010119-t1x9gknd 6621 19 when when WRB cord-010119-t1x9gknd 6621 20 making make VBG cord-010119-t1x9gknd 6621 21 method method NN cord-010119-t1x9gknd 6621 22 choice choice NN cord-010119-t1x9gknd 6621 23 decisions decision NNS cord-010119-t1x9gknd 6621 24 . . . cord-010119-t1x9gknd 6622 1 Comparison comparison NN cord-010119-t1x9gknd 6622 2 of of IN cord-010119-t1x9gknd 6622 3 Thiol Thiol NNP cord-010119-t1x9gknd 6622 4 Reagents Reagents NNPS cord-010119-t1x9gknd 6622 5 in in IN cord-010119-t1x9gknd 6622 6 Denaturing denature VBG cord-010119-t1x9gknd 6622 7 CD38 CD38 NNP cord-010119-t1x9gknd 6622 8 on on IN cord-010119-t1x9gknd 6622 9 RBCs rbc NNS cord-010119-t1x9gknd 6623 1 Patricia Patricia NNP cord-010119-t1x9gknd 6623 2 A a DT cord-010119-t1x9gknd 6623 3 Arndt Arndt NNP cord-010119-t1x9gknd 6623 4 * * NFP cord-010119-t1x9gknd 6623 5 1 1 CD cord-010119-t1x9gknd 6623 6 , , , cord-010119-t1x9gknd 6623 7 Anthony Anthony NNP cord-010119-t1x9gknd 6623 8 Salazar Salazar NNP cord-010119-t1x9gknd 6623 9 2 2 CD cord-010119-t1x9gknd 6623 10 and and CC cord-010119-t1x9gknd 6623 11 Regina Regina NNP cord-010119-t1x9gknd 6623 12 M. M. NNP cord-010119-t1x9gknd 6623 13 Leger Leger NNP cord-010119-t1x9gknd 6623 14 1 1 CD cord-010119-t1x9gknd 6623 15 . . . cord-010119-t1x9gknd 6623 16 1 1 CD cord-010119-t1x9gknd 6624 1 American American NNP cord-010119-t1x9gknd 6624 2 Red Red NNP cord-010119-t1x9gknd 6624 3 Cross Cross NNP cord-010119-t1x9gknd 6624 4 Blood Blood NNP cord-010119-t1x9gknd 6624 5 Services Services NNPS cord-010119-t1x9gknd 6624 6 , , , cord-010119-t1x9gknd 6624 7 2 2 CD cord-010119-t1x9gknd 6624 8 Long Long NNP cord-010119-t1x9gknd 6624 9 Beach Beach NNP cord-010119-t1x9gknd 6624 10 Memorial Memorial NNP cord-010119-t1x9gknd 6624 11 Medical Medical NNP cord-010119-t1x9gknd 6624 12 Center Center NNP cord-010119-t1x9gknd 6624 13 Background Background NNP cord-010119-t1x9gknd 6624 14 / / SYM cord-010119-t1x9gknd 6624 15 Case Case NNP cord-010119-t1x9gknd 6624 16 Studies Studies NNPS cord-010119-t1x9gknd 6624 17 : : : cord-010119-t1x9gknd 6624 18 Monoclonal monoclonal JJ cord-010119-t1x9gknd 6624 19 anti anti JJ cord-010119-t1x9gknd 6624 20 - - JJ cord-010119-t1x9gknd 6624 21 CD38 CD38 NNP cord-010119-t1x9gknd 6624 22 , , , cord-010119-t1x9gknd 6624 23 e.g. e.g. RB cord-010119-t1x9gknd 6624 24 , , , cord-010119-t1x9gknd 6624 25 daratumumab daratumumab NNP cord-010119-t1x9gknd 6624 26 ( ( -LRB- cord-010119-t1x9gknd 6624 27 DARA DARA NNP cord-010119-t1x9gknd 6624 28 ) ) -RRB- cord-010119-t1x9gknd 6624 29 , , , cord-010119-t1x9gknd 6624 30 which which WDT cord-010119-t1x9gknd 6624 31 is be VBZ cord-010119-t1x9gknd 6624 32 used use VBN cord-010119-t1x9gknd 6624 33 to to TO cord-010119-t1x9gknd 6624 34 treat treat VB cord-010119-t1x9gknd 6624 35 patients patient NNS cord-010119-t1x9gknd 6624 36 with with IN cord-010119-t1x9gknd 6624 37 multiple multiple JJ cord-010119-t1x9gknd 6624 38 myeloma myeloma NN cord-010119-t1x9gknd 6624 39 , , , cord-010119-t1x9gknd 6624 40 causes cause VBZ cord-010119-t1x9gknd 6624 41 positive positive JJ cord-010119-t1x9gknd 6624 42 indirect indirect JJ cord-010119-t1x9gknd 6624 43 antiglobulin antiglobulin NN cord-010119-t1x9gknd 6624 44 tests test NNS cord-010119-t1x9gknd 6624 45 ( ( -LRB- cord-010119-t1x9gknd 6624 46 IATs IATs NNP cord-010119-t1x9gknd 6624 47 ) ) -RRB- cord-010119-t1x9gknd 6624 48 due due IN cord-010119-t1x9gknd 6624 49 to to IN cord-010119-t1x9gknd 6624 50 expression expression NN cord-010119-t1x9gknd 6624 51 of of IN cord-010119-t1x9gknd 6624 52 CD38 CD38 NNP cord-010119-t1x9gknd 6624 53 on on IN cord-010119-t1x9gknd 6624 54 red red JJ cord-010119-t1x9gknd 6624 55 blood blood NN cord-010119-t1x9gknd 6624 56 cells cell NNS cord-010119-t1x9gknd 6624 57 ( ( -LRB- cord-010119-t1x9gknd 6624 58 RBCs rbc NNS cord-010119-t1x9gknd 6624 59 ) ) -RRB- cord-010119-t1x9gknd 6624 60 . . . cord-010119-t1x9gknd 6625 1 This this DT cord-010119-t1x9gknd 6625 2 serologic serologic JJ cord-010119-t1x9gknd 6625 3 reactivity reactivity NN cord-010119-t1x9gknd 6625 4 can can MD cord-010119-t1x9gknd 6625 5 not not RB cord-010119-t1x9gknd 6625 6 be be VB cord-010119-t1x9gknd 6625 7 removed remove VBN cord-010119-t1x9gknd 6625 8 by by IN cord-010119-t1x9gknd 6625 9 adsorption adsorption NN cord-010119-t1x9gknd 6625 10 so so IN cord-010119-t1x9gknd 6625 11 other other JJ cord-010119-t1x9gknd 6625 12 methods method NNS cord-010119-t1x9gknd 6625 13 have have VBP cord-010119-t1x9gknd 6625 14 been be VBN cord-010119-t1x9gknd 6625 15 developed develop VBN cord-010119-t1x9gknd 6625 16 to to TO cord-010119-t1x9gknd 6625 17 detect detect VB cord-010119-t1x9gknd 6625 18 / / SYM cord-010119-t1x9gknd 6625 19 identify identify VB cord-010119-t1x9gknd 6625 20 underlying underlying JJ cord-010119-t1x9gknd 6625 21 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6625 22 . . . cord-010119-t1x9gknd 6626 1 One one CD cord-010119-t1x9gknd 6626 2 popular popular JJ cord-010119-t1x9gknd 6626 3 method method NN cord-010119-t1x9gknd 6626 4 is be VBZ cord-010119-t1x9gknd 6626 5 to to TO cord-010119-t1x9gknd 6626 6 denature denature VB cord-010119-t1x9gknd 6626 7 the the DT cord-010119-t1x9gknd 6626 8 CD38 CD38 NNP cord-010119-t1x9gknd 6626 9 antigen antigen NN cord-010119-t1x9gknd 6626 10 by by IN cord-010119-t1x9gknd 6626 11 treatment treatment NN cord-010119-t1x9gknd 6626 12 of of IN cord-010119-t1x9gknd 6626 13 RBCs rbc NNS cord-010119-t1x9gknd 6626 14 with with IN cord-010119-t1x9gknd 6626 15 thiol thiol NN cord-010119-t1x9gknd 6626 16 reagents reagent NNS cord-010119-t1x9gknd 6626 17 , , , cord-010119-t1x9gknd 6626 18 e.g. e.g. RB cord-010119-t1x9gknd 6626 19 , , , cord-010119-t1x9gknd 6626 20 dithiothreitol dithiothreitol FW cord-010119-t1x9gknd 6626 21 ( ( -LRB- cord-010119-t1x9gknd 6626 22 DTT DTT NNP cord-010119-t1x9gknd 6626 23 ) ) -RRB- cord-010119-t1x9gknd 6626 24 or or CC cord-010119-t1x9gknd 6626 25 2aminoethylisothiouronium 2aminoethylisothiouronium CD cord-010119-t1x9gknd 6626 26 bromide bromide NN cord-010119-t1x9gknd 6626 27 ( ( -LRB- cord-010119-t1x9gknd 6626 28 AET AET NNP cord-010119-t1x9gknd 6626 29 ) ) -RRB- cord-010119-t1x9gknd 6626 30 . . . cord-010119-t1x9gknd 6627 1 Chapuy Chapuy NNP cord-010119-t1x9gknd 6627 2 et et NNP cord-010119-t1x9gknd 6627 3 al al NNP cord-010119-t1x9gknd 6627 4 described describe VBD cord-010119-t1x9gknd 6627 5 ( ( -LRB- cord-010119-t1x9gknd 6627 6 2015 2015 CD cord-010119-t1x9gknd 6627 7 ) ) -RRB- cord-010119-t1x9gknd 6627 8 and and CC cord-010119-t1x9gknd 6627 9 validated validate VBN cord-010119-t1x9gknd 6627 10 ( ( -LRB- cord-010119-t1x9gknd 6627 11 2016 2016 CD cord-010119-t1x9gknd 6627 12 ) ) -RRB- cord-010119-t1x9gknd 6627 13 2 2 CD cord-010119-t1x9gknd 6627 14 ) ) -RRB- cord-010119-t1x9gknd 6627 15 , , , cord-010119-t1x9gknd 6627 16 and and CC cord-010119-t1x9gknd 6627 17 6 6 CD cord-010119-t1x9gknd 6627 18 % % NN cord-010119-t1x9gknd 6627 19 AET aet NN cord-010119-t1x9gknd 6627 20 ( ( -LRB- cord-010119-t1x9gknd 6627 21 pH pH NNP cord-010119-t1x9gknd 6627 22 8.0 8.0 CD cord-010119-t1x9gknd 6627 23 ) ) -RRB- cord-010119-t1x9gknd 6627 24 as as IN cord-010119-t1x9gknd 6627 25 per per IN cord-010119-t1x9gknd 6627 26 the the DT cord-010119-t1x9gknd 6627 27 AABB AABB NNP cord-010119-t1x9gknd 6627 28 Technical Technical NNP cord-010119-t1x9gknd 6627 29 Manual Manual NNP cord-010119-t1x9gknd 6627 30 , , , cord-010119-t1x9gknd 6627 31 17th 17th JJ cord-010119-t1x9gknd 6627 32 ed ed NN cord-010119-t1x9gknd 6627 33 . . . cord-010119-t1x9gknd 6628 1 These these DT cord-010119-t1x9gknd 6628 2 treated treat VBN cord-010119-t1x9gknd 6628 3 and and CC cord-010119-t1x9gknd 6628 4 untreated untreated JJ cord-010119-t1x9gknd 6628 5 RBCs rbc NNS cord-010119-t1x9gknd 6628 6 were be VBD cord-010119-t1x9gknd 6628 7 stored store VBN cord-010119-t1x9gknd 6628 8 in in IN cord-010119-t1x9gknd 6628 9 Alsevers Alsevers NNP cord-010119-t1x9gknd 6628 10 at at IN cord-010119-t1x9gknd 6628 11 4C 4c CD cord-010119-t1x9gknd 6628 12 and and CC cord-010119-t1x9gknd 6628 13 tested test VBN cord-010119-t1x9gknd 6628 14 on on IN cord-010119-t1x9gknd 6628 15 days day NNS cord-010119-t1x9gknd 6628 16 1 1 CD cord-010119-t1x9gknd 6628 17 , , , cord-010119-t1x9gknd 6628 18 2 2 CD cord-010119-t1x9gknd 6628 19 , , , cord-010119-t1x9gknd 6628 20 4 4 CD cord-010119-t1x9gknd 6628 21 , , , cord-010119-t1x9gknd 6628 22 5 5 CD cord-010119-t1x9gknd 6628 23 and and CC cord-010119-t1x9gknd 6628 24 8 8 CD cord-010119-t1x9gknd 6628 25 by by IN cord-010119-t1x9gknd 6628 26 two two CD cord-010119-t1x9gknd 6628 27 methods method NNS cord-010119-t1x9gknd 6628 28 : : : cord-010119-t1x9gknd 6628 29 1 1 LS cord-010119-t1x9gknd 6628 30 ) ) -RRB- cord-010119-t1x9gknd 6628 31 polyethylene polyethylene NN cord-010119-t1x9gknd 6628 32 glycol glycol NN cord-010119-t1x9gknd 6628 33 ( ( -LRB- cord-010119-t1x9gknd 6628 34 PEG peg NN cord-010119-t1x9gknd 6628 35 ) ) -RRB- cord-010119-t1x9gknd 6628 36 IAT IAT NNP cord-010119-t1x9gknd 6628 37 using use VBG cord-010119-t1x9gknd 6628 38 plasma plasma NN cord-010119-t1x9gknd 6628 39 from from IN cord-010119-t1x9gknd 6628 40 two two CD cord-010119-t1x9gknd 6628 41 myeloma myeloma NN cord-010119-t1x9gknd 6628 42 patients patient NNS cord-010119-t1x9gknd 6628 43 who who WP cord-010119-t1x9gknd 6628 44 had have VBD cord-010119-t1x9gknd 6628 45 received receive VBN cord-010119-t1x9gknd 6628 46 DARA DARA NNP cord-010119-t1x9gknd 6628 47 ( ( -LRB- cord-010119-t1x9gknd 6628 48 plasmas plasma NNS cord-010119-t1x9gknd 6628 49 from from IN cord-010119-t1x9gknd 6628 50 8 8 CD cord-010119-t1x9gknd 6628 51 total total JJ cord-010119-t1x9gknd 6628 52 DARA DARA NNP cord-010119-t1x9gknd 6628 53 patients patient NNS cord-010119-t1x9gknd 6628 54 were be VBD cord-010119-t1x9gknd 6628 55 tested test VBN cord-010119-t1x9gknd 6628 56 with with IN cord-010119-t1x9gknd 6628 57 reactivity reactivity NN cord-010119-t1x9gknd 6628 58 5 5 CD cord-010119-t1x9gknd 6628 59 1 1 CD cord-010119-t1x9gknd 6628 60 - - SYM cord-010119-t1x9gknd 6628 61 31 31 CD cord-010119-t1x9gknd 6628 62 ) ) -RRB- cord-010119-t1x9gknd 6628 63 , , , cord-010119-t1x9gknd 6628 64 and and CC cord-010119-t1x9gknd 6628 65 2 2 LS cord-010119-t1x9gknd 6628 66 ) ) -RRB- cord-010119-t1x9gknd 6628 67 flow flow NN cord-010119-t1x9gknd 6628 68 cytometry cytometry NN cord-010119-t1x9gknd 6628 69 using use VBG cord-010119-t1x9gknd 6628 70 phycoerythrin phycoerythrin NN cord-010119-t1x9gknd 6628 71 ( ( -LRB- cord-010119-t1x9gknd 6629 1 PE)labeled PE)labeled NNP cord-010119-t1x9gknd 6629 2 anti anti NNP cord-010119-t1x9gknd 6629 3 - - NNP cord-010119-t1x9gknd 6629 4 CD38 CD38 NNP cord-010119-t1x9gknd 6629 5 . . . cord-010119-t1x9gknd 6629 6 RBCs rbc NNS cord-010119-t1x9gknd 6629 7 were be VBD cord-010119-t1x9gknd 6629 8 also also RB cord-010119-t1x9gknd 6629 9 tested test VBN cord-010119-t1x9gknd 6629 10 on on IN cord-010119-t1x9gknd 6629 11 days day NNS cord-010119-t1x9gknd 6629 12 1 1 CD cord-010119-t1x9gknd 6629 13 and and CC cord-010119-t1x9gknd 6629 14 5 5 CD cord-010119-t1x9gknd 6629 15 or or CC cord-010119-t1x9gknd 6629 16 8 8 CD cord-010119-t1x9gknd 6629 17 with with IN cord-010119-t1x9gknd 6629 18 a a DT cord-010119-t1x9gknd 6629 19 serum serum NN cord-010119-t1x9gknd 6629 20 containing contain VBG cord-010119-t1x9gknd 6629 21 anti anti JJ cord-010119-t1x9gknd 6629 22 - - JJ cord-010119-t1x9gknd 6629 23 k k NN cord-010119-t1x9gknd 6629 24 by by IN cord-010119-t1x9gknd 6629 25 PEG PEG NNP cord-010119-t1x9gknd 6629 26 IAT IAT NNP cord-010119-t1x9gknd 6629 27 . . . cord-010119-t1x9gknd 6630 1 Results result NNS cord-010119-t1x9gknd 6630 2 / / SYM cord-010119-t1x9gknd 6630 3 Findings finding NNS cord-010119-t1x9gknd 6630 4 : : : cord-010119-t1x9gknd 6631 1 The the DT cord-010119-t1x9gknd 6631 2 0.2 0.2 CD cord-010119-t1x9gknd 6631 3 M M NNP cord-010119-t1x9gknd 6631 4 DTT DTT NNP cord-010119-t1x9gknd 6631 5 in in IN cord-010119-t1x9gknd 6631 6 pH pH NNP cord-010119-t1x9gknd 6631 7 8.0 8.0 CD cord-010119-t1x9gknd 6631 8 PBS PBS NNP cord-010119-t1x9gknd 6631 9 had have VBD cord-010119-t1x9gknd 6631 10 a a DT cord-010119-t1x9gknd 6631 11 final final JJ cord-010119-t1x9gknd 6631 12 pH ph NN cord-010119-t1x9gknd 6631 13 of of IN cord-010119-t1x9gknd 6631 14 7.3 7.3 CD cord-010119-t1x9gknd 6631 15 and and CC cord-010119-t1x9gknd 6631 16 the the DT cord-010119-t1x9gknd 6631 17 pH ph NN cord-010119-t1x9gknd 6631 18 of of IN cord-010119-t1x9gknd 6631 19 the the DT cord-010119-t1x9gknd 6631 20 commercial commercial JJ cord-010119-t1x9gknd 6631 21 0.2 0.2 CD cord-010119-t1x9gknd 6631 22 M M NNP cord-010119-t1x9gknd 6631 23 DTT DTT NNP cord-010119-t1x9gknd 6631 24 was be VBD cord-010119-t1x9gknd 6631 25 6.5 6.5 CD cord-010119-t1x9gknd 6631 26 . . . cord-010119-t1x9gknd 6632 1 Results result NNS cord-010119-t1x9gknd 6632 2 are be VBP cord-010119-t1x9gknd 6632 3 in in IN cord-010119-t1x9gknd 6632 4 Table Table NNP cord-010119-t1x9gknd 6632 5 _SP cord-010119-t1x9gknd 6632 6 1 1 CD cord-010119-t1x9gknd 6632 7 ; ; : cord-010119-t1x9gknd 6632 8 flow flow VB cord-010119-t1x9gknd 6632 9 cytometry cytometry NN cord-010119-t1x9gknd 6632 10 results result NNS cord-010119-t1x9gknd 6632 11 from from IN cord-010119-t1x9gknd 6632 12 days day NNS cord-010119-t1x9gknd 6632 13 2 2 CD cord-010119-t1x9gknd 6632 14 , , , cord-010119-t1x9gknd 6632 15 4 4 CD cord-010119-t1x9gknd 6632 16 and and CC cord-010119-t1x9gknd 6632 17 5 5 CD cord-010119-t1x9gknd 6632 18 ( ( -LRB- cord-010119-t1x9gknd 6632 19 data datum NNS cord-010119-t1x9gknd 6632 20 not not RB cord-010119-t1x9gknd 6632 21 shown show VBN cord-010119-t1x9gknd 6632 22 ) ) -RRB- cord-010119-t1x9gknd 6632 23 were be VBD cord-010119-t1x9gknd 6632 24 similar similar JJ cord-010119-t1x9gknd 6632 25 to to IN cord-010119-t1x9gknd 6632 26 those those DT cord-010119-t1x9gknd 6632 27 from from IN cord-010119-t1x9gknd 6632 28 days day NNS cord-010119-t1x9gknd 6632 29 1 1 CD cord-010119-t1x9gknd 6632 30 and and CC cord-010119-t1x9gknd 6632 31 8 8 CD cord-010119-t1x9gknd 6632 32 . . . cord-010119-t1x9gknd 6633 1 RBCs rbc NNS cord-010119-t1x9gknd 6633 2 treated treat VBN cord-010119-t1x9gknd 6633 3 with with IN cord-010119-t1x9gknd 6633 4 0.2 0.2 CD cord-010119-t1x9gknd 6633 5 M M NNP cord-010119-t1x9gknd 6633 6 DTT DTT NNP cord-010119-t1x9gknd 6633 7 ( ( -LRB- cord-010119-t1x9gknd 6633 8 both both DT cord-010119-t1x9gknd 6633 9 sources source NNS cord-010119-t1x9gknd 6633 10 ) ) -RRB- cord-010119-t1x9gknd 6633 11 or or CC cord-010119-t1x9gknd 6633 12 AET AET NNP cord-010119-t1x9gknd 6633 13 were be VBD cord-010119-t1x9gknd 6633 14 nonreactive nonreactive JJ cord-010119-t1x9gknd 6633 15 with with IN cord-010119-t1x9gknd 6633 16 anti anti JJ cord-010119-t1x9gknd 6633 17 - - JJ cord-010119-t1x9gknd 6633 18 k k JJ cord-010119-t1x9gknd 6633 19 and and CC cord-010119-t1x9gknd 6633 20 plasma plasma NN cord-010119-t1x9gknd 6633 21 from from IN cord-010119-t1x9gknd 6633 22 all all DT cord-010119-t1x9gknd 6633 23 DARA DARA NNP cord-010119-t1x9gknd 6633 24 patients patient NNS cord-010119-t1x9gknd 6633 25 and and CC cord-010119-t1x9gknd 6633 26 gave give VBD cord-010119-t1x9gknd 6633 27 very very RB cord-010119-t1x9gknd 6633 28 low low JJ cord-010119-t1x9gknd 6633 29 results result NNS cord-010119-t1x9gknd 6633 30 ( ( -LRB- cord-010119-t1x9gknd 6633 31 % % NN cord-010119-t1x9gknd 6633 32 positive positive JJ cord-010119-t1x9gknd 6633 33 events event NNS cord-010119-t1x9gknd 6633 34 ) ) -RRB- cord-010119-t1x9gknd 6633 35 with with IN cord-010119-t1x9gknd 6633 36 PE PE NNP cord-010119-t1x9gknd 6633 37 anti anti NNP cord-010119-t1x9gknd 6633 38 - - NNP cord-010119-t1x9gknd 6633 39 CD38 CD38 NNP cord-010119-t1x9gknd 6633 40 by by IN cord-010119-t1x9gknd 6633 41 flow flow NN cord-010119-t1x9gknd 6633 42 cytometry cytometry NN cord-010119-t1x9gknd 6633 43 for for IN cord-010119-t1x9gknd 6633 44 up up IN cord-010119-t1x9gknd 6633 45 to to TO cord-010119-t1x9gknd 6633 46 8 8 CD cord-010119-t1x9gknd 6633 47 days day NNS cord-010119-t1x9gknd 6633 48 after after IN cord-010119-t1x9gknd 6633 49 treatment treatment NN cord-010119-t1x9gknd 6633 50 . . . cord-010119-t1x9gknd 6634 1 RBCs rbc NNS cord-010119-t1x9gknd 6634 2 treated treat VBN cord-010119-t1x9gknd 6634 3 with with IN cord-010119-t1x9gknd 6634 4 0.01 0.01 CD cord-010119-t1x9gknd 6634 5 M M NNP cord-010119-t1x9gknd 6634 6 DTT DTT NNP cord-010119-t1x9gknd 6634 7 reacted react VBD cord-010119-t1x9gknd 6634 8 similarly similarly RB cord-010119-t1x9gknd 6634 9 to to IN cord-010119-t1x9gknd 6634 10 untreated untreated JJ cord-010119-t1x9gknd 6634 11 RBCs rbc NNS cord-010119-t1x9gknd 6634 12 with with IN cord-010119-t1x9gknd 6634 13 anti anti JJ cord-010119-t1x9gknd 6634 14 - - JJ cord-010119-t1x9gknd 6634 15 k k NNP cord-010119-t1x9gknd 6634 16 and and CC cord-010119-t1x9gknd 6634 17 DARA DARA NNP cord-010119-t1x9gknd 6634 18 plasmas plasma NNS cord-010119-t1x9gknd 6634 19 , , , cord-010119-t1x9gknd 6634 20 and and CC cord-010119-t1x9gknd 6634 21 showed show VBD cord-010119-t1x9gknd 6634 22 only only RB cord-010119-t1x9gknd 6634 23 some some DT cord-010119-t1x9gknd 6634 24 weakening weakening NN cord-010119-t1x9gknd 6634 25 ( ( -LRB- cord-010119-t1x9gknd 6634 26 10 10 CD cord-010119-t1x9gknd 6634 27 - - SYM cord-010119-t1x9gknd 6634 28 30 30 CD cord-010119-t1x9gknd 6634 29 % % NN cord-010119-t1x9gknd 6634 30 ) ) -RRB- cord-010119-t1x9gknd 6634 31 of of IN cord-010119-t1x9gknd 6634 32 reactivity reactivity NN cord-010119-t1x9gknd 6634 33 with with IN cord-010119-t1x9gknd 6634 34 PE PE NNP cord-010119-t1x9gknd 6634 35 anti anti NNP cord-010119-t1x9gknd 6634 36 - - NNP cord-010119-t1x9gknd 6634 37 CD38 CD38 NNP cord-010119-t1x9gknd 6634 38 . . . cord-010119-t1x9gknd 6635 1 Background Background NNP cord-010119-t1x9gknd 6635 2 / / SYM cord-010119-t1x9gknd 6635 3 Case Case NNP cord-010119-t1x9gknd 6635 4 Studies Studies NNPS cord-010119-t1x9gknd 6635 5 : : : cord-010119-t1x9gknd 6635 6 Clinically clinically RB cord-010119-t1x9gknd 6635 7 significant significant JJ cord-010119-t1x9gknd 6635 8 hemolytic hemolytic JJ cord-010119-t1x9gknd 6635 9 disease disease NN cord-010119-t1x9gknd 6635 10 of of IN cord-010119-t1x9gknd 6635 11 the the DT cord-010119-t1x9gknd 6635 12 fetus fetus NN cord-010119-t1x9gknd 6635 13 and and CC cord-010119-t1x9gknd 6635 14 the the DT cord-010119-t1x9gknd 6635 15 newborn newborn NN cord-010119-t1x9gknd 6635 16 ( ( -LRB- cord-010119-t1x9gknd 6635 17 HDN HDN NNP cord-010119-t1x9gknd 6635 18 ) ) -RRB- cord-010119-t1x9gknd 6635 19 is be VBZ cord-010119-t1x9gknd 6635 20 often often RB cord-010119-t1x9gknd 6635 21 caused cause VBN cord-010119-t1x9gknd 6635 22 by by IN cord-010119-t1x9gknd 6635 23 feto feto NNP cord-010119-t1x9gknd 6635 24 - - HYPH cord-010119-t1x9gknd 6635 25 maternal maternal JJ cord-010119-t1x9gknd 6635 26 RhD rhd NN cord-010119-t1x9gknd 6635 27 incompatibility incompatibility NN cord-010119-t1x9gknd 6635 28 . . . cord-010119-t1x9gknd 6636 1 With with IN cord-010119-t1x9gknd 6636 2 the the DT cord-010119-t1x9gknd 6636 3 discovery discovery NN cord-010119-t1x9gknd 6636 4 1997 1997 CD cord-010119-t1x9gknd 6636 5 of of IN cord-010119-t1x9gknd 6636 6 cell cell NN cord-010119-t1x9gknd 6636 7 - - HYPH cord-010119-t1x9gknd 6636 8 free free JJ cord-010119-t1x9gknd 6636 9 fetal fetal JJ cord-010119-t1x9gknd 6636 10 DNA dna NN cord-010119-t1x9gknd 6636 11 ( ( -LRB- cord-010119-t1x9gknd 6636 12 ccfDNA ccfDNA NNP cord-010119-t1x9gknd 6636 13 ) ) -RRB- cord-010119-t1x9gknd 6636 14 in in IN cord-010119-t1x9gknd 6636 15 maternal maternal JJ cord-010119-t1x9gknd 6636 16 plasma plasma NN cord-010119-t1x9gknd 6636 17 , , , cord-010119-t1x9gknd 6636 18 it -PRON- PRP cord-010119-t1x9gknd 6636 19 became become VBD cord-010119-t1x9gknd 6636 20 possible possible JJ cord-010119-t1x9gknd 6636 21 to to TO cord-010119-t1x9gknd 6636 22 determine determine VB cord-010119-t1x9gknd 6636 23 the the DT cord-010119-t1x9gknd 6636 24 RHD RHD NNP cord-010119-t1x9gknd 6636 25 genotype genotype NN cord-010119-t1x9gknd 6636 26 of of IN cord-010119-t1x9gknd 6636 27 the the DT cord-010119-t1x9gknd 6636 28 fetus fetus NN cord-010119-t1x9gknd 6636 29 using use VBG cord-010119-t1x9gknd 6636 30 non non JJ cord-010119-t1x9gknd 6636 31 - - JJ cord-010119-t1x9gknd 6636 32 invasive invasive JJ cord-010119-t1x9gknd 6636 33 techniques technique NNS cord-010119-t1x9gknd 6636 34 . . . cord-010119-t1x9gknd 6637 1 However however RB cord-010119-t1x9gknd 6637 2 , , , cord-010119-t1x9gknd 6637 3 the the DT cord-010119-t1x9gknd 6637 4 reliability reliability NN cord-010119-t1x9gknd 6637 5 of of IN cord-010119-t1x9gknd 6637 6 the the DT cord-010119-t1x9gknd 6637 7 non non JJ cord-010119-t1x9gknd 6637 8 - - JJ cord-010119-t1x9gknd 6637 9 invasive invasive JJ cord-010119-t1x9gknd 6637 10 prenatal prenatal JJ cord-010119-t1x9gknd 6637 11 RHD rhd NN cord-010119-t1x9gknd 6637 12 test test NN cord-010119-t1x9gknd 6637 13 ( ( -LRB- cord-010119-t1x9gknd 6637 14 NIP NIP NNP cord-010119-t1x9gknd 6637 15 RHD RHD NNP cord-010119-t1x9gknd 6637 16 ) ) -RRB- cord-010119-t1x9gknd 6637 17 is be VBZ cord-010119-t1x9gknd 6637 18 dependent dependent JJ cord-010119-t1x9gknd 6637 19 on on IN cord-010119-t1x9gknd 6637 20 sufficient sufficient JJ cord-010119-t1x9gknd 6637 21 amounts amount NNS cord-010119-t1x9gknd 6637 22 of of IN cord-010119-t1x9gknd 6637 23 cffDNA cffdna NN cord-010119-t1x9gknd 6637 24 in in IN cord-010119-t1x9gknd 6637 25 the the DT cord-010119-t1x9gknd 6637 26 maternal maternal JJ cord-010119-t1x9gknd 6637 27 plasma plasma NN cord-010119-t1x9gknd 6637 28 sample sample NN cord-010119-t1x9gknd 6637 29 . . . cord-010119-t1x9gknd 6638 1 Recent recent JJ cord-010119-t1x9gknd 6638 2 studies study NNS cord-010119-t1x9gknd 6638 3 show show VBP cord-010119-t1x9gknd 6638 4 that that IN cord-010119-t1x9gknd 6638 5 the the DT cord-010119-t1x9gknd 6638 6 fraction fraction NN cord-010119-t1x9gknd 6638 7 of of IN cord-010119-t1x9gknd 6638 8 ccfDNA ccfdna NN cord-010119-t1x9gknd 6638 9 in in IN cord-010119-t1x9gknd 6638 10 maternal maternal JJ cord-010119-t1x9gknd 6638 11 plasma plasma NN cord-010119-t1x9gknd 6638 12 varies vary VBZ cord-010119-t1x9gknd 6638 13 significantly significantly RB cord-010119-t1x9gknd 6638 14 between between IN cord-010119-t1x9gknd 6638 15 pregnant pregnant JJ cord-010119-t1x9gknd 6638 16 women woman NNS cord-010119-t1x9gknd 6638 17 and and CC cord-010119-t1x9gknd 6638 18 is be VBZ cord-010119-t1x9gknd 6638 19 inversely inversely RB cord-010119-t1x9gknd 6638 20 related relate VBN cord-010119-t1x9gknd 6638 21 to to IN cord-010119-t1x9gknd 6638 22 maternal maternal JJ cord-010119-t1x9gknd 6638 23 body body NN cord-010119-t1x9gknd 6638 24 mass mass NN cord-010119-t1x9gknd 6638 25 index index NN cord-010119-t1x9gknd 6638 26 ( ( -LRB- cord-010119-t1x9gknd 6638 27 BMI BMI NNP cord-010119-t1x9gknd 6638 28 ) ) -RRB- cord-010119-t1x9gknd 6638 29 . . . cord-010119-t1x9gknd 6639 1 Thus thus RB cord-010119-t1x9gknd 6639 2 , , , cord-010119-t1x9gknd 6639 3 high high JJ cord-010119-t1x9gknd 6639 4 maternal maternal JJ cord-010119-t1x9gknd 6639 5 BMI bmi NN cord-010119-t1x9gknd 6639 6 , , , cord-010119-t1x9gknd 6639 7 may may MD cord-010119-t1x9gknd 6639 8 impair impair VB cord-010119-t1x9gknd 6639 9 the the DT cord-010119-t1x9gknd 6639 10 validity validity NN cord-010119-t1x9gknd 6639 11 of of IN cord-010119-t1x9gknd 6639 12 NIP NIP NNP cord-010119-t1x9gknd 6639 13 RHD RHD NNP cord-010119-t1x9gknd 6639 14 . . . cord-010119-t1x9gknd 6640 1 The the DT cord-010119-t1x9gknd 6640 2 aim aim NN cord-010119-t1x9gknd 6640 3 of of IN cord-010119-t1x9gknd 6640 4 this this DT cord-010119-t1x9gknd 6640 5 study study NN cord-010119-t1x9gknd 6640 6 was be VBD cord-010119-t1x9gknd 6640 7 to to TO cord-010119-t1x9gknd 6640 8 examine examine VB cord-010119-t1x9gknd 6640 9 the the DT cord-010119-t1x9gknd 6640 10 effect effect NN cord-010119-t1x9gknd 6640 11 of of IN cord-010119-t1x9gknd 6640 12 maternal maternal JJ cord-010119-t1x9gknd 6640 13 BMI bmi NN cord-010119-t1x9gknd 6640 14 on on IN cord-010119-t1x9gknd 6640 15 the the DT cord-010119-t1x9gknd 6640 16 correctness correctness NN cord-010119-t1x9gknd 6640 17 of of IN cord-010119-t1x9gknd 6640 18 NIP NIP NNP cord-010119-t1x9gknd 6640 19 RHD RHD NNP cord-010119-t1x9gknd 6640 20 and and CC cord-010119-t1x9gknd 6640 21 the the DT cord-010119-t1x9gknd 6640 22 correlation correlation NN cord-010119-t1x9gknd 6640 23 of of IN cord-010119-t1x9gknd 6640 24 maternal maternal JJ cord-010119-t1x9gknd 6640 25 BMI bmi NN cord-010119-t1x9gknd 6640 26 with with IN cord-010119-t1x9gknd 6640 27 fraction fraction NN cord-010119-t1x9gknd 6640 28 of of IN cord-010119-t1x9gknd 6640 29 ccfDNA ccfdna NN cord-010119-t1x9gknd 6640 30 to to TO cord-010119-t1x9gknd 6640 31 total total VB cord-010119-t1x9gknd 6640 32 free free JJ cord-010119-t1x9gknd 6640 33 DNA dna NN cord-010119-t1x9gknd 6640 34 in in IN cord-010119-t1x9gknd 6640 35 the the DT cord-010119-t1x9gknd 6640 36 sample sample NN cord-010119-t1x9gknd 6640 37 . . . cord-010119-t1x9gknd 6641 1 Study Study NNP cord-010119-t1x9gknd 6641 2 Design Design NNP cord-010119-t1x9gknd 6641 3 / / SYM cord-010119-t1x9gknd 6641 4 Method method NN cord-010119-t1x9gknd 6641 5 : : : cord-010119-t1x9gknd 6642 1 Measurements measurement NNS cord-010119-t1x9gknd 6642 2 of of IN cord-010119-t1x9gknd 6642 3 body body NN cord-010119-t1x9gknd 6642 4 height height NN cord-010119-t1x9gknd 6642 5 and and CC cord-010119-t1x9gknd 6642 6 weight weight NN cord-010119-t1x9gknd 6642 7 of of IN cord-010119-t1x9gknd 6642 8 pregnant pregnant JJ cord-010119-t1x9gknd 6642 9 RhD rhd NN cord-010119-t1x9gknd 6642 10 negative negative JJ cord-010119-t1x9gknd 6642 11 women woman NNS cord-010119-t1x9gknd 6642 12 in in IN cord-010119-t1x9gknd 6642 13 gestational gestational JJ cord-010119-t1x9gknd 6642 14 week week NN cord-010119-t1x9gknd 6642 15 12 12 CD cord-010119-t1x9gknd 6642 16 were be VBD cord-010119-t1x9gknd 6642 17 obtained obtain VBN cord-010119-t1x9gknd 6642 18 from from IN cord-010119-t1x9gknd 6642 19 patient patient JJ cord-010119-t1x9gknd 6642 20 records record NNS cord-010119-t1x9gknd 6642 21 and and CC cord-010119-t1x9gknd 6642 22 used use VBN cord-010119-t1x9gknd 6642 23 for for IN cord-010119-t1x9gknd 6642 24 the the DT cord-010119-t1x9gknd 6642 25 calculation calculation NN cord-010119-t1x9gknd 6642 26 of of IN cord-010119-t1x9gknd 6642 27 maternal maternal JJ cord-010119-t1x9gknd 6642 28 BMI bmi NN cord-010119-t1x9gknd 6642 29 . . . cord-010119-t1x9gknd 6643 1 Data datum NNS cord-010119-t1x9gknd 6643 2 on on IN cord-010119-t1x9gknd 6643 3 BMI BMI NNP cord-010119-t1x9gknd 6643 4 were be VBD cord-010119-t1x9gknd 6643 5 combined combine VBN cord-010119-t1x9gknd 6643 6 with with IN cord-010119-t1x9gknd 6643 7 the the DT cord-010119-t1x9gknd 6643 8 results result NNS cord-010119-t1x9gknd 6643 9 from from IN cord-010119-t1x9gknd 6643 10 NIP NIP NNP cord-010119-t1x9gknd 6643 11 RHD RHD NNP cord-010119-t1x9gknd 6643 12 ( ( -LRB- cord-010119-t1x9gknd 6643 13 real real JJ cord-010119-t1x9gknd 6643 14 - - HYPH cord-010119-t1x9gknd 6643 15 time time NN cord-010119-t1x9gknd 6643 16 PCR PCR NNP cord-010119-t1x9gknd 6643 17 targeting target VBG cord-010119-t1x9gknd 6643 18 RHD RHD NNP cord-010119-t1x9gknd 6643 19 exon exon NN cord-010119-t1x9gknd 6643 20 5 5 CD cord-010119-t1x9gknd 6643 21 and and CC cord-010119-t1x9gknd 6643 22 10 10 CD cord-010119-t1x9gknd 6643 23 ) ) -RRB- cord-010119-t1x9gknd 6643 24 and and CC cord-010119-t1x9gknd 6643 25 sample sample NN cord-010119-t1x9gknd 6643 26 fraction fraction NN cord-010119-t1x9gknd 6643 27 of of IN cord-010119-t1x9gknd 6643 28 ccfDNA ccfDNA NNP cord-010119-t1x9gknd 6643 29 ( ( -LRB- cord-010119-t1x9gknd 6643 30 measured measure VBN cord-010119-t1x9gknd 6643 31 as as IN cord-010119-t1x9gknd 6643 32 threshold threshold NN cord-010119-t1x9gknd 6643 33 cycle cycle NN cord-010119-t1x9gknd 6643 34 [ [ -LRB- cord-010119-t1x9gknd 6643 35 Ct Ct NNP cord-010119-t1x9gknd 6643 36 ] ] -RRB- cord-010119-t1x9gknd 6643 37 value value NN cord-010119-t1x9gknd 6643 38 of of IN cord-010119-t1x9gknd 6643 39 RHD RHD NNP cord-010119-t1x9gknd 6643 40 ) ) -RRB- cord-010119-t1x9gknd 6643 41 to to TO cord-010119-t1x9gknd 6643 42 total total VB cord-010119-t1x9gknd 6643 43 free free JJ cord-010119-t1x9gknd 6643 44 DNA dna NN cord-010119-t1x9gknd 6643 45 ( ( -LRB- cord-010119-t1x9gknd 6643 46 measured measure VBN cord-010119-t1x9gknd 6643 47 as as IN cord-010119-t1x9gknd 6643 48 Ct Ct NNP cord-010119-t1x9gknd 6643 49 of of IN cord-010119-t1x9gknd 6643 50 CCR5 CCR5 NNP cord-010119-t1x9gknd 6643 51 ) ) -RRB- cord-010119-t1x9gknd 6643 52 in in IN cord-010119-t1x9gknd 6643 53 gestational gestational JJ cord-010119-t1x9gknd 6643 54 week week NN cord-010119-t1x9gknd 6643 55 25 25 CD cord-010119-t1x9gknd 6643 56 . . . cord-010119-t1x9gknd 6644 1 The the DT cord-010119-t1x9gknd 6644 2 correctness correctness NN cord-010119-t1x9gknd 6644 3 of of IN cord-010119-t1x9gknd 6644 4 NIP NIP NNP cord-010119-t1x9gknd 6644 5 RHD RHD NNP cord-010119-t1x9gknd 6644 6 was be VBD cord-010119-t1x9gknd 6644 7 determined determine VBN cord-010119-t1x9gknd 6644 8 by by IN cord-010119-t1x9gknd 6644 9 correlation correlation NN cord-010119-t1x9gknd 6644 10 with with IN cord-010119-t1x9gknd 6644 11 postnatal postnatal JJ cord-010119-t1x9gknd 6644 12 serological serological JJ cord-010119-t1x9gknd 6644 13 RhD rhd NN cord-010119-t1x9gknd 6644 14 determination determination NN cord-010119-t1x9gknd 6644 15 . . . cord-010119-t1x9gknd 6645 1 Results result NNS cord-010119-t1x9gknd 6645 2 / / SYM cord-010119-t1x9gknd 6645 3 Finding finding NN cord-010119-t1x9gknd 6645 4 : : : cord-010119-t1x9gknd 6645 5 A a DT cord-010119-t1x9gknd 6645 6 total total NN cord-010119-t1x9gknd 6645 7 of of IN cord-010119-t1x9gknd 6645 8 1618 1618 CD cord-010119-t1x9gknd 6645 9 pregnant pregnant JJ cord-010119-t1x9gknd 6645 10 women woman NNS cord-010119-t1x9gknd 6645 11 were be VBD cord-010119-t1x9gknd 6645 12 included include VBN cord-010119-t1x9gknd 6645 13 . . . cord-010119-t1x9gknd 6646 1 NIP NIP NNP cord-010119-t1x9gknd 6646 2 RHD RHD NNP cord-010119-t1x9gknd 6646 3 was be VBD cord-010119-t1x9gknd 6646 4 positive positive JJ cord-010119-t1x9gknd 6646 5 in in IN cord-010119-t1x9gknd 6646 6 987/1618 987/1618 CD cord-010119-t1x9gknd 6646 7 ( ( -LRB- cord-010119-t1x9gknd 6646 8 61 61 CD cord-010119-t1x9gknd 6646 9 % % NN cord-010119-t1x9gknd 6646 10 ) ) -RRB- cord-010119-t1x9gknd 6646 11 , , , cord-010119-t1x9gknd 6646 12 negative negative JJ cord-010119-t1x9gknd 6646 13 in in IN cord-010119-t1x9gknd 6646 14 582/1618 582/1618 CD cord-010119-t1x9gknd 6646 15 ( ( -LRB- cord-010119-t1x9gknd 6646 16 36 36 CD cord-010119-t1x9gknd 6646 17 % % NN cord-010119-t1x9gknd 6646 18 ) ) -RRB- cord-010119-t1x9gknd 6646 19 and and CC cord-010119-t1x9gknd 6646 20 inconclusive inconclusive JJ cord-010119-t1x9gknd 6646 21 in in IN cord-010119-t1x9gknd 6646 22 49/1618 49/1618 CD cord-010119-t1x9gknd 6646 23 ( ( -LRB- cord-010119-t1x9gknd 6646 24 3.0 3.0 CD cord-010119-t1x9gknd 6646 25 % % NN cord-010119-t1x9gknd 6646 26 ) ) -RRB- cord-010119-t1x9gknd 6646 27 . . . cord-010119-t1x9gknd 6647 1 Compared compare VBN cord-010119-t1x9gknd 6647 2 to to IN cord-010119-t1x9gknd 6647 3 the the DT cord-010119-t1x9gknd 6647 4 postnatal postnatal JJ cord-010119-t1x9gknd 6647 5 RhD rhd NN cord-010119-t1x9gknd 6647 6 type type NN cord-010119-t1x9gknd 6647 7 , , , cord-010119-t1x9gknd 6647 8 9/987 9/987 CD cord-010119-t1x9gknd 6647 9 ( ( -LRB- cord-010119-t1x9gknd 6647 10 0.1 0.1 CD cord-010119-t1x9gknd 6647 11 % % NN cord-010119-t1x9gknd 6647 12 ) ) -RRB- cord-010119-t1x9gknd 6647 13 of of IN cord-010119-t1x9gknd 6647 14 NIP NIP NNP cord-010119-t1x9gknd 6647 15 RHD RHD NNP cord-010119-t1x9gknd 6647 16 results result NNS cord-010119-t1x9gknd 6647 17 were be VBD cord-010119-t1x9gknd 6647 18 false false JJ cord-010119-t1x9gknd 6647 19 positive positive JJ cord-010119-t1x9gknd 6647 20 ( ( -LRB- cord-010119-t1x9gknd 6647 21 FP FP NNP cord-010119-t1x9gknd 6647 22 ) ) -RRB- cord-010119-t1x9gknd 6647 23 and and CC cord-010119-t1x9gknd 6647 24 4/582 4/582 CD cord-010119-t1x9gknd 6647 25 ( ( -LRB- cord-010119-t1x9gknd 6647 26 0.7 0.7 CD cord-010119-t1x9gknd 6647 27 % % NN cord-010119-t1x9gknd 6647 28 ) ) -RRB- cord-010119-t1x9gknd 6647 29 were be VBD cord-010119-t1x9gknd 6647 30 false false JJ cord-010119-t1x9gknd 6647 31 negative negative JJ cord-010119-t1x9gknd 6647 32 . . . cord-010119-t1x9gknd 6648 1 In in IN cord-010119-t1x9gknd 6648 2 5/49 5/49 CD cord-010119-t1x9gknd 6648 3 ( ( -LRB- cord-010119-t1x9gknd 6648 4 10 10 CD cord-010119-t1x9gknd 6648 5 % % NN cord-010119-t1x9gknd 6648 6 ) ) -RRB- cord-010119-t1x9gknd 6648 7 of of IN cord-010119-t1x9gknd 6648 8 inconclusive inconclusive JJ cord-010119-t1x9gknd 6648 9 NIP NIP NNP cord-010119-t1x9gknd 6648 10 RHD RHD NNP cord-010119-t1x9gknd 6648 11 , , , cord-010119-t1x9gknd 6648 12 the the DT cord-010119-t1x9gknd 6648 13 postnatal postnatal JJ cord-010119-t1x9gknd 6648 14 RhD rhd NN cord-010119-t1x9gknd 6648 15 type type NN cord-010119-t1x9gknd 6648 16 was be VBD cord-010119-t1x9gknd 6648 17 positive positive JJ cord-010119-t1x9gknd 6648 18 . . . cord-010119-t1x9gknd 6649 1 Mean mean JJ cord-010119-t1x9gknd 6649 2 BMI BMI NNP cord-010119-t1x9gknd 6649 3 ( ( -LRB- cord-010119-t1x9gknd 6649 4 n51618 n51618 NNP cord-010119-t1x9gknd 6649 5 ) ) -RRB- cord-010119-t1x9gknd 6649 6 at at IN cord-010119-t1x9gknd 6649 7 gestational gestational JJ cord-010119-t1x9gknd 6649 8 week week NN cord-010119-t1x9gknd 6649 9 12 12 CD cord-010119-t1x9gknd 6649 10 was be VBD cord-010119-t1x9gknd 6649 11 25.3 25.3 CD cord-010119-t1x9gknd 6649 12 ( ( -LRB- cord-010119-t1x9gknd 6649 13 10-and 10-and CD cord-010119-t1x9gknd 6649 14 90-percentiles 90-percentiles CD cord-010119-t1x9gknd 6649 15 : : : cord-010119-t1x9gknd 6649 16 20.0 20.0 CD cord-010119-t1x9gknd 6649 17 -32.4 -32.4 CD cord-010119-t1x9gknd 6649 18 ) ) -RRB- cord-010119-t1x9gknd 6649 19 . . . cord-010119-t1x9gknd 6650 1 There there EX cord-010119-t1x9gknd 6650 2 was be VBD cord-010119-t1x9gknd 6650 3 no no DT cord-010119-t1x9gknd 6650 4 difference difference NN cord-010119-t1x9gknd 6650 5 in in IN cord-010119-t1x9gknd 6650 6 mean mean JJ cord-010119-t1x9gknd 6650 7 BMI bmi NN cord-010119-t1x9gknd 6650 8 between between IN cord-010119-t1x9gknd 6650 9 individuals individual NNS cord-010119-t1x9gknd 6650 10 who who WP cord-010119-t1x9gknd 6650 11 tested test VBD cord-010119-t1x9gknd 6650 12 inconclusive inconclusive JJ cord-010119-t1x9gknd 6650 13 or or CC cord-010119-t1x9gknd 6650 14 false false JJ cord-010119-t1x9gknd 6650 15 negative negative NN cord-010119-t1x9gknd 6650 16 by by IN cord-010119-t1x9gknd 6650 17 NIP NIP NNP cord-010119-t1x9gknd 6650 18 RHD RHD NNP cord-010119-t1x9gknd 6650 19 compared compare VBN cord-010119-t1x9gknd 6650 20 to to IN cord-010119-t1x9gknd 6650 21 the the DT cord-010119-t1x9gknd 6650 22 remainder remainder NN cord-010119-t1x9gknd 6650 23 ( ( -LRB- cord-010119-t1x9gknd 6650 24 p50,71 p50,71 NNP cord-010119-t1x9gknd 6650 25 ) ) -RRB- cord-010119-t1x9gknd 6650 26 . . . cord-010119-t1x9gknd 6651 1 The the DT cord-010119-t1x9gknd 6651 2 fraction fraction NN cord-010119-t1x9gknd 6651 3 of of IN cord-010119-t1x9gknd 6651 4 ccfDNA ccfDNA NNP cord-010119-t1x9gknd 6651 5 was be VBD cord-010119-t1x9gknd 6651 6 calculated calculate VBN cord-010119-t1x9gknd 6651 7 for for IN cord-010119-t1x9gknd 6651 8 150 150 CD cord-010119-t1x9gknd 6651 9 randomly randomly RB cord-010119-t1x9gknd 6651 10 selected select VBN cord-010119-t1x9gknd 6651 11 NIP NIP NNP cord-010119-t1x9gknd 6651 12 RHD RHD NNP cord-010119-t1x9gknd 6651 13 true true JJ cord-010119-t1x9gknd 6651 14 positive positive JJ cord-010119-t1x9gknd 6651 15 cases case NNS cord-010119-t1x9gknd 6651 16 . . . cord-010119-t1x9gknd 6652 1 Median median JJ cord-010119-t1x9gknd 6652 2 ccfDNA ccfdna NN cord-010119-t1x9gknd 6652 3 ratio ratio NN cord-010119-t1x9gknd 6652 4 was be VBD cord-010119-t1x9gknd 6652 5 5.47 5.47 CD cord-010119-t1x9gknd 6653 1 ( ( -LRB- cord-010119-t1x9gknd 6653 2 the the DT cord-010119-t1x9gknd 6653 3 distribution distribution NN cord-010119-t1x9gknd 6653 4 had have VBD cord-010119-t1x9gknd 6653 5 a a DT cord-010119-t1x9gknd 6653 6 highly highly RB cord-010119-t1x9gknd 6653 7 positive positive JJ cord-010119-t1x9gknd 6653 8 skew skew NN cord-010119-t1x9gknd 6653 9 , , , cord-010119-t1x9gknd 6653 10 10-and 10-and CD cord-010119-t1x9gknd 6653 11 90-percentiles 90-percentiles CD cord-010119-t1x9gknd 6653 12 : : : cord-010119-t1x9gknd 6654 1 0.64 0.64 CD cord-010119-t1x9gknd 6654 2 -27.2 -27.2 CD cord-010119-t1x9gknd 6654 3 ) ) -RRB- cord-010119-t1x9gknd 6654 4 . . . cord-010119-t1x9gknd 6655 1 There there EX cord-010119-t1x9gknd 6655 2 was be VBD cord-010119-t1x9gknd 6655 3 no no DT cord-010119-t1x9gknd 6655 4 statistical statistical JJ cord-010119-t1x9gknd 6655 5 correlation correlation NN cord-010119-t1x9gknd 6655 6 between between IN cord-010119-t1x9gknd 6655 7 BMI BMI NNP cord-010119-t1x9gknd 6655 8 and and CC cord-010119-t1x9gknd 6655 9 fraction fraction NN cord-010119-t1x9gknd 6655 10 of of IN cord-010119-t1x9gknd 6655 11 ccfDNA ccfDNA NNP cord-010119-t1x9gknd 6655 12 to to TO cord-010119-t1x9gknd 6655 13 total total VB cord-010119-t1x9gknd 6655 14 free free JJ cord-010119-t1x9gknd 6655 15 DNA dna NN cord-010119-t1x9gknd 6655 16 ( ( -LRB- cord-010119-t1x9gknd 6655 17 r2 r2 NNP cord-010119-t1x9gknd 6655 18 50,012 50,012 CD cord-010119-t1x9gknd 6655 19 ; ; : cord-010119-t1x9gknd 6655 20 p50.49 p50.49 NNP cord-010119-t1x9gknd 6655 21 ) ) -RRB- cord-010119-t1x9gknd 6655 22 . . . cord-010119-t1x9gknd 6656 1 Conclusion conclusion NN cord-010119-t1x9gknd 6656 2 : : : cord-010119-t1x9gknd 6657 1 Neither neither CC cord-010119-t1x9gknd 6657 2 the the DT cord-010119-t1x9gknd 6657 3 correctness correctness NN cord-010119-t1x9gknd 6657 4 of of IN cord-010119-t1x9gknd 6657 5 NIP NIP NNP cord-010119-t1x9gknd 6657 6 RHD RHD NNP cord-010119-t1x9gknd 6657 7 test test NN cord-010119-t1x9gknd 6657 8 result result NN cord-010119-t1x9gknd 6657 9 nor nor CC cord-010119-t1x9gknd 6657 10 the the DT cord-010119-t1x9gknd 6657 11 fraction fraction NN cord-010119-t1x9gknd 6657 12 of of IN cord-010119-t1x9gknd 6657 13 cffDNA cffdna NN cord-010119-t1x9gknd 6657 14 to to TO cord-010119-t1x9gknd 6657 15 total total VB cord-010119-t1x9gknd 6657 16 free free JJ cord-010119-t1x9gknd 6657 17 DNA dna NN cord-010119-t1x9gknd 6657 18 appear appear VBP cord-010119-t1x9gknd 6657 19 to to TO cord-010119-t1x9gknd 6657 20 be be VB cord-010119-t1x9gknd 6657 21 correlated correlate VBN cord-010119-t1x9gknd 6657 22 to to IN cord-010119-t1x9gknd 6657 23 maternal maternal JJ cord-010119-t1x9gknd 6657 24 BMI BMI NNP cord-010119-t1x9gknd 6657 25 with with IN cord-010119-t1x9gknd 6657 26 regard regard NN cord-010119-t1x9gknd 6657 27 to to IN cord-010119-t1x9gknd 6657 28 maternal maternal JJ cord-010119-t1x9gknd 6657 29 plasma plasma NN cord-010119-t1x9gknd 6657 30 samples sample NNS cord-010119-t1x9gknd 6657 31 drawn draw VBN cord-010119-t1x9gknd 6657 32 in in IN cord-010119-t1x9gknd 6657 33 the the DT cord-010119-t1x9gknd 6657 34 25th 25th JJ cord-010119-t1x9gknd 6657 35 gestational gestational JJ cord-010119-t1x9gknd 6657 36 week week NN cord-010119-t1x9gknd 6657 37 . . . cord-010119-t1x9gknd 6658 1 Delayed Delayed NNP cord-010119-t1x9gknd 6658 2 Hemolytic Hemolytic NNP cord-010119-t1x9gknd 6658 3 Transfusion Transfusion NNP cord-010119-t1x9gknd 6658 4 Reaction reaction NN cord-010119-t1x9gknd 6659 1 Due due IN cord-010119-t1x9gknd 6659 2 to to IN cord-010119-t1x9gknd 6659 3 Anti Anti NNP cord-010119-t1x9gknd 6659 4 - - NNP cord-010119-t1x9gknd 6659 5 Lan Lan NNP cord-010119-t1x9gknd 6659 6 Antibody Antibody NNP cord-010119-t1x9gknd 6659 7 : : : cord-010119-t1x9gknd 6659 8 A a DT cord-010119-t1x9gknd 6659 9 Case Case NNP cord-010119-t1x9gknd 6659 10 Report Report NNP cord-010119-t1x9gknd 6659 11 . . . cord-010119-t1x9gknd 6660 1 Adla Adla NNP cord-010119-t1x9gknd 6660 2 DH DH NNP cord-010119-t1x9gknd 6660 3 Angelina Angelina NNP cord-010119-t1x9gknd 6661 1 * * NFP cord-010119-t1x9gknd 6661 2 , , , cord-010119-t1x9gknd 6661 3 Suneeti Suneeti NNP cord-010119-t1x9gknd 6661 4 Sapatnekar Sapatnekar NNP cord-010119-t1x9gknd 6661 5 and and CC cord-010119-t1x9gknd 6661 6 Suzanne Suzanne NNP cord-010119-t1x9gknd 6661 7 Bakdash Bakdash NNP cord-010119-t1x9gknd 6661 8 . . . cord-010119-t1x9gknd 6662 1 Cleveland Cleveland NNP cord-010119-t1x9gknd 6662 2 Clinic Clinic NNP cord-010119-t1x9gknd 6662 3 Background Background NNP cord-010119-t1x9gknd 6662 4 / / SYM cord-010119-t1x9gknd 6662 5 Case Case NNP cord-010119-t1x9gknd 6662 6 Studies Studies NNPS cord-010119-t1x9gknd 6663 1 : : : cord-010119-t1x9gknd 6663 2 Lan Lan NNP cord-010119-t1x9gknd 6663 3 is be VBZ cord-010119-t1x9gknd 6663 4 a a DT cord-010119-t1x9gknd 6663 5 high high JJ cord-010119-t1x9gknd 6663 6 - - HYPH cord-010119-t1x9gknd 6663 7 prevalence prevalence NN cord-010119-t1x9gknd 6663 8 antigen antigen NN cord-010119-t1x9gknd 6663 9 and and CC cord-010119-t1x9gknd 6663 10 the the DT cord-010119-t1x9gknd 6663 11 sole sole JJ cord-010119-t1x9gknd 6663 12 member member NN cord-010119-t1x9gknd 6663 13 of of IN cord-010119-t1x9gknd 6663 14 the the DT cord-010119-t1x9gknd 6663 15 LAN LAN NNP cord-010119-t1x9gknd 6663 16 blood blood NN cord-010119-t1x9gknd 6663 17 group group NN cord-010119-t1x9gknd 6663 18 system system NN cord-010119-t1x9gknd 6663 19 . . . cord-010119-t1x9gknd 6664 1 Anti Anti NNP cord-010119-t1x9gknd 6664 2 - - NNP cord-010119-t1x9gknd 6664 3 Lan Lan NNP cord-010119-t1x9gknd 6664 4 is be VBZ cord-010119-t1x9gknd 6664 5 a a DT cord-010119-t1x9gknd 6664 6 very very RB cord-010119-t1x9gknd 6664 7 rare rare JJ cord-010119-t1x9gknd 6664 8 IgG igg NN cord-010119-t1x9gknd 6664 9 antibody antibody NN cord-010119-t1x9gknd 6664 10 , , , cord-010119-t1x9gknd 6664 11 with with IN cord-010119-t1x9gknd 6664 12 conflicting conflict VBG cord-010119-t1x9gknd 6664 13 information information NN cord-010119-t1x9gknd 6664 14 regarding regard VBG cord-010119-t1x9gknd 6664 15 its -PRON- PRP$ cord-010119-t1x9gknd 6664 16 clinical clinical JJ cord-010119-t1x9gknd 6664 17 significance significance NN cord-010119-t1x9gknd 6664 18 and and CC cord-010119-t1x9gknd 6664 19 potential potential NN cord-010119-t1x9gknd 6664 20 for for IN cord-010119-t1x9gknd 6664 21 hemolysis hemolysis NN cord-010119-t1x9gknd 6664 22 . . . cord-010119-t1x9gknd 6665 1 We -PRON- PRP cord-010119-t1x9gknd 6665 2 report report VBP cord-010119-t1x9gknd 6665 3 a a DT cord-010119-t1x9gknd 6665 4 case case NN cord-010119-t1x9gknd 6665 5 of of IN cord-010119-t1x9gknd 6665 6 delayed delayed JJ cord-010119-t1x9gknd 6665 7 hemolysis hemolysis NN cord-010119-t1x9gknd 6665 8 in in IN cord-010119-t1x9gknd 6665 9 a a DT cord-010119-t1x9gknd 6665 10 patient patient NN cord-010119-t1x9gknd 6665 11 with with IN cord-010119-t1x9gknd 6665 12 anti anti JJ cord-010119-t1x9gknd 6665 13 - - JJ cord-010119-t1x9gknd 6665 14 Lan Lan NNP cord-010119-t1x9gknd 6665 15 antibody antibody NN cord-010119-t1x9gknd 6665 16 . . . cord-010119-t1x9gknd 6666 1 Study Study NNP cord-010119-t1x9gknd 6666 2 Design Design NNP cord-010119-t1x9gknd 6666 3 / / SYM cord-010119-t1x9gknd 6666 4 Method method NN cord-010119-t1x9gknd 6666 5 : : : cord-010119-t1x9gknd 6667 1 The the DT cord-010119-t1x9gknd 6667 2 patient patient NN cord-010119-t1x9gknd 6667 3 's 's POS cord-010119-t1x9gknd 6667 4 medical medical JJ cord-010119-t1x9gknd 6667 5 record record NN cord-010119-t1x9gknd 6667 6 and and CC cord-010119-t1x9gknd 6667 7 available available JJ cord-010119-t1x9gknd 6667 8 literature literature NN cord-010119-t1x9gknd 6667 9 were be VBD cord-010119-t1x9gknd 6667 10 reviewed review VBN cord-010119-t1x9gknd 6667 11 . . . cord-010119-t1x9gknd 6668 1 Results/ Results/ . cord-010119-t1x9gknd 6669 1 Finding finding NN cord-010119-t1x9gknd 6669 2 : : : cord-010119-t1x9gknd 6670 1 An an DT cord-010119-t1x9gknd 6670 2 83 83 CD cord-010119-t1x9gknd 6670 3 year year NN cord-010119-t1x9gknd 6670 4 old old JJ cord-010119-t1x9gknd 6670 5 man man NN cord-010119-t1x9gknd 6670 6 , , , cord-010119-t1x9gknd 6670 7 O o NN cord-010119-t1x9gknd 6670 8 - - HYPH cord-010119-t1x9gknd 6670 9 positive positive JJ cord-010119-t1x9gknd 6670 10 , , , cord-010119-t1x9gknd 6670 11 with with IN cord-010119-t1x9gknd 6670 12 a a DT cord-010119-t1x9gknd 6670 13 history history NN cord-010119-t1x9gknd 6670 14 of of IN cord-010119-t1x9gknd 6670 15 heart heart NN cord-010119-t1x9gknd 6670 16 disease disease NN cord-010119-t1x9gknd 6670 17 and and CC cord-010119-t1x9gknd 6670 18 bladder bladder NN cord-010119-t1x9gknd 6670 19 cancer cancer NN cord-010119-t1x9gknd 6670 20 was be VBD cord-010119-t1x9gknd 6670 21 admitted admit VBN cord-010119-t1x9gknd 6670 22 for for IN cord-010119-t1x9gknd 6670 23 radical radical JJ cord-010119-t1x9gknd 6670 24 cystectomy cystectomy NN cord-010119-t1x9gknd 6670 25 . . . cord-010119-t1x9gknd 6671 1 The the DT cord-010119-t1x9gknd 6671 2 antibody antibody NN cord-010119-t1x9gknd 6671 3 screen screen NN cord-010119-t1x9gknd 6671 4 and and CC cord-010119-t1x9gknd 6671 5 panel panel NN cord-010119-t1x9gknd 6671 6 were be VBD cord-010119-t1x9gknd 6671 7 panreactive panreactive JJ cord-010119-t1x9gknd 6671 8 by by IN cord-010119-t1x9gknd 6671 9 multiple multiple JJ cord-010119-t1x9gknd 6671 10 test test NN cord-010119-t1x9gknd 6671 11 methods method NNS cord-010119-t1x9gknd 6671 12 ( ( -LRB- cord-010119-t1x9gknd 6671 13 gel gel NN cord-010119-t1x9gknd 6671 14 , , , cord-010119-t1x9gknd 6671 15 LISS LISS NNP cord-010119-t1x9gknd 6671 16 , , , cord-010119-t1x9gknd 6671 17 PEG PEG NNP cord-010119-t1x9gknd 6671 18 ) ) -RRB- cord-010119-t1x9gknd 6671 19 with with IN cord-010119-t1x9gknd 6671 20 negative negative JJ cord-010119-t1x9gknd 6671 21 autocontrols autocontrol NNS cord-010119-t1x9gknd 6671 22 and and CC cord-010119-t1x9gknd 6671 23 DAT DAT NNP cord-010119-t1x9gknd 6671 24 and and CC cord-010119-t1x9gknd 6671 25 a a DT cord-010119-t1x9gknd 6671 26 saline saline NN cord-010119-t1x9gknd 6671 27 antibody antibody NN cord-010119-t1x9gknd 6671 28 titer titer NN cord-010119-t1x9gknd 6671 29 of of IN cord-010119-t1x9gknd 6671 30 1 1 CD cord-010119-t1x9gknd 6671 31 , , , cord-010119-t1x9gknd 6671 32 suggestive suggestive JJ cord-010119-t1x9gknd 6671 33 of of IN cord-010119-t1x9gknd 6671 34 an an DT cord-010119-t1x9gknd 6671 35 antibody antibody NN cord-010119-t1x9gknd 6671 36 to to IN cord-010119-t1x9gknd 6671 37 a a DT cord-010119-t1x9gknd 6671 38 high high JJ cord-010119-t1x9gknd 6671 39 - - HYPH cord-010119-t1x9gknd 6671 40 frequency frequency NN cord-010119-t1x9gknd 6671 41 antigen antigen NN cord-010119-t1x9gknd 6671 42 . . . cord-010119-t1x9gknd 6672 1 Anti Anti NNP cord-010119-t1x9gknd 6672 2 - - NNP cord-010119-t1x9gknd 6672 3 Lan Lan NNP cord-010119-t1x9gknd 6672 4 antibody antibody NN cord-010119-t1x9gknd 6672 5 was be VBD cord-010119-t1x9gknd 6672 6 identified identify VBN cord-010119-t1x9gknd 6672 7 by by IN cord-010119-t1x9gknd 6672 8 a a DT cord-010119-t1x9gknd 6672 9 reference reference NN cord-010119-t1x9gknd 6672 10 laboratory laboratory NN cord-010119-t1x9gknd 6672 11 . . . cord-010119-t1x9gknd 6673 1 Only only RB cord-010119-t1x9gknd 6673 2 1 1 CD cord-010119-t1x9gknd 6673 3 in in IN cord-010119-t1x9gknd 6673 4 20,000 20,000 CD cord-010119-t1x9gknd 6673 5 donors donor NNS cord-010119-t1x9gknd 6673 6 are be VBP cord-010119-t1x9gknd 6673 7 Lan- Lan- NNP cord-010119-t1x9gknd 6673 8 , , , cord-010119-t1x9gknd 6673 9 but but CC cord-010119-t1x9gknd 6673 10 two two CD cord-010119-t1x9gknd 6673 11 frozen frozen JJ cord-010119-t1x9gknd 6673 12 RBC RBC NNP cord-010119-t1x9gknd 6673 13 units unit NNS cord-010119-t1x9gknd 6673 14 were be VBD cord-010119-t1x9gknd 6673 15 locally locally RB cord-010119-t1x9gknd 6673 16 available available JJ cord-010119-t1x9gknd 6673 17 and and CC cord-010119-t1x9gknd 6673 18 transfused transfuse VBN cord-010119-t1x9gknd 6673 19 postoperatively postoperatively RB cord-010119-t1x9gknd 6673 20 . . . cord-010119-t1x9gknd 6674 1 The the DT cord-010119-t1x9gknd 6674 2 patient patient NN cord-010119-t1x9gknd 6674 3 's 's POS cord-010119-t1x9gknd 6674 4 siblings sibling NNS cord-010119-t1x9gknd 6674 5 were be VBD cord-010119-t1x9gknd 6674 6 tested test VBN cord-010119-t1x9gknd 6674 7 ; ; : cord-010119-t1x9gknd 6674 8 one one CD cord-010119-t1x9gknd 6674 9 O o NN cord-010119-t1x9gknd 6674 10 - - HYPH cord-010119-t1x9gknd 6674 11 positive positive JJ cord-010119-t1x9gknd 6674 12 , , , cord-010119-t1x9gknd 6674 13 Lan Lan NNP cord-010119-t1x9gknd 6674 14 - - HYPH cord-010119-t1x9gknd 6674 15 sibling sibling NN cord-010119-t1x9gknd 6674 16 was be VBD cord-010119-t1x9gknd 6674 17 identified identify VBN cord-010119-t1x9gknd 6674 18 . . . cord-010119-t1x9gknd 6675 1 Nine nine CD cord-010119-t1x9gknd 6675 2 months month NNS cord-010119-t1x9gknd 6675 3 later later RB cord-010119-t1x9gknd 6675 4 , , , cord-010119-t1x9gknd 6675 5 the the DT cord-010119-t1x9gknd 6675 6 patient patient NN cord-010119-t1x9gknd 6675 7 was be VBD cord-010119-t1x9gknd 6675 8 admitted admit VBN cord-010119-t1x9gknd 6675 9 for for IN cord-010119-t1x9gknd 6675 10 surgical surgical JJ cord-010119-t1x9gknd 6675 11 management management NN cord-010119-t1x9gknd 6675 12 of of IN cord-010119-t1x9gknd 6675 13 metastases metastasis NNS cord-010119-t1x9gknd 6675 14 . . . cord-010119-t1x9gknd 6676 1 At at IN cord-010119-t1x9gknd 6676 2 this this DT cord-010119-t1x9gknd 6676 3 time time NN cord-010119-t1x9gknd 6676 4 , , , cord-010119-t1x9gknd 6676 5 the the DT cord-010119-t1x9gknd 6676 6 antibody antibody NN cord-010119-t1x9gknd 6676 7 screen screen NN cord-010119-t1x9gknd 6676 8 was be VBD cord-010119-t1x9gknd 6676 9 weakly weakly RB cord-010119-t1x9gknd 6676 10 reactive reactive JJ cord-010119-t1x9gknd 6676 11 with with IN cord-010119-t1x9gknd 6676 12 1 1 CD cord-010119-t1x9gknd 6676 13 cell cell NN cord-010119-t1x9gknd 6676 14 and and CC cord-010119-t1x9gknd 6676 15 new new JJ cord-010119-t1x9gknd 6676 16 antibodies antibody NNS cord-010119-t1x9gknd 6676 17 were be VBD cord-010119-t1x9gknd 6676 18 ruled rule VBN cord-010119-t1x9gknd 6676 19 out out RP cord-010119-t1x9gknd 6676 20 . . . cord-010119-t1x9gknd 6677 1 Blood blood NN cord-010119-t1x9gknd 6677 2 conservation conservation NN cord-010119-t1x9gknd 6677 3 measures measure NNS cord-010119-t1x9gknd 6677 4 were be VBD cord-010119-t1x9gknd 6677 5 instituted institute VBN cord-010119-t1x9gknd 6677 6 , , , cord-010119-t1x9gknd 6677 7 including include VBG cord-010119-t1x9gknd 6677 8 limited limited JJ cord-010119-t1x9gknd 6677 9 blood blood NN cord-010119-t1x9gknd 6677 10 draws draw NNS cord-010119-t1x9gknd 6677 11 and and CC cord-010119-t1x9gknd 6677 12 cell cell NN cord-010119-t1x9gknd 6677 13 salvage salvage NN cord-010119-t1x9gknd 6677 14 for for IN cord-010119-t1x9gknd 6677 15 surgery surgery NN cord-010119-t1x9gknd 6677 16 . . . cord-010119-t1x9gknd 6678 1 Due due IN cord-010119-t1x9gknd 6678 2 to to IN cord-010119-t1x9gknd 6678 3 bleeding bleed VBG cord-010119-t1x9gknd 6678 4 during during IN cord-010119-t1x9gknd 6678 5 and and CC cord-010119-t1x9gknd 6678 6 after after IN cord-010119-t1x9gknd 6678 7 surgery surgery NN cord-010119-t1x9gknd 6678 8 , , , cord-010119-t1x9gknd 6678 9 4 4 CD cord-010119-t1x9gknd 6678 10 Lan Lan NNP cord-010119-t1x9gknd 6678 11 - - HYPH cord-010119-t1x9gknd 6678 12 RBC RBC NNP cord-010119-t1x9gknd 6678 13 units unit NNS cord-010119-t1x9gknd 6678 14 were be VBD cord-010119-t1x9gknd 6678 15 transfused transfuse VBN cord-010119-t1x9gknd 6678 16 over over IN cord-010119-t1x9gknd 6678 17 4 4 CD cord-010119-t1x9gknd 6678 18 days day NNS cord-010119-t1x9gknd 6678 19 , , , cord-010119-t1x9gknd 6678 20 including include VBG cord-010119-t1x9gknd 6678 21 rare rare JJ cord-010119-t1x9gknd 6678 22 donor donor NN cord-010119-t1x9gknd 6678 23 units unit NNS cord-010119-t1x9gknd 6678 24 and and CC cord-010119-t1x9gknd 6678 25 units unit NNS cord-010119-t1x9gknd 6678 26 from from IN cord-010119-t1x9gknd 6678 27 the the DT cord-010119-t1x9gknd 6678 28 sibling sibling NN cord-010119-t1x9gknd 6678 29 donor donor NN cord-010119-t1x9gknd 6678 30 . . . cord-010119-t1x9gknd 6679 1 Another another DT cord-010119-t1x9gknd 6679 2 surgical surgical JJ cord-010119-t1x9gknd 6679 3 procedure procedure NN cord-010119-t1x9gknd 6679 4 was be VBD cord-010119-t1x9gknd 6679 5 then then RB cord-010119-t1x9gknd 6679 6 performed perform VBN cord-010119-t1x9gknd 6679 7 ; ; : cord-010119-t1x9gknd 6679 8 by by IN cord-010119-t1x9gknd 6679 9 post post JJ cord-010119-t1x9gknd 6679 10 - - JJ cord-010119-t1x9gknd 6679 11 operative operative JJ cord-010119-t1x9gknd 6679 12 day day NN cord-010119-t1x9gknd 6679 13 2 2 CD cord-010119-t1x9gknd 6679 14 , , , cord-010119-t1x9gknd 6679 15 the the DT cord-010119-t1x9gknd 6679 16 patient patient NN cord-010119-t1x9gknd 6679 17 had have VBD cord-010119-t1x9gknd 6679 18 symptomatic symptomatic JJ cord-010119-t1x9gknd 6679 19 anemia anemia NN cord-010119-t1x9gknd 6679 20 with with IN cord-010119-t1x9gknd 6679 21 hemoglobin hemoglobin NN cord-010119-t1x9gknd 6679 22 ( ( -LRB- cord-010119-t1x9gknd 6679 23 Hb Hb NNP cord-010119-t1x9gknd 6679 24 ) ) -RRB- cord-010119-t1x9gknd 6679 25 5.3 5.3 CD cord-010119-t1x9gknd 6679 26 g g NN cord-010119-t1x9gknd 6679 27 / / SYM cord-010119-t1x9gknd 6679 28 dL dl NN cord-010119-t1x9gknd 6679 29 and and CC cord-010119-t1x9gknd 6679 30 serially serially RB cord-010119-t1x9gknd 6679 31 increasing increase VBG cord-010119-t1x9gknd 6679 32 troponin troponin JJ cord-010119-t1x9gknd 6679 33 . . . cord-010119-t1x9gknd 6680 1 No no DT cord-010119-t1x9gknd 6680 2 Lan Lan NNP cord-010119-t1x9gknd 6680 3 - - HYPH cord-010119-t1x9gknd 6680 4 RBC RBC NNP cord-010119-t1x9gknd 6680 5 units unit NNS cord-010119-t1x9gknd 6680 6 were be VBD cord-010119-t1x9gknd 6680 7 available available JJ cord-010119-t1x9gknd 6680 8 . . . cord-010119-t1x9gknd 6681 1 Four four CD cord-010119-t1x9gknd 6681 2 RBC RBC NNP cord-010119-t1x9gknd 6681 3 units unit NNS cord-010119-t1x9gknd 6681 4 untested untested JJ cord-010119-t1x9gknd 6681 5 for for IN cord-010119-t1x9gknd 6681 6 Lan Lan NNP cord-010119-t1x9gknd 6681 7 were be VBD cord-010119-t1x9gknd 6681 8 transfused transfuse VBN cord-010119-t1x9gknd 6681 9 without without IN cord-010119-t1x9gknd 6681 10 adverse adverse JJ cord-010119-t1x9gknd 6681 11 event event NN cord-010119-t1x9gknd 6681 12 ; ; : cord-010119-t1x9gknd 6681 13 the the DT cord-010119-t1x9gknd 6681 14 units unit NNS cord-010119-t1x9gknd 6681 15 were be VBD cord-010119-t1x9gknd 6681 16 presumed presume VBN cord-010119-t1x9gknd 6681 17 Lan1 Lan1 NNP cord-010119-t1x9gknd 6681 18 but but CC cord-010119-t1x9gknd 6681 19 crossmatch crossmatch NN cord-010119-t1x9gknd 6681 20 compatible compatible JJ cord-010119-t1x9gknd 6681 21 and and CC cord-010119-t1x9gknd 6681 22 phenotypically phenotypically RB cord-010119-t1x9gknd 6681 23 matched match VBN cord-010119-t1x9gknd 6681 24 for for IN cord-010119-t1x9gknd 6681 25 the the DT cord-010119-t1x9gknd 6681 26 patient patient NN cord-010119-t1x9gknd 6681 27 's 's POS cord-010119-t1x9gknd 6681 28 other other JJ cord-010119-t1x9gknd 6681 29 antigens antigen NNS cord-010119-t1x9gknd 6681 30 . . . cord-010119-t1x9gknd 6682 1 A a DT cord-010119-t1x9gknd 6682 2 post post JJ cord-010119-t1x9gknd 6682 3 - - JJ cord-010119-t1x9gknd 6682 4 transfusion transfusion NN cord-010119-t1x9gknd 6682 5 Hb Hb NNP cord-010119-t1x9gknd 6682 6 of of IN cord-010119-t1x9gknd 6682 7 10.2 10.2 CD cord-010119-t1x9gknd 6682 8 g g NNP cord-010119-t1x9gknd 6682 9 / / SYM cord-010119-t1x9gknd 6682 10 dL dL NNP cord-010119-t1x9gknd 6682 11 was be VBD cord-010119-t1x9gknd 6682 12 maintained maintain VBN cord-010119-t1x9gknd 6682 13 for for IN cord-010119-t1x9gknd 6682 14 4 4 CD cord-010119-t1x9gknd 6682 15 days day NNS cord-010119-t1x9gknd 6682 16 . . . cord-010119-t1x9gknd 6683 1 The the DT cord-010119-t1x9gknd 6683 2 antibody antibody NN cord-010119-t1x9gknd 6683 3 screen screen NN cord-010119-t1x9gknd 6683 4 was be VBD cord-010119-t1x9gknd 6683 5 negative negative JJ cord-010119-t1x9gknd 6683 6 on on IN cord-010119-t1x9gknd 6683 7 day day NN cord-010119-t1x9gknd 6683 8 3 3 CD cord-010119-t1x9gknd 6683 9 post post JJ cord-010119-t1x9gknd 6683 10 - - JJ cord-010119-t1x9gknd 6683 11 transfusion transfusion NN cord-010119-t1x9gknd 6683 12 , , , cord-010119-t1x9gknd 6683 13 but but CC cord-010119-t1x9gknd 6683 14 strongly strongly RB cord-010119-t1x9gknd 6683 15 panreactive panreactive JJ cord-010119-t1x9gknd 6683 16 on on IN cord-010119-t1x9gknd 6683 17 day day NN cord-010119-t1x9gknd 6683 18 6 6 CD cord-010119-t1x9gknd 6683 19 , , , cord-010119-t1x9gknd 6683 20 with with IN cord-010119-t1x9gknd 6683 21 a a DT cord-010119-t1x9gknd 6683 22 positive positive JJ cord-010119-t1x9gknd 6683 23 DAT DAT NNP cord-010119-t1x9gknd 6683 24 ( ( -LRB- cord-010119-t1x9gknd 6683 25 IgG IgG NNP cord-010119-t1x9gknd 6683 26 21 21 CD cord-010119-t1x9gknd 6683 27 , , , cord-010119-t1x9gknd 6683 28 C3 C3 NNP cord-010119-t1x9gknd 6683 29 11 11 CD cord-010119-t1x9gknd 6683 30 ) ) -RRB- cord-010119-t1x9gknd 6683 31 and and CC cord-010119-t1x9gknd 6683 32 anti anti JJ cord-010119-t1x9gknd 6683 33 - - JJ cord-010119-t1x9gknd 6683 34 Lan Lan NNP cord-010119-t1x9gknd 6683 35 antibody antibody NN cord-010119-t1x9gknd 6683 36 identified identify VBN cord-010119-t1x9gknd 6683 37 in in IN cord-010119-t1x9gknd 6683 38 the the DT cord-010119-t1x9gknd 6683 39 plasma plasma NN cord-010119-t1x9gknd 6683 40 and and CC cord-010119-t1x9gknd 6683 41 eluate eluate NN cord-010119-t1x9gknd 6683 42 . . . cord-010119-t1x9gknd 6684 1 There there EX cord-010119-t1x9gknd 6684 2 was be VBD cord-010119-t1x9gknd 6684 3 also also RB cord-010119-t1x9gknd 6684 4 evidence evidence NN cord-010119-t1x9gknd 6684 5 of of IN cord-010119-t1x9gknd 6684 6 extra extra JJ cord-010119-t1x9gknd 6684 7 - - JJ cord-010119-t1x9gknd 6684 8 vascular vascular JJ cord-010119-t1x9gknd 6684 9 hemolysis hemolysis NN cord-010119-t1x9gknd 6684 10 , , , cord-010119-t1x9gknd 6684 11 including include VBG cord-010119-t1x9gknd 6684 12 a a DT cord-010119-t1x9gknd 6684 13 progressive progressive JJ cord-010119-t1x9gknd 6684 14 decrease decrease NN cord-010119-t1x9gknd 6684 15 in in IN cord-010119-t1x9gknd 6684 16 Hb Hb NNP cord-010119-t1x9gknd 6684 17 from from IN cord-010119-t1x9gknd 6684 18 10.9 10.9 CD cord-010119-t1x9gknd 6684 19 g g NN cord-010119-t1x9gknd 6684 20 / / SYM cord-010119-t1x9gknd 6684 21 dL dl NN cord-010119-t1x9gknd 6684 22 on on IN cord-010119-t1x9gknd 6684 23 day day NN cord-010119-t1x9gknd 6685 1 5 5 CD cord-010119-t1x9gknd 6685 2 to to IN cord-010119-t1x9gknd 6685 3 7.4 7.4 CD cord-010119-t1x9gknd 6685 4 g g NN cord-010119-t1x9gknd 6685 5 / / SYM cord-010119-t1x9gknd 6685 6 dL dl NN cord-010119-t1x9gknd 6685 7 by by IN cord-010119-t1x9gknd 6685 8 day day NN cord-010119-t1x9gknd 6685 9 8 8 CD cord-010119-t1x9gknd 6685 10 with with IN cord-010119-t1x9gknd 6685 11 no no DT cord-010119-t1x9gknd 6685 12 bleeding bleeding NN cord-010119-t1x9gknd 6685 13 identified identify VBN cord-010119-t1x9gknd 6685 14 , , , cord-010119-t1x9gknd 6685 15 and and CC cord-010119-t1x9gknd 6685 16 increase increase VB cord-010119-t1x9gknd 6685 17 in in IN cord-010119-t1x9gknd 6685 18 total total JJ cord-010119-t1x9gknd 6685 19 bilirubin bilirubin NN cord-010119-t1x9gknd 6685 20 and and CC cord-010119-t1x9gknd 6685 21 LDH LDH NNP cord-010119-t1x9gknd 6685 22 ( ( -LRB- cord-010119-t1x9gknd 6685 23 peak peak NNP cord-010119-t1x9gknd 6685 24 2.4 2.4 CD cord-010119-t1x9gknd 6685 25 mg mg NNP cord-010119-t1x9gknd 6685 26 / / SYM cord-010119-t1x9gknd 6685 27 dL dl NN cord-010119-t1x9gknd 6685 28 and and CC cord-010119-t1x9gknd 6685 29 304 304 CD cord-010119-t1x9gknd 6685 30 U U NNP cord-010119-t1x9gknd 6685 31 / / SYM cord-010119-t1x9gknd 6685 32 L l NN cord-010119-t1x9gknd 6685 33 on on IN cord-010119-t1x9gknd 6685 34 day day NN cord-010119-t1x9gknd 6685 35 7 7 CD cord-010119-t1x9gknd 6685 36 ) ) -RRB- cord-010119-t1x9gknd 6685 37 with with IN cord-010119-t1x9gknd 6685 38 normal normal JJ cord-010119-t1x9gknd 6685 39 haptoglobin haptoglobin NN cord-010119-t1x9gknd 6685 40 . . . cord-010119-t1x9gknd 6686 1 The the DT cord-010119-t1x9gknd 6686 2 patient patient NN cord-010119-t1x9gknd 6686 3 was be VBD cord-010119-t1x9gknd 6686 4 febrile febrile JJ cord-010119-t1x9gknd 6686 5 with with IN cord-010119-t1x9gknd 6686 6 leukocytosis leukocytosis NN cord-010119-t1x9gknd 6686 7 , , , cord-010119-t1x9gknd 6686 8 but but CC cord-010119-t1x9gknd 6686 9 had have VBD cord-010119-t1x9gknd 6686 10 negative negative JJ cord-010119-t1x9gknd 6686 11 cultures culture NNS cord-010119-t1x9gknd 6686 12 and and CC cord-010119-t1x9gknd 6686 13 no no DT cord-010119-t1x9gknd 6686 14 other other JJ cord-010119-t1x9gknd 6686 15 evidence evidence NN cord-010119-t1x9gknd 6686 16 of of IN cord-010119-t1x9gknd 6686 17 infection infection NN cord-010119-t1x9gknd 6686 18 . . . cord-010119-t1x9gknd 6687 1 A a DT cord-010119-t1x9gknd 6687 2 Lan Lan NNP cord-010119-t1x9gknd 6687 3 - - HYPH cord-010119-t1x9gknd 6687 4 RBC RBC NNP cord-010119-t1x9gknd 6687 5 unit unit NN cord-010119-t1x9gknd 6687 6 was be VBD cord-010119-t1x9gknd 6687 7 transfused transfuse VBN cord-010119-t1x9gknd 6687 8 on on IN cord-010119-t1x9gknd 6687 9 day day NN cord-010119-t1x9gknd 6687 10 8 8 CD cord-010119-t1x9gknd 6687 11 with with IN cord-010119-t1x9gknd 6687 12 good good JJ cord-010119-t1x9gknd 6687 13 response response NN cord-010119-t1x9gknd 6687 14 ( ( -LRB- cord-010119-t1x9gknd 6687 15 Hb Hb NNP cord-010119-t1x9gknd 6687 16 8.1 8.1 CD cord-010119-t1x9gknd 6687 17 g g NN cord-010119-t1x9gknd 6687 18 / / SYM cord-010119-t1x9gknd 6687 19 dL dl NN cord-010119-t1x9gknd 6687 20 ) ) -RRB- cord-010119-t1x9gknd 6687 21 . . . cord-010119-t1x9gknd 6688 1 The the DT cord-010119-t1x9gknd 6688 2 patient patient NN cord-010119-t1x9gknd 6688 3 remained remain VBD cord-010119-t1x9gknd 6688 4 stable stable JJ cord-010119-t1x9gknd 6688 5 and and CC cord-010119-t1x9gknd 6688 6 was be VBD cord-010119-t1x9gknd 6688 7 discharged discharge VBN cord-010119-t1x9gknd 6688 8 to to IN cord-010119-t1x9gknd 6688 9 a a DT cord-010119-t1x9gknd 6688 10 skilled skilled JJ cord-010119-t1x9gknd 6688 11 nursing nursing NN cord-010119-t1x9gknd 6688 12 facility facility NN cord-010119-t1x9gknd 6688 13 6 6 CD cord-010119-t1x9gknd 6688 14 days day NNS cord-010119-t1x9gknd 6688 15 later later RB cord-010119-t1x9gknd 6688 16 . . . cord-010119-t1x9gknd 6689 1 Conclusion conclusion NN cord-010119-t1x9gknd 6689 2 : : : cord-010119-t1x9gknd 6690 1 Transfusion transfusion NN cord-010119-t1x9gknd 6690 2 of of IN cord-010119-t1x9gknd 6690 3 Lan1 Lan1 NNP cord-010119-t1x9gknd 6690 4 RBCs rbc NNS cord-010119-t1x9gknd 6690 5 caused cause VBD cord-010119-t1x9gknd 6690 6 a a DT cord-010119-t1x9gknd 6690 7 resurgence resurgence NN cord-010119-t1x9gknd 6690 8 of of IN cord-010119-t1x9gknd 6690 9 anti anti JJ cord-010119-t1x9gknd 6690 10 - - JJ cord-010119-t1x9gknd 6690 11 Lan Lan NNP cord-010119-t1x9gknd 6690 12 antibody antibody NN cord-010119-t1x9gknd 6690 13 and and CC cord-010119-t1x9gknd 6690 14 a a DT cord-010119-t1x9gknd 6690 15 delayed delay VBN cord-010119-t1x9gknd 6690 16 hemolytic hemolytic JJ cord-010119-t1x9gknd 6690 17 transfusion transfusion NN cord-010119-t1x9gknd 6690 18 reaction reaction NN cord-010119-t1x9gknd 6690 19 6 6 CD cord-010119-t1x9gknd 6690 20 days day NNS cord-010119-t1x9gknd 6690 21 after after IN cord-010119-t1x9gknd 6690 22 transfusion transfusion NN cord-010119-t1x9gknd 6690 23 . . . cord-010119-t1x9gknd 6691 1 The the DT cord-010119-t1x9gknd 6691 2 rarity rarity NN cord-010119-t1x9gknd 6691 3 of of IN cord-010119-t1x9gknd 6691 4 Lan Lan NNP cord-010119-t1x9gknd 6691 5 - - HYPH cord-010119-t1x9gknd 6691 6 units unit NNS cord-010119-t1x9gknd 6691 7 may may MD cord-010119-t1x9gknd 6691 8 require require VB cord-010119-t1x9gknd 6691 9 a a DT cord-010119-t1x9gknd 6691 10 patient patient NN cord-010119-t1x9gknd 6691 11 with with IN cord-010119-t1x9gknd 6691 12 anti anti JJ cord-010119-t1x9gknd 6691 13 - - NNP cord-010119-t1x9gknd 6691 14 Lan Lan NNP cord-010119-t1x9gknd 6691 15 to to TO cord-010119-t1x9gknd 6691 16 be be VB cord-010119-t1x9gknd 6691 17 transfused transfuse VBN cord-010119-t1x9gknd 6691 18 with with IN cord-010119-t1x9gknd 6691 19 Lan1 Lan1 NNP cord-010119-t1x9gknd 6691 20 units unit NNS cord-010119-t1x9gknd 6691 21 , , , cord-010119-t1x9gknd 6691 22 but but CC cord-010119-t1x9gknd 6691 23 close close JJ cord-010119-t1x9gknd 6691 24 monitoring monitoring NN cord-010119-t1x9gknd 6691 25 for for IN cord-010119-t1x9gknd 6691 26 delayed delayed JJ cord-010119-t1x9gknd 6691 27 hemolysis hemolysis NN cord-010119-t1x9gknd 6691 28 is be VBZ cord-010119-t1x9gknd 6691 29 necessary necessary JJ cord-010119-t1x9gknd 6691 30 even even RB cord-010119-t1x9gknd 6691 31 if if IN cord-010119-t1x9gknd 6691 32 the the DT cord-010119-t1x9gknd 6691 33 antibody antibody NN cord-010119-t1x9gknd 6691 34 is be VBZ cord-010119-t1x9gknd 6691 35 not not RB cord-010119-t1x9gknd 6691 36 demonstrable demonstrable JJ cord-010119-t1x9gknd 6691 37 at at IN cord-010119-t1x9gknd 6691 38 the the DT cord-010119-t1x9gknd 6691 39 time time NN cord-010119-t1x9gknd 6691 40 of of IN cord-010119-t1x9gknd 6691 41 transfusion transfusion NN cord-010119-t1x9gknd 6691 42 . . . cord-010119-t1x9gknd 6692 1 Delayed delay VBN cord-010119-t1x9gknd 6692 2 Serologic Serologic NNP cord-010119-t1x9gknd 6692 3 Transfusion Transfusion NNP cord-010119-t1x9gknd 6692 4 Reaction reaction NN cord-010119-t1x9gknd 6692 5 Caused cause VBN cord-010119-t1x9gknd 6692 6 By by IN cord-010119-t1x9gknd 6692 7 Auto Auto NNP cord-010119-t1x9gknd 6692 8 - - HYPH cord-010119-t1x9gknd 6692 9 Anti Anti NNP cord-010119-t1x9gknd 6692 10 - - HYPH cord-010119-t1x9gknd 6692 11 f f NNP cord-010119-t1x9gknd 6692 12 . . . cord-010119-t1x9gknd 6693 1 Karen Karen NNP cord-010119-t1x9gknd 6693 2 Yunker Yunker NNP cord-010119-t1x9gknd 6693 3 * * NFP cord-010119-t1x9gknd 6693 4 1 1 CD cord-010119-t1x9gknd 6693 5 , , , cord-010119-t1x9gknd 6693 6 Andrea Andrea NNP cord-010119-t1x9gknd 6693 7 Gerner Gerner NNP cord-010119-t1x9gknd 6693 8 1 1 CD cord-010119-t1x9gknd 6693 9 , , , cord-010119-t1x9gknd 6693 10 Lynne Lynne NNP cord-010119-t1x9gknd 6693 11 Stewart Stewart NNP cord-010119-t1x9gknd 6693 12 1 1 CD cord-010119-t1x9gknd 6693 13 , , , cord-010119-t1x9gknd 6693 14 Carol Carol NNP cord-010119-t1x9gknd 6693 15 Sostok Sostok NNP cord-010119-t1x9gknd 6693 16 1 1 CD cord-010119-t1x9gknd 6693 17 , , , cord-010119-t1x9gknd 6693 18 Mollie Mollie NNP cord-010119-t1x9gknd 6693 19 Bell Bell NNP cord-010119-t1x9gknd 6693 20 2 2 CD cord-010119-t1x9gknd 6693 21 and and CC cord-010119-t1x9gknd 6693 22 Gregory Gregory NNP cord-010119-t1x9gknd 6693 23 R R NNP cord-010119-t1x9gknd 6693 24 Halverson Halverson NNP cord-010119-t1x9gknd 6693 25 2 2 CD cord-010119-t1x9gknd 6693 26 . . . cord-010119-t1x9gknd 6693 27 1 1 CD cord-010119-t1x9gknd 6694 1 St. St. NNP cord-010119-t1x9gknd 6694 2 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 6694 3 Healthcare Healthcare NNP cord-010119-t1x9gknd 6694 4 , , , cord-010119-t1x9gknd 6694 5 2 2 CD cord-010119-t1x9gknd 6694 6 Hoxworth Hoxworth NNP cord-010119-t1x9gknd 6694 7 Blood Blood NNP cord-010119-t1x9gknd 6694 8 Center Center NNP cord-010119-t1x9gknd 6694 9 Background Background NNP cord-010119-t1x9gknd 6694 10 / / SYM cord-010119-t1x9gknd 6694 11 Case Case NNP cord-010119-t1x9gknd 6694 12 Studies Studies NNPS cord-010119-t1x9gknd 6694 13 : : : cord-010119-t1x9gknd 6694 14 Anti Anti NNP cord-010119-t1x9gknd 6694 15 - - NNP cord-010119-t1x9gknd 6694 16 f f NNP cord-010119-t1x9gknd 6694 17 was be VBD cord-010119-t1x9gknd 6694 18 first first RB cord-010119-t1x9gknd 6694 19 described describe VBN cord-010119-t1x9gknd 6694 20 in in IN cord-010119-t1x9gknd 6694 21 1953 1953 CD cord-010119-t1x9gknd 6694 22 by by IN cord-010119-t1x9gknd 6694 23 Rosenfield Rosenfield NNP cord-010119-t1x9gknd 6694 24 and and CC cord-010119-t1x9gknd 6694 25 coworkers coworker NNS cord-010119-t1x9gknd 6694 26 in in IN cord-010119-t1x9gknd 6694 27 the the DT cord-010119-t1x9gknd 6694 28 serum serum NN cord-010119-t1x9gknd 6694 29 of of IN cord-010119-t1x9gknd 6694 30 a a DT cord-010119-t1x9gknd 6694 31 hemophiliac hemophiliac NN cord-010119-t1x9gknd 6694 32 who who WP cord-010119-t1x9gknd 6694 33 had have VBD cord-010119-t1x9gknd 6694 34 been be VBN cord-010119-t1x9gknd 6694 35 multiply multiply VB cord-010119-t1x9gknd 6694 36 transfused transfuse VBN cord-010119-t1x9gknd 6694 37 . . . cord-010119-t1x9gknd 6695 1 The the DT cord-010119-t1x9gknd 6695 2 f f NNP cord-010119-t1x9gknd 6695 3 antigen antigen NN cord-010119-t1x9gknd 6695 4 is be VBZ cord-010119-t1x9gknd 6695 5 comprised comprise VBN cord-010119-t1x9gknd 6695 6 of of IN cord-010119-t1x9gknd 6695 7 the the DT cord-010119-t1x9gknd 6695 8 c c NN cord-010119-t1x9gknd 6695 9 and and CC cord-010119-t1x9gknd 6695 10 e e NN cord-010119-t1x9gknd 6695 11 antigens antigen NNS cord-010119-t1x9gknd 6695 12 alligned alligne VBN cord-010119-t1x9gknd 6695 13 in in IN cord-010119-t1x9gknd 6695 14 cis cis NNP cord-010119-t1x9gknd 6695 15 on on IN cord-010119-t1x9gknd 6695 16 the the DT cord-010119-t1x9gknd 6695 17 same same JJ cord-010119-t1x9gknd 6695 18 chromosome chromosome NN cord-010119-t1x9gknd 6695 19 , , , cord-010119-t1x9gknd 6695 20 and and CC cord-010119-t1x9gknd 6695 21 is be VBZ cord-010119-t1x9gknd 6695 22 the the DT cord-010119-t1x9gknd 6695 23 6th 6th JJ cord-010119-t1x9gknd 6695 24 antigen antigen NN cord-010119-t1x9gknd 6695 25 assigned assign VBN cord-010119-t1x9gknd 6695 26 to to IN cord-010119-t1x9gknd 6695 27 the the DT cord-010119-t1x9gknd 6695 28 Rh Rh NNP cord-010119-t1x9gknd 6695 29 Blood Blood NNP cord-010119-t1x9gknd 6695 30 Group Group NNP cord-010119-t1x9gknd 6695 31 System System NNP cord-010119-t1x9gknd 6695 32 ( ( -LRB- cord-010119-t1x9gknd 6695 33 ISBT ISBT NNP cord-010119-t1x9gknd 6695 34 RH6 RH6 NNP cord-010119-t1x9gknd 6695 35 ) ) -RRB- cord-010119-t1x9gknd 6695 36 . . . cord-010119-t1x9gknd 6696 1 It -PRON- PRP cord-010119-t1x9gknd 6696 2 is be VBZ cord-010119-t1x9gknd 6696 3 capable capable JJ cord-010119-t1x9gknd 6696 4 of of IN cord-010119-t1x9gknd 6696 5 causing cause VBG cord-010119-t1x9gknd 6696 6 significant significant JJ cord-010119-t1x9gknd 6696 7 transfusion transfusion NN cord-010119-t1x9gknd 6696 8 reactions reaction NNS cord-010119-t1x9gknd 6696 9 and and CC cord-010119-t1x9gknd 6696 10 mild mild JJ cord-010119-t1x9gknd 6696 11 HDFN HDFN NNP cord-010119-t1x9gknd 6696 12 . . . cord-010119-t1x9gknd 6697 1 We -PRON- PRP cord-010119-t1x9gknd 6697 2 report report VBP cord-010119-t1x9gknd 6697 3 in in IN cord-010119-t1x9gknd 6697 4 this this DT cord-010119-t1x9gknd 6697 5 case case NN cord-010119-t1x9gknd 6697 6 a a DT cord-010119-t1x9gknd 6697 7 56 56 CD cord-010119-t1x9gknd 6697 8 year year NN cord-010119-t1x9gknd 6697 9 old old JJ cord-010119-t1x9gknd 6697 10 caucasian caucasian JJ cord-010119-t1x9gknd 6697 11 male male NN cord-010119-t1x9gknd 6697 12 , , , cord-010119-t1x9gknd 6697 13 admitted admit VBN cord-010119-t1x9gknd 6697 14 for for IN cord-010119-t1x9gknd 6697 15 evaluation evaluation NN cord-010119-t1x9gknd 6697 16 of of IN cord-010119-t1x9gknd 6697 17 suspected suspect VBN cord-010119-t1x9gknd 6697 18 T t NN cord-010119-t1x9gknd 6697 19 - - HYPH cord-010119-t1x9gknd 6697 20 cell cell NN cord-010119-t1x9gknd 6697 21 lymphoma lymphoma NN cord-010119-t1x9gknd 6697 22 , , , cord-010119-t1x9gknd 6697 23 who who WP cord-010119-t1x9gknd 6697 24 appears appear VBZ cord-010119-t1x9gknd 6697 25 to to TO cord-010119-t1x9gknd 6697 26 have have VB cord-010119-t1x9gknd 6697 27 had have VBN cord-010119-t1x9gknd 6697 28 a a DT cord-010119-t1x9gknd 6697 29 Delayed delay VBN cord-010119-t1x9gknd 6697 30 Serologic Serologic NNP cord-010119-t1x9gknd 6697 31 Transfusion Transfusion NNP cord-010119-t1x9gknd 6697 32 Reaction reaction NN cord-010119-t1x9gknd 6697 33 ( ( -LRB- cord-010119-t1x9gknd 6697 34 DSTR DSTR NNP cord-010119-t1x9gknd 6697 35 ) ) -RRB- cord-010119-t1x9gknd 6697 36 due due IN cord-010119-t1x9gknd 6697 37 to to IN cord-010119-t1x9gknd 6697 38 auto auto NN cord-010119-t1x9gknd 6697 39 anti anti NNS cord-010119-t1x9gknd 6697 40 - - NN cord-010119-t1x9gknd 6697 41 f f NNP cord-010119-t1x9gknd 6697 42 . . . cord-010119-t1x9gknd 6697 43 _SP cord-010119-t1x9gknd 6698 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 6699 1 Study Study NNP cord-010119-t1x9gknd 6699 2 Design Design NNP cord-010119-t1x9gknd 6699 3 / / SYM cord-010119-t1x9gknd 6699 4 Method method NN cord-010119-t1x9gknd 6699 5 : : : cord-010119-t1x9gknd 6700 1 Antibody antibody NN cord-010119-t1x9gknd 6700 2 screen screen NN cord-010119-t1x9gknd 6700 3 and and CC cord-010119-t1x9gknd 6700 4 compatibility compatibility NN cord-010119-t1x9gknd 6700 5 testing testing NN cord-010119-t1x9gknd 6700 6 was be VBD cord-010119-t1x9gknd 6700 7 performed perform VBN cord-010119-t1x9gknd 6700 8 by by IN cord-010119-t1x9gknd 6700 9 automated automate VBN cord-010119-t1x9gknd 6700 10 solid solid JJ cord-010119-t1x9gknd 6700 11 phase phase NN cord-010119-t1x9gknd 6700 12 ( ( -LRB- cord-010119-t1x9gknd 6700 13 Echo Echo NNP cord-010119-t1x9gknd 6700 14 and and CC cord-010119-t1x9gknd 6700 15 Neo Neo NNP cord-010119-t1x9gknd 6700 16 , , , cord-010119-t1x9gknd 6700 17 lmmucor lmmucor NNP cord-010119-t1x9gknd 6700 18 , , , cord-010119-t1x9gknd 6700 19 Inc Inc NNP cord-010119-t1x9gknd 6700 20 ) ) -RRB- cord-010119-t1x9gknd 6700 21 . . . cord-010119-t1x9gknd 6701 1 Red red JJ cord-010119-t1x9gknd 6701 2 cell cell NN cord-010119-t1x9gknd 6701 3 phenotyping phenotyping NN cord-010119-t1x9gknd 6701 4 was be VBD cord-010119-t1x9gknd 6701 5 done do VBN cord-010119-t1x9gknd 6701 6 by by IN cord-010119-t1x9gknd 6701 7 standard standard JJ cord-010119-t1x9gknd 6701 8 tube tube NN cord-010119-t1x9gknd 6701 9 testing testing NN cord-010119-t1x9gknd 6701 10 with with IN cord-010119-t1x9gknd 6701 11 commercial commercial JJ cord-010119-t1x9gknd 6701 12 reagents reagent NNS cord-010119-t1x9gknd 6701 13 following follow VBG cord-010119-t1x9gknd 6701 14 the the DT cord-010119-t1x9gknd 6701 15 manufacturers manufacturer NNS cord-010119-t1x9gknd 6701 16 instructions instruction NNS cord-010119-t1x9gknd 6701 17 . . . cord-010119-t1x9gknd 6702 1 Molecular molecular JJ cord-010119-t1x9gknd 6702 2 genotyping genotyping NN cord-010119-t1x9gknd 6702 3 was be VBD cord-010119-t1x9gknd 6702 4 performed perform VBN cord-010119-t1x9gknd 6702 5 using use VBG cord-010119-t1x9gknd 6702 6 the the DT cord-010119-t1x9gknd 6702 7 Bloodchip Bloodchip NNP cord-010119-t1x9gknd 6702 8 assay assay NN cord-010119-t1x9gknd 6702 9 ( ( -LRB- cord-010119-t1x9gknd 6702 10 Grifols Grifols NNP cord-010119-t1x9gknd 6702 11 , , , cord-010119-t1x9gknd 6702 12 San San NNP cord-010119-t1x9gknd 6702 13 Marcos Marcos NNP cord-010119-t1x9gknd 6702 14 TX TX NNP cord-010119-t1x9gknd 6702 15 ) ) -RRB- cord-010119-t1x9gknd 6702 16 . . . cord-010119-t1x9gknd 6703 1 Elution Elution NNP cord-010119-t1x9gknd 6703 2 studies study NNS cord-010119-t1x9gknd 6703 3 were be VBD cord-010119-t1x9gknd 6703 4 performed perform VBN cord-010119-t1x9gknd 6703 5 using use VBG cord-010119-t1x9gknd 6703 6 the the DT cord-010119-t1x9gknd 6703 7 ELU ELU NNP cord-010119-t1x9gknd 6703 8 - - HYPH cord-010119-t1x9gknd 6703 9 Kit Kit NNP cord-010119-t1x9gknd 6703 10 II II NNP cord-010119-t1x9gknd 6703 11 ( ( -LRB- cord-010119-t1x9gknd 6703 12 lmmucor lmmucor NNP cord-010119-t1x9gknd 6703 13 , , , cord-010119-t1x9gknd 6703 14 Inc. Inc. NNP cord-010119-t1x9gknd 6703 15 ) ) -RRB- cord-010119-t1x9gknd 6703 16 Results/ Results/ . cord-010119-t1x9gknd 6704 1 Finding finding NN cord-010119-t1x9gknd 6704 2 : : : cord-010119-t1x9gknd 6705 1 The the DT cord-010119-t1x9gknd 6705 2 initial initial JJ cord-010119-t1x9gknd 6705 3 antibody antibody NN cord-010119-t1x9gknd 6705 4 screen screen NN cord-010119-t1x9gknd 6705 5 ( ( -LRB- cord-010119-t1x9gknd 6705 6 AS AS NNP cord-010119-t1x9gknd 6705 7 ) ) -RRB- cord-010119-t1x9gknd 6705 8 was be VBD cord-010119-t1x9gknd 6705 9 negative negative JJ cord-010119-t1x9gknd 6705 10 and and CC cord-010119-t1x9gknd 6705 11 the the DT cord-010119-t1x9gknd 6705 12 patient patient NN cord-010119-t1x9gknd 6705 13 was be VBD cord-010119-t1x9gknd 6705 14 transfused transfuse VBN cord-010119-t1x9gknd 6705 15 1 1 CD cord-010119-t1x9gknd 6705 16 unit unit NN cord-010119-t1x9gknd 6705 17 O o NN cord-010119-t1x9gknd 6705 18 - - HYPH cord-010119-t1x9gknd 6705 19 RBCs rbc NNS cord-010119-t1x9gknd 6705 20 . . . cord-010119-t1x9gknd 6706 1 Two two CD cord-010119-t1x9gknd 6706 2 weeks week NNS cord-010119-t1x9gknd 6706 3 later later RB cord-010119-t1x9gknd 6706 4 the the DT cord-010119-t1x9gknd 6706 5 patient patient NN cord-010119-t1x9gknd 6706 6 received receive VBD cord-010119-t1x9gknd 6706 7 an an DT cord-010119-t1x9gknd 6706 8 additional additional JJ cord-010119-t1x9gknd 6706 9 O O NNP cord-010119-t1x9gknd 6706 10 - - HYPH cord-010119-t1x9gknd 6706 11 RBC rbc NN cord-010119-t1x9gknd 6706 12 . . . cord-010119-t1x9gknd 6707 1 Within within IN cord-010119-t1x9gknd 6707 2 4 4 CD cord-010119-t1x9gknd 6707 3 days day NNS cord-010119-t1x9gknd 6707 4 the the DT cord-010119-t1x9gknd 6707 5 Hgb Hgb NNP cord-010119-t1x9gknd 6707 6 had have VBD cord-010119-t1x9gknd 6707 7 decreased decrease VBN cord-010119-t1x9gknd 6707 8 from from IN cord-010119-t1x9gknd 6707 9 8.3 8.3 CD cord-010119-t1x9gknd 6707 10 to to IN cord-010119-t1x9gknd 6707 11 7.1 7.1 CD cord-010119-t1x9gknd 6707 12 g g NN cord-010119-t1x9gknd 6707 13 / / SYM cord-010119-t1x9gknd 6707 14 dl dl NNP cord-010119-t1x9gknd 6707 15 , , , cord-010119-t1x9gknd 6707 16 the the DT cord-010119-t1x9gknd 6707 17 AS AS NNP cord-010119-t1x9gknd 6707 18 and and CC cord-010119-t1x9gknd 6707 19 Direct Direct NNP cord-010119-t1x9gknd 6707 20 Antiglobulin Antiglobulin NNP cord-010119-t1x9gknd 6707 21 Test test NN cord-010119-t1x9gknd 6707 22 ( ( -LRB- cord-010119-t1x9gknd 6707 23 DAT DAT NNP cord-010119-t1x9gknd 6707 24 ) ) -RRB- cord-010119-t1x9gknd 6707 25 were be VBD cord-010119-t1x9gknd 6707 26 now now RB cord-010119-t1x9gknd 6707 27 positive positive JJ cord-010119-t1x9gknd 6707 28 , , , cord-010119-t1x9gknd 6707 29 and and CC cord-010119-t1x9gknd 6707 30 Ounits Ounits NNPS cord-010119-t1x9gknd 6707 31 were be VBD cord-010119-t1x9gknd 6707 32 incompatible incompatible JJ cord-010119-t1x9gknd 6707 33 . . . cord-010119-t1x9gknd 6708 1 Anti Anti NNP cord-010119-t1x9gknd 6708 2 - - NNP cord-010119-t1x9gknd 6708 3 f f NNP cord-010119-t1x9gknd 6708 4 was be VBD cord-010119-t1x9gknd 6708 5 identified identify VBN cord-010119-t1x9gknd 6708 6 in in IN cord-010119-t1x9gknd 6708 7 the the DT cord-010119-t1x9gknd 6708 8 patient patient NN cord-010119-t1x9gknd 6708 9 's 's POS cord-010119-t1x9gknd 6708 10 plasma plasma NN cord-010119-t1x9gknd 6708 11 and and CC cord-010119-t1x9gknd 6708 12 eluate eluate NN cord-010119-t1x9gknd 6708 13 . . . cord-010119-t1x9gknd 6709 1 Three three CD cord-010119-t1x9gknd 6709 2 additional additional JJ cord-010119-t1x9gknd 6709 3 units unit NNS cord-010119-t1x9gknd 6709 4 were be VBD cord-010119-t1x9gknd 6709 5 requested request VBN cord-010119-t1x9gknd 6709 6 for for IN cord-010119-t1x9gknd 6709 7 transfusion transfusion NN cord-010119-t1x9gknd 6709 8 . . . cord-010119-t1x9gknd 6710 1 Due due IN cord-010119-t1x9gknd 6710 2 to to IN cord-010119-t1x9gknd 6710 3 the the DT cord-010119-t1x9gknd 6710 4 rarity rarity NN cord-010119-t1x9gknd 6710 5 of of IN cord-010119-t1x9gknd 6710 6 O o NN cord-010119-t1x9gknd 6710 7 - - HYPH cord-010119-t1x9gknd 6710 8 f f NN cord-010119-t1x9gknd 6710 9 - - HYPH cord-010119-t1x9gknd 6710 10 RBCs rbc NNS cord-010119-t1x9gknd 6710 11 , , , cord-010119-t1x9gknd 6710 12 the the DT cord-010119-t1x9gknd 6710 13 patient patient NN cord-010119-t1x9gknd 6710 14 was be VBD cord-010119-t1x9gknd 6710 15 transfused transfuse VBN cord-010119-t1x9gknd 6710 16 3 3 CD cord-010119-t1x9gknd 6710 17 R r NN cord-010119-t1x9gknd 6710 18 1 1 CD cord-010119-t1x9gknd 6710 19 R r NN cord-010119-t1x9gknd 6710 20 1 1 CD cord-010119-t1x9gknd 6710 21 ( ( -LRB- cord-010119-t1x9gknd 6710 22 DCe DCe NNP cord-010119-t1x9gknd 6710 23 / / SYM cord-010119-t1x9gknd 6710 24 DCe DCe NNS cord-010119-t1x9gknd 6710 25 ) ) -RRB- cord-010119-t1x9gknd 6710 26 RBCs rbc NNS cord-010119-t1x9gknd 6710 27 with with IN cord-010119-t1x9gknd 6710 28 no no DT cord-010119-t1x9gknd 6710 29 reported report VBN cord-010119-t1x9gknd 6710 30 complications complication NNS cord-010119-t1x9gknd 6710 31 . . . cord-010119-t1x9gknd 6711 1 The the DT cord-010119-t1x9gknd 6711 2 patient patient NN cord-010119-t1x9gknd 6711 3 was be VBD cord-010119-t1x9gknd 6711 4 discharged discharge VBN cord-010119-t1x9gknd 6711 5 to to TO cord-010119-t1x9gknd 6711 6 follow follow VB cord-010119-t1x9gknd 6711 7 up up RP cord-010119-t1x9gknd 6711 8 in in IN cord-010119-t1x9gknd 6711 9 clinic clinic NN cord-010119-t1x9gknd 6711 10 . . . cord-010119-t1x9gknd 6712 1 Molecular molecular JJ cord-010119-t1x9gknd 6712 2 genotyping genotyping NN cord-010119-t1x9gknd 6712 3 showed show VBD cord-010119-t1x9gknd 6712 4 the the DT cord-010119-t1x9gknd 6712 5 patient patient NN cord-010119-t1x9gknd 6712 6 was be VBD cord-010119-t1x9gknd 6712 7 RhD RhD NNP cord-010119-t1x9gknd 6712 8 deleted delete VBN cord-010119-t1x9gknd 6712 9 ( ( -LRB- cord-010119-t1x9gknd 6712 10 RHO RHO NNP cord-010119-t1x9gknd 6712 11 * * NFP cord-010119-t1x9gknd 6712 12 del del NN cord-010119-t1x9gknd 6712 13 ) ) -RRB- cord-010119-t1x9gknd 6712 14 and and CC cord-010119-t1x9gknd 6712 15 had have VBD cord-010119-t1x9gknd 6712 16 normal normal JJ cord-010119-t1x9gknd 6712 17 RHCE RHCE NNP cord-010119-t1x9gknd 6712 18 ( ( -LRB- cord-010119-t1x9gknd 6712 19 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 6712 20 / / SYM cord-010119-t1x9gknd 6712 21 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 6712 22 ) ) -RRB- cord-010119-t1x9gknd 6712 23 genes gene NNS cord-010119-t1x9gknd 6712 24 which which WDT cord-010119-t1x9gknd 6712 25 predict predict VBP cord-010119-t1x9gknd 6712 26 a a DT cord-010119-t1x9gknd 6712 27 D d NN cord-010119-t1x9gknd 6712 28 - - HYPH cord-010119-t1x9gknd 6712 29 C c NN cord-010119-t1x9gknd 6712 30 - - HYPH cord-010119-t1x9gknd 6712 31 E E NNP cord-010119-t1x9gknd 6712 32 - - HYPH cord-010119-t1x9gknd 6712 33 c1e1f1 c1e1f1 JJ cord-010119-t1x9gknd 6712 34 phenotype phenotype NN cord-010119-t1x9gknd 6712 35 . . . cord-010119-t1x9gknd 6713 1 The the DT cord-010119-t1x9gknd 6713 2 Rh Rh NNP cord-010119-t1x9gknd 6713 3 phenotype phenotype NN cord-010119-t1x9gknd 6713 4 and and CC cord-010119-t1x9gknd 6713 5 AS AS NNP cord-010119-t1x9gknd 6713 6 was be VBD cord-010119-t1x9gknd 6713 7 repeated repeat VBN cord-010119-t1x9gknd 6713 8 on on IN cord-010119-t1x9gknd 6713 9 a a DT cord-010119-t1x9gknd 6713 10 sample sample NN cord-010119-t1x9gknd 6713 11 collected collect VBN cord-010119-t1x9gknd 6713 12 18 18 CD cord-010119-t1x9gknd 6713 13 days day NNS cord-010119-t1x9gknd 6713 14 later later RB cord-010119-t1x9gknd 6713 15 . . . cord-010119-t1x9gknd 6714 1 The the DT cord-010119-t1x9gknd 6714 2 C C NNP cord-010119-t1x9gknd 6714 3 typing typing NN cord-010119-t1x9gknd 6714 4 was be VBD cord-010119-t1x9gknd 6714 5 micro micro JJ cord-010119-t1x9gknd 6714 6 positive positive JJ cord-010119-t1x9gknd 6714 7 , , , cord-010119-t1x9gknd 6714 8 mixed mixed JJ cord-010119-t1x9gknd 6714 9 field field NN cord-010119-t1x9gknd 6714 10 only only RB cord-010119-t1x9gknd 6714 11 after after IN cord-010119-t1x9gknd 6714 12 5 5 CD cord-010119-t1x9gknd 6714 13 minute minute NN cord-010119-t1x9gknd 6714 14 incubation incubation NN cord-010119-t1x9gknd 6714 15 . . . cord-010119-t1x9gknd 6715 1 The the DT cord-010119-t1x9gknd 6715 2 other other JJ cord-010119-t1x9gknd 6715 3 Rh Rh NNP cord-010119-t1x9gknd 6715 4 antigens antigen NNS cord-010119-t1x9gknd 6715 5 were be VBD cord-010119-t1x9gknd 6715 6 not not RB cord-010119-t1x9gknd 6715 7 mixed mixed JJ cord-010119-t1x9gknd 6715 8 filed file VBN cord-010119-t1x9gknd 6715 9 , , , cord-010119-t1x9gknd 6715 10 and and CC cord-010119-t1x9gknd 6715 11 the the DT cord-010119-t1x9gknd 6715 12 AS AS NNP cord-010119-t1x9gknd 6715 13 was be VBD cord-010119-t1x9gknd 6715 14 non non AFX cord-010119-t1x9gknd 6715 15 reactive reactive JJ cord-010119-t1x9gknd 6715 16 . . . cord-010119-t1x9gknd 6716 1 However however RB cord-010119-t1x9gknd 6716 2 , , , cord-010119-t1x9gknd 6716 3 the the DT cord-010119-t1x9gknd 6716 4 DAT DAT NNP cord-010119-t1x9gknd 6716 5 was be VBD cord-010119-t1x9gknd 6716 6 weakly weakly RB cord-010119-t1x9gknd 6716 7 positive positive JJ cord-010119-t1x9gknd 6716 8 with with IN cord-010119-t1x9gknd 6716 9 anti anti JJ cord-010119-t1x9gknd 6716 10 - - NN cord-010119-t1x9gknd 6716 11 lgG. lgg. JJ cord-010119-t1x9gknd 6717 1 No no DT cord-010119-t1x9gknd 6717 2 elution elution NN cord-010119-t1x9gknd 6717 3 study study NN cord-010119-t1x9gknd 6717 4 was be VBD cord-010119-t1x9gknd 6717 5 performed perform VBN cord-010119-t1x9gknd 6717 6 . . . cord-010119-t1x9gknd 6718 1 Conclusion conclusion NN cord-010119-t1x9gknd 6718 2 : : : cord-010119-t1x9gknd 6719 1 The the DT cord-010119-t1x9gknd 6719 2 expected expect VBN cord-010119-t1x9gknd 6719 3 post post NN cord-010119-t1x9gknd 6719 4 24 24 CD cord-010119-t1x9gknd 6719 5 hour hour NN cord-010119-t1x9gknd 6719 6 Hgb Hgb NNP cord-010119-t1x9gknd 6719 7 increment increment NN cord-010119-t1x9gknd 6719 8 from from IN cord-010119-t1x9gknd 6719 9 the the DT cord-010119-t1x9gknd 6719 10 receipt receipt NN cord-010119-t1x9gknd 6719 11 of of IN cord-010119-t1x9gknd 6719 12 a a DT cord-010119-t1x9gknd 6719 13 standard standard JJ cord-010119-t1x9gknd 6719 14 unit unit NN cord-010119-t1x9gknd 6719 15 of of IN cord-010119-t1x9gknd 6719 16 blood blood NN cord-010119-t1x9gknd 6719 17 should should MD cord-010119-t1x9gknd 6719 18 be be VB cord-010119-t1x9gknd 6719 19 near near IN cord-010119-t1x9gknd 6719 20 1 1 CD cord-010119-t1x9gknd 6719 21 g g NN cord-010119-t1x9gknd 6719 22 / / SYM cord-010119-t1x9gknd 6719 23 dl dl NN cord-010119-t1x9gknd 6719 24 ( ( -LRB- cord-010119-t1x9gknd 6719 25 or or CC cord-010119-t1x9gknd 6719 26 3 3 CD cord-010119-t1x9gknd 6719 27 % % NN cord-010119-t1x9gknd 6719 28 Hct Hct NNP cord-010119-t1x9gknd 6719 29 . . . cord-010119-t1x9gknd 6719 30 ) ) -RRB- cord-010119-t1x9gknd 6720 1 Throughout throughout IN cord-010119-t1x9gknd 6720 2 this this DT cord-010119-t1x9gknd 6720 3 patients patient NNS cord-010119-t1x9gknd 6720 4 hospitalization hospitalization NN cord-010119-t1x9gknd 6720 5 , , , cord-010119-t1x9gknd 6720 6 the the DT cord-010119-t1x9gknd 6720 7 post post JJ cord-010119-t1x9gknd 6720 8 - - JJ cord-010119-t1x9gknd 6720 9 transfusion transfusion JJ cord-010119-t1x9gknd 6720 10 increments increment NNS cord-010119-t1x9gknd 6720 11 did do VBD cord-010119-t1x9gknd 6720 12 not not RB cord-010119-t1x9gknd 6720 13 fully fully RB cord-010119-t1x9gknd 6720 14 achieve achieve VB cord-010119-t1x9gknd 6720 15 this this DT cord-010119-t1x9gknd 6720 16 expectation expectation NN cord-010119-t1x9gknd 6720 17 . . . cord-010119-t1x9gknd 6721 1 The the DT cord-010119-t1x9gknd 6721 2 first first JJ cord-010119-t1x9gknd 6721 3 transfuion transfuion NN cord-010119-t1x9gknd 6721 4 resulted result VBD cord-010119-t1x9gknd 6721 5 in in IN cord-010119-t1x9gknd 6721 6 a a DT cord-010119-t1x9gknd 6721 7 0.9 0.9 CD cord-010119-t1x9gknd 6721 8 g g NN cord-010119-t1x9gknd 6721 9 / / SYM cord-010119-t1x9gknd 6721 10 dl dl NN cord-010119-t1x9gknd 6721 11 increase increase NN cord-010119-t1x9gknd 6721 12 , , , cord-010119-t1x9gknd 6721 13 and and CC cord-010119-t1x9gknd 6721 14 the the DT cord-010119-t1x9gknd 6721 15 second second JJ cord-010119-t1x9gknd 6721 16 unit unit NN cord-010119-t1x9gknd 6721 17 was be VBD cord-010119-t1x9gknd 6721 18 only only RB cord-010119-t1x9gknd 6721 19 0.5 0.5 CD cord-010119-t1x9gknd 6721 20 g g NN cord-010119-t1x9gknd 6721 21 / / SYM cord-010119-t1x9gknd 6721 22 dl dl NN cord-010119-t1x9gknd 6721 23 . . . cord-010119-t1x9gknd 6722 1 The the DT cord-010119-t1x9gknd 6722 2 last last JJ cord-010119-t1x9gknd 6722 3 transfusion transfusion NN cord-010119-t1x9gknd 6722 4 of of IN cord-010119-t1x9gknd 6722 5 3 3 CD cord-010119-t1x9gknd 6722 6 units unit NNS cord-010119-t1x9gknd 6722 7 increased increase VBN cord-010119-t1x9gknd 6722 8 by by IN cord-010119-t1x9gknd 6722 9 only only RB cord-010119-t1x9gknd 6722 10 1.2 1.2 CD cord-010119-t1x9gknd 6722 11 g g NN cord-010119-t1x9gknd 6722 12 / / SYM cord-010119-t1x9gknd 6722 13 dl dl NN cord-010119-t1x9gknd 6722 14 . . . cord-010119-t1x9gknd 6723 1 Less Less JJR cord-010119-t1x9gknd 6723 2 than than IN cord-010119-t1x9gknd 6723 3 three three CD cord-010119-t1x9gknd 6723 4 weeks week NNS cord-010119-t1x9gknd 6723 5 later later RB cord-010119-t1x9gknd 6723 6 , , , cord-010119-t1x9gknd 6723 7 the the DT cord-010119-t1x9gknd 6723 8 RhC rhc NN cord-010119-t1x9gknd 6723 9 antigen antigen NN cord-010119-t1x9gknd 6723 10 typing typing NN cord-010119-t1x9gknd 6723 11 was be VBD cord-010119-t1x9gknd 6723 12 microscopic microscopic JJ cord-010119-t1x9gknd 6723 13 / / SYM cord-010119-t1x9gknd 6723 14 mixed mixed JJ cord-010119-t1x9gknd 6723 15 field field NN cord-010119-t1x9gknd 6723 16 only only RB cord-010119-t1x9gknd 6723 17 after after IN cord-010119-t1x9gknd 6723 18 extended extended JJ cord-010119-t1x9gknd 6723 19 incubation incubation NN cord-010119-t1x9gknd 6723 20 , , , cord-010119-t1x9gknd 6723 21 indicating indicate VBG cord-010119-t1x9gknd 6723 22 the the DT cord-010119-t1x9gknd 6723 23 removal removal NN cord-010119-t1x9gknd 6723 24 of of IN cord-010119-t1x9gknd 6723 25 3 3 CD cord-010119-t1x9gknd 6723 26 R r NN cord-010119-t1x9gknd 6723 27 1 1 CD cord-010119-t1x9gknd 6723 28 R r NN cord-010119-t1x9gknd 6723 29 1 1 CD cord-010119-t1x9gknd 6723 30 units unit NNS cord-010119-t1x9gknd 6723 31 was be VBD cord-010119-t1x9gknd 6723 32 nearly nearly RB cord-010119-t1x9gknd 6723 33 complete complete JJ cord-010119-t1x9gknd 6723 34 . . . cord-010119-t1x9gknd 6724 1 In in IN cord-010119-t1x9gknd 6724 2 a a DT cord-010119-t1x9gknd 6724 3 case case NN cord-010119-t1x9gknd 6724 4 from from IN cord-010119-t1x9gknd 6724 5 1989 1989 CD cord-010119-t1x9gknd 6724 6 , , , cord-010119-t1x9gknd 6724 7 Ohto Ohto NNP cord-010119-t1x9gknd 6724 8 and and CC cord-010119-t1x9gknd 6724 9 Kariyone Kariyone NNP cord-010119-t1x9gknd 6724 10 ( ( -LRB- cord-010119-t1x9gknd 6724 11 Transf Transf NNP cord-010119-t1x9gknd 6724 12 . . . cord-010119-t1x9gknd 6724 13 1989 1989 CD cord-010119-t1x9gknd 6724 14 ; ; : cord-010119-t1x9gknd 6724 15 Vol29 Vol29 NNP cord-010119-t1x9gknd 6724 16 , , , cord-010119-t1x9gknd 6724 17 No no NN cord-010119-t1x9gknd 6724 18 . . NN cord-010119-t1x9gknd 6724 19 3 3 LS cord-010119-t1x9gknd 6724 20 ) ) -RRB- cord-010119-t1x9gknd 6724 21 reported report VBD cord-010119-t1x9gknd 6724 22 a a DT cord-010119-t1x9gknd 6724 23 51 51 CD cord-010119-t1x9gknd 6724 24 Cr Cr NNP cord-010119-t1x9gknd 6724 25 Ásurvival Ásurvival NNP cord-010119-t1x9gknd 6724 26 study study NN cord-010119-t1x9gknd 6724 27 of of IN cord-010119-t1x9gknd 6724 28 f1 f1 NNP cord-010119-t1x9gknd 6724 29 RBCs rbc NNS cord-010119-t1x9gknd 6724 30 in in IN cord-010119-t1x9gknd 6724 31 a a DT cord-010119-t1x9gknd 6724 32 patient patient NN cord-010119-t1x9gknd 6724 33 with with IN cord-010119-t1x9gknd 6724 34 anti anti JJ cord-010119-t1x9gknd 6724 35 - - NN cord-010119-t1x9gknd 6724 36 f f NN cord-010119-t1x9gknd 6724 37 . . . cord-010119-t1x9gknd 6725 1 They -PRON- PRP cord-010119-t1x9gknd 6725 2 showed show VBD cord-010119-t1x9gknd 6725 3 that that IN cord-010119-t1x9gknd 6725 4 the the DT cord-010119-t1x9gknd 6725 5 initital initital JJ cord-010119-t1x9gknd 6725 6 survival survival NN cord-010119-t1x9gknd 6725 7 of of IN cord-010119-t1x9gknd 6725 8 f1 f1 NN cord-010119-t1x9gknd 6725 9 cells cell NNS cord-010119-t1x9gknd 6725 10 was be VBD cord-010119-t1x9gknd 6725 11 fairly fairly RB cord-010119-t1x9gknd 6725 12 normal normal JJ cord-010119-t1x9gknd 6725 13 , , , cord-010119-t1x9gknd 6725 14 however however RB cord-010119-t1x9gknd 6725 15 , , , cord-010119-t1x9gknd 6725 16 after after IN cord-010119-t1x9gknd 6725 17 18 18 CD cord-010119-t1x9gknd 6725 18 days day NNS cord-010119-t1x9gknd 6725 19 , , , cord-010119-t1x9gknd 6725 20 there there EX cord-010119-t1x9gknd 6725 21 was be VBD cord-010119-t1x9gknd 6725 22 a a DT cord-010119-t1x9gknd 6725 23 sudden sudden JJ cord-010119-t1x9gknd 6725 24 increase increase NN cord-010119-t1x9gknd 6725 25 of of IN cord-010119-t1x9gknd 6725 26 red red JJ cord-010119-t1x9gknd 6725 27 cell cell NN cord-010119-t1x9gknd 6725 28 destruction destruction NN cord-010119-t1x9gknd 6725 29 , , , cord-010119-t1x9gknd 6725 30 and and CC cord-010119-t1x9gknd 6725 31 by by IN cord-010119-t1x9gknd 6725 32 day day NN cord-010119-t1x9gknd 6725 33 27 27 CD cord-010119-t1x9gknd 6725 34 all all DT cord-010119-t1x9gknd 6725 35 f1 f1 NN cord-010119-t1x9gknd 6725 36 cells cell NNS cord-010119-t1x9gknd 6725 37 were be VBD cord-010119-t1x9gknd 6725 38 cleared clear VBN cord-010119-t1x9gknd 6725 39 from from IN cord-010119-t1x9gknd 6725 40 the the DT cord-010119-t1x9gknd 6725 41 circulation circulation NN cord-010119-t1x9gknd 6725 42 . . . cord-010119-t1x9gknd 6726 1 It -PRON- PRP cord-010119-t1x9gknd 6726 2 is be VBZ cord-010119-t1x9gknd 6726 3 not not RB cord-010119-t1x9gknd 6726 4 unusual unusual JJ cord-010119-t1x9gknd 6726 5 to to TO cord-010119-t1x9gknd 6726 6 find find VB cord-010119-t1x9gknd 6726 7 auto auto NN cord-010119-t1x9gknd 6726 8 - - HYPH cord-010119-t1x9gknd 6726 9 anti anti NN cord-010119-t1x9gknd 6726 10 - - NN cord-010119-t1x9gknd 6726 11 f f JJ cord-010119-t1x9gknd 6726 12 as as IN cord-010119-t1x9gknd 6726 13 many many JJ cord-010119-t1x9gknd 6726 14 have have VBP cord-010119-t1x9gknd 6726 15 been be VBN cord-010119-t1x9gknd 6726 16 reported report VBN cord-010119-t1x9gknd 6726 17 , , , cord-010119-t1x9gknd 6726 18 however however RB cord-010119-t1x9gknd 6726 19 , , , cord-010119-t1x9gknd 6726 20 it -PRON- PRP cord-010119-t1x9gknd 6726 21 is be VBZ cord-010119-t1x9gknd 6726 22 unusual unusual JJ cord-010119-t1x9gknd 6726 23 to to TO cord-010119-t1x9gknd 6726 24 find find VB cord-010119-t1x9gknd 6726 25 the the DT cord-010119-t1x9gknd 6726 26 auto auto NN cord-010119-t1x9gknd 6726 27 - - HYPH cord-010119-t1x9gknd 6726 28 antibody antibody NN cord-010119-t1x9gknd 6726 29 has have VBZ cord-010119-t1x9gknd 6726 30 caused cause VBN cord-010119-t1x9gknd 6726 31 the the DT cord-010119-t1x9gknd 6726 32 clearance clearance NN cord-010119-t1x9gknd 6726 33 of of IN cord-010119-t1x9gknd 6726 34 three three CD cord-010119-t1x9gknd 6726 35 units unit NNS cord-010119-t1x9gknd 6726 36 of of IN cord-010119-t1x9gknd 6726 37 f f NNP cord-010119-t1x9gknd 6726 38 - - HYPH cord-010119-t1x9gknd 6726 39 negative negative JJ cord-010119-t1x9gknd 6726 40 blood blood NN cord-010119-t1x9gknd 6726 41 . . . cord-010119-t1x9gknd 6727 1 This this DT cord-010119-t1x9gknd 6727 2 patient patient NN cord-010119-t1x9gknd 6727 3 will will MD cord-010119-t1x9gknd 6727 4 be be VB cord-010119-t1x9gknd 6727 5 monitored monitor VBN cord-010119-t1x9gknd 6727 6 to to TO cord-010119-t1x9gknd 6727 7 see see VB cord-010119-t1x9gknd 6727 8 if if IN cord-010119-t1x9gknd 6727 9 the the DT cord-010119-t1x9gknd 6727 10 autoantibody autoantibody NN cord-010119-t1x9gknd 6727 11 recurs recur VBZ cord-010119-t1x9gknd 6727 12 and and CC cord-010119-t1x9gknd 6727 13 determine determine VBP cord-010119-t1x9gknd 6727 14 if if IN cord-010119-t1x9gknd 6727 15 it -PRON- PRP cord-010119-t1x9gknd 6727 16 still still RB cord-010119-t1x9gknd 6727 17 has have VBZ cord-010119-t1x9gknd 6727 18 anti anti JJ cord-010119-t1x9gknd 6727 19 - - JJ cord-010119-t1x9gknd 6727 20 f f JJ cord-010119-t1x9gknd 6727 21 specificity specificity NN cord-010119-t1x9gknd 6727 22 . . . cord-010119-t1x9gknd 6728 1 Background Background NNP cord-010119-t1x9gknd 6728 2 / / SYM cord-010119-t1x9gknd 6728 3 Case Case NNP cord-010119-t1x9gknd 6728 4 Studies Studies NNPS cord-010119-t1x9gknd 6728 5 : : : cord-010119-t1x9gknd 6729 1 Use Use NNP cord-010119-t1x9gknd 6729 2 of of IN cord-010119-t1x9gknd 6729 3 dithiothreitol dithiothreitol NNP cord-010119-t1x9gknd 6729 4 ( ( -LRB- cord-010119-t1x9gknd 6729 5 DTT DTT NNP cord-010119-t1x9gknd 6729 6 ) ) -RRB- cord-010119-t1x9gknd 6729 7 treated treat VBD cord-010119-t1x9gknd 6729 8 reagent reagent NN cord-010119-t1x9gknd 6729 9 red red JJ cord-010119-t1x9gknd 6729 10 cells cell NNS cord-010119-t1x9gknd 6729 11 ( ( -LRB- cord-010119-t1x9gknd 6729 12 RRBC RRBC NNP cord-010119-t1x9gknd 6729 13 ) ) -RRB- cord-010119-t1x9gknd 6729 14 is be VBZ cord-010119-t1x9gknd 6729 15 increasing increase VBG cord-010119-t1x9gknd 6729 16 in in IN cord-010119-t1x9gknd 6729 17 blood blood NN cord-010119-t1x9gknd 6729 18 banks bank NNS cord-010119-t1x9gknd 6729 19 as as IN cord-010119-t1x9gknd 6729 20 an an DT cord-010119-t1x9gknd 6729 21 effective effective JJ cord-010119-t1x9gknd 6729 22 way way NN cord-010119-t1x9gknd 6729 23 to to TO cord-010119-t1x9gknd 6729 24 negate negate VB cord-010119-t1x9gknd 6729 25 the the DT cord-010119-t1x9gknd 6729 26 interfering interfere VBG cord-010119-t1x9gknd 6729 27 panreactivity panreactivity NN cord-010119-t1x9gknd 6729 28 caused cause VBN cord-010119-t1x9gknd 6729 29 by by IN cord-010119-t1x9gknd 6729 30 Daratumumab Daratumumab NNP cord-010119-t1x9gknd 6729 31 , , , cord-010119-t1x9gknd 6729 32 an an DT cord-010119-t1x9gknd 6729 33 anti anti JJ cord-010119-t1x9gknd 6729 34 - - JJ cord-010119-t1x9gknd 6729 35 CD38 cd38 JJ cord-010119-t1x9gknd 6729 36 drug drug NN cord-010119-t1x9gknd 6729 37 for for IN cord-010119-t1x9gknd 6729 38 treatment treatment NN cord-010119-t1x9gknd 6729 39 of of IN cord-010119-t1x9gknd 6729 40 multiple multiple JJ cord-010119-t1x9gknd 6729 41 myeloma myeloma NN cord-010119-t1x9gknd 6729 42 . . . cord-010119-t1x9gknd 6730 1 Daily daily JJ cord-010119-t1x9gknd 6730 2 preparation preparation NN cord-010119-t1x9gknd 6730 3 of of IN cord-010119-t1x9gknd 6730 4 DTT DTT NNP cord-010119-t1x9gknd 6730 5 - - HYPH cord-010119-t1x9gknd 6730 6 treated treat VBN cord-010119-t1x9gknd 6730 7 RRBC RRBC NNP cord-010119-t1x9gknd 6730 8 for for IN cord-010119-t1x9gknd 6730 9 testing testing NN cord-010119-t1x9gknd 6730 10 of of IN cord-010119-t1x9gknd 6730 11 individual individual JJ cord-010119-t1x9gknd 6730 12 patients patient NNS cord-010119-t1x9gknd 6730 13 is be VBZ cord-010119-t1x9gknd 6730 14 burdensome burdensome JJ cord-010119-t1x9gknd 6730 15 for for IN cord-010119-t1x9gknd 6730 16 the the DT cord-010119-t1x9gknd 6730 17 laboratory laboratory NN cord-010119-t1x9gknd 6730 18 and and CC cord-010119-t1x9gknd 6730 19 may may MD cord-010119-t1x9gknd 6730 20 delay delay VB cord-010119-t1x9gknd 6730 21 patient patient JJ cord-010119-t1x9gknd 6730 22 care care NN cord-010119-t1x9gknd 6730 23 . . . cord-010119-t1x9gknd 6731 1 We -PRON- PRP cord-010119-t1x9gknd 6731 2 evaluated evaluate VBD cord-010119-t1x9gknd 6731 3 the the DT cord-010119-t1x9gknd 6731 4 effectiveness effectiveness NN cord-010119-t1x9gknd 6731 5 of of IN cord-010119-t1x9gknd 6731 6 batch batch NN cord-010119-t1x9gknd 6731 7 - - HYPH cord-010119-t1x9gknd 6731 8 prepared prepared JJ cord-010119-t1x9gknd 6731 9 DTT DTT NNP cord-010119-t1x9gknd 6731 10 - - HYPH cord-010119-t1x9gknd 6731 11 treated treat VBN cord-010119-t1x9gknd 6731 12 RRBC RRBC NNP cord-010119-t1x9gknd 6731 13 , , , cord-010119-t1x9gknd 6731 14 stored store VBN cord-010119-t1x9gknd 6731 15 up up RP cord-010119-t1x9gknd 6731 16 to to TO cord-010119-t1x9gknd 6731 17 9 9 CD cord-010119-t1x9gknd 6731 18 days day NNS cord-010119-t1x9gknd 6731 19 after after IN cord-010119-t1x9gknd 6731 20 treatment treatment NN cord-010119-t1x9gknd 6731 21 , , , cord-010119-t1x9gknd 6731 22 in in IN cord-010119-t1x9gknd 6731 23 antibody antibody NN cord-010119-t1x9gknd 6731 24 detection detection NN cord-010119-t1x9gknd 6731 25 tests test NNS cord-010119-t1x9gknd 6731 26 . . . cord-010119-t1x9gknd 6732 1 Study Study NNP cord-010119-t1x9gknd 6732 2 Design Design NNP cord-010119-t1x9gknd 6732 3 / / SYM cord-010119-t1x9gknd 6732 4 Methods method NNS cord-010119-t1x9gknd 6732 5 : : : cord-010119-t1x9gknd 6732 6 In in IN cord-010119-t1x9gknd 6732 7 - - HYPH cord-010119-t1x9gknd 6732 8 date date NN cord-010119-t1x9gknd 6732 9 RRBC RRBC NNP cord-010119-t1x9gknd 6733 1 ( ( -LRB- cord-010119-t1x9gknd 6733 2 Ortho Ortho NNP cord-010119-t1x9gknd 6733 3 Clinical Clinical NNP cord-010119-t1x9gknd 6733 4 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 6733 5 , , , cord-010119-t1x9gknd 6733 6 Raritan Raritan NNP cord-010119-t1x9gknd 6733 7 NJ NJ NNP cord-010119-t1x9gknd 6733 8 ) ) -RRB- cord-010119-t1x9gknd 6733 9 were be VBD cord-010119-t1x9gknd 6733 10 selected select VBN cord-010119-t1x9gknd 6733 11 based base VBN cord-010119-t1x9gknd 6733 12 on on IN cord-010119-t1x9gknd 6733 13 phenotype phenotype NN cord-010119-t1x9gknd 6733 14 to to TO cord-010119-t1x9gknd 6733 15 match match VB cord-010119-t1x9gknd 6733 16 the the DT cord-010119-t1x9gknd 6733 17 antisera antisera NN cord-010119-t1x9gknd 6733 18 to to TO cord-010119-t1x9gknd 6733 19 be be VB cord-010119-t1x9gknd 6733 20 tested test VBN cord-010119-t1x9gknd 6733 21 . . . cord-010119-t1x9gknd 6734 1 RRBC RRBC NNP cord-010119-t1x9gknd 6734 2 were be VBD cord-010119-t1x9gknd 6734 3 treated treat VBN cord-010119-t1x9gknd 6734 4 with with IN cord-010119-t1x9gknd 6734 5 0.2 0.2 CD cord-010119-t1x9gknd 6734 6 M M NNP cord-010119-t1x9gknd 6734 7 DTT DTT NNP cord-010119-t1x9gknd 6734 8 ( ( -LRB- cord-010119-t1x9gknd 6734 9 Sigma Sigma NNP cord-010119-t1x9gknd 6734 10 - - HYPH cord-010119-t1x9gknd 6734 11 Aldrich Aldrich NNP cord-010119-t1x9gknd 6734 12 , , , cord-010119-t1x9gknd 6734 13 St. St. NNP cord-010119-t1x9gknd 6734 14 Louis Louis NNP cord-010119-t1x9gknd 6734 15 MO MO NNP cord-010119-t1x9gknd 6734 16 ) ) -RRB- cord-010119-t1x9gknd 6734 17 and and CC cord-010119-t1x9gknd 6734 18 stored store VBN cord-010119-t1x9gknd 6734 19 in in IN cord-010119-t1x9gknd 6734 20 reagent reagent JJ cord-010119-t1x9gknd 6734 21 red red JJ cord-010119-t1x9gknd 6734 22 cell cell NN cord-010119-t1x9gknd 6734 23 diluent diluent NN cord-010119-t1x9gknd 6734 24 . . . cord-010119-t1x9gknd 6735 1 RRBC RRBC NNP cord-010119-t1x9gknd 6735 2 were be VBD cord-010119-t1x9gknd 6735 3 tested test VBN cord-010119-t1x9gknd 6735 4 with with IN cord-010119-t1x9gknd 6735 5 commercial commercial JJ cord-010119-t1x9gknd 6735 6 antisera antisera NN cord-010119-t1x9gknd 6735 7 ( ( -LRB- cord-010119-t1x9gknd 6735 8 Ortho Ortho NNP cord-010119-t1x9gknd 6735 9 Clinical Clinical NNP cord-010119-t1x9gknd 6735 10 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 6735 11 , , , cord-010119-t1x9gknd 6735 12 Raritan Raritan NNP cord-010119-t1x9gknd 6735 13 NJ NJ NNP cord-010119-t1x9gknd 6735 14 and and CC cord-010119-t1x9gknd 6735 15 Immucor Immucor NNP cord-010119-t1x9gknd 6735 16 , , , cord-010119-t1x9gknd 6735 17 Norcross Norcross NNP cord-010119-t1x9gknd 6735 18 GA GA NNP cord-010119-t1x9gknd 6735 19 ) ) -RRB- cord-010119-t1x9gknd 6735 20 per per IN cord-010119-t1x9gknd 6735 21 the the DT cord-010119-t1x9gknd 6735 22 manufacturer manufacturer NN cord-010119-t1x9gknd 6735 23 's 's POS cord-010119-t1x9gknd 6735 24 instructions instruction NNS cord-010119-t1x9gknd 6735 25 for for IN cord-010119-t1x9gknd 6735 26 specificities specificity NNS cord-010119-t1x9gknd 6735 27 from from IN cord-010119-t1x9gknd 6735 28 the the DT cord-010119-t1x9gknd 6735 29 Rh Rh NNP cord-010119-t1x9gknd 6735 30 , , , cord-010119-t1x9gknd 6735 31 Duffy Duffy NNP cord-010119-t1x9gknd 6735 32 , , , cord-010119-t1x9gknd 6735 33 Kidd Kidd NNP cord-010119-t1x9gknd 6735 34 and and CC cord-010119-t1x9gknd 6735 35 MNS MNS NNP cord-010119-t1x9gknd 6735 36 blood blood NN cord-010119-t1x9gknd 6735 37 groups group NNS cord-010119-t1x9gknd 6735 38 ( ( -LRB- cord-010119-t1x9gknd 6735 39 see see VB cord-010119-t1x9gknd 6735 40 Table Table NNP cord-010119-t1x9gknd 6735 41 _SP cord-010119-t1x9gknd 6735 42 1 1 CD cord-010119-t1x9gknd 6735 43 ) ) -RRB- cord-010119-t1x9gknd 6735 44 . . . cord-010119-t1x9gknd 6736 1 Patient patient JJ cord-010119-t1x9gknd 6736 2 source source NN cord-010119-t1x9gknd 6736 3 antibodies antibody NNS cord-010119-t1x9gknd 6736 4 ( ( -LRB- cord-010119-t1x9gknd 6736 5 anti anti JJ cord-010119-t1x9gknd 6736 6 - - JJ cord-010119-t1x9gknd 6736 7 D d JJ cord-010119-t1x9gknd 6736 8 , , , cord-010119-t1x9gknd 6736 9 anti anti JJ cord-010119-t1x9gknd 6736 10 - - NN cord-010119-t1x9gknd 6736 11 c c JJ cord-010119-t1x9gknd 6736 12 ) ) -RRB- cord-010119-t1x9gknd 6736 13 were be VBD cord-010119-t1x9gknd 6736 14 also also RB cord-010119-t1x9gknd 6736 15 tested test VBN cord-010119-t1x9gknd 6736 16 . . . cord-010119-t1x9gknd 6737 1 Testing testing NN cord-010119-t1x9gknd 6737 2 was be VBD cord-010119-t1x9gknd 6737 3 performed perform VBN cord-010119-t1x9gknd 6737 4 before before IN cord-010119-t1x9gknd 6737 5 DTT DTT NNP cord-010119-t1x9gknd 6737 6 treatment treatment NN cord-010119-t1x9gknd 6737 7 , , , cord-010119-t1x9gknd 6737 8 on on IN cord-010119-t1x9gknd 6737 9 the the DT cord-010119-t1x9gknd 6737 10 day day NN cord-010119-t1x9gknd 6737 11 of of IN cord-010119-t1x9gknd 6737 12 DTT DTT NNP cord-010119-t1x9gknd 6737 13 treatment treatment NN cord-010119-t1x9gknd 6737 14 and and CC cord-010119-t1x9gknd 6737 15 up up IN cord-010119-t1x9gknd 6737 16 to to TO cord-010119-t1x9gknd 6737 17 9 9 CD cord-010119-t1x9gknd 6737 18 days day NNS cord-010119-t1x9gknd 6737 19 following follow VBG cord-010119-t1x9gknd 6737 20 the the DT cord-010119-t1x9gknd 6737 21 DTT DTT NNP cord-010119-t1x9gknd 6737 22 treatment treatment NN cord-010119-t1x9gknd 6737 23 of of IN cord-010119-t1x9gknd 6737 24 RRBC RRBC NNP cord-010119-t1x9gknd 6737 25 . . . cord-010119-t1x9gknd 6738 1 Reactions reaction NNS cord-010119-t1x9gknd 6738 2 were be VBD cord-010119-t1x9gknd 6738 3 graded grade VBN cord-010119-t1x9gknd 6738 4 using use VBG cord-010119-t1x9gknd 6738 5 standard standard JJ cord-010119-t1x9gknd 6738 6 serological serological JJ cord-010119-t1x9gknd 6738 7 grading grading NN cord-010119-t1x9gknd 6738 8 of of IN cord-010119-t1x9gknd 6738 9 0 0 CD cord-010119-t1x9gknd 6738 10 ( ( -LRB- cord-010119-t1x9gknd 6738 11 negative negative JJ cord-010119-t1x9gknd 6738 12 ) ) -RRB- cord-010119-t1x9gknd 6738 13 to to IN cord-010119-t1x9gknd 6738 14 41 41 CD cord-010119-t1x9gknd 6738 15 ( ( -LRB- cord-010119-t1x9gknd 6738 16 positive positive JJ cord-010119-t1x9gknd 6738 17 ) ) -RRB- cord-010119-t1x9gknd 6738 18 reaction reaction NN cord-010119-t1x9gknd 6738 19 strength strength NN cord-010119-t1x9gknd 6738 20 . . . cord-010119-t1x9gknd 6739 1 Stored store VBN cord-010119-t1x9gknd 6739 2 DTT DTT NNP cord-010119-t1x9gknd 6739 3 - - HYPH cord-010119-t1x9gknd 6739 4 treated treat VBN cord-010119-t1x9gknd 6739 5 RRBC RRBC NNP cord-010119-t1x9gknd 6739 6 were be VBD cord-010119-t1x9gknd 6739 7 also also RB cord-010119-t1x9gknd 6739 8 observed observe VBN cord-010119-t1x9gknd 6739 9 for for IN cord-010119-t1x9gknd 6739 10 hemolysis hemolysis NN cord-010119-t1x9gknd 6739 11 during during IN cord-010119-t1x9gknd 6739 12 the the DT cord-010119-t1x9gknd 6739 13 storage storage NN cord-010119-t1x9gknd 6739 14 period period NN cord-010119-t1x9gknd 6739 15 . . . cord-010119-t1x9gknd 6740 1 Results result NNS cord-010119-t1x9gknd 6740 2 / / SYM cord-010119-t1x9gknd 6740 3 Findings finding NNS cord-010119-t1x9gknd 6740 4 : : : cord-010119-t1x9gknd 6741 1 See see VB cord-010119-t1x9gknd 6741 2 Table table NN cord-010119-t1x9gknd 6741 3 1 1 CD cord-010119-t1x9gknd 6741 4 for for IN cord-010119-t1x9gknd 6741 5 a a DT cord-010119-t1x9gknd 6741 6 summary summary NN cord-010119-t1x9gknd 6741 7 of of IN cord-010119-t1x9gknd 6741 8 results result NNS cord-010119-t1x9gknd 6741 9 . . . cord-010119-t1x9gknd 6742 1 Commercial commercial JJ cord-010119-t1x9gknd 6742 2 monoclonal monoclonal JJ cord-010119-t1x9gknd 6742 3 and and CC cord-010119-t1x9gknd 6742 4 human human JJ cord-010119-t1x9gknd 6742 5 source source NN cord-010119-t1x9gknd 6742 6 antisera antisera NN cord-010119-t1x9gknd 6742 7 , , , cord-010119-t1x9gknd 6742 8 and and CC cord-010119-t1x9gknd 6742 9 patient patient JJ cord-010119-t1x9gknd 6742 10 source source NN cord-010119-t1x9gknd 6742 11 antibody antibody NN cord-010119-t1x9gknd 6742 12 , , , cord-010119-t1x9gknd 6742 13 were be VBD cord-010119-t1x9gknd 6742 14 reactive reactive JJ cord-010119-t1x9gknd 6742 15 with with IN cord-010119-t1x9gknd 6742 16 the the DT cord-010119-t1x9gknd 6742 17 DTT DTT NNP cord-010119-t1x9gknd 6742 18 - - HYPH cord-010119-t1x9gknd 6742 19 treated treat VBN cord-010119-t1x9gknd 6742 20 RRBC RRBC NNP cord-010119-t1x9gknd 6742 21 throughout throughout IN cord-010119-t1x9gknd 6742 22 the the DT cord-010119-t1x9gknd 6742 23 storage storage NN cord-010119-t1x9gknd 6742 24 period period NN cord-010119-t1x9gknd 6742 25 . . . cord-010119-t1x9gknd 6743 1 Reactivity reactivity NN cord-010119-t1x9gknd 6743 2 decreased decrease VBD cord-010119-t1x9gknd 6743 3 by by IN cord-010119-t1x9gknd 6743 4 less less JJR cord-010119-t1x9gknd 6743 5 than than IN cord-010119-t1x9gknd 6743 6 one one CD cord-010119-t1x9gknd 6743 7 reaction reaction NN cord-010119-t1x9gknd 6743 8 grade grade NN cord-010119-t1x9gknd 6743 9 for for IN cord-010119-t1x9gknd 6743 10 all all DT cord-010119-t1x9gknd 6743 11 antisera antisera NN cord-010119-t1x9gknd 6743 12 and and CC cord-010119-t1x9gknd 6743 13 patient patient JJ cord-010119-t1x9gknd 6743 14 source source NN cord-010119-t1x9gknd 6743 15 antibodies antibody NNS cord-010119-t1x9gknd 6743 16 tested test VBN cord-010119-t1x9gknd 6743 17 . . . cord-010119-t1x9gknd 6744 1 Mild mild JJ cord-010119-t1x9gknd 6744 2 to to IN cord-010119-t1x9gknd 6744 3 moderate moderate JJ cord-010119-t1x9gknd 6744 4 hemolysis hemolysis NN cord-010119-t1x9gknd 6744 5 was be VBD cord-010119-t1x9gknd 6744 6 noted note VBN cord-010119-t1x9gknd 6744 7 in in IN cord-010119-t1x9gknd 6744 8 the the DT cord-010119-t1x9gknd 6744 9 DTTtreated dtttreate VBN cord-010119-t1x9gknd 6744 10 RRBC RRBC NNP cord-010119-t1x9gknd 6744 11 's be VBZ cord-010119-t1x9gknd 6744 12 during during IN cord-010119-t1x9gknd 6744 13 the the DT cord-010119-t1x9gknd 6744 14 storage storage NN cord-010119-t1x9gknd 6744 15 period period NN cord-010119-t1x9gknd 6744 16 . . . cord-010119-t1x9gknd 6745 1 Conclusion conclusion NN cord-010119-t1x9gknd 6745 2 : : : cord-010119-t1x9gknd 6745 3 DTT DTT NNP cord-010119-t1x9gknd 6745 4 - - HYPH cord-010119-t1x9gknd 6745 5 treated treat VBN cord-010119-t1x9gknd 6745 6 RRBC RRBC NNP cord-010119-t1x9gknd 6745 7 showed show VBD cord-010119-t1x9gknd 6745 8 adequate adequate JJ cord-010119-t1x9gknd 6745 9 reactivity reactivity NN cord-010119-t1x9gknd 6745 10 with with IN cord-010119-t1x9gknd 6745 11 various various JJ cord-010119-t1x9gknd 6745 12 red red JJ cord-010119-t1x9gknd 6745 13 cell cell NN cord-010119-t1x9gknd 6745 14 antisera antisera NN cord-010119-t1x9gknd 6745 15 after after IN cord-010119-t1x9gknd 6745 16 storage storage NN cord-010119-t1x9gknd 6745 17 for for IN cord-010119-t1x9gknd 6745 18 up up IN cord-010119-t1x9gknd 6745 19 to to TO cord-010119-t1x9gknd 6745 20 9 9 CD cord-010119-t1x9gknd 6745 21 days day NNS cord-010119-t1x9gknd 6745 22 . . . cord-010119-t1x9gknd 6746 1 This this DT cord-010119-t1x9gknd 6746 2 suggests suggest VBZ cord-010119-t1x9gknd 6746 3 that that IN cord-010119-t1x9gknd 6746 4 DTTtreated dtttreate VBN cord-010119-t1x9gknd 6746 5 reagent reagent JJ cord-010119-t1x9gknd 6746 6 red red JJ cord-010119-t1x9gknd 6746 7 cells cell NNS cord-010119-t1x9gknd 6746 8 can can MD cord-010119-t1x9gknd 6746 9 be be VB cord-010119-t1x9gknd 6746 10 stored store VBN cord-010119-t1x9gknd 6746 11 for for IN cord-010119-t1x9gknd 6746 12 at at RB cord-010119-t1x9gknd 6746 13 least least JJS cord-010119-t1x9gknd 6746 14 9 9 CD cord-010119-t1x9gknd 6746 15 days day NNS cord-010119-t1x9gknd 6746 16 and and CC cord-010119-t1x9gknd 6746 17 used use VBN cord-010119-t1x9gknd 6746 18 for for IN cord-010119-t1x9gknd 6746 19 the the DT cord-010119-t1x9gknd 6746 20 detection detection NN cord-010119-t1x9gknd 6746 21 of of IN cord-010119-t1x9gknd 6746 22 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6746 23 with with IN cord-010119-t1x9gknd 6746 24 minimal minimal JJ cord-010119-t1x9gknd 6746 25 effect effect NN cord-010119-t1x9gknd 6746 26 on on IN cord-010119-t1x9gknd 6746 27 detection detection NN cord-010119-t1x9gknd 6746 28 ability ability NN cord-010119-t1x9gknd 6746 29 . . . cord-010119-t1x9gknd 6747 1 Batch batch NN cord-010119-t1x9gknd 6747 2 preparation preparation NN cord-010119-t1x9gknd 6747 3 and and CC cord-010119-t1x9gknd 6747 4 storage storage NN cord-010119-t1x9gknd 6747 5 of of IN cord-010119-t1x9gknd 6747 6 DTT dtt NN cord-010119-t1x9gknd 6747 7 - - HYPH cord-010119-t1x9gknd 6747 8 treated treat VBN cord-010119-t1x9gknd 6747 9 RRBC RRBC NNP cord-010119-t1x9gknd 6747 10 can can MD cord-010119-t1x9gknd 6747 11 increase increase VB cord-010119-t1x9gknd 6747 12 testing test VBG cord-010119-t1x9gknd 6747 13 efficiency efficiency NN cord-010119-t1x9gknd 6747 14 and and CC cord-010119-t1x9gknd 6747 15 decrease decrease VB cord-010119-t1x9gknd 6747 16 turn turn NN cord-010119-t1x9gknd 6747 17 - - HYPH cord-010119-t1x9gknd 6747 18 around around IN cord-010119-t1x9gknd 6747 19 - - HYPH cord-010119-t1x9gknd 6747 20 time time NN cord-010119-t1x9gknd 6747 21 when when WRB cord-010119-t1x9gknd 6747 22 performing perform VBG cord-010119-t1x9gknd 6747 23 pre pre JJ cord-010119-t1x9gknd 6747 24 - - JJ cord-010119-t1x9gknd 6747 25 transfusion transfusion JJ cord-010119-t1x9gknd 6747 26 testing testing NN cord-010119-t1x9gknd 6747 27 for for IN cord-010119-t1x9gknd 6747 28 patients patient NNS cord-010119-t1x9gknd 6747 29 receiving receive VBG cord-010119-t1x9gknd 6747 30 anti anti JJ cord-010119-t1x9gknd 6747 31 - - JJ cord-010119-t1x9gknd 6747 32 CD38 cd38 JJ cord-010119-t1x9gknd 6747 33 therapy therapy NN cord-010119-t1x9gknd 6747 34 . . . cord-010119-t1x9gknd 6748 1 Interference interference NN cord-010119-t1x9gknd 6748 2 : : : cord-010119-t1x9gknd 6748 3 More More JJR cord-010119-t1x9gknd 6748 4 Than than IN cord-010119-t1x9gknd 6748 5 Just just RB cord-010119-t1x9gknd 6748 6 Kell Kell NNP cord-010119-t1x9gknd 6748 7 ? ? . cord-010119-t1x9gknd 6749 1 Marilyn Marilyn NNP cord-010119-t1x9gknd 6749 2 Stewart Stewart NNP cord-010119-t1x9gknd 6749 3 * * NFP cord-010119-t1x9gknd 6749 4 , , , cord-010119-t1x9gknd 6749 5 Angela Angela NNP cord-010119-t1x9gknd 6749 6 Treml Treml NNP cord-010119-t1x9gknd 6749 7 and and CC cord-010119-t1x9gknd 6749 8 Geoffrey Geoffrey NNP cord-010119-t1x9gknd 6749 9 Wool Wool NNP cord-010119-t1x9gknd 6749 10 . . . cord-010119-t1x9gknd 6750 1 University University NNP cord-010119-t1x9gknd 6750 2 of of IN cord-010119-t1x9gknd 6750 3 Chicago Chicago NNP cord-010119-t1x9gknd 6750 4 Background Background NNP cord-010119-t1x9gknd 6750 5 / / SYM cord-010119-t1x9gknd 6750 6 Case Case NNP cord-010119-t1x9gknd 6750 7 Studies Studies NNPS cord-010119-t1x9gknd 6750 8 : : : cord-010119-t1x9gknd 6750 9 Daratumumab Daratumumab NNP cord-010119-t1x9gknd 6750 10 ( ( -LRB- cord-010119-t1x9gknd 6750 11 DARA DARA NNP cord-010119-t1x9gknd 6750 12 ) ) -RRB- cord-010119-t1x9gknd 6750 13 is be VBZ cord-010119-t1x9gknd 6750 14 an an DT cord-010119-t1x9gknd 6750 15 anti anti JJ cord-010119-t1x9gknd 6750 16 - - JJ cord-010119-t1x9gknd 6750 17 myeloma myeloma JJ cord-010119-t1x9gknd 6750 18 and and CC cord-010119-t1x9gknd 6750 19 anti anti JJ cord-010119-t1x9gknd 6750 20 - - JJ cord-010119-t1x9gknd 6750 21 lymphoma lymphoma JJ cord-010119-t1x9gknd 6750 22 agent agent NN cord-010119-t1x9gknd 6750 23 that that WDT cord-010119-t1x9gknd 6750 24 is be VBZ cord-010119-t1x9gknd 6750 25 known know VBN cord-010119-t1x9gknd 6750 26 to to TO cord-010119-t1x9gknd 6750 27 interfere interfere VB cord-010119-t1x9gknd 6750 28 with with IN cord-010119-t1x9gknd 6750 29 routine routine JJ cord-010119-t1x9gknd 6750 30 Blood Blood NNP cord-010119-t1x9gknd 6750 31 Bank Bank NNP cord-010119-t1x9gknd 6750 32 antibody antibody NN cord-010119-t1x9gknd 6750 33 screening screening NN cord-010119-t1x9gknd 6750 34 tests test NNS cord-010119-t1x9gknd 6750 35 . . . cord-010119-t1x9gknd 6751 1 DARA DARA NNP cord-010119-t1x9gknd 6751 2 is be VBZ cord-010119-t1x9gknd 6751 3 an an DT cord-010119-t1x9gknd 6751 4 IgG IgG NNP cord-010119-t1x9gknd 6751 5 monoclonal monoclonal JJ cord-010119-t1x9gknd 6751 6 antibody antibody NN cord-010119-t1x9gknd 6751 7 that that WDT cord-010119-t1x9gknd 6751 8 binds bind VBZ cord-010119-t1x9gknd 6751 9 CD38 CD38 NNP cord-010119-t1x9gknd 6751 10 that that WDT cord-010119-t1x9gknd 6751 11 is be VBZ cord-010119-t1x9gknd 6751 12 present present JJ cord-010119-t1x9gknd 6751 13 on on IN cord-010119-t1x9gknd 6751 14 the the DT cord-010119-t1x9gknd 6751 15 red red JJ cord-010119-t1x9gknd 6751 16 cell cell NN cord-010119-t1x9gknd 6751 17 surface surface NN cord-010119-t1x9gknd 6751 18 . . . cord-010119-t1x9gknd 6752 1 At at IN cord-010119-t1x9gknd 6752 2 the the DT cord-010119-t1x9gknd 6752 3 University University NNP cord-010119-t1x9gknd 6752 4 Of of IN cord-010119-t1x9gknd 6752 5 Chicago Chicago NNP cord-010119-t1x9gknd 6752 6 Blood Blood NNP cord-010119-t1x9gknd 6752 7 Bank Bank NNP cord-010119-t1x9gknd 6752 8 , , , cord-010119-t1x9gknd 6752 9 we -PRON- PRP cord-010119-t1x9gknd 6752 10 have have VBP cord-010119-t1x9gknd 6752 11 seen see VBN cord-010119-t1x9gknd 6752 12 many many JJ cord-010119-t1x9gknd 6752 13 patients patient NNS cord-010119-t1x9gknd 6752 14 treated treat VBN cord-010119-t1x9gknd 6752 15 with with IN cord-010119-t1x9gknd 6752 16 DARA DARA NNP cord-010119-t1x9gknd 6752 17 and and CC cord-010119-t1x9gknd 6752 18 were be VBD cord-010119-t1x9gknd 6752 19 showing show VBG cord-010119-t1x9gknd 6752 20 this this DT cord-010119-t1x9gknd 6752 21 interfering interfere VBG cord-010119-t1x9gknd 6752 22 reactivity reactivity NN cord-010119-t1x9gknd 6752 23 . . . cord-010119-t1x9gknd 6753 1 It -PRON- PRP cord-010119-t1x9gknd 6753 2 has have VBZ cord-010119-t1x9gknd 6753 3 been be VBN cord-010119-t1x9gknd 6753 4 well well RB cord-010119-t1x9gknd 6753 5 described describe VBN cord-010119-t1x9gknd 6753 6 that that IN cord-010119-t1x9gknd 6753 7 CD38 CD38 NNP cord-010119-t1x9gknd 6753 8 is be VBZ cord-010119-t1x9gknd 6753 9 a a DT cord-010119-t1x9gknd 6753 10 disulfidelinked disulfidelinked JJ cord-010119-t1x9gknd 6753 11 molecule molecule NN cord-010119-t1x9gknd 6753 12 and and CC cord-010119-t1x9gknd 6753 13 its -PRON- PRP$ cord-010119-t1x9gknd 6753 14 immune immune JJ cord-010119-t1x9gknd 6753 15 epitopes epitope NNS cord-010119-t1x9gknd 6753 16 are be VBP cord-010119-t1x9gknd 6753 17 disrupted disrupt VBN cord-010119-t1x9gknd 6753 18 by by IN cord-010119-t1x9gknd 6753 19 reducing reduce VBG cord-010119-t1x9gknd 6753 20 agents agent NNS cord-010119-t1x9gknd 6753 21 such such JJ cord-010119-t1x9gknd 6753 22 as as IN cord-010119-t1x9gknd 6753 23 DTT DTT NNP cord-010119-t1x9gknd 6753 24 . . . cord-010119-t1x9gknd 6754 1 We -PRON- PRP cord-010119-t1x9gknd 6754 2 performed perform VBD cord-010119-t1x9gknd 6754 3 a a DT cord-010119-t1x9gknd 6754 4 validation validation NN cord-010119-t1x9gknd 6754 5 of of IN cord-010119-t1x9gknd 6754 6 DTT dtt NN cord-010119-t1x9gknd 6754 7 - - HYPH cord-010119-t1x9gknd 6754 8 treatment treatment NN cord-010119-t1x9gknd 6754 9 of of IN cord-010119-t1x9gknd 6754 10 reagent reagent JJ cord-010119-t1x9gknd 6754 11 RBC RBC NNP cord-010119-t1x9gknd 6754 12 to to TO cord-010119-t1x9gknd 6754 13 abrogate abrogate VB cord-010119-t1x9gknd 6754 14 DARA DARA NNP cord-010119-t1x9gknd 6754 15 interference interference NN cord-010119-t1x9gknd 6754 16 . . . cord-010119-t1x9gknd 6755 1 Study Study NNP cord-010119-t1x9gknd 6755 2 Design Design NNP cord-010119-t1x9gknd 6755 3 / / SYM cord-010119-t1x9gknd 6755 4 Methods method NNS cord-010119-t1x9gknd 6755 5 : : : cord-010119-t1x9gknd 6755 6 The the DT cord-010119-t1x9gknd 6755 7 validation validation NN cord-010119-t1x9gknd 6755 8 was be VBD cord-010119-t1x9gknd 6755 9 done do VBN cord-010119-t1x9gknd 6755 10 to to TO cord-010119-t1x9gknd 6755 11 prove prove VB cord-010119-t1x9gknd 6755 12 that that IN cord-010119-t1x9gknd 6755 13 DTT DTT NNP cord-010119-t1x9gknd 6755 14 treated treat VBD cord-010119-t1x9gknd 6755 15 red red JJ cord-010119-t1x9gknd 6755 16 cells cell NNS cord-010119-t1x9gknd 6755 17 could could MD cord-010119-t1x9gknd 6755 18 be be VB cord-010119-t1x9gknd 6755 19 used use VBN cord-010119-t1x9gknd 6755 20 to to TO cord-010119-t1x9gknd 6755 21 screen screen VB cord-010119-t1x9gknd 6755 22 patients patient NNS cord-010119-t1x9gknd 6755 23 receiving receive VBG cord-010119-t1x9gknd 6755 24 DARA DARA NNP cord-010119-t1x9gknd 6755 25 and and CC cord-010119-t1x9gknd 6755 26 still still RB cord-010119-t1x9gknd 6755 27 detect detect VB cord-010119-t1x9gknd 6755 28 clinically clinically RB cord-010119-t1x9gknd 6755 29 significant significant JJ cord-010119-t1x9gknd 6755 30 allo allo NN cord-010119-t1x9gknd 6755 31 - - HYPH cord-010119-t1x9gknd 6755 32 antibodies antibody NNS cord-010119-t1x9gknd 6755 33 . . . cord-010119-t1x9gknd 6756 1 Screening screening NN cord-010119-t1x9gknd 6756 2 cells cell NNS cord-010119-t1x9gknd 6756 3 and and CC cord-010119-t1x9gknd 6756 4 panel panel NN cord-010119-t1x9gknd 6756 5 cells cell NNS cord-010119-t1x9gknd 6756 6 selected select VBN cord-010119-t1x9gknd 6756 7 for for IN cord-010119-t1x9gknd 6756 8 DTT DTT NNP cord-010119-t1x9gknd 6756 9 treatment treatment NN cord-010119-t1x9gknd 6756 10 were be VBD cord-010119-t1x9gknd 6756 11 those those DT cord-010119-t1x9gknd 6756 12 RBC RBC NNP cord-010119-t1x9gknd 6756 13 homozygous homozygous JJ cord-010119-t1x9gknd 6756 14 for for IN cord-010119-t1x9gknd 6756 15 clinically clinically RB cord-010119-t1x9gknd 6756 16 significant significant JJ cord-010119-t1x9gknd 6756 17 antigens antigen NNS cord-010119-t1x9gknd 6756 18 , , , cord-010119-t1x9gknd 6756 19 therefore therefore RB cord-010119-t1x9gknd 6756 20 allowing allow VBG cord-010119-t1x9gknd 6756 21 rule rule NN cord-010119-t1x9gknd 6756 22 - - HYPH cord-010119-t1x9gknd 6756 23 outs out NNS cord-010119-t1x9gknd 6756 24 of of IN cord-010119-t1x9gknd 6756 25 clinically clinically RB cord-010119-t1x9gknd 6756 26 significant significant JJ cord-010119-t1x9gknd 6756 27 antibodies antibody NNS cord-010119-t1x9gknd 6756 28 in in IN cord-010119-t1x9gknd 6756 29 patient patient JJ cord-010119-t1x9gknd 6756 30 plasma plasma NN cord-010119-t1x9gknd 6756 31 . . . cord-010119-t1x9gknd 6757 1 Several several JJ cord-010119-t1x9gknd 6757 2 patients patient NNS cord-010119-t1x9gknd 6757 3 that that WDT cord-010119-t1x9gknd 6757 4 had have VBD cord-010119-t1x9gknd 6757 5 received receive VBN cord-010119-t1x9gknd 6757 6 the the DT cord-010119-t1x9gknd 6757 7 DARA DARA NNP cord-010119-t1x9gknd 6757 8 drug drug NN cord-010119-t1x9gknd 6757 9 protocol protocol NN cord-010119-t1x9gknd 6757 10 were be VBD cord-010119-t1x9gknd 6757 11 selected select VBN cord-010119-t1x9gknd 6757 12 for for IN cord-010119-t1x9gknd 6757 13 testing testing NN cord-010119-t1x9gknd 6757 14 as as RB cord-010119-t1x9gknd 6757 15 well well RB cord-010119-t1x9gknd 6757 16 as as IN cord-010119-t1x9gknd 6757 17 many many JJ cord-010119-t1x9gknd 6757 18 patients patient NNS cord-010119-t1x9gknd 6757 19 that that WDT cord-010119-t1x9gknd 6757 20 had have VBD cord-010119-t1x9gknd 6757 21 allo allo NN cord-010119-t1x9gknd 6757 22 - - HYPH cord-010119-t1x9gknd 6757 23 and and CC cord-010119-t1x9gknd 6757 24 auto auto NN cord-010119-t1x9gknd 6757 25 - - HYPH cord-010119-t1x9gknd 6757 26 antibodies antibody NNS cord-010119-t1x9gknd 6757 27 ( ( -LRB- cord-010119-t1x9gknd 6757 28 but but CC cord-010119-t1x9gknd 6757 29 not not RB cord-010119-t1x9gknd 6757 30 DARA DARA NNP cord-010119-t1x9gknd 6757 31 treatment treatment NN cord-010119-t1x9gknd 6757 32 ) ) -RRB- cord-010119-t1x9gknd 6757 33 . . . cord-010119-t1x9gknd 6758 1 Reagent reagent NN cord-010119-t1x9gknd 6758 2 screening screening NN cord-010119-t1x9gknd 6758 3 cells cell NNS cord-010119-t1x9gknd 6758 4 and and CC cord-010119-t1x9gknd 6758 5 panel panel NN cord-010119-t1x9gknd 6758 6 cells cell NNS cord-010119-t1x9gknd 6758 7 were be VBD cord-010119-t1x9gknd 6758 8 treated treat VBN cord-010119-t1x9gknd 6758 9 with with IN cord-010119-t1x9gknd 6758 10 0.2 0.2 CD cord-010119-t1x9gknd 6758 11 M M NNP cord-010119-t1x9gknd 6758 12 DTT DTT NNP cord-010119-t1x9gknd 6758 13 prepared prepare VBD cord-010119-t1x9gknd 6758 14 using use VBG cord-010119-t1x9gknd 6758 15 the the DT cord-010119-t1x9gknd 6758 16 SOP sop NN cord-010119-t1x9gknd 6758 17 from from IN cord-010119-t1x9gknd 6758 18 Judd Judd NNP cord-010119-t1x9gknd 6758 19 's 's POS cord-010119-t1x9gknd 6758 20 Methods Methods NNPS cord-010119-t1x9gknd 6758 21 in in IN cord-010119-t1x9gknd 6758 22 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 6758 23 and and CC cord-010119-t1x9gknd 6758 24 the the DT cord-010119-t1x9gknd 6758 25 AABB AABB NNP cord-010119-t1x9gknd 6758 26 Technical Technical NNP cord-010119-t1x9gknd 6758 27 Manual Manual NNP cord-010119-t1x9gknd 6758 28 . . . cord-010119-t1x9gknd 6759 1 The the DT cord-010119-t1x9gknd 6759 2 treated treat VBN cord-010119-t1x9gknd 6759 3 cells cell NNS cord-010119-t1x9gknd 6759 4 were be VBD cord-010119-t1x9gknd 6759 5 preserved preserve VBN cord-010119-t1x9gknd 6759 6 between between IN cord-010119-t1x9gknd 6759 7 testing test VBG cord-010119-t1x9gknd 6759 8 episodes episode NNS cord-010119-t1x9gknd 6759 9 using use VBG cord-010119-t1x9gknd 6759 10 Alsever Alsever NNP cord-010119-t1x9gknd 6759 11 's 's POS cord-010119-t1x9gknd 6759 12 solution solution NN cord-010119-t1x9gknd 6759 13 , , , cord-010119-t1x9gknd 6759 14 stored store VBN cord-010119-t1x9gknd 6759 15 at at IN cord-010119-t1x9gknd 6759 16 ABSTRACT abstract JJ cord-010119-t1x9gknd 6759 17 2 2 CD cord-010119-t1x9gknd 6759 18 - - HYPH cord-010119-t1x9gknd 6759 19 5C 5c CD cord-010119-t1x9gknd 6759 20 , , , cord-010119-t1x9gknd 6759 21 and and CC cord-010119-t1x9gknd 6759 22 observed observe VBD cord-010119-t1x9gknd 6759 23 for for IN cord-010119-t1x9gknd 6759 24 hemolysis hemolysis NN cord-010119-t1x9gknd 6759 25 ( ( -LRB- cord-010119-t1x9gknd 6759 26 none none NN cord-010119-t1x9gknd 6759 27 was be VBD cord-010119-t1x9gknd 6759 28 seen see VBN cord-010119-t1x9gknd 6759 29 ) ) -RRB- cord-010119-t1x9gknd 6759 30 for for IN cord-010119-t1x9gknd 6759 31 up up IN cord-010119-t1x9gknd 6759 32 to to TO cord-010119-t1x9gknd 6759 33 21 21 CD cord-010119-t1x9gknd 6759 34 days day NNS cord-010119-t1x9gknd 6759 35 . . . cord-010119-t1x9gknd 6760 1 All all DT cord-010119-t1x9gknd 6760 2 immunohematology immunohematology NN cord-010119-t1x9gknd 6760 3 testing testing NN cord-010119-t1x9gknd 6760 4 using use VBG cord-010119-t1x9gknd 6760 5 DTT DTT NNP cord-010119-t1x9gknd 6760 6 - - HYPH cord-010119-t1x9gknd 6760 7 treated treat VBN cord-010119-t1x9gknd 6760 8 cells cell NNS cord-010119-t1x9gknd 6760 9 was be VBD cord-010119-t1x9gknd 6760 10 performed perform VBN cord-010119-t1x9gknd 6760 11 using use VBG cord-010119-t1x9gknd 6760 12 gel gel NN cord-010119-t1x9gknd 6760 13 methodology methodology NN cord-010119-t1x9gknd 6760 14 . . . cord-010119-t1x9gknd 6761 1 Untreated untreated JJ cord-010119-t1x9gknd 6761 2 and and CC cord-010119-t1x9gknd 6761 3 DTT DTT NNP cord-010119-t1x9gknd 6761 4 treated treat VBD cord-010119-t1x9gknd 6761 5 cells cell NNS cord-010119-t1x9gknd 6761 6 were be VBD cord-010119-t1x9gknd 6761 7 tested test VBN cord-010119-t1x9gknd 6761 8 with with IN cord-010119-t1x9gknd 6761 9 anti anti NNP cord-010119-t1x9gknd 6761 10 k k NNP cord-010119-t1x9gknd 6761 11 before before IN cord-010119-t1x9gknd 6761 12 any any DT cord-010119-t1x9gknd 6761 13 patient patient NN cord-010119-t1x9gknd 6761 14 testing testing NN cord-010119-t1x9gknd 6761 15 was be VBD cord-010119-t1x9gknd 6761 16 done do VBN cord-010119-t1x9gknd 6761 17 . . . cord-010119-t1x9gknd 6762 1 The the DT cord-010119-t1x9gknd 6762 2 untreated untreated JJ cord-010119-t1x9gknd 6762 3 cells cell NNS cord-010119-t1x9gknd 6762 4 reacted react VBD cord-010119-t1x9gknd 6762 5 2 2 CD cord-010119-t1x9gknd 6762 6 - - SYM cord-010119-t1x9gknd 6762 7 41 41 CD cord-010119-t1x9gknd 6762 8 with with IN cord-010119-t1x9gknd 6762 9 the the DT cord-010119-t1x9gknd 6762 10 anti anti NNP cord-010119-t1x9gknd 6762 11 k k NNP cord-010119-t1x9gknd 6762 12 , , , cord-010119-t1x9gknd 6762 13 and and CC cord-010119-t1x9gknd 6762 14 the the DT cord-010119-t1x9gknd 6762 15 treated treat VBN cord-010119-t1x9gknd 6762 16 cells cell NNS cord-010119-t1x9gknd 6762 17 were be VBD cord-010119-t1x9gknd 6762 18 negative negative JJ cord-010119-t1x9gknd 6762 19 . . . cord-010119-t1x9gknd 6763 1 These these DT cord-010119-t1x9gknd 6763 2 controls control NNS cord-010119-t1x9gknd 6763 3 were be VBD cord-010119-t1x9gknd 6763 4 run run VBN cord-010119-t1x9gknd 6763 5 and and CC cord-010119-t1x9gknd 6763 6 tested test VBN cord-010119-t1x9gknd 6763 7 each each DT cord-010119-t1x9gknd 6763 8 time time NN cord-010119-t1x9gknd 6763 9 DTT DTT NNP cord-010119-t1x9gknd 6763 10 treatment treatment NN cord-010119-t1x9gknd 6763 11 was be VBD cord-010119-t1x9gknd 6763 12 done do VBN cord-010119-t1x9gknd 6763 13 . . . cord-010119-t1x9gknd 6764 1 Thirty thirty CD cord-010119-t1x9gknd 6764 2 eight eight CD cord-010119-t1x9gknd 6764 3 patient patient NN cord-010119-t1x9gknd 6764 4 samples sample NNS cord-010119-t1x9gknd 6764 5 , , , cord-010119-t1x9gknd 6764 6 including include VBG cord-010119-t1x9gknd 6764 7 six six CD cord-010119-t1x9gknd 6764 8 DARA DARA NNP cord-010119-t1x9gknd 6764 9 patient patient NN cord-010119-t1x9gknd 6764 10 samples sample NNS cord-010119-t1x9gknd 6764 11 were be VBD cord-010119-t1x9gknd 6764 12 tested test VBN cord-010119-t1x9gknd 6764 13 . . . cord-010119-t1x9gknd 6765 1 Results result NNS cord-010119-t1x9gknd 6765 2 / / SYM cord-010119-t1x9gknd 6765 3 Finding finding NN cord-010119-t1x9gknd 6765 4 : : : cord-010119-t1x9gknd 6766 1 Of of IN cord-010119-t1x9gknd 6766 2 the the DT cord-010119-t1x9gknd 6766 3 six six CD cord-010119-t1x9gknd 6766 4 patients patient NNS cord-010119-t1x9gknd 6766 5 who who WP cord-010119-t1x9gknd 6766 6 had have VBD cord-010119-t1x9gknd 6766 7 DARA DARA NNP cord-010119-t1x9gknd 6766 8 interference interference NN cord-010119-t1x9gknd 6766 9 in in IN cord-010119-t1x9gknd 6766 10 their -PRON- PRP$ cord-010119-t1x9gknd 6766 11 untreated untreated JJ cord-010119-t1x9gknd 6766 12 antibody antibody NN cord-010119-t1x9gknd 6766 13 screens screen NNS cord-010119-t1x9gknd 6766 14 , , , cord-010119-t1x9gknd 6766 15 all all DT cord-010119-t1x9gknd 6766 16 samples sample NNS cord-010119-t1x9gknd 6766 17 had have VBD cord-010119-t1x9gknd 6766 18 negative negative JJ cord-010119-t1x9gknd 6766 19 reactions reaction NNS cord-010119-t1x9gknd 6766 20 with with IN cord-010119-t1x9gknd 6766 21 the the DT cord-010119-t1x9gknd 6766 22 DTT DTT NNP cord-010119-t1x9gknd 6766 23 treated treat VBD cord-010119-t1x9gknd 6766 24 cells cell NNS cord-010119-t1x9gknd 6766 25 except except IN cord-010119-t1x9gknd 6766 26 one one CD cord-010119-t1x9gknd 6766 27 patient patient NN cord-010119-t1x9gknd 6766 28 , , , cord-010119-t1x9gknd 6766 29 which which WDT cord-010119-t1x9gknd 6766 30 had have VBD cord-010119-t1x9gknd 6766 31 weak weak JJ cord-010119-t1x9gknd 6766 32 reactions reaction NNS cord-010119-t1x9gknd 6766 33 in in IN cord-010119-t1x9gknd 6766 34 one one CD cord-010119-t1x9gknd 6766 35 cell cell NN cord-010119-t1x9gknd 6766 36 . . . cord-010119-t1x9gknd 6767 1 This this DT cord-010119-t1x9gknd 6767 2 specimen specimen NN cord-010119-t1x9gknd 6767 3 was be VBD cord-010119-t1x9gknd 6767 4 repeated repeat VBN cord-010119-t1x9gknd 6767 5 three three CD cord-010119-t1x9gknd 6767 6 times time NNS cord-010119-t1x9gknd 6767 7 and and CC cord-010119-t1x9gknd 6767 8 all all DT cord-010119-t1x9gknd 6767 9 repeats repeat NNS cord-010119-t1x9gknd 6767 10 had have VBD cord-010119-t1x9gknd 6767 11 weak weak JJ cord-010119-t1x9gknd 6767 12 positive positive JJ cord-010119-t1x9gknd 6767 13 reactions reaction NNS cord-010119-t1x9gknd 6767 14 in in IN cord-010119-t1x9gknd 6767 15 the the DT cord-010119-t1x9gknd 6767 16 same same JJ cord-010119-t1x9gknd 6767 17 cell cell NN cord-010119-t1x9gknd 6767 18 . . . cord-010119-t1x9gknd 6768 1 This this DT cord-010119-t1x9gknd 6768 2 sample sample NN cord-010119-t1x9gknd 6768 3 was be VBD cord-010119-t1x9gknd 6768 4 sent send VBN cord-010119-t1x9gknd 6768 5 to to IN cord-010119-t1x9gknd 6768 6 the the DT cord-010119-t1x9gknd 6768 7 ARC ARC NNP cord-010119-t1x9gknd 6768 8 reference reference NN cord-010119-t1x9gknd 6768 9 lab lab NN cord-010119-t1x9gknd 6768 10 for for IN cord-010119-t1x9gknd 6768 11 DTT DTT NNP cord-010119-t1x9gknd 6768 12 treatment treatment NN cord-010119-t1x9gknd 6768 13 and and CC cord-010119-t1x9gknd 6768 14 all all DT cord-010119-t1x9gknd 6768 15 clinically clinically RB cord-010119-t1x9gknd 6768 16 significant significant JJ cord-010119-t1x9gknd 6768 17 antibodies antibody NNS cord-010119-t1x9gknd 6768 18 were be VBD cord-010119-t1x9gknd 6768 19 ruled rule VBN cord-010119-t1x9gknd 6768 20 out out RP cord-010119-t1x9gknd 6768 21 . . . cord-010119-t1x9gknd 6769 1 Patients patient NNS cord-010119-t1x9gknd 6769 2 with with IN cord-010119-t1x9gknd 6769 3 allo allo NN cord-010119-t1x9gknd 6769 4 - - HYPH cord-010119-t1x9gknd 6769 5 antibodies antibody NNS cord-010119-t1x9gknd 6769 6 present present JJ cord-010119-t1x9gknd 6769 7 in in IN cord-010119-t1x9gknd 6769 8 their -PRON- PRP$ cord-010119-t1x9gknd 6769 9 plasma plasma NN cord-010119-t1x9gknd 6769 10 did do VBD cord-010119-t1x9gknd 6769 11 react react VB cord-010119-t1x9gknd 6769 12 with with IN cord-010119-t1x9gknd 6769 13 the the DT cord-010119-t1x9gknd 6769 14 DTT DTT NNP cord-010119-t1x9gknd 6769 15 treated treat VBD cord-010119-t1x9gknd 6769 16 cells cell NNS cord-010119-t1x9gknd 6769 17 as as IN cord-010119-t1x9gknd 6769 18 would would MD cord-010119-t1x9gknd 6769 19 be be VB cord-010119-t1x9gknd 6769 20 expected expect VBN cord-010119-t1x9gknd 6769 21 based base VBN cord-010119-t1x9gknd 6769 22 on on IN cord-010119-t1x9gknd 6769 23 the the DT cord-010119-t1x9gknd 6769 24 underlying underlie VBG cord-010119-t1x9gknd 6769 25 alloantibody alloantibody NN cord-010119-t1x9gknd 6769 26 , , , cord-010119-t1x9gknd 6769 27 with with IN cord-010119-t1x9gknd 6769 28 the the DT cord-010119-t1x9gknd 6769 29 exception exception NN cord-010119-t1x9gknd 6769 30 of of IN cord-010119-t1x9gknd 6769 31 newly newly RB cord-010119-t1x9gknd 6769 32 formed form VBN cord-010119-t1x9gknd 6769 33 anti anti JJ cord-010119-t1x9gknd 6769 34 - - JJ cord-010119-t1x9gknd 6769 35 E e JJ cord-010119-t1x9gknd 6769 36 antibodies antibody NNS cord-010119-t1x9gknd 6769 37 in in IN cord-010119-t1x9gknd 6769 38 4 4 CD cord-010119-t1x9gknd 6769 39 patients patient NNS cord-010119-t1x9gknd 6769 40 . . . cord-010119-t1x9gknd 6770 1 Plasma plasma NN cord-010119-t1x9gknd 6770 2 from from IN cord-010119-t1x9gknd 6770 3 these these DT cord-010119-t1x9gknd 6770 4 four four CD cord-010119-t1x9gknd 6770 5 patients patient NNS cord-010119-t1x9gknd 6770 6 with with IN cord-010119-t1x9gknd 6770 7 a a DT cord-010119-t1x9gknd 6770 8 nascent nascent JJ cord-010119-t1x9gknd 6770 9 anti anti JJ cord-010119-t1x9gknd 6770 10 -E -e JJ cord-010119-t1x9gknd 6770 11 all all DT cord-010119-t1x9gknd 6770 12 showed show VBD cord-010119-t1x9gknd 6770 13 no no DT cord-010119-t1x9gknd 6770 14 reactivity reactivity NN cord-010119-t1x9gknd 6770 15 with with IN cord-010119-t1x9gknd 6770 16 DTT DTT NNP cord-010119-t1x9gknd 6770 17 treated treat VBD cord-010119-t1x9gknd 6770 18 cells cell NNS cord-010119-t1x9gknd 6770 19 . . . cord-010119-t1x9gknd 6771 1 Plasma plasma NN cord-010119-t1x9gknd 6771 2 from from IN cord-010119-t1x9gknd 6771 3 fourteen fourteen CD cord-010119-t1x9gknd 6771 4 patients patient NNS cord-010119-t1x9gknd 6771 5 with with IN cord-010119-t1x9gknd 6771 6 a a DT cord-010119-t1x9gknd 6771 7 long long JJ cord-010119-t1x9gknd 6771 8 history history NN cord-010119-t1x9gknd 6771 9 of of IN cord-010119-t1x9gknd 6771 10 anti anti JJ cord-010119-t1x9gknd 6771 11 - - JJ cord-010119-t1x9gknd 6771 12 E e JJ cord-010119-t1x9gknd 6771 13 ( ( -LRB- cord-010119-t1x9gknd 6771 14 greater great JJR cord-010119-t1x9gknd 6771 15 than than IN cord-010119-t1x9gknd 6771 16 6 6 CD cord-010119-t1x9gknd 6771 17 months month NNS cord-010119-t1x9gknd 6771 18 ) ) -RRB- cord-010119-t1x9gknd 6771 19 did do VBD cord-010119-t1x9gknd 6771 20 react react VB cord-010119-t1x9gknd 6771 21 with with IN cord-010119-t1x9gknd 6771 22 the the DT cord-010119-t1x9gknd 6771 23 DTT DTT NNP cord-010119-t1x9gknd 6771 24 treated treat VBD cord-010119-t1x9gknd 6771 25 cells cell NNS cord-010119-t1x9gknd 6771 26 . . . cord-010119-t1x9gknd 6772 1 Conclusion conclusion NN cord-010119-t1x9gknd 6772 2 : : : cord-010119-t1x9gknd 6772 3 DTT DTT NNP cord-010119-t1x9gknd 6772 4 treatment treatment NN cord-010119-t1x9gknd 6772 5 eliminates eliminate VBZ cord-010119-t1x9gknd 6772 6 DARA DARA NNP cord-010119-t1x9gknd 6772 7 interference interference NN cord-010119-t1x9gknd 6772 8 as as IN cord-010119-t1x9gknd 6772 9 previously previously RB cord-010119-t1x9gknd 6772 10 described describe VBN cord-010119-t1x9gknd 6772 11 , , , cord-010119-t1x9gknd 6772 12 but but CC cord-010119-t1x9gknd 6772 13 also also RB cord-010119-t1x9gknd 6772 14 unexpectedly unexpectedly RB cord-010119-t1x9gknd 6772 15 lessens lessen VBZ cord-010119-t1x9gknd 6772 16 the the DT cord-010119-t1x9gknd 6772 17 ability ability NN cord-010119-t1x9gknd 6772 18 of of IN cord-010119-t1x9gknd 6772 19 treated treat VBN cord-010119-t1x9gknd 6772 20 cells cell NNS cord-010119-t1x9gknd 6772 21 to to TO cord-010119-t1x9gknd 6772 22 react react VB cord-010119-t1x9gknd 6772 23 with with IN cord-010119-t1x9gknd 6772 24 nascent nascent JJ cord-010119-t1x9gknd 6772 25 anti anti JJ cord-010119-t1x9gknd 6772 26 - - JJ cord-010119-t1x9gknd 6772 27 E. e. JJ cord-010119-t1x9gknd 6773 1 Because because IN cord-010119-t1x9gknd 6773 2 of of IN cord-010119-t1x9gknd 6773 3 the the DT cord-010119-t1x9gknd 6773 4 negative negative JJ cord-010119-t1x9gknd 6773 5 testing testing NN cord-010119-t1x9gknd 6773 6 with with IN cord-010119-t1x9gknd 6773 7 some some DT cord-010119-t1x9gknd 6773 8 of of IN cord-010119-t1x9gknd 6773 9 the the DT cord-010119-t1x9gknd 6773 10 alloanti alloanti NNP cord-010119-t1x9gknd 6773 11 E E NNP cord-010119-t1x9gknd 6773 12 antibodies antibody NNS cord-010119-t1x9gknd 6773 13 , , , cord-010119-t1x9gknd 6773 14 DARA DARA NNP cord-010119-t1x9gknd 6773 15 - - HYPH cord-010119-t1x9gknd 6773 16 treated treat VBN cord-010119-t1x9gknd 6773 17 patients patient NNS cord-010119-t1x9gknd 6773 18 at at IN cord-010119-t1x9gknd 6773 19 UCM UCM NNP cord-010119-t1x9gknd 6773 20 will will MD cord-010119-t1x9gknd 6773 21 be be VB cord-010119-t1x9gknd 6773 22 given give VBN cord-010119-t1x9gknd 6773 23 both both DT cord-010119-t1x9gknd 6773 24 Kell Kell NNP cord-010119-t1x9gknd 6773 25 and and CC cord-010119-t1x9gknd 6773 26 E e JJ cord-010119-t1x9gknd 6773 27 negative negative JJ cord-010119-t1x9gknd 6773 28 blood blood NN cord-010119-t1x9gknd 6773 29 if if IN cord-010119-t1x9gknd 6773 30 they -PRON- PRP cord-010119-t1x9gknd 6773 31 have have VBP cord-010119-t1x9gknd 6773 32 immunohematology immunohematology NN cord-010119-t1x9gknd 6773 33 testing testing NN cord-010119-t1x9gknd 6773 34 performed perform VBN cord-010119-t1x9gknd 6773 35 using use VBG cord-010119-t1x9gknd 6773 36 DTT DTT NNP cord-010119-t1x9gknd 6773 37 reagent reagent NN cord-010119-t1x9gknd 6773 38 cells cell NNS cord-010119-t1x9gknd 6773 39 . . . cord-010119-t1x9gknd 6774 1 Mahboubeh Mahboubeh NNP cord-010119-t1x9gknd 6774 2 Rahmani Rahmani NNP cord-010119-t1x9gknd 6774 3 * * NFP cord-010119-t1x9gknd 6774 4 1 1 CD cord-010119-t1x9gknd 6774 5 , , , cord-010119-t1x9gknd 6774 6 Monique Monique NNP cord-010119-t1x9gknd 6774 7 Scott Scott NNP cord-010119-t1x9gknd 6774 8 2 2 CD cord-010119-t1x9gknd 6774 9 , , , cord-010119-t1x9gknd 6774 10 Garcia Garcia NNP cord-010119-t1x9gknd 6774 11 Curtis Curtis NNP cord-010119-t1x9gknd 6774 12 2 2 CD cord-010119-t1x9gknd 6774 13 , , , cord-010119-t1x9gknd 6774 14 Ellice Ellice NNP cord-010119-t1x9gknd 6774 15 Wong Wong NNP cord-010119-t1x9gknd 6774 16 2 2 CD cord-010119-t1x9gknd 6774 17 , , , cord-010119-t1x9gknd 6774 18 Alexa Alexa NNP cord-010119-t1x9gknd 6774 19 J J NNP cord-010119-t1x9gknd 6774 20 Siddon Siddon NNP cord-010119-t1x9gknd 6774 21 1 1 CD cord-010119-t1x9gknd 6774 22 and and CC cord-010119-t1x9gknd 6774 23 Christopher Christopher NNP cord-010119-t1x9gknd 6774 24 A A NNP cord-010119-t1x9gknd 6774 25 Tormey Tormey NNP cord-010119-t1x9gknd 6774 26 1 1 CD cord-010119-t1x9gknd 6774 27 . . . cord-010119-t1x9gknd 6775 1 1 1 CD cord-010119-t1x9gknd 6775 2 Yale Yale NNP cord-010119-t1x9gknd 6775 3 - - HYPH cord-010119-t1x9gknd 6775 4 New New NNP cord-010119-t1x9gknd 6775 5 Haven Haven NNP cord-010119-t1x9gknd 6775 6 Hospital Hospital NNP cord-010119-t1x9gknd 6775 7 , , , cord-010119-t1x9gknd 6775 8 2 2 CD cord-010119-t1x9gknd 6775 9 VA VA NNP cord-010119-t1x9gknd 6775 10 Connecticut Connecticut NNP cord-010119-t1x9gknd 6775 11 Healthcare Healthcare NNP cord-010119-t1x9gknd 6775 12 Background Background NNP cord-010119-t1x9gknd 6775 13 / / SYM cord-010119-t1x9gknd 6775 14 Case Case NNP cord-010119-t1x9gknd 6775 15 Studies Studies NNPS cord-010119-t1x9gknd 6775 16 : : : cord-010119-t1x9gknd 6775 17 Benign benign JJ cord-010119-t1x9gknd 6775 18 ethnic ethnic JJ cord-010119-t1x9gknd 6775 19 neutropenia neutropenia NN cord-010119-t1x9gknd 6775 20 ( ( -LRB- cord-010119-t1x9gknd 6775 21 BEN BEN NNP cord-010119-t1x9gknd 6775 22 ) ) -RRB- cord-010119-t1x9gknd 6775 23 seen see VBN cord-010119-t1x9gknd 6775 24 in in IN cord-010119-t1x9gknd 6775 25 approximately approximately RB cord-010119-t1x9gknd 6775 26 25 25 CD cord-010119-t1x9gknd 6775 27 % % NN cord-010119-t1x9gknd 6775 28 to to TO cord-010119-t1x9gknd 6775 29 50 50 CD cord-010119-t1x9gknd 6775 30 % % NN cord-010119-t1x9gknd 6775 31 of of IN cord-010119-t1x9gknd 6775 32 persons person NNS cord-010119-t1x9gknd 6775 33 of of IN cord-010119-t1x9gknd 6775 34 African african JJ cord-010119-t1x9gknd 6775 35 descent descent NN cord-010119-t1x9gknd 6775 36 is be VBZ cord-010119-t1x9gknd 6775 37 characterized characterize VBN cord-010119-t1x9gknd 6775 38 by by IN cord-010119-t1x9gknd 6775 39 neutrophil neutrophil NN cord-010119-t1x9gknd 6775 40 count count NN cord-010119-t1x9gknd 6775 41 of of IN cord-010119-t1x9gknd 6775 42 < < NNP cord-010119-t1x9gknd 6775 43 1.5x10 1.5x10 CD cord-010119-t1x9gknd 6775 44 9 9 CD cord-010119-t1x9gknd 6775 45 /L /L . cord-010119-t1x9gknd 6775 46 with with IN cord-010119-t1x9gknd 6775 47 no no DT cord-010119-t1x9gknd 6775 48 obvious obvious JJ cord-010119-t1x9gknd 6775 49 cause cause NN cord-010119-t1x9gknd 6775 50 and and CC cord-010119-t1x9gknd 6775 51 no no DT cord-010119-t1x9gknd 6775 52 increased increase VBN cord-010119-t1x9gknd 6775 53 susceptibility susceptibility NN cord-010119-t1x9gknd 6775 54 to to IN cord-010119-t1x9gknd 6775 55 infection infection NN cord-010119-t1x9gknd 6775 56 or or CC cord-010119-t1x9gknd 6775 57 any any DT cord-010119-t1x9gknd 6775 58 other other JJ cord-010119-t1x9gknd 6775 59 adverse adverse JJ cord-010119-t1x9gknd 6775 60 effect effect NN cord-010119-t1x9gknd 6775 61 . . . cord-010119-t1x9gknd 6776 1 At at IN cord-010119-t1x9gknd 6776 2 present present JJ cord-010119-t1x9gknd 6776 3 , , , cord-010119-t1x9gknd 6776 4 there there EX cord-010119-t1x9gknd 6776 5 is be VBZ cord-010119-t1x9gknd 6776 6 no no DT cord-010119-t1x9gknd 6776 7 laboratory laboratory NN cord-010119-t1x9gknd 6776 8 assay assay NN cord-010119-t1x9gknd 6776 9 used use VBN cord-010119-t1x9gknd 6776 10 to to TO cord-010119-t1x9gknd 6776 11 identify identify VB cord-010119-t1x9gknd 6776 12 this this DT cord-010119-t1x9gknd 6776 13 condition condition NN cord-010119-t1x9gknd 6776 14 and and CC cord-010119-t1x9gknd 6776 15 it -PRON- PRP cord-010119-t1x9gknd 6776 16 is be VBZ cord-010119-t1x9gknd 6776 17 generally generally RB cord-010119-t1x9gknd 6776 18 diagnosed diagnose VBN cord-010119-t1x9gknd 6776 19 on on IN cord-010119-t1x9gknd 6776 20 a a DT cord-010119-t1x9gknd 6776 21 clinical clinical JJ cord-010119-t1x9gknd 6776 22 basis basis NN cord-010119-t1x9gknd 6776 23 . . . cord-010119-t1x9gknd 6777 1 In in IN cord-010119-t1x9gknd 6777 2 this this DT cord-010119-t1x9gknd 6777 3 study study NN cord-010119-t1x9gknd 6777 4 , , , cord-010119-t1x9gknd 6777 5 we -PRON- PRP cord-010119-t1x9gknd 6777 6 investigated investigate VBD cord-010119-t1x9gknd 6777 7 whether whether IN cord-010119-t1x9gknd 6777 8 Duffy Duffy NNP cord-010119-t1x9gknd 6777 9 ( ( -LRB- cord-010119-t1x9gknd 6777 10 Fy Fy NNP cord-010119-t1x9gknd 6777 11 ) ) -RRB- cord-010119-t1x9gknd 6777 12 blood blood NN cord-010119-t1x9gknd 6777 13 group group NN cord-010119-t1x9gknd 6777 14 phenotyping phenotyping NN cord-010119-t1x9gknd 6777 15 would would MD cord-010119-t1x9gknd 6777 16 be be VB cord-010119-t1x9gknd 6777 17 a a DT cord-010119-t1x9gknd 6777 18 potentially potentially RB cord-010119-t1x9gknd 6777 19 useful useful JJ cord-010119-t1x9gknd 6777 20 modality modality NN cord-010119-t1x9gknd 6777 21 to to TO cord-010119-t1x9gknd 6777 22 help help VB cord-010119-t1x9gknd 6777 23 identify identify VB cord-010119-t1x9gknd 6777 24 patients patient NNS cord-010119-t1x9gknd 6777 25 with with IN cord-010119-t1x9gknd 6777 26 BEN BEN NNP cord-010119-t1x9gknd 6777 27 ; ; : cord-010119-t1x9gknd 6777 28 such such JJ cord-010119-t1x9gknd 6777 29 testing testing NN cord-010119-t1x9gknd 6777 30 could could MD cord-010119-t1x9gknd 6777 31 potentially potentially RB cord-010119-t1x9gknd 6777 32 be be VB cord-010119-t1x9gknd 6777 33 used use VBN cord-010119-t1x9gknd 6777 34 as as IN cord-010119-t1x9gknd 6777 35 a a DT cord-010119-t1x9gknd 6777 36 surrogate surrogate JJ cord-010119-t1x9gknd 6777 37 test test NN cord-010119-t1x9gknd 6777 38 to to TO cord-010119-t1x9gknd 6777 39 prevent prevent VB cord-010119-t1x9gknd 6777 40 unnecessary unnecessary JJ cord-010119-t1x9gknd 6777 41 further further JJ cord-010119-t1x9gknd 6777 42 work work NN cord-010119-t1x9gknd 6777 43 up up RP cord-010119-t1x9gknd 6777 44 including include VBG cord-010119-t1x9gknd 6777 45 bone bone NN cord-010119-t1x9gknd 6777 46 marrow marrow NN cord-010119-t1x9gknd 6777 47 biopsy biopsy NN cord-010119-t1x9gknd 6777 48 in in IN cord-010119-t1x9gknd 6777 49 the the DT cord-010119-t1x9gknd 6777 50 correct correct JJ cord-010119-t1x9gknd 6777 51 ethnic ethnic JJ cord-010119-t1x9gknd 6777 52 and and CC cord-010119-t1x9gknd 6777 53 clinical clinical JJ cord-010119-t1x9gknd 6777 54 setting setting NN cord-010119-t1x9gknd 6777 55 . . . cord-010119-t1x9gknd 6778 1 Study Study NNP cord-010119-t1x9gknd 6778 2 Design Design NNP cord-010119-t1x9gknd 6778 3 / / SYM cord-010119-t1x9gknd 6778 4 Method method NN cord-010119-t1x9gknd 6778 5 : : : cord-010119-t1x9gknd 6779 1 Cases case NNS cord-010119-t1x9gknd 6779 2 included include VBD cord-010119-t1x9gknd 6779 3 patients patient NNS cord-010119-t1x9gknd 6779 4 clinically clinically RB cord-010119-t1x9gknd 6779 5 diagnosed diagnose VBN cord-010119-t1x9gknd 6779 6 with with IN cord-010119-t1x9gknd 6779 7 BEN BEN NNP cord-010119-t1x9gknd 6779 8 ; ; : cord-010119-t1x9gknd 6779 9 and and CC cord-010119-t1x9gknd 6779 10 controls control NNS cord-010119-t1x9gknd 6779 11 were be VBD cord-010119-t1x9gknd 6779 12 chosen choose VBN cord-010119-t1x9gknd 6779 13 randomly randomly RB cord-010119-t1x9gknd 6779 14 from from IN cord-010119-t1x9gknd 6779 15 the the DT cord-010119-t1x9gknd 6779 16 pools pool NNS cord-010119-t1x9gknd 6779 17 of of IN cord-010119-t1x9gknd 6779 18 patients patient NNS cord-010119-t1x9gknd 6779 19 from from IN cord-010119-t1x9gknd 6779 20 whom whom WP cord-010119-t1x9gknd 6779 21 a a DT cord-010119-t1x9gknd 6779 22 CBC CBC NNP cord-010119-t1x9gknd 6779 23 and and CC cord-010119-t1x9gknd 6779 24 type type NN cord-010119-t1x9gknd 6779 25 and and CC cord-010119-t1x9gknd 6779 26 screen screen NN cord-010119-t1x9gknd 6779 27 were be VBD cord-010119-t1x9gknd 6779 28 checked check VBN cord-010119-t1x9gknd 6779 29 for for IN cord-010119-t1x9gknd 6779 30 any any DT cord-010119-t1x9gknd 6779 31 other other JJ cord-010119-t1x9gknd 6779 32 reason reason NN cord-010119-t1x9gknd 6779 33 . . . cord-010119-t1x9gknd 6780 1 Cases case NNS cord-010119-t1x9gknd 6780 2 and and CC cord-010119-t1x9gknd 6780 3 controls control NNS cord-010119-t1x9gknd 6780 4 were be VBD cord-010119-t1x9gknd 6780 5 tested test VBN cord-010119-t1x9gknd 6780 6 for for IN cord-010119-t1x9gknd 6780 7 the the DT cord-010119-t1x9gknd 6780 8 RBC RBC NNP cord-010119-t1x9gknd 6780 9 antigens antigen NNS cord-010119-t1x9gknd 6780 10 Fy Fy NNP cord-010119-t1x9gknd 6780 11 a a NNP cord-010119-t1x9gknd 6780 12 and and CC cord-010119-t1x9gknd 6780 13 Fy Fy NNP cord-010119-t1x9gknd 6780 14 b b NNP cord-010119-t1x9gknd 6780 15 phenotype phenotype NN cord-010119-t1x9gknd 6780 16 using use VBG cord-010119-t1x9gknd 6780 17 serologic serologic JJ cord-010119-t1x9gknd 6780 18 methods method NNS cord-010119-t1x9gknd 6780 19 . . . cord-010119-t1x9gknd 6781 1 The the DT cord-010119-t1x9gknd 6781 2 Fy Fy NNP cord-010119-t1x9gknd 6781 3 phenotype phenotype NN cord-010119-t1x9gknd 6781 4 , , , cord-010119-t1x9gknd 6781 5 absolute absolute JJ cord-010119-t1x9gknd 6781 6 neutrophil neutrophil NN cord-010119-t1x9gknd 6781 7 count count NN cord-010119-t1x9gknd 6781 8 ( ( -LRB- cord-010119-t1x9gknd 6781 9 ANC ANC NNP cord-010119-t1x9gknd 6781 10 ) ) -RRB- cord-010119-t1x9gknd 6781 11 , , , cord-010119-t1x9gknd 6781 12 white white JJ cord-010119-t1x9gknd 6781 13 blood blood NN cord-010119-t1x9gknd 6781 14 cell cell NN cord-010119-t1x9gknd 6781 15 ( ( -LRB- cord-010119-t1x9gknd 6781 16 WBC WBC NNP cord-010119-t1x9gknd 6781 17 ) ) -RRB- cord-010119-t1x9gknd 6781 18 , , , cord-010119-t1x9gknd 6781 19 hemoglobin hemoglobin NN cord-010119-t1x9gknd 6781 20 level level NN cord-010119-t1x9gknd 6781 21 , , , cord-010119-t1x9gknd 6781 22 platelet platelet NN cord-010119-t1x9gknd 6781 23 count count NN cord-010119-t1x9gknd 6781 24 , , , cord-010119-t1x9gknd 6781 25 and and CC cord-010119-t1x9gknd 6781 26 medical medical JJ cord-010119-t1x9gknd 6781 27 diagnoses diagnosis NNS cord-010119-t1x9gknd 6781 28 were be VBD cord-010119-t1x9gknd 6781 29 extracted extract VBN cord-010119-t1x9gknd 6781 30 from from IN cord-010119-t1x9gknd 6781 31 the the DT cord-010119-t1x9gknd 6781 32 medical medical JJ cord-010119-t1x9gknd 6781 33 record record NN cord-010119-t1x9gknd 6781 34 . . . cord-010119-t1x9gknd 6782 1 Where where WRB cord-010119-t1x9gknd 6782 2 appropriate appropriate JJ cord-010119-t1x9gknd 6782 3 , , , cord-010119-t1x9gknd 6782 4 data datum NNS cord-010119-t1x9gknd 6782 5 were be VBD cord-010119-t1x9gknd 6782 6 compared compare VBN cord-010119-t1x9gknd 6782 7 statistically statistically RB cord-010119-t1x9gknd 6782 8 using use VBG cord-010119-t1x9gknd 6782 9 the the DT cord-010119-t1x9gknd 6782 10 Mann Mann NNP cord-010119-t1x9gknd 6782 11 - - HYPH cord-010119-t1x9gknd 6782 12 Whitney Whitney NNP cord-010119-t1x9gknd 6782 13 U U NNP cord-010119-t1x9gknd 6782 14 Test test VBP cord-010119-t1x9gknd 6782 15 with with IN cord-010119-t1x9gknd 6782 16 significance significance NN cord-010119-t1x9gknd 6782 17 set set VBN cord-010119-t1x9gknd 6782 18 at at IN cord-010119-t1x9gknd 6782 19 P<0.05 P<0.05 NNS cord-010119-t1x9gknd 6782 20 . . . cord-010119-t1x9gknd 6783 1 Results/ Results/ . cord-010119-t1x9gknd 6784 1 Finding finding NN cord-010119-t1x9gknd 6784 2 : : : cord-010119-t1x9gknd 6785 1 Subjects subject NNS cord-010119-t1x9gknd 6785 2 who who WP cord-010119-t1x9gknd 6785 3 were be VBD cord-010119-t1x9gknd 6785 4 clinically clinically RB cord-010119-t1x9gknd 6785 5 identified identify VBN cord-010119-t1x9gknd 6785 6 as as IN cord-010119-t1x9gknd 6785 7 having have VBG cord-010119-t1x9gknd 6785 8 probable probable JJ cord-010119-t1x9gknd 6785 9 BEN BEN NNP cord-010119-t1x9gknd 6785 10 included include VBD cord-010119-t1x9gknd 6785 11 7 7 CD cord-010119-t1x9gknd 6785 12 patients patient NNS cord-010119-t1x9gknd 6785 13 ( ( -LRB- cord-010119-t1x9gknd 6785 14 mean mean VB cord-010119-t1x9gknd 6785 15 age age NN cord-010119-t1x9gknd 6785 16 48.7 48.7 CD cord-010119-t1x9gknd 6786 1 ; ; : cord-010119-t1x9gknd 6786 2 all all DT cord-010119-t1x9gknd 6786 3 self self NN cord-010119-t1x9gknd 6786 4 - - HYPH cord-010119-t1x9gknd 6786 5 identified identify VBN cord-010119-t1x9gknd 6786 6 as as IN cord-010119-t1x9gknd 6786 7 African african JJ cord-010119-t1x9gknd 6786 8 - - HYPH cord-010119-t1x9gknd 6786 9 American american JJ cord-010119-t1x9gknd 6786 10 ; ; : cord-010119-t1x9gknd 6786 11 6/7 6/7 CD cord-010119-t1x9gknd 6786 12 were be VBD cord-010119-t1x9gknd 6786 13 male male JJ cord-010119-t1x9gknd 6786 14 ) ) -RRB- cord-010119-t1x9gknd 6786 15 and and CC cord-010119-t1x9gknd 6786 16 controls control NNS cord-010119-t1x9gknd 6786 17 included include VBD cord-010119-t1x9gknd 6786 18 50 50 CD cord-010119-t1x9gknd 6786 19 patients patient NNS cord-010119-t1x9gknd 6786 20 ( ( -LRB- cord-010119-t1x9gknd 6786 21 mean mean VB cord-010119-t1x9gknd 6786 22 age age NN cord-010119-t1x9gknd 6786 23 68.5 68.5 CD cord-010119-t1x9gknd 6786 24 ; ; : cord-010119-t1x9gknd 6786 25 10 10 CD cord-010119-t1x9gknd 6786 26 self self NN cord-010119-t1x9gknd 6786 27 - - HYPH cord-010119-t1x9gknd 6786 28 identified identify VBN cord-010119-t1x9gknd 6786 29 as as IN cord-010119-t1x9gknd 6786 30 African african JJ cord-010119-t1x9gknd 6786 31 American American NNP cord-010119-t1x9gknd 6786 32 ; ; : cord-010119-t1x9gknd 6786 33 ( ( -LRB- cord-010119-t1x9gknd 6786 34 50/50 50/50 CD cord-010119-t1x9gknd 6786 35 male male NN cord-010119-t1x9gknd 6786 36 ) ) -RRB- cord-010119-t1x9gknd 6786 37 . . . cord-010119-t1x9gknd 6787 1 All all DT cord-010119-t1x9gknd 6787 2 of of IN cord-010119-t1x9gknd 6787 3 the the DT cord-010119-t1x9gknd 6787 4 cases case NNS cord-010119-t1x9gknd 6787 5 ( ( -LRB- cord-010119-t1x9gknd 6787 6 100 100 CD cord-010119-t1x9gknd 6787 7 % % NN cord-010119-t1x9gknd 6787 8 ) ) -RRB- cord-010119-t1x9gknd 6787 9 diagnosed diagnose VBN cord-010119-t1x9gknd 6787 10 with with IN cord-010119-t1x9gknd 6787 11 BEN BEN NNP cord-010119-t1x9gknd 6787 12 had have VBD cord-010119-t1x9gknd 6787 13 Fy(a Fy(a NNP cord-010119-t1x9gknd 6787 14 - - HYPH cord-010119-t1x9gknd 6787 15 b- b- NNP cord-010119-t1x9gknd 6787 16 ) ) -RRB- cord-010119-t1x9gknd 6787 17 phenotype phenotype NN cord-010119-t1x9gknd 6787 18 . . . cord-010119-t1x9gknd 6788 1 Mean mean JJ cord-010119-t1x9gknd 6788 2 ANC ANC NNP cord-010119-t1x9gknd 6788 3 ( ( -LRB- cord-010119-t1x9gknd 6788 4 1.95x10 1.95x10 CD cord-010119-t1x9gknd 6788 5 3 3 CD cord-010119-t1x9gknd 6788 6 /uL /uL . cord-010119-t1x9gknd 6788 7 ) ) -RRB- cord-010119-t1x9gknd 6788 8 and and CC cord-010119-t1x9gknd 6788 9 WBC WBC NNP cord-010119-t1x9gknd 6788 10 counts count VBZ cord-010119-t1x9gknd 6788 11 ( ( -LRB- cord-010119-t1x9gknd 6788 12 4.04x10 4.04x10 CD cord-010119-t1x9gknd 6788 13 3 3 CD cord-010119-t1x9gknd 6788 14 /uL /uL . cord-010119-t1x9gknd 6788 15 ) ) -RRB- cord-010119-t1x9gknd 6788 16 were be VBD cord-010119-t1x9gknd 6788 17 significantly significantly RB cord-010119-t1x9gknd 6788 18 lower low JJR cord-010119-t1x9gknd 6788 19 in in IN cord-010119-t1x9gknd 6788 20 the the DT cord-010119-t1x9gknd 6788 21 cases case NNS cord-010119-t1x9gknd 6788 22 with with IN cord-010119-t1x9gknd 6788 23 BEN BEN NNP cord-010119-t1x9gknd 6788 24 and and CC cord-010119-t1x9gknd 6788 25 Fy(a Fy(a NNP cord-010119-t1x9gknd 6788 26 - - HYPH cord-010119-t1x9gknd 6788 27 b- b- NNP cord-010119-t1x9gknd 6788 28 ) ) -RRB- cord-010119-t1x9gknd 6788 29 phenotype phenotype NN cord-010119-t1x9gknd 6788 30 ( ( -LRB- cord-010119-t1x9gknd 6788 31 P50.0008 p50.0008 NN cord-010119-t1x9gknd 6788 32 and and CC cord-010119-t1x9gknd 6788 33 0.001 0.001 CD cord-010119-t1x9gknd 6788 34 , , , cord-010119-t1x9gknd 6788 35 respectively respectively RB cord-010119-t1x9gknd 6788 36 ) ) -RRB- cord-010119-t1x9gknd 6788 37 compared compare VBN cord-010119-t1x9gknd 6788 38 with with IN cord-010119-t1x9gknd 6788 39 controls control NNS cord-010119-t1x9gknd 6788 40 ( ( -LRB- cord-010119-t1x9gknd 6788 41 mean mean VB cord-010119-t1x9gknd 6788 42 ANC ANC NNP cord-010119-t1x9gknd 6788 43 5 5 CD cord-010119-t1x9gknd 6788 44 5.46x10 5.46x10 CD cord-010119-t1x9gknd 6788 45 3 3 CD cord-010119-t1x9gknd 6788 46 /uL /uL . cord-010119-t1x9gknd 6788 47 ; ; : cord-010119-t1x9gknd 6788 48 mean mean VB cord-010119-t1x9gknd 6788 49 WBC WBC NNP cord-010119-t1x9gknd 6788 50 count count NN cord-010119-t1x9gknd 6788 51 5 5 CD cord-010119-t1x9gknd 6788 52 8.14x10 8.14x10 CD cord-010119-t1x9gknd 6788 53 3 3 CD cord-010119-t1x9gknd 6788 54 /uL /uL . cord-010119-t1x9gknd 6788 55 ) ) -RRB- cord-010119-t1x9gknd 6788 56 . . . cord-010119-t1x9gknd 6789 1 There there EX cord-010119-t1x9gknd 6789 2 was be VBD cord-010119-t1x9gknd 6789 3 no no DT cord-010119-t1x9gknd 6789 4 significant significant JJ cord-010119-t1x9gknd 6789 5 difference difference NN cord-010119-t1x9gknd 6789 6 in in IN cord-010119-t1x9gknd 6789 7 mean mean JJ cord-010119-t1x9gknd 6789 8 platelet platelet NN cord-010119-t1x9gknd 6789 9 counts count NNS cord-010119-t1x9gknd 6789 10 ( ( -LRB- cord-010119-t1x9gknd 6789 11 161x10 161x10 CD cord-010119-t1x9gknd 6789 12 3 3 CD cord-010119-t1x9gknd 6789 13 /uL /uL . cord-010119-t1x9gknd 6790 1 vs vs IN cord-010119-t1x9gknd 6790 2 213x10 213x10 CD cord-010119-t1x9gknd 6790 3 3 3 CD cord-010119-t1x9gknd 6790 4 /uL /uL . cord-010119-t1x9gknd 6790 5 ; ; : cord-010119-t1x9gknd 6790 6 P50.2301 p50.2301 NN cord-010119-t1x9gknd 6790 7 ) ) -RRB- cord-010119-t1x9gknd 6790 8 or or CC cord-010119-t1x9gknd 6790 9 mean mean VB cord-010119-t1x9gknd 6790 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 6790 11 levels level NNS cord-010119-t1x9gknd 6790 12 ( ( -LRB- cord-010119-t1x9gknd 6790 13 12.4 12.4 CD cord-010119-t1x9gknd 6790 14 g g NN cord-010119-t1x9gknd 6790 15 / / SYM cord-010119-t1x9gknd 6790 16 dL dl NN cord-010119-t1x9gknd 6790 17 vs vs IN cord-010119-t1x9gknd 6790 18 11.7 11.7 CD cord-010119-t1x9gknd 6790 19 g g NN cord-010119-t1x9gknd 6790 20 / / SYM cord-010119-t1x9gknd 6790 21 dL dl NN cord-010119-t1x9gknd 6790 22 ; ; : cord-010119-t1x9gknd 6791 1 P50.6031 P50.6031 NNP cord-010119-t1x9gknd 6791 2 ) ) -RRB- cord-010119-t1x9gknd 6791 3 between between IN cord-010119-t1x9gknd 6791 4 the the DT cord-010119-t1x9gknd 6791 5 two two CD cord-010119-t1x9gknd 6791 6 groups group NNS cord-010119-t1x9gknd 6791 7 . . . cord-010119-t1x9gknd 6792 1 None none NN cord-010119-t1x9gknd 6792 2 of of IN cord-010119-t1x9gknd 6792 3 the the DT cord-010119-t1x9gknd 6792 4 patients patient NNS cord-010119-t1x9gknd 6792 5 with with IN cord-010119-t1x9gknd 6792 6 BEN BEN NNP cord-010119-t1x9gknd 6792 7 had have VBD cord-010119-t1x9gknd 6792 8 an an DT cord-010119-t1x9gknd 6792 9 accompanying accompany VBG cord-010119-t1x9gknd 6792 10 marrow marrow NN cord-010119-t1x9gknd 6792 11 - - HYPH cord-010119-t1x9gknd 6792 12 suppressive suppressive JJ cord-010119-t1x9gknd 6792 13 hematologic hematologic JJ cord-010119-t1x9gknd 6792 14 disorder disorder NN cord-010119-t1x9gknd 6792 15 based base VBN cord-010119-t1x9gknd 6792 16 on on IN cord-010119-t1x9gknd 6792 17 record record NN cord-010119-t1x9gknd 6792 18 review review NN cord-010119-t1x9gknd 6792 19 ; ; : cord-010119-t1x9gknd 6792 20 however however RB cord-010119-t1x9gknd 6792 21 , , , cord-010119-t1x9gknd 6792 22 18 18 CD cord-010119-t1x9gknd 6792 23 subjects subject NNS cord-010119-t1x9gknd 6792 24 in in IN cord-010119-t1x9gknd 6792 25 the the DT cord-010119-t1x9gknd 6792 26 control control NN cord-010119-t1x9gknd 6792 27 group group NN cord-010119-t1x9gknd 6792 28 had have VBD cord-010119-t1x9gknd 6792 29 accompanying accompany VBG cord-010119-t1x9gknd 6792 30 conditions condition NNS cord-010119-t1x9gknd 6792 31 that that WDT cord-010119-t1x9gknd 6792 32 were be VBD cord-010119-t1x9gknd 6792 33 potentially potentially RB cord-010119-t1x9gknd 6792 34 marrow marrow NN cord-010119-t1x9gknd 6792 35 - - HYPH cord-010119-t1x9gknd 6792 36 suppressive suppressive JJ cord-010119-t1x9gknd 6792 37 including include VBG cord-010119-t1x9gknd 6792 38 hepatocellular hepatocellular JJ cord-010119-t1x9gknd 6792 39 carcinoma carcinoma NN cord-010119-t1x9gknd 6792 40 , , , cord-010119-t1x9gknd 6792 41 acute acute JJ cord-010119-t1x9gknd 6792 42 myeloid myeloid NN cord-010119-t1x9gknd 6792 43 leukemia leukemia NN cord-010119-t1x9gknd 6792 44 , , , cord-010119-t1x9gknd 6792 45 and and CC cord-010119-t1x9gknd 6792 46 myelodysplastic myelodysplastic JJ cord-010119-t1x9gknd 6792 47 syndrome syndrome NN cord-010119-t1x9gknd 6792 48 . . . cord-010119-t1x9gknd 6793 1 Conclusion conclusion NN cord-010119-t1x9gknd 6793 2 : : : cord-010119-t1x9gknd 6793 3 Testing test VBG cord-010119-t1x9gknd 6793 4 for for IN cord-010119-t1x9gknd 6793 5 Fy Fy NNP cord-010119-t1x9gknd 6793 6 phenotype phenotype NN cord-010119-t1x9gknd 6793 7 could could MD cord-010119-t1x9gknd 6793 8 potentially potentially RB cord-010119-t1x9gknd 6793 9 be be VB cord-010119-t1x9gknd 6793 10 used use VBN cord-010119-t1x9gknd 6793 11 as as IN cord-010119-t1x9gknd 6793 12 a a DT cord-010119-t1x9gknd 6793 13 surrogate surrogate JJ cord-010119-t1x9gknd 6793 14 test test NN cord-010119-t1x9gknd 6793 15 in in IN cord-010119-t1x9gknd 6793 16 patients patient NNS cord-010119-t1x9gknd 6793 17 with with IN cord-010119-t1x9gknd 6793 18 chronic chronic JJ cord-010119-t1x9gknd 6793 19 neutropenia neutropenia NN cord-010119-t1x9gknd 6793 20 in in IN cord-010119-t1x9gknd 6793 21 a a DT cord-010119-t1x9gknd 6793 22 correct correct JJ cord-010119-t1x9gknd 6793 23 ethnic ethnic JJ cord-010119-t1x9gknd 6793 24 and and CC cord-010119-t1x9gknd 6793 25 clinical clinical JJ cord-010119-t1x9gknd 6793 26 setting setting NN cord-010119-t1x9gknd 6793 27 for for IN cord-010119-t1x9gknd 6793 28 the the DT cord-010119-t1x9gknd 6793 29 diagnosis diagnosis NN cord-010119-t1x9gknd 6793 30 of of IN cord-010119-t1x9gknd 6793 31 BEN BEN NNP cord-010119-t1x9gknd 6793 32 . . . cord-010119-t1x9gknd 6794 1 Further further JJ cord-010119-t1x9gknd 6794 2 studies study NNS cord-010119-t1x9gknd 6794 3 regarding regard VBG cord-010119-t1x9gknd 6794 4 Fy Fy NNP cord-010119-t1x9gknd 6794 5 phenotyping phenotyping NN cord-010119-t1x9gknd 6794 6 comparing compare VBG cord-010119-t1x9gknd 6794 7 controls control NNS cord-010119-t1x9gknd 6794 8 with with IN cord-010119-t1x9gknd 6794 9 neutropenia neutropenia NN cord-010119-t1x9gknd 6794 10 for for IN cord-010119-t1x9gknd 6794 11 any any DT cord-010119-t1x9gknd 6794 12 reason reason NN cord-010119-t1x9gknd 6794 13 to to IN cord-010119-t1x9gknd 6794 14 our -PRON- PRP$ cord-010119-t1x9gknd 6794 15 BEN BEN NNP cord-010119-t1x9gknd 6794 16 population population NN cord-010119-t1x9gknd 6794 17 are be VBP cord-010119-t1x9gknd 6794 18 in in IN cord-010119-t1x9gknd 6794 19 progress progress NN cord-010119-t1x9gknd 6794 20 to to TO cord-010119-t1x9gknd 6794 21 better better RB cord-010119-t1x9gknd 6794 22 determine determine VB cord-010119-t1x9gknd 6794 23 the the DT cord-010119-t1x9gknd 6794 24 positive positive JJ cord-010119-t1x9gknd 6794 25 predictive predictive JJ cord-010119-t1x9gknd 6794 26 value value NN cord-010119-t1x9gknd 6794 27 . . . cord-010119-t1x9gknd 6795 1 These these DT cord-010119-t1x9gknd 6795 2 tests test NNS cord-010119-t1x9gknd 6795 3 were be VBD cord-010119-t1x9gknd 6795 4 compared compare VBN cord-010119-t1x9gknd 6795 5 to to IN cord-010119-t1x9gknd 6795 6 the the DT cord-010119-t1x9gknd 6795 7 ProVUE ProVUE NNP cord-010119-t1x9gknd 6795 8 for for IN cord-010119-t1x9gknd 6795 9 concordance concordance NNP cord-010119-t1x9gknd 6795 10 . . . cord-010119-t1x9gknd 6796 1 Additional additional JJ cord-010119-t1x9gknd 6796 2 samples sample NNS cord-010119-t1x9gknd 6796 3 tested test VBN cord-010119-t1x9gknd 6796 4 with with IN cord-010119-t1x9gknd 6796 5 Anti Anti NNP cord-010119-t1x9gknd 6796 6 - - NN cord-010119-t1x9gknd 6796 7 IgG,-C3d igg,-c3d JJ cord-010119-t1x9gknd 6796 8 were be VBD cord-010119-t1x9gknd 6796 9 correlated correlate VBN cord-010119-t1x9gknd 6796 10 against against IN cord-010119-t1x9gknd 6796 11 tube tube NN cord-010119-t1x9gknd 6796 12 testing testing NN cord-010119-t1x9gknd 6796 13 for for IN cord-010119-t1x9gknd 6796 14 the the DT cord-010119-t1x9gknd 6796 15 DAT DAT NNP cord-010119-t1x9gknd 6796 16 and and CC cord-010119-t1x9gknd 6796 17 antigen antigen NN cord-010119-t1x9gknd 6796 18 typing typing NN cord-010119-t1x9gknd 6796 19 for for IN cord-010119-t1x9gknd 6796 20 : : : cord-010119-t1x9gknd 6796 21 C C NNP cord-010119-t1x9gknd 6796 22 , , , cord-010119-t1x9gknd 6796 23 c c NNP cord-010119-t1x9gknd 6796 24 , , , cord-010119-t1x9gknd 6796 25 E E NNP cord-010119-t1x9gknd 6796 26 , , , cord-010119-t1x9gknd 6796 27 e e NNP cord-010119-t1x9gknd 6796 28 , , , cord-010119-t1x9gknd 6796 29 and and CC cord-010119-t1x9gknd 6796 30 K. K. NNP cord-010119-t1x9gknd 6796 31 Results Results NNP cord-010119-t1x9gknd 6796 32 / / SYM cord-010119-t1x9gknd 6796 33 Findings finding NNS cord-010119-t1x9gknd 6796 34 : : : cord-010119-t1x9gknd 6797 1 The the DT cord-010119-t1x9gknd 6797 2 IH-1000 ih-1000 NN cord-010119-t1x9gknd 6797 3 had have VBD cord-010119-t1x9gknd 6797 4 100 100 CD cord-010119-t1x9gknd 6797 5 % % NN cord-010119-t1x9gknd 6797 6 concordance concordance NN cord-010119-t1x9gknd 6797 7 for for IN cord-010119-t1x9gknd 6797 8 all all DT cord-010119-t1x9gknd 6797 9 blood blood NN cord-010119-t1x9gknd 6797 10 grouping grouping NN cord-010119-t1x9gknd 6797 11 assays assay NNS cord-010119-t1x9gknd 6797 12 . . . cord-010119-t1x9gknd 6798 1 For for IN cord-010119-t1x9gknd 6798 2 AHG AHG NNP cord-010119-t1x9gknd 6798 3 assays assay NNS cord-010119-t1x9gknd 6798 4 , , , cord-010119-t1x9gknd 6798 5 the the DT cord-010119-t1x9gknd 6798 6 IH-1000 ih-1000 NN cord-010119-t1x9gknd 6798 7 detected detect VBD cord-010119-t1x9gknd 6798 8 an an DT cord-010119-t1x9gknd 6798 9 anti anti JJ cord-010119-t1x9gknd 6798 10 - - NN cord-010119-t1x9gknd 6798 11 Jka1E jka1e JJ cord-010119-t1x9gknd 6798 12 , , , cord-010119-t1x9gknd 6798 13 anti anti JJ cord-010119-t1x9gknd 6798 14 - - JJ cord-010119-t1x9gknd 6798 15 Fya Fya NNP cord-010119-t1x9gknd 6798 16 1 1 CD cord-010119-t1x9gknd 6798 17 warm warm JJ cord-010119-t1x9gknd 6798 18 antibody antibody NN cord-010119-t1x9gknd 6798 19 , , , cord-010119-t1x9gknd 6798 20 antibody antibody NN cord-010119-t1x9gknd 6798 21 to to IN cord-010119-t1x9gknd 6798 22 a a DT cord-010119-t1x9gknd 6798 23 high high JJ cord-010119-t1x9gknd 6798 24 incidence incidence NN cord-010119-t1x9gknd 6798 25 antigen antigen NN cord-010119-t1x9gknd 6798 26 and and CC cord-010119-t1x9gknd 6798 27 a a DT cord-010119-t1x9gknd 6798 28 warm warm JJ cord-010119-t1x9gknd 6798 29 antibody antibody NN cord-010119-t1x9gknd 6798 30 that that WDT cord-010119-t1x9gknd 6798 31 were be VBD cord-010119-t1x9gknd 6798 32 missed miss VBN cord-010119-t1x9gknd 6798 33 by by IN cord-010119-t1x9gknd 6798 34 the the DT cord-010119-t1x9gknd 6798 35 ProVUE ProVUE NNP cord-010119-t1x9gknd 6798 36 . . . cord-010119-t1x9gknd 6799 1 The the DT cord-010119-t1x9gknd 6799 2 IH-1000 ih-1000 NN cord-010119-t1x9gknd 6799 3 identified identify VBD cord-010119-t1x9gknd 6799 4 one one CD cord-010119-t1x9gknd 6799 5 additional additional JJ cord-010119-t1x9gknd 6799 6 anti anti NNS cord-010119-t1x9gknd 6799 7 - - NN cord-010119-t1x9gknd 6799 8 E e JJ cord-010119-t1x9gknd 6799 9 not not RB cord-010119-t1x9gknd 6799 10 identified identify VBN cord-010119-t1x9gknd 6799 11 on on IN cord-010119-t1x9gknd 6800 1 the the DT cord-010119-t1x9gknd 6800 2 ProVUE ProVUE NNP cord-010119-t1x9gknd 6800 3 . . . cord-010119-t1x9gknd 6800 4 Discrepancies discrepancy NNS cord-010119-t1x9gknd 6800 5 were be VBD cord-010119-t1x9gknd 6800 6 also also RB cord-010119-t1x9gknd 6800 7 noted note VBN cord-010119-t1x9gknd 6800 8 with with IN cord-010119-t1x9gknd 6800 9 the the DT cord-010119-t1x9gknd 6800 10 non non JJ cord-010119-t1x9gknd 6800 11 - - JJ cord-010119-t1x9gknd 6800 12 cord cord JJ cord-010119-t1x9gknd 6800 13 DAT DAT NNP cord-010119-t1x9gknd 6800 14 results result NNS cord-010119-t1x9gknd 6800 15 . . . cord-010119-t1x9gknd 6801 1 Five five CD cord-010119-t1x9gknd 6801 2 samples sample NNS cord-010119-t1x9gknd 6801 3 were be VBD cord-010119-t1x9gknd 6801 4 positive positive JJ cord-010119-t1x9gknd 6801 5 on on IN cord-010119-t1x9gknd 6801 6 the the DT cord-010119-t1x9gknd 6801 7 IH-1000 ih-1000 NN cord-010119-t1x9gknd 6801 8 with with IN cord-010119-t1x9gknd 6801 9 Anti anti JJ cord-010119-t1x9gknd 6801 10 - - JJ cord-010119-t1x9gknd 6801 11 IgG,-C3d igg,-c3d JJ cord-010119-t1x9gknd 6801 12 vs. vs. FW cord-010119-t1x9gknd 6801 13 tube tube NN cord-010119-t1x9gknd 6801 14 testing testing NN cord-010119-t1x9gknd 6801 15 ; ; : cord-010119-t1x9gknd 6801 16 reflecting reflect VBG cord-010119-t1x9gknd 6801 17 the the DT cord-010119-t1x9gknd 6801 18 increased increase VBN cord-010119-t1x9gknd 6801 19 sensitivity sensitivity NN cord-010119-t1x9gknd 6801 20 of of IN cord-010119-t1x9gknd 6801 21 gel gel NN cord-010119-t1x9gknd 6801 22 methodology methodology NN cord-010119-t1x9gknd 6801 23 over over IN cord-010119-t1x9gknd 6801 24 tube tube NN cord-010119-t1x9gknd 6801 25 . . . cord-010119-t1x9gknd 6802 1 The the DT cord-010119-t1x9gknd 6802 2 table table NN cord-010119-t1x9gknd 6802 3 below below IN cord-010119-t1x9gknd 6802 4 summarizes summarize VBZ cord-010119-t1x9gknd 6802 5 the the DT cord-010119-t1x9gknd 6802 6 results result NNS cord-010119-t1x9gknd 6802 7 . . . cord-010119-t1x9gknd 6803 1 Conclusion conclusion NN cord-010119-t1x9gknd 6803 2 : : : cord-010119-t1x9gknd 6804 1 This this DT cord-010119-t1x9gknd 6804 2 study study NN cord-010119-t1x9gknd 6804 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 6804 4 that that IN cord-010119-t1x9gknd 6804 5 the the DT cord-010119-t1x9gknd 6804 6 IH-1000 ih-1000 NN cord-010119-t1x9gknd 6804 7 analyzer analyzer NN cord-010119-t1x9gknd 6804 8 and and CC cord-010119-t1x9gknd 6804 9 associated associate VBD cord-010119-t1x9gknd 6804 10 IH IH NNP cord-010119-t1x9gknd 6804 11 - - HYPH cord-010119-t1x9gknd 6804 12 System System NNP cord-010119-t1x9gknd 6804 13 TM TM NNP cord-010119-t1x9gknd 6804 14 Gel Gel NNP cord-010119-t1x9gknd 6804 15 Cards Cards NNPS cord-010119-t1x9gknd 6804 16 are be VBP cord-010119-t1x9gknd 6804 17 equivalent equivalent JJ cord-010119-t1x9gknd 6804 18 to to IN cord-010119-t1x9gknd 6804 19 the the DT cord-010119-t1x9gknd 6804 20 ORTHO ORTHO NNP cord-010119-t1x9gknd 6804 21 ProVUE ProVUE NNP cord-010119-t1x9gknd 6804 22 . . . cord-010119-t1x9gknd 6805 1 With with IN cord-010119-t1x9gknd 6805 2 random random JJ cord-010119-t1x9gknd 6805 3 access access NN cord-010119-t1x9gknd 6805 4 capability capability NN cord-010119-t1x9gknd 6805 5 , , , cord-010119-t1x9gknd 6805 6 minimal minimal JJ cord-010119-t1x9gknd 6805 7 operator operator NN cord-010119-t1x9gknd 6805 8 touchpoints touchpoint NNS cord-010119-t1x9gknd 6805 9 , , , cord-010119-t1x9gknd 6805 10 broad broad JJ cord-010119-t1x9gknd 6805 11 test test NN cord-010119-t1x9gknd 6805 12 menu menu NN cord-010119-t1x9gknd 6805 13 and and CC cord-010119-t1x9gknd 6805 14 excellent excellent JJ cord-010119-t1x9gknd 6805 15 assay assay NN cord-010119-t1x9gknd 6805 16 performance performance NN cord-010119-t1x9gknd 6805 17 , , , cord-010119-t1x9gknd 6805 18 the the DT cord-010119-t1x9gknd 6805 19 IH-1000 ih-1000 NN cord-010119-t1x9gknd 6805 20 is be VBZ cord-010119-t1x9gknd 6805 21 an an DT cord-010119-t1x9gknd 6805 22 ideal ideal JJ cord-010119-t1x9gknd 6805 23 immunohematology immunohematology NN cord-010119-t1x9gknd 6805 24 system system NN cord-010119-t1x9gknd 6805 25 for for IN cord-010119-t1x9gknd 6805 26 the the DT cord-010119-t1x9gknd 6805 27 hospital hospital NN cord-010119-t1x9gknd 6805 28 transfusion transfusion NN cord-010119-t1x9gknd 6805 29 service service NN cord-010119-t1x9gknd 6805 30 environment environment NN cord-010119-t1x9gknd 6805 31 . . . cord-010119-t1x9gknd 6806 1 Chris Chris NNP cord-010119-t1x9gknd 6806 2 Elliott Elliott NNP cord-010119-t1x9gknd 6806 3 * * NFP cord-010119-t1x9gknd 6806 4 , , , cord-010119-t1x9gknd 6806 5 Susan Susan NNP cord-010119-t1x9gknd 6806 6 Barnes Barnes NNP cord-010119-t1x9gknd 6806 7 , , , cord-010119-t1x9gknd 6806 8 Fiona Fiona NNP cord-010119-t1x9gknd 6806 9 Lisle Lisle NNP cord-010119-t1x9gknd 6806 10 , , , cord-010119-t1x9gknd 6806 11 Debra Debra NNP cord-010119-t1x9gknd 6806 12 Smith Smith NNP cord-010119-t1x9gknd 6806 13 and and CC cord-010119-t1x9gknd 6806 14 Whitehouse Whitehouse NNP cord-010119-t1x9gknd 6806 15 Natalie Natalie NNP cord-010119-t1x9gknd 6806 16 . . . cord-010119-t1x9gknd 6807 1 Background Background NNP cord-010119-t1x9gknd 6807 2 / / SYM cord-010119-t1x9gknd 6807 3 Case Case NNP cord-010119-t1x9gknd 6807 4 Studies Studies NNPS cord-010119-t1x9gknd 6807 5 : : : cord-010119-t1x9gknd 6807 6 The the DT cord-010119-t1x9gknd 6807 7 Erytra Erytra NNP cord-010119-t1x9gknd 6807 8 EflexisV eflexisv NN cord-010119-t1x9gknd 6807 9 R R NNP cord-010119-t1x9gknd 6807 10 ( ( -LRB- cord-010119-t1x9gknd 6807 11 Grifols Grifols NNP cord-010119-t1x9gknd 6807 12 ) ) -RRB- cord-010119-t1x9gknd 6807 13 is be VBZ cord-010119-t1x9gknd 6807 14 a a DT cord-010119-t1x9gknd 6807 15 new new JJ cord-010119-t1x9gknd 6807 16 fully fully RB cord-010119-t1x9gknd 6807 17 automated automate VBN cord-010119-t1x9gknd 6807 18 , , , cord-010119-t1x9gknd 6807 19 mid mid JJ cord-010119-t1x9gknd 6807 20 - - NN cord-010119-t1x9gknd 6807 21 size size NN cord-010119-t1x9gknd 6807 22 analyzer analyzer NN cord-010119-t1x9gknd 6807 23 that that WDT cord-010119-t1x9gknd 6807 24 performs perform VBZ cord-010119-t1x9gknd 6807 25 pre pre JJ cord-010119-t1x9gknd 6807 26 - - JJ cord-010119-t1x9gknd 6807 27 transfusion transfusion JJ cord-010119-t1x9gknd 6807 28 compatibility compatibility NN cord-010119-t1x9gknd 6807 29 testing testing NN cord-010119-t1x9gknd 6807 30 using use VBG cord-010119-t1x9gknd 6807 31 DG DG NNP cord-010119-t1x9gknd 6807 32 GelV GelV NNP cord-010119-t1x9gknd 6807 33 R R NNP cord-010119-t1x9gknd 6807 34 technology technology NN cord-010119-t1x9gknd 6807 35 . . . cord-010119-t1x9gknd 6808 1 Erytra Erytra NNP cord-010119-t1x9gknd 6808 2 EflexisV eflexisv IN cord-010119-t1x9gknd 6808 3 R r NN cord-010119-t1x9gknd 6808 4 analyzer analyzer NN cord-010119-t1x9gknd 6808 5 performance performance NN cord-010119-t1x9gknd 6808 6 , , , cord-010119-t1x9gknd 6808 7 usability usability NN cord-010119-t1x9gknd 6808 8 and and CC cord-010119-t1x9gknd 6808 9 adaptability adaptability NN cord-010119-t1x9gknd 6808 10 to to IN cord-010119-t1x9gknd 6808 11 different different JJ cord-010119-t1x9gknd 6808 12 workflows workflow NNS cord-010119-t1x9gknd 6808 13 was be VBD cord-010119-t1x9gknd 6808 14 evaluated evaluate VBN cord-010119-t1x9gknd 6808 15 in in IN cord-010119-t1x9gknd 6808 16 the the DT cord-010119-t1x9gknd 6808 17 routine routine JJ cord-010119-t1x9gknd 6808 18 environment environment NN cord-010119-t1x9gknd 6808 19 of of IN cord-010119-t1x9gknd 6808 20 a a DT cord-010119-t1x9gknd 6808 21 large large JJ cord-010119-t1x9gknd 6808 22 UK UK NNP cord-010119-t1x9gknd 6808 23 acute acute JJ cord-010119-t1x9gknd 6808 24 hospital hospital NN cord-010119-t1x9gknd 6808 25 transfusion transfusion NN cord-010119-t1x9gknd 6808 26 laboratory laboratory NN cord-010119-t1x9gknd 6808 27 . . . cord-010119-t1x9gknd 6809 1 Study Study NNP cord-010119-t1x9gknd 6809 2 Design Design NNP cord-010119-t1x9gknd 6809 3 / / SYM cord-010119-t1x9gknd 6809 4 Methods method NNS cord-010119-t1x9gknd 6809 5 : : : cord-010119-t1x9gknd 6809 6 A a DT cord-010119-t1x9gknd 6809 7 comparison comparison NN cord-010119-t1x9gknd 6809 8 study study NN cord-010119-t1x9gknd 6809 9 was be VBD cord-010119-t1x9gknd 6809 10 performed perform VBN cord-010119-t1x9gknd 6809 11 between between IN cord-010119-t1x9gknd 6809 12 the the DT cord-010119-t1x9gknd 6809 13 Erytra Erytra NNP cord-010119-t1x9gknd 6809 14 EflexisV EflexisV NNP cord-010119-t1x9gknd 6809 15 R R NNP cord-010119-t1x9gknd 6809 16 and and CC cord-010119-t1x9gknd 6809 17 Erytra Erytra NNP cord-010119-t1x9gknd 6809 18 ( ( -LRB- cord-010119-t1x9gknd 6809 19 our -PRON- PRP$ cord-010119-t1x9gknd 6809 20 routine routine JJ cord-010119-t1x9gknd 6809 21 system system NN cord-010119-t1x9gknd 6809 22 providing provide VBG cord-010119-t1x9gknd 6809 23 the the DT cord-010119-t1x9gknd 6809 24 reference reference NN cord-010119-t1x9gknd 6809 25 platform platform NN cord-010119-t1x9gknd 6809 26 ) ) -RRB- cord-010119-t1x9gknd 6809 27 . . . cord-010119-t1x9gknd 6810 1 A a DT cord-010119-t1x9gknd 6810 2 total total NN cord-010119-t1x9gknd 6810 3 of of IN cord-010119-t1x9gknd 6810 4 2944 2944 CD cord-010119-t1x9gknd 6810 5 tests test NNS cord-010119-t1x9gknd 6810 6 were be VBD cord-010119-t1x9gknd 6810 7 performed perform VBN cord-010119-t1x9gknd 6810 8 on on IN cord-010119-t1x9gknd 6810 9 1,214 1,214 CD cord-010119-t1x9gknd 6810 10 adult adult NN cord-010119-t1x9gknd 6810 11 patient patient NN cord-010119-t1x9gknd 6810 12 samples sample NNS cord-010119-t1x9gknd 6810 13 and and CC cord-010119-t1x9gknd 6810 14 208 208 CD cord-010119-t1x9gknd 6810 15 donor donor NN cord-010119-t1x9gknd 6810 16 red red JJ cord-010119-t1x9gknd 6810 17 cell cell NN cord-010119-t1x9gknd 6810 18 units unit NNS cord-010119-t1x9gknd 6810 19 . . . cord-010119-t1x9gknd 6811 1 ErytraV ErytraV NNS cord-010119-t1x9gknd 6811 2 R R NNP cord-010119-t1x9gknd 6811 3 Eflexis Eflexis NNP cord-010119-t1x9gknd 6811 4 performance performance NN cord-010119-t1x9gknd 6811 5 was be VBD cord-010119-t1x9gknd 6811 6 evaluated evaluate VBN cord-010119-t1x9gknd 6811 7 according accord VBG cord-010119-t1x9gknd 6811 8 to to IN cord-010119-t1x9gknd 6811 9 a a DT cord-010119-t1x9gknd 6811 10 series series NN cord-010119-t1x9gknd 6811 11 of of IN cord-010119-t1x9gknd 6811 12 scenarios scenario NNS cord-010119-t1x9gknd 6811 13 designed design VBN cord-010119-t1x9gknd 6811 14 to to TO cord-010119-t1x9gknd 6811 15 simulate simulate VB cord-010119-t1x9gknd 6811 16 routine routine JJ cord-010119-t1x9gknd 6811 17 workload workload NN cord-010119-t1x9gknd 6811 18 using use VBG cord-010119-t1x9gknd 6811 19 the the DT cord-010119-t1x9gknd 6811 20 system system NN cord-010119-t1x9gknd 6811 21 in in IN cord-010119-t1x9gknd 6811 22 different different JJ cord-010119-t1x9gknd 6811 23 configurations configuration NNS cord-010119-t1x9gknd 6811 24 . . . cord-010119-t1x9gknd 6812 1 Concordance concordance NN cord-010119-t1x9gknd 6812 2 between between IN cord-010119-t1x9gknd 6812 3 systems system NNS cord-010119-t1x9gknd 6812 4 was be VBD cord-010119-t1x9gknd 6812 5 assessed assess VBN cord-010119-t1x9gknd 6812 6 and and CC cord-010119-t1x9gknd 6812 7 discrepancies discrepancy NNS cord-010119-t1x9gknd 6812 8 analyzed analyze VBN cord-010119-t1x9gknd 6812 9 . . . cord-010119-t1x9gknd 6813 1 Time time NN cord-010119-t1x9gknd 6813 2 to to IN cord-010119-t1x9gknd 6813 3 first first JJ cord-010119-t1x9gknd 6813 4 result result NN cord-010119-t1x9gknd 6813 5 ( ( -LRB- cord-010119-t1x9gknd 6813 6 TTFR TTFR NNP cord-010119-t1x9gknd 6813 7 ) ) -RRB- cord-010119-t1x9gknd 6813 8 , , , cord-010119-t1x9gknd 6813 9 overall overall JJ cord-010119-t1x9gknd 6813 10 turn turn NN cord-010119-t1x9gknd 6813 11 - - HYPH cord-010119-t1x9gknd 6813 12 around around RP cord-010119-t1x9gknd 6813 13 time time NN cord-010119-t1x9gknd 6813 14 ( ( -LRB- cord-010119-t1x9gknd 6813 15 TAT tat NN cord-010119-t1x9gknd 6813 16 ) ) -RRB- cord-010119-t1x9gknd 6813 17 total total JJ cord-010119-t1x9gknd 6813 18 workload workload NN cord-010119-t1x9gknd 6813 19 from from IN cord-010119-t1x9gknd 6813 20 first first JJ cord-010119-t1x9gknd 6813 21 result result NN cord-010119-t1x9gknd 6813 22 to to IN cord-010119-t1x9gknd 6813 23 last last JJ cord-010119-t1x9gknd 6813 24 result result NN cord-010119-t1x9gknd 6813 25 ( ( -LRB- cord-010119-t1x9gknd 6813 26 throughput throughput NN cord-010119-t1x9gknd 6813 27 , , , cord-010119-t1x9gknd 6813 28 results result NNS cord-010119-t1x9gknd 6813 29 / / SYM cord-010119-t1x9gknd 6813 30 h h NN cord-010119-t1x9gknd 6813 31 ) ) -RRB- cord-010119-t1x9gknd 6813 32 , , , cord-010119-t1x9gknd 6813 33 manual manual JJ cord-010119-t1x9gknd 6813 34 " " `` cord-010119-t1x9gknd 6813 35 hands hand NNS cord-010119-t1x9gknd 6813 36 - - HYPH cord-010119-t1x9gknd 6813 37 on on RP cord-010119-t1x9gknd 6813 38 " " `` cord-010119-t1x9gknd 6813 39 time time NN cord-010119-t1x9gknd 6813 40 and and CC cord-010119-t1x9gknd 6813 41 walk walk VB cord-010119-t1x9gknd 6813 42 - - HYPH cord-010119-t1x9gknd 6813 43 away away RP cord-010119-t1x9gknd 6813 44 time time NN cord-010119-t1x9gknd 6813 45 were be VBD cord-010119-t1x9gknd 6813 46 all all DT cord-010119-t1x9gknd 6813 47 recorded record VBN cord-010119-t1x9gknd 6813 48 . . . cord-010119-t1x9gknd 6814 1 For for IN cord-010119-t1x9gknd 6814 2 ease ease NN cord-010119-t1x9gknd 6814 3 of of IN cord-010119-t1x9gknd 6814 4 use use NN cord-010119-t1x9gknd 6814 5 evaluation evaluation NN cord-010119-t1x9gknd 6814 6 , , , cord-010119-t1x9gknd 6814 7 we -PRON- PRP cord-010119-t1x9gknd 6814 8 ranked rank VBD cord-010119-t1x9gknd 6814 9 usability usability NN cord-010119-t1x9gknd 6814 10 features feature NNS cord-010119-t1x9gknd 6814 11 with with IN cord-010119-t1x9gknd 6814 12 number number NN cord-010119-t1x9gknd 6814 13 of of IN cord-010119-t1x9gknd 6814 14 steps step NNS cord-010119-t1x9gknd 6814 15 and and CC cord-010119-t1x9gknd 6814 16 timing timing NN cord-010119-t1x9gknd 6814 17 of of IN cord-010119-t1x9gknd 6814 18 activities activity NNS cord-010119-t1x9gknd 6814 19 including include VBG cord-010119-t1x9gknd 6814 20 sample sample NN cord-010119-t1x9gknd 6814 21 sort sort NN cord-010119-t1x9gknd 6814 22 and and CC cord-010119-t1x9gknd 6814 23 loading loading NN cord-010119-t1x9gknd 6814 24 , , , cord-010119-t1x9gknd 6814 25 routine routine JJ cord-010119-t1x9gknd 6814 26 testing testing NN cord-010119-t1x9gknd 6814 27 , , , cord-010119-t1x9gknd 6814 28 post post JJ cord-010119-t1x9gknd 6814 29 - - JJ cord-010119-t1x9gknd 6814 30 run run JJ cord-010119-t1x9gknd 6814 31 procedures procedure NNS cord-010119-t1x9gknd 6814 32 , , , cord-010119-t1x9gknd 6814 33 consumables consumable NNS cord-010119-t1x9gknd 6814 34 used use VBN cord-010119-t1x9gknd 6814 35 , , , cord-010119-t1x9gknd 6814 36 and and CC cord-010119-t1x9gknd 6814 37 space space NN cord-010119-t1x9gknd 6814 38 requirements requirement NNS cord-010119-t1x9gknd 6814 39 . . . cord-010119-t1x9gknd 6815 1 Fault fault NN cord-010119-t1x9gknd 6815 2 recognition recognition NN cord-010119-t1x9gknd 6815 3 and and CC cord-010119-t1x9gknd 6815 4 messaging messaging NN cord-010119-t1x9gknd 6815 5 was be VBD cord-010119-t1x9gknd 6815 6 assessed assess VBN cord-010119-t1x9gknd 6815 7 by by IN cord-010119-t1x9gknd 6815 8 simulating simulate VBG cord-010119-t1x9gknd 6815 9 failures failure NNS cord-010119-t1x9gknd 6815 10 e.g. e.g. RB cord-010119-t1x9gknd 6815 11 reagent reagent JJ cord-010119-t1x9gknd 6815 12 absence absence NN cord-010119-t1x9gknd 6815 13 . . . cord-010119-t1x9gknd 6816 1 Results result NNS cord-010119-t1x9gknd 6816 2 / / SYM cord-010119-t1x9gknd 6816 3 Findings finding NNS cord-010119-t1x9gknd 6816 4 : : : cord-010119-t1x9gknd 6817 1 Blood blood NN cord-010119-t1x9gknd 6817 2 grouping grouping NN cord-010119-t1x9gknd 6817 3 , , , cord-010119-t1x9gknd 6817 4 antibody antibody NN cord-010119-t1x9gknd 6817 5 screening screening NN cord-010119-t1x9gknd 6817 6 , , , cord-010119-t1x9gknd 6817 7 antibody antibody NN cord-010119-t1x9gknd 6817 8 identification identification NN cord-010119-t1x9gknd 6817 9 ( ( -LRB- cord-010119-t1x9gknd 6817 10 using use VBG cord-010119-t1x9gknd 6817 11 panels panel NNS cord-010119-t1x9gknd 6817 12 ) ) -RRB- cord-010119-t1x9gknd 6817 13 , , , cord-010119-t1x9gknd 6817 14 direct direct JJ cord-010119-t1x9gknd 6817 15 antiglobulin antiglobulin NN cord-010119-t1x9gknd 6817 16 test test NN cord-010119-t1x9gknd 6817 17 , , , cord-010119-t1x9gknd 6817 18 red red JJ cord-010119-t1x9gknd 6817 19 cell cell NN cord-010119-t1x9gknd 6817 20 phenotyping phenotyping NN cord-010119-t1x9gknd 6817 21 and and CC cord-010119-t1x9gknd 6817 22 serological serological JJ cord-010119-t1x9gknd 6817 23 crossmatching crossmatching NN cord-010119-t1x9gknd 6817 24 were be VBD cord-010119-t1x9gknd 6817 25 successfully successfully RB cord-010119-t1x9gknd 6817 26 tested test VBN cord-010119-t1x9gknd 6817 27 . . . cord-010119-t1x9gknd 6818 1 Concordant concordant JJ cord-010119-t1x9gknd 6818 2 results result NNS cord-010119-t1x9gknd 6818 3 between between IN cord-010119-t1x9gknd 6818 4 the the DT cord-010119-t1x9gknd 6818 5 Erytra Erytra NNP cord-010119-t1x9gknd 6818 6 EflexisV EflexisV NNP cord-010119-t1x9gknd 6818 7 R R NNP cord-010119-t1x9gknd 6818 8 Analyzer Analyzer NNP cord-010119-t1x9gknd 6818 9 and and CC cord-010119-t1x9gknd 6818 10 reference reference NN cord-010119-t1x9gknd 6818 11 method method NN cord-010119-t1x9gknd 6818 12 were be VBD cord-010119-t1x9gknd 6818 13 obtained obtain VBN cord-010119-t1x9gknd 6818 14 in in IN cord-010119-t1x9gknd 6818 15 99.9 99.9 CD cord-010119-t1x9gknd 6818 16 % % NN cord-010119-t1x9gknd 6818 17 of of IN cord-010119-t1x9gknd 6818 18 samples sample NNS cord-010119-t1x9gknd 6818 19 tested test VBN cord-010119-t1x9gknd 6818 20 . . . cord-010119-t1x9gknd 6819 1 There there EX cord-010119-t1x9gknd 6819 2 were be VBD cord-010119-t1x9gknd 6819 3 4 4 CD cord-010119-t1x9gknd 6819 4 discrepancies discrepancy NNS cord-010119-t1x9gknd 6819 5 , , , cord-010119-t1x9gknd 6819 6 all all DT cord-010119-t1x9gknd 6819 7 antibody antibody NN cord-010119-t1x9gknd 6819 8 screening screening NN cord-010119-t1x9gknd 6819 9 ( ( -LRB- cord-010119-t1x9gknd 6819 10 2 2 CD cord-010119-t1x9gknd 6819 11 false false JJ cord-010119-t1x9gknd 6819 12 positives positive NNS cord-010119-t1x9gknd 6819 13 , , , cord-010119-t1x9gknd 6819 14 1 1 CD cord-010119-t1x9gknd 6819 15 failure failure NN cord-010119-t1x9gknd 6819 16 to to TO cord-010119-t1x9gknd 6819 17 detect detect VB cord-010119-t1x9gknd 6819 18 a a DT cord-010119-t1x9gknd 6819 19 very very RB cord-010119-t1x9gknd 6819 20 weak weak JJ cord-010119-t1x9gknd 6819 21 prophylactic prophylactic JJ cord-010119-t1x9gknd 6819 22 anti anti FW cord-010119-t1x9gknd 6819 23 D d NN cord-010119-t1x9gknd 6819 24 and and CC cord-010119-t1x9gknd 6819 25 1 1 CD cord-010119-t1x9gknd 6819 26 positive positive JJ cord-010119-t1x9gknd 6819 27 reaction reaction NN cord-010119-t1x9gknd 6819 28 not not RB cord-010119-t1x9gknd 6819 29 detected detect VBN cord-010119-t1x9gknd 6819 30 on on IN cord-010119-t1x9gknd 6819 31 the the DT cord-010119-t1x9gknd 6819 32 Erytra Erytra NNP cord-010119-t1x9gknd 6819 33 but but CC cord-010119-t1x9gknd 6819 34 panels panel NNS cord-010119-t1x9gknd 6819 35 on on IN cord-010119-t1x9gknd 6819 36 both both DT cord-010119-t1x9gknd 6819 37 systems system NNS cord-010119-t1x9gknd 6819 38 suggested suggest VBD cord-010119-t1x9gknd 6819 39 a a DT cord-010119-t1x9gknd 6819 40 genuine genuine JJ cord-010119-t1x9gknd 6819 41 anti anti JJ cord-010119-t1x9gknd 6819 42 Cw Cw NNP cord-010119-t1x9gknd 6819 43 ) ) -RRB- cord-010119-t1x9gknd 6819 44 . . . cord-010119-t1x9gknd 6820 1 TTFR TTFR NNP cord-010119-t1x9gknd 6820 2 and and CC cord-010119-t1x9gknd 6820 3 TAT TAT NNP cord-010119-t1x9gknd 6820 4 depended depend VBD cord-010119-t1x9gknd 6820 5 significantly significantly RB cord-010119-t1x9gknd 6820 6 on on IN cord-010119-t1x9gknd 6820 7 a a DT cord-010119-t1x9gknd 6820 8 number number NN cord-010119-t1x9gknd 6820 9 of of IN cord-010119-t1x9gknd 6820 10 factors factor NNS cord-010119-t1x9gknd 6820 11 including include VBG cord-010119-t1x9gknd 6820 12 ; ; : cord-010119-t1x9gknd 6820 13 number number NN cord-010119-t1x9gknd 6820 14 and and CC cord-010119-t1x9gknd 6820 15 variety variety NN cord-010119-t1x9gknd 6820 16 of of IN cord-010119-t1x9gknd 6820 17 tests test NNS cord-010119-t1x9gknd 6820 18 requested request VBN cord-010119-t1x9gknd 6820 19 and and CC cord-010119-t1x9gknd 6820 20 whether whether IN cord-010119-t1x9gknd 6820 21 the the DT cord-010119-t1x9gknd 6820 22 STAT stat NN cord-010119-t1x9gknd 6820 23 functions function NNS cord-010119-t1x9gknd 6820 24 were be VBD cord-010119-t1x9gknd 6820 25 activated activate VBN cord-010119-t1x9gknd 6820 26 . . . cord-010119-t1x9gknd 6821 1 The the DT cord-010119-t1x9gknd 6821 2 analyser analyser NN cord-010119-t1x9gknd 6821 3 seemed seem VBD cord-010119-t1x9gknd 6821 4 to to TO cord-010119-t1x9gknd 6821 5 prioritise prioritise VB cord-010119-t1x9gknd 6821 6 antibody antibody NN cord-010119-t1x9gknd 6821 7 screening screen VBG cord-010119-t1x9gknd 6821 8 Prioritization Prioritization NNP cord-010119-t1x9gknd 6821 9 of of IN cord-010119-t1x9gknd 6821 10 the the DT cord-010119-t1x9gknd 6821 11 group group NN cord-010119-t1x9gknd 6821 12 , , , cord-010119-t1x9gknd 6821 13 especially especially RB cord-010119-t1x9gknd 6821 14 for for IN cord-010119-t1x9gknd 6821 15 STAT stat NN cord-010119-t1x9gknd 6821 16 samples sample NNS cord-010119-t1x9gknd 6821 17 , , , cord-010119-t1x9gknd 6821 18 was be VBD cord-010119-t1x9gknd 6821 19 considered consider VBN cord-010119-t1x9gknd 6821 20 preferable preferable JJ cord-010119-t1x9gknd 6821 21 The the DT cord-010119-t1x9gknd 6821 22 laboratory laboratory NN cord-010119-t1x9gknd 6821 23 team team NN cord-010119-t1x9gknd 6821 24 found find VBD cord-010119-t1x9gknd 6821 25 the the DT cord-010119-t1x9gknd 6821 26 software software NN cord-010119-t1x9gknd 6821 27 easy easy JJ cord-010119-t1x9gknd 6821 28 to to TO cord-010119-t1x9gknd 6821 29 use use VB cord-010119-t1x9gknd 6821 30 with with IN cord-010119-t1x9gknd 6821 31 some some DT cord-010119-t1x9gknd 6821 32 improvements improvement NNS cord-010119-t1x9gknd 6821 33 over over IN cord-010119-t1x9gknd 6821 34 existing exist VBG cord-010119-t1x9gknd 6821 35 Ertyra Ertyra NNP cord-010119-t1x9gknd 6821 36 software software NN cord-010119-t1x9gknd 6821 37 . . . cord-010119-t1x9gknd 6822 1 Physical physical JJ cord-010119-t1x9gknd 6822 2 design design NN cord-010119-t1x9gknd 6822 3 of of IN cord-010119-t1x9gknd 6822 4 the the DT cord-010119-t1x9gknd 6822 5 analyser analyser NN cord-010119-t1x9gknd 6822 6 was be VBD cord-010119-t1x9gknd 6822 7 considered consider VBN cord-010119-t1x9gknd 6822 8 good good JJ cord-010119-t1x9gknd 6822 9 with with IN cord-010119-t1x9gknd 6822 10 easy easy JJ cord-010119-t1x9gknd 6822 11 access access NN cord-010119-t1x9gknd 6822 12 to to IN cord-010119-t1x9gknd 6822 13 almost almost RB cord-010119-t1x9gknd 6822 14 all all DT cord-010119-t1x9gknd 6822 15 areas area NNS cord-010119-t1x9gknd 6822 16 . . . cord-010119-t1x9gknd 6823 1 Probe probe NN cord-010119-t1x9gknd 6823 2 changing change VBG cord-010119-t1x9gknd 6823 3 was be VBD cord-010119-t1x9gknd 6823 4 quick quick JJ cord-010119-t1x9gknd 6823 5 and and CC cord-010119-t1x9gknd 6823 6 simple simple JJ cord-010119-t1x9gknd 6823 7 . . . cord-010119-t1x9gknd 6824 1 While while IN cord-010119-t1x9gknd 6824 2 the the DT cord-010119-t1x9gknd 6824 3 analyser analyser NN cord-010119-t1x9gknd 6824 4 successfully successfully RB cord-010119-t1x9gknd 6824 5 flagged flag VBD cord-010119-t1x9gknd 6824 6 all all DT cord-010119-t1x9gknd 6824 7 error error NN cord-010119-t1x9gknd 6824 8 scenarios scenario NNS cord-010119-t1x9gknd 6824 9 some some DT cord-010119-t1x9gknd 6824 10 messages message NNS cord-010119-t1x9gknd 6824 11 were be VBD cord-010119-t1x9gknd 6824 12 considered consider VBN cord-010119-t1x9gknd 6824 13 misleading misleading JJ cord-010119-t1x9gknd 6824 14 and and CC cord-010119-t1x9gknd 6824 15 could could MD cord-010119-t1x9gknd 6824 16 be be VB cord-010119-t1x9gknd 6824 17 better well RBR cord-010119-t1x9gknd 6824 18 phrased phrase VBN cord-010119-t1x9gknd 6824 19 . . . cord-010119-t1x9gknd 6825 1 Conclusion conclusion NN cord-010119-t1x9gknd 6825 2 : : : cord-010119-t1x9gknd 6826 1 Results result NNS cord-010119-t1x9gknd 6826 2 showed show VBD cord-010119-t1x9gknd 6826 3 the the DT cord-010119-t1x9gknd 6826 4 Erytra Erytra NNP cord-010119-t1x9gknd 6826 5 EflexisV EflexisV NNP cord-010119-t1x9gknd 6826 6 R R NNP cord-010119-t1x9gknd 6826 7 offered offer VBD cord-010119-t1x9gknd 6826 8 a a DT cord-010119-t1x9gknd 6826 9 robust robust JJ cord-010119-t1x9gknd 6826 10 automated automate VBN cord-010119-t1x9gknd 6826 11 solution solution NN cord-010119-t1x9gknd 6826 12 for for IN cord-010119-t1x9gknd 6826 13 routine routine JJ cord-010119-t1x9gknd 6826 14 transfusion transfusion NN cord-010119-t1x9gknd 6826 15 testing testing NN cord-010119-t1x9gknd 6826 16 . . . cord-010119-t1x9gknd 6827 1 The the DT cord-010119-t1x9gknd 6827 2 device device NN cord-010119-t1x9gknd 6827 3 could could MD cord-010119-t1x9gknd 6827 4 comfortably comfortably RB cord-010119-t1x9gknd 6827 5 deal deal VB cord-010119-t1x9gknd 6827 6 with with IN cord-010119-t1x9gknd 6827 7 a a DT cord-010119-t1x9gknd 6827 8 medium medium JJ cord-010119-t1x9gknd 6827 9 laboratory laboratory NN cord-010119-t1x9gknd 6827 10 ( ( -LRB- cord-010119-t1x9gknd 6827 11 processing process VBG cord-010119-t1x9gknd 6827 12 80 80 CD cord-010119-t1x9gknd 6827 13 - - SYM cord-010119-t1x9gknd 6827 14 100 100 CD cord-010119-t1x9gknd 6827 15 group group NN cord-010119-t1x9gknd 6827 16 and and CC cord-010119-t1x9gknd 6827 17 screens screen NNS cord-010119-t1x9gknd 6827 18 per per IN cord-010119-t1x9gknd 6827 19 day day NN cord-010119-t1x9gknd 6827 20 ) ) -RRB- cord-010119-t1x9gknd 6827 21 . . . cord-010119-t1x9gknd 6828 1 It -PRON- PRP cord-010119-t1x9gknd 6828 2 is be VBZ cord-010119-t1x9gknd 6828 3 very very RB cord-010119-t1x9gknd 6828 4 flexible flexible JJ cord-010119-t1x9gknd 6828 5 being being NN cord-010119-t1x9gknd 6828 6 able able JJ cord-010119-t1x9gknd 6828 7 to to TO cord-010119-t1x9gknd 6828 8 deliver deliver VB cord-010119-t1x9gknd 6828 9 grouping grouping NN cord-010119-t1x9gknd 6828 10 , , , cord-010119-t1x9gknd 6828 11 antibody antibody NN cord-010119-t1x9gknd 6828 12 screening screening NN cord-010119-t1x9gknd 6828 13 and and CC cord-010119-t1x9gknd 6828 14 identification identification NN cord-010119-t1x9gknd 6828 15 , , , cord-010119-t1x9gknd 6828 16 DAT DAT NNP cord-010119-t1x9gknd 6828 17 , , , cord-010119-t1x9gknd 6828 18 phenotyping phenotyping NN cord-010119-t1x9gknd 6828 19 and and CC cord-010119-t1x9gknd 6828 20 serological serological JJ cord-010119-t1x9gknd 6828 21 crossmatching crossmatching NN cord-010119-t1x9gknd 6828 22 , , , cord-010119-t1x9gknd 6828 23 compensating compensate VBG cord-010119-t1x9gknd 6828 24 for for IN cord-010119-t1x9gknd 6828 25 its -PRON- PRP$ cord-010119-t1x9gknd 6828 26 ' ' `` cord-010119-t1x9gknd 6828 27 single single JJ cord-010119-t1x9gknd 6828 28 probe probe NN cord-010119-t1x9gknd 6828 29 and and CC cord-010119-t1x9gknd 6828 30 wash wash NN cord-010119-t1x9gknd 6828 31 station station NN cord-010119-t1x9gknd 6828 32 by by IN cord-010119-t1x9gknd 6828 33 clever clever JJ cord-010119-t1x9gknd 6828 34 use use NN cord-010119-t1x9gknd 6828 35 of of IN cord-010119-t1x9gknd 6828 36 incubators incubator NNS cord-010119-t1x9gknd 6828 37 , , , cord-010119-t1x9gknd 6828 38 centrifuges centrifuge NNS cord-010119-t1x9gknd 6828 39 and and CC cord-010119-t1x9gknd 6828 40 design design NN cord-010119-t1x9gknd 6828 41 features feature NNS cord-010119-t1x9gknd 6828 42 . . . cord-010119-t1x9gknd 6829 1 This this DT cord-010119-t1x9gknd 6829 2 allows allow VBZ cord-010119-t1x9gknd 6829 3 a a DT cord-010119-t1x9gknd 6829 4 compact compact JJ cord-010119-t1x9gknd 6829 5 design design NN cord-010119-t1x9gknd 6829 6 with with IN cord-010119-t1x9gknd 6829 7 maximum maximum JJ cord-010119-t1x9gknd 6829 8 flexibility flexibility NN cord-010119-t1x9gknd 6829 9 without without IN cord-010119-t1x9gknd 6829 10 compromising compromise VBG cord-010119-t1x9gknd 6829 11 on on IN cord-010119-t1x9gknd 6829 12 turnaround turnaround NN cord-010119-t1x9gknd 6829 13 times time NNS cord-010119-t1x9gknd 6830 1 CP201 cp201 CD cord-010119-t1x9gknd 6830 2 Evaluation evaluation NN cord-010119-t1x9gknd 6830 3 of of IN cord-010119-t1x9gknd 6830 4 Two two CD cord-010119-t1x9gknd 6830 5 Monoclonal Monoclonal NNP cord-010119-t1x9gknd 6830 6 Anti Anti NNP cord-010119-t1x9gknd 6830 7 - - NN cord-010119-t1x9gknd 6830 8 e e NN cord-010119-t1x9gknd 6831 1 As as IN cord-010119-t1x9gknd 6831 2 Reagents reagent NNS cord-010119-t1x9gknd 6831 3 for for IN cord-010119-t1x9gknd 6831 4 the the DT cord-010119-t1x9gknd 6831 5 Detection detection NN cord-010119-t1x9gknd 6831 6 of of IN cord-010119-t1x9gknd 6831 7 the the DT cord-010119-t1x9gknd 6831 8 Rh Rh NNP cord-010119-t1x9gknd 6831 9 e e NN cord-010119-t1x9gknd 6831 10 Antigen Antigen NNP cord-010119-t1x9gknd 6831 11 and and CC cord-010119-t1x9gknd 6831 12 Its -PRON- PRP$ cord-010119-t1x9gknd 6831 13 Variants Variants NNPS cord-010119-t1x9gknd 6832 1 Gregory Gregory NNP cord-010119-t1x9gknd 6832 2 A. A. NNP cord-010119-t1x9gknd 6832 3 Denomme Denomme NNP cord-010119-t1x9gknd 6832 4 * * NFP cord-010119-t1x9gknd 6832 5 1 1 CD cord-010119-t1x9gknd 6832 6 , , , cord-010119-t1x9gknd 6832 7 Kathleen Kathleen NNP cord-010119-t1x9gknd 6832 8 Bensing Bensing NNP cord-010119-t1x9gknd 6832 9 1 1 CD cord-010119-t1x9gknd 6832 10 , , , cord-010119-t1x9gknd 6832 11 Michael Michael NNP cord-010119-t1x9gknd 6832 12 Schanen Schanen NNP cord-010119-t1x9gknd 6832 13 1 1 CD cord-010119-t1x9gknd 6832 14 , , , cord-010119-t1x9gknd 6832 15 Cindy Cindy NNP cord-010119-t1x9gknd 6832 16 Piefer Piefer NNP cord-010119-t1x9gknd 6832 17 1 1 CD cord-010119-t1x9gknd 6832 18 , , , cord-010119-t1x9gknd 6832 19 Randall Randall NNP cord-010119-t1x9gknd 6832 20 W. W. NNP cord-010119-t1x9gknd 6832 21 Velliquette Velliquette NNP cord-010119-t1x9gknd 6832 22 2 2 CD cord-010119-t1x9gknd 6832 23 , , , cord-010119-t1x9gknd 6832 24 Christine Christine NNP cord-010119-t1x9gknd 6832 25 Lomas Lomas NNP cord-010119-t1x9gknd 6832 26 - - HYPH cord-010119-t1x9gknd 6832 27 Francis Francis NNP cord-010119-t1x9gknd 6832 28 2 2 CD cord-010119-t1x9gknd 6832 29 and and CC cord-010119-t1x9gknd 6832 30 Connie Connie NNP cord-010119-t1x9gknd 6832 31 M. M. NNP cord-010119-t1x9gknd 6832 32 Westhoff Westhoff NNP cord-010119-t1x9gknd 6832 33 2 2 CD cord-010119-t1x9gknd 6832 34 . . . cord-010119-t1x9gknd 6833 1 1 1 LS cord-010119-t1x9gknd 6834 1 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 6834 2 Reference Reference NNP cord-010119-t1x9gknd 6834 3 Laboratory Laboratory NNP cord-010119-t1x9gknd 6834 4 , , , cord-010119-t1x9gknd 6834 5 Versiti Versiti NNP cord-010119-t1x9gknd 6834 6 / / SYM cord-010119-t1x9gknd 6834 7 BloodCenter BloodCenter NNP cord-010119-t1x9gknd 6834 8 of of IN cord-010119-t1x9gknd 6834 9 Wisconsin Wisconsin NNP cord-010119-t1x9gknd 6834 10 , , , cord-010119-t1x9gknd 6834 11 2 2 CD cord-010119-t1x9gknd 6834 12 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 6834 13 and and CC cord-010119-t1x9gknd 6834 14 Genomics Genomics NNPS cord-010119-t1x9gknd 6834 15 Laboratory Laboratory NNP cord-010119-t1x9gknd 6834 16 , , , cord-010119-t1x9gknd 6834 17 New New NNP cord-010119-t1x9gknd 6834 18 York York NNP cord-010119-t1x9gknd 6834 19 Blood Blood NNP cord-010119-t1x9gknd 6834 20 Center Center NNP cord-010119-t1x9gknd 6834 21 Background Background NNP cord-010119-t1x9gknd 6834 22 / / SYM cord-010119-t1x9gknd 6834 23 Case Case NNP cord-010119-t1x9gknd 6834 24 Studies Studies NNPS cord-010119-t1x9gknd 6834 25 : : : cord-010119-t1x9gknd 6835 1 Monoclonal monoclonal JJ cord-010119-t1x9gknd 6835 2 antibodies antibody NNS cord-010119-t1x9gknd 6835 3 are be VBP cord-010119-t1x9gknd 6835 4 used use VBN cord-010119-t1x9gknd 6835 5 as as IN cord-010119-t1x9gknd 6835 6 reagents reagent NNS cord-010119-t1x9gknd 6835 7 for for IN cord-010119-t1x9gknd 6835 8 automated automated JJ cord-010119-t1x9gknd 6835 9 and and CC cord-010119-t1x9gknd 6835 10 manual manual JJ cord-010119-t1x9gknd 6835 11 phenotyping phenotyping NN cord-010119-t1x9gknd 6835 12 . . . cord-010119-t1x9gknd 6836 1 False false JJ cord-010119-t1x9gknd 6836 2 negative negative JJ cord-010119-t1x9gknd 6836 3 phenotypings phenotyping NNS cord-010119-t1x9gknd 6836 4 have have VBP cord-010119-t1x9gknd 6836 5 implications implication NNS cord-010119-t1x9gknd 6836 6 for for IN cord-010119-t1x9gknd 6836 7 variant variant JJ cord-010119-t1x9gknd 6836 8 antigens antigen NNS cord-010119-t1x9gknd 6836 9 ; ; : cord-010119-t1x9gknd 6836 10 e.g. e.g. RB cord-010119-t1x9gknd 6836 11 altered alter VBN cord-010119-t1x9gknd 6836 12 C c NN cord-010119-t1x9gknd 6836 13 antigen antigen NN cord-010119-t1x9gknd 6836 14 mistyped mistype VBD cord-010119-t1x9gknd 6836 15 as as IN cord-010119-t1x9gknd 6836 16 a a DT cord-010119-t1x9gknd 6836 17 Cblood Cblood NNP cord-010119-t1x9gknd 6836 18 unit unit NN cord-010119-t1x9gknd 6836 19 stimulating stimulate VBG cord-010119-t1x9gknd 6836 20 anti anti JJ cord-010119-t1x9gknd 6836 21 - - JJ cord-010119-t1x9gknd 6836 22 C C NNP cord-010119-t1x9gknd 6836 23 in in IN cord-010119-t1x9gknd 6836 24 a a DT cord-010119-t1x9gknd 6836 25 C c NN cord-010119-t1x9gknd 6836 26 - - HYPH cord-010119-t1x9gknd 6836 27 recipient recipient NN cord-010119-t1x9gknd 6836 28 . . . cord-010119-t1x9gknd 6837 1 The the DT cord-010119-t1x9gknd 6837 2 development development NN cord-010119-t1x9gknd 6837 3 of of IN cord-010119-t1x9gknd 6837 4 new new JJ cord-010119-t1x9gknd 6837 5 7/0 7/0 CD cord-010119-t1x9gknd 6837 6 7/0 7/0 CD cord-010119-t1x9gknd 6837 7 7/0 7/0 CD cord-010119-t1x9gknd 6837 8 ceCF ceCF NNP cord-010119-t1x9gknd 6837 9 1/1 1/1 CD cord-010119-t1x9gknd 6837 10 2/0 2/0 CD cord-010119-t1x9gknd 6837 11 2/0 2/0 CD cord-010119-t1x9gknd 6838 1 RHCE*ce rhce*ce RB cord-010119-t1x9gknd 6838 2 or or CC cord-010119-t1x9gknd 6838 3 RHCE*Ce rhce*ce NN cord-010119-t1x9gknd 6838 4 compound compound NN cord-010119-t1x9gknd 6838 5 heterozygotes heterozygote NNS cord-010119-t1x9gknd 6838 6 ce254 ce254 VBD cord-010119-t1x9gknd 6838 7 G G NNP cord-010119-t1x9gknd 6838 8 1 1 CD cord-010119-t1x9gknd 6838 9 ce733 ce733 NNP cord-010119-t1x9gknd 6838 10 G G NNP cord-010119-t1x9gknd 6838 11 or or CC cord-010119-t1x9gknd 6838 12 ce48C,733 ce48C,733 : cord-010119-t1x9gknd 6838 13 G g NN cord-010119-t1x9gknd 6838 14 or or CC cord-010119-t1x9gknd 6838 15 ceS ces JJ cord-010119-t1x9gknd 6838 16 or or CC cord-010119-t1x9gknd 6838 17 ceTI ceti NN cord-010119-t1x9gknd 6838 18 6/0 6/0 CD cord-010119-t1x9gknd 6838 19 6/0 6/0 CD cord-010119-t1x9gknd 6838 20 6/0 6/0 CD cord-010119-t1x9gknd 6838 21 ce733 ce733 NNP cord-010119-t1x9gknd 6838 22 G G NNP cord-010119-t1x9gknd 6838 23 1 1 CD cord-010119-t1x9gknd 6838 24 ce48C,712 ce48c,712 CD cord-010119-t1x9gknd 6838 25 G g NN cord-010119-t1x9gknd 6838 26 or or CC cord-010119-t1x9gknd 6839 1 48C,733 48c,733 CD cord-010119-t1x9gknd 6839 2 G G NNP cord-010119-t1x9gknd 6839 3 4/0 4/0 CD cord-010119-t1x9gknd 6839 4 4/0 4/0 CD cord-010119-t1x9gknd 6839 5 4/0 4/0 CD cord-010119-t1x9gknd 6839 6 ce733 ce733 NNP cord-010119-t1x9gknd 6839 7 G G NNP cord-010119-t1x9gknd 6839 8 1 1 CD cord-010119-t1x9gknd 6839 9 ceS ce NNS cord-010119-t1x9gknd 6839 10 or or CC cord-010119-t1x9gknd 6839 11 ceMO cemo NN cord-010119-t1x9gknd 6839 12 or or CC cord-010119-t1x9gknd 6839 13 ceEK ceEK NNS cord-010119-t1x9gknd 6839 14 or or CC cord-010119-t1x9gknd 6839 15 ceEK(var ceek(var ADD cord-010119-t1x9gknd 6839 16 ) ) -RRB- cord-010119-t1x9gknd 6840 1 or or CC cord-010119-t1x9gknd 6840 2 CeRN CeRN NNP cord-010119-t1x9gknd 6840 3 8/0 8/0 CD cord-010119-t1x9gknd 6840 4 8/0 8/0 CD cord-010119-t1x9gknd 6840 5 8/0 8/0 CD cord-010119-t1x9gknd 6841 1 ce48C,733 ce48C,733 : cord-010119-t1x9gknd 6841 2 G G NNP cord-010119-t1x9gknd 6841 3 1 1 CD cord-010119-t1x9gknd 6841 4 ce48C,712 ce48c,712 NN cord-010119-t1x9gknd 6841 5 G g NN cord-010119-t1x9gknd 6841 6 or or CC cord-010119-t1x9gknd 6841 7 ceMO cemo NN cord-010119-t1x9gknd 6841 8 or or CC cord-010119-t1x9gknd 6841 9 ceTI ceti NN cord-010119-t1x9gknd 6841 10 2/0 2/0 CD cord-010119-t1x9gknd 6841 11 2/0 2/0 CD cord-010119-t1x9gknd 6841 12 2/0 2/0 CD cord-010119-t1x9gknd 6841 13 ce48C,712G ce48C,712G NNS cord-010119-t1x9gknd 6841 14 / / NFP cord-010119-t1x9gknd 6841 15 ce254G/733 ce254G/733 NNP cord-010119-t1x9gknd 6841 16 G G NNP cord-010119-t1x9gknd 6841 17 ; ; : cord-010119-t1x9gknd 6841 18 ceS ceS NNP cord-010119-t1x9gknd 6841 19 / / SYM cord-010119-t1x9gknd 6841 20 ceTI ceti NN cord-010119-t1x9gknd 6841 21 ; ; : cord-010119-t1x9gknd 6841 22 ceAR ceAR NNP cord-010119-t1x9gknd 6841 23 / / SYM cord-010119-t1x9gknd 6841 24 ceEK ceEK NNP cord-010119-t1x9gknd 6841 25 ; ; : cord-010119-t1x9gknd 6841 26 ceEK ceEK NNP cord-010119-t1x9gknd 6841 27 / / SYM cord-010119-t1x9gknd 6841 28 ceJAL cejal RB cord-010119-t1x9gknd 6841 29 ; ; . cord-010119-t1x9gknd 6842 1 ceMO ceMO NNP cord-010119-t1x9gknd 6842 2 / / SYM cord-010119-t1x9gknd 6842 3 ceBI cebi NN cord-010119-t1x9gknd 6842 4 7/0 7/0 NNP cord-010119-t1x9gknd 6843 1 7/0 7/0 LS cord-010119-t1x9gknd 6843 2 7/0 7/0 CD cord-010119-t1x9gknd 6844 1 Total total JJ cord-010119-t1x9gknd 6844 2 106/8 106/8 CD cord-010119-t1x9gknd 6845 1 110/4 110/4 CD cord-010119-t1x9gknd 6846 1 113/2 113/2 CD cord-010119-t1x9gknd 6846 2 142A 142a CD cord-010119-t1x9gknd 6846 3 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 6846 4 2017 2017 CD cord-010119-t1x9gknd 6846 5 Vol Vol NNP cord-010119-t1x9gknd 6846 6 . . . cord-010119-t1x9gknd 6847 1 57 57 CD cord-010119-t1x9gknd 6847 2 Supplement supplement NN cord-010119-t1x9gknd 6847 3 S3 S3 NNP cord-010119-t1x9gknd 6847 4 reagents reagent NNS cord-010119-t1x9gknd 6847 5 should should MD cord-010119-t1x9gknd 6847 6 include include VB cord-010119-t1x9gknd 6847 7 an an DT cord-010119-t1x9gknd 6847 8 evaluation evaluation NN cord-010119-t1x9gknd 6847 9 of of IN cord-010119-t1x9gknd 6847 10 antigen antigen NN cord-010119-t1x9gknd 6847 11 variants variant NNS cord-010119-t1x9gknd 6847 12 to to TO cord-010119-t1x9gknd 6847 13 confirm confirm VB cord-010119-t1x9gknd 6847 14 fidelity fidelity NN cord-010119-t1x9gknd 6847 15 . . . cord-010119-t1x9gknd 6848 1 We -PRON- PRP cord-010119-t1x9gknd 6848 2 evaluated evaluate VBD cord-010119-t1x9gknd 6848 3 two two CD cord-010119-t1x9gknd 6848 4 monoclonal monoclonal JJ cord-010119-t1x9gknd 6848 5 anti anti NN cord-010119-t1x9gknd 6848 6 - - JJ cord-010119-t1x9gknd 6848 7 e e JJ cord-010119-t1x9gknd 6848 8 reagents reagent NNS cord-010119-t1x9gknd 6848 9 with with IN cord-010119-t1x9gknd 6848 10 comparator comparator NN cord-010119-t1x9gknd 6848 11 reagent reagent NN cord-010119-t1x9gknd 6848 12 using use VBG cord-010119-t1x9gknd 6848 13 a a DT cord-010119-t1x9gknd 6848 14 large large JJ cord-010119-t1x9gknd 6848 15 panel panel NN cord-010119-t1x9gknd 6848 16 of of IN cord-010119-t1x9gknd 6848 17 molecular molecular NN cord-010119-t1x9gknd 6848 18 confirmed confirm VBD cord-010119-t1x9gknd 6848 19 Rh Rh NNP cord-010119-t1x9gknd 6848 20 e e NN cord-010119-t1x9gknd 6848 21 variants variant NNS cord-010119-t1x9gknd 6848 22 . . . cord-010119-t1x9gknd 6849 1 Study Study NNP cord-010119-t1x9gknd 6849 2 Design Design NNP cord-010119-t1x9gknd 6849 3 / / SYM cord-010119-t1x9gknd 6849 4 Method method NN cord-010119-t1x9gknd 6849 5 : : : cord-010119-t1x9gknd 6849 6 Two two CD cord-010119-t1x9gknd 6849 7 monoclonal monoclonal JJ cord-010119-t1x9gknd 6849 8 anti anti NN cord-010119-t1x9gknd 6849 9 - - JJ cord-010119-t1x9gknd 6849 10 e e JJ cord-010119-t1x9gknd 6849 11 clones clone NNS cord-010119-t1x9gknd 6849 12 , , , cord-010119-t1x9gknd 6849 13 RD9/4 RD9/4 NNP cord-010119-t1x9gknd 6849 14 and and CC cord-010119-t1x9gknd 6849 15 RD12/2 RD12/2 NNP cord-010119-t1x9gknd 6849 16 , , , cord-010119-t1x9gknd 6849 17 and and CC cord-010119-t1x9gknd 6849 18 a a DT cord-010119-t1x9gknd 6849 19 licensed license VBN cord-010119-t1x9gknd 6849 20 comparator comparator NN cord-010119-t1x9gknd 6849 21 anti anti NN cord-010119-t1x9gknd 6849 22 - - NN cord-010119-t1x9gknd 6849 23 e e JJ cord-010119-t1x9gknd 6849 24 ( ( -LRB- cord-010119-t1x9gknd 6849 25 P3GD5121MS63 P3GD5121MS63 NNP cord-010119-t1x9gknd 6849 26 ) ) -RRB- cord-010119-t1x9gknd 6849 27 , , , cord-010119-t1x9gknd 6849 28 all all DT cord-010119-t1x9gknd 6849 29 from from IN cord-010119-t1x9gknd 6849 30 Diagast Diagast NNP cord-010119-t1x9gknd 6849 31 ( ( -LRB- cord-010119-t1x9gknd 6849 32 Loos Loos NNP cord-010119-t1x9gknd 6849 33 , , , cord-010119-t1x9gknd 6849 34 France France NNP cord-010119-t1x9gknd 6849 35 ) ) -RRB- cord-010119-t1x9gknd 6849 36 , , , cord-010119-t1x9gknd 6849 37 were be VBD cord-010119-t1x9gknd 6849 38 evaluated evaluate VBN cord-010119-t1x9gknd 6849 39 . . . cord-010119-t1x9gknd 6850 1 RBC RBC NNP cord-010119-t1x9gknd 6850 2 samples sample NNS cord-010119-t1x9gknd 6850 3 were be VBD cord-010119-t1x9gknd 6850 4 either either RB cord-010119-t1x9gknd 6850 5 recovered recover VBN cord-010119-t1x9gknd 6850 6 from from IN cord-010119-t1x9gknd 6850 7 frozen frozen JJ cord-010119-t1x9gknd 6850 8 storage storage NN cord-010119-t1x9gknd 6850 9 ( ( -LRB- cord-010119-t1x9gknd 6850 10 N N NNP cord-010119-t1x9gknd 6850 11 5 5 CD cord-010119-t1x9gknd 6850 12 42 42 CD cord-010119-t1x9gknd 6850 13 ) ) -RRB- cord-010119-t1x9gknd 6850 14 or or CC cord-010119-t1x9gknd 6850 15 EDTA EDTA NNP cord-010119-t1x9gknd 6850 16 blood blood NN cord-010119-t1x9gknd 6850 17 from from IN cord-010119-t1x9gknd 6850 18 donors donor NNS cord-010119-t1x9gknd 6850 19 ( ( -LRB- cord-010119-t1x9gknd 6850 20 N n CD cord-010119-t1x9gknd 6850 21 5 5 CD cord-010119-t1x9gknd 6850 22 72 72 CD cord-010119-t1x9gknd 6850 23 ) ) -RRB- cord-010119-t1x9gknd 6850 24 and and CC cord-010119-t1x9gknd 6850 25 were be VBD cord-010119-t1x9gknd 6850 26 tested test VBN cord-010119-t1x9gknd 6850 27 using use VBG cord-010119-t1x9gknd 6850 28 a a DT cord-010119-t1x9gknd 6850 29 manual manual JJ cord-010119-t1x9gknd 6850 30 tube tube NN cord-010119-t1x9gknd 6850 31 method method NN cord-010119-t1x9gknd 6850 32 or or CC cord-010119-t1x9gknd 6850 33 on on IN cord-010119-t1x9gknd 6850 34 a a DT cord-010119-t1x9gknd 6850 35 PK7300 PK7300 NNP cord-010119-t1x9gknd 6850 36 automated automate VBN cord-010119-t1x9gknd 6850 37 platform platform NN cord-010119-t1x9gknd 6850 38 . . . cord-010119-t1x9gknd 6851 1 A a DT cord-010119-t1x9gknd 6851 2 score score NN cord-010119-t1x9gknd 6851 3 6 6 CD cord-010119-t1x9gknd 6851 4 ( ( -LRB- cord-010119-t1x9gknd 6851 5 11 11 CD cord-010119-t1x9gknd 6851 6 ) ) -RRB- cord-010119-t1x9gknd 6851 7 or or CC cord-010119-t1x9gknd 6851 8 greater great JJR cord-010119-t1x9gknd 6851 9 was be VBD cord-010119-t1x9gknd 6851 10 deemed deem VBN cord-010119-t1x9gknd 6851 11 acceptable acceptable JJ cord-010119-t1x9gknd 6851 12 for for IN cord-010119-t1x9gknd 6851 13 manual manual JJ cord-010119-t1x9gknd 6851 14 tube tube NN cord-010119-t1x9gknd 6851 15 and and CC cord-010119-t1x9gknd 6851 16 a a DT cord-010119-t1x9gknd 6851 17 positive positive JJ cord-010119-t1x9gknd 6851 18 call call NN cord-010119-t1x9gknd 6851 19 for for IN cord-010119-t1x9gknd 6851 20 automated automated JJ cord-010119-t1x9gknd 6851 21 testing testing NN cord-010119-t1x9gknd 6851 22 . . . cord-010119-t1x9gknd 6852 1 Results result NNS cord-010119-t1x9gknd 6852 2 were be VBD cord-010119-t1x9gknd 6852 3 tabulated tabulate VBN cord-010119-t1x9gknd 6852 4 by by IN cord-010119-t1x9gknd 6852 5 complexity complexity NN cord-010119-t1x9gknd 6852 6 of of IN cord-010119-t1x9gknd 6852 7 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 6852 8 alleles allele NNS cord-010119-t1x9gknd 6852 9 ( ( -LRB- cord-010119-t1x9gknd 6852 10 Table table NN cord-010119-t1x9gknd 6852 11 1 1 CD cord-010119-t1x9gknd 6852 12 ) ) -RRB- cord-010119-t1x9gknd 6852 13 . . . cord-010119-t1x9gknd 6853 1 Results/ Results/ . cord-010119-t1x9gknd 6854 1 Finding finding NN cord-010119-t1x9gknd 6854 2 : : : cord-010119-t1x9gknd 6855 1 The the DT cord-010119-t1x9gknd 6855 2 specificity specificity NN cord-010119-t1x9gknd 6855 3 of of IN cord-010119-t1x9gknd 6855 4 the the DT cord-010119-t1x9gknd 6855 5 monoclonal monoclonal JJ cord-010119-t1x9gknd 6855 6 anti anti NN cord-010119-t1x9gknd 6855 7 - - NN cord-010119-t1x9gknd 6855 8 e e NNP cord-010119-t1x9gknd 6855 9 were be VBD cord-010119-t1x9gknd 6855 10 confirmed confirm VBN cord-010119-t1x9gknd 6855 11 using use VBG cord-010119-t1x9gknd 6855 12 common common JJ cord-010119-t1x9gknd 6855 13 Rhce Rhce NNP cord-010119-t1x9gknd 6855 14 haplotypes haplotype NNS cord-010119-t1x9gknd 6855 15 : : : cord-010119-t1x9gknd 6856 1 R r NN cord-010119-t1x9gknd 6856 2 1 1 CD cord-010119-t1x9gknd 6856 3 R r NN cord-010119-t1x9gknd 6856 4 1 1 CD cord-010119-t1x9gknd 6856 5 , , , cord-010119-t1x9gknd 6856 6 R r NN cord-010119-t1x9gknd 6856 7 2 2 CD cord-010119-t1x9gknd 6856 8 R r NN cord-010119-t1x9gknd 6856 9 2 2 CD cord-010119-t1x9gknd 6856 10 , , , cord-010119-t1x9gknd 6856 11 R r NN cord-010119-t1x9gknd 6856 12 1 1 CD cord-010119-t1x9gknd 6856 13 r r NN cord-010119-t1x9gknd 6856 14 , , , cord-010119-t1x9gknd 6856 15 and and CC cord-010119-t1x9gknd 6856 16 rr rr NNP cord-010119-t1x9gknd 6856 17 . . . cord-010119-t1x9gknd 6857 1 Twenty twenty CD cord-010119-t1x9gknd 6857 2 - - HYPH cord-010119-t1x9gknd 6857 3 one one CD cord-010119-t1x9gknd 6857 4 different different JJ cord-010119-t1x9gknd 6858 1 RHCE*ce rhce*ce IN cord-010119-t1x9gknd 6858 2 alleles allele NNS cord-010119-t1x9gknd 6858 3 were be VBD cord-010119-t1x9gknd 6858 4 included include VBN cord-010119-t1x9gknd 6858 5 in in IN cord-010119-t1x9gknd 6858 6 the the DT cord-010119-t1x9gknd 6858 7 extensive extensive JJ cord-010119-t1x9gknd 6858 8 panel panel NN cord-010119-t1x9gknd 6858 9 : : : cord-010119-t1x9gknd 6858 10 40 40 CD cord-010119-t1x9gknd 6858 11 were be VBD cord-010119-t1x9gknd 6858 12 RHCE*ce rhce*ce IN cord-010119-t1x9gknd 6858 13 that that DT cord-010119-t1x9gknd 6858 14 were be VBD cord-010119-t1x9gknd 6858 15 in in IN cord-010119-t1x9gknd 6858 16 trans trans NNP cord-010119-t1x9gknd 6858 17 to to IN cord-010119-t1x9gknd 6858 18 RHCE*cE RHCE*cE NNP cord-010119-t1x9gknd 6858 19 ; ; : cord-010119-t1x9gknd 6858 20 16 16 CD cord-010119-t1x9gknd 6858 21 were be VBD cord-010119-t1x9gknd 6858 22 various various JJ cord-010119-t1x9gknd 6858 23 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 6858 24 plus plus CC cord-010119-t1x9gknd 6858 25 RHCE*ce48C rhce*ce48c NN cord-010119-t1x9gknd 6858 26 compound compound NN cord-010119-t1x9gknd 6858 27 heterozygotes heterozygote NNS cord-010119-t1x9gknd 6858 28 ; ; : cord-010119-t1x9gknd 6858 29 31 31 CD cord-010119-t1x9gknd 6858 30 were be VBD cord-010119-t1x9gknd 6858 31 RHCE*ce rhce*ce JJ cord-010119-t1x9gknd 6858 32 or or CC cord-010119-t1x9gknd 6858 33 RHCE*Ce RHCE*Ce NNP cord-010119-t1x9gknd 6858 34 homozygotes homozygote NNS cord-010119-t1x9gknd 6858 35 ; ; : cord-010119-t1x9gknd 6858 36 27 27 CD cord-010119-t1x9gknd 6858 37 were be VBD cord-010119-t1x9gknd 6858 38 various various JJ cord-010119-t1x9gknd 6858 39 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 6858 40 and and CC cord-010119-t1x9gknd 6858 41 RHCE*Ce RHCE*Ce NNP cord-010119-t1x9gknd 6858 42 compound compound NN cord-010119-t1x9gknd 6858 43 heterozygotes heterozygote NNS cord-010119-t1x9gknd 6858 44 . . . cord-010119-t1x9gknd 6859 1 The the DT cord-010119-t1x9gknd 6859 2 comparator comparator NN cord-010119-t1x9gknd 6859 3 reagent reagent NN cord-010119-t1x9gknd 6859 4 was be VBD cord-010119-t1x9gknd 6859 5 negative negative JJ cord-010119-t1x9gknd 6859 6 or or CC cord-010119-t1x9gknd 6859 7 unacceptably unacceptably RB cord-010119-t1x9gknd 6859 8 weak weak JJ cord-010119-t1x9gknd 6859 9 for for IN cord-010119-t1x9gknd 6859 10 6 6 CD cord-010119-t1x9gknd 6859 11 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 6859 12 alleles allele NNS cord-010119-t1x9gknd 6859 13 in in IN cord-010119-t1x9gknd 6859 14 trans trans NNP cord-010119-t1x9gknd 6859 15 to to IN cord-010119-t1x9gknd 6859 16 RHCE*cE RHCE*cE NNP cord-010119-t1x9gknd 6859 17 ( ( -LRB- cord-010119-t1x9gknd 6859 18 RHCE*ceAR rhce*cear JJ cord-010119-t1x9gknd 6859 19 , , , cord-010119-t1x9gknd 6859 20 RHCE*ceMO RHCE*ceMO VBN cord-010119-t1x9gknd 6859 21 , , , cord-010119-t1x9gknd 6859 22 RHCE*-ceJAL RHCE*-ceJAL NNP cord-010119-t1x9gknd 6859 23 , , , cord-010119-t1x9gknd 6859 24 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6859 25 ) ) -RRB- cord-010119-t1x9gknd 6859 26 , , , cord-010119-t1x9gknd 6859 27 with with IN cord-010119-t1x9gknd 6859 28 1 1 CD cord-010119-t1x9gknd 6859 29 RHCE*ceAR rhce*cear JJ cord-010119-t1x9gknd 6859 30 / / SYM cord-010119-t1x9gknd 6859 31 RHCE*ce48C rhce*ce48c NN cord-010119-t1x9gknd 6859 32 compound compound NN cord-010119-t1x9gknd 6859 33 heterozygote heterozygote NN cord-010119-t1x9gknd 6859 34 , , , cord-010119-t1x9gknd 6859 35 and and CC cord-010119-t1x9gknd 6859 36 with with IN cord-010119-t1x9gknd 6859 37 1 1 CD cord-010119-t1x9gknd 6859 38 RHCE*ceCF RHCE*ceCF NNS cord-010119-t1x9gknd 6859 39 homozygote homozygote NN cord-010119-t1x9gknd 6859 40 . . . cord-010119-t1x9gknd 6860 1 RHCE*ceAR RHCE*ceAR NNP cord-010119-t1x9gknd 6860 2 , , , cord-010119-t1x9gknd 6860 3 RHCE*ceMO RHCE*ceMO VBN cord-010119-t1x9gknd 6860 4 , , , cord-010119-t1x9gknd 6860 5 RHCE*ceJAL rhce*cejal RB cord-010119-t1x9gknd 6860 6 , , , cord-010119-t1x9gknd 6860 7 and and CC cord-010119-t1x9gknd 6860 8 1 1 CD cord-010119-t1x9gknd 6860 9 of of IN cord-010119-t1x9gknd 6860 10 2 2 CD cord-010119-t1x9gknd 6860 11 RHCE*ceCF RHCE*ceCF NNS cord-010119-t1x9gknd 6860 12 homozygotes homozygote NNS cord-010119-t1x9gknd 6860 13 were be VBD cord-010119-t1x9gknd 6860 14 detected detect VBN cord-010119-t1x9gknd 6860 15 using use VBG cord-010119-t1x9gknd 6860 16 the the DT cord-010119-t1x9gknd 6860 17 comparator comparator NN cord-010119-t1x9gknd 6860 18 reagent reagent NN cord-010119-t1x9gknd 6860 19 . . . cord-010119-t1x9gknd 6861 1 RD9/4 RD9/4 NNP cord-010119-t1x9gknd 6861 2 and and CC cord-010119-t1x9gknd 6861 3 RD12/2 RD12/2 NNP cord-010119-t1x9gknd 6861 4 failed fail VBD cord-010119-t1x9gknd 6861 5 with with IN cord-010119-t1x9gknd 6861 6 4 4 CD cord-010119-t1x9gknd 6861 7 and and CC cord-010119-t1x9gknd 6861 8 1 1 CD cord-010119-t1x9gknd 6861 9 e e NN cord-010119-t1x9gknd 6861 10 variants variant NNS cord-010119-t1x9gknd 6861 11 , , , cord-010119-t1x9gknd 6861 12 respectively respectively RB cord-010119-t1x9gknd 6861 13 ( ( -LRB- cord-010119-t1x9gknd 6861 14 Table table NN cord-010119-t1x9gknd 6861 15 1 1 CD cord-010119-t1x9gknd 6861 16 ) ) -RRB- cord-010119-t1x9gknd 6861 17 . . . cord-010119-t1x9gknd 6862 1 Failure failure NN cord-010119-t1x9gknd 6862 2 to to TO cord-010119-t1x9gknd 6862 3 detect detect VB cord-010119-t1x9gknd 6862 4 the the DT cord-010119-t1x9gknd 6862 5 e e NN cord-010119-t1x9gknd 6862 6 variants variant NNS cord-010119-t1x9gknd 6862 7 was be VBD cord-010119-t1x9gknd 6862 8 observed observe VBN cord-010119-t1x9gknd 6862 9 using use VBG cord-010119-t1x9gknd 6862 10 both both CC cord-010119-t1x9gknd 6862 11 manual manual JJ cord-010119-t1x9gknd 6862 12 tube tube NN cord-010119-t1x9gknd 6862 13 and and CC cord-010119-t1x9gknd 6862 14 automated automate VBN cord-010119-t1x9gknd 6862 15 methods method NNS cord-010119-t1x9gknd 6862 16 for for IN cord-010119-t1x9gknd 6862 17 the the DT cord-010119-t1x9gknd 6862 18 comparator comparator NN cord-010119-t1x9gknd 6862 19 and and CC cord-010119-t1x9gknd 6862 20 the the DT cord-010119-t1x9gknd 6862 21 RD9/4 RD9/4 NNP cord-010119-t1x9gknd 6862 22 clone clone NN cord-010119-t1x9gknd 6862 23 . . . cord-010119-t1x9gknd 6863 1 None none NN cord-010119-t1x9gknd 6863 2 of of IN cord-010119-t1x9gknd 6863 3 the the DT cord-010119-t1x9gknd 6863 4 reagents reagent NNS cord-010119-t1x9gknd 6863 5 detected detect VBD cord-010119-t1x9gknd 6863 6 e e NN cord-010119-t1x9gknd 6863 7 antigen antigen NN cord-010119-t1x9gknd 6863 8 variant variant NN cord-010119-t1x9gknd 6863 9 expressed express VBN cord-010119-t1x9gknd 6863 10 on on IN cord-010119-t1x9gknd 6863 11 1 1 CD cord-010119-t1x9gknd 6863 12 example example NN cord-010119-t1x9gknd 6863 13 of of IN cord-010119-t1x9gknd 6863 14 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6864 1 /RHCE*cE. /RHCE*cE. . cord-010119-t1x9gknd 6864 2 Conclusion conclusion NN cord-010119-t1x9gknd 6864 3 : : : cord-010119-t1x9gknd 6864 4 RD9/4 RD9/4 NNP cord-010119-t1x9gknd 6864 5 and and CC cord-010119-t1x9gknd 6864 6 RD12/2 rd12/2 JJ cord-010119-t1x9gknd 6864 7 anti anti NN cord-010119-t1x9gknd 6864 8 - - NN cord-010119-t1x9gknd 6864 9 e e NN cord-010119-t1x9gknd 6864 10 reacted react VBD cord-010119-t1x9gknd 6864 11 with with IN cord-010119-t1x9gknd 6864 12 more more JJR cord-010119-t1x9gknd 6864 13 e e NN cord-010119-t1x9gknd 6864 14 variants variant NNS cord-010119-t1x9gknd 6864 15 than than IN cord-010119-t1x9gknd 6864 16 the the DT cord-010119-t1x9gknd 6864 17 comparator comparator NN cord-010119-t1x9gknd 6864 18 reagent reagent NN cord-010119-t1x9gknd 6864 19 . . . cord-010119-t1x9gknd 6865 1 The the DT cord-010119-t1x9gknd 6865 2 e e NN cord-010119-t1x9gknd 6865 3 antigen antigen NN cord-010119-t1x9gknd 6865 4 encoded encode VBN cord-010119-t1x9gknd 6865 5 by by IN cord-010119-t1x9gknd 6865 6 RHCE*JAL rhce*jal NN cord-010119-t1x9gknd 6865 7 and and CC cord-010119-t1x9gknd 6865 8 RHCE*AR rhce*ar NN cord-010119-t1x9gknd 6865 9 is be VBZ cord-010119-t1x9gknd 6865 10 not not RB cord-010119-t1x9gknd 6865 11 always always RB cord-010119-t1x9gknd 6865 12 detected detect VBN cord-010119-t1x9gknd 6865 13 when when WRB cord-010119-t1x9gknd 6865 14 in in IN cord-010119-t1x9gknd 6865 15 trans trans NNP cord-010119-t1x9gknd 6865 16 to to TO cord-010119-t1x9gknd 6865 17 RHCE*cE. RHCE*cE. NNP cord-010119-t1x9gknd 6866 1 However however RB cord-010119-t1x9gknd 6866 2 , , , cord-010119-t1x9gknd 6866 3 double double JJ cord-010119-t1x9gknd 6866 4 - - HYPH cord-010119-t1x9gknd 6866 5 dose dose NN cord-010119-t1x9gknd 6866 6 expression expression NN cord-010119-t1x9gknd 6866 7 was be VBD cord-010119-t1x9gknd 6866 8 detected detect VBN cord-010119-t1x9gknd 6866 9 suggesting suggest VBG cord-010119-t1x9gknd 6866 10 that that IN cord-010119-t1x9gknd 6866 11 the the DT cord-010119-t1x9gknd 6866 12 3 3 CD cord-010119-t1x9gknd 6866 13 monoclonal monoclonal JJ cord-010119-t1x9gknd 6866 14 reagents reagent NNS cord-010119-t1x9gknd 6866 15 bind bind VBP cord-010119-t1x9gknd 6866 16 weakly weakly RB cord-010119-t1x9gknd 6866 17 to to IN cord-010119-t1x9gknd 6866 18 the the DT cord-010119-t1x9gknd 6866 19 respective respective NNS cord-010119-t1x9gknd 6866 20 altered alter VBD cord-010119-t1x9gknd 6866 21 e e NN cord-010119-t1x9gknd 6866 22 antigen antigen NN cord-010119-t1x9gknd 6866 23 epitopes epitope NNS cord-010119-t1x9gknd 6866 24 . . . cord-010119-t1x9gknd 6867 1 The the DT cord-010119-t1x9gknd 6867 2 e e NN cord-010119-t1x9gknd 6867 3 antigen antigen NN cord-010119-t1x9gknd 6867 4 encoded encode VBN cord-010119-t1x9gknd 6867 5 by by IN cord-010119-t1x9gknd 6867 6 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6867 7 continues continue VBZ cord-010119-t1x9gknd 6867 8 to to TO cord-010119-t1x9gknd 6867 9 be be VB cord-010119-t1x9gknd 6867 10 a a DT cord-010119-t1x9gknd 6867 11 challenge challenge NN cord-010119-t1x9gknd 6867 12 to to TO cord-010119-t1x9gknd 6867 13 detect detect VB cord-010119-t1x9gknd 6867 14 . . . cord-010119-t1x9gknd 6868 1 Meihong Meihong NNP cord-010119-t1x9gknd 6868 2 Liu Liu NNP cord-010119-t1x9gknd 6868 3 * * NFP cord-010119-t1x9gknd 6868 4 , , , cord-010119-t1x9gknd 6868 5 Teresita Teresita NNP cord-010119-t1x9gknd 6868 6 Mercado Mercado NNP cord-010119-t1x9gknd 6868 7 , , , cord-010119-t1x9gknd 6868 8 Orieji Orieji NNP cord-010119-t1x9gknd 6868 9 Illoh Illoh NNP cord-010119-t1x9gknd 6868 10 , , , cord-010119-t1x9gknd 6868 11 Maria Maria NNP cord-010119-t1x9gknd 6868 12 Rios Rios NNP cord-010119-t1x9gknd 6868 13 and and CC cord-010119-t1x9gknd 6868 14 Zhugong Zhugong NNP cord-010119-t1x9gknd 6868 15 Liu Liu NNP cord-010119-t1x9gknd 6868 16 . . . cord-010119-t1x9gknd 6869 1 OBRR OBRR NNP cord-010119-t1x9gknd 6869 2 , , , cord-010119-t1x9gknd 6869 3 CBER CBER NNP cord-010119-t1x9gknd 6869 4 , , , cord-010119-t1x9gknd 6870 1 FDA FDA NNP cord-010119-t1x9gknd 6870 2 Background Background NNP cord-010119-t1x9gknd 6870 3 / / SYM cord-010119-t1x9gknd 6870 4 Case Case NNP cord-010119-t1x9gknd 6870 5 Studies Studies NNPS cord-010119-t1x9gknd 6870 6 : : : cord-010119-t1x9gknd 6870 7 Extended extend VBN cord-010119-t1x9gknd 6870 8 molecular molecular JJ cord-010119-t1x9gknd 6870 9 typing typing NN cord-010119-t1x9gknd 6870 10 of of IN cord-010119-t1x9gknd 6870 11 a a DT cord-010119-t1x9gknd 6870 12 large large JJ cord-010119-t1x9gknd 6870 13 number number NN cord-010119-t1x9gknd 6870 14 of of IN cord-010119-t1x9gknd 6870 15 blood blood NN cord-010119-t1x9gknd 6870 16 donors donor NNS cord-010119-t1x9gknd 6870 17 can can MD cord-010119-t1x9gknd 6870 18 increase increase VB cord-010119-t1x9gknd 6870 19 the the DT cord-010119-t1x9gknd 6870 20 likelihood likelihood NN cord-010119-t1x9gknd 6870 21 of of IN cord-010119-t1x9gknd 6870 22 identifying identify VBG cord-010119-t1x9gknd 6870 23 donor donor NN cord-010119-t1x9gknd 6870 24 red red JJ cord-010119-t1x9gknd 6870 25 blood blood NN cord-010119-t1x9gknd 6870 26 cells cell NNS cord-010119-t1x9gknd 6870 27 ( ( -LRB- cord-010119-t1x9gknd 6870 28 RBCs rbc NNS cord-010119-t1x9gknd 6870 29 ) ) -RRB- cord-010119-t1x9gknd 6870 30 that that WDT cord-010119-t1x9gknd 6870 31 match match VBP cord-010119-t1x9gknd 6870 32 those those DT cord-010119-t1x9gknd 6870 33 of of IN cord-010119-t1x9gknd 6870 34 the the DT cord-010119-t1x9gknd 6870 35 recipient recipient NN cord-010119-t1x9gknd 6870 36 . . . cord-010119-t1x9gknd 6871 1 This this DT cord-010119-t1x9gknd 6871 2 is be VBZ cord-010119-t1x9gknd 6871 3 especially especially RB cord-010119-t1x9gknd 6871 4 important important JJ cord-010119-t1x9gknd 6871 5 in in IN cord-010119-t1x9gknd 6871 6 the the DT cord-010119-t1x9gknd 6871 7 management management NN cord-010119-t1x9gknd 6871 8 of of IN cord-010119-t1x9gknd 6871 9 chronically chronically RB cord-010119-t1x9gknd 6871 10 - - HYPH cord-010119-t1x9gknd 6871 11 transfused transfuse VBN cord-010119-t1x9gknd 6871 12 patients patient NNS cord-010119-t1x9gknd 6871 13 and and CC cord-010119-t1x9gknd 6871 14 patients patient NNS cord-010119-t1x9gknd 6871 15 with with IN cord-010119-t1x9gknd 6871 16 RBC RBC NNP cord-010119-t1x9gknd 6871 17 alloantibodies alloantibody NNS cord-010119-t1x9gknd 6871 18 . . . cord-010119-t1x9gknd 6872 1 Several several JJ cord-010119-t1x9gknd 6872 2 high high JJ cord-010119-t1x9gknd 6872 3 - - HYPH cord-010119-t1x9gknd 6872 4 throughput throughput NN cord-010119-t1x9gknd 6872 5 multiplex multiplex JJ cord-010119-t1x9gknd 6872 6 blood blood NN cord-010119-t1x9gknd 6872 7 group group NN cord-010119-t1x9gknd 6872 8 molecular molecular JJ cord-010119-t1x9gknd 6872 9 typing typing NN cord-010119-t1x9gknd 6872 10 platforms platform NNS cord-010119-t1x9gknd 6872 11 have have VBP cord-010119-t1x9gknd 6872 12 been be VBN cord-010119-t1x9gknd 6872 13 developed develop VBN cord-010119-t1x9gknd 6872 14 to to TO cord-010119-t1x9gknd 6872 15 determine determine VB cord-010119-t1x9gknd 6872 16 blood blood NN cord-010119-t1x9gknd 6872 17 group group NN cord-010119-t1x9gknd 6872 18 antigen antigen NN cord-010119-t1x9gknd 6872 19 phenotypes phenotype NNS cord-010119-t1x9gknd 6872 20 . . . cord-010119-t1x9gknd 6873 1 Targeted target VBN cord-010119-t1x9gknd 6873 2 next next JJ cord-010119-t1x9gknd 6873 3 - - HYPH cord-010119-t1x9gknd 6873 4 generation generation NN cord-010119-t1x9gknd 6873 5 sequencing sequencing NN cord-010119-t1x9gknd 6873 6 ( ( -LRB- cord-010119-t1x9gknd 6873 7 NGS NGS NNP cord-010119-t1x9gknd 6873 8 ) ) -RRB- cord-010119-t1x9gknd 6873 9 provides provide VBZ cord-010119-t1x9gknd 6873 10 comprehensive comprehensive JJ cord-010119-t1x9gknd 6873 11 sequence sequence NN cord-010119-t1x9gknd 6873 12 information information NN cord-010119-t1x9gknd 6873 13 focusing focus VBG cord-010119-t1x9gknd 6873 14 on on IN cord-010119-t1x9gknd 6873 15 specified specify VBN cord-010119-t1x9gknd 6873 16 genomic genomic JJ cord-010119-t1x9gknd 6873 17 regions region NNS cord-010119-t1x9gknd 6873 18 , , , cord-010119-t1x9gknd 6873 19 and and CC cord-010119-t1x9gknd 6873 20 allows allow VBZ cord-010119-t1x9gknd 6873 21 the the DT cord-010119-t1x9gknd 6873 22 simultaneous simultaneous JJ cord-010119-t1x9gknd 6873 23 detection detection NN cord-010119-t1x9gknd 6873 24 of of IN cord-010119-t1x9gknd 6873 25 genetic genetic JJ cord-010119-t1x9gknd 6873 26 variants variant NNS cord-010119-t1x9gknd 6873 27 from from IN cord-010119-t1x9gknd 6873 28 multiple multiple JJ cord-010119-t1x9gknd 6873 29 genes gene NNS cord-010119-t1x9gknd 6873 30 in in IN cord-010119-t1x9gknd 6873 31 a a DT cord-010119-t1x9gknd 6873 32 large large JJ cord-010119-t1x9gknd 6873 33 number number NN cord-010119-t1x9gknd 6873 34 of of IN cord-010119-t1x9gknd 6873 35 samples sample NNS cord-010119-t1x9gknd 6873 36 . . . cord-010119-t1x9gknd 6874 1 We -PRON- PRP cord-010119-t1x9gknd 6874 2 developed develop VBD cord-010119-t1x9gknd 6874 3 and and CC cord-010119-t1x9gknd 6874 4 evaluated evaluate VBD cord-010119-t1x9gknd 6874 5 targeted target VBN cord-010119-t1x9gknd 6874 6 NGS NGS NNP cord-010119-t1x9gknd 6874 7 assays assay NNS cord-010119-t1x9gknd 6874 8 using use VBG cord-010119-t1x9gknd 6874 9 two two CD cord-010119-t1x9gknd 6874 10 different different JJ cord-010119-t1x9gknd 6874 11 target target NN cord-010119-t1x9gknd 6874 12 enrichment enrichment NN cord-010119-t1x9gknd 6874 13 platforms platform NNS cord-010119-t1x9gknd 6874 14 for for IN cord-010119-t1x9gknd 6874 15 extended extended JJ cord-010119-t1x9gknd 6874 16 blood blood NN cord-010119-t1x9gknd 6874 17 group group NN cord-010119-t1x9gknd 6874 18 genotyping genotyping NN cord-010119-t1x9gknd 6874 19 . . . cord-010119-t1x9gknd 6875 1 Study Study NNP cord-010119-t1x9gknd 6875 2 Design Design NNP cord-010119-t1x9gknd 6875 3 / / SYM cord-010119-t1x9gknd 6875 4 Method method NN cord-010119-t1x9gknd 6875 5 : : : cord-010119-t1x9gknd 6876 1 Two two CD cord-010119-t1x9gknd 6876 2 custom custom NN cord-010119-t1x9gknd 6876 3 design design NN cord-010119-t1x9gknd 6876 4 platforms platform NNS cord-010119-t1x9gknd 6876 5 SureSelect SureSelect NNP cord-010119-t1x9gknd 6876 6 and and CC cord-010119-t1x9gknd 6876 7 Halo Halo NNP cord-010119-t1x9gknd 6876 8 - - HYPH cord-010119-t1x9gknd 6876 9 Plex Plex NNP cord-010119-t1x9gknd 6876 10 were be VBD cord-010119-t1x9gknd 6876 11 used use VBN cord-010119-t1x9gknd 6876 12 independently independently RB cord-010119-t1x9gknd 6876 13 for for IN cord-010119-t1x9gknd 6876 14 preparation preparation NN cord-010119-t1x9gknd 6876 15 of of IN cord-010119-t1x9gknd 6876 16 probes probe NNS cord-010119-t1x9gknd 6876 17 that that WDT cord-010119-t1x9gknd 6876 18 target target VBP cord-010119-t1x9gknd 6876 19 the the DT cord-010119-t1x9gknd 6876 20 entire entire JJ cord-010119-t1x9gknd 6876 21 genes gene NNS cord-010119-t1x9gknd 6876 22 of of IN cord-010119-t1x9gknd 6876 23 19 19 CD cord-010119-t1x9gknd 6876 24 blood blood NN cord-010119-t1x9gknd 6876 25 group group NN cord-010119-t1x9gknd 6876 26 genes gene NNS cord-010119-t1x9gknd 6876 27 associated associate VBN cord-010119-t1x9gknd 6876 28 with with IN cord-010119-t1x9gknd 6876 29 the the DT cord-010119-t1x9gknd 6876 30 expression expression NN cord-010119-t1x9gknd 6876 31 of of IN cord-010119-t1x9gknd 6876 32 56 56 CD cord-010119-t1x9gknd 6876 33 blood blood NN cord-010119-t1x9gknd 6876 34 group group NN cord-010119-t1x9gknd 6876 35 antigens antigen NNS cord-010119-t1x9gknd 6876 36 from from IN cord-010119-t1x9gknd 6876 37 17 17 CD cord-010119-t1x9gknd 6876 38 blood blood NN cord-010119-t1x9gknd 6876 39 group group NN cord-010119-t1x9gknd 6876 40 systems system NNS cord-010119-t1x9gknd 6876 41 . . . cord-010119-t1x9gknd 6877 1 We -PRON- PRP cord-010119-t1x9gknd 6877 2 used use VBD cord-010119-t1x9gknd 6877 3 the the DT cord-010119-t1x9gknd 6877 4 Illumina Illumina NNP cord-010119-t1x9gknd 6877 5 's 's POS cord-010119-t1x9gknd 6877 6 HiSeq HiSeq NNP cord-010119-t1x9gknd 6877 7 2000/2500 2000/2500 CD cord-010119-t1x9gknd 6877 8 system system NN cord-010119-t1x9gknd 6877 9 to to TO cord-010119-t1x9gknd 6877 10 perform perform VB cord-010119-t1x9gknd 6877 11 next next JJ cord-010119-t1x9gknd 6877 12 generation generation NN cord-010119-t1x9gknd 6877 13 sequencing sequence VBG cord-010119-t1x9gknd 6877 14 first first RB cord-010119-t1x9gknd 6877 15 on on IN cord-010119-t1x9gknd 6877 16 SureSelect SureSelect NNP cord-010119-t1x9gknd 6877 17 - - HYPH cord-010119-t1x9gknd 6877 18 enriched enrich VBN cord-010119-t1x9gknd 6877 19 genes gene NNS cord-010119-t1x9gknd 6877 20 from from IN cord-010119-t1x9gknd 6877 21 16 16 CD cord-010119-t1x9gknd 6877 22 DNA dna NN cord-010119-t1x9gknd 6877 23 reference reference NN cord-010119-t1x9gknd 6877 24 samples sample NNS cord-010119-t1x9gknd 6877 25 with with IN cord-010119-t1x9gknd 6877 26 average average JJ cord-010119-t1x9gknd 6877 27 target target NN cord-010119-t1x9gknd 6877 28 design design NN cord-010119-t1x9gknd 6877 29 coverage coverage NN cord-010119-t1x9gknd 6877 30 of of IN cord-010119-t1x9gknd 6877 31 97.5 97.5 CD cord-010119-t1x9gknd 6877 32 % % NN cord-010119-t1x9gknd 6877 33 , , , cord-010119-t1x9gknd 6877 34 and and CC cord-010119-t1x9gknd 6877 35 then then RB cord-010119-t1x9gknd 6877 36 on on IN cord-010119-t1x9gknd 6877 37 HaloPlex HaloPlex NNP cord-010119-t1x9gknd 6877 38 - - HYPH cord-010119-t1x9gknd 6877 39 enriched enrich VBN cord-010119-t1x9gknd 6877 40 genes gene NNS cord-010119-t1x9gknd 6877 41 from from IN cord-010119-t1x9gknd 6877 42 32 32 CD cord-010119-t1x9gknd 6877 43 DNA dna NN cord-010119-t1x9gknd 6877 44 reference reference NN cord-010119-t1x9gknd 6877 45 samples sample NNS cord-010119-t1x9gknd 6877 46 with with IN cord-010119-t1x9gknd 6877 47 average average JJ cord-010119-t1x9gknd 6877 48 target target NN cord-010119-t1x9gknd 6877 49 design design NN cord-010119-t1x9gknd 6877 50 coverage coverage NN cord-010119-t1x9gknd 6877 51 above above IN cord-010119-t1x9gknd 6877 52 97.0 97.0 CD cord-010119-t1x9gknd 6877 53 % % NN cord-010119-t1x9gknd 6877 54 . . . cord-010119-t1x9gknd 6878 1 Twelve twelve CD cord-010119-t1x9gknd 6878 2 samples sample NNS cord-010119-t1x9gknd 6878 3 were be VBD cord-010119-t1x9gknd 6878 4 enriched enrich VBN cord-010119-t1x9gknd 6878 5 and and CC cord-010119-t1x9gknd 6878 6 sequenced sequence VBN cord-010119-t1x9gknd 6878 7 in in IN cord-010119-t1x9gknd 6878 8 both both DT cord-010119-t1x9gknd 6878 9 methods method NNS cord-010119-t1x9gknd 6878 10 to to TO cord-010119-t1x9gknd 6878 11 allow allow VB cord-010119-t1x9gknd 6878 12 a a DT cord-010119-t1x9gknd 6878 13 direct direct JJ cord-010119-t1x9gknd 6878 14 comparison comparison NN cord-010119-t1x9gknd 6878 15 . . . cord-010119-t1x9gknd 6879 1 All all DT cord-010119-t1x9gknd 6879 2 reference reference NN cord-010119-t1x9gknd 6879 3 samples sample NNS cord-010119-t1x9gknd 6879 4 were be VBD cord-010119-t1x9gknd 6879 5 previously previously RB cord-010119-t1x9gknd 6879 6 characterized characterize VBN cord-010119-t1x9gknd 6879 7 for for IN cord-010119-t1x9gknd 6879 8 38 38 CD cord-010119-t1x9gknd 6879 9 blood blood NN cord-010119-t1x9gknd 6879 10 group group NN cord-010119-t1x9gknd 6879 11 genetic genetic JJ cord-010119-t1x9gknd 6879 12 variants variant NNS cord-010119-t1x9gknd 6879 13 in in IN cord-010119-t1x9gknd 6879 14 these these DT cord-010119-t1x9gknd 6879 15 19 19 CD cord-010119-t1x9gknd 6879 16 genes gene NNS cord-010119-t1x9gknd 6879 17 using use VBG cord-010119-t1x9gknd 6879 18 TaqMan TaqMan NNP cord-010119-t1x9gknd 6879 19 SNP SNP NNP cord-010119-t1x9gknd 6879 20 assay assay NN cord-010119-t1x9gknd 6879 21 and and CC cord-010119-t1x9gknd 6879 22 Sanger Sanger NNP cord-010119-t1x9gknd 6879 23 Sequencing Sequencing NNP cord-010119-t1x9gknd 6879 24 assay assay NN cord-010119-t1x9gknd 6879 25 . . . cord-010119-t1x9gknd 6880 1 Serological serological JJ cord-010119-t1x9gknd 6880 2 data datum NNS cord-010119-t1x9gknd 6880 3 were be VBD cord-010119-t1x9gknd 6880 4 also also RB cord-010119-t1x9gknd 6880 5 available available JJ cord-010119-t1x9gknd 6880 6 for for IN cord-010119-t1x9gknd 6880 7 these these DT cord-010119-t1x9gknd 6880 8 samples sample NNS cord-010119-t1x9gknd 6880 9 . . . cord-010119-t1x9gknd 6881 1 The the DT cord-010119-t1x9gknd 6881 2 NGS NGS NNP cord-010119-t1x9gknd 6881 3 data datum NNS cord-010119-t1x9gknd 6881 4 were be VBD cord-010119-t1x9gknd 6881 5 analyzed analyze VBN cord-010119-t1x9gknd 6881 6 by by IN cord-010119-t1x9gknd 6881 7 CLC CLC NNP cord-010119-t1x9gknd 6881 8 Genomic Genomic NNP cord-010119-t1x9gknd 6881 9 Workbench Workbench NNP cord-010119-t1x9gknd 6881 10 . . . cord-010119-t1x9gknd 6882 1 Sequencing sequencing NN cord-010119-t1x9gknd 6882 2 variants variant NNS cord-010119-t1x9gknd 6882 3 were be VBD cord-010119-t1x9gknd 6882 4 detected detect VBN cord-010119-t1x9gknd 6882 5 and and CC cord-010119-t1x9gknd 6882 6 annotated annotate VBN cord-010119-t1x9gknd 6882 7 using use VBG cord-010119-t1x9gknd 6882 8 dbSNP dbSNP NNP cord-010119-t1x9gknd 6882 9 database database NN cord-010119-t1x9gknd 6882 10 . . . cord-010119-t1x9gknd 6883 1 Blood blood NN cord-010119-t1x9gknd 6883 2 group group NN cord-010119-t1x9gknd 6883 3 genotype genotype NN cord-010119-t1x9gknd 6883 4 calls call VBZ cord-010119-t1x9gknd 6883 5 by by IN cord-010119-t1x9gknd 6883 6 the the DT cord-010119-t1x9gknd 6883 7 two two CD cord-010119-t1x9gknd 6883 8 targeted target VBN cord-010119-t1x9gknd 6883 9 NGS NGS NNP cord-010119-t1x9gknd 6883 10 methods method NNS cord-010119-t1x9gknd 6883 11 were be VBD cord-010119-t1x9gknd 6883 12 compared compare VBN cord-010119-t1x9gknd 6883 13 with with IN cord-010119-t1x9gknd 6883 14 the the DT cord-010119-t1x9gknd 6883 15 reference reference NN cord-010119-t1x9gknd 6883 16 results result NNS cord-010119-t1x9gknd 6883 17 . . . cord-010119-t1x9gknd 6884 1 Results result NNS cord-010119-t1x9gknd 6884 2 / / SYM cord-010119-t1x9gknd 6884 3 Finding finding NN cord-010119-t1x9gknd 6884 4 : : : cord-010119-t1x9gknd 6884 5 For for IN cord-010119-t1x9gknd 6884 6 the the DT cord-010119-t1x9gknd 6884 7 two two CD cord-010119-t1x9gknd 6884 8 targeted target VBN cord-010119-t1x9gknd 6884 9 NGS NGS NNP cord-010119-t1x9gknd 6884 10 methods method NNS cord-010119-t1x9gknd 6884 11 , , , cord-010119-t1x9gknd 6884 12 we -PRON- PRP cord-010119-t1x9gknd 6884 13 evaluated evaluate VBD cord-010119-t1x9gknd 6884 14 and and CC cord-010119-t1x9gknd 6884 15 compared compare VBD cord-010119-t1x9gknd 6884 16 the the DT cord-010119-t1x9gknd 6884 17 target target NN cord-010119-t1x9gknd 6884 18 enrichment enrichment NN cord-010119-t1x9gknd 6884 19 efficiency efficiency NN cord-010119-t1x9gknd 6884 20 , , , cord-010119-t1x9gknd 6884 21 off off IN cord-010119-t1x9gknd 6884 22 - - HYPH cord-010119-t1x9gknd 6884 23 target target NN cord-010119-t1x9gknd 6884 24 enrichment enrichment NN cord-010119-t1x9gknd 6884 25 , , , cord-010119-t1x9gknd 6884 26 quality quality NN cord-010119-t1x9gknd 6884 27 of of IN cord-010119-t1x9gknd 6884 28 NGS NGS NNP cord-010119-t1x9gknd 6884 29 , , , cord-010119-t1x9gknd 6884 30 sequencing sequencing NN cord-010119-t1x9gknd 6884 31 coverage coverage NN cord-010119-t1x9gknd 6884 32 , , , cord-010119-t1x9gknd 6884 33 and and CC cord-010119-t1x9gknd 6884 34 genotype genotype NN cord-010119-t1x9gknd 6884 35 concordance concordance NN cord-010119-t1x9gknd 6884 36 . . . cord-010119-t1x9gknd 6885 1 A a DT cord-010119-t1x9gknd 6885 2 higher high JJR cord-010119-t1x9gknd 6885 3 percentage percentage NN cord-010119-t1x9gknd 6885 4 of of IN cord-010119-t1x9gknd 6885 5 the the DT cord-010119-t1x9gknd 6885 6 HaloPlex HaloPlex NNP cord-010119-t1x9gknd 6885 7 reads read VBZ cord-010119-t1x9gknd 6885 8 ( ( -LRB- cord-010119-t1x9gknd 6885 9 80.54 80.54 CD cord-010119-t1x9gknd 6885 10 % % NN cord-010119-t1x9gknd 6885 11 ) ) -RRB- cord-010119-t1x9gknd 6885 12 were be VBD cord-010119-t1x9gknd 6885 13 mapped map VBN cord-010119-t1x9gknd 6885 14 to to IN cord-010119-t1x9gknd 6885 15 the the DT cord-010119-t1x9gknd 6885 16 target target NN cord-010119-t1x9gknd 6885 17 regions region NNS cord-010119-t1x9gknd 6885 18 relative relative JJ cord-010119-t1x9gknd 6885 19 to to IN cord-010119-t1x9gknd 6885 20 the the DT cord-010119-t1x9gknd 6885 21 SureSelect SureSelect NNP cord-010119-t1x9gknd 6885 22 reads read VBZ cord-010119-t1x9gknd 6885 23 ( ( -LRB- cord-010119-t1x9gknd 6885 24 29.23 29.23 CD cord-010119-t1x9gknd 6885 25 % % NN cord-010119-t1x9gknd 6885 26 ) ) -RRB- cord-010119-t1x9gknd 6885 27 . . . cord-010119-t1x9gknd 6886 1 The the DT cord-010119-t1x9gknd 6886 2 mean mean JJ cord-010119-t1x9gknd 6886 3 sequence sequence NN cord-010119-t1x9gknd 6886 4 coverage coverage NN cord-010119-t1x9gknd 6886 5 depth depth NN cord-010119-t1x9gknd 6886 6 of of IN cord-010119-t1x9gknd 6886 7 the the DT cord-010119-t1x9gknd 6886 8 targeted target VBN cord-010119-t1x9gknd 6886 9 bases basis NNS cord-010119-t1x9gknd 6886 10 was be VBD cord-010119-t1x9gknd 6886 11 around around RB cord-010119-t1x9gknd 6886 12 200x 200x CD cord-010119-t1x9gknd 6886 13 for for IN cord-010119-t1x9gknd 6886 14 SureSelect SureSelect NNP cord-010119-t1x9gknd 6886 15 method method NN cord-010119-t1x9gknd 6886 16 and and CC cord-010119-t1x9gknd 6886 17 300x 300x NNPS cord-010119-t1x9gknd 6886 18 for for IN cord-010119-t1x9gknd 6886 19 HaloPlex HaloPlex NNP cord-010119-t1x9gknd 6886 20 method method NN cord-010119-t1x9gknd 6886 21 . . . cord-010119-t1x9gknd 6887 1 Some some DT cord-010119-t1x9gknd 6887 2 exons exon NNS cord-010119-t1x9gknd 6887 3 , , , cord-010119-t1x9gknd 6887 4 such such JJ cord-010119-t1x9gknd 6887 5 as as IN cord-010119-t1x9gknd 6887 6 RHD RHD NNP cord-010119-t1x9gknd 6887 7 exons exon NNS cord-010119-t1x9gknd 6887 8 4 4 CD cord-010119-t1x9gknd 6887 9 and and CC cord-010119-t1x9gknd 6887 10 8 8 CD cord-010119-t1x9gknd 6887 11 , , , cord-010119-t1x9gknd 6887 12 10 10 CD cord-010119-t1x9gknd 6887 13 , , , cord-010119-t1x9gknd 6887 14 RHCE RHCE NNP cord-010119-t1x9gknd 6887 15 exon exon NN cord-010119-t1x9gknd 6887 16 10 10 CD cord-010119-t1x9gknd 6887 17 , , , cord-010119-t1x9gknd 6887 18 ERMAP ERMAP NNP cord-010119-t1x9gknd 6887 19 exons exon NNS cord-010119-t1x9gknd 6887 20 5 5 CD cord-010119-t1x9gknd 6887 21 and and CC cord-010119-t1x9gknd 6887 22 12 12 CD cord-010119-t1x9gknd 6887 23 , , , cord-010119-t1x9gknd 6887 24 CD55 CD55 NNP cord-010119-t1x9gknd 6887 25 exons exon NNS cord-010119-t1x9gknd 6887 26 10 10 CD cord-010119-t1x9gknd 6887 27 and and CC cord-010119-t1x9gknd 6887 28 11 11 CD cord-010119-t1x9gknd 6887 29 , , , cord-010119-t1x9gknd 6887 30 CR1 CR1 NNP cord-010119-t1x9gknd 6887 31 gene gene NN cord-010119-t1x9gknd 6887 32 ( ( -LRB- cord-010119-t1x9gknd 6887 33 most most JJS cord-010119-t1x9gknd 6887 34 exons exon NNS cord-010119-t1x9gknd 6887 35 ) ) -RRB- cord-010119-t1x9gknd 6887 36 and and CC cord-010119-t1x9gknd 6887 37 GYPB GYPB NNP cord-010119-t1x9gknd 6887 38 exon exon NN cord-010119-t1x9gknd 6887 39 5 5 CD cord-010119-t1x9gknd 6887 40 , , , cord-010119-t1x9gknd 6887 41 are be VBP cord-010119-t1x9gknd 6887 42 consistently consistently RB cord-010119-t1x9gknd 6887 43 covered cover VBN cord-010119-t1x9gknd 6887 44 with with IN cord-010119-t1x9gknd 6887 45 less less JJR cord-010119-t1x9gknd 6887 46 than than IN cord-010119-t1x9gknd 6887 47 10x 10x CD cord-010119-t1x9gknd 6887 48 coverage coverage NN cord-010119-t1x9gknd 6887 49 by by IN cord-010119-t1x9gknd 6887 50 both both CC cord-010119-t1x9gknd 6887 51 SureSelect SureSelect NNP cord-010119-t1x9gknd 6887 52 and and CC cord-010119-t1x9gknd 6887 53 HaloPlex HaloPlex NNP cord-010119-t1x9gknd 6887 54 targeted target VBD cord-010119-t1x9gknd 6887 55 NGS NGS NNP cord-010119-t1x9gknd 6887 56 methods method NNS cord-010119-t1x9gknd 6887 57 . . . cord-010119-t1x9gknd 6888 1 Both both DT cord-010119-t1x9gknd 6888 2 methods method NNS cord-010119-t1x9gknd 6888 3 detected detect VBD cord-010119-t1x9gknd 6888 4 RHD RHD NNP cord-010119-t1x9gknd 6888 5 gene gene NN cord-010119-t1x9gknd 6888 6 deletion deletion NN cord-010119-t1x9gknd 6888 7 in in IN cord-010119-t1x9gknd 6888 8 a a DT cord-010119-t1x9gknd 6888 9 few few JJ cord-010119-t1x9gknd 6888 10 representative representative JJ cord-010119-t1x9gknd 6888 11 samples sample NNS cord-010119-t1x9gknd 6888 12 . . . cord-010119-t1x9gknd 6889 1 The the DT cord-010119-t1x9gknd 6889 2 genotype genotype NN cord-010119-t1x9gknd 6889 3 call call NN cord-010119-t1x9gknd 6889 4 concordance concordance NN cord-010119-t1x9gknd 6889 5 on on IN cord-010119-t1x9gknd 6889 6 38 38 CD cord-010119-t1x9gknd 6889 7 blood blood NN cord-010119-t1x9gknd 6889 8 group group NN cord-010119-t1x9gknd 6889 9 genetic genetic JJ cord-010119-t1x9gknd 6889 10 variants variant NNS cord-010119-t1x9gknd 6889 11 was be VBD cord-010119-t1x9gknd 6889 12 assessed assess VBN cord-010119-t1x9gknd 6889 13 by by IN cord-010119-t1x9gknd 6889 14 comparing compare VBG cord-010119-t1x9gknd 6889 15 NGS NGS NNP cord-010119-t1x9gknd 6889 16 results result NNS cord-010119-t1x9gknd 6889 17 to to IN cord-010119-t1x9gknd 6889 18 TaqMan TaqMan NNP cord-010119-t1x9gknd 6889 19 genotyping genotype VBG cord-010119-t1x9gknd 6889 20 and and CC cord-010119-t1x9gknd 6889 21 Sanger Sanger NNP cord-010119-t1x9gknd 6889 22 sequencing sequencing NN cord-010119-t1x9gknd 6889 23 results result NNS cord-010119-t1x9gknd 6889 24 , , , cord-010119-t1x9gknd 6889 25 and and CC cord-010119-t1x9gknd 6889 26 more more JJR cord-010119-t1x9gknd 6889 27 than than IN cord-010119-t1x9gknd 6889 28 90 90 CD cord-010119-t1x9gknd 6889 29 % % NN cord-010119-t1x9gknd 6889 30 concordance concordance NN cord-010119-t1x9gknd 6889 31 was be VBD cord-010119-t1x9gknd 6889 32 obtained obtain VBN cord-010119-t1x9gknd 6889 33 for for IN cord-010119-t1x9gknd 6889 34 both both DT cord-010119-t1x9gknd 6889 35 targeted target VBN cord-010119-t1x9gknd 6889 36 NGS NGS NNP cord-010119-t1x9gknd 6889 37 methods method NNS cord-010119-t1x9gknd 6889 38 . . . cord-010119-t1x9gknd 6890 1 Incorrect incorrect JJ cord-010119-t1x9gknd 6890 2 calls call NNS cord-010119-t1x9gknd 6890 3 were be VBD cord-010119-t1x9gknd 6890 4 restricted restrict VBN cord-010119-t1x9gknd 6890 5 to to IN cord-010119-t1x9gknd 6890 6 four four CD cord-010119-t1x9gknd 6890 7 complex complex JJ cord-010119-t1x9gknd 6890 8 blood blood NN cord-010119-t1x9gknd 6890 9 group group NN cord-010119-t1x9gknd 6890 10 genes gene NNS cord-010119-t1x9gknd 6890 11 : : : cord-010119-t1x9gknd 6890 12 MNS MNS NNP cord-010119-t1x9gknd 6890 13 , , , cord-010119-t1x9gknd 6890 14 RHD RHD NNP cord-010119-t1x9gknd 6890 15 , , , cord-010119-t1x9gknd 6890 16 RHCE RHCE NNP cord-010119-t1x9gknd 6890 17 and and CC cord-010119-t1x9gknd 6890 18 ABO ABO NNP cord-010119-t1x9gknd 6890 19 , , , cord-010119-t1x9gknd 6890 20 and and CC cord-010119-t1x9gknd 6890 21 involved involve VBN cord-010119-t1x9gknd 6890 22 mainly mainly RB cord-010119-t1x9gknd 6890 23 heterozygous heterozygous JJ cord-010119-t1x9gknd 6890 24 variants variant NNS cord-010119-t1x9gknd 6890 25 and and CC cord-010119-t1x9gknd 6890 26 indels indel NNS cord-010119-t1x9gknd 6890 27 . . . cord-010119-t1x9gknd 6891 1 Conclusion conclusion NN cord-010119-t1x9gknd 6891 2 : : : cord-010119-t1x9gknd 6892 1 Using use VBG cord-010119-t1x9gknd 6892 2 two two CD cord-010119-t1x9gknd 6892 3 targeted target VBN cord-010119-t1x9gknd 6892 4 NGS NGS NNP cord-010119-t1x9gknd 6892 5 methods method NNS cord-010119-t1x9gknd 6892 6 , , , cord-010119-t1x9gknd 6892 7 we -PRON- PRP cord-010119-t1x9gknd 6892 8 have have VBP cord-010119-t1x9gknd 6892 9 correctly correctly RB cord-010119-t1x9gknd 6892 10 detected detect VBN cord-010119-t1x9gknd 6892 11 more more JJR cord-010119-t1x9gknd 6892 12 than than IN cord-010119-t1x9gknd 6892 13 90 90 CD cord-010119-t1x9gknd 6892 14 % % NN cord-010119-t1x9gknd 6892 15 blood blood NN cord-010119-t1x9gknd 6892 16 group group NN cord-010119-t1x9gknd 6892 17 genetic genetic JJ cord-010119-t1x9gknd 6892 18 variants variant NNS cord-010119-t1x9gknd 6892 19 in in IN cord-010119-t1x9gknd 6892 20 19 19 CD cord-010119-t1x9gknd 6892 21 selected select VBN cord-010119-t1x9gknd 6892 22 genes gene NNS cord-010119-t1x9gknd 6892 23 . . . cord-010119-t1x9gknd 6893 1 Evidence evidence NN cord-010119-t1x9gknd 6893 2 RHCE*ceHAR rhce*cehar JJ cord-010119-t1x9gknd 6894 1 Does do VBZ cord-010119-t1x9gknd 6894 2 Not not RB cord-010119-t1x9gknd 6894 3 Encode encode VB cord-010119-t1x9gknd 6894 4 for for IN cord-010119-t1x9gknd 6895 1 Rh34 Rh34 NNP cord-010119-t1x9gknd 6895 2 ( ( -LRB- cord-010119-t1x9gknd 6895 3 Hr Hr NNP cord-010119-t1x9gknd 6895 4 B B NNP cord-010119-t1x9gknd 6895 5 ) ) -RRB- cord-010119-t1x9gknd 6895 6 Antigen Antigen NNP cord-010119-t1x9gknd 6895 7 Debra Debra NNP cord-010119-t1x9gknd 6895 8 J J NNP cord-010119-t1x9gknd 6895 9 Bailey Bailey NNP cord-010119-t1x9gknd 6895 10 * * NFP cord-010119-t1x9gknd 6895 11 1 1 CD cord-010119-t1x9gknd 6895 12 , , , cord-010119-t1x9gknd 6895 13 Trina Trina NNP cord-010119-t1x9gknd 6895 14 Horn Horn NNP cord-010119-t1x9gknd 6895 15 2 2 CD cord-010119-t1x9gknd 6895 16 , , , cord-010119-t1x9gknd 6895 17 Paul Paul NNP cord-010119-t1x9gknd 6895 18 Mansfield Mansfield NNP cord-010119-t1x9gknd 6895 19 2 2 CD cord-010119-t1x9gknd 6895 20 , , , cord-010119-t1x9gknd 6895 21 Najmi Najmi NNP cord-010119-t1x9gknd 6895 22 Qazi Qazi NNP cord-010119-t1x9gknd 6895 23 1 1 CD cord-010119-t1x9gknd 6895 24 , , , cord-010119-t1x9gknd 6895 25 Pamela Pamela NNP cord-010119-t1x9gknd 6895 26 Nickle Nickle NNP cord-010119-t1x9gknd 6895 27 2 2 CD cord-010119-t1x9gknd 6895 28 , , , cord-010119-t1x9gknd 6895 29 Jessica Jessica NNP cord-010119-t1x9gknd 6895 30 Keller Keller NNP cord-010119-t1x9gknd 6895 31 2 2 CD cord-010119-t1x9gknd 6895 32 , , , cord-010119-t1x9gknd 6895 33 Margaret Margaret NNP cord-010119-t1x9gknd 6895 34 A A NNP cord-010119-t1x9gknd 6895 35 Keller Keller NNP cord-010119-t1x9gknd 6895 36 2 2 CD cord-010119-t1x9gknd 6895 37 and and CC cord-010119-t1x9gknd 6895 38 Jan Jan NNP cord-010119-t1x9gknd 6895 39 R R NNP cord-010119-t1x9gknd 6895 40 Hamilton Hamilton NNP cord-010119-t1x9gknd 6895 41 1 1 CD cord-010119-t1x9gknd 6895 42 . . . cord-010119-t1x9gknd 6896 1 Background Background NNP cord-010119-t1x9gknd 6896 2 / / SYM cord-010119-t1x9gknd 6896 3 Case Case NNP cord-010119-t1x9gknd 6896 4 Studies Studies NNPS cord-010119-t1x9gknd 6897 1 : : : cord-010119-t1x9gknd 6897 2 The the DT cord-010119-t1x9gknd 6897 3 RHCE RHCE NNP cord-010119-t1x9gknd 6897 4 gene gene NN cord-010119-t1x9gknd 6897 5 has have VBZ cord-010119-t1x9gknd 6897 6 many many JJ cord-010119-t1x9gknd 6897 7 variant variant JJ cord-010119-t1x9gknd 6897 8 forms form NNS cord-010119-t1x9gknd 6897 9 , , , cord-010119-t1x9gknd 6897 10 yet yet CC cord-010119-t1x9gknd 6897 11 for for IN cord-010119-t1x9gknd 6897 12 many many JJ cord-010119-t1x9gknd 6897 13 , , , cord-010119-t1x9gknd 6897 14 the the DT cord-010119-t1x9gknd 6897 15 phenotypes phenotype NNS cord-010119-t1x9gknd 6897 16 encoded encode VBN cord-010119-t1x9gknd 6897 17 by by IN cord-010119-t1x9gknd 6897 18 these these DT cord-010119-t1x9gknd 6897 19 variant variant JJ cord-010119-t1x9gknd 6897 20 alleles allele NNS cord-010119-t1x9gknd 6897 21 is be VBZ cord-010119-t1x9gknd 6897 22 unknown unknown JJ cord-010119-t1x9gknd 6897 23 or or CC cord-010119-t1x9gknd 6897 24 incomplete incomplete JJ cord-010119-t1x9gknd 6897 25 . . . cord-010119-t1x9gknd 6898 1 New new JJ cord-010119-t1x9gknd 6898 2 information information NN cord-010119-t1x9gknd 6898 3 can can MD cord-010119-t1x9gknd 6898 4 be be VB cord-010119-t1x9gknd 6898 5 elucidated elucidate VBN cord-010119-t1x9gknd 6898 6 when when WRB cord-010119-t1x9gknd 6898 7 two two CD cord-010119-t1x9gknd 6898 8 altered alter VBN cord-010119-t1x9gknd 6898 9 alleles allele NNS cord-010119-t1x9gknd 6898 10 or or CC cord-010119-t1x9gknd 6898 11 haplotypes haplotype NNS cord-010119-t1x9gknd 6898 12 are be VBP cord-010119-t1x9gknd 6898 13 expressed express VBN cord-010119-t1x9gknd 6898 14 in in IN cord-010119-t1x9gknd 6898 15 an an DT cord-010119-t1x9gknd 6898 16 individual individual NN cord-010119-t1x9gknd 6898 17 with with IN cord-010119-t1x9gknd 6898 18 subsequent subsequent JJ cord-010119-t1x9gknd 6898 19 alloantibody alloantibody NN cord-010119-t1x9gknd 6898 20 formation formation NN cord-010119-t1x9gknd 6898 21 . . . cord-010119-t1x9gknd 6899 1 The the DT cord-010119-t1x9gknd 6899 2 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6899 3 allele allele NN cord-010119-t1x9gknd 6899 4 was be VBD cord-010119-t1x9gknd 6899 5 first first RB cord-010119-t1x9gknd 6899 6 described describe VBN cord-010119-t1x9gknd 6899 7 in in IN cord-010119-t1x9gknd 6899 8 1996 1996 CD cord-010119-t1x9gknd 6899 9 and and CC cord-010119-t1x9gknd 6899 10 has have VBZ cord-010119-t1x9gknd 6899 11 a a DT cord-010119-t1x9gknd 6899 12 phenotype phenotype NN cord-010119-t1x9gknd 6899 13 of of IN cord-010119-t1x9gknd 6899 14 C2E2c1e1 C2E2c1e1 NNP cord-010119-t1x9gknd 6899 15 w w NNP cord-010119-t1x9gknd 6899 16 f1 f1 NNP cord-010119-t1x9gknd 6899 17 w w NNP cord-010119-t1x9gknd 6899 18 , , , cord-010119-t1x9gknd 6899 19 G2 G2 NNP cord-010119-t1x9gknd 6899 20 , , , cord-010119-t1x9gknd 6899 21 Hr Hr NNP cord-010119-t1x9gknd 6899 22 0 0 CD cord-010119-t1x9gknd 6899 23 1 1 CD cord-010119-t1x9gknd 6899 24 w w NN cord-010119-t1x9gknd 6899 25 , , , cord-010119-t1x9gknd 6899 26 Hr2 hr2 CD cord-010119-t1x9gknd 6899 27 , , , cord-010119-t1x9gknd 6899 28 hr hr NNP cord-010119-t1x9gknd 6899 29 S S NNP cord-010119-t1x9gknd 6899 30 2 2 CD cord-010119-t1x9gknd 6899 31 , , , cord-010119-t1x9gknd 6899 32 Rh:33 Rh:33 NNP cord-010119-t1x9gknd 6899 33 , , , cord-010119-t1x9gknd 6899 34 Rh:50 Rh:50 NNP cord-010119-t1x9gknd 6899 35 with with IN cord-010119-t1x9gknd 6899 36 a a DT cord-010119-t1x9gknd 6899 37 partial partial JJ cord-010119-t1x9gknd 6899 38 D d NN cord-010119-t1x9gknd 6899 39 antigen antigen NN cord-010119-t1x9gknd 6899 40 expression expression NN cord-010119-t1x9gknd 6899 41 . . . cord-010119-t1x9gknd 6900 1 We -PRON- PRP cord-010119-t1x9gknd 6900 2 describe describe VBP cord-010119-t1x9gknd 6900 3 new new JJ cord-010119-t1x9gknd 6900 4 information information NN cord-010119-t1x9gknd 6900 5 regarding regard VBG cord-010119-t1x9gknd 6900 6 an an DT cord-010119-t1x9gknd 6900 7 RH RH NNP cord-010119-t1x9gknd 6900 8 haplotype haplotype NN cord-010119-t1x9gknd 6900 9 that that WDT cord-010119-t1x9gknd 6900 10 includes include VBZ cord-010119-t1x9gknd 6900 11 an an DT cord-010119-t1x9gknd 6900 12 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6900 13 allele allele NN cord-010119-t1x9gknd 6900 14 and and CC cord-010119-t1x9gknd 6900 15 its -PRON- PRP$ cord-010119-t1x9gknd 6900 16 apparent apparent JJ cord-010119-t1x9gknd 6900 17 Rh:234 rh:234 NN cord-010119-t1x9gknd 6900 18 ( ( -LRB- cord-010119-t1x9gknd 6900 19 Hr hr NN cord-010119-t1x9gknd 6900 20 B b NN cord-010119-t1x9gknd 6900 21 2 2 CD cord-010119-t1x9gknd 6900 22 ) ) -RRB- cord-010119-t1x9gknd 6900 23 expression expression NN cord-010119-t1x9gknd 6900 24 . . . cord-010119-t1x9gknd 6901 1 Study Study NNP cord-010119-t1x9gknd 6901 2 Design Design NNP cord-010119-t1x9gknd 6901 3 / / SYM cord-010119-t1x9gknd 6901 4 Method method NN cord-010119-t1x9gknd 6901 5 : : : cord-010119-t1x9gknd 6902 1 RBC RBC NNP cord-010119-t1x9gknd 6902 2 typing typing NN cord-010119-t1x9gknd 6902 3 was be VBD cord-010119-t1x9gknd 6902 4 performed perform VBN cord-010119-t1x9gknd 6902 5 by by IN cord-010119-t1x9gknd 6902 6 standard standard JJ cord-010119-t1x9gknd 6902 7 tube tube NN cord-010119-t1x9gknd 6902 8 methods method NNS cord-010119-t1x9gknd 6902 9 with with IN cord-010119-t1x9gknd 6902 10 polyclonal polyclonal JJ cord-010119-t1x9gknd 6902 11 and and CC cord-010119-t1x9gknd 6902 12 monoclonal monoclonal JJ cord-010119-t1x9gknd 6902 13 antisera antisera NN cord-010119-t1x9gknd 6902 14 . . . cord-010119-t1x9gknd 6903 1 Antibody antibody NN cord-010119-t1x9gknd 6903 2 identification identification NN cord-010119-t1x9gknd 6903 3 studies study NNS cord-010119-t1x9gknd 6903 4 were be VBD cord-010119-t1x9gknd 6903 5 performed perform VBN cord-010119-t1x9gknd 6903 6 by by IN cord-010119-t1x9gknd 6903 7 standard standard JJ cord-010119-t1x9gknd 6903 8 tube tube NN cord-010119-t1x9gknd 6903 9 hemagglutination hemagglutination NN cord-010119-t1x9gknd 6903 10 methods method NNS cord-010119-t1x9gknd 6903 11 by by IN cord-010119-t1x9gknd 6903 12 published publish VBN cord-010119-t1x9gknd 6903 13 techniques technique NNS cord-010119-t1x9gknd 6903 14 . . . cord-010119-t1x9gknd 6904 1 Molecular molecular JJ cord-010119-t1x9gknd 6904 2 immunohematology immunohematology NN cord-010119-t1x9gknd 6904 3 testing testing NN cord-010119-t1x9gknd 6904 4 was be VBD cord-010119-t1x9gknd 6904 5 performed perform VBN cord-010119-t1x9gknd 6904 6 on on IN cord-010119-t1x9gknd 6904 7 genomic genomic JJ cord-010119-t1x9gknd 6904 8 DNA dna NN cord-010119-t1x9gknd 6904 9 extracted extract VBN cord-010119-t1x9gknd 6904 10 from from IN cord-010119-t1x9gknd 6904 11 whole whole JJ cord-010119-t1x9gknd 6904 12 blood blood NN cord-010119-t1x9gknd 6904 13 and and CC cord-010119-t1x9gknd 6904 14 included include VBD cord-010119-t1x9gknd 6904 15 HEA HEA NNP cord-010119-t1x9gknd 6904 16 , , , cord-010119-t1x9gknd 6904 17 RHD RHD NNP cord-010119-t1x9gknd 6904 18 and and CC cord-010119-t1x9gknd 6904 19 RHCE RHCE NNP cord-010119-t1x9gknd 6904 20 BeadChips BeadChips NNP cord-010119-t1x9gknd 6904 21 ( ( -LRB- cord-010119-t1x9gknd 6904 22 Immucor Immucor NNP cord-010119-t1x9gknd 6904 23 ) ) -RRB- cord-010119-t1x9gknd 6904 24 and and CC cord-010119-t1x9gknd 6904 25 PCR PCR NNP cord-010119-t1x9gknd 6904 26 - - HYPH cord-010119-t1x9gknd 6904 27 RFLP RFLP NNP cord-010119-t1x9gknd 6904 28 analysis analysis NN cord-010119-t1x9gknd 6904 29 for for IN cord-010119-t1x9gknd 6904 30 RHCE RHCE NNP cord-010119-t1x9gknd 6904 31 c.254C c.254C NNP cord-010119-t1x9gknd 6905 1 > > XX cord-010119-t1x9gknd 6906 1 G G NNP cord-010119-t1x9gknd 6906 2 and and CC cord-010119-t1x9gknd 6906 3 RHD RHD NNP cord-010119-t1x9gknd 6906 4 c.1136C c.1136C NNP cord-010119-t1x9gknd 6907 1 > > XX cord-010119-t1x9gknd 6908 1 T. t. NN cord-010119-t1x9gknd 6908 2 Results/ Results/ NNP cord-010119-t1x9gknd 6909 1 Finding finding NN cord-010119-t1x9gknd 6909 2 : : : cord-010119-t1x9gknd 6910 1 A a DT cord-010119-t1x9gknd 6910 2 sample sample NN cord-010119-t1x9gknd 6910 3 from from IN cord-010119-t1x9gknd 6910 4 an an DT cord-010119-t1x9gknd 6910 5 African african JJ cord-010119-t1x9gknd 6910 6 American american JJ cord-010119-t1x9gknd 6910 7 female female NN cord-010119-t1x9gknd 6910 8 with with IN cord-010119-t1x9gknd 6910 9 a a DT cord-010119-t1x9gknd 6910 10 history history NN cord-010119-t1x9gknd 6910 11 of of IN cord-010119-t1x9gknd 6910 12 an an DT cord-010119-t1x9gknd 6910 13 anti anti JJ cord-010119-t1x9gknd 6910 14 - - JJ cord-010119-t1x9gknd 6910 15 E e JJ cord-010119-t1x9gknd 6910 16 and and CC cord-010119-t1x9gknd 6910 17 anti anti JJ cord-010119-t1x9gknd 6910 18 - - NNP cord-010119-t1x9gknd 6910 19 K K NNP cord-010119-t1x9gknd 6910 20 was be VBD cord-010119-t1x9gknd 6910 21 evaluated evaluate VBN cord-010119-t1x9gknd 6910 22 for for IN cord-010119-t1x9gknd 6910 23 unexpected unexpected JJ cord-010119-t1x9gknd 6910 24 antibodies antibody NNS cord-010119-t1x9gknd 6910 25 . . . cord-010119-t1x9gknd 6911 1 Her -PRON- PRP$ cord-010119-t1x9gknd 6911 2 red red JJ cord-010119-t1x9gknd 6911 3 cell cell NN cord-010119-t1x9gknd 6911 4 serologic serologic NN cord-010119-t1x9gknd 6912 1 Rh Rh NNP cord-010119-t1x9gknd 6912 2 phenotype phenotype NN cord-010119-t1x9gknd 6912 3 on on IN cord-010119-t1x9gknd 6912 4 an an DT cord-010119-t1x9gknd 6912 5 untransfused untransfused JJ cord-010119-t1x9gknd 6912 6 sample sample NN cord-010119-t1x9gknd 6912 7 was be VBD cord-010119-t1x9gknd 6912 8 D1C1E2c1e1 D1C1E2c1e1 NNP cord-010119-t1x9gknd 6912 9 . . . cord-010119-t1x9gknd 6913 1 Her -PRON- PRP$ cord-010119-t1x9gknd 6913 2 plasma plasma NN cord-010119-t1x9gknd 6913 3 contained contain VBD cord-010119-t1x9gknd 6913 4 an an DT cord-010119-t1x9gknd 6913 5 alloanti alloanti NNP cord-010119-t1x9gknd 6913 6 - - HYPH cord-010119-t1x9gknd 6913 7 S s NN cord-010119-t1x9gknd 6913 8 and and CC cord-010119-t1x9gknd 6913 9 an an DT cord-010119-t1x9gknd 6913 10 antibody antibody NN cord-010119-t1x9gknd 6913 11 that that WDT cord-010119-t1x9gknd 6913 12 reacted react VBD cord-010119-t1x9gknd 6913 13 strongly strongly RB cord-010119-t1x9gknd 6913 14 with with IN cord-010119-t1x9gknd 6913 15 all all DT cord-010119-t1x9gknd 6913 16 random random JJ cord-010119-t1x9gknd 6913 17 E2K2S2 e2k2s2 NN cord-010119-t1x9gknd 6913 18 reagent reagent NN cord-010119-t1x9gknd 6913 19 red red JJ cord-010119-t1x9gknd 6913 20 cells cell NNS cord-010119-t1x9gknd 6913 21 except except IN cord-010119-t1x9gknd 6913 22 her -PRON- PRP$ cord-010119-t1x9gknd 6913 23 own own JJ cord-010119-t1x9gknd 6913 24 . . . cord-010119-t1x9gknd 6914 1 The the DT cord-010119-t1x9gknd 6914 2 unidentified unidentified JJ cord-010119-t1x9gknd 6914 3 reactivity reactivity NN cord-010119-t1x9gknd 6914 4 persisted persist VBD cord-010119-t1x9gknd 6914 5 following follow VBG cord-010119-t1x9gknd 6914 6 ficin ficin NNS cord-010119-t1x9gknd 6914 7 and and CC cord-010119-t1x9gknd 6914 8 DTT DTT NNP cord-010119-t1x9gknd 6914 9 pretreatment pretreatment NN cord-010119-t1x9gknd 6914 10 of of IN cord-010119-t1x9gknd 6914 11 reagent reagent JJ cord-010119-t1x9gknd 6914 12 red red JJ cord-010119-t1x9gknd 6914 13 cells cell NNS cord-010119-t1x9gknd 6914 14 . . . cord-010119-t1x9gknd 6915 1 Only only RB cord-010119-t1x9gknd 6915 2 D22 D22 NNP cord-010119-t1x9gknd 6915 3 and and CC cord-010119-t1x9gknd 6915 4 Dc2 dc2 NN cord-010119-t1x9gknd 6915 5 red red JJ cord-010119-t1x9gknd 6915 6 cells cell NNS cord-010119-t1x9gknd 6915 7 were be VBD cord-010119-t1x9gknd 6915 8 non non JJ cord-010119-t1x9gknd 6915 9 - - JJ cord-010119-t1x9gknd 6915 10 reactive reactive JJ cord-010119-t1x9gknd 6915 11 in in IN cord-010119-t1x9gknd 6915 12 initial initial JJ cord-010119-t1x9gknd 6915 13 tests test NNS cord-010119-t1x9gknd 6915 14 . . . cord-010119-t1x9gknd 6916 1 Differential differential JJ cord-010119-t1x9gknd 6916 2 adsorption adsorption NN cord-010119-t1x9gknd 6916 3 studies study NNS cord-010119-t1x9gknd 6916 4 excluded exclude VBD cord-010119-t1x9gknd 6916 5 antibodies antibody NNS cord-010119-t1x9gknd 6916 6 to to IN cord-010119-t1x9gknd 6916 7 all all DT cord-010119-t1x9gknd 6916 8 other other JJ cord-010119-t1x9gknd 6916 9 common common JJ cord-010119-t1x9gknd 6916 10 antigens antigen NNS cord-010119-t1x9gknd 6916 11 and and CC cord-010119-t1x9gknd 6916 12 hr hr NN cord-010119-t1x9gknd 6916 13 B b NN cord-010119-t1x9gknd 6916 14 except except IN cord-010119-t1x9gknd 6916 15 E E NNP cord-010119-t1x9gknd 6916 16 , , , cord-010119-t1x9gknd 6916 17 S S NNP cord-010119-t1x9gknd 6916 18 and and CC cord-010119-t1x9gknd 6916 19 K. K. NNP cord-010119-t1x9gknd 6917 1 When when WRB cord-010119-t1x9gknd 6917 2 subsequent subsequent JJ cord-010119-t1x9gknd 6917 3 examples example NNS cord-010119-t1x9gknd 6917 4 of of IN cord-010119-t1x9gknd 6917 5 E2S2K2 E2S2K2 NNP cord-010119-t1x9gknd 6917 6 red red NNP cord-010119-t1x9gknd 6917 7 cells cell NNS cord-010119-t1x9gknd 6917 8 homozygous homozygous JJ cord-010119-t1x9gknd 6917 9 for for IN cord-010119-t1x9gknd 6917 10 the the DT cord-010119-t1x9gknd 6917 11 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 6917 12 - - HYPH cord-010119-t1x9gknd 6917 13 CE(4 ce(4 NN cord-010119-t1x9gknd 6917 14 - - HYPH cord-010119-t1x9gknd 6917 15 7)-D 7)-D NNP cord-010119-t1x9gknd 6917 16 , , , cord-010119-t1x9gknd 6917 17 RHCE*-ce48C,733G,1006 RHCE*-ce48C,733G,1006 NNP cord-010119-t1x9gknd 6917 18 T T NNP cord-010119-t1x9gknd 6917 19 haplotype haplotype NN cord-010119-t1x9gknd 6917 20 ( ( -LRB- cord-010119-t1x9gknd 6917 21 i.e. i.e. FW cord-010119-t1x9gknd 6917 22 , , , cord-010119-t1x9gknd 6917 23 r r FW cord-010119-t1x9gknd 6917 24 ' ' '' cord-010119-t1x9gknd 6917 25 S s NN cord-010119-t1x9gknd 6917 26 /r /r . cord-010119-t1x9gknd 6917 27 ' ' '' cord-010119-t1x9gknd 6917 28 S S NNP cord-010119-t1x9gknd 6917 29 ) ) -RRB- cord-010119-t1x9gknd 6917 30 and and CC cord-010119-t1x9gknd 6917 31 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 6917 32 , , , cord-010119-t1x9gknd 6917 33 RHCE*-ce48C,733G,1006T/ RHCE*-ce48C,733G,1006T/ NNP cord-010119-t1x9gknd 6917 34 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 6917 35 - - HYPH cord-010119-t1x9gknd 6917 36 CE(4 ce(4 NN cord-010119-t1x9gknd 6917 37 - - HYPH cord-010119-t1x9gknd 6917 38 7)-D 7)-D NNP cord-010119-t1x9gknd 6917 39 , , , cord-010119-t1x9gknd 6917 40 RHCE*ce48C,733G,1006 RHCE*ce48C,733G,1006 NNP cord-010119-t1x9gknd 6917 41 T T NNP cord-010119-t1x9gknd 6917 42 ( ( -LRB- cord-010119-t1x9gknd 6917 43 i.e. i.e. FW cord-010119-t1x9gknd 6917 44 , , , cord-010119-t1x9gknd 6917 45 Bastiaan Bastiaan NNP cord-010119-t1x9gknd 6917 46 genotype genotype NN cord-010119-t1x9gknd 6917 47 ) ) -RRB- cord-010119-t1x9gknd 6917 48 were be VBD cord-010119-t1x9gknd 6917 49 found find VBN cord-010119-t1x9gknd 6917 50 to to TO cord-010119-t1x9gknd 6917 51 be be VB cord-010119-t1x9gknd 6917 52 non non JJ cord-010119-t1x9gknd 6917 53 - - JJ cord-010119-t1x9gknd 6917 54 reactive reactive JJ cord-010119-t1x9gknd 6917 55 with with IN cord-010119-t1x9gknd 6917 56 the the DT cord-010119-t1x9gknd 6917 57 patient patient NN cord-010119-t1x9gknd 6917 58 's 's POS cord-010119-t1x9gknd 6917 59 plasma plasma NN cord-010119-t1x9gknd 6917 60 , , , cord-010119-t1x9gknd 6917 61 the the DT cord-010119-t1x9gknd 6917 62 antibody antibody NN cord-010119-t1x9gknd 6917 63 specificity specificity NN cord-010119-t1x9gknd 6917 64 was be VBD cord-010119-t1x9gknd 6917 65 determined determine VBN cord-010119-t1x9gknd 6917 66 to to TO cord-010119-t1x9gknd 6917 67 be be VB cord-010119-t1x9gknd 6917 68 anti anti JJ cord-010119-t1x9gknd 6917 69 - - JJ cord-010119-t1x9gknd 6917 70 Hr Hr NNP cord-010119-t1x9gknd 6917 71 B b NN cord-010119-t1x9gknd 6917 72 . . . cord-010119-t1x9gknd 6918 1 The the DT cord-010119-t1x9gknd 6918 2 patient patient NN cord-010119-t1x9gknd 6918 3 's 's POS cord-010119-t1x9gknd 6918 4 red red JJ cord-010119-t1x9gknd 6918 5 cell cell NN cord-010119-t1x9gknd 6918 6 antigen antigen NN cord-010119-t1x9gknd 6918 7 genotype genotype NN cord-010119-t1x9gknd 6918 8 identified identify VBD cord-010119-t1x9gknd 6918 9 the the DT cord-010119-t1x9gknd 6918 10 following follow VBG cord-010119-t1x9gknd 6918 11 probable probable JJ cord-010119-t1x9gknd 6918 12 RH RH NNP cord-010119-t1x9gknd 6918 13 haplotypes haplotype NNS cord-010119-t1x9gknd 6918 14 : : : cord-010119-t1x9gknd 6919 1 RHD*01 RHD*01 NNP cord-010119-t1x9gknd 6919 2 , , , cord-010119-t1x9gknd 6919 3 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6919 4 and and CC cord-010119-t1x9gknd 6919 5 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 6919 6 - - HYPH cord-010119-t1x9gknd 6919 7 CE(4 ce(4 NN cord-010119-t1x9gknd 6919 8 - - HYPH cord-010119-t1x9gknd 6919 9 7)-D 7)-D NNP cord-010119-t1x9gknd 6919 10 , , , cord-010119-t1x9gknd 6919 11 RHCE*ce48C,733G,1006T. RHCE*ce48C,733G,1006T. : cord-010119-t1x9gknd 6919 12 Additional additional JJ cord-010119-t1x9gknd 6919 13 antigen antigen NN cord-010119-t1x9gknd 6919 14 typing typing NN cord-010119-t1x9gknd 6919 15 of of IN cord-010119-t1x9gknd 6919 16 the the DT cord-010119-t1x9gknd 6919 17 patient patient NN cord-010119-t1x9gknd 6919 18 's 's POS cord-010119-t1x9gknd 6919 19 red red JJ cord-010119-t1x9gknd 6919 20 cells cell NNS cord-010119-t1x9gknd 6919 21 with with IN cord-010119-t1x9gknd 6919 22 unlicensed unlicensed JJ cord-010119-t1x9gknd 6919 23 antisera antisera NN cord-010119-t1x9gknd 6919 24 indicated indicate VBD cord-010119-t1x9gknd 6919 25 an an DT cord-010119-t1x9gknd 6919 26 Hr1 hr1 NN cord-010119-t1x9gknd 6919 27 ( ( -LRB- cord-010119-t1x9gknd 6919 28 2 2 CD cord-010119-t1x9gknd 6919 29 of of IN cord-010119-t1x9gknd 6919 30 2 2 CD cord-010119-t1x9gknd 6919 31 sources source NNS cord-010119-t1x9gknd 6919 32 ) ) -RRB- cord-010119-t1x9gknd 6919 33 and and CC cord-010119-t1x9gknd 6919 34 Hr Hr NNP cord-010119-t1x9gknd 6919 35 B B NNP cord-010119-t1x9gknd 6919 36 2 2 CD cord-010119-t1x9gknd 6919 37 ( ( -LRB- cord-010119-t1x9gknd 6919 38 2 2 CD cord-010119-t1x9gknd 6919 39 of of IN cord-010119-t1x9gknd 6919 40 3 3 CD cord-010119-t1x9gknd 6919 41 sources source NNS cord-010119-t1x9gknd 6919 42 ) ) -RRB- cord-010119-t1x9gknd 6919 43 phenotype phenotype NN cord-010119-t1x9gknd 6919 44 . . . cord-010119-t1x9gknd 6920 1 Conclusion conclusion NN cord-010119-t1x9gknd 6920 2 : : : cord-010119-t1x9gknd 6921 1 The the DT cord-010119-t1x9gknd 6921 2 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 6921 3 - - HYPH cord-010119-t1x9gknd 6921 4 CE(4 ce(4 NN cord-010119-t1x9gknd 6921 5 - - HYPH cord-010119-t1x9gknd 6921 6 7)-D 7)-D NNP cord-010119-t1x9gknd 6921 7 , , , cord-010119-t1x9gknd 6921 8 RHCE*ce48C,733G,1006 RHCE*ce48C,733G,1006 NNP cord-010119-t1x9gknd 6921 9 T T NNP cord-010119-t1x9gknd 6921 10 haplotype haplotype NN cord-010119-t1x9gknd 6921 11 is be VBZ cord-010119-t1x9gknd 6921 12 one one CD cord-010119-t1x9gknd 6921 13 of of IN cord-010119-t1x9gknd 6921 14 the the DT cord-010119-t1x9gknd 6921 15 RH RH NNP cord-010119-t1x9gknd 6921 16 haplotypes haplotype NNS cord-010119-t1x9gknd 6921 17 expressed express VBN cord-010119-t1x9gknd 6921 18 by by IN cord-010119-t1x9gknd 6921 19 the the DT cord-010119-t1x9gknd 6921 20 original original JJ cord-010119-t1x9gknd 6921 21 Hr hr NN cord-010119-t1x9gknd 6921 22 B b NN cord-010119-t1x9gknd 6921 23 2 2 CD cord-010119-t1x9gknd 6921 24 individual individual JJ cord-010119-t1x9gknd 6921 25 Bastiaan Bastiaan NNP cord-010119-t1x9gknd 6921 26 . . . cord-010119-t1x9gknd 6922 1 The the DT cord-010119-t1x9gknd 6922 2 Hr Hr NNP cord-010119-t1x9gknd 6922 3 B b NN cord-010119-t1x9gknd 6922 4 antigen antigen NN cord-010119-t1x9gknd 6922 5 status status NN cord-010119-t1x9gknd 6922 6 of of IN cord-010119-t1x9gknd 6922 7 red red JJ cord-010119-t1x9gknd 6922 8 cells cell NNS cord-010119-t1x9gknd 6922 9 of of IN cord-010119-t1x9gknd 6922 10 individuals individual NNS cord-010119-t1x9gknd 6922 11 with with IN cord-010119-t1x9gknd 6922 12 the the DT cord-010119-t1x9gknd 6922 13 RHCE*-ceHAR RHCE*-ceHAR NNP cord-010119-t1x9gknd 6922 14 allele allele NN cord-010119-t1x9gknd 6922 15 has have VBZ cord-010119-t1x9gknd 6922 16 not not RB cord-010119-t1x9gknd 6922 17 been be VBN cord-010119-t1x9gknd 6922 18 described describe VBN cord-010119-t1x9gknd 6922 19 . . . cord-010119-t1x9gknd 6923 1 We -PRON- PRP cord-010119-t1x9gknd 6923 2 report report VBP cord-010119-t1x9gknd 6923 3 an an DT cord-010119-t1x9gknd 6923 4 individual individual NN cord-010119-t1x9gknd 6923 5 with with IN cord-010119-t1x9gknd 6923 6 the the DT cord-010119-t1x9gknd 6923 7 probable probable JJ cord-010119-t1x9gknd 6923 8 RHD*01 rhd*01 NN cord-010119-t1x9gknd 6923 9 , , , cord-010119-t1x9gknd 6923 10 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6923 11 and and CC cord-010119-t1x9gknd 6923 12 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 6923 13 - - HYPH cord-010119-t1x9gknd 6923 14 CE(4 ce(4 NN cord-010119-t1x9gknd 6923 15 - - HYPH cord-010119-t1x9gknd 6923 16 7)-D 7)-D NNP cord-010119-t1x9gknd 6923 17 , , , cord-010119-t1x9gknd 6923 18 RHCE*ce48C,733G,1006 RHCE*ce48C,733G,1006 NNP cord-010119-t1x9gknd 6923 19 T T NNP cord-010119-t1x9gknd 6923 20 RH RH NNP cord-010119-t1x9gknd 6923 21 haplotypes haplotype NNS cord-010119-t1x9gknd 6923 22 and and CC cord-010119-t1x9gknd 6923 23 production production NN cord-010119-t1x9gknd 6923 24 of of IN cord-010119-t1x9gknd 6923 25 alloanti alloanti NNP cord-010119-t1x9gknd 6923 26 - - HYPH cord-010119-t1x9gknd 6923 27 Hr Hr NNP cord-010119-t1x9gknd 6923 28 B B NNP cord-010119-t1x9gknd 6923 29 . . . cord-010119-t1x9gknd 6924 1 The the DT cord-010119-t1x9gknd 6924 2 specificity specificity NN cord-010119-t1x9gknd 6924 3 of of IN cord-010119-t1x9gknd 6924 4 the the DT cord-010119-t1x9gknd 6924 5 alloantibody alloantibody NN cord-010119-t1x9gknd 6924 6 produced produce VBN cord-010119-t1x9gknd 6924 7 and and CC cord-010119-t1x9gknd 6924 8 the the DT cord-010119-t1x9gknd 6924 9 red red JJ cord-010119-t1x9gknd 6924 10 cell cell NN cord-010119-t1x9gknd 6924 11 Hr Hr NNP cord-010119-t1x9gknd 6924 12 B B NNP cord-010119-t1x9gknd 6924 13 serologic serologic NN cord-010119-t1x9gknd 6924 14 antigen antigen NN cord-010119-t1x9gknd 6924 15 type type NN cord-010119-t1x9gknd 6924 16 supports support VBZ cord-010119-t1x9gknd 6924 17 the the DT cord-010119-t1x9gknd 6924 18 conclusion conclusion NN cord-010119-t1x9gknd 6924 19 the the DT cord-010119-t1x9gknd 6924 20 variant variant JJ cord-010119-t1x9gknd 6924 21 allele allele NN cord-010119-t1x9gknd 6924 22 RHCE*ceHAR rhce*cehar NN cord-010119-t1x9gknd 6924 23 does do VBZ cord-010119-t1x9gknd 6924 24 not not RB cord-010119-t1x9gknd 6924 25 encode encode VB cord-010119-t1x9gknd 6924 26 for for IN cord-010119-t1x9gknd 6924 27 the the DT cord-010119-t1x9gknd 6924 28 Hr Hr NNP cord-010119-t1x9gknd 6924 29 B B NNP cord-010119-t1x9gknd 6924 30 antigen antigen NN cord-010119-t1x9gknd 6924 31 . . . cord-010119-t1x9gknd 6925 1 Excluding exclude VBG cord-010119-t1x9gknd 6925 2 Clinically clinically RB cord-010119-t1x9gknd 6925 3 Significant significant JJ cord-010119-t1x9gknd 6925 4 Alloantibodies Alloantibodies NNPS cord-010119-t1x9gknd 6925 5 in in IN cord-010119-t1x9gknd 6925 6 the the DT cord-010119-t1x9gknd 6925 7 Presence Presence NNP cord-010119-t1x9gknd 6925 8 of of IN cord-010119-t1x9gknd 6925 9 Interfering Interfering NNP cord-010119-t1x9gknd 6925 10 Antibodies Antibodies NNP cord-010119-t1x9gknd 6925 11 with with IN cord-010119-t1x9gknd 6925 12 High High NNP cord-010119-t1x9gknd 6925 13 - - HYPH cord-010119-t1x9gknd 6925 14 Titer Titer NNP cord-010119-t1x9gknd 6925 15 , , , cord-010119-t1x9gknd 6925 16 Low low JJ cord-010119-t1x9gknd 6925 17 - - HYPH cord-010119-t1x9gknd 6925 18 Avidity Avidity NNP cord-010119-t1x9gknd 6925 19 Characteristics characteristic NNS cord-010119-t1x9gknd 6925 20 . . . cord-010119-t1x9gknd 6926 1 Background Background NNP cord-010119-t1x9gknd 6926 2 / / SYM cord-010119-t1x9gknd 6926 3 Case Case NNP cord-010119-t1x9gknd 6926 4 Studies Studies NNPS cord-010119-t1x9gknd 6926 5 : : : cord-010119-t1x9gknd 6926 6 High high JJ cord-010119-t1x9gknd 6926 7 - - HYPH cord-010119-t1x9gknd 6926 8 titer titer NN cord-010119-t1x9gknd 6926 9 , , , cord-010119-t1x9gknd 6926 10 low low JJ cord-010119-t1x9gknd 6926 11 - - HYPH cord-010119-t1x9gknd 6926 12 avidity avidity NN cord-010119-t1x9gknd 6926 13 antibodies antibody NNS cord-010119-t1x9gknd 6926 14 ( ( -LRB- cord-010119-t1x9gknd 6926 15 HTLA HTLA NNP cord-010119-t1x9gknd 6926 16 ) ) -RRB- cord-010119-t1x9gknd 6926 17 are be VBP cord-010119-t1x9gknd 6926 18 a a DT cord-010119-t1x9gknd 6926 19 group group NN cord-010119-t1x9gknd 6926 20 of of IN cord-010119-t1x9gknd 6926 21 clinically clinically RB cord-010119-t1x9gknd 6926 22 insignificant insignificant JJ cord-010119-t1x9gknd 6926 23 antibodies antibody NNS cord-010119-t1x9gknd 6926 24 ( ( -LRB- cord-010119-t1x9gknd 6926 25 AB AB NNP cord-010119-t1x9gknd 6926 26 ) ) -RRB- cord-010119-t1x9gknd 6926 27 directed direct VBN cord-010119-t1x9gknd 6926 28 against against IN cord-010119-t1x9gknd 6926 29 highprevalence highprevalence NNP cord-010119-t1x9gknd 6926 30 red red JJ cord-010119-t1x9gknd 6926 31 cell cell NN cord-010119-t1x9gknd 6926 32 antigens antigen NNS cord-010119-t1x9gknd 6926 33 . . . cord-010119-t1x9gknd 6927 1 They -PRON- PRP cord-010119-t1x9gknd 6927 2 interfere interfere VBP cord-010119-t1x9gknd 6927 3 with with IN cord-010119-t1x9gknd 6927 4 the the DT cord-010119-t1x9gknd 6927 5 exclusion exclusion NN cord-010119-t1x9gknd 6927 6 of of IN cord-010119-t1x9gknd 6927 7 clinically clinically RB cord-010119-t1x9gknd 6927 8 significant significant JJ cord-010119-t1x9gknd 6927 9 red red JJ cord-010119-t1x9gknd 6927 10 cell cell NN cord-010119-t1x9gknd 6927 11 AB ab NN cord-010119-t1x9gknd 6927 12 and and CC cord-010119-t1x9gknd 6927 13 crossmatch crossmatch NN cord-010119-t1x9gknd 6927 14 testing testing NN cord-010119-t1x9gknd 6927 15 , , , cord-010119-t1x9gknd 6927 16 leading lead VBG cord-010119-t1x9gknd 6927 17 to to IN cord-010119-t1x9gknd 6927 18 long long JJ cord-010119-t1x9gknd 6927 19 work work NN cord-010119-t1x9gknd 6927 20 - - HYPH cord-010119-t1x9gknd 6927 21 ups up NNS cord-010119-t1x9gknd 6927 22 and and CC cord-010119-t1x9gknd 6927 23 potential potential JJ cord-010119-t1x9gknd 6927 24 transfusion transfusion NN cord-010119-t1x9gknd 6927 25 delays delay NNS cord-010119-t1x9gknd 6927 26 . . . cord-010119-t1x9gknd 6928 1 We -PRON- PRP cord-010119-t1x9gknd 6928 2 often often RB cord-010119-t1x9gknd 6928 3 use use VBP cord-010119-t1x9gknd 6928 4 automated automate VBN cord-010119-t1x9gknd 6928 5 solid solid JJ cord-010119-t1x9gknd 6928 6 phase phase NN cord-010119-t1x9gknd 6928 7 red red JJ cord-010119-t1x9gknd 6928 8 cell cell NN cord-010119-t1x9gknd 6928 9 adherence adherence NN cord-010119-t1x9gknd 6928 10 assay assay NN cord-010119-t1x9gknd 6928 11 antibody antibody NN cord-010119-t1x9gknd 6928 12 panels panel NNS cord-010119-t1x9gknd 6928 13 ( ( -LRB- cord-010119-t1x9gknd 6928 14 SP SP NNP cord-010119-t1x9gknd 6928 15 ) ) -RRB- cord-010119-t1x9gknd 6928 16 when when WRB cord-010119-t1x9gknd 6928 17 HTLA HTLA NNP cord-010119-t1x9gknd 6928 18 interference interference NN cord-010119-t1x9gknd 6928 19 is be VBZ cord-010119-t1x9gknd 6928 20 seen see VBN cord-010119-t1x9gknd 6928 21 by by IN cord-010119-t1x9gknd 6928 22 other other JJ cord-010119-t1x9gknd 6928 23 methods method NNS cord-010119-t1x9gknd 6928 24 , , , cord-010119-t1x9gknd 6928 25 and and CC cord-010119-t1x9gknd 6928 26 undertook undertake VBD cord-010119-t1x9gknd 6928 27 this this DT cord-010119-t1x9gknd 6928 28 study study NN cord-010119-t1x9gknd 6928 29 to to TO cord-010119-t1x9gknd 6928 30 determine determine VB cord-010119-t1x9gknd 6928 31 its -PRON- PRP$ cord-010119-t1x9gknd 6928 32 efficacy efficacy NN cord-010119-t1x9gknd 6928 33 . . . cord-010119-t1x9gknd 6929 1 Study Study NNP cord-010119-t1x9gknd 6929 2 Design Design NNP cord-010119-t1x9gknd 6929 3 / / SYM cord-010119-t1x9gknd 6929 4 Methods method NNS cord-010119-t1x9gknd 6929 5 : : : cord-010119-t1x9gknd 6930 1 A a DT cord-010119-t1x9gknd 6930 2 search search NN cord-010119-t1x9gknd 6930 3 of of IN cord-010119-t1x9gknd 6930 4 the the DT cord-010119-t1x9gknd 6930 5 laboratory laboratory NN cord-010119-t1x9gknd 6930 6 information information NN cord-010119-t1x9gknd 6930 7 system system NN cord-010119-t1x9gknd 6930 8 database database NN cord-010119-t1x9gknd 6930 9 was be VBD cord-010119-t1x9gknd 6930 10 conducted conduct VBN cord-010119-t1x9gknd 6930 11 for for IN cord-010119-t1x9gknd 6930 12 patients patient NNS cord-010119-t1x9gknd 6930 13 with with IN cord-010119-t1x9gknd 6930 14 HTLA HTLA NNP cord-010119-t1x9gknd 6930 15 between between IN cord-010119-t1x9gknd 6930 16 1/1/2006 1/1/2006 CD cord-010119-t1x9gknd 6930 17 and and CC cord-010119-t1x9gknd 6930 18 3/ 3/ CD cord-010119-t1x9gknd 6930 19 31/2017 31/2017 CD cord-010119-t1x9gknd 6930 20 . . . cord-010119-t1x9gknd 6931 1 All all DT cord-010119-t1x9gknd 6931 2 patient patient JJ cord-010119-t1x9gknd 6931 3 samples sample NNS cord-010119-t1x9gknd 6931 4 with with IN cord-010119-t1x9gknd 6931 5 available available JJ cord-010119-t1x9gknd 6931 6 records record NNS cord-010119-t1x9gknd 6931 7 of of IN cord-010119-t1x9gknd 6931 8 the the DT cord-010119-t1x9gknd 6931 9 full full JJ cord-010119-t1x9gknd 6931 10 serological serological JJ cord-010119-t1x9gknd 6931 11 investigation investigation NN cord-010119-t1x9gknd 6931 12 were be VBD cord-010119-t1x9gknd 6931 13 reviewed review VBN cord-010119-t1x9gknd 6931 14 for for IN cord-010119-t1x9gknd 6931 15 testing testing NN cord-010119-t1x9gknd 6931 16 method method NN cord-010119-t1x9gknd 6931 17 and and CC cord-010119-t1x9gknd 6931 18 results result NNS cord-010119-t1x9gknd 6931 19 , , , cord-010119-t1x9gknd 6931 20 with with IN cord-010119-t1x9gknd 6931 21 specific specific JJ cord-010119-t1x9gknd 6931 22 attention attention NN cord-010119-t1x9gknd 6931 23 to to IN cord-010119-t1x9gknd 6931 24 the the DT cord-010119-t1x9gknd 6931 25 value value NN cord-010119-t1x9gknd 6931 26 of of IN cord-010119-t1x9gknd 6931 27 a a DT cord-010119-t1x9gknd 6931 28 given give VBN cord-010119-t1x9gknd 6931 29 test test NN cord-010119-t1x9gknd 6931 30 method method NN cord-010119-t1x9gknd 6931 31 in in IN cord-010119-t1x9gknd 6931 32 permitting permit VBG cord-010119-t1x9gknd 6931 33 exclusion exclusion NN cord-010119-t1x9gknd 6931 34 of of IN cord-010119-t1x9gknd 6931 35 clinically clinically RB cord-010119-t1x9gknd 6931 36 significant significant JJ cord-010119-t1x9gknd 6931 37 AB ab NN cord-010119-t1x9gknd 6931 38 ( ( -LRB- cord-010119-t1x9gknd 6931 39 rule rule NN cord-010119-t1x9gknd 6931 40 out out RP cord-010119-t1x9gknd 6931 41 ) ) -RRB- cord-010119-t1x9gknd 6931 42 . . . cord-010119-t1x9gknd 6932 1 Results result NNS cord-010119-t1x9gknd 6932 2 / / SYM cord-010119-t1x9gknd 6932 3 Findings finding NNS cord-010119-t1x9gknd 6932 4 : : : cord-010119-t1x9gknd 6932 5 Over over IN cord-010119-t1x9gknd 6932 6 approximately approximately RB cord-010119-t1x9gknd 6932 7 11 11 CD cord-010119-t1x9gknd 6932 8 years year NNS cord-010119-t1x9gknd 6933 1 , , , cord-010119-t1x9gknd 6933 2 81 81 CD cord-010119-t1x9gknd 6933 3 patients patient NNS cord-010119-t1x9gknd 6933 4 had have VBD cord-010119-t1x9gknd 6933 5 HTLA HTLA NNP cord-010119-t1x9gknd 6933 6 established establish VBN cord-010119-t1x9gknd 6933 7 at at IN cord-010119-t1x9gknd 6933 8 least least JJS cord-010119-t1x9gknd 6933 9 once once RB cord-010119-t1x9gknd 6933 10 by by IN cord-010119-t1x9gknd 6933 11 titration titration NN cord-010119-t1x9gknd 6933 12 studies study NNS cord-010119-t1x9gknd 6933 13 . . . cord-010119-t1x9gknd 6934 1 Serological serological JJ cord-010119-t1x9gknd 6934 2 investigations investigation NNS cord-010119-t1x9gknd 6934 3 on on IN cord-010119-t1x9gknd 6934 4 a a DT cord-010119-t1x9gknd 6934 5 total total NN cord-010119-t1x9gknd 6934 6 of of IN cord-010119-t1x9gknd 6934 7 118 118 CD cord-010119-t1x9gknd 6934 8 samples sample NNS cord-010119-t1x9gknd 6934 9 using use VBG cord-010119-t1x9gknd 6934 10 a a DT cord-010119-t1x9gknd 6934 11 combination combination NN cord-010119-t1x9gknd 6934 12 of of IN cord-010119-t1x9gknd 6934 13 gel gel NN cord-010119-t1x9gknd 6934 14 , , , cord-010119-t1x9gknd 6934 15 SP SP NNP cord-010119-t1x9gknd 6934 16 , , , cord-010119-t1x9gknd 6934 17 and and CC cord-010119-t1x9gknd 6934 18 PEG PEG NNP cord-010119-t1x9gknd 6934 19 and and CC cord-010119-t1x9gknd 6934 20 LISS LISS NNP cord-010119-t1x9gknd 6934 21 tube tube NN cord-010119-t1x9gknd 6934 22 methods method NNS cord-010119-t1x9gknd 6934 23 , , , cord-010119-t1x9gknd 6934 24 and and CC cord-010119-t1x9gknd 6934 25 occasional occasional JJ cord-010119-t1x9gknd 6934 26 DTT dtt NN cord-010119-t1x9gknd 6934 27 and and CC cord-010119-t1x9gknd 6934 28 ficin ficin NNS cord-010119-t1x9gknd 6934 29 panels panel NNS cord-010119-t1x9gknd 6934 30 , , , cord-010119-t1x9gknd 6934 31 found find VBD cord-010119-t1x9gknd 6934 32 that that IN cord-010119-t1x9gknd 6934 33 HTLA HTLA NNP cord-010119-t1x9gknd 6934 34 interference interference NN cord-010119-t1x9gknd 6934 35 noted note VBD cord-010119-t1x9gknd 6934 36 most most RBS cord-010119-t1x9gknd 6934 37 frequently frequently RB cord-010119-t1x9gknd 6934 38 in in IN cord-010119-t1x9gknd 6934 39 gel gel NN cord-010119-t1x9gknd 6934 40 ( ( -LRB- cord-010119-t1x9gknd 6934 41 primary primary JJ cord-010119-t1x9gknd 6934 42 method method NN cord-010119-t1x9gknd 6934 43 ) ) -RRB- cord-010119-t1x9gknd 6934 44 was be VBD cord-010119-t1x9gknd 6934 45 , , , cord-010119-t1x9gknd 6934 46 indeed indeed RB cord-010119-t1x9gknd 6934 47 , , , cord-010119-t1x9gknd 6934 48 less less RBR cord-010119-t1x9gknd 6934 49 often often RB cord-010119-t1x9gknd 6934 50 seen see VBN cord-010119-t1x9gknd 6934 51 with with IN cord-010119-t1x9gknd 6934 52 SP SP NNP cord-010119-t1x9gknd 6934 53 . . . cord-010119-t1x9gknd 6935 1 However however RB cord-010119-t1x9gknd 6935 2 , , , cord-010119-t1x9gknd 6935 3 the the DT cord-010119-t1x9gknd 6935 4 proportion proportion NN cord-010119-t1x9gknd 6935 5 of of IN cord-010119-t1x9gknd 6935 6 cases case NNS cord-010119-t1x9gknd 6935 7 achieving achieve VBG cord-010119-t1x9gknd 6935 8 rule rule NN cord-010119-t1x9gknd 6935 9 out out RP cord-010119-t1x9gknd 6935 10 on on IN cord-010119-t1x9gknd 6935 11 SP SP NNP cord-010119-t1x9gknd 6935 12 was be VBD cord-010119-t1x9gknd 6935 13 no no RB cord-010119-t1x9gknd 6935 14 greater great JJR cord-010119-t1x9gknd 6935 15 than than IN cord-010119-t1x9gknd 6935 16 that that DT cord-010119-t1x9gknd 6935 17 with with IN cord-010119-t1x9gknd 6935 18 PEG peg NN cord-010119-t1x9gknd 6935 19 testing testing NN cord-010119-t1x9gknd 6935 20 ( ( -LRB- cord-010119-t1x9gknd 6935 21 Table table NN cord-010119-t1x9gknd 6935 22 ) ) -RRB- cord-010119-t1x9gknd 6935 23 . . . cord-010119-t1x9gknd 6936 1 For for IN cord-010119-t1x9gknd 6936 2 samples sample NNS cord-010119-t1x9gknd 6936 3 where where WRB cord-010119-t1x9gknd 6936 4 rule rule NN cord-010119-t1x9gknd 6936 5 out out RP cord-010119-t1x9gknd 6936 6 could could MD cord-010119-t1x9gknd 6936 7 not not RB cord-010119-t1x9gknd 6936 8 be be VB cord-010119-t1x9gknd 6936 9 performed perform VBN cord-010119-t1x9gknd 6936 10 with with IN cord-010119-t1x9gknd 6936 11 a a DT cord-010119-t1x9gknd 6936 12 combination combination NN cord-010119-t1x9gknd 6936 13 of of IN cord-010119-t1x9gknd 6936 14 methods method NNS cord-010119-t1x9gknd 6936 15 , , , cord-010119-t1x9gknd 6936 16 patients patient NNS cord-010119-t1x9gknd 6936 17 were be VBD cord-010119-t1x9gknd 6936 18 assigned assign VBN cord-010119-t1x9gknd 6936 19 to to IN cord-010119-t1x9gknd 6936 20 phenotype phenotype NN cord-010119-t1x9gknd 6936 21 - - HYPH cord-010119-t1x9gknd 6936 22 matched match VBN cord-010119-t1x9gknd 6936 23 transfusions transfusion NNS cord-010119-t1x9gknd 6936 24 , , , cord-010119-t1x9gknd 6936 25 or or CC cord-010119-t1x9gknd 6936 26 testing testing NN cord-010119-t1x9gknd 6936 27 was be VBD cord-010119-t1x9gknd 6936 28 referred refer VBN cord-010119-t1x9gknd 6936 29 to to IN cord-010119-t1x9gknd 6936 30 a a DT cord-010119-t1x9gknd 6936 31 reference reference NN cord-010119-t1x9gknd 6936 32 laboratory laboratory NN cord-010119-t1x9gknd 6936 33 . . . cord-010119-t1x9gknd 6937 1 Reference reference NN cord-010119-t1x9gknd 6937 2 testing testing NN cord-010119-t1x9gknd 6937 3 on on IN cord-010119-t1x9gknd 6937 4 20 20 CD cord-010119-t1x9gknd 6937 5 samples sample NNS cord-010119-t1x9gknd 6937 6 was be VBD cord-010119-t1x9gknd 6937 7 successful successful JJ cord-010119-t1x9gknd 6937 8 in in IN cord-010119-t1x9gknd 6937 9 rule rule NN cord-010119-t1x9gknd 6937 10 out out RP cord-010119-t1x9gknd 6937 11 in in IN cord-010119-t1x9gknd 6937 12 60 60 CD cord-010119-t1x9gknd 6937 13 % % NN cord-010119-t1x9gknd 6937 14 of of IN cord-010119-t1x9gknd 6937 15 cases case NNS cord-010119-t1x9gknd 6937 16 . . . cord-010119-t1x9gknd 6938 1 In in IN cord-010119-t1x9gknd 6938 2 an an DT cord-010119-t1x9gknd 6938 3 additional additional JJ cord-010119-t1x9gknd 6938 4 12 12 CD cord-010119-t1x9gknd 6938 5 patient patient NN cord-010119-t1x9gknd 6938 6 samples sample NNS cord-010119-t1x9gknd 6938 7 , , , cord-010119-t1x9gknd 6938 8 with with IN cord-010119-t1x9gknd 6938 9 negative negative JJ cord-010119-t1x9gknd 6938 10 antibody antibody NN cord-010119-t1x9gknd 6938 11 screens screen NNS cord-010119-t1x9gknd 6938 12 , , , cord-010119-t1x9gknd 6938 13 HTLA HTLA NNP cord-010119-t1x9gknd 6938 14 were be VBD cord-010119-t1x9gknd 6938 15 identified identify VBN cord-010119-t1x9gknd 6938 16 upon upon IN cord-010119-t1x9gknd 6938 17 work work NN cord-010119-t1x9gknd 6938 18 - - HYPH cord-010119-t1x9gknd 6938 19 up up NN cord-010119-t1x9gknd 6938 20 for for IN cord-010119-t1x9gknd 6938 21 incompatible incompatible JJ cord-010119-t1x9gknd 6938 22 crossmatches crossmatche NNS cord-010119-t1x9gknd 6938 23 . . . cord-010119-t1x9gknd 6939 1 Conclusion conclusion NN cord-010119-t1x9gknd 6939 2 : : : cord-010119-t1x9gknd 6939 3 SP SP NNP cord-010119-t1x9gknd 6939 4 is be VBZ cord-010119-t1x9gknd 6939 5 useful useful JJ cord-010119-t1x9gknd 6939 6 in in IN cord-010119-t1x9gknd 6939 7 avoiding avoid VBG cord-010119-t1x9gknd 6939 8 interference interference NN cord-010119-t1x9gknd 6939 9 from from IN cord-010119-t1x9gknd 6939 10 HTLA HTLA NNP cord-010119-t1x9gknd 6939 11 , , , cord-010119-t1x9gknd 6939 12 but but CC cord-010119-t1x9gknd 6939 13 this this DT cord-010119-t1x9gknd 6939 14 conclusion conclusion NN cord-010119-t1x9gknd 6939 15 is be VBZ cord-010119-t1x9gknd 6939 16 limited limit VBN cord-010119-t1x9gknd 6939 17 because because IN cord-010119-t1x9gknd 6939 18 SP SP NNP cord-010119-t1x9gknd 6939 19 was be VBD cord-010119-t1x9gknd 6939 20 performed perform VBN cord-010119-t1x9gknd 6939 21 in in IN cord-010119-t1x9gknd 6939 22 only only RB cord-010119-t1x9gknd 6939 23 40 40 CD cord-010119-t1x9gknd 6939 24 % % NN cord-010119-t1x9gknd 6939 25 of of IN cord-010119-t1x9gknd 6939 26 samples sample NNS cord-010119-t1x9gknd 6939 27 , , , cord-010119-t1x9gknd 6939 28 and and CC cord-010119-t1x9gknd 6939 29 the the DT cord-010119-t1x9gknd 6939 30 inability inability NN cord-010119-t1x9gknd 6939 31 to to TO cord-010119-t1x9gknd 6939 32 use use VB cord-010119-t1x9gknd 6939 33 select select JJ cord-010119-t1x9gknd 6939 34 cell cell NN cord-010119-t1x9gknd 6939 35 panels panel NNS cord-010119-t1x9gknd 6939 36 with with IN cord-010119-t1x9gknd 6939 37 SP SP NNP cord-010119-t1x9gknd 6939 38 made make VBD cord-010119-t1x9gknd 6939 39 it -PRON- PRP cord-010119-t1x9gknd 6939 40 difficult difficult JJ cord-010119-t1x9gknd 6939 41 to to TO cord-010119-t1x9gknd 6939 42 complete complete VB cord-010119-t1x9gknd 6939 43 rule rule NN cord-010119-t1x9gknd 6939 44 out out RP cord-010119-t1x9gknd 6939 45 on on IN cord-010119-t1x9gknd 6939 46 samples sample NNS cord-010119-t1x9gknd 6939 47 containing contain VBG cord-010119-t1x9gknd 6939 48 multiple multiple JJ cord-010119-t1x9gknd 6939 49 AB ab NN cord-010119-t1x9gknd 6939 50 . . . cord-010119-t1x9gknd 6940 1 PEG peg NN cord-010119-t1x9gknd 6940 2 testing testing NN cord-010119-t1x9gknd 6940 3 was be VBD cord-010119-t1x9gknd 6940 4 available available JJ cord-010119-t1x9gknd 6940 5 for for IN cord-010119-t1x9gknd 6940 6 71 71 CD cord-010119-t1x9gknd 6940 7 % % NN cord-010119-t1x9gknd 6940 8 of of IN cord-010119-t1x9gknd 6940 9 samples sample NNS cord-010119-t1x9gknd 6940 10 , , , cord-010119-t1x9gknd 6940 11 and and CC cord-010119-t1x9gknd 6940 12 was be VBD cord-010119-t1x9gknd 6940 13 at at IN cord-010119-t1x9gknd 6940 14 least least JJS cord-010119-t1x9gknd 6940 15 as as IN cord-010119-t1x9gknd 6940 16 effective effective JJ cord-010119-t1x9gknd 6940 17 . . . cord-010119-t1x9gknd 6941 1 Further further RB cord-010119-t1x9gknd 6941 2 , , , cord-010119-t1x9gknd 6941 3 manual manual JJ cord-010119-t1x9gknd 6941 4 testing testing NN cord-010119-t1x9gknd 6941 5 allowed allow VBD cord-010119-t1x9gknd 6941 6 flexibility flexibility NN cord-010119-t1x9gknd 6941 7 in in IN cord-010119-t1x9gknd 6941 8 selecting select VBG cord-010119-t1x9gknd 6941 9 test test NN cord-010119-t1x9gknd 6941 10 cells cell NNS cord-010119-t1x9gknd 6941 11 when when WRB cord-010119-t1x9gknd 6941 12 other other JJ cord-010119-t1x9gknd 6941 13 AB AB NNP cord-010119-t1x9gknd 6941 14 were be VBD cord-010119-t1x9gknd 6941 15 present present JJ cord-010119-t1x9gknd 6941 16 . . . cord-010119-t1x9gknd 6942 1 Both both DT cord-010119-t1x9gknd 6942 2 SP SP NNP cord-010119-t1x9gknd 6942 3 and and CC cord-010119-t1x9gknd 6942 4 PEG PEG NNP cord-010119-t1x9gknd 6942 5 testing testing NN cord-010119-t1x9gknd 6942 6 may may MD cord-010119-t1x9gknd 6942 7 be be VB cord-010119-t1x9gknd 6942 8 used use VBN cord-010119-t1x9gknd 6942 9 alone alone RB cord-010119-t1x9gknd 6942 10 or or CC cord-010119-t1x9gknd 6942 11 in in IN cord-010119-t1x9gknd 6942 12 combination combination NN cord-010119-t1x9gknd 6942 13 to to TO cord-010119-t1x9gknd 6942 14 avoid avoid VB cord-010119-t1x9gknd 6942 15 interference interference NN cord-010119-t1x9gknd 6942 16 due due IN cord-010119-t1x9gknd 6942 17 to to IN cord-010119-t1x9gknd 6942 18 HTLA HTLA NNP cord-010119-t1x9gknd 6942 19 , , , cord-010119-t1x9gknd 6942 20 and and CC cord-010119-t1x9gknd 6942 21 can can MD cord-010119-t1x9gknd 6942 22 potentially potentially RB cord-010119-t1x9gknd 6942 23 decrease decrease VB cord-010119-t1x9gknd 6942 24 the the DT cord-010119-t1x9gknd 6942 25 number number NN cord-010119-t1x9gknd 6942 26 of of IN cord-010119-t1x9gknd 6942 27 patients patient NNS cord-010119-t1x9gknd 6942 28 requiring require VBG cord-010119-t1x9gknd 6942 29 phenotype phenotype NN cord-010119-t1x9gknd 6942 30 - - HYPH cord-010119-t1x9gknd 6942 31 matched match VBN cord-010119-t1x9gknd 6942 32 units unit NNS cord-010119-t1x9gknd 6942 33 due due JJ cord-010119-t1x9gknd 6942 34 to to IN cord-010119-t1x9gknd 6942 35 incomplete incomplete JJ cord-010119-t1x9gknd 6942 36 serological serological JJ cord-010119-t1x9gknd 6942 37 evaluations evaluation NNS cord-010119-t1x9gknd 6942 38 . . . cord-010119-t1x9gknd 6943 1 Background Background NNP cord-010119-t1x9gknd 6943 2 / / SYM cord-010119-t1x9gknd 6943 3 Case Case NNP cord-010119-t1x9gknd 6943 4 Studies Studies NNPS cord-010119-t1x9gknd 6943 5 : : : cord-010119-t1x9gknd 6944 1 The the DT cord-010119-t1x9gknd 6944 2 DAU dau NN cord-010119-t1x9gknd 6944 3 family family NN cord-010119-t1x9gknd 6944 4 of of IN cord-010119-t1x9gknd 6944 5 RHD RHD NNP cord-010119-t1x9gknd 6944 6 alleles allele NNS cord-010119-t1x9gknd 6944 7 is be VBZ cord-010119-t1x9gknd 6944 8 characterized characterize VBN cord-010119-t1x9gknd 6944 9 by by IN cord-010119-t1x9gknd 6944 10 c.1136C c.1136c PRP cord-010119-t1x9gknd 6944 11 > > XX cord-010119-t1x9gknd 6945 1 T T NNP cord-010119-t1x9gknd 6945 2 ( ( -LRB- cord-010119-t1x9gknd 6945 3 p p NN cord-010119-t1x9gknd 6945 4 . . . cord-010119-t1x9gknd 6945 5 Thr379Met thr379met CD cord-010119-t1x9gknd 6945 6 ) ) -RRB- cord-010119-t1x9gknd 6945 7 . . . cord-010119-t1x9gknd 6946 1 The the DT cord-010119-t1x9gknd 6946 2 DAU0 DAU0 NNP cord-010119-t1x9gknd 6946 3 allele allele NN cord-010119-t1x9gknd 6946 4 harbors harbor VBZ cord-010119-t1x9gknd 6946 5 only only RB cord-010119-t1x9gknd 6946 6 this this DT cord-010119-t1x9gknd 6946 7 change change NN cord-010119-t1x9gknd 6946 8 , , , cord-010119-t1x9gknd 6946 9 is be VBZ cord-010119-t1x9gknd 6946 10 not not RB cord-010119-t1x9gknd 6946 11 associated associate VBN cord-010119-t1x9gknd 6946 12 with with IN cord-010119-t1x9gknd 6946 13 depressed depressed JJ cord-010119-t1x9gknd 6946 14 or or CC cord-010119-t1x9gknd 6946 15 altered alter VBN cord-010119-t1x9gknd 6946 16 D d NN cord-010119-t1x9gknd 6946 17 antigen antigen NN cord-010119-t1x9gknd 6946 18 expression expression NN cord-010119-t1x9gknd 6946 19 , , , cord-010119-t1x9gknd 6946 20 and and CC cord-010119-t1x9gknd 6946 21 is be VBZ cord-010119-t1x9gknd 6946 22 the the DT cord-010119-t1x9gknd 6946 23 ancestral ancestral JJ cord-010119-t1x9gknd 6946 24 allele allele NN cord-010119-t1x9gknd 6946 25 from from IN cord-010119-t1x9gknd 6946 26 which which WDT cord-010119-t1x9gknd 6946 27 other other JJ cord-010119-t1x9gknd 6946 28 DAU dau NN cord-010119-t1x9gknd 6946 29 alleles allele NNS cord-010119-t1x9gknd 6946 30 are be VBP cord-010119-t1x9gknd 6946 31 purported purport VBN cord-010119-t1x9gknd 6946 32 to to TO cord-010119-t1x9gknd 6946 33 have have VB cord-010119-t1x9gknd 6946 34 evolved evolve VBN cord-010119-t1x9gknd 6946 35 . . . cord-010119-t1x9gknd 6947 1 Srivastava Srivastava NNP cord-010119-t1x9gknd 6947 2 et et NNP cord-010119-t1x9gknd 6947 3 al al NNP cord-010119-t1x9gknd 6947 4 ( ( -LRB- cord-010119-t1x9gknd 6947 5 Transfusion transfusion NN cord-010119-t1x9gknd 6947 6 2016 2016 CD cord-010119-t1x9gknd 6947 7 , , , cord-010119-t1x9gknd 6947 8 56:2520 56:2520 CD cord-010119-t1x9gknd 6947 9 ) ) -RRB- cord-010119-t1x9gknd 6947 10 recently recently RB cord-010119-t1x9gknd 6947 11 summarized summarize VBN cord-010119-t1x9gknd 6947 12 serologic serologic JJ cord-010119-t1x9gknd 6947 13 characteristics characteristic NNS cord-010119-t1x9gknd 6947 14 and and CC cord-010119-t1x9gknd 6947 15 associated associated JJ cord-010119-t1x9gknd 6947 16 anti anti JJ cord-010119-t1x9gknd 6947 17 - - JJ cord-010119-t1x9gknd 6947 18 D d JJ cord-010119-t1x9gknd 6947 19 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6947 20 for for IN cord-010119-t1x9gknd 6947 21 18 18 CD cord-010119-t1x9gknd 6947 22 DAU dau NN cord-010119-t1x9gknd 6947 23 family family NN cord-010119-t1x9gknd 6947 24 alleles allele NNS cord-010119-t1x9gknd 6947 25 . . . cord-010119-t1x9gknd 6948 1 We -PRON- PRP cord-010119-t1x9gknd 6948 2 investigated investigate VBD cord-010119-t1x9gknd 6948 3 two two CD cord-010119-t1x9gknd 6948 4 samples sample NNS cord-010119-t1x9gknd 6948 5 with with IN cord-010119-t1x9gknd 6948 6 the the DT cord-010119-t1x9gknd 6948 7 c.1136C c.1136c NN cord-010119-t1x9gknd 6949 1 > > XX cord-010119-t1x9gknd 6950 1 T T NNP cord-010119-t1x9gknd 6950 2 change change NN cord-010119-t1x9gknd 6950 3 referred refer VBN cord-010119-t1x9gknd 6950 4 with with IN cord-010119-t1x9gknd 6950 5 weak weak JJ cord-010119-t1x9gknd 6950 6 D D NNP cord-010119-t1x9gknd 6950 7 antigen antigen NN cord-010119-t1x9gknd 6950 8 expression expression NN cord-010119-t1x9gknd 6950 9 . . . cord-010119-t1x9gknd 6951 1 Study Study NNP cord-010119-t1x9gknd 6951 2 Design Design NNP cord-010119-t1x9gknd 6951 3 / / SYM cord-010119-t1x9gknd 6951 4 Method method NN cord-010119-t1x9gknd 6951 5 : : : cord-010119-t1x9gknd 6951 6 Serologic Serologic NNP cord-010119-t1x9gknd 6951 7 testing testing NN cord-010119-t1x9gknd 6951 8 was be VBD cord-010119-t1x9gknd 6951 9 performed perform VBN cord-010119-t1x9gknd 6951 10 by by IN cord-010119-t1x9gknd 6951 11 standard standard JJ cord-010119-t1x9gknd 6951 12 tube tube NN cord-010119-t1x9gknd 6951 13 methods method NNS cord-010119-t1x9gknd 6951 14 using use VBG cord-010119-t1x9gknd 6951 15 licensed license VBN cord-010119-t1x9gknd 6951 16 anti anti JJ cord-010119-t1x9gknd 6951 17 - - JJ cord-010119-t1x9gknd 6951 18 D d JJ cord-010119-t1x9gknd 6951 19 reagents reagent NNS cord-010119-t1x9gknd 6951 20 and and CC cord-010119-t1x9gknd 6951 21 the the DT cord-010119-t1x9gknd 6951 22 ALBAclone ALBAclone NNP cord-010119-t1x9gknd 6951 23 partial partial JJ cord-010119-t1x9gknd 6951 24 RhD RhD NNP cord-010119-t1x9gknd 6951 25 typing typing NN cord-010119-t1x9gknd 6951 26 kit kit NN cord-010119-t1x9gknd 6951 27 . . . cord-010119-t1x9gknd 6952 1 Genomic genomic JJ cord-010119-t1x9gknd 6952 2 DNA dna NN cord-010119-t1x9gknd 6952 3 was be VBD cord-010119-t1x9gknd 6952 4 isolated isolate VBN cord-010119-t1x9gknd 6952 5 from from IN cord-010119-t1x9gknd 6952 6 WBCs wbc NNS cord-010119-t1x9gknd 6952 7 and and CC cord-010119-t1x9gknd 6952 8 used use VBN cord-010119-t1x9gknd 6952 9 in in IN cord-010119-t1x9gknd 6952 10 manual manual JJ cord-010119-t1x9gknd 6952 11 and and CC cord-010119-t1x9gknd 6952 12 array array NN cord-010119-t1x9gknd 6952 13 assays assay NNS cord-010119-t1x9gknd 6952 14 and and CC cord-010119-t1x9gknd 6952 15 for for IN cord-010119-t1x9gknd 6952 16 amplification amplification NN cord-010119-t1x9gknd 6952 17 and and CC cord-010119-t1x9gknd 6952 18 sequencing sequencing NN cord-010119-t1x9gknd 6952 19 RHD RHD NNP cord-010119-t1x9gknd 6952 20 . . . cord-010119-t1x9gknd 6953 1 Results/ Results/ . cord-010119-t1x9gknd 6954 1 Finding finding NN cord-010119-t1x9gknd 6954 2 : : : cord-010119-t1x9gknd 6955 1 Sample sample NN cord-010119-t1x9gknd 6955 2 1 1 CD cord-010119-t1x9gknd 6955 3 was be VBD cord-010119-t1x9gknd 6955 4 from from IN cord-010119-t1x9gknd 6955 5 a a DT cord-010119-t1x9gknd 6955 6 17 17 CD cord-010119-t1x9gknd 6955 7 yo yo NNP cord-010119-t1x9gknd 6955 8 multiracial multiracial JJ cord-010119-t1x9gknd 6955 9 female female NN cord-010119-t1x9gknd 6955 10 . . . cord-010119-t1x9gknd 6956 1 Her -PRON- PRP$ cord-010119-t1x9gknd 6956 2 RBCs rbc NNS cord-010119-t1x9gknd 6956 3 reacted react VBD cord-010119-t1x9gknd 6956 4 11 11 CD cord-010119-t1x9gknd 6956 5 S S NNS cord-010119-t1x9gknd 6956 6 at at IN cord-010119-t1x9gknd 6956 7 immediate immediate JJ cord-010119-t1x9gknd 6956 8 spin spin NN cord-010119-t1x9gknd 6956 9 ( ( -LRB- cord-010119-t1x9gknd 6956 10 IS be VBZ cord-010119-t1x9gknd 6956 11 ) ) -RRB- cord-010119-t1x9gknd 6956 12 and and CC cord-010119-t1x9gknd 6956 13 31 31 CD cord-010119-t1x9gknd 6956 14 in in IN cord-010119-t1x9gknd 6956 15 IAT IAT NNP cord-010119-t1x9gknd 6956 16 with with IN cord-010119-t1x9gknd 6956 17 Immucor Immucor NNP cord-010119-t1x9gknd 6956 18 Gammaclone Gammaclone NNP cord-010119-t1x9gknd 6956 19 and and CC cord-010119-t1x9gknd 6956 20 Series Series NNP cord-010119-t1x9gknd 6956 21 4 4 CD cord-010119-t1x9gknd 6956 22 and and CC cord-010119-t1x9gknd 6956 23 5 5 CD cord-010119-t1x9gknd 6956 24 , , , cord-010119-t1x9gknd 6956 25 and and CC cord-010119-t1x9gknd 6956 26 mi1 mi1 NNS cord-010119-t1x9gknd 6956 27 at at IN cord-010119-t1x9gknd 6956 28 IS is NN cord-010119-t1x9gknd 6956 29 and and CC cord-010119-t1x9gknd 6956 30 41 41 CD cord-010119-t1x9gknd 6956 31 in in IN cord-010119-t1x9gknd 6956 32 IAT IAT NNP cord-010119-t1x9gknd 6956 33 with with IN cord-010119-t1x9gknd 6956 34 Ortho Ortho NNP cord-010119-t1x9gknd 6956 35 BioClone BioClone NNP cord-010119-t1x9gknd 6956 36 anti anti JJ cord-010119-t1x9gknd 6956 37 - - NNP cord-010119-t1x9gknd 6956 38 D. D. NNP cord-010119-t1x9gknd 6956 39 RBCs rbc NNS cord-010119-t1x9gknd 6956 40 did do VBD cord-010119-t1x9gknd 6956 41 not not RB cord-010119-t1x9gknd 6956 42 react react VB cord-010119-t1x9gknd 6956 43 with with IN cord-010119-t1x9gknd 6956 44 2 2 CD cord-010119-t1x9gknd 6956 45 of of IN cord-010119-t1x9gknd 6956 46 12 12 CD cord-010119-t1x9gknd 6956 47 ( ( -LRB- cord-010119-t1x9gknd 6956 48 LHM LHM NNP cord-010119-t1x9gknd 6956 49 174/102 174/102 NNP cord-010119-t1x9gknd 6956 50 & & CC cord-010119-t1x9gknd 6956 51 57/17 57/17 CD cord-010119-t1x9gknd 6956 52 ) ) -RRB- cord-010119-t1x9gknd 6957 1 anti anti JJ cord-010119-t1x9gknd 6957 2 - - JJ cord-010119-t1x9gknd 6957 3 D d JJ cord-010119-t1x9gknd 6957 4 in in IN cord-010119-t1x9gknd 6957 5 the the DT cord-010119-t1x9gknd 6957 6 partial partial JJ cord-010119-t1x9gknd 6957 7 D d NN cord-010119-t1x9gknd 6957 8 typing typing NN cord-010119-t1x9gknd 6957 9 kit kit NN cord-010119-t1x9gknd 6957 10 . . . cord-010119-t1x9gknd 6958 1 This this DT cord-010119-t1x9gknd 6958 2 pattern pattern NN cord-010119-t1x9gknd 6958 3 did do VBD cord-010119-t1x9gknd 6958 4 not not RB cord-010119-t1x9gknd 6958 5 match match VB cord-010119-t1x9gknd 6958 6 any any DT cord-010119-t1x9gknd 6958 7 of of IN cord-010119-t1x9gknd 6958 8 the the DT cord-010119-t1x9gknd 6958 9 defined define VBN cord-010119-t1x9gknd 6958 10 partial partial JJ cord-010119-t1x9gknd 6958 11 D d NN cord-010119-t1x9gknd 6958 12 epitope epitope NN cord-010119-t1x9gknd 6958 13 patterns pattern NNS cord-010119-t1x9gknd 6958 14 . . . cord-010119-t1x9gknd 6959 1 RHD RHD NNP cord-010119-t1x9gknd 6959 2 BeadChip BeadChip NNP cord-010119-t1x9gknd 6959 3 found find VBD cord-010119-t1x9gknd 6959 4 no no DT cord-010119-t1x9gknd 6959 5 changes change NNS cord-010119-t1x9gknd 6959 6 but but CC cord-010119-t1x9gknd 6959 7 RFLP RFLP NNP cord-010119-t1x9gknd 6959 8 detected detect VBD cord-010119-t1x9gknd 6960 1 c.1136C c.1136C NNP cord-010119-t1x9gknd 6961 1 > > XX cord-010119-t1x9gknd 6962 1 T T NNP cord-010119-t1x9gknd 6962 2 characteristic characteristic NN cord-010119-t1x9gknd 6962 3 of of IN cord-010119-t1x9gknd 6962 4 DAU DAU NNP cord-010119-t1x9gknd 6962 5 . . . cord-010119-t1x9gknd 6963 1 RHD RHD NNP cord-010119-t1x9gknd 6963 2 sequencing sequencing NN cord-010119-t1x9gknd 6963 3 confirmed confirm VBD cord-010119-t1x9gknd 6963 4 c.1136C c.1136c CD cord-010119-t1x9gknd 6964 1 > > XX cord-010119-t1x9gknd 6965 1 T T NNP cord-010119-t1x9gknd 6965 2 and and CC cord-010119-t1x9gknd 6965 3 identified identify VBD cord-010119-t1x9gknd 6965 4 two two CD cord-010119-t1x9gknd 6965 5 adjacent adjacent JJ cord-010119-t1x9gknd 6965 6 changes change NNS cord-010119-t1x9gknd 6965 7 , , , cord-010119-t1x9gknd 6965 8 c.787 c.787 NNP cord-010119-t1x9gknd 6965 9 G g NN cord-010119-t1x9gknd 6966 1 > > XX cord-010119-t1x9gknd 6967 1 T T NNP cord-010119-t1x9gknd 6967 2 and and CC cord-010119-t1x9gknd 6967 3 c.788G c.788G NNP cord-010119-t1x9gknd 6967 4 > > XX cord-010119-t1x9gknd 6967 5 T T NNP cord-010119-t1x9gknd 6967 6 ( ( -LRB- cord-010119-t1x9gknd 6967 7 c.787_788delinsTT c.787_788delinsTT NNP cord-010119-t1x9gknd 6967 8 ) ) -RRB- cord-010119-t1x9gknd 6967 9 , , , cord-010119-t1x9gknd 6967 10 in in IN cord-010119-t1x9gknd 6967 11 exon exon NN cord-010119-t1x9gknd 6967 12 5 5 CD cord-010119-t1x9gknd 6967 13 encoding encoding NN cord-010119-t1x9gknd 6967 14 p. p. NN cord-010119-t1x9gknd 6968 1 Gly263Leu Gly263Leu NNP cord-010119-t1x9gknd 6968 2 . . . cord-010119-t1x9gknd 6969 1 Sample sample NN cord-010119-t1x9gknd 6969 2 2 2 CD cord-010119-t1x9gknd 6969 3 RBCs rbc NNS cord-010119-t1x9gknd 6969 4 reacted react VBD cord-010119-t1x9gknd 6969 5 1w 1w CD cord-010119-t1x9gknd 6969 6 at at IN cord-010119-t1x9gknd 6969 7 IAT IAT NNP cord-010119-t1x9gknd 6969 8 with with IN cord-010119-t1x9gknd 6969 9 both both CC cord-010119-t1x9gknd 6969 10 Ortho Ortho NNP cord-010119-t1x9gknd 6969 11 BioClone BioClone NNP cord-010119-t1x9gknd 6969 12 and and CC cord-010119-t1x9gknd 6969 13 Quotient Quotient NNP cord-010119-t1x9gknd 6969 14 ALBAclone ALBAclone NNP cord-010119-t1x9gknd 6969 15 Delta Delta NNP cord-010119-t1x9gknd 6969 16 , , , cord-010119-t1x9gknd 6969 17 but but CC cord-010119-t1x9gknd 6969 18 were be VBD cord-010119-t1x9gknd 6969 19 non non JJ cord-010119-t1x9gknd 6969 20 - - JJ cord-010119-t1x9gknd 6969 21 reactive reactive JJ cord-010119-t1x9gknd 6969 22 with with IN cord-010119-t1x9gknd 6969 23 Immucor Immucor NNP cord-010119-t1x9gknd 6969 24 Gamma Gamma NNP cord-010119-t1x9gknd 6969 25 - - HYPH cord-010119-t1x9gknd 6969 26 clone clone NN cord-010119-t1x9gknd 6969 27 , , , cord-010119-t1x9gknd 6969 28 Series Series NNP cord-010119-t1x9gknd 6969 29 4 4 CD cord-010119-t1x9gknd 6969 30 and and CC cord-010119-t1x9gknd 6969 31 5 5 CD cord-010119-t1x9gknd 6969 32 , , , cord-010119-t1x9gknd 6969 33 and and CC cord-010119-t1x9gknd 6969 34 Quotient Quotient NNP cord-010119-t1x9gknd 6969 35 ALBAclone ALBAclone NNP cord-010119-t1x9gknd 6969 36 blend blend NN cord-010119-t1x9gknd 6969 37 and and CC cord-010119-t1x9gknd 6969 38 alpha alpha NNP cord-010119-t1x9gknd 6969 39 anti anti NNP cord-010119-t1x9gknd 6969 40 - - NNP cord-010119-t1x9gknd 6969 41 D. D. NNP cord-010119-t1x9gknd 6969 42 Papain Papain NNP cord-010119-t1x9gknd 6969 43 treated treat VBD cord-010119-t1x9gknd 6969 44 RBCs rbc NNS cord-010119-t1x9gknd 6969 45 were be VBD cord-010119-t1x9gknd 6969 46 11s 11 NNS cord-010119-t1x9gknd 6969 47 in in IN cord-010119-t1x9gknd 6969 48 IAT IAT NNP cord-010119-t1x9gknd 6969 49 with with IN cord-010119-t1x9gknd 6969 50 Ortho Ortho NNP cord-010119-t1x9gknd 6969 51 BioClone BioClone NNP cord-010119-t1x9gknd 6969 52 . . . cord-010119-t1x9gknd 6970 1 These these DT cord-010119-t1x9gknd 6970 2 results result NNS cord-010119-t1x9gknd 6970 3 suggested suggest VBD cord-010119-t1x9gknd 6970 4 a a DT cord-010119-t1x9gknd 6970 5 D d NN cord-010119-t1x9gknd 6970 6 el el NNP cord-010119-t1x9gknd 6970 7 like like IN cord-010119-t1x9gknd 6970 8 phenotype phenotype NN cord-010119-t1x9gknd 6970 9 . . . cord-010119-t1x9gknd 6971 1 RHD RHD NNP cord-010119-t1x9gknd 6971 2 BeadChip BeadChip NNP cord-010119-t1x9gknd 6971 3 found find VBD cord-010119-t1x9gknd 6971 4 no no DT cord-010119-t1x9gknd 6971 5 changes change NNS cord-010119-t1x9gknd 6971 6 but but CC cord-010119-t1x9gknd 6971 7 RFLP RFLP NNP cord-010119-t1x9gknd 6971 8 detected detect VBD cord-010119-t1x9gknd 6971 9 c.1136C c.1136c CD cord-010119-t1x9gknd 6972 1 > > XX cord-010119-t1x9gknd 6973 1 T. T. NNP cord-010119-t1x9gknd 6973 2 Sequencing Sequencing NNP cord-010119-t1x9gknd 6973 3 confirmed confirm VBD cord-010119-t1x9gknd 6973 4 c.1136C c.1136c CD cord-010119-t1x9gknd 6974 1 > > XX cord-010119-t1x9gknd 6975 1 T T NNP cord-010119-t1x9gknd 6975 2 and and CC cord-010119-t1x9gknd 6975 3 found find VBD cord-010119-t1x9gknd 6975 4 a a DT cord-010119-t1x9gknd 6975 5 new new JJ cord-010119-t1x9gknd 6975 6 c.761C c.761C NNP cord-010119-t1x9gknd 6976 1 > > XX cord-010119-t1x9gknd 6977 1 T T NNP cord-010119-t1x9gknd 6977 2 change change NN cord-010119-t1x9gknd 6977 3 ( ( -LRB- cord-010119-t1x9gknd 6977 4 p p NN cord-010119-t1x9gknd 6977 5 . . . cord-010119-t1x9gknd 6977 6 Ser254-Leu Ser254-Leu NNP cord-010119-t1x9gknd 6977 7 ) ) -RRB- cord-010119-t1x9gknd 6977 8 in in IN cord-010119-t1x9gknd 6977 9 exon exon NN cord-010119-t1x9gknd 6977 10 5 5 CD cord-010119-t1x9gknd 6977 11 . . . cord-010119-t1x9gknd 6978 1 The the DT cord-010119-t1x9gknd 6978 2 c.761 c.761 NN cord-010119-t1x9gknd 6978 3 T t NN cord-010119-t1x9gknd 6978 4 has have VBZ cord-010119-t1x9gknd 6978 5 not not RB cord-010119-t1x9gknd 6978 6 been be VBN cord-010119-t1x9gknd 6978 7 reported report VBN cord-010119-t1x9gknd 6978 8 , , , cord-010119-t1x9gknd 6978 9 but but CC cord-010119-t1x9gknd 6978 10 c.761 c.761 NN cord-010119-t1x9gknd 6978 11 G g NN cord-010119-t1x9gknd 6978 12 encodes encode VBZ cord-010119-t1x9gknd 6978 13 a a DT cord-010119-t1x9gknd 6978 14 stop stop NN cord-010119-t1x9gknd 6978 15 codon codon NN cord-010119-t1x9gknd 6978 16 ( ( -LRB- cord-010119-t1x9gknd 6978 17 p p NN cord-010119-t1x9gknd 6978 18 . . . cord-010119-t1x9gknd 6978 19 Ser254Stop Ser254Stop NNP cord-010119-t1x9gknd 6978 20 ) ) -RRB- cord-010119-t1x9gknd 6978 21 in in IN cord-010119-t1x9gknd 6978 22 Japanese japanese JJ cord-010119-t1x9gknd 6978 23 ( ( -LRB- cord-010119-t1x9gknd 6978 24 Vox Vox NNP cord-010119-t1x9gknd 6978 25 Sang Sang NNP cord-010119-t1x9gknd 6978 26 2015 2015 CD cord-010119-t1x9gknd 6978 27 , , , cord-010119-t1x9gknd 6978 28 109:359 109:359 CD cord-010119-t1x9gknd 6978 29 ) ) -RRB- cord-010119-t1x9gknd 6978 30 . . . cord-010119-t1x9gknd 6979 1 Conclusion conclusion NN cord-010119-t1x9gknd 6979 2 : : : cord-010119-t1x9gknd 6980 1 We -PRON- PRP cord-010119-t1x9gknd 6980 2 report report VBP cord-010119-t1x9gknd 6980 3 two two CD cord-010119-t1x9gknd 6980 4 new new JJ cord-010119-t1x9gknd 6980 5 alleles allele NNS cord-010119-t1x9gknd 6980 6 : : : cord-010119-t1x9gknd 6980 7 RHD RHD NNP cord-010119-t1x9gknd 6980 8 with with IN cord-010119-t1x9gknd 6980 9 c.787_788delinsTT c.787_788delinstt NN cord-010119-t1x9gknd 6981 1 ( ( -LRB- cord-010119-t1x9gknd 6981 2 p p NN cord-010119-t1x9gknd 6981 3 . . . cord-010119-t1x9gknd 6981 4 Gly263Leu Gly263Leu NNP cord-010119-t1x9gknd 6981 5 ) ) -RRB- cord-010119-t1x9gknd 6981 6 and and CC cord-010119-t1x9gknd 6981 7 RHD RHD NNP cord-010119-t1x9gknd 6981 8 with with IN cord-010119-t1x9gknd 6981 9 c.761C c.761C NNP cord-010119-t1x9gknd 6982 1 > > XX cord-010119-t1x9gknd 6983 1 T T NNP cord-010119-t1x9gknd 6983 2 ( ( -LRB- cord-010119-t1x9gknd 6983 3 p. p. NN cord-010119-t1x9gknd 6984 1 Ser254Leu Ser254Leu NNP cord-010119-t1x9gknd 6984 2 ) ) -RRB- cord-010119-t1x9gknd 6984 3 , , , cord-010119-t1x9gknd 6984 4 both both DT cord-010119-t1x9gknd 6984 5 also also RB cord-010119-t1x9gknd 6984 6 carrying carry VBG cord-010119-t1x9gknd 6984 7 the the DT cord-010119-t1x9gknd 6984 8 c.1136C c.1136c NN cord-010119-t1x9gknd 6985 1 > > XX cord-010119-t1x9gknd 6986 1 T T NNP cord-010119-t1x9gknd 6986 2 ( ( -LRB- cord-010119-t1x9gknd 6986 3 p p NN cord-010119-t1x9gknd 6986 4 . . . cord-010119-t1x9gknd 6986 5 Thr379Met thr379met CD cord-010119-t1x9gknd 6986 6 ) ) -RRB- cord-010119-t1x9gknd 6987 1 characteristic characteristic NN cord-010119-t1x9gknd 6987 2 of of IN cord-010119-t1x9gknd 6987 3 the the DT cord-010119-t1x9gknd 6987 4 African african JJ cord-010119-t1x9gknd 6987 5 DAU dau NN cord-010119-t1x9gknd 6987 6 cluster cluster NN cord-010119-t1x9gknd 6987 7 . . . cord-010119-t1x9gknd 6988 1 D D NNP cord-010119-t1x9gknd 6988 2 antigen antigen NN cord-010119-t1x9gknd 6988 3 associated associate VBN cord-010119-t1x9gknd 6988 4 with with IN cord-010119-t1x9gknd 6988 5 p.263Leu p.263Leu NNP cord-010119-t1x9gknd 6988 6 is be VBZ cord-010119-t1x9gknd 6988 7 a a DT cord-010119-t1x9gknd 6988 8 partial partial JJ cord-010119-t1x9gknd 6988 9 D d NN cord-010119-t1x9gknd 6988 10 antigen antigen NN cord-010119-t1x9gknd 6988 11 with with IN cord-010119-t1x9gknd 6988 12 a a DT cord-010119-t1x9gknd 6988 13 novel novel JJ cord-010119-t1x9gknd 6988 14 epitope epitope NN cord-010119-t1x9gknd 6988 15 pattern pattern NN cord-010119-t1x9gknd 6988 16 . . . cord-010119-t1x9gknd 6989 1 The the DT cord-010119-t1x9gknd 6989 2 p.254Leu p.254leu JJ cord-010119-t1x9gknd 6989 3 change change NN cord-010119-t1x9gknd 6989 4 is be VBZ cord-010119-t1x9gknd 6989 5 associated associate VBN cord-010119-t1x9gknd 6989 6 with with IN cord-010119-t1x9gknd 6989 7 a a DT cord-010119-t1x9gknd 6989 8 Del Del NNP cord-010119-t1x9gknd 6989 9 - - HYPH cord-010119-t1x9gknd 6989 10 like like JJ cord-010119-t1x9gknd 6989 11 phenotype phenotype NN cord-010119-t1x9gknd 6989 12 , , , cord-010119-t1x9gknd 6989 13 the the DT cord-010119-t1x9gknd 6989 14 first first RB cord-010119-t1x9gknd 6989 15 observed observe VBD cord-010119-t1x9gknd 6989 16 to to IN cord-010119-t1x9gknd 6989 17 our -PRON- PRP$ cord-010119-t1x9gknd 6989 18 knowledge knowledge NN cord-010119-t1x9gknd 6989 19 for for IN cord-010119-t1x9gknd 6989 20 a a DT cord-010119-t1x9gknd 6989 21 DAU dau NN cord-010119-t1x9gknd 6989 22 allele allele NN cord-010119-t1x9gknd 6989 23 , , , cord-010119-t1x9gknd 6989 24 and and CC cord-010119-t1x9gknd 6989 25 D D NNP cord-010119-t1x9gknd 6989 26 antigen antigen NN cord-010119-t1x9gknd 6989 27 on on IN cord-010119-t1x9gknd 6989 28 the the DT cord-010119-t1x9gknd 6989 29 RBCs rbc NNS cord-010119-t1x9gknd 6989 30 is be VBZ cord-010119-t1x9gknd 6989 31 not not RB cord-010119-t1x9gknd 6989 32 detected detect VBN cord-010119-t1x9gknd 6989 33 in in IN cord-010119-t1x9gknd 6989 34 IAT IAT NNP cord-010119-t1x9gknd 6989 35 by by IN cord-010119-t1x9gknd 6989 36 5/7 5/7 CD cord-010119-t1x9gknd 6990 1 commercial commercial NNP cord-010119-t1x9gknd 6990 2 anti anti NNP cord-010119-t1x9gknd 6990 3 - - NNP cord-010119-t1x9gknd 6990 4 D. D. NNP cord-010119-t1x9gknd 6991 1 The the DT cord-010119-t1x9gknd 6991 2 RHD RHD NNP cord-010119-t1x9gknd 6991 3 nucleotide nucleotide NN cord-010119-t1x9gknd 6991 4 changes change NNS cord-010119-t1x9gknd 6991 5 reported report VBN cord-010119-t1x9gknd 6991 6 here here RB cord-010119-t1x9gknd 6991 7 are be VBP cord-010119-t1x9gknd 6991 8 not not RB cord-010119-t1x9gknd 6991 9 in in IN cord-010119-t1x9gknd 6991 10 dbSNP dbSNP NNP cord-010119-t1x9gknd 6991 11 database database NN cord-010119-t1x9gknd 6991 12 . . . cord-010119-t1x9gknd 6992 1 This this DT cord-010119-t1x9gknd 6992 2 study study NN cord-010119-t1x9gknd 6992 3 brings bring VBZ cord-010119-t1x9gknd 6992 4 the the DT cord-010119-t1x9gknd 6992 5 DAU dau NN cord-010119-t1x9gknd 6992 6 family family NN cord-010119-t1x9gknd 6992 7 of of IN cord-010119-t1x9gknd 6992 8 alleles allele NNS cord-010119-t1x9gknd 6992 9 to to IN cord-010119-t1x9gknd 6992 10 21 21 CD cord-010119-t1x9gknd 6992 11 . . . cord-010119-t1x9gknd 6993 1 The the DT cord-010119-t1x9gknd 6993 2 number number NN cord-010119-t1x9gknd 6993 3 and and CC cord-010119-t1x9gknd 6993 4 diversity diversity NN cord-010119-t1x9gknd 6993 5 of of IN cord-010119-t1x9gknd 6993 6 alleles allele NNS cord-010119-t1x9gknd 6993 7 in in IN cord-010119-t1x9gknd 6993 8 the the DT cord-010119-t1x9gknd 6993 9 DAU dau NN cord-010119-t1x9gknd 6993 10 cluster cluster NN cord-010119-t1x9gknd 6993 11 supports support VBZ cord-010119-t1x9gknd 6993 12 that that IN cord-010119-t1x9gknd 6993 13 the the DT cord-010119-t1x9gknd 6993 14 c.1136C c.1136c CD cord-010119-t1x9gknd 6994 1 > > XX cord-010119-t1x9gknd 6995 1 T T NNP cord-010119-t1x9gknd 6995 2 change change NN cord-010119-t1x9gknd 6995 3 is be VBZ cord-010119-t1x9gknd 6995 4 a a DT cord-010119-t1x9gknd 6995 5 major major JJ cord-010119-t1x9gknd 6995 6 ancestral ancestral JJ cord-010119-t1x9gknd 6995 7 African african JJ cord-010119-t1x9gknd 6995 8 background background NN cord-010119-t1x9gknd 6995 9 allele allele NN cord-010119-t1x9gknd 6995 10 ( ( -LRB- cord-010119-t1x9gknd 6995 11 Wagner Wagner NNP cord-010119-t1x9gknd 6995 12 et et NNP cord-010119-t1x9gknd 6995 13 al al NNP cord-010119-t1x9gknd 6995 14 , , , cord-010119-t1x9gknd 6995 15 Blood blood NN cord-010119-t1x9gknd 6995 16 2002,100:306 2002,100:306 CD cord-010119-t1x9gknd 6995 17 ) ) -RRB- cord-010119-t1x9gknd 6995 18 . . . cord-010119-t1x9gknd 6996 1 Tae Tae NNP cord-010119-t1x9gknd 6996 2 Eun Eun NNP cord-010119-t1x9gknd 6996 3 Kim Kim NNP cord-010119-t1x9gknd 6997 1 * * NFP cord-010119-t1x9gknd 6997 2 . . . cord-010119-t1x9gknd 6998 1 KRC KRC NNP cord-010119-t1x9gknd 6998 2 BTRI BTRI NNP cord-010119-t1x9gknd 6998 3 Background Background NNP cord-010119-t1x9gknd 6998 4 / / SYM cord-010119-t1x9gknd 6998 5 Case Case NNP cord-010119-t1x9gknd 6998 6 Studies Studies NNPS cord-010119-t1x9gknd 6998 7 : : : cord-010119-t1x9gknd 6999 1 There there EX cord-010119-t1x9gknd 6999 2 have have VBP cord-010119-t1x9gknd 6999 3 been be VBN cord-010119-t1x9gknd 6999 4 the the DT cord-010119-t1x9gknd 6999 5 cases case NNS cord-010119-t1x9gknd 6999 6 of of IN cord-010119-t1x9gknd 6999 7 anti anti JJ cord-010119-t1x9gknd 6999 8 - - JJ cord-010119-t1x9gknd 6999 9 D d JJ cord-010119-t1x9gknd 6999 10 alloimmunization alloimmunization NN cord-010119-t1x9gknd 6999 11 caused cause VBN cord-010119-t1x9gknd 6999 12 by by IN cord-010119-t1x9gknd 6999 13 the the DT cord-010119-t1x9gknd 6999 14 transfusion transfusion NN cord-010119-t1x9gknd 6999 15 of of IN cord-010119-t1x9gknd 6999 16 serologically serologically RB cord-010119-t1x9gknd 6999 17 D d JJ cord-010119-t1x9gknd 6999 18 negative negative JJ cord-010119-t1x9gknd 6999 19 blood blood NN cord-010119-t1x9gknd 6999 20 component component NN cord-010119-t1x9gknd 6999 21 . . . cord-010119-t1x9gknd 7000 1 By by IN cord-010119-t1x9gknd 7000 2 analysis analysis NN cord-010119-t1x9gknd 7000 3 of of IN cord-010119-t1x9gknd 7000 4 genotype genotype NN cord-010119-t1x9gknd 7000 5 of of IN cord-010119-t1x9gknd 7000 6 the the DT cord-010119-t1x9gknd 7000 7 blood blood NN cord-010119-t1x9gknd 7000 8 component component NN cord-010119-t1x9gknd 7000 9 , , , cord-010119-t1x9gknd 7000 10 all all DT cord-010119-t1x9gknd 7000 11 of of IN cord-010119-t1x9gknd 7000 12 them -PRON- PRP cord-010119-t1x9gknd 7000 13 were be VBD cord-010119-t1x9gknd 7000 14 confirmed confirm VBN cord-010119-t1x9gknd 7000 15 as as IN cord-010119-t1x9gknd 7000 16 Asian asian JJ cord-010119-t1x9gknd 7000 17 type type NN cord-010119-t1x9gknd 7000 18 DEL DEL NNP cord-010119-t1x9gknd 7000 19 . . . cord-010119-t1x9gknd 7001 1 For for IN cord-010119-t1x9gknd 7001 2 that that DT cord-010119-t1x9gknd 7001 3 reason reason NN cord-010119-t1x9gknd 7001 4 , , , cord-010119-t1x9gknd 7001 5 the the DT cord-010119-t1x9gknd 7001 6 application application NN cord-010119-t1x9gknd 7001 7 of of IN cord-010119-t1x9gknd 7001 8 genetic genetic JJ cord-010119-t1x9gknd 7001 9 analysis analysis NN cord-010119-t1x9gknd 7001 10 for for IN cord-010119-t1x9gknd 7001 11 the the DT cord-010119-t1x9gknd 7001 12 blood blood NN cord-010119-t1x9gknd 7001 13 donor donor NN cord-010119-t1x9gknd 7001 14 has have VBZ cord-010119-t1x9gknd 7001 15 been be VBN cord-010119-t1x9gknd 7001 16 required require VBN cord-010119-t1x9gknd 7001 17 in in IN cord-010119-t1x9gknd 7001 18 addition addition NN cord-010119-t1x9gknd 7001 19 to to IN cord-010119-t1x9gknd 7001 20 serological serological JJ cord-010119-t1x9gknd 7001 21 assay assay NN cord-010119-t1x9gknd 7001 22 . . . cord-010119-t1x9gknd 7002 1 We -PRON- PRP cord-010119-t1x9gknd 7002 2 established establish VBD cord-010119-t1x9gknd 7002 3 the the DT cord-010119-t1x9gknd 7002 4 algorithm algorithm NN cord-010119-t1x9gknd 7002 5 for for IN cord-010119-t1x9gknd 7002 6 the the DT cord-010119-t1x9gknd 7002 7 genetic genetic JJ cord-010119-t1x9gknd 7002 8 analysis analysis NN cord-010119-t1x9gknd 7002 9 of of IN cord-010119-t1x9gknd 7002 10 RHDin RHDin NNP cord-010119-t1x9gknd 7002 11 blood blood NN cord-010119-t1x9gknd 7002 12 donors donor NNS cord-010119-t1x9gknd 7002 13 . . . cord-010119-t1x9gknd 7003 1 In in IN cord-010119-t1x9gknd 7003 2 this this DT cord-010119-t1x9gknd 7003 3 study study NN cord-010119-t1x9gknd 7003 4 , , , cord-010119-t1x9gknd 7003 5 we -PRON- PRP cord-010119-t1x9gknd 7003 6 would would MD cord-010119-t1x9gknd 7003 7 introduce introduce VB cord-010119-t1x9gknd 7003 8 the the DT cord-010119-t1x9gknd 7003 9 experience experience NN cord-010119-t1x9gknd 7003 10 of of IN cord-010119-t1x9gknd 7003 11 the the DT cord-010119-t1x9gknd 7003 12 application application NN cord-010119-t1x9gknd 7003 13 of of IN cord-010119-t1x9gknd 7003 14 the the DT cord-010119-t1x9gknd 7003 15 algorithm algorithm NN cord-010119-t1x9gknd 7003 16 and and CC cord-010119-t1x9gknd 7003 17 the the DT cord-010119-t1x9gknd 7003 18 results result NNS cord-010119-t1x9gknd 7003 19 in in IN cord-010119-t1x9gknd 7003 20 the the DT cord-010119-t1x9gknd 7003 21 preliminary preliminary JJ cord-010119-t1x9gknd 7003 22 test test NN cord-010119-t1x9gknd 7003 23 . . . cord-010119-t1x9gknd 7004 1 Study Study NNP cord-010119-t1x9gknd 7004 2 Design Design NNP cord-010119-t1x9gknd 7004 3 / / SYM cord-010119-t1x9gknd 7004 4 Method method NN cord-010119-t1x9gknd 7004 5 : : : cord-010119-t1x9gknd 7005 1 From from IN cord-010119-t1x9gknd 7005 2 September September NNP cord-010119-t1x9gknd 7005 3 2016 2016 CD cord-010119-t1x9gknd 7005 4 to to TO cord-010119-t1x9gknd 7005 5 present present JJ cord-010119-t1x9gknd 7005 6 day day NN cord-010119-t1x9gknd 7005 7 we -PRON- PRP cord-010119-t1x9gknd 7005 8 got get VBD cord-010119-t1x9gknd 7005 9 130 130 CD cord-010119-t1x9gknd 7005 10 samples sample NNS cord-010119-t1x9gknd 7005 11 of of IN cord-010119-t1x9gknd 7005 12 repeated repeat VBN cord-010119-t1x9gknd 7005 13 blood blood NN cord-010119-t1x9gknd 7005 14 donors donor NNS cord-010119-t1x9gknd 7005 15 who who WP cord-010119-t1x9gknd 7005 16 are be VBP cord-010119-t1x9gknd 7005 17 known know VBN cord-010119-t1x9gknd 7005 18 to to TO cord-010119-t1x9gknd 7005 19 be be VB cord-010119-t1x9gknd 7005 20 D D NNP cord-010119-t1x9gknd 7005 21 negative negative JJ cord-010119-t1x9gknd 7005 22 , , , cord-010119-t1x9gknd 7005 23 C C NNP cord-010119-t1x9gknd 7005 24 positive positive JJ cord-010119-t1x9gknd 7006 1 and/or and/or CC cord-010119-t1x9gknd 7006 2 E e NN cord-010119-t1x9gknd 7006 3 negative negative JJ cord-010119-t1x9gknd 7006 4 from from IN cord-010119-t1x9gknd 7006 5 15 15 CD cord-010119-t1x9gknd 7006 6 blood blood NN cord-010119-t1x9gknd 7006 7 centers center NNS cord-010119-t1x9gknd 7006 8 . . . cord-010119-t1x9gknd 7007 1 We -PRON- PRP cord-010119-t1x9gknd 7007 2 obtained obtain VBD cord-010119-t1x9gknd 7007 3 the the DT cord-010119-t1x9gknd 7007 4 consent consent NN cord-010119-t1x9gknd 7007 5 for for IN cord-010119-t1x9gknd 7007 6 the the DT cord-010119-t1x9gknd 7007 7 test test NN cord-010119-t1x9gknd 7007 8 from from IN cord-010119-t1x9gknd 7007 9 all all DT cord-010119-t1x9gknd 7007 10 of of IN cord-010119-t1x9gknd 7007 11 the the DT cord-010119-t1x9gknd 7007 12 donors donor NNS cord-010119-t1x9gknd 7007 13 who who WP cord-010119-t1x9gknd 7007 14 provided provide VBD cord-010119-t1x9gknd 7007 15 samples sample NNS cord-010119-t1x9gknd 7007 16 . . . cord-010119-t1x9gknd 7008 1 As as IN cord-010119-t1x9gknd 7008 2 a a DT cord-010119-t1x9gknd 7008 3 genetic genetic JJ cord-010119-t1x9gknd 7008 4 analysis analysis NN cord-010119-t1x9gknd 7008 5 , , , cord-010119-t1x9gknd 7008 6 we -PRON- PRP cord-010119-t1x9gknd 7008 7 accomplished accomplish VBD cord-010119-t1x9gknd 7008 8 polymerase polymerase NN cord-010119-t1x9gknd 7008 9 chain chain NN cord-010119-t1x9gknd 7008 10 reaction reaction NN cord-010119-t1x9gknd 7008 11 with with IN cord-010119-t1x9gknd 7008 12 sequence sequence NN cord-010119-t1x9gknd 7008 13 - - HYPH cord-010119-t1x9gknd 7008 14 specific specific JJ cord-010119-t1x9gknd 7008 15 primers primer NNS cord-010119-t1x9gknd 7008 16 ( ( -LRB- cord-010119-t1x9gknd 7008 17 PCR PCR NNP cord-010119-t1x9gknd 7008 18 - - HYPH cord-010119-t1x9gknd 7008 19 SSP SSP NNP cord-010119-t1x9gknd 7008 20 ) ) -RRB- cord-010119-t1x9gknd 7008 21 for for IN cord-010119-t1x9gknd 7008 22 the the DT cord-010119-t1x9gknd 7008 23 region region NN cord-010119-t1x9gknd 7008 24 of of IN cord-010119-t1x9gknd 7008 25 promoter promoter NN cord-010119-t1x9gknd 7008 26 , , , cord-010119-t1x9gknd 7008 27 exon exon NN cord-010119-t1x9gknd 7008 28 4 4 CD cord-010119-t1x9gknd 7008 29 , , , cord-010119-t1x9gknd 7008 30 exon exon NN cord-010119-t1x9gknd 7008 31 7 7 CD cord-010119-t1x9gknd 7008 32 and and CC cord-010119-t1x9gknd 7008 33 exon exon NN cord-010119-t1x9gknd 7008 34 10 10 CD cord-010119-t1x9gknd 7008 35 in in IN cord-010119-t1x9gknd 7008 36 RHD RHD NNP cord-010119-t1x9gknd 7008 37 gene gene NN cord-010119-t1x9gknd 7008 38 . . . cord-010119-t1x9gknd 7009 1 Based base VBN cord-010119-t1x9gknd 7009 2 on on IN cord-010119-t1x9gknd 7009 3 the the DT cord-010119-t1x9gknd 7009 4 results result NNS cord-010119-t1x9gknd 7009 5 of of IN cord-010119-t1x9gknd 7009 6 PCR PCR NNP cord-010119-t1x9gknd 7009 7 - - HYPH cord-010119-t1x9gknd 7009 8 SSP SSP NNP cord-010119-t1x9gknd 7009 9 , , , cord-010119-t1x9gknd 7009 10 we -PRON- PRP cord-010119-t1x9gknd 7009 11 discriminated discriminate VBD cord-010119-t1x9gknd 7009 12 the the DT cord-010119-t1x9gknd 7009 13 results result NNS cord-010119-t1x9gknd 7009 14 into into IN cord-010119-t1x9gknd 7009 15 total total JJ cord-010119-t1x9gknd 7009 16 RHD RHD NNP cord-010119-t1x9gknd 7009 17 deletion deletion NN cord-010119-t1x9gknd 7009 18 , , , cord-010119-t1x9gknd 7009 19 RHD RHD NNP cord-010119-t1x9gknd 7009 20 - - HYPH cord-010119-t1x9gknd 7009 21 CE CE NNP cord-010119-t1x9gknd 7009 22 - - HYPH cord-010119-t1x9gknd 7009 23 D d JJ cord-010119-t1x9gknd 7009 24 hybrid hybrid NN cord-010119-t1x9gknd 7009 25 and and CC cord-010119-t1x9gknd 7009 26 RHD RHD NNP cord-010119-t1x9gknd 7009 27 variant variant NN cord-010119-t1x9gknd 7009 28 . . . cord-010119-t1x9gknd 7010 1 When when WRB cord-010119-t1x9gknd 7010 2 the the DT cord-010119-t1x9gknd 7010 3 results result NNS cord-010119-t1x9gknd 7010 4 were be VBD cord-010119-t1x9gknd 7010 5 discriminated discriminate VBN cord-010119-t1x9gknd 7010 6 to to TO cord-010119-t1x9gknd 7010 7 be be VB cord-010119-t1x9gknd 7010 8 RHD RHD NNP cord-010119-t1x9gknd 7010 9 variant variant NN cord-010119-t1x9gknd 7010 10 , , , cord-010119-t1x9gknd 7010 11 we -PRON- PRP cord-010119-t1x9gknd 7010 12 additionally additionally RB cord-010119-t1x9gknd 7010 13 analyzed analyze VBD cord-010119-t1x9gknd 7010 14 the the DT cord-010119-t1x9gknd 7010 15 sequence sequence NN cord-010119-t1x9gknd 7010 16 of of IN cord-010119-t1x9gknd 7010 17 exon exon NN cord-010119-t1x9gknd 7010 18 9 9 CD cord-010119-t1x9gknd 7010 19 to to TO cord-010119-t1x9gknd 7010 20 confirm confirm VB cord-010119-t1x9gknd 7010 21 the the DT cord-010119-t1x9gknd 7010 22 existence existence NN cord-010119-t1x9gknd 7010 23 of of IN cord-010119-t1x9gknd 7010 24 c.1227 c.1227 NN cord-010119-t1x9gknd 7010 25 G g NN cord-010119-t1x9gknd 7011 1 > > XX cord-010119-t1x9gknd 7012 1 A a NN cord-010119-t1x9gknd 7012 2 and and CC cord-010119-t1x9gknd 7012 3 c.1222T c.1222t NN cord-010119-t1x9gknd 7012 4 > > XX cord-010119-t1x9gknd 7012 5 A a DT cord-010119-t1x9gknd 7012 6 variations variation NNS cord-010119-t1x9gknd 7012 7 . . . cord-010119-t1x9gknd 7013 1 For for IN cord-010119-t1x9gknd 7013 2 the the DT cord-010119-t1x9gknd 7013 3 sample sample NN cord-010119-t1x9gknd 7013 4 with with IN cord-010119-t1x9gknd 7013 5 indeterminate indeterminate JJ cord-010119-t1x9gknd 7013 6 results result NNS cord-010119-t1x9gknd 7013 7 , , , cord-010119-t1x9gknd 7013 8 we -PRON- PRP cord-010119-t1x9gknd 7013 9 performed perform VBD cord-010119-t1x9gknd 7013 10 sequencing sequence VBG cord-010119-t1x9gknd 7013 11 for for IN cord-010119-t1x9gknd 7013 12 the the DT cord-010119-t1x9gknd 7013 13 full full JJ cord-010119-t1x9gknd 7013 14 region region NN cord-010119-t1x9gknd 7013 15 of of IN cord-010119-t1x9gknd 7013 16 exon exon NN cord-010119-t1x9gknd 7013 17 . . . cord-010119-t1x9gknd 7014 1 When when WRB cord-010119-t1x9gknd 7014 2 the the DT cord-010119-t1x9gknd 7014 3 result result NN cord-010119-t1x9gknd 7014 4 was be VBD cord-010119-t1x9gknd 7014 5 confirmed confirm VBN cord-010119-t1x9gknd 7014 6 to to TO cord-010119-t1x9gknd 7014 7 be be VB cord-010119-t1x9gknd 7014 8 RHD RHD NNP cord-010119-t1x9gknd 7014 9 deletion deletion NN cord-010119-t1x9gknd 7014 10 or or CC cord-010119-t1x9gknd 7014 11 RHD RHD NNP cord-010119-t1x9gknd 7014 12 - - HYPH cord-010119-t1x9gknd 7014 13 CE CE NNP cord-010119-t1x9gknd 7014 14 - - HYPH cord-010119-t1x9gknd 7014 15 D d JJ cord-010119-t1x9gknd 7014 16 hybrid hybrid NN cord-010119-t1x9gknd 7014 17 , , , cord-010119-t1x9gknd 7014 18 the the DT cord-010119-t1x9gknd 7014 19 blood blood NN cord-010119-t1x9gknd 7014 20 components component NNS cord-010119-t1x9gknd 7014 21 were be VBD cord-010119-t1x9gknd 7014 22 regarded regard VBN cord-010119-t1x9gknd 7014 23 as as IN cord-010119-t1x9gknd 7014 24 RhD rhd NN cord-010119-t1x9gknd 7014 25 negative negative JJ cord-010119-t1x9gknd 7014 26 . . . cord-010119-t1x9gknd 7015 1 When when WRB cord-010119-t1x9gknd 7015 2 the the DT cord-010119-t1x9gknd 7015 3 result result NN cord-010119-t1x9gknd 7015 4 was be VBD cord-010119-t1x9gknd 7015 5 confirmed confirm VBN cord-010119-t1x9gknd 7015 6 to to TO cord-010119-t1x9gknd 7015 7 be be VB cord-010119-t1x9gknd 7015 8 RHDvariant rhdvariant JJ cord-010119-t1x9gknd 7015 9 , , , cord-010119-t1x9gknd 7015 10 the the DT cord-010119-t1x9gknd 7015 11 blood blood NN cord-010119-t1x9gknd 7015 12 components component NNS cord-010119-t1x9gknd 7015 13 were be VBD cord-010119-t1x9gknd 7015 14 regarded regard VBN cord-010119-t1x9gknd 7015 15 as as IN cord-010119-t1x9gknd 7015 16 RhD rhd NN cord-010119-t1x9gknd 7015 17 positive positive JJ cord-010119-t1x9gknd 7015 18 . . . cord-010119-t1x9gknd 7016 1 Blood blood NN cord-010119-t1x9gknd 7016 2 components component NNS cord-010119-t1x9gknd 7016 3 were be VBD cord-010119-t1x9gknd 7016 4 not not RB cord-010119-t1x9gknd 7016 5 supplied supply VBN cord-010119-t1x9gknd 7016 6 until until IN cord-010119-t1x9gknd 7016 7 the the DT cord-010119-t1x9gknd 7016 8 final final JJ cord-010119-t1x9gknd 7016 9 results result NNS cord-010119-t1x9gknd 7016 10 were be VBD cord-010119-t1x9gknd 7016 11 obtained obtain VBN cord-010119-t1x9gknd 7016 12 . . . cord-010119-t1x9gknd 7017 1 Results result NNS cord-010119-t1x9gknd 7017 2 / / SYM cord-010119-t1x9gknd 7017 3 Finding finding NN cord-010119-t1x9gknd 7017 4 : : : cord-010119-t1x9gknd 7018 1 For for IN cord-010119-t1x9gknd 7018 2 the the DT cord-010119-t1x9gknd 7018 3 130 130 CD cord-010119-t1x9gknd 7018 4 sample sample NN cord-010119-t1x9gknd 7018 5 , , , cord-010119-t1x9gknd 7018 6 we -PRON- PRP cord-010119-t1x9gknd 7018 7 identified identify VBD cord-010119-t1x9gknd 7018 8 71 71 CD cord-010119-t1x9gknd 7018 9 cases case NNS cord-010119-t1x9gknd 7018 10 ( ( -LRB- cord-010119-t1x9gknd 7018 11 54.6 54.6 CD cord-010119-t1x9gknd 7018 12 % % NN cord-010119-t1x9gknd 7018 13 ) ) -RRB- cord-010119-t1x9gknd 7018 14 of of IN cord-010119-t1x9gknd 7018 15 total total JJ cord-010119-t1x9gknd 7018 16 RHD RHD NNP cord-010119-t1x9gknd 7018 17 deletion deletion NN cord-010119-t1x9gknd 7018 18 , , , cord-010119-t1x9gknd 7018 19 18 18 CD cord-010119-t1x9gknd 7018 20 cases case NNS cord-010119-t1x9gknd 7018 21 ( ( -LRB- cord-010119-t1x9gknd 7018 22 13.8 13.8 CD cord-010119-t1x9gknd 7018 23 % % NN cord-010119-t1x9gknd 7018 24 ) ) -RRB- cord-010119-t1x9gknd 7018 25 of of IN cord-010119-t1x9gknd 7018 26 RHD RHD NNP cord-010119-t1x9gknd 7018 27 - - HYPH cord-010119-t1x9gknd 7018 28 CE CE NNP cord-010119-t1x9gknd 7018 29 - - HYPH cord-010119-t1x9gknd 7018 30 D d JJ cord-010119-t1x9gknd 7018 31 hybrid hybrid NN cord-010119-t1x9gknd 7018 32 , , , cord-010119-t1x9gknd 7018 33 and and CC cord-010119-t1x9gknd 7018 34 41 41 CD cord-010119-t1x9gknd 7018 35 cases case NNS cord-010119-t1x9gknd 7018 36 ( ( -LRB- cord-010119-t1x9gknd 7018 37 31.5 31.5 CD cord-010119-t1x9gknd 7018 38 % % NN cord-010119-t1x9gknd 7018 39 ) ) -RRB- cord-010119-t1x9gknd 7018 40 of of IN cord-010119-t1x9gknd 7018 41 RHD RHD NNP cord-010119-t1x9gknd 7018 42 variant variant NN cord-010119-t1x9gknd 7018 43 . . . cord-010119-t1x9gknd 7019 1 39 39 CD cord-010119-t1x9gknd 7019 2 of of IN cord-010119-t1x9gknd 7019 3 RHD RHD NNP cord-010119-t1x9gknd 7019 4 variant variant NN cord-010119-t1x9gknd 7019 5 were be VBD cord-010119-t1x9gknd 7019 6 determined determine VBN cord-010119-t1x9gknd 7019 7 to to TO cord-010119-t1x9gknd 7019 8 be be VB cord-010119-t1x9gknd 7019 9 Asian asian JJ cord-010119-t1x9gknd 7019 10 type type NN cord-010119-t1x9gknd 7019 11 DEL DEL NNP cord-010119-t1x9gknd 7019 12 with with IN cord-010119-t1x9gknd 7019 13 c.1227 c.1227 NN cord-010119-t1x9gknd 7019 14 G g NN cord-010119-t1x9gknd 7020 1 > > XX cord-010119-t1x9gknd 7021 1 A a DT cord-010119-t1x9gknd 7021 2 variation variation NN cord-010119-t1x9gknd 7021 3 . . . cord-010119-t1x9gknd 7022 1 2 2 CD cord-010119-t1x9gknd 7022 2 cases case NNS cord-010119-t1x9gknd 7022 3 of of IN cord-010119-t1x9gknd 7022 4 RHDvariant rhdvariant JJ cord-010119-t1x9gknd 7022 5 were be VBD cord-010119-t1x9gknd 7022 6 regarded regard VBN cord-010119-t1x9gknd 7022 7 to to TO cord-010119-t1x9gknd 7022 8 be be VB cord-010119-t1x9gknd 7022 9 unknown unknown JJ cord-010119-t1x9gknd 7022 10 variation variation NN cord-010119-t1x9gknd 7022 11 . . . cord-010119-t1x9gknd 7023 1 Conclusion conclusion NN cord-010119-t1x9gknd 7023 2 : : : cord-010119-t1x9gknd 7024 1 The the DT cord-010119-t1x9gknd 7024 2 frequency frequency NN cord-010119-t1x9gknd 7024 3 of of IN cord-010119-t1x9gknd 7024 4 RHD RHD NNP cord-010119-t1x9gknd 7024 5 variant variant NN cord-010119-t1x9gknd 7024 6 in in IN cord-010119-t1x9gknd 7024 7 this this DT cord-010119-t1x9gknd 7024 8 study study NN cord-010119-t1x9gknd 7024 9 was be VBD cord-010119-t1x9gknd 7024 10 10 10 CD cord-010119-t1x9gknd 7024 11 % % NN cord-010119-t1x9gknd 7024 12 higher high JJR cord-010119-t1x9gknd 7024 13 than than IN cord-010119-t1x9gknd 7024 14 that that DT cord-010119-t1x9gknd 7024 15 of of IN cord-010119-t1x9gknd 7024 16 the the DT cord-010119-t1x9gknd 7024 17 general general JJ cord-010119-t1x9gknd 7024 18 D D NNP cord-010119-t1x9gknd 7024 19 negative negative JJ cord-010119-t1x9gknd 7024 20 donors donor NNS cord-010119-t1x9gknd 7024 21 not not RB cord-010119-t1x9gknd 7024 22 considering consider VBG cord-010119-t1x9gknd 7024 23 RhCE rhce NN cord-010119-t1x9gknd 7024 24 phenotype phenotype NN cord-010119-t1x9gknd 7024 25 in in IN cord-010119-t1x9gknd 7024 26 a a DT cord-010119-t1x9gknd 7024 27 previous previous JJ cord-010119-t1x9gknd 7024 28 study study NN cord-010119-t1x9gknd 7024 29 . . . cord-010119-t1x9gknd 7025 1 For for IN cord-010119-t1x9gknd 7025 2 that that DT cord-010119-t1x9gknd 7025 3 reason reason NN cord-010119-t1x9gknd 7025 4 , , , cord-010119-t1x9gknd 7025 5 we -PRON- PRP cord-010119-t1x9gknd 7025 6 considered consider VBD cord-010119-t1x9gknd 7025 7 that that IN cord-010119-t1x9gknd 7025 8 the the DT cord-010119-t1x9gknd 7025 9 genetic genetic JJ cord-010119-t1x9gknd 7025 10 analysis analysis NN cord-010119-t1x9gknd 7025 11 of of IN cord-010119-t1x9gknd 7025 12 RHD RHD NNP cord-010119-t1x9gknd 7025 13 targeting target VBG cord-010119-t1x9gknd 7025 14 the the DT cord-010119-t1x9gknd 7025 15 donors donor NNS cord-010119-t1x9gknd 7025 16 of of IN cord-010119-t1x9gknd 7025 17 D D NNP cord-010119-t1x9gknd 7025 18 negative negative JJ cord-010119-t1x9gknd 7025 19 , , , cord-010119-t1x9gknd 7025 20 C C NNP cord-010119-t1x9gknd 7025 21 positive positive JJ cord-010119-t1x9gknd 7025 22 and/or and/or CC cord-010119-t1x9gknd 7025 23 E e NN cord-010119-t1x9gknd 7025 24 negative negative JJ cord-010119-t1x9gknd 7025 25 is be VBZ cord-010119-t1x9gknd 7025 26 more more RBR cord-010119-t1x9gknd 7025 27 efficient efficient JJ cord-010119-t1x9gknd 7025 28 approach approach NN cord-010119-t1x9gknd 7025 29 to to TO cord-010119-t1x9gknd 7025 30 identify identify VB cord-010119-t1x9gknd 7025 31 RHD RHD NNP cord-010119-t1x9gknd 7025 32 variant variant NN cord-010119-t1x9gknd 7025 33 and and CC cord-010119-t1x9gknd 7025 34 better well JJR cord-010119-t1x9gknd 7025 35 way way NN cord-010119-t1x9gknd 7025 36 to to TO cord-010119-t1x9gknd 7025 37 improve improve VB cord-010119-t1x9gknd 7025 38 blood blood NN cord-010119-t1x9gknd 7025 39 safety safety NN cord-010119-t1x9gknd 7025 40 in in IN cord-010119-t1x9gknd 7025 41 the the DT cord-010119-t1x9gknd 7025 42 transfusion transfusion NN cord-010119-t1x9gknd 7025 43 medicine medicine NN cord-010119-t1x9gknd 7025 44 related relate VBN cord-010119-t1x9gknd 7025 45 with with IN cord-010119-t1x9gknd 7025 46 RhD rhd NN cord-010119-t1x9gknd 7025 47 negative negative JJ cord-010119-t1x9gknd 7025 48 blood blood NN cord-010119-t1x9gknd 7025 49 donors donor NNS cord-010119-t1x9gknd 7025 50 . . . cord-010119-t1x9gknd 7026 1 Lei Lei NNP cord-010119-t1x9gknd 7026 2 Fang Fang NNP cord-010119-t1x9gknd 7026 3 Tsai Tsai NNP cord-010119-t1x9gknd 7026 4 * * NFP cord-010119-t1x9gknd 7026 5 , , , cord-010119-t1x9gknd 7026 6 Ping Ping NNP cord-010119-t1x9gknd 7026 7 Chun Chun NNP cord-010119-t1x9gknd 7026 8 Wu Wu NNP cord-010119-t1x9gknd 7026 9 , , , cord-010119-t1x9gknd 7026 10 Shu Shu NNP cord-010119-t1x9gknd 7026 11 Hui Hui NNP cord-010119-t1x9gknd 7026 12 Feng Feng NNP cord-010119-t1x9gknd 7026 13 , , , cord-010119-t1x9gknd 7026 14 Yi Yi NNP cord-010119-t1x9gknd 7026 15 Wen Wen NNP cord-010119-t1x9gknd 7026 16 Tsai Tsai NNP cord-010119-t1x9gknd 7026 17 , , , cord-010119-t1x9gknd 7026 18 Ming Ming NNP cord-010119-t1x9gknd 7026 19 Hung Hung NNP cord-010119-t1x9gknd 7026 20 Chen Chen NNP cord-010119-t1x9gknd 7026 21 and and CC cord-010119-t1x9gknd 7026 22 Shun Shun NNP cord-010119-t1x9gknd 7026 23 Chung Chung NNP cord-010119-t1x9gknd 7026 24 Pai Pai NNP cord-010119-t1x9gknd 7026 25 . . . cord-010119-t1x9gknd 7027 1 Taipei Taipei NNP cord-010119-t1x9gknd 7027 2 Blood Blood NNP cord-010119-t1x9gknd 7027 3 Center Center NNP cord-010119-t1x9gknd 7027 4 , , , cord-010119-t1x9gknd 7027 5 Taiwan Taiwan NNP cord-010119-t1x9gknd 7027 6 Blood Blood NNP cord-010119-t1x9gknd 7027 7 Services Services NNPS cord-010119-t1x9gknd 7027 8 Foundation Foundation NNP cord-010119-t1x9gknd 7027 9 Background Background NNP cord-010119-t1x9gknd 7027 10 / / SYM cord-010119-t1x9gknd 7027 11 Case Case NNP cord-010119-t1x9gknd 7027 12 Studies Studies NNPS cord-010119-t1x9gknd 7027 13 : : : cord-010119-t1x9gknd 7027 14 Certain certain JJ cord-010119-t1x9gknd 7027 15 ABO ABO NNP cord-010119-t1x9gknd 7027 16 subgroups subgroup NNS cord-010119-t1x9gknd 7027 17 or or CC cord-010119-t1x9gknd 7027 18 physiologic physiologic JJ cord-010119-t1x9gknd 7027 19 conditions condition NNS cord-010119-t1x9gknd 7027 20 may may MD cord-010119-t1x9gknd 7027 21 lead lead VB cord-010119-t1x9gknd 7027 22 to to IN cord-010119-t1x9gknd 7027 23 mixed mixed JJ cord-010119-t1x9gknd 7027 24 - - HYPH cord-010119-t1x9gknd 7027 25 field field NN cord-010119-t1x9gknd 7027 26 agglutination agglutination NN cord-010119-t1x9gknd 7027 27 on on IN cord-010119-t1x9gknd 7027 28 ABO ABO NNP cord-010119-t1x9gknd 7027 29 typing type VBG cord-010119-t1x9gknd 7027 30 among among IN cord-010119-t1x9gknd 7027 31 blood blood NN cord-010119-t1x9gknd 7027 32 donors donor NNS cord-010119-t1x9gknd 7027 33 . . . cord-010119-t1x9gknd 7028 1 The the DT cord-010119-t1x9gknd 7028 2 B b NN cord-010119-t1x9gknd 7028 3 3 3 CD cord-010119-t1x9gknd 7028 4 phenotype phenotype NN cord-010119-t1x9gknd 7028 5 was be VBD cord-010119-t1x9gknd 7028 6 found find VBN cord-010119-t1x9gknd 7028 7 to to TO cord-010119-t1x9gknd 7028 8 be be VB cord-010119-t1x9gknd 7028 9 the the DT cord-010119-t1x9gknd 7028 10 most most RBS cord-010119-t1x9gknd 7028 11 common common JJ cord-010119-t1x9gknd 7028 12 subgroup subgroup NN cord-010119-t1x9gknd 7028 13 in in IN cord-010119-t1x9gknd 7028 14 Taiwanese Taiwanese NNP cord-010119-t1x9gknd 7028 15 . . . cord-010119-t1x9gknd 7029 1 However however RB cord-010119-t1x9gknd 7029 2 , , , cord-010119-t1x9gknd 7029 3 it -PRON- PRP cord-010119-t1x9gknd 7029 4 is be VBZ cord-010119-t1x9gknd 7029 5 hard hard JJ cord-010119-t1x9gknd 7029 6 to to TO cord-010119-t1x9gknd 7029 7 distinguish distinguish VB cord-010119-t1x9gknd 7029 8 the the DT cord-010119-t1x9gknd 7029 9 B b NN cord-010119-t1x9gknd 7029 10 3 3 CD cord-010119-t1x9gknd 7029 11 phenotype phenotype NN cord-010119-t1x9gknd 7029 12 from from IN cord-010119-t1x9gknd 7029 13 other other JJ cord-010119-t1x9gknd 7029 14 B b NN cord-010119-t1x9gknd 7029 15 subtypes subtype NNS cord-010119-t1x9gknd 7029 16 also also RB cord-010119-t1x9gknd 7029 17 with with IN cord-010119-t1x9gknd 7029 18 mixed mixed JJ cord-010119-t1x9gknd 7029 19 - - HYPH cord-010119-t1x9gknd 7029 20 field field NN cord-010119-t1x9gknd 7029 21 agglutination agglutination NN cord-010119-t1x9gknd 7029 22 using use VBG cord-010119-t1x9gknd 7029 23 routine routine JJ cord-010119-t1x9gknd 7029 24 serology serology NN cord-010119-t1x9gknd 7029 25 without without IN cord-010119-t1x9gknd 7029 26 the the DT cord-010119-t1x9gknd 7029 27 genotype genotype NN cord-010119-t1x9gknd 7029 28 . . . cord-010119-t1x9gknd 7030 1 This this DT cord-010119-t1x9gknd 7030 2 study study NN cord-010119-t1x9gknd 7030 3 aimed aim VBD cord-010119-t1x9gknd 7030 4 to to TO cord-010119-t1x9gknd 7030 5 evaluate evaluate VB cord-010119-t1x9gknd 7030 6 if if IN cord-010119-t1x9gknd 7030 7 flow flow NN cord-010119-t1x9gknd 7030 8 cytometric cytometric NN cord-010119-t1x9gknd 7030 9 method method NN cord-010119-t1x9gknd 7030 10 could could MD cord-010119-t1x9gknd 7030 11 alternatively alternatively RB cord-010119-t1x9gknd 7030 12 differentiate differentiate VB cord-010119-t1x9gknd 7030 13 different different JJ cord-010119-t1x9gknd 7030 14 B b NN cord-010119-t1x9gknd 7030 15 subtypes subtype NNS cord-010119-t1x9gknd 7030 16 with with IN cord-010119-t1x9gknd 7030 17 mixed mixed JJ cord-010119-t1x9gknd 7030 18 - - HYPH cord-010119-t1x9gknd 7030 19 field field NN cord-010119-t1x9gknd 7030 20 agglutination agglutination NN cord-010119-t1x9gknd 7030 21 rather rather RB cord-010119-t1x9gknd 7030 22 than than IN cord-010119-t1x9gknd 7030 23 using use VBG cord-010119-t1x9gknd 7030 24 molecular molecular JJ cord-010119-t1x9gknd 7030 25 genotyping genotyping NN cord-010119-t1x9gknd 7030 26 . . . cord-010119-t1x9gknd 7031 1 Study Study NNP cord-010119-t1x9gknd 7031 2 Design Design NNP cord-010119-t1x9gknd 7031 3 / / SYM cord-010119-t1x9gknd 7031 4 Method method NN cord-010119-t1x9gknd 7031 5 : : : cord-010119-t1x9gknd 7032 1 Blood blood NN cord-010119-t1x9gknd 7032 2 samples sample NNS cord-010119-t1x9gknd 7032 3 from from IN cord-010119-t1x9gknd 7032 4 30 30 CD cord-010119-t1x9gknd 7032 5 Taiwanese taiwanese JJ cord-010119-t1x9gknd 7032 6 blood blood NN cord-010119-t1x9gknd 7032 7 donors donor NNS cord-010119-t1x9gknd 7032 8 exhibiting exhibit VBG cord-010119-t1x9gknd 7032 9 known know VBN cord-010119-t1x9gknd 7032 10 common common JJ cord-010119-t1x9gknd 7032 11 ABO ABO NNP cord-010119-t1x9gknd 7032 12 phenotypes phenotype NNS cord-010119-t1x9gknd 7032 13 were be VBD cord-010119-t1x9gknd 7032 14 included include VBN cord-010119-t1x9gknd 7032 15 to to TO cord-010119-t1x9gknd 7032 16 establish establish VB cord-010119-t1x9gknd 7032 17 normal normal JJ cord-010119-t1x9gknd 7032 18 flow flow NN cord-010119-t1x9gknd 7032 19 cytometric cytometric NN cord-010119-t1x9gknd 7032 20 patterns pattern NNS cord-010119-t1x9gknd 7032 21 and and CC cord-010119-t1x9gknd 7032 22 genotyped genotype VBN cord-010119-t1x9gknd 7032 23 . . . cord-010119-t1x9gknd 7033 1 Blood blood NN cord-010119-t1x9gknd 7033 2 samples sample NNS cord-010119-t1x9gknd 7033 3 ( ( -LRB- cord-010119-t1x9gknd 7033 4 n552 n552 JJ cord-010119-t1x9gknd 7033 5 ) ) -RRB- cord-010119-t1x9gknd 7033 6 from from IN cord-010119-t1x9gknd 7033 7 B B NNP cord-010119-t1x9gknd 7033 8 subtype subtype NN cord-010119-t1x9gknd 7033 9 donors donor NNS cord-010119-t1x9gknd 7033 10 with with IN cord-010119-t1x9gknd 7033 11 mixed mixed JJ cord-010119-t1x9gknd 7033 12 - - HYPH cord-010119-t1x9gknd 7033 13 field field NN cord-010119-t1x9gknd 7033 14 agglutination agglutination NN cord-010119-t1x9gknd 7033 15 by by IN cord-010119-t1x9gknd 7033 16 routine routine JJ cord-010119-t1x9gknd 7033 17 serology serology NN cord-010119-t1x9gknd 7033 18 ( ( -LRB- cord-010119-t1x9gknd 7033 19 tube tube NN cord-010119-t1x9gknd 7033 20 method method NN cord-010119-t1x9gknd 7033 21 and and CC cord-010119-t1x9gknd 7033 22 gel gel NN cord-010119-t1x9gknd 7033 23 card card NN cord-010119-t1x9gknd 7033 24 ) ) -RRB- cord-010119-t1x9gknd 7033 25 were be VBD cord-010119-t1x9gknd 7033 26 further further RB cord-010119-t1x9gknd 7033 27 analyzed analyze VBN cord-010119-t1x9gknd 7033 28 by by IN cord-010119-t1x9gknd 7033 29 flow flow NN cord-010119-t1x9gknd 7033 30 cytometry cytometry NN cord-010119-t1x9gknd 7033 31 and and CC cord-010119-t1x9gknd 7033 32 genotyping genotyping NN cord-010119-t1x9gknd 7033 33 . . . cord-010119-t1x9gknd 7034 1 Flow flow VB cord-010119-t1x9gknd 7034 2 cytometric cytometric NN cord-010119-t1x9gknd 7034 3 method method NN cord-010119-t1x9gknd 7034 4 was be VBD cord-010119-t1x9gknd 7034 5 performed perform VBN cord-010119-t1x9gknd 7034 6 by by IN cord-010119-t1x9gknd 7034 7 FACSCalibur facscalibur NN cord-010119-t1x9gknd 7034 8 flow flow NN cord-010119-t1x9gknd 7034 9 cytometry cytometry NN cord-010119-t1x9gknd 7034 10 using use VBG cord-010119-t1x9gknd 7034 11 the the DT cord-010119-t1x9gknd 7034 12 Gamma Gamma NNP cord-010119-t1x9gknd 7034 13 - - HYPH cord-010119-t1x9gknd 7034 14 clone clone NN cord-010119-t1x9gknd 7034 15 anti anti JJ cord-010119-t1x9gknd 7034 16 - - NN cord-010119-t1x9gknd 7034 17 A a NN cord-010119-t1x9gknd 7035 1 and and CC cord-010119-t1x9gknd 7036 1 -B. -B. VBN cord-010119-t1x9gknd 7036 2 For for IN cord-010119-t1x9gknd 7036 3 genotyping genotyping NN cord-010119-t1x9gknd 7036 4 , , , cord-010119-t1x9gknd 7036 5 exon exon NN cord-010119-t1x9gknd 7036 6 6 6 CD cord-010119-t1x9gknd 7036 7 and and CC cord-010119-t1x9gknd 7036 8 exon exon NN cord-010119-t1x9gknd 7036 9 7 7 CD cord-010119-t1x9gknd 7036 10 of of IN cord-010119-t1x9gknd 7036 11 the the DT cord-010119-t1x9gknd 7036 12 ABO ABO NNP cord-010119-t1x9gknd 7036 13 gene gene NN cord-010119-t1x9gknd 7036 14 were be VBD cord-010119-t1x9gknd 7036 15 amplified amplify VBN cord-010119-t1x9gknd 7036 16 and and CC cord-010119-t1x9gknd 7036 17 sequenced sequence VBN cord-010119-t1x9gknd 7036 18 . . . cord-010119-t1x9gknd 7037 1 The the DT cord-010119-t1x9gknd 7037 2 ABO*B3.03 abo*b3.03 CD cord-010119-t1x9gknd 7037 3 allele allele NN cord-010119-t1x9gknd 7037 4 was be VBD cord-010119-t1x9gknd 7037 5 confirmed confirm VBN cord-010119-t1x9gknd 7037 6 by by IN cord-010119-t1x9gknd 7037 7 PCR PCR NNP cord-010119-t1x9gknd 7037 8 - - HYPH cord-010119-t1x9gknd 7037 9 RFLP RFLP NNP cord-010119-t1x9gknd 7037 10 analysis analysis NN cord-010119-t1x9gknd 7037 11 . . . cord-010119-t1x9gknd 7038 1 Results result NNS cord-010119-t1x9gknd 7038 2 / / SYM cord-010119-t1x9gknd 7038 3 Finding finding NN cord-010119-t1x9gknd 7038 4 : : : cord-010119-t1x9gknd 7039 1 Among among IN cord-010119-t1x9gknd 7039 2 52 52 CD cord-010119-t1x9gknd 7039 3 subjects subject NNS cord-010119-t1x9gknd 7039 4 with with IN cord-010119-t1x9gknd 7039 5 B b NN cord-010119-t1x9gknd 7039 6 3 3 CD cord-010119-t1x9gknd 7039 7 or or CC cord-010119-t1x9gknd 7039 8 AB AB NNP cord-010119-t1x9gknd 7039 9 3 3 CD cord-010119-t1x9gknd 7039 10 phenotypes phenotype NNS cord-010119-t1x9gknd 7039 11 , , , cord-010119-t1x9gknd 7039 12 47 47 CD cord-010119-t1x9gknd 7039 13 were be VBD cord-010119-t1x9gknd 7039 14 genotyped genotype VBN cord-010119-t1x9gknd 7039 15 as as IN cord-010119-t1x9gknd 7039 16 ABO*B3.03 abo*b3.03 CD cord-010119-t1x9gknd 7039 17 . . . cord-010119-t1x9gknd 7040 1 The the DT cord-010119-t1x9gknd 7040 2 ABO*B3.03 abo*b3.03 CD cord-010119-t1x9gknd 7040 3 group group NN cord-010119-t1x9gknd 7040 4 performed perform VBD cord-010119-t1x9gknd 7040 5 similar similar JJ cord-010119-t1x9gknd 7040 6 characteristic characteristic JJ cord-010119-t1x9gknd 7040 7 flow flow NN cord-010119-t1x9gknd 7040 8 cytometric cytometric NN cord-010119-t1x9gknd 7040 9 pattern pattern NN cord-010119-t1x9gknd 7040 10 and and CC cord-010119-t1x9gknd 7040 11 the the DT cord-010119-t1x9gknd 7040 12 profile profile NN cord-010119-t1x9gknd 7040 13 was be VBD cord-010119-t1x9gknd 7040 14 reproducible reproducible JJ cord-010119-t1x9gknd 7040 15 over over IN cord-010119-t1x9gknd 7040 16 time time NN cord-010119-t1x9gknd 7040 17 . . . cord-010119-t1x9gknd 7041 1 The the DT cord-010119-t1x9gknd 7041 2 pattern pattern NN cord-010119-t1x9gknd 7041 3 showed show VBD cord-010119-t1x9gknd 7041 4 the the DT cord-010119-t1x9gknd 7041 5 main main JJ cord-010119-t1x9gknd 7041 6 population population NN cord-010119-t1x9gknd 7041 7 of of IN cord-010119-t1x9gknd 7041 8 cells cell NNS cord-010119-t1x9gknd 7041 9 expressed express VBD cord-010119-t1x9gknd 7041 10 no no DT cord-010119-t1x9gknd 7041 11 B b NN cord-010119-t1x9gknd 7041 12 antigen antigen NN cord-010119-t1x9gknd 7041 13 , , , cord-010119-t1x9gknd 7041 14 while while IN cord-010119-t1x9gknd 7041 15 a a DT cord-010119-t1x9gknd 7041 16 percentage percentage NN cord-010119-t1x9gknd 7041 17 ( ( -LRB- cord-010119-t1x9gknd 7041 18 37.81 37.81 CD cord-010119-t1x9gknd 7041 19 6 6 CD cord-010119-t1x9gknd 7041 20 6.62 6.62 CD cord-010119-t1x9gknd 7041 21 ) ) -RRB- cord-010119-t1x9gknd 7041 22 of of IN cord-010119-t1x9gknd 7041 23 the the DT cord-010119-t1x9gknd 7041 24 RBCs rbc NNS cord-010119-t1x9gknd 7041 25 exhibited exhibit VBD cord-010119-t1x9gknd 7041 26 B b NN cord-010119-t1x9gknd 7041 27 antigen antigen NN cord-010119-t1x9gknd 7041 28 levels level NNS cord-010119-t1x9gknd 7041 29 diminishing diminish VBG cord-010119-t1x9gknd 7041 30 with with IN cord-010119-t1x9gknd 7041 31 increasing increase VBG cord-010119-t1x9gknd 7041 32 of of IN cord-010119-t1x9gknd 7041 33 fluorescence fluorescence NN cord-010119-t1x9gknd 7041 34 . . . cord-010119-t1x9gknd 7042 1 Other other JJ cord-010119-t1x9gknd 7042 2 5 5 CD cord-010119-t1x9gknd 7042 3 subjects subject NNS cord-010119-t1x9gknd 7042 4 with with IN cord-010119-t1x9gknd 7042 5 B b NN cord-010119-t1x9gknd 7042 6 3 3 CD cord-010119-t1x9gknd 7042 7 or or CC cord-010119-t1x9gknd 7042 8 AB AB NNP cord-010119-t1x9gknd 7042 9 3 3 CD cord-010119-t1x9gknd 7042 10 subjects subject NNS cord-010119-t1x9gknd 7042 11 , , , cord-010119-t1x9gknd 7042 12 genotyped genotype VBN cord-010119-t1x9gknd 7042 13 as as IN cord-010119-t1x9gknd 7042 14 ABO*B3.06(n51 ABO*B3.06(n51 NNP cord-010119-t1x9gknd 7042 15 ) ) -RRB- cord-010119-t1x9gknd 7042 16 , , , cord-010119-t1x9gknd 7042 17 ABO*BW.03(n51 ABO*BW.03(n51 NNP cord-010119-t1x9gknd 7042 18 ) ) -RRB- cord-010119-t1x9gknd 7042 19 , , , cord-010119-t1x9gknd 7042 20 ABO*BW.11(n51 ABO*BW.11(n51 NNP cord-010119-t1x9gknd 7042 21 ) ) -RRB- cord-010119-t1x9gknd 7042 22 , , , cord-010119-t1x9gknd 7042 23 ABO*BW.12(n51 ABO*BW.12(n51 NNP cord-010119-t1x9gknd 7042 24 ) ) -RRB- cord-010119-t1x9gknd 7043 1 and and CC cord-010119-t1x9gknd 7043 2 ABO*BW.29(n51 ABO*BW.29(n51 NNP cord-010119-t1x9gknd 7043 3 ) ) -RRB- cord-010119-t1x9gknd 7043 4 , , , cord-010119-t1x9gknd 7043 5 displayed display VBD cord-010119-t1x9gknd 7043 6 flow flow NN cord-010119-t1x9gknd 7043 7 patterns pattern NNS cord-010119-t1x9gknd 7043 8 differed differ VBD cord-010119-t1x9gknd 7043 9 from from IN cord-010119-t1x9gknd 7043 10 the the DT cord-010119-t1x9gknd 7043 11 ABO*B3.03 abo*b3.03 CD cord-010119-t1x9gknd 7043 12 group group NN cord-010119-t1x9gknd 7043 13 . . . cord-010119-t1x9gknd 7044 1 The the DT cord-010119-t1x9gknd 7044 2 ABO*BW.03 ABO*BW.03 NNP cord-010119-t1x9gknd 7044 3 , , , cord-010119-t1x9gknd 7044 4 ABO*BW.11 ABO*BW.11 NNP cord-010119-t1x9gknd 7044 5 and and CC cord-010119-t1x9gknd 7044 6 ABO*B3.06 abo*b3.06 JJ cord-010119-t1x9gknd 7044 7 subjects subject NNS cord-010119-t1x9gknd 7044 8 also also RB cord-010119-t1x9gknd 7044 9 showed show VBD cord-010119-t1x9gknd 7044 10 a a DT cord-010119-t1x9gknd 7044 11 main main JJ cord-010119-t1x9gknd 7044 12 population population NN cord-010119-t1x9gknd 7044 13 of of IN cord-010119-t1x9gknd 7044 14 cells cell NNS cord-010119-t1x9gknd 7044 15 expressed express VBD cord-010119-t1x9gknd 7044 16 no no DT cord-010119-t1x9gknd 7044 17 B b NN cord-010119-t1x9gknd 7044 18 antigen antigen NN cord-010119-t1x9gknd 7044 19 and and CC cord-010119-t1x9gknd 7044 20 , , , cord-010119-t1x9gknd 7044 21 however however RB cord-010119-t1x9gknd 7044 22 , , , cord-010119-t1x9gknd 7044 23 less less JJR cord-010119-t1x9gknd 7044 24 percentage percentage NN cord-010119-t1x9gknd 7044 25 of of IN cord-010119-t1x9gknd 7044 26 RBCs rbc NNS cord-010119-t1x9gknd 7044 27 exhibited exhibit VBD cord-010119-t1x9gknd 7044 28 B b NN cord-010119-t1x9gknd 7044 29 antigen antigen NN cord-010119-t1x9gknd 7044 30 levels level NNS cord-010119-t1x9gknd 7044 31 ( ( -LRB- cord-010119-t1x9gknd 7044 32 < < NNP cord-010119-t1x9gknd 7044 33 10 10 CD cord-010119-t1x9gknd 7044 34 % % NN cord-010119-t1x9gknd 7044 35 in in IN cord-010119-t1x9gknd 7044 36 ABO*BW.03 ABO*BW.03 NNP cord-010119-t1x9gknd 7044 37 and and CC cord-010119-t1x9gknd 7044 38 ABO*BW.11 abo*bw.11 JJ cord-010119-t1x9gknd 7044 39 subjects subject NNS cord-010119-t1x9gknd 7044 40 and and CC cord-010119-t1x9gknd 7044 41 < < XX cord-010119-t1x9gknd 7044 42 20 20 CD cord-010119-t1x9gknd 7044 43 % % NN cord-010119-t1x9gknd 7044 44 in in IN cord-010119-t1x9gknd 7044 45 ABO*B3.06 ABO*B3.06 NNP cord-010119-t1x9gknd 7044 46 subject subject NN cord-010119-t1x9gknd 7044 47 ) ) -RRB- cord-010119-t1x9gknd 7044 48 . . . cord-010119-t1x9gknd 7045 1 Both both CC cord-010119-t1x9gknd 7045 2 ABO*BW.12 ABO*BW.12 NNP cord-010119-t1x9gknd 7045 3 and and CC cord-010119-t1x9gknd 7045 4 ABO*BW.29 ABO*BW.29 NNP cord-010119-t1x9gknd 7045 5 displayed display VBD cord-010119-t1x9gknd 7045 6 a a DT cord-010119-t1x9gknd 7045 7 wedge wedge NN cord-010119-t1x9gknd 7045 8 - - HYPH cord-010119-t1x9gknd 7045 9 shaped shape VBN cord-010119-t1x9gknd 7045 10 pattern pattern NN cord-010119-t1x9gknd 7045 11 . . . cord-010119-t1x9gknd 7046 1 Conclusion conclusion NN cord-010119-t1x9gknd 7046 2 : : : cord-010119-t1x9gknd 7047 1 The the DT cord-010119-t1x9gknd 7047 2 flow flow NN cord-010119-t1x9gknd 7047 3 cytometric cytometric NN cord-010119-t1x9gknd 7047 4 method method NN cord-010119-t1x9gknd 7047 5 for for IN cord-010119-t1x9gknd 7047 6 the the DT cord-010119-t1x9gknd 7047 7 detection detection NN cord-010119-t1x9gknd 7047 8 of of IN cord-010119-t1x9gknd 7047 9 B b NN cord-010119-t1x9gknd 7047 10 antigens antigen NNS cord-010119-t1x9gknd 7047 11 on on IN cord-010119-t1x9gknd 7047 12 RBC RBC NNP cord-010119-t1x9gknd 7047 13 might may MD cord-010119-t1x9gknd 7047 14 be be VB cord-010119-t1x9gknd 7047 15 useful useful JJ cord-010119-t1x9gknd 7047 16 in in IN cord-010119-t1x9gknd 7047 17 discriminating discriminate VBG cord-010119-t1x9gknd 7047 18 between between IN cord-010119-t1x9gknd 7047 19 B b NN cord-010119-t1x9gknd 7047 20 subtypes subtype NNS cord-010119-t1x9gknd 7047 21 with with IN cord-010119-t1x9gknd 7047 22 mixed mixed JJ cord-010119-t1x9gknd 7047 23 - - HYPH cord-010119-t1x9gknd 7047 24 field field NN cord-010119-t1x9gknd 7047 25 agglutination agglutination NN cord-010119-t1x9gknd 7047 26 , , , cord-010119-t1x9gknd 7047 27 especially especially RB cord-010119-t1x9gknd 7047 28 ABO*B3.03 abo*b3.03 CD cord-010119-t1x9gknd 7047 29 genotype genotype NN cord-010119-t1x9gknd 7047 30 . . . cord-010119-t1x9gknd 7048 1 This this DT cord-010119-t1x9gknd 7048 2 approach approach NN cord-010119-t1x9gknd 7048 3 could could MD cord-010119-t1x9gknd 7048 4 assist assist VB cord-010119-t1x9gknd 7048 5 the the DT cord-010119-t1x9gknd 7048 6 serological serological JJ cord-010119-t1x9gknd 7048 7 ABO ABO NNP cord-010119-t1x9gknd 7048 8 subgrouping subgroupe VBG cord-010119-t1x9gknd 7048 9 in in IN cord-010119-t1x9gknd 7048 10 clinical clinical JJ cord-010119-t1x9gknd 7048 11 reference reference NN cord-010119-t1x9gknd 7048 12 laboratory laboratory NN cord-010119-t1x9gknd 7048 13 . . . cord-010119-t1x9gknd 7049 1 Frequencies frequency NNS cord-010119-t1x9gknd 7049 2 and and CC cord-010119-t1x9gknd 7049 3 Specificities Specificities NNPS cord-010119-t1x9gknd 7049 4 of of IN cord-010119-t1x9gknd 7049 5 " " `` cord-010119-t1x9gknd 7049 6 Solid Solid NNP cord-010119-t1x9gknd 7049 7 - - HYPH cord-010119-t1x9gknd 7049 8 Phase phase NN cord-010119-t1x9gknd 7049 9 Only only RB cord-010119-t1x9gknd 7049 10 " " '' cord-010119-t1x9gknd 7049 11 Detected detect VBD cord-010119-t1x9gknd 7049 12 Erythrocyte Erythrocyte NNP cord-010119-t1x9gknd 7049 13 Antibodies Antibodies NNPS cord-010119-t1x9gknd 7049 14 : : : cord-010119-t1x9gknd 7049 15 Is be VBZ cord-010119-t1x9gknd 7049 16 Solid solid JJ cord-010119-t1x9gknd 7049 17 Phase Phase NNP cord-010119-t1x9gknd 7050 1 Testing test VBG cord-010119-t1x9gknd 7050 2 Worth Worth NNP cord-010119-t1x9gknd 7050 3 the the DT cord-010119-t1x9gknd 7050 4 Headache headache NN cord-010119-t1x9gknd 7050 5 ? ? . cord-010119-t1x9gknd 7051 1 Karen Karen NNP cord-010119-t1x9gknd 7051 2 Finegan Finegan NNP cord-010119-t1x9gknd 7051 3 * * NFP cord-010119-t1x9gknd 7051 4 , , , cord-010119-t1x9gknd 7051 5 Karen Karen NNP cord-010119-t1x9gknd 7051 6 Gray Gray NNP cord-010119-t1x9gknd 7051 7 , , , cord-010119-t1x9gknd 7051 8 Jill Jill NNP cord-010119-t1x9gknd 7051 9 Adamski Adamski NNP cord-010119-t1x9gknd 7051 10 , , , cord-010119-t1x9gknd 7051 11 Theresa Theresa NNP cord-010119-t1x9gknd 7051 12 Kinard Kinard NNP cord-010119-t1x9gknd 7051 13 and and CC cord-010119-t1x9gknd 7051 14 Qun Qun NNP cord-010119-t1x9gknd 7051 15 Lu Lu NNP cord-010119-t1x9gknd 7051 16 . . . cord-010119-t1x9gknd 7052 1 Background Background NNP cord-010119-t1x9gknd 7052 2 / / SYM cord-010119-t1x9gknd 7052 3 Case Case NNP cord-010119-t1x9gknd 7052 4 Studies Studies NNPS cord-010119-t1x9gknd 7052 5 : : : cord-010119-t1x9gknd 7053 1 An an DT cord-010119-t1x9gknd 7053 2 effort effort NN cord-010119-t1x9gknd 7053 3 to to TO cord-010119-t1x9gknd 7053 4 re re VB cord-010119-t1x9gknd 7053 5 - - VB cord-010119-t1x9gknd 7053 6 evaluate evaluate VB cord-010119-t1x9gknd 7053 7 automated automate VBN cord-010119-t1x9gknd 7053 8 testing testing NN cord-010119-t1x9gknd 7053 9 platforms platform NNS cord-010119-t1x9gknd 7053 10 ( ( -LRB- cord-010119-t1x9gknd 7053 11 automated automate VBN cord-010119-t1x9gknd 7053 12 solid solid JJ cord-010119-t1x9gknd 7053 13 - - HYPH cord-010119-t1x9gknd 7053 14 phase phase NN cord-010119-t1x9gknd 7053 15 red red JJ cord-010119-t1x9gknd 7053 16 blood blood NN cord-010119-t1x9gknd 7053 17 cell cell NN cord-010119-t1x9gknd 7053 18 adherence adherence NN cord-010119-t1x9gknd 7053 19 vs vs IN cord-010119-t1x9gknd 7053 20 automated automate VBN cord-010119-t1x9gknd 7053 21 Gel gel NN cord-010119-t1x9gknd 7053 22 column column NN cord-010119-t1x9gknd 7053 23 agglutination agglutination NN cord-010119-t1x9gknd 7053 24 ) ) -RRB- cord-010119-t1x9gknd 7053 25 was be VBD cord-010119-t1x9gknd 7053 26 recently recently RB cord-010119-t1x9gknd 7053 27 initiated initiate VBN cord-010119-t1x9gknd 7053 28 due due IN cord-010119-t1x9gknd 7053 29 to to IN cord-010119-t1x9gknd 7053 30 the the DT cord-010119-t1x9gknd 7053 31 perception perception NN cord-010119-t1x9gknd 7053 32 of of IN cord-010119-t1x9gknd 7053 33 excessive excessive JJ cord-010119-t1x9gknd 7053 34 equivocal equivocal JJ cord-010119-t1x9gknd 7053 35 reactions reaction NNS cord-010119-t1x9gknd 7053 36 from from IN cord-010119-t1x9gknd 7053 37 the the DT cord-010119-t1x9gknd 7053 38 solid solid JJ cord-010119-t1x9gknd 7053 39 - - HYPH cord-010119-t1x9gknd 7053 40 phase phase NN cord-010119-t1x9gknd 7053 41 resulting resulting NN cord-010119-t1x9gknd 7053 42 in in IN cord-010119-t1x9gknd 7053 43 " " `` cord-010119-t1x9gknd 7053 44 unnecessary unnecessary JJ cord-010119-t1x9gknd 7053 45 " " '' cord-010119-t1x9gknd 7053 46 workup workup JJ cord-010119-t1x9gknd 7053 47 at at IN cord-010119-t1x9gknd 7053 48 one one CD cord-010119-t1x9gknd 7053 49 site site NN cord-010119-t1x9gknd 7053 50 of of IN cord-010119-t1x9gknd 7053 51 a a DT cord-010119-t1x9gknd 7053 52 hospital hospital NN cord-010119-t1x9gknd 7053 53 system system NN cord-010119-t1x9gknd 7053 54 . . . cord-010119-t1x9gknd 7054 1 The the DT cord-010119-t1x9gknd 7054 2 data datum NNS cord-010119-t1x9gknd 7054 3 available available JJ cord-010119-t1x9gknd 7054 4 from from IN cord-010119-t1x9gknd 7054 5 parallel parallel JJ cord-010119-t1x9gknd 7054 6 testing testing NN cord-010119-t1x9gknd 7054 7 on on IN cord-010119-t1x9gknd 7054 8 solid solid JJ cord-010119-t1x9gknd 7054 9 - - HYPH cord-010119-t1x9gknd 7054 10 phase phase NN cord-010119-t1x9gknd 7054 11 , , , cord-010119-t1x9gknd 7054 12 Gel gel NN cord-010119-t1x9gknd 7054 13 , , , cord-010119-t1x9gknd 7054 14 and and CC cord-010119-t1x9gknd 7054 15 PEG PEG NNP cord-010119-t1x9gknd 7054 16 performed perform VBD cord-010119-t1x9gknd 7054 17 at at IN cord-010119-t1x9gknd 7054 18 another another DT cord-010119-t1x9gknd 7054 19 cite cite NN cord-010119-t1x9gknd 7054 20 of of IN cord-010119-t1x9gknd 7054 21 the the DT cord-010119-t1x9gknd 7054 22 same same JJ cord-010119-t1x9gknd 7054 23 hospital hospital NN cord-010119-t1x9gknd 7054 24 system system NN cord-010119-t1x9gknd 7054 25 was be VBD cord-010119-t1x9gknd 7054 26 collected collect VBN cord-010119-t1x9gknd 7054 27 and and CC cord-010119-t1x9gknd 7054 28 evaluated evaluate VBN cord-010119-t1x9gknd 7054 29 to to TO cord-010119-t1x9gknd 7054 30 determine determine VB cord-010119-t1x9gknd 7054 31 the the DT cord-010119-t1x9gknd 7054 32 frequencies frequency NNS cord-010119-t1x9gknd 7054 33 and and CC cord-010119-t1x9gknd 7054 34 specificities specificity NNS cord-010119-t1x9gknd 7054 35 of of IN cord-010119-t1x9gknd 7054 36 " " `` cord-010119-t1x9gknd 7054 37 solid solid JJ cord-010119-t1x9gknd 7054 38 - - HYPH cord-010119-t1x9gknd 7054 39 phase phase NN cord-010119-t1x9gknd 7054 40 only only RB cord-010119-t1x9gknd 7054 41 " " `` cord-010119-t1x9gknd 7054 42 detected detect VBN cord-010119-t1x9gknd 7054 43 erythrocyte erythrocyte NN cord-010119-t1x9gknd 7054 44 antibodies antibody NNS cord-010119-t1x9gknd 7054 45 and and CC cord-010119-t1x9gknd 7054 46 to to TO cord-010119-t1x9gknd 7054 47 see see VB cord-010119-t1x9gknd 7054 48 if if IN cord-010119-t1x9gknd 7054 49 solid solid JJ cord-010119-t1x9gknd 7054 50 - - HYPH cord-010119-t1x9gknd 7054 51 phase phase NN cord-010119-t1x9gknd 7054 52 only only RB cord-010119-t1x9gknd 7054 53 antibody antibody NN cord-010119-t1x9gknd 7054 54 workup workup NN cord-010119-t1x9gknd 7054 55 is be VBZ cord-010119-t1x9gknd 7054 56 necessary necessary JJ cord-010119-t1x9gknd 7054 57 for for IN cord-010119-t1x9gknd 7054 58 patient patient JJ cord-010119-t1x9gknd 7054 59 care care NN cord-010119-t1x9gknd 7054 60 . . . cord-010119-t1x9gknd 7055 1 Study Study NNP cord-010119-t1x9gknd 7055 2 Design Design NNP cord-010119-t1x9gknd 7055 3 / / SYM cord-010119-t1x9gknd 7055 4 Methods method NNS cord-010119-t1x9gknd 7055 5 : : : cord-010119-t1x9gknd 7056 1 Throughout throughout IN cord-010119-t1x9gknd 7056 2 2016 2016 CD cord-010119-t1x9gknd 7056 3 , , , cord-010119-t1x9gknd 7056 4 the the DT cord-010119-t1x9gknd 7056 5 transfusion transfusion NN cord-010119-t1x9gknd 7056 6 service service NN cord-010119-t1x9gknd 7056 7 used use VBD cord-010119-t1x9gknd 7056 8 automated automate VBN cord-010119-t1x9gknd 7056 9 solid solid JJ cord-010119-t1x9gknd 7056 10 - - HYPH cord-010119-t1x9gknd 7056 11 phase phase NN cord-010119-t1x9gknd 7056 12 red red JJ cord-010119-t1x9gknd 7056 13 blood blood NN cord-010119-t1x9gknd 7056 14 cell cell NN cord-010119-t1x9gknd 7056 15 ( ( -LRB- cord-010119-t1x9gknd 7056 16 RBC RBC NNP cord-010119-t1x9gknd 7056 17 ) ) -RRB- cord-010119-t1x9gknd 7056 18 adherence adherence NN cord-010119-t1x9gknd 7056 19 as as IN cord-010119-t1x9gknd 7056 20 the the DT cord-010119-t1x9gknd 7056 21 primary primary JJ cord-010119-t1x9gknd 7056 22 method method NN cord-010119-t1x9gknd 7056 23 for for IN cord-010119-t1x9gknd 7056 24 antibody antibody NN cord-010119-t1x9gknd 7056 25 screening screening NN cord-010119-t1x9gknd 7056 26 and and CC cord-010119-t1x9gknd 7056 27 identification identification NN cord-010119-t1x9gknd 7056 28 . . . cord-010119-t1x9gknd 7057 1 All all DT cord-010119-t1x9gknd 7057 2 solid solid JJ cord-010119-t1x9gknd 7057 3 - - HYPH cord-010119-t1x9gknd 7057 4 phase phase NN cord-010119-t1x9gknd 7057 5 antibody antibody NN cord-010119-t1x9gknd 7057 6 screen screen NN cord-010119-t1x9gknd 7057 7 positive positive JJ cord-010119-t1x9gknd 7057 8 samples sample NNS cord-010119-t1x9gknd 7057 9 were be VBD cord-010119-t1x9gknd 7057 10 re re VBN cord-010119-t1x9gknd 7057 11 - - VBN cord-010119-t1x9gknd 7057 12 tested test VBN cord-010119-t1x9gknd 7057 13 using use VBG cord-010119-t1x9gknd 7057 14 both both DT cord-010119-t1x9gknd 7057 15 Gel Gel NNP cord-010119-t1x9gknd 7057 16 column column NN cord-010119-t1x9gknd 7057 17 agglutination agglutination NN cord-010119-t1x9gknd 7057 18 and and CC cord-010119-t1x9gknd 7057 19 PEG peg NN cord-010119-t1x9gknd 7057 20 method method NN cord-010119-t1x9gknd 7057 21 manually manually RB cord-010119-t1x9gknd 7057 22 in in IN cord-010119-t1x9gknd 7057 23 order order NN cord-010119-t1x9gknd 7057 24 to to TO cord-010119-t1x9gknd 7057 25 determine determine VB cord-010119-t1x9gknd 7057 26 which which WDT cord-010119-t1x9gknd 7057 27 method method NN cord-010119-t1x9gknd 7057 28 should should MD cord-010119-t1x9gknd 7057 29 be be VB cord-010119-t1x9gknd 7057 30 used use VBN cord-010119-t1x9gknd 7057 31 for for IN cord-010119-t1x9gknd 7057 32 antiglobulin antiglobulin NNP cord-010119-t1x9gknd 7057 33 phase phase NNP cord-010119-t1x9gknd 7057 34 crossmatch crossmatch NN cord-010119-t1x9gknd 7057 35 of of IN cord-010119-t1x9gknd 7057 36 RBC RBC NNP cord-010119-t1x9gknd 7057 37 products product NNS cord-010119-t1x9gknd 7057 38 . . . cord-010119-t1x9gknd 7058 1 All all DT cord-010119-t1x9gknd 7058 2 antibody antibody NN cord-010119-t1x9gknd 7058 3 screen screen NN cord-010119-t1x9gknd 7058 4 results result NNS cord-010119-t1x9gknd 7058 5 on on IN cord-010119-t1x9gknd 7058 6 three three CD cord-010119-t1x9gknd 7058 7 methods method NNS cord-010119-t1x9gknd 7058 8 and and CC cord-010119-t1x9gknd 7058 9 final final JJ cord-010119-t1x9gknd 7058 10 antibody antibody NN cord-010119-t1x9gknd 7058 11 identification identification NN cord-010119-t1x9gknd 7058 12 results result NNS cord-010119-t1x9gknd 7058 13 were be VBD cord-010119-t1x9gknd 7058 14 transcribed transcribe VBN cord-010119-t1x9gknd 7058 15 into into IN cord-010119-t1x9gknd 7058 16 a a DT cord-010119-t1x9gknd 7058 17 spread spread NN cord-010119-t1x9gknd 7058 18 sheet sheet NN cord-010119-t1x9gknd 7058 19 and and CC cord-010119-t1x9gknd 7058 20 analyzed analyze VBD cord-010119-t1x9gknd 7058 21 . . . cord-010119-t1x9gknd 7059 1 Results result NNS cord-010119-t1x9gknd 7059 2 / / SYM cord-010119-t1x9gknd 7059 3 Findings finding NNS cord-010119-t1x9gknd 7059 4 : : : cord-010119-t1x9gknd 7060 1 A a DT cord-010119-t1x9gknd 7060 2 total total NN cord-010119-t1x9gknd 7060 3 of of IN cord-010119-t1x9gknd 7060 4 398 398 CD cord-010119-t1x9gknd 7060 5 patients patient NNS cord-010119-t1x9gknd 7060 6 were be VBD cord-010119-t1x9gknd 7060 7 positive positive JJ cord-010119-t1x9gknd 7060 8 on on IN cord-010119-t1x9gknd 7060 9 solid solid JJ cord-010119-t1x9gknd 7060 10 - - HYPH cord-010119-t1x9gknd 7060 11 phase phase NN cord-010119-t1x9gknd 7060 12 antibody antibody NN cord-010119-t1x9gknd 7060 13 screen screen NN cord-010119-t1x9gknd 7060 14 and and CC cord-010119-t1x9gknd 7060 15 re re NNS cord-010119-t1x9gknd 7060 16 - - VBN cord-010119-t1x9gknd 7060 17 tested test VBN cord-010119-t1x9gknd 7060 18 on on IN cord-010119-t1x9gknd 7060 19 Gel Gel NNP cord-010119-t1x9gknd 7060 20 and and CC cord-010119-t1x9gknd 7060 21 PEG PEG NNP cord-010119-t1x9gknd 7060 22 antibody antibody NN cord-010119-t1x9gknd 7060 23 screen screen NN cord-010119-t1x9gknd 7060 24 . . . cord-010119-t1x9gknd 7061 1 In in IN cord-010119-t1x9gknd 7061 2 12 12 CD cord-010119-t1x9gknd 7061 3 % % NN cord-010119-t1x9gknd 7061 4 ( ( -LRB- cord-010119-t1x9gknd 7061 5 n549 n549 NNP cord-010119-t1x9gknd 7061 6 ) ) -RRB- cord-010119-t1x9gknd 7061 7 patients patient VBZ cord-010119-t1x9gknd 7061 8 antibody antibody NN cord-010119-t1x9gknd 7061 9 reactivity reactivity NN cord-010119-t1x9gknd 7061 10 observed observe VBN cord-010119-t1x9gknd 7061 11 in in IN cord-010119-t1x9gknd 7061 12 solid solid JJ cord-010119-t1x9gknd 7061 13 phase phase NN cord-010119-t1x9gknd 7061 14 only only RB cord-010119-t1x9gknd 7061 15 and and CC cord-010119-t1x9gknd 7061 16 the the DT cord-010119-t1x9gknd 7061 17 concurrent concurrent JJ cord-010119-t1x9gknd 7061 18 Gel gel NN cord-010119-t1x9gknd 7061 19 and and CC cord-010119-t1x9gknd 7061 20 PEG PEG NNP cord-010119-t1x9gknd 7061 21 testing testing NN cord-010119-t1x9gknd 7061 22 were be VBD cord-010119-t1x9gknd 7061 23 completely completely RB cord-010119-t1x9gknd 7061 24 negative negative JJ cord-010119-t1x9gknd 7061 25 . . . cord-010119-t1x9gknd 7062 1 Of of IN cord-010119-t1x9gknd 7062 2 them -PRON- PRP cord-010119-t1x9gknd 7062 3 clinically clinically RB cord-010119-t1x9gknd 7062 4 significant significant JJ cord-010119-t1x9gknd 7062 5 RBC RBC NNP cord-010119-t1x9gknd 7062 6 alloantibodies alloantibody NNS cord-010119-t1x9gknd 7062 7 , , , cord-010119-t1x9gknd 7062 8 warm warm JJ cord-010119-t1x9gknd 7062 9 autoantibodies autoantibody NNS cord-010119-t1x9gknd 7062 10 , , , cord-010119-t1x9gknd 7062 11 clinically clinically RB cord-010119-t1x9gknd 7062 12 insignificant insignificant JJ cord-010119-t1x9gknd 7062 13 antibodies antibody NNS cord-010119-t1x9gknd 7062 14 were be VBD cord-010119-t1x9gknd 7062 15 identified identify VBN cord-010119-t1x9gknd 7062 16 in in IN cord-010119-t1x9gknd 7062 17 22 22 CD cord-010119-t1x9gknd 7062 18 % % NN cord-010119-t1x9gknd 7062 19 ( ( -LRB- cord-010119-t1x9gknd 7062 20 n511 n511 NNP cord-010119-t1x9gknd 7062 21 ) ) -RRB- cord-010119-t1x9gknd 7062 22 , , , cord-010119-t1x9gknd 7062 23 4 4 CD cord-010119-t1x9gknd 7062 24 % % NN cord-010119-t1x9gknd 7062 25 ( ( -LRB- cord-010119-t1x9gknd 7062 26 n52 n52 NNP cord-010119-t1x9gknd 7062 27 ) ) -RRB- cord-010119-t1x9gknd 7062 28 , , , cord-010119-t1x9gknd 7062 29 and and CC cord-010119-t1x9gknd 7062 30 74 74 CD cord-010119-t1x9gknd 7062 31 % % NN cord-010119-t1x9gknd 7062 32 ( ( -LRB- cord-010119-t1x9gknd 7062 33 n536 n536 NNP cord-010119-t1x9gknd 7062 34 ) ) -RRB- cord-010119-t1x9gknd 7062 35 of of IN cord-010119-t1x9gknd 7062 36 the the DT cord-010119-t1x9gknd 7062 37 cases case NNS cord-010119-t1x9gknd 7062 38 , , , cord-010119-t1x9gknd 7062 39 respectively respectively RB cord-010119-t1x9gknd 7062 40 . . . cord-010119-t1x9gknd 7063 1 RBC RBC NNP cord-010119-t1x9gknd 7063 2 alloantibodies alloantibody NNS cord-010119-t1x9gknd 7063 3 identified identify VBN cord-010119-t1x9gknd 7063 4 in in IN cord-010119-t1x9gknd 7063 5 solid solid JJ cord-010119-t1x9gknd 7063 6 - - HYPH cord-010119-t1x9gknd 7063 7 phase phase NN cord-010119-t1x9gknd 7063 8 only only RB cord-010119-t1x9gknd 7063 9 included include VBD cord-010119-t1x9gknd 7063 10 anti anti JJ cord-010119-t1x9gknd 7063 11 - - JJ cord-010119-t1x9gknd 7063 12 E e JJ cord-010119-t1x9gknd 7063 13 ( ( -LRB- cord-010119-t1x9gknd 7063 14 n54 n54 NNP cord-010119-t1x9gknd 7063 15 ) ) -RRB- cord-010119-t1x9gknd 7063 16 , , , cord-010119-t1x9gknd 7063 17 anti anti JJ cord-010119-t1x9gknd 7063 18 - - NNP cord-010119-t1x9gknd 7063 19 Jka Jka NNP cord-010119-t1x9gknd 7063 20 ( ( -LRB- cord-010119-t1x9gknd 7063 21 n53 n53 NN cord-010119-t1x9gknd 7063 22 ) ) -RRB- cord-010119-t1x9gknd 7063 23 , , , cord-010119-t1x9gknd 7063 24 anti anti JJ cord-010119-t1x9gknd 7063 25 - - JJ cord-010119-t1x9gknd 7063 26 K k JJ cord-010119-t1x9gknd 7063 27 ( ( -LRB- cord-010119-t1x9gknd 7063 28 n52 n52 NNP cord-010119-t1x9gknd 7063 29 ) ) -RRB- cord-010119-t1x9gknd 7063 30 , , , cord-010119-t1x9gknd 7063 31 anti anti JJ cord-010119-t1x9gknd 7063 32 - - NNP cord-010119-t1x9gknd 7063 33 Jkb Jkb NNP cord-010119-t1x9gknd 7063 34 ( ( -LRB- cord-010119-t1x9gknd 7063 35 n51 n51 NNP cord-010119-t1x9gknd 7063 36 ) ) -RRB- cord-010119-t1x9gknd 7063 37 , , , cord-010119-t1x9gknd 7063 38 both both CC cord-010119-t1x9gknd 7063 39 anti anti JJ cord-010119-t1x9gknd 7063 40 - - JJ cord-010119-t1x9gknd 7063 41 E e JJ cord-010119-t1x9gknd 7063 42 and and CC cord-010119-t1x9gknd 7063 43 Anti Anti NNP cord-010119-t1x9gknd 7063 44 - - NNP cord-010119-t1x9gknd 7063 45 C C NNP cord-010119-t1x9gknd 7063 46 ( ( -LRB- cord-010119-t1x9gknd 7063 47 n51 n51 NN cord-010119-t1x9gknd 7063 48 ) ) -RRB- cord-010119-t1x9gknd 7063 49 ( ( -LRB- cord-010119-t1x9gknd 7063 50 see see VB cord-010119-t1x9gknd 7063 51 Table table NN cord-010119-t1x9gknd 7063 52 1 1 CD cord-010119-t1x9gknd 7063 53 ) ) -RRB- cord-010119-t1x9gknd 7063 54 . . . cord-010119-t1x9gknd 7064 1 Conclusion conclusion NN cord-010119-t1x9gknd 7064 2 : : : cord-010119-t1x9gknd 7065 1 Solid solid JJ cord-010119-t1x9gknd 7065 2 - - HYPH cord-010119-t1x9gknd 7065 3 phase phase NN cord-010119-t1x9gknd 7065 4 only only RB cord-010119-t1x9gknd 7065 5 RBC RBC NNP cord-010119-t1x9gknd 7065 6 antibodies antibody NNS cord-010119-t1x9gknd 7065 7 are be VBP cord-010119-t1x9gknd 7065 8 clinically clinically RB cord-010119-t1x9gknd 7065 9 important important JJ cord-010119-t1x9gknd 7065 10 in in IN cord-010119-t1x9gknd 7065 11 a a DT cord-010119-t1x9gknd 7065 12 significant significant JJ cord-010119-t1x9gknd 7065 13 portion portion NN cord-010119-t1x9gknd 7065 14 of of IN cord-010119-t1x9gknd 7065 15 cases case NNS cord-010119-t1x9gknd 7065 16 ( ( -LRB- cord-010119-t1x9gknd 7065 17 roughly roughly RB cord-010119-t1x9gknd 7065 18 1 1 CD cord-010119-t1x9gknd 7065 19 in in IN cord-010119-t1x9gknd 7065 20 4 4 CD cord-010119-t1x9gknd 7065 21 cases case NNS cord-010119-t1x9gknd 7065 22 ) ) -RRB- cord-010119-t1x9gknd 7065 23 . . . cord-010119-t1x9gknd 7066 1 Workup workup JJ cord-010119-t1x9gknd 7066 2 for for IN cord-010119-t1x9gknd 7066 3 solid solid JJ cord-010119-t1x9gknd 7066 4 - - HYPH cord-010119-t1x9gknd 7066 5 phase phase NN cord-010119-t1x9gknd 7066 6 only only JJ cord-010119-t1x9gknd 7066 7 antibodies antibody NNS cord-010119-t1x9gknd 7066 8 is be VBZ cord-010119-t1x9gknd 7066 9 not not RB cord-010119-t1x9gknd 7066 10 " " `` cord-010119-t1x9gknd 7066 11 unnecessary unnecessary JJ cord-010119-t1x9gknd 7066 12 " " '' cord-010119-t1x9gknd 7066 13 workload workload NN cord-010119-t1x9gknd 7066 14 . . . cord-010119-t1x9gknd 7067 1 Transfusion transfusion NN cord-010119-t1x9gknd 7067 2 of of IN cord-010119-t1x9gknd 7067 3 corresponding correspond VBG cord-010119-t1x9gknd 7067 4 antigen antigen NN cord-010119-t1x9gknd 7067 5 negative negative JJ cord-010119-t1x9gknd 7067 6 RBCs rbc NNS cord-010119-t1x9gknd 7067 7 to to IN cord-010119-t1x9gknd 7067 8 these these DT cord-010119-t1x9gknd 7067 9 patients patient NNS cord-010119-t1x9gknd 7067 10 prevented prevent VBD cord-010119-t1x9gknd 7067 11 possible possible JJ cord-010119-t1x9gknd 7067 12 hemolytic hemolytic JJ cord-010119-t1x9gknd 7067 13 transfusion transfusion NN cord-010119-t1x9gknd 7067 14 reactions reaction NNS cord-010119-t1x9gknd 7067 15 . . . cord-010119-t1x9gknd 7068 1 Full full JJ cord-010119-t1x9gknd 7068 2 - - HYPH cord-010119-t1x9gknd 7068 3 Length length NN cord-010119-t1x9gknd 7068 4 Nucleotide Nucleotide NNP cord-010119-t1x9gknd 7068 5 Sequence sequence NN cord-010119-t1x9gknd 7068 6 of of IN cord-010119-t1x9gknd 7068 7 ACKR1 ACKR1 NNP cord-010119-t1x9gknd 7069 1 Alleles allele NNS cord-010119-t1x9gknd 7069 2 Encoding encode VBG cord-010119-t1x9gknd 7069 3 Duffy Duffy NNP cord-010119-t1x9gknd 7069 4 ( ( -LRB- cord-010119-t1x9gknd 7069 5 FY FY NNP cord-010119-t1x9gknd 7069 6 ) ) -RRB- cord-010119-t1x9gknd 7069 7 Antigens antigen NNS cord-010119-t1x9gknd 7069 8 in in IN cord-010119-t1x9gknd 7069 9 Africans Africans NNPS cord-010119-t1x9gknd 7069 10 of of IN cord-010119-t1x9gknd 7069 11 Ethiopia Ethiopia NNP cord-010119-t1x9gknd 7069 12 Qinan Qinan NNP cord-010119-t1x9gknd 7069 13 Yin Yin NNP cord-010119-t1x9gknd 7069 14 * * NFP cord-010119-t1x9gknd 7069 15 , , , cord-010119-t1x9gknd 7069 16 Kshitij Kshitij NNP cord-010119-t1x9gknd 7069 17 Srivastava Srivastava NNP cord-010119-t1x9gknd 7069 18 , , , cord-010119-t1x9gknd 7069 19 Addisalem Addisalem NNP cord-010119-t1x9gknd 7069 20 Taye Taye NNP cord-010119-t1x9gknd 7069 21 - - HYPH cord-010119-t1x9gknd 7069 22 Makuria Makuria NNP cord-010119-t1x9gknd 7069 23 and and CC cord-010119-t1x9gknd 7069 24 Willy Willy NNP cord-010119-t1x9gknd 7069 25 A A NNP cord-010119-t1x9gknd 7069 26 Flegel Flegel NNP cord-010119-t1x9gknd 7069 27 . . . cord-010119-t1x9gknd 7070 1 Background Background NNP cord-010119-t1x9gknd 7070 2 / / SYM cord-010119-t1x9gknd 7070 3 Case Case NNP cord-010119-t1x9gknd 7070 4 Studies Studies NNPS cord-010119-t1x9gknd 7070 5 : : : cord-010119-t1x9gknd 7071 1 The the DT cord-010119-t1x9gknd 7071 2 human human JJ cord-010119-t1x9gknd 7071 3 ACKR1 ackr1 NN cord-010119-t1x9gknd 7071 4 gene gene NN cord-010119-t1x9gknd 7071 5 ( ( -LRB- cord-010119-t1x9gknd 7071 6 previously previously RB cord-010119-t1x9gknd 7071 7 known know VBN cord-010119-t1x9gknd 7071 8 as as IN cord-010119-t1x9gknd 7071 9 DARC DARC NNP cord-010119-t1x9gknd 7071 10 ) ) -RRB- cord-010119-t1x9gknd 7071 11 , , , cord-010119-t1x9gknd 7071 12 comprising comprise VBG cord-010119-t1x9gknd 7071 13 two two CD cord-010119-t1x9gknd 7071 14 exons exon NNS cord-010119-t1x9gknd 7071 15 and and CC cord-010119-t1x9gknd 7071 16 a a DT cord-010119-t1x9gknd 7071 17 single single JJ cord-010119-t1x9gknd 7071 18 intron intron NN cord-010119-t1x9gknd 7071 19 , , , cord-010119-t1x9gknd 7071 20 encodes encode VBZ cord-010119-t1x9gknd 7071 21 a a DT cord-010119-t1x9gknd 7071 22 multi multi JJ cord-010119-t1x9gknd 7071 23 - - JJ cord-010119-t1x9gknd 7071 24 pass pass JJ cord-010119-t1x9gknd 7071 25 trans trans NN cord-010119-t1x9gknd 7071 26 - - NN cord-010119-t1x9gknd 7071 27 membrane membrane NN cord-010119-t1x9gknd 7071 28 glycoprotein glycoprotein NN cord-010119-t1x9gknd 7071 29 expressing express VBG cord-010119-t1x9gknd 7071 30 the the DT cord-010119-t1x9gknd 7071 31 Duffy Duffy NNP cord-010119-t1x9gknd 7071 32 blood blood NN cord-010119-t1x9gknd 7071 33 group group NN cord-010119-t1x9gknd 7071 34 antigens antigen NNS cord-010119-t1x9gknd 7071 35 ( ( -LRB- cord-010119-t1x9gknd 7071 36 FY FY NNP cord-010119-t1x9gknd 7071 37 ) ) -RRB- cord-010119-t1x9gknd 7071 38 . . . cord-010119-t1x9gknd 7072 1 The the DT cord-010119-t1x9gknd 7072 2 Duffy Duffy NNP cord-010119-t1x9gknd 7072 3 protein protein NN cord-010119-t1x9gknd 7072 4 acts act VBZ cord-010119-t1x9gknd 7072 5 as as IN cord-010119-t1x9gknd 7072 6 a a DT cord-010119-t1x9gknd 7072 7 chemokine chemokine NN cord-010119-t1x9gknd 7072 8 receptor receptor NN cord-010119-t1x9gknd 7072 9 for for IN cord-010119-t1x9gknd 7072 10 various various JJ cord-010119-t1x9gknd 7072 11 proinflammatory proinflammatory JJ cord-010119-t1x9gknd 7072 12 cytokines cytokine NNS cord-010119-t1x9gknd 7072 13 and and CC cord-010119-t1x9gknd 7072 14 for for IN cord-010119-t1x9gknd 7072 15 the the DT cord-010119-t1x9gknd 7072 16 malaria malaria NN cord-010119-t1x9gknd 7072 17 parasites parasite NNS cord-010119-t1x9gknd 7072 18 Plasmodium Plasmodium NNP cord-010119-t1x9gknd 7072 19 vivax vivax NN cord-010119-t1x9gknd 7072 20 and and CC cord-010119-t1x9gknd 7072 21 P. P. NNP cord-010119-t1x9gknd 7072 22 knowlesi knowlesi NNP cord-010119-t1x9gknd 7072 23 . . . cord-010119-t1x9gknd 7073 1 The the DT cord-010119-t1x9gknd 7073 2 study study NN cord-010119-t1x9gknd 7073 3 of of IN cord-010119-t1x9gknd 7073 4 FY FY NNP cord-010119-t1x9gknd 7073 5 variants variant NNS cord-010119-t1x9gknd 7073 6 in in IN cord-010119-t1x9gknd 7073 7 the the DT cord-010119-t1x9gknd 7073 8 low low JJ cord-010119-t1x9gknd 7073 9 altitude altitude NN cord-010119-t1x9gknd 7073 10 and and CC cord-010119-t1x9gknd 7073 11 tropical tropical JJ cord-010119-t1x9gknd 7073 12 Gambela Gambela NNP cord-010119-t1x9gknd 7073 13 region region NN cord-010119-t1x9gknd 7073 14 is be VBZ cord-010119-t1x9gknd 7073 15 important important JJ cord-010119-t1x9gknd 7073 16 , , , cord-010119-t1x9gknd 7073 17 as as IN cord-010119-t1x9gknd 7073 18 malaria malaria NN cord-010119-t1x9gknd 7073 19 is be VBZ cord-010119-t1x9gknd 7073 20 endemic endemic JJ cord-010119-t1x9gknd 7073 21 and and CC cord-010119-t1x9gknd 7073 22 the the DT cord-010119-t1x9gknd 7073 23 endogenous endogenous JJ cord-010119-t1x9gknd 7073 24 population population NN cord-010119-t1x9gknd 7073 25 is be VBZ cord-010119-t1x9gknd 7073 26 living live VBG cord-010119-t1x9gknd 7073 27 in in IN cord-010119-t1x9gknd 7073 28 this this DT cord-010119-t1x9gknd 7073 29 region region NN cord-010119-t1x9gknd 7073 30 for for IN cord-010119-t1x9gknd 7073 31 a a DT cord-010119-t1x9gknd 7073 32 long long JJ cord-010119-t1x9gknd 7073 33 time time NN cord-010119-t1x9gknd 7073 34 . . . cord-010119-t1x9gknd 7074 1 In in IN cord-010119-t1x9gknd 7074 2 the the DT cord-010119-t1x9gknd 7074 3 present present JJ cord-010119-t1x9gknd 7074 4 study study NN cord-010119-t1x9gknd 7074 5 , , , cord-010119-t1x9gknd 7074 6 we -PRON- PRP cord-010119-t1x9gknd 7074 7 determined determine VBD cord-010119-t1x9gknd 7074 8 the the DT cord-010119-t1x9gknd 7074 9 full full JJ cord-010119-t1x9gknd 7074 10 length length NN cord-010119-t1x9gknd 7074 11 nucleotide nucleotide JJ cord-010119-t1x9gknd 7074 12 sequence sequence NN cord-010119-t1x9gknd 7074 13 of of IN cord-010119-t1x9gknd 7074 14 the the DT cord-010119-t1x9gknd 7074 15 ACKR1 ACKR1 NNP cord-010119-t1x9gknd 7074 16 gene gene NN cord-010119-t1x9gknd 7074 17 encoding encode VBG cord-010119-t1x9gknd 7074 18 FY FY NNP cord-010119-t1x9gknd 7074 19 antigens antigen NNS cord-010119-t1x9gknd 7074 20 in in IN cord-010119-t1x9gknd 7074 21 donors donor NNS cord-010119-t1x9gknd 7074 22 from from IN cord-010119-t1x9gknd 7074 23 Ethiopia Ethiopia NNP cord-010119-t1x9gknd 7074 24 's 's POS cord-010119-t1x9gknd 7074 25 southwestern southwestern JJ cord-010119-t1x9gknd 7074 26 Gambela Gambela NNP cord-010119-t1x9gknd 7074 27 region region NN cord-010119-t1x9gknd 7074 28 . . . cord-010119-t1x9gknd 7075 1 Study Study NNP cord-010119-t1x9gknd 7075 2 Design Design NNP cord-010119-t1x9gknd 7075 3 / / SYM cord-010119-t1x9gknd 7075 4 Method method NN cord-010119-t1x9gknd 7075 5 : : : cord-010119-t1x9gknd 7076 1 EDTA EDTA NNP cord-010119-t1x9gknd 7076 2 - - HYPH cord-010119-t1x9gknd 7076 3 anticoagulated anticoagulate VBN cord-010119-t1x9gknd 7076 4 whole whole JJ cord-010119-t1x9gknd 7076 5 blood blood NN cord-010119-t1x9gknd 7076 6 was be VBD cord-010119-t1x9gknd 7076 7 collected collect VBN cord-010119-t1x9gknd 7076 8 from from IN cord-010119-t1x9gknd 7076 9 study study NN cord-010119-t1x9gknd 7076 10 60 60 CD cord-010119-t1x9gknd 7076 11 volunteers volunteer NNS cord-010119-t1x9gknd 7076 12 in in IN cord-010119-t1x9gknd 7076 13 the the DT cord-010119-t1x9gknd 7076 14 Gambela Gambela NNP cord-010119-t1x9gknd 7076 15 region region NN cord-010119-t1x9gknd 7076 16 ( ( -LRB- cord-010119-t1x9gknd 7076 17 NCT01282021 NCT01282021 NNP cord-010119-t1x9gknd 7076 18 ) ) -RRB- cord-010119-t1x9gknd 7076 19 . . . cord-010119-t1x9gknd 7077 1 The the DT cord-010119-t1x9gknd 7077 2 whole whole JJ cord-010119-t1x9gknd 7077 3 ACKR1 ackr1 NN cord-010119-t1x9gknd 7077 4 gene gene NN cord-010119-t1x9gknd 7077 5 was be VBD cord-010119-t1x9gknd 7077 6 amplified amplify VBN cord-010119-t1x9gknd 7077 7 in in IN cord-010119-t1x9gknd 7077 8 one one CD cord-010119-t1x9gknd 7077 9 reaction reaction NN cord-010119-t1x9gknd 7077 10 covering cover VBG cord-010119-t1x9gknd 7077 11 12,125 12,125 CD cord-010119-t1x9gknd 7077 12 base base NN cord-010119-t1x9gknd 7077 13 pairs pair NNS cord-010119-t1x9gknd 7077 14 ( ( -LRB- cord-010119-t1x9gknd 7077 15 bp bp NNP cord-010119-t1x9gknd 7077 16 ) ) -RRB- cord-010119-t1x9gknd 7077 17 . . . cord-010119-t1x9gknd 7078 1 This this DT cord-010119-t1x9gknd 7078 2 primary primary JJ cord-010119-t1x9gknd 7078 3 amplicon amplicon NN cord-010119-t1x9gknd 7078 4 was be VBD cord-010119-t1x9gknd 7078 5 re re VBN cord-010119-t1x9gknd 7078 6 - - VBN cord-010119-t1x9gknd 7078 7 amplified amplify VBN cord-010119-t1x9gknd 7078 8 using use VBG cord-010119-t1x9gknd 7078 9 nested nest VBN cord-010119-t1x9gknd 7078 10 primers primer NNS cord-010119-t1x9gknd 7078 11 covering cover VBG cord-010119-t1x9gknd 7078 12 5782 5782 CD cord-010119-t1x9gknd 7078 13 nucleotides nucleotide NNS cord-010119-t1x9gknd 7078 14 . . . cord-010119-t1x9gknd 7079 1 Nucleotide nucleotide JJ cord-010119-t1x9gknd 7079 2 sequence sequence NN cord-010119-t1x9gknd 7079 3 was be VBD cord-010119-t1x9gknd 7079 4 obtained obtain VBN cord-010119-t1x9gknd 7079 5 by by IN cord-010119-t1x9gknd 7079 6 14 14 CD cord-010119-t1x9gknd 7079 7 sequencing sequencing NN cord-010119-t1x9gknd 7079 8 reactions reaction NNS cord-010119-t1x9gknd 7079 9 and and CC cord-010119-t1x9gknd 7079 10 manually manually RB cord-010119-t1x9gknd 7079 11 annotated annotate VBN cord-010119-t1x9gknd 7079 12 using use VBG cord-010119-t1x9gknd 7079 13 NCBI NCBI NNP cord-010119-t1x9gknd 7079 14 RefSeq RefSeq NNP cord-010119-t1x9gknd 7079 15 NG_011626.2 NG_011626.2 NNP cord-010119-t1x9gknd 7079 16 . . . cord-010119-t1x9gknd 7080 1 The the DT cord-010119-t1x9gknd 7080 2 sequencing sequencing NN cord-010119-t1x9gknd 7080 3 covered cover VBD cord-010119-t1x9gknd 7080 4 1008 1008 CD cord-010119-t1x9gknd 7080 5 bp bp NN cord-010119-t1x9gknd 7080 6 of of IN cord-010119-t1x9gknd 7080 7 both both DT cord-010119-t1x9gknd 7080 8 exons exon NNS cord-010119-t1x9gknd 7080 9 , , , cord-010119-t1x9gknd 7080 10 480 480 CD cord-010119-t1x9gknd 7080 11 bp bp NN cord-010119-t1x9gknd 7080 12 of of IN cord-010119-t1x9gknd 7080 13 intron intron NNP cord-010119-t1x9gknd 7080 14 , , , cord-010119-t1x9gknd 7081 1 2101 2101 CD cord-010119-t1x9gknd 7081 2 bp bp NNP cord-010119-t1x9gknd 7081 3 of of IN cord-010119-t1x9gknd 7081 4 5'-flanking 5'-flanking NNP cord-010119-t1x9gknd 7081 5 region region NN cord-010119-t1x9gknd 7081 6 , , , cord-010119-t1x9gknd 7081 7 947 947 CD cord-010119-t1x9gknd 7081 8 bp bp NNP cord-010119-t1x9gknd 7081 9 of of IN cord-010119-t1x9gknd 7081 10 5'-UTR 5'-utr CD cord-010119-t1x9gknd 7081 11 , , , cord-010119-t1x9gknd 7081 12 53 53 CD cord-010119-t1x9gknd 7081 13 bp bp NNS cord-010119-t1x9gknd 7081 14 of of IN cord-010119-t1x9gknd 7081 15 3'-UTR 3'-utr CD cord-010119-t1x9gknd 7081 16 and and CC cord-010119-t1x9gknd 7081 17 1092 1092 CD cord-010119-t1x9gknd 7081 18 bp bp NNP cord-010119-t1x9gknd 7081 19 of of IN cord-010119-t1x9gknd 7081 20 3'-flanking 3'-flanking NNP cord-010119-t1x9gknd 7081 21 region region NN cord-010119-t1x9gknd 7081 22 and and CC cord-010119-t1x9gknd 7081 23 encompassed encompass VBD cord-010119-t1x9gknd 7081 24 all all PDT cord-010119-t1x9gknd 7081 25 the the DT cord-010119-t1x9gknd 7081 26 470 470 CD cord-010119-t1x9gknd 7081 27 variations variation NNS cord-010119-t1x9gknd 7081 28 present present JJ cord-010119-t1x9gknd 7081 29 in in IN cord-010119-t1x9gknd 7081 30 dbSNP dbSNP NNP cord-010119-t1x9gknd 7081 31 and and CC cord-010119-t1x9gknd 7081 32 NHLBI NHLBI NNP cord-010119-t1x9gknd 7081 33 ESP ESP NNP cord-010119-t1x9gknd 7081 34 databases database NNS cord-010119-t1x9gknd 7081 35 . . . cord-010119-t1x9gknd 7082 1 Results result NNS cord-010119-t1x9gknd 7083 1 /Finding /finde VBG cord-010119-t1x9gknd 7083 2 : : : cord-010119-t1x9gknd 7084 1 Among among IN cord-010119-t1x9gknd 7084 2 the the DT cord-010119-t1x9gknd 7084 3 60 60 CD cord-010119-t1x9gknd 7084 4 samples sample NNS cord-010119-t1x9gknd 7084 5 , , , cord-010119-t1x9gknd 7084 6 a a DT cord-010119-t1x9gknd 7084 7 total total NN cord-010119-t1x9gknd 7084 8 of of IN cord-010119-t1x9gknd 7084 9 15 15 CD cord-010119-t1x9gknd 7084 10 SNPs snp NNS cord-010119-t1x9gknd 7084 11 , , , cord-010119-t1x9gknd 7084 12 including include VBG cord-010119-t1x9gknd 7084 13 one one CD cord-010119-t1x9gknd 7084 14 novel novel NN cord-010119-t1x9gknd 7084 15 SNP SNP NNP cord-010119-t1x9gknd 7084 16 in in IN cord-010119-t1x9gknd 7084 17 5'-UTR 5'-utr CD cord-010119-t1x9gknd 7084 18 were be VBD cord-010119-t1x9gknd 7084 19 observed observe VBN cord-010119-t1x9gknd 7084 20 . . . cord-010119-t1x9gknd 7085 1 4 4 LS cord-010119-t1x9gknd 7085 2 SNPs SNPs NNPS cord-010119-t1x9gknd 7085 3 occurred occur VBD cord-010119-t1x9gknd 7085 4 in in IN cord-010119-t1x9gknd 7085 5 the the DT cord-010119-t1x9gknd 7085 6 exons exon NNS cord-010119-t1x9gknd 7085 7 , , , cord-010119-t1x9gknd 7085 8 5 5 CD cord-010119-t1x9gknd 7085 9 in in IN cord-010119-t1x9gknd 7085 10 5'and 5'and CD cord-010119-t1x9gknd 7085 11 3'flanking 3'flanke VBG cord-010119-t1x9gknd 7085 12 region region NN cord-010119-t1x9gknd 7085 13 , , , cord-010119-t1x9gknd 7085 14 4 4 CD cord-010119-t1x9gknd 7085 15 in in IN cord-010119-t1x9gknd 7085 16 5'-UTR 5'-utr CD cord-010119-t1x9gknd 7085 17 and and CC cord-010119-t1x9gknd 7085 18 2 2 CD cord-010119-t1x9gknd 7085 19 in in IN cord-010119-t1x9gknd 7085 20 the the DT cord-010119-t1x9gknd 7085 21 intron intron NN cord-010119-t1x9gknd 7085 22 . . . cord-010119-t1x9gknd 7086 1 All all DT cord-010119-t1x9gknd 7086 2 60 60 CD cord-010119-t1x9gknd 7086 3 individuals individual NNS cord-010119-t1x9gknd 7086 4 carried carry VBD cord-010119-t1x9gknd 7086 5 the the DT cord-010119-t1x9gknd 7086 6 SNP SNP NNP cord-010119-t1x9gknd 7086 7 indicative indicative NN cord-010119-t1x9gknd 7086 8 of of IN cord-010119-t1x9gknd 7086 9 the the DT cord-010119-t1x9gknd 7086 10 common common JJ cord-010119-t1x9gknd 7086 11 FY:2 FY:2 NNP cord-010119-t1x9gknd 7086 12 phenotype phenotype NN cord-010119-t1x9gknd 7086 13 ; ; : cord-010119-t1x9gknd 7086 14 while while IN cord-010119-t1x9gknd 7086 15 58 58 CD cord-010119-t1x9gknd 7086 16 individuals individual NNS cord-010119-t1x9gknd 7086 17 were be VBD cord-010119-t1x9gknd 7086 18 homozygous homozygous JJ cord-010119-t1x9gknd 7086 19 and and CC cord-010119-t1x9gknd 7086 20 1 1 CD cord-010119-t1x9gknd 7086 21 was be VBD cord-010119-t1x9gknd 7086 22 heterozygous heterozygous JJ cord-010119-t1x9gknd 7086 23 for for IN cord-010119-t1x9gknd 7086 24 the the DT cord-010119-t1x9gknd 7086 25 GATA GATA NNP cord-010119-t1x9gknd 7086 26 box box NN cord-010119-t1x9gknd 7086 27 mutation mutation NN cord-010119-t1x9gknd 7086 28 . . . cord-010119-t1x9gknd 7087 1 No no DT cord-010119-t1x9gknd 7087 2 splice splice NN cord-010119-t1x9gknd 7087 3 site site NN cord-010119-t1x9gknd 7087 4 mutation mutation NN cord-010119-t1x9gknd 7087 5 was be VBD cord-010119-t1x9gknd 7087 6 detected detect VBN cord-010119-t1x9gknd 7087 7 . . . cord-010119-t1x9gknd 7088 1 As as IN cord-010119-t1x9gknd 7088 2 46 46 CD cord-010119-t1x9gknd 7088 3 individuals individual NNS cord-010119-t1x9gknd 7088 4 were be VBD cord-010119-t1x9gknd 7088 5 observed observe VBN cord-010119-t1x9gknd 7088 6 as as IN cord-010119-t1x9gknd 7088 7 being be VBG cord-010119-t1x9gknd 7088 8 homozygous homozygous JJ cord-010119-t1x9gknd 7088 9 or or CC cord-010119-t1x9gknd 7088 10 heterozygous heterozygous JJ cord-010119-t1x9gknd 7088 11 for for IN cord-010119-t1x9gknd 7088 12 1 1 CD cord-010119-t1x9gknd 7088 13 SNP SNP NNP cord-010119-t1x9gknd 7088 14 , , , cord-010119-t1x9gknd 7088 15 we -PRON- PRP cord-010119-t1x9gknd 7088 16 could could MD cord-010119-t1x9gknd 7088 17 unambiguously unambiguously RB cord-010119-t1x9gknd 7088 18 assign assign VB cord-010119-t1x9gknd 7088 19 8 8 CD cord-010119-t1x9gknd 7088 20 distinct distinct JJ cord-010119-t1x9gknd 7088 21 alleles allele NNS cord-010119-t1x9gknd 7088 22 . . . cord-010119-t1x9gknd 7089 1 In in IN cord-010119-t1x9gknd 7089 2 the the DT cord-010119-t1x9gknd 7089 3 remaining remain VBG cord-010119-t1x9gknd 7089 4 14 14 CD cord-010119-t1x9gknd 7089 5 individuals individual NNS cord-010119-t1x9gknd 7089 6 with with IN cord-010119-t1x9gknd 7089 7 2 2 CD cord-010119-t1x9gknd 7089 8 or or CC cord-010119-t1x9gknd 7089 9 more more RBR cord-010119-t1x9gknd 7089 10 heterozygous heterozygous JJ cord-010119-t1x9gknd 7089 11 SNPs snp NNS cord-010119-t1x9gknd 7089 12 , , , cord-010119-t1x9gknd 7089 13 allele allele NN cord-010119-t1x9gknd 7089 14 specific specific JJ cord-010119-t1x9gknd 7089 15 PCR PCR NNP cord-010119-t1x9gknd 7089 16 is be VBZ cord-010119-t1x9gknd 7089 17 required require VBN cord-010119-t1x9gknd 7089 18 to to TO cord-010119-t1x9gknd 7089 19 identify identify VB cord-010119-t1x9gknd 7089 20 the the DT cord-010119-t1x9gknd 7089 21 alleles allele NNS cord-010119-t1x9gknd 7089 22 . . . cord-010119-t1x9gknd 7090 1 Conclusion conclusion NN cord-010119-t1x9gknd 7090 2 : : : cord-010119-t1x9gknd 7090 3 We -PRON- PRP cord-010119-t1x9gknd 7090 4 sequenced sequence VBD cord-010119-t1x9gknd 7090 5 more more JJR cord-010119-t1x9gknd 7090 6 than than IN cord-010119-t1x9gknd 7090 7 5.5 5.5 CD cord-010119-t1x9gknd 7090 8 kb kb NNS cord-010119-t1x9gknd 7090 9 of of IN cord-010119-t1x9gknd 7090 10 the the DT cord-010119-t1x9gknd 7090 11 ACKR1 ACKR1 NNP cord-010119-t1x9gknd 7090 12 gene gene NN cord-010119-t1x9gknd 7090 13 and and CC cord-010119-t1x9gknd 7090 14 identified identify VBN cord-010119-t1x9gknd 7090 15 at at IN cord-010119-t1x9gknd 7090 16 least least JJS cord-010119-t1x9gknd 7090 17 8 8 CD cord-010119-t1x9gknd 7090 18 different different JJ cord-010119-t1x9gknd 7090 19 alleles allele NNS cord-010119-t1x9gknd 7090 20 . . . cord-010119-t1x9gknd 7091 1 The the DT cord-010119-t1x9gknd 7091 2 present present JJ cord-010119-t1x9gknd 7091 3 study study NN cord-010119-t1x9gknd 7091 4 found find VBD cord-010119-t1x9gknd 7091 5 that that IN cord-010119-t1x9gknd 7091 6 the the DT cord-010119-t1x9gknd 7091 7 vast vast JJ cord-010119-t1x9gknd 7091 8 majority majority NN cord-010119-t1x9gknd 7091 9 of of IN cord-010119-t1x9gknd 7091 10 alleles allele NNS cord-010119-t1x9gknd 7091 11 ( ( -LRB- cord-010119-t1x9gknd 7091 12 117/120 117/120 CD cord-010119-t1x9gknd 7091 13 ) ) -RRB- cord-010119-t1x9gknd 7091 14 in in IN cord-010119-t1x9gknd 7091 15 the the DT cord-010119-t1x9gknd 7091 16 Gambela Gambela NNP cord-010119-t1x9gknd 7091 17 population population NN cord-010119-t1x9gknd 7091 18 as as IN cord-010119-t1x9gknd 7091 19 defined define VBN cord-010119-t1x9gknd 7091 20 by by IN cord-010119-t1x9gknd 7091 21 15 15 CD cord-010119-t1x9gknd 7091 22 SNPs snp NNS cord-010119-t1x9gknd 7091 23 , , , cord-010119-t1x9gknd 7091 24 were be VBD cord-010119-t1x9gknd 7091 25 similar similar JJ cord-010119-t1x9gknd 7091 26 to to IN cord-010119-t1x9gknd 7091 27 the the DT cord-010119-t1x9gknd 7091 28 clinically clinically RB cord-010119-t1x9gknd 7091 29 relevant relevant JJ cord-010119-t1x9gknd 7091 30 FY*02N.01 fy*02n.01 CD cord-010119-t1x9gknd 7091 31 allele allele NN cord-010119-t1x9gknd 7091 32 , , , cord-010119-t1x9gknd 7091 33 which which WDT cord-010119-t1x9gknd 7091 34 in in IN cord-010119-t1x9gknd 7091 35 turn turn NN cord-010119-t1x9gknd 7091 36 is be VBZ cord-010119-t1x9gknd 7091 37 defined define VBN cord-010119-t1x9gknd 7091 38 by by IN cord-010119-t1x9gknd 7091 39 only only RB cord-010119-t1x9gknd 7091 40 2 2 CD cord-010119-t1x9gknd 7091 41 SNPs snp NNS cord-010119-t1x9gknd 7091 42 at at IN cord-010119-t1x9gknd 7091 43 positions position NNS cord-010119-t1x9gknd 7091 44 c.1 c.1 NNP cord-010119-t1x9gknd 7091 45 - - SYM cord-010119-t1x9gknd 7091 46 67 67 CD cord-010119-t1x9gknd 7091 47 T t NN cord-010119-t1x9gknd 7092 1 > > XX cord-010119-t1x9gknd 7093 1 C C NNP cord-010119-t1x9gknd 7093 2 and and CC cord-010119-t1x9gknd 7093 3 c.125 c.125 NNP cord-010119-t1x9gknd 7093 4 G g NN cord-010119-t1x9gknd 7094 1 > > XX cord-010119-t1x9gknd 7095 1 A. A. NNP cord-010119-t1x9gknd 7096 1 Out out IN cord-010119-t1x9gknd 7096 2 of of IN cord-010119-t1x9gknd 7096 3 the the DT cord-010119-t1x9gknd 7096 4 remaining remain VBG cord-010119-t1x9gknd 7096 5 3 3 CD cord-010119-t1x9gknd 7096 6 alleles allele NNS cord-010119-t1x9gknd 7096 7 , , , cord-010119-t1x9gknd 7096 8 2 2 CD cord-010119-t1x9gknd 7096 9 were be VBD cord-010119-t1x9gknd 7096 10 similar similar JJ cord-010119-t1x9gknd 7096 11 to to IN cord-010119-t1x9gknd 7096 12 FY*02 FY*02 NNP cord-010119-t1x9gknd 7096 13 with with IN cord-010119-t1x9gknd 7096 14 the the DT cord-010119-t1x9gknd 7096 15 Fy(b1 Fy(b1 NNPS cord-010119-t1x9gknd 7096 16 ) ) -RRB- cord-010119-t1x9gknd 7096 17 phenotype phenotype NN cord-010119-t1x9gknd 7096 18 and and CC cord-010119-t1x9gknd 7096 19 1 1 CD cord-010119-t1x9gknd 7096 20 was be VBD cord-010119-t1x9gknd 7096 21 similar similar JJ cord-010119-t1x9gknd 7096 22 to to IN cord-010119-t1x9gknd 7096 23 FY*02W.01 fy*02w.01 VB cord-010119-t1x9gknd 7096 24 with with IN cord-010119-t1x9gknd 7096 25 the the DT cord-010119-t1x9gknd 7096 26 Fy Fy NNP cord-010119-t1x9gknd 7096 27 x x NN cord-010119-t1x9gknd 7096 28 phenotype phenotype NN cord-010119-t1x9gknd 7096 29 . . . cord-010119-t1x9gknd 7097 1 The the DT cord-010119-t1x9gknd 7097 2 high high JJ cord-010119-t1x9gknd 7097 3 frequency frequency NN cord-010119-t1x9gknd 7097 4 of of IN cord-010119-t1x9gknd 7097 5 FY*02N.01 FY*02N.01 NNP cord-010119-t1x9gknd 7097 6 ( ( -LRB- cord-010119-t1x9gknd 7097 7 95 95 CD cord-010119-t1x9gknd 7097 8 % % NN cord-010119-t1x9gknd 7097 9 ) ) -RRB- cord-010119-t1x9gknd 7097 10 in in IN cord-010119-t1x9gknd 7097 11 this this DT cord-010119-t1x9gknd 7097 12 study study NN cord-010119-t1x9gknd 7097 13 is be VBZ cord-010119-t1x9gknd 7097 14 similar similar JJ cord-010119-t1x9gknd 7097 15 to to IN cord-010119-t1x9gknd 7097 16 other other JJ cord-010119-t1x9gknd 7097 17 studies study NNS cord-010119-t1x9gknd 7097 18 conducted conduct VBN cord-010119-t1x9gknd 7097 19 in in IN cord-010119-t1x9gknd 7097 20 Western western JJ cord-010119-t1x9gknd 7097 21 , , , cord-010119-t1x9gknd 7097 22 central central JJ cord-010119-t1x9gknd 7097 23 and and CC cord-010119-t1x9gknd 7097 24 south south JJ cord-010119-t1x9gknd 7097 25 - - HYPH cord-010119-t1x9gknd 7097 26 eastern eastern JJ cord-010119-t1x9gknd 7097 27 regions region NNS cord-010119-t1x9gknd 7097 28 from from IN cord-010119-t1x9gknd 7097 29 Gambia Gambia NNP cord-010119-t1x9gknd 7097 30 to to IN cord-010119-t1x9gknd 7097 31 Mozambique Mozambique NNP cord-010119-t1x9gknd 7097 32 ( ( -LRB- cord-010119-t1x9gknd 7097 33 95%-100 95%-100 CD cord-010119-t1x9gknd 7097 34 % % NN cord-010119-t1x9gknd 7097 35 ) ) -RRB- cord-010119-t1x9gknd 7097 36 . . . cord-010119-t1x9gknd 7098 1 A a DT cord-010119-t1x9gknd 7098 2 more more RBR cord-010119-t1x9gknd 7098 3 detailed detailed JJ cord-010119-t1x9gknd 7098 4 analysis analysis NN cord-010119-t1x9gknd 7098 5 , , , cord-010119-t1x9gknd 7098 6 including include VBG cord-010119-t1x9gknd 7098 7 other other JJ cord-010119-t1x9gknd 7098 8 regions region NNS cord-010119-t1x9gknd 7098 9 of of IN cord-010119-t1x9gknd 7098 10 Ethiopia Ethiopia NNP cord-010119-t1x9gknd 7098 11 , , , cord-010119-t1x9gknd 7098 12 will will MD cord-010119-t1x9gknd 7098 13 be be VB cord-010119-t1x9gknd 7098 14 useful useful JJ cord-010119-t1x9gknd 7098 15 to to TO cord-010119-t1x9gknd 7098 16 support support VB cord-010119-t1x9gknd 7098 17 transfusion transfusion NN cord-010119-t1x9gknd 7098 18 care care NN cord-010119-t1x9gknd 7098 19 in in IN cord-010119-t1x9gknd 7098 20 the the DT cord-010119-t1x9gknd 7098 21 US US NNP cord-010119-t1x9gknd 7098 22 for for IN cord-010119-t1x9gknd 7098 23 Ethiopian Ethiopian NNP cord-010119-t1x9gknd 7098 24 - - HYPH cord-010119-t1x9gknd 7098 25 Americans Americans NNPS cord-010119-t1x9gknd 7098 26 , , , cord-010119-t1x9gknd 7098 27 the the DT cord-010119-t1x9gknd 7098 28 majority majority NN cord-010119-t1x9gknd 7098 29 of of IN cord-010119-t1x9gknd 7098 30 whom whom WP cord-010119-t1x9gknd 7098 31 may may MD cord-010119-t1x9gknd 7098 32 be be VB cord-010119-t1x9gknd 7098 33 of of IN cord-010119-t1x9gknd 7098 34 mixed mixed JJ cord-010119-t1x9gknd 7098 35 Ethiopian ethiopian JJ cord-010119-t1x9gknd 7098 36 ethnical ethnical JJ cord-010119-t1x9gknd 7098 37 background background NN cord-010119-t1x9gknd 7098 38 . . . cord-010119-t1x9gknd 7099 1 Judith Judith NNP cord-010119-t1x9gknd 7099 2 Aeschlimann Aeschlimann NNP cord-010119-t1x9gknd 7099 3 * * NFP cord-010119-t1x9gknd 7099 4 , , , cord-010119-t1x9gknd 7099 5 Sunitha Sunitha NNP cord-010119-t1x9gknd 7099 6 Vege Vege NNP cord-010119-t1x9gknd 7099 7 , , , cord-010119-t1x9gknd 7099 8 Christine Christine NNP cord-010119-t1x9gknd 7099 9 Lomas Lomas NNP cord-010119-t1x9gknd 7099 10 - - HYPH cord-010119-t1x9gknd 7099 11 Francis Francis NNP cord-010119-t1x9gknd 7099 12 and and CC cord-010119-t1x9gknd 7099 13 Connie Connie NNP cord-010119-t1x9gknd 7099 14 M. M. NNP cord-010119-t1x9gknd 7099 15 Westhoff Westhoff NNP cord-010119-t1x9gknd 7099 16 . . . cord-010119-t1x9gknd 7100 1 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 7100 2 and and CC cord-010119-t1x9gknd 7100 3 Genomics Genomics NNPS cord-010119-t1x9gknd 7100 4 Laboratory Laboratory NNP cord-010119-t1x9gknd 7100 5 , , , cord-010119-t1x9gknd 7100 6 New New NNP cord-010119-t1x9gknd 7100 7 York York NNP cord-010119-t1x9gknd 7100 8 Blood Blood NNP cord-010119-t1x9gknd 7100 9 Center Center NNP cord-010119-t1x9gknd 7100 10 Background Background NNP cord-010119-t1x9gknd 7100 11 / / SYM cord-010119-t1x9gknd 7100 12 Case Case NNP cord-010119-t1x9gknd 7100 13 Studies Studies NNPS cord-010119-t1x9gknd 7100 14 : : : cord-010119-t1x9gknd 7101 1 The the DT cord-010119-t1x9gknd 7101 2 homology homology NN cord-010119-t1x9gknd 7101 3 , , , cord-010119-t1x9gknd 7101 4 proximity proximity NN cord-010119-t1x9gknd 7101 5 , , , cord-010119-t1x9gknd 7101 6 and and CC cord-010119-t1x9gknd 7101 7 inverted inverted JJ cord-010119-t1x9gknd 7101 8 orientation orientation NN cord-010119-t1x9gknd 7101 9 of of IN cord-010119-t1x9gknd 7101 10 RHD RHD NNP cord-010119-t1x9gknd 7101 11 and and CC cord-010119-t1x9gknd 7101 12 RHCE RHCE NNP cord-010119-t1x9gknd 7101 13 on on IN cord-010119-t1x9gknd 7101 14 the the DT cord-010119-t1x9gknd 7101 15 chromosome chromosome NN cord-010119-t1x9gknd 7101 16 favor favor VBP cord-010119-t1x9gknd 7101 17 gene gene NN cord-010119-t1x9gknd 7101 18 conversion conversion NN cord-010119-t1x9gknd 7101 19 events event NNS cord-010119-t1x9gknd 7101 20 . . . cord-010119-t1x9gknd 7102 1 Regions region NNS cord-010119-t1x9gknd 7102 2 of of IN cord-010119-t1x9gknd 7102 3 RHD RHD NNP cord-010119-t1x9gknd 7102 4 are be VBP cord-010119-t1x9gknd 7102 5 transferred transfer VBN cord-010119-t1x9gknd 7102 6 into into IN cord-010119-t1x9gknd 7102 7 RHCE RHCE NNP cord-010119-t1x9gknd 7102 8 and and CC cord-010119-t1x9gknd 7102 9 conversely conversely RB cord-010119-t1x9gknd 7102 10 , , , cord-010119-t1x9gknd 7102 11 resulting result VBG cord-010119-t1x9gknd 7102 12 in in IN cord-010119-t1x9gknd 7102 13 hybrid hybrid JJ cord-010119-t1x9gknd 7102 14 alleles allele NNS cord-010119-t1x9gknd 7102 15 that that WDT cord-010119-t1x9gknd 7102 16 encode encode VBP cord-010119-t1x9gknd 7102 17 novel novel NN cord-010119-t1x9gknd 7102 18 or or CC cord-010119-t1x9gknd 7102 19 the the DT cord-010119-t1x9gknd 7102 20 absence absence NN cord-010119-t1x9gknd 7102 21 of of IN cord-010119-t1x9gknd 7102 22 high high JJ cord-010119-t1x9gknd 7102 23 prevalence prevalence NN cord-010119-t1x9gknd 7102 24 antigens antigen NNS cord-010119-t1x9gknd 7102 25 . . . cord-010119-t1x9gknd 7103 1 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 7103 2 - - HYPH cord-010119-t1x9gknd 7103 3 CE(4 ce(4 NN cord-010119-t1x9gknd 7103 4 - - HYPH cord-010119-t1x9gknd 7103 5 7)-D 7)-d NN cord-010119-t1x9gknd 7103 6 is be VBZ cord-010119-t1x9gknd 7103 7 the the DT cord-010119-t1x9gknd 7103 8 most most RBS cord-010119-t1x9gknd 7103 9 common common JJ cord-010119-t1x9gknd 7103 10 hybrid hybrid NN cord-010119-t1x9gknd 7103 11 and and CC cord-010119-t1x9gknd 7103 12 is be VBZ cord-010119-t1x9gknd 7103 13 found find VBN cord-010119-t1x9gknd 7103 14 in in IN cord-010119-t1x9gknd 7103 15 African african JJ cord-010119-t1x9gknd 7103 16 Blacks black NNS cord-010119-t1x9gknd 7103 17 . . . cord-010119-t1x9gknd 7104 1 It -PRON- PRP cord-010119-t1x9gknd 7104 2 arose arise VBD cord-010119-t1x9gknd 7104 3 by by IN cord-010119-t1x9gknd 7104 4 conversion conversion NN cord-010119-t1x9gknd 7104 5 of of IN cord-010119-t1x9gknd 7104 6 exons exon NNS cord-010119-t1x9gknd 7104 7 4 4 CD cord-010119-t1x9gknd 7104 8 - - SYM cord-010119-t1x9gknd 7104 9 7 7 CD cord-010119-t1x9gknd 7104 10 of of IN cord-010119-t1x9gknd 7104 11 RHCE*ceS rhce*ces CD cord-010119-t1x9gknd 7104 12 into into IN cord-010119-t1x9gknd 7104 13 RHD*DIIIa RHD*DIIIa NNS cord-010119-t1x9gknd 7104 14 and and CC cord-010119-t1x9gknd 7104 15 no no RB cord-010119-t1x9gknd 7104 16 longer longer RB cord-010119-t1x9gknd 7104 17 encodes encode VBZ cord-010119-t1x9gknd 7104 18 D d NN cord-010119-t1x9gknd 7104 19 antigen antigen NN cord-010119-t1x9gknd 7104 20 , , , cord-010119-t1x9gknd 7104 21 rather rather RB cord-010119-t1x9gknd 7104 22 ( ( -LRB- cord-010119-t1x9gknd 7104 23 somewhat somewhat RB cord-010119-t1x9gknd 7104 24 confusingly confusingly RB cord-010119-t1x9gknd 7104 25 ) ) -RRB- cord-010119-t1x9gknd 7104 26 encodes encode VBZ cord-010119-t1x9gknd 7104 27 partial partial JJ cord-010119-t1x9gknd 7104 28 C C NNP cord-010119-t1x9gknd 7104 29 antigen antigen NN cord-010119-t1x9gknd 7104 30 from from IN cord-010119-t1x9gknd 7104 31 the the DT cord-010119-t1x9gknd 7104 32 RHD RHD NNP cord-010119-t1x9gknd 7104 33 locus locus NN cord-010119-t1x9gknd 7104 34 . . . cord-010119-t1x9gknd 7105 1 This this DT cord-010119-t1x9gknd 7105 2 hybrid hybrid JJ cord-010119-t1x9gknd 7105 3 allele allele NN cord-010119-t1x9gknd 7105 4 is be VBZ cord-010119-t1x9gknd 7105 5 in in IN cord-010119-t1x9gknd 7105 6 cis cis NNP cord-010119-t1x9gknd 7105 7 to to IN cord-010119-t1x9gknd 7105 8 RHCE*-ceS RHCE*-ceS NNP cord-010119-t1x9gknd 7105 9 , , , cord-010119-t1x9gknd 7105 10 together together RB cord-010119-t1x9gknd 7105 11 known know VBN cord-010119-t1x9gknd 7105 12 as as IN cord-010119-t1x9gknd 7105 13 the the DT cord-010119-t1x9gknd 7105 14 r r NNP cord-010119-t1x9gknd 7105 15 'S 'S NNP cord-010119-t1x9gknd 7105 16 haplotype haplotype NN cord-010119-t1x9gknd 7105 17 . . . cord-010119-t1x9gknd 7106 1 We -PRON- PRP cord-010119-t1x9gknd 7106 2 investigated investigate VBD cord-010119-t1x9gknd 7106 3 atypical atypical JJ cord-010119-t1x9gknd 7106 4 RH RH NNP cord-010119-t1x9gknd 7106 5 genotyping genotyping NN cord-010119-t1x9gknd 7106 6 results result NNS cord-010119-t1x9gknd 7106 7 in in IN cord-010119-t1x9gknd 7106 8 three three CD cord-010119-t1x9gknd 7106 9 samples sample NNS cord-010119-t1x9gknd 7106 10 ; ; : cord-010119-t1x9gknd 7106 11 two two CD cord-010119-t1x9gknd 7106 12 associated associate VBN cord-010119-t1x9gknd 7106 13 with with IN cord-010119-t1x9gknd 7106 14 weak weak JJ cord-010119-t1x9gknd 7106 15 D d NN cord-010119-t1x9gknd 7106 16 typing typing NN cord-010119-t1x9gknd 7106 17 and and CC cord-010119-t1x9gknd 7106 18 one one CD cord-010119-t1x9gknd 7106 19 patient patient NN cord-010119-t1x9gknd 7106 20 with with IN cord-010119-t1x9gknd 7106 21 sickle sickle NN cord-010119-t1x9gknd 7106 22 cell cell NN cord-010119-t1x9gknd 7106 23 disease disease NN cord-010119-t1x9gknd 7106 24 ( ( -LRB- cord-010119-t1x9gknd 7106 25 SCD SCD NNP cord-010119-t1x9gknd 7106 26 ) ) -RRB- cord-010119-t1x9gknd 7106 27 . . . cord-010119-t1x9gknd 7107 1 Study Study NNP cord-010119-t1x9gknd 7107 2 Design Design NNP cord-010119-t1x9gknd 7107 3 / / SYM cord-010119-t1x9gknd 7107 4 Method method NN cord-010119-t1x9gknd 7107 5 : : : cord-010119-t1x9gknd 7108 1 Serologic Serologic NNP cord-010119-t1x9gknd 7108 2 testing testing NN cord-010119-t1x9gknd 7108 3 was be VBD cord-010119-t1x9gknd 7108 4 by by IN cord-010119-t1x9gknd 7108 5 standard standard JJ cord-010119-t1x9gknd 7108 6 methods method NNS cord-010119-t1x9gknd 7108 7 . . . cord-010119-t1x9gknd 7109 1 Genomic genomic JJ cord-010119-t1x9gknd 7109 2 DNA dna NN cord-010119-t1x9gknd 7109 3 was be VBD cord-010119-t1x9gknd 7109 4 isolated isolate VBN cord-010119-t1x9gknd 7109 5 from from IN cord-010119-t1x9gknd 7109 6 WBCs wbc NNS cord-010119-t1x9gknd 7109 7 . . . cord-010119-t1x9gknd 7110 1 All all DT cord-010119-t1x9gknd 7110 2 samples sample NNS cord-010119-t1x9gknd 7110 3 were be VBD cord-010119-t1x9gknd 7110 4 investigated investigate VBN cord-010119-t1x9gknd 7110 5 by by IN cord-010119-t1x9gknd 7110 6 HEA HEA NNP cord-010119-t1x9gknd 7110 7 PreciseType PreciseType NNP cord-010119-t1x9gknd 7110 8 , , , cord-010119-t1x9gknd 7110 9 RHD RHD NNP cord-010119-t1x9gknd 7110 10 and and CC cord-010119-t1x9gknd 7110 11 RHCE RHCE NNP cord-010119-t1x9gknd 7110 12 BeadChip BeadChip NNP cord-010119-t1x9gknd 7110 13 , , , cord-010119-t1x9gknd 7110 14 RFLP RFLP NNP cord-010119-t1x9gknd 7110 15 , , , cord-010119-t1x9gknd 7110 16 and and CC cord-010119-t1x9gknd 7110 17 Rh Rh NNP cord-010119-t1x9gknd 7110 18 - - HYPH cord-010119-t1x9gknd 7110 19 cDNA cdna NN cord-010119-t1x9gknd 7110 20 sequencing sequencing NN cord-010119-t1x9gknd 7110 21 . . . cord-010119-t1x9gknd 7111 1 SNP SNP NNP cord-010119-t1x9gknd 7111 2 - - HYPH cord-010119-t1x9gknd 7111 3 specific specific JJ cord-010119-t1x9gknd 7111 4 sequencing sequencing NN cord-010119-t1x9gknd 7111 5 was be VBD cord-010119-t1x9gknd 7111 6 used use VBN cord-010119-t1x9gknd 7111 7 to to TO cord-010119-t1x9gknd 7111 8 establish establish VB cord-010119-t1x9gknd 7111 9 linkage linkage NN cord-010119-t1x9gknd 7111 10 / / SYM cord-010119-t1x9gknd 7111 11 phasing phasing NN cord-010119-t1x9gknd 7111 12 . . . cord-010119-t1x9gknd 7112 1 Results result NNS cord-010119-t1x9gknd 7113 1 /Finding /finde VBG cord-010119-t1x9gknd 7113 2 : : : cord-010119-t1x9gknd 7113 3 Sample sample NN cord-010119-t1x9gknd 7113 4 1 1 CD cord-010119-t1x9gknd 7113 5 ( ( -LRB- cord-010119-t1x9gknd 7113 6 male male NN cord-010119-t1x9gknd 7113 7 ) ) -RRB- cord-010119-t1x9gknd 7113 8 and and CC cord-010119-t1x9gknd 7113 9 sample sample NN cord-010119-t1x9gknd 7113 10 2 2 CD cord-010119-t1x9gknd 7113 11 ( ( -LRB- cord-010119-t1x9gknd 7113 12 multiracial multiracial JJ cord-010119-t1x9gknd 7113 13 female female NN cord-010119-t1x9gknd 7113 14 ) ) -RRB- cord-010119-t1x9gknd 7113 15 , , , cord-010119-t1x9gknd 7113 16 both both DT cord-010119-t1x9gknd 7113 17 C1c2E2e1 C1c2E2e1 NNP cord-010119-t1x9gknd 7113 18 ( ( -LRB- cord-010119-t1x9gknd 7113 19 presumed presume VBN cord-010119-t1x9gknd 7113 20 R1R1 R1R1 NNP cord-010119-t1x9gknd 7113 21 ) ) -RRB- cord-010119-t1x9gknd 7113 22 , , , cord-010119-t1x9gknd 7113 23 presented present VBN cord-010119-t1x9gknd 7113 24 with with IN cord-010119-t1x9gknd 7113 25 weaker weak JJR cord-010119-t1x9gknd 7113 26 than than IN cord-010119-t1x9gknd 7113 27 expected expect VBN cord-010119-t1x9gknd 7113 28 D D NNP cord-010119-t1x9gknd 7113 29 _SP cord-010119-t1x9gknd 7113 30 typing typing NN cord-010119-t1x9gknd 7113 31 ; ; . cord-010119-t1x9gknd 7114 1 11 11 CD cord-010119-t1x9gknd 7114 2 IS be VBZ cord-010119-t1x9gknd 7114 3 and and CC cord-010119-t1x9gknd 7114 4 31/41 31/41 CD cord-010119-t1x9gknd 7114 5 at at IN cord-010119-t1x9gknd 7114 6 IAT IAT NNP cord-010119-t1x9gknd 7114 7 . . . cord-010119-t1x9gknd 7115 1 RHD RHD NNP cord-010119-t1x9gknd 7115 2 BeadChip BeadChip NNP cord-010119-t1x9gknd 7115 3 identified identify VBD cord-010119-t1x9gknd 7115 4 the the DT cord-010119-t1x9gknd 7115 5 common common JJ cord-010119-t1x9gknd 7115 6 African african JJ cord-010119-t1x9gknd 7115 7 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 7115 8 - - HYPH cord-010119-t1x9gknd 7115 9 CE(4 ce(4 NN cord-010119-t1x9gknd 7115 10 - - HYPH cord-010119-t1x9gknd 7115 11 7)-D 7)-d NN cord-010119-t1x9gknd 7115 12 hybrid hybrid NN cord-010119-t1x9gknd 7115 13 encoding encoding NN cord-010119-t1x9gknd 7115 14 partial partial JJ cord-010119-t1x9gknd 7115 15 C c NN cord-010119-t1x9gknd 7115 16 antigen antigen NN cord-010119-t1x9gknd 7115 17 with with IN cord-010119-t1x9gknd 7115 18 apparent apparent JJ cord-010119-t1x9gknd 7115 19 conventional conventional JJ cord-010119-t1x9gknd 7115 20 RHD RHD NNP cord-010119-t1x9gknd 7115 21 in in IN cord-010119-t1x9gknd 7115 22 trans trans NNP cord-010119-t1x9gknd 7115 23 . . . cord-010119-t1x9gknd 7116 1 These these DT cord-010119-t1x9gknd 7116 2 results result NNS cord-010119-t1x9gknd 7116 3 did do VBD cord-010119-t1x9gknd 7116 4 not not RB cord-010119-t1x9gknd 7116 5 provide provide VB cord-010119-t1x9gknd 7116 6 an an DT cord-010119-t1x9gknd 7116 7 explanation explanation NN cord-010119-t1x9gknd 7116 8 for for IN cord-010119-t1x9gknd 7116 9 weak weak JJ cord-010119-t1x9gknd 7116 10 D D NNP cord-010119-t1x9gknd 7116 11 antigen antigen NN cord-010119-t1x9gknd 7116 12 . . . cord-010119-t1x9gknd 7117 1 HEA HEA NNP cord-010119-t1x9gknd 7117 2 indicated indicate VBD cord-010119-t1x9gknd 7117 3 RHCE*Ce RHCE*Ce NNP cord-010119-t1x9gknd 7117 4 /Ce /Ce . cord-010119-t1x9gknd 7118 1 , , , cord-010119-t1x9gknd 7118 2 concordant concordant JJ cord-010119-t1x9gknd 7118 3 with with IN cord-010119-t1x9gknd 7118 4 the the DT cord-010119-t1x9gknd 7118 5 Rh Rh NNP cord-010119-t1x9gknd 7118 6 phenotype phenotype NN cord-010119-t1x9gknd 7118 7 , , , cord-010119-t1x9gknd 7118 8 but but CC cord-010119-t1x9gknd 7118 9 c.733C c.733C NNP cord-010119-t1x9gknd 7119 1 > > XX cord-010119-t1x9gknd 7120 1 G g NN cord-010119-t1x9gknd 7120 2 and and CC cord-010119-t1x9gknd 7120 3 c.1006 c.1006 NN cord-010119-t1x9gknd 7120 4 G g NN cord-010119-t1x9gknd 7120 5 > > XX cord-010119-t1x9gknd 7121 1 T T NNP cord-010119-t1x9gknd 7121 2 ( ( -LRB- cord-010119-t1x9gknd 7121 3 heterozygous heterozygous NNP cord-010119-t1x9gknd 7121 4 ) ) -RRB- cord-010119-t1x9gknd 7121 5 was be VBD cord-010119-t1x9gknd 7121 6 also also RB cord-010119-t1x9gknd 7121 7 detected detect VBN cord-010119-t1x9gknd 7121 8 . . . cord-010119-t1x9gknd 7122 1 As as IN cord-010119-t1x9gknd 7122 2 RHCE*Ce rhce*ce JJ cord-010119-t1x9gknd 7122 3 with with IN cord-010119-t1x9gknd 7122 4 733 733 CD cord-010119-t1x9gknd 7122 5 G g NN cord-010119-t1x9gknd 7122 6 and and CC cord-010119-t1x9gknd 7122 7 1006 1006 CD cord-010119-t1x9gknd 7122 8 T T NNP cord-010119-t1x9gknd 7122 9 has have VBZ cord-010119-t1x9gknd 7122 10 not not RB cord-010119-t1x9gknd 7122 11 been be VBN cord-010119-t1x9gknd 7122 12 reported report VBN cord-010119-t1x9gknd 7122 13 , , , cord-010119-t1x9gknd 7122 14 Rh Rh NNP cord-010119-t1x9gknd 7122 15 - - HYPH cord-010119-t1x9gknd 7122 16 cDNA cdna NN cord-010119-t1x9gknd 7122 17 analysis analysis NN cord-010119-t1x9gknd 7122 18 was be VBD cord-010119-t1x9gknd 7122 19 done do VBN cord-010119-t1x9gknd 7122 20 . . . cord-010119-t1x9gknd 7123 1 Transcripts transcript NNS cord-010119-t1x9gknd 7123 2 from from IN cord-010119-t1x9gknd 7123 3 the the DT cord-010119-t1x9gknd 7123 4 RHCE RHCE NNP cord-010119-t1x9gknd 7123 5 locus locus NN cord-010119-t1x9gknd 7123 6 included include VBD cord-010119-t1x9gknd 7123 7 one one CD cord-010119-t1x9gknd 7123 8 conventional conventional JJ cord-010119-t1x9gknd 7123 9 RHCE*Ce rhce*ce NN cord-010119-t1x9gknd 7123 10 in in IN cord-010119-t1x9gknd 7123 11 trans trans NNP cord-010119-t1x9gknd 7123 12 to to IN cord-010119-t1x9gknd 7123 13 RHCE*ceS rhce*ces CD cord-010119-t1x9gknd 7123 14 with with IN cord-010119-t1x9gknd 7123 15 exons exon NNS cord-010119-t1x9gknd 7123 16 2 2 CD cord-010119-t1x9gknd 7123 17 and and CC cord-010119-t1x9gknd 7123 18 3 3 CD cord-010119-t1x9gknd 7123 19 replaced replace VBD cord-010119-t1x9gknd 7123 20 with with IN cord-010119-t1x9gknd 7123 21 RHD*DIIIa RHD*DIIIa NNS cord-010119-t1x9gknd 7123 22 , , , cord-010119-t1x9gknd 7123 23 and and CC cord-010119-t1x9gknd 7123 24 from from IN cord-010119-t1x9gknd 7123 25 the the DT cord-010119-t1x9gknd 7123 26 RHD RHD NNP cord-010119-t1x9gknd 7123 27 locus locus NN cord-010119-t1x9gknd 7123 28 , , , cord-010119-t1x9gknd 7123 29 one one CD cord-010119-t1x9gknd 7123 30 conventional conventional JJ cord-010119-t1x9gknd 7123 31 RHD RHD NNP cord-010119-t1x9gknd 7123 32 and and CC cord-010119-t1x9gknd 7123 33 the the DT cord-010119-t1x9gknd 7123 34 hybrid hybrid JJ cord-010119-t1x9gknd 7123 35 RHD RHD NNP cord-010119-t1x9gknd 7123 36 * * NFP cord-010119-t1x9gknd 7123 37 DIIIa DIIIa NNS cord-010119-t1x9gknd 7123 38 - - HYPH cord-010119-t1x9gknd 7123 39 CE(4 ce(4 NN cord-010119-t1x9gknd 7123 40 - - HYPH cord-010119-t1x9gknd 7123 41 7)-D 7)-D NNP cord-010119-t1x9gknd 7123 42 were be VBD cord-010119-t1x9gknd 7123 43 found find VBN cord-010119-t1x9gknd 7123 44 in in IN cord-010119-t1x9gknd 7123 45 both both DT cord-010119-t1x9gknd 7123 46 samples sample NNS cord-010119-t1x9gknd 7123 47 . . . cord-010119-t1x9gknd 7124 1 Sample sample NN cord-010119-t1x9gknd 7124 2 3 3 CD cord-010119-t1x9gknd 7124 3 ( ( -LRB- cord-010119-t1x9gknd 7124 4 SCD SCD NNP cord-010119-t1x9gknd 7124 5 male male NN cord-010119-t1x9gknd 7124 6 ) ) -RRB- cord-010119-t1x9gknd 7124 7 , , , cord-010119-t1x9gknd 7124 8 D1C2E2c1e1 D1C2E2c1e1 NNP cord-010119-t1x9gknd 7124 9 , , , cord-010119-t1x9gknd 7124 10 by by IN cord-010119-t1x9gknd 7124 11 RH RH NNP cord-010119-t1x9gknd 7124 12 beadchip beadchip NNP cord-010119-t1x9gknd 7124 13 had have VBD cord-010119-t1x9gknd 7124 14 one one CD cord-010119-t1x9gknd 7124 15 conventional conventional JJ cord-010119-t1x9gknd 7124 16 RHD rhd NN cord-010119-t1x9gknd 7124 17 and and CC cord-010119-t1x9gknd 7124 18 RHD*DIII rhd*diii NN cord-010119-t1x9gknd 7124 19 type type NN cord-010119-t1x9gknd 7124 20 8 8 CD cord-010119-t1x9gknd 7124 21 , , , cord-010119-t1x9gknd 7124 22 and and CC cord-010119-t1x9gknd 7124 23 RHCE*ce733G RHCE*ce733G NNP cord-010119-t1x9gknd 7124 24 / / SYM cord-010119-t1x9gknd 7124 25 ceS. ceS. NNP cord-010119-t1x9gknd 7125 1 As as IN cord-010119-t1x9gknd 7125 2 RHD*DIIIa rhd*diiia NN cord-010119-t1x9gknd 7125 3 type type NN cord-010119-t1x9gknd 7125 4 8 8 CD cord-010119-t1x9gknd 7125 5 has have VBZ cord-010119-t1x9gknd 7125 6 never never RB cord-010119-t1x9gknd 7125 7 been be VBN cord-010119-t1x9gknd 7125 8 found find VBN cord-010119-t1x9gknd 7125 9 with with IN cord-010119-t1x9gknd 7125 10 either either DT cord-010119-t1x9gknd 7125 11 of of IN cord-010119-t1x9gknd 7125 12 these these DT cord-010119-t1x9gknd 7125 13 RHCE RHCE NNP cord-010119-t1x9gknd 7125 14 alleles allele NNS cord-010119-t1x9gknd 7125 15 , , , cord-010119-t1x9gknd 7125 16 Rh Rh NNP cord-010119-t1x9gknd 7125 17 - - HYPH cord-010119-t1x9gknd 7125 18 cDNA cdna NN cord-010119-t1x9gknd 7125 19 analysis analysis NN cord-010119-t1x9gknd 7125 20 was be VBD cord-010119-t1x9gknd 7125 21 performed perform VBN cord-010119-t1x9gknd 7125 22 . . . cord-010119-t1x9gknd 7126 1 Transcripts transcript NNS cord-010119-t1x9gknd 7126 2 representing represent VBG cord-010119-t1x9gknd 7126 3 a a DT cord-010119-t1x9gknd 7126 4 unique unique JJ cord-010119-t1x9gknd 7126 5 conversion conversion NN cord-010119-t1x9gknd 7126 6 event event NN cord-010119-t1x9gknd 7126 7 at at IN cord-010119-t1x9gknd 7126 8 the the DT cord-010119-t1x9gknd 7126 9 RHD RHD NNP cord-010119-t1x9gknd 7126 10 locus locus NN cord-010119-t1x9gknd 7126 11 , , , cord-010119-t1x9gknd 7126 12 specifically specifically RB cord-010119-t1x9gknd 7126 13 RHCE*ce(48C rhce*ce(48c NN cord-010119-t1x9gknd 7126 14 ) ) -RRB- cord-010119-t1x9gknd 7126 15 exons exon NNS cord-010119-t1x9gknd 7126 16 1 1 CD cord-010119-t1x9gknd 7126 17 and and CC cord-010119-t1x9gknd 7126 18 2 2 CD cord-010119-t1x9gknd 7126 19 had have VBD cord-010119-t1x9gknd 7126 20 replaced replace VBN cord-010119-t1x9gknd 7126 21 those those DT cord-010119-t1x9gknd 7126 22 exons exon NNS cord-010119-t1x9gknd 7126 23 in in IN cord-010119-t1x9gknd 7126 24 the the DT cord-010119-t1x9gknd 7126 25 common common JJ cord-010119-t1x9gknd 7126 26 hybrid hybrid JJ cord-010119-t1x9gknd 7126 27 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 7126 28 - - HYPH cord-010119-t1x9gknd 7126 29 CE(4 ce(4 NN cord-010119-t1x9gknd 7126 30 - - HYPH cord-010119-t1x9gknd 7126 31 7)-D 7)-d NN cord-010119-t1x9gknd 7126 32 and and CC cord-010119-t1x9gknd 7126 33 expression expression NN cord-010119-t1x9gknd 7126 34 of of IN cord-010119-t1x9gknd 7126 35 partial partial JJ cord-010119-t1x9gknd 7126 36 C c NN cord-010119-t1x9gknd 7126 37 antigen antigen NN cord-010119-t1x9gknd 7126 38 was be VBD cord-010119-t1x9gknd 7126 39 lost lose VBN cord-010119-t1x9gknd 7126 40 These these DT cord-010119-t1x9gknd 7126 41 unique unique JJ cord-010119-t1x9gknd 7126 42 hybrid hybrid JJ cord-010119-t1x9gknd 7126 43 alleles allele NNS cord-010119-t1x9gknd 7126 44 have have VBP cord-010119-t1x9gknd 7126 45 been be VBN cord-010119-t1x9gknd 7126 46 deposited deposit VBN cord-010119-t1x9gknd 7126 47 as as IN cord-010119-t1x9gknd 7126 48 GenBank GenBank NNP cord-010119-t1x9gknd 7126 49 # # NN cord-010119-t1x9gknd 7126 50 : : : cord-010119-t1x9gknd 7126 51 KY926711and KY926711and NNP cord-010119-t1x9gknd 7126 52 KY926710 KY926710 NNS cord-010119-t1x9gknd 7126 53 . . . cord-010119-t1x9gknd 7127 1 We -PRON- PRP cord-010119-t1x9gknd 7127 2 report report VBP cord-010119-t1x9gknd 7127 3 two two CD cord-010119-t1x9gknd 7127 4 different different JJ cord-010119-t1x9gknd 7127 5 and and CC cord-010119-t1x9gknd 7127 6 novel novel JJ cord-010119-t1x9gknd 7127 7 complex complex JJ cord-010119-t1x9gknd 7127 8 RH RH NNP cord-010119-t1x9gknd 7127 9 rearrangements rearrangement NNS cord-010119-t1x9gknd 7127 10 : : : cord-010119-t1x9gknd 7127 11 two two CD cord-010119-t1x9gknd 7127 12 samples sample NNS cord-010119-t1x9gknd 7127 13 thought think VBN cord-010119-t1x9gknd 7127 14 to to TO cord-010119-t1x9gknd 7127 15 be be VB cord-010119-t1x9gknd 7127 16 R1R1 R1R1 NNP cord-010119-t1x9gknd 7127 17 had have VBD cord-010119-t1x9gknd 7127 18 a a DT cord-010119-t1x9gknd 7127 19 unique unique JJ cord-010119-t1x9gknd 7127 20 RHCE RHCE NNP cord-010119-t1x9gknd 7127 21 locus locus NN cord-010119-t1x9gknd 7127 22 representing represent VBG cord-010119-t1x9gknd 7127 23 a a DT cord-010119-t1x9gknd 7127 24 gene gene NN cord-010119-t1x9gknd 7127 25 conversion conversion NN cord-010119-t1x9gknd 7127 26 into into IN cord-010119-t1x9gknd 7127 27 RHCE*ceS rhce*ces CD cord-010119-t1x9gknd 7127 28 , , , cord-010119-t1x9gknd 7127 29 designated designate VBN cord-010119-t1x9gknd 7127 30 RHCE*ceS RHCE*ceS NNPS cord-010119-t1x9gknd 7127 31 - - HYPH cord-010119-t1x9gknd 7127 32 DIIIa(2 DIIIa(2 NNS cord-010119-t1x9gknd 7127 33 - - HYPH cord-010119-t1x9gknd 7127 34 3)-ce 3)-ce CD cord-010119-t1x9gknd 7127 35 . . . cord-010119-t1x9gknd 7128 1 In in IN cord-010119-t1x9gknd 7128 2 kind kind NN cord-010119-t1x9gknd 7128 3 , , , cord-010119-t1x9gknd 7128 4 a a DT cord-010119-t1x9gknd 7128 5 sample sample NN cord-010119-t1x9gknd 7128 6 genotyped genotype VBN cord-010119-t1x9gknd 7128 7 as as IN cord-010119-t1x9gknd 7128 8 DIII DIII NNP cord-010119-t1x9gknd 7128 9 type type NN cord-010119-t1x9gknd 7128 10 8 8 CD cord-010119-t1x9gknd 7128 11 rather rather RB cord-010119-t1x9gknd 7128 12 had have VBD cord-010119-t1x9gknd 7128 13 a a DT cord-010119-t1x9gknd 7128 14 novel novel JJ cord-010119-t1x9gknd 7128 15 RHD RHD NNP cord-010119-t1x9gknd 7128 16 locus locus NN cord-010119-t1x9gknd 7128 17 representing represent VBG cord-010119-t1x9gknd 7128 18 a a DT cord-010119-t1x9gknd 7128 19 gene gene NN cord-010119-t1x9gknd 7128 20 conversion conversion NN cord-010119-t1x9gknd 7128 21 into into IN cord-010119-t1x9gknd 7128 22 the the DT cord-010119-t1x9gknd 7128 23 common common JJ cord-010119-t1x9gknd 7128 24 hybrid hybrid NN cord-010119-t1x9gknd 7128 25 , , , cord-010119-t1x9gknd 7128 26 designated designate VBN cord-010119-t1x9gknd 7128 27 as as IN cord-010119-t1x9gknd 7128 28 RHD*ce48C(1 rhd*ce48c(1 JJ cord-010119-t1x9gknd 7128 29 - - HYPH cord-010119-t1x9gknd 7128 30 2)-DIIIa(3)-ceS(4 2)-diiia(3)-ces(4 CD cord-010119-t1x9gknd 7128 31 - - HYPH cord-010119-t1x9gknd 7128 32 7)-D 7)-d NN cord-010119-t1x9gknd 7128 33 . . . cord-010119-t1x9gknd 7129 1 These these DT cord-010119-t1x9gknd 7129 2 represent represent VBP cord-010119-t1x9gknd 7129 3 novel novel JJ cord-010119-t1x9gknd 7129 4 events event NNS cord-010119-t1x9gknd 7129 5 on on IN cord-010119-t1x9gknd 7129 6 the the DT cord-010119-t1x9gknd 7129 7 r r NN cord-010119-t1x9gknd 7129 8 'S 'S NNP cord-010119-t1x9gknd 7129 9 haplotype haplotype NN cord-010119-t1x9gknd 7129 10 that that WDT cord-010119-t1x9gknd 7129 11 can can MD cord-010119-t1x9gknd 7129 12 confound confound VB cord-010119-t1x9gknd 7129 13 RH RH NNP cord-010119-t1x9gknd 7129 14 genotyping genotyping NN cord-010119-t1x9gknd 7129 15 interpretations interpretation NNS cord-010119-t1x9gknd 7129 16 . . . cord-010119-t1x9gknd 7130 1 Interestingly interestingly RB cord-010119-t1x9gknd 7130 2 , , , cord-010119-t1x9gknd 7130 3 samples sample VBZ cord-010119-t1x9gknd 7130 4 2 2 CD cord-010119-t1x9gknd 7130 5 and and CC cord-010119-t1x9gknd 7130 6 3 3 CD cord-010119-t1x9gknd 7130 7 have have VBP cord-010119-t1x9gknd 7130 8 weaker weak JJR cord-010119-t1x9gknd 7130 9 than than IN cord-010119-t1x9gknd 7130 10 expected expect VBN cord-010119-t1x9gknd 7130 11 D d NN cord-010119-t1x9gknd 7130 12 antigen antigen NN cord-010119-t1x9gknd 7130 13 typing typing NN cord-010119-t1x9gknd 7130 14 , , , cord-010119-t1x9gknd 7130 15 despite despite IN cord-010119-t1x9gknd 7130 16 the the DT cord-010119-t1x9gknd 7130 17 presence presence NN cord-010119-t1x9gknd 7130 18 of of IN cord-010119-t1x9gknd 7130 19 a a DT cord-010119-t1x9gknd 7130 20 conventional conventional JJ cord-010119-t1x9gknd 7130 21 RHD rhd NN cord-010119-t1x9gknd 7130 22 with with IN cord-010119-t1x9gknd 7130 23 RHCE*Ce rhce*ce NN cord-010119-t1x9gknd 7130 24 [ [ -LRB- cord-010119-t1x9gknd 7130 25 R1 r1 NN cord-010119-t1x9gknd 7130 26 haplotype haplotype NN cord-010119-t1x9gknd 7130 27 ( ( -LRB- cord-010119-t1x9gknd 7130 28 DCe DCe NNP cord-010119-t1x9gknd 7130 29 ) ) -RRB- cord-010119-t1x9gknd 7130 30 ] ] -RRB- cord-010119-t1x9gknd 7130 31 . . . cord-010119-t1x9gknd 7131 1 It -PRON- PRP cord-010119-t1x9gknd 7131 2 is be VBZ cord-010119-t1x9gknd 7131 3 important important JJ cord-010119-t1x9gknd 7131 4 to to TO cord-010119-t1x9gknd 7131 5 further further RB cord-010119-t1x9gknd 7131 6 investigate investigate VB cord-010119-t1x9gknd 7131 7 samples sample NNS cord-010119-t1x9gknd 7131 8 with with IN cord-010119-t1x9gknd 7131 9 unconventional unconventional JJ cord-010119-t1x9gknd 7131 10 results result NNS cord-010119-t1x9gknd 7131 11 when when WRB cord-010119-t1x9gknd 7131 12 interpreting interpret VBG cord-010119-t1x9gknd 7131 13 RH RH NNP cord-010119-t1x9gknd 7131 14 genotypes genotype NNS cord-010119-t1x9gknd 7131 15 . . . cord-010119-t1x9gknd 7132 1 High high JJ cord-010119-t1x9gknd 7132 2 - - HYPH cord-010119-t1x9gknd 7132 3 Frequency Frequency NNP cord-010119-t1x9gknd 7132 4 Antibodies Antibodies NNP cord-010119-t1x9gknd 7132 5 Anti Anti NNP cord-010119-t1x9gknd 7132 6 - - NNP cord-010119-t1x9gknd 7132 7 Lu(b- lu(b- JJ cord-010119-t1x9gknd 7132 8 ) ) -RRB- cord-010119-t1x9gknd 7132 9 and and CC cord-010119-t1x9gknd 7132 10 Anti Anti NNP cord-010119-t1x9gknd 7132 11 - - NNP cord-010119-t1x9gknd 7132 12 Yt(a- yt(a- CD cord-010119-t1x9gknd 7132 13 ) ) -RRB- cord-010119-t1x9gknd 7132 14 in in IN cord-010119-t1x9gknd 7132 15 a a DT cord-010119-t1x9gknd 7132 16 Multi Multi NNP cord-010119-t1x9gknd 7132 17 - - HYPH cord-010119-t1x9gknd 7132 18 Transfused transfused JJ cord-010119-t1x9gknd 7132 19 Patient Patient NNP cord-010119-t1x9gknd 7132 20 : : : cord-010119-t1x9gknd 7133 1 A a DT cord-010119-t1x9gknd 7133 2 Case Case NNP cord-010119-t1x9gknd 7133 3 Study Study NNP cord-010119-t1x9gknd 7133 4 Nadia Nadia NNP cord-010119-t1x9gknd 7133 5 Baillargeon Baillargeon NNP cord-010119-t1x9gknd 7133 6 * * NFP cord-010119-t1x9gknd 7133 7 , , , cord-010119-t1x9gknd 7133 8 Carole Carole NNP cord-010119-t1x9gknd 7133 9 Ethier Ethier NNP cord-010119-t1x9gknd 7133 10 , , , cord-010119-t1x9gknd 7133 11 Cynthia Cynthia NNP cord-010119-t1x9gknd 7133 12 Parent Parent NNP cord-010119-t1x9gknd 7133 13 , , , cord-010119-t1x9gknd 7133 14 Jessica Jessica NNP cord-010119-t1x9gknd 7133 15 Constanzo Constanzo NNP cord-010119-t1x9gknd 7133 16 - - HYPH cord-010119-t1x9gknd 7133 17 Yanez Yanez NNP cord-010119-t1x9gknd 7133 18 , , , cord-010119-t1x9gknd 7133 19 Maryse Maryse NNP cord-010119-t1x9gknd 7133 20 St St NNP cord-010119-t1x9gknd 7133 21 - - HYPH cord-010119-t1x9gknd 7133 22 Louis Louis NNP cord-010119-t1x9gknd 7133 23 , , , cord-010119-t1x9gknd 7133 24 Marie Marie NNP cord-010119-t1x9gknd 7133 25 - - HYPH cord-010119-t1x9gknd 7133 26 Claire Claire NNP cord-010119-t1x9gknd 7133 27 Chevrier Chevrier NNP cord-010119-t1x9gknd 7133 28 and and CC cord-010119-t1x9gknd 7133 29 Andre Andre NNP cord-010119-t1x9gknd 7133 30 Lebrun Lebrun NNP cord-010119-t1x9gknd 7133 31 . . . cord-010119-t1x9gknd 7134 1 Hema Hema NNP cord-010119-t1x9gknd 7134 2 - - HYPH cord-010119-t1x9gknd 7134 3 Quebec Quebec NNP cord-010119-t1x9gknd 7134 4 Background Background NNP cord-010119-t1x9gknd 7134 5 / / SYM cord-010119-t1x9gknd 7134 6 Case Case NNP cord-010119-t1x9gknd 7134 7 Studies Studies NNPS cord-010119-t1x9gknd 7134 8 : : : cord-010119-t1x9gknd 7135 1 A a DT cord-010119-t1x9gknd 7135 2 81-year 81-year JJ cord-010119-t1x9gknd 7135 3 - - HYPH cord-010119-t1x9gknd 7135 4 old old JJ cord-010119-t1x9gknd 7135 5 Caucasian caucasian JJ cord-010119-t1x9gknd 7135 6 female female NN cord-010119-t1x9gknd 7135 7 was be VBD cord-010119-t1x9gknd 7135 8 referred refer VBN cord-010119-t1x9gknd 7135 9 to to IN cord-010119-t1x9gknd 7135 10 our -PRON- PRP$ cord-010119-t1x9gknd 7135 11 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 7135 12 Reference Reference NNP cord-010119-t1x9gknd 7135 13 Laboratory Laboratory NNP cord-010119-t1x9gknd 7135 14 ( ( -LRB- cord-010119-t1x9gknd 7135 15 IRL IRL NNP cord-010119-t1x9gknd 7135 16 ) ) -RRB- cord-010119-t1x9gknd 7135 17 for for IN cord-010119-t1x9gknd 7135 18 serological serological JJ cord-010119-t1x9gknd 7135 19 investigation investigation NN cord-010119-t1x9gknd 7135 20 . . . cord-010119-t1x9gknd 7136 1 She -PRON- PRP cord-010119-t1x9gknd 7136 2 was be VBD cord-010119-t1x9gknd 7136 3 diagnosed diagnose VBN cord-010119-t1x9gknd 7136 4 with with IN cord-010119-t1x9gknd 7136 5 anemia anemia NN cord-010119-t1x9gknd 7136 6 , , , cord-010119-t1x9gknd 7136 7 renal renal JJ cord-010119-t1x9gknd 7136 8 failure failure NN cord-010119-t1x9gknd 7136 9 and and CC cord-010119-t1x9gknd 7136 10 cardiac cardiac JJ cord-010119-t1x9gknd 7136 11 history history NN cord-010119-t1x9gknd 7136 12 . . . cord-010119-t1x9gknd 7137 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7137 2 hemoglobin hemoglobin NN cord-010119-t1x9gknd 7137 3 level level NN cord-010119-t1x9gknd 7137 4 was be VBD cord-010119-t1x9gknd 7137 5 recorded record VBN cord-010119-t1x9gknd 7137 6 at at IN cord-010119-t1x9gknd 7137 7 81g/ 81g/ CD cord-010119-t1x9gknd 7138 1 L. L. NNP cord-010119-t1x9gknd 7139 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7139 2 pregnancy pregnancy NN cord-010119-t1x9gknd 7139 3 history history NN cord-010119-t1x9gknd 7139 4 was be VBD cord-010119-t1x9gknd 7139 5 not not RB cord-010119-t1x9gknd 7139 6 provided provide VBN cord-010119-t1x9gknd 7139 7 . . . cord-010119-t1x9gknd 7140 1 She -PRON- PRP cord-010119-t1x9gknd 7140 2 had have VBD cord-010119-t1x9gknd 7140 3 received receive VBN cord-010119-t1x9gknd 7140 4 5 5 CD cord-010119-t1x9gknd 7140 5 units unit NNS cord-010119-t1x9gknd 7140 6 of of IN cord-010119-t1x9gknd 7140 7 packed packed JJ cord-010119-t1x9gknd 7140 8 red red JJ cord-010119-t1x9gknd 7140 9 blood blood NN cord-010119-t1x9gknd 7140 10 cells cell NNS cord-010119-t1x9gknd 7140 11 ( ( -LRB- cord-010119-t1x9gknd 7140 12 RBCs rbc NNS cord-010119-t1x9gknd 7140 13 ) ) -RRB- cord-010119-t1x9gknd 7140 14 in in IN cord-010119-t1x9gknd 7140 15 the the DT cord-010119-t1x9gknd 7140 16 past past NN cord-010119-t1x9gknd 7140 17 including include VBG cord-010119-t1x9gknd 7140 18 1 1 CD cord-010119-t1x9gknd 7140 19 unit unit NN cord-010119-t1x9gknd 7140 20 within within IN cord-010119-t1x9gknd 7140 21 the the DT cord-010119-t1x9gknd 7140 22 last last JJ cord-010119-t1x9gknd 7140 23 3 3 CD cord-010119-t1x9gknd 7140 24 months month NNS cord-010119-t1x9gknd 7140 25 . . . cord-010119-t1x9gknd 7141 1 None none NN cord-010119-t1x9gknd 7141 2 of of IN cord-010119-t1x9gknd 7141 3 the the DT cord-010119-t1x9gknd 7141 4 transfused transfuse VBN cord-010119-t1x9gknd 7141 5 unit unit NN cord-010119-t1x9gknd 7141 6 was be VBD cord-010119-t1x9gknd 7141 7 phenotypically phenotypically RB cord-010119-t1x9gknd 7141 8 - - HYPH cord-010119-t1x9gknd 7141 9 matched match VBN cord-010119-t1x9gknd 7141 10 . . . cord-010119-t1x9gknd 7142 1 The the DT cord-010119-t1x9gknd 7142 2 referring refer VBG cord-010119-t1x9gknd 7142 3 hospital hospital NN cord-010119-t1x9gknd 7142 4 obtained obtain VBD cord-010119-t1x9gknd 7142 5 panreactivity panreactivity NN cord-010119-t1x9gknd 7142 6 in in IN cord-010119-t1x9gknd 7142 7 gel gel NN cord-010119-t1x9gknd 7142 8 with with IN cord-010119-t1x9gknd 7142 9 LISS LISS NNP cord-010119-t1x9gknd 7142 10 - - HYPH cord-010119-t1x9gknd 7142 11 suspended suspend VBN cord-010119-t1x9gknd 7142 12 RBCs rbc NNS cord-010119-t1x9gknd 7142 13 and and CC cord-010119-t1x9gknd 7142 14 ficin ficin NNS cord-010119-t1x9gknd 7142 15 - - HYPH cord-010119-t1x9gknd 7142 16 treated treat VBN cord-010119-t1x9gknd 7142 17 RBCs rbc NNS cord-010119-t1x9gknd 7142 18 and and CC cord-010119-t1x9gknd 7142 19 negative negative JJ cord-010119-t1x9gknd 7142 20 direct direct JJ cord-010119-t1x9gknd 7142 21 antiglobulin antiglobulin NN cord-010119-t1x9gknd 7142 22 test test NN cord-010119-t1x9gknd 7142 23 ( ( -LRB- cord-010119-t1x9gknd 7142 24 DAT DAT NNP cord-010119-t1x9gknd 7142 25 ) ) -RRB- cord-010119-t1x9gknd 7142 26 and and CC cord-010119-t1x9gknd 7142 27 autocontrol autocontrol NNP cord-010119-t1x9gknd 7142 28 ( ( -LRB- cord-010119-t1x9gknd 7142 29 AT at RB cord-010119-t1x9gknd 7142 30 ) ) -RRB- cord-010119-t1x9gknd 7142 31 . . . cord-010119-t1x9gknd 7143 1 Study Study NNP cord-010119-t1x9gknd 7143 2 Design Design NNP cord-010119-t1x9gknd 7143 3 / / SYM cord-010119-t1x9gknd 7143 4 Methods method NNS cord-010119-t1x9gknd 7143 5 : : : cord-010119-t1x9gknd 7144 1 ABO ABO NNP cord-010119-t1x9gknd 7144 2 / / SYM cord-010119-t1x9gknd 7144 3 Rh Rh NNP cord-010119-t1x9gknd 7144 4 , , , cord-010119-t1x9gknd 7144 5 DAT DAT NNP cord-010119-t1x9gknd 7144 6 and and CC cord-010119-t1x9gknd 7144 7 antibody antibody NN cord-010119-t1x9gknd 7144 8 identification identification NN cord-010119-t1x9gknd 7144 9 were be VBD cord-010119-t1x9gknd 7144 10 performed perform VBN cord-010119-t1x9gknd 7144 11 by by IN cord-010119-t1x9gknd 7144 12 H H NNP cord-010119-t1x9gknd 7144 13 ema ema NNP cord-010119-t1x9gknd 7144 14 - - HYPH cord-010119-t1x9gknd 7144 15 Qu Qu NNP cord-010119-t1x9gknd 7144 16 ebec ebec NNP cord-010119-t1x9gknd 7144 17 's 's POS cord-010119-t1x9gknd 7144 18 IRL IRL NNP cord-010119-t1x9gknd 7144 19 according accord VBG cord-010119-t1x9gknd 7144 20 to to IN cord-010119-t1x9gknd 7144 21 approved approve VBN cord-010119-t1x9gknd 7144 22 techniques technique NNS cord-010119-t1x9gknd 7144 23 . . . cord-010119-t1x9gknd 7145 1 In in IN cord-010119-t1x9gknd 7145 2 addition addition NN cord-010119-t1x9gknd 7145 3 to to IN cord-010119-t1x9gknd 7145 4 LISS LISS NNP cord-010119-t1x9gknd 7145 5 - - HYPH cord-010119-t1x9gknd 7145 6 suspended suspend VBN cord-010119-t1x9gknd 7145 7 RBCs rbc NNS cord-010119-t1x9gknd 7145 8 and and CC cord-010119-t1x9gknd 7145 9 papain papain NN cord-010119-t1x9gknd 7145 10 - - HYPH cord-010119-t1x9gknd 7145 11 treated treat VBN cord-010119-t1x9gknd 7145 12 RBCs rbc NNS cord-010119-t1x9gknd 7145 13 , , , cord-010119-t1x9gknd 7145 14 trypsin trypsin NN cord-010119-t1x9gknd 7145 15 - - HYPH cord-010119-t1x9gknd 7145 16 treated treat VBN cord-010119-t1x9gknd 7145 17 and and CC cord-010119-t1x9gknd 7145 18 chemical chemical NN cord-010119-t1x9gknd 7145 19 - - HYPH cord-010119-t1x9gknd 7145 20 treated treat VBN cord-010119-t1x9gknd 7145 21 reagent reagent NN cord-010119-t1x9gknd 7145 22 RBCs rbc NNS cord-010119-t1x9gknd 7145 23 such such JJ cord-010119-t1x9gknd 7145 24 as as IN cord-010119-t1x9gknd 7145 25 dithiothreitol dithiothreitol NNP cord-010119-t1x9gknd 7145 26 ( ( -LRB- cord-010119-t1x9gknd 7145 27 DTT DTT NNP cord-010119-t1x9gknd 7145 28 ) ) -RRB- cord-010119-t1x9gknd 7145 29 were be VBD cord-010119-t1x9gknd 7145 30 tested test VBN cord-010119-t1x9gknd 7145 31 . . . cord-010119-t1x9gknd 7146 1 Alloadsorption Alloadsorption NNP cord-010119-t1x9gknd 7146 2 were be VBD cord-010119-t1x9gknd 7146 3 done do VBN cord-010119-t1x9gknd 7146 4 using use VBG cord-010119-t1x9gknd 7146 5 papain papain NN cord-010119-t1x9gknd 7146 6 - - HYPH cord-010119-t1x9gknd 7146 7 treated treat VBN cord-010119-t1x9gknd 7146 8 allogeneic allogeneic IN cord-010119-t1x9gknd 7146 9 RBCs rbc NNS cord-010119-t1x9gknd 7146 10 ( ( -LRB- cord-010119-t1x9gknd 7146 11 R r NN cord-010119-t1x9gknd 7146 12 1 1 CD cord-010119-t1x9gknd 7146 13 R r NN cord-010119-t1x9gknd 7146 14 1 1 CD cord-010119-t1x9gknd 7146 15 , , , cord-010119-t1x9gknd 7147 1 R r NN cord-010119-t1x9gknd 7147 2 2 2 CD cord-010119-t1x9gknd 7147 3 R r NN cord-010119-t1x9gknd 7147 4 2 2 CD cord-010119-t1x9gknd 7147 5 , , , cord-010119-t1x9gknd 7147 6 rr rr NNP cord-010119-t1x9gknd 7147 7 ) ) -RRB- cord-010119-t1x9gknd 7147 8 . . . cord-010119-t1x9gknd 7148 1 ID ID NNP cord-010119-t1x9gknd 7148 2 CORE CORE NNP cord-010119-t1x9gknd 7148 3 XT XT NNP cord-010119-t1x9gknd 7148 4 platform platform NN cord-010119-t1x9gknd 7148 5 ( ( -LRB- cord-010119-t1x9gknd 7148 6 Progenika Progenika NNP cord-010119-t1x9gknd 7148 7 Biopharm Biopharm NNP cord-010119-t1x9gknd 7148 8 / / SYM cord-010119-t1x9gknd 7148 9 Grifols Grifols NNP cord-010119-t1x9gknd 7148 10 , , , cord-010119-t1x9gknd 7148 11 Vizcaya Vizcaya NNP cord-010119-t1x9gknd 7148 12 , , , cord-010119-t1x9gknd 7148 13 Spain Spain NNP cord-010119-t1x9gknd 7148 14 ) ) -RRB- cord-010119-t1x9gknd 7148 15 was be VBD cord-010119-t1x9gknd 7148 16 used use VBN cord-010119-t1x9gknd 7148 17 to to TO cord-010119-t1x9gknd 7148 18 analyse analyse VB cord-010119-t1x9gknd 7148 19 29 29 CD cord-010119-t1x9gknd 7148 20 polymorphisms polymorphism NNS cord-010119-t1x9gknd 7148 21 which which WDT cord-010119-t1x9gknd 7148 22 determine determine VBP cord-010119-t1x9gknd 7148 23 37 37 CD cord-010119-t1x9gknd 7148 24 antigens antigen NNS cord-010119-t1x9gknd 7148 25 including include VBG cord-010119-t1x9gknd 7148 26 Carthright Carthright NNP cord-010119-t1x9gknd 7148 27 and and CC cord-010119-t1x9gknd 7148 28 Lutheran Lutheran NNP cord-010119-t1x9gknd 7148 29 blood blood NN cord-010119-t1x9gknd 7148 30 groups group NNS cord-010119-t1x9gknd 7148 31 . . . cord-010119-t1x9gknd 7149 1 PCR PCR NNP cord-010119-t1x9gknd 7149 2 - - HYPH cord-010119-t1x9gknd 7149 3 SSP SSP NNP cord-010119-t1x9gknd 7149 4 ( ( -LRB- cord-010119-t1x9gknd 7149 5 Sequence Sequence NNP cord-010119-t1x9gknd 7149 6 Specific Specific NNP cord-010119-t1x9gknd 7149 7 Primer Primer NNP cord-010119-t1x9gknd 7149 8 ) ) -RRB- cord-010119-t1x9gknd 7149 9 and and CC cord-010119-t1x9gknd 7149 10 PCR PCR NNP cord-010119-t1x9gknd 7149 11 - - HYPH cord-010119-t1x9gknd 7149 12 RFLP RFLP NNP cord-010119-t1x9gknd 7150 1 ( ( -LRB- cord-010119-t1x9gknd 7150 2 Restriction restriction NN cord-010119-t1x9gknd 7150 3 Fragment Fragment NNP cord-010119-t1x9gknd 7150 4 Length length NN cord-010119-t1x9gknd 7150 5 Polymorphism Polymorphism NNP cord-010119-t1x9gknd 7150 6 ) ) -RRB- cord-010119-t1x9gknd 7150 7 were be VBD cord-010119-t1x9gknd 7150 8 also also RB cord-010119-t1x9gknd 7150 9 performed perform VBN cord-010119-t1x9gknd 7150 10 to to TO cord-010119-t1x9gknd 7150 11 verify verify VB cord-010119-t1x9gknd 7150 12 the the DT cord-010119-t1x9gknd 7150 13 absence absence NN cord-010119-t1x9gknd 7150 14 of of IN cord-010119-t1x9gknd 7150 15 the the DT cord-010119-t1x9gknd 7150 16 high high JJ cord-010119-t1x9gknd 7150 17 frequency frequency NN cord-010119-t1x9gknd 7150 18 antigens antigen NNS cord-010119-t1x9gknd 7150 19 Yt Yt NNP cord-010119-t1x9gknd 7150 20 a a NNP cord-010119-t1x9gknd 7150 21 and and CC cord-010119-t1x9gknd 7150 22 Lu Lu NNP cord-010119-t1x9gknd 7150 23 b b NNP cord-010119-t1x9gknd 7150 24 . . . cord-010119-t1x9gknd 7151 1 Sibling sibling NN cord-010119-t1x9gknd 7151 2 samples sample NNS cord-010119-t1x9gknd 7151 3 were be VBD cord-010119-t1x9gknd 7151 4 also also RB cord-010119-t1x9gknd 7151 5 requested request VBN cord-010119-t1x9gknd 7151 6 to to TO cord-010119-t1x9gknd 7151 7 conduct conduct VB cord-010119-t1x9gknd 7151 8 a a DT cord-010119-t1x9gknd 7151 9 family family NN cord-010119-t1x9gknd 7151 10 study study NN cord-010119-t1x9gknd 7151 11 . . . cord-010119-t1x9gknd 7152 1 Results result NNS cord-010119-t1x9gknd 7152 2 / / SYM cord-010119-t1x9gknd 7152 3 Findings finding NNS cord-010119-t1x9gknd 7152 4 : : : cord-010119-t1x9gknd 7153 1 Initial initial JJ cord-010119-t1x9gknd 7153 2 serologic serologic NN cord-010119-t1x9gknd 7153 3 testing testing NN cord-010119-t1x9gknd 7153 4 showed show VBD cord-010119-t1x9gknd 7153 5 strongly strongly RB cord-010119-t1x9gknd 7153 6 reactive reactive JJ cord-010119-t1x9gknd 7153 7 panels panel NNS cord-010119-t1x9gknd 7153 8 in in IN cord-010119-t1x9gknd 7153 9 gel gel NN cord-010119-t1x9gknd 7153 10 with with IN cord-010119-t1x9gknd 7153 11 LISS LISS NNP cord-010119-t1x9gknd 7153 12 suspended suspend VBN cord-010119-t1x9gknd 7153 13 RBCs rbc NNS cord-010119-t1x9gknd 7153 14 , , , cord-010119-t1x9gknd 7153 15 papain papain NN cord-010119-t1x9gknd 7153 16 - - HYPH cord-010119-t1x9gknd 7153 17 treated treat VBN cord-010119-t1x9gknd 7153 18 RBCs rbc NNS cord-010119-t1x9gknd 7153 19 as as RB cord-010119-t1x9gknd 7153 20 well well RB cord-010119-t1x9gknd 7153 21 as as IN cord-010119-t1x9gknd 7153 22 trypsintreated trypsintreated JJ cord-010119-t1x9gknd 7153 23 RBCs rbc NNS cord-010119-t1x9gknd 7153 24 and and CC cord-010119-t1x9gknd 7153 25 DTT DTT NNP cord-010119-t1x9gknd 7153 26 - - HYPH cord-010119-t1x9gknd 7153 27 treated treat VBN cord-010119-t1x9gknd 7153 28 RBCs rbc NNS cord-010119-t1x9gknd 7153 29 but but CC cord-010119-t1x9gknd 7154 1 negative negative JJ cord-010119-t1x9gknd 7154 2 AT at IN cord-010119-t1x9gknd 7154 3 in in IN cord-010119-t1x9gknd 7154 4 each each DT cord-010119-t1x9gknd 7154 5 media medium NNS cord-010119-t1x9gknd 7154 6 leading lead VBG cord-010119-t1x9gknd 7154 7 to to IN cord-010119-t1x9gknd 7154 8 a a DT cord-010119-t1x9gknd 7154 9 probable probable JJ cord-010119-t1x9gknd 7154 10 antibody antibody NN cord-010119-t1x9gknd 7154 11 directed direct VBN cord-010119-t1x9gknd 7154 12 against against IN cord-010119-t1x9gknd 7154 13 high high JJ cord-010119-t1x9gknd 7154 14 - - HYPH cord-010119-t1x9gknd 7154 15 frequency frequency NN cord-010119-t1x9gknd 7154 16 antigen antigen NN cord-010119-t1x9gknd 7154 17 . . . cord-010119-t1x9gknd 7155 1 Alloadsorption alloadsorption NN cord-010119-t1x9gknd 7155 2 procedure procedure NN cord-010119-t1x9gknd 7155 3 allowed allow VBD cord-010119-t1x9gknd 7155 4 the the DT cord-010119-t1x9gknd 7155 5 identification identification NN cord-010119-t1x9gknd 7155 6 of of IN cord-010119-t1x9gknd 7155 7 an an DT cord-010119-t1x9gknd 7155 8 anti anti JJ cord-010119-t1x9gknd 7155 9 - - JJ cord-010119-t1x9gknd 7155 10 Jk Jk NNP cord-010119-t1x9gknd 7155 11 a a DT cord-010119-t1x9gknd 7155 12 . . . cord-010119-t1x9gknd 7156 1 A a DT cord-010119-t1x9gknd 7156 2 select select JJ cord-010119-t1x9gknd 7156 3 panel panel NN cord-010119-t1x9gknd 7156 4 of of IN cord-010119-t1x9gknd 7156 5 high high JJ cord-010119-t1x9gknd 7156 6 frequency frequency NN cord-010119-t1x9gknd 7156 7 antigens antigen NNS cord-010119-t1x9gknd 7156 8 absent absent JJ cord-010119-t1x9gknd 7156 9 in in IN cord-010119-t1x9gknd 7156 10 Caucasian caucasian JJ cord-010119-t1x9gknd 7156 11 population population NN cord-010119-t1x9gknd 7156 12 was be VBD cord-010119-t1x9gknd 7156 13 tested test VBN cord-010119-t1x9gknd 7156 14 . . . cord-010119-t1x9gknd 7157 1 The the DT cord-010119-t1x9gknd 7157 2 patient patient NN cord-010119-t1x9gknd 7157 3 's 's POS cord-010119-t1x9gknd 7157 4 sera sera NNP cord-010119-t1x9gknd 7157 5 react react VB cord-010119-t1x9gknd 7157 6 weakly weakly RB cord-010119-t1x9gknd 7157 7 with with IN cord-010119-t1x9gknd 7157 8 one one CD cord-010119-t1x9gknd 7157 9 Jk(a- jk(a- CD cord-010119-t1x9gknd 7157 10 ) ) -RRB- cord-010119-t1x9gknd 7157 11 , , , cord-010119-t1x9gknd 7157 12 Lu(a Lu(a NNP cord-010119-t1x9gknd 7157 13 - - HYPH cord-010119-t1x9gknd 7157 14 b- b- NNP cord-010119-t1x9gknd 7157 15 ) ) -RRB- cord-010119-t1x9gknd 7157 16 reagent reagent JJ cord-010119-t1x9gknd 7157 17 cell cell NN cord-010119-t1x9gknd 7157 18 . . . cord-010119-t1x9gknd 7158 1 In in IN cord-010119-t1x9gknd 7158 2 the the DT cord-010119-t1x9gknd 7158 3 meantime meantime NN cord-010119-t1x9gknd 7158 4 , , , cord-010119-t1x9gknd 7158 5 genotyping genotyping NN cord-010119-t1x9gknd 7158 6 results result NNS cord-010119-t1x9gknd 7158 7 confirm confirm VBP cord-010119-t1x9gknd 7158 8 the the DT cord-010119-t1x9gknd 7158 9 probable probable JJ cord-010119-t1x9gknd 7158 10 phenotype phenotype NN cord-010119-t1x9gknd 7158 11 of of IN cord-010119-t1x9gknd 7158 12 the the DT cord-010119-t1x9gknd 7158 13 patient patient NN cord-010119-t1x9gknd 7158 14 as as IN cord-010119-t1x9gknd 7158 15 Jk(a- jk(a- CD cord-010119-t1x9gknd 7158 16 ) ) -RRB- cord-010119-t1x9gknd 7158 17 Lu(b- Lu(b- NNS cord-010119-t1x9gknd 7158 18 ) ) -RRB- cord-010119-t1x9gknd 7158 19 Yt(a- yt(a- CD cord-010119-t1x9gknd 7158 20 ) ) -RRB- cord-010119-t1x9gknd 7158 21 . . . cord-010119-t1x9gknd 7159 1 Additional additional JJ cord-010119-t1x9gknd 7159 2 testing testing NN cord-010119-t1x9gknd 7159 3 in in IN cord-010119-t1x9gknd 7159 4 gel gel NN cord-010119-t1x9gknd 7159 5 using use VBG cord-010119-t1x9gknd 7159 6 Trypsin Trypsin NNP cord-010119-t1x9gknd 7159 7 and and CC cord-010119-t1x9gknd 7159 8 DTT DTT NNP cord-010119-t1x9gknd 7159 9 differential differential JJ cord-010119-t1x9gknd 7159 10 effects effect NNS cord-010119-t1x9gknd 7159 11 on on IN cord-010119-t1x9gknd 7159 12 antigens antigen NNS cord-010119-t1x9gknd 7159 13 Lu(b Lu(b NNP cord-010119-t1x9gknd 7159 14 ) ) -RRB- cord-010119-t1x9gknd 7159 15 and and CC cord-010119-t1x9gknd 7159 16 Yt(a Yt(a NNP cord-010119-t1x9gknd 7159 17 ) ) -RRB- cord-010119-t1x9gknd 7159 18 were be VBD cord-010119-t1x9gknd 7159 19 performed perform VBN cord-010119-t1x9gknd 7159 20 to to TO cord-010119-t1x9gknd 7159 21 confirm confirm VB cord-010119-t1x9gknd 7159 22 antibody antibody NN cord-010119-t1x9gknd 7159 23 specificities specificity NNS cord-010119-t1x9gknd 7159 24 . . . cord-010119-t1x9gknd 7160 1 No no DT cord-010119-t1x9gknd 7160 2 RBCs RBCs NNPS cord-010119-t1x9gknd 7160 3 unit unit NN cord-010119-t1x9gknd 7160 4 Jk(a- jk(a- CD cord-010119-t1x9gknd 7160 5 ) ) -RRB- cord-010119-t1x9gknd 7160 6 Lu(b- Lu(b- NNS cord-010119-t1x9gknd 7160 7 ) ) -RRB- cord-010119-t1x9gknd 7160 8 Yt(a- Yt(a- NFP cord-010119-t1x9gknd 7160 9 ) ) -RRB- cord-010119-t1x9gknd 7160 10 were be VBD cord-010119-t1x9gknd 7160 11 available available JJ cord-010119-t1x9gknd 7160 12 for for IN cord-010119-t1x9gknd 7160 13 transfusion transfusion NN cord-010119-t1x9gknd 7160 14 . . . cord-010119-t1x9gknd 7161 1 Selected select VBN cord-010119-t1x9gknd 7161 2 units unit NNS cord-010119-t1x9gknd 7161 3 were be VBD cord-010119-t1x9gknd 7161 4 Jk(a- jk(a- CD cord-010119-t1x9gknd 7161 5 ) ) -RRB- cord-010119-t1x9gknd 7161 6 and and CC cord-010119-t1x9gknd 7161 7 Lu(b- lu(b- CD cord-010119-t1x9gknd 7161 8 ) ) -RRB- cord-010119-t1x9gknd 7161 9 as as IN cord-010119-t1x9gknd 7161 10 alloanti alloanti NNP cord-010119-t1x9gknd 7161 11 - - HYPH cord-010119-t1x9gknd 7161 12 Yt Yt NNP cord-010119-t1x9gknd 7161 13 a a DT cord-010119-t1x9gknd 7161 14 are be VBP cord-010119-t1x9gknd 7161 15 known know VBN cord-010119-t1x9gknd 7161 16 to to TO cord-010119-t1x9gknd 7161 17 cause cause VB cord-010119-t1x9gknd 7161 18 none none NN cord-010119-t1x9gknd 7161 19 to to TO cord-010119-t1x9gknd 7161 20 moderate moderate JJ cord-010119-t1x9gknd 7161 21 transfusion transfusion NN cord-010119-t1x9gknd 7161 22 reactions reaction NNS cord-010119-t1x9gknd 7161 23 . . . cord-010119-t1x9gknd 7162 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7162 2 daughter daughter NN cord-010119-t1x9gknd 7162 3 ' ' POS cord-010119-t1x9gknd 7162 4 sample sample NN cord-010119-t1x9gknd 7162 5 were be VBD cord-010119-t1x9gknd 7162 6 types type NNS cord-010119-t1x9gknd 7162 7 as as IN cord-010119-t1x9gknd 7162 8 Yt(a1 Yt(a1 NNP cord-010119-t1x9gknd 7162 9 ) ) -RRB- cord-010119-t1x9gknd 7162 10 and and CC cord-010119-t1x9gknd 7162 11 Lu(b1 Lu(b1 NNP cord-010119-t1x9gknd 7162 12 ) ) -RRB- cord-010119-t1x9gknd 7162 13 . . . cord-010119-t1x9gknd 7163 1 Conclusion conclusion NN cord-010119-t1x9gknd 7163 2 : : : cord-010119-t1x9gknd 7164 1 Serological serological JJ cord-010119-t1x9gknd 7164 2 study study NN cord-010119-t1x9gknd 7164 3 showed show VBD cord-010119-t1x9gknd 7164 4 the the DT cord-010119-t1x9gknd 7164 5 presence presence NN cord-010119-t1x9gknd 7164 6 of of IN cord-010119-t1x9gknd 7164 7 an an DT cord-010119-t1x9gknd 7164 8 anti anti JJ cord-010119-t1x9gknd 7164 9 - - JJ cord-010119-t1x9gknd 7164 10 Jk Jk NNP cord-010119-t1x9gknd 7164 11 a a DT cord-010119-t1x9gknd 7164 12 in in IN cord-010119-t1x9gknd 7164 13 addition addition NN cord-010119-t1x9gknd 7164 14 to to IN cord-010119-t1x9gknd 7164 15 two two CD cord-010119-t1x9gknd 7164 16 antibodies antibody NNS cord-010119-t1x9gknd 7164 17 directed direct VBN cord-010119-t1x9gknd 7164 18 against against IN cord-010119-t1x9gknd 7164 19 high high JJ cord-010119-t1x9gknd 7164 20 prevalence prevalence NN cord-010119-t1x9gknd 7164 21 antigen antigen NN cord-010119-t1x9gknd 7164 22 namely namely RB cord-010119-t1x9gknd 7164 23 anti anti NNP cord-010119-t1x9gknd 7164 24 - - NNP cord-010119-t1x9gknd 7164 25 Lu Lu NNP cord-010119-t1x9gknd 7164 26 b b NNP cord-010119-t1x9gknd 7164 27 and and CC cord-010119-t1x9gknd 7164 28 anti anti NNP cord-010119-t1x9gknd 7164 29 - - NNP cord-010119-t1x9gknd 7164 30 Yt Yt NNP cord-010119-t1x9gknd 7164 31 a a NN cord-010119-t1x9gknd 7164 32 . . . cord-010119-t1x9gknd 7165 1 The the DT cord-010119-t1x9gknd 7165 2 association association NN cord-010119-t1x9gknd 7165 3 of of IN cord-010119-t1x9gknd 7165 4 various various JJ cord-010119-t1x9gknd 7165 5 selected select VBN cord-010119-t1x9gknd 7165 6 serologic serologic JJ cord-010119-t1x9gknd 7165 7 procedures procedure NNS cord-010119-t1x9gknd 7165 8 combined combine VBN cord-010119-t1x9gknd 7165 9 with with IN cord-010119-t1x9gknd 7165 10 ethnic ethnic JJ cord-010119-t1x9gknd 7165 11 clues clue NNS cord-010119-t1x9gknd 7165 12 and and CC cord-010119-t1x9gknd 7165 13 genotyping genotyping NN cord-010119-t1x9gknd 7165 14 results result NNS cord-010119-t1x9gknd 7165 15 serves serve VBZ cord-010119-t1x9gknd 7165 16 to to TO cord-010119-t1x9gknd 7165 17 solve solve VB cord-010119-t1x9gknd 7165 18 this this DT cord-010119-t1x9gknd 7165 19 uncommon uncommon JJ cord-010119-t1x9gknd 7165 20 antibody antibody NN cord-010119-t1x9gknd 7165 21 combination combination NN cord-010119-t1x9gknd 7165 22 . . . cord-010119-t1x9gknd 7166 1 Background Background NNP cord-010119-t1x9gknd 7166 2 / / SYM cord-010119-t1x9gknd 7166 3 Case Case NNP cord-010119-t1x9gknd 7166 4 Studies Studies NNPS cord-010119-t1x9gknd 7166 5 : : : cord-010119-t1x9gknd 7167 1 The the DT cord-010119-t1x9gknd 7167 2 KEL KEL NNP cord-010119-t1x9gknd 7167 3 blood blood NN cord-010119-t1x9gknd 7167 4 group group NN cord-010119-t1x9gknd 7167 5 system system NN cord-010119-t1x9gknd 7167 6 , , , cord-010119-t1x9gknd 7167 7 consisting consist VBG cord-010119-t1x9gknd 7167 8 of of IN cord-010119-t1x9gknd 7167 9 36 36 CD cord-010119-t1x9gknd 7167 10 antigens antigen NNS cord-010119-t1x9gknd 7167 11 encoded encode VBN cord-010119-t1x9gknd 7167 12 by by IN cord-010119-t1x9gknd 7167 13 the the DT cord-010119-t1x9gknd 7167 14 KEL KEL NNP cord-010119-t1x9gknd 7167 15 gene gene NN cord-010119-t1x9gknd 7167 16 , , , cord-010119-t1x9gknd 7167 17 is be VBZ cord-010119-t1x9gknd 7167 18 organized organize VBN cord-010119-t1x9gknd 7167 19 into into IN cord-010119-t1x9gknd 7167 20 19 19 CD cord-010119-t1x9gknd 7167 21 exons exon NNS cord-010119-t1x9gknd 7167 22 . . . cord-010119-t1x9gknd 7168 1 There there EX cord-010119-t1x9gknd 7168 2 are be VBP cord-010119-t1x9gknd 7168 3 approximately approximately RB cord-010119-t1x9gknd 7168 4 30 30 CD cord-010119-t1x9gknd 7168 5 KEL KEL NNP cord-010119-t1x9gknd 7168 6 alleles allele NNS cord-010119-t1x9gknd 7168 7 associated associate VBN cord-010119-t1x9gknd 7168 8 with with IN cord-010119-t1x9gknd 7168 9 a a DT cord-010119-t1x9gknd 7168 10 Kell Kell NNP cord-010119-t1x9gknd 7168 11 null null JJ cord-010119-t1x9gknd 7168 12 phenotype phenotype NN cord-010119-t1x9gknd 7168 13 ( ( -LRB- cord-010119-t1x9gknd 7168 14 K k NN cord-010119-t1x9gknd 7168 15 0 0 CD cord-010119-t1x9gknd 7168 16 ) ) -RRB- cord-010119-t1x9gknd 7168 17 in in IN cord-010119-t1x9gknd 7168 18 which which WDT cord-010119-t1x9gknd 7168 19 no no DT cord-010119-t1x9gknd 7168 20 Kell Kell NNP cord-010119-t1x9gknd 7168 21 antigens antigen NNS cord-010119-t1x9gknd 7168 22 are be VBP cord-010119-t1x9gknd 7168 23 expressed express VBN cord-010119-t1x9gknd 7168 24 , , , cord-010119-t1x9gknd 7168 25 and and CC cord-010119-t1x9gknd 7168 26 12 12 CD cord-010119-t1x9gknd 7168 27 alleles allele NNS cord-010119-t1x9gknd 7168 28 associated associate VBN cord-010119-t1x9gknd 7168 29 with with IN cord-010119-t1x9gknd 7168 30 a a DT cord-010119-t1x9gknd 7168 31 Kell Kell NNP cord-010119-t1x9gknd 7168 32 mod mod NN cord-010119-t1x9gknd 7168 33 phenotype phenotype NN cord-010119-t1x9gknd 7168 34 ( ( -LRB- cord-010119-t1x9gknd 7168 35 K k NN cord-010119-t1x9gknd 7168 36 mod mod NN cord-010119-t1x9gknd 7168 37 ) ) -RRB- cord-010119-t1x9gknd 7168 38 . . . cord-010119-t1x9gknd 7169 1 Individuals individual NNS cord-010119-t1x9gknd 7169 2 with with IN cord-010119-t1x9gknd 7169 3 the the DT cord-010119-t1x9gknd 7169 4 K k NN cord-010119-t1x9gknd 7169 5 mod mod NN cord-010119-t1x9gknd 7169 6 phenotype phenotype NN cord-010119-t1x9gknd 7169 7 express express VB cord-010119-t1x9gknd 7169 8 very very RB cord-010119-t1x9gknd 7169 9 weak weak JJ cord-010119-t1x9gknd 7169 10 amounts amount NNS cord-010119-t1x9gknd 7169 11 of of IN cord-010119-t1x9gknd 7169 12 antigen antigen NN cord-010119-t1x9gknd 7169 13 on on IN cord-010119-t1x9gknd 7169 14 the the DT cord-010119-t1x9gknd 7169 15 surface surface NN cord-010119-t1x9gknd 7169 16 of of IN cord-010119-t1x9gknd 7169 17 the the DT cord-010119-t1x9gknd 7169 18 RBC RBC NNP cord-010119-t1x9gknd 7169 19 , , , cord-010119-t1x9gknd 7169 20 and and CC cord-010119-t1x9gknd 7169 21 expression expression NN cord-010119-t1x9gknd 7169 22 levels level NNS cord-010119-t1x9gknd 7169 23 vary vary VBP cord-010119-t1x9gknd 7169 24 based base VBN cord-010119-t1x9gknd 7169 25 on on IN cord-010119-t1x9gknd 7169 26 the the DT cord-010119-t1x9gknd 7169 27 allele allele NN cord-010119-t1x9gknd 7169 28 present present NN cord-010119-t1x9gknd 7169 29 . . . cord-010119-t1x9gknd 7170 1 Here here RB cord-010119-t1x9gknd 7170 2 we -PRON- PRP cord-010119-t1x9gknd 7170 3 describe describe VBP cord-010119-t1x9gknd 7170 4 the the DT cord-010119-t1x9gknd 7170 5 molecular molecular JJ cord-010119-t1x9gknd 7170 6 and and CC cord-010119-t1x9gknd 7170 7 serologic serologic NN cord-010119-t1x9gknd 7170 8 testing testing NN cord-010119-t1x9gknd 7170 9 that that WDT cord-010119-t1x9gknd 7170 10 was be VBD cord-010119-t1x9gknd 7170 11 performed perform VBN cord-010119-t1x9gknd 7170 12 in in IN cord-010119-t1x9gknd 7170 13 the the DT cord-010119-t1x9gknd 7170 14 case case NN cord-010119-t1x9gknd 7170 15 of of IN cord-010119-t1x9gknd 7170 16 a a DT cord-010119-t1x9gknd 7170 17 53 53 CD cord-010119-t1x9gknd 7170 18 year year NN cord-010119-t1x9gknd 7170 19 - - HYPH cord-010119-t1x9gknd 7170 20 old old JJ cord-010119-t1x9gknd 7170 21 Hispanic hispanic JJ cord-010119-t1x9gknd 7170 22 male male JJ cord-010119-t1x9gknd 7170 23 blood blood NN cord-010119-t1x9gknd 7170 24 donor donor NN cord-010119-t1x9gknd 7170 25 whose whose WP$ cord-010119-t1x9gknd 7170 26 RBCs rbc NNS cord-010119-t1x9gknd 7170 27 phenotyped phenotype VBD cord-010119-t1x9gknd 7170 28 K K NNP cord-010119-t1x9gknd 7170 29 - - HYPH cord-010119-t1x9gknd 7170 30 k k NNP cord-010119-t1x9gknd 7170 31 - - HYPH cord-010119-t1x9gknd 7170 32 Js(b- Js(b- NNP cord-010119-t1x9gknd 7170 33 ) ) -RRB- cord-010119-t1x9gknd 7170 34 Kp(b- kp(b- CD cord-010119-t1x9gknd 7170 35 ) ) -RRB- cord-010119-t1x9gknd 7170 36 . . . cord-010119-t1x9gknd 7171 1 Study Study NNP cord-010119-t1x9gknd 7171 2 Design Design NNP cord-010119-t1x9gknd 7171 3 / / SYM cord-010119-t1x9gknd 7171 4 Method method NN cord-010119-t1x9gknd 7171 5 : : : cord-010119-t1x9gknd 7171 6 The the DT cord-010119-t1x9gknd 7171 7 blood blood NN cord-010119-t1x9gknd 7171 8 donor donor NN cord-010119-t1x9gknd 7171 9 was be VBD cord-010119-t1x9gknd 7171 10 phenotyped phenotype VBN cord-010119-t1x9gknd 7171 11 for for IN cord-010119-t1x9gknd 7171 12 K K NNP cord-010119-t1x9gknd 7171 13 , , , cord-010119-t1x9gknd 7171 14 k k NNP cord-010119-t1x9gknd 7171 15 , , , cord-010119-t1x9gknd 7171 16 Kp Kp NNP cord-010119-t1x9gknd 7171 17 b b NNP cord-010119-t1x9gknd 7171 18 and and CC cord-010119-t1x9gknd 7171 19 Js Js NNP cord-010119-t1x9gknd 7171 20 b b NNP cord-010119-t1x9gknd 7171 21 antigens antigen NNS cord-010119-t1x9gknd 7171 22 using use VBG cord-010119-t1x9gknd 7171 23 standard standard JJ cord-010119-t1x9gknd 7171 24 tube tube NN cord-010119-t1x9gknd 7171 25 agglutination agglutination NN cord-010119-t1x9gknd 7171 26 methods method NNS cord-010119-t1x9gknd 7171 27 . . . cord-010119-t1x9gknd 7172 1 Adsorption Adsorption NNP cord-010119-t1x9gknd 7172 2 and and CC cord-010119-t1x9gknd 7172 3 elution elution NN cord-010119-t1x9gknd 7172 4 studies study NNS cord-010119-t1x9gknd 7172 5 of of IN cord-010119-t1x9gknd 7172 6 the the DT cord-010119-t1x9gknd 7172 7 donor donor NN cord-010119-t1x9gknd 7172 8 red red JJ cord-010119-t1x9gknd 7172 9 cells cell NNS cord-010119-t1x9gknd 7172 10 were be VBD cord-010119-t1x9gknd 7172 11 performed perform VBN cord-010119-t1x9gknd 7172 12 using use VBG cord-010119-t1x9gknd 7172 13 commercial commercial JJ cord-010119-t1x9gknd 7172 14 anti anti JJ cord-010119-t1x9gknd 7172 15 - - JJ cord-010119-t1x9gknd 7172 16 k k NNP cord-010119-t1x9gknd 7172 17 antisera antisera NNP cord-010119-t1x9gknd 7172 18 ( ( -LRB- cord-010119-t1x9gknd 7172 19 American American NNP cord-010119-t1x9gknd 7172 20 National National NNP cord-010119-t1x9gknd 7172 21 Red Red NNP cord-010119-t1x9gknd 7172 22 Cross Cross NNP cord-010119-t1x9gknd 7172 23 ) ) -RRB- cord-010119-t1x9gknd 7172 24 . . . cord-010119-t1x9gknd 7173 1 Genomic genomic JJ cord-010119-t1x9gknd 7173 2 DNA dna NN cord-010119-t1x9gknd 7173 3 ( ( -LRB- cord-010119-t1x9gknd 7173 4 gDNA gdna NN cord-010119-t1x9gknd 7173 5 ) ) -RRB- cord-010119-t1x9gknd 7173 6 was be VBD cord-010119-t1x9gknd 7173 7 isolated isolate VBN cord-010119-t1x9gknd 7173 8 from from IN cord-010119-t1x9gknd 7173 9 an an DT cord-010119-t1x9gknd 7173 10 EDTA EDTA NNP cord-010119-t1x9gknd 7173 11 blood blood NN cord-010119-t1x9gknd 7173 12 tube tube NN cord-010119-t1x9gknd 7173 13 using use VBG cord-010119-t1x9gknd 7173 14 standard standard JJ cord-010119-t1x9gknd 7173 15 techniques technique NNS cord-010119-t1x9gknd 7173 16 . . . cord-010119-t1x9gknd 7174 1 DNA DNA NNP cord-010119-t1x9gknd 7174 2 was be VBD cord-010119-t1x9gknd 7174 3 genotyped genotype VBN cord-010119-t1x9gknd 7174 4 for for IN cord-010119-t1x9gknd 7174 5 human human JJ cord-010119-t1x9gknd 7174 6 erythrocyte erythrocyte NN cord-010119-t1x9gknd 7174 7 antigens antigen NNS cord-010119-t1x9gknd 7174 8 using use VBG cord-010119-t1x9gknd 7174 9 the the DT cord-010119-t1x9gknd 7174 10 PreciseType PreciseType NNP cord-010119-t1x9gknd 7174 11 TM TM NNP cord-010119-t1x9gknd 7174 12 HEA HEA NNP cord-010119-t1x9gknd 7174 13 Molecular Molecular NNP cord-010119-t1x9gknd 7174 14 BeadChip BeadChip NNP cord-010119-t1x9gknd 7174 15 ( ( -LRB- cord-010119-t1x9gknd 7174 16 Immucor Immucor NNP cord-010119-t1x9gknd 7174 17 ) ) -RRB- cord-010119-t1x9gknd 7174 18 . . . cord-010119-t1x9gknd 7175 1 Exons Exons NNP cord-010119-t1x9gknd 7175 2 10 10 CD cord-010119-t1x9gknd 7175 3 , , , cord-010119-t1x9gknd 7175 4 11 11 CD cord-010119-t1x9gknd 7175 5 , , , cord-010119-t1x9gknd 7175 6 12,13 12,13 CD cord-010119-t1x9gknd 7175 7 and and CC cord-010119-t1x9gknd 7175 8 14 14 CD cord-010119-t1x9gknd 7175 9 and and CC cord-010119-t1x9gknd 7175 10 flanking flanking JJ cord-010119-t1x9gknd 7175 11 intron intron NN cord-010119-t1x9gknd 7175 12 sequences sequence NNS cord-010119-t1x9gknd 7175 13 were be VBD cord-010119-t1x9gknd 7175 14 amplified amplify VBN cord-010119-t1x9gknd 7175 15 and and CC cord-010119-t1x9gknd 7175 16 sequenced sequence VBN cord-010119-t1x9gknd 7175 17 . . . cord-010119-t1x9gknd 7176 1 Total Total NNP cord-010119-t1x9gknd 7176 2 RNA RNA NNP cord-010119-t1x9gknd 7176 3 was be VBD cord-010119-t1x9gknd 7176 4 extracted extract VBN cord-010119-t1x9gknd 7176 5 using use VBG cord-010119-t1x9gknd 7176 6 RNeasy RNeasy NNP cord-010119-t1x9gknd 7176 7 Lipid Lipid NNP cord-010119-t1x9gknd 7176 8 Tissue Tissue NNP cord-010119-t1x9gknd 7176 9 Mini Mini NNP cord-010119-t1x9gknd 7176 10 kit kit NN cord-010119-t1x9gknd 7176 11 ( ( -LRB- cord-010119-t1x9gknd 7176 12 QIAGEN QIAGEN NNP cord-010119-t1x9gknd 7176 13 ) ) -RRB- cord-010119-t1x9gknd 7176 14 and and CC cord-010119-t1x9gknd 7176 15 KEL KEL NNP cord-010119-t1x9gknd 7176 16 cDNA cDNA NNP cord-010119-t1x9gknd 7176 17 was be VBD cord-010119-t1x9gknd 7176 18 amplified amplify VBN cord-010119-t1x9gknd 7176 19 and and CC cord-010119-t1x9gknd 7176 20 the the DT cord-010119-t1x9gknd 7176 21 resulting result VBG cord-010119-t1x9gknd 7176 22 PCR PCR NNP cord-010119-t1x9gknd 7176 23 product product NN cord-010119-t1x9gknd 7176 24 was be VBD cord-010119-t1x9gknd 7176 25 subjected subject VBN cord-010119-t1x9gknd 7176 26 to to IN cord-010119-t1x9gknd 7176 27 Sanger Sanger NNP cord-010119-t1x9gknd 7176 28 sequence sequence NN cord-010119-t1x9gknd 7176 29 analysis analysis NN cord-010119-t1x9gknd 7176 30 and and CC cord-010119-t1x9gknd 7176 31 aligned align VBN cord-010119-t1x9gknd 7176 32 using use VBG cord-010119-t1x9gknd 7176 33 Sequencher Sequencher NNP cord-010119-t1x9gknd 7176 34 ( ( -LRB- cord-010119-t1x9gknd 7176 35 GeneCodes GeneCodes NNP cord-010119-t1x9gknd 7176 36 ) ) -RRB- cord-010119-t1x9gknd 7176 37 . . . cord-010119-t1x9gknd 7177 1 Results/ Results/ . cord-010119-t1x9gknd 7178 1 Finding finding NN cord-010119-t1x9gknd 7178 2 : : : cord-010119-t1x9gknd 7179 1 PreciseType PreciseType NNP cord-010119-t1x9gknd 7179 2 TM TM NNP cord-010119-t1x9gknd 7179 3 HEA HEA NNP cord-010119-t1x9gknd 7179 4 Molecular Molecular NNP cord-010119-t1x9gknd 7179 5 BeadChip BeadChip NNP cord-010119-t1x9gknd 7179 6 testing testing NN cord-010119-t1x9gknd 7179 7 predicted predict VBD cord-010119-t1x9gknd 7179 8 the the DT cord-010119-t1x9gknd 7179 9 sample sample NN cord-010119-t1x9gknd 7179 10 to to TO cord-010119-t1x9gknd 7179 11 be be VB cord-010119-t1x9gknd 7179 12 K K NNP cord-010119-t1x9gknd 7179 13 - - HYPH cord-010119-t1x9gknd 7179 14 k1 k1 NNP cord-010119-t1x9gknd 7179 15 Kp(a Kp(a NNP cord-010119-t1x9gknd 7179 16 - - HYPH cord-010119-t1x9gknd 7179 17 b1 b1 NNP cord-010119-t1x9gknd 7179 18 ) ) -RRB- cord-010119-t1x9gknd 7180 1 Js(a js(a NN cord-010119-t1x9gknd 7180 2 - - HYPH cord-010119-t1x9gknd 7180 3 b1 b1 NNP cord-010119-t1x9gknd 7180 4 ) ) -RRB- cord-010119-t1x9gknd 7180 5 . . . cord-010119-t1x9gknd 7181 1 KEL KEL NNP cord-010119-t1x9gknd 7181 2 - - HYPH cord-010119-t1x9gknd 7181 3 cDNA cDNA NNP cord-010119-t1x9gknd 7181 4 sequence sequence NN cord-010119-t1x9gknd 7181 5 analysis analysis NN cord-010119-t1x9gknd 7181 6 was be VBD cord-010119-t1x9gknd 7181 7 performed perform VBN cord-010119-t1x9gknd 7181 8 and and CC cord-010119-t1x9gknd 7181 9 detected detect VBN cord-010119-t1x9gknd 7181 10 a a DT cord-010119-t1x9gknd 7181 11 single single JJ cord-010119-t1x9gknd 7181 12 transcript transcript NN cord-010119-t1x9gknd 7181 13 species species NN cord-010119-t1x9gknd 7181 14 with with IN cord-010119-t1x9gknd 7181 15 c.578C c.578C NNP cord-010119-t1x9gknd 7181 16 , , , cord-010119-t1x9gknd 7181 17 c.841C c.841C NNP cord-010119-t1x9gknd 7181 18 , , , cord-010119-t1x9gknd 7181 19 1790 1790 CD cord-010119-t1x9gknd 7181 20 T t NN cord-010119-t1x9gknd 7181 21 , , , cord-010119-t1x9gknd 7181 22 and and CC cord-010119-t1x9gknd 7181 23 missing miss VBG cord-010119-t1x9gknd 7181 24 the the DT cord-010119-t1x9gknd 7181 25 sequences sequence NNS cord-010119-t1x9gknd 7181 26 corresponding correspond VBG cord-010119-t1x9gknd 7181 27 to to IN cord-010119-t1x9gknd 7181 28 exons exon NNS cord-010119-t1x9gknd 7181 29 11 11 CD cord-010119-t1x9gknd 7181 30 , , , cord-010119-t1x9gknd 7181 31 12 12 CD cord-010119-t1x9gknd 7181 32 and and CC cord-010119-t1x9gknd 7181 33 13 13 CD cord-010119-t1x9gknd 7181 34 . . . cord-010119-t1x9gknd 7182 1 Amplification amplification NN cord-010119-t1x9gknd 7182 2 of of IN cord-010119-t1x9gknd 7182 3 the the DT cord-010119-t1x9gknd 7182 4 exons exon NNS cord-010119-t1x9gknd 7182 5 from from IN cord-010119-t1x9gknd 7182 6 gDNA gDNA NNS cord-010119-t1x9gknd 7182 7 did do VBD cord-010119-t1x9gknd 7182 8 not not RB cord-010119-t1x9gknd 7182 9 identify identify VB cord-010119-t1x9gknd 7182 10 any any DT cord-010119-t1x9gknd 7182 11 nucleotide nucleotide JJ cord-010119-t1x9gknd 7182 12 changes change NNS cord-010119-t1x9gknd 7182 13 when when WRB cord-010119-t1x9gknd 7182 14 compared compare VBN cord-010119-t1x9gknd 7182 15 to to IN cord-010119-t1x9gknd 7182 16 the the DT cord-010119-t1x9gknd 7182 17 reference reference NN cord-010119-t1x9gknd 7182 18 sequence sequence NN cord-010119-t1x9gknd 7182 19 and and CC cord-010119-t1x9gknd 7182 20 the the DT cord-010119-t1x9gknd 7182 21 splice splice NN cord-010119-t1x9gknd 7182 22 sites site NNS cord-010119-t1x9gknd 7182 23 were be VBD cord-010119-t1x9gknd 7182 24 intact intact JJ cord-010119-t1x9gknd 7182 25 . . . cord-010119-t1x9gknd 7183 1 cDNA cDNA NNP cord-010119-t1x9gknd 7183 2 analysis analysis NN cord-010119-t1x9gknd 7183 3 was be VBD cord-010119-t1x9gknd 7183 4 repeated repeat VBN cord-010119-t1x9gknd 7183 5 and and CC cord-010119-t1x9gknd 7183 6 the the DT cord-010119-t1x9gknd 7183 7 same same JJ cord-010119-t1x9gknd 7183 8 aberrant aberrant JJ cord-010119-t1x9gknd 7183 9 transcript transcript NN cord-010119-t1x9gknd 7183 10 was be VBD cord-010119-t1x9gknd 7183 11 detected detect VBN cord-010119-t1x9gknd 7183 12 . . . cord-010119-t1x9gknd 7184 1 Adsorption Adsorption NNP cord-010119-t1x9gknd 7184 2 and and CC cord-010119-t1x9gknd 7184 3 elution elution NN cord-010119-t1x9gknd 7184 4 studies study NNS cord-010119-t1x9gknd 7184 5 of of IN cord-010119-t1x9gknd 7184 6 the the DT cord-010119-t1x9gknd 7184 7 k k NNP cord-010119-t1x9gknd 7184 8 antigen antigen NNP cord-010119-t1x9gknd 7184 9 demonstrated demonstrate VBD cord-010119-t1x9gknd 7184 10 weak weak JJ cord-010119-t1x9gknd 7184 11 anti anti JJ cord-010119-t1x9gknd 7184 12 - - JJ cord-010119-t1x9gknd 7184 13 k k JJ cord-010119-t1x9gknd 7184 14 reactive reactive JJ cord-010119-t1x9gknd 7184 15 after after IN cord-010119-t1x9gknd 7184 16 37C 37c CD cord-010119-t1x9gknd 7184 17 incubation incubation NN cord-010119-t1x9gknd 7184 18 at at IN cord-010119-t1x9gknd 7184 19 the the DT cord-010119-t1x9gknd 7184 20 PEG PEG NNP cord-010119-t1x9gknd 7184 21 - - HYPH cord-010119-t1x9gknd 7184 22 IgG IgG NNP cord-010119-t1x9gknd 7184 23 - - HYPH cord-010119-t1x9gknd 7184 24 AGT AGT NNP cord-010119-t1x9gknd 7184 25 phase phase NN cord-010119-t1x9gknd 7184 26 . . . cord-010119-t1x9gknd 7185 1 Conclusion conclusion NN cord-010119-t1x9gknd 7185 2 : : : cord-010119-t1x9gknd 7186 1 Here here RB cord-010119-t1x9gknd 7186 2 we -PRON- PRP cord-010119-t1x9gknd 7186 3 describe describe VBP cord-010119-t1x9gknd 7186 4 a a DT cord-010119-t1x9gknd 7186 5 donor donor NN cord-010119-t1x9gknd 7186 6 homozygous homozygous JJ cord-010119-t1x9gknd 7186 7 for for IN cord-010119-t1x9gknd 7186 8 a a DT cord-010119-t1x9gknd 7186 9 novel novel JJ cord-010119-t1x9gknd 7186 10 KEL*02 KEL*02 . cord-010119-t1x9gknd 7186 11 allele allele NN cord-010119-t1x9gknd 7186 12 . . . cord-010119-t1x9gknd 7187 1 This this DT cord-010119-t1x9gknd 7187 2 donor donor NN cord-010119-t1x9gknd 7187 3 was be VBD cord-010119-t1x9gknd 7187 4 presumed presume VBN cord-010119-t1x9gknd 7187 5 to to TO cord-010119-t1x9gknd 7187 6 have have VB cord-010119-t1x9gknd 7187 7 a a DT cord-010119-t1x9gknd 7187 8 K k NN cord-010119-t1x9gknd 7187 9 0 0 CD cord-010119-t1x9gknd 7187 10 phenotype phenotype NN cord-010119-t1x9gknd 7187 11 based base VBN cord-010119-t1x9gknd 7187 12 on on IN cord-010119-t1x9gknd 7187 13 serology serology NN cord-010119-t1x9gknd 7187 14 , , , cord-010119-t1x9gknd 7187 15 but but CC cord-010119-t1x9gknd 7187 16 after after IN cord-010119-t1x9gknd 7187 17 molecular molecular JJ cord-010119-t1x9gknd 7187 18 testing testing NN cord-010119-t1x9gknd 7187 19 , , , cord-010119-t1x9gknd 7187 20 has have VBZ cord-010119-t1x9gknd 7187 21 been be VBN cord-010119-t1x9gknd 7187 22 reclassified reclassify VBN cord-010119-t1x9gknd 7187 23 as as IN cord-010119-t1x9gknd 7187 24 a a DT cord-010119-t1x9gknd 7187 25 K k NN cord-010119-t1x9gknd 7187 26 mod mod NN cord-010119-t1x9gknd 7187 27 phenotype phenotype NN cord-010119-t1x9gknd 7187 28 with with IN cord-010119-t1x9gknd 7187 29 extremely extremely RB cord-010119-t1x9gknd 7187 30 weak weak JJ cord-010119-t1x9gknd 7187 31 expression expression NN cord-010119-t1x9gknd 7187 32 of of IN cord-010119-t1x9gknd 7187 33 k. k. NNP cord-010119-t1x9gknd 7188 1 The the DT cord-010119-t1x9gknd 7188 2 discovery discovery NN cord-010119-t1x9gknd 7188 3 of of IN cord-010119-t1x9gknd 7188 4 the the DT cord-010119-t1x9gknd 7188 5 aberrant aberrant JJ cord-010119-t1x9gknd 7188 6 transcript transcript NN cord-010119-t1x9gknd 7188 7 led lead VBD cord-010119-t1x9gknd 7188 8 to to IN cord-010119-t1x9gknd 7188 9 adsorption adsorption NN cord-010119-t1x9gknd 7188 10 and and CC cord-010119-t1x9gknd 7188 11 elution elution NN cord-010119-t1x9gknd 7188 12 studies study NNS cord-010119-t1x9gknd 7188 13 to to TO cord-010119-t1x9gknd 7188 14 confirm confirm VB cord-010119-t1x9gknd 7188 15 the the DT cord-010119-t1x9gknd 7188 16 presence presence NN cord-010119-t1x9gknd 7188 17 of of IN cord-010119-t1x9gknd 7188 18 weakly weakly RB cord-010119-t1x9gknd 7188 19 expressed express VBD cord-010119-t1x9gknd 7188 20 k k NNP cord-010119-t1x9gknd 7188 21 antigen antigen NN cord-010119-t1x9gknd 7188 22 on on IN cord-010119-t1x9gknd 7188 23 the the DT cord-010119-t1x9gknd 7188 24 red red JJ cord-010119-t1x9gknd 7188 25 cells cell NNS cord-010119-t1x9gknd 7188 26 . . . cord-010119-t1x9gknd 7189 1 The the DT cord-010119-t1x9gknd 7189 2 11 11 CD cord-010119-t1x9gknd 7189 3 variant variant NN cord-010119-t1x9gknd 7189 4 alleles allele NNS cord-010119-t1x9gknd 7189 5 reported report VBN cord-010119-t1x9gknd 7189 6 to to IN cord-010119-t1x9gknd 7189 7 date date NN cord-010119-t1x9gknd 7189 8 ( ( -LRB- cord-010119-t1x9gknd 7189 9 http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-bloodgroup-terminology/ http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-bloodgroup-terminology/ NN cord-010119-t1x9gknd 7189 10 ) ) -RRB- cord-010119-t1x9gknd 7189 11 are be VBP cord-010119-t1x9gknd 7189 12 associated associate VBN cord-010119-t1x9gknd 7189 13 with with IN cord-010119-t1x9gknd 7189 14 missense missense NN cord-010119-t1x9gknd 7189 15 mutations mutation NNS cord-010119-t1x9gknd 7189 16 . . . cord-010119-t1x9gknd 7190 1 In in IN cord-010119-t1x9gknd 7190 2 contrast contrast NN cord-010119-t1x9gknd 7190 3 , , , cord-010119-t1x9gknd 7190 4 the the DT cord-010119-t1x9gknd 7190 5 allele allele NN cord-010119-t1x9gknd 7190 6 reported report VBN cord-010119-t1x9gknd 7190 7 here here RB cord-010119-t1x9gknd 7190 8 is be VBZ cord-010119-t1x9gknd 7190 9 associated associate VBN cord-010119-t1x9gknd 7190 10 aberrant aberrant JJ cord-010119-t1x9gknd 7190 11 mRNA mRNA NNP cord-010119-t1x9gknd 7190 12 transcript transcript NN cord-010119-t1x9gknd 7190 13 . . . cord-010119-t1x9gknd 7191 1 We -PRON- PRP cord-010119-t1x9gknd 7191 2 propose propose VBP cord-010119-t1x9gknd 7191 3 that that IN cord-010119-t1x9gknd 7191 4 this this DT cord-010119-t1x9gknd 7191 5 allele allele NN cord-010119-t1x9gknd 7191 6 be be VB cord-010119-t1x9gknd 7191 7 named name VBN cord-010119-t1x9gknd 7191 8 KEL*02M.12 KEL*02M.12 NNP cord-010119-t1x9gknd 7191 9 . . . cord-010119-t1x9gknd 7192 1 Here here RB cord-010119-t1x9gknd 7192 2 we -PRON- PRP cord-010119-t1x9gknd 7192 3 report report VBP cord-010119-t1x9gknd 7192 4 a a DT cord-010119-t1x9gknd 7192 5 case case NN cord-010119-t1x9gknd 7192 6 of of IN cord-010119-t1x9gknd 7192 7 a a DT cord-010119-t1x9gknd 7192 8 possible possible JJ cord-010119-t1x9gknd 7192 9 novel novel NN cord-010119-t1x9gknd 7192 10 B b NN cord-010119-t1x9gknd 7192 11 subgroup subgroup NN cord-010119-t1x9gknd 7192 12 observed observe VBD cord-010119-t1x9gknd 7192 13 in in IN cord-010119-t1x9gknd 7192 14 a a DT cord-010119-t1x9gknd 7192 15 pregnant pregnant JJ cord-010119-t1x9gknd 7192 16 black black JJ cord-010119-t1x9gknd 7192 17 female female NN cord-010119-t1x9gknd 7192 18 . . . cord-010119-t1x9gknd 7193 1 The the DT cord-010119-t1x9gknd 7193 2 patient patient NN cord-010119-t1x9gknd 7193 3 specimen specimen NN cord-010119-t1x9gknd 7193 4 was be VBD cord-010119-t1x9gknd 7193 5 referred refer VBN cord-010119-t1x9gknd 7193 6 to to IN cord-010119-t1x9gknd 7193 7 our -PRON- PRP$ cord-010119-t1x9gknd 7193 8 reference reference NN cord-010119-t1x9gknd 7193 9 laboratory laboratory NN cord-010119-t1x9gknd 7193 10 to to TO cord-010119-t1x9gknd 7193 11 investigate investigate VB cord-010119-t1x9gknd 7193 12 a a DT cord-010119-t1x9gknd 7193 13 possible possible JJ cord-010119-t1x9gknd 7193 14 ABO ABO NNP cord-010119-t1x9gknd 7193 15 discrepancy discrepancy NN cord-010119-t1x9gknd 7193 16 . . . cord-010119-t1x9gknd 7194 1 The the DT cord-010119-t1x9gknd 7194 2 referring refer VBG cord-010119-t1x9gknd 7194 3 facility facility NN cord-010119-t1x9gknd 7194 4 reported report VBD cord-010119-t1x9gknd 7194 5 the the DT cord-010119-t1x9gknd 7194 6 patient patient NN cord-010119-t1x9gknd 7194 7 's 's POS cord-010119-t1x9gknd 7194 8 red red JJ cord-010119-t1x9gknd 7194 9 blood blood NN cord-010119-t1x9gknd 7194 10 cells cell NNS cord-010119-t1x9gknd 7194 11 were be VBD cord-010119-t1x9gknd 7194 12 nonreactive nonreactive JJ cord-010119-t1x9gknd 7194 13 with with IN cord-010119-t1x9gknd 7194 14 reagent reagent JJ cord-010119-t1x9gknd 7194 15 anti anti JJ cord-010119-t1x9gknd 7194 16 - - JJ cord-010119-t1x9gknd 7194 17 A a JJ cord-010119-t1x9gknd 7194 18 and and CC cord-010119-t1x9gknd 7194 19 anti anti NN cord-010119-t1x9gknd 7194 20 - - NN cord-010119-t1x9gknd 7194 21 B b NN cord-010119-t1x9gknd 7194 22 and and CC cord-010119-t1x9gknd 7194 23 the the DT cord-010119-t1x9gknd 7194 24 patient patient NN cord-010119-t1x9gknd 7194 25 's 's POS cord-010119-t1x9gknd 7194 26 plasma plasma NN cord-010119-t1x9gknd 7194 27 was be VBD cord-010119-t1x9gknd 7194 28 reactive reactive JJ cord-010119-t1x9gknd 7194 29 with with IN cord-010119-t1x9gknd 7194 30 A a DT cord-010119-t1x9gknd 7194 31 cells cell NNS cord-010119-t1x9gknd 7194 32 , , , cord-010119-t1x9gknd 7194 33 but but CC cord-010119-t1x9gknd 7194 34 nonreactive nonreactive JJ cord-010119-t1x9gknd 7194 35 with with IN cord-010119-t1x9gknd 7194 36 B b NN cord-010119-t1x9gknd 7194 37 cells cell NNS cord-010119-t1x9gknd 7194 38 using use VBG cord-010119-t1x9gknd 7194 39 automated automate VBN cord-010119-t1x9gknd 7194 40 gel gel NN cord-010119-t1x9gknd 7194 41 methodology methodology NN cord-010119-t1x9gknd 7194 42 . . . cord-010119-t1x9gknd 7195 1 Study Study NNP cord-010119-t1x9gknd 7195 2 Design Design NNP cord-010119-t1x9gknd 7195 3 / / SYM cord-010119-t1x9gknd 7195 4 Methods method NNS cord-010119-t1x9gknd 7195 5 : : : cord-010119-t1x9gknd 7195 6 Serological serological JJ cord-010119-t1x9gknd 7195 7 testing testing NN cord-010119-t1x9gknd 7195 8 of of IN cord-010119-t1x9gknd 7195 9 the the DT cord-010119-t1x9gknd 7195 10 patient patient NN cord-010119-t1x9gknd 7195 11 's 's POS cord-010119-t1x9gknd 7195 12 red red JJ cord-010119-t1x9gknd 7195 13 blood blood NN cord-010119-t1x9gknd 7195 14 cells cell NNS cord-010119-t1x9gknd 7195 15 was be VBD cord-010119-t1x9gknd 7195 16 performed perform VBN cord-010119-t1x9gknd 7195 17 using use VBG cord-010119-t1x9gknd 7195 18 routine routine NN cord-010119-t1x9gknd 7195 19 and and CC cord-010119-t1x9gknd 7195 20 enhancement enhancement NN cord-010119-t1x9gknd 7195 21 methods method NNS cord-010119-t1x9gknd 7195 22 . . . cord-010119-t1x9gknd 7196 1 Molecular molecular JJ cord-010119-t1x9gknd 7196 2 testing testing NN cord-010119-t1x9gknd 7196 3 by by IN cord-010119-t1x9gknd 7196 4 PCR PCR NNP cord-010119-t1x9gknd 7196 5 - - HYPH cord-010119-t1x9gknd 7196 6 RFLP RFLP NNP cord-010119-t1x9gknd 7196 7 was be VBD cord-010119-t1x9gknd 7196 8 performed perform VBN cord-010119-t1x9gknd 7196 9 to to TO cord-010119-t1x9gknd 7196 10 determine determine VB cord-010119-t1x9gknd 7196 11 the the DT cord-010119-t1x9gknd 7196 12 patient patient NN cord-010119-t1x9gknd 7196 13 's 's POS cord-010119-t1x9gknd 7196 14 genetic genetic JJ cord-010119-t1x9gknd 7196 15 ABO ABO NNP cord-010119-t1x9gknd 7196 16 typing type VBG cord-010119-t1x9gknd 7196 17 and and CC cord-010119-t1x9gknd 7196 18 predicted predict VBD cord-010119-t1x9gknd 7196 19 ABO ABO NNP cord-010119-t1x9gknd 7196 20 phenotype phenotype NN cord-010119-t1x9gknd 7196 21 . . . cord-010119-t1x9gknd 7197 1 Results result NNS cord-010119-t1x9gknd 7197 2 / / SYM cord-010119-t1x9gknd 7197 3 Findings finding NNS cord-010119-t1x9gknd 7197 4 : : : cord-010119-t1x9gknd 7198 1 Serological serological JJ cord-010119-t1x9gknd 7198 2 testing testing NN cord-010119-t1x9gknd 7198 3 of of IN cord-010119-t1x9gknd 7198 4 the the DT cord-010119-t1x9gknd 7198 5 patient patient NN cord-010119-t1x9gknd 7198 6 's 's POS cord-010119-t1x9gknd 7198 7 red red JJ cord-010119-t1x9gknd 7198 8 blood blood NN cord-010119-t1x9gknd 7198 9 cells cell NNS cord-010119-t1x9gknd 7198 10 is be VBZ cord-010119-t1x9gknd 7198 11 summarized summarize VBN cord-010119-t1x9gknd 7198 12 in in IN cord-010119-t1x9gknd 7198 13 Table Table NNP cord-010119-t1x9gknd 7198 14 1 1 CD cord-010119-t1x9gknd 7198 15 ; ; , cord-010119-t1x9gknd 7198 16 similar similar JJ cord-010119-t1x9gknd 7198 17 results result NNS cord-010119-t1x9gknd 7198 18 were be VBD cord-010119-t1x9gknd 7198 19 obtained obtain VBN cord-010119-t1x9gknd 7198 20 with with IN cord-010119-t1x9gknd 7198 21 multiple multiple JJ cord-010119-t1x9gknd 7198 22 sources source NNS cord-010119-t1x9gknd 7198 23 of of IN cord-010119-t1x9gknd 7198 24 antisera antisera NN cord-010119-t1x9gknd 7198 25 . . . cord-010119-t1x9gknd 7199 1 Enzyme enzyme NN cord-010119-t1x9gknd 7199 2 treatment treatment NN cord-010119-t1x9gknd 7199 3 failed fail VBD cord-010119-t1x9gknd 7199 4 to to TO cord-010119-t1x9gknd 7199 5 enhance enhance VB cord-010119-t1x9gknd 7199 6 reactivity reactivity NN cord-010119-t1x9gknd 7199 7 . . . cord-010119-t1x9gknd 7200 1 Patient Patient NNP cord-010119-t1x9gknd 7200 2 sera sera NNP cord-010119-t1x9gknd 7200 3 strongly strongly RB cord-010119-t1x9gknd 7200 4 agglutinated agglutinate VBD cord-010119-t1x9gknd 7200 5 A1 A1 NNP cord-010119-t1x9gknd 7200 6 and and CC cord-010119-t1x9gknd 7200 7 A2 A2 NNP cord-010119-t1x9gknd 7200 8 cells cell NNS cord-010119-t1x9gknd 7200 9 , , , cord-010119-t1x9gknd 7200 10 but but CC cord-010119-t1x9gknd 7200 11 failed fail VBD cord-010119-t1x9gknd 7200 12 to to TO cord-010119-t1x9gknd 7200 13 agglutinate agglutinate VB cord-010119-t1x9gknd 7200 14 multiple multiple JJ cord-010119-t1x9gknd 7200 15 sources source NNS cord-010119-t1x9gknd 7200 16 of of IN cord-010119-t1x9gknd 7200 17 B b NN cord-010119-t1x9gknd 7200 18 cells cell NNS cord-010119-t1x9gknd 7200 19 at at IN cord-010119-t1x9gknd 7200 20 all all DT cord-010119-t1x9gknd 7200 21 phases phase NNS cord-010119-t1x9gknd 7200 22 of of IN cord-010119-t1x9gknd 7200 23 testing testing NN cord-010119-t1x9gknd 7200 24 . . . cord-010119-t1x9gknd 7201 1 Molecular molecular JJ cord-010119-t1x9gknd 7201 2 testing testing NN cord-010119-t1x9gknd 7201 3 by by IN cord-010119-t1x9gknd 7201 4 PCR PCR NNP cord-010119-t1x9gknd 7201 5 - - HYPH cord-010119-t1x9gknd 7201 6 RFLP RFLP NNP cord-010119-t1x9gknd 7201 7 resulted result VBD cord-010119-t1x9gknd 7201 8 in in IN cord-010119-t1x9gknd 7201 9 an an DT cord-010119-t1x9gknd 7201 10 uncommon uncommon JJ cord-010119-t1x9gknd 7201 11 banding banding NN cord-010119-t1x9gknd 7201 12 pattern pattern NN cord-010119-t1x9gknd 7201 13 and and CC cord-010119-t1x9gknd 7201 14 indicated indicate VBD cord-010119-t1x9gknd 7201 15 the the DT cord-010119-t1x9gknd 7201 16 presence presence NN cord-010119-t1x9gknd 7201 17 of of IN cord-010119-t1x9gknd 7201 18 c.261 c.261 NNS cord-010119-t1x9gknd 7201 19 deleted delete VBD cord-010119-t1x9gknd 7201 20 G g NN cord-010119-t1x9gknd 7201 21 , , , cord-010119-t1x9gknd 7201 22 characteristic characteristic NN cord-010119-t1x9gknd 7201 23 of of IN cord-010119-t1x9gknd 7201 24 O o NN cord-010119-t1x9gknd 7201 25 alleles allele NNS cord-010119-t1x9gknd 7201 26 , , , cord-010119-t1x9gknd 7201 27 c.467 c.467 NNP cord-010119-t1x9gknd 7201 28 T t NN cord-010119-t1x9gknd 7201 29 , , , cord-010119-t1x9gknd 7201 30 characteristic characteristic NN cord-010119-t1x9gknd 7201 31 of of IN cord-010119-t1x9gknd 7201 32 A2 a2 NN cord-010119-t1x9gknd 7201 33 and and CC cord-010119-t1x9gknd 7201 34 some some DT cord-010119-t1x9gknd 7201 35 uncommon uncommon JJ cord-010119-t1x9gknd 7201 36 O o NN cord-010119-t1x9gknd 7201 37 alleles allele NNS cord-010119-t1x9gknd 7201 38 , , , cord-010119-t1x9gknd 7201 39 and and CC cord-010119-t1x9gknd 7201 40 c.703A c.703A NNP cord-010119-t1x9gknd 7201 41 and and CC cord-010119-t1x9gknd 7201 42 c.1096A c.1096a CD cord-010119-t1x9gknd 7201 43 , , , cord-010119-t1x9gknd 7201 44 characteristic characteristic NN cord-010119-t1x9gknd 7201 45 of of IN cord-010119-t1x9gknd 7201 46 B b NN cord-010119-t1x9gknd 7201 47 alleles allele NNS cord-010119-t1x9gknd 7201 48 . . . cord-010119-t1x9gknd 7202 1 Genomic genomic JJ cord-010119-t1x9gknd 7202 2 sequencing sequencing NN cord-010119-t1x9gknd 7202 3 of of IN cord-010119-t1x9gknd 7202 4 exons exon NNS cord-010119-t1x9gknd 7202 5 6 6 CD cord-010119-t1x9gknd 7202 6 and and CC cord-010119-t1x9gknd 7202 7 7 7 CD cord-010119-t1x9gknd 7202 8 confirmed confirm VBD cord-010119-t1x9gknd 7202 9 the the DT cord-010119-t1x9gknd 7202 10 presence presence NN cord-010119-t1x9gknd 7202 11 of of IN cord-010119-t1x9gknd 7202 12 an an DT cord-010119-t1x9gknd 7202 13 O o NN cord-010119-t1x9gknd 7202 14 allele allele NN cord-010119-t1x9gknd 7202 15 , , , cord-010119-t1x9gknd 7202 16 ABO*O09 abo*o09 IN cord-010119-t1x9gknd 7202 17 261del 261del CD cord-010119-t1x9gknd 7202 18 G G NNP cord-010119-t1x9gknd 7202 19 , , , cord-010119-t1x9gknd 7202 20 318 318 CD cord-010119-t1x9gknd 7202 21 T t NN cord-010119-t1x9gknd 7202 22 , , , cord-010119-t1x9gknd 7202 23 467 467 CD cord-010119-t1x9gknd 7202 24 T T NNP cord-010119-t1x9gknd 7202 25 ) ) -RRB- cord-010119-t1x9gknd 7202 26 , , , cord-010119-t1x9gknd 7202 27 and and CC cord-010119-t1x9gknd 7202 28 the the DT cord-010119-t1x9gknd 7202 29 presence presence NN cord-010119-t1x9gknd 7202 30 of of IN cord-010119-t1x9gknd 7202 31 a a DT cord-010119-t1x9gknd 7202 32 B b NN cord-010119-t1x9gknd 7202 33 allele allele NN cord-010119-t1x9gknd 7202 34 ( ( -LRB- cord-010119-t1x9gknd 7202 35 297 297 CD cord-010119-t1x9gknd 7202 36 G g NN cord-010119-t1x9gknd 7202 37 , , , cord-010119-t1x9gknd 7202 38 526 526 CD cord-010119-t1x9gknd 7202 39 G g NN cord-010119-t1x9gknd 7202 40 , , , cord-010119-t1x9gknd 7202 41 657 657 CD cord-010119-t1x9gknd 7202 42 T t NN cord-010119-t1x9gknd 7202 43 , , , cord-010119-t1x9gknd 7202 44 703A 703a CD cord-010119-t1x9gknd 7202 45 , , , cord-010119-t1x9gknd 7202 46 796A 796a CD cord-010119-t1x9gknd 7202 47 , , , cord-010119-t1x9gknd 7202 48 803C 803c CD cord-010119-t1x9gknd 7202 49 , , , cord-010119-t1x9gknd 7202 50 and and CC cord-010119-t1x9gknd 7202 51 930A 930a CD cord-010119-t1x9gknd 7202 52 ) ) -RRB- cord-010119-t1x9gknd 7202 53 , , , cord-010119-t1x9gknd 7202 54 but but CC cord-010119-t1x9gknd 7202 55 did do VBD cord-010119-t1x9gknd 7202 56 not not RB cord-010119-t1x9gknd 7202 57 reveal reveal VB cord-010119-t1x9gknd 7202 58 any any DT cord-010119-t1x9gknd 7202 59 changes change NNS cord-010119-t1x9gknd 7202 60 associated associate VBN cord-010119-t1x9gknd 7202 61 with with IN cord-010119-t1x9gknd 7202 62 previously previously RB cord-010119-t1x9gknd 7202 63 reported report VBN cord-010119-t1x9gknd 7202 64 weak weak JJ cord-010119-t1x9gknd 7202 65 subgroups subgroup NNS cord-010119-t1x9gknd 7202 66 of of IN cord-010119-t1x9gknd 7202 67 B. B. NNP cord-010119-t1x9gknd 7202 68 Conclusion Conclusion NNP cord-010119-t1x9gknd 7202 69 : : : cord-010119-t1x9gknd 7203 1 While while IN cord-010119-t1x9gknd 7203 2 serologic serologic JJ cord-010119-t1x9gknd 7203 3 abnormalities abnormality NNS cord-010119-t1x9gknd 7203 4 in in IN cord-010119-t1x9gknd 7203 5 pregnancy pregnancy NN cord-010119-t1x9gknd 7203 6 have have VBP cord-010119-t1x9gknd 7203 7 been be VBN cord-010119-t1x9gknd 7203 8 reported report VBN cord-010119-t1x9gknd 7203 9 due due IN cord-010119-t1x9gknd 7203 10 to to IN cord-010119-t1x9gknd 7203 11 decreased decrease VBN cord-010119-t1x9gknd 7203 12 antigen antigen NN cord-010119-t1x9gknd 7203 13 expression expression NN cord-010119-t1x9gknd 7203 14 , , , cord-010119-t1x9gknd 7203 15 the the DT cord-010119-t1x9gknd 7203 16 unusually unusually RB cord-010119-t1x9gknd 7203 17 weak weak JJ cord-010119-t1x9gknd 7203 18 reactions reaction NNS cord-010119-t1x9gknd 7203 19 observed observe VBD cord-010119-t1x9gknd 7203 20 when when WRB cord-010119-t1x9gknd 7203 21 testing test VBG cord-010119-t1x9gknd 7203 22 this this DT cord-010119-t1x9gknd 7203 23 patient patient NN cord-010119-t1x9gknd 7203 24 are be VBP cord-010119-t1x9gknd 7203 25 unlikely unlikely JJ cord-010119-t1x9gknd 7203 26 due due IN cord-010119-t1x9gknd 7203 27 to to IN cord-010119-t1x9gknd 7203 28 pregnancy pregnancy NN cord-010119-t1x9gknd 7203 29 alone alone RB cord-010119-t1x9gknd 7203 30 . . . cord-010119-t1x9gknd 7204 1 Additional additional JJ cord-010119-t1x9gknd 7204 2 ABO ABO NNP cord-010119-t1x9gknd 7204 3 gene gene NN cord-010119-t1x9gknd 7204 4 sequencing sequencing NN cord-010119-t1x9gknd 7204 5 is be VBZ cord-010119-t1x9gknd 7204 6 required require VBN cord-010119-t1x9gknd 7204 7 to to TO cord-010119-t1x9gknd 7204 8 determine determine VB cord-010119-t1x9gknd 7204 9 the the DT cord-010119-t1x9gknd 7204 10 specific specific JJ cord-010119-t1x9gknd 7204 11 allele allele NN cord-010119-t1x9gknd 7204 12 mutation mutation NN cord-010119-t1x9gknd 7204 13 responsible responsible JJ cord-010119-t1x9gknd 7204 14 for for IN cord-010119-t1x9gknd 7204 15 this this DT cord-010119-t1x9gknd 7204 16 weakened weaken VBN cord-010119-t1x9gknd 7204 17 antigen antigen NN cord-010119-t1x9gknd 7204 18 expression expression NN cord-010119-t1x9gknd 7204 19 . . . cord-010119-t1x9gknd 7205 1 Carine Carine NNP cord-010119-t1x9gknd 7205 2 Arnoni Arnoni NNP cord-010119-t1x9gknd 7205 3 * * NFP cord-010119-t1x9gknd 7205 4 1 1 CD cord-010119-t1x9gknd 7205 5 , , , cord-010119-t1x9gknd 7205 6 Tatiane Tatiane NNP cord-010119-t1x9gknd 7205 7 Vendrame Vendrame NNP cord-010119-t1x9gknd 7205 8 2 2 CD cord-010119-t1x9gknd 7205 9 , , , cord-010119-t1x9gknd 7205 10 Janaína Janaína NNP cord-010119-t1x9gknd 7205 11 Muniz Muniz NNP cord-010119-t1x9gknd 7205 12 3 3 CD cord-010119-t1x9gknd 7205 13 , , , cord-010119-t1x9gknd 7205 14 Diana Diana NNP cord-010119-t1x9gknd 7205 15 Gazito Gazito NNP cord-010119-t1x9gknd 7205 16 2 2 CD cord-010119-t1x9gknd 7205 17 , , , cord-010119-t1x9gknd 7205 18 Afonso Afonso NNP cord-010119-t1x9gknd 7205 19 Cortez Cortez NNP cord-010119-t1x9gknd 7205 20 2 2 CD cord-010119-t1x9gknd 7205 21 , , , cord-010119-t1x9gknd 7205 22 Lilian Lilian NNP cord-010119-t1x9gknd 7205 23 Castilho Castilho NNP cord-010119-t1x9gknd 7205 24 4 4 CD cord-010119-t1x9gknd 7205 25 and and CC cord-010119-t1x9gknd 7205 26 Flavia Flavia NNP cord-010119-t1x9gknd 7205 27 Latini Latini NNP cord-010119-t1x9gknd 7205 28 2 2 CD cord-010119-t1x9gknd 7205 29 . . . cord-010119-t1x9gknd 7206 1 1 1 CD cord-010119-t1x9gknd 7206 2 Associa Associa NNP cord-010119-t1x9gknd 7206 3 , , , cord-010119-t1x9gknd 7206 4 2 2 CD cord-010119-t1x9gknd 7206 5 Associac¸ão associac¸ão NN cord-010119-t1x9gknd 7206 6 Beneficente Beneficente NNP cord-010119-t1x9gknd 7206 7 de de NNP cord-010119-t1x9gknd 7206 8 Coleta Coleta NNP cord-010119-t1x9gknd 7206 9 de de NNP cord-010119-t1x9gknd 7206 10 Sangue Sangue NNP cord-010119-t1x9gknd 7206 11 , , , cord-010119-t1x9gknd 7206 12 3 3 CD cord-010119-t1x9gknd 7206 13 Hemocentro Hemocentro NNP cord-010119-t1x9gknd 7206 14 de de NNP cord-010119-t1x9gknd 7206 15 São São NNP cord-010119-t1x9gknd 7206 16 Jos Jos NNP cord-010119-t1x9gknd 7206 17 e e NNP cord-010119-t1x9gknd 7206 18 do do VBP cord-010119-t1x9gknd 7206 19 Rio Rio NNP cord-010119-t1x9gknd 7206 20 Preto Preto NNP cord-010119-t1x9gknd 7206 21 , , , cord-010119-t1x9gknd 7206 22 4 4 CD cord-010119-t1x9gknd 7206 23 Hemocentro Hemocentro NNP cord-010119-t1x9gknd 7206 24 Unicamp Unicamp NNP cord-010119-t1x9gknd 7206 25 Background Background NNP cord-010119-t1x9gknd 7206 26 / / SYM cord-010119-t1x9gknd 7206 27 Case Case NNP cord-010119-t1x9gknd 7206 28 Studies Studies NNPS cord-010119-t1x9gknd 7206 29 : : : cord-010119-t1x9gknd 7207 1 After after IN cord-010119-t1x9gknd 7207 2 the the DT cord-010119-t1x9gknd 7207 3 elucidation elucidation NN cord-010119-t1x9gknd 7207 4 of of IN cord-010119-t1x9gknd 7207 5 the the DT cord-010119-t1x9gknd 7207 6 molecular molecular JJ cord-010119-t1x9gknd 7207 7 basis basis NN cord-010119-t1x9gknd 7207 8 of of IN cord-010119-t1x9gknd 7207 9 VEL VEL NNP cord-010119-t1x9gknd 7207 10 , , , cord-010119-t1x9gknd 7207 11 molecular molecular JJ cord-010119-t1x9gknd 7207 12 tools tool NNS cord-010119-t1x9gknd 7207 13 have have VBP cord-010119-t1x9gknd 7207 14 been be VBN cord-010119-t1x9gknd 7207 15 used use VBN cord-010119-t1x9gknd 7207 16 to to TO cord-010119-t1x9gknd 7207 17 explain explain VB cord-010119-t1x9gknd 7207 18 the the DT cord-010119-t1x9gknd 7207 19 reduced reduce VBN cord-010119-t1x9gknd 7207 20 expression expression NN cord-010119-t1x9gknd 7207 21 of of IN cord-010119-t1x9gknd 7207 22 Vel Vel NNP cord-010119-t1x9gknd 7207 23 antigen antigen NN cord-010119-t1x9gknd 7207 24 in in IN cord-010119-t1x9gknd 7207 25 different different JJ cord-010119-t1x9gknd 7207 26 populations population NNS cord-010119-t1x9gknd 7207 27 . . . cord-010119-t1x9gknd 7208 1 Negative negative JJ cord-010119-t1x9gknd 7208 2 or or CC cord-010119-t1x9gknd 7208 3 weak weak JJ cord-010119-t1x9gknd 7208 4 reactions reaction NNS cord-010119-t1x9gknd 7208 5 are be VBP cord-010119-t1x9gknd 7208 6 generally generally RB cord-010119-t1x9gknd 7208 7 related relate VBN cord-010119-t1x9gknd 7208 8 to to IN cord-010119-t1x9gknd 7208 9 the the DT cord-010119-t1x9gknd 7208 10 17-bp 17-bp CD cord-010119-t1x9gknd 7208 11 deletion deletion NN cord-010119-t1x9gknd 7208 12 in in IN cord-010119-t1x9gknd 7208 13 SMIM1 SMIM1 NNP cord-010119-t1x9gknd 7208 14 in in IN cord-010119-t1x9gknd 7208 15 homozygous homozygous JJ cord-010119-t1x9gknd 7208 16 or or CC cord-010119-t1x9gknd 7208 17 heterozygous heterozygous JJ cord-010119-t1x9gknd 7208 18 status status NN cord-010119-t1x9gknd 7208 19 . . . cord-010119-t1x9gknd 7209 1 However however RB cord-010119-t1x9gknd 7209 2 , , , cord-010119-t1x9gknd 7209 3 other other JJ cord-010119-t1x9gknd 7209 4 nucleotide nucleotide JJ cord-010119-t1x9gknd 7209 5 changes change NNS cord-010119-t1x9gknd 7209 6 have have VBP cord-010119-t1x9gknd 7209 7 been be VBN cord-010119-t1x9gknd 7209 8 described describe VBN cord-010119-t1x9gknd 7209 9 to to TO cord-010119-t1x9gknd 7209 10 reduce reduce VB cord-010119-t1x9gknd 7209 11 the the DT cord-010119-t1x9gknd 7209 12 Vel Vel NNP cord-010119-t1x9gknd 7209 13 expression expression NN cord-010119-t1x9gknd 7209 14 , , , cord-010119-t1x9gknd 7209 15 as as IN cord-010119-t1x9gknd 7209 16 for for IN cord-010119-t1x9gknd 7209 17 example example NN cord-010119-t1x9gknd 7209 18 , , , cord-010119-t1x9gknd 7209 19 the the DT cord-010119-t1x9gknd 7209 20 major major JJ cord-010119-t1x9gknd 7209 21 A a DT cord-010119-t1x9gknd 7209 22 allele allele NN cord-010119-t1x9gknd 7209 23 of of IN cord-010119-t1x9gknd 7209 24 the the DT cord-010119-t1x9gknd 7209 25 SNP SNP NNP cord-010119-t1x9gknd 7209 26 rs1175550 rs1175550 NNP cord-010119-t1x9gknd 7209 27 located locate VBN cord-010119-t1x9gknd 7209 28 in in IN cord-010119-t1x9gknd 7209 29 the the DT cord-010119-t1x9gknd 7209 30 second second JJ cord-010119-t1x9gknd 7209 31 intron intron NN cord-010119-t1x9gknd 7209 32 of of IN cord-010119-t1x9gknd 7209 33 the the DT cord-010119-t1x9gknd 7209 34 gene gene NN cord-010119-t1x9gknd 7209 35 , , , cord-010119-t1x9gknd 7209 36 a a DT cord-010119-t1x9gknd 7209 37 regulatory regulatory JJ cord-010119-t1x9gknd 7209 38 region region NN cord-010119-t1x9gknd 7209 39 in in IN cord-010119-t1x9gknd 7209 40 erythroblasts erythroblast NNS cord-010119-t1x9gknd 7209 41 . . . cord-010119-t1x9gknd 7210 1 This this DT cord-010119-t1x9gknd 7210 2 study study NN cord-010119-t1x9gknd 7210 3 aimed aim VBD cord-010119-t1x9gknd 7210 4 to to TO cord-010119-t1x9gknd 7210 5 characterize characterize VB cord-010119-t1x9gknd 7210 6 the the DT cord-010119-t1x9gknd 7210 7 genetic genetic JJ cord-010119-t1x9gknd 7210 8 changes change NNS cord-010119-t1x9gknd 7210 9 related relate VBN cord-010119-t1x9gknd 7210 10 to to IN cord-010119-t1x9gknd 7210 11 atypical atypical JJ cord-010119-t1x9gknd 7210 12 Vel Vel NNP cord-010119-t1x9gknd 7210 13 expression expression NN cord-010119-t1x9gknd 7210 14 in in IN cord-010119-t1x9gknd 7210 15 a a DT cord-010119-t1x9gknd 7210 16 Brazilian brazilian JJ cord-010119-t1x9gknd 7210 17 population population NN cord-010119-t1x9gknd 7210 18 . . . cord-010119-t1x9gknd 7211 1 Study Study NNP cord-010119-t1x9gknd 7211 2 Design Design NNP cord-010119-t1x9gknd 7211 3 / / SYM cord-010119-t1x9gknd 7211 4 Method method NN cord-010119-t1x9gknd 7211 5 : : : cord-010119-t1x9gknd 7212 1 A a DT cord-010119-t1x9gknd 7212 2 total total NN cord-010119-t1x9gknd 7212 3 of of IN cord-010119-t1x9gknd 7212 4 400 400 CD cord-010119-t1x9gknd 7212 5 blood blood NN cord-010119-t1x9gknd 7212 6 donor donor NN cord-010119-t1x9gknd 7212 7 samples sample NNS cord-010119-t1x9gknd 7212 8 from from IN cord-010119-t1x9gknd 7212 9 the the DT cord-010119-t1x9gknd 7212 10 Southeast Southeast NNP cord-010119-t1x9gknd 7212 11 region region NN cord-010119-t1x9gknd 7212 12 of of IN cord-010119-t1x9gknd 7212 13 Brazil Brazil NNP cord-010119-t1x9gknd 7212 14 were be VBD cord-010119-t1x9gknd 7212 15 typed type VBN cord-010119-t1x9gknd 7212 16 for for IN cord-010119-t1x9gknd 7212 17 Vel Vel NNP cord-010119-t1x9gknd 7212 18 with with IN cord-010119-t1x9gknd 7212 19 an an DT cord-010119-t1x9gknd 7212 20 anti anti JJ cord-010119-t1x9gknd 7212 21 - - JJ cord-010119-t1x9gknd 7212 22 Vel vel JJ cord-010119-t1x9gknd 7212 23 serum serum NN cord-010119-t1x9gknd 7212 24 from from IN cord-010119-t1x9gknd 7212 25 our -PRON- PRP$ cord-010119-t1x9gknd 7212 26 inventory inventory NN cord-010119-t1x9gknd 7212 27 in in IN cord-010119-t1x9gknd 7212 28 GEL gel NN cord-010119-t1x9gknd 7212 29 - - HYPH cord-010119-t1x9gknd 7212 30 IAT IAT NNP cord-010119-t1x9gknd 7212 31 . . . cord-010119-t1x9gknd 7213 1 Samples sample NNS cord-010119-t1x9gknd 7213 2 typed type VBN cord-010119-t1x9gknd 7213 3 as as IN cord-010119-t1x9gknd 7213 4 Vel Vel NNP cord-010119-t1x9gknd 7213 5 - - HYPH cord-010119-t1x9gknd 7213 6 negative negative JJ cord-010119-t1x9gknd 7213 7 were be VBD cord-010119-t1x9gknd 7213 8 further further RB cord-010119-t1x9gknd 7213 9 analyzed analyze VBN cord-010119-t1x9gknd 7213 10 by by IN cord-010119-t1x9gknd 7213 11 adsorption adsorption NN cord-010119-t1x9gknd 7213 12 - - HYPH cord-010119-t1x9gknd 7213 13 elution elution NN cord-010119-t1x9gknd 7213 14 . . . cord-010119-t1x9gknd 7214 1 Molecular molecular JJ cord-010119-t1x9gknd 7214 2 study study NN cord-010119-t1x9gknd 7214 3 was be VBD cord-010119-t1x9gknd 7214 4 performed perform VBN cord-010119-t1x9gknd 7214 5 in in IN cord-010119-t1x9gknd 7214 6 samples sample NNS cord-010119-t1x9gknd 7214 7 with with IN cord-010119-t1x9gknd 7214 8 negative negative JJ cord-010119-t1x9gknd 7214 9 results result NNS cord-010119-t1x9gknd 7214 10 , , , cord-010119-t1x9gknd 7214 11 in in IN cord-010119-t1x9gknd 7214 12 samples sample NNS cord-010119-t1x9gknd 7214 13 reacting react VBG cord-010119-t1x9gknd 7214 14 21 21 CD cord-010119-t1x9gknd 7214 15 and and CC cord-010119-t1x9gknd 7214 16 in in IN cord-010119-t1x9gknd 7214 17 samples sample NNS cord-010119-t1x9gknd 7214 18 with with IN cord-010119-t1x9gknd 7214 19 reactivity reactivity NN cord-010119-t1x9gknd 7214 20 of of IN cord-010119-t1x9gknd 7214 21 31 31 CD cord-010119-t1x9gknd 7214 22 . . . cord-010119-t1x9gknd 7215 1 DNA DNA NNP cord-010119-t1x9gknd 7215 2 was be VBD cord-010119-t1x9gknd 7215 3 isolated isolate VBN cord-010119-t1x9gknd 7215 4 from from IN cord-010119-t1x9gknd 7215 5 peripheral peripheral JJ cord-010119-t1x9gknd 7215 6 blood blood NN cord-010119-t1x9gknd 7215 7 and and CC cord-010119-t1x9gknd 7215 8 SMIM1 SMIM1 NNP cord-010119-t1x9gknd 7215 9 was be VBD cord-010119-t1x9gknd 7215 10 sequenced sequence VBN cord-010119-t1x9gknd 7215 11 . . . cord-010119-t1x9gknd 7216 1 Results/ Results/ . cord-010119-t1x9gknd 7217 1 Finding find VBG cord-010119-t1x9gknd 7218 1 : : : cord-010119-t1x9gknd 7218 2 From from IN cord-010119-t1x9gknd 7218 3 400 400 CD cord-010119-t1x9gknd 7218 4 donor donor NN cord-010119-t1x9gknd 7218 5 samples sample NNS cord-010119-t1x9gknd 7218 6 studied study VBD cord-010119-t1x9gknd 7218 7 , , , cord-010119-t1x9gknd 7218 8 4 4 CD cord-010119-t1x9gknd 7218 9 were be VBD cord-010119-t1x9gknd 7218 10 serologically serologically RB cord-010119-t1x9gknd 7218 11 Vel Vel NNP cord-010119-t1x9gknd 7218 12 negative negative NN cord-010119-t1x9gknd 7218 13 by by IN cord-010119-t1x9gknd 7218 14 GEL gel NN cord-010119-t1x9gknd 7218 15 - - HYPH cord-010119-t1x9gknd 7218 16 IAT IAT NNP cord-010119-t1x9gknd 7218 17 but but CC cord-010119-t1x9gknd 7218 18 positive positive JJ cord-010119-t1x9gknd 7218 19 by by IN cord-010119-t1x9gknd 7218 20 adsorption adsorption NN cord-010119-t1x9gknd 7218 21 - - HYPH cord-010119-t1x9gknd 7218 22 elution elution NN cord-010119-t1x9gknd 7218 23 , , , cord-010119-t1x9gknd 7218 24 158 158 CD cord-010119-t1x9gknd 7218 25 presented present VBD cord-010119-t1x9gknd 7218 26 a a DT cord-010119-t1x9gknd 7218 27 21 21 CD cord-010119-t1x9gknd 7218 28 reaction reaction NN cord-010119-t1x9gknd 7218 29 and and CC cord-010119-t1x9gknd 7218 30 the the DT cord-010119-t1x9gknd 7218 31 remained remain VBN cord-010119-t1x9gknd 7218 32 samples sample NNS cord-010119-t1x9gknd 7218 33 showed show VBD cord-010119-t1x9gknd 7218 34 a a DT cord-010119-t1x9gknd 7218 35 reactivity reactivity NN cord-010119-t1x9gknd 7218 36 of of IN cord-010119-t1x9gknd 7218 37 31 31 CD cord-010119-t1x9gknd 7218 38 . . . cord-010119-t1x9gknd 7219 1 Genotyping genotyping NN cord-010119-t1x9gknd 7219 2 results result NNS cord-010119-t1x9gknd 7219 3 showed show VBD cord-010119-t1x9gknd 7219 4 that that IN cord-010119-t1x9gknd 7219 5 the the DT cord-010119-t1x9gknd 7219 6 4 4 CD cord-010119-t1x9gknd 7219 7 samples sample NNS cord-010119-t1x9gknd 7219 8 with with IN cord-010119-t1x9gknd 7219 9 negative negative JJ cord-010119-t1x9gknd 7219 10 results result NNS cord-010119-t1x9gknd 7219 11 and and CC cord-010119-t1x9gknd 7219 12 5 5 CD cord-010119-t1x9gknd 7219 13 of of IN cord-010119-t1x9gknd 7219 14 26 26 CD cord-010119-t1x9gknd 7219 15 samples sample NNS cord-010119-t1x9gknd 7219 16 that that WDT cord-010119-t1x9gknd 7219 17 presented present VBD cord-010119-t1x9gknd 7219 18 21 21 CD cord-010119-t1x9gknd 7219 19 reaction reaction NN cord-010119-t1x9gknd 7219 20 were be VBD cord-010119-t1x9gknd 7219 21 heterozygous heterozygous JJ cord-010119-t1x9gknd 7219 22 for for IN cord-010119-t1x9gknd 7219 23 the the DT cord-010119-t1x9gknd 7219 24 17 17 CD cord-010119-t1x9gknd 7219 25 bp bp NNP cord-010119-t1x9gknd 7219 26 deletion deletion NN cord-010119-t1x9gknd 7219 27 and and CC cord-010119-t1x9gknd 7219 28 presented present VBD cord-010119-t1x9gknd 7219 29 the the DT cord-010119-t1x9gknd 7219 30 A a DT cord-010119-t1x9gknd 7219 31 allele allele NN cord-010119-t1x9gknd 7219 32 rs1175550 rs1175550 NN cord-010119-t1x9gknd 7219 33 in in IN cord-010119-t1x9gknd 7219 34 homozygous homozygous JJ cord-010119-t1x9gknd 7219 35 status status NN cord-010119-t1x9gknd 7219 36 . . . cord-010119-t1x9gknd 7220 1 From from IN cord-010119-t1x9gknd 7220 2 the the DT cord-010119-t1x9gknd 7220 3 21 21 CD cord-010119-t1x9gknd 7220 4 of of IN cord-010119-t1x9gknd 7220 5 26 26 CD cord-010119-t1x9gknd 7220 6 remaining remain VBG cord-010119-t1x9gknd 7220 7 samples sample NNS cord-010119-t1x9gknd 7220 8 with with IN cord-010119-t1x9gknd 7220 9 reactivity reactivity NN cord-010119-t1x9gknd 7220 10 of of IN cord-010119-t1x9gknd 7220 11 21 21 CD cord-010119-t1x9gknd 7220 12 , , , cord-010119-t1x9gknd 7220 13 19 19 CD cord-010119-t1x9gknd 7220 14 ( ( -LRB- cord-010119-t1x9gknd 7220 15 90 90 CD cord-010119-t1x9gknd 7220 16 % % NN cord-010119-t1x9gknd 7220 17 ) ) -RRB- cord-010119-t1x9gknd 7220 18 had have VBD cord-010119-t1x9gknd 7220 19 the the DT cord-010119-t1x9gknd 7220 20 A a DT cord-010119-t1x9gknd 7220 21 allele allele NN cord-010119-t1x9gknd 7220 22 of of IN cord-010119-t1x9gknd 7220 23 rs1175550 rs1175550 NN cord-010119-t1x9gknd 7220 24 and and CC cord-010119-t1x9gknd 7220 25 14 14 CD cord-010119-t1x9gknd 7220 26 ( ( -LRB- cord-010119-t1x9gknd 7220 27 66.7 66.7 CD cord-010119-t1x9gknd 7220 28 % % NN cord-010119-t1x9gknd 7220 29 ) ) -RRB- cord-010119-t1x9gknd 7220 30 had have VBD cord-010119-t1x9gknd 7220 31 the the DT cord-010119-t1x9gknd 7220 32 A a DT cord-010119-t1x9gknd 7220 33 allele allele NN cord-010119-t1x9gknd 7220 34 of of IN cord-010119-t1x9gknd 7220 35 rs6673829 rs6673829 NNP cord-010119-t1x9gknd 7220 36 . . . cord-010119-t1x9gknd 7221 1 In in IN cord-010119-t1x9gknd 7221 2 contrast contrast NN cord-010119-t1x9gknd 7221 3 , , , cord-010119-t1x9gknd 7221 4 in in IN cord-010119-t1x9gknd 7221 5 the the DT cord-010119-t1x9gknd 7221 6 16 16 CD cord-010119-t1x9gknd 7221 7 samples sample NNS cord-010119-t1x9gknd 7221 8 with with IN cord-010119-t1x9gknd 7221 9 stronger strong JJR cord-010119-t1x9gknd 7221 10 reactions reaction NNS cord-010119-t1x9gknd 7221 11 we -PRON- PRP cord-010119-t1x9gknd 7221 12 found find VBD cord-010119-t1x9gknd 7221 13 the the DT cord-010119-t1x9gknd 7221 14 A a DT cord-010119-t1x9gknd 7221 15 allele allele NN cord-010119-t1x9gknd 7221 16 of of IN cord-010119-t1x9gknd 7221 17 rs1175550 rs1175550 NN cord-010119-t1x9gknd 7221 18 in in IN cord-010119-t1x9gknd 7221 19 5 5 CD cord-010119-t1x9gknd 7221 20 ( ( -LRB- cord-010119-t1x9gknd 7221 21 31.25 31.25 CD cord-010119-t1x9gknd 7221 22 % % NN cord-010119-t1x9gknd 7221 23 ) ) -RRB- cord-010119-t1x9gknd 7221 24 samples sample NNS cord-010119-t1x9gknd 7221 25 and and CC cord-010119-t1x9gknd 7221 26 the the DT cord-010119-t1x9gknd 7221 27 A a DT cord-010119-t1x9gknd 7221 28 allele allele NN cord-010119-t1x9gknd 7221 29 of of IN cord-010119-t1x9gknd 7221 30 rs6673829 rs6673829 NN cord-010119-t1x9gknd 7221 31 in in IN cord-010119-t1x9gknd 7221 32 3 3 CD cord-010119-t1x9gknd 7221 33 ( ( -LRB- cord-010119-t1x9gknd 7221 34 18.75 18.75 CD cord-010119-t1x9gknd 7221 35 % % NN cord-010119-t1x9gknd 7221 36 ) ) -RRB- cord-010119-t1x9gknd 7221 37 samples sample NNS cord-010119-t1x9gknd 7221 38 . . . cord-010119-t1x9gknd 7222 1 Conclusion conclusion NN cord-010119-t1x9gknd 7222 2 : : : cord-010119-t1x9gknd 7223 1 The the DT cord-010119-t1x9gknd 7223 2 molecular molecular JJ cord-010119-t1x9gknd 7223 3 changes change NNS cord-010119-t1x9gknd 7224 1 rs6673829 rs6673829 NNP cord-010119-t1x9gknd 7224 2 and and CC cord-010119-t1x9gknd 7224 3 rs1175550 rs1175550 NN cord-010119-t1x9gknd 7224 4 are be VBP cord-010119-t1x9gknd 7224 5 located locate VBN cord-010119-t1x9gknd 7224 6 in in IN cord-010119-t1x9gknd 7224 7 intron intron NN cord-010119-t1x9gknd 7224 8 2 2 CD cord-010119-t1x9gknd 7224 9 distancing distance VBG cord-010119-t1x9gknd 7224 10 38 38 CD cord-010119-t1x9gknd 7224 11 nucleotides nucleotide NNS cord-010119-t1x9gknd 7224 12 . . . cord-010119-t1x9gknd 7225 1 This this DT cord-010119-t1x9gknd 7225 2 study study NN cord-010119-t1x9gknd 7225 3 reinforces reinforce VBZ cord-010119-t1x9gknd 7225 4 the the DT cord-010119-t1x9gknd 7225 5 association association NN cord-010119-t1x9gknd 7225 6 of of IN cord-010119-t1x9gknd 7225 7 the the DT cord-010119-t1x9gknd 7225 8 A A NNP cord-010119-t1x9gknd 7225 9 allele allele NN cord-010119-t1x9gknd 7225 10 of of IN cord-010119-t1x9gknd 7225 11 rs1175550 rs1175550 NN cord-010119-t1x9gknd 7225 12 with with IN cord-010119-t1x9gknd 7225 13 reduction reduction NN cord-010119-t1x9gknd 7225 14 of of IN cord-010119-t1x9gknd 7225 15 Vel Vel NNP cord-010119-t1x9gknd 7225 16 expression expression NN cord-010119-t1x9gknd 7225 17 and and CC cord-010119-t1x9gknd 7225 18 suggests suggest VBZ cord-010119-t1x9gknd 7225 19 the the DT cord-010119-t1x9gknd 7225 20 involvement involvement NN cord-010119-t1x9gknd 7225 21 of of IN cord-010119-t1x9gknd 7225 22 a a DT cord-010119-t1x9gknd 7225 23 new new JJ cord-010119-t1x9gknd 7225 24 rs6673829 rs6673829 NN cord-010119-t1x9gknd 7225 25 change change NN cord-010119-t1x9gknd 7225 26 in in IN cord-010119-t1x9gknd 7225 27 Vel Vel NNP cord-010119-t1x9gknd 7225 28 expression expression NN cord-010119-t1x9gknd 7225 29 . . . cord-010119-t1x9gknd 7226 1 In in IN cord-010119-t1x9gknd 7226 2 conclusion conclusion NN cord-010119-t1x9gknd 7226 3 , , , cord-010119-t1x9gknd 7226 4 the the DT cord-010119-t1x9gknd 7226 5 several several JJ cord-010119-t1x9gknd 7226 6 patterns pattern NNS cord-010119-t1x9gknd 7226 7 of of IN cord-010119-t1x9gknd 7226 8 Vel Vel NNP cord-010119-t1x9gknd 7226 9 expression expression NN cord-010119-t1x9gknd 7226 10 found find VBN cord-010119-t1x9gknd 7226 11 in in IN cord-010119-t1x9gknd 7226 12 different different JJ cord-010119-t1x9gknd 7226 13 populations population NNS cord-010119-t1x9gknd 7226 14 can can MD cord-010119-t1x9gknd 7226 15 be be VB cord-010119-t1x9gknd 7226 16 influenced influence VBN cord-010119-t1x9gknd 7226 17 by by IN cord-010119-t1x9gknd 7226 18 different different JJ cord-010119-t1x9gknd 7226 19 molecular molecular JJ cord-010119-t1x9gknd 7226 20 changes change NNS cord-010119-t1x9gknd 7226 21 . . . cord-010119-t1x9gknd 7227 1 Background Background NNP cord-010119-t1x9gknd 7227 2 / / SYM cord-010119-t1x9gknd 7227 3 Case Case NNP cord-010119-t1x9gknd 7227 4 Studies Studies NNPS cord-010119-t1x9gknd 7227 5 : : : cord-010119-t1x9gknd 7227 6 The the DT cord-010119-t1x9gknd 7227 7 D D NNP cord-010119-t1x9gknd 7227 8 antigen antigen NN cord-010119-t1x9gknd 7227 9 is be VBZ cord-010119-t1x9gknd 7227 10 the the DT cord-010119-t1x9gknd 7227 11 most most RBS cord-010119-t1x9gknd 7227 12 immunogenic immunogenic JJ cord-010119-t1x9gknd 7227 13 antigen antigen NN cord-010119-t1x9gknd 7227 14 after after IN cord-010119-t1x9gknd 7227 15 ABO ABO NNP cord-010119-t1x9gknd 7227 16 . . . cord-010119-t1x9gknd 7228 1 Consequences consequence NNS cord-010119-t1x9gknd 7228 2 of of IN cord-010119-t1x9gknd 7228 3 misclassification misclassification NN cord-010119-t1x9gknd 7228 4 of of IN cord-010119-t1x9gknd 7228 5 the the DT cord-010119-t1x9gknd 7228 6 D d NN cord-010119-t1x9gknd 7228 7 - - HYPH cord-010119-t1x9gknd 7228 8 antigen antigen NN cord-010119-t1x9gknd 7228 9 in in IN cord-010119-t1x9gknd 7228 10 patients patient NNS cord-010119-t1x9gknd 7228 11 or or CC cord-010119-t1x9gknd 7228 12 donors donor NNS cord-010119-t1x9gknd 7228 13 can can MD cord-010119-t1x9gknd 7228 14 be be VB cord-010119-t1x9gknd 7228 15 severe severe JJ cord-010119-t1x9gknd 7228 16 . . . cord-010119-t1x9gknd 7229 1 Some some DT cord-010119-t1x9gknd 7229 2 persons person NNS cord-010119-t1x9gknd 7229 3 inherit inherit VBP cord-010119-t1x9gknd 7229 4 mutations mutation NNS cord-010119-t1x9gknd 7229 5 resulting result VBG cord-010119-t1x9gknd 7229 6 in in IN cord-010119-t1x9gknd 7229 7 quantitative quantitative JJ cord-010119-t1x9gknd 7229 8 reductions reduction NNS cord-010119-t1x9gknd 7229 9 of of IN cord-010119-t1x9gknd 7229 10 D d NN cord-010119-t1x9gknd 7229 11 antigen antigen NN cord-010119-t1x9gknd 7229 12 on on IN cord-010119-t1x9gknd 7229 13 the the DT cord-010119-t1x9gknd 7229 14 cell cell NN cord-010119-t1x9gknd 7229 15 surface surface NN cord-010119-t1x9gknd 7229 16 ( ( -LRB- cord-010119-t1x9gknd 7229 17 weak weak JJ cord-010119-t1x9gknd 7229 18 D D NNP cord-010119-t1x9gknd 7229 19 ) ) -RRB- cord-010119-t1x9gknd 7229 20 , , , cord-010119-t1x9gknd 7229 21 some some DT cord-010119-t1x9gknd 7229 22 inherit inherit VBP cord-010119-t1x9gknd 7229 23 Rh Rh NNP cord-010119-t1x9gknd 7229 24 haplotypes haplotype NNS cord-010119-t1x9gknd 7229 25 that that WDT cord-010119-t1x9gknd 7229 26 result result VBP cord-010119-t1x9gknd 7229 27 in in IN cord-010119-t1x9gknd 7229 28 biochemical biochemical JJ cord-010119-t1x9gknd 7229 29 effects effect NNS cord-010119-t1x9gknd 7229 30 that that WDT cord-010119-t1x9gknd 7229 31 reduce reduce VBP cord-010119-t1x9gknd 7229 32 the the DT cord-010119-t1x9gknd 7229 33 availability availability NN cord-010119-t1x9gknd 7229 34 of of IN cord-010119-t1x9gknd 7229 35 the the DT cord-010119-t1x9gknd 7229 36 D d NN cord-010119-t1x9gknd 7229 37 antigens antigen NNS cord-010119-t1x9gknd 7229 38 to to IN cord-010119-t1x9gknd 7229 39 reagent reagent JJ cord-010119-t1x9gknd 7229 40 anti anti JJ cord-010119-t1x9gknd 7229 41 - - JJ cord-010119-t1x9gknd 7229 42 sera sera JJ cord-010119-t1x9gknd 7229 43 ( ( -LRB- cord-010119-t1x9gknd 7229 44 Ceppellini Ceppellini NNP cord-010119-t1x9gknd 7229 45 effect effect NN cord-010119-t1x9gknd 7229 46 ) ) -RRB- cord-010119-t1x9gknd 7229 47 , , , cord-010119-t1x9gknd 7229 48 and and CC cord-010119-t1x9gknd 7229 49 others other NNS cord-010119-t1x9gknd 7229 50 inherit inherit VBP cord-010119-t1x9gknd 7229 51 D d NN cord-010119-t1x9gknd 7229 52 genes gene NNS cord-010119-t1x9gknd 7229 53 which which WDT cord-010119-t1x9gknd 7229 54 are be VBP cord-010119-t1x9gknd 7229 55 qualitatively qualitatively RB cord-010119-t1x9gknd 7229 56 different different JJ cord-010119-t1x9gknd 7229 57 than than IN cord-010119-t1x9gknd 7229 58 wild wild JJ cord-010119-t1x9gknd 7229 59 type type NN cord-010119-t1x9gknd 7229 60 D. D. NNP cord-010119-t1x9gknd 7230 1 These these DT cord-010119-t1x9gknd 7230 2 latter latter JJ cord-010119-t1x9gknd 7230 3 individuals individual NNS cord-010119-t1x9gknd 7230 4 are be VBP cord-010119-t1x9gknd 7230 5 often often RB cord-010119-t1x9gknd 7230 6 not not RB cord-010119-t1x9gknd 7230 7 identified identify VBN cord-010119-t1x9gknd 7230 8 until until IN cord-010119-t1x9gknd 7230 9 after after IN cord-010119-t1x9gknd 7230 10 they -PRON- PRP cord-010119-t1x9gknd 7230 11 have have VBP cord-010119-t1x9gknd 7230 12 formed form VBN cord-010119-t1x9gknd 7231 1 anti anti NNP cord-010119-t1x9gknd 7231 2 - - NNP cord-010119-t1x9gknd 7231 3 D. D. NNP cord-010119-t1x9gknd 7231 4 We -PRON- PRP cord-010119-t1x9gknd 7231 5 hypothesize hypothesize VBP cord-010119-t1x9gknd 7231 6 that that IN cord-010119-t1x9gknd 7231 7 some some DT cord-010119-t1x9gknd 7231 8 of of IN cord-010119-t1x9gknd 7231 9 these these DT cord-010119-t1x9gknd 7231 10 persons person NNS cord-010119-t1x9gknd 7231 11 at at IN cord-010119-t1x9gknd 7231 12 risk risk NN cord-010119-t1x9gknd 7231 13 of of IN cord-010119-t1x9gknd 7231 14 forming form VBG cord-010119-t1x9gknd 7231 15 anti anti JJ cord-010119-t1x9gknd 7231 16 - - JJ cord-010119-t1x9gknd 7231 17 D d JJ cord-010119-t1x9gknd 7231 18 might may MD cord-010119-t1x9gknd 7231 19 be be VB cord-010119-t1x9gknd 7231 20 uncovered uncover VBN cord-010119-t1x9gknd 7231 21 if if IN cord-010119-t1x9gknd 7231 22 they -PRON- PRP cord-010119-t1x9gknd 7231 23 have have VBP cord-010119-t1x9gknd 7231 24 weak weak JJ cord-010119-t1x9gknd 7231 25 and/or and/or CC cord-010119-t1x9gknd 7231 26 disparate disparate JJ cord-010119-t1x9gknd 7231 27 D d NN cord-010119-t1x9gknd 7231 28 typing typing NN cord-010119-t1x9gknd 7231 29 results result NNS cord-010119-t1x9gknd 7231 30 with with IN cord-010119-t1x9gknd 7231 31 reagents reagent NNS cord-010119-t1x9gknd 7231 32 that that WDT cord-010119-t1x9gknd 7231 33 recognize recognize VBP cord-010119-t1x9gknd 7231 34 different different JJ cord-010119-t1x9gknd 7231 35 epitopes epitope NNS cord-010119-t1x9gknd 7231 36 of of IN cord-010119-t1x9gknd 7231 37 the the DT cord-010119-t1x9gknd 7231 38 D D NNP cord-010119-t1x9gknd 7231 39 antigen antigen NN cord-010119-t1x9gknd 7231 40 . . . cord-010119-t1x9gknd 7232 1 Study Study NNP cord-010119-t1x9gknd 7232 2 Design Design NNP cord-010119-t1x9gknd 7232 3 / / SYM cord-010119-t1x9gknd 7232 4 Methods method NNS cord-010119-t1x9gknd 7232 5 : : : cord-010119-t1x9gknd 7232 6 All all DT cord-010119-t1x9gknd 7232 7 testing testing NN cord-010119-t1x9gknd 7232 8 was be VBD cord-010119-t1x9gknd 7232 9 performed perform VBN cord-010119-t1x9gknd 7232 10 using use VBG cord-010119-t1x9gknd 7232 11 microtiter microtiter NN cord-010119-t1x9gknd 7232 12 - - HYPH cord-010119-t1x9gknd 7232 13 well well RB cord-010119-t1x9gknd 7232 14 direct direct JJ cord-010119-t1x9gknd 7232 15 agglutination agglutination NN cord-010119-t1x9gknd 7232 16 on on IN cord-010119-t1x9gknd 7232 17 the the DT cord-010119-t1x9gknd 7232 18 GalileoNEO GalileoNEO NNP cord-010119-t1x9gknd 7232 19 or or CC cord-010119-t1x9gknd 7232 20 GalileoEcho GalileoEcho NNP cord-010119-t1x9gknd 7232 21 ( ( -LRB- cord-010119-t1x9gknd 7232 22 Immucor Immucor NNP cord-010119-t1x9gknd 7232 23 , , , cord-010119-t1x9gknd 7232 24 Norcross Norcross NNP cord-010119-t1x9gknd 7232 25 , , , cord-010119-t1x9gknd 7232 26 GA GA NNP cord-010119-t1x9gknd 7232 27 ) ) -RRB- cord-010119-t1x9gknd 7232 28 . . . cord-010119-t1x9gknd 7233 1 Any any DT cord-010119-t1x9gknd 7233 2 specimen specimen NN cord-010119-t1x9gknd 7233 3 that that WDT cord-010119-t1x9gknd 7233 4 did do VBD cord-010119-t1x9gknd 7233 5 not not RB cord-010119-t1x9gknd 7233 6 react react VB cord-010119-t1x9gknd 7233 7 as as IN cord-010119-t1x9gknd 7233 8 0 0 CD cord-010119-t1x9gknd 7233 9 ( ( -LRB- cord-010119-t1x9gknd 7233 10 Rh Rh NNP cord-010119-t1x9gknd 7233 11 Negative Negative NNP cord-010119-t1x9gknd 7233 12 ) ) -RRB- cord-010119-t1x9gknd 7233 13 , , , cord-010119-t1x9gknd 7233 14 or or CC cord-010119-t1x9gknd 7233 15 ! ! . cord-010119-t1x9gknd 7234 1 31 31 CD cord-010119-t1x9gknd 7234 2 on on IN cord-010119-t1x9gknd 7234 3 the the DT cord-010119-t1x9gknd 7234 4 NEO NEO NNP cord-010119-t1x9gknd 7234 5 or or CC cord-010119-t1x9gknd 7234 6 ! ! . cord-010119-t1x9gknd 7234 7 21 21 CD cord-010119-t1x9gknd 7234 8 on on IN cord-010119-t1x9gknd 7234 9 the the DT cord-010119-t1x9gknd 7234 10 Echo echo NN cord-010119-t1x9gknd 7234 11 ( ( -LRB- cord-010119-t1x9gknd 7234 12 Rh Rh NNP cord-010119-t1x9gknd 7234 13 Positive Positive NNP cord-010119-t1x9gknd 7234 14 ) ) -RRB- cord-010119-t1x9gknd 7234 15 for for IN cord-010119-t1x9gknd 7234 16 both both DT cord-010119-t1x9gknd 7234 17 series series NN cord-010119-t1x9gknd 7234 18 4 4 CD cord-010119-t1x9gknd 7234 19 and and CC cord-010119-t1x9gknd 7234 20 series series NNP cord-010119-t1x9gknd 7234 21 5 5 CD cord-010119-t1x9gknd 7234 22 anti anti JJ cord-010119-t1x9gknd 7234 23 - - JJ cord-010119-t1x9gknd 7234 24 D d JJ cord-010119-t1x9gknd 7234 25 antisera antisera NN cord-010119-t1x9gknd 7234 26 were be VBD cord-010119-t1x9gknd 7234 27 included include VBN cord-010119-t1x9gknd 7234 28 . . . cord-010119-t1x9gknd 7235 1 Patients patient NNS cord-010119-t1x9gknd 7235 2 with with IN cord-010119-t1x9gknd 7235 3 discrepant discrepant JJ cord-010119-t1x9gknd 7235 4 historical historical JJ cord-010119-t1x9gknd 7235 5 types type NNS cord-010119-t1x9gknd 7235 6 also also RB cord-010119-t1x9gknd 7235 7 were be VBD cord-010119-t1x9gknd 7235 8 evaluated evaluate VBN cord-010119-t1x9gknd 7235 9 . . . cord-010119-t1x9gknd 7236 1 Any any DT cord-010119-t1x9gknd 7236 2 specimens specimen NNS cord-010119-t1x9gknd 7236 3 meeting meet VBG cord-010119-t1x9gknd 7236 4 the the DT cord-010119-t1x9gknd 7236 5 inclusion inclusion NN cord-010119-t1x9gknd 7236 6 criteria criterion NNS cord-010119-t1x9gknd 7236 7 were be VBD cord-010119-t1x9gknd 7236 8 tested test VBN cord-010119-t1x9gknd 7236 9 on on IN cord-010119-t1x9gknd 7236 10 the the DT cord-010119-t1x9gknd 7236 11 NEO NEO NNP cord-010119-t1x9gknd 7236 12 , , , cord-010119-t1x9gknd 7236 13 Echo Echo NNP cord-010119-t1x9gknd 7236 14 , , , cord-010119-t1x9gknd 7236 15 and and CC cord-010119-t1x9gknd 7236 16 by by IN cord-010119-t1x9gknd 7236 17 saline saline NN cord-010119-t1x9gknd 7236 18 tube tube NN cord-010119-t1x9gknd 7236 19 method method NN cord-010119-t1x9gknd 7236 20 using use VBG cord-010119-t1x9gknd 7236 21 series series NN cord-010119-t1x9gknd 7236 22 4 4 CD cord-010119-t1x9gknd 7236 23 and and CC cord-010119-t1x9gknd 7236 24 series series NNP cord-010119-t1x9gknd 7236 25 5 5 CD cord-010119-t1x9gknd 7236 26 anti anti JJ cord-010119-t1x9gknd 7236 27 - - JJ cord-010119-t1x9gknd 7236 28 D d JJ cord-010119-t1x9gknd 7236 29 antisera antisera NN cord-010119-t1x9gknd 7236 30 . . . cord-010119-t1x9gknd 7237 1 Genotyping Genotyping NNP cord-010119-t1x9gknd 7237 2 was be VBD cord-010119-t1x9gknd 7237 3 performed perform VBN cord-010119-t1x9gknd 7237 4 from from IN cord-010119-t1x9gknd 7237 5 whole whole JJ cord-010119-t1x9gknd 7237 6 blood blood NN cord-010119-t1x9gknd 7237 7 samples sample NNS cord-010119-t1x9gknd 7237 8 sent send VBN cord-010119-t1x9gknd 7237 9 to to IN cord-010119-t1x9gknd 7237 10 Immucor Immucor NNP cord-010119-t1x9gknd 7237 11 genotyping genotype VBG cord-010119-t1x9gknd 7237 12 laboratory laboratory NN cord-010119-t1x9gknd 7237 13 in in IN cord-010119-t1x9gknd 7237 14 Warren Warren NNP cord-010119-t1x9gknd 7237 15 , , , cord-010119-t1x9gknd 7237 16 NJ NJ NNP cord-010119-t1x9gknd 7237 17 using use VBG cord-010119-t1x9gknd 7237 18 an an DT cord-010119-t1x9gknd 7237 19 algorithm algorithm NN cord-010119-t1x9gknd 7237 20 of of IN cord-010119-t1x9gknd 7237 21 : : : cord-010119-t1x9gknd 7237 22 RHD RHD NNP cord-010119-t1x9gknd 7237 23 BeadChip BeadChip NNP cord-010119-t1x9gknd 7237 24 , , , cord-010119-t1x9gknd 7237 25 RHDxp RHDxp NNP cord-010119-t1x9gknd 7237 26 ( ( -LRB- cord-010119-t1x9gknd 7237 27 prototype prototype NN cord-010119-t1x9gknd 7237 28 assay assay NN cord-010119-t1x9gknd 7237 29 ) ) -RRB- cord-010119-t1x9gknd 7237 30 , , , cord-010119-t1x9gknd 7237 31 RHD RHD NNP cord-010119-t1x9gknd 7237 32 zygosity zygosity NN cord-010119-t1x9gknd 7237 33 , , , cord-010119-t1x9gknd 7237 34 and and CC cord-010119-t1x9gknd 7237 35 RHCE RHCE NNP cord-010119-t1x9gknd 7237 36 BeadChip BeadChip NNP cord-010119-t1x9gknd 7237 37 . . . cord-010119-t1x9gknd 7238 1 Results/ Results/ . cord-010119-t1x9gknd 7239 1 Findings finding NNS cord-010119-t1x9gknd 7239 2 : : : cord-010119-t1x9gknd 7240 1 80 80 CD cord-010119-t1x9gknd 7240 2 patients patient NNS cord-010119-t1x9gknd 7240 3 met meet VBD cord-010119-t1x9gknd 7240 4 inclusion inclusion NN cord-010119-t1x9gknd 7240 5 criteria criterion NNS cord-010119-t1x9gknd 7240 6 for for IN cord-010119-t1x9gknd 7240 7 molecular molecular JJ cord-010119-t1x9gknd 7240 8 testing testing NN cord-010119-t1x9gknd 7240 9 for for IN cord-010119-t1x9gknd 7240 10 the the DT cord-010119-t1x9gknd 7240 11 D D NNP cord-010119-t1x9gknd 7240 12 antigen antigen NN cord-010119-t1x9gknd 7240 13 . . . cord-010119-t1x9gknd 7241 1 Weak weak JJ cord-010119-t1x9gknd 7241 2 or or CC cord-010119-t1x9gknd 7241 3 RhD rhd NN cord-010119-t1x9gknd 7241 4 variants variant NNS cord-010119-t1x9gknd 7241 5 were be VBD cord-010119-t1x9gknd 7241 6 identified identify VBN cord-010119-t1x9gknd 7241 7 in in IN cord-010119-t1x9gknd 7241 8 51 51 CD cord-010119-t1x9gknd 7241 9 of of IN cord-010119-t1x9gknd 7241 10 80 80 CD cord-010119-t1x9gknd 7241 11 ( ( -LRB- cord-010119-t1x9gknd 7241 12 63.7 63.7 CD cord-010119-t1x9gknd 7241 13 % % NN cord-010119-t1x9gknd 7241 14 ) ) -RRB- cord-010119-t1x9gknd 7241 15 of of IN cord-010119-t1x9gknd 7241 16 the the DT cord-010119-t1x9gknd 7241 17 samples sample NNS cord-010119-t1x9gknd 7241 18 . . . cord-010119-t1x9gknd 7242 1 Ceppellini Ceppellini NNP cord-010119-t1x9gknd 7242 2 effect effect NN cord-010119-t1x9gknd 7242 3 ( ( -LRB- cord-010119-t1x9gknd 7242 4 i.e. i.e. FW cord-010119-t1x9gknd 7242 5 C C NNP cord-010119-t1x9gknd 7242 6 in in IN cord-010119-t1x9gknd 7242 7 trans trans NNP cord-010119-t1x9gknd 7242 8 to to IN cord-010119-t1x9gknd 7242 9 RHD RHD NNP cord-010119-t1x9gknd 7242 10 ) ) -RRB- cord-010119-t1x9gknd 7242 11 resulting result VBG cord-010119-t1x9gknd 7242 12 in in IN cord-010119-t1x9gknd 7242 13 weak weak JJ cord-010119-t1x9gknd 7242 14 D d NN cord-010119-t1x9gknd 7242 15 reactivity reactivity NN cord-010119-t1x9gknd 7242 16 was be VBD cord-010119-t1x9gknd 7242 17 seen see VBN cord-010119-t1x9gknd 7242 18 in in IN cord-010119-t1x9gknd 7242 19 16 16 CD cord-010119-t1x9gknd 7242 20 of of IN cord-010119-t1x9gknd 7242 21 80 80 CD cord-010119-t1x9gknd 7242 22 ( ( -LRB- cord-010119-t1x9gknd 7242 23 20 20 CD cord-010119-t1x9gknd 7242 24 % % NN cord-010119-t1x9gknd 7242 25 ) ) -RRB- cord-010119-t1x9gknd 7242 26 of of IN cord-010119-t1x9gknd 7242 27 samples sample NNS cord-010119-t1x9gknd 7242 28 . . . cord-010119-t1x9gknd 7243 1 67 67 CD cord-010119-t1x9gknd 7243 2 of of IN cord-010119-t1x9gknd 7243 3 80 80 CD cord-010119-t1x9gknd 7243 4 ( ( -LRB- cord-010119-t1x9gknd 7243 5 83.8 83.8 CD cord-010119-t1x9gknd 7243 6 % % NN cord-010119-t1x9gknd 7243 7 ) ) -RRB- cord-010119-t1x9gknd 7243 8 of of IN cord-010119-t1x9gknd 7243 9 the the DT cord-010119-t1x9gknd 7243 10 samples sample NNS cord-010119-t1x9gknd 7243 11 that that WDT cord-010119-t1x9gknd 7243 12 resulted result VBD cord-010119-t1x9gknd 7243 13 in in IN cord-010119-t1x9gknd 7243 14 weak weak JJ cord-010119-t1x9gknd 7243 15 or or CC cord-010119-t1x9gknd 7243 16 discrepant discrepant JJ cord-010119-t1x9gknd 7243 17 reactivity reactivity NN cord-010119-t1x9gknd 7243 18 had have VBD cord-010119-t1x9gknd 7243 19 some some DT cord-010119-t1x9gknd 7243 20 type type NN cord-010119-t1x9gknd 7243 21 of of IN cord-010119-t1x9gknd 7243 22 genetic genetic JJ cord-010119-t1x9gknd 7243 23 cause cause NN cord-010119-t1x9gknd 7243 24 that that WDT cord-010119-t1x9gknd 7243 25 was be VBD cord-010119-t1x9gknd 7243 26 resolved resolve VBN cord-010119-t1x9gknd 7243 27 by by IN cord-010119-t1x9gknd 7243 28 using use VBG cord-010119-t1x9gknd 7243 29 our -PRON- PRP$ cord-010119-t1x9gknd 7243 30 algorithm algorithm NN cord-010119-t1x9gknd 7243 31 . . . cord-010119-t1x9gknd 7244 1 40 40 CD cord-010119-t1x9gknd 7244 2 of of IN cord-010119-t1x9gknd 7244 3 80 80 CD cord-010119-t1x9gknd 7244 4 ( ( -LRB- cord-010119-t1x9gknd 7244 5 50 50 CD cord-010119-t1x9gknd 7244 6 % % NN cord-010119-t1x9gknd 7244 7 ) ) -RRB- cord-010119-t1x9gknd 7244 8 of of IN cord-010119-t1x9gknd 7244 9 tested test VBN cord-010119-t1x9gknd 7244 10 samples sample NNS cord-010119-t1x9gknd 7244 11 had have VBD cord-010119-t1x9gknd 7244 12 results result NNS cord-010119-t1x9gknd 7244 13 indicating indicate VBG cord-010119-t1x9gknd 7244 14 weak weak JJ cord-010119-t1x9gknd 7244 15 / / SYM cord-010119-t1x9gknd 7244 16 variant variant NN cord-010119-t1x9gknd 7244 17 D d NN cord-010119-t1x9gknd 7244 18 proteins protein NNS cord-010119-t1x9gknd 7244 19 with with IN cord-010119-t1x9gknd 7244 20 the the DT cord-010119-t1x9gknd 7244 21 potential potential NN cord-010119-t1x9gknd 7244 22 to to TO cord-010119-t1x9gknd 7244 23 cause cause VB cord-010119-t1x9gknd 7244 24 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7244 25 to to IN cord-010119-t1x9gknd 7244 26 the the DT cord-010119-t1x9gknd 7244 27 D D NNP cord-010119-t1x9gknd 7244 28 antigen antigen NN cord-010119-t1x9gknd 7244 29 . . . cord-010119-t1x9gknd 7245 1 The the DT cord-010119-t1x9gknd 7245 2 remaining remain VBG cord-010119-t1x9gknd 7245 3 13 13 CD cord-010119-t1x9gknd 7245 4 of of IN cord-010119-t1x9gknd 7245 5 80 80 CD cord-010119-t1x9gknd 7245 6 ( ( -LRB- cord-010119-t1x9gknd 7245 7 17.3 17.3 CD cord-010119-t1x9gknd 7245 8 % % NN cord-010119-t1x9gknd 7245 9 ) ) -RRB- cord-010119-t1x9gknd 7246 1 samples sample NNS cord-010119-t1x9gknd 7246 2 did do VBD cord-010119-t1x9gknd 7246 3 not not RB cord-010119-t1x9gknd 7246 4 have have VB cord-010119-t1x9gknd 7246 5 identified identify VBN cord-010119-t1x9gknd 7246 6 genetic genetic JJ cord-010119-t1x9gknd 7246 7 cause cause NN cord-010119-t1x9gknd 7246 8 for for IN cord-010119-t1x9gknd 7246 9 the the DT cord-010119-t1x9gknd 7246 10 weak weak JJ cord-010119-t1x9gknd 7246 11 and/or and/or CC cord-010119-t1x9gknd 7246 12 discrepant discrepant JJ cord-010119-t1x9gknd 7246 13 D d NN cord-010119-t1x9gknd 7246 14 test test NN cord-010119-t1x9gknd 7246 15 results result NNS cord-010119-t1x9gknd 7246 16 and and CC cord-010119-t1x9gknd 7246 17 were be VBD cord-010119-t1x9gknd 7246 18 presumptively presumptively RB cord-010119-t1x9gknd 7246 19 classified classify VBN cord-010119-t1x9gknd 7246 20 as as IN cord-010119-t1x9gknd 7246 21 wild wild JJ cord-010119-t1x9gknd 7246 22 type type NN cord-010119-t1x9gknd 7246 23 D. D. NNP cord-010119-t1x9gknd 7246 24 Conclusion Conclusion NNP cord-010119-t1x9gknd 7246 25 : : : cord-010119-t1x9gknd 7246 26 Transfusion transfusion NN cord-010119-t1x9gknd 7246 27 services service NNS cord-010119-t1x9gknd 7246 28 that that WDT cord-010119-t1x9gknd 7246 29 use use VBP cord-010119-t1x9gknd 7246 30 the the DT cord-010119-t1x9gknd 7246 31 GalileoNEO GalileoNEO NNP cord-010119-t1x9gknd 7246 32 or or CC cord-010119-t1x9gknd 7246 33 GalileoEcho GalileoEcho NNP cord-010119-t1x9gknd 7246 34 to to TO cord-010119-t1x9gknd 7246 35 perform perform VB cord-010119-t1x9gknd 7246 36 Rh Rh NNP cord-010119-t1x9gknd 7246 37 typing typing NN cord-010119-t1x9gknd 7246 38 should should MD cord-010119-t1x9gknd 7246 39 consider consider VB cord-010119-t1x9gknd 7246 40 molecular molecular JJ cord-010119-t1x9gknd 7246 41 testing testing NN cord-010119-t1x9gknd 7246 42 of of IN cord-010119-t1x9gknd 7246 43 patients patient NNS cord-010119-t1x9gknd 7246 44 whose whose WP$ cord-010119-t1x9gknd 7246 45 Rh Rh NNP cord-010119-t1x9gknd 7246 46 typing typing NN cord-010119-t1x9gknd 7246 47 results result NNS cord-010119-t1x9gknd 7246 48 are be VBP cord-010119-t1x9gknd 7246 49 discrepant discrepant JJ cord-010119-t1x9gknd 7246 50 , , , cord-010119-t1x9gknd 7246 51 or or CC cord-010119-t1x9gknd 7246 52 positive positive JJ cord-010119-t1x9gknd 7246 53 but but CC cord-010119-t1x9gknd 7246 54 < < XX cord-010119-t1x9gknd 7246 55 31 31 CD cord-010119-t1x9gknd 7246 56 on on IN cord-010119-t1x9gknd 7246 57 the the DT cord-010119-t1x9gknd 7246 58 GalileoNEO GalileoNEO NNP cord-010119-t1x9gknd 7246 59 or or CC cord-010119-t1x9gknd 7246 60 positive positive JJ cord-010119-t1x9gknd 7246 61 but but CC cord-010119-t1x9gknd 7246 62 < < XX cord-010119-t1x9gknd 7246 63 21 21 CD cord-010119-t1x9gknd 7246 64 on on IN cord-010119-t1x9gknd 7246 65 the the DT cord-010119-t1x9gknd 7246 66 GalileoEcho GalileoEcho NNP cord-010119-t1x9gknd 7246 67 , , , cord-010119-t1x9gknd 7246 68 as as IN cord-010119-t1x9gknd 7246 69 about about IN cord-010119-t1x9gknd 7246 70 half half NN cord-010119-t1x9gknd 7246 71 of of IN cord-010119-t1x9gknd 7246 72 these these DT cord-010119-t1x9gknd 7246 73 patients patient NNS cord-010119-t1x9gknd 7246 74 can can MD cord-010119-t1x9gknd 7246 75 develop develop VB cord-010119-t1x9gknd 7246 76 anti anti JJ cord-010119-t1x9gknd 7246 77 - - JJ cord-010119-t1x9gknd 7246 78 D. D. NNP cord-010119-t1x9gknd 7246 79 This this DT cord-010119-t1x9gknd 7246 80 is be VBZ cord-010119-t1x9gknd 7246 81 particularly particularly RB cord-010119-t1x9gknd 7246 82 relevant relevant JJ cord-010119-t1x9gknd 7246 83 for for IN cord-010119-t1x9gknd 7246 84 females female NNS cord-010119-t1x9gknd 7246 85 of of IN cord-010119-t1x9gknd 7246 86 child child NN cord-010119-t1x9gknd 7246 87 - - HYPH cord-010119-t1x9gknd 7246 88 bearing bear VBG cord-010119-t1x9gknd 7246 89 potential potential NN cord-010119-t1x9gknd 7246 90 where where WRB cord-010119-t1x9gknd 7246 91 avoidance avoidance NN cord-010119-t1x9gknd 7246 92 of of IN cord-010119-t1x9gknd 7246 93 D d NN cord-010119-t1x9gknd 7246 94 - - HYPH cord-010119-t1x9gknd 7246 95 positive positive JJ cord-010119-t1x9gknd 7246 96 transfusions transfusion NNS cord-010119-t1x9gknd 7246 97 and and CC cord-010119-t1x9gknd 7246 98 administration administration NN cord-010119-t1x9gknd 7246 99 of of IN cord-010119-t1x9gknd 7246 100 RhIg RhIg NNP cord-010119-t1x9gknd 7246 101 during during IN cord-010119-t1x9gknd 7246 102 pregnancy pregnancy NN cord-010119-t1x9gknd 7246 103 is be VBZ cord-010119-t1x9gknd 7246 104 prudent prudent JJ cord-010119-t1x9gknd 7246 105 until until IN cord-010119-t1x9gknd 7246 106 their -PRON- PRP$ cord-010119-t1x9gknd 7246 107 D d NN cord-010119-t1x9gknd 7246 108 typing typing NN cord-010119-t1x9gknd 7246 109 can can MD cord-010119-t1x9gknd 7246 110 be be VB cord-010119-t1x9gknd 7246 111 confirmed confirm VBN cord-010119-t1x9gknd 7246 112 by by IN cord-010119-t1x9gknd 7246 113 molecular molecular JJ cord-010119-t1x9gknd 7246 114 testing testing NN cord-010119-t1x9gknd 7246 115 . . . cord-010119-t1x9gknd 7247 1 Carine Carine NNP cord-010119-t1x9gknd 7247 2 Arnoni Arnoni NNP cord-010119-t1x9gknd 7247 3 * * NFP cord-010119-t1x9gknd 7247 4 1 1 CD cord-010119-t1x9gknd 7247 5 , , , cord-010119-t1x9gknd 7247 6 Tatiane Tatiane NNP cord-010119-t1x9gknd 7247 7 Vendrame Vendrame NNP cord-010119-t1x9gknd 7247 8 2 2 CD cord-010119-t1x9gknd 7247 9 , , , cord-010119-t1x9gknd 7247 10 Janaína Janaína NNP cord-010119-t1x9gknd 7247 11 Muniz Muniz NNP cord-010119-t1x9gknd 7247 12 3 3 CD cord-010119-t1x9gknd 7247 13 , , , cord-010119-t1x9gknd 7247 14 Rosangela Rosangela NNP cord-010119-t1x9gknd 7247 15 Person Person NNP cord-010119-t1x9gknd 7247 16 2 2 CD cord-010119-t1x9gknd 7247 17 , , , cord-010119-t1x9gknd 7247 18 Lilian Lilian NNP cord-010119-t1x9gknd 7247 19 Castilho Castilho NNP cord-010119-t1x9gknd 7247 20 4 4 CD cord-010119-t1x9gknd 7247 21 , , , cord-010119-t1x9gknd 7247 22 Afonso Afonso NNP cord-010119-t1x9gknd 7247 23 Cortez Cortez NNP cord-010119-t1x9gknd 7247 24 2 2 CD cord-010119-t1x9gknd 7247 25 and and CC cord-010119-t1x9gknd 7247 26 Flavia Flavia NNP cord-010119-t1x9gknd 7247 27 Latini Latini NNP cord-010119-t1x9gknd 7247 28 2 2 CD cord-010119-t1x9gknd 7247 29 . . . cord-010119-t1x9gknd 7248 1 1 1 CD cord-010119-t1x9gknd 7248 2 Associa Associa NNP cord-010119-t1x9gknd 7248 3 , , , cord-010119-t1x9gknd 7248 4 2 2 CD cord-010119-t1x9gknd 7248 5 Associac¸ão associac¸ão NN cord-010119-t1x9gknd 7248 6 Beneficente Beneficente NNP cord-010119-t1x9gknd 7248 7 de de NNP cord-010119-t1x9gknd 7248 8 Coleta Coleta NNP cord-010119-t1x9gknd 7248 9 de de NNP cord-010119-t1x9gknd 7248 10 Sangue Sangue NNP cord-010119-t1x9gknd 7248 11 , , , cord-010119-t1x9gknd 7248 12 3 3 CD cord-010119-t1x9gknd 7248 13 Hemocentro Hemocentro NNP cord-010119-t1x9gknd 7248 14 de de NNP cord-010119-t1x9gknd 7248 15 São São NNP cord-010119-t1x9gknd 7248 16 Jos Jos NNP cord-010119-t1x9gknd 7248 17 e e NNP cord-010119-t1x9gknd 7248 18 do do VBP cord-010119-t1x9gknd 7248 19 Rio Rio NNP cord-010119-t1x9gknd 7248 20 Preto Preto NNP cord-010119-t1x9gknd 7248 21 , , , cord-010119-t1x9gknd 7248 22 4 4 CD cord-010119-t1x9gknd 7248 23 Hemocentro Hemocentro NNP cord-010119-t1x9gknd 7248 24 Unicamp Unicamp NNP cord-010119-t1x9gknd 7248 25 Background Background NNP cord-010119-t1x9gknd 7248 26 / / SYM cord-010119-t1x9gknd 7248 27 Case Case NNP cord-010119-t1x9gknd 7248 28 Studies Studies NNPS cord-010119-t1x9gknd 7248 29 : : : cord-010119-t1x9gknd 7248 30 RhD RhD NNP cord-010119-t1x9gknd 7248 31 and and CC cord-010119-t1x9gknd 7248 32 RhCE RhCE NNP cord-010119-t1x9gknd 7248 33 , , , cord-010119-t1x9gknd 7248 34 are be VBP cord-010119-t1x9gknd 7248 35 major major JJ cord-010119-t1x9gknd 7248 36 protein protein NN cord-010119-t1x9gknd 7248 37 constituents constituent NNS cord-010119-t1x9gknd 7248 38 of of IN cord-010119-t1x9gknd 7248 39 red red JJ cord-010119-t1x9gknd 7248 40 blood blood NN cord-010119-t1x9gknd 7248 41 cell cell NN cord-010119-t1x9gknd 7248 42 membrane membrane NN cord-010119-t1x9gknd 7248 43 , , , cord-010119-t1x9gknd 7248 44 composing compose VBG cord-010119-t1x9gknd 7248 45 a a DT cord-010119-t1x9gknd 7248 46 complex complex NN cord-010119-t1x9gknd 7248 47 together together RB cord-010119-t1x9gknd 7248 48 with with IN cord-010119-t1x9gknd 7248 49 RhAG rhag NN cord-010119-t1x9gknd 7248 50 . . . cord-010119-t1x9gknd 7249 1 Many many JJ cord-010119-t1x9gknd 7249 2 variant variant NN cord-010119-t1x9gknd 7249 3 Rh Rh NNP cord-010119-t1x9gknd 7249 4 proteins protein NNS cord-010119-t1x9gknd 7249 5 have have VBP cord-010119-t1x9gknd 7249 6 been be VBN cord-010119-t1x9gknd 7249 7 described describe VBN cord-010119-t1x9gknd 7249 8 and and CC cord-010119-t1x9gknd 7249 9 most most JJS cord-010119-t1x9gknd 7249 10 of of IN cord-010119-t1x9gknd 7249 11 them -PRON- PRP cord-010119-t1x9gknd 7249 12 affect affect VBP cord-010119-t1x9gknd 7249 13 the the DT cord-010119-t1x9gknd 7249 14 integration integration NN cord-010119-t1x9gknd 7249 15 of of IN cord-010119-t1x9gknd 7249 16 Rh Rh NNP cord-010119-t1x9gknd 7249 17 proteins protein NNS cord-010119-t1x9gknd 7249 18 in in IN cord-010119-t1x9gknd 7249 19 the the DT cord-010119-t1x9gknd 7249 20 membrane membrane NN cord-010119-t1x9gknd 7249 21 . . . cord-010119-t1x9gknd 7250 1 D D NNP cord-010119-t1x9gknd 7250 2 antigen antigen NN cord-010119-t1x9gknd 7250 3 expression expression NN cord-010119-t1x9gknd 7250 4 can can MD cord-010119-t1x9gknd 7250 5 be be VB cord-010119-t1x9gknd 7250 6 affected affect VBN cord-010119-t1x9gknd 7250 7 by by IN cord-010119-t1x9gknd 7250 8 several several JJ cord-010119-t1x9gknd 7250 9 molecular molecular JJ cord-010119-t1x9gknd 7250 10 changes change NNS cord-010119-t1x9gknd 7250 11 and and CC cord-010119-t1x9gknd 7250 12 also also RB cord-010119-t1x9gknd 7250 13 by by IN cord-010119-t1x9gknd 7250 14 the the DT cord-010119-t1x9gknd 7250 15 RHCEhaplotypes rhcehaplotype NNS cord-010119-t1x9gknd 7250 16 . . . cord-010119-t1x9gknd 7251 1 The the DT cord-010119-t1x9gknd 7251 2 present present JJ cord-010119-t1x9gknd 7251 3 study study NN cord-010119-t1x9gknd 7251 4 investigated investigate VBD cord-010119-t1x9gknd 7251 5 the the DT cord-010119-t1x9gknd 7251 6 score score NN cord-010119-t1x9gknd 7251 7 of of IN cord-010119-t1x9gknd 7251 8 reactivity reactivity NN cord-010119-t1x9gknd 7251 9 of of IN cord-010119-t1x9gknd 7251 10 samples sample NNS cord-010119-t1x9gknd 7251 11 presenting present VBG cord-010119-t1x9gknd 7251 12 a a DT cord-010119-t1x9gknd 7251 13 strong strong JJ cord-010119-t1x9gknd 7251 14 reduction reduction NN cord-010119-t1x9gknd 7251 15 in in IN cord-010119-t1x9gknd 7251 16 D d NN cord-010119-t1x9gknd 7251 17 expression expression NN cord-010119-t1x9gknd 7251 18 . . . cord-010119-t1x9gknd 7252 1 Study Study NNP cord-010119-t1x9gknd 7252 2 Design Design NNP cord-010119-t1x9gknd 7252 3 / / SYM cord-010119-t1x9gknd 7252 4 Method method NN cord-010119-t1x9gknd 7252 5 : : : cord-010119-t1x9gknd 7253 1 A a DT cord-010119-t1x9gknd 7253 2 total total NN cord-010119-t1x9gknd 7253 3 of of IN cord-010119-t1x9gknd 7253 4 108 108 CD cord-010119-t1x9gknd 7253 5 samples sample NNS cord-010119-t1x9gknd 7253 6 were be VBD cord-010119-t1x9gknd 7253 7 included include VBN cord-010119-t1x9gknd 7253 8 in in IN cord-010119-t1x9gknd 7253 9 the the DT cord-010119-t1x9gknd 7253 10 study study NN cord-010119-t1x9gknd 7253 11 , , , cord-010119-t1x9gknd 7253 12 being be VBG cord-010119-t1x9gknd 7253 13 69 69 CD cord-010119-t1x9gknd 7253 14 previously previously RB cord-010119-t1x9gknd 7253 15 genotyped genotype VBN cord-010119-t1x9gknd 7253 16 as as IN cord-010119-t1x9gknd 7253 17 RHD*DAR1.2 RHD*DAR1.2 NNP cord-010119-t1x9gknd 7253 18 , , , cord-010119-t1x9gknd 7253 19 37 37 CD cord-010119-t1x9gknd 7253 20 RHD*DAR3.1 RHD*DAR3.1 NNP cord-010119-t1x9gknd 7253 21 and and CC cord-010119-t1x9gknd 7253 22 2 2 CD cord-010119-t1x9gknd 7253 23 RHD*DAU6 rhd*dau6 NN cord-010119-t1x9gknd 7253 24 . . . cord-010119-t1x9gknd 7254 1 The the DT cord-010119-t1x9gknd 7254 2 samples sample NNS cord-010119-t1x9gknd 7254 3 were be VBD cord-010119-t1x9gknd 7254 4 phenotyped phenotype VBN cord-010119-t1x9gknd 7254 5 in in IN cord-010119-t1x9gknd 7254 6 NeoV NeoV NNP cord-010119-t1x9gknd 7254 7 R r NN cord-010119-t1x9gknd 7254 8 ( ( -LRB- cord-010119-t1x9gknd 7254 9 Immucor Immucor NNP cord-010119-t1x9gknd 7254 10 ) ) -RRB- cord-010119-t1x9gknd 7254 11 to to IN cord-010119-t1x9gknd 7254 12 D D NNP cord-010119-t1x9gknd 7254 13 , , , cord-010119-t1x9gknd 7254 14 C C NNP cord-010119-t1x9gknd 7254 15 / / SYM cord-010119-t1x9gknd 7254 16 c c NN cord-010119-t1x9gknd 7254 17 and and CC cord-010119-t1x9gknd 7254 18 E e NN cord-010119-t1x9gknd 7254 19 / / SYM cord-010119-t1x9gknd 7254 20 e e NN cord-010119-t1x9gknd 7254 21 antigens antigen NNS cord-010119-t1x9gknd 7254 22 by by IN cord-010119-t1x9gknd 7254 23 direct direct JJ cord-010119-t1x9gknd 7254 24 agglutinationin agglutinationin NNP cord-010119-t1x9gknd 7254 25 microplate microplate NN cord-010119-t1x9gknd 7254 26 . . . cord-010119-t1x9gknd 7255 1 Results result NNS cord-010119-t1x9gknd 7255 2 obtained obtain VBN cord-010119-t1x9gknd 7255 3 in in IN cord-010119-t1x9gknd 7255 4 NeoV NeoV NNP cord-010119-t1x9gknd 7255 5 R R NNS cord-010119-t1x9gknd 7255 6 were be VBD cord-010119-t1x9gknd 7255 7 expressed express VBN cord-010119-t1x9gknd 7255 8 in in IN cord-010119-t1x9gknd 7255 9 a a DT cord-010119-t1x9gknd 7255 10 score score NN cord-010119-t1x9gknd 7255 11 from from IN cord-010119-t1x9gknd 7255 12 0 0 CD cord-010119-t1x9gknd 7255 13 -99 -99 NN cord-010119-t1x9gknd 7255 14 corresponding correspond VBG cord-010119-t1x9gknd 7255 15 to to IN cord-010119-t1x9gknd 7255 16 the the DT cord-010119-t1x9gknd 7255 17 reaction reaction NN cord-010119-t1x9gknd 7255 18 intensity intensity NN cord-010119-t1x9gknd 7255 19 . . . cord-010119-t1x9gknd 7256 1 Zygosity zygosity NN cord-010119-t1x9gknd 7256 2 assay assay NN cord-010119-t1x9gknd 7256 3 was be VBD cord-010119-t1x9gknd 7256 4 performed perform VBN cord-010119-t1x9gknd 7256 5 by by IN cord-010119-t1x9gknd 7256 6 a a DT cord-010119-t1x9gknd 7256 7 multiplex multiplex JJ cord-010119-t1x9gknd 7256 8 real real JJ cord-010119-t1x9gknd 7256 9 - - HYPH cord-010119-t1x9gknd 7256 10 time time NN cord-010119-t1x9gknd 7256 11 quantitative quantitative JJ cord-010119-t1x9gknd 7256 12 PCR PCR NNP cord-010119-t1x9gknd 7256 13 using use VBG cord-010119-t1x9gknd 7256 14 a a DT cord-010119-t1x9gknd 7256 15 set set NN cord-010119-t1x9gknd 7256 16 of of IN cord-010119-t1x9gknd 7256 17 RHD rhd NN cord-010119-t1x9gknd 7256 18 - - HYPH cord-010119-t1x9gknd 7256 19 specific specific JJ cord-010119-t1x9gknd 7256 20 primers primer NNS cord-010119-t1x9gknd 7256 21 in in IN cord-010119-t1x9gknd 7256 22 RHD RHD NNP cord-010119-t1x9gknd 7256 23 exon exon NN cord-010119-t1x9gknd 7256 24 10 10 CD cord-010119-t1x9gknd 7256 25 . . . cord-010119-t1x9gknd 7257 1 RHCE RHCE NNP cord-010119-t1x9gknd 7257 2 genotyping genotyping NN cord-010119-t1x9gknd 7257 3 was be VBD cord-010119-t1x9gknd 7257 4 performed perform VBN cord-010119-t1x9gknd 7257 5 by by IN cord-010119-t1x9gknd 7257 6 PCR PCR NNP cord-010119-t1x9gknd 7257 7 - - HYPH cord-010119-t1x9gknd 7257 8 RFLP RFLP NNP cord-010119-t1x9gknd 7257 9 and and CC cord-010119-t1x9gknd 7257 10 SSP SSP NNP cord-010119-t1x9gknd 7257 11 - - HYPH cord-010119-t1x9gknd 7257 12 PCR PCR NNP cord-010119-t1x9gknd 7257 13 . . . cord-010119-t1x9gknd 7258 1 The the DT cord-010119-t1x9gknd 7258 2 presence presence NN cord-010119-t1x9gknd 7258 3 of of IN cord-010119-t1x9gknd 7258 4 a a DT cord-010119-t1x9gknd 7258 5 D D NNP cord-010119-t1x9gknd 7258 6 - - HYPH cord-010119-t1x9gknd 7258 7 CEhybridexon CEhybridexon NNP cord-010119-t1x9gknd 7258 8 3 3 CD cord-010119-t1x9gknd 7258 9 was be VBD cord-010119-t1x9gknd 7258 10 identified identify VBN cord-010119-t1x9gknd 7258 11 by by IN cord-010119-t1x9gknd 7258 12 amultiplex amultiplex NNP cord-010119-t1x9gknd 7258 13 PCR PCR NNP cord-010119-t1x9gknd 7258 14 . . . cord-010119-t1x9gknd 7259 1 Sequencing sequencing NN cord-010119-t1x9gknd 7259 2 and and CC cord-010119-t1x9gknd 7259 3 identification identification NN cord-010119-t1x9gknd 7259 4 of of IN cord-010119-t1x9gknd 7259 5 RHCE RHCE NNP cord-010119-t1x9gknd 7259 6 variants variant NNS cord-010119-t1x9gknd 7259 7 were be VBD cord-010119-t1x9gknd 7259 8 also also RB cord-010119-t1x9gknd 7259 9 performed perform VBN cord-010119-t1x9gknd 7259 10 when when WRB cord-010119-t1x9gknd 7259 11 necessary necessary JJ cord-010119-t1x9gknd 7259 12 . . . cord-010119-t1x9gknd 7260 1 Results/ Results/ . cord-010119-t1x9gknd 7261 1 Finding finding NN cord-010119-t1x9gknd 7261 2 : : : cord-010119-t1x9gknd 7262 1 Zygosity Zygosity NNP cord-010119-t1x9gknd 7262 2 results result NNS cord-010119-t1x9gknd 7262 3 showed show VBD cord-010119-t1x9gknd 7262 4 that that IN cord-010119-t1x9gknd 7262 5 10 10 CD cord-010119-t1x9gknd 7262 6 of of IN cord-010119-t1x9gknd 7262 7 108 108 CD cord-010119-t1x9gknd 7262 8 samples sample NNS cord-010119-t1x9gknd 7262 9 ( ( -LRB- cord-010119-t1x9gknd 7262 10 5 5 CD cord-010119-t1x9gknd 7262 11 DAR1.2 DAR1.2 NNP cord-010119-t1x9gknd 7262 12 , , , cord-010119-t1x9gknd 7262 13 4 4 CD cord-010119-t1x9gknd 7262 14 DAR3.1 DAR3.1 NNP cord-010119-t1x9gknd 7262 15 and and CC cord-010119-t1x9gknd 7262 16 1 1 CD cord-010119-t1x9gknd 7262 17 DAU6 DAU6 NNP cord-010119-t1x9gknd 7262 18 ) ) -RRB- cord-010119-t1x9gknd 7262 19 had have VBD cord-010119-t1x9gknd 7262 20 2 2 CD cord-010119-t1x9gknd 7262 21 RHD RHD NNP cord-010119-t1x9gknd 7262 22 genes gene NNS cord-010119-t1x9gknd 7262 23 , , , cord-010119-t1x9gknd 7262 24 were be VBD cord-010119-t1x9gknd 7262 25 phenotyped phenotype VBN cord-010119-t1x9gknd 7262 26 as as IN cord-010119-t1x9gknd 7262 27 C1E c1e NN cord-010119-t1x9gknd 7262 28 - - HYPH cord-010119-t1x9gknd 7262 29 c1e1 c1e1 NN cord-010119-t1x9gknd 7262 30 and and CC cord-010119-t1x9gknd 7262 31 genotyped genotype VBN cord-010119-t1x9gknd 7262 32 as as IN cord-010119-t1x9gknd 7262 33 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 7262 34 / / SYM cord-010119-t1x9gknd 7262 35 RHCEce RHCEce NNS cord-010119-t1x9gknd 7262 36 . . . cord-010119-t1x9gknd 7263 1 RHD RHD NNP cord-010119-t1x9gknd 7263 2 and and CC cord-010119-t1x9gknd 7263 3 RHCE RHCE NNP cord-010119-t1x9gknd 7263 4 genotyping genotype VBG cord-010119-t1x9gknd 7263 5 in in IN cord-010119-t1x9gknd 7263 6 these these DT cord-010119-t1x9gknd 7263 7 10 10 CD cord-010119-t1x9gknd 7263 8 samples sample NNS cord-010119-t1x9gknd 7263 9 showed show VBD cord-010119-t1x9gknd 7263 10 the the DT cord-010119-t1x9gknd 7263 11 presence presence NN cord-010119-t1x9gknd 7263 12 of of IN cord-010119-t1x9gknd 7263 13 the the DT cord-010119-t1x9gknd 7263 14 D D NNP cord-010119-t1x9gknd 7263 15 - - HYPH cord-010119-t1x9gknd 7263 16 CE CE NNP cord-010119-t1x9gknd 7263 17 - - HYPH cord-010119-t1x9gknd 7263 18 D D NNP cord-010119-t1x9gknd 7263 19 S S NNP cord-010119-t1x9gknd 7263 20 hybrid hybrid NN cord-010119-t1x9gknd 7263 21 gene gene NN cord-010119-t1x9gknd 7263 22 . . . cord-010119-t1x9gknd 7264 1 RHCE RHCE NNP cord-010119-t1x9gknd 7264 2 variants variant NNS cord-010119-t1x9gknd 7264 3 investigated investigate VBN cord-010119-t1x9gknd 7264 4 in in IN cord-010119-t1x9gknd 7264 5 2 2 CD cord-010119-t1x9gknd 7264 6 DAR1.2 DAR1.2 NNP cord-010119-t1x9gknd 7264 7 samples sample NNS cord-010119-t1x9gknd 7264 8 showed show VBD cord-010119-t1x9gknd 7264 9 the the DT cord-010119-t1x9gknd 7264 10 RHCE*-ceAR RHCE*-ceAR NNP cord-010119-t1x9gknd 7264 11 / / SYM cord-010119-t1x9gknd 7264 12 ce ce NNP cord-010119-t1x9gknd 7264 13 S S NNP cord-010119-t1x9gknd 7264 14 genotype genotype NN cord-010119-t1x9gknd 7264 15 , , , cord-010119-t1x9gknd 7264 16 in in IN cord-010119-t1x9gknd 7264 17 2 2 CD cord-010119-t1x9gknd 7265 1 DAR3.1 DAR3.1 NNP cord-010119-t1x9gknd 7265 2 samples sample VBZ cord-010119-t1x9gknd 7265 3 the the DT cord-010119-t1x9gknd 7266 1 RHCE*ceVS.02 RHCE*ceVS.02 NNP cord-010119-t1x9gknd 7266 2 / / SYM cord-010119-t1x9gknd 7266 3 ce ce NNP cord-010119-t1x9gknd 7266 4 S S NNP cord-010119-t1x9gknd 7266 5 genotype genotype NN cord-010119-t1x9gknd 7266 6 and and CC cord-010119-t1x9gknd 7266 7 in in IN cord-010119-t1x9gknd 7266 8 the the DT cord-010119-t1x9gknd 7266 9 DAU6 DAU6 NNP cord-010119-t1x9gknd 7266 10 sample sample NN cord-010119-t1x9gknd 7266 11 the the DT cord-010119-t1x9gknd 7266 12 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 7266 13 S S NNP cord-010119-t1x9gknd 7267 1 /ce /ce . cord-010119-t1x9gknd 7267 2 genotype genotype NNP cord-010119-t1x9gknd 7267 3 . . . cord-010119-t1x9gknd 7268 1 Table table NN cord-010119-t1x9gknd 7268 2 1 1 CD cord-010119-t1x9gknd 7268 3 describes describe VBZ cord-010119-t1x9gknd 7268 4 the the DT cord-010119-t1x9gknd 7268 5 differences difference NNS cord-010119-t1x9gknd 7268 6 found find VBN cord-010119-t1x9gknd 7268 7 in in IN cord-010119-t1x9gknd 7268 8 the the DT cord-010119-t1x9gknd 7268 9 reactivity reactivity NN cord-010119-t1x9gknd 7268 10 of of IN cord-010119-t1x9gknd 7268 11 D d NN cord-010119-t1x9gknd 7268 12 among among IN cord-010119-t1x9gknd 7268 13 the the DT cord-010119-t1x9gknd 7268 14 samples sample NNS cord-010119-t1x9gknd 7268 15 carrying carry VBG cord-010119-t1x9gknd 7268 16 the the DT cord-010119-t1x9gknd 7268 17 ( ( -LRB- cord-010119-t1x9gknd 7268 18 C)ce C)ce NNP cord-010119-t1x9gknd 7268 19 s s POS cord-010119-t1x9gknd 7268 20 allele allele NN cord-010119-t1x9gknd 7268 21 and and CC cord-010119-t1x9gknd 7268 22 in in IN cord-010119-t1x9gknd 7268 23 the the DT cord-010119-t1x9gknd 7268 24 samples sample NNS cord-010119-t1x9gknd 7268 25 homozygous homozygous JJ cord-010119-t1x9gknd 7268 26 for for IN cord-010119-t1x9gknd 7268 27 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 7268 28 . . . cord-010119-t1x9gknd 7269 1 The the DT cord-010119-t1x9gknd 7269 2 results result NNS cord-010119-t1x9gknd 7269 3 showed show VBD cord-010119-t1x9gknd 7269 4 that that IN cord-010119-t1x9gknd 7269 5 the the DT cord-010119-t1x9gknd 7269 6 presence presence NN cord-010119-t1x9gknd 7269 7 of of IN cord-010119-t1x9gknd 7269 8 RHCE*(C)ce RHCE*(C)ce NNP cord-010119-t1x9gknd 7269 9 S S NNP cord-010119-t1x9gknd 7269 10 significantly significantly RB cord-010119-t1x9gknd 7269 11 reduces reduce VBZ cord-010119-t1x9gknd 7269 12 the the DT cord-010119-t1x9gknd 7269 13 expression expression NN cord-010119-t1x9gknd 7269 14 of of IN cord-010119-t1x9gknd 7269 15 D D NNP cord-010119-t1x9gknd 7269 16 antigen antigen NN cord-010119-t1x9gknd 7269 17 , , , cord-010119-t1x9gknd 7269 18 probably probably RB cord-010119-t1x9gknd 7269 19 due due IN cord-010119-t1x9gknd 7269 20 to to IN cord-010119-t1x9gknd 7269 21 the the DT cord-010119-t1x9gknd 7269 22 expression expression NN cord-010119-t1x9gknd 7269 23 of of IN cord-010119-t1x9gknd 7269 24 the the DT cord-010119-t1x9gknd 7269 25 partial partial JJ cord-010119-t1x9gknd 7269 26 C C NNP cord-010119-t1x9gknd 7269 27 partial partial JJ cord-010119-t1x9gknd 7269 28 antigen antigen NN cord-010119-t1x9gknd 7269 29 in in IN cord-010119-t1x9gknd 7269 30 trans trans NNP cord-010119-t1x9gknd 7269 31 to to IN cord-010119-t1x9gknd 7269 32 RhD. RhD. NNP cord-010119-t1x9gknd 7269 33 Additionally additionally RB cord-010119-t1x9gknd 7269 34 , , , cord-010119-t1x9gknd 7269 35 the the DT cord-010119-t1x9gknd 7269 36 samples sample NNS cord-010119-t1x9gknd 7269 37 with with IN cord-010119-t1x9gknd 7269 38 reduction reduction NN cord-010119-t1x9gknd 7269 39 on on IN cord-010119-t1x9gknd 7269 40 D d NN cord-010119-t1x9gknd 7269 41 expression expression NN cord-010119-t1x9gknd 7269 42 carrying carry VBG cord-010119-t1x9gknd 7269 43 RHCE RHCE NNP cord-010119-t1x9gknd 7269 44 variant variant NN cord-010119-t1x9gknd 7269 45 alelles alelle NNS cord-010119-t1x9gknd 7269 46 phenotype phenotype NN cord-010119-t1x9gknd 7269 47 can can MD cord-010119-t1x9gknd 7269 48 be be VB cord-010119-t1x9gknd 7269 49 useful useful JJ cord-010119-t1x9gknd 7269 50 to to TO cord-010119-t1x9gknd 7269 51 provide provide VB cord-010119-t1x9gknd 7269 52 compatible compatible JJ cord-010119-t1x9gknd 7269 53 blood blood NN cord-010119-t1x9gknd 7269 54 to to IN cord-010119-t1x9gknd 7269 55 some some DT cord-010119-t1x9gknd 7269 56 patients patient NNS cord-010119-t1x9gknd 7269 57 with with IN cord-010119-t1x9gknd 7269 58 rareRH rareRH NNP cord-010119-t1x9gknd 7269 59 variant variant NN cord-010119-t1x9gknd 7269 60 alleles allele NNS cord-010119-t1x9gknd 7269 61 . . . cord-010119-t1x9gknd 7270 1 Background Background NNP cord-010119-t1x9gknd 7270 2 / / SYM cord-010119-t1x9gknd 7270 3 Case Case NNP cord-010119-t1x9gknd 7270 4 Studies Studies NNPS cord-010119-t1x9gknd 7270 5 : : : cord-010119-t1x9gknd 7271 1 Drugs drug NNS cord-010119-t1x9gknd 7271 2 are be VBP cord-010119-t1x9gknd 7271 3 known know VBN cord-010119-t1x9gknd 7271 4 to to TO cord-010119-t1x9gknd 7271 5 interfere interfere VB cord-010119-t1x9gknd 7271 6 with with IN cord-010119-t1x9gknd 7271 7 routine routine JJ cord-010119-t1x9gknd 7271 8 blood blood NN cord-010119-t1x9gknd 7271 9 bank bank NN cord-010119-t1x9gknd 7271 10 testing testing NN cord-010119-t1x9gknd 7271 11 . . . cord-010119-t1x9gknd 7272 1 A a DT cord-010119-t1x9gknd 7272 2 novel novel JJ cord-010119-t1x9gknd 7272 3 monoclonal monoclonal NN cord-010119-t1x9gknd 7272 4 humanized humanize VBN cord-010119-t1x9gknd 7272 5 5F9 5f9 CD cord-010119-t1x9gknd 7272 6 antibody antibody NN cord-010119-t1x9gknd 7272 7 ( ( -LRB- cord-010119-t1x9gknd 7272 8 Hu5F9-G4 Hu5F9-G4 MD cord-010119-t1x9gknd 7272 9 ) ) -RRB- cord-010119-t1x9gknd 7272 10 that that WDT cord-010119-t1x9gknd 7272 11 binds bind VBZ cord-010119-t1x9gknd 7272 12 human human JJ cord-010119-t1x9gknd 7272 13 CD47 CD47 NNP cord-010119-t1x9gknd 7272 14 has have VBZ cord-010119-t1x9gknd 7272 15 been be VBN cord-010119-t1x9gknd 7272 16 entered enter VBN cord-010119-t1x9gknd 7272 17 into into IN cord-010119-t1x9gknd 7272 18 clinical clinical JJ cord-010119-t1x9gknd 7272 19 trials trial NNS cord-010119-t1x9gknd 7272 20 for for IN cord-010119-t1x9gknd 7272 21 patients patient NNS cord-010119-t1x9gknd 7272 22 with with IN cord-010119-t1x9gknd 7272 23 acute acute JJ cord-010119-t1x9gknd 7272 24 myeloid myeloid NN cord-010119-t1x9gknd 7272 25 leukemia leukemia NN cord-010119-t1x9gknd 7272 26 , , , cord-010119-t1x9gknd 7272 27 non non JJ cord-010119-t1x9gknd 7272 28 - - JJ cord-010119-t1x9gknd 7272 29 Hodgkin Hodgkin NNP cord-010119-t1x9gknd 7272 30 lymphoma lymphoma NN cord-010119-t1x9gknd 7272 31 and and CC cord-010119-t1x9gknd 7272 32 solid solid JJ cord-010119-t1x9gknd 7272 33 tumors tumor NNS cord-010119-t1x9gknd 7272 34 . . . cord-010119-t1x9gknd 7273 1 We -PRON- PRP cord-010119-t1x9gknd 7273 2 describe describe VBP cord-010119-t1x9gknd 7273 3 two two CD cord-010119-t1x9gknd 7273 4 cases case NNS cord-010119-t1x9gknd 7273 5 of of IN cord-010119-t1x9gknd 7273 6 patients patient NNS cord-010119-t1x9gknd 7273 7 treated treat VBN cord-010119-t1x9gknd 7273 8 with with IN cord-010119-t1x9gknd 7273 9 Hu5F9-G4 Hu5F9-G4 NNP cord-010119-t1x9gknd 7273 10 ( ( -LRB- cord-010119-t1x9gknd 7273 11 anti anti JJ cord-010119-t1x9gknd 7273 12 - - JJ cord-010119-t1x9gknd 7273 13 CD47 cd47 JJ cord-010119-t1x9gknd 7273 14 ) ) -RRB- cord-010119-t1x9gknd 7273 15 who who WP cord-010119-t1x9gknd 7273 16 had have VBD cord-010119-t1x9gknd 7273 17 ABO ABO NNP cord-010119-t1x9gknd 7273 18 discrepancy discrepancy NN cord-010119-t1x9gknd 7273 19 with with IN cord-010119-t1x9gknd 7273 20 extra extra JJ cord-010119-t1x9gknd 7273 21 - - HYPH cord-010119-t1x9gknd 7273 22 reactivity reactivity NN cord-010119-t1x9gknd 7273 23 in in IN cord-010119-t1x9gknd 7273 24 the the DT cord-010119-t1x9gknd 7273 25 reverse reverse NN cord-010119-t1x9gknd 7273 26 typing typing NN cord-010119-t1x9gknd 7273 27 and and CC cord-010119-t1x9gknd 7273 28 a a DT cord-010119-t1x9gknd 7273 29 panaggutinin panaggutinin NN cord-010119-t1x9gknd 7273 30 in in IN cord-010119-t1x9gknd 7273 31 the the DT cord-010119-t1x9gknd 7273 32 plasma plasma NN cord-010119-t1x9gknd 7273 33 . . . cord-010119-t1x9gknd 7274 1 Study Study NNP cord-010119-t1x9gknd 7274 2 Design Design NNP cord-010119-t1x9gknd 7274 3 / / SYM cord-010119-t1x9gknd 7274 4 Method method NN cord-010119-t1x9gknd 7274 5 : : : cord-010119-t1x9gknd 7274 6 This this DT cord-010119-t1x9gknd 7274 7 is be VBZ cord-010119-t1x9gknd 7274 8 a a DT cord-010119-t1x9gknd 7274 9 retrospective retrospective JJ cord-010119-t1x9gknd 7274 10 review review NN cord-010119-t1x9gknd 7274 11 of of IN cord-010119-t1x9gknd 7274 12 two two CD cord-010119-t1x9gknd 7274 13 cases case NNS cord-010119-t1x9gknd 7274 14 with with IN cord-010119-t1x9gknd 7274 15 immunohematology immunohematology NN cord-010119-t1x9gknd 7274 16 work work NN cord-010119-t1x9gknd 7274 17 - - HYPH cord-010119-t1x9gknd 7274 18 up up NN cord-010119-t1x9gknd 7274 19 showing show VBG cord-010119-t1x9gknd 7274 20 ABO ABO NNP cord-010119-t1x9gknd 7274 21 discrepancy discrepancy NN cord-010119-t1x9gknd 7274 22 and and CC cord-010119-t1x9gknd 7274 23 plasma plasma NN cord-010119-t1x9gknd 7274 24 panagglutinin panagglutinin NNS cord-010119-t1x9gknd 7274 25 . . . cord-010119-t1x9gknd 7275 1 The the DT cord-010119-t1x9gknd 7275 2 first first JJ cord-010119-t1x9gknd 7275 3 case case NN cord-010119-t1x9gknd 7275 4 is be VBZ cord-010119-t1x9gknd 7275 5 of of IN cord-010119-t1x9gknd 7275 6 a a DT cord-010119-t1x9gknd 7275 7 69 69 CD cord-010119-t1x9gknd 7275 8 year year NN cord-010119-t1x9gknd 7275 9 old old JJ cord-010119-t1x9gknd 7275 10 female female NN cord-010119-t1x9gknd 7275 11 with with IN cord-010119-t1x9gknd 7275 12 progressive progressive JJ cord-010119-t1x9gknd 7275 13 follicular follicular JJ cord-010119-t1x9gknd 7275 14 lymphoma lymphoma NN cord-010119-t1x9gknd 7275 15 who who WP cord-010119-t1x9gknd 7275 16 was be VBD cord-010119-t1x9gknd 7275 17 enrolled enrol VBN cord-010119-t1x9gknd 7275 18 in in IN cord-010119-t1x9gknd 7275 19 Phase Phase NNP cord-010119-t1x9gknd 7275 20 1b/2 1b/2 CD cord-010119-t1x9gknd 7275 21 Trial Trial NNP cord-010119-t1x9gknd 7275 22 of of IN cord-010119-t1x9gknd 7275 23 Hu5F9 Hu5F9 NNP cord-010119-t1x9gknd 7275 24 G4 G4 NNP cord-010119-t1x9gknd 7275 25 in in IN cord-010119-t1x9gknd 7275 26 combination combination NN cord-010119-t1x9gknd 7275 27 with with IN cord-010119-t1x9gknd 7275 28 rituximab rituximab NN cord-010119-t1x9gknd 7275 29 designed design VBN cord-010119-t1x9gknd 7275 30 for for IN cord-010119-t1x9gknd 7275 31 patients patient NNS cord-010119-t1x9gknd 7275 32 with with IN cord-010119-t1x9gknd 7275 33 relapsed relapse VBN cord-010119-t1x9gknd 7275 34 / / SYM cord-010119-t1x9gknd 7275 35 refractory refractory JJ cord-010119-t1x9gknd 7275 36 B B NNP cord-010119-t1x9gknd 7275 37 cell cell NN cord-010119-t1x9gknd 7275 38 NHL NHL NNP cord-010119-t1x9gknd 7275 39 . . . cord-010119-t1x9gknd 7276 1 She -PRON- PRP cord-010119-t1x9gknd 7276 2 had have VBD cord-010119-t1x9gknd 7276 3 no no DT cord-010119-t1x9gknd 7276 4 prior prior JJ cord-010119-t1x9gknd 7276 5 transfusion transfusion NN cord-010119-t1x9gknd 7276 6 history history NN cord-010119-t1x9gknd 7276 7 and and CC cord-010119-t1x9gknd 7276 8 her -PRON- PRP$ cord-010119-t1x9gknd 7276 9 historical historical JJ cord-010119-t1x9gknd 7276 10 blood blood NN cord-010119-t1x9gknd 7276 11 type type NN cord-010119-t1x9gknd 7276 12 was be VBD cord-010119-t1x9gknd 7276 13 not not RB cord-010119-t1x9gknd 7276 14 known know VBN cord-010119-t1x9gknd 7276 15 . . . cord-010119-t1x9gknd 7277 1 Two two CD cord-010119-t1x9gknd 7277 2 RBC RBC NNP cord-010119-t1x9gknd 7277 3 units unit NNS cord-010119-t1x9gknd 7277 4 were be VBD cord-010119-t1x9gknd 7277 5 requested request VBN cord-010119-t1x9gknd 7277 6 in in IN cord-010119-t1x9gknd 7277 7 anticipation anticipation NN cord-010119-t1x9gknd 7277 8 for for IN cord-010119-t1x9gknd 7277 9 a a DT cord-010119-t1x9gknd 7277 10 surgical surgical JJ cord-010119-t1x9gknd 7277 11 procedure procedure NN cord-010119-t1x9gknd 7277 12 . . . cord-010119-t1x9gknd 7278 1 The the DT cord-010119-t1x9gknd 7278 2 second second JJ cord-010119-t1x9gknd 7278 3 case case NN cord-010119-t1x9gknd 7278 4 is be VBZ cord-010119-t1x9gknd 7278 5 of of IN cord-010119-t1x9gknd 7278 6 a a DT cord-010119-t1x9gknd 7278 7 48 48 CD cord-010119-t1x9gknd 7278 8 year year NN cord-010119-t1x9gknd 7278 9 old old JJ cord-010119-t1x9gknd 7278 10 male male NN cord-010119-t1x9gknd 7278 11 with with IN cord-010119-t1x9gknd 7278 12 refractory refractory JJ cord-010119-t1x9gknd 7278 13 diffuse diffuse VB cord-010119-t1x9gknd 7278 14 large large JJ cord-010119-t1x9gknd 7278 15 B b NN cord-010119-t1x9gknd 7278 16 cell cell NN cord-010119-t1x9gknd 7278 17 lymphoma lymphoma NN cord-010119-t1x9gknd 7278 18 enrolled enrol VBN cord-010119-t1x9gknd 7278 19 in in IN cord-010119-t1x9gknd 7278 20 Hu5F9-G4 Hu5F9-G4 NNP cord-010119-t1x9gknd 7278 21 clinical clinical JJ cord-010119-t1x9gknd 7278 22 trial trial NN cord-010119-t1x9gknd 7278 23 . . . cord-010119-t1x9gknd 7279 1 His -PRON- PRP$ cord-010119-t1x9gknd 7279 2 historical historical JJ cord-010119-t1x9gknd 7279 3 blood blood NN cord-010119-t1x9gknd 7279 4 type type NN cord-010119-t1x9gknd 7279 5 was be VBD cord-010119-t1x9gknd 7279 6 A a DT cord-010119-t1x9gknd 7279 7 Rh Rh NNP cord-010119-t1x9gknd 7279 8 D d NN cord-010119-t1x9gknd 7279 9 positive positive JJ cord-010119-t1x9gknd 7279 10 with with IN cord-010119-t1x9gknd 7279 11 a a DT cord-010119-t1x9gknd 7279 12 negative negative JJ cord-010119-t1x9gknd 7279 13 antibody antibody NN cord-010119-t1x9gknd 7279 14 screen screen NN cord-010119-t1x9gknd 7279 15 . . . cord-010119-t1x9gknd 7280 1 He -PRON- PRP cord-010119-t1x9gknd 7280 2 received receive VBD cord-010119-t1x9gknd 7280 3 three three CD cord-010119-t1x9gknd 7280 4 RBC RBC NNP cord-010119-t1x9gknd 7280 5 units unit NNS cord-010119-t1x9gknd 7280 6 within within IN cord-010119-t1x9gknd 7280 7 the the DT cord-010119-t1x9gknd 7280 8 past past JJ cord-010119-t1x9gknd 7280 9 month month NN cord-010119-t1x9gknd 7280 10 prior prior RB cord-010119-t1x9gknd 7280 11 to to IN cord-010119-t1x9gknd 7280 12 testing test VBG cord-010119-t1x9gknd 7280 13 and and CC cord-010119-t1x9gknd 7280 14 receiving receive VBG cord-010119-t1x9gknd 7280 15 the the DT cord-010119-t1x9gknd 7280 16 anti anti JJ cord-010119-t1x9gknd 7280 17 - - JJ cord-010119-t1x9gknd 7280 18 CD47 cd47 JJ cord-010119-t1x9gknd 7280 19 therapy therapy NN cord-010119-t1x9gknd 7280 20 . . . cord-010119-t1x9gknd 7281 1 Results/ Results/ . cord-010119-t1x9gknd 7282 1 Finding finding NN cord-010119-t1x9gknd 7282 2 : : : cord-010119-t1x9gknd 7283 1 The the DT cord-010119-t1x9gknd 7283 2 ABO ABO NNP cord-010119-t1x9gknd 7283 3 typing typing NN cord-010119-t1x9gknd 7283 4 in in IN cord-010119-t1x9gknd 7283 5 the the DT cord-010119-t1x9gknd 7283 6 first first JJ cord-010119-t1x9gknd 7283 7 case case NN cord-010119-t1x9gknd 7283 8 showed show VBD cord-010119-t1x9gknd 7283 9 a a DT cord-010119-t1x9gknd 7283 10 discrepancy discrepancy NN cord-010119-t1x9gknd 7283 11 between between IN cord-010119-t1x9gknd 7283 12 the the DT cord-010119-t1x9gknd 7283 13 forward forward JJ cord-010119-t1x9gknd 7283 14 typing typing NN cord-010119-t1x9gknd 7283 15 ( ( -LRB- cord-010119-t1x9gknd 7283 16 41 41 CD cord-010119-t1x9gknd 7283 17 with with IN cord-010119-t1x9gknd 7283 18 anti anti JJ cord-010119-t1x9gknd 7283 19 - - JJ cord-010119-t1x9gknd 7283 20 A a JJ cord-010119-t1x9gknd 7283 21 , , , cord-010119-t1x9gknd 7283 22 non non JJ cord-010119-t1x9gknd 7283 23 - - JJ cord-010119-t1x9gknd 7283 24 reactive reactive JJ cord-010119-t1x9gknd 7283 25 with with IN cord-010119-t1x9gknd 7283 26 anti anti JJ cord-010119-t1x9gknd 7283 27 - - JJ cord-010119-t1x9gknd 7283 28 B b NN cord-010119-t1x9gknd 7283 29 ) ) -RRB- cord-010119-t1x9gknd 7283 30 and and CC cord-010119-t1x9gknd 7283 31 the the DT cord-010119-t1x9gknd 7283 32 reverse reverse JJ cord-010119-t1x9gknd 7283 33 typing typing NN cord-010119-t1x9gknd 7283 34 ( ( -LRB- cord-010119-t1x9gknd 7283 35 31 31 CD cord-010119-t1x9gknd 7283 36 with with IN cord-010119-t1x9gknd 7283 37 both both CC cord-010119-t1x9gknd 7283 38 A a DT cord-010119-t1x9gknd 7283 39 1 1 CD cord-010119-t1x9gknd 7283 40 cells cell NNS cord-010119-t1x9gknd 7283 41 and and CC cord-010119-t1x9gknd 7283 42 B b NN cord-010119-t1x9gknd 7283 43 cells cell NNS cord-010119-t1x9gknd 7283 44 ) ) -RRB- cord-010119-t1x9gknd 7283 45 . . . cord-010119-t1x9gknd 7284 1 RhD RhD NNP cord-010119-t1x9gknd 7284 2 typing typing NN cord-010119-t1x9gknd 7284 3 was be VBD cord-010119-t1x9gknd 7284 4 positive positive JJ cord-010119-t1x9gknd 7284 5 . . . cord-010119-t1x9gknd 7285 1 The the DT cord-010119-t1x9gknd 7285 2 extended extended JJ cord-010119-t1x9gknd 7285 3 reagent reagent NN cord-010119-t1x9gknd 7285 4 RBC RBC NNP cord-010119-t1x9gknd 7285 5 panel panel NN cord-010119-t1x9gknd 7285 6 tested test VBN cord-010119-t1x9gknd 7285 7 with with IN cord-010119-t1x9gknd 7285 8 the the DT cord-010119-t1x9gknd 7285 9 patient patient NN cord-010119-t1x9gknd 7285 10 's 's POS cord-010119-t1x9gknd 7285 11 serum serum NN cord-010119-t1x9gknd 7285 12 reacted react VBD cord-010119-t1x9gknd 7285 13 with with IN cord-010119-t1x9gknd 7285 14 all all DT cord-010119-t1x9gknd 7285 15 cells cell NNS cord-010119-t1x9gknd 7285 16 tested test VBN cord-010119-t1x9gknd 7285 17 at at IN cord-010119-t1x9gknd 7285 18 the the DT cord-010119-t1x9gknd 7285 19 immediate immediate JJ cord-010119-t1x9gknd 7285 20 spin spin NN cord-010119-t1x9gknd 7285 21 ( ( -LRB- cord-010119-t1x9gknd 7285 22 IS is NN cord-010119-t1x9gknd 7285 23 ) ) -RRB- cord-010119-t1x9gknd 7285 24 phase phase NN cord-010119-t1x9gknd 7285 25 ( ( -LRB- cord-010119-t1x9gknd 7285 26 11 11 CD cord-010119-t1x9gknd 7285 27 to to IN cord-010119-t1x9gknd 7285 28 41 41 CD cord-010119-t1x9gknd 7285 29 ) ) -RRB- cord-010119-t1x9gknd 7285 30 , , , cord-010119-t1x9gknd 7285 31 at at IN cord-010119-t1x9gknd 7285 32 LISS-37C LISS-37C NNP cord-010119-t1x9gknd 7285 33 ( ( -LRB- cord-010119-t1x9gknd 7285 34 11 11 CD cord-010119-t1x9gknd 7285 35 to to IN cord-010119-t1x9gknd 7285 36 31 31 CD cord-010119-t1x9gknd 7285 37 ) ) -RRB- cord-010119-t1x9gknd 7285 38 , , , cord-010119-t1x9gknd 7285 39 at at IN cord-010119-t1x9gknd 7285 40 LISS LISS NNP cord-010119-t1x9gknd 7285 41 - - HYPH cord-010119-t1x9gknd 7285 42 polyspecific polyspecific NNP cord-010119-t1x9gknd 7285 43 AHG AHG NNP cord-010119-t1x9gknd 7285 44 ( ( -LRB- cord-010119-t1x9gknd 7285 45 m1 m1 NNP cord-010119-t1x9gknd 7285 46 ) ) -RRB- cord-010119-t1x9gknd 7285 47 , , , cord-010119-t1x9gknd 7285 48 and and CC cord-010119-t1x9gknd 7285 49 at at IN cord-010119-t1x9gknd 7285 50 PEG peg NN cord-010119-t1x9gknd 7285 51 - - HYPH cord-010119-t1x9gknd 7285 52 anti anti JJ cord-010119-t1x9gknd 7285 53 - - JJ cord-010119-t1x9gknd 7285 54 IgG igg JJ cord-010119-t1x9gknd 7285 55 ( ( -LRB- cord-010119-t1x9gknd 7285 56 m1 m1 NNP cord-010119-t1x9gknd 7285 57 to to IN cord-010119-t1x9gknd 7285 58 11 11 CD cord-010119-t1x9gknd 7285 59 ) ) -RRB- cord-010119-t1x9gknd 7285 60 . . . cord-010119-t1x9gknd 7286 1 Plasma plasma NN cord-010119-t1x9gknd 7286 2 reactivity reactivity NN cord-010119-t1x9gknd 7286 3 at at IN cord-010119-t1x9gknd 7286 4 IS be VBZ cord-010119-t1x9gknd 7286 5 persisted persist VBN cord-010119-t1x9gknd 7286 6 with with IN cord-010119-t1x9gknd 7286 7 DTT DTT NNP cord-010119-t1x9gknd 7286 8 or or CC cord-010119-t1x9gknd 7286 9 ficin ficin NNS cord-010119-t1x9gknd 7286 10 treated treat VBN cord-010119-t1x9gknd 7286 11 red red JJ cord-010119-t1x9gknd 7286 12 cells cell NNS cord-010119-t1x9gknd 7286 13 and and CC cord-010119-t1x9gknd 7286 14 was be VBD cord-010119-t1x9gknd 7286 15 not not RB cord-010119-t1x9gknd 7286 16 removed remove VBN cord-010119-t1x9gknd 7286 17 by by IN cord-010119-t1x9gknd 7286 18 cold cold JJ cord-010119-t1x9gknd 7286 19 autoadsorption autoadsorption NN cord-010119-t1x9gknd 7286 20 , , , cord-010119-t1x9gknd 7286 21 cold cold JJ cord-010119-t1x9gknd 7286 22 alloadsorption alloadsorption NN cord-010119-t1x9gknd 7286 23 , , , cord-010119-t1x9gknd 7286 24 or or CC cord-010119-t1x9gknd 7286 25 RESt RESt NNS cord-010119-t1x9gknd 7286 26 adsorption adsorption NN cord-010119-t1x9gknd 7286 27 . . . cord-010119-t1x9gknd 7287 1 Repeat repeat NN cord-010119-t1x9gknd 7287 2 testing testing NN cord-010119-t1x9gknd 7287 3 , , , cord-010119-t1x9gknd 7287 4 which which WDT cord-010119-t1x9gknd 7287 5 avoided avoid VBD cord-010119-t1x9gknd 7287 6 the the DT cord-010119-t1x9gknd 7287 7 IS is NN cord-010119-t1x9gknd 7287 8 and and CC cord-010119-t1x9gknd 7287 9 37C 37c CD cord-010119-t1x9gknd 7287 10 readings reading NNS cord-010119-t1x9gknd 7287 11 , , , cord-010119-t1x9gknd 7287 12 was be VBD cord-010119-t1x9gknd 7287 13 non non JJ cord-010119-t1x9gknd 7287 14 - - JJ cord-010119-t1x9gknd 7287 15 reactive reactive JJ cord-010119-t1x9gknd 7287 16 in in IN cord-010119-t1x9gknd 7287 17 the the DT cord-010119-t1x9gknd 7287 18 antihuman antihuman JJ cord-010119-t1x9gknd 7287 19 globulin globulin NN cord-010119-t1x9gknd 7287 20 ( ( -LRB- cord-010119-t1x9gknd 7287 21 AHG AHG NNP cord-010119-t1x9gknd 7287 22 ) ) -RRB- cord-010119-t1x9gknd 7287 23 phase phase NN cord-010119-t1x9gknd 7287 24 using use VBG cord-010119-t1x9gknd 7287 25 both both CC cord-010119-t1x9gknd 7287 26 LISS LISS NNP cord-010119-t1x9gknd 7287 27 and and CC cord-010119-t1x9gknd 7287 28 PEG PEG NNP cord-010119-t1x9gknd 7287 29 enhancements enhancement NNS cord-010119-t1x9gknd 7287 30 , , , cord-010119-t1x9gknd 7287 31 ruling rule VBG cord-010119-t1x9gknd 7287 32 out out RP cord-010119-t1x9gknd 7287 33 clinically clinically RB cord-010119-t1x9gknd 7287 34 significant significant JJ cord-010119-t1x9gknd 7287 35 alloantibodies alloantibody NNS cord-010119-t1x9gknd 7287 36 directed direct VBN cord-010119-t1x9gknd 7287 37 toward toward IN cord-010119-t1x9gknd 7287 38 common common JJ cord-010119-t1x9gknd 7287 39 red red JJ cord-010119-t1x9gknd 7287 40 blood blood NN cord-010119-t1x9gknd 7287 41 cell cell NN cord-010119-t1x9gknd 7287 42 antigens antigen NNS cord-010119-t1x9gknd 7287 43 . . . cord-010119-t1x9gknd 7288 1 The the DT cord-010119-t1x9gknd 7288 2 Direct Direct NNP cord-010119-t1x9gknd 7288 3 Antiglobulin Antiglobulin NNP cord-010119-t1x9gknd 7288 4 Test test NN cord-010119-t1x9gknd 7288 5 ( ( -LRB- cord-010119-t1x9gknd 7288 6 DAT DAT NNP cord-010119-t1x9gknd 7288 7 ) ) -RRB- cord-010119-t1x9gknd 7288 8 and and CC cord-010119-t1x9gknd 7288 9 autocontrol autocontrol NNP cord-010119-t1x9gknd 7288 10 were be VBD cord-010119-t1x9gknd 7288 11 negative negative JJ cord-010119-t1x9gknd 7288 12 . . . cord-010119-t1x9gknd 7289 1 The the DT cord-010119-t1x9gknd 7289 2 RBC RBC NNP cord-010119-t1x9gknd 7289 3 units unit NNS cord-010119-t1x9gknd 7289 4 issued issue VBN cord-010119-t1x9gknd 7289 5 to to IN cord-010119-t1x9gknd 7289 6 the the DT cord-010119-t1x9gknd 7289 7 patient patient NN cord-010119-t1x9gknd 7289 8 were be VBD cord-010119-t1x9gknd 7289 9 crossmatch crossmatch VBN cord-010119-t1x9gknd 7289 10 compatible compatible JJ cord-010119-t1x9gknd 7289 11 at at IN cord-010119-t1x9gknd 7289 12 37 37 CD cord-010119-t1x9gknd 7289 13 o o NN cord-010119-t1x9gknd 7289 14 C c NN cord-010119-t1x9gknd 7289 15 AHG AHG NNP cord-010119-t1x9gknd 7289 16 phase phase NN cord-010119-t1x9gknd 7289 17 . . . cord-010119-t1x9gknd 7290 1 The the DT cord-010119-t1x9gknd 7290 2 ABO ABO NNP cord-010119-t1x9gknd 7290 3 typing typing NN cord-010119-t1x9gknd 7290 4 of of IN cord-010119-t1x9gknd 7290 5 the the DT cord-010119-t1x9gknd 7290 6 second second JJ cord-010119-t1x9gknd 7290 7 case case NN cord-010119-t1x9gknd 7290 8 performed perform VBN cord-010119-t1x9gknd 7290 9 after after IN cord-010119-t1x9gknd 7290 10 anti anti JJ cord-010119-t1x9gknd 7290 11 - - JJ cord-010119-t1x9gknd 7290 12 CD47 cd47 JJ cord-010119-t1x9gknd 7290 13 administration administration NN cord-010119-t1x9gknd 7290 14 showed show VBD cord-010119-t1x9gknd 7290 15 a a DT cord-010119-t1x9gknd 7290 16 discrepancy discrepancy NN cord-010119-t1x9gknd 7290 17 between between IN cord-010119-t1x9gknd 7290 18 the the DT cord-010119-t1x9gknd 7290 19 forward forward NN cord-010119-t1x9gknd 7290 20 ( ( -LRB- cord-010119-t1x9gknd 7290 21 41 41 CD cord-010119-t1x9gknd 7290 22 with with IN cord-010119-t1x9gknd 7290 23 Anti Anti NNP cord-010119-t1x9gknd 7290 24 - - NNP cord-010119-t1x9gknd 7290 25 A A NNP cord-010119-t1x9gknd 7290 26 ) ) -RRB- cord-010119-t1x9gknd 7290 27 and and CC cord-010119-t1x9gknd 7290 28 the the DT cord-010119-t1x9gknd 7290 29 reverse reverse NN cord-010119-t1x9gknd 7290 30 ( ( -LRB- cord-010119-t1x9gknd 7290 31 41 41 CD cord-010119-t1x9gknd 7290 32 with with IN cord-010119-t1x9gknd 7290 33 both both CC cord-010119-t1x9gknd 7290 34 A A NNP cord-010119-t1x9gknd 7290 35 1 1 CD cord-010119-t1x9gknd 7290 36 and and CC cord-010119-t1x9gknd 7290 37 B b NN cord-010119-t1x9gknd 7290 38 cells cell NNS cord-010119-t1x9gknd 7290 39 ) ) -RRB- cord-010119-t1x9gknd 7290 40 . . . cord-010119-t1x9gknd 7291 1 RhD RhD NNP cord-010119-t1x9gknd 7291 2 typing typing NN cord-010119-t1x9gknd 7291 3 was be VBD cord-010119-t1x9gknd 7291 4 positive positive JJ cord-010119-t1x9gknd 7291 5 . . . cord-010119-t1x9gknd 7292 1 The the DT cord-010119-t1x9gknd 7292 2 antibody antibody NN cord-010119-t1x9gknd 7292 3 screen screen NN cord-010119-t1x9gknd 7292 4 performed perform VBN cord-010119-t1x9gknd 7292 5 in in IN cord-010119-t1x9gknd 7292 6 solid solid JJ cord-010119-t1x9gknd 7292 7 phase phase NN cord-010119-t1x9gknd 7292 8 technology technology NN cord-010119-t1x9gknd 7292 9 was be VBD cord-010119-t1x9gknd 7292 10 positive positive JJ cord-010119-t1x9gknd 7292 11 with with IN cord-010119-t1x9gknd 7292 12 all all DT cord-010119-t1x9gknd 7292 13 reagent reagent JJ cord-010119-t1x9gknd 7292 14 red red JJ cord-010119-t1x9gknd 7292 15 cells cell NNS cord-010119-t1x9gknd 7292 16 . . . cord-010119-t1x9gknd 7293 1 His -PRON- PRP$ cord-010119-t1x9gknd 7293 2 plasma plasma NN cord-010119-t1x9gknd 7293 3 reacted react VBD cord-010119-t1x9gknd 7293 4 with with IN cord-010119-t1x9gknd 7293 5 all all DT cord-010119-t1x9gknd 7293 6 reagent reagent JJ cord-010119-t1x9gknd 7293 7 red red JJ cord-010119-t1x9gknd 7293 8 cells cell NNS cord-010119-t1x9gknd 7293 9 at at IN cord-010119-t1x9gknd 7293 10 IS IS NNP cord-010119-t1x9gknd 7293 11 ( ( -LRB- cord-010119-t1x9gknd 7293 12 21 21 CD cord-010119-t1x9gknd 7293 13 ) ) -RRB- cord-010119-t1x9gknd 7293 14 , , , cord-010119-t1x9gknd 7293 15 at at IN cord-010119-t1x9gknd 7293 16 37C 37c CD cord-010119-t1x9gknd 7293 17 in in IN cord-010119-t1x9gknd 7293 18 LISS LISS NNP cord-010119-t1x9gknd 7293 19 ( ( -LRB- cord-010119-t1x9gknd 7293 20 21 21 CD cord-010119-t1x9gknd 7293 21 ) ) -RRB- cord-010119-t1x9gknd 7293 22 , , , cord-010119-t1x9gknd 7293 23 and and CC cord-010119-t1x9gknd 7293 24 LISS LISS NNP cord-010119-t1x9gknd 7293 25 - - HYPH cord-010119-t1x9gknd 7293 26 polyspecific polyspecific NNP cord-010119-t1x9gknd 7293 27 AHG AHG NNP cord-010119-t1x9gknd 7293 28 ( ( -LRB- cord-010119-t1x9gknd 7293 29 m1 m1 NNP cord-010119-t1x9gknd 7293 30 ) ) -RRB- cord-010119-t1x9gknd 7293 31 . . . cord-010119-t1x9gknd 7294 1 The the DT cord-010119-t1x9gknd 7294 2 DAT DAT NNP cord-010119-t1x9gknd 7294 3 and and CC cord-010119-t1x9gknd 7294 4 autocontrol autocontrol NNP cord-010119-t1x9gknd 7294 5 were be VBD cord-010119-t1x9gknd 7294 6 negative negative JJ cord-010119-t1x9gknd 7294 7 . . . cord-010119-t1x9gknd 7295 1 His -PRON- PRP$ cord-010119-t1x9gknd 7295 2 genotype genotype NN cord-010119-t1x9gknd 7295 3 was be VBD cord-010119-t1x9gknd 7295 4 determined determine VBN cord-010119-t1x9gknd 7295 5 to to TO cord-010119-t1x9gknd 7295 6 be be VB cord-010119-t1x9gknd 7295 7 A1 A1 NNP cord-010119-t1x9gknd 7295 8 / / SYM cord-010119-t1x9gknd 7295 9 O o NN cord-010119-t1x9gknd 7295 10 and and CC cord-010119-t1x9gknd 7295 11 full full JJ cord-010119-t1x9gknd 7295 12 RBC RBC NNP cord-010119-t1x9gknd 7295 13 phenotype phenotype NN cord-010119-t1x9gknd 7295 14 by by IN cord-010119-t1x9gknd 7295 15 DNA dna NN cord-010119-t1x9gknd 7295 16 analysis analysis NN cord-010119-t1x9gknd 7295 17 was be VBD cord-010119-t1x9gknd 7295 18 obtained obtain VBN cord-010119-t1x9gknd 7295 19 . . . cord-010119-t1x9gknd 7296 1 Repeat repeat NN cord-010119-t1x9gknd 7296 2 testing testing NN cord-010119-t1x9gknd 7296 3 which which WDT cord-010119-t1x9gknd 7296 4 avoided avoid VBD cord-010119-t1x9gknd 7296 5 the the DT cord-010119-t1x9gknd 7296 6 IS IS NNP cord-010119-t1x9gknd 7296 7 phase phase NN cord-010119-t1x9gknd 7296 8 did do VBD cord-010119-t1x9gknd 7296 9 not not RB cord-010119-t1x9gknd 7296 10 show show VB cord-010119-t1x9gknd 7296 11 reactivity reactivity NN cord-010119-t1x9gknd 7296 12 at at IN cord-010119-t1x9gknd 7296 13 PEG PEG NNP cord-010119-t1x9gknd 7296 14 - - HYPH cord-010119-t1x9gknd 7296 15 AHG AHG NNP cord-010119-t1x9gknd 7296 16 excluding exclude VBG cord-010119-t1x9gknd 7296 17 all all DT cord-010119-t1x9gknd 7296 18 alloantibodies alloantibody NNS cord-010119-t1x9gknd 7296 19 directed direct VBN cord-010119-t1x9gknd 7296 20 toward toward IN cord-010119-t1x9gknd 7296 21 common common JJ cord-010119-t1x9gknd 7296 22 red red JJ cord-010119-t1x9gknd 7296 23 blood blood NN cord-010119-t1x9gknd 7296 24 cell cell NN cord-010119-t1x9gknd 7296 25 antigens antigen NNS cord-010119-t1x9gknd 7296 26 . . . cord-010119-t1x9gknd 7297 1 Conclusion conclusion NN cord-010119-t1x9gknd 7297 2 : : : cord-010119-t1x9gknd 7298 1 Anti anti JJ cord-010119-t1x9gknd 7298 2 - - JJ cord-010119-t1x9gknd 7298 3 CD47 cd47 JJ cord-010119-t1x9gknd 7298 4 therapy therapy NN cord-010119-t1x9gknd 7298 5 interferes interfere VBZ cord-010119-t1x9gknd 7298 6 with with IN cord-010119-t1x9gknd 7298 7 Blood Blood NNP cord-010119-t1x9gknd 7298 8 Bank Bank NNP cord-010119-t1x9gknd 7298 9 testing testing NN cord-010119-t1x9gknd 7298 10 by by IN cord-010119-t1x9gknd 7298 11 causing cause VBG cord-010119-t1x9gknd 7298 12 ABO ABO NNP cord-010119-t1x9gknd 7298 13 discrepancies discrepancy NNS cord-010119-t1x9gknd 7298 14 and and CC cord-010119-t1x9gknd 7298 15 panagglutinin panagglutinin VBP cord-010119-t1x9gknd 7298 16 reactivity reactivity NN cord-010119-t1x9gknd 7298 17 in in IN cord-010119-t1x9gknd 7298 18 the the DT cord-010119-t1x9gknd 7298 19 plasma plasma NN cord-010119-t1x9gknd 7298 20 at at IN cord-010119-t1x9gknd 7298 21 IS is NN cord-010119-t1x9gknd 7298 22 , , , cord-010119-t1x9gknd 7298 23 37C 37c CD cord-010119-t1x9gknd 7298 24 LISS LISS NNP cord-010119-t1x9gknd 7298 25 , , , cord-010119-t1x9gknd 7298 26 but but CC cord-010119-t1x9gknd 7298 27 not not RB cord-010119-t1x9gknd 7298 28 at at IN cord-010119-t1x9gknd 7298 29 AHG AHG NNP cord-010119-t1x9gknd 7298 30 phase phase NN cord-010119-t1x9gknd 7298 31 using use VBG cord-010119-t1x9gknd 7298 32 Gamma gamma NN cord-010119-t1x9gknd 7298 33 - - HYPH cord-010119-t1x9gknd 7298 34 clone clone NN cord-010119-t1x9gknd 7298 35 Anti Anti NNP cord-010119-t1x9gknd 7298 36 - - NNP cord-010119-t1x9gknd 7298 37 IgG IgG NNP cord-010119-t1x9gknd 7298 38 , , , cord-010119-t1x9gknd 7298 39 unlike unlike IN cord-010119-t1x9gknd 7298 40 the the DT cord-010119-t1x9gknd 7298 41 anti anti JJ cord-010119-t1x9gknd 7298 42 - - JJ cord-010119-t1x9gknd 7298 43 CD38 cd38 JJ cord-010119-t1x9gknd 7298 44 interference interference NN cord-010119-t1x9gknd 7298 45 . . . cord-010119-t1x9gknd 7299 1 Knowledge knowledge NN cord-010119-t1x9gknd 7299 2 of of IN cord-010119-t1x9gknd 7299 3 patient patient NN cord-010119-t1x9gknd 7299 4 's 's POS cord-010119-t1x9gknd 7299 5 blood blood NN cord-010119-t1x9gknd 7299 6 type type NN cord-010119-t1x9gknd 7299 7 and and CC cord-010119-t1x9gknd 7299 8 phenotype phenotype NN cord-010119-t1x9gknd 7299 9 before before IN cord-010119-t1x9gknd 7299 10 starting start VBG cord-010119-t1x9gknd 7299 11 this this DT cord-010119-t1x9gknd 7299 12 therapy therapy NN cord-010119-t1x9gknd 7299 13 is be VBZ cord-010119-t1x9gknd 7299 14 critical critical JJ cord-010119-t1x9gknd 7299 15 for for IN cord-010119-t1x9gknd 7299 16 providing provide VBG cord-010119-t1x9gknd 7299 17 safe safe JJ cord-010119-t1x9gknd 7299 18 blood blood NN cord-010119-t1x9gknd 7299 19 . . . cord-010119-t1x9gknd 7300 1 Background Background NNP cord-010119-t1x9gknd 7300 2 / / SYM cord-010119-t1x9gknd 7300 3 Case Case NNP cord-010119-t1x9gknd 7300 4 Studies Studies NNPS cord-010119-t1x9gknd 7300 5 : : : cord-010119-t1x9gknd 7301 1 A a DT cord-010119-t1x9gknd 7301 2 middle middle NN cord-010119-t1x9gknd 7301 3 - - HYPH cord-010119-t1x9gknd 7301 4 aged aged JJ cord-010119-t1x9gknd 7301 5 male male NN cord-010119-t1x9gknd 7301 6 with with IN cord-010119-t1x9gknd 7301 7 discrepant discrepant JJ cord-010119-t1x9gknd 7301 8 ABO ABO NNP cord-010119-t1x9gknd 7301 9 typing typing NN cord-010119-t1x9gknd 7301 10 results result NNS cord-010119-t1x9gknd 7301 11 was be VBD cord-010119-t1x9gknd 7301 12 investigated investigate VBN cord-010119-t1x9gknd 7301 13 . . . cord-010119-t1x9gknd 7302 1 Initial initial JJ cord-010119-t1x9gknd 7302 2 forward forward JJ cord-010119-t1x9gknd 7302 3 typing typing NN cord-010119-t1x9gknd 7302 4 was be VBD cord-010119-t1x9gknd 7302 5 group group NN cord-010119-t1x9gknd 7303 1 O o UH cord-010119-t1x9gknd 7304 1 but but CC cord-010119-t1x9gknd 7304 2 no no DT cord-010119-t1x9gknd 7304 3 anti anti NN cord-010119-t1x9gknd 7304 4 - - NN cord-010119-t1x9gknd 7304 5 B B NNP cord-010119-t1x9gknd 7304 6 was be VBD cord-010119-t1x9gknd 7304 7 seen see VBN cord-010119-t1x9gknd 7304 8 in in IN cord-010119-t1x9gknd 7304 9 the the DT cord-010119-t1x9gknd 7304 10 reverse reverse JJ cord-010119-t1x9gknd 7304 11 typing typing NN cord-010119-t1x9gknd 7304 12 . . . cord-010119-t1x9gknd 7305 1 An an DT cord-010119-t1x9gknd 7305 2 unexpected unexpected JJ cord-010119-t1x9gknd 7305 3 31 31 CD cord-010119-t1x9gknd 7305 4 reaction reaction NN cord-010119-t1x9gknd 7305 5 was be VBD cord-010119-t1x9gknd 7305 6 noted note VBN cord-010119-t1x9gknd 7305 7 with with IN cord-010119-t1x9gknd 7305 8 an an DT cord-010119-t1x9gknd 7305 9 anti anti JJ cord-010119-t1x9gknd 7305 10 - - JJ cord-010119-t1x9gknd 7305 11 A a NN cord-010119-t1x9gknd 7305 12 , , , cord-010119-t1x9gknd 7305 13 B b NN cord-010119-t1x9gknd 7305 14 reagent reagent NN cord-010119-t1x9gknd 7305 15 . . . cord-010119-t1x9gknd 7306 1 Genotyping genotype VBG cord-010119-t1x9gknd 7306 2 surprisingly surprisingly RB cord-010119-t1x9gknd 7306 3 showed show VBD cord-010119-t1x9gknd 7306 4 ABO*O.01.01/ abo*o.01.01/ CD cord-010119-t1x9gknd 7306 5 O.01.01 O.01.01 NNP cord-010119-t1x9gknd 7306 6 , , , cord-010119-t1x9gknd 7306 7 consistent consistent JJ cord-010119-t1x9gknd 7306 8 with with IN cord-010119-t1x9gknd 7306 9 group group NN cord-010119-t1x9gknd 7306 10 O. O. NNP cord-010119-t1x9gknd 7307 1 After after IN cord-010119-t1x9gknd 7307 2 initial initial JJ cord-010119-t1x9gknd 7307 3 testing testing NN cord-010119-t1x9gknd 7307 4 at at IN cord-010119-t1x9gknd 7307 5 the the DT cord-010119-t1x9gknd 7307 6 referring refer VBG cord-010119-t1x9gknd 7307 7 center center NN cord-010119-t1x9gknd 7307 8 , , , cord-010119-t1x9gknd 7307 9 samples sample NNS cord-010119-t1x9gknd 7307 10 were be VBD cord-010119-t1x9gknd 7307 11 sent send VBN cord-010119-t1x9gknd 7307 12 for for IN cord-010119-t1x9gknd 7307 13 extended extended JJ cord-010119-t1x9gknd 7307 14 analysis analysis NN cord-010119-t1x9gknd 7307 15 . . . cord-010119-t1x9gknd 7308 1 Study Study NNP cord-010119-t1x9gknd 7308 2 Design Design NNP cord-010119-t1x9gknd 7308 3 / / SYM cord-010119-t1x9gknd 7308 4 Method method NN cord-010119-t1x9gknd 7308 5 : : : cord-010119-t1x9gknd 7309 1 Standard standard JJ cord-010119-t1x9gknd 7309 2 serological serological JJ cord-010119-t1x9gknd 7309 3 methods method NNS cord-010119-t1x9gknd 7309 4 and and CC cord-010119-t1x9gknd 7309 5 flow flow NN cord-010119-t1x9gknd 7309 6 cytometry cytometry NN cord-010119-t1x9gknd 7309 7 were be VBD cord-010119-t1x9gknd 7309 8 used use VBN cord-010119-t1x9gknd 7309 9 . . . cord-010119-t1x9gknd 7310 1 A a DT cord-010119-t1x9gknd 7310 2 panel panel NN cord-010119-t1x9gknd 7310 3 of of IN cord-010119-t1x9gknd 7310 4 ABO ABO NNP cord-010119-t1x9gknd 7310 5 reagents reagent NNS cord-010119-t1x9gknd 7310 6 ( ( -LRB- cord-010119-t1x9gknd 7310 7 n523 n523 NNP cord-010119-t1x9gknd 7310 8 ) ) -RRB- cord-010119-t1x9gknd 7310 9 and and CC cord-010119-t1x9gknd 7310 10 lectins lectin NNS cord-010119-t1x9gknd 7310 11 were be VBD cord-010119-t1x9gknd 7310 12 tested test VBN cord-010119-t1x9gknd 7310 13 with with IN cord-010119-t1x9gknd 7310 14 both both DT cord-010119-t1x9gknd 7310 15 native native JJ cord-010119-t1x9gknd 7310 16 and and CC cord-010119-t1x9gknd 7310 17 papain papain NN cord-010119-t1x9gknd 7310 18 - - HYPH cord-010119-t1x9gknd 7310 19 treated treat VBN cord-010119-t1x9gknd 7310 20 red red JJ cord-010119-t1x9gknd 7310 21 blood blood NN cord-010119-t1x9gknd 7310 22 cells cell NNS cord-010119-t1x9gknd 7310 23 ( ( -LRB- cord-010119-t1x9gknd 7310 24 RBCs rbc NNS cord-010119-t1x9gknd 7310 25 ) ) -RRB- cord-010119-t1x9gknd 7310 26 . . . cord-010119-t1x9gknd 7311 1 Lewis Lewis NNP cord-010119-t1x9gknd 7311 2 phenotyping phenotyping NN cord-010119-t1x9gknd 7311 3 was be VBD cord-010119-t1x9gknd 7311 4 performed perform VBN cord-010119-t1x9gknd 7311 5 , , , cord-010119-t1x9gknd 7311 6 as as IN cord-010119-t1x9gknd 7311 7 was be VBD cord-010119-t1x9gknd 7311 8 genetic genetic JJ cord-010119-t1x9gknd 7311 9 testing testing NN cord-010119-t1x9gknd 7311 10 for for IN cord-010119-t1x9gknd 7311 11 ABO ABO NNP cord-010119-t1x9gknd 7311 12 , , , cord-010119-t1x9gknd 7311 13 GBGT1 GBGT1 NNP cord-010119-t1x9gknd 7311 14 and and CC cord-010119-t1x9gknd 7311 15 A4GALT A4GALT NNP cord-010119-t1x9gknd 7311 16 . . . cord-010119-t1x9gknd 7312 1 Papain papain NN cord-010119-t1x9gknd 7312 2 - - HYPH cord-010119-t1x9gknd 7312 3 treated treat VBN cord-010119-t1x9gknd 7312 4 patient patient NN cord-010119-t1x9gknd 7312 5 RBCs rbc NNS cord-010119-t1x9gknd 7312 6 were be VBD cord-010119-t1x9gknd 7312 7 used use VBN cord-010119-t1x9gknd 7312 8 to to TO cord-010119-t1x9gknd 7312 9 screen screen VB cord-010119-t1x9gknd 7312 10 donor donor NN cord-010119-t1x9gknd 7312 11 plasmas plasma NNS cord-010119-t1x9gknd 7312 12 ( ( -LRB- cord-010119-t1x9gknd 7312 13 n578 n578 NNP cord-010119-t1x9gknd 7312 14 ) ) -RRB- cord-010119-t1x9gknd 7312 15 and and CC cord-010119-t1x9gknd 7312 16 two two CD cord-010119-t1x9gknd 7312 17 reactive reactive JJ cord-010119-t1x9gknd 7312 18 plasmas plasma NNS cord-010119-t1x9gknd 7312 19 were be VBD cord-010119-t1x9gknd 7312 20 DTT DTT NNP cord-010119-t1x9gknd 7312 21 - - HYPH cord-010119-t1x9gknd 7312 22 treated treat VBN cord-010119-t1x9gknd 7312 23 . . . cord-010119-t1x9gknd 7313 1 Results/ Results/ . cord-010119-t1x9gknd 7314 1 Finding finding NN cord-010119-t1x9gknd 7314 2 : : : cord-010119-t1x9gknd 7315 1 Positive positive JJ cord-010119-t1x9gknd 7315 2 reactions reaction NNS cord-010119-t1x9gknd 7315 3 were be VBD cord-010119-t1x9gknd 7315 4 obtained obtain VBN cord-010119-t1x9gknd 7315 5 with with IN cord-010119-t1x9gknd 7315 6 3 3 CD cord-010119-t1x9gknd 7315 7 polyclonal polyclonal JJ cord-010119-t1x9gknd 7315 8 anti anti NN cord-010119-t1x9gknd 7315 9 - - JJ cord-010119-t1x9gknd 7315 10 A a NN cord-010119-t1x9gknd 7315 11 , , , cord-010119-t1x9gknd 7315 12 B b NN cord-010119-t1x9gknd 7315 13 and and CC cord-010119-t1x9gknd 7315 14 a a DT cord-010119-t1x9gknd 7315 15 monoclonal monoclonal JJ cord-010119-t1x9gknd 7315 16 anti anti NN cord-010119-t1x9gknd 7315 17 - - NN cord-010119-t1x9gknd 7315 18 B b JJ cord-010119-t1x9gknd 7315 19 ( ( -LRB- cord-010119-t1x9gknd 7315 20 clone clone NN cord-010119-t1x9gknd 7315 21 G1/2 G1/2 NNP cord-010119-t1x9gknd 7315 22 ) ) -RRB- cord-010119-t1x9gknd 7315 23 when when WRB cord-010119-t1x9gknd 7315 24 tested test VBN cord-010119-t1x9gknd 7315 25 with with IN cord-010119-t1x9gknd 7315 26 the the DT cord-010119-t1x9gknd 7315 27 patient patient NN cord-010119-t1x9gknd 7315 28 's 's POS cord-010119-t1x9gknd 7315 29 papain papain NN cord-010119-t1x9gknd 7315 30 - - HYPH cord-010119-t1x9gknd 7315 31 treated treat VBN cord-010119-t1x9gknd 7315 32 RBCs rbc NNS cord-010119-t1x9gknd 7315 33 . . . cord-010119-t1x9gknd 7316 1 A a DT cord-010119-t1x9gknd 7316 2 panel panel NN cord-010119-t1x9gknd 7316 3 of of IN cord-010119-t1x9gknd 7316 4 lectins lectin NNS cord-010119-t1x9gknd 7316 5 gave give VBD cord-010119-t1x9gknd 7316 6 negative negative JJ cord-010119-t1x9gknd 7316 7 results result NNS cord-010119-t1x9gknd 7316 8 . . . cord-010119-t1x9gknd 7317 1 Genetic genetic JJ cord-010119-t1x9gknd 7317 2 testing testing NN cord-010119-t1x9gknd 7317 3 confirmed confirm VBD cord-010119-t1x9gknd 7317 4 the the DT cord-010119-t1x9gknd 7317 5 predicted predict VBN cord-010119-t1x9gknd 7317 6 group group NN cord-010119-t1x9gknd 7317 7 O o NN cord-010119-t1x9gknd 7317 8 and and CC cord-010119-t1x9gknd 7317 9 ruled rule VBD cord-010119-t1x9gknd 7317 10 out out RP cord-010119-t1x9gknd 7317 11 the the DT cord-010119-t1x9gknd 7317 12 presence presence NN cord-010119-t1x9gknd 7317 13 of of IN cord-010119-t1x9gknd 7317 14 FORS1 fors1 NN cord-010119-t1x9gknd 7317 15 or or CC cord-010119-t1x9gknd 7317 16 NOR NOR NNP cord-010119-t1x9gknd 7317 17 antigens antigen NNS cord-010119-t1x9gknd 7317 18 . . . cord-010119-t1x9gknd 7318 1 The the DT cord-010119-t1x9gknd 7318 2 patient patient NN cord-010119-t1x9gknd 7318 3 was be VBD cord-010119-t1x9gknd 7318 4 Le(a Le(a NNP cord-010119-t1x9gknd 7318 5 - - HYPH cord-010119-t1x9gknd 7318 6 b1 b1 NNP cord-010119-t1x9gknd 7318 7 ) ) -RRB- cord-010119-t1x9gknd 7318 8 and and CC cord-010119-t1x9gknd 7318 9 thus thus RB cord-010119-t1x9gknd 7318 10 a a DT cord-010119-t1x9gknd 7318 11 secretor secretor NN cord-010119-t1x9gknd 7318 12 . . . cord-010119-t1x9gknd 7319 1 A a DT cord-010119-t1x9gknd 7319 2 positive positive JJ cord-010119-t1x9gknd 7319 3 crossmatch crossmatch NN cord-010119-t1x9gknd 7319 4 was be VBD cord-010119-t1x9gknd 7319 5 seen see VBN cord-010119-t1x9gknd 7319 6 with with IN cord-010119-t1x9gknd 7319 7 47 47 CD cord-010119-t1x9gknd 7319 8 % % NN cord-010119-t1x9gknd 7319 9 of of IN cord-010119-t1x9gknd 7319 10 group group NN cord-010119-t1x9gknd 7319 11 O o NN cord-010119-t1x9gknd 7319 12 plasmas plasma NNS cord-010119-t1x9gknd 7319 13 , , , cord-010119-t1x9gknd 7319 14 while while IN cord-010119-t1x9gknd 7319 15 no no DT cord-010119-t1x9gknd 7319 16 reactivity reactivity NN cord-010119-t1x9gknd 7319 17 was be VBD cord-010119-t1x9gknd 7319 18 obtained obtain VBN cord-010119-t1x9gknd 7319 19 with with IN cord-010119-t1x9gknd 7319 20 A a NN cord-010119-t1x9gknd 7319 21 or or CC cord-010119-t1x9gknd 7319 22 B b NN cord-010119-t1x9gknd 7319 23 plasmas plasma NNS cord-010119-t1x9gknd 7319 24 . . . cord-010119-t1x9gknd 7320 1 DTT DTT NNP cord-010119-t1x9gknd 7320 2 treatment treatment NN cord-010119-t1x9gknd 7320 3 of of IN cord-010119-t1x9gknd 7320 4 crossmatchpositive crossmatchpositive NNP cord-010119-t1x9gknd 7320 5 plasmas plasma NNS cord-010119-t1x9gknd 7320 6 indicated indicate VBD cord-010119-t1x9gknd 7320 7 the the DT cord-010119-t1x9gknd 7320 8 antibody antibody NN cord-010119-t1x9gknd 7320 9 to to TO cord-010119-t1x9gknd 7320 10 be be VB cord-010119-t1x9gknd 7320 11 mainly mainly RB cord-010119-t1x9gknd 7320 12 of of IN cord-010119-t1x9gknd 7320 13 IgG IgG NNP cord-010119-t1x9gknd 7320 14 type type NN cord-010119-t1x9gknd 7320 15 . . . cord-010119-t1x9gknd 7321 1 This this DT cord-010119-t1x9gknd 7321 2 was be VBD cord-010119-t1x9gknd 7321 3 confirmed confirm VBN cord-010119-t1x9gknd 7321 4 by by IN cord-010119-t1x9gknd 7321 5 positive positive JJ cord-010119-t1x9gknd 7321 6 flow flow NN cord-010119-t1x9gknd 7321 7 cytometry cytometry NN cord-010119-t1x9gknd 7321 8 cross cross NN cord-010119-t1x9gknd 7321 9 match match NN cord-010119-t1x9gknd 7321 10 using use VBG cord-010119-t1x9gknd 7321 11 anti anti JJ cord-010119-t1x9gknd 7321 12 - - JJ cord-010119-t1x9gknd 7321 13 human human JJ cord-010119-t1x9gknd 7321 14 IgG IgG NNP cord-010119-t1x9gknd 7321 15 secondary secondary JJ cord-010119-t1x9gknd 7321 16 antibodies antibody NNS cord-010119-t1x9gknd 7321 17 . . . cord-010119-t1x9gknd 7322 1 Reactivity reactivity NN cord-010119-t1x9gknd 7322 2 remained remain VBD cord-010119-t1x9gknd 7322 3 after after IN cord-010119-t1x9gknd 7322 4 B B NNP cord-010119-t1x9gknd 7322 5 - - HYPH cord-010119-t1x9gknd 7322 6 zyme zyme NNP cord-010119-t1x9gknd 7322 7 treatment treatment NN cord-010119-t1x9gknd 7322 8 , , , cord-010119-t1x9gknd 7322 9 thus thus RB cord-010119-t1x9gknd 7322 10 excluding exclude VBG cord-010119-t1x9gknd 7322 11 the the DT cord-010119-t1x9gknd 7322 12 normal normal JJ cord-010119-t1x9gknd 7322 13 ( ( -LRB- cord-010119-t1x9gknd 7322 14 type type NN cord-010119-t1x9gknd 7322 15 1 1 CD cord-010119-t1x9gknd 7322 16 or or CC cord-010119-t1x9gknd 7322 17 2 2 CD cord-010119-t1x9gknd 7322 18 ) ) -RRB- cord-010119-t1x9gknd 7323 1 B b NN cord-010119-t1x9gknd 7323 2 antigen antigen NN cord-010119-t1x9gknd 7323 3 to to TO cord-010119-t1x9gknd 7323 4 be be VB cord-010119-t1x9gknd 7323 5 the the DT cord-010119-t1x9gknd 7323 6 underlying underlying JJ cord-010119-t1x9gknd 7323 7 reason reason NN cord-010119-t1x9gknd 7323 8 . . . cord-010119-t1x9gknd 7324 1 Inhibition inhibition NN cord-010119-t1x9gknd 7324 2 with with IN cord-010119-t1x9gknd 7324 3 Lewis Lewis NNP cord-010119-t1x9gknd 7324 4 substance substance NN cord-010119-t1x9gknd 7324 5 significantly significantly RB cord-010119-t1x9gknd 7324 6 decreased decrease VBD cord-010119-t1x9gknd 7324 7 reactivity reactivity NN cord-010119-t1x9gknd 7324 8 . . . cord-010119-t1x9gknd 7325 1 Enzyme enzyme NN cord-010119-t1x9gknd 7325 2 activity activity NN cord-010119-t1x9gknd 7325 3 assay assay NN cord-010119-t1x9gknd 7325 4 showed show VBD cord-010119-t1x9gknd 7325 5 the the DT cord-010119-t1x9gknd 7325 6 patient patient NN cord-010119-t1x9gknd 7325 7 's 's POS cord-010119-t1x9gknd 7325 8 plasma plasma NN cord-010119-t1x9gknd 7325 9 to to TO cord-010119-t1x9gknd 7325 10 contain contain VB cord-010119-t1x9gknd 7325 11 a a DT cord-010119-t1x9gknd 7325 12 fully fully RB cord-010119-t1x9gknd 7325 13 functional functional JJ cord-010119-t1x9gknd 7325 14 B b NN cord-010119-t1x9gknd 7325 15 glycosyltransferase glycosyltransferase NN cord-010119-t1x9gknd 7325 16 . . . cord-010119-t1x9gknd 7326 1 On on IN cord-010119-t1x9gknd 7326 2 the the DT cord-010119-t1x9gknd 7326 3 suspicion suspicion NN cord-010119-t1x9gknd 7326 4 that that IN cord-010119-t1x9gknd 7326 5 the the DT cord-010119-t1x9gknd 7326 6 patient patient NN cord-010119-t1x9gknd 7326 7 had have VBD cord-010119-t1x9gknd 7326 8 non non JJ cord-010119-t1x9gknd 7326 9 - - JJ cord-010119-t1x9gknd 7326 10 erythroid erythroid JJ cord-010119-t1x9gknd 7326 11 cells cell NNS cord-010119-t1x9gknd 7326 12 producing produce VBG cord-010119-t1x9gknd 7326 13 Breactive Breactive NNP cord-010119-t1x9gknd 7326 14 type type NN cord-010119-t1x9gknd 7326 15 1 1 CD cord-010119-t1x9gknd 7326 16 chains chain NNS cord-010119-t1x9gknd 7326 17 , , , cord-010119-t1x9gknd 7326 18 a a DT cord-010119-t1x9gknd 7326 19 sample sample NN cord-010119-t1x9gknd 7326 20 from from IN cord-010119-t1x9gknd 7326 21 a a DT cord-010119-t1x9gknd 7326 22 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 7326 23 stem stem NN cord-010119-t1x9gknd 7326 24 cell cell NN cord-010119-t1x9gknd 7326 25 transplant transplant NN cord-010119-t1x9gknd 7326 26 ( ( -LRB- cord-010119-t1x9gknd 7326 27 HSCT HSCT NNP cord-010119-t1x9gknd 7326 28 ) ) -RRB- cord-010119-t1x9gknd 7326 29 patient patient JJ cord-010119-t1x9gknd 7326 30 ( ( -LRB- cord-010119-t1x9gknd 7326 31 group group NN cord-010119-t1x9gknd 7326 32 B B NNP cord-010119-t1x9gknd 7326 33 secretor secretor NNP cord-010119-t1x9gknd 7326 34 receiving receive VBG cord-010119-t1x9gknd 7326 35 group group NN cord-010119-t1x9gknd 7326 36 O o NN cord-010119-t1x9gknd 7326 37 donor donor NN cord-010119-t1x9gknd 7326 38 cells cell NNS cord-010119-t1x9gknd 7326 39 ) ) -RRB- cord-010119-t1x9gknd 7326 40 was be VBD cord-010119-t1x9gknd 7326 41 included include VBN cord-010119-t1x9gknd 7326 42 as as IN cord-010119-t1x9gknd 7326 43 a a DT cord-010119-t1x9gknd 7326 44 control control NN cord-010119-t1x9gknd 7326 45 and and CC cord-010119-t1x9gknd 7326 46 gave give VBD cord-010119-t1x9gknd 7326 47 the the DT cord-010119-t1x9gknd 7326 48 same same JJ cord-010119-t1x9gknd 7326 49 type type NN cord-010119-t1x9gknd 7326 50 of of IN cord-010119-t1x9gknd 7326 51 reactions reaction NNS cord-010119-t1x9gknd 7326 52 . . . cord-010119-t1x9gknd 7327 1 Conclusion conclusion NN cord-010119-t1x9gknd 7327 2 : : : cord-010119-t1x9gknd 7328 1 The the DT cord-010119-t1x9gknd 7328 2 medical medical JJ cord-010119-t1x9gknd 7328 3 history history NN cord-010119-t1x9gknd 7328 4 of of IN cord-010119-t1x9gknd 7328 5 the the DT cord-010119-t1x9gknd 7328 6 patient patient NN cord-010119-t1x9gknd 7328 7 was be VBD cord-010119-t1x9gknd 7328 8 queried query VBN cord-010119-t1x9gknd 7328 9 and and CC cord-010119-t1x9gknd 7328 10 he -PRON- PRP cord-010119-t1x9gknd 7328 11 had have VBD cord-010119-t1x9gknd 7328 12 indeed indeed RB cord-010119-t1x9gknd 7328 13 undergone undergo VBN cord-010119-t1x9gknd 7328 14 an an DT cord-010119-t1x9gknd 7328 15 HSCT HSCT NNP cord-010119-t1x9gknd 7328 16 $ $ $ cord-010119-t1x9gknd 7328 17 15 15 CD cord-010119-t1x9gknd 7328 18 years year NNS cord-010119-t1x9gknd 7328 19 earlier early RBR cord-010119-t1x9gknd 7328 20 . . . cord-010119-t1x9gknd 7329 1 The the DT cord-010119-t1x9gknd 7329 2 reactions reaction NNS cord-010119-t1x9gknd 7329 3 are be VBP cord-010119-t1x9gknd 7329 4 likely likely JJ cord-010119-t1x9gknd 7329 5 due due IN cord-010119-t1x9gknd 7329 6 to to IN cord-010119-t1x9gknd 7329 7 uptake uptake NN cord-010119-t1x9gknd 7329 8 of of IN cord-010119-t1x9gknd 7329 9 recipient recipient NN cord-010119-t1x9gknd 7329 10 - - HYPH cord-010119-t1x9gknd 7329 11 derived derive VBN cord-010119-t1x9gknd 7329 12 BLe BLe NNS cord-010119-t1x9gknd 7329 13 b b . cord-010119-t1x9gknd 7329 14 ( ( -LRB- cord-010119-t1x9gknd 7329 15 type type NN cord-010119-t1x9gknd 7329 16 1 1 CD cord-010119-t1x9gknd 7329 17 ) ) -RRB- cord-010119-t1x9gknd 7329 18 antigen antigen NN cord-010119-t1x9gknd 7329 19 ( ( -LRB- cord-010119-t1x9gknd 7329 20 ISBT ISBT NNP cord-010119-t1x9gknd 7329 21 no no NN cord-010119-t1x9gknd 7329 22 . . . cord-010119-t1x9gknd 7329 23 007006 007006 CD cord-010119-t1x9gknd 7329 24 ) ) -RRB- cord-010119-t1x9gknd 7329 25 , , , cord-010119-t1x9gknd 7329 26 which which WDT cord-010119-t1x9gknd 7329 27 is be VBZ cord-010119-t1x9gknd 7329 28 the the DT cord-010119-t1x9gknd 7329 29 dominant dominant JJ cord-010119-t1x9gknd 7329 30 Lewis Lewis NNP cord-010119-t1x9gknd 7329 31 antigen antigen NN cord-010119-t1x9gknd 7329 32 in in IN cord-010119-t1x9gknd 7329 33 the the DT cord-010119-t1x9gknd 7329 34 recipient recipient NN cord-010119-t1x9gknd 7329 35 's 's POS cord-010119-t1x9gknd 7329 36 original original JJ cord-010119-t1x9gknd 7329 37 blood blood NN cord-010119-t1x9gknd 7329 38 group group NN cord-010119-t1x9gknd 7329 39 , , , cord-010119-t1x9gknd 7329 40 B B NNP cord-010119-t1x9gknd 7329 41 Le(a Le(a NNP cord-010119-t1x9gknd 7329 42 - - HYPH cord-010119-t1x9gknd 7329 43 b1 b1 NNP cord-010119-t1x9gknd 7329 44 ) ) -RRB- cord-010119-t1x9gknd 7329 45 . . . cord-010119-t1x9gknd 7330 1 Interestingly interestingly RB cord-010119-t1x9gknd 7330 2 , , , cord-010119-t1x9gknd 7330 3 B B NNP cord-010119-t1x9gknd 7330 4 - - HYPH cord-010119-t1x9gknd 7330 5 zyme zyme NNP cord-010119-t1x9gknd 7330 6 did do VBD cord-010119-t1x9gknd 7330 7 not not RB cord-010119-t1x9gknd 7330 8 affect affect VB cord-010119-t1x9gknd 7330 9 BLe BLe NNP cord-010119-t1x9gknd 7330 10 b b NNP cord-010119-t1x9gknd 7330 11 . . . cord-010119-t1x9gknd 7331 1 Anti anti JJ cord-010119-t1x9gknd 7331 2 - - JJ cord-010119-t1x9gknd 7331 3 BLe BLe NNP cord-010119-t1x9gknd 7331 4 b b NNP cord-010119-t1x9gknd 7331 5 is be VBZ cord-010119-t1x9gknd 7331 6 not not RB cord-010119-t1x9gknd 7331 7 simply simply RB cord-010119-t1x9gknd 7331 8 anti anti JJ cord-010119-t1x9gknd 7331 9 - - JJ cord-010119-t1x9gknd 7331 10 B b JJ cord-010119-t1x9gknd 7331 11 plus plus CC cord-010119-t1x9gknd 7331 12 anti anti JJ cord-010119-t1x9gknd 7331 13 - - NNP cord-010119-t1x9gknd 7331 14 Le Le NNP cord-010119-t1x9gknd 7331 15 b b NNP cord-010119-t1x9gknd 7331 16 but but CC cord-010119-t1x9gknd 7331 17 an an DT cord-010119-t1x9gknd 7331 18 inseparable inseparable JJ cord-010119-t1x9gknd 7331 19 and and CC cord-010119-t1x9gknd 7331 20 rarely rarely RB cord-010119-t1x9gknd 7331 21 reported report VBD cord-010119-t1x9gknd 7331 22 specificity specificity NN cord-010119-t1x9gknd 7331 23 , , , cord-010119-t1x9gknd 7331 24 which which WDT cord-010119-t1x9gknd 7331 25 appears appear VBZ cord-010119-t1x9gknd 7331 26 to to TO cord-010119-t1x9gknd 7331 27 be be VB cord-010119-t1x9gknd 7331 28 common common JJ cord-010119-t1x9gknd 7331 29 among among IN cord-010119-t1x9gknd 7331 30 group group NN cord-010119-t1x9gknd 7331 31 O o NN cord-010119-t1x9gknd 7331 32 donors donor NNS cord-010119-t1x9gknd 7331 33 . . . cord-010119-t1x9gknd 7332 1 The the DT cord-010119-t1x9gknd 7332 2 phenomenon phenomenon NN cord-010119-t1x9gknd 7332 3 reported report VBN cord-010119-t1x9gknd 7332 4 here here RB cord-010119-t1x9gknd 7332 5 has have VBZ cord-010119-t1x9gknd 7332 6 unknown unknown JJ cord-010119-t1x9gknd 7332 7 clinical clinical JJ cord-010119-t1x9gknd 7332 8 implications implication NNS cord-010119-t1x9gknd 7332 9 but but CC cord-010119-t1x9gknd 7332 10 highlights highlight VBZ cord-010119-t1x9gknd 7332 11 the the DT cord-010119-t1x9gknd 7332 12 complexities complexity NNS cord-010119-t1x9gknd 7332 13 of of IN cord-010119-t1x9gknd 7332 14 carbohydrate carbohydrate NN cord-010119-t1x9gknd 7332 15 blood blood NN cord-010119-t1x9gknd 7332 16 groups group NNS cord-010119-t1x9gknd 7332 17 . . . cord-010119-t1x9gknd 7333 1 Background Background NNP cord-010119-t1x9gknd 7333 2 / / SYM cord-010119-t1x9gknd 7333 3 Case Case NNP cord-010119-t1x9gknd 7333 4 Studies Studies NNPS cord-010119-t1x9gknd 7333 5 : : : cord-010119-t1x9gknd 7333 6 The the DT cord-010119-t1x9gknd 7333 7 ProVUEV provuev NN cord-010119-t1x9gknd 7333 8 R r NN cord-010119-t1x9gknd 7333 9 and and CC cord-010119-t1x9gknd 7333 10 VisionV visionv NN cord-010119-t1x9gknd 7333 11 R r NN cord-010119-t1x9gknd 7333 12 ( ( -LRB- cord-010119-t1x9gknd 7333 13 Ortho Ortho NNP cord-010119-t1x9gknd 7333 14 Scientific Scientific NNP cord-010119-t1x9gknd 7333 15 , , , cord-010119-t1x9gknd 7333 16 Raritan Raritan NNP cord-010119-t1x9gknd 7333 17 New New NNP cord-010119-t1x9gknd 7333 18 Jersey Jersey NNP cord-010119-t1x9gknd 7333 19 ) ) -RRB- cord-010119-t1x9gknd 7334 1 automated automate VBN cord-010119-t1x9gknd 7334 2 analyzer analyzer NN cord-010119-t1x9gknd 7334 3 use use NN cord-010119-t1x9gknd 7334 4 MTS MTS NNP cord-010119-t1x9gknd 7334 5 - - HYPH cord-010119-t1x9gknd 7334 6 Gel Gel NNP cord-010119-t1x9gknd 7334 7 TM TM NNP cord-010119-t1x9gknd 7334 8 card card NN cord-010119-t1x9gknd 7334 9 technology technology NN cord-010119-t1x9gknd 7334 10 to to TO cord-010119-t1x9gknd 7334 11 perform perform VB cord-010119-t1x9gknd 7334 12 immunohematology immunohematology NN cord-010119-t1x9gknd 7334 13 testing testing NN cord-010119-t1x9gknd 7334 14 . . . cord-010119-t1x9gknd 7335 1 Benefits benefit NNS cord-010119-t1x9gknd 7335 2 of of IN cord-010119-t1x9gknd 7335 3 automated automated JJ cord-010119-t1x9gknd 7335 4 testing testing NN cord-010119-t1x9gknd 7335 5 include include VBP cord-010119-t1x9gknd 7335 6 improved improve VBN cord-010119-t1x9gknd 7335 7 efficiency efficiency NN cord-010119-t1x9gknd 7335 8 and and CC cord-010119-t1x9gknd 7335 9 enhanced enhanced JJ cord-010119-t1x9gknd 7335 10 reliability reliability NN cord-010119-t1x9gknd 7335 11 . . . cord-010119-t1x9gknd 7336 1 After after IN cord-010119-t1x9gknd 7336 2 eight eight CD cord-010119-t1x9gknd 7336 3 years year NNS cord-010119-t1x9gknd 7336 4 of of IN cord-010119-t1x9gknd 7336 5 using use VBG cord-010119-t1x9gknd 7336 6 the the DT cord-010119-t1x9gknd 7336 7 ProVUEV provuev NN cord-010119-t1x9gknd 7336 8 R r NN cord-010119-t1x9gknd 7336 9 our -PRON- PRP$ cord-010119-t1x9gknd 7336 10 Transfusion Transfusion NNP cord-010119-t1x9gknd 7336 11 Medicine Medicine NNP cord-010119-t1x9gknd 7336 12 service service NN cord-010119-t1x9gknd 7336 13 switched switch VBD cord-010119-t1x9gknd 7336 14 to to IN cord-010119-t1x9gknd 7336 15 the the DT cord-010119-t1x9gknd 7336 16 ORTHO ORTHO NNP cord-010119-t1x9gknd 7336 17 VisionV visionv NN cord-010119-t1x9gknd 7336 18 R r NN cord-010119-t1x9gknd 7336 19 analyzer analyzer NN cord-010119-t1x9gknd 7336 20 in in IN cord-010119-t1x9gknd 7336 21 January January NNP cord-010119-t1x9gknd 7336 22 of of IN cord-010119-t1x9gknd 7336 23 2017 2017 CD cord-010119-t1x9gknd 7336 24 . . . cord-010119-t1x9gknd 7337 1 Shortly shortly RB cord-010119-t1x9gknd 7337 2 after after IN cord-010119-t1x9gknd 7337 3 implementation implementation NN cord-010119-t1x9gknd 7337 4 , , , cord-010119-t1x9gknd 7337 5 technologists technologist NNS cord-010119-t1x9gknd 7337 6 reported report VBD cord-010119-t1x9gknd 7337 7 increased increase VBN cord-010119-t1x9gknd 7337 8 time time NN cord-010119-t1x9gknd 7337 9 spent spend VBD cord-010119-t1x9gknd 7337 10 performing perform VBG cord-010119-t1x9gknd 7337 11 manual manual JJ cord-010119-t1x9gknd 7337 12 resolution resolution NN cord-010119-t1x9gknd 7337 13 of of IN cord-010119-t1x9gknd 7337 14 indeterminate indeterminate JJ cord-010119-t1x9gknd 7337 15 ( ( -LRB- cord-010119-t1x9gknd 7337 16 designated designate VBN cord-010119-t1x9gknd 7337 17 as as IN cord-010119-t1x9gknd 7337 18 " " `` cord-010119-t1x9gknd 7337 19 ? ? . cord-010119-t1x9gknd 7337 20 " " '' cord-010119-t1x9gknd 7337 21 ) ) -RRB- cord-010119-t1x9gknd 7337 22 results result NNS cord-010119-t1x9gknd 7337 23 . . . cord-010119-t1x9gknd 7338 1 Additionally additionally RB cord-010119-t1x9gknd 7338 2 , , , cord-010119-t1x9gknd 7338 3 some some DT cord-010119-t1x9gknd 7338 4 test test NN cord-010119-t1x9gknd 7338 5 columns column NNS cord-010119-t1x9gknd 7338 6 were be VBD cord-010119-t1x9gknd 7338 7 noted note VBN cord-010119-t1x9gknd 7338 8 to to TO cord-010119-t1x9gknd 7338 9 be be VB cord-010119-t1x9gknd 7338 10 visually visually RB cord-010119-t1x9gknd 7338 11 negative negative JJ cord-010119-t1x9gknd 7338 12 but but CC cord-010119-t1x9gknd 7338 13 called call VBN cord-010119-t1x9gknd 7338 14 positive positive JJ cord-010119-t1x9gknd 7338 15 ( ( -LRB- cord-010119-t1x9gknd 7338 16 11 11 CD cord-010119-t1x9gknd 7338 17 ) ) -RRB- cord-010119-t1x9gknd 7338 18 by by IN cord-010119-t1x9gknd 7338 19 the the DT cord-010119-t1x9gknd 7338 20 analyzer analyzer NN cord-010119-t1x9gknd 7338 21 . . . cord-010119-t1x9gknd 7339 1 The the DT cord-010119-t1x9gknd 7339 2 objective objective NN cord-010119-t1x9gknd 7339 3 of of IN cord-010119-t1x9gknd 7339 4 this this DT cord-010119-t1x9gknd 7339 5 study study NN cord-010119-t1x9gknd 7339 6 was be VBD cord-010119-t1x9gknd 7339 7 to to TO cord-010119-t1x9gknd 7339 8 investigate investigate VB cord-010119-t1x9gknd 7339 9 the the DT cord-010119-t1x9gknd 7339 10 cause cause NN cord-010119-t1x9gknd 7339 11 of of IN cord-010119-t1x9gknd 7339 12 " " `` cord-010119-t1x9gknd 7339 13 ? ? . cord-010119-t1x9gknd 7339 14 " " '' cord-010119-t1x9gknd 7339 15 and and CC cord-010119-t1x9gknd 7339 16 apparent apparent JJ cord-010119-t1x9gknd 7339 17 false false JJ cord-010119-t1x9gknd 7339 18 positive positive JJ cord-010119-t1x9gknd 7339 19 results result NNS cord-010119-t1x9gknd 7339 20 on on IN cord-010119-t1x9gknd 7339 21 VisionV visionv NN cord-010119-t1x9gknd 7339 22 R R NNP cord-010119-t1x9gknd 7339 23 three three CD cord-010119-t1x9gknd 7339 24 - - HYPH cord-010119-t1x9gknd 7339 25 cell cell NN cord-010119-t1x9gknd 7339 26 antibody antibody NN cord-010119-t1x9gknd 7339 27 screens screen NNS cord-010119-t1x9gknd 7339 28 . . . cord-010119-t1x9gknd 7340 1 Study Study NNP cord-010119-t1x9gknd 7340 2 Design Design NNP cord-010119-t1x9gknd 7340 3 / / SYM cord-010119-t1x9gknd 7340 4 Methods method NNS cord-010119-t1x9gknd 7340 5 : : : cord-010119-t1x9gknd 7340 6 With with IN cord-010119-t1x9gknd 7340 7 assistance assistance NN cord-010119-t1x9gknd 7340 8 from from IN cord-010119-t1x9gknd 7340 9 Ortho Ortho NNP cord-010119-t1x9gknd 7340 10 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 7340 11 , , , cord-010119-t1x9gknd 7340 12 analyzer analyzer NN cord-010119-t1x9gknd 7340 13 archives archive NNS cord-010119-t1x9gknd 7340 14 were be VBD cord-010119-t1x9gknd 7340 15 queried query VBN cord-010119-t1x9gknd 7340 16 to to TO cord-010119-t1x9gknd 7340 17 identify identify VB cord-010119-t1x9gknd 7340 18 the the DT cord-010119-t1x9gknd 7340 19 number number NN cord-010119-t1x9gknd 7340 20 of of IN cord-010119-t1x9gknd 7340 21 gel gel NN cord-010119-t1x9gknd 7340 22 card card NN cord-010119-t1x9gknd 7340 23 columns column NNS cord-010119-t1x9gknd 7340 24 used use VBN cord-010119-t1x9gknd 7340 25 for for IN cord-010119-t1x9gknd 7340 26 screens screen NNS cord-010119-t1x9gknd 7340 27 , , , cord-010119-t1x9gknd 7340 28 the the DT cord-010119-t1x9gknd 7340 29 number number NN cord-010119-t1x9gknd 7340 30 of of IN cord-010119-t1x9gknd 7340 31 columns column NNS cord-010119-t1x9gknd 7340 32 with with IN cord-010119-t1x9gknd 7340 33 " " `` cord-010119-t1x9gknd 7340 34 ? ? . cord-010119-t1x9gknd 7340 35 " " '' cord-010119-t1x9gknd 7340 36 results result NNS cord-010119-t1x9gknd 7340 37 , , , cord-010119-t1x9gknd 7340 38 and and CC cord-010119-t1x9gknd 7340 39 the the DT cord-010119-t1x9gknd 7340 40 gel gel NN cord-010119-t1x9gknd 7340 41 card card NN cord-010119-t1x9gknd 7340 42 lot lot NN cord-010119-t1x9gknd 7340 43 numbers number NNS cord-010119-t1x9gknd 7340 44 used use VBN cord-010119-t1x9gknd 7340 45 for for IN cord-010119-t1x9gknd 7340 46 testing testing NN cord-010119-t1x9gknd 7340 47 from from IN cord-010119-t1x9gknd 7340 48 1/29/2017 1/29/2017 CD cord-010119-t1x9gknd 7340 49 to to IN cord-010119-t1x9gknd 7340 50 3/31/2017 3/31/2017 CD cord-010119-t1x9gknd 7340 51 . . . cord-010119-t1x9gknd 7341 1 Reactivity reactivity NN cord-010119-t1x9gknd 7341 2 was be VBD cord-010119-t1x9gknd 7341 3 determined determine VBN cord-010119-t1x9gknd 7341 4 to to TO cord-010119-t1x9gknd 7341 5 be be VB cord-010119-t1x9gknd 7341 6 false false JJ cord-010119-t1x9gknd 7341 7 positive positive JJ cord-010119-t1x9gknd 7341 8 based base VBN cord-010119-t1x9gknd 7341 9 on on IN cord-010119-t1x9gknd 7341 10 supervisory supervisory JJ cord-010119-t1x9gknd 7341 11 review review NN cord-010119-t1x9gknd 7341 12 of of IN cord-010119-t1x9gknd 7341 13 digital digital JJ cord-010119-t1x9gknd 7341 14 images image NNS cord-010119-t1x9gknd 7341 15 and and CC cord-010119-t1x9gknd 7341 16 antibody antibody NN cord-010119-t1x9gknd 7341 17 panel panel NN cord-010119-t1x9gknd 7341 18 results result NNS cord-010119-t1x9gknd 7341 19 . . . cord-010119-t1x9gknd 7342 1 Investigation investigation NN cord-010119-t1x9gknd 7342 2 also also RB cord-010119-t1x9gknd 7342 3 included include VBD cord-010119-t1x9gknd 7342 4 review review NN cord-010119-t1x9gknd 7342 5 of of IN cord-010119-t1x9gknd 7342 6 daily daily JJ cord-010119-t1x9gknd 7342 7 QC QC NNP cord-010119-t1x9gknd 7342 8 records record NNS cord-010119-t1x9gknd 7342 9 , , , cord-010119-t1x9gknd 7342 10 instrument instrument NN cord-010119-t1x9gknd 7342 11 maintenance maintenance NN cord-010119-t1x9gknd 7342 12 , , , cord-010119-t1x9gknd 7342 13 instrument instrument NN cord-010119-t1x9gknd 7342 14 diagnostics diagnostic NNS cord-010119-t1x9gknd 7342 15 , , , cord-010119-t1x9gknd 7342 16 and and CC cord-010119-t1x9gknd 7342 17 camera camera NN cord-010119-t1x9gknd 7342 18 calibration calibration NN cord-010119-t1x9gknd 7342 19 . . . cord-010119-t1x9gknd 7343 1 Results result NNS cord-010119-t1x9gknd 7343 2 / / SYM cord-010119-t1x9gknd 7343 3 Findings finding NNS cord-010119-t1x9gknd 7343 4 : : : cord-010119-t1x9gknd 7344 1 Of of IN cord-010119-t1x9gknd 7344 2 19,647 19,647 CD cord-010119-t1x9gknd 7344 3 columns column NNS cord-010119-t1x9gknd 7344 4 run run VBN cord-010119-t1x9gknd 7344 5 as as IN cord-010119-t1x9gknd 7344 6 part part NN cord-010119-t1x9gknd 7344 7 of of IN cord-010119-t1x9gknd 7344 8 antibody antibody NN cord-010119-t1x9gknd 7344 9 screens screen NNS cord-010119-t1x9gknd 7344 10 , , , cord-010119-t1x9gknd 7344 11 1,633 1,633 CD cord-010119-t1x9gknd 7344 12 ( ( -LRB- cord-010119-t1x9gknd 7344 13 8.3 8.3 CD cord-010119-t1x9gknd 7344 14 % % NN cord-010119-t1x9gknd 7344 15 ) ) -RRB- cord-010119-t1x9gknd 7344 16 columns column NNS cord-010119-t1x9gknd 7344 17 generated generate VBN cord-010119-t1x9gknd 7344 18 " " '' cord-010119-t1x9gknd 7344 19 ? ? . cord-010119-t1x9gknd 7345 1 " " `` cord-010119-t1x9gknd 7345 2 results result NNS cord-010119-t1x9gknd 7345 3 . . . cord-010119-t1x9gknd 7346 1 Assuming assume VBG cord-010119-t1x9gknd 7346 2 30 30 CD cord-010119-t1x9gknd 7346 3 seconds second NNS cord-010119-t1x9gknd 7346 4 of of IN cord-010119-t1x9gknd 7346 5 technologist technologist NN cord-010119-t1x9gknd 7346 6 time time NN cord-010119-t1x9gknd 7346 7 per per IN cord-010119-t1x9gknd 7346 8 " " '' cord-010119-t1x9gknd 7346 9 ? ? . cord-010119-t1x9gknd 7346 10 " " '' cord-010119-t1x9gknd 7346 11 , , , cord-010119-t1x9gknd 7346 12 we -PRON- PRP cord-010119-t1x9gknd 7346 13 estimate estimate VBP cord-010119-t1x9gknd 7346 14 that that IN cord-010119-t1x9gknd 7346 15 13.6 13.6 CD cord-010119-t1x9gknd 7346 16 hours hour NNS cord-010119-t1x9gknd 7346 17 were be VBD cord-010119-t1x9gknd 7346 18 needed need VBN cord-010119-t1x9gknd 7346 19 to to TO cord-010119-t1x9gknd 7346 20 resolve resolve VB cord-010119-t1x9gknd 7346 21 and and CC cord-010119-t1x9gknd 7346 22 update update VB cord-010119-t1x9gknd 7346 23 these these DT cord-010119-t1x9gknd 7346 24 results result NNS cord-010119-t1x9gknd 7346 25 . . . cord-010119-t1x9gknd 7347 1 Among among IN cord-010119-t1x9gknd 7347 2 all all DT cord-010119-t1x9gknd 7347 3 potential potential JJ cord-010119-t1x9gknd 7347 4 causes cause NNS cord-010119-t1x9gknd 7347 5 investigated investigate VBN cord-010119-t1x9gknd 7347 6 , , , cord-010119-t1x9gknd 7347 7 only only RB cord-010119-t1x9gknd 7347 8 the the DT cord-010119-t1x9gknd 7347 9 gel gel NN cord-010119-t1x9gknd 7347 10 card card NN cord-010119-t1x9gknd 7347 11 lot lot NN cord-010119-t1x9gknd 7347 12 number number NN cord-010119-t1x9gknd 7347 13 was be VBD cord-010119-t1x9gknd 7347 14 associated associate VBN cord-010119-t1x9gknd 7347 15 with with IN cord-010119-t1x9gknd 7347 16 the the DT cord-010119-t1x9gknd 7347 17 number number NN cord-010119-t1x9gknd 7347 18 of of IN cord-010119-t1x9gknd 7347 19 " " `` cord-010119-t1x9gknd 7347 20 ? ? . cord-010119-t1x9gknd 7347 21 " " '' cord-010119-t1x9gknd 7347 22 generated generate VBN cord-010119-t1x9gknd 7347 23 ( ( -LRB- cord-010119-t1x9gknd 7347 24 table table NN cord-010119-t1x9gknd 7347 25 1 1 CD cord-010119-t1x9gknd 7347 26 ) ) -RRB- cord-010119-t1x9gknd 7347 27 . . . cord-010119-t1x9gknd 7348 1 In in IN cord-010119-t1x9gknd 7348 2 26 26 CD cord-010119-t1x9gknd 7348 3 cases case NNS cord-010119-t1x9gknd 7348 4 , , , cord-010119-t1x9gknd 7348 5 all all DT cord-010119-t1x9gknd 7348 6 three three CD cord-010119-t1x9gknd 7348 7 columns column NNS cord-010119-t1x9gknd 7348 8 were be VBD cord-010119-t1x9gknd 7348 9 visually visually RB cord-010119-t1x9gknd 7348 10 negative negative JJ cord-010119-t1x9gknd 7348 11 but but CC cord-010119-t1x9gknd 7348 12 the the DT cord-010119-t1x9gknd 7348 13 analyzer analyzer NN cord-010119-t1x9gknd 7348 14 reported report VBD cord-010119-t1x9gknd 7348 15 11 11 CD cord-010119-t1x9gknd 7348 16 reactivity reactivity NN cord-010119-t1x9gknd 7348 17 with with IN cord-010119-t1x9gknd 7348 18 1 1 CD cord-010119-t1x9gknd 7348 19 of of IN cord-010119-t1x9gknd 7348 20 3 3 CD cord-010119-t1x9gknd 7348 21 cells cell NNS cord-010119-t1x9gknd 7348 22 . . . cord-010119-t1x9gknd 7349 1 All all DT cord-010119-t1x9gknd 7349 2 cases case NNS cord-010119-t1x9gknd 7349 3 had have VBD cord-010119-t1x9gknd 7349 4 MTS MTS NNP cord-010119-t1x9gknd 7349 5 - - HYPH cord-010119-t1x9gknd 7349 6 Gel Gel NNP cord-010119-t1x9gknd 7349 7 TM TM NNP cord-010119-t1x9gknd 7349 8 antibody antibody NN cord-010119-t1x9gknd 7349 9 identification identification NN cord-010119-t1x9gknd 7349 10 panels panel NNS cord-010119-t1x9gknd 7349 11 performed perform VBN cord-010119-t1x9gknd 7349 12 , , , cord-010119-t1x9gknd 7349 13 25 25 CD cord-010119-t1x9gknd 7349 14 of of IN cord-010119-t1x9gknd 7349 15 26 26 CD cord-010119-t1x9gknd 7349 16 also also RB cord-010119-t1x9gknd 7349 17 had have VBD cord-010119-t1x9gknd 7349 18 a a DT cord-010119-t1x9gknd 7349 19 MTS MTS NNP cord-010119-t1x9gknd 7349 20 - - HYPH cord-010119-t1x9gknd 7349 21 Gel Gel NNP cord-010119-t1x9gknd 7349 22 TM TM NNP cord-010119-t1x9gknd 7349 23 ficin ficin NNS cord-010119-t1x9gknd 7349 24 panel panel NN cord-010119-t1x9gknd 7349 25 . . . cord-010119-t1x9gknd 7350 1 The the DT cord-010119-t1x9gknd 7350 2 yield yield NN cord-010119-t1x9gknd 7350 3 for for IN cord-010119-t1x9gknd 7350 4 the the DT cord-010119-t1x9gknd 7350 5 51 51 CD cord-010119-t1x9gknd 7350 6 panels panel NNS cord-010119-t1x9gknd 7350 7 performed perform VBN cord-010119-t1x9gknd 7350 8 was be VBD cord-010119-t1x9gknd 7350 9 two two CD cord-010119-t1x9gknd 7350 10 routine routine JJ cord-010119-t1x9gknd 7350 11 panels panel NNS cord-010119-t1x9gknd 7350 12 with with IN cord-010119-t1x9gknd 7350 13 weak weak JJ cord-010119-t1x9gknd 7350 14 reactivity reactivity NN cord-010119-t1x9gknd 7350 15 against against IN cord-010119-t1x9gknd 7350 16 HLA1 HLA1 NNP cord-010119-t1x9gknd 7350 17 cells cell NNS cord-010119-t1x9gknd 7350 18 , , , cord-010119-t1x9gknd 7350 19 and and CC cord-010119-t1x9gknd 7350 20 four four CD cord-010119-t1x9gknd 7350 21 ficin ficin NNS cord-010119-t1x9gknd 7350 22 panels panel NNS cord-010119-t1x9gknd 7350 23 with with IN cord-010119-t1x9gknd 7350 24 weak weak JJ cord-010119-t1x9gknd 7350 25 reactivity reactivity NN cord-010119-t1x9gknd 7350 26 with with IN cord-010119-t1x9gknd 7350 27 no no DT cord-010119-t1x9gknd 7350 28 apparent apparent JJ cord-010119-t1x9gknd 7350 29 specificity specificity NN cord-010119-t1x9gknd 7350 30 . . . cord-010119-t1x9gknd 7351 1 Fourteen fourteen CD cord-010119-t1x9gknd 7351 2 patients patient NNS cord-010119-t1x9gknd 7351 3 coincidentally coincidentally RB cord-010119-t1x9gknd 7351 4 had have VBD cord-010119-t1x9gknd 7351 5 a a DT cord-010119-t1x9gknd 7351 6 subsequent subsequent JJ cord-010119-t1x9gknd 7351 7 Type type NN cord-010119-t1x9gknd 7351 8 and and CC cord-010119-t1x9gknd 7351 9 Screen screen NN cord-010119-t1x9gknd 7351 10 ; ; : cord-010119-t1x9gknd 7351 11 13 13 CD cord-010119-t1x9gknd 7351 12 were be VBD cord-010119-t1x9gknd 7351 13 negative negative JJ cord-010119-t1x9gknd 7351 14 . . . cord-010119-t1x9gknd 7352 1 One one CD cord-010119-t1x9gknd 7352 2 patient patient NN cord-010119-t1x9gknd 7352 3 newly newly RB cord-010119-t1x9gknd 7352 4 demonstrated demonstrate VBN cord-010119-t1x9gknd 7352 5 anti anti JJ cord-010119-t1x9gknd 7352 6 - - NNP cord-010119-t1x9gknd 7352 7 Jka Jka NNP cord-010119-t1x9gknd 7352 8 . . . cord-010119-t1x9gknd 7353 1 Fifty fifty CD cord-010119-t1x9gknd 7353 2 percent percent NN cord-010119-t1x9gknd 7353 3 ( ( -LRB- cord-010119-t1x9gknd 7353 4 13/26 13/26 CD cord-010119-t1x9gknd 7353 5 ) ) -RRB- cord-010119-t1x9gknd 7353 6 of of IN cord-010119-t1x9gknd 7353 7 visually visually RB cord-010119-t1x9gknd 7353 8 negative negative JJ cord-010119-t1x9gknd 7353 9 but but CC cord-010119-t1x9gknd 7353 10 analyzer analyzer VBP cord-010119-t1x9gknd 7353 11 positive positive JJ cord-010119-t1x9gknd 7353 12 samples sample NNS cord-010119-t1x9gknd 7353 13 were be VBD cord-010119-t1x9gknd 7353 14 tested test VBN cord-010119-t1x9gknd 7353 15 with with IN cord-010119-t1x9gknd 7353 16 gel gel NN cord-010119-t1x9gknd 7353 17 card card NN cord-010119-t1x9gknd 7353 18 lot lot NN cord-010119-t1x9gknd 7353 19 number number NN cord-010119-t1x9gknd 7353 20 3 3 CD cord-010119-t1x9gknd 7353 21 , , , cord-010119-t1x9gknd 7353 22 38 38 CD cord-010119-t1x9gknd 7353 23 % % NN cord-010119-t1x9gknd 7353 24 ( ( -LRB- cord-010119-t1x9gknd 7353 25 10/26 10/26 CD cord-010119-t1x9gknd 7353 26 ) ) -RRB- cord-010119-t1x9gknd 7353 27 with with IN cord-010119-t1x9gknd 7353 28 lot lot NN cord-010119-t1x9gknd 7353 29 1 1 CD cord-010119-t1x9gknd 7353 30 , , , cord-010119-t1x9gknd 7353 31 and and CC cord-010119-t1x9gknd 7353 32 12 12 CD cord-010119-t1x9gknd 7353 33 % % NN cord-010119-t1x9gknd 7353 34 ( ( -LRB- cord-010119-t1x9gknd 7353 35 3/ 3/ CD cord-010119-t1x9gknd 7353 36 26 26 CD cord-010119-t1x9gknd 7353 37 ) ) -RRB- cord-010119-t1x9gknd 7353 38 with with IN cord-010119-t1x9gknd 7353 39 lot lot NN cord-010119-t1x9gknd 7353 40 2 2 CD cord-010119-t1x9gknd 7353 41 . . . cord-010119-t1x9gknd 7354 1 Conclusion conclusion NN cord-010119-t1x9gknd 7354 2 : : : cord-010119-t1x9gknd 7355 1 The the DT cord-010119-t1x9gknd 7355 2 incidence incidence NN cord-010119-t1x9gknd 7355 3 of of IN cord-010119-t1x9gknd 7355 4 " " `` cord-010119-t1x9gknd 7355 5 ? ? . cord-010119-t1x9gknd 7355 6 " " '' cord-010119-t1x9gknd 7355 7 and and CC cord-010119-t1x9gknd 7355 8 visually visually RB cord-010119-t1x9gknd 7355 9 negative negative JJ cord-010119-t1x9gknd 7355 10 analyzer analyzer NN cord-010119-t1x9gknd 7355 11 positive positive JJ cord-010119-t1x9gknd 7355 12 results result NNS cord-010119-t1x9gknd 7355 13 is be VBZ cord-010119-t1x9gknd 7355 14 dependent dependent JJ cord-010119-t1x9gknd 7355 15 on on IN cord-010119-t1x9gknd 7355 16 the the DT cord-010119-t1x9gknd 7355 17 specific specific JJ cord-010119-t1x9gknd 7355 18 lot lot NN cord-010119-t1x9gknd 7355 19 of of IN cord-010119-t1x9gknd 7355 20 MTS MTS NNP cord-010119-t1x9gknd 7355 21 - - HYPH cord-010119-t1x9gknd 7355 22 Gel Gel NNP cord-010119-t1x9gknd 7355 23 TM TM NNP cord-010119-t1x9gknd 7355 24 cards card NNS cord-010119-t1x9gknd 7355 25 used use VBN cord-010119-t1x9gknd 7355 26 . . . cord-010119-t1x9gknd 7356 1 The the DT cord-010119-t1x9gknd 7356 2 difference difference NN cord-010119-t1x9gknd 7356 3 between between IN cord-010119-t1x9gknd 7356 4 the the DT cord-010119-t1x9gknd 7356 5 lots lot NNS cord-010119-t1x9gknd 7356 6 is be VBZ cord-010119-t1x9gknd 7356 7 being be VBG cord-010119-t1x9gknd 7356 8 investigated investigate VBN cord-010119-t1x9gknd 7356 9 by by IN cord-010119-t1x9gknd 7356 10 Ortho Ortho NNP cord-010119-t1x9gknd 7356 11 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 7356 12 , , , cord-010119-t1x9gknd 7356 13 and and CC cord-010119-t1x9gknd 7356 14 remains remain VBZ cord-010119-t1x9gknd 7356 15 to to TO cord-010119-t1x9gknd 7356 16 be be VB cord-010119-t1x9gknd 7356 17 explained explain VBN cord-010119-t1x9gknd 7356 18 . . . cord-010119-t1x9gknd 7357 1 To to TO cord-010119-t1x9gknd 7357 2 avoid avoid VB cord-010119-t1x9gknd 7357 3 unnecessary unnecessary JJ cord-010119-t1x9gknd 7357 4 waste waste NN cord-010119-t1x9gknd 7357 5 of of IN cord-010119-t1x9gknd 7357 6 technologist technologist NN cord-010119-t1x9gknd 7357 7 time time NN cord-010119-t1x9gknd 7357 8 and and CC cord-010119-t1x9gknd 7357 9 other other JJ cord-010119-t1x9gknd 7357 10 resources resource NNS cord-010119-t1x9gknd 7357 11 , , , cord-010119-t1x9gknd 7357 12 with with IN cord-010119-t1x9gknd 7357 13 assistance assistance NN cord-010119-t1x9gknd 7357 14 from from IN cord-010119-t1x9gknd 7357 15 Ortho Ortho NNP cord-010119-t1x9gknd 7357 16 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 7357 17 , , , cord-010119-t1x9gknd 7357 18 we -PRON- PRP cord-010119-t1x9gknd 7357 19 have have VBP cord-010119-t1x9gknd 7357 20 Results result NNS cord-010119-t1x9gknd 7358 1 /Finding /finde VBG cord-010119-t1x9gknd 7358 2 : : : cord-010119-t1x9gknd 7358 3 Of of IN cord-010119-t1x9gknd 7358 4 the the DT cord-010119-t1x9gknd 7358 5 methods method NNS cord-010119-t1x9gknd 7358 6 evaluated evaluate VBN cord-010119-t1x9gknd 7358 7 , , , cord-010119-t1x9gknd 7358 8 the the DT cord-010119-t1x9gknd 7358 9 DTT DTT NNP cord-010119-t1x9gknd 7358 10 method method NN cord-010119-t1x9gknd 7358 11 proved prove VBD cord-010119-t1x9gknd 7358 12 the the DT cord-010119-t1x9gknd 7358 13 most most RBS cord-010119-t1x9gknd 7358 14 useful useful JJ cord-010119-t1x9gknd 7358 15 for for IN cord-010119-t1x9gknd 7358 16 mitigating mitigate VBG cord-010119-t1x9gknd 7358 17 DARA DARA NNP cord-010119-t1x9gknd 7358 18 interference interference NN cord-010119-t1x9gknd 7358 19 . . . cord-010119-t1x9gknd 7359 1 Cord cord NN cord-010119-t1x9gknd 7359 2 cells cell NNS cord-010119-t1x9gknd 7359 3 were be VBD cord-010119-t1x9gknd 7359 4 effective effective JJ cord-010119-t1x9gknd 7359 5 but but CC cord-010119-t1x9gknd 7359 6 in in IN cord-010119-t1x9gknd 7359 7 limited limited JJ cord-010119-t1x9gknd 7359 8 supply supply NN cord-010119-t1x9gknd 7359 9 and and CC cord-010119-t1x9gknd 7359 10 alloadsorption alloadsorption NN cord-010119-t1x9gknd 7359 11 was be VBD cord-010119-t1x9gknd 7359 12 ineffective ineffective JJ cord-010119-t1x9gknd 7359 13 . . . cord-010119-t1x9gknd 7360 1 Of of IN cord-010119-t1x9gknd 7360 2 the the DT cord-010119-t1x9gknd 7360 3 three three CD cord-010119-t1x9gknd 7360 4 different different JJ cord-010119-t1x9gknd 7360 5 DTT DTT NNP cord-010119-t1x9gknd 7360 6 methods method NNS cord-010119-t1x9gknd 7360 7 evaluated evaluate VBN cord-010119-t1x9gknd 7360 8 , , , cord-010119-t1x9gknd 7360 9 the the DT cord-010119-t1x9gknd 7360 10 tube tube NN cord-010119-t1x9gknd 7360 11 method method NN cord-010119-t1x9gknd 7360 12 initially initially RB cord-010119-t1x9gknd 7360 13 failed fail VBD cord-010119-t1x9gknd 7360 14 which which WDT cord-010119-t1x9gknd 7360 15 led lead VBD cord-010119-t1x9gknd 7360 16 to to IN cord-010119-t1x9gknd 7360 17 re re NN cord-010119-t1x9gknd 7360 18 - - NN cord-010119-t1x9gknd 7360 19 evaluation evaluation NN cord-010119-t1x9gknd 7360 20 with with IN cord-010119-t1x9gknd 7360 21 the the DT cord-010119-t1x9gknd 7360 22 addition addition NN cord-010119-t1x9gknd 7360 23 of of IN cord-010119-t1x9gknd 7360 24 LISS LISS NNP cord-010119-t1x9gknd 7360 25 ( ( -LRB- cord-010119-t1x9gknd 7360 26 passed pass VBN cord-010119-t1x9gknd 7360 27 ) ) -RRB- cord-010119-t1x9gknd 7360 28 . . . cord-010119-t1x9gknd 7361 1 The the DT cord-010119-t1x9gknd 7361 2 GC GC NNP cord-010119-t1x9gknd 7361 3 method method NN cord-010119-t1x9gknd 7361 4 was be VBD cord-010119-t1x9gknd 7361 5 the the DT cord-010119-t1x9gknd 7361 6 most most RBS cord-010119-t1x9gknd 7361 7 sensitive sensitive JJ cord-010119-t1x9gknd 7361 8 method method NN cord-010119-t1x9gknd 7361 9 . . . cord-010119-t1x9gknd 7362 1 Following follow VBG cord-010119-t1x9gknd 7362 2 release release NN cord-010119-t1x9gknd 7362 3 of of IN cord-010119-t1x9gknd 7362 4 DARA DARA NNP cord-010119-t1x9gknd 7362 5 , , , cord-010119-t1x9gknd 7362 6 samples sample NNS cord-010119-t1x9gknd 7362 7 from from IN cord-010119-t1x9gknd 7362 8 28 28 CD cord-010119-t1x9gknd 7362 9 patients patient NNS cord-010119-t1x9gknd 7362 10 ( ( -LRB- cord-010119-t1x9gknd 7362 11 137 137 CD cord-010119-t1x9gknd 7362 12 cross cross JJ cord-010119-t1x9gknd 7362 13 - - JJ cord-010119-t1x9gknd 7362 14 match match JJ cord-010119-t1x9gknd 7362 15 samples sample NNS cord-010119-t1x9gknd 7362 16 , , , cord-010119-t1x9gknd 7362 17 301 301 CD cord-010119-t1x9gknd 7362 18 units unit NNS cord-010119-t1x9gknd 7362 19 issued issue VBN cord-010119-t1x9gknd 7362 20 ) ) -RRB- cord-010119-t1x9gknd 7362 21 were be VBD cord-010119-t1x9gknd 7362 22 tested test VBN cord-010119-t1x9gknd 7362 23 using use VBG cord-010119-t1x9gknd 7362 24 both both DT cord-010119-t1x9gknd 7362 25 LISS LISS NNP cord-010119-t1x9gknd 7362 26 tube tube NN cord-010119-t1x9gknd 7362 27 and and CC cord-010119-t1x9gknd 7362 28 GC GC NNP cord-010119-t1x9gknd 7362 29 IAT IAT NNP cord-010119-t1x9gknd 7362 30 methods method NNS cord-010119-t1x9gknd 7362 31 . . . cord-010119-t1x9gknd 7363 1 Despite despite IN cord-010119-t1x9gknd 7363 2 DTT DTT NNP cord-010119-t1x9gknd 7363 3 treatment treatment NN cord-010119-t1x9gknd 7363 4 , , , cord-010119-t1x9gknd 7363 5 the the DT cord-010119-t1x9gknd 7363 6 GC GC NNP cord-010119-t1x9gknd 7363 7 method method NN cord-010119-t1x9gknd 7363 8 remained remain VBD cord-010119-t1x9gknd 7363 9 positive positive JJ cord-010119-t1x9gknd 7363 10 by by IN cord-010119-t1x9gknd 7363 11 IAT IAT NNP cord-010119-t1x9gknd 7363 12 in in IN cord-010119-t1x9gknd 7363 13 16/28 16/28 CD cord-010119-t1x9gknd 7363 14 patients patient NNS cord-010119-t1x9gknd 7363 15 . . . cord-010119-t1x9gknd 7364 1 Further further JJ cord-010119-t1x9gknd 7364 2 testing testing NN cord-010119-t1x9gknd 7364 3 was be VBD cord-010119-t1x9gknd 7364 4 performed perform VBN cord-010119-t1x9gknd 7364 5 in in IN cord-010119-t1x9gknd 7364 6 9/16 9/16 CD cord-010119-t1x9gknd 7364 7 . . . cord-010119-t1x9gknd 7365 1 Eight eight CD cord-010119-t1x9gknd 7365 2 were be VBD cord-010119-t1x9gknd 7365 3 tested test VBN cord-010119-t1x9gknd 7365 4 for for IN cord-010119-t1x9gknd 7365 5 the the DT cord-010119-t1x9gknd 7365 6 presence presence NN cord-010119-t1x9gknd 7365 7 of of IN cord-010119-t1x9gknd 7365 8 antibodies antibody NNS cord-010119-t1x9gknd 7365 9 at at IN cord-010119-t1x9gknd 7365 10 188C 188c CD cord-010119-t1x9gknd 7365 11 and and CC cord-010119-t1x9gknd 7365 12 confirmed confirm VBD cord-010119-t1x9gknd 7365 13 in in IN cord-010119-t1x9gknd 7365 14 8/8 8/8 CD cord-010119-t1x9gknd 7365 15 . . . cord-010119-t1x9gknd 7366 1 Rouleaux Rouleaux NNP cord-010119-t1x9gknd 7366 2 formation formation NN cord-010119-t1x9gknd 7366 3 was be VBD cord-010119-t1x9gknd 7366 4 observed observe VBN cord-010119-t1x9gknd 7366 5 in in IN cord-010119-t1x9gknd 7366 6 5/9 5/9 CD cord-010119-t1x9gknd 7366 7 patients patient NNS cord-010119-t1x9gknd 7366 8 , , , cord-010119-t1x9gknd 7366 9 4/5 4/5 CD cord-010119-t1x9gknd 7366 10 had have VBD cord-010119-t1x9gknd 7366 11 reactivity reactivity NN cord-010119-t1x9gknd 7366 12 detectable detectable JJ cord-010119-t1x9gknd 7366 13 at at IN cord-010119-t1x9gknd 7366 14 188C. 188c. CD cord-010119-t1x9gknd 7367 1 No no DT cord-010119-t1x9gknd 7367 2 transfusion transfusion NN cord-010119-t1x9gknd 7367 3 reactions reaction NNS cord-010119-t1x9gknd 7367 4 have have VBP cord-010119-t1x9gknd 7367 5 been be VBN cord-010119-t1x9gknd 7367 6 reported report VBN cord-010119-t1x9gknd 7367 7 to to IN cord-010119-t1x9gknd 7367 8 date date NN cord-010119-t1x9gknd 7367 9 nor nor CC cord-010119-t1x9gknd 7367 10 has have VBZ cord-010119-t1x9gknd 7367 11 alloantibody alloantibody NN cord-010119-t1x9gknd 7367 12 formation formation NN cord-010119-t1x9gknd 7367 13 been be VBN cord-010119-t1x9gknd 7367 14 observed observe VBN cord-010119-t1x9gknd 7367 15 to to IN cord-010119-t1x9gknd 7367 16 date date NN cord-010119-t1x9gknd 7367 17 . . . cord-010119-t1x9gknd 7368 1 Conclusion conclusion NN cord-010119-t1x9gknd 7368 2 : : : cord-010119-t1x9gknd 7369 1 As as IN cord-010119-t1x9gknd 7369 2 previously previously RB cord-010119-t1x9gknd 7369 3 reported report VBN cord-010119-t1x9gknd 7369 4 , , , cord-010119-t1x9gknd 7369 5 the the DT cord-010119-t1x9gknd 7369 6 DTT DTT NNP cord-010119-t1x9gknd 7369 7 method method NN cord-010119-t1x9gknd 7369 8 was be VBD cord-010119-t1x9gknd 7369 9 the the DT cord-010119-t1x9gknd 7369 10 most most RBS cord-010119-t1x9gknd 7369 11 useful useful JJ cord-010119-t1x9gknd 7369 12 for for IN cord-010119-t1x9gknd 7369 13 mitigating mitigate VBG cord-010119-t1x9gknd 7369 14 DARA DARA NNP cord-010119-t1x9gknd 7369 15 interference interference NN cord-010119-t1x9gknd 7369 16 . . . cord-010119-t1x9gknd 7370 1 The the DT cord-010119-t1x9gknd 7370 2 observed observed JJ cord-010119-t1x9gknd 7370 3 interference interference NN cord-010119-t1x9gknd 7370 4 seems seem VBZ cord-010119-t1x9gknd 7370 5 to to TO cord-010119-t1x9gknd 7370 6 be be VB cord-010119-t1x9gknd 7370 7 due due JJ cord-010119-t1x9gknd 7370 8 to to IN cord-010119-t1x9gknd 7370 9 rouleaux rouleaux JJ cord-010119-t1x9gknd 7370 10 and/or and/or CC cord-010119-t1x9gknd 7370 11 cold cold JJ cord-010119-t1x9gknd 7370 12 reactive reactive JJ cord-010119-t1x9gknd 7370 13 antibodies antibody NNS cord-010119-t1x9gknd 7370 14 -seen -seen VBD cord-010119-t1x9gknd 7370 15 least least JJS cord-010119-t1x9gknd 7370 16 in in IN cord-010119-t1x9gknd 7370 17 the the DT cord-010119-t1x9gknd 7370 18 LISS LISS NNP cord-010119-t1x9gknd 7370 19 tube tube NN cord-010119-t1x9gknd 7370 20 IAT IAT NNP cord-010119-t1x9gknd 7370 21 . . . cord-010119-t1x9gknd 7371 1 This this DT cord-010119-t1x9gknd 7371 2 may may MD cord-010119-t1x9gknd 7371 3 be be VB cord-010119-t1x9gknd 7371 4 due due JJ cord-010119-t1x9gknd 7371 5 to to IN cord-010119-t1x9gknd 7371 6 the the DT cord-010119-t1x9gknd 7371 7 washing washing NN cord-010119-t1x9gknd 7371 8 phase phase NN cord-010119-t1x9gknd 7371 9 in in IN cord-010119-t1x9gknd 7371 10 this this DT cord-010119-t1x9gknd 7371 11 technique technique NN cord-010119-t1x9gknd 7371 12 which which WDT cord-010119-t1x9gknd 7371 13 dissipates dissipate VBZ cord-010119-t1x9gknd 7371 14 rouleaux rouleaux JJ cord-010119-t1x9gknd 7371 15 formation formation NN cord-010119-t1x9gknd 7371 16 . . . cord-010119-t1x9gknd 7372 1 Reactivity reactivity NN cord-010119-t1x9gknd 7372 2 due due IN cord-010119-t1x9gknd 7372 3 to to IN cord-010119-t1x9gknd 7372 4 cold cold JJ cord-010119-t1x9gknd 7372 5 reactive reactive JJ cord-010119-t1x9gknd 7372 6 antibodies antibody NNS cord-010119-t1x9gknd 7372 7 can can MD cord-010119-t1x9gknd 7372 8 be be VB cord-010119-t1x9gknd 7372 9 eliminated eliminate VBN cord-010119-t1x9gknd 7372 10 by by IN cord-010119-t1x9gknd 7372 11 performance performance NN cord-010119-t1x9gknd 7372 12 at at IN cord-010119-t1x9gknd 7372 13 strict strict JJ cord-010119-t1x9gknd 7372 14 378C. 378c. CD cord-010119-t1x9gknd 7373 1 Our -PRON- PRP$ cord-010119-t1x9gknd 7373 2 practice practice NN cord-010119-t1x9gknd 7373 3 is be VBZ cord-010119-t1x9gknd 7373 4 now now RB cord-010119-t1x9gknd 7373 5 to to TO cord-010119-t1x9gknd 7373 6 use use VB cord-010119-t1x9gknd 7373 7 both both DT cord-010119-t1x9gknd 7373 8 DTT DTT NNP cord-010119-t1x9gknd 7373 9 IAT IAT NNP cord-010119-t1x9gknd 7373 10 methods method NNS cord-010119-t1x9gknd 7373 11 on on IN cord-010119-t1x9gknd 7373 12 initial initial JJ cord-010119-t1x9gknd 7373 13 patient patient NN cord-010119-t1x9gknd 7373 14 referral referral NN cord-010119-t1x9gknd 7373 15 , , , cord-010119-t1x9gknd 7373 16 if if IN cord-010119-t1x9gknd 7373 17 residual residual JJ cord-010119-t1x9gknd 7373 18 reactivity reactivity NN cord-010119-t1x9gknd 7373 19 in in IN cord-010119-t1x9gknd 7373 20 GC GC NNP cord-010119-t1x9gknd 7373 21 is be VBZ cord-010119-t1x9gknd 7373 22 observed observe VBN cord-010119-t1x9gknd 7373 23 use use NN cord-010119-t1x9gknd 7373 24 LISS LISS NNP cord-010119-t1x9gknd 7373 25 tube tube NN cord-010119-t1x9gknd 7373 26 in in IN cord-010119-t1x9gknd 7373 27 preference preference NN cord-010119-t1x9gknd 7373 28 thereafter thereafter RB cord-010119-t1x9gknd 7373 29 in in IN cord-010119-t1x9gknd 7373 30 these these DT cord-010119-t1x9gknd 7373 31 patients patient NNS cord-010119-t1x9gknd 7373 32 . . . cord-010119-t1x9gknd 7374 1 A a DT cord-010119-t1x9gknd 7374 2 further further JJ cord-010119-t1x9gknd 7374 3 observation observation NN cord-010119-t1x9gknd 7374 4 is be VBZ cord-010119-t1x9gknd 7374 5 that that DT cord-010119-t1x9gknd 7374 6 investigation investigation NN cord-010119-t1x9gknd 7374 7 of of IN cord-010119-t1x9gknd 7374 8 pan pan NN cord-010119-t1x9gknd 7374 9 - - NN cord-010119-t1x9gknd 7374 10 agglutination agglutination NN cord-010119-t1x9gknd 7374 11 could could MD cord-010119-t1x9gknd 7374 12 include include VB cord-010119-t1x9gknd 7374 13 the the DT cord-010119-t1x9gknd 7374 14 use use NN cord-010119-t1x9gknd 7374 15 of of IN cord-010119-t1x9gknd 7374 16 cord cord NN cord-010119-t1x9gknd 7374 17 cells cell NNS cord-010119-t1x9gknd 7374 18 to to TO cord-010119-t1x9gknd 7374 19 confirm confirm VB cord-010119-t1x9gknd 7374 20 / / SYM cord-010119-t1x9gknd 7374 21 exclude exclude VB cord-010119-t1x9gknd 7374 22 DARA DARA NNP cord-010119-t1x9gknd 7374 23 use use NN cord-010119-t1x9gknd 7374 24 if if IN cord-010119-t1x9gknd 7374 25 suspected suspect VBN cord-010119-t1x9gknd 7374 26 . . . cord-010119-t1x9gknd 7375 1 Wendy Wendy NNP cord-010119-t1x9gknd 7375 2 Beres Beres NNP cord-010119-t1x9gknd 7375 3 * * NFP cord-010119-t1x9gknd 7375 4 1 1 CD cord-010119-t1x9gknd 7375 5 , , , cord-010119-t1x9gknd 7375 6 Sandra Sandra NNP cord-010119-t1x9gknd 7375 7 Nance Nance NNP cord-010119-t1x9gknd 7375 8 2 2 CD cord-010119-t1x9gknd 7375 9 , , , cord-010119-t1x9gknd 7375 10 David David NNP cord-010119-t1x9gknd 7375 11 Moolten Moolten NNP cord-010119-t1x9gknd 7375 12 3 3 CD cord-010119-t1x9gknd 7375 13 and and CC cord-010119-t1x9gknd 7375 14 P. P. NNP cord-010119-t1x9gknd 7375 15 Dayand Dayand NNP cord-010119-t1x9gknd 7375 16 Borge Borge NNP cord-010119-t1x9gknd 7375 17 3 3 CD cord-010119-t1x9gknd 7375 18 . . . cord-010119-t1x9gknd 7376 1 ( ( -LRB- cord-010119-t1x9gknd 7376 2 2):47 2):47 CD cord-010119-t1x9gknd 7376 3 - - SYM cord-010119-t1x9gknd 7376 4 53 53 CD cord-010119-t1x9gknd 7376 5 ) ) -RRB- cord-010119-t1x9gknd 7376 6 . . . cord-010119-t1x9gknd 7377 1 Our -PRON- PRP$ cord-010119-t1x9gknd 7377 2 laboratory laboratory NN cord-010119-t1x9gknd 7377 3 tested test VBD cord-010119-t1x9gknd 7377 4 random random JJ cord-010119-t1x9gknd 7377 5 allogeneic allogeneic IN cord-010119-t1x9gknd 7377 6 blood blood NN cord-010119-t1x9gknd 7377 7 donors donor NNS cord-010119-t1x9gknd 7377 8 , , , cord-010119-t1x9gknd 7377 9 and and CC cord-010119-t1x9gknd 7377 10 autologous autologous JJ cord-010119-t1x9gknd 7377 11 donors donor NNS cord-010119-t1x9gknd 7377 12 ( ( -LRB- cord-010119-t1x9gknd 7377 13 which which WDT cord-010119-t1x9gknd 7377 14 were be VBD cord-010119-t1x9gknd 7377 15 intended intend VBN cord-010119-t1x9gknd 7377 16 to to TO cord-010119-t1x9gknd 7377 17 represent represent VB cord-010119-t1x9gknd 7377 18 a a DT cord-010119-t1x9gknd 7377 19 hospitalized hospitalize VBN cord-010119-t1x9gknd 7377 20 patient patient JJ cord-010119-t1x9gknd 7377 21 population population NN cord-010119-t1x9gknd 7377 22 ) ) -RRB- cord-010119-t1x9gknd 7377 23 , , , cord-010119-t1x9gknd 7377 24 to to TO cord-010119-t1x9gknd 7377 25 determine determine VB cord-010119-t1x9gknd 7377 26 a a DT cord-010119-t1x9gknd 7377 27 mean mean NN cord-010119-t1x9gknd 7377 28 and and CC cord-010119-t1x9gknd 7377 29 range range NN cord-010119-t1x9gknd 7377 30 of of IN cord-010119-t1x9gknd 7377 31 " " `` cord-010119-t1x9gknd 7377 32 normal normal JJ cord-010119-t1x9gknd 7377 33 " " '' cord-010119-t1x9gknd 7377 34 levels level NNS cord-010119-t1x9gknd 7377 35 . . . cord-010119-t1x9gknd 7378 1 This this DT cord-010119-t1x9gknd 7378 2 2.5 2.5 CD cord-010119-t1x9gknd 7378 3 year year NN cord-010119-t1x9gknd 7378 4 retrospective retrospective JJ cord-010119-t1x9gknd 7378 5 study study NN cord-010119-t1x9gknd 7378 6 was be VBD cord-010119-t1x9gknd 7378 7 performed perform VBN cord-010119-t1x9gknd 7378 8 to to TO cord-010119-t1x9gknd 7378 9 assess assess VB cord-010119-t1x9gknd 7378 10 levels level NNS cord-010119-t1x9gknd 7378 11 of of IN cord-010119-t1x9gknd 7378 12 RBC RBC NNP cord-010119-t1x9gknd 7378 13 - - HYPH cord-010119-t1x9gknd 7378 14 bound bind VBN cord-010119-t1x9gknd 7378 15 IgG IgG NNP cord-010119-t1x9gknd 7378 16 , , , cord-010119-t1x9gknd 7378 17 IgA IgA NNP cord-010119-t1x9gknd 7378 18 and and CC cord-010119-t1x9gknd 7378 19 IgM IgM NNP cord-010119-t1x9gknd 7378 20 in in IN cord-010119-t1x9gknd 7378 21 normal normal JJ cord-010119-t1x9gknd 7378 22 donors donor NNS cord-010119-t1x9gknd 7378 23 . . . cord-010119-t1x9gknd 7379 1 Study Study NNP cord-010119-t1x9gknd 7379 2 Design Design NNP cord-010119-t1x9gknd 7379 3 / / SYM cord-010119-t1x9gknd 7379 4 Method method NN cord-010119-t1x9gknd 7379 5 : : : cord-010119-t1x9gknd 7379 6 Residual Residual NNP cord-010119-t1x9gknd 7379 7 EDTA EDTA NNP cord-010119-t1x9gknd 7379 8 - - HYPH cord-010119-t1x9gknd 7379 9 anticoagulated anticoagulate VBN cord-010119-t1x9gknd 7379 10 aliquots aliquot NNS cord-010119-t1x9gknd 7379 11 from from IN cord-010119-t1x9gknd 7379 12 150 150 CD cord-010119-t1x9gknd 7379 13 random random JJ cord-010119-t1x9gknd 7379 14 allogeneic allogeneic NN cord-010119-t1x9gknd 7379 15 and and CC cord-010119-t1x9gknd 7379 16 20 20 CD cord-010119-t1x9gknd 7379 17 autologous autologous JJ cord-010119-t1x9gknd 7379 18 blood blood NN cord-010119-t1x9gknd 7379 19 donors donor NNS cord-010119-t1x9gknd 7379 20 were be VBD cord-010119-t1x9gknd 7379 21 sequestered sequester VBN cord-010119-t1x9gknd 7379 22 and and CC cord-010119-t1x9gknd 7379 23 tested test VBN cord-010119-t1x9gknd 7379 24 per per IN cord-010119-t1x9gknd 7379 25 Institutional Institutional NNP cord-010119-t1x9gknd 7379 26 Review Review NNP cord-010119-t1x9gknd 7379 27 Board Board NNP cord-010119-t1x9gknd 7379 28 approved approve VBD cord-010119-t1x9gknd 7379 29 protocol protocol NN cord-010119-t1x9gknd 7379 30 . . . cord-010119-t1x9gknd 7380 1 The the DT cord-010119-t1x9gknd 7380 2 samples sample NNS cord-010119-t1x9gknd 7380 3 were be VBD cord-010119-t1x9gknd 7380 4 tested test VBN cord-010119-t1x9gknd 7380 5 by by IN cord-010119-t1x9gknd 7380 6 FC FC NNP cord-010119-t1x9gknd 7380 7 with with IN cord-010119-t1x9gknd 7380 8 fluorescein fluorescein NN cord-010119-t1x9gknd 7380 9 isothiocyanate isothiocyanate NN cord-010119-t1x9gknd 7380 10 ( ( -LRB- cord-010119-t1x9gknd 7380 11 FITC)-labeled fitc)-labele VBN cord-010119-t1x9gknd 7380 12 anti anti JJ cord-010119-t1x9gknd 7380 13 - - JJ cord-010119-t1x9gknd 7380 14 human human JJ cord-010119-t1x9gknd 7380 15 IgG IgG NNP cord-010119-t1x9gknd 7380 16 and and CC cord-010119-t1x9gknd 7380 17 IgA IgA NNP cord-010119-t1x9gknd 7381 1 ( ( -LRB- cord-010119-t1x9gknd 7381 2 Jackson Jackson NNP cord-010119-t1x9gknd 7381 3 ImmunoResearch ImmunoResearch NNP cord-010119-t1x9gknd 7381 4 Lab Lab NNP cord-010119-t1x9gknd 7381 5 , , , cord-010119-t1x9gknd 7381 6 West West NNP cord-010119-t1x9gknd 7381 7 Grove Grove NNP cord-010119-t1x9gknd 7381 8 , , , cord-010119-t1x9gknd 7381 9 PA PA NNP cord-010119-t1x9gknd 7381 10 ) ) -RRB- cord-010119-t1x9gknd 7381 11 or or CC cord-010119-t1x9gknd 7381 12 FITC FITC NNP cord-010119-t1x9gknd 7381 13 - - HYPH cord-010119-t1x9gknd 7381 14 labeled label VBN cord-010119-t1x9gknd 7381 15 anti anti JJ cord-010119-t1x9gknd 7381 16 - - JJ cord-010119-t1x9gknd 7381 17 human human JJ cord-010119-t1x9gknd 7381 18 IgM IgM NNP cord-010119-t1x9gknd 7381 19 ( ( -LRB- cord-010119-t1x9gknd 7381 20 Life Life NNP cord-010119-t1x9gknd 7381 21 Technologies Technologies NNPS cord-010119-t1x9gknd 7381 22 , , , cord-010119-t1x9gknd 7381 23 Carlsbad Carlsbad NNP cord-010119-t1x9gknd 7381 24 , , , cord-010119-t1x9gknd 7381 25 CA CA NNP cord-010119-t1x9gknd 7381 26 ) ) -RRB- cord-010119-t1x9gknd 7381 27 at at IN cord-010119-t1x9gknd 7381 28 optimized optimize VBN cord-010119-t1x9gknd 7381 29 dilutions dilution NNS cord-010119-t1x9gknd 7381 30 in in IN cord-010119-t1x9gknd 7381 31 Dulbecco Dulbecco NNP cord-010119-t1x9gknd 7381 32 's 's POS cord-010119-t1x9gknd 7381 33 PBS PBS NNP cord-010119-t1x9gknd 7381 34 containing contain VBG cord-010119-t1x9gknd 7381 35 0.6 0.6 CD cord-010119-t1x9gknd 7381 36 % % NN cord-010119-t1x9gknd 7381 37 BSA BSA NNP cord-010119-t1x9gknd 7381 38 . . . cord-010119-t1x9gknd 7382 1 The the DT cord-010119-t1x9gknd 7382 2 Becton Becton NNP cord-010119-t1x9gknd 7382 3 Dickinson Dickinson NNP cord-010119-t1x9gknd 7382 4 FACSCalibur facscalibur NN cord-010119-t1x9gknd 7382 5 TM TM NNP cord-010119-t1x9gknd 7382 6 or or CC cord-010119-t1x9gknd 7382 7 FACScan facscan JJ cord-010119-t1x9gknd 7382 8 TM TM NNP cord-010119-t1x9gknd 7382 9 ( ( -LRB- cord-010119-t1x9gknd 7382 10 San San NNP cord-010119-t1x9gknd 7382 11 Jose Jose NNP cord-010119-t1x9gknd 7382 12 , , , cord-010119-t1x9gknd 7382 13 CA CA NNP cord-010119-t1x9gknd 7382 14 ) ) -RRB- cord-010119-t1x9gknd 7382 15 FC FC NNP cord-010119-t1x9gknd 7382 16 analyzed analyze VBD cord-010119-t1x9gknd 7382 17 50k 50k CD cord-010119-t1x9gknd 7382 18 RBCs rbc NNS cord-010119-t1x9gknd 7382 19 from from IN cord-010119-t1x9gknd 7382 20 each each DT cord-010119-t1x9gknd 7382 21 sample sample NN cord-010119-t1x9gknd 7382 22 . . . cord-010119-t1x9gknd 7383 1 EDTA EDTA NNP cord-010119-t1x9gknd 7383 2 - - HYPH cord-010119-t1x9gknd 7383 3 anticoagulated anticoagulate VBN cord-010119-t1x9gknd 7383 4 samples sample NNS cord-010119-t1x9gknd 7383 5 and and CC cord-010119-t1x9gknd 7383 6 Ig Ig NNP cord-010119-t1x9gknd 7383 7 coated coat VBD cord-010119-t1x9gknd 7383 8 control control NN cord-010119-t1x9gknd 7383 9 RBCs rbc NNS cord-010119-t1x9gknd 7383 10 were be VBD cord-010119-t1x9gknd 7383 11 tested test VBN cord-010119-t1x9gknd 7383 12 to to TO cord-010119-t1x9gknd 7383 13 determine determine VB cord-010119-t1x9gknd 7383 14 FC FC NNP cord-010119-t1x9gknd 7383 15 settings setting NNS cord-010119-t1x9gknd 7383 16 and and CC cord-010119-t1x9gknd 7383 17 control control NN cord-010119-t1x9gknd 7383 18 for for IN cord-010119-t1x9gknd 7383 19 validity validity NN cord-010119-t1x9gknd 7383 20 and and CC cord-010119-t1x9gknd 7383 21 cross cross NN cord-010119-t1x9gknd 7383 22 - - NN cord-010119-t1x9gknd 7383 23 reactivity reactivity NN cord-010119-t1x9gknd 7383 24 . . . cord-010119-t1x9gknd 7384 1 Controls control NNS cord-010119-t1x9gknd 7384 2 reacted react VBD cord-010119-t1x9gknd 7384 3 as as IN cord-010119-t1x9gknd 7384 4 expected expect VBN cord-010119-t1x9gknd 7384 5 . . . cord-010119-t1x9gknd 7385 1 There there EX cord-010119-t1x9gknd 7385 2 were be VBD cord-010119-t1x9gknd 7385 3 less less RBR cord-010119-t1x9gknd 7385 4 autologous autologous JJ cord-010119-t1x9gknd 7385 5 donors donor NNS cord-010119-t1x9gknd 7385 6 tested test VBN cord-010119-t1x9gknd 7385 7 and and CC cord-010119-t1x9gknd 7385 8 with with IN cord-010119-t1x9gknd 7385 9 a a DT cord-010119-t1x9gknd 7385 10 mean mean JJ cord-010119-t1x9gknd 7385 11 age age NN cord-010119-t1x9gknd 7385 12 of of IN cord-010119-t1x9gknd 7385 13 62 62 CD cord-010119-t1x9gknd 7385 14 these these DT cord-010119-t1x9gknd 7385 15 donors donor NNS cord-010119-t1x9gknd 7385 16 could could MD cord-010119-t1x9gknd 7385 17 have have VB cord-010119-t1x9gknd 7385 18 been be VBN cord-010119-t1x9gknd 7385 19 older old JJR cord-010119-t1x9gknd 7385 20 than than IN cord-010119-t1x9gknd 7385 21 the the DT cord-010119-t1x9gknd 7385 22 allogeneic allogeneic NN cord-010119-t1x9gknd 7385 23 donors donor NNS cord-010119-t1x9gknd 7385 24 , , , cord-010119-t1x9gknd 7385 25 but but CC cord-010119-t1x9gknd 7385 26 the the DT cord-010119-t1x9gknd 7385 27 mean mean JJ cord-010119-t1x9gknd 7385 28 age age NN cord-010119-t1x9gknd 7385 29 of of IN cord-010119-t1x9gknd 7385 30 the the DT cord-010119-t1x9gknd 7385 31 allogeneic allogeneic NN cord-010119-t1x9gknd 7385 32 donors donor NNS cord-010119-t1x9gknd 7385 33 was be VBD cord-010119-t1x9gknd 7385 34 not not RB cord-010119-t1x9gknd 7385 35 captured capture VBN cord-010119-t1x9gknd 7385 36 . . . cord-010119-t1x9gknd 7386 1 Despite despite IN cord-010119-t1x9gknd 7386 2 the the DT cord-010119-t1x9gknd 7386 3 relatively relatively RB cord-010119-t1x9gknd 7386 4 small small JJ cord-010119-t1x9gknd 7386 5 number number NN cord-010119-t1x9gknd 7386 6 of of IN cord-010119-t1x9gknd 7386 7 samples sample NNS cord-010119-t1x9gknd 7386 8 tested test VBN cord-010119-t1x9gknd 7386 9 there there EX cord-010119-t1x9gknd 7386 10 was be VBD cord-010119-t1x9gknd 7386 11 a a DT cord-010119-t1x9gknd 7386 12 higher high JJR cord-010119-t1x9gknd 7386 13 than than IN cord-010119-t1x9gknd 7386 14 expected expect VBN cord-010119-t1x9gknd 7386 15 instance instance NN cord-010119-t1x9gknd 7386 16 of of IN cord-010119-t1x9gknd 7386 17 allogeneic allogeneic NN cord-010119-t1x9gknd 7386 18 donors donor NNS cord-010119-t1x9gknd 7386 19 having have VBG cord-010119-t1x9gknd 7386 20 elevated elevate VBN cord-010119-t1x9gknd 7386 21 RBC RBC NNP cord-010119-t1x9gknd 7386 22 - - HYPH cord-010119-t1x9gknd 7386 23 bound bind VBN cord-010119-t1x9gknd 7386 24 IgA IgA NNP cord-010119-t1x9gknd 7386 25 , , , cord-010119-t1x9gknd 7386 26 IgG IgG NNP cord-010119-t1x9gknd 7386 27 , , , cord-010119-t1x9gknd 7386 28 and and CC cord-010119-t1x9gknd 7386 29 IgM IgM NNP cord-010119-t1x9gknd 7386 30 levels level NNS cord-010119-t1x9gknd 7386 31 . . . cord-010119-t1x9gknd 7387 1 This this DT cord-010119-t1x9gknd 7387 2 emphasizes emphasize VBZ cord-010119-t1x9gknd 7387 3 the the DT cord-010119-t1x9gknd 7387 4 need need NN cord-010119-t1x9gknd 7387 5 to to TO cord-010119-t1x9gknd 7387 6 include include VB cord-010119-t1x9gknd 7387 7 testing testing NN cord-010119-t1x9gknd 7387 8 of of IN cord-010119-t1x9gknd 7387 9 normal normal JJ cord-010119-t1x9gknd 7387 10 donor donor NN cord-010119-t1x9gknd 7387 11 populations population NNS cord-010119-t1x9gknd 7387 12 in in IN cord-010119-t1x9gknd 7387 13 establishing establish VBG cord-010119-t1x9gknd 7387 14 expected expect VBN cord-010119-t1x9gknd 7387 15 reactivity reactivity NN cord-010119-t1x9gknd 7387 16 , , , cord-010119-t1x9gknd 7387 17 thus thus RB cord-010119-t1x9gknd 7387 18 normal normal JJ cord-010119-t1x9gknd 7387 19 and and CC cord-010119-t1x9gknd 7387 20 abnormal abnormal JJ cord-010119-t1x9gknd 7387 21 ranges range NNS cord-010119-t1x9gknd 7387 22 for for IN cord-010119-t1x9gknd 7387 23 flow flow NN cord-010119-t1x9gknd 7387 24 cytometric cytometric NN cord-010119-t1x9gknd 7387 25 testing testing NN cord-010119-t1x9gknd 7387 26 . . . cord-010119-t1x9gknd 7388 1 Long long RB cord-010119-t1x9gknd 7388 2 Range Range NNP cord-010119-t1x9gknd 7388 3 PCR PCR NNP cord-010119-t1x9gknd 7388 4 Reveals reveal VBZ cord-010119-t1x9gknd 7388 5 the the DT cord-010119-t1x9gknd 7388 6 Genetic Genetic NNP cord-010119-t1x9gknd 7388 7 Basis Basis NNP cord-010119-t1x9gknd 7388 8 of of IN cord-010119-t1x9gknd 7388 9 an an DT cord-010119-t1x9gknd 7388 10 Antibody Antibody NNP cord-010119-t1x9gknd 7388 11 in in IN cord-010119-t1x9gknd 7388 12 Pregnancy Pregnancy NNP cord-010119-t1x9gknd 7388 13 to to IN cord-010119-t1x9gknd 7388 14 a a DT cord-010119-t1x9gknd 7388 15 High High NNP cord-010119-t1x9gknd 7388 16 Prevalence prevalence NN cord-010119-t1x9gknd 7388 17 MNS MNS NNP cord-010119-t1x9gknd 7388 18 Antigen Antigen NNP cord-010119-t1x9gknd 7388 19 Judith Judith NNP cord-010119-t1x9gknd 7388 20 Aeschlimann Aeschlimann NNP cord-010119-t1x9gknd 7388 21 * * NFP cord-010119-t1x9gknd 7388 22 1 1 CD cord-010119-t1x9gknd 7388 23 , , , cord-010119-t1x9gknd 7388 24 Anna Anna NNP cord-010119-t1x9gknd 7388 25 Burgos Burgos NNP cord-010119-t1x9gknd 7388 26 1 1 CD cord-010119-t1x9gknd 7388 27 , , , cord-010119-t1x9gknd 7388 28 Virginia Virginia NNP cord-010119-t1x9gknd 7388 29 Lew Lew NNP cord-010119-t1x9gknd 7388 30 2 2 CD cord-010119-t1x9gknd 7388 31 , , , cord-010119-t1x9gknd 7388 32 Sunitha Sunitha NNP cord-010119-t1x9gknd 7388 33 Vege Vege NNP cord-010119-t1x9gknd 7388 34 1 1 CD cord-010119-t1x9gknd 7388 35 , , , cord-010119-t1x9gknd 7388 36 Susan Susan NNP cord-010119-t1x9gknd 7388 37 Veneman Veneman NNP cord-010119-t1x9gknd 7388 38 3 3 CD cord-010119-t1x9gknd 7388 39 , , , cord-010119-t1x9gknd 7388 40 Christopher Christopher NNP cord-010119-t1x9gknd 7388 41 J J NNP cord-010119-t1x9gknd 7388 42 Gresens Gresens NNP cord-010119-t1x9gknd 7388 43 3 3 CD cord-010119-t1x9gknd 7388 44 , , , cord-010119-t1x9gknd 7388 45 Jonathan Jonathan NNP cord-010119-t1x9gknd 7388 46 Hughes Hughes NNP cord-010119-t1x9gknd 7388 47 3 3 CD cord-010119-t1x9gknd 7388 48 and and CC cord-010119-t1x9gknd 7388 49 Connie Connie NNP cord-010119-t1x9gknd 7388 50 M. M. NNP cord-010119-t1x9gknd 7388 51 Westhoff Westhoff NNP cord-010119-t1x9gknd 7388 52 1 1 CD cord-010119-t1x9gknd 7388 53 . . . cord-010119-t1x9gknd 7389 1 1 1 LS cord-010119-t1x9gknd 7390 1 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 7390 2 and and CC cord-010119-t1x9gknd 7390 3 Genomics Genomics NNPS cord-010119-t1x9gknd 7390 4 Laboratory Laboratory NNP cord-010119-t1x9gknd 7390 5 , , , cord-010119-t1x9gknd 7390 6 New New NNP cord-010119-t1x9gknd 7390 7 York York NNP cord-010119-t1x9gknd 7390 8 Blood Blood NNP cord-010119-t1x9gknd 7390 9 Center Center NNP cord-010119-t1x9gknd 7390 10 , , , cord-010119-t1x9gknd 7390 11 2 2 CD cord-010119-t1x9gknd 7390 12 Blood blood NN cord-010119-t1x9gknd 7390 13 Centers Centers NNPS cord-010119-t1x9gknd 7390 14 of of IN cord-010119-t1x9gknd 7390 15 the the DT cord-010119-t1x9gknd 7390 16 Pacific Pacific NNP cord-010119-t1x9gknd 7390 17 , , , cord-010119-t1x9gknd 7390 18 3 3 CD cord-010119-t1x9gknd 7390 19 BloodSource BloodSource NNP cord-010119-t1x9gknd 7390 20 Background Background NNP cord-010119-t1x9gknd 7390 21 / / SYM cord-010119-t1x9gknd 7390 22 Case Case NNP cord-010119-t1x9gknd 7390 23 Studies Studies NNPS cord-010119-t1x9gknd 7390 24 : : : cord-010119-t1x9gknd 7391 1 Recombination recombination NN cord-010119-t1x9gknd 7391 2 events event NNS cord-010119-t1x9gknd 7391 3 have have VBP cord-010119-t1x9gknd 7391 4 generated generate VBN cord-010119-t1x9gknd 7391 5 many many JJ cord-010119-t1x9gknd 7391 6 GYPA GYPA NNP cord-010119-t1x9gknd 7391 7 and and CC cord-010119-t1x9gknd 7391 8 GYPB gypb NN cord-010119-t1x9gknd 7391 9 hybrids hybrid NNS cord-010119-t1x9gknd 7391 10 giving give VBG cord-010119-t1x9gknd 7391 11 rise rise NN cord-010119-t1x9gknd 7391 12 to to IN cord-010119-t1x9gknd 7391 13 glycophorin glycophorin NNP cord-010119-t1x9gknd 7391 14 ( ( -LRB- cord-010119-t1x9gknd 7391 15 GP gp NN cord-010119-t1x9gknd 7391 16 ) ) -RRB- cord-010119-t1x9gknd 7391 17 variants variant NNS cord-010119-t1x9gknd 7391 18 that that WDT cord-010119-t1x9gknd 7391 19 express express VBP cord-010119-t1x9gknd 7391 20 low low JJ cord-010119-t1x9gknd 7391 21 - - HYPH cord-010119-t1x9gknd 7391 22 prevalence prevalence NN cord-010119-t1x9gknd 7391 23 antigens antigen NNS cord-010119-t1x9gknd 7391 24 ( ( -LRB- cord-010119-t1x9gknd 7391 25 e.g. e.g. RB cord-010119-t1x9gknd 7391 26 Mia Mia NNP cord-010119-t1x9gknd 7391 27 , , , cord-010119-t1x9gknd 7391 28 MINY MINY NNP cord-010119-t1x9gknd 7391 29 , , , cord-010119-t1x9gknd 7391 30 Mur Mur NNP cord-010119-t1x9gknd 7391 31 ) ) -RRB- cord-010119-t1x9gknd 7391 32 . . . cord-010119-t1x9gknd 7392 1 In in IN cord-010119-t1x9gknd 7392 2 rare rare JJ cord-010119-t1x9gknd 7392 3 individuals individual NNS cord-010119-t1x9gknd 7392 4 who who WP cord-010119-t1x9gknd 7392 5 are be VBP cord-010119-t1x9gknd 7392 6 homozygous homozygous JJ cord-010119-t1x9gknd 7392 7 these these DT cord-010119-t1x9gknd 7392 8 alleles allele NNS cord-010119-t1x9gknd 7392 9 are be VBP cord-010119-t1x9gknd 7392 10 associated associate VBN cord-010119-t1x9gknd 7392 11 with with IN cord-010119-t1x9gknd 7392 12 lack lack NN cord-010119-t1x9gknd 7392 13 of of IN cord-010119-t1x9gknd 7392 14 highprevalence highprevalence NN cord-010119-t1x9gknd 7392 15 antigens antigen NNS cord-010119-t1x9gknd 7392 16 ( ( -LRB- cord-010119-t1x9gknd 7392 17 e.g. e.g. RB cord-010119-t1x9gknd 7392 18 ENKT ENKT NNP cord-010119-t1x9gknd 7392 19 , , , cord-010119-t1x9gknd 7392 20 ENEH ENEH NNP cord-010119-t1x9gknd 7392 21 , , , cord-010119-t1x9gknd 7392 22 ENAV ENAV NNP cord-010119-t1x9gknd 7392 23 ) ) -RRB- cord-010119-t1x9gknd 7392 24 . . . cord-010119-t1x9gknd 7393 1 Complex complex JJ cord-010119-t1x9gknd 7393 2 hybrid hybrid NN cord-010119-t1x9gknd 7393 3 recombination recombination NN cord-010119-t1x9gknd 7393 4 events event NNS cord-010119-t1x9gknd 7393 5 can can MD cord-010119-t1x9gknd 7393 6 make make VB cord-010119-t1x9gknd 7393 7 it -PRON- PRP cord-010119-t1x9gknd 7393 8 challenging challenging JJ cord-010119-t1x9gknd 7393 9 to to TO cord-010119-t1x9gknd 7393 10 elucidate elucidate VB cord-010119-t1x9gknd 7393 11 specific specific JJ cord-010119-t1x9gknd 7393 12 alleles allele NNS cord-010119-t1x9gknd 7393 13 present present JJ cord-010119-t1x9gknd 7393 14 in in IN cord-010119-t1x9gknd 7393 15 samples sample NNS cord-010119-t1x9gknd 7393 16 , , , cord-010119-t1x9gknd 7393 17 particularly particularly RB cord-010119-t1x9gknd 7393 18 heterozygotes heterozygote NNS cord-010119-t1x9gknd 7393 19 . . . cord-010119-t1x9gknd 7394 1 We -PRON- PRP cord-010119-t1x9gknd 7394 2 investigated investigate VBD cord-010119-t1x9gknd 7394 3 samples sample NNS cord-010119-t1x9gknd 7394 4 from from IN cord-010119-t1x9gknd 7394 5 a a DT cord-010119-t1x9gknd 7394 6 pregnant pregnant JJ cord-010119-t1x9gknd 7394 7 Asian asian JJ cord-010119-t1x9gknd 7394 8 ( ( -LRB- cord-010119-t1x9gknd 7394 9 Hmong Hmong NNP cord-010119-t1x9gknd 7394 10 ) ) -RRB- cord-010119-t1x9gknd 7394 11 woman woman NN cord-010119-t1x9gknd 7394 12 with with IN cord-010119-t1x9gknd 7394 13 an an DT cord-010119-t1x9gknd 7394 14 antibody antibody NN cord-010119-t1x9gknd 7394 15 to to IN cord-010119-t1x9gknd 7394 16 an an DT cord-010119-t1x9gknd 7394 17 unidentified unidentified JJ cord-010119-t1x9gknd 7394 18 highprevalence highprevalence NN cord-010119-t1x9gknd 7394 19 MNS MNS NNP cord-010119-t1x9gknd 7394 20 antigen antigen NN cord-010119-t1x9gknd 7394 21 , , , cord-010119-t1x9gknd 7394 22 and and CC cord-010119-t1x9gknd 7394 23 samples sample NNS cord-010119-t1x9gknd 7394 24 from from IN cord-010119-t1x9gknd 7394 25 her -PRON- PRP$ cord-010119-t1x9gknd 7394 26 sister sister NN cord-010119-t1x9gknd 7394 27 . . . cord-010119-t1x9gknd 7395 1 Study Study NNP cord-010119-t1x9gknd 7395 2 Design Design NNP cord-010119-t1x9gknd 7395 3 / / SYM cord-010119-t1x9gknd 7395 4 Method method NN cord-010119-t1x9gknd 7395 5 : : : cord-010119-t1x9gknd 7396 1 Standard standard JJ cord-010119-t1x9gknd 7396 2 methods method NNS cord-010119-t1x9gknd 7396 3 were be VBD cord-010119-t1x9gknd 7396 4 used use VBN cord-010119-t1x9gknd 7396 5 for for IN cord-010119-t1x9gknd 7396 6 RBC RBC NNP cord-010119-t1x9gknd 7396 7 typing type VBG cord-010119-t1x9gknd 7396 8 with with IN cord-010119-t1x9gknd 7396 9 licensed licensed JJ cord-010119-t1x9gknd 7396 10 and and CC cord-010119-t1x9gknd 7396 11 unlicensed unlicensed JJ cord-010119-t1x9gknd 7396 12 reagents reagent NNS cord-010119-t1x9gknd 7396 13 and and CC cord-010119-t1x9gknd 7396 14 for for IN cord-010119-t1x9gknd 7396 15 antibody antibody NN cord-010119-t1x9gknd 7396 16 identification identification NN cord-010119-t1x9gknd 7396 17 . . . cord-010119-t1x9gknd 7397 1 DNA DNA NNP cord-010119-t1x9gknd 7397 2 was be VBD cord-010119-t1x9gknd 7397 3 isolated isolate VBN cord-010119-t1x9gknd 7397 4 from from IN cord-010119-t1x9gknd 7397 5 WBCs wbc NNS cord-010119-t1x9gknd 7397 6 , , , cord-010119-t1x9gknd 7397 7 and and CC cord-010119-t1x9gknd 7397 8 HEA HEA NNP cord-010119-t1x9gknd 7397 9 PreciseType PreciseType NNP cord-010119-t1x9gknd 7397 10 , , , cord-010119-t1x9gknd 7397 11 exon exon NN cord-010119-t1x9gknd 7397 12 - - HYPH cord-010119-t1x9gknd 7397 13 specific specific JJ cord-010119-t1x9gknd 7397 14 amplification amplification NN cord-010119-t1x9gknd 7397 15 and and CC cord-010119-t1x9gknd 7397 16 sequencing sequence VBG cord-010119-t1x9gknd 7397 17 GYPB GYPB NNP cord-010119-t1x9gknd 7397 18 exons exon NNS cord-010119-t1x9gknd 7397 19 1 1 CD cord-010119-t1x9gknd 7397 20 - - SYM cord-010119-t1x9gknd 7397 21 6 6 CD cord-010119-t1x9gknd 7397 22 , , , cord-010119-t1x9gknd 7397 23 and and CC cord-010119-t1x9gknd 7397 24 long long JJ cord-010119-t1x9gknd 7397 25 range range NN cord-010119-t1x9gknd 7397 26 sequencing sequencing NN cord-010119-t1x9gknd 7397 27 of of IN cord-010119-t1x9gknd 7397 28 exon exon NN cord-010119-t1x9gknd 7397 29 2 2 CD cord-010119-t1x9gknd 7397 30 - - SYM cord-010119-t1x9gknd 7397 31 6 6 CD cord-010119-t1x9gknd 7397 32 ( ( -LRB- cord-010119-t1x9gknd 7397 33 5.4 5.4 CD cord-010119-t1x9gknd 7397 34 kb kb NNP cord-010119-t1x9gknd 7397 35 amplicon amplicon NNP cord-010119-t1x9gknd 7397 36 ) ) -RRB- cord-010119-t1x9gknd 7397 37 were be VBD cord-010119-t1x9gknd 7397 38 performed perform VBN cord-010119-t1x9gknd 7397 39 . . . cord-010119-t1x9gknd 7398 1 SNP SNP NNP cord-010119-t1x9gknd 7398 2 - - HYPH cord-010119-t1x9gknd 7398 3 specific specific JJ cord-010119-t1x9gknd 7398 4 primers primer NNS cord-010119-t1x9gknd 7398 5 were be VBD cord-010119-t1x9gknd 7398 6 used use VBN cord-010119-t1x9gknd 7398 7 to to TO cord-010119-t1x9gknd 7398 8 associate associate VB cord-010119-t1x9gknd 7398 9 changes change NNS cord-010119-t1x9gknd 7398 10 ( ( -LRB- cord-010119-t1x9gknd 7398 11 phasing phase VBG cord-010119-t1x9gknd 7398 12 ) ) -RRB- cord-010119-t1x9gknd 7398 13 to to IN cord-010119-t1x9gknd 7398 14 specific specific JJ cord-010119-t1x9gknd 7398 15 alleles allele NNS cord-010119-t1x9gknd 7398 16 . . . cord-010119-t1x9gknd 7399 1 Results/ Results/ . cord-010119-t1x9gknd 7400 1 Finding finding NN cord-010119-t1x9gknd 7400 2 : : : cord-010119-t1x9gknd 7401 1 RBCs rbc NNS cord-010119-t1x9gknd 7401 2 of of IN cord-010119-t1x9gknd 7401 3 the the DT cord-010119-t1x9gknd 7401 4 pregnant pregnant JJ cord-010119-t1x9gknd 7401 5 proband proband NN cord-010119-t1x9gknd 7401 6 typed type VBN cord-010119-t1x9gknd 7402 1 S S NNP cord-010119-t1x9gknd 7402 2 - - HYPH cord-010119-t1x9gknd 7402 3 s-(Gammaclone s-(Gammaclone VBN cord-010119-t1x9gknd 7402 4 anti anti NNP cord-010119-t1x9gknd 7402 5 - - NNP cord-010119-t1x9gknd 7402 6 s s NNP cord-010119-t1x9gknd 7402 7 ) ) -RRB- cord-010119-t1x9gknd 7402 8 , , , cord-010119-t1x9gknd 7402 9 and and CC cord-010119-t1x9gknd 7402 10 the the DT cord-010119-t1x9gknd 7402 11 plasma plasma NN cord-010119-t1x9gknd 7402 12 reactivity reactivity NN cord-010119-t1x9gknd 7402 13 was be VBD cord-010119-t1x9gknd 7402 14 consistent consistent JJ cord-010119-t1x9gknd 7402 15 with with IN cord-010119-t1x9gknd 7402 16 an an DT cord-010119-t1x9gknd 7402 17 antibody antibody NN cord-010119-t1x9gknd 7402 18 to to IN cord-010119-t1x9gknd 7402 19 a a DT cord-010119-t1x9gknd 7402 20 high high JJ cord-010119-t1x9gknd 7402 21 Background Background NNP cord-010119-t1x9gknd 7402 22 / / SYM cord-010119-t1x9gknd 7402 23 Case Case NNP cord-010119-t1x9gknd 7402 24 Studies Studies NNPS cord-010119-t1x9gknd 7402 25 : : : cord-010119-t1x9gknd 7402 26 The the DT cord-010119-t1x9gknd 7402 27 RhD rhd NN cord-010119-t1x9gknd 7402 28 antigen antigen NN cord-010119-t1x9gknd 7402 29 is be VBZ cord-010119-t1x9gknd 7403 1 clinically clinically RB cord-010119-t1x9gknd 7403 2 significant significant JJ cord-010119-t1x9gknd 7403 3 and and CC cord-010119-t1x9gknd 7403 4 immunogenic immunogenic JJ cord-010119-t1x9gknd 7403 5 and and CC cord-010119-t1x9gknd 7403 6 therefore therefore RB cord-010119-t1x9gknd 7403 7 individuals individual NNS cord-010119-t1x9gknd 7403 8 who who WP cord-010119-t1x9gknd 7403 9 develop develop VBP cord-010119-t1x9gknd 7403 10 anti anti JJ cord-010119-t1x9gknd 7403 11 - - JJ cord-010119-t1x9gknd 7403 12 D d JJ cord-010119-t1x9gknd 7403 13 are be VBP cord-010119-t1x9gknd 7403 14 at at IN cord-010119-t1x9gknd 7403 15 risk risk NN cord-010119-t1x9gknd 7403 16 of of IN cord-010119-t1x9gknd 7403 17 haemolytic haemolytic JJ cord-010119-t1x9gknd 7403 18 transfusion transfusion NN cord-010119-t1x9gknd 7403 19 reaction reaction NN cord-010119-t1x9gknd 7403 20 . . . cord-010119-t1x9gknd 7404 1 RHD RHD NNP cord-010119-t1x9gknd 7404 2 polymorphism polymorphism NN cord-010119-t1x9gknd 7404 3 shows show VBZ cord-010119-t1x9gknd 7404 4 substantial substantial JJ cord-010119-t1x9gknd 7404 5 ethnic ethnic JJ cord-010119-t1x9gknd 7404 6 variability variability NN cord-010119-t1x9gknd 7404 7 and and CC cord-010119-t1x9gknd 7404 8 at at IN cord-010119-t1x9gknd 7404 9 least least JJS cord-010119-t1x9gknd 7404 10 100 100 CD cord-010119-t1x9gknd 7404 11 RHD RHD NNP cord-010119-t1x9gknd 7404 12 variants variant NNS cord-010119-t1x9gknd 7404 13 associated associate VBN cord-010119-t1x9gknd 7404 14 with with IN cord-010119-t1x9gknd 7404 15 weak weak JJ cord-010119-t1x9gknd 7404 16 D d NN cord-010119-t1x9gknd 7404 17 alleles allele NNS cord-010119-t1x9gknd 7404 18 have have VBP cord-010119-t1x9gknd 7404 19 been be VBN cord-010119-t1x9gknd 7404 20 reported report VBN cord-010119-t1x9gknd 7404 21 . . . cord-010119-t1x9gknd 7405 1 In in IN cord-010119-t1x9gknd 7405 2 this this DT cord-010119-t1x9gknd 7405 3 study study NN cord-010119-t1x9gknd 7405 4 , , , cord-010119-t1x9gknd 7405 5 we -PRON- PRP cord-010119-t1x9gknd 7405 6 report report VBP cord-010119-t1x9gknd 7405 7 two two CD cord-010119-t1x9gknd 7405 8 new new JJ cord-010119-t1x9gknd 7405 9 RHD RHD NNP cord-010119-t1x9gknd 7405 10 alleles allele NNS cord-010119-t1x9gknd 7405 11 in in IN cord-010119-t1x9gknd 7405 12 Brazilian brazilian JJ cord-010119-t1x9gknd 7405 13 blood blood NN cord-010119-t1x9gknd 7405 14 donors donor NNS cord-010119-t1x9gknd 7405 15 associated associate VBN cord-010119-t1x9gknd 7405 16 with with IN cord-010119-t1x9gknd 7405 17 weak weak JJ cord-010119-t1x9gknd 7405 18 D D NNP cord-010119-t1x9gknd 7405 19 antigen antigen NN cord-010119-t1x9gknd 7405 20 expression expression NN cord-010119-t1x9gknd 7405 21 . . . cord-010119-t1x9gknd 7406 1 Study Study NNP cord-010119-t1x9gknd 7406 2 Design Design NNP cord-010119-t1x9gknd 7406 3 / / SYM cord-010119-t1x9gknd 7406 4 Method method NN cord-010119-t1x9gknd 7406 5 : : : cord-010119-t1x9gknd 7406 6 The the DT cord-010119-t1x9gknd 7406 7 D d NN cord-010119-t1x9gknd 7406 8 status status NN cord-010119-t1x9gknd 7406 9 was be VBD cord-010119-t1x9gknd 7406 10 evaluated evaluate VBN cord-010119-t1x9gknd 7406 11 with with IN cord-010119-t1x9gknd 7406 12 4 4 CD cord-010119-t1x9gknd 7406 13 commercially commercially RB cord-010119-t1x9gknd 7406 14 available available JJ cord-010119-t1x9gknd 7406 15 monoclonal monoclonal JJ cord-010119-t1x9gknd 7406 16 anti anti JJ cord-010119-t1x9gknd 7406 17 - - JJ cord-010119-t1x9gknd 7406 18 D d JJ cord-010119-t1x9gknd 7406 19 reagents reagent NNS cord-010119-t1x9gknd 7406 20 : : : cord-010119-t1x9gknd 7406 21 1 1 CD cord-010119-t1x9gknd 7406 22 blended blended NNP cord-010119-t1x9gknd 7406 23 IgM IgM NNP cord-010119-t1x9gknd 7406 24 / / SYM cord-010119-t1x9gknd 7406 25 IgG IgG NNP cord-010119-t1x9gknd 7406 26 ( ( -LRB- cord-010119-t1x9gknd 7406 27 clones clone NNS cord-010119-t1x9gknd 7406 28 TH-28/ th-28/ IN cord-010119-t1x9gknd 7406 29 MS-26 MS-26 NNP cord-010119-t1x9gknd 7406 30 ) ) -RRB- cord-010119-t1x9gknd 7406 31 , , , cord-010119-t1x9gknd 7406 32 2 2 CD cord-010119-t1x9gknd 7406 33 IgM IgM NNP cord-010119-t1x9gknd 7406 34 ( ( -LRB- cord-010119-t1x9gknd 7406 35 clones clone NNS cord-010119-t1x9gknd 7406 36 MS201 MS201 NNP cord-010119-t1x9gknd 7406 37 and and CC cord-010119-t1x9gknd 7406 38 P3x61 P3x61 NNP cord-010119-t1x9gknd 7406 39 ) ) -RRB- cord-010119-t1x9gknd 7406 40 and and CC cord-010119-t1x9gknd 7406 41 1 1 CD cord-010119-t1x9gknd 7406 42 IgG IgG NNP cord-010119-t1x9gknd 7406 43 ( ( -LRB- cord-010119-t1x9gknd 7406 44 MS26 MS26 NNP cord-010119-t1x9gknd 7406 45 ) ) -RRB- cord-010119-t1x9gknd 7406 46 in in IN cord-010119-t1x9gknd 7406 47 tube tube NN cord-010119-t1x9gknd 7406 48 and and CC cord-010119-t1x9gknd 7406 49 on on IN cord-010119-t1x9gknd 7406 50 gel gel NN cord-010119-t1x9gknd 7406 51 cards card NNS cord-010119-t1x9gknd 7406 52 . . . cord-010119-t1x9gknd 7407 1 C C NNP cord-010119-t1x9gknd 7407 2 , , , cord-010119-t1x9gknd 7407 3 c c NNP cord-010119-t1x9gknd 7407 4 , , , cord-010119-t1x9gknd 7407 5 E E NNP cord-010119-t1x9gknd 7407 6 and and CC cord-010119-t1x9gknd 7407 7 e e NN cord-010119-t1x9gknd 7407 8 phenotyping phenotyping NN cord-010119-t1x9gknd 7407 9 were be VBD cord-010119-t1x9gknd 7407 10 performed perform VBN cord-010119-t1x9gknd 7407 11 in in IN cord-010119-t1x9gknd 7407 12 gel gel NN cord-010119-t1x9gknd 7407 13 . . . cord-010119-t1x9gknd 7408 1 Most most RBS cord-010119-t1x9gknd 7408 2 common common JJ cord-010119-t1x9gknd 7408 3 weak weak JJ cord-010119-t1x9gknd 7408 4 D d NN cord-010119-t1x9gknd 7408 5 and and CC cord-010119-t1x9gknd 7408 6 partial partial JJ cord-010119-t1x9gknd 7408 7 D d NN cord-010119-t1x9gknd 7408 8 alleles allele NNS cord-010119-t1x9gknd 7408 9 were be VBD cord-010119-t1x9gknd 7408 10 investigated investigate VBN cord-010119-t1x9gknd 7408 11 by by IN cord-010119-t1x9gknd 7408 12 allele allele NN cord-010119-t1x9gknd 7408 13 specific specific JJ cord-010119-t1x9gknd 7408 14 ( ( -LRB- cord-010119-t1x9gknd 7408 15 AS AS NNP cord-010119-t1x9gknd 7408 16 ) ) -RRB- cord-010119-t1x9gknd 7408 17 PCR PCR NNP cord-010119-t1x9gknd 7408 18 and and CC cord-010119-t1x9gknd 7408 19 with with IN cord-010119-t1x9gknd 7408 20 the the DT cord-010119-t1x9gknd 7408 21 RHD RHD NNP cord-010119-t1x9gknd 7408 22 BeadChip BeadChip NNP cord-010119-t1x9gknd 7408 23 platform platform NN cord-010119-t1x9gknd 7408 24 from from IN cord-010119-t1x9gknd 7408 25 Immucor Immucor NNP cord-010119-t1x9gknd 7408 26 . . . cord-010119-t1x9gknd 7409 1 Direct direct JJ cord-010119-t1x9gknd 7409 2 automated automate VBN cord-010119-t1x9gknd 7409 3 sequencing sequencing NN cord-010119-t1x9gknd 7409 4 of of IN cord-010119-t1x9gknd 7409 5 the the DT cord-010119-t1x9gknd 7409 6 10 10 CD cord-010119-t1x9gknd 7409 7 RHD RHD NNP cord-010119-t1x9gknd 7409 8 exons exon NNS cord-010119-t1x9gknd 7409 9 and and CC cord-010119-t1x9gknd 7409 10 flanking flanking JJ cord-010119-t1x9gknd 7409 11 intron intron NN cord-010119-t1x9gknd 7409 12 regions region NNS cord-010119-t1x9gknd 7409 13 was be VBD cord-010119-t1x9gknd 7409 14 performed perform VBN cord-010119-t1x9gknd 7409 15 by by IN cord-010119-t1x9gknd 7409 16 the the DT cord-010119-t1x9gknd 7409 17 Sanger Sanger NNP cord-010119-t1x9gknd 7409 18 dideoxy dideoxy NN cord-010119-t1x9gknd 7409 19 method method NN cord-010119-t1x9gknd 7409 20 . . . cord-010119-t1x9gknd 7410 1 In in IN cord-010119-t1x9gknd 7410 2 order order NN cord-010119-t1x9gknd 7410 3 to to TO cord-010119-t1x9gknd 7410 4 determine determine VB cord-010119-t1x9gknd 7410 5 RHD RHD NNP cord-010119-t1x9gknd 7410 6 allelic allelic JJ cord-010119-t1x9gknd 7410 7 combinations combination NNS cord-010119-t1x9gknd 7410 8 , , , cord-010119-t1x9gknd 7410 9 we -PRON- PRP cord-010119-t1x9gknd 7410 10 also also RB cord-010119-t1x9gknd 7410 11 performed perform VBD cord-010119-t1x9gknd 7410 12 Rh Rh NNP cord-010119-t1x9gknd 7410 13 - - HYPH cord-010119-t1x9gknd 7410 14 cDNA cdna NN cord-010119-t1x9gknd 7410 15 cloning cloning NN cord-010119-t1x9gknd 7410 16 and and CC cord-010119-t1x9gknd 7410 17 sequencing sequencing NN cord-010119-t1x9gknd 7410 18 . . . cord-010119-t1x9gknd 7411 1 Background Background NNP cord-010119-t1x9gknd 7411 2 / / SYM cord-010119-t1x9gknd 7411 3 Case Case NNP cord-010119-t1x9gknd 7411 4 Studies Studies NNPS cord-010119-t1x9gknd 7411 5 : : : cord-010119-t1x9gknd 7411 6 Donors donor NNS cord-010119-t1x9gknd 7411 7 negative negative JJ cord-010119-t1x9gknd 7411 8 for for IN cord-010119-t1x9gknd 7411 9 multiple multiple JJ cord-010119-t1x9gknd 7411 10 common common JJ cord-010119-t1x9gknd 7411 11 antigens antigen NNS cord-010119-t1x9gknd 7411 12 or or CC cord-010119-t1x9gknd 7411 13 lacking lack VBG cord-010119-t1x9gknd 7411 14 a a DT cord-010119-t1x9gknd 7411 15 high high JJ cord-010119-t1x9gknd 7411 16 prevalence prevalence NN cord-010119-t1x9gknd 7411 17 antigen antigen NN cord-010119-t1x9gknd 7411 18 are be VBP cord-010119-t1x9gknd 7411 19 efficiently efficiently RB cord-010119-t1x9gknd 7411 20 identified identify VBN cord-010119-t1x9gknd 7411 21 using use VBG cord-010119-t1x9gknd 7411 22 a a DT cord-010119-t1x9gknd 7411 23 red red JJ cord-010119-t1x9gknd 7411 24 blood blood NN cord-010119-t1x9gknd 7411 25 cell cell NN cord-010119-t1x9gknd 7411 26 ( ( -LRB- cord-010119-t1x9gknd 7411 27 RBC RBC NNP cord-010119-t1x9gknd 7411 28 ) ) -RRB- cord-010119-t1x9gknd 7411 29 genotyping genotyping NN cord-010119-t1x9gknd 7411 30 panel panel NN cord-010119-t1x9gknd 7411 31 . . . cord-010119-t1x9gknd 7412 1 When when WRB cord-010119-t1x9gknd 7412 2 serology serology NN cord-010119-t1x9gknd 7412 3 is be VBZ cord-010119-t1x9gknd 7412 4 used use VBN cord-010119-t1x9gknd 7412 5 to to TO cord-010119-t1x9gknd 7412 6 confirm confirm VB cord-010119-t1x9gknd 7412 7 antigen antigen NN cord-010119-t1x9gknd 7412 8 negative negative JJ cord-010119-t1x9gknd 7412 9 status status NN cord-010119-t1x9gknd 7412 10 , , , cord-010119-t1x9gknd 7412 11 discrepancies discrepancy NNS cord-010119-t1x9gknd 7412 12 are be VBP cord-010119-t1x9gknd 7412 13 identified identify VBN cord-010119-t1x9gknd 7412 14 , , , cord-010119-t1x9gknd 7412 15 albeit albeit RB cord-010119-t1x9gknd 7412 16 rarely rarely RB cord-010119-t1x9gknd 7412 17 . . . cord-010119-t1x9gknd 7413 1 Investigation investigation NN cord-010119-t1x9gknd 7413 2 of of IN cord-010119-t1x9gknd 7413 3 the the DT cord-010119-t1x9gknd 7413 4 discrepancy discrepancy NN cord-010119-t1x9gknd 7413 5 often often RB cord-010119-t1x9gknd 7413 6 leads lead VBZ cord-010119-t1x9gknd 7413 7 to to IN cord-010119-t1x9gknd 7413 8 identification identification NN cord-010119-t1x9gknd 7413 9 of of IN cord-010119-t1x9gknd 7413 10 variant variant JJ cord-010119-t1x9gknd 7413 11 antigens antigen NNS cord-010119-t1x9gknd 7413 12 . . . cord-010119-t1x9gknd 7414 1 It -PRON- PRP cord-010119-t1x9gknd 7414 2 is be VBZ cord-010119-t1x9gknd 7414 3 known know VBN cord-010119-t1x9gknd 7414 4 that that IN cord-010119-t1x9gknd 7414 5 the the DT cord-010119-t1x9gknd 7414 6 set set NN cord-010119-t1x9gknd 7414 7 of of IN cord-010119-t1x9gknd 7414 8 GYP GYP NNP cord-010119-t1x9gknd 7414 9 variants variant NNS cord-010119-t1x9gknd 7414 10 associated associate VBN cord-010119-t1x9gknd 7414 11 with with IN cord-010119-t1x9gknd 7414 12 expression expression NN cord-010119-t1x9gknd 7414 13 of of IN cord-010119-t1x9gknd 7414 14 the the DT cord-010119-t1x9gknd 7414 15 St St NNP cord-010119-t1x9gknd 7414 16 a a DT cord-010119-t1x9gknd 7414 17 antigen antigen NN cord-010119-t1x9gknd 7414 18 can can MD cord-010119-t1x9gknd 7414 19 also also RB cord-010119-t1x9gknd 7414 20 be be VB cord-010119-t1x9gknd 7414 21 associated associate VBN cord-010119-t1x9gknd 7414 22 with with IN cord-010119-t1x9gknd 7414 23 N n CD cord-010119-t1x9gknd 7414 24 typing typing NN cord-010119-t1x9gknd 7414 25 discrepancies discrepancy NNS cord-010119-t1x9gknd 7414 26 in in IN cord-010119-t1x9gknd 7414 27 M1N M1N NNS cord-010119-t1x9gknd 7414 28 - - HYPH cord-010119-t1x9gknd 7414 29 individuals individual NNS cord-010119-t1x9gknd 7414 30 ( ( -LRB- cord-010119-t1x9gknd 7414 31 Meyer Meyer NNP cord-010119-t1x9gknd 7414 32 et et NNP cord-010119-t1x9gknd 7414 33 al al NNP cord-010119-t1x9gknd 7414 34 . . . cord-010119-t1x9gknd 7415 1 Br Br NNP cord-010119-t1x9gknd 7415 2 J J NNP cord-010119-t1x9gknd 7415 3 Haematol Haematol NNP cord-010119-t1x9gknd 7415 4 . . . cord-010119-t1x9gknd 7416 1 2016 2016 CD cord-010119-t1x9gknd 7416 2 ; ; : cord-010119-t1x9gknd 7416 3 174:624 174:624 CD cord-010119-t1x9gknd 7416 4 - - SYM cord-010119-t1x9gknd 7416 5 36 36 CD cord-010119-t1x9gknd 7416 6 ) ) -RRB- cord-010119-t1x9gknd 7416 7 . . . cord-010119-t1x9gknd 7417 1 The the DT cord-010119-t1x9gknd 7417 2 St St NNP cord-010119-t1x9gknd 7417 3 a a DT cord-010119-t1x9gknd 7417 4 allele allele NN cord-010119-t1x9gknd 7417 5 , , , cord-010119-t1x9gknd 7417 6 also also RB cord-010119-t1x9gknd 7417 7 described describe VBN cord-010119-t1x9gknd 7417 8 as as IN cord-010119-t1x9gknd 7417 9 GYP*401 GYP*401 NNP cord-010119-t1x9gknd 7417 10 , , , cord-010119-t1x9gknd 7417 11 is be VBZ cord-010119-t1x9gknd 7417 12 a a DT cord-010119-t1x9gknd 7417 13 hybrid hybrid JJ cord-010119-t1x9gknd 7417 14 GYPB GYPB NNP cord-010119-t1x9gknd 7417 15 - - HYPH cord-010119-t1x9gknd 7417 16 GYPAtranscript gypatranscript NN cord-010119-t1x9gknd 7417 17 with with IN cord-010119-t1x9gknd 7417 18 the the DT cord-010119-t1x9gknd 7417 19 crossover crossover NN cord-010119-t1x9gknd 7417 20 in in IN cord-010119-t1x9gknd 7417 21 intron intron NN cord-010119-t1x9gknd 7417 22 3 3 CD cord-010119-t1x9gknd 7417 23 . . . cord-010119-t1x9gknd 7418 1 We -PRON- PRP cord-010119-t1x9gknd 7418 2 sought seek VBD cord-010119-t1x9gknd 7418 3 to to TO cord-010119-t1x9gknd 7418 4 investigate investigate VB cord-010119-t1x9gknd 7418 5 five five CD cord-010119-t1x9gknd 7418 6 N n NN cord-010119-t1x9gknd 7418 7 typing typing NN cord-010119-t1x9gknd 7418 8 discrepancies discrepancy NNS cord-010119-t1x9gknd 7418 9 for for IN cord-010119-t1x9gknd 7418 10 which which WDT cord-010119-t1x9gknd 7418 11 alternative alternative JJ cord-010119-t1x9gknd 7418 12 genotyping genotyping NN cord-010119-t1x9gknd 7418 13 methodology methodology NN cord-010119-t1x9gknd 7418 14 was be VBD cord-010119-t1x9gknd 7418 15 performed perform VBN cord-010119-t1x9gknd 7418 16 and and CC cord-010119-t1x9gknd 7418 17 found find VBN cord-010119-t1x9gknd 7418 18 to to TO cord-010119-t1x9gknd 7418 19 be be VB cord-010119-t1x9gknd 7418 20 concordant concordant JJ cord-010119-t1x9gknd 7418 21 with with IN cord-010119-t1x9gknd 7418 22 the the DT cord-010119-t1x9gknd 7418 23 initial initial JJ cord-010119-t1x9gknd 7418 24 panel panel NN cord-010119-t1x9gknd 7418 25 . . . cord-010119-t1x9gknd 7419 1 Background Background NNP cord-010119-t1x9gknd 7419 2 / / SYM cord-010119-t1x9gknd 7419 3 Case Case NNP cord-010119-t1x9gknd 7419 4 Studies Studies NNPS cord-010119-t1x9gknd 7419 5 : : : cord-010119-t1x9gknd 7420 1 A a DT cord-010119-t1x9gknd 7420 2 sample sample NN cord-010119-t1x9gknd 7420 3 from from IN cord-010119-t1x9gknd 7420 4 a a DT cord-010119-t1x9gknd 7420 5 24 24 CD cord-010119-t1x9gknd 7420 6 years year NNS cord-010119-t1x9gknd 7420 7 old old JJ cord-010119-t1x9gknd 7420 8 pregnant pregnant JJ cord-010119-t1x9gknd 7420 9 , , , cord-010119-t1x9gknd 7420 10 African african JJ cord-010119-t1x9gknd 7420 11 American american JJ cord-010119-t1x9gknd 7420 12 female female NN cord-010119-t1x9gknd 7420 13 G1P0 G1P0 NNP cord-010119-t1x9gknd 7420 14 was be VBD cord-010119-t1x9gknd 7420 15 sent send VBN cord-010119-t1x9gknd 7420 16 to to IN cord-010119-t1x9gknd 7420 17 the the DT cord-010119-t1x9gknd 7420 18 blood blood NN cord-010119-t1x9gknd 7420 19 bank bank NN cord-010119-t1x9gknd 7420 20 for for IN cord-010119-t1x9gknd 7420 21 ABO ABO NNP cord-010119-t1x9gknd 7420 22 / / SYM cord-010119-t1x9gknd 7420 23 Rh Rh NNP cord-010119-t1x9gknd 7420 24 and and CC cord-010119-t1x9gknd 7420 25 antibody antibody NN cord-010119-t1x9gknd 7420 26 screen screen NN cord-010119-t1x9gknd 7420 27 . . . cord-010119-t1x9gknd 7421 1 The the DT cord-010119-t1x9gknd 7421 2 sample sample NN cord-010119-t1x9gknd 7421 3 was be VBD cord-010119-t1x9gknd 7421 4 analyzed analyze VBN cord-010119-t1x9gknd 7421 5 using use VBG cord-010119-t1x9gknd 7421 6 the the DT cord-010119-t1x9gknd 7421 7 Provue Provue NNP cord-010119-t1x9gknd 7421 8 analyzer analyzer NN cord-010119-t1x9gknd 7421 9 ( ( -LRB- cord-010119-t1x9gknd 7421 10 Ortho Ortho NNP cord-010119-t1x9gknd 7421 11 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 7421 12 ) ) -RRB- cord-010119-t1x9gknd 7421 13 . . . cord-010119-t1x9gknd 7422 1 The the DT cord-010119-t1x9gknd 7422 2 patient patient NN cord-010119-t1x9gknd 7422 3 was be VBD cord-010119-t1x9gknd 7422 4 typed type VBN cord-010119-t1x9gknd 7422 5 as as IN cord-010119-t1x9gknd 7422 6 O o NN cord-010119-t1x9gknd 7422 7 pos pos NN cord-010119-t1x9gknd 7422 8 with with IN cord-010119-t1x9gknd 7422 9 no no DT cord-010119-t1x9gknd 7422 10 reverse reverse JJ cord-010119-t1x9gknd 7422 11 type type NN cord-010119-t1x9gknd 7422 12 discrepancy discrepancy NN cord-010119-t1x9gknd 7422 13 . . . cord-010119-t1x9gknd 7423 1 A a DT cord-010119-t1x9gknd 7423 2 retype retype NN cord-010119-t1x9gknd 7423 3 of of IN cord-010119-t1x9gknd 7423 4 the the DT cord-010119-t1x9gknd 7423 5 same same JJ cord-010119-t1x9gknd 7423 6 sample sample NN cord-010119-t1x9gknd 7423 7 was be VBD cord-010119-t1x9gknd 7423 8 performed perform VBN cord-010119-t1x9gknd 7423 9 using use VBG cord-010119-t1x9gknd 7423 10 tube tube NN cord-010119-t1x9gknd 7423 11 method method NN cord-010119-t1x9gknd 7423 12 with with IN cord-010119-t1x9gknd 7423 13 Biorad Biorad NNP cord-010119-t1x9gknd 7423 14 reagents reagent NNS cord-010119-t1x9gknd 7423 15 per per IN cord-010119-t1x9gknd 7423 16 Hospital hospital NN cord-010119-t1x9gknd 7423 17 policy policy NN cord-010119-t1x9gknd 7423 18 due due JJ cord-010119-t1x9gknd 7423 19 to to IN cord-010119-t1x9gknd 7423 20 no no DT cord-010119-t1x9gknd 7423 21 previous previous JJ cord-010119-t1x9gknd 7423 22 ABO ABO NNP cord-010119-t1x9gknd 7423 23 / / SYM cord-010119-t1x9gknd 7423 24 Rh Rh NNP cord-010119-t1x9gknd 7423 25 history history NN cord-010119-t1x9gknd 7423 26 on on IN cord-010119-t1x9gknd 7423 27 file file NN cord-010119-t1x9gknd 7423 28 . . . cord-010119-t1x9gknd 7424 1 The the DT cord-010119-t1x9gknd 7424 2 retype retype NN cord-010119-t1x9gknd 7424 3 showed show VBD cord-010119-t1x9gknd 7424 4 that that IN cord-010119-t1x9gknd 7424 5 the the DT cord-010119-t1x9gknd 7424 6 patient patient NN cord-010119-t1x9gknd 7424 7 was be VBD cord-010119-t1x9gknd 7424 8 A a DT cord-010119-t1x9gknd 7424 9 subgroup subgroup NN cord-010119-t1x9gknd 7424 10 with with IN cord-010119-t1x9gknd 7424 11 Anti Anti NNP cord-010119-t1x9gknd 7424 12 - - NNP cord-010119-t1x9gknd 7424 13 A A NNP cord-010119-t1x9gknd 7424 14 1 1 CD cord-010119-t1x9gknd 7424 15 antibody antibody NN cord-010119-t1x9gknd 7424 16 present present JJ cord-010119-t1x9gknd 7424 17 in in IN cord-010119-t1x9gknd 7424 18 the the DT cord-010119-t1x9gknd 7424 19 plasma plasma NN cord-010119-t1x9gknd 7424 20 . . . cord-010119-t1x9gknd 7425 1 The the DT cord-010119-t1x9gknd 7425 2 sample sample NN cord-010119-t1x9gknd 7425 3 was be VBD cord-010119-t1x9gknd 7425 4 referred refer VBN cord-010119-t1x9gknd 7425 5 for for IN cord-010119-t1x9gknd 7425 6 genotyping genotyping NN cord-010119-t1x9gknd 7425 7 , , , cord-010119-t1x9gknd 7425 8 with with IN cord-010119-t1x9gknd 7425 9 the the DT cord-010119-t1x9gknd 7425 10 suspicion suspicion NN cord-010119-t1x9gknd 7425 11 of of IN cord-010119-t1x9gknd 7425 12 A a DT cord-010119-t1x9gknd 7425 13 3 3 CD cord-010119-t1x9gknd 7425 14 like like IN cord-010119-t1x9gknd 7425 15 phenotype phenotype NN cord-010119-t1x9gknd 7425 16 . . . cord-010119-t1x9gknd 7426 1 Genetic genetic JJ cord-010119-t1x9gknd 7426 2 testing testing NN cord-010119-t1x9gknd 7426 3 did do VBD cord-010119-t1x9gknd 7426 4 not not RB cord-010119-t1x9gknd 7426 5 support support VB cord-010119-t1x9gknd 7426 6 the the DT cord-010119-t1x9gknd 7426 7 serological serological JJ cord-010119-t1x9gknd 7426 8 findings finding NNS cord-010119-t1x9gknd 7426 9 of of IN cord-010119-t1x9gknd 7426 10 A a DT cord-010119-t1x9gknd 7426 11 3 3 CD cord-010119-t1x9gknd 7426 12 subgroup subgroup NN cord-010119-t1x9gknd 7426 13 and and CC cord-010119-t1x9gknd 7426 14 a a DT cord-010119-t1x9gknd 7426 15 new new JJ cord-010119-t1x9gknd 7426 16 ABO ABO NNP cord-010119-t1x9gknd 7426 17 allele allele NN cord-010119-t1x9gknd 7426 18 , , , cord-010119-t1x9gknd 7426 19 ABO*784C abo*784c NN cord-010119-t1x9gknd 7426 20 that that WDT cord-010119-t1x9gknd 7426 21 has have VBZ cord-010119-t1x9gknd 7426 22 never never RB cord-010119-t1x9gknd 7426 23 been be VBN cord-010119-t1x9gknd 7426 24 reported report VBN cord-010119-t1x9gknd 7426 25 in in IN cord-010119-t1x9gknd 7426 26 correlation correlation NN cord-010119-t1x9gknd 7426 27 with with IN cord-010119-t1x9gknd 7426 28 an an DT cord-010119-t1x9gknd 7426 29 A A NNP cord-010119-t1x9gknd 7426 30 3 3 CD cord-010119-t1x9gknd 7426 31 like like UH cord-010119-t1x9gknd 7426 32 subgroup subgroup NN cord-010119-t1x9gknd 7427 1 was be VBD cord-010119-t1x9gknd 7427 2 detected detect VBN cord-010119-t1x9gknd 7428 1 Study Study NNP cord-010119-t1x9gknd 7428 2 Design Design NNP cord-010119-t1x9gknd 7428 3 / / SYM cord-010119-t1x9gknd 7428 4 Method method NN cord-010119-t1x9gknd 7428 5 : : : cord-010119-t1x9gknd 7429 1 The the DT cord-010119-t1x9gknd 7429 2 patient patient NN cord-010119-t1x9gknd 7429 3 RBCs rbc NNS cord-010119-t1x9gknd 7429 4 were be VBD cord-010119-t1x9gknd 7429 5 typed type VBN cord-010119-t1x9gknd 7429 6 with with IN cord-010119-t1x9gknd 7429 7 anti anti JJ cord-010119-t1x9gknd 7429 8 - - JJ cord-010119-t1x9gknd 7429 9 A a NN cord-010119-t1x9gknd 7429 10 1 1 CD cord-010119-t1x9gknd 7429 11 ( ( -LRB- cord-010119-t1x9gknd 7429 12 Immucor Immucor NNP cord-010119-t1x9gknd 7429 13 ) ) -RRB- cord-010119-t1x9gknd 7429 14 and and CC cord-010119-t1x9gknd 7429 15 anti anti JJ cord-010119-t1x9gknd 7429 16 - - JJ cord-010119-t1x9gknd 7429 17 A a NN cord-010119-t1x9gknd 7429 18 , , , cord-010119-t1x9gknd 7429 19 B B NNP cord-010119-t1x9gknd 7429 20 ( ( -LRB- cord-010119-t1x9gknd 7429 21 Biorad Biorad NNP cord-010119-t1x9gknd 7429 22 and and CC cord-010119-t1x9gknd 7429 23 Grifols Grifols NNP cord-010119-t1x9gknd 7429 24 DG DG NNP cord-010119-t1x9gknd 7429 25 Gel Gel NNP cord-010119-t1x9gknd 7429 26 ) ) -RRB- cord-010119-t1x9gknd 7429 27 . . . cord-010119-t1x9gknd 7430 1 An an DT cord-010119-t1x9gknd 7430 2 Anti Anti NNP cord-010119-t1x9gknd 7430 3 - - JJ cord-010119-t1x9gknd 7430 4 A a DT cord-010119-t1x9gknd 7430 5 1 1 CD cord-010119-t1x9gknd 7430 6 antibody antibody NN cord-010119-t1x9gknd 7430 7 work work NN cord-010119-t1x9gknd 7430 8 up up RP cord-010119-t1x9gknd 7430 9 was be VBD cord-010119-t1x9gknd 7430 10 performed perform VBN cord-010119-t1x9gknd 7430 11 using use VBG cord-010119-t1x9gknd 7430 12 three three CD cord-010119-t1x9gknd 7430 13 different different JJ cord-010119-t1x9gknd 7430 14 lots lot NNS cord-010119-t1x9gknd 7430 15 of of IN cord-010119-t1x9gknd 7430 16 A a DT cord-010119-t1x9gknd 7430 17 1 1 CD cord-010119-t1x9gknd 7430 18 cells cell NNS cord-010119-t1x9gknd 7430 19 and and CC cord-010119-t1x9gknd 7430 20 three three CD cord-010119-t1x9gknd 7430 21 lots lot NNS cord-010119-t1x9gknd 7430 22 of of IN cord-010119-t1x9gknd 7430 23 A a DT cord-010119-t1x9gknd 7430 24 2 2 CD cord-010119-t1x9gknd 7430 25 cells cell NNS cord-010119-t1x9gknd 7430 26 , , , cord-010119-t1x9gknd 7430 27 as as RB cord-010119-t1x9gknd 7430 28 well well RB cord-010119-t1x9gknd 7430 29 as as IN cord-010119-t1x9gknd 7430 30 a a DT cord-010119-t1x9gknd 7430 31 type type NN cord-010119-t1x9gknd 7430 32 O o NN cord-010119-t1x9gknd 7430 33 screening screening NN cord-010119-t1x9gknd 7430 34 cell cell NN cord-010119-t1x9gknd 7430 35 and and CC cord-010119-t1x9gknd 7430 36 auto auto NN cord-010119-t1x9gknd 7430 37 control control NN cord-010119-t1x9gknd 7430 38 . . . cord-010119-t1x9gknd 7431 1 The the DT cord-010119-t1x9gknd 7431 2 tubes tube NNS cord-010119-t1x9gknd 7431 3 were be VBD cord-010119-t1x9gknd 7431 4 read read VBN cord-010119-t1x9gknd 7431 5 at at IN cord-010119-t1x9gknd 7431 6 IS is NN cord-010119-t1x9gknd 7431 7 and and CC cord-010119-t1x9gknd 7431 8 also also RB cord-010119-t1x9gknd 7431 9 incubated incubate VBN cord-010119-t1x9gknd 7431 10 at at IN cord-010119-t1x9gknd 7431 11 RT RT NNP cord-010119-t1x9gknd 7431 12 and and CC cord-010119-t1x9gknd 7431 13 48C 48c CD cord-010119-t1x9gknd 7431 14 for for IN cord-010119-t1x9gknd 7431 15 30min 30min NN cord-010119-t1x9gknd 7431 16 . . . cord-010119-t1x9gknd 7432 1 The the DT cord-010119-t1x9gknd 7432 2 patient patient NN cord-010119-t1x9gknd 7432 3 's 's POS cord-010119-t1x9gknd 7432 4 initial initial JJ cord-010119-t1x9gknd 7432 5 antibody antibody NN cord-010119-t1x9gknd 7432 6 screen screen NN cord-010119-t1x9gknd 7432 7 using use VBG cord-010119-t1x9gknd 7432 8 Ortho Ortho NNP cord-010119-t1x9gknd 7432 9 gel gel NN cord-010119-t1x9gknd 7432 10 was be VBD cord-010119-t1x9gknd 7432 11 negative negative JJ cord-010119-t1x9gknd 7432 12 . . . cord-010119-t1x9gknd 7433 1 Conclusion conclusion NN cord-010119-t1x9gknd 7433 2 : : : cord-010119-t1x9gknd 7434 1 The the DT cord-010119-t1x9gknd 7434 2 patient patient NN cord-010119-t1x9gknd 7434 3 delivered deliver VBD cord-010119-t1x9gknd 7434 4 a a DT cord-010119-t1x9gknd 7434 5 healthy healthy JJ cord-010119-t1x9gknd 7434 6 baby baby NN cord-010119-t1x9gknd 7434 7 boy boy NN cord-010119-t1x9gknd 7434 8 at at IN cord-010119-t1x9gknd 7434 9 35 35 CD cord-010119-t1x9gknd 7434 10 weeks week NNS cord-010119-t1x9gknd 7434 11 of of IN cord-010119-t1x9gknd 7434 12 gestation gestation NN cord-010119-t1x9gknd 7434 13 . . . cord-010119-t1x9gknd 7435 1 The the DT cord-010119-t1x9gknd 7435 2 baby baby NN cord-010119-t1x9gknd 7435 3 cord cord NN cord-010119-t1x9gknd 7435 4 was be VBD cord-010119-t1x9gknd 7435 5 sent send VBN cord-010119-t1x9gknd 7435 6 to to IN cord-010119-t1x9gknd 7435 7 the the DT cord-010119-t1x9gknd 7435 8 laboratory laboratory NN cord-010119-t1x9gknd 7435 9 . . . cord-010119-t1x9gknd 7436 1 The the DT cord-010119-t1x9gknd 7436 2 baby baby NN cord-010119-t1x9gknd 7436 3 serological serological JJ cord-010119-t1x9gknd 7436 4 type type NN cord-010119-t1x9gknd 7436 5 showed show VBD cord-010119-t1x9gknd 7436 6 an an DT cord-010119-t1x9gknd 7436 7 A a NN cord-010119-t1x9gknd 7436 8 3 3 CD cord-010119-t1x9gknd 7436 9 B b NN cord-010119-t1x9gknd 7436 10 phenotype phenotype NN cord-010119-t1x9gknd 7436 11 and and CC cord-010119-t1x9gknd 7436 12 it -PRON- PRP cord-010119-t1x9gknd 7436 13 was be VBD cord-010119-t1x9gknd 7436 14 referred refer VBN cord-010119-t1x9gknd 7436 15 for for IN cord-010119-t1x9gknd 7436 16 genetic genetic JJ cord-010119-t1x9gknd 7436 17 testing testing NN cord-010119-t1x9gknd 7436 18 . . . cord-010119-t1x9gknd 7437 1 The the DT cord-010119-t1x9gknd 7437 2 baby baby NN cord-010119-t1x9gknd 7437 3 RBCs rbc NNS cord-010119-t1x9gknd 7437 4 showed show VBD cord-010119-t1x9gknd 7437 5 the the DT cord-010119-t1x9gknd 7437 6 same same JJ cord-010119-t1x9gknd 7437 7 ABO*784C abo*784c NN cord-010119-t1x9gknd 7437 8 found find VBD cord-010119-t1x9gknd 7437 9 in in IN cord-010119-t1x9gknd 7437 10 the the DT cord-010119-t1x9gknd 7437 11 mother mother NN cord-010119-t1x9gknd 7437 12 . . . cord-010119-t1x9gknd 7438 1 The the DT cord-010119-t1x9gknd 7438 2 previously previously RB cord-010119-t1x9gknd 7438 3 reported report VBN cord-010119-t1x9gknd 7438 4 ABO*784A abo*784a NN cord-010119-t1x9gknd 7438 5 allele allele NN cord-010119-t1x9gknd 7438 6 encoded encode VBD cord-010119-t1x9gknd 7438 7 an an DT cord-010119-t1x9gknd 7438 8 Aspartic aspartic JJ cord-010119-t1x9gknd 7438 9 Acid acid NN cord-010119-t1x9gknd 7438 10 to to IN cord-010119-t1x9gknd 7438 11 Asparagine asparagine NN cord-010119-t1x9gknd 7438 12 change change NN cord-010119-t1x9gknd 7438 13 at at IN cord-010119-t1x9gknd 7438 14 position position NN cord-010119-t1x9gknd 7438 15 p.256 p.256 NNP cord-010119-t1x9gknd 7438 16 consistent consistent JJ cord-010119-t1x9gknd 7438 17 with with IN cord-010119-t1x9gknd 7438 18 an an DT cord-010119-t1x9gknd 7438 19 A a DT cord-010119-t1x9gknd 7438 20 weak weak JJ cord-010119-t1x9gknd 7438 21 phenotype phenotype NN cord-010119-t1x9gknd 7438 22 . . . cord-010119-t1x9gknd 7439 1 Also also RB cord-010119-t1x9gknd 7439 2 , , , cord-010119-t1x9gknd 7439 3 at at RB cord-010119-t1x9gknd 7439 4 least least RBS cord-010119-t1x9gknd 7439 5 five five CD cord-010119-t1x9gknd 7439 6 other other JJ cord-010119-t1x9gknd 7439 7 alleles allele NNS cord-010119-t1x9gknd 7439 8 encoding encode VBG cord-010119-t1x9gknd 7439 9 an an DT cord-010119-t1x9gknd 7439 10 A A NNP cord-010119-t1x9gknd 7439 11 3 3 CD cord-010119-t1x9gknd 7439 12 phenoytpe phenoytpe NNS cord-010119-t1x9gknd 7439 13 consisted consist VBN cord-010119-t1x9gknd 7439 14 of of IN cord-010119-t1x9gknd 7439 15 polymorphisms polymorphism NNS cord-010119-t1x9gknd 7439 16 at at IN cord-010119-t1x9gknd 7439 17 positions position NNS cord-010119-t1x9gknd 7439 18 c.745 c.745 RB cord-010119-t1x9gknd 7439 19 through through IN cord-010119-t1x9gknd 7439 20 c.871 c.871 NNP cord-010119-t1x9gknd 7439 21 , , , cord-010119-t1x9gknd 7439 22 giving give VBG cord-010119-t1x9gknd 7439 23 special special JJ cord-010119-t1x9gknd 7439 24 characteristics characteristic NNS cord-010119-t1x9gknd 7439 25 to to IN cord-010119-t1x9gknd 7439 26 this this DT cord-010119-t1x9gknd 7439 27 new new JJ cord-010119-t1x9gknd 7439 28 and and CC cord-010119-t1x9gknd 7439 29 unreported unreported JJ cord-010119-t1x9gknd 7439 30 ABO ABO NNP cord-010119-t1x9gknd 7439 31 allele allele NN cord-010119-t1x9gknd 7439 32 . . . cord-010119-t1x9gknd 7440 1 From from IN cord-010119-t1x9gknd 7440 2 the the DT cord-010119-t1x9gknd 7440 3 data datum NNS cord-010119-t1x9gknd 7440 4 collected collect VBN cord-010119-t1x9gknd 7440 5 , , , cord-010119-t1x9gknd 7440 6 it -PRON- PRP cord-010119-t1x9gknd 7440 7 can can MD cord-010119-t1x9gknd 7440 8 be be VB cord-010119-t1x9gknd 7440 9 concluded conclude VBN cord-010119-t1x9gknd 7440 10 that that IN cord-010119-t1x9gknd 7440 11 this this DT cord-010119-t1x9gknd 7440 12 A3/ A3/ NNP cord-010119-t1x9gknd 7440 13 Aweak Aweak NNP cord-010119-t1x9gknd 7440 14 phenotype phenotype NN cord-010119-t1x9gknd 7440 15 is be VBZ cord-010119-t1x9gknd 7440 16 encoded encode VBN cord-010119-t1x9gknd 7440 17 by by IN cord-010119-t1x9gknd 7440 18 the the DT cord-010119-t1x9gknd 7440 19 variant variant JJ cord-010119-t1x9gknd 7440 20 allele allele NN cord-010119-t1x9gknd 7441 1 ABO*784C. ABO*784C. NNP cord-010119-t1x9gknd 7442 1 This this DT cord-010119-t1x9gknd 7442 2 highlights highlight VBZ cord-010119-t1x9gknd 7442 3 the the DT cord-010119-t1x9gknd 7442 4 clinical clinical JJ cord-010119-t1x9gknd 7442 5 relevance relevance NN cord-010119-t1x9gknd 7442 6 of of IN cord-010119-t1x9gknd 7442 7 confirming confirm VBG cord-010119-t1x9gknd 7442 8 the the DT cord-010119-t1x9gknd 7442 9 serology serology NN cord-010119-t1x9gknd 7442 10 of of IN cord-010119-t1x9gknd 7442 11 ABO ABO NNP cord-010119-t1x9gknd 7442 12 subgroups subgroup NNS cord-010119-t1x9gknd 7442 13 by by IN cord-010119-t1x9gknd 7442 14 molecular molecular JJ cord-010119-t1x9gknd 7442 15 methods method NNS cord-010119-t1x9gknd 7442 16 . . . cord-010119-t1x9gknd 7443 1 Philip Philip NNP cord-010119-t1x9gknd 7443 2 Berardi Berardi NNP cord-010119-t1x9gknd 7443 3 * * NFP cord-010119-t1x9gknd 7443 4 , , , cord-010119-t1x9gknd 7443 5 Jacqueline Jacqueline NNP cord-010119-t1x9gknd 7443 6 Cote Cote NNP cord-010119-t1x9gknd 7443 7 , , , cord-010119-t1x9gknd 7443 8 Gwen Gwen NNP cord-010119-t1x9gknd 7443 9 Clarke Clarke NNP cord-010119-t1x9gknd 7443 10 , , , cord-010119-t1x9gknd 7443 11 Vito Vito NNP cord-010119-t1x9gknd 7443 12 Scalia Scalia NNP cord-010119-t1x9gknd 7443 13 , , , cord-010119-t1x9gknd 7443 14 Robert Robert NNP cord-010119-t1x9gknd 7443 15 Liwski Liwski NNP cord-010119-t1x9gknd 7443 16 and and CC cord-010119-t1x9gknd 7443 17 Mindy Mindy NNP cord-010119-t1x9gknd 7443 18 Goldman Goldman NNP cord-010119-t1x9gknd 7443 19 . . . cord-010119-t1x9gknd 7444 1 Canadian Canadian NNP cord-010119-t1x9gknd 7444 2 Blood Blood NNP cord-010119-t1x9gknd 7444 3 Services Services NNPS cord-010119-t1x9gknd 7444 4 Background Background NNP cord-010119-t1x9gknd 7444 5 / / SYM cord-010119-t1x9gknd 7444 6 Case Case NNP cord-010119-t1x9gknd 7444 7 Studies Studies NNPS cord-010119-t1x9gknd 7444 8 : : : cord-010119-t1x9gknd 7444 9 Elucidation elucidation NN cord-010119-t1x9gknd 7444 10 of of IN cord-010119-t1x9gknd 7444 11 the the DT cord-010119-t1x9gknd 7444 12 molecular molecular JJ cord-010119-t1x9gknd 7444 13 basis basis NN cord-010119-t1x9gknd 7444 14 of of IN cord-010119-t1x9gknd 7444 15 blood blood NN cord-010119-t1x9gknd 7444 16 group group NN cord-010119-t1x9gknd 7444 17 expression expression NN cord-010119-t1x9gknd 7444 18 has have VBZ cord-010119-t1x9gknd 7444 19 led lead VBN cord-010119-t1x9gknd 7444 20 to to IN cord-010119-t1x9gknd 7444 21 the the DT cord-010119-t1x9gknd 7444 22 development development NN cord-010119-t1x9gknd 7444 23 of of IN cord-010119-t1x9gknd 7444 24 high high JJ cord-010119-t1x9gknd 7444 25 throughput throughput NN cord-010119-t1x9gknd 7444 26 molecular molecular JJ cord-010119-t1x9gknd 7444 27 methods method NNS cord-010119-t1x9gknd 7444 28 for for IN cord-010119-t1x9gknd 7444 29 predicting predict VBG cord-010119-t1x9gknd 7444 30 blood blood NN cord-010119-t1x9gknd 7444 31 group group NN cord-010119-t1x9gknd 7444 32 antigens antigen NNS cord-010119-t1x9gknd 7444 33 . . . cord-010119-t1x9gknd 7445 1 The the DT cord-010119-t1x9gknd 7445 2 commonly commonly RB cord-010119-t1x9gknd 7445 3 used use VBN cord-010119-t1x9gknd 7445 4 single single JJ cord-010119-t1x9gknd 7445 5 nucleotide nucleotide JJ cord-010119-t1x9gknd 7445 6 polymorphism polymorphism NN cord-010119-t1x9gknd 7445 7 ( ( -LRB- cord-010119-t1x9gknd 7445 8 SNP SNP NNP cord-010119-t1x9gknd 7445 9 ) ) -RRB- cord-010119-t1x9gknd 7445 10 arrays array NNS cord-010119-t1x9gknd 7445 11 require require VBP cord-010119-t1x9gknd 7445 12 nucleic nucleic JJ cord-010119-t1x9gknd 7445 13 acid acid NN cord-010119-t1x9gknd 7445 14 isolation isolation NN cord-010119-t1x9gknd 7445 15 which which WDT cord-010119-t1x9gknd 7445 16 is be VBZ cord-010119-t1x9gknd 7445 17 typically typically RB cord-010119-t1x9gknd 7445 18 achieved achieve VBN cord-010119-t1x9gknd 7445 19 by by IN cord-010119-t1x9gknd 7445 20 extracting extract VBG cord-010119-t1x9gknd 7445 21 genomic genomic JJ cord-010119-t1x9gknd 7445 22 DNA dna NN cord-010119-t1x9gknd 7445 23 from from IN cord-010119-t1x9gknd 7445 24 whole whole JJ cord-010119-t1x9gknd 7445 25 blood blood NN cord-010119-t1x9gknd 7445 26 . . . cord-010119-t1x9gknd 7446 1 This this DT cord-010119-t1x9gknd 7446 2 method method NN cord-010119-t1x9gknd 7446 3 requires require VBZ cord-010119-t1x9gknd 7446 4 venipuncture venipuncture NN cord-010119-t1x9gknd 7446 5 and and CC cord-010119-t1x9gknd 7446 6 may may MD cord-010119-t1x9gknd 7446 7 not not RB cord-010119-t1x9gknd 7446 8 be be VB cord-010119-t1x9gknd 7446 9 an an DT cord-010119-t1x9gknd 7446 10 ideal ideal JJ cord-010119-t1x9gknd 7446 11 approach approach NN cord-010119-t1x9gknd 7446 12 for for IN cord-010119-t1x9gknd 7446 13 severely severely RB cord-010119-t1x9gknd 7446 14 anemic anemic JJ cord-010119-t1x9gknd 7446 15 patients patient NNS cord-010119-t1x9gknd 7446 16 or or CC cord-010119-t1x9gknd 7446 17 potential potential JJ cord-010119-t1x9gknd 7446 18 donors donor NNS cord-010119-t1x9gknd 7446 19 that that WDT cord-010119-t1x9gknd 7446 20 are be VBP cord-010119-t1x9gknd 7446 21 unable unable JJ cord-010119-t1x9gknd 7446 22 to to TO cord-010119-t1x9gknd 7446 23 provide provide VB cord-010119-t1x9gknd 7446 24 a a DT cord-010119-t1x9gknd 7446 25 sample sample NN cord-010119-t1x9gknd 7446 26 of of IN cord-010119-t1x9gknd 7446 27 whole whole JJ cord-010119-t1x9gknd 7446 28 blood blood NN cord-010119-t1x9gknd 7446 29 due due IN cord-010119-t1x9gknd 7446 30 to to IN cord-010119-t1x9gknd 7446 31 their -PRON- PRP$ cord-010119-t1x9gknd 7446 32 remote remote JJ cord-010119-t1x9gknd 7446 33 location location NN cord-010119-t1x9gknd 7446 34 . . . cord-010119-t1x9gknd 7447 1 DNA DNA NNP cord-010119-t1x9gknd 7447 2 extracted extract VBN cord-010119-t1x9gknd 7447 3 from from IN cord-010119-t1x9gknd 7447 4 buccal buccal JJ cord-010119-t1x9gknd 7447 5 swab swab NN cord-010119-t1x9gknd 7447 6 samples sample NNS cord-010119-t1x9gknd 7447 7 offers offer VBZ cord-010119-t1x9gknd 7447 8 a a DT cord-010119-t1x9gknd 7447 9 noninvasive noninvasive JJ cord-010119-t1x9gknd 7447 10 alternative alternative NN cord-010119-t1x9gknd 7447 11 to to IN cord-010119-t1x9gknd 7447 12 venipuncture venipuncture NN cord-010119-t1x9gknd 7447 13 and and CC cord-010119-t1x9gknd 7447 14 may may MD cord-010119-t1x9gknd 7447 15 provide provide VB cord-010119-t1x9gknd 7447 16 a a DT cord-010119-t1x9gknd 7447 17 safe safe JJ cord-010119-t1x9gknd 7447 18 and and CC cord-010119-t1x9gknd 7447 19 efficient efficient JJ cord-010119-t1x9gknd 7447 20 means mean NNS cord-010119-t1x9gknd 7447 21 of of IN cord-010119-t1x9gknd 7447 22 transporting transport VBG cord-010119-t1x9gknd 7447 23 samples sample NNS cord-010119-t1x9gknd 7447 24 from from IN cord-010119-t1x9gknd 7447 25 remote remote JJ cord-010119-t1x9gknd 7447 26 locations location NNS cord-010119-t1x9gknd 7447 27 to to TO cord-010119-t1x9gknd 7447 28 reference reference VB cord-010119-t1x9gknd 7447 29 laboratories laboratory NNS cord-010119-t1x9gknd 7447 30 for for IN cord-010119-t1x9gknd 7447 31 extended extended JJ cord-010119-t1x9gknd 7447 32 blood blood NN cord-010119-t1x9gknd 7447 33 type type NN cord-010119-t1x9gknd 7447 34 prediction prediction NN cord-010119-t1x9gknd 7447 35 . . . cord-010119-t1x9gknd 7448 1 Canadian Canadian NNP cord-010119-t1x9gknd 7448 2 Blood Blood NNP cord-010119-t1x9gknd 7448 3 Services Services NNPS cord-010119-t1x9gknd 7448 4 ( ( -LRB- cord-010119-t1x9gknd 7448 5 CBS CBS NNP cord-010119-t1x9gknd 7448 6 ) ) -RRB- cord-010119-t1x9gknd 7448 7 has have VBZ cord-010119-t1x9gknd 7448 8 performed perform VBN cord-010119-t1x9gknd 7448 9 large large JJ cord-010119-t1x9gknd 7448 10 scale scale NN cord-010119-t1x9gknd 7448 11 DNA dna NN cord-010119-t1x9gknd 7448 12 extraction extraction NN cord-010119-t1x9gknd 7448 13 and and CC cord-010119-t1x9gknd 7448 14 HLA HLA NNP cord-010119-t1x9gknd 7448 15 genotyping genotype VBG cord-010119-t1x9gknd 7448 16 for for IN cord-010119-t1x9gknd 7448 17 the the DT cord-010119-t1x9gknd 7448 18 OneMatch OneMatch NNP cord-010119-t1x9gknd 7448 19 Stem Stem NNP cord-010119-t1x9gknd 7448 20 Cell Cell NNP cord-010119-t1x9gknd 7448 21 and and CC cord-010119-t1x9gknd 7448 22 Marrow Marrow NNP cord-010119-t1x9gknd 7448 23 Registry Registry NNP cord-010119-t1x9gknd 7448 24 using use VBG cord-010119-t1x9gknd 7448 25 buccal buccal JJ cord-010119-t1x9gknd 7448 26 swabs swab NNS cord-010119-t1x9gknd 7448 27 since since IN cord-010119-t1x9gknd 7448 28 2007 2007 CD cord-010119-t1x9gknd 7448 29 ; ; , cord-010119-t1x9gknd 7448 30 buccal buccal JJ cord-010119-t1x9gknd 7448 31 swabs swab NNS cord-010119-t1x9gknd 7448 32 are be VBP cord-010119-t1x9gknd 7448 33 also also RB cord-010119-t1x9gknd 7448 34 used use VBN cord-010119-t1x9gknd 7448 35 by by IN cord-010119-t1x9gknd 7448 36 other other JJ cord-010119-t1x9gknd 7448 37 unrelated unrelated JJ cord-010119-t1x9gknd 7448 38 donor donor NN cord-010119-t1x9gknd 7448 39 stem stem NN cord-010119-t1x9gknd 7448 40 cell cell NN cord-010119-t1x9gknd 7448 41 registries registry NNS cord-010119-t1x9gknd 7448 42 , , , cord-010119-t1x9gknd 7448 43 such such JJ cord-010119-t1x9gknd 7448 44 as as IN cord-010119-t1x9gknd 7448 45 the the DT cord-010119-t1x9gknd 7448 46 US US NNP cord-010119-t1x9gknd 7448 47 NMPD NMPD NNP cord-010119-t1x9gknd 7448 48 . . . cord-010119-t1x9gknd 7449 1 We -PRON- PRP cord-010119-t1x9gknd 7449 2 sought seek VBD cord-010119-t1x9gknd 7449 3 to to TO cord-010119-t1x9gknd 7449 4 assess assess VB cord-010119-t1x9gknd 7449 5 the the DT cord-010119-t1x9gknd 7449 6 accuracy accuracy NN cord-010119-t1x9gknd 7449 7 and and CC cord-010119-t1x9gknd 7449 8 reliability reliability NN cord-010119-t1x9gknd 7449 9 of of IN cord-010119-t1x9gknd 7449 10 using use VBG cord-010119-t1x9gknd 7449 11 DNA dna NN cord-010119-t1x9gknd 7449 12 extracted extract VBN cord-010119-t1x9gknd 7449 13 from from IN cord-010119-t1x9gknd 7449 14 buccal buccal JJ cord-010119-t1x9gknd 7449 15 swabs swab NNS cord-010119-t1x9gknd 7449 16 in in IN cord-010119-t1x9gknd 7449 17 predicting predict VBG cord-010119-t1x9gknd 7449 18 blood blood NN cord-010119-t1x9gknd 7449 19 group group NN cord-010119-t1x9gknd 7449 20 antigen antigen NN cord-010119-t1x9gknd 7449 21 expression expression NN cord-010119-t1x9gknd 7449 22 . . . cord-010119-t1x9gknd 7450 1 Study Study NNP cord-010119-t1x9gknd 7450 2 Design Design NNP cord-010119-t1x9gknd 7450 3 / / SYM cord-010119-t1x9gknd 7450 4 Method method NN cord-010119-t1x9gknd 7450 5 : : : cord-010119-t1x9gknd 7450 6 We -PRON- PRP cord-010119-t1x9gknd 7450 7 performed perform VBD cord-010119-t1x9gknd 7450 8 parallel parallel JJ cord-010119-t1x9gknd 7450 9 red red JJ cord-010119-t1x9gknd 7450 10 cell cell NN cord-010119-t1x9gknd 7450 11 genotyping genotyping NN cord-010119-t1x9gknd 7450 12 on on IN cord-010119-t1x9gknd 7450 13 an an DT cord-010119-t1x9gknd 7450 14 automated automated JJ cord-010119-t1x9gknd 7450 15 typing typing NN cord-010119-t1x9gknd 7450 16 platform platform NN cord-010119-t1x9gknd 7450 17 , , , cord-010119-t1x9gknd 7450 18 the the DT cord-010119-t1x9gknd 7450 19 Progenika Progenika NNP cord-010119-t1x9gknd 7450 20 / / SYM cord-010119-t1x9gknd 7450 21 Grifols Grifols NNP cord-010119-t1x9gknd 7450 22 IDCoreXT IDCoreXT NNP cord-010119-t1x9gknd 7450 23 assay assay NN cord-010119-t1x9gknd 7450 24 ( ( -LRB- cord-010119-t1x9gknd 7450 25 Progenika Progenika NNP cord-010119-t1x9gknd 7450 26 Biopharma Biopharma NNP cord-010119-t1x9gknd 7450 27 - - HYPH cord-010119-t1x9gknd 7450 28 Grifols Grifols NNP cord-010119-t1x9gknd 7450 29 , , , cord-010119-t1x9gknd 7450 30 Bizkaia Bizkaia NNP cord-010119-t1x9gknd 7450 31 , , , cord-010119-t1x9gknd 7450 32 Spain Spain NNP cord-010119-t1x9gknd 7450 33 ) ) -RRB- cord-010119-t1x9gknd 7450 34 using use VBG cord-010119-t1x9gknd 7450 35 DNA dna NN cord-010119-t1x9gknd 7450 36 extracted extract VBN cord-010119-t1x9gknd 7450 37 from from IN cord-010119-t1x9gknd 7450 38 blood blood NN cord-010119-t1x9gknd 7450 39 and and CC cord-010119-t1x9gknd 7450 40 buccal buccal JJ cord-010119-t1x9gknd 7450 41 tissue tissue NN cord-010119-t1x9gknd 7450 42 from from IN cord-010119-t1x9gknd 7450 43 volunteers volunteer NNS cord-010119-t1x9gknd 7450 44 . . . cord-010119-t1x9gknd 7451 1 For for IN cord-010119-t1x9gknd 7451 2 antigen antigen NN cord-010119-t1x9gknd 7451 3 systems system NNS cord-010119-t1x9gknd 7451 4 with with IN cord-010119-t1x9gknd 7451 5 available available JJ cord-010119-t1x9gknd 7451 6 serologic serologic JJ cord-010119-t1x9gknd 7451 7 reagents reagent NNS cord-010119-t1x9gknd 7451 8 , , , cord-010119-t1x9gknd 7451 9 we -PRON- PRP cord-010119-t1x9gknd 7451 10 also also RB cord-010119-t1x9gknd 7451 11 compared compare VBD cord-010119-t1x9gknd 7451 12 results result NNS cord-010119-t1x9gknd 7451 13 with with IN cord-010119-t1x9gknd 7451 14 serologic serologic NN cord-010119-t1x9gknd 7451 15 typing typing NN cord-010119-t1x9gknd 7451 16 . . . cord-010119-t1x9gknd 7452 1 We -PRON- PRP cord-010119-t1x9gknd 7452 2 evaluated evaluate VBD cord-010119-t1x9gknd 7452 3 three three CD cord-010119-t1x9gknd 7452 4 different different JJ cord-010119-t1x9gknd 7452 5 methods method NNS cord-010119-t1x9gknd 7452 6 of of IN cord-010119-t1x9gknd 7452 7 DNA dna NN cord-010119-t1x9gknd 7452 8 extraction extraction NN cord-010119-t1x9gknd 7452 9 and and CC cord-010119-t1x9gknd 7452 10 performed perform VBN cord-010119-t1x9gknd 7452 11 testing test VBG cord-010119-t1x9gknd 7452 12 regardless regardless RB cord-010119-t1x9gknd 7452 13 of of IN cord-010119-t1x9gknd 7452 14 DNA dna NN cord-010119-t1x9gknd 7452 15 yield yield NN cord-010119-t1x9gknd 7452 16 or or CC cord-010119-t1x9gknd 7452 17 purity purity NN cord-010119-t1x9gknd 7452 18 . . . cord-010119-t1x9gknd 7453 1 Two two CD cord-010119-t1x9gknd 7453 2 buccal buccal JJ cord-010119-t1x9gknd 7453 3 swabs swab NNS cord-010119-t1x9gknd 7453 4 ( ( -LRB- cord-010119-t1x9gknd 7453 5 Puritan Puritan NNP cord-010119-t1x9gknd 7453 6 Medical Medical NNP cord-010119-t1x9gknd 7453 7 Products Products NNPS cord-010119-t1x9gknd 7453 8 , , , cord-010119-t1x9gknd 7453 9 Guilford Guilford NNP cord-010119-t1x9gknd 7453 10 , , , cord-010119-t1x9gknd 7453 11 Maine Maine NNP cord-010119-t1x9gknd 7453 12 ) ) -RRB- cord-010119-t1x9gknd 7453 13 were be VBD cord-010119-t1x9gknd 7453 14 used use VBN cord-010119-t1x9gknd 7453 15 for for IN cord-010119-t1x9gknd 7453 16 each each DT cord-010119-t1x9gknd 7453 17 test test NN cord-010119-t1x9gknd 7453 18 . . . cord-010119-t1x9gknd 7454 1 Swabs swab NNS cord-010119-t1x9gknd 7454 2 were be VBD cord-010119-t1x9gknd 7454 3 stored store VBN cord-010119-t1x9gknd 7454 4 at at IN cord-010119-t1x9gknd 7454 5 room room NN cord-010119-t1x9gknd 7454 6 temperature temperature NN cord-010119-t1x9gknd 7454 7 , , , cord-010119-t1x9gknd 7454 8 and and CC cord-010119-t1x9gknd 7454 9 DNA dna NN cord-010119-t1x9gknd 7454 10 extraction extraction NN cord-010119-t1x9gknd 7454 11 was be VBD cord-010119-t1x9gknd 7454 12 performed perform VBN cord-010119-t1x9gknd 7454 13 within within IN cord-010119-t1x9gknd 7454 14 six six CD cord-010119-t1x9gknd 7454 15 days day NNS cord-010119-t1x9gknd 7454 16 of of IN cord-010119-t1x9gknd 7454 17 collection collection NN cord-010119-t1x9gknd 7454 18 . . . cord-010119-t1x9gknd 7455 1 In in IN cord-010119-t1x9gknd 7455 2 the the DT cord-010119-t1x9gknd 7455 3 initial initial JJ cord-010119-t1x9gknd 7455 4 phase phase NN cord-010119-t1x9gknd 7455 5 of of IN cord-010119-t1x9gknd 7455 6 the the DT cord-010119-t1x9gknd 7455 7 study study NN cord-010119-t1x9gknd 7455 8 , , , cord-010119-t1x9gknd 7455 9 buccal buccal JJ cord-010119-t1x9gknd 7455 10 swab swab NN cord-010119-t1x9gknd 7455 11 samples sample NNS cord-010119-t1x9gknd 7455 12 ( ( -LRB- cord-010119-t1x9gknd 7455 13 n n NN cord-010119-t1x9gknd 7455 14 5 5 CD cord-010119-t1x9gknd 7455 15 15 15 CD cord-010119-t1x9gknd 7455 16 ) ) -RRB- cord-010119-t1x9gknd 7455 17 were be VBD cord-010119-t1x9gknd 7455 18 processed process VBN cord-010119-t1x9gknd 7455 19 with with IN cord-010119-t1x9gknd 7455 20 the the DT cord-010119-t1x9gknd 7455 21 automated automate VBN cord-010119-t1x9gknd 7455 22 Biorobot Biorobot NNP cord-010119-t1x9gknd 7455 23 M48 M48 NNP cord-010119-t1x9gknd 7455 24 Robot Robot NNP cord-010119-t1x9gknd 7455 25 using use VBG cord-010119-t1x9gknd 7455 26 the the DT cord-010119-t1x9gknd 7455 27 MagAttract MagAttract NNP cord-010119-t1x9gknd 7455 28 DNA DNA NNP cord-010119-t1x9gknd 7455 29 Mini Mini NNP cord-010119-t1x9gknd 7455 30 M48 M48 NNP cord-010119-t1x9gknd 7455 31 extraction extraction NN cord-010119-t1x9gknd 7455 32 method method NN cord-010119-t1x9gknd 7455 33 ( ( -LRB- cord-010119-t1x9gknd 7455 34 Qiagen Qiagen NNP cord-010119-t1x9gknd 7455 35 , , , cord-010119-t1x9gknd 7455 36 Venlo Venlo NNP cord-010119-t1x9gknd 7455 37 , , , cord-010119-t1x9gknd 7455 38 the the DT cord-010119-t1x9gknd 7455 39 Netherlands Netherlands NNP cord-010119-t1x9gknd 7455 40 ) ) -RRB- cord-010119-t1x9gknd 7455 41 . . . cord-010119-t1x9gknd 7456 1 Extracted extract VBN cord-010119-t1x9gknd 7456 2 DNA DNA NNP cord-010119-t1x9gknd 7456 3 had have VBD cord-010119-t1x9gknd 7456 4 a a DT cord-010119-t1x9gknd 7456 5 mean mean JJ cord-010119-t1x9gknd 7456 6 concentration concentration NN cord-010119-t1x9gknd 7456 7 and and CC cord-010119-t1x9gknd 7456 8 purity purity NN cord-010119-t1x9gknd 7456 9 of of IN cord-010119-t1x9gknd 7456 10 38.1ng 38.1ng NNP cord-010119-t1x9gknd 7456 11 / / SYM cord-010119-t1x9gknd 7456 12 ml ml NN cord-010119-t1x9gknd 7456 13 and and CC cord-010119-t1x9gknd 7456 14 1.83 1.83 CD cord-010119-t1x9gknd 7456 15 respectively respectively RB cord-010119-t1x9gknd 7456 16 . . . cord-010119-t1x9gknd 7457 1 In in IN cord-010119-t1x9gknd 7457 2 the the DT cord-010119-t1x9gknd 7457 3 second second JJ cord-010119-t1x9gknd 7457 4 phase phase NN cord-010119-t1x9gknd 7457 5 of of IN cord-010119-t1x9gknd 7457 6 the the DT cord-010119-t1x9gknd 7457 7 study study NN cord-010119-t1x9gknd 7457 8 ( ( -LRB- cord-010119-t1x9gknd 7457 9 n n NN cord-010119-t1x9gknd 7457 10 5 5 CD cord-010119-t1x9gknd 7457 11 39 39 CD cord-010119-t1x9gknd 7457 12 ) ) -RRB- cord-010119-t1x9gknd 7457 13 , , , cord-010119-t1x9gknd 7457 14 DNA dna NN cord-010119-t1x9gknd 7457 15 extractions extraction NNS cord-010119-t1x9gknd 7457 16 from from IN cord-010119-t1x9gknd 7457 17 buccal buccal JJ cord-010119-t1x9gknd 7457 18 swabs swab NNS cord-010119-t1x9gknd 7457 19 were be VBD cord-010119-t1x9gknd 7457 20 performed perform VBN cord-010119-t1x9gknd 7457 21 using use VBG cord-010119-t1x9gknd 7457 22 methods method NNS cord-010119-t1x9gknd 7457 23 available available JJ cord-010119-t1x9gknd 7457 24 in in IN cord-010119-t1x9gknd 7457 25 our -PRON- PRP$ cord-010119-t1x9gknd 7457 26 national national JJ cord-010119-t1x9gknd 7457 27 red red JJ cord-010119-t1x9gknd 7457 28 cell cell NN cord-010119-t1x9gknd 7457 29 immunohematology immunohematology NN cord-010119-t1x9gknd 7457 30 reference reference NN cord-010119-t1x9gknd 7457 31 laboratory laboratory NN cord-010119-t1x9gknd 7457 32 : : : cord-010119-t1x9gknd 7457 33 the the DT cord-010119-t1x9gknd 7457 34 QIAamp QIAamp NNP cord-010119-t1x9gknd 7457 35 DNA dna NN cord-010119-t1x9gknd 7457 36 mini mini NN cord-010119-t1x9gknd 7457 37 kit kit NN cord-010119-t1x9gknd 7457 38 , , , cord-010119-t1x9gknd 7457 39 using use VBG cord-010119-t1x9gknd 7457 40 either either CC cord-010119-t1x9gknd 7457 41 manual manual NN cord-010119-t1x9gknd 7457 42 or or CC cord-010119-t1x9gknd 7457 43 an an DT cord-010119-t1x9gknd 7457 44 automated automate VBN cord-010119-t1x9gknd 7457 45 QiaCube QiaCube NNP cord-010119-t1x9gknd 7457 46 robotic robotic JJ cord-010119-t1x9gknd 7457 47 workstation workstation NN cord-010119-t1x9gknd 7457 48 ( ( -LRB- cord-010119-t1x9gknd 7457 49 Qiagen Qiagen NNP cord-010119-t1x9gknd 7457 50 , , , cord-010119-t1x9gknd 7457 51 Venlo Venlo NNP cord-010119-t1x9gknd 7457 52 , , , cord-010119-t1x9gknd 7457 53 the the DT cord-010119-t1x9gknd 7457 54 Netherlands Netherlands NNP cord-010119-t1x9gknd 7457 55 ) ) -RRB- cord-010119-t1x9gknd 7457 56 . . . cord-010119-t1x9gknd 7458 1 Results/ Results/ . cord-010119-t1x9gknd 7459 1 Finding finding NN cord-010119-t1x9gknd 7459 2 : : : cord-010119-t1x9gknd 7460 1 The the DT cord-010119-t1x9gknd 7460 2 manufacturer manufacturer NN cord-010119-t1x9gknd 7460 3 's 's POS cord-010119-t1x9gknd 7460 4 recommended recommend VBN cord-010119-t1x9gknd 7460 5 analytical analytical JJ cord-010119-t1x9gknd 7460 6 range range NN cord-010119-t1x9gknd 7460 7 for for IN cord-010119-t1x9gknd 7460 8 DNA dna NN cord-010119-t1x9gknd 7460 9 concentration concentration NN cord-010119-t1x9gknd 7460 10 was be VBD cord-010119-t1x9gknd 7460 11 20 20 CD cord-010119-t1x9gknd 7460 12 - - HYPH cord-010119-t1x9gknd 7460 13 80ng 80ng NN cord-010119-t1x9gknd 7460 14 / / SYM cord-010119-t1x9gknd 7460 15 ll ll VB cord-010119-t1x9gknd 7460 16 and and CC cord-010119-t1x9gknd 7460 17 the the DT cord-010119-t1x9gknd 7460 18 recommended recommend VBN cord-010119-t1x9gknd 7460 19 purity purity NN cord-010119-t1x9gknd 7460 20 was be VBD cord-010119-t1x9gknd 7460 21 an an DT cord-010119-t1x9gknd 7460 22 absorbance absorbance NN cord-010119-t1x9gknd 7460 23 ratio ratio NN cord-010119-t1x9gknd 7460 24 of of IN cord-010119-t1x9gknd 7460 25 1.63 1.63 CD cord-010119-t1x9gknd 7460 26 - - SYM cord-010119-t1x9gknd 7460 27 2.1 2.1 CD cord-010119-t1x9gknd 7460 28 ( ( -LRB- cord-010119-t1x9gknd 7460 29 A260/280 A260/280 NNP cord-010119-t1x9gknd 7460 30 ) ) -RRB- cord-010119-t1x9gknd 7460 31 for for IN cord-010119-t1x9gknd 7460 32 use use NN cord-010119-t1x9gknd 7460 33 of of IN cord-010119-t1x9gknd 7460 34 the the DT cord-010119-t1x9gknd 7460 35 ID ID NNP cord-010119-t1x9gknd 7460 36 CoreXT CoreXT NNP cord-010119-t1x9gknd 7460 37 platform platform NN cord-010119-t1x9gknd 7460 38 . . . cord-010119-t1x9gknd 7461 1 DNA dna NN cord-010119-t1x9gknd 7461 2 extraction extraction NN cord-010119-t1x9gknd 7461 3 from from IN cord-010119-t1x9gknd 7461 4 buccal buccal JJ cord-010119-t1x9gknd 7461 5 swab swab NN cord-010119-t1x9gknd 7461 6 samples sample NNS cord-010119-t1x9gknd 7461 7 did do VBD cord-010119-t1x9gknd 7461 8 not not RB cord-010119-t1x9gknd 7461 9 meet meet VB cord-010119-t1x9gknd 7461 10 these these DT cord-010119-t1x9gknd 7461 11 specifications specification NNS cord-010119-t1x9gknd 7461 12 in in IN cord-010119-t1x9gknd 7461 13 several several JJ cord-010119-t1x9gknd 7461 14 cases case NNS cord-010119-t1x9gknd 7461 15 . . . cord-010119-t1x9gknd 7462 1 However however RB cord-010119-t1x9gknd 7462 2 , , , cord-010119-t1x9gknd 7462 3 in in IN cord-010119-t1x9gknd 7462 4 most most JJS cord-010119-t1x9gknd 7462 5 cases case NNS cord-010119-t1x9gknd 7462 6 , , , cord-010119-t1x9gknd 7462 7 a a DT cord-010119-t1x9gknd 7462 8 lower low JJR cord-010119-t1x9gknd 7462 9 concentration concentration NN cord-010119-t1x9gknd 7462 10 of of IN cord-010119-t1x9gknd 7462 11 DNA DNA NNP cord-010119-t1x9gknd 7462 12 was be VBD cord-010119-t1x9gknd 7462 13 adequate adequate JJ cord-010119-t1x9gknd 7462 14 for for IN cord-010119-t1x9gknd 7462 15 prediction prediction NN cord-010119-t1x9gknd 7462 16 of of IN cord-010119-t1x9gknd 7462 17 phenotype phenotype NN cord-010119-t1x9gknd 7462 18 . . . cord-010119-t1x9gknd 7463 1 The the DT cord-010119-t1x9gknd 7463 2 Dombrock Dombrock NNP cord-010119-t1x9gknd 7463 3 system system NN cord-010119-t1x9gknd 7463 4 was be VBD cord-010119-t1x9gknd 7463 5 the the DT cord-010119-t1x9gknd 7463 6 most most RBS cord-010119-t1x9gknd 7463 7 susceptible susceptible JJ cord-010119-t1x9gknd 7463 8 to to IN cord-010119-t1x9gknd 7463 9 failure failure NN cord-010119-t1x9gknd 7463 10 of of IN cord-010119-t1x9gknd 7463 11 interpretation interpretation NN cord-010119-t1x9gknd 7463 12 in in IN cord-010119-t1x9gknd 7463 13 the the DT cord-010119-t1x9gknd 7463 14 samples sample NNS cord-010119-t1x9gknd 7463 15 with with IN cord-010119-t1x9gknd 7463 16 a a DT cord-010119-t1x9gknd 7463 17 low low JJ cord-010119-t1x9gknd 7463 18 DNA dna NN cord-010119-t1x9gknd 7463 19 concentration concentration NN cord-010119-t1x9gknd 7463 20 , , , cord-010119-t1x9gknd 7463 21 with with IN cord-010119-t1x9gknd 7463 22 " " `` cord-010119-t1x9gknd 7463 23 no no DT cord-010119-t1x9gknd 7463 24 call call NN cord-010119-t1x9gknd 7463 25 " " '' cord-010119-t1x9gknd 7463 26 results result NNS cord-010119-t1x9gknd 7463 27 reported report VBN cord-010119-t1x9gknd 7463 28 . . . cord-010119-t1x9gknd 7464 1 There there EX cord-010119-t1x9gknd 7464 2 was be VBD cord-010119-t1x9gknd 7464 3 100 100 CD cord-010119-t1x9gknd 7464 4 % % NN cord-010119-t1x9gknd 7464 5 concordance concordance NN cord-010119-t1x9gknd 7464 6 in in IN cord-010119-t1x9gknd 7464 7 genotyping genotyping NN cord-010119-t1x9gknd 7464 8 results result NNS cord-010119-t1x9gknd 7464 9 when when WRB cord-010119-t1x9gknd 7464 10 source source NN cord-010119-t1x9gknd 7464 11 DNA dna NN cord-010119-t1x9gknd 7464 12 was be VBD cord-010119-t1x9gknd 7464 13 extracted extract VBN cord-010119-t1x9gknd 7464 14 from from IN cord-010119-t1x9gknd 7464 15 whole whole JJ cord-010119-t1x9gknd 7464 16 blood blood NN cord-010119-t1x9gknd 7464 17 or or CC cord-010119-t1x9gknd 7464 18 buccal buccal JJ cord-010119-t1x9gknd 7464 19 tissue tissue NN cord-010119-t1x9gknd 7464 20 ; ; : cord-010119-t1x9gknd 7464 21 there there EX cord-010119-t1x9gknd 7464 22 was be VBD cord-010119-t1x9gknd 7464 23 also also RB cord-010119-t1x9gknd 7464 24 100 100 CD cord-010119-t1x9gknd 7464 25 % % NN cord-010119-t1x9gknd 7464 26 concordance concordance NN cord-010119-t1x9gknd 7464 27 between between IN cord-010119-t1x9gknd 7464 28 predicted predict VBN cord-010119-t1x9gknd 7464 29 phenotype phenotype NN cord-010119-t1x9gknd 7464 30 and and CC cord-010119-t1x9gknd 7464 31 serologic serologic NN cord-010119-t1x9gknd 7464 32 testing testing NN cord-010119-t1x9gknd 7464 33 results result NNS cord-010119-t1x9gknd 7464 34 . . . cord-010119-t1x9gknd 7465 1 Conclusion conclusion NN cord-010119-t1x9gknd 7465 2 : : : cord-010119-t1x9gknd 7466 1 This this DT cord-010119-t1x9gknd 7466 2 study study NN cord-010119-t1x9gknd 7466 3 supports support VBZ cord-010119-t1x9gknd 7466 4 the the DT cord-010119-t1x9gknd 7466 5 use use NN cord-010119-t1x9gknd 7466 6 of of IN cord-010119-t1x9gknd 7466 7 genomic genomic JJ cord-010119-t1x9gknd 7466 8 DNA dna NN cord-010119-t1x9gknd 7466 9 extracted extract VBN cord-010119-t1x9gknd 7466 10 from from IN cord-010119-t1x9gknd 7466 11 buccal buccal JJ cord-010119-t1x9gknd 7466 12 tissue tissue NN cord-010119-t1x9gknd 7466 13 on on IN cord-010119-t1x9gknd 7466 14 the the DT cord-010119-t1x9gknd 7466 15 ID ID NNP cord-010119-t1x9gknd 7466 16 CoreXT CoreXT NNP cord-010119-t1x9gknd 7466 17 for for IN cord-010119-t1x9gknd 7466 18 predicting predict VBG cord-010119-t1x9gknd 7466 19 RBC RBC NNP cord-010119-t1x9gknd 7466 20 phenotype phenotype NN cord-010119-t1x9gknd 7466 21 with with IN cord-010119-t1x9gknd 7466 22 high high JJ cord-010119-t1x9gknd 7466 23 accuracy accuracy NN cord-010119-t1x9gknd 7466 24 . . . cord-010119-t1x9gknd 7467 1 Extraction extraction NN cord-010119-t1x9gknd 7467 2 methods method NNS cord-010119-t1x9gknd 7467 3 may may MD cord-010119-t1x9gknd 7467 4 require require VB cord-010119-t1x9gknd 7467 5 optimization optimization NN cord-010119-t1x9gknd 7467 6 to to TO cord-010119-t1x9gknd 7467 7 achieve achieve VB cord-010119-t1x9gknd 7467 8 DNA dna NN cord-010119-t1x9gknd 7467 9 yields yield NNS cord-010119-t1x9gknd 7467 10 within within IN cord-010119-t1x9gknd 7467 11 the the DT cord-010119-t1x9gknd 7467 12 recommended recommend VBN cord-010119-t1x9gknd 7467 13 analytical analytical JJ cord-010119-t1x9gknd 7467 14 range range NN cord-010119-t1x9gknd 7467 15 of of IN cord-010119-t1x9gknd 7467 16 the the DT cord-010119-t1x9gknd 7467 17 assay assay NN cord-010119-t1x9gknd 7467 18 . . . cord-010119-t1x9gknd 7468 1 Performance Performance NNP cord-010119-t1x9gknd 7468 2 Evaluation Evaluation NNP cord-010119-t1x9gknd 7468 3 of of IN cord-010119-t1x9gknd 7468 4 ID ID NNP cord-010119-t1x9gknd 7468 5 RHD RHD NNP cord-010119-t1x9gknd 7468 6 XT XT NNP cord-010119-t1x9gknd 7468 7 , , , cord-010119-t1x9gknd 7468 8 a a DT cord-010119-t1x9gknd 7468 9 Genotyping Genotyping NNP cord-010119-t1x9gknd 7468 10 Assay Assay NNP cord-010119-t1x9gknd 7468 11 for for IN cord-010119-t1x9gknd 7468 12 the the DT cord-010119-t1x9gknd 7468 13 Detection Detection NNP cord-010119-t1x9gknd 7468 14 of of IN cord-010119-t1x9gknd 7468 15 High high JJ cord-010119-t1x9gknd 7468 16 - - HYPH cord-010119-t1x9gknd 7468 17 Prevalence prevalence NN cord-010119-t1x9gknd 7468 18 RHD rhd NN cord-010119-t1x9gknd 7468 19 Negative negative JJ cord-010119-t1x9gknd 7468 20 and and CC cord-010119-t1x9gknd 7469 1 Weak weak JJ cord-010119-t1x9gknd 7469 2 D d NN cord-010119-t1x9gknd 7469 3 Types type NNS cord-010119-t1x9gknd 7469 4 Araitz Araitz NNP cord-010119-t1x9gknd 7469 5 Molano Molano NNP cord-010119-t1x9gknd 7469 6 1 1 CD cord-010119-t1x9gknd 7469 7 , , , cord-010119-t1x9gknd 7469 8 Izaskun Izaskun NNP cord-010119-t1x9gknd 7469 9 Apraiz Apraiz NNP cord-010119-t1x9gknd 7469 10 1 1 CD cord-010119-t1x9gknd 7469 11 , , , cord-010119-t1x9gknd 7469 12 María María NNP cord-010119-t1x9gknd 7469 13 Azcarate Azcarate NNP cord-010119-t1x9gknd 7469 14 2 2 CD cord-010119-t1x9gknd 7469 15 , , , cord-010119-t1x9gknd 7469 16 Miguel Miguel NNP cord-010119-t1x9gknd 7469 17 Angel Angel NNP cord-010119-t1x9gknd 7469 18 Vesga Vesga NNP cord-010119-t1x9gknd 7469 19 2 2 CD cord-010119-t1x9gknd 7469 20 , , , cord-010119-t1x9gknd 7469 21 Montserrat Montserrat NNP cord-010119-t1x9gknd 7469 22 Rubia Rubia NNP cord-010119-t1x9gknd 7469 23 2 2 CD cord-010119-t1x9gknd 7469 24 , , , cord-010119-t1x9gknd 7469 25 Mercedes Mercedes NNP cord-010119-t1x9gknd 7469 26 Piedrabuena Piedrabuena NNP cord-010119-t1x9gknd 7469 27 2 2 CD cord-010119-t1x9gknd 7469 28 , , , cord-010119-t1x9gknd 7469 29 Fernando Fernando NNP cord-010119-t1x9gknd 7469 30 Puente Puente NNP cord-010119-t1x9gknd 7469 31 3 3 CD cord-010119-t1x9gknd 7469 32 , , , cord-010119-t1x9gknd 7469 33 Barbera Barbera NNP cord-010119-t1x9gknd 7469 34 Veldhuisen Veldhuisen NNP cord-010119-t1x9gknd 7469 35 4 4 CD cord-010119-t1x9gknd 7469 36 , , , cord-010119-t1x9gknd 7469 37 Ellen Ellen NNP cord-010119-t1x9gknd 7469 38 Van Van NNP cord-010119-t1x9gknd 7469 39 Der Der NNP cord-010119-t1x9gknd 7469 40 Schoot Schoot NNP cord-010119-t1x9gknd 7469 41 4 4 CD cord-010119-t1x9gknd 7469 42 and and CC cord-010119-t1x9gknd 7469 43 M M NNP cord-010119-t1x9gknd 7469 44 onica onica NNP cord-010119-t1x9gknd 7469 45 L L NNP cord-010119-t1x9gknd 7469 46 opez opez NNP cord-010119-t1x9gknd 7469 47 * * NFP cord-010119-t1x9gknd 7469 48 1 1 CD cord-010119-t1x9gknd 7469 49 . . . cord-010119-t1x9gknd 7470 1 1 1 LS cord-010119-t1x9gknd 7471 1 Progenika Progenika NNP cord-010119-t1x9gknd 7471 2 Biopharma Biopharma NNP cord-010119-t1x9gknd 7471 3 , , , cord-010119-t1x9gknd 7471 4 a a DT cord-010119-t1x9gknd 7471 5 Grifols Grifols NNP cord-010119-t1x9gknd 7471 6 Company Company NNP cord-010119-t1x9gknd 7471 7 , , , cord-010119-t1x9gknd 7471 8 2 2 CD cord-010119-t1x9gknd 7471 9 Centro Centro NNP cord-010119-t1x9gknd 7471 10 Vasco Vasco NNP cord-010119-t1x9gknd 7471 11 de de NNP cord-010119-t1x9gknd 7471 12 Transfusi Transfusi NNP cord-010119-t1x9gknd 7471 13 on on IN cord-010119-t1x9gknd 7471 14 y y NNP cord-010119-t1x9gknd 7471 15 Tejidos Tejidos NNP cord-010119-t1x9gknd 7471 16 Humanos Humanos NNP cord-010119-t1x9gknd 7471 17 , , , cord-010119-t1x9gknd 7471 18 3 3 CD cord-010119-t1x9gknd 7471 19 Banco Banco NNP cord-010119-t1x9gknd 7471 20 de de NNP cord-010119-t1x9gknd 7471 21 Sangre Sangre NNP cord-010119-t1x9gknd 7471 22 y y NNP cord-010119-t1x9gknd 7471 23 Tejidos Tejidos NNP cord-010119-t1x9gknd 7471 24 de de NNP cord-010119-t1x9gknd 7471 25 Arag Arag NNP cord-010119-t1x9gknd 7471 26 on on IN cord-010119-t1x9gknd 7471 27 , , , cord-010119-t1x9gknd 7471 28 4 4 CD cord-010119-t1x9gknd 7471 29 Sanquin Sanquin NNP cord-010119-t1x9gknd 7471 30 Blood Blood NNP cord-010119-t1x9gknd 7471 31 Supply Supply NNP cord-010119-t1x9gknd 7471 32 Research Research NNP cord-010119-t1x9gknd 7471 33 Background Background NNP cord-010119-t1x9gknd 7471 34 / / SYM cord-010119-t1x9gknd 7471 35 Case Case NNP cord-010119-t1x9gknd 7471 36 Studies Studies NNPS cord-010119-t1x9gknd 7471 37 : : : cord-010119-t1x9gknd 7472 1 It -PRON- PRP cord-010119-t1x9gknd 7472 2 is be VBZ cord-010119-t1x9gknd 7472 3 well well RB cord-010119-t1x9gknd 7472 4 established establish VBN cord-010119-t1x9gknd 7472 5 that that IN cord-010119-t1x9gknd 7472 6 weak weak JJ cord-010119-t1x9gknd 7472 7 D D NNP cord-010119-t1x9gknd 7472 8 1 1 CD cord-010119-t1x9gknd 7472 9 , , , cord-010119-t1x9gknd 7472 10 2 2 CD cord-010119-t1x9gknd 7472 11 and and CC cord-010119-t1x9gknd 7472 12 3 3 CD cord-010119-t1x9gknd 7472 13 phenotypes phenotype NNS cord-010119-t1x9gknd 7472 14 are be VBP cord-010119-t1x9gknd 7472 15 not not RB cord-010119-t1x9gknd 7472 16 at at IN cord-010119-t1x9gknd 7472 17 risk risk NN cord-010119-t1x9gknd 7472 18 for for IN cord-010119-t1x9gknd 7472 19 forming form VBG cord-010119-t1x9gknd 7472 20 allo allo VB cord-010119-t1x9gknd 7472 21 - - HYPH cord-010119-t1x9gknd 7472 22 anti anti NN cord-010119-t1x9gknd 7472 23 - - JJ cord-010119-t1x9gknd 7472 24 D d JJ cord-010119-t1x9gknd 7472 25 , , , cord-010119-t1x9gknd 7472 26 whereas whereas IN cord-010119-t1x9gknd 7472 27 a a DT cord-010119-t1x9gknd 7472 28 few few JJ cord-010119-t1x9gknd 7472 29 weak weak JJ cord-010119-t1x9gknd 7472 30 D d NN cord-010119-t1x9gknd 7472 31 and and CC cord-010119-t1x9gknd 7472 32 all all DT cord-010119-t1x9gknd 7472 33 partial partial JJ cord-010119-t1x9gknd 7472 34 D d NN cord-010119-t1x9gknd 7472 35 and and CC cord-010119-t1x9gknd 7472 36 negative negative JJ cord-010119-t1x9gknd 7472 37 phenotypes phenotype NNS cord-010119-t1x9gknd 7472 38 are be VBP cord-010119-t1x9gknd 7472 39 . . . cord-010119-t1x9gknd 7473 1 Routine routine JJ cord-010119-t1x9gknd 7473 2 serologic serologic NN cord-010119-t1x9gknd 7473 3 D d NN cord-010119-t1x9gknd 7473 4 typing typing NN cord-010119-t1x9gknd 7473 5 does do VBZ cord-010119-t1x9gknd 7473 6 not not RB cord-010119-t1x9gknd 7473 7 distinguish distinguish VB cord-010119-t1x9gknd 7473 8 among among IN cord-010119-t1x9gknd 7473 9 them -PRON- PRP cord-010119-t1x9gknd 7473 10 , , , cord-010119-t1x9gknd 7473 11 consequently consequently RB cord-010119-t1x9gknd 7473 12 RHD RHD NNP cord-010119-t1x9gknd 7473 13 genotyping genotyping NN cord-010119-t1x9gknd 7473 14 is be VBZ cord-010119-t1x9gknd 7473 15 recommended recommend VBN cord-010119-t1x9gknd 7473 16 , , , cord-010119-t1x9gknd 7473 17 especially especially RB cord-010119-t1x9gknd 7473 18 in in IN cord-010119-t1x9gknd 7473 19 patients patient NNS cord-010119-t1x9gknd 7473 20 . . . cord-010119-t1x9gknd 7474 1 ID ID NNP cord-010119-t1x9gknd 7474 2 RHD RHD NNP cord-010119-t1x9gknd 7474 3 XT XT NNP cord-010119-t1x9gknd 7474 4 ( ( -LRB- cord-010119-t1x9gknd 7474 5 Progenika Progenika NNP cord-010119-t1x9gknd 7474 6 , , , cord-010119-t1x9gknd 7474 7 Grifols Grifols NNP cord-010119-t1x9gknd 7474 8 ) ) -RRB- cord-010119-t1x9gknd 7474 9 is be VBZ cord-010119-t1x9gknd 7474 10 a a DT cord-010119-t1x9gknd 7474 11 qualitative qualitative JJ cord-010119-t1x9gknd 7474 12 , , , cord-010119-t1x9gknd 7474 13 PCR PCR NNP cord-010119-t1x9gknd 7474 14 / / SYM cord-010119-t1x9gknd 7474 15 Luminex Luminex NNP cord-010119-t1x9gknd 7474 16 V V NNP cord-010119-t1x9gknd 7474 17 R r NN cord-010119-t1x9gknd 7474 18 xMAP xmap NN cord-010119-t1x9gknd 7474 19 hybridization hybridization NN cord-010119-t1x9gknd 7474 20 - - HYPH cord-010119-t1x9gknd 7474 21 based base VBN cord-010119-t1x9gknd 7474 22 genotyping genotyping NN cord-010119-t1x9gknd 7474 23 test test NN cord-010119-t1x9gknd 7474 24 for for IN cord-010119-t1x9gknd 7474 25 the the DT cord-010119-t1x9gknd 7474 26 identification identification NN cord-010119-t1x9gknd 7474 27 of of IN cord-010119-t1x9gknd 7474 28 the the DT cord-010119-t1x9gknd 7474 29 following following JJ cord-010119-t1x9gknd 7474 30 RHD RHD NNP cord-010119-t1x9gknd 7474 31 gene gene NN cord-010119-t1x9gknd 7474 32 allelic allelic JJ cord-010119-t1x9gknd 7474 33 variants variant NNS cord-010119-t1x9gknd 7474 34 : : : cord-010119-t1x9gknd 7475 1 RHD*weak RHD*weak NNP cord-010119-t1x9gknd 7475 2 D D NNP cord-010119-t1x9gknd 7475 3 type type NN cord-010119-t1x9gknd 7475 4 1 1 CD cord-010119-t1x9gknd 7475 5 , , , cord-010119-t1x9gknd 7475 6 RHD*weak RHD*weak NNP cord-010119-t1x9gknd 7475 7 D D NNP cord-010119-t1x9gknd 7475 8 type type NN cord-010119-t1x9gknd 7475 9 2 2 CD cord-010119-t1x9gknd 7475 10 , , , cord-010119-t1x9gknd 7475 11 RHD*weak RHD*weak NNP cord-010119-t1x9gknd 7475 12 D D NNP cord-010119-t1x9gknd 7475 13 type type NN cord-010119-t1x9gknd 7475 14 3 3 CD cord-010119-t1x9gknd 7475 15 , , , cord-010119-t1x9gknd 7475 16 RHD RHD NNP cord-010119-t1x9gknd 7475 17 deletion deletion NN cord-010119-t1x9gknd 7475 18 , , , cord-010119-t1x9gknd 7475 19 RHD*Pseudogene rhd*pseudogene JJ cord-010119-t1x9gknd 7475 20 and and CC cord-010119-t1x9gknd 7475 21 RHD*DIIIa RHD*DIIIa NNP cord-010119-t1x9gknd 7475 22 - - HYPH cord-010119-t1x9gknd 7475 23 CE(3 CE(3 NNP cord-010119-t1x9gknd 7475 24 - - HYPH cord-010119-t1x9gknd 7475 25 7)-D 7)-d NN cord-010119-t1x9gknd 7475 26 and and CC cord-010119-t1x9gknd 7475 27 ITGB3 itgb3 JJ cord-010119-t1x9gknd 7475 28 gene gene NN cord-010119-t1x9gknd 7475 29 : : : cord-010119-t1x9gknd 7476 1 HPA1a HPA1a NNP cord-010119-t1x9gknd 7476 2 and and CC cord-010119-t1x9gknd 7476 3 HPA1b HPA1b NNP cord-010119-t1x9gknd 7476 4 , , , cord-010119-t1x9gknd 7476 5 in in IN cord-010119-t1x9gknd 7476 6 genomic genomic JJ cord-010119-t1x9gknd 7476 7 DNA dna NN cord-010119-t1x9gknd 7476 8 extracted extract VBN cord-010119-t1x9gknd 7476 9 from from IN cord-010119-t1x9gknd 7476 10 whole whole JJ cord-010119-t1x9gknd 7476 11 blood blood NN cord-010119-t1x9gknd 7476 12 specimens specimen NNS cord-010119-t1x9gknd 7476 13 . . . cord-010119-t1x9gknd 7477 1 In in IN cord-010119-t1x9gknd 7477 2 this this DT cord-010119-t1x9gknd 7477 3 study study NN cord-010119-t1x9gknd 7477 4 the the DT cord-010119-t1x9gknd 7477 5 performance performance NN cord-010119-t1x9gknd 7477 6 of of IN cord-010119-t1x9gknd 7477 7 ID ID NNP cord-010119-t1x9gknd 7477 8 RHD RHD NNP cord-010119-t1x9gknd 7477 9 XT XT NNP cord-010119-t1x9gknd 7477 10 genotyping genotyping NN cord-010119-t1x9gknd 7477 11 assay assay NN cord-010119-t1x9gknd 7477 12 was be VBD cord-010119-t1x9gknd 7477 13 evaluated evaluate VBN cord-010119-t1x9gknd 7477 14 in in IN cord-010119-t1x9gknd 7477 15 terms term NNS cord-010119-t1x9gknd 7477 16 of of IN cord-010119-t1x9gknd 7477 17 whole whole JJ cord-010119-t1x9gknd 7477 18 system system NN cord-010119-t1x9gknd 7477 19 failure failure NN cord-010119-t1x9gknd 7477 20 rate rate NN cord-010119-t1x9gknd 7477 21 , , , cord-010119-t1x9gknd 7477 22 call call NN cord-010119-t1x9gknd 7477 23 rate rate NN cord-010119-t1x9gknd 7477 24 and and CC cord-010119-t1x9gknd 7477 25 accuracy accuracy NN cord-010119-t1x9gknd 7477 26 for for IN cord-010119-t1x9gknd 7477 27 Rh Rh NNP cord-010119-t1x9gknd 7477 28 and and CC cord-010119-t1x9gknd 7477 29 HPA-1 HPA-1 NNP cord-010119-t1x9gknd 7477 30 blood blood NN cord-010119-t1x9gknd 7477 31 group group NN cord-010119-t1x9gknd 7477 32 typing typing NN cord-010119-t1x9gknd 7477 33 . . . cord-010119-t1x9gknd 7478 1 Study Study NNP cord-010119-t1x9gknd 7478 2 Design Design NNP cord-010119-t1x9gknd 7478 3 / / SYM cord-010119-t1x9gknd 7478 4 Method method NN cord-010119-t1x9gknd 7478 5 : : : cord-010119-t1x9gknd 7479 1 A a DT cord-010119-t1x9gknd 7479 2 cohort cohort NN cord-010119-t1x9gknd 7479 3 of of IN cord-010119-t1x9gknd 7479 4 1000 1000 CD cord-010119-t1x9gknd 7479 5 previously previously RB cord-010119-t1x9gknd 7479 6 serotyped serotyped JJ cord-010119-t1x9gknd 7479 7 samples sample NNS cord-010119-t1x9gknd 7479 8 for for IN cord-010119-t1x9gknd 7479 9 D D NNP cord-010119-t1x9gknd 7479 10 antigen antigen NN cord-010119-t1x9gknd 7479 11 obtained obtain VBN cord-010119-t1x9gknd 7479 12 from from IN cord-010119-t1x9gknd 7479 13 three three CD cord-010119-t1x9gknd 7479 14 European european JJ cord-010119-t1x9gknd 7479 15 blood blood NN cord-010119-t1x9gknd 7479 16 centers center NNS cord-010119-t1x9gknd 7479 17 were be VBD cord-010119-t1x9gknd 7479 18 analyzed analyze VBN cord-010119-t1x9gknd 7479 19 with with IN cord-010119-t1x9gknd 7479 20 ID ID NNP cord-010119-t1x9gknd 7479 21 RHD RHD NNP cord-010119-t1x9gknd 7479 22 XT XT NNP cord-010119-t1x9gknd 7479 23 at at IN cord-010119-t1x9gknd 7479 24 Progenika Progenika NNP cord-010119-t1x9gknd 7479 25 . . . cord-010119-t1x9gknd 7480 1 Samples sample NNS cord-010119-t1x9gknd 7480 2 were be VBD cord-010119-t1x9gknd 7480 3 distributed distribute VBN cord-010119-t1x9gknd 7480 4 as as IN cord-010119-t1x9gknd 7480 5 recommended recommend VBN cord-010119-t1x9gknd 7480 6 by by IN cord-010119-t1x9gknd 7480 7 the the DT cord-010119-t1x9gknd 7480 8 Annex Annex NNP cord-010119-t1x9gknd 7480 9 of of IN cord-010119-t1x9gknd 7480 10 the the DT cord-010119-t1x9gknd 7480 11 Common Common NNP cord-010119-t1x9gknd 7480 12 Technical Technical NNP cord-010119-t1x9gknd 7480 13 Specifications Specifications NNPS cord-010119-t1x9gknd 7480 14 2009/108 2009/108 CD cord-010119-t1x9gknd 7480 15 / / SYM cord-010119-t1x9gknd 7480 16 CE ce NN cord-010119-t1x9gknd 7480 17 for for IN cord-010119-t1x9gknd 7480 18 a a DT cord-010119-t1x9gknd 7480 19 IVD IVD NNP cord-010119-t1x9gknd 7480 20 product product NN cord-010119-t1x9gknd 7480 21 of of IN cord-010119-t1x9gknd 7480 22 list list NN cord-010119-t1x9gknd 7480 23 A a NN cord-010119-t1x9gknd 7480 24 ( ( -LRB- cord-010119-t1x9gknd 7480 25 ! ! . cord-010119-t1x9gknd 7480 26 10 10 CD cord-010119-t1x9gknd 7480 27 % % NN cord-010119-t1x9gknd 7480 28 Clinical clinical JJ cord-010119-t1x9gknd 7480 29 samples sample NNS cord-010119-t1x9gknd 7480 30 , , , cord-010119-t1x9gknd 7480 31 > > SYM cord-010119-t1x9gknd 7480 32 2 2 CD cord-010119-t1x9gknd 7480 33 % % NN cord-010119-t1x9gknd 7480 34 Neonatal neonatal JJ cord-010119-t1x9gknd 7480 35 Specimens Specimens NNPS cord-010119-t1x9gknd 7480 36 and and CC cord-010119-t1x9gknd 7480 37 ! ! . cord-010119-t1x9gknd 7480 38 2 2 CD cord-010119-t1x9gknd 7480 39 % % NN cord-010119-t1x9gknd 7480 40 Weak weak JJ cord-010119-t1x9gknd 7480 41 D D NNP cord-010119-t1x9gknd 7480 42 donors donor NNS cord-010119-t1x9gknd 7480 43 ) ) -RRB- cord-010119-t1x9gknd 7480 44 . . . cord-010119-t1x9gknd 7481 1 For for IN cord-010119-t1x9gknd 7481 2 the the DT cord-010119-t1x9gknd 7481 3 intended intend VBN cord-010119-t1x9gknd 7481 4 use use NN cord-010119-t1x9gknd 7481 5 of of IN cord-010119-t1x9gknd 7481 6 the the DT cord-010119-t1x9gknd 7481 7 product product NN cord-010119-t1x9gknd 7481 8 , , , cord-010119-t1x9gknd 7481 9 Weak Weak NNP cord-010119-t1x9gknd 7481 10 D D NNP cord-010119-t1x9gknd 7481 11 serotyped serotyped JJ cord-010119-t1x9gknd 7481 12 donors donor NNS cord-010119-t1x9gknd 7481 13 were be VBD cord-010119-t1x9gknd 7481 14 enriched enrich VBN cord-010119-t1x9gknd 7481 15 ( ( -LRB- cord-010119-t1x9gknd 7481 16 n5160 n5160 NN cord-010119-t1x9gknd 7481 17 , , , cord-010119-t1x9gknd 7481 18 16 16 CD cord-010119-t1x9gknd 7481 19 % % NN cord-010119-t1x9gknd 7481 20 ) ) -RRB- cord-010119-t1x9gknd 7481 21 . . . cord-010119-t1x9gknd 7482 1 Commercial commercial JJ cord-010119-t1x9gknd 7482 2 serology serology NN cord-010119-t1x9gknd 7482 3 tests test VBZ cord-010119-t1x9gknd 7482 4 for for IN cord-010119-t1x9gknd 7482 5 D D NNP cord-010119-t1x9gknd 7482 6 antigen antigen NN cord-010119-t1x9gknd 7482 7 predicted predict VBD cord-010119-t1x9gknd 7482 8 phenotype phenotype NN cord-010119-t1x9gknd 7482 9 and and CC cord-010119-t1x9gknd 7482 10 Bi Bi NNP cord-010119-t1x9gknd 7482 11 - - HYPH cord-010119-t1x9gknd 7482 12 Directional Directional NNP cord-010119-t1x9gknd 7482 13 - - HYPH cord-010119-t1x9gknd 7482 14 Sequencing Sequencing NNP cord-010119-t1x9gknd 7482 15 ( ( -LRB- cord-010119-t1x9gknd 7482 16 BDS BDS NNP cord-010119-t1x9gknd 7482 17 ) ) -RRB- cord-010119-t1x9gknd 7482 18 for for IN cord-010119-t1x9gknd 7482 19 weak weak JJ cord-010119-t1x9gknd 7482 20 D D NNP cord-010119-t1x9gknd 7482 21 type type NN cord-010119-t1x9gknd 7482 22 confirmation confirmation NN cord-010119-t1x9gknd 7482 23 and and CC cord-010119-t1x9gknd 7483 1 HPA-1 HPA-1 NNP cord-010119-t1x9gknd 7483 2 predicted predict VBD cord-010119-t1x9gknd 7483 3 phenotype phenotype NN cord-010119-t1x9gknd 7483 4 were be VBD cord-010119-t1x9gknd 7483 5 used use VBN cord-010119-t1x9gknd 7483 6 for for IN cord-010119-t1x9gknd 7483 7 comparison comparison NN cord-010119-t1x9gknd 7483 8 . . . cord-010119-t1x9gknd 7484 1 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 7484 2 Results result NNS cord-010119-t1x9gknd 7484 3 / / SYM cord-010119-t1x9gknd 7484 4 Finding finding NN cord-010119-t1x9gknd 7484 5 : : : cord-010119-t1x9gknd 7484 6 No no DT cord-010119-t1x9gknd 7484 7 system system NN cord-010119-t1x9gknd 7484 8 failure failure NN cord-010119-t1x9gknd 7484 9 , , , cord-010119-t1x9gknd 7484 10 100 100 CD cord-010119-t1x9gknd 7484 11 % % NN cord-010119-t1x9gknd 7484 12 call call NN cord-010119-t1x9gknd 7484 13 rate rate NN cord-010119-t1x9gknd 7484 14 and and CC cord-010119-t1x9gknd 7484 15 no no DT cord-010119-t1x9gknd 7484 16 inconclusive inconclusive JJ cord-010119-t1x9gknd 7484 17 results result NNS cord-010119-t1x9gknd 7484 18 were be VBD cord-010119-t1x9gknd 7484 19 obtained obtain VBN cord-010119-t1x9gknd 7484 20 . . . cord-010119-t1x9gknd 7485 1 Discrepancies discrepancy NNS cord-010119-t1x9gknd 7485 2 were be VBD cord-010119-t1x9gknd 7485 3 found find VBN cord-010119-t1x9gknd 7485 4 for for IN cord-010119-t1x9gknd 7485 5 D d NN cord-010119-t1x9gknd 7485 6 antigen antigen NN cord-010119-t1x9gknd 7485 7 between between IN cord-010119-t1x9gknd 7485 8 serology serology NN cord-010119-t1x9gknd 7485 9 and and CC cord-010119-t1x9gknd 7485 10 ID ID NNP cord-010119-t1x9gknd 7485 11 RHD RHD NNP cord-010119-t1x9gknd 7485 12 XT XT NNP cord-010119-t1x9gknd 7485 13 predicted predict VBD cord-010119-t1x9gknd 7485 14 phenotype phenotype NN cord-010119-t1x9gknd 7485 15 results result NNS cord-010119-t1x9gknd 7485 16 , , , cord-010119-t1x9gknd 7485 17 although although IN cord-010119-t1x9gknd 7485 18 a a DT cord-010119-t1x9gknd 7485 19 100 100 CD cord-010119-t1x9gknd 7485 20 % % NN cord-010119-t1x9gknd 7485 21 concordance concordance NN cord-010119-t1x9gknd 7485 22 was be VBD cord-010119-t1x9gknd 7485 23 obtained obtain VBN cord-010119-t1x9gknd 7485 24 when when WRB cord-010119-t1x9gknd 7485 25 analyzed analyze VBN cord-010119-t1x9gknd 7485 26 by by IN cord-010119-t1x9gknd 7485 27 BDS BDS NNP cord-010119-t1x9gknd 7485 28 , , , cord-010119-t1x9gknd 7485 29 considering consider VBG cord-010119-t1x9gknd 7485 30 ID ID NNP cord-010119-t1x9gknd 7485 31 RHD RHD NNP cord-010119-t1x9gknd 7485 32 XT XT NNP cord-010119-t1x9gknd 7485 33 result result NN cord-010119-t1x9gknd 7485 34 correct correct JJ cord-010119-t1x9gknd 7485 35 . . . cord-010119-t1x9gknd 7486 1 Concordance concordance NN cord-010119-t1x9gknd 7486 2 between between IN cord-010119-t1x9gknd 7486 3 ID ID NNP cord-010119-t1x9gknd 7486 4 RHD RHD NNP cord-010119-t1x9gknd 7486 5 XT XT NNP cord-010119-t1x9gknd 7486 6 and and CC cord-010119-t1x9gknd 7486 7 BDS BDS NNP cord-010119-t1x9gknd 7486 8 results result VBZ cord-010119-t1x9gknd 7486 9 for for IN cord-010119-t1x9gknd 7486 10 the the DT cord-010119-t1x9gknd 7486 11 Weak Weak NNP cord-010119-t1x9gknd 7486 12 D D NNP cord-010119-t1x9gknd 7486 13 type type NN cord-010119-t1x9gknd 7486 14 was be VBD cord-010119-t1x9gknd 7486 15 100 100 CD cord-010119-t1x9gknd 7486 16 % % NN cord-010119-t1x9gknd 7486 17 . . . cord-010119-t1x9gknd 7487 1 The the DT cord-010119-t1x9gknd 7487 2 following follow VBG cord-010119-t1x9gknd 7487 3 ID ID NNP cord-010119-t1x9gknd 7487 4 RHD RHD NNP cord-010119-t1x9gknd 7487 5 XT XT NNP cord-010119-t1x9gknd 7487 6 predicted predict VBD cord-010119-t1x9gknd 7487 7 phenotype phenotype NN cord-010119-t1x9gknd 7487 8 results result NNS cord-010119-t1x9gknd 7487 9 were be VBD cord-010119-t1x9gknd 7487 10 obtained obtain VBN cord-010119-t1x9gknd 7487 11 : : : cord-010119-t1x9gknd 7487 12 D d JJ cord-010119-t1x9gknd 7487 13 negative negative JJ cord-010119-t1x9gknd 7487 14 ( ( -LRB- cord-010119-t1x9gknd 7487 15 n5361 n5361 NNP cord-010119-t1x9gknd 7487 16 ) ) -RRB- cord-010119-t1x9gknd 7487 17 , , , cord-010119-t1x9gknd 7487 18 No no DT cord-010119-t1x9gknd 7487 19 amplification amplification NN cord-010119-t1x9gknd 7487 20 variant variant NN cord-010119-t1x9gknd 7487 21 ( ( -LRB- cord-010119-t1x9gknd 7487 22 n515 n515 NNS cord-010119-t1x9gknd 7487 23 ) ) -RRB- cord-010119-t1x9gknd 7487 24 , , , cord-010119-t1x9gknd 7487 25 Weak Weak NNP cord-010119-t1x9gknd 7487 26 D D NNP cord-010119-t1x9gknd 7487 27 Type type NN cord-010119-t1x9gknd 7487 28 1 1 CD cord-010119-t1x9gknd 7487 29 ( ( -LRB- cord-010119-t1x9gknd 7487 30 n522 n522 NNP cord-010119-t1x9gknd 7487 31 ) ) -RRB- cord-010119-t1x9gknd 7487 32 , , . cord-010119-t1x9gknd 7488 1 Weak weak JJ cord-010119-t1x9gknd 7488 2 D d NN cord-010119-t1x9gknd 7488 3 Type type NN cord-010119-t1x9gknd 7488 4 1 1 CD cord-010119-t1x9gknd 7488 5 heterozygous heterozygous JJ cord-010119-t1x9gknd 7488 6 ( ( -LRB- cord-010119-t1x9gknd 7488 7 n51 n51 NNP cord-010119-t1x9gknd 7488 8 ) ) -RRB- cord-010119-t1x9gknd 7488 9 , , , cord-010119-t1x9gknd 7488 10 Weak Weak NNP cord-010119-t1x9gknd 7488 11 D d NN cord-010119-t1x9gknd 7488 12 Type type NN cord-010119-t1x9gknd 7488 13 2 2 CD cord-010119-t1x9gknd 7488 14 ( ( -LRB- cord-010119-t1x9gknd 7488 15 n532 n532 NNP cord-010119-t1x9gknd 7488 16 ) ) -RRB- cord-010119-t1x9gknd 7488 17 , , . cord-010119-t1x9gknd 7489 1 Weak weak JJ cord-010119-t1x9gknd 7489 2 D d NN cord-010119-t1x9gknd 7489 3 Type type NN cord-010119-t1x9gknd 7489 4 2 2 CD cord-010119-t1x9gknd 7489 5 heterozygous heterozygous JJ cord-010119-t1x9gknd 7489 6 ( ( -LRB- cord-010119-t1x9gknd 7489 7 n51 n51 '' cord-010119-t1x9gknd 7489 8 ) ) -RRB- cord-010119-t1x9gknd 7489 9 , , , cord-010119-t1x9gknd 7489 10 Weak Weak NNP cord-010119-t1x9gknd 7489 11 D D NNP cord-010119-t1x9gknd 7489 12 Type type NN cord-010119-t1x9gknd 7489 13 3 3 CD cord-010119-t1x9gknd 7489 14 ( ( -LRB- cord-010119-t1x9gknd 7489 15 n534 n534 NNP cord-010119-t1x9gknd 7489 16 ) ) -RRB- cord-010119-t1x9gknd 7489 17 , , , cord-010119-t1x9gknd 7489 18 Weak Weak NNP cord-010119-t1x9gknd 7489 19 D D NNP cord-010119-t1x9gknd 7489 20 Type type NN cord-010119-t1x9gknd 7489 21 3 3 CD cord-010119-t1x9gknd 7490 1 heterozygous heterozygous JJ cord-010119-t1x9gknd 7490 2 ( ( -LRB- cord-010119-t1x9gknd 7490 3 n51 n51 NNP cord-010119-t1x9gknd 7490 4 ) ) -RRB- cord-010119-t1x9gknd 7490 5 , , . cord-010119-t1x9gknd 7491 1 Weak weak JJ cord-010119-t1x9gknd 7491 2 D D NNP cord-010119-t1x9gknd 7491 3 Types type NNS cord-010119-t1x9gknd 7491 4 1 1 CD cord-010119-t1x9gknd 7491 5 , , , cord-010119-t1x9gknd 7491 6 2 2 CD cord-010119-t1x9gknd 7491 7 or or CC cord-010119-t1x9gknd 7491 8 3 3 CD cord-010119-t1x9gknd 7491 9 not not RB cord-010119-t1x9gknd 7491 10 detected detect VBN cord-010119-t1x9gknd 7491 11 ( ( -LRB- cord-010119-t1x9gknd 7491 12 n5533 n5533 NNP cord-010119-t1x9gknd 7491 13 ) ) -RRB- cord-010119-t1x9gknd 7491 14 . . . cord-010119-t1x9gknd 7492 1 Regarding regard VBG cord-010119-t1x9gknd 7492 2 HPA-1 HPA-1 NNP cord-010119-t1x9gknd 7492 3 blood blood NN cord-010119-t1x9gknd 7492 4 group group NN cord-010119-t1x9gknd 7492 5 , , , cord-010119-t1x9gknd 7492 6 the the DT cord-010119-t1x9gknd 7492 7 predicted predict VBN cord-010119-t1x9gknd 7492 8 phenotype phenotype NN cord-010119-t1x9gknd 7492 9 results result NNS cord-010119-t1x9gknd 7492 10 obtained obtain VBN cord-010119-t1x9gknd 7492 11 by by IN cord-010119-t1x9gknd 7492 12 ID ID NNP cord-010119-t1x9gknd 7492 13 RHD RHD NNP cord-010119-t1x9gknd 7492 14 XT XT NNP cord-010119-t1x9gknd 7492 15 were be VBD cord-010119-t1x9gknd 7492 16 100 100 CD cord-010119-t1x9gknd 7492 17 % % NN cord-010119-t1x9gknd 7492 18 concordant concordant JJ cord-010119-t1x9gknd 7492 19 with with IN cord-010119-t1x9gknd 7492 20 BDS BDS NNP cord-010119-t1x9gknd 7492 21 results result NNS cord-010119-t1x9gknd 7492 22 : : : cord-010119-t1x9gknd 7492 23 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 7492 24 positive positive JJ cord-010119-t1x9gknd 7492 25 ( ( -LRB- cord-010119-t1x9gknd 7492 26 n5157 n5157 NNP cord-010119-t1x9gknd 7492 27 ) ) -RRB- cord-010119-t1x9gknd 7492 28 and and CC cord-010119-t1x9gknd 7492 29 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 7492 30 negative negative JJ cord-010119-t1x9gknd 7492 31 ( ( -LRB- cord-010119-t1x9gknd 7492 32 n56 n56 NN cord-010119-t1x9gknd 7492 33 ) ) -RRB- cord-010119-t1x9gknd 7492 34 , , . cord-010119-t1x9gknd 7493 1 HPA-1b HPA-1b NNP cord-010119-t1x9gknd 7493 2 positive positive JJ cord-010119-t1x9gknd 7493 3 ( ( -LRB- cord-010119-t1x9gknd 7493 4 n546 n546 NN cord-010119-t1x9gknd 7493 5 ) ) -RRB- cord-010119-t1x9gknd 7493 6 and and CC cord-010119-t1x9gknd 7494 1 HPA-1b HPA-1b NNP cord-010119-t1x9gknd 7494 2 negative negative JJ cord-010119-t1x9gknd 7494 3 ( ( -LRB- cord-010119-t1x9gknd 7494 4 n5117 n5117 NNP cord-010119-t1x9gknd 7494 5 ) ) -RRB- cord-010119-t1x9gknd 7494 6 . . . cord-010119-t1x9gknd 7495 1 Conclusion conclusion NN cord-010119-t1x9gknd 7495 2 : : : cord-010119-t1x9gknd 7495 3 ID ID NNP cord-010119-t1x9gknd 7495 4 RHD RHD NNP cord-010119-t1x9gknd 7495 5 XT XT NNP cord-010119-t1x9gknd 7495 6 genotyping genotyping NN cord-010119-t1x9gknd 7495 7 assay assay NN cord-010119-t1x9gknd 7495 8 performed perform VBN cord-010119-t1x9gknd 7495 9 as as IN cord-010119-t1x9gknd 7495 10 a a DT cord-010119-t1x9gknd 7495 11 reliable reliable JJ cord-010119-t1x9gknd 7495 12 and and CC cord-010119-t1x9gknd 7495 13 accurate accurate JJ cord-010119-t1x9gknd 7495 14 method method NN cord-010119-t1x9gknd 7495 15 for for IN cord-010119-t1x9gknd 7495 16 predicting predict VBG cord-010119-t1x9gknd 7495 17 the the DT cord-010119-t1x9gknd 7495 18 genotype genotype NN cord-010119-t1x9gknd 7495 19 and and CC cord-010119-t1x9gknd 7495 20 phenotype phenotype NN cord-010119-t1x9gknd 7495 21 of of IN cord-010119-t1x9gknd 7495 22 high high JJ cord-010119-t1x9gknd 7495 23 prevalence prevalence NN cord-010119-t1x9gknd 7495 24 RHD rhd NN cord-010119-t1x9gknd 7495 25 negative negative JJ cord-010119-t1x9gknd 7495 26 and and CC cord-010119-t1x9gknd 7495 27 Weak weak JJ cord-010119-t1x9gknd 7495 28 D d NN cord-010119-t1x9gknd 7495 29 types type NNS cord-010119-t1x9gknd 7495 30 ( ( -LRB- cord-010119-t1x9gknd 7495 31 100 100 CD cord-010119-t1x9gknd 7495 32 % % NN cord-010119-t1x9gknd 7495 33 specificity specificity NN cord-010119-t1x9gknd 7495 34 and and CC cord-010119-t1x9gknd 7495 35 100 100 CD cord-010119-t1x9gknd 7495 36 % % NN cord-010119-t1x9gknd 7495 37 sensitivity sensitivity NN cord-010119-t1x9gknd 7495 38 for for IN cord-010119-t1x9gknd 7495 39 D D NNP cord-010119-t1x9gknd 7495 40 antigen antigen NN cord-010119-t1x9gknd 7495 41 , , , cord-010119-t1x9gknd 7495 42 HPA-1a HPA-1a NNP cord-010119-t1x9gknd 7495 43 and and CC cord-010119-t1x9gknd 7495 44 HPA-1b HPA-1b NNP cord-010119-t1x9gknd 7495 45 antigens antigen NNS cord-010119-t1x9gknd 7495 46 ) ) -RRB- cord-010119-t1x9gknd 7495 47 . . . cord-010119-t1x9gknd 7496 1 That that DT cord-010119-t1x9gknd 7496 2 makes make VBZ cord-010119-t1x9gknd 7496 3 it -PRON- PRP cord-010119-t1x9gknd 7496 4 a a DT cord-010119-t1x9gknd 7496 5 useful useful JJ cord-010119-t1x9gknd 7496 6 tool tool NN cord-010119-t1x9gknd 7496 7 for for IN cord-010119-t1x9gknd 7496 8 the the DT cord-010119-t1x9gknd 7496 9 implementation implementation NN cord-010119-t1x9gknd 7496 10 of of IN cord-010119-t1x9gknd 7496 11 the the DT cord-010119-t1x9gknd 7496 12 RHDgenotyping rhdgenotyping NN cord-010119-t1x9gknd 7496 13 recommendation recommendation NN cord-010119-t1x9gknd 7496 14 on on IN cord-010119-t1x9gknd 7496 15 patient patient JJ cord-010119-t1x9gknd 7496 16 blood blood NN cord-010119-t1x9gknd 7496 17 transfusion transfusion NN cord-010119-t1x9gknd 7496 18 and and CC cord-010119-t1x9gknd 7496 19 anti anti JJ cord-010119-t1x9gknd 7496 20 - - JJ cord-010119-t1x9gknd 7496 21 D d JJ cord-010119-t1x9gknd 7496 22 prophylaxis prophylaxis NN cord-010119-t1x9gknd 7496 23 . . . cord-010119-t1x9gknd 7496 24 _SP cord-010119-t1x9gknd 7497 1 Background Background NNP cord-010119-t1x9gknd 7497 2 / / SYM cord-010119-t1x9gknd 7497 3 Case Case NNP cord-010119-t1x9gknd 7497 4 Studies Studies NNPS cord-010119-t1x9gknd 7497 5 : : : cord-010119-t1x9gknd 7497 6 SCD SCD NNP cord-010119-t1x9gknd 7497 7 patients patient NNS cord-010119-t1x9gknd 7497 8 form form VBP cord-010119-t1x9gknd 7497 9 red red JJ cord-010119-t1x9gknd 7497 10 blood blood NN cord-010119-t1x9gknd 7497 11 cell cell NN cord-010119-t1x9gknd 7497 12 ( ( -LRB- cord-010119-t1x9gknd 7497 13 RBC RBC NNP cord-010119-t1x9gknd 7497 14 ) ) -RRB- cord-010119-t1x9gknd 7497 15 antibodies antibody NNS cord-010119-t1x9gknd 7497 16 at at IN cord-010119-t1x9gknd 7497 17 higher high JJR cord-010119-t1x9gknd 7497 18 rates rate NNS cord-010119-t1x9gknd 7497 19 than than IN cord-010119-t1x9gknd 7497 20 other other JJ cord-010119-t1x9gknd 7497 21 transfused transfuse VBN cord-010119-t1x9gknd 7497 22 populations population NNS cord-010119-t1x9gknd 7497 23 . . . cord-010119-t1x9gknd 7498 1 Multiple multiple JJ cord-010119-t1x9gknd 7498 2 predictors predictor NNS cord-010119-t1x9gknd 7498 3 of of IN cord-010119-t1x9gknd 7498 4 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7498 5 have have VBP cord-010119-t1x9gknd 7498 6 been be VBN cord-010119-t1x9gknd 7498 7 reported report VBN cord-010119-t1x9gknd 7498 8 but but CC cord-010119-t1x9gknd 7498 9 not not RB cord-010119-t1x9gknd 7498 10 well well RB cord-010119-t1x9gknd 7498 11 replicated replicate VBN cord-010119-t1x9gknd 7498 12 in in IN cord-010119-t1x9gknd 7498 13 large large JJ cord-010119-t1x9gknd 7498 14 SCD SCD NNP cord-010119-t1x9gknd 7498 15 cohorts cohort NNS cord-010119-t1x9gknd 7498 16 . . . cord-010119-t1x9gknd 7499 1 We -PRON- PRP cord-010119-t1x9gknd 7499 2 investigated investigate VBD cord-010119-t1x9gknd 7499 3 the the DT cord-010119-t1x9gknd 7499 4 clinical clinical JJ cord-010119-t1x9gknd 7499 5 , , , cord-010119-t1x9gknd 7499 6 laboratory laboratory NN cord-010119-t1x9gknd 7499 7 and and CC cord-010119-t1x9gknd 7499 8 genetic genetic JJ cord-010119-t1x9gknd 7499 9 predictors predictor NNS cord-010119-t1x9gknd 7499 10 of of IN cord-010119-t1x9gknd 7499 11 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7499 12 . . . cord-010119-t1x9gknd 7500 1 Study Study NNP cord-010119-t1x9gknd 7500 2 Design Design NNP cord-010119-t1x9gknd 7500 3 / / SYM cord-010119-t1x9gknd 7500 4 Method method NN cord-010119-t1x9gknd 7500 5 : : : cord-010119-t1x9gknd 7500 6 A a DT cord-010119-t1x9gknd 7500 7 large large JJ cord-010119-t1x9gknd 7500 8 SCD SCD NNP cord-010119-t1x9gknd 7500 9 cohort cohort NN cord-010119-t1x9gknd 7500 10 was be VBD cord-010119-t1x9gknd 7500 11 established establish VBN cord-010119-t1x9gknd 7500 12 in in IN cord-010119-t1x9gknd 7500 13 Brazil Brazil NNP cord-010119-t1x9gknd 7500 14 to to TO cord-010119-t1x9gknd 7500 15 investigate investigate VB cord-010119-t1x9gknd 7500 16 disease disease NN cord-010119-t1x9gknd 7500 17 outcomes outcome NNS cord-010119-t1x9gknd 7500 18 . . . cord-010119-t1x9gknd 7501 1 At at IN cord-010119-t1x9gknd 7501 2 participating participate VBG cord-010119-t1x9gknd 7501 3 sites site NNS cord-010119-t1x9gknd 7501 4 , , , cord-010119-t1x9gknd 7501 5 patients patient NNS cord-010119-t1x9gknd 7501 6 are be VBP cord-010119-t1x9gknd 7501 7 currently currently RB cord-010119-t1x9gknd 7501 8 transfused transfuse VBN cord-010119-t1x9gknd 7501 9 with with IN cord-010119-t1x9gknd 7501 10 ABO ABO NNP cord-010119-t1x9gknd 7501 11 / / SYM cord-010119-t1x9gknd 7501 12 D D NNP cord-010119-t1x9gknd 7501 13 / / SYM cord-010119-t1x9gknd 7501 14 Cc Cc NNP cord-010119-t1x9gknd 7501 15 / / SYM cord-010119-t1x9gknd 7501 16 Ee Ee NNP cord-010119-t1x9gknd 7501 17 / / SYM cord-010119-t1x9gknd 7501 18 Kell Kell NNP cord-010119-t1x9gknd 7501 19 matched match VBD cord-010119-t1x9gknd 7501 20 RBCs rbc NNS cord-010119-t1x9gknd 7501 21 prophylactically prophylactically RB cord-010119-t1x9gknd 7501 22 and and CC cord-010119-t1x9gknd 7501 23 extended extend VBD cord-010119-t1x9gknd 7501 24 phenotypically phenotypically RB cord-010119-t1x9gknd 7501 25 matched match VBN cord-010119-t1x9gknd 7501 26 RBC RBC NNP cord-010119-t1x9gknd 7501 27 after after IN cord-010119-t1x9gknd 7501 28 first first JJ cord-010119-t1x9gknd 7501 29 antibody antibody NN cord-010119-t1x9gknd 7501 30 forms form NNS cord-010119-t1x9gknd 7501 31 . . . cord-010119-t1x9gknd 7502 1 Policies policy NNS cord-010119-t1x9gknd 7502 2 for for IN cord-010119-t1x9gknd 7502 3 matching match VBG cord-010119-t1x9gknd 7502 4 are be VBP cord-010119-t1x9gknd 7502 5 center center NN cord-010119-t1x9gknd 7502 6 - - HYPH cord-010119-t1x9gknd 7502 7 specific specific JJ cord-010119-t1x9gknd 7502 8 and and CC cord-010119-t1x9gknd 7502 9 evolved evolve VBD cord-010119-t1x9gknd 7502 10 to to IN cord-010119-t1x9gknd 7502 11 increased increase VBN cord-010119-t1x9gknd 7502 12 levels level NNS cord-010119-t1x9gknd 7502 13 of of IN cord-010119-t1x9gknd 7502 14 matching match VBG cord-010119-t1x9gknd 7502 15 over over IN cord-010119-t1x9gknd 7502 16 the the DT cord-010119-t1x9gknd 7502 17 exposure exposure NN cord-010119-t1x9gknd 7502 18 period period NN cord-010119-t1x9gknd 7502 19 included include VBN cord-010119-t1x9gknd 7502 20 in in IN cord-010119-t1x9gknd 7502 21 this this DT cord-010119-t1x9gknd 7502 22 study study NN cord-010119-t1x9gknd 7502 23 . . . cord-010119-t1x9gknd 7503 1 Transfused transfuse VBN cord-010119-t1x9gknd 7503 2 subjects subject NNS cord-010119-t1x9gknd 7503 3 with with IN cord-010119-t1x9gknd 7503 4 11 11 CD cord-010119-t1x9gknd 7503 5 RBC RBC NNP cord-010119-t1x9gknd 7503 6 alloantibody alloantibody NN cord-010119-t1x9gknd 7503 7 of of IN cord-010119-t1x9gknd 7503 8 defined define VBN cord-010119-t1x9gknd 7503 9 specificity specificity NN cord-010119-t1x9gknd 7503 10 within within IN cord-010119-t1x9gknd 7503 11 the the DT cord-010119-t1x9gknd 7503 12 cohort cohort NN cord-010119-t1x9gknd 7503 13 were be VBD cord-010119-t1x9gknd 7503 14 compared compare VBN cord-010119-t1x9gknd 7503 15 to to IN cord-010119-t1x9gknd 7503 16 transfused transfuse VBN cord-010119-t1x9gknd 7503 17 antibody antibody NN cord-010119-t1x9gknd 7503 18 negative negative JJ cord-010119-t1x9gknd 7503 19 subjects subject NNS cord-010119-t1x9gknd 7503 20 using use VBG cord-010119-t1x9gknd 7503 21 chi chi NNP cord-010119-t1x9gknd 7503 22 squared square VBD cord-010119-t1x9gknd 7503 23 to to TO cord-010119-t1x9gknd 7503 24 compare compare VB cord-010119-t1x9gknd 7503 25 categorical categorical JJ cord-010119-t1x9gknd 7503 26 variables variable NNS cord-010119-t1x9gknd 7503 27 and and CC cord-010119-t1x9gknd 7503 28 T t NN cord-010119-t1x9gknd 7503 29 - - HYPH cord-010119-t1x9gknd 7503 30 test test NN cord-010119-t1x9gknd 7503 31 or or CC cord-010119-t1x9gknd 7503 32 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 7503 33 rank rank NN cord-010119-t1x9gknd 7503 34 - - HYPH cord-010119-t1x9gknd 7503 35 sum sum NN cord-010119-t1x9gknd 7503 36 tests test NNS cord-010119-t1x9gknd 7503 37 as as IN cord-010119-t1x9gknd 7503 38 appropriate appropriate JJ cord-010119-t1x9gknd 7503 39 to to TO cord-010119-t1x9gknd 7503 40 compare compare VB cord-010119-t1x9gknd 7503 41 continuous continuous JJ cord-010119-t1x9gknd 7503 42 variables variable NNS cord-010119-t1x9gknd 7503 43 . . . cord-010119-t1x9gknd 7504 1 Backward backward JJ cord-010119-t1x9gknd 7504 2 elimination elimination NN cord-010119-t1x9gknd 7504 3 multivariable multivariable JJ cord-010119-t1x9gknd 7504 4 logistic logistic JJ cord-010119-t1x9gknd 7504 5 modeling modeling NN cord-010119-t1x9gknd 7504 6 was be VBD cord-010119-t1x9gknd 7504 7 used use VBN cord-010119-t1x9gknd 7504 8 to to TO cord-010119-t1x9gknd 7504 9 generate generate VB cord-010119-t1x9gknd 7504 10 odds odd NNS cord-010119-t1x9gknd 7504 11 ratios ratio NNS cord-010119-t1x9gknd 7504 12 ( ( -LRB- cord-010119-t1x9gknd 7504 13 OR or CC cord-010119-t1x9gknd 7504 14 ) ) -RRB- cord-010119-t1x9gknd 7504 15 and and CC cord-010119-t1x9gknd 7504 16 identify identify VB cord-010119-t1x9gknd 7504 17 independent independent JJ cord-010119-t1x9gknd 7504 18 predictors predictor NNS cord-010119-t1x9gknd 7504 19 of of IN cord-010119-t1x9gknd 7504 20 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7504 21 using use VBG cord-010119-t1x9gknd 7504 22 results result NNS cord-010119-t1x9gknd 7504 23 of of IN cord-010119-t1x9gknd 7504 24 univariate univariate JJ cord-010119-t1x9gknd 7504 25 analyses analysis NNS cord-010119-t1x9gknd 7504 26 . . . cord-010119-t1x9gknd 7505 1 All all DT cord-010119-t1x9gknd 7505 2 subjects subject NNS cord-010119-t1x9gknd 7505 3 had have VBD cord-010119-t1x9gknd 7505 4 peripheral peripheral JJ cord-010119-t1x9gknd 7505 5 blood blood NN cord-010119-t1x9gknd 7505 6 whole whole JJ cord-010119-t1x9gknd 7505 7 genome genome NN cord-010119-t1x9gknd 7505 8 SNP SNP NNP cord-010119-t1x9gknd 7505 9 typing type VBG cord-010119-t1x9gknd 7505 10 performed perform VBD cord-010119-t1x9gknd 7505 11 using use VBG cord-010119-t1x9gknd 7505 12 an an DT cord-010119-t1x9gknd 7505 13 Affymetrix Affymetrix NNP cord-010119-t1x9gknd 7505 14 array array NN cord-010119-t1x9gknd 7505 15 , , , cord-010119-t1x9gknd 7505 16 which which WDT cord-010119-t1x9gknd 7505 17 included include VBD cord-010119-t1x9gknd 7505 18 enhanced enhanced JJ cord-010119-t1x9gknd 7505 19 content content NN cord-010119-t1x9gknd 7505 20 for for IN cord-010119-t1x9gknd 7505 21 blood blood NN cord-010119-t1x9gknd 7505 22 related relate VBN cord-010119-t1x9gknd 7505 23 SNPs snp NNS cord-010119-t1x9gknd 7505 24 . . . cord-010119-t1x9gknd 7506 1 Genome Genome NNP cord-010119-t1x9gknd 7506 2 wide wide JJ cord-010119-t1x9gknd 7506 3 association association NN cord-010119-t1x9gknd 7506 4 ( ( -LRB- cord-010119-t1x9gknd 7506 5 GWA GWA NNP cord-010119-t1x9gknd 7506 6 ) ) -RRB- cord-010119-t1x9gknd 7506 7 analyses analysis NNS cord-010119-t1x9gknd 7506 8 were be VBD cord-010119-t1x9gknd 7506 9 conducted conduct VBN cord-010119-t1x9gknd 7506 10 using use VBG cord-010119-t1x9gknd 7506 11 a a DT cord-010119-t1x9gknd 7506 12 logistic logistic JJ cord-010119-t1x9gknd 7506 13 model model NN cord-010119-t1x9gknd 7506 14 to to TO cord-010119-t1x9gknd 7506 15 identify identify VB cord-010119-t1x9gknd 7506 16 additive additive NN cord-010119-t1x9gknd 7506 17 genetic genetic JJ cord-010119-t1x9gknd 7506 18 effects effect NNS cord-010119-t1x9gknd 7506 19 associated associate VBN cord-010119-t1x9gknd 7506 20 with with IN cord-010119-t1x9gknd 7506 21 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7506 22 . . . cord-010119-t1x9gknd 7507 1 A a DT cord-010119-t1x9gknd 7507 2 p p NN cord-010119-t1x9gknd 7507 3 value value NN cord-010119-t1x9gknd 7507 4 < < XX cord-010119-t1x9gknd 7507 5 50.05 50.05 CD cord-010119-t1x9gknd 7507 6 ( ( -LRB- cord-010119-t1x9gknd 7507 7 clinical clinical JJ cord-010119-t1x9gknd 7507 8 analysis analysis NN cord-010119-t1x9gknd 7507 9 ) ) -RRB- cord-010119-t1x9gknd 7507 10 or or CC cord-010119-t1x9gknd 7507 11 < < XX cord-010119-t1x9gknd 7507 12 5x10 5x10 CD cord-010119-t1x9gknd 7507 13 -8 -8 . cord-010119-t1x9gknd 7508 1 ( ( -LRB- cord-010119-t1x9gknd 7508 2 GWA GWA NNP cord-010119-t1x9gknd 7508 3 ) ) -RRB- cord-010119-t1x9gknd 7508 4 was be VBD cord-010119-t1x9gknd 7508 5 considered consider VBN cord-010119-t1x9gknd 7508 6 statistically statistically RB cord-010119-t1x9gknd 7508 7 significant significant JJ cord-010119-t1x9gknd 7508 8 . . . cord-010119-t1x9gknd 7509 1 Results result NNS cord-010119-t1x9gknd 7510 1 /Finding /finde VBG cord-010119-t1x9gknd 7510 2 : : : cord-010119-t1x9gknd 7510 3 Of of IN cord-010119-t1x9gknd 7510 4 the the DT cord-010119-t1x9gknd 7510 5 2795 2795 CD cord-010119-t1x9gknd 7510 6 cohort cohort NN cord-010119-t1x9gknd 7510 7 patients patient NNS cord-010119-t1x9gknd 7510 8 , , , cord-010119-t1x9gknd 7510 9 2272 2272 CD cord-010119-t1x9gknd 7510 10 ( ( -LRB- cord-010119-t1x9gknd 7510 11 81.3 81.3 CD cord-010119-t1x9gknd 7510 12 % % NN cord-010119-t1x9gknd 7510 13 ) ) -RRB- cord-010119-t1x9gknd 7510 14 transfused transfuse VBN cord-010119-t1x9gknd 7510 15 subjects subject NNS cord-010119-t1x9gknd 7510 16 were be VBD cord-010119-t1x9gknd 7510 17 included include VBN cord-010119-t1x9gknd 7510 18 with with IN cord-010119-t1x9gknd 7510 19 129 129 CD cord-010119-t1x9gknd 7510 20 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 7510 21 children child NNS cord-010119-t1x9gknd 7510 22 < < XX cord-010119-t1x9gknd 7510 23 18 18 CD cord-010119-t1x9gknd 7510 24 years year NNS cord-010119-t1x9gknd 7510 25 ( ( -LRB- cord-010119-t1x9gknd 7510 26 11.0 11.0 CD cord-010119-t1x9gknd 7510 27 % % NN cord-010119-t1x9gknd 7510 28 of of IN cord-010119-t1x9gknd 7510 29 1172 1172 CD cord-010119-t1x9gknd 7510 30 ) ) -RRB- cord-010119-t1x9gknd 7510 31 and and CC cord-010119-t1x9gknd 7510 32 224 224 CD cord-010119-t1x9gknd 7510 33 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 7510 34 adults adult NNS cord-010119-t1x9gknd 7510 35 ( ( -LRB- cord-010119-t1x9gknd 7510 36 20.4 20.4 CD cord-010119-t1x9gknd 7510 37 % % NN cord-010119-t1x9gknd 7510 38 of of IN cord-010119-t1x9gknd 7510 39 1100 1100 CD cord-010119-t1x9gknd 7510 40 ) ) -RRB- cord-010119-t1x9gknd 7510 41 . . . cord-010119-t1x9gknd 7511 1 In in IN cord-010119-t1x9gknd 7511 2 multivariable multivariable JJ cord-010119-t1x9gknd 7511 3 logistic logistic JJ cord-010119-t1x9gknd 7511 4 regression regression NN cord-010119-t1x9gknd 7511 5 models model NNS cord-010119-t1x9gknd 7511 6 , , , cord-010119-t1x9gknd 7511 7 age age NN cord-010119-t1x9gknd 7511 8 ( ( -LRB- cord-010119-t1x9gknd 7511 9 OR or CC cord-010119-t1x9gknd 7511 10 4.2 4.2 CD cord-010119-t1x9gknd 7511 11 , , , cord-010119-t1x9gknd 7511 12 p50.009 p50.009 NN cord-010119-t1x9gknd 7511 13 , , , cord-010119-t1x9gknd 7511 14 for for IN cord-010119-t1x9gknd 7511 15 age age NN cord-010119-t1x9gknd 7511 16 501 501 CD cord-010119-t1x9gknd 7511 17 compared compare VBN cord-010119-t1x9gknd 7511 18 to to IN cord-010119-t1x9gknd 7511 19 0 0 CD cord-010119-t1x9gknd 7511 20 - - SYM cord-010119-t1x9gknd 7511 21 4 4 CD cord-010119-t1x9gknd 7511 22 ) ) -RRB- cord-010119-t1x9gknd 7511 23 , , , cord-010119-t1x9gknd 7511 24 gender gender NN cord-010119-t1x9gknd 7511 25 ( ( -LRB- cord-010119-t1x9gknd 7511 26 OR or CC cord-010119-t1x9gknd 7511 27 1.3 1.3 CD cord-010119-t1x9gknd 7511 28 , , , cord-010119-t1x9gknd 7511 29 p50.04 p50.04 NN cord-010119-t1x9gknd 7511 30 , , , cord-010119-t1x9gknd 7511 31 for for IN cord-010119-t1x9gknd 7511 32 female female JJ cord-010119-t1x9gknd 7511 33 compared compare VBN cord-010119-t1x9gknd 7511 34 to to IN cord-010119-t1x9gknd 7511 35 male male NN cord-010119-t1x9gknd 7511 36 ) ) -RRB- cord-010119-t1x9gknd 7511 37 , , , cord-010119-t1x9gknd 7511 38 transfusion transfusion NN cord-010119-t1x9gknd 7511 39 history history NN cord-010119-t1x9gknd 7511 40 ( ( -LRB- cord-010119-t1x9gknd 7511 41 OR or CC cord-010119-t1x9gknd 7511 42 3.5 3.5 CD cord-010119-t1x9gknd 7511 43 , , , cord-010119-t1x9gknd 7511 44 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 7511 45 , , , cord-010119-t1x9gknd 7511 46 for for IN cord-010119-t1x9gknd 7511 47 811 811 CD cord-010119-t1x9gknd 7511 48 transfusions transfusion NNS cord-010119-t1x9gknd 7511 49 compared compare VBN cord-010119-t1x9gknd 7511 50 to to IN cord-010119-t1x9gknd 7511 51 1 1 CD cord-010119-t1x9gknd 7511 52 - - SYM cord-010119-t1x9gknd 7511 53 5 5 CD cord-010119-t1x9gknd 7511 54 ) ) -RRB- cord-010119-t1x9gknd 7511 55 , , , cord-010119-t1x9gknd 7511 56 site site NN cord-010119-t1x9gknd 7511 57 , , , cord-010119-t1x9gknd 7511 58 hemolysis hemolysis NN cord-010119-t1x9gknd 7511 59 ( ( -LRB- cord-010119-t1x9gknd 7511 60 OR or CC cord-010119-t1x9gknd 7511 61 1.3 1.3 CD cord-010119-t1x9gknd 7511 62 , , , cord-010119-t1x9gknd 7511 63 p50.05 p50.05 NNP cord-010119-t1x9gknd 7511 64 , , , cord-010119-t1x9gknd 7511 65 for for IN cord-010119-t1x9gknd 7511 66 log log NN cord-010119-t1x9gknd 7511 67 transformed transform VBN cord-010119-t1x9gknd 7511 68 lactate lactate NN cord-010119-t1x9gknd 7511 69 dehydrogenase dehydrogenase NN cord-010119-t1x9gknd 7511 70 ) ) -RRB- cord-010119-t1x9gknd 7511 71 and and CC cord-010119-t1x9gknd 7511 72 presence presence NN cord-010119-t1x9gknd 7511 73 of of IN cord-010119-t1x9gknd 7511 74 autoimmune autoimmune JJ cord-010119-t1x9gknd 7511 75 disorders disorder NNS cord-010119-t1x9gknd 7511 76 ( ( -LRB- cord-010119-t1x9gknd 7511 77 OR or CC cord-010119-t1x9gknd 7511 78 4.5 4.5 CD cord-010119-t1x9gknd 7511 79 , , , cord-010119-t1x9gknd 7511 80 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 7511 81 ) ) -RRB- cord-010119-t1x9gknd 7511 82 were be VBD cord-010119-t1x9gknd 7511 83 independent independent JJ cord-010119-t1x9gknd 7511 84 predictors predictor NNS cord-010119-t1x9gknd 7511 85 of of IN cord-010119-t1x9gknd 7511 86 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7511 87 . . . cord-010119-t1x9gknd 7512 1 GWA GWA NNP cord-010119-t1x9gknd 7512 2 identified identify VBD cord-010119-t1x9gknd 7512 3 a a DT cord-010119-t1x9gknd 7512 4 single single JJ cord-010119-t1x9gknd 7512 5 SNP SNP NNP cord-010119-t1x9gknd 7512 6 of of IN cord-010119-t1x9gknd 7512 7 unclear unclear JJ cord-010119-t1x9gknd 7512 8 biologic biologic JJ cord-010119-t1x9gknd 7512 9 significance significance NN cord-010119-t1x9gknd 7512 10 associated associate VBN cord-010119-t1x9gknd 7512 11 with with IN cord-010119-t1x9gknd 7512 12 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7512 13 ( ( -LRB- cord-010119-t1x9gknd 7512 14 EEFSEC EEFSEC NNP cord-010119-t1x9gknd 7512 15 gene gene NN cord-010119-t1x9gknd 7512 16 responsible responsible JJ cord-010119-t1x9gknd 7512 17 for for IN cord-010119-t1x9gknd 7512 18 incorporation incorporation NN cord-010119-t1x9gknd 7512 19 of of IN cord-010119-t1x9gknd 7512 20 selenocysteine selenocysteine NN cord-010119-t1x9gknd 7512 21 into into IN cord-010119-t1x9gknd 7512 22 proteins protein NNS cord-010119-t1x9gknd 7512 23 ) ) -RRB- cord-010119-t1x9gknd 7512 24 . . . cord-010119-t1x9gknd 7513 1 Conclusion conclusion NN cord-010119-t1x9gknd 7513 2 : : : cord-010119-t1x9gknd 7514 1 RBC RBC NNP cord-010119-t1x9gknd 7514 2 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7514 3 is be VBZ cord-010119-t1x9gknd 7514 4 primarily primarily RB cord-010119-t1x9gknd 7514 5 driven drive VBN cord-010119-t1x9gknd 7514 6 by by IN cord-010119-t1x9gknd 7514 7 transfusion transfusion NN cord-010119-t1x9gknd 7514 8 burden burden NN cord-010119-t1x9gknd 7514 9 in in IN cord-010119-t1x9gknd 7514 10 this this DT cord-010119-t1x9gknd 7514 11 SCD SCD NNP cord-010119-t1x9gknd 7514 12 cohort cohort NN cord-010119-t1x9gknd 7514 13 . . . cord-010119-t1x9gknd 7515 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 7515 2 remained remain VBD cord-010119-t1x9gknd 7515 3 significantly significantly RB cord-010119-t1x9gknd 7515 4 associated associate VBN cord-010119-t1x9gknd 7515 5 with with IN cord-010119-t1x9gknd 7515 6 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7515 7 after after IN cord-010119-t1x9gknd 7515 8 controlling control VBG cord-010119-t1x9gknd 7515 9 for for IN cord-010119-t1x9gknd 7515 10 transfusions transfusion NNS cord-010119-t1x9gknd 7515 11 . . . cord-010119-t1x9gknd 7516 1 Presence presence NN cord-010119-t1x9gknd 7516 2 of of IN cord-010119-t1x9gknd 7516 3 an an DT cord-010119-t1x9gknd 7516 4 autoimmune autoimmune JJ cord-010119-t1x9gknd 7516 5 disease disease NN cord-010119-t1x9gknd 7516 6 was be VBD cord-010119-t1x9gknd 7516 7 also also RB cord-010119-t1x9gknd 7516 8 associated associate VBN cord-010119-t1x9gknd 7516 9 with with IN cord-010119-t1x9gknd 7516 10 RBC RBC NNP cord-010119-t1x9gknd 7516 11 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7516 12 , , , cord-010119-t1x9gknd 7516 13 indicating indicate VBG cord-010119-t1x9gknd 7516 14 more more RBR cord-010119-t1x9gknd 7516 15 systemic systemic JJ cord-010119-t1x9gknd 7516 16 immune immune JJ cord-010119-t1x9gknd 7516 17 dysregulation dysregulation NN cord-010119-t1x9gknd 7516 18 may may MD cord-010119-t1x9gknd 7516 19 be be VB cord-010119-t1x9gknd 7516 20 present present JJ cord-010119-t1x9gknd 7516 21 in in IN cord-010119-t1x9gknd 7516 22 SCD SCD NNP cord-010119-t1x9gknd 7516 23 patients patient NNS cord-010119-t1x9gknd 7516 24 who who WP cord-010119-t1x9gknd 7516 25 develop develop VBP cord-010119-t1x9gknd 7516 26 RBC RBC NNP cord-010119-t1x9gknd 7516 27 alloantibodies alloantibody NNS cord-010119-t1x9gknd 7516 28 . . . cord-010119-t1x9gknd 7517 1 However however RB cord-010119-t1x9gknd 7517 2 , , , cord-010119-t1x9gknd 7517 3 the the DT cord-010119-t1x9gknd 7517 4 GWA GWA NNP cord-010119-t1x9gknd 7517 5 did do VBD cord-010119-t1x9gknd 7517 6 not not RB cord-010119-t1x9gknd 7517 7 identify identify VB cord-010119-t1x9gknd 7517 8 SNPs snp NNS cord-010119-t1x9gknd 7517 9 in in IN cord-010119-t1x9gknd 7517 10 immunoregulatory immunoregulatory NNP cord-010119-t1x9gknd 7517 11 genes gene NNS cord-010119-t1x9gknd 7517 12 significantly significantly RB cord-010119-t1x9gknd 7517 13 associated associate VBD cord-010119-t1x9gknd 7517 14 with with IN cord-010119-t1x9gknd 7517 15 RBC RBC NNP cord-010119-t1x9gknd 7517 16 antibody antibody NN cord-010119-t1x9gknd 7517 17 formation formation NN cord-010119-t1x9gknd 7517 18 in in IN cord-010119-t1x9gknd 7517 19 the the DT cord-010119-t1x9gknd 7517 20 study study NN cord-010119-t1x9gknd 7517 21 population population NN cord-010119-t1x9gknd 7517 22 . . . cord-010119-t1x9gknd 7518 1 Background Background NNP cord-010119-t1x9gknd 7518 2 / / SYM cord-010119-t1x9gknd 7518 3 Case Case NNP cord-010119-t1x9gknd 7518 4 Studies Studies NNPS cord-010119-t1x9gknd 7518 5 : : : cord-010119-t1x9gknd 7518 6 Physiologic physiologic JJ cord-010119-t1x9gknd 7518 7 anemia anemia NN cord-010119-t1x9gknd 7518 8 is be VBZ cord-010119-t1x9gknd 7518 9 more more RBR cord-010119-t1x9gknd 7518 10 severe severe JJ cord-010119-t1x9gknd 7518 11 in in IN cord-010119-t1x9gknd 7518 12 preterm preterm JJ cord-010119-t1x9gknd 7518 13 infants infant NNS cord-010119-t1x9gknd 7518 14 and and CC cord-010119-t1x9gknd 7518 15 worsened worsen VBN cord-010119-t1x9gknd 7518 16 by by IN cord-010119-t1x9gknd 7518 17 the the DT cord-010119-t1x9gknd 7518 18 blood blood NN cord-010119-t1x9gknd 7518 19 loss loss NN cord-010119-t1x9gknd 7518 20 required require VBN cord-010119-t1x9gknd 7518 21 for for IN cord-010119-t1x9gknd 7518 22 laboratory laboratory NN cord-010119-t1x9gknd 7518 23 tests test NNS cord-010119-t1x9gknd 7518 24 . . . cord-010119-t1x9gknd 7519 1 To to TO cord-010119-t1x9gknd 7519 2 reduce reduce VB cord-010119-t1x9gknd 7519 3 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 7519 4 anemia anemia NN cord-010119-t1x9gknd 7519 5 , , , cord-010119-t1x9gknd 7519 6 placental placental JJ cord-010119-t1x9gknd 7519 7 blood blood NN cord-010119-t1x9gknd 7519 8 , , , cord-010119-t1x9gknd 7519 9 which which WDT cord-010119-t1x9gknd 7519 10 otherwise otherwise RB cord-010119-t1x9gknd 7519 11 would would MD cord-010119-t1x9gknd 7519 12 be be VB cord-010119-t1x9gknd 7519 13 discarded discard VBN cord-010119-t1x9gknd 7519 14 , , , cord-010119-t1x9gknd 7519 15 can can MD cord-010119-t1x9gknd 7519 16 be be VB cord-010119-t1x9gknd 7519 17 used use VBN cord-010119-t1x9gknd 7519 18 for for IN cord-010119-t1x9gknd 7519 19 laboratory laboratory NN cord-010119-t1x9gknd 7519 20 testing testing NN cord-010119-t1x9gknd 7519 21 . . . cord-010119-t1x9gknd 7520 1 Mother mother NN cord-010119-t1x9gknd 7520 2 and and CC cord-010119-t1x9gknd 7520 3 infant infant NN cord-010119-t1x9gknd 7520 4 blood blood NN cord-010119-t1x9gknd 7520 5 are be VBP cord-010119-t1x9gknd 7520 6 mixed mix VBN cord-010119-t1x9gknd 7520 7 in in IN cord-010119-t1x9gknd 7520 8 the the DT cord-010119-t1x9gknd 7520 9 placenta placenta NN cord-010119-t1x9gknd 7520 10 during during IN cord-010119-t1x9gknd 7520 11 delivery delivery NN cord-010119-t1x9gknd 7520 12 and and CC cord-010119-t1x9gknd 7520 13 pre pre JJ cord-010119-t1x9gknd 7520 14 - - JJ cord-010119-t1x9gknd 7520 15 transfusion transfusion JJ cord-010119-t1x9gknd 7520 16 test test NN cord-010119-t1x9gknd 7520 17 results result NNS cord-010119-t1x9gknd 7520 18 potentially potentially RB cord-010119-t1x9gknd 7520 19 can can MD cord-010119-t1x9gknd 7520 20 be be VB cord-010119-t1x9gknd 7520 21 altered alter VBN cord-010119-t1x9gknd 7520 22 due due IN cord-010119-t1x9gknd 7520 23 to to IN cord-010119-t1x9gknd 7520 24 fetal fetal JJ cord-010119-t1x9gknd 7520 25 - - HYPH cord-010119-t1x9gknd 7520 26 maternal maternal JJ cord-010119-t1x9gknd 7520 27 hemorrhage hemorrhage NN cord-010119-t1x9gknd 7520 28 . . . cord-010119-t1x9gknd 7521 1 There there EX cord-010119-t1x9gknd 7521 2 has have VBZ cord-010119-t1x9gknd 7521 3 been be VBN cord-010119-t1x9gknd 7521 4 no no DT cord-010119-t1x9gknd 7521 5 published publish VBN cord-010119-t1x9gknd 7521 6 study study NN cord-010119-t1x9gknd 7521 7 to to TO cord-010119-t1x9gknd 7521 8 show show VB cord-010119-t1x9gknd 7521 9 if if IN cord-010119-t1x9gknd 7521 10 pre pre JJ cord-010119-t1x9gknd 7521 11 - - JJ cord-010119-t1x9gknd 7521 12 transfusion transfusion JJ cord-010119-t1x9gknd 7521 13 test test NN cord-010119-t1x9gknd 7521 14 results result NNS cord-010119-t1x9gknd 7521 15 of of IN cord-010119-t1x9gknd 7521 16 placental placental JJ cord-010119-t1x9gknd 7521 17 blood blood NN cord-010119-t1x9gknd 7521 18 give give VBP cord-010119-t1x9gknd 7521 19 the the DT cord-010119-t1x9gknd 7521 20 same same JJ cord-010119-t1x9gknd 7521 21 result result NN cord-010119-t1x9gknd 7521 22 as as IN cord-010119-t1x9gknd 7521 23 the the DT cord-010119-t1x9gknd 7521 24 heel heel NN cord-010119-t1x9gknd 7521 25 stick stick NN cord-010119-t1x9gknd 7521 26 samples sample NNS cord-010119-t1x9gknd 7521 27 , , , cord-010119-t1x9gknd 7521 28 which which WDT cord-010119-t1x9gknd 7521 29 is be VBZ cord-010119-t1x9gknd 7521 30 the the DT cord-010119-t1x9gknd 7521 31 standard standard NN cord-010119-t1x9gknd 7521 32 of of IN cord-010119-t1x9gknd 7521 33 practice practice NN cord-010119-t1x9gknd 7521 34 . . . cord-010119-t1x9gknd 7522 1 Study Study NNP cord-010119-t1x9gknd 7522 2 Design Design NNP cord-010119-t1x9gknd 7522 3 / / SYM cord-010119-t1x9gknd 7522 4 Methods method NNS cord-010119-t1x9gknd 7522 5 : : : cord-010119-t1x9gknd 7523 1 Transfusion Transfusion NNP cord-010119-t1x9gknd 7523 2 Service Service NNP cord-010119-t1x9gknd 7523 3 tested test VBD cord-010119-t1x9gknd 7523 4 sample sample NN cord-010119-t1x9gknd 7523 5 pairs pair NNS cord-010119-t1x9gknd 7523 6 from from IN cord-010119-t1x9gknd 7523 7 32 32 CD cord-010119-t1x9gknd 7523 8 newborns newborn NNS cord-010119-t1x9gknd 7523 9 less less JJR cord-010119-t1x9gknd 7523 10 than than IN cord-010119-t1x9gknd 7523 11 2,000 2,000 CD cord-010119-t1x9gknd 7523 12 gr gr NNP cord-010119-t1x9gknd 7523 13 birth birth NN cord-010119-t1x9gknd 7523 14 weight weight NN cord-010119-t1x9gknd 7523 15 . . . cord-010119-t1x9gknd 7524 1 One one CD cord-010119-t1x9gknd 7524 2 of of IN cord-010119-t1x9gknd 7524 3 the the DT cord-010119-t1x9gknd 7524 4 samples sample NNS cord-010119-t1x9gknd 7524 5 was be VBD cord-010119-t1x9gknd 7524 6 collected collect VBN cord-010119-t1x9gknd 7524 7 from from IN cord-010119-t1x9gknd 7524 8 the the DT cord-010119-t1x9gknd 7524 9 newborn newborn NN cord-010119-t1x9gknd 7524 10 as as IN cord-010119-t1x9gknd 7524 11 a a DT cord-010119-t1x9gknd 7524 12 heel heel NN cord-010119-t1x9gknd 7524 13 stick stick NN cord-010119-t1x9gknd 7524 14 sample sample NN cord-010119-t1x9gknd 7524 15 , , , cord-010119-t1x9gknd 7524 16 the the DT cord-010119-t1x9gknd 7524 17 other other JJ cord-010119-t1x9gknd 7524 18 from from IN cord-010119-t1x9gknd 7524 19 the the DT cord-010119-t1x9gknd 7524 20 placenta placenta NN cord-010119-t1x9gknd 7524 21 . . . cord-010119-t1x9gknd 7525 1 The the DT cord-010119-t1x9gknd 7525 2 following follow VBG cord-010119-t1x9gknd 7525 3 tests test NNS cord-010119-t1x9gknd 7525 4 were be VBD cord-010119-t1x9gknd 7525 5 performed perform VBN cord-010119-t1x9gknd 7525 6 on on IN cord-010119-t1x9gknd 7525 7 the the DT cord-010119-t1x9gknd 7525 8 sample sample NN cord-010119-t1x9gknd 7525 9 pairs pair NNS cord-010119-t1x9gknd 7525 10 : : : cord-010119-t1x9gknd 7525 11 ABO ABO NNP cord-010119-t1x9gknd 7525 12 , , , cord-010119-t1x9gknd 7525 13 Rh Rh NNP cord-010119-t1x9gknd 7525 14 , , , cord-010119-t1x9gknd 7525 15 antibody antibody NN cord-010119-t1x9gknd 7525 16 screen screen NN cord-010119-t1x9gknd 7525 17 and and CC cord-010119-t1x9gknd 7525 18 Direct Direct NNP cord-010119-t1x9gknd 7525 19 Antiglobulin Antiglobulin NNP cord-010119-t1x9gknd 7525 20 Test Test NNP cord-010119-t1x9gknd 7525 21 with with IN cord-010119-t1x9gknd 7525 22 IgG igg NN cord-010119-t1x9gknd 7525 23 ( ( -LRB- cord-010119-t1x9gknd 7525 24 DAT DAT NNP cord-010119-t1x9gknd 7525 25 ) ) -RRB- cord-010119-t1x9gknd 7525 26 . . . cord-010119-t1x9gknd 7526 1 Results result NNS cord-010119-t1x9gknd 7526 2 / / SYM cord-010119-t1x9gknd 7526 3 Findings finding NNS cord-010119-t1x9gknd 7526 4 : : : cord-010119-t1x9gknd 7526 5 ABO ABO NNP cord-010119-t1x9gknd 7526 6 , , , cord-010119-t1x9gknd 7526 7 Rh Rh NNP cord-010119-t1x9gknd 7526 8 and and CC cord-010119-t1x9gknd 7526 9 DAT DAT NNP cord-010119-t1x9gknd 7526 10 tests test NNS cord-010119-t1x9gknd 7526 11 were be VBD cord-010119-t1x9gknd 7526 12 performed perform VBN cord-010119-t1x9gknd 7526 13 on on IN cord-010119-t1x9gknd 7526 14 32 32 CD cord-010119-t1x9gknd 7526 15 sample sample NN cord-010119-t1x9gknd 7526 16 pairs pair NNS cord-010119-t1x9gknd 7526 17 . . . cord-010119-t1x9gknd 7527 1 DAT DAT NNP cord-010119-t1x9gknd 7527 2 test test NN cord-010119-t1x9gknd 7527 3 was be VBD cord-010119-t1x9gknd 7527 4 negative negative JJ cord-010119-t1x9gknd 7527 5 on on IN cord-010119-t1x9gknd 7527 6 30 30 CD cord-010119-t1x9gknd 7527 7 sample sample NN cord-010119-t1x9gknd 7527 8 pairs pair NNS cord-010119-t1x9gknd 7527 9 and and CC cord-010119-t1x9gknd 7527 10 two two CD cord-010119-t1x9gknd 7527 11 were be VBD cord-010119-t1x9gknd 7527 12 positive positive JJ cord-010119-t1x9gknd 7527 13 . . . cord-010119-t1x9gknd 7528 1 There there EX cord-010119-t1x9gknd 7528 2 was be VBD cord-010119-t1x9gknd 7528 3 100 100 CD cord-010119-t1x9gknd 7528 4 % % NN cord-010119-t1x9gknd 7528 5 concordance concordance NN cord-010119-t1x9gknd 7528 6 with with IN cord-010119-t1x9gknd 7528 7 the the DT cord-010119-t1x9gknd 7528 8 ABO ABO NNP cord-010119-t1x9gknd 7528 9 , , , cord-010119-t1x9gknd 7528 10 Rh Rh NNP cord-010119-t1x9gknd 7528 11 and and CC cord-010119-t1x9gknd 7528 12 DAT DAT NNP cord-010119-t1x9gknd 7528 13 tests test NNS cord-010119-t1x9gknd 7528 14 performed perform VBN cord-010119-t1x9gknd 7528 15 on on IN cord-010119-t1x9gknd 7528 16 these these DT cord-010119-t1x9gknd 7528 17 sample sample NN cord-010119-t1x9gknd 7528 18 pairs pair NNS cord-010119-t1x9gknd 7528 19 . . . cord-010119-t1x9gknd 7529 1 Antibody antibody NN cord-010119-t1x9gknd 7529 2 screen screen NN cord-010119-t1x9gknd 7529 3 was be VBD cord-010119-t1x9gknd 7529 4 performed perform VBN cord-010119-t1x9gknd 7529 5 on on IN cord-010119-t1x9gknd 7529 6 32 32 CD cord-010119-t1x9gknd 7529 7 placental placental JJ cord-010119-t1x9gknd 7529 8 blood blood NN cord-010119-t1x9gknd 7529 9 samples sample NNS cord-010119-t1x9gknd 7529 10 and and CC cord-010119-t1x9gknd 7529 11 29 29 CD cord-010119-t1x9gknd 7529 12 heel heel NN cord-010119-t1x9gknd 7529 13 stick stick NN cord-010119-t1x9gknd 7529 14 samples sample NNS cord-010119-t1x9gknd 7529 15 . . . cord-010119-t1x9gknd 7530 1 Twenty twenty CD cord-010119-t1x9gknd 7530 2 eight eight CD cord-010119-t1x9gknd 7530 3 sample sample NN cord-010119-t1x9gknd 7530 4 pairs pair NNS cord-010119-t1x9gknd 7530 5 were be VBD cord-010119-t1x9gknd 7530 6 negative negative JJ cord-010119-t1x9gknd 7530 7 with with IN cord-010119-t1x9gknd 7530 8 the the DT cord-010119-t1x9gknd 7530 9 antibody antibody NN cord-010119-t1x9gknd 7530 10 screening screening NN cord-010119-t1x9gknd 7530 11 test test NN cord-010119-t1x9gknd 7530 12 . . . cord-010119-t1x9gknd 7531 1 There there EX cord-010119-t1x9gknd 7531 2 was be VBD cord-010119-t1x9gknd 7531 3 one one CD cord-010119-t1x9gknd 7531 4 positive positive JJ cord-010119-t1x9gknd 7531 5 heel heel NN cord-010119-t1x9gknd 7531 6 stick stick NN cord-010119-t1x9gknd 7531 7 sample sample NN cord-010119-t1x9gknd 7531 8 , , , cord-010119-t1x9gknd 7531 9 which which WDT cord-010119-t1x9gknd 7531 10 was be VBD cord-010119-t1x9gknd 7531 11 also also RB cord-010119-t1x9gknd 7531 12 positive positive JJ cord-010119-t1x9gknd 7531 13 using use VBG cord-010119-t1x9gknd 7531 14 the the DT cord-010119-t1x9gknd 7531 15 placental placental JJ cord-010119-t1x9gknd 7531 16 sample sample NN cord-010119-t1x9gknd 7531 17 . . . cord-010119-t1x9gknd 7532 1 One one CD cord-010119-t1x9gknd 7532 2 heel heel NN cord-010119-t1x9gknd 7532 3 stick stick NN cord-010119-t1x9gknd 7532 4 sample sample NN cord-010119-t1x9gknd 7532 5 was be VBD cord-010119-t1x9gknd 7532 6 negative negative JJ cord-010119-t1x9gknd 7532 7 for for IN cord-010119-t1x9gknd 7532 8 the the DT cord-010119-t1x9gknd 7532 9 presence presence NN cord-010119-t1x9gknd 7532 10 of of IN cord-010119-t1x9gknd 7532 11 an an DT cord-010119-t1x9gknd 7532 12 antibody antibody NN cord-010119-t1x9gknd 7532 13 but but CC cord-010119-t1x9gknd 7532 14 found find VBD cord-010119-t1x9gknd 7532 15 to to TO cord-010119-t1x9gknd 7532 16 be be VB cord-010119-t1x9gknd 7532 17 positive positive JJ cord-010119-t1x9gknd 7532 18 with with IN cord-010119-t1x9gknd 7532 19 the the DT cord-010119-t1x9gknd 7532 20 placental placental JJ cord-010119-t1x9gknd 7532 21 blood blood NN cord-010119-t1x9gknd 7532 22 sample sample NN cord-010119-t1x9gknd 7532 23 . . . cord-010119-t1x9gknd 7533 1 This this DT cord-010119-t1x9gknd 7533 2 antibody antibody NN cord-010119-t1x9gknd 7533 3 which which WDT cord-010119-t1x9gknd 7533 4 was be VBD cord-010119-t1x9gknd 7533 5 detected detect VBN cord-010119-t1x9gknd 7533 6 only only RB cord-010119-t1x9gknd 7533 7 in in IN cord-010119-t1x9gknd 7533 8 the the DT cord-010119-t1x9gknd 7533 9 placental placental NN cord-010119-t1x9gknd 7533 10 sample sample NN cord-010119-t1x9gknd 7533 11 was be VBD cord-010119-t1x9gknd 7533 12 a a DT cord-010119-t1x9gknd 7533 13 passive passive JJ cord-010119-t1x9gknd 7533 14 anti anti JJ cord-010119-t1x9gknd 7533 15 - - JJ cord-010119-t1x9gknd 7533 16 D d JJ cord-010119-t1x9gknd 7533 17 mother mother NN cord-010119-t1x9gknd 7533 18 received receive VBD cord-010119-t1x9gknd 7533 19 during during IN cord-010119-t1x9gknd 7533 20 pregnancy pregnancy NN cord-010119-t1x9gknd 7533 21 . . . cord-010119-t1x9gknd 7534 1 This this DT cord-010119-t1x9gknd 7534 2 discrepant discrepant JJ cord-010119-t1x9gknd 7534 3 result result NN cord-010119-t1x9gknd 7534 4 indicates indicate VBZ cord-010119-t1x9gknd 7534 5 that that IN cord-010119-t1x9gknd 7534 6 the the DT cord-010119-t1x9gknd 7534 7 placental placental JJ cord-010119-t1x9gknd 7534 8 blood blood NN cord-010119-t1x9gknd 7534 9 sample sample NN cord-010119-t1x9gknd 7534 10 was be VBD cord-010119-t1x9gknd 7534 11 more more RBR cord-010119-t1x9gknd 7534 12 sensitive sensitive JJ cord-010119-t1x9gknd 7534 13 to to TO cord-010119-t1x9gknd 7534 14 detect detect VB cord-010119-t1x9gknd 7534 15 a a DT cord-010119-t1x9gknd 7534 16 weak weak JJ cord-010119-t1x9gknd 7534 17 antibody antibody NN cord-010119-t1x9gknd 7534 18 . . . cord-010119-t1x9gknd 7535 1 Conclusion conclusion NN cord-010119-t1x9gknd 7535 2 : : : cord-010119-t1x9gknd 7536 1 This this DT cord-010119-t1x9gknd 7536 2 study study NN cord-010119-t1x9gknd 7536 3 shows show VBZ cord-010119-t1x9gknd 7536 4 that that IN cord-010119-t1x9gknd 7536 5 placental placental JJ cord-010119-t1x9gknd 7536 6 blood blood NN cord-010119-t1x9gknd 7536 7 sample sample NN cord-010119-t1x9gknd 7536 8 is be VBZ cord-010119-t1x9gknd 7536 9 not not RB cord-010119-t1x9gknd 7536 10 inferior inferior JJ cord-010119-t1x9gknd 7536 11 to to TO cord-010119-t1x9gknd 7536 12 heel heel VB cord-010119-t1x9gknd 7536 13 stick stick VB cord-010119-t1x9gknd 7536 14 sample sample NN cord-010119-t1x9gknd 7536 15 regarding regard VBG cord-010119-t1x9gknd 7536 16 ABO ABO NNP cord-010119-t1x9gknd 7536 17 , , , cord-010119-t1x9gknd 7536 18 Rh Rh NNP cord-010119-t1x9gknd 7536 19 and and CC cord-010119-t1x9gknd 7536 20 DAT DAT NNP cord-010119-t1x9gknd 7536 21 testing testing NN cord-010119-t1x9gknd 7536 22 . . . cord-010119-t1x9gknd 7537 1 Based base VBN cord-010119-t1x9gknd 7537 2 on on IN cord-010119-t1x9gknd 7537 3 this this DT cord-010119-t1x9gknd 7537 4 comparison comparison NN cord-010119-t1x9gknd 7537 5 study study NN cord-010119-t1x9gknd 7537 6 placental placental JJ cord-010119-t1x9gknd 7537 7 blood blood NN cord-010119-t1x9gknd 7537 8 can can MD cord-010119-t1x9gknd 7537 9 be be VB cord-010119-t1x9gknd 7537 10 used use VBN cord-010119-t1x9gknd 7537 11 for for IN cord-010119-t1x9gknd 7537 12 pre pre JJ cord-010119-t1x9gknd 7537 13 - - JJ cord-010119-t1x9gknd 7537 14 transfusion transfusion JJ cord-010119-t1x9gknd 7537 15 testing testing NN cord-010119-t1x9gknd 7537 16 for for IN cord-010119-t1x9gknd 7537 17 < < XX cord-010119-t1x9gknd 7537 18 2,000 2,000 CD cord-010119-t1x9gknd 7537 19 g g NN cord-010119-t1x9gknd 7537 20 birth birth NN cord-010119-t1x9gknd 7537 21 weight weight NN cord-010119-t1x9gknd 7537 22 newborns newborn NNS cord-010119-t1x9gknd 7537 23 . . . cord-010119-t1x9gknd 7538 1 O-(7.4 o-(7.4 CD cord-010119-t1x9gknd 7538 2 % % NN cord-010119-t1x9gknd 7538 3 ) ) -RRB- cord-010119-t1x9gknd 7538 4 , , , cord-010119-t1x9gknd 7538 5 AB1(6.8 ab1(6.8 NN cord-010119-t1x9gknd 7538 6 % % NN cord-010119-t1x9gknd 7538 7 ) ) -RRB- cord-010119-t1x9gknd 7538 8 , , , cord-010119-t1x9gknd 7538 9 B-(2.7 b-(2.7 CD cord-010119-t1x9gknd 7538 10 % % NN cord-010119-t1x9gknd 7538 11 ) ) -RRB- cord-010119-t1x9gknd 7538 12 , , , cord-010119-t1x9gknd 7538 13 and and CC cord-010119-t1x9gknd 7538 14 A-(0.6 a-(0.6 CD cord-010119-t1x9gknd 7538 15 % % NN cord-010119-t1x9gknd 7538 16 ) ) -RRB- cord-010119-t1x9gknd 7538 17 . . . cord-010119-t1x9gknd 7539 1 Among among IN cord-010119-t1x9gknd 7539 2 the the DT cord-010119-t1x9gknd 7539 3 tested test VBN cord-010119-t1x9gknd 7539 4 donors donor NNS cord-010119-t1x9gknd 7539 5 , , , cord-010119-t1x9gknd 7539 6 89.2 89.2 CD cord-010119-t1x9gknd 7539 7 % % NN cord-010119-t1x9gknd 7539 8 were be VBD cord-010119-t1x9gknd 7539 9 D D VBN cord-010119-t1x9gknd 7539 10 positive positive JJ cord-010119-t1x9gknd 7539 11 with with IN cord-010119-t1x9gknd 7539 12 R1r r1r NN cord-010119-t1x9gknd 7539 13 being be VBG cord-010119-t1x9gknd 7539 14 the the DT cord-010119-t1x9gknd 7539 15 most most RBS cord-010119-t1x9gknd 7539 16 common common JJ cord-010119-t1x9gknd 7539 17 Rh Rh NNP cord-010119-t1x9gknd 7539 18 phenotype phenotype NN cord-010119-t1x9gknd 7539 19 . . . cord-010119-t1x9gknd 7540 1 In in IN cord-010119-t1x9gknd 7540 2 the the DT cord-010119-t1x9gknd 7540 3 Kell Kell NNP cord-010119-t1x9gknd 7540 4 blood blood NN cord-010119-t1x9gknd 7540 5 group group NN cord-010119-t1x9gknd 7540 6 system system NN cord-010119-t1x9gknd 7540 7 , , , cord-010119-t1x9gknd 7540 8 4.5 4.5 CD cord-010119-t1x9gknd 7540 9 % % NN cord-010119-t1x9gknd 7540 10 of of IN cord-010119-t1x9gknd 7540 11 the the DT cord-010119-t1x9gknd 7540 12 donors donor NNS cord-010119-t1x9gknd 7540 13 were be VBD cord-010119-t1x9gknd 7540 14 K K NNP cord-010119-t1x9gknd 7540 15 positive positive JJ cord-010119-t1x9gknd 7540 16 , , , cord-010119-t1x9gknd 7540 17 while while IN cord-010119-t1x9gknd 7540 18 the the DT cord-010119-t1x9gknd 7540 19 k k NNP cord-010119-t1x9gknd 7540 20 antigen antigen NNP cord-010119-t1x9gknd 7540 21 was be VBD cord-010119-t1x9gknd 7540 22 found find VBN cord-010119-t1x9gknd 7540 23 to to TO cord-010119-t1x9gknd 7540 24 be be VB cord-010119-t1x9gknd 7540 25 99.4 99.4 CD cord-010119-t1x9gknd 7540 26 % % NN cord-010119-t1x9gknd 7540 27 . . . cord-010119-t1x9gknd 7541 1 The the DT cord-010119-t1x9gknd 7541 2 most most RBS cord-010119-t1x9gknd 7541 3 common common JJ cord-010119-t1x9gknd 7541 4 phenotype phenotype NN cord-010119-t1x9gknd 7541 5 in in IN cord-010119-t1x9gknd 7541 6 the the DT cord-010119-t1x9gknd 7541 7 Duffy Duffy NNP cord-010119-t1x9gknd 7541 8 blood blood NN cord-010119-t1x9gknd 7541 9 group group NN cord-010119-t1x9gknd 7541 10 system system NN cord-010119-t1x9gknd 7541 11 was be VBD cord-010119-t1x9gknd 7541 12 Fy(a Fy(a NNP cord-010119-t1x9gknd 7541 13 - - HYPH cord-010119-t1x9gknd 7541 14 b- b- NNP cord-010119-t1x9gknd 7541 15 ) ) -RRB- cord-010119-t1x9gknd 7541 16 , , , cord-010119-t1x9gknd 7541 17 while while IN cord-010119-t1x9gknd 7541 18 the the DT cord-010119-t1x9gknd 7541 19 Fy(a1b1 Fy(a1b1 NNP cord-010119-t1x9gknd 7541 20 ) ) -RRB- cord-010119-t1x9gknd 7541 21 was be VBD cord-010119-t1x9gknd 7541 22 found find VBN cord-010119-t1x9gknd 7541 23 at at IN cord-010119-t1x9gknd 7541 24 a a DT cord-010119-t1x9gknd 7541 25 higher high JJR cord-010119-t1x9gknd 7541 26 frequency frequency NN cord-010119-t1x9gknd 7541 27 compared compare VBN cord-010119-t1x9gknd 7541 28 to to IN cord-010119-t1x9gknd 7541 29 what what WP cord-010119-t1x9gknd 7541 30 has have VBZ cord-010119-t1x9gknd 7541 31 been be VBN cord-010119-t1x9gknd 7541 32 reported report VBN cord-010119-t1x9gknd 7541 33 in in IN cord-010119-t1x9gknd 7541 34 the the DT cord-010119-t1x9gknd 7541 35 black black JJ cord-010119-t1x9gknd 7541 36 population population NN cord-010119-t1x9gknd 7541 37 . . . cord-010119-t1x9gknd 7542 1 ( ( -LRB- cord-010119-t1x9gknd 7542 2 Table table NN cord-010119-t1x9gknd 7542 3 ) ) -RRB- cord-010119-t1x9gknd 7543 1 The the DT cord-010119-t1x9gknd 7543 2 commonest common JJS cord-010119-t1x9gknd 7543 3 phenotypes phenotype NNS cord-010119-t1x9gknd 7543 4 for for IN cord-010119-t1x9gknd 7543 5 the the DT cord-010119-t1x9gknd 7543 6 Kidd Kidd NNP cord-010119-t1x9gknd 7543 7 and and CC cord-010119-t1x9gknd 7543 8 MNS MNS NNP cord-010119-t1x9gknd 7543 9 blood blood NN cord-010119-t1x9gknd 7543 10 group group NN cord-010119-t1x9gknd 7543 11 systems system NNS cord-010119-t1x9gknd 7543 12 were be VBD cord-010119-t1x9gknd 7543 13 Jk(a1b1 Jk(a1b1 NNP cord-010119-t1x9gknd 7543 14 ) ) -RRB- cord-010119-t1x9gknd 7543 15 and and CC cord-010119-t1x9gknd 7544 1 M1N M1N NNP cord-010119-t1x9gknd 7544 2 - - HYPH cord-010119-t1x9gknd 7544 3 S1s1 S1s1 NNP cord-010119-t1x9gknd 7544 4 at at IN cord-010119-t1x9gknd 7544 5 47 47 CD cord-010119-t1x9gknd 7544 6 % % NN cord-010119-t1x9gknd 7544 7 and and CC cord-010119-t1x9gknd 7544 8 22.6 22.6 CD cord-010119-t1x9gknd 7544 9 % % NN cord-010119-t1x9gknd 7544 10 respectively respectively RB cord-010119-t1x9gknd 7544 11 . . . cord-010119-t1x9gknd 7545 1 The the DT cord-010119-t1x9gknd 7545 2 Le Le NNP cord-010119-t1x9gknd 7545 3 a a DT cord-010119-t1x9gknd 7545 4 1 1 CD cord-010119-t1x9gknd 7545 5 and and CC cord-010119-t1x9gknd 7545 6 Le Le NNP cord-010119-t1x9gknd 7545 7 b b NNP cord-010119-t1x9gknd 7545 8 1 1 CD cord-010119-t1x9gknd 7545 9 alleles allele NNS cord-010119-t1x9gknd 7545 10 were be VBD cord-010119-t1x9gknd 7545 11 seen see VBN cord-010119-t1x9gknd 7545 12 in in IN cord-010119-t1x9gknd 7545 13 21.7 21.7 CD cord-010119-t1x9gknd 7545 14 % % NN cord-010119-t1x9gknd 7545 15 and and CC cord-010119-t1x9gknd 7545 16 67.3 67.3 CD cord-010119-t1x9gknd 7545 17 % % NN cord-010119-t1x9gknd 7545 18 of of IN cord-010119-t1x9gknd 7545 19 donors donor NNS cord-010119-t1x9gknd 7545 20 respectively respectively RB cord-010119-t1x9gknd 7545 21 , , , cord-010119-t1x9gknd 7545 22 while while IN cord-010119-t1x9gknd 7545 23 Lu Lu NNP cord-010119-t1x9gknd 7545 24 b b NNP cord-010119-t1x9gknd 7545 25 -phenotype -phenotype : cord-010119-t1x9gknd 7545 26 was be VBD cord-010119-t1x9gknd 7545 27 found find VBN cord-010119-t1x9gknd 7545 28 in in IN cord-010119-t1x9gknd 7545 29 3.3 3.3 CD cord-010119-t1x9gknd 7545 30 % % NN cord-010119-t1x9gknd 7545 31 of of IN cord-010119-t1x9gknd 7545 32 the the DT cord-010119-t1x9gknd 7545 33 donors donor NNS cord-010119-t1x9gknd 7545 34 . . . cord-010119-t1x9gknd 7546 1 The the DT cord-010119-t1x9gknd 7546 2 frequencies frequency NNS cord-010119-t1x9gknd 7546 3 of of IN cord-010119-t1x9gknd 7546 4 the the DT cord-010119-t1x9gknd 7546 5 rare rare JJ cord-010119-t1x9gknd 7546 6 phenotypes phenotype NNS cord-010119-t1x9gknd 7546 7 Jk(a Jk(a NNP cord-010119-t1x9gknd 7546 8 - - HYPH cord-010119-t1x9gknd 7546 9 b- b- NNP cord-010119-t1x9gknd 7546 10 ) ) -RRB- cord-010119-t1x9gknd 7546 11 , , , cord-010119-t1x9gknd 7546 12 Le(a1b1 Le(a1b1 NNP cord-010119-t1x9gknd 7546 13 ) ) -RRB- cord-010119-t1x9gknd 7546 14 and and CC cord-010119-t1x9gknd 7546 15 Lu(a Lu(a NNP cord-010119-t1x9gknd 7546 16 - - HYPH cord-010119-t1x9gknd 7546 17 b- b- NNP cord-010119-t1x9gknd 7546 18 ) ) -RRB- cord-010119-t1x9gknd 7546 19 were be VBD cord-010119-t1x9gknd 7546 20 0.3 0.3 CD cord-010119-t1x9gknd 7546 21 % % NN cord-010119-t1x9gknd 7546 22 , , , cord-010119-t1x9gknd 7546 23 0.3 0.3 CD cord-010119-t1x9gknd 7546 24 % % NN cord-010119-t1x9gknd 7546 25 and and CC cord-010119-t1x9gknd 7546 26 2.7 2.7 CD cord-010119-t1x9gknd 7546 27 % % NN cord-010119-t1x9gknd 7546 28 respectively respectively RB cord-010119-t1x9gknd 7546 29 , , , cord-010119-t1x9gknd 7546 30 while while IN cord-010119-t1x9gknd 7546 31 the the DT cord-010119-t1x9gknd 7546 32 M1N M1N NNP cord-010119-t1x9gknd 7546 33 - - HYPH cord-010119-t1x9gknd 7546 34 S S NNP cord-010119-t1x9gknd 7546 35 - - HYPH cord-010119-t1x9gknd 7546 36 s s POS cord-010119-t1x9gknd 7546 37 - - : cord-010119-t1x9gknd 7546 38 and and CC cord-010119-t1x9gknd 7546 39 M M NNP cord-010119-t1x9gknd 7546 40 - - HYPH cord-010119-t1x9gknd 7546 41 N1S N1S NNP cord-010119-t1x9gknd 7546 42 - - HYPH cord-010119-t1x9gknd 7546 43 s s NN cord-010119-t1x9gknd 7546 44 - - HYPH cord-010119-t1x9gknd 7546 45 phenotypes phenotype NNS cord-010119-t1x9gknd 7546 46 were be VBD cord-010119-t1x9gknd 7546 47 not not RB cord-010119-t1x9gknd 7546 48 found find VBN cord-010119-t1x9gknd 7546 49 . . . cord-010119-t1x9gknd 7547 1 The the DT cord-010119-t1x9gknd 7547 2 frequency frequency NN cord-010119-t1x9gknd 7547 3 of of IN cord-010119-t1x9gknd 7547 4 the the DT cord-010119-t1x9gknd 7547 5 P1 P1 NNP cord-010119-t1x9gknd 7547 6 antigen antigen NN cord-010119-t1x9gknd 7547 7 was be VBD cord-010119-t1x9gknd 7547 8 found find VBN cord-010119-t1x9gknd 7547 9 to to TO cord-010119-t1x9gknd 7547 10 be be VB cord-010119-t1x9gknd 7547 11 at at IN cord-010119-t1x9gknd 7547 12 78.9 78.9 CD cord-010119-t1x9gknd 7547 13 % % NN cord-010119-t1x9gknd 7547 14 similar similar JJ cord-010119-t1x9gknd 7547 15 to to IN cord-010119-t1x9gknd 7547 16 what what WP cord-010119-t1x9gknd 7547 17 has have VBZ cord-010119-t1x9gknd 7547 18 been be VBN cord-010119-t1x9gknd 7547 19 reported report VBN cord-010119-t1x9gknd 7547 20 in in IN cord-010119-t1x9gknd 7547 21 Caucasians Caucasians NNPS cord-010119-t1x9gknd 7547 22 . . . cord-010119-t1x9gknd 7548 1 Conclusion conclusion NN cord-010119-t1x9gknd 7548 2 : : : cord-010119-t1x9gknd 7549 1 This this DT cord-010119-t1x9gknd 7549 2 is be VBZ cord-010119-t1x9gknd 7549 3 the the DT cord-010119-t1x9gknd 7549 4 first first JJ cord-010119-t1x9gknd 7549 5 study study NN cord-010119-t1x9gknd 7549 6 to to TO cord-010119-t1x9gknd 7549 7 examine examine VB cord-010119-t1x9gknd 7549 8 the the DT cord-010119-t1x9gknd 7549 9 frequencies frequency NNS cord-010119-t1x9gknd 7549 10 of of IN cord-010119-t1x9gknd 7549 11 RBC RBC NNP cord-010119-t1x9gknd 7549 12 blood blood NN cord-010119-t1x9gknd 7549 13 group group NN cord-010119-t1x9gknd 7549 14 phenotypes phenotype NNS cord-010119-t1x9gknd 7549 15 among among IN cord-010119-t1x9gknd 7549 16 the the DT cord-010119-t1x9gknd 7549 17 Omani omani JJ cord-010119-t1x9gknd 7549 18 blood blood NN cord-010119-t1x9gknd 7549 19 donors donor NNS cord-010119-t1x9gknd 7549 20 . . . cord-010119-t1x9gknd 7550 1 The the DT cord-010119-t1x9gknd 7550 2 results result NNS cord-010119-t1x9gknd 7550 3 show show VBP cord-010119-t1x9gknd 7550 4 higher high JJR cord-010119-t1x9gknd 7550 5 frequencies frequency NNS cord-010119-t1x9gknd 7550 6 of of IN cord-010119-t1x9gknd 7550 7 the the DT cord-010119-t1x9gknd 7550 8 rare rare JJ cord-010119-t1x9gknd 7550 9 null null NN cord-010119-t1x9gknd 7550 10 phenotypes phenotype NNS cord-010119-t1x9gknd 7550 11 Fy(a Fy(a NNP cord-010119-t1x9gknd 7550 12 - - HYPH cord-010119-t1x9gknd 7550 13 b- b- NNP cord-010119-t1x9gknd 7550 14 ) ) -RRB- cord-010119-t1x9gknd 7551 1 , , , cord-010119-t1x9gknd 7551 2 Jk(a Jk(a NNP cord-010119-t1x9gknd 7551 3 - - HYPH cord-010119-t1x9gknd 7551 4 b- b- NNP cord-010119-t1x9gknd 7551 5 ) ) -RRB- cord-010119-t1x9gknd 7551 6 and and CC cord-010119-t1x9gknd 7551 7 Lu(a Lu(a NNP cord-010119-t1x9gknd 7551 8 - - HYPH cord-010119-t1x9gknd 7551 9 b- b- NNP cord-010119-t1x9gknd 7551 10 ) ) -RRB- cord-010119-t1x9gknd 7552 1 compared compare VBN cord-010119-t1x9gknd 7552 2 to to IN cord-010119-t1x9gknd 7552 3 what what WP cord-010119-t1x9gknd 7552 4 has have VBZ cord-010119-t1x9gknd 7552 5 been be VBN cord-010119-t1x9gknd 7552 6 reported report VBN cord-010119-t1x9gknd 7552 7 in in IN cord-010119-t1x9gknd 7552 8 Caucasians Caucasians NNPS cord-010119-t1x9gknd 7552 9 . . . cord-010119-t1x9gknd 7553 1 The the DT cord-010119-t1x9gknd 7553 2 frequencies frequency NNS cord-010119-t1x9gknd 7553 3 of of IN cord-010119-t1x9gknd 7553 4 the the DT cord-010119-t1x9gknd 7553 5 Duffy Duffy NNP cord-010119-t1x9gknd 7553 6 blood blood NN cord-010119-t1x9gknd 7553 7 group group NN cord-010119-t1x9gknd 7553 8 system system NN cord-010119-t1x9gknd 7553 9 resemble resemble VBP cord-010119-t1x9gknd 7553 10 what what WP cord-010119-t1x9gknd 7553 11 has have VBZ cord-010119-t1x9gknd 7553 12 been be VBN cord-010119-t1x9gknd 7553 13 reported report VBN cord-010119-t1x9gknd 7553 14 in in IN cord-010119-t1x9gknd 7553 15 the the DT cord-010119-t1x9gknd 7553 16 black black JJ cord-010119-t1x9gknd 7553 17 population population NN cord-010119-t1x9gknd 7553 18 . . . cord-010119-t1x9gknd 7554 1 This this DT cord-010119-t1x9gknd 7554 2 data data NN cord-010119-t1x9gknd 7554 3 is be VBZ cord-010119-t1x9gknd 7554 4 helpful helpful JJ cord-010119-t1x9gknd 7554 5 in in IN cord-010119-t1x9gknd 7554 6 understanding understand VBG cord-010119-t1x9gknd 7554 7 the the DT cord-010119-t1x9gknd 7554 8 influence influence NN cord-010119-t1x9gknd 7554 9 of of IN cord-010119-t1x9gknd 7554 10 the the DT cord-010119-t1x9gknd 7554 11 Arab arab JJ cord-010119-t1x9gknd 7554 12 ethnic ethnic JJ cord-010119-t1x9gknd 7554 13 background background NN cord-010119-t1x9gknd 7554 14 on on IN cord-010119-t1x9gknd 7554 15 the the DT cord-010119-t1x9gknd 7554 16 RBC RBC NNP cord-010119-t1x9gknd 7554 17 blood blood NN cord-010119-t1x9gknd 7554 18 group group NN cord-010119-t1x9gknd 7554 19 systems system NNS cord-010119-t1x9gknd 7554 20 and and CC cord-010119-t1x9gknd 7554 21 warrants warrant VBZ cord-010119-t1x9gknd 7554 22 large large JJ cord-010119-t1x9gknd 7554 23 genotype genotype NN cord-010119-t1x9gknd 7554 24 - - HYPH cord-010119-t1x9gknd 7554 25 phenotype phenotype NN cord-010119-t1x9gknd 7554 26 studies study NNS cord-010119-t1x9gknd 7554 27 in in IN cord-010119-t1x9gknd 7554 28 the the DT cord-010119-t1x9gknd 7554 29 region region NN cord-010119-t1x9gknd 7554 30 . . . cord-010119-t1x9gknd 7555 1 Quantitation Quantitation NNP cord-010119-t1x9gknd 7555 2 of of IN cord-010119-t1x9gknd 7555 3 Anti Anti NNP cord-010119-t1x9gknd 7555 4 - - NNP cord-010119-t1x9gknd 7555 5 D D NNP cord-010119-t1x9gknd 7555 6 in in IN cord-010119-t1x9gknd 7555 7 Serum serum NN cord-010119-t1x9gknd 7555 8 Using use VBG cord-010119-t1x9gknd 7555 9 Flow flow NN cord-010119-t1x9gknd 7555 10 Cytometry Cytometry NNP cord-010119-t1x9gknd 7555 11 Amanda Amanda NNP cord-010119-t1x9gknd 7555 12 Whitelonis Whitelonis NNP cord-010119-t1x9gknd 7556 1 * * NFP cord-010119-t1x9gknd 7556 2 , , , cord-010119-t1x9gknd 7556 3 Izekial Izekial NNP cord-010119-t1x9gknd 7556 4 Butler Butler NNP cord-010119-t1x9gknd 7556 5 , , , cord-010119-t1x9gknd 7556 6 Karen Karen NNP cord-010119-t1x9gknd 7556 7 Leighton Leighton NNP cord-010119-t1x9gknd 7556 8 , , , cord-010119-t1x9gknd 7556 9 Scott Scott NNP cord-010119-t1x9gknd 7556 10 Jones Jones NNP cord-010119-t1x9gknd 7556 11 and and CC cord-010119-t1x9gknd 7556 12 Anand Anand NNP cord-010119-t1x9gknd 7556 13 Srinivasan Srinivasan NNP cord-010119-t1x9gknd 7556 14 . . . cord-010119-t1x9gknd 7557 1 QualTex QualTex NNP cord-010119-t1x9gknd 7557 2 Laboratories Laboratories NNPS cord-010119-t1x9gknd 7557 3 Background Background NNP cord-010119-t1x9gknd 7557 4 / / SYM cord-010119-t1x9gknd 7557 5 Case Case NNP cord-010119-t1x9gknd 7557 6 Studies Studies NNPS cord-010119-t1x9gknd 7557 7 : : : cord-010119-t1x9gknd 7557 8 Rh(D Rh(D NNP cord-010119-t1x9gknd 7557 9 ) ) -RRB- cord-010119-t1x9gknd 7557 10 antibodies antibody NNS cord-010119-t1x9gknd 7557 11 ( ( -LRB- cord-010119-t1x9gknd 7557 12 anti anti JJ cord-010119-t1x9gknd 7557 13 - - JJ cord-010119-t1x9gknd 7557 14 D d JJ cord-010119-t1x9gknd 7557 15 ) ) -RRB- cord-010119-t1x9gknd 7557 16 are be VBP cord-010119-t1x9gknd 7557 17 developed develop VBN cord-010119-t1x9gknd 7557 18 in in IN cord-010119-t1x9gknd 7557 19 Rhnegative Rhnegative NNP cord-010119-t1x9gknd 7557 20 individuals individual NNS cord-010119-t1x9gknd 7557 21 when when WRB cord-010119-t1x9gknd 7557 22 exposed expose VBN cord-010119-t1x9gknd 7557 23 to to IN cord-010119-t1x9gknd 7557 24 D d NN cord-010119-t1x9gknd 7557 25 antigens antigen NNS cord-010119-t1x9gknd 7557 26 . . . cord-010119-t1x9gknd 7558 1 This this DT cord-010119-t1x9gknd 7558 2 scenario scenario NN cord-010119-t1x9gknd 7558 3 is be VBZ cord-010119-t1x9gknd 7558 4 commonly commonly RB cord-010119-t1x9gknd 7558 5 observed observe VBN cord-010119-t1x9gknd 7558 6 in in IN cord-010119-t1x9gknd 7558 7 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 7558 8 antenatal antenatal JJ cord-010119-t1x9gknd 7558 9 and and CC cord-010119-t1x9gknd 7558 10 volunteer volunteer NN cord-010119-t1x9gknd 7558 11 immunized immunize VBN cord-010119-t1x9gknd 7558 12 patients patient NNS cord-010119-t1x9gknd 7558 13 . . . cord-010119-t1x9gknd 7559 1 Quantitation quantitation NN cord-010119-t1x9gknd 7559 2 of of IN cord-010119-t1x9gknd 7559 3 anti anti JJ cord-010119-t1x9gknd 7559 4 - - JJ cord-010119-t1x9gknd 7559 5 D d JJ cord-010119-t1x9gknd 7559 6 in in IN cord-010119-t1x9gknd 7559 7 serum serum NN cord-010119-t1x9gknd 7559 8 is be VBZ cord-010119-t1x9gknd 7559 9 important important JJ cord-010119-t1x9gknd 7559 10 in in IN cord-010119-t1x9gknd 7559 11 the the DT cord-010119-t1x9gknd 7559 12 clinical clinical JJ cord-010119-t1x9gknd 7559 13 setting setting NN cord-010119-t1x9gknd 7559 14 to to TO cord-010119-t1x9gknd 7559 15 predict predict VB cord-010119-t1x9gknd 7559 16 the the DT cord-010119-t1x9gknd 7559 17 risk risk NN cord-010119-t1x9gknd 7559 18 of of IN cord-010119-t1x9gknd 7559 19 hemolytic hemolytic JJ cord-010119-t1x9gknd 7559 20 disease disease NN cord-010119-t1x9gknd 7559 21 of of IN cord-010119-t1x9gknd 7559 22 the the DT cord-010119-t1x9gknd 7559 23 newborn newborn NN cord-010119-t1x9gknd 7559 24 . . . cord-010119-t1x9gknd 7560 1 Quantitation quantitation NN cord-010119-t1x9gknd 7560 2 of of IN cord-010119-t1x9gknd 7560 3 anti anti JJ cord-010119-t1x9gknd 7560 4 - - JJ cord-010119-t1x9gknd 7560 5 D d JJ cord-010119-t1x9gknd 7560 6 is be VBZ cord-010119-t1x9gknd 7560 7 also also RB cord-010119-t1x9gknd 7560 8 performed perform VBN cord-010119-t1x9gknd 7560 9 in in IN cord-010119-t1x9gknd 7560 10 quality quality NN cord-010119-t1x9gknd 7560 11 control control NN cord-010119-t1x9gknd 7560 12 operations operation NNS cord-010119-t1x9gknd 7560 13 of of IN cord-010119-t1x9gknd 7560 14 organ organ NN cord-010119-t1x9gknd 7560 15 procurement procurement NN cord-010119-t1x9gknd 7560 16 organizations organization NNS cord-010119-t1x9gknd 7560 17 and and CC cord-010119-t1x9gknd 7560 18 plasma plasma NN cord-010119-t1x9gknd 7560 19 fractionators fractionator NNS cord-010119-t1x9gknd 7560 20 . . . cord-010119-t1x9gknd 7561 1 It -PRON- PRP cord-010119-t1x9gknd 7561 2 is be VBZ cord-010119-t1x9gknd 7561 3 a a DT cord-010119-t1x9gknd 7561 4 common common JJ cord-010119-t1x9gknd 7561 5 practice practice NN cord-010119-t1x9gknd 7561 6 to to TO cord-010119-t1x9gknd 7561 7 report report VB cord-010119-t1x9gknd 7561 8 the the DT cord-010119-t1x9gknd 7561 9 strength strength NN cord-010119-t1x9gknd 7561 10 of of IN cord-010119-t1x9gknd 7561 11 anti anti JJ cord-010119-t1x9gknd 7561 12 - - JJ cord-010119-t1x9gknd 7561 13 D d JJ cord-010119-t1x9gknd 7561 14 in in IN cord-010119-t1x9gknd 7561 15 serum serum NN cord-010119-t1x9gknd 7561 16 as as IN cord-010119-t1x9gknd 7561 17 antibody antibody NN cord-010119-t1x9gknd 7561 18 titer titer NN cord-010119-t1x9gknd 7561 19 values value NNS cord-010119-t1x9gknd 7561 20 but but CC cord-010119-t1x9gknd 7561 21 quality quality NN cord-010119-t1x9gknd 7561 22 control control NN cord-010119-t1x9gknd 7561 23 operations operation NNS cord-010119-t1x9gknd 7561 24 require require VBP cord-010119-t1x9gknd 7561 25 a a DT cord-010119-t1x9gknd 7561 26 quantitative quantitative JJ cord-010119-t1x9gknd 7561 27 value value NN cord-010119-t1x9gknd 7561 28 . . . cord-010119-t1x9gknd 7562 1 We -PRON- PRP cord-010119-t1x9gknd 7562 2 have have VBP cord-010119-t1x9gknd 7562 3 developed develop VBN cord-010119-t1x9gknd 7562 4 a a DT cord-010119-t1x9gknd 7562 5 screening screening NN cord-010119-t1x9gknd 7562 6 assay assay NN cord-010119-t1x9gknd 7562 7 using use VBG cord-010119-t1x9gknd 7562 8 flow flow NN cord-010119-t1x9gknd 7562 9 cytometry cytometry NN cord-010119-t1x9gknd 7562 10 to to TO cord-010119-t1x9gknd 7562 11 quantitate quantitate VB cord-010119-t1x9gknd 7562 12 anti anti JJ cord-010119-t1x9gknd 7562 13 - - JJ cord-010119-t1x9gknd 7562 14 D d JJ cord-010119-t1x9gknd 7562 15 in in IN cord-010119-t1x9gknd 7562 16 serum serum NN cord-010119-t1x9gknd 7562 17 . . . cord-010119-t1x9gknd 7563 1 Study Study NNP cord-010119-t1x9gknd 7563 2 Design Design NNP cord-010119-t1x9gknd 7563 3 / / SYM cord-010119-t1x9gknd 7563 4 Method method NN cord-010119-t1x9gknd 7563 5 : : : cord-010119-t1x9gknd 7563 6 We -PRON- PRP cord-010119-t1x9gknd 7563 7 have have VBP cord-010119-t1x9gknd 7563 8 developed develop VBN cord-010119-t1x9gknd 7563 9 a a DT cord-010119-t1x9gknd 7563 10 method method NN cord-010119-t1x9gknd 7563 11 to to TO cord-010119-t1x9gknd 7563 12 quantitate quantitate VB cord-010119-t1x9gknd 7563 13 anti anti JJ cord-010119-t1x9gknd 7563 14 - - JJ cord-010119-t1x9gknd 7563 15 D d JJ cord-010119-t1x9gknd 7563 16 in in IN cord-010119-t1x9gknd 7563 17 serum serum NN cord-010119-t1x9gknd 7563 18 using use VBG cord-010119-t1x9gknd 7563 19 flow flow NN cord-010119-t1x9gknd 7563 20 cytometry cytometry NN cord-010119-t1x9gknd 7563 21 , , , cord-010119-t1x9gknd 7563 22 by by IN cord-010119-t1x9gknd 7563 23 modifying modify VBG cord-010119-t1x9gknd 7563 24 the the DT cord-010119-t1x9gknd 7563 25 protocols protocol NNS cord-010119-t1x9gknd 7563 26 of of IN cord-010119-t1x9gknd 7563 27 Christensson Christensson NNP cord-010119-t1x9gknd 7563 28 et et NNP cord-010119-t1x9gknd 7563 29 al al NNP cord-010119-t1x9gknd 7563 30 . . NNP cord-010119-t1x9gknd 7563 31 , , , cord-010119-t1x9gknd 7563 32 and and CC cord-010119-t1x9gknd 7564 1 Hilden Hilden NNP cord-010119-t1x9gknd 7564 2 et et NNP cord-010119-t1x9gknd 7564 3 al al NNP cord-010119-t1x9gknd 7564 4 .. .. . cord-010119-t1x9gknd 7565 1 Red red JJ cord-010119-t1x9gknd 7565 2 blood blood NN cord-010119-t1x9gknd 7565 3 cells cell NNS cord-010119-t1x9gknd 7565 4 from from IN cord-010119-t1x9gknd 7565 5 Rh Rh NNP cord-010119-t1x9gknd 7565 6 - - HYPH cord-010119-t1x9gknd 7565 7 positive positive JJ cord-010119-t1x9gknd 7565 8 blood blood NN cord-010119-t1x9gknd 7565 9 samples sample NNS cord-010119-t1x9gknd 7565 10 were be VBD cord-010119-t1x9gknd 7565 11 washed wash VBN cord-010119-t1x9gknd 7565 12 three three CD cord-010119-t1x9gknd 7565 13 times time NNS cord-010119-t1x9gknd 7565 14 in in IN cord-010119-t1x9gknd 7565 15 phosphate phosphate NN cord-010119-t1x9gknd 7565 16 - - HYPH cord-010119-t1x9gknd 7565 17 buffered buffer VBN cord-010119-t1x9gknd 7565 18 saline saline NN cord-010119-t1x9gknd 7565 19 ( ( -LRB- cord-010119-t1x9gknd 7565 20 PBS PBS NNP cord-010119-t1x9gknd 7565 21 ) ) -RRB- cord-010119-t1x9gknd 7565 22 at at IN cord-010119-t1x9gknd 7565 23 pH pH NNP cord-010119-t1x9gknd 7565 24 7.2 7.2 CD cord-010119-t1x9gknd 7565 25 and and CC cord-010119-t1x9gknd 7565 26 the the DT cord-010119-t1x9gknd 7565 27 supernatant supernatant NN cord-010119-t1x9gknd 7565 28 was be VBD cord-010119-t1x9gknd 7565 29 discharged discharge VBN cord-010119-t1x9gknd 7565 30 . . . cord-010119-t1x9gknd 7566 1 A a DT cord-010119-t1x9gknd 7566 2 dilution dilution NN cord-010119-t1x9gknd 7566 3 buffer buffer NN cord-010119-t1x9gknd 7566 4 containing contain VBG cord-010119-t1x9gknd 7566 5 2 2 CD cord-010119-t1x9gknd 7566 6 % % NN cord-010119-t1x9gknd 7566 7 human human JJ cord-010119-t1x9gknd 7566 8 serum serum NN cord-010119-t1x9gknd 7566 9 albumin albumin NN cord-010119-t1x9gknd 7566 10 ( ( -LRB- cord-010119-t1x9gknd 7566 11 v v NN cord-010119-t1x9gknd 7566 12 / / SYM cord-010119-t1x9gknd 7566 13 v v NN cord-010119-t1x9gknd 7566 14 ) ) -RRB- cord-010119-t1x9gknd 7566 15 in in IN cord-010119-t1x9gknd 7566 16 phosphate phosphate NN cord-010119-t1x9gknd 7566 17 buffered buffer VBN cord-010119-t1x9gknd 7566 18 saline saline NN cord-010119-t1x9gknd 7566 19 was be VBD cord-010119-t1x9gknd 7566 20 prepared prepare VBN cord-010119-t1x9gknd 7566 21 . . . cord-010119-t1x9gknd 7567 1 Serum serum NN cord-010119-t1x9gknd 7567 2 samples sample NNS cord-010119-t1x9gknd 7567 3 or or CC cord-010119-t1x9gknd 7567 4 WHO who WP cord-010119-t1x9gknd 7567 5 anti anti JJ cord-010119-t1x9gknd 7567 6 - - JJ cord-010119-t1x9gknd 7567 7 D d JJ cord-010119-t1x9gknd 7567 8 standards standard NNS cord-010119-t1x9gknd 7567 9 , , , cord-010119-t1x9gknd 7567 10 suspended suspend VBN cord-010119-t1x9gknd 7567 11 in in IN cord-010119-t1x9gknd 7567 12 dilution dilution NN cord-010119-t1x9gknd 7567 13 buffer buffer NN cord-010119-t1x9gknd 7567 14 were be VBD cord-010119-t1x9gknd 7567 15 mixed mix VBN cord-010119-t1x9gknd 7567 16 with with IN cord-010119-t1x9gknd 7567 17 10ll 10ll CD cord-010119-t1x9gknd 7567 18 of of IN cord-010119-t1x9gknd 7567 19 washed wash VBN cord-010119-t1x9gknd 7567 20 red red JJ cord-010119-t1x9gknd 7567 21 cells cell NNS cord-010119-t1x9gknd 7567 22 . . . cord-010119-t1x9gknd 7568 1 The the DT cord-010119-t1x9gknd 7568 2 cell cell NN cord-010119-t1x9gknd 7568 3 suspensions suspension NNS cord-010119-t1x9gknd 7568 4 were be VBD cord-010119-t1x9gknd 7568 5 incubated incubate VBN cord-010119-t1x9gknd 7568 6 for for IN cord-010119-t1x9gknd 7568 7 30 30 CD cord-010119-t1x9gknd 7568 8 min min NN cord-010119-t1x9gknd 7568 9 at at IN cord-010119-t1x9gknd 7568 10 378C. 378c. NN cord-010119-t1x9gknd 7568 11 Following follow VBG cord-010119-t1x9gknd 7568 12 incubation incubation NN cord-010119-t1x9gknd 7568 13 , , , cord-010119-t1x9gknd 7568 14 FITC FITC NNP cord-010119-t1x9gknd 7568 15 - - HYPH cord-010119-t1x9gknd 7568 16 labeled label VBN cord-010119-t1x9gknd 7568 17 anti anti JJ cord-010119-t1x9gknd 7568 18 - - JJ cord-010119-t1x9gknd 7568 19 IgG igg JJ cord-010119-t1x9gknd 7568 20 diluted dilute VBN cord-010119-t1x9gknd 7568 21 in in IN cord-010119-t1x9gknd 7568 22 buffer buffer NN cord-010119-t1x9gknd 7568 23 was be VBD cord-010119-t1x9gknd 7568 24 added add VBN cord-010119-t1x9gknd 7568 25 and and CC cord-010119-t1x9gknd 7568 26 the the DT cord-010119-t1x9gknd 7568 27 mixture mixture NN cord-010119-t1x9gknd 7568 28 was be VBD cord-010119-t1x9gknd 7568 29 incubated incubate VBN cord-010119-t1x9gknd 7568 30 for for IN cord-010119-t1x9gknd 7568 31 an an DT cord-010119-t1x9gknd 7568 32 additional additional JJ cord-010119-t1x9gknd 7568 33 15 15 CD cord-010119-t1x9gknd 7568 34 min min NN cord-010119-t1x9gknd 7568 35 at at IN cord-010119-t1x9gknd 7568 36 228C. 228c. CD cord-010119-t1x9gknd 7569 1 The the DT cord-010119-t1x9gknd 7569 2 samples sample NNS cord-010119-t1x9gknd 7569 3 were be VBD cord-010119-t1x9gknd 7569 4 then then RB cord-010119-t1x9gknd 7569 5 analyzed analyze VBN cord-010119-t1x9gknd 7569 6 by by IN cord-010119-t1x9gknd 7569 7 flow flow NN cord-010119-t1x9gknd 7569 8 cytometry cytometry NN cord-010119-t1x9gknd 7569 9 using use VBG cord-010119-t1x9gknd 7569 10 gates gate NNS cord-010119-t1x9gknd 7569 11 for for IN cord-010119-t1x9gknd 7569 12 a a DT cord-010119-t1x9gknd 7569 13 typical typical JJ cord-010119-t1x9gknd 7569 14 red red JJ cord-010119-t1x9gknd 7569 15 cell cell NN cord-010119-t1x9gknd 7569 16 based base VBN cord-010119-t1x9gknd 7569 17 on on IN cord-010119-t1x9gknd 7569 18 the the DT cord-010119-t1x9gknd 7569 19 forward forward NN cord-010119-t1x9gknd 7569 20 and and CC cord-010119-t1x9gknd 7569 21 side side NN cord-010119-t1x9gknd 7569 22 - - HYPH cord-010119-t1x9gknd 7569 23 scatter scatter NN cord-010119-t1x9gknd 7569 24 signals signal NNS cord-010119-t1x9gknd 7569 25 . . . cord-010119-t1x9gknd 7570 1 Green green JJ cord-010119-t1x9gknd 7570 2 fluorescence fluorescence NN cord-010119-t1x9gknd 7570 3 was be VBD cord-010119-t1x9gknd 7570 4 collected collect VBN cord-010119-t1x9gknd 7570 5 using use VBG cord-010119-t1x9gknd 7570 6 a a DT cord-010119-t1x9gknd 7570 7 band band NN cord-010119-t1x9gknd 7570 8 - - HYPH cord-010119-t1x9gknd 7570 9 pass pass NN cord-010119-t1x9gknd 7570 10 filter filter NN cord-010119-t1x9gknd 7570 11 set set VBN cord-010119-t1x9gknd 7570 12 for for IN cord-010119-t1x9gknd 7570 13 515 515 CD cord-010119-t1x9gknd 7570 14 - - SYM cord-010119-t1x9gknd 7570 15 548 548 CD cord-010119-t1x9gknd 7570 16 nm nm NN cord-010119-t1x9gknd 7570 17 . . . cord-010119-t1x9gknd 7571 1 Events event NNS cord-010119-t1x9gknd 7571 2 were be VBD cord-010119-t1x9gknd 7571 3 recorded record VBN cord-010119-t1x9gknd 7571 4 at at IN cord-010119-t1x9gknd 7571 5 a a DT cord-010119-t1x9gknd 7571 6 frequency frequency NN cord-010119-t1x9gknd 7571 7 of of IN cord-010119-t1x9gknd 7571 8 1000 1000 CD cord-010119-t1x9gknd 7571 9 cells cell NNS cord-010119-t1x9gknd 7571 10 . . . cord-010119-t1x9gknd 7572 1 Results result NNS cord-010119-t1x9gknd 7572 2 / / SYM cord-010119-t1x9gknd 7572 3 Finding finding NN cord-010119-t1x9gknd 7572 4 : : : cord-010119-t1x9gknd 7572 5 Multiple multiple JJ cord-010119-t1x9gknd 7572 6 dilutions dilution NNS cord-010119-t1x9gknd 7572 7 of of IN cord-010119-t1x9gknd 7572 8 WHO who WP cord-010119-t1x9gknd 7572 9 anti anti JJ cord-010119-t1x9gknd 7572 10 - - JJ cord-010119-t1x9gknd 7572 11 D d JJ cord-010119-t1x9gknd 7572 12 reference reference NN cord-010119-t1x9gknd 7572 13 standard standard NN cord-010119-t1x9gknd 7572 14 were be VBD cord-010119-t1x9gknd 7572 15 tested test VBN cord-010119-t1x9gknd 7572 16 against against IN cord-010119-t1x9gknd 7572 17 Rh Rh NNP cord-010119-t1x9gknd 7572 18 - - HYPH cord-010119-t1x9gknd 7572 19 positive positive JJ cord-010119-t1x9gknd 7572 20 red red JJ cord-010119-t1x9gknd 7572 21 blood blood NN cord-010119-t1x9gknd 7572 22 cells cell NNS cord-010119-t1x9gknd 7572 23 from from IN cord-010119-t1x9gknd 7572 24 five five CD cord-010119-t1x9gknd 7572 25 different different JJ cord-010119-t1x9gknd 7572 26 donors donor NNS cord-010119-t1x9gknd 7572 27 . . . cord-010119-t1x9gknd 7573 1 The the DT cord-010119-t1x9gknd 7573 2 reproducibility reproducibility NN cord-010119-t1x9gknd 7573 3 of of IN cord-010119-t1x9gknd 7573 4 the the DT cord-010119-t1x9gknd 7573 5 assay assay NN cord-010119-t1x9gknd 7573 6 was be VBD cord-010119-t1x9gknd 7573 7 determined determine VBN cord-010119-t1x9gknd 7573 8 by by IN cord-010119-t1x9gknd 7573 9 measuring measure VBG cord-010119-t1x9gknd 7573 10 the the DT cord-010119-t1x9gknd 7573 11 change change NN cord-010119-t1x9gknd 7573 12 in in IN cord-010119-t1x9gknd 7573 13 coefficient coefficient NN cord-010119-t1x9gknd 7573 14 of of IN cord-010119-t1x9gknd 7573 15 variance variance NN cord-010119-t1x9gknd 7573 16 due due IN cord-010119-t1x9gknd 7573 17 to to IN cord-010119-t1x9gknd 7573 18 dilution dilution NN cord-010119-t1x9gknd 7573 19 procedure procedure NN cord-010119-t1x9gknd 7573 20 , , , cord-010119-t1x9gknd 7573 21 machine machine NN cord-010119-t1x9gknd 7573 22 variation variation NN cord-010119-t1x9gknd 7573 23 and and CC cord-010119-t1x9gknd 7573 24 sample sample NN cord-010119-t1x9gknd 7573 25 storage storage NN cord-010119-t1x9gknd 7573 26 condition condition NN cord-010119-t1x9gknd 7573 27 . . . cord-010119-t1x9gknd 7574 1 After after IN cord-010119-t1x9gknd 7574 2 optimizing optimize VBG cord-010119-t1x9gknd 7574 3 these these DT cord-010119-t1x9gknd 7574 4 factors factor NNS cord-010119-t1x9gknd 7574 5 , , , cord-010119-t1x9gknd 7574 6 a a DT cord-010119-t1x9gknd 7574 7 linear linear JJ cord-010119-t1x9gknd 7574 8 regression regression NN cord-010119-t1x9gknd 7574 9 was be VBD cord-010119-t1x9gknd 7574 10 calculated calculate VBN cord-010119-t1x9gknd 7574 11 to to TO cord-010119-t1x9gknd 7574 12 establish establish VB cord-010119-t1x9gknd 7574 13 the the DT cord-010119-t1x9gknd 7574 14 standard standard JJ cord-010119-t1x9gknd 7574 15 curve curve NN cord-010119-t1x9gknd 7574 16 . . . cord-010119-t1x9gknd 7575 1 The the DT cord-010119-t1x9gknd 7575 2 fluorescent fluorescent NN cord-010119-t1x9gknd 7575 3 intensity intensity NN cord-010119-t1x9gknd 7575 4 emitted emit VBN cord-010119-t1x9gknd 7575 5 by by IN cord-010119-t1x9gknd 7575 6 probes probe NNS cord-010119-t1x9gknd 7575 7 demonstrated demonstrate VBD cord-010119-t1x9gknd 7575 8 a a DT cord-010119-t1x9gknd 7575 9 linear linear JJ cord-010119-t1x9gknd 7575 10 correlation correlation NN cord-010119-t1x9gknd 7575 11 with with IN cord-010119-t1x9gknd 7575 12 the the DT cord-010119-t1x9gknd 7575 13 concentration concentration NN cord-010119-t1x9gknd 7575 14 of of IN cord-010119-t1x9gknd 7575 15 Rh(D Rh(D NNP cord-010119-t1x9gknd 7575 16 ) ) -RRB- cord-010119-t1x9gknd 7575 17 antigens antigen NNS cord-010119-t1x9gknd 7575 18 in in IN cord-010119-t1x9gknd 7575 19 reference reference NN cord-010119-t1x9gknd 7575 20 standard standard NN cord-010119-t1x9gknd 7575 21 . . . cord-010119-t1x9gknd 7576 1 Serum serum NN cord-010119-t1x9gknd 7576 2 from from IN cord-010119-t1x9gknd 7576 3 thirty thirty CD cord-010119-t1x9gknd 7576 4 Rh(D)-immunized rh(d)-immunized JJ cord-010119-t1x9gknd 7576 5 volunteers volunteer NNS cord-010119-t1x9gknd 7576 6 were be VBD cord-010119-t1x9gknd 7576 7 analyzed analyze VBN cord-010119-t1x9gknd 7576 8 for for IN cord-010119-t1x9gknd 7576 9 concentration concentration NN cord-010119-t1x9gknd 7576 10 of of IN cord-010119-t1x9gknd 7576 11 anti anti JJ cord-010119-t1x9gknd 7576 12 - - JJ cord-010119-t1x9gknd 7576 13 D d JJ cord-010119-t1x9gknd 7576 14 and and CC cord-010119-t1x9gknd 7576 15 the the DT cord-010119-t1x9gknd 7576 16 results result NNS cord-010119-t1x9gknd 7576 17 were be VBD cord-010119-t1x9gknd 7576 18 benchmarked benchmarke VBN cord-010119-t1x9gknd 7576 19 with with IN cord-010119-t1x9gknd 7576 20 antibody antibody NN cord-010119-t1x9gknd 7576 21 titer titer NN cord-010119-t1x9gknd 7576 22 values value NNS cord-010119-t1x9gknd 7576 23 . . . cord-010119-t1x9gknd 7577 1 Conclusion conclusion NN cord-010119-t1x9gknd 7577 2 : : : cord-010119-t1x9gknd 7578 1 Based base VBN cord-010119-t1x9gknd 7578 2 on on IN cord-010119-t1x9gknd 7578 3 our -PRON- PRP$ cord-010119-t1x9gknd 7578 4 study study NN cord-010119-t1x9gknd 7578 5 , , , cord-010119-t1x9gknd 7578 6 we -PRON- PRP cord-010119-t1x9gknd 7578 7 conclude conclude VBP cord-010119-t1x9gknd 7578 8 that that IN cord-010119-t1x9gknd 7578 9 the the DT cord-010119-t1x9gknd 7578 10 quantitation quantitation NN cord-010119-t1x9gknd 7578 11 of of IN cord-010119-t1x9gknd 7578 12 Rh Rh NNP cord-010119-t1x9gknd 7578 13 antigens antigen NNS cord-010119-t1x9gknd 7578 14 by by IN cord-010119-t1x9gknd 7578 15 flow flow NN cord-010119-t1x9gknd 7578 16 cytometry cytometry NN cord-010119-t1x9gknd 7578 17 can can MD cord-010119-t1x9gknd 7578 18 be be VB cord-010119-t1x9gknd 7578 19 used use VBN cord-010119-t1x9gknd 7578 20 as as IN cord-010119-t1x9gknd 7578 21 a a DT cord-010119-t1x9gknd 7578 22 reliable reliable JJ cord-010119-t1x9gknd 7578 23 assay assay NN cord-010119-t1x9gknd 7578 24 to to TO cord-010119-t1x9gknd 7578 25 measure measure VB cord-010119-t1x9gknd 7578 26 the the DT cord-010119-t1x9gknd 7578 27 concentration concentration NN cord-010119-t1x9gknd 7578 28 of of IN cord-010119-t1x9gknd 7578 29 anti anti JJ cord-010119-t1x9gknd 7578 30 - - JJ cord-010119-t1x9gknd 7578 31 D d JJ cord-010119-t1x9gknd 7578 32 antibodies antibody NNS cord-010119-t1x9gknd 7578 33 in in IN cord-010119-t1x9gknd 7578 34 serum serum NN cord-010119-t1x9gknd 7578 35 . . . cord-010119-t1x9gknd 7579 1 The the DT cord-010119-t1x9gknd 7579 2 method method NN cord-010119-t1x9gknd 7579 3 is be VBZ cord-010119-t1x9gknd 7579 4 reproducible reproducible JJ cord-010119-t1x9gknd 7579 5 and and CC cord-010119-t1x9gknd 7579 6 advantageous advantageous JJ cord-010119-t1x9gknd 7579 7 over over IN cord-010119-t1x9gknd 7579 8 reporting report VBG cord-010119-t1x9gknd 7579 9 antibody antibody NN cord-010119-t1x9gknd 7579 10 titer titer NN cord-010119-t1x9gknd 7579 11 values value NNS cord-010119-t1x9gknd 7579 12 . . . cord-010119-t1x9gknd 7580 1 The the DT cord-010119-t1x9gknd 7580 2 operations operation NNS cord-010119-t1x9gknd 7580 3 of of IN cord-010119-t1x9gknd 7580 4 this this DT cord-010119-t1x9gknd 7580 5 platform platform NN cord-010119-t1x9gknd 7580 6 can can MD cord-010119-t1x9gknd 7580 7 be be VB cord-010119-t1x9gknd 7580 8 translated translate VBN cord-010119-t1x9gknd 7580 9 to to IN cord-010119-t1x9gknd 7580 10 a a DT cord-010119-t1x9gknd 7580 11 well well JJ cord-010119-t1x9gknd 7580 12 - - HYPH cord-010119-t1x9gknd 7580 13 plate plate NN cord-010119-t1x9gknd 7580 14 based base VBN cord-010119-t1x9gknd 7580 15 high high JJ cord-010119-t1x9gknd 7580 16 - - HYPH cord-010119-t1x9gknd 7580 17 throughput throughput NN cord-010119-t1x9gknd 7580 18 flow flow NN cord-010119-t1x9gknd 7580 19 cytometry cytometry NN cord-010119-t1x9gknd 7580 20 . . . cord-010119-t1x9gknd 7581 1 Sarah Sarah NNP cord-010119-t1x9gknd 7581 2 K K NNP cord-010119-t1x9gknd 7581 3 Harm Harm NNP cord-010119-t1x9gknd 7581 4 * * NFP cord-010119-t1x9gknd 7581 5 1 1 CD cord-010119-t1x9gknd 7581 6 , , , cord-010119-t1x9gknd 7581 7 Mark Mark NNP cord-010119-t1x9gknd 7581 8 Yazer Yazer NNP cord-010119-t1x9gknd 7581 9 2 2 CD cord-010119-t1x9gknd 7581 10 , , , cord-010119-t1x9gknd 7581 11 Nancy Nancy NNP cord-010119-t1x9gknd 7581 12 M. M. NNP cord-010119-t1x9gknd 7581 13 Dunbar Dunbar NNP cord-010119-t1x9gknd 7581 14 3 3 CD cord-010119-t1x9gknd 7581 15 and and CC cord-010119-t1x9gknd 7581 16 Biomedical Biomedical NNP cord-010119-t1x9gknd 7581 17 Excellence Excellence NNP cord-010119-t1x9gknd 7581 18 for for IN cord-010119-t1x9gknd 7581 19 Safer Safer NNP cord-010119-t1x9gknd 7581 20 Transfusion Transfusion NNP cord-010119-t1x9gknd 7581 21 ( ( -LRB- cord-010119-t1x9gknd 7581 22 BEST BEST NNP cord-010119-t1x9gknd 7581 23 ) ) -RRB- cord-010119-t1x9gknd 7581 24 Collaborative collaborative NN cord-010119-t1x9gknd 7581 25 1 1 CD cord-010119-t1x9gknd 7581 26 . . . cord-010119-t1x9gknd 7582 1 1 1 CD cord-010119-t1x9gknd 7582 2 University University NNP cord-010119-t1x9gknd 7582 3 of of IN cord-010119-t1x9gknd 7582 4 Vermont Vermont NNP cord-010119-t1x9gknd 7582 5 Medical Medical NNP cord-010119-t1x9gknd 7582 6 Center Center NNP cord-010119-t1x9gknd 7582 7 , , , cord-010119-t1x9gknd 7582 8 2 2 CD cord-010119-t1x9gknd 7582 9 University University NNP cord-010119-t1x9gknd 7582 10 of of IN cord-010119-t1x9gknd 7582 11 Pittsburgh Pittsburgh NNP cord-010119-t1x9gknd 7582 12 , , , cord-010119-t1x9gknd 7582 13 3 3 CD cord-010119-t1x9gknd 7582 14 Dartmouth Dartmouth NNP cord-010119-t1x9gknd 7582 15 - - HYPH cord-010119-t1x9gknd 7582 16 Hitchcock Hitchcock NNP cord-010119-t1x9gknd 7582 17 Medical Medical NNP cord-010119-t1x9gknd 7582 18 Center Center NNP cord-010119-t1x9gknd 7582 19 Background Background NNP cord-010119-t1x9gknd 7582 20 / / SYM cord-010119-t1x9gknd 7582 21 Case Case NNP cord-010119-t1x9gknd 7582 22 Studies Studies NNPS cord-010119-t1x9gknd 7582 23 : : : cord-010119-t1x9gknd 7583 1 The the DT cord-010119-t1x9gknd 7583 2 use use NN cord-010119-t1x9gknd 7583 3 of of IN cord-010119-t1x9gknd 7583 4 emergency emergency NN cord-010119-t1x9gknd 7583 5 issued issue VBN cord-010119-t1x9gknd 7583 6 group group NN cord-010119-t1x9gknd 7584 1 A a DT cord-010119-t1x9gknd 7584 2 plasma plasma NN cord-010119-t1x9gknd 7584 3 and and CC cord-010119-t1x9gknd 7584 4 uncrossmatched uncrossmatched JJ cord-010119-t1x9gknd 7584 5 group group NN cord-010119-t1x9gknd 7584 6 O o NN cord-010119-t1x9gknd 7584 7 whole whole JJ cord-010119-t1x9gknd 7584 8 blood blood NN cord-010119-t1x9gknd 7584 9 ( ( -LRB- cord-010119-t1x9gknd 7584 10 WB WB NNP cord-010119-t1x9gknd 7584 11 ) ) -RRB- cord-010119-t1x9gknd 7584 12 in in IN cord-010119-t1x9gknd 7584 13 patients patient NNS cord-010119-t1x9gknd 7584 14 without without IN cord-010119-t1x9gknd 7584 15 a a DT cord-010119-t1x9gknd 7584 16 valid valid JJ cord-010119-t1x9gknd 7584 17 ABO ABO NNP cord-010119-t1x9gknd 7584 18 group group NN cord-010119-t1x9gknd 7584 19 is be VBZ cord-010119-t1x9gknd 7584 20 becoming become VBG cord-010119-t1x9gknd 7584 21 increasingly increasingly RB cord-010119-t1x9gknd 7584 22 common common JJ cord-010119-t1x9gknd 7584 23 in in IN cord-010119-t1x9gknd 7584 24 the the DT cord-010119-t1x9gknd 7584 25 USA USA NNP cord-010119-t1x9gknd 7584 26 . . . cord-010119-t1x9gknd 7585 1 It -PRON- PRP cord-010119-t1x9gknd 7585 2 is be VBZ cord-010119-t1x9gknd 7585 3 unclear unclear JJ cord-010119-t1x9gknd 7585 4 if if IN cord-010119-t1x9gknd 7585 5 low low JJ cord-010119-t1x9gknd 7585 6 titer titer NN cord-010119-t1x9gknd 7585 7 products product NNS cord-010119-t1x9gknd 7585 8 should should MD cord-010119-t1x9gknd 7585 9 be be VB cord-010119-t1x9gknd 7585 10 provided provide VBN cord-010119-t1x9gknd 7585 11 in in IN cord-010119-t1x9gknd 7585 12 this this DT cord-010119-t1x9gknd 7585 13 situation situation NN cord-010119-t1x9gknd 7585 14 and and CC cord-010119-t1x9gknd 7585 15 indeed indeed RB cord-010119-t1x9gknd 7585 16 a a DT cord-010119-t1x9gknd 7585 17 universally universally RB cord-010119-t1x9gknd 7585 18 agreed agree VBN cord-010119-t1x9gknd 7585 19 upon upon IN cord-010119-t1x9gknd 7585 20 threshold threshold NN cord-010119-t1x9gknd 7585 21 that that WDT cord-010119-t1x9gknd 7585 22 would would MD cord-010119-t1x9gknd 7585 23 qualify qualify VB cord-010119-t1x9gknd 7585 24 as as IN cord-010119-t1x9gknd 7585 25 " " `` cord-010119-t1x9gknd 7585 26 low low JJ cord-010119-t1x9gknd 7585 27 titer titer NN cord-010119-t1x9gknd 7585 28 " " '' cord-010119-t1x9gknd 7585 29 has have VBZ cord-010119-t1x9gknd 7585 30 not not RB cord-010119-t1x9gknd 7585 31 been be VBN cord-010119-t1x9gknd 7585 32 established establish VBN cord-010119-t1x9gknd 7585 33 . . . cord-010119-t1x9gknd 7586 1 This this DT cord-010119-t1x9gknd 7586 2 study study NN cord-010119-t1x9gknd 7586 3 was be VBD cord-010119-t1x9gknd 7586 4 designed design VBN cord-010119-t1x9gknd 7586 5 to to TO cord-010119-t1x9gknd 7586 6 determine determine VB cord-010119-t1x9gknd 7586 7 the the DT cord-010119-t1x9gknd 7586 8 rate rate NN cord-010119-t1x9gknd 7586 9 of of IN cord-010119-t1x9gknd 7586 10 high high JJ cord-010119-t1x9gknd 7586 11 titer titer NN cord-010119-t1x9gknd 7586 12 donors donor NNS cord-010119-t1x9gknd 7586 13 using use VBG cord-010119-t1x9gknd 7586 14 a a DT cord-010119-t1x9gknd 7586 15 titer titer NN cord-010119-t1x9gknd 7586 16 threshold threshold NN cord-010119-t1x9gknd 7586 17 of of IN cord-010119-t1x9gknd 7586 18 50 50 CD cord-010119-t1x9gknd 7586 19 . . . cord-010119-t1x9gknd 7587 1 Study Study NNP cord-010119-t1x9gknd 7587 2 Design Design NNP cord-010119-t1x9gknd 7587 3 / / SYM cord-010119-t1x9gknd 7587 4 Methods method NNS cord-010119-t1x9gknd 7587 5 : : : cord-010119-t1x9gknd 7588 1 Three three CD cord-010119-t1x9gknd 7588 2 academic academic JJ cord-010119-t1x9gknd 7588 3 hospitals hospital NNS cord-010119-t1x9gknd 7588 4 that that WDT cord-010119-t1x9gknd 7588 5 routinely routinely RB cord-010119-t1x9gknd 7588 6 issue issue VBP cord-010119-t1x9gknd 7588 7 group group NN cord-010119-t1x9gknd 7588 8 A a DT cord-010119-t1x9gknd 7588 9 plasma plasma NN cord-010119-t1x9gknd 7588 10 units unit NNS cord-010119-t1x9gknd 7588 11 for for IN cord-010119-t1x9gknd 7588 12 emergency emergency NN cord-010119-t1x9gknd 7588 13 issue issue NN cord-010119-t1x9gknd 7588 14 participated participate VBD cord-010119-t1x9gknd 7588 15 in in IN cord-010119-t1x9gknd 7588 16 this this DT cord-010119-t1x9gknd 7588 17 study study NN cord-010119-t1x9gknd 7588 18 . . . cord-010119-t1x9gknd 7589 1 Before before IN cord-010119-t1x9gknd 7589 2 issuing issue VBG cord-010119-t1x9gknd 7589 3 this this DT cord-010119-t1x9gknd 7589 4 plasma plasma NN cord-010119-t1x9gknd 7589 5 to to IN cord-010119-t1x9gknd 7589 6 patients patient NNS cord-010119-t1x9gknd 7589 7 , , , cord-010119-t1x9gknd 7589 8 a a DT cord-010119-t1x9gknd 7589 9 1:50 1:50 CD cord-010119-t1x9gknd 7589 10 dilution dilution NN cord-010119-t1x9gknd 7589 11 of of IN cord-010119-t1x9gknd 7589 12 the the DT cord-010119-t1x9gknd 7589 13 donor donor NN cord-010119-t1x9gknd 7589 14 's 's POS cord-010119-t1x9gknd 7589 15 plasma plasma NN cord-010119-t1x9gknd 7589 16 in in IN cord-010119-t1x9gknd 7589 17 saline saline NN cord-010119-t1x9gknd 7589 18 was be VBD cord-010119-t1x9gknd 7589 19 produced produce VBN cord-010119-t1x9gknd 7589 20 and and CC cord-010119-t1x9gknd 7589 21 added add VBN cord-010119-t1x9gknd 7589 22 to to IN cord-010119-t1x9gknd 7589 23 group group NN cord-010119-t1x9gknd 7589 24 B B NNP cord-010119-t1x9gknd 7589 25 reagent reagent NN cord-010119-t1x9gknd 7589 26 red red JJ cord-010119-t1x9gknd 7589 27 blood blood NN cord-010119-t1x9gknd 7589 28 cells cell NNS cord-010119-t1x9gknd 7589 29 ( ( -LRB- cord-010119-t1x9gknd 7589 30 RBC RBC NNP cord-010119-t1x9gknd 7589 31 ) ) -RRB- cord-010119-t1x9gknd 7589 32 . . . cord-010119-t1x9gknd 7590 1 If if IN cord-010119-t1x9gknd 7590 2 any any DT cord-010119-t1x9gknd 7590 3 degree degree NN cord-010119-t1x9gknd 7590 4 of of IN cord-010119-t1x9gknd 7590 5 macroscopic macroscopic JJ cord-010119-t1x9gknd 7590 6 agglutination agglutination NN cord-010119-t1x9gknd 7590 7 after after IN cord-010119-t1x9gknd 7590 8 immediate immediate JJ cord-010119-t1x9gknd 7590 9 spin spin NN cord-010119-t1x9gknd 7590 10 was be VBD cord-010119-t1x9gknd 7590 11 observed observe VBN cord-010119-t1x9gknd 7590 12 , , , cord-010119-t1x9gknd 7590 13 the the DT cord-010119-t1x9gknd 7590 14 unit unit NN cord-010119-t1x9gknd 7590 15 was be VBD cord-010119-t1x9gknd 7590 16 considered consider VBN cord-010119-t1x9gknd 7590 17 high high JJ cord-010119-t1x9gknd 7590 18 titer titer NN cord-010119-t1x9gknd 7591 1 and and CC cord-010119-t1x9gknd 7591 2 it -PRON- PRP cord-010119-t1x9gknd 7591 3 would would MD cord-010119-t1x9gknd 7591 4 only only RB cord-010119-t1x9gknd 7591 5 have have VB cord-010119-t1x9gknd 7591 6 been be VBN cord-010119-t1x9gknd 7591 7 issued issue VBN cord-010119-t1x9gknd 7591 8 to to IN cord-010119-t1x9gknd 7591 9 group group NN cord-010119-t1x9gknd 7591 10 A A NNP cord-010119-t1x9gknd 7591 11 or or CC cord-010119-t1x9gknd 7591 12 O o NN cord-010119-t1x9gknd 7591 13 recipients recipient NNS cord-010119-t1x9gknd 7591 14 . . . cord-010119-t1x9gknd 7592 1 At at IN cord-010119-t1x9gknd 7592 2 these these DT cord-010119-t1x9gknd 7592 3 three three CD cord-010119-t1x9gknd 7592 4 centers center NNS cord-010119-t1x9gknd 7592 5 no no DT cord-010119-t1x9gknd 7592 6 temperature temperature NN cord-010119-t1x9gknd 7592 7 , , , cord-010119-t1x9gknd 7592 8 plasma plasma NN cord-010119-t1x9gknd 7592 9 volume volume NN cord-010119-t1x9gknd 7592 10 or or CC cord-010119-t1x9gknd 7592 11 time time NN cord-010119-t1x9gknd 7592 12 enhancements enhancement NNS cord-010119-t1x9gknd 7592 13 were be VBD cord-010119-t1x9gknd 7592 14 performed perform VBN cord-010119-t1x9gknd 7592 15 in in IN cord-010119-t1x9gknd 7592 16 the the DT cord-010119-t1x9gknd 7592 17 titer titer NN cord-010119-t1x9gknd 7592 18 procedure procedure NN cord-010119-t1x9gknd 7592 19 , , , cord-010119-t1x9gknd 7592 20 and and CC cord-010119-t1x9gknd 7592 21 anti anti JJ cord-010119-t1x9gknd 7592 22 - - JJ cord-010119-t1x9gknd 7592 23 human human JJ cord-010119-t1x9gknd 7592 24 globulin globulin NN cord-010119-t1x9gknd 7592 25 was be VBD cord-010119-t1x9gknd 7592 26 not not RB cord-010119-t1x9gknd 7592 27 added add VBN cord-010119-t1x9gknd 7592 28 . . . cord-010119-t1x9gknd 7593 1 At at IN cord-010119-t1x9gknd 7593 2 one one CD cord-010119-t1x9gknd 7593 3 center center NN cord-010119-t1x9gknd 7593 4 samples sample NNS cord-010119-t1x9gknd 7593 5 were be VBD cord-010119-t1x9gknd 7593 6 taken take VBN cord-010119-t1x9gknd 7593 7 from from IN cord-010119-t1x9gknd 7593 8 the the DT cord-010119-t1x9gknd 7593 9 plasma plasma NN cord-010119-t1x9gknd 7593 10 of of IN cord-010119-t1x9gknd 7593 11 group group NN cord-010119-t1x9gknd 7593 12 O O NNP cord-010119-t1x9gknd 7593 13 WB WB NNP cord-010119-t1x9gknd 7593 14 units unit NNS cord-010119-t1x9gknd 7593 15 and and CC cord-010119-t1x9gknd 7593 16 the the DT cord-010119-t1x9gknd 7593 17 same same JJ cord-010119-t1x9gknd 7593 18 procedure procedure NN cord-010119-t1x9gknd 7593 19 was be VBD cord-010119-t1x9gknd 7593 20 followed follow VBN cord-010119-t1x9gknd 7593 21 using use VBG cord-010119-t1x9gknd 7593 22 A1 A1 NNP cord-010119-t1x9gknd 7593 23 and and CC cord-010119-t1x9gknd 7593 24 B B NNP cord-010119-t1x9gknd 7593 25 reagent reagent NN cord-010119-t1x9gknd 7593 26 RBCs rbc NNS cord-010119-t1x9gknd 7593 27 ; ; : cord-010119-t1x9gknd 7593 28 if if IN cord-010119-t1x9gknd 7593 29 at at RB cord-010119-t1x9gknd 7593 30 least least RBS cord-010119-t1x9gknd 7593 31 one one CD cord-010119-t1x9gknd 7593 32 antibody antibody NN cord-010119-t1x9gknd 7593 33 demonstrated demonstrate VBD cord-010119-t1x9gknd 7593 34 macroscopic macroscopic JJ cord-010119-t1x9gknd 7593 35 agglutination agglutination NN cord-010119-t1x9gknd 7593 36 after after IN cord-010119-t1x9gknd 7593 37 immediate immediate JJ cord-010119-t1x9gknd 7593 38 spin spin NN cord-010119-t1x9gknd 7593 39 , , , cord-010119-t1x9gknd 7593 40 the the DT cord-010119-t1x9gknd 7593 41 WB WB NNP cord-010119-t1x9gknd 7593 42 unit unit NN cord-010119-t1x9gknd 7593 43 was be VBD cord-010119-t1x9gknd 7593 44 considered consider VBN cord-010119-t1x9gknd 7593 45 high high JJ cord-010119-t1x9gknd 7593 46 titer titer NN cord-010119-t1x9gknd 7594 1 and and CC cord-010119-t1x9gknd 7594 2 it -PRON- PRP cord-010119-t1x9gknd 7594 3 was be VBD cord-010119-t1x9gknd 7594 4 then then RB cord-010119-t1x9gknd 7594 5 centrifuged centrifuge VBN cord-010119-t1x9gknd 7594 6 into into IN cord-010119-t1x9gknd 7594 7 an an DT cord-010119-t1x9gknd 7594 8 RBC RBC NNP cord-010119-t1x9gknd 7594 9 unit unit NN cord-010119-t1x9gknd 7594 10 for for IN cord-010119-t1x9gknd 7594 11 transfusion transfusion NN cord-010119-t1x9gknd 7594 12 while while IN cord-010119-t1x9gknd 7594 13 the the DT cord-010119-t1x9gknd 7594 14 plasma plasma NN cord-010119-t1x9gknd 7594 15 and and CC cord-010119-t1x9gknd 7594 16 platelet platelet NN cord-010119-t1x9gknd 7594 17 components component NNS cord-010119-t1x9gknd 7594 18 were be VBD cord-010119-t1x9gknd 7594 19 discarded discard VBN cord-010119-t1x9gknd 7594 20 . . . cord-010119-t1x9gknd 7595 1 Two two CD cord-010119-t1x9gknd 7595 2 centers center NNS cord-010119-t1x9gknd 7595 3 provided provide VBD cord-010119-t1x9gknd 7595 4 plasma plasma NN cord-010119-t1x9gknd 7595 5 testing testing NN cord-010119-t1x9gknd 7595 6 data datum NNS cord-010119-t1x9gknd 7595 7 for for IN cord-010119-t1x9gknd 7595 8 a a DT cord-010119-t1x9gknd 7595 9 4-year 4-year CD cord-010119-t1x9gknd 7595 10 and and CC cord-010119-t1x9gknd 7595 11 5-year 5-year CD cord-010119-t1x9gknd 7595 12 period period NN cord-010119-t1x9gknd 7595 13 , , , cord-010119-t1x9gknd 7595 14 respectively respectively RB cord-010119-t1x9gknd 7595 15 . . . cord-010119-t1x9gknd 7596 1 One one CD cord-010119-t1x9gknd 7596 2 center center NN cord-010119-t1x9gknd 7596 3 provided provide VBD cord-010119-t1x9gknd 7596 4 plasma plasma NN cord-010119-t1x9gknd 7596 5 and and CC cord-010119-t1x9gknd 7596 6 WB WB NNP cord-010119-t1x9gknd 7596 7 testing testing NN cord-010119-t1x9gknd 7596 8 data datum NNS cord-010119-t1x9gknd 7596 9 for for IN cord-010119-t1x9gknd 7596 10 a a DT cord-010119-t1x9gknd 7596 11 1-year 1-year CD cord-010119-t1x9gknd 7596 12 period period NN cord-010119-t1x9gknd 7596 13 . . . cord-010119-t1x9gknd 7597 1 Results result NNS cord-010119-t1x9gknd 7597 2 / / SYM cord-010119-t1x9gknd 7597 3 Findings finding NNS cord-010119-t1x9gknd 7597 4 : : : cord-010119-t1x9gknd 7598 1 In in IN cord-010119-t1x9gknd 7598 2 total total NN cord-010119-t1x9gknd 7598 3 there there EX cord-010119-t1x9gknd 7598 4 were be VBD cord-010119-t1x9gknd 7598 5 7106 7106 CD cord-010119-t1x9gknd 7598 6 group group NN cord-010119-t1x9gknd 7599 1 A a DT cord-010119-t1x9gknd 7599 2 plasma plasma NN cord-010119-t1x9gknd 7599 3 units unit NNS cord-010119-t1x9gknd 7599 4 tested test VBN cord-010119-t1x9gknd 7599 5 and and CC cord-010119-t1x9gknd 7599 6 654 654 CD cord-010119-t1x9gknd 7599 7 ( ( -LRB- cord-010119-t1x9gknd 7599 8 9.2 9.2 CD cord-010119-t1x9gknd 7599 9 % % NN cord-010119-t1x9gknd 7599 10 ) ) -RRB- cord-010119-t1x9gknd 7599 11 had have VBD cord-010119-t1x9gknd 7599 12 a a DT cord-010119-t1x9gknd 7599 13 high high JJ cord-010119-t1x9gknd 7599 14 titer titer NN cord-010119-t1x9gknd 7599 15 anti anti JJ cord-010119-t1x9gknd 7599 16 - - JJ cord-010119-t1x9gknd 7599 17 B. b. NN cord-010119-t1x9gknd 7600 1 The the DT cord-010119-t1x9gknd 7600 2 range range NN cord-010119-t1x9gknd 7600 3 of of IN cord-010119-t1x9gknd 7600 4 high high JJ cord-010119-t1x9gknd 7600 5 titer titer NN cord-010119-t1x9gknd 7600 6 group group NN cord-010119-t1x9gknd 7600 7 A a DT cord-010119-t1x9gknd 7600 8 plasma plasma NN cord-010119-t1x9gknd 7600 9 units unit NNS cord-010119-t1x9gknd 7600 10 between between IN cord-010119-t1x9gknd 7600 11 these these DT cord-010119-t1x9gknd 7600 12 three three CD cord-010119-t1x9gknd 7600 13 centers center NNS cord-010119-t1x9gknd 7600 14 was be VBD cord-010119-t1x9gknd 7600 15 7.4%-12.5 7.4%-12.5 CD cord-010119-t1x9gknd 7600 16 % % NN cord-010119-t1x9gknd 7600 17 . . . cord-010119-t1x9gknd 7601 1 Of of IN cord-010119-t1x9gknd 7601 2 the the DT cord-010119-t1x9gknd 7601 3 1778 1778 CD cord-010119-t1x9gknd 7601 4 WB WB NNP cord-010119-t1x9gknd 7601 5 units unit NNS cord-010119-t1x9gknd 7601 6 tested test VBD cord-010119-t1x9gknd 7601 7 , , , cord-010119-t1x9gknd 7601 8 388 388 CD cord-010119-t1x9gknd 7601 9 ( ( -LRB- cord-010119-t1x9gknd 7601 10 21.8 21.8 CD cord-010119-t1x9gknd 7601 11 % % NN cord-010119-t1x9gknd 7601 12 ) ) -RRB- cord-010119-t1x9gknd 7601 13 units unit NNS cord-010119-t1x9gknd 7601 14 had have VBD cord-010119-t1x9gknd 7601 15 a a DT cord-010119-t1x9gknd 7601 16 high high JJ cord-010119-t1x9gknd 7601 17 titer titer NN cord-010119-t1x9gknd 7601 18 ; ; . cord-010119-t1x9gknd 7602 1 221/1778 221/1778 CD cord-010119-t1x9gknd 7602 2 ( ( -LRB- cord-010119-t1x9gknd 7602 3 12.4 12.4 CD cord-010119-t1x9gknd 7602 4 % % NN cord-010119-t1x9gknd 7602 5 ) ) -RRB- cord-010119-t1x9gknd 7602 6 of of IN cord-010119-t1x9gknd 7602 7 the the DT cord-010119-t1x9gknd 7602 8 units unit NNS cord-010119-t1x9gknd 7602 9 had have VBD cord-010119-t1x9gknd 7602 10 a a DT cord-010119-t1x9gknd 7602 11 high high JJ cord-010119-t1x9gknd 7602 12 titer titer NN cord-010119-t1x9gknd 7602 13 anti anti NN cord-010119-t1x9gknd 7602 14 - - NNP cord-010119-t1x9gknd 7602 15 A a NN cord-010119-t1x9gknd 7602 16 , , , cord-010119-t1x9gknd 7602 17 61/1778 61/1778 CD cord-010119-t1x9gknd 7602 18 ( ( -LRB- cord-010119-t1x9gknd 7602 19 3.4 3.4 CD cord-010119-t1x9gknd 7602 20 % % NN cord-010119-t1x9gknd 7602 21 ) ) -RRB- cord-010119-t1x9gknd 7602 22 had have VBD cord-010119-t1x9gknd 7602 23 a a DT cord-010119-t1x9gknd 7602 24 high high JJ cord-010119-t1x9gknd 7602 25 titer titer NN cord-010119-t1x9gknd 7602 26 anti anti NN cord-010119-t1x9gknd 7602 27 - - NN cord-010119-t1x9gknd 7602 28 B B NNP cord-010119-t1x9gknd 7602 29 , , , cord-010119-t1x9gknd 7602 30 and and CC cord-010119-t1x9gknd 7602 31 106/1778 106/1778 CD cord-010119-t1x9gknd 7602 32 ( ( -LRB- cord-010119-t1x9gknd 7602 33 6 6 CD cord-010119-t1x9gknd 7602 34 % % NN cord-010119-t1x9gknd 7602 35 ) ) -RRB- cord-010119-t1x9gknd 7602 36 had have VBD cord-010119-t1x9gknd 7602 37 high high JJ cord-010119-t1x9gknd 7602 38 titers titer NNS cord-010119-t1x9gknd 7602 39 of of IN cord-010119-t1x9gknd 7602 40 both both CC cord-010119-t1x9gknd 7602 41 anti anti JJ cord-010119-t1x9gknd 7602 42 - - JJ cord-010119-t1x9gknd 7602 43 A a NN cord-010119-t1x9gknd 7603 1 and and CC cord-010119-t1x9gknd 7603 2 anti anti JJ cord-010119-t1x9gknd 7603 3 - - NNP cord-010119-t1x9gknd 7603 4 B. B. NNP cord-010119-t1x9gknd 7603 5 Background Background NNP cord-010119-t1x9gknd 7603 6 / / SYM cord-010119-t1x9gknd 7603 7 Case Case NNP cord-010119-t1x9gknd 7603 8 Studies Studies NNPS cord-010119-t1x9gknd 7603 9 : : : cord-010119-t1x9gknd 7603 10 Dithiothreiol Dithiothreiol NNP cord-010119-t1x9gknd 7603 11 ( ( -LRB- cord-010119-t1x9gknd 7603 12 DTT DTT NNP cord-010119-t1x9gknd 7603 13 ) ) -RRB- cord-010119-t1x9gknd 7603 14 is be VBZ cord-010119-t1x9gknd 7603 15 a a DT cord-010119-t1x9gknd 7603 16 sulfhydryl sulfhydryl NN cord-010119-t1x9gknd 7603 17 reagent reagent NN cord-010119-t1x9gknd 7603 18 that that WDT cord-010119-t1x9gknd 7603 19 denatures denature VBZ cord-010119-t1x9gknd 7603 20 selective selective JJ cord-010119-t1x9gknd 7603 21 blood blood NN cord-010119-t1x9gknd 7603 22 group group NN cord-010119-t1x9gknd 7603 23 antigens antigen NNS cord-010119-t1x9gknd 7603 24 . . . cord-010119-t1x9gknd 7604 1 Reagent reagent JJ cord-010119-t1x9gknd 7604 2 red red JJ cord-010119-t1x9gknd 7604 3 blood blood NN cord-010119-t1x9gknd 7604 4 cells cell NNS cord-010119-t1x9gknd 7604 5 ( ( -LRB- cord-010119-t1x9gknd 7604 6 RBCs rbc NNS cord-010119-t1x9gknd 7604 7 ) ) -RRB- cord-010119-t1x9gknd 7604 8 treated treat VBN cord-010119-t1x9gknd 7604 9 with with IN cord-010119-t1x9gknd 7604 10 0.2 0.2 CD cord-010119-t1x9gknd 7604 11 M M NNP cord-010119-t1x9gknd 7604 12 DTT DTT NNP cord-010119-t1x9gknd 7604 13 is be VBZ cord-010119-t1x9gknd 7604 14 used use VBN cord-010119-t1x9gknd 7604 15 as as IN cord-010119-t1x9gknd 7604 16 a a DT cord-010119-t1x9gknd 7604 17 tool tool NN cord-010119-t1x9gknd 7604 18 in in IN cord-010119-t1x9gknd 7604 19 identifying identify VBG cord-010119-t1x9gknd 7604 20 antibodies antibody NNS cord-010119-t1x9gknd 7604 21 to to IN cord-010119-t1x9gknd 7604 22 high high JJ cord-010119-t1x9gknd 7604 23 frequency frequency NN cord-010119-t1x9gknd 7604 24 antigens antigen NNS cord-010119-t1x9gknd 7604 25 . . . cord-010119-t1x9gknd 7605 1 Recently recently RB cord-010119-t1x9gknd 7605 2 , , , cord-010119-t1x9gknd 7605 3 DTT DTT NNP cord-010119-t1x9gknd 7605 4 has have VBZ cord-010119-t1x9gknd 7605 5 become become VBN cord-010119-t1x9gknd 7605 6 widely widely RB cord-010119-t1x9gknd 7605 7 used use VBN cord-010119-t1x9gknd 7605 8 in in IN cord-010119-t1x9gknd 7605 9 destroying destroy VBG cord-010119-t1x9gknd 7605 10 CD38 CD38 NNP cord-010119-t1x9gknd 7605 11 on on IN cord-010119-t1x9gknd 7605 12 reagent reagent NN cord-010119-t1x9gknd 7605 13 RBCs rbc NNS cord-010119-t1x9gknd 7605 14 and and CC cord-010119-t1x9gknd 7605 15 render render VB cord-010119-t1x9gknd 7605 16 them -PRON- PRP cord-010119-t1x9gknd 7605 17 free free JJ cord-010119-t1x9gknd 7605 18 from from IN cord-010119-t1x9gknd 7605 19 plasma plasma NN cord-010119-t1x9gknd 7605 20 anti anti JJ cord-010119-t1x9gknd 7605 21 - - JJ cord-010119-t1x9gknd 7605 22 CD38 cd38 JJ cord-010119-t1x9gknd 7605 23 drug drug NN cord-010119-t1x9gknd 7605 24 interference interference NN cord-010119-t1x9gknd 7605 25 . . . cord-010119-t1x9gknd 7606 1 Procedures procedure NNS cord-010119-t1x9gknd 7606 2 for for IN cord-010119-t1x9gknd 7606 3 the the DT cord-010119-t1x9gknd 7606 4 preparation preparation NN cord-010119-t1x9gknd 7606 5 of of IN cord-010119-t1x9gknd 7606 6 0.2 0.2 CD cord-010119-t1x9gknd 7606 7 M M NNP cord-010119-t1x9gknd 7606 8 DTT DTT NNP cord-010119-t1x9gknd 7606 9 has have VBZ cord-010119-t1x9gknd 7606 10 been be VBN cord-010119-t1x9gknd 7606 11 published publish VBN cord-010119-t1x9gknd 7606 12 advocating advocate VBG cord-010119-t1x9gknd 7606 13 the the DT cord-010119-t1x9gknd 7606 14 use use NN cord-010119-t1x9gknd 7606 15 of of IN cord-010119-t1x9gknd 7606 16 buffered buffered JJ cord-010119-t1x9gknd 7606 17 saline saline NN cord-010119-t1x9gknd 7606 18 at at IN cord-010119-t1x9gknd 7606 19 different different JJ cord-010119-t1x9gknd 7606 20 pH pH NNP cord-010119-t1x9gknd 7606 21 levels level NNS cord-010119-t1x9gknd 7606 22 . . . cord-010119-t1x9gknd 7607 1 In in IN cord-010119-t1x9gknd 7607 2 this this DT cord-010119-t1x9gknd 7607 3 study study NN cord-010119-t1x9gknd 7607 4 , , , cord-010119-t1x9gknd 7607 5 an an DT cord-010119-t1x9gknd 7607 6 effect effect NN cord-010119-t1x9gknd 7607 7 of of IN cord-010119-t1x9gknd 7607 8 pH ph NN cord-010119-t1x9gknd 7607 9 on on IN cord-010119-t1x9gknd 7607 10 0.2 0.2 CD cord-010119-t1x9gknd 7607 11 M M NNP cord-010119-t1x9gknd 7607 12 DTT DTT NNP cord-010119-t1x9gknd 7607 13 treatment treatment NN cord-010119-t1x9gknd 7607 14 time time NN cord-010119-t1x9gknd 7607 15 is be VBZ cord-010119-t1x9gknd 7607 16 investigated investigate VBN cord-010119-t1x9gknd 7607 17 . . . cord-010119-t1x9gknd 7608 1 Study Study NNP cord-010119-t1x9gknd 7608 2 Design Design NNP cord-010119-t1x9gknd 7608 3 / / SYM cord-010119-t1x9gknd 7608 4 Methods method NNS cord-010119-t1x9gknd 7608 5 : : : cord-010119-t1x9gknd 7608 6 Non non JJ cord-010119-t1x9gknd 7608 7 - - JJ cord-010119-t1x9gknd 7608 8 buffered buffered JJ cord-010119-t1x9gknd 7608 9 saline saline NN cord-010119-t1x9gknd 7608 10 ( ( -LRB- cord-010119-t1x9gknd 7608 11 NBS NBS NNP cord-010119-t1x9gknd 7608 12 , , , cord-010119-t1x9gknd 7608 13 Thermo Thermo NNP cord-010119-t1x9gknd 7608 14 Fischer Fischer NNP cord-010119-t1x9gknd 7608 15 Scientific Scientific NNP cord-010119-t1x9gknd 7608 16 Inc Inc NNP cord-010119-t1x9gknd 7608 17 , , , cord-010119-t1x9gknd 7608 18 Middletown Middletown NNP cord-010119-t1x9gknd 7608 19 , , , cord-010119-t1x9gknd 7608 20 VA VA NNP cord-010119-t1x9gknd 7608 21 ) ) -RRB- cord-010119-t1x9gknd 7608 22 , , , cord-010119-t1x9gknd 7608 23 used use VBN cord-010119-t1x9gknd 7608 24 in in IN cord-010119-t1x9gknd 7608 25 the the DT cord-010119-t1x9gknd 7608 26 preparation preparation NN cord-010119-t1x9gknd 7608 27 of of IN cord-010119-t1x9gknd 7608 28 0.2 0.2 CD cord-010119-t1x9gknd 7608 29 M M NNP cord-010119-t1x9gknd 7608 30 DTT DTT NNP cord-010119-t1x9gknd 7608 31 , , , cord-010119-t1x9gknd 7608 32 was be VBD cord-010119-t1x9gknd 7608 33 adjusted adjust VBN cord-010119-t1x9gknd 7608 34 to to IN cord-010119-t1x9gknd 7608 35 pH7.16 ph7.16 CD cord-010119-t1x9gknd 7608 36 , , , cord-010119-t1x9gknd 7608 37 pH pH NNP cord-010119-t1x9gknd 7608 38 7.56 7.56 CD cord-010119-t1x9gknd 7608 39 , , , cord-010119-t1x9gknd 7608 40 pH ph NN cord-010119-t1x9gknd 7608 41 7.96 7.96 CD cord-010119-t1x9gknd 7608 42 using use VBG cord-010119-t1x9gknd 7608 43 sodium sodium NN cord-010119-t1x9gknd 7608 44 phosphate phosphate NN cord-010119-t1x9gknd 7608 45 dibasis dibasis NN cord-010119-t1x9gknd 7608 46 ( ( -LRB- cord-010119-t1x9gknd 7608 47 Sigma Sigma NNP cord-010119-t1x9gknd 7608 48 Aldrich Aldrich NNP cord-010119-t1x9gknd 7608 49 , , , cord-010119-t1x9gknd 7608 50 Saint Saint NNP cord-010119-t1x9gknd 7608 51 Louis Louis NNP cord-010119-t1x9gknd 7608 52 , , , cord-010119-t1x9gknd 7608 53 MO MO NNP cord-010119-t1x9gknd 7608 54 ) ) -RRB- cord-010119-t1x9gknd 7608 55 . . . cord-010119-t1x9gknd 7609 1 Reagent reagent NN cord-010119-t1x9gknd 7609 2 RBCs rbc NNS cord-010119-t1x9gknd 7609 3 ( ( -LRB- cord-010119-t1x9gknd 7609 4 Immucor Immucor NNP cord-010119-t1x9gknd 7609 5 , , , cord-010119-t1x9gknd 7609 6 Norcross Norcross NNP cord-010119-t1x9gknd 7609 7 , , , cord-010119-t1x9gknd 7609 8 GA)(n53 GA)(n53 NNP cord-010119-t1x9gknd 7609 9 ) ) -RRB- cord-010119-t1x9gknd 7609 10 were be VBD cord-010119-t1x9gknd 7609 11 treated treat VBN cord-010119-t1x9gknd 7609 12 with with IN cord-010119-t1x9gknd 7609 13 the the DT cord-010119-t1x9gknd 7609 14 0.2 0.2 CD cord-010119-t1x9gknd 7609 15 M M NNP cord-010119-t1x9gknd 7609 16 DTT DTT NNP cord-010119-t1x9gknd 7609 17 solutions solution NNS cord-010119-t1x9gknd 7609 18 in in IN cord-010119-t1x9gknd 7609 19 parallel parallel NN cord-010119-t1x9gknd 7609 20 by by IN cord-010119-t1x9gknd 7609 21 mixing mix VBG cord-010119-t1x9gknd 7609 22 1:4 1:4 CD cord-010119-t1x9gknd 7609 23 ratio ratio NN cord-010119-t1x9gknd 7609 24 of of IN cord-010119-t1x9gknd 7609 25 packed packed JJ cord-010119-t1x9gknd 7609 26 RBCs rbc NNS cord-010119-t1x9gknd 7609 27 to to IN cord-010119-t1x9gknd 7609 28 0.2 0.2 CD cord-010119-t1x9gknd 7609 29 M M NNP cord-010119-t1x9gknd 7609 30 DTT DTT NNP cord-010119-t1x9gknd 7609 31 solution solution NN cord-010119-t1x9gknd 7609 32 followed follow VBN cord-010119-t1x9gknd 7609 33 by by IN cord-010119-t1x9gknd 7609 34 incubation incubation NN cord-010119-t1x9gknd 7609 35 at at IN cord-010119-t1x9gknd 7609 36 378C. 378c. NN cord-010119-t1x9gknd 7609 37 For for IN cord-010119-t1x9gknd 7609 38 up up IN cord-010119-t1x9gknd 7609 39 to to TO cord-010119-t1x9gknd 7609 40 45 45 CD cord-010119-t1x9gknd 7609 41 minutes minute NNS cord-010119-t1x9gknd 7609 42 during during IN cord-010119-t1x9gknd 7609 43 treatment treatment NN cord-010119-t1x9gknd 7609 44 , , , cord-010119-t1x9gknd 7609 45 the the DT cord-010119-t1x9gknd 7609 46 expression expression NN cord-010119-t1x9gknd 7609 47 of of IN cord-010119-t1x9gknd 7609 48 k k NN cord-010119-t1x9gknd 7609 49 antigens antigen NNS cord-010119-t1x9gknd 7609 50 was be VBD cord-010119-t1x9gknd 7609 51 measured measure VBN cord-010119-t1x9gknd 7609 52 every every DT cord-010119-t1x9gknd 7609 53 5 5 CD cord-010119-t1x9gknd 7609 54 minutes minute NNS cord-010119-t1x9gknd 7609 55 by by IN cord-010119-t1x9gknd 7609 56 tube tube NN cord-010119-t1x9gknd 7609 57 method method NN cord-010119-t1x9gknd 7609 58 using use VBG cord-010119-t1x9gknd 7609 59 2 2 CD cord-010119-t1x9gknd 7609 60 different different JJ cord-010119-t1x9gknd 7609 61 sources source NNS cord-010119-t1x9gknd 7609 62 of of IN cord-010119-t1x9gknd 7609 63 anti anti JJ cord-010119-t1x9gknd 7609 64 - - JJ cord-010119-t1x9gknd 7609 65 k k NN cord-010119-t1x9gknd 7609 66 . . . cord-010119-t1x9gknd 7610 1 To to TO cord-010119-t1x9gknd 7610 2 assure assure VB cord-010119-t1x9gknd 7610 3 uniformity uniformity NN cord-010119-t1x9gknd 7610 4 , , , cord-010119-t1x9gknd 7610 5 all all DT cord-010119-t1x9gknd 7610 6 reactions reaction NNS cord-010119-t1x9gknd 7610 7 were be VBD cord-010119-t1x9gknd 7610 8 graded grade VBN cord-010119-t1x9gknd 7610 9 by by IN cord-010119-t1x9gknd 7610 10 the the DT cord-010119-t1x9gknd 7610 11 same same JJ cord-010119-t1x9gknd 7610 12 investigator investigator NN cord-010119-t1x9gknd 7610 13 . . . cord-010119-t1x9gknd 7611 1 Each each DT cord-010119-t1x9gknd 7611 2 reaction reaction NN cord-010119-t1x9gknd 7611 3 grade grade NN cord-010119-t1x9gknd 7611 4 ( ( -LRB- cord-010119-t1x9gknd 7611 5 in in IN cord-010119-t1x9gknd 7611 6 each each DT cord-010119-t1x9gknd 7611 7 RBC RBC NNP cord-010119-t1x9gknd 7611 8 and and CC cord-010119-t1x9gknd 7611 9 each each DT cord-010119-t1x9gknd 7611 10 antiserum antiserum NN cord-010119-t1x9gknd 7611 11 ) ) -RRB- cord-010119-t1x9gknd 7611 12 is be VBZ cord-010119-t1x9gknd 7611 13 converted convert VBN cord-010119-t1x9gknd 7611 14 into into IN cord-010119-t1x9gknd 7611 15 a a DT cord-010119-t1x9gknd 7611 16 semiquantitive semiquantitive JJ cord-010119-t1x9gknd 7611 17 score score NN cord-010119-t1x9gknd 7611 18 and and CC cord-010119-t1x9gknd 7611 19 an an DT cord-010119-t1x9gknd 7611 20 average average JJ cord-010119-t1x9gknd 7611 21 score score NN cord-010119-t1x9gknd 7611 22 was be VBD cord-010119-t1x9gknd 7611 23 calculated calculate VBN cord-010119-t1x9gknd 7611 24 every every DT cord-010119-t1x9gknd 7611 25 5 5 CD cord-010119-t1x9gknd 7611 26 minutes minute NNS cord-010119-t1x9gknd 7611 27 for for IN cord-010119-t1x9gknd 7611 28 each each DT cord-010119-t1x9gknd 7611 29 pH pH NNP cord-010119-t1x9gknd 7611 30 level level NN cord-010119-t1x9gknd 7611 31 . . . cord-010119-t1x9gknd 7612 1 The the DT cord-010119-t1x9gknd 7612 2 reduction reduction NN cord-010119-t1x9gknd 7612 3 in in IN cord-010119-t1x9gknd 7612 4 average average JJ cord-010119-t1x9gknd 7612 5 scores score NNS cord-010119-t1x9gknd 7612 6 between between IN cord-010119-t1x9gknd 7612 7 different different JJ cord-010119-t1x9gknd 7612 8 pHs pHs NNPS cord-010119-t1x9gknd 7612 9 were be VBD cord-010119-t1x9gknd 7612 10 also also RB cord-010119-t1x9gknd 7612 11 calculated calculate VBN cord-010119-t1x9gknd 7612 12 at at IN cord-010119-t1x9gknd 7612 13 every every DT cord-010119-t1x9gknd 7612 14 5 5 CD cord-010119-t1x9gknd 7612 15 minutes minute NNS cord-010119-t1x9gknd 7612 16 to to TO cord-010119-t1x9gknd 7612 17 measure measure VB cord-010119-t1x9gknd 7612 18 the the DT cord-010119-t1x9gknd 7612 19 impact impact NN cord-010119-t1x9gknd 7612 20 of of IN cord-010119-t1x9gknd 7612 21 0.2 0.2 CD cord-010119-t1x9gknd 7612 22 M M NNP cord-010119-t1x9gknd 7612 23 DTT DTT NNP cord-010119-t1x9gknd 7612 24 reagent reagent NN cord-010119-t1x9gknd 7612 25 pH ph NN cord-010119-t1x9gknd 7612 26 on on IN cord-010119-t1x9gknd 7612 27 the the DT cord-010119-t1x9gknd 7612 28 rate rate NN cord-010119-t1x9gknd 7612 29 of of IN cord-010119-t1x9gknd 7612 30 k k NNP cord-010119-t1x9gknd 7612 31 antigen antigen NNP cord-010119-t1x9gknd 7612 32 destruction destruction NN cord-010119-t1x9gknd 7612 33 . . . cord-010119-t1x9gknd 7613 1 Results result NNS cord-010119-t1x9gknd 7613 2 / / SYM cord-010119-t1x9gknd 7613 3 Findings finding NNS cord-010119-t1x9gknd 7613 4 : : : cord-010119-t1x9gknd 7613 5 The the DT cord-010119-t1x9gknd 7613 6 expression expression NN cord-010119-t1x9gknd 7613 7 of of IN cord-010119-t1x9gknd 7613 8 k k NNP cord-010119-t1x9gknd 7613 9 antigen antigen NNP cord-010119-t1x9gknd 7613 10 , , , cord-010119-t1x9gknd 7613 11 measured measure VBN cord-010119-t1x9gknd 7613 12 by by IN cord-010119-t1x9gknd 7613 13 agglutination agglutination NN cord-010119-t1x9gknd 7613 14 grades grade NNS cord-010119-t1x9gknd 7613 15 with with IN cord-010119-t1x9gknd 7613 16 two two CD cord-010119-t1x9gknd 7613 17 different different JJ cord-010119-t1x9gknd 7613 18 k k NNP cord-010119-t1x9gknd 7613 19 antisera antisera NNP cord-010119-t1x9gknd 7613 20 , , , cord-010119-t1x9gknd 7613 21 is be VBZ cord-010119-t1x9gknd 7613 22 significantly significantly RB cord-010119-t1x9gknd 7613 23 weakened weaken VBN cord-010119-t1x9gknd 7613 24 ( ( -LRB- cord-010119-t1x9gknd 7613 25 by by IN cord-010119-t1x9gknd 7613 26 ! ! . cord-010119-t1x9gknd 7613 27 11 11 CD cord-010119-t1x9gknd 7613 28 ) ) -RRB- cord-010119-t1x9gknd 7613 29 after after IN cord-010119-t1x9gknd 7613 30 15 15 CD cord-010119-t1x9gknd 7613 31 minutes minute NNS cord-010119-t1x9gknd 7613 32 of of IN cord-010119-t1x9gknd 7613 33 DTT DTT NNP cord-010119-t1x9gknd 7613 34 treatment treatment NN cord-010119-t1x9gknd 7613 35 at at IN cord-010119-t1x9gknd 7613 36 pH pH NNP cord-010119-t1x9gknd 7613 37 7.96 7.96 CD cord-010119-t1x9gknd 7613 38 ; ; : cord-010119-t1x9gknd 7613 39 15 15 CD cord-010119-t1x9gknd 7613 40 minutes minute NNS cord-010119-t1x9gknd 7613 41 at at IN cord-010119-t1x9gknd 7613 42 pH7.56 ph7.56 CD cord-010119-t1x9gknd 7613 43 and and CC cord-010119-t1x9gknd 7613 44 20 20 CD cord-010119-t1x9gknd 7613 45 minutes minute NNS cord-010119-t1x9gknd 7613 46 at at IN cord-010119-t1x9gknd 7613 47 pH7.16 ph7.16 CD cord-010119-t1x9gknd 7613 48 . . . cord-010119-t1x9gknd 7614 1 Complete complete JJ cord-010119-t1x9gknd 7614 2 loss loss NN cord-010119-t1x9gknd 7614 3 of of IN cord-010119-t1x9gknd 7614 4 k k NN cord-010119-t1x9gknd 7614 5 expression expression NN cord-010119-t1x9gknd 7614 6 was be VBD cord-010119-t1x9gknd 7614 7 seen see VBN cord-010119-t1x9gknd 7614 8 after after IN cord-010119-t1x9gknd 7614 9 25 25 CD cord-010119-t1x9gknd 7614 10 minutes minute NNS cord-010119-t1x9gknd 7614 11 of of IN cord-010119-t1x9gknd 7614 12 DTT DTT NNP cord-010119-t1x9gknd 7614 13 treatment treatment NN cord-010119-t1x9gknd 7614 14 at at IN cord-010119-t1x9gknd 7614 15 pH7.96 ph7.96 CD cord-010119-t1x9gknd 7614 16 ; ; : cord-010119-t1x9gknd 7614 17 35 35 CD cord-010119-t1x9gknd 7614 18 minutes minute NNS cord-010119-t1x9gknd 7614 19 at at IN cord-010119-t1x9gknd 7614 20 pH7.56 ph7.56 CD cord-010119-t1x9gknd 7614 21 and and CC cord-010119-t1x9gknd 7614 22 35 35 CD cord-010119-t1x9gknd 7614 23 minutes minute NNS cord-010119-t1x9gknd 7614 24 at at IN cord-010119-t1x9gknd 7614 25 pH pH NNP cord-010119-t1x9gknd 7614 26 7.16 7.16 CD cord-010119-t1x9gknd 7614 27 . . . cord-010119-t1x9gknd 7615 1 The the DT cord-010119-t1x9gknd 7615 2 reactivity reactivity NN cord-010119-t1x9gknd 7615 3 patterns pattern NNS cord-010119-t1x9gknd 7615 4 of of IN cord-010119-t1x9gknd 7615 5 k k NNP cord-010119-t1x9gknd 7615 6 antigen antigen NNP cord-010119-t1x9gknd 7615 7 tested test VBN cord-010119-t1x9gknd 7615 8 with with IN cord-010119-t1x9gknd 7615 9 2 2 CD cord-010119-t1x9gknd 7615 10 sources source NNS cord-010119-t1x9gknd 7615 11 of of IN cord-010119-t1x9gknd 7615 12 anti anti JJ cord-010119-t1x9gknd 7615 13 - - JJ cord-010119-t1x9gknd 7615 14 k k JJ cord-010119-t1x9gknd 7616 1 correlate correlate VB cord-010119-t1x9gknd 7616 2 with with IN cord-010119-t1x9gknd 7616 3 each each DT cord-010119-t1x9gknd 7616 4 other other JJ cord-010119-t1x9gknd 7616 5 . . . cord-010119-t1x9gknd 7617 1 The the DT cord-010119-t1x9gknd 7617 2 reductions reduction NNS cord-010119-t1x9gknd 7617 3 in in IN cord-010119-t1x9gknd 7617 4 average average JJ cord-010119-t1x9gknd 7617 5 scores score NNS cord-010119-t1x9gknd 7617 6 were be VBD cord-010119-t1x9gknd 7617 7 seen see VBN cord-010119-t1x9gknd 7617 8 between between IN cord-010119-t1x9gknd 7617 9 15 15 CD cord-010119-t1x9gknd 7617 10 to to TO cord-010119-t1x9gknd 7617 11 30 30 CD cord-010119-t1x9gknd 7617 12 minutes minute NNS cord-010119-t1x9gknd 7617 13 range range NN cord-010119-t1x9gknd 7617 14 of of IN cord-010119-t1x9gknd 7617 15 DTT DTT NNP cord-010119-t1x9gknd 7617 16 treatment treatment NN cord-010119-t1x9gknd 7617 17 time time NN cord-010119-t1x9gknd 7617 18 when when WRB cord-010119-t1x9gknd 7617 19 pH pH NNP cord-010119-t1x9gknd 7617 20 7.16 7.16 CD cord-010119-t1x9gknd 7617 21 was be VBD cord-010119-t1x9gknd 7617 22 raised raise VBN cord-010119-t1x9gknd 7617 23 to to IN cord-010119-t1x9gknd 7617 24 pH7.56 pH7.56 NNP cord-010119-t1x9gknd 7617 25 ; ; : cord-010119-t1x9gknd 7617 26 15 15 CD cord-010119-t1x9gknd 7617 27 to to TO cord-010119-t1x9gknd 7617 28 30minutes 30minutes CD cord-010119-t1x9gknd 7617 29 range range NN cord-010119-t1x9gknd 7617 30 when when WRB cord-010119-t1x9gknd 7617 31 pH7.56 pH7.56 NNP cord-010119-t1x9gknd 7617 32 was be VBD cord-010119-t1x9gknd 7617 33 raised raise VBN cord-010119-t1x9gknd 7617 34 to to IN cord-010119-t1x9gknd 7617 35 pH7.96 ph7.96 CD cord-010119-t1x9gknd 7617 36 ; ; : cord-010119-t1x9gknd 7617 37 and and CC cord-010119-t1x9gknd 7617 38 15 15 CD cord-010119-t1x9gknd 7617 39 to to TO cord-010119-t1x9gknd 7617 40 30 30 CD cord-010119-t1x9gknd 7617 41 minutes minute NNS cord-010119-t1x9gknd 7617 42 range range NN cord-010119-t1x9gknd 7617 43 when when WRB cord-010119-t1x9gknd 7617 44 pH7.16 ph7.16 CD cord-010119-t1x9gknd 7617 45 was be VBD cord-010119-t1x9gknd 7617 46 raised raise VBN cord-010119-t1x9gknd 7617 47 to to IN cord-010119-t1x9gknd 7617 48 pH7.96 ph7.96 CD cord-010119-t1x9gknd 7617 49 . . . cord-010119-t1x9gknd 7618 1 Conclusion conclusion NN cord-010119-t1x9gknd 7618 2 : : : cord-010119-t1x9gknd 7619 1 The the DT cord-010119-t1x9gknd 7619 2 use use NN cord-010119-t1x9gknd 7619 3 of of IN cord-010119-t1x9gknd 7619 4 higher high JJR cord-010119-t1x9gknd 7619 5 pH ph NN cord-010119-t1x9gknd 7619 6 buffered buffer VBN cord-010119-t1x9gknd 7619 7 saline saline NN cord-010119-t1x9gknd 7619 8 may may MD cord-010119-t1x9gknd 7619 9 shorten shorten VB cord-010119-t1x9gknd 7619 10 the the DT cord-010119-t1x9gknd 7619 11 treatment treatment NN cord-010119-t1x9gknd 7619 12 time time NN cord-010119-t1x9gknd 7619 13 it -PRON- PRP cord-010119-t1x9gknd 7619 14 takes take VBZ cord-010119-t1x9gknd 7619 15 to to TO cord-010119-t1x9gknd 7619 16 weaken weaken VB cord-010119-t1x9gknd 7619 17 or or CC cord-010119-t1x9gknd 7619 18 destroy destroy VB cord-010119-t1x9gknd 7619 19 k k NNP cord-010119-t1x9gknd 7619 20 antigen antigen NN cord-010119-t1x9gknd 7619 21 . . . cord-010119-t1x9gknd 7620 1 Based base VBN cord-010119-t1x9gknd 7620 2 on on IN cord-010119-t1x9gknd 7620 3 the the DT cord-010119-t1x9gknd 7620 4 comparison comparison NN cord-010119-t1x9gknd 7620 5 of of IN cord-010119-t1x9gknd 7620 6 reaction reaction NN cord-010119-t1x9gknd 7620 7 scores score NNS cord-010119-t1x9gknd 7620 8 between between IN cord-010119-t1x9gknd 7620 9 different different JJ cord-010119-t1x9gknd 7620 10 pH pH NNP cord-010119-t1x9gknd 7620 11 levels level NNS cord-010119-t1x9gknd 7620 12 , , , cord-010119-t1x9gknd 7620 13 the the DT cord-010119-t1x9gknd 7620 14 pH pH NNP cord-010119-t1x9gknd 7620 15 levels level NNS cord-010119-t1x9gknd 7620 16 did do VBD cord-010119-t1x9gknd 7620 17 not not RB cord-010119-t1x9gknd 7620 18 have have VB cord-010119-t1x9gknd 7620 19 an an DT cord-010119-t1x9gknd 7620 20 impact impact NN cord-010119-t1x9gknd 7620 21 on on IN cord-010119-t1x9gknd 7620 22 DTT DTT NNP cord-010119-t1x9gknd 7620 23 treatment treatment NN cord-010119-t1x9gknd 7620 24 up up IN cord-010119-t1x9gknd 7620 25 to to TO cord-010119-t1x9gknd 7620 26 15 15 CD cord-010119-t1x9gknd 7620 27 minutes minute NNS cord-010119-t1x9gknd 7620 28 and/or and/or CC cord-010119-t1x9gknd 7620 29 beyond beyond IN cord-010119-t1x9gknd 7620 30 35 35 CD cord-010119-t1x9gknd 7620 31 minutes minute NNS cord-010119-t1x9gknd 7620 32 of of IN cord-010119-t1x9gknd 7620 33 incubation incubation NN cord-010119-t1x9gknd 7620 34 . . . cord-010119-t1x9gknd 7621 1 The the DT cord-010119-t1x9gknd 7621 2 pH ph NN cord-010119-t1x9gknd 7621 3 of of IN cord-010119-t1x9gknd 7621 4 the the DT cord-010119-t1x9gknd 7621 5 0.2 0.2 CD cord-010119-t1x9gknd 7621 6 M M NNP cord-010119-t1x9gknd 7621 7 DTT DTT NNP cord-010119-t1x9gknd 7621 8 reagent reagent NN cord-010119-t1x9gknd 7621 9 relative relative NN cord-010119-t1x9gknd 7621 10 to to IN cord-010119-t1x9gknd 7621 11 the the DT cord-010119-t1x9gknd 7621 12 treatment treatment NN cord-010119-t1x9gknd 7621 13 time time NN cord-010119-t1x9gknd 7621 14 is be VBZ cord-010119-t1x9gknd 7621 15 a a DT cord-010119-t1x9gknd 7621 16 factor factor NN cord-010119-t1x9gknd 7621 17 to to TO cord-010119-t1x9gknd 7621 18 consider consider VB cord-010119-t1x9gknd 7621 19 during during IN cord-010119-t1x9gknd 7621 20 the the DT cord-010119-t1x9gknd 7621 21 validation validation NN cord-010119-t1x9gknd 7621 22 of of IN cord-010119-t1x9gknd 7621 23 DTT dtt NN cord-010119-t1x9gknd 7621 24 - - HYPH cord-010119-t1x9gknd 7621 25 treatment treatment NN cord-010119-t1x9gknd 7621 26 process process NN cord-010119-t1x9gknd 7621 27 and and CC cord-010119-t1x9gknd 7621 28 qualification qualification NN cord-010119-t1x9gknd 7621 29 of of IN cord-010119-t1x9gknd 7621 30 0.2 0.2 CD cord-010119-t1x9gknd 7621 31 M M NNP cord-010119-t1x9gknd 7621 32 DTT DTT NNP cord-010119-t1x9gknd 7621 33 reagent reagent NN cord-010119-t1x9gknd 7621 34 in in IN cord-010119-t1x9gknd 7621 35 a a DT cord-010119-t1x9gknd 7621 36 laboratory laboratory NN cord-010119-t1x9gknd 7621 37 . . . cord-010119-t1x9gknd 7622 1 Background Background NNP cord-010119-t1x9gknd 7622 2 / / SYM cord-010119-t1x9gknd 7622 3 Case Case NNP cord-010119-t1x9gknd 7622 4 Studies Studies NNPS cord-010119-t1x9gknd 7622 5 : : : cord-010119-t1x9gknd 7622 6 Data datum NNS cord-010119-t1x9gknd 7622 7 on on IN cord-010119-t1x9gknd 7622 8 the the DT cord-010119-t1x9gknd 7622 9 characteristics characteristic NNS cord-010119-t1x9gknd 7622 10 and and CC cord-010119-t1x9gknd 7622 11 frequencies frequency NNS cord-010119-t1x9gknd 7622 12 of of IN cord-010119-t1x9gknd 7622 13 clinically clinically RB cord-010119-t1x9gknd 7622 14 significant significant JJ cord-010119-t1x9gknd 7622 15 red red JJ cord-010119-t1x9gknd 7622 16 cell cell NN cord-010119-t1x9gknd 7622 17 antibodies antibody NNS cord-010119-t1x9gknd 7622 18 within within IN cord-010119-t1x9gknd 7622 19 the the DT cord-010119-t1x9gknd 7622 20 prenatal prenatal JJ cord-010119-t1x9gknd 7622 21 population population NN cord-010119-t1x9gknd 7622 22 have have VBP cord-010119-t1x9gknd 7622 23 not not RB cord-010119-t1x9gknd 7622 24 been be VBN cord-010119-t1x9gknd 7622 25 well well RB cord-010119-t1x9gknd 7622 26 established establish VBN cord-010119-t1x9gknd 7622 27 in in IN cord-010119-t1x9gknd 7622 28 the the DT cord-010119-t1x9gknd 7622 29 United United NNP cord-010119-t1x9gknd 7622 30 States States NNP cord-010119-t1x9gknd 7622 31 . . . cord-010119-t1x9gknd 7623 1 The the DT cord-010119-t1x9gknd 7623 2 aim aim NN cord-010119-t1x9gknd 7623 3 of of IN cord-010119-t1x9gknd 7623 4 this this DT cord-010119-t1x9gknd 7623 5 study study NN cord-010119-t1x9gknd 7623 6 was be VBD cord-010119-t1x9gknd 7623 7 to to TO cord-010119-t1x9gknd 7623 8 determine determine VB cord-010119-t1x9gknd 7623 9 if if IN cord-010119-t1x9gknd 7623 10 frequencies frequency NNS cord-010119-t1x9gknd 7623 11 of of IN cord-010119-t1x9gknd 7623 12 red red JJ cord-010119-t1x9gknd 7623 13 cell cell NN cord-010119-t1x9gknd 7623 14 antibodies antibody NNS cord-010119-t1x9gknd 7623 15 differed differ VBD cord-010119-t1x9gknd 7623 16 between between IN cord-010119-t1x9gknd 7623 17 geographically geographically RB cord-010119-t1x9gknd 7623 18 distinct distinct JJ cord-010119-t1x9gknd 7623 19 regions region NNS cord-010119-t1x9gknd 7623 20 within within IN cord-010119-t1x9gknd 7623 21 the the DT cord-010119-t1x9gknd 7623 22 continental continental JJ cord-010119-t1x9gknd 7623 23 United United NNP cord-010119-t1x9gknd 7623 24 States States NNP cord-010119-t1x9gknd 7623 25 . . . cord-010119-t1x9gknd 7624 1 Study Study NNP cord-010119-t1x9gknd 7624 2 Design/ Design/ NNP cord-010119-t1x9gknd 7624 3 Method Method NNP cord-010119-t1x9gknd 7624 4 : : : cord-010119-t1x9gknd 7625 1 The the DT cord-010119-t1x9gknd 7625 2 aim aim NN cord-010119-t1x9gknd 7625 3 of of IN cord-010119-t1x9gknd 7625 4 this this DT cord-010119-t1x9gknd 7625 5 retrospective retrospective JJ cord-010119-t1x9gknd 7625 6 study study NN cord-010119-t1x9gknd 7625 7 was be VBD cord-010119-t1x9gknd 7625 8 to to TO cord-010119-t1x9gknd 7625 9 evaluate evaluate VB cord-010119-t1x9gknd 7625 10 a a DT cord-010119-t1x9gknd 7625 11 cohort cohort NN cord-010119-t1x9gknd 7625 12 of of IN cord-010119-t1x9gknd 7625 13 prenatal prenatal JJ cord-010119-t1x9gknd 7625 14 patients patient NNS cord-010119-t1x9gknd 7625 15 ( ( -LRB- cord-010119-t1x9gknd 7625 16 n n NN cord-010119-t1x9gknd 7625 17 5 5 CD cord-010119-t1x9gknd 7625 18 756,221 756,221 CD cord-010119-t1x9gknd 7625 19 ) ) -RRB- cord-010119-t1x9gknd 7625 20 drawn draw VBN cord-010119-t1x9gknd 7625 21 between between IN cord-010119-t1x9gknd 7625 22 July July NNP cord-010119-t1x9gknd 7625 23 1 1 CD cord-010119-t1x9gknd 7625 24 , , , cord-010119-t1x9gknd 7625 25 2013 2013 CD cord-010119-t1x9gknd 7625 26 and and CC cord-010119-t1x9gknd 7625 27 June June NNP cord-010119-t1x9gknd 7625 28 30 30 CD cord-010119-t1x9gknd 7625 29 , , , cord-010119-t1x9gknd 7625 30 2014 2014 CD cord-010119-t1x9gknd 7625 31 . . . cord-010119-t1x9gknd 7626 1 These these DT cord-010119-t1x9gknd 7626 2 patients patient NNS cord-010119-t1x9gknd 7626 3 were be VBD cord-010119-t1x9gknd 7626 4 divided divide VBN cord-010119-t1x9gknd 7626 5 into into IN cord-010119-t1x9gknd 7626 6 United United NNP cord-010119-t1x9gknd 7626 7 States States NNP cord-010119-t1x9gknd 7626 8 Census Census NNP cord-010119-t1x9gknd 7626 9 Bureau Bureau NNP cord-010119-t1x9gknd 7626 10 regional regional JJ cord-010119-t1x9gknd 7626 11 and and CC cord-010119-t1x9gknd 7626 12 divisional divisional JJ cord-010119-t1x9gknd 7626 13 categories category NNS cord-010119-t1x9gknd 7626 14 according accord VBG cord-010119-t1x9gknd 7626 15 to to IN cord-010119-t1x9gknd 7626 16 their -PRON- PRP$ cord-010119-t1x9gknd 7626 17 place place NN cord-010119-t1x9gknd 7626 18 of of IN cord-010119-t1x9gknd 7626 19 residence residence NN cord-010119-t1x9gknd 7626 20 . . . cord-010119-t1x9gknd 7627 1 Prenatal prenatal JJ cord-010119-t1x9gknd 7627 2 blood blood NN cord-010119-t1x9gknd 7627 3 work work NN cord-010119-t1x9gknd 7627 4 was be VBD cord-010119-t1x9gknd 7627 5 collected collect VBN cord-010119-t1x9gknd 7627 6 which which WDT cord-010119-t1x9gknd 7627 7 included include VBD cord-010119-t1x9gknd 7627 8 an an DT cord-010119-t1x9gknd 7627 9 ABO ABO NNP cord-010119-t1x9gknd 7627 10 , , , cord-010119-t1x9gknd 7627 11 Rh(D Rh(D NNP cord-010119-t1x9gknd 7627 12 ) ) -RRB- cord-010119-t1x9gknd 7627 13 and and CC cord-010119-t1x9gknd 7627 14 a a DT cord-010119-t1x9gknd 7627 15 screen screen NN cord-010119-t1x9gknd 7627 16 for for IN cord-010119-t1x9gknd 7627 17 unexpected unexpected JJ cord-010119-t1x9gknd 7627 18 alloantibodies alloantibody NNS cord-010119-t1x9gknd 7627 19 . . . cord-010119-t1x9gknd 7628 1 Samples sample NNS cord-010119-t1x9gknd 7628 2 found find VBN cord-010119-t1x9gknd 7628 3 to to TO cord-010119-t1x9gknd 7628 4 be be VB cord-010119-t1x9gknd 7628 5 positive positive JJ cord-010119-t1x9gknd 7628 6 for for IN cord-010119-t1x9gknd 7628 7 red red JJ cord-010119-t1x9gknd 7628 8 cell cell NN cord-010119-t1x9gknd 7628 9 antibodies antibody NNS cord-010119-t1x9gknd 7628 10 were be VBD cord-010119-t1x9gknd 7628 11 sent send VBN cord-010119-t1x9gknd 7628 12 to to IN cord-010119-t1x9gknd 7628 13 one one CD cord-010119-t1x9gknd 7628 14 of of IN cord-010119-t1x9gknd 7628 15 nine nine CD cord-010119-t1x9gknd 7628 16 regional regional JJ cord-010119-t1x9gknd 7628 17 laboratories laboratory NNS cord-010119-t1x9gknd 7628 18 for for IN cord-010119-t1x9gknd 7628 19 identification identification NN cord-010119-t1x9gknd 7628 20 . . . cord-010119-t1x9gknd 7629 1 Results/ results/ IN cord-010119-t1x9gknd 7629 2 Finding finding NN cord-010119-t1x9gknd 7629 3 : : : cord-010119-t1x9gknd 7630 1 In in IN cord-010119-t1x9gknd 7630 2 total total JJ cord-010119-t1x9gknd 7630 3 , , , cord-010119-t1x9gknd 7630 4 11,647 11,647 CD cord-010119-t1x9gknd 7630 5 patients patient NNS cord-010119-t1x9gknd 7630 6 were be VBD cord-010119-t1x9gknd 7630 7 found find VBN cord-010119-t1x9gknd 7630 8 to to TO cord-010119-t1x9gknd 7630 9 possess possess VB cord-010119-t1x9gknd 7630 10 clinically clinically RB cord-010119-t1x9gknd 7630 11 significant significant JJ cord-010119-t1x9gknd 7630 12 red red JJ cord-010119-t1x9gknd 7630 13 cell cell NN cord-010119-t1x9gknd 7630 14 antibodies antibody NNS cord-010119-t1x9gknd 7630 15 for for IN cord-010119-t1x9gknd 7630 16 an an DT cord-010119-t1x9gknd 7630 17 overall overall JJ cord-010119-t1x9gknd 7630 18 incidence incidence NN cord-010119-t1x9gknd 7630 19 of of IN cord-010119-t1x9gknd 7630 20 1.5 1.5 CD cord-010119-t1x9gknd 7630 21 percent percent NN cord-010119-t1x9gknd 7630 22 . . . cord-010119-t1x9gknd 7631 1 The the DT cord-010119-t1x9gknd 7631 2 three three CD cord-010119-t1x9gknd 7631 3 most most RBS cord-010119-t1x9gknd 7631 4 commonly commonly RB cord-010119-t1x9gknd 7631 5 encountered encounter VBN cord-010119-t1x9gknd 7631 6 antibodies antibody NNS cord-010119-t1x9gknd 7631 7 were be VBD cord-010119-t1x9gknd 7631 8 anti anti JJ cord-010119-t1x9gknd 7631 9 - - JJ cord-010119-t1x9gknd 7631 10 D d JJ cord-010119-t1x9gknd 7631 11 ( ( -LRB- cord-010119-t1x9gknd 7631 12 n n NN cord-010119-t1x9gknd 7631 13 5 5 CD cord-010119-t1x9gknd 7631 14 7639 7639 CD cord-010119-t1x9gknd 7631 15 ) ) -RRB- cord-010119-t1x9gknd 7631 16 63.1 63.1 CD cord-010119-t1x9gknd 7631 17 % % NN cord-010119-t1x9gknd 7631 18 , , , cord-010119-t1x9gknd 7631 19 anti anti JJ cord-010119-t1x9gknd 7631 20 - - NNP cord-010119-t1x9gknd 7631 21 M M NNP cord-010119-t1x9gknd 7631 22 ( ( -LRB- cord-010119-t1x9gknd 7631 23 n n NN cord-010119-t1x9gknd 7631 24 5 5 CD cord-010119-t1x9gknd 7631 25 1288 1288 CD cord-010119-t1x9gknd 7631 26 ) ) -RRB- cord-010119-t1x9gknd 7631 27 0.6 0.6 CD cord-010119-t1x9gknd 7631 28 % % NN cord-010119-t1x9gknd 7631 29 , , , cord-010119-t1x9gknd 7631 30 and and CC cord-010119-t1x9gknd 7631 31 anti anti JJ cord-010119-t1x9gknd 7631 32 - - JJ cord-010119-t1x9gknd 7631 33 E e JJ cord-010119-t1x9gknd 7631 34 ( ( -LRB- cord-010119-t1x9gknd 7631 35 n n NN cord-010119-t1x9gknd 7631 36 5 5 CD cord-010119-t1x9gknd 7631 37 1227 1227 CD cord-010119-t1x9gknd 7631 38 ) ) -RRB- cord-010119-t1x9gknd 7631 39 with with IN cord-010119-t1x9gknd 7631 40 a a DT cord-010119-t1x9gknd 7631 41 frequency frequency NN cord-010119-t1x9gknd 7631 42 of of IN cord-010119-t1x9gknd 7631 43 10.1 10.1 CD cord-010119-t1x9gknd 7631 44 % % NN cord-010119-t1x9gknd 7631 45 . . . cord-010119-t1x9gknd 7632 1 A a DT cord-010119-t1x9gknd 7632 2 total total NN cord-010119-t1x9gknd 7632 3 of of IN cord-010119-t1x9gknd 7632 4 455 455 CD cord-010119-t1x9gknd 7632 5 ( ( -LRB- cord-010119-t1x9gknd 7632 6 3.9 3.9 CD cord-010119-t1x9gknd 7632 7 % % NN cord-010119-t1x9gknd 7632 8 ) ) -RRB- cord-010119-t1x9gknd 7633 1 prenatal prenatal JJ cord-010119-t1x9gknd 7633 2 women woman NNS cord-010119-t1x9gknd 7633 3 were be VBD cord-010119-t1x9gknd 7633 4 found find VBN cord-010119-t1x9gknd 7633 5 to to TO cord-010119-t1x9gknd 7633 6 possess possess VB cord-010119-t1x9gknd 7633 7 two two CD cord-010119-t1x9gknd 7633 8 or or CC cord-010119-t1x9gknd 7633 9 more more JJR cord-010119-t1x9gknd 7633 10 antibodies antibody NNS cord-010119-t1x9gknd 7633 11 . . . cord-010119-t1x9gknd 7634 1 In in IN cord-010119-t1x9gknd 7634 2 general general JJ cord-010119-t1x9gknd 7634 3 , , , cord-010119-t1x9gknd 7634 4 the the DT cord-010119-t1x9gknd 7634 5 combination combination NN cord-010119-t1x9gknd 7634 6 of of IN cord-010119-t1x9gknd 7634 7 anti anti JJ cord-010119-t1x9gknd 7634 8 - - JJ cord-010119-t1x9gknd 7634 9 D d JJ cord-010119-t1x9gknd 7634 10 and and CC cord-010119-t1x9gknd 7634 11 anti anti JJ cord-010119-t1x9gknd 7634 12 - - NN cord-010119-t1x9gknd 7634 13 C C NNP cord-010119-t1x9gknd 7634 14 proved prove VBD cord-010119-t1x9gknd 7634 15 to to TO cord-010119-t1x9gknd 7634 16 be be VB cord-010119-t1x9gknd 7634 17 the the DT cord-010119-t1x9gknd 7634 18 most most RBS cord-010119-t1x9gknd 7634 19 common common JJ cord-010119-t1x9gknd 7634 20 , , , cord-010119-t1x9gknd 7634 21 with with IN cord-010119-t1x9gknd 7634 22 182 182 CD cord-010119-t1x9gknd 7634 23 instances instance NNS cord-010119-t1x9gknd 7634 24 ( ( -LRB- cord-010119-t1x9gknd 7634 25 40.0 40.0 CD cord-010119-t1x9gknd 7634 26 % % NN cord-010119-t1x9gknd 7634 27 ) ) -RRB- cord-010119-t1x9gknd 7634 28 followed follow VBN cord-010119-t1x9gknd 7634 29 by by IN cord-010119-t1x9gknd 7634 30 anti anti JJ cord-010119-t1x9gknd 7634 31 - - JJ cord-010119-t1x9gknd 7634 32 E e JJ cord-010119-t1x9gknd 7634 33 and and CC cord-010119-t1x9gknd 7634 34 anti anti JJ cord-010119-t1x9gknd 7634 35 - - NN cord-010119-t1x9gknd 7634 36 c c JJ cord-010119-t1x9gknd 7634 37 with with IN cord-010119-t1x9gknd 7634 38 79 79 CD cord-010119-t1x9gknd 7634 39 ( ( -LRB- cord-010119-t1x9gknd 7634 40 17.4 17.4 CD cord-010119-t1x9gknd 7634 41 % % NN cord-010119-t1x9gknd 7634 42 ) ) -RRB- cord-010119-t1x9gknd 7634 43 , , , cord-010119-t1x9gknd 7634 44 and and CC cord-010119-t1x9gknd 7634 45 anti anti JJ cord-010119-t1x9gknd 7634 46 - - NNP cord-010119-t1x9gknd 7634 47 C c JJ cord-010119-t1x9gknd 7634 48 , , , cord-010119-t1x9gknd 7634 49 anti anti NN cord-010119-t1x9gknd 7634 50 - - NN cord-010119-t1x9gknd 7634 51 e e JJ cord-010119-t1x9gknd 7634 52 with with IN cord-010119-t1x9gknd 7634 53 26 26 CD cord-010119-t1x9gknd 7634 54 ( ( -LRB- cord-010119-t1x9gknd 7634 55 5.7 5.7 CD cord-010119-t1x9gknd 7634 56 % % NN cord-010119-t1x9gknd 7634 57 ) ) -RRB- cord-010119-t1x9gknd 7634 58 . . . cord-010119-t1x9gknd 7635 1 Of of IN cord-010119-t1x9gknd 7635 2 the the DT cord-010119-t1x9gknd 7635 3 multiple multiple JJ cord-010119-t1x9gknd 7635 4 antibodies antibody NNS cord-010119-t1x9gknd 7635 5 identified identify VBN cord-010119-t1x9gknd 7635 6 , , , cord-010119-t1x9gknd 7635 7 435 435 CD cord-010119-t1x9gknd 7635 8 ( ( -LRB- cord-010119-t1x9gknd 7635 9 95.6 95.6 CD cord-010119-t1x9gknd 7635 10 % % NN cord-010119-t1x9gknd 7635 11 ) ) -RRB- cord-010119-t1x9gknd 7635 12 included include VBD cord-010119-t1x9gknd 7635 13 at at IN cord-010119-t1x9gknd 7635 14 least least RBS cord-010119-t1x9gknd 7635 15 one one CD cord-010119-t1x9gknd 7635 16 antibody antibody NN cord-010119-t1x9gknd 7635 17 from from IN cord-010119-t1x9gknd 7635 18 the the DT cord-010119-t1x9gknd 7635 19 Rh Rh NNP cord-010119-t1x9gknd 7635 20 blood blood NN cord-010119-t1x9gknd 7635 21 group group NN cord-010119-t1x9gknd 7635 22 . . . cord-010119-t1x9gknd 7636 1 The the DT cord-010119-t1x9gknd 7636 2 South South NNP cord-010119-t1x9gknd 7636 3 region region NN cord-010119-t1x9gknd 7636 4 had have VBD cord-010119-t1x9gknd 7636 5 the the DT cord-010119-t1x9gknd 7636 6 largest large JJS cord-010119-t1x9gknd 7636 7 number number NN cord-010119-t1x9gknd 7636 8 of of IN cord-010119-t1x9gknd 7636 9 antibodies antibody NNS cord-010119-t1x9gknd 7636 10 identified identify VBN cord-010119-t1x9gknd 7636 11 with with IN cord-010119-t1x9gknd 7636 12 7474 7474 CD cord-010119-t1x9gknd 7636 13 or or CC cord-010119-t1x9gknd 7636 14 61.8 61.8 CD cord-010119-t1x9gknd 7636 15 % % NN cord-010119-t1x9gknd 7636 16 of of IN cord-010119-t1x9gknd 7636 17 the the DT cord-010119-t1x9gknd 7636 18 total total NN cord-010119-t1x9gknd 7636 19 . . . cord-010119-t1x9gknd 7637 1 The the DT cord-010119-t1x9gknd 7637 2 West West NNP cord-010119-t1x9gknd 7637 3 had have VBD cord-010119-t1x9gknd 7637 4 2111 2111 CD cord-010119-t1x9gknd 7637 5 ( ( -LRB- cord-010119-t1x9gknd 7637 6 17.4 17.4 CD cord-010119-t1x9gknd 7637 7 % % NN cord-010119-t1x9gknd 7637 8 ) ) -RRB- cord-010119-t1x9gknd 7637 9 , , , cord-010119-t1x9gknd 7637 10 the the DT cord-010119-t1x9gknd 7637 11 Midwest Midwest NNP cord-010119-t1x9gknd 7637 12 1538 1538 CD cord-010119-t1x9gknd 7637 13 ( ( -LRB- cord-010119-t1x9gknd 7637 14 12.7 12.7 CD cord-010119-t1x9gknd 7637 15 % % NN cord-010119-t1x9gknd 7637 16 ) ) -RRB- cord-010119-t1x9gknd 7637 17 and and CC cord-010119-t1x9gknd 7637 18 the the DT cord-010119-t1x9gknd 7637 19 Northeast Northeast NNP cord-010119-t1x9gknd 7637 20 with with IN cord-010119-t1x9gknd 7637 21 979 979 CD cord-010119-t1x9gknd 7637 22 ( ( -LRB- cord-010119-t1x9gknd 7637 23 8.1 8.1 CD cord-010119-t1x9gknd 7637 24 % % NN cord-010119-t1x9gknd 7637 25 ) ) -RRB- cord-010119-t1x9gknd 7637 26 . . . cord-010119-t1x9gknd 7638 1 A a DT cord-010119-t1x9gknd 7638 2 contingency contingency NN cord-010119-t1x9gknd 7638 3 table table NN cord-010119-t1x9gknd 7638 4 , , , cord-010119-t1x9gknd 7638 5 using use VBG cord-010119-t1x9gknd 7638 6 the the DT cord-010119-t1x9gknd 7638 7 two two CD cord-010119-t1x9gknd 7638 8 - - HYPH cord-010119-t1x9gknd 7638 9 sided sided JJ cord-010119-t1x9gknd 7638 10 Fisher Fisher NNP cord-010119-t1x9gknd 7638 11 's 's POS cord-010119-t1x9gknd 7638 12 exact exact JJ cord-010119-t1x9gknd 7638 13 test test NN cord-010119-t1x9gknd 7638 14 , , , cord-010119-t1x9gknd 7638 15 was be VBD cord-010119-t1x9gknd 7638 16 performed perform VBN cord-010119-t1x9gknd 7638 17 comparing compare VBG cord-010119-t1x9gknd 7638 18 the the DT cord-010119-t1x9gknd 7638 19 Northeast Northeast NNP cord-010119-t1x9gknd 7638 20 , , , cord-010119-t1x9gknd 7638 21 South South NNP cord-010119-t1x9gknd 7638 22 , , , cord-010119-t1x9gknd 7638 23 Midwest Midwest NNP cord-010119-t1x9gknd 7638 24 and and CC cord-010119-t1x9gknd 7638 25 West West NNP cord-010119-t1x9gknd 7638 26 regions region NNS cord-010119-t1x9gknd 7638 27 . . . cord-010119-t1x9gknd 7639 1 The the DT cord-010119-t1x9gknd 7639 2 p p NN cord-010119-t1x9gknd 7639 3 value value NN cord-010119-t1x9gknd 7639 4 of of IN cord-010119-t1x9gknd 7639 5 anti anti JJ cord-010119-t1x9gknd 7639 6 - - JJ cord-010119-t1x9gknd 7639 7 D d JJ cord-010119-t1x9gknd 7639 8 was be VBD cord-010119-t1x9gknd 7639 9 calculated calculate VBN cord-010119-t1x9gknd 7639 10 to to TO cord-010119-t1x9gknd 7639 11 determine determine VB cord-010119-t1x9gknd 7639 12 nonrandom nonrandom JJ cord-010119-t1x9gknd 7639 13 associations association NNS cord-010119-t1x9gknd 7639 14 and and CC cord-010119-t1x9gknd 7639 15 values value NNS cord-010119-t1x9gknd 7639 16 of of IN cord-010119-t1x9gknd 7639 17 0.05 0.05 CD cord-010119-t1x9gknd 7639 18 and and CC cord-010119-t1x9gknd 7639 19 below below RB cord-010119-t1x9gknd 7639 20 was be VBD cord-010119-t1x9gknd 7639 21 deemed deem VBN cord-010119-t1x9gknd 7639 22 significant significant JJ cord-010119-t1x9gknd 7639 23 from from IN cord-010119-t1x9gknd 7639 24 a a DT cord-010119-t1x9gknd 7639 25 region region NN cord-010119-t1x9gknd 7639 26 - - HYPH cord-010119-t1x9gknd 7639 27 to to IN cord-010119-t1x9gknd 7639 28 - - HYPH cord-010119-t1x9gknd 7639 29 region region NN cord-010119-t1x9gknd 7639 30 perspective perspective NN cord-010119-t1x9gknd 7639 31 . . . cord-010119-t1x9gknd 7640 1 With with IN cord-010119-t1x9gknd 7640 2 regard regard NN cord-010119-t1x9gknd 7640 3 to to IN cord-010119-t1x9gknd 7640 4 anti anti JJ cord-010119-t1x9gknd 7640 5 - - JJ cord-010119-t1x9gknd 7640 6 D d JJ cord-010119-t1x9gknd 7640 7 , , , cord-010119-t1x9gknd 7640 8 the the DT cord-010119-t1x9gknd 7640 9 Pacific Pacific NNP cord-010119-t1x9gknd 7640 10 division division NN cord-010119-t1x9gknd 7640 11 comprised comprise VBN cord-010119-t1x9gknd 7640 12 of of IN cord-010119-t1x9gknd 7640 13 California California NNP cord-010119-t1x9gknd 7640 14 , , , cord-010119-t1x9gknd 7640 15 Oregon Oregon NNP cord-010119-t1x9gknd 7640 16 , , , cord-010119-t1x9gknd 7640 17 Washington Washington NNP cord-010119-t1x9gknd 7640 18 , , , cord-010119-t1x9gknd 7640 19 and and CC cord-010119-t1x9gknd 7640 20 Alaska Alaska NNP cord-010119-t1x9gknd 7640 21 , , , cord-010119-t1x9gknd 7640 22 had have VBD cord-010119-t1x9gknd 7640 23 p p NN cord-010119-t1x9gknd 7640 24 values value NNS cord-010119-t1x9gknd 7640 25 below below IN cord-010119-t1x9gknd 7640 26 the the DT cord-010119-t1x9gknd 7640 27 0.05 0.05 CD cord-010119-t1x9gknd 7640 28 thresholds threshold NNS cord-010119-t1x9gknd 7640 29 when when WRB cord-010119-t1x9gknd 7640 30 compared compare VBN cord-010119-t1x9gknd 7640 31 against against IN cord-010119-t1x9gknd 7640 32 seven seven CD cord-010119-t1x9gknd 7640 33 of of IN cord-010119-t1x9gknd 7640 34 the the DT cord-010119-t1x9gknd 7640 35 eight eight CD cord-010119-t1x9gknd 7640 36 other other JJ cord-010119-t1x9gknd 7640 37 divisions division NNS cord-010119-t1x9gknd 7640 38 . . . cord-010119-t1x9gknd 7641 1 The the DT cord-010119-t1x9gknd 7641 2 West West NNP cord-010119-t1x9gknd 7641 3 South South NNP cord-010119-t1x9gknd 7641 4 Central Central NNP cord-010119-t1x9gknd 7641 5 division division NN cord-010119-t1x9gknd 7641 6 ( ( -LRB- cord-010119-t1x9gknd 7641 7 Texas Texas NNP cord-010119-t1x9gknd 7641 8 , , , cord-010119-t1x9gknd 7641 9 Oklahoma Oklahoma NNP cord-010119-t1x9gknd 7641 10 , , , cord-010119-t1x9gknd 7641 11 Arkansas Arkansas NNP cord-010119-t1x9gknd 7641 12 , , , cord-010119-t1x9gknd 7641 13 and and CC cord-010119-t1x9gknd 7641 14 Louisiana Louisiana NNP cord-010119-t1x9gknd 7641 15 ) ) -RRB- cord-010119-t1x9gknd 7641 16 did do VBD cord-010119-t1x9gknd 7641 17 not not RB cord-010119-t1x9gknd 7641 18 show show VB cord-010119-t1x9gknd 7641 19 statistically statistically RB cord-010119-t1x9gknd 7641 20 significant significant JJ cord-010119-t1x9gknd 7641 21 results result NNS cord-010119-t1x9gknd 7641 22 when when WRB cord-010119-t1x9gknd 7641 23 compared compare VBN cord-010119-t1x9gknd 7641 24 against against IN cord-010119-t1x9gknd 7641 25 the the DT cord-010119-t1x9gknd 7641 26 Pacific Pacific NNP cord-010119-t1x9gknd 7641 27 division division NN cord-010119-t1x9gknd 7641 28 ( ( -LRB- cord-010119-t1x9gknd 7641 29 p p NN cord-010119-t1x9gknd 7641 30 5 5 CD cord-010119-t1x9gknd 7641 31 0.17 0.17 CD cord-010119-t1x9gknd 7641 32 ) ) -RRB- cord-010119-t1x9gknd 7641 33 . . . cord-010119-t1x9gknd 7642 1 Conclusion conclusion NN cord-010119-t1x9gknd 7642 2 : : : cord-010119-t1x9gknd 7643 1 Depending depend VBG cord-010119-t1x9gknd 7643 2 upon upon IN cord-010119-t1x9gknd 7643 3 the the DT cord-010119-t1x9gknd 7643 4 antibody antibody NN cord-010119-t1x9gknd 7643 5 , , , cord-010119-t1x9gknd 7643 6 statistically statistically RB cord-010119-t1x9gknd 7643 7 significant significant JJ cord-010119-t1x9gknd 7643 8 variations variation NNS cord-010119-t1x9gknd 7643 9 between between IN cord-010119-t1x9gknd 7643 10 geographical geographical JJ cord-010119-t1x9gknd 7643 11 regions region NNS cord-010119-t1x9gknd 7643 12 and and CC cord-010119-t1x9gknd 7643 13 divisions division NNS cord-010119-t1x9gknd 7643 14 within within IN cord-010119-t1x9gknd 7643 15 the the DT cord-010119-t1x9gknd 7643 16 United United NNP cord-010119-t1x9gknd 7643 17 States States NNP cord-010119-t1x9gknd 7643 18 were be VBD cord-010119-t1x9gknd 7643 19 observed observe VBN cord-010119-t1x9gknd 7643 20 . . . cord-010119-t1x9gknd 7644 1 This this DT cord-010119-t1x9gknd 7644 2 relationship relationship NN cord-010119-t1x9gknd 7644 3 between between IN cord-010119-t1x9gknd 7644 4 antibody antibody NN cord-010119-t1x9gknd 7644 5 and and CC cord-010119-t1x9gknd 7644 6 locality locality NN cord-010119-t1x9gknd 7644 7 requires require VBZ cord-010119-t1x9gknd 7644 8 further further JJ cord-010119-t1x9gknd 7644 9 investigation investigation NN cord-010119-t1x9gknd 7644 10 but but CC cord-010119-t1x9gknd 7644 11 may may MD cord-010119-t1x9gknd 7644 12 be be VB cord-010119-t1x9gknd 7644 13 attributed attribute VBN cord-010119-t1x9gknd 7644 14 to to IN cord-010119-t1x9gknd 7644 15 the the DT cord-010119-t1x9gknd 7644 16 presence presence NN cord-010119-t1x9gknd 7644 17 or or CC cord-010119-t1x9gknd 7644 18 absence absence NN cord-010119-t1x9gknd 7644 19 of of IN cord-010119-t1x9gknd 7644 20 red red JJ cord-010119-t1x9gknd 7644 21 cell cell NN cord-010119-t1x9gknd 7644 22 antigens antigen NNS cord-010119-t1x9gknd 7644 23 among among IN cord-010119-t1x9gknd 7644 24 different different JJ cord-010119-t1x9gknd 7644 25 racial racial JJ cord-010119-t1x9gknd 7644 26 and and CC cord-010119-t1x9gknd 7644 27 ethical ethical JJ cord-010119-t1x9gknd 7644 28 populations population NNS cord-010119-t1x9gknd 7644 29 . . . cord-010119-t1x9gknd 7645 1 Reduction reduction NN cord-010119-t1x9gknd 7645 2 in in IN cord-010119-t1x9gknd 7645 3 Repeat repeat NN cord-010119-t1x9gknd 7645 4 Testing Testing NNP cord-010119-t1x9gknd 7645 5 Using use VBG cord-010119-t1x9gknd 7645 6 Gel Gel NNP cord-010119-t1x9gknd 7645 7 Technology Technology NNP cord-010119-t1x9gknd 7645 8 Amy Amy NNP cord-010119-t1x9gknd 7645 9 Mata Mata NNP cord-010119-t1x9gknd 7645 10 * * NFP cord-010119-t1x9gknd 7645 11 1 1 CD cord-010119-t1x9gknd 7645 12 , , , cord-010119-t1x9gknd 7645 13 Lindsy Lindsy NNP cord-010119-t1x9gknd 7645 14 Rich Rich NNP cord-010119-t1x9gknd 7645 15 1 1 CD cord-010119-t1x9gknd 7645 16 , , , cord-010119-t1x9gknd 7645 17 Sherry Sherry NNP cord-010119-t1x9gknd 7645 18 Stern Stern NNP cord-010119-t1x9gknd 7645 19 1 1 CD cord-010119-t1x9gknd 7645 20 , , , cord-010119-t1x9gknd 7645 21 Sharon Sharon NNP cord-010119-t1x9gknd 7645 22 Wangen Wangen NNP cord-010119-t1x9gknd 7645 23 1 1 CD cord-010119-t1x9gknd 7645 24 and and CC cord-010119-t1x9gknd 7645 25 Camille Camille NNP cord-010119-t1x9gknd 7645 26 van van NNP cord-010119-t1x9gknd 7645 27 Buskirk Buskirk NNP cord-010119-t1x9gknd 7645 28 2 2 CD cord-010119-t1x9gknd 7645 29 . . . cord-010119-t1x9gknd 7646 1 1 1 CD cord-010119-t1x9gknd 7646 2 Mayo Mayo NNP cord-010119-t1x9gknd 7646 3 Clinic Clinic NNP cord-010119-t1x9gknd 7646 4 , , , cord-010119-t1x9gknd 7646 5 2 2 CD cord-010119-t1x9gknd 7646 6 Mayo Mayo NNP cord-010119-t1x9gknd 7646 7 Clinic Clinic NNP cord-010119-t1x9gknd 7646 8 Rochester Rochester NNP cord-010119-t1x9gknd 7646 9 Background Background NNP cord-010119-t1x9gknd 7646 10 / / SYM cord-010119-t1x9gknd 7646 11 Case Case NNP cord-010119-t1x9gknd 7646 12 Studies Studies NNPS cord-010119-t1x9gknd 7646 13 : : : cord-010119-t1x9gknd 7647 1 Our -PRON- PRP$ cord-010119-t1x9gknd 7647 2 institution institution NN cord-010119-t1x9gknd 7647 3 currently currently RB cord-010119-t1x9gknd 7647 4 uses use VBZ cord-010119-t1x9gknd 7647 5 the the DT cord-010119-t1x9gknd 7647 6 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7647 7 NEO NEO NNP cord-010119-t1x9gknd 7647 8 ( ( -LRB- cord-010119-t1x9gknd 7647 9 Immucor Immucor NNP cord-010119-t1x9gknd 7647 10 , , , cord-010119-t1x9gknd 7647 11 Inc. Inc. NNP cord-010119-t1x9gknd 7647 12 , , , cord-010119-t1x9gknd 7647 13 Norcross Norcross NNP cord-010119-t1x9gknd 7647 14 , , , cord-010119-t1x9gknd 7647 15 Georgia Georgia NNP cord-010119-t1x9gknd 7647 16 ) ) -RRB- cord-010119-t1x9gknd 7647 17 to to TO cord-010119-t1x9gknd 7647 18 perform perform VB cord-010119-t1x9gknd 7647 19 ABO ABO NNP cord-010119-t1x9gknd 7647 20 / / SYM cord-010119-t1x9gknd 7647 21 Rh Rh NNP cord-010119-t1x9gknd 7647 22 and and CC cord-010119-t1x9gknd 7647 23 antibody antibody NN cord-010119-t1x9gknd 7647 24 screen screen NN cord-010119-t1x9gknd 7647 25 ( ( -LRB- cord-010119-t1x9gknd 7647 26 ABSC ABSC NNP cord-010119-t1x9gknd 7647 27 ) ) -RRB- cord-010119-t1x9gknd 7647 28 testing testing NN cord-010119-t1x9gknd 7647 29 utilizing utilize VBG cord-010119-t1x9gknd 7647 30 solid solid JJ cord-010119-t1x9gknd 7647 31 phase phase NN cord-010119-t1x9gknd 7647 32 technology technology NN cord-010119-t1x9gknd 7647 33 . . . cord-010119-t1x9gknd 7648 1 When when WRB cord-010119-t1x9gknd 7648 2 results result NNS cord-010119-t1x9gknd 7648 3 are be VBP cord-010119-t1x9gknd 7648 4 unable unable JJ cord-010119-t1x9gknd 7648 5 to to TO cord-010119-t1x9gknd 7648 6 be be VB cord-010119-t1x9gknd 7648 7 obtained obtain VBN cord-010119-t1x9gknd 7648 8 from from IN cord-010119-t1x9gknd 7648 9 the the DT cord-010119-t1x9gknd 7648 10 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7648 11 NEO NEO NNP cord-010119-t1x9gknd 7648 12 , , , cord-010119-t1x9gknd 7648 13 testing testing NN cord-010119-t1x9gknd 7648 14 is be VBZ cord-010119-t1x9gknd 7648 15 repeated repeat VBN cord-010119-t1x9gknd 7648 16 on on IN cord-010119-t1x9gknd 7648 17 the the DT cord-010119-t1x9gknd 7648 18 manual manual JJ cord-010119-t1x9gknd 7648 19 testing testing NN cord-010119-t1x9gknd 7648 20 bench bench NN cord-010119-t1x9gknd 7648 21 using use VBG cord-010119-t1x9gknd 7648 22 tube tube NN cord-010119-t1x9gknd 7648 23 agglutination agglutination NN cord-010119-t1x9gknd 7648 24 . . . cord-010119-t1x9gknd 7649 1 This this DT cord-010119-t1x9gknd 7649 2 repeat repeat NN cord-010119-t1x9gknd 7649 3 testing testing NN cord-010119-t1x9gknd 7649 4 can can MD cord-010119-t1x9gknd 7649 5 lead lead VB cord-010119-t1x9gknd 7649 6 to to IN cord-010119-t1x9gknd 7649 7 significant significant JJ cord-010119-t1x9gknd 7649 8 expenses expense NNS cord-010119-t1x9gknd 7649 9 including include VBG cord-010119-t1x9gknd 7649 10 reagents reagent NNS cord-010119-t1x9gknd 7649 11 , , , cord-010119-t1x9gknd 7649 12 supplies supply NNS cord-010119-t1x9gknd 7649 13 , , , cord-010119-t1x9gknd 7649 14 and and CC cord-010119-t1x9gknd 7649 15 technologist technologist NN cord-010119-t1x9gknd 7649 16 time time NN cord-010119-t1x9gknd 7649 17 . . . cord-010119-t1x9gknd 7649 18 _SP cord-010119-t1x9gknd 7650 1 It -PRON- PRP cord-010119-t1x9gknd 7650 2 was be VBD cord-010119-t1x9gknd 7650 3 decided decide VBN cord-010119-t1x9gknd 7650 4 by by IN cord-010119-t1x9gknd 7650 5 leadership leadership NN cord-010119-t1x9gknd 7650 6 in in IN cord-010119-t1x9gknd 7650 7 our -PRON- PRP$ cord-010119-t1x9gknd 7650 8 laboratory laboratory NN cord-010119-t1x9gknd 7650 9 that that IN cord-010119-t1x9gknd 7650 10 it -PRON- PRP cord-010119-t1x9gknd 7650 11 would would MD cord-010119-t1x9gknd 7650 12 be be VB cord-010119-t1x9gknd 7650 13 beneficial beneficial JJ cord-010119-t1x9gknd 7650 14 to to TO cord-010119-t1x9gknd 7650 15 observe observe VB cord-010119-t1x9gknd 7650 16 how how WRB cord-010119-t1x9gknd 7650 17 other other JJ cord-010119-t1x9gknd 7650 18 methodologies methodology NNS cord-010119-t1x9gknd 7650 19 perform perform VBP cord-010119-t1x9gknd 7650 20 in in IN cord-010119-t1x9gknd 7650 21 this this DT cord-010119-t1x9gknd 7650 22 regard regard NN cord-010119-t1x9gknd 7650 23 . . . cord-010119-t1x9gknd 7651 1 A a DT cord-010119-t1x9gknd 7651 2 side side NN cord-010119-t1x9gknd 7651 3 - - HYPH cord-010119-t1x9gknd 7651 4 by by IN cord-010119-t1x9gknd 7651 5 - - HYPH cord-010119-t1x9gknd 7651 6 side side NN cord-010119-t1x9gknd 7651 7 evaluation evaluation NN cord-010119-t1x9gknd 7651 8 was be VBD cord-010119-t1x9gknd 7651 9 performed perform VBN cord-010119-t1x9gknd 7651 10 between between IN cord-010119-t1x9gknd 7651 11 the the DT cord-010119-t1x9gknd 7651 12 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7651 13 NEO NEO NNP cord-010119-t1x9gknd 7651 14 and and CC cord-010119-t1x9gknd 7651 15 the the DT cord-010119-t1x9gknd 7651 16 ORTHO ORTHO NNP cord-010119-t1x9gknd 7651 17 VISION VISION NNP cord-010119-t1x9gknd 7651 18 ( ( -LRB- cord-010119-t1x9gknd 7651 19 Ortho Ortho NNP cord-010119-t1x9gknd 7651 20 Clinical Clinical NNP cord-010119-t1x9gknd 7651 21 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 7651 22 , , , cord-010119-t1x9gknd 7651 23 Rochester Rochester NNP cord-010119-t1x9gknd 7651 24 NY NY NNP cord-010119-t1x9gknd 7651 25 ) ) -RRB- cord-010119-t1x9gknd 7651 26 to to TO cord-010119-t1x9gknd 7651 27 determine determine VB cord-010119-t1x9gknd 7651 28 if if IN cord-010119-t1x9gknd 7651 29 there there EX cord-010119-t1x9gknd 7651 30 was be VBD cord-010119-t1x9gknd 7651 31 a a DT cord-010119-t1x9gknd 7651 32 significant significant JJ cord-010119-t1x9gknd 7651 33 difference difference NN cord-010119-t1x9gknd 7651 34 in in IN cord-010119-t1x9gknd 7651 35 the the DT cord-010119-t1x9gknd 7651 36 amount amount NN cord-010119-t1x9gknd 7651 37 of of IN cord-010119-t1x9gknd 7651 38 repeat repeat NN cord-010119-t1x9gknd 7651 39 manual manual JJ cord-010119-t1x9gknd 7651 40 tube tube NN cord-010119-t1x9gknd 7651 41 testing testing NN cord-010119-t1x9gknd 7651 42 that that WDT cord-010119-t1x9gknd 7651 43 needed need VBD cord-010119-t1x9gknd 7651 44 to to TO cord-010119-t1x9gknd 7651 45 be be VB cord-010119-t1x9gknd 7651 46 performed perform VBN cord-010119-t1x9gknd 7651 47 . . . cord-010119-t1x9gknd 7652 1 The the DT cord-010119-t1x9gknd 7652 2 evaluation evaluation NN cord-010119-t1x9gknd 7652 3 looked look VBD cord-010119-t1x9gknd 7652 4 at at IN cord-010119-t1x9gknd 7652 5 ABO ABO NNP cord-010119-t1x9gknd 7652 6 / / SYM cord-010119-t1x9gknd 7652 7 Rh Rh NNP cord-010119-t1x9gknd 7652 8 and and CC cord-010119-t1x9gknd 7652 9 ABSC ABSC NNP cord-010119-t1x9gknd 7652 10 testing testing NN cord-010119-t1x9gknd 7652 11 as as IN cord-010119-t1x9gknd 7652 12 those those DT cord-010119-t1x9gknd 7652 13 are be VBP cord-010119-t1x9gknd 7652 14 the the DT cord-010119-t1x9gknd 7652 15 only only JJ cord-010119-t1x9gknd 7652 16 tests test NNS cord-010119-t1x9gknd 7652 17 that that WDT cord-010119-t1x9gknd 7652 18 are be VBP cord-010119-t1x9gknd 7652 19 currently currently RB cord-010119-t1x9gknd 7652 20 automated automate VBN cord-010119-t1x9gknd 7652 21 in in IN cord-010119-t1x9gknd 7652 22 our -PRON- PRP$ cord-010119-t1x9gknd 7652 23 laboratory laboratory NN cord-010119-t1x9gknd 7652 24 . . . cord-010119-t1x9gknd 7653 1 Study Study NNP cord-010119-t1x9gknd 7653 2 Design Design NNP cord-010119-t1x9gknd 7653 3 / / SYM cord-010119-t1x9gknd 7653 4 Method method NN cord-010119-t1x9gknd 7653 5 : : : cord-010119-t1x9gknd 7654 1 Thirty thirty CD cord-010119-t1x9gknd 7654 2 specimens specimen NNS cord-010119-t1x9gknd 7654 3 that that WDT cord-010119-t1x9gknd 7654 4 were be VBD cord-010119-t1x9gknd 7654 5 processed process VBN cord-010119-t1x9gknd 7654 6 on on IN cord-010119-t1x9gknd 7654 7 the the DT cord-010119-t1x9gknd 7654 8 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7654 9 NEO NEO NNP cord-010119-t1x9gknd 7654 10 and and CC cord-010119-t1x9gknd 7654 11 resulted result VBD cord-010119-t1x9gknd 7654 12 in in IN cord-010119-t1x9gknd 7654 13 No no DT cord-010119-t1x9gknd 7654 14 Type type NN cord-010119-t1x9gknd 7654 15 Determined determine VBN cord-010119-t1x9gknd 7654 16 ( ( -LRB- cord-010119-t1x9gknd 7654 17 NTD NTD NNP cord-010119-t1x9gknd 7654 18 ) ) -RRB- cord-010119-t1x9gknd 7654 19 for for IN cord-010119-t1x9gknd 7654 20 ABO ABO NNP cord-010119-t1x9gknd 7654 21 / / SYM cord-010119-t1x9gknd 7654 22 Rh Rh NNP cord-010119-t1x9gknd 7654 23 testing testing NN cord-010119-t1x9gknd 7654 24 were be VBD cord-010119-t1x9gknd 7654 25 selected select VBN cord-010119-t1x9gknd 7654 26 to to TO cord-010119-t1x9gknd 7654 27 be be VB cord-010119-t1x9gknd 7654 28 tested test VBN cord-010119-t1x9gknd 7654 29 on on IN cord-010119-t1x9gknd 7654 30 the the DT cord-010119-t1x9gknd 7654 31 ORTHO ORTHO NNP cord-010119-t1x9gknd 7654 32 VISION vision NN cord-010119-t1x9gknd 7654 33 . . . cord-010119-t1x9gknd 7655 1 Twenty twenty CD cord-010119-t1x9gknd 7655 2 - - HYPH cord-010119-t1x9gknd 7655 3 three three CD cord-010119-t1x9gknd 7655 4 specimens specimen NNS cord-010119-t1x9gknd 7655 5 that that WDT cord-010119-t1x9gknd 7655 6 were be VBD cord-010119-t1x9gknd 7655 7 processed process VBN cord-010119-t1x9gknd 7655 8 on on IN cord-010119-t1x9gknd 7655 9 the the DT cord-010119-t1x9gknd 7655 10 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7655 11 NEO NEO NNP cord-010119-t1x9gknd 7655 12 and and CC cord-010119-t1x9gknd 7655 13 produced produce VBD cord-010119-t1x9gknd 7655 14 positive positive JJ cord-010119-t1x9gknd 7655 15 results result NNS cord-010119-t1x9gknd 7655 16 for for IN cord-010119-t1x9gknd 7655 17 ABSC ABSC NNS cord-010119-t1x9gknd 7655 18 testing testing NN cord-010119-t1x9gknd 7655 19 were be VBD cord-010119-t1x9gknd 7655 20 selected select VBN cord-010119-t1x9gknd 7655 21 to to TO cord-010119-t1x9gknd 7655 22 be be VB cord-010119-t1x9gknd 7655 23 tested test VBN cord-010119-t1x9gknd 7655 24 on on IN cord-010119-t1x9gknd 7655 25 the the DT cord-010119-t1x9gknd 7655 26 ORTHO ORTHO NNP cord-010119-t1x9gknd 7655 27 VISION vision NN cord-010119-t1x9gknd 7655 28 . . . cord-010119-t1x9gknd 7656 1 All all DT cord-010119-t1x9gknd 7656 2 specimens specimen NNS cord-010119-t1x9gknd 7656 3 were be VBD cord-010119-t1x9gknd 7656 4 EDTA edta NN cord-010119-t1x9gknd 7656 5 tubes tube NNS cord-010119-t1x9gknd 7656 6 and and CC cord-010119-t1x9gknd 7656 7 were be VBD cord-010119-t1x9gknd 7656 8 collected collect VBN cord-010119-t1x9gknd 7656 9 within within IN cord-010119-t1x9gknd 7656 10 the the DT cord-010119-t1x9gknd 7656 11 previous previous JJ cord-010119-t1x9gknd 7656 12 4 4 CD cord-010119-t1x9gknd 7656 13 days day NNS cord-010119-t1x9gknd 7656 14 . . . cord-010119-t1x9gknd 7657 1 The the DT cord-010119-t1x9gknd 7657 2 timeframe timeframe NN cord-010119-t1x9gknd 7657 3 between between IN cord-010119-t1x9gknd 7657 4 when when WRB cord-010119-t1x9gknd 7657 5 the the DT cord-010119-t1x9gknd 7657 6 specimen specimen NN cord-010119-t1x9gknd 7657 7 was be VBD cord-010119-t1x9gknd 7657 8 tested test VBN cord-010119-t1x9gknd 7657 9 on on IN cord-010119-t1x9gknd 7657 10 the the DT cord-010119-t1x9gknd 7657 11 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7657 12 NEO NEO NNP cord-010119-t1x9gknd 7657 13 and and CC cord-010119-t1x9gknd 7657 14 the the DT cord-010119-t1x9gknd 7657 15 ORTHO ORTHO NNP cord-010119-t1x9gknd 7657 16 VISION VISION NNP cord-010119-t1x9gknd 7657 17 was be VBD cord-010119-t1x9gknd 7657 18 1 1 CD cord-010119-t1x9gknd 7657 19 to to IN cord-010119-t1x9gknd 7657 20 2 2 CD cord-010119-t1x9gknd 7657 21 days day NNS cord-010119-t1x9gknd 7657 22 . . . cord-010119-t1x9gknd 7658 1 Results result NNS cord-010119-t1x9gknd 7658 2 / / SYM cord-010119-t1x9gknd 7658 3 Finding finding NN cord-010119-t1x9gknd 7658 4 : : : cord-010119-t1x9gknd 7659 1 Of of IN cord-010119-t1x9gknd 7659 2 the the DT cord-010119-t1x9gknd 7659 3 30 30 CD cord-010119-t1x9gknd 7659 4 NTD NTD NNP cord-010119-t1x9gknd 7659 5 specimens specimen NNS cord-010119-t1x9gknd 7659 6 from from IN cord-010119-t1x9gknd 7659 7 the the DT cord-010119-t1x9gknd 7659 8 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7659 9 NEO NEO NNP cord-010119-t1x9gknd 7659 10 , , , cord-010119-t1x9gknd 7659 11 8 8 CD cord-010119-t1x9gknd 7659 12 resulted result VBD cord-010119-t1x9gknd 7659 13 in in IN cord-010119-t1x9gknd 7659 14 valid valid JJ cord-010119-t1x9gknd 7659 15 ABO ABO NNP cord-010119-t1x9gknd 7659 16 / / SYM cord-010119-t1x9gknd 7659 17 Rh Rh NNP cord-010119-t1x9gknd 7659 18 typings typing NNS cord-010119-t1x9gknd 7659 19 on on IN cord-010119-t1x9gknd 7659 20 the the DT cord-010119-t1x9gknd 7659 21 ORTHO ORTHO NNP cord-010119-t1x9gknd 7659 22 VISION vision NN cord-010119-t1x9gknd 7659 23 . . . cord-010119-t1x9gknd 7660 1 Three three CD cord-010119-t1x9gknd 7660 2 results result NNS cord-010119-t1x9gknd 7660 3 were be VBD cord-010119-t1x9gknd 7660 4 flagged flag VBN cord-010119-t1x9gknd 7660 5 indicating indicate VBG cord-010119-t1x9gknd 7660 6 possible possible JJ cord-010119-t1x9gknd 7660 7 extra extra JJ cord-010119-t1x9gknd 7660 8 reactivity reactivity NN cord-010119-t1x9gknd 7660 9 . . . cord-010119-t1x9gknd 7661 1 Upon upon IN cord-010119-t1x9gknd 7661 2 performing perform VBG cord-010119-t1x9gknd 7661 3 a a DT cord-010119-t1x9gknd 7661 4 visual visual JJ cord-010119-t1x9gknd 7661 5 review review NN cord-010119-t1x9gknd 7661 6 of of IN cord-010119-t1x9gknd 7661 7 all all DT cord-010119-t1x9gknd 7661 8 3 3 CD cord-010119-t1x9gknd 7661 9 results result NNS cord-010119-t1x9gknd 7661 10 , , , cord-010119-t1x9gknd 7661 11 it -PRON- PRP cord-010119-t1x9gknd 7661 12 was be VBD cord-010119-t1x9gknd 7661 13 determined determine VBN cord-010119-t1x9gknd 7661 14 that that IN cord-010119-t1x9gknd 7661 15 there there EX cord-010119-t1x9gknd 7661 16 was be VBD cord-010119-t1x9gknd 7661 17 no no DT cord-010119-t1x9gknd 7661 18 reactivity reactivity NN cord-010119-t1x9gknd 7661 19 and and CC cord-010119-t1x9gknd 7661 20 a a DT cord-010119-t1x9gknd 7661 21 valid valid JJ cord-010119-t1x9gknd 7661 22 result result NN cord-010119-t1x9gknd 7661 23 was be VBD cord-010119-t1x9gknd 7661 24 present present JJ cord-010119-t1x9gknd 7661 25 . . . cord-010119-t1x9gknd 7662 1 The the DT cord-010119-t1x9gknd 7662 2 other other JJ cord-010119-t1x9gknd 7662 3 19 19 CD cord-010119-t1x9gknd 7662 4 samples sample NNS cord-010119-t1x9gknd 7662 5 required require VBN cord-010119-t1x9gknd 7662 6 manual manual JJ cord-010119-t1x9gknd 7662 7 tube tube NN cord-010119-t1x9gknd 7662 8 testing testing NN cord-010119-t1x9gknd 7662 9 to to TO cord-010119-t1x9gknd 7662 10 interpret interpret VB cord-010119-t1x9gknd 7662 11 the the DT cord-010119-t1x9gknd 7662 12 ABO ABO NNP cord-010119-t1x9gknd 7662 13 / / SYM cord-010119-t1x9gknd 7662 14 Rh Rh NNP cord-010119-t1x9gknd 7662 15 and and CC cord-010119-t1x9gknd 7662 16 were be VBD cord-010119-t1x9gknd 7662 17 due due JJ cord-010119-t1x9gknd 7662 18 to to IN cord-010119-t1x9gknd 7662 19 mixed mixed JJ cord-010119-t1x9gknd 7662 20 field field NN cord-010119-t1x9gknd 7662 21 , , , cord-010119-t1x9gknd 7662 22 weak weak JJ cord-010119-t1x9gknd 7662 23 isoagglutinins isoagglutinin NNS cord-010119-t1x9gknd 7662 24 , , , cord-010119-t1x9gknd 7662 25 unexplained unexplained JJ cord-010119-t1x9gknd 7662 26 extra extra JJ cord-010119-t1x9gknd 7662 27 reactivity reactivity NN cord-010119-t1x9gknd 7662 28 , , , cord-010119-t1x9gknd 7662 29 and and CC cord-010119-t1x9gknd 7662 30 hemolysis hemolysis NN cord-010119-t1x9gknd 7662 31 . . . cord-010119-t1x9gknd 7663 1 Of of IN cord-010119-t1x9gknd 7663 2 the the DT cord-010119-t1x9gknd 7663 3 23 23 CD cord-010119-t1x9gknd 7663 4 ABSC ABSC NNP cord-010119-t1x9gknd 7663 5 specimens specimen NNS cord-010119-t1x9gknd 7663 6 that that WDT cord-010119-t1x9gknd 7663 7 were be VBD cord-010119-t1x9gknd 7663 8 resulted result VBN cord-010119-t1x9gknd 7663 9 out out RP cord-010119-t1x9gknd 7663 10 as as IN cord-010119-t1x9gknd 7663 11 positive positive JJ cord-010119-t1x9gknd 7663 12 on on IN cord-010119-t1x9gknd 7663 13 the the DT cord-010119-t1x9gknd 7663 14 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7663 15 NEO NEO NNP cord-010119-t1x9gknd 7663 16 , , , cord-010119-t1x9gknd 7663 17 11 11 CD cord-010119-t1x9gknd 7663 18 specimens specimen NNS cord-010119-t1x9gknd 7663 19 produced produce VBD cord-010119-t1x9gknd 7663 20 a a DT cord-010119-t1x9gknd 7663 21 negative negative JJ cord-010119-t1x9gknd 7663 22 result result NN cord-010119-t1x9gknd 7663 23 on on IN cord-010119-t1x9gknd 7663 24 the the DT cord-010119-t1x9gknd 7663 25 ORTHO ORTHO NNP cord-010119-t1x9gknd 7663 26 VISION VISION NNP cord-010119-t1x9gknd 7663 27 and and CC cord-010119-t1x9gknd 7663 28 were be VBD cord-010119-t1x9gknd 7663 29 confirmed confirm VBN cord-010119-t1x9gknd 7663 30 to to TO cord-010119-t1x9gknd 7663 31 be be VB cord-010119-t1x9gknd 7663 32 negative negative JJ cord-010119-t1x9gknd 7663 33 with with IN cord-010119-t1x9gknd 7663 34 manual manual JJ cord-010119-t1x9gknd 7663 35 tube tube NN cord-010119-t1x9gknd 7663 36 testing testing NN cord-010119-t1x9gknd 7663 37 using use VBG cord-010119-t1x9gknd 7663 38 PEG PEG NNP cord-010119-t1x9gknd 7663 39 as as IN cord-010119-t1x9gknd 7663 40 the the DT cord-010119-t1x9gknd 7663 41 enhancement enhancement NN cord-010119-t1x9gknd 7663 42 media medium NNS cord-010119-t1x9gknd 7663 43 . . . cord-010119-t1x9gknd 7664 1 One one CD cord-010119-t1x9gknd 7664 2 specimen specimen NN cord-010119-t1x9gknd 7664 3 was be VBD cord-010119-t1x9gknd 7664 4 flagged flag VBN cord-010119-t1x9gknd 7664 5 for for IN cord-010119-t1x9gknd 7664 6 fibrin fibrin NN cord-010119-t1x9gknd 7664 7 , , , cord-010119-t1x9gknd 7664 8 but but CC cord-010119-t1x9gknd 7664 9 upon upon IN cord-010119-t1x9gknd 7664 10 performing perform VBG cord-010119-t1x9gknd 7664 11 a a DT cord-010119-t1x9gknd 7664 12 visual visual JJ cord-010119-t1x9gknd 7664 13 review review NN cord-010119-t1x9gknd 7664 14 , , , cord-010119-t1x9gknd 7664 15 was be VBD cord-010119-t1x9gknd 7664 16 determined determine VBN cord-010119-t1x9gknd 7664 17 to to TO cord-010119-t1x9gknd 7664 18 be be VB cord-010119-t1x9gknd 7664 19 negative negative JJ cord-010119-t1x9gknd 7664 20 . . . cord-010119-t1x9gknd 7665 1 Nine nine CD cord-010119-t1x9gknd 7665 2 specimens specimen NNS cord-010119-t1x9gknd 7665 3 that that WDT cord-010119-t1x9gknd 7665 4 were be VBD cord-010119-t1x9gknd 7665 5 positive positive JJ cord-010119-t1x9gknd 7665 6 on on IN cord-010119-t1x9gknd 7665 7 the the DT cord-010119-t1x9gknd 7665 8 IMMUCOR IMMUCOR NNP cord-010119-t1x9gknd 7665 9 NEO NEO NNP cord-010119-t1x9gknd 7665 10 were be VBD cord-010119-t1x9gknd 7665 11 also also RB cord-010119-t1x9gknd 7665 12 positive positive JJ cord-010119-t1x9gknd 7665 13 on on IN cord-010119-t1x9gknd 7665 14 the the DT cord-010119-t1x9gknd 7665 15 ORTHO ORTHO NNP cord-010119-t1x9gknd 7665 16 VISION vision NN cord-010119-t1x9gknd 7665 17 . . . cord-010119-t1x9gknd 7666 1 One one CD cord-010119-t1x9gknd 7666 2 specimen specimen NN cord-010119-t1x9gknd 7666 3 proved prove VBD cord-010119-t1x9gknd 7666 4 to to TO cord-010119-t1x9gknd 7666 5 be be VB cord-010119-t1x9gknd 7666 6 an an DT cord-010119-t1x9gknd 7666 7 anti anti JJ cord-010119-t1x9gknd 7666 8 - - JJ cord-010119-t1x9gknd 7666 9 M M NNP cord-010119-t1x9gknd 7666 10 that that WDT cord-010119-t1x9gknd 7666 11 was be VBD cord-010119-t1x9gknd 7666 12 seen see VBN cord-010119-t1x9gknd 7666 13 in in IN cord-010119-t1x9gknd 7666 14 gel gel NN cord-010119-t1x9gknd 7666 15 but but CC cord-010119-t1x9gknd 7666 16 not not RB cord-010119-t1x9gknd 7666 17 in in IN cord-010119-t1x9gknd 7666 18 tube tube NN cord-010119-t1x9gknd 7666 19 and and CC cord-010119-t1x9gknd 7666 20 one one CD cord-010119-t1x9gknd 7666 21 specimen specimen NN cord-010119-t1x9gknd 7666 22 displayed display VBD cord-010119-t1x9gknd 7666 23 unexplained unexplained JJ cord-010119-t1x9gknd 7666 24 reactivity reactivity NN cord-010119-t1x9gknd 7666 25 in in IN cord-010119-t1x9gknd 7666 26 gel gel NN cord-010119-t1x9gknd 7666 27 as as IN cord-010119-t1x9gknd 7666 28 it -PRON- PRP cord-010119-t1x9gknd 7666 29 was be VBD cord-010119-t1x9gknd 7666 30 negative negative JJ cord-010119-t1x9gknd 7666 31 in in IN cord-010119-t1x9gknd 7666 32 tube tube NN cord-010119-t1x9gknd 7666 33 and and CC cord-010119-t1x9gknd 7666 34 all all DT cord-010119-t1x9gknd 7666 35 clinically clinically RB cord-010119-t1x9gknd 7666 36 significant significant JJ cord-010119-t1x9gknd 7666 37 antibodies antibody NNS cord-010119-t1x9gknd 7666 38 were be VBD cord-010119-t1x9gknd 7666 39 ruled rule VBN cord-010119-t1x9gknd 7666 40 out out RP cord-010119-t1x9gknd 7666 41 . . . cord-010119-t1x9gknd 7667 1 All all DT cord-010119-t1x9gknd 7667 2 showed show VBD cord-010119-t1x9gknd 7667 3 discrepant discrepant JJ cord-010119-t1x9gknd 7667 4 results result NNS cord-010119-t1x9gknd 7667 5 with with IN cord-010119-t1x9gknd 7667 6 monoclonal monoclonal JJ cord-010119-t1x9gknd 7667 7 anti anti JJ cord-010119-t1x9gknd 7667 8 - - JJ cord-010119-t1x9gknd 7667 9 C c JJ cord-010119-t1x9gknd 7667 10 reagents reagent NNS cord-010119-t1x9gknd 7667 11 , , , cord-010119-t1x9gknd 7667 12 with with IN cord-010119-t1x9gknd 7667 13 a a DT cord-010119-t1x9gknd 7667 14 similar similar JJ cord-010119-t1x9gknd 7667 15 pattern pattern NN cord-010119-t1x9gknd 7667 16 of of IN cord-010119-t1x9gknd 7667 17 reactivity reactivity NN cord-010119-t1x9gknd 7667 18 : : : cord-010119-t1x9gknd 7667 19 3 3 CD cord-010119-t1x9gknd 7667 20 - - SYM cord-010119-t1x9gknd 7667 21 41 41 CD cord-010119-t1x9gknd 7667 22 with with IN cord-010119-t1x9gknd 7667 23 MS24 MS24 NNP cord-010119-t1x9gknd 7667 24 ( ( -LRB- cord-010119-t1x9gknd 7667 25 n515 n515 NNS cord-010119-t1x9gknd 7667 26 ) ) -RRB- cord-010119-t1x9gknd 7667 27 , , , cord-010119-t1x9gknd 7667 28 1 1 CD cord-010119-t1x9gknd 7667 29 - - SYM cord-010119-t1x9gknd 7667 30 31 31 CD cord-010119-t1x9gknd 7667 31 S S NNP cord-010119-t1x9gknd 7667 32 with with IN cord-010119-t1x9gknd 7667 33 MS23 MS23 NNP cord-010119-t1x9gknd 7667 34 ( ( -LRB- cord-010119-t1x9gknd 7667 35 n59 n59 NN cord-010119-t1x9gknd 7667 36 ) ) -RRB- cord-010119-t1x9gknd 7667 37 , , , cord-010119-t1x9gknd 7667 38 no no DT cord-010119-t1x9gknd 7667 39 reaction reaction NN cord-010119-t1x9gknd 7667 40 with with IN cord-010119-t1x9gknd 7667 41 MS273 MS273 NNP cord-010119-t1x9gknd 7667 42 , , , cord-010119-t1x9gknd 7667 43 DGC02 DGC02 NNP cord-010119-t1x9gknd 7667 44 , , , cord-010119-t1x9gknd 7667 45 P3x255 P3x255 NNP cord-010119-t1x9gknd 7667 46 ( ( -LRB- cord-010119-t1x9gknd 7667 47 n514 n514 NNP cord-010119-t1x9gknd 7667 48 ) ) -RRB- cord-010119-t1x9gknd 7667 49 . . . cord-010119-t1x9gknd 7668 1 14 14 CD cord-010119-t1x9gknd 7668 2 samples sample NNS cord-010119-t1x9gknd 7668 3 tested test VBN cord-010119-t1x9gknd 7668 4 with with IN cord-010119-t1x9gknd 7668 5 a a DT cord-010119-t1x9gknd 7668 6 polyclonal polyclonal JJ cord-010119-t1x9gknd 7668 7 anti anti NN cord-010119-t1x9gknd 7668 8 - - NNP cord-010119-t1x9gknd 7668 9 C C NNP cord-010119-t1x9gknd 7668 10 showed show VBD cord-010119-t1x9gknd 7668 11 a a DT cord-010119-t1x9gknd 7668 12 1 1 CD cord-010119-t1x9gknd 7668 13 - - SYM cord-010119-t1x9gknd 7668 14 31 31 CD cord-010119-t1x9gknd 7668 15 reactivity reactivity NN cord-010119-t1x9gknd 7668 16 . . . cord-010119-t1x9gknd 7669 1 3 3 CD cord-010119-t1x9gknd 7669 2 D1C1E1c1e1 D1C1E1c1e1 NNP cord-010119-t1x9gknd 7669 3 cases case NNS cord-010119-t1x9gknd 7669 4 tested test VBN cord-010119-t1x9gknd 7669 5 with with IN cord-010119-t1x9gknd 7669 6 a a DT cord-010119-t1x9gknd 7669 7 polyclonal polyclonal JJ cord-010119-t1x9gknd 7669 8 and and CC cord-010119-t1x9gknd 7669 9 monoclonal monoclonal JJ cord-010119-t1x9gknd 7669 10 anti anti NN cord-010119-t1x9gknd 7669 11 - - NN cord-010119-t1x9gknd 7669 12 e e JJ cord-010119-t1x9gknd 7669 13 ( ( -LRB- cord-010119-t1x9gknd 7669 14 MS16 MS16 NNP cord-010119-t1x9gknd 7669 15 , , , cord-010119-t1x9gknd 7669 16 MS21 MS21 NNP cord-010119-t1x9gknd 7669 17 , , , cord-010119-t1x9gknd 7669 18 MS62 MS62 NNP cord-010119-t1x9gknd 7669 19 , , , cord-010119-t1x9gknd 7669 20 MS63 MS63 NNP cord-010119-t1x9gknd 7669 21 ) ) -RRB- cord-010119-t1x9gknd 7669 22 showed show VBD cord-010119-t1x9gknd 7669 23 no no DT cord-010119-t1x9gknd 7669 24 weakened weakened JJ cord-010119-t1x9gknd 7669 25 reactivity reactivity NN cord-010119-t1x9gknd 7669 26 . . . cord-010119-t1x9gknd 7670 1 RHCE RHCE NNP cord-010119-t1x9gknd 7670 2 sequencing sequencing NN cord-010119-t1x9gknd 7670 3 ( ( -LRB- cord-010119-t1x9gknd 7670 4 genomic genomic JJ cord-010119-t1x9gknd 7670 5 DNA dna NN cord-010119-t1x9gknd 7670 6 or or CC cord-010119-t1x9gknd 7670 7 cDNA cdna NN cord-010119-t1x9gknd 7670 8 ) ) -RRB- cord-010119-t1x9gknd 7670 9 showed show VBD cord-010119-t1x9gknd 7670 10 a a DT cord-010119-t1x9gknd 7670 11 c.286 c.286 NNP cord-010119-t1x9gknd 7670 12 G g NN cord-010119-t1x9gknd 7671 1 > > XX cord-010119-t1x9gknd 7672 1 A a DT cord-010119-t1x9gknd 7672 2 mutation mutation NN cord-010119-t1x9gknd 7672 3 in in IN cord-010119-t1x9gknd 7672 4 exon exon NN cord-010119-t1x9gknd 7672 5 2 2 CD cord-010119-t1x9gknd 7672 6 , , , cord-010119-t1x9gknd 7672 7 predicted predict VBN cord-010119-t1x9gknd 7672 8 to to TO cord-010119-t1x9gknd 7672 9 encode encode VB cord-010119-t1x9gknd 7672 10 the the DT cord-010119-t1x9gknd 7672 11 p. p. NN cord-010119-t1x9gknd 7673 1 Gly96Ser Gly96Ser NNP cord-010119-t1x9gknd 7673 2 substitution substitution NN cord-010119-t1x9gknd 7673 3 . . . cord-010119-t1x9gknd 7674 1 For for IN cord-010119-t1x9gknd 7674 2 2 2 CD cord-010119-t1x9gknd 7674 3 apparent apparent JJ cord-010119-t1x9gknd 7674 4 R r NN cord-010119-t1x9gknd 7674 5 1 1 CD cord-010119-t1x9gknd 7674 6 R r NN cord-010119-t1x9gknd 7674 7 2 2 CD cord-010119-t1x9gknd 7674 8 donors donor NNS cord-010119-t1x9gknd 7674 9 , , , cord-010119-t1x9gknd 7674 10 a a DT cord-010119-t1x9gknd 7674 11 f f JJ cord-010119-t1x9gknd 7674 12 - - HYPH cord-010119-t1x9gknd 7674 13 negative negative JJ cord-010119-t1x9gknd 7674 14 type type NN cord-010119-t1x9gknd 7674 15 allowed allow VBD cord-010119-t1x9gknd 7674 16 the the DT cord-010119-t1x9gknd 7674 17 prediction prediction NN cord-010119-t1x9gknd 7674 18 of of IN cord-010119-t1x9gknd 7674 19 a a DT cord-010119-t1x9gknd 7674 20 RHCE*Ce286A RHCE*Ce286A NNS cord-010119-t1x9gknd 7674 21 / / SYM cord-010119-t1x9gknd 7674 22 RHCE*cE rhce*ce NN cord-010119-t1x9gknd 7674 23 genotype genotype NN cord-010119-t1x9gknd 7674 24 . . . cord-010119-t1x9gknd 7675 1 Altogether altogether RB cord-010119-t1x9gknd 7675 2 , , , cord-010119-t1x9gknd 7675 3 our -PRON- PRP$ cord-010119-t1x9gknd 7675 4 results result NNS cord-010119-t1x9gknd 7675 5 are be VBP cord-010119-t1x9gknd 7675 6 consistent consistent JJ cord-010119-t1x9gknd 7675 7 with with IN cord-010119-t1x9gknd 7675 8 the the DT cord-010119-t1x9gknd 7675 9 presence presence NN cord-010119-t1x9gknd 7675 10 of of IN cord-010119-t1x9gknd 7675 11 a a DT cord-010119-t1x9gknd 7675 12 very very RB cord-010119-t1x9gknd 7675 13 likely likely JJ cord-010119-t1x9gknd 7675 14 RHCE*Ce286A RHCE*Ce286A NNS cord-010119-t1x9gknd 7675 15 allele allele NN cord-010119-t1x9gknd 7675 16 ( ( -LRB- cord-010119-t1x9gknd 7675 17 C c NN cord-010119-t1x9gknd 7675 18 and and CC cord-010119-t1x9gknd 7675 19 e e NNP cord-010119-t1x9gknd 7675 20 in in IN cord-010119-t1x9gknd 7675 21 cis cis NNP cord-010119-t1x9gknd 7675 22 ) ) -RRB- cord-010119-t1x9gknd 7675 23 in in IN cord-010119-t1x9gknd 7675 24 all all DT cord-010119-t1x9gknd 7675 25 samples sample NNS cord-010119-t1x9gknd 7675 26 . . . cord-010119-t1x9gknd 7676 1 3 3 CD cord-010119-t1x9gknd 7676 2 D1C1E1c1e1 D1C1E1c1e1 NNP cord-010119-t1x9gknd 7676 3 individuals individual NNS cord-010119-t1x9gknd 7676 4 were be VBD cord-010119-t1x9gknd 7676 5 reactive reactive JJ cord-010119-t1x9gknd 7676 6 11 11 CD cord-010119-t1x9gknd 7676 7 S S NNS cord-010119-t1x9gknd 7676 8 with with IN cord-010119-t1x9gknd 7676 9 the the DT cord-010119-t1x9gknd 7676 10 original original JJ cord-010119-t1x9gknd 7676 11 source source NN cord-010119-t1x9gknd 7676 12 of of IN cord-010119-t1x9gknd 7676 13 anti anti JJ cord-010119-t1x9gknd 7676 14 - - JJ cord-010119-t1x9gknd 7676 15 Rh55 rh55 JJ cord-010119-t1x9gknd 7676 16 , , , cord-010119-t1x9gknd 7676 17 slightly slightly RB cord-010119-t1x9gknd 7676 18 weaker weak JJR cord-010119-t1x9gknd 7676 19 when when WRB cord-010119-t1x9gknd 7676 20 compared compare VBN cord-010119-t1x9gknd 7676 21 to to IN cord-010119-t1x9gknd 7676 22 RHCE*ce286A/ RHCE*ce286A/ NNS cord-010119-t1x9gknd 7677 1 RHCE*Ce RHCE*Ce NNP cord-010119-t1x9gknd 7677 2 RBC RBC NNP cord-010119-t1x9gknd 7677 3 samples sample NNS cord-010119-t1x9gknd 7677 4 available available JJ cord-010119-t1x9gknd 7677 5 from from IN cord-010119-t1x9gknd 7677 6 our -PRON- PRP$ cord-010119-t1x9gknd 7677 7 cryobank cryobank NN cord-010119-t1x9gknd 7677 8 ( ( -LRB- cord-010119-t1x9gknd 7677 9 21 21 CD cord-010119-t1x9gknd 7677 10 ) ) -RRB- cord-010119-t1x9gknd 7677 11 . . . cord-010119-t1x9gknd 7678 1 Conclusion conclusion NN cord-010119-t1x9gknd 7678 2 : : : cord-010119-t1x9gknd 7679 1 Our -PRON- PRP$ cord-010119-t1x9gknd 7679 2 results result NNS cord-010119-t1x9gknd 7679 3 confirm confirm VBP cord-010119-t1x9gknd 7679 4 that that IN cord-010119-t1x9gknd 7679 5 the the DT cord-010119-t1x9gknd 7679 6 c.286 c.286 NNP cord-010119-t1x9gknd 7679 7 G G NNP cord-010119-t1x9gknd 7680 1 > > XX cord-010119-t1x9gknd 7681 1 A a DT cord-010119-t1x9gknd 7681 2 mutation mutation NN cord-010119-t1x9gknd 7681 3 alters alter VBZ cord-010119-t1x9gknd 7681 4 the the DT cord-010119-t1x9gknd 7681 5 conformational conformational JJ cord-010119-t1x9gknd 7681 6 properties property NNS cord-010119-t1x9gknd 7681 7 of of IN cord-010119-t1x9gknd 7681 8 the the DT cord-010119-t1x9gknd 7681 9 RHCE RHCE NNP cord-010119-t1x9gknd 7681 10 protein protein NN cord-010119-t1x9gknd 7681 11 , , , cord-010119-t1x9gknd 7681 12 either either CC cord-010119-t1x9gknd 7681 13 on on IN cord-010119-t1x9gknd 7681 14 a a DT cord-010119-t1x9gknd 7681 15 ce ce NN cord-010119-t1x9gknd 7681 16 or or CC cord-010119-t1x9gknd 7681 17 Ce Ce NNP cord-010119-t1x9gknd 7681 18 background background NN cord-010119-t1x9gknd 7681 19 , , , cord-010119-t1x9gknd 7681 20 and and CC cord-010119-t1x9gknd 7681 21 encodes encode VBZ cord-010119-t1x9gknd 7681 22 the the DT cord-010119-t1x9gknd 7681 23 low low JJ cord-010119-t1x9gknd 7681 24 - - HYPH cord-010119-t1x9gknd 7681 25 prevalence prevalence NN cord-010119-t1x9gknd 7681 26 LOCR LOCR NNP cord-010119-t1x9gknd 7681 27 antigen antigen NN cord-010119-t1x9gknd 7681 28 ( ( -LRB- cord-010119-t1x9gknd 7681 29 RH55 RH55 NNP cord-010119-t1x9gknd 7681 30 ) ) -RRB- cord-010119-t1x9gknd 7681 31 . . . cord-010119-t1x9gknd 7682 1 The the DT cord-010119-t1x9gknd 7682 2 LOCR LOCR NNP cord-010119-t1x9gknd 7682 3 reactivity reactivity NN cord-010119-t1x9gknd 7682 4 appears appear VBZ cord-010119-t1x9gknd 7682 5 to to TO cord-010119-t1x9gknd 7682 6 be be VB cord-010119-t1x9gknd 7682 7 rather rather RB cord-010119-t1x9gknd 7682 8 similar similar JJ cord-010119-t1x9gknd 7682 9 when when WRB cord-010119-t1x9gknd 7682 10 coded code VBN cord-010119-t1x9gknd 7682 11 by by IN cord-010119-t1x9gknd 7682 12 RHCE*Ce286A RHCE*Ce286A NNS cord-010119-t1x9gknd 7682 13 or or CC cord-010119-t1x9gknd 7682 14 RHCE*ce286A RHCE*ce286A NNS cord-010119-t1x9gknd 7682 15 alleles allele NNS cord-010119-t1x9gknd 7682 16 . . . cord-010119-t1x9gknd 7683 1 This this DT cord-010119-t1x9gknd 7683 2 was be VBD cord-010119-t1x9gknd 7683 3 quite quite PDT cord-010119-t1x9gknd 7683 4 an an DT cord-010119-t1x9gknd 7683 5 unexpected unexpected JJ cord-010119-t1x9gknd 7683 6 finding finding NN cord-010119-t1x9gknd 7683 7 , , , cord-010119-t1x9gknd 7683 8 since since IN cord-010119-t1x9gknd 7683 9 the the DT cord-010119-t1x9gknd 7683 10 p. p. NN cord-010119-t1x9gknd 7684 1 Gly96Ser Gly96Ser NNP cord-010119-t1x9gknd 7684 2 substitution substitution NN cord-010119-t1x9gknd 7684 3 is be VBZ cord-010119-t1x9gknd 7684 4 close close JJ cord-010119-t1x9gknd 7684 5 to to IN cord-010119-t1x9gknd 7684 6 the the DT cord-010119-t1x9gknd 7684 7 critical critical JJ cord-010119-t1x9gknd 7684 8 amino amino NN cord-010119-t1x9gknd 7684 9 - - HYPH cord-010119-t1x9gknd 7684 10 acid acid NN cord-010119-t1x9gknd 7684 11 for for IN cord-010119-t1x9gknd 7684 12 C c NN cord-010119-t1x9gknd 7684 13 / / SYM cord-010119-t1x9gknd 7684 14 c c NN cord-010119-t1x9gknd 7684 15 expression expression NN cord-010119-t1x9gknd 7684 16 ( ( -LRB- cord-010119-t1x9gknd 7684 17 p. p. NN cord-010119-t1x9gknd 7685 1 Pro103Ser Pro103Ser NNP cord-010119-t1x9gknd 7685 2 ) ) -RRB- cord-010119-t1x9gknd 7685 3 . . . cord-010119-t1x9gknd 7686 1 None none NN cord-010119-t1x9gknd 7686 2 of of IN cord-010119-t1x9gknd 7686 3 our -PRON- PRP$ cord-010119-t1x9gknd 7686 4 15 15 CD cord-010119-t1x9gknd 7686 5 cases case NNS cord-010119-t1x9gknd 7686 6 made make VBD cord-010119-t1x9gknd 7686 7 anti anti JJ cord-010119-t1x9gknd 7686 8 - - NN cord-010119-t1x9gknd 7686 9 C c JJ cord-010119-t1x9gknd 7686 10 and/or and/or CC cord-010119-t1x9gknd 7686 11 anti anti NNS cord-010119-t1x9gknd 7686 12 - - NN cord-010119-t1x9gknd 7686 13 e e JJ cord-010119-t1x9gknd 7686 14 but but CC cord-010119-t1x9gknd 7686 15 few few JJ cord-010119-t1x9gknd 7686 16 were be VBD cord-010119-t1x9gknd 7686 17 subject subject JJ cord-010119-t1x9gknd 7686 18 to to IN cord-010119-t1x9gknd 7686 19 a a DT cord-010119-t1x9gknd 7686 20 potential potential JJ cord-010119-t1x9gknd 7686 21 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7686 22 background background NN cord-010119-t1x9gknd 7686 23 . . . cord-010119-t1x9gknd 7687 1 However however RB cord-010119-t1x9gknd 7687 2 , , , cord-010119-t1x9gknd 7687 3 as as IN cord-010119-t1x9gknd 7687 4 RHCE*-ce286A RHCE*-ce286A NNS cord-010119-t1x9gknd 7687 5 was be VBD cord-010119-t1x9gknd 7687 6 reported report VBN cord-010119-t1x9gknd 7687 7 to to TO cord-010119-t1x9gknd 7687 8 code code VB cord-010119-t1x9gknd 7687 9 for for IN cord-010119-t1x9gknd 7687 10 a a DT cord-010119-t1x9gknd 7687 11 partial partial JJ cord-010119-t1x9gknd 7687 12 c c NN cord-010119-t1x9gknd 7687 13 ( ( -LRB- cord-010119-t1x9gknd 7687 14 Rh:-26 Rh:-26 NNP cord-010119-t1x9gknd 7687 15 ) ) -RRB- cord-010119-t1x9gknd 7687 16 , , , cord-010119-t1x9gknd 7687 17 we -PRON- PRP cord-010119-t1x9gknd 7687 18 consider consider VBP cord-010119-t1x9gknd 7687 19 that that IN cord-010119-t1x9gknd 7687 20 RHCE*Ce286A RHCE*Ce286A VBZ cord-010119-t1x9gknd 7687 21 likely likely RB cord-010119-t1x9gknd 7687 22 encodes encode VBZ cord-010119-t1x9gknd 7687 23 partial partial JJ cord-010119-t1x9gknd 7687 24 C c NN cord-010119-t1x9gknd 7687 25 and and CC cord-010119-t1x9gknd 7687 26 e e NNP cord-010119-t1x9gknd 7687 27 , , , cord-010119-t1x9gknd 7687 28 this this DT cord-010119-t1x9gknd 7687 29 being be VBG cord-010119-t1x9gknd 7687 30 also also RB cord-010119-t1x9gknd 7687 31 supported support VBN cord-010119-t1x9gknd 7687 32 by by IN cord-010119-t1x9gknd 7687 33 the the DT cord-010119-t1x9gknd 7687 34 predicted predict VBN cord-010119-t1x9gknd 7687 35 localization localization NN cord-010119-t1x9gknd 7687 36 of of IN cord-010119-t1x9gknd 7687 37 the the DT cord-010119-t1x9gknd 7687 38 p. p. NN cord-010119-t1x9gknd 7688 1 Gly96Ser Gly96Ser NNP cord-010119-t1x9gknd 7688 2 change change VBP cord-010119-t1x9gknd 7688 3 on on IN cord-010119-t1x9gknd 7688 4 the the DT cord-010119-t1x9gknd 7688 5 second second JJ cord-010119-t1x9gknd 7688 6 extracellular extracellular JJ cord-010119-t1x9gknd 7688 7 loop loop NN cord-010119-t1x9gknd 7688 8 of of IN cord-010119-t1x9gknd 7688 9 the the DT cord-010119-t1x9gknd 7688 10 RhCe RhCe NNP cord-010119-t1x9gknd 7688 11 protein protein NN cord-010119-t1x9gknd 7688 12 . . . cord-010119-t1x9gknd 7689 1 Background Background NNP cord-010119-t1x9gknd 7689 2 / / SYM cord-010119-t1x9gknd 7689 3 Case Case NNP cord-010119-t1x9gknd 7689 4 Studies Studies NNPS cord-010119-t1x9gknd 7690 1 : : : cord-010119-t1x9gknd 7690 2 Weak weak JJ cord-010119-t1x9gknd 7690 3 D d NN cord-010119-t1x9gknd 7690 4 genotyping genotyping NN cord-010119-t1x9gknd 7690 5 is be VBZ cord-010119-t1x9gknd 7690 6 recommended recommend VBN cord-010119-t1x9gknd 7690 7 for for IN cord-010119-t1x9gknd 7690 8 transfusion transfusion NN cord-010119-t1x9gknd 7690 9 recipients recipient NNS cord-010119-t1x9gknd 7690 10 , , , cord-010119-t1x9gknd 7690 11 pregnant pregnant JJ cord-010119-t1x9gknd 7690 12 women woman NNS cord-010119-t1x9gknd 7690 13 , , , cord-010119-t1x9gknd 7690 14 and and CC cord-010119-t1x9gknd 7690 15 newborns newborn NNS cord-010119-t1x9gknd 7690 16 who who WP cord-010119-t1x9gknd 7690 17 had have VBD cord-010119-t1x9gknd 7690 18 a a DT cord-010119-t1x9gknd 7690 19 RhD rhd NN cord-010119-t1x9gknd 7690 20 typing typing NN cord-010119-t1x9gknd 7690 21 discrepancy discrepancy NN cord-010119-t1x9gknd 7690 22 , , , cord-010119-t1x9gknd 7690 23 or or CC cord-010119-t1x9gknd 7690 24 a a DT cord-010119-t1x9gknd 7690 25 serological serological JJ cord-010119-t1x9gknd 7690 26 weak weak JJ cord-010119-t1x9gknd 7690 27 D d NN cord-010119-t1x9gknd 7690 28 phenotype phenotype NN cord-010119-t1x9gknd 7690 29 , , , cord-010119-t1x9gknd 7690 30 to to TO cord-010119-t1x9gknd 7690 31 determine determine VB cord-010119-t1x9gknd 7690 32 if if IN cord-010119-t1x9gknd 7690 33 they -PRON- PRP cord-010119-t1x9gknd 7690 34 carried carry VBD cord-010119-t1x9gknd 7690 35 the the DT cord-010119-t1x9gknd 7690 36 weak weak JJ cord-010119-t1x9gknd 7690 37 D d NN cord-010119-t1x9gknd 7690 38 genotypes genotype NNS cord-010119-t1x9gknd 7690 39 1 1 CD cord-010119-t1x9gknd 7690 40 , , , cord-010119-t1x9gknd 7690 41 2 2 CD cord-010119-t1x9gknd 7690 42 or or CC cord-010119-t1x9gknd 7690 43 3 3 CD cord-010119-t1x9gknd 7690 44 . . . cord-010119-t1x9gknd 7691 1 The the DT cord-010119-t1x9gknd 7691 2 purpose purpose NN cord-010119-t1x9gknd 7691 3 of of IN cord-010119-t1x9gknd 7691 4 this this DT cord-010119-t1x9gknd 7691 5 study study NN cord-010119-t1x9gknd 7691 6 was be VBD cord-010119-t1x9gknd 7691 7 to to TO cord-010119-t1x9gknd 7691 8 analyze analyze VB cord-010119-t1x9gknd 7691 9 the the DT cord-010119-t1x9gknd 7691 10 underlying underlying JJ cord-010119-t1x9gknd 7691 11 RHD RHD NNP cord-010119-t1x9gknd 7691 12 genotypes genotype NNS cord-010119-t1x9gknd 7691 13 of of IN cord-010119-t1x9gknd 7691 14 the the DT cord-010119-t1x9gknd 7691 15 patient patient NN cord-010119-t1x9gknd 7691 16 samples sample NNS cord-010119-t1x9gknd 7691 17 received receive VBN cord-010119-t1x9gknd 7691 18 for for IN cord-010119-t1x9gknd 7691 19 weak weak JJ cord-010119-t1x9gknd 7691 20 D D NNP cord-010119-t1x9gknd 7691 21 genotyping genotyping NN cord-010119-t1x9gknd 7691 22 since since IN cord-010119-t1x9gknd 7691 23 published publish VBN cord-010119-t1x9gknd 7691 24 recommendations recommendation NNS cord-010119-t1x9gknd 7691 25 , , , cord-010119-t1x9gknd 7691 26 in in IN cord-010119-t1x9gknd 7691 27 particular particular JJ cord-010119-t1x9gknd 7691 28 those those DT cord-010119-t1x9gknd 7691 29 found find VBN cord-010119-t1x9gknd 7691 30 to to TO cord-010119-t1x9gknd 7691 31 not not RB cord-010119-t1x9gknd 7691 32 carry carry VB cord-010119-t1x9gknd 7691 33 the the DT cord-010119-t1x9gknd 7691 34 weak weak JJ cord-010119-t1x9gknd 7691 35 D D NNP cord-010119-t1x9gknd 7691 36 1 1 CD cord-010119-t1x9gknd 7691 37 , , , cord-010119-t1x9gknd 7691 38 2 2 CD cord-010119-t1x9gknd 7691 39 , , , cord-010119-t1x9gknd 7691 40 or or CC cord-010119-t1x9gknd 7691 41 3 3 CD cord-010119-t1x9gknd 7691 42 genotypes genotype NNS cord-010119-t1x9gknd 7691 43 . . . cord-010119-t1x9gknd 7692 1 Study Study NNP cord-010119-t1x9gknd 7692 2 Design Design NNP cord-010119-t1x9gknd 7692 3 / / SYM cord-010119-t1x9gknd 7692 4 Methods method NNS cord-010119-t1x9gknd 7692 5 : : : cord-010119-t1x9gknd 7693 1 Between between IN cord-010119-t1x9gknd 7693 2 9/2015 9/2015 CD cord-010119-t1x9gknd 7693 3 and and CC cord-010119-t1x9gknd 7693 4 2/2017 2/2017 CD cord-010119-t1x9gknd 7693 5 50 50 CD cord-010119-t1x9gknd 7693 6 samples sample NNS cord-010119-t1x9gknd 7693 7 were be VBD cord-010119-t1x9gknd 7693 8 received receive VBN cord-010119-t1x9gknd 7693 9 for for IN cord-010119-t1x9gknd 7693 10 weak weak JJ cord-010119-t1x9gknd 7693 11 D d NN cord-010119-t1x9gknd 7693 12 genotyping genotyping NN cord-010119-t1x9gknd 7693 13 . . . cord-010119-t1x9gknd 7694 1 Testing testing NN cord-010119-t1x9gknd 7694 2 was be VBD cord-010119-t1x9gknd 7694 3 performed perform VBN cord-010119-t1x9gknd 7694 4 using use VBG cord-010119-t1x9gknd 7694 5 PCR PCR NNP cord-010119-t1x9gknd 7694 6 - - HYPH cord-010119-t1x9gknd 7694 7 RFLP RFLP NNP cord-010119-t1x9gknd 7694 8 targeting target VBG cord-010119-t1x9gknd 7694 9 the the DT cord-010119-t1x9gknd 7694 10 sequence sequence NN cord-010119-t1x9gknd 7694 11 variants variant NNS cord-010119-t1x9gknd 7694 12 in in IN cord-010119-t1x9gknd 7694 13 the the DT cord-010119-t1x9gknd 7694 14 RHD RHD NNP cord-010119-t1x9gknd 7694 15 gene gene NN cord-010119-t1x9gknd 7694 16 that that WDT cord-010119-t1x9gknd 7694 17 have have VBP cord-010119-t1x9gknd 7694 18 been be VBN cord-010119-t1x9gknd 7694 19 previously previously RB cord-010119-t1x9gknd 7694 20 defined define VBN cord-010119-t1x9gknd 7694 21 . . . cord-010119-t1x9gknd 7695 1 Samples sample NNS cord-010119-t1x9gknd 7695 2 that that WDT cord-010119-t1x9gknd 7695 3 did do VBD cord-010119-t1x9gknd 7695 4 not not RB cord-010119-t1x9gknd 7695 5 have have VB cord-010119-t1x9gknd 7695 6 weak weak JJ cord-010119-t1x9gknd 7695 7 D d NN cord-010119-t1x9gknd 7695 8 types type NNS cord-010119-t1x9gknd 7695 9 1 1 CD cord-010119-t1x9gknd 7695 10 , , , cord-010119-t1x9gknd 7695 11 2 2 CD cord-010119-t1x9gknd 7695 12 , , , cord-010119-t1x9gknd 7695 13 or or CC cord-010119-t1x9gknd 7695 14 3 3 CD cord-010119-t1x9gknd 7695 15 genotypes genotype NNS cord-010119-t1x9gknd 7695 16 , , , cord-010119-t1x9gknd 7695 17 but but CC cord-010119-t1x9gknd 7695 18 156A 156a CD cord-010119-t1x9gknd 7695 19 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 7695 20 2017 2017 CD cord-010119-t1x9gknd 7695 21 Vol Vol NNP cord-010119-t1x9gknd 7695 22 . . . cord-010119-t1x9gknd 7696 1 57 57 CD cord-010119-t1x9gknd 7696 2 Supplement Supplement NNP cord-010119-t1x9gknd 7696 3 S3 S3 NNP cord-010119-t1x9gknd 7696 4 had have VBD cord-010119-t1x9gknd 7696 5 evidence evidence NN cord-010119-t1x9gknd 7696 6 of of IN cord-010119-t1x9gknd 7696 7 RHD rhd JJ cord-010119-t1x9gknd 7696 8 genetic genetic JJ cord-010119-t1x9gknd 7696 9 sequences sequence NNS cord-010119-t1x9gknd 7696 10 in in IN cord-010119-t1x9gknd 7696 11 exon exon NN cord-010119-t1x9gknd 7696 12 7 7 CD cord-010119-t1x9gknd 7696 13 and/or and/or CC cord-010119-t1x9gknd 7696 14 intron intron NN cord-010119-t1x9gknd 7696 15 4 4 CD cord-010119-t1x9gknd 7696 16 in in IN cord-010119-t1x9gknd 7696 17 preliminary preliminary JJ cord-010119-t1x9gknd 7696 18 testing testing NN cord-010119-t1x9gknd 7696 19 were be VBD cord-010119-t1x9gknd 7696 20 evaluated evaluate VBN cord-010119-t1x9gknd 7696 21 by by IN cord-010119-t1x9gknd 7696 22 Sanger Sanger NNP cord-010119-t1x9gknd 7696 23 sequencing sequencing NN cord-010119-t1x9gknd 7696 24 for for IN cord-010119-t1x9gknd 7696 25 RHD RHD NNP cord-010119-t1x9gknd 7696 26 and and CC cord-010119-t1x9gknd 7696 27 RHCE RHCE NNP cord-010119-t1x9gknd 7696 28 exons exon NNS cord-010119-t1x9gknd 7696 29 1 1 CD cord-010119-t1x9gknd 7696 30 - - SYM cord-010119-t1x9gknd 7696 31 10 10 CD cord-010119-t1x9gknd 7696 32 to to TO cord-010119-t1x9gknd 7696 33 determine determine VB cord-010119-t1x9gknd 7696 34 the the DT cord-010119-t1x9gknd 7696 35 underlying underlying JJ cord-010119-t1x9gknd 7696 36 RH RH NNP cord-010119-t1x9gknd 7696 37 genotype genotype NN cord-010119-t1x9gknd 7696 38 . . . cord-010119-t1x9gknd 7697 1 When when WRB cord-010119-t1x9gknd 7697 2 provided provide VBN cord-010119-t1x9gknd 7697 3 , , , cord-010119-t1x9gknd 7697 4 the the DT cord-010119-t1x9gknd 7697 5 patient patient NN cord-010119-t1x9gknd 7697 6 's 's POS cord-010119-t1x9gknd 7697 7 ethnicity ethnicity NN cord-010119-t1x9gknd 7697 8 and and CC cord-010119-t1x9gknd 7697 9 presence presence NN cord-010119-t1x9gknd 7697 10 of of IN cord-010119-t1x9gknd 7697 11 anti anti JJ cord-010119-t1x9gknd 7697 12 - - NNP cord-010119-t1x9gknd 7697 13 D D NNP cord-010119-t1x9gknd 7697 14 was be VBD cord-010119-t1x9gknd 7697 15 recorded record VBN cord-010119-t1x9gknd 7697 16 . . . cord-010119-t1x9gknd 7698 1 Results result NNS cord-010119-t1x9gknd 7698 2 / / SYM cord-010119-t1x9gknd 7698 3 Findings finding NNS cord-010119-t1x9gknd 7698 4 : : : cord-010119-t1x9gknd 7699 1 The the DT cord-010119-t1x9gknd 7699 2 majority majority NN cord-010119-t1x9gknd 7699 3 of of IN cord-010119-t1x9gknd 7699 4 the the DT cord-010119-t1x9gknd 7699 5 samples sample NNS cord-010119-t1x9gknd 7699 6 were be VBD cord-010119-t1x9gknd 7699 7 from from IN cord-010119-t1x9gknd 7699 8 obstetrical obstetrical JJ cord-010119-t1x9gknd 7699 9 patients patient NNS cord-010119-t1x9gknd 7699 10 ( ( -LRB- cord-010119-t1x9gknd 7699 11 62 62 CD cord-010119-t1x9gknd 7699 12 % % NN cord-010119-t1x9gknd 7699 13 ) ) -RRB- cord-010119-t1x9gknd 7699 14 followed follow VBN cord-010119-t1x9gknd 7699 15 by by IN cord-010119-t1x9gknd 7699 16 transfusion transfusion NN cord-010119-t1x9gknd 7699 17 patients patient NNS cord-010119-t1x9gknd 7699 18 ( ( -LRB- cord-010119-t1x9gknd 7699 19 28 28 CD cord-010119-t1x9gknd 7699 20 % % NN cord-010119-t1x9gknd 7699 21 ) ) -RRB- cord-010119-t1x9gknd 7699 22 ; ; : cord-010119-t1x9gknd 7699 23 10 10 CD cord-010119-t1x9gknd 7699 24 % % NN cord-010119-t1x9gknd 7699 25 had have VBD cord-010119-t1x9gknd 7699 26 no no DT cord-010119-t1x9gknd 7699 27 clinical clinical JJ cord-010119-t1x9gknd 7699 28 indication indication NN cord-010119-t1x9gknd 7699 29 provided provide VBN cord-010119-t1x9gknd 7699 30 . . . cord-010119-t1x9gknd 7700 1 34 34 CD cord-010119-t1x9gknd 7700 2 samples sample NNS cord-010119-t1x9gknd 7700 3 ( ( -LRB- cord-010119-t1x9gknd 7700 4 68 68 CD cord-010119-t1x9gknd 7700 5 % % NN cord-010119-t1x9gknd 7700 6 ) ) -RRB- cord-010119-t1x9gknd 7700 7 were be VBD cord-010119-t1x9gknd 7700 8 found find VBN cord-010119-t1x9gknd 7700 9 to to TO cord-010119-t1x9gknd 7700 10 be be VB cord-010119-t1x9gknd 7700 11 weak weak JJ cord-010119-t1x9gknd 7700 12 D d NN cord-010119-t1x9gknd 7700 13 type type NN cord-010119-t1x9gknd 7700 14 1 1 CD cord-010119-t1x9gknd 7700 15 , , , cord-010119-t1x9gknd 7700 16 2 2 CD cord-010119-t1x9gknd 7700 17 , , , cord-010119-t1x9gknd 7700 18 or or CC cord-010119-t1x9gknd 7700 19 3 3 CD cord-010119-t1x9gknd 7700 20 ( ( -LRB- cord-010119-t1x9gknd 7700 21 24 24 CD cord-010119-t1x9gknd 7700 22 , , , cord-010119-t1x9gknd 7700 23 6 6 CD cord-010119-t1x9gknd 7700 24 , , , cord-010119-t1x9gknd 7700 25 and and CC cord-010119-t1x9gknd 7700 26 4 4 CD cord-010119-t1x9gknd 7700 27 samples sample NNS cord-010119-t1x9gknd 7700 28 , , , cord-010119-t1x9gknd 7700 29 respectively respectively RB cord-010119-t1x9gknd 7700 30 ) ) -RRB- cord-010119-t1x9gknd 7700 31 . . . cord-010119-t1x9gknd 7701 1 5 5 CD cord-010119-t1x9gknd 7701 2 samples sample NNS cord-010119-t1x9gknd 7701 3 ( ( -LRB- cord-010119-t1x9gknd 7701 4 10 10 CD cord-010119-t1x9gknd 7701 5 % % NN cord-010119-t1x9gknd 7701 6 ) ) -RRB- cord-010119-t1x9gknd 7701 7 appear appear VBP cord-010119-t1x9gknd 7701 8 to to TO cord-010119-t1x9gknd 7701 9 be be VB cord-010119-t1x9gknd 7701 10 genetically genetically RB cord-010119-t1x9gknd 7701 11 RHD RHD NNP cord-010119-t1x9gknd 7701 12 negative negative JJ cord-010119-t1x9gknd 7701 13 . . . cord-010119-t1x9gknd 7702 1 Genetic genetic JJ cord-010119-t1x9gknd 7702 2 sequencing sequencing NN cord-010119-t1x9gknd 7702 3 was be VBD cord-010119-t1x9gknd 7702 4 performed perform VBN cord-010119-t1x9gknd 7702 5 on on IN cord-010119-t1x9gknd 7702 6 11 11 CD cord-010119-t1x9gknd 7702 7 samples sample NNS cord-010119-t1x9gknd 7702 8 ; ; : cord-010119-t1x9gknd 7702 9 9 9 CD cord-010119-t1x9gknd 7702 10 had have VBD cord-010119-t1x9gknd 7702 11 RHD rhd JJ cord-010119-t1x9gknd 7702 12 genetic genetic JJ cord-010119-t1x9gknd 7702 13 variants variant NNS cord-010119-t1x9gknd 7702 14 that that WDT cord-010119-t1x9gknd 7702 15 were be VBD cord-010119-t1x9gknd 7702 16 not not RB cord-010119-t1x9gknd 7702 17 weak weak JJ cord-010119-t1x9gknd 7702 18 D d NN cord-010119-t1x9gknd 7702 19 types type NNS cord-010119-t1x9gknd 7702 20 1 1 CD cord-010119-t1x9gknd 7702 21 , , , cord-010119-t1x9gknd 7702 22 2 2 CD cord-010119-t1x9gknd 7702 23 , , , cord-010119-t1x9gknd 7702 24 or or CC cord-010119-t1x9gknd 7702 25 3 3 LS cord-010119-t1x9gknd 7702 26 ( ( -LRB- cord-010119-t1x9gknd 7702 27 Table table NN cord-010119-t1x9gknd 7702 28 ) ) -RRB- cord-010119-t1x9gknd 7702 29 . . . cord-010119-t1x9gknd 7703 1 All all DT cord-010119-t1x9gknd 7703 2 of of IN cord-010119-t1x9gknd 7703 3 these these DT cord-010119-t1x9gknd 7703 4 variant variant JJ cord-010119-t1x9gknd 7703 5 RHD rhd NN cord-010119-t1x9gknd 7703 6 samples sample NNS cord-010119-t1x9gknd 7703 7 also also RB cord-010119-t1x9gknd 7703 8 showed show VBD cord-010119-t1x9gknd 7703 9 some some DT cord-010119-t1x9gknd 7703 10 variation variation NN cord-010119-t1x9gknd 7703 11 in in IN cord-010119-t1x9gknd 7703 12 the the DT cord-010119-t1x9gknd 7703 13 RHCE RHCE NNP cord-010119-t1x9gknd 7703 14 gene gene NN cord-010119-t1x9gknd 7703 15 . . . cord-010119-t1x9gknd 7704 1 Two two CD cord-010119-t1x9gknd 7704 2 samples sample NNS cord-010119-t1x9gknd 7704 3 ( ( -LRB- cord-010119-t1x9gknd 7704 4 4 4 CD cord-010119-t1x9gknd 7704 5 % % NN cord-010119-t1x9gknd 7704 6 ) ) -RRB- cord-010119-t1x9gknd 7704 7 had have VBD cord-010119-t1x9gknd 7704 8 wild wild JJ cord-010119-t1x9gknd 7704 9 type type NN cord-010119-t1x9gknd 7704 10 RHD rhd NN cord-010119-t1x9gknd 7704 11 alleles allele NNS cord-010119-t1x9gknd 7704 12 ; ; : cord-010119-t1x9gknd 7704 13 further further JJ cord-010119-t1x9gknd 7704 14 evaluation evaluation NN cord-010119-t1x9gknd 7704 15 is be VBZ cord-010119-t1x9gknd 7704 16 ongoing ongoing JJ cord-010119-t1x9gknd 7704 17 . . . cord-010119-t1x9gknd 7705 1 Conclusion conclusion NN cord-010119-t1x9gknd 7705 2 : : : cord-010119-t1x9gknd 7706 1 Most Most JJS cord-010119-t1x9gknd 7706 2 samples sample NNS cord-010119-t1x9gknd 7706 3 tested test VBN cord-010119-t1x9gknd 7706 4 by by IN cord-010119-t1x9gknd 7706 5 weak weak JJ cord-010119-t1x9gknd 7706 6 D d NN cord-010119-t1x9gknd 7706 7 genotyping genotyping NN cord-010119-t1x9gknd 7706 8 were be VBD cord-010119-t1x9gknd 7706 9 found find VBN cord-010119-t1x9gknd 7706 10 to to TO cord-010119-t1x9gknd 7706 11 be be VB cord-010119-t1x9gknd 7706 12 weak weak JJ cord-010119-t1x9gknd 7706 13 D d NN cord-010119-t1x9gknd 7706 14 types type NNS cord-010119-t1x9gknd 7706 15 1 1 CD cord-010119-t1x9gknd 7706 16 - - SYM cord-010119-t1x9gknd 7706 17 3 3 CD cord-010119-t1x9gknd 7706 18 . . . cord-010119-t1x9gknd 7707 1 Of of IN cord-010119-t1x9gknd 7707 2 the the DT cord-010119-t1x9gknd 7707 3 11 11 CD cord-010119-t1x9gknd 7707 4 samples sample NNS cord-010119-t1x9gknd 7707 5 that that WDT cord-010119-t1x9gknd 7707 6 had have VBD cord-010119-t1x9gknd 7707 7 evidence evidence NN cord-010119-t1x9gknd 7707 8 of of IN cord-010119-t1x9gknd 7707 9 an an DT cord-010119-t1x9gknd 7707 10 RHD RHD NNP cord-010119-t1x9gknd 7707 11 gene gene NN cord-010119-t1x9gknd 7707 12 and and CC cord-010119-t1x9gknd 7707 13 did do VBD cord-010119-t1x9gknd 7707 14 not not RB cord-010119-t1x9gknd 7707 15 carry carry VB cord-010119-t1x9gknd 7707 16 the the DT cord-010119-t1x9gknd 7707 17 known know VBN cord-010119-t1x9gknd 7707 18 weak weak JJ cord-010119-t1x9gknd 7707 19 D d NN cord-010119-t1x9gknd 7707 20 types type NNS cord-010119-t1x9gknd 7707 21 1 1 CD cord-010119-t1x9gknd 7707 22 - - SYM cord-010119-t1x9gknd 7707 23 3 3 CD cord-010119-t1x9gknd 7707 24 polymorphisms polymorphism NNS cord-010119-t1x9gknd 7707 25 , , , cord-010119-t1x9gknd 7707 26 9 9 CD cord-010119-t1x9gknd 7707 27 ( ( -LRB- cord-010119-t1x9gknd 7707 28 82 82 CD cord-010119-t1x9gknd 7707 29 % % NN cord-010119-t1x9gknd 7707 30 ) ) -RRB- cord-010119-t1x9gknd 7707 31 of of IN cord-010119-t1x9gknd 7707 32 were be VBD cord-010119-t1x9gknd 7707 33 found find VBN cord-010119-t1x9gknd 7707 34 to to TO cord-010119-t1x9gknd 7707 35 have have VB cord-010119-t1x9gknd 7707 36 other other JJ cord-010119-t1x9gknd 7707 37 RHD RHD NNP cord-010119-t1x9gknd 7707 38 variants variant NNS cord-010119-t1x9gknd 7707 39 , , , cord-010119-t1x9gknd 7707 40 and and CC cord-010119-t1x9gknd 7707 41 2 2 CD cord-010119-t1x9gknd 7707 42 ( ( -LRB- cord-010119-t1x9gknd 7707 43 18 18 CD cord-010119-t1x9gknd 7707 44 % % NN cord-010119-t1x9gknd 7707 45 ) ) -RRB- cord-010119-t1x9gknd 7707 46 did do VBD cord-010119-t1x9gknd 7707 47 not not RB cord-010119-t1x9gknd 7707 48 have have VB cord-010119-t1x9gknd 7707 49 underlying underlying JJ cord-010119-t1x9gknd 7707 50 genetic genetic JJ cord-010119-t1x9gknd 7707 51 variation variation NN cord-010119-t1x9gknd 7707 52 detected detect VBN cord-010119-t1x9gknd 7707 53 in in IN cord-010119-t1x9gknd 7707 54 the the DT cord-010119-t1x9gknd 7707 55 RHD RHD NNP cord-010119-t1x9gknd 7707 56 gene gene NN cord-010119-t1x9gknd 7707 57 . . . cord-010119-t1x9gknd 7708 1 The the DT cord-010119-t1x9gknd 7708 2 majority majority NN cord-010119-t1x9gknd 7708 3 of of IN cord-010119-t1x9gknd 7708 4 the the DT cord-010119-t1x9gknd 7708 5 non non AFX cord-010119-t1x9gknd 7708 6 weak weak JJ cord-010119-t1x9gknd 7708 7 D d NN cord-010119-t1x9gknd 7708 8 types type NNS cord-010119-t1x9gknd 7708 9 1 1 CD cord-010119-t1x9gknd 7708 10 - - SYM cord-010119-t1x9gknd 7708 11 3 3 CD cord-010119-t1x9gknd 7708 12 variants variant NNS cord-010119-t1x9gknd 7708 13 were be VBD cord-010119-t1x9gknd 7708 14 DAR DAR NNP cord-010119-t1x9gknd 7708 15 alleles allele NNS cord-010119-t1x9gknd 7708 16 , , , cord-010119-t1x9gknd 7708 17 which which WDT cord-010119-t1x9gknd 7708 18 are be VBP cord-010119-t1x9gknd 7708 19 often often RB cord-010119-t1x9gknd 7708 20 associated associate VBN cord-010119-t1x9gknd 7708 21 with with IN cord-010119-t1x9gknd 7708 22 anti anti JJ cord-010119-t1x9gknd 7708 23 - - JJ cord-010119-t1x9gknd 7708 24 D d JJ cord-010119-t1x9gknd 7708 25 production production NN cord-010119-t1x9gknd 7708 26 . . . cord-010119-t1x9gknd 7708 27 _SP cord-010119-t1x9gknd 7709 1 Background Background NNP cord-010119-t1x9gknd 7709 2 / / SYM cord-010119-t1x9gknd 7709 3 Case Case NNP cord-010119-t1x9gknd 7709 4 Studies Studies NNPS cord-010119-t1x9gknd 7709 5 : : : cord-010119-t1x9gknd 7709 6 RHD rhd NN cord-010119-t1x9gknd 7709 7 genotyping genotyping NN cord-010119-t1x9gknd 7709 8 has have VBZ cord-010119-t1x9gknd 7709 9 been be VBN cord-010119-t1x9gknd 7709 10 recommended recommend VBN cord-010119-t1x9gknd 7709 11 to to TO cord-010119-t1x9gknd 7709 12 guide guide VB cord-010119-t1x9gknd 7709 13 transfusion transfusion NN cord-010119-t1x9gknd 7709 14 of of IN cord-010119-t1x9gknd 7709 15 D d JJ cord-010119-t1x9gknd 7709 16 - - HYPH cord-010119-t1x9gknd 7709 17 negative negative JJ cord-010119-t1x9gknd 7709 18 RBCs rbc NNS cord-010119-t1x9gknd 7709 19 and and CC cord-010119-t1x9gknd 7709 20 administration administration NN cord-010119-t1x9gknd 7709 21 of of IN cord-010119-t1x9gknd 7709 22 Rh Rh NNP cord-010119-t1x9gknd 7709 23 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 7709 24 to to IN cord-010119-t1x9gknd 7709 25 patients patient NNS cord-010119-t1x9gknd 7709 26 with with IN cord-010119-t1x9gknd 7709 27 discordant discordant JJ cord-010119-t1x9gknd 7709 28 or or CC cord-010119-t1x9gknd 7709 29 weaker weak JJR cord-010119-t1x9gknd 7709 30 than than IN cord-010119-t1x9gknd 7709 31 expected expect VBN cord-010119-t1x9gknd 7709 32 D d NN cord-010119-t1x9gknd 7709 33 typing typing NN cord-010119-t1x9gknd 7709 34 , , , cord-010119-t1x9gknd 7709 35 particularly particularly RB cord-010119-t1x9gknd 7709 36 for for IN cord-010119-t1x9gknd 7709 37 females female NNS cord-010119-t1x9gknd 7709 38 and and CC cord-010119-t1x9gknd 7709 39 OB OB NNP cord-010119-t1x9gknd 7709 40 patients patient NNS cord-010119-t1x9gknd 7709 41 . . . cord-010119-t1x9gknd 7710 1 The the DT cord-010119-t1x9gknd 7710 2 recommendation recommendation NN cord-010119-t1x9gknd 7710 3 is be VBZ cord-010119-t1x9gknd 7710 4 based base VBN cord-010119-t1x9gknd 7710 5 on on IN cord-010119-t1x9gknd 7710 6 observational observational JJ cord-010119-t1x9gknd 7710 7 evidence evidence NN cord-010119-t1x9gknd 7710 8 , , , cord-010119-t1x9gknd 7710 9 primarily primarily RB cord-010119-t1x9gknd 7710 10 from from IN cord-010119-t1x9gknd 7710 11 Europe Europe NNP cord-010119-t1x9gknd 7710 12 ( ( -LRB- cord-010119-t1x9gknd 7710 13 Flegel Flegel NNP cord-010119-t1x9gknd 7710 14 2006 2006 CD cord-010119-t1x9gknd 7710 15 , , , cord-010119-t1x9gknd 7710 16 Curr Curr NNP cord-010119-t1x9gknd 7710 17 Opin Opin NNP cord-010119-t1x9gknd 7710 18 Hematol13:476 Hematol13:476 NNP cord-010119-t1x9gknd 7710 19 ) ) -RRB- cord-010119-t1x9gknd 7710 20 , , , cord-010119-t1x9gknd 7710 21 that that IN cord-010119-t1x9gknd 7710 22 individuals individual NNS cord-010119-t1x9gknd 7710 23 with with IN cord-010119-t1x9gknd 7710 24 weak weak JJ cord-010119-t1x9gknd 7710 25 D d NN cord-010119-t1x9gknd 7710 26 types type NNS cord-010119-t1x9gknd 7710 27 1 1 CD cord-010119-t1x9gknd 7710 28 , , , cord-010119-t1x9gknd 7710 29 2 2 CD cord-010119-t1x9gknd 7710 30 , , , cord-010119-t1x9gknd 7710 31 and and CC cord-010119-t1x9gknd 7710 32 3 3 CD cord-010119-t1x9gknd 7710 33 are be VBP cord-010119-t1x9gknd 7710 34 not not RB cord-010119-t1x9gknd 7710 35 at at IN cord-010119-t1x9gknd 7710 36 risk risk NN cord-010119-t1x9gknd 7710 37 for for IN cord-010119-t1x9gknd 7710 38 clinically clinically RB cord-010119-t1x9gknd 7710 39 significant significant JJ cord-010119-t1x9gknd 7710 40 anti anti JJ cord-010119-t1x9gknd 7710 41 - - JJ cord-010119-t1x9gknd 7710 42 D. D. NNP cord-010119-t1x9gknd 7711 1 The the DT cord-010119-t1x9gknd 7711 2 implications implication NNS cord-010119-t1x9gknd 7711 3 and and CC cord-010119-t1x9gknd 7711 4 utility utility NN cord-010119-t1x9gknd 7711 5 of of IN cord-010119-t1x9gknd 7711 6 this this DT cord-010119-t1x9gknd 7711 7 approach approach NN cord-010119-t1x9gknd 7711 8 for for IN cord-010119-t1x9gknd 7711 9 the the DT cord-010119-t1x9gknd 7711 10 diverse diverse JJ cord-010119-t1x9gknd 7711 11 U.S. U.S. NNP cord-010119-t1x9gknd 7711 12 population population NN cord-010119-t1x9gknd 7711 13 are be VBP cord-010119-t1x9gknd 7711 14 not not RB cord-010119-t1x9gknd 7711 15 yet yet RB cord-010119-t1x9gknd 7711 16 clear clear JJ cord-010119-t1x9gknd 7711 17 . . . cord-010119-t1x9gknd 7712 1 Here here RB cord-010119-t1x9gknd 7712 2 we -PRON- PRP cord-010119-t1x9gknd 7712 3 report report VBP cord-010119-t1x9gknd 7712 4 15 15 CD cord-010119-t1x9gknd 7712 5 months month NNS cord-010119-t1x9gknd 7712 6 experience experience NN cord-010119-t1x9gknd 7712 7 with with IN cord-010119-t1x9gknd 7712 8 RHD RHD NNP cord-010119-t1x9gknd 7712 9 genotyping genotyping NN cord-010119-t1x9gknd 7712 10 on on IN cord-010119-t1x9gknd 7712 11 352 352 CD cord-010119-t1x9gknd 7712 12 samples sample NNS cord-010119-t1x9gknd 7712 13 referred refer VBN cord-010119-t1x9gknd 7712 14 with with IN cord-010119-t1x9gknd 7712 15 discrepant discrepant JJ cord-010119-t1x9gknd 7712 16 or or CC cord-010119-t1x9gknd 7712 17 weak weak JJ cord-010119-t1x9gknd 7712 18 D d NN cord-010119-t1x9gknd 7712 19 typing typing NN cord-010119-t1x9gknd 7712 20 investigated investigate VBN cord-010119-t1x9gknd 7712 21 from from IN cord-010119-t1x9gknd 7712 22 January January NNP cord-010119-t1x9gknd 7712 23 2016 2016 CD cord-010119-t1x9gknd 7712 24 to to IN cord-010119-t1x9gknd 7712 25 April April NNP cord-010119-t1x9gknd 7712 26 2017 2017 CD cord-010119-t1x9gknd 7712 27 . . . cord-010119-t1x9gknd 7713 1 Study Study NNP cord-010119-t1x9gknd 7713 2 Design Design NNP cord-010119-t1x9gknd 7713 3 / / SYM cord-010119-t1x9gknd 7713 4 Method method NN cord-010119-t1x9gknd 7713 5 : : : cord-010119-t1x9gknd 7713 6 Serologic Serologic NNP cord-010119-t1x9gknd 7713 7 testing testing NN cord-010119-t1x9gknd 7713 8 was be VBD cord-010119-t1x9gknd 7713 9 performed perform VBN cord-010119-t1x9gknd 7713 10 by by IN cord-010119-t1x9gknd 7713 11 standard standard JJ cord-010119-t1x9gknd 7713 12 tube tube NN cord-010119-t1x9gknd 7713 13 agglutination agglutination NN cord-010119-t1x9gknd 7713 14 with with IN cord-010119-t1x9gknd 7713 15 licensed licensed JJ cord-010119-t1x9gknd 7713 16 reagents reagent NNS cord-010119-t1x9gknd 7713 17 . . . cord-010119-t1x9gknd 7714 1 DNA DNA NNP cord-010119-t1x9gknd 7714 2 isolated isolate VBN cord-010119-t1x9gknd 7714 3 from from IN cord-010119-t1x9gknd 7714 4 WBCs wbc NNS cord-010119-t1x9gknd 7714 5 was be VBD cord-010119-t1x9gknd 7714 6 used use VBN cord-010119-t1x9gknd 7714 7 in in IN cord-010119-t1x9gknd 7714 8 manual manual JJ cord-010119-t1x9gknd 7714 9 RFLP RFLP NNP cord-010119-t1x9gknd 7714 10 and and CC cord-010119-t1x9gknd 7714 11 RHD RHD NNP cord-010119-t1x9gknd 7714 12 BeadChip BeadChip NNP cord-010119-t1x9gknd 7714 13 assays assay NNS cord-010119-t1x9gknd 7714 14 and and CC cord-010119-t1x9gknd 7714 15 RHD RHD NNP cord-010119-t1x9gknd 7714 16 sequencing sequencing NN cord-010119-t1x9gknd 7714 17 for for IN cord-010119-t1x9gknd 7714 18 some some DT cord-010119-t1x9gknd 7714 19 . . . cord-010119-t1x9gknd 7715 1 Ethnicity ethnicity NN cord-010119-t1x9gknd 7715 2 was be VBD cord-010119-t1x9gknd 7715 3 known know VBN cord-010119-t1x9gknd 7715 4 for for IN cord-010119-t1x9gknd 7715 5 153 153 CD cord-010119-t1x9gknd 7715 6 samples sample NNS cord-010119-t1x9gknd 7715 7 ( ( -LRB- cord-010119-t1x9gknd 7715 8 53.3 53.3 CD cord-010119-t1x9gknd 7715 9 % % NN cord-010119-t1x9gknd 7715 10 Caucasian caucasian JJ cord-010119-t1x9gknd 7715 11 , , , cord-010119-t1x9gknd 7715 12 32.2 32.2 CD cord-010119-t1x9gknd 7715 13 % % NN cord-010119-t1x9gknd 7715 14 African african JJ cord-010119-t1x9gknd 7715 15 American american JJ cord-010119-t1x9gknd 7715 16 / / SYM cord-010119-t1x9gknd 7715 17 African african JJ cord-010119-t1x9gknd 7715 18 , , , cord-010119-t1x9gknd 7715 19 6.6 6.6 CD cord-010119-t1x9gknd 7715 20 % % NN cord-010119-t1x9gknd 7715 21 multiracial multiracial JJ cord-010119-t1x9gknd 7715 22 , , , cord-010119-t1x9gknd 7715 23 4.6 4.6 CD cord-010119-t1x9gknd 7715 24 % % NN cord-010119-t1x9gknd 7715 25 Hispanic hispanic JJ cord-010119-t1x9gknd 7715 26 , , , cord-010119-t1x9gknd 7715 27 2 2 CD cord-010119-t1x9gknd 7715 28 % % NN cord-010119-t1x9gknd 7715 29 Asian asian JJ cord-010119-t1x9gknd 7715 30 , , , cord-010119-t1x9gknd 7715 31 and and CC cord-010119-t1x9gknd 7715 32 1.3 1.3 CD cord-010119-t1x9gknd 7715 33 % % NN cord-010119-t1x9gknd 7715 34 other other JJ cord-010119-t1x9gknd 7715 35 ) ) -RRB- cord-010119-t1x9gknd 7715 36 . . . cord-010119-t1x9gknd 7716 1 Results/ Results/ . cord-010119-t1x9gknd 7717 1 Finding finding NN cord-010119-t1x9gknd 7717 2 : : : cord-010119-t1x9gknd 7718 1 RHD RHD NNP cord-010119-t1x9gknd 7718 2 genotyping genotyping NN cord-010119-t1x9gknd 7718 3 identified identify VBD cord-010119-t1x9gknd 7718 4 weak weak JJ cord-010119-t1x9gknd 7718 5 D d NN cord-010119-t1x9gknd 7718 6 types type NNS cord-010119-t1x9gknd 7718 7 1 1 CD cord-010119-t1x9gknd 7718 8 , , , cord-010119-t1x9gknd 7718 9 2 2 CD cord-010119-t1x9gknd 7718 10 , , , cord-010119-t1x9gknd 7718 11 and and CC cord-010119-t1x9gknd 7718 12 3 3 CD cord-010119-t1x9gknd 7718 13 in in IN cord-010119-t1x9gknd 7718 14 155/352 155/352 CD cord-010119-t1x9gknd 7718 15 ( ( -LRB- cord-010119-t1x9gknd 7718 16 44 44 CD cord-010119-t1x9gknd 7718 17 % % NN cord-010119-t1x9gknd 7718 18 ) ) -RRB- cord-010119-t1x9gknd 7718 19 and and CC cord-010119-t1x9gknd 7718 20 alleles allele NNS cord-010119-t1x9gknd 7718 21 known know VBN cord-010119-t1x9gknd 7718 22 to to TO cord-010119-t1x9gknd 7718 23 encode encode VB cord-010119-t1x9gknd 7718 24 partial partial JJ cord-010119-t1x9gknd 7718 25 D d NN cord-010119-t1x9gknd 7718 26 phenotypes phenotype NNS cord-010119-t1x9gknd 7718 27 in in IN cord-010119-t1x9gknd 7718 28 168/ 168/ CD cord-010119-t1x9gknd 7718 29 352 352 CD cord-010119-t1x9gknd 7718 30 ( ( -LRB- cord-010119-t1x9gknd 7718 31 47.7 47.7 CD cord-010119-t1x9gknd 7718 32 % % NN cord-010119-t1x9gknd 7718 33 ) ) -RRB- cord-010119-t1x9gknd 7718 34 ( ( -LRB- cord-010119-t1x9gknd 7718 35 Table table NN cord-010119-t1x9gknd 7718 36 ) ) -RRB- cord-010119-t1x9gknd 7718 37 . . . cord-010119-t1x9gknd 7719 1 Uncommon uncommon JJ cord-010119-t1x9gknd 7719 2 or or CC cord-010119-t1x9gknd 7719 3 rare rare JJ cord-010119-t1x9gknd 7719 4 weak weak JJ cord-010119-t1x9gknd 7719 5 D d NN cord-010119-t1x9gknd 7719 6 alleles allele NNS cord-010119-t1x9gknd 7719 7 including include VBG cord-010119-t1x9gknd 7719 8 types type NNS cord-010119-t1x9gknd 7719 9 6 6 CD cord-010119-t1x9gknd 7719 10 , , , cord-010119-t1x9gknd 7719 11 15 15 CD cord-010119-t1x9gknd 7719 12 , , , cord-010119-t1x9gknd 7719 13 40 40 CD cord-010119-t1x9gknd 7719 14 , , , cord-010119-t1x9gknd 7719 15 42 42 CD cord-010119-t1x9gknd 7719 16 , , , cord-010119-t1x9gknd 7719 17 45 45 CD cord-010119-t1x9gknd 7719 18 , , , cord-010119-t1x9gknd 7719 19 51 51 CD cord-010119-t1x9gknd 7719 20 , , , cord-010119-t1x9gknd 7719 21 57 57 CD cord-010119-t1x9gknd 7719 22 ( ( -LRB- cord-010119-t1x9gknd 7719 23 n52 n52 NNP cord-010119-t1x9gknd 7719 24 ) ) -RRB- cord-010119-t1x9gknd 7719 25 , , , cord-010119-t1x9gknd 7719 26 59 59 CD cord-010119-t1x9gknd 7719 27 , , , cord-010119-t1x9gknd 7719 28 61 61 CD cord-010119-t1x9gknd 7719 29 , , , cord-010119-t1x9gknd 7719 30 78 78 CD cord-010119-t1x9gknd 7719 31 , , , cord-010119-t1x9gknd 7719 32 91 91 CD cord-010119-t1x9gknd 7719 33 , , , cord-010119-t1x9gknd 7719 34 and and CC cord-010119-t1x9gknd 7719 35 119 119 CD cord-010119-t1x9gknd 7719 36 were be VBD cord-010119-t1x9gknd 7719 37 found find VBN cord-010119-t1x9gknd 7719 38 in in IN cord-010119-t1x9gknd 7719 39 13 13 CD cord-010119-t1x9gknd 7719 40 ( ( -LRB- cord-010119-t1x9gknd 7719 41 3.7 3.7 CD cord-010119-t1x9gknd 7719 42 % % NN cord-010119-t1x9gknd 7719 43 ) ) -RRB- cord-010119-t1x9gknd 7719 44 . . . cord-010119-t1x9gknd 7720 1 The the DT cord-010119-t1x9gknd 7720 2 partial partial JJ cord-010119-t1x9gknd 7720 3 D d NN cord-010119-t1x9gknd 7720 4 alleles allele NNS cord-010119-t1x9gknd 7720 5 found find VBN cord-010119-t1x9gknd 7720 6 were be VBD cord-010119-t1x9gknd 7720 7 diverse diverse JJ cord-010119-t1x9gknd 7720 8 , , , cord-010119-t1x9gknd 7720 9 but but CC cord-010119-t1x9gknd 7720 10 the the DT cord-010119-t1x9gknd 7720 11 largest large JJS cord-010119-t1x9gknd 7720 12 number number NN cord-010119-t1x9gknd 7720 13 included include VBD cord-010119-t1x9gknd 7720 14 partial partial JJ cord-010119-t1x9gknd 7720 15 RHD*D RHD*D NNP cord-010119-t1x9gknd 7720 16 4.0 4.0 CD cord-010119-t1x9gknd 7720 17 ( ( -LRB- cord-010119-t1x9gknd 7720 18 n562 n562 NNP cord-010119-t1x9gknd 7720 19 ) ) -RRB- cord-010119-t1x9gknd 7720 20 and and CC cord-010119-t1x9gknd 7721 1 * * NFP cord-010119-t1x9gknd 7721 2 DAR DAR NNP cord-010119-t1x9gknd 7721 3 ( ( -LRB- cord-010119-t1x9gknd 7721 4 Conclusion conclusion NN cord-010119-t1x9gknd 7721 5 : : : cord-010119-t1x9gknd 7722 1 In in IN cord-010119-t1x9gknd 7722 2 a a DT cord-010119-t1x9gknd 7722 3 multiracial multiracial JJ cord-010119-t1x9gknd 7722 4 cohort cohort NN cord-010119-t1x9gknd 7722 5 of of IN cord-010119-t1x9gknd 7722 6 352 352 CD cord-010119-t1x9gknd 7722 7 individuals individual NNS cord-010119-t1x9gknd 7722 8 with with IN cord-010119-t1x9gknd 7722 9 weaker weak JJR cord-010119-t1x9gknd 7722 10 than than IN cord-010119-t1x9gknd 7722 11 expected expect VBN cord-010119-t1x9gknd 7722 12 D d NN cord-010119-t1x9gknd 7722 13 typing type VBG cord-010119-t1x9gknd 7722 14 44 44 CD cord-010119-t1x9gknd 7722 15 % % NN cord-010119-t1x9gknd 7722 16 were be VBD cord-010119-t1x9gknd 7722 17 due due JJ cord-010119-t1x9gknd 7722 18 to to IN cord-010119-t1x9gknd 7722 19 weak weak JJ cord-010119-t1x9gknd 7722 20 D d NN cord-010119-t1x9gknd 7722 21 types type NNS cord-010119-t1x9gknd 7722 22 1 1 CD cord-010119-t1x9gknd 7722 23 , , , cord-010119-t1x9gknd 7722 24 2 2 CD cord-010119-t1x9gknd 7722 25 , , , cord-010119-t1x9gknd 7722 26 or or CC cord-010119-t1x9gknd 7722 27 3 3 CD cord-010119-t1x9gknd 7722 28 and and CC cord-010119-t1x9gknd 7722 29 would would MD cord-010119-t1x9gknd 7722 30 not not RB cord-010119-t1x9gknd 7722 31 be be VB cord-010119-t1x9gknd 7722 32 considered consider VBN cord-010119-t1x9gknd 7722 33 at at IN cord-010119-t1x9gknd 7722 34 risk risk NN cord-010119-t1x9gknd 7722 35 of of IN cord-010119-t1x9gknd 7722 36 clinical clinical JJ cord-010119-t1x9gknd 7722 37 significant significant JJ cord-010119-t1x9gknd 7722 38 anti anti JJ cord-010119-t1x9gknd 7722 39 - - JJ cord-010119-t1x9gknd 7722 40 D d JJ cord-010119-t1x9gknd 7722 41 , , , cord-010119-t1x9gknd 7722 42 but but CC cord-010119-t1x9gknd 7722 43 for for IN cord-010119-t1x9gknd 7722 44 56 56 CD cord-010119-t1x9gknd 7722 45 % % NN cord-010119-t1x9gknd 7722 46 there there EX cord-010119-t1x9gknd 7722 47 is be VBZ cord-010119-t1x9gknd 7722 48 potential potential JJ cord-010119-t1x9gknd 7722 49 or or CC cord-010119-t1x9gknd 7722 50 unknown unknown JJ cord-010119-t1x9gknd 7722 51 risk risk NN cord-010119-t1x9gknd 7722 52 . . . cord-010119-t1x9gknd 7723 1 These these DT cord-010119-t1x9gknd 7723 2 studies study NNS cord-010119-t1x9gknd 7723 3 are be VBP cord-010119-t1x9gknd 7723 4 important important JJ cord-010119-t1x9gknd 7723 5 to to TO cord-010119-t1x9gknd 7723 6 gain gain VB cord-010119-t1x9gknd 7723 7 insight insight NN cord-010119-t1x9gknd 7723 8 into into IN cord-010119-t1x9gknd 7723 9 the the DT cord-010119-t1x9gknd 7723 10 prevalence prevalence NN cord-010119-t1x9gknd 7723 11 of of IN cord-010119-t1x9gknd 7723 12 specific specific JJ cord-010119-t1x9gknd 7723 13 alleles allele NNS cord-010119-t1x9gknd 7723 14 in in IN cord-010119-t1x9gknd 7723 15 the the DT cord-010119-t1x9gknd 7723 16 U.S. U.S. NNP cord-010119-t1x9gknd 7723 17 multiethnic multiethnic JJ cord-010119-t1x9gknd 7723 18 population population NN cord-010119-t1x9gknd 7723 19 and and CC cord-010119-t1x9gknd 7723 20 to to TO cord-010119-t1x9gknd 7723 21 continue continue VB cord-010119-t1x9gknd 7723 22 to to TO cord-010119-t1x9gknd 7723 23 evaluate evaluate VB cord-010119-t1x9gknd 7723 24 and and CC cord-010119-t1x9gknd 7723 25 refine refine VB cord-010119-t1x9gknd 7723 26 RHD RHD NNP cord-010119-t1x9gknd 7723 27 genotyping genotyping NN cord-010119-t1x9gknd 7723 28 for for IN cord-010119-t1x9gknd 7723 29 clinical clinical JJ cord-010119-t1x9gknd 7723 30 practice practice NN cord-010119-t1x9gknd 7723 31 . . . cord-010119-t1x9gknd 7724 1 CP242 CP242 NNP cord-010119-t1x9gknd 7724 2 RHD*07.02 RHD*07.02 NNP cord-010119-t1x9gknd 7725 1 Allele allele NN cord-010119-t1x9gknd 7725 2 Causes cause VBZ cord-010119-t1x9gknd 7725 3 Discrepant Discrepant NNP cord-010119-t1x9gknd 7725 4 Genotyping Genotyping NNP cord-010119-t1x9gknd 7725 5 Results Results NNPS cord-010119-t1x9gknd 7725 6 for for IN cord-010119-t1x9gknd 7725 7 RHCE RHCE NNP cord-010119-t1x9gknd 7725 8 SMALL SMALL NNP cord-010119-t1x9gknd 7725 9 C C NNP cord-010119-t1x9gknd 7725 10 Sabine Sabine NNP cord-010119-t1x9gknd 7725 11 Scholz Scholz NNP cord-010119-t1x9gknd 7726 1 * * NFP cord-010119-t1x9gknd 7726 2 1 1 CD cord-010119-t1x9gknd 7726 3 , , , cord-010119-t1x9gknd 7726 4 Sandra Sandra NNP cord-010119-t1x9gknd 7726 5 Schneider Schneider NNP cord-010119-t1x9gknd 7726 6 1 1 CD cord-010119-t1x9gknd 7726 7 , , , cord-010119-t1x9gknd 7726 8 Sabrina Sabrina NNP cord-010119-t1x9gknd 7726 9 K€ K€ NNP cord-010119-t1x9gknd 7726 10 onig onig NN cord-010119-t1x9gknd 7726 11 1 1 CD cord-010119-t1x9gknd 7726 12 , , , cord-010119-t1x9gknd 7726 13 Susanne Susanne NNP cord-010119-t1x9gknd 7726 14 Helmig Helmig NNP cord-010119-t1x9gknd 7726 15 1 1 CD cord-010119-t1x9gknd 7726 16 and and CC cord-010119-t1x9gknd 7726 17 Vicky Vicky NNP cord-010119-t1x9gknd 7726 18 van van NNP cord-010119-t1x9gknd 7726 19 Sandt Sandt NNP cord-010119-t1x9gknd 7726 20 2 2 CD cord-010119-t1x9gknd 7726 21 . . . cord-010119-t1x9gknd 7727 1 1 1 CD cord-010119-t1x9gknd 7727 2 inno inno JJ cord-010119-t1x9gknd 7727 3 - - NN cord-010119-t1x9gknd 7727 4 train train NN cord-010119-t1x9gknd 7727 5 Diagnostik Diagnostik NNP cord-010119-t1x9gknd 7727 6 GmbH GmbH NNP cord-010119-t1x9gknd 7727 7 , , , cord-010119-t1x9gknd 7727 8 2 2 CD cord-010119-t1x9gknd 7727 9 Rode ride VBD cord-010119-t1x9gknd 7727 10 Kruis Kruis NNP cord-010119-t1x9gknd 7727 11 Vlaanderen Vlaanderen NNP cord-010119-t1x9gknd 7727 12 Background Background NNP cord-010119-t1x9gknd 7727 13 / / SYM cord-010119-t1x9gknd 7727 14 Case Case NNP cord-010119-t1x9gknd 7727 15 Studies Studies NNPS cord-010119-t1x9gknd 7727 16 : : : cord-010119-t1x9gknd 7727 17 In in IN cord-010119-t1x9gknd 7727 18 the the DT cord-010119-t1x9gknd 7727 19 human human JJ cord-010119-t1x9gknd 7727 20 Rh Rh NNP cord-010119-t1x9gknd 7727 21 blood blood NN cord-010119-t1x9gknd 7727 22 group group NN cord-010119-t1x9gknd 7727 23 system system NN cord-010119-t1x9gknd 7727 24 the the DT cord-010119-t1x9gknd 7727 25 c c NNP cord-010119-t1x9gknd 7727 26 , , , cord-010119-t1x9gknd 7727 27 C C NNP cord-010119-t1x9gknd 7727 28 , , , cord-010119-t1x9gknd 7727 29 E E NNP cord-010119-t1x9gknd 7727 30 , , , cord-010119-t1x9gknd 7727 31 e e NN cord-010119-t1x9gknd 7727 32 and and CC cord-010119-t1x9gknd 7727 33 D d NN cord-010119-t1x9gknd 7727 34 antigens antigen NNS cord-010119-t1x9gknd 7727 35 are be VBP cord-010119-t1x9gknd 7727 36 expressed express VBN cord-010119-t1x9gknd 7727 37 by by IN cord-010119-t1x9gknd 7727 38 the the DT cord-010119-t1x9gknd 7727 39 two two CD cord-010119-t1x9gknd 7727 40 highly highly RB cord-010119-t1x9gknd 7727 41 homologous homologous JJ cord-010119-t1x9gknd 7727 42 genes gene NNS cord-010119-t1x9gknd 7727 43 RHCE RHCE NNP cord-010119-t1x9gknd 7727 44 and and CC cord-010119-t1x9gknd 7727 45 RHD RHD NNP cord-010119-t1x9gknd 7727 46 . . . cord-010119-t1x9gknd 7728 1 After after IN cord-010119-t1x9gknd 7728 2 D D NNP cord-010119-t1x9gknd 7728 3 , , , cord-010119-t1x9gknd 7728 4 c c NNP cord-010119-t1x9gknd 7728 5 is be VBZ cord-010119-t1x9gknd 7728 6 the the DT cord-010119-t1x9gknd 7728 7 most most RBS cord-010119-t1x9gknd 7728 8 immunogenic immunogenic JJ cord-010119-t1x9gknd 7728 9 Rh Rh NNP cord-010119-t1x9gknd 7728 10 antigen antigen NN cord-010119-t1x9gknd 7728 11 . . . cord-010119-t1x9gknd 7729 1 The the DT cord-010119-t1x9gknd 7729 2 difference difference NN cord-010119-t1x9gknd 7729 3 between between IN cord-010119-t1x9gknd 7729 4 c c NN cord-010119-t1x9gknd 7729 5 ( ( -LRB- cord-010119-t1x9gknd 7729 6 307C 307C NNP cord-010119-t1x9gknd 7729 7 ) ) -RRB- cord-010119-t1x9gknd 7729 8 and and CC cord-010119-t1x9gknd 7729 9 C C NNP cord-010119-t1x9gknd 7729 10 ( ( -LRB- cord-010119-t1x9gknd 7729 11 307 307 CD cord-010119-t1x9gknd 7729 12 T t NN cord-010119-t1x9gknd 7729 13 ) ) -RRB- cord-010119-t1x9gknd 7729 14 is be VBZ cord-010119-t1x9gknd 7729 15 caused cause VBN cord-010119-t1x9gknd 7729 16 by by IN cord-010119-t1x9gknd 7729 17 the the DT cord-010119-t1x9gknd 7729 18 SNP SNP NNP cord-010119-t1x9gknd 7729 19 on on IN cord-010119-t1x9gknd 7729 20 position position NN cord-010119-t1x9gknd 7729 21 307 307 CD cord-010119-t1x9gknd 7729 22 on on IN cord-010119-t1x9gknd 7729 23 the the DT cord-010119-t1x9gknd 7729 24 RHCE RHCE NNP cord-010119-t1x9gknd 7729 25 gene gene NN cord-010119-t1x9gknd 7729 26 . . . cord-010119-t1x9gknd 7730 1 The the DT cord-010119-t1x9gknd 7730 2 RHD*07.02 rhd*07.02 JJ cord-010119-t1x9gknd 7730 3 allele allele NN cord-010119-t1x9gknd 7730 4 ( ( -LRB- cord-010119-t1x9gknd 7730 5 also also RB cord-010119-t1x9gknd 7730 6 known know VBN cord-010119-t1x9gknd 7730 7 as as IN cord-010119-t1x9gknd 7730 8 RHD RHD NNP cord-010119-t1x9gknd 7730 9 cat cat NN cord-010119-t1x9gknd 7730 10 VII VII NNP cord-010119-t1x9gknd 7730 11 type type NN cord-010119-t1x9gknd 7730 12 2 2 CD cord-010119-t1x9gknd 7730 13 ) ) -RRB- cord-010119-t1x9gknd 7730 14 carries carry VBZ cord-010119-t1x9gknd 7730 15 the the DT cord-010119-t1x9gknd 7730 16 SNP SNP NNP cord-010119-t1x9gknd 7730 17 307 307 CD cord-010119-t1x9gknd 7730 18 T T NNP cord-010119-t1x9gknd 7731 1 > > XX cord-010119-t1x9gknd 7732 1 C C NNP cord-010119-t1x9gknd 7732 2 on on IN cord-010119-t1x9gknd 7732 3 the the DT cord-010119-t1x9gknd 7732 4 RHD RHD NNP cord-010119-t1x9gknd 7732 5 gene gene NN cord-010119-t1x9gknd 7732 6 and and CC cord-010119-t1x9gknd 7732 7 additionally additionally RB cord-010119-t1x9gknd 7732 8 the the DT cord-010119-t1x9gknd 7732 9 SNP SNP NNP cord-010119-t1x9gknd 7732 10 329 329 CD cord-010119-t1x9gknd 7732 11 T T NNP cord-010119-t1x9gknd 7733 1 > > XX cord-010119-t1x9gknd 7734 1 C. C. NNP cord-010119-t1x9gknd 7735 1 This this DT cord-010119-t1x9gknd 7735 2 RHD*07.02 rhd*07.02 NN cord-010119-t1x9gknd 7735 3 allele allele NN cord-010119-t1x9gknd 7735 4 has have VBZ cord-010119-t1x9gknd 7735 5 been be VBN cord-010119-t1x9gknd 7735 6 described describe VBN cord-010119-t1x9gknd 7735 7 to to TO cord-010119-t1x9gknd 7735 8 partially partially RB cord-010119-t1x9gknd 7735 9 express express VB cord-010119-t1x9gknd 7735 10 RHc RHc NNS cord-010119-t1x9gknd 7735 11 on on IN cord-010119-t1x9gknd 7735 12 the the DT cord-010119-t1x9gknd 7735 13 D d NN cord-010119-t1x9gknd 7735 14 polypeptide polypeptide NN cord-010119-t1x9gknd 7735 15 ( ( -LRB- cord-010119-t1x9gknd 7735 16 Faas Faas NNP cord-010119-t1x9gknd 7735 17 , , , cord-010119-t1x9gknd 7735 18 Transfusion Transfusion NNP cord-010119-t1x9gknd 7735 19 , , , cord-010119-t1x9gknd 7735 20 2001 2001 CD cord-010119-t1x9gknd 7735 21 ) ) -RRB- cord-010119-t1x9gknd 7735 22 . . . cord-010119-t1x9gknd 7736 1 Aims aim VBZ cord-010119-t1x9gknd 7736 2 : : : cord-010119-t1x9gknd 7737 1 Genotyping Genotyping NNP cord-010119-t1x9gknd 7737 2 was be VBD cord-010119-t1x9gknd 7737 3 performed perform VBN cord-010119-t1x9gknd 7737 4 to to TO cord-010119-t1x9gknd 7737 5 clarify clarify VB cord-010119-t1x9gknd 7737 6 the the DT cord-010119-t1x9gknd 7737 7 cause cause NN cord-010119-t1x9gknd 7737 8 of of IN cord-010119-t1x9gknd 7737 9 the the DT cord-010119-t1x9gknd 7737 10 weak weak JJ cord-010119-t1x9gknd 7737 11 c c NNP cord-010119-t1x9gknd 7737 12 expression expression NN cord-010119-t1x9gknd 7737 13 . . . cord-010119-t1x9gknd 7738 1 Serology serology NN cord-010119-t1x9gknd 7738 2 of of IN cord-010119-t1x9gknd 7738 3 a a DT cord-010119-t1x9gknd 7738 4 patient patient JJ cord-010119-t1x9gknd 7738 5 sample sample NN cord-010119-t1x9gknd 7738 6 ( ( -LRB- cord-010119-t1x9gknd 7738 7 Male Male NNP cord-010119-t1x9gknd 7738 8 , , , cord-010119-t1x9gknd 7738 9 81938 81938 CD cord-010119-t1x9gknd 7738 10 ) ) -RRB- cord-010119-t1x9gknd 7738 11 indicated indicate VBD cord-010119-t1x9gknd 7738 12 a a DT cord-010119-t1x9gknd 7738 13 partial partial JJ cord-010119-t1x9gknd 7738 14 c c NN cord-010119-t1x9gknd 7738 15 phenotype phenotype NN cord-010119-t1x9gknd 7738 16 with with IN cord-010119-t1x9gknd 7738 17 a a DT cord-010119-t1x9gknd 7738 18 CDe cde NN cord-010119-t1x9gknd 7738 19 . . . cord-010119-t1x9gknd 7739 1 Study Study NNP cord-010119-t1x9gknd 7739 2 Design Design NNP cord-010119-t1x9gknd 7739 3 / / SYM cord-010119-t1x9gknd 7739 4 Method method NN cord-010119-t1x9gknd 7739 5 : : : cord-010119-t1x9gknd 7740 1 RhD RhD NNP cord-010119-t1x9gknd 7740 2 and and CC cord-010119-t1x9gknd 7740 3 RhCE RhCE NNP cord-010119-t1x9gknd 7740 4 phenotyping phenotyping NN cord-010119-t1x9gknd 7740 5 was be VBD cord-010119-t1x9gknd 7740 6 done do VBN cord-010119-t1x9gknd 7740 7 by by IN cord-010119-t1x9gknd 7740 8 accredited accredited JJ cord-010119-t1x9gknd 7740 9 routine routine JJ cord-010119-t1x9gknd 7740 10 protocols protocol NNS cord-010119-t1x9gknd 7740 11 ( ( -LRB- cord-010119-t1x9gknd 7740 12 monoclonal monoclonal JJ cord-010119-t1x9gknd 7740 13 AB ab NN cord-010119-t1x9gknd 7740 14 ID ID NNP cord-010119-t1x9gknd 7740 15 card card NN cord-010119-t1x9gknd 7740 16 : : : cord-010119-t1x9gknd 7740 17 Diaclon Diaclon NNP cord-010119-t1x9gknd 7740 18 Rh Rh NNP cord-010119-t1x9gknd 7740 19 subgroups subgroup NNS cord-010119-t1x9gknd 7740 20 , , , cord-010119-t1x9gknd 7740 21 seraclone seraclone NNP cord-010119-t1x9gknd 7740 22 anti anti NNP cord-010119-t1x9gknd 7740 23 - - NNP cord-010119-t1x9gknd 7740 24 c c NNP cord-010119-t1x9gknd 7740 25 ) ) -RRB- cord-010119-t1x9gknd 7740 26 . . . cord-010119-t1x9gknd 7741 1 Genotyping Genotyping NNP cord-010119-t1x9gknd 7741 2 was be VBD cord-010119-t1x9gknd 7741 3 performed perform VBN cord-010119-t1x9gknd 7741 4 with with IN cord-010119-t1x9gknd 7741 5 a a DT cord-010119-t1x9gknd 7741 6 TaqMan TaqMan NNP cord-010119-t1x9gknd 7741 7 Probe Probe NNP cord-010119-t1x9gknd 7741 8 assay assay NN cord-010119-t1x9gknd 7741 9 ( ( -LRB- cord-010119-t1x9gknd 7741 10 RBC RBC NNP cord-010119-t1x9gknd 7741 11 - - HYPH cord-010119-t1x9gknd 7741 12 FluoGene FluoGene NNP cord-010119-t1x9gknd 7741 13 vERYfy veryfy NN cord-010119-t1x9gknd 7741 14 , , , cord-010119-t1x9gknd 7741 15 inno inno JJ cord-010119-t1x9gknd 7741 16 - - NN cord-010119-t1x9gknd 7741 17 train train NN cord-010119-t1x9gknd 7741 18 Diagnostik Diagnostik NNP cord-010119-t1x9gknd 7741 19 GmbH GmbH NNP cord-010119-t1x9gknd 7741 20 ) ) -RRB- cord-010119-t1x9gknd 7741 21 , , , cord-010119-t1x9gknd 7741 22 SSO SSO NNP cord-010119-t1x9gknd 7741 23 ( ( -LRB- cord-010119-t1x9gknd 7741 24 RBC RBC NNP cord-010119-t1x9gknd 7741 25 - - HYPH cord-010119-t1x9gknd 7741 26 Lifecodes Lifecodes NNP cord-010119-t1x9gknd 7741 27 , , , cord-010119-t1x9gknd 7741 28 Gen Gen NNP cord-010119-t1x9gknd 7741 29 - - HYPH cord-010119-t1x9gknd 7741 30 Probe Probe NNP cord-010119-t1x9gknd 7741 31 Inc. Inc. NNP cord-010119-t1x9gknd 7741 32 ) ) -RRB- cord-010119-t1x9gknd 7741 33 , , , cord-010119-t1x9gknd 7741 34 in in IN cord-010119-t1x9gknd 7741 35 - - HYPH cord-010119-t1x9gknd 7741 36 house house NN cord-010119-t1x9gknd 7741 37 SSP SSP NNP cord-010119-t1x9gknd 7741 38 - - HYPH cord-010119-t1x9gknd 7741 39 PCR PCR NNP cord-010119-t1x9gknd 7741 40 ( ( -LRB- cord-010119-t1x9gknd 7741 41 HILA HILA NNP cord-010119-t1x9gknd 7741 42 , , , cord-010119-t1x9gknd 7741 43 Rode Rode NNP cord-010119-t1x9gknd 7741 44 Kruis Kruis NNP cord-010119-t1x9gknd 7741 45 - - HYPH cord-010119-t1x9gknd 7741 46 Vlaanderen Vlaanderen NNP cord-010119-t1x9gknd 7741 47 ) ) -RRB- cord-010119-t1x9gknd 7741 48 and and CC cord-010119-t1x9gknd 7741 49 commercial commercial JJ cord-010119-t1x9gknd 7741 50 SSP SSP NNP cord-010119-t1x9gknd 7741 51 - - HYPH cord-010119-t1x9gknd 7741 52 PCR PCR NNP cord-010119-t1x9gknd 7741 53 ( ( -LRB- cord-010119-t1x9gknd 7741 54 RBC RBC NNP cord-010119-t1x9gknd 7741 55 - - HYPH cord-010119-t1x9gknd 7741 56 Ready Ready NNP cord-010119-t1x9gknd 7741 57 Gene Gene NNP cord-010119-t1x9gknd 7741 58 CDE CDE NNP cord-010119-t1x9gknd 7741 59 , , , cord-010119-t1x9gknd 7741 60 inno inno JJ cord-010119-t1x9gknd 7741 61 - - NN cord-010119-t1x9gknd 7741 62 train train NN cord-010119-t1x9gknd 7741 63 Diagnostik Diagnostik NNP cord-010119-t1x9gknd 7741 64 GmbH GmbH NNP cord-010119-t1x9gknd 7741 65 ) ) -RRB- cord-010119-t1x9gknd 7741 66 . . . cord-010119-t1x9gknd 7742 1 Sanger Sanger NNP cord-010119-t1x9gknd 7742 2 sequencing sequencing NN cord-010119-t1x9gknd 7742 3 of of IN cord-010119-t1x9gknd 7742 4 the the DT cord-010119-t1x9gknd 7742 5 RHD RHD NNP cord-010119-t1x9gknd 7742 6 gene gene NN cord-010119-t1x9gknd 7742 7 was be VBD cord-010119-t1x9gknd 7742 8 performed perform VBN cord-010119-t1x9gknd 7742 9 using use VBG cord-010119-t1x9gknd 7742 10 an an DT cord-010119-t1x9gknd 7742 11 inhouse inhouse NN cord-010119-t1x9gknd 7742 12 method method NN cord-010119-t1x9gknd 7742 13 ( ( -LRB- cord-010119-t1x9gknd 7742 14 inno inno JJ cord-010119-t1x9gknd 7742 15 - - JJ cord-010119-t1x9gknd 7742 16 train train NN cord-010119-t1x9gknd 7742 17 Diagnostik Diagnostik NNP cord-010119-t1x9gknd 7742 18 GmbH GmbH NNP cord-010119-t1x9gknd 7742 19 ) ) -RRB- cord-010119-t1x9gknd 7742 20 . . . cord-010119-t1x9gknd 7743 1 Results/ Results/ . cord-010119-t1x9gknd 7744 1 Finding find VBG cord-010119-t1x9gknd 7744 2 : : : cord-010119-t1x9gknd 7744 3 Discrepant discrepant JJ cord-010119-t1x9gknd 7744 4 genotyping genotyping NN cord-010119-t1x9gknd 7744 5 results result NNS cord-010119-t1x9gknd 7744 6 were be VBD cord-010119-t1x9gknd 7744 7 generated generate VBN cord-010119-t1x9gknd 7744 8 by by IN cord-010119-t1x9gknd 7744 9 different different JJ cord-010119-t1x9gknd 7744 10 test test NN cord-010119-t1x9gknd 7744 11 systems system NNS cord-010119-t1x9gknd 7744 12 : : : cord-010119-t1x9gknd 7744 13 the the DT cord-010119-t1x9gknd 7744 14 TaqMan TaqMan NNP cord-010119-t1x9gknd 7744 15 Probe Probe NNP cord-010119-t1x9gknd 7744 16 based base VBN cord-010119-t1x9gknd 7744 17 assay assay NN cord-010119-t1x9gknd 7744 18 showed show VBD cord-010119-t1x9gknd 7744 19 in in IN cord-010119-t1x9gknd 7744 20 repetition repetition NN cord-010119-t1x9gknd 7744 21 a a DT cord-010119-t1x9gknd 7744 22 CCee CCee NNP cord-010119-t1x9gknd 7744 23 genotype genotype NN cord-010119-t1x9gknd 7744 24 , , , cord-010119-t1x9gknd 7744 25 while while IN cord-010119-t1x9gknd 7744 26 the the DT cord-010119-t1x9gknd 7744 27 SSO SSO NNP cord-010119-t1x9gknd 7744 28 system system NN cord-010119-t1x9gknd 7744 29 RBC RBC NNP cord-010119-t1x9gknd 7744 30 - - HYPH cord-010119-t1x9gknd 7744 31 Lifecodes Lifecodes NNP cord-010119-t1x9gknd 7744 32 predicted predict VBD cord-010119-t1x9gknd 7744 33 in in IN cord-010119-t1x9gknd 7744 34 repetition repetition NN cord-010119-t1x9gknd 7744 35 a a DT cord-010119-t1x9gknd 7744 36 Ccee Ccee NNP cord-010119-t1x9gknd 7744 37 phenotype phenotype NN cord-010119-t1x9gknd 7744 38 . . . cord-010119-t1x9gknd 7745 1 In in IN cord-010119-t1x9gknd 7745 2 SSP SSP NNP cord-010119-t1x9gknd 7745 3 - - HYPH cord-010119-t1x9gknd 7745 4 PCR PCR NNP cord-010119-t1x9gknd 7745 5 the the DT cord-010119-t1x9gknd 7745 6 sample sample NN cord-010119-t1x9gknd 7745 7 showed show VBD cord-010119-t1x9gknd 7745 8 a a DT cord-010119-t1x9gknd 7745 9 weak weak JJ cord-010119-t1x9gknd 7745 10 c c NN cord-010119-t1x9gknd 7745 11 band band NN cord-010119-t1x9gknd 7745 12 with with IN cord-010119-t1x9gknd 7745 13 the the DT cord-010119-t1x9gknd 7745 14 in in IN cord-010119-t1x9gknd 7745 15 - - HYPH cord-010119-t1x9gknd 7745 16 house house NN cord-010119-t1x9gknd 7745 17 method method NN cord-010119-t1x9gknd 7745 18 , , , cord-010119-t1x9gknd 7745 19 while while IN cord-010119-t1x9gknd 7745 20 there there EX cord-010119-t1x9gknd 7745 21 was be VBD cord-010119-t1x9gknd 7745 22 no no DT cord-010119-t1x9gknd 7745 23 band band NN cord-010119-t1x9gknd 7745 24 visible visible JJ cord-010119-t1x9gknd 7745 25 with with IN cord-010119-t1x9gknd 7745 26 the the DT cord-010119-t1x9gknd 7745 27 commercial commercial JJ cord-010119-t1x9gknd 7745 28 test test NN cord-010119-t1x9gknd 7745 29 kit kit NN cord-010119-t1x9gknd 7745 30 . . . cord-010119-t1x9gknd 7746 1 The the DT cord-010119-t1x9gknd 7746 2 parallel parallel JJ cord-010119-t1x9gknd 7746 3 analysis analysis NN cord-010119-t1x9gknd 7746 4 of of IN cord-010119-t1x9gknd 7746 5 the the DT cord-010119-t1x9gknd 7746 6 RHD RHD NNP cord-010119-t1x9gknd 7746 7 gene gene NN cord-010119-t1x9gknd 7746 8 with with IN cord-010119-t1x9gknd 7746 9 RBC RBC NNP cord-010119-t1x9gknd 7746 10 - - HYPH cord-010119-t1x9gknd 7746 11 Ready Ready NNP cord-010119-t1x9gknd 7746 12 Gene Gene NNP cord-010119-t1x9gknd 7746 13 CDE CDE NNP cord-010119-t1x9gknd 7746 14 test test NN cord-010119-t1x9gknd 7746 15 system system NN cord-010119-t1x9gknd 7746 16 revealed reveal VBD cord-010119-t1x9gknd 7746 17 a a DT cord-010119-t1x9gknd 7746 18 variant variant JJ cord-010119-t1x9gknd 7746 19 D d NN cord-010119-t1x9gknd 7746 20 cat cat NN cord-010119-t1x9gknd 7746 21 VII VII NNP cord-010119-t1x9gknd 7746 22 RHD RHD NNP cord-010119-t1x9gknd 7746 23 allele allele NN cord-010119-t1x9gknd 7746 24 . . . cord-010119-t1x9gknd 7747 1 Sequencing sequencing NN cord-010119-t1x9gknd 7747 2 of of IN cord-010119-t1x9gknd 7747 3 the the DT cord-010119-t1x9gknd 7747 4 DNA dna NN cord-010119-t1x9gknd 7747 5 sample sample NN cord-010119-t1x9gknd 7747 6 identified identify VBD cord-010119-t1x9gknd 7747 7 two two CD cord-010119-t1x9gknd 7747 8 SNPs snp NNS cord-010119-t1x9gknd 7747 9 on on IN cord-010119-t1x9gknd 7747 10 one one CD cord-010119-t1x9gknd 7747 11 of of IN cord-010119-t1x9gknd 7747 12 the the DT cord-010119-t1x9gknd 7747 13 RHD RHD NNP cord-010119-t1x9gknd 7747 14 alleles allele NNS cord-010119-t1x9gknd 7747 15 ( ( -LRB- cord-010119-t1x9gknd 7747 16 307 307 CD cord-010119-t1x9gknd 7747 17 T t NN cord-010119-t1x9gknd 7748 1 > > XX cord-010119-t1x9gknd 7749 1 C C NNP cord-010119-t1x9gknd 7749 2 , , , cord-010119-t1x9gknd 7749 3 329 329 CD cord-010119-t1x9gknd 7749 4 T t NN cord-010119-t1x9gknd 7750 1 > > XX cord-010119-t1x9gknd 7750 2 C C NNP cord-010119-t1x9gknd 7750 3 ) ) -RRB- cord-010119-t1x9gknd 7750 4 confirming confirm VBG cord-010119-t1x9gknd 7750 5 a a DT cord-010119-t1x9gknd 7750 6 RHD*07.02 rhd*07.02 NN cord-010119-t1x9gknd 7750 7 and and CC cord-010119-t1x9gknd 7750 8 one one CD cord-010119-t1x9gknd 7750 9 RHD*01 rhd*01 CD cord-010119-t1x9gknd 7750 10 allele allele NN cord-010119-t1x9gknd 7750 11 . . . cord-010119-t1x9gknd 7751 1 Hispanic hispanic JJ cord-010119-t1x9gknd 7751 2 female female NN cord-010119-t1x9gknd 7751 3 in in IN cord-010119-t1x9gknd 7751 4 preparation preparation NN cord-010119-t1x9gknd 7751 5 for for IN cord-010119-t1x9gknd 7751 6 surgery surgery NN cord-010119-t1x9gknd 7751 7 resulted result VBD cord-010119-t1x9gknd 7751 8 in in IN cord-010119-t1x9gknd 7751 9 variable variable JJ cord-010119-t1x9gknd 7751 10 reactivity reactivity NN cord-010119-t1x9gknd 7751 11 and and CC cord-010119-t1x9gknd 7751 12 weakly weakly RB cord-010119-t1x9gknd 7751 13 positive positive JJ cord-010119-t1x9gknd 7751 14 D d NN cord-010119-t1x9gknd 7751 15 reactions reaction NNS cord-010119-t1x9gknd 7751 16 when when WRB cord-010119-t1x9gknd 7751 17 using use VBG cord-010119-t1x9gknd 7751 18 microtiter microtiter NN cord-010119-t1x9gknd 7751 19 - - HYPH cord-010119-t1x9gknd 7751 20 well well JJ cord-010119-t1x9gknd 7751 21 agglutination agglutination NN cord-010119-t1x9gknd 7751 22 versus versus IN cord-010119-t1x9gknd 7751 23 tube tube NN cord-010119-t1x9gknd 7751 24 testing testing NN cord-010119-t1x9gknd 7751 25 . . . cord-010119-t1x9gknd 7752 1 Determination determination NN cord-010119-t1x9gknd 7752 2 of of IN cord-010119-t1x9gknd 7752 3 whether whether IN cord-010119-t1x9gknd 7752 4 the the DT cord-010119-t1x9gknd 7752 5 D D NNP cord-010119-t1x9gknd 7752 6 antigen antigen NN cord-010119-t1x9gknd 7752 7 expression expression NN cord-010119-t1x9gknd 7752 8 represented represent VBD cord-010119-t1x9gknd 7752 9 a a DT cord-010119-t1x9gknd 7752 10 weak weak JJ cord-010119-t1x9gknd 7752 11 D d NN cord-010119-t1x9gknd 7752 12 or or CC cord-010119-t1x9gknd 7752 13 a a DT cord-010119-t1x9gknd 7752 14 variant variant NN cord-010119-t1x9gknd 7752 15 D d NN cord-010119-t1x9gknd 7752 16 could could MD cord-010119-t1x9gknd 7752 17 not not RB cord-010119-t1x9gknd 7752 18 be be VB cord-010119-t1x9gknd 7752 19 resolved resolve VBN cord-010119-t1x9gknd 7752 20 by by IN cord-010119-t1x9gknd 7752 21 serologic serologic NNP cord-010119-t1x9gknd 7752 22 testing testing NN cord-010119-t1x9gknd 7752 23 alone alone RB cord-010119-t1x9gknd 7752 24 . . . cord-010119-t1x9gknd 7753 1 Here here RB cord-010119-t1x9gknd 7753 2 we -PRON- PRP cord-010119-t1x9gknd 7753 3 report report VBP cord-010119-t1x9gknd 7753 4 the the DT cord-010119-t1x9gknd 7753 5 characterization characterization NN cord-010119-t1x9gknd 7753 6 of of IN cord-010119-t1x9gknd 7753 7 a a DT cord-010119-t1x9gknd 7753 8 novel novel JJ cord-010119-t1x9gknd 7753 9 RHD RHD NNP cord-010119-t1x9gknd 7753 10 gene gene NN cord-010119-t1x9gknd 7753 11 mutation mutation NN cord-010119-t1x9gknd 7753 12 identified identify VBN cord-010119-t1x9gknd 7753 13 by by IN cord-010119-t1x9gknd 7753 14 RHD RHD NNP cord-010119-t1x9gknd 7753 15 gene gene NN cord-010119-t1x9gknd 7753 16 sequencing sequencing NN cord-010119-t1x9gknd 7753 17 . . . cord-010119-t1x9gknd 7754 1 Study Study NNP cord-010119-t1x9gknd 7754 2 Design Design NNP cord-010119-t1x9gknd 7754 3 / / SYM cord-010119-t1x9gknd 7754 4 Method method NN cord-010119-t1x9gknd 7754 5 : : : cord-010119-t1x9gknd 7754 6 Serologic Serologic NNP cord-010119-t1x9gknd 7754 7 typing typing NN cord-010119-t1x9gknd 7754 8 was be VBD cord-010119-t1x9gknd 7754 9 initially initially RB cord-010119-t1x9gknd 7754 10 performed perform VBN cord-010119-t1x9gknd 7754 11 by by IN cord-010119-t1x9gknd 7754 12 microtiter microtiter NN cord-010119-t1x9gknd 7754 13 - - HYPH cord-010119-t1x9gknd 7754 14 well well JJ cord-010119-t1x9gknd 7754 15 agglutination agglutination NN cord-010119-t1x9gknd 7754 16 by by IN cord-010119-t1x9gknd 7754 17 automated automated JJ cord-010119-t1x9gknd 7754 18 analyzer analyzer NN cord-010119-t1x9gknd 7754 19 platforms platform NNS cord-010119-t1x9gknd 7754 20 Galileo Galileo NNP cord-010119-t1x9gknd 7754 21 NEO NEO NNP cord-010119-t1x9gknd 7754 22 and and CC cord-010119-t1x9gknd 7754 23 Galileo Galileo NNP cord-010119-t1x9gknd 7754 24 Echo Echo NNP cord-010119-t1x9gknd 7755 1 ( ( -LRB- cord-010119-t1x9gknd 7755 2 Immucor Immucor NNP cord-010119-t1x9gknd 7755 3 , , , cord-010119-t1x9gknd 7755 4 Norcross Norcross NNP cord-010119-t1x9gknd 7755 5 , , , cord-010119-t1x9gknd 7755 6 GA GA NNP cord-010119-t1x9gknd 7755 7 ) ) -RRB- cord-010119-t1x9gknd 7755 8 and and CC cord-010119-t1x9gknd 7755 9 by by IN cord-010119-t1x9gknd 7755 10 standard standard JJ cord-010119-t1x9gknd 7755 11 tube tube NN cord-010119-t1x9gknd 7755 12 testing testing NN cord-010119-t1x9gknd 7755 13 using use VBG cord-010119-t1x9gknd 7755 14 the the DT cord-010119-t1x9gknd 7755 15 Immucor Immucor NNP cord-010119-t1x9gknd 7755 16 Series Series NNP cord-010119-t1x9gknd 7755 17 4 4 CD cord-010119-t1x9gknd 7755 18 and and CC cord-010119-t1x9gknd 7755 19 5 5 CD cord-010119-t1x9gknd 7755 20 anti anti JJ cord-010119-t1x9gknd 7755 21 - - JJ cord-010119-t1x9gknd 7755 22 D d JJ cord-010119-t1x9gknd 7755 23 reagents reagent NNS cord-010119-t1x9gknd 7755 24 . . . cord-010119-t1x9gknd 7756 1 Further further JJ cord-010119-t1x9gknd 7756 2 immunohematologic immunohematologic JJ cord-010119-t1x9gknd 7756 3 evaluation evaluation NN cord-010119-t1x9gknd 7756 4 was be VBD cord-010119-t1x9gknd 7756 5 performed perform VBN cord-010119-t1x9gknd 7756 6 by by IN cord-010119-t1x9gknd 7756 7 standard standard JJ cord-010119-t1x9gknd 7756 8 tube tube NN cord-010119-t1x9gknd 7756 9 testing testing NN cord-010119-t1x9gknd 7756 10 ( ( -LRB- cord-010119-t1x9gknd 7756 11 immediate immediate JJ cord-010119-t1x9gknd 7756 12 spin spin NN cord-010119-t1x9gknd 7756 13 -IS -is NN cord-010119-t1x9gknd 7756 14 , , , cord-010119-t1x9gknd 7756 15 and and CC cord-010119-t1x9gknd 7756 16 indirect indirect JJ cord-010119-t1x9gknd 7756 17 antiglobulin antiglobulin NN cord-010119-t1x9gknd 7756 18 -IAT -IAT '' cord-010119-t1x9gknd 7756 19 ) ) -RRB- cord-010119-t1x9gknd 7756 20 using use VBG cord-010119-t1x9gknd 7756 21 OrthoBioclone OrthoBioclone NNP cord-010119-t1x9gknd 7756 22 , , , cord-010119-t1x9gknd 7756 23 Immucor Immucor NNP cord-010119-t1x9gknd 7756 24 Gammaclone Gammaclone NNP cord-010119-t1x9gknd 7756 25 , , , cord-010119-t1x9gknd 7756 26 Immucor Immucor NNP cord-010119-t1x9gknd 7756 27 Series Series NNP cord-010119-t1x9gknd 7756 28 4 4 NNP cord-010119-t1x9gknd 7756 29 and and CC cord-010119-t1x9gknd 7756 30 Series Series NNP cord-010119-t1x9gknd 7756 31 5 5 CD cord-010119-t1x9gknd 7756 32 , , , cord-010119-t1x9gknd 7756 33 and and CC cord-010119-t1x9gknd 7756 34 ALBAclone albaclone NN cord-010119-t1x9gknd 7756 35 anti anti JJ cord-010119-t1x9gknd 7756 36 - - JJ cord-010119-t1x9gknd 7756 37 D d JJ cord-010119-t1x9gknd 7756 38 reagents reagent NNS cord-010119-t1x9gknd 7756 39 . . . cord-010119-t1x9gknd 7757 1 DNA DNA NNP cord-010119-t1x9gknd 7757 2 isolated isolate VBN cord-010119-t1x9gknd 7757 3 from from IN cord-010119-t1x9gknd 7757 4 WBCs wbc NNS cord-010119-t1x9gknd 7757 5 was be VBD cord-010119-t1x9gknd 7757 6 used use VBN cord-010119-t1x9gknd 7757 7 in in IN cord-010119-t1x9gknd 7757 8 manual manual JJ cord-010119-t1x9gknd 7757 9 RFLP RFLP NNP cord-010119-t1x9gknd 7757 10 and and CC cord-010119-t1x9gknd 7757 11 RHD RHD NNP cord-010119-t1x9gknd 7757 12 BeadChip BeadChip NNP cord-010119-t1x9gknd 7757 13 assay assay NN cord-010119-t1x9gknd 7757 14 ( ( -LRB- cord-010119-t1x9gknd 7757 15 Immucor Immucor NNP cord-010119-t1x9gknd 7757 16 , , , cord-010119-t1x9gknd 7757 17 BioArray BioArray NNP cord-010119-t1x9gknd 7757 18 ) ) -RRB- cord-010119-t1x9gknd 7757 19 and and CC cord-010119-t1x9gknd 7757 20 RHD RHD NNP cord-010119-t1x9gknd 7757 21 sequencing sequencing NN cord-010119-t1x9gknd 7757 22 . . . cord-010119-t1x9gknd 7758 1 Results/ Results/ . cord-010119-t1x9gknd 7759 1 Finding finding NN cord-010119-t1x9gknd 7759 2 : : : cord-010119-t1x9gknd 7760 1 RBC RBC NNP cord-010119-t1x9gknd 7760 2 reactivity reactivity NN cord-010119-t1x9gknd 7760 3 is be VBZ cord-010119-t1x9gknd 7760 4 summarized summarize VBN cord-010119-t1x9gknd 7760 5 in in IN cord-010119-t1x9gknd 7760 6 the the DT cord-010119-t1x9gknd 7760 7 Table table NN cord-010119-t1x9gknd 7760 8 . . . cord-010119-t1x9gknd 7761 1 DNA dna NN cord-010119-t1x9gknd 7761 2 testing testing NN cord-010119-t1x9gknd 7761 3 detected detect VBD cord-010119-t1x9gknd 7761 4 a a DT cord-010119-t1x9gknd 7761 5 hybrid hybrid JJ cord-010119-t1x9gknd 7761 6 rhesus rhesus NN cord-010119-t1x9gknd 7761 7 box box NN cord-010119-t1x9gknd 7761 8 associated associate VBN cord-010119-t1x9gknd 7761 9 with with IN cord-010119-t1x9gknd 7761 10 the the DT cord-010119-t1x9gknd 7761 11 RHD RHD NNP cord-010119-t1x9gknd 7761 12 gene gene NN cord-010119-t1x9gknd 7761 13 deletion deletion NN cord-010119-t1x9gknd 7761 14 , , , cord-010119-t1x9gknd 7761 15 indicating indicate VBG cord-010119-t1x9gknd 7761 16 the the DT cord-010119-t1x9gknd 7761 17 patient patient NN cord-010119-t1x9gknd 7761 18 was be VBD cord-010119-t1x9gknd 7761 19 hemizygous hemizygous JJ cord-010119-t1x9gknd 7761 20 for for IN cord-010119-t1x9gknd 7761 21 RHD RHD NNP cord-010119-t1x9gknd 7761 22 . . . cord-010119-t1x9gknd 7762 1 RFLP RFLP NNP cord-010119-t1x9gknd 7762 2 assay assay NN cord-010119-t1x9gknd 7762 3 and and CC cord-010119-t1x9gknd 7762 4 RHD RHD NNP cord-010119-t1x9gknd 7762 5 BeadChip BeadChip NNP cord-010119-t1x9gknd 7762 6 did do VBD cord-010119-t1x9gknd 7762 7 not not RB cord-010119-t1x9gknd 7762 8 identify identify VB cord-010119-t1x9gknd 7762 9 any any DT cord-010119-t1x9gknd 7762 10 changes change NNS cord-010119-t1x9gknd 7762 11 . . . cord-010119-t1x9gknd 7763 1 RHD RHD NNP cord-010119-t1x9gknd 7763 2 gene gene NN cord-010119-t1x9gknd 7763 3 sequencing sequencing NN cord-010119-t1x9gknd 7763 4 identified identify VBD cord-010119-t1x9gknd 7763 5 a a DT cord-010119-t1x9gknd 7763 6 new new JJ cord-010119-t1x9gknd 7763 7 c.463A c.463A NNP cord-010119-t1x9gknd 7764 1 > > XX cord-010119-t1x9gknd 7765 1 G g NN cord-010119-t1x9gknd 7765 2 change change NN cord-010119-t1x9gknd 7765 3 in in IN cord-010119-t1x9gknd 7765 4 exon exon NN cord-010119-t1x9gknd 7765 5 3 3 CD cord-010119-t1x9gknd 7765 6 encoding encode VBG cord-010119-t1x9gknd 7765 7 an an DT cord-010119-t1x9gknd 7765 8 amino amino NN cord-010119-t1x9gknd 7765 9 acid acid NN cord-010119-t1x9gknd 7765 10 change change NN cord-010119-t1x9gknd 7765 11 p. p. NN cord-010119-t1x9gknd 7766 1 Met155Val Met155Val NNP cord-010119-t1x9gknd 7766 2 . . . cord-010119-t1x9gknd 7767 1 The the DT cord-010119-t1x9gknd 7767 2 predicted predict VBN cord-010119-t1x9gknd 7767 3 location location NN cord-010119-t1x9gknd 7767 4 of of IN cord-010119-t1x9gknd 7767 5 this this DT cord-010119-t1x9gknd 7767 6 change change NN cord-010119-t1x9gknd 7767 7 is be VBZ cord-010119-t1x9gknd 7767 8 within within IN cord-010119-t1x9gknd 7767 9 the the DT cord-010119-t1x9gknd 7767 10 fourth fourth JJ cord-010119-t1x9gknd 7767 11 transmembrane transmembrane NN cord-010119-t1x9gknd 7767 12 segment segment NN cord-010119-t1x9gknd 7767 13 of of IN cord-010119-t1x9gknd 7767 14 the the DT cord-010119-t1x9gknd 7767 15 RhD RhD NNP cord-010119-t1x9gknd 7767 16 protein protein NNP cord-010119-t1x9gknd 7767 17 . . . cord-010119-t1x9gknd 7768 1 Conclusion conclusion NN cord-010119-t1x9gknd 7768 2 : : : cord-010119-t1x9gknd 7768 3 We -PRON- PRP cord-010119-t1x9gknd 7768 4 identified identify VBD cord-010119-t1x9gknd 7768 5 a a DT cord-010119-t1x9gknd 7768 6 novel novel JJ cord-010119-t1x9gknd 7768 7 RHD RHD NNP cord-010119-t1x9gknd 7768 8 allele allele NN cord-010119-t1x9gknd 7768 9 with with IN cord-010119-t1x9gknd 7768 10 c.463A c.463A NNP cord-010119-t1x9gknd 7769 1 > > XX cord-010119-t1x9gknd 7770 1 G G NNP cord-010119-t1x9gknd 7770 2 ( ( -LRB- cord-010119-t1x9gknd 7770 3 p. p. NN cord-010119-t1x9gknd 7771 1 Met155Val met155val LS cord-010119-t1x9gknd 7771 2 ) ) -RRB- cord-010119-t1x9gknd 7771 3 change change NN cord-010119-t1x9gknd 7771 4 in in IN cord-010119-t1x9gknd 7771 5 exon exon NN cord-010119-t1x9gknd 7771 6 3 3 CD cord-010119-t1x9gknd 7771 7 . . . cord-010119-t1x9gknd 7772 1 Several several JJ cord-010119-t1x9gknd 7772 2 SNPs snp NNS cord-010119-t1x9gknd 7772 3 , , , cord-010119-t1x9gknd 7772 4 deletions deletion NNS cord-010119-t1x9gknd 7772 5 , , , cord-010119-t1x9gknd 7772 6 and and CC cord-010119-t1x9gknd 7772 7 insertions insertion NNS cord-010119-t1x9gknd 7772 8 have have VBP cord-010119-t1x9gknd 7772 9 been be VBN cord-010119-t1x9gknd 7772 10 reported report VBN cord-010119-t1x9gknd 7772 11 with with IN cord-010119-t1x9gknd 7772 12 changes change NNS cord-010119-t1x9gknd 7772 13 in in IN cord-010119-t1x9gknd 7772 14 Exon Exon NNP cord-010119-t1x9gknd 7772 15 3 3 CD cord-010119-t1x9gknd 7772 16 . . . cord-010119-t1x9gknd 7773 1 Phenotypes phenotype NNS cord-010119-t1x9gknd 7773 2 of of IN cord-010119-t1x9gknd 7773 3 these these DT cord-010119-t1x9gknd 7773 4 genetic genetic JJ cord-010119-t1x9gknd 7773 5 variations variation NNS cord-010119-t1x9gknd 7773 6 result result VBP cord-010119-t1x9gknd 7773 7 in in IN cord-010119-t1x9gknd 7773 8 Rh Rh NNP cord-010119-t1x9gknd 7773 9 negative negative JJ cord-010119-t1x9gknd 7773 10 , , , cord-010119-t1x9gknd 7773 11 weak weak JJ cord-010119-t1x9gknd 7773 12 D d NN cord-010119-t1x9gknd 7773 13 types type NNS cord-010119-t1x9gknd 7773 14 , , , cord-010119-t1x9gknd 7773 15 and and CC cord-010119-t1x9gknd 7773 16 variant variant NN cord-010119-t1x9gknd 7773 17 D. D. NNP cord-010119-t1x9gknd 7774 1 Since since IN cord-010119-t1x9gknd 7774 2 this this DT cord-010119-t1x9gknd 7774 3 change change NN cord-010119-t1x9gknd 7774 4 has have VBZ cord-010119-t1x9gknd 7774 5 not not RB cord-010119-t1x9gknd 7774 6 been be VBN cord-010119-t1x9gknd 7774 7 previously previously RB cord-010119-t1x9gknd 7774 8 identified identify VBN cord-010119-t1x9gknd 7774 9 , , , cord-010119-t1x9gknd 7774 10 we -PRON- PRP cord-010119-t1x9gknd 7774 11 are be VBP cord-010119-t1x9gknd 7774 12 unable unable JJ cord-010119-t1x9gknd 7774 13 to to TO cord-010119-t1x9gknd 7774 14 determine determine VB cord-010119-t1x9gknd 7774 15 if if IN cord-010119-t1x9gknd 7774 16 this this DT cord-010119-t1x9gknd 7774 17 confers confer VBZ cord-010119-t1x9gknd 7774 18 a a DT cord-010119-t1x9gknd 7774 19 risk risk NN cord-010119-t1x9gknd 7774 20 of of IN cord-010119-t1x9gknd 7774 21 anti anti JJ cord-010119-t1x9gknd 7774 22 - - JJ cord-010119-t1x9gknd 7774 23 D d JJ cord-010119-t1x9gknd 7774 24 alloimmunization alloimmunization NN cord-010119-t1x9gknd 7774 25 , , , cord-010119-t1x9gknd 7774 26 but but CC cord-010119-t1x9gknd 7774 27 the the DT cord-010119-t1x9gknd 7774 28 RHD RHD NNP cord-010119-t1x9gknd 7774 29 c.463A c.463A NNP cord-010119-t1x9gknd 7775 1 > > XX cord-010119-t1x9gknd 7776 1 G G NNP cord-010119-t1x9gknd 7776 2 SNP SNP NNP cord-010119-t1x9gknd 7776 3 results result VBZ cord-010119-t1x9gknd 7776 4 in in IN cord-010119-t1x9gknd 7776 5 serologically serologically RB cord-010119-t1x9gknd 7776 6 weak weak JJ cord-010119-t1x9gknd 7776 7 phenotypic phenotypic JJ cord-010119-t1x9gknd 7776 8 expression expression NN cord-010119-t1x9gknd 7776 9 of of IN cord-010119-t1x9gknd 7776 10 D d NN cord-010119-t1x9gknd 7776 11 antigen antigen NN cord-010119-t1x9gknd 7776 12 when when WRB cord-010119-t1x9gknd 7776 13 tested test VBN cord-010119-t1x9gknd 7776 14 by by IN cord-010119-t1x9gknd 7776 15 microtiterwell microtiterwell JJ cord-010119-t1x9gknd 7776 16 agglutination agglutination NN cord-010119-t1x9gknd 7776 17 on on IN cord-010119-t1x9gknd 7776 18 the the DT cord-010119-t1x9gknd 7776 19 NEO NEO NNP cord-010119-t1x9gknd 7776 20 / / SYM cord-010119-t1x9gknd 7776 21 Echo Echo NNP cord-010119-t1x9gknd 7776 22 platforms platform NNS cord-010119-t1x9gknd 7776 23 . . . cord-010119-t1x9gknd 7777 1 In in IN cord-010119-t1x9gknd 7777 2 this this DT cord-010119-t1x9gknd 7777 3 case case NN cord-010119-t1x9gknd 7777 4 the the DT cord-010119-t1x9gknd 7777 5 combination combination NN cord-010119-t1x9gknd 7777 6 of of IN cord-010119-t1x9gknd 7777 7 microtiter microtiter NN cord-010119-t1x9gknd 7777 8 - - HYPH cord-010119-t1x9gknd 7777 9 well well JJ cord-010119-t1x9gknd 7777 10 agglutination agglutination NN cord-010119-t1x9gknd 7777 11 and and CC cord-010119-t1x9gknd 7777 12 DNA dna NN cord-010119-t1x9gknd 7777 13 sequencing sequencing NN cord-010119-t1x9gknd 7777 14 helped help VBD cord-010119-t1x9gknd 7777 15 identify identify VB cord-010119-t1x9gknd 7777 16 a a DT cord-010119-t1x9gknd 7777 17 new new JJ cord-010119-t1x9gknd 7777 18 allele allele NN cord-010119-t1x9gknd 7777 19 which which WDT cord-010119-t1x9gknd 7777 20 would would MD cord-010119-t1x9gknd 7777 21 be be VB cord-010119-t1x9gknd 7777 22 missed miss VBN cord-010119-t1x9gknd 7777 23 by by IN cord-010119-t1x9gknd 7777 24 standard standard JJ cord-010119-t1x9gknd 7777 25 tube tube NN cord-010119-t1x9gknd 7777 26 serologic serologic NN cord-010119-t1x9gknd 7777 27 testing testing NN cord-010119-t1x9gknd 7777 28 and and CC cord-010119-t1x9gknd 7777 29 the the DT cord-010119-t1x9gknd 7777 30 current current NN cord-010119-t1x9gknd 7777 31 commercially commercially RB cord-010119-t1x9gknd 7777 32 available available JJ cord-010119-t1x9gknd 7777 33 array array NN cord-010119-t1x9gknd 7777 34 assays assay NNS cord-010119-t1x9gknd 7777 35 . . . cord-010119-t1x9gknd 7778 1 Serologic Serologic NNP cord-010119-t1x9gknd 7778 2 and and CC cord-010119-t1x9gknd 7778 3 Molecular Molecular NNP cord-010119-t1x9gknd 7778 4 Detection Detection NNP cord-010119-t1x9gknd 7778 5 of of IN cord-010119-t1x9gknd 7778 6 an an DT cord-010119-t1x9gknd 7778 7 Antibody Antibody NNP cord-010119-t1x9gknd 7778 8 to to IN cord-010119-t1x9gknd 7778 9 a a DT cord-010119-t1x9gknd 7778 10 High High NNP cord-010119-t1x9gknd 7778 11 Incidence Incidence NNP cord-010119-t1x9gknd 7778 12 Antigen Antigen NNP cord-010119-t1x9gknd 7778 13 in in IN cord-010119-t1x9gknd 7778 14 Patient Patient NNP cord-010119-t1x9gknd 7778 15 with with IN cord-010119-t1x9gknd 7778 16 History history NN cord-010119-t1x9gknd 7778 17 of of IN cord-010119-t1x9gknd 7778 18 Chronic Chronic NNP cord-010119-t1x9gknd 7778 19 Transfusions Transfusions NNPS cord-010119-t1x9gknd 7778 20 Georgia Georgia NNP cord-010119-t1x9gknd 7778 21 Spanos Spanos NNP cord-010119-t1x9gknd 7779 1 * * NFP cord-010119-t1x9gknd 7779 2 1 1 CD cord-010119-t1x9gknd 7779 3 , , , cord-010119-t1x9gknd 7779 4 Juan Juan NNP cord-010119-t1x9gknd 7779 5 Merayo Merayo NNP cord-010119-t1x9gknd 7779 6 - - HYPH cord-010119-t1x9gknd 7779 7 Rodriguez Rodriguez NNP cord-010119-t1x9gknd 7779 8 2 2 CD cord-010119-t1x9gknd 7779 9 , , , cord-010119-t1x9gknd 7779 10 Christopher Christopher NNP cord-010119-t1x9gknd 7779 11 Lough Lough NNP cord-010119-t1x9gknd 7779 12 1 1 CD cord-010119-t1x9gknd 7779 13 and and CC cord-010119-t1x9gknd 7779 14 Nancy Nancy NNP cord-010119-t1x9gknd 7779 15 Eckert Eckert NNP cord-010119-t1x9gknd 7780 1 3 3 LS cord-010119-t1x9gknd 7780 2 . . . cord-010119-t1x9gknd 7780 3 1 1 CD cord-010119-t1x9gknd 7780 4 LifeSouth LifeSouth NNP cord-010119-t1x9gknd 7780 5 Community Community NNP cord-010119-t1x9gknd 7780 6 Blood Blood NNP cord-010119-t1x9gknd 7780 7 Centers Centers NNPS cord-010119-t1x9gknd 7780 8 , , , cord-010119-t1x9gknd 7780 9 2 2 CD cord-010119-t1x9gknd 7780 10 Life Life NNP cord-010119-t1x9gknd 7780 11 South South NNP cord-010119-t1x9gknd 7780 12 Community Community NNP cord-010119-t1x9gknd 7780 13 Blood Blood NNP cord-010119-t1x9gknd 7780 14 Centers Centers NNPS cord-010119-t1x9gknd 7780 15 , , , cord-010119-t1x9gknd 7780 16 3 3 CD cord-010119-t1x9gknd 7780 17 LifeSouth LifeSouth NNP cord-010119-t1x9gknd 7780 18 Community Community NNP cord-010119-t1x9gknd 7780 19 Blood Blood NNP cord-010119-t1x9gknd 7780 20 Center Center NNP cord-010119-t1x9gknd 7780 21 - - HYPH cord-010119-t1x9gknd 7780 22 Headquarters Headquarters NNP cord-010119-t1x9gknd 7780 23 Background Background NNP cord-010119-t1x9gknd 7780 24 / / SYM cord-010119-t1x9gknd 7780 25 Case Case NNP cord-010119-t1x9gknd 7780 26 Studies Studies NNPS cord-010119-t1x9gknd 7780 27 : : : cord-010119-t1x9gknd 7781 1 The the DT cord-010119-t1x9gknd 7781 2 Jo Jo NNP cord-010119-t1x9gknd 7781 3 a a DT cord-010119-t1x9gknd 7781 4 antigen antigen NN cord-010119-t1x9gknd 7781 5 is be VBZ cord-010119-t1x9gknd 7781 6 one one CD cord-010119-t1x9gknd 7781 7 of of IN cord-010119-t1x9gknd 7781 8 three three CD cord-010119-t1x9gknd 7781 9 high high JJ cord-010119-t1x9gknd 7781 10 incidence incidence NN cord-010119-t1x9gknd 7781 11 antigens antigen NNS cord-010119-t1x9gknd 7781 12 in in IN cord-010119-t1x9gknd 7781 13 the the DT cord-010119-t1x9gknd 7781 14 Dombrock Dombrock NNP cord-010119-t1x9gknd 7781 15 system system NN cord-010119-t1x9gknd 7781 16 . . . cord-010119-t1x9gknd 7782 1 The the DT cord-010119-t1x9gknd 7782 2 prevalence prevalence NN cord-010119-t1x9gknd 7782 3 of of IN cord-010119-t1x9gknd 7782 4 this this DT cord-010119-t1x9gknd 7782 5 antigen antigen NN cord-010119-t1x9gknd 7782 6 is be VBZ cord-010119-t1x9gknd 7782 7 100 100 CD cord-010119-t1x9gknd 7782 8 % % NN cord-010119-t1x9gknd 7782 9 in in IN cord-010119-t1x9gknd 7782 10 most most JJS cord-010119-t1x9gknd 7782 11 populations population NNS cord-010119-t1x9gknd 7782 12 and and CC cord-010119-t1x9gknd 7782 13 greater great JJR cord-010119-t1x9gknd 7782 14 than than IN cord-010119-t1x9gknd 7782 15 99 99 CD cord-010119-t1x9gknd 7782 16 % % NN cord-010119-t1x9gknd 7782 17 in in IN cord-010119-t1x9gknd 7782 18 the the DT cord-010119-t1x9gknd 7782 19 black black JJ cord-010119-t1x9gknd 7782 20 population population NN cord-010119-t1x9gknd 7782 21 . . . cord-010119-t1x9gknd 7783 1 The the DT cord-010119-t1x9gknd 7783 2 Jo Jo NNP cord-010119-t1x9gknd 7783 3 a a DT cord-010119-t1x9gknd 7783 4 antigen antigen NN cord-010119-t1x9gknd 7783 5 can can MD cord-010119-t1x9gknd 7783 6 be be VB cord-010119-t1x9gknd 7783 7 resistant resistant JJ cord-010119-t1x9gknd 7783 8 or or CC cord-010119-t1x9gknd 7783 9 enhanced enhance VBN cord-010119-t1x9gknd 7783 10 with with IN cord-010119-t1x9gknd 7783 11 enzyme enzyme NN cord-010119-t1x9gknd 7783 12 treatment treatment NN cord-010119-t1x9gknd 7783 13 ( ( -LRB- cord-010119-t1x9gknd 7783 14 ficin ficin NNS cord-010119-t1x9gknd 7783 15 / / SYM cord-010119-t1x9gknd 7783 16 papain papain NN cord-010119-t1x9gknd 7783 17 ) ) -RRB- cord-010119-t1x9gknd 7783 18 and and CC cord-010119-t1x9gknd 7783 19 typically typically RB cord-010119-t1x9gknd 7783 20 variable variable JJ cord-010119-t1x9gknd 7783 21 with with IN cord-010119-t1x9gknd 7783 22 Dithiothreitol Dithiothreitol NNP cord-010119-t1x9gknd 7783 23 ( ( -LRB- cord-010119-t1x9gknd 7783 24 DTT DTT NNP cord-010119-t1x9gknd 7783 25 ) ) -RRB- cord-010119-t1x9gknd 7783 26 , , , cord-010119-t1x9gknd 7783 27 W.A.R.M. W.A.R.M. NNP cord-010119-t1x9gknd 7783 28 TM TM NNP cord-010119-t1x9gknd 7783 29 ( ( -LRB- cord-010119-t1x9gknd 7783 30 Immucor Immucor NNP cord-010119-t1x9gknd 7783 31 ) ) -RRB- cord-010119-t1x9gknd 7783 32 and and CC cord-010119-t1x9gknd 7783 33 ZZAP zzap NN cord-010119-t1x9gknd 7783 34 treatment treatment NN cord-010119-t1x9gknd 7783 35 . . . cord-010119-t1x9gknd 7784 1 Anti Anti NNP cord-010119-t1x9gknd 7784 2 - - NNP cord-010119-t1x9gknd 7784 3 Jo Jo NNP cord-010119-t1x9gknd 7784 4 a a NNP cord-010119-t1x9gknd 7784 5 is be VBZ cord-010119-t1x9gknd 7784 6 an an DT cord-010119-t1x9gknd 7784 7 IgG igg NN cord-010119-t1x9gknd 7784 8 antibody antibody NN cord-010119-t1x9gknd 7784 9 that that WDT cord-010119-t1x9gknd 7784 10 demonstrates demonstrate VBZ cord-010119-t1x9gknd 7784 11 at at IN cord-010119-t1x9gknd 7784 12 AHG AHG NNP cord-010119-t1x9gknd 7784 13 phase phase NN cord-010119-t1x9gknd 7784 14 . . . cord-010119-t1x9gknd 7785 1 Hemolytic hemolytic JJ cord-010119-t1x9gknd 7785 2 transfusion transfusion NN cord-010119-t1x9gknd 7785 3 reactions reaction NNS cord-010119-t1x9gknd 7785 4 to to IN cord-010119-t1x9gknd 7785 5 the the DT cord-010119-t1x9gknd 7785 6 Jo Jo NNP cord-010119-t1x9gknd 7785 7 a a DT cord-010119-t1x9gknd 7785 8 antigen antigen NN cord-010119-t1x9gknd 7785 9 vary vary VBP cord-010119-t1x9gknd 7785 10 from from IN cord-010119-t1x9gknd 7785 11 none none NN cord-010119-t1x9gknd 7785 12 to to TO cord-010119-t1x9gknd 7785 13 moderate moderate JJ cord-010119-t1x9gknd 7785 14 / / SYM cord-010119-t1x9gknd 7785 15 severe severe JJ cord-010119-t1x9gknd 7785 16 . . . cord-010119-t1x9gknd 7786 1 Hemolytic hemolytic JJ cord-010119-t1x9gknd 7786 2 Disease Disease NNP cord-010119-t1x9gknd 7786 3 of of IN cord-010119-t1x9gknd 7786 4 the the DT cord-010119-t1x9gknd 7786 5 Fetus Fetus NNP cord-010119-t1x9gknd 7786 6 and and CC cord-010119-t1x9gknd 7786 7 Newborn Newborn NNP cord-010119-t1x9gknd 7786 8 ( ( -LRB- cord-010119-t1x9gknd 7786 9 HDFN HDFN NNP cord-010119-t1x9gknd 7786 10 ) ) -RRB- cord-010119-t1x9gknd 7786 11 has have VBZ cord-010119-t1x9gknd 7786 12 not not RB cord-010119-t1x9gknd 7786 13 been be VBN cord-010119-t1x9gknd 7786 14 observed observe VBN cord-010119-t1x9gknd 7786 15 with with IN cord-010119-t1x9gknd 7786 16 any any DT cord-010119-t1x9gknd 7786 17 antibody antibody NN cord-010119-t1x9gknd 7786 18 associated associate VBN cord-010119-t1x9gknd 7786 19 in in IN cord-010119-t1x9gknd 7786 20 the the DT cord-010119-t1x9gknd 7786 21 Dombrock Dombrock NNP cord-010119-t1x9gknd 7786 22 system system NN cord-010119-t1x9gknd 7786 23 . . . cord-010119-t1x9gknd 7787 1 There there EX cord-010119-t1x9gknd 7787 2 are be VBP cord-010119-t1x9gknd 7787 3 two two CD cord-010119-t1x9gknd 7787 4 common common JJ cord-010119-t1x9gknd 7787 5 phenotypes phenotype NNS cord-010119-t1x9gknd 7787 6 present present JJ cord-010119-t1x9gknd 7787 7 in in IN cord-010119-t1x9gknd 7787 8 the the DT cord-010119-t1x9gknd 7787 9 black black JJ cord-010119-t1x9gknd 7787 10 population population NN cord-010119-t1x9gknd 7787 11 : : : cord-010119-t1x9gknd 7787 12 Hy Hy NNP cord-010119-t1x9gknd 7787 13 negative/ negative/ NNP cord-010119-t1x9gknd 7787 14 Jo Jo NNP cord-010119-t1x9gknd 7787 15 a a DT cord-010119-t1x9gknd 7787 16 negative negative JJ cord-010119-t1x9gknd 7787 17 and and CC cord-010119-t1x9gknd 7787 18 Hy Hy NNP cord-010119-t1x9gknd 7787 19 weakly weakly RB cord-010119-t1x9gknd 7787 20 expressed express VBD cord-010119-t1x9gknd 7787 21 / / SYM cord-010119-t1x9gknd 7787 22 Jo Jo NNP cord-010119-t1x9gknd 7787 23 a a DT cord-010119-t1x9gknd 7787 24 negative negative NN cord-010119-t1x9gknd 7787 25 . . . cord-010119-t1x9gknd 7788 1 Study Study NNP cord-010119-t1x9gknd 7788 2 Design Design NNP cord-010119-t1x9gknd 7788 3 / / SYM cord-010119-t1x9gknd 7788 4 Methods method NNS cord-010119-t1x9gknd 7788 5 : : : cord-010119-t1x9gknd 7789 1 An an DT cord-010119-t1x9gknd 7789 2 antibody antibody NN cord-010119-t1x9gknd 7789 3 identification identification NN cord-010119-t1x9gknd 7789 4 and and CC cord-010119-t1x9gknd 7789 5 red red JJ cord-010119-t1x9gknd 7789 6 blood blood NN cord-010119-t1x9gknd 7789 7 cell cell NN cord-010119-t1x9gknd 7789 8 ( ( -LRB- cord-010119-t1x9gknd 7789 9 RBC RBC NNP cord-010119-t1x9gknd 7789 10 ) ) -RRB- cord-010119-t1x9gknd 7789 11 units unit NNS cord-010119-t1x9gknd 7789 12 were be VBD cord-010119-t1x9gknd 7789 13 requested request VBN cord-010119-t1x9gknd 7789 14 for for IN cord-010119-t1x9gknd 7789 15 an an DT cord-010119-t1x9gknd 7789 16 O o NN cord-010119-t1x9gknd 7789 17 positive positive JJ cord-010119-t1x9gknd 7789 18 , , , cord-010119-t1x9gknd 7789 19 57 57 CD cord-010119-t1x9gknd 7789 20 year year NN cord-010119-t1x9gknd 7789 21 old old JJ cord-010119-t1x9gknd 7789 22 , , , cord-010119-t1x9gknd 7789 23 African african JJ cord-010119-t1x9gknd 7789 24 - - HYPH cord-010119-t1x9gknd 7789 25 American american JJ cord-010119-t1x9gknd 7789 26 female female NN cord-010119-t1x9gknd 7789 27 with with IN cord-010119-t1x9gknd 7789 28 a a DT cord-010119-t1x9gknd 7789 29 history history NN cord-010119-t1x9gknd 7789 30 of of IN cord-010119-t1x9gknd 7789 31 sickle sickle NN cord-010119-t1x9gknd 7789 32 cell cell NN cord-010119-t1x9gknd 7789 33 disease disease NN cord-010119-t1x9gknd 7789 34 and and CC cord-010119-t1x9gknd 7789 35 no no DT cord-010119-t1x9gknd 7789 36 history history NN cord-010119-t1x9gknd 7789 37 of of IN cord-010119-t1x9gknd 7789 38 pregnancy pregnancy NN cord-010119-t1x9gknd 7789 39 . . . cord-010119-t1x9gknd 7790 1 The the DT cord-010119-t1x9gknd 7790 2 patient patient NN cord-010119-t1x9gknd 7790 3 was be VBD cord-010119-t1x9gknd 7790 4 not not RB cord-010119-t1x9gknd 7790 5 recently recently RB cord-010119-t1x9gknd 7790 6 transfused transfuse VBN cord-010119-t1x9gknd 7790 7 , , , cord-010119-t1x9gknd 7790 8 however however RB cord-010119-t1x9gknd 7790 9 , , , cord-010119-t1x9gknd 7790 10 had have VBD cord-010119-t1x9gknd 7790 11 a a DT cord-010119-t1x9gknd 7790 12 history history NN cord-010119-t1x9gknd 7790 13 of of IN cord-010119-t1x9gknd 7790 14 chronic chronic JJ cord-010119-t1x9gknd 7790 15 transfusions transfusion NNS cord-010119-t1x9gknd 7790 16 . . . cord-010119-t1x9gknd 7791 1 Last last JJ cord-010119-t1x9gknd 7791 2 reported reported JJ cord-010119-t1x9gknd 7791 3 transfusion transfusion NN cord-010119-t1x9gknd 7791 4 was be VBD cord-010119-t1x9gknd 7791 5 three three CD cord-010119-t1x9gknd 7791 6 years year NNS cord-010119-t1x9gknd 7791 7 prior prior RB cord-010119-t1x9gknd 7791 8 to to IN cord-010119-t1x9gknd 7791 9 the the DT cord-010119-t1x9gknd 7791 10 current current JJ cord-010119-t1x9gknd 7791 11 specimen specimen NN cord-010119-t1x9gknd 7791 12 . . . cord-010119-t1x9gknd 7792 1 There there EX cord-010119-t1x9gknd 7792 2 were be VBD cord-010119-t1x9gknd 7792 3 no no DT cord-010119-t1x9gknd 7792 4 known know VBN cord-010119-t1x9gknd 7792 5 RBC RBC NNP cord-010119-t1x9gknd 7792 6 antibodies antibody NNS cord-010119-t1x9gknd 7792 7 at at IN cord-010119-t1x9gknd 7792 8 the the DT cord-010119-t1x9gknd 7792 9 time time NN cord-010119-t1x9gknd 7792 10 of of IN cord-010119-t1x9gknd 7792 11 the the DT cord-010119-t1x9gknd 7792 12 request request NN cord-010119-t1x9gknd 7792 13 . . . cord-010119-t1x9gknd 7793 1 Facility facility NN cord-010119-t1x9gknd 7793 2 reports report VBZ cord-010119-t1x9gknd 7793 3 that that IN cord-010119-t1x9gknd 7793 4 the the DT cord-010119-t1x9gknd 7793 5 patient patient NN cord-010119-t1x9gknd 7793 6 's 's POS cord-010119-t1x9gknd 7793 7 hemoglobin(g hemoglobin(g NN cord-010119-t1x9gknd 7793 8 / / SYM cord-010119-t1x9gknd 7793 9 dL)/hematocrit(% dl)/hematocrit(% NN cord-010119-t1x9gknd 7793 10 ) ) -RRB- cord-010119-t1x9gknd 7793 11 ( ( -LRB- cord-010119-t1x9gknd 7793 12 Hgb Hgb NNP cord-010119-t1x9gknd 7793 13 / / SYM cord-010119-t1x9gknd 7793 14 Hct Hct NNP cord-010119-t1x9gknd 7793 15 ) ) -RRB- cord-010119-t1x9gknd 7793 16 is be VBZ cord-010119-t1x9gknd 7793 17 6.4/ 6.4/ CD cord-010119-t1x9gknd 7793 18 18.8 18.8 CD cord-010119-t1x9gknd 7793 19 and and CC cord-010119-t1x9gknd 7793 20 does do VBZ cord-010119-t1x9gknd 7793 21 not not RB cord-010119-t1x9gknd 7793 22 appear appear VB cord-010119-t1x9gknd 7793 23 to to TO cord-010119-t1x9gknd 7793 24 be be VB cord-010119-t1x9gknd 7793 25 in in IN cord-010119-t1x9gknd 7793 26 sickle sickle NN cord-010119-t1x9gknd 7793 27 cell cell NN cord-010119-t1x9gknd 7793 28 crisis crisis NN cord-010119-t1x9gknd 7793 29 . . . cord-010119-t1x9gknd 7794 1 A a DT cord-010119-t1x9gknd 7794 2 request request NN cord-010119-t1x9gknd 7794 3 for for IN cord-010119-t1x9gknd 7794 4 phenotypically phenotypically RB cord-010119-t1x9gknd 7794 5 matched match VBN cord-010119-t1x9gknd 7794 6 units unit NNS cord-010119-t1x9gknd 7794 7 , , , cord-010119-t1x9gknd 7794 8 as as IN cord-010119-t1x9gknd 7794 9 per per IN cord-010119-t1x9gknd 7794 10 hospital hospital NN cord-010119-t1x9gknd 7794 11 policy policy NN cord-010119-t1x9gknd 7794 12 , , , cord-010119-t1x9gknd 7794 13 for for IN cord-010119-t1x9gknd 7794 14 C C NNP cord-010119-t1x9gknd 7794 15 , , , cord-010119-t1x9gknd 7794 16 E E NNP cord-010119-t1x9gknd 7794 17 , , , cord-010119-t1x9gknd 7794 18 K K NNP cord-010119-t1x9gknd 7794 19 and and CC cord-010119-t1x9gknd 7794 20 S S NNP cord-010119-t1x9gknd 7794 21 was be VBD cord-010119-t1x9gknd 7794 22 received receive VBN cord-010119-t1x9gknd 7794 23 by by IN cord-010119-t1x9gknd 7794 24 our -PRON- PRP$ cord-010119-t1x9gknd 7794 25 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 7794 26 Reference Reference NNP cord-010119-t1x9gknd 7794 27 Laboratory Laboratory NNP cord-010119-t1x9gknd 7794 28 ( ( -LRB- cord-010119-t1x9gknd 7794 29 IRL IRL NNP cord-010119-t1x9gknd 7794 30 ) ) -RRB- cord-010119-t1x9gknd 7794 31 . . . cord-010119-t1x9gknd 7795 1 Results/ Results/ . cord-010119-t1x9gknd 7796 1 Findings finding NNS cord-010119-t1x9gknd 7796 2 : : : cord-010119-t1x9gknd 7797 1 Anti Anti NNP cord-010119-t1x9gknd 7797 2 - - NNP cord-010119-t1x9gknd 7797 3 Jo Jo NNP cord-010119-t1x9gknd 7797 4 a a NNP cord-010119-t1x9gknd 7797 5 was be VBD cord-010119-t1x9gknd 7797 6 detected detect VBN cord-010119-t1x9gknd 7797 7 in in IN cord-010119-t1x9gknd 7797 8 patient patient NN cord-010119-t1x9gknd 7797 9 plasma plasma NN cord-010119-t1x9gknd 7797 10 reacting react VBG cord-010119-t1x9gknd 7797 11 with with IN cord-010119-t1x9gknd 7797 12 LISS LISS NNP cord-010119-t1x9gknd 7797 13 and and CC cord-010119-t1x9gknd 7797 14 PeG PeG NNP cord-010119-t1x9gknd 7797 15 ( ( -LRB- cord-010119-t1x9gknd 7797 16 tube tube NN cord-010119-t1x9gknd 7797 17 method method NN cord-010119-t1x9gknd 7797 18 ) ) -RRB- cord-010119-t1x9gknd 7797 19 and and CC cord-010119-t1x9gknd 7797 20 manual manual JJ cord-010119-t1x9gknd 7797 21 Gel gel NN cord-010119-t1x9gknd 7797 22 - - HYPH cord-010119-t1x9gknd 7797 23 IAT IAT NNP cord-010119-t1x9gknd 7797 24 . . . cord-010119-t1x9gknd 7798 1 The the DT cord-010119-t1x9gknd 7798 2 antibody antibody NN cord-010119-t1x9gknd 7798 3 was be VBD cord-010119-t1x9gknd 7798 4 resistant resistant JJ cord-010119-t1x9gknd 7798 5 when when WRB cord-010119-t1x9gknd 7798 6 tested test VBN cord-010119-t1x9gknd 7798 7 with with IN cord-010119-t1x9gknd 7798 8 DTT DTT NNP cord-010119-t1x9gknd 7798 9 treated treat VBD cord-010119-t1x9gknd 7798 10 red red JJ cord-010119-t1x9gknd 7798 11 cells cell NNS cord-010119-t1x9gknd 7798 12 . . . cord-010119-t1x9gknd 7799 1 In in IN cord-010119-t1x9gknd 7799 2 - - HYPH cord-010119-t1x9gknd 7799 3 house house NN cord-010119-t1x9gknd 7799 4 frozen frozen NN cord-010119-t1x9gknd 7799 5 reagent reagent NN cord-010119-t1x9gknd 7799 6 RBCs rbc NNS cord-010119-t1x9gknd 7799 7 negative negative JJ cord-010119-t1x9gknd 7799 8 for for IN cord-010119-t1x9gknd 7799 9 the the DT cord-010119-t1x9gknd 7799 10 Jo Jo NNP cord-010119-t1x9gknd 7799 11 a a DT cord-010119-t1x9gknd 7799 12 antigen antigen NN cord-010119-t1x9gknd 7799 13 ( ( -LRB- cord-010119-t1x9gknd 7799 14 positive positive JJ cord-010119-t1x9gknd 7799 15 for for IN cord-010119-t1x9gknd 7799 16 Hy Hy NNP cord-010119-t1x9gknd 7799 17 ) ) -RRB- cord-010119-t1x9gknd 7800 1 were be VBD cord-010119-t1x9gknd 7800 2 used use VBN cord-010119-t1x9gknd 7800 3 to to TO cord-010119-t1x9gknd 7800 4 serologically serologically RB cord-010119-t1x9gknd 7800 5 prove prove VB cord-010119-t1x9gknd 7800 6 the the DT cord-010119-t1x9gknd 7800 7 presence presence NN cord-010119-t1x9gknd 7800 8 of of IN cord-010119-t1x9gknd 7800 9 the the DT cord-010119-t1x9gknd 7800 10 antibody antibody NN cord-010119-t1x9gknd 7800 11 to to IN cord-010119-t1x9gknd 7800 12 this this DT cord-010119-t1x9gknd 7800 13 high high JJ cord-010119-t1x9gknd 7800 14 incidence incidence NN cord-010119-t1x9gknd 7800 15 antigen antigen NN cord-010119-t1x9gknd 7800 16 . . . cord-010119-t1x9gknd 7801 1 An an DT cord-010119-t1x9gknd 7801 2 allogenic allogenic JJ cord-010119-t1x9gknd 7801 3 PeG peg NN cord-010119-t1x9gknd 7801 4 adsorption adsorption NN cord-010119-t1x9gknd 7801 5 was be VBD cord-010119-t1x9gknd 7801 6 performed perform VBN cord-010119-t1x9gknd 7801 7 to to TO cord-010119-t1x9gknd 7801 8 rule rule VB cord-010119-t1x9gknd 7801 9 out out RP cord-010119-t1x9gknd 7801 10 other other JJ cord-010119-t1x9gknd 7801 11 common common JJ cord-010119-t1x9gknd 7801 12 clinically clinically RB cord-010119-t1x9gknd 7801 13 significant significant JJ cord-010119-t1x9gknd 7801 14 antibodies antibody NNS cord-010119-t1x9gknd 7801 15 . . . cord-010119-t1x9gknd 7802 1 Anti Anti NNP cord-010119-t1x9gknd 7802 2 - - NNP cord-010119-t1x9gknd 7802 3 Kp Kp NNP cord-010119-t1x9gknd 7802 4 a a NNP cord-010119-t1x9gknd 7802 5 was be VBD cord-010119-t1x9gknd 7802 6 identified identify VBN cord-010119-t1x9gknd 7802 7 using use VBG cord-010119-t1x9gknd 7802 8 this this DT cord-010119-t1x9gknd 7802 9 adsorbed adsorb VBN cord-010119-t1x9gknd 7802 10 plasma plasma NN cord-010119-t1x9gknd 7802 11 . . . cord-010119-t1x9gknd 7803 1 Further further RB cord-010119-t1x9gknd 7803 2 testing testing NN cord-010119-t1x9gknd 7803 3 with with IN cord-010119-t1x9gknd 7803 4 molecular molecular JJ cord-010119-t1x9gknd 7803 5 genotyping genotyping NN cord-010119-t1x9gknd 7803 6 ( ( -LRB- cord-010119-t1x9gknd 7803 7 Grifols Grifols NNP cord-010119-t1x9gknd 7803 8 IdCore IdCore NNP cord-010119-t1x9gknd 7803 9 XT XT NNP cord-010119-t1x9gknd 7803 10 ) ) -RRB- cord-010119-t1x9gknd 7803 11 confirmed confirm VBD cord-010119-t1x9gknd 7803 12 the the DT cord-010119-t1x9gknd 7803 13 patient patient NN cord-010119-t1x9gknd 7803 14 's 's POS cord-010119-t1x9gknd 7803 15 genotyping genotyping NN cord-010119-t1x9gknd 7803 16 as as IN cord-010119-t1x9gknd 7803 17 antigen antigen NN cord-010119-t1x9gknd 7803 18 negative negative JJ cord-010119-t1x9gknd 7803 19 for for IN cord-010119-t1x9gknd 7803 20 the the DT cord-010119-t1x9gknd 7803 21 Jo Jo NNP cord-010119-t1x9gknd 7803 22 a a NNP cord-010119-t1x9gknd 7803 23 , , , cord-010119-t1x9gknd 7803 24 Kp Kp NNP cord-010119-t1x9gknd 7803 25 a a DT cord-010119-t1x9gknd 7803 26 and and CC cord-010119-t1x9gknd 7803 27 positive positive JJ cord-010119-t1x9gknd 7803 28 for for IN cord-010119-t1x9gknd 7803 29 Hy Hy NNP cord-010119-t1x9gknd 7803 30 . . . cord-010119-t1x9gknd 7804 1 Conclusion conclusion NN cord-010119-t1x9gknd 7804 2 : : : cord-010119-t1x9gknd 7805 1 Molecular molecular JJ cord-010119-t1x9gknd 7805 2 testing testing NN cord-010119-t1x9gknd 7805 3 is be VBZ cord-010119-t1x9gknd 7805 4 frequently frequently RB cord-010119-t1x9gknd 7805 5 performed perform VBN cord-010119-t1x9gknd 7805 6 on on IN cord-010119-t1x9gknd 7805 7 patients patient NNS cord-010119-t1x9gknd 7805 8 and and CC cord-010119-t1x9gknd 7805 9 retained retain VBN cord-010119-t1x9gknd 7805 10 donor donor NN cord-010119-t1x9gknd 7805 11 samples sample NNS cord-010119-t1x9gknd 7805 12 from from IN cord-010119-t1x9gknd 7805 13 our -PRON- PRP$ cord-010119-t1x9gknd 7805 14 local local JJ cord-010119-t1x9gknd 7805 15 community community NN cord-010119-t1x9gknd 7805 16 donor donor NN cord-010119-t1x9gknd 7805 17 pool pool NN cord-010119-t1x9gknd 7805 18 throughout throughout IN cord-010119-t1x9gknd 7805 19 Florida Florida NNP cord-010119-t1x9gknd 7805 20 , , , cord-010119-t1x9gknd 7805 21 Georgia Georgia NNP cord-010119-t1x9gknd 7805 22 and and CC cord-010119-t1x9gknd 7805 23 Alabama Alabama NNP cord-010119-t1x9gknd 7805 24 . . . cord-010119-t1x9gknd 7806 1 Staff staff NN cord-010119-t1x9gknd 7806 2 is be VBZ cord-010119-t1x9gknd 7806 3 able able JJ cord-010119-t1x9gknd 7806 4 to to TO cord-010119-t1x9gknd 7806 5 search search VB cord-010119-t1x9gknd 7806 6 our -PRON- PRP$ cord-010119-t1x9gknd 7806 7 database database NN cord-010119-t1x9gknd 7806 8 for for IN cord-010119-t1x9gknd 7806 9 any any DT cord-010119-t1x9gknd 7806 10 combination combination NN cord-010119-t1x9gknd 7806 11 of of IN cord-010119-t1x9gknd 7806 12 antigen antigen NN cord-010119-t1x9gknd 7806 13 negative negative JJ cord-010119-t1x9gknd 7806 14 phenotypes phenotype NNS cord-010119-t1x9gknd 7806 15 using use VBG cord-010119-t1x9gknd 7806 16 the the DT cord-010119-t1x9gknd 7806 17 internal internal JJ cord-010119-t1x9gknd 7806 18 510(k 510(k CD cord-010119-t1x9gknd 7806 19 ) ) -RRB- cord-010119-t1x9gknd 7806 20 Blood Blood NNP cord-010119-t1x9gknd 7806 21 Establishment Establishment NNP cord-010119-t1x9gknd 7806 22 Computer Computer NNP cord-010119-t1x9gknd 7806 23 Software Software NNP cord-010119-t1x9gknd 7806 24 ( ( -LRB- cord-010119-t1x9gknd 7806 25 BECS BECS NNP cord-010119-t1x9gknd 7806 26 ) ) -RRB- cord-010119-t1x9gknd 7807 1 Integrated Integrated NNP cord-010119-t1x9gknd 7807 2 Blood Blood NNP cord-010119-t1x9gknd 7807 3 Bank Bank NNP cord-010119-t1x9gknd 7807 4 Information Information NNP cord-010119-t1x9gknd 7807 5 System System NNP cord-010119-t1x9gknd 7807 6 ( ( -LRB- cord-010119-t1x9gknd 7807 7 IBBIS IBBIS NNP cord-010119-t1x9gknd 7807 8 ) ) -RRB- cord-010119-t1x9gknd 7807 9 . . . cord-010119-t1x9gknd 7808 1 This this DT cord-010119-t1x9gknd 7808 2 enabled enable VBD cord-010119-t1x9gknd 7808 3 us -PRON- PRP cord-010119-t1x9gknd 7808 4 to to TO cord-010119-t1x9gknd 7808 5 locate locate VB cord-010119-t1x9gknd 7808 6 one one CD cord-010119-t1x9gknd 7808 7 refrigerated refrigerate VBN cord-010119-t1x9gknd 7808 8 and and CC cord-010119-t1x9gknd 7808 9 three three CD cord-010119-t1x9gknd 7808 10 cryogenically cryogenically RB cord-010119-t1x9gknd 7808 11 preserved preserve VBN cord-010119-t1x9gknd 7808 12 Jo Jo NNP cord-010119-t1x9gknd 7808 13 a a DT cord-010119-t1x9gknd 7808 14 negative negative JJ cord-010119-t1x9gknd 7808 15 RBC RBC NNP cord-010119-t1x9gknd 7808 16 units unit NNS cord-010119-t1x9gknd 7808 17 . . . cord-010119-t1x9gknd 7809 1 We -PRON- PRP cord-010119-t1x9gknd 7809 2 found find VBD cord-010119-t1x9gknd 7809 3 251 251 CD cord-010119-t1x9gknd 7809 4 eligible eligible JJ cord-010119-t1x9gknd 7809 5 blood blood NN cord-010119-t1x9gknd 7809 6 donors donor NNS cord-010119-t1x9gknd 7809 7 that that WDT cord-010119-t1x9gknd 7809 8 could could MD cord-010119-t1x9gknd 7809 9 be be VB cord-010119-t1x9gknd 7809 10 recruited recruit VBN cord-010119-t1x9gknd 7809 11 via via IN cord-010119-t1x9gknd 7809 12 an an DT cord-010119-t1x9gknd 7809 13 automatically automatically RB cord-010119-t1x9gknd 7809 14 generated generate VBN cord-010119-t1x9gknd 7809 15 call call NN cord-010119-t1x9gknd 7809 16 list list NN cord-010119-t1x9gknd 7809 17 . . . cord-010119-t1x9gknd 7810 1 The the DT cord-010119-t1x9gknd 7810 2 request request NN cord-010119-t1x9gknd 7810 3 for for IN cord-010119-t1x9gknd 7810 4 RBCs rbc NNS cord-010119-t1x9gknd 7810 5 was be VBD cord-010119-t1x9gknd 7810 6 cancelled cancel VBN cord-010119-t1x9gknd 7810 7 . . . cord-010119-t1x9gknd 7811 1 Patient Patient NNP cord-010119-t1x9gknd 7811 2 's 's POS cord-010119-t1x9gknd 7811 3 clinical clinical JJ cord-010119-t1x9gknd 7811 4 symptoms symptom NNS cord-010119-t1x9gknd 7811 5 improved improve VBN cord-010119-t1x9gknd 7811 6 without without IN cord-010119-t1x9gknd 7811 7 transfusion transfusion NN cord-010119-t1x9gknd 7811 8 and and CC cord-010119-t1x9gknd 7811 9 repeat repeat VB cord-010119-t1x9gknd 7811 10 Hgb Hgb NNP cord-010119-t1x9gknd 7811 11 / / SYM cord-010119-t1x9gknd 7811 12 Hct Hct NNP cord-010119-t1x9gknd 7811 13 increased increase VBD cord-010119-t1x9gknd 7811 14 to to IN cord-010119-t1x9gknd 7811 15 7.1/21 7.1/21 CD cord-010119-t1x9gknd 7811 16 . . . cord-010119-t1x9gknd 7812 1 The the DT cord-010119-t1x9gknd 7812 2 patient patient NN cord-010119-t1x9gknd 7812 3 's 's POS cord-010119-t1x9gknd 7812 4 sibling sibling NN cord-010119-t1x9gknd 7812 5 is be VBZ cord-010119-t1x9gknd 7812 6 historically historically RB cord-010119-t1x9gknd 7812 7 negative negative JJ cord-010119-t1x9gknd 7812 8 for for IN cord-010119-t1x9gknd 7812 9 the the DT cord-010119-t1x9gknd 7812 10 Jo Jo NNP cord-010119-t1x9gknd 7812 11 a a DT cord-010119-t1x9gknd 7812 12 antigen antigen NN cord-010119-t1x9gknd 7812 13 and and CC cord-010119-t1x9gknd 7812 14 should should MD cord-010119-t1x9gknd 7812 15 future future JJ cord-010119-t1x9gknd 7812 16 transfusions transfusion NNS cord-010119-t1x9gknd 7812 17 be be VB cord-010119-t1x9gknd 7812 18 required require VBN cord-010119-t1x9gknd 7812 19 , , , cord-010119-t1x9gknd 7812 20 it -PRON- PRP cord-010119-t1x9gknd 7812 21 was be VBD cord-010119-t1x9gknd 7812 22 recommended recommend VBN cord-010119-t1x9gknd 7812 23 that that IN cord-010119-t1x9gknd 7812 24 a a DT cord-010119-t1x9gknd 7812 25 directed direct VBN cord-010119-t1x9gknd 7812 26 donation donation NN cord-010119-t1x9gknd 7812 27 be be VB cord-010119-t1x9gknd 7812 28 made make VBN cord-010119-t1x9gknd 7812 29 on on IN cord-010119-t1x9gknd 7812 30 the the DT cord-010119-t1x9gknd 7812 31 patient patient NN cord-010119-t1x9gknd 7812 32 's 's POS cord-010119-t1x9gknd 7812 33 behalf behalf NN cord-010119-t1x9gknd 7812 34 . . . cord-010119-t1x9gknd 7813 1 In in IN cord-010119-t1x9gknd 7813 2 order order NN cord-010119-t1x9gknd 7813 3 to to TO cord-010119-t1x9gknd 7813 4 continue continue VB cord-010119-t1x9gknd 7813 5 having have VBG cord-010119-t1x9gknd 7813 6 blood blood NN cord-010119-t1x9gknd 7813 7 components component NNS cord-010119-t1x9gknd 7813 8 available available JJ cord-010119-t1x9gknd 7813 9 to to TO cord-010119-t1x9gknd 7813 10 meet meet VB cord-010119-t1x9gknd 7813 11 all all PDT cord-010119-t1x9gknd 7813 12 our -PRON- PRP$ cord-010119-t1x9gknd 7813 13 patient patient NN cord-010119-t1x9gknd 7813 14 's 's POS cord-010119-t1x9gknd 7813 15 needs need NNS cord-010119-t1x9gknd 7813 16 , , , cord-010119-t1x9gknd 7813 17 IRL IRL NNP cord-010119-t1x9gknd 7813 18 staff staff NN cord-010119-t1x9gknd 7813 19 is be VBZ cord-010119-t1x9gknd 7813 20 consistently consistently RB cord-010119-t1x9gknd 7813 21 screening screen VBG cord-010119-t1x9gknd 7813 22 and and CC cord-010119-t1x9gknd 7813 23 searching search VBG cord-010119-t1x9gknd 7813 24 our -PRON- PRP$ cord-010119-t1x9gknd 7813 25 inventory inventory NN cord-010119-t1x9gknd 7813 26 for for IN cord-010119-t1x9gknd 7813 27 blood blood NN cord-010119-t1x9gknd 7813 28 components component NNS cord-010119-t1x9gknd 7813 29 that that WDT cord-010119-t1x9gknd 7813 30 are be VBP cord-010119-t1x9gknd 7813 31 negative negative JJ cord-010119-t1x9gknd 7813 32 for for IN cord-010119-t1x9gknd 7813 33 rare rare JJ cord-010119-t1x9gknd 7813 34 antigens antigen NNS cord-010119-t1x9gknd 7813 35 to to TO cord-010119-t1x9gknd 7813 36 retain retain VB cord-010119-t1x9gknd 7813 37 for for IN cord-010119-t1x9gknd 7813 38 patients patient NNS cord-010119-t1x9gknd 7813 39 needing need VBG cord-010119-t1x9gknd 7813 40 antigen antigen NN cord-010119-t1x9gknd 7813 41 negative negative JJ cord-010119-t1x9gknd 7813 42 units unit NNS cord-010119-t1x9gknd 7813 43 in in IN cord-010119-t1x9gknd 7813 44 a a DT cord-010119-t1x9gknd 7813 45 timely timely JJ cord-010119-t1x9gknd 7813 46 fashion fashion NN cord-010119-t1x9gknd 7813 47 . . . cord-010119-t1x9gknd 7814 1 RBCs rbc NNS cord-010119-t1x9gknd 7814 2 of of IN cord-010119-t1x9gknd 7814 3 two two CD cord-010119-t1x9gknd 7814 4 females female NNS cord-010119-t1x9gknd 7814 5 whose whose WP$ cord-010119-t1x9gknd 7814 6 samples sample NNS cord-010119-t1x9gknd 7814 7 were be VBD cord-010119-t1x9gknd 7814 8 referred refer VBN cord-010119-t1x9gknd 7814 9 for for IN cord-010119-t1x9gknd 7814 10 RHD RHD NNP cord-010119-t1x9gknd 7814 11 genotyping genotyping NN cord-010119-t1x9gknd 7814 12 with with IN cord-010119-t1x9gknd 7814 13 previously previously RB cord-010119-t1x9gknd 7814 14 reported report VBN cord-010119-t1x9gknd 7814 15 alleles allele NNS cord-010119-t1x9gknd 7814 16 for for IN cord-010119-t1x9gknd 7814 17 which which WDT cord-010119-t1x9gknd 7814 18 serologic serologic NNP cord-010119-t1x9gknd 7814 19 reactivity reactivity NN cord-010119-t1x9gknd 7814 20 had have VBD cord-010119-t1x9gknd 7814 21 never never RB cord-010119-t1x9gknd 7814 22 been be VBN cord-010119-t1x9gknd 7814 23 investigated investigate VBN cord-010119-t1x9gknd 7814 24 . . . cord-010119-t1x9gknd 7815 1 Study Study NNP cord-010119-t1x9gknd 7815 2 Design Design NNP cord-010119-t1x9gknd 7815 3 / / SYM cord-010119-t1x9gknd 7815 4 Method method NN cord-010119-t1x9gknd 7815 5 : : : cord-010119-t1x9gknd 7815 6 Serologic Serologic NNP cord-010119-t1x9gknd 7815 7 testing testing NN cord-010119-t1x9gknd 7815 8 was be VBD cord-010119-t1x9gknd 7815 9 performed perform VBN cord-010119-t1x9gknd 7815 10 by by IN cord-010119-t1x9gknd 7815 11 automated automated JJ cord-010119-t1x9gknd 7815 12 analyzer analyzer NN cord-010119-t1x9gknd 7815 13 , , , cord-010119-t1x9gknd 7815 14 Galileo Galileo NNP cord-010119-t1x9gknd 7815 15 Echo Echo NNP cord-010119-t1x9gknd 7815 16 and and CC cord-010119-t1x9gknd 7815 17 NEO NEO NNP cord-010119-t1x9gknd 7815 18 ( ( -LRB- cord-010119-t1x9gknd 7815 19 Immucor Immucor NNP cord-010119-t1x9gknd 7815 20 , , , cord-010119-t1x9gknd 7815 21 Norcross Norcross NNP cord-010119-t1x9gknd 7815 22 , , , cord-010119-t1x9gknd 7815 23 GA GA NNP cord-010119-t1x9gknd 7815 24 ) ) -RRB- cord-010119-t1x9gknd 7815 25 , , , cord-010119-t1x9gknd 7815 26 and and CC cord-010119-t1x9gknd 7815 27 by by IN cord-010119-t1x9gknd 7815 28 standard standard JJ cord-010119-t1x9gknd 7815 29 tube tube NN cord-010119-t1x9gknd 7815 30 testing testing NN cord-010119-t1x9gknd 7815 31 with with IN cord-010119-t1x9gknd 7815 32 licensed licensed JJ cord-010119-t1x9gknd 7815 33 anti anti JJ cord-010119-t1x9gknd 7815 34 - - JJ cord-010119-t1x9gknd 7815 35 D d JJ cord-010119-t1x9gknd 7815 36 reagents reagent NNS cord-010119-t1x9gknd 7815 37 and and CC cord-010119-t1x9gknd 7815 38 the the DT cord-010119-t1x9gknd 7815 39 ALBAclone ALBAclone NNP cord-010119-t1x9gknd 7815 40 advanced advance VBD cord-010119-t1x9gknd 7815 41 partial partial JJ cord-010119-t1x9gknd 7815 42 RhD rhd NN cord-010119-t1x9gknd 7815 43 typing typing NN cord-010119-t1x9gknd 7815 44 kit kit NN cord-010119-t1x9gknd 7815 45 . . . cord-010119-t1x9gknd 7816 1 Genomic genomic JJ cord-010119-t1x9gknd 7816 2 DNA dna NN cord-010119-t1x9gknd 7816 3 isolated isolate VBN cord-010119-t1x9gknd 7816 4 from from IN cord-010119-t1x9gknd 7816 5 WBCs wbc NNS cord-010119-t1x9gknd 7816 6 was be VBD cord-010119-t1x9gknd 7816 7 used use VBN cord-010119-t1x9gknd 7816 8 for for IN cord-010119-t1x9gknd 7816 9 Immucor Immucor NNP cord-010119-t1x9gknd 7816 10 RHD RHD NNP cord-010119-t1x9gknd 7816 11 BeadChip BeadChip NNP cord-010119-t1x9gknd 7816 12 assay assay NN cord-010119-t1x9gknd 7816 13 , , , cord-010119-t1x9gknd 7816 14 PCR PCR NNP cord-010119-t1x9gknd 7816 15 - - HYPH cord-010119-t1x9gknd 7816 16 RFLP RFLP NNP cord-010119-t1x9gknd 7816 17 , , , cord-010119-t1x9gknd 7816 18 and and CC cord-010119-t1x9gknd 7816 19 RHD RHD NNP cord-010119-t1x9gknd 7816 20 sequencing sequencing NN cord-010119-t1x9gknd 7816 21 . . . cord-010119-t1x9gknd 7817 1 Results/ Results/ . cord-010119-t1x9gknd 7818 1 Finding finding NN cord-010119-t1x9gknd 7818 2 : : : cord-010119-t1x9gknd 7819 1 Patient patient NN cord-010119-t1x9gknd 7819 2 1 1 CD cord-010119-t1x9gknd 7819 3 was be VBD cord-010119-t1x9gknd 7819 4 a a DT cord-010119-t1x9gknd 7819 5 29 29 CD cord-010119-t1x9gknd 7819 6 yo yo NNP cord-010119-t1x9gknd 7819 7 female female NN cord-010119-t1x9gknd 7819 8 , , , cord-010119-t1x9gknd 7819 9 C2E2c1e1 c2e2c1e1 RB cord-010119-t1x9gknd 7819 10 , , , cord-010119-t1x9gknd 7819 11 whose whose WP$ cord-010119-t1x9gknd 7819 12 RBCs rbc NNS cord-010119-t1x9gknd 7819 13 reacted react VBD cord-010119-t1x9gknd 7819 14 11 11 CD cord-010119-t1x9gknd 7819 15 by by IN cord-010119-t1x9gknd 7819 16 ECHO ECHO NNP cord-010119-t1x9gknd 7819 17 and and CC cord-010119-t1x9gknd 7819 18 31 31 CD cord-010119-t1x9gknd 7819 19 by by IN cord-010119-t1x9gknd 7819 20 NEO NEO NNP cord-010119-t1x9gknd 7819 21 with with IN cord-010119-t1x9gknd 7819 22 anti anti JJ cord-010119-t1x9gknd 7819 23 - - JJ cord-010119-t1x9gknd 7819 24 D4 d4 NN cord-010119-t1x9gknd 7819 25 , , , cord-010119-t1x9gknd 7819 26 and and CC cord-010119-t1x9gknd 7819 27 ' ' '' cord-010119-t1x9gknd 7819 28 ? ? . cord-010119-t1x9gknd 7819 29 ' ' '' cord-010119-t1x9gknd 7820 1 with with IN cord-010119-t1x9gknd 7820 2 anti anti JJ cord-010119-t1x9gknd 7820 3 - - JJ cord-010119-t1x9gknd 7820 4 D5 d5 NN cord-010119-t1x9gknd 7820 5 . . . cord-010119-t1x9gknd 7821 1 Testing test VBG cord-010119-t1x9gknd 7821 2 with with IN cord-010119-t1x9gknd 7821 3 D4 d4 NN cord-010119-t1x9gknd 7821 4 and and CC cord-010119-t1x9gknd 7821 5 D5 d5 NN cord-010119-t1x9gknd 7821 6 by by IN cord-010119-t1x9gknd 7821 7 tube tube NN cord-010119-t1x9gknd 7821 8 gave give VBD cord-010119-t1x9gknd 7821 9 21 21 CD cord-010119-t1x9gknd 7821 10 and and CC cord-010119-t1x9gknd 7821 11 11 11 CD cord-010119-t1x9gknd 7821 12 w w NN cord-010119-t1x9gknd 7821 13 on on IN cord-010119-t1x9gknd 7821 14 initial initial JJ cord-010119-t1x9gknd 7821 15 spin spin NN cord-010119-t1x9gknd 7821 16 ( ( -LRB- cord-010119-t1x9gknd 7821 17 IS be VBZ cord-010119-t1x9gknd 7821 18 ) ) -RRB- cord-010119-t1x9gknd 7821 19 respectively respectively RB cord-010119-t1x9gknd 7821 20 and and CC cord-010119-t1x9gknd 7821 21 41 41 CD cord-010119-t1x9gknd 7821 22 by by IN cord-010119-t1x9gknd 7821 23 indirect indirect JJ cord-010119-t1x9gknd 7821 24 antiglobulin antiglobulin NN cord-010119-t1x9gknd 7821 25 test test NN cord-010119-t1x9gknd 7821 26 ( ( -LRB- cord-010119-t1x9gknd 7821 27 IAT IAT NNP cord-010119-t1x9gknd 7821 28 ) ) -RRB- cord-010119-t1x9gknd 7821 29 . . . cord-010119-t1x9gknd 7822 1 RBCs rbc NNS cord-010119-t1x9gknd 7822 2 were be VBD cord-010119-t1x9gknd 7822 3 non non JJ cord-010119-t1x9gknd 7822 4 - - JJ cord-010119-t1x9gknd 7822 5 reactive reactive JJ cord-010119-t1x9gknd 7822 6 at at IN cord-010119-t1x9gknd 7822 7 IS be VBZ cord-010119-t1x9gknd 7822 8 with with IN cord-010119-t1x9gknd 7822 9 Ortho Ortho NNP cord-010119-t1x9gknd 7822 10 BioClone BioClone NNP cord-010119-t1x9gknd 7822 11 and and CC cord-010119-t1x9gknd 7822 12 BioRad BioRad NNP cord-010119-t1x9gknd 7822 13 Seraclone Seraclone NNP cord-010119-t1x9gknd 7822 14 , , , cord-010119-t1x9gknd 7822 15 and and CC cord-010119-t1x9gknd 7823 1 1 1 CD cord-010119-t1x9gknd 7823 2 w w NN cord-010119-t1x9gknd 7823 3 with with IN cord-010119-t1x9gknd 7823 4 Immucor Immucor NNP cord-010119-t1x9gknd 7823 5 Gammaclone Gammaclone NNP cord-010119-t1x9gknd 7823 6 anti anti JJ cord-010119-t1x9gknd 7823 7 - - JJ cord-010119-t1x9gknd 7823 8 D d JJ cord-010119-t1x9gknd 7823 9 , , , cord-010119-t1x9gknd 7823 10 and and CC cord-010119-t1x9gknd 7823 11 all all DT cord-010119-t1x9gknd 7823 12 were be VBD cord-010119-t1x9gknd 7823 13 21 21 CD cord-010119-t1x9gknd 7823 14 at at IN cord-010119-t1x9gknd 7823 15 IAT IAT NNP cord-010119-t1x9gknd 7823 16 . . . cord-010119-t1x9gknd 7824 1 RBCs rbc NNS cord-010119-t1x9gknd 7824 2 did do VBD cord-010119-t1x9gknd 7824 3 not not RB cord-010119-t1x9gknd 7824 4 react react VB cord-010119-t1x9gknd 7824 5 with with IN cord-010119-t1x9gknd 7824 6 two two CD cord-010119-t1x9gknd 7824 7 ( ( -LRB- cord-010119-t1x9gknd 7824 8 LHM LHM NNP cord-010119-t1x9gknd 7824 9 174/102 174/102 NNP cord-010119-t1x9gknd 7824 10 & & CC cord-010119-t1x9gknd 7824 11 57/17 57/17 CD cord-010119-t1x9gknd 7824 12 ) ) -RRB- cord-010119-t1x9gknd 7824 13 of of IN cord-010119-t1x9gknd 7824 14 12 12 CD cord-010119-t1x9gknd 7824 15 anti anti JJ cord-010119-t1x9gknd 7824 16 - - JJ cord-010119-t1x9gknd 7824 17 D d JJ cord-010119-t1x9gknd 7824 18 in in IN cord-010119-t1x9gknd 7824 19 the the DT cord-010119-t1x9gknd 7824 20 Alba Alba NNP cord-010119-t1x9gknd 7824 21 partial partial JJ cord-010119-t1x9gknd 7824 22 D d NN cord-010119-t1x9gknd 7824 23 kit kit NN cord-010119-t1x9gknd 7824 24 . . . cord-010119-t1x9gknd 7825 1 This this DT cord-010119-t1x9gknd 7825 2 pattern pattern NN cord-010119-t1x9gknd 7825 3 did do VBD cord-010119-t1x9gknd 7825 4 not not RB cord-010119-t1x9gknd 7825 5 match match VB cord-010119-t1x9gknd 7825 6 any any DT cord-010119-t1x9gknd 7825 7 partial partial JJ cord-010119-t1x9gknd 7825 8 D d NN cord-010119-t1x9gknd 7825 9 identified identify VBN cord-010119-t1x9gknd 7825 10 by by IN cord-010119-t1x9gknd 7825 11 these these DT cord-010119-t1x9gknd 7825 12 clones clone NNS cord-010119-t1x9gknd 7825 13 . . . cord-010119-t1x9gknd 7826 1 RHD RHD NNP cord-010119-t1x9gknd 7826 2 BeadChip BeadChip NNP cord-010119-t1x9gknd 7826 3 detected detect VBD cord-010119-t1x9gknd 7826 4 an an DT cord-010119-t1x9gknd 7826 5 inactive inactive JJ cord-010119-t1x9gknd 7826 6 RHD RHD NNP cord-010119-t1x9gknd 7826 7 pseudogene pseudogene NN cord-010119-t1x9gknd 7826 8 in in IN cord-010119-t1x9gknd 7826 9 trans trans NNP cord-010119-t1x9gknd 7826 10 to to IN cord-010119-t1x9gknd 7826 11 RHD RHD NNP cord-010119-t1x9gknd 7826 12 . . . cord-010119-t1x9gknd 7827 1 Gene gene NN cord-010119-t1x9gknd 7827 2 sequencing sequencing NN cord-010119-t1x9gknd 7827 3 confirmed confirm VBD cord-010119-t1x9gknd 7827 4 the the DT cord-010119-t1x9gknd 7827 5 presence presence NN cord-010119-t1x9gknd 7827 6 of of IN cord-010119-t1x9gknd 7827 7 the the DT cord-010119-t1x9gknd 7827 8 pseudogene pseudogene NN cord-010119-t1x9gknd 7827 9 , , , cord-010119-t1x9gknd 7827 10 but but CC cord-010119-t1x9gknd 7827 11 RHD RHD NNP cord-010119-t1x9gknd 7827 12 had have VBD cord-010119-t1x9gknd 7827 13 a a DT cord-010119-t1x9gknd 7827 14 c.780C c.780C NNP cord-010119-t1x9gknd 7828 1 > > XX cord-010119-t1x9gknd 7829 1 A a DT cord-010119-t1x9gknd 7829 2 change change NN cord-010119-t1x9gknd 7829 3 encoding encoding NN cord-010119-t1x9gknd 7829 4 p. p. NN cord-010119-t1x9gknd 7830 1 His260Gln his260gln UH cord-010119-t1x9gknd 7830 2 . . . cord-010119-t1x9gknd 7831 1 Patient Patient NNP cord-010119-t1x9gknd 7831 2 2 2 CD cord-010119-t1x9gknd 7831 3 was be VBD cord-010119-t1x9gknd 7831 4 a a DT cord-010119-t1x9gknd 7831 5 20 20 CD cord-010119-t1x9gknd 7831 6 yo yo UH cord-010119-t1x9gknd 7831 7 pregnant pregnant JJ cord-010119-t1x9gknd 7831 8 female female NN cord-010119-t1x9gknd 7831 9 , , , cord-010119-t1x9gknd 7831 10 C2E2c1e1 c2e2c1e1 RB cord-010119-t1x9gknd 7831 11 , , , cord-010119-t1x9gknd 7831 12 whose whose WP$ cord-010119-t1x9gknd 7831 13 RBC RBC NNP cord-010119-t1x9gknd 7831 14 were be VBD cord-010119-t1x9gknd 7831 15 1 1 CD cord-010119-t1x9gknd 7831 16 w w NN cord-010119-t1x9gknd 7831 17 at at IN cord-010119-t1x9gknd 7831 18 IS is NN cord-010119-t1x9gknd 7831 19 and and CC cord-010119-t1x9gknd 7831 20 31 31 CD cord-010119-t1x9gknd 7831 21 at at IN cord-010119-t1x9gknd 7831 22 IAT IAT NNP cord-010119-t1x9gknd 7831 23 with with IN cord-010119-t1x9gknd 7831 24 Immucor Immucor NNP cord-010119-t1x9gknd 7831 25 Series Series NNP cord-010119-t1x9gknd 7831 26 4 4 CD cord-010119-t1x9gknd 7831 27 and and CC cord-010119-t1x9gknd 7831 28 5 5 CD cord-010119-t1x9gknd 7831 29 and and CC cord-010119-t1x9gknd 7831 30 Gammaclone Gammaclone NNP cord-010119-t1x9gknd 7831 31 , , , cord-010119-t1x9gknd 7831 32 and and CC cord-010119-t1x9gknd 7831 33 moderately moderately RB cord-010119-t1x9gknd 7831 34 reactive reactive JJ cord-010119-t1x9gknd 7831 35 , , , cord-010119-t1x9gknd 7832 1 21 21 CD cord-010119-t1x9gknd 7832 2 IS is NN cord-010119-t1x9gknd 7832 3 and and CC cord-010119-t1x9gknd 7832 4 41 41 CD cord-010119-t1x9gknd 7832 5 IAT IAT NNP cord-010119-t1x9gknd 7832 6 , , , cord-010119-t1x9gknd 7832 7 with with IN cord-010119-t1x9gknd 7832 8 ALBA ALBA NNP cord-010119-t1x9gknd 7832 9 alpha alpha NN cord-010119-t1x9gknd 7832 10 , , , cord-010119-t1x9gknd 7832 11 ALBA ALBA NNP cord-010119-t1x9gknd 7832 12 blend blend NN cord-010119-t1x9gknd 7832 13 and and CC cord-010119-t1x9gknd 7832 14 delta delta NNP cord-010119-t1x9gknd 7832 15 anti anti NNP cord-010119-t1x9gknd 7832 16 - - NNP cord-010119-t1x9gknd 7832 17 D. D. NNP cord-010119-t1x9gknd 7832 18 RBCs rbc NNS cord-010119-t1x9gknd 7832 19 did do VBD cord-010119-t1x9gknd 7832 20 not not RB cord-010119-t1x9gknd 7832 21 react react VB cord-010119-t1x9gknd 7832 22 with with IN cord-010119-t1x9gknd 7832 23 two two CD cord-010119-t1x9gknd 7832 24 ( ( -LRB- cord-010119-t1x9gknd 7832 25 LHM LHM NNP cord-010119-t1x9gknd 7832 26 174/102 174/102 NNP cord-010119-t1x9gknd 7832 27 & & CC cord-010119-t1x9gknd 7832 28 170/45 170/45 CD cord-010119-t1x9gknd 7832 29 ) ) -RRB- cord-010119-t1x9gknd 7833 1 anti anti JJ cord-010119-t1x9gknd 7833 2 - - JJ cord-010119-t1x9gknd 7833 3 D d JJ cord-010119-t1x9gknd 7833 4 in in IN cord-010119-t1x9gknd 7833 5 the the DT cord-010119-t1x9gknd 7833 6 partial partial JJ cord-010119-t1x9gknd 7833 7 D d NN cord-010119-t1x9gknd 7833 8 kit kit NN cord-010119-t1x9gknd 7833 9 with with IN cord-010119-t1x9gknd 7833 10 no no DT cord-010119-t1x9gknd 7833 11 known know VBN cord-010119-t1x9gknd 7833 12 partial partial JJ cord-010119-t1x9gknd 7833 13 D d NN cord-010119-t1x9gknd 7833 14 pattern pattern NN cord-010119-t1x9gknd 7833 15 . . . cord-010119-t1x9gknd 7834 1 DNA dna NN cord-010119-t1x9gknd 7834 2 testing testing NN cord-010119-t1x9gknd 7834 3 predicted predict VBD cord-010119-t1x9gknd 7834 4 she -PRON- PRP cord-010119-t1x9gknd 7834 5 was be VBD cord-010119-t1x9gknd 7834 6 RHD RHD NNP cord-010119-t1x9gknd 7834 7 hemizygous hemizygous NNP cord-010119-t1x9gknd 7834 8 and and CC cord-010119-t1x9gknd 7834 9 RHD RHD NNP cord-010119-t1x9gknd 7834 10 BeadChip BeadChip NNP cord-010119-t1x9gknd 7835 1 detected detect VBN cord-010119-t1x9gknd 7835 2 markers marker NNS cord-010119-t1x9gknd 7835 3 for for IN cord-010119-t1x9gknd 7835 4 RHD*DAR RHD*DAR NNS cord-010119-t1x9gknd 7835 5 but but CC cord-010119-t1x9gknd 7835 6 exon exon NN cord-010119-t1x9gknd 7835 7 2 2 CD cord-010119-t1x9gknd 7835 8 gave give VBD cord-010119-t1x9gknd 7835 9 low low JJ cord-010119-t1x9gknd 7835 10 signal signal NN cord-010119-t1x9gknd 7835 11 ( ( -LRB- cord-010119-t1x9gknd 7835 12 LS ls NN cord-010119-t1x9gknd 7835 13 ) ) -RRB- cord-010119-t1x9gknd 7835 14 . . . cord-010119-t1x9gknd 7836 1 Sequencing sequencing NN cord-010119-t1x9gknd 7836 2 found find VBD cord-010119-t1x9gknd 7836 3 a a DT cord-010119-t1x9gknd 7836 4 hybrid hybrid JJ cord-010119-t1x9gknd 7836 5 DAR DAR NNP cord-010119-t1x9gknd 7836 6 with with IN cord-010119-t1x9gknd 7836 7 CE ce NN cord-010119-t1x9gknd 7836 8 - - HYPH cord-010119-t1x9gknd 7836 9 specific specific JJ cord-010119-t1x9gknd 7836 10 nucleotides nucleotide NNS cord-010119-t1x9gknd 7836 11 in in IN cord-010119-t1x9gknd 7836 12 exon exon NN cord-010119-t1x9gknd 7836 13 2 2 CD cord-010119-t1x9gknd 7836 14 from from IN cord-010119-t1x9gknd 7836 15 c.150 c.150 VBG cord-010119-t1x9gknd 7836 16 to to IN cord-010119-t1x9gknd 7836 17 c.203 c.203 NNP cord-010119-t1x9gknd 7836 18 encoding encoding NN cord-010119-t1x9gknd 7837 1 amino amino NN cord-010119-t1x9gknd 7837 2 acid acid NN cord-010119-t1x9gknd 7837 3 changes change NNS cord-010119-t1x9gknd 7837 4 p. p. NN cord-010119-t1x9gknd 7838 1 Ile60Leu ile60leu JJ cord-010119-t1x9gknd 7838 2 and and CC cord-010119-t1x9gknd 7838 3 Ser68Asn ser68asn NN cord-010119-t1x9gknd 7838 4 . . . cord-010119-t1x9gknd 7839 1 Conclusion conclusion NN cord-010119-t1x9gknd 7839 2 : : : cord-010119-t1x9gknd 7840 1 We -PRON- PRP cord-010119-t1x9gknd 7840 2 found find VBD cord-010119-t1x9gknd 7840 3 two two CD cord-010119-t1x9gknd 7840 4 previously previously RB cord-010119-t1x9gknd 7840 5 reported report VBN cord-010119-t1x9gknd 7840 6 rare rare JJ cord-010119-t1x9gknd 7840 7 alleles allele NNS cord-010119-t1x9gknd 7840 8 : : : cord-010119-t1x9gknd 7840 9 RHD RHD NNP cord-010119-t1x9gknd 7840 10 with with IN cord-010119-t1x9gknd 7840 11 a a DT cord-010119-t1x9gknd 7840 12 c.780C c.780C NNP cord-010119-t1x9gknd 7841 1 > > XX cord-010119-t1x9gknd 7842 1 A a DT cord-010119-t1x9gknd 7843 1 ( ( -LRB- cord-010119-t1x9gknd 7843 2 p p NN cord-010119-t1x9gknd 7843 3 . . . cord-010119-t1x9gknd 7843 4 His260Gln His260Gln NNPS cord-010119-t1x9gknd 7843 5 ) ) -RRB- cord-010119-t1x9gknd 7843 6 , , , cord-010119-t1x9gknd 7843 7 previously previously RB cord-010119-t1x9gknd 7843 8 found find VBN cord-010119-t1x9gknd 7843 9 in in IN cord-010119-t1x9gknd 7843 10 France France NNP cord-010119-t1x9gknd 7843 11 ( ( -LRB- cord-010119-t1x9gknd 7843 12 LeFloch LeFloch NNP cord-010119-t1x9gknd 7843 13 et et NNP cord-010119-t1x9gknd 7843 14 al al NNP cord-010119-t1x9gknd 7843 15 . . . cord-010119-t1x9gknd 7844 1 GenBank GenBank NNP cord-010119-t1x9gknd 7844 2 KU363612 KU363612 NNP cord-010119-t1x9gknd 7844 3 ) ) -RRB- cord-010119-t1x9gknd 7844 4 , , , cord-010119-t1x9gknd 7844 5 and and CC cord-010119-t1x9gknd 7844 6 RHD*DAR RHD*DAR NNS cord-010119-t1x9gknd 7844 7 with with IN cord-010119-t1x9gknd 7844 8 part part NN cord-010119-t1x9gknd 7844 9 of of IN cord-010119-t1x9gknd 7844 10 exon exon NN cord-010119-t1x9gknd 7844 11 2 2 CD cord-010119-t1x9gknd 7844 12 replaced replace VBN cord-010119-t1x9gknd 7844 13 by by IN cord-010119-t1x9gknd 7844 14 RHCE RHCE NNP cord-010119-t1x9gknd 7844 15 , , , cord-010119-t1x9gknd 7844 16 reported report VBN cord-010119-t1x9gknd 7844 17 in in IN cord-010119-t1x9gknd 7844 18 sub sub JJ cord-010119-t1x9gknd 7844 19 - - JJ cord-010119-t1x9gknd 7844 20 Sahara Sahara NNP cord-010119-t1x9gknd 7844 21 Africa Africa NNP cord-010119-t1x9gknd 7845 1 ( ( -LRB- cord-010119-t1x9gknd 7845 2 Granier Granier NNP cord-010119-t1x9gknd 7845 3 et et NNP cord-010119-t1x9gknd 7845 4 al al NNP cord-010119-t1x9gknd 7845 5 . . . cord-010119-t1x9gknd 7846 1 Transfusion transfusion NN cord-010119-t1x9gknd 7846 2 53:3009 53:3009 CD cord-010119-t1x9gknd 7846 3 ) ) -RRB- cord-010119-t1x9gknd 7846 4 designated designate VBN cord-010119-t1x9gknd 7846 5 RHD*DAR(CE2 RHD*DAR(CE2 NNP cord-010119-t1x9gknd 7846 6 : : : cord-010119-t1x9gknd 7846 7 V505V v505v NN cord-010119-t1x9gknd 7846 8 - - HYPH cord-010119-t1x9gknd 7846 9 S68N S68N NNS cord-010119-t1x9gknd 7846 10 ) ) -RRB- cord-010119-t1x9gknd 7846 11 with with IN cord-010119-t1x9gknd 7846 12 an an DT cord-010119-t1x9gknd 7846 13 allele allele NN cord-010119-t1x9gknd 7846 14 frequency frequency NN cord-010119-t1x9gknd 7846 15 of of IN cord-010119-t1x9gknd 7846 16 0.002 0.002 CD cord-010119-t1x9gknd 7846 17 to to IN cord-010119-t1x9gknd 7846 18 0.016 0.016 CD cord-010119-t1x9gknd 7846 19 . . . cord-010119-t1x9gknd 7847 1 Blood blood NN cord-010119-t1x9gknd 7847 2 samples sample NNS cord-010119-t1x9gknd 7847 3 were be VBD cord-010119-t1x9gknd 7847 4 not not RB cord-010119-t1x9gknd 7847 5 available available JJ cord-010119-t1x9gknd 7847 6 to to TO cord-010119-t1x9gknd 7847 7 test test VB cord-010119-t1x9gknd 7847 8 for for IN cord-010119-t1x9gknd 7847 9 alterations alteration NNS cord-010119-t1x9gknd 7847 10 in in IN cord-010119-t1x9gknd 7847 11 D d NN cord-010119-t1x9gknd 7847 12 expression expression NN cord-010119-t1x9gknd 7847 13 for for IN cord-010119-t1x9gknd 7847 14 either either DT cord-010119-t1x9gknd 7847 15 allele allele NN cord-010119-t1x9gknd 7847 16 . . . cord-010119-t1x9gknd 7848 1 We -PRON- PRP cord-010119-t1x9gknd 7848 2 provide provide VBP cord-010119-t1x9gknd 7848 3 serologic serologic JJ cord-010119-t1x9gknd 7848 4 evidence evidence NN cord-010119-t1x9gknd 7848 5 that that IN cord-010119-t1x9gknd 7848 6 these these DT cord-010119-t1x9gknd 7848 7 alleles allele NNS cord-010119-t1x9gknd 7848 8 , , , cord-010119-t1x9gknd 7848 9 found find VBN cord-010119-t1x9gknd 7848 10 in in IN cord-010119-t1x9gknd 7848 11 two two CD cord-010119-t1x9gknd 7848 12 females female NNS cord-010119-t1x9gknd 7848 13 evaluated evaluate VBN cord-010119-t1x9gknd 7848 14 by by IN cord-010119-t1x9gknd 7848 15 RHD RHD NNP cord-010119-t1x9gknd 7848 16 genotyping genotyping NN cord-010119-t1x9gknd 7848 17 , , , cord-010119-t1x9gknd 7848 18 inform inform VB cord-010119-t1x9gknd 7848 19 transfusion transfusion NN cord-010119-t1x9gknd 7848 20 and and CC cord-010119-t1x9gknd 7848 21 Rh Rh NNP cord-010119-t1x9gknd 7848 22 immune immune JJ cord-010119-t1x9gknd 7848 23 globulin globulin NN cord-010119-t1x9gknd 7848 24 prophylaxis prophylaxis NN cord-010119-t1x9gknd 7848 25 , , , cord-010119-t1x9gknd 7848 26 as as IN cord-010119-t1x9gknd 7848 27 they -PRON- PRP cord-010119-t1x9gknd 7848 28 encode encode VBP cord-010119-t1x9gknd 7848 29 partial partial JJ cord-010119-t1x9gknd 7848 30 D d NN cord-010119-t1x9gknd 7848 31 phenotypes phenotype NNS cord-010119-t1x9gknd 7848 32 with with IN cord-010119-t1x9gknd 7848 33 novel novel NN cord-010119-t1x9gknd 7848 34 epitope epitope NN cord-010119-t1x9gknd 7848 35 expression expression NN cord-010119-t1x9gknd 7848 36 patterns pattern NNS cord-010119-t1x9gknd 7848 37 , , , cord-010119-t1x9gknd 7848 38 meaning mean VBG cord-010119-t1x9gknd 7848 39 these these DT cord-010119-t1x9gknd 7848 40 patients patient NNS cord-010119-t1x9gknd 7848 41 are be VBP cord-010119-t1x9gknd 7848 42 at at IN cord-010119-t1x9gknd 7848 43 risk risk NN cord-010119-t1x9gknd 7848 44 of of IN cord-010119-t1x9gknd 7848 45 forming form VBG cord-010119-t1x9gknd 7848 46 allo allo NNP cord-010119-t1x9gknd 7848 47 anti anti NNP cord-010119-t1x9gknd 7848 48 - - NNP cord-010119-t1x9gknd 7848 49 D. D. NNP cord-010119-t1x9gknd 7848 50 Background Background NNP cord-010119-t1x9gknd 7848 51 / / SYM cord-010119-t1x9gknd 7848 52 Case Case NNP cord-010119-t1x9gknd 7848 53 Studies Studies NNPS cord-010119-t1x9gknd 7848 54 : : : cord-010119-t1x9gknd 7848 55 Hu5F9-G4 Hu5F9-G4 NNP cord-010119-t1x9gknd 7848 56 is be VBZ cord-010119-t1x9gknd 7848 57 a a DT cord-010119-t1x9gknd 7848 58 human human JJ cord-010119-t1x9gknd 7848 59 monoclonal monoclonal JJ cord-010119-t1x9gknd 7848 60 IgG4 igg4 CD cord-010119-t1x9gknd 7848 61 antibody antibody NN cord-010119-t1x9gknd 7848 62 recognizing recognize VBG cord-010119-t1x9gknd 7848 63 CD47 CD47 NNP cord-010119-t1x9gknd 7849 1 that that DT cord-010119-t1x9gknd 7849 2 is be VBZ cord-010119-t1x9gknd 7849 3 in in IN cord-010119-t1x9gknd 7849 4 clinical clinical JJ cord-010119-t1x9gknd 7849 5 trials trial NNS cord-010119-t1x9gknd 7849 6 to to TO cord-010119-t1x9gknd 7849 7 treat treat VB cord-010119-t1x9gknd 7849 8 hematologic hematologic JJ cord-010119-t1x9gknd 7849 9 or or CC cord-010119-t1x9gknd 7849 10 solid solid JJ cord-010119-t1x9gknd 7849 11 malignancies malignancy NNS cord-010119-t1x9gknd 7849 12 . . . cord-010119-t1x9gknd 7850 1 CD47 CD47 NNP cord-010119-t1x9gknd 7850 2 is be VBZ cord-010119-t1x9gknd 7850 3 a a DT cord-010119-t1x9gknd 7850 4 transmembrane transmembrane NN cord-010119-t1x9gknd 7850 5 glycoprotein glycoprotein NN cord-010119-t1x9gknd 7850 6 that that WDT cord-010119-t1x9gknd 7850 7 binds bind VBZ cord-010119-t1x9gknd 7850 8 to to IN cord-010119-t1x9gknd 7850 9 signalregulatory signalregulatory JJ cord-010119-t1x9gknd 7850 10 protein protein NNP cord-010119-t1x9gknd 7850 11 a a DT cord-010119-t1x9gknd 7850 12 ( ( -LRB- cord-010119-t1x9gknd 7850 13 SIRPa SIRPa NNS cord-010119-t1x9gknd 7850 14 ) ) -RRB- cord-010119-t1x9gknd 7850 15 on on IN cord-010119-t1x9gknd 7850 16 macrophages macrophage NNS cord-010119-t1x9gknd 7850 17 and and CC cord-010119-t1x9gknd 7850 18 functions function NNS cord-010119-t1x9gknd 7850 19 to to TO cord-010119-t1x9gknd 7850 20 regulate regulate VB cord-010119-t1x9gknd 7850 21 phagocytosis phagocytosis NN cord-010119-t1x9gknd 7850 22 . . . cord-010119-t1x9gknd 7851 1 Blocking block VBG cord-010119-t1x9gknd 7851 2 CD47 CD47 NNP cord-010119-t1x9gknd 7851 3 is be VBZ cord-010119-t1x9gknd 7851 4 thought think VBN cord-010119-t1x9gknd 7851 5 to to TO cord-010119-t1x9gknd 7851 6 enhance enhance VB cord-010119-t1x9gknd 7851 7 phagocytosis phagocytosis NN cord-010119-t1x9gknd 7851 8 and and CC cord-010119-t1x9gknd 7851 9 promote promote VB cord-010119-t1x9gknd 7851 10 anti anti JJ cord-010119-t1x9gknd 7851 11 - - JJ cord-010119-t1x9gknd 7851 12 tumor tumor JJ cord-010119-t1x9gknd 7851 13 responses response NNS cord-010119-t1x9gknd 7851 14 . . . cord-010119-t1x9gknd 7852 1 CD47 CD47 NNP cord-010119-t1x9gknd 7852 2 is be VBZ cord-010119-t1x9gknd 7852 3 also also RB cord-010119-t1x9gknd 7852 4 highly highly RB cord-010119-t1x9gknd 7852 5 expressed express VBN cord-010119-t1x9gknd 7852 6 on on IN cord-010119-t1x9gknd 7852 7 RBCs rbc NNS cord-010119-t1x9gknd 7852 8 , , , cord-010119-t1x9gknd 7852 9 and and CC cord-010119-t1x9gknd 7852 10 the the DT cord-010119-t1x9gknd 7852 11 purpose purpose NN cord-010119-t1x9gknd 7852 12 of of IN cord-010119-t1x9gknd 7852 13 this this DT cord-010119-t1x9gknd 7852 14 study study NN cord-010119-t1x9gknd 7852 15 was be VBD cord-010119-t1x9gknd 7852 16 to to TO cord-010119-t1x9gknd 7852 17 evaluate evaluate VB cord-010119-t1x9gknd 7852 18 anti anti JJ cord-010119-t1x9gknd 7852 19 - - JJ cord-010119-t1x9gknd 7852 20 CD47 cd47 JJ cord-010119-t1x9gknd 7852 21 drug drug NN cord-010119-t1x9gknd 7852 22 interference interference NN cord-010119-t1x9gknd 7852 23 in in IN cord-010119-t1x9gknd 7852 24 blood blood NN cord-010119-t1x9gknd 7852 25 bank bank NN cord-010119-t1x9gknd 7852 26 testing testing NN cord-010119-t1x9gknd 7852 27 . . . cord-010119-t1x9gknd 7853 1 Study Study NNP cord-010119-t1x9gknd 7853 2 Design Design NNP cord-010119-t1x9gknd 7853 3 / / SYM cord-010119-t1x9gknd 7853 4 Method method NN cord-010119-t1x9gknd 7853 5 : : : cord-010119-t1x9gknd 7853 6 Serologic Serologic NNP cord-010119-t1x9gknd 7853 7 testing testing NN cord-010119-t1x9gknd 7853 8 was be VBD cord-010119-t1x9gknd 7853 9 performed perform VBN cord-010119-t1x9gknd 7853 10 by by IN cord-010119-t1x9gknd 7853 11 standard standard JJ cord-010119-t1x9gknd 7853 12 methods method NNS cord-010119-t1x9gknd 7853 13 . . . cord-010119-t1x9gknd 7854 1 Serial serial JJ cord-010119-t1x9gknd 7854 2 samples sample NNS cord-010119-t1x9gknd 7854 3 ( ( -LRB- cord-010119-t1x9gknd 7854 4 n57 n57 NN cord-010119-t1x9gknd 7854 5 ) ) -RRB- cord-010119-t1x9gknd 7854 6 from from IN cord-010119-t1x9gknd 7854 7 2 2 CD cord-010119-t1x9gknd 7854 8 patients patient NNS cord-010119-t1x9gknd 7854 9 were be VBD cord-010119-t1x9gknd 7854 10 tested test VBN cord-010119-t1x9gknd 7854 11 over over IN cord-010119-t1x9gknd 7854 12 the the DT cord-010119-t1x9gknd 7854 13 course course NN cord-010119-t1x9gknd 7854 14 of of IN cord-010119-t1x9gknd 7854 15 1 1 CD cord-010119-t1x9gknd 7854 16 month month NN cord-010119-t1x9gknd 7854 17 treatment treatment NN cord-010119-t1x9gknd 7854 18 . . . cord-010119-t1x9gknd 7855 1 Plasma plasma NN cord-010119-t1x9gknd 7855 2 was be VBD cord-010119-t1x9gknd 7855 3 tested test VBN cord-010119-t1x9gknd 7855 4 at at IN cord-010119-t1x9gknd 7855 5 immediate immediate JJ cord-010119-t1x9gknd 7855 6 spin spin NN cord-010119-t1x9gknd 7855 7 ( ( -LRB- cord-010119-t1x9gknd 7855 8 IS be VBZ cord-010119-t1x9gknd 7855 9 ) ) -RRB- cord-010119-t1x9gknd 7855 10 and and CC cord-010119-t1x9gknd 7855 11 by by IN cord-010119-t1x9gknd 7855 12 IAT IAT NNP cord-010119-t1x9gknd 7855 13 with with IN cord-010119-t1x9gknd 7855 14 R2R2 R2R2 NNP cord-010119-t1x9gknd 7855 15 , , , cord-010119-t1x9gknd 7855 16 rr rr NNP cord-010119-t1x9gknd 7855 17 , , , cord-010119-t1x9gknd 7855 18 D-- D-- NNP cord-010119-t1x9gknd 7855 19 , , , cord-010119-t1x9gknd 7855 20 Rh Rh NNP cord-010119-t1x9gknd 7855 21 mod mod NN cord-010119-t1x9gknd 7855 22 and and CC cord-010119-t1x9gknd 7855 23 Rh Rh NNP cord-010119-t1x9gknd 7855 24 null null JJ cord-010119-t1x9gknd 7855 25 RBCs rbc NNS cord-010119-t1x9gknd 7855 26 , , , cord-010119-t1x9gknd 7855 27 as as IN cord-010119-t1x9gknd 7855 28 CD47 CD47 NNP cord-010119-t1x9gknd 7855 29 expression expression NN cord-010119-t1x9gknd 7855 30 levels level NNS cord-010119-t1x9gknd 7855 31 vary vary VBP cord-010119-t1x9gknd 7855 32 depending depend VBG cord-010119-t1x9gknd 7855 33 on on IN cord-010119-t1x9gknd 7855 34 Rh Rh NNP cord-010119-t1x9gknd 7855 35 phenotype phenotype NN cord-010119-t1x9gknd 7855 36 . . . cord-010119-t1x9gknd 7856 1 DTT DTT NNP cord-010119-t1x9gknd 7856 2 and and CC cord-010119-t1x9gknd 7856 3 enzyme enzyme NN cord-010119-t1x9gknd 7856 4 treated treat VBN cord-010119-t1x9gknd 7856 5 RBCs rbc NNS cord-010119-t1x9gknd 7856 6 were be VBD cord-010119-t1x9gknd 7856 7 also also RB cord-010119-t1x9gknd 7856 8 tested test VBN cord-010119-t1x9gknd 7856 9 . . . cord-010119-t1x9gknd 7857 1 Both both DT cord-010119-t1x9gknd 7857 2 Immucor Immucor NNP cord-010119-t1x9gknd 7857 3 Gamma Gamma NNP cord-010119-t1x9gknd 7857 4 - - HYPH cord-010119-t1x9gknd 7857 5 clone clone NN cord-010119-t1x9gknd 7857 6 anti anti JJ cord-010119-t1x9gknd 7857 7 - - JJ cord-010119-t1x9gknd 7857 8 IgG igg JJ cord-010119-t1x9gknd 7857 9 ( ( -LRB- cord-010119-t1x9gknd 7857 10 does do VBZ cord-010119-t1x9gknd 7857 11 not not RB cord-010119-t1x9gknd 7857 12 detect detect VB cord-010119-t1x9gknd 7857 13 IgG4 igg4 CD cord-010119-t1x9gknd 7857 14 ) ) -RRB- cord-010119-t1x9gknd 7857 15 and and CC cord-010119-t1x9gknd 7858 1 Ortho Ortho NNP cord-010119-t1x9gknd 7858 2 BioClone BioClone NNP cord-010119-t1x9gknd 7858 3 anti anti JJ cord-010119-t1x9gknd 7858 4 - - JJ cord-010119-t1x9gknd 7858 5 IgG igg JJ cord-010119-t1x9gknd 7858 6 ( ( -LRB- cord-010119-t1x9gknd 7858 7 total total JJ cord-010119-t1x9gknd 7858 8 IgG IgG NNP cord-010119-t1x9gknd 7858 9 ) ) -RRB- cord-010119-t1x9gknd 7858 10 were be VBD cord-010119-t1x9gknd 7858 11 used use VBN cord-010119-t1x9gknd 7858 12 . . . cord-010119-t1x9gknd 7859 1 For for IN cord-010119-t1x9gknd 7859 2 titration titration NN cord-010119-t1x9gknd 7859 3 plasma plasma NN cord-010119-t1x9gknd 7859 4 was be VBD cord-010119-t1x9gknd 7859 5 diluted dilute VBN cord-010119-t1x9gknd 7859 6 in in IN cord-010119-t1x9gknd 7859 7 PBS PBS NNP cord-010119-t1x9gknd 7859 8 . . . cord-010119-t1x9gknd 7860 1 Allo allo NN cord-010119-t1x9gknd 7860 2 - - HYPH cord-010119-t1x9gknd 7860 3 adsorptions adsorption NNS cord-010119-t1x9gknd 7860 4 were be VBD cord-010119-t1x9gknd 7860 5 performed perform VBN cord-010119-t1x9gknd 7860 6 with with IN cord-010119-t1x9gknd 7860 7 papain papain NN cord-010119-t1x9gknd 7860 8 treated treat VBN cord-010119-t1x9gknd 7860 9 rr rr NN cord-010119-t1x9gknd 7860 10 RBCs rbc NNS cord-010119-t1x9gknd 7860 11 and and CC cord-010119-t1x9gknd 7860 12 eluates eluates NNPS cord-010119-t1x9gknd 7860 13 were be VBD cord-010119-t1x9gknd 7860 14 made make VBN cord-010119-t1x9gknd 7860 15 using use VBG cord-010119-t1x9gknd 7860 16 Gamma Gamma NNP cord-010119-t1x9gknd 7860 17 ELU ELU NNP cord-010119-t1x9gknd 7860 18 - - HYPH cord-010119-t1x9gknd 7860 19 KIT KIT NNP cord-010119-t1x9gknd 7860 20 II II NNP cord-010119-t1x9gknd 7860 21 . . . cord-010119-t1x9gknd 7861 1 Results/ Results/ . cord-010119-t1x9gknd 7862 1 Finding finding NN cord-010119-t1x9gknd 7862 2 : : : cord-010119-t1x9gknd 7863 1 Anti Anti NNP cord-010119-t1x9gknd 7863 2 - - NNP cord-010119-t1x9gknd 7863 3 CD47 CD47 NNP cord-010119-t1x9gknd 7863 4 was be VBD cord-010119-t1x9gknd 7863 5 observed observe VBN cord-010119-t1x9gknd 7863 6 in in IN cord-010119-t1x9gknd 7863 7 plasma plasma NN cord-010119-t1x9gknd 7863 8 as as RB cord-010119-t1x9gknd 7863 9 soon soon RB cord-010119-t1x9gknd 7863 10 as as IN cord-010119-t1x9gknd 7863 11 1 1 CD cord-010119-t1x9gknd 7863 12 hour hour NN cord-010119-t1x9gknd 7863 13 post post NN cord-010119-t1x9gknd 7863 14 infusion infusion NN cord-010119-t1x9gknd 7863 15 . . . cord-010119-t1x9gknd 7864 1 Plasma plasma NN cord-010119-t1x9gknd 7864 2 reacted react VBD cord-010119-t1x9gknd 7864 3 31 31 CD cord-010119-t1x9gknd 7864 4 to to IN cord-010119-t1x9gknd 7864 5 41 41 CD cord-010119-t1x9gknd 7864 6 at at IN cord-010119-t1x9gknd 7864 7 IS is NN cord-010119-t1x9gknd 7864 8 and and CC cord-010119-t1x9gknd 7864 9 41 41 CD cord-010119-t1x9gknd 7864 10 with with IN cord-010119-t1x9gknd 7864 11 all all DT cord-010119-t1x9gknd 7864 12 panel panel NN cord-010119-t1x9gknd 7864 13 cells cell NNS cord-010119-t1x9gknd 7864 14 in in IN cord-010119-t1x9gknd 7864 15 PEG PEG NNP cord-010119-t1x9gknd 7864 16 IAT IAT NNP cord-010119-t1x9gknd 7864 17 using use VBG cord-010119-t1x9gknd 7864 18 Ortho Ortho NNP cord-010119-t1x9gknd 7865 1 anti anti JJ cord-010119-t1x9gknd 7865 2 - - NNP cord-010119-t1x9gknd 7865 3 IgG. IgG. NNP cord-010119-t1x9gknd 7865 4 D-- d-- NN cord-010119-t1x9gknd 7865 5 , , , cord-010119-t1x9gknd 7865 6 Rh Rh NNP cord-010119-t1x9gknd 7865 7 mod mod NN cord-010119-t1x9gknd 7865 8 and and CC cord-010119-t1x9gknd 7865 9 Rh Rh NNP cord-010119-t1x9gknd 7865 10 null null JJ cord-010119-t1x9gknd 7865 11 RBCs rbc NNS cord-010119-t1x9gknd 7865 12 were be VBD cord-010119-t1x9gknd 7865 13 nonreactive nonreactive JJ cord-010119-t1x9gknd 7865 14 at at IN cord-010119-t1x9gknd 7865 15 IS is NN cord-010119-t1x9gknd 7865 16 and and CC cord-010119-t1x9gknd 7865 17 weaker weak JJR cord-010119-t1x9gknd 7865 18 ( ( -LRB- cord-010119-t1x9gknd 7865 19 31 31 CD cord-010119-t1x9gknd 7865 20 and and CC cord-010119-t1x9gknd 7865 21 21 21 CD cord-010119-t1x9gknd 7865 22 ) ) -RRB- cord-010119-t1x9gknd 7865 23 in in IN cord-010119-t1x9gknd 7865 24 PEG PEG NNP cord-010119-t1x9gknd 7865 25 IAT IAT NNP cord-010119-t1x9gknd 7865 26 with with IN cord-010119-t1x9gknd 7865 27 Ortho Ortho NNP cord-010119-t1x9gknd 7865 28 reagent reagent NN cord-010119-t1x9gknd 7865 29 . . . cord-010119-t1x9gknd 7866 1 Reactivity reactivity NN cord-010119-t1x9gknd 7866 2 with with IN cord-010119-t1x9gknd 7866 3 all all DT cord-010119-t1x9gknd 7866 4 panel panel NN cord-010119-t1x9gknd 7866 5 cells cell NNS cord-010119-t1x9gknd 7866 6 by by IN cord-010119-t1x9gknd 7866 7 Ortho Ortho NNP cord-010119-t1x9gknd 7866 8 IgG igg NN cord-010119-t1x9gknd 7866 9 gel gel NN cord-010119-t1x9gknd 7866 10 card card NN cord-010119-t1x9gknd 7866 11 was be VBD cord-010119-t1x9gknd 7866 12 31 31 CD cord-010119-t1x9gknd 7866 13 . . . cord-010119-t1x9gknd 7867 1 In in IN cord-010119-t1x9gknd 7867 2 contrast contrast NN cord-010119-t1x9gknd 7867 3 , , , cord-010119-t1x9gknd 7867 4 IAT IAT NNP cord-010119-t1x9gknd 7867 5 reactivity reactivity NN cord-010119-t1x9gknd 7867 6 using use VBG cord-010119-t1x9gknd 7867 7 Gamma gamma NN cord-010119-t1x9gknd 7867 8 - - HYPH cord-010119-t1x9gknd 7867 9 clone clone NN cord-010119-t1x9gknd 7867 10 anti anti JJ cord-010119-t1x9gknd 7867 11 - - JJ cord-010119-t1x9gknd 7867 12 IgG IgG NNP cord-010119-t1x9gknd 7867 13 was be VBD cord-010119-t1x9gknd 7867 14 only only RB cord-010119-t1x9gknd 7867 15 1 1 CD cord-010119-t1x9gknd 7867 16 w w NN cord-010119-t1x9gknd 7867 17 to to IN cord-010119-t1x9gknd 7867 18 11 11 CD cord-010119-t1x9gknd 7867 19 , , , cord-010119-t1x9gknd 7867 20 and and CC cord-010119-t1x9gknd 7867 21 this this DT cord-010119-t1x9gknd 7867 22 reactivity reactivity NN cord-010119-t1x9gknd 7867 23 was be VBD cord-010119-t1x9gknd 7867 24 confirmed confirm VBN cord-010119-t1x9gknd 7867 25 to to TO cord-010119-t1x9gknd 7867 26 be be VB cord-010119-t1x9gknd 7867 27 carry carry VB cord-010119-t1x9gknd 7867 28 - - HYPH cord-010119-t1x9gknd 7867 29 over over RP cord-010119-t1x9gknd 7867 30 agglutination agglutination NN cord-010119-t1x9gknd 7867 31 . . . cord-010119-t1x9gknd 7868 1 D-- D-- NNP cord-010119-t1x9gknd 7868 2 , , , cord-010119-t1x9gknd 7868 3 Rh Rh NNP cord-010119-t1x9gknd 7868 4 mod mod NN cord-010119-t1x9gknd 7868 5 and and CC cord-010119-t1x9gknd 7868 6 Rh Rh NNP cord-010119-t1x9gknd 7868 7 null null NN cord-010119-t1x9gknd 7868 8 were be VBD cord-010119-t1x9gknd 7868 9 non non JJ cord-010119-t1x9gknd 7868 10 - - JJ cord-010119-t1x9gknd 7868 11 reactive reactive JJ cord-010119-t1x9gknd 7868 12 in in IN cord-010119-t1x9gknd 7868 13 PEG PEG NNP cord-010119-t1x9gknd 7868 14 IAT IAT NNP cord-010119-t1x9gknd 7868 15 using use VBG cord-010119-t1x9gknd 7868 16 Gamma gamma NN cord-010119-t1x9gknd 7868 17 - - HYPH cord-010119-t1x9gknd 7868 18 clone clone NN cord-010119-t1x9gknd 7868 19 anti anti JJ cord-010119-t1x9gknd 7868 20 - - JJ cord-010119-t1x9gknd 7868 21 IgG IgG NNP cord-010119-t1x9gknd 7868 22 . . . cord-010119-t1x9gknd 7869 1 The the DT cord-010119-t1x9gknd 7869 2 anti anti JJ cord-010119-t1x9gknd 7869 3 - - JJ cord-010119-t1x9gknd 7869 4 CD47 cd47 JJ cord-010119-t1x9gknd 7869 5 titer titer NN cord-010119-t1x9gknd 7869 6 was be VBD cord-010119-t1x9gknd 7869 7 1 1 CD cord-010119-t1x9gknd 7869 8 at at IN cord-010119-t1x9gknd 7869 9 IS is NN cord-010119-t1x9gknd 7869 10 and and CC cord-010119-t1x9gknd 7869 11 PEG PEG NNP cord-010119-t1x9gknd 7869 12 IAT IAT NNP cord-010119-t1x9gknd 7869 13 with with IN cord-010119-t1x9gknd 7869 14 Gamma gamma NN cord-010119-t1x9gknd 7869 15 - - HYPH cord-010119-t1x9gknd 7869 16 clone clone NN cord-010119-t1x9gknd 7869 17 anti anti JJ cord-010119-t1x9gknd 7869 18 - - JJ cord-010119-t1x9gknd 7869 19 IgG igg JJ cord-010119-t1x9gknd 7869 20 , , , cord-010119-t1x9gknd 7869 21 but but CC cord-010119-t1x9gknd 7869 22 was be VBD cord-010119-t1x9gknd 7869 23 ! ! . cord-010119-t1x9gknd 7870 1 256 256 CD cord-010119-t1x9gknd 7870 2 with with IN cord-010119-t1x9gknd 7871 1 Ortho Ortho NNP cord-010119-t1x9gknd 7871 2 anti anti JJ cord-010119-t1x9gknd 7871 3 - - NNP cord-010119-t1x9gknd 7871 4 IgG. IgG. NNP cord-010119-t1x9gknd 7871 5 Plasma Plasma NNP cord-010119-t1x9gknd 7871 6 reacted react VBD cord-010119-t1x9gknd 7871 7 with with IN cord-010119-t1x9gknd 7871 8 DTT DTT NNP cord-010119-t1x9gknd 7871 9 , , , cord-010119-t1x9gknd 7871 10 trypsin trypsin NN cord-010119-t1x9gknd 7871 11 , , , cord-010119-t1x9gknd 7871 12 papain papain NN cord-010119-t1x9gknd 7871 13 , , , cord-010119-t1x9gknd 7871 14 a a DT cord-010119-t1x9gknd 7871 15 - - HYPH cord-010119-t1x9gknd 7871 16 chymotrypsin chymotrypsin NN cord-010119-t1x9gknd 7871 17 or or CC cord-010119-t1x9gknd 7871 18 W.A.R.M. W.A.R.M. NNP cord-010119-t1x9gknd 7871 19 treated treated JJ cord-010119-t1x9gknd 7871 20 RBCs rbc NNS cord-010119-t1x9gknd 7871 21 . . . cord-010119-t1x9gknd 7872 1 Somewhat somewhat RB cord-010119-t1x9gknd 7872 2 unexpected unexpected JJ cord-010119-t1x9gknd 7872 3 , , , cord-010119-t1x9gknd 7872 4 autocontrols autocontrol NNS cord-010119-t1x9gknd 7872 5 were be VBD cord-010119-t1x9gknd 7872 6 negative negative JJ cord-010119-t1x9gknd 7872 7 and and CC cord-010119-t1x9gknd 7872 8 DATs DATs NNPS cord-010119-t1x9gknd 7872 9 were be VBD cord-010119-t1x9gknd 7872 10 non non JJ cord-010119-t1x9gknd 7872 11 - - JJ cord-010119-t1x9gknd 7872 12 reactive reactive JJ cord-010119-t1x9gknd 7872 13 or or CC cord-010119-t1x9gknd 7872 14 microscopic microscopic JJ cord-010119-t1x9gknd 7872 15 only only RB cord-010119-t1x9gknd 7872 16 . . . cord-010119-t1x9gknd 7873 1 Acid acid NN cord-010119-t1x9gknd 7873 2 eluates eluate NNS cord-010119-t1x9gknd 7873 3 ( ( -LRB- cord-010119-t1x9gknd 7873 4 n54 n54 NN cord-010119-t1x9gknd 7873 5 ) ) -RRB- cord-010119-t1x9gknd 7873 6 were be VBD cord-010119-t1x9gknd 7873 7 31 31 CD cord-010119-t1x9gknd 7873 8 reactive reactive JJ cord-010119-t1x9gknd 7873 9 with with IN cord-010119-t1x9gknd 7873 10 Ortho Ortho NNP cord-010119-t1x9gknd 7873 11 , , , cord-010119-t1x9gknd 7873 12 and and CC cord-010119-t1x9gknd 7873 13 non non JJ cord-010119-t1x9gknd 7873 14 - - JJ cord-010119-t1x9gknd 7873 15 reactive reactive JJ cord-010119-t1x9gknd 7873 16 with with IN cord-010119-t1x9gknd 7873 17 Gamma gamma NN cord-010119-t1x9gknd 7873 18 - - HYPH cord-010119-t1x9gknd 7873 19 clone clone NN cord-010119-t1x9gknd 7873 20 anti anti JJ cord-010119-t1x9gknd 7873 21 - - NNP cord-010119-t1x9gknd 7873 22 IgG. IgG. NNP cord-010119-t1x9gknd 7873 23 Plasma Plasma NNP cord-010119-t1x9gknd 7873 24 reactivity reactivity NN cord-010119-t1x9gknd 7873 25 was be VBD cord-010119-t1x9gknd 7873 26 removed remove VBN cord-010119-t1x9gknd 7873 27 after after IN cord-010119-t1x9gknd 7873 28 4X 4x CD cord-010119-t1x9gknd 7873 29 allo allo NN cord-010119-t1x9gknd 7873 30 - - HYPH cord-010119-t1x9gknd 7873 31 adsorption adsorption NN cord-010119-t1x9gknd 7873 32 with with IN cord-010119-t1x9gknd 7873 33 papain papain NN cord-010119-t1x9gknd 7873 34 treated treat VBN cord-010119-t1x9gknd 7873 35 rr rr NN cord-010119-t1x9gknd 7873 36 cells cell NNS cord-010119-t1x9gknd 7873 37 , , , cord-010119-t1x9gknd 7873 38 but but CC cord-010119-t1x9gknd 7873 39 in in IN cord-010119-t1x9gknd 7873 40 some some DT cord-010119-t1x9gknd 7873 41 samples sample NNS cord-010119-t1x9gknd 7873 42 low low JJ cord-010119-t1x9gknd 7873 43 level level NN cord-010119-t1x9gknd 7873 44 ( ( -LRB- cord-010119-t1x9gknd 7873 45 micro-11 micro-11 NNS cord-010119-t1x9gknd 7873 46 ) ) -RRB- cord-010119-t1x9gknd 7873 47 reactivity reactivity NN cord-010119-t1x9gknd 7873 48 remained remain VBD cord-010119-t1x9gknd 7873 49 . . . cord-010119-t1x9gknd 7874 1 PEG PEG NNP cord-010119-t1x9gknd 7874 2 adsorption adsorption NN cord-010119-t1x9gknd 7874 3 was be VBD cord-010119-t1x9gknd 7874 4 invalid invalid JJ cord-010119-t1x9gknd 7874 5 due due IN cord-010119-t1x9gknd 7874 6 to to IN cord-010119-t1x9gknd 7874 7 precipitation precipitation NN cord-010119-t1x9gknd 7874 8 / / SYM cord-010119-t1x9gknd 7874 9 complexing complexing NN cord-010119-t1x9gknd 7874 10 of of IN cord-010119-t1x9gknd 7874 11 antibody antibody NN cord-010119-t1x9gknd 7874 12 . . . cord-010119-t1x9gknd 7875 1 Robust robust JJ cord-010119-t1x9gknd 7875 2 plasma plasma NN cord-010119-t1x9gknd 7875 3 reactivity reactivity NN cord-010119-t1x9gknd 7875 4 interferring interferre VBG cord-010119-t1x9gknd 7875 5 in in IN cord-010119-t1x9gknd 7875 6 ABO ABO NNP cord-010119-t1x9gknd 7875 7 reverse reverse NN cord-010119-t1x9gknd 7875 8 typing typing NN cord-010119-t1x9gknd 7875 9 was be VBD cord-010119-t1x9gknd 7875 10 observed observe VBN cord-010119-t1x9gknd 7875 11 , , , cord-010119-t1x9gknd 7875 12 and and CC cord-010119-t1x9gknd 7875 13 weak weak JJ cord-010119-t1x9gknd 7875 14 spontaneous spontaneous JJ cord-010119-t1x9gknd 7875 15 agglutination agglutination NN cord-010119-t1x9gknd 7875 16 of of IN cord-010119-t1x9gknd 7875 17 the the DT cord-010119-t1x9gknd 7875 18 RBCs rbc NNS cord-010119-t1x9gknd 7875 19 in in IN cord-010119-t1x9gknd 7875 20 the the DT cord-010119-t1x9gknd 7875 21 ABO ABO NNP cord-010119-t1x9gknd 7875 22 forward forward RB cord-010119-t1x9gknd 7875 23 and and CC cord-010119-t1x9gknd 7875 24 Rh Rh NNP cord-010119-t1x9gknd 7875 25 typing typing NN cord-010119-t1x9gknd 7875 26 . . . cord-010119-t1x9gknd 7876 1 Conclusion conclusion NN cord-010119-t1x9gknd 7876 2 : : : cord-010119-t1x9gknd 7876 3 Hu5F9-G4 hu5f9-g4 XX cord-010119-t1x9gknd 7877 1 anti anti JJ cord-010119-t1x9gknd 7877 2 - - JJ cord-010119-t1x9gknd 7877 3 CD47 cd47 JJ cord-010119-t1x9gknd 7877 4 therapy therapy NN cord-010119-t1x9gknd 7877 5 interferes interfere VBZ cord-010119-t1x9gknd 7877 6 with with IN cord-010119-t1x9gknd 7877 7 routine routine JJ cord-010119-t1x9gknd 7877 8 pretransfusion pretransfusion NN cord-010119-t1x9gknd 7877 9 testing testing NN cord-010119-t1x9gknd 7877 10 , , , cord-010119-t1x9gknd 7877 11 not not RB cord-010119-t1x9gknd 7877 12 only only RB cord-010119-t1x9gknd 7877 13 antibody antibody NN cord-010119-t1x9gknd 7877 14 screening screening NN cord-010119-t1x9gknd 7877 15 and and CC cord-010119-t1x9gknd 7877 16 crossmatch crossmatch NN cord-010119-t1x9gknd 7877 17 , , , cord-010119-t1x9gknd 7877 18 but but CC cord-010119-t1x9gknd 7877 19 ABO ABO NNP cord-010119-t1x9gknd 7877 20 and and CC cord-010119-t1x9gknd 7877 21 Rh Rh NNP cord-010119-t1x9gknd 7877 22 typing typing NN cord-010119-t1x9gknd 7877 23 . . . cord-010119-t1x9gknd 7878 1 High high JJ cord-010119-t1x9gknd 7878 2 levels level NNS cord-010119-t1x9gknd 7878 3 of of IN cord-010119-t1x9gknd 7878 4 CD47 cd47 JJ cord-010119-t1x9gknd 7878 5 expression expression NN cord-010119-t1x9gknd 7878 6 on on IN cord-010119-t1x9gknd 7878 7 RBCs rbc NNS cord-010119-t1x9gknd 7878 8 results result NNS cord-010119-t1x9gknd 7878 9 in in IN cord-010119-t1x9gknd 7878 10 plasma plasma NN cord-010119-t1x9gknd 7878 11 agglutination agglutination NN cord-010119-t1x9gknd 7878 12 at at IN cord-010119-t1x9gknd 7878 13 IS is NN cord-010119-t1x9gknd 7878 14 , , , cord-010119-t1x9gknd 7878 15 mimicking mimic VBG cord-010119-t1x9gknd 7878 16 reactivity reactivity NN cord-010119-t1x9gknd 7878 17 observed observe VBN cord-010119-t1x9gknd 7878 18 with with IN cord-010119-t1x9gknd 7878 19 IgM IgM NNP cord-010119-t1x9gknd 7878 20 antibodies antibody NNS cord-010119-t1x9gknd 7878 21 although although IN cord-010119-t1x9gknd 7878 22 Hu5F9-G4 Hu5F9-G4 NNP cord-010119-t1x9gknd 7878 23 is be VBZ cord-010119-t1x9gknd 7878 24 IgG4 igg4 PRP cord-010119-t1x9gknd 7878 25 . . . cord-010119-t1x9gknd 7879 1 Reactivity reactivity NN cord-010119-t1x9gknd 7879 2 was be VBD cord-010119-t1x9gknd 7879 3 observed observe VBN cord-010119-t1x9gknd 7879 4 in in IN cord-010119-t1x9gknd 7879 5 all all DT cord-010119-t1x9gknd 7879 6 phases phase NNS cord-010119-t1x9gknd 7879 7 and and CC cord-010119-t1x9gknd 7879 8 with with IN cord-010119-t1x9gknd 7879 9 all all DT cord-010119-t1x9gknd 7879 10 test test NN cord-010119-t1x9gknd 7879 11 methods method NNS cord-010119-t1x9gknd 7879 12 . . . cord-010119-t1x9gknd 7880 1 CD47 CD47 NNP cord-010119-t1x9gknd 7880 2 is be VBZ cord-010119-t1x9gknd 7880 3 not not RB cord-010119-t1x9gknd 7880 4 cleaved cleave VBN cord-010119-t1x9gknd 7880 5 from from IN cord-010119-t1x9gknd 7880 6 RBCs rbc NNS cord-010119-t1x9gknd 7880 7 by by IN cord-010119-t1x9gknd 7880 8 DTT DTT NNP cord-010119-t1x9gknd 7880 9 , , , cord-010119-t1x9gknd 7880 10 trypsin trypsin NN cord-010119-t1x9gknd 7880 11 , , , cord-010119-t1x9gknd 7880 12 papain/ papain/ CD cord-010119-t1x9gknd 7880 13 ficin ficin NNS cord-010119-t1x9gknd 7880 14 , , , cord-010119-t1x9gknd 7880 15 DTT DTT NNP cord-010119-t1x9gknd 7880 16 with with IN cord-010119-t1x9gknd 7880 17 ficin ficin NNS cord-010119-t1x9gknd 7880 18 ( ( -LRB- cord-010119-t1x9gknd 7880 19 W.A.R.M. W.A.R.M. NNP cord-010119-t1x9gknd 7880 20 ) ) -RRB- cord-010119-t1x9gknd 7880 21 or or CC cord-010119-t1x9gknd 7880 22 a a DT cord-010119-t1x9gknd 7880 23 - - HYPH cord-010119-t1x9gknd 7880 24 chymotrypsin chymotrypsin NN cord-010119-t1x9gknd 7880 25 , , , cord-010119-t1x9gknd 7880 26 and and CC cord-010119-t1x9gknd 7880 27 treatment treatment NN cord-010119-t1x9gknd 7880 28 of of IN cord-010119-t1x9gknd 7880 29 RBCs rbc NNS cord-010119-t1x9gknd 7880 30 with with IN cord-010119-t1x9gknd 7880 31 these these DT cord-010119-t1x9gknd 7880 32 does do VBZ cord-010119-t1x9gknd 7880 33 not not RB cord-010119-t1x9gknd 7880 34 mitigate mitigate VB cord-010119-t1x9gknd 7880 35 interference interference NN cord-010119-t1x9gknd 7880 36 . . . cord-010119-t1x9gknd 7881 1 Numerous numerous JJ cord-010119-t1x9gknd 7881 2 adsorptions adsorption NNS cord-010119-t1x9gknd 7881 3 with with IN cord-010119-t1x9gknd 7881 4 papain papain NN cord-010119-t1x9gknd 7881 5 treated treat VBN cord-010119-t1x9gknd 7881 6 rr rr NN cord-010119-t1x9gknd 7881 7 RBCs rbc NNS cord-010119-t1x9gknd 7881 8 were be VBD cord-010119-t1x9gknd 7881 9 required require VBN cord-010119-t1x9gknd 7881 10 to to TO cord-010119-t1x9gknd 7881 11 remove remove VB cord-010119-t1x9gknd 7881 12 anti anti JJ cord-010119-t1x9gknd 7881 13 - - JJ cord-010119-t1x9gknd 7881 14 CD47 cd47 JJ cord-010119-t1x9gknd 7881 15 reactivity reactivity NN cord-010119-t1x9gknd 7881 16 from from IN cord-010119-t1x9gknd 7881 17 plasma plasma NN cord-010119-t1x9gknd 7881 18 . . . cord-010119-t1x9gknd 7882 1 Use use NN cord-010119-t1x9gknd 7882 2 of of IN cord-010119-t1x9gknd 7882 3 Immucor Immucor NNP cord-010119-t1x9gknd 7882 4 Gamma Gamma NNP cord-010119-t1x9gknd 7882 5 - - HYPH cord-010119-t1x9gknd 7882 6 clone clone NN cord-010119-t1x9gknd 7882 7 anti anti JJ cord-010119-t1x9gknd 7882 8 - - JJ cord-010119-t1x9gknd 7882 9 IgG IgG NNP cord-010119-t1x9gknd 7882 10 , , , cord-010119-t1x9gknd 7882 11 which which WDT cord-010119-t1x9gknd 7882 12 does do VBZ cord-010119-t1x9gknd 7882 13 not not RB cord-010119-t1x9gknd 7882 14 detect detect VB cord-010119-t1x9gknd 7882 15 IgG4 igg4 PRP cord-010119-t1x9gknd 7882 16 , , , cord-010119-t1x9gknd 7882 17 can can MD cord-010119-t1x9gknd 7882 18 mitigate mitigate VB cord-010119-t1x9gknd 7882 19 interference interference NN cord-010119-t1x9gknd 7882 20 in in IN cord-010119-t1x9gknd 7882 21 IAT IAT NNP cord-010119-t1x9gknd 7882 22 although although IN cord-010119-t1x9gknd 7882 23 carryover carryover NN cord-010119-t1x9gknd 7882 24 reactivity reactivity NN cord-010119-t1x9gknd 7882 25 may may MD cord-010119-t1x9gknd 7882 26 be be VB cord-010119-t1x9gknd 7882 27 observed observe VBN cord-010119-t1x9gknd 7882 28 . . . cord-010119-t1x9gknd 7883 1 Due due IN cord-010119-t1x9gknd 7883 2 to to IN cord-010119-t1x9gknd 7883 3 blocking block VBG cord-010119-t1x9gknd 7883 4 by by IN cord-010119-t1x9gknd 7883 5 anti anti JJ cord-010119-t1x9gknd 7883 6 - - JJ cord-010119-t1x9gknd 7883 7 CD47 CD47 NNP cord-010119-t1x9gknd 7883 8 on on IN cord-010119-t1x9gknd 7883 9 the the DT cord-010119-t1x9gknd 7883 10 patient patient NN cord-010119-t1x9gknd 7883 11 RBCs rbc NNS cord-010119-t1x9gknd 7883 12 , , , cord-010119-t1x9gknd 7883 13 DAT DAT NNP cord-010119-t1x9gknd 7883 14 and and CC cord-010119-t1x9gknd 7883 15 autocontrols autocontrol NNS cord-010119-t1x9gknd 7883 16 were be VBD cord-010119-t1x9gknd 7883 17 weak weak JJ cord-010119-t1x9gknd 7883 18 or or CC cord-010119-t1x9gknd 7883 19 non non JJ cord-010119-t1x9gknd 7883 20 - - JJ cord-010119-t1x9gknd 7883 21 reactive reactive JJ cord-010119-t1x9gknd 7883 22 ; ; : cord-010119-t1x9gknd 7883 23 however however RB cord-010119-t1x9gknd 7883 24 eluates eluate NNS cord-010119-t1x9gknd 7883 25 prepared prepare VBD cord-010119-t1x9gknd 7883 26 from from IN cord-010119-t1x9gknd 7883 27 the the DT cord-010119-t1x9gknd 7883 28 DAT1 DAT1 NNP cord-010119-t1x9gknd 7883 29 RBCs rbc NNS cord-010119-t1x9gknd 7883 30 were be VBD cord-010119-t1x9gknd 7883 31 strong strong JJ cord-010119-t1x9gknd 7883 32 and and CC cord-010119-t1x9gknd 7883 33 pan pan JJ cord-010119-t1x9gknd 7883 34 - - JJ cord-010119-t1x9gknd 7883 35 reactive reactive JJ cord-010119-t1x9gknd 7883 36 using use VBG cord-010119-t1x9gknd 7883 37 Ortho Ortho NNP cord-010119-t1x9gknd 7883 38 Anti Anti NNP cord-010119-t1x9gknd 7883 39 - - NNP cord-010119-t1x9gknd 7883 40 IgG. IgG. NNP cord-010119-t1x9gknd 7883 41 Background Background NNP cord-010119-t1x9gknd 7883 42 / / SYM cord-010119-t1x9gknd 7883 43 Case Case NNP cord-010119-t1x9gknd 7883 44 Studies Studies NNPS cord-010119-t1x9gknd 7883 45 : : : cord-010119-t1x9gknd 7883 46 A a DT cord-010119-t1x9gknd 7883 47 Caucasian caucasian JJ cord-010119-t1x9gknd 7883 48 woman woman NN cord-010119-t1x9gknd 7883 49 with with IN cord-010119-t1x9gknd 7883 50 history history NN cord-010119-t1x9gknd 7883 51 of of IN cord-010119-t1x9gknd 7883 52 a a DT cord-010119-t1x9gknd 7883 53 Caesarean caesarean JJ cord-010119-t1x9gknd 7883 54 section section NN cord-010119-t1x9gknd 7883 55 and and CC cord-010119-t1x9gknd 7883 56 a a DT cord-010119-t1x9gknd 7883 57 RBC RBC NNP cord-010119-t1x9gknd 7883 58 TX TX NNP cord-010119-t1x9gknd 7883 59 in in IN cord-010119-t1x9gknd 7883 60 1985 1985 CD cord-010119-t1x9gknd 7883 61 . . . cord-010119-t1x9gknd 7884 1 In in IN cord-010119-t1x9gknd 7884 2 August August NNP cord-010119-t1x9gknd 7884 3 2016 2016 CD cord-010119-t1x9gknd 7884 4 , , , cord-010119-t1x9gknd 7884 5 she -PRON- PRP cord-010119-t1x9gknd 7884 6 was be VBD cord-010119-t1x9gknd 7884 7 admitted admit VBN cord-010119-t1x9gknd 7884 8 to to IN cord-010119-t1x9gknd 7884 9 hospital hospital NN cord-010119-t1x9gknd 7884 10 for for IN cord-010119-t1x9gknd 7884 11 trauma trauma NN cord-010119-t1x9gknd 7884 12 surgery surgery NN cord-010119-t1x9gknd 7884 13 , , , cord-010119-t1x9gknd 7884 14 ab ab NN cord-010119-t1x9gknd 7884 15 screening screening NN cord-010119-t1x9gknd 7884 16 was be VBD cord-010119-t1x9gknd 7884 17 negative negative JJ cord-010119-t1x9gknd 7884 18 and and CC cord-010119-t1x9gknd 7884 19 two two CD cord-010119-t1x9gknd 7884 20 units unit NNS cord-010119-t1x9gknd 7884 21 were be VBD cord-010119-t1x9gknd 7884 22 transfused transfuse VBN cord-010119-t1x9gknd 7884 23 without without IN cord-010119-t1x9gknd 7884 24 transfusion transfusion NN cord-010119-t1x9gknd 7884 25 reactions reaction NNS cord-010119-t1x9gknd 7884 26 . . . cord-010119-t1x9gknd 7885 1 Five five CD cord-010119-t1x9gknd 7885 2 days day NNS cord-010119-t1x9gknd 7885 3 later later RBR cord-010119-t1x9gknd 7885 4 she -PRON- PRP cord-010119-t1x9gknd 7885 5 was be VBD cord-010119-t1x9gknd 7885 6 referred refer VBN cord-010119-t1x9gknd 7885 7 to to IN cord-010119-t1x9gknd 7885 8 a a DT cord-010119-t1x9gknd 7885 9 tertiary tertiary JJ cord-010119-t1x9gknd 7885 10 care care NN cord-010119-t1x9gknd 7885 11 trauma trauma NN cord-010119-t1x9gknd 7885 12 center center NN cord-010119-t1x9gknd 7885 13 due due IN cord-010119-t1x9gknd 7885 14 to to IN cord-010119-t1x9gknd 7885 15 a a DT cord-010119-t1x9gknd 7885 16 severe severe JJ cord-010119-t1x9gknd 7885 17 postop postop NN cord-010119-t1x9gknd 7885 18 infection infection NN cord-010119-t1x9gknd 7885 19 and and CC cord-010119-t1x9gknd 7885 20 need need NN cord-010119-t1x9gknd 7885 21 for for IN cord-010119-t1x9gknd 7885 22 a a DT cord-010119-t1x9gknd 7885 23 reoperation reoperation NN cord-010119-t1x9gknd 7885 24 . . . cord-010119-t1x9gknd 7886 1 Ab ab NN cord-010119-t1x9gknd 7886 2 screening screening NN cord-010119-t1x9gknd 7886 3 was be VBD cord-010119-t1x9gknd 7886 4 now now RB cord-010119-t1x9gknd 7886 5 positive positive JJ cord-010119-t1x9gknd 7886 6 , , , cord-010119-t1x9gknd 7886 7 with with IN cord-010119-t1x9gknd 7886 8 an an DT cord-010119-t1x9gknd 7886 9 antibody antibody NN cord-010119-t1x9gknd 7886 10 reacting react VBG cord-010119-t1x9gknd 7886 11 with with IN cord-010119-t1x9gknd 7886 12 all all DT cord-010119-t1x9gknd 7886 13 panel panel NN cord-010119-t1x9gknd 7886 14 cells cell NNS cord-010119-t1x9gknd 7886 15 detected detect VBD cord-010119-t1x9gknd 7886 16 . . . cord-010119-t1x9gknd 7887 1 Because because IN cord-010119-t1x9gknd 7887 2 of of IN cord-010119-t1x9gknd 7887 3 the the DT cord-010119-t1x9gknd 7887 4 urgent urgent JJ cord-010119-t1x9gknd 7887 5 need need NN cord-010119-t1x9gknd 7887 6 for for IN cord-010119-t1x9gknd 7887 7 RBC RBC NNP cord-010119-t1x9gknd 7887 8 TX TX NNP cord-010119-t1x9gknd 7887 9 , , , cord-010119-t1x9gknd 7887 10 two two CD cord-010119-t1x9gknd 7887 11 weakly weakly RB cord-010119-t1x9gknd 7887 12 cross cross JJ cord-010119-t1x9gknd 7887 13 - - JJ cord-010119-t1x9gknd 7887 14 match match VB cord-010119-t1x9gknd 7887 15 positive positive JJ cord-010119-t1x9gknd 7887 16 Rh1 rh1 NN cord-010119-t1x9gknd 7888 1 K K NNP cord-010119-t1x9gknd 7888 2 matched match VBD cord-010119-t1x9gknd 7888 3 units unit NNS cord-010119-t1x9gknd 7888 4 were be VBD cord-010119-t1x9gknd 7888 5 transfused transfuse VBN cord-010119-t1x9gknd 7888 6 with with IN cord-010119-t1x9gknd 7888 7 a a DT cord-010119-t1x9gknd 7888 8 warning warning NN cord-010119-t1x9gknd 7888 9 of of IN cord-010119-t1x9gknd 7888 10 possible possible JJ cord-010119-t1x9gknd 7888 11 alloantibodies alloantibody NNS cord-010119-t1x9gknd 7888 12 . . . cord-010119-t1x9gknd 7889 1 The the DT cord-010119-t1x9gknd 7889 2 patient patient NN cord-010119-t1x9gknd 7889 3 got get VBD cord-010119-t1x9gknd 7889 4 acute acute JJ cord-010119-t1x9gknd 7889 5 hemolysis hemolysis NN cord-010119-t1x9gknd 7889 6 . . . cord-010119-t1x9gknd 7890 1 Study Study NNP cord-010119-t1x9gknd 7890 2 Design Design NNP cord-010119-t1x9gknd 7890 3 / / SYM cord-010119-t1x9gknd 7890 4 Method method NN cord-010119-t1x9gknd 7890 5 : : : cord-010119-t1x9gknd 7891 1 A a DT cord-010119-t1x9gknd 7891 2 Gel gel NN cord-010119-t1x9gknd 7891 3 technique technique NN cord-010119-t1x9gknd 7891 4 was be VBD cord-010119-t1x9gknd 7891 5 used use VBN cord-010119-t1x9gknd 7891 6 in in IN cord-010119-t1x9gknd 7891 7 the the DT cord-010119-t1x9gknd 7891 8 Hospital Hospital NNP cord-010119-t1x9gknd 7891 9 Transfusion Transfusion NNP cord-010119-t1x9gknd 7891 10 Laboratory Laboratory NNP cord-010119-t1x9gknd 7891 11 . . . cord-010119-t1x9gknd 7892 1 In in IN cord-010119-t1x9gknd 7892 2 addition addition NN cord-010119-t1x9gknd 7892 3 , , , cord-010119-t1x9gknd 7892 4 various various JJ cord-010119-t1x9gknd 7892 5 antibody antibody NN cord-010119-t1x9gknd 7892 6 identification identification NN cord-010119-t1x9gknd 7892 7 panels panel NNS cord-010119-t1x9gknd 7892 8 and and CC cord-010119-t1x9gknd 7892 9 special special JJ cord-010119-t1x9gknd 7892 10 serological serological JJ cord-010119-t1x9gknd 7892 11 and and CC cord-010119-t1x9gknd 7892 12 genotyping genotyping NN cord-010119-t1x9gknd 7892 13 methods method NNS cord-010119-t1x9gknd 7892 14 were be VBD cord-010119-t1x9gknd 7892 15 used use VBN cord-010119-t1x9gknd 7892 16 in in IN cord-010119-t1x9gknd 7892 17 the the DT cord-010119-t1x9gknd 7892 18 Reference Reference NNP cord-010119-t1x9gknd 7892 19 Laboratory Laboratory NNP cord-010119-t1x9gknd 7892 20 . . . cord-010119-t1x9gknd 7893 1 KEL KEL NNP cord-010119-t1x9gknd 7893 2 sequencing sequencing NN cord-010119-t1x9gknd 7893 3 was be VBD cord-010119-t1x9gknd 7893 4 done do VBN cord-010119-t1x9gknd 7893 5 by by IN cord-010119-t1x9gknd 7893 6 the the DT cord-010119-t1x9gknd 7893 7 International International NNP cord-010119-t1x9gknd 7893 8 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 7893 9 Center Center NNP cord-010119-t1x9gknd 7893 10 . . . cord-010119-t1x9gknd 7894 1 Results/ Results/ . cord-010119-t1x9gknd 7895 1 Finding find VBG cord-010119-t1x9gknd 7895 2 : : : cord-010119-t1x9gknd 7895 3 The the DT cord-010119-t1x9gknd 7895 4 Hospital Hospital NNP cord-010119-t1x9gknd 7895 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 7895 6 Laboratory Laboratory NNP cord-010119-t1x9gknd 7895 7 results result NNS cord-010119-t1x9gknd 7895 8 were be VBD cord-010119-t1x9gknd 7895 9 O o UH cord-010119-t1x9gknd 7896 1 RhD RhD NNP cord-010119-t1x9gknd 7896 2 neg neg NNP cord-010119-t1x9gknd 7896 3 , , , cord-010119-t1x9gknd 7896 4 DAT DAT NNP cord-010119-t1x9gknd 7896 5 neg neg JJ cord-010119-t1x9gknd 7896 6 , , , cord-010119-t1x9gknd 7896 7 and and CC cord-010119-t1x9gknd 7896 8 the the DT cord-010119-t1x9gknd 7896 9 ab ab NN cord-010119-t1x9gknd 7896 10 identification identification NN cord-010119-t1x9gknd 7896 11 was be VBD cord-010119-t1x9gknd 7896 12 21 21 CD cord-010119-t1x9gknd 7896 13 with with IN cord-010119-t1x9gknd 7896 14 untreated untreated JJ cord-010119-t1x9gknd 7896 15 and and CC cord-010119-t1x9gknd 7896 16 31 31 CD cord-010119-t1x9gknd 7896 17 with with IN cord-010119-t1x9gknd 7896 18 enzyme enzyme NN cord-010119-t1x9gknd 7896 19 - - HYPH cord-010119-t1x9gknd 7896 20 treated treat VBN cord-010119-t1x9gknd 7896 21 cells cell NNS cord-010119-t1x9gknd 7896 22 , , , cord-010119-t1x9gknd 7896 23 with with IN cord-010119-t1x9gknd 7896 24 weakly weakly RB cord-010119-t1x9gknd 7896 25 positive positive JJ cord-010119-t1x9gknd 7896 26 autocontrols autocontrol NNS cord-010119-t1x9gknd 7896 27 . . . cord-010119-t1x9gknd 7897 1 A a DT cord-010119-t1x9gknd 7897 2 sample sample NN cord-010119-t1x9gknd 7897 3 was be VBD cord-010119-t1x9gknd 7897 4 submitted submit VBN cord-010119-t1x9gknd 7897 5 to to IN cord-010119-t1x9gknd 7897 6 the the DT cord-010119-t1x9gknd 7897 7 reference reference NN cord-010119-t1x9gknd 7897 8 laboratory laboratory NN cord-010119-t1x9gknd 7897 9 for for IN cord-010119-t1x9gknd 7897 10 additional additional JJ cord-010119-t1x9gknd 7897 11 investigation investigation NN cord-010119-t1x9gknd 7897 12 . . . cord-010119-t1x9gknd 7898 1 DAT DAT NNP cord-010119-t1x9gknd 7898 2 was be VBD cord-010119-t1x9gknd 7898 3 weakly weakly RB cord-010119-t1x9gknd 7898 4 positive positive JJ cord-010119-t1x9gknd 7898 5 , , , cord-010119-t1x9gknd 7898 6 while while IN cord-010119-t1x9gknd 7898 7 ab ab NN cord-010119-t1x9gknd 7898 8 identification identification NN cord-010119-t1x9gknd 7898 9 results result NNS cord-010119-t1x9gknd 7898 10 were be VBD cord-010119-t1x9gknd 7898 11 similar similar JJ cord-010119-t1x9gknd 7898 12 to to IN cord-010119-t1x9gknd 7898 13 the the DT cord-010119-t1x9gknd 7898 14 hospital hospital NN cord-010119-t1x9gknd 7898 15 results result NNS cord-010119-t1x9gknd 7898 16 . . . cord-010119-t1x9gknd 7899 1 Different different JJ cord-010119-t1x9gknd 7899 2 pheno pheno NN cord-010119-t1x9gknd 7899 3 - - HYPH cord-010119-t1x9gknd 7899 4 and and CC cord-010119-t1x9gknd 7899 5 genotyping genotyping NN cord-010119-t1x9gknd 7899 6 methods method NNS cord-010119-t1x9gknd 7899 7 were be VBD cord-010119-t1x9gknd 7899 8 used use VBN cord-010119-t1x9gknd 7899 9 in in IN cord-010119-t1x9gknd 7899 10 addition addition NN cord-010119-t1x9gknd 7899 11 to to IN cord-010119-t1x9gknd 7899 12 several several JJ cord-010119-t1x9gknd 7899 13 identification identification NN cord-010119-t1x9gknd 7899 14 panels panel NNS cord-010119-t1x9gknd 7899 15 to to TO cord-010119-t1x9gknd 7899 16 exclude exclude VB cord-010119-t1x9gknd 7899 17 rare rare JJ cord-010119-t1x9gknd 7899 18 blood blood NN cord-010119-t1x9gknd 7899 19 groups group NNS cord-010119-t1x9gknd 7899 20 . . . cord-010119-t1x9gknd 7900 1 After after IN cord-010119-t1x9gknd 7900 2 Pk Pk NNP cord-010119-t1x9gknd 7900 3 , , , cord-010119-t1x9gknd 7900 4 Vel Vel NNP cord-010119-t1x9gknd 7900 5 neg neg NNP cord-010119-t1x9gknd 7900 6 , , , cord-010119-t1x9gknd 7900 7 Jk:-3 Jk:-3 '' cord-010119-t1x9gknd 7900 8 etc etc FW cord-010119-t1x9gknd 7900 9 . . NN cord-010119-t1x9gknd 7900 10 had have VBD cord-010119-t1x9gknd 7900 11 been be VBN cord-010119-t1x9gknd 7900 12 excluded exclude VBN cord-010119-t1x9gknd 7900 13 , , , cord-010119-t1x9gknd 7900 14 k k NN cord-010119-t1x9gknd 7900 15 - - HYPH cord-010119-t1x9gknd 7900 16 phenotyping phenotyping NN cord-010119-t1x9gknd 7900 17 revealed reveal VBD cord-010119-t1x9gknd 7900 18 a a DT cord-010119-t1x9gknd 7900 19 K k NN cord-010119-t1x9gknd 7900 20 0 0 CD cord-010119-t1x9gknd 7900 21 -phenotype -phenotype CD cord-010119-t1x9gknd 7900 22 . . . cord-010119-t1x9gknd 7901 1 A a DT cord-010119-t1x9gknd 7901 2 total total NN cord-010119-t1x9gknd 7901 3 of of IN cord-010119-t1x9gknd 7901 4 38 38 CD cord-010119-t1x9gknd 7901 5 silencing silencing NN cord-010119-t1x9gknd 7901 6 mutations mutation NNS cord-010119-t1x9gknd 7901 7 are be VBP cord-010119-t1x9gknd 7901 8 known know VBN cord-010119-t1x9gknd 7901 9 for for IN cord-010119-t1x9gknd 7901 10 the the DT cord-010119-t1x9gknd 7901 11 KEL KEL NNP cord-010119-t1x9gknd 7901 12 gene gene NN cord-010119-t1x9gknd 7901 13 and and CC cord-010119-t1x9gknd 7901 14 the the DT cord-010119-t1x9gknd 7901 15 genotyping genotyping NN cord-010119-t1x9gknd 7901 16 kits kit NNS cord-010119-t1x9gknd 7901 17 used use VBN cord-010119-t1x9gknd 7901 18 did do VBD cord-010119-t1x9gknd 7901 19 not not RB cord-010119-t1x9gknd 7901 20 recognize recognize VB cord-010119-t1x9gknd 7901 21 these these DT cord-010119-t1x9gknd 7901 22 . . . cord-010119-t1x9gknd 7902 1 The the DT cord-010119-t1x9gknd 7902 2 Anti Anti NNP cord-010119-t1x9gknd 7902 3 - - NNP cord-010119-t1x9gknd 7902 4 Ku Ku NNP cord-010119-t1x9gknd 7902 5 antibody antibody NN cord-010119-t1x9gknd 7902 6 reacts react VBZ cord-010119-t1x9gknd 7902 7 with with IN cord-010119-t1x9gknd 7902 8 all all DT cord-010119-t1x9gknd 7902 9 cells cell NNS cord-010119-t1x9gknd 7902 10 apart apart RB cord-010119-t1x9gknd 7902 11 from from IN cord-010119-t1x9gknd 7902 12 the the DT cord-010119-t1x9gknd 7902 13 K K NNP cord-010119-t1x9gknd 7902 14 0 0 CD cord-010119-t1x9gknd 7902 15 -phenotype -phenotype CD cord-010119-t1x9gknd 7902 16 . . . cord-010119-t1x9gknd 7903 1 The the DT cord-010119-t1x9gknd 7903 2 presence presence NN cord-010119-t1x9gknd 7903 3 of of IN cord-010119-t1x9gknd 7903 4 DTT DTT NNP cord-010119-t1x9gknd 7903 5 - - HYPH cord-010119-t1x9gknd 7903 6 sensitive sensitive JJ cord-010119-t1x9gknd 7903 7 anti anti NNP cord-010119-t1x9gknd 7903 8 - - NNP cord-010119-t1x9gknd 7903 9 Ku Ku NNP cord-010119-t1x9gknd 7903 10 was be VBD cord-010119-t1x9gknd 7903 11 confirmed confirm VBN cord-010119-t1x9gknd 7903 12 with with IN cord-010119-t1x9gknd 7903 13 DTT DTT NNP cord-010119-t1x9gknd 7903 14 - - HYPH cord-010119-t1x9gknd 7903 15 treated treat VBN cord-010119-t1x9gknd 7903 16 panel panel NN cord-010119-t1x9gknd 7903 17 cells cell NNS cord-010119-t1x9gknd 7903 18 . . . cord-010119-t1x9gknd 7904 1 Anti Anti NNP cord-010119-t1x9gknd 7904 2 - - NNP cord-010119-t1x9gknd 7904 3 Ku Ku NNP cord-010119-t1x9gknd 7904 4 may may MD cord-010119-t1x9gknd 7904 5 cause cause VB cord-010119-t1x9gknd 7904 6 immediate immediate JJ cord-010119-t1x9gknd 7904 7 and and CC cord-010119-t1x9gknd 7904 8 delayed delayed JJ cord-010119-t1x9gknd 7904 9 hemolytic hemolytic JJ cord-010119-t1x9gknd 7904 10 transfusion transfusion NN cord-010119-t1x9gknd 7904 11 reactions reaction NNS cord-010119-t1x9gknd 7904 12 . . . cord-010119-t1x9gknd 7905 1 Samples sample NNS cord-010119-t1x9gknd 7905 2 were be VBD cord-010119-t1x9gknd 7905 3 taken take VBN cord-010119-t1x9gknd 7905 4 from from IN cord-010119-t1x9gknd 7905 5 the the DT cord-010119-t1x9gknd 7905 6 patient patient NN cord-010119-t1x9gknd 7905 7 's 's POS cord-010119-t1x9gknd 7905 8 two two CD cord-010119-t1x9gknd 7905 9 siblings sibling NNS cord-010119-t1x9gknd 7905 10 and and CC cord-010119-t1x9gknd 7905 11 daughter daughter NN cord-010119-t1x9gknd 7905 12 . . . cord-010119-t1x9gknd 7906 1 KEL KEL NNP cord-010119-t1x9gknd 7906 2 sequencing sequencing NN cord-010119-t1x9gknd 7906 3 revealed reveal VBD cord-010119-t1x9gknd 7906 4 KEL*02N.19 KEL*02N.19 NNP cord-010119-t1x9gknd 7906 5 with with IN cord-010119-t1x9gknd 7906 6 c.2023 c.2023 NNP cord-010119-t1x9gknd 7906 7 T T NNP cord-010119-t1x9gknd 7906 8 encoding encoding NN cord-010119-t1x9gknd 7906 9 p.675Ter p.675Ter NNP cord-010119-t1x9gknd 7906 10 ( ( -LRB- cord-010119-t1x9gknd 7906 11 reported report VBN cord-010119-t1x9gknd 7906 12 in in IN cord-010119-t1x9gknd 7906 13 an an DT cord-010119-t1x9gknd 7906 14 individual individual NN cord-010119-t1x9gknd 7906 15 from from IN cord-010119-t1x9gknd 7906 16 Austria Austria NNP cord-010119-t1x9gknd 7906 17 in in IN cord-010119-t1x9gknd 7906 18 2007 2007 CD cord-010119-t1x9gknd 7906 19 ) ) -RRB- cord-010119-t1x9gknd 7906 20 . . . cord-010119-t1x9gknd 7907 1 There there EX cord-010119-t1x9gknd 7907 2 are be VBP cord-010119-t1x9gknd 7907 3 two two CD cord-010119-t1x9gknd 7907 4 known know VBN cord-010119-t1x9gknd 7907 5 K k NN cord-010119-t1x9gknd 7907 6 0 0 CD cord-010119-t1x9gknd 7907 7 -patients -patient NNS cord-010119-t1x9gknd 7907 8 in in IN cord-010119-t1x9gknd 7907 9 our -PRON- PRP$ cord-010119-t1x9gknd 7907 10 country country NN cord-010119-t1x9gknd 7907 11 , , , cord-010119-t1x9gknd 7907 12 both both DT cord-010119-t1x9gknd 7907 13 homozygous homozygous JJ cord-010119-t1x9gknd 7907 14 for for IN cord-010119-t1x9gknd 7907 15 c.2023T. c.2023T. NNP cord-010119-t1x9gknd 7908 1 The the DT cord-010119-t1x9gknd 7908 2 daughter daughter NN cord-010119-t1x9gknd 7908 3 was be VBD cord-010119-t1x9gknd 7908 4 a a DT cord-010119-t1x9gknd 7908 5 c.2023 c.2023 NNP cord-010119-t1x9gknd 7908 6 T T NNP cord-010119-t1x9gknd 7908 7 heterozygote heterozygote NN cord-010119-t1x9gknd 7908 8 , , , cord-010119-t1x9gknd 7908 9 while while IN cord-010119-t1x9gknd 7908 10 the the DT cord-010119-t1x9gknd 7908 11 siblings sibling NNS cord-010119-t1x9gknd 7908 12 did do VBD cord-010119-t1x9gknd 7908 13 not not RB cord-010119-t1x9gknd 7908 14 have have VB cord-010119-t1x9gknd 7908 15 this this DT cord-010119-t1x9gknd 7908 16 variant variant NN cord-010119-t1x9gknd 7908 17 . . . cord-010119-t1x9gknd 7909 1 A a DT cord-010119-t1x9gknd 7909 2 new new JJ cord-010119-t1x9gknd 7909 3 operation operation NN cord-010119-t1x9gknd 7909 4 is be VBZ cord-010119-t1x9gknd 7909 5 necessary necessary JJ cord-010119-t1x9gknd 7909 6 but but CC cord-010119-t1x9gknd 7909 7 no no DT cord-010119-t1x9gknd 7909 8 K k NN cord-010119-t1x9gknd 7909 9 0 0 CD cord-010119-t1x9gknd 7909 10 -donors -donors : cord-010119-t1x9gknd 7909 11 are be VBP cord-010119-t1x9gknd 7909 12 available available JJ cord-010119-t1x9gknd 7909 13 in in IN cord-010119-t1x9gknd 7909 14 our -PRON- PRP$ cord-010119-t1x9gknd 7909 15 country country NN cord-010119-t1x9gknd 7909 16 . . . cord-010119-t1x9gknd 7910 1 With with IN cord-010119-t1x9gknd 7910 2 the the DT cord-010119-t1x9gknd 7910 3 help help NN cord-010119-t1x9gknd 7910 4 of of IN cord-010119-t1x9gknd 7910 5 the the DT cord-010119-t1x9gknd 7910 6 ISBT ISBT NNP cord-010119-t1x9gknd 7910 7 Rare Rare NNP cord-010119-t1x9gknd 7910 8 Donor Donor NNP cord-010119-t1x9gknd 7910 9 Working Working NNP cord-010119-t1x9gknd 7910 10 Party Party NNP cord-010119-t1x9gknd 7910 11 , , , cord-010119-t1x9gknd 7910 12 a a DT cord-010119-t1x9gknd 7910 13 K k NN cord-010119-t1x9gknd 7910 14 0 0 CD cord-010119-t1x9gknd 7910 15 O o NN cord-010119-t1x9gknd 7910 16 RhD rhd NN cord-010119-t1x9gknd 7910 17 neg neg NNP cord-010119-t1x9gknd 7910 18 donor donor NN cord-010119-t1x9gknd 7910 19 was be VBD cord-010119-t1x9gknd 7910 20 found find VBN cord-010119-t1x9gknd 7910 21 in in IN cord-010119-t1x9gknd 7910 22 Japan Japan NNP cord-010119-t1x9gknd 7910 23 and and CC cord-010119-t1x9gknd 7910 24 one one CD cord-010119-t1x9gknd 7910 25 unit unit NN cord-010119-t1x9gknd 7910 26 was be VBD cord-010119-t1x9gknd 7910 27 delivered deliver VBN cord-010119-t1x9gknd 7910 28 to to IN cord-010119-t1x9gknd 7910 29 us -PRON- PRP cord-010119-t1x9gknd 7910 30 for for IN cord-010119-t1x9gknd 7910 31 use use NN cord-010119-t1x9gknd 7910 32 in in IN cord-010119-t1x9gknd 7910 33 the the DT cord-010119-t1x9gknd 7910 34 next next JJ cord-010119-t1x9gknd 7910 35 operation operation NN cord-010119-t1x9gknd 7910 36 . . . cord-010119-t1x9gknd 7911 1 Conclusion conclusion NN cord-010119-t1x9gknd 7911 2 : : : cord-010119-t1x9gknd 7912 1 An an DT cord-010119-t1x9gknd 7912 2 alloantibody alloantibody NN cord-010119-t1x9gknd 7912 3 should should MD cord-010119-t1x9gknd 7912 4 always always RB cord-010119-t1x9gknd 7912 5 be be VB cord-010119-t1x9gknd 7912 6 suspected suspect VBN cord-010119-t1x9gknd 7912 7 when when WRB cord-010119-t1x9gknd 7912 8 autocontrol autocontrol NNP cord-010119-t1x9gknd 7912 9 is be VBZ cord-010119-t1x9gknd 7912 10 weaker weak JJR cord-010119-t1x9gknd 7912 11 than than IN cord-010119-t1x9gknd 7912 12 panel panel NN cord-010119-t1x9gknd 7912 13 cell cell NN cord-010119-t1x9gknd 7912 14 reactions reaction NNS cord-010119-t1x9gknd 7912 15 , , , cord-010119-t1x9gknd 7912 16 even even RB cord-010119-t1x9gknd 7912 17 if if IN cord-010119-t1x9gknd 7912 18 the the DT cord-010119-t1x9gknd 7912 19 direct direct JJ cord-010119-t1x9gknd 7912 20 Coombs Coombs NNP cord-010119-t1x9gknd 7912 21 is be VBZ cord-010119-t1x9gknd 7912 22 positive positive JJ cord-010119-t1x9gknd 7912 23 . . . cord-010119-t1x9gknd 7913 1 A a DT cord-010119-t1x9gknd 7913 2 combined combined JJ cord-010119-t1x9gknd 7913 3 serological serological JJ cord-010119-t1x9gknd 7913 4 and and CC cord-010119-t1x9gknd 7913 5 genotyping genotyping NN cord-010119-t1x9gknd 7913 6 approach approach NN cord-010119-t1x9gknd 7913 7 offers offer VBZ cord-010119-t1x9gknd 7913 8 the the DT cord-010119-t1x9gknd 7913 9 best good JJS cord-010119-t1x9gknd 7913 10 solution solution NN cord-010119-t1x9gknd 7913 11 for for IN cord-010119-t1x9gknd 7913 12 problematic problematic JJ cord-010119-t1x9gknd 7913 13 antibody antibody NN cord-010119-t1x9gknd 7913 14 cases case NNS cord-010119-t1x9gknd 7913 15 . . . cord-010119-t1x9gknd 7914 1 Compatible compatible JJ cord-010119-t1x9gknd 7914 2 blood blood NN cord-010119-t1x9gknd 7914 3 is be VBZ cord-010119-t1x9gknd 7914 4 not not RB cord-010119-t1x9gknd 7914 5 always always RB cord-010119-t1x9gknd 7914 6 available available JJ cord-010119-t1x9gknd 7914 7 in in IN cord-010119-t1x9gknd 7914 8 rare rare JJ cord-010119-t1x9gknd 7914 9 blood blood NN cord-010119-t1x9gknd 7914 10 group group NN cord-010119-t1x9gknd 7914 11 cases case NNS cord-010119-t1x9gknd 7914 12 , , , cord-010119-t1x9gknd 7914 13 but but CC cord-010119-t1x9gknd 7914 14 international international JJ cord-010119-t1x9gknd 7914 15 co co NN cord-010119-t1x9gknd 7914 16 - - NN cord-010119-t1x9gknd 7914 17 operation operation NN cord-010119-t1x9gknd 7914 18 may may MD cord-010119-t1x9gknd 7914 19 be be VB cord-010119-t1x9gknd 7914 20 of of IN cord-010119-t1x9gknd 7914 21 help help NN cord-010119-t1x9gknd 7914 22 in in IN cord-010119-t1x9gknd 7914 23 finding find VBG cord-010119-t1x9gknd 7914 24 a a DT cord-010119-t1x9gknd 7914 25 suitable suitable JJ cord-010119-t1x9gknd 7914 26 donor donor NN cord-010119-t1x9gknd 7914 27 . . . cord-010119-t1x9gknd 7915 1 Transfusion Transfusion NNP cord-010119-t1x9gknd 7915 2 Strategy Strategy NNP cord-010119-t1x9gknd 7915 3 for for IN cord-010119-t1x9gknd 7915 4 the the DT cord-010119-t1x9gknd 7915 5 Serologic Serologic NNP cord-010119-t1x9gknd 7915 6 Weak Weak NNP cord-010119-t1x9gknd 7915 7 D D NNP cord-010119-t1x9gknd 7915 8 Phenotype Phenotype NNP cord-010119-t1x9gknd 7915 9 in in IN cord-010119-t1x9gknd 7915 10 Tunisia Tunisia NNP cord-010119-t1x9gknd 7916 1 Based base VBN cord-010119-t1x9gknd 7916 2 on on IN cord-010119-t1x9gknd 7916 3 RHD RHD NNP cord-010119-t1x9gknd 7916 4 alleles allele NNS cord-010119-t1x9gknd 7916 5 and and CC cord-010119-t1x9gknd 7916 6 RH RH NNP cord-010119-t1x9gknd 7916 7 haplotypes haplotype NNS cord-010119-t1x9gknd 7916 8 Mouna Mouna NNP cord-010119-t1x9gknd 7916 9 Ouchari Ouchari NNP cord-010119-t1x9gknd 7916 10 * * NFP cord-010119-t1x9gknd 7916 11 1 1 CD cord-010119-t1x9gknd 7916 12 , , , cord-010119-t1x9gknd 7916 13 Kshitij Kshitij NNP cord-010119-t1x9gknd 7916 14 Srivastava Srivastava NNP cord-010119-t1x9gknd 7916 15 2 2 CD cord-010119-t1x9gknd 7916 16 , , , cord-010119-t1x9gknd 7916 17 Houda Houda NNP cord-010119-t1x9gknd 7916 18 Romdhane Romdhane NNP cord-010119-t1x9gknd 7916 19 3 3 CD cord-010119-t1x9gknd 7916 20 , , , cord-010119-t1x9gknd 7916 21 Saloua Saloua NNP cord-010119-t1x9gknd 7916 22 Jemni Jemni NNP cord-010119-t1x9gknd 7916 23 Yacoub Yacoub NNP cord-010119-t1x9gknd 7916 24 4 4 CD cord-010119-t1x9gknd 7916 25 and and CC cord-010119-t1x9gknd 7916 26 Willy Willy NNP cord-010119-t1x9gknd 7916 27 Albert Albert NNP cord-010119-t1x9gknd 7916 28 Flegel Flegel NNP cord-010119-t1x9gknd 7916 29 1 1 CD cord-010119-t1x9gknd 7916 30 . . . cord-010119-t1x9gknd 7916 31 1 1 CD cord-010119-t1x9gknd 7916 32 NIH NIH NNP cord-010119-t1x9gknd 7916 33 , , , cord-010119-t1x9gknd 7916 34 2 2 CD cord-010119-t1x9gknd 7916 35 DTM DTM NNP cord-010119-t1x9gknd 7916 36 / / SYM cord-010119-t1x9gknd 7916 37 CC CC NNP cord-010119-t1x9gknd 7916 38 / / SYM cord-010119-t1x9gknd 7916 39 NIH NIH NNP cord-010119-t1x9gknd 7916 40 , , , cord-010119-t1x9gknd 7916 41 3 3 CD cord-010119-t1x9gknd 7916 42 Regional Regional NNP cord-010119-t1x9gknd 7916 43 Blood Blood NNP cord-010119-t1x9gknd 7916 44 Transfusion Transfusion NNP cord-010119-t1x9gknd 7916 45 Center Center NNP cord-010119-t1x9gknd 7916 46 Sousse Sousse NNP cord-010119-t1x9gknd 7916 47 , , , cord-010119-t1x9gknd 7916 48 4 4 CD cord-010119-t1x9gknd 7916 49 Regional Regional NNP cord-010119-t1x9gknd 7916 50 Blood Blood NNP cord-010119-t1x9gknd 7916 51 Transfusion Transfusion NNP cord-010119-t1x9gknd 7916 52 Center Center NNP cord-010119-t1x9gknd 7916 53 Sousse Sousse NNP cord-010119-t1x9gknd 7916 54 , , , cord-010119-t1x9gknd 7916 55 Tunisia Tunisia NNP cord-010119-t1x9gknd 7916 56 Background Background NNP cord-010119-t1x9gknd 7916 57 / / SYM cord-010119-t1x9gknd 7916 58 Case Case NNP cord-010119-t1x9gknd 7916 59 Studies Studies NNPS cord-010119-t1x9gknd 7916 60 : : : cord-010119-t1x9gknd 7916 61 D D NNP cord-010119-t1x9gknd 7916 62 antigen antigen NN cord-010119-t1x9gknd 7916 63 variants variant NNS cord-010119-t1x9gknd 7916 64 have have VBP cord-010119-t1x9gknd 7916 65 been be VBN cord-010119-t1x9gknd 7916 66 studied study VBN cord-010119-t1x9gknd 7916 67 molecularly molecularly RB cord-010119-t1x9gknd 7916 68 in in IN cord-010119-t1x9gknd 7916 69 many many JJ cord-010119-t1x9gknd 7916 70 Arab arab JJ cord-010119-t1x9gknd 7916 71 populations population NNS cord-010119-t1x9gknd 7916 72 , , , cord-010119-t1x9gknd 7916 73 including include VBG cord-010119-t1x9gknd 7916 74 Gaza Gaza NNP cord-010119-t1x9gknd 7916 75 , , , cord-010119-t1x9gknd 7916 76 Tunisia Tunisia NNP cord-010119-t1x9gknd 7916 77 , , , cord-010119-t1x9gknd 7916 78 Egypt Egypt NNP cord-010119-t1x9gknd 7916 79 and and CC cord-010119-t1x9gknd 7916 80 Libya Libya NNP cord-010119-t1x9gknd 7916 81 , , , cord-010119-t1x9gknd 7916 82 159A 159a CD cord-010119-t1x9gknd 7916 83 TRANSFUSION transfusion NN cord-010119-t1x9gknd 7916 84 2017 2017 CD cord-010119-t1x9gknd 7916 85 Vol Vol NNP cord-010119-t1x9gknd 7916 86 . . . cord-010119-t1x9gknd 7917 1 57 57 CD cord-010119-t1x9gknd 7917 2 Supplement Supplement NNP cord-010119-t1x9gknd 7917 3 S3 S3 NNP cord-010119-t1x9gknd 7917 4 since since IN cord-010119-t1x9gknd 7917 5 2009 2009 CD cord-010119-t1x9gknd 7917 6 . . . cord-010119-t1x9gknd 7918 1 The the DT cord-010119-t1x9gknd 7918 2 Tunisian tunisian JJ cord-010119-t1x9gknd 7918 3 population population NN cord-010119-t1x9gknd 7918 4 has have VBZ cord-010119-t1x9gknd 7918 5 the the DT cord-010119-t1x9gknd 7918 6 largest large JJS cord-010119-t1x9gknd 7918 7 known know VBN cord-010119-t1x9gknd 7918 8 prevalence prevalence NN cord-010119-t1x9gknd 7918 9 of of IN cord-010119-t1x9gknd 7918 10 weak weak JJ cord-010119-t1x9gknd 7918 11 D d NN cord-010119-t1x9gknd 7918 12 type type NN cord-010119-t1x9gknd 7918 13 4.0 4.0 CD cord-010119-t1x9gknd 7918 14 alleles allele NNS cord-010119-t1x9gknd 7918 15 , , , cord-010119-t1x9gknd 7918 16 occurring occur VBG cord-010119-t1x9gknd 7918 17 in in IN cord-010119-t1x9gknd 7918 18 1 1 CD cord-010119-t1x9gknd 7918 19 of of IN cord-010119-t1x9gknd 7918 20 105 105 CD cord-010119-t1x9gknd 7918 21 RH RH NNP cord-010119-t1x9gknd 7918 22 haplotypes haplotype NNS cord-010119-t1x9gknd 7918 23 , , , cord-010119-t1x9gknd 7918 24 compared compare VBN cord-010119-t1x9gknd 7918 25 to to IN cord-010119-t1x9gknd 7918 26 1 1 CD cord-010119-t1x9gknd 7918 27 in in IN cord-010119-t1x9gknd 7918 28 6,060 6,060 CD cord-010119-t1x9gknd 7918 29 or or CC cord-010119-t1x9gknd 7918 30 less less JJR cord-010119-t1x9gknd 7918 31 in in IN cord-010119-t1x9gknd 7918 32 Europe Europe NNP cord-010119-t1x9gknd 7918 33 . . . cord-010119-t1x9gknd 7919 1 A a DT cord-010119-t1x9gknd 7919 2 systematic systematic JJ cord-010119-t1x9gknd 7919 3 study study NN cord-010119-t1x9gknd 7919 4 was be VBD cord-010119-t1x9gknd 7919 5 missing miss VBG cord-010119-t1x9gknd 7919 6 for for IN cord-010119-t1x9gknd 7919 7 samples sample NNS cord-010119-t1x9gknd 7919 8 with with IN cord-010119-t1x9gknd 7919 9 the the DT cord-010119-t1x9gknd 7919 10 serologic serologic JJ cord-010119-t1x9gknd 7919 11 weak weak JJ cord-010119-t1x9gknd 7919 12 D D NNP cord-010119-t1x9gknd 7919 13 phenotype phenotype NN cord-010119-t1x9gknd 7919 14 routinely routinely RB cord-010119-t1x9gknd 7919 15 found find VBD cord-010119-t1x9gknd 7919 16 in in IN cord-010119-t1x9gknd 7919 17 blood blood NN cord-010119-t1x9gknd 7919 18 donor donor NN cord-010119-t1x9gknd 7919 19 and and CC cord-010119-t1x9gknd 7919 20 patient patient JJ cord-010119-t1x9gknd 7919 21 testing testing NN cord-010119-t1x9gknd 7919 22 in in IN cord-010119-t1x9gknd 7919 23 Tunisia Tunisia NNP cord-010119-t1x9gknd 7919 24 . . . cord-010119-t1x9gknd 7920 1 The the DT cord-010119-t1x9gknd 7920 2 study study NN cord-010119-t1x9gknd 7920 3 was be VBD cord-010119-t1x9gknd 7920 4 designed design VBN cord-010119-t1x9gknd 7920 5 to to TO cord-010119-t1x9gknd 7920 6 obtain obtain VB cord-010119-t1x9gknd 7920 7 data datum NNS cord-010119-t1x9gknd 7920 8 on on IN cord-010119-t1x9gknd 7920 9 weak weak JJ cord-010119-t1x9gknd 7920 10 D d NN cord-010119-t1x9gknd 7920 11 type type NN cord-010119-t1x9gknd 7920 12 4.0 4.0 CD cord-010119-t1x9gknd 7920 13 in in IN cord-010119-t1x9gknd 7920 14 a a DT cord-010119-t1x9gknd 7920 15 population population NN cord-010119-t1x9gknd 7920 16 known know VBN cord-010119-t1x9gknd 7920 17 to to TO cord-010119-t1x9gknd 7920 18 harbor harbor VB cord-010119-t1x9gknd 7920 19 the the DT cord-010119-t1x9gknd 7920 20 greatest great JJS cord-010119-t1x9gknd 7920 21 prevalence prevalence NN cord-010119-t1x9gknd 7920 22 of of IN cord-010119-t1x9gknd 7920 23 such such JJ cord-010119-t1x9gknd 7920 24 allele allele NN cord-010119-t1x9gknd 7920 25 worldwide worldwide RB cord-010119-t1x9gknd 7920 26 . . . cord-010119-t1x9gknd 7921 1 Study Study NNP cord-010119-t1x9gknd 7921 2 Design Design NNP cord-010119-t1x9gknd 7921 3 / / SYM cord-010119-t1x9gknd 7921 4 Methods method NNS cord-010119-t1x9gknd 7921 5 : : : cord-010119-t1x9gknd 7922 1 A a DT cord-010119-t1x9gknd 7922 2 total total NN cord-010119-t1x9gknd 7922 3 of of IN cord-010119-t1x9gknd 7922 4 13,431 13,431 CD cord-010119-t1x9gknd 7922 5 random random JJ cord-010119-t1x9gknd 7922 6 blood blood NN cord-010119-t1x9gknd 7922 7 donors donor NNS cord-010119-t1x9gknd 7922 8 were be VBD cord-010119-t1x9gknd 7922 9 serologically serologically RB cord-010119-t1x9gknd 7922 10 screened screen VBN cord-010119-t1x9gknd 7922 11 for for IN cord-010119-t1x9gknd 7922 12 the the DT cord-010119-t1x9gknd 7922 13 D D NNP cord-010119-t1x9gknd 7922 14 antigen antigen NN cord-010119-t1x9gknd 7922 15 using use VBG cord-010119-t1x9gknd 7922 16 3 3 CD cord-010119-t1x9gknd 7922 17 routine routine JJ cord-010119-t1x9gknd 7922 18 techniques technique NNS cord-010119-t1x9gknd 7922 19 . . . cord-010119-t1x9gknd 7923 1 Samples sample NNS cord-010119-t1x9gknd 7923 2 with with IN cord-010119-t1x9gknd 7923 3 weak weak JJ cord-010119-t1x9gknd 7923 4 reactivity reactivity NN cord-010119-t1x9gknd 7923 5 were be VBD cord-010119-t1x9gknd 7923 6 tested test VBN cord-010119-t1x9gknd 7923 7 with with IN cord-010119-t1x9gknd 7923 8 a a DT cord-010119-t1x9gknd 7923 9 panel panel NN cord-010119-t1x9gknd 7923 10 of of IN cord-010119-t1x9gknd 7923 11 6 6 CD cord-010119-t1x9gknd 7923 12 monoclonal monoclonal JJ cord-010119-t1x9gknd 7923 13 anti anti JJ cord-010119-t1x9gknd 7923 14 - - JJ cord-010119-t1x9gknd 7923 15 D d JJ cord-010119-t1x9gknd 7923 16 ( ( -LRB- cord-010119-t1x9gknd 7923 17 Partial partial JJ cord-010119-t1x9gknd 7923 18 RhD rhd NN cord-010119-t1x9gknd 7923 19 - - HYPH cord-010119-t1x9gknd 7923 20 Typing typing NN cord-010119-t1x9gknd 7923 21 Set set NN cord-010119-t1x9gknd 7923 22 ) ) -RRB- cord-010119-t1x9gknd 7923 23 to to TO cord-010119-t1x9gknd 7923 24 identify identify VB cord-010119-t1x9gknd 7923 25 partial partial JJ cord-010119-t1x9gknd 7923 26 D d NN cord-010119-t1x9gknd 7923 27 phenotypes phenotype NNS cord-010119-t1x9gknd 7923 28 . . . cord-010119-t1x9gknd 7924 1 The the DT cord-010119-t1x9gknd 7924 2 RHD RHD NNP cord-010119-t1x9gknd 7924 3 gene gene NN cord-010119-t1x9gknd 7924 4 was be VBD cord-010119-t1x9gknd 7924 5 sequenced sequence VBN cord-010119-t1x9gknd 7924 6 in in IN cord-010119-t1x9gknd 7924 7 all all DT cord-010119-t1x9gknd 7924 8 samples sample NNS cord-010119-t1x9gknd 7924 9 with with IN cord-010119-t1x9gknd 7924 10 serologic serologic JJ cord-010119-t1x9gknd 7924 11 weak weak JJ cord-010119-t1x9gknd 7924 12 D d NN cord-010119-t1x9gknd 7924 13 phenotype phenotype NN cord-010119-t1x9gknd 7924 14 . . . cord-010119-t1x9gknd 7925 1 The the DT cord-010119-t1x9gknd 7925 2 RHCE RHCE NNP cord-010119-t1x9gknd 7925 3 gene gene NN cord-010119-t1x9gknd 7925 4 was be VBD cord-010119-t1x9gknd 7925 5 also also RB cord-010119-t1x9gknd 7925 6 tested test VBN cord-010119-t1x9gknd 7925 7 molecularly molecularly RB cord-010119-t1x9gknd 7925 8 by by IN cord-010119-t1x9gknd 7925 9 either either CC cord-010119-t1x9gknd 7925 10 direct direct JJ cord-010119-t1x9gknd 7925 11 sequencing sequencing NN cord-010119-t1x9gknd 7925 12 or or CC cord-010119-t1x9gknd 7925 13 using use VBG cord-010119-t1x9gknd 7925 14 the the DT cord-010119-t1x9gknd 7925 15 RHCE RHCE NNP cord-010119-t1x9gknd 7925 16 BeadChip BeadChip NNP cord-010119-t1x9gknd 7925 17 kit kit NN cord-010119-t1x9gknd 7925 18 to to TO cord-010119-t1x9gknd 7925 19 ascertain ascertain VB cord-010119-t1x9gknd 7925 20 the the DT cord-010119-t1x9gknd 7925 21 RHCE RHCE NNP cord-010119-t1x9gknd 7925 22 allele allele NN cord-010119-t1x9gknd 7925 23 linked link VBN cord-010119-t1x9gknd 7925 24 to to IN cord-010119-t1x9gknd 7925 25 the the DT cord-010119-t1x9gknd 7925 26 RHD RHD NNP cord-010119-t1x9gknd 7925 27 allele allele NN cord-010119-t1x9gknd 7925 28 . . . cord-010119-t1x9gknd 7926 1 Results result NNS cord-010119-t1x9gknd 7926 2 / / SYM cord-010119-t1x9gknd 7926 3 Findings finding NNS cord-010119-t1x9gknd 7926 4 : : : cord-010119-t1x9gknd 7927 1 A a DT cord-010119-t1x9gknd 7927 2 total total NN cord-010119-t1x9gknd 7927 3 of of IN cord-010119-t1x9gknd 7927 4 67 67 CD cord-010119-t1x9gknd 7927 5 discrepant discrepant JJ cord-010119-t1x9gknd 7927 6 samples sample NNS cord-010119-t1x9gknd 7927 7 ( ( -LRB- cord-010119-t1x9gknd 7927 8 0.5 0.5 CD cord-010119-t1x9gknd 7927 9 % % NN cord-010119-t1x9gknd 7927 10 ) ) -RRB- cord-010119-t1x9gknd 7927 11 were be VBD cord-010119-t1x9gknd 7927 12 observed observe VBN cord-010119-t1x9gknd 7927 13 and and CC cord-010119-t1x9gknd 7927 14 expressed express VBD cord-010119-t1x9gknd 7927 15 the the DT cord-010119-t1x9gknd 7927 16 serologic serologic JJ cord-010119-t1x9gknd 7927 17 weak weak JJ cord-010119-t1x9gknd 7927 18 D D NNP cord-010119-t1x9gknd 7927 19 phenotype phenotype NN cord-010119-t1x9gknd 7927 20 . . . cord-010119-t1x9gknd 7928 1 Among among IN cord-010119-t1x9gknd 7928 2 them -PRON- PRP cord-010119-t1x9gknd 7928 3 , , , cord-010119-t1x9gknd 7928 4 60 60 CD cord-010119-t1x9gknd 7928 5 carried carry VBD cord-010119-t1x9gknd 7928 6 an an DT cord-010119-t1x9gknd 7928 7 allele allele NN cord-010119-t1x9gknd 7928 8 of of IN cord-010119-t1x9gknd 7928 9 the the DT cord-010119-t1x9gknd 7928 10 weak weak JJ cord-010119-t1x9gknd 7928 11 D D NNP cord-010119-t1x9gknd 7928 12 type type NN cord-010119-t1x9gknd 7928 13 4 4 CD cord-010119-t1x9gknd 7928 14 cluster cluster NN cord-010119-t1x9gknd 7928 15 ( ( -LRB- cord-010119-t1x9gknd 7928 16 89.6 89.6 CD cord-010119-t1x9gknd 7928 17 % % NN cord-010119-t1x9gknd 7928 18 ) ) -RRB- cord-010119-t1x9gknd 7928 19 , , . cord-010119-t1x9gknd 7929 1 of of IN cord-010119-t1x9gknd 7929 2 which which WDT cord-010119-t1x9gknd 7929 3 53 53 CD cord-010119-t1x9gknd 7929 4 samples sample NNS cord-010119-t1x9gknd 7929 5 ( ( -LRB- cord-010119-t1x9gknd 7929 6 88.3 88.3 CD cord-010119-t1x9gknd 7929 7 % % NN cord-010119-t1x9gknd 7929 8 ) ) -RRB- cord-010119-t1x9gknd 7929 9 showed show VBD cord-010119-t1x9gknd 7929 10 the the DT cord-010119-t1x9gknd 7929 11 weak weak JJ cord-010119-t1x9gknd 7929 12 D D NNP cord-010119-t1x9gknd 7929 13 type type NN cord-010119-t1x9gknd 7929 14 4.0 4.0 CD cord-010119-t1x9gknd 7929 15 allele allele NN cord-010119-t1x9gknd 7929 16 . . . cord-010119-t1x9gknd 7930 1 Only only RB cord-010119-t1x9gknd 7930 2 1 1 CD cord-010119-t1x9gknd 7930 3 sample sample NN cord-010119-t1x9gknd 7930 4 each each DT cord-010119-t1x9gknd 7930 5 was be VBD cord-010119-t1x9gknd 7930 6 found find VBN cord-010119-t1x9gknd 7930 7 for for IN cord-010119-t1x9gknd 7930 8 the the DT cord-010119-t1x9gknd 7930 9 weak weak JJ cord-010119-t1x9gknd 7930 10 D D NNP cord-010119-t1x9gknd 7930 11 types type NNS cord-010119-t1x9gknd 7930 12 1 1 CD cord-010119-t1x9gknd 7930 13 , , , cord-010119-t1x9gknd 7930 14 3 3 CD cord-010119-t1x9gknd 7930 15 and and CC cord-010119-t1x9gknd 7930 16 100 100 CD cord-010119-t1x9gknd 7930 17 and and CC cord-010119-t1x9gknd 7930 18 the the DT cord-010119-t1x9gknd 7930 19 DVII DVII NNP cord-010119-t1x9gknd 7930 20 , , , cord-010119-t1x9gknd 7930 21 while while IN cord-010119-t1x9gknd 7930 22 3 3 CD cord-010119-t1x9gknd 7930 23 samples sample NNS cord-010119-t1x9gknd 7930 24 showed show VBD cord-010119-t1x9gknd 7930 25 the the DT cord-010119-t1x9gknd 7930 26 consensus consensus NN cord-010119-t1x9gknd 7930 27 RHD RHD NNP cord-010119-t1x9gknd 7930 28 sequence sequence NN cord-010119-t1x9gknd 7930 29 . . . cord-010119-t1x9gknd 7931 1 No no DT cord-010119-t1x9gknd 7931 2 mutation mutation NN cord-010119-t1x9gknd 7931 3 in in IN cord-010119-t1x9gknd 7931 4 any any DT cord-010119-t1x9gknd 7931 5 of of IN cord-010119-t1x9gknd 7931 6 the the DT cord-010119-t1x9gknd 7931 7 10 10 CD cord-010119-t1x9gknd 7931 8 RHD RHD NNP cord-010119-t1x9gknd 7931 9 exons exon NNS cord-010119-t1x9gknd 7931 10 was be VBD cord-010119-t1x9gknd 7931 11 detected detect VBN cord-010119-t1x9gknd 7931 12 in in IN cord-010119-t1x9gknd 7931 13 another another DT cord-010119-t1x9gknd 7931 14 3 3 CD cord-010119-t1x9gknd 7931 15 samples sample NNS cord-010119-t1x9gknd 7931 16 . . . cord-010119-t1x9gknd 7932 1 The the DT cord-010119-t1x9gknd 7932 2 molecular molecular JJ cord-010119-t1x9gknd 7932 3 analysis analysis NN cord-010119-t1x9gknd 7932 4 of of IN cord-010119-t1x9gknd 7932 5 the the DT cord-010119-t1x9gknd 7932 6 RHCE RHCE NNP cord-010119-t1x9gknd 7932 7 gene gene NN cord-010119-t1x9gknd 7932 8 showed show VBD cord-010119-t1x9gknd 7932 9 that that IN cord-010119-t1x9gknd 7932 10 59 59 CD cord-010119-t1x9gknd 7932 11 out out IN cord-010119-t1x9gknd 7932 12 of of IN cord-010119-t1x9gknd 7932 13 67 67 CD cord-010119-t1x9gknd 7932 14 samples sample NNS cord-010119-t1x9gknd 7932 15 with with IN cord-010119-t1x9gknd 7932 16 serologic serologic JJ cord-010119-t1x9gknd 7932 17 weak weak JJ cord-010119-t1x9gknd 7932 18 D D NNP cord-010119-t1x9gknd 7932 19 phenotype phenotype NN cord-010119-t1x9gknd 7932 20 ( ( -LRB- cord-010119-t1x9gknd 7932 21 88.06 88.06 CD cord-010119-t1x9gknd 7932 22 % % NN cord-010119-t1x9gknd 7932 23 ) ) -RRB- cord-010119-t1x9gknd 7932 24 had have VBD cord-010119-t1x9gknd 7932 25 a a DT cord-010119-t1x9gknd 7932 26 variant variant JJ cord-010119-t1x9gknd 7932 27 RHCE RHCE NNP cord-010119-t1x9gknd 7932 28 allele allele NN cord-010119-t1x9gknd 7932 29 and and CC cord-010119-t1x9gknd 7932 30 the the DT cord-010119-t1x9gknd 7932 31 most most RBS cord-010119-t1x9gknd 7932 32 common common JJ cord-010119-t1x9gknd 7932 33 associations association NNS cord-010119-t1x9gknd 7932 34 were be VBD cord-010119-t1x9gknd 7932 35 : : : cord-010119-t1x9gknd 7932 36 weak weak JJ cord-010119-t1x9gknd 7932 37 D d NN cord-010119-t1x9gknd 7932 38 type type NN cord-010119-t1x9gknd 7932 39 4.0 4.0 CD cord-010119-t1x9gknd 7932 40 linked link VBN cord-010119-t1x9gknd 7932 41 to to IN cord-010119-t1x9gknd 7932 42 RHCE*ceVS.04.01 rhce*cevs.04.01 JJ cord-010119-t1x9gknd 7932 43 ; ; , cord-010119-t1x9gknd 7932 44 weak weak JJ cord-010119-t1x9gknd 7932 45 D d NN cord-010119-t1x9gknd 7932 46 type type NN cord-010119-t1x9gknd 7932 47 4.2.2 4.2.2 CD cord-010119-t1x9gknd 7932 48 with with IN cord-010119-t1x9gknd 7932 49 ceAR ceAR NNP cord-010119-t1x9gknd 7932 50 ; ; : cord-010119-t1x9gknd 7932 51 and and CC cord-010119-t1x9gknd 7932 52 weak weak JJ cord-010119-t1x9gknd 7932 53 D d NN cord-010119-t1x9gknd 7932 54 type type NN cord-010119-t1x9gknd 7932 55 4.1 4.1 CD cord-010119-t1x9gknd 7932 56 to to IN cord-010119-t1x9gknd 7932 57 RHCE*ceVS.02 RHCE*ceVS.02 NNP cord-010119-t1x9gknd 7932 58 , , , cord-010119-t1x9gknd 7932 59 while while IN cord-010119-t1x9gknd 7932 60 the the DT cord-010119-t1x9gknd 7932 61 other other JJ cord-010119-t1x9gknd 7932 62 RHD RHD NNP cord-010119-t1x9gknd 7932 63 alleles allele NNS cord-010119-t1x9gknd 7932 64 were be VBD cord-010119-t1x9gknd 7932 65 linked link VBN cord-010119-t1x9gknd 7932 66 to to IN cord-010119-t1x9gknd 7932 67 one one CD cord-010119-t1x9gknd 7932 68 of of IN cord-010119-t1x9gknd 7932 69 the the DT cord-010119-t1x9gknd 7932 70 common common JJ cord-010119-t1x9gknd 7932 71 RHCE RHCE NNP cord-010119-t1x9gknd 7932 72 alleles allele NNS cord-010119-t1x9gknd 7932 73 . . . cord-010119-t1x9gknd 7933 1 Conclusion conclusion NN cord-010119-t1x9gknd 7933 2 : : : cord-010119-t1x9gknd 7934 1 Almost almost RB cord-010119-t1x9gknd 7934 2 90 90 CD cord-010119-t1x9gknd 7934 3 % % NN cord-010119-t1x9gknd 7934 4 of of IN cord-010119-t1x9gknd 7934 5 the the DT cord-010119-t1x9gknd 7934 6 weak weak JJ cord-010119-t1x9gknd 7934 7 D d NN cord-010119-t1x9gknd 7934 8 phenotypes phenotype NNS cord-010119-t1x9gknd 7934 9 in in IN cord-010119-t1x9gknd 7934 10 Tunisia Tunisia NNP cord-010119-t1x9gknd 7934 11 were be VBD cord-010119-t1x9gknd 7934 12 caused cause VBN cord-010119-t1x9gknd 7934 13 by by IN cord-010119-t1x9gknd 7934 14 alleles allele NNS cord-010119-t1x9gknd 7934 15 of of IN cord-010119-t1x9gknd 7934 16 the the DT cord-010119-t1x9gknd 7934 17 weak weak JJ cord-010119-t1x9gknd 7934 18 D D NNP cord-010119-t1x9gknd 7934 19 type type NN cord-010119-t1x9gknd 7934 20 4 4 CD cord-010119-t1x9gknd 7934 21 cluster cluster NN cord-010119-t1x9gknd 7934 22 , , , cord-010119-t1x9gknd 7934 23 of of IN cord-010119-t1x9gknd 7934 24 which which WDT cord-010119-t1x9gknd 7934 25 88 88 CD cord-010119-t1x9gknd 7934 26 % % NN cord-010119-t1x9gknd 7934 27 represented represent VBD cord-010119-t1x9gknd 7934 28 the the DT cord-010119-t1x9gknd 7934 29 weak weak JJ cord-010119-t1x9gknd 7934 30 D D NNP cord-010119-t1x9gknd 7934 31 type type NN cord-010119-t1x9gknd 7934 32 4.0 4.0 CD cord-010119-t1x9gknd 7934 33 allele allele NN cord-010119-t1x9gknd 7934 34 . . . cord-010119-t1x9gknd 7935 1 Based base VBN cord-010119-t1x9gknd 7935 2 on on IN cord-010119-t1x9gknd 7935 3 established establish VBN cord-010119-t1x9gknd 7935 4 RH RH NNP cord-010119-t1x9gknd 7935 5 haplotypes haplotype NNS cord-010119-t1x9gknd 7935 6 for for IN cord-010119-t1x9gknd 7935 7 variant variant JJ cord-010119-t1x9gknd 7935 8 RHD RHD NNP cord-010119-t1x9gknd 7935 9 and and CC cord-010119-t1x9gknd 7935 10 RHCE RHCE NNP cord-010119-t1x9gknd 7935 11 alleles allele NNS cord-010119-t1x9gknd 7935 12 and and CC cord-010119-t1x9gknd 7935 13 the the DT cord-010119-t1x9gknd 7935 14 lack lack NN cord-010119-t1x9gknd 7935 15 of of IN cord-010119-t1x9gknd 7935 16 adverse adverse JJ cord-010119-t1x9gknd 7935 17 clinical clinical JJ cord-010119-t1x9gknd 7935 18 reports report NNS cord-010119-t1x9gknd 7935 19 in in IN cord-010119-t1x9gknd 7935 20 Tunisia Tunisia NNP cord-010119-t1x9gknd 7935 21 , , , cord-010119-t1x9gknd 7935 22 we -PRON- PRP cord-010119-t1x9gknd 7935 23 recommend recommend VBP cord-010119-t1x9gknd 7935 24 D D NNP cord-010119-t1x9gknd 7935 25 positive positive JJ cord-010119-t1x9gknd 7935 26 transfusions transfusion NNS cord-010119-t1x9gknd 7935 27 for for IN cord-010119-t1x9gknd 7935 28 patients patient NNS cord-010119-t1x9gknd 7935 29 and and CC cord-010119-t1x9gknd 7935 30 no no DT cord-010119-t1x9gknd 7935 31 RhIG rhig NN cord-010119-t1x9gknd 7935 32 administration administration NN cord-010119-t1x9gknd 7935 33 for for IN cord-010119-t1x9gknd 7935 34 pregnant pregnant JJ cord-010119-t1x9gknd 7935 35 women woman NNS cord-010119-t1x9gknd 7935 36 with with IN cord-010119-t1x9gknd 7935 37 weak weak JJ cord-010119-t1x9gknd 7935 38 D d NN cord-010119-t1x9gknd 7935 39 type type NN cord-010119-t1x9gknd 7935 40 4.0 4.0 CD cord-010119-t1x9gknd 7935 41 in in IN cord-010119-t1x9gknd 7935 42 Tunisia Tunisia NNP cord-010119-t1x9gknd 7935 43 . . . cord-010119-t1x9gknd 7936 1 We -PRON- PRP cord-010119-t1x9gknd 7936 2 propose propose VBP cord-010119-t1x9gknd 7936 3 this this DT cord-010119-t1x9gknd 7936 4 strategy strategy NN cord-010119-t1x9gknd 7936 5 as as IN cord-010119-t1x9gknd 7936 6 a a DT cord-010119-t1x9gknd 7936 7 pragmatic pragmatic JJ cord-010119-t1x9gknd 7936 8 clinical clinical JJ cord-010119-t1x9gknd 7936 9 decision decision NN cord-010119-t1x9gknd 7936 10 , , , cord-010119-t1x9gknd 7936 11 even even RB cord-010119-t1x9gknd 7936 12 if if IN cord-010119-t1x9gknd 7936 13 eventually eventually RB cord-010119-t1x9gknd 7936 14 a a DT cord-010119-t1x9gknd 7936 15 rare rare JJ cord-010119-t1x9gknd 7936 16 allo allo NN cord-010119-t1x9gknd 7936 17 - - HYPH cord-010119-t1x9gknd 7936 18 anti anti JJ cord-010119-t1x9gknd 7936 19 - - JJ cord-010119-t1x9gknd 7936 20 D d JJ cord-010119-t1x9gknd 7936 21 immunization immunization NN cord-010119-t1x9gknd 7936 22 would would MD cord-010119-t1x9gknd 7936 23 occur occur VB cord-010119-t1x9gknd 7936 24 in in IN cord-010119-t1x9gknd 7936 25 Tunisia Tunisia NNP cord-010119-t1x9gknd 7936 26 associated associate VBN cord-010119-t1x9gknd 7936 27 with with IN cord-010119-t1x9gknd 7936 28 weak weak JJ cord-010119-t1x9gknd 7936 29 D d NN cord-010119-t1x9gknd 7936 30 type type NN cord-010119-t1x9gknd 7936 31 4.0 4.0 CD cord-010119-t1x9gknd 7936 32 phenotype phenotype NN cord-010119-t1x9gknd 7936 33 . . . cord-010119-t1x9gknd 7937 1 There there EX cord-010119-t1x9gknd 7937 2 is be VBZ cord-010119-t1x9gknd 7937 3 a a DT cord-010119-t1x9gknd 7937 4 possibility possibility NN cord-010119-t1x9gknd 7937 5 that that IN cord-010119-t1x9gknd 7937 6 the the DT cord-010119-t1x9gknd 7937 7 RHCE*ceVS.04.01 RHCE*ceVS.04.01 NNP cord-010119-t1x9gknd 7937 8 allele allele NN cord-010119-t1x9gknd 7937 9 , , , cord-010119-t1x9gknd 7937 10 typically typically RB cord-010119-t1x9gknd 7937 11 associated associate VBN cord-010119-t1x9gknd 7937 12 in in IN cord-010119-t1x9gknd 7937 13 Tunisian tunisian JJ cord-010119-t1x9gknd 7937 14 individuals individual NNS cord-010119-t1x9gknd 7937 15 , , , cord-010119-t1x9gknd 7937 16 may may MD cord-010119-t1x9gknd 7937 17 protect protect VB cord-010119-t1x9gknd 7937 18 from from IN cord-010119-t1x9gknd 7937 19 allo allo NN cord-010119-t1x9gknd 7937 20 - - HYPH cord-010119-t1x9gknd 7937 21 anti anti JJ cord-010119-t1x9gknd 7937 22 - - JJ cord-010119-t1x9gknd 7937 23 D d JJ cord-010119-t1x9gknd 7937 24 immunizaton immunizaton NN cord-010119-t1x9gknd 7937 25 and and CC cord-010119-t1x9gknd 7937 26 other other JJ cord-010119-t1x9gknd 7937 27 RHCE RHCE NNP cord-010119-t1x9gknd 7937 28 alleles allele NNS cord-010119-t1x9gknd 7937 29 , , , cord-010119-t1x9gknd 7937 30 such such JJ cord-010119-t1x9gknd 7937 31 as as IN cord-010119-t1x9gknd 7937 32 RHCE*ce RHCE*ce NNP cord-010119-t1x9gknd 7937 33 more more RBR cord-010119-t1x9gknd 7937 34 often often RB cord-010119-t1x9gknd 7937 35 associated associate VBN cord-010119-t1x9gknd 7937 36 in in IN cord-010119-t1x9gknd 7937 37 individuals individual NNS cord-010119-t1x9gknd 7937 38 of of IN cord-010119-t1x9gknd 7937 39 other other JJ cord-010119-t1x9gknd 7937 40 ethnic ethnic JJ cord-010119-t1x9gknd 7937 41 groups group NNS cord-010119-t1x9gknd 7937 42 , , , cord-010119-t1x9gknd 7937 43 may may MD cord-010119-t1x9gknd 7937 44 not not RB cord-010119-t1x9gknd 7937 45 . . . cord-010119-t1x9gknd 7938 1 However however RB cord-010119-t1x9gknd 7938 2 , , , cord-010119-t1x9gknd 7938 3 we -PRON- PRP cord-010119-t1x9gknd 7938 4 conclude conclude VBP cord-010119-t1x9gknd 7938 5 that that IN cord-010119-t1x9gknd 7938 6 this this DT cord-010119-t1x9gknd 7938 7 conjecture conjecture NN cord-010119-t1x9gknd 7938 8 has have VBZ cord-010119-t1x9gknd 7938 9 not not RB cord-010119-t1x9gknd 7938 10 much much JJ cord-010119-t1x9gknd 7938 11 evidence evidence NN cord-010119-t1x9gknd 7938 12 in in IN cord-010119-t1x9gknd 7938 13 support support NN cord-010119-t1x9gknd 7938 14 at at IN cord-010119-t1x9gknd 7938 15 this this DT cord-010119-t1x9gknd 7938 16 time time NN cord-010119-t1x9gknd 7938 17 and and CC cord-010119-t1x9gknd 7938 18 would would MD cord-010119-t1x9gknd 7938 19 need need VB cord-010119-t1x9gknd 7938 20 corroboration corroboration NN cord-010119-t1x9gknd 7938 21 by by IN cord-010119-t1x9gknd 7938 22 experimental experimental JJ cord-010119-t1x9gknd 7938 23 and and CC cord-010119-t1x9gknd 7938 24 clinical clinical JJ cord-010119-t1x9gknd 7938 25 data datum NNS cord-010119-t1x9gknd 7938 26 , , , cord-010119-t1x9gknd 7938 27 before before IN cord-010119-t1x9gknd 7938 28 used use VBN cord-010119-t1x9gknd 7938 29 to to TO cord-010119-t1x9gknd 7938 30 guide guide VB cord-010119-t1x9gknd 7938 31 clinical clinical JJ cord-010119-t1x9gknd 7938 32 recommendations recommendation NNS cord-010119-t1x9gknd 7938 33 . . . cord-010119-t1x9gknd 7939 1 Martha Martha NNP cord-010119-t1x9gknd 7939 2 Rae Rae NNP cord-010119-t1x9gknd 7939 3 Combs Combs NNP cord-010119-t1x9gknd 7939 4 * * NFP cord-010119-t1x9gknd 7939 5 1 1 CD cord-010119-t1x9gknd 7939 6 , , , cord-010119-t1x9gknd 7939 7 Heather Heather NNP cord-010119-t1x9gknd 7939 8 Simmons Simmons NNP cord-010119-t1x9gknd 7939 9 1 1 CD cord-010119-t1x9gknd 7939 10 , , , cord-010119-t1x9gknd 7939 11 Christine Christine NNP cord-010119-t1x9gknd 7939 12 Lomas Lomas NNP cord-010119-t1x9gknd 7939 13 - - HYPH cord-010119-t1x9gknd 7939 14 Francis Francis NNP cord-010119-t1x9gknd 7939 15 2 2 CD cord-010119-t1x9gknd 7939 16 , , , cord-010119-t1x9gknd 7939 17 Gayane Gayane NNP cord-010119-t1x9gknd 7939 18 Shakarian shakarian JJ cord-010119-t1x9gknd 7939 19 2 2 CD cord-010119-t1x9gknd 7939 20 , , , cord-010119-t1x9gknd 7939 21 Sunitha Sunitha NNP cord-010119-t1x9gknd 7939 22 Vege Vege NNP cord-010119-t1x9gknd 7939 23 2 2 NNP cord-010119-t1x9gknd 7939 24 , , , cord-010119-t1x9gknd 7939 25 Lauren Lauren NNP cord-010119-t1x9gknd 7939 26 Hutelmyer Hutelmyer NNP cord-010119-t1x9gknd 7939 27 3 3 CD cord-010119-t1x9gknd 7939 28 , , , cord-010119-t1x9gknd 7939 29 Sandra Sandra NNP cord-010119-t1x9gknd 7939 30 Nance Nance NNP cord-010119-t1x9gknd 7939 31 4 4 CD cord-010119-t1x9gknd 7939 32 , , , cord-010119-t1x9gknd 7939 33 Jessica Jessica NNP cord-010119-t1x9gknd 7939 34 Poisson Poisson NNP cord-010119-t1x9gknd 7939 35 1 1 CD cord-010119-t1x9gknd 7939 36 , , , cord-010119-t1x9gknd 7939 37 Nicholas Nicholas NNP cord-010119-t1x9gknd 7939 38 Bandarenko Bandarenko NNP cord-010119-t1x9gknd 7939 39 1 1 CD cord-010119-t1x9gknd 7939 40 and and CC cord-010119-t1x9gknd 7939 41 Connie Connie NNP cord-010119-t1x9gknd 7939 42 M. M. NNP cord-010119-t1x9gknd 7939 43 Westhoff Westhoff NNP cord-010119-t1x9gknd 7939 44 2 2 CD cord-010119-t1x9gknd 7939 45 . . . cord-010119-t1x9gknd 7940 1 1 1 CD cord-010119-t1x9gknd 7940 2 Duke Duke NNP cord-010119-t1x9gknd 7940 3 University University NNP cord-010119-t1x9gknd 7940 4 Hospital Hospital NNP cord-010119-t1x9gknd 7940 5 , , , cord-010119-t1x9gknd 7940 6 2 2 CD cord-010119-t1x9gknd 7940 7 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 7940 8 and and CC cord-010119-t1x9gknd 7940 9 Genomics Genomics NNPS cord-010119-t1x9gknd 7940 10 Laboratory Laboratory NNP cord-010119-t1x9gknd 7940 11 , , , cord-010119-t1x9gknd 7940 12 New New NNP cord-010119-t1x9gknd 7940 13 York York NNP cord-010119-t1x9gknd 7940 14 Blood Blood NNP cord-010119-t1x9gknd 7940 15 Center Center NNP cord-010119-t1x9gknd 7940 16 , , , cord-010119-t1x9gknd 7940 17 3 3 CD cord-010119-t1x9gknd 7940 18 ARC ARC NNP cord-010119-t1x9gknd 7940 19 PennJersey PennJersey NNP cord-010119-t1x9gknd 7940 20 , , , cord-010119-t1x9gknd 7940 21 4 4 CD cord-010119-t1x9gknd 7940 22 American American NNP cord-010119-t1x9gknd 7940 23 Red Red NNP cord-010119-t1x9gknd 7940 24 Cross Cross NNP cord-010119-t1x9gknd 7940 25 , , , cord-010119-t1x9gknd 7940 26 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 7940 27 Reference Reference NNP cord-010119-t1x9gknd 7940 28 Laboratory Laboratory NNP cord-010119-t1x9gknd 7940 29 , , , cord-010119-t1x9gknd 7940 30 Biomedical Biomedical NNP cord-010119-t1x9gknd 7940 31 Services Services NNPS cord-010119-t1x9gknd 7940 32 Background Background NNP cord-010119-t1x9gknd 7940 33 / / SYM cord-010119-t1x9gknd 7940 34 Case Case NNP cord-010119-t1x9gknd 7940 35 Studies Studies NNPS cord-010119-t1x9gknd 7940 36 : : : cord-010119-t1x9gknd 7940 37 Plasma plasma NN cord-010119-t1x9gknd 7940 38 from from IN cord-010119-t1x9gknd 7940 39 a a DT cord-010119-t1x9gknd 7940 40 transfused transfuse VBN cord-010119-t1x9gknd 7940 41 , , , cord-010119-t1x9gknd 7940 42 A1 A1 NNP cord-010119-t1x9gknd 7940 43 , , , cord-010119-t1x9gknd 7940 44 2 2 CD cord-010119-t1x9gknd 7940 45 year year NN cord-010119-t1x9gknd 7940 46 old old JJ cord-010119-t1x9gknd 7940 47 white white JJ cord-010119-t1x9gknd 7940 48 female female NN cord-010119-t1x9gknd 7940 49 , , , cord-010119-t1x9gknd 7940 50 post post NN cord-010119-t1x9gknd 7940 51 liver liver NN cord-010119-t1x9gknd 7940 52 transplant transplant NN cord-010119-t1x9gknd 7940 53 with with IN cord-010119-t1x9gknd 7940 54 RBC RBC NNP cord-010119-t1x9gknd 7940 55 aplasia aplasia NNP cord-010119-t1x9gknd 7940 56 , , , cord-010119-t1x9gknd 7940 57 reacted react VBD cord-010119-t1x9gknd 7940 58 at at IN cord-010119-t1x9gknd 7940 59 RT RT NNP cord-010119-t1x9gknd 7940 60 and and CC cord-010119-t1x9gknd 7940 61 in in IN cord-010119-t1x9gknd 7940 62 PEG PEG NNP cord-010119-t1x9gknd 7940 63 IAT IAT NNP cord-010119-t1x9gknd 7940 64 with with IN cord-010119-t1x9gknd 7940 65 all all DT cord-010119-t1x9gknd 7940 66 RBC RBC NNP cord-010119-t1x9gknd 7940 67 samples sample NNS cord-010119-t1x9gknd 7940 68 tested test VBN cord-010119-t1x9gknd 7940 69 except except IN cord-010119-t1x9gknd 7940 70 her -PRON- PRP$ cord-010119-t1x9gknd 7940 71 own own JJ cord-010119-t1x9gknd 7940 72 . . . cord-010119-t1x9gknd 7941 1 Study Study NNP cord-010119-t1x9gknd 7941 2 Design Design NNP cord-010119-t1x9gknd 7941 3 / / SYM cord-010119-t1x9gknd 7941 4 Method method NN cord-010119-t1x9gknd 7941 5 : : : cord-010119-t1x9gknd 7942 1 Standard standard JJ cord-010119-t1x9gknd 7942 2 hemagglutination hemagglutination NN cord-010119-t1x9gknd 7942 3 methods method NNS cord-010119-t1x9gknd 7942 4 were be VBD cord-010119-t1x9gknd 7942 5 used use VBN cord-010119-t1x9gknd 7942 6 for for IN cord-010119-t1x9gknd 7942 7 antibody antibody NN cord-010119-t1x9gknd 7942 8 ID ID NNP cord-010119-t1x9gknd 7942 9 and and CC cord-010119-t1x9gknd 7942 10 antigen antigen NN cord-010119-t1x9gknd 7942 11 typing typing NN cord-010119-t1x9gknd 7942 12 . . . cord-010119-t1x9gknd 7943 1 Acid acid NN cord-010119-t1x9gknd 7943 2 eluates eluate NNS cord-010119-t1x9gknd 7943 3 were be VBD cord-010119-t1x9gknd 7943 4 prepared prepare VBN cord-010119-t1x9gknd 7943 5 using use VBG cord-010119-t1x9gknd 7943 6 Gamma Gamma NNP cord-010119-t1x9gknd 7943 7 ELU ELU NNP cord-010119-t1x9gknd 7943 8 - - HYPH cord-010119-t1x9gknd 7943 9 KIT KIT NNP cord-010119-t1x9gknd 7943 10 II II NNP cord-010119-t1x9gknd 7943 11 ( ( -LRB- cord-010119-t1x9gknd 7943 12 Immucor Immucor NNP cord-010119-t1x9gknd 7943 13 ) ) -RRB- cord-010119-t1x9gknd 7943 14 . . . cord-010119-t1x9gknd 7944 1 Genomic genomic JJ cord-010119-t1x9gknd 7944 2 DNA dna NN cord-010119-t1x9gknd 7944 3 was be VBD cord-010119-t1x9gknd 7944 4 isolated isolate VBN cord-010119-t1x9gknd 7944 5 from from IN cord-010119-t1x9gknd 7944 6 WBCs wbc NNS cord-010119-t1x9gknd 7944 7 and and CC cord-010119-t1x9gknd 7944 8 used use VBN cord-010119-t1x9gknd 7944 9 for for IN cord-010119-t1x9gknd 7944 10 HEA HEA NNP cord-010119-t1x9gknd 7944 11 PreciseType PreciseType NNP cord-010119-t1x9gknd 7944 12 array array NN cord-010119-t1x9gknd 7944 13 and and CC cord-010119-t1x9gknd 7944 14 KEL KEL NNP cord-010119-t1x9gknd 7944 15 and and CC cord-010119-t1x9gknd 7944 16 SC SC NNP cord-010119-t1x9gknd 7944 17 gene gene NN cord-010119-t1x9gknd 7944 18 sequencing sequencing NN cord-010119-t1x9gknd 7944 19 . . . cord-010119-t1x9gknd 7945 1 Samples sample NNS cord-010119-t1x9gknd 7945 2 from from IN cord-010119-t1x9gknd 7945 3 the the DT cord-010119-t1x9gknd 7945 4 proband proband NN cord-010119-t1x9gknd 7945 5 and and CC cord-010119-t1x9gknd 7945 6 her -PRON- PRP$ cord-010119-t1x9gknd 7945 7 mother mother NN cord-010119-t1x9gknd 7945 8 were be VBD cord-010119-t1x9gknd 7945 9 tested test VBN cord-010119-t1x9gknd 7945 10 , , , cord-010119-t1x9gknd 7945 11 as as IN cord-010119-t1x9gknd 7945 12 applicable applicable JJ cord-010119-t1x9gknd 7945 13 . . . cord-010119-t1x9gknd 7946 1 Results result NNS cord-010119-t1x9gknd 7946 2 / / SYM cord-010119-t1x9gknd 7946 3 Finding finding NN cord-010119-t1x9gknd 7946 4 : : : cord-010119-t1x9gknd 7946 5 The the DT cord-010119-t1x9gknd 7946 6 patient patient NN cord-010119-t1x9gknd 7946 7 's 's POS cord-010119-t1x9gknd 7946 8 DAT DAT NNP cord-010119-t1x9gknd 7946 9 was be VBD cord-010119-t1x9gknd 7946 10 negative negative JJ cord-010119-t1x9gknd 7946 11 . . . cord-010119-t1x9gknd 7947 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7947 2 plasma plasma NN cord-010119-t1x9gknd 7947 3 reacted react VBD cord-010119-t1x9gknd 7947 4 with with IN cord-010119-t1x9gknd 7947 5 0.2 0.2 CD cord-010119-t1x9gknd 7947 6 M M NNP cord-010119-t1x9gknd 7947 7 DTT DTT NNP cord-010119-t1x9gknd 7947 8 - - HYPH cord-010119-t1x9gknd 7947 9 treated treat VBN cord-010119-t1x9gknd 7947 10 and and CC cord-010119-t1x9gknd 7947 11 papain papain NN cord-010119-t1x9gknd 7947 12 - - HYPH cord-010119-t1x9gknd 7947 13 treated treat VBN cord-010119-t1x9gknd 7947 14 RBCs rbc NNS cord-010119-t1x9gknd 7947 15 , , , cord-010119-t1x9gknd 7947 16 all all DT cord-010119-t1x9gknd 7947 17 available available JJ cord-010119-t1x9gknd 7947 18 RBC RBC NNP cord-010119-t1x9gknd 7947 19 samples sample NNS cord-010119-t1x9gknd 7947 20 lacking lack VBG cord-010119-t1x9gknd 7947 21 high high JJ cord-010119-t1x9gknd 7947 22 - - HYPH cord-010119-t1x9gknd 7947 23 prevalence prevalence NN cord-010119-t1x9gknd 7947 24 antigens antigen NNS cord-010119-t1x9gknd 7947 25 , , , cord-010119-t1x9gknd 7947 26 and and CC cord-010119-t1x9gknd 7947 27 with with IN cord-010119-t1x9gknd 7947 28 phenotypically phenotypically RB cord-010119-t1x9gknd 7947 29 similar similar JJ cord-010119-t1x9gknd 7947 30 RBC RBC NNP cord-010119-t1x9gknd 7947 31 samples sample NNS cord-010119-t1x9gknd 7947 32 [ [ -LRB- cord-010119-t1x9gknd 7947 33 C2 C2 NNP cord-010119-t1x9gknd 7947 34 , , , cord-010119-t1x9gknd 7947 35 K2 K2 NNP cord-010119-t1x9gknd 7947 36 , , , cord-010119-t1x9gknd 7947 37 Fy(a2),S2 Fy(a2),S2 NNP cord-010119-t1x9gknd 7947 38 ] ] -RRB- cord-010119-t1x9gknd 7947 39 . . . cord-010119-t1x9gknd 7948 1 Reactivity reactivity NN cord-010119-t1x9gknd 7948 2 was be VBD cord-010119-t1x9gknd 7948 3 detected detect VBN cord-010119-t1x9gknd 7948 4 to to IN cord-010119-t1x9gknd 7948 5 a a DT cord-010119-t1x9gknd 7948 6 titer titer NN cord-010119-t1x9gknd 7948 7 of of IN cord-010119-t1x9gknd 7948 8 64 64 CD cord-010119-t1x9gknd 7948 9 ; ; : cord-010119-t1x9gknd 7948 10 it -PRON- PRP cord-010119-t1x9gknd 7948 11 was be VBD cord-010119-t1x9gknd 7948 12 not not RB cord-010119-t1x9gknd 7948 13 removed remove VBN cord-010119-t1x9gknd 7948 14 by by IN cord-010119-t1x9gknd 7948 15 prewarm prewarm NNS cord-010119-t1x9gknd 7948 16 technique technique NN cord-010119-t1x9gknd 7948 17 or or CC cord-010119-t1x9gknd 7948 18 by by IN cord-010119-t1x9gknd 7948 19 4x 4x CD cord-010119-t1x9gknd 7948 20 PEG PEG NNP cord-010119-t1x9gknd 7948 21 alloadsorption alloadsorption NN cord-010119-t1x9gknd 7948 22 . . . cord-010119-t1x9gknd 7949 1 The the DT cord-010119-t1x9gknd 7949 2 adsorbed adsorb VBN cord-010119-t1x9gknd 7949 3 plasma plasma NN cord-010119-t1x9gknd 7949 4 reacted react VBD cord-010119-t1x9gknd 7949 5 with with IN cord-010119-t1x9gknd 7949 6 0.2 0.2 CD cord-010119-t1x9gknd 7949 7 M M NNP cord-010119-t1x9gknd 7949 8 DTT DTT NNP cord-010119-t1x9gknd 7949 9 - - HYPH cord-010119-t1x9gknd 7949 10 treated treat VBN cord-010119-t1x9gknd 7949 11 RBCs rbc NNS cord-010119-t1x9gknd 7949 12 . . . cord-010119-t1x9gknd 7950 1 Extensive extensive JJ cord-010119-t1x9gknd 7950 2 RBC RBC NNP cord-010119-t1x9gknd 7950 3 phenotype phenotype NN cord-010119-t1x9gknd 7950 4 results result NNS cord-010119-t1x9gknd 7950 5 were be VBD cord-010119-t1x9gknd 7950 6 unremarkable unremarkable JJ cord-010119-t1x9gknd 7950 7 except except IN cord-010119-t1x9gknd 7950 8 for for IN cord-010119-t1x9gknd 7950 9 the the DT cord-010119-t1x9gknd 7950 10 following follow VBG cord-010119-t1x9gknd 7950 11 : : : cord-010119-t1x9gknd 7950 12 K2 K2 NNP cord-010119-t1x9gknd 7950 13 , , , cord-010119-t1x9gknd 7950 14 k2 k2 NNP cord-010119-t1x9gknd 7950 15 , , , cord-010119-t1x9gknd 7950 16 Js(b2 Js(b2 NNP cord-010119-t1x9gknd 7950 17 ) ) -RRB- cord-010119-t1x9gknd 7950 18 , , , cord-010119-t1x9gknd 7950 19 Kp(a2b2 Kp(a2b2 NNP cord-010119-t1x9gknd 7950 20 ) ) -RRB- cord-010119-t1x9gknd 7950 21 and and CC cord-010119-t1x9gknd 7950 22 Sc:21,23 Sc:21,23 VBD cord-010119-t1x9gknd 7950 23 . . . cord-010119-t1x9gknd 7951 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7951 2 plasma plasma NN cord-010119-t1x9gknd 7951 3 reacted react VBD cord-010119-t1x9gknd 7951 4 with with IN cord-010119-t1x9gknd 7951 5 K K NNP cord-010119-t1x9gknd 7951 6 o o NNP cord-010119-t1x9gknd 7951 7 , , , cord-010119-t1x9gknd 7951 8 McLeod McLeod NNP cord-010119-t1x9gknd 7951 9 , , , cord-010119-t1x9gknd 7951 10 Sc:21,22 Sc:21,22 NNP cord-010119-t1x9gknd 7951 11 RBC RBC NNP cord-010119-t1x9gknd 7951 12 samples sample NNS cord-010119-t1x9gknd 7951 13 and and CC cord-010119-t1x9gknd 7951 14 DTT DTT NNP cord-010119-t1x9gknd 7951 15 - - HYPH cord-010119-t1x9gknd 7951 16 treated treat VBN cord-010119-t1x9gknd 7951 17 Sc:21 Sc:21 NNP cord-010119-t1x9gknd 7951 18 RBCs rbc NNS cord-010119-t1x9gknd 7951 19 at at IN cord-010119-t1x9gknd 7951 20 RT RT NNP cord-010119-t1x9gknd 7951 21 and and CC cord-010119-t1x9gknd 7951 22 PEG PEG NNP cord-010119-t1x9gknd 7951 23 IAT IAT NNP cord-010119-t1x9gknd 7952 1 but but CC cord-010119-t1x9gknd 7952 2 her -PRON- PRP$ cord-010119-t1x9gknd 7952 3 diluted diluted JJ cord-010119-t1x9gknd 7952 4 plasma plasma NN cord-010119-t1x9gknd 7952 5 and and CC cord-010119-t1x9gknd 7952 6 pretransfusion pretransfusion NN cord-010119-t1x9gknd 7952 7 eluate eluate NNP cord-010119-t1x9gknd 7952 8 showed show VBD cord-010119-t1x9gknd 7952 9 relative relative JJ cord-010119-t1x9gknd 7952 10 Kp Kp NNP cord-010119-t1x9gknd 7952 11 b b NN cord-010119-t1x9gknd 7952 12 specificity specificity NN cord-010119-t1x9gknd 7952 13 . . . cord-010119-t1x9gknd 7953 1 The the DT cord-010119-t1x9gknd 7953 2 patient patient NN cord-010119-t1x9gknd 7953 3 was be VBD cord-010119-t1x9gknd 7953 4 transfused transfuse VBN cord-010119-t1x9gknd 7953 5 4 4 CD cord-010119-t1x9gknd 7953 6 aliquots aliquot NNS cord-010119-t1x9gknd 7953 7 of of IN cord-010119-t1x9gknd 7953 8 crossmatch crossmatch NN cord-010119-t1x9gknd 7953 9 incompatible incompatible JJ cord-010119-t1x9gknd 7953 10 Kp(b2 Kp(b2 NNP cord-010119-t1x9gknd 7953 11 ) ) -RRB- cord-010119-t1x9gknd 7953 12 , , , cord-010119-t1x9gknd 7953 13 S2 S2 NNP cord-010119-t1x9gknd 7953 14 RBCs rbc NNS cord-010119-t1x9gknd 7953 15 . . . cord-010119-t1x9gknd 7954 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7954 2 post post JJ cord-010119-t1x9gknd 7954 3 - - JJ cord-010119-t1x9gknd 7954 4 transfusion transfusion NN cord-010119-t1x9gknd 7954 5 DAT DAT NNP cord-010119-t1x9gknd 7954 6 was be VBD cord-010119-t1x9gknd 7954 7 21 21 CD cord-010119-t1x9gknd 7954 8 with with IN cord-010119-t1x9gknd 7954 9 anti anti JJ cord-010119-t1x9gknd 7954 10 - - JJ cord-010119-t1x9gknd 7954 11 IgG igg JJ cord-010119-t1x9gknd 7954 12 , , , cord-010119-t1x9gknd 7954 13 11 11 CD cord-010119-t1x9gknd 7954 14 with with IN cord-010119-t1x9gknd 7954 15 anti anti JJ cord-010119-t1x9gknd 7954 16 - - JJ cord-010119-t1x9gknd 7954 17 C3d c3d JJ cord-010119-t1x9gknd 7954 18 . . . cord-010119-t1x9gknd 7955 1 The the DT cord-010119-t1x9gknd 7955 2 eluate eluate NN cord-010119-t1x9gknd 7955 3 reacted react VBD cord-010119-t1x9gknd 7955 4 with with IN cord-010119-t1x9gknd 7955 5 all all DT cord-010119-t1x9gknd 7955 6 RBC RBC NNP cord-010119-t1x9gknd 7955 7 samples sample NNS cord-010119-t1x9gknd 7955 8 except except IN cord-010119-t1x9gknd 7955 9 1 1 CD cord-010119-t1x9gknd 7955 10 Kp(b2 kp(b2 CD cord-010119-t1x9gknd 7955 11 ) ) -RRB- cord-010119-t1x9gknd 7955 12 sample sample NN cord-010119-t1x9gknd 7955 13 . . . cord-010119-t1x9gknd 7956 1 She -PRON- PRP cord-010119-t1x9gknd 7956 2 tolerated tolerate VBD cord-010119-t1x9gknd 7956 3 additional additional JJ cord-010119-t1x9gknd 7956 4 aliquots aliquot NNS cord-010119-t1x9gknd 7956 5 from from IN cord-010119-t1x9gknd 7956 6 4 4 CD cord-010119-t1x9gknd 7956 7 phenotypically phenotypically RB cord-010119-t1x9gknd 7956 8 similar similar JJ cord-010119-t1x9gknd 7956 9 RBCs rbc NNS cord-010119-t1x9gknd 7956 10 untested untested JJ cord-010119-t1x9gknd 7956 11 for for IN cord-010119-t1x9gknd 7956 12 high high JJ cord-010119-t1x9gknd 7956 13 - - HYPH cord-010119-t1x9gknd 7956 14 prevalence prevalence NN cord-010119-t1x9gknd 7956 15 Kell Kell NNP cord-010119-t1x9gknd 7956 16 or or CC cord-010119-t1x9gknd 7956 17 Scianna Scianna NNP cord-010119-t1x9gknd 7956 18 antigens antigen NNS cord-010119-t1x9gknd 7956 19 . . . cord-010119-t1x9gknd 7957 1 The the DT cord-010119-t1x9gknd 7957 2 HEA HEA NNP cord-010119-t1x9gknd 7957 3 Precise Precise NNP cord-010119-t1x9gknd 7957 4 - - HYPH cord-010119-t1x9gknd 7957 5 Type Type NNP cord-010119-t1x9gknd 7957 6 predicted predict VBD cord-010119-t1x9gknd 7957 7 K2 K2 NNP cord-010119-t1x9gknd 7957 8 , , , cord-010119-t1x9gknd 7957 9 k1 k1 NNP cord-010119-t1x9gknd 7957 10 , , , cord-010119-t1x9gknd 7957 11 Kp(a2b1 Kp(a2b1 NNP cord-010119-t1x9gknd 7957 12 ) ) -RRB- cord-010119-t1x9gknd 7957 13 , , , cord-010119-t1x9gknd 7957 14 Js(a2b1 Js(a2b1 NNP cord-010119-t1x9gknd 7957 15 ) ) -RRB- cord-010119-t1x9gknd 7957 16 and and CC cord-010119-t1x9gknd 7957 17 Sc:1,22 Sc:1,22 NNP cord-010119-t1x9gknd 7957 18 , , , cord-010119-t1x9gknd 7957 19 discordant discordant JJ cord-010119-t1x9gknd 7957 20 with with IN cord-010119-t1x9gknd 7957 21 her -PRON- PRP$ cord-010119-t1x9gknd 7957 22 RBC RBC NNP cord-010119-t1x9gknd 7957 23 phenotype phenotype NN cord-010119-t1x9gknd 7957 24 . . . cord-010119-t1x9gknd 7958 1 KEL KEL NNP cord-010119-t1x9gknd 7958 2 gene gene NN cord-010119-t1x9gknd 7958 3 sequencing sequencing NN cord-010119-t1x9gknd 7958 4 identified identify VBD cord-010119-t1x9gknd 7958 5 a a DT cord-010119-t1x9gknd 7958 6 homozygous homozygous JJ cord-010119-t1x9gknd 7958 7 change change NN cord-010119-t1x9gknd 7958 8 , , , cord-010119-t1x9gknd 7958 9 c.1481A c.1481A NNP cord-010119-t1x9gknd 7959 1 > > XX cord-010119-t1x9gknd 7960 1 T T NNP cord-010119-t1x9gknd 7960 2 ( ( -LRB- cord-010119-t1x9gknd 7960 3 p. p. NN cord-010119-t1x9gknd 7961 1 Glu494Val glu494val LS cord-010119-t1x9gknd 7961 2 ) ) -RRB- cord-010119-t1x9gknd 7962 1 ( ( -LRB- cord-010119-t1x9gknd 7962 2 KEL*02.10 KEL*02.10 NNP cord-010119-t1x9gknd 7962 3 ) ) -RRB- cord-010119-t1x9gknd 7962 4 encoding encode VBG cord-010119-t1x9gknd 7962 5 the the DT cord-010119-t1x9gknd 7962 6 low low JJ cord-010119-t1x9gknd 7962 7 prevalence prevalence NN cord-010119-t1x9gknd 7962 8 antigen antigen NN cord-010119-t1x9gknd 7962 9 , , , cord-010119-t1x9gknd 7962 10 Ul Ul NNP cord-010119-t1x9gknd 7962 11 a a DT cord-010119-t1x9gknd 7962 12 , , , cord-010119-t1x9gknd 7962 13 but but CC cord-010119-t1x9gknd 7962 14 no no DT cord-010119-t1x9gknd 7962 15 changes change NNS cord-010119-t1x9gknd 7962 16 associated associate VBN cord-010119-t1x9gknd 7962 17 with with IN cord-010119-t1x9gknd 7962 18 lack lack NN cord-010119-t1x9gknd 7962 19 of of IN cord-010119-t1x9gknd 7962 20 Kell Kell NNP cord-010119-t1x9gknd 7962 21 system system NN cord-010119-t1x9gknd 7962 22 antigens antigen NNS cord-010119-t1x9gknd 7962 23 ; ; : cord-010119-t1x9gknd 7962 24 however however RB cord-010119-t1x9gknd 7962 25 , , , cord-010119-t1x9gknd 7962 26 her -PRON- PRP$ cord-010119-t1x9gknd 7962 27 RBCs rbc NNS cord-010119-t1x9gknd 7962 28 typed type VBD cord-010119-t1x9gknd 7962 29 Ul(a2 ul(a2 CD cord-010119-t1x9gknd 7962 30 ) ) -RRB- cord-010119-t1x9gknd 7962 31 . . . cord-010119-t1x9gknd 7963 1 SC SC NNP cord-010119-t1x9gknd 7963 2 sequencing sequencing NN cord-010119-t1x9gknd 7963 3 found find VBD cord-010119-t1x9gknd 7963 4 heterozygosity heterozygosity NN cord-010119-t1x9gknd 7963 5 for for IN cord-010119-t1x9gknd 7963 6 a a DT cord-010119-t1x9gknd 7963 7 5'-2g 5'-2g CD cord-010119-t1x9gknd 7963 8 > > XX cord-010119-t1x9gknd 7963 9 a a DT cord-010119-t1x9gknd 7963 10 change change NN cord-010119-t1x9gknd 7963 11 ( ( -LRB- cord-010119-t1x9gknd 7963 12 rs12124733 rs12124733 NNP cord-010119-t1x9gknd 7963 13 , , , cord-010119-t1x9gknd 7963 14 24 24 CD cord-010119-t1x9gknd 7963 15 to to TO cord-010119-t1x9gknd 7963 16 30 30 CD cord-010119-t1x9gknd 7963 17 % % NN cord-010119-t1x9gknd 7963 18 prevalence prevalence NN cord-010119-t1x9gknd 7963 19 ) ) -RRB- cord-010119-t1x9gknd 7963 20 and and CC cord-010119-t1x9gknd 7963 21 conventional conventional JJ cord-010119-t1x9gknd 7963 22 SC*01 SC*01 NNS cord-010119-t1x9gknd 7963 23 , , , cord-010119-t1x9gknd 7963 24 predicting predict VBG cord-010119-t1x9gknd 7963 25 Sc:1,22,3 Sc:1,22,3 NNP cord-010119-t1x9gknd 7963 26 . . . cord-010119-t1x9gknd 7964 1 KEL KEL NNP cord-010119-t1x9gknd 7964 2 and and CC cord-010119-t1x9gknd 7964 3 SC SC NNP cord-010119-t1x9gknd 7964 4 results result NNS cord-010119-t1x9gknd 7964 5 on on IN cord-010119-t1x9gknd 7964 6 the the DT cord-010119-t1x9gknd 7964 7 mother mother NN cord-010119-t1x9gknd 7964 8 were be VBD cord-010119-t1x9gknd 7964 9 KEL*02 KEL*02 NNP cord-010119-t1x9gknd 7964 10 / / SYM cord-010119-t1x9gknd 7964 11 KEL*02.10 KEL*02.10 NNS cord-010119-t1x9gknd 7964 12 , , , cord-010119-t1x9gknd 7964 13 heterozygous heterozygous JJ cord-010119-t1x9gknd 7964 14 for for IN cord-010119-t1x9gknd 7964 15 the the DT cord-010119-t1x9gknd 7964 16 SC SC NNP cord-010119-t1x9gknd 7964 17 change change NN cord-010119-t1x9gknd 7965 1 5'-2 5'-2 CD cord-010119-t1x9gknd 7965 2 g g NN cord-010119-t1x9gknd 7965 3 > > XX cord-010119-t1x9gknd 7966 1 a a LS cord-010119-t1x9gknd 7966 2 , , , cord-010119-t1x9gknd 7966 3 and and CC cord-010119-t1x9gknd 7966 4 her -PRON- PRP$ cord-010119-t1x9gknd 7966 5 RBCs rbc NNS cord-010119-t1x9gknd 7966 6 typed type VBD cord-010119-t1x9gknd 7966 7 K2k1 K2k1 NNP cord-010119-t1x9gknd 7966 8 Kp(a2b1 Kp(a2b1 NNP cord-010119-t1x9gknd 7966 9 ) ) -RRB- cord-010119-t1x9gknd 7966 10 , , , cord-010119-t1x9gknd 7966 11 Sc31 Sc31 NNP cord-010119-t1x9gknd 7966 12 , , , cord-010119-t1x9gknd 7966 13 Ula1 Ula1 NNP cord-010119-t1x9gknd 7966 14 , , , cord-010119-t1x9gknd 7966 15 consistent consistent JJ cord-010119-t1x9gknd 7966 16 with with IN cord-010119-t1x9gknd 7966 17 DNA dna NN cord-010119-t1x9gknd 7966 18 predictions prediction NNS cord-010119-t1x9gknd 7966 19 . . . cord-010119-t1x9gknd 7967 1 Plasma plasma NN cord-010119-t1x9gknd 7967 2 collected collect VBD cord-010119-t1x9gknd 7967 3 7 7 CD cord-010119-t1x9gknd 7967 4 months month NNS cord-010119-t1x9gknd 7967 5 later later RB cord-010119-t1x9gknd 7967 6 was be VBD cord-010119-t1x9gknd 7967 7 nonreactive nonreactive JJ cord-010119-t1x9gknd 7967 8 at at IN cord-010119-t1x9gknd 7967 9 RT RT NNP cord-010119-t1x9gknd 7967 10 and and CC cord-010119-t1x9gknd 7967 11 in in IN cord-010119-t1x9gknd 7967 12 PEG PEG NNP cord-010119-t1x9gknd 7967 13 IAT IAT NNP cord-010119-t1x9gknd 7967 14 . . . cord-010119-t1x9gknd 7968 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7968 2 RBCs rbc NNS cord-010119-t1x9gknd 7968 3 were be VBD cord-010119-t1x9gknd 7968 4 DAT2 DAT2 NNS cord-010119-t1x9gknd 7968 5 and and CC cord-010119-t1x9gknd 7968 6 now now RB cord-010119-t1x9gknd 7968 7 typed type VBN cord-010119-t1x9gknd 7968 8 k1 k1 NNP cord-010119-t1x9gknd 7968 9 , , , cord-010119-t1x9gknd 7968 10 Kp(a2b1 Kp(a2b1 NNP cord-010119-t1x9gknd 7968 11 ) ) -RRB- cord-010119-t1x9gknd 7968 12 , , , cord-010119-t1x9gknd 7968 13 Ul(a1 Ul(a1 NNP cord-010119-t1x9gknd 7968 14 ) ) -RRB- cord-010119-t1x9gknd 7969 1 Sc11 Sc11 NNP cord-010119-t1x9gknd 7969 2 and and CC cord-010119-t1x9gknd 7969 3 Sc31,concordant Sc31,concordant NNP cord-010119-t1x9gknd 7969 4 with with IN cord-010119-t1x9gknd 7969 5 predicted predict VBN cord-010119-t1x9gknd 7969 6 Kell Kell NNP cord-010119-t1x9gknd 7969 7 and and CC cord-010119-t1x9gknd 7969 8 Sc Sc NNP cord-010119-t1x9gknd 7969 9 phenotypes phenotype NNS cord-010119-t1x9gknd 7969 10 . . . cord-010119-t1x9gknd 7970 1 Conclusion conclusion NN cord-010119-t1x9gknd 7970 2 : : : cord-010119-t1x9gknd 7970 3 We -PRON- PRP cord-010119-t1x9gknd 7970 4 report report VBP cord-010119-t1x9gknd 7970 5 an an DT cord-010119-t1x9gknd 7970 6 example example NN cord-010119-t1x9gknd 7970 7 of of IN cord-010119-t1x9gknd 7970 8 Kell Kell NNP cord-010119-t1x9gknd 7970 9 and and CC cord-010119-t1x9gknd 7970 10 Scianna Scianna NNP cord-010119-t1x9gknd 7970 11 antigen antigen NN cord-010119-t1x9gknd 7970 12 suppression suppression NN cord-010119-t1x9gknd 7970 13 or or CC cord-010119-t1x9gknd 7970 14 blocking block VBG cord-010119-t1x9gknd 7970 15 in in IN cord-010119-t1x9gknd 7970 16 the the DT cord-010119-t1x9gknd 7970 17 presence presence NN cord-010119-t1x9gknd 7970 18 of of IN cord-010119-t1x9gknd 7970 19 autoantibody autoantibody NNP cord-010119-t1x9gknd 7970 20 or or CC cord-010119-t1x9gknd 7970 21 an an DT cord-010119-t1x9gknd 7970 22 alloantibody alloantibody NN cord-010119-t1x9gknd 7970 23 in in IN cord-010119-t1x9gknd 7970 24 the the DT cord-010119-t1x9gknd 7970 25 KEL KEL NNP cord-010119-t1x9gknd 7970 26 system system NN cord-010119-t1x9gknd 7970 27 . . . cord-010119-t1x9gknd 7971 1 To to IN cord-010119-t1x9gknd 7971 2 our -PRON- PRP$ cord-010119-t1x9gknd 7971 3 knowledge knowledge NN cord-010119-t1x9gknd 7971 4 , , , cord-010119-t1x9gknd 7971 5 this this DT cord-010119-t1x9gknd 7971 6 is be VBZ cord-010119-t1x9gknd 7971 7 the the DT cord-010119-t1x9gknd 7971 8 first first JJ cord-010119-t1x9gknd 7971 9 report report NN cord-010119-t1x9gknd 7971 10 of of IN cord-010119-t1x9gknd 7971 11 a a DT cord-010119-t1x9gknd 7971 12 Ul Ul NNP cord-010119-t1x9gknd 7971 13 a a DT cord-010119-t1x9gknd 7971 14 KEL*02.10 kel*02.10 JJ cord-010119-t1x9gknd 7971 15 homozygote homozygote NN cord-010119-t1x9gknd 7971 16 . . . cord-010119-t1x9gknd 7972 1 The the DT cord-010119-t1x9gknd 7972 2 RBCs rbc NNS cord-010119-t1x9gknd 7972 3 may may MD cord-010119-t1x9gknd 7972 4 lack lack VB cord-010119-t1x9gknd 7972 5 a a DT cord-010119-t1x9gknd 7972 6 high high JJ cord-010119-t1x9gknd 7972 7 - - HYPH cord-010119-t1x9gknd 7972 8 prevalence prevalence NN cord-010119-t1x9gknd 7972 9 antigen antigen NN cord-010119-t1x9gknd 7972 10 antithetical antithetical JJ cord-010119-t1x9gknd 7972 11 to to IN cord-010119-t1x9gknd 7972 12 Ul Ul NNP cord-010119-t1x9gknd 7972 13 a a DT cord-010119-t1x9gknd 7972 14 . . . cord-010119-t1x9gknd 7973 1 Without without IN cord-010119-t1x9gknd 7973 2 DNA dna NN cord-010119-t1x9gknd 7973 3 testing testing NN cord-010119-t1x9gknd 7973 4 and and CC cord-010119-t1x9gknd 7973 5 gene gene NN cord-010119-t1x9gknd 7973 6 sequencing sequencing NN cord-010119-t1x9gknd 7973 7 , , , cord-010119-t1x9gknd 7973 8 the the DT cord-010119-t1x9gknd 7973 9 patient patient NN cord-010119-t1x9gknd 7973 10 would would MD cord-010119-t1x9gknd 7973 11 be be VB cord-010119-t1x9gknd 7973 12 presumed presume VBN cord-010119-t1x9gknd 7973 13 to to TO cord-010119-t1x9gknd 7973 14 have have VB cord-010119-t1x9gknd 7973 15 Kell Kell NNP cord-010119-t1x9gknd 7973 16 null null JJ cord-010119-t1x9gknd 7973 17 and and CC cord-010119-t1x9gknd 7973 18 Sc sc JJ cord-010119-t1x9gknd 7973 19 null null JJ cord-010119-t1x9gknd 7973 20 phenotypes phenotype NNS cord-010119-t1x9gknd 7973 21 , , , cord-010119-t1x9gknd 7973 22 a a DT cord-010119-t1x9gknd 7973 23 search search NN cord-010119-t1x9gknd 7973 24 for for IN cord-010119-t1x9gknd 7973 25 K K NNP cord-010119-t1x9gknd 7973 26 o o NN cord-010119-t1x9gknd 7973 27 , , , cord-010119-t1x9gknd 7974 1 and/or and/or CC cord-010119-t1x9gknd 7974 2 Sc:21,23 sc:21,23 XX cord-010119-t1x9gknd 7975 1 RBC RBC NNP cord-010119-t1x9gknd 7975 2 units unit NNS cord-010119-t1x9gknd 7975 3 would would MD cord-010119-t1x9gknd 7975 4 be be VB cord-010119-t1x9gknd 7975 5 performed perform VBN cord-010119-t1x9gknd 7975 6 and and CC cord-010119-t1x9gknd 7975 7 we -PRON- PRP cord-010119-t1x9gknd 7975 8 would would MD cord-010119-t1x9gknd 7975 9 not not RB cord-010119-t1x9gknd 7975 10 have have VB cord-010119-t1x9gknd 7975 11 been be VBN cord-010119-t1x9gknd 7975 12 prompted prompt VBN cord-010119-t1x9gknd 7975 13 to to TO cord-010119-t1x9gknd 7975 14 re re VB cord-010119-t1x9gknd 7975 15 - - VB cord-010119-t1x9gknd 7975 16 type type VB cord-010119-t1x9gknd 7975 17 her -PRON- PRP$ cord-010119-t1x9gknd 7975 18 RBCs rbc NNS cord-010119-t1x9gknd 7975 19 when when WRB cord-010119-t1x9gknd 7975 20 the the DT cord-010119-t1x9gknd 7975 21 DAT DAT NNP cord-010119-t1x9gknd 7975 22 was be VBD cord-010119-t1x9gknd 7975 23 negative negative JJ cord-010119-t1x9gknd 7975 24 . . . cord-010119-t1x9gknd 7976 1 Background Background NNP cord-010119-t1x9gknd 7976 2 / / SYM cord-010119-t1x9gknd 7976 3 Case Case NNP cord-010119-t1x9gknd 7976 4 Studies Studies NNPS cord-010119-t1x9gknd 7977 1 : : : cord-010119-t1x9gknd 7977 2 Anti Anti NNP cord-010119-t1x9gknd 7977 3 - - NNP cord-010119-t1x9gknd 7977 4 Jka Jka NNP cord-010119-t1x9gknd 7977 5 is be VBZ cord-010119-t1x9gknd 7977 6 a a DT cord-010119-t1x9gknd 7977 7 common common JJ cord-010119-t1x9gknd 7977 8 antibody antibody NN cord-010119-t1x9gknd 7977 9 identified identify VBN cord-010119-t1x9gknd 7977 10 in in IN cord-010119-t1x9gknd 7977 11 the the DT cord-010119-t1x9gknd 7977 12 blood blood NN cord-010119-t1x9gknd 7977 13 bank bank NN cord-010119-t1x9gknd 7977 14 and and CC cord-010119-t1x9gknd 7977 15 providing provide VBG cord-010119-t1x9gknd 7977 16 phenotypically phenotypically RB cord-010119-t1x9gknd 7977 17 characterized characterize VBN cord-010119-t1x9gknd 7977 18 red red JJ cord-010119-t1x9gknd 7977 19 cells cell NNS cord-010119-t1x9gknd 7977 20 lacking lack VBG cord-010119-t1x9gknd 7977 21 this this DT cord-010119-t1x9gknd 7977 22 antigen antigen NN cord-010119-t1x9gknd 7977 23 is be VBZ cord-010119-t1x9gknd 7977 24 important important JJ cord-010119-t1x9gknd 7977 25 in in IN cord-010119-t1x9gknd 7977 26 avoiding avoid VBG cord-010119-t1x9gknd 7977 27 an an DT cord-010119-t1x9gknd 7977 28 acute acute JJ cord-010119-t1x9gknd 7977 29 or or CC cord-010119-t1x9gknd 7977 30 delayed delayed JJ cord-010119-t1x9gknd 7977 31 hemolytic hemolytic JJ cord-010119-t1x9gknd 7977 32 transfusion transfusion NN cord-010119-t1x9gknd 7977 33 reaction reaction NN cord-010119-t1x9gknd 7977 34 . . . cord-010119-t1x9gknd 7978 1 In in IN cord-010119-t1x9gknd 7978 2 nearly nearly RB cord-010119-t1x9gknd 7978 3 all all DT cord-010119-t1x9gknd 7978 4 cases case NNS cord-010119-t1x9gknd 7978 5 , , , cord-010119-t1x9gknd 7978 6 this this DT cord-010119-t1x9gknd 7978 7 antibody antibody NN cord-010119-t1x9gknd 7978 8 is be VBZ cord-010119-t1x9gknd 7978 9 identified identify VBN cord-010119-t1x9gknd 7978 10 in in IN cord-010119-t1x9gknd 7978 11 the the DT cord-010119-t1x9gknd 7978 12 context context NN cord-010119-t1x9gknd 7978 13 of of IN cord-010119-t1x9gknd 7978 14 a a DT cord-010119-t1x9gknd 7978 15 phenotypically phenotypically RB cord-010119-t1x9gknd 7978 16 homozygous homozygous JJ cord-010119-t1x9gknd 7978 17 Jkb Jkb NNP cord-010119-t1x9gknd 7978 18 patient patient NN cord-010119-t1x9gknd 7978 19 , , , cord-010119-t1x9gknd 7978 20 Jk(a Jk(a NNP cord-010119-t1x9gknd 7978 21 - - HYPH cord-010119-t1x9gknd 7978 22 b1 b1 NNP cord-010119-t1x9gknd 7978 23 ) ) -RRB- cord-010119-t1x9gknd 7978 24 . . . cord-010119-t1x9gknd 7979 1 Other other JJ cord-010119-t1x9gknd 7979 2 scenarios scenario NNS cord-010119-t1x9gknd 7979 3 are be VBP cord-010119-t1x9gknd 7979 4 quite quite RB cord-010119-t1x9gknd 7979 5 rare rare JJ cord-010119-t1x9gknd 7979 6 . . . cord-010119-t1x9gknd 7980 1 We -PRON- PRP cord-010119-t1x9gknd 7980 2 present present VBP cord-010119-t1x9gknd 7980 3 two two CD cord-010119-t1x9gknd 7980 4 cases case NNS cord-010119-t1x9gknd 7980 5 of of IN cord-010119-t1x9gknd 7980 6 anti anti JJ cord-010119-t1x9gknd 7980 7 - - JJ cord-010119-t1x9gknd 7980 8 Jka Jka NNP cord-010119-t1x9gknd 7980 9 in in IN cord-010119-t1x9gknd 7980 10 which which WDT cord-010119-t1x9gknd 7980 11 this this DT cord-010119-t1x9gknd 7980 12 phenotype phenotype NN cord-010119-t1x9gknd 7980 13 was be VBD cord-010119-t1x9gknd 7980 14 not not RB cord-010119-t1x9gknd 7980 15 observed observe VBN cord-010119-t1x9gknd 7980 16 . . . cord-010119-t1x9gknd 7981 1 Study Study NNP cord-010119-t1x9gknd 7981 2 Design Design NNP cord-010119-t1x9gknd 7981 3 / / SYM cord-010119-t1x9gknd 7981 4 Method method NN cord-010119-t1x9gknd 7981 5 : : : cord-010119-t1x9gknd 7982 1 Patient Patient NNP cord-010119-t1x9gknd 7982 2 A A NNP cord-010119-t1x9gknd 7982 3 is be VBZ cord-010119-t1x9gknd 7982 4 a a DT cord-010119-t1x9gknd 7982 5 55-year 55-year JJ cord-010119-t1x9gknd 7982 6 - - HYPH cord-010119-t1x9gknd 7982 7 old old JJ cord-010119-t1x9gknd 7982 8 multiparous multiparous JJ cord-010119-t1x9gknd 7982 9 female female NN cord-010119-t1x9gknd 7982 10 with with IN cord-010119-t1x9gknd 7982 11 no no DT cord-010119-t1x9gknd 7982 12 known know VBN cord-010119-t1x9gknd 7982 13 transfusion transfusion NN cord-010119-t1x9gknd 7982 14 history history NN cord-010119-t1x9gknd 7982 15 . . . cord-010119-t1x9gknd 7983 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7983 2 blood blood NN cord-010119-t1x9gknd 7983 3 typed type VBN cord-010119-t1x9gknd 7983 4 as as IN cord-010119-t1x9gknd 7983 5 O o UH cord-010119-t1x9gknd 7983 6 positive positive JJ cord-010119-t1x9gknd 7983 7 with with IN cord-010119-t1x9gknd 7983 8 a a DT cord-010119-t1x9gknd 7983 9 positive positive JJ cord-010119-t1x9gknd 7983 10 antibody antibody NN cord-010119-t1x9gknd 7983 11 screen screen NN cord-010119-t1x9gknd 7983 12 , , , cord-010119-t1x9gknd 7983 13 negative negative JJ cord-010119-t1x9gknd 7983 14 DAT DAT NNP cord-010119-t1x9gknd 7983 15 , , , cord-010119-t1x9gknd 7983 16 and and CC cord-010119-t1x9gknd 7983 17 a a DT cord-010119-t1x9gknd 7983 18 clearly clearly RB cord-010119-t1x9gknd 7983 19 identified identify VBN cord-010119-t1x9gknd 7983 20 anti anti JJ cord-010119-t1x9gknd 7983 21 - - NNP cord-010119-t1x9gknd 7983 22 Jka Jka NNP cord-010119-t1x9gknd 7983 23 in in IN cord-010119-t1x9gknd 7983 24 plasma plasma NN cord-010119-t1x9gknd 7983 25 . . . cord-010119-t1x9gknd 7984 1 The the DT cord-010119-t1x9gknd 7984 2 patient patient NN cord-010119-t1x9gknd 7984 3 phenotyped phenotype VBN cord-010119-t1x9gknd 7984 4 as as IN cord-010119-t1x9gknd 7984 5 Jk(a Jk(a NNP cord-010119-t1x9gknd 7984 6 - - HYPH cord-010119-t1x9gknd 7984 7 b- b- NNP cord-010119-t1x9gknd 7984 8 ) ) -RRB- cord-010119-t1x9gknd 7984 9 . . . cord-010119-t1x9gknd 7985 1 Genotyping Genotyping NNP cord-010119-t1x9gknd 7985 2 revealed reveal VBD cord-010119-t1x9gknd 7985 3 the the DT cord-010119-t1x9gknd 7985 4 presence presence NN cord-010119-t1x9gknd 7985 5 of of IN cord-010119-t1x9gknd 7985 6 the the DT cord-010119-t1x9gknd 7985 7 JK*B JK*B NNP cord-010119-t1x9gknd 7985 8 allele allele NN cord-010119-t1x9gknd 7985 9 , , , cord-010119-t1x9gknd 7985 10 but but CC cord-010119-t1x9gknd 7985 11 not not RB cord-010119-t1x9gknd 7985 12 the the DT cord-010119-t1x9gknd 7985 13 JK*A JK*A NNP cord-010119-t1x9gknd 7985 14 allele allele NN cord-010119-t1x9gknd 7985 15 . . . cord-010119-t1x9gknd 7986 1 Complete complete JJ cord-010119-t1x9gknd 7986 2 sequencing sequencing NN cord-010119-t1x9gknd 7986 3 of of IN cord-010119-t1x9gknd 7986 4 the the DT cord-010119-t1x9gknd 7986 5 JK JK NNP cord-010119-t1x9gknd 7986 6 gene gene NN cord-010119-t1x9gknd 7986 7 showed show VBD cord-010119-t1x9gknd 7986 8 an an DT cord-010119-t1x9gknd 7986 9 intron intron NN cord-010119-t1x9gknd 7986 10 5 5 CD cord-010119-t1x9gknd 7986 11 polymorphism polymorphism NN cord-010119-t1x9gknd 7986 12 in in IN cord-010119-t1x9gknd 7986 13 homozygosity homozygosity NN cord-010119-t1x9gknd 7986 14 . . . cord-010119-t1x9gknd 7987 1 Specifically specifically RB cord-010119-t1x9gknd 7987 2 , , , cord-010119-t1x9gknd 7987 3 the the DT cord-010119-t1x9gknd 7987 4 patient patient NN cord-010119-t1x9gknd 7987 5 showed show VBD cord-010119-t1x9gknd 7987 6 a a DT cord-010119-t1x9gknd 7987 7 JK*B(IVS5 JK*B(IVS5 VBN cord-010119-t1x9gknd 7987 8 - - HYPH cord-010119-t1x9gknd 7987 9 1A)genotype 1a)genotype CD cord-010119-t1x9gknd 7987 10 , , , cord-010119-t1x9gknd 7987 11 associated associate VBN cord-010119-t1x9gknd 7987 12 with with IN cord-010119-t1x9gknd 7987 13 a a DT cord-010119-t1x9gknd 7987 14 Jkb Jkb NNP cord-010119-t1x9gknd 7987 15 null null JJ cord-010119-t1x9gknd 7987 16 phenotype phenotype NN cord-010119-t1x9gknd 7987 17 . . . cord-010119-t1x9gknd 7988 1 Anti anti JJ cord-010119-t1x9gknd 7988 2 Jk3 Jk3 NNS cord-010119-t1x9gknd 7988 3 was be VBD cord-010119-t1x9gknd 7988 4 not not RB cord-010119-t1x9gknd 7988 5 identified identify VBN cord-010119-t1x9gknd 7988 6 . . . cord-010119-t1x9gknd 7989 1 The the DT cord-010119-t1x9gknd 7989 2 conclusion conclusion NN cord-010119-t1x9gknd 7989 3 was be VBD cord-010119-t1x9gknd 7989 4 an an DT cord-010119-t1x9gknd 7989 5 allo allo VB cord-010119-t1x9gknd 7989 6 - - HYPH cord-010119-t1x9gknd 7989 7 anti anti NN cord-010119-t1x9gknd 7989 8 - - NNP cord-010119-t1x9gknd 7989 9 Jka Jka NNP cord-010119-t1x9gknd 7989 10 in in IN cord-010119-t1x9gknd 7989 11 a a DT cord-010119-t1x9gknd 7989 12 Jk Jk NNP cord-010119-t1x9gknd 7989 13 null null JJ cord-010119-t1x9gknd 7989 14 patient patient NN cord-010119-t1x9gknd 7989 15 . . . cord-010119-t1x9gknd 7990 1 The the DT cord-010119-t1x9gknd 7990 2 patient patient NN cord-010119-t1x9gknd 7990 3 did do VBD cord-010119-t1x9gknd 7990 4 not not RB cord-010119-t1x9gknd 7990 5 receive receive VB cord-010119-t1x9gknd 7990 6 any any DT cord-010119-t1x9gknd 7990 7 transfusions transfusion NNS cord-010119-t1x9gknd 7990 8 . . . cord-010119-t1x9gknd 7991 1 Patient Patient NNP cord-010119-t1x9gknd 7991 2 B B NNP cord-010119-t1x9gknd 7991 3 is be VBZ cord-010119-t1x9gknd 7991 4 a a DT cord-010119-t1x9gknd 7991 5 multiply multiply NN cord-010119-t1x9gknd 7991 6 transfused transfuse VBN cord-010119-t1x9gknd 7991 7 64 64 CD cord-010119-t1x9gknd 7991 8 old old JJ cord-010119-t1x9gknd 7991 9 female female NN cord-010119-t1x9gknd 7991 10 . . . cord-010119-t1x9gknd 7992 1 Her -PRON- PRP$ cord-010119-t1x9gknd 7992 2 blood blood NN cord-010119-t1x9gknd 7992 3 typed type VBN cord-010119-t1x9gknd 7992 4 as as IN cord-010119-t1x9gknd 7992 5 A a DT cord-010119-t1x9gknd 7992 6 positive positive JJ cord-010119-t1x9gknd 7992 7 with with IN cord-010119-t1x9gknd 7992 8 a a DT cord-010119-t1x9gknd 7992 9 positive positive JJ cord-010119-t1x9gknd 7992 10 DAT dat NN cord-010119-t1x9gknd 7992 11 and and CC cord-010119-t1x9gknd 7992 12 antibody antibody NN cord-010119-t1x9gknd 7992 13 screen screen NN cord-010119-t1x9gknd 7992 14 . . . cord-010119-t1x9gknd 7993 1 Both both DT cord-010119-t1x9gknd 7993 2 the the DT cord-010119-t1x9gknd 7993 3 plasma plasma NN cord-010119-t1x9gknd 7993 4 and and CC cord-010119-t1x9gknd 7993 5 eluate eluate NN cord-010119-t1x9gknd 7993 6 revealed reveal VBD cord-010119-t1x9gknd 7993 7 an an DT cord-010119-t1x9gknd 7993 8 anti anti JJ cord-010119-t1x9gknd 7993 9 - - NN cord-010119-t1x9gknd 7993 10 Jka Jka NNP cord-010119-t1x9gknd 7993 11 . . . cord-010119-t1x9gknd 7994 1 Despite despite IN cord-010119-t1x9gknd 7994 2 the the DT cord-010119-t1x9gknd 7994 3 recent recent JJ cord-010119-t1x9gknd 7994 4 transfusion transfusion NN cord-010119-t1x9gknd 7994 5 , , , cord-010119-t1x9gknd 7994 6 the the DT cord-010119-t1x9gknd 7994 7 patient patient NN cord-010119-t1x9gknd 7994 8 phenotyped phenotype VBZ cord-010119-t1x9gknd 7994 9 as as IN cord-010119-t1x9gknd 7994 10 Jk(a1 Jk(a1 NNP cord-010119-t1x9gknd 7994 11 ) ) -RRB- cord-010119-t1x9gknd 7995 1 41 41 CD cord-010119-t1x9gknd 7995 2 and and CC cord-010119-t1x9gknd 7995 3 Jk(b1 Jk(b1 NNP cord-010119-t1x9gknd 7995 4 ) ) -RRB- cord-010119-t1x9gknd 7995 5 21 21 CD cord-010119-t1x9gknd 7995 6 . . . cord-010119-t1x9gknd 7996 1 Genotyping Genotyping NNP cord-010119-t1x9gknd 7996 2 showed show VBD cord-010119-t1x9gknd 7996 3 the the DT cord-010119-t1x9gknd 7996 4 presence presence NN cord-010119-t1x9gknd 7996 5 of of IN cord-010119-t1x9gknd 7996 6 both both CC cord-010119-t1x9gknd 7996 7 JK*A JK*A NNP cord-010119-t1x9gknd 7996 8 and and CC cord-010119-t1x9gknd 7996 9 JK*Balleles JK*Balleles NNPS cord-010119-t1x9gknd 7996 10 . . . cord-010119-t1x9gknd 7997 1 Whole whole JJ cord-010119-t1x9gknd 7997 2 gene gene NN cord-010119-t1x9gknd 7997 3 sequencing sequencing NN cord-010119-t1x9gknd 7997 4 was be VBD cord-010119-t1x9gknd 7997 5 not not RB cord-010119-t1x9gknd 7997 6 performed perform VBN cord-010119-t1x9gknd 7997 7 . . . cord-010119-t1x9gknd 7998 1 There there EX cord-010119-t1x9gknd 7998 2 was be VBD cord-010119-t1x9gknd 7998 3 no no DT cord-010119-t1x9gknd 7998 4 hematologic hematologic JJ cord-010119-t1x9gknd 7998 5 or or CC cord-010119-t1x9gknd 7998 6 biochemical biochemical JJ cord-010119-t1x9gknd 7998 7 evidence evidence NN cord-010119-t1x9gknd 7998 8 of of IN cord-010119-t1x9gknd 7998 9 hemolysis hemolysis NN cord-010119-t1x9gknd 7998 10 . . . cord-010119-t1x9gknd 7999 1 The the DT cord-010119-t1x9gknd 7999 2 patient patient NN cord-010119-t1x9gknd 7999 3 was be VBD cord-010119-t1x9gknd 7999 4 considered consider VBN cord-010119-t1x9gknd 7999 5 to to TO cord-010119-t1x9gknd 7999 6 have have VB cord-010119-t1x9gknd 7999 7 an an DT cord-010119-t1x9gknd 7999 8 auto auto NN cord-010119-t1x9gknd 7999 9 - - HYPH cord-010119-t1x9gknd 7999 10 anti anti NN cord-010119-t1x9gknd 7999 11 - - JJ cord-010119-t1x9gknd 7999 12 Jka Jka NNP cord-010119-t1x9gknd 7999 13 and and CC cord-010119-t1x9gknd 7999 14 Jka Jka NNP cord-010119-t1x9gknd 7999 15 negative negative JJ cord-010119-t1x9gknd 7999 16 cells cell NNS cord-010119-t1x9gknd 7999 17 used use VBN cord-010119-t1x9gknd 7999 18 for for IN cord-010119-t1x9gknd 7999 19 transfusion transfusion NN cord-010119-t1x9gknd 7999 20 . . . cord-010119-t1x9gknd 8000 1 Results result NNS cord-010119-t1x9gknd 8000 2 / / SYM cord-010119-t1x9gknd 8000 3 Findings finding NNS cord-010119-t1x9gknd 8000 4 : : : cord-010119-t1x9gknd 8001 1 Patients patient NNS cord-010119-t1x9gknd 8001 2 A A NNP cord-010119-t1x9gknd 8001 3 and and CC cord-010119-t1x9gknd 8001 4 B B NNP cord-010119-t1x9gknd 8001 5 both both DT cord-010119-t1x9gknd 8001 6 developed develop VBN cord-010119-t1x9gknd 8001 7 anti anti JJ cord-010119-t1x9gknd 8001 8 - - NN cord-010119-t1x9gknd 8001 9 Jka Jka NNP cord-010119-t1x9gknd 8001 10 while while IN cord-010119-t1x9gknd 8001 11 having have VBG cord-010119-t1x9gknd 8001 12 uncommon uncommon JJ cord-010119-t1x9gknd 8001 13 phenotypes phenotype NNS cord-010119-t1x9gknd 8001 14 / / SYM cord-010119-t1x9gknd 8001 15 genotypes genotype NNS cord-010119-t1x9gknd 8001 16 . . . cord-010119-t1x9gknd 8002 1 Conclusion conclusion NN cord-010119-t1x9gknd 8002 2 : : : cord-010119-t1x9gknd 8003 1 It -PRON- PRP cord-010119-t1x9gknd 8003 2 is be VBZ cord-010119-t1x9gknd 8003 3 common common JJ cord-010119-t1x9gknd 8003 4 for for IN cord-010119-t1x9gknd 8003 5 Jk Jk NNP cord-010119-t1x9gknd 8003 6 null null JJ cord-010119-t1x9gknd 8003 7 patients patient NNS cord-010119-t1x9gknd 8003 8 to to TO cord-010119-t1x9gknd 8003 9 develop develop VB cord-010119-t1x9gknd 8003 10 anti anti JJ cord-010119-t1x9gknd 8003 11 - - JJ cord-010119-t1x9gknd 8003 12 Jk3 Jk3 NNS cord-010119-t1x9gknd 8003 13 . . . cord-010119-t1x9gknd 8004 1 However however RB cord-010119-t1x9gknd 8004 2 , , , cord-010119-t1x9gknd 8004 3 we -PRON- PRP cord-010119-t1x9gknd 8004 4 speculate speculate VBP cord-010119-t1x9gknd 8004 5 that that IN cord-010119-t1x9gknd 8004 6 expression expression NN cord-010119-t1x9gknd 8004 7 of of IN cord-010119-t1x9gknd 8004 8 the the DT cord-010119-t1x9gknd 8004 9 Kidd Kidd NNP cord-010119-t1x9gknd 8004 10 glycoprotein glycoprotein NN cord-010119-t1x9gknd 8004 11 with with IN cord-010119-t1x9gknd 8004 12 the the DT cord-010119-t1x9gknd 8004 13 Jkb Jkb NNP cord-010119-t1x9gknd 8004 14 epitope epitope NN cord-010119-t1x9gknd 8004 15 was be VBD cord-010119-t1x9gknd 8004 16 below below IN cord-010119-t1x9gknd 8004 17 the the DT cord-010119-t1x9gknd 8004 18 threshold threshold NN cord-010119-t1x9gknd 8004 19 of of IN cord-010119-t1x9gknd 8004 20 serological serological JJ cord-010119-t1x9gknd 8004 21 detection detection NN cord-010119-t1x9gknd 8004 22 , , , cord-010119-t1x9gknd 8004 23 but but CC cord-010119-t1x9gknd 8004 24 enough enough JJ cord-010119-t1x9gknd 8004 25 to to TO cord-010119-t1x9gknd 8004 26 prevent prevent VB cord-010119-t1x9gknd 8004 27 the the DT cord-010119-t1x9gknd 8004 28 formation formation NN cord-010119-t1x9gknd 8004 29 of of IN cord-010119-t1x9gknd 8004 30 anti anti JJ cord-010119-t1x9gknd 8004 31 - - JJ cord-010119-t1x9gknd 8004 32 Jk3 jk3 JJ cord-010119-t1x9gknd 8004 33 or or CC cord-010119-t1x9gknd 8004 34 anti anti NNS cord-010119-t1x9gknd 8004 35 - - NN cord-010119-t1x9gknd 8004 36 Jkb Jkb NNP cord-010119-t1x9gknd 8004 37 . . . cord-010119-t1x9gknd 8005 1 Auto auto NN cord-010119-t1x9gknd 8005 2 - - HYPH cord-010119-t1x9gknd 8005 3 anti anti NN cord-010119-t1x9gknd 8005 4 - - JJ cord-010119-t1x9gknd 8005 5 Jka Jka NNP cord-010119-t1x9gknd 8005 6 is be VBZ cord-010119-t1x9gknd 8005 7 usually usually RB cord-010119-t1x9gknd 8005 8 reported report VBN cord-010119-t1x9gknd 8005 9 in in IN cord-010119-t1x9gknd 8005 10 the the DT cord-010119-t1x9gknd 8005 11 context context NN cord-010119-t1x9gknd 8005 12 of of IN cord-010119-t1x9gknd 8005 13 an an DT cord-010119-t1x9gknd 8005 14 active active JJ cord-010119-t1x9gknd 8005 15 hemolytic hemolytic JJ cord-010119-t1x9gknd 8005 16 process process NN cord-010119-t1x9gknd 8005 17 , , , cord-010119-t1x9gknd 8005 18 but but CC cord-010119-t1x9gknd 8005 19 Patient Patient NNP cord-010119-t1x9gknd 8005 20 B B NNP cord-010119-t1x9gknd 8005 21 illustrates illustrate VBZ cord-010119-t1x9gknd 8005 22 an an DT cord-010119-t1x9gknd 8005 23 auto auto NN cord-010119-t1x9gknd 8005 24 - - HYPH cord-010119-t1x9gknd 8005 25 anti anti NN cord-010119-t1x9gknd 8005 26 - - JJ cord-010119-t1x9gknd 8005 27 Jka Jka NNP cord-010119-t1x9gknd 8005 28 without without IN cord-010119-t1x9gknd 8005 29 hemolysis hemolysis NN cord-010119-t1x9gknd 8005 30 which which WDT cord-010119-t1x9gknd 8005 31 is be VBZ cord-010119-t1x9gknd 8005 32 more more RBR cord-010119-t1x9gknd 8005 33 commonly commonly RB cord-010119-t1x9gknd 8005 34 observed observe VBN cord-010119-t1x9gknd 8005 35 with with IN cord-010119-t1x9gknd 8005 36 autoantibodies autoantibody NNS cord-010119-t1x9gknd 8005 37 exhibiting exhibit VBG cord-010119-t1x9gknd 8005 38 specificity specificity NN cord-010119-t1x9gknd 8005 39 for for IN cord-010119-t1x9gknd 8005 40 Rh Rh NNP cord-010119-t1x9gknd 8005 41 epitopes epitope NNS cord-010119-t1x9gknd 8005 42 . . . cord-010119-t1x9gknd 8006 1 These these DT cord-010119-t1x9gknd 8006 2 rare rare JJ cord-010119-t1x9gknd 8006 3 cases case NNS cord-010119-t1x9gknd 8006 4 of of IN cord-010119-t1x9gknd 8006 5 anti anti JJ cord-010119-t1x9gknd 8006 6 - - JJ cord-010119-t1x9gknd 8006 7 Jka Jka NNP cord-010119-t1x9gknd 8006 8 require require VB cord-010119-t1x9gknd 8006 9 phenotypic phenotypic JJ cord-010119-t1x9gknd 8006 10 and and CC cord-010119-t1x9gknd 8006 11 genetic genetic JJ cord-010119-t1x9gknd 8006 12 analysis analysis NN cord-010119-t1x9gknd 8006 13 for for IN cord-010119-t1x9gknd 8006 14 the the DT cord-010119-t1x9gknd 8006 15 Jkb Jkb NNP cord-010119-t1x9gknd 8006 16 epitope epitope NN cord-010119-t1x9gknd 8006 17 and and CC cord-010119-t1x9gknd 8006 18 JK*B jk*b DT cord-010119-t1x9gknd 8006 19 allele allele NN cord-010119-t1x9gknd 8006 20 respectively respectively RB cord-010119-t1x9gknd 8006 21 , , , cord-010119-t1x9gknd 8006 22 and and CC cord-010119-t1x9gknd 8006 23 in in IN cord-010119-t1x9gknd 8006 24 more more JJR cord-010119-t1x9gknd 8006 25 complex complex JJ cord-010119-t1x9gknd 8006 26 cases case NNS cord-010119-t1x9gknd 8006 27 whole whole JJ cord-010119-t1x9gknd 8006 28 gene gene NN cord-010119-t1x9gknd 8006 29 sequencing sequencing NN cord-010119-t1x9gknd 8006 30 . . . cord-010119-t1x9gknd 8007 1 Background Background NNP cord-010119-t1x9gknd 8007 2 / / SYM cord-010119-t1x9gknd 8007 3 Case Case NNP cord-010119-t1x9gknd 8007 4 Studies Studies NNPS cord-010119-t1x9gknd 8007 5 : : : cord-010119-t1x9gknd 8007 6 Donor donor NN cord-010119-t1x9gknd 8007 7 genotyping genotyping NN cord-010119-t1x9gknd 8007 8 for for IN cord-010119-t1x9gknd 8007 9 red red JJ cord-010119-t1x9gknd 8007 10 blood blood NN cord-010119-t1x9gknd 8007 11 cell cell NN cord-010119-t1x9gknd 8007 12 antigens antigen NNS cord-010119-t1x9gknd 8007 13 has have VBZ cord-010119-t1x9gknd 8007 14 become become VBN cord-010119-t1x9gknd 8007 15 common common JJ cord-010119-t1x9gknd 8007 16 practice practice NN cord-010119-t1x9gknd 8007 17 in in IN cord-010119-t1x9gknd 8007 18 many many JJ cord-010119-t1x9gknd 8007 19 blood blood NN cord-010119-t1x9gknd 8007 20 bank bank NN cord-010119-t1x9gknd 8007 21 laboratories laboratory NNS cord-010119-t1x9gknd 8007 22 . . . cord-010119-t1x9gknd 8008 1 Package package NN cord-010119-t1x9gknd 8008 2 inserts insert NNS cord-010119-t1x9gknd 8008 3 for for IN cord-010119-t1x9gknd 8008 4 commercial commercial JJ cord-010119-t1x9gknd 8008 5 assays assay NNS cord-010119-t1x9gknd 8008 6 indicate indicate VBP cord-010119-t1x9gknd 8008 7 false false JJ cord-010119-t1x9gknd 8008 8 negative negative JJ cord-010119-t1x9gknd 8008 9 results result NNS cord-010119-t1x9gknd 8008 10 may may MD cord-010119-t1x9gknd 8008 11 be be VB cord-010119-t1x9gknd 8008 12 generated generate VBN cord-010119-t1x9gknd 8008 13 when when WRB cord-010119-t1x9gknd 8008 14 unexpected unexpected JJ cord-010119-t1x9gknd 8008 15 rare rare JJ cord-010119-t1x9gknd 8008 16 mutations mutation NNS cord-010119-t1x9gknd 8008 17 affect affect VBP cord-010119-t1x9gknd 8008 18 primer primer NN cord-010119-t1x9gknd 8008 19 or or CC cord-010119-t1x9gknd 8008 20 probe probe NN cord-010119-t1x9gknd 8008 21 binding binding NN cord-010119-t1x9gknd 8008 22 and and CC cord-010119-t1x9gknd 8008 23 cause cause VB cord-010119-t1x9gknd 8008 24 allele allele NN cord-010119-t1x9gknd 8008 25 dropout dropout NN cord-010119-t1x9gknd 8008 26 or or CC cord-010119-t1x9gknd 8008 27 failed fail VBN cord-010119-t1x9gknd 8008 28 amplification amplification NN cord-010119-t1x9gknd 8008 29 . . . cord-010119-t1x9gknd 8009 1 These these DT cord-010119-t1x9gknd 8009 2 outcomes outcome NNS cord-010119-t1x9gknd 8009 3 may may MD cord-010119-t1x9gknd 8009 4 go go VB cord-010119-t1x9gknd 8009 5 unrecognized unrecognized JJ cord-010119-t1x9gknd 8009 6 unless unless IN cord-010119-t1x9gknd 8009 7 serological serological JJ cord-010119-t1x9gknd 8009 8 results result NNS cord-010119-t1x9gknd 8009 9 are be VBP cord-010119-t1x9gknd 8009 10 available available JJ cord-010119-t1x9gknd 8009 11 for for IN cord-010119-t1x9gknd 8009 12 comparison comparison NN cord-010119-t1x9gknd 8009 13 . . . cord-010119-t1x9gknd 8010 1 Study Study NNP cord-010119-t1x9gknd 8010 2 Design Design NNP cord-010119-t1x9gknd 8010 3 / / SYM cord-010119-t1x9gknd 8010 4 Method method NN cord-010119-t1x9gknd 8010 5 : : : cord-010119-t1x9gknd 8011 1 A a DT cord-010119-t1x9gknd 8011 2 routine routine JJ cord-010119-t1x9gknd 8011 3 blood blood NN cord-010119-t1x9gknd 8011 4 donor donor NN cord-010119-t1x9gknd 8011 5 , , , cord-010119-t1x9gknd 8011 6 self self NN cord-010119-t1x9gknd 8011 7 - - HYPH cord-010119-t1x9gknd 8011 8 identified identify VBN cord-010119-t1x9gknd 8011 9 as as IN cord-010119-t1x9gknd 8011 10 African African NNP cord-010119-t1x9gknd 8011 11 American American NNP cord-010119-t1x9gknd 8011 12 , , , cord-010119-t1x9gknd 8011 13 was be VBD cord-010119-t1x9gknd 8011 14 selected select VBN cord-010119-t1x9gknd 8011 15 for for IN cord-010119-t1x9gknd 8011 16 red red JJ cord-010119-t1x9gknd 8011 17 blood blood NN cord-010119-t1x9gknd 8011 18 cell cell NN cord-010119-t1x9gknd 8011 19 genotyping genotyping NN cord-010119-t1x9gknd 8011 20 . . . cord-010119-t1x9gknd 8012 1 DNA DNA NNP cord-010119-t1x9gknd 8012 2 was be VBD cord-010119-t1x9gknd 8012 3 extracted extract VBN cord-010119-t1x9gknd 8012 4 and and CC cord-010119-t1x9gknd 8012 5 genotyping genotyping NN cord-010119-t1x9gknd 8012 6 was be VBD cord-010119-t1x9gknd 8012 7 performed perform VBN cord-010119-t1x9gknd 8012 8 using use VBG cord-010119-t1x9gknd 8012 9 two two CD cord-010119-t1x9gknd 8012 10 commercial commercial JJ cord-010119-t1x9gknd 8012 11 platforms platform NNS cord-010119-t1x9gknd 8012 12 160A 160a CD cord-010119-t1x9gknd 8012 13 TRANSFUSION transfusion NN cord-010119-t1x9gknd 8012 14 2017 2017 CD cord-010119-t1x9gknd 8012 15 Vol Vol NNP cord-010119-t1x9gknd 8012 16 . . . cord-010119-t1x9gknd 8013 1 57 57 CD cord-010119-t1x9gknd 8013 2 Supplement supplement NN cord-010119-t1x9gknd 8013 3 S3 s3 NN cord-010119-t1x9gknd 8013 4 ( ( -LRB- cord-010119-t1x9gknd 8013 5 PreciseType PreciseType NNP cord-010119-t1x9gknd 8013 6 , , , cord-010119-t1x9gknd 8013 7 BioArray BioArray NNP cord-010119-t1x9gknd 8013 8 , , , cord-010119-t1x9gknd 8013 9 Warren Warren NNP cord-010119-t1x9gknd 8013 10 NJ NJ NNP cord-010119-t1x9gknd 8013 11 ; ; : cord-010119-t1x9gknd 8013 12 IDCore IDCore NNP cord-010119-t1x9gknd 8013 13 XT XT NNP cord-010119-t1x9gknd 8013 14 , , , cord-010119-t1x9gknd 8013 15 Grifols Grifols NNP cord-010119-t1x9gknd 8013 16 , , , cord-010119-t1x9gknd 8013 17 Emeryville Emeryville NNP cord-010119-t1x9gknd 8013 18 , , , cord-010119-t1x9gknd 8013 19 CA CA NNP cord-010119-t1x9gknd 8013 20 ) ) -RRB- cord-010119-t1x9gknd 8013 21 . . . cord-010119-t1x9gknd 8014 1 Genotype genotype NN cord-010119-t1x9gknd 8014 2 results result NNS cord-010119-t1x9gknd 8014 3 were be VBD cord-010119-t1x9gknd 8014 4 compared compare VBN cord-010119-t1x9gknd 8014 5 to to IN cord-010119-t1x9gknd 8014 6 historical historical JJ cord-010119-t1x9gknd 8014 7 serological serological JJ cord-010119-t1x9gknd 8014 8 results result NNS cord-010119-t1x9gknd 8014 9 . . . cord-010119-t1x9gknd 8015 1 Discrepancies discrepancy NNS cord-010119-t1x9gknd 8015 2 were be VBD cord-010119-t1x9gknd 8015 3 resolved resolve VBN cord-010119-t1x9gknd 8015 4 by by IN cord-010119-t1x9gknd 8015 5 Sanger Sanger NNP cord-010119-t1x9gknd 8015 6 sequencing sequencing NN cord-010119-t1x9gknd 8015 7 ( ( -LRB- cord-010119-t1x9gknd 8015 8 Grifols Grifols NNP cord-010119-t1x9gknd 8015 9 IH IH NNP cord-010119-t1x9gknd 8015 10 , , , cord-010119-t1x9gknd 8015 11 San San NNP cord-010119-t1x9gknd 8015 12 Marcos Marcos NNP cord-010119-t1x9gknd 8015 13 , , , cord-010119-t1x9gknd 8015 14 TX TX NNP cord-010119-t1x9gknd 8015 15 ) ) -RRB- cord-010119-t1x9gknd 8015 16 . . . cord-010119-t1x9gknd 8016 1 Results/ Results/ . cord-010119-t1x9gknd 8017 1 Finding finding NN cord-010119-t1x9gknd 8017 2 : : : cord-010119-t1x9gknd 8018 1 Genotyping genotyping NN cord-010119-t1x9gknd 8018 2 results result NNS cord-010119-t1x9gknd 8018 3 showed show VBD cord-010119-t1x9gknd 8018 4 variants variant NNS cord-010119-t1x9gknd 8018 5 in in IN cord-010119-t1x9gknd 8018 6 both both CC cord-010119-t1x9gknd 8018 7 the the DT cord-010119-t1x9gknd 8018 8 Duffy Duffy NNP cord-010119-t1x9gknd 8018 9 ( ( -LRB- cord-010119-t1x9gknd 8018 10 FY FY NNP cord-010119-t1x9gknd 8018 11 ) ) -RRB- cord-010119-t1x9gknd 8018 12 and and CC cord-010119-t1x9gknd 8018 13 Kell Kell NNP cord-010119-t1x9gknd 8018 14 ( ( -LRB- cord-010119-t1x9gknd 8018 15 KEL KEL NNP cord-010119-t1x9gknd 8018 16 ) ) -RRB- cord-010119-t1x9gknd 8018 17 blood blood NN cord-010119-t1x9gknd 8018 18 group group NN cord-010119-t1x9gknd 8018 19 systems system NNS cord-010119-t1x9gknd 8018 20 . . . cord-010119-t1x9gknd 8019 1 The the DT cord-010119-t1x9gknd 8019 2 donor donor NN cord-010119-t1x9gknd 8019 3 's 's POS cord-010119-t1x9gknd 8019 4 genotype genotype NN cord-010119-t1x9gknd 8019 5 was be VBD cord-010119-t1x9gknd 8019 6 concordant concordant JJ cord-010119-t1x9gknd 8019 7 on on IN cord-010119-t1x9gknd 8019 8 both both DT cord-010119-t1x9gknd 8019 9 platforms platform NNS cord-010119-t1x9gknd 8019 10 , , , cord-010119-t1x9gknd 8019 11 FY*A FY*A NNP cord-010119-t1x9gknd 8019 12 / / SYM cord-010119-t1x9gknd 8019 13 FY*B_GATA FY*B_GATA NNP cord-010119-t1x9gknd 8019 14 , , , cord-010119-t1x9gknd 8019 15 KP*A KP*A NNP cord-010119-t1x9gknd 8019 16 / / SYM cord-010119-t1x9gknd 8019 17 KP*A KP*A NNP cord-010119-t1x9gknd 8019 18 , , , cord-010119-t1x9gknd 8019 19 for for IN cord-010119-t1x9gknd 8019 20 a a DT cord-010119-t1x9gknd 8019 21 predicted predict VBN cord-010119-t1x9gknd 8019 22 phenotype phenotype NN cord-010119-t1x9gknd 8019 23 : : : cord-010119-t1x9gknd 8019 24 Fy(a1b- Fy(a1b- NNP cord-010119-t1x9gknd 8019 25 ) ) -RRB- cord-010119-t1x9gknd 8019 26 ; ; : cord-010119-t1x9gknd 8019 27 Kp(a1b- Kp(a1b- NNP cord-010119-t1x9gknd 8019 28 ) ) -RRB- cord-010119-t1x9gknd 8019 29 . . . cord-010119-t1x9gknd 8020 1 When when WRB cord-010119-t1x9gknd 8020 2 genotype genotype NN cord-010119-t1x9gknd 8020 3 results result NNS cord-010119-t1x9gknd 8020 4 were be VBD cord-010119-t1x9gknd 8020 5 compared compare VBN cord-010119-t1x9gknd 8020 6 to to IN cord-010119-t1x9gknd 8020 7 historical historical JJ cord-010119-t1x9gknd 8020 8 serology serology NN cord-010119-t1x9gknd 8020 9 , , , cord-010119-t1x9gknd 8020 10 it -PRON- PRP cord-010119-t1x9gknd 8020 11 was be VBD cord-010119-t1x9gknd 8020 12 noted note VBN cord-010119-t1x9gknd 8020 13 that that IN cord-010119-t1x9gknd 8020 14 the the DT cord-010119-t1x9gknd 8020 15 donor donor NN cord-010119-t1x9gknd 8020 16 previously previously RB cord-010119-t1x9gknd 8020 17 typed type VBN cord-010119-t1x9gknd 8020 18 Fy(a- fy(a- CD cord-010119-t1x9gknd 8020 19 ) ) -RRB- cord-010119-t1x9gknd 8020 20 on on IN cord-010119-t1x9gknd 8020 21 3 3 CD cord-010119-t1x9gknd 8020 22 separate separate JJ cord-010119-t1x9gknd 8020 23 donations donation NNS cord-010119-t1x9gknd 8020 24 . . . cord-010119-t1x9gknd 8021 1 No no DT cord-010119-t1x9gknd 8021 2 previous previous JJ cord-010119-t1x9gknd 8021 3 Kpa Kpa NNP cord-010119-t1x9gknd 8021 4 or or CC cord-010119-t1x9gknd 8021 5 Kpb Kpb NNP cord-010119-t1x9gknd 8021 6 serotyping serotyping NN cord-010119-t1x9gknd 8021 7 was be VBD cord-010119-t1x9gknd 8021 8 available available JJ cord-010119-t1x9gknd 8021 9 . . . cord-010119-t1x9gknd 8022 1 Sequencing sequencing NN cord-010119-t1x9gknd 8022 2 of of IN cord-010119-t1x9gknd 8022 3 FY FY NNP cord-010119-t1x9gknd 8022 4 exon exon NN cord-010119-t1x9gknd 8022 5 2 2 CD cord-010119-t1x9gknd 8022 6 revealed reveal VBD cord-010119-t1x9gknd 8022 7 a a DT cord-010119-t1x9gknd 8022 8 287 287 CD cord-010119-t1x9gknd 8022 9 G g NN cord-010119-t1x9gknd 8022 10 > > XX cord-010119-t1x9gknd 8023 1 A a DT cord-010119-t1x9gknd 8023 2 mutation mutation NN cord-010119-t1x9gknd 8023 3 , , , cord-010119-t1x9gknd 8023 4 FY01*N.04 fy01*n.04 CD cord-010119-t1x9gknd 8023 5 , , , cord-010119-t1x9gknd 8023 6 known know VBN cord-010119-t1x9gknd 8023 7 to to TO cord-010119-t1x9gknd 8023 8 silence silence VB cord-010119-t1x9gknd 8023 9 Fya Fya NNP cord-010119-t1x9gknd 8023 10 . . . cord-010119-t1x9gknd 8024 1 Sequencing sequencing NN cord-010119-t1x9gknd 8024 2 of of IN cord-010119-t1x9gknd 8024 3 KEL KEL NNP cord-010119-t1x9gknd 8024 4 exons exon NNS cord-010119-t1x9gknd 8024 5 1 1 CD cord-010119-t1x9gknd 8024 6 - - SYM cord-010119-t1x9gknd 8024 7 19 19 CD cord-010119-t1x9gknd 8024 8 exposed expose VBD cord-010119-t1x9gknd 8024 9 a a DT cord-010119-t1x9gknd 8024 10 silent silent JJ cord-010119-t1x9gknd 8024 11 polymorphism polymorphism NN cord-010119-t1x9gknd 8024 12 in in IN cord-010119-t1x9gknd 8024 13 exon exon NN cord-010119-t1x9gknd 8024 14 8 8 CD cord-010119-t1x9gknd 8024 15 , , , cord-010119-t1x9gknd 8024 16 846 846 CD cord-010119-t1x9gknd 8024 17 G g NN cord-010119-t1x9gknd 8025 1 > > XX cord-010119-t1x9gknd 8026 1 C. C. NNP cord-010119-t1x9gknd 8027 1 This this DT cord-010119-t1x9gknd 8027 2 polymorphism polymorphism NN cord-010119-t1x9gknd 8027 3 causes cause VBZ cord-010119-t1x9gknd 8027 4 a a DT cord-010119-t1x9gknd 8027 5 dropout dropout NN cord-010119-t1x9gknd 8027 6 artifact artifact NN cord-010119-t1x9gknd 8027 7 yielding yield VBG cord-010119-t1x9gknd 8027 8 a a DT cord-010119-t1x9gknd 8027 9 false false JJ cord-010119-t1x9gknd 8027 10 negative negative JJ cord-010119-t1x9gknd 8027 11 Kpb kpb JJ cord-010119-t1x9gknd 8027 12 interpretation interpretation NN cord-010119-t1x9gknd 8027 13 . . . cord-010119-t1x9gknd 8028 1 Conclusion conclusion NN cord-010119-t1x9gknd 8028 2 : : : cord-010119-t1x9gknd 8029 1 The the DT cord-010119-t1x9gknd 8029 2 discrepant discrepant JJ cord-010119-t1x9gknd 8029 3 FY*A FY*A NNP cord-010119-t1x9gknd 8029 4 result result NN cord-010119-t1x9gknd 8029 5 , , , cord-010119-t1x9gknd 8029 6 as as RB cord-010119-t1x9gknd 8029 7 well well RB cord-010119-t1x9gknd 8029 8 as as IN cord-010119-t1x9gknd 8029 9 the the DT cord-010119-t1x9gknd 8029 10 unlikely unlikely JJ cord-010119-t1x9gknd 8029 11 Kp(b- kp(b- CD cord-010119-t1x9gknd 8029 12 ) ) -RRB- cord-010119-t1x9gknd 8029 13 type type NN cord-010119-t1x9gknd 8029 14 prompted prompt VBD cord-010119-t1x9gknd 8029 15 the the DT cord-010119-t1x9gknd 8029 16 request request NN cord-010119-t1x9gknd 8029 17 for for IN cord-010119-t1x9gknd 8029 18 sequencing sequencing NN cord-010119-t1x9gknd 8029 19 . . . cord-010119-t1x9gknd 8030 1 The the DT cord-010119-t1x9gknd 8030 2 rare rare JJ cord-010119-t1x9gknd 8030 3 FY01*N.04 fy01*n.04 NN cord-010119-t1x9gknd 8030 4 mutation mutation NN cord-010119-t1x9gknd 8030 5 has have VBZ cord-010119-t1x9gknd 8030 6 been be VBN cord-010119-t1x9gknd 8030 7 reported report VBN cord-010119-t1x9gknd 8030 8 in in IN cord-010119-t1x9gknd 8030 9 people people NNS cord-010119-t1x9gknd 8030 10 of of IN cord-010119-t1x9gknd 8030 11 Caucasian caucasian JJ cord-010119-t1x9gknd 8030 12 descent descent NN cord-010119-t1x9gknd 8030 13 . . . cord-010119-t1x9gknd 8031 1 This this DT cord-010119-t1x9gknd 8031 2 is be VBZ cord-010119-t1x9gknd 8031 3 the the DT cord-010119-t1x9gknd 8031 4 first first JJ cord-010119-t1x9gknd 8031 5 example example NN cord-010119-t1x9gknd 8031 6 of of IN cord-010119-t1x9gknd 8031 7 this this DT cord-010119-t1x9gknd 8031 8 FY FY NNP cord-010119-t1x9gknd 8031 9 mutation mutation NN cord-010119-t1x9gknd 8031 10 identified identify VBN cord-010119-t1x9gknd 8031 11 in in IN cord-010119-t1x9gknd 8031 12 this this DT cord-010119-t1x9gknd 8031 13 regional regional JJ cord-010119-t1x9gknd 8031 14 population population NN cord-010119-t1x9gknd 8031 15 . . . cord-010119-t1x9gknd 8032 1 The the DT cord-010119-t1x9gknd 8032 2 Kpb Kpb NNP cord-010119-t1x9gknd 8032 3 antigen antigen NN cord-010119-t1x9gknd 8032 4 is be VBZ cord-010119-t1x9gknd 8032 5 present present JJ cord-010119-t1x9gknd 8032 6 in in IN cord-010119-t1x9gknd 8032 7 nearly nearly RB cord-010119-t1x9gknd 8032 8 100 100 CD cord-010119-t1x9gknd 8032 9 % % NN cord-010119-t1x9gknd 8032 10 of of IN cord-010119-t1x9gknd 8032 11 all all DT cord-010119-t1x9gknd 8032 12 populations population NNS cord-010119-t1x9gknd 8032 13 . . . cord-010119-t1x9gknd 8033 1 However however RB cord-010119-t1x9gknd 8033 2 , , , cord-010119-t1x9gknd 8033 3 Kp(b- kp(b- LS cord-010119-t1x9gknd 8033 4 ) ) -RRB- cord-010119-t1x9gknd 8033 5 is be VBZ cord-010119-t1x9gknd 8033 6 most most RBS cord-010119-t1x9gknd 8033 7 frequently frequently RB cord-010119-t1x9gknd 8033 8 seen see VBN cord-010119-t1x9gknd 8033 9 in in IN cord-010119-t1x9gknd 8033 10 people people NNS cord-010119-t1x9gknd 8033 11 of of IN cord-010119-t1x9gknd 8033 12 Caucasian caucasian JJ cord-010119-t1x9gknd 8033 13 descent descent NN cord-010119-t1x9gknd 8033 14 . . . cord-010119-t1x9gknd 8034 1 To to IN cord-010119-t1x9gknd 8034 2 date date NN cord-010119-t1x9gknd 8034 3 , , , cord-010119-t1x9gknd 8034 4 64 64 CD cord-010119-t1x9gknd 8034 5 self self NN cord-010119-t1x9gknd 8034 6 - - HYPH cord-010119-t1x9gknd 8034 7 identified identify VBN cord-010119-t1x9gknd 8034 8 African african JJ cord-010119-t1x9gknd 8034 9 American american JJ cord-010119-t1x9gknd 8034 10 donors donor NNS cord-010119-t1x9gknd 8034 11 have have VBP cord-010119-t1x9gknd 8034 12 been be VBN cord-010119-t1x9gknd 8034 13 genotyped genotype VBN cord-010119-t1x9gknd 8034 14 as as IN cord-010119-t1x9gknd 8034 15 KP*A KP*A NNP cord-010119-t1x9gknd 8034 16 / / SYM cord-010119-t1x9gknd 8034 17 KP*B KP*B NNP cord-010119-t1x9gknd 8034 18 at at IN cord-010119-t1x9gknd 8034 19 this this DT cord-010119-t1x9gknd 8034 20 blood blood NN cord-010119-t1x9gknd 8034 21 center center NN cord-010119-t1x9gknd 8034 22 . . . cord-010119-t1x9gknd 8035 1 Given give VBN cord-010119-t1x9gknd 8035 2 the the DT cord-010119-t1x9gknd 8035 3 diversity diversity NN cord-010119-t1x9gknd 8035 4 of of IN cord-010119-t1x9gknd 8035 5 regional regional JJ cord-010119-t1x9gknd 8035 6 heterogeneity heterogeneity NN cord-010119-t1x9gknd 8035 7 , , , cord-010119-t1x9gknd 8035 8 it -PRON- PRP cord-010119-t1x9gknd 8035 9 is be VBZ cord-010119-t1x9gknd 8035 10 feasible feasible JJ cord-010119-t1x9gknd 8035 11 to to TO cord-010119-t1x9gknd 8035 12 identify identify VB cord-010119-t1x9gknd 8035 13 a a DT cord-010119-t1x9gknd 8035 14 Kp(b- kp(b- CD cord-010119-t1x9gknd 8035 15 ) ) -RRB- cord-010119-t1x9gknd 8035 16 donor donor NN cord-010119-t1x9gknd 8035 17 , , , cord-010119-t1x9gknd 8035 18 self self NN cord-010119-t1x9gknd 8035 19 - - HYPH cord-010119-t1x9gknd 8035 20 reporting reporting NN cord-010119-t1x9gknd 8035 21 as as IN cord-010119-t1x9gknd 8035 22 African African NNP cord-010119-t1x9gknd 8035 23 American American NNP cord-010119-t1x9gknd 8035 24 . . . cord-010119-t1x9gknd 8036 1 Red red JJ cord-010119-t1x9gknd 8036 2 blood blood NN cord-010119-t1x9gknd 8036 3 cell cell NN cord-010119-t1x9gknd 8036 4 genotyping genotyping NN cord-010119-t1x9gknd 8036 5 offers offer VBZ cord-010119-t1x9gknd 8036 6 an an DT cord-010119-t1x9gknd 8036 7 abundance abundance NN cord-010119-t1x9gknd 8036 8 of of IN cord-010119-t1x9gknd 8036 9 information information NN cord-010119-t1x9gknd 8036 10 , , , cord-010119-t1x9gknd 8036 11 but but CC cord-010119-t1x9gknd 8036 12 can can MD cord-010119-t1x9gknd 8036 13 not not RB cord-010119-t1x9gknd 8036 14 replace replace VB cord-010119-t1x9gknd 8036 15 serology serology NN cord-010119-t1x9gknd 8036 16 as as IN cord-010119-t1x9gknd 8036 17 the the DT cord-010119-t1x9gknd 8036 18 sole sole JJ cord-010119-t1x9gknd 8036 19 means mean NNS cord-010119-t1x9gknd 8036 20 of of IN cord-010119-t1x9gknd 8036 21 red red JJ cord-010119-t1x9gknd 8036 22 cell cell NN cord-010119-t1x9gknd 8036 23 antigen antigen NN cord-010119-t1x9gknd 8036 24 characterization characterization NN cord-010119-t1x9gknd 8036 25 . . . cord-010119-t1x9gknd 8037 1 Donor donor NN cord-010119-t1x9gknd 8037 2 ethnicity ethnicity NN cord-010119-t1x9gknd 8037 3 continues continue VBZ cord-010119-t1x9gknd 8037 4 to to TO cord-010119-t1x9gknd 8037 5 play play VB cord-010119-t1x9gknd 8037 6 a a DT cord-010119-t1x9gknd 8037 7 key key JJ cord-010119-t1x9gknd 8037 8 role role NN cord-010119-t1x9gknd 8037 9 in in IN cord-010119-t1x9gknd 8037 10 selection selection NN cord-010119-t1x9gknd 8037 11 for for IN cord-010119-t1x9gknd 8037 12 genotyping genotyping NN cord-010119-t1x9gknd 8037 13 and and CC cord-010119-t1x9gknd 8037 14 the the DT cord-010119-t1x9gknd 8037 15 search search NN cord-010119-t1x9gknd 8037 16 for for IN cord-010119-t1x9gknd 8037 17 rare rare JJ cord-010119-t1x9gknd 8037 18 and and CC cord-010119-t1x9gknd 8037 19 unusual unusual JJ cord-010119-t1x9gknd 8037 20 red red JJ cord-010119-t1x9gknd 8037 21 cell cell NN cord-010119-t1x9gknd 8037 22 types type NNS cord-010119-t1x9gknd 8037 23 . . . cord-010119-t1x9gknd 8038 1 In in IN cord-010119-t1x9gknd 8038 2 this this DT cord-010119-t1x9gknd 8038 3 case case NN cord-010119-t1x9gknd 8038 4 , , , cord-010119-t1x9gknd 8038 5 a a DT cord-010119-t1x9gknd 8038 6 donor donor NN cord-010119-t1x9gknd 8038 7 selected select VBN cord-010119-t1x9gknd 8038 8 for for IN cord-010119-t1x9gknd 8038 9 genotyping genotype VBG cord-010119-t1x9gknd 8038 10 based base VBN cord-010119-t1x9gknd 8038 11 on on IN cord-010119-t1x9gknd 8038 12 ethnicity ethnicity NN cord-010119-t1x9gknd 8038 13 was be VBD cord-010119-t1x9gknd 8038 14 initially initially RB cord-010119-t1x9gknd 8038 15 thought think VBN cord-010119-t1x9gknd 8038 16 to to TO cord-010119-t1x9gknd 8038 17 have have VB cord-010119-t1x9gknd 8038 18 2 2 CD cord-010119-t1x9gknd 8038 19 genetic genetic JJ cord-010119-t1x9gknd 8038 20 variants variant NNS cord-010119-t1x9gknd 8038 21 not not RB cord-010119-t1x9gknd 8038 22 previously previously RB cord-010119-t1x9gknd 8038 23 reported report VBN cord-010119-t1x9gknd 8038 24 in in IN cord-010119-t1x9gknd 8038 25 those those DT cord-010119-t1x9gknd 8038 26 of of IN cord-010119-t1x9gknd 8038 27 African african JJ cord-010119-t1x9gknd 8038 28 descent descent NN cord-010119-t1x9gknd 8038 29 . . . cord-010119-t1x9gknd 8039 1 Only only RB cord-010119-t1x9gknd 8039 2 1 1 CD cord-010119-t1x9gknd 8039 3 was be VBD cord-010119-t1x9gknd 8039 4 proven prove VBN cord-010119-t1x9gknd 8039 5 to to TO cord-010119-t1x9gknd 8039 6 be be VB cord-010119-t1x9gknd 8039 7 present present JJ cord-010119-t1x9gknd 8039 8 . . . cord-010119-t1x9gknd 8040 1 This this DT cord-010119-t1x9gknd 8040 2 case case NN cord-010119-t1x9gknd 8040 3 acts act VBZ cord-010119-t1x9gknd 8040 4 as as IN cord-010119-t1x9gknd 8040 5 a a DT cord-010119-t1x9gknd 8040 6 reminder reminder NN cord-010119-t1x9gknd 8040 7 that that IN cord-010119-t1x9gknd 8040 8 genotype genotype NN cord-010119-t1x9gknd 8040 9 limitations limitation NNS cord-010119-t1x9gknd 8040 10 must must MD cord-010119-t1x9gknd 8040 11 be be VB cord-010119-t1x9gknd 8040 12 considered consider VBN cord-010119-t1x9gknd 8040 13 even even RB cord-010119-t1x9gknd 8040 14 when when WRB cord-010119-t1x9gknd 8040 15 using use VBG cord-010119-t1x9gknd 8040 16 licensed license VBN cord-010119-t1x9gknd 8040 17 methodologies methodology NNS cord-010119-t1x9gknd 8040 18 . . . cord-010119-t1x9gknd 8041 1 This this DT cord-010119-t1x9gknd 8041 2 case case NN cord-010119-t1x9gknd 8041 3 report report NN cord-010119-t1x9gknd 8041 4 presents present VBZ cord-010119-t1x9gknd 8041 5 two two CD cord-010119-t1x9gknd 8041 6 group group NN cord-010119-t1x9gknd 8041 7 O o NN cord-010119-t1x9gknd 8041 8 pediatric pediatric JJ cord-010119-t1x9gknd 8041 9 patients patient NNS cord-010119-t1x9gknd 8041 10 who who WP cord-010119-t1x9gknd 8041 11 had have VBD cord-010119-t1x9gknd 8041 12 been be VBN cord-010119-t1x9gknd 8041 13 on on IN cord-010119-t1x9gknd 8041 14 enteral enteral JJ cord-010119-t1x9gknd 8041 15 feeds feed NNS cord-010119-t1x9gknd 8041 16 and and CC cord-010119-t1x9gknd 8041 17 had have VBD cord-010119-t1x9gknd 8041 18 absent absent JJ cord-010119-t1x9gknd 8041 19 / / SYM cord-010119-t1x9gknd 8041 20 weak weak JJ cord-010119-t1x9gknd 8041 21 anti anti NN cord-010119-t1x9gknd 8041 22 - - NN cord-010119-t1x9gknd 8041 23 B b NN cord-010119-t1x9gknd 8041 24 that that WDT cord-010119-t1x9gknd 8041 25 became become VBD cord-010119-t1x9gknd 8041 26 strong strong JJ cord-010119-t1x9gknd 8041 27 over over IN cord-010119-t1x9gknd 8041 28 time time NN cord-010119-t1x9gknd 8041 29 in in IN cord-010119-t1x9gknd 8041 30 patient patient NN cord-010119-t1x9gknd 8041 31 1 1 CD cord-010119-t1x9gknd 8041 32 . . . cord-010119-t1x9gknd 8042 1 Study Study NNP cord-010119-t1x9gknd 8042 2 Design Design NNP cord-010119-t1x9gknd 8042 3 / / SYM cord-010119-t1x9gknd 8042 4 Methods method NNS cord-010119-t1x9gknd 8042 5 : : : cord-010119-t1x9gknd 8042 6 Patient Patient NNP cord-010119-t1x9gknd 8042 7 1 1 CD cord-010119-t1x9gknd 8042 8 was be VBD cord-010119-t1x9gknd 8042 9 a a DT cord-010119-t1x9gknd 8042 10 7 7 CD cord-010119-t1x9gknd 8042 11 year year NN cord-010119-t1x9gknd 8042 12 - - HYPH cord-010119-t1x9gknd 8042 13 old old JJ cord-010119-t1x9gknd 8042 14 male male NN cord-010119-t1x9gknd 8042 15 born bear VBN cord-010119-t1x9gknd 8042 16 prematurely prematurely RB cord-010119-t1x9gknd 8042 17 with with IN cord-010119-t1x9gknd 8042 18 short short JJ cord-010119-t1x9gknd 8042 19 gut gut NN cord-010119-t1x9gknd 8042 20 syndrome syndrome NN cord-010119-t1x9gknd 8042 21 who who WP cord-010119-t1x9gknd 8042 22 underwent undergo VBD cord-010119-t1x9gknd 8042 23 a a DT cord-010119-t1x9gknd 8042 24 small small JJ cord-010119-t1x9gknd 8042 25 bowel bowel NN cord-010119-t1x9gknd 8042 26 and and CC cord-010119-t1x9gknd 8042 27 liver liver NN cord-010119-t1x9gknd 8042 28 transplant transplant NN cord-010119-t1x9gknd 8042 29 at at IN cord-010119-t1x9gknd 8042 30 3 3 CD cord-010119-t1x9gknd 8042 31 years year NNS cord-010119-t1x9gknd 8042 32 of of IN cord-010119-t1x9gknd 8042 33 age age NN cord-010119-t1x9gknd 8042 34 . . . cord-010119-t1x9gknd 8043 1 Anti Anti NNP cord-010119-t1x9gknd 8043 2 - - NNP cord-010119-t1x9gknd 8043 3 B B NNP cord-010119-t1x9gknd 8043 4 changed change VBD cord-010119-t1x9gknd 8043 5 from from IN cord-010119-t1x9gknd 8043 6 undetectable undetectable JJ cord-010119-t1x9gknd 8043 7 / / SYM cord-010119-t1x9gknd 8043 8 weak weak JJ cord-010119-t1x9gknd 8043 9 to to TO cord-010119-t1x9gknd 8043 10 strong strong JJ cord-010119-t1x9gknd 8043 11 at at IN cord-010119-t1x9gknd 8043 12 the the DT cord-010119-t1x9gknd 8043 13 age age NN cord-010119-t1x9gknd 8043 14 of of IN cord-010119-t1x9gknd 8043 15 7 7 CD cord-010119-t1x9gknd 8043 16 years year NNS cord-010119-t1x9gknd 8043 17 . . . cord-010119-t1x9gknd 8044 1 Patient Patient NNP cord-010119-t1x9gknd 8044 2 2 2 CD cord-010119-t1x9gknd 8044 3 was be VBD cord-010119-t1x9gknd 8044 4 a a DT cord-010119-t1x9gknd 8044 5 17 17 CD cord-010119-t1x9gknd 8044 6 month month NN cord-010119-t1x9gknd 8044 7 - - HYPH cord-010119-t1x9gknd 8044 8 old old JJ cord-010119-t1x9gknd 8044 9 female female NN cord-010119-t1x9gknd 8044 10 with with IN cord-010119-t1x9gknd 8044 11 a a DT cord-010119-t1x9gknd 8044 12 metabolic metabolic JJ cord-010119-t1x9gknd 8044 13 urea urea NN cord-010119-t1x9gknd 8044 14 cycle cycle NN cord-010119-t1x9gknd 8044 15 disorder disorder NN cord-010119-t1x9gknd 8044 16 who who WP cord-010119-t1x9gknd 8044 17 underwent undergo VBD cord-010119-t1x9gknd 8044 18 a a DT cord-010119-t1x9gknd 8044 19 liver liver NN cord-010119-t1x9gknd 8044 20 transplant transplant NN cord-010119-t1x9gknd 8044 21 . . . cord-010119-t1x9gknd 8045 1 Anti Anti NNP cord-010119-t1x9gknd 8045 2 - - NNP cord-010119-t1x9gknd 8045 3 B B NNP cord-010119-t1x9gknd 8045 4 was be VBD cord-010119-t1x9gknd 8045 5 0/11 0/11 CD cord-010119-t1x9gknd 8045 6 . . . cord-010119-t1x9gknd 8046 1 Both both DT cord-010119-t1x9gknd 8046 2 patients patient NNS cord-010119-t1x9gknd 8046 3 were be VBD cord-010119-t1x9gknd 8046 4 on on IN cord-010119-t1x9gknd 8046 5 total total JJ cord-010119-t1x9gknd 8046 6 parenteral parenteral JJ cord-010119-t1x9gknd 8046 7 nutrition nutrition NN cord-010119-t1x9gknd 8046 8 ( ( -LRB- cord-010119-t1x9gknd 8046 9 TPN TPN NNP cord-010119-t1x9gknd 8046 10 ) ) -RRB- cord-010119-t1x9gknd 8046 11 since since IN cord-010119-t1x9gknd 8046 12 birth birth NN cord-010119-t1x9gknd 8046 13 and and CC cord-010119-t1x9gknd 8046 14 had have VBD cord-010119-t1x9gknd 8046 15 strong strong JJ cord-010119-t1x9gknd 8046 16 anti anti JJ cord-010119-t1x9gknd 8046 17 - - JJ cord-010119-t1x9gknd 8046 18 A a JJ cord-010119-t1x9gknd 8046 19 and and CC cord-010119-t1x9gknd 8046 20 normal normal JJ cord-010119-t1x9gknd 8046 21 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 8046 22 testing testing NN cord-010119-t1x9gknd 8046 23 . . . cord-010119-t1x9gknd 8047 1 ABO ABO NNP cord-010119-t1x9gknd 8047 2 typing type VBG cord-010119-t1x9gknd 8047 3 with with IN cord-010119-t1x9gknd 8047 4 enhancing enhance VBG cord-010119-t1x9gknd 8047 5 techniques technique NNS cord-010119-t1x9gknd 8047 6 is be VBZ cord-010119-t1x9gknd 8047 7 presented present VBN cord-010119-t1x9gknd 8047 8 in in IN cord-010119-t1x9gknd 8047 9 Table Table NNP cord-010119-t1x9gknd 8047 10 1 1 CD cord-010119-t1x9gknd 8047 11 . . . cord-010119-t1x9gknd 8048 1 Results/ Results/ . cord-010119-t1x9gknd 8049 1 Findings finding NNS cord-010119-t1x9gknd 8049 2 : : : cord-010119-t1x9gknd 8050 1 Both both DT cord-010119-t1x9gknd 8050 2 patients patient NNS cord-010119-t1x9gknd 8050 3 typed type VBN cord-010119-t1x9gknd 8050 4 as as IN cord-010119-t1x9gknd 8050 5 group group NN cord-010119-t1x9gknd 8050 6 O o NN cord-010119-t1x9gknd 8050 7 on on IN cord-010119-t1x9gknd 8050 8 forward forward RB cord-010119-t1x9gknd 8050 9 typing typing NN cord-010119-t1x9gknd 8050 10 . . . cord-010119-t1x9gknd 8051 1 Anti Anti NNP cord-010119-t1x9gknd 8051 2 - - NNP cord-010119-t1x9gknd 8051 3 A A NNP cord-010119-t1x9gknd 8051 4 was be VBD cord-010119-t1x9gknd 8051 5 strong strong JJ cord-010119-t1x9gknd 8051 6 in in IN cord-010119-t1x9gknd 8051 7 both both DT cord-010119-t1x9gknd 8051 8 patients patient NNS cord-010119-t1x9gknd 8051 9 . . . cord-010119-t1x9gknd 8052 1 Anti Anti NNP cord-010119-t1x9gknd 8052 2 - - NN cord-010119-t1x9gknd 8052 3 B b NN cord-010119-t1x9gknd 8052 4 varied varied JJ cord-010119-t1x9gknd 8052 5 in in IN cord-010119-t1x9gknd 8052 6 strength strength NN cord-010119-t1x9gknd 8052 7 in in IN cord-010119-t1x9gknd 8052 8 patient patient NN cord-010119-t1x9gknd 8052 9 1 1 CD cord-010119-t1x9gknd 8052 10 with with IN cord-010119-t1x9gknd 8052 11 0 0 CD cord-010119-t1x9gknd 8052 12 - - HYPH cord-010119-t1x9gknd 8052 13 11 11 CD cord-010119-t1x9gknd 8052 14 reactions reaction NNS cord-010119-t1x9gknd 8052 15 up up IN cord-010119-t1x9gknd 8052 16 to to TO cord-010119-t1x9gknd 8052 17 7 7 CD cord-010119-t1x9gknd 8052 18 years year NNS cord-010119-t1x9gknd 8052 19 of of IN cord-010119-t1x9gknd 8052 20 age age NN cord-010119-t1x9gknd 8052 21 . . . cord-010119-t1x9gknd 8053 1 Thereafter thereafter RB cord-010119-t1x9gknd 8053 2 , , , cord-010119-t1x9gknd 8053 3 ABO ABO NNP cord-010119-t1x9gknd 8053 4 typing typing NN cord-010119-t1x9gknd 8053 5 showed show VBD cord-010119-t1x9gknd 8053 6 mainly mainly RB cord-010119-t1x9gknd 8053 7 strong strong JJ cord-010119-t1x9gknd 8053 8 anti anti JJ cord-010119-t1x9gknd 8053 9 - - JJ cord-010119-t1x9gknd 8053 10 B. B. NNP cord-010119-t1x9gknd 8053 11 Patient Patient NNP cord-010119-t1x9gknd 8053 12 2 2 CD cord-010119-t1x9gknd 8053 13 had have VBD cord-010119-t1x9gknd 8053 14 0/11 0/11 CD cord-010119-t1x9gknd 8053 15 anti anti JJ cord-010119-t1x9gknd 8053 16 - - JJ cord-010119-t1x9gknd 8053 17 B. b. JJ cord-010119-t1x9gknd 8053 18 Conclusion conclusion NN cord-010119-t1x9gknd 8053 19 : : : cord-010119-t1x9gknd 8053 20 Intestinal intestinal JJ cord-010119-t1x9gknd 8053 21 bacteria bacteria NNS cord-010119-t1x9gknd 8053 22 stimulates stimulate VBZ cord-010119-t1x9gknd 8053 23 production production NN cord-010119-t1x9gknd 8053 24 of of IN cord-010119-t1x9gknd 8053 25 anti anti JJ cord-010119-t1x9gknd 8053 26 - - JJ cord-010119-t1x9gknd 8053 27 A a NN cord-010119-t1x9gknd 8053 28 and and CC cord-010119-t1x9gknd 8053 29 -B. -b. IN cord-010119-t1x9gknd 8053 30 Unexpected unexpected JJ cord-010119-t1x9gknd 8053 31 changes change NNS cord-010119-t1x9gknd 8053 32 in in IN cord-010119-t1x9gknd 8053 33 anti anti JJ cord-010119-t1x9gknd 8053 34 - - NN cord-010119-t1x9gknd 8053 35 B b NN cord-010119-t1x9gknd 8053 36 that that WDT cord-010119-t1x9gknd 8053 37 caused cause VBD cord-010119-t1x9gknd 8053 38 ABO ABO NNP cord-010119-t1x9gknd 8053 39 discrepancies discrepancy NNS cord-010119-t1x9gknd 8053 40 are be VBP cord-010119-t1x9gknd 8053 41 reported report VBN cord-010119-t1x9gknd 8053 42 here here RB cord-010119-t1x9gknd 8053 43 for for IN cord-010119-t1x9gknd 8053 44 2 2 CD cord-010119-t1x9gknd 8053 45 children child NNS cord-010119-t1x9gknd 8053 46 on on IN cord-010119-t1x9gknd 8053 47 long long JJ cord-010119-t1x9gknd 8053 48 - - HYPH cord-010119-t1x9gknd 8053 49 term term NN cord-010119-t1x9gknd 8053 50 TPN TPN NNP cord-010119-t1x9gknd 8053 51 . . . cord-010119-t1x9gknd 8054 1 Patient patient NN cord-010119-t1x9gknd 8054 2 1 1 CD cord-010119-t1x9gknd 8054 3 had have VBD cord-010119-t1x9gknd 8054 4 absent absent JJ cord-010119-t1x9gknd 8054 5 / / SYM cord-010119-t1x9gknd 8054 6 weak weak JJ cord-010119-t1x9gknd 8054 7 anti anti JJ cord-010119-t1x9gknd 8054 8 - - JJ cord-010119-t1x9gknd 8054 9 B b NN cord-010119-t1x9gknd 8054 10 since since IN cord-010119-t1x9gknd 8054 11 birth birth NN cord-010119-t1x9gknd 8054 12 up up IN cord-010119-t1x9gknd 8054 13 to to TO cord-010119-t1x9gknd 8054 14 7 7 CD cord-010119-t1x9gknd 8054 15 years year NNS cord-010119-t1x9gknd 8054 16 of of IN cord-010119-t1x9gknd 8054 17 age age NN cord-010119-t1x9gknd 8054 18 , , , cord-010119-t1x9gknd 8054 19 then then RB cord-010119-t1x9gknd 8054 20 developed develop VBD cord-010119-t1x9gknd 8054 21 strong strong JJ cord-010119-t1x9gknd 8054 22 anti anti NNS cord-010119-t1x9gknd 8054 23 - - NN cord-010119-t1x9gknd 8054 24 B b NN cord-010119-t1x9gknd 8054 25 with with IN cord-010119-t1x9gknd 8054 26 no no DT cord-010119-t1x9gknd 8054 27 change change NN cord-010119-t1x9gknd 8054 28 in in IN cord-010119-t1x9gknd 8054 29 feeding feed VBG cord-010119-t1x9gknd 8054 30 regiment regiment NN cord-010119-t1x9gknd 8054 31 and and CC cord-010119-t1x9gknd 8054 32 medications medication NNS cord-010119-t1x9gknd 8054 33 . . . cord-010119-t1x9gknd 8055 1 Patient patient NN cord-010119-t1x9gknd 8055 2 2 2 CD cord-010119-t1x9gknd 8055 3 had have VBD cord-010119-t1x9gknd 8056 1 consistently consistently RB cord-010119-t1x9gknd 8056 2 strong strong JJ cord-010119-t1x9gknd 8056 3 anti anti JJ cord-010119-t1x9gknd 8056 4 - - JJ cord-010119-t1x9gknd 8056 5 A a NN cord-010119-t1x9gknd 8057 1 and and CC cord-010119-t1x9gknd 8057 2 absent absent JJ cord-010119-t1x9gknd 8057 3 / / SYM cord-010119-t1x9gknd 8057 4 weak weak JJ cord-010119-t1x9gknd 8057 5 anti anti JJ cord-010119-t1x9gknd 8057 6 - - JJ cord-010119-t1x9gknd 8057 7 B. B. NNP cord-010119-t1x9gknd 8057 8 These these DT cord-010119-t1x9gknd 8057 9 findings finding NNS cord-010119-t1x9gknd 8057 10 support support VBP cord-010119-t1x9gknd 8057 11 the the DT cord-010119-t1x9gknd 8057 12 notion notion NN cord-010119-t1x9gknd 8057 13 that that IN cord-010119-t1x9gknd 8057 14 normal normal JJ cord-010119-t1x9gknd 8057 15 colonization colonization NN cord-010119-t1x9gknd 8057 16 of of IN cord-010119-t1x9gknd 8057 17 the the DT cord-010119-t1x9gknd 8057 18 gut gut NN cord-010119-t1x9gknd 8057 19 is be VBZ cord-010119-t1x9gknd 8057 20 important important JJ cord-010119-t1x9gknd 8057 21 in in IN cord-010119-t1x9gknd 8057 22 the the DT cord-010119-t1x9gknd 8057 23 development development NN cord-010119-t1x9gknd 8057 24 of of IN cord-010119-t1x9gknd 8057 25 anti anti JJ cord-010119-t1x9gknd 8057 26 - - JJ cord-010119-t1x9gknd 8057 27 A a NN cord-010119-t1x9gknd 8057 28 and and CC cord-010119-t1x9gknd 8057 29 -B -b ADD cord-010119-t1x9gknd 8057 30 and and CC cord-010119-t1x9gknd 8057 31 suggests suggest VBZ cord-010119-t1x9gknd 8057 32 that that IN cord-010119-t1x9gknd 8057 33 microflora microflora NN cord-010119-t1x9gknd 8057 34 of of IN cord-010119-t1x9gknd 8057 35 the the DT cord-010119-t1x9gknd 8057 36 gut gut NN cord-010119-t1x9gknd 8057 37 in in IN cord-010119-t1x9gknd 8057 38 patients patient NNS cord-010119-t1x9gknd 8057 39 on on IN cord-010119-t1x9gknd 8057 40 prolonged prolong VBN cord-010119-t1x9gknd 8057 41 TPN TPN NNP cord-010119-t1x9gknd 8057 42 is be VBZ cord-010119-t1x9gknd 8057 43 different different JJ cord-010119-t1x9gknd 8057 44 leading lead VBG cord-010119-t1x9gknd 8057 45 to to IN cord-010119-t1x9gknd 8057 46 the the DT cord-010119-t1x9gknd 8057 47 delayed delay VBN cord-010119-t1x9gknd 8057 48 formation formation NN cord-010119-t1x9gknd 8057 49 of of IN cord-010119-t1x9gknd 8057 50 these these DT cord-010119-t1x9gknd 8057 51 antibodies antibody NNS cord-010119-t1x9gknd 8057 52 compared compare VBN cord-010119-t1x9gknd 8057 53 to to IN cord-010119-t1x9gknd 8057 54 individuals individual NNS cord-010119-t1x9gknd 8057 55 on on IN cord-010119-t1x9gknd 8057 56 normal normal JJ cord-010119-t1x9gknd 8057 57 enteral enteral JJ cord-010119-t1x9gknd 8057 58 diet diet NN cord-010119-t1x9gknd 8057 59 . . . cord-010119-t1x9gknd 8058 1 Difference difference NN cord-010119-t1x9gknd 8058 2 in in IN cord-010119-t1x9gknd 8058 3 strength strength NN cord-010119-t1x9gknd 8058 4 of of IN cord-010119-t1x9gknd 8059 1 anti anti JJ cord-010119-t1x9gknd 8059 2 - - JJ cord-010119-t1x9gknd 8059 3 A a JJ cord-010119-t1x9gknd 8059 4 and and CC cord-010119-t1x9gknd 8059 5 - - HYPH cord-010119-t1x9gknd 8059 6 B b NN cord-010119-t1x9gknd 8059 7 could could MD cord-010119-t1x9gknd 8059 8 be be VB cord-010119-t1x9gknd 8059 9 due due JJ cord-010119-t1x9gknd 8059 10 to to IN cord-010119-t1x9gknd 8059 11 stronger strong JJR cord-010119-t1x9gknd 8059 12 A a NN cord-010119-t1x9gknd 8059 13 than than IN cord-010119-t1x9gknd 8059 14 B b NN cord-010119-t1x9gknd 8059 15 antigen antigen NN cord-010119-t1x9gknd 8059 16 expression expression NN cord-010119-t1x9gknd 8059 17 on on IN cord-010119-t1x9gknd 8059 18 gut gut NN cord-010119-t1x9gknd 8059 19 bacteria bacteria NNS cord-010119-t1x9gknd 8059 20 . . . cord-010119-t1x9gknd 8060 1 Results/ Results/ . cord-010119-t1x9gknd 8061 1 Finding finding NN cord-010119-t1x9gknd 8061 2 : : : cord-010119-t1x9gknd 8062 1 A a DT cord-010119-t1x9gknd 8062 2 daratumumab daratumumab VBN cord-010119-t1x9gknd 8062 3 protocol protocol NN cord-010119-t1x9gknd 8062 4 was be VBD cord-010119-t1x9gknd 8062 5 established establish VBN cord-010119-t1x9gknd 8062 6 that that IN cord-010119-t1x9gknd 8062 7 incorporated incorporate VBN cord-010119-t1x9gknd 8062 8 use use NN cord-010119-t1x9gknd 8062 9 of of IN cord-010119-t1x9gknd 8062 10 the the DT cord-010119-t1x9gknd 8062 11 cord cord NN cord-010119-t1x9gknd 8062 12 panel panel NN cord-010119-t1x9gknd 8062 13 . . . cord-010119-t1x9gknd 8063 1 Multiple multiple JJ cord-010119-t1x9gknd 8063 2 myeloma myeloma NN cord-010119-t1x9gknd 8063 3 patients patient NNS cord-010119-t1x9gknd 8063 4 selected select VBN cord-010119-t1x9gknd 8063 5 as as IN cord-010119-t1x9gknd 8063 6 candidates candidate NNS cord-010119-t1x9gknd 8063 7 for for IN cord-010119-t1x9gknd 8063 8 daratumumab daratumumab JJ cord-010119-t1x9gknd 8063 9 treatment treatment NN cord-010119-t1x9gknd 8063 10 were be VBD cord-010119-t1x9gknd 8063 11 baseline baseline JJ cord-010119-t1x9gknd 8063 12 tested test VBN cord-010119-t1x9gknd 8063 13 for for IN cord-010119-t1x9gknd 8063 14 blood blood NN cord-010119-t1x9gknd 8063 15 type type NN cord-010119-t1x9gknd 8063 16 and and CC cord-010119-t1x9gknd 8063 17 antibody antibody NN cord-010119-t1x9gknd 8063 18 screen screen NN cord-010119-t1x9gknd 8063 19 , , , cord-010119-t1x9gknd 8063 20 DAT DAT NNP cord-010119-t1x9gknd 8063 21 and and CC cord-010119-t1x9gknd 8063 22 genotype genotype NN cord-010119-t1x9gknd 8063 23 . . . cord-010119-t1x9gknd 8064 1 After after IN cord-010119-t1x9gknd 8064 2 daratumumab daratumumab NNP cord-010119-t1x9gknd 8064 3 infusion infusion NN cord-010119-t1x9gknd 8064 4 , , , cord-010119-t1x9gknd 8064 5 a a DT cord-010119-t1x9gknd 8064 6 two two CD cord-010119-t1x9gknd 8064 7 unit unit NN cord-010119-t1x9gknd 8064 8 crossmatch crossmatch NN cord-010119-t1x9gknd 8064 9 was be VBD cord-010119-t1x9gknd 8064 10 order order NN cord-010119-t1x9gknd 8064 11 as as IN cord-010119-t1x9gknd 8064 12 a a DT cord-010119-t1x9gknd 8064 13 precaution precaution NN cord-010119-t1x9gknd 8064 14 in in IN cord-010119-t1x9gknd 8064 15 the the DT cord-010119-t1x9gknd 8064 16 event event NN cord-010119-t1x9gknd 8064 17 the the DT cord-010119-t1x9gknd 8064 18 patient patient NN cord-010119-t1x9gknd 8064 19 developed develop VBD cord-010119-t1x9gknd 8064 20 a a DT cord-010119-t1x9gknd 8064 21 reaction reaction NN cord-010119-t1x9gknd 8064 22 to to IN cord-010119-t1x9gknd 8064 23 the the DT cord-010119-t1x9gknd 8064 24 medication medication NN cord-010119-t1x9gknd 8064 25 . . . cord-010119-t1x9gknd 8065 1 Repeat repeat NN cord-010119-t1x9gknd 8065 2 of of IN cord-010119-t1x9gknd 8065 3 the the DT cord-010119-t1x9gknd 8065 4 antibody antibody NN cord-010119-t1x9gknd 8065 5 screen screen NN cord-010119-t1x9gknd 8065 6 demonstrated demonstrate VBD cord-010119-t1x9gknd 8065 7 panagglutination panagglutination NN cord-010119-t1x9gknd 8065 8 which which WDT cord-010119-t1x9gknd 8065 9 served serve VBD cord-010119-t1x9gknd 8065 10 as as IN cord-010119-t1x9gknd 8065 11 a a DT cord-010119-t1x9gknd 8065 12 positive positive JJ cord-010119-t1x9gknd 8065 13 control control NN cord-010119-t1x9gknd 8065 14 for for IN cord-010119-t1x9gknd 8065 15 the the DT cord-010119-t1x9gknd 8065 16 medication medication NN cord-010119-t1x9gknd 8065 17 . . . cord-010119-t1x9gknd 8066 1 The the DT cord-010119-t1x9gknd 8066 2 cord cord NN cord-010119-t1x9gknd 8066 3 panel panel NN cord-010119-t1x9gknd 8066 4 ruled rule VBD cord-010119-t1x9gknd 8066 5 out out RP cord-010119-t1x9gknd 8066 6 underlying underlie VBG cord-010119-t1x9gknd 8066 7 alloantibodies alloantibody NNS cord-010119-t1x9gknd 8066 8 . . . cord-010119-t1x9gknd 8067 1 Selected select VBN cord-010119-t1x9gknd 8067 2 red red JJ cord-010119-t1x9gknd 8067 3 cell cell NN cord-010119-t1x9gknd 8067 4 units unit NNS cord-010119-t1x9gknd 8067 5 were be VBD cord-010119-t1x9gknd 8067 6 crossmatched crossmatche VBN cord-010119-t1x9gknd 8067 7 at at IN cord-010119-t1x9gknd 8067 8 immediate immediate JJ cord-010119-t1x9gknd 8067 9 spin spin NN cord-010119-t1x9gknd 8067 10 phase phase NN cord-010119-t1x9gknd 8067 11 to to TO cord-010119-t1x9gknd 8067 12 avoid avoid VB cord-010119-t1x9gknd 8067 13 expected expect VBN cord-010119-t1x9gknd 8067 14 indirect indirect JJ cord-010119-t1x9gknd 8067 15 antiglobulin antiglobulin NN cord-010119-t1x9gknd 8067 16 reactivity reactivity NN cord-010119-t1x9gknd 8067 17 . . . cord-010119-t1x9gknd 8068 1 Conclusion conclusion NN cord-010119-t1x9gknd 8068 2 : : : cord-010119-t1x9gknd 8069 1 The the DT cord-010119-t1x9gknd 8069 2 cord cord NN cord-010119-t1x9gknd 8069 3 panel panel NN cord-010119-t1x9gknd 8069 4 was be VBD cord-010119-t1x9gknd 8069 5 used use VBN cord-010119-t1x9gknd 8069 6 28 28 CD cord-010119-t1x9gknd 8069 7 times time NNS cord-010119-t1x9gknd 8069 8 over over IN cord-010119-t1x9gknd 8069 9 a a DT cord-010119-t1x9gknd 8069 10 five five CD cord-010119-t1x9gknd 8069 11 month month NN cord-010119-t1x9gknd 8069 12 period period NN cord-010119-t1x9gknd 8069 13 to to TO cord-010119-t1x9gknd 8069 14 rule rule VB cord-010119-t1x9gknd 8069 15 out out RP cord-010119-t1x9gknd 8069 16 underlying underlie VBG cord-010119-t1x9gknd 8069 17 alloantibodies alloantibody NNS cord-010119-t1x9gknd 8069 18 . . . cord-010119-t1x9gknd 8070 1 Tests test NNS cord-010119-t1x9gknd 8070 2 for for IN cord-010119-t1x9gknd 8070 3 the the DT cord-010119-t1x9gknd 8070 4 daratumumab daratumumab NNP cord-010119-t1x9gknd 8070 5 protocol protocol NN cord-010119-t1x9gknd 8070 6 consisted consist VBD cord-010119-t1x9gknd 8070 7 of of IN cord-010119-t1x9gknd 8070 8 a a DT cord-010119-t1x9gknd 8070 9 routing route VBG cord-010119-t1x9gknd 8070 10 antibody antibody NN cord-010119-t1x9gknd 8070 11 screen screen NN cord-010119-t1x9gknd 8070 12 followed follow VBN cord-010119-t1x9gknd 8070 13 by by IN cord-010119-t1x9gknd 8070 14 a a DT cord-010119-t1x9gknd 8070 15 cord cord NN cord-010119-t1x9gknd 8070 16 panel panel NN cord-010119-t1x9gknd 8070 17 for for IN cord-010119-t1x9gknd 8070 18 resolution resolution NN cord-010119-t1x9gknd 8070 19 . . . cord-010119-t1x9gknd 8071 1 The the DT cord-010119-t1x9gknd 8071 2 daratumumab daratumumab VBN cord-010119-t1x9gknd 8071 3 protocol protocol NN cord-010119-t1x9gknd 8071 4 significantly significantly RB cord-010119-t1x9gknd 8071 5 reduced reduce VBD cord-010119-t1x9gknd 8071 6 testing testing NN cord-010119-t1x9gknd 8071 7 time time NN cord-010119-t1x9gknd 8071 8 and and CC cord-010119-t1x9gknd 8071 9 allowed allow VBN cord-010119-t1x9gknd 8071 10 for for IN cord-010119-t1x9gknd 8071 11 the the DT cord-010119-t1x9gknd 8071 12 provision provision NN cord-010119-t1x9gknd 8071 13 of of IN cord-010119-t1x9gknd 8071 14 compatible compatible JJ cord-010119-t1x9gknd 8071 15 blood blood NN cord-010119-t1x9gknd 8071 16 products product NNS cord-010119-t1x9gknd 8071 17 in in IN cord-010119-t1x9gknd 8071 18 an an DT cord-010119-t1x9gknd 8071 19 efficient efficient JJ cord-010119-t1x9gknd 8071 20 and and CC cord-010119-t1x9gknd 8071 21 cost cost VB cord-010119-t1x9gknd 8071 22 effective effective JJ cord-010119-t1x9gknd 8071 23 manner manner NN cord-010119-t1x9gknd 8071 24 . . . cord-010119-t1x9gknd 8072 1 Teresa Teresa NNP cord-010119-t1x9gknd 8072 2 Gorey Gorey NNP cord-010119-t1x9gknd 8072 3 * * NFP cord-010119-t1x9gknd 8072 4 1 1 CD cord-010119-t1x9gknd 8072 5 and and CC cord-010119-t1x9gknd 8072 6 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 8072 7 Hart Hart NNP cord-010119-t1x9gknd 8072 8 2 2 CD cord-010119-t1x9gknd 8072 9 . . . cord-010119-t1x9gknd 8072 10 1 1 CD cord-010119-t1x9gknd 8072 11 Brigham Brigham NNP cord-010119-t1x9gknd 8072 12 and and CC cord-010119-t1x9gknd 8072 13 Women Women NNP cord-010119-t1x9gknd 8072 14 's 's POS cord-010119-t1x9gknd 8072 15 Faulkner Faulkner NNP cord-010119-t1x9gknd 8072 16 Hospital Hospital NNP cord-010119-t1x9gknd 8072 17 , , , cord-010119-t1x9gknd 8072 18 2 2 CD cord-010119-t1x9gknd 8072 19 University University NNP cord-010119-t1x9gknd 8072 20 of of IN cord-010119-t1x9gknd 8072 21 Massachusetts Massachusetts NNP cord-010119-t1x9gknd 8072 22 - - HYPH cord-010119-t1x9gknd 8072 23 Dartmouth Dartmouth NNP cord-010119-t1x9gknd 8072 24 Background Background NNP cord-010119-t1x9gknd 8072 25 / / SYM cord-010119-t1x9gknd 8072 26 Case Case NNP cord-010119-t1x9gknd 8072 27 Studies Studies NNPS cord-010119-t1x9gknd 8072 28 : : : cord-010119-t1x9gknd 8073 1 The the DT cord-010119-t1x9gknd 8073 2 purpose purpose NN cord-010119-t1x9gknd 8073 3 of of IN cord-010119-t1x9gknd 8073 4 performing perform VBG cord-010119-t1x9gknd 8073 5 a a DT cord-010119-t1x9gknd 8073 6 pre pre JJ cord-010119-t1x9gknd 8073 7 - - JJ cord-010119-t1x9gknd 8073 8 transfusion transfusion JJ cord-010119-t1x9gknd 8073 9 antibody antibody NN cord-010119-t1x9gknd 8073 10 screen screen NN cord-010119-t1x9gknd 8073 11 is be VBZ cord-010119-t1x9gknd 8073 12 to to TO cord-010119-t1x9gknd 8073 13 detect detect VB cord-010119-t1x9gknd 8073 14 clinically clinically RB cord-010119-t1x9gknd 8073 15 significant significant JJ cord-010119-t1x9gknd 8073 16 unexpected unexpected JJ cord-010119-t1x9gknd 8073 17 antibodies antibody NNS cord-010119-t1x9gknd 8073 18 and and CC cord-010119-t1x9gknd 8073 19 to to TO cord-010119-t1x9gknd 8073 20 decrease decrease VB cord-010119-t1x9gknd 8073 21 the the DT cord-010119-t1x9gknd 8073 22 probability probability NN cord-010119-t1x9gknd 8073 23 of of IN cord-010119-t1x9gknd 8073 24 detecting detect VBG cord-010119-t1x9gknd 8073 25 clinically clinically RB cord-010119-t1x9gknd 8073 26 insignificant insignificant JJ cord-010119-t1x9gknd 8073 27 antibodies antibody NNS cord-010119-t1x9gknd 8073 28 . . . cord-010119-t1x9gknd 8074 1 Several several JJ cord-010119-t1x9gknd 8074 2 antibody antibody NN cord-010119-t1x9gknd 8074 3 detection detection NN cord-010119-t1x9gknd 8074 4 methods method NNS cord-010119-t1x9gknd 8074 5 ( ( -LRB- cord-010119-t1x9gknd 8074 6 Polyethylene polyethylene NN cord-010119-t1x9gknd 8074 7 glycol glycol NN cord-010119-t1x9gknd 8074 8 ( ( -LRB- cord-010119-t1x9gknd 8074 9 PEG PEG NNP cord-010119-t1x9gknd 8074 10 ) ) -RRB- cord-010119-t1x9gknd 8074 11 , , , cord-010119-t1x9gknd 8074 12 LISS LISS NNP cord-010119-t1x9gknd 8074 13 , , , cord-010119-t1x9gknd 8074 14 and and CC cord-010119-t1x9gknd 8074 15 albumin albumin NN cord-010119-t1x9gknd 8074 16 ) ) -RRB- cord-010119-t1x9gknd 8074 17 are be VBP cord-010119-t1x9gknd 8074 18 routinely routinely RB cord-010119-t1x9gknd 8074 19 used use VBN cord-010119-t1x9gknd 8074 20 in in IN cord-010119-t1x9gknd 8074 21 small small JJ cord-010119-t1x9gknd 8074 22 transfusion transfusion NN cord-010119-t1x9gknd 8074 23 services service NNS cord-010119-t1x9gknd 8074 24 . . . cord-010119-t1x9gknd 8075 1 The the DT cord-010119-t1x9gknd 8075 2 utility utility NN cord-010119-t1x9gknd 8075 3 of of IN cord-010119-t1x9gknd 8075 4 PEG PEG NNP cord-010119-t1x9gknd 8075 5 is be VBZ cord-010119-t1x9gknd 8075 6 to to TO cord-010119-t1x9gknd 8075 7 enhance enhance VB cord-010119-t1x9gknd 8075 8 the the DT cord-010119-t1x9gknd 8075 9 sensitivity sensitivity NN cord-010119-t1x9gknd 8075 10 of of IN cord-010119-t1x9gknd 8075 11 detecting detect VBG cord-010119-t1x9gknd 8075 12 clinically clinically RB cord-010119-t1x9gknd 8075 13 significant significant JJ cord-010119-t1x9gknd 8075 14 antibodies antibody NNS cord-010119-t1x9gknd 8075 15 by by IN cord-010119-t1x9gknd 8075 16 the the DT cord-010119-t1x9gknd 8075 17 indirect indirect JJ cord-010119-t1x9gknd 8075 18 antiglobulin antiglobulin NN cord-010119-t1x9gknd 8075 19 procedure procedure NN cord-010119-t1x9gknd 8075 20 . . . cord-010119-t1x9gknd 8076 1 The the DT cord-010119-t1x9gknd 8076 2 Code Code NNP cord-010119-t1x9gknd 8076 3 of of IN cord-010119-t1x9gknd 8076 4 Federal Federal NNP cord-010119-t1x9gknd 8076 5 Regulations Regulations NNPS cord-010119-t1x9gknd 8076 6 , , , cord-010119-t1x9gknd 8076 7 Title title NN cord-010119-t1x9gknd 8076 8 42 42 CD cord-010119-t1x9gknd 8076 9 , , , cord-010119-t1x9gknd 8076 10 CFR CFR NNP cord-010119-t1x9gknd 8076 11 part part NN cord-010119-t1x9gknd 8076 12 493.1271(a 493.1271(a CD cord-010119-t1x9gknd 8076 13 ) ) -RRB- cord-010119-t1x9gknd 8076 14 , , , cord-010119-t1x9gknd 8076 15 states state VBZ cord-010119-t1x9gknd 8076 16 the the DT cord-010119-t1x9gknd 8076 17 manufacturer manufacturer NN cord-010119-t1x9gknd 8076 18 's 's POS cord-010119-t1x9gknd 8076 19 instructions instruction NNS cord-010119-t1x9gknd 8076 20 are be VBP cord-010119-t1x9gknd 8076 21 followed follow VBN cord-010119-t1x9gknd 8076 22 when when WRB cord-010119-t1x9gknd 8076 23 testing test VBG cord-010119-t1x9gknd 8076 24 for for IN cord-010119-t1x9gknd 8076 25 unexpected unexpected JJ cord-010119-t1x9gknd 8076 26 antibodies antibody NNS cord-010119-t1x9gknd 8076 27 . . . cord-010119-t1x9gknd 8077 1 The the DT cord-010119-t1x9gknd 8077 2 package package NN cord-010119-t1x9gknd 8077 3 insert insert NN cord-010119-t1x9gknd 8077 4 for for IN cord-010119-t1x9gknd 8077 5 Gamma Gamma NNP cord-010119-t1x9gknd 8077 6 PeG peg NN cord-010119-t1x9gknd 8077 7 TM TM NNP cord-010119-t1x9gknd 8077 8 ( ( -LRB- cord-010119-t1x9gknd 8077 9 Immucor Immucor NNP cord-010119-t1x9gknd 8077 10 Inc. Inc. NNP cord-010119-t1x9gknd 8077 11 , , , cord-010119-t1x9gknd 8077 12 Norcross Norcross NNP cord-010119-t1x9gknd 8077 13 , , , cord-010119-t1x9gknd 8077 14 GA GA NNP cord-010119-t1x9gknd 8077 15 ) ) -RRB- cord-010119-t1x9gknd 8077 16 , , , cord-010119-t1x9gknd 8077 17 states state VBZ cord-010119-t1x9gknd 8077 18 that that IN cord-010119-t1x9gknd 8077 19 negative negative JJ cord-010119-t1x9gknd 8077 20 reactions reaction NNS cord-010119-t1x9gknd 8077 21 may may MD cord-010119-t1x9gknd 8077 22 be be VB cord-010119-t1x9gknd 8077 23 examined examine VBN cord-010119-t1x9gknd 8077 24 with with IN cord-010119-t1x9gknd 8077 25 an an DT cord-010119-t1x9gknd 8077 26 optical optical JJ cord-010119-t1x9gknd 8077 27 aid aid NN cord-010119-t1x9gknd 8077 28 . . . cord-010119-t1x9gknd 8078 1 Based base VBN cord-010119-t1x9gknd 8078 2 on on IN cord-010119-t1x9gknd 8078 3 these these DT cord-010119-t1x9gknd 8078 4 directions direction NNS cord-010119-t1x9gknd 8078 5 , , , cord-010119-t1x9gknd 8078 6 our -PRON- PRP$ cord-010119-t1x9gknd 8078 7 institutional institutional JJ cord-010119-t1x9gknd 8078 8 policy policy NN cord-010119-t1x9gknd 8078 9 is be VBZ cord-010119-t1x9gknd 8078 10 to to TO cord-010119-t1x9gknd 8078 11 confirm confirm VB cord-010119-t1x9gknd 8078 12 all all DT cord-010119-t1x9gknd 8078 13 negative negative JJ cord-010119-t1x9gknd 8078 14 reactions reaction NNS cord-010119-t1x9gknd 8078 15 using use VBG cord-010119-t1x9gknd 8078 16 the the DT cord-010119-t1x9gknd 8078 17 microscope microscope NN cord-010119-t1x9gknd 8078 18 . . . cord-010119-t1x9gknd 8079 1 Study Study NNP cord-010119-t1x9gknd 8079 2 Design Design NNP cord-010119-t1x9gknd 8079 3 / / SYM cord-010119-t1x9gknd 8079 4 Method method NN cord-010119-t1x9gknd 8079 5 : : : cord-010119-t1x9gknd 8080 1 A a DT cord-010119-t1x9gknd 8080 2 one one CD cord-010119-t1x9gknd 8080 3 - - HYPH cord-010119-t1x9gknd 8080 4 year year NN cord-010119-t1x9gknd 8080 5 retrospective retrospective JJ cord-010119-t1x9gknd 8080 6 document document NN cord-010119-t1x9gknd 8080 7 review review NN cord-010119-t1x9gknd 8080 8 was be VBD cord-010119-t1x9gknd 8080 9 performed perform VBN cord-010119-t1x9gknd 8080 10 on on IN cord-010119-t1x9gknd 8080 11 all all DT cord-010119-t1x9gknd 8080 12 patient patient JJ cord-010119-t1x9gknd 8080 13 samples sample NNS cord-010119-t1x9gknd 8080 14 in in IN cord-010119-t1x9gknd 8080 15 which which WDT cord-010119-t1x9gknd 8080 16 a a DT cord-010119-t1x9gknd 8080 17 positive positive JJ cord-010119-t1x9gknd 8080 18 antibody antibody NN cord-010119-t1x9gknd 8080 19 screen screen NN cord-010119-t1x9gknd 8080 20 ( ( -LRB- cord-010119-t1x9gknd 8080 21 ABSC ABSC NNP cord-010119-t1x9gknd 8080 22 ) ) -RRB- cord-010119-t1x9gknd 8080 23 triggered trigger VBD cord-010119-t1x9gknd 8080 24 the the DT cord-010119-t1x9gknd 8080 25 antibody antibody NN cord-010119-t1x9gknd 8080 26 identification identification NN cord-010119-t1x9gknd 8080 27 ( ( -LRB- cord-010119-t1x9gknd 8080 28 ABID ABID NNP cord-010119-t1x9gknd 8080 29 ) ) -RRB- cord-010119-t1x9gknd 8080 30 to to TO cord-010119-t1x9gknd 8080 31 be be VB cord-010119-t1x9gknd 8080 32 performed perform VBN cord-010119-t1x9gknd 8080 33 in in IN cord-010119-t1x9gknd 8080 34 2016 2016 CD cord-010119-t1x9gknd 8080 35 . . . cord-010119-t1x9gknd 8081 1 A a DT cord-010119-t1x9gknd 8081 2 total total NN cord-010119-t1x9gknd 8081 3 of of IN cord-010119-t1x9gknd 8081 4 232 232 CD cord-010119-t1x9gknd 8081 5 samples sample NNS cord-010119-t1x9gknd 8081 6 were be VBD cord-010119-t1x9gknd 8081 7 evaluated evaluate VBN cord-010119-t1x9gknd 8081 8 . . . cord-010119-t1x9gknd 8082 1 Each each DT cord-010119-t1x9gknd 8082 2 ABID ABID NNP cord-010119-t1x9gknd 8082 3 was be VBD cord-010119-t1x9gknd 8082 4 subcategorized subcategorize VBN cord-010119-t1x9gknd 8082 5 ; ; : cord-010119-t1x9gknd 8082 6 ( ( -LRB- cord-010119-t1x9gknd 8082 7 1 1 LS cord-010119-t1x9gknd 8082 8 ) ) -RRB- cord-010119-t1x9gknd 8082 9 as as IN cord-010119-t1x9gknd 8082 10 being be VBG cord-010119-t1x9gknd 8082 11 a a DT cord-010119-t1x9gknd 8082 12 new new JJ cord-010119-t1x9gknd 8082 13 antibody antibody NN cord-010119-t1x9gknd 8082 14 for for IN cord-010119-t1x9gknd 8082 15 our -PRON- PRP$ cord-010119-t1x9gknd 8082 16 facility facility NN cord-010119-t1x9gknd 8082 17 or or CC cord-010119-t1x9gknd 8082 18 in in IN cord-010119-t1x9gknd 8082 19 the the DT cord-010119-t1x9gknd 8082 20 patient patient NN cord-010119-t1x9gknd 8082 21 's 's POS cord-010119-t1x9gknd 8082 22 shared share VBN cord-010119-t1x9gknd 8082 23 electronic electronic JJ cord-010119-t1x9gknd 8082 24 health health NN cord-010119-t1x9gknd 8082 25 record record NN cord-010119-t1x9gknd 8082 26 within within IN cord-010119-t1x9gknd 8082 27 the the DT cord-010119-t1x9gknd 8082 28 PartnersV PartnersV NNP cord-010119-t1x9gknd 8082 29 R R NNP cord-010119-t1x9gknd 8082 30 Healthcare Healthcare NNP cord-010119-t1x9gknd 8082 31 system system NN cord-010119-t1x9gknd 8082 32 and and CC cord-010119-t1x9gknd 8082 33 ( ( -LRB- cord-010119-t1x9gknd 8082 34 2 2 LS cord-010119-t1x9gknd 8082 35 ) ) -RRB- cord-010119-t1x9gknd 8082 36 whether whether IN cord-010119-t1x9gknd 8082 37 a a DT cord-010119-t1x9gknd 8082 38 microscopic microscopic JJ cord-010119-t1x9gknd 8082 39 ABSC ABSC NNP cord-010119-t1x9gknd 8082 40 result result NN cord-010119-t1x9gknd 8082 41 triggered trigger VBD cord-010119-t1x9gknd 8082 42 the the DT cord-010119-t1x9gknd 8082 43 ABID ABID NNP cord-010119-t1x9gknd 8082 44 . . . cord-010119-t1x9gknd 8083 1 Also also RB cord-010119-t1x9gknd 8083 2 , , , cord-010119-t1x9gknd 8083 3 patients patient NNS cord-010119-t1x9gknd 8083 4 with with IN cord-010119-t1x9gknd 8083 5 known know VBN cord-010119-t1x9gknd 8083 6 antibodies antibody NNS cord-010119-t1x9gknd 8083 7 were be VBD cord-010119-t1x9gknd 8083 8 grouped group VBN cord-010119-t1x9gknd 8083 9 according accord VBG cord-010119-t1x9gknd 8083 10 to to IN cord-010119-t1x9gknd 8083 11 a a DT cord-010119-t1x9gknd 8083 12 microscopic microscopic JJ cord-010119-t1x9gknd 8083 13 ABSC ABSC NNP cord-010119-t1x9gknd 8083 14 result result NN cord-010119-t1x9gknd 8083 15 . . . cord-010119-t1x9gknd 8084 1 A a DT cord-010119-t1x9gknd 8084 2 comparison comparison NN cord-010119-t1x9gknd 8084 3 of of IN cord-010119-t1x9gknd 8084 4 the the DT cord-010119-t1x9gknd 8084 5 new new JJ cord-010119-t1x9gknd 8084 6 patients patient NNS cord-010119-t1x9gknd 8084 7 and and CC cord-010119-t1x9gknd 8084 8 the the DT cord-010119-t1x9gknd 8084 9 previously previously RB cord-010119-t1x9gknd 8084 10 known know VBN cord-010119-t1x9gknd 8084 11 antibody antibody NN cord-010119-t1x9gknd 8084 12 patients patient NNS cord-010119-t1x9gknd 8084 13 with with IN cord-010119-t1x9gknd 8084 14 microscopic microscopic JJ cord-010119-t1x9gknd 8084 15 results result NNS cord-010119-t1x9gknd 8084 16 were be VBD cord-010119-t1x9gknd 8084 17 reviewed review VBN cord-010119-t1x9gknd 8084 18 to to TO cord-010119-t1x9gknd 8084 19 determine determine VB cord-010119-t1x9gknd 8084 20 if if IN cord-010119-t1x9gknd 8084 21 the the DT cord-010119-t1x9gknd 8084 22 antibodies antibody NNS cord-010119-t1x9gknd 8084 23 were be VBD cord-010119-t1x9gknd 8084 24 clinically clinically RB cord-010119-t1x9gknd 8084 25 significant significant JJ cord-010119-t1x9gknd 8084 26 . . . cord-010119-t1x9gknd 8085 1 Results/ Results/ . cord-010119-t1x9gknd 8086 1 Finding finding NN cord-010119-t1x9gknd 8086 2 : : : cord-010119-t1x9gknd 8086 3 A a DT cord-010119-t1x9gknd 8086 4 total total NN cord-010119-t1x9gknd 8086 5 of of IN cord-010119-t1x9gknd 8086 6 83 83 CD cord-010119-t1x9gknd 8086 7 ABIDs ABIDs NNPS cord-010119-t1x9gknd 8086 8 were be VBD cord-010119-t1x9gknd 8086 9 performed perform VBN cord-010119-t1x9gknd 8086 10 on on IN cord-010119-t1x9gknd 8086 11 new new JJ cord-010119-t1x9gknd 8086 12 patient patient NN cord-010119-t1x9gknd 8086 13 samples sample NNS cord-010119-t1x9gknd 8086 14 . . . cord-010119-t1x9gknd 8087 1 Of of IN cord-010119-t1x9gknd 8087 2 the the DT cord-010119-t1x9gknd 8087 3 new new JJ cord-010119-t1x9gknd 8087 4 ABID ABID NNP cord-010119-t1x9gknd 8087 5 samples sample NNS cord-010119-t1x9gknd 8087 6 , , , cord-010119-t1x9gknd 8087 7 29 29 CD cord-010119-t1x9gknd 8087 8 ( ( -LRB- cord-010119-t1x9gknd 8087 9 35 35 CD cord-010119-t1x9gknd 8087 10 % % NN cord-010119-t1x9gknd 8087 11 ) ) -RRB- cord-010119-t1x9gknd 8087 12 had have VBD cord-010119-t1x9gknd 8087 13 microscopic microscopic JJ cord-010119-t1x9gknd 8087 14 ABSC ABSC NNP cord-010119-t1x9gknd 8087 15 results result NNS cord-010119-t1x9gknd 8087 16 . . . cord-010119-t1x9gknd 8088 1 For for IN cord-010119-t1x9gknd 8088 2 the the DT cord-010119-t1x9gknd 8088 3 previously previously RB cord-010119-t1x9gknd 8088 4 known know VBN cord-010119-t1x9gknd 8088 5 antibody antibody NN cord-010119-t1x9gknd 8088 6 patients patient NNS cord-010119-t1x9gknd 8088 7 , , , cord-010119-t1x9gknd 8088 8 there there EX cord-010119-t1x9gknd 8088 9 were be VBD cord-010119-t1x9gknd 8088 10 35 35 CD cord-010119-t1x9gknd 8088 11 which which WDT cord-010119-t1x9gknd 8088 12 accounted account VBD cord-010119-t1x9gknd 8088 13 for for IN cord-010119-t1x9gknd 8088 14 15 15 CD cord-010119-t1x9gknd 8088 15 % % NN cord-010119-t1x9gknd 8088 16 of of IN cord-010119-t1x9gknd 8088 17 the the DT cord-010119-t1x9gknd 8088 18 total total JJ cord-010119-t1x9gknd 8088 19 ABIDs ABIDs NNP cord-010119-t1x9gknd 8088 20 performed perform VBD cord-010119-t1x9gknd 8088 21 . . . cord-010119-t1x9gknd 8089 1 When when WRB cord-010119-t1x9gknd 8089 2 reviewing review VBG cord-010119-t1x9gknd 8089 3 the the DT cord-010119-t1x9gknd 8089 4 total total JJ cord-010119-t1x9gknd 8089 5 ABID ABID NNP cord-010119-t1x9gknd 8089 6 workups workup NNS cord-010119-t1x9gknd 8089 7 , , , cord-010119-t1x9gknd 8089 8 a a DT cord-010119-t1x9gknd 8089 9 total total NN cord-010119-t1x9gknd 8089 10 of of IN cord-010119-t1x9gknd 8089 11 64 64 CD cord-010119-t1x9gknd 8089 12 ( ( -LRB- cord-010119-t1x9gknd 8089 13 28 28 CD cord-010119-t1x9gknd 8089 14 % % NN cord-010119-t1x9gknd 8089 15 ) ) -RRB- cord-010119-t1x9gknd 8089 16 of of IN cord-010119-t1x9gknd 8089 17 the the DT cord-010119-t1x9gknd 8089 18 ABSCs absc NNS cord-010119-t1x9gknd 8089 19 had have VBD cord-010119-t1x9gknd 8089 20 microscopic microscopic JJ cord-010119-t1x9gknd 8089 21 results result NNS cord-010119-t1x9gknd 8089 22 which which WDT cord-010119-t1x9gknd 8089 23 resulted result VBD cord-010119-t1x9gknd 8089 24 in in IN cord-010119-t1x9gknd 8089 25 an an DT cord-010119-t1x9gknd 8089 26 ABID ABID NNP cord-010119-t1x9gknd 8089 27 being be VBG cord-010119-t1x9gknd 8089 28 performed perform VBN cord-010119-t1x9gknd 8089 29 . . . cord-010119-t1x9gknd 8090 1 The the DT cord-010119-t1x9gknd 8090 2 antibodies antibody NNS cord-010119-t1x9gknd 8090 3 identified identify VBN cord-010119-t1x9gknd 8090 4 in in IN cord-010119-t1x9gknd 8090 5 the the DT cord-010119-t1x9gknd 8090 6 29 29 CD cord-010119-t1x9gknd 8090 7 new new JJ cord-010119-t1x9gknd 8090 8 antibody antibody NN cord-010119-t1x9gknd 8090 9 samples sample NNS cord-010119-t1x9gknd 8090 10 were be VBD cord-010119-t1x9gknd 8090 11 : : : cord-010119-t1x9gknd 8091 1 Conclusion conclusion NN cord-010119-t1x9gknd 8091 2 : : : cord-010119-t1x9gknd 8091 3 A a DT cord-010119-t1x9gknd 8091 4 total total NN cord-010119-t1x9gknd 8091 5 of of IN cord-010119-t1x9gknd 8091 6 86 86 CD cord-010119-t1x9gknd 8091 7 % % NN cord-010119-t1x9gknd 8091 8 of of IN cord-010119-t1x9gknd 8091 9 the the DT cord-010119-t1x9gknd 8091 10 new new JJ cord-010119-t1x9gknd 8091 11 antibodies antibody NNS cord-010119-t1x9gknd 8091 12 identified identify VBN cord-010119-t1x9gknd 8091 13 based base VBN cord-010119-t1x9gknd 8091 14 on on IN cord-010119-t1x9gknd 8091 15 a a DT cord-010119-t1x9gknd 8091 16 microscopic microscopic JJ cord-010119-t1x9gknd 8091 17 ABSC ABSC NNS cord-010119-t1x9gknd 8091 18 were be VBD cord-010119-t1x9gknd 8091 19 clinically clinically RB cord-010119-t1x9gknd 8091 20 insignificant insignificant JJ cord-010119-t1x9gknd 8091 21 . . . cord-010119-t1x9gknd 8092 1 The the DT cord-010119-t1x9gknd 8092 2 manufacturer manufacturer NN cord-010119-t1x9gknd 8092 3 's 's POS cord-010119-t1x9gknd 8092 4 directions direction NNS cord-010119-t1x9gknd 8092 5 were be VBD cord-010119-t1x9gknd 8092 6 followed follow VBN cord-010119-t1x9gknd 8092 7 but but CC cord-010119-t1x9gknd 8092 8 they -PRON- PRP cord-010119-t1x9gknd 8092 9 do do VBP cord-010119-t1x9gknd 8092 10 not not RB cord-010119-t1x9gknd 8092 11 state state VB cord-010119-t1x9gknd 8092 12 that that IN cord-010119-t1x9gknd 8092 13 an an DT cord-010119-t1x9gknd 8092 14 optical optical JJ cord-010119-t1x9gknd 8092 15 aid aid NN cord-010119-t1x9gknd 8092 16 is be VBZ cord-010119-t1x9gknd 8092 17 required require VBN cord-010119-t1x9gknd 8092 18 to to TO cord-010119-t1x9gknd 8092 19 confirm confirm VB cord-010119-t1x9gknd 8092 20 all all DT cord-010119-t1x9gknd 8092 21 negative negative JJ cord-010119-t1x9gknd 8092 22 results result NNS cord-010119-t1x9gknd 8092 23 . . . cord-010119-t1x9gknd 8093 1 Due due IN cord-010119-t1x9gknd 8093 2 to to IN cord-010119-t1x9gknd 8093 3 the the DT cord-010119-t1x9gknd 8093 4 results result NNS cord-010119-t1x9gknd 8093 5 of of IN cord-010119-t1x9gknd 8093 6 this this DT cord-010119-t1x9gknd 8093 7 study study NN cord-010119-t1x9gknd 8093 8 , , , cord-010119-t1x9gknd 8093 9 a a DT cord-010119-t1x9gknd 8093 10 decision decision NN cord-010119-t1x9gknd 8093 11 will will MD cord-010119-t1x9gknd 8093 12 be be VB cord-010119-t1x9gknd 8093 13 made make VBN cord-010119-t1x9gknd 8093 14 to to IN cord-010119-t1x9gknd 8093 15 : : : cord-010119-t1x9gknd 8093 16 ( ( -LRB- cord-010119-t1x9gknd 8093 17 1 1 LS cord-010119-t1x9gknd 8093 18 ) ) -RRB- cord-010119-t1x9gknd 8093 19 discontinue discontinue VB cord-010119-t1x9gknd 8093 20 the the DT cord-010119-t1x9gknd 8093 21 use use NN cord-010119-t1x9gknd 8093 22 of of IN cord-010119-t1x9gknd 8093 23 the the DT cord-010119-t1x9gknd 8093 24 microscope microscope NN cord-010119-t1x9gknd 8093 25 , , , cord-010119-t1x9gknd 8093 26 ( ( -LRB- cord-010119-t1x9gknd 8093 27 2 2 LS cord-010119-t1x9gknd 8093 28 ) ) -RRB- cord-010119-t1x9gknd 8093 29 switch switch VB cord-010119-t1x9gknd 8093 30 to to IN cord-010119-t1x9gknd 8093 31 a a DT cord-010119-t1x9gknd 8093 32 PEG PEG NNP cord-010119-t1x9gknd 8093 33 manufacturer manufacturer NN cord-010119-t1x9gknd 8093 34 whose whose WP$ cord-010119-t1x9gknd 8093 35 directions direction NNS cord-010119-t1x9gknd 8093 36 indicate indicate VBP cord-010119-t1x9gknd 8093 37 to to TO cord-010119-t1x9gknd 8093 38 observe observe VB cord-010119-t1x9gknd 8093 39 macroscopically macroscopically RB cord-010119-t1x9gknd 8093 40 for for IN cord-010119-t1x9gknd 8093 41 agglutination agglutination NN cord-010119-t1x9gknd 8093 42 , , , cord-010119-t1x9gknd 8093 43 or or CC cord-010119-t1x9gknd 8093 44 ( ( -LRB- cord-010119-t1x9gknd 8093 45 3 3 LS cord-010119-t1x9gknd 8093 46 ) ) -RRB- cord-010119-t1x9gknd 8093 47 define define VB cord-010119-t1x9gknd 8093 48 the the DT cord-010119-t1x9gknd 8093 49 use use NN cord-010119-t1x9gknd 8093 50 of of IN cord-010119-t1x9gknd 8093 51 the the DT cord-010119-t1x9gknd 8093 52 agglutination agglutination NN cord-010119-t1x9gknd 8093 53 viewer viewer NN cord-010119-t1x9gknd 8093 54 as as IN cord-010119-t1x9gknd 8093 55 the the DT cord-010119-t1x9gknd 8093 56 optical optical JJ cord-010119-t1x9gknd 8093 57 aid aid NN cord-010119-t1x9gknd 8093 58 . . . cord-010119-t1x9gknd 8094 1 Decreasing decrease VBG cord-010119-t1x9gknd 8094 2 the the DT cord-010119-t1x9gknd 8094 3 number number NN cord-010119-t1x9gknd 8094 4 of of IN cord-010119-t1x9gknd 8094 5 ABIDs ABIDs NNPS cord-010119-t1x9gknd 8094 6 will will MD cord-010119-t1x9gknd 8094 7 save save VB cord-010119-t1x9gknd 8094 8 time time NN cord-010119-t1x9gknd 8094 9 and and CC cord-010119-t1x9gknd 8094 10 money money NN cord-010119-t1x9gknd 8094 11 while while IN cord-010119-t1x9gknd 8094 12 providing provide VBG cord-010119-t1x9gknd 8094 13 potential potential JJ cord-010119-t1x9gknd 8094 14 RBCs rbc NNS cord-010119-t1x9gknd 8094 15 for for IN cord-010119-t1x9gknd 8094 16 transfusion transfusion NN cord-010119-t1x9gknd 8094 17 in in IN cord-010119-t1x9gknd 8094 18 a a DT cord-010119-t1x9gknd 8094 19 timely timely JJ cord-010119-t1x9gknd 8094 20 and and CC cord-010119-t1x9gknd 8094 21 efficient efficient JJ cord-010119-t1x9gknd 8094 22 manner manner NN cord-010119-t1x9gknd 8094 23 . . . cord-010119-t1x9gknd 8095 1 Anton Anton NNP cord-010119-t1x9gknd 8095 2 " " '' cord-010119-t1x9gknd 8095 3 ) ) -RRB- cord-010119-t1x9gknd 8095 4 has have VBZ cord-010119-t1x9gknd 8095 5 a a DT cord-010119-t1x9gknd 8095 6 prevalence prevalence NN cord-010119-t1x9gknd 8095 7 greater great JJR cord-010119-t1x9gknd 8095 8 than than IN cord-010119-t1x9gknd 8095 9 99 99 CD cord-010119-t1x9gknd 8095 10 % % NN cord-010119-t1x9gknd 8095 11 in in IN cord-010119-t1x9gknd 8095 12 all all DT cord-010119-t1x9gknd 8095 13 populations population NNS cord-010119-t1x9gknd 8095 14 . . . cord-010119-t1x9gknd 8096 1 Hereditary hereditary JJ cord-010119-t1x9gknd 8096 2 absence absence NN cord-010119-t1x9gknd 8096 3 of of IN cord-010119-t1x9gknd 8096 4 AnWj AnWj NNP cord-010119-t1x9gknd 8096 5 has have VBZ cord-010119-t1x9gknd 8096 6 only only RB cord-010119-t1x9gknd 8096 7 been be VBN cord-010119-t1x9gknd 8096 8 described describe VBN cord-010119-t1x9gknd 8096 9 once once RB cord-010119-t1x9gknd 8096 10 ( ( -LRB- cord-010119-t1x9gknd 8096 11 in in IN cord-010119-t1x9gknd 8096 12 a a DT cord-010119-t1x9gknd 8096 13 single single JJ cord-010119-t1x9gknd 8096 14 family family NN cord-010119-t1x9gknd 8096 15 ) ) -RRB- cord-010119-t1x9gknd 8096 16 . . . cord-010119-t1x9gknd 8097 1 However however RB cord-010119-t1x9gknd 8097 2 , , , cord-010119-t1x9gknd 8097 3 red red JJ cord-010119-t1x9gknd 8097 4 cell cell NN cord-010119-t1x9gknd 8097 5 expression expression NN cord-010119-t1x9gknd 8097 6 of of IN cord-010119-t1x9gknd 8097 7 AnWj AnWj NNP cord-010119-t1x9gknd 8097 8 may may MD cord-010119-t1x9gknd 8097 9 be be VB cord-010119-t1x9gknd 8097 10 markedly markedly RB cord-010119-t1x9gknd 8097 11 decreased decrease VBN cord-010119-t1x9gknd 8097 12 to to IN cord-010119-t1x9gknd 8097 13 near near IN cord-010119-t1x9gknd 8097 14 undetectable undetectable JJ cord-010119-t1x9gknd 8097 15 levels level NNS cord-010119-t1x9gknd 8097 16 in in IN cord-010119-t1x9gknd 8097 17 blood blood NN cord-010119-t1x9gknd 8097 18 donors donor NNS cord-010119-t1x9gknd 8097 19 of of IN cord-010119-t1x9gknd 8097 20 the the DT cord-010119-t1x9gknd 8097 21 In(Lu In(Lu NNP cord-010119-t1x9gknd 8097 22 ) ) -RRB- cord-010119-t1x9gknd 8097 23 ( ( -LRB- cord-010119-t1x9gknd 8097 24 or or CC cord-010119-t1x9gknd 8098 1 " " `` cord-010119-t1x9gknd 8098 2 Dominant Dominant NNP cord-010119-t1x9gknd 8098 3 Lutheran Lutheran NNP cord-010119-t1x9gknd 8098 4 Inhibitor Inhibitor NNP cord-010119-t1x9gknd 8098 5 " " '' cord-010119-t1x9gknd 8098 6 ) ) -RRB- cord-010119-t1x9gknd 8098 7 phenotype phenotype NN cord-010119-t1x9gknd 8098 8 . . . cord-010119-t1x9gknd 8099 1 Similarly similarly RB cord-010119-t1x9gknd 8099 2 , , , cord-010119-t1x9gknd 8099 3 anti anti JJ cord-010119-t1x9gknd 8099 4 - - JJ cord-010119-t1x9gknd 8099 5 AnWj anwj JJ cord-010119-t1x9gknd 8099 6 antibody antibody NN cord-010119-t1x9gknd 8099 7 formation formation NN cord-010119-t1x9gknd 8099 8 is be VBZ cord-010119-t1x9gknd 8099 9 rare rare JJ cord-010119-t1x9gknd 8099 10 , , , cord-010119-t1x9gknd 8099 11 with with IN cord-010119-t1x9gknd 8099 12 only only RB cord-010119-t1x9gknd 8099 13 10 10 CD cord-010119-t1x9gknd 8099 14 cases case NNS cord-010119-t1x9gknd 8099 15 reported report VBN cord-010119-t1x9gknd 8099 16 in in IN cord-010119-t1x9gknd 8099 17 the the DT cord-010119-t1x9gknd 8099 18 literature literature NN cord-010119-t1x9gknd 8099 19 . . . cord-010119-t1x9gknd 8100 1 The the DT cord-010119-t1x9gknd 8100 2 antibody antibody NN cord-010119-t1x9gknd 8100 3 developed develop VBD cord-010119-t1x9gknd 8100 4 in in IN cord-010119-t1x9gknd 8100 5 the the DT cord-010119-t1x9gknd 8100 6 context context NN cord-010119-t1x9gknd 8100 7 of of IN cord-010119-t1x9gknd 8100 8 hereditary hereditary JJ cord-010119-t1x9gknd 8100 9 absence absence NN cord-010119-t1x9gknd 8100 10 of of IN cord-010119-t1x9gknd 8100 11 AnWj anwj NN cord-010119-t1x9gknd 8100 12 ( ( -LRB- cord-010119-t1x9gknd 8100 13 i.e. i.e. FW cord-010119-t1x9gknd 8100 14 , , , cord-010119-t1x9gknd 8100 15 a a DT cord-010119-t1x9gknd 8100 16 true true JJ cord-010119-t1x9gknd 8100 17 alloantibody alloantibody NN cord-010119-t1x9gknd 8100 18 ) ) -RRB- cord-010119-t1x9gknd 8100 19 in in IN cord-010119-t1x9gknd 8100 20 only only RB cord-010119-t1x9gknd 8100 21 one one CD cord-010119-t1x9gknd 8100 22 of of IN cord-010119-t1x9gknd 8100 23 the the DT cord-010119-t1x9gknd 8100 24 cases case NNS cord-010119-t1x9gknd 8100 25 . . . cord-010119-t1x9gknd 8101 1 In in IN cord-010119-t1x9gknd 8101 2 the the DT cord-010119-t1x9gknd 8101 3 other other JJ cord-010119-t1x9gknd 8101 4 nine nine CD cord-010119-t1x9gknd 8101 5 cases case NNS cord-010119-t1x9gknd 8101 6 , , , cord-010119-t1x9gknd 8101 7 the the DT cord-010119-t1x9gknd 8101 8 antibody antibody NN cord-010119-t1x9gknd 8101 9 occurred occur VBD cord-010119-t1x9gknd 8101 10 in in IN cord-010119-t1x9gknd 8101 11 the the DT cord-010119-t1x9gknd 8101 12 context context NN cord-010119-t1x9gknd 8101 13 of of IN cord-010119-t1x9gknd 8101 14 autoimmune autoimmune JJ cord-010119-t1x9gknd 8101 15 or or CC cord-010119-t1x9gknd 8101 16 lymphoproliferative lymphoproliferative JJ cord-010119-t1x9gknd 8101 17 disease disease NN cord-010119-t1x9gknd 8101 18 , , , cord-010119-t1x9gknd 8101 19 where where WRB cord-010119-t1x9gknd 8101 20 , , , cord-010119-t1x9gknd 8101 21 in in IN cord-010119-t1x9gknd 8101 22 this this DT cord-010119-t1x9gknd 8101 23 context context NN cord-010119-t1x9gknd 8101 24 , , , cord-010119-t1x9gknd 8101 25 it -PRON- PRP cord-010119-t1x9gknd 8101 26 is be VBZ cord-010119-t1x9gknd 8101 27 believed believe VBN cord-010119-t1x9gknd 8101 28 to to TO cord-010119-t1x9gknd 8101 29 have have VB cord-010119-t1x9gknd 8101 30 developed develop VBN cord-010119-t1x9gknd 8101 31 secondary secondary JJ cord-010119-t1x9gknd 8101 32 to to IN cord-010119-t1x9gknd 8101 33 transient transient JJ cord-010119-t1x9gknd 8101 34 AnWj AnWj NNP cord-010119-t1x9gknd 8101 35 antigen antigen NN cord-010119-t1x9gknd 8101 36 suppression suppression NN cord-010119-t1x9gknd 8101 37 . . . cord-010119-t1x9gknd 8102 1 Most Most JJS cord-010119-t1x9gknd 8102 2 of of IN cord-010119-t1x9gknd 8102 3 the the DT cord-010119-t1x9gknd 8102 4 reported report VBN cord-010119-t1x9gknd 8102 5 cases case NNS cord-010119-t1x9gknd 8102 6 lacked lack VBD cord-010119-t1x9gknd 8102 7 clinical clinical JJ cord-010119-t1x9gknd 8102 8 or or CC cord-010119-t1x9gknd 8102 9 laboratory laboratory JJ cord-010119-t1x9gknd 8102 10 evidence evidence NN cord-010119-t1x9gknd 8102 11 of of IN cord-010119-t1x9gknd 8102 12 hemolysis hemolysis NN cord-010119-t1x9gknd 8102 13 . . . cord-010119-t1x9gknd 8103 1 However however RB cord-010119-t1x9gknd 8103 2 , , , cord-010119-t1x9gknd 8103 3 in in IN cord-010119-t1x9gknd 8103 4 the the DT cord-010119-t1x9gknd 8103 5 most most RBS cord-010119-t1x9gknd 8103 6 recently recently RB cord-010119-t1x9gknd 8103 7 reported report VBN cord-010119-t1x9gknd 8103 8 case case NN cord-010119-t1x9gknd 8103 9 , , , cord-010119-t1x9gknd 8103 10 involving involve VBG cord-010119-t1x9gknd 8103 11 a a DT cord-010119-t1x9gknd 8103 12 56-yearold 56-yearold CD cord-010119-t1x9gknd 8103 13 woman woman NN cord-010119-t1x9gknd 8103 14 with with IN cord-010119-t1x9gknd 8103 15 aplastic aplastic JJ cord-010119-t1x9gknd 8103 16 anemia anemia NN cord-010119-t1x9gknd 8103 17 , , , cord-010119-t1x9gknd 8103 18 the the DT cord-010119-t1x9gknd 8103 19 antibody antibody NN cord-010119-t1x9gknd 8103 20 was be VBD cord-010119-t1x9gknd 8103 21 associated associate VBN cord-010119-t1x9gknd 8103 22 with with IN cord-010119-t1x9gknd 8103 23 acute acute JJ cord-010119-t1x9gknd 8103 24 hemolytic hemolytic JJ cord-010119-t1x9gknd 8103 25 reactions reaction NNS cord-010119-t1x9gknd 8103 26 after after IN cord-010119-t1x9gknd 8103 27 RBC RBC NNP cord-010119-t1x9gknd 8103 28 transfusions transfusion NNS cord-010119-t1x9gknd 8103 29 , , , cord-010119-t1x9gknd 8103 30 necessitating necessitate VBG cord-010119-t1x9gknd 8103 31 transfusion transfusion NN cord-010119-t1x9gknd 8103 32 support support NN cord-010119-t1x9gknd 8103 33 with with IN cord-010119-t1x9gknd 8103 34 AnWj anwj NN cord-010119-t1x9gknd 8103 35 - - HYPH cord-010119-t1x9gknd 8103 36 negative negative JJ cord-010119-t1x9gknd 8103 37 and and CC cord-010119-t1x9gknd 8103 38 In(Lu In(Lu NNP cord-010119-t1x9gknd 8103 39 ) ) -RRB- cord-010119-t1x9gknd 8103 40 RBCs rbc NNS cord-010119-t1x9gknd 8103 41 . . . cord-010119-t1x9gknd 8104 1 The the DT cord-010119-t1x9gknd 8104 2 case case NN cord-010119-t1x9gknd 8104 3 was be VBD cord-010119-t1x9gknd 8104 4 also also RB cord-010119-t1x9gknd 8104 5 unique unique JJ cord-010119-t1x9gknd 8104 6 in in IN cord-010119-t1x9gknd 8104 7 that that IN cord-010119-t1x9gknd 8104 8 the the DT cord-010119-t1x9gknd 8104 9 anti anti JJ cord-010119-t1x9gknd 8104 10 - - NNP cord-010119-t1x9gknd 8104 11 AnWj AnWj NNP cord-010119-t1x9gknd 8104 12 resulted result VBD cord-010119-t1x9gknd 8104 13 in in IN cord-010119-t1x9gknd 8104 14 a a DT cord-010119-t1x9gknd 8104 15 direct direct JJ cord-010119-t1x9gknd 8104 16 antiglobulin antiglobulin NN cord-010119-t1x9gknd 8104 17 test test NN cord-010119-t1x9gknd 8104 18 ( ( -LRB- cord-010119-t1x9gknd 8104 19 DAT DAT NNP cord-010119-t1x9gknd 8104 20 ) ) -RRB- cord-010119-t1x9gknd 8104 21 that that WDT cord-010119-t1x9gknd 8104 22 was be VBD cord-010119-t1x9gknd 8104 23 positive positive JJ cord-010119-t1x9gknd 8104 24 for for IN cord-010119-t1x9gknd 8104 25 complement complement NN cord-010119-t1x9gknd 8104 26 only only RB cord-010119-t1x9gknd 8104 27 , , , cord-010119-t1x9gknd 8104 28 rather rather RB cord-010119-t1x9gknd 8104 29 than than IN cord-010119-t1x9gknd 8104 30 IgG IgG NNP cord-010119-t1x9gknd 8104 31 like like IN cord-010119-t1x9gknd 8104 32 all all DT cord-010119-t1x9gknd 8104 33 previous previous JJ cord-010119-t1x9gknd 8104 34 cases case NNS cord-010119-t1x9gknd 8104 35 in in IN cord-010119-t1x9gknd 8104 36 which which WDT cord-010119-t1x9gknd 8104 37 the the DT cord-010119-t1x9gknd 8104 38 DAT DAT NNP cord-010119-t1x9gknd 8104 39 was be VBD cord-010119-t1x9gknd 8104 40 performed perform VBN cord-010119-t1x9gknd 8104 41 and and CC cord-010119-t1x9gknd 8104 42 was be VBD cord-010119-t1x9gknd 8104 43 positive positive JJ cord-010119-t1x9gknd 8104 44 . . . cord-010119-t1x9gknd 8105 1 Study Study NNP cord-010119-t1x9gknd 8105 2 Design Design NNP cord-010119-t1x9gknd 8105 3 / / SYM cord-010119-t1x9gknd 8105 4 Method method NN cord-010119-t1x9gknd 8105 5 : : : cord-010119-t1x9gknd 8106 1 A a DT cord-010119-t1x9gknd 8106 2 59-year 59-year JJ cord-010119-t1x9gknd 8106 3 - - HYPH cord-010119-t1x9gknd 8106 4 old old JJ cord-010119-t1x9gknd 8106 5 woman woman NN cord-010119-t1x9gknd 8106 6 with with IN cord-010119-t1x9gknd 8106 7 severe severe JJ cord-010119-t1x9gknd 8106 8 aplastic aplastic JJ cord-010119-t1x9gknd 8106 9 anemia anemia NN cord-010119-t1x9gknd 8106 10 experienced experience VBD cord-010119-t1x9gknd 8106 11 acute acute JJ cord-010119-t1x9gknd 8106 12 hemolytic hemolytic JJ cord-010119-t1x9gknd 8106 13 transfusion transfusion NN cord-010119-t1x9gknd 8106 14 reactions reaction NNS cord-010119-t1x9gknd 8106 15 ( ( -LRB- cord-010119-t1x9gknd 8106 16 AHTR AHTR NNP cord-010119-t1x9gknd 8106 17 ) ) -RRB- cord-010119-t1x9gknd 8106 18 with with IN cord-010119-t1x9gknd 8106 19 development development NN cord-010119-t1x9gknd 8106 20 of of IN cord-010119-t1x9gknd 8106 21 a a DT cord-010119-t1x9gknd 8106 22 panagglutinin panagglutinin NN cord-010119-t1x9gknd 8106 23 on on IN cord-010119-t1x9gknd 8106 24 indirect indirect JJ cord-010119-t1x9gknd 8106 25 antiglobulin antiglobulin NN cord-010119-t1x9gknd 8106 26 test test NN cord-010119-t1x9gknd 8106 27 ( ( -LRB- cord-010119-t1x9gknd 8106 28 IAT IAT NNP cord-010119-t1x9gknd 8106 29 ) ) -RRB- cord-010119-t1x9gknd 8106 30 screens screen NNS cord-010119-t1x9gknd 8106 31 . . . cord-010119-t1x9gknd 8107 1 Prior prior RB cord-010119-t1x9gknd 8107 2 to to IN cord-010119-t1x9gknd 8107 3 identifying identify VBG cord-010119-t1x9gknd 8107 4 the the DT cord-010119-t1x9gknd 8107 5 specificity specificity NN cord-010119-t1x9gknd 8107 6 of of IN cord-010119-t1x9gknd 8107 7 the the DT cord-010119-t1x9gknd 8107 8 panreactive panreactive JJ cord-010119-t1x9gknd 8107 9 antibody antibody NN cord-010119-t1x9gknd 8107 10 , , , cord-010119-t1x9gknd 8107 11 the the DT cord-010119-t1x9gknd 8107 12 patient patient NN cord-010119-t1x9gknd 8107 13 received receive VBD cord-010119-t1x9gknd 8107 14 10 10 CD cord-010119-t1x9gknd 8107 15 RBC RBC NNP cord-010119-t1x9gknd 8107 16 transfusions transfusion NNS cord-010119-t1x9gknd 8107 17 and and CC cord-010119-t1x9gknd 8107 18 showed show VBD cord-010119-t1x9gknd 8107 19 signs sign NNS cord-010119-t1x9gknd 8107 20 of of IN cord-010119-t1x9gknd 8107 21 hemolysis hemolysis NN cord-010119-t1x9gknd 8107 22 with with IN cord-010119-t1x9gknd 8107 23 six six CD cord-010119-t1x9gknd 8107 24 of of IN cord-010119-t1x9gknd 8107 25 them -PRON- PRP cord-010119-t1x9gknd 8107 26 . . . cord-010119-t1x9gknd 8108 1 The the DT cord-010119-t1x9gknd 8108 2 first first JJ cord-010119-t1x9gknd 8108 3 three three CD cord-010119-t1x9gknd 8108 4 transfusions transfusion NNS cord-010119-t1x9gknd 8108 5 were be VBD cord-010119-t1x9gknd 8108 6 prior prior RB cord-010119-t1x9gknd 8108 7 to to IN cord-010119-t1x9gknd 8108 8 her -PRON- PRP$ cord-010119-t1x9gknd 8108 9 positive positive JJ cord-010119-t1x9gknd 8108 10 IAT iat NN cord-010119-t1x9gknd 8108 11 and and CC cord-010119-t1x9gknd 8108 12 were be VBD cord-010119-t1x9gknd 8108 13 electronically electronically RB cord-010119-t1x9gknd 8108 14 crossmatched crossmatche VBN cord-010119-t1x9gknd 8108 15 . . . cord-010119-t1x9gknd 8109 1 The the DT cord-010119-t1x9gknd 8109 2 next next JJ cord-010119-t1x9gknd 8109 3 seven seven CD cord-010119-t1x9gknd 8109 4 transfusions transfusion NNS cord-010119-t1x9gknd 8109 5 were be VBD cord-010119-t1x9gknd 8109 6 incompatible incompatible JJ cord-010119-t1x9gknd 8109 7 by by IN cord-010119-t1x9gknd 8109 8 antihuman antihuman JJ cord-010119-t1x9gknd 8109 9 globulin globulin NN cord-010119-t1x9gknd 8109 10 ( ( -LRB- cord-010119-t1x9gknd 8109 11 AHG AHG NNP cord-010119-t1x9gknd 8109 12 ) ) -RRB- cord-010119-t1x9gknd 8109 13 phase phase NN cord-010119-t1x9gknd 8109 14 crossmatch crossmatch NN cord-010119-t1x9gknd 8109 15 , , , cord-010119-t1x9gknd 8109 16 but but CC cord-010119-t1x9gknd 8109 17 were be VBD cord-010119-t1x9gknd 8109 18 extended extend VBN cord-010119-t1x9gknd 8109 19 phenomatched phenomatched JJ cord-010119-t1x9gknd 8109 20 for for IN cord-010119-t1x9gknd 8109 21 clinically clinically RB cord-010119-t1x9gknd 8109 22 significant significant JJ cord-010119-t1x9gknd 8109 23 antigens antigen NNS cord-010119-t1x9gknd 8109 24 . . . cord-010119-t1x9gknd 8110 1 The the DT cord-010119-t1x9gknd 8110 2 patient patient NN cord-010119-t1x9gknd 8110 3 's 's POS cord-010119-t1x9gknd 8110 4 AHTR AHTR NNP cord-010119-t1x9gknd 8110 5 signs sign NNS cord-010119-t1x9gknd 8110 6 and and CC cord-010119-t1x9gknd 8110 7 symptoms symptom NNS cord-010119-t1x9gknd 8110 8 included include VBD cord-010119-t1x9gknd 8110 9 fever fever NN cord-010119-t1x9gknd 8110 10 , , , cord-010119-t1x9gknd 8110 11 rigors rigor NNS cord-010119-t1x9gknd 8110 12 , , , cord-010119-t1x9gknd 8110 13 nausea nausea NN cord-010119-t1x9gknd 8110 14 , , , cord-010119-t1x9gknd 8110 15 vomiting vomit VBG cord-010119-t1x9gknd 8110 16 , , , cord-010119-t1x9gknd 8110 17 dark dark JJ cord-010119-t1x9gknd 8110 18 urine urine NN cord-010119-t1x9gknd 8110 19 , , , cord-010119-t1x9gknd 8110 20 flank flank NN cord-010119-t1x9gknd 8110 21 pain pain NN cord-010119-t1x9gknd 8110 22 and and CC cord-010119-t1x9gknd 8110 23 " " `` cord-010119-t1x9gknd 8110 24 impending impending JJ cord-010119-t1x9gknd 8110 25 doom doom NN cord-010119-t1x9gknd 8110 26 " " '' cord-010119-t1x9gknd 8110 27 anxiety anxiety NN cord-010119-t1x9gknd 8110 28 ; ; : cord-010119-t1x9gknd 8110 29 while while IN cord-010119-t1x9gknd 8110 30 her -PRON- PRP$ cord-010119-t1x9gknd 8110 31 laboratory laboratory NN cord-010119-t1x9gknd 8110 32 findings finding NNS cord-010119-t1x9gknd 8110 33 included include VBD cord-010119-t1x9gknd 8110 34 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8110 35 decreasing decrease VBG cord-010119-t1x9gknd 8110 36 below below IN cord-010119-t1x9gknd 8110 37 pre pre JJ cord-010119-t1x9gknd 8110 38 - - JJ cord-010119-t1x9gknd 8110 39 transfusion transfusion JJ cord-010119-t1x9gknd 8110 40 levels level NNS cord-010119-t1x9gknd 8110 41 , , , cord-010119-t1x9gknd 8110 42 and and CC cord-010119-t1x9gknd 8110 43 increased increase VBD cord-010119-t1x9gknd 8110 44 total total JJ cord-010119-t1x9gknd 8110 45 bilirubin bilirubin NN cord-010119-t1x9gknd 8110 46 and and CC cord-010119-t1x9gknd 8110 47 LDH LDH NNP cord-010119-t1x9gknd 8110 48 . . . cord-010119-t1x9gknd 8111 1 The the DT cord-010119-t1x9gknd 8111 2 DAT DAT NNP cord-010119-t1x9gknd 8111 3 , , , cord-010119-t1x9gknd 8111 4 while while IN cord-010119-t1x9gknd 8111 5 initially initially RB cord-010119-t1x9gknd 8111 6 negative negative JJ cord-010119-t1x9gknd 8111 7 during during IN cord-010119-t1x9gknd 8111 8 the the DT cord-010119-t1x9gknd 8111 9 immediate immediate JJ cord-010119-t1x9gknd 8111 10 posttransfusion posttransfusion NN cord-010119-t1x9gknd 8111 11 workup workup NN cord-010119-t1x9gknd 8111 12 of of IN cord-010119-t1x9gknd 8111 13 the the DT cord-010119-t1x9gknd 8111 14 transfusion transfusion NN cord-010119-t1x9gknd 8111 15 reactions reaction NNS cord-010119-t1x9gknd 8111 16 , , , cord-010119-t1x9gknd 8111 17 eventually eventually RB cord-010119-t1x9gknd 8111 18 became become VBD cord-010119-t1x9gknd 8111 19 positive positive JJ cord-010119-t1x9gknd 8111 20 for for IN cord-010119-t1x9gknd 8111 21 IgG igg NN cord-010119-t1x9gknd 8111 22 only only RB cord-010119-t1x9gknd 8111 23 ( ( -LRB- cord-010119-t1x9gknd 8111 24 1 1 CD cord-010119-t1x9gknd 8111 25 - - SYM cord-010119-t1x9gknd 8111 26 21 21 CD cord-010119-t1x9gknd 8111 27 ) ) -RRB- cord-010119-t1x9gknd 8111 28 , , , cord-010119-t1x9gknd 8111 29 and and CC cord-010119-t1x9gknd 8111 30 negative negative JJ cord-010119-t1x9gknd 8111 31 with with IN cord-010119-t1x9gknd 8111 32 anti anti JJ cord-010119-t1x9gknd 8111 33 - - NNP cord-010119-t1x9gknd 8111 34 C3b C3b NNP cord-010119-t1x9gknd 8111 35 , , , cord-010119-t1x9gknd 8111 36 C3d C3d NNP cord-010119-t1x9gknd 8111 37 reagent reagent NN cord-010119-t1x9gknd 8111 38 . . . cord-010119-t1x9gknd 8112 1 The the DT cord-010119-t1x9gknd 8112 2 antibody antibody NN cord-010119-t1x9gknd 8112 3 showed show VBD cord-010119-t1x9gknd 8112 4 a a DT cord-010119-t1x9gknd 8112 5 peak peak NN cord-010119-t1x9gknd 8112 6 gel gel NN cord-010119-t1x9gknd 8112 7 - - HYPH cord-010119-t1x9gknd 8112 8 IgG igg NN cord-010119-t1x9gknd 8112 9 IAT IAT NNP cord-010119-t1x9gknd 8112 10 titer titer NN cord-010119-t1x9gknd 8112 11 of of IN cord-010119-t1x9gknd 8112 12 32 32 CD cord-010119-t1x9gknd 8112 13 . . . cord-010119-t1x9gknd 8113 1 Results/ Results/ . cord-010119-t1x9gknd 8114 1 Finding finding NN cord-010119-t1x9gknd 8114 2 : : : cord-010119-t1x9gknd 8115 1 The the DT cord-010119-t1x9gknd 8115 2 antibody antibody NN cord-010119-t1x9gknd 8115 3 was be VBD cord-010119-t1x9gknd 8115 4 identified identify VBN cord-010119-t1x9gknd 8115 5 as as IN cord-010119-t1x9gknd 8115 6 having have VBG cord-010119-t1x9gknd 8115 7 AnWj AnWj NNP cord-010119-t1x9gknd 8115 8 specificity specificity NN cord-010119-t1x9gknd 8115 9 . . . cord-010119-t1x9gknd 8116 1 The the DT cord-010119-t1x9gknd 8116 2 patient patient NN cord-010119-t1x9gknd 8116 3 's 's POS cord-010119-t1x9gknd 8116 4 pre pre JJ cord-010119-t1x9gknd 8116 5 - - JJ cord-010119-t1x9gknd 8116 6 transfusion transfusion JJ cord-010119-t1x9gknd 8116 7 sample sample NN cord-010119-t1x9gknd 8116 8 showed show VBD cord-010119-t1x9gknd 8116 9 weak weak JJ cord-010119-t1x9gknd 8116 10 AnWj AnWj NNP cord-010119-t1x9gknd 8116 11 expression expression NN cord-010119-t1x9gknd 8116 12 ( ( -LRB- cord-010119-t1x9gknd 8116 13 w1 w1 NNP cord-010119-t1x9gknd 8116 14 ) ) -RRB- cord-010119-t1x9gknd 8116 15 , , , cord-010119-t1x9gknd 8116 16 altogether altogether RB cord-010119-t1x9gknd 8116 17 suggesting suggest VBG cord-010119-t1x9gknd 8116 18 an an DT cord-010119-t1x9gknd 8116 19 auto auto NN cord-010119-t1x9gknd 8116 20 - - HYPH cord-010119-t1x9gknd 8116 21 anti anti NN cord-010119-t1x9gknd 8116 22 - - JJ cord-010119-t1x9gknd 8116 23 AnWj AnWj NNP cord-010119-t1x9gknd 8116 24 . . . cord-010119-t1x9gknd 8117 1 Monocyte Monocyte NNP cord-010119-t1x9gknd 8117 2 monolayer monolayer NN cord-010119-t1x9gknd 8117 3 assay assay NN cord-010119-t1x9gknd 8117 4 testing testing NN cord-010119-t1x9gknd 8117 5 using use VBG cord-010119-t1x9gknd 8117 6 the the DT cord-010119-t1x9gknd 8117 7 patient patient NN cord-010119-t1x9gknd 8117 8 's 's POS cord-010119-t1x9gknd 8117 9 plasma plasma NN cord-010119-t1x9gknd 8117 10 and and CC cord-010119-t1x9gknd 8117 11 RBCs rbc NNS cord-010119-t1x9gknd 8117 12 from from IN cord-010119-t1x9gknd 8117 13 the the DT cord-010119-t1x9gknd 8117 14 AHTR AHTR NNP cord-010119-t1x9gknd 8117 15 - - HYPH cord-010119-t1x9gknd 8117 16 implicated implicate VBN cord-010119-t1x9gknd 8117 17 units unit NNS cord-010119-t1x9gknd 8117 18 yielded yield VBD cord-010119-t1x9gknd 8117 19 monocyte monocyte NNP cord-010119-t1x9gknd 8117 20 indices index NNS cord-010119-t1x9gknd 8117 21 ranging range VBG cord-010119-t1x9gknd 8117 22 from from IN cord-010119-t1x9gknd 8117 23 33 33 CD cord-010119-t1x9gknd 8117 24 to to TO cord-010119-t1x9gknd 8117 25 83 83 CD cord-010119-t1x9gknd 8117 26 % % NN cord-010119-t1x9gknd 8117 27 , , , cord-010119-t1x9gknd 8117 28 consistent consistent JJ cord-010119-t1x9gknd 8117 29 with with IN cord-010119-t1x9gknd 8117 30 the the DT cord-010119-t1x9gknd 8117 31 clinical clinical JJ cord-010119-t1x9gknd 8117 32 hemolysis hemolysis NN cord-010119-t1x9gknd 8117 33 observed observe VBN cord-010119-t1x9gknd 8117 34 . . . cord-010119-t1x9gknd 8118 1 Given give VBN cord-010119-t1x9gknd 8118 2 the the DT cord-010119-t1x9gknd 8118 3 patient patient NN cord-010119-t1x9gknd 8118 4 's 's POS cord-010119-t1x9gknd 8118 5 group group NN cord-010119-t1x9gknd 8118 6 O O NNP cord-010119-t1x9gknd 8118 7 , , , cord-010119-t1x9gknd 8118 8 Rh Rh NNP cord-010119-t1x9gknd 8118 9 D D NNP cord-010119-t1x9gknd 8118 10 negative negative JJ cord-010119-t1x9gknd 8118 11 blood blood NN cord-010119-t1x9gknd 8118 12 type type NN cord-010119-t1x9gknd 8118 13 and and CC cord-010119-t1x9gknd 8118 14 continuing continue VBG cord-010119-t1x9gknd 8118 15 transfusion transfusion NN cord-010119-t1x9gknd 8118 16 dependence dependence NN cord-010119-t1x9gknd 8118 17 , , , cord-010119-t1x9gknd 8118 18 in in IN cord-010119-t1x9gknd 8118 19 order order NN cord-010119-t1x9gknd 8118 20 to to TO cord-010119-t1x9gknd 8118 21 avoid avoid VB cord-010119-t1x9gknd 8118 22 further further JJ cord-010119-t1x9gknd 8118 23 AHTRs ahtr NNS cord-010119-t1x9gknd 8118 24 , , , cord-010119-t1x9gknd 8118 25 international international JJ cord-010119-t1x9gknd 8118 26 collaboration collaboration NN cord-010119-t1x9gknd 8118 27 was be VBD cord-010119-t1x9gknd 8118 28 necessary necessary JJ cord-010119-t1x9gknd 8118 29 in in IN cord-010119-t1x9gknd 8118 30 order order NN cord-010119-t1x9gknd 8118 31 to to TO cord-010119-t1x9gknd 8118 32 procure procure VB cord-010119-t1x9gknd 8118 33 and and CC cord-010119-t1x9gknd 8118 34 provision provision NN cord-010119-t1x9gknd 8118 35 group group NN cord-010119-t1x9gknd 8118 36 O O NNP cord-010119-t1x9gknd 8118 37 , , , cord-010119-t1x9gknd 8118 38 Rh Rh NNP cord-010119-t1x9gknd 8118 39 D D NNP cord-010119-t1x9gknd 8118 40 negative negative JJ cord-010119-t1x9gknd 8118 41 RBCs rbc NNS cord-010119-t1x9gknd 8118 42 that that WDT cord-010119-t1x9gknd 8118 43 were be VBD cord-010119-t1x9gknd 8118 44 also also RB cord-010119-t1x9gknd 8118 45 serologically serologically RB cord-010119-t1x9gknd 8118 46 negative negative JJ cord-010119-t1x9gknd 8118 47 for for IN cord-010119-t1x9gknd 8118 48 AnWj AnWj NNP cord-010119-t1x9gknd 8118 49 . . . cord-010119-t1x9gknd 8119 1 The the DT cord-010119-t1x9gknd 8119 2 patient patient NN cord-010119-t1x9gknd 8119 3 was be VBD cord-010119-t1x9gknd 8119 4 successfully successfully RB cord-010119-t1x9gknd 8119 5 transfused transfuse VBN cord-010119-t1x9gknd 8119 6 three three CD cord-010119-t1x9gknd 8119 7 such such JJ cord-010119-t1x9gknd 8119 8 units unit NNS cord-010119-t1x9gknd 8119 9 without without IN cord-010119-t1x9gknd 8119 10 further further JJ cord-010119-t1x9gknd 8119 11 incident incident NN cord-010119-t1x9gknd 8119 12 . . . cord-010119-t1x9gknd 8120 1 Conclusion conclusion NN cord-010119-t1x9gknd 8120 2 : : : cord-010119-t1x9gknd 8121 1 This this DT cord-010119-t1x9gknd 8121 2 is be VBZ cord-010119-t1x9gknd 8121 3 the the DT cord-010119-t1x9gknd 8121 4 second second JJ cord-010119-t1x9gknd 8121 5 documented document VBN cord-010119-t1x9gknd 8121 6 case case NN cord-010119-t1x9gknd 8121 7 of of IN cord-010119-t1x9gknd 8121 8 anti anti JJ cord-010119-t1x9gknd 8121 9 - - JJ cord-010119-t1x9gknd 8121 10 AnWj anwj NN cord-010119-t1x9gknd 8121 11 in in IN cord-010119-t1x9gknd 8121 12 a a DT cord-010119-t1x9gknd 8121 13 patient patient NN cord-010119-t1x9gknd 8121 14 with with IN cord-010119-t1x9gknd 8121 15 aplastic aplastic JJ cord-010119-t1x9gknd 8121 16 anemia anemia NN cord-010119-t1x9gknd 8121 17 and and CC cord-010119-t1x9gknd 8121 18 , , , cord-010119-t1x9gknd 8121 19 overall overall RB cord-010119-t1x9gknd 8121 20 , , , cord-010119-t1x9gknd 8121 21 the the DT cord-010119-t1x9gknd 8121 22 third third JJ cord-010119-t1x9gknd 8121 23 anti anti JJ cord-010119-t1x9gknd 8121 24 - - JJ cord-010119-t1x9gknd 8121 25 AnWj anwj JJ cord-010119-t1x9gknd 8121 26 case case NN cord-010119-t1x9gknd 8121 27 associated associate VBN cord-010119-t1x9gknd 8121 28 with with IN cord-010119-t1x9gknd 8121 29 AHTR AHTR NNP cord-010119-t1x9gknd 8121 30 . . . cord-010119-t1x9gknd 8122 1 This this DT cord-010119-t1x9gknd 8122 2 case case NN cord-010119-t1x9gknd 8122 3 also also RB cord-010119-t1x9gknd 8122 4 underscores underscore VBZ cord-010119-t1x9gknd 8122 5 the the DT cord-010119-t1x9gknd 8122 6 importance importance NN cord-010119-t1x9gknd 8122 7 of of IN cord-010119-t1x9gknd 8122 8 international international JJ cord-010119-t1x9gknd 8122 9 collaboration collaboration NN cord-010119-t1x9gknd 8122 10 . . . cord-010119-t1x9gknd 8123 1 Cold cold JJ cord-010119-t1x9gknd 8123 2 auto auto NN cord-010119-t1x9gknd 8123 3 - - HYPH cord-010119-t1x9gknd 8123 4 antibody antibody NN cord-010119-t1x9gknd 8123 5 12 12 CD cord-010119-t1x9gknd 8123 6 Anti Anti NNP cord-010119-t1x9gknd 8123 7 - - NNP cord-010119-t1x9gknd 8123 8 P P NNP cord-010119-t1x9gknd 8123 9 1 1 CD cord-010119-t1x9gknd 8123 10 4 4 CD cord-010119-t1x9gknd 8123 11 Anti Anti NNP cord-010119-t1x9gknd 8123 12 - - NNP cord-010119-t1x9gknd 8123 13 M M NNP cord-010119-t1x9gknd 8123 14 2 2 CD cord-010119-t1x9gknd 8123 15 Anti Anti NNP cord-010119-t1x9gknd 8123 16 - - NNP cord-010119-t1x9gknd 8123 17 Sd Sd NNP cord-010119-t1x9gknd 8124 1 a a DT cord-010119-t1x9gknd 8124 2 6 6 CD cord-010119-t1x9gknd 8124 3 Anti Anti NNP cord-010119-t1x9gknd 8124 4 - - NNP cord-010119-t1x9gknd 8124 5 Le Le NNP cord-010119-t1x9gknd 8124 6 b b NNP cord-010119-t1x9gknd 8124 7 1 1 CD cord-010119-t1x9gknd 8124 8 Anti Anti NNP cord-010119-t1x9gknd 8124 9 - - NNP cord-010119-t1x9gknd 8124 10 Jk Jk NNP cord-010119-t1x9gknd 8125 1 a a DT cord-010119-t1x9gknd 8125 2 1 1 CD cord-010119-t1x9gknd 8125 3 Anti Anti NNP cord-010119-t1x9gknd 8125 4 - - JJ cord-010119-t1x9gknd 8125 5 K K NNP cord-010119-t1x9gknd 8125 6 1 1 CD cord-010119-t1x9gknd 8125 7 Anti Anti NNP cord-010119-t1x9gknd 8125 8 - - NNP cord-010119-t1x9gknd 8125 9 E E NNP cord-010119-t1x9gknd 8125 10 1 1 CD cord-010119-t1x9gknd 8125 11 Anti Anti NNP cord-010119-t1x9gknd 8125 12 - - NNP cord-010119-t1x9gknd 8125 13 C C NNP cord-010119-t1x9gknd 8125 14 1 1 CD cord-010119-t1x9gknd 8125 15 Results result NNS cord-010119-t1x9gknd 8125 16 / / SYM cord-010119-t1x9gknd 8125 17 Finding finding NN cord-010119-t1x9gknd 8125 18 : : : cord-010119-t1x9gknd 8125 19 Three three CD cord-010119-t1x9gknd 8125 20 hundred hundred CD cord-010119-t1x9gknd 8125 21 and and CC cord-010119-t1x9gknd 8125 22 ninety ninety CD cord-010119-t1x9gknd 8125 23 weak weak JJ cord-010119-t1x9gknd 8125 24 D d NN cord-010119-t1x9gknd 8125 25 genotypes genotype NNS cord-010119-t1x9gknd 8125 26 have have VBP cord-010119-t1x9gknd 8125 27 been be VBN cord-010119-t1x9gknd 8125 28 determined determine VBN cord-010119-t1x9gknd 8125 29 to to IN cord-010119-t1x9gknd 8125 30 this this DT cord-010119-t1x9gknd 8125 31 day day NN cord-010119-t1x9gknd 8125 32 with with IN cord-010119-t1x9gknd 8125 33 frequencies frequency NNS cord-010119-t1x9gknd 8125 34 of of IN cord-010119-t1x9gknd 8125 35 21 21 CD cord-010119-t1x9gknd 8125 36 % % NN cord-010119-t1x9gknd 8125 37 ( ( -LRB- cord-010119-t1x9gknd 8125 38 type type NN cord-010119-t1x9gknd 8125 39 1 1 CD cord-010119-t1x9gknd 8125 40 ) ) -RRB- cord-010119-t1x9gknd 8125 41 , , , cord-010119-t1x9gknd 8125 42 5 5 CD cord-010119-t1x9gknd 8125 43 % % NN cord-010119-t1x9gknd 8125 44 ( ( -LRB- cord-010119-t1x9gknd 8125 45 type type NN cord-010119-t1x9gknd 8125 46 2 2 CD cord-010119-t1x9gknd 8125 47 ) ) -RRB- cord-010119-t1x9gknd 8125 48 , , , cord-010119-t1x9gknd 8125 49 9 9 CD cord-010119-t1x9gknd 8125 50 % % NN cord-010119-t1x9gknd 8125 51 ( ( -LRB- cord-010119-t1x9gknd 8125 52 type type NN cord-010119-t1x9gknd 8125 53 3 3 CD cord-010119-t1x9gknd 8125 54 ) ) -RRB- cord-010119-t1x9gknd 8125 55 , , , cord-010119-t1x9gknd 8125 56 25 25 CD cord-010119-t1x9gknd 8125 57 % % NN cord-010119-t1x9gknd 8125 58 ( ( -LRB- cord-010119-t1x9gknd 8125 59 type type NN cord-010119-t1x9gknd 8125 60 42 42 CD cord-010119-t1x9gknd 8125 61 ) ) -RRB- cord-010119-t1x9gknd 8125 62 and and CC cord-010119-t1x9gknd 8125 63 40 40 CD cord-010119-t1x9gknd 8125 64 % % NN cord-010119-t1x9gknd 8125 65 other other JJ cord-010119-t1x9gknd 8125 66 than than IN cord-010119-t1x9gknd 8125 67 1 1 CD cord-010119-t1x9gknd 8125 68 , , , cord-010119-t1x9gknd 8125 69 2 2 CD cord-010119-t1x9gknd 8125 70 , , , cord-010119-t1x9gknd 8125 71 3 3 CD cord-010119-t1x9gknd 8125 72 or or CC cord-010119-t1x9gknd 8125 73 42 42 CD cord-010119-t1x9gknd 8125 74 . . . cord-010119-t1x9gknd 8126 1 Further further JJ cord-010119-t1x9gknd 8126 2 investigation investigation NN cord-010119-t1x9gknd 8126 3 was be VBD cord-010119-t1x9gknd 8126 4 conducted conduct VBN cord-010119-t1x9gknd 8126 5 to to TO cord-010119-t1x9gknd 8126 6 determine determine VB cord-010119-t1x9gknd 8126 7 the the DT cord-010119-t1x9gknd 8126 8 molecular molecular JJ cord-010119-t1x9gknd 8126 9 identity identity NN cord-010119-t1x9gknd 8126 10 of of IN cord-010119-t1x9gknd 8126 11 the the DT cord-010119-t1x9gknd 8126 12 « « `` cord-010119-t1x9gknd 8126 13 others other NNS cord-010119-t1x9gknd 8126 14 » » '' cord-010119-t1x9gknd 8126 15 . . . cord-010119-t1x9gknd 8127 1 Out out IN cord-010119-t1x9gknd 8127 2 of of IN cord-010119-t1x9gknd 8127 3 157 157 CD cord-010119-t1x9gknd 8127 4 samples sample NNS cord-010119-t1x9gknd 8127 5 , , , cord-010119-t1x9gknd 8127 6 119 119 CD cord-010119-t1x9gknd 8127 7 ( ( -LRB- cord-010119-t1x9gknd 8127 8 75 75 CD cord-010119-t1x9gknd 8127 9 % % NN cord-010119-t1x9gknd 8127 10 ) ) -RRB- cord-010119-t1x9gknd 8127 11 were be VBD cord-010119-t1x9gknd 8127 12 confirmed confirm VBN cord-010119-t1x9gknd 8127 13 to to TO cord-010119-t1x9gknd 8127 14 be be VB cord-010119-t1x9gknd 8127 15 legitimate legitimate JJ cord-010119-t1x9gknd 8127 16 serological serological JJ cord-010119-t1x9gknd 8127 17 weak weak JJ cord-010119-t1x9gknd 8127 18 or or CC cord-010119-t1x9gknd 8127 19 partial partial JJ cord-010119-t1x9gknd 8127 20 D d NN cord-010119-t1x9gknd 8127 21 , , , cord-010119-t1x9gknd 8127 22 mainly mainly RB cord-010119-t1x9gknd 8127 23 deletions deletion NNS cord-010119-t1x9gknd 8127 24 of of IN cord-010119-t1x9gknd 8127 25 exon exon NN cord-010119-t1x9gknd 8127 26 5 5 CD cord-010119-t1x9gknd 8127 27 or or CC cord-010119-t1x9gknd 8127 28 both both DT cord-010119-t1x9gknd 8127 29 exons exon NNS cord-010119-t1x9gknd 8127 30 4 4 CD cord-010119-t1x9gknd 8127 31 and and CC cord-010119-t1x9gknd 8127 32 5 5 CD cord-010119-t1x9gknd 8127 33 . . . cord-010119-t1x9gknd 8128 1 A a DT cord-010119-t1x9gknd 8128 2 surprising surprising JJ cord-010119-t1x9gknd 8128 3 amount amount NN cord-010119-t1x9gknd 8128 4 of of IN cord-010119-t1x9gknd 8128 5 38 38 CD cord-010119-t1x9gknd 8128 6 samples sample NNS cord-010119-t1x9gknd 8128 7 were be VBD cord-010119-t1x9gknd 8128 8 discovered discover VBN cord-010119-t1x9gknd 8128 9 to to TO cord-010119-t1x9gknd 8128 10 be be VB cord-010119-t1x9gknd 8128 11 normal normal JJ cord-010119-t1x9gknd 8128 12 RHD RHD NNP cord-010119-t1x9gknd 8128 13 . . . cord-010119-t1x9gknd 8129 1 Conclusion conclusion NN cord-010119-t1x9gknd 8129 2 : : : cord-010119-t1x9gknd 8130 1 Along along IN cord-010119-t1x9gknd 8130 2 with with IN cord-010119-t1x9gknd 8130 3 Sandler Sandler NNP cord-010119-t1x9gknd 8130 4 et et NNP cord-010119-t1x9gknd 8130 5 al al NNP cord-010119-t1x9gknd 8130 6 . . . cord-010119-t1x9gknd 8131 1 ( ( -LRB- cord-010119-t1x9gknd 8131 2 2015 2015 CD cord-010119-t1x9gknd 8131 3 ) ) -RRB- cord-010119-t1x9gknd 8131 4 data datum NNS cord-010119-t1x9gknd 8131 5 , , , cord-010119-t1x9gknd 8131 6 our -PRON- PRP$ cord-010119-t1x9gknd 8131 7 findings finding NNS cord-010119-t1x9gknd 8131 8 highlight highlight VBP cord-010119-t1x9gknd 8131 9 the the DT cord-010119-t1x9gknd 8131 10 difficulties difficulty NNS cord-010119-t1x9gknd 8131 11 hospitals hospital NNS cord-010119-t1x9gknd 8131 12 face face VBP cord-010119-t1x9gknd 8131 13 in in IN cord-010119-t1x9gknd 8131 14 interpreting interpret VBG cord-010119-t1x9gknd 8131 15 serological serological JJ cord-010119-t1x9gknd 8131 16 weak weak JJ cord-010119-t1x9gknd 8131 17 D. D. NNP cord-010119-t1x9gknd 8131 18 Trend Trend NNP cord-010119-t1x9gknd 8131 19 analysis analysis NN cord-010119-t1x9gknd 8131 20 was be VBD cord-010119-t1x9gknd 8131 21 conducted conduct VBN cord-010119-t1x9gknd 8131 22 regarding regard VBG cord-010119-t1x9gknd 8131 23 the the DT cord-010119-t1x9gknd 8131 24 reagents reagent NNS cord-010119-t1x9gknd 8131 25 and and CC cord-010119-t1x9gknd 8131 26 technologies technology NNS cord-010119-t1x9gknd 8131 27 used use VBN cord-010119-t1x9gknd 8131 28 by by IN cord-010119-t1x9gknd 8131 29 each each DT cord-010119-t1x9gknd 8131 30 hospital hospital NN cord-010119-t1x9gknd 8131 31 , , , cord-010119-t1x9gknd 8131 32 the the DT cord-010119-t1x9gknd 8131 33 origin origin NN cord-010119-t1x9gknd 8131 34 of of IN cord-010119-t1x9gknd 8131 35 the the DT cord-010119-t1x9gknd 8131 36 request request NN cord-010119-t1x9gknd 8131 37 and and CC cord-010119-t1x9gknd 8131 38 the the DT cord-010119-t1x9gknd 8131 39 ethnicity ethnicity NN cord-010119-t1x9gknd 8131 40 of of IN cord-010119-t1x9gknd 8131 41 the the DT cord-010119-t1x9gknd 8131 42 concerned concerned JJ cord-010119-t1x9gknd 8131 43 patient patient NN cord-010119-t1x9gknd 8131 44 , , , cord-010119-t1x9gknd 8131 45 but but CC cord-010119-t1x9gknd 8131 46 no no DT cord-010119-t1x9gknd 8131 47 significant significant JJ cord-010119-t1x9gknd 8131 48 correlation correlation NN cord-010119-t1x9gknd 8131 49 could could MD cord-010119-t1x9gknd 8131 50 be be VB cord-010119-t1x9gknd 8131 51 identified identify VBN cord-010119-t1x9gknd 8131 52 at at IN cord-010119-t1x9gknd 8131 53 this this DT cord-010119-t1x9gknd 8131 54 point point NN cord-010119-t1x9gknd 8131 55 . . . cord-010119-t1x9gknd 8132 1 Altogether altogether RB cord-010119-t1x9gknd 8132 2 , , , cord-010119-t1x9gknd 8132 3 our -PRON- PRP$ cord-010119-t1x9gknd 8132 4 findings finding NNS cord-010119-t1x9gknd 8132 5 allow allow VBP cord-010119-t1x9gknd 8132 6 to to TO cord-010119-t1x9gknd 8132 7 share share VB cord-010119-t1x9gknd 8132 8 the the DT cord-010119-t1x9gknd 8132 9 frequency frequency NN cord-010119-t1x9gknd 8132 10 of of IN cord-010119-t1x9gknd 8132 11 weak weak JJ cord-010119-t1x9gknd 8132 12 D d NN cord-010119-t1x9gknd 8132 13 types type NNS cord-010119-t1x9gknd 8132 14 1 1 CD cord-010119-t1x9gknd 8132 15 , , , cord-010119-t1x9gknd 8132 16 2 2 CD cord-010119-t1x9gknd 8132 17 , , , cord-010119-t1x9gknd 8132 18 3 3 CD cord-010119-t1x9gknd 8132 19 and and CC cord-010119-t1x9gknd 8132 20 42 42 CD cord-010119-t1x9gknd 8132 21 obtained obtain VBN cord-010119-t1x9gknd 8132 22 in in IN cord-010119-t1x9gknd 8132 23 serological serological JJ cord-010119-t1x9gknd 8132 24 weak weak JJ cord-010119-t1x9gknd 8132 25 D d NN cord-010119-t1x9gknd 8132 26 , , , cord-010119-t1x9gknd 8132 27 45 45 CD cord-010119-t1x9gknd 8132 28 years year NNS cord-010119-t1x9gknd 8132 29 old old JJ cord-010119-t1x9gknd 8132 30 Quebec Quebec NNP cord-010119-t1x9gknd 8132 31 's 's POS cord-010119-t1x9gknd 8132 32 women woman NNS cord-010119-t1x9gknd 8132 33 , , , cord-010119-t1x9gknd 8132 34 and and CC cord-010119-t1x9gknd 8132 35 also also RB cord-010119-t1x9gknd 8132 36 highlight highlight VB cord-010119-t1x9gknd 8132 37 the the DT cord-010119-t1x9gknd 8132 38 need need NN cord-010119-t1x9gknd 8132 39 for for IN cord-010119-t1x9gknd 8132 40 further further JJ cord-010119-t1x9gknd 8132 41 investigation investigation NN cord-010119-t1x9gknd 8132 42 of of IN cord-010119-t1x9gknd 8132 43 standard standard JJ cord-010119-t1x9gknd 8132 44 practices practice NNS cord-010119-t1x9gknd 8132 45 amongst amongst IN cord-010119-t1x9gknd 8132 46 hospitals hospital NNS cord-010119-t1x9gknd 8132 47 regarding regard VBG cord-010119-t1x9gknd 8132 48 the the DT cord-010119-t1x9gknd 8132 49 management management NN cord-010119-t1x9gknd 8132 50 and and CC cord-010119-t1x9gknd 8132 51 interpretation interpretation NN cord-010119-t1x9gknd 8132 52 of of IN cord-010119-t1x9gknd 8132 53 atypical atypical JJ cord-010119-t1x9gknd 8132 54 D d NN cord-010119-t1x9gknd 8132 55 typing typing NN cord-010119-t1x9gknd 8132 56 . . . cord-010119-t1x9gknd 8132 57 were be VBD cord-010119-t1x9gknd 8132 58 classified classify VBN cord-010119-t1x9gknd 8132 59 as as IN cord-010119-t1x9gknd 8132 60 FNHTR FNHTR NNP cord-010119-t1x9gknd 8132 61 . . . cord-010119-t1x9gknd 8133 1 TACO taco NN cord-010119-t1x9gknd 8133 2 incidence incidence NN cord-010119-t1x9gknd 8133 3 was be VBD cord-010119-t1x9gknd 8133 4 0,6 0,6 CD cord-010119-t1x9gknd 8133 5 % % NN cord-010119-t1x9gknd 8133 6 . . . cord-010119-t1x9gknd 8134 1 No no DT cord-010119-t1x9gknd 8134 2 TRALI TRALI NNP cord-010119-t1x9gknd 8134 3 happened happen VBD cord-010119-t1x9gknd 8134 4 in in IN cord-010119-t1x9gknd 8134 5 the the DT cord-010119-t1x9gknd 8134 6 period period NN cord-010119-t1x9gknd 8134 7 . . . cord-010119-t1x9gknd 8135 1 Prophylaxis Prophylaxis NNP cord-010119-t1x9gknd 8135 2 were be VBD cord-010119-t1x9gknd 8135 3 used use VBN cord-010119-t1x9gknd 8135 4 in in IN cord-010119-t1x9gknd 8135 5 98 98 CD cord-010119-t1x9gknd 8135 6 % % NN cord-010119-t1x9gknd 8135 7 of of IN cord-010119-t1x9gknd 8135 8 patients patient NNS cord-010119-t1x9gknd 8135 9 . . . cord-010119-t1x9gknd 8136 1 Conclusion conclusion NN cord-010119-t1x9gknd 8136 2 : : : cord-010119-t1x9gknd 8137 1 FNHTR FNHTR NNP cord-010119-t1x9gknd 8137 2 is be VBZ cord-010119-t1x9gknd 8137 3 described describe VBN cord-010119-t1x9gknd 8137 4 as as IN cord-010119-t1x9gknd 8137 5 the the DT cord-010119-t1x9gknd 8137 6 most most RBS cord-010119-t1x9gknd 8137 7 common common JJ cord-010119-t1x9gknd 8137 8 adverse adverse JJ cord-010119-t1x9gknd 8137 9 event event NN cord-010119-t1x9gknd 8137 10 related relate VBN cord-010119-t1x9gknd 8137 11 to to IN cord-010119-t1x9gknd 8137 12 transfusion transfusion NN cord-010119-t1x9gknd 8137 13 , , , cord-010119-t1x9gknd 8137 14 but but CC cord-010119-t1x9gknd 8137 15 our -PRON- PRP$ cord-010119-t1x9gknd 8137 16 data datum NNS cord-010119-t1x9gknd 8137 17 showed show VBD cord-010119-t1x9gknd 8137 18 a a DT cord-010119-t1x9gknd 8137 19 higher high JJR cord-010119-t1x9gknd 8137 20 incidence incidence NN cord-010119-t1x9gknd 8137 21 of of IN cord-010119-t1x9gknd 8137 22 allergic allergic JJ cord-010119-t1x9gknd 8137 23 reactions reaction NNS cord-010119-t1x9gknd 8137 24 . . . cord-010119-t1x9gknd 8138 1 FNHTR FNHTR NNP cord-010119-t1x9gknd 8138 2 occurred occur VBD cord-010119-t1x9gknd 8138 3 3 3 CD cord-010119-t1x9gknd 8138 4 times time NNS cord-010119-t1x9gknd 8138 5 less less JJR cord-010119-t1x9gknd 8138 6 than than IN cord-010119-t1x9gknd 8138 7 allergic allergic JJ cord-010119-t1x9gknd 8138 8 reactions reaction NNS cord-010119-t1x9gknd 8138 9 . . . cord-010119-t1x9gknd 8139 1 This this DT cord-010119-t1x9gknd 8139 2 might may MD cord-010119-t1x9gknd 8139 3 be be VB cord-010119-t1x9gknd 8139 4 explained explain VBN cord-010119-t1x9gknd 8139 5 by by IN cord-010119-t1x9gknd 8139 6 universal universal JJ cord-010119-t1x9gknd 8139 7 leukoreduction leukoreduction NNP cord-010119-t1x9gknd 8139 8 and and CC cord-010119-t1x9gknd 8139 9 universal universal JJ cord-010119-t1x9gknd 8139 10 prophylaxis prophylaxis NN cord-010119-t1x9gknd 8139 11 adopted adopt VBN cord-010119-t1x9gknd 8139 12 at at IN cord-010119-t1x9gknd 8139 13 our -PRON- PRP$ cord-010119-t1x9gknd 8139 14 institution institution NN cord-010119-t1x9gknd 8139 15 . . . cord-010119-t1x9gknd 8140 1 Further further JJ cord-010119-t1x9gknd 8140 2 studies study NNS cord-010119-t1x9gknd 8140 3 are be VBP cord-010119-t1x9gknd 8140 4 necessary necessary JJ cord-010119-t1x9gknd 8140 5 to to TO cord-010119-t1x9gknd 8140 6 evaluated evaluate VBN cord-010119-t1x9gknd 8140 7 the the DT cord-010119-t1x9gknd 8140 8 benefit benefit NN cord-010119-t1x9gknd 8140 9 of of IN cord-010119-t1x9gknd 8140 10 this this DT cord-010119-t1x9gknd 8140 11 approach approach NN cord-010119-t1x9gknd 8140 12 . . . cord-010119-t1x9gknd 8141 1 that that DT cord-010119-t1x9gknd 8141 2 can can MD cord-010119-t1x9gknd 8141 3 not not RB cord-010119-t1x9gknd 8141 4 be be VB cord-010119-t1x9gknd 8141 5 associated associate VBN cord-010119-t1x9gknd 8141 6 with with IN cord-010119-t1x9gknd 8141 7 a a DT cord-010119-t1x9gknd 8141 8 specific specific JJ cord-010119-t1x9gknd 8141 9 RBC RBC NNP cord-010119-t1x9gknd 8141 10 unit unit NN cord-010119-t1x9gknd 8141 11 or or CC cord-010119-t1x9gknd 8141 12 were be VBD cord-010119-t1x9gknd 8141 13 deemed deem VBN cord-010119-t1x9gknd 8141 14 unrelated unrelated JJ cord-010119-t1x9gknd 8141 15 to to IN cord-010119-t1x9gknd 8141 16 transfusion transfusion NN cord-010119-t1x9gknd 8141 17 , , , cord-010119-t1x9gknd 8141 18 358 358 CD cord-010119-t1x9gknd 8141 19 RBC RBC NNP cord-010119-t1x9gknd 8141 20 transfusion transfusion NN cord-010119-t1x9gknd 8141 21 AEs ae NNS cord-010119-t1x9gknd 8141 22 were be VBD cord-010119-t1x9gknd 8141 23 analyzed analyze VBN cord-010119-t1x9gknd 8141 24 . . . cord-010119-t1x9gknd 8142 1 Chi Chi NNP cord-010119-t1x9gknd 8142 2 - - HYPH cord-010119-t1x9gknd 8142 3 square square JJ cord-010119-t1x9gknd 8142 4 test test NN cord-010119-t1x9gknd 8142 5 and and CC cord-010119-t1x9gknd 8142 6 logistic logistic JJ cord-010119-t1x9gknd 8142 7 regression regression NN cord-010119-t1x9gknd 8142 8 were be VBD cord-010119-t1x9gknd 8142 9 used use VBN cord-010119-t1x9gknd 8142 10 to to TO cord-010119-t1x9gknd 8142 11 compare compare VB cord-010119-t1x9gknd 8142 12 the the DT cord-010119-t1x9gknd 8142 13 AE AE NNP cord-010119-t1x9gknd 8142 14 incidences incidence NNS cord-010119-t1x9gknd 8142 15 among among IN cord-010119-t1x9gknd 8142 16 transfusion transfusion NN cord-010119-t1x9gknd 8142 17 groups group NNS cord-010119-t1x9gknd 8142 18 . . . cord-010119-t1x9gknd 8143 1 Results/ Results/ . cord-010119-t1x9gknd 8144 1 Finding finding NN cord-010119-t1x9gknd 8144 2 : : : cord-010119-t1x9gknd 8145 1 Univariate univariate JJ cord-010119-t1x9gknd 8145 2 and and CC cord-010119-t1x9gknd 8145 3 multivariate multivariate JJ cord-010119-t1x9gknd 8145 4 logistic logistic JJ cord-010119-t1x9gknd 8145 5 analyses analysis NNS cord-010119-t1x9gknd 8145 6 showed show VBD cord-010119-t1x9gknd 8145 7 that that IN cord-010119-t1x9gknd 8145 8 irradiated irradiate VBN cord-010119-t1x9gknd 8145 9 RBCs rbc NNS cord-010119-t1x9gknd 8145 10 were be VBD cord-010119-t1x9gknd 8145 11 associated associate VBN cord-010119-t1x9gknd 8145 12 with with IN cord-010119-t1x9gknd 8145 13 a a DT cord-010119-t1x9gknd 8145 14 significantly significantly RB cord-010119-t1x9gknd 8145 15 increased increase VBN cord-010119-t1x9gknd 8145 16 incidence incidence NN cord-010119-t1x9gknd 8145 17 of of IN cord-010119-t1x9gknd 8145 18 transfusion transfusion NN cord-010119-t1x9gknd 8145 19 - - HYPH cord-010119-t1x9gknd 8145 20 related relate VBN cord-010119-t1x9gknd 8145 21 AEs ae NNS cord-010119-t1x9gknd 8145 22 ( ( -LRB- cord-010119-t1x9gknd 8145 23 p p NN cord-010119-t1x9gknd 8145 24 < < XX cord-010119-t1x9gknd 8145 25 0.05 0.05 CD cord-010119-t1x9gknd 8145 26 ) ) -RRB- cord-010119-t1x9gknd 8145 27 . . . cord-010119-t1x9gknd 8146 1 There there EX cord-010119-t1x9gknd 8146 2 was be VBD cord-010119-t1x9gknd 8146 3 a a DT cord-010119-t1x9gknd 8146 4 significant significant JJ cord-010119-t1x9gknd 8146 5 difference difference NN cord-010119-t1x9gknd 8146 6 in in IN cord-010119-t1x9gknd 8146 7 febrile febrile JJ cord-010119-t1x9gknd 8146 8 non non JJ cord-010119-t1x9gknd 8146 9 - - JJ cord-010119-t1x9gknd 8146 10 hemolytic hemolytic JJ cord-010119-t1x9gknd 8146 11 transfusion transfusion NN cord-010119-t1x9gknd 8146 12 reaction reaction NN cord-010119-t1x9gknd 8146 13 ( ( -LRB- cord-010119-t1x9gknd 8146 14 FNHTR FNHTR NNP cord-010119-t1x9gknd 8146 15 ) ) -RRB- cord-010119-t1x9gknd 8146 16 ( ( -LRB- cord-010119-t1x9gknd 8146 17 0.27 0.27 CD cord-010119-t1x9gknd 8146 18 % % NN cord-010119-t1x9gknd 8146 19 vs vs IN cord-010119-t1x9gknd 8146 20 0.11 0.11 CD cord-010119-t1x9gknd 8146 21 % % NN cord-010119-t1x9gknd 8146 22 , , , cord-010119-t1x9gknd 8146 23 p p NN cord-010119-t1x9gknd 8146 24 < < XX cord-010119-t1x9gknd 8146 25 0.001 0.001 CD cord-010119-t1x9gknd 8146 26 ) ) -RRB- cord-010119-t1x9gknd 8146 27 or or CC cord-010119-t1x9gknd 8146 28 AEs ae NNS cord-010119-t1x9gknd 8146 29 with with IN cord-010119-t1x9gknd 8146 30 a a DT cord-010119-t1x9gknd 8146 31 non non JJ cord-010119-t1x9gknd 8146 32 - - JJ cord-010119-t1x9gknd 8146 33 allergic allergic JJ cord-010119-t1x9gknd 8146 34 type type NN cord-010119-t1x9gknd 8146 35 inflammation inflammation NN cord-010119-t1x9gknd 8146 36 etiology etiology NN cord-010119-t1x9gknd 8146 37 ( ( -LRB- cord-010119-t1x9gknd 8146 38 0.30 0.30 CD cord-010119-t1x9gknd 8146 39 % % NN cord-010119-t1x9gknd 8146 40 vs vs IN cord-010119-t1x9gknd 8146 41 0.14 0.14 CD cord-010119-t1x9gknd 8146 42 % % NN cord-010119-t1x9gknd 8146 43 , , , cord-010119-t1x9gknd 8146 44 p p NN cord-010119-t1x9gknd 8146 45 < < XX cord-010119-t1x9gknd 8146 46 0.001 0.001 CD cord-010119-t1x9gknd 8146 47 ) ) -RRB- cord-010119-t1x9gknd 8146 48 including include VBG cord-010119-t1x9gknd 8146 49 transfusion transfusion NN cord-010119-t1x9gknd 8146 50 - - HYPH cord-010119-t1x9gknd 8146 51 related relate VBN cord-010119-t1x9gknd 8146 52 acute acute JJ cord-010119-t1x9gknd 8146 53 lung lung NN cord-010119-t1x9gknd 8146 54 injury injury NN cord-010119-t1x9gknd 8146 55 , , , cord-010119-t1x9gknd 8146 56 transfusion transfusion NN cord-010119-t1x9gknd 8146 57 - - HYPH cord-010119-t1x9gknd 8146 58 associated associate VBN cord-010119-t1x9gknd 8146 59 dyspnea dyspnea NN cord-010119-t1x9gknd 8146 60 , , , cord-010119-t1x9gknd 8146 61 but but CC cord-010119-t1x9gknd 8146 62 not not RB cord-010119-t1x9gknd 8146 63 transfusion transfusion NN cord-010119-t1x9gknd 8146 64 - - HYPH cord-010119-t1x9gknd 8146 65 associated associate VBN cord-010119-t1x9gknd 8146 66 circulatory circulatory JJ cord-010119-t1x9gknd 8146 67 overload overload NN cord-010119-t1x9gknd 8146 68 , , , cord-010119-t1x9gknd 8146 69 infections infection NNS cord-010119-t1x9gknd 8146 70 or or CC cord-010119-t1x9gknd 8146 71 hemolytic hemolytic JJ cord-010119-t1x9gknd 8146 72 transfusion transfusion NN cord-010119-t1x9gknd 8146 73 reactions reaction NNS cord-010119-t1x9gknd 8146 74 , , , cord-010119-t1x9gknd 8146 75 between between IN cord-010119-t1x9gknd 8146 76 irradiated irradiated JJ cord-010119-t1x9gknd 8146 77 RBCs rbc NNS cord-010119-t1x9gknd 8146 78 and and CC cord-010119-t1x9gknd 8146 79 non non JJ cord-010119-t1x9gknd 8146 80 - - JJ cord-010119-t1x9gknd 8146 81 irradiated irradiated JJ cord-010119-t1x9gknd 8146 82 RBCs rbc NNS cord-010119-t1x9gknd 8146 83 . . . cord-010119-t1x9gknd 8147 1 In in IN cord-010119-t1x9gknd 8147 2 contrast contrast NN cord-010119-t1x9gknd 8147 3 , , , cord-010119-t1x9gknd 8147 4 the the DT cord-010119-t1x9gknd 8147 5 incidences incidence NNS cord-010119-t1x9gknd 8147 6 of of IN cord-010119-t1x9gknd 8147 7 allergic allergic JJ cord-010119-t1x9gknd 8147 8 AEs AEs NNP cord-010119-t1x9gknd 8147 9 ( ( -LRB- cord-010119-t1x9gknd 8147 10 0.028 0.028 CD cord-010119-t1x9gknd 8147 11 % % NN cord-010119-t1x9gknd 8147 12 vs vs IN cord-010119-t1x9gknd 8147 13 0.024 0.024 CD cord-010119-t1x9gknd 8147 14 % % NN cord-010119-t1x9gknd 8147 15 , , , cord-010119-t1x9gknd 8147 16 p p NN cord-010119-t1x9gknd 8147 17 5 5 CD cord-010119-t1x9gknd 8147 18 0.614 0.614 CD cord-010119-t1x9gknd 8147 19 ) ) -RRB- cord-010119-t1x9gknd 8147 20 were be VBD cord-010119-t1x9gknd 8147 21 similar similar JJ cord-010119-t1x9gknd 8147 22 between between IN cord-010119-t1x9gknd 8147 23 these these DT cord-010119-t1x9gknd 8147 24 two two CD cord-010119-t1x9gknd 8147 25 groups group NNS cord-010119-t1x9gknd 8147 26 . . . cord-010119-t1x9gknd 8148 1 The the DT cord-010119-t1x9gknd 8148 2 incidences incidence NNS cord-010119-t1x9gknd 8148 3 of of IN cord-010119-t1x9gknd 8148 4 inflammation inflammation NN cord-010119-t1x9gknd 8148 5 AEs ae NNS cord-010119-t1x9gknd 8148 6 after after IN cord-010119-t1x9gknd 8148 7 transfusion transfusion NN cord-010119-t1x9gknd 8148 8 of of IN cord-010119-t1x9gknd 8148 9 irradiated irradiated JJ cord-010119-t1x9gknd 8148 10 RBCs rbc NNS cord-010119-t1x9gknd 8148 11 that that WDT cord-010119-t1x9gknd 8148 12 were be VBD cord-010119-t1x9gknd 8148 13 stored store VBN cord-010119-t1x9gknd 8148 14 for for IN cord-010119-t1x9gknd 8148 15 1 1 CD cord-010119-t1x9gknd 8148 16 , , , cord-010119-t1x9gknd 8148 17 2 2 CD cord-010119-t1x9gknd 8148 18 , , , cord-010119-t1x9gknd 8148 19 3 3 CD cord-010119-t1x9gknd 8148 20 , , , cord-010119-t1x9gknd 8148 21 and and CC cord-010119-t1x9gknd 8148 22 4 4 CD cord-010119-t1x9gknd 8148 23 weeks week NNS cord-010119-t1x9gknd 8148 24 were be VBD cord-010119-t1x9gknd 8148 25 0.25 0.25 CD cord-010119-t1x9gknd 8148 26 % % NN cord-010119-t1x9gknd 8148 27 , , , cord-010119-t1x9gknd 8148 28 0.32 0.32 CD cord-010119-t1x9gknd 8148 29 % % NN cord-010119-t1x9gknd 8148 30 , , , cord-010119-t1x9gknd 8148 31 0.39 0.39 CD cord-010119-t1x9gknd 8148 32 % % NN cord-010119-t1x9gknd 8148 33 and and CC cord-010119-t1x9gknd 8148 34 0.41 0.41 CD cord-010119-t1x9gknd 8148 35 % % NN cord-010119-t1x9gknd 8148 36 , , , cord-010119-t1x9gknd 8148 37 respectively respectively RB cord-010119-t1x9gknd 8148 38 ( ( -LRB- cord-010119-t1x9gknd 8148 39 p p NN cord-010119-t1x9gknd 8148 40 5 5 CD cord-010119-t1x9gknd 8148 41 0.084 0.084 CD cord-010119-t1x9gknd 8148 42 , , , cord-010119-t1x9gknd 8148 43 logistic logistic JJ cord-010119-t1x9gknd 8148 44 regression regression NN cord-010119-t1x9gknd 8148 45 ) ) -RRB- cord-010119-t1x9gknd 8148 46 but but CC cord-010119-t1x9gknd 8148 47 there there EX cord-010119-t1x9gknd 8148 48 was be VBD cord-010119-t1x9gknd 8148 49 a a DT cord-010119-t1x9gknd 8148 50 significant significant JJ cord-010119-t1x9gknd 8148 51 difference difference NN cord-010119-t1x9gknd 8148 52 in in IN cord-010119-t1x9gknd 8148 53 the the DT cord-010119-t1x9gknd 8148 54 incidence incidence NN cord-010119-t1x9gknd 8148 55 of of IN cord-010119-t1x9gknd 8148 56 inflammation inflammation NN cord-010119-t1x9gknd 8148 57 AEs ae NNS cord-010119-t1x9gknd 8148 58 caused cause VBN cord-010119-t1x9gknd 8148 59 by by IN cord-010119-t1x9gknd 8148 60 irradiated irradiate VBN cord-010119-t1x9gknd 8148 61 RBCs rbc NNS cord-010119-t1x9gknd 8148 62 stored store VBN cord-010119-t1x9gknd 8148 63 for for IN cord-010119-t1x9gknd 8148 64 a a DT cord-010119-t1x9gknd 8148 65 week week NN cord-010119-t1x9gknd 8148 66 ( ( -LRB- cord-010119-t1x9gknd 8148 67 0.25 0.25 CD cord-010119-t1x9gknd 8148 68 % % NN cord-010119-t1x9gknd 8148 69 ) ) -RRB- cord-010119-t1x9gknd 8148 70 and and CC cord-010119-t1x9gknd 8148 71 longer long JJR cord-010119-t1x9gknd 8148 72 than than IN cord-010119-t1x9gknd 8148 73 a a DT cord-010119-t1x9gknd 8148 74 week week NN cord-010119-t1x9gknd 8148 75 ( ( -LRB- cord-010119-t1x9gknd 8148 76 0.35 0.35 CD cord-010119-t1x9gknd 8148 77 % % NN cord-010119-t1x9gknd 8148 78 ) ) -RRB- cord-010119-t1x9gknd 8149 1 ( ( -LRB- cord-010119-t1x9gknd 8149 2 p p NN cord-010119-t1x9gknd 8149 3 < < XX cord-010119-t1x9gknd 8149 4 0.05 0.05 CD cord-010119-t1x9gknd 8149 5 ) ) -RRB- cord-010119-t1x9gknd 8149 6 . . . cord-010119-t1x9gknd 8150 1 Conclusion conclusion NN cord-010119-t1x9gknd 8150 2 : : : cord-010119-t1x9gknd 8150 3 Irradiated irradiated JJ cord-010119-t1x9gknd 8150 4 RBCs rbc NNS cord-010119-t1x9gknd 8150 5 associated associate VBN cord-010119-t1x9gknd 8150 6 with with IN cord-010119-t1x9gknd 8150 7 a a DT cord-010119-t1x9gknd 8150 8 higher high JJR cord-010119-t1x9gknd 8150 9 incidence incidence NN cord-010119-t1x9gknd 8150 10 of of IN cord-010119-t1x9gknd 8150 11 transfusion transfusion NN cord-010119-t1x9gknd 8150 12 inflammation inflammation NN cord-010119-t1x9gknd 8150 13 AEs ae NNS cord-010119-t1x9gknd 8150 14 compared compare VBN cord-010119-t1x9gknd 8150 15 to to IN cord-010119-t1x9gknd 8150 16 non non JJ cord-010119-t1x9gknd 8150 17 - - JJ cord-010119-t1x9gknd 8150 18 irradiated irradiated JJ cord-010119-t1x9gknd 8150 19 RBCs rbc NNS cord-010119-t1x9gknd 8150 20 and and CC cord-010119-t1x9gknd 8151 1 this this DT cord-010119-t1x9gknd 8151 2 risk risk NN cord-010119-t1x9gknd 8151 3 increased increase VBD cord-010119-t1x9gknd 8151 4 when when WRB cord-010119-t1x9gknd 8151 5 RBCs rbc NNS cord-010119-t1x9gknd 8151 6 were be VBD cord-010119-t1x9gknd 8151 7 stored store VBN cord-010119-t1x9gknd 8151 8 longer long RBR cord-010119-t1x9gknd 8151 9 than than IN cord-010119-t1x9gknd 8151 10 1 1 CD cord-010119-t1x9gknd 8151 11 week week NN cord-010119-t1x9gknd 8151 12 after after IN cord-010119-t1x9gknd 8151 13 irradiation irradiation NN cord-010119-t1x9gknd 8151 14 . . . cord-010119-t1x9gknd 8152 1 While while IN cord-010119-t1x9gknd 8152 2 it -PRON- PRP cord-010119-t1x9gknd 8152 3 is be VBZ cord-010119-t1x9gknd 8152 4 likely likely RB cord-010119-t1x9gknd 8152 5 the the DT cord-010119-t1x9gknd 8152 6 patient patient JJ cord-010119-t1x9gknd 8152 7 population population NN cord-010119-t1x9gknd 8152 8 is be VBZ cord-010119-t1x9gknd 8152 9 a a DT cord-010119-t1x9gknd 8152 10 factor factor NN cord-010119-t1x9gknd 8152 11 in in IN cord-010119-t1x9gknd 8152 12 AE AE NNP cord-010119-t1x9gknd 8152 13 caused cause VBN cord-010119-t1x9gknd 8152 14 by by IN cord-010119-t1x9gknd 8152 15 irradiated irradiate VBN cord-010119-t1x9gknd 8152 16 RBCs rbc NNS cord-010119-t1x9gknd 8152 17 , , , cord-010119-t1x9gknd 8152 18 it -PRON- PRP cord-010119-t1x9gknd 8152 19 is be VBZ cord-010119-t1x9gknd 8152 20 also also RB cord-010119-t1x9gknd 8152 21 possible possible JJ cord-010119-t1x9gknd 8152 22 that that IN cord-010119-t1x9gknd 8152 23 RBC RBC NNP cord-010119-t1x9gknd 8152 24 radiation radiation NN cord-010119-t1x9gknd 8152 25 damage damage NN cord-010119-t1x9gknd 8152 26 , , , cord-010119-t1x9gknd 8152 27 as as IN cord-010119-t1x9gknd 8152 28 shown show VBN cord-010119-t1x9gknd 8152 29 in in IN cord-010119-t1x9gknd 8152 30 previous previous JJ cord-010119-t1x9gknd 8152 31 studies study NNS cord-010119-t1x9gknd 8152 32 , , , cord-010119-t1x9gknd 8152 33 contributed contribute VBD cord-010119-t1x9gknd 8152 34 to to IN cord-010119-t1x9gknd 8152 35 this this DT cord-010119-t1x9gknd 8152 36 increased increase VBN cord-010119-t1x9gknd 8152 37 AE AE NNP cord-010119-t1x9gknd 8152 38 incidence incidence NN cord-010119-t1x9gknd 8152 39 . . . cord-010119-t1x9gknd 8153 1 A a DT cord-010119-t1x9gknd 8153 2 list list NN cord-010119-t1x9gknd 8153 3 of of IN cord-010119-t1x9gknd 8153 4 patients patient NNS cord-010119-t1x9gknd 8153 5 with with IN cord-010119-t1x9gknd 8153 6 one one CD cord-010119-t1x9gknd 8153 7 of of IN cord-010119-t1x9gknd 8153 8 these these DT cord-010119-t1x9gknd 8153 9 icd10 icd10 NNS cord-010119-t1x9gknd 8153 10 codes code NNS cord-010119-t1x9gknd 8153 11 was be VBD cord-010119-t1x9gknd 8153 12 generated generate VBN cord-010119-t1x9gknd 8153 13 . . . cord-010119-t1x9gknd 8154 1 The the DT cord-010119-t1x9gknd 8154 2 EMR EMR NNP cord-010119-t1x9gknd 8154 3 was be VBD cord-010119-t1x9gknd 8154 4 searched search VBN cord-010119-t1x9gknd 8154 5 to to TO cord-010119-t1x9gknd 8154 6 find find VB cord-010119-t1x9gknd 8154 7 the the DT cord-010119-t1x9gknd 8154 8 clinical clinical JJ cord-010119-t1x9gknd 8154 9 scenario scenario NN cord-010119-t1x9gknd 8154 10 in in IN cord-010119-t1x9gknd 8154 11 which which WDT cord-010119-t1x9gknd 8154 12 TRALI TRALI NNP cord-010119-t1x9gknd 8154 13 was be VBD cord-010119-t1x9gknd 8154 14 mentioned mention VBN cord-010119-t1x9gknd 8154 15 . . . cord-010119-t1x9gknd 8155 1 These these DT cord-010119-t1x9gknd 8155 2 patients patient NNS cord-010119-t1x9gknd 8155 3 ' ' POS cord-010119-t1x9gknd 8155 4 records record NNS cord-010119-t1x9gknd 8155 5 were be VBD cord-010119-t1x9gknd 8155 6 then then RB cord-010119-t1x9gknd 8155 7 searched search VBN cord-010119-t1x9gknd 8155 8 within within IN cord-010119-t1x9gknd 8155 9 our -PRON- PRP$ cord-010119-t1x9gknd 8155 10 laboratory laboratory NN cord-010119-t1x9gknd 8155 11 information information NN cord-010119-t1x9gknd 8155 12 system system NN cord-010119-t1x9gknd 8155 13 ( ( -LRB- cord-010119-t1x9gknd 8155 14 CoPath CoPath NNP cord-010119-t1x9gknd 8155 15 ) ) -RRB- cord-010119-t1x9gknd 8155 16 , , , cord-010119-t1x9gknd 8155 17 to to TO cord-010119-t1x9gknd 8155 18 determine determine VB cord-010119-t1x9gknd 8155 19 if if IN cord-010119-t1x9gknd 8155 20 they -PRON- PRP cord-010119-t1x9gknd 8155 21 had have VBD cord-010119-t1x9gknd 8155 22 a a DT cord-010119-t1x9gknd 8155 23 transfusion transfusion NN cord-010119-t1x9gknd 8155 24 reaction reaction NN cord-010119-t1x9gknd 8155 25 reported report VBN cord-010119-t1x9gknd 8155 26 to to IN cord-010119-t1x9gknd 8155 27 our -PRON- PRP$ cord-010119-t1x9gknd 8155 28 transfusion transfusion NN cord-010119-t1x9gknd 8155 29 medicine medicine NN cord-010119-t1x9gknd 8155 30 service service NN cord-010119-t1x9gknd 8155 31 . . . cord-010119-t1x9gknd 8156 1 Results result NNS cord-010119-t1x9gknd 8157 1 /Finding /finde VBG cord-010119-t1x9gknd 8157 2 : : : cord-010119-t1x9gknd 8157 3 The the DT cord-010119-t1x9gknd 8157 4 search search NN cord-010119-t1x9gknd 8157 5 of of IN cord-010119-t1x9gknd 8157 6 our -PRON- PRP$ cord-010119-t1x9gknd 8157 7 electronic electronic JJ cord-010119-t1x9gknd 8157 8 medical medical JJ cord-010119-t1x9gknd 8157 9 record record NN cord-010119-t1x9gknd 8157 10 found find VBD cord-010119-t1x9gknd 8157 11 11 11 CD cord-010119-t1x9gknd 8157 12 patients patient NNS cord-010119-t1x9gknd 8157 13 from from IN cord-010119-t1x9gknd 8157 14 2011 2011 CD cord-010119-t1x9gknd 8157 15 - - SYM cord-010119-t1x9gknd 8157 16 2016 2016 CD cord-010119-t1x9gknd 8157 17 , , , cord-010119-t1x9gknd 8157 18 who who WP cord-010119-t1x9gknd 8157 19 had have VBD cord-010119-t1x9gknd 8157 20 TRALI TRALI NNP cord-010119-t1x9gknd 8157 21 mentioned mention VBN cord-010119-t1x9gknd 8157 22 in in IN cord-010119-t1x9gknd 8157 23 their -PRON- PRP$ cord-010119-t1x9gknd 8157 24 chart chart NN cord-010119-t1x9gknd 8157 25 as as IN cord-010119-t1x9gknd 8157 26 a a DT cord-010119-t1x9gknd 8157 27 diagnosis diagnosis NN cord-010119-t1x9gknd 8157 28 or or CC cord-010119-t1x9gknd 8157 29 possible possible JJ cord-010119-t1x9gknd 8157 30 / / SYM cord-010119-t1x9gknd 8157 31 likely likely JJ cord-010119-t1x9gknd 8157 32 diagnosis diagnosis NN cord-010119-t1x9gknd 8157 33 . . . cord-010119-t1x9gknd 8158 1 One one CD cord-010119-t1x9gknd 8158 2 patient patient NN cord-010119-t1x9gknd 8158 3 was be VBD cord-010119-t1x9gknd 8158 4 excluded exclude VBN cord-010119-t1x9gknd 8158 5 from from IN cord-010119-t1x9gknd 8158 6 our -PRON- PRP$ cord-010119-t1x9gknd 8158 7 study study NN cord-010119-t1x9gknd 8158 8 because because IN cord-010119-t1x9gknd 8158 9 TRALI TRALI NNP cord-010119-t1x9gknd 8158 10 was be VBD cord-010119-t1x9gknd 8158 11 mentioned mention VBN cord-010119-t1x9gknd 8158 12 as as IN cord-010119-t1x9gknd 8158 13 a a DT cord-010119-t1x9gknd 8158 14 past past JJ cord-010119-t1x9gknd 8158 15 medical medical JJ cord-010119-t1x9gknd 8158 16 history history NN cord-010119-t1x9gknd 8158 17 from from IN cord-010119-t1x9gknd 8158 18 an an DT cord-010119-t1x9gknd 8158 19 outside outside JJ cord-010119-t1x9gknd 8158 20 hospital hospital NN cord-010119-t1x9gknd 8158 21 . . . cord-010119-t1x9gknd 8159 1 Only only RB cord-010119-t1x9gknd 8159 2 the the DT cord-010119-t1x9gknd 8159 3 patients patient NNS cord-010119-t1x9gknd 8159 4 who who WP cord-010119-t1x9gknd 8159 5 had have VBD cord-010119-t1x9gknd 8159 6 TRALI TRALI NNP cord-010119-t1x9gknd 8159 7 listed list VBN cord-010119-t1x9gknd 8159 8 as as IN cord-010119-t1x9gknd 8159 9 a a DT cord-010119-t1x9gknd 8159 10 diagnosis diagnosis NN cord-010119-t1x9gknd 8159 11 or or CC cord-010119-t1x9gknd 8159 12 possible possible JJ cord-010119-t1x9gknd 8159 13 diagnosis diagnosis NN cord-010119-t1x9gknd 8159 14 were be VBD cord-010119-t1x9gknd 8159 15 included include VBN cord-010119-t1x9gknd 8159 16 in in IN cord-010119-t1x9gknd 8159 17 this this DT cord-010119-t1x9gknd 8159 18 study study NN cord-010119-t1x9gknd 8159 19 . . . cord-010119-t1x9gknd 8160 1 These these DT cord-010119-t1x9gknd 8160 2 10 10 CD cord-010119-t1x9gknd 8160 3 patients patient NNS cord-010119-t1x9gknd 8160 4 had have VBD cord-010119-t1x9gknd 8160 5 clinical clinical JJ cord-010119-t1x9gknd 8160 6 scenarios scenario NNS cord-010119-t1x9gknd 8160 7 in in IN cord-010119-t1x9gknd 8160 8 which which WDT cord-010119-t1x9gknd 8160 9 a a DT cord-010119-t1x9gknd 8160 10 transfusion transfusion NN cord-010119-t1x9gknd 8160 11 of of IN cord-010119-t1x9gknd 8160 12 a a DT cord-010119-t1x9gknd 8160 13 blood blood NN cord-010119-t1x9gknd 8160 14 product product NN cord-010119-t1x9gknd 8160 15 occurred occur VBD cord-010119-t1x9gknd 8160 16 which which WDT cord-010119-t1x9gknd 8160 17 was be VBD cord-010119-t1x9gknd 8160 18 followed follow VBN cord-010119-t1x9gknd 8160 19 by by IN cord-010119-t1x9gknd 8160 20 various various JJ cord-010119-t1x9gknd 8160 21 forms form NNS cord-010119-t1x9gknd 8160 22 of of IN cord-010119-t1x9gknd 8160 23 respiratory respiratory JJ cord-010119-t1x9gknd 8160 24 distress distress NN cord-010119-t1x9gknd 8160 25 . . . cord-010119-t1x9gknd 8161 1 The the DT cord-010119-t1x9gknd 8161 2 clinical clinical JJ cord-010119-t1x9gknd 8161 3 teams team NNS cord-010119-t1x9gknd 8161 4 caring care VBG cord-010119-t1x9gknd 8161 5 for for IN cord-010119-t1x9gknd 8161 6 these these DT cord-010119-t1x9gknd 8161 7 patients patient NNS cord-010119-t1x9gknd 8161 8 were be VBD cord-010119-t1x9gknd 8161 9 either either CC cord-010119-t1x9gknd 8161 10 giving give VBG cord-010119-t1x9gknd 8161 11 a a DT cord-010119-t1x9gknd 8161 12 diagnosis diagnosis NN cord-010119-t1x9gknd 8161 13 of of IN cord-010119-t1x9gknd 8161 14 TRALI TRALI NNP cord-010119-t1x9gknd 8161 15 or or CC cord-010119-t1x9gknd 8161 16 considering consider VBG cord-010119-t1x9gknd 8161 17 TRALI TRALI NNP cord-010119-t1x9gknd 8161 18 as as IN cord-010119-t1x9gknd 8161 19 a a DT cord-010119-t1x9gknd 8161 20 possible possible JJ cord-010119-t1x9gknd 8161 21 diagnosis diagnosis NN cord-010119-t1x9gknd 8161 22 . . . cord-010119-t1x9gknd 8162 1 Of of IN cord-010119-t1x9gknd 8162 2 these these DT cord-010119-t1x9gknd 8162 3 10 10 CD cord-010119-t1x9gknd 8162 4 cases case NNS cord-010119-t1x9gknd 8162 5 , , , cord-010119-t1x9gknd 8162 6 only only RB cord-010119-t1x9gknd 8162 7 2 2 CD cord-010119-t1x9gknd 8162 8 of of IN cord-010119-t1x9gknd 8162 9 them -PRON- PRP cord-010119-t1x9gknd 8162 10 were be VBD cord-010119-t1x9gknd 8162 11 reported report VBN cord-010119-t1x9gknd 8162 12 to to IN cord-010119-t1x9gknd 8162 13 our -PRON- PRP$ cord-010119-t1x9gknd 8162 14 transfusion transfusion NN cord-010119-t1x9gknd 8162 15 medicine medicine NN cord-010119-t1x9gknd 8162 16 service service NN cord-010119-t1x9gknd 8162 17 as as IN cord-010119-t1x9gknd 8162 18 transfusion transfusion NN cord-010119-t1x9gknd 8162 19 reactions reaction NNS cord-010119-t1x9gknd 8162 20 . . . cord-010119-t1x9gknd 8163 1 Of of IN cord-010119-t1x9gknd 8163 2 the the DT cord-010119-t1x9gknd 8163 3 reported report VBN cord-010119-t1x9gknd 8163 4 cases case NNS cord-010119-t1x9gknd 8163 5 , , , cord-010119-t1x9gknd 8163 6 one one CD cord-010119-t1x9gknd 8163 7 was be VBD cord-010119-t1x9gknd 8163 8 determined determine VBN cord-010119-t1x9gknd 8163 9 to to TO cord-010119-t1x9gknd 8163 10 be be VB cord-010119-t1x9gknd 8163 11 TRALI TRALI NNP cord-010119-t1x9gknd 8163 12 and and CC cord-010119-t1x9gknd 8163 13 the the DT cord-010119-t1x9gknd 8163 14 other other JJ cord-010119-t1x9gknd 8163 15 one one NN cord-010119-t1x9gknd 8163 16 was be VBD cord-010119-t1x9gknd 8163 17 consistent consistent JJ cord-010119-t1x9gknd 8163 18 with with IN cord-010119-t1x9gknd 8163 19 TACO TACO NNP cord-010119-t1x9gknd 8163 20 . . . cord-010119-t1x9gknd 8164 1 Eight eight CD cord-010119-t1x9gknd 8164 2 out out IN cord-010119-t1x9gknd 8164 3 of of IN cord-010119-t1x9gknd 8164 4 those those DT cord-010119-t1x9gknd 8164 5 10 10 CD cord-010119-t1x9gknd 8164 6 cases case NNS cord-010119-t1x9gknd 8164 7 were be VBD cord-010119-t1x9gknd 8164 8 never never RB cord-010119-t1x9gknd 8164 9 reported report VBN cord-010119-t1x9gknd 8164 10 . . . cord-010119-t1x9gknd 8165 1 Background Background NNP cord-010119-t1x9gknd 8165 2 / / SYM cord-010119-t1x9gknd 8165 3 Case Case NNP cord-010119-t1x9gknd 8165 4 Studies Studies NNPS cord-010119-t1x9gknd 8165 5 : : : cord-010119-t1x9gknd 8166 1 Despite despite IN cord-010119-t1x9gknd 8166 2 diligent diligent JJ cord-010119-t1x9gknd 8166 3 efforts effort NNS cord-010119-t1x9gknd 8166 4 to to TO cord-010119-t1x9gknd 8166 5 transfuse transfuse VB cord-010119-t1x9gknd 8166 6 the the DT cord-010119-t1x9gknd 8166 7 safest safe JJS cord-010119-t1x9gknd 8166 8 product product NN cord-010119-t1x9gknd 8166 9 available available JJ cord-010119-t1x9gknd 8166 10 to to IN cord-010119-t1x9gknd 8166 11 patients patient NNS cord-010119-t1x9gknd 8166 12 , , , cord-010119-t1x9gknd 8166 13 undetected undetected JJ cord-010119-t1x9gknd 8166 14 alloantibodies alloantibody NNS cord-010119-t1x9gknd 8166 15 may may MD cord-010119-t1x9gknd 8166 16 cause cause VB cord-010119-t1x9gknd 8166 17 delayed delay VBN cord-010119-t1x9gknd 8166 18 hemolytic hemolytic JJ cord-010119-t1x9gknd 8166 19 transfusion transfusion NN cord-010119-t1x9gknd 8166 20 reactions reaction NNS cord-010119-t1x9gknd 8166 21 ( ( -LRB- cord-010119-t1x9gknd 8166 22 DHTR DHTR NNP cord-010119-t1x9gknd 8166 23 ) ) -RRB- cord-010119-t1x9gknd 8166 24 . . . cord-010119-t1x9gknd 8167 1 This this DT cord-010119-t1x9gknd 8167 2 transfusion transfusion NN cord-010119-t1x9gknd 8167 3 reaction reaction NN cord-010119-t1x9gknd 8167 4 is be VBZ cord-010119-t1x9gknd 8167 5 seen see VBN cord-010119-t1x9gknd 8167 6 in in IN cord-010119-t1x9gknd 8167 7 as as RB cord-010119-t1x9gknd 8167 8 many many JJ cord-010119-t1x9gknd 8167 9 as as IN cord-010119-t1x9gknd 8167 10 1 1 CD cord-010119-t1x9gknd 8167 11 out out IN cord-010119-t1x9gknd 8167 12 of of IN cord-010119-t1x9gknd 8167 13 100 100 CD cord-010119-t1x9gknd 8167 14 transfused transfuse VBN cord-010119-t1x9gknd 8167 15 products product NNS cord-010119-t1x9gknd 8167 16 . . . cord-010119-t1x9gknd 8168 1 Therapeutic therapeutic JJ cord-010119-t1x9gknd 8168 2 plasma plasma NN cord-010119-t1x9gknd 8168 3 exchange exchange NN cord-010119-t1x9gknd 8168 4 ( ( -LRB- cord-010119-t1x9gknd 8168 5 TPE TPE NNP cord-010119-t1x9gknd 8168 6 ) ) -RRB- cord-010119-t1x9gknd 8168 7 may may MD cord-010119-t1x9gknd 8168 8 be be VB cord-010119-t1x9gknd 8168 9 employed employ VBN cord-010119-t1x9gknd 8168 10 to to TO cord-010119-t1x9gknd 8168 11 mitigate mitigate VB cord-010119-t1x9gknd 8168 12 ongoing ongoing JJ cord-010119-t1x9gknd 8168 13 immune immune JJ cord-010119-t1x9gknd 8168 14 mediated mediate VBN cord-010119-t1x9gknd 8168 15 hemolysis hemolysis NN cord-010119-t1x9gknd 8168 16 , , , cord-010119-t1x9gknd 8168 17 but but CC cord-010119-t1x9gknd 8168 18 few few JJ cord-010119-t1x9gknd 8168 19 reports report NNS cord-010119-t1x9gknd 8168 20 in in IN cord-010119-t1x9gknd 8168 21 the the DT cord-010119-t1x9gknd 8168 22 literature literature NN cord-010119-t1x9gknd 8168 23 describe describe VBP cord-010119-t1x9gknd 8168 24 TPE TPE NNP cord-010119-t1x9gknd 8168 25 for for IN cord-010119-t1x9gknd 8168 26 clinical clinical JJ cord-010119-t1x9gknd 8168 27 management management NN cord-010119-t1x9gknd 8168 28 after after IN cord-010119-t1x9gknd 8168 29 profound profound JJ cord-010119-t1x9gknd 8168 30 hemolysis hemolysis NN cord-010119-t1x9gknd 8168 31 . . . cord-010119-t1x9gknd 8169 1 Study Study NNP cord-010119-t1x9gknd 8169 2 Design Design NNP cord-010119-t1x9gknd 8169 3 / / SYM cord-010119-t1x9gknd 8169 4 Method method NN cord-010119-t1x9gknd 8169 5 : : : cord-010119-t1x9gknd 8170 1 Case case NN cord-010119-t1x9gknd 8170 2 review review NN cord-010119-t1x9gknd 8170 3 of of IN cord-010119-t1x9gknd 8170 4 a a DT cord-010119-t1x9gknd 8170 5 patient patient NN cord-010119-t1x9gknd 8170 6 was be VBD cord-010119-t1x9gknd 8170 7 performed perform VBN cord-010119-t1x9gknd 8170 8 after after IN cord-010119-t1x9gknd 8170 9 diagnosis diagnosis NN cord-010119-t1x9gknd 8170 10 and and CC cord-010119-t1x9gknd 8170 11 treatment treatment NN cord-010119-t1x9gknd 8170 12 of of IN cord-010119-t1x9gknd 8170 13 severe severe JJ cord-010119-t1x9gknd 8170 14 DHTR DHTR NNP cord-010119-t1x9gknd 8170 15 . . . cord-010119-t1x9gknd 8171 1 Results/ Results/ . cord-010119-t1x9gknd 8172 1 Finding finding NN cord-010119-t1x9gknd 8172 2 : : : cord-010119-t1x9gknd 8173 1 A a DT cord-010119-t1x9gknd 8173 2 man man NN cord-010119-t1x9gknd 8173 3 with with IN cord-010119-t1x9gknd 8173 4 a a DT cord-010119-t1x9gknd 8173 5 history history NN cord-010119-t1x9gknd 8173 6 of of IN cord-010119-t1x9gknd 8173 7 gastrointestinal gastrointestinal JJ cord-010119-t1x9gknd 8173 8 bleeding bleeding NN cord-010119-t1x9gknd 8173 9 presented present VBN cord-010119-t1x9gknd 8173 10 to to IN cord-010119-t1x9gknd 8173 11 the the DT cord-010119-t1x9gknd 8173 12 emergency emergency NN cord-010119-t1x9gknd 8173 13 room room NN cord-010119-t1x9gknd 8173 14 with with IN cord-010119-t1x9gknd 8173 15 shortness shortness NN cord-010119-t1x9gknd 8173 16 of of IN cord-010119-t1x9gknd 8173 17 breath breath NN cord-010119-t1x9gknd 8173 18 and and CC cord-010119-t1x9gknd 8173 19 " " `` cord-010119-t1x9gknd 8173 20 hematuria hematuria NN cord-010119-t1x9gknd 8173 21 " " '' cord-010119-t1x9gknd 8173 22 . . . cord-010119-t1x9gknd 8174 1 He -PRON- PRP cord-010119-t1x9gknd 8174 2 had have VBD cord-010119-t1x9gknd 8174 3 a a DT cord-010119-t1x9gknd 8174 4 known know VBN cord-010119-t1x9gknd 8174 5 history history NN cord-010119-t1x9gknd 8174 6 of of IN cord-010119-t1x9gknd 8174 7 anti anti JJ cord-010119-t1x9gknd 8174 8 - - JJ cord-010119-t1x9gknd 8174 9 D d JJ cord-010119-t1x9gknd 8174 10 and and CC cord-010119-t1x9gknd 8174 11 anti anti JJ cord-010119-t1x9gknd 8174 12 - - NN cord-010119-t1x9gknd 8174 13 C C NNP cord-010119-t1x9gknd 8174 14 , , , cord-010119-t1x9gknd 8174 15 and and CC cord-010119-t1x9gknd 8174 16 was be VBD cord-010119-t1x9gknd 8174 17 transfused transfuse VBN cord-010119-t1x9gknd 8174 18 two two CD cord-010119-t1x9gknd 8174 19 units unit NNS cord-010119-t1x9gknd 8174 20 of of IN cord-010119-t1x9gknd 8174 21 crossmatch crossmatch NN cord-010119-t1x9gknd 8174 22 compatible compatible JJ cord-010119-t1x9gknd 8174 23 RBCs rbc NNS cord-010119-t1x9gknd 8174 24 seven seven CD cord-010119-t1x9gknd 8174 25 days day NNS cord-010119-t1x9gknd 8174 26 prior prior RB cord-010119-t1x9gknd 8174 27 during during IN cord-010119-t1x9gknd 8174 28 a a DT cord-010119-t1x9gknd 8174 29 previous previous JJ cord-010119-t1x9gknd 8174 30 admission admission NN cord-010119-t1x9gknd 8174 31 . . . cord-010119-t1x9gknd 8175 1 Readmission readmission NN cord-010119-t1x9gknd 8175 2 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8175 3 ( ( -LRB- cord-010119-t1x9gknd 8175 4 Hb Hb NNP cord-010119-t1x9gknd 8175 5 ) ) -RRB- cord-010119-t1x9gknd 8175 6 was be VBD cord-010119-t1x9gknd 8175 7 8.7 8.7 CD cord-010119-t1x9gknd 8175 8 g g NN cord-010119-t1x9gknd 8175 9 / / SYM cord-010119-t1x9gknd 8175 10 dL dl NN cord-010119-t1x9gknd 8175 11 but but CC cord-010119-t1x9gknd 8175 12 declined decline VBD cord-010119-t1x9gknd 8175 13 to to IN cord-010119-t1x9gknd 8175 14 7.3 7.3 CD cord-010119-t1x9gknd 8175 15 g g NN cord-010119-t1x9gknd 8175 16 / / SYM cord-010119-t1x9gknd 8175 17 dL dl NN cord-010119-t1x9gknd 8175 18 the the DT cord-010119-t1x9gknd 8175 19 next next JJ cord-010119-t1x9gknd 8175 20 day day NN cord-010119-t1x9gknd 8175 21 . . . cord-010119-t1x9gknd 8176 1 An an DT cord-010119-t1x9gknd 8176 2 antibody antibody NN cord-010119-t1x9gknd 8176 3 screen screen NN cord-010119-t1x9gknd 8176 4 was be VBD cord-010119-t1x9gknd 8176 5 consistent consistent JJ cord-010119-t1x9gknd 8176 6 with with IN cord-010119-t1x9gknd 8176 7 anti anti JJ cord-010119-t1x9gknd 8176 8 - - JJ cord-010119-t1x9gknd 8176 9 D d JJ cord-010119-t1x9gknd 8176 10 , , , cord-010119-t1x9gknd 8176 11 anti anti JJ cord-010119-t1x9gknd 8176 12 - - NNP cord-010119-t1x9gknd 8176 13 C C NNP cord-010119-t1x9gknd 8176 14 , , , cord-010119-t1x9gknd 8176 15 and and CC cord-010119-t1x9gknd 8176 16 direct direct JJ cord-010119-t1x9gknd 8176 17 antiglobulin antiglobulin NN cord-010119-t1x9gknd 8176 18 test test NN cord-010119-t1x9gknd 8176 19 ( ( -LRB- cord-010119-t1x9gknd 8176 20 DAT DAT NNP cord-010119-t1x9gknd 8176 21 ) ) -RRB- cord-010119-t1x9gknd 8176 22 was be VBD cord-010119-t1x9gknd 8176 23 negative negative JJ cord-010119-t1x9gknd 8176 24 . . . cord-010119-t1x9gknd 8177 1 He -PRON- PRP cord-010119-t1x9gknd 8177 2 received receive VBD cord-010119-t1x9gknd 8177 3 three three CD cord-010119-t1x9gknd 8177 4 units unit NNS cord-010119-t1x9gknd 8177 5 of of IN cord-010119-t1x9gknd 8177 6 crossmatch crossmatch NN cord-010119-t1x9gknd 8177 7 compatible compatible JJ cord-010119-t1x9gknd 8177 8 RBCs rbc NNS cord-010119-t1x9gknd 8177 9 over over IN cord-010119-t1x9gknd 8177 10 days day NNS cord-010119-t1x9gknd 8177 11 2 2 CD cord-010119-t1x9gknd 8177 12 and and CC cord-010119-t1x9gknd 8177 13 3 3 CD cord-010119-t1x9gknd 8177 14 with with IN cord-010119-t1x9gknd 8177 15 poor poor JJ cord-010119-t1x9gknd 8177 16 responses response NNS cord-010119-t1x9gknd 8177 17 . . . cord-010119-t1x9gknd 8178 1 On on IN cord-010119-t1x9gknd 8178 2 day day NN cord-010119-t1x9gknd 8178 3 4 4 CD cord-010119-t1x9gknd 8178 4 , , , cord-010119-t1x9gknd 8178 5 routine routine JJ cord-010119-t1x9gknd 8178 6 labs lab NNS cord-010119-t1x9gknd 8178 7 could could MD cord-010119-t1x9gknd 8178 8 not not RB cord-010119-t1x9gknd 8178 9 be be VB cord-010119-t1x9gknd 8178 10 reported report VBN cord-010119-t1x9gknd 8178 11 due due IN cord-010119-t1x9gknd 8178 12 to to IN cord-010119-t1x9gknd 8178 13 marked marked JJ cord-010119-t1x9gknd 8178 14 hemolysis hemolysis NN cord-010119-t1x9gknd 8178 15 , , , cord-010119-t1x9gknd 8178 16 he -PRON- PRP cord-010119-t1x9gknd 8178 17 had have VBD cord-010119-t1x9gknd 8178 18 " " `` cord-010119-t1x9gknd 8178 19 worsening worsen VBG cord-010119-t1x9gknd 8178 20 hematuria hematuria NN cord-010119-t1x9gknd 8178 21 " " '' cord-010119-t1x9gknd 8178 22 , , , cord-010119-t1x9gknd 8178 23 creatinine creatinine NN cord-010119-t1x9gknd 8178 24 rose rise VBD cord-010119-t1x9gknd 8178 25 from from IN cord-010119-t1x9gknd 8179 1 1.0 1.0 CD cord-010119-t1x9gknd 8179 2 mg mg NN cord-010119-t1x9gknd 8179 3 / / SYM cord-010119-t1x9gknd 8179 4 dL dl NN cord-010119-t1x9gknd 8179 5 to to IN cord-010119-t1x9gknd 8179 6 1.8 1.8 CD cord-010119-t1x9gknd 8179 7 mg mg NNP cord-010119-t1x9gknd 8179 8 / / SYM cord-010119-t1x9gknd 8179 9 dL dl NN cord-010119-t1x9gknd 8180 1 ( ( -LRB- cord-010119-t1x9gknd 8180 2 reference reference NN cord-010119-t1x9gknd 8180 3 0.8 0.8 CD cord-010119-t1x9gknd 8180 4 - - SYM cord-010119-t1x9gknd 8180 5 1.3 1.3 CD cord-010119-t1x9gknd 8180 6 mg mg NNP cord-010119-t1x9gknd 8180 7 / / SYM cord-010119-t1x9gknd 8180 8 dL dl NN cord-010119-t1x9gknd 8180 9 ) ) -RRB- cord-010119-t1x9gknd 8180 10 , , , cord-010119-t1x9gknd 8180 11 and and CC cord-010119-t1x9gknd 8181 1 lactate lactate NN cord-010119-t1x9gknd 8181 2 dehydrogenase dehydrogenase NN cord-010119-t1x9gknd 8181 3 was be VBD cord-010119-t1x9gknd 8181 4 above above IN cord-010119-t1x9gknd 8181 5 reportable reportable JJ cord-010119-t1x9gknd 8181 6 linearity linearity NN cord-010119-t1x9gknd 8181 7 , , , cord-010119-t1x9gknd 8181 8 > > XX cord-010119-t1x9gknd 8182 1 2500 2500 CD cord-010119-t1x9gknd 8182 2 u u NNP cord-010119-t1x9gknd 8182 3 / / SYM cord-010119-t1x9gknd 8182 4 L L NNP cord-010119-t1x9gknd 8182 5 ( ( -LRB- cord-010119-t1x9gknd 8182 6 reference reference NN cord-010119-t1x9gknd 8182 7 122 122 CD cord-010119-t1x9gknd 8182 8 - - SYM cord-010119-t1x9gknd 8182 9 222 222 CD cord-010119-t1x9gknd 8182 10 u u NNP cord-010119-t1x9gknd 8182 11 / / SYM cord-010119-t1x9gknd 8182 12 L L NNP cord-010119-t1x9gknd 8182 13 ) ) -RRB- cord-010119-t1x9gknd 8182 14 . . . cord-010119-t1x9gknd 8183 1 Testing testing NN cord-010119-t1x9gknd 8183 2 revealed reveal VBD cord-010119-t1x9gknd 8183 3 additional additional JJ cord-010119-t1x9gknd 8183 4 anti anti JJ cord-010119-t1x9gknd 8183 5 - - JJ cord-010119-t1x9gknd 8183 6 E e JJ cord-010119-t1x9gknd 8183 7 , , , cord-010119-t1x9gknd 8183 8 anti anti JJ cord-010119-t1x9gknd 8183 9 - - NNP cord-010119-t1x9gknd 8183 10 Jkb Jkb NNP cord-010119-t1x9gknd 8183 11 , , , cord-010119-t1x9gknd 8183 12 DAT DAT NNP cord-010119-t1x9gknd 8183 13 C31 C31 NNP cord-010119-t1x9gknd 8183 14 , , , cord-010119-t1x9gknd 8183 15 plasma plasma NN cord-010119-t1x9gknd 8183 16 free free JJ cord-010119-t1x9gknd 8183 17 Hb Hb NNP cord-010119-t1x9gknd 8183 18 64.4 64.4 CD cord-010119-t1x9gknd 8183 19 mg mg NNP cord-010119-t1x9gknd 8183 20 / / SYM cord-010119-t1x9gknd 8183 21 dL dl NN cord-010119-t1x9gknd 8184 1 ( ( -LRB- cord-010119-t1x9gknd 8184 2 reference reference NN cord-010119-t1x9gknd 8184 3 1 1 CD cord-010119-t1x9gknd 8185 1 -15.2 -15.2 : cord-010119-t1x9gknd 8185 2 mg mg NNP cord-010119-t1x9gknd 8185 3 / / SYM cord-010119-t1x9gknd 8185 4 dL dL NNP cord-010119-t1x9gknd 8185 5 ) ) -RRB- cord-010119-t1x9gknd 8185 6 , , , cord-010119-t1x9gknd 8185 7 and and CC cord-010119-t1x9gknd 8185 8 hemoglobinuria hemoglobinuria NNP cord-010119-t1x9gknd 8185 9 . . . cord-010119-t1x9gknd 8186 1 Four four CD cord-010119-t1x9gknd 8186 2 of of IN cord-010119-t1x9gknd 8186 3 five five CD cord-010119-t1x9gknd 8186 4 transfused transfuse VBN cord-010119-t1x9gknd 8186 5 RBC RBC NNP cord-010119-t1x9gknd 8186 6 units unit NNS cord-010119-t1x9gknd 8186 7 were be VBD cord-010119-t1x9gknd 8186 8 Jk(b1 Jk(b1 NNPS cord-010119-t1x9gknd 8186 9 ) ) -RRB- cord-010119-t1x9gknd 8186 10 , , , cord-010119-t1x9gknd 8186 11 one one CD cord-010119-t1x9gknd 8186 12 of of IN cord-010119-t1x9gknd 8186 13 which which WDT cord-010119-t1x9gknd 8186 14 was be VBD cord-010119-t1x9gknd 8186 15 also also RB cord-010119-t1x9gknd 8186 16 E1 e1 NN cord-010119-t1x9gknd 8186 17 . . . cord-010119-t1x9gknd 8187 1 One one CD cord-010119-t1x9gknd 8187 2 volume volume NN cord-010119-t1x9gknd 8187 3 TPE TPE NNP cord-010119-t1x9gknd 8187 4 was be VBD cord-010119-t1x9gknd 8187 5 performed perform VBN cord-010119-t1x9gknd 8187 6 to to TO cord-010119-t1x9gknd 8187 7 remove remove VB cord-010119-t1x9gknd 8187 8 free free JJ cord-010119-t1x9gknd 8187 9 Hb Hb NNP cord-010119-t1x9gknd 8187 10 on on IN cord-010119-t1x9gknd 8187 11 days day NNS cord-010119-t1x9gknd 8187 12 5 5 CD cord-010119-t1x9gknd 8187 13 , , , cord-010119-t1x9gknd 8187 14 6 6 CD cord-010119-t1x9gknd 8187 15 , , , cord-010119-t1x9gknd 8187 16 and and CC cord-010119-t1x9gknd 8187 17 7 7 CD cord-010119-t1x9gknd 8187 18 using use VBG cord-010119-t1x9gknd 8187 19 fresh fresh JJ cord-010119-t1x9gknd 8187 20 frozen frozen JJ cord-010119-t1x9gknd 8187 21 plasma plasma NN cord-010119-t1x9gknd 8187 22 as as IN cord-010119-t1x9gknd 8187 23 replacement replacement NN cord-010119-t1x9gknd 8187 24 fluid fluid NN cord-010119-t1x9gknd 8187 25 for for IN cord-010119-t1x9gknd 8187 26 haptoglobin haptoglobin NN cord-010119-t1x9gknd 8187 27 supplementation supplementation NN cord-010119-t1x9gknd 8187 28 . . . cord-010119-t1x9gknd 8188 1 Creatinine creatinine NN cord-010119-t1x9gknd 8188 2 peaked peak VBD cord-010119-t1x9gknd 8188 3 at at IN cord-010119-t1x9gknd 8188 4 3.7 3.7 CD cord-010119-t1x9gknd 8188 5 mg mg NNP cord-010119-t1x9gknd 8188 6 / / SYM cord-010119-t1x9gknd 8188 7 dL dl NN cord-010119-t1x9gknd 8188 8 on on IN cord-010119-t1x9gknd 8188 9 day day NN cord-010119-t1x9gknd 8188 10 13 13 CD cord-010119-t1x9gknd 8188 11 , , , cord-010119-t1x9gknd 8188 12 decreased decrease VBD cord-010119-t1x9gknd 8188 13 to to IN cord-010119-t1x9gknd 8188 14 2.3 2.3 CD cord-010119-t1x9gknd 8188 15 mg mg NNP cord-010119-t1x9gknd 8188 16 / / SYM cord-010119-t1x9gknd 8188 17 dL dl NN cord-010119-t1x9gknd 8188 18 before before IN cord-010119-t1x9gknd 8188 19 discharge discharge NN cord-010119-t1x9gknd 8188 20 on on IN cord-010119-t1x9gknd 8188 21 day day NN cord-010119-t1x9gknd 8189 1 Results result NNS cord-010119-t1x9gknd 8189 2 / / SYM cord-010119-t1x9gknd 8189 3 Findings finding NNS cord-010119-t1x9gknd 8189 4 : : : cord-010119-t1x9gknd 8190 1 Twenty twenty CD cord-010119-t1x9gknd 8190 2 three three CD cord-010119-t1x9gknd 8190 3 cases case NNS cord-010119-t1x9gknd 8190 4 were be VBD cord-010119-t1x9gknd 8190 5 identified identify VBN cord-010119-t1x9gknd 8190 6 , , , cord-010119-t1x9gknd 8190 7 of of IN cord-010119-t1x9gknd 8190 8 which which WDT cord-010119-t1x9gknd 8190 9 20 20 CD cord-010119-t1x9gknd 8190 10 had have VBD cord-010119-t1x9gknd 8190 11 medical medical JJ cord-010119-t1x9gknd 8190 12 records record NNS cord-010119-t1x9gknd 8190 13 available available JJ cord-010119-t1x9gknd 8190 14 for for IN cord-010119-t1x9gknd 8190 15 analysis analysis NN cord-010119-t1x9gknd 8190 16 . . . cord-010119-t1x9gknd 8191 1 Ten ten CD cord-010119-t1x9gknd 8191 2 ( ( -LRB- cord-010119-t1x9gknd 8191 3 50 50 CD cord-010119-t1x9gknd 8191 4 % % NN cord-010119-t1x9gknd 8191 5 ) ) -RRB- cord-010119-t1x9gknd 8191 6 patients patient NNS cord-010119-t1x9gknd 8191 7 were be VBD cord-010119-t1x9gknd 8191 8 male male JJ cord-010119-t1x9gknd 8191 9 , , , cord-010119-t1x9gknd 8191 10 the the DT cord-010119-t1x9gknd 8191 11 mean mean JJ cord-010119-t1x9gknd 8191 12 age age NN cord-010119-t1x9gknd 8191 13 was be VBD cord-010119-t1x9gknd 8191 14 50.4 50.4 CD cord-010119-t1x9gknd 8191 15 years year NNS cord-010119-t1x9gknd 8192 1 ( ( -LRB- cord-010119-t1x9gknd 8192 2 range range VBP cord-010119-t1x9gknd 8192 3 24 24 CD cord-010119-t1x9gknd 8192 4 - - SYM cord-010119-t1x9gknd 8192 5 76 76 CD cord-010119-t1x9gknd 8192 6 years year NNS cord-010119-t1x9gknd 8192 7 ) ) -RRB- cord-010119-t1x9gknd 8192 8 , , , cord-010119-t1x9gknd 8192 9 15 15 CD cord-010119-t1x9gknd 8192 10 ( ( -LRB- cord-010119-t1x9gknd 8192 11 75 75 CD cord-010119-t1x9gknd 8192 12 % % NN cord-010119-t1x9gknd 8192 13 ) ) -RRB- cord-010119-t1x9gknd 8192 14 had have VBD cord-010119-t1x9gknd 8192 15 an an DT cord-010119-t1x9gknd 8192 16 underlying underlying JJ cord-010119-t1x9gknd 8192 17 hematologic hematologic JJ cord-010119-t1x9gknd 8192 18 malignancy malignancy NN cord-010119-t1x9gknd 8192 19 or or CC cord-010119-t1x9gknd 8192 20 bone bone NN cord-010119-t1x9gknd 8192 21 marrow marrow NN cord-010119-t1x9gknd 8192 22 disorder disorder NN cord-010119-t1x9gknd 8192 23 , , , cord-010119-t1x9gknd 8192 24 and and CC cord-010119-t1x9gknd 8192 25 3 3 CD cord-010119-t1x9gknd 8192 26 ( ( -LRB- cord-010119-t1x9gknd 8192 27 15 15 CD cord-010119-t1x9gknd 8192 28 % % NN cord-010119-t1x9gknd 8192 29 ) ) -RRB- cord-010119-t1x9gknd 8192 30 had have VBD cord-010119-t1x9gknd 8192 31 a a DT cord-010119-t1x9gknd 8192 32 history history NN cord-010119-t1x9gknd 8192 33 of of IN cord-010119-t1x9gknd 8192 34 coronary coronary JJ cord-010119-t1x9gknd 8192 35 artery artery NN cord-010119-t1x9gknd 8192 36 disease disease NN cord-010119-t1x9gknd 8192 37 ( ( -LRB- cord-010119-t1x9gknd 8192 38 CAD CAD NNP cord-010119-t1x9gknd 8192 39 ) ) -RRB- cord-010119-t1x9gknd 8192 40 . . . cord-010119-t1x9gknd 8193 1 The the DT cord-010119-t1x9gknd 8193 2 implicated implicated JJ cord-010119-t1x9gknd 8193 3 units unit NNS cord-010119-t1x9gknd 8193 4 included include VBD cord-010119-t1x9gknd 8193 5 14 14 CD cord-010119-t1x9gknd 8193 6 ( ( -LRB- cord-010119-t1x9gknd 8193 7 70 70 CD cord-010119-t1x9gknd 8193 8 % % NN cord-010119-t1x9gknd 8193 9 ) ) -RRB- cord-010119-t1x9gknd 8193 10 red red JJ cord-010119-t1x9gknd 8193 11 blood blood NN cord-010119-t1x9gknd 8193 12 cells cell NNS cord-010119-t1x9gknd 8193 13 and and CC cord-010119-t1x9gknd 8193 14 6 6 CD cord-010119-t1x9gknd 8193 15 ( ( -LRB- cord-010119-t1x9gknd 8193 16 30 30 CD cord-010119-t1x9gknd 8193 17 % % NN cord-010119-t1x9gknd 8193 18 ) ) -RRB- cord-010119-t1x9gknd 8193 19 platelets platelet NNS cord-010119-t1x9gknd 8193 20 ; ; : cord-010119-t1x9gknd 8193 21 17 17 CD cord-010119-t1x9gknd 8193 22 ( ( -LRB- cord-010119-t1x9gknd 8193 23 85 85 CD cord-010119-t1x9gknd 8193 24 % % NN cord-010119-t1x9gknd 8193 25 ) ) -RRB- cord-010119-t1x9gknd 8193 26 patients patient NNS cord-010119-t1x9gknd 8193 27 received receive VBD cord-010119-t1x9gknd 8193 28 a a DT cord-010119-t1x9gknd 8193 29 single single JJ cord-010119-t1x9gknd 8193 30 unit unit NN cord-010119-t1x9gknd 8193 31 , , , cord-010119-t1x9gknd 8193 32 and and CC cord-010119-t1x9gknd 8193 33 3 3 CD cord-010119-t1x9gknd 8193 34 ( ( -LRB- cord-010119-t1x9gknd 8193 35 15 15 CD cord-010119-t1x9gknd 8193 36 % % NN cord-010119-t1x9gknd 8193 37 ) ) -RRB- cord-010119-t1x9gknd 8193 38 received receive VBD cord-010119-t1x9gknd 8193 39 two two CD cord-010119-t1x9gknd 8193 40 or or CC cord-010119-t1x9gknd 8193 41 more more JJR cord-010119-t1x9gknd 8193 42 within within IN cord-010119-t1x9gknd 8193 43 the the DT cord-010119-t1x9gknd 8193 44 previous previous JJ cord-010119-t1x9gknd 8193 45 6 6 CD cord-010119-t1x9gknd 8193 46 hours hour NNS cord-010119-t1x9gknd 8193 47 ; ; : cord-010119-t1x9gknd 8193 48 the the DT cord-010119-t1x9gknd 8193 49 mean mean JJ cord-010119-t1x9gknd 8193 50 volume volume NN cord-010119-t1x9gknd 8193 51 transfused transfuse VBN cord-010119-t1x9gknd 8193 52 was be VBD cord-010119-t1x9gknd 8193 53 153.3 153.3 CD cord-010119-t1x9gknd 8193 54 mL ml XX cord-010119-t1x9gknd 8193 55 ( ( -LRB- cord-010119-t1x9gknd 8193 56 range range NN cord-010119-t1x9gknd 8193 57 20 20 CD cord-010119-t1x9gknd 8193 58 - - SYM cord-010119-t1x9gknd 8193 59 280 280 CD cord-010119-t1x9gknd 8193 60 ml ml NNS cord-010119-t1x9gknd 8193 61 ) ) -RRB- cord-010119-t1x9gknd 8193 62 . . . cord-010119-t1x9gknd 8194 1 The the DT cord-010119-t1x9gknd 8194 2 mean mean JJ cord-010119-t1x9gknd 8194 3 time time NN cord-010119-t1x9gknd 8194 4 to to IN cord-010119-t1x9gknd 8194 5 onset onset NN cord-010119-t1x9gknd 8194 6 of of IN cord-010119-t1x9gknd 8194 7 chest chest NN cord-010119-t1x9gknd 8194 8 pain pain NN cord-010119-t1x9gknd 8194 9 was be VBD cord-010119-t1x9gknd 8194 10 92.15 92.15 CD cord-010119-t1x9gknd 8194 11 minutes minute NNS cord-010119-t1x9gknd 8194 12 ( ( -LRB- cord-010119-t1x9gknd 8194 13 SD SD NNP cord-010119-t1x9gknd 8194 14 85 85 CD cord-010119-t1x9gknd 8194 15 minutes minute NNS cord-010119-t1x9gknd 8194 16 ) ) -RRB- cord-010119-t1x9gknd 8194 17 , , , cord-010119-t1x9gknd 8194 18 with with IN cord-010119-t1x9gknd 8194 19 90 90 CD cord-010119-t1x9gknd 8194 20 % % NN cord-010119-t1x9gknd 8194 21 of of IN cord-010119-t1x9gknd 8194 22 patients patient NNS cord-010119-t1x9gknd 8194 23 presenting present VBG cord-010119-t1x9gknd 8194 24 within within IN cord-010119-t1x9gknd 8194 25 2.5 2.5 CD cord-010119-t1x9gknd 8194 26 hours hour NNS cord-010119-t1x9gknd 8194 27 and and CC cord-010119-t1x9gknd 8194 28 100 100 CD cord-010119-t1x9gknd 8194 29 % % NN cord-010119-t1x9gknd 8194 30 within within IN cord-010119-t1x9gknd 8194 31 6 6 CD cord-010119-t1x9gknd 8194 32 hours hour NNS cord-010119-t1x9gknd 8194 33 of of IN cord-010119-t1x9gknd 8194 34 starting start VBG cord-010119-t1x9gknd 8194 35 the the DT cord-010119-t1x9gknd 8194 36 transfusion transfusion NN cord-010119-t1x9gknd 8194 37 . . . cord-010119-t1x9gknd 8195 1 Chest chest NN cord-010119-t1x9gknd 8195 2 pain pain NN cord-010119-t1x9gknd 8195 3 was be VBD cord-010119-t1x9gknd 8195 4 present present JJ cord-010119-t1x9gknd 8195 5 as as IN cord-010119-t1x9gknd 8195 6 the the DT cord-010119-t1x9gknd 8195 7 only only JJ cord-010119-t1x9gknd 8195 8 symptom symptom NN cord-010119-t1x9gknd 8195 9 in in IN cord-010119-t1x9gknd 8195 10 35 35 CD cord-010119-t1x9gknd 8195 11 % % NN cord-010119-t1x9gknd 8195 12 of of IN cord-010119-t1x9gknd 8195 13 the the DT cord-010119-t1x9gknd 8195 14 cases case NNS cord-010119-t1x9gknd 8195 15 , , , cord-010119-t1x9gknd 8195 16 and and CC cord-010119-t1x9gknd 8195 17 for for IN cord-010119-t1x9gknd 8195 18 the the DT cord-010119-t1x9gknd 8195 19 other other JJ cord-010119-t1x9gknd 8195 20 cases case NNS cord-010119-t1x9gknd 8195 21 the the DT cord-010119-t1x9gknd 8195 22 accompanying accompany VBG cord-010119-t1x9gknd 8195 23 symptoms symptom NNS cord-010119-t1x9gknd 8195 24 included include VBD cord-010119-t1x9gknd 8195 25 dyspnea dyspnea NN cord-010119-t1x9gknd 8195 26 ( ( -LRB- cord-010119-t1x9gknd 8195 27 30 30 CD cord-010119-t1x9gknd 8195 28 % % NN cord-010119-t1x9gknd 8195 29 ) ) -RRB- cord-010119-t1x9gknd 8195 30 , , , cord-010119-t1x9gknd 8195 31 fever fever NN cord-010119-t1x9gknd 8195 32 ( ( -LRB- cord-010119-t1x9gknd 8195 33 25 25 CD cord-010119-t1x9gknd 8195 34 % % NN cord-010119-t1x9gknd 8195 35 ) ) -RRB- cord-010119-t1x9gknd 8195 36 , , , cord-010119-t1x9gknd 8195 37 back back JJ cord-010119-t1x9gknd 8195 38 pain pain NN cord-010119-t1x9gknd 8195 39 ( ( -LRB- cord-010119-t1x9gknd 8195 40 20 20 CD cord-010119-t1x9gknd 8195 41 % % NN cord-010119-t1x9gknd 8195 42 ) ) -RRB- cord-010119-t1x9gknd 8195 43 , , , cord-010119-t1x9gknd 8195 44 and and CC cord-010119-t1x9gknd 8195 45 hypo hypo NN cord-010119-t1x9gknd 8195 46 - - HYPH cord-010119-t1x9gknd 8195 47 and and CC cord-010119-t1x9gknd 8195 48 hypertension hypertension NN cord-010119-t1x9gknd 8195 49 ( ( -LRB- cord-010119-t1x9gknd 8195 50 10 10 CD cord-010119-t1x9gknd 8195 51 % % NN cord-010119-t1x9gknd 8195 52 ) ) -RRB- cord-010119-t1x9gknd 8195 53 . . . cord-010119-t1x9gknd 8196 1 A a DT cord-010119-t1x9gknd 8196 2 post post JJ cord-010119-t1x9gknd 8196 3 - - JJ cord-010119-t1x9gknd 8196 4 transfusion transfusion JJ cord-010119-t1x9gknd 8196 5 chest chest NN cord-010119-t1x9gknd 8196 6 X x NN cord-010119-t1x9gknd 8196 7 - - NN cord-010119-t1x9gknd 8196 8 ray ray NN cord-010119-t1x9gknd 8196 9 was be VBD cord-010119-t1x9gknd 8196 10 performed perform VBN cord-010119-t1x9gknd 8196 11 in in IN cord-010119-t1x9gknd 8196 12 65 65 CD cord-010119-t1x9gknd 8196 13 % % NN cord-010119-t1x9gknd 8196 14 of of IN cord-010119-t1x9gknd 8196 15 cases case NNS cord-010119-t1x9gknd 8196 16 , , , cord-010119-t1x9gknd 8196 17 and and CC cord-010119-t1x9gknd 8196 18 all all DT cord-010119-t1x9gknd 8196 19 showed show VBD cord-010119-t1x9gknd 8196 20 no no DT cord-010119-t1x9gknd 8196 21 evidence evidence NN cord-010119-t1x9gknd 8196 22 of of IN cord-010119-t1x9gknd 8196 23 pulmonary pulmonary JJ cord-010119-t1x9gknd 8196 24 edema edema NN cord-010119-t1x9gknd 8196 25 to to TO cord-010119-t1x9gknd 8196 26 suggest suggest VB cord-010119-t1x9gknd 8196 27 possible possible JJ cord-010119-t1x9gknd 8196 28 volume volume NN cord-010119-t1x9gknd 8196 29 overload overload NN cord-010119-t1x9gknd 8196 30 / / SYM cord-010119-t1x9gknd 8196 31 transfusion transfusion NN cord-010119-t1x9gknd 8196 32 associated associate VBD cord-010119-t1x9gknd 8196 33 circulatory circulatory JJ cord-010119-t1x9gknd 8196 34 overload overload NN cord-010119-t1x9gknd 8196 35 ( ( -LRB- cord-010119-t1x9gknd 8196 36 TACO TACO NNP cord-010119-t1x9gknd 8196 37 ) ) -RRB- cord-010119-t1x9gknd 8196 38 . . . cord-010119-t1x9gknd 8197 1 Electrocardiogram Electrocardiogram NNP cord-010119-t1x9gknd 8197 2 was be VBD cord-010119-t1x9gknd 8197 3 performed perform VBN cord-010119-t1x9gknd 8197 4 in in IN cord-010119-t1x9gknd 8197 5 70 70 CD cord-010119-t1x9gknd 8197 6 % % NN cord-010119-t1x9gknd 8197 7 of of IN cord-010119-t1x9gknd 8197 8 cases case NNS cord-010119-t1x9gknd 8197 9 and and CC cord-010119-t1x9gknd 8197 10 showed show VBD cord-010119-t1x9gknd 8197 11 no no DT cord-010119-t1x9gknd 8197 12 findings finding NNS cord-010119-t1x9gknd 8197 13 to to TO cord-010119-t1x9gknd 8197 14 suggest suggest VB cord-010119-t1x9gknd 8197 15 acute acute JJ cord-010119-t1x9gknd 8197 16 ischemia ischemia NN cord-010119-t1x9gknd 8197 17 . . . cord-010119-t1x9gknd 8198 1 Three three CD cord-010119-t1x9gknd 8198 2 ( ( -LRB- cord-010119-t1x9gknd 8198 3 15 15 CD cord-010119-t1x9gknd 8198 4 % % NN cord-010119-t1x9gknd 8198 5 ) ) -RRB- cord-010119-t1x9gknd 8199 1 patients patient NNS cord-010119-t1x9gknd 8199 2 had have VBD cord-010119-t1x9gknd 8199 3 a a DT cord-010119-t1x9gknd 8199 4 minimal minimal JJ cord-010119-t1x9gknd 8199 5 increase increase NN cord-010119-t1x9gknd 8199 6 in in IN cord-010119-t1x9gknd 8199 7 their -PRON- PRP$ cord-010119-t1x9gknd 8199 8 troponin troponin JJ cord-010119-t1x9gknd 8199 9 levels level NNS cord-010119-t1x9gknd 8199 10 , , , cord-010119-t1x9gknd 8199 11 although although IN cord-010119-t1x9gknd 8199 12 1 1 CD cord-010119-t1x9gknd 8199 13 had have VBD cord-010119-t1x9gknd 8199 14 a a DT cord-010119-t1x9gknd 8199 15 history history NN cord-010119-t1x9gknd 8199 16 of of IN cord-010119-t1x9gknd 8199 17 chronically chronically RB cord-010119-t1x9gknd 8199 18 elevated elevated JJ cord-010119-t1x9gknd 8199 19 troponin troponin NN cord-010119-t1x9gknd 8199 20 due due IN cord-010119-t1x9gknd 8199 21 to to IN cord-010119-t1x9gknd 8199 22 stress stress NN cord-010119-t1x9gknd 8199 23 cardiomyopathy cardiomyopathy NN cord-010119-t1x9gknd 8199 24 . . . cord-010119-t1x9gknd 8200 1 Fourteen fourteen CD cord-010119-t1x9gknd 8200 2 ( ( -LRB- cord-010119-t1x9gknd 8200 3 70 70 CD cord-010119-t1x9gknd 8200 4 % % NN cord-010119-t1x9gknd 8200 5 ) ) -RRB- cord-010119-t1x9gknd 8200 6 patients patient NNS cord-010119-t1x9gknd 8200 7 received receive VBD cord-010119-t1x9gknd 8200 8 some some DT cord-010119-t1x9gknd 8200 9 form form NN cord-010119-t1x9gknd 8200 10 of of IN cord-010119-t1x9gknd 8200 11 treatment treatment NN cord-010119-t1x9gknd 8200 12 , , , cord-010119-t1x9gknd 8200 13 including include VBG cord-010119-t1x9gknd 8200 14 increased increase VBN cord-010119-t1x9gknd 8200 15 oxygen oxygen NN cord-010119-t1x9gknd 8200 16 supplementation supplementation NN cord-010119-t1x9gknd 8200 17 , , , cord-010119-t1x9gknd 8200 18 metoprolol metoprolol NN cord-010119-t1x9gknd 8200 19 , , , cord-010119-t1x9gknd 8200 20 acetaminophen acetaminophen NN cord-010119-t1x9gknd 8200 21 , , , cord-010119-t1x9gknd 8200 22 morphine morphine NN cord-010119-t1x9gknd 8200 23 , , , cord-010119-t1x9gknd 8200 24 and and CC cord-010119-t1x9gknd 8200 25 oral oral JJ cord-010119-t1x9gknd 8200 26 calcium calcium NN cord-010119-t1x9gknd 8200 27 carbonate carbonate NN cord-010119-t1x9gknd 8200 28 ; ; : cord-010119-t1x9gknd 8200 29 the the DT cord-010119-t1x9gknd 8200 30 pain pain NN cord-010119-t1x9gknd 8200 31 resolved resolve VBN cord-010119-t1x9gknd 8200 32 after after IN cord-010119-t1x9gknd 8200 33 more more JJR cord-010119-t1x9gknd 8200 34 than than IN cord-010119-t1x9gknd 8200 35 10 10 CD cord-010119-t1x9gknd 8200 36 minutes minute NNS cord-010119-t1x9gknd 8200 37 in in IN cord-010119-t1x9gknd 8200 38 the the DT cord-010119-t1x9gknd 8200 39 majority majority NN cord-010119-t1x9gknd 8200 40 of of IN cord-010119-t1x9gknd 8200 41 patients patient NNS cord-010119-t1x9gknd 8200 42 ( ( -LRB- cord-010119-t1x9gknd 8200 43 90 90 CD cord-010119-t1x9gknd 8200 44 % % NN cord-010119-t1x9gknd 8200 45 ) ) -RRB- cord-010119-t1x9gknd 8200 46 . . . cord-010119-t1x9gknd 8201 1 No no DT cord-010119-t1x9gknd 8201 2 cases case NNS cord-010119-t1x9gknd 8201 3 resulted result VBD cord-010119-t1x9gknd 8201 4 in in IN cord-010119-t1x9gknd 8201 5 new new JJ cord-010119-t1x9gknd 8201 6 admission admission NN cord-010119-t1x9gknd 8201 7 to to IN cord-010119-t1x9gknd 8201 8 the the DT cord-010119-t1x9gknd 8201 9 ICU ICU NNP cord-010119-t1x9gknd 8201 10 or or CC cord-010119-t1x9gknd 8201 11 procedure procedure NN cord-010119-t1x9gknd 8201 12 cancelation cancelation NN cord-010119-t1x9gknd 8201 13 . . . cord-010119-t1x9gknd 8202 1 Conclusion conclusion NN cord-010119-t1x9gknd 8202 2 : : : cord-010119-t1x9gknd 8202 3 Chest chest NN cord-010119-t1x9gknd 8202 4 pain pain NN cord-010119-t1x9gknd 8202 5 associated associate VBN cord-010119-t1x9gknd 8202 6 with with IN cord-010119-t1x9gknd 8202 7 transfusion transfusion NN cord-010119-t1x9gknd 8202 8 was be VBD cord-010119-t1x9gknd 8202 9 infrequent infrequent JJ cord-010119-t1x9gknd 8202 10 , , , cord-010119-t1x9gknd 8202 11 but but CC cord-010119-t1x9gknd 8202 12 several several JJ cord-010119-t1x9gknd 8202 13 such such JJ cord-010119-t1x9gknd 8202 14 cases case NNS cord-010119-t1x9gknd 8202 15 were be VBD cord-010119-t1x9gknd 8202 16 identified identify VBN cord-010119-t1x9gknd 8202 17 during during IN cord-010119-t1x9gknd 8202 18 the the DT cord-010119-t1x9gknd 8202 19 review review NN cord-010119-t1x9gknd 8202 20 period period NN cord-010119-t1x9gknd 8202 21 . . . cord-010119-t1x9gknd 8203 1 This this DT cord-010119-t1x9gknd 8203 2 symptom symptom NN cord-010119-t1x9gknd 8203 3 is be VBZ cord-010119-t1x9gknd 8203 4 not not RB cord-010119-t1x9gknd 8203 5 a a DT cord-010119-t1x9gknd 8203 6 diagnostic diagnostic JJ cord-010119-t1x9gknd 8203 7 criterion criterion NN cord-010119-t1x9gknd 8203 8 for for IN cord-010119-t1x9gknd 8203 9 any any DT cord-010119-t1x9gknd 8203 10 of of IN cord-010119-t1x9gknd 8203 11 the the DT cord-010119-t1x9gknd 8203 12 other other JJ cord-010119-t1x9gknd 8203 13 Hemovigilance Hemovigilance NNP cord-010119-t1x9gknd 8203 14 categories category NNS cord-010119-t1x9gknd 8203 15 and and CC cord-010119-t1x9gknd 8203 16 merits merit NNS cord-010119-t1x9gknd 8203 17 further further JJ cord-010119-t1x9gknd 8203 18 characterization characterization NN cord-010119-t1x9gknd 8203 19 to to TO cord-010119-t1x9gknd 8203 20 determine determine VB cord-010119-t1x9gknd 8203 21 whether whether IN cord-010119-t1x9gknd 8203 22 blood blood NN cord-010119-t1x9gknd 8203 23 product product NN cord-010119-t1x9gknd 8203 24 transfusion transfusion NN cord-010119-t1x9gknd 8203 25 could could MD cord-010119-t1x9gknd 8203 26 be be VB cord-010119-t1x9gknd 8203 27 the the DT cord-010119-t1x9gknd 8203 28 cause cause NN cord-010119-t1x9gknd 8203 29 of of IN cord-010119-t1x9gknd 8203 30 the the DT cord-010119-t1x9gknd 8203 31 chest chest NN cord-010119-t1x9gknd 8203 32 pain pain NN cord-010119-t1x9gknd 8203 33 . . . cord-010119-t1x9gknd 8204 1 Larger large JJR cord-010119-t1x9gknd 8204 2 observational observational JJ cord-010119-t1x9gknd 8204 3 studies study NNS cord-010119-t1x9gknd 8204 4 to to TO cord-010119-t1x9gknd 8204 5 power power VB cord-010119-t1x9gknd 8204 6 clinical clinical JJ cord-010119-t1x9gknd 8204 7 characterization characterization NN cord-010119-t1x9gknd 8204 8 could could MD cord-010119-t1x9gknd 8204 9 help help VB cord-010119-t1x9gknd 8204 10 to to TO cord-010119-t1x9gknd 8204 11 further further RB cord-010119-t1x9gknd 8204 12 inform inform VB cord-010119-t1x9gknd 8204 13 hypotheses hypothesis NNS cord-010119-t1x9gknd 8204 14 regarding regard VBG cord-010119-t1x9gknd 8204 15 a a DT cord-010119-t1x9gknd 8204 16 transfusion transfusion NN cord-010119-t1x9gknd 8204 17 - - HYPH cord-010119-t1x9gknd 8204 18 related relate VBN cord-010119-t1x9gknd 8204 19 mechanism mechanism NN cord-010119-t1x9gknd 8204 20 , , , cord-010119-t1x9gknd 8204 21 which which WDT cord-010119-t1x9gknd 8204 22 could could MD cord-010119-t1x9gknd 8204 23 be be VB cord-010119-t1x9gknd 8204 24 interrogated interrogate VBN cord-010119-t1x9gknd 8204 25 by by IN cord-010119-t1x9gknd 8204 26 translational translational JJ cord-010119-t1x9gknd 8204 27 research research NN cord-010119-t1x9gknd 8204 28 studies study NNS cord-010119-t1x9gknd 8204 29 . . . cord-010119-t1x9gknd 8205 1 Background Background NNP cord-010119-t1x9gknd 8205 2 / / SYM cord-010119-t1x9gknd 8205 3 Case Case NNP cord-010119-t1x9gknd 8205 4 Studies Studies NNPS cord-010119-t1x9gknd 8205 5 : : : cord-010119-t1x9gknd 8206 1 Thrombotic thrombotic JJ cord-010119-t1x9gknd 8206 2 microangiopathy microangiopathy NN cord-010119-t1x9gknd 8206 3 ( ( -LRB- cord-010119-t1x9gknd 8206 4 TMA TMA NNP cord-010119-t1x9gknd 8206 5 ) ) -RRB- cord-010119-t1x9gknd 8206 6 in in IN cord-010119-t1x9gknd 8206 7 children child NNS cord-010119-t1x9gknd 8206 8 is be VBZ cord-010119-t1x9gknd 8206 9 most most RBS cord-010119-t1x9gknd 8206 10 commonly commonly RB cord-010119-t1x9gknd 8206 11 seen see VBN cord-010119-t1x9gknd 8206 12 in in IN cord-010119-t1x9gknd 8206 13 the the DT cord-010119-t1x9gknd 8206 14 form form NN cord-010119-t1x9gknd 8206 15 of of IN cord-010119-t1x9gknd 8206 16 hemolytic hemolytic JJ cord-010119-t1x9gknd 8206 17 uremic uremic JJ cord-010119-t1x9gknd 8206 18 syndrome syndrome NN cord-010119-t1x9gknd 8206 19 ( ( -LRB- cord-010119-t1x9gknd 8206 20 HUS HUS NNP cord-010119-t1x9gknd 8206 21 ) ) -RRB- cord-010119-t1x9gknd 8206 22 . . . cord-010119-t1x9gknd 8207 1 However however RB cord-010119-t1x9gknd 8207 2 , , , cord-010119-t1x9gknd 8207 3 TMA TMA NNP cord-010119-t1x9gknd 8207 4 may may MD cord-010119-t1x9gknd 8207 5 be be VB cord-010119-t1x9gknd 8207 6 seen see VBN cord-010119-t1x9gknd 8207 7 in in IN cord-010119-t1x9gknd 8207 8 the the DT cord-010119-t1x9gknd 8207 9 presence presence NN cord-010119-t1x9gknd 8207 10 of of IN cord-010119-t1x9gknd 8207 11 Streptococcus Streptococcus NNP cord-010119-t1x9gknd 8207 12 pneumoniae pneumoniae NN cord-010119-t1x9gknd 8207 13 ( ( -LRB- cord-010119-t1x9gknd 8207 14 SPN SPN NNP cord-010119-t1x9gknd 8207 15 ) ) -RRB- cord-010119-t1x9gknd 8207 16 . . . cord-010119-t1x9gknd 8208 1 The the DT cord-010119-t1x9gknd 8208 2 action action NN cord-010119-t1x9gknd 8208 3 of of IN cord-010119-t1x9gknd 8208 4 bacterial bacterial JJ cord-010119-t1x9gknd 8208 5 neuraminidase neuraminidase NN cord-010119-t1x9gknd 8208 6 of of IN cord-010119-t1x9gknd 8208 7 SPN SPN NNP cord-010119-t1x9gknd 8208 8 results result NNS cord-010119-t1x9gknd 8208 9 in in IN cord-010119-t1x9gknd 8208 10 exposure exposure NN cord-010119-t1x9gknd 8208 11 of of IN cord-010119-t1x9gknd 8208 12 the the DT cord-010119-t1x9gknd 8208 13 normally normally RB cord-010119-t1x9gknd 8208 14 " " `` cord-010119-t1x9gknd 8208 15 hidden hide VBN cord-010119-t1x9gknd 8208 16 " " '' cord-010119-t1x9gknd 8208 17 Thomsen Thomsen NNP cord-010119-t1x9gknd 8208 18 - - HYPH cord-010119-t1x9gknd 8208 19 Freidenreich Freidenreich NNP cord-010119-t1x9gknd 8208 20 antigen antigen NN cord-010119-t1x9gknd 8208 21 ( ( -LRB- cord-010119-t1x9gknd 8208 22 T t NN cord-010119-t1x9gknd 8208 23 - - HYPH cord-010119-t1x9gknd 8208 24 antigen antigen NNP cord-010119-t1x9gknd 8208 25 ) ) -RRB- cord-010119-t1x9gknd 8208 26 found find VBD cord-010119-t1x9gknd 8208 27 on on IN cord-010119-t1x9gknd 8208 28 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 8208 29 and and CC cord-010119-t1x9gknd 8208 30 other other JJ cord-010119-t1x9gknd 8208 31 tissues tissue NNS cord-010119-t1x9gknd 8208 32 . . . cord-010119-t1x9gknd 8209 1 Ultimately ultimately RB cord-010119-t1x9gknd 8209 2 , , , cord-010119-t1x9gknd 8209 3 this this DT cord-010119-t1x9gknd 8209 4 may may MD cord-010119-t1x9gknd 8209 5 lead lead VB cord-010119-t1x9gknd 8209 6 to to IN cord-010119-t1x9gknd 8209 7 SPN SPN NNP cord-010119-t1x9gknd 8209 8 induced induce VBN cord-010119-t1x9gknd 8209 9 hemolytic hemolytic JJ cord-010119-t1x9gknd 8209 10 uremic uremic JJ cord-010119-t1x9gknd 8209 11 syndrome syndrome NN cord-010119-t1x9gknd 8209 12 ( ( -LRB- cord-010119-t1x9gknd 8209 13 pHUS phus NN cord-010119-t1x9gknd 8209 14 ) ) -RRB- cord-010119-t1x9gknd 8209 15 with with IN cord-010119-t1x9gknd 8209 16 subsequent subsequent JJ cord-010119-t1x9gknd 8209 17 hemolysis hemolysis NN cord-010119-t1x9gknd 8209 18 and and CC cord-010119-t1x9gknd 8209 19 end end VB cord-010119-t1x9gknd 8209 20 organ organ NN cord-010119-t1x9gknd 8209 21 damage damage NN cord-010119-t1x9gknd 8209 22 by by IN cord-010119-t1x9gknd 8209 23 naturally naturally RB cord-010119-t1x9gknd 8209 24 occurring occur VBG cord-010119-t1x9gknd 8209 25 anti anti JJ cord-010119-t1x9gknd 8209 26 - - JJ cord-010119-t1x9gknd 8209 27 T t JJ cord-010119-t1x9gknd 8209 28 antibodies antibody NNS cord-010119-t1x9gknd 8209 29 against against IN cord-010119-t1x9gknd 8209 30 the the DT cord-010119-t1x9gknd 8209 31 exposed expose VBN cord-010119-t1x9gknd 8209 32 T t NN cord-010119-t1x9gknd 8209 33 antigen antigen NN cord-010119-t1x9gknd 8209 34 . . . cord-010119-t1x9gknd 8210 1 Specific specific JJ cord-010119-t1x9gknd 8210 2 lectins lectin NNS cord-010119-t1x9gknd 8210 3 or or CC cord-010119-t1x9gknd 8210 4 anti anti JJ cord-010119-t1x9gknd 8210 5 - - JJ cord-010119-t1x9gknd 8210 6 sera sera JJ cord-010119-t1x9gknd 8210 7 can can MD cord-010119-t1x9gknd 8210 8 confirm confirm VB cord-010119-t1x9gknd 8210 9 exposure exposure NN cord-010119-t1x9gknd 8210 10 of of IN cord-010119-t1x9gknd 8210 11 the the DT cord-010119-t1x9gknd 8210 12 T T NNP cord-010119-t1x9gknd 8210 13 antigens antigen NNS cord-010119-t1x9gknd 8210 14 in in IN cord-010119-t1x9gknd 8210 15 pHUS phus NN cord-010119-t1x9gknd 8210 16 . . . cord-010119-t1x9gknd 8211 1 Alternatively alternatively RB cord-010119-t1x9gknd 8211 2 , , , cord-010119-t1x9gknd 8211 3 pHUS phus NN cord-010119-t1x9gknd 8211 4 can can MD cord-010119-t1x9gknd 8211 5 be be VB cord-010119-t1x9gknd 8211 6 identified identify VBN cord-010119-t1x9gknd 8211 7 by by IN cord-010119-t1x9gknd 8211 8 minor minor JJ cord-010119-t1x9gknd 8211 9 crossmatch crossmatch NN cord-010119-t1x9gknd 8211 10 incompatibility incompatibility NN cord-010119-t1x9gknd 8211 11 resulting result VBG cord-010119-t1x9gknd 8211 12 from from IN cord-010119-t1x9gknd 8211 13 agglutination agglutination NN cord-010119-t1x9gknd 8211 14 of of IN cord-010119-t1x9gknd 8211 15 exposed expose VBN cord-010119-t1x9gknd 8211 16 T t NN cord-010119-t1x9gknd 8211 17 antigens antigen NNS cord-010119-t1x9gknd 8211 18 on on IN cord-010119-t1x9gknd 8211 19 recipient recipient NN cord-010119-t1x9gknd 8211 20 's 's POS cord-010119-t1x9gknd 8211 21 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 8211 22 to to IN cord-010119-t1x9gknd 8211 23 anti anti JJ cord-010119-t1x9gknd 8211 24 - - JJ cord-010119-t1x9gknd 8211 25 T t JJ cord-010119-t1x9gknd 8211 26 antibodies antibody NNS cord-010119-t1x9gknd 8211 27 in in IN cord-010119-t1x9gknd 8211 28 the the DT cord-010119-t1x9gknd 8211 29 plasma plasma NN cord-010119-t1x9gknd 8211 30 portion portion NN cord-010119-t1x9gknd 8211 31 of of IN cord-010119-t1x9gknd 8211 32 blood blood NN cord-010119-t1x9gknd 8211 33 products product NNS cord-010119-t1x9gknd 8211 34 . . . cord-010119-t1x9gknd 8212 1 We -PRON- PRP cord-010119-t1x9gknd 8212 2 present present VBP cord-010119-t1x9gknd 8212 3 a a DT cord-010119-t1x9gknd 8212 4 case case NN cord-010119-t1x9gknd 8212 5 of of IN cord-010119-t1x9gknd 8212 6 suspected suspect VBN cord-010119-t1x9gknd 8212 7 pHUS phus NN cord-010119-t1x9gknd 8212 8 that that WDT cord-010119-t1x9gknd 8212 9 resulted result VBD cord-010119-t1x9gknd 8212 10 in in IN cord-010119-t1x9gknd 8212 11 a a DT cord-010119-t1x9gknd 8212 12 compatible compatible JJ cord-010119-t1x9gknd 8212 13 minor minor JJ cord-010119-t1x9gknd 8212 14 crossmatch crossmatch NN cord-010119-t1x9gknd 8212 15 leading lead VBG cord-010119-t1x9gknd 8212 16 to to IN cord-010119-t1x9gknd 8212 17 concern concern NN cord-010119-t1x9gknd 8212 18 and and CC cord-010119-t1x9gknd 8212 19 eventually eventually RB cord-010119-t1x9gknd 8212 20 diagnosis diagnosis NN cord-010119-t1x9gknd 8212 21 of of IN cord-010119-t1x9gknd 8212 22 atypical atypical JJ cord-010119-t1x9gknd 8212 23 HUS HUS NNP cord-010119-t1x9gknd 8212 24 ( ( -LRB- cord-010119-t1x9gknd 8212 25 aHUS ahus NN cord-010119-t1x9gknd 8212 26 ) ) -RRB- cord-010119-t1x9gknd 8212 27 . . . cord-010119-t1x9gknd 8213 1 Study Study NNP cord-010119-t1x9gknd 8213 2 Design Design NNP cord-010119-t1x9gknd 8213 3 / / SYM cord-010119-t1x9gknd 8213 4 Method method NN cord-010119-t1x9gknd 8213 5 : : : cord-010119-t1x9gknd 8214 1 A a DT cord-010119-t1x9gknd 8214 2 6 6 CD cord-010119-t1x9gknd 8214 3 months month NNS cord-010119-t1x9gknd 8214 4 old old JJ cord-010119-t1x9gknd 8214 5 boy boy NN cord-010119-t1x9gknd 8214 6 presented present VBN cord-010119-t1x9gknd 8214 7 with with IN cord-010119-t1x9gknd 8214 8 respiratory respiratory JJ cord-010119-t1x9gknd 8214 9 failure failure NN cord-010119-t1x9gknd 8214 10 . . . cord-010119-t1x9gknd 8215 1 He -PRON- PRP cord-010119-t1x9gknd 8215 2 was be VBD cord-010119-t1x9gknd 8215 3 found find VBN cord-010119-t1x9gknd 8215 4 to to TO cord-010119-t1x9gknd 8215 5 have have VB cord-010119-t1x9gknd 8215 6 blood blood NN cord-010119-t1x9gknd 8215 7 cultures culture NNS cord-010119-t1x9gknd 8215 8 positive positive JJ cord-010119-t1x9gknd 8215 9 for for IN cord-010119-t1x9gknd 8215 10 SPN SPN NNP cord-010119-t1x9gknd 8215 11 as as RB cord-010119-t1x9gknd 8215 12 well well RB cord-010119-t1x9gknd 8215 13 as as IN cord-010119-t1x9gknd 8215 14 hemolytic hemolytic JJ cord-010119-t1x9gknd 8215 15 anemia anemia NN cord-010119-t1x9gknd 8215 16 , , , cord-010119-t1x9gknd 8215 17 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 8215 18 , , , cord-010119-t1x9gknd 8215 19 and and CC cord-010119-t1x9gknd 8215 20 acute acute JJ cord-010119-t1x9gknd 8215 21 renal renal JJ cord-010119-t1x9gknd 8215 22 failure failure NN cord-010119-t1x9gknd 8215 23 . . . cord-010119-t1x9gknd 8216 1 He -PRON- PRP cord-010119-t1x9gknd 8216 2 was be VBD cord-010119-t1x9gknd 8216 3 Shiga Shiga NNP cord-010119-t1x9gknd 8216 4 toxin toxin NN cord-010119-t1x9gknd 8216 5 negative negative JJ cord-010119-t1x9gknd 8216 6 and and CC cord-010119-t1x9gknd 8216 7 had have VBD cord-010119-t1x9gknd 8216 8 normal normal JJ cord-010119-t1x9gknd 8216 9 levels level NNS cord-010119-t1x9gknd 8216 10 of of IN cord-010119-t1x9gknd 8216 11 ADAMTS ADAMTS NNP cord-010119-t1x9gknd 8216 12 13 13 CD cord-010119-t1x9gknd 8216 13 . . . cord-010119-t1x9gknd 8217 1 Based base VBN cord-010119-t1x9gknd 8217 2 on on IN cord-010119-t1x9gknd 8217 3 the the DT cord-010119-t1x9gknd 8217 4 findings finding NNS cord-010119-t1x9gknd 8217 5 , , , cord-010119-t1x9gknd 8217 6 the the DT cord-010119-t1x9gknd 8217 7 clinical clinical JJ cord-010119-t1x9gknd 8217 8 team team NN cord-010119-t1x9gknd 8217 9 was be VBD cord-010119-t1x9gknd 8217 10 concerned concern VBN cord-010119-t1x9gknd 8217 11 for for IN cord-010119-t1x9gknd 8217 12 pHUS phus NN cord-010119-t1x9gknd 8217 13 . . . cord-010119-t1x9gknd 8218 1 Therefore therefore RB cord-010119-t1x9gknd 8218 2 , , , cord-010119-t1x9gknd 8218 3 he -PRON- PRP cord-010119-t1x9gknd 8218 4 received receive VBD cord-010119-t1x9gknd 8218 5 washed washed JJ cord-010119-t1x9gknd 8218 6 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 8218 7 . . . cord-010119-t1x9gknd 8219 1 For for IN cord-010119-t1x9gknd 8219 2 his -PRON- PRP$ cord-010119-t1x9gknd 8219 3 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 8219 4 , , , cord-010119-t1x9gknd 8219 5 our -PRON- PRP$ cord-010119-t1x9gknd 8219 6 institution institution NN cord-010119-t1x9gknd 8219 7 does do VBZ cord-010119-t1x9gknd 8219 8 not not RB cord-010119-t1x9gknd 8219 9 routinely routinely RB cord-010119-t1x9gknd 8219 10 provide provide VB cord-010119-t1x9gknd 8219 11 washed washed JJ cord-010119-t1x9gknd 8219 12 platelets platelet NNS cord-010119-t1x9gknd 8219 13 due due JJ cord-010119-t1x9gknd 8219 14 to to TO cord-010119-t1x9gknd 8219 15 decrease decrease VB cord-010119-t1x9gknd 8219 16 quality quality NN cord-010119-t1x9gknd 8219 17 of of IN cord-010119-t1x9gknd 8219 18 the the DT cord-010119-t1x9gknd 8219 19 platelet platelet NN cord-010119-t1x9gknd 8219 20 product product NN cord-010119-t1x9gknd 8219 21 . . . cord-010119-t1x9gknd 8220 1 As as IN cord-010119-t1x9gknd 8220 2 a a DT cord-010119-t1x9gknd 8220 3 result result NN cord-010119-t1x9gknd 8220 4 , , , cord-010119-t1x9gknd 8220 5 a a DT cord-010119-t1x9gknd 8220 6 minor minor JJ cord-010119-t1x9gknd 8220 7 crossmatching crossmatching NN cord-010119-t1x9gknd 8220 8 was be VBD cord-010119-t1x9gknd 8220 9 suggested suggest VBN cord-010119-t1x9gknd 8220 10 and and CC cord-010119-t1x9gknd 8220 11 performed perform VBN cord-010119-t1x9gknd 8220 12 to to TO cord-010119-t1x9gknd 8220 13 determine determine VB cord-010119-t1x9gknd 8220 14 if if IN cord-010119-t1x9gknd 8220 15 T T NNP cord-010119-t1x9gknd 8220 16 activation activation NN cord-010119-t1x9gknd 8220 17 was be VBD cord-010119-t1x9gknd 8220 18 present present JJ cord-010119-t1x9gknd 8220 19 . . . cord-010119-t1x9gknd 8221 1 Results/ Results/ . cord-010119-t1x9gknd 8222 1 Finding finding NN cord-010119-t1x9gknd 8222 2 : : : cord-010119-t1x9gknd 8223 1 Minor minor JJ cord-010119-t1x9gknd 8223 2 crossmatch crossmatch NN cord-010119-t1x9gknd 8223 3 was be VBD cord-010119-t1x9gknd 8223 4 performed perform VBN cord-010119-t1x9gknd 8223 5 with with IN cord-010119-t1x9gknd 8223 6 patient patient NN cord-010119-t1x9gknd 8223 7 's 's POS cord-010119-t1x9gknd 8223 8 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 8223 9 and and CC cord-010119-t1x9gknd 8223 10 plasma plasma NN cord-010119-t1x9gknd 8223 11 of of IN cord-010119-t1x9gknd 8223 12 ABO ABO NNP cord-010119-t1x9gknd 8223 13 - - HYPH cord-010119-t1x9gknd 8223 14 identical identical JJ cord-010119-t1x9gknd 8223 15 platelets platelet NNS cord-010119-t1x9gknd 8223 16 to to TO cord-010119-t1x9gknd 8223 17 be be VB cord-010119-t1x9gknd 8223 18 transfused transfuse VBN cord-010119-t1x9gknd 8223 19 . . . cord-010119-t1x9gknd 8224 1 No no DT cord-010119-t1x9gknd 8224 2 agglutination agglutination NN cord-010119-t1x9gknd 8224 3 was be VBD cord-010119-t1x9gknd 8224 4 seen see VBN cord-010119-t1x9gknd 8224 5 at at IN cord-010119-t1x9gknd 8224 6 immediate immediate JJ cord-010119-t1x9gknd 8224 7 spin spin NN cord-010119-t1x9gknd 8224 8 , , , cord-010119-t1x9gknd 8224 9 37 37 CD cord-010119-t1x9gknd 8224 10 degree degree NN cord-010119-t1x9gknd 8224 11 , , , cord-010119-t1x9gknd 8224 12 or or CC cord-010119-t1x9gknd 8224 13 anti anti JJ cord-010119-t1x9gknd 8224 14 - - JJ cord-010119-t1x9gknd 8224 15 human human JJ cord-010119-t1x9gknd 8224 16 globulin globulin NN cord-010119-t1x9gknd 8224 17 phase phase NN cord-010119-t1x9gknd 8224 18 . . . cord-010119-t1x9gknd 8225 1 Check check NN cord-010119-t1x9gknd 8225 2 cells cell NNS cord-010119-t1x9gknd 8225 3 were be VBD cord-010119-t1x9gknd 8225 4 found find VBN cord-010119-t1x9gknd 8225 5 to to TO cord-010119-t1x9gknd 8225 6 be be VB cord-010119-t1x9gknd 8225 7 21 21 CD cord-010119-t1x9gknd 8225 8 . . . cord-010119-t1x9gknd 8226 1 These these DT cord-010119-t1x9gknd 8226 2 findings finding NNS cord-010119-t1x9gknd 8226 3 were be VBD cord-010119-t1x9gknd 8226 4 conveyed convey VBN cord-010119-t1x9gknd 8226 5 to to IN cord-010119-t1x9gknd 8226 6 the the DT cord-010119-t1x9gknd 8226 7 clinical clinical JJ cord-010119-t1x9gknd 8226 8 team team NN cord-010119-t1x9gknd 8226 9 and and CC cord-010119-t1x9gknd 8226 10 platelets platelet NNS cord-010119-t1x9gknd 8226 11 were be VBD cord-010119-t1x9gknd 8226 12 issued issue VBN cord-010119-t1x9gknd 8226 13 without without IN cord-010119-t1x9gknd 8226 14 washing wash VBG cord-010119-t1x9gknd 8226 15 . . . cord-010119-t1x9gknd 8227 1 Due due IN cord-010119-t1x9gknd 8227 2 to to IN cord-010119-t1x9gknd 8227 3 the the DT cord-010119-t1x9gknd 8227 4 lack lack NN cord-010119-t1x9gknd 8227 5 of of IN cord-010119-t1x9gknd 8227 6 identification identification NN cord-010119-t1x9gknd 8227 7 of of IN cord-010119-t1x9gknd 8227 8 T T NNP cord-010119-t1x9gknd 8227 9 activation activation NN cord-010119-t1x9gknd 8227 10 by by IN cord-010119-t1x9gknd 8227 11 minor minor JJ cord-010119-t1x9gknd 8227 12 crossmatching crossmatching NN cord-010119-t1x9gknd 8227 13 and and CC cord-010119-t1x9gknd 8227 14 poor poor JJ cord-010119-t1x9gknd 8227 15 clinical clinical JJ cord-010119-t1x9gknd 8227 16 response response NN cord-010119-t1x9gknd 8227 17 despite despite IN cord-010119-t1x9gknd 8227 18 appropriate appropriate JJ cord-010119-t1x9gknd 8227 19 antibiotic antibiotic JJ cord-010119-t1x9gknd 8227 20 treatment treatment NN cord-010119-t1x9gknd 8227 21 , , , cord-010119-t1x9gknd 8227 22 additional additional JJ cord-010119-t1x9gknd 8227 23 studies study NNS cord-010119-t1x9gknd 8227 24 were be VBD cord-010119-t1x9gknd 8227 25 performed perform VBN cord-010119-t1x9gknd 8227 26 by by IN cord-010119-t1x9gknd 8227 27 the the DT cord-010119-t1x9gknd 8227 28 primary primary JJ cord-010119-t1x9gknd 8227 29 team team NN cord-010119-t1x9gknd 8227 30 for for IN cord-010119-t1x9gknd 8227 31 complement complement JJ cord-010119-t1x9gknd 8227 32 mutations mutation NNS cord-010119-t1x9gknd 8227 33 and and CC cord-010119-t1x9gknd 8227 34 found find VBD cord-010119-t1x9gknd 8227 35 to to TO cord-010119-t1x9gknd 8227 36 be be VB cord-010119-t1x9gknd 8227 37 consistent consistent JJ cord-010119-t1x9gknd 8227 38 with with IN cord-010119-t1x9gknd 8227 39 aHUS ahus DT cord-010119-t1x9gknd 8227 40 . . . cord-010119-t1x9gknd 8228 1 The the DT cord-010119-t1x9gknd 8228 2 patient patient NN cord-010119-t1x9gknd 8228 3 was be VBD cord-010119-t1x9gknd 8228 4 then then RB cord-010119-t1x9gknd 8228 5 treated treat VBN cord-010119-t1x9gknd 8228 6 with with IN cord-010119-t1x9gknd 8228 7 Eculizumab Eculizumab NNP cord-010119-t1x9gknd 8228 8 with with IN cord-010119-t1x9gknd 8228 9 clinical clinical JJ cord-010119-t1x9gknd 8228 10 and and CC cord-010119-t1x9gknd 8228 11 laboratory laboratory NN cord-010119-t1x9gknd 8228 12 improvement improvement NN cord-010119-t1x9gknd 8228 13 . . . cord-010119-t1x9gknd 8229 1 We -PRON- PRP cord-010119-t1x9gknd 8229 2 present present VBP cord-010119-t1x9gknd 8229 3 a a DT cord-010119-t1x9gknd 8229 4 case case NN cord-010119-t1x9gknd 8229 5 clinically clinically RB cord-010119-t1x9gknd 8229 6 consistent consistent JJ cord-010119-t1x9gknd 8229 7 with with IN cord-010119-t1x9gknd 8229 8 pHUS phus NN cord-010119-t1x9gknd 8229 9 . . . cord-010119-t1x9gknd 8230 1 Confirmation confirmation NN cord-010119-t1x9gknd 8230 2 of of IN cord-010119-t1x9gknd 8230 3 this this DT cord-010119-t1x9gknd 8230 4 diagnosis diagnosis NN cord-010119-t1x9gknd 8230 5 is be VBZ cord-010119-t1x9gknd 8230 6 done do VBN cord-010119-t1x9gknd 8230 7 with with IN cord-010119-t1x9gknd 8230 8 lectins lectin NNS cord-010119-t1x9gknd 8230 9 or or CC cord-010119-t1x9gknd 8230 10 anti anti JJ cord-010119-t1x9gknd 8230 11 - - JJ cord-010119-t1x9gknd 8230 12 sera sera JJ cord-010119-t1x9gknd 8230 13 that that WDT cord-010119-t1x9gknd 8230 14 are be VBP cord-010119-t1x9gknd 8230 15 not not RB cord-010119-t1x9gknd 8230 16 readily readily RB cord-010119-t1x9gknd 8230 17 available available JJ cord-010119-t1x9gknd 8230 18 . . . cord-010119-t1x9gknd 8231 1 An an DT cord-010119-t1x9gknd 8231 2 alternative alternative JJ cord-010119-t1x9gknd 8231 3 means mean NNS cord-010119-t1x9gknd 8231 4 of of IN cord-010119-t1x9gknd 8231 5 identifying identify VBG cord-010119-t1x9gknd 8231 6 pHUS phus NN cord-010119-t1x9gknd 8231 7 is be VBZ cord-010119-t1x9gknd 8231 8 by by IN cord-010119-t1x9gknd 8231 9 minor minor JJ cord-010119-t1x9gknd 8231 10 crossmatch crossmatch NN cord-010119-t1x9gknd 8231 11 incompatibility incompatibility NN cord-010119-t1x9gknd 8231 12 . . . cord-010119-t1x9gknd 8232 1 By by IN cord-010119-t1x9gknd 8232 2 demonstrating demonstrate VBG cord-010119-t1x9gknd 8232 3 minor minor JJ cord-010119-t1x9gknd 8232 4 crossmatch crossmatch NN cord-010119-t1x9gknd 8232 5 compatibility compatibility NN cord-010119-t1x9gknd 8232 6 , , , cord-010119-t1x9gknd 8232 7 we -PRON- PRP cord-010119-t1x9gknd 8232 8 further further RB cord-010119-t1x9gknd 8232 9 elucidated elucidate VBD cord-010119-t1x9gknd 8232 10 a a DT cord-010119-t1x9gknd 8232 11 definitive definitive JJ cord-010119-t1x9gknd 8232 12 diagnosis diagnosis NN cord-010119-t1x9gknd 8232 13 of of IN cord-010119-t1x9gknd 8232 14 aHUS ahus DT cord-010119-t1x9gknd 8232 15 with with IN cord-010119-t1x9gknd 8232 16 appropriate appropriate JJ cord-010119-t1x9gknd 8232 17 management management NN cord-010119-t1x9gknd 8232 18 . . . cord-010119-t1x9gknd 8232 19 _SP cord-010119-t1x9gknd 8233 1 Background Background NNP cord-010119-t1x9gknd 8233 2 / / SYM cord-010119-t1x9gknd 8233 3 Case Case NNP cord-010119-t1x9gknd 8233 4 Studies Studies NNPS cord-010119-t1x9gknd 8233 5 : : : cord-010119-t1x9gknd 8233 6 Orthotopic Orthotopic NNP cord-010119-t1x9gknd 8233 7 liver liver NN cord-010119-t1x9gknd 8233 8 transplantation transplantation NN cord-010119-t1x9gknd 8233 9 ( ( -LRB- cord-010119-t1x9gknd 8233 10 OLT OLT NNP cord-010119-t1x9gknd 8233 11 ) ) -RRB- cord-010119-t1x9gknd 8233 12 is be VBZ cord-010119-t1x9gknd 8233 13 a a DT cord-010119-t1x9gknd 8233 14 complex complex JJ cord-010119-t1x9gknd 8233 15 and and CC cord-010119-t1x9gknd 8233 16 technically technically RB cord-010119-t1x9gknd 8233 17 challenging challenging JJ cord-010119-t1x9gknd 8233 18 procedure procedure NN cord-010119-t1x9gknd 8233 19 that that WDT cord-010119-t1x9gknd 8233 20 can can MD cord-010119-t1x9gknd 8233 21 be be VB cord-010119-t1x9gknd 8233 22 complicated complicate VBN cord-010119-t1x9gknd 8233 23 by by IN cord-010119-t1x9gknd 8233 24 severe severe JJ cord-010119-t1x9gknd 8233 25 intraoperative intraoperative JJ cord-010119-t1x9gknd 8233 26 bleeding bleeding NN cord-010119-t1x9gknd 8233 27 . . . cord-010119-t1x9gknd 8234 1 We -PRON- PRP cord-010119-t1x9gknd 8234 2 report report VBP cord-010119-t1x9gknd 8234 3 a a DT cord-010119-t1x9gknd 8234 4 case case NN cord-010119-t1x9gknd 8234 5 of of IN cord-010119-t1x9gknd 8234 6 massive massive JJ cord-010119-t1x9gknd 8234 7 transfusion transfusion NN cord-010119-t1x9gknd 8234 8 in in IN cord-010119-t1x9gknd 8234 9 an an DT cord-010119-t1x9gknd 8234 10 OLT OLT NNP cord-010119-t1x9gknd 8234 11 patient patient NN cord-010119-t1x9gknd 8234 12 necessitating necessitate VBG cord-010119-t1x9gknd 8234 13 an an DT cord-010119-t1x9gknd 8234 14 ABO ABO NNP cord-010119-t1x9gknd 8234 15 blood blood NN cord-010119-t1x9gknd 8234 16 group group NN cord-010119-t1x9gknd 8234 17 switch switch NN cord-010119-t1x9gknd 8234 18 ( ( -LRB- cord-010119-t1x9gknd 8234 19 from from IN cord-010119-t1x9gknd 8234 20 O1 o1 NN cord-010119-t1x9gknd 8234 21 to to IN cord-010119-t1x9gknd 8234 22 A1 a1 NN cord-010119-t1x9gknd 8234 23 ) ) -RRB- cord-010119-t1x9gknd 8234 24 to to TO cord-010119-t1x9gknd 8234 25 sustain sustain VB cord-010119-t1x9gknd 8234 26 transfusion transfusion NN cord-010119-t1x9gknd 8234 27 support support NN cord-010119-t1x9gknd 8234 28 and and CC cord-010119-t1x9gknd 8234 29 minimum minimum NN cord-010119-t1x9gknd 8234 30 group group NN cord-010119-t1x9gknd 8234 31 O O NNP cord-010119-t1x9gknd 8234 32 RBC RBC NNP cord-010119-t1x9gknd 8234 33 inventories inventory NNS cord-010119-t1x9gknd 8234 34 . . . cord-010119-t1x9gknd 8235 1 Study Study NNP cord-010119-t1x9gknd 8235 2 Design Design NNP cord-010119-t1x9gknd 8235 3 / / SYM cord-010119-t1x9gknd 8235 4 Methods method NNS cord-010119-t1x9gknd 8235 5 : : : cord-010119-t1x9gknd 8235 6 Type type NN cord-010119-t1x9gknd 8235 7 & & CC cord-010119-t1x9gknd 8235 8 screen screen NN cord-010119-t1x9gknd 8235 9 ( ( -LRB- cord-010119-t1x9gknd 8235 10 TS TS NNP cord-010119-t1x9gknd 8235 11 , , , cord-010119-t1x9gknd 8235 12 gel gel NN cord-010119-t1x9gknd 8235 13 ) ) -RRB- cord-010119-t1x9gknd 8235 14 and and CC cord-010119-t1x9gknd 8235 15 anti anti JJ cord-010119-t1x9gknd 8235 16 - - JJ cord-010119-t1x9gknd 8235 17 A a JJ cord-010119-t1x9gknd 8235 18 titers titer NNS cord-010119-t1x9gknd 8235 19 ( ( -LRB- cord-010119-t1x9gknd 8235 20 tube tube NN cord-010119-t1x9gknd 8235 21 ) ) -RRB- cord-010119-t1x9gknd 8235 22 were be VBD cord-010119-t1x9gknd 8235 23 performed perform VBN cord-010119-t1x9gknd 8235 24 using use VBG cord-010119-t1x9gknd 8235 25 routine routine JJ cord-010119-t1x9gknd 8235 26 methods method NNS cord-010119-t1x9gknd 8235 27 . . . cord-010119-t1x9gknd 8236 1 A a DT cord-010119-t1x9gknd 8236 2 chart chart NN cord-010119-t1x9gknd 8236 3 review review NN cord-010119-t1x9gknd 8236 4 was be VBD cord-010119-t1x9gknd 8236 5 performed perform VBN cord-010119-t1x9gknd 8236 6 for for IN cord-010119-t1x9gknd 8236 7 pertinent pertinent JJ cord-010119-t1x9gknd 8236 8 medical medical JJ cord-010119-t1x9gknd 8236 9 and and CC cord-010119-t1x9gknd 8236 10 laboratory laboratory NN cord-010119-t1x9gknd 8236 11 findings finding NNS cord-010119-t1x9gknd 8236 12 . . . cord-010119-t1x9gknd 8237 1 Results/ Results/ . cord-010119-t1x9gknd 8238 1 Findings finding NNS cord-010119-t1x9gknd 8238 2 : : : cord-010119-t1x9gknd 8239 1 The the DT cord-010119-t1x9gknd 8239 2 patient patient NN cord-010119-t1x9gknd 8239 3 was be VBD cord-010119-t1x9gknd 8239 4 a a DT cord-010119-t1x9gknd 8239 5 63-year 63-year JJ cord-010119-t1x9gknd 8239 6 - - HYPH cord-010119-t1x9gknd 8239 7 old old JJ cord-010119-t1x9gknd 8239 8 O1 o1 NN cord-010119-t1x9gknd 8239 9 man man NN cord-010119-t1x9gknd 8239 10 with with IN cord-010119-t1x9gknd 8239 11 cirrhosis cirrhosis NN cord-010119-t1x9gknd 8239 12 secondary secondary JJ cord-010119-t1x9gknd 8239 13 to to IN cord-010119-t1x9gknd 8239 14 nonalcoholic nonalcoholic JJ cord-010119-t1x9gknd 8239 15 steatohepatitis steatohepatitis NN cord-010119-t1x9gknd 8239 16 and and CC cord-010119-t1x9gknd 8239 17 alpha-1 alpha-1 NNP cord-010119-t1x9gknd 8239 18 antitrypsin antitrypsin NN cord-010119-t1x9gknd 8239 19 deficiency deficiency NN cord-010119-t1x9gknd 8239 20 who who WP cord-010119-t1x9gknd 8239 21 presented present VBD cord-010119-t1x9gknd 8239 22 for for IN cord-010119-t1x9gknd 8239 23 OLT OLT NNP cord-010119-t1x9gknd 8239 24 ( ( -LRB- cord-010119-t1x9gknd 8239 25 donor donor NN cord-010119-t1x9gknd 8239 26 O1 O1 NNP cord-010119-t1x9gknd 8239 27 ) ) -RRB- cord-010119-t1x9gknd 8239 28 . . . cord-010119-t1x9gknd 8240 1 During during IN cord-010119-t1x9gknd 8240 2 OLT OLT NNP cord-010119-t1x9gknd 8240 3 , , , cord-010119-t1x9gknd 8240 4 the the DT cord-010119-t1x9gknd 8240 5 patient patient NN cord-010119-t1x9gknd 8240 6 endured endure VBD cord-010119-t1x9gknd 8240 7 substantial substantial JJ cord-010119-t1x9gknd 8240 8 bleeding bleeding NN cord-010119-t1x9gknd 8240 9 from from IN cord-010119-t1x9gknd 8240 10 retroperitoneal retroperitoneal JJ cord-010119-t1x9gknd 8240 11 collateral collateral JJ cord-010119-t1x9gknd 8240 12 vessels vessel NNS cord-010119-t1x9gknd 8240 13 complicated complicate VBN cord-010119-t1x9gknd 8240 14 by by IN cord-010119-t1x9gknd 8240 15 post post JJ cord-010119-t1x9gknd 8240 16 - - JJ cord-010119-t1x9gknd 8240 17 transplant transplant JJ cord-010119-t1x9gknd 8240 18 coagulopathy coagulopathy NN cord-010119-t1x9gknd 8240 19 . . . cord-010119-t1x9gknd 8241 1 He -PRON- PRP cord-010119-t1x9gknd 8241 2 required require VBD cord-010119-t1x9gknd 8241 3 rapid rapid JJ cord-010119-t1x9gknd 8241 4 high high JJ cord-010119-t1x9gknd 8241 5 volume volume NN cord-010119-t1x9gknd 8241 6 RBC RBC NNP cord-010119-t1x9gknd 8241 7 and and CC cord-010119-t1x9gknd 8241 8 plasma plasma NN cord-010119-t1x9gknd 8241 9 support support NN cord-010119-t1x9gknd 8241 10 , , , cord-010119-t1x9gknd 8241 11 which which WDT cord-010119-t1x9gknd 8241 12 strained strain VBD cord-010119-t1x9gknd 8241 13 hospital hospital NN cord-010119-t1x9gknd 8241 14 inventories inventory NNS cord-010119-t1x9gknd 8241 15 . . . cord-010119-t1x9gknd 8242 1 After after IN cord-010119-t1x9gknd 8242 2 receiving receive VBG cord-010119-t1x9gknd 8242 3 46 46 CD cord-010119-t1x9gknd 8242 4 units unit NNS cord-010119-t1x9gknd 8242 5 of of IN cord-010119-t1x9gknd 8242 6 O1 o1 NN cord-010119-t1x9gknd 8242 7 RBCs rbc NNS cord-010119-t1x9gknd 8242 8 and and CC cord-010119-t1x9gknd 8242 9 26 26 CD cord-010119-t1x9gknd 8242 10 units unit NNS cord-010119-t1x9gknd 8242 11 of of IN cord-010119-t1x9gknd 8242 12 O1 o1 NN cord-010119-t1x9gknd 8242 13 plasma plasma NN cord-010119-t1x9gknd 8242 14 with with IN cord-010119-t1x9gknd 8242 15 ongoing ongoing JJ cord-010119-t1x9gknd 8242 16 severe severe JJ cord-010119-t1x9gknd 8242 17 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8242 18 , , , cord-010119-t1x9gknd 8242 19 he -PRON- PRP cord-010119-t1x9gknd 8242 20 was be VBD cord-010119-t1x9gknd 8242 21 switched switch VBN cord-010119-t1x9gknd 8242 22 to to IN cord-010119-t1x9gknd 8242 23 group group NN cord-010119-t1x9gknd 8242 24 A a DT cord-010119-t1x9gknd 8242 25 products product NNS cord-010119-t1x9gknd 8242 26 . . . cord-010119-t1x9gknd 8243 1 Ten ten CD cord-010119-t1x9gknd 8243 2 units unit NNS cord-010119-t1x9gknd 8243 3 of of IN cord-010119-t1x9gknd 8243 4 A1 a1 NN cord-010119-t1x9gknd 8243 5 plasma plasma NN cord-010119-t1x9gknd 8243 6 were be VBD cord-010119-t1x9gknd 8243 7 transfused transfuse VBN cord-010119-t1x9gknd 8243 8 to to TO cord-010119-t1x9gknd 8243 9 wash wash VB cord-010119-t1x9gknd 8243 10 out out RP cord-010119-t1x9gknd 8243 11 anti anti JJ cord-010119-t1x9gknd 8243 12 - - JJ cord-010119-t1x9gknd 8243 13 A a DT cord-010119-t1x9gknd 8243 14 antibody antibody NN cord-010119-t1x9gknd 8243 15 prior prior RB cord-010119-t1x9gknd 8243 16 to to IN cord-010119-t1x9gknd 8243 17 transfusion transfusion NN cord-010119-t1x9gknd 8243 18 of of IN cord-010119-t1x9gknd 8243 19 A1 A1 NNP cord-010119-t1x9gknd 8243 20 RBCs rbc NNS cord-010119-t1x9gknd 8243 21 . . . cord-010119-t1x9gknd 8244 1 Due due IN cord-010119-t1x9gknd 8244 2 to to IN cord-010119-t1x9gknd 8244 3 difficulty difficulty NN cord-010119-t1x9gknd 8244 4 controlling control VBG cord-010119-t1x9gknd 8244 5 the the DT cord-010119-t1x9gknd 8244 6 bleeding bleeding NN cord-010119-t1x9gknd 8244 7 , , , cord-010119-t1x9gknd 8244 8 biliary biliary JJ cord-010119-t1x9gknd 8244 9 reconstruction reconstruction NN cord-010119-t1x9gknd 8244 10 and and CC cord-010119-t1x9gknd 8244 11 fascial fascial JJ cord-010119-t1x9gknd 8244 12 closure closure NN cord-010119-t1x9gknd 8244 13 were be VBD cord-010119-t1x9gknd 8244 14 delayed delay VBN cord-010119-t1x9gknd 8244 15 for for IN cord-010119-t1x9gknd 8244 16 7 7 CD cord-010119-t1x9gknd 8244 17 hours hour NNS cord-010119-t1x9gknd 8244 18 post post NN cord-010119-t1x9gknd 8244 19 - - NN cord-010119-t1x9gknd 8244 20 transplant transplant NN cord-010119-t1x9gknd 8244 21 . . . cord-010119-t1x9gknd 8245 1 The the DT cord-010119-t1x9gknd 8245 2 patient patient NN cord-010119-t1x9gknd 8245 3 's 's POS cord-010119-t1x9gknd 8245 4 total total JJ cord-010119-t1x9gknd 8245 5 estimated estimated JJ cord-010119-t1x9gknd 8245 6 blood blood NN cord-010119-t1x9gknd 8245 7 loss loss NN cord-010119-t1x9gknd 8245 8 was be VBD cord-010119-t1x9gknd 8245 9 > > XX cord-010119-t1x9gknd 8246 1 20L. 20l. LS cord-010119-t1x9gknd 8247 1 He -PRON- PRP cord-010119-t1x9gknd 8247 2 received receive VBD cord-010119-t1x9gknd 8247 3 a a DT cord-010119-t1x9gknd 8247 4 total total NN cord-010119-t1x9gknd 8247 5 of of IN cord-010119-t1x9gknd 8247 6 71 71 CD cord-010119-t1x9gknd 8247 7 units unit NNS cord-010119-t1x9gknd 8247 8 of of IN cord-010119-t1x9gknd 8247 9 RBCs rbc NNS cord-010119-t1x9gknd 8247 10 ( ( -LRB- cord-010119-t1x9gknd 8247 11 including include VBG cord-010119-t1x9gknd 8247 12 23 23 CD cord-010119-t1x9gknd 8247 13 A1 A1 NNP cord-010119-t1x9gknd 8247 14 ) ) -RRB- cord-010119-t1x9gknd 8247 15 , , , cord-010119-t1x9gknd 8247 16 63 63 CD cord-010119-t1x9gknd 8247 17 units unit NNS cord-010119-t1x9gknd 8247 18 of of IN cord-010119-t1x9gknd 8247 19 plasma plasma NN cord-010119-t1x9gknd 8247 20 ( ( -LRB- cord-010119-t1x9gknd 8247 21 including include VBG cord-010119-t1x9gknd 8247 22 37 37 CD cord-010119-t1x9gknd 8247 23 A1 A1 NNP cord-010119-t1x9gknd 8247 24 ) ) -RRB- cord-010119-t1x9gknd 8247 25 , , , cord-010119-t1x9gknd 8247 26 6 6 CD cord-010119-t1x9gknd 8247 27 units unit NNS cord-010119-t1x9gknd 8247 28 of of IN cord-010119-t1x9gknd 8247 29 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8247 30 , , , cord-010119-t1x9gknd 8247 31 and and CC cord-010119-t1x9gknd 8247 32 9 9 CD cord-010119-t1x9gknd 8247 33 units unit NNS cord-010119-t1x9gknd 8247 34 of of IN cord-010119-t1x9gknd 8247 35 platelets platelet NNS cord-010119-t1x9gknd 8247 36 . . . cord-010119-t1x9gknd 8248 1 Towards towards IN cord-010119-t1x9gknd 8248 2 the the DT cord-010119-t1x9gknd 8248 3 end end NN cord-010119-t1x9gknd 8248 4 of of IN cord-010119-t1x9gknd 8248 5 the the DT cord-010119-t1x9gknd 8248 6 second second JJ cord-010119-t1x9gknd 8248 7 procedure procedure NN cord-010119-t1x9gknd 8248 8 , , , cord-010119-t1x9gknd 8248 9 the the DT cord-010119-t1x9gknd 8248 10 patient patient NN cord-010119-t1x9gknd 8248 11 's 's POS cord-010119-t1x9gknd 8248 12 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8248 13 was be VBD cord-010119-t1x9gknd 8248 14 stabilized stabilize VBN cord-010119-t1x9gknd 8248 15 and and CC cord-010119-t1x9gknd 8248 16 the the DT cord-010119-t1x9gknd 8248 17 final final JJ cord-010119-t1x9gknd 8248 18 two two CD cord-010119-t1x9gknd 8248 19 RBC RBC NNP cord-010119-t1x9gknd 8248 20 units unit NNS cord-010119-t1x9gknd 8248 21 he -PRON- PRP cord-010119-t1x9gknd 8248 22 received receive VBD cord-010119-t1x9gknd 8248 23 were be VBD cord-010119-t1x9gknd 8248 24 O1 o1 NN cord-010119-t1x9gknd 8248 25 . . . cord-010119-t1x9gknd 8249 1 On on IN cord-010119-t1x9gknd 8249 2 postoperative postoperative JJ cord-010119-t1x9gknd 8249 3 day day NN cord-010119-t1x9gknd 8249 4 ( ( -LRB- cord-010119-t1x9gknd 8249 5 POD POD NNP cord-010119-t1x9gknd 8249 6 ) ) -RRB- cord-010119-t1x9gknd 8249 7 1 1 CD cord-010119-t1x9gknd 8249 8 , , , cord-010119-t1x9gknd 8249 9 a a DT cord-010119-t1x9gknd 8249 10 TS TS NNP cord-010119-t1x9gknd 8249 11 showed show VBD cord-010119-t1x9gknd 8249 12 predominantly predominantly RB cord-010119-t1x9gknd 8249 13 A1 A1 NNP cord-010119-t1x9gknd 8249 14 RBCs rbc NNS cord-010119-t1x9gknd 8249 15 with with IN cord-010119-t1x9gknd 8249 16 trace trace NN cord-010119-t1x9gknd 8249 17 O1 o1 NN cord-010119-t1x9gknd 8249 18 RBCs rbc NNS cord-010119-t1x9gknd 8249 19 , , , cord-010119-t1x9gknd 8249 20 as as RB cord-010119-t1x9gknd 8249 21 well well RB cord-010119-t1x9gknd 8249 22 as as IN cord-010119-t1x9gknd 8249 23 very very RB cord-010119-t1x9gknd 8249 24 low low JJ cord-010119-t1x9gknd 8249 25 anti anti AFX cord-010119-t1x9gknd 8249 26 - - JJ cord-010119-t1x9gknd 8249 27 A a JJ cord-010119-t1x9gknd 8249 28 IgM igm NN cord-010119-t1x9gknd 8249 29 and and CC cord-010119-t1x9gknd 8249 30 IgG igg NN cord-010119-t1x9gknd 8249 31 titers titer NNS cord-010119-t1x9gknd 8249 32 ( ( -LRB- cord-010119-t1x9gknd 8249 33 Table Table NNP cord-010119-t1x9gknd 8249 34 1 1 CD cord-010119-t1x9gknd 8249 35 ) ) -RRB- cord-010119-t1x9gknd 8249 36 . . . cord-010119-t1x9gknd 8250 1 He -PRON- PRP cord-010119-t1x9gknd 8250 2 received receive VBD cord-010119-t1x9gknd 8250 3 two two CD cord-010119-t1x9gknd 8250 4 additional additional JJ cord-010119-t1x9gknd 8250 5 O1 O1 NNP cord-010119-t1x9gknd 8250 6 RBC RBC NNP cord-010119-t1x9gknd 8250 7 units unit NNS cord-010119-t1x9gknd 8250 8 ( ( -LRB- cord-010119-t1x9gknd 8250 9 1 1 CD cord-010119-t1x9gknd 8250 10 each each DT cord-010119-t1x9gknd 8250 11 on on IN cord-010119-t1x9gknd 8250 12 POD POD NNP cord-010119-t1x9gknd 8250 13 4 4 CD cord-010119-t1x9gknd 8250 14 and and CC cord-010119-t1x9gknd 8250 15 POD POD NNP cord-010119-t1x9gknd 8250 16 12 12 CD cord-010119-t1x9gknd 8250 17 ) ) -RRB- cord-010119-t1x9gknd 8250 18 with with IN cord-010119-t1x9gknd 8250 19 increasing increase VBG cord-010119-t1x9gknd 8250 20 O1 o1 NN cord-010119-t1x9gknd 8250 21 RBCs rbc NNS cord-010119-t1x9gknd 8250 22 on on IN cord-010119-t1x9gknd 8250 23 TS TS NNP cord-010119-t1x9gknd 8250 24 and and CC cord-010119-t1x9gknd 8250 25 rising rise VBG cord-010119-t1x9gknd 8250 26 anti anti JJ cord-010119-t1x9gknd 8250 27 - - JJ cord-010119-t1x9gknd 8250 28 A a JJ cord-010119-t1x9gknd 8250 29 titers titer NNS cord-010119-t1x9gknd 8250 30 . . . cord-010119-t1x9gknd 8251 1 His -PRON- PRP$ cord-010119-t1x9gknd 8251 2 blood blood NN cord-010119-t1x9gknd 8251 3 type type NN cord-010119-t1x9gknd 8251 4 was be VBD cord-010119-t1x9gknd 8251 5 unequivocally unequivocally RB cord-010119-t1x9gknd 8251 6 O1 o1 NN cord-010119-t1x9gknd 8251 7 by by IN cord-010119-t1x9gknd 8251 8 POD POD NNP cord-010119-t1x9gknd 8251 9 13 13 CD cord-010119-t1x9gknd 8251 10 . . . cord-010119-t1x9gknd 8252 1 The the DT cord-010119-t1x9gknd 8252 2 patient patient NN cord-010119-t1x9gknd 8252 3 showed show VBD cord-010119-t1x9gknd 8252 4 recovery recovery NN cord-010119-t1x9gknd 8252 5 of of IN cord-010119-t1x9gknd 8252 6 liver liver NN cord-010119-t1x9gknd 8252 7 synthetic synthetic JJ cord-010119-t1x9gknd 8252 8 function function NN cord-010119-t1x9gknd 8252 9 on on IN cord-010119-t1x9gknd 8252 10 POD pod NN cord-010119-t1x9gknd 8252 11 1 1 CD cord-010119-t1x9gknd 8252 12 ( ( -LRB- cord-010119-t1x9gknd 8252 13 Factor factor NN cord-010119-t1x9gknd 8252 14 5 5 CD cord-010119-t1x9gknd 8252 15 activity activity NN cord-010119-t1x9gknd 8252 16 5 5 CD cord-010119-t1x9gknd 8252 17 58 58 CD cord-010119-t1x9gknd 8252 18 % % NN cord-010119-t1x9gknd 8252 19 ) ) -RRB- cord-010119-t1x9gknd 8252 20 complicated complicate VBN cord-010119-t1x9gknd 8252 21 by by IN cord-010119-t1x9gknd 8252 22 cholestasis cholestasis NN cord-010119-t1x9gknd 8252 23 . . . cord-010119-t1x9gknd 8253 1 Conclusion conclusion NN cord-010119-t1x9gknd 8253 2 : : : cord-010119-t1x9gknd 8254 1 This this DT cord-010119-t1x9gknd 8254 2 study study NN cord-010119-t1x9gknd 8254 3 shows show VBZ cord-010119-t1x9gknd 8254 4 successful successful JJ cord-010119-t1x9gknd 8254 5 switching switching NN cord-010119-t1x9gknd 8254 6 of of IN cord-010119-t1x9gknd 8254 7 a a DT cord-010119-t1x9gknd 8254 8 group group NN cord-010119-t1x9gknd 8254 9 O o NN cord-010119-t1x9gknd 8254 10 patient patient JJ cord-010119-t1x9gknd 8254 11 to to TO cord-010119-t1x9gknd 8254 12 group group NN cord-010119-t1x9gknd 8254 13 A a NN cord-010119-t1x9gknd 8254 14 in in IN cord-010119-t1x9gknd 8254 15 the the DT cord-010119-t1x9gknd 8254 16 setting setting NN cord-010119-t1x9gknd 8254 17 of of IN cord-010119-t1x9gknd 8254 18 rapid rapid JJ cord-010119-t1x9gknd 8254 19 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8254 20 and and CC cord-010119-t1x9gknd 8254 21 massive massive JJ cord-010119-t1x9gknd 8254 22 transfusion transfusion NN cord-010119-t1x9gknd 8254 23 . . . cord-010119-t1x9gknd 8255 1 By by IN cord-010119-t1x9gknd 8255 2 POD POD NNP cord-010119-t1x9gknd 8255 3 13 13 CD cord-010119-t1x9gknd 8255 4 , , , cord-010119-t1x9gknd 8255 5 the the DT cord-010119-t1x9gknd 8255 6 patient patient NN cord-010119-t1x9gknd 8255 7 had have VBD cord-010119-t1x9gknd 8255 8 reverted revert VBN cord-010119-t1x9gknd 8255 9 to to IN cord-010119-t1x9gknd 8255 10 O1 o1 NN cord-010119-t1x9gknd 8255 11 with with IN cord-010119-t1x9gknd 8255 12 recovery recovery NN cord-010119-t1x9gknd 8255 13 of of IN cord-010119-t1x9gknd 8255 14 anti anti JJ cord-010119-t1x9gknd 8255 15 - - JJ cord-010119-t1x9gknd 8255 16 A a JJ cord-010119-t1x9gknd 8255 17 titers titer NNS cord-010119-t1x9gknd 8255 18 . . . cord-010119-t1x9gknd 8256 1 At at IN cord-010119-t1x9gknd 8256 2 3 3 CD cord-010119-t1x9gknd 8256 3 months month NNS cord-010119-t1x9gknd 8256 4 post post NN cord-010119-t1x9gknd 8256 5 - - JJ cord-010119-t1x9gknd 8256 6 OLT OLT NNP cord-010119-t1x9gknd 8256 7 , , , cord-010119-t1x9gknd 8256 8 the the DT cord-010119-t1x9gknd 8256 9 patient patient NN cord-010119-t1x9gknd 8256 10 is be VBZ cord-010119-t1x9gknd 8256 11 alive alive JJ cord-010119-t1x9gknd 8256 12 with with IN cord-010119-t1x9gknd 8256 13 signs sign NNS cord-010119-t1x9gknd 8256 14 of of IN cord-010119-t1x9gknd 8256 15 improving improve VBG cord-010119-t1x9gknd 8256 16 biliary biliary JJ cord-010119-t1x9gknd 8256 17 graft graft NN cord-010119-t1x9gknd 8256 18 function function NN cord-010119-t1x9gknd 8256 19 . . . cord-010119-t1x9gknd 8257 1 A a DT cord-010119-t1x9gknd 8257 2 New New NNP cord-010119-t1x9gknd 8257 3 RFID RFID NNP cord-010119-t1x9gknd 8257 4 Transfusion Transfusion NNP cord-010119-t1x9gknd 8257 5 Safety Safety NNP cord-010119-t1x9gknd 8257 6 System System NNP cord-010119-t1x9gknd 8257 7 Anna Anna NNP cord-010119-t1x9gknd 8257 8 Millan Millan NNP cord-010119-t1x9gknd 8257 9 * * NFP cord-010119-t1x9gknd 8258 1 1 1 CD cord-010119-t1x9gknd 8258 2 , , , cord-010119-t1x9gknd 8258 3 Alfred Alfred NNP cord-010119-t1x9gknd 8258 4 Mingo Mingo NNP cord-010119-t1x9gknd 8258 5 1 1 CD cord-010119-t1x9gknd 8259 1 , , , cord-010119-t1x9gknd 8259 2 Maria Maria NNP cord-010119-t1x9gknd 8259 3 Isabel Isabel NNP cord-010119-t1x9gknd 8259 4 Gonzalez Gonzalez NNP cord-010119-t1x9gknd 8259 5 1 1 CD cord-010119-t1x9gknd 8259 6 , , , cord-010119-t1x9gknd 8259 7 Antoni Antoni NNP cord-010119-t1x9gknd 8259 8 Mena Mena NNP cord-010119-t1x9gknd 8259 9 2 2 CD cord-010119-t1x9gknd 8259 10 and and CC cord-010119-t1x9gknd 8259 11 Juan Juan NNP cord-010119-t1x9gknd 8259 12 Pedro Pedro NNP cord-010119-t1x9gknd 8259 13 Benitez Benitez NNP cord-010119-t1x9gknd 8259 14 2 2 CD cord-010119-t1x9gknd 8259 15 . . . cord-010119-t1x9gknd 8259 16 1 1 CD cord-010119-t1x9gknd 8259 17 BST bst NN cord-010119-t1x9gknd 8259 18 , , , cord-010119-t1x9gknd 8260 1 2 2 CD cord-010119-t1x9gknd 8260 2 AT AT NNP cord-010119-t1x9gknd 8260 3 - - HYPH cord-010119-t1x9gknd 8260 4 Biotech Biotech NNP cord-010119-t1x9gknd 8260 5 Background Background NNP cord-010119-t1x9gknd 8260 6 / / SYM cord-010119-t1x9gknd 8260 7 Case Case NNP cord-010119-t1x9gknd 8260 8 Studies Studies NNPS cord-010119-t1x9gknd 8260 9 : : : cord-010119-t1x9gknd 8260 10 A a DT cord-010119-t1x9gknd 8260 11 new new JJ cord-010119-t1x9gknd 8260 12 Transfusion Transfusion NNP cord-010119-t1x9gknd 8260 13 Safety Safety NNP cord-010119-t1x9gknd 8260 14 System System NNP cord-010119-t1x9gknd 8260 15 ( ( -LRB- cord-010119-t1x9gknd 8260 16 TSS TSS NNP cord-010119-t1x9gknd 8260 17 ) ) -RRB- cord-010119-t1x9gknd 8260 18 , , , cord-010119-t1x9gknd 8260 19 based base VBN cord-010119-t1x9gknd 8260 20 on on IN cord-010119-t1x9gknd 8260 21 processes process NNS cord-010119-t1x9gknd 8260 22 and and CC cord-010119-t1x9gknd 8260 23 technologies technology NNS cord-010119-t1x9gknd 8260 24 , , , cord-010119-t1x9gknd 8260 25 especially especially RB cord-010119-t1x9gknd 8260 26 , , , cord-010119-t1x9gknd 8260 27 identification identification NN cord-010119-t1x9gknd 8260 28 by by IN cord-010119-t1x9gknd 8260 29 radio radio NN cord-010119-t1x9gknd 8260 30 frequency frequency NN cord-010119-t1x9gknd 8260 31 ( ( -LRB- cord-010119-t1x9gknd 8260 32 RFID RFID NNP cord-010119-t1x9gknd 8260 33 ) ) -RRB- cord-010119-t1x9gknd 8260 34 , , , cord-010119-t1x9gknd 8260 35 is be VBZ cord-010119-t1x9gknd 8260 36 currently currently RB cord-010119-t1x9gknd 8260 37 implemented implement VBN cord-010119-t1x9gknd 8260 38 in in IN cord-010119-t1x9gknd 8260 39 two two CD cord-010119-t1x9gknd 8260 40 hospitals hospital NNS cord-010119-t1x9gknd 8260 41 , , , cord-010119-t1x9gknd 8260 42 a a DT cord-010119-t1x9gknd 8260 43 general general JJ cord-010119-t1x9gknd 8260 44 one one NN cord-010119-t1x9gknd 8260 45 ( ( -LRB- cord-010119-t1x9gknd 8260 46 H1 H1 NNP cord-010119-t1x9gknd 8260 47 ) ) -RRB- cord-010119-t1x9gknd 8260 48 and and CC cord-010119-t1x9gknd 8260 49 an an DT cord-010119-t1x9gknd 8260 50 Oncology Oncology NNP cord-010119-t1x9gknd 8260 51 center center NN cord-010119-t1x9gknd 8260 52 ( ( -LRB- cord-010119-t1x9gknd 8260 53 H2 H2 NNP cord-010119-t1x9gknd 8260 54 ) ) -RRB- cord-010119-t1x9gknd 8260 55 . . . cord-010119-t1x9gknd 8261 1 The the DT cord-010119-t1x9gknd 8261 2 TSS TSS NNP cord-010119-t1x9gknd 8261 3 is be VBZ cord-010119-t1x9gknd 8261 4 fully fully RB cord-010119-t1x9gknd 8261 5 effective effective JJ cord-010119-t1x9gknd 8261 6 in in IN cord-010119-t1x9gknd 8261 7 protecting protect VBG cord-010119-t1x9gknd 8261 8 against against IN cord-010119-t1x9gknd 8261 9 incidents incident NNS cord-010119-t1x9gknd 8261 10 , , , cord-010119-t1x9gknd 8261 11 and and CC cord-010119-t1x9gknd 8261 12 specifically specifically RB cord-010119-t1x9gknd 8261 13 offers offer VBZ cord-010119-t1x9gknd 8261 14 mechanisms mechanism NNS cord-010119-t1x9gknd 8261 15 to to TO cord-010119-t1x9gknd 8261 16 detect detect VB cord-010119-t1x9gknd 8261 17 near near JJ cord-010119-t1x9gknd 8261 18 misses miss NNS cord-010119-t1x9gknd 8261 19 ( ( -LRB- cord-010119-t1x9gknd 8261 20 NM NM NNP cord-010119-t1x9gknd 8261 21 ) ) -RRB- cord-010119-t1x9gknd 8261 22 by by IN cord-010119-t1x9gknd 8261 23 using use VBG cord-010119-t1x9gknd 8261 24 procedural procedural JJ cord-010119-t1x9gknd 8261 25 and and CC cord-010119-t1x9gknd 8261 26 physical physical JJ cord-010119-t1x9gknd 8261 27 barriers barrier NNS cord-010119-t1x9gknd 8261 28 , , , cord-010119-t1x9gknd 8261 29 assuring assure VBG cord-010119-t1x9gknd 8261 30 that that IN cord-010119-t1x9gknd 8261 31 the the DT cord-010119-t1x9gknd 8261 32 pretransfusional pretransfusional JJ cord-010119-t1x9gknd 8261 33 sample sample NN cord-010119-t1x9gknd 8261 34 extraction extraction NN cord-010119-t1x9gknd 8261 35 ( ( -LRB- cord-010119-t1x9gknd 8261 36 PSE PSE NNP cord-010119-t1x9gknd 8261 37 ) ) -RRB- cord-010119-t1x9gknd 8261 38 and and CC cord-010119-t1x9gknd 8261 39 the the DT cord-010119-t1x9gknd 8261 40 blood blood NN cord-010119-t1x9gknd 8261 41 components component NNS cord-010119-t1x9gknd 8261 42 administration administration NN cord-010119-t1x9gknd 8261 43 ( ( -LRB- cord-010119-t1x9gknd 8261 44 BCA BCA NNP cord-010119-t1x9gknd 8261 45 ) ) -RRB- cord-010119-t1x9gknd 8261 46 only only RB cord-010119-t1x9gknd 8261 47 take take VBP cord-010119-t1x9gknd 8261 48 place place NN cord-010119-t1x9gknd 8261 49 at at IN cord-010119-t1x9gknd 8261 50 bed bed NN cord-010119-t1x9gknd 8261 51 side side NN cord-010119-t1x9gknd 8261 52 , , , cord-010119-t1x9gknd 8261 53 using use VBG cord-010119-t1x9gknd 8261 54 a a DT cord-010119-t1x9gknd 8261 55 location location NN cord-010119-t1x9gknd 8261 56 control control NN cord-010119-t1x9gknd 8261 57 and and CC cord-010119-t1x9gknd 8261 58 interacting interact VBG cord-010119-t1x9gknd 8261 59 with with IN cord-010119-t1x9gknd 8261 60 the the DT cord-010119-t1x9gknd 8261 61 clinical clinical JJ cord-010119-t1x9gknd 8261 62 and and CC cord-010119-t1x9gknd 8261 63 transfusion transfusion NN cord-010119-t1x9gknd 8261 64 information information NN cord-010119-t1x9gknd 8261 65 systems system NNS cord-010119-t1x9gknd 8261 66 ( ( -LRB- cord-010119-t1x9gknd 8261 67 TIS TIS NNP cord-010119-t1x9gknd 8261 68 ) ) -RRB- cord-010119-t1x9gknd 8261 69 . . . cord-010119-t1x9gknd 8262 1 The the DT cord-010119-t1x9gknd 8262 2 TSS TSS NNP cord-010119-t1x9gknd 8262 3 allows allow VBZ cord-010119-t1x9gknd 8262 4 to to TO cord-010119-t1x9gknd 8262 5 analyze analyze VB cord-010119-t1x9gknd 8262 6 the the DT cord-010119-t1x9gknd 8262 7 transfusional transfusional JJ cord-010119-t1x9gknd 8262 8 activity activity NN cord-010119-t1x9gknd 8262 9 information information NN cord-010119-t1x9gknd 8262 10 in in IN cord-010119-t1x9gknd 8262 11 real real JJ cord-010119-t1x9gknd 8262 12 time time NN cord-010119-t1x9gknd 8262 13 to to TO cord-010119-t1x9gknd 8262 14 project project VB cord-010119-t1x9gknd 8262 15 organizational organizational JJ cord-010119-t1x9gknd 8262 16 changes change NNS cord-010119-t1x9gknd 8262 17 in in IN cord-010119-t1x9gknd 8262 18 both both DT cord-010119-t1x9gknd 8262 19 transfusion transfusion NN cord-010119-t1x9gknd 8262 20 services service NNS cord-010119-t1x9gknd 8262 21 and and CC cord-010119-t1x9gknd 8262 22 hospital hospital NN cord-010119-t1x9gknd 8262 23 units unit NNS cord-010119-t1x9gknd 8262 24 , , , cord-010119-t1x9gknd 8262 25 and and CC cord-010119-t1x9gknd 8262 26 to to TO cord-010119-t1x9gknd 8262 27 create create VB cord-010119-t1x9gknd 8262 28 a a DT cord-010119-t1x9gknd 8262 29 new new JJ cord-010119-t1x9gknd 8262 30 classification classification NN cord-010119-t1x9gknd 8262 31 of of IN cord-010119-t1x9gknd 8262 32 NM NM NNP cord-010119-t1x9gknd 8262 33 . . . cord-010119-t1x9gknd 8263 1 Study Study NNP cord-010119-t1x9gknd 8263 2 Design Design NNP cord-010119-t1x9gknd 8263 3 / / SYM cord-010119-t1x9gknd 8263 4 Method method NN cord-010119-t1x9gknd 8263 5 : : : cord-010119-t1x9gknd 8264 1 Retrospective retrospective JJ cord-010119-t1x9gknd 8264 2 analysis analysis NN cord-010119-t1x9gknd 8264 3 of of IN cord-010119-t1x9gknd 8264 4 2016 2016 CD cord-010119-t1x9gknd 8264 5 transfusion transfusion NN cord-010119-t1x9gknd 8264 6 activity activity NN cord-010119-t1x9gknd 8264 7 in in IN cord-010119-t1x9gknd 8264 8 both both DT cord-010119-t1x9gknd 8264 9 H1 H1 NNP cord-010119-t1x9gknd 8264 10 and and CC cord-010119-t1x9gknd 8264 11 H2 H2 NNP cord-010119-t1x9gknd 8264 12 shows show VBZ cord-010119-t1x9gknd 8264 13 7970 7970 CD cord-010119-t1x9gknd 8264 14 PSE PSE NNP cord-010119-t1x9gknd 8264 15 and and CC cord-010119-t1x9gknd 8264 16 12572 12572 CD cord-010119-t1x9gknd 8264 17 BCA BCA NNP cord-010119-t1x9gknd 8264 18 , , , cord-010119-t1x9gknd 8264 19 out out IN cord-010119-t1x9gknd 8264 20 of of IN cord-010119-t1x9gknd 8264 21 13163 13163 CD cord-010119-t1x9gknd 8264 22 and and CC cord-010119-t1x9gknd 8264 23 20676 20676 CD cord-010119-t1x9gknd 8264 24 respectively respectively RB cord-010119-t1x9gknd 8264 25 , , , cord-010119-t1x9gknd 8264 26 since since IN cord-010119-t1x9gknd 8264 27 the the DT cord-010119-t1x9gknd 8264 28 TSS TSS NNP cord-010119-t1x9gknd 8264 29 deployment deployment NN cord-010119-t1x9gknd 8264 30 in in IN cord-010119-t1x9gknd 8264 31 2015 2015 CD cord-010119-t1x9gknd 8264 32 . . . cord-010119-t1x9gknd 8265 1 Retrospective retrospective JJ cord-010119-t1x9gknd 8265 2 analysis analysis NN cord-010119-t1x9gknd 8265 3 and and CC cord-010119-t1x9gknd 8265 4 classification classification NN cord-010119-t1x9gknd 8265 5 of of IN cord-010119-t1x9gknd 8265 6 6700 6700 CD cord-010119-t1x9gknd 8265 7 security security NN cord-010119-t1x9gknd 8265 8 events event NNS cord-010119-t1x9gknd 8265 9 has have VBZ cord-010119-t1x9gknd 8265 10 been be VBN cord-010119-t1x9gknd 8265 11 done do VBN cord-010119-t1x9gknd 8265 12 . . . cord-010119-t1x9gknd 8266 1 Results/ Results/ . cord-010119-t1x9gknd 8267 1 Finding finding NN cord-010119-t1x9gknd 8267 2 : : : cord-010119-t1x9gknd 8268 1 Activity activity NN cord-010119-t1x9gknd 8268 2 results result NNS cord-010119-t1x9gknd 8268 3 for for IN cord-010119-t1x9gknd 8268 4 both both DT cord-010119-t1x9gknd 8268 5 hospitals hospital NNS cord-010119-t1x9gknd 8268 6 are be VBP cord-010119-t1x9gknd 8268 7 shown show VBN cord-010119-t1x9gknd 8268 8 in in IN cord-010119-t1x9gknd 8268 9 the the DT cord-010119-t1x9gknd 8268 10 table table NN cord-010119-t1x9gknd 8268 11 below below RB cord-010119-t1x9gknd 8268 12 . . . cord-010119-t1x9gknd 8269 1 The the DT cord-010119-t1x9gknd 8269 2 safety safety NN cord-010119-t1x9gknd 8269 3 events event NNS cord-010119-t1x9gknd 8269 4 have have VBP cord-010119-t1x9gknd 8269 5 been be VBN cord-010119-t1x9gknd 8269 6 classified classify VBN cord-010119-t1x9gknd 8269 7 in in IN cord-010119-t1x9gknd 8269 8 pretransfusion pretransfusion NN cord-010119-t1x9gknd 8269 9 sample sample NN cord-010119-t1x9gknd 8269 10 extraction extraction NN cord-010119-t1x9gknd 8269 11 ( ( -LRB- cord-010119-t1x9gknd 8269 12 PSE PSE NNP cord-010119-t1x9gknd 8269 13 ) ) -RRB- cord-010119-t1x9gknd 8269 14 , , , cord-010119-t1x9gknd 8269 15 blood blood NN cord-010119-t1x9gknd 8269 16 component component NN cord-010119-t1x9gknd 8269 17 assignment assignment NN cord-010119-t1x9gknd 8269 18 ( ( -LRB- cord-010119-t1x9gknd 8269 19 BCAS BCAS NNP cord-010119-t1x9gknd 8269 20 ) ) -RRB- cord-010119-t1x9gknd 8269 21 in in IN cord-010119-t1x9gknd 8269 22 the the DT cord-010119-t1x9gknd 8269 23 transfusion transfusion NN cord-010119-t1x9gknd 8269 24 service service NN cord-010119-t1x9gknd 8269 25 and and CC cord-010119-t1x9gknd 8269 26 blood blood NN cord-010119-t1x9gknd 8269 27 component component NN cord-010119-t1x9gknd 8269 28 administration administration NN cord-010119-t1x9gknd 8269 29 ( ( -LRB- cord-010119-t1x9gknd 8269 30 BCA BCA NNP cord-010119-t1x9gknd 8269 31 ) ) -RRB- cord-010119-t1x9gknd 8269 32 near near IN cord-010119-t1x9gknd 8269 33 misses miss NNS cord-010119-t1x9gknd 8269 34 ( ( -LRB- cord-010119-t1x9gknd 8269 35 NM NM NNP cord-010119-t1x9gknd 8269 36 ) ) -RRB- cord-010119-t1x9gknd 8269 37 . . . cord-010119-t1x9gknd 8270 1 For for IN cord-010119-t1x9gknd 8270 2 H1 H1 NNP cord-010119-t1x9gknd 8270 3 , , , cord-010119-t1x9gknd 8270 4 NM NM NNP cord-010119-t1x9gknd 8270 5 related relate VBD cord-010119-t1x9gknd 8270 6 to to IN cord-010119-t1x9gknd 8270 7 PSE PSE NNP cord-010119-t1x9gknd 8270 8 accounted account VBD cord-010119-t1x9gknd 8270 9 for for IN cord-010119-t1x9gknd 8270 10 42.39 42.39 CD cord-010119-t1x9gknd 8270 11 % % NN cord-010119-t1x9gknd 8270 12 of of IN cord-010119-t1x9gknd 8270 13 all all DT cord-010119-t1x9gknd 8270 14 , , , cord-010119-t1x9gknd 8270 15 being be VBG cord-010119-t1x9gknd 8270 16 the the DT cord-010119-t1x9gknd 8270 17 mistake mistake NN cord-010119-t1x9gknd 8270 18 in in IN cord-010119-t1x9gknd 8270 19 concordance concordance NN cord-010119-t1x9gknd 8270 20 between between IN cord-010119-t1x9gknd 8270 21 patient patient JJ cord-010119-t1x9gknd 8270 22 identification identification NN cord-010119-t1x9gknd 8270 23 and and CC cord-010119-t1x9gknd 8270 24 prescription prescription NN cord-010119-t1x9gknd 8270 25 order order NN cord-010119-t1x9gknd 8270 26 the the DT cord-010119-t1x9gknd 8270 27 most most RBS cord-010119-t1x9gknd 8270 28 frequent frequent JJ cord-010119-t1x9gknd 8270 29 ( ( -LRB- cord-010119-t1x9gknd 8270 30 52.03 52.03 CD cord-010119-t1x9gknd 8270 31 % % NN cord-010119-t1x9gknd 8270 32 ) ) -RRB- cord-010119-t1x9gknd 8270 33 . . . cord-010119-t1x9gknd 8271 1 The the DT cord-010119-t1x9gknd 8271 2 NM NM NNP cord-010119-t1x9gknd 8271 3 detected detect VBD cord-010119-t1x9gknd 8271 4 in in IN cord-010119-t1x9gknd 8271 5 BCAS BCAS NNP cord-010119-t1x9gknd 8271 6 were be VBD cord-010119-t1x9gknd 8271 7 12.1 12.1 CD cord-010119-t1x9gknd 8271 8 % % NN cord-010119-t1x9gknd 8271 9 of of IN cord-010119-t1x9gknd 8271 10 all all DT cord-010119-t1x9gknd 8271 11 and and CC cord-010119-t1x9gknd 8271 12 mostly mostly RB cord-010119-t1x9gknd 8271 13 ( ( -LRB- cord-010119-t1x9gknd 8271 14 74.52 74.52 CD cord-010119-t1x9gknd 8271 15 % % NN cord-010119-t1x9gknd 8271 16 ) ) -RRB- cord-010119-t1x9gknd 8271 17 occur occur VBP cord-010119-t1x9gknd 8271 18 when when WRB cord-010119-t1x9gknd 8271 19 the the DT cord-010119-t1x9gknd 8271 20 patient patient JJ cord-010119-t1x9gknd 8271 21 information information NN cord-010119-t1x9gknd 8271 22 in in IN cord-010119-t1x9gknd 8271 23 the the DT cord-010119-t1x9gknd 8271 24 TIS TIS NNP cord-010119-t1x9gknd 8271 25 does do VBZ cord-010119-t1x9gknd 8271 26 not not RB cord-010119-t1x9gknd 8271 27 match match VB cord-010119-t1x9gknd 8271 28 the the DT cord-010119-t1x9gknd 8271 29 one one CD cord-010119-t1x9gknd 8271 30 registered register VBN cord-010119-t1x9gknd 8271 31 in in IN cord-010119-t1x9gknd 8271 32 the the DT cord-010119-t1x9gknd 8271 33 TSS TSS NNP cord-010119-t1x9gknd 8271 34 . . . cord-010119-t1x9gknd 8272 1 The the DT cord-010119-t1x9gknd 8272 2 NM NM NNP cord-010119-t1x9gknd 8272 3 detected detect VBD cord-010119-t1x9gknd 8272 4 in in IN cord-010119-t1x9gknd 8272 5 BCA BCA NNP cord-010119-t1x9gknd 8272 6 are be VBP cord-010119-t1x9gknd 8272 7 45.51 45.51 CD cord-010119-t1x9gknd 8272 8 % % NN cord-010119-t1x9gknd 8272 9 of of IN cord-010119-t1x9gknd 8272 10 all all DT cord-010119-t1x9gknd 8272 11 and and CC cord-010119-t1x9gknd 8272 12 mostly mostly RB cord-010119-t1x9gknd 8272 13 ( ( -LRB- cord-010119-t1x9gknd 8272 14 36 36 CD cord-010119-t1x9gknd 8272 15 % % NN cord-010119-t1x9gknd 8272 16 ) ) -RRB- cord-010119-t1x9gknd 8273 1 the the DT cord-010119-t1x9gknd 8273 2 systems system NNS cord-010119-t1x9gknd 8273 3 detects detect VBZ cord-010119-t1x9gknd 8273 4 a a DT cord-010119-t1x9gknd 8273 5 not not RB cord-010119-t1x9gknd 8273 6 assigned assign VBN cord-010119-t1x9gknd 8273 7 bracelet bracelet NN cord-010119-t1x9gknd 8273 8 . . . cord-010119-t1x9gknd 8274 1 For for IN cord-010119-t1x9gknd 8274 2 H2 H2 NNP cord-010119-t1x9gknd 8274 3 , , , cord-010119-t1x9gknd 8274 4 NM NM NNP cord-010119-t1x9gknd 8274 5 related relate VBD cord-010119-t1x9gknd 8274 6 to to IN cord-010119-t1x9gknd 8274 7 PSE PSE NNP cord-010119-t1x9gknd 8274 8 accounted account VBD cord-010119-t1x9gknd 8274 9 for for IN cord-010119-t1x9gknd 8274 10 the the DT cord-010119-t1x9gknd 8274 11 47.49 47.49 CD cord-010119-t1x9gknd 8274 12 % % NN cord-010119-t1x9gknd 8274 13 of of IN cord-010119-t1x9gknd 8274 14 all all DT cord-010119-t1x9gknd 8274 15 , , , cord-010119-t1x9gknd 8274 16 being be VBG cord-010119-t1x9gknd 8274 17 the the DT cord-010119-t1x9gknd 8274 18 error error NN cord-010119-t1x9gknd 8274 19 in in IN cord-010119-t1x9gknd 8274 20 concordance concordance NN cord-010119-t1x9gknd 8274 21 between between IN cord-010119-t1x9gknd 8274 22 the the DT cord-010119-t1x9gknd 8274 23 transfusion transfusion NN cord-010119-t1x9gknd 8274 24 security security NN cord-010119-t1x9gknd 8274 25 number number NN cord-010119-t1x9gknd 8274 26 in in IN cord-010119-t1x9gknd 8274 27 the the DT cord-010119-t1x9gknd 8274 28 bracelet bracelet NN cord-010119-t1x9gknd 8274 29 and and CC cord-010119-t1x9gknd 8274 30 in in IN cord-010119-t1x9gknd 8274 31 pretransfusion pretransfusion NNP cord-010119-t1x9gknd 8274 32 sample sample NN cord-010119-t1x9gknd 8274 33 the the DT cord-010119-t1x9gknd 8274 34 most most RBS cord-010119-t1x9gknd 8274 35 frequent frequent JJ cord-010119-t1x9gknd 8274 36 ( ( -LRB- cord-010119-t1x9gknd 8274 37 65.84 65.84 CD cord-010119-t1x9gknd 8274 38 % % NN cord-010119-t1x9gknd 8274 39 ) ) -RRB- cord-010119-t1x9gknd 8274 40 . . . cord-010119-t1x9gknd 8275 1 The the DT cord-010119-t1x9gknd 8275 2 NM NM NNP cord-010119-t1x9gknd 8275 3 detected detect VBD cord-010119-t1x9gknd 8275 4 in in IN cord-010119-t1x9gknd 8275 5 BCAS BCAS NNP cord-010119-t1x9gknd 8275 6 accounts account VBZ cord-010119-t1x9gknd 8275 7 for for IN cord-010119-t1x9gknd 8275 8 24.48 24.48 CD cord-010119-t1x9gknd 8275 9 % % NN cord-010119-t1x9gknd 8275 10 of of IN cord-010119-t1x9gknd 8275 11 all all DT cord-010119-t1x9gknd 8275 12 and and CC cord-010119-t1x9gknd 8275 13 in in IN cord-010119-t1x9gknd 8275 14 69.08 69.08 CD cord-010119-t1x9gknd 8275 15 % % NN cord-010119-t1x9gknd 8275 16 occurs occur VBZ cord-010119-t1x9gknd 8275 17 when when WRB cord-010119-t1x9gknd 8275 18 the the DT cord-010119-t1x9gknd 8275 19 patient patient JJ cord-010119-t1x9gknd 8275 20 information information NN cord-010119-t1x9gknd 8275 21 in in IN cord-010119-t1x9gknd 8275 22 the the DT cord-010119-t1x9gknd 8275 23 TIS TIS NNP cord-010119-t1x9gknd 8275 24 does do VBZ cord-010119-t1x9gknd 8275 25 not not RB cord-010119-t1x9gknd 8275 26 match match VB cord-010119-t1x9gknd 8275 27 with with IN cord-010119-t1x9gknd 8275 28 the the DT cord-010119-t1x9gknd 8275 29 one one CD cord-010119-t1x9gknd 8275 30 registered register VBN cord-010119-t1x9gknd 8275 31 in in IN cord-010119-t1x9gknd 8275 32 the the DT cord-010119-t1x9gknd 8275 33 TSS TSS NNP cord-010119-t1x9gknd 8275 34 . . . cord-010119-t1x9gknd 8276 1 The the DT cord-010119-t1x9gknd 8276 2 NM NM NNP cord-010119-t1x9gknd 8276 3 detected detect VBD cord-010119-t1x9gknd 8276 4 in in IN cord-010119-t1x9gknd 8276 5 BCA BCA NNP cord-010119-t1x9gknd 8276 6 are be VBP cord-010119-t1x9gknd 8276 7 28.02 28.02 CD cord-010119-t1x9gknd 8276 8 % % NN cord-010119-t1x9gknd 8276 9 of of IN cord-010119-t1x9gknd 8276 10 all all DT cord-010119-t1x9gknd 8276 11 and and CC cord-010119-t1x9gknd 8276 12 in in IN cord-010119-t1x9gknd 8276 13 65.61 65.61 CD cord-010119-t1x9gknd 8276 14 % % NN cord-010119-t1x9gknd 8276 15 of of IN cord-010119-t1x9gknd 8276 16 them -PRON- PRP cord-010119-t1x9gknd 8276 17 the the DT cord-010119-t1x9gknd 8276 18 blood blood NN cord-010119-t1x9gknd 8276 19 components component NNS cord-010119-t1x9gknd 8276 20 were be VBD cord-010119-t1x9gknd 8276 21 assigned assign VBN cord-010119-t1x9gknd 8276 22 to to IN cord-010119-t1x9gknd 8276 23 another another DT cord-010119-t1x9gknd 8276 24 patient patient NN cord-010119-t1x9gknd 8276 25 . . . cord-010119-t1x9gknd 8277 1 ( ( -LRB- cord-010119-t1x9gknd 8277 2 1 1 CD cord-010119-t1x9gknd 8277 3 , , , cord-010119-t1x9gknd 8277 4 3 3 CD cord-010119-t1x9gknd 8277 5 , , , cord-010119-t1x9gknd 8277 6 4 4 CD cord-010119-t1x9gknd 8277 7 , , , cord-010119-t1x9gknd 8277 8 5 5 CD cord-010119-t1x9gknd 8277 9 , , , cord-010119-t1x9gknd 8277 10 8 8 CD cord-010119-t1x9gknd 8277 11 , , , cord-010119-t1x9gknd 8277 12 9 9 CD cord-010119-t1x9gknd 8277 13 , , , cord-010119-t1x9gknd 8277 14 12 12 CD cord-010119-t1x9gknd 8277 15 , , , cord-010119-t1x9gknd 8277 16 14 14 CD cord-010119-t1x9gknd 8277 17 , , , cord-010119-t1x9gknd 8277 18 19 19 CD cord-010119-t1x9gknd 8277 19 , , , cord-010119-t1x9gknd 8277 20 23 23 CD cord-010119-t1x9gknd 8277 21 , , , cord-010119-t1x9gknd 8277 22 26 26 CD cord-010119-t1x9gknd 8277 23 , , , cord-010119-t1x9gknd 8277 24 51 51 CD cord-010119-t1x9gknd 8277 25 , , , cord-010119-t1x9gknd 8277 26 56 56 CD cord-010119-t1x9gknd 8277 27 , , , cord-010119-t1x9gknd 8277 28 68 68 CD cord-010119-t1x9gknd 8277 29 ) ) -RRB- cord-010119-t1x9gknd 8277 30 were be VBD cord-010119-t1x9gknd 8277 31 analyzed analyze VBN cord-010119-t1x9gknd 8277 32 via via IN cord-010119-t1x9gknd 8277 33 a a DT cord-010119-t1x9gknd 8277 34 commercially commercially RB cord-010119-t1x9gknd 8277 35 available available JJ cord-010119-t1x9gknd 8277 36 ELISA ELISA NNP cord-010119-t1x9gknd 8277 37 . . . cord-010119-t1x9gknd 8278 1 Comparison comparison NN cord-010119-t1x9gknd 8278 2 of of IN cord-010119-t1x9gknd 8278 3 adequate adequate JJ cord-010119-t1x9gknd 8278 4 response response NN cord-010119-t1x9gknd 8278 5 to to IN cord-010119-t1x9gknd 8278 6 PPV23 PPV23 NNP cord-010119-t1x9gknd 8278 7 , , , cord-010119-t1x9gknd 8278 8 defined define VBN cord-010119-t1x9gknd 8278 9 as as IN cord-010119-t1x9gknd 8278 10 ! ! . cord-010119-t1x9gknd 8279 1 2 2 CD cord-010119-t1x9gknd 8279 2 mcg mcg NN cord-010119-t1x9gknd 8279 3 / / SYM cord-010119-t1x9gknd 8279 4 mL ml NN cord-010119-t1x9gknd 8279 5 for for IN cord-010119-t1x9gknd 8279 6 > > XX cord-010119-t1x9gknd 8279 7 7 7 CD cord-010119-t1x9gknd 8279 8 serotypes serotype NNS cord-010119-t1x9gknd 8279 9 , , , cord-010119-t1x9gknd 8279 10 was be VBD cord-010119-t1x9gknd 8279 11 perform perform RB cord-010119-t1x9gknd 8279 12 based base VBN cord-010119-t1x9gknd 8279 13 on on IN cord-010119-t1x9gknd 8279 14 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8279 15 status status NN cord-010119-t1x9gknd 8279 16 . . . cord-010119-t1x9gknd 8280 1 Statistical statistical JJ cord-010119-t1x9gknd 8280 2 significance significance NN cord-010119-t1x9gknd 8280 3 was be VBD cord-010119-t1x9gknd 8280 4 determined determine VBN cord-010119-t1x9gknd 8280 5 by by IN cord-010119-t1x9gknd 8280 6 comparing compare VBG cord-010119-t1x9gknd 8280 7 means mean NNS cord-010119-t1x9gknd 8280 8 of of IN cord-010119-t1x9gknd 8280 9 subgroups subgroup NNS cord-010119-t1x9gknd 8280 10 using use VBG cord-010119-t1x9gknd 8280 11 paired pair VBN cord-010119-t1x9gknd 8280 12 and and CC cord-010119-t1x9gknd 8280 13 non non JJ cord-010119-t1x9gknd 8280 14 - - JJ cord-010119-t1x9gknd 8280 15 paired paired JJ cord-010119-t1x9gknd 8280 16 t t NN cord-010119-t1x9gknd 8280 17 - - HYPH cord-010119-t1x9gknd 8280 18 tests test NNS cord-010119-t1x9gknd 8280 19 . . . cord-010119-t1x9gknd 8281 1 Results result NNS cord-010119-t1x9gknd 8281 2 / / SYM cord-010119-t1x9gknd 8281 3 Findings finding NNS cord-010119-t1x9gknd 8281 4 : : : cord-010119-t1x9gknd 8282 1 Pre pre JJ cord-010119-t1x9gknd 8282 2 - - JJ cord-010119-t1x9gknd 8282 3 vaccine vaccine NN cord-010119-t1x9gknd 8282 4 SP SP NNP cord-010119-t1x9gknd 8282 5 titers titer NNS cord-010119-t1x9gknd 8282 6 were be VBD cord-010119-t1x9gknd 8282 7 available available JJ cord-010119-t1x9gknd 8282 8 in in IN cord-010119-t1x9gknd 8282 9 72 72 CD cord-010119-t1x9gknd 8282 10 patients patient NNS cord-010119-t1x9gknd 8282 11 ( ( -LRB- cord-010119-t1x9gknd 8282 12 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 8282 13 , , , cord-010119-t1x9gknd 8282 14 15 15 CD cord-010119-t1x9gknd 8282 15 ) ) -RRB- cord-010119-t1x9gknd 8282 16 ; ; : cord-010119-t1x9gknd 8282 17 pre pre VB cord-010119-t1x9gknd 8282 18 - - JJ cord-010119-t1x9gknd 8282 19 and and CC cord-010119-t1x9gknd 8282 20 post post JJ cord-010119-t1x9gknd 8282 21 - - JJ cord-010119-t1x9gknd 8282 22 vaccine vaccine NN cord-010119-t1x9gknd 8282 23 titers titer NNS cord-010119-t1x9gknd 8282 24 were be VBD cord-010119-t1x9gknd 8282 25 available available JJ cord-010119-t1x9gknd 8282 26 for for IN cord-010119-t1x9gknd 8282 27 19 19 CD cord-010119-t1x9gknd 8282 28 patients patient NNS cord-010119-t1x9gknd 8282 29 ( ( -LRB- cord-010119-t1x9gknd 8282 30 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 8282 31 , , , cord-010119-t1x9gknd 8282 32 6 6 CD cord-010119-t1x9gknd 8282 33 ) ) -RRB- cord-010119-t1x9gknd 8282 34 . . . cord-010119-t1x9gknd 8283 1 Of of IN cord-010119-t1x9gknd 8283 2 the the DT cord-010119-t1x9gknd 8283 3 72 72 CD cord-010119-t1x9gknd 8283 4 patients patient NNS cord-010119-t1x9gknd 8283 5 , , , cord-010119-t1x9gknd 8283 6 25 25 CD cord-010119-t1x9gknd 8283 7 were be VBD cord-010119-t1x9gknd 8283 8 on on IN cord-010119-t1x9gknd 8283 9 chronic chronic JJ cord-010119-t1x9gknd 8283 10 transfusions transfusion NNS cord-010119-t1x9gknd 8283 11 , , , cord-010119-t1x9gknd 8283 12 24 24 CD cord-010119-t1x9gknd 8283 13 were be VBD cord-010119-t1x9gknd 8283 14 on on IN cord-010119-t1x9gknd 8283 15 hydroxyurea hydroxyurea NNP cord-010119-t1x9gknd 8283 16 , , , cord-010119-t1x9gknd 8283 17 11 11 CD cord-010119-t1x9gknd 8283 18 were be VBD cord-010119-t1x9gknd 8283 19 surgical surgical JJ cord-010119-t1x9gknd 8283 20 splenectomized splenectomize VBN cord-010119-t1x9gknd 8283 21 , , , cord-010119-t1x9gknd 8283 22 58 58 CD cord-010119-t1x9gknd 8283 23 patients patient NNS cord-010119-t1x9gknd 8283 24 had have VBD cord-010119-t1x9gknd 8283 25 no no DT cord-010119-t1x9gknd 8283 26 history history NN cord-010119-t1x9gknd 8283 27 of of IN cord-010119-t1x9gknd 8283 28 surgical surgical JJ cord-010119-t1x9gknd 8283 29 splenectomy splenectomy NN cord-010119-t1x9gknd 8283 30 or or CC cord-010119-t1x9gknd 8283 31 status status NN cord-010119-t1x9gknd 8283 32 was be VBD cord-010119-t1x9gknd 8283 33 unknown unknown JJ cord-010119-t1x9gknd 8283 34 . . . cord-010119-t1x9gknd 8284 1 Forty forty CD cord-010119-t1x9gknd 8284 2 - - HYPH cord-010119-t1x9gknd 8284 3 four four CD cord-010119-t1x9gknd 8284 4 patients patient NNS cord-010119-t1x9gknd 8284 5 had have VBD cord-010119-t1x9gknd 8284 6 a a DT cord-010119-t1x9gknd 8284 7 previous previous JJ cord-010119-t1x9gknd 8284 8 history history NN cord-010119-t1x9gknd 8284 9 of of IN cord-010119-t1x9gknd 8284 10 PPV23 PPV23 NNP cord-010119-t1x9gknd 8284 11 in in IN cord-010119-t1x9gknd 8284 12 the the DT cord-010119-t1x9gknd 8284 13 previous previous JJ cord-010119-t1x9gknd 8284 14 10 10 CD cord-010119-t1x9gknd 8284 15 years year NNS cord-010119-t1x9gknd 8284 16 ; ; : cord-010119-t1x9gknd 8284 17 9/44 9/44 CD cord-010119-t1x9gknd 8284 18 also also RB cord-010119-t1x9gknd 8284 19 reported report VBD cord-010119-t1x9gknd 8284 20 previous previous JJ cord-010119-t1x9gknd 8284 21 history history NN cord-010119-t1x9gknd 8284 22 13-valent 13-valent CD cord-010119-t1x9gknd 8284 23 SP SP NNP cord-010119-t1x9gknd 8284 24 conjugate conjugate NN cord-010119-t1x9gknd 8284 25 vaccine vaccine NN cord-010119-t1x9gknd 8284 26 within within IN cord-010119-t1x9gknd 8284 27 the the DT cord-010119-t1x9gknd 8284 28 last last JJ cord-010119-t1x9gknd 8284 29 5 5 CD cord-010119-t1x9gknd 8284 30 years year NNS cord-010119-t1x9gknd 8284 31 . . . cord-010119-t1x9gknd 8285 1 Baseline baseline JJ cord-010119-t1x9gknd 8285 2 pre pre JJ cord-010119-t1x9gknd 8285 3 - - JJ cord-010119-t1x9gknd 8285 4 vaccination vaccination JJ cord-010119-t1x9gknd 8285 5 titers titer NNS cord-010119-t1x9gknd 8285 6 ( ( -LRB- cord-010119-t1x9gknd 8285 7 N572 N572 NNP cord-010119-t1x9gknd 8285 8 ) ) -RRB- cord-010119-t1x9gknd 8285 9 showed show VBD cord-010119-t1x9gknd 8285 10 no no DT cord-010119-t1x9gknd 8285 11 difference difference NN cord-010119-t1x9gknd 8285 12 between between IN cord-010119-t1x9gknd 8285 13 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 8285 14 and and CC cord-010119-t1x9gknd 8285 15 non non JJ cord-010119-t1x9gknd 8285 16 - - JJ cord-010119-t1x9gknd 8285 17 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 8285 18 patients patient NNS cord-010119-t1x9gknd 8285 19 ( ( -LRB- cord-010119-t1x9gknd 8285 20 all all DT cord-010119-t1x9gknd 8285 21 p p NN cord-010119-t1x9gknd 8285 22 - - HYPH cord-010119-t1x9gknd 8285 23 values value NNS cord-010119-t1x9gknd 8285 24 > > XX cord-010119-t1x9gknd 8285 25 0.13 0.13 CD cord-010119-t1x9gknd 8285 26 ) ) -RRB- cord-010119-t1x9gknd 8285 27 . . . cord-010119-t1x9gknd 8286 1 In in IN cord-010119-t1x9gknd 8286 2 the the DT cord-010119-t1x9gknd 8286 3 group group NN cord-010119-t1x9gknd 8286 4 with with IN cord-010119-t1x9gknd 8286 5 pre pre JJ cord-010119-t1x9gknd 8286 6 - - JJ cord-010119-t1x9gknd 8286 7 and and CC cord-010119-t1x9gknd 8286 8 post post JJ cord-010119-t1x9gknd 8286 9 - - JJ cord-010119-t1x9gknd 8286 10 vaccination vaccination NN cord-010119-t1x9gknd 8286 11 ( ( -LRB- cord-010119-t1x9gknd 8286 12 N519 N519 NNP cord-010119-t1x9gknd 8286 13 ) ) -RRB- cord-010119-t1x9gknd 8286 14 titers titer NNS cord-010119-t1x9gknd 8286 15 available available JJ cord-010119-t1x9gknd 8286 16 , , , cord-010119-t1x9gknd 8286 17 11 11 CD cord-010119-t1x9gknd 8286 18 out out IN cord-010119-t1x9gknd 8286 19 of of IN cord-010119-t1x9gknd 8286 20 13 13 CD cord-010119-t1x9gknd 8286 21 ( ( -LRB- cord-010119-t1x9gknd 8286 22 85 85 CD cord-010119-t1x9gknd 8286 23 % % NN cord-010119-t1x9gknd 8286 24 ) ) -RRB- cord-010119-t1x9gknd 8287 1 non non JJ cord-010119-t1x9gknd 8287 2 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 8287 3 patients patient NNS cord-010119-t1x9gknd 8287 4 had have VBD cord-010119-t1x9gknd 8287 5 an an DT cord-010119-t1x9gknd 8287 6 adequate adequate JJ cord-010119-t1x9gknd 8287 7 response response NN cord-010119-t1x9gknd 8287 8 versus versus IN cord-010119-t1x9gknd 8287 9 4 4 CD cord-010119-t1x9gknd 8287 10 out out IN cord-010119-t1x9gknd 8287 11 of of IN cord-010119-t1x9gknd 8287 12 6 6 CD cord-010119-t1x9gknd 8287 13 in in IN cord-010119-t1x9gknd 8287 14 the the DT cord-010119-t1x9gknd 8287 15 alloimmunized alloimmunized JJ cord-010119-t1x9gknd 8287 16 group group NN cord-010119-t1x9gknd 8287 17 ( ( -LRB- cord-010119-t1x9gknd 8287 18 67 67 CD cord-010119-t1x9gknd 8287 19 % % NN cord-010119-t1x9gknd 8287 20 , , , cord-010119-t1x9gknd 8287 21 p p NN cord-010119-t1x9gknd 8287 22 5NS 5ns CD cord-010119-t1x9gknd 8287 23 Background Background NNP cord-010119-t1x9gknd 8287 24 / / SYM cord-010119-t1x9gknd 8287 25 Case Case NNP cord-010119-t1x9gknd 8287 26 Studies Studies NNPS cord-010119-t1x9gknd 8287 27 : : : cord-010119-t1x9gknd 8288 1 Blood blood NN cord-010119-t1x9gknd 8288 2 transfusion transfusion NN cord-010119-t1x9gknd 8288 3 is be VBZ cord-010119-t1x9gknd 8288 4 the the DT cord-010119-t1x9gknd 8288 5 most most RBS cord-010119-t1x9gknd 8288 6 common common JJ cord-010119-t1x9gknd 8288 7 procedure procedure NN cord-010119-t1x9gknd 8288 8 performed perform VBN cord-010119-t1x9gknd 8288 9 in in IN cord-010119-t1x9gknd 8288 10 the the DT cord-010119-t1x9gknd 8288 11 hospital hospital NN cord-010119-t1x9gknd 8288 12 setting setting NN cord-010119-t1x9gknd 8288 13 and and CC cord-010119-t1x9gknd 8288 14 the the DT cord-010119-t1x9gknd 8288 15 transfusion transfusion NN cord-010119-t1x9gknd 8288 16 process process NN cord-010119-t1x9gknd 8288 17 is be VBZ cord-010119-t1x9gknd 8288 18 monitored monitor VBN cord-010119-t1x9gknd 8288 19 to to TO cord-010119-t1x9gknd 8288 20 ensure ensure VB cord-010119-t1x9gknd 8288 21 regulatory regulatory JJ cord-010119-t1x9gknd 8288 22 compliance compliance NN cord-010119-t1x9gknd 8288 23 . . . cord-010119-t1x9gknd 8289 1 To to TO cord-010119-t1x9gknd 8289 2 safeguard safeguard VB cord-010119-t1x9gknd 8289 3 safety safety NN cord-010119-t1x9gknd 8289 4 , , , cord-010119-t1x9gknd 8289 5 efficacy efficacy NN cord-010119-t1x9gknd 8289 6 and and CC cord-010119-t1x9gknd 8289 7 regulatory regulatory JJ cord-010119-t1x9gknd 8289 8 compliance compliance NN cord-010119-t1x9gknd 8289 9 , , , cord-010119-t1x9gknd 8289 10 transfusion transfusion NN cord-010119-t1x9gknd 8289 11 services service NNS cord-010119-t1x9gknd 8289 12 actively actively RB cord-010119-t1x9gknd 8289 13 benchmark benchmark JJ cord-010119-t1x9gknd 8289 14 transfusionrelated transfusionrelate VBN cord-010119-t1x9gknd 8289 15 errors error NNS cord-010119-t1x9gknd 8289 16 ( ( -LRB- cord-010119-t1x9gknd 8289 17 TREs TREs NNP cord-010119-t1x9gknd 8289 18 ) ) -RRB- cord-010119-t1x9gknd 8289 19 as as IN cord-010119-t1x9gknd 8289 20 they -PRON- PRP cord-010119-t1x9gknd 8289 21 occur occur VBP cord-010119-t1x9gknd 8289 22 from from IN cord-010119-t1x9gknd 8289 23 " " `` cord-010119-t1x9gknd 8289 24 vein vein NN cord-010119-t1x9gknd 8289 25 - - HYPH cord-010119-t1x9gknd 8289 26 to to IN cord-010119-t1x9gknd 8289 27 - - HYPH cord-010119-t1x9gknd 8289 28 vein vein NN cord-010119-t1x9gknd 8289 29 " " '' cord-010119-t1x9gknd 8289 30 , , , cord-010119-t1x9gknd 8289 31 i.e. i.e. FW cord-010119-t1x9gknd 8289 32 from from IN cord-010119-t1x9gknd 8289 33 collection collection NN cord-010119-t1x9gknd 8289 34 of of IN cord-010119-t1x9gknd 8289 35 pre pre JJ cord-010119-t1x9gknd 8289 36 - - JJ cord-010119-t1x9gknd 8289 37 transfusion transfusion JJ cord-010119-t1x9gknd 8289 38 sample sample NN cord-010119-t1x9gknd 8289 39 to to IN cord-010119-t1x9gknd 8289 40 final final JJ cord-010119-t1x9gknd 8289 41 infusion infusion NN cord-010119-t1x9gknd 8289 42 of of IN cord-010119-t1x9gknd 8289 43 product product NN cord-010119-t1x9gknd 8289 44 -with -with . cord-010119-t1x9gknd 8290 1 the the DT cord-010119-t1x9gknd 8290 2 goal goal NN cord-010119-t1x9gknd 8290 3 of of IN cord-010119-t1x9gknd 8290 4 ensuring ensure VBG cord-010119-t1x9gknd 8290 5 that that IN cord-010119-t1x9gknd 8290 6 the the DT cord-010119-t1x9gknd 8290 7 right right JJ cord-010119-t1x9gknd 8290 8 product product NN cord-010119-t1x9gknd 8290 9 / / SYM cord-010119-t1x9gknd 8290 10 dose dose NN cord-010119-t1x9gknd 8290 11 goes go VBZ cord-010119-t1x9gknd 8290 12 to to IN cord-010119-t1x9gknd 8290 13 the the DT cord-010119-t1x9gknd 8290 14 right right JJ cord-010119-t1x9gknd 8290 15 patient patient NN cord-010119-t1x9gknd 8290 16 at at IN cord-010119-t1x9gknd 8290 17 the the DT cord-010119-t1x9gknd 8290 18 right right JJ cord-010119-t1x9gknd 8290 19 time time NN cord-010119-t1x9gknd 8290 20 . . . cord-010119-t1x9gknd 8291 1 Multiple multiple JJ cord-010119-t1x9gknd 8291 2 over over RB cord-010119-t1x9gknd 8291 3 - - HYPH cord-010119-t1x9gknd 8291 4 lapping lap VBG cord-010119-t1x9gknd 8291 5 error error NN cord-010119-t1x9gknd 8291 6 documentation documentation NN cord-010119-t1x9gknd 8291 7 processes process NNS cord-010119-t1x9gknd 8291 8 are be VBP cord-010119-t1x9gknd 8291 9 needed need VBN cord-010119-t1x9gknd 8291 10 to to TO cord-010119-t1x9gknd 8291 11 capture capture VB cord-010119-t1x9gknd 8291 12 and and CC cord-010119-t1x9gknd 8291 13 report report VB cord-010119-t1x9gknd 8291 14 TREs tre NNS cord-010119-t1x9gknd 8291 15 from from IN cord-010119-t1x9gknd 8291 16 within within IN cord-010119-t1x9gknd 8291 17 and and CC cord-010119-t1x9gknd 8291 18 outside outside RB cord-010119-t1x9gknd 8291 19 of of IN cord-010119-t1x9gknd 8291 20 Blood Blood NNP cord-010119-t1x9gknd 8291 21 Bank Bank NNP cord-010119-t1x9gknd 8291 22 ( ( -LRB- cord-010119-t1x9gknd 8291 23 BB BB NNP cord-010119-t1x9gknd 8291 24 ) ) -RRB- cord-010119-t1x9gknd 8291 25 . . . cord-010119-t1x9gknd 8292 1 We -PRON- PRP cord-010119-t1x9gknd 8292 2 present present VBP cord-010119-t1x9gknd 8292 3 a a DT cord-010119-t1x9gknd 8292 4 comprehensive comprehensive JJ cord-010119-t1x9gknd 8292 5 error error NN cord-010119-t1x9gknd 8292 6 management management NN cord-010119-t1x9gknd 8292 7 program program NN cord-010119-t1x9gknd 8292 8 along along IN cord-010119-t1x9gknd 8292 9 with with IN cord-010119-t1x9gknd 8292 10 data datum NNS cord-010119-t1x9gknd 8292 11 on on IN cord-010119-t1x9gknd 8292 12 five five CD cord-010119-t1x9gknd 8292 13 years year NNS cord-010119-t1x9gknd 8292 14 of of IN cord-010119-t1x9gknd 8292 15 benchmarking benchmarking NN cord-010119-t1x9gknd 8292 16 TREs tre NNS cord-010119-t1x9gknd 8292 17 at at IN cord-010119-t1x9gknd 8292 18 a a DT cord-010119-t1x9gknd 8292 19 large large JJ cord-010119-t1x9gknd 8292 20 academic academic JJ cord-010119-t1x9gknd 8292 21 medical medical JJ cord-010119-t1x9gknd 8292 22 center center NN cord-010119-t1x9gknd 8292 23 . . . cord-010119-t1x9gknd 8293 1 Study Study NNP cord-010119-t1x9gknd 8293 2 Design Design NNP cord-010119-t1x9gknd 8293 3 / / SYM cord-010119-t1x9gknd 8293 4 Method method NN cord-010119-t1x9gknd 8293 5 : : : cord-010119-t1x9gknd 8294 1 TREs TREs NNP cord-010119-t1x9gknd 8294 2 were be VBD cord-010119-t1x9gknd 8294 3 detected detect VBN cord-010119-t1x9gknd 8294 4 by by IN cord-010119-t1x9gknd 8294 5 capturing capture VBG cord-010119-t1x9gknd 8294 6 and and CC cord-010119-t1x9gknd 8294 7 reporting reporting NN cord-010119-t1x9gknd 8294 8 of of IN cord-010119-t1x9gknd 8294 9 sample sample NN cord-010119-t1x9gknd 8294 10 suitability suitability NN cord-010119-t1x9gknd 8294 11 , , , cord-010119-t1x9gknd 8294 12 testing test VBG cord-010119-t1x9gknd 8294 13 variances variance NNS cord-010119-t1x9gknd 8294 14 and and CC cord-010119-t1x9gknd 8294 15 biologic biologic JJ cord-010119-t1x9gknd 8294 16 product product NN cord-010119-t1x9gknd 8294 17 deviations deviation NNS cord-010119-t1x9gknd 8294 18 . . . cord-010119-t1x9gknd 8295 1 In in IN cord-010119-t1x9gknd 8295 2 addition addition NN cord-010119-t1x9gknd 8295 3 , , , cord-010119-t1x9gknd 8295 4 TREs TREs NNP cord-010119-t1x9gknd 8295 5 as as IN cord-010119-t1x9gknd 8295 6 observed observe VBN cord-010119-t1x9gknd 8295 7 and and CC cord-010119-t1x9gknd 8295 8 reported report VBN cord-010119-t1x9gknd 8295 9 by by IN cord-010119-t1x9gknd 8295 10 providers provider NNS cord-010119-t1x9gknd 8295 11 and and CC cord-010119-t1x9gknd 8295 12 clinical clinical JJ cord-010119-t1x9gknd 8295 13 staff staff NN cord-010119-t1x9gknd 8295 14 ( ( -LRB- cord-010119-t1x9gknd 8295 15 i.e. i.e. FW cord-010119-t1x9gknd 8295 16 blood blood NN cord-010119-t1x9gknd 8295 17 delays delay NNS cord-010119-t1x9gknd 8295 18 / / SYM cord-010119-t1x9gknd 8295 19 undertransfusions undertransfusion NNS cord-010119-t1x9gknd 8295 20 , , , cord-010119-t1x9gknd 8295 21 transfusions transfusion NNS cord-010119-t1x9gknd 8295 22 without without IN cord-010119-t1x9gknd 8295 23 consent consent NN cord-010119-t1x9gknd 8295 24 , , , cord-010119-t1x9gknd 8295 25 infusions infusion NNS cord-010119-t1x9gknd 8295 26 with with IN cord-010119-t1x9gknd 8295 27 wrong wrong JJ cord-010119-t1x9gknd 8295 28 fluids fluid NNS cord-010119-t1x9gknd 8295 29 ) ) -RRB- cord-010119-t1x9gknd 8295 30 were be VBD cord-010119-t1x9gknd 8295 31 reported report VBN cord-010119-t1x9gknd 8295 32 to to IN cord-010119-t1x9gknd 8295 33 the the DT cord-010119-t1x9gknd 8295 34 BB bb NN cord-010119-t1x9gknd 8295 35 and and CC cord-010119-t1x9gknd 8295 36 hospital hospital NN cord-010119-t1x9gknd 8295 37 quality quality NN cord-010119-t1x9gknd 8295 38 through through IN cord-010119-t1x9gknd 8295 39 the the DT cord-010119-t1x9gknd 8295 40 Veritas Veritas NNP cord-010119-t1x9gknd 8295 41 system system NN cord-010119-t1x9gknd 8295 42 , , , cord-010119-t1x9gknd 8295 43 a a DT cord-010119-t1x9gknd 8295 44 hospital hospital NN cord-010119-t1x9gknd 8295 45 based base VBN cord-010119-t1x9gknd 8295 46 reporting reporting NN cord-010119-t1x9gknd 8295 47 system system NN cord-010119-t1x9gknd 8295 48 that that WDT cord-010119-t1x9gknd 8295 49 enables enable VBZ cord-010119-t1x9gknd 8295 50 reporting report VBG cord-010119-t1x9gknd 8295 51 any any DT cord-010119-t1x9gknd 8295 52 occurrence occurrence NN cord-010119-t1x9gknd 8295 53 with with IN cord-010119-t1x9gknd 8295 54 potential potential NN cord-010119-t1x9gknd 8295 55 for for IN cord-010119-t1x9gknd 8295 56 causing cause VBG cord-010119-t1x9gknd 8295 57 patient patient JJ cord-010119-t1x9gknd 8295 58 harm harm NN cord-010119-t1x9gknd 8295 59 . . . cord-010119-t1x9gknd 8296 1 All all DT cord-010119-t1x9gknd 8296 2 serious serious JJ cord-010119-t1x9gknd 8296 3 errors error NNS cord-010119-t1x9gknd 8296 4 were be VBD cord-010119-t1x9gknd 8296 5 reviewed review VBN cord-010119-t1x9gknd 8296 6 daily daily JJ cord-010119-t1x9gknd 8296 7 and and CC cord-010119-t1x9gknd 8296 8 summation summation NN cord-010119-t1x9gknd 8296 9 of of IN cord-010119-t1x9gknd 8296 10 TREs TREs NNP cord-010119-t1x9gknd 8296 11 was be VBD cord-010119-t1x9gknd 8296 12 discussed discuss VBN cord-010119-t1x9gknd 8296 13 on on IN cord-010119-t1x9gknd 8296 14 a a DT cord-010119-t1x9gknd 8296 15 monthly monthly JJ cord-010119-t1x9gknd 8296 16 basis basis NN cord-010119-t1x9gknd 8296 17 . . . cord-010119-t1x9gknd 8297 1 Mapping mapping NN cord-010119-t1x9gknd 8297 2 TREs tre NNS cord-010119-t1x9gknd 8297 3 within within IN cord-010119-t1x9gknd 8297 4 the the DT cord-010119-t1x9gknd 8297 5 " " `` cord-010119-t1x9gknd 8297 6 vein vein NN cord-010119-t1x9gknd 8297 7 - - HYPH cord-010119-t1x9gknd 8297 8 to to IN cord-010119-t1x9gknd 8297 9 - - HYPH cord-010119-t1x9gknd 8297 10 vein vein NN cord-010119-t1x9gknd 8297 11 " " '' cord-010119-t1x9gknd 8297 12 was be VBD cord-010119-t1x9gknd 8297 13 performed perform VBN cord-010119-t1x9gknd 8297 14 by by IN cord-010119-t1x9gknd 8297 15 reviewing review VBG cord-010119-t1x9gknd 8297 16 the the DT cord-010119-t1x9gknd 8297 17 fiveyear fiveyear NN cord-010119-t1x9gknd 8297 18 of of IN cord-010119-t1x9gknd 8297 19 transfusion transfusion NN cord-010119-t1x9gknd 8297 20 medicine medicine NN cord-010119-t1x9gknd 8297 21 quality quality NN cord-010119-t1x9gknd 8297 22 records record NNS cord-010119-t1x9gknd 8297 23 ( ( -LRB- cord-010119-t1x9gknd 8297 24 from from IN cord-010119-t1x9gknd 8297 25 2012 2012 CD cord-010119-t1x9gknd 8297 26 to to IN cord-010119-t1x9gknd 8297 27 2016 2016 CD cord-010119-t1x9gknd 8297 28 ) ) -RRB- cord-010119-t1x9gknd 8297 29 . . . cord-010119-t1x9gknd 8298 1 Patient patient JJ cord-010119-t1x9gknd 8298 2 harm harm NN cord-010119-t1x9gknd 8298 3 events event NNS cord-010119-t1x9gknd 8298 4 recorded record VBN cord-010119-t1x9gknd 8298 5 within within IN cord-010119-t1x9gknd 8298 6 the the DT cord-010119-t1x9gknd 8298 7 Veritas Veritas NNP cord-010119-t1x9gknd 8298 8 system system NN cord-010119-t1x9gknd 8298 9 from from IN cord-010119-t1x9gknd 8298 10 January January NNP cord-010119-t1x9gknd 8298 11 to to IN cord-010119-t1x9gknd 8298 12 July July NNP cord-010119-t1x9gknd 8298 13 2016 2016 CD cord-010119-t1x9gknd 8298 14 were be VBD cord-010119-t1x9gknd 8298 15 investigated investigate VBN cord-010119-t1x9gknd 8298 16 in in IN cord-010119-t1x9gknd 8298 17 depth depth NN cord-010119-t1x9gknd 8298 18 . . . cord-010119-t1x9gknd 8299 1 Transfusion transfusion NN cord-010119-t1x9gknd 8299 2 reactions reaction NNS cord-010119-t1x9gknd 8299 3 were be VBD cord-010119-t1x9gknd 8299 4 excluded exclude VBN cord-010119-t1x9gknd 8299 5 in in IN cord-010119-t1x9gknd 8299 6 this this DT cord-010119-t1x9gknd 8299 7 analysis analysis NN cord-010119-t1x9gknd 8299 8 . . . cord-010119-t1x9gknd 8300 1 Results result NNS cord-010119-t1x9gknd 8300 2 / / SYM cord-010119-t1x9gknd 8300 3 Finding finding NN cord-010119-t1x9gknd 8300 4 : : : cord-010119-t1x9gknd 8301 1 An an DT cord-010119-t1x9gknd 8301 2 average average NN cord-010119-t1x9gknd 8301 3 of of IN cord-010119-t1x9gknd 8301 4 114 114 CD cord-010119-t1x9gknd 8301 5 TREs tre NNS cord-010119-t1x9gknd 8301 6 per per IN cord-010119-t1x9gknd 8301 7 month month NN cord-010119-t1x9gknd 8301 8 and and CC cord-010119-t1x9gknd 8301 9 1300 1300 CD cord-010119-t1x9gknd 8301 10 per per IN cord-010119-t1x9gknd 8301 11 year year NN cord-010119-t1x9gknd 8301 12 were be VBD cord-010119-t1x9gknd 8301 13 found find VBN cord-010119-t1x9gknd 8301 14 over over IN cord-010119-t1x9gknd 8301 15 five five CD cord-010119-t1x9gknd 8301 16 years year NNS cord-010119-t1x9gknd 8301 17 . . . cord-010119-t1x9gknd 8302 1 81 81 CD cord-010119-t1x9gknd 8302 2 % % NN cord-010119-t1x9gknd 8302 3 of of IN cord-010119-t1x9gknd 8302 4 TREs tre NNS cord-010119-t1x9gknd 8302 5 are be VBP cord-010119-t1x9gknd 8302 6 associated associate VBN cord-010119-t1x9gknd 8302 7 with with IN cord-010119-t1x9gknd 8302 8 pre pre JJ cord-010119-t1x9gknd 8302 9 - - JJ cord-010119-t1x9gknd 8302 10 BB bb JJ cord-010119-t1x9gknd 8302 11 activities activity NNS cord-010119-t1x9gknd 8302 12 , , , cord-010119-t1x9gknd 8302 13 10 10 CD cord-010119-t1x9gknd 8302 14 % % NN cord-010119-t1x9gknd 8302 15 occur occur VBP cord-010119-t1x9gknd 8302 16 within within IN cord-010119-t1x9gknd 8302 17 BB bb NN cord-010119-t1x9gknd 8302 18 , , , cord-010119-t1x9gknd 8302 19 and and CC cord-010119-t1x9gknd 8302 20 9 9 CD cord-010119-t1x9gknd 8302 21 % % NN cord-010119-t1x9gknd 8302 22 are be VBP cord-010119-t1x9gknd 8302 23 post post JJ cord-010119-t1x9gknd 8302 24 - - JJ cord-010119-t1x9gknd 8302 25 BB bb JJ cord-010119-t1x9gknd 8302 26 events event NNS cord-010119-t1x9gknd 8302 27 . . . cord-010119-t1x9gknd 8303 1 Sample sample NN cord-010119-t1x9gknd 8303 2 collection collection NN cord-010119-t1x9gknd 8303 3 and and CC cord-010119-t1x9gknd 8303 4 handling handle VBG cord-010119-t1x9gknd 8303 5 represent represent VB cord-010119-t1x9gknd 8303 6 80 80 CD cord-010119-t1x9gknd 8303 7 % % NN cord-010119-t1x9gknd 8303 8 of of IN cord-010119-t1x9gknd 8303 9 total total JJ cord-010119-t1x9gknd 8303 10 TREs tre NNS cord-010119-t1x9gknd 8303 11 . . . cord-010119-t1x9gknd 8304 1 Most Most JJS cord-010119-t1x9gknd 8304 2 TREs tre NNS cord-010119-t1x9gknd 8304 3 ( ( -LRB- cord-010119-t1x9gknd 8304 4 96 96 CD cord-010119-t1x9gknd 8304 5 % % NN cord-010119-t1x9gknd 8304 6 ) ) -RRB- cord-010119-t1x9gknd 8304 7 were be VBD cord-010119-t1x9gknd 8304 8 reported report VBN cord-010119-t1x9gknd 8304 9 by by IN cord-010119-t1x9gknd 8304 10 BB BB NNP cord-010119-t1x9gknd 8304 11 staff staff NN cord-010119-t1x9gknd 8304 12 , , , cord-010119-t1x9gknd 8304 13 4 4 CD cord-010119-t1x9gknd 8304 14 % % NN cord-010119-t1x9gknd 8304 15 were be VBD cord-010119-t1x9gknd 8304 16 reported report VBN cord-010119-t1x9gknd 8304 17 by by IN cord-010119-t1x9gknd 8304 18 non non JJ cord-010119-t1x9gknd 8304 19 - - JJ cord-010119-t1x9gknd 8304 20 BB bb JJ cord-010119-t1x9gknd 8304 21 staff staff NN cord-010119-t1x9gknd 8304 22 . . . cord-010119-t1x9gknd 8305 1 Patient patient JJ cord-010119-t1x9gknd 8305 2 harm harm NN cord-010119-t1x9gknd 8305 3 analysis analysis NN cord-010119-t1x9gknd 8305 4 revealed reveal VBD cord-010119-t1x9gknd 8305 5 an an DT cord-010119-t1x9gknd 8305 6 average average NN cord-010119-t1x9gknd 8305 7 of of IN cord-010119-t1x9gknd 8305 8 four four CD cord-010119-t1x9gknd 8305 9 Level level NN cord-010119-t1x9gknd 8305 10 0 0 NFP cord-010119-t1x9gknd 8305 11 ( ( -LRB- cord-010119-t1x9gknd 8305 12 near near NNP cord-010119-t1x9gknd 8305 13 miss miss NNP cord-010119-t1x9gknd 8305 14 ) ) -RRB- cord-010119-t1x9gknd 8305 15 , , , cord-010119-t1x9gknd 8305 16 three three CD cord-010119-t1x9gknd 8305 17 Level level NN cord-010119-t1x9gknd 8305 18 1 1 CD cord-010119-t1x9gknd 8305 19 ( ( -LRB- cord-010119-t1x9gknd 8305 20 no no DT cord-010119-t1x9gknd 8305 21 known know VBN cord-010119-t1x9gknd 8305 22 harm harm NN cord-010119-t1x9gknd 8305 23 ) ) -RRB- cord-010119-t1x9gknd 8305 24 , , , cord-010119-t1x9gknd 8305 25 and and CC cord-010119-t1x9gknd 8305 26 0.3 0.3 CD cord-010119-t1x9gknd 8305 27 Level level NN cord-010119-t1x9gknd 8305 28 2 2 CD cord-010119-t1x9gknd 8305 29 ( ( -LRB- cord-010119-t1x9gknd 8305 30 patient patient JJ cord-010119-t1x9gknd 8305 31 harm harm NN cord-010119-t1x9gknd 8305 32 ) ) -RRB- cord-010119-t1x9gknd 8305 33 per per IN cord-010119-t1x9gknd 8305 34 month month NN cord-010119-t1x9gknd 8305 35 . . . cord-010119-t1x9gknd 8306 1 No no DT cord-010119-t1x9gknd 8306 2 deaths death NNS cord-010119-t1x9gknd 8306 3 related relate VBN cord-010119-t1x9gknd 8306 4 to to IN cord-010119-t1x9gknd 8306 5 TRE TRE NNP cord-010119-t1x9gknd 8306 6 were be VBD cord-010119-t1x9gknd 8306 7 detected detect VBN cord-010119-t1x9gknd 8306 8 over over IN cord-010119-t1x9gknd 8306 9 the the DT cord-010119-t1x9gknd 8306 10 seven seven CD cord-010119-t1x9gknd 8306 11 month month NN cord-010119-t1x9gknd 8306 12 January January NNP cord-010119-t1x9gknd 8306 13 to to IN cord-010119-t1x9gknd 8306 14 July July NNP cord-010119-t1x9gknd 8306 15 2016 2016 CD cord-010119-t1x9gknd 8306 16 period period NN cord-010119-t1x9gknd 8306 17 . . . cord-010119-t1x9gknd 8307 1 Patient patient JJ cord-010119-t1x9gknd 8307 2 harm harm NN cord-010119-t1x9gknd 8307 3 was be VBD cord-010119-t1x9gknd 8307 4 associated associate VBN cord-010119-t1x9gknd 8307 5 with with IN cord-010119-t1x9gknd 8307 6 TREs tre NNS cord-010119-t1x9gknd 8307 7 occurring occur VBG cord-010119-t1x9gknd 8307 8 in in IN cord-010119-t1x9gknd 8307 9 the the DT cord-010119-t1x9gknd 8307 10 BB bb NN cord-010119-t1x9gknd 8307 11 ( ( -LRB- cord-010119-t1x9gknd 8307 12 17 17 CD cord-010119-t1x9gknd 8307 13 % % NN cord-010119-t1x9gknd 8307 14 ) ) -RRB- cord-010119-t1x9gknd 8307 15 and and CC cord-010119-t1x9gknd 8307 16 post post JJ cord-010119-t1x9gknd 8307 17 - - JJ cord-010119-t1x9gknd 8307 18 BB bb JJ cord-010119-t1x9gknd 8307 19 ( ( -LRB- cord-010119-t1x9gknd 8307 20 83 83 CD cord-010119-t1x9gknd 8307 21 % % NN cord-010119-t1x9gknd 8307 22 ) ) -RRB- cord-010119-t1x9gknd 8307 23 . . . cord-010119-t1x9gknd 8308 1 These these DT cord-010119-t1x9gknd 8308 2 events event NNS cord-010119-t1x9gknd 8308 3 were be VBD cord-010119-t1x9gknd 8308 4 reported report VBN cord-010119-t1x9gknd 8308 5 externally externally RB cord-010119-t1x9gknd 8308 6 ( ( -LRB- cord-010119-t1x9gknd 8308 7 78 78 CD cord-010119-t1x9gknd 8308 8 % % NN cord-010119-t1x9gknd 8308 9 ) ) -RRB- cord-010119-t1x9gknd 8308 10 and and CC cord-010119-t1x9gknd 8308 11 by by IN cord-010119-t1x9gknd 8308 12 BB BB NNP cord-010119-t1x9gknd 8308 13 staff staff NN cord-010119-t1x9gknd 8308 14 ( ( -LRB- cord-010119-t1x9gknd 8308 15 22 22 CD cord-010119-t1x9gknd 8308 16 % % NN cord-010119-t1x9gknd 8308 17 ) ) -RRB- cord-010119-t1x9gknd 8308 18 . . . cord-010119-t1x9gknd 8309 1 Conclusion conclusion NN cord-010119-t1x9gknd 8309 2 : : : cord-010119-t1x9gknd 8310 1 Although although IN cord-010119-t1x9gknd 8310 2 most most JJS cord-010119-t1x9gknd 8310 3 TREs tre NNS cord-010119-t1x9gknd 8310 4 were be VBD cord-010119-t1x9gknd 8310 5 detected detect VBN cord-010119-t1x9gknd 8310 6 in in IN cord-010119-t1x9gknd 8310 7 the the DT cord-010119-t1x9gknd 8310 8 pre pre JJ cord-010119-t1x9gknd 8310 9 - - JJ cord-010119-t1x9gknd 8310 10 BB bb JJ cord-010119-t1x9gknd 8310 11 phase phase NN cord-010119-t1x9gknd 8310 12 , , , cord-010119-t1x9gknd 8310 13 no no DT cord-010119-t1x9gknd 8310 14 patient patient JJ cord-010119-t1x9gknd 8310 15 harm harm NN cord-010119-t1x9gknd 8310 16 was be VBD cord-010119-t1x9gknd 8310 17 associated associate VBN cord-010119-t1x9gknd 8310 18 with with IN cord-010119-t1x9gknd 8310 19 these these DT cord-010119-t1x9gknd 8310 20 events event NNS cord-010119-t1x9gknd 8310 21 indicating indicate VBG cord-010119-t1x9gknd 8310 22 an an DT cord-010119-t1x9gknd 8310 23 efficient efficient JJ cord-010119-t1x9gknd 8310 24 capture capture NN cord-010119-t1x9gknd 8310 25 prior prior RB cord-010119-t1x9gknd 8310 26 to to IN cord-010119-t1x9gknd 8310 27 causing cause VBG cord-010119-t1x9gknd 8310 28 patient patient JJ cord-010119-t1x9gknd 8310 29 harm harm NN cord-010119-t1x9gknd 8310 30 . . . cord-010119-t1x9gknd 8311 1 The the DT cord-010119-t1x9gknd 8311 2 TREs tre NNS cord-010119-t1x9gknd 8311 3 causing cause VBG cord-010119-t1x9gknd 8311 4 patient patient JJ cord-010119-t1x9gknd 8311 5 harm harm NN cord-010119-t1x9gknd 8311 6 , , , cord-010119-t1x9gknd 8311 7 including include VBG cord-010119-t1x9gknd 8311 8 near near IN cord-010119-t1x9gknd 8311 9 miss miss JJ cord-010119-t1x9gknd 8311 10 events event NNS cord-010119-t1x9gknd 8311 11 , , , cord-010119-t1x9gknd 8311 12 were be VBD cord-010119-t1x9gknd 8311 13 mostly mostly RB cord-010119-t1x9gknd 8311 14 reported report VBN cord-010119-t1x9gknd 8311 15 externally externally RB cord-010119-t1x9gknd 8311 16 and and CC cord-010119-t1x9gknd 8311 17 they -PRON- PRP cord-010119-t1x9gknd 8311 18 occurred occur VBD cord-010119-t1x9gknd 8311 19 entirely entirely RB cord-010119-t1x9gknd 8311 20 in in IN cord-010119-t1x9gknd 8311 21 the the DT cord-010119-t1x9gknd 8311 22 post post JJ cord-010119-t1x9gknd 8311 23 - - JJ cord-010119-t1x9gknd 8311 24 BB bb JJ cord-010119-t1x9gknd 8311 25 and and CC cord-010119-t1x9gknd 8311 26 BB BB NNP cord-010119-t1x9gknd 8311 27 phases phase NNS cord-010119-t1x9gknd 8311 28 . . . cord-010119-t1x9gknd 8312 1 These these DT cord-010119-t1x9gknd 8312 2 results result NNS cord-010119-t1x9gknd 8312 3 suggest suggest VBP cord-010119-t1x9gknd 8312 4 that that IN cord-010119-t1x9gknd 8312 5 significant significant JJ cord-010119-t1x9gknd 8312 6 opportunities opportunity NNS cord-010119-t1x9gknd 8312 7 for for IN cord-010119-t1x9gknd 8312 8 quality quality NN cord-010119-t1x9gknd 8312 9 improvement improvement NN cord-010119-t1x9gknd 8312 10 may may MD cord-010119-t1x9gknd 8312 11 be be VB cord-010119-t1x9gknd 8312 12 achieved achieve VBN cord-010119-t1x9gknd 8312 13 in in IN cord-010119-t1x9gknd 8312 14 two two CD cord-010119-t1x9gknd 8312 15 areas area NNS cord-010119-t1x9gknd 8312 16 : : : cord-010119-t1x9gknd 8312 17 the the DT cord-010119-t1x9gknd 8312 18 pre pre JJ cord-010119-t1x9gknd 8312 19 - - JJ cord-010119-t1x9gknd 8312 20 BB bb JJ cord-010119-t1x9gknd 8312 21 phase phase NN cord-010119-t1x9gknd 8312 22 aimed aim VBN cord-010119-t1x9gknd 8312 23 at at IN cord-010119-t1x9gknd 8312 24 reduction reduction NN cord-010119-t1x9gknd 8312 25 of of IN cord-010119-t1x9gknd 8312 26 waste waste NN cord-010119-t1x9gknd 8312 27 associated associate VBN cord-010119-t1x9gknd 8312 28 with with IN cord-010119-t1x9gknd 8312 29 sample sample NN cord-010119-t1x9gknd 8312 30 collection collection NN cord-010119-t1x9gknd 8312 31 and and CC cord-010119-t1x9gknd 8312 32 handling handling NN cord-010119-t1x9gknd 8312 33 , , , cord-010119-t1x9gknd 8312 34 and and CC cord-010119-t1x9gknd 8312 35 the the DT cord-010119-t1x9gknd 8312 36 post post JJ cord-010119-t1x9gknd 8312 37 - - JJ cord-010119-t1x9gknd 8312 38 BB bb JJ cord-010119-t1x9gknd 8312 39 and and CC cord-010119-t1x9gknd 8312 40 BB BB NNP cord-010119-t1x9gknd 8312 41 phases phase NNS cord-010119-t1x9gknd 8312 42 aimed aim VBN cord-010119-t1x9gknd 8312 43 at at IN cord-010119-t1x9gknd 8312 44 improving improve VBG cord-010119-t1x9gknd 8312 45 TRE TRE NNP cord-010119-t1x9gknd 8312 46 detection detection NN cord-010119-t1x9gknd 8312 47 and and CC cord-010119-t1x9gknd 8312 48 decreasing decrease VBG cord-010119-t1x9gknd 8312 49 patient patient JJ cord-010119-t1x9gknd 8312 50 harm harm NN cord-010119-t1x9gknd 8312 51 . . . cord-010119-t1x9gknd 8313 1 Background Background NNP cord-010119-t1x9gknd 8313 2 / / SYM cord-010119-t1x9gknd 8313 3 Case Case NNP cord-010119-t1x9gknd 8313 4 Studies Studies NNPS cord-010119-t1x9gknd 8313 5 : : : cord-010119-t1x9gknd 8313 6 Uncrossmatched uncrossmatched JJ cord-010119-t1x9gknd 8313 7 red red JJ cord-010119-t1x9gknd 8313 8 blood blood NN cord-010119-t1x9gknd 8313 9 cells cell NNS cord-010119-t1x9gknd 8313 10 ( ( -LRB- cord-010119-t1x9gknd 8313 11 RBC RBC NNP cord-010119-t1x9gknd 8313 12 ) ) -RRB- cord-010119-t1x9gknd 8313 13 and and CC cord-010119-t1x9gknd 8313 14 emergency emergency NN cord-010119-t1x9gknd 8313 15 issued issue VBD cord-010119-t1x9gknd 8313 16 platelets platelet NNS cord-010119-t1x9gknd 8313 17 ( ( -LRB- cord-010119-t1x9gknd 8313 18 PLT PLT NNP cord-010119-t1x9gknd 8313 19 ) ) -RRB- cord-010119-t1x9gknd 8313 20 , , , cord-010119-t1x9gknd 8313 21 plasma plasma NN cord-010119-t1x9gknd 8313 22 and and CC cord-010119-t1x9gknd 8313 23 cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 8313 24 ( ( -LRB- cord-010119-t1x9gknd 8313 25 CRYO CRYO NNP cord-010119-t1x9gknd 8313 26 ) ) -RRB- cord-010119-t1x9gknd 8314 1 are be VBP cord-010119-t1x9gknd 8314 2 lifesaving lifesave VBG cord-010119-t1x9gknd 8314 3 in in IN cord-010119-t1x9gknd 8314 4 a a DT cord-010119-t1x9gknd 8314 5 bleeding bleed VBG cord-010119-t1x9gknd 8314 6 patient patient NN cord-010119-t1x9gknd 8314 7 without without IN cord-010119-t1x9gknd 8314 8 a a DT cord-010119-t1x9gknd 8314 9 valid valid JJ cord-010119-t1x9gknd 8314 10 type type NN cord-010119-t1x9gknd 8314 11 and and CC cord-010119-t1x9gknd 8314 12 screen screen NN cord-010119-t1x9gknd 8314 13 . . . cord-010119-t1x9gknd 8315 1 Collectively collectively RB cord-010119-t1x9gknd 8315 2 termed term VBN cord-010119-t1x9gknd 8315 3 " " `` cord-010119-t1x9gknd 8315 4 emergently emergently RB cord-010119-t1x9gknd 8315 5 issued issue VBN cord-010119-t1x9gknd 8315 6 products product NNS cord-010119-t1x9gknd 8315 7 " " `` cord-010119-t1x9gknd 8315 8 they -PRON- PRP cord-010119-t1x9gknd 8315 9 are be VBP cord-010119-t1x9gknd 8315 10 issued issue VBN cord-010119-t1x9gknd 8315 11 as as IN cord-010119-t1x9gknd 8315 12 a a DT cord-010119-t1x9gknd 8315 13 bridge bridge NN cord-010119-t1x9gknd 8315 14 until until IN cord-010119-t1x9gknd 8315 15 pretransfusion pretransfusion NN cord-010119-t1x9gknd 8315 16 testing testing NN cord-010119-t1x9gknd 8315 17 is be VBZ cord-010119-t1x9gknd 8315 18 completed complete VBN cord-010119-t1x9gknd 8315 19 . . . cord-010119-t1x9gknd 8316 1 This this DT cord-010119-t1x9gknd 8316 2 study study NN cord-010119-t1x9gknd 8316 3 evaluated evaluate VBD cord-010119-t1x9gknd 8316 4 the the DT cord-010119-t1x9gknd 8316 5 utilization utilization NN cord-010119-t1x9gknd 8316 6 and and CC cord-010119-t1x9gknd 8316 7 wastage wastage NN cord-010119-t1x9gknd 8316 8 rates rate NNS cord-010119-t1x9gknd 8316 9 of of IN cord-010119-t1x9gknd 8316 10 blood blood NN cord-010119-t1x9gknd 8316 11 products product NNS cord-010119-t1x9gknd 8316 12 during during IN cord-010119-t1x9gknd 8316 13 pregnancy pregnancy NN cord-010119-t1x9gknd 8316 14 - - HYPH cord-010119-t1x9gknd 8316 15 related relate VBN cord-010119-t1x9gknd 8316 16 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8316 17 where where WRB cord-010119-t1x9gknd 8316 18 the the DT cord-010119-t1x9gknd 8316 19 first first JJ cord-010119-t1x9gknd 8316 20 products product NNS cord-010119-t1x9gknd 8316 21 issued issue VBN cord-010119-t1x9gknd 8316 22 were be VBD cord-010119-t1x9gknd 8316 23 emergently emergently RB cord-010119-t1x9gknd 8316 24 issued issue VBN cord-010119-t1x9gknd 8316 25 . . . cord-010119-t1x9gknd 8317 1 Study Study NNP cord-010119-t1x9gknd 8317 2 Design Design NNP cord-010119-t1x9gknd 8317 3 / / SYM cord-010119-t1x9gknd 8317 4 Methods method NNS cord-010119-t1x9gknd 8317 5 : : : cord-010119-t1x9gknd 8318 1 A a DT cord-010119-t1x9gknd 8318 2 list list NN cord-010119-t1x9gknd 8318 3 of of IN cord-010119-t1x9gknd 8318 4 patients patient NNS cord-010119-t1x9gknd 8318 5 on on IN cord-010119-t1x9gknd 8318 6 whom whom WP cord-010119-t1x9gknd 8318 7 blood blood NN cord-010119-t1x9gknd 8318 8 products product NNS cord-010119-t1x9gknd 8318 9 had have VBD cord-010119-t1x9gknd 8318 10 been be VBN cord-010119-t1x9gknd 8318 11 emergently emergently RB cord-010119-t1x9gknd 8318 12 issued issue VBN cord-010119-t1x9gknd 8318 13 between between IN cord-010119-t1x9gknd 8318 14 January January NNP cord-010119-t1x9gknd 8318 15 1 1 CD cord-010119-t1x9gknd 8318 16 , , , cord-010119-t1x9gknd 8318 17 2013 2013 CD cord-010119-t1x9gknd 8318 18 and and CC cord-010119-t1x9gknd 8318 19 March March NNP cord-010119-t1x9gknd 8318 20 28 28 CD cord-010119-t1x9gknd 8318 21 , , , cord-010119-t1x9gknd 8318 22 2017 2017 CD cord-010119-t1x9gknd 8318 23 was be VBD cord-010119-t1x9gknd 8318 24 obtained obtain VBN cord-010119-t1x9gknd 8318 25 from from IN cord-010119-t1x9gknd 8318 26 the the DT cord-010119-t1x9gknd 8318 27 blood blood NN cord-010119-t1x9gknd 8318 28 bank bank NN cord-010119-t1x9gknd 8318 29 at at IN cord-010119-t1x9gknd 8318 30 a a DT cord-010119-t1x9gknd 8318 31 regional regional JJ cord-010119-t1x9gknd 8318 32 maternity maternity NN cord-010119-t1x9gknd 8318 33 care care NN cord-010119-t1x9gknd 8318 34 hospital hospital NN cord-010119-t1x9gknd 8318 35 . . . cord-010119-t1x9gknd 8319 1 Patients patient NNS cord-010119-t1x9gknd 8319 2 who who WP cord-010119-t1x9gknd 8319 3 were be VBD cord-010119-t1x9gknd 8319 4 not not RB cord-010119-t1x9gknd 8319 5 experiencing experience VBG cord-010119-t1x9gknd 8319 6 a a DT cord-010119-t1x9gknd 8319 7 pregnancy pregnancy NN cord-010119-t1x9gknd 8319 8 - - HYPH cord-010119-t1x9gknd 8319 9 related relate VBN cord-010119-t1x9gknd 8319 10 bleed bleed NN cord-010119-t1x9gknd 8319 11 ( ( -LRB- cord-010119-t1x9gknd 8319 12 e.g. e.g. RB cord-010119-t1x9gknd 8319 13 , , , cord-010119-t1x9gknd 8319 14 postpartum postpartum NN cord-010119-t1x9gknd 8319 15 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8319 16 or or CC cord-010119-t1x9gknd 8319 17 bleeding bleeding NN cord-010119-t1x9gknd 8319 18 relating relate VBG cord-010119-t1x9gknd 8319 19 to to IN cord-010119-t1x9gknd 8319 20 a a DT cord-010119-t1x9gknd 8319 21 complication complication NN cord-010119-t1x9gknd 8319 22 of of IN cord-010119-t1x9gknd 8319 23 pregnancy pregnancy NN cord-010119-t1x9gknd 8319 24 such such JJ cord-010119-t1x9gknd 8319 25 as as IN cord-010119-t1x9gknd 8319 26 a a DT cord-010119-t1x9gknd 8319 27 ruptured rupture VBN cord-010119-t1x9gknd 8319 28 ectopic ectopic JJ cord-010119-t1x9gknd 8319 29 pregnancy pregnancy NN cord-010119-t1x9gknd 8319 30 or or CC cord-010119-t1x9gknd 8319 31 bleeding bleed VBG cord-010119-t1x9gknd 8319 32 post post NN cord-010119-t1x9gknd 8319 33 spontaneous spontaneous JJ cord-010119-t1x9gknd 8319 34 or or CC cord-010119-t1x9gknd 8319 35 therapeutic therapeutic JJ cord-010119-t1x9gknd 8319 36 abortion abortion NN cord-010119-t1x9gknd 8319 37 ) ) -RRB- cord-010119-t1x9gknd 8319 38 were be VBD cord-010119-t1x9gknd 8319 39 excluded exclude VBN cord-010119-t1x9gknd 8319 40 . . . cord-010119-t1x9gknd 8320 1 The the DT cord-010119-t1x9gknd 8320 2 total total JJ cord-010119-t1x9gknd 8320 3 number number NN cord-010119-t1x9gknd 8320 4 of of IN cord-010119-t1x9gknd 8320 5 products product NNS cord-010119-t1x9gknd 8320 6 ( ( -LRB- cord-010119-t1x9gknd 8320 7 emergently emergently RB cord-010119-t1x9gknd 8320 8 issued issue VBN cord-010119-t1x9gknd 8320 9 plus plus CC cord-010119-t1x9gknd 8320 10 crossmatched crossmatche VBN cord-010119-t1x9gknd 8320 11 or or CC cord-010119-t1x9gknd 8320 12 non non JJ cord-010119-t1x9gknd 8320 13 - - JJ cord-010119-t1x9gknd 8320 14 emergently emergently RB cord-010119-t1x9gknd 8320 15 issued issue VBN cord-010119-t1x9gknd 8320 16 products product NNS cord-010119-t1x9gknd 8320 17 ) ) -RRB- cord-010119-t1x9gknd 8320 18 that that WDT cord-010119-t1x9gknd 8320 19 were be VBD cord-010119-t1x9gknd 8320 20 transfused transfuse VBN cord-010119-t1x9gknd 8320 21 , , , cord-010119-t1x9gknd 8320 22 returned return VBD cord-010119-t1x9gknd 8320 23 back back RB cord-010119-t1x9gknd 8320 24 into into IN cord-010119-t1x9gknd 8320 25 the the DT cord-010119-t1x9gknd 8320 26 blood blood NN cord-010119-t1x9gknd 8320 27 bank bank NN cord-010119-t1x9gknd 8320 28 's 's POS cord-010119-t1x9gknd 8320 29 inventory inventory NN cord-010119-t1x9gknd 8320 30 , , , cord-010119-t1x9gknd 8320 31 and and CC cord-010119-t1x9gknd 8320 32 wasted waste VBN cord-010119-t1x9gknd 8320 33 within within IN cord-010119-t1x9gknd 8320 34 6 6 CD cord-010119-t1x9gknd 8320 35 hours hour NNS cord-010119-t1x9gknd 8320 36 of of IN cord-010119-t1x9gknd 8320 37 the the DT cord-010119-t1x9gknd 8320 38 first first JJ cord-010119-t1x9gknd 8320 39 emergently emergently RB cord-010119-t1x9gknd 8320 40 issued issue VBN cord-010119-t1x9gknd 8320 41 products product NNS cord-010119-t1x9gknd 8320 42 were be VBD cord-010119-t1x9gknd 8320 43 enumerated enumerate VBN cord-010119-t1x9gknd 8320 44 . . . cord-010119-t1x9gknd 8321 1 Apheresis Apheresis NNP cord-010119-t1x9gknd 8321 2 PLT PLT NNP cord-010119-t1x9gknd 8321 3 units unit NNS cord-010119-t1x9gknd 8321 4 were be VBD cord-010119-t1x9gknd 8321 5 multiplied multiply VBN cord-010119-t1x9gknd 8321 6 by by IN cord-010119-t1x9gknd 8321 7 5 5 CD cord-010119-t1x9gknd 8321 8 and and CC cord-010119-t1x9gknd 8321 9 added add VBD cord-010119-t1x9gknd 8321 10 to to IN cord-010119-t1x9gknd 8321 11 the the DT cord-010119-t1x9gknd 8321 12 number number NN cord-010119-t1x9gknd 8321 13 of of IN cord-010119-t1x9gknd 8321 14 individual individual JJ cord-010119-t1x9gknd 8321 15 whole whole JJ cord-010119-t1x9gknd 8321 16 blood blood NN cord-010119-t1x9gknd 8321 17 PLTs plt NNS cord-010119-t1x9gknd 8321 18 ; ; : cord-010119-t1x9gknd 8321 19 apheresis apheresis NN cord-010119-t1x9gknd 8321 20 plasma plasma NN cord-010119-t1x9gknd 8321 21 units unit NNS cord-010119-t1x9gknd 8321 22 were be VBD cord-010119-t1x9gknd 8321 23 multiplied multiply VBN cord-010119-t1x9gknd 8321 24 by by IN cord-010119-t1x9gknd 8321 25 2 2 CD cord-010119-t1x9gknd 8321 26 and and CC cord-010119-t1x9gknd 8321 27 added add VBN cord-010119-t1x9gknd 8321 28 to to IN cord-010119-t1x9gknd 8321 29 the the DT cord-010119-t1x9gknd 8321 30 number number NN cord-010119-t1x9gknd 8321 31 of of IN cord-010119-t1x9gknd 8321 32 whole whole JJ cord-010119-t1x9gknd 8321 33 blood blood NN cord-010119-t1x9gknd 8321 34 plasma plasma NN cord-010119-t1x9gknd 8321 35 units unit NNS cord-010119-t1x9gknd 8321 36 . . . cord-010119-t1x9gknd 8322 1 Results result NNS cord-010119-t1x9gknd 8322 2 / / SYM cord-010119-t1x9gknd 8322 3 Findings finding NNS cord-010119-t1x9gknd 8322 4 : : : cord-010119-t1x9gknd 8323 1 Seventy seventy CD cord-010119-t1x9gknd 8323 2 women woman NNS cord-010119-t1x9gknd 8323 3 who who WP cord-010119-t1x9gknd 8323 4 received receive VBD cord-010119-t1x9gknd 8323 5 emergently emergently RB cord-010119-t1x9gknd 8323 6 issued issue VBN cord-010119-t1x9gknd 8323 7 blood blood NN cord-010119-t1x9gknd 8323 8 products product NNS cord-010119-t1x9gknd 8323 9 during during IN cord-010119-t1x9gknd 8323 10 a a DT cord-010119-t1x9gknd 8323 11 pregnancy pregnancy NN cord-010119-t1x9gknd 8323 12 - - HYPH cord-010119-t1x9gknd 8323 13 related relate VBN cord-010119-t1x9gknd 8323 14 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8323 15 were be VBD cord-010119-t1x9gknd 8323 16 identified identify VBN cord-010119-t1x9gknd 8323 17 . . . cord-010119-t1x9gknd 8324 1 Average average JJ cord-010119-t1x9gknd 8324 2 age age NN cord-010119-t1x9gknd 8324 3 was be VBD cord-010119-t1x9gknd 8324 4 31 31 CD cord-010119-t1x9gknd 8324 5 . . . cord-010119-t1x9gknd 8325 1 The the DT cord-010119-t1x9gknd 8325 2 majority majority NN cord-010119-t1x9gknd 8325 3 of of IN cord-010119-t1x9gknd 8325 4 these these DT cord-010119-t1x9gknd 8325 5 patients patient NNS cord-010119-t1x9gknd 8325 6 with with IN cord-010119-t1x9gknd 8325 7 pregnancy pregnancy NN cord-010119-t1x9gknd 8325 8 - - HYPH cord-010119-t1x9gknd 8325 9 related relate VBN cord-010119-t1x9gknd 8325 10 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8325 11 who who WP cord-010119-t1x9gknd 8325 12 received receive VBD cord-010119-t1x9gknd 8325 13 at at IN cord-010119-t1x9gknd 8325 14 least least RBS cord-010119-t1x9gknd 8325 15 one one CD cord-010119-t1x9gknd 8325 16 unit unit NN cord-010119-t1x9gknd 8325 17 of of IN cord-010119-t1x9gknd 8325 18 emergently emergently RB cord-010119-t1x9gknd 8325 19 issued issue VBN cord-010119-t1x9gknd 8325 20 blood blood NN cord-010119-t1x9gknd 8325 21 products product NNS cord-010119-t1x9gknd 8325 22 received receive VBN cord-010119-t1x9gknd 8325 23 at at IN cord-010119-t1x9gknd 8325 24 least least RBS cord-010119-t1x9gknd 8325 25 one one CD cord-010119-t1x9gknd 8325 26 unit unit NN cord-010119-t1x9gknd 8325 27 of of IN cord-010119-t1x9gknd 8325 28 the the DT cord-010119-t1x9gknd 8325 29 product product NN cord-010119-t1x9gknd 8325 30 that that WDT cord-010119-t1x9gknd 8325 31 was be VBD cord-010119-t1x9gknd 8325 32 issued issue VBN cord-010119-t1x9gknd 8325 33 to to IN cord-010119-t1x9gknd 8325 34 them -PRON- PRP cord-010119-t1x9gknd 8325 35 and and CC cord-010119-t1x9gknd 8325 36 few few JJ cord-010119-t1x9gknd 8325 37 units unit NNS cord-010119-t1x9gknd 8325 38 were be VBD cord-010119-t1x9gknd 8325 39 wasted waste VBN cord-010119-t1x9gknd 8325 40 . . . cord-010119-t1x9gknd 8326 1 That that DT cord-010119-t1x9gknd 8326 2 PLT PLT NNP cord-010119-t1x9gknd 8326 3 wastage wastage NN cord-010119-t1x9gknd 8326 4 was be VBD cord-010119-t1x9gknd 8326 5 higher high JJR cord-010119-t1x9gknd 8326 6 than than IN cord-010119-t1x9gknd 8326 7 the the DT cord-010119-t1x9gknd 8326 8 other other JJ cord-010119-t1x9gknd 8326 9 products product NNS cord-010119-t1x9gknd 8326 10 was be VBD cord-010119-t1x9gknd 8326 11 likely likely JJ cord-010119-t1x9gknd 8326 12 due due IN cord-010119-t1x9gknd 8326 13 to to IN cord-010119-t1x9gknd 8326 14 the the DT cord-010119-t1x9gknd 8326 15 4-hour 4-hour JJ cord-010119-t1x9gknd 8326 16 post post JJ cord-010119-t1x9gknd 8326 17 - - JJ cord-010119-t1x9gknd 8326 18 pooling pooling JJ cord-010119-t1x9gknd 8326 19 room room NN cord-010119-t1x9gknd 8326 20 temperature temperature NN cord-010119-t1x9gknd 8326 21 shelf shelf NN cord-010119-t1x9gknd 8326 22 life life NN cord-010119-t1x9gknd 8326 23 . . . cord-010119-t1x9gknd 8327 1 Keeping keep VBG cord-010119-t1x9gknd 8327 2 wastage wastage NN cord-010119-t1x9gknd 8327 3 rates rate NNS cord-010119-t1x9gknd 8327 4 low low JJ cord-010119-t1x9gknd 8327 5 while while IN cord-010119-t1x9gknd 8327 6 meeting meet VBG cord-010119-t1x9gknd 8327 7 the the DT cord-010119-t1x9gknd 8327 8 clinical clinical JJ cord-010119-t1x9gknd 8327 9 needs need NNS cord-010119-t1x9gknd 8327 10 of of IN cord-010119-t1x9gknd 8327 11 these these DT cord-010119-t1x9gknd 8327 12 patients patient NNS cord-010119-t1x9gknd 8327 13 is be VBZ cord-010119-t1x9gknd 8327 14 the the DT cord-010119-t1x9gknd 8327 15 ideal ideal JJ cord-010119-t1x9gknd 8327 16 situation situation NN cord-010119-t1x9gknd 8327 17 for for IN cord-010119-t1x9gknd 8327 18 the the DT cord-010119-t1x9gknd 8327 19 blood blood NN cord-010119-t1x9gknd 8327 20 bank bank NN cord-010119-t1x9gknd 8327 21 . . . cord-010119-t1x9gknd 8327 22 . . . cord-010119-t1x9gknd 8328 1 Patient patient JJ cord-010119-t1x9gknd 8328 2 blood blood NN cord-010119-t1x9gknd 8328 3 platelets platelet NNS cord-010119-t1x9gknd 8328 4 were be VBD cord-010119-t1x9gknd 8328 5 higher high JJR cord-010119-t1x9gknd 8328 6 before before IN cord-010119-t1x9gknd 8328 7 prophylactic prophylactic JJ cord-010119-t1x9gknd 8328 8 than than IN cord-010119-t1x9gknd 8328 9 therapeutic therapeutic JJ cord-010119-t1x9gknd 8328 10 transfusions transfusion NNS cord-010119-t1x9gknd 8329 1 ( ( -LRB- cord-010119-t1x9gknd 8329 2 18[10 18[10 CD cord-010119-t1x9gknd 8329 3 9 9 CD cord-010119-t1x9gknd 8329 4 /l /l NN cord-010119-t1x9gknd 8329 5 vs. vs. NN cord-010119-t1x9gknd 8329 6 14[10 14[10 CD cord-010119-t1x9gknd 8329 7 9 9 CD cord-010119-t1x9gknd 8329 8 /l /l NN cord-010119-t1x9gknd 8329 9 , , , cord-010119-t1x9gknd 8329 10 p50.029 p50.029 NN cord-010119-t1x9gknd 8329 11 ) ) -RRB- cord-010119-t1x9gknd 8329 12 . . . cord-010119-t1x9gknd 8330 1 There there EX cord-010119-t1x9gknd 8330 2 were be VBD cord-010119-t1x9gknd 8330 3 no no DT cord-010119-t1x9gknd 8330 4 significant significant JJ cord-010119-t1x9gknd 8330 5 differences difference NNS cord-010119-t1x9gknd 8330 6 in in IN cord-010119-t1x9gknd 8330 7 the the DT cord-010119-t1x9gknd 8330 8 frequency frequency NN cord-010119-t1x9gknd 8330 9 of of IN cord-010119-t1x9gknd 8330 10 effective effective JJ cord-010119-t1x9gknd 8330 11 therapeutic therapeutic JJ cord-010119-t1x9gknd 8331 1 ( ( -LRB- cord-010119-t1x9gknd 8331 2 55 55 CD cord-010119-t1x9gknd 8331 3 % % NN cord-010119-t1x9gknd 8331 4 vs. vs. IN cord-010119-t1x9gknd 8331 5 72 72 CD cord-010119-t1x9gknd 8331 6 % % NN cord-010119-t1x9gknd 8331 7 , , , cord-010119-t1x9gknd 8331 8 p50.1 p50.1 NN cord-010119-t1x9gknd 8331 9 ) ) -RRB- cord-010119-t1x9gknd 8331 10 and and CC cord-010119-t1x9gknd 8331 11 prophylactic prophylactic JJ cord-010119-t1x9gknd 8331 12 ( ( -LRB- cord-010119-t1x9gknd 8331 13 63 63 CD cord-010119-t1x9gknd 8331 14 % % NN cord-010119-t1x9gknd 8331 15 vs. vs. IN cord-010119-t1x9gknd 8331 16 54 54 CD cord-010119-t1x9gknd 8331 17 % % NN cord-010119-t1x9gknd 8331 18 , , , cord-010119-t1x9gknd 8331 19 p50.09 p50.09 JJ cord-010119-t1x9gknd 8331 20 ) ) -RRB- cord-010119-t1x9gknd 8331 21 transfusions transfusion NNS cord-010119-t1x9gknd 8331 22 between between IN cord-010119-t1x9gknd 8331 23 the the DT cord-010119-t1x9gknd 8331 24 PRCs PRCs NNPS cord-010119-t1x9gknd 8331 25 and and CC cord-010119-t1x9gknd 8331 26 25GyPCs 25gypcs CD cord-010119-t1x9gknd 8331 27 . . . cord-010119-t1x9gknd 8332 1 We -PRON- PRP cord-010119-t1x9gknd 8332 2 did do VBD cord-010119-t1x9gknd 8332 3 not not RB cord-010119-t1x9gknd 8332 4 find find VB cord-010119-t1x9gknd 8332 5 significant significant JJ cord-010119-t1x9gknd 8332 6 differences difference NNS cord-010119-t1x9gknd 8332 7 between between IN cord-010119-t1x9gknd 8332 8 PRCs PRCs NNPS cord-010119-t1x9gknd 8332 9 and and CC cord-010119-t1x9gknd 8332 10 25GyPCs 25gypcs CD cord-010119-t1x9gknd 8332 11 in in IN cord-010119-t1x9gknd 8332 12 CCI1 CCI1 NNP cord-010119-t1x9gknd 8332 13 after after IN cord-010119-t1x9gknd 8332 14 prophylactic prophylactic JJ cord-010119-t1x9gknd 8332 15 ( ( -LRB- cord-010119-t1x9gknd 8332 16 16.0 16.0 CD cord-010119-t1x9gknd 8332 17 6 6 CD cord-010119-t1x9gknd 8332 18 7.1 7.1 CD cord-010119-t1x9gknd 8332 19 vs. vs. IN cord-010119-t1x9gknd 8332 20 19.2 19.2 CD cord-010119-t1x9gknd 8332 21 6 6 CD cord-010119-t1x9gknd 8332 22 8.7 8.7 CD cord-010119-t1x9gknd 8332 23 ) ) -RRB- cord-010119-t1x9gknd 8332 24 and and CC cord-010119-t1x9gknd 8332 25 therapeutic therapeutic JJ cord-010119-t1x9gknd 8332 26 ( ( -LRB- cord-010119-t1x9gknd 8332 27 11.3 11.3 CD cord-010119-t1x9gknd 8332 28 6 6 CD cord-010119-t1x9gknd 8332 29 9.0 9.0 CD cord-010119-t1x9gknd 8332 30 vs. vs. IN cord-010119-t1x9gknd 8332 31 11.8 11.8 CD cord-010119-t1x9gknd 8332 32 6 6 CD cord-010119-t1x9gknd 8332 33 5.8 5.8 CD cord-010119-t1x9gknd 8332 34 ) ) -RRB- cord-010119-t1x9gknd 8332 35 transfusions transfusion NNS cord-010119-t1x9gknd 8332 36 , , , cord-010119-t1x9gknd 8332 37 in in IN cord-010119-t1x9gknd 8332 38 CC24 CC24 NNP cord-010119-t1x9gknd 8332 39 after after IN cord-010119-t1x9gknd 8332 40 prophylactic prophylactic JJ cord-010119-t1x9gknd 8332 41 ( ( -LRB- cord-010119-t1x9gknd 8332 42 20.0 20.0 CD cord-010119-t1x9gknd 8332 43 6 6 CD cord-010119-t1x9gknd 8332 44 9.2 9.2 CD cord-010119-t1x9gknd 8332 45 vs. vs. NN cord-010119-t1x9gknd 8332 46 22.5 22.5 CD cord-010119-t1x9gknd 8332 47 6 6 CD cord-010119-t1x9gknd 8332 48 12.8 12.8 CD cord-010119-t1x9gknd 8332 49 ) ) -RRB- cord-010119-t1x9gknd 8332 50 and and CC cord-010119-t1x9gknd 8332 51 therapeutic therapeutic JJ cord-010119-t1x9gknd 8332 52 ( ( -LRB- cord-010119-t1x9gknd 8332 53 13.3 13.3 CD cord-010119-t1x9gknd 8332 54 6 6 CD cord-010119-t1x9gknd 8332 55 8.9 8.9 CD cord-010119-t1x9gknd 8332 56 vs. vs. NN cord-010119-t1x9gknd 8332 57 13.9 13.9 CD cord-010119-t1x9gknd 8332 58 6 6 CD cord-010119-t1x9gknd 8332 59 8 8 CD cord-010119-t1x9gknd 8332 60 . . . cord-010119-t1x9gknd 8332 61 ) ) -RRB- cord-010119-t1x9gknd 8332 62 transfusions transfusion NNS cord-010119-t1x9gknd 8332 63 . . . cord-010119-t1x9gknd 8333 1 There there EX cord-010119-t1x9gknd 8333 2 were be VBD cord-010119-t1x9gknd 8333 3 no no DT cord-010119-t1x9gknd 8333 4 significant significant JJ cord-010119-t1x9gknd 8333 5 differences difference NNS cord-010119-t1x9gknd 8333 6 between between IN cord-010119-t1x9gknd 8333 7 PRCs PRCs NNPS cord-010119-t1x9gknd 8333 8 and and CC cord-010119-t1x9gknd 8333 9 25GyPCs 25gypcs CD cord-010119-t1x9gknd 8333 10 also also RB cord-010119-t1x9gknd 8333 11 in in IN cord-010119-t1x9gknd 8333 12 MA1 MA1 NNP cord-010119-t1x9gknd 8333 13 after after IN cord-010119-t1x9gknd 8333 14 prophylactic prophylactic JJ cord-010119-t1x9gknd 8333 15 ( ( -LRB- cord-010119-t1x9gknd 8333 16 62.2 62.2 CD cord-010119-t1x9gknd 8333 17 6 6 CD cord-010119-t1x9gknd 8333 18 8.5 8.5 CD cord-010119-t1x9gknd 8333 19 vs. vs. NN cord-010119-t1x9gknd 8333 20 60 60 CD cord-010119-t1x9gknd 8333 21 6 6 CD cord-010119-t1x9gknd 8333 22 8.5 8.5 CD cord-010119-t1x9gknd 8333 23 , , , cord-010119-t1x9gknd 8333 24 p50.7 p50.7 CD cord-010119-t1x9gknd 8333 25 ) ) -RRB- cord-010119-t1x9gknd 8333 26 and and CC cord-010119-t1x9gknd 8333 27 therapeutic therapeutic JJ cord-010119-t1x9gknd 8333 28 ( ( -LRB- cord-010119-t1x9gknd 8333 29 61.3 61.3 CD cord-010119-t1x9gknd 8333 30 6 6 CD cord-010119-t1x9gknd 8333 31 9.9 9.9 CD cord-010119-t1x9gknd 8333 32 vs. vs. IN cord-010119-t1x9gknd 8333 33 60.9 60.9 CD cord-010119-t1x9gknd 8333 34 6 6 CD cord-010119-t1x9gknd 8333 35 12.7 12.7 CD cord-010119-t1x9gknd 8333 36 , , , cord-010119-t1x9gknd 8333 37 p50.08 p50.08 NNP cord-010119-t1x9gknd 8333 38 ) ) -RRB- cord-010119-t1x9gknd 8333 39 PC pc NN cord-010119-t1x9gknd 8333 40 transfusions transfusion NNS cord-010119-t1x9gknd 8333 41 . . . cord-010119-t1x9gknd 8334 1 Reduction reduction NN cord-010119-t1x9gknd 8334 2 of of IN cord-010119-t1x9gknd 8334 3 the the DT cord-010119-t1x9gknd 8334 4 severity severity NN cord-010119-t1x9gknd 8334 5 of of IN cord-010119-t1x9gknd 8334 6 bleeds bleed NNS cord-010119-t1x9gknd 8334 7 was be VBD cord-010119-t1x9gknd 8334 8 obtained obtain VBN cord-010119-t1x9gknd 8334 9 in in IN cord-010119-t1x9gknd 8334 10 78 78 CD cord-010119-t1x9gknd 8334 11 ( ( -LRB- cord-010119-t1x9gknd 8334 12 86 86 CD cord-010119-t1x9gknd 8334 13 % % NN cord-010119-t1x9gknd 8334 14 ) ) -RRB- cord-010119-t1x9gknd 8334 15 of of IN cord-010119-t1x9gknd 8334 16 the the DT cord-010119-t1x9gknd 8334 17 91 91 CD cord-010119-t1x9gknd 8334 18 cases case NNS cord-010119-t1x9gknd 8334 19 after after IN cord-010119-t1x9gknd 8334 20 PRPC PRPC NNP cord-010119-t1x9gknd 8334 21 transfusions transfusion NNS cord-010119-t1x9gknd 8334 22 and and CC cord-010119-t1x9gknd 8334 23 in in IN cord-010119-t1x9gknd 8334 24 51 51 CD cord-010119-t1x9gknd 8334 25 ( ( -LRB- cord-010119-t1x9gknd 8334 26 84 84 CD cord-010119-t1x9gknd 8334 27 % % NN cord-010119-t1x9gknd 8334 28 ) ) -RRB- cord-010119-t1x9gknd 8334 29 of of IN cord-010119-t1x9gknd 8334 30 61 61 CD cord-010119-t1x9gknd 8334 31 cases case NNS cord-010119-t1x9gknd 8334 32 after after IN cord-010119-t1x9gknd 8334 33 25GyPC 25gypc CD cord-010119-t1x9gknd 8334 34 transfusions transfusion NNS cord-010119-t1x9gknd 8334 35 . . . cord-010119-t1x9gknd 8335 1 There there EX cord-010119-t1x9gknd 8335 2 were be VBD cord-010119-t1x9gknd 8335 3 no no DT cord-010119-t1x9gknd 8335 4 significant significant JJ cord-010119-t1x9gknd 8335 5 differences difference NNS cord-010119-t1x9gknd 8335 6 in in IN cord-010119-t1x9gknd 8335 7 the the DT cord-010119-t1x9gknd 8335 8 frequency frequency NN cord-010119-t1x9gknd 8335 9 of of IN cord-010119-t1x9gknd 8335 10 adverse adverse JJ cord-010119-t1x9gknd 8335 11 post post JJ cord-010119-t1x9gknd 8335 12 - - JJ cord-010119-t1x9gknd 8335 13 transfusion transfusion JJ cord-010119-t1x9gknd 8335 14 reactions reaction NNS cord-010119-t1x9gknd 8335 15 between between IN cord-010119-t1x9gknd 8335 16 the the DT cord-010119-t1x9gknd 8335 17 groups group NNS cord-010119-t1x9gknd 8335 18 ( ( -LRB- cord-010119-t1x9gknd 8335 19 respectively respectively RB cord-010119-t1x9gknd 8335 20 , , , cord-010119-t1x9gknd 8335 21 3 3 CD cord-010119-t1x9gknd 8335 22 and and CC cord-010119-t1x9gknd 8335 23 2 2 CD cord-010119-t1x9gknd 8335 24 cases case NNS cord-010119-t1x9gknd 8335 25 ) ) -RRB- cord-010119-t1x9gknd 8335 26 . . . cord-010119-t1x9gknd 8336 1 Background Background NNP cord-010119-t1x9gknd 8336 2 / / SYM cord-010119-t1x9gknd 8336 3 Case Case NNP cord-010119-t1x9gknd 8336 4 Studies Studies NNPS cord-010119-t1x9gknd 8336 5 : : : cord-010119-t1x9gknd 8337 1 An an DT cord-010119-t1x9gknd 8337 2 ' ' `` cord-010119-t1x9gknd 8337 3 end end NN cord-010119-t1x9gknd 8337 4 - - HYPH cord-010119-t1x9gknd 8337 5 to to IN cord-010119-t1x9gknd 8337 6 - - HYPH cord-010119-t1x9gknd 8337 7 end end NN cord-010119-t1x9gknd 8337 8 ' ' '' cord-010119-t1x9gknd 8337 9 electronic electronic JJ cord-010119-t1x9gknd 8337 10 transfusion transfusion NN cord-010119-t1x9gknd 8337 11 management management NN cord-010119-t1x9gknd 8337 12 process process NN cord-010119-t1x9gknd 8337 13 including include VBG cord-010119-t1x9gknd 8337 14 a a DT cord-010119-t1x9gknd 8337 15 bedside bedside NN cord-010119-t1x9gknd 8337 16 administration administration NN cord-010119-t1x9gknd 8337 17 system system NN cord-010119-t1x9gknd 8337 18 was be VBD cord-010119-t1x9gknd 8337 19 developed develop VBN cord-010119-t1x9gknd 8337 20 and and CC cord-010119-t1x9gknd 8337 21 implemented implement VBN cord-010119-t1x9gknd 8337 22 in in IN cord-010119-t1x9gknd 8337 23 this this DT cord-010119-t1x9gknd 8337 24 large large JJ cord-010119-t1x9gknd 8337 25 multi multi JJ cord-010119-t1x9gknd 8337 26 - - JJ cord-010119-t1x9gknd 8337 27 site site JJ cord-010119-t1x9gknd 8337 28 academic academic JJ cord-010119-t1x9gknd 8337 29 center center NN cord-010119-t1x9gknd 8337 30 in in IN cord-010119-t1x9gknd 8337 31 2006 2006 CD cord-010119-t1x9gknd 8337 32 . . . cord-010119-t1x9gknd 8338 1 It -PRON- PRP cord-010119-t1x9gknd 8338 2 enables enable VBZ cord-010119-t1x9gknd 8338 3 the the DT cord-010119-t1x9gknd 8338 4 safe safe JJ cord-010119-t1x9gknd 8338 5 administration administration NN cord-010119-t1x9gknd 8338 6 of of IN cord-010119-t1x9gknd 8338 7 blood blood NN cord-010119-t1x9gknd 8338 8 components component NNS cord-010119-t1x9gknd 8338 9 at at IN cord-010119-t1x9gknd 8338 10 the the DT cord-010119-t1x9gknd 8338 11 patient patient JJ cord-010119-t1x9gknd 8338 12 bedside bedside NN cord-010119-t1x9gknd 8338 13 and and CC cord-010119-t1x9gknd 8338 14 provides provide VBZ cord-010119-t1x9gknd 8338 15 an an DT cord-010119-t1x9gknd 8338 16 audit audit NN cord-010119-t1x9gknd 8338 17 trail trail NN cord-010119-t1x9gknd 8338 18 for for IN cord-010119-t1x9gknd 8338 19 all all DT cord-010119-t1x9gknd 8338 20 blood blood NN cord-010119-t1x9gknd 8338 21 components component NNS cord-010119-t1x9gknd 8338 22 . . . cord-010119-t1x9gknd 8339 1 An an DT cord-010119-t1x9gknd 8339 2 error error NN cord-010119-t1x9gknd 8339 3 was be VBD cord-010119-t1x9gknd 8339 4 identified identify VBN cord-010119-t1x9gknd 8339 5 in in IN cord-010119-t1x9gknd 8339 6 the the DT cord-010119-t1x9gknd 8339 7 electronic electronic JJ cord-010119-t1x9gknd 8339 8 bedside bedside NN cord-010119-t1x9gknd 8339 9 transfusion transfusion NN cord-010119-t1x9gknd 8339 10 process process NN cord-010119-t1x9gknd 8339 11 which which WDT cord-010119-t1x9gknd 8339 12 was be VBD cord-010119-t1x9gknd 8339 13 reported report VBN cord-010119-t1x9gknd 8339 14 to to IN cord-010119-t1x9gknd 8339 15 our -PRON- PRP$ cord-010119-t1x9gknd 8339 16 national national JJ cord-010119-t1x9gknd 8339 17 hemovigilance hemovigilance NN cord-010119-t1x9gknd 8339 18 scheme scheme NN cord-010119-t1x9gknd 8339 19 in in IN cord-010119-t1x9gknd 8339 20 2014 2014 CD cord-010119-t1x9gknd 8339 21 under under IN cord-010119-t1x9gknd 8339 22 the the DT cord-010119-t1x9gknd 8339 23 category category NN cord-010119-t1x9gknd 8339 24 ' ' '' cord-010119-t1x9gknd 8339 25 errors error NNS cord-010119-t1x9gknd 8339 26 relating relate VBG cord-010119-t1x9gknd 8339 27 to to IN cord-010119-t1x9gknd 8339 28 information information NN cord-010119-t1x9gknd 8339 29 technology technology NN cord-010119-t1x9gknd 8339 30 ' ' '' cord-010119-t1x9gknd 8339 31 . . . cord-010119-t1x9gknd 8340 1 This this DT cord-010119-t1x9gknd 8340 2 error error NN cord-010119-t1x9gknd 8340 3 was be VBD cord-010119-t1x9gknd 8340 4 the the DT cord-010119-t1x9gknd 8340 5 incorrect incorrect JJ cord-010119-t1x9gknd 8340 6 use use NN cord-010119-t1x9gknd 8340 7 of of IN cord-010119-t1x9gknd 8340 8 the the DT cord-010119-t1x9gknd 8340 9 emergency emergency NN cord-010119-t1x9gknd 8340 10 transfusion transfusion NN cord-010119-t1x9gknd 8340 11 process process NN cord-010119-t1x9gknd 8340 12 for for IN cord-010119-t1x9gknd 8340 13 non non JJ cord-010119-t1x9gknd 8340 14 - - JJ cord-010119-t1x9gknd 8340 15 emergency emergency JJ cord-010119-t1x9gknd 8340 16 transfusions transfusion NNS cord-010119-t1x9gknd 8340 17 . . . cord-010119-t1x9gknd 8341 1 The the DT cord-010119-t1x9gknd 8341 2 standard standard JJ cord-010119-t1x9gknd 8341 3 ( ( -LRB- cord-010119-t1x9gknd 8341 4 non non JJ cord-010119-t1x9gknd 8341 5 - - JJ cord-010119-t1x9gknd 8341 6 emergency emergency JJ cord-010119-t1x9gknd 8341 7 ) ) -RRB- cord-010119-t1x9gknd 8341 8 process process NN cord-010119-t1x9gknd 8341 9 requires require VBZ cord-010119-t1x9gknd 8341 10 a a DT cord-010119-t1x9gknd 8341 11 scan scan NN cord-010119-t1x9gknd 8341 12 of of IN cord-010119-t1x9gknd 8341 13 the the DT cord-010119-t1x9gknd 8341 14 barcode barcode NN cord-010119-t1x9gknd 8341 15 on on IN cord-010119-t1x9gknd 8341 16 the the DT cord-010119-t1x9gknd 8341 17 patient patient NN cord-010119-t1x9gknd 8341 18 's 's POS cord-010119-t1x9gknd 8341 19 wristband wristband NN cord-010119-t1x9gknd 8341 20 containing contain VBG cord-010119-t1x9gknd 8341 21 their -PRON- PRP$ cord-010119-t1x9gknd 8341 22 identification identification NN cord-010119-t1x9gknd 8341 23 details detail NNS cord-010119-t1x9gknd 8341 24 which which WDT cord-010119-t1x9gknd 8341 25 is be VBZ cord-010119-t1x9gknd 8341 26 verified verify VBN cord-010119-t1x9gknd 8341 27 against against IN cord-010119-t1x9gknd 8341 28 the the DT cord-010119-t1x9gknd 8341 29 same same JJ cord-010119-t1x9gknd 8341 30 details detail NNS cord-010119-t1x9gknd 8341 31 from from IN cord-010119-t1x9gknd 8341 32 the the DT cord-010119-t1x9gknd 8341 33 barcode barcode NN cord-010119-t1x9gknd 8341 34 on on IN cord-010119-t1x9gknd 8341 35 the the DT cord-010119-t1x9gknd 8341 36 compatibility compatibility NN cord-010119-t1x9gknd 8341 37 label label NN cord-010119-t1x9gknd 8341 38 attached attach VBN cord-010119-t1x9gknd 8341 39 to to IN cord-010119-t1x9gknd 8341 40 the the DT cord-010119-t1x9gknd 8341 41 blood blood NN cord-010119-t1x9gknd 8341 42 bag bag NN cord-010119-t1x9gknd 8341 43 . . . cord-010119-t1x9gknd 8342 1 The the DT cord-010119-t1x9gknd 8342 2 emergency emergency NN cord-010119-t1x9gknd 8342 3 transfusion transfusion NN cord-010119-t1x9gknd 8342 4 option option NN cord-010119-t1x9gknd 8342 5 is be VBZ cord-010119-t1x9gknd 8342 6 only only RB cord-010119-t1x9gknd 8342 7 intended intend VBN cord-010119-t1x9gknd 8342 8 for for IN cord-010119-t1x9gknd 8342 9 use use NN cord-010119-t1x9gknd 8342 10 with with IN cord-010119-t1x9gknd 8342 11 ' ' '' cord-010119-t1x9gknd 8342 12 emergency emergency NN cord-010119-t1x9gknd 8342 13 group group NN cord-010119-t1x9gknd 8342 14 O o NN cord-010119-t1x9gknd 8342 15 RhD rhd NN cord-010119-t1x9gknd 8342 16 negative negative JJ cord-010119-t1x9gknd 8342 17 blood blood NN cord-010119-t1x9gknd 8342 18 units unit NNS cord-010119-t1x9gknd 8342 19 ' ' '' cord-010119-t1x9gknd 8342 20 which which WDT cord-010119-t1x9gknd 8342 21 , , , cord-010119-t1x9gknd 8342 22 unlike unlike IN cord-010119-t1x9gknd 8342 23 non non JJ cord-010119-t1x9gknd 8342 24 - - JJ cord-010119-t1x9gknd 8342 25 emergency emergency JJ cord-010119-t1x9gknd 8342 26 units unit NNS cord-010119-t1x9gknd 8342 27 allocated allocate VBN cord-010119-t1x9gknd 8342 28 to to IN cord-010119-t1x9gknd 8342 29 specific specific JJ cord-010119-t1x9gknd 8342 30 patients patient NNS cord-010119-t1x9gknd 8342 31 , , , cord-010119-t1x9gknd 8342 32 do do VBP cord-010119-t1x9gknd 8342 33 not not RB cord-010119-t1x9gknd 8342 34 have have VB cord-010119-t1x9gknd 8342 35 a a DT cord-010119-t1x9gknd 8342 36 compatibility compatibility NN cord-010119-t1x9gknd 8342 37 label label NN cord-010119-t1x9gknd 8342 38 . . . cord-010119-t1x9gknd 8343 1 The the DT cord-010119-t1x9gknd 8343 2 emergency emergency NN cord-010119-t1x9gknd 8343 3 transfusion transfusion NN cord-010119-t1x9gknd 8343 4 option option NN cord-010119-t1x9gknd 8343 5 skips skip VBZ cord-010119-t1x9gknd 8343 6 the the DT cord-010119-t1x9gknd 8343 7 compatibility compatibility NN cord-010119-t1x9gknd 8343 8 label label NN cord-010119-t1x9gknd 8343 9 barcode barcode NN cord-010119-t1x9gknd 8343 10 scan scan NN cord-010119-t1x9gknd 8343 11 as as IN cord-010119-t1x9gknd 8343 12 the the DT cord-010119-t1x9gknd 8343 13 emergency emergency NN cord-010119-t1x9gknd 8343 14 units unit NNS cord-010119-t1x9gknd 8343 15 can can MD cord-010119-t1x9gknd 8343 16 be be VB cord-010119-t1x9gknd 8343 17 transfused transfuse VBN cord-010119-t1x9gknd 8343 18 to to IN cord-010119-t1x9gknd 8343 19 any any DT cord-010119-t1x9gknd 8343 20 patient patient NN cord-010119-t1x9gknd 8343 21 needing need VBG cord-010119-t1x9gknd 8343 22 urgent urgent JJ cord-010119-t1x9gknd 8343 23 transfusion transfusion NN cord-010119-t1x9gknd 8343 24 . . . cord-010119-t1x9gknd 8344 1 It -PRON- PRP cord-010119-t1x9gknd 8344 2 was be VBD cord-010119-t1x9gknd 8344 3 found find VBN cord-010119-t1x9gknd 8344 4 that that IN cord-010119-t1x9gknd 8344 5 the the DT cord-010119-t1x9gknd 8344 6 emergency emergency NN cord-010119-t1x9gknd 8344 7 blood blood NN cord-010119-t1x9gknd 8344 8 option option NN cord-010119-t1x9gknd 8344 9 was be VBD cord-010119-t1x9gknd 8344 10 being be VBG cord-010119-t1x9gknd 8344 11 misused misuse VBN cord-010119-t1x9gknd 8344 12 for for IN cord-010119-t1x9gknd 8344 13 non non JJ cord-010119-t1x9gknd 8344 14 - - JJ cord-010119-t1x9gknd 8344 15 emergency emergency JJ cord-010119-t1x9gknd 8344 16 transfusions transfusion NNS cord-010119-t1x9gknd 8344 17 , , , cord-010119-t1x9gknd 8344 18 leading lead VBG cord-010119-t1x9gknd 8344 19 to to IN cord-010119-t1x9gknd 8344 20 blood blood NN cord-010119-t1x9gknd 8344 21 units unit NNS cord-010119-t1x9gknd 8344 22 not not RB cord-010119-t1x9gknd 8344 23 being be VBG cord-010119-t1x9gknd 8344 24 checked check VBN cord-010119-t1x9gknd 8344 25 to to TO cord-010119-t1x9gknd 8344 26 ensure ensure VB cord-010119-t1x9gknd 8344 27 they -PRON- PRP cord-010119-t1x9gknd 8344 28 were be VBD cord-010119-t1x9gknd 8344 29 for for IN cord-010119-t1x9gknd 8344 30 the the DT cord-010119-t1x9gknd 8344 31 correct correct JJ cord-010119-t1x9gknd 8344 32 patient patient NN cord-010119-t1x9gknd 8344 33 . . . cord-010119-t1x9gknd 8345 1 Study Study NNP cord-010119-t1x9gknd 8345 2 Design Design NNP cord-010119-t1x9gknd 8345 3 / / SYM cord-010119-t1x9gknd 8345 4 Method method NN cord-010119-t1x9gknd 8345 5 : : : cord-010119-t1x9gknd 8346 1 This this DT cord-010119-t1x9gknd 8346 2 center center NN cord-010119-t1x9gknd 8346 3 worked work VBD cord-010119-t1x9gknd 8346 4 with with IN cord-010119-t1x9gknd 8346 5 the the DT cord-010119-t1x9gknd 8346 6 software software NN cord-010119-t1x9gknd 8346 7 supplier supplier NN cord-010119-t1x9gknd 8346 8 to to TO cord-010119-t1x9gknd 8346 9 develop develop VB cord-010119-t1x9gknd 8346 10 a a DT cord-010119-t1x9gknd 8346 11 solution solution NN cord-010119-t1x9gknd 8346 12 which which WDT cord-010119-t1x9gknd 8346 13 corrects correct VBZ cord-010119-t1x9gknd 8346 14 the the DT cord-010119-t1x9gknd 8346 15 weakness weakness NN cord-010119-t1x9gknd 8346 16 in in IN cord-010119-t1x9gknd 8346 17 the the DT cord-010119-t1x9gknd 8346 18 process process NN cord-010119-t1x9gknd 8346 19 . . . cord-010119-t1x9gknd 8347 1 The the DT cord-010119-t1x9gknd 8347 2 revised revised JJ cord-010119-t1x9gknd 8347 3 process process NN cord-010119-t1x9gknd 8347 4 involves involve VBZ cord-010119-t1x9gknd 8347 5 providing provide VBG cord-010119-t1x9gknd 8347 6 a a DT cord-010119-t1x9gknd 8347 7 universal universal JJ cord-010119-t1x9gknd 8347 8 compatibility compatibility NN cord-010119-t1x9gknd 8347 9 label label NN cord-010119-t1x9gknd 8347 10 for for IN cord-010119-t1x9gknd 8347 11 emergency emergency NN cord-010119-t1x9gknd 8347 12 units unit NNS cord-010119-t1x9gknd 8347 13 so so IN cord-010119-t1x9gknd 8347 14 that that IN cord-010119-t1x9gknd 8347 15 all all DT cord-010119-t1x9gknd 8347 16 units unit NNS cord-010119-t1x9gknd 8347 17 ( ( -LRB- cord-010119-t1x9gknd 8347 18 emergency emergency NN cord-010119-t1x9gknd 8347 19 and and CC cord-010119-t1x9gknd 8347 20 non non JJ cord-010119-t1x9gknd 8347 21 - - JJ cord-010119-t1x9gknd 8347 22 emergency emergency JJ cord-010119-t1x9gknd 8347 23 ) ) -RRB- cord-010119-t1x9gknd 8347 24 require require VBP cord-010119-t1x9gknd 8347 25 a a DT cord-010119-t1x9gknd 8347 26 scan scan NN cord-010119-t1x9gknd 8347 27 of of IN cord-010119-t1x9gknd 8347 28 the the DT cord-010119-t1x9gknd 8347 29 compatibility compatibility NN cord-010119-t1x9gknd 8347 30 label label NN cord-010119-t1x9gknd 8347 31 on on IN cord-010119-t1x9gknd 8347 32 the the DT cord-010119-t1x9gknd 8347 33 blood blood NN cord-010119-t1x9gknd 8347 34 bag bag NN cord-010119-t1x9gknd 8347 35 and and CC cord-010119-t1x9gknd 8347 36 the the DT cord-010119-t1x9gknd 8347 37 patient patient NN cord-010119-t1x9gknd 8347 38 's 's POS cord-010119-t1x9gknd 8347 39 wristband wristband NN cord-010119-t1x9gknd 8347 40 at at IN cord-010119-t1x9gknd 8347 41 the the DT cord-010119-t1x9gknd 8347 42 bedside bedside NN cord-010119-t1x9gknd 8347 43 before before IN cord-010119-t1x9gknd 8347 44 transfusion transfusion NN cord-010119-t1x9gknd 8347 45 . . . cord-010119-t1x9gknd 8348 1 The the DT cord-010119-t1x9gknd 8348 2 use use NN cord-010119-t1x9gknd 8348 3 of of IN cord-010119-t1x9gknd 8348 4 the the DT cord-010119-t1x9gknd 8348 5 emergency emergency NN cord-010119-t1x9gknd 8348 6 process process NN cord-010119-t1x9gknd 8348 7 was be VBD cord-010119-t1x9gknd 8348 8 audited audit VBN cord-010119-t1x9gknd 8348 9 pre pre JJ cord-010119-t1x9gknd 8348 10 and and CC cord-010119-t1x9gknd 8348 11 post post JJ cord-010119-t1x9gknd 8348 12 implementation implementation NN cord-010119-t1x9gknd 8348 13 of of IN cord-010119-t1x9gknd 8348 14 the the DT cord-010119-t1x9gknd 8348 15 new new JJ cord-010119-t1x9gknd 8348 16 process process NN cord-010119-t1x9gknd 8348 17 to to TO cord-010119-t1x9gknd 8348 18 determine determine VB cord-010119-t1x9gknd 8348 19 whether whether IN cord-010119-t1x9gknd 8348 20 it -PRON- PRP cord-010119-t1x9gknd 8348 21 was be VBD cord-010119-t1x9gknd 8348 22 being be VBG cord-010119-t1x9gknd 8348 23 used use VBN cord-010119-t1x9gknd 8348 24 correctly correctly RB cord-010119-t1x9gknd 8348 25 or or CC cord-010119-t1x9gknd 8348 26 not not RB cord-010119-t1x9gknd 8348 27 . . . cord-010119-t1x9gknd 8349 1 Results/ Results/ . cord-010119-t1x9gknd 8350 1 Finding find VBG cord-010119-t1x9gknd 8351 1 : : : cord-010119-t1x9gknd 8351 2 There there EX cord-010119-t1x9gknd 8351 3 were be VBD cord-010119-t1x9gknd 8351 4 593 593 CD cord-010119-t1x9gknd 8351 5 units unit NNS cord-010119-t1x9gknd 8351 6 administered administer VBN cord-010119-t1x9gknd 8351 7 using use VBG cord-010119-t1x9gknd 8351 8 the the DT cord-010119-t1x9gknd 8351 9 emergency emergency NN cord-010119-t1x9gknd 8351 10 transfusion transfusion NN cord-010119-t1x9gknd 8351 11 process process NN cord-010119-t1x9gknd 8351 12 in in IN cord-010119-t1x9gknd 8351 13 the the DT cord-010119-t1x9gknd 8351 14 3 3 CD cord-010119-t1x9gknd 8351 15 months month NNS cord-010119-t1x9gknd 8351 16 before before IN cord-010119-t1x9gknd 8351 17 the the DT cord-010119-t1x9gknd 8351 18 change change NN cord-010119-t1x9gknd 8351 19 was be VBD cord-010119-t1x9gknd 8351 20 implemented implement VBN cord-010119-t1x9gknd 8351 21 . . . cord-010119-t1x9gknd 8352 1 It -PRON- PRP cord-010119-t1x9gknd 8352 2 was be VBD cord-010119-t1x9gknd 8352 3 found find VBN cord-010119-t1x9gknd 8352 4 that that IN cord-010119-t1x9gknd 8352 5 51/593 51/593 CD cord-010119-t1x9gknd 8352 6 ( ( -LRB- cord-010119-t1x9gknd 8352 7 9 9 CD cord-010119-t1x9gknd 8352 8 % % NN cord-010119-t1x9gknd 8352 9 ) ) -RRB- cord-010119-t1x9gknd 8352 10 units unit NNS cord-010119-t1x9gknd 8352 11 were be VBD cord-010119-t1x9gknd 8352 12 non non JJ cord-010119-t1x9gknd 8352 13 - - JJ cord-010119-t1x9gknd 8352 14 emergency emergency JJ cord-010119-t1x9gknd 8352 15 units unit NNS cord-010119-t1x9gknd 8352 16 administered administer VBN cord-010119-t1x9gknd 8352 17 incorrectly incorrectly RB cord-010119-t1x9gknd 8352 18 without without IN cord-010119-t1x9gknd 8352 19 a a DT cord-010119-t1x9gknd 8352 20 bedside bedside NN cord-010119-t1x9gknd 8352 21 compatibility compatibility NN cord-010119-t1x9gknd 8352 22 check check NN cord-010119-t1x9gknd 8352 23 . . . cord-010119-t1x9gknd 8353 1 Following follow VBG cord-010119-t1x9gknd 8353 2 the the DT cord-010119-t1x9gknd 8353 3 implementation implementation NN cord-010119-t1x9gknd 8353 4 of of IN cord-010119-t1x9gknd 8353 5 the the DT cord-010119-t1x9gknd 8353 6 change change NN cord-010119-t1x9gknd 8353 7 there there EX cord-010119-t1x9gknd 8353 8 were be VBD cord-010119-t1x9gknd 8353 9 no no DT cord-010119-t1x9gknd 8353 10 instances instance NNS cord-010119-t1x9gknd 8353 11 of of IN cord-010119-t1x9gknd 8353 12 incorrect incorrect JJ cord-010119-t1x9gknd 8353 13 administration administration NN cord-010119-t1x9gknd 8353 14 of of IN cord-010119-t1x9gknd 8353 15 non non JJ cord-010119-t1x9gknd 8353 16 - - JJ cord-010119-t1x9gknd 8353 17 emergency emergency JJ cord-010119-t1x9gknd 8353 18 units unit NNS cord-010119-t1x9gknd 8353 19 in in IN cord-010119-t1x9gknd 8353 20 the the DT cord-010119-t1x9gknd 8353 21 next next JJ cord-010119-t1x9gknd 8353 22 month month NN cord-010119-t1x9gknd 8353 23 ( ( -LRB- cord-010119-t1x9gknd 8353 24 2530 2530 CD cord-010119-t1x9gknd 8353 25 components component NNS cord-010119-t1x9gknd 8353 26 administered administer VBN cord-010119-t1x9gknd 8353 27 ) ) -RRB- cord-010119-t1x9gknd 8353 28 , , , cord-010119-t1x9gknd 8353 29 109/2530 109/2530 CD cord-010119-t1x9gknd 8353 30 ( ( -LRB- cord-010119-t1x9gknd 8353 31 4 4 CD cord-010119-t1x9gknd 8353 32 % % NN cord-010119-t1x9gknd 8353 33 ) ) -RRB- cord-010119-t1x9gknd 8353 34 were be VBD cord-010119-t1x9gknd 8353 35 emergency emergency NN cord-010119-t1x9gknd 8353 36 units unit NNS cord-010119-t1x9gknd 8353 37 which which WDT cord-010119-t1x9gknd 8353 38 were be VBD cord-010119-t1x9gknd 8353 39 administered administer VBN cord-010119-t1x9gknd 8353 40 correctly correctly RB cord-010119-t1x9gknd 8353 41 . . . cord-010119-t1x9gknd 8354 1 Users user NNS cord-010119-t1x9gknd 8354 2 of of IN cord-010119-t1x9gknd 8354 3 the the DT cord-010119-t1x9gknd 8354 4 system system NN cord-010119-t1x9gknd 8354 5 reported report VBD cord-010119-t1x9gknd 8354 6 the the DT cord-010119-t1x9gknd 8354 7 revised revised JJ cord-010119-t1x9gknd 8354 8 process process NN cord-010119-t1x9gknd 8354 9 was be VBD cord-010119-t1x9gknd 8354 10 quicker quick JJR cord-010119-t1x9gknd 8354 11 , , , cord-010119-t1x9gknd 8354 12 safer safe JJR cord-010119-t1x9gknd 8354 13 and and CC cord-010119-t1x9gknd 8354 14 unified unify VBN cord-010119-t1x9gknd 8354 15 with with IN cord-010119-t1x9gknd 8354 16 other other JJ cord-010119-t1x9gknd 8354 17 functions function NNS cord-010119-t1x9gknd 8354 18 on on IN cord-010119-t1x9gknd 8354 19 the the DT cord-010119-t1x9gknd 8354 20 device device NN cord-010119-t1x9gknd 8354 21 . . . cord-010119-t1x9gknd 8355 1 Conclusion conclusion NN cord-010119-t1x9gknd 8355 2 : : : cord-010119-t1x9gknd 8356 1 The the DT cord-010119-t1x9gknd 8356 2 improved improved JJ cord-010119-t1x9gknd 8356 3 process process NN cord-010119-t1x9gknd 8356 4 for for IN cord-010119-t1x9gknd 8356 5 the the DT cord-010119-t1x9gknd 8356 6 administration administration NN cord-010119-t1x9gknd 8356 7 of of IN cord-010119-t1x9gknd 8356 8 blood blood NN cord-010119-t1x9gknd 8356 9 in in IN cord-010119-t1x9gknd 8356 10 an an DT cord-010119-t1x9gknd 8356 11 emergency emergency NN cord-010119-t1x9gknd 8356 12 now now RB cord-010119-t1x9gknd 8356 13 prevents prevent VBZ cord-010119-t1x9gknd 8356 14 users user NNS cord-010119-t1x9gknd 8356 15 from from IN cord-010119-t1x9gknd 8356 16 following follow VBG cord-010119-t1x9gknd 8356 17 the the DT cord-010119-t1x9gknd 8356 18 incorrect incorrect JJ cord-010119-t1x9gknd 8356 19 procedure procedure NN cord-010119-t1x9gknd 8356 20 for for IN cord-010119-t1x9gknd 8356 21 non non JJ cord-010119-t1x9gknd 8356 22 - - JJ cord-010119-t1x9gknd 8356 23 emergency emergency JJ cord-010119-t1x9gknd 8356 24 transfusions transfusion NNS cord-010119-t1x9gknd 8356 25 and and CC cord-010119-t1x9gknd 8356 26 missing miss VBG cord-010119-t1x9gknd 8356 27 the the DT cord-010119-t1x9gknd 8356 28 essential essential JJ cord-010119-t1x9gknd 8356 29 final final JJ cord-010119-t1x9gknd 8356 30 bedside bedside NN cord-010119-t1x9gknd 8356 31 electronic electronic JJ cord-010119-t1x9gknd 8356 32 check check NN cord-010119-t1x9gknd 8356 33 . . . cord-010119-t1x9gknd 8357 1 This this DT cord-010119-t1x9gknd 8357 2 report report NN cord-010119-t1x9gknd 8357 3 indicates indicate VBZ cord-010119-t1x9gknd 8357 4 the the DT cord-010119-t1x9gknd 8357 5 need need NN cord-010119-t1x9gknd 8357 6 for for IN cord-010119-t1x9gknd 8357 7 continued continued JJ cord-010119-t1x9gknd 8357 8 vigilance vigilance NN cord-010119-t1x9gknd 8357 9 of of IN cord-010119-t1x9gknd 8357 10 the the DT cord-010119-t1x9gknd 8357 11 functionality functionality NN cord-010119-t1x9gknd 8357 12 of of IN cord-010119-t1x9gknd 8357 13 electronic electronic JJ cord-010119-t1x9gknd 8357 14 transfusion transfusion NN cord-010119-t1x9gknd 8357 15 processes process NNS cord-010119-t1x9gknd 8357 16 , , , cord-010119-t1x9gknd 8357 17 and and CC cord-010119-t1x9gknd 8357 18 the the DT cord-010119-t1x9gknd 8357 19 correction correction NN cord-010119-t1x9gknd 8357 20 of of IN cord-010119-t1x9gknd 8357 21 any any DT cord-010119-t1x9gknd 8357 22 weaknesses weakness NNS cord-010119-t1x9gknd 8357 23 compromising compromise VBG cord-010119-t1x9gknd 8357 24 patient patient JJ cord-010119-t1x9gknd 8357 25 safety safety NN cord-010119-t1x9gknd 8357 26 . . . cord-010119-t1x9gknd 8358 1 Background Background NNP cord-010119-t1x9gknd 8358 2 / / SYM cord-010119-t1x9gknd 8358 3 Case Case NNP cord-010119-t1x9gknd 8358 4 Studies Studies NNPS cord-010119-t1x9gknd 8358 5 : : : cord-010119-t1x9gknd 8358 6 Recent recent JJ cord-010119-t1x9gknd 8358 7 recommendations recommendation NNS cord-010119-t1x9gknd 8358 8 indicate indicate VBP cord-010119-t1x9gknd 8358 9 one one CD cord-010119-t1x9gknd 8358 10 red red JJ cord-010119-t1x9gknd 8358 11 blood blood NN cord-010119-t1x9gknd 8358 12 cell cell NN cord-010119-t1x9gknd 8358 13 ( ( -LRB- cord-010119-t1x9gknd 8358 14 RBC RBC NNP cord-010119-t1x9gknd 8358 15 ) ) -RRB- cord-010119-t1x9gknd 8358 16 unit unit NN cord-010119-t1x9gknd 8358 17 should should MD cord-010119-t1x9gknd 8358 18 be be VB cord-010119-t1x9gknd 8358 19 transfused transfuse VBN cord-010119-t1x9gknd 8358 20 at at IN cord-010119-t1x9gknd 8358 21 a a DT cord-010119-t1x9gknd 8358 22 time time NN cord-010119-t1x9gknd 8358 23 with with IN cord-010119-t1x9gknd 8358 24 reassessment reassessment NN cord-010119-t1x9gknd 8358 25 after after IN cord-010119-t1x9gknd 8358 26 each each DT cord-010119-t1x9gknd 8358 27 transfusion transfusion NN cord-010119-t1x9gknd 8358 28 to to TO cord-010119-t1x9gknd 8358 29 determine determine VB cord-010119-t1x9gknd 8358 30 the the DT cord-010119-t1x9gknd 8358 31 need need NN cord-010119-t1x9gknd 8358 32 for for IN cord-010119-t1x9gknd 8358 33 more more JJR cord-010119-t1x9gknd 8358 34 . . . cord-010119-t1x9gknd 8359 1 However however RB cord-010119-t1x9gknd 8359 2 , , , cord-010119-t1x9gknd 8359 3 the the DT cord-010119-t1x9gknd 8359 4 practices practice NNS cord-010119-t1x9gknd 8359 5 of of IN cord-010119-t1x9gknd 8359 6 Canadian canadian JJ cord-010119-t1x9gknd 8359 7 transfusion transfusion NN cord-010119-t1x9gknd 8359 8 medicine medicine NN cord-010119-t1x9gknd 8359 9 ( ( -LRB- cord-010119-t1x9gknd 8359 10 TM TM NNP cord-010119-t1x9gknd 8359 11 ) ) -RRB- cord-010119-t1x9gknd 8359 12 experts expert NNS cord-010119-t1x9gknd 8359 13 and and CC cord-010119-t1x9gknd 8359 14 what what WP cord-010119-t1x9gknd 8359 15 constitutes constitute VBZ cord-010119-t1x9gknd 8359 16 a a DT cord-010119-t1x9gknd 8359 17 reassessment reassessment NN cord-010119-t1x9gknd 8359 18 are be VBP cord-010119-t1x9gknd 8359 19 unknown unknown JJ cord-010119-t1x9gknd 8359 20 . . . cord-010119-t1x9gknd 8360 1 Therefore therefore RB cord-010119-t1x9gknd 8360 2 , , , cord-010119-t1x9gknd 8360 3 we -PRON- PRP cord-010119-t1x9gknd 8360 4 conducted conduct VBD cord-010119-t1x9gknd 8360 5 a a DT cord-010119-t1x9gknd 8360 6 survey survey NN cord-010119-t1x9gknd 8360 7 of of IN cord-010119-t1x9gknd 8360 8 TM TM NNP cord-010119-t1x9gknd 8360 9 experts expert NNS cord-010119-t1x9gknd 8360 10 across across IN cord-010119-t1x9gknd 8360 11 Canada Canada NNP cord-010119-t1x9gknd 8360 12 to to TO cord-010119-t1x9gknd 8360 13 gather gather VB cord-010119-t1x9gknd 8360 14 information information NN cord-010119-t1x9gknd 8360 15 on on IN cord-010119-t1x9gknd 8360 16 their -PRON- PRP$ cord-010119-t1x9gknd 8360 17 practices practice NNS cord-010119-t1x9gknd 8360 18 and and CC cord-010119-t1x9gknd 8360 19 criteria criterion NNS cord-010119-t1x9gknd 8360 20 for for IN cord-010119-t1x9gknd 8360 21 reassessment reassessment NN cord-010119-t1x9gknd 8360 22 . . . cord-010119-t1x9gknd 8361 1 Study Study NNP cord-010119-t1x9gknd 8361 2 Design Design NNP cord-010119-t1x9gknd 8361 3 / / SYM cord-010119-t1x9gknd 8361 4 Method method NN cord-010119-t1x9gknd 8361 5 : : : cord-010119-t1x9gknd 8362 1 TM TM NNP cord-010119-t1x9gknd 8362 2 experts expert NNS cord-010119-t1x9gknd 8362 3 were be VBD cord-010119-t1x9gknd 8362 4 identified identify VBN cord-010119-t1x9gknd 8362 5 and and CC cord-010119-t1x9gknd 8362 6 contact contact NN cord-010119-t1x9gknd 8362 7 information information NN cord-010119-t1x9gknd 8362 8 obtained obtain VBN cord-010119-t1x9gknd 8362 9 from from IN cord-010119-t1x9gknd 8362 10 the the DT cord-010119-t1x9gknd 8362 11 Canadian Canadian NNP cord-010119-t1x9gknd 8362 12 National National NNP cord-010119-t1x9gknd 8362 13 Advisory Advisory NNP cord-010119-t1x9gknd 8362 14 Committee Committee NNP cord-010119-t1x9gknd 8362 15 ( ( -LRB- cord-010119-t1x9gknd 8362 16 NAC NAC NNP cord-010119-t1x9gknd 8362 17 ) ) -RRB- cord-010119-t1x9gknd 8362 18 and and CC cord-010119-t1x9gknd 8362 19 from from IN cord-010119-t1x9gknd 8362 20 contacting contact VBG cord-010119-t1x9gknd 8362 21 least least RBS cord-010119-t1x9gknd 8362 22 one one CD cord-010119-t1x9gknd 8362 23 TM TM NNP cord-010119-t1x9gknd 8362 24 expert expert NN cord-010119-t1x9gknd 8362 25 per per IN cord-010119-t1x9gknd 8362 26 province province NN cord-010119-t1x9gknd 8362 27 . . . cord-010119-t1x9gknd 8363 1 Each each DT cord-010119-t1x9gknd 8363 2 respondent respondent NN cord-010119-t1x9gknd 8363 3 was be VBD cord-010119-t1x9gknd 8363 4 assigned assign VBN cord-010119-t1x9gknd 8363 5 a a DT cord-010119-t1x9gknd 8363 6 unique unique JJ cord-010119-t1x9gknd 8363 7 study study NN cord-010119-t1x9gknd 8363 8 ID ID NNP cord-010119-t1x9gknd 8363 9 after after IN cord-010119-t1x9gknd 8363 10 consenting consent VBG cord-010119-t1x9gknd 8363 11 to to IN cord-010119-t1x9gknd 8363 12 the the DT cord-010119-t1x9gknd 8363 13 survey survey NN cord-010119-t1x9gknd 8363 14 , , , cord-010119-t1x9gknd 8363 15 allowing allow VBG cord-010119-t1x9gknd 8363 16 for for IN cord-010119-t1x9gknd 8363 17 anonymity anonymity NN cord-010119-t1x9gknd 8363 18 on on IN cord-010119-t1x9gknd 8363 19 analysis analysis NN cord-010119-t1x9gknd 8363 20 . . . cord-010119-t1x9gknd 8364 1 The the DT cord-010119-t1x9gknd 8364 2 survey survey NN cord-010119-t1x9gknd 8364 3 contained contain VBD cord-010119-t1x9gknd 8364 4 demographics demographic NNS cord-010119-t1x9gknd 8364 5 , , , cord-010119-t1x9gknd 8364 6 general general JJ cord-010119-t1x9gknd 8364 7 practice practice NN cord-010119-t1x9gknd 8364 8 questions question NNS cord-010119-t1x9gknd 8364 9 , , , cord-010119-t1x9gknd 8364 10 and and CC cord-010119-t1x9gknd 8364 11 questions question NNS cord-010119-t1x9gknd 8364 12 regarding regard VBG cord-010119-t1x9gknd 8364 13 transfusion transfusion NN cord-010119-t1x9gknd 8364 14 in in IN cord-010119-t1x9gknd 8364 15 : : : cord-010119-t1x9gknd 8364 16 1 1 LS cord-010119-t1x9gknd 8364 17 ) ) -RRB- cord-010119-t1x9gknd 8364 18 a a DT cord-010119-t1x9gknd 8364 19 stable stable JJ cord-010119-t1x9gknd 8364 20 anemic anemic JJ cord-010119-t1x9gknd 8364 21 inpatient inpatient NN cord-010119-t1x9gknd 8364 22 , , , cord-010119-t1x9gknd 8364 23 2 2 CD cord-010119-t1x9gknd 8364 24 ) ) -RRB- cord-010119-t1x9gknd 8365 1 a a DT cord-010119-t1x9gknd 8365 2 stable stable JJ cord-010119-t1x9gknd 8365 3 anemic anemic JJ cord-010119-t1x9gknd 8365 4 inpatient inpatient NN cord-010119-t1x9gknd 8365 5 to to TO cord-010119-t1x9gknd 8365 6 be be VB cord-010119-t1x9gknd 8365 7 discharged discharge VBN cord-010119-t1x9gknd 8365 8 , , , cord-010119-t1x9gknd 8365 9 and and CC cord-010119-t1x9gknd 8365 10 3 3 LS cord-010119-t1x9gknd 8365 11 ) ) -RRB- cord-010119-t1x9gknd 8365 12 an an DT cord-010119-t1x9gknd 8365 13 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 8365 14 post post JJ cord-010119-t1x9gknd 8365 15 - - JJ cord-010119-t1x9gknd 8365 16 operative operative JJ cord-010119-t1x9gknd 8365 17 inpatient inpatient NN cord-010119-t1x9gknd 8365 18 . . . cord-010119-t1x9gknd 8366 1 Results/ Results/ . cord-010119-t1x9gknd 8367 1 Finding find VBG cord-010119-t1x9gknd 8368 1 : : : cord-010119-t1x9gknd 8368 2 We -PRON- PRP cord-010119-t1x9gknd 8368 3 identified identify VBD cord-010119-t1x9gknd 8368 4 67 67 CD cord-010119-t1x9gknd 8368 5 Canadian canadian JJ cord-010119-t1x9gknd 8368 6 TM TM NNP cord-010119-t1x9gknd 8368 7 experts expert NNS cord-010119-t1x9gknd 8368 8 : : : cord-010119-t1x9gknd 8368 9 48 48 CD cord-010119-t1x9gknd 8368 10 ( ( -LRB- cord-010119-t1x9gknd 8368 11 71.6 71.6 CD cord-010119-t1x9gknd 8368 12 % % NN cord-010119-t1x9gknd 8368 13 ) ) -RRB- cord-010119-t1x9gknd 8368 14 provided provide VBD cord-010119-t1x9gknd 8368 15 a a DT cord-010119-t1x9gknd 8368 16 response response NN cord-010119-t1x9gknd 8368 17 and and CC cord-010119-t1x9gknd 8368 18 most most RBS cord-010119-t1x9gknd 8368 19 had have VBD cord-010119-t1x9gknd 8368 20 a a DT cord-010119-t1x9gknd 8368 21 primary primary JJ cord-010119-t1x9gknd 8368 22 place place NN cord-010119-t1x9gknd 8368 23 of of IN cord-010119-t1x9gknd 8368 24 practice practice NN cord-010119-t1x9gknd 8368 25 in in IN cord-010119-t1x9gknd 8368 26 a a DT cord-010119-t1x9gknd 8368 27 laboratory laboratory NN cord-010119-t1x9gknd 8368 28 setting setting NN cord-010119-t1x9gknd 8368 29 ( ( -LRB- cord-010119-t1x9gknd 8368 30 38/48 38/48 CD cord-010119-t1x9gknd 8368 31 ; ; : cord-010119-t1x9gknd 8368 32 79.2 79.2 CD cord-010119-t1x9gknd 8368 33 % % NN cord-010119-t1x9gknd 8368 34 ) ) -RRB- cord-010119-t1x9gknd 8368 35 . . . cord-010119-t1x9gknd 8369 1 For for IN cord-010119-t1x9gknd 8369 2 a a DT cord-010119-t1x9gknd 8369 3 stable stable JJ cord-010119-t1x9gknd 8369 4 , , , cord-010119-t1x9gknd 8369 5 non non JJ cord-010119-t1x9gknd 8369 6 - - JJ cord-010119-t1x9gknd 8369 7 bleeding bleeding JJ cord-010119-t1x9gknd 8369 8 , , , cord-010119-t1x9gknd 8369 9 anemic anemic JJ cord-010119-t1x9gknd 8369 10 inpatient inpatient JJ cord-010119-t1x9gknd 8369 11 , , , cord-010119-t1x9gknd 8369 12 87.5 87.5 CD cord-010119-t1x9gknd 8369 13 % % NN cord-010119-t1x9gknd 8369 14 of of IN cord-010119-t1x9gknd 8369 15 respondents respondent NNS cord-010119-t1x9gknd 8369 16 recommended recommend VBD cord-010119-t1x9gknd 8369 17 transfusing transfuse VBG cord-010119-t1x9gknd 8369 18 one one CD cord-010119-t1x9gknd 8369 19 RBC RBC NNP cord-010119-t1x9gknd 8369 20 unit unit NN cord-010119-t1x9gknd 8369 21 , , , cord-010119-t1x9gknd 8369 22 then then RB cord-010119-t1x9gknd 8369 23 reassessing reassess VBG cord-010119-t1x9gknd 8369 24 . . . cord-010119-t1x9gknd 8370 1 Recommendations recommendation NNS cord-010119-t1x9gknd 8370 2 were be VBD cord-010119-t1x9gknd 8370 3 more more RBR cord-010119-t1x9gknd 8370 4 variable variable JJ cord-010119-t1x9gknd 8370 5 in in IN cord-010119-t1x9gknd 8370 6 outpatient outpatient NN cord-010119-t1x9gknd 8370 7 settings setting NNS cord-010119-t1x9gknd 8370 8 , , , cord-010119-t1x9gknd 8370 9 with with IN cord-010119-t1x9gknd 8370 10 31.2 31.2 CD cord-010119-t1x9gknd 8370 11 % % NN cord-010119-t1x9gknd 8370 12 generally generally RB cord-010119-t1x9gknd 8370 13 recommending recommend VBG cord-010119-t1x9gknd 8370 14 transfusing transfuse VBG cord-010119-t1x9gknd 8370 15 two two CD cord-010119-t1x9gknd 8370 16 RBC RBC NNP cord-010119-t1x9gknd 8370 17 units unit NNS cord-010119-t1x9gknd 8370 18 then then RB cord-010119-t1x9gknd 8370 19 reassessing reassess VBG cord-010119-t1x9gknd 8370 20 . . . cord-010119-t1x9gknd 8371 1 Recommendations recommendation NNS cord-010119-t1x9gknd 8371 2 for for IN cord-010119-t1x9gknd 8371 3 reassessment reassessment NN cord-010119-t1x9gknd 8371 4 were be VBD cord-010119-t1x9gknd 8371 5 mainly mainly RB cord-010119-t1x9gknd 8371 6 functional functional JJ cord-010119-t1x9gknd 8371 7 status status NN cord-010119-t1x9gknd 8371 8 / / SYM cord-010119-t1x9gknd 8371 9 symptoms symptom NNS cord-010119-t1x9gknd 8371 10 and and CC cord-010119-t1x9gknd 8371 11 vitals vital NNS cord-010119-t1x9gknd 8371 12 within within IN cord-010119-t1x9gknd 8371 13 a a DT cord-010119-t1x9gknd 8371 14 short short JJ cord-010119-t1x9gknd 8371 15 time time NN cord-010119-t1x9gknd 8371 16 period period NN cord-010119-t1x9gknd 8371 17 ( ( -LRB- cord-010119-t1x9gknd 8371 18 1 1 CD cord-010119-t1x9gknd 8371 19 - - SYM cord-010119-t1x9gknd 8371 20 2 2 CD cord-010119-t1x9gknd 8371 21 hours hour NNS cord-010119-t1x9gknd 8371 22 ) ) -RRB- cord-010119-t1x9gknd 8371 23 , , , cord-010119-t1x9gknd 8371 24 a a DT cord-010119-t1x9gknd 8371 25 repeat repeat NN cord-010119-t1x9gknd 8371 26 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8371 27 > > XX cord-010119-t1x9gknd 8371 28 18 18 CD cord-010119-t1x9gknd 8371 29 hours hour NNS cord-010119-t1x9gknd 8371 30 later later RB cord-010119-t1x9gknd 8371 31 dependent dependent JJ cord-010119-t1x9gknd 8371 32 on on IN cord-010119-t1x9gknd 8371 33 the the DT cord-010119-t1x9gknd 8371 34 clinical clinical JJ cord-010119-t1x9gknd 8371 35 scenario scenario NN cord-010119-t1x9gknd 8371 36 , , , cord-010119-t1x9gknd 8371 37 and and CC cord-010119-t1x9gknd 8371 38 a a DT cord-010119-t1x9gknd 8371 39 search search NN cord-010119-t1x9gknd 8371 40 for for IN cord-010119-t1x9gknd 8371 41 an an DT cord-010119-t1x9gknd 8371 42 underlying underlying JJ cord-010119-t1x9gknd 8371 43 cause cause NN cord-010119-t1x9gknd 8371 44 of of IN cord-010119-t1x9gknd 8371 45 anemia anemia NN cord-010119-t1x9gknd 8371 46 in in IN cord-010119-t1x9gknd 8371 47 outpatient outpatient NN cord-010119-t1x9gknd 8371 48 settings setting NNS cord-010119-t1x9gknd 8371 49 . . . cord-010119-t1x9gknd 8372 1 Lab lab NN cord-010119-t1x9gknd 8372 2 practitioners practitioner NNS cord-010119-t1x9gknd 8372 3 emphasized emphasize VBD cord-010119-t1x9gknd 8372 4 volume volume NN cord-010119-t1x9gknd 8372 5 status status NN cord-010119-t1x9gknd 8372 6 , , , cord-010119-t1x9gknd 8372 7 cardiac cardiac JJ cord-010119-t1x9gknd 8372 8 examination examination NN cord-010119-t1x9gknd 8372 9 , , , cord-010119-t1x9gknd 8372 10 and and CC cord-010119-t1x9gknd 8372 11 transfusion transfusion NN cord-010119-t1x9gknd 8372 12 at at IN cord-010119-t1x9gknd 8372 13 lower low JJR cord-010119-t1x9gknd 8372 14 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8372 15 thresholds threshold NNS cord-010119-t1x9gknd 8372 16 . . . cord-010119-t1x9gknd 8373 1 With with IN cord-010119-t1x9gknd 8373 2 an an DT cord-010119-t1x9gknd 8373 3 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 8373 4 patient patient NN cord-010119-t1x9gknd 8373 5 to to TO cord-010119-t1x9gknd 8373 6 be be VB cord-010119-t1x9gknd 8373 7 discharged discharge VBN cord-010119-t1x9gknd 8373 8 , , , cord-010119-t1x9gknd 8373 9 fewer few JJR cord-010119-t1x9gknd 8373 10 respondents respondent NNS cord-010119-t1x9gknd 8373 11 chose choose VBD cord-010119-t1x9gknd 8373 12 to to TO cord-010119-t1x9gknd 8373 13 transfuse transfuse VB cord-010119-t1x9gknd 8373 14 ( ( -LRB- cord-010119-t1x9gknd 8373 15 38.1 38.1 CD cord-010119-t1x9gknd 8373 16 % % NN cord-010119-t1x9gknd 8373 17 ) ) -RRB- cord-010119-t1x9gknd 8373 18 compared compare VBN cord-010119-t1x9gknd 8373 19 to to IN cord-010119-t1x9gknd 8373 20 an an DT cord-010119-t1x9gknd 8373 21 inpatient inpatient NN cord-010119-t1x9gknd 8373 22 potentially potentially RB cord-010119-t1x9gknd 8373 23 symptomatic symptomatic JJ cord-010119-t1x9gknd 8373 24 due due IN cord-010119-t1x9gknd 8373 25 to to IN cord-010119-t1x9gknd 8373 26 anemia anemia NN cord-010119-t1x9gknd 8373 27 ( ( -LRB- cord-010119-t1x9gknd 8373 28 72.1 72.1 CD cord-010119-t1x9gknd 8373 29 % % NN cord-010119-t1x9gknd 8373 30 ) ) -RRB- cord-010119-t1x9gknd 8373 31 . . . cord-010119-t1x9gknd 8374 1 None none NN cord-010119-t1x9gknd 8374 2 of of IN cord-010119-t1x9gknd 8374 3 the the DT cord-010119-t1x9gknd 8374 4 respondents respondent NNS cord-010119-t1x9gknd 8374 5 suggested suggest VBD cord-010119-t1x9gknd 8374 6 transfusion transfusion NN cord-010119-t1x9gknd 8374 7 in in IN cord-010119-t1x9gknd 8374 8 an an DT cord-010119-t1x9gknd 8374 9 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 8374 10 post post JJ cord-010119-t1x9gknd 8374 11 - - JJ cord-010119-t1x9gknd 8374 12 operative operative JJ cord-010119-t1x9gknd 8374 13 patient patient NN cord-010119-t1x9gknd 8374 14 who who WP cord-010119-t1x9gknd 8374 15 had have VBD cord-010119-t1x9gknd 8374 16 a a DT cord-010119-t1x9gknd 8374 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8374 18 trending trend VBG cord-010119-t1x9gknd 8374 19 down down RB cord-010119-t1x9gknd 8374 20 . . . cord-010119-t1x9gknd 8375 1 Conclusion conclusion NN cord-010119-t1x9gknd 8375 2 : : : cord-010119-t1x9gknd 8376 1 TM TM NNP cord-010119-t1x9gknd 8376 2 experts expert NNS cord-010119-t1x9gknd 8376 3 generally generally RB cord-010119-t1x9gknd 8376 4 recommend recommend VBP cord-010119-t1x9gknd 8376 5 transfusing transfuse VBG cord-010119-t1x9gknd 8376 6 one one CD cord-010119-t1x9gknd 8376 7 unit unit NN cord-010119-t1x9gknd 8376 8 at at IN cord-010119-t1x9gknd 8376 9 a a DT cord-010119-t1x9gknd 8376 10 time time NN cord-010119-t1x9gknd 8376 11 in in IN cord-010119-t1x9gknd 8376 12 stable stable JJ cord-010119-t1x9gknd 8376 13 inpatients inpatient NNS cord-010119-t1x9gknd 8376 14 . . . cord-010119-t1x9gknd 8377 1 Assessment assessment NN cord-010119-t1x9gknd 8377 2 for for IN cord-010119-t1x9gknd 8377 3 transfusion transfusion NN cord-010119-t1x9gknd 8377 4 should should MD cord-010119-t1x9gknd 8377 5 focus focus VB cord-010119-t1x9gknd 8377 6 on on IN cord-010119-t1x9gknd 8377 7 patient patient JJ cord-010119-t1x9gknd 8377 8 symptoms symptom NNS cord-010119-t1x9gknd 8377 9 , , , cord-010119-t1x9gknd 8377 10 pertinent pertinent JJ cord-010119-t1x9gknd 8377 11 physical physical JJ cord-010119-t1x9gknd 8377 12 exam exam NN cord-010119-t1x9gknd 8377 13 , , , cord-010119-t1x9gknd 8377 14 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8377 15 levels level NNS cord-010119-t1x9gknd 8377 16 , , , cord-010119-t1x9gknd 8377 17 and and CC cord-010119-t1x9gknd 8377 18 an an DT cord-010119-t1x9gknd 8377 19 underlying underlying JJ cord-010119-t1x9gknd 8377 20 cause cause NN cord-010119-t1x9gknd 8377 21 . . . cord-010119-t1x9gknd 8378 1 " " `` cord-010119-t1x9gknd 8378 2 Top top JJ cord-010119-t1x9gknd 8378 3 - - HYPH cord-010119-t1x9gknd 8378 4 up up RP cord-010119-t1x9gknd 8378 5 " " '' cord-010119-t1x9gknd 8378 6 transfusions transfusion NNS cord-010119-t1x9gknd 8378 7 were be VBD cord-010119-t1x9gknd 8378 8 not not RB cord-010119-t1x9gknd 8378 9 recommended recommend VBN cord-010119-t1x9gknd 8378 10 . . . cord-010119-t1x9gknd 8379 1 These these DT cord-010119-t1x9gknd 8379 2 recommendations recommendation NNS cord-010119-t1x9gknd 8379 3 may may MD cord-010119-t1x9gknd 8379 4 help help VB cord-010119-t1x9gknd 8379 5 guide guide VB cord-010119-t1x9gknd 8379 6 clinicians clinician NNS cord-010119-t1x9gknd 8379 7 , , , cord-010119-t1x9gknd 8379 8 but but CC cord-010119-t1x9gknd 8379 9 further further JJ cord-010119-t1x9gknd 8379 10 research research NN cord-010119-t1x9gknd 8379 11 is be VBZ cord-010119-t1x9gknd 8379 12 needed need VBN cord-010119-t1x9gknd 8379 13 to to TO cord-010119-t1x9gknd 8379 14 generate generate VB cord-010119-t1x9gknd 8379 15 higher high JJR cord-010119-t1x9gknd 8379 16 quality quality NN cord-010119-t1x9gknd 8379 17 evidence evidence NN cord-010119-t1x9gknd 8379 18 around around IN cord-010119-t1x9gknd 8379 19 the the DT cord-010119-t1x9gknd 8379 20 clinical clinical JJ cord-010119-t1x9gknd 8379 21 benefits benefit NNS cord-010119-t1x9gknd 8379 22 and and CC cord-010119-t1x9gknd 8379 23 cost cost NN cord-010119-t1x9gknd 8379 24 effectiveness effectiveness NN cord-010119-t1x9gknd 8379 25 of of IN cord-010119-t1x9gknd 8379 26 these these DT cord-010119-t1x9gknd 8379 27 practices practice NNS cord-010119-t1x9gknd 8379 28 . . . cord-010119-t1x9gknd 8380 1 Background Background NNP cord-010119-t1x9gknd 8380 2 / / SYM cord-010119-t1x9gknd 8380 3 Case Case NNP cord-010119-t1x9gknd 8380 4 Studies Studies NNPS cord-010119-t1x9gknd 8380 5 : : : cord-010119-t1x9gknd 8380 6 Current current JJ cord-010119-t1x9gknd 8380 7 evaluation evaluation NN cord-010119-t1x9gknd 8380 8 of of IN cord-010119-t1x9gknd 8380 9 red red JJ cord-010119-t1x9gknd 8380 10 blood blood NN cord-010119-t1x9gknd 8380 11 cell cell NN cord-010119-t1x9gknd 8380 12 ( ( -LRB- cord-010119-t1x9gknd 8380 13 RBC RBC NNP cord-010119-t1x9gknd 8380 14 ) ) -RRB- cord-010119-t1x9gknd 8381 1 post post JJ cord-010119-t1x9gknd 8381 2 transfusion transfusion NN cord-010119-t1x9gknd 8381 3 recovery recovery NN cord-010119-t1x9gknd 8381 4 is be VBZ cord-010119-t1x9gknd 8381 5 based base VBN cord-010119-t1x9gknd 8381 6 on on IN cord-010119-t1x9gknd 8381 7 ex ex FW cord-010119-t1x9gknd 8381 8 vivo vivo NN cord-010119-t1x9gknd 8381 9 labeling labeling NN cord-010119-t1x9gknd 8381 10 of of IN cord-010119-t1x9gknd 8381 11 stored store VBN cord-010119-t1x9gknd 8381 12 RBCs rbc NNS cord-010119-t1x9gknd 8381 13 with with IN cord-010119-t1x9gknd 8381 14 radioactive radioactive JJ cord-010119-t1x9gknd 8381 15 chromium-51 chromium-51 NNP cord-010119-t1x9gknd 8381 16 ( ( -LRB- cord-010119-t1x9gknd 8381 17 51 51 CD cord-010119-t1x9gknd 8381 18 Cr Cr NNS cord-010119-t1x9gknd 8381 19 ) ) -RRB- cord-010119-t1x9gknd 8381 20 . . . cord-010119-t1x9gknd 8382 1 This this DT cord-010119-t1x9gknd 8382 2 method method NN cord-010119-t1x9gknd 8382 3 has have VBZ cord-010119-t1x9gknd 8382 4 several several JJ cord-010119-t1x9gknd 8382 5 limitations limitation NNS cord-010119-t1x9gknd 8382 6 including include VBG cord-010119-t1x9gknd 8382 7 the the DT cord-010119-t1x9gknd 8382 8 risks risk NNS cord-010119-t1x9gknd 8382 9 associated associate VBN cord-010119-t1x9gknd 8382 10 with with IN cord-010119-t1x9gknd 8382 11 radioactivity radioactivity NN cord-010119-t1x9gknd 8382 12 , , , cord-010119-t1x9gknd 8382 13 and and CC cord-010119-t1x9gknd 8382 14 the the DT cord-010119-t1x9gknd 8382 15 inability inability NN cord-010119-t1x9gknd 8382 16 to to TO cord-010119-t1x9gknd 8382 17 evaluate evaluate VB cord-010119-t1x9gknd 8382 18 multiple multiple JJ cord-010119-t1x9gknd 8382 19 RBC RBC NNP cord-010119-t1x9gknd 8382 20 populations population NNS cord-010119-t1x9gknd 8382 21 in in IN cord-010119-t1x9gknd 8382 22 the the DT cord-010119-t1x9gknd 8382 23 recipient recipient NN cord-010119-t1x9gknd 8382 24 . . . cord-010119-t1x9gknd 8383 1 RBC RBC NNP cord-010119-t1x9gknd 8383 2 labeling labeling NN cord-010119-t1x9gknd 8383 3 with with IN cord-010119-t1x9gknd 8383 4 s s NNP cord-010119-t1x9gknd 8383 5 - - HYPH cord-010119-t1x9gknd 8383 6 NHS NHS NNP cord-010119-t1x9gknd 8383 7 - - HYPH cord-010119-t1x9gknd 8383 8 biotin biotin NNP cord-010119-t1x9gknd 8383 9 ( ( -LRB- cord-010119-t1x9gknd 8383 10 Bio Bio NNP cord-010119-t1x9gknd 8383 11 - - HYPH cord-010119-t1x9gknd 8383 12 RBCs rbc NNS cord-010119-t1x9gknd 8383 13 ) ) -RRB- cord-010119-t1x9gknd 8383 14 overcomes overcome VBZ cord-010119-t1x9gknd 8383 15 many many JJ cord-010119-t1x9gknd 8383 16 of of IN cord-010119-t1x9gknd 8383 17 these these DT cord-010119-t1x9gknd 8383 18 limitations limitation NNS cord-010119-t1x9gknd 8383 19 and and CC cord-010119-t1x9gknd 8383 20 offers offer VBZ cord-010119-t1x9gknd 8383 21 safe safe JJ cord-010119-t1x9gknd 8383 22 and and CC cord-010119-t1x9gknd 8383 23 longitudinal longitudinal JJ cord-010119-t1x9gknd 8383 24 tracking tracking NN cord-010119-t1x9gknd 8383 25 of of IN cord-010119-t1x9gknd 8383 26 multiple multiple JJ cord-010119-t1x9gknd 8383 27 transfused transfuse VBN cord-010119-t1x9gknd 8383 28 RBCs rbc NNS cord-010119-t1x9gknd 8383 29 in in IN cord-010119-t1x9gknd 8383 30 vivo vivo NN cord-010119-t1x9gknd 8383 31 . . . cord-010119-t1x9gknd 8384 1 The the DT cord-010119-t1x9gknd 8384 2 purpose purpose NN cord-010119-t1x9gknd 8384 3 of of IN cord-010119-t1x9gknd 8384 4 this this DT cord-010119-t1x9gknd 8384 5 study study NN cord-010119-t1x9gknd 8384 6 was be VBD cord-010119-t1x9gknd 8384 7 to to TO cord-010119-t1x9gknd 8384 8 scale scale VB cord-010119-t1x9gknd 8384 9 up up RP cord-010119-t1x9gknd 8384 10 and and CC cord-010119-t1x9gknd 8384 11 optimize optimize VB cord-010119-t1x9gknd 8384 12 the the DT cord-010119-t1x9gknd 8384 13 biotinylation biotinylation NN cord-010119-t1x9gknd 8384 14 procedures procedure NNS cord-010119-t1x9gknd 8384 15 to to IN cord-010119-t1x9gknd 8384 16 the the DT cord-010119-t1x9gknd 8384 17 current current JJ cord-010119-t1x9gknd 8384 18 Good Good NNP cord-010119-t1x9gknd 8384 19 Manufacturing Manufacturing NNP cord-010119-t1x9gknd 8384 20 Practice Practice NNP cord-010119-t1x9gknd 8384 21 ( ( -LRB- cord-010119-t1x9gknd 8384 22 GMP GMP NNP cord-010119-t1x9gknd 8384 23 ) ) -RRB- cord-010119-t1x9gknd 8384 24 environment environment NN cord-010119-t1x9gknd 8384 25 . . . cord-010119-t1x9gknd 8385 1 Study Study NNP cord-010119-t1x9gknd 8385 2 Design Design NNP cord-010119-t1x9gknd 8385 3 / / SYM cord-010119-t1x9gknd 8385 4 Method method NN cord-010119-t1x9gknd 8385 5 : : : cord-010119-t1x9gknd 8385 6 Packed pack VBN cord-010119-t1x9gknd 8385 7 RBC RBC NNP cord-010119-t1x9gknd 8385 8 units unit NNS cord-010119-t1x9gknd 8385 9 ( ( -LRB- cord-010119-t1x9gknd 8385 10 n514 n514 NNP cord-010119-t1x9gknd 8385 11 ) ) -RRB- cord-010119-t1x9gknd 8385 12 were be VBD cord-010119-t1x9gknd 8385 13 divided divide VBN cord-010119-t1x9gknd 8385 14 into into IN cord-010119-t1x9gknd 8385 15 two two CD cord-010119-t1x9gknd 8385 16 150mL 150ml NN cord-010119-t1x9gknd 8385 17 aliquots aliquot NNS cord-010119-t1x9gknd 8385 18 , , , cord-010119-t1x9gknd 8385 19 which which WDT cord-010119-t1x9gknd 8385 20 were be VBD cord-010119-t1x9gknd 8385 21 labeled label VBN cord-010119-t1x9gknd 8385 22 with with IN cord-010119-t1x9gknd 8385 23 selected select VBN cord-010119-t1x9gknd 8385 24 concentrations concentration NNS cord-010119-t1x9gknd 8385 25 of of IN cord-010119-t1x9gknd 8385 26 s s NNPS cord-010119-t1x9gknd 8385 27 - - HYPH cord-010119-t1x9gknd 8385 28 NHSbiotin NHSbiotin NNP cord-010119-t1x9gknd 8386 1 ( ( -LRB- cord-010119-t1x9gknd 8386 2 3 3 CD cord-010119-t1x9gknd 8386 3 and and CC cord-010119-t1x9gknd 8386 4 30 30 CD cord-010119-t1x9gknd 8386 5 lg lg NN cord-010119-t1x9gknd 8386 6 / / SYM cord-010119-t1x9gknd 8386 7 mL mL NNP cord-010119-t1x9gknd 8386 8 ) ) -RRB- cord-010119-t1x9gknd 8386 9 in in IN cord-010119-t1x9gknd 8386 10 a a DT cord-010119-t1x9gknd 8386 11 CGMP CGMP NNP cord-010119-t1x9gknd 8386 12 closed close VBN cord-010119-t1x9gknd 8386 13 system system NN cord-010119-t1x9gknd 8386 14 ( ( -LRB- cord-010119-t1x9gknd 8386 15 average average JJ cord-010119-t1x9gknd 8386 16 Bio Bio NNP cord-010119-t1x9gknd 8386 17 - - HYPH cord-010119-t1x9gknd 8386 18 RBCs rbc NNS cord-010119-t1x9gknd 8386 19 hematocrit hematocrit NN cord-010119-t1x9gknd 8386 20 of of IN cord-010119-t1x9gknd 8386 21 38.4 38.4 CD cord-010119-t1x9gknd 8386 22 6 6 CD cord-010119-t1x9gknd 8386 23 1.6 1.6 CD cord-010119-t1x9gknd 8386 24 % % NN cord-010119-t1x9gknd 8386 25 ) ) -RRB- cord-010119-t1x9gknd 8386 26 . . . cord-010119-t1x9gknd 8387 1 Optimization optimization NN cord-010119-t1x9gknd 8387 2 of of IN cord-010119-t1x9gknd 8387 3 labeling label VBG cord-010119-t1x9gknd 8387 4 efficacy efficacy NN cord-010119-t1x9gknd 8387 5 was be VBD cord-010119-t1x9gknd 8387 6 determined determine VBN cord-010119-t1x9gknd 8387 7 by by IN cord-010119-t1x9gknd 8387 8 flow flow NN cord-010119-t1x9gknd 8387 9 cytometric cytometric NNP cord-010119-t1x9gknd 8387 10 analysis analysis NN cord-010119-t1x9gknd 8387 11 of of IN cord-010119-t1x9gknd 8387 12 Bio Bio NNP cord-010119-t1x9gknd 8387 13 - - HYPH cord-010119-t1x9gknd 8387 14 RBCs rbc NNS cord-010119-t1x9gknd 8387 15 using use VBG cord-010119-t1x9gknd 8387 16 fluorochrome fluorochrome RB cord-010119-t1x9gknd 8387 17 - - HYPH cord-010119-t1x9gknd 8387 18 conjugated conjugate VBN cord-010119-t1x9gknd 8387 19 streptavidin streptavidin NNS cord-010119-t1x9gknd 8387 20 ( ( -LRB- cord-010119-t1x9gknd 8387 21 SA SA NNP cord-010119-t1x9gknd 8387 22 ) ) -RRB- cord-010119-t1x9gknd 8387 23 . . . cord-010119-t1x9gknd 8388 1 Approximately approximately RB cord-010119-t1x9gknd 8388 2 2 2 CD cord-010119-t1x9gknd 8388 3 million million CD cord-010119-t1x9gknd 8388 4 RBCs rbc NNS cord-010119-t1x9gknd 8388 5 were be VBD cord-010119-t1x9gknd 8388 6 measured measure VBN cord-010119-t1x9gknd 8388 7 in in IN cord-010119-t1x9gknd 8388 8 triplicate triplicate NN cord-010119-t1x9gknd 8388 9 . . . cord-010119-t1x9gknd 8389 1 Quantum Quantum NNP cord-010119-t1x9gknd 8389 2 Simply simply RB cord-010119-t1x9gknd 8389 3 Cellular Cellular NNP cord-010119-t1x9gknd 8389 4 Beads bead NNS cord-010119-t1x9gknd 8389 5 were be VBD cord-010119-t1x9gknd 8389 6 used use VBN cord-010119-t1x9gknd 8389 7 to to TO cord-010119-t1x9gknd 8389 8 quantify quantify VB cord-010119-t1x9gknd 8389 9 fluorochrome fluorochrome NNP cord-010119-t1x9gknd 8389 10 ( ( -LRB- cord-010119-t1x9gknd 8389 11 molecules molecule NNS cord-010119-t1x9gknd 8389 12 of of IN cord-010119-t1x9gknd 8389 13 equivalent equivalent JJ cord-010119-t1x9gknd 8389 14 soluble soluble JJ cord-010119-t1x9gknd 8389 15 fluorescence fluorescence NN cord-010119-t1x9gknd 8389 16 , , , cord-010119-t1x9gknd 8389 17 MESF MESF NNP cord-010119-t1x9gknd 8389 18 ) ) -RRB- cord-010119-t1x9gknd 8389 19 and and CC cord-010119-t1x9gknd 8389 20 infer infer VB cord-010119-t1x9gknd 8389 21 number number NN cord-010119-t1x9gknd 8389 22 of of IN cord-010119-t1x9gknd 8389 23 biotin biotin NN cord-010119-t1x9gknd 8389 24 molecules molecule NNS cord-010119-t1x9gknd 8389 25 per per IN cord-010119-t1x9gknd 8389 26 RBC RBC NNP cord-010119-t1x9gknd 8389 27 . . . cord-010119-t1x9gknd 8390 1 The the DT cord-010119-t1x9gknd 8390 2 lower low JJR cord-010119-t1x9gknd 8390 3 limit limit NN cord-010119-t1x9gknd 8390 4 of of IN cord-010119-t1x9gknd 8390 5 detection detection NN cord-010119-t1x9gknd 8390 6 was be VBD cord-010119-t1x9gknd 8390 7 determined determine VBN cord-010119-t1x9gknd 8390 8 for for IN cord-010119-t1x9gknd 8390 9 RBC RBC NNP cord-010119-t1x9gknd 8390 10 labeled label VBN cord-010119-t1x9gknd 8390 11 with with IN cord-010119-t1x9gknd 8390 12 varying vary VBG cord-010119-t1x9gknd 8390 13 amounts amount NNS cord-010119-t1x9gknd 8390 14 of of IN cord-010119-t1x9gknd 8390 15 biotin biotin NN cord-010119-t1x9gknd 8390 16 . . . cord-010119-t1x9gknd 8391 1 Product product NN cord-010119-t1x9gknd 8391 2 quality quality NN cord-010119-t1x9gknd 8391 3 and and CC cord-010119-t1x9gknd 8391 4 safety safety NN cord-010119-t1x9gknd 8391 5 were be VBD cord-010119-t1x9gknd 8391 6 evaluated evaluate VBN cord-010119-t1x9gknd 8391 7 by by IN cord-010119-t1x9gknd 8391 8 endotoxin endotoxin NN cord-010119-t1x9gknd 8391 9 and and CC cord-010119-t1x9gknd 8391 10 sterility sterility NN cord-010119-t1x9gknd 8391 11 testing testing NN cord-010119-t1x9gknd 8391 12 , , , cord-010119-t1x9gknd 8391 13 and and CC cord-010119-t1x9gknd 8391 14 by by IN cord-010119-t1x9gknd 8391 15 determining determine VBG cord-010119-t1x9gknd 8391 16 the the DT cord-010119-t1x9gknd 8391 17 levels level NNS cord-010119-t1x9gknd 8391 18 of of IN cord-010119-t1x9gknd 8391 19 spontaneous spontaneous JJ cord-010119-t1x9gknd 8391 20 hemolysis hemolysis NN cord-010119-t1x9gknd 8391 21 before before IN cord-010119-t1x9gknd 8391 22 and and CC cord-010119-t1x9gknd 8391 23 after after IN cord-010119-t1x9gknd 8391 24 RBC RBC NNP cord-010119-t1x9gknd 8391 25 biotin biotin NN cord-010119-t1x9gknd 8391 26 labeling labeling NN cord-010119-t1x9gknd 8391 27 . . . cord-010119-t1x9gknd 8392 1 Results/ Results/ . cord-010119-t1x9gknd 8393 1 Finding finding NN cord-010119-t1x9gknd 8393 2 : : : cord-010119-t1x9gknd 8394 1 Investigation investigation NN cord-010119-t1x9gknd 8394 2 of of IN cord-010119-t1x9gknd 8394 3 different different JJ cord-010119-t1x9gknd 8394 4 fluorochromes fluorochrome NNS cord-010119-t1x9gknd 8394 5 , , , cord-010119-t1x9gknd 8394 6 laser laser NN cord-010119-t1x9gknd 8394 7 excitation excitation NN cord-010119-t1x9gknd 8394 8 wavelengths wavelength NNS cord-010119-t1x9gknd 8394 9 and and CC cord-010119-t1x9gknd 8394 10 laser laser NN cord-010119-t1x9gknd 8394 11 power power NN cord-010119-t1x9gknd 8394 12 to to TO cord-010119-t1x9gknd 8394 13 maximize maximize VB cord-010119-t1x9gknd 8394 14 the the DT cord-010119-t1x9gknd 8394 15 signal signal NN cord-010119-t1x9gknd 8394 16 to to IN cord-010119-t1x9gknd 8394 17 noise noise NN cord-010119-t1x9gknd 8394 18 ratio ratio NN cord-010119-t1x9gknd 8394 19 of of IN cord-010119-t1x9gknd 8394 20 labeled label VBN cord-010119-t1x9gknd 8394 21 and and CC cord-010119-t1x9gknd 8394 22 unlabeled unlabeled JJ cord-010119-t1x9gknd 8394 23 RBCs rbc NNS cord-010119-t1x9gknd 8394 24 revealed reveal VBD cord-010119-t1x9gknd 8394 25 that that IN cord-010119-t1x9gknd 8394 26 561 561 CD cord-010119-t1x9gknd 8394 27 nm nm NN cord-010119-t1x9gknd 8394 28 excitation excitation NN cord-010119-t1x9gknd 8394 29 of of IN cord-010119-t1x9gknd 8394 30 phycoerythrin phycoerythrin FW cord-010119-t1x9gknd 8394 31 ( ( -LRB- cord-010119-t1x9gknd 8394 32 PE)-SA pe)-sa NN cord-010119-t1x9gknd 8394 33 and and CC cord-010119-t1x9gknd 8394 34 high high JJ cord-010119-t1x9gknd 8394 35 laser laser NN cord-010119-t1x9gknd 8394 36 power power NN cord-010119-t1x9gknd 8394 37 ( ( -LRB- cord-010119-t1x9gknd 8394 38 150mW 150mw NN cord-010119-t1x9gknd 8394 39 ) ) -RRB- cord-010119-t1x9gknd 8394 40 provided provide VBD cord-010119-t1x9gknd 8394 41 the the DT cord-010119-t1x9gknd 8394 42 best good JJS cord-010119-t1x9gknd 8394 43 separation separation NN cord-010119-t1x9gknd 8394 44 between between IN cord-010119-t1x9gknd 8394 45 the the DT cord-010119-t1x9gknd 8394 46 two two CD cord-010119-t1x9gknd 8394 47 Bio Bio NNP cord-010119-t1x9gknd 8394 48 - - HYPH cord-010119-t1x9gknd 8394 49 RBC RBC NNP cord-010119-t1x9gknd 8394 50 populations population NNS cord-010119-t1x9gknd 8394 51 , , , cord-010119-t1x9gknd 8394 52 and and CC cord-010119-t1x9gknd 8394 53 between between IN cord-010119-t1x9gknd 8394 54 labeled labeled JJ cord-010119-t1x9gknd 8394 55 and and CC cord-010119-t1x9gknd 8394 56 unlabeled unlabeled JJ cord-010119-t1x9gknd 8394 57 RBCs rbc NNS cord-010119-t1x9gknd 8394 58 . . . cord-010119-t1x9gknd 8395 1 Labeling label VBG cord-010119-t1x9gknd 8395 2 with with IN cord-010119-t1x9gknd 8395 3 3lg 3lg NN cord-010119-t1x9gknd 8395 4 / / SYM cord-010119-t1x9gknd 8395 5 mL ml NN cord-010119-t1x9gknd 8395 6 of of IN cord-010119-t1x9gknd 8395 7 biotin biotin NN cord-010119-t1x9gknd 8395 8 resulted result VBD cord-010119-t1x9gknd 8395 9 in in IN cord-010119-t1x9gknd 8395 10 $ $ $ cord-010119-t1x9gknd 8395 11 50,000 50,000 CD cord-010119-t1x9gknd 8395 12 MESF MESF NNP cord-010119-t1x9gknd 8395 13 / / SYM cord-010119-t1x9gknd 8395 14 RBC RBC NNP cord-010119-t1x9gknd 8395 15 , , , cord-010119-t1x9gknd 8395 16 and and CC cord-010119-t1x9gknd 8395 17 were be VBD cord-010119-t1x9gknd 8395 18 detectable detectable JJ cord-010119-t1x9gknd 8395 19 among among IN cord-010119-t1x9gknd 8395 20 unlabeled unlabeled JJ cord-010119-t1x9gknd 8395 21 RBC RBC NNP cord-010119-t1x9gknd 8395 22 at at IN cord-010119-t1x9gknd 8395 23 a a DT cord-010119-t1x9gknd 8395 24 lower low JJR cord-010119-t1x9gknd 8395 25 limit limit NN cord-010119-t1x9gknd 8395 26 of of IN cord-010119-t1x9gknd 8395 27 detection detection NN cord-010119-t1x9gknd 8395 28 ( ( -LRB- cord-010119-t1x9gknd 8395 29 LLD LLD NNP cord-010119-t1x9gknd 8395 30 , , , cord-010119-t1x9gknd 8395 31 95 95 CD cord-010119-t1x9gknd 8395 32 % % NN cord-010119-t1x9gknd 8395 33 CI CI NNP cord-010119-t1x9gknd 8395 34 ) ) -RRB- cord-010119-t1x9gknd 8395 35 of of IN cord-010119-t1x9gknd 8395 36 1 1 CD cord-010119-t1x9gknd 8395 37 in in IN cord-010119-t1x9gknd 8395 38 380,000 380,000 CD cord-010119-t1x9gknd 8395 39 ( ( -LRB- cord-010119-t1x9gknd 8395 40 0.0003 0.0003 CD cord-010119-t1x9gknd 8395 41 % % NN cord-010119-t1x9gknd 8395 42 ) ) -RRB- cord-010119-t1x9gknd 8395 43 . . . cord-010119-t1x9gknd 8396 1 The the DT cord-010119-t1x9gknd 8396 2 LLD95 LLD95 NNP cord-010119-t1x9gknd 8396 3 for for IN cord-010119-t1x9gknd 8396 4 RBC RBC NNP cord-010119-t1x9gknd 8396 5 labeled label VBN cord-010119-t1x9gknd 8396 6 with with IN cord-010119-t1x9gknd 8396 7 biotin biotin NN cord-010119-t1x9gknd 8396 8 at at IN cord-010119-t1x9gknd 8396 9 30lg/ 30lg/ CD cord-010119-t1x9gknd 8396 10 mL ml NN cord-010119-t1x9gknd 8396 11 was be VBD cord-010119-t1x9gknd 8396 12 $ $ $ cord-010119-t1x9gknd 8396 13 1 1 CD cord-010119-t1x9gknd 8396 14 in in IN cord-010119-t1x9gknd 8396 15 1 1 CD cord-010119-t1x9gknd 8396 16 million million CD cord-010119-t1x9gknd 8396 17 ( ( -LRB- cord-010119-t1x9gknd 8396 18 0.0001 0.0001 CD cord-010119-t1x9gknd 8396 19 % % NN cord-010119-t1x9gknd 8396 20 ) ) -RRB- cord-010119-t1x9gknd 8396 21 . . . cord-010119-t1x9gknd 8397 1 Biotinylation Biotinylation NNP cord-010119-t1x9gknd 8397 2 was be VBD cord-010119-t1x9gknd 8397 3 not not RB cord-010119-t1x9gknd 8397 4 associated associate VBN cord-010119-t1x9gknd 8397 5 with with IN cord-010119-t1x9gknd 8397 6 increased increase VBN cord-010119-t1x9gknd 8397 7 levels level NNS cord-010119-t1x9gknd 8397 8 of of IN cord-010119-t1x9gknd 8397 9 hemolysis hemolysis NN cord-010119-t1x9gknd 8397 10 ( ( -LRB- cord-010119-t1x9gknd 8397 11 0.40 0.40 CD cord-010119-t1x9gknd 8397 12 6 6 CD cord-010119-t1x9gknd 8397 13 0.22 0.22 CD cord-010119-t1x9gknd 8397 14 % % NN cord-010119-t1x9gknd 8397 15 before before IN cord-010119-t1x9gknd 8397 16 labeling label VBG cord-010119-t1x9gknd 8397 17 versus versus IN cord-010119-t1x9gknd 8397 18 0.34 0.34 CD cord-010119-t1x9gknd 8397 19 6 6 CD cord-010119-t1x9gknd 8397 20 0.12 0.12 CD cord-010119-t1x9gknd 8397 21 % % NN cord-010119-t1x9gknd 8397 22 after after IN cord-010119-t1x9gknd 8397 23 labeling labeling NN cord-010119-t1x9gknd 8397 24 ; ; : cord-010119-t1x9gknd 8397 25 p50.09 p50.09 JJ cord-010119-t1x9gknd 8397 26 ) ) -RRB- cord-010119-t1x9gknd 8397 27 or or CC cord-010119-t1x9gknd 8397 28 bacterial bacterial JJ cord-010119-t1x9gknd 8397 29 contamination contamination NN cord-010119-t1x9gknd 8397 30 . . . cord-010119-t1x9gknd 8398 1 Conclusion conclusion NN cord-010119-t1x9gknd 8398 2 : : : cord-010119-t1x9gknd 8399 1 The the DT cord-010119-t1x9gknd 8399 2 resulting result VBG cord-010119-t1x9gknd 8399 3 manufacturing manufacturing NN cord-010119-t1x9gknd 8399 4 process process NN cord-010119-t1x9gknd 8399 5 produces produce VBZ cord-010119-t1x9gknd 8399 6 large large JJ cord-010119-t1x9gknd 8399 7 volumes volume NNS cord-010119-t1x9gknd 8399 8 ( ( -LRB- cord-010119-t1x9gknd 8399 9 150mL 150ml NN cord-010119-t1x9gknd 8399 10 / / SYM cord-010119-t1x9gknd 8399 11 transfusion transfusion NN cord-010119-t1x9gknd 8399 12 ) ) -RRB- cord-010119-t1x9gknd 8399 13 of of IN cord-010119-t1x9gknd 8399 14 Bio Bio NNP cord-010119-t1x9gknd 8399 15 - - HYPH cord-010119-t1x9gknd 8399 16 RBCs rbc NNS cord-010119-t1x9gknd 8399 17 with with IN cord-010119-t1x9gknd 8399 18 low low JJ cord-010119-t1x9gknd 8399 19 risk risk NN cord-010119-t1x9gknd 8399 20 of of IN cord-010119-t1x9gknd 8399 21 contamination contamination NN cord-010119-t1x9gknd 8399 22 or or CC cord-010119-t1x9gknd 8399 23 hemolysis hemolysis NN cord-010119-t1x9gknd 8399 24 . . . cord-010119-t1x9gknd 8400 1 The the DT cord-010119-t1x9gknd 8400 2 flow flow NN cord-010119-t1x9gknd 8400 3 cytometry cytometry NN cord-010119-t1x9gknd 8400 4 assay assay NN cord-010119-t1x9gknd 8400 5 can can MD cord-010119-t1x9gknd 8400 6 detect detect VB cord-010119-t1x9gknd 8400 7 Bio Bio NNP cord-010119-t1x9gknd 8400 8 - - HYPH cord-010119-t1x9gknd 8400 9 RBC RBC NNP cord-010119-t1x9gknd 8400 10 in in IN cord-010119-t1x9gknd 8400 11 unlabeled unlabeled JJ cord-010119-t1x9gknd 8400 12 blood blood NN cord-010119-t1x9gknd 8400 13 at at IN cord-010119-t1x9gknd 8400 14 very very RB cord-010119-t1x9gknd 8400 15 low low JJ cord-010119-t1x9gknd 8400 16 frequency frequency NN cord-010119-t1x9gknd 8400 17 . . . cord-010119-t1x9gknd 8401 1 We -PRON- PRP cord-010119-t1x9gknd 8401 2 plan plan VBP cord-010119-t1x9gknd 8401 3 to to TO cord-010119-t1x9gknd 8401 4 use use VB cord-010119-t1x9gknd 8401 5 this this DT cord-010119-t1x9gknd 8401 6 technology technology NN cord-010119-t1x9gknd 8401 7 to to TO cord-010119-t1x9gknd 8401 8 study study VB cord-010119-t1x9gknd 8401 9 the the DT cord-010119-t1x9gknd 8401 10 impact impact NN cord-010119-t1x9gknd 8401 11 of of IN cord-010119-t1x9gknd 8401 12 donor donor NN cord-010119-t1x9gknd 8401 13 characteristic characteristic NN cord-010119-t1x9gknd 8401 14 on on IN cord-010119-t1x9gknd 8401 15 RBC RBC NNP cord-010119-t1x9gknd 8401 16 storage storage NN cord-010119-t1x9gknd 8401 17 stability stability NN cord-010119-t1x9gknd 8401 18 and and CC cord-010119-t1x9gknd 8401 19 post post JJ cord-010119-t1x9gknd 8401 20 - - JJ cord-010119-t1x9gknd 8401 21 transfusion transfusion JJ cord-010119-t1x9gknd 8401 22 survival survival NN cord-010119-t1x9gknd 8401 23 . . . cord-010119-t1x9gknd 8402 1 Background Background NNP cord-010119-t1x9gknd 8402 2 / / SYM cord-010119-t1x9gknd 8402 3 Case Case NNP cord-010119-t1x9gknd 8402 4 Studies Studies NNPS cord-010119-t1x9gknd 8402 5 : : : cord-010119-t1x9gknd 8403 1 Blood blood NN cord-010119-t1x9gknd 8403 2 products product NNS cord-010119-t1x9gknd 8403 3 offer offer VBP cord-010119-t1x9gknd 8403 4 resuscitation resuscitation NN cord-010119-t1x9gknd 8403 5 benefits benefit NNS cord-010119-t1x9gknd 8403 6 in in IN cord-010119-t1x9gknd 8403 7 trauma trauma NN cord-010119-t1x9gknd 8403 8 over over IN cord-010119-t1x9gknd 8403 9 crystalloid crystalloid NNP cord-010119-t1x9gknd 8403 10 / / SYM cord-010119-t1x9gknd 8403 11 colloid colloid NN cord-010119-t1x9gknd 8403 12 volume volume NN cord-010119-t1x9gknd 8403 13 expanders expander NNS cord-010119-t1x9gknd 8403 14 ( ( -LRB- cord-010119-t1x9gknd 8403 15 which which WDT cord-010119-t1x9gknd 8403 16 provide provide VBP cord-010119-t1x9gknd 8403 17 no no DT cord-010119-t1x9gknd 8403 18 hemostatic hemostatic JJ cord-010119-t1x9gknd 8403 19 benefit benefit NN cord-010119-t1x9gknd 8403 20 or or CC cord-010119-t1x9gknd 8403 21 oxygen oxygen NN cord-010119-t1x9gknd 8403 22 delivery delivery NN cord-010119-t1x9gknd 8403 23 ) ) -RRB- cord-010119-t1x9gknd 8403 24 , , , cord-010119-t1x9gknd 8403 25 but but CC cord-010119-t1x9gknd 8403 26 usage usage NN cord-010119-t1x9gknd 8403 27 is be VBZ cord-010119-t1x9gknd 8403 28 often often RB cord-010119-t1x9gknd 8403 29 hampered hamper VBN cord-010119-t1x9gknd 8403 30 by by IN cord-010119-t1x9gknd 8403 31 supply supply NN cord-010119-t1x9gknd 8403 32 or or CC cord-010119-t1x9gknd 8403 33 storage storage NN cord-010119-t1x9gknd 8403 34 needs need NNS cord-010119-t1x9gknd 8403 35 . . . cord-010119-t1x9gknd 8404 1 Hemoglobin hemoglobin NN cord-010119-t1x9gknd 8404 2 - - HYPH cord-010119-t1x9gknd 8404 3 based base VBN cord-010119-t1x9gknd 8404 4 oxygen oxygen NN cord-010119-t1x9gknd 8404 5 carriers carrier NNS cord-010119-t1x9gknd 8404 6 ( ( -LRB- cord-010119-t1x9gknd 8404 7 HBOCs HBOCs NNP cord-010119-t1x9gknd 8404 8 ) ) -RRB- cord-010119-t1x9gknd 8404 9 are be VBP cord-010119-t1x9gknd 8404 10 not not RB cord-010119-t1x9gknd 8404 11 red red JJ cord-010119-t1x9gknd 8404 12 cell cell NN cord-010119-t1x9gknd 8404 13 replacements replacement NNS cord-010119-t1x9gknd 8404 14 but but CC cord-010119-t1x9gknd 8404 15 may may MD cord-010119-t1x9gknd 8404 16 supplement supplement VB cord-010119-t1x9gknd 8404 17 oxygen oxygen NN cord-010119-t1x9gknd 8404 18 delivery delivery NN cord-010119-t1x9gknd 8404 19 and and CC cord-010119-t1x9gknd 8404 20 expand expand VB cord-010119-t1x9gknd 8404 21 volume volume NN cord-010119-t1x9gknd 8404 22 during during IN cord-010119-t1x9gknd 8404 23 transport transport NN cord-010119-t1x9gknd 8404 24 until until IN cord-010119-t1x9gknd 8404 25 blood blood NN cord-010119-t1x9gknd 8404 26 is be VBZ cord-010119-t1x9gknd 8404 27 available available JJ cord-010119-t1x9gknd 8404 28 . . . cord-010119-t1x9gknd 8405 1 Since since IN cord-010119-t1x9gknd 8405 2 hemostasis hemostasis NN cord-010119-t1x9gknd 8405 3 is be VBZ cord-010119-t1x9gknd 8405 4 critical critical JJ cord-010119-t1x9gknd 8405 5 in in IN cord-010119-t1x9gknd 8405 6 resuscitation resuscitation NN cord-010119-t1x9gknd 8405 7 , , , cord-010119-t1x9gknd 8405 8 this this DT cord-010119-t1x9gknd 8405 9 study study NN cord-010119-t1x9gknd 8405 10 evaluated evaluate VBD cord-010119-t1x9gknd 8405 11 bovine bovine JJ cord-010119-t1x9gknd 8405 12 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8405 13 glutamer-250 glutamer-250 NN cord-010119-t1x9gknd 8405 14 ( ( -LRB- cord-010119-t1x9gknd 8405 15 HBOC-201 HBOC-201 NNS cord-010119-t1x9gknd 8405 16 ) ) -RRB- cord-010119-t1x9gknd 8405 17 effects effect NNS cord-010119-t1x9gknd 8405 18 on on IN cord-010119-t1x9gknd 8405 19 coagulation coagulation NN cord-010119-t1x9gknd 8405 20 parameters parameter NNS cord-010119-t1x9gknd 8405 21 alongside alongside IN cord-010119-t1x9gknd 8405 22 freeze freeze NN cord-010119-t1x9gknd 8405 23 - - HYPH cord-010119-t1x9gknd 8405 24 dried dry VBN cord-010119-t1x9gknd 8405 25 plasma plasma NN cord-010119-t1x9gknd 8405 26 ( ( -LRB- cord-010119-t1x9gknd 8405 27 FDP FDP NNP cord-010119-t1x9gknd 8405 28 ) ) -RRB- cord-010119-t1x9gknd 8405 29 in in IN cord-010119-t1x9gknd 8405 30 an an DT cord-010119-t1x9gknd 8405 31 in in FW cord-010119-t1x9gknd 8405 32 vitro vitro FW cord-010119-t1x9gknd 8405 33 model model NN cord-010119-t1x9gknd 8405 34 of of IN cord-010119-t1x9gknd 8405 35 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8405 36 / / SYM cord-010119-t1x9gknd 8405 37 resuscitation resuscitation NN cord-010119-t1x9gknd 8405 38 . . . cord-010119-t1x9gknd 8406 1 Study Study NNP cord-010119-t1x9gknd 8406 2 Design Design NNP cord-010119-t1x9gknd 8406 3 / / SYM cord-010119-t1x9gknd 8406 4 Method method NN cord-010119-t1x9gknd 8406 5 : : : cord-010119-t1x9gknd 8407 1 Whole whole JJ cord-010119-t1x9gknd 8407 2 blood blood NN cord-010119-t1x9gknd 8407 3 ( ( -LRB- cord-010119-t1x9gknd 8407 4 WB WB NNP cord-010119-t1x9gknd 8407 5 ) ) -RRB- cord-010119-t1x9gknd 8407 6 was be VBD cord-010119-t1x9gknd 8407 7 collected collect VBN cord-010119-t1x9gknd 8407 8 from from IN cord-010119-t1x9gknd 8407 9 healthy healthy JJ cord-010119-t1x9gknd 8407 10 donors donor NNS cord-010119-t1x9gknd 8407 11 under under IN cord-010119-t1x9gknd 8407 12 an an DT cord-010119-t1x9gknd 8407 13 approved approve VBN cord-010119-t1x9gknd 8407 14 institutional institutional JJ cord-010119-t1x9gknd 8407 15 standard standard JJ cord-010119-t1x9gknd 8407 16 operating operating NN cord-010119-t1x9gknd 8407 17 procedure procedure NN cord-010119-t1x9gknd 8407 18 . . . cord-010119-t1x9gknd 8408 1 In in IN cord-010119-t1x9gknd 8408 2 the the DT cord-010119-t1x9gknd 8408 3 first first JJ cord-010119-t1x9gknd 8408 4 study study NN cord-010119-t1x9gknd 8408 5 ( ( -LRB- cord-010119-t1x9gknd 8408 6 limited limited JJ cord-010119-t1x9gknd 8408 7 resuscitation resuscitation NN cord-010119-t1x9gknd 8408 8 ) ) -RRB- cord-010119-t1x9gknd 8408 9 , , , cord-010119-t1x9gknd 8408 10 samples sample NNS cord-010119-t1x9gknd 8408 11 were be VBD cord-010119-t1x9gknd 8408 12 : : : cord-010119-t1x9gknd 8408 13 ( ( -LRB- cord-010119-t1x9gknd 8408 14 1 1 LS cord-010119-t1x9gknd 8408 15 ) ) -RRB- cord-010119-t1x9gknd 8408 16 WB WB NNP cord-010119-t1x9gknd 8408 17 , , , cord-010119-t1x9gknd 8408 18 ( ( -LRB- cord-010119-t1x9gknd 8408 19 2 2 LS cord-010119-t1x9gknd 8408 20 ) ) -RRB- cord-010119-t1x9gknd 8409 1 WB110 wb110 CD cord-010119-t1x9gknd 8409 2 % % NN cord-010119-t1x9gknd 8409 3 HBOC hboc NN cord-010119-t1x9gknd 8409 4 volume volume NN cord-010119-t1x9gknd 8409 5 ( ( -LRB- cord-010119-t1x9gknd 8409 6 model model NN cord-010119-t1x9gknd 8409 7 of of IN cord-010119-t1x9gknd 8409 8 two two CD cord-010119-t1x9gknd 8409 9 units unit NNS cord-010119-t1x9gknd 8409 10 in in IN cord-010119-t1x9gknd 8409 11 an an DT cord-010119-t1x9gknd 8409 12 adult adult NN cord-010119-t1x9gknd 8409 13 ) ) -RRB- cord-010119-t1x9gknd 8409 14 , , , cord-010119-t1x9gknd 8409 15 ( ( -LRB- cord-010119-t1x9gknd 8409 16 3 3 LS cord-010119-t1x9gknd 8409 17 ) ) -RRB- cord-010119-t1x9gknd 8410 1 WB110 wb110 CD cord-010119-t1x9gknd 8410 2 % % NN cord-010119-t1x9gknd 8410 3 FDP FDP NNP cord-010119-t1x9gknd 8410 4 , , , cord-010119-t1x9gknd 8410 5 and and CC cord-010119-t1x9gknd 8410 6 ( ( -LRB- cord-010119-t1x9gknd 8410 7 4 4 LS cord-010119-t1x9gknd 8410 8 ) ) -RRB- cord-010119-t1x9gknd 8411 1 WB110 wb110 CD cord-010119-t1x9gknd 8411 2 % % NN cord-010119-t1x9gknd 8412 1 HBOC110 HBOC110 NNP cord-010119-t1x9gknd 8412 2 % % NN cord-010119-t1x9gknd 8412 3 FDP FDP NNP cord-010119-t1x9gknd 8412 4 . . . cord-010119-t1x9gknd 8413 1 Samples sample NNS cord-010119-t1x9gknd 8413 2 ( ( -LRB- cord-010119-t1x9gknd 8413 3 5)-(8 5)-(8 CD cord-010119-t1x9gknd 8413 4 ) ) -RRB- cord-010119-t1x9gknd 8413 5 simulated simulate VBN cord-010119-t1x9gknd 8413 6 autoresuscitation autoresuscitation NN cord-010119-t1x9gknd 8413 7 by by IN cord-010119-t1x9gknd 8413 8 adding add VBG cord-010119-t1x9gknd 8413 9 25 25 CD cord-010119-t1x9gknd 8413 10 % % NN cord-010119-t1x9gknd 8413 11 plasmalyte plasmalyte NN cord-010119-t1x9gknd 8413 12 to to IN cord-010119-t1x9gknd 8413 13 1 1 CD cord-010119-t1x9gknd 8413 14 - - SYM cord-010119-t1x9gknd 8413 15 4 4 CD cord-010119-t1x9gknd 8413 16 . . . cord-010119-t1x9gknd 8414 1 Susceptibility susceptibility NN cord-010119-t1x9gknd 8414 2 to to IN cord-010119-t1x9gknd 8414 3 lysis lysis NN cord-010119-t1x9gknd 8414 4 was be VBD cord-010119-t1x9gknd 8414 5 tested test VBN cord-010119-t1x9gknd 8414 6 with with IN cord-010119-t1x9gknd 8414 7 75ng 75ng NN cord-010119-t1x9gknd 8414 8 / / SYM cord-010119-t1x9gknd 8414 9 ml ml NN cord-010119-t1x9gknd 8414 10 tissue tissue NN cord-010119-t1x9gknd 8414 11 plasminogen plasminogen NN cord-010119-t1x9gknd 8414 12 activator activator NN cord-010119-t1x9gknd 8414 13 ( ( -LRB- cord-010119-t1x9gknd 8414 14 tPA tPA NNP cord-010119-t1x9gknd 8414 15 ) ) -RRB- cord-010119-t1x9gknd 8414 16 . . . cord-010119-t1x9gknd 8415 1 Follow follow VB cord-010119-t1x9gknd 8415 2 - - HYPH cord-010119-t1x9gknd 8415 3 up up RP cord-010119-t1x9gknd 8415 4 studies study NNS cord-010119-t1x9gknd 8415 5 were be VBD cord-010119-t1x9gknd 8415 6 performed perform VBN cord-010119-t1x9gknd 8415 7 with with IN cord-010119-t1x9gknd 8415 8 severe severe JJ cord-010119-t1x9gknd 8415 9 resuscitation resuscitation NN cord-010119-t1x9gknd 8415 10 simulations simulation NNS cord-010119-t1x9gknd 8415 11 of of IN cord-010119-t1x9gknd 8415 12 50 50 CD cord-010119-t1x9gknd 8415 13 % % NN cord-010119-t1x9gknd 8415 14 , , , cord-010119-t1x9gknd 8415 15 60 60 CD cord-010119-t1x9gknd 8415 16 % % NN cord-010119-t1x9gknd 8415 17 , , , cord-010119-t1x9gknd 8415 18 75 75 CD cord-010119-t1x9gknd 8415 19 % % NN cord-010119-t1x9gknd 8415 20 , , , cord-010119-t1x9gknd 8415 21 and and CC cord-010119-t1x9gknd 8415 22 100 100 CD cord-010119-t1x9gknd 8415 23 % % NN cord-010119-t1x9gknd 8415 24 volume volume NN cord-010119-t1x9gknd 8415 25 replacement replacement NN cord-010119-t1x9gknd 8415 26 with with IN cord-010119-t1x9gknd 8415 27 HBOC HBOC NNP cord-010119-t1x9gknd 8415 28 and/or and/or CC cord-010119-t1x9gknd 8415 29 FDP FDP NNP cord-010119-t1x9gknd 8415 30 , , , cord-010119-t1x9gknd 8415 31 with with IN cord-010119-t1x9gknd 8415 32 or or CC cord-010119-t1x9gknd 8415 33 without without IN cord-010119-t1x9gknd 8415 34 prior prior JJ cord-010119-t1x9gknd 8415 35 25 25 CD cord-010119-t1x9gknd 8415 36 % % NN cord-010119-t1x9gknd 8415 37 plasmalyte plasmalyte NN cord-010119-t1x9gknd 8415 38 dilution dilution NN cord-010119-t1x9gknd 8415 39 . . . cord-010119-t1x9gknd 8416 1 Coagulation coagulation NN cord-010119-t1x9gknd 8416 2 parameters parameter NNS cord-010119-t1x9gknd 8416 3 were be VBD cord-010119-t1x9gknd 8416 4 obtained obtain VBN cord-010119-t1x9gknd 8416 5 with with IN cord-010119-t1x9gknd 8416 6 a a DT cord-010119-t1x9gknd 8416 7 coagulation coagulation NN cord-010119-t1x9gknd 8416 8 analyzer analyzer NN cord-010119-t1x9gknd 8416 9 and and CC cord-010119-t1x9gknd 8416 10 thromboelastography thromboelastography NNP cord-010119-t1x9gknd 8416 11 ( ( -LRB- cord-010119-t1x9gknd 8416 12 TEG TEG NNP cord-010119-t1x9gknd 8416 13 ) ) -RRB- cord-010119-t1x9gknd 8416 14 . . . cord-010119-t1x9gknd 8417 1 RBCs rbc NNS cord-010119-t1x9gknd 8417 2 / / SYM cord-010119-t1x9gknd 8417 3 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8417 4 were be VBD cord-010119-t1x9gknd 8417 5 measured measure VBN cord-010119-t1x9gknd 8417 6 on on IN cord-010119-t1x9gknd 8417 7 a a DT cord-010119-t1x9gknd 8417 8 hematology hematology NN cord-010119-t1x9gknd 8417 9 analyzer analyzer NN cord-010119-t1x9gknd 8417 10 . . . cord-010119-t1x9gknd 8418 1 Thrombin Thrombin NNP cord-010119-t1x9gknd 8418 2 generation generation NN cord-010119-t1x9gknd 8418 3 was be VBD cord-010119-t1x9gknd 8418 4 quantified quantify VBN cord-010119-t1x9gknd 8418 5 by by IN cord-010119-t1x9gknd 8418 6 thrombogram thrombogram NNP cord-010119-t1x9gknd 8418 7 . . . cord-010119-t1x9gknd 8419 1 Platelet platelet NN cord-010119-t1x9gknd 8419 2 aggregation aggregation NN cord-010119-t1x9gknd 8419 3 was be VBD cord-010119-t1x9gknd 8419 4 measured measure VBN cord-010119-t1x9gknd 8419 5 in in IN cord-010119-t1x9gknd 8419 6 Multiplate Multiplate NNP cord-010119-t1x9gknd 8419 7 and and CC cord-010119-t1x9gknd 8419 8 adhesion adhesion NN cord-010119-t1x9gknd 8419 9 to to IN cord-010119-t1x9gknd 8419 10 collagen collagen NN cord-010119-t1x9gknd 8419 11 under under IN cord-010119-t1x9gknd 8419 12 shear shear NN cord-010119-t1x9gknd 8419 13 in in IN cord-010119-t1x9gknd 8419 14 BioFlux BioFlux NNP cord-010119-t1x9gknd 8419 15 . . . cord-010119-t1x9gknd 8420 1 Viscosity viscosity NN cord-010119-t1x9gknd 8420 2 was be VBD cord-010119-t1x9gknd 8420 3 evaluated evaluate VBN cord-010119-t1x9gknd 8420 4 by by IN cord-010119-t1x9gknd 8420 5 rheology rheology NN cord-010119-t1x9gknd 8420 6 . . . cord-010119-t1x9gknd 8421 1 Results result NNS cord-010119-t1x9gknd 8421 2 / / SYM cord-010119-t1x9gknd 8421 3 Finding finding NN cord-010119-t1x9gknd 8421 4 : : : cord-010119-t1x9gknd 8422 1 A a DT cord-010119-t1x9gknd 8422 2 limited limited JJ cord-010119-t1x9gknd 8422 3 resuscitation resuscitation NN cord-010119-t1x9gknd 8422 4 model model NN cord-010119-t1x9gknd 8422 5 with with IN cord-010119-t1x9gknd 8422 6 HBOC HBOC NNP cord-010119-t1x9gknd 8423 1 and/or and/or CC cord-010119-t1x9gknd 8424 1 FDP FDP NNP cord-010119-t1x9gknd 8424 2 had have VBD cord-010119-t1x9gknd 8424 3 no no DT cord-010119-t1x9gknd 8424 4 effects effect NNS cord-010119-t1x9gknd 8424 5 on on IN cord-010119-t1x9gknd 8424 6 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8424 7 , , , cord-010119-t1x9gknd 8424 8 PT PT NNP cord-010119-t1x9gknd 8424 9 , , , cord-010119-t1x9gknd 8424 10 aPTT aPTT NNP cord-010119-t1x9gknd 8424 11 , , , cord-010119-t1x9gknd 8424 12 pH pH NNP cord-010119-t1x9gknd 8424 13 , , , cord-010119-t1x9gknd 8424 14 Hct Hct NNP cord-010119-t1x9gknd 8424 15 , , , cord-010119-t1x9gknd 8424 16 or or CC cord-010119-t1x9gknd 8424 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8424 18 . . . cord-010119-t1x9gknd 8425 1 In in IN cord-010119-t1x9gknd 8425 2 TEG TEG NNP cord-010119-t1x9gknd 8425 3 , , , cord-010119-t1x9gknd 8425 4 WB WB NNP cord-010119-t1x9gknd 8425 5 , , , cord-010119-t1x9gknd 8425 6 WB1HBOC WB1HBOC NNP cord-010119-t1x9gknd 8425 7 , , , cord-010119-t1x9gknd 8425 8 and and CC cord-010119-t1x9gknd 8425 9 WB1HBOC1FDP wb1hboc1fdp NN cord-010119-t1x9gknd 8425 10 had have VBD cord-010119-t1x9gknd 8425 11 reduced reduce VBN cord-010119-t1x9gknd 8425 12 clot clot NN cord-010119-t1x9gknd 8425 13 strength strength NN cord-010119-t1x9gknd 8425 14 with with IN cord-010119-t1x9gknd 8425 15 dilution dilution NN cord-010119-t1x9gknd 8425 16 and and CC cord-010119-t1x9gknd 8425 17 tPA tPA NNP cord-010119-t1x9gknd 8425 18 . . . cord-010119-t1x9gknd 8426 1 There there EX cord-010119-t1x9gknd 8426 2 was be VBD cord-010119-t1x9gknd 8426 3 increased increase VBN cord-010119-t1x9gknd 8426 4 susceptibility susceptibility NN cord-010119-t1x9gknd 8426 5 to to IN cord-010119-t1x9gknd 8426 6 tPA tPA NNP cord-010119-t1x9gknd 8426 7 - - HYPH cord-010119-t1x9gknd 8426 8 induced induce VBN cord-010119-t1x9gknd 8426 9 lysis lysis NN cord-010119-t1x9gknd 8426 10 between between IN cord-010119-t1x9gknd 8426 11 WB WB NNP cord-010119-t1x9gknd 8426 12 and and CC cord-010119-t1x9gknd 8426 13 WB1HBOC WB1HBOC NNP cord-010119-t1x9gknd 8426 14 in in IN cord-010119-t1x9gknd 8426 15 autodilution autodilution NNP cord-010119-t1x9gknd 8426 16 simulation simulation NN cord-010119-t1x9gknd 8426 17 ( ( -LRB- cord-010119-t1x9gknd 8426 18 mean mean VB cord-010119-t1x9gknd 8426 19 lysis lysis NN cord-010119-t1x9gknd 8426 20 4.79 4.79 CD cord-010119-t1x9gknd 8426 21 % % NN cord-010119-t1x9gknd 8426 22 vs. vs. NN cord-010119-t1x9gknd 8426 23 16.36 16.36 CD cord-010119-t1x9gknd 8426 24 % % NN cord-010119-t1x9gknd 8426 25 ; ; , cord-010119-t1x9gknd 8426 26 p<.05 p<.05 NNP cord-010119-t1x9gknd 8426 27 ) ) -RRB- cord-010119-t1x9gknd 8426 28 . . . cord-010119-t1x9gknd 8427 1 HBOC HBOC NNP cord-010119-t1x9gknd 8427 2 and and CC cord-010119-t1x9gknd 8427 3 FDP FDP NNP cord-010119-t1x9gknd 8427 4 had have VBD cord-010119-t1x9gknd 8427 5 no no DT cord-010119-t1x9gknd 8427 6 statistically statistically RB cord-010119-t1x9gknd 8427 7 significant significant JJ cord-010119-t1x9gknd 8427 8 impact impact NN cord-010119-t1x9gknd 8427 9 on on IN cord-010119-t1x9gknd 8427 10 thrombin thrombin JJ cord-010119-t1x9gknd 8427 11 generation generation NN cord-010119-t1x9gknd 8427 12 . . . cord-010119-t1x9gknd 8428 1 No no DT cord-010119-t1x9gknd 8428 2 effects effect NNS cord-010119-t1x9gknd 8428 3 on on IN cord-010119-t1x9gknd 8428 4 platelet platelet NN cord-010119-t1x9gknd 8428 5 aggregation aggregation NN cord-010119-t1x9gknd 8428 6 were be VBD cord-010119-t1x9gknd 8428 7 observed observe VBN cord-010119-t1x9gknd 8428 8 ; ; : cord-010119-t1x9gknd 8428 9 no no DT cord-010119-t1x9gknd 8428 10 significant significant JJ cord-010119-t1x9gknd 8428 11 differences difference NNS cord-010119-t1x9gknd 8428 12 within within IN cord-010119-t1x9gknd 8428 13 diluted dilute VBN cord-010119-t1x9gknd 8428 14 v. v. CC cord-010119-t1x9gknd 8428 15 undiluted undiluted JJ cord-010119-t1x9gknd 8428 16 groups group NNS cord-010119-t1x9gknd 8428 17 were be VBD cord-010119-t1x9gknd 8428 18 seen see VBN cord-010119-t1x9gknd 8428 19 in in IN cord-010119-t1x9gknd 8428 20 platelet platelet NN cord-010119-t1x9gknd 8428 21 adhesion adhesion NN cord-010119-t1x9gknd 8428 22 under under IN cord-010119-t1x9gknd 8428 23 flow flow NN cord-010119-t1x9gknd 8428 24 . . . cord-010119-t1x9gknd 8429 1 HBOC HBOC NNP cord-010119-t1x9gknd 8429 2 ( ( -LRB- cord-010119-t1x9gknd 8429 3 10 10 CD cord-010119-t1x9gknd 8429 4 % % NN cord-010119-t1x9gknd 8429 5 ) ) -RRB- cord-010119-t1x9gknd 8429 6 did do VBD cord-010119-t1x9gknd 8429 7 not not RB cord-010119-t1x9gknd 8429 8 significantly significantly RB cord-010119-t1x9gknd 8429 9 change change VB cord-010119-t1x9gknd 8429 10 viscosity viscosity NN cord-010119-t1x9gknd 8429 11 . . . cord-010119-t1x9gknd 8430 1 Severe severe JJ cord-010119-t1x9gknd 8430 2 resuscitation resuscitation NN cord-010119-t1x9gknd 8430 3 simulations simulation NNS cord-010119-t1x9gknd 8430 4 had have VBD cord-010119-t1x9gknd 8430 5 increased increase VBN cord-010119-t1x9gknd 8430 6 PT PT NNP cord-010119-t1x9gknd 8430 7 / / SYM cord-010119-t1x9gknd 8430 8 PTT PTT NNP cord-010119-t1x9gknd 8430 9 and and CC cord-010119-t1x9gknd 8430 10 reduced reduced JJ cord-010119-t1x9gknd 8430 11 clot clot NN cord-010119-t1x9gknd 8430 12 strength strength NN cord-010119-t1x9gknd 8430 13 , , , cord-010119-t1x9gknd 8430 14 particularly particularly RB cord-010119-t1x9gknd 8430 15 in in IN cord-010119-t1x9gknd 8430 16 HBOC hboc NN cord-010119-t1x9gknd 8430 17 - - HYPH cord-010119-t1x9gknd 8430 18 only only RB cord-010119-t1x9gknd 8430 19 resuscitation resuscitation NN cord-010119-t1x9gknd 8430 20 ; ; : cord-010119-t1x9gknd 8430 21 however however RB cord-010119-t1x9gknd 8430 22 , , , cord-010119-t1x9gknd 8430 23 even even RB cord-010119-t1x9gknd 8430 24 75 75 CD cord-010119-t1x9gknd 8430 25 % % NN cord-010119-t1x9gknd 8430 26 HBOC hboc NN cord-010119-t1x9gknd 8430 27 volume volume NN cord-010119-t1x9gknd 8430 28 replacement replacement NN cord-010119-t1x9gknd 8430 29 produced produce VBD cord-010119-t1x9gknd 8430 30 clots clot NNS cord-010119-t1x9gknd 8430 31 with with IN cord-010119-t1x9gknd 8430 32 acceptable acceptable JJ cord-010119-t1x9gknd 8430 33 TEG TEG NNP cord-010119-t1x9gknd 8430 34 parameters parameter NNS cord-010119-t1x9gknd 8430 35 . . . cord-010119-t1x9gknd 8431 1 Conclusion conclusion NN cord-010119-t1x9gknd 8431 2 : : : cord-010119-t1x9gknd 8432 1 In in IN cord-010119-t1x9gknd 8432 2 a a DT cord-010119-t1x9gknd 8432 3 limited limited JJ cord-010119-t1x9gknd 8432 4 resuscitation resuscitation NN cord-010119-t1x9gknd 8432 5 model model NN cord-010119-t1x9gknd 8432 6 with with IN cord-010119-t1x9gknd 8432 7 HBOC-201 HBOC-201 NNP cord-010119-t1x9gknd 8432 8 , , , cord-010119-t1x9gknd 8432 9 there there EX cord-010119-t1x9gknd 8432 10 were be VBD cord-010119-t1x9gknd 8432 11 no no DT cord-010119-t1x9gknd 8432 12 significant significant JJ cord-010119-t1x9gknd 8432 13 in in IN cord-010119-t1x9gknd 8432 14 vitro vitro FW cord-010119-t1x9gknd 8432 15 effects effect NNS cord-010119-t1x9gknd 8432 16 on on IN cord-010119-t1x9gknd 8432 17 hemostatic hemostatic JJ cord-010119-t1x9gknd 8432 18 parameters parameter NNS cord-010119-t1x9gknd 8432 19 ( ( -LRB- cord-010119-t1x9gknd 8432 20 except except IN cord-010119-t1x9gknd 8432 21 increased increase VBN cord-010119-t1x9gknd 8432 22 susceptibility susceptibility NN cord-010119-t1x9gknd 8432 23 to to IN cord-010119-t1x9gknd 8432 24 lysis lysis NN cord-010119-t1x9gknd 8432 25 ) ) -RRB- cord-010119-t1x9gknd 8432 26 ; ; : cord-010119-t1x9gknd 8432 27 more more RBR cord-010119-t1x9gknd 8432 28 severe severe JJ cord-010119-t1x9gknd 8432 29 resuscitations resuscitation NNS cord-010119-t1x9gknd 8432 30 impacted impact VBD cord-010119-t1x9gknd 8432 31 coagulation coagulation NN cord-010119-t1x9gknd 8432 32 parameters parameter NNS cord-010119-t1x9gknd 8432 33 but but CC cord-010119-t1x9gknd 8432 34 did do VBD cord-010119-t1x9gknd 8432 35 not not RB cord-010119-t1x9gknd 8432 36 prevent prevent VB cord-010119-t1x9gknd 8432 37 clotting clotting NN cord-010119-t1x9gknd 8432 38 . . . cord-010119-t1x9gknd 8433 1 Considering consider VBG cord-010119-t1x9gknd 8433 2 the the DT cord-010119-t1x9gknd 8433 3 large large JJ cord-010119-t1x9gknd 8433 4 impact impact NN cord-010119-t1x9gknd 8433 5 healthy healthy JJ cord-010119-t1x9gknd 8433 6 platelets platelet NNS cord-010119-t1x9gknd 8433 7 have have VBP cord-010119-t1x9gknd 8433 8 on on IN cord-010119-t1x9gknd 8433 9 coagulation coagulation NN cord-010119-t1x9gknd 8433 10 function function NN cord-010119-t1x9gknd 8433 11 , , , cord-010119-t1x9gknd 8433 12 further further RB cord-010119-t1x9gknd 8433 13 in in IN cord-010119-t1x9gknd 8433 14 vitro vitro FW cord-010119-t1x9gknd 8433 15 studies study NNS cord-010119-t1x9gknd 8433 16 with with IN cord-010119-t1x9gknd 8433 17 impaired impaired JJ cord-010119-t1x9gknd 8433 18 platelets platelet NNS cord-010119-t1x9gknd 8433 19 are be VBP cord-010119-t1x9gknd 8433 20 warranted warrant VBN cord-010119-t1x9gknd 8433 21 alongside alongside RB cord-010119-t1x9gknd 8433 22 in in IN cord-010119-t1x9gknd 8433 23 vivo vivo NNP cord-010119-t1x9gknd 8433 24 studies study NNS cord-010119-t1x9gknd 8433 25 of of IN cord-010119-t1x9gknd 8433 26 HBOC1plasma HBOC1plasma NNP cord-010119-t1x9gknd 8433 27 as as IN cord-010119-t1x9gknd 8433 28 initial initial JJ cord-010119-t1x9gknd 8433 29 resuscitation resuscitation NN cord-010119-t1x9gknd 8433 30 of of IN cord-010119-t1x9gknd 8433 31 hemorrhagic hemorrhagic JJ cord-010119-t1x9gknd 8433 32 shock shock NN cord-010119-t1x9gknd 8433 33 . . . cord-010119-t1x9gknd 8434 1 therapy therapy NN cord-010119-t1x9gknd 8434 2 in in IN cord-010119-t1x9gknd 8434 3 patients patient NNS cord-010119-t1x9gknd 8434 4 with with IN cord-010119-t1x9gknd 8434 5 acute acute JJ cord-010119-t1x9gknd 8434 6 major major JJ cord-010119-t1x9gknd 8434 7 bleeding bleeding NN cord-010119-t1x9gknd 8434 8 . . . cord-010119-t1x9gknd 8435 1 While while IN cord-010119-t1x9gknd 8435 2 published publish VBN cord-010119-t1x9gknd 8435 3 literature literature NN cord-010119-t1x9gknd 8435 4 has have VBZ cord-010119-t1x9gknd 8435 5 largely largely RB cord-010119-t1x9gknd 8435 6 focused focus VBN cord-010119-t1x9gknd 8435 7 on on IN cord-010119-t1x9gknd 8435 8 the the DT cord-010119-t1x9gknd 8435 9 efficacy efficacy NN cord-010119-t1x9gknd 8435 10 and and CC cord-010119-t1x9gknd 8435 11 safety safety NN cord-010119-t1x9gknd 8435 12 of of IN cord-010119-t1x9gknd 8435 13 PCC PCC NNP cord-010119-t1x9gknd 8435 14 , , , cord-010119-t1x9gknd 8435 15 actual actual JJ cord-010119-t1x9gknd 8435 16 usage usage NN cord-010119-t1x9gknd 8435 17 practices practice NNS cord-010119-t1x9gknd 8435 18 are be VBP cord-010119-t1x9gknd 8435 19 less less RBR cord-010119-t1x9gknd 8435 20 characterized characterize VBN cord-010119-t1x9gknd 8435 21 . . . cord-010119-t1x9gknd 8436 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8436 2 aim aim NN cord-010119-t1x9gknd 8436 3 was be VBD cord-010119-t1x9gknd 8436 4 to to TO cord-010119-t1x9gknd 8436 5 describe describe VB cord-010119-t1x9gknd 8436 6 the the DT cord-010119-t1x9gknd 8436 7 PCC PCC NNP cord-010119-t1x9gknd 8436 8 usage usage NN cord-010119-t1x9gknd 8436 9 practices practice NNS cord-010119-t1x9gknd 8436 10 within within IN cord-010119-t1x9gknd 8436 11 a a DT cord-010119-t1x9gknd 8436 12 tertiary tertiary JJ cord-010119-t1x9gknd 8436 13 care care NN cord-010119-t1x9gknd 8436 14 center center NN cord-010119-t1x9gknd 8436 15 . . . cord-010119-t1x9gknd 8437 1 Study Study NNP cord-010119-t1x9gknd 8437 2 Design Design NNP cord-010119-t1x9gknd 8437 3 / / SYM cord-010119-t1x9gknd 8437 4 Method method NN cord-010119-t1x9gknd 8437 5 : : : cord-010119-t1x9gknd 8437 6 We -PRON- PRP cord-010119-t1x9gknd 8437 7 conducted conduct VBD cord-010119-t1x9gknd 8437 8 a a DT cord-010119-t1x9gknd 8437 9 retrospective retrospective JJ cord-010119-t1x9gknd 8437 10 review review NN cord-010119-t1x9gknd 8437 11 of of IN cord-010119-t1x9gknd 8437 12 the the DT cord-010119-t1x9gknd 8437 13 electronic electronic JJ cord-010119-t1x9gknd 8437 14 medical medical JJ cord-010119-t1x9gknd 8437 15 records record NNS cord-010119-t1x9gknd 8437 16 of of IN cord-010119-t1x9gknd 8437 17 patients patient NNS cord-010119-t1x9gknd 8437 18 who who WP cord-010119-t1x9gknd 8437 19 received receive VBD cord-010119-t1x9gknd 8437 20 PCC PCC NNP cord-010119-t1x9gknd 8437 21 between between IN cord-010119-t1x9gknd 8437 22 its -PRON- PRP$ cord-010119-t1x9gknd 8437 23 addition addition NN cord-010119-t1x9gknd 8437 24 to to IN cord-010119-t1x9gknd 8437 25 our -PRON- PRP$ cord-010119-t1x9gknd 8437 26 institution institution NN cord-010119-t1x9gknd 8437 27 's 's POS cord-010119-t1x9gknd 8437 28 formulary formulary NN cord-010119-t1x9gknd 8437 29 in in IN cord-010119-t1x9gknd 8437 30 8/2013 8/2013 CD cord-010119-t1x9gknd 8437 31 and and CC cord-010119-t1x9gknd 8437 32 2/2015 2/2015 CD cord-010119-t1x9gknd 8437 33 . . . cord-010119-t1x9gknd 8438 1 We -PRON- PRP cord-010119-t1x9gknd 8438 2 compiled compile VBD cord-010119-t1x9gknd 8438 3 information information NN cord-010119-t1x9gknd 8438 4 about about IN cord-010119-t1x9gknd 8438 5 the the DT cord-010119-t1x9gknd 8438 6 usage usage NN cord-010119-t1x9gknd 8438 7 of of IN cord-010119-t1x9gknd 8438 8 PCC PCC NNP cord-010119-t1x9gknd 8438 9 in in IN cord-010119-t1x9gknd 8438 10 these these DT cord-010119-t1x9gknd 8438 11 patients patient NNS cord-010119-t1x9gknd 8438 12 . . . cord-010119-t1x9gknd 8439 1 Descriptive descriptive JJ cord-010119-t1x9gknd 8439 2 statistics statistic NNS cord-010119-t1x9gknd 8439 3 were be VBD cord-010119-t1x9gknd 8439 4 generated generate VBN cord-010119-t1x9gknd 8439 5 with with IN cord-010119-t1x9gknd 8439 6 Microsoft Microsoft NNP cord-010119-t1x9gknd 8439 7 Excel Excel NNP cord-010119-t1x9gknd 8439 8 . . . cord-010119-t1x9gknd 8440 1 Results result NNS cord-010119-t1x9gknd 8440 2 / / SYM cord-010119-t1x9gknd 8440 3 Finding finding NN cord-010119-t1x9gknd 8440 4 : : : cord-010119-t1x9gknd 8441 1 Of of IN cord-010119-t1x9gknd 8441 2 81 81 CD cord-010119-t1x9gknd 8441 3 patients patient NNS cord-010119-t1x9gknd 8441 4 , , , cord-010119-t1x9gknd 8441 5 24 24 CD cord-010119-t1x9gknd 8441 6 were be VBD cord-010119-t1x9gknd 8441 7 on on IN cord-010119-t1x9gknd 8441 8 warfarin warfarin NN cord-010119-t1x9gknd 8441 9 . . . cord-010119-t1x9gknd 8442 1 PCC PCC NNP cord-010119-t1x9gknd 8442 2 was be VBD cord-010119-t1x9gknd 8442 3 most most RBS cord-010119-t1x9gknd 8442 4 frequently frequently RB cord-010119-t1x9gknd 8442 5 prescribed prescribe VBN cord-010119-t1x9gknd 8442 6 for for IN cord-010119-t1x9gknd 8442 7 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8442 8 due due IN cord-010119-t1x9gknd 8442 9 to to IN cord-010119-t1x9gknd 8442 10 surgery surgery NN cord-010119-t1x9gknd 8442 11 ( ( -LRB- cord-010119-t1x9gknd 8442 12 43 43 CD cord-010119-t1x9gknd 8442 13 % % NN cord-010119-t1x9gknd 8442 14 ) ) -RRB- cord-010119-t1x9gknd 8442 15 . . . cord-010119-t1x9gknd 8443 1 PCC PCC NNP cord-010119-t1x9gknd 8443 2 was be VBD cord-010119-t1x9gknd 8443 3 given give VBN cord-010119-t1x9gknd 8443 4 for for IN cord-010119-t1x9gknd 8443 5 warfarin warfarin JJ cord-010119-t1x9gknd 8443 6 reversal reversal NN cord-010119-t1x9gknd 8443 7 in in IN cord-010119-t1x9gknd 8443 8 31 31 CD cord-010119-t1x9gknd 8443 9 % % NN cord-010119-t1x9gknd 8443 10 of of IN cord-010119-t1x9gknd 8443 11 cases case NNS cord-010119-t1x9gknd 8443 12 . . . cord-010119-t1x9gknd 8444 1 A a DT cord-010119-t1x9gknd 8444 2 subset subset NN cord-010119-t1x9gknd 8444 3 of of IN cord-010119-t1x9gknd 8444 4 patients patient NNS cord-010119-t1x9gknd 8444 5 received receive VBD cord-010119-t1x9gknd 8444 6 plasma plasma NN cord-010119-t1x9gknd 8444 7 within within IN cord-010119-t1x9gknd 8444 8 2 2 CD cord-010119-t1x9gknd 8444 9 hours hour NNS cord-010119-t1x9gknd 8444 10 prior prior RB cord-010119-t1x9gknd 8444 11 to to IN cord-010119-t1x9gknd 8444 12 PCC PCC NNP cord-010119-t1x9gknd 8444 13 ( ( -LRB- cord-010119-t1x9gknd 8444 14 40 40 CD cord-010119-t1x9gknd 8444 15 % % NN cord-010119-t1x9gknd 8444 16 ) ) -RRB- cord-010119-t1x9gknd 8444 17 or or CC cord-010119-t1x9gknd 8444 18 24 24 CD cord-010119-t1x9gknd 8444 19 hours hour NNS cord-010119-t1x9gknd 8444 20 after after IN cord-010119-t1x9gknd 8444 21 ( ( -LRB- cord-010119-t1x9gknd 8444 22 47 47 CD cord-010119-t1x9gknd 8444 23 % % NN cord-010119-t1x9gknd 8444 24 ) ) -RRB- cord-010119-t1x9gknd 8444 25 . . . cord-010119-t1x9gknd 8445 1 PCC PCC NNP cord-010119-t1x9gknd 8445 2 was be VBD cord-010119-t1x9gknd 8445 3 most most RBS cord-010119-t1x9gknd 8445 4 frequently frequently RB cord-010119-t1x9gknd 8445 5 ordered order VBN cord-010119-t1x9gknd 8445 6 in in IN cord-010119-t1x9gknd 8445 7 the the DT cord-010119-t1x9gknd 8445 8 OR OR NNP cord-010119-t1x9gknd 8445 9 / / SYM cord-010119-t1x9gknd 8445 10 perioperative perioperative JJ cord-010119-t1x9gknd 8445 11 service service NN cord-010119-t1x9gknd 8445 12 ( ( -LRB- cord-010119-t1x9gknd 8445 13 25 25 CD cord-010119-t1x9gknd 8445 14 % % NN cord-010119-t1x9gknd 8445 15 ) ) -RRB- cord-010119-t1x9gknd 8445 16 . . . cord-010119-t1x9gknd 8446 1 Conclusion conclusion NN cord-010119-t1x9gknd 8446 2 : : : cord-010119-t1x9gknd 8447 1 The the DT cord-010119-t1x9gknd 8447 2 majority majority NN cord-010119-t1x9gknd 8447 3 of of IN cord-010119-t1x9gknd 8447 4 PCC PCC NNP cord-010119-t1x9gknd 8447 5 usage usage NN cord-010119-t1x9gknd 8447 6 was be VBD cord-010119-t1x9gknd 8447 7 " " `` cord-010119-t1x9gknd 8447 8 off off IN cord-010119-t1x9gknd 8447 9 - - HYPH cord-010119-t1x9gknd 8447 10 label label NN cord-010119-t1x9gknd 8447 11 " " '' cord-010119-t1x9gknd 8447 12 in in IN cord-010119-t1x9gknd 8447 13 terms term NNS cord-010119-t1x9gknd 8447 14 of of IN cord-010119-t1x9gknd 8447 15 being be VBG cord-010119-t1x9gknd 8447 16 prescribed prescribe VBN cord-010119-t1x9gknd 8447 17 for for IN cord-010119-t1x9gknd 8447 18 indications indication NNS cord-010119-t1x9gknd 8447 19 other other JJ cord-010119-t1x9gknd 8447 20 than than IN cord-010119-t1x9gknd 8447 21 warfarin warfarin JJ cord-010119-t1x9gknd 8447 22 reversal reversal NN cord-010119-t1x9gknd 8447 23 . . . cord-010119-t1x9gknd 8448 1 The the DT cord-010119-t1x9gknd 8448 2 most most RBS cord-010119-t1x9gknd 8448 3 frequent frequent JJ cord-010119-t1x9gknd 8448 4 indication indication NN cord-010119-t1x9gknd 8448 5 was be VBD cord-010119-t1x9gknd 8448 6 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8448 7 due due IN cord-010119-t1x9gknd 8448 8 to to IN cord-010119-t1x9gknd 8448 9 surgery surgery NN cord-010119-t1x9gknd 8448 10 , , , cord-010119-t1x9gknd 8448 11 and and CC cord-010119-t1x9gknd 8448 12 PCC PCC NNP cord-010119-t1x9gknd 8448 13 was be VBD cord-010119-t1x9gknd 8448 14 most most RBS cord-010119-t1x9gknd 8448 15 often often RB cord-010119-t1x9gknd 8448 16 ordered order VBN cord-010119-t1x9gknd 8448 17 in in IN cord-010119-t1x9gknd 8448 18 the the DT cord-010119-t1x9gknd 8448 19 OR OR NNP cord-010119-t1x9gknd 8448 20 / / SYM cord-010119-t1x9gknd 8448 21 perioperative perioperative JJ cord-010119-t1x9gknd 8448 22 service service NN cord-010119-t1x9gknd 8448 23 . . . cord-010119-t1x9gknd 8449 1 Although although IN cord-010119-t1x9gknd 8449 2 guidelines guideline NNS cord-010119-t1x9gknd 8449 3 recommend recommend VBP cord-010119-t1x9gknd 8449 4 the the DT cord-010119-t1x9gknd 8449 5 use use NN cord-010119-t1x9gknd 8449 6 of of IN cord-010119-t1x9gknd 8449 7 PCC PCC NNP cord-010119-t1x9gknd 8449 8 as as IN cord-010119-t1x9gknd 8449 9 a a DT cord-010119-t1x9gknd 8449 10 plasma plasma NN cord-010119-t1x9gknd 8449 11 alternative alternative NN cord-010119-t1x9gknd 8449 12 , , , cord-010119-t1x9gknd 8449 13 plasma plasma NN cord-010119-t1x9gknd 8449 14 was be VBD cord-010119-t1x9gknd 8449 15 administered administer VBN cord-010119-t1x9gknd 8449 16 within within IN cord-010119-t1x9gknd 8449 17 hours hour NNS cord-010119-t1x9gknd 8449 18 of of IN cord-010119-t1x9gknd 8449 19 PCC PCC NNP cord-010119-t1x9gknd 8449 20 in in IN cord-010119-t1x9gknd 8449 21 a a DT cord-010119-t1x9gknd 8449 22 notable notable JJ cord-010119-t1x9gknd 8449 23 subset subset NN cord-010119-t1x9gknd 8449 24 of of IN cord-010119-t1x9gknd 8449 25 patients patient NNS cord-010119-t1x9gknd 8449 26 . . . cord-010119-t1x9gknd 8450 1 Background Background NNP cord-010119-t1x9gknd 8450 2 / / SYM cord-010119-t1x9gknd 8450 3 Case Case NNP cord-010119-t1x9gknd 8450 4 Studies Studies NNPS cord-010119-t1x9gknd 8450 5 : : : cord-010119-t1x9gknd 8451 1 In in IN cord-010119-t1x9gknd 8451 2 Emergent emergent JJ cord-010119-t1x9gknd 8451 3 situations situation NNS cord-010119-t1x9gknd 8451 4 , , , cord-010119-t1x9gknd 8451 5 when when WRB cord-010119-t1x9gknd 8451 6 a a DT cord-010119-t1x9gknd 8451 7 patient patient NN cord-010119-t1x9gknd 8451 8 's 's POS cord-010119-t1x9gknd 8451 9 life life NN cord-010119-t1x9gknd 8451 10 may may MD cord-010119-t1x9gknd 8451 11 be be VB cord-010119-t1x9gknd 8451 12 jeopardized jeopardize VBN cord-010119-t1x9gknd 8451 13 by by IN cord-010119-t1x9gknd 8451 14 delaying delay VBG cord-010119-t1x9gknd 8451 15 transfusion transfusion NN cord-010119-t1x9gknd 8451 16 , , , cord-010119-t1x9gknd 8451 17 a a DT cord-010119-t1x9gknd 8451 18 physician physician NN cord-010119-t1x9gknd 8451 19 may may MD cord-010119-t1x9gknd 8451 20 decide decide VB cord-010119-t1x9gknd 8451 21 to to TO cord-010119-t1x9gknd 8451 22 transfuse transfuse VB cord-010119-t1x9gknd 8451 23 blood blood NN cord-010119-t1x9gknd 8451 24 emergently emergently RB cord-010119-t1x9gknd 8451 25 . . . cord-010119-t1x9gknd 8452 1 However however RB cord-010119-t1x9gknd 8452 2 , , , cord-010119-t1x9gknd 8452 3 in in IN cord-010119-t1x9gknd 8452 4 some some DT cord-010119-t1x9gknd 8452 5 cases case NNS cord-010119-t1x9gknd 8452 6 , , , cord-010119-t1x9gknd 8452 7 poor poor JJ cord-010119-t1x9gknd 8452 8 communication communication NN cord-010119-t1x9gknd 8452 9 and and CC cord-010119-t1x9gknd 8452 10 lack lack NN cord-010119-t1x9gknd 8452 11 of of IN cord-010119-t1x9gknd 8452 12 clear clear JJ cord-010119-t1x9gknd 8452 13 expectations expectation NNS cord-010119-t1x9gknd 8452 14 between between IN cord-010119-t1x9gknd 8452 15 the the DT cord-010119-t1x9gknd 8452 16 Blood Blood NNP cord-010119-t1x9gknd 8452 17 Bank Bank NNP cord-010119-t1x9gknd 8452 18 and and CC cord-010119-t1x9gknd 8452 19 patient patient JJ cord-010119-t1x9gknd 8452 20 care care NN cord-010119-t1x9gknd 8452 21 areas area NNS cord-010119-t1x9gknd 8452 22 can can MD cord-010119-t1x9gknd 8452 23 lead lead VB cord-010119-t1x9gknd 8452 24 to to IN cord-010119-t1x9gknd 8452 25 frustration frustration NN cord-010119-t1x9gknd 8452 26 and and CC cord-010119-t1x9gknd 8452 27 delays delay NNS cord-010119-t1x9gknd 8452 28 in in IN cord-010119-t1x9gknd 8452 29 the the DT cord-010119-t1x9gknd 8452 30 timely timely JJ cord-010119-t1x9gknd 8452 31 provision provision NN cord-010119-t1x9gknd 8452 32 of of IN cord-010119-t1x9gknd 8452 33 blood blood NN cord-010119-t1x9gknd 8452 34 products product NNS cord-010119-t1x9gknd 8452 35 . . . cord-010119-t1x9gknd 8453 1 An an DT cord-010119-t1x9gknd 8453 2 incident incident NN cord-010119-t1x9gknd 8453 3 prompted prompt VBD cord-010119-t1x9gknd 8453 4 an an DT cord-010119-t1x9gknd 8453 5 appraisal appraisal NN cord-010119-t1x9gknd 8453 6 of of IN cord-010119-t1x9gknd 8453 7 our -PRON- PRP$ cord-010119-t1x9gknd 8453 8 emergency emergency NN cord-010119-t1x9gknd 8453 9 release release NN cord-010119-t1x9gknd 8453 10 protocol protocol NN cord-010119-t1x9gknd 8453 11 ( ( -LRB- cord-010119-t1x9gknd 8453 12 ERP ERP NNP cord-010119-t1x9gknd 8453 13 ) ) -RRB- cord-010119-t1x9gknd 8453 14 , , , cord-010119-t1x9gknd 8453 15 which which WDT cord-010119-t1x9gknd 8453 16 revealed reveal VBD cord-010119-t1x9gknd 8453 17 gaps gap NNS cord-010119-t1x9gknd 8453 18 in in IN cord-010119-t1x9gknd 8453 19 communications communication NNS cord-010119-t1x9gknd 8453 20 and and CC cord-010119-t1x9gknd 8453 21 expectations expectation NNS cord-010119-t1x9gknd 8453 22 by by IN cord-010119-t1x9gknd 8453 23 both both CC cord-010119-t1x9gknd 8453 24 the the DT cord-010119-t1x9gknd 8453 25 Blood Blood NNP cord-010119-t1x9gknd 8453 26 Bank Bank NNP cord-010119-t1x9gknd 8453 27 and and CC cord-010119-t1x9gknd 8453 28 nursing nursing NN cord-010119-t1x9gknd 8453 29 personnel personnel NNS cord-010119-t1x9gknd 8453 30 . . . cord-010119-t1x9gknd 8454 1 Thus thus RB cord-010119-t1x9gknd 8454 2 , , , cord-010119-t1x9gknd 8454 3 it -PRON- PRP cord-010119-t1x9gknd 8454 4 is be VBZ cord-010119-t1x9gknd 8454 5 imperative imperative JJ cord-010119-t1x9gknd 8454 6 that that IN cord-010119-t1x9gknd 8454 7 there there EX cord-010119-t1x9gknd 8454 8 is be VBZ cord-010119-t1x9gknd 8454 9 a a DT cord-010119-t1x9gknd 8454 10 standardized standardized JJ cord-010119-t1x9gknd 8454 11 ER ER NNP cord-010119-t1x9gknd 8454 12 protocol protocol NN cord-010119-t1x9gknd 8454 13 with with IN cord-010119-t1x9gknd 8454 14 clear clear JJ cord-010119-t1x9gknd 8454 15 communications communication NNS cord-010119-t1x9gknd 8454 16 for for IN cord-010119-t1x9gknd 8454 17 both both CC cord-010119-t1x9gknd 8454 18 the the DT cord-010119-t1x9gknd 8454 19 Blood Blood NNP cord-010119-t1x9gknd 8454 20 Bank Bank NNP cord-010119-t1x9gknd 8454 21 and and CC cord-010119-t1x9gknd 8454 22 Nursing Nursing NNP cord-010119-t1x9gknd 8454 23 personnel personnel NNS cord-010119-t1x9gknd 8454 24 . . . cord-010119-t1x9gknd 8455 1 Reported report VBN cord-010119-t1x9gknd 8455 2 here here RB cord-010119-t1x9gknd 8455 3 is be VBZ cord-010119-t1x9gknd 8455 4 the the DT cord-010119-t1x9gknd 8455 5 outcome outcome NN cord-010119-t1x9gknd 8455 6 of of IN cord-010119-t1x9gknd 8455 7 a a DT cord-010119-t1x9gknd 8455 8 process process NN cord-010119-t1x9gknd 8455 9 improvement improvement NN cord-010119-t1x9gknd 8455 10 that that WDT cord-010119-t1x9gknd 8455 11 resulted result VBD cord-010119-t1x9gknd 8455 12 in in IN cord-010119-t1x9gknd 8455 13 improved improve VBN cord-010119-t1x9gknd 8455 14 communication communication NN cord-010119-t1x9gknd 8455 15 , , , cord-010119-t1x9gknd 8455 16 expectations expectation NNS cord-010119-t1x9gknd 8455 17 , , , cord-010119-t1x9gknd 8455 18 and and CC cord-010119-t1x9gknd 8455 19 turnaround turnaround NN cord-010119-t1x9gknd 8455 20 ( ( -LRB- cord-010119-t1x9gknd 8455 21 TAT tat NN cord-010119-t1x9gknd 8455 22 ) ) -RRB- cord-010119-t1x9gknd 8455 23 for for IN cord-010119-t1x9gknd 8455 24 our -PRON- PRP$ cord-010119-t1x9gknd 8455 25 ER ER NNP cord-010119-t1x9gknd 8455 26 protocol protocol NN cord-010119-t1x9gknd 8455 27 . . . cord-010119-t1x9gknd 8456 1 Study Study NNP cord-010119-t1x9gknd 8456 2 Design Design NNP cord-010119-t1x9gknd 8456 3 / / SYM cord-010119-t1x9gknd 8456 4 Method method NN cord-010119-t1x9gknd 8456 5 : : : cord-010119-t1x9gknd 8457 1 In in IN cord-010119-t1x9gknd 8457 2 2016 2016 CD cord-010119-t1x9gknd 8457 3 , , , cord-010119-t1x9gknd 8457 4 several several JJ cord-010119-t1x9gknd 8457 5 meetings meeting NNS cord-010119-t1x9gknd 8457 6 were be VBD cord-010119-t1x9gknd 8457 7 conducted conduct VBN cord-010119-t1x9gknd 8457 8 with with IN cord-010119-t1x9gknd 8457 9 stakeholders stakeholder NNS cord-010119-t1x9gknd 8457 10 ( ( -LRB- cord-010119-t1x9gknd 8457 11 Critical critical JJ cord-010119-t1x9gknd 8457 12 care care NN cord-010119-t1x9gknd 8457 13 units unit NNS cord-010119-t1x9gknd 8457 14 ( ( -LRB- cord-010119-t1x9gknd 8457 15 ICU ICU NNP cord-010119-t1x9gknd 8457 16 ) ) -RRB- cord-010119-t1x9gknd 8457 17 , , , cord-010119-t1x9gknd 8457 18 emergency emergency NN cord-010119-t1x9gknd 8457 19 department department NN cord-010119-t1x9gknd 8457 20 ( ( -LRB- cord-010119-t1x9gknd 8457 21 ED ED NNP cord-010119-t1x9gknd 8457 22 ) ) -RRB- cord-010119-t1x9gknd 8457 23 , , , cord-010119-t1x9gknd 8457 24 internal internal JJ cord-010119-t1x9gknd 8457 25 medicine medicine NN cord-010119-t1x9gknd 8457 26 , , , cord-010119-t1x9gknd 8457 27 interventional interventional JJ cord-010119-t1x9gknd 8457 28 radiology radiology NN cord-010119-t1x9gknd 8457 29 ( ( -LRB- cord-010119-t1x9gknd 8457 30 IR IR NNP cord-010119-t1x9gknd 8457 31 ) ) -RRB- cord-010119-t1x9gknd 8457 32 etc etc FW cord-010119-t1x9gknd 8457 33 . . . cord-010119-t1x9gknd 8457 34 ) ) -RRB- cord-010119-t1x9gknd 8458 1 in in IN cord-010119-t1x9gknd 8458 2 an an DT cord-010119-t1x9gknd 8458 3 effort effort NN cord-010119-t1x9gknd 8458 4 to to TO cord-010119-t1x9gknd 8458 5 identify identify VB cord-010119-t1x9gknd 8458 6 process process NN cord-010119-t1x9gknd 8458 7 gaps gap NNS cord-010119-t1x9gknd 8458 8 , , , cord-010119-t1x9gknd 8458 9 improve improve VB cord-010119-t1x9gknd 8458 10 communications communication NNS cord-010119-t1x9gknd 8458 11 , , , cord-010119-t1x9gknd 8458 12 and and CC cord-010119-t1x9gknd 8458 13 expectations expectation NNS cord-010119-t1x9gknd 8458 14 for for IN cord-010119-t1x9gknd 8458 15 ER ER NNP cord-010119-t1x9gknd 8458 16 episodes episode NNS cord-010119-t1x9gknd 8458 17 . . . cord-010119-t1x9gknd 8459 1 The the DT cord-010119-t1x9gknd 8459 2 goals goal NNS cord-010119-t1x9gknd 8459 3 was be VBD cord-010119-t1x9gknd 8459 4 to to TO cord-010119-t1x9gknd 8459 5 design design VB cord-010119-t1x9gknd 8459 6 a a DT cord-010119-t1x9gknd 8459 7 process process NN cord-010119-t1x9gknd 8459 8 for for IN cord-010119-t1x9gknd 8459 9 emergent emergent JJ cord-010119-t1x9gknd 8459 10 blood blood NN cord-010119-t1x9gknd 8459 11 product product NN cord-010119-t1x9gknd 8459 12 request request NN cord-010119-t1x9gknd 8459 13 and and CC cord-010119-t1x9gknd 8459 14 release release NN cord-010119-t1x9gknd 8459 15 in in IN cord-010119-t1x9gknd 8459 16 life life NN cord-010119-t1x9gknd 8459 17 threatening threaten VBG cord-010119-t1x9gknd 8459 18 situations situation NNS cord-010119-t1x9gknd 8459 19 that that WDT cord-010119-t1x9gknd 8459 20 will will MD cord-010119-t1x9gknd 8459 21 ; ; : cord-010119-t1x9gknd 8459 22 1 1 LS cord-010119-t1x9gknd 8459 23 ) ) -RRB- cord-010119-t1x9gknd 8459 24 Simplify simplify VB cord-010119-t1x9gknd 8459 25 and and CC cord-010119-t1x9gknd 8459 26 expedite expedite VB cord-010119-t1x9gknd 8459 27 the the DT cord-010119-t1x9gknd 8459 28 process process NN cord-010119-t1x9gknd 8459 29 ; ; : cord-010119-t1x9gknd 8459 30 2 2 LS cord-010119-t1x9gknd 8459 31 ) ) -RRB- cord-010119-t1x9gknd 8459 32 improve improve VB cord-010119-t1x9gknd 8459 33 communication communication NN cord-010119-t1x9gknd 8459 34 and and CC cord-010119-t1x9gknd 8459 35 expectations expectation NNS cord-010119-t1x9gknd 8459 36 to to TO cord-010119-t1x9gknd 8459 37 decrease decrease VB cord-010119-t1x9gknd 8459 38 TAT tat NN cord-010119-t1x9gknd 8459 39 ; ; : cord-010119-t1x9gknd 8459 40 3 3 LS cord-010119-t1x9gknd 8459 41 ) ) -RRB- cord-010119-t1x9gknd 8459 42 improve improve VB cord-010119-t1x9gknd 8459 43 patient patient JJ cord-010119-t1x9gknd 8459 44 safety safety NN cord-010119-t1x9gknd 8459 45 and and CC cord-010119-t1x9gknd 8459 46 meet meet VB cord-010119-t1x9gknd 8459 47 compliance compliance NN cord-010119-t1x9gknd 8459 48 . . . cord-010119-t1x9gknd 8460 1 In in IN cord-010119-t1x9gknd 8460 2 order order NN cord-010119-t1x9gknd 8460 3 to to TO cord-010119-t1x9gknd 8460 4 achieve achieve VB cord-010119-t1x9gknd 8460 5 these these DT cord-010119-t1x9gknd 8460 6 goals goal NNS cord-010119-t1x9gknd 8460 7 , , , cord-010119-t1x9gknd 8460 8 a a DT cord-010119-t1x9gknd 8460 9 series series NN cord-010119-t1x9gknd 8460 10 of of IN cord-010119-t1x9gknd 8460 11 activities activity NNS cord-010119-t1x9gknd 8460 12 were be VBD cord-010119-t1x9gknd 8460 13 conducted conduct VBN cord-010119-t1x9gknd 8460 14 . . . cord-010119-t1x9gknd 8461 1 These these DT cord-010119-t1x9gknd 8461 2 included include VBD cord-010119-t1x9gknd 8461 3 meetings meeting NNS cord-010119-t1x9gknd 8461 4 with with IN cord-010119-t1x9gknd 8461 5 all all DT cord-010119-t1x9gknd 8461 6 stakeholders stakeholder NNS cord-010119-t1x9gknd 8461 7 to to TO cord-010119-t1x9gknd 8461 8 ensure ensure VB cord-010119-t1x9gknd 8461 9 process process NN cord-010119-t1x9gknd 8461 10 improvement improvement NN cord-010119-t1x9gknd 8461 11 meet meet VB cord-010119-t1x9gknd 8461 12 the the DT cord-010119-t1x9gknd 8461 13 needs need NNS cord-010119-t1x9gknd 8461 14 intended intend VBN cord-010119-t1x9gknd 8461 15 . . . cord-010119-t1x9gknd 8462 1 A a DT cord-010119-t1x9gknd 8462 2 series series NN cord-010119-t1x9gknd 8462 3 of of IN cord-010119-t1x9gknd 8462 4 training training NN cord-010119-t1x9gknd 8462 5 sessions session NNS cord-010119-t1x9gknd 8462 6 with with IN cord-010119-t1x9gknd 8462 7 nurse nurse NN cord-010119-t1x9gknd 8462 8 educators educator NNS cord-010119-t1x9gknd 8462 9 in in IN cord-010119-t1x9gknd 8462 10 ICU ICU NNP cord-010119-t1x9gknd 8462 11 , , , cord-010119-t1x9gknd 8462 12 ED ED NNP cord-010119-t1x9gknd 8462 13 , , , cord-010119-t1x9gknd 8462 14 IR IR NNP cord-010119-t1x9gknd 8462 15 and and CC cord-010119-t1x9gknd 8462 16 Surgery surgery NN cord-010119-t1x9gknd 8463 1 managers manager NNS cord-010119-t1x9gknd 8463 2 were be VBD cord-010119-t1x9gknd 8463 3 conducted conduct VBN cord-010119-t1x9gknd 8463 4 . . . cord-010119-t1x9gknd 8464 1 During during IN cord-010119-t1x9gknd 8464 2 the the DT cord-010119-t1x9gknd 8464 3 meetings meeting NNS cord-010119-t1x9gknd 8464 4 , , , cord-010119-t1x9gknd 8464 5 communication communication NN cord-010119-t1x9gknd 8464 6 goals goal NNS cord-010119-t1x9gknd 8464 7 , , , cord-010119-t1x9gknd 8464 8 and and CC cord-010119-t1x9gknd 8464 9 expectations expectation NNS cord-010119-t1x9gknd 8464 10 were be VBD cord-010119-t1x9gknd 8464 11 defined define VBN cord-010119-t1x9gknd 8464 12 and and CC cord-010119-t1x9gknd 8464 13 agreed agree VBN cord-010119-t1x9gknd 8464 14 upon upon IN cord-010119-t1x9gknd 8464 15 . . . cord-010119-t1x9gknd 8465 1 Training training NN cord-010119-t1x9gknd 8465 2 sessions session NNS cord-010119-t1x9gknd 8465 3 included include VBD cord-010119-t1x9gknd 8465 4 PowerPoint PowerPoint NNP cord-010119-t1x9gknd 8465 5 presentations presentation NNS cord-010119-t1x9gknd 8465 6 to to TO cord-010119-t1x9gknd 8465 7 educate educate VB cord-010119-t1x9gknd 8465 8 staff staff NN cord-010119-t1x9gknd 8465 9 members member NNS cord-010119-t1x9gknd 8465 10 and and CC cord-010119-t1x9gknd 8465 11 performance performance NN cord-010119-t1x9gknd 8465 12 of of IN cord-010119-t1x9gknd 8465 13 dry dry JJ cord-010119-t1x9gknd 8465 14 runs run NNS cord-010119-t1x9gknd 8465 15 , , , cord-010119-t1x9gknd 8465 16 to to TO cord-010119-t1x9gknd 8465 17 identify identify VB cord-010119-t1x9gknd 8465 18 weaknesses weakness NNS cord-010119-t1x9gknd 8465 19 and and CC cord-010119-t1x9gknd 8465 20 strengths strength NNS cord-010119-t1x9gknd 8465 21 with with IN cord-010119-t1x9gknd 8465 22 the the DT cord-010119-t1x9gknd 8465 23 process process NN cord-010119-t1x9gknd 8465 24 flow flow NN cord-010119-t1x9gknd 8465 25 . . . cord-010119-t1x9gknd 8466 1 The the DT cord-010119-t1x9gknd 8466 2 impact impact NN cord-010119-t1x9gknd 8466 3 on on IN cord-010119-t1x9gknd 8466 4 the the DT cord-010119-t1x9gknd 8466 5 current current JJ cord-010119-t1x9gknd 8466 6 process process NN cord-010119-t1x9gknd 8466 7 was be VBD cord-010119-t1x9gknd 8466 8 analyzed analyze VBN cord-010119-t1x9gknd 8466 9 and and CC cord-010119-t1x9gknd 8466 10 , , , cord-010119-t1x9gknd 8466 11 as as IN cord-010119-t1x9gknd 8466 12 a a DT cord-010119-t1x9gknd 8466 13 result result NN cord-010119-t1x9gknd 8466 14 , , , cord-010119-t1x9gknd 8466 15 led lead VBD cord-010119-t1x9gknd 8466 16 to to IN cord-010119-t1x9gknd 8466 17 the the DT cord-010119-t1x9gknd 8466 18 revision revision NN cord-010119-t1x9gknd 8466 19 of of IN cord-010119-t1x9gknd 8466 20 the the DT cord-010119-t1x9gknd 8466 21 current current JJ cord-010119-t1x9gknd 8466 22 SOP sop NN cord-010119-t1x9gknd 8466 23 , , , cord-010119-t1x9gknd 8466 24 addition addition NN cord-010119-t1x9gknd 8466 25 of of IN cord-010119-t1x9gknd 8466 26 pre pre JJ cord-010119-t1x9gknd 8466 27 - - JJ cord-010119-t1x9gknd 8466 28 labeled label VBN cord-010119-t1x9gknd 8466 29 Emergency Emergency NNP cord-010119-t1x9gknd 8466 30 Pack Pack NNP cord-010119-t1x9gknd 8466 31 blood blood NN cord-010119-t1x9gknd 8466 32 ( ( -LRB- cord-010119-t1x9gknd 8466 33 4 4 CD cord-010119-t1x9gknd 8466 34 units unit NNS cord-010119-t1x9gknd 8466 35 of of IN cord-010119-t1x9gknd 8466 36 O O NNP cord-010119-t1x9gknd 8466 37 Neg Neg NNP cord-010119-t1x9gknd 8466 38 RBC RBC NNP cord-010119-t1x9gknd 8466 39 's 's POS cord-010119-t1x9gknd 8466 40 ) ) -RRB- cord-010119-t1x9gknd 8466 41 and and CC cord-010119-t1x9gknd 8466 42 implementation implementation NN cord-010119-t1x9gknd 8466 43 of of IN cord-010119-t1x9gknd 8466 44 an an DT cord-010119-t1x9gknd 8466 45 Electronic Electronic NNP cord-010119-t1x9gknd 8466 46 Emergency Emergency NNP cord-010119-t1x9gknd 8466 47 Blood Blood NNP cord-010119-t1x9gknd 8466 48 order order NN cord-010119-t1x9gknd 8466 49 set set NN cord-010119-t1x9gknd 8466 50 . . . cord-010119-t1x9gknd 8467 1 Results result NNS cord-010119-t1x9gknd 8467 2 / / SYM cord-010119-t1x9gknd 8467 3 Finding finding NN cord-010119-t1x9gknd 8467 4 : : : cord-010119-t1x9gknd 8467 5 In in IN cord-010119-t1x9gknd 8467 6 the the DT cord-010119-t1x9gknd 8467 7 ten ten CD cord-010119-t1x9gknd 8467 8 months month NNS cord-010119-t1x9gknd 8467 9 post post VBP cord-010119-t1x9gknd 8467 10 implementation implementation NN cord-010119-t1x9gknd 8467 11 of of IN cord-010119-t1x9gknd 8467 12 our -PRON- PRP$ cord-010119-t1x9gknd 8467 13 improved improved JJ cord-010119-t1x9gknd 8467 14 , , , cord-010119-t1x9gknd 8467 15 standardized standardized JJ cord-010119-t1x9gknd 8467 16 ER ER NNP cord-010119-t1x9gknd 8467 17 Pack Pack NNP cord-010119-t1x9gknd 8467 18 Protocol Protocol NNP cord-010119-t1x9gknd 8467 19 , , , cord-010119-t1x9gknd 8467 20 A a DT cord-010119-t1x9gknd 8467 21 total total NN cord-010119-t1x9gknd 8467 22 of of IN cord-010119-t1x9gknd 8467 23 61 61 CD cord-010119-t1x9gknd 8467 24 ER ER NNP cord-010119-t1x9gknd 8467 25 episodes episode NNS cord-010119-t1x9gknd 8467 26 were be VBD cord-010119-t1x9gknd 8467 27 received receive VBN cord-010119-t1x9gknd 8467 28 . . . cord-010119-t1x9gknd 8468 1 The the DT cord-010119-t1x9gknd 8468 2 average average JJ cord-010119-t1x9gknd 8468 3 TAT tat NN cord-010119-t1x9gknd 8468 4 from from IN cord-010119-t1x9gknd 8468 5 order order NN cord-010119-t1x9gknd 8468 6 to to IN cord-010119-t1x9gknd 8468 7 delivery delivery NN cord-010119-t1x9gknd 8468 8 at at IN cord-010119-t1x9gknd 8468 9 the the DT cord-010119-t1x9gknd 8468 10 bedside bedside NN cord-010119-t1x9gknd 8468 11 was be VBD cord-010119-t1x9gknd 8468 12 reduced reduce VBN cord-010119-t1x9gknd 8468 13 by by IN cord-010119-t1x9gknd 8468 14 50 50 CD cord-010119-t1x9gknd 8468 15 % % NN cord-010119-t1x9gknd 8468 16 ( ( -LRB- cord-010119-t1x9gknd 8468 17 7.0 7.0 CD cord-010119-t1x9gknd 8468 18 minutes minute NNS cord-010119-t1x9gknd 8468 19 compared compare VBN cord-010119-t1x9gknd 8468 20 to to IN cord-010119-t1x9gknd 8468 21 14 14 CD cord-010119-t1x9gknd 8468 22 minutes minute NNS cord-010119-t1x9gknd 8468 23 previously previously RB cord-010119-t1x9gknd 8468 24 ) ) -RRB- cord-010119-t1x9gknd 8468 25 , , , cord-010119-t1x9gknd 8468 26 while while IN cord-010119-t1x9gknd 8468 27 the the DT cord-010119-t1x9gknd 8468 28 compliance compliance NN cord-010119-t1x9gknd 8468 29 rate rate NN cord-010119-t1x9gknd 8468 30 for for IN cord-010119-t1x9gknd 8468 31 ER ER NNP cord-010119-t1x9gknd 8468 32 orders order NNS cord-010119-t1x9gknd 8468 33 and and CC cord-010119-t1x9gknd 8468 34 physician physician NN cord-010119-t1x9gknd 8468 35 documentation documentation NN cord-010119-t1x9gknd 8468 36 was be VBD cord-010119-t1x9gknd 8468 37 100 100 CD cord-010119-t1x9gknd 8468 38 % % NN cord-010119-t1x9gknd 8468 39 ( ( -LRB- cord-010119-t1x9gknd 8468 40 61/61 61/61 CD cord-010119-t1x9gknd 8468 41 ) ) -RRB- cord-010119-t1x9gknd 8468 42 , , , cord-010119-t1x9gknd 8468 43 with with IN cord-010119-t1x9gknd 8468 44 no no DT cord-010119-t1x9gknd 8468 45 current current JJ cord-010119-t1x9gknd 8468 46 wastage wastage NN cord-010119-t1x9gknd 8468 47 of of IN cord-010119-t1x9gknd 8468 48 blood blood NN cord-010119-t1x9gknd 8468 49 products product NNS cord-010119-t1x9gknd 8468 50 . . . cord-010119-t1x9gknd 8469 1 Conclusion conclusion NN cord-010119-t1x9gknd 8469 2 : : : cord-010119-t1x9gknd 8470 1 The the DT cord-010119-t1x9gknd 8470 2 implementation implementation NN cord-010119-t1x9gknd 8470 3 of of IN cord-010119-t1x9gknd 8470 4 the the DT cord-010119-t1x9gknd 8470 5 improved improved JJ cord-010119-t1x9gknd 8470 6 standardized standardized JJ cord-010119-t1x9gknd 8470 7 ER ER NNP cord-010119-t1x9gknd 8470 8 protocol protocol NN cord-010119-t1x9gknd 8470 9 significantly significantly RB cord-010119-t1x9gknd 8470 10 improved improve VBD cord-010119-t1x9gknd 8470 11 communications communication NNS cord-010119-t1x9gknd 8470 12 and and CC cord-010119-t1x9gknd 8470 13 expectations expectation NNS cord-010119-t1x9gknd 8470 14 , , , cord-010119-t1x9gknd 8470 15 decreased decrease VBD cord-010119-t1x9gknd 8470 16 TAT tat NN cord-010119-t1x9gknd 8470 17 and and CC cord-010119-t1x9gknd 8470 18 delays delay NNS cord-010119-t1x9gknd 8470 19 in in IN cord-010119-t1x9gknd 8470 20 transfusions transfusion NNS cord-010119-t1x9gknd 8470 21 while while IN cord-010119-t1x9gknd 8470 22 ensuring ensure VBG cord-010119-t1x9gknd 8470 23 patient patient JJ cord-010119-t1x9gknd 8470 24 safety safety NN cord-010119-t1x9gknd 8470 25 and and CC cord-010119-t1x9gknd 8470 26 compliance compliance NN cord-010119-t1x9gknd 8470 27 to to IN cord-010119-t1x9gknd 8470 28 regulatory regulatory JJ cord-010119-t1x9gknd 8470 29 requirements requirement NNS cord-010119-t1x9gknd 8470 30 . . . cord-010119-t1x9gknd 8471 1 Background Background NNP cord-010119-t1x9gknd 8471 2 / / SYM cord-010119-t1x9gknd 8471 3 Case Case NNP cord-010119-t1x9gknd 8471 4 Studies Studies NNPS cord-010119-t1x9gknd 8471 5 : : : cord-010119-t1x9gknd 8471 6 Massive massive JJ cord-010119-t1x9gknd 8471 7 transfusion transfusion NN cord-010119-t1x9gknd 8471 8 ( ( -LRB- cord-010119-t1x9gknd 8471 9 MT MT NNP cord-010119-t1x9gknd 8471 10 ) ) -RRB- cord-010119-t1x9gknd 8471 11 in in IN cord-010119-t1x9gknd 8471 12 the the DT cord-010119-t1x9gknd 8471 13 trauma trauma NN cord-010119-t1x9gknd 8471 14 setting setting NN cord-010119-t1x9gknd 8471 15 has have VBZ cord-010119-t1x9gknd 8471 16 been be VBN cord-010119-t1x9gknd 8471 17 extensively extensively RB cord-010119-t1x9gknd 8471 18 studied study VBN cord-010119-t1x9gknd 8471 19 . . . cord-010119-t1x9gknd 8472 1 Yet yet RB cord-010119-t1x9gknd 8472 2 , , , cord-010119-t1x9gknd 8472 3 the the DT cord-010119-t1x9gknd 8472 4 literature literature NN cord-010119-t1x9gknd 8472 5 in in IN cord-010119-t1x9gknd 8472 6 non non JJ cord-010119-t1x9gknd 8472 7 - - JJ cord-010119-t1x9gknd 8472 8 trauma trauma JJ cord-010119-t1x9gknd 8472 9 areas area NNS cord-010119-t1x9gknd 8472 10 , , , cord-010119-t1x9gknd 8472 11 especially especially RB cord-010119-t1x9gknd 8472 12 oncology oncology NN cord-010119-t1x9gknd 8472 13 is be VBZ cord-010119-t1x9gknd 8472 14 rather rather RB cord-010119-t1x9gknd 8472 15 sparse sparse JJ cord-010119-t1x9gknd 8472 16 . . . cord-010119-t1x9gknd 8473 1 The the DT cord-010119-t1x9gknd 8473 2 following following JJ cord-010119-t1x9gknd 8473 3 study study NN cord-010119-t1x9gknd 8473 4 was be VBD cord-010119-t1x9gknd 8473 5 conducted conduct VBN cord-010119-t1x9gknd 8473 6 to to TO cord-010119-t1x9gknd 8473 7 understand understand VB cord-010119-t1x9gknd 8473 8 the the DT cord-010119-t1x9gknd 8473 9 background background NN cord-010119-t1x9gknd 8473 10 and and CC cord-010119-t1x9gknd 8473 11 outcomes outcome NNS cord-010119-t1x9gknd 8473 12 of of IN cord-010119-t1x9gknd 8473 13 MT MT NNP cord-010119-t1x9gknd 8473 14 in in IN cord-010119-t1x9gknd 8473 15 cancer cancer NN cord-010119-t1x9gknd 8473 16 patients patient NNS cord-010119-t1x9gknd 8473 17 . . . cord-010119-t1x9gknd 8474 1 Study Study NNP cord-010119-t1x9gknd 8474 2 Design Design NNP cord-010119-t1x9gknd 8474 3 / / SYM cord-010119-t1x9gknd 8474 4 Methods method NNS cord-010119-t1x9gknd 8475 1 : : : cord-010119-t1x9gknd 8475 2 This this DT cord-010119-t1x9gknd 8475 3 was be VBD cord-010119-t1x9gknd 8475 4 a a DT cord-010119-t1x9gknd 8475 5 single single JJ cord-010119-t1x9gknd 8475 6 center center NN cord-010119-t1x9gknd 8475 7 retrospective retrospective JJ cord-010119-t1x9gknd 8475 8 study study NN cord-010119-t1x9gknd 8475 9 performed perform VBN cord-010119-t1x9gknd 8475 10 at at IN cord-010119-t1x9gknd 8475 11 a a DT cord-010119-t1x9gknd 8475 12 large large JJ cord-010119-t1x9gknd 8475 13 cancer cancer NN cord-010119-t1x9gknd 8475 14 center center NN cord-010119-t1x9gknd 8475 15 between between IN cord-010119-t1x9gknd 8475 16 February February NNP cord-010119-t1x9gknd 8475 17 2016 2016 CD cord-010119-t1x9gknd 8475 18 -February -February -RRB- cord-010119-t1x9gknd 8475 19 2017 2017 CD cord-010119-t1x9gknd 8475 20 . . . cord-010119-t1x9gknd 8476 1 MT MT NNP cord-010119-t1x9gknd 8476 2 was be VBD cord-010119-t1x9gknd 8476 3 defined define VBN cord-010119-t1x9gknd 8476 4 as as IN cord-010119-t1x9gknd 8476 5 the the DT cord-010119-t1x9gknd 8476 6 transfusion transfusion NN cord-010119-t1x9gknd 8476 7 of of IN cord-010119-t1x9gknd 8476 8 ! ! . cord-010119-t1x9gknd 8477 1 10 10 CD cord-010119-t1x9gknd 8477 2 RBC RBC NNP cord-010119-t1x9gknd 8477 3 units unit NNS cord-010119-t1x9gknd 8477 4 in in IN cord-010119-t1x9gknd 8477 5 a a DT cord-010119-t1x9gknd 8477 6 24-hour 24-hour JJ cord-010119-t1x9gknd 8477 7 period period NN cord-010119-t1x9gknd 8477 8 . . . cord-010119-t1x9gknd 8478 1 The the DT cord-010119-t1x9gknd 8478 2 following follow VBG cord-010119-t1x9gknd 8478 3 data datum NNS cord-010119-t1x9gknd 8478 4 were be VBD cord-010119-t1x9gknd 8478 5 collected collect VBN cord-010119-t1x9gknd 8478 6 included include VBN cord-010119-t1x9gknd 8478 7 : : : cord-010119-t1x9gknd 8478 8 age age NN cord-010119-t1x9gknd 8478 9 , , , cord-010119-t1x9gknd 8478 10 gender gender NN cord-010119-t1x9gknd 8478 11 , , , cord-010119-t1x9gknd 8478 12 primary primary JJ cord-010119-t1x9gknd 8478 13 diagnosis diagnosis NN cord-010119-t1x9gknd 8478 14 , , , cord-010119-t1x9gknd 8478 15 surgery surgery NN cord-010119-t1x9gknd 8478 16 or or CC cord-010119-t1x9gknd 8478 17 acute acute JJ cord-010119-t1x9gknd 8478 18 care care NN cord-010119-t1x9gknd 8478 19 type type NN cord-010119-t1x9gknd 8478 20 , , , cord-010119-t1x9gknd 8478 21 amount amount NN cord-010119-t1x9gknd 8478 22 and and CC cord-010119-t1x9gknd 8478 23 type type NN cord-010119-t1x9gknd 8478 24 of of IN cord-010119-t1x9gknd 8478 25 blood blood NN cord-010119-t1x9gknd 8478 26 components component NNS cord-010119-t1x9gknd 8478 27 transfused transfuse VBN cord-010119-t1x9gknd 8478 28 , , , cord-010119-t1x9gknd 8478 29 whether whether IN cord-010119-t1x9gknd 8478 30 or or CC cord-010119-t1x9gknd 8478 31 not not RB cord-010119-t1x9gknd 8478 32 a a DT cord-010119-t1x9gknd 8478 33 massive massive JJ cord-010119-t1x9gknd 8478 34 transfusion transfusion NN cord-010119-t1x9gknd 8478 35 protocol protocol NN cord-010119-t1x9gknd 8478 36 ( ( -LRB- cord-010119-t1x9gknd 8478 37 MTP MTP NNP cord-010119-t1x9gknd 8478 38 ) ) -RRB- cord-010119-t1x9gknd 8478 39 was be VBD cord-010119-t1x9gknd 8478 40 activated activate VBN cord-010119-t1x9gknd 8478 41 , , , cord-010119-t1x9gknd 8478 42 and and CC cord-010119-t1x9gknd 8478 43 survival survival NN cord-010119-t1x9gknd 8478 44 at at IN cord-010119-t1x9gknd 8478 45 30 30 CD cord-010119-t1x9gknd 8478 46 days day NNS cord-010119-t1x9gknd 8478 47 . . . cord-010119-t1x9gknd 8479 1 Results result NNS cord-010119-t1x9gknd 8479 2 / / SYM cord-010119-t1x9gknd 8479 3 Findings finding NNS cord-010119-t1x9gknd 8479 4 : : : cord-010119-t1x9gknd 8480 1 Thirty thirty CD cord-010119-t1x9gknd 8480 2 MTs mt NNS cord-010119-t1x9gknd 8480 3 occurred occur VBD cord-010119-t1x9gknd 8480 4 during during IN cord-010119-t1x9gknd 8480 5 a a DT cord-010119-t1x9gknd 8480 6 one one CD cord-010119-t1x9gknd 8480 7 year year NN cord-010119-t1x9gknd 8480 8 period period NN cord-010119-t1x9gknd 8480 9 . . . cord-010119-t1x9gknd 8481 1 A a DT cord-010119-t1x9gknd 8481 2 total total NN cord-010119-t1x9gknd 8481 3 of of IN cord-010119-t1x9gknd 8481 4 192,441 192,441 CD cord-010119-t1x9gknd 8481 5 blood blood NN cord-010119-t1x9gknd 8481 6 products product NNS cord-010119-t1x9gknd 8481 7 were be VBD cord-010119-t1x9gknd 8481 8 transfused transfuse VBN cord-010119-t1x9gknd 8481 9 during during IN cord-010119-t1x9gknd 8481 10 that that DT cord-010119-t1x9gknd 8481 11 time time NN cord-010119-t1x9gknd 8481 12 period period NN cord-010119-t1x9gknd 8481 13 . . . cord-010119-t1x9gknd 8482 1 Gender gender NN cord-010119-t1x9gknd 8482 2 distribution distribution NN cord-010119-t1x9gknd 8482 3 was be VBD cord-010119-t1x9gknd 8482 4 21/30 21/30 CD cord-010119-t1x9gknd 8482 5 ( ( -LRB- cord-010119-t1x9gknd 8482 6 70 70 CD cord-010119-t1x9gknd 8482 7 % % NN cord-010119-t1x9gknd 8482 8 ) ) -RRB- cord-010119-t1x9gknd 8482 9 males male NNS cord-010119-t1x9gknd 8482 10 , , , cord-010119-t1x9gknd 8482 11 and and CC cord-010119-t1x9gknd 8482 12 the the DT cord-010119-t1x9gknd 8482 13 average average JJ cord-010119-t1x9gknd 8482 14 age age NN cord-010119-t1x9gknd 8482 15 of of IN cord-010119-t1x9gknd 8482 16 all all DT cord-010119-t1x9gknd 8482 17 patients patient NNS cord-010119-t1x9gknd 8482 18 was be VBD cord-010119-t1x9gknd 8482 19 68 68 CD cord-010119-t1x9gknd 8482 20 with with IN cord-010119-t1x9gknd 8482 21 a a DT cord-010119-t1x9gknd 8482 22 range range NN cord-010119-t1x9gknd 8482 23 of of IN cord-010119-t1x9gknd 8482 24 21 21 CD cord-010119-t1x9gknd 8482 25 to to TO cord-010119-t1x9gknd 8482 26 70 70 CD cord-010119-t1x9gknd 8482 27 years year NNS cord-010119-t1x9gknd 8482 28 of of IN cord-010119-t1x9gknd 8482 29 age age NN cord-010119-t1x9gknd 8482 30 . . . cord-010119-t1x9gknd 8483 1 Surgical surgical JJ cord-010119-t1x9gknd 8483 2 patients patient NNS cord-010119-t1x9gknd 8483 3 accounted account VBD cord-010119-t1x9gknd 8483 4 for for IN cord-010119-t1x9gknd 8483 5 26/30 26/30 CD cord-010119-t1x9gknd 8483 6 ( ( -LRB- cord-010119-t1x9gknd 8483 7 86.7 86.7 CD cord-010119-t1x9gknd 8483 8 % % NN cord-010119-t1x9gknd 8483 9 ) ) -RRB- cord-010119-t1x9gknd 8483 10 MTs MTs NNP cord-010119-t1x9gknd 8483 11 , , , cord-010119-t1x9gknd 8483 12 and and CC cord-010119-t1x9gknd 8483 13 4/30 4/30 CD cord-010119-t1x9gknd 8483 14 ( ( -LRB- cord-010119-t1x9gknd 8483 15 13.3 13.3 CD cord-010119-t1x9gknd 8483 16 % % NN cord-010119-t1x9gknd 8483 17 ) ) -RRB- cord-010119-t1x9gknd 8483 18 were be VBD cord-010119-t1x9gknd 8483 19 critical critical JJ cord-010119-t1x9gknd 8483 20 care care NN cord-010119-t1x9gknd 8483 21 patients patient NNS cord-010119-t1x9gknd 8483 22 . . . cord-010119-t1x9gknd 8484 1 Tumor tumor NN cord-010119-t1x9gknd 8484 2 categories category NNS cord-010119-t1x9gknd 8484 3 included include VBD cord-010119-t1x9gknd 8484 4 carcinomas carcinoma NNS cord-010119-t1x9gknd 8484 5 ( ( -LRB- cord-010119-t1x9gknd 8484 6 14/30 14/30 CD cord-010119-t1x9gknd 8484 7 ) ) -RRB- cord-010119-t1x9gknd 8484 8 , , , cord-010119-t1x9gknd 8484 9 sarcomas sarcoma NNS cord-010119-t1x9gknd 8484 10 ( ( -LRB- cord-010119-t1x9gknd 8484 11 13/30 13/30 CD cord-010119-t1x9gknd 8484 12 ) ) -RRB- cord-010119-t1x9gknd 8484 13 , , , cord-010119-t1x9gknd 8484 14 leukemias leukemia NNS cord-010119-t1x9gknd 8484 15 ( ( -LRB- cord-010119-t1x9gknd 8484 16 2/30 2/30 CD cord-010119-t1x9gknd 8484 17 ) ) -RRB- cord-010119-t1x9gknd 8484 18 and and CC cord-010119-t1x9gknd 8484 19 lymphoma lymphoma NN cord-010119-t1x9gknd 8484 20 ( ( -LRB- cord-010119-t1x9gknd 8484 21 1/30 1/30 CD cord-010119-t1x9gknd 8484 22 ) ) -RRB- cord-010119-t1x9gknd 8484 23 . . . cord-010119-t1x9gknd 8485 1 Resection resection NN cord-010119-t1x9gknd 8485 2 of of IN cord-010119-t1x9gknd 8485 3 tumor tumor NN cord-010119-t1x9gknd 8485 4 followed follow VBN cord-010119-t1x9gknd 8485 5 by by IN cord-010119-t1x9gknd 8485 6 complex complex JJ cord-010119-t1x9gknd 8485 7 reconstruction reconstruction NN cord-010119-t1x9gknd 8485 8 was be VBD cord-010119-t1x9gknd 8485 9 the the DT cord-010119-t1x9gknd 8485 10 cause cause NN cord-010119-t1x9gknd 8485 11 of of IN cord-010119-t1x9gknd 8485 12 the the DT cord-010119-t1x9gknd 8485 13 majority majority NN cord-010119-t1x9gknd 8485 14 of of IN cord-010119-t1x9gknd 8485 15 MTs MTs NNP cord-010119-t1x9gknd 8485 16 . . . cord-010119-t1x9gknd 8486 1 Metastatic metastatic JJ cord-010119-t1x9gknd 8486 2 renal renal JJ cord-010119-t1x9gknd 8486 3 cancer cancer NN cord-010119-t1x9gknd 8486 4 ( ( -LRB- cord-010119-t1x9gknd 8486 5 6/30 6/30 CD cord-010119-t1x9gknd 8486 6 ) ) -RRB- cord-010119-t1x9gknd 8486 7 was be VBD cord-010119-t1x9gknd 8486 8 the the DT cord-010119-t1x9gknd 8486 9 most most RBS cord-010119-t1x9gknd 8486 10 common common JJ cord-010119-t1x9gknd 8486 11 disease disease NN cord-010119-t1x9gknd 8486 12 seen see VBN cord-010119-t1x9gknd 8486 13 followed follow VBN cord-010119-t1x9gknd 8486 14 by by IN cord-010119-t1x9gknd 8486 15 sacral sacral JJ cord-010119-t1x9gknd 8486 16 chordoma chordoma NNS cord-010119-t1x9gknd 8486 17 ( ( -LRB- cord-010119-t1x9gknd 8486 18 4/30 4/30 CD cord-010119-t1x9gknd 8486 19 ) ) -RRB- cord-010119-t1x9gknd 8486 20 . . . cord-010119-t1x9gknd 8487 1 MTPs mtp NNS cord-010119-t1x9gknd 8487 2 were be VBD cord-010119-t1x9gknd 8487 3 activated activate VBN cord-010119-t1x9gknd 8487 4 in in IN cord-010119-t1x9gknd 8487 5 only only RB cord-010119-t1x9gknd 8487 6 8/30 8/30 CD cord-010119-t1x9gknd 8487 7 ( ( -LRB- cord-010119-t1x9gknd 8487 8 26.7 26.7 CD cord-010119-t1x9gknd 8487 9 % % NN cord-010119-t1x9gknd 8487 10 ) ) -RRB- cord-010119-t1x9gknd 8487 11 cases case NNS cord-010119-t1x9gknd 8487 12 . . . cord-010119-t1x9gknd 8488 1 Thirty thirty CD cord-010119-t1x9gknd 8488 2 - - HYPH cord-010119-t1x9gknd 8488 3 day day NN cord-010119-t1x9gknd 8488 4 survival survival NN cord-010119-t1x9gknd 8488 5 was be VBD cord-010119-t1x9gknd 8488 6 seen see VBN cord-010119-t1x9gknd 8488 7 in in IN cord-010119-t1x9gknd 8488 8 25/30 25/30 CD cord-010119-t1x9gknd 8488 9 ( ( -LRB- cord-010119-t1x9gknd 8488 10 83.3 83.3 CD cord-010119-t1x9gknd 8488 11 % % NN cord-010119-t1x9gknd 8488 12 ) ) -RRB- cord-010119-t1x9gknd 8488 13 patients patient NNS cord-010119-t1x9gknd 8488 14 . . . cord-010119-t1x9gknd 8489 1 Only only RB cord-010119-t1x9gknd 8489 2 1 1 CD cord-010119-t1x9gknd 8489 3 of of IN cord-010119-t1x9gknd 8489 4 5 5 CD cord-010119-t1x9gknd 8489 5 mortalities mortality NNS cord-010119-t1x9gknd 8489 6 was be VBD cord-010119-t1x9gknd 8489 7 a a DT cord-010119-t1x9gknd 8489 8 surgical surgical JJ cord-010119-t1x9gknd 8489 9 case case NN cord-010119-t1x9gknd 8489 10 ( ( -LRB- cord-010119-t1x9gknd 8489 11 peritoneal peritoneal JJ cord-010119-t1x9gknd 8489 12 mesothelioma mesothelioma NN cord-010119-t1x9gknd 8489 13 ) ) -RRB- cord-010119-t1x9gknd 8489 14 , , , cord-010119-t1x9gknd 8489 15 and and CC cord-010119-t1x9gknd 8489 16 the the DT cord-010119-t1x9gknd 8489 17 remainder remainder NN cord-010119-t1x9gknd 8489 18 were be VBD cord-010119-t1x9gknd 8489 19 caused cause VBN cord-010119-t1x9gknd 8489 20 by by IN cord-010119-t1x9gknd 8489 21 GI GI NNP cord-010119-t1x9gknd 8489 22 hemorrhage hemorrhage NN cord-010119-t1x9gknd 8489 23 ( ( -LRB- cord-010119-t1x9gknd 8489 24 3/ 3/ CD cord-010119-t1x9gknd 8489 25 5 5 CD cord-010119-t1x9gknd 8489 26 ) ) -RRB- cord-010119-t1x9gknd 8489 27 or or CC cord-010119-t1x9gknd 8489 28 perisplenic perisplenic JJ cord-010119-t1x9gknd 8489 29 hematoma hematoma NN cord-010119-t1x9gknd 8489 30 ( ( -LRB- cord-010119-t1x9gknd 8489 31 1/5 1/5 CD cord-010119-t1x9gknd 8489 32 ) ) -RRB- cord-010119-t1x9gknd 8489 33 . . . cord-010119-t1x9gknd 8490 1 The the DT cord-010119-t1x9gknd 8490 2 overall overall JJ cord-010119-t1x9gknd 8490 3 ratio ratio NN cord-010119-t1x9gknd 8490 4 of of IN cord-010119-t1x9gknd 8490 5 RBC RBC NNP cord-010119-t1x9gknd 8490 6 : : : cord-010119-t1x9gknd 8490 7 FFP FFP NNP cord-010119-t1x9gknd 8490 8 in in IN cord-010119-t1x9gknd 8490 9 the the DT cord-010119-t1x9gknd 8490 10 entire entire JJ cord-010119-t1x9gknd 8490 11 Patients patient NNS cord-010119-t1x9gknd 8491 1 ( ( -LRB- cord-010119-t1x9gknd 8491 2 Background Background NNP cord-010119-t1x9gknd 8491 3 / / SYM cord-010119-t1x9gknd 8491 4 Case Case NNP cord-010119-t1x9gknd 8491 5 Studies Studies NNPS cord-010119-t1x9gknd 8492 1 : : : cord-010119-t1x9gknd 8492 2 Plasma plasma NN cord-010119-t1x9gknd 8492 3 is be VBZ cord-010119-t1x9gknd 8492 4 a a DT cord-010119-t1x9gknd 8492 5 straw straw NN cord-010119-t1x9gknd 8492 6 - - HYPH cord-010119-t1x9gknd 8492 7 colored colored JJ cord-010119-t1x9gknd 8492 8 supernatant supernatant NN cord-010119-t1x9gknd 8492 9 of of IN cord-010119-t1x9gknd 8492 10 blood blood NN cord-010119-t1x9gknd 8492 11 that that WDT cord-010119-t1x9gknd 8492 12 is be VBZ cord-010119-t1x9gknd 8492 13 used use VBN cord-010119-t1x9gknd 8492 14 for for IN cord-010119-t1x9gknd 8492 15 type type NN cord-010119-t1x9gknd 8492 16 and and CC cord-010119-t1x9gknd 8492 17 screen screen NN cord-010119-t1x9gknd 8492 18 ( ( -LRB- cord-010119-t1x9gknd 8492 19 T&S t&s NN cord-010119-t1x9gknd 8492 20 ) ) -RRB- cord-010119-t1x9gknd 8492 21 and and CC cord-010119-t1x9gknd 8492 22 crossmatch crossmatch NN cord-010119-t1x9gknd 8492 23 . . . cord-010119-t1x9gknd 8493 1 In in IN cord-010119-t1x9gknd 8493 2 the the DT cord-010119-t1x9gknd 8493 3 analytic analytic JJ cord-010119-t1x9gknd 8493 4 phase phase NN cord-010119-t1x9gknd 8493 5 of of IN cord-010119-t1x9gknd 8493 6 testing testing NN cord-010119-t1x9gknd 8493 7 , , , cord-010119-t1x9gknd 8493 8 plasma plasma NN cord-010119-t1x9gknd 8493 9 is be VBZ cord-010119-t1x9gknd 8493 10 examined examine VBN cord-010119-t1x9gknd 8493 11 prior prior RB cord-010119-t1x9gknd 8493 12 to to IN cord-010119-t1x9gknd 8493 13 processing processing NN cord-010119-t1x9gknd 8493 14 . . . cord-010119-t1x9gknd 8494 1 Plasma plasma NN cord-010119-t1x9gknd 8494 2 occasionally occasionally RB cord-010119-t1x9gknd 8494 3 becomes become VBZ cord-010119-t1x9gknd 8494 4 discolored discolored JJ cord-010119-t1x9gknd 8494 5 , , , cord-010119-t1x9gknd 8494 6 interfering interfere VBG cord-010119-t1x9gknd 8494 7 with with IN cord-010119-t1x9gknd 8494 8 crossmatch crossmatch NN cord-010119-t1x9gknd 8494 9 procedures procedure NNS cord-010119-t1x9gknd 8494 10 . . . cord-010119-t1x9gknd 8495 1 Timely timely JJ cord-010119-t1x9gknd 8495 2 identification identification NN cord-010119-t1x9gknd 8495 3 of of IN cord-010119-t1x9gknd 8495 4 the the DT cord-010119-t1x9gknd 8495 5 etiology etiology NN cord-010119-t1x9gknd 8495 6 allows allow VBZ cord-010119-t1x9gknd 8495 7 for for IN cord-010119-t1x9gknd 8495 8 corrective corrective JJ cord-010119-t1x9gknd 8495 9 actions action NNS cord-010119-t1x9gknd 8495 10 and and CC cord-010119-t1x9gknd 8495 11 minimizes minimize VBZ cord-010119-t1x9gknd 8495 12 delay delay NN cord-010119-t1x9gknd 8495 13 in in IN cord-010119-t1x9gknd 8495 14 transfusion transfusion NN cord-010119-t1x9gknd 8495 15 . . . cord-010119-t1x9gknd 8496 1 Study Study NNP cord-010119-t1x9gknd 8496 2 Design Design NNP cord-010119-t1x9gknd 8496 3 / / SYM cord-010119-t1x9gknd 8496 4 Method method NN cord-010119-t1x9gknd 8496 5 : : : cord-010119-t1x9gknd 8496 6 During during IN cord-010119-t1x9gknd 8496 7 the the DT cord-010119-t1x9gknd 8496 8 analytic analytic JJ cord-010119-t1x9gknd 8496 9 phase phase NN cord-010119-t1x9gknd 8496 10 of of IN cord-010119-t1x9gknd 8496 11 blood blood NN cord-010119-t1x9gknd 8496 12 bank bank NN cord-010119-t1x9gknd 8496 13 testing testing NN cord-010119-t1x9gknd 8496 14 , , , cord-010119-t1x9gknd 8496 15 samples sample NNS cord-010119-t1x9gknd 8496 16 were be VBD cord-010119-t1x9gknd 8496 17 evaluated evaluate VBN cord-010119-t1x9gknd 8496 18 for for IN cord-010119-t1x9gknd 8496 19 T&S t&s NN cord-010119-t1x9gknd 8496 20 and and CC cord-010119-t1x9gknd 8496 21 crossmatch crossmatch NN cord-010119-t1x9gknd 8496 22 ; ; : cord-010119-t1x9gknd 8496 23 this this DT cord-010119-t1x9gknd 8496 24 identified identify VBD cord-010119-t1x9gknd 8496 25 three three CD cord-010119-t1x9gknd 8496 26 samples sample NNS cord-010119-t1x9gknd 8496 27 with with IN cord-010119-t1x9gknd 8496 28 discolored discolored JJ cord-010119-t1x9gknd 8496 29 plasma plasma NN cord-010119-t1x9gknd 8496 30 . . . cord-010119-t1x9gknd 8497 1 We -PRON- PRP cord-010119-t1x9gknd 8497 2 present present VBP cord-010119-t1x9gknd 8497 3 a a DT cord-010119-t1x9gknd 8497 4 series series NN cord-010119-t1x9gknd 8497 5 of of IN cord-010119-t1x9gknd 8497 6 cases case NNS cord-010119-t1x9gknd 8497 7 that that WDT cord-010119-t1x9gknd 8497 8 illustrate illustrate VBP cord-010119-t1x9gknd 8497 9 the the DT cord-010119-t1x9gknd 8497 10 testing testing NN cord-010119-t1x9gknd 8497 11 process process NN cord-010119-t1x9gknd 8497 12 . . . cord-010119-t1x9gknd 8498 1 Results/ Results/ . cord-010119-t1x9gknd 8499 1 Finding finding NN cord-010119-t1x9gknd 8499 2 : : : cord-010119-t1x9gknd 8500 1 A a DT cord-010119-t1x9gknd 8500 2 54-year 54-year JJ cord-010119-t1x9gknd 8500 3 - - HYPH cord-010119-t1x9gknd 8500 4 old old JJ cord-010119-t1x9gknd 8500 5 woman woman NN cord-010119-t1x9gknd 8500 6 diagnosed diagnose VBN cord-010119-t1x9gknd 8500 7 with with IN cord-010119-t1x9gknd 8500 8 breast breast NN cord-010119-t1x9gknd 8500 9 cancer cancer NN cord-010119-t1x9gknd 8500 10 presented present VBN cord-010119-t1x9gknd 8500 11 for for IN cord-010119-t1x9gknd 8500 12 mastectomy mastectomy NN cord-010119-t1x9gknd 8500 13 with with IN cord-010119-t1x9gknd 8500 14 sentinel sentinel JJ cord-010119-t1x9gknd 8500 15 lymph lymph NN cord-010119-t1x9gknd 8500 16 node node NN cord-010119-t1x9gknd 8500 17 biopsy biopsy NN cord-010119-t1x9gknd 8500 18 . . . cord-010119-t1x9gknd 8501 1 A a DT cord-010119-t1x9gknd 8501 2 preoperative preoperative JJ cord-010119-t1x9gknd 8501 3 T&S t&s NN cord-010119-t1x9gknd 8501 4 specimen specimen NN cord-010119-t1x9gknd 8501 5 contained contain VBD cord-010119-t1x9gknd 8501 6 bright bright JJ cord-010119-t1x9gknd 8501 7 green green JJ cord-010119-t1x9gknd 8501 8 plasma plasma NN cord-010119-t1x9gknd 8501 9 . . . cord-010119-t1x9gknd 8502 1 Review Review NNP cord-010119-t1x9gknd 8502 2 of of IN cord-010119-t1x9gknd 8502 3 her -PRON- PRP$ cord-010119-t1x9gknd 8502 4 preoperative preoperative JJ cord-010119-t1x9gknd 8502 5 case case NN cord-010119-t1x9gknd 8502 6 revealed reveal VBD cord-010119-t1x9gknd 8502 7 exposure exposure NN cord-010119-t1x9gknd 8502 8 to to IN cord-010119-t1x9gknd 8502 9 intravenous intravenous JJ cord-010119-t1x9gknd 8502 10 methylene methylene NN cord-010119-t1x9gknd 8502 11 blue blue NN cord-010119-t1x9gknd 8502 12 . . . cord-010119-t1x9gknd 8503 1 This this DT cord-010119-t1x9gknd 8503 2 dye dye NN cord-010119-t1x9gknd 8503 3 is be VBZ cord-010119-t1x9gknd 8503 4 known know VBN cord-010119-t1x9gknd 8503 5 to to TO cord-010119-t1x9gknd 8503 6 alter alter VB cord-010119-t1x9gknd 8503 7 the the DT cord-010119-t1x9gknd 8503 8 color color NN cord-010119-t1x9gknd 8503 9 of of IN cord-010119-t1x9gknd 8503 10 urine urine NN cord-010119-t1x9gknd 8503 11 , , , cord-010119-t1x9gknd 8503 12 tears tear NNS cord-010119-t1x9gknd 8503 13 , , , cord-010119-t1x9gknd 8503 14 and and CC cord-010119-t1x9gknd 8503 15 blood blood NN cord-010119-t1x9gknd 8503 16 with with IN cord-010119-t1x9gknd 8503 17 no no DT cord-010119-t1x9gknd 8503 18 known know VBN cord-010119-t1x9gknd 8503 19 pharmacologic pharmacologic JJ cord-010119-t1x9gknd 8503 20 effects effect NNS cord-010119-t1x9gknd 8503 21 . . . cord-010119-t1x9gknd 8504 1 Alternative alternative JJ cord-010119-t1x9gknd 8504 2 causes cause NNS cord-010119-t1x9gknd 8504 3 of of IN cord-010119-t1x9gknd 8504 4 green green JJ cord-010119-t1x9gknd 8504 5 plasma plasma NN cord-010119-t1x9gknd 8504 6 include include VBP cord-010119-t1x9gknd 8504 7 other other JJ cord-010119-t1x9gknd 8504 8 dyes dye NNS cord-010119-t1x9gknd 8504 9 used use VBN cord-010119-t1x9gknd 8504 10 to to TO cord-010119-t1x9gknd 8504 11 locate locate VB cord-010119-t1x9gknd 8504 12 sentinel sentinel JJ cord-010119-t1x9gknd 8504 13 nodes node NNS cord-010119-t1x9gknd 8504 14 and and CC cord-010119-t1x9gknd 8504 15 oral oral JJ cord-010119-t1x9gknd 8504 16 contraceptive contraceptive JJ cord-010119-t1x9gknd 8504 17 use use NN cord-010119-t1x9gknd 8504 18 . . . cord-010119-t1x9gknd 8505 1 Although although IN cord-010119-t1x9gknd 8505 2 not not RB cord-010119-t1x9gknd 8505 3 ideal ideal JJ cord-010119-t1x9gknd 8505 4 , , , cord-010119-t1x9gknd 8505 5 this this DT cord-010119-t1x9gknd 8505 6 sample sample NN cord-010119-t1x9gknd 8505 7 could could MD cord-010119-t1x9gknd 8505 8 be be VB cord-010119-t1x9gknd 8505 9 used use VBN cord-010119-t1x9gknd 8505 10 for for IN cord-010119-t1x9gknd 8505 11 crossmatch crossmatch NN cord-010119-t1x9gknd 8505 12 by by IN cord-010119-t1x9gknd 8505 13 tube tube NN cord-010119-t1x9gknd 8505 14 method method NN cord-010119-t1x9gknd 8505 15 , , , cord-010119-t1x9gknd 8505 16 but but CC cord-010119-t1x9gknd 8505 17 not not RB cord-010119-t1x9gknd 8505 18 automated automate VBN cord-010119-t1x9gknd 8505 19 gel gel NN cord-010119-t1x9gknd 8505 20 technique technique NN cord-010119-t1x9gknd 8505 21 . . . cord-010119-t1x9gknd 8506 1 A a DT cord-010119-t1x9gknd 8506 2 specimen specimen NN cord-010119-t1x9gknd 8506 3 drawn draw VBN cord-010119-t1x9gknd 8506 4 one one CD cord-010119-t1x9gknd 8506 5 week week NN cord-010119-t1x9gknd 8506 6 later later RB cord-010119-t1x9gknd 8506 7 contained contain VBD cord-010119-t1x9gknd 8506 8 clear clear JJ cord-010119-t1x9gknd 8506 9 plasma plasma NN cord-010119-t1x9gknd 8506 10 . . . cord-010119-t1x9gknd 8507 1 A a DT cord-010119-t1x9gknd 8507 2 26-year 26-year JJ cord-010119-t1x9gknd 8507 3 - - HYPH cord-010119-t1x9gknd 8507 4 old old JJ cord-010119-t1x9gknd 8507 5 woman woman NN cord-010119-t1x9gknd 8507 6 diagnosed diagnose VBN cord-010119-t1x9gknd 8507 7 with with IN cord-010119-t1x9gknd 8507 8 a a DT cord-010119-t1x9gknd 8507 9 warm warm JJ cord-010119-t1x9gknd 8507 10 autoimmune autoimmune JJ cord-010119-t1x9gknd 8507 11 hemolytic hemolytic JJ cord-010119-t1x9gknd 8507 12 anemia anemia NN cord-010119-t1x9gknd 8507 13 was be VBD cord-010119-t1x9gknd 8507 14 refractory refractory JJ cord-010119-t1x9gknd 8507 15 to to IN cord-010119-t1x9gknd 8507 16 blood blood NN cord-010119-t1x9gknd 8507 17 transfusions transfusion NNS cord-010119-t1x9gknd 8507 18 secondary secondary JJ cord-010119-t1x9gknd 8507 19 to to IN cord-010119-t1x9gknd 8507 20 alloantibodies alloantibody NNS cord-010119-t1x9gknd 8507 21 . . . cord-010119-t1x9gknd 8508 1 Administration administration NN cord-010119-t1x9gknd 8508 2 of of IN cord-010119-t1x9gknd 8508 3 a a DT cord-010119-t1x9gknd 8508 4 synthetic synthetic JJ cord-010119-t1x9gknd 8508 5 blood blood NN cord-010119-t1x9gknd 8508 6 product product NN cord-010119-t1x9gknd 8508 7 resulted result VBD cord-010119-t1x9gknd 8508 8 in in IN cord-010119-t1x9gknd 8508 9 dark dark JJ cord-010119-t1x9gknd 8508 10 maroon maroon JJ cord-010119-t1x9gknd 8508 11 colored colored JJ cord-010119-t1x9gknd 8508 12 plasma plasma NN cord-010119-t1x9gknd 8508 13 . . . cord-010119-t1x9gknd 8509 1 The the DT cord-010119-t1x9gknd 8509 2 most most RBS cord-010119-t1x9gknd 8509 3 common common JJ cord-010119-t1x9gknd 8509 4 cause cause NN cord-010119-t1x9gknd 8509 5 of of IN cord-010119-t1x9gknd 8509 6 a a DT cord-010119-t1x9gknd 8509 7 dark dark JJ cord-010119-t1x9gknd 8509 8 red red JJ cord-010119-t1x9gknd 8509 9 color color NN cord-010119-t1x9gknd 8509 10 is be VBZ cord-010119-t1x9gknd 8509 11 hemolysis hemolysis NN cord-010119-t1x9gknd 8509 12 of of IN cord-010119-t1x9gknd 8509 13 the the DT cord-010119-t1x9gknd 8509 14 sample sample NN cord-010119-t1x9gknd 8509 15 , , , cord-010119-t1x9gknd 8509 16 which which WDT cord-010119-t1x9gknd 8509 17 is be VBZ cord-010119-t1x9gknd 8509 18 usually usually RB cord-010119-t1x9gknd 8509 19 discarded discard VBN cord-010119-t1x9gknd 8509 20 . . . cord-010119-t1x9gknd 8510 1 In in IN cord-010119-t1x9gknd 8510 2 this this DT cord-010119-t1x9gknd 8510 3 instance instance NN cord-010119-t1x9gknd 8510 4 , , , cord-010119-t1x9gknd 8510 5 the the DT cord-010119-t1x9gknd 8510 6 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8510 7 color color NN cord-010119-t1x9gknd 8510 8 was be VBD cord-010119-t1x9gknd 8510 9 due due JJ cord-010119-t1x9gknd 8510 10 to to IN cord-010119-t1x9gknd 8510 11 the the DT cord-010119-t1x9gknd 8510 12 infused infuse VBN cord-010119-t1x9gknd 8510 13 product product NN cord-010119-t1x9gknd 8510 14 , , , cord-010119-t1x9gknd 8510 15 an an DT cord-010119-t1x9gknd 8510 16 experimental experimental JJ cord-010119-t1x9gknd 8510 17 bovine bovine NN cord-010119-t1x9gknd 8510 18 pegylated pegylated JJ cord-010119-t1x9gknd 8510 19 carboxyhemoglobin carboxyhemoglobin NNP cord-010119-t1x9gknd 8510 20 that that WDT cord-010119-t1x9gknd 8510 21 affects affect VBZ cord-010119-t1x9gknd 8510 22 colorimetric colorimetric JJ cord-010119-t1x9gknd 8510 23 evaluation evaluation NN cord-010119-t1x9gknd 8510 24 of of IN cord-010119-t1x9gknd 8510 25 blood blood NN cord-010119-t1x9gknd 8510 26 samples sample NNS cord-010119-t1x9gknd 8510 27 . . . cord-010119-t1x9gknd 8511 1 With with IN cord-010119-t1x9gknd 8511 2 this this DT cord-010119-t1x9gknd 8511 3 in in IN cord-010119-t1x9gknd 8511 4 mind mind NN cord-010119-t1x9gknd 8511 5 , , , cord-010119-t1x9gknd 8511 6 the the DT cord-010119-t1x9gknd 8511 7 sample sample NN cord-010119-t1x9gknd 8511 8 was be VBD cord-010119-t1x9gknd 8511 9 not not RB cord-010119-t1x9gknd 8511 10 discarded discard VBN cord-010119-t1x9gknd 8511 11 and and CC cord-010119-t1x9gknd 8511 12 testing testing NN cord-010119-t1x9gknd 8511 13 was be VBD cord-010119-t1x9gknd 8511 14 completed complete VBN cord-010119-t1x9gknd 8511 15 by by IN cord-010119-t1x9gknd 8511 16 tube tube NN cord-010119-t1x9gknd 8511 17 method method NN cord-010119-t1x9gknd 8511 18 . . . cord-010119-t1x9gknd 8512 1 A a DT cord-010119-t1x9gknd 8512 2 70-year 70-year JJ cord-010119-t1x9gknd 8512 3 - - HYPH cord-010119-t1x9gknd 8512 4 old old JJ cord-010119-t1x9gknd 8512 5 woman woman NN cord-010119-t1x9gknd 8512 6 admitted admit VBN cord-010119-t1x9gknd 8512 7 with with IN cord-010119-t1x9gknd 8512 8 acute acute JJ cord-010119-t1x9gknd 8512 9 stroke stroke NN cord-010119-t1x9gknd 8512 10 was be VBD cord-010119-t1x9gknd 8512 11 treated treat VBN cord-010119-t1x9gknd 8512 12 with with IN cord-010119-t1x9gknd 8512 13 a a DT cord-010119-t1x9gknd 8512 14 thrombolytic thrombolytic NN cord-010119-t1x9gknd 8512 15 . . . cord-010119-t1x9gknd 8513 1 Her -PRON- PRP$ cord-010119-t1x9gknd 8513 2 T&S t&s NN cord-010119-t1x9gknd 8513 3 revealed reveal VBD cord-010119-t1x9gknd 8513 4 cloudy cloudy JJ cord-010119-t1x9gknd 8513 5 white white JJ cord-010119-t1x9gknd 8513 6 plasma plasma NN cord-010119-t1x9gknd 8513 7 that that WDT cord-010119-t1x9gknd 8513 8 could could MD cord-010119-t1x9gknd 8513 9 not not RB cord-010119-t1x9gknd 8513 10 be be VB cord-010119-t1x9gknd 8513 11 used use VBN cord-010119-t1x9gknd 8513 12 for for IN cord-010119-t1x9gknd 8513 13 the the DT cord-010119-t1x9gknd 8513 14 crossmatch crossmatch NN cord-010119-t1x9gknd 8513 15 procedure procedure NN cord-010119-t1x9gknd 8513 16 . . . cord-010119-t1x9gknd 8514 1 Common common JJ cord-010119-t1x9gknd 8514 2 causes cause NNS cord-010119-t1x9gknd 8514 3 of of IN cord-010119-t1x9gknd 8514 4 white white JJ cord-010119-t1x9gknd 8514 5 plasma plasma NN cord-010119-t1x9gknd 8514 6 include include VBP cord-010119-t1x9gknd 8514 7 purulence purulence NNP cord-010119-t1x9gknd 8514 8 , , , cord-010119-t1x9gknd 8514 9 hypertriglyceridemia hypertriglyceridemia NN cord-010119-t1x9gknd 8514 10 , , , cord-010119-t1x9gknd 8514 11 and and CC cord-010119-t1x9gknd 8514 12 sampling sampling NN cord-010119-t1x9gknd 8514 13 of of IN cord-010119-t1x9gknd 8514 14 blood blood NN cord-010119-t1x9gknd 8514 15 drawn draw VBN cord-010119-t1x9gknd 8514 16 proximal proximal JJ cord-010119-t1x9gknd 8514 17 to to IN cord-010119-t1x9gknd 8514 18 administration administration NN cord-010119-t1x9gknd 8514 19 of of IN cord-010119-t1x9gknd 8514 20 radiopaque radiopaque NNP cord-010119-t1x9gknd 8514 21 agents agent NNS cord-010119-t1x9gknd 8514 22 such such JJ cord-010119-t1x9gknd 8514 23 as as IN cord-010119-t1x9gknd 8514 24 propofol propofol NN cord-010119-t1x9gknd 8514 25 . . . cord-010119-t1x9gknd 8515 1 Although although IN cord-010119-t1x9gknd 8515 2 an an DT cord-010119-t1x9gknd 8515 3 etiology etiology NN cord-010119-t1x9gknd 8515 4 could could MD cord-010119-t1x9gknd 8515 5 not not RB cord-010119-t1x9gknd 8515 6 be be VB cord-010119-t1x9gknd 8515 7 identified identify VBN cord-010119-t1x9gknd 8515 8 a a DT cord-010119-t1x9gknd 8515 9 repeat repeat NN cord-010119-t1x9gknd 8515 10 specimen specimen NN cord-010119-t1x9gknd 8515 11 drawn draw VBN cord-010119-t1x9gknd 8515 12 several several JJ cord-010119-t1x9gknd 8515 13 hours hour NNS cord-010119-t1x9gknd 8515 14 later later RB cord-010119-t1x9gknd 8515 15 was be VBD cord-010119-t1x9gknd 8515 16 clear clear JJ cord-010119-t1x9gknd 8515 17 . . . cord-010119-t1x9gknd 8516 1 Conclusion conclusion NN cord-010119-t1x9gknd 8516 2 : : : cord-010119-t1x9gknd 8517 1 These these DT cord-010119-t1x9gknd 8517 2 cases case NNS cord-010119-t1x9gknd 8517 3 highlight highlight VBP cord-010119-t1x9gknd 8517 4 the the DT cord-010119-t1x9gknd 8517 5 importance importance NN cord-010119-t1x9gknd 8517 6 of of IN cord-010119-t1x9gknd 8517 7 an an DT cord-010119-t1x9gknd 8517 8 appropriate appropriate JJ cord-010119-t1x9gknd 8517 9 evaluation evaluation NN cord-010119-t1x9gknd 8517 10 of of IN cord-010119-t1x9gknd 8517 11 discolored discolored JJ cord-010119-t1x9gknd 8517 12 plasma plasma NN cord-010119-t1x9gknd 8517 13 . . . cord-010119-t1x9gknd 8518 1 Once once RB cord-010119-t1x9gknd 8518 2 a a DT cord-010119-t1x9gknd 8518 3 discolored discolored JJ cord-010119-t1x9gknd 8518 4 sample sample NN cord-010119-t1x9gknd 8518 5 is be VBZ cord-010119-t1x9gknd 8518 6 identified identify VBN cord-010119-t1x9gknd 8518 7 , , , cord-010119-t1x9gknd 8518 8 a a DT cord-010119-t1x9gknd 8518 9 repeat repeat NN cord-010119-t1x9gknd 8518 10 sample sample NN cord-010119-t1x9gknd 8518 11 is be VBZ cord-010119-t1x9gknd 8518 12 required require VBN cord-010119-t1x9gknd 8518 13 to to TO cord-010119-t1x9gknd 8518 14 confirm confirm VB cord-010119-t1x9gknd 8518 15 the the DT cord-010119-t1x9gknd 8518 16 change change NN cord-010119-t1x9gknd 8518 17 in in IN cord-010119-t1x9gknd 8518 18 color color NN cord-010119-t1x9gknd 8518 19 . . . cord-010119-t1x9gknd 8519 1 In in IN cord-010119-t1x9gknd 8519 2 the the DT cord-010119-t1x9gknd 8519 3 first first JJ cord-010119-t1x9gknd 8519 4 two two CD cord-010119-t1x9gknd 8519 5 cases case NNS cord-010119-t1x9gknd 8519 6 , , , cord-010119-t1x9gknd 8519 7 the the DT cord-010119-t1x9gknd 8519 8 discoloration discoloration NN cord-010119-t1x9gknd 8519 9 persisted persist VBD cord-010119-t1x9gknd 8519 10 , , , cord-010119-t1x9gknd 8519 11 prompting prompt VBG cord-010119-t1x9gknd 8519 12 further further JJ cord-010119-t1x9gknd 8519 13 clinical clinical JJ cord-010119-t1x9gknd 8519 14 investigation investigation NN cord-010119-t1x9gknd 8519 15 . . . cord-010119-t1x9gknd 8520 1 Once once IN cord-010119-t1x9gknd 8520 2 the the DT cord-010119-t1x9gknd 8520 3 etiology etiology NN cord-010119-t1x9gknd 8520 4 was be VBD cord-010119-t1x9gknd 8520 5 identified identify VBN cord-010119-t1x9gknd 8520 6 , , , cord-010119-t1x9gknd 8520 7 need need VBP cord-010119-t1x9gknd 8520 8 for for IN cord-010119-t1x9gknd 8520 9 further further JJ cord-010119-t1x9gknd 8520 10 testing testing NN cord-010119-t1x9gknd 8520 11 and and CC cord-010119-t1x9gknd 8520 12 eligibility eligibility NN cord-010119-t1x9gknd 8520 13 for for IN cord-010119-t1x9gknd 8520 14 further further JJ cord-010119-t1x9gknd 8520 15 transfusion transfusion NN cord-010119-t1x9gknd 8520 16 was be VBD cord-010119-t1x9gknd 8520 17 determined determine VBN cord-010119-t1x9gknd 8520 18 . . . cord-010119-t1x9gknd 8521 1 Testing testing NN cord-010119-t1x9gknd 8521 2 by by IN cord-010119-t1x9gknd 8521 3 tube tube NN cord-010119-t1x9gknd 8521 4 method method NN cord-010119-t1x9gknd 8521 5 could could MD cord-010119-t1x9gknd 8521 6 be be VB cord-010119-t1x9gknd 8521 7 performed perform VBN cord-010119-t1x9gknd 8521 8 in in IN cord-010119-t1x9gknd 8521 9 two two CD cord-010119-t1x9gknd 8521 10 cases case NNS cord-010119-t1x9gknd 8521 11 . . . cord-010119-t1x9gknd 8522 1 In in IN cord-010119-t1x9gknd 8522 2 the the DT cord-010119-t1x9gknd 8522 3 third third JJ cord-010119-t1x9gknd 8522 4 case case NN cord-010119-t1x9gknd 8522 5 , , , cord-010119-t1x9gknd 8522 6 repeated repeat VBN cord-010119-t1x9gknd 8522 7 sampling sampling NN cord-010119-t1x9gknd 8522 8 revealed reveal VBD cord-010119-t1x9gknd 8522 9 a a DT cord-010119-t1x9gknd 8522 10 clear clear JJ cord-010119-t1x9gknd 8522 11 sample sample NN cord-010119-t1x9gknd 8522 12 and and CC cord-010119-t1x9gknd 8522 13 the the DT cord-010119-t1x9gknd 8522 14 transfusion transfusion NN cord-010119-t1x9gknd 8522 15 process process NN cord-010119-t1x9gknd 8522 16 continued continue VBD cord-010119-t1x9gknd 8522 17 without without IN cord-010119-t1x9gknd 8522 18 delay delay NN cord-010119-t1x9gknd 8522 19 . . . cord-010119-t1x9gknd 8523 1 Decisions decision NNS cord-010119-t1x9gknd 8523 2 regarding regard VBG cord-010119-t1x9gknd 8523 3 the the DT cord-010119-t1x9gknd 8523 4 analytic analytic JJ cord-010119-t1x9gknd 8523 5 phase phase NN cord-010119-t1x9gknd 8523 6 of of IN cord-010119-t1x9gknd 8523 7 testing testing NN cord-010119-t1x9gknd 8523 8 must must MD cord-010119-t1x9gknd 8523 9 include include VB cord-010119-t1x9gknd 8523 10 reevaluation reevaluation NN cord-010119-t1x9gknd 8523 11 of of IN cord-010119-t1x9gknd 8523 12 the the DT cord-010119-t1x9gknd 8523 13 sample sample NN cord-010119-t1x9gknd 8523 14 , , , cord-010119-t1x9gknd 8523 15 identification identification NN cord-010119-t1x9gknd 8523 16 of of IN cord-010119-t1x9gknd 8523 17 the the DT cord-010119-t1x9gknd 8523 18 etiology etiology NN cord-010119-t1x9gknd 8523 19 , , , cord-010119-t1x9gknd 8523 20 and and CC cord-010119-t1x9gknd 8523 21 comprehension comprehension NN cord-010119-t1x9gknd 8523 22 regarding regard VBG cord-010119-t1x9gknd 8523 23 how how WRB cord-010119-t1x9gknd 8523 24 to to TO cord-010119-t1x9gknd 8523 25 proceed proceed VB cord-010119-t1x9gknd 8523 26 when when WRB cord-010119-t1x9gknd 8523 27 discoloration discoloration NN cord-010119-t1x9gknd 8523 28 persists persist VBZ cord-010119-t1x9gknd 8523 29 . . . cord-010119-t1x9gknd 8524 1 Caleb Caleb NNP cord-010119-t1x9gknd 8524 2 Wei Wei NNP cord-010119-t1x9gknd 8524 3 - - HYPH cord-010119-t1x9gknd 8524 4 Shin Shin NNP cord-010119-t1x9gknd 8524 5 Cheng Cheng NNP cord-010119-t1x9gknd 8524 6 * * NFP cord-010119-t1x9gknd 8524 7 1,2 1,2 CD cord-010119-t1x9gknd 8524 8 , , , cord-010119-t1x9gknd 8524 9 Rebecca Rebecca NNP cord-010119-t1x9gknd 8524 10 Ross Ross NNP cord-010119-t1x9gknd 8524 11 2 2 CD cord-010119-t1x9gknd 8524 12 , , , cord-010119-t1x9gknd 8524 13 Christopher Christopher NNP cord-010119-t1x9gknd 8524 14 A A NNP cord-010119-t1x9gknd 8524 15 Tormey Tormey NNP cord-010119-t1x9gknd 8524 16 1,2,3 1,2,3 CD cord-010119-t1x9gknd 8524 17 and and CC cord-010119-t1x9gknd 8524 18 Amit Amit NNP cord-010119-t1x9gknd 8524 19 Gokhale Gokhale NNP cord-010119-t1x9gknd 8524 20 1,2 1,2 CD cord-010119-t1x9gknd 8524 21 . . . cord-010119-t1x9gknd 8525 1 1 1 CD cord-010119-t1x9gknd 8525 2 Yale Yale NNP cord-010119-t1x9gknd 8525 3 University University NNP cord-010119-t1x9gknd 8525 4 School School NNP cord-010119-t1x9gknd 8525 5 of of IN cord-010119-t1x9gknd 8525 6 Medicine Medicine NNP cord-010119-t1x9gknd 8525 7 , , , cord-010119-t1x9gknd 8525 8 2 2 CD cord-010119-t1x9gknd 8525 9 Yale Yale NNP cord-010119-t1x9gknd 8525 10 - - HYPH cord-010119-t1x9gknd 8525 11 New New NNP cord-010119-t1x9gknd 8525 12 Haven Haven NNP cord-010119-t1x9gknd 8525 13 Hospital Hospital NNP cord-010119-t1x9gknd 8525 14 , , , cord-010119-t1x9gknd 8525 15 3 3 CD cord-010119-t1x9gknd 8525 16 VA VA NNP cord-010119-t1x9gknd 8525 17 Connecticut Connecticut NNP cord-010119-t1x9gknd 8525 18 Healthcare Healthcare NNP cord-010119-t1x9gknd 8525 19 Background Background NNP cord-010119-t1x9gknd 8525 20 / / SYM cord-010119-t1x9gknd 8525 21 Case Case NNP cord-010119-t1x9gknd 8525 22 Studies Studies NNPS cord-010119-t1x9gknd 8525 23 : : : cord-010119-t1x9gknd 8525 24 Daratumumab Daratumumab NNP cord-010119-t1x9gknd 8525 25 ( ( -LRB- cord-010119-t1x9gknd 8525 26 Dara Dara NNP cord-010119-t1x9gknd 8525 27 ) ) -RRB- cord-010119-t1x9gknd 8525 28 is be VBZ cord-010119-t1x9gknd 8525 29 a a DT cord-010119-t1x9gknd 8525 30 IgG1 IgG1 NNP cord-010119-t1x9gknd 8525 31 monoclonal monoclonal JJ cord-010119-t1x9gknd 8525 32 antibody antibody NN cord-010119-t1x9gknd 8525 33 therapy therapy NN cord-010119-t1x9gknd 8525 34 that that WDT cord-010119-t1x9gknd 8525 35 specifically specifically RB cord-010119-t1x9gknd 8525 36 targets target VBZ cord-010119-t1x9gknd 8525 37 CD38 CD38 NNP cord-010119-t1x9gknd 8525 38 , , , cord-010119-t1x9gknd 8525 39 a a DT cord-010119-t1x9gknd 8525 40 glycoprotein glycoprotein NN cord-010119-t1x9gknd 8525 41 highly highly RB cord-010119-t1x9gknd 8525 42 expressed express VBN cord-010119-t1x9gknd 8525 43 on on IN cord-010119-t1x9gknd 8525 44 plasma plasma NN cord-010119-t1x9gknd 8525 45 cells cell NNS cord-010119-t1x9gknd 8525 46 , , , cord-010119-t1x9gknd 8525 47 where where WRB cord-010119-t1x9gknd 8525 48 it -PRON- PRP cord-010119-t1x9gknd 8525 49 has have VBZ cord-010119-t1x9gknd 8525 50 been be VBN cord-010119-t1x9gknd 8525 51 successfully successfully RB cord-010119-t1x9gknd 8525 52 used use VBN cord-010119-t1x9gknd 8525 53 in in IN cord-010119-t1x9gknd 8525 54 patients patient NNS cord-010119-t1x9gknd 8525 55 with with IN cord-010119-t1x9gknd 8525 56 refractory refractory JJ cord-010119-t1x9gknd 8525 57 or or CC cord-010119-t1x9gknd 8525 58 relapsed relapse VBN cord-010119-t1x9gknd 8525 59 multiple multiple JJ cord-010119-t1x9gknd 8525 60 myeloma myeloma NN cord-010119-t1x9gknd 8525 61 . . . cord-010119-t1x9gknd 8526 1 Dara Dara NNP cord-010119-t1x9gknd 8526 2 interferes interfere VBZ cord-010119-t1x9gknd 8526 3 with with IN cord-010119-t1x9gknd 8526 4 blood blood NN cord-010119-t1x9gknd 8526 5 bank bank NN cord-010119-t1x9gknd 8526 6 testing testing NN cord-010119-t1x9gknd 8526 7 as as IN cord-010119-t1x9gknd 8526 8 it -PRON- PRP cord-010119-t1x9gknd 8526 9 binds bind VBZ cord-010119-t1x9gknd 8526 10 to to IN cord-010119-t1x9gknd 8526 11 CD38 CD38 NNP cord-010119-t1x9gknd 8526 12 expressed express VBD cord-010119-t1x9gknd 8526 13 on on IN cord-010119-t1x9gknd 8526 14 red red JJ cord-010119-t1x9gknd 8526 15 blood blood NN cord-010119-t1x9gknd 8526 16 cells cell NNS cord-010119-t1x9gknd 8526 17 , , , cord-010119-t1x9gknd 8526 18 causing cause VBG cord-010119-t1x9gknd 8526 19 pan pan NN cord-010119-t1x9gknd 8526 20 reactivity reactivity NN cord-010119-t1x9gknd 8526 21 . . . cord-010119-t1x9gknd 8527 1 The the DT cord-010119-t1x9gknd 8527 2 Dara Dara NNP cord-010119-t1x9gknd 8527 3 interference interference NN cord-010119-t1x9gknd 8527 4 can can MD cord-010119-t1x9gknd 8527 5 be be VB cord-010119-t1x9gknd 8527 6 overcome overcome VBN cord-010119-t1x9gknd 8527 7 with with IN cord-010119-t1x9gknd 8527 8 the the DT cord-010119-t1x9gknd 8527 9 use use NN cord-010119-t1x9gknd 8527 10 of of IN cord-010119-t1x9gknd 8527 11 dithiothreitol dithiothreitol NNP cord-010119-t1x9gknd 8527 12 ( ( -LRB- cord-010119-t1x9gknd 8527 13 DTT DTT NNP cord-010119-t1x9gknd 8527 14 ) ) -RRB- cord-010119-t1x9gknd 8527 15 treated treat VBD cord-010119-t1x9gknd 8527 16 reagent reagent JJ cord-010119-t1x9gknd 8527 17 red red JJ cord-010119-t1x9gknd 8527 18 blood blood NN cord-010119-t1x9gknd 8527 19 cells cell NNS cord-010119-t1x9gknd 8527 20 . . . cord-010119-t1x9gknd 8528 1 To to TO cord-010119-t1x9gknd 8528 2 minimize minimize VB cord-010119-t1x9gknd 8528 3 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8528 4 and and CC cord-010119-t1x9gknd 8528 5 to to TO cord-010119-t1x9gknd 8528 6 provide provide VB cord-010119-t1x9gknd 8528 7 crossmatch crossmatch NN cord-010119-t1x9gknd 8528 8 compatible compatible JJ cord-010119-t1x9gknd 8528 9 blood blood NN cord-010119-t1x9gknd 8528 10 to to IN cord-010119-t1x9gknd 8528 11 treated treat VBN cord-010119-t1x9gknd 8528 12 patients patient NNS cord-010119-t1x9gknd 8528 13 , , , cord-010119-t1x9gknd 8528 14 we -PRON- PRP cord-010119-t1x9gknd 8528 15 instituted institute VBD cord-010119-t1x9gknd 8528 16 a a DT cord-010119-t1x9gknd 8528 17 Dara Dara NNP cord-010119-t1x9gknd 8528 18 protocol protocol NN cord-010119-t1x9gknd 8528 19 in in IN cord-010119-t1x9gknd 8528 20 our -PRON- PRP$ cord-010119-t1x9gknd 8528 21 blood blood NN cord-010119-t1x9gknd 8528 22 bank bank NN cord-010119-t1x9gknd 8528 23 . . . cord-010119-t1x9gknd 8529 1 The the DT cord-010119-t1x9gknd 8529 2 purpose purpose NN cord-010119-t1x9gknd 8529 3 of of IN cord-010119-t1x9gknd 8529 4 this this DT cord-010119-t1x9gknd 8529 5 retrospective retrospective JJ cord-010119-t1x9gknd 8529 6 study study NN cord-010119-t1x9gknd 8529 7 was be VBD cord-010119-t1x9gknd 8529 8 to to TO cord-010119-t1x9gknd 8529 9 identify identify VB cord-010119-t1x9gknd 8529 10 the the DT cord-010119-t1x9gknd 8529 11 outcomes outcome NNS cord-010119-t1x9gknd 8529 12 of of IN cord-010119-t1x9gknd 8529 13 our -PRON- PRP$ cord-010119-t1x9gknd 8529 14 protocol protocol NN cord-010119-t1x9gknd 8529 15 , , , cord-010119-t1x9gknd 8529 16 with with IN cord-010119-t1x9gknd 8529 17 a a DT cord-010119-t1x9gknd 8529 18 particular particular JJ cord-010119-t1x9gknd 8529 19 focus focus NN cord-010119-t1x9gknd 8529 20 on on IN cord-010119-t1x9gknd 8529 21 the the DT cord-010119-t1x9gknd 8529 22 development development NN cord-010119-t1x9gknd 8529 23 of of IN cord-010119-t1x9gknd 8529 24 de de NNP cord-010119-t1x9gknd 8529 25 novo novo NNP cord-010119-t1x9gknd 8529 26 alloantibodies alloantibody NNS cord-010119-t1x9gknd 8529 27 during during IN cord-010119-t1x9gknd 8529 28 Dara Dara NNP cord-010119-t1x9gknd 8529 29 treatment treatment NN cord-010119-t1x9gknd 8529 30 at at IN cord-010119-t1x9gknd 8529 31 our -PRON- PRP$ cord-010119-t1x9gknd 8529 32 institution institution NN cord-010119-t1x9gknd 8529 33 . . . cord-010119-t1x9gknd 8530 1 Study Study NNP cord-010119-t1x9gknd 8530 2 Design Design NNP cord-010119-t1x9gknd 8530 3 / / SYM cord-010119-t1x9gknd 8530 4 Method method NN cord-010119-t1x9gknd 8530 5 : : : cord-010119-t1x9gknd 8531 1 All all DT cord-010119-t1x9gknd 8531 2 Dara Dara NNP cord-010119-t1x9gknd 8531 3 patients patient NNS cord-010119-t1x9gknd 8531 4 ' ' POS cord-010119-t1x9gknd 8531 5 antibody antibody NN cord-010119-t1x9gknd 8531 6 workups workup NNS cord-010119-t1x9gknd 8531 7 were be VBD cord-010119-t1x9gknd 8531 8 completed complete VBN cord-010119-t1x9gknd 8531 9 using use VBG cord-010119-t1x9gknd 8531 10 DTT DTT NNP cord-010119-t1x9gknd 8531 11 pre pre VBN cord-010119-t1x9gknd 8531 12 - - VBN cord-010119-t1x9gknd 8531 13 treated treated JJ cord-010119-t1x9gknd 8531 14 reagent reagent JJ cord-010119-t1x9gknd 8531 15 red red JJ cord-010119-t1x9gknd 8531 16 blood blood NN cord-010119-t1x9gknd 8531 17 cells cell NNS cord-010119-t1x9gknd 8531 18 . . . cord-010119-t1x9gknd 8532 1 If if IN cord-010119-t1x9gknd 8532 2 the the DT cord-010119-t1x9gknd 8532 3 antibody antibody NN cord-010119-t1x9gknd 8532 4 screen screen NN cord-010119-t1x9gknd 8532 5 was be VBD cord-010119-t1x9gknd 8532 6 negative negative JJ cord-010119-t1x9gknd 8532 7 , , , cord-010119-t1x9gknd 8532 8 K K NNP cord-010119-t1x9gknd 8532 9 antigen antigen NN cord-010119-t1x9gknd 8532 10 negative negative JJ cord-010119-t1x9gknd 8532 11 RBC RBC NNP cord-010119-t1x9gknd 8532 12 products product NNS cord-010119-t1x9gknd 8532 13 are be VBP cord-010119-t1x9gknd 8532 14 provided provide VBN cord-010119-t1x9gknd 8532 15 . . . cord-010119-t1x9gknd 8533 1 If if IN cord-010119-t1x9gknd 8533 2 an an DT cord-010119-t1x9gknd 8533 3 antibody antibody NN cord-010119-t1x9gknd 8533 4 is be VBZ cord-010119-t1x9gknd 8533 5 identified identify VBN cord-010119-t1x9gknd 8533 6 , , , cord-010119-t1x9gknd 8533 7 K K NNP cord-010119-t1x9gknd 8533 8 negative negative JJ cord-010119-t1x9gknd 8533 9 along along IN cord-010119-t1x9gknd 8533 10 with with IN cord-010119-t1x9gknd 8533 11 that that DT cord-010119-t1x9gknd 8533 12 particular particular JJ cord-010119-t1x9gknd 8533 13 antigen antigen NN cord-010119-t1x9gknd 8533 14 negative negative JJ cord-010119-t1x9gknd 8533 15 blood blood NN cord-010119-t1x9gknd 8533 16 is be VBZ cord-010119-t1x9gknd 8533 17 provided provide VBN cord-010119-t1x9gknd 8533 18 . . . cord-010119-t1x9gknd 8534 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8534 2 electronic electronic JJ cord-010119-t1x9gknd 8534 3 medical medical JJ cord-010119-t1x9gknd 8534 4 record record NN cord-010119-t1x9gknd 8534 5 ( ( -LRB- cord-010119-t1x9gknd 8534 6 EMR EMR NNP cord-010119-t1x9gknd 8534 7 ) ) -RRB- cord-010119-t1x9gknd 8534 8 was be VBD cord-010119-t1x9gknd 8534 9 searched search VBN cord-010119-t1x9gknd 8534 10 for for IN cord-010119-t1x9gknd 8534 11 patients patient NNS cord-010119-t1x9gknd 8534 12 who who WP cord-010119-t1x9gknd 8534 13 received receive VBD cord-010119-t1x9gknd 8534 14 Dara Dara NNP cord-010119-t1x9gknd 8534 15 over over IN cord-010119-t1x9gknd 8534 16 the the DT cord-010119-t1x9gknd 8534 17 past past JJ cord-010119-t1x9gknd 8534 18 eight eight CD cord-010119-t1x9gknd 8534 19 months month NNS cord-010119-t1x9gknd 8534 20 . . . cord-010119-t1x9gknd 8535 1 Study study NN cord-010119-t1x9gknd 8535 2 subjects subject NNS cord-010119-t1x9gknd 8535 3 were be VBD cord-010119-t1x9gknd 8535 4 examined examine VBN cord-010119-t1x9gknd 8535 5 to to TO cord-010119-t1x9gknd 8535 6 see see VB cord-010119-t1x9gknd 8535 7 if if IN cord-010119-t1x9gknd 8535 8 they -PRON- PRP cord-010119-t1x9gknd 8535 9 had have VBD cord-010119-t1x9gknd 8535 10 pre pre VBN cord-010119-t1x9gknd 8535 11 - - JJ cord-010119-t1x9gknd 8535 12 existing existing JJ cord-010119-t1x9gknd 8535 13 alloantibodies alloantibody NNS cord-010119-t1x9gknd 8535 14 before before IN cord-010119-t1x9gknd 8535 15 Dara Dara NNP cord-010119-t1x9gknd 8535 16 treatment treatment NN cord-010119-t1x9gknd 8535 17 and and CC cord-010119-t1x9gknd 8535 18 whether whether IN cord-010119-t1x9gknd 8535 19 they -PRON- PRP cord-010119-t1x9gknd 8535 20 formed form VBD cord-010119-t1x9gknd 8535 21 new new JJ cord-010119-t1x9gknd 8535 22 alloantibodies alloantibody NNS cord-010119-t1x9gknd 8535 23 during during IN cord-010119-t1x9gknd 8535 24 Dara Dara NNP cord-010119-t1x9gknd 8535 25 treatment treatment NN cord-010119-t1x9gknd 8535 26 . . . cord-010119-t1x9gknd 8536 1 The the DT cord-010119-t1x9gknd 8536 2 age age NN cord-010119-t1x9gknd 8536 3 , , , cord-010119-t1x9gknd 8536 4 gender gender NN cord-010119-t1x9gknd 8536 5 , , , cord-010119-t1x9gknd 8536 6 type type NN cord-010119-t1x9gknd 8536 7 and and CC cord-010119-t1x9gknd 8536 8 screen screen NN cord-010119-t1x9gknd 8536 9 pre pre JJ cord-010119-t1x9gknd 8536 10 - - JJ cord-010119-t1x9gknd 8536 11 Dara Dara NNP cord-010119-t1x9gknd 8536 12 treatment treatment NN cord-010119-t1x9gknd 8536 13 , , , cord-010119-t1x9gknd 8536 14 type type NN cord-010119-t1x9gknd 8536 15 and and CC cord-010119-t1x9gknd 8536 16 screen screen NN cord-010119-t1x9gknd 8536 17 post post NN cord-010119-t1x9gknd 8536 18 - - JJ cord-010119-t1x9gknd 8536 19 Dara Dara NNP cord-010119-t1x9gknd 8536 20 , , , cord-010119-t1x9gknd 8536 21 intervening intervene VBG cord-010119-t1x9gknd 8536 22 blood blood NN cord-010119-t1x9gknd 8536 23 transfusions transfusion NNS cord-010119-t1x9gknd 8536 24 , , , cord-010119-t1x9gknd 8536 25 and and CC cord-010119-t1x9gknd 8536 26 the the DT cord-010119-t1x9gknd 8536 27 date date NN cord-010119-t1x9gknd 8536 28 of of IN cord-010119-t1x9gknd 8536 29 first first JJ cord-010119-t1x9gknd 8536 30 Dara Dara NNP cord-010119-t1x9gknd 8536 31 treatment treatment NN cord-010119-t1x9gknd 8536 32 was be VBD cord-010119-t1x9gknd 8536 33 recorded record VBN cord-010119-t1x9gknd 8536 34 . . . cord-010119-t1x9gknd 8537 1 Results result NNS cord-010119-t1x9gknd 8537 2 / / SYM cord-010119-t1x9gknd 8537 3 Finding finding NN cord-010119-t1x9gknd 8537 4 : : : cord-010119-t1x9gknd 8537 5 Overall overall RB cord-010119-t1x9gknd 8537 6 , , , cord-010119-t1x9gknd 8537 7 54 54 CD cord-010119-t1x9gknd 8537 8 subjects subject NNS cord-010119-t1x9gknd 8537 9 were be VBD cord-010119-t1x9gknd 8537 10 identified identify VBN cord-010119-t1x9gknd 8537 11 for for IN cord-010119-t1x9gknd 8537 12 analysis analysis NN cord-010119-t1x9gknd 8537 13 . . . cord-010119-t1x9gknd 8538 1 Their -PRON- PRP$ cord-010119-t1x9gknd 8538 2 mean mean JJ cord-010119-t1x9gknd 8538 3 age age NN cord-010119-t1x9gknd 8538 4 was be VBD cord-010119-t1x9gknd 8538 5 67.8 67.8 CD cord-010119-t1x9gknd 8538 6 years year NNS cord-010119-t1x9gknd 8538 7 , , , cord-010119-t1x9gknd 8538 8 with with IN cord-010119-t1x9gknd 8538 9 29 29 CD cord-010119-t1x9gknd 8538 10 male male NN cord-010119-t1x9gknd 8538 11 and and CC cord-010119-t1x9gknd 8538 12 25 25 CD cord-010119-t1x9gknd 8538 13 female female JJ cord-010119-t1x9gknd 8538 14 subjects subject NNS cord-010119-t1x9gknd 8538 15 ; ; : cord-010119-t1x9gknd 8538 16 all all DT cord-010119-t1x9gknd 8538 17 were be VBD cord-010119-t1x9gknd 8538 18 diagnosed diagnose VBN cord-010119-t1x9gknd 8538 19 with with IN cord-010119-t1x9gknd 8538 20 multiple multiple JJ cord-010119-t1x9gknd 8538 21 myeloma myeloma NN cord-010119-t1x9gknd 8538 22 . . . cord-010119-t1x9gknd 8539 1 We -PRON- PRP cord-010119-t1x9gknd 8539 2 found find VBD cord-010119-t1x9gknd 8539 3 an an DT cord-010119-t1x9gknd 8539 4 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8539 5 rate rate NN cord-010119-t1x9gknd 8539 6 of of IN cord-010119-t1x9gknd 8539 7 0 0 CD cord-010119-t1x9gknd 8539 8 % % NN cord-010119-t1x9gknd 8539 9 ( ( -LRB- cord-010119-t1x9gknd 8539 10 0/54 0/54 CD cord-010119-t1x9gknd 8539 11 ) ) -RRB- cord-010119-t1x9gknd 8539 12 prior prior RB cord-010119-t1x9gknd 8539 13 to to IN cord-010119-t1x9gknd 8539 14 administration administration NN cord-010119-t1x9gknd 8539 15 of of IN cord-010119-t1x9gknd 8539 16 Dara Dara NNP cord-010119-t1x9gknd 8539 17 . . . cord-010119-t1x9gknd 8540 1 Of of IN cord-010119-t1x9gknd 8540 2 these these DT cord-010119-t1x9gknd 8540 3 patients patient NNS cord-010119-t1x9gknd 8540 4 , , , cord-010119-t1x9gknd 8540 5 22 22 CD cord-010119-t1x9gknd 8540 6 were be VBD cord-010119-t1x9gknd 8540 7 transfused transfuse VBN cord-010119-t1x9gknd 8540 8 with with IN cord-010119-t1x9gknd 8540 9 red red JJ cord-010119-t1x9gknd 8540 10 blood blood NN cord-010119-t1x9gknd 8540 11 cells cell NNS cord-010119-t1x9gknd 8540 12 ( ( -LRB- cord-010119-t1x9gknd 8540 13 RBCs rbc NNS cord-010119-t1x9gknd 8540 14 ) ) -RRB- cord-010119-t1x9gknd 8540 15 after after IN cord-010119-t1x9gknd 8540 16 initiation initiation NN cord-010119-t1x9gknd 8540 17 of of IN cord-010119-t1x9gknd 8540 18 Dara Dara NNP cord-010119-t1x9gknd 8540 19 therapy therapy NN cord-010119-t1x9gknd 8540 20 . . . cord-010119-t1x9gknd 8541 1 Following follow VBG cord-010119-t1x9gknd 8541 2 our -PRON- PRP$ cord-010119-t1x9gknd 8541 3 testing testing NN cord-010119-t1x9gknd 8541 4 / / SYM cord-010119-t1x9gknd 8541 5 matching matching NN cord-010119-t1x9gknd 8541 6 protocol protocol NN cord-010119-t1x9gknd 8541 7 , , , cord-010119-t1x9gknd 8541 8 none none NN cord-010119-t1x9gknd 8541 9 of of IN cord-010119-t1x9gknd 8541 10 these these DT cord-010119-t1x9gknd 8541 11 ( ( -LRB- cord-010119-t1x9gknd 8541 12 0 0 CD cord-010119-t1x9gknd 8541 13 % % NN cord-010119-t1x9gknd 8541 14 ; ; : cord-010119-t1x9gknd 8541 15 0/22 0/22 CD cord-010119-t1x9gknd 8541 16 ) ) -RRB- cord-010119-t1x9gknd 8541 17 patients patient NNS cord-010119-t1x9gknd 8541 18 formed form VBD cord-010119-t1x9gknd 8541 19 a a DT cord-010119-t1x9gknd 8541 20 confirmed confirm VBN cord-010119-t1x9gknd 8541 21 , , , cord-010119-t1x9gknd 8541 22 new new JJ cord-010119-t1x9gknd 8541 23 alloantibody alloantibody NN cord-010119-t1x9gknd 8541 24 during during IN cord-010119-t1x9gknd 8541 25 Dara Dara NNP cord-010119-t1x9gknd 8541 26 treatment treatment NN cord-010119-t1x9gknd 8541 27 ; ; : cord-010119-t1x9gknd 8541 28 each each DT cord-010119-t1x9gknd 8541 29 of of IN cord-010119-t1x9gknd 8541 30 these these DT cord-010119-t1x9gknd 8541 31 patients patient NNS cord-010119-t1x9gknd 8541 32 underwent undergo VBD cord-010119-t1x9gknd 8541 33 at at RB cord-010119-t1x9gknd 8541 34 least least RBS cord-010119-t1x9gknd 8541 35 one one CD cord-010119-t1x9gknd 8541 36 follow follow NN cord-010119-t1x9gknd 8541 37 - - HYPH cord-010119-t1x9gknd 8541 38 up up NN cord-010119-t1x9gknd 8541 39 screen screen NN cord-010119-t1x9gknd 8541 40 after after IN cord-010119-t1x9gknd 8541 41 their -PRON- PRP$ cord-010119-t1x9gknd 8541 42 first first JJ cord-010119-t1x9gknd 8541 43 RBC RBC NNP cord-010119-t1x9gknd 8541 44 unit unit NN cord-010119-t1x9gknd 8541 45 . . . cord-010119-t1x9gknd 8542 1 We -PRON- PRP cord-010119-t1x9gknd 8542 2 also also RB cord-010119-t1x9gknd 8542 3 found find VBD cord-010119-t1x9gknd 8542 4 no no DT cord-010119-t1x9gknd 8542 5 complications complication NNS cord-010119-t1x9gknd 8542 6 in in IN cord-010119-t1x9gknd 8542 7 providing provide VBG cord-010119-t1x9gknd 8542 8 crossmatch crossmatch NN cord-010119-t1x9gknd 8542 9 compatible compatible JJ cord-010119-t1x9gknd 8542 10 units unit NNS cord-010119-t1x9gknd 8542 11 to to IN cord-010119-t1x9gknd 8542 12 any any DT cord-010119-t1x9gknd 8542 13 of of IN cord-010119-t1x9gknd 8542 14 the the DT cord-010119-t1x9gknd 8542 15 22 22 CD cord-010119-t1x9gknd 8542 16 patients patient NNS cord-010119-t1x9gknd 8542 17 . . . cord-010119-t1x9gknd 8543 1 Conclusion conclusion NN cord-010119-t1x9gknd 8543 2 : : : cord-010119-t1x9gknd 8544 1 To to IN cord-010119-t1x9gknd 8544 2 our -PRON- PRP$ cord-010119-t1x9gknd 8544 3 knowledge knowledge NN cord-010119-t1x9gknd 8544 4 , , , cord-010119-t1x9gknd 8544 5 this this DT cord-010119-t1x9gknd 8544 6 is be VBZ cord-010119-t1x9gknd 8544 7 the the DT cord-010119-t1x9gknd 8544 8 largest large JJS cord-010119-t1x9gknd 8544 9 case case NN cord-010119-t1x9gknd 8544 10 series series NN cord-010119-t1x9gknd 8544 11 reporting report VBG cord-010119-t1x9gknd 8544 12 on on IN cord-010119-t1x9gknd 8544 13 results result NNS cord-010119-t1x9gknd 8544 14 of of IN cord-010119-t1x9gknd 8544 15 overcoming overcome VBG cord-010119-t1x9gknd 8544 16 Dara Dara NNP cord-010119-t1x9gknd 8544 17 interference interference NN cord-010119-t1x9gknd 8544 18 with with IN cord-010119-t1x9gknd 8544 19 blood blood NN cord-010119-t1x9gknd 8544 20 bank bank NN cord-010119-t1x9gknd 8544 21 type type NN cord-010119-t1x9gknd 8544 22 and and CC cord-010119-t1x9gknd 8544 23 screen screen NN cord-010119-t1x9gknd 8544 24 testing testing NN cord-010119-t1x9gknd 8544 25 . . . cord-010119-t1x9gknd 8545 1 The the DT cord-010119-t1x9gknd 8545 2 protocol protocol NN cord-010119-t1x9gknd 8545 3 implemented implement VBN cord-010119-t1x9gknd 8545 4 in in IN cord-010119-t1x9gknd 8545 5 our -PRON- PRP$ cord-010119-t1x9gknd 8545 6 laboratory laboratory NN cord-010119-t1x9gknd 8545 7 appears appear VBZ cord-010119-t1x9gknd 8545 8 to to TO cord-010119-t1x9gknd 8545 9 be be VB cord-010119-t1x9gknd 8545 10 successful successful JJ cord-010119-t1x9gknd 8545 11 in in IN cord-010119-t1x9gknd 8545 12 providing provide VBG cord-010119-t1x9gknd 8545 13 compatible compatible JJ cord-010119-t1x9gknd 8545 14 units unit NNS cord-010119-t1x9gknd 8545 15 and and CC cord-010119-t1x9gknd 8545 16 preventing prevent VBG cord-010119-t1x9gknd 8545 17 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8545 18 in in IN cord-010119-t1x9gknd 8545 19 patients patient NNS cord-010119-t1x9gknd 8545 20 receiving receive VBG cord-010119-t1x9gknd 8545 21 Dara Dara NNP cord-010119-t1x9gknd 8545 22 therapy therapy NN cord-010119-t1x9gknd 8545 23 . . . cord-010119-t1x9gknd 8546 1 It -PRON- PRP cord-010119-t1x9gknd 8546 2 is be VBZ cord-010119-t1x9gknd 8546 3 possible possible JJ cord-010119-t1x9gknd 8546 4 that that IN cord-010119-t1x9gknd 8546 5 the the DT cord-010119-t1x9gknd 8546 6 drug drug NN cord-010119-t1x9gknd 8546 7 , , , cord-010119-t1x9gknd 8546 8 targeting target VBG cord-010119-t1x9gknd 8546 9 antibody antibody NN cord-010119-t1x9gknd 8546 10 forming form VBG cord-010119-t1x9gknd 8546 11 cells cell NNS cord-010119-t1x9gknd 8546 12 , , , cord-010119-t1x9gknd 8546 13 may may MD cord-010119-t1x9gknd 8546 14 have have VB cord-010119-t1x9gknd 8546 15 an an DT cord-010119-t1x9gknd 8546 16 immunosuppressive immunosuppressive JJ cord-010119-t1x9gknd 8546 17 effect effect NN cord-010119-t1x9gknd 8546 18 on on IN cord-010119-t1x9gknd 8546 19 the the DT cord-010119-t1x9gknd 8546 20 humoral humoral JJ cord-010119-t1x9gknd 8546 21 response response NN cord-010119-t1x9gknd 8546 22 ; ; : cord-010119-t1x9gknd 8546 23 further further JJ cord-010119-t1x9gknd 8546 24 studies study NNS cord-010119-t1x9gknd 8546 25 of of IN cord-010119-t1x9gknd 8546 26 this this DT cord-010119-t1x9gknd 8546 27 effect effect NN cord-010119-t1x9gknd 8546 28 may may MD cord-010119-t1x9gknd 8546 29 be be VB cord-010119-t1x9gknd 8546 30 warranted warrant VBN cord-010119-t1x9gknd 8546 31 . . . cord-010119-t1x9gknd 8547 1 Background Background NNP cord-010119-t1x9gknd 8547 2 / / SYM cord-010119-t1x9gknd 8547 3 Case Case NNP cord-010119-t1x9gknd 8547 4 Studies Studies NNPS cord-010119-t1x9gknd 8548 1 : : : cord-010119-t1x9gknd 8548 2 A a DT cord-010119-t1x9gknd 8548 3 multi multi JJ cord-010119-t1x9gknd 8548 4 - - JJ cord-010119-t1x9gknd 8548 5 facility facility JJ cord-010119-t1x9gknd 8548 6 transfusion transfusion NN cord-010119-t1x9gknd 8548 7 service service NN cord-010119-t1x9gknd 8548 8 began begin VBD cord-010119-t1x9gknd 8548 9 stocking stock VBG cord-010119-t1x9gknd 8548 10 liquid liquid JJ cord-010119-t1x9gknd 8548 11 plasma plasma NN cord-010119-t1x9gknd 8548 12 in in IN cord-010119-t1x9gknd 8548 13 September September NNP cord-010119-t1x9gknd 8548 14 of of IN cord-010119-t1x9gknd 8548 15 2015 2015 CD cord-010119-t1x9gknd 8548 16 for for IN cord-010119-t1x9gknd 8548 17 use use NN cord-010119-t1x9gknd 8548 18 in in IN cord-010119-t1x9gknd 8548 19 massive massive JJ cord-010119-t1x9gknd 8548 20 transfusion transfusion NN cord-010119-t1x9gknd 8548 21 and and CC cord-010119-t1x9gknd 8548 22 trauma trauma NN cord-010119-t1x9gknd 8548 23 situations situation NNS cord-010119-t1x9gknd 8548 24 . . . cord-010119-t1x9gknd 8549 1 Due due IN cord-010119-t1x9gknd 8549 2 to to IN cord-010119-t1x9gknd 8549 3 the the DT cord-010119-t1x9gknd 8549 4 infrequent infrequent JJ cord-010119-t1x9gknd 8549 5 occurrence occurrence NN cord-010119-t1x9gknd 8549 6 of of IN cord-010119-t1x9gknd 8549 7 these these DT cord-010119-t1x9gknd 8549 8 incidents incident NNS cord-010119-t1x9gknd 8549 9 , , , cord-010119-t1x9gknd 8549 10 the the DT cord-010119-t1x9gknd 8549 11 liquid liquid JJ cord-010119-t1x9gknd 8549 12 plasma plasma NN cord-010119-t1x9gknd 8549 13 would would MD cord-010119-t1x9gknd 8549 14 outdate outdate VB cord-010119-t1x9gknd 8549 15 before before IN cord-010119-t1x9gknd 8549 16 use use NN cord-010119-t1x9gknd 8549 17 . . . cord-010119-t1x9gknd 8550 1 A a DT cord-010119-t1x9gknd 8550 2 policy policy NN cord-010119-t1x9gknd 8550 3 to to TO cord-010119-t1x9gknd 8550 4 use use VB cord-010119-t1x9gknd 8550 5 liquid liquid JJ cord-010119-t1x9gknd 8550 6 plasma plasma NN cord-010119-t1x9gknd 8550 7 in in IN cord-010119-t1x9gknd 8550 8 nonemergent nonemergent NN cord-010119-t1x9gknd 8550 9 situations situation NNS cord-010119-t1x9gknd 8550 10 when when WRB cord-010119-t1x9gknd 8550 11 the the DT cord-010119-t1x9gknd 8550 12 units unit NNS cord-010119-t1x9gknd 8550 13 were be VBD cord-010119-t1x9gknd 8550 14 nearing near VBG cord-010119-t1x9gknd 8550 15 their -PRON- PRP$ cord-010119-t1x9gknd 8550 16 expiration expiration NN cord-010119-t1x9gknd 8550 17 dates date NNS cord-010119-t1x9gknd 8550 18 was be VBD cord-010119-t1x9gknd 8550 19 implemented implement VBN cord-010119-t1x9gknd 8550 20 . . . cord-010119-t1x9gknd 8551 1 This this DT cord-010119-t1x9gknd 8551 2 study study NN cord-010119-t1x9gknd 8551 3 evaluated evaluate VBD cord-010119-t1x9gknd 8551 4 the the DT cord-010119-t1x9gknd 8551 5 effects effect NNS cord-010119-t1x9gknd 8551 6 of of IN cord-010119-t1x9gknd 8551 7 that that DT cord-010119-t1x9gknd 8551 8 policy policy NN cord-010119-t1x9gknd 8551 9 on on IN cord-010119-t1x9gknd 8551 10 INR INR NNP cord-010119-t1x9gknd 8551 11 values value NNS cord-010119-t1x9gknd 8551 12 of of IN cord-010119-t1x9gknd 8551 13 plasma plasma NN cord-010119-t1x9gknd 8551 14 recipients recipient NNS cord-010119-t1x9gknd 8551 15 . . . cord-010119-t1x9gknd 8552 1 Study Study NNP cord-010119-t1x9gknd 8552 2 Design Design NNP cord-010119-t1x9gknd 8552 3 / / SYM cord-010119-t1x9gknd 8552 4 Methods method NNS cord-010119-t1x9gknd 8552 5 : : : cord-010119-t1x9gknd 8552 6 A a DT cord-010119-t1x9gknd 8552 7 retrospective retrospective JJ cord-010119-t1x9gknd 8552 8 analysis analysis NN cord-010119-t1x9gknd 8552 9 was be VBD cord-010119-t1x9gknd 8552 10 developed develop VBN cord-010119-t1x9gknd 8552 11 to to TO cord-010119-t1x9gknd 8552 12 compare compare VB cord-010119-t1x9gknd 8552 13 the the DT cord-010119-t1x9gknd 8552 14 effectiveness effectiveness NN cord-010119-t1x9gknd 8552 15 of of IN cord-010119-t1x9gknd 8552 16 fresh fresh JJ cord-010119-t1x9gknd 8552 17 frozen frozen JJ cord-010119-t1x9gknd 8552 18 plasma plasma NN cord-010119-t1x9gknd 8552 19 ( ( -LRB- cord-010119-t1x9gknd 8552 20 FFP FFP NNP cord-010119-t1x9gknd 8552 21 ) ) -RRB- cord-010119-t1x9gknd 8552 22 and and CC cord-010119-t1x9gknd 8552 23 liquid liquid JJ cord-010119-t1x9gknd 8552 24 plasma plasma NN cord-010119-t1x9gknd 8552 25 ( ( -LRB- cord-010119-t1x9gknd 8552 26 LQP LQP NNP cord-010119-t1x9gknd 8552 27 ) ) -RRB- cord-010119-t1x9gknd 8552 28 in in IN cord-010119-t1x9gknd 8552 29 changing change VBG cord-010119-t1x9gknd 8552 30 INR INR NNP cord-010119-t1x9gknd 8552 31 values value NNS cord-010119-t1x9gknd 8552 32 of of IN cord-010119-t1x9gknd 8552 33 recipients recipient NNS cord-010119-t1x9gknd 8552 34 . . . cord-010119-t1x9gknd 8553 1 All all DT cord-010119-t1x9gknd 8553 2 plasma plasma NN cord-010119-t1x9gknd 8553 3 units unit NNS cord-010119-t1x9gknd 8553 4 transfused transfuse VBN cord-010119-t1x9gknd 8553 5 within within IN cord-010119-t1x9gknd 8553 6 the the DT cord-010119-t1x9gknd 8553 7 facility facility NN cord-010119-t1x9gknd 8553 8 from from IN cord-010119-t1x9gknd 8553 9 September September NNP cord-010119-t1x9gknd 8553 10 1 1 CD cord-010119-t1x9gknd 8553 11 , , , cord-010119-t1x9gknd 8553 12 2015 2015 CD cord-010119-t1x9gknd 8553 13 through through IN cord-010119-t1x9gknd 8553 14 April April NNP cord-010119-t1x9gknd 8553 15 7 7 CD cord-010119-t1x9gknd 8553 16 , , , cord-010119-t1x9gknd 8553 17 2017 2017 CD cord-010119-t1x9gknd 8553 18 were be VBD cord-010119-t1x9gknd 8553 19 identified identify VBN cord-010119-t1x9gknd 8553 20 . . . cord-010119-t1x9gknd 8554 1 The the DT cord-010119-t1x9gknd 8554 2 following follow VBG cord-010119-t1x9gknd 8554 3 data datum NNS cord-010119-t1x9gknd 8554 4 was be VBD cord-010119-t1x9gknd 8554 5 obtained obtain VBN cord-010119-t1x9gknd 8554 6 from from IN cord-010119-t1x9gknd 8554 7 the the DT cord-010119-t1x9gknd 8554 8 hospital hospital NN cord-010119-t1x9gknd 8554 9 and and CC cord-010119-t1x9gknd 8554 10 laboratory laboratory NN cord-010119-t1x9gknd 8554 11 information information NN cord-010119-t1x9gknd 8554 12 systems system NNS cord-010119-t1x9gknd 8554 13 for for IN cord-010119-t1x9gknd 8554 14 each each DT cord-010119-t1x9gknd 8554 15 unit unit NN cord-010119-t1x9gknd 8554 16 : : : cord-010119-t1x9gknd 8554 17 the the DT cord-010119-t1x9gknd 8554 18 recipient recipient NN cord-010119-t1x9gknd 8554 19 , , , cord-010119-t1x9gknd 8554 20 primary primary JJ cord-010119-t1x9gknd 8554 21 reason reason NN cord-010119-t1x9gknd 8554 22 for for IN cord-010119-t1x9gknd 8554 23 transfusion transfusion NN cord-010119-t1x9gknd 8554 24 of of IN cord-010119-t1x9gknd 8554 25 plasma plasma NN cord-010119-t1x9gknd 8554 26 , , , cord-010119-t1x9gknd 8554 27 number number NN cord-010119-t1x9gknd 8554 28 of of IN cord-010119-t1x9gknd 8554 29 plasma plasma NN cord-010119-t1x9gknd 8554 30 units unit NNS cord-010119-t1x9gknd 8554 31 transfused transfuse VBN cord-010119-t1x9gknd 8554 32 , , , cord-010119-t1x9gknd 8554 33 type type NN cord-010119-t1x9gknd 8554 34 of of IN cord-010119-t1x9gknd 8554 35 plasma plasma NN cord-010119-t1x9gknd 8554 36 transfused transfuse VBN cord-010119-t1x9gknd 8554 37 , , , cord-010119-t1x9gknd 8554 38 preand preand JJ cord-010119-t1x9gknd 8554 39 post post JJ cord-010119-t1x9gknd 8554 40 - - JJ cord-010119-t1x9gknd 8554 41 transfusion transfusion NN cord-010119-t1x9gknd 8554 42 INR INR NNP cord-010119-t1x9gknd 8554 43 values value NNS cord-010119-t1x9gknd 8554 44 , , , cord-010119-t1x9gknd 8554 45 and and CC cord-010119-t1x9gknd 8554 46 whether whether IN cord-010119-t1x9gknd 8554 47 or or CC cord-010119-t1x9gknd 8554 48 not not RB cord-010119-t1x9gknd 8554 49 vitamin vitamin NN cord-010119-t1x9gknd 8554 50 K K NNP cord-010119-t1x9gknd 8554 51 was be VBD cord-010119-t1x9gknd 8554 52 administered administer VBN cord-010119-t1x9gknd 8554 53 . . . cord-010119-t1x9gknd 8555 1 Patients patient NNS cord-010119-t1x9gknd 8555 2 were be VBD cord-010119-t1x9gknd 8555 3 divided divide VBN cord-010119-t1x9gknd 8555 4 into into IN cord-010119-t1x9gknd 8555 5 groups group NNS cord-010119-t1x9gknd 8555 6 based base VBN cord-010119-t1x9gknd 8555 7 on on IN cord-010119-t1x9gknd 8555 8 the the DT cord-010119-t1x9gknd 8555 9 type type NN cord-010119-t1x9gknd 8555 10 of of IN cord-010119-t1x9gknd 8555 11 plasma plasma NN cord-010119-t1x9gknd 8555 12 units unit NNS cord-010119-t1x9gknd 8555 13 transfused transfuse VBN cord-010119-t1x9gknd 8555 14 and and CC cord-010119-t1x9gknd 8555 15 were be VBD cord-010119-t1x9gknd 8555 16 evaluated evaluate VBN cord-010119-t1x9gknd 8555 17 based base VBN cord-010119-t1x9gknd 8555 18 on on IN cord-010119-t1x9gknd 8555 19 primary primary JJ cord-010119-t1x9gknd 8555 20 reason reason NN cord-010119-t1x9gknd 8555 21 for for IN cord-010119-t1x9gknd 8555 22 transfusion transfusion NN cord-010119-t1x9gknd 8555 23 , , , cord-010119-t1x9gknd 8555 24 number number NN cord-010119-t1x9gknd 8555 25 of of IN cord-010119-t1x9gknd 8555 26 units unit NNS cord-010119-t1x9gknd 8555 27 transfused transfuse VBN cord-010119-t1x9gknd 8555 28 , , , cord-010119-t1x9gknd 8555 29 and and CC cord-010119-t1x9gknd 8555 30 administration administration NN cord-010119-t1x9gknd 8555 31 of of IN cord-010119-t1x9gknd 8555 32 vitamin vitamin NN cord-010119-t1x9gknd 8555 33 K. K. NNP cord-010119-t1x9gknd 8556 1 The the DT cord-010119-t1x9gknd 8556 2 change change NN cord-010119-t1x9gknd 8556 3 in in IN cord-010119-t1x9gknd 8556 4 INR INR NNP cord-010119-t1x9gknd 8556 5 for for IN cord-010119-t1x9gknd 8556 6 each each DT cord-010119-t1x9gknd 8556 7 recipient recipient NN cord-010119-t1x9gknd 8556 8 was be VBD cord-010119-t1x9gknd 8556 9 calculated calculate VBN cord-010119-t1x9gknd 8556 10 , , , cord-010119-t1x9gknd 8556 11 along along IN cord-010119-t1x9gknd 8556 12 with with IN cord-010119-t1x9gknd 8556 13 the the DT cord-010119-t1x9gknd 8556 14 average average JJ cord-010119-t1x9gknd 8556 15 change change NN cord-010119-t1x9gknd 8556 16 in in IN cord-010119-t1x9gknd 8556 17 INR INR NNP cord-010119-t1x9gknd 8556 18 for for IN cord-010119-t1x9gknd 8556 19 each each DT cord-010119-t1x9gknd 8556 20 group group NN cord-010119-t1x9gknd 8556 21 . . . cord-010119-t1x9gknd 8557 1 Background Background NNP cord-010119-t1x9gknd 8557 2 / / SYM cord-010119-t1x9gknd 8557 3 Case Case NNP cord-010119-t1x9gknd 8557 4 Studies Studies NNPS cord-010119-t1x9gknd 8557 5 : : : cord-010119-t1x9gknd 8558 1 In in IN cord-010119-t1x9gknd 8558 2 gynaecological gynaecological JJ cord-010119-t1x9gknd 8558 3 settings setting NNS cord-010119-t1x9gknd 8558 4 , , , cord-010119-t1x9gknd 8558 5 most most JJS cord-010119-t1x9gknd 8558 6 but but CC cord-010119-t1x9gknd 8558 7 not not RB cord-010119-t1x9gknd 8558 8 all all DT cord-010119-t1x9gknd 8558 9 relatively relatively RB cord-010119-t1x9gknd 8558 10 young young JJ cord-010119-t1x9gknd 8558 11 anaemic anaemic JJ cord-010119-t1x9gknd 8558 12 women woman NNS cord-010119-t1x9gknd 8558 13 are be VBP cord-010119-t1x9gknd 8558 14 iron iron NN cord-010119-t1x9gknd 8558 15 deficient deficient JJ cord-010119-t1x9gknd 8558 16 due due IN cord-010119-t1x9gknd 8558 17 to to IN cord-010119-t1x9gknd 8558 18 blood blood NN cord-010119-t1x9gknd 8558 19 loss loss NN cord-010119-t1x9gknd 8558 20 associated associate VBN cord-010119-t1x9gknd 8558 21 with with IN cord-010119-t1x9gknd 8558 22 menstruation menstruation NN cord-010119-t1x9gknd 8558 23 . . . cord-010119-t1x9gknd 8559 1 Transfusion transfusion NN cord-010119-t1x9gknd 8559 2 could could MD cord-010119-t1x9gknd 8559 3 generally generally RB cord-010119-t1x9gknd 8559 4 be be VB cord-010119-t1x9gknd 8559 5 avoided avoid VBN cord-010119-t1x9gknd 8559 6 in in IN cord-010119-t1x9gknd 8559 7 those those DT cord-010119-t1x9gknd 8559 8 without without IN cord-010119-t1x9gknd 8559 9 haemodynamic haemodynamic JJ cord-010119-t1x9gknd 8559 10 instability instability NN cord-010119-t1x9gknd 8559 11 . . . cord-010119-t1x9gknd 8560 1 The the DT cord-010119-t1x9gknd 8560 2 oral oral JJ cord-010119-t1x9gknd 8560 3 antifibrinolytic antifibrinolytic JJ cord-010119-t1x9gknd 8560 4 drug drug NN cord-010119-t1x9gknd 8560 5 tranexamic tranexamic NNP cord-010119-t1x9gknd 8560 6 acid acid NN cord-010119-t1x9gknd 8560 7 is be VBZ cord-010119-t1x9gknd 8560 8 an an DT cord-010119-t1x9gknd 8560 9 effective effective JJ cord-010119-t1x9gknd 8560 10 and and CC cord-010119-t1x9gknd 8560 11 well well RB cord-010119-t1x9gknd 8560 12 tolerated tolerate VBN cord-010119-t1x9gknd 8560 13 treatment treatment NN cord-010119-t1x9gknd 8560 14 for for IN cord-010119-t1x9gknd 8560 15 menorrhagia menorrhagia NN cord-010119-t1x9gknd 8560 16 . . . cord-010119-t1x9gknd 8561 1 Besides besides RB cord-010119-t1x9gknd 8561 2 , , , cord-010119-t1x9gknd 8561 3 iron iron NN cord-010119-t1x9gknd 8561 4 replacement replacement NN cord-010119-t1x9gknd 8561 5 is be VBZ cord-010119-t1x9gknd 8561 6 often often RB cord-010119-t1x9gknd 8561 7 necessary necessary JJ cord-010119-t1x9gknd 8561 8 for for IN cord-010119-t1x9gknd 8561 9 a a DT cord-010119-t1x9gknd 8561 10 prolonged prolonged JJ cord-010119-t1x9gknd 8561 11 period period NN cord-010119-t1x9gknd 8561 12 of of IN cord-010119-t1x9gknd 8561 13 time time NN cord-010119-t1x9gknd 8561 14 after after IN cord-010119-t1x9gknd 8561 15 normalization normalization NN cord-010119-t1x9gknd 8561 16 of of IN cord-010119-t1x9gknd 8561 17 haemoglobin haemoglobin NN cord-010119-t1x9gknd 8561 18 ( ( -LRB- cord-010119-t1x9gknd 8561 19 Hb Hb NNP cord-010119-t1x9gknd 8561 20 ) ) -RRB- cord-010119-t1x9gknd 8561 21 . . . cord-010119-t1x9gknd 8562 1 The the DT cord-010119-t1x9gknd 8562 2 present present JJ cord-010119-t1x9gknd 8562 3 study study NN cord-010119-t1x9gknd 8562 4 attempted attempt VBD cord-010119-t1x9gknd 8562 5 to to TO cord-010119-t1x9gknd 8562 6 look look VB cord-010119-t1x9gknd 8562 7 into into IN cord-010119-t1x9gknd 8562 8 transfusion transfusion NN cord-010119-t1x9gknd 8562 9 appropriateness appropriateness NN cord-010119-t1x9gknd 8562 10 and and CC cord-010119-t1x9gknd 8562 11 the the DT cord-010119-t1x9gknd 8562 12 use use NN cord-010119-t1x9gknd 8562 13 of of IN cord-010119-t1x9gknd 8562 14 iron iron NN cord-010119-t1x9gknd 8562 15 and and CC cord-010119-t1x9gknd 8562 16 tranexamic tranexamic JJ cord-010119-t1x9gknd 8562 17 acid acid NN cord-010119-t1x9gknd 8562 18 in in IN cord-010119-t1x9gknd 8562 19 transfused transfused JJ cord-010119-t1x9gknd 8562 20 women woman NNS cord-010119-t1x9gknd 8562 21 in in IN cord-010119-t1x9gknd 8562 22 Hong Hong NNP cord-010119-t1x9gknd 8562 23 Kong Kong NNP cord-010119-t1x9gknd 8562 24 . . . cord-010119-t1x9gknd 8563 1 Study Study NNP cord-010119-t1x9gknd 8563 2 Design Design NNP cord-010119-t1x9gknd 8563 3 / / SYM cord-010119-t1x9gknd 8563 4 Methods method NNS cord-010119-t1x9gknd 8563 5 : : : cord-010119-t1x9gknd 8564 1 Anonymous anonymous JJ cord-010119-t1x9gknd 8564 2 data datum NNS cord-010119-t1x9gknd 8564 3 of of IN cord-010119-t1x9gknd 8564 4 gynaeological gynaeological JJ cord-010119-t1x9gknd 8564 5 patients patient NNS cord-010119-t1x9gknd 8564 6 age age NN cord-010119-t1x9gknd 8564 7 60 60 CD cord-010119-t1x9gknd 8564 8 was be VBD cord-010119-t1x9gknd 8564 9 retrieved retrieve VBN cord-010119-t1x9gknd 8564 10 from from IN cord-010119-t1x9gknd 8564 11 a a DT cord-010119-t1x9gknd 8564 12 central central JJ cord-010119-t1x9gknd 8564 13 database database NN cord-010119-t1x9gknd 8564 14 of of IN cord-010119-t1x9gknd 8564 15 public public JJ cord-010119-t1x9gknd 8564 16 hospitals hospital NNS cord-010119-t1x9gknd 8564 17 which which WDT cord-010119-t1x9gknd 8564 18 included include VBD cord-010119-t1x9gknd 8564 19 age age NN cord-010119-t1x9gknd 8564 20 , , , cord-010119-t1x9gknd 8564 21 number number NN cord-010119-t1x9gknd 8564 22 of of IN cord-010119-t1x9gknd 8564 23 units unit NNS cord-010119-t1x9gknd 8564 24 of of IN cord-010119-t1x9gknd 8564 25 red red JJ cord-010119-t1x9gknd 8564 26 cell cell NN cord-010119-t1x9gknd 8564 27 transfused transfuse VBN cord-010119-t1x9gknd 8564 28 , , , cord-010119-t1x9gknd 8564 29 pre pre JJ cord-010119-t1x9gknd 8564 30 - - JJ cord-010119-t1x9gknd 8564 31 and and CC cord-010119-t1x9gknd 8564 32 posttransfusion posttransfusion NN cord-010119-t1x9gknd 8565 1 Hb Hb NNP cord-010119-t1x9gknd 8565 2 , , , cord-010119-t1x9gknd 8565 3 the the DT cord-010119-t1x9gknd 8565 4 use use NN cord-010119-t1x9gknd 8565 5 of of IN cord-010119-t1x9gknd 8565 6 iron iron NN cord-010119-t1x9gknd 8565 7 and/or and/or CC cord-010119-t1x9gknd 8565 8 tranexamic tranexamic JJ cord-010119-t1x9gknd 8565 9 acid acid NN cord-010119-t1x9gknd 8565 10 during during IN cord-010119-t1x9gknd 8565 11 hospitalization hospitalization NN cord-010119-t1x9gknd 8565 12 and and CC cord-010119-t1x9gknd 8565 13 upon upon IN cord-010119-t1x9gknd 8565 14 discharge discharge NN cord-010119-t1x9gknd 8565 15 . . . cord-010119-t1x9gknd 8566 1 All all DT cord-010119-t1x9gknd 8566 2 transfusion transfusion NN cord-010119-t1x9gknd 8566 3 episodes episode NNS cord-010119-t1x9gknd 8566 4 associated associate VBN cord-010119-t1x9gknd 8566 5 with with IN cord-010119-t1x9gknd 8566 6 surgical surgical JJ cord-010119-t1x9gknd 8566 7 operations operation NNS cord-010119-t1x9gknd 8566 8 during during IN cord-010119-t1x9gknd 8566 9 same same JJ cord-010119-t1x9gknd 8566 10 admission admission NN cord-010119-t1x9gknd 8566 11 are be VBP cord-010119-t1x9gknd 8566 12 excluded exclude VBN cord-010119-t1x9gknd 8566 13 . . . cord-010119-t1x9gknd 8567 1 Results result NNS cord-010119-t1x9gknd 8567 2 / / SYM cord-010119-t1x9gknd 8567 3 Findings finding NNS cord-010119-t1x9gknd 8567 4 : : : cord-010119-t1x9gknd 8568 1 In in IN cord-010119-t1x9gknd 8568 2 2016 2016 CD cord-010119-t1x9gknd 8568 3 , , , cord-010119-t1x9gknd 8568 4 2,523 2,523 CD cord-010119-t1x9gknd 8568 5 unique unique JJ cord-010119-t1x9gknd 8568 6 women woman NNS cord-010119-t1x9gknd 8568 7 receiving receive VBG cord-010119-t1x9gknd 8568 8 a a DT cord-010119-t1x9gknd 8568 9 total total NN cord-010119-t1x9gknd 8568 10 of of IN cord-010119-t1x9gknd 8568 11 5,889 5,889 CD cord-010119-t1x9gknd 8568 12 units unit NNS cord-010119-t1x9gknd 8568 13 of of IN cord-010119-t1x9gknd 8568 14 red red JJ cord-010119-t1x9gknd 8568 15 cells cell NNS cord-010119-t1x9gknd 8568 16 ( ( -LRB- cord-010119-t1x9gknd 8568 17 RC RC NNP cord-010119-t1x9gknd 8568 18 ) ) -RRB- cord-010119-t1x9gknd 8568 19 in in IN cord-010119-t1x9gknd 8568 20 2,906 2,906 CD cord-010119-t1x9gknd 8568 21 transfusion transfusion NN cord-010119-t1x9gknd 8568 22 episodes episode NNS cord-010119-t1x9gknd 8568 23 were be VBD cord-010119-t1x9gknd 8568 24 identified identify VBN cord-010119-t1x9gknd 8568 25 . . . cord-010119-t1x9gknd 8569 1 Their -PRON- PRP$ cord-010119-t1x9gknd 8569 2 median median JJ cord-010119-t1x9gknd 8569 3 age age NN cord-010119-t1x9gknd 8569 4 was be VBD cord-010119-t1x9gknd 8569 5 45 45 CD cord-010119-t1x9gknd 8570 1 ( ( -LRB- cord-010119-t1x9gknd 8570 2 range range VB cord-010119-t1x9gknd 8570 3 11 11 CD cord-010119-t1x9gknd 8570 4 -60 -60 NNS cord-010119-t1x9gknd 8570 5 ) ) -RRB- cord-010119-t1x9gknd 8570 6 . . . cord-010119-t1x9gknd 8571 1 The the DT cord-010119-t1x9gknd 8571 2 distribution distribution NN cord-010119-t1x9gknd 8571 3 of of IN cord-010119-t1x9gknd 8571 4 pre pre JJ cord-010119-t1x9gknd 8571 5 - - JJ cord-010119-t1x9gknd 8571 6 and and CC cord-010119-t1x9gknd 8571 7 post post JJ cord-010119-t1x9gknd 8571 8 - - JJ cord-010119-t1x9gknd 8571 9 transfusion transfusion NN cord-010119-t1x9gknd 8571 10 Hb Hb NNP cord-010119-t1x9gknd 8571 11 and and CC cord-010119-t1x9gknd 8571 12 units unit NNS cord-010119-t1x9gknd 8571 13 of of IN cord-010119-t1x9gknd 8571 14 RC RC NNP cord-010119-t1x9gknd 8571 15 transfused transfuse VBN cord-010119-t1x9gknd 8571 16 were be VBD cord-010119-t1x9gknd 8571 17 summarized summarize VBN cord-010119-t1x9gknd 8571 18 below below RB cord-010119-t1x9gknd 8571 19 : : : cord-010119-t1x9gknd 8571 20 In in IN cord-010119-t1x9gknd 8571 21 this this DT cord-010119-t1x9gknd 8571 22 cohort cohort NN cord-010119-t1x9gknd 8571 23 , , , cord-010119-t1x9gknd 8571 24 pre pre VB cord-010119-t1x9gknd 8571 25 - - JJ cord-010119-t1x9gknd 8571 26 and and CC cord-010119-t1x9gknd 8571 27 post post JJ cord-010119-t1x9gknd 8571 28 - - JJ cord-010119-t1x9gknd 8571 29 transfusion transfusion NN cord-010119-t1x9gknd 8571 30 Hb Hb NNP cord-010119-t1x9gknd 8571 31 were be VBD cord-010119-t1x9gknd 8571 32 absent absent JJ cord-010119-t1x9gknd 8571 33 in in IN cord-010119-t1x9gknd 8571 34 46 46 CD cord-010119-t1x9gknd 8571 35 ( ( -LRB- cord-010119-t1x9gknd 8571 36 1.6 1.6 CD cord-010119-t1x9gknd 8571 37 % % NN cord-010119-t1x9gknd 8571 38 ) ) -RRB- cord-010119-t1x9gknd 8571 39 and and CC cord-010119-t1x9gknd 8571 40 283 283 CD cord-010119-t1x9gknd 8571 41 ( ( -LRB- cord-010119-t1x9gknd 8571 42 9.7 9.7 CD cord-010119-t1x9gknd 8571 43 % % NN cord-010119-t1x9gknd 8571 44 ) ) -RRB- cord-010119-t1x9gknd 8571 45 . . . cord-010119-t1x9gknd 8572 1 635 635 CD cord-010119-t1x9gknd 8572 2 ( ( -LRB- cord-010119-t1x9gknd 8572 3 21.9 21.9 CD cord-010119-t1x9gknd 8572 4 % % NN cord-010119-t1x9gknd 8572 5 ) ) -RRB- cord-010119-t1x9gknd 8572 6 transfusion transfusion NN cord-010119-t1x9gknd 8572 7 episodes episode NNS cord-010119-t1x9gknd 8572 8 were be VBD cord-010119-t1x9gknd 8572 9 associated associate VBN cord-010119-t1x9gknd 8572 10 with with IN cord-010119-t1x9gknd 8572 11 the the DT cord-010119-t1x9gknd 8572 12 use use NN cord-010119-t1x9gknd 8572 13 of of IN cord-010119-t1x9gknd 8572 14 3 3 CD cord-010119-t1x9gknd 8572 15 units unit NNS cord-010119-t1x9gknd 8572 16 or or CC cord-010119-t1x9gknd 8572 17 more more JJR cord-010119-t1x9gknd 8572 18 RC rc NN cord-010119-t1x9gknd 8572 19 . . . cord-010119-t1x9gknd 8573 1 As as IN cord-010119-t1x9gknd 8573 2 a a DT cord-010119-t1x9gknd 8573 3 result result NN cord-010119-t1x9gknd 8573 4 , , , cord-010119-t1x9gknd 8573 5 1385 1385 CD cord-010119-t1x9gknd 8573 6 ( ( -LRB- cord-010119-t1x9gknd 8573 7 47.7 47.7 CD cord-010119-t1x9gknd 8573 8 % % NN cord-010119-t1x9gknd 8573 9 ) ) -RRB- cord-010119-t1x9gknd 8573 10 episodes episode NNS cord-010119-t1x9gknd 8573 11 resulted result VBD cord-010119-t1x9gknd 8573 12 in in IN cord-010119-t1x9gknd 8573 13 a a DT cord-010119-t1x9gknd 8573 14 post post JJ cord-010119-t1x9gknd 8573 15 transfusion transfusion NN cord-010119-t1x9gknd 8573 16 Hb Hb NNP cord-010119-t1x9gknd 8573 17 ! ! NNP cord-010119-t1x9gknd 8573 18 9g 9g NNS cord-010119-t1x9gknd 8573 19 / / SYM cord-010119-t1x9gknd 8573 20 dL. dL. NNS cord-010119-t1x9gknd 8573 21 Parenteral Parenteral NNP cord-010119-t1x9gknd 8573 22 iron iron NN cord-010119-t1x9gknd 8573 23 or or CC cord-010119-t1x9gknd 8573 24 tranexamic tranexamic JJ cord-010119-t1x9gknd 8573 25 acid acid NN cord-010119-t1x9gknd 8573 26 was be VBD cord-010119-t1x9gknd 8573 27 uncommon uncommon JJ cord-010119-t1x9gknd 8573 28 during during IN cord-010119-t1x9gknd 8573 29 hospitalization hospitalization NN cord-010119-t1x9gknd 8573 30 and and CC cord-010119-t1x9gknd 8573 31 was be VBD cord-010119-t1x9gknd 8573 32 given give VBN cord-010119-t1x9gknd 8573 33 2 2 CD cord-010119-t1x9gknd 8573 34 ( ( -LRB- cord-010119-t1x9gknd 8573 35 < < XX cord-010119-t1x9gknd 8573 36 0.1 0.1 CD cord-010119-t1x9gknd 8573 37 % % NN cord-010119-t1x9gknd 8573 38 ) ) -RRB- cord-010119-t1x9gknd 8573 39 and and CC cord-010119-t1x9gknd 8573 40 116 116 CD cord-010119-t1x9gknd 8573 41 ( ( -LRB- cord-010119-t1x9gknd 8573 42 4.6 4.6 CD cord-010119-t1x9gknd 8573 43 % % NN cord-010119-t1x9gknd 8573 44 ) ) -RRB- cord-010119-t1x9gknd 8573 45 women woman NNS cord-010119-t1x9gknd 8573 46 respectively respectively RB cord-010119-t1x9gknd 8573 47 . . . cord-010119-t1x9gknd 8574 1 Upon upon IN cord-010119-t1x9gknd 8574 2 discharge discharge NN cord-010119-t1x9gknd 8574 3 , , , cord-010119-t1x9gknd 8574 4 442 442 CD cord-010119-t1x9gknd 8574 5 ( ( -LRB- cord-010119-t1x9gknd 8574 6 15.0 15.0 CD cord-010119-t1x9gknd 8574 7 % % NN cord-010119-t1x9gknd 8574 8 ) ) -RRB- cord-010119-t1x9gknd 8574 9 , , , cord-010119-t1x9gknd 8574 10 84 84 CD cord-010119-t1x9gknd 8574 11 ( ( -LRB- cord-010119-t1x9gknd 8574 12 3.2 3.2 CD cord-010119-t1x9gknd 8574 13 % % NN cord-010119-t1x9gknd 8574 14 ) ) -RRB- cord-010119-t1x9gknd 8574 15 and and CC cord-010119-t1x9gknd 8574 16 1,994 1,994 CD cord-010119-t1x9gknd 8574 17 ( ( -LRB- cord-010119-t1x9gknd 8574 18 65.8 65.8 CD cord-010119-t1x9gknd 8574 19 % % NN cord-010119-t1x9gknd 8574 20 ) ) -RRB- cord-010119-t1x9gknd 8574 21 women woman NNS cord-010119-t1x9gknd 8574 22 were be VBD cord-010119-t1x9gknd 8574 23 prescribed prescribe VBN cord-010119-t1x9gknd 8574 24 with with IN cord-010119-t1x9gknd 8574 25 oral oral JJ cord-010119-t1x9gknd 8574 26 iron iron NN cord-010119-t1x9gknd 8574 27 alone alone RB cord-010119-t1x9gknd 8574 28 , , , cord-010119-t1x9gknd 8574 29 oral oral JJ cord-010119-t1x9gknd 8574 30 tranexamic tranexamic JJ cord-010119-t1x9gknd 8574 31 acid acid NN cord-010119-t1x9gknd 8574 32 alone alone RB cord-010119-t1x9gknd 8574 33 or or CC cord-010119-t1x9gknd 8574 34 both both DT cord-010119-t1x9gknd 8574 35 respectively respectively RB cord-010119-t1x9gknd 8574 36 . . . cord-010119-t1x9gknd 8575 1 However however RB cord-010119-t1x9gknd 8575 2 , , , cord-010119-t1x9gknd 8575 3 neither neither DT cord-010119-t1x9gknd 8575 4 were be VBD cord-010119-t1x9gknd 8575 5 given give VBN cord-010119-t1x9gknd 8575 6 to to IN cord-010119-t1x9gknd 8575 7 386 386 CD cord-010119-t1x9gknd 8575 8 ( ( -LRB- cord-010119-t1x9gknd 8575 9 16.0 16.0 CD cord-010119-t1x9gknd 8575 10 % % NN cord-010119-t1x9gknd 8575 11 ) ) -RRB- cord-010119-t1x9gknd 8575 12 women woman NNS cord-010119-t1x9gknd 8575 13 . . . cord-010119-t1x9gknd 8576 1 Conclusion conclusion NN cord-010119-t1x9gknd 8576 2 : : : cord-010119-t1x9gknd 8577 1 In in IN cord-010119-t1x9gknd 8577 2 the the DT cord-010119-t1x9gknd 8577 3 present present JJ cord-010119-t1x9gknd 8577 4 study study NN cord-010119-t1x9gknd 8577 5 , , , cord-010119-t1x9gknd 8577 6 it -PRON- PRP cord-010119-t1x9gknd 8577 7 is be VBZ cord-010119-t1x9gknd 8577 8 observed observe VBN cord-010119-t1x9gknd 8577 9 that that IN cord-010119-t1x9gknd 8577 10 49.7 49.7 CD cord-010119-t1x9gknd 8577 11 % % NN cord-010119-t1x9gknd 8577 12 transfusion transfusion NN cord-010119-t1x9gknd 8577 13 episodes episode NNS cord-010119-t1x9gknd 8577 14 were be VBD cord-010119-t1x9gknd 8577 15 given give VBN cord-010119-t1x9gknd 8577 16 at at IN cord-010119-t1x9gknd 8577 17 Hb Hb NNP cord-010119-t1x9gknd 8577 18 ! ! . cord-010119-t1x9gknd 8578 1 7g/ 7g/ CD cord-010119-t1x9gknd 8579 1 dL. dL. NNP cord-010119-t1x9gknd 8580 1 A a DT cord-010119-t1x9gknd 8580 2 substantial substantial JJ cord-010119-t1x9gknd 8580 3 number number NN cord-010119-t1x9gknd 8580 4 of of IN cord-010119-t1x9gknd 8580 5 episodes episode NNS cord-010119-t1x9gknd 8580 6 ( ( -LRB- cord-010119-t1x9gknd 8580 7 71.7 71.7 CD cord-010119-t1x9gknd 8580 8 % % NN cord-010119-t1x9gknd 8580 9 ) ) -RRB- cord-010119-t1x9gknd 8580 10 were be VBD cord-010119-t1x9gknd 8580 11 transfused transfuse VBN cord-010119-t1x9gknd 8580 12 with with IN cord-010119-t1x9gknd 8580 13 multiple multiple JJ cord-010119-t1x9gknd 8580 14 units unit NNS cord-010119-t1x9gknd 8580 15 and and CC cord-010119-t1x9gknd 8580 16 resulted result VBD cord-010119-t1x9gknd 8580 17 in in IN cord-010119-t1x9gknd 8580 18 almost almost RB cord-010119-t1x9gknd 8580 19 half half PDT cord-010119-t1x9gknd 8580 20 having have VBG cord-010119-t1x9gknd 8580 21 a a DT cord-010119-t1x9gknd 8580 22 post post JJ cord-010119-t1x9gknd 8580 23 transfusion transfusion NN cord-010119-t1x9gknd 8580 24 Hb Hb NNP cord-010119-t1x9gknd 8580 25 level level NN cord-010119-t1x9gknd 8580 26 ( ( -LRB- cord-010119-t1x9gknd 8580 27 ! ! . cord-010119-t1x9gknd 8581 1 9g 9g NNS cord-010119-t1x9gknd 8581 2 / / SYM cord-010119-t1x9gknd 8581 3 dL dl NN cord-010119-t1x9gknd 8581 4 ) ) -RRB- cord-010119-t1x9gknd 8581 5 . . . cord-010119-t1x9gknd 8582 1 For for IN cord-010119-t1x9gknd 8582 2 iron iron NN cord-010119-t1x9gknd 8582 3 replenishment replenishment NN cord-010119-t1x9gknd 8582 4 and and CC cord-010119-t1x9gknd 8582 5 bleeding bleed VBG cord-010119-t1x9gknd 8582 6 control control NN cord-010119-t1x9gknd 8582 7 , , , cord-010119-t1x9gknd 8582 8 up up IN cord-010119-t1x9gknd 8582 9 to to TO cord-010119-t1x9gknd 8582 10 16.0 16.0 CD cord-010119-t1x9gknd 8582 11 % % NN cord-010119-t1x9gknd 8582 12 transfused transfuse VBN cord-010119-t1x9gknd 8582 13 women woman NNS cord-010119-t1x9gknd 8582 14 were be VBD cord-010119-t1x9gknd 8582 15 not not RB cord-010119-t1x9gknd 8582 16 given give VBN cord-010119-t1x9gknd 8582 17 iron iron NN cord-010119-t1x9gknd 8582 18 or or CC cord-010119-t1x9gknd 8582 19 tranexamic tranexamic JJ cord-010119-t1x9gknd 8582 20 acid acid NN cord-010119-t1x9gknd 8582 21 at at IN cord-010119-t1x9gknd 8582 22 discharge discharge NN cord-010119-t1x9gknd 8582 23 . . . cord-010119-t1x9gknd 8583 1 The the DT cord-010119-t1x9gknd 8583 2 results result NNS cord-010119-t1x9gknd 8583 3 indicate indicate VBP cord-010119-t1x9gknd 8583 4 that that IN cord-010119-t1x9gknd 8583 5 awareness awareness NN cord-010119-t1x9gknd 8583 6 of of IN cord-010119-t1x9gknd 8583 7 both both DT cord-010119-t1x9gknd 8583 8 transfusion transfusion NN cord-010119-t1x9gknd 8583 9 appropriateness appropriateness NN cord-010119-t1x9gknd 8583 10 and and CC cord-010119-t1x9gknd 8583 11 iron iron NN cord-010119-t1x9gknd 8583 12 deficiency deficiency NN cord-010119-t1x9gknd 8583 13 anaemia anaemia NN cord-010119-t1x9gknd 8583 14 management management NN cord-010119-t1x9gknd 8583 15 have have VBP cord-010119-t1x9gknd 8583 16 to to TO cord-010119-t1x9gknd 8583 17 be be VB cord-010119-t1x9gknd 8583 18 improved improve VBN cord-010119-t1x9gknd 8583 19 . . . cord-010119-t1x9gknd 8584 1 It -PRON- PRP cord-010119-t1x9gknd 8584 2 is be VBZ cord-010119-t1x9gknd 8584 3 recommended recommend VBN cord-010119-t1x9gknd 8584 4 that that IN cord-010119-t1x9gknd 8584 5 in in IN cord-010119-t1x9gknd 8584 6 - - HYPH cord-010119-t1x9gknd 8584 7 depth depth NN cord-010119-t1x9gknd 8584 8 education education NN cord-010119-t1x9gknd 8584 9 and and CC cord-010119-t1x9gknd 8584 10 training training NN cord-010119-t1x9gknd 8584 11 should should MD cord-010119-t1x9gknd 8584 12 be be VB cord-010119-t1x9gknd 8584 13 provided provide VBN cord-010119-t1x9gknd 8584 14 for for IN cord-010119-t1x9gknd 8584 15 a a DT cord-010119-t1x9gknd 8584 16 better well RBR cord-010119-t1x9gknd 8584 17 gynaecological gynaecological JJ cord-010119-t1x9gknd 8584 18 patient patient JJ cord-010119-t1x9gknd 8584 19 blood blood NN cord-010119-t1x9gknd 8584 20 management management NN cord-010119-t1x9gknd 8584 21 . . . cord-010119-t1x9gknd 8585 1 Background Background NNP cord-010119-t1x9gknd 8585 2 / / SYM cord-010119-t1x9gknd 8585 3 Case Case NNP cord-010119-t1x9gknd 8585 4 Studies Studies NNPS cord-010119-t1x9gknd 8585 5 : : : cord-010119-t1x9gknd 8585 6 Granulocyte granulocyte NN cord-010119-t1x9gknd 8585 7 transfusions transfusion NNS cord-010119-t1x9gknd 8585 8 may may MD cord-010119-t1x9gknd 8585 9 be be VB cord-010119-t1x9gknd 8585 10 utilized utilize VBN cord-010119-t1x9gknd 8585 11 to to TO cord-010119-t1x9gknd 8585 12 boost boost VB cord-010119-t1x9gknd 8585 13 the the DT cord-010119-t1x9gknd 8585 14 immune immune JJ cord-010119-t1x9gknd 8585 15 response response NN cord-010119-t1x9gknd 8585 16 in in IN cord-010119-t1x9gknd 8585 17 patients patient NNS cord-010119-t1x9gknd 8585 18 with with IN cord-010119-t1x9gknd 8585 19 life life NN cord-010119-t1x9gknd 8585 20 - - HYPH cord-010119-t1x9gknd 8585 21 threatening threaten VBG cord-010119-t1x9gknd 8585 22 neutropenia neutropenia NN cord-010119-t1x9gknd 8585 23 or or CC cord-010119-t1x9gknd 8585 24 neutrophil neutrophil NN cord-010119-t1x9gknd 8585 25 dysfunction dysfunction NN cord-010119-t1x9gknd 8585 26 and and CC cord-010119-t1x9gknd 8585 27 evidence evidence NN cord-010119-t1x9gknd 8585 28 of of IN cord-010119-t1x9gknd 8585 29 treatment treatment NN cord-010119-t1x9gknd 8585 30 - - HYPH cord-010119-t1x9gknd 8585 31 refractory refractory JJ cord-010119-t1x9gknd 8585 32 bacterial bacterial JJ cord-010119-t1x9gknd 8585 33 or or CC cord-010119-t1x9gknd 8585 34 fungal fungal JJ cord-010119-t1x9gknd 8585 35 infection infection NN cord-010119-t1x9gknd 8585 36 . . . cord-010119-t1x9gknd 8586 1 However however RB cord-010119-t1x9gknd 8586 2 , , , cord-010119-t1x9gknd 8586 3 granulocytes granulocyte NNS cord-010119-t1x9gknd 8586 4 are be VBP cord-010119-t1x9gknd 8586 5 rarely rarely RB cord-010119-t1x9gknd 8586 6 administered administer VBN cord-010119-t1x9gknd 8586 7 due due IN cord-010119-t1x9gknd 8586 8 to to IN cord-010119-t1x9gknd 8586 9 uncertainty uncertainty NN cord-010119-t1x9gknd 8586 10 regarding regard VBG cord-010119-t1x9gknd 8586 11 efficacy efficacy NN cord-010119-t1x9gknd 8586 12 , , , cord-010119-t1x9gknd 8586 13 difficulty difficulty NN cord-010119-t1x9gknd 8586 14 in in IN cord-010119-t1x9gknd 8586 15 collection collection NN cord-010119-t1x9gknd 8586 16 , , , cord-010119-t1x9gknd 8586 17 and and CC cord-010119-t1x9gknd 8586 18 increased increase VBN cord-010119-t1x9gknd 8586 19 propensity propensity NN cord-010119-t1x9gknd 8586 20 for for IN cord-010119-t1x9gknd 8586 21 adverse adverse JJ cord-010119-t1x9gknd 8586 22 reactions reaction NNS cord-010119-t1x9gknd 8586 23 . . . cord-010119-t1x9gknd 8587 1 We -PRON- PRP cord-010119-t1x9gknd 8587 2 report report VBP cord-010119-t1x9gknd 8587 3 a a DT cord-010119-t1x9gknd 8587 4 case case NN cord-010119-t1x9gknd 8587 5 of of IN cord-010119-t1x9gknd 8587 6 granulocyte granulocyte NN cord-010119-t1x9gknd 8587 7 transfusion transfusion NN cord-010119-t1x9gknd 8587 8 therapy therapy NN cord-010119-t1x9gknd 8587 9 following follow VBG cord-010119-t1x9gknd 8587 10 chimeric chimeric JJ cord-010119-t1x9gknd 8587 11 antigen antigen NN cord-010119-t1x9gknd 8587 12 receptor receptor NN cord-010119-t1x9gknd 8587 13 T t NN cord-010119-t1x9gknd 8587 14 - - HYPH cord-010119-t1x9gknd 8587 15 cell cell NN cord-010119-t1x9gknd 8587 16 ( ( -LRB- cord-010119-t1x9gknd 8587 17 CAR CAR NNP cord-010119-t1x9gknd 8587 18 - - HYPH cord-010119-t1x9gknd 8587 19 T T NNP cord-010119-t1x9gknd 8587 20 ) ) -RRB- cord-010119-t1x9gknd 8587 21 therapy therapy NN cord-010119-t1x9gknd 8587 22 in in IN cord-010119-t1x9gknd 8587 23 a a DT cord-010119-t1x9gknd 8587 24 patient patient NN cord-010119-t1x9gknd 8587 25 with with IN cord-010119-t1x9gknd 8587 26 severe severe JJ cord-010119-t1x9gknd 8587 27 neutropenia neutropenia NN cord-010119-t1x9gknd 8587 28 and and CC cord-010119-t1x9gknd 8587 29 multiple multiple JJ cord-010119-t1x9gknd 8587 30 infections infection NNS cord-010119-t1x9gknd 8587 31 in in IN cord-010119-t1x9gknd 8587 32 the the DT cord-010119-t1x9gknd 8587 33 context context NN cord-010119-t1x9gknd 8587 34 of of IN cord-010119-t1x9gknd 8587 35 relapsed relapse VBN cord-010119-t1x9gknd 8587 36 B b NN cord-010119-t1x9gknd 8587 37 - - HYPH cord-010119-t1x9gknd 8587 38 cell cell NN cord-010119-t1x9gknd 8587 39 acute acute JJ cord-010119-t1x9gknd 8587 40 lymphoblastic lymphoblastic JJ cord-010119-t1x9gknd 8587 41 leukemia leukemia NN cord-010119-t1x9gknd 8587 42 ( ( -LRB- cord-010119-t1x9gknd 8587 43 B b NN cord-010119-t1x9gknd 8587 44 - - : cord-010119-t1x9gknd 8587 45 ALL ALL NNP cord-010119-t1x9gknd 8587 46 ) ) -RRB- cord-010119-t1x9gknd 8587 47 . . . cord-010119-t1x9gknd 8588 1 Study Study NNP cord-010119-t1x9gknd 8588 2 Design Design NNP cord-010119-t1x9gknd 8588 3 / / SYM cord-010119-t1x9gknd 8588 4 Method method NN cord-010119-t1x9gknd 8588 5 : : : cord-010119-t1x9gknd 8589 1 Granulocytes granulocyte NNS cord-010119-t1x9gknd 8589 2 ( ( -LRB- cord-010119-t1x9gknd 8589 3 0.8 0.8 CD cord-010119-t1x9gknd 8589 4 - - SYM cord-010119-t1x9gknd 8589 5 1.3x10 1.3x10 CD cord-010119-t1x9gknd 8589 6 10 10 CD cord-010119-t1x9gknd 8589 7 per per IN cord-010119-t1x9gknd 8589 8 unit unit NN cord-010119-t1x9gknd 8589 9 ) ) -RRB- cord-010119-t1x9gknd 8589 10 were be VBD cord-010119-t1x9gknd 8589 11 collected collect VBN cord-010119-t1x9gknd 8589 12 from from IN cord-010119-t1x9gknd 8589 13 ABO ABO NNP cord-010119-t1x9gknd 8589 14 - - HYPH cord-010119-t1x9gknd 8589 15 identical identical JJ cord-010119-t1x9gknd 8589 16 unstimulated unstimulated JJ cord-010119-t1x9gknd 8589 17 donors donor NNS cord-010119-t1x9gknd 8589 18 at at IN cord-010119-t1x9gknd 8589 19 a a DT cord-010119-t1x9gknd 8589 20 regional regional JJ cord-010119-t1x9gknd 8589 21 blood blood NN cord-010119-t1x9gknd 8589 22 center center NN cord-010119-t1x9gknd 8589 23 . . . cord-010119-t1x9gknd 8590 1 Each each DT cord-010119-t1x9gknd 8590 2 unit unit NN cord-010119-t1x9gknd 8590 3 was be VBD cord-010119-t1x9gknd 8590 4 irradiated irradiate VBN cord-010119-t1x9gknd 8590 5 with with IN cord-010119-t1x9gknd 8590 6 25 25 CD cord-010119-t1x9gknd 8590 7 Gy Gy NNP cord-010119-t1x9gknd 8590 8 and and CC cord-010119-t1x9gknd 8590 9 transfused transfuse VBN cord-010119-t1x9gknd 8590 10 over over IN cord-010119-t1x9gknd 8590 11 3 3 CD cord-010119-t1x9gknd 8590 12 - - SYM cord-010119-t1x9gknd 8590 13 4 4 CD cord-010119-t1x9gknd 8590 14 hours hour NNS cord-010119-t1x9gknd 8590 15 within within IN cord-010119-t1x9gknd 8590 16 24 24 CD cord-010119-t1x9gknd 8590 17 hours hour NNS cord-010119-t1x9gknd 8590 18 after after IN cord-010119-t1x9gknd 8590 19 the the DT cord-010119-t1x9gknd 8590 20 time time NN cord-010119-t1x9gknd 8590 21 of of IN cord-010119-t1x9gknd 8590 22 collection collection NN cord-010119-t1x9gknd 8590 23 . . . cord-010119-t1x9gknd 8591 1 The the DT cord-010119-t1x9gknd 8591 2 patient patient NN cord-010119-t1x9gknd 8591 3 's 's POS cord-010119-t1x9gknd 8591 4 response response NN cord-010119-t1x9gknd 8591 5 and and CC cord-010119-t1x9gknd 8591 6 laboratory laboratory NN cord-010119-t1x9gknd 8591 7 data datum NNS cord-010119-t1x9gknd 8591 8 were be VBD cord-010119-t1x9gknd 8591 9 reviewed review VBN cord-010119-t1x9gknd 8591 10 in in IN cord-010119-t1x9gknd 8591 11 the the DT cord-010119-t1x9gknd 8591 12 medical medical JJ cord-010119-t1x9gknd 8591 13 record record NN cord-010119-t1x9gknd 8591 14 . . . cord-010119-t1x9gknd 8592 1 Conclusion conclusion NN cord-010119-t1x9gknd 8592 2 : : : cord-010119-t1x9gknd 8593 1 This this DT cord-010119-t1x9gknd 8593 2 data data NN cord-010119-t1x9gknd 8593 3 suggests suggest VBZ cord-010119-t1x9gknd 8593 4 that that IN cord-010119-t1x9gknd 8593 5 a a DT cord-010119-t1x9gknd 8593 6 diagnosis diagnosis NN cord-010119-t1x9gknd 8593 7 of of IN cord-010119-t1x9gknd 8593 8 AML AML NNP cord-010119-t1x9gknd 8593 9 is be VBZ cord-010119-t1x9gknd 8593 10 associated associate VBN cord-010119-t1x9gknd 8593 11 with with IN cord-010119-t1x9gknd 8593 12 anti anti JJ cord-010119-t1x9gknd 8593 13 - - JJ cord-010119-t1x9gknd 8593 14 HLA HLA NNP cord-010119-t1x9gknd 8593 15 antibodies antibody NNS cord-010119-t1x9gknd 8593 16 . . . cord-010119-t1x9gknd 8594 1 An an DT cord-010119-t1x9gknd 8594 2 increased increase VBN cord-010119-t1x9gknd 8594 3 frequency frequency NN cord-010119-t1x9gknd 8594 4 of of IN cord-010119-t1x9gknd 8594 5 blood blood NN cord-010119-t1x9gknd 8594 6 group group NN cord-010119-t1x9gknd 8594 7 A a NN cord-010119-t1x9gknd 8594 8 in in IN cord-010119-t1x9gknd 8594 9 patients patient NNS cord-010119-t1x9gknd 8594 10 with with IN cord-010119-t1x9gknd 8594 11 AML AML NNP cord-010119-t1x9gknd 8594 12 has have VBZ cord-010119-t1x9gknd 8594 13 been be VBN cord-010119-t1x9gknd 8594 14 reported report VBN cord-010119-t1x9gknd 8594 15 , , , cord-010119-t1x9gknd 8594 16 but but CC cord-010119-t1x9gknd 8594 17 here here RB cord-010119-t1x9gknd 8594 18 no no DT cord-010119-t1x9gknd 8594 19 statistically statistically RB cord-010119-t1x9gknd 8594 20 significant significant JJ cord-010119-t1x9gknd 8594 21 difference difference NN cord-010119-t1x9gknd 8594 22 between between IN cord-010119-t1x9gknd 8594 23 ABO ABO NNP cord-010119-t1x9gknd 8594 24 blood blood NN cord-010119-t1x9gknd 8594 25 group group NN cord-010119-t1x9gknd 8594 26 frequencies frequency NNS cord-010119-t1x9gknd 8594 27 was be VBD cord-010119-t1x9gknd 8594 28 found find VBN cord-010119-t1x9gknd 8594 29 in in IN cord-010119-t1x9gknd 8594 30 any any DT cord-010119-t1x9gknd 8594 31 category category NN cord-010119-t1x9gknd 8594 32 except except IN cord-010119-t1x9gknd 8594 33 the the DT cord-010119-t1x9gknd 8594 34 patient patient NN cord-010119-t1x9gknd 8594 35 's 's POS cord-010119-t1x9gknd 8594 36 with with IN cord-010119-t1x9gknd 8594 37 HLA HLA NNP cord-010119-t1x9gknd 8594 38 antibodies antibody NNS cord-010119-t1x9gknd 8594 39 . . . cord-010119-t1x9gknd 8595 1 Blood blood NN cord-010119-t1x9gknd 8595 2 group group NN cord-010119-t1x9gknd 8595 3 B B NNP cord-010119-t1x9gknd 8595 4 has have VBZ cord-010119-t1x9gknd 8595 5 a a DT cord-010119-t1x9gknd 8595 6 significant significant JJ cord-010119-t1x9gknd 8595 7 association association NN cord-010119-t1x9gknd 8595 8 with with IN cord-010119-t1x9gknd 8595 9 HLA HLA NNP cord-010119-t1x9gknd 8595 10 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8595 11 in in IN cord-010119-t1x9gknd 8595 12 the the DT cord-010119-t1x9gknd 8595 13 studied study VBN cord-010119-t1x9gknd 8595 14 patients patient NNS cord-010119-t1x9gknd 8595 15 . . . cord-010119-t1x9gknd 8596 1 It -PRON- PRP cord-010119-t1x9gknd 8596 2 has have VBZ cord-010119-t1x9gknd 8596 3 been be VBN cord-010119-t1x9gknd 8596 4 reported report VBN cord-010119-t1x9gknd 8596 5 in in IN cord-010119-t1x9gknd 8596 6 a a DT cord-010119-t1x9gknd 8596 7 large large JJ cord-010119-t1x9gknd 8596 8 study study NN cord-010119-t1x9gknd 8596 9 of of IN cord-010119-t1x9gknd 8596 10 female female JJ cord-010119-t1x9gknd 8596 11 blood blood NN cord-010119-t1x9gknd 8596 12 donors donor NNS cord-010119-t1x9gknd 8596 13 that that WDT cord-010119-t1x9gknd 8596 14 no no DT cord-010119-t1x9gknd 8596 15 difference difference NN cord-010119-t1x9gknd 8596 16 in in IN cord-010119-t1x9gknd 8596 17 HLA HLA NNP cord-010119-t1x9gknd 8596 18 antibody antibody NN cord-010119-t1x9gknd 8596 19 frequency frequency NN cord-010119-t1x9gknd 8596 20 was be VBD cord-010119-t1x9gknd 8596 21 observed observe VBN cord-010119-t1x9gknd 8596 22 based base VBN cord-010119-t1x9gknd 8596 23 on on IN cord-010119-t1x9gknd 8596 24 ABO ABO NNP cord-010119-t1x9gknd 8596 25 blood blood NN cord-010119-t1x9gknd 8596 26 group group NN cord-010119-t1x9gknd 8596 27 at at IN cord-010119-t1x9gknd 8596 28 centers center NNS cord-010119-t1x9gknd 8596 29 using use VBG cord-010119-t1x9gknd 8596 30 the the DT cord-010119-t1x9gknd 8596 31 flow flow NN cord-010119-t1x9gknd 8596 32 - - HYPH cord-010119-t1x9gknd 8596 33 based base VBN cord-010119-t1x9gknd 8596 34 assay assay NN cord-010119-t1x9gknd 8596 35 . . . cord-010119-t1x9gknd 8597 1 Although although IN cord-010119-t1x9gknd 8597 2 the the DT cord-010119-t1x9gknd 8597 3 reasons reason NNS cord-010119-t1x9gknd 8597 4 for for IN cord-010119-t1x9gknd 8597 5 the the DT cord-010119-t1x9gknd 8597 6 higher high JJR cord-010119-t1x9gknd 8597 7 rate rate NN cord-010119-t1x9gknd 8597 8 of of IN cord-010119-t1x9gknd 8597 9 group group NN cord-010119-t1x9gknd 8597 10 B b NN cord-010119-t1x9gknd 8597 11 blood blood NN cord-010119-t1x9gknd 8597 12 type type NN cord-010119-t1x9gknd 8597 13 among among IN cord-010119-t1x9gknd 8597 14 patients patient NNS cord-010119-t1x9gknd 8597 15 with with IN cord-010119-t1x9gknd 8597 16 anti anti JJ cord-010119-t1x9gknd 8597 17 - - JJ cord-010119-t1x9gknd 8597 18 HLA HLA NNP cord-010119-t1x9gknd 8597 19 antibodies antibody NNS cord-010119-t1x9gknd 8597 20 and and CC cord-010119-t1x9gknd 8597 21 hematologic hematologic JJ cord-010119-t1x9gknd 8597 22 malignancies malignancy NNS cord-010119-t1x9gknd 8597 23 is be VBZ cord-010119-t1x9gknd 8597 24 unknown unknown JJ cord-010119-t1x9gknd 8597 25 , , , cord-010119-t1x9gknd 8597 26 this this DT cord-010119-t1x9gknd 8597 27 could could MD cord-010119-t1x9gknd 8597 28 be be VB cord-010119-t1x9gknd 8597 29 due due JJ cord-010119-t1x9gknd 8597 30 to to IN cord-010119-t1x9gknd 8597 31 variation variation NN cord-010119-t1x9gknd 8597 32 in in IN cord-010119-t1x9gknd 8597 33 immunizing immunize VBG cord-010119-t1x9gknd 8597 34 events event NNS cord-010119-t1x9gknd 8597 35 ( ( -LRB- cord-010119-t1x9gknd 8597 36 pregnancy pregnancy NN cord-010119-t1x9gknd 8597 37 vs vs IN cord-010119-t1x9gknd 8597 38 transfusion transfusion NN cord-010119-t1x9gknd 8597 39 ) ) -RRB- cord-010119-t1x9gknd 8597 40 or or CC cord-010119-t1x9gknd 8597 41 immune immune JJ cord-010119-t1x9gknd 8597 42 dysregulation dysregulation NN cord-010119-t1x9gknd 8597 43 related relate VBN cord-010119-t1x9gknd 8597 44 to to IN cord-010119-t1x9gknd 8597 45 the the DT cord-010119-t1x9gknd 8597 46 hematologic hematologic JJ cord-010119-t1x9gknd 8597 47 malignancy malignancy NN cord-010119-t1x9gknd 8597 48 , , , cord-010119-t1x9gknd 8597 49 especially especially RB cord-010119-t1x9gknd 8597 50 AML AML NNP cord-010119-t1x9gknd 8597 51 . . . cord-010119-t1x9gknd 8598 1 Females female NNS cord-010119-t1x9gknd 8598 2 with with IN cord-010119-t1x9gknd 8598 3 AML AML NNP cord-010119-t1x9gknd 8598 4 who who WP cord-010119-t1x9gknd 8598 5 are be VBP cord-010119-t1x9gknd 8598 6 blood blood NN cord-010119-t1x9gknd 8598 7 group group NN cord-010119-t1x9gknd 8598 8 B B NNP cord-010119-t1x9gknd 8598 9 appear appear VB cord-010119-t1x9gknd 8598 10 to to TO cord-010119-t1x9gknd 8598 11 be be VB cord-010119-t1x9gknd 8598 12 most most RBS cord-010119-t1x9gknd 8598 13 likely likely JJ cord-010119-t1x9gknd 8598 14 to to TO cord-010119-t1x9gknd 8598 15 have have VB cord-010119-t1x9gknd 8598 16 HLA HLA NNP cord-010119-t1x9gknd 8598 17 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8598 18 among among IN cord-010119-t1x9gknd 8598 19 patients patient NNS cord-010119-t1x9gknd 8598 20 with with IN cord-010119-t1x9gknd 8598 21 hematologic hematologic JJ cord-010119-t1x9gknd 8598 22 malignancies malignancy NNS cord-010119-t1x9gknd 8598 23 . . . cord-010119-t1x9gknd 8599 1 Implementation implementation NN cord-010119-t1x9gknd 8599 2 of of IN cord-010119-t1x9gknd 8599 3 Electronic Electronic NNP cord-010119-t1x9gknd 8599 4 Solution Solution NNP cord-010119-t1x9gknd 8599 5 to to TO cord-010119-t1x9gknd 8599 6 Reduce reduce VB cord-010119-t1x9gknd 8599 7 Risk risk NN cord-010119-t1x9gknd 8599 8 of of IN cord-010119-t1x9gknd 8599 9 Mistransfusion Mistransfusion NNP cord-010119-t1x9gknd 8599 10 in in IN cord-010119-t1x9gknd 8599 11 a a DT cord-010119-t1x9gknd 8599 12 Regional Regional NNP cord-010119-t1x9gknd 8599 13 Transfusion Transfusion NNP cord-010119-t1x9gknd 8599 14 Service Service NNP cord-010119-t1x9gknd 8599 15 Debra Debra NNP cord-010119-t1x9gknd 8599 16 Lane Lane NNP cord-010119-t1x9gknd 8600 1 * * NFP cord-010119-t1x9gknd 8600 2 1 1 CD cord-010119-t1x9gknd 8600 3 , , , cord-010119-t1x9gknd 8600 4 Lee Lee NNP cord-010119-t1x9gknd 8600 5 Grabner Grabner NNP cord-010119-t1x9gknd 8600 6 1 1 CD cord-010119-t1x9gknd 8600 7 , , , cord-010119-t1x9gknd 8600 8 Brenda Brenda NNP cord-010119-t1x9gknd 8600 9 Herdman Herdman NNP cord-010119-t1x9gknd 8600 10 2 2 CD cord-010119-t1x9gknd 8600 11 , , , cord-010119-t1x9gknd 8600 12 Robert Robert NNP cord-010119-t1x9gknd 8600 13 Fallis Fallis NNP cord-010119-t1x9gknd 8600 14 1 1 CD cord-010119-t1x9gknd 8600 15 , , , cord-010119-t1x9gknd 8600 16 Amin Amin NNP cord-010119-t1x9gknd 8600 17 Kabani Kabani NNP cord-010119-t1x9gknd 8600 18 3 3 CD cord-010119-t1x9gknd 8600 19 and and CC cord-010119-t1x9gknd 8600 20 Charles Charles NNP cord-010119-t1x9gknd 8600 21 Musuka Musuka NNP cord-010119-t1x9gknd 8600 22 3 3 CD cord-010119-t1x9gknd 8600 23 . . . cord-010119-t1x9gknd 8601 1 1 1 CD cord-010119-t1x9gknd 8601 2 Canadian Canadian NNP cord-010119-t1x9gknd 8601 3 Blood Blood NNP cord-010119-t1x9gknd 8601 4 Services Services NNPS cord-010119-t1x9gknd 8601 5 , , , cord-010119-t1x9gknd 8601 6 2 2 CD cord-010119-t1x9gknd 8601 7 Kenora Kenora NNP cord-010119-t1x9gknd 8601 8 Rainy Rainy NNP cord-010119-t1x9gknd 8601 9 - - HYPH cord-010119-t1x9gknd 8601 10 River River NNP cord-010119-t1x9gknd 8601 11 Regional Regional NNP cord-010119-t1x9gknd 8601 12 Laboratory Laboratory NNP cord-010119-t1x9gknd 8601 13 Program Program NNP cord-010119-t1x9gknd 8601 14 , , , cord-010119-t1x9gknd 8601 15 3 3 CD cord-010119-t1x9gknd 8601 16 Diagnostic Diagnostic NNP cord-010119-t1x9gknd 8601 17 Services Services NNPS cord-010119-t1x9gknd 8601 18 Manitoba Manitoba NNP cord-010119-t1x9gknd 8601 19 Background Background NNP cord-010119-t1x9gknd 8601 20 / / SYM cord-010119-t1x9gknd 8601 21 Case Case NNP cord-010119-t1x9gknd 8601 22 Studies Studies NNPS cord-010119-t1x9gknd 8601 23 : : : cord-010119-t1x9gknd 8601 24 Patient patient JJ cord-010119-t1x9gknd 8601 25 misidentification misidentification NN cord-010119-t1x9gknd 8601 26 and and CC cord-010119-t1x9gknd 8601 27 improper improper JJ cord-010119-t1x9gknd 8601 28 sample sample NN cord-010119-t1x9gknd 8601 29 labeling labeling NN cord-010119-t1x9gknd 8601 30 has have VBZ cord-010119-t1x9gknd 8601 31 been be VBN cord-010119-t1x9gknd 8601 32 an an DT cord-010119-t1x9gknd 8601 33 ongoing ongoing JJ cord-010119-t1x9gknd 8601 34 risk risk NN cord-010119-t1x9gknd 8601 35 for for IN cord-010119-t1x9gknd 8601 36 the the DT cord-010119-t1x9gknd 8601 37 safety safety NN cord-010119-t1x9gknd 8601 38 of of IN cord-010119-t1x9gknd 8601 39 blood blood NN cord-010119-t1x9gknd 8601 40 transfusion transfusion NN cord-010119-t1x9gknd 8601 41 . . . cord-010119-t1x9gknd 8602 1 The the DT cord-010119-t1x9gknd 8602 2 rate rate NN cord-010119-t1x9gknd 8602 3 of of IN cord-010119-t1x9gknd 8602 4 mistransfusion mistransfusion NN cord-010119-t1x9gknd 8602 5 has have VBZ cord-010119-t1x9gknd 8602 6 remained remain VBN cord-010119-t1x9gknd 8602 7 unchanged unchanged JJ cord-010119-t1x9gknd 8602 8 in in IN cord-010119-t1x9gknd 8602 9 over over IN cord-010119-t1x9gknd 8602 10 50 50 CD cord-010119-t1x9gknd 8602 11 years year NNS cord-010119-t1x9gknd 8602 12 . . . cord-010119-t1x9gknd 8603 1 Attempts attempt NNS cord-010119-t1x9gknd 8603 2 have have VBP cord-010119-t1x9gknd 8603 3 been be VBN cord-010119-t1x9gknd 8603 4 made make VBN cord-010119-t1x9gknd 8603 5 to to TO cord-010119-t1x9gknd 8603 6 reduce reduce VB cord-010119-t1x9gknd 8603 7 mistransfusion mistransfusion NN cord-010119-t1x9gknd 8603 8 including include VBG cord-010119-t1x9gknd 8603 9 barrier barrier NN cord-010119-t1x9gknd 8603 10 devices device NNS cord-010119-t1x9gknd 8603 11 , , , cord-010119-t1x9gknd 8603 12 barcoding barcoding NN cord-010119-t1x9gknd 8603 13 and and CC cord-010119-t1x9gknd 8603 14 RFID RFID NNP cord-010119-t1x9gknd 8603 15 . . . cord-010119-t1x9gknd 8604 1 Within within IN cord-010119-t1x9gknd 8604 2 a a DT cord-010119-t1x9gknd 8604 3 Regional Regional NNP cord-010119-t1x9gknd 8604 4 Background Background NNP cord-010119-t1x9gknd 8604 5 / / SYM cord-010119-t1x9gknd 8604 6 Case Case NNP cord-010119-t1x9gknd 8604 7 Studies Studies NNPS cord-010119-t1x9gknd 8604 8 : : : cord-010119-t1x9gknd 8604 9 The the DT cord-010119-t1x9gknd 8604 10 role role NN cord-010119-t1x9gknd 8604 11 of of IN cord-010119-t1x9gknd 8604 12 donor donor NN cord-010119-t1x9gknd 8604 13 age age NN cord-010119-t1x9gknd 8604 14 and and CC cord-010119-t1x9gknd 8604 15 sex sex NN cord-010119-t1x9gknd 8604 16 on on IN cord-010119-t1x9gknd 8604 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8604 18 content content NN cord-010119-t1x9gknd 8604 19 and and CC cord-010119-t1x9gknd 8604 20 susceptibility susceptibility NN cord-010119-t1x9gknd 8604 21 to to IN cord-010119-t1x9gknd 8604 22 hemolysis hemolysis NN cord-010119-t1x9gknd 8604 23 during during IN cord-010119-t1x9gknd 8604 24 storage storage NN cord-010119-t1x9gknd 8604 25 of of IN cord-010119-t1x9gknd 8604 26 red red JJ cord-010119-t1x9gknd 8604 27 blood blood NN cord-010119-t1x9gknd 8604 28 cell cell NN cord-010119-t1x9gknd 8604 29 ( ( -LRB- cord-010119-t1x9gknd 8604 30 RBC RBC NNP cord-010119-t1x9gknd 8604 31 ) ) -RRB- cord-010119-t1x9gknd 8604 32 units unit NNS cord-010119-t1x9gknd 8604 33 is be VBZ cord-010119-t1x9gknd 8604 34 receiving receive VBG cord-010119-t1x9gknd 8604 35 increased increase VBN cord-010119-t1x9gknd 8604 36 attention attention NN cord-010119-t1x9gknd 8604 37 . . . cord-010119-t1x9gknd 8605 1 However however RB cord-010119-t1x9gknd 8605 2 , , , cord-010119-t1x9gknd 8605 3 the the DT cord-010119-t1x9gknd 8605 4 impact impact NN cord-010119-t1x9gknd 8605 5 of of IN cord-010119-t1x9gknd 8605 6 donor donor NN cord-010119-t1x9gknd 8605 7 characteristics characteristic NNS cord-010119-t1x9gknd 8605 8 on on IN cord-010119-t1x9gknd 8605 9 efficacy efficacy NN cord-010119-t1x9gknd 8605 10 of of IN cord-010119-t1x9gknd 8605 11 RBC RBC NNP cord-010119-t1x9gknd 8605 12 transfusion transfusion NN cord-010119-t1x9gknd 8605 13 has have VBZ cord-010119-t1x9gknd 8605 14 not not RB cord-010119-t1x9gknd 8605 15 been be VBN cord-010119-t1x9gknd 8605 16 studied study VBN cord-010119-t1x9gknd 8605 17 in in IN cord-010119-t1x9gknd 8605 18 largescale largescale JJ cord-010119-t1x9gknd 8605 19 donor donor NN cord-010119-t1x9gknd 8605 20 - - HYPH cord-010119-t1x9gknd 8605 21 recipient recipient NN cord-010119-t1x9gknd 8605 22 outcomes outcome NNS cord-010119-t1x9gknd 8605 23 databases database NNS cord-010119-t1x9gknd 8605 24 . . . cord-010119-t1x9gknd 8606 1 Study Study NNP cord-010119-t1x9gknd 8606 2 Design Design NNP cord-010119-t1x9gknd 8606 3 / / SYM cord-010119-t1x9gknd 8606 4 Methods method NNS cord-010119-t1x9gknd 8607 1 : : : cord-010119-t1x9gknd 8607 2 We -PRON- PRP cord-010119-t1x9gknd 8607 3 conducted conduct VBD cord-010119-t1x9gknd 8607 4 an an DT cord-010119-t1x9gknd 8607 5 analysis analysis NN cord-010119-t1x9gknd 8607 6 using use VBG cord-010119-t1x9gknd 8607 7 blood blood NN cord-010119-t1x9gknd 8607 8 donor donor NN cord-010119-t1x9gknd 8607 9 data datum NNS cord-010119-t1x9gknd 8607 10 routinely routinely RB cord-010119-t1x9gknd 8607 11 collected collect VBN cord-010119-t1x9gknd 8607 12 by by IN cord-010119-t1x9gknd 8607 13 a a DT cord-010119-t1x9gknd 8607 14 blood blood NN cord-010119-t1x9gknd 8607 15 center center NN cord-010119-t1x9gknd 8607 16 and and CC cord-010119-t1x9gknd 8607 17 transfusion transfusion NN cord-010119-t1x9gknd 8607 18 recipient recipient NN cord-010119-t1x9gknd 8607 19 data datum NNS cord-010119-t1x9gknd 8607 20 from from IN cord-010119-t1x9gknd 8607 21 a a DT cord-010119-t1x9gknd 8607 22 large large JJ cord-010119-t1x9gknd 8607 23 community community NN cord-010119-t1x9gknd 8607 24 hospital hospital NN cord-010119-t1x9gknd 8607 25 network network NN cord-010119-t1x9gknd 8607 26 between between IN cord-010119-t1x9gknd 8607 27 2008 2008 CD cord-010119-t1x9gknd 8607 28 and and CC cord-010119-t1x9gknd 8607 29 2011 2011 CD cord-010119-t1x9gknd 8607 30 before before IN cord-010119-t1x9gknd 8607 31 patient patient JJ cord-010119-t1x9gknd 8607 32 blood blood NN cord-010119-t1x9gknd 8607 33 management management NN cord-010119-t1x9gknd 8607 34 initiatives initiative NNS cord-010119-t1x9gknd 8607 35 . . . cord-010119-t1x9gknd 8608 1 Linkage linkage NN cord-010119-t1x9gknd 8608 2 was be VBD cord-010119-t1x9gknd 8608 3 performed perform VBN cord-010119-t1x9gknd 8608 4 between between IN cord-010119-t1x9gknd 8608 5 blood blood NN cord-010119-t1x9gknd 8608 6 donor donor NN cord-010119-t1x9gknd 8608 7 characteristics characteristic NNS cord-010119-t1x9gknd 8608 8 and and CC cord-010119-t1x9gknd 8608 9 hospitalized hospitalize VBD cord-010119-t1x9gknd 8608 10 RBC RBC NNP cord-010119-t1x9gknd 8608 11 transfusion transfusion NN cord-010119-t1x9gknd 8608 12 recipients recipient NNS cord-010119-t1x9gknd 8608 13 who who WP cord-010119-t1x9gknd 8608 14 received receive VBD cord-010119-t1x9gknd 8608 15 a a DT cord-010119-t1x9gknd 8608 16 single single JJ cord-010119-t1x9gknd 8608 17 RBC RBC NNP cord-010119-t1x9gknd 8608 18 unit unit NN cord-010119-t1x9gknd 8608 19 . . . cord-010119-t1x9gknd 8609 1 Studied study VBN cord-010119-t1x9gknd 8609 2 exposures exposure NNS cord-010119-t1x9gknd 8609 3 for for IN cord-010119-t1x9gknd 8609 4 this this DT cord-010119-t1x9gknd 8609 5 analysis analysis NN cord-010119-t1x9gknd 8609 6 were be VBD cord-010119-t1x9gknd 8609 7 blood blood NN cord-010119-t1x9gknd 8609 8 donor donor NN cord-010119-t1x9gknd 8609 9 sex sex NN cord-010119-t1x9gknd 8609 10 and and CC cord-010119-t1x9gknd 8609 11 age age NN cord-010119-t1x9gknd 8609 12 in in IN cord-010119-t1x9gknd 8609 13 addition addition NN cord-010119-t1x9gknd 8609 14 to to IN cord-010119-t1x9gknd 8609 15 RBC RBC NNP cord-010119-t1x9gknd 8609 16 storage storage NN cord-010119-t1x9gknd 8609 17 age age NN cord-010119-t1x9gknd 8609 18 . . . cord-010119-t1x9gknd 8610 1 The the DT cord-010119-t1x9gknd 8610 2 Wilcoxon Wilcoxon NNP cord-010119-t1x9gknd 8610 3 test test NN cord-010119-t1x9gknd 8610 4 was be VBD cord-010119-t1x9gknd 8610 5 used use VBN cord-010119-t1x9gknd 8610 6 to to TO cord-010119-t1x9gknd 8610 7 examine examine VB cord-010119-t1x9gknd 8610 8 changes change NNS cord-010119-t1x9gknd 8610 9 in in IN cord-010119-t1x9gknd 8610 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8610 11 level level NN cord-010119-t1x9gknd 8610 12 following follow VBG cord-010119-t1x9gknd 8610 13 RBC RBC NNP cord-010119-t1x9gknd 8610 14 transfusion transfusion NN cord-010119-t1x9gknd 8610 15 , , , cord-010119-t1x9gknd 8610 16 and and CC cord-010119-t1x9gknd 8610 17 , , , cord-010119-t1x9gknd 8610 18 and and CC cord-010119-t1x9gknd 8610 19 38 38 CD cord-010119-t1x9gknd 8610 20 % % NN cord-010119-t1x9gknd 8610 21 were be VBD cord-010119-t1x9gknd 8610 22 male male JJ cord-010119-t1x9gknd 8610 23 . . . cord-010119-t1x9gknd 8611 1 Recipients recipient NNS cord-010119-t1x9gknd 8611 2 of of IN cord-010119-t1x9gknd 8611 3 RBC RBC NNP cord-010119-t1x9gknd 8611 4 's 's POS cord-010119-t1x9gknd 8611 5 from from IN cord-010119-t1x9gknd 8611 6 male male JJ cord-010119-t1x9gknd 8611 7 and and CC cord-010119-t1x9gknd 8611 8 female female JJ cord-010119-t1x9gknd 8611 9 donors donor NNS cord-010119-t1x9gknd 8611 10 had have VBD cord-010119-t1x9gknd 8611 11 similar similar JJ cord-010119-t1x9gknd 8611 12 pre pre JJ cord-010119-t1x9gknd 8611 13 - - JJ cord-010119-t1x9gknd 8611 14 transfusion transfusion JJ cord-010119-t1x9gknd 8611 15 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8611 16 levels level NNS cord-010119-t1x9gknd 8611 17 ( ( -LRB- cord-010119-t1x9gknd 8611 18 8.7 8.7 CD cord-010119-t1x9gknd 8611 19 g g NN cord-010119-t1x9gknd 8611 20 / / SYM cord-010119-t1x9gknd 8611 21 dL dl NN cord-010119-t1x9gknd 8611 22 ; ; : cord-010119-t1x9gknd 8611 23 p50.94 p50.94 NNP cord-010119-t1x9gknd 8611 24 ) ) -RRB- cord-010119-t1x9gknd 8611 25 ; ; : cord-010119-t1x9gknd 8611 26 however however RB cord-010119-t1x9gknd 8611 27 , , , cord-010119-t1x9gknd 8611 28 transfusion transfusion NN cord-010119-t1x9gknd 8611 29 recipients recipient NNS cord-010119-t1x9gknd 8611 30 of of IN cord-010119-t1x9gknd 8611 31 male male JJ cord-010119-t1x9gknd 8611 32 donor donor NN cord-010119-t1x9gknd 8611 33 RBC RBC NNP cord-010119-t1x9gknd 8611 34 units unit NNS cord-010119-t1x9gknd 8611 35 had have VBD cord-010119-t1x9gknd 8611 36 higher high JJR cord-010119-t1x9gknd 8611 37 post post JJ cord-010119-t1x9gknd 8611 38 - - JJ cord-010119-t1x9gknd 8611 39 transfusion transfusion JJ cord-010119-t1x9gknd 8611 40 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8611 41 levels level NNS cord-010119-t1x9gknd 8611 42 and and CC cord-010119-t1x9gknd 8611 43 larger large JJR cord-010119-t1x9gknd 8611 44 increments increment NNS cord-010119-t1x9gknd 8611 45 in in IN cord-010119-t1x9gknd 8611 46 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8611 47 compared compare VBN cord-010119-t1x9gknd 8611 48 to to IN cord-010119-t1x9gknd 8611 49 those those DT cord-010119-t1x9gknd 8611 50 of of IN cord-010119-t1x9gknd 8611 51 female female JJ cord-010119-t1x9gknd 8611 52 RBC RBC NNP cord-010119-t1x9gknd 8611 53 units unit NNS cord-010119-t1x9gknd 8611 54 ( ( -LRB- cord-010119-t1x9gknd 8611 55 9.9 9.9 CD cord-010119-t1x9gknd 8611 56 vs vs IN cord-010119-t1x9gknd 8611 57 9.8 9.8 CD cord-010119-t1x9gknd 8611 58 g g NN cord-010119-t1x9gknd 8611 59 / / SYM cord-010119-t1x9gknd 8611 60 dL dl NN cord-010119-t1x9gknd 8611 61 ; ; : cord-010119-t1x9gknd 8611 62 1.2 1.2 CD cord-010119-t1x9gknd 8611 63 vs. vs. CC cord-010119-t1x9gknd 8611 64 1.1 1.1 CD cord-010119-t1x9gknd 8611 65 g g NN cord-010119-t1x9gknd 8611 66 / / SYM cord-010119-t1x9gknd 8611 67 dL dl NN cord-010119-t1x9gknd 8611 68 ; ; : cord-010119-t1x9gknd 8611 69 both both DT cord-010119-t1x9gknd 8611 70 p50.02 p50.02 NN cord-010119-t1x9gknd 8611 71 ) ) -RRB- cord-010119-t1x9gknd 8611 72 . . . cord-010119-t1x9gknd 8612 1 Female female JJ cord-010119-t1x9gknd 8612 2 recipients recipient NNS cord-010119-t1x9gknd 8612 3 had have VBD cord-010119-t1x9gknd 8612 4 a a DT cord-010119-t1x9gknd 8612 5 larger large JJR cord-010119-t1x9gknd 8612 6 rise rise NN cord-010119-t1x9gknd 8612 7 in in IN cord-010119-t1x9gknd 8612 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8612 9 per per IN cord-010119-t1x9gknd 8612 10 RBC RBC NNP cord-010119-t1x9gknd 8612 11 unit unit NN cord-010119-t1x9gknd 8612 12 compared compare VBN cord-010119-t1x9gknd 8612 13 to to IN cord-010119-t1x9gknd 8612 14 male male JJ cord-010119-t1x9gknd 8612 15 recipients recipient NNS cord-010119-t1x9gknd 8612 16 ( ( -LRB- cord-010119-t1x9gknd 8612 17 1.3 1.3 CD cord-010119-t1x9gknd 8612 18 g g NN cord-010119-t1x9gknd 8612 19 / / SYM cord-010119-t1x9gknd 8612 20 dL dl NN cord-010119-t1x9gknd 8612 21 vs. vs. FW cord-010119-t1x9gknd 8612 22 1.0 1.0 CD cord-010119-t1x9gknd 8612 23 g g NN cord-010119-t1x9gknd 8612 24 / / SYM cord-010119-t1x9gknd 8612 25 dL dl NN cord-010119-t1x9gknd 8612 26 ; ; : cord-010119-t1x9gknd 8612 27 p<0.001 p<0.001 CD cord-010119-t1x9gknd 8612 28 ) ) -RRB- cord-010119-t1x9gknd 8612 29 . . . cord-010119-t1x9gknd 8613 1 Female female JJ cord-010119-t1x9gknd 8613 2 sex sex NN cord-010119-t1x9gknd 8613 3 of of IN cord-010119-t1x9gknd 8613 4 the the DT cord-010119-t1x9gknd 8613 5 recipient recipient NN cord-010119-t1x9gknd 8613 6 remained remain VBD cord-010119-t1x9gknd 8613 7 a a DT cord-010119-t1x9gknd 8613 8 significant significant JJ cord-010119-t1x9gknd 8613 9 predictor predictor NN cord-010119-t1x9gknd 8613 10 of of IN cord-010119-t1x9gknd 8613 11 change change NN cord-010119-t1x9gknd 8613 12 in in IN cord-010119-t1x9gknd 8613 13 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8613 14 after after IN cord-010119-t1x9gknd 8613 15 accounting account VBG cord-010119-t1x9gknd 8613 16 for for IN cord-010119-t1x9gknd 8613 17 recipient recipient NN cord-010119-t1x9gknd 8613 18 age age NN cord-010119-t1x9gknd 8613 19 and and CC cord-010119-t1x9gknd 8613 20 estimated estimate VBD cord-010119-t1x9gknd 8613 21 circulating circulate VBG cord-010119-t1x9gknd 8613 22 blood blood NN cord-010119-t1x9gknd 8613 23 volume volume NN cord-010119-t1x9gknd 8613 24 in in IN cord-010119-t1x9gknd 8613 25 multivariable multivariable JJ cord-010119-t1x9gknd 8613 26 analysis analysis NN cord-010119-t1x9gknd 8613 27 ( ( -LRB- cord-010119-t1x9gknd 8613 28 p50.01 p50.01 NNP cord-010119-t1x9gknd 8613 29 ) ) -RRB- cord-010119-t1x9gknd 8613 30 . . . cord-010119-t1x9gknd 8614 1 RBC RBC NNP cord-010119-t1x9gknd 8614 2 storage storage NN cord-010119-t1x9gknd 8614 3 age age NN cord-010119-t1x9gknd 8614 4 and and CC cord-010119-t1x9gknd 8614 5 the the DT cord-010119-t1x9gknd 8614 6 age age NN cord-010119-t1x9gknd 8614 7 of of IN cord-010119-t1x9gknd 8614 8 the the DT cord-010119-t1x9gknd 8614 9 donor donor NN cord-010119-t1x9gknd 8614 10 were be VBD cord-010119-t1x9gknd 8614 11 not not RB cord-010119-t1x9gknd 8614 12 significant significant JJ cord-010119-t1x9gknd 8614 13 factors factor NNS cord-010119-t1x9gknd 8614 14 in in IN cord-010119-t1x9gknd 8614 15 changes change NNS cord-010119-t1x9gknd 8614 16 in in IN cord-010119-t1x9gknd 8614 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8614 18 levels level NNS cord-010119-t1x9gknd 8614 19 in in IN cord-010119-t1x9gknd 8614 20 multivariable multivariable JJ cord-010119-t1x9gknd 8614 21 analysis analysis NN cord-010119-t1x9gknd 8614 22 , , , cord-010119-t1x9gknd 8614 23 p50.53 p50.53 NNP cord-010119-t1x9gknd 8614 24 and and CC cord-010119-t1x9gknd 8614 25 p50.32 p50.32 NNS cord-010119-t1x9gknd 8614 26 , , , cord-010119-t1x9gknd 8614 27 respectively respectively RB cord-010119-t1x9gknd 8614 28 . . . cord-010119-t1x9gknd 8615 1 Conclusion conclusion NN cord-010119-t1x9gknd 8615 2 : : : cord-010119-t1x9gknd 8615 3 RBC RBC NNP cord-010119-t1x9gknd 8615 4 units unit NNS cord-010119-t1x9gknd 8615 5 from from IN cord-010119-t1x9gknd 8615 6 male male JJ cord-010119-t1x9gknd 8615 7 donors donor NNS cord-010119-t1x9gknd 8615 8 resulted result VBD cord-010119-t1x9gknd 8615 9 in in IN cord-010119-t1x9gknd 8615 10 a a DT cord-010119-t1x9gknd 8615 11 larger large JJR cord-010119-t1x9gknd 8615 12 rise rise NN cord-010119-t1x9gknd 8615 13 in in IN cord-010119-t1x9gknd 8615 14 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8615 15 levels level NNS cord-010119-t1x9gknd 8615 16 compared compare VBN cord-010119-t1x9gknd 8615 17 to to IN cord-010119-t1x9gknd 8615 18 those those DT cord-010119-t1x9gknd 8615 19 from from IN cord-010119-t1x9gknd 8615 20 female female JJ cord-010119-t1x9gknd 8615 21 donors donor NNS cord-010119-t1x9gknd 8615 22 , , , cord-010119-t1x9gknd 8615 23 and and CC cord-010119-t1x9gknd 8615 24 these these DT cord-010119-t1x9gknd 8615 25 changes change NNS cord-010119-t1x9gknd 8615 26 were be VBD cord-010119-t1x9gknd 8615 27 more more RBR cord-010119-t1x9gknd 8615 28 apparent apparent JJ cord-010119-t1x9gknd 8615 29 in in IN cord-010119-t1x9gknd 8615 30 female female JJ cord-010119-t1x9gknd 8615 31 recipients recipient NNS cord-010119-t1x9gknd 8615 32 even even RB cord-010119-t1x9gknd 8615 33 after after IN cord-010119-t1x9gknd 8615 34 accounting account VBG cord-010119-t1x9gknd 8615 35 for for IN cord-010119-t1x9gknd 8615 36 effective effective JJ cord-010119-t1x9gknd 8615 37 circulating circulate VBG cord-010119-t1x9gknd 8615 38 blood blood NN cord-010119-t1x9gknd 8615 39 volumes volume NNS cord-010119-t1x9gknd 8615 40 . . . cord-010119-t1x9gknd 8616 1 This this DT cord-010119-t1x9gknd 8616 2 suggests suggest VBZ cord-010119-t1x9gknd 8616 3 that that IN cord-010119-t1x9gknd 8616 4 the the DT cord-010119-t1x9gknd 8616 5 dose dose NN cord-010119-t1x9gknd 8616 6 of of IN cord-010119-t1x9gknd 8616 7 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8616 8 is be VBZ cord-010119-t1x9gknd 8616 9 lower low JJR cord-010119-t1x9gknd 8616 10 in in IN cord-010119-t1x9gknd 8616 11 female female NN cord-010119-t1x9gknd 8616 12 than than IN cord-010119-t1x9gknd 8616 13 male male JJ cord-010119-t1x9gknd 8616 14 RBC RBC NNP cord-010119-t1x9gknd 8616 15 units unit NNS cord-010119-t1x9gknd 8616 16 . . . cord-010119-t1x9gknd 8617 1 This this DT cord-010119-t1x9gknd 8617 2 analysis analysis NN cord-010119-t1x9gknd 8617 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 8617 4 the the DT cord-010119-t1x9gknd 8617 5 feasibility feasibility NN cord-010119-t1x9gknd 8617 6 of of IN cord-010119-t1x9gknd 8617 7 using use VBG cord-010119-t1x9gknd 8617 8 this this DT cord-010119-t1x9gknd 8617 9 approach approach NN cord-010119-t1x9gknd 8617 10 to to TO cord-010119-t1x9gknd 8617 11 study study VB cord-010119-t1x9gknd 8617 12 the the DT cord-010119-t1x9gknd 8617 13 association association NN cord-010119-t1x9gknd 8617 14 between between IN cord-010119-t1x9gknd 8617 15 donor donor NN cord-010119-t1x9gknd 8617 16 characteristics characteristic NNS cord-010119-t1x9gknd 8617 17 and and CC cord-010119-t1x9gknd 8617 18 RBC RBC NNP cord-010119-t1x9gknd 8617 19 efficacy efficacy NN cord-010119-t1x9gknd 8617 20 , , , cord-010119-t1x9gknd 8617 21 hemolysis hemolysis NN cord-010119-t1x9gknd 8617 22 and and CC cord-010119-t1x9gknd 8617 23 other other JJ cord-010119-t1x9gknd 8617 24 donor donor NN cord-010119-t1x9gknd 8617 25 - - HYPH cord-010119-t1x9gknd 8617 26 component component NN cord-010119-t1x9gknd 8617 27 - - HYPH cord-010119-t1x9gknd 8617 28 recipient recipient NN cord-010119-t1x9gknd 8617 29 interactions interaction NNS cord-010119-t1x9gknd 8617 30 . . . cord-010119-t1x9gknd 8618 1 Background Background NNP cord-010119-t1x9gknd 8618 2 / / SYM cord-010119-t1x9gknd 8618 3 Case Case NNP cord-010119-t1x9gknd 8618 4 Studies Studies NNPS cord-010119-t1x9gknd 8618 5 : : : cord-010119-t1x9gknd 8619 1 People People NNS cord-010119-t1x9gknd 8619 2 who who WP cord-010119-t1x9gknd 8619 3 identify identify VBP cord-010119-t1x9gknd 8619 4 as as IN cord-010119-t1x9gknd 8619 5 Jehovah Jehovah NNP cord-010119-t1x9gknd 8619 6 's 's POS cord-010119-t1x9gknd 8619 7 Witnesses witness NNS cord-010119-t1x9gknd 8619 8 ( ( -LRB- cord-010119-t1x9gknd 8619 9 JW JW NNP cord-010119-t1x9gknd 8619 10 ) ) -RRB- cord-010119-t1x9gknd 8619 11 comprise comprise VBP cord-010119-t1x9gknd 8619 12 less less JJR cord-010119-t1x9gknd 8619 13 than than IN cord-010119-t1x9gknd 8619 14 1 1 CD cord-010119-t1x9gknd 8619 15 % % NN cord-010119-t1x9gknd 8619 16 of of IN cord-010119-t1x9gknd 8619 17 the the DT cord-010119-t1x9gknd 8619 18 population population NN cord-010119-t1x9gknd 8619 19 of of IN cord-010119-t1x9gknd 8619 20 the the DT cord-010119-t1x9gknd 8619 21 United United NNP cord-010119-t1x9gknd 8619 22 States States NNP cord-010119-t1x9gknd 8619 23 . . . cord-010119-t1x9gknd 8620 1 However however RB cord-010119-t1x9gknd 8620 2 , , , cord-010119-t1x9gknd 8620 3 as as IN cord-010119-t1x9gknd 8620 4 a a DT cord-010119-t1x9gknd 8620 5 group group NN cord-010119-t1x9gknd 8620 6 they -PRON- PRP cord-010119-t1x9gknd 8620 7 can can MD cord-010119-t1x9gknd 8620 8 present present VB cord-010119-t1x9gknd 8620 9 a a DT cord-010119-t1x9gknd 8620 10 special special JJ cord-010119-t1x9gknd 8620 11 challenge challenge NN cord-010119-t1x9gknd 8620 12 in in IN cord-010119-t1x9gknd 8620 13 medicine medicine NN cord-010119-t1x9gknd 8620 14 due due IN cord-010119-t1x9gknd 8620 15 to to IN cord-010119-t1x9gknd 8620 16 a a DT cord-010119-t1x9gknd 8620 17 religious religious JJ cord-010119-t1x9gknd 8620 18 aversion aversion NN cord-010119-t1x9gknd 8620 19 to to IN cord-010119-t1x9gknd 8620 20 blood blood NN cord-010119-t1x9gknd 8620 21 products product NNS cord-010119-t1x9gknd 8620 22 , , , cord-010119-t1x9gknd 8620 23 based base VBN cord-010119-t1x9gknd 8620 24 on on IN cord-010119-t1x9gknd 8620 25 biblical biblical JJ cord-010119-t1x9gknd 8620 26 readings reading NNS cord-010119-t1x9gknd 8620 27 . . . cord-010119-t1x9gknd 8621 1 The the DT cord-010119-t1x9gknd 8621 2 degree degree NN cord-010119-t1x9gknd 8621 3 of of IN cord-010119-t1x9gknd 8621 4 this this DT cord-010119-t1x9gknd 8621 5 religious religious JJ cord-010119-t1x9gknd 8621 6 refusal refusal NN cord-010119-t1x9gknd 8621 7 can can MD cord-010119-t1x9gknd 8621 8 vary vary VB cord-010119-t1x9gknd 8621 9 from from IN cord-010119-t1x9gknd 8621 10 individual individual JJ cord-010119-t1x9gknd 8621 11 to to IN cord-010119-t1x9gknd 8621 12 individual individual JJ cord-010119-t1x9gknd 8621 13 , , , cord-010119-t1x9gknd 8621 14 but but CC cord-010119-t1x9gknd 8621 15 as as IN cord-010119-t1x9gknd 8621 16 institutional institutional JJ cord-010119-t1x9gknd 8621 17 policy policy NN cord-010119-t1x9gknd 8621 18 , , , cord-010119-t1x9gknd 8621 19 a a DT cord-010119-t1x9gknd 8621 20 conservative conservative JJ cord-010119-t1x9gknd 8621 21 approach approach NN cord-010119-t1x9gknd 8621 22 is be VBZ cord-010119-t1x9gknd 8621 23 warranted warrant VBN cord-010119-t1x9gknd 8621 24 . . . cord-010119-t1x9gknd 8622 1 However however RB cord-010119-t1x9gknd 8622 2 , , , cord-010119-t1x9gknd 8622 3 in in IN cord-010119-t1x9gknd 8622 4 large large JJ cord-010119-t1x9gknd 8622 5 institutions institution NNS cord-010119-t1x9gknd 8622 6 where where WRB cord-010119-t1x9gknd 8622 7 multiple multiple JJ cord-010119-t1x9gknd 8622 8 teams team NNS cord-010119-t1x9gknd 8622 9 manage manage VBP cord-010119-t1x9gknd 8622 10 a a DT cord-010119-t1x9gknd 8622 11 single single JJ cord-010119-t1x9gknd 8622 12 patient patient NN cord-010119-t1x9gknd 8622 13 , , , cord-010119-t1x9gknd 8622 14 blood blood NN cord-010119-t1x9gknd 8622 15 refusal refusal NN cord-010119-t1x9gknd 8622 16 information information NN cord-010119-t1x9gknd 8622 17 can can MD cord-010119-t1x9gknd 8622 18 be be VB cord-010119-t1x9gknd 8622 19 lost lose VBN cord-010119-t1x9gknd 8622 20 or or CC cord-010119-t1x9gknd 8622 21 poorly poorly RB cord-010119-t1x9gknd 8622 22 communicated communicate VBN cord-010119-t1x9gknd 8622 23 from from IN cord-010119-t1x9gknd 8622 24 provider provider NN cord-010119-t1x9gknd 8622 25 to to IN cord-010119-t1x9gknd 8622 26 provider provider NN cord-010119-t1x9gknd 8622 27 . . . cord-010119-t1x9gknd 8623 1 As as IN cord-010119-t1x9gknd 8623 2 such such JJ cord-010119-t1x9gknd 8623 3 , , , cord-010119-t1x9gknd 8623 4 a a DT cord-010119-t1x9gknd 8623 5 system system NN cord-010119-t1x9gknd 8623 6 to to TO cord-010119-t1x9gknd 8623 7 alert alert VB cord-010119-t1x9gknd 8623 8 providers provider NNS cord-010119-t1x9gknd 8623 9 of of IN cord-010119-t1x9gknd 8623 10 patient patient JJ cord-010119-t1x9gknd 8623 11 blood blood NN cord-010119-t1x9gknd 8623 12 refusal refusal NN cord-010119-t1x9gknd 8623 13 was be VBD cord-010119-t1x9gknd 8623 14 recently recently RB cord-010119-t1x9gknd 8623 15 implemented implement VBN cord-010119-t1x9gknd 8623 16 through through IN cord-010119-t1x9gknd 8623 17 the the DT cord-010119-t1x9gknd 8623 18 electronic electronic JJ cord-010119-t1x9gknd 8623 19 medical medical JJ cord-010119-t1x9gknd 8623 20 record record NN cord-010119-t1x9gknd 8623 21 in in IN cord-010119-t1x9gknd 8623 22 a a DT cord-010119-t1x9gknd 8623 23 large large JJ cord-010119-t1x9gknd 8623 24 west west JJ cord-010119-t1x9gknd 8623 25 - - HYPH cord-010119-t1x9gknd 8623 26 coast coast NN cord-010119-t1x9gknd 8623 27 institution institution NN cord-010119-t1x9gknd 8623 28 . . . cord-010119-t1x9gknd 8624 1 Study Study NNP cord-010119-t1x9gknd 8624 2 Design Design NNP cord-010119-t1x9gknd 8624 3 / / SYM cord-010119-t1x9gknd 8624 4 Method method NN cord-010119-t1x9gknd 8624 5 : : : cord-010119-t1x9gknd 8625 1 The the DT cord-010119-t1x9gknd 8625 2 electronic electronic JJ cord-010119-t1x9gknd 8625 3 medical medical JJ cord-010119-t1x9gknd 8625 4 record record NN cord-010119-t1x9gknd 8625 5 ( ( -LRB- cord-010119-t1x9gknd 8625 6 EMR EMR NNP cord-010119-t1x9gknd 8625 7 ) ) -RRB- cord-010119-t1x9gknd 8625 8 utilized utilize VBN cord-010119-t1x9gknd 8625 9 in in IN cord-010119-t1x9gknd 8625 10 this this DT cord-010119-t1x9gknd 8625 11 study study NN cord-010119-t1x9gknd 8625 12 in in IN cord-010119-t1x9gknd 8625 13 an an DT cord-010119-t1x9gknd 8625 14 institutionally institutionally RB cord-010119-t1x9gknd 8625 15 modified modify VBN cord-010119-t1x9gknd 8625 16 version version NN cord-010119-t1x9gknd 8625 17 of of IN cord-010119-t1x9gknd 8625 18 EPIC EPIC NNP cord-010119-t1x9gknd 8625 19 EA EA NNP cord-010119-t1x9gknd 8625 20 Best Best NNP cord-010119-t1x9gknd 8625 21 Practices Practices NNP cord-010119-t1x9gknd 8625 22 Alert Alert NNP cord-010119-t1x9gknd 8625 23 ( ( -LRB- cord-010119-t1x9gknd 8625 24 BPA BPA NNP cord-010119-t1x9gknd 8625 25 ) ) -RRB- cord-010119-t1x9gknd 8625 26 was be VBD cord-010119-t1x9gknd 8625 27 designed design VBN cord-010119-t1x9gknd 8625 28 to to TO cord-010119-t1x9gknd 8625 29 trigger trigger VB cord-010119-t1x9gknd 8625 30 each each DT cord-010119-t1x9gknd 8625 31 time time NN cord-010119-t1x9gknd 8625 32 an an DT cord-010119-t1x9gknd 8625 33 end end NN cord-010119-t1x9gknd 8625 34 user user NN cord-010119-t1x9gknd 8625 35 attempted attempt VBD cord-010119-t1x9gknd 8625 36 to to TO cord-010119-t1x9gknd 8625 37 place place VB cord-010119-t1x9gknd 8625 38 orders order NNS cord-010119-t1x9gknd 8625 39 related relate VBN cord-010119-t1x9gknd 8625 40 to to IN cord-010119-t1x9gknd 8625 41 blood blood NN cord-010119-t1x9gknd 8625 42 transfusion transfusion NN cord-010119-t1x9gknd 8625 43 , , , cord-010119-t1x9gknd 8625 44 transfusion transfusion NN cord-010119-t1x9gknd 8625 45 - - HYPH cord-010119-t1x9gknd 8625 46 related relate VBN cord-010119-t1x9gknd 8625 47 lab lab NN cord-010119-t1x9gknd 8625 48 testing testing NN cord-010119-t1x9gknd 8625 49 , , , cord-010119-t1x9gknd 8625 50 or or CC cord-010119-t1x9gknd 8625 51 human human NN cord-010119-t1x9gknd 8625 52 - - HYPH cord-010119-t1x9gknd 8625 53 derived derive VBN cord-010119-t1x9gknd 8625 54 pharmacy pharmacy NN cord-010119-t1x9gknd 8625 55 items item NNS cord-010119-t1x9gknd 8625 56 on on IN cord-010119-t1x9gknd 8625 57 patients patient NNS cord-010119-t1x9gknd 8625 58 with with IN cord-010119-t1x9gknd 8625 59 blood blood NN cord-010119-t1x9gknd 8625 60 refusal refusal NN cord-010119-t1x9gknd 8625 61 codes code NNS cord-010119-t1x9gknd 8625 62 in in IN cord-010119-t1x9gknd 8625 63 their -PRON- PRP$ cord-010119-t1x9gknd 8625 64 history history NN cord-010119-t1x9gknd 8625 65 , , , cord-010119-t1x9gknd 8625 66 problem problem NN cord-010119-t1x9gknd 8625 67 list list NN cord-010119-t1x9gknd 8625 68 , , , cord-010119-t1x9gknd 8625 69 or or CC cord-010119-t1x9gknd 8625 70 religion religion NN cord-010119-t1x9gknd 8625 71 ( ( -LRB- cord-010119-t1x9gknd 8625 72 Jehovah Jehovah NNP cord-010119-t1x9gknd 8625 73 's 's POS cord-010119-t1x9gknd 8625 74 Witness Witness NNP cord-010119-t1x9gknd 8625 75 ) ) -RRB- cord-010119-t1x9gknd 8625 76 discrete discrete JJ cord-010119-t1x9gknd 8625 77 data datum NNS cord-010119-t1x9gknd 8625 78 fields field NNS cord-010119-t1x9gknd 8625 79 . . . cord-010119-t1x9gknd 8626 1 The the DT cord-010119-t1x9gknd 8626 2 alert alert NN cord-010119-t1x9gknd 8626 3 constitutes constitute VBZ cord-010119-t1x9gknd 8626 4 a a DT cord-010119-t1x9gknd 8626 5 " " `` cord-010119-t1x9gknd 8626 6 soft soft JJ cord-010119-t1x9gknd 8626 7 - - HYPH cord-010119-t1x9gknd 8626 8 stop stop NN cord-010119-t1x9gknd 8626 9 " " '' cord-010119-t1x9gknd 8626 10 in in IN cord-010119-t1x9gknd 8626 11 which which WDT cord-010119-t1x9gknd 8626 12 the the DT cord-010119-t1x9gknd 8626 13 ordering ordering NN cord-010119-t1x9gknd 8626 14 provided provide VBN cord-010119-t1x9gknd 8626 15 is be VBZ cord-010119-t1x9gknd 8626 16 prompted prompt VBN cord-010119-t1x9gknd 8626 17 to to TO cord-010119-t1x9gknd 8626 18 either either CC cord-010119-t1x9gknd 8626 19 cancel cancel VB cord-010119-t1x9gknd 8626 20 the the DT cord-010119-t1x9gknd 8626 21 triggering trigger VBG cord-010119-t1x9gknd 8626 22 orders order NNS cord-010119-t1x9gknd 8626 23 or or CC cord-010119-t1x9gknd 8626 24 acknowledge acknowledge VB cord-010119-t1x9gknd 8626 25 the the DT cord-010119-t1x9gknd 8626 26 blood blood NN cord-010119-t1x9gknd 8626 27 refusal refusal NN cord-010119-t1x9gknd 8626 28 / / SYM cord-010119-t1x9gknd 8626 29 religious religious JJ cord-010119-t1x9gknd 8626 30 history history NN cord-010119-t1x9gknd 8626 31 and and CC cord-010119-t1x9gknd 8626 32 override override VB cord-010119-t1x9gknd 8626 33 the the DT cord-010119-t1x9gknd 8626 34 warning warning NN cord-010119-t1x9gknd 8626 35 with with IN cord-010119-t1x9gknd 8626 36 an an DT cord-010119-t1x9gknd 8626 37 option option NN cord-010119-t1x9gknd 8626 38 to to TO cord-010119-t1x9gknd 8626 39 select select VB cord-010119-t1x9gknd 8626 40 a a DT cord-010119-t1x9gknd 8626 41 reason reason NN cord-010119-t1x9gknd 8626 42 for for IN cord-010119-t1x9gknd 8626 43 the the DT cord-010119-t1x9gknd 8626 44 override override NN cord-010119-t1x9gknd 8626 45 . . . cord-010119-t1x9gknd 8627 1 Data datum NNS cord-010119-t1x9gknd 8627 2 on on IN cord-010119-t1x9gknd 8627 3 the the DT cord-010119-t1x9gknd 8627 4 triggers trigger NNS cord-010119-t1x9gknd 8627 5 are be VBP cord-010119-t1x9gknd 8627 6 automatically automatically RB cord-010119-t1x9gknd 8627 7 collected collect VBN cord-010119-t1x9gknd 8627 8 through through IN cord-010119-t1x9gknd 8627 9 the the DT cord-010119-t1x9gknd 8627 10 EMR EMR NNP cord-010119-t1x9gknd 8627 11 systems system NNS cord-010119-t1x9gknd 8627 12 and and CC cord-010119-t1x9gknd 8627 13 generated generate VBN cord-010119-t1x9gknd 8627 14 into into IN cord-010119-t1x9gknd 8627 15 a a DT cord-010119-t1x9gknd 8627 16 report report NN cord-010119-t1x9gknd 8627 17 by by IN cord-010119-t1x9gknd 8627 18 informatics informatics NN cord-010119-t1x9gknd 8627 19 personnel personnel NNS cord-010119-t1x9gknd 8627 20 . . . cord-010119-t1x9gknd 8628 1 Results/ Results/ . cord-010119-t1x9gknd 8629 1 Finding finding NN cord-010119-t1x9gknd 8629 2 : : : cord-010119-t1x9gknd 8630 1 The the DT cord-010119-t1x9gknd 8630 2 available available JJ cord-010119-t1x9gknd 8630 3 data datum NNS cord-010119-t1x9gknd 8630 4 covers cover VBZ cord-010119-t1x9gknd 8630 5 triggers trigger NNS cord-010119-t1x9gknd 8630 6 in in IN cord-010119-t1x9gknd 8630 7 the the DT cord-010119-t1x9gknd 8630 8 two two CD cord-010119-t1x9gknd 8630 9 month month NN cord-010119-t1x9gknd 8630 10 postimplementation postimplementation NN cord-010119-t1x9gknd 8630 11 of of IN cord-010119-t1x9gknd 8630 12 the the DT cord-010119-t1x9gknd 8630 13 BPA BPA NNP cord-010119-t1x9gknd 8630 14 . . . cord-010119-t1x9gknd 8631 1 The the DT cord-010119-t1x9gknd 8631 2 BPA BPA NNP cord-010119-t1x9gknd 8631 3 triggered trigger VBD cord-010119-t1x9gknd 8631 4 33 33 CD cord-010119-t1x9gknd 8631 5 times time NNS cord-010119-t1x9gknd 8631 6 in in IN cord-010119-t1x9gknd 8631 7 total total JJ cord-010119-t1x9gknd 8631 8 , , , cord-010119-t1x9gknd 8631 9 affecting affect VBG cord-010119-t1x9gknd 8631 10 15 15 CD cord-010119-t1x9gknd 8631 11 patients patient NNS cord-010119-t1x9gknd 8631 12 and and CC cord-010119-t1x9gknd 8631 13 21 21 CD cord-010119-t1x9gknd 8631 14 users user NNS cord-010119-t1x9gknd 8631 15 . . . cord-010119-t1x9gknd 8632 1 Stratified stratify VBN cord-010119-t1x9gknd 8632 2 by by IN cord-010119-t1x9gknd 8632 3 location location NN cord-010119-t1x9gknd 8632 4 , , , cord-010119-t1x9gknd 8632 5 the the DT cord-010119-t1x9gknd 8632 6 majority majority NN cord-010119-t1x9gknd 8632 7 of of IN cord-010119-t1x9gknd 8632 8 triggers trigger NNS cord-010119-t1x9gknd 8632 9 occurred occur VBD cord-010119-t1x9gknd 8632 10 in in IN cord-010119-t1x9gknd 8632 11 the the DT cord-010119-t1x9gknd 8632 12 perioperative perioperative JJ cord-010119-t1x9gknd 8632 13 areas area NNS cord-010119-t1x9gknd 8632 14 ( ( -LRB- cord-010119-t1x9gknd 8632 15 18 18 CD cord-010119-t1x9gknd 8632 16 times time NNS cord-010119-t1x9gknd 8632 17 ) ) -RRB- cord-010119-t1x9gknd 8632 18 and and CC cord-010119-t1x9gknd 8632 19 the the DT cord-010119-t1x9gknd 8632 20 liver liver NN cord-010119-t1x9gknd 8632 21 ICU ICU NNP cord-010119-t1x9gknd 8632 22 ( ( -LRB- cord-010119-t1x9gknd 8632 23 6 6 CD cord-010119-t1x9gknd 8632 24 times time NNS cord-010119-t1x9gknd 8632 25 ) ) -RRB- cord-010119-t1x9gknd 8632 26 with with IN cord-010119-t1x9gknd 8632 27 a a DT cord-010119-t1x9gknd 8632 28 minority minority NN cord-010119-t1x9gknd 8632 29 occurring occur VBG cord-010119-t1x9gknd 8632 30 on on IN cord-010119-t1x9gknd 8632 31 the the DT cord-010119-t1x9gknd 8632 32 regular regular JJ cord-010119-t1x9gknd 8632 33 hospital hospital NN cord-010119-t1x9gknd 8632 34 floors floor NNS cord-010119-t1x9gknd 8632 35 and and CC cord-010119-t1x9gknd 8632 36 emergency emergency NN cord-010119-t1x9gknd 8632 37 department department NN cord-010119-t1x9gknd 8632 38 . . . cord-010119-t1x9gknd 8633 1 Nurses nurse NNS cord-010119-t1x9gknd 8633 2 , , , cord-010119-t1x9gknd 8633 3 attendings attending NNS cord-010119-t1x9gknd 8633 4 , , , cord-010119-t1x9gknd 8633 5 residents resident NNS cord-010119-t1x9gknd 8633 6 , , , cord-010119-t1x9gknd 8633 7 pharmacists pharmacist NNS cord-010119-t1x9gknd 8633 8 , , , cord-010119-t1x9gknd 8633 9 and and CC cord-010119-t1x9gknd 8633 10 nurse nurse NN cord-010119-t1x9gknd 8633 11 anesthesiologists anesthesiologist NNS cord-010119-t1x9gknd 8633 12 were be VBD cord-010119-t1x9gknd 8633 13 the the DT cord-010119-t1x9gknd 8633 14 users user NNS cord-010119-t1x9gknd 8633 15 affected affect VBN cord-010119-t1x9gknd 8633 16 . . . cord-010119-t1x9gknd 8634 1 Orders order NNS cord-010119-t1x9gknd 8634 2 that that WDT cord-010119-t1x9gknd 8634 3 triggered trigger VBD cord-010119-t1x9gknd 8634 4 the the DT cord-010119-t1x9gknd 8634 5 BPA BPA NNP cord-010119-t1x9gknd 8634 6 included include VBD cord-010119-t1x9gknd 8634 7 type type NN cord-010119-t1x9gknd 8634 8 & & CC cord-010119-t1x9gknd 8634 9 screens screen NNS cord-010119-t1x9gknd 8634 10 , , , cord-010119-t1x9gknd 8634 11 Human Human NNP cord-010119-t1x9gknd 8634 12 albumin albumin NN cord-010119-t1x9gknd 8634 13 25 25 CD cord-010119-t1x9gknd 8634 14 % % NN cord-010119-t1x9gknd 8634 15 IV IV NNP cord-010119-t1x9gknd 8634 16 solution solution NN cord-010119-t1x9gknd 8634 17 , , , cord-010119-t1x9gknd 8634 18 Human human JJ cord-010119-t1x9gknd 8634 19 albumin albumin NN cord-010119-t1x9gknd 8634 20 5 5 CD cord-010119-t1x9gknd 8634 21 % % NN cord-010119-t1x9gknd 8634 22 IV IV NNP cord-010119-t1x9gknd 8634 23 solution solution NN cord-010119-t1x9gknd 8634 24 , , , cord-010119-t1x9gknd 8634 25 Immune Immune NNP cord-010119-t1x9gknd 8634 26 Globulin Globulin NNP cord-010119-t1x9gknd 8634 27 ( ( -LRB- cord-010119-t1x9gknd 8634 28 Human Human NNP cord-010119-t1x9gknd 8634 29 ) ) -RRB- cord-010119-t1x9gknd 8634 30 solution solution NN cord-010119-t1x9gknd 8634 31 . . . cord-010119-t1x9gknd 8635 1 Conclusion conclusion NN cord-010119-t1x9gknd 8635 2 : : : cord-010119-t1x9gknd 8636 1 Despite despite IN cord-010119-t1x9gknd 8636 2 the the DT cord-010119-t1x9gknd 8636 3 limited limited JJ cord-010119-t1x9gknd 8636 4 and and CC cord-010119-t1x9gknd 8636 5 very very RB cord-010119-t1x9gknd 8636 6 preliminary preliminary JJ cord-010119-t1x9gknd 8636 7 data datum NNS cord-010119-t1x9gknd 8636 8 , , , cord-010119-t1x9gknd 8636 9 the the DT cord-010119-t1x9gknd 8636 10 user user NN cord-010119-t1x9gknd 8636 11 action action NN cord-010119-t1x9gknd 8636 12 findings finding NNS cord-010119-t1x9gknd 8636 13 seem seem VBP cord-010119-t1x9gknd 8636 14 to to TO cord-010119-t1x9gknd 8636 15 indicate indicate VB cord-010119-t1x9gknd 8636 16 that that IN cord-010119-t1x9gknd 8636 17 the the DT cord-010119-t1x9gknd 8636 18 BPA BPA NNP cord-010119-t1x9gknd 8636 19 is be VBZ cord-010119-t1x9gknd 8636 20 effective effective JJ cord-010119-t1x9gknd 8636 21 in in IN cord-010119-t1x9gknd 8636 22 halting halt VBG cord-010119-t1x9gknd 8636 23 up up RP cord-010119-t1x9gknd 8636 24 to to IN cord-010119-t1x9gknd 8636 25 half half NN cord-010119-t1x9gknd 8636 26 of of IN cord-010119-t1x9gknd 8636 27 the the DT cord-010119-t1x9gknd 8636 28 contraindicated contraindicated JJ cord-010119-t1x9gknd 8636 29 orders order NNS cord-010119-t1x9gknd 8636 30 for for IN cord-010119-t1x9gknd 8636 31 blood blood NN cord-010119-t1x9gknd 8636 32 - - HYPH cord-010119-t1x9gknd 8636 33 derived derive VBN cord-010119-t1x9gknd 8636 34 products product NNS cord-010119-t1x9gknd 8636 35 and and CC cord-010119-t1x9gknd 8636 36 type type NN cord-010119-t1x9gknd 8636 37 & & CC cord-010119-t1x9gknd 8636 38 screens screen NNS cord-010119-t1x9gknd 8636 39 orders order NNS cord-010119-t1x9gknd 8636 40 . . . cord-010119-t1x9gknd 8637 1 Given give VBN cord-010119-t1x9gknd 8637 2 the the DT cord-010119-t1x9gknd 8637 3 limited limited JJ cord-010119-t1x9gknd 8637 4 types type NNS cord-010119-t1x9gknd 8637 5 of of IN cord-010119-t1x9gknd 8637 6 orders order NNS cord-010119-t1x9gknd 8637 7 that that IN cord-010119-t1x9gknd 8637 8 the the DT cord-010119-t1x9gknd 8637 9 BPA BPA NNP cord-010119-t1x9gknd 8637 10 is be VBZ cord-010119-t1x9gknd 8637 11 triggering trigger VBG cord-010119-t1x9gknd 8637 12 on on IN cord-010119-t1x9gknd 8637 13 , , , cord-010119-t1x9gknd 8637 14 the the DT cord-010119-t1x9gknd 8637 15 pattern pattern NN cord-010119-t1x9gknd 8637 16 suggests suggest VBZ cord-010119-t1x9gknd 8637 17 that that IN cord-010119-t1x9gknd 8637 18 the the DT cord-010119-t1x9gknd 8637 19 BPA BPA NNP cord-010119-t1x9gknd 8637 20 is be VBZ cord-010119-t1x9gknd 8637 21 potentially potentially RB cord-010119-t1x9gknd 8637 22 alerting alert VBG cord-010119-t1x9gknd 8637 23 some some DT cord-010119-t1x9gknd 8637 24 previously previously RB cord-010119-t1x9gknd 8637 25 unaware unaware JJ cord-010119-t1x9gknd 8637 26 providers provider NNS cord-010119-t1x9gknd 8637 27 of of IN cord-010119-t1x9gknd 8637 28 the the DT cord-010119-t1x9gknd 8637 29 patient patient NN cord-010119-t1x9gknd 8637 30 's 's POS cord-010119-t1x9gknd 8637 31 religious religious JJ cord-010119-t1x9gknd 8637 32 status status NN cord-010119-t1x9gknd 8637 33 and/or and/or CC cord-010119-t1x9gknd 8637 34 the the DT cord-010119-t1x9gknd 8637 35 fact fact NN cord-010119-t1x9gknd 8637 36 that that IN cord-010119-t1x9gknd 8637 37 certain certain JJ cord-010119-t1x9gknd 8637 38 pharmacy pharmacy NN cord-010119-t1x9gknd 8637 39 items item NNS cord-010119-t1x9gknd 8637 40 are be VBP cord-010119-t1x9gknd 8637 41 blood blood NN cord-010119-t1x9gknd 8637 42 - - HYPH cord-010119-t1x9gknd 8637 43 derived derive VBN cord-010119-t1x9gknd 8637 44 , , , cord-010119-t1x9gknd 8637 45 and and CC cord-010119-t1x9gknd 8637 46 therefore therefore RB cord-010119-t1x9gknd 8637 47 unacceptable unacceptable JJ cord-010119-t1x9gknd 8637 48 to to IN cord-010119-t1x9gknd 8637 49 many many JJ cord-010119-t1x9gknd 8637 50 JW JW NNP cord-010119-t1x9gknd 8637 51 patients patient NNS cord-010119-t1x9gknd 8637 52 . . . cord-010119-t1x9gknd 8638 1 Despite despite IN cord-010119-t1x9gknd 8638 2 these these DT cord-010119-t1x9gknd 8638 3 positive positive JJ cord-010119-t1x9gknd 8638 4 initial initial JJ cord-010119-t1x9gknd 8638 5 findings finding NNS cord-010119-t1x9gknd 8638 6 , , , cord-010119-t1x9gknd 8638 7 this this DT cord-010119-t1x9gknd 8638 8 is be VBZ cord-010119-t1x9gknd 8638 9 an an DT cord-010119-t1x9gknd 8638 10 ongoing ongoing JJ cord-010119-t1x9gknd 8638 11 study study NN cord-010119-t1x9gknd 8638 12 to to TO cord-010119-t1x9gknd 8638 13 track track VB cord-010119-t1x9gknd 8638 14 the the DT cord-010119-t1x9gknd 8638 15 efficacy efficacy NN cord-010119-t1x9gknd 8638 16 of of IN cord-010119-t1x9gknd 8638 17 the the DT cord-010119-t1x9gknd 8638 18 BPA BPA NNP cord-010119-t1x9gknd 8638 19 and and CC cord-010119-t1x9gknd 8638 20 more more JJR cord-010119-t1x9gknd 8638 21 data datum NNS cord-010119-t1x9gknd 8638 22 needs need VBZ cord-010119-t1x9gknd 8638 23 to to TO cord-010119-t1x9gknd 8638 24 be be VB cord-010119-t1x9gknd 8638 25 collected collect VBN cord-010119-t1x9gknd 8638 26 for for IN cord-010119-t1x9gknd 8638 27 better well JJR cord-010119-t1x9gknd 8638 28 metrics metric NNS cord-010119-t1x9gknd 8638 29 of of IN cord-010119-t1x9gknd 8638 30 the the DT cord-010119-t1x9gknd 8638 31 institutional institutional JJ cord-010119-t1x9gknd 8638 32 sensitivity sensitivity NN cord-010119-t1x9gknd 8638 33 to to IN cord-010119-t1x9gknd 8638 34 patient patient JJ cord-010119-t1x9gknd 8638 35 blood blood NN cord-010119-t1x9gknd 8638 36 refusal refusal NN cord-010119-t1x9gknd 8638 37 . . . cord-010119-t1x9gknd 8639 1 Intervention intervention NN cord-010119-t1x9gknd 8639 2 to to IN cord-010119-t1x9gknd 8639 3 Address Address NNP cord-010119-t1x9gknd 8639 4 Inappropriate Inappropriate NNP cord-010119-t1x9gknd 8639 5 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 8639 6 - - HYPH cord-010119-t1x9gknd 8639 7 AHF AHF NNP cord-010119-t1x9gknd 8639 8 Orders order NNS cord-010119-t1x9gknd 8639 9 at at IN cord-010119-t1x9gknd 8639 10 a a DT cord-010119-t1x9gknd 8639 11 Tertiary Tertiary NNP cord-010119-t1x9gknd 8639 12 Medical Medical NNP cord-010119-t1x9gknd 8639 13 Center Center NNP cord-010119-t1x9gknd 8639 14 Sirisha Sirisha NNP cord-010119-t1x9gknd 8639 15 Kundrapu Kundrapu NNP cord-010119-t1x9gknd 8639 16 * * NFP cord-010119-t1x9gknd 8639 17 1,2 1,2 CD cord-010119-t1x9gknd 8639 18 , , , cord-010119-t1x9gknd 8639 19 Mahmut Mahmut NNP cord-010119-t1x9gknd 8639 20 Akgul Akgul NNP cord-010119-t1x9gknd 8639 21 1,2 1,2 CD cord-010119-t1x9gknd 8639 22 , , , cord-010119-t1x9gknd 8639 23 Hollie Hollie NNP cord-010119-t1x9gknd 8639 24 M M NNP cord-010119-t1x9gknd 8639 25 Reeves Reeves NNP cord-010119-t1x9gknd 8639 26 1,2 1,2 CD cord-010119-t1x9gknd 8639 27 , , , cord-010119-t1x9gknd 8639 28 Robert Robert NNP cord-010119-t1x9gknd 8639 29 W W NNP cord-010119-t1x9gknd 8639 30 Maitta Maitta NNP cord-010119-t1x9gknd 8639 31 1,2 1,2 CD cord-010119-t1x9gknd 8639 32 , , , cord-010119-t1x9gknd 8639 33 Marcie Marcie NNP cord-010119-t1x9gknd 8639 34 Pokorny Pokorny NNP cord-010119-t1x9gknd 8639 35 2 2 CD cord-010119-t1x9gknd 8639 36 , , , cord-010119-t1x9gknd 8639 37 Anne Anne NNP cord-010119-t1x9gknd 8639 38 Capetillo Capetillo NNP cord-010119-t1x9gknd 8639 39 2 2 CD cord-010119-t1x9gknd 8639 40 and and CC cord-010119-t1x9gknd 8639 41 Katharine Katharine NNP cord-010119-t1x9gknd 8639 42 A A NNP cord-010119-t1x9gknd 8639 43 Downes Downes NNP cord-010119-t1x9gknd 8639 44 1,2 1,2 CD cord-010119-t1x9gknd 8639 45 . . . cord-010119-t1x9gknd 8640 1 Background Background NNP cord-010119-t1x9gknd 8640 2 / / SYM cord-010119-t1x9gknd 8640 3 Case Case NNP cord-010119-t1x9gknd 8640 4 Studies Studies NNPS cord-010119-t1x9gknd 8640 5 : : : cord-010119-t1x9gknd 8640 6 Although although IN cord-010119-t1x9gknd 8640 7 introduced introduce VBN cord-010119-t1x9gknd 8640 8 for for IN cord-010119-t1x9gknd 8640 9 the the DT cord-010119-t1x9gknd 8640 10 management management NN cord-010119-t1x9gknd 8640 11 of of IN cord-010119-t1x9gknd 8640 12 hemophilia hemophilia NNP cord-010119-t1x9gknd 8640 13 A A NNP cord-010119-t1x9gknd 8640 14 , , , cord-010119-t1x9gknd 8640 15 now now RB cord-010119-t1x9gknd 8640 16 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8640 17 is be VBZ cord-010119-t1x9gknd 8640 18 primarily primarily RB cord-010119-t1x9gknd 8640 19 indicated indicate VBN cord-010119-t1x9gknd 8640 20 for for IN cord-010119-t1x9gknd 8640 21 low low JJ cord-010119-t1x9gknd 8640 22 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8640 23 levels level NNS cord-010119-t1x9gknd 8640 24 . . . cord-010119-t1x9gknd 8641 1 At at IN cord-010119-t1x9gknd 8641 2 our -PRON- PRP$ cord-010119-t1x9gknd 8641 3 institution institution NN cord-010119-t1x9gknd 8641 4 the the DT cord-010119-t1x9gknd 8641 5 transfusion transfusion NN cord-010119-t1x9gknd 8641 6 medicine medicine NN cord-010119-t1x9gknd 8641 7 service service NN cord-010119-t1x9gknd 8641 8 ( ( -LRB- cord-010119-t1x9gknd 8641 9 TMS TMS NNP cord-010119-t1x9gknd 8641 10 ) ) -RRB- cord-010119-t1x9gknd 8641 11 reviews review NNS cord-010119-t1x9gknd 8641 12 and and CC cord-010119-t1x9gknd 8641 13 makes make VBZ cord-010119-t1x9gknd 8641 14 recommendations recommendation NNS cord-010119-t1x9gknd 8641 15 to to IN cord-010119-t1x9gknd 8641 16 clinicians clinician NNS cord-010119-t1x9gknd 8641 17 for for IN cord-010119-t1x9gknd 8641 18 all all DT cord-010119-t1x9gknd 8641 19 inappropriate inappropriate JJ cord-010119-t1x9gknd 8641 20 cryoprecipitate cryoprecipitate JJ cord-010119-t1x9gknd 8641 21 orders order NNS cord-010119-t1x9gknd 8641 22 . . . cord-010119-t1x9gknd 8642 1 We -PRON- PRP cord-010119-t1x9gknd 8642 2 aimed aim VBD cord-010119-t1x9gknd 8642 3 at at IN cord-010119-t1x9gknd 8642 4 analyzing analyze VBG cord-010119-t1x9gknd 8642 5 the the DT cord-010119-t1x9gknd 8642 6 effectiveness effectiveness NN cord-010119-t1x9gknd 8642 7 of of IN cord-010119-t1x9gknd 8642 8 this this DT cord-010119-t1x9gknd 8642 9 intervention intervention NN cord-010119-t1x9gknd 8642 10 in in IN cord-010119-t1x9gknd 8642 11 reaching reach VBG cord-010119-t1x9gknd 8642 12 target target NN cord-010119-t1x9gknd 8642 13 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8642 14 levels level NNS cord-010119-t1x9gknd 8642 15 in in IN cord-010119-t1x9gknd 8642 16 under under RB cord-010119-t1x9gknd 8642 17 - - HYPH cord-010119-t1x9gknd 8642 18 estimated estimate VBN cord-010119-t1x9gknd 8642 19 and and CC cord-010119-t1x9gknd 8642 20 over over RB cord-010119-t1x9gknd 8642 21 - - HYPH cord-010119-t1x9gknd 8642 22 estimated estimate VBN cord-010119-t1x9gknd 8642 23 orders order NNS cord-010119-t1x9gknd 8642 24 . . . cord-010119-t1x9gknd 8643 1 Study Study NNP cord-010119-t1x9gknd 8643 2 Design Design NNP cord-010119-t1x9gknd 8643 3 / / SYM cord-010119-t1x9gknd 8643 4 Method method NN cord-010119-t1x9gknd 8643 5 : : : cord-010119-t1x9gknd 8643 6 We -PRON- PRP cord-010119-t1x9gknd 8643 7 conducted conduct VBD cord-010119-t1x9gknd 8643 8 a a DT cord-010119-t1x9gknd 8643 9 7-month 7-month NNP cord-010119-t1x9gknd 8643 10 retrospective retrospective JJ cord-010119-t1x9gknd 8643 11 study study NN cord-010119-t1x9gknd 8643 12 ( ( -LRB- cord-010119-t1x9gknd 8643 13 January January NNP cord-010119-t1x9gknd 8643 14 - - HYPH cord-010119-t1x9gknd 8643 15 July July NNP cord-010119-t1x9gknd 8643 16 2016 2016 CD cord-010119-t1x9gknd 8643 17 ) ) -RRB- cord-010119-t1x9gknd 8643 18 of of IN cord-010119-t1x9gknd 8643 19 adult adult NN cord-010119-t1x9gknd 8643 20 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8643 21 order order NN cord-010119-t1x9gknd 8643 22 quality quality NNP cord-010119-t1x9gknd 8643 23 assurance assurance NN cord-010119-t1x9gknd 8643 24 forms form NNS cord-010119-t1x9gknd 8643 25 . . . cord-010119-t1x9gknd 8644 1 The the DT cord-010119-t1x9gknd 8644 2 reference reference NN cord-010119-t1x9gknd 8644 3 range range NN cord-010119-t1x9gknd 8644 4 for for IN cord-010119-t1x9gknd 8644 5 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8644 6 was be VBD cord-010119-t1x9gknd 8645 1 200 200 CD cord-010119-t1x9gknd 8645 2 - - SYM cord-010119-t1x9gknd 8645 3 400 400 CD cord-010119-t1x9gknd 8645 4 mg mg NNP cord-010119-t1x9gknd 8645 5 / / SYM cord-010119-t1x9gknd 8645 6 dl dl NN cord-010119-t1x9gknd 8645 7 with with IN cord-010119-t1x9gknd 8645 8 critical critical JJ cord-010119-t1x9gknd 8645 9 value value NN cord-010119-t1x9gknd 8645 10 of of IN cord-010119-t1x9gknd 8645 11 50mg 50mg NN cord-010119-t1x9gknd 8645 12 / / SYM cord-010119-t1x9gknd 8645 13 dl dl NN cord-010119-t1x9gknd 8645 14 . . . cord-010119-t1x9gknd 8646 1 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 8646 2 orders order NNS cord-010119-t1x9gknd 8646 3 for for IN cord-010119-t1x9gknd 8646 4 massive massive JJ cord-010119-t1x9gknd 8646 5 transfusion transfusion NN cord-010119-t1x9gknd 8646 6 protocol protocol NN cord-010119-t1x9gknd 8646 7 , , , cord-010119-t1x9gknd 8646 8 from from IN cord-010119-t1x9gknd 8646 9 operating operate VBG cord-010119-t1x9gknd 8646 10 rooms room NNS cord-010119-t1x9gknd 8646 11 and and CC cord-010119-t1x9gknd 8646 12 for for IN cord-010119-t1x9gknd 8646 13 extracorporeal extracorporeal JJ cord-010119-t1x9gknd 8646 14 membrane membrane NN cord-010119-t1x9gknd 8646 15 oxygenation oxygenation NN cord-010119-t1x9gknd 8646 16 were be VBD cord-010119-t1x9gknd 8646 17 not not RB cord-010119-t1x9gknd 8646 18 reviewed review VBN cord-010119-t1x9gknd 8646 19 by by IN cord-010119-t1x9gknd 8646 20 the the DT cord-010119-t1x9gknd 8646 21 TMS TMS NNP cord-010119-t1x9gknd 8646 22 . . . cord-010119-t1x9gknd 8647 1 During during IN cord-010119-t1x9gknd 8647 2 the the DT cord-010119-t1x9gknd 8647 3 study study NN cord-010119-t1x9gknd 8647 4 period period NN cord-010119-t1x9gknd 8647 5 , , , cord-010119-t1x9gknd 8647 6 TMS TMS NNP cord-010119-t1x9gknd 8647 7 evaluated evaluate VBD cord-010119-t1x9gknd 8647 8 orders order NNS cord-010119-t1x9gknd 8647 9 for for IN cord-010119-t1x9gknd 8647 10 appropriateness appropriateness NN cord-010119-t1x9gknd 8647 11 of of IN cord-010119-t1x9gknd 8647 12 dosing dosing NN cord-010119-t1x9gknd 8647 13 and and CC cord-010119-t1x9gknd 8647 14 agreement agreement NN cord-010119-t1x9gknd 8647 15 with with IN cord-010119-t1x9gknd 8647 16 estimated estimate VBN cord-010119-t1x9gknd 8647 17 required require VBN cord-010119-t1x9gknd 8647 18 doses dose NNS cord-010119-t1x9gknd 8647 19 . . . cord-010119-t1x9gknd 8648 1 Post post JJ cord-010119-t1x9gknd 8648 2 - - JJ cord-010119-t1x9gknd 8648 3 transfusion transfusion NN cord-010119-t1x9gknd 8648 4 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8648 5 levels level NNS cord-010119-t1x9gknd 8648 6 due due JJ cord-010119-t1x9gknd 8648 7 to to IN cord-010119-t1x9gknd 8648 8 intervention intervention NN cord-010119-t1x9gknd 8648 9 were be VBD cord-010119-t1x9gknd 8648 10 compared compare VBN cord-010119-t1x9gknd 8648 11 with with IN cord-010119-t1x9gknd 8648 12 hypothesized hypothesize VBN cord-010119-t1x9gknd 8648 13 no no DT cord-010119-t1x9gknd 8648 14 intervention intervention NN cord-010119-t1x9gknd 8648 15 levels level NNS cord-010119-t1x9gknd 8648 16 . . . cord-010119-t1x9gknd 8649 1 Statistical statistical JJ cord-010119-t1x9gknd 8649 2 analysis analysis NN cord-010119-t1x9gknd 8649 3 was be VBD cord-010119-t1x9gknd 8649 4 performed perform VBN cord-010119-t1x9gknd 8649 5 using use VBG cord-010119-t1x9gknd 8649 6 chi chi NNP cord-010119-t1x9gknd 8649 7 - - HYPH cord-010119-t1x9gknd 8649 8 square square NNP cord-010119-t1x9gknd 8649 9 and and CC cord-010119-t1x9gknd 8649 10 t t NN cord-010119-t1x9gknd 8649 11 - - HYPH cord-010119-t1x9gknd 8649 12 tests test NNS cord-010119-t1x9gknd 8649 13 . . . cord-010119-t1x9gknd 8650 1 Results/ Results/ . cord-010119-t1x9gknd 8651 1 Finding find VBG cord-010119-t1x9gknd 8652 1 : : : cord-010119-t1x9gknd 8652 2 There there EX cord-010119-t1x9gknd 8652 3 were be VBD cord-010119-t1x9gknd 8652 4 301 301 CD cord-010119-t1x9gknd 8652 5 adult adult NN cord-010119-t1x9gknd 8652 6 ( ( -LRB- cord-010119-t1x9gknd 8652 7 > > NFP cord-010119-t1x9gknd 8652 8 18 18 CD cord-010119-t1x9gknd 8652 9 years year NNS cord-010119-t1x9gknd 8652 10 ) ) -RRB- cord-010119-t1x9gknd 8652 11 orders order NNS cord-010119-t1x9gknd 8652 12 reviewed review VBN cord-010119-t1x9gknd 8652 13 by by IN cord-010119-t1x9gknd 8652 14 TMS TMS NNP cord-010119-t1x9gknd 8652 15 out out IN cord-010119-t1x9gknd 8652 16 of of IN cord-010119-t1x9gknd 8652 17 which which WDT cord-010119-t1x9gknd 8652 18 299 299 CD cord-010119-t1x9gknd 8652 19 were be VBD cord-010119-t1x9gknd 8652 20 approved approve VBN cord-010119-t1x9gknd 8652 21 . . . cord-010119-t1x9gknd 8653 1 Of of IN cord-010119-t1x9gknd 8653 2 the the DT cord-010119-t1x9gknd 8653 3 299 299 CD cord-010119-t1x9gknd 8653 4 approved approve VBN cord-010119-t1x9gknd 8653 5 orders order NNS cord-010119-t1x9gknd 8653 6 , , , cord-010119-t1x9gknd 8653 7 136 136 CD cord-010119-t1x9gknd 8653 8 ( ( -LRB- cord-010119-t1x9gknd 8653 9 45.5 45.5 CD cord-010119-t1x9gknd 8653 10 % % NN cord-010119-t1x9gknd 8653 11 ) ) -RRB- cord-010119-t1x9gknd 8653 12 were be VBD cord-010119-t1x9gknd 8653 13 in in IN cord-010119-t1x9gknd 8653 14 agreement agreement NN cord-010119-t1x9gknd 8653 15 with with IN cord-010119-t1x9gknd 8653 16 TMS TMS NNP cord-010119-t1x9gknd 8653 17 's 's POS cord-010119-t1x9gknd 8653 18 estimated estimate VBN cord-010119-t1x9gknd 8653 19 dose dose NN cord-010119-t1x9gknd 8653 20 . . . cord-010119-t1x9gknd 8654 1 Of of IN cord-010119-t1x9gknd 8654 2 163 163 CD cord-010119-t1x9gknd 8654 3 ( ( -LRB- cord-010119-t1x9gknd 8654 4 54.5 54.5 CD cord-010119-t1x9gknd 8654 5 % % NN cord-010119-t1x9gknd 8654 6 ) ) -RRB- cord-010119-t1x9gknd 8654 7 orders order NNS cord-010119-t1x9gknd 8654 8 that that WDT cord-010119-t1x9gknd 8654 9 were be VBD cord-010119-t1x9gknd 8654 10 not not RB cord-010119-t1x9gknd 8654 11 in in IN cord-010119-t1x9gknd 8654 12 agreement agreement NN cord-010119-t1x9gknd 8654 13 with with IN cord-010119-t1x9gknd 8654 14 the the DT cord-010119-t1x9gknd 8654 15 TMS TMS NNP cord-010119-t1x9gknd 8654 16 's 's POS cord-010119-t1x9gknd 8654 17 estimate estimate NN cord-010119-t1x9gknd 8654 18 , , , cord-010119-t1x9gknd 8654 19 142 142 CD cord-010119-t1x9gknd 8654 20 ( ( -LRB- cord-010119-t1x9gknd 8654 21 47 47 CD cord-010119-t1x9gknd 8654 22 % % NN cord-010119-t1x9gknd 8654 23 ) ) -RRB- cord-010119-t1x9gknd 8654 24 were be VBD cord-010119-t1x9gknd 8654 25 underestimated underestimate VBN cord-010119-t1x9gknd 8654 26 and and CC cord-010119-t1x9gknd 8654 27 21 21 CD cord-010119-t1x9gknd 8654 28 ( ( -LRB- cord-010119-t1x9gknd 8654 29 7 7 CD cord-010119-t1x9gknd 8654 30 % % NN cord-010119-t1x9gknd 8654 31 ) ) -RRB- cord-010119-t1x9gknd 8654 32 were be VBD cord-010119-t1x9gknd 8654 33 overestimated overestimate VBN cord-010119-t1x9gknd 8654 34 . . . cord-010119-t1x9gknd 8655 1 Seventeen seventeen CD cord-010119-t1x9gknd 8655 2 of of IN cord-010119-t1x9gknd 8655 3 299 299 CD cord-010119-t1x9gknd 8655 4 orders order NNS cord-010119-t1x9gknd 8655 5 had have VBD cord-010119-t1x9gknd 8655 6 no no DT cord-010119-t1x9gknd 8655 7 post post JJ cord-010119-t1x9gknd 8655 8 - - JJ cord-010119-t1x9gknd 8655 9 transfusion transfusion JJ cord-010119-t1x9gknd 8655 10 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8655 11 levels level NNS cord-010119-t1x9gknd 8655 12 . . . cord-010119-t1x9gknd 8656 1 Without without IN cord-010119-t1x9gknd 8656 2 intervention intervention NN cord-010119-t1x9gknd 8656 3 , , , cord-010119-t1x9gknd 8656 4 there there EX cord-010119-t1x9gknd 8656 5 would would MD cord-010119-t1x9gknd 8656 6 have have VB cord-010119-t1x9gknd 8656 7 been be VBN cord-010119-t1x9gknd 8656 8 a a DT cord-010119-t1x9gknd 8656 9 median median JJ cord-010119-t1x9gknd 8656 10 deficit deficit NN cord-010119-t1x9gknd 8656 11 of of IN cord-010119-t1x9gknd 8656 12 23.6 23.6 CD cord-010119-t1x9gknd 8656 13 mg mg NNP cord-010119-t1x9gknd 8656 14 / / SYM cord-010119-t1x9gknd 8656 15 dl dl NNP cord-010119-t1x9gknd 8656 16 ( ( -LRB- cord-010119-t1x9gknd 8656 17 range range VBP cord-010119-t1x9gknd 8656 18 0.3 0.3 CD cord-010119-t1x9gknd 8656 19 to to IN cord-010119-t1x9gknd 8656 20 124 124 CD cord-010119-t1x9gknd 8656 21 mg mg NNP cord-010119-t1x9gknd 8656 22 / / SYM cord-010119-t1x9gknd 8656 23 dl dl NNP cord-010119-t1x9gknd 8656 24 ) ) -RRB- cord-010119-t1x9gknd 8656 25 and and CC cord-010119-t1x9gknd 8656 26 a a DT cord-010119-t1x9gknd 8656 27 median median JJ cord-010119-t1x9gknd 8656 28 excess excess NN cord-010119-t1x9gknd 8656 29 of of IN cord-010119-t1x9gknd 8656 30 13.3 13.3 CD cord-010119-t1x9gknd 8656 31 mg mg NNP cord-010119-t1x9gknd 8656 32 / / SYM cord-010119-t1x9gknd 8656 33 dl dl NNP cord-010119-t1x9gknd 8656 34 ( ( -LRB- cord-010119-t1x9gknd 8656 35 range range VBP cord-010119-t1x9gknd 8656 36 0.6 0.6 CD cord-010119-t1x9gknd 8656 37 to to IN cord-010119-t1x9gknd 8656 38 155 155 CD cord-010119-t1x9gknd 8656 39 mg mg NNP cord-010119-t1x9gknd 8656 40 / / SYM cord-010119-t1x9gknd 8656 41 dl dl NNP cord-010119-t1x9gknd 8656 42 ) ) -RRB- cord-010119-t1x9gknd 8656 43 of of IN cord-010119-t1x9gknd 8656 44 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8656 45 from from IN cord-010119-t1x9gknd 8656 46 the the DT cord-010119-t1x9gknd 8656 47 target target NN cord-010119-t1x9gknd 8656 48 . . . cord-010119-t1x9gknd 8657 1 Median median JJ cord-010119-t1x9gknd 8657 2 difference difference NN cord-010119-t1x9gknd 8657 3 between between IN cord-010119-t1x9gknd 8657 4 target target NN cord-010119-t1x9gknd 8657 5 and and CC cord-010119-t1x9gknd 8657 6 actual actual JJ cord-010119-t1x9gknd 8657 7 post post JJ cord-010119-t1x9gknd 8657 8 - - JJ cord-010119-t1x9gknd 8657 9 transfusion transfusion JJ cord-010119-t1x9gknd 8657 10 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8657 11 level level NN cord-010119-t1x9gknd 8657 12 was be VBD cord-010119-t1x9gknd 8657 13 12 12 CD cord-010119-t1x9gknd 8657 14 mg mg NNP cord-010119-t1x9gknd 8657 15 / / SYM cord-010119-t1x9gknd 8657 16 dl dl NN cord-010119-t1x9gknd 8657 17 above above IN cord-010119-t1x9gknd 8657 18 target target NN cord-010119-t1x9gknd 8657 19 , , , cord-010119-t1x9gknd 8657 20 which which WDT cord-010119-t1x9gknd 8657 21 is be VBZ cord-010119-t1x9gknd 8657 22 significantly significantly RB cord-010119-t1x9gknd 8657 23 higher high JJR cord-010119-t1x9gknd 8657 24 with with IN cord-010119-t1x9gknd 8657 25 intervention intervention NN cord-010119-t1x9gknd 8657 26 than than IN cord-010119-t1x9gknd 8657 27 without without IN cord-010119-t1x9gknd 8657 28 ( ( -LRB- cord-010119-t1x9gknd 8657 29 which which WDT cord-010119-t1x9gknd 8657 30 could could MD cord-010119-t1x9gknd 8657 31 have have VB cord-010119-t1x9gknd 8657 32 been be VBN cord-010119-t1x9gknd 8657 33 12 12 CD cord-010119-t1x9gknd 8657 34 mg mg NNP cord-010119-t1x9gknd 8657 35 / / SYM cord-010119-t1x9gknd 8657 36 dl dl NN cord-010119-t1x9gknd 8657 37 below below IN cord-010119-t1x9gknd 8657 38 the the DT cord-010119-t1x9gknd 8657 39 target target NN cord-010119-t1x9gknd 8657 40 ; ; : cord-010119-t1x9gknd 8657 41 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 8657 42 ) ) -RRB- cord-010119-t1x9gknd 8657 43 . . . cord-010119-t1x9gknd 8658 1 Median median JJ cord-010119-t1x9gknd 8658 2 differences difference NNS cord-010119-t1x9gknd 8658 3 between between IN cord-010119-t1x9gknd 8658 4 target target NN cord-010119-t1x9gknd 8658 5 and and CC cord-010119-t1x9gknd 8658 6 post post JJ cord-010119-t1x9gknd 8658 7 - - JJ cord-010119-t1x9gknd 8658 8 transfusion transfusion JJ cord-010119-t1x9gknd 8658 9 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8658 10 levels level NNS cord-010119-t1x9gknd 8658 11 for for IN cord-010119-t1x9gknd 8658 12 the the DT cord-010119-t1x9gknd 8658 13 group group NN cord-010119-t1x9gknd 8658 14 with with IN cord-010119-t1x9gknd 8658 15 agreement agreement NN cord-010119-t1x9gknd 8658 16 between between IN cord-010119-t1x9gknd 8658 17 approved approve VBN cord-010119-t1x9gknd 8658 18 and and CC cord-010119-t1x9gknd 8658 19 requested request VBN cord-010119-t1x9gknd 8658 20 units unit NNS cord-010119-t1x9gknd 8658 21 was be VBD cord-010119-t1x9gknd 8658 22 not not RB cord-010119-t1x9gknd 8658 23 significantly significantly RB cord-010119-t1x9gknd 8658 24 different different JJ cord-010119-t1x9gknd 8658 25 from from IN cord-010119-t1x9gknd 8658 26 possible possible JJ cord-010119-t1x9gknd 8658 27 differences difference NNS cord-010119-t1x9gknd 8658 28 without without IN cord-010119-t1x9gknd 8658 29 intervention intervention NN cord-010119-t1x9gknd 8658 30 ( ( -LRB- cord-010119-t1x9gknd 8658 31 11 11 CD cord-010119-t1x9gknd 8658 32 vs. vs. IN cord-010119-t1x9gknd 8658 33 2.7 2.7 CD cord-010119-t1x9gknd 8658 34 mg mg NNP cord-010119-t1x9gknd 8658 35 / / SYM cord-010119-t1x9gknd 8658 36 dl dl NNP cord-010119-t1x9gknd 8658 37 , , , cord-010119-t1x9gknd 8658 38 p50.07 p50.07 NNP cord-010119-t1x9gknd 8658 39 ) ) -RRB- cord-010119-t1x9gknd 8658 40 . . . cord-010119-t1x9gknd 8659 1 Median median JJ cord-010119-t1x9gknd 8659 2 differences difference NNS cord-010119-t1x9gknd 8659 3 between between IN cord-010119-t1x9gknd 8659 4 target target NN cord-010119-t1x9gknd 8659 5 and and CC cord-010119-t1x9gknd 8659 6 post post JJ cord-010119-t1x9gknd 8659 7 - - JJ cord-010119-t1x9gknd 8659 8 transfusion transfusion JJ cord-010119-t1x9gknd 8659 9 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8659 10 levels level NNS cord-010119-t1x9gknd 8659 11 for for IN cord-010119-t1x9gknd 8659 12 the the DT cord-010119-t1x9gknd 8659 13 group group NN cord-010119-t1x9gknd 8659 14 with with IN cord-010119-t1x9gknd 8659 15 non non JJ cord-010119-t1x9gknd 8659 16 - - JJ cord-010119-t1x9gknd 8659 17 agreement agreement NN cord-010119-t1x9gknd 8659 18 between between IN cord-010119-t1x9gknd 8659 19 approved approve VBN cord-010119-t1x9gknd 8659 20 and and CC cord-010119-t1x9gknd 8659 21 requested request VBN cord-010119-t1x9gknd 8659 22 units unit NNS cord-010119-t1x9gknd 8659 23 was be VBD cord-010119-t1x9gknd 8659 24 significantly significantly RB cord-010119-t1x9gknd 8659 25 different different JJ cord-010119-t1x9gknd 8659 26 from from IN cord-010119-t1x9gknd 8659 27 possible possible JJ cord-010119-t1x9gknd 8659 28 difference difference NN cord-010119-t1x9gknd 8659 29 without without IN cord-010119-t1x9gknd 8659 30 intervention intervention NN cord-010119-t1x9gknd 8659 31 ( ( -LRB- cord-010119-t1x9gknd 8659 32 15 15 CD cord-010119-t1x9gknd 8659 33 vs. vs. IN cord-010119-t1x9gknd 8659 34 -23.5 -23.5 NNP cord-010119-t1x9gknd 8659 35 mg mg NNP cord-010119-t1x9gknd 8659 36 / / SYM cord-010119-t1x9gknd 8659 37 dl dl NNP cord-010119-t1x9gknd 8659 38 , , , cord-010119-t1x9gknd 8659 39 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 8659 40 ) ) -RRB- cord-010119-t1x9gknd 8659 41 . . . cord-010119-t1x9gknd 8660 1 Seven seven CD cord-010119-t1x9gknd 8660 2 of of IN cord-010119-t1x9gknd 8660 3 299 299 CD cord-010119-t1x9gknd 8660 4 ( ( -LRB- cord-010119-t1x9gknd 8660 5 17 17 CD cord-010119-t1x9gknd 8660 6 ) ) -RRB- cord-010119-t1x9gknd 8660 7 40 40 CD cord-010119-t1x9gknd 8660 8 ( ( -LRB- cord-010119-t1x9gknd 8660 9 24 24 CD cord-010119-t1x9gknd 8660 10 ) ) -RRB- cord-010119-t1x9gknd 8660 11 orders order NNS cord-010119-t1x9gknd 8660 12 were be VBD cord-010119-t1x9gknd 8660 13 for for IN cord-010119-t1x9gknd 8660 14 critically critically RB cord-010119-t1x9gknd 8660 15 low low JJ cord-010119-t1x9gknd 8660 16 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8660 17 ( ( -LRB- cord-010119-t1x9gknd 8660 18 < < XX cord-010119-t1x9gknd 8660 19 50 50 CD cord-010119-t1x9gknd 8660 20 mg mg NNP cord-010119-t1x9gknd 8660 21 / / SYM cord-010119-t1x9gknd 8660 22 dl dl NNP cord-010119-t1x9gknd 8660 23 ) ) -RRB- cord-010119-t1x9gknd 8660 24 and and CC cord-010119-t1x9gknd 8660 25 4 4 CD cord-010119-t1x9gknd 8660 26 of of IN cord-010119-t1x9gknd 8660 27 these these DT cord-010119-t1x9gknd 8660 28 were be VBD cord-010119-t1x9gknd 8660 29 under under RB cord-010119-t1x9gknd 8660 30 - - HYPH cord-010119-t1x9gknd 8660 31 estimated estimate VBN cord-010119-t1x9gknd 8660 32 requests request NNS cord-010119-t1x9gknd 8660 33 and and CC cord-010119-t1x9gknd 8660 34 reached reach VBN cord-010119-t1x9gknd 8660 35 target target NN cord-010119-t1x9gknd 8660 36 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8660 37 with with IN cord-010119-t1x9gknd 8660 38 TMS TMS NNP cord-010119-t1x9gknd 8660 39 's 's POS cord-010119-t1x9gknd 8660 40 estimate estimate NN cord-010119-t1x9gknd 8660 41 and and CC cord-010119-t1x9gknd 8660 42 approval approval NN cord-010119-t1x9gknd 8660 43 of of IN cord-010119-t1x9gknd 8660 44 required require VBN cord-010119-t1x9gknd 8660 45 units unit NNS cord-010119-t1x9gknd 8660 46 to to TO cord-010119-t1x9gknd 8660 47 be be VB cord-010119-t1x9gknd 8660 48 transfused transfuse VBN cord-010119-t1x9gknd 8660 49 . . . cord-010119-t1x9gknd 8661 1 Overall overall RB cord-010119-t1x9gknd 8661 2 most most RBS cord-010119-t1x9gknd 8661 3 frequent frequent JJ cord-010119-t1x9gknd 8661 4 orders order NNS cord-010119-t1x9gknd 8661 5 were be VBD cord-010119-t1x9gknd 8661 6 10 10 CD cord-010119-t1x9gknd 8661 7 and and CC cord-010119-t1x9gknd 8661 8 5 5 CD cord-010119-t1x9gknd 8661 9 units unit NNS cord-010119-t1x9gknd 8661 10 ( ( -LRB- cord-010119-t1x9gknd 8661 11 59.5 59.5 CD cord-010119-t1x9gknd 8661 12 % % NN cord-010119-t1x9gknd 8661 13 and and CC cord-010119-t1x9gknd 8661 14 25 25 CD cord-010119-t1x9gknd 8661 15 % % NN cord-010119-t1x9gknd 8661 16 ) ) -RRB- cord-010119-t1x9gknd 8661 17 i.e. i.e. FW cord-010119-t1x9gknd 8661 18 2 2 CD cord-010119-t1x9gknd 8661 19 and and CC cord-010119-t1x9gknd 8661 20 1 1 CD cord-010119-t1x9gknd 8661 21 pools pool NNS cord-010119-t1x9gknd 8661 22 and and CC cord-010119-t1x9gknd 8661 23 the the DT cord-010119-t1x9gknd 8661 24 most most RBS cord-010119-t1x9gknd 8661 25 frequent frequent JJ cord-010119-t1x9gknd 8661 26 orders order NNS cord-010119-t1x9gknd 8661 27 in in IN cord-010119-t1x9gknd 8661 28 the the DT cord-010119-t1x9gknd 8661 29 disagreement disagreement NN cord-010119-t1x9gknd 8661 30 group group NN cord-010119-t1x9gknd 8661 31 were be VBD cord-010119-t1x9gknd 8661 32 10 10 CD cord-010119-t1x9gknd 8661 33 , , , cord-010119-t1x9gknd 8661 34 1 1 CD cord-010119-t1x9gknd 8661 35 , , , cord-010119-t1x9gknd 8661 36 5 5 CD cord-010119-t1x9gknd 8661 37 and and CC cord-010119-t1x9gknd 8661 38 2 2 CD cord-010119-t1x9gknd 8661 39 units unit NNS cord-010119-t1x9gknd 8661 40 ( ( -LRB- cord-010119-t1x9gknd 8661 41 33 33 CD cord-010119-t1x9gknd 8661 42 % % NN cord-010119-t1x9gknd 8661 43 , , , cord-010119-t1x9gknd 8661 44 20 20 CD cord-010119-t1x9gknd 8661 45 % % NN cord-010119-t1x9gknd 8661 46 , , , cord-010119-t1x9gknd 8661 47 17 17 CD cord-010119-t1x9gknd 8661 48 % % NN cord-010119-t1x9gknd 8661 49 and and CC cord-010119-t1x9gknd 8661 50 16 16 CD cord-010119-t1x9gknd 8661 51 % % NN cord-010119-t1x9gknd 8661 52 ) ) -RRB- cord-010119-t1x9gknd 8661 53 . . . cord-010119-t1x9gknd 8662 1 There there EX cord-010119-t1x9gknd 8662 2 is be VBZ cord-010119-t1x9gknd 8662 3 a a DT cord-010119-t1x9gknd 8662 4 significant significant JJ cord-010119-t1x9gknd 8662 5 difference difference NN cord-010119-t1x9gknd 8662 6 between between IN cord-010119-t1x9gknd 8662 7 agreement agreement NN cord-010119-t1x9gknd 8662 8 and and CC cord-010119-t1x9gknd 8662 9 disagreement disagreement NN cord-010119-t1x9gknd 8662 10 groups group NNS cord-010119-t1x9gknd 8662 11 based base VBN cord-010119-t1x9gknd 8662 12 on on IN cord-010119-t1x9gknd 8662 13 clinical clinical JJ cord-010119-t1x9gknd 8662 14 service service NN cord-010119-t1x9gknd 8662 15 ordering order VBG cord-010119-t1x9gknd 8662 16 the the DT cord-010119-t1x9gknd 8662 17 units unit NNS cord-010119-t1x9gknd 8662 18 ( ( -LRB- cord-010119-t1x9gknd 8662 19 Table table NN cord-010119-t1x9gknd 8662 20 ) ) -RRB- cord-010119-t1x9gknd 8662 21 . . . cord-010119-t1x9gknd 8663 1 Conclusion conclusion NN cord-010119-t1x9gknd 8663 2 : : : cord-010119-t1x9gknd 8664 1 Intervention intervention NN cord-010119-t1x9gknd 8664 2 by by IN cord-010119-t1x9gknd 8664 3 TMS TMS NNP cord-010119-t1x9gknd 8664 4 to to TO cord-010119-t1x9gknd 8664 5 review review VB cord-010119-t1x9gknd 8664 6 and and CC cord-010119-t1x9gknd 8664 7 approve approve VB cord-010119-t1x9gknd 8664 8 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8664 9 orders order NNS cord-010119-t1x9gknd 8664 10 was be VBD cord-010119-t1x9gknd 8664 11 associated associate VBN cord-010119-t1x9gknd 8664 12 with with IN cord-010119-t1x9gknd 8664 13 increased increased JJ cord-010119-t1x9gknd 8664 14 accuracy accuracy NN cord-010119-t1x9gknd 8664 15 of of IN cord-010119-t1x9gknd 8664 16 orders order NNS cord-010119-t1x9gknd 8664 17 and and CC cord-010119-t1x9gknd 8664 18 achievement achievement NN cord-010119-t1x9gknd 8664 19 of of IN cord-010119-t1x9gknd 8664 20 desired desire VBN cord-010119-t1x9gknd 8664 21 target target NN cord-010119-t1x9gknd 8664 22 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8664 23 levels level NNS cord-010119-t1x9gknd 8664 24 . . . cord-010119-t1x9gknd 8665 1 Further further JJ cord-010119-t1x9gknd 8665 2 studies study NNS cord-010119-t1x9gknd 8665 3 are be VBP cord-010119-t1x9gknd 8665 4 needed need VBN cord-010119-t1x9gknd 8665 5 to to TO cord-010119-t1x9gknd 8665 6 develop develop VB cord-010119-t1x9gknd 8665 7 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 8665 8 strategies strategy NNS cord-010119-t1x9gknd 8665 9 for for IN cord-010119-t1x9gknd 8665 10 accurate accurate JJ cord-010119-t1x9gknd 8665 11 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8665 12 dosage dosage NN cord-010119-t1x9gknd 8665 13 . . . cord-010119-t1x9gknd 8666 1 Patient patient JJ cord-010119-t1x9gknd 8666 2 characteristics characteristic NNS cord-010119-t1x9gknd 8666 3 , , , cord-010119-t1x9gknd 8666 4 medical medical JJ cord-010119-t1x9gknd 8666 5 records record NNS cord-010119-t1x9gknd 8666 6 , , , cord-010119-t1x9gknd 8666 7 vitamin vitamin NN cord-010119-t1x9gknd 8666 8 K K NNP cord-010119-t1x9gknd 8666 9 administration administration NN cord-010119-t1x9gknd 8666 10 , , , cord-010119-t1x9gknd 8666 11 and and CC cord-010119-t1x9gknd 8666 12 adverse adverse JJ cord-010119-t1x9gknd 8666 13 events event NNS cord-010119-t1x9gknd 8666 14 , , , cord-010119-t1x9gknd 8666 15 were be VBD cord-010119-t1x9gknd 8666 16 collected collect VBN cord-010119-t1x9gknd 8666 17 ( ( -LRB- cord-010119-t1x9gknd 8666 18 Table table NN cord-010119-t1x9gknd 8666 19 ) ) -RRB- cord-010119-t1x9gknd 8666 20 . . . cord-010119-t1x9gknd 8667 1 Results/ Results/ . cord-010119-t1x9gknd 8668 1 Finding finding NN cord-010119-t1x9gknd 8668 2 : : : cord-010119-t1x9gknd 8669 1 The the DT cord-010119-t1x9gknd 8669 2 average average JJ cord-010119-t1x9gknd 8669 3 pre pre JJ cord-010119-t1x9gknd 8669 4 - - JJ cord-010119-t1x9gknd 8669 5 transfusion transfusion NN cord-010119-t1x9gknd 8669 6 INR INR NNP cord-010119-t1x9gknd 8669 7 was be VBD cord-010119-t1x9gknd 8669 8 2.36 2.36 CD cord-010119-t1x9gknd 8669 9 and and CC cord-010119-t1x9gknd 8669 10 posttransfusion posttransfusion NN cord-010119-t1x9gknd 8669 11 was be VBD cord-010119-t1x9gknd 8669 12 1.91 1.91 CD cord-010119-t1x9gknd 8669 13 . . . cord-010119-t1x9gknd 8670 1 Only only RB cord-010119-t1x9gknd 8670 2 22 22 CD cord-010119-t1x9gknd 8670 3 % % NN cord-010119-t1x9gknd 8670 4 of of IN cord-010119-t1x9gknd 8670 5 patients patient NNS cord-010119-t1x9gknd 8670 6 had have VBD cord-010119-t1x9gknd 8670 7 their -PRON- PRP$ cord-010119-t1x9gknd 8670 8 INR INR NNP cord-010119-t1x9gknd 8670 9 corrected correct VBD cord-010119-t1x9gknd 8670 10 to to IN cord-010119-t1x9gknd 8670 11 1.5 1.5 CD cord-010119-t1x9gknd 8670 12 , , , cord-010119-t1x9gknd 8670 13 while while IN cord-010119-t1x9gknd 8670 14 28 28 CD cord-010119-t1x9gknd 8670 15 % % NN cord-010119-t1x9gknd 8670 16 had have VBD cord-010119-t1x9gknd 8670 17 no no DT cord-010119-t1x9gknd 8670 18 change change NN cord-010119-t1x9gknd 8670 19 , , , cord-010119-t1x9gknd 8670 20 or or CC cord-010119-t1x9gknd 8670 21 had have VBD cord-010119-t1x9gknd 8670 22 increased increase VBN cord-010119-t1x9gknd 8670 23 INR INR NNP cord-010119-t1x9gknd 8670 24 . . . cord-010119-t1x9gknd 8671 1 ( ( -LRB- cord-010119-t1x9gknd 8671 2 Table table NN cord-010119-t1x9gknd 8671 3 ) ) -RRB- cord-010119-t1x9gknd 8671 4 . . . cord-010119-t1x9gknd 8672 1 The the DT cord-010119-t1x9gknd 8672 2 majority majority NN cord-010119-t1x9gknd 8672 3 ( ( -LRB- cord-010119-t1x9gknd 8672 4 67 67 CD cord-010119-t1x9gknd 8672 5 % % NN cord-010119-t1x9gknd 8672 6 ) ) -RRB- cord-010119-t1x9gknd 8672 7 of of IN cord-010119-t1x9gknd 8672 8 patients patient NNS cord-010119-t1x9gknd 8672 9 received receive VBD cord-010119-t1x9gknd 8672 10 2 2 CD cord-010119-t1x9gknd 8672 11 units unit NNS cord-010119-t1x9gknd 8672 12 of of IN cord-010119-t1x9gknd 8672 13 plasma plasma NN cord-010119-t1x9gknd 8672 14 . . . cord-010119-t1x9gknd 8673 1 The the DT cord-010119-t1x9gknd 8673 2 mean mean JJ cord-010119-t1x9gknd 8673 3 plasma plasma NN cord-010119-t1x9gknd 8673 4 dose dose NN cord-010119-t1x9gknd 8673 5 was be VBD cord-010119-t1x9gknd 8673 6 6 6 CD cord-010119-t1x9gknd 8673 7 mL ml NN cord-010119-t1x9gknd 8673 8 / / SYM cord-010119-t1x9gknd 8673 9 kg kg NN cord-010119-t1x9gknd 8673 10 . . . cord-010119-t1x9gknd 8674 1 There there EX cord-010119-t1x9gknd 8674 2 were be VBD cord-010119-t1x9gknd 8674 3 4 4 CD cord-010119-t1x9gknd 8674 4 transfusion transfusion NN cord-010119-t1x9gknd 8674 5 reactions reaction NNS cord-010119-t1x9gknd 8674 6 reported report VBN cord-010119-t1x9gknd 8674 7 , , , cord-010119-t1x9gknd 8674 8 1 1 CD cord-010119-t1x9gknd 8674 9 non non JJ cord-010119-t1x9gknd 8674 10 - - JJ cord-010119-t1x9gknd 8674 11 hemolytic hemolytic JJ cord-010119-t1x9gknd 8674 12 and and CC cord-010119-t1x9gknd 8674 13 3 3 CD cord-010119-t1x9gknd 8674 14 transfusion transfusion NN cord-010119-t1x9gknd 8674 15 associated associate VBD cord-010119-t1x9gknd 8674 16 circulatory circulatory JJ cord-010119-t1x9gknd 8674 17 overload overload NN cord-010119-t1x9gknd 8674 18 reactions reaction NNS cord-010119-t1x9gknd 8674 19 in in IN cord-010119-t1x9gknd 8674 20 which which WDT cord-010119-t1x9gknd 8674 21 1 1 CD cord-010119-t1x9gknd 8674 22 required require VBD cord-010119-t1x9gknd 8674 23 admission admission NN cord-010119-t1x9gknd 8674 24 to to IN cord-010119-t1x9gknd 8674 25 the the DT cord-010119-t1x9gknd 8674 26 ICU ICU NNP cord-010119-t1x9gknd 8674 27 . . . cord-010119-t1x9gknd 8675 1 Two two CD cord-010119-t1x9gknd 8675 2 patients patient NNS cord-010119-t1x9gknd 8675 3 experienced experience VBD cord-010119-t1x9gknd 8675 4 bleeding bleed VBG cord-010119-t1x9gknd 8675 5 during during IN cord-010119-t1x9gknd 8675 6 IR IR NNP cord-010119-t1x9gknd 8675 7 procedures procedure NNS cord-010119-t1x9gknd 8675 8 ( ( -LRB- cord-010119-t1x9gknd 8675 9 TIPS tip NNS cord-010119-t1x9gknd 8675 10 ) ) -RRB- cord-010119-t1x9gknd 8675 11 and and CC cord-010119-t1x9gknd 8675 12 1 1 CD cord-010119-t1x9gknd 8675 13 developed develop VBD cord-010119-t1x9gknd 8675 14 a a DT cord-010119-t1x9gknd 8675 15 hematoma hematoma NN cord-010119-t1x9gknd 8675 16 ( ( -LRB- cord-010119-t1x9gknd 8675 17 tunneled tunnel VBN cord-010119-t1x9gknd 8675 18 central central JJ cord-010119-t1x9gknd 8675 19 line line NN cord-010119-t1x9gknd 8675 20 ) ) -RRB- cord-010119-t1x9gknd 8675 21 . . . cord-010119-t1x9gknd 8676 1 The the DT cord-010119-t1x9gknd 8676 2 median median NN cord-010119-t1x9gknd 8676 3 of of IN cord-010119-t1x9gknd 8676 4 INR INR NNP cord-010119-t1x9gknd 8676 5 correction correction NN cord-010119-t1x9gknd 8676 6 in in IN cord-010119-t1x9gknd 8676 7 this this DT cord-010119-t1x9gknd 8676 8 study study NN cord-010119-t1x9gknd 8676 9 was be VBD cord-010119-t1x9gknd 8676 10 1.9 1.9 CD cord-010119-t1x9gknd 8676 11 with with IN cord-010119-t1x9gknd 8676 12 no no DT cord-010119-t1x9gknd 8676 13 relationship relationship NN cord-010119-t1x9gknd 8676 14 to to IN cord-010119-t1x9gknd 8676 15 the the DT cord-010119-t1x9gknd 8676 16 number number NN cord-010119-t1x9gknd 8676 17 of of IN cord-010119-t1x9gknd 8676 18 units unit NNS cord-010119-t1x9gknd 8676 19 of of IN cord-010119-t1x9gknd 8676 20 plasma plasma NN cord-010119-t1x9gknd 8676 21 transfused transfuse VBN cord-010119-t1x9gknd 8676 22 and/or and/or CC cord-010119-t1x9gknd 8676 23 if if IN cord-010119-t1x9gknd 8676 24 vitamin vitamin NN cord-010119-t1x9gknd 8676 25 K K NNP cord-010119-t1x9gknd 8676 26 was be VBD cord-010119-t1x9gknd 8676 27 administered administer VBN cord-010119-t1x9gknd 8676 28 . . . cord-010119-t1x9gknd 8677 1 This this DT cord-010119-t1x9gknd 8677 2 study study NN cord-010119-t1x9gknd 8677 3 suggests suggest VBZ cord-010119-t1x9gknd 8677 4 it -PRON- PRP cord-010119-t1x9gknd 8677 5 may may MD cord-010119-t1x9gknd 8677 6 not not RB cord-010119-t1x9gknd 8677 7 be be VB cord-010119-t1x9gknd 8677 8 beneficial beneficial JJ cord-010119-t1x9gknd 8677 9 and and CC cord-010119-t1x9gknd 8677 10 may may MD cord-010119-t1x9gknd 8677 11 be be VB cord-010119-t1x9gknd 8677 12 harmful harmful JJ cord-010119-t1x9gknd 8677 13 to to TO cord-010119-t1x9gknd 8677 14 transfuse transfuse VB cord-010119-t1x9gknd 8677 15 plasma plasma NN cord-010119-t1x9gknd 8677 16 for for IN cord-010119-t1x9gknd 8677 17 correction correction NN cord-010119-t1x9gknd 8677 18 when when WRB cord-010119-t1x9gknd 8677 19 INR INR NNP cord-010119-t1x9gknd 8677 20 is be VBZ cord-010119-t1x9gknd 8677 21 1.9 1.9 CD cord-010119-t1x9gknd 8677 22 . . . cord-010119-t1x9gknd 8678 1 Randomized randomized JJ cord-010119-t1x9gknd 8678 2 trials trial NNS cord-010119-t1x9gknd 8678 3 are be VBP cord-010119-t1x9gknd 8678 4 needed need VBN cord-010119-t1x9gknd 8678 5 to to TO cord-010119-t1x9gknd 8678 6 assess assess VB cord-010119-t1x9gknd 8678 7 whether whether IN cord-010119-t1x9gknd 8678 8 the the DT cord-010119-t1x9gknd 8678 9 INR INR NNP cord-010119-t1x9gknd 8678 10 is be VBZ cord-010119-t1x9gknd 8678 11 a a DT cord-010119-t1x9gknd 8678 12 rational rational JJ cord-010119-t1x9gknd 8678 13 tool tool NN cord-010119-t1x9gknd 8678 14 to to TO cord-010119-t1x9gknd 8678 15 measure measure VB cord-010119-t1x9gknd 8678 16 bleeding bleed VBG cord-010119-t1x9gknd 8678 17 risk risk NN cord-010119-t1x9gknd 8678 18 , , , cord-010119-t1x9gknd 8678 19 and and CC cord-010119-t1x9gknd 8678 20 whether whether IN cord-010119-t1x9gknd 8678 21 prophylactic prophylactic JJ cord-010119-t1x9gknd 8678 22 treatment treatment NN cord-010119-t1x9gknd 8678 23 with with IN cord-010119-t1x9gknd 8678 24 plasma plasma NN cord-010119-t1x9gknd 8678 25 yields yield NNS cord-010119-t1x9gknd 8678 26 any any DT cord-010119-t1x9gknd 8678 27 benefit benefit NN cord-010119-t1x9gknd 8678 28 . . . cord-010119-t1x9gknd 8679 1 3 3 CD cord-010119-t1x9gknd 8679 2 of of IN cord-010119-t1x9gknd 8679 3 the the DT cord-010119-t1x9gknd 8679 4 111 111 CD cord-010119-t1x9gknd 8679 5 patients patient NNS cord-010119-t1x9gknd 8679 6 experienced experience VBD cord-010119-t1x9gknd 8679 7 bleeding bleeding JJ cord-010119-t1x9gknd 8679 8 complications complication NNS cord-010119-t1x9gknd 8679 9 indicating indicate VBG cord-010119-t1x9gknd 8679 10 that that IN cord-010119-t1x9gknd 8679 11 INR INR NNP cord-010119-t1x9gknd 8679 12 of of IN cord-010119-t1x9gknd 8679 13 1.9 1.9 CD cord-010119-t1x9gknd 8679 14 may may MD cord-010119-t1x9gknd 8679 15 be be VB cord-010119-t1x9gknd 8679 16 considered consider VBN cord-010119-t1x9gknd 8679 17 safe safe JJ cord-010119-t1x9gknd 8679 18 in in IN cord-010119-t1x9gknd 8679 19 some some DT cord-010119-t1x9gknd 8679 20 lower low JJR cord-010119-t1x9gknd 8679 21 risk risk NN cord-010119-t1x9gknd 8679 22 procedures procedure NNS cord-010119-t1x9gknd 8679 23 . . . cord-010119-t1x9gknd 8680 1 Current current JJ cord-010119-t1x9gknd 8680 2 practices practice NNS cord-010119-t1x9gknd 8680 3 may may MD cord-010119-t1x9gknd 8680 4 provide provide VB cord-010119-t1x9gknd 8680 5 little little JJ cord-010119-t1x9gknd 8680 6 or or CC cord-010119-t1x9gknd 8680 7 no no DT cord-010119-t1x9gknd 8680 8 benefit benefit NN cord-010119-t1x9gknd 8680 9 , , , cord-010119-t1x9gknd 8680 10 with with IN cord-010119-t1x9gknd 8680 11 substantial substantial JJ cord-010119-t1x9gknd 8680 12 risk risk NN cord-010119-t1x9gknd 8680 13 of of IN cord-010119-t1x9gknd 8680 14 life life NN cord-010119-t1x9gknd 8680 15 threatening threaten VBG cord-010119-t1x9gknd 8680 16 complications complication NNS cord-010119-t1x9gknd 8680 17 . . . cord-010119-t1x9gknd 8681 1 Background Background NNP cord-010119-t1x9gknd 8681 2 / / SYM cord-010119-t1x9gknd 8681 3 Case Case NNP cord-010119-t1x9gknd 8681 4 Studies Studies NNPS cord-010119-t1x9gknd 8681 5 : : : cord-010119-t1x9gknd 8682 1 Group group NN cord-010119-t1x9gknd 8682 2 AB AB NNP cord-010119-t1x9gknd 8682 3 plasma plasma NN cord-010119-t1x9gknd 8682 4 , , , cord-010119-t1x9gknd 8682 5 which which WDT cord-010119-t1x9gknd 8682 6 lacks lack VBZ cord-010119-t1x9gknd 8682 7 anti anti JJ cord-010119-t1x9gknd 8682 8 - - JJ cord-010119-t1x9gknd 8682 9 A a JJ cord-010119-t1x9gknd 8682 10 and and CC cord-010119-t1x9gknd 8682 11 anti anti JJ cord-010119-t1x9gknd 8682 12 - - JJ cord-010119-t1x9gknd 8682 13 B b JJ cord-010119-t1x9gknd 8682 14 antibodies antibody NNS cord-010119-t1x9gknd 8682 15 , , , cord-010119-t1x9gknd 8682 16 is be VBZ cord-010119-t1x9gknd 8682 17 considered consider VBN cord-010119-t1x9gknd 8682 18 to to TO cord-010119-t1x9gknd 8682 19 be be VB cord-010119-t1x9gknd 8682 20 the the DT cord-010119-t1x9gknd 8682 21 universal universal JJ cord-010119-t1x9gknd 8682 22 plasma plasma NN cord-010119-t1x9gknd 8682 23 donor donor NN cord-010119-t1x9gknd 8682 24 and and CC cord-010119-t1x9gknd 8682 25 is be VBZ cord-010119-t1x9gknd 8682 26 used use VBN cord-010119-t1x9gknd 8682 27 in in IN cord-010119-t1x9gknd 8682 28 the the DT cord-010119-t1x9gknd 8682 29 emergency emergency NN cord-010119-t1x9gknd 8682 30 setting set VBG cord-010119-t1x9gknd 8682 31 before before IN cord-010119-t1x9gknd 8682 32 the the DT cord-010119-t1x9gknd 8682 33 patient patient NN cord-010119-t1x9gknd 8682 34 's 's POS cord-010119-t1x9gknd 8682 35 blood blood NN cord-010119-t1x9gknd 8682 36 group group NN cord-010119-t1x9gknd 8682 37 is be VBZ cord-010119-t1x9gknd 8682 38 available available JJ cord-010119-t1x9gknd 8682 39 . . . cord-010119-t1x9gknd 8683 1 Approximately approximately RB cord-010119-t1x9gknd 8683 2 4 4 CD cord-010119-t1x9gknd 8683 3 % % NN cord-010119-t1x9gknd 8683 4 of of IN cord-010119-t1x9gknd 8683 5 the the DT cord-010119-t1x9gknd 8683 6 population population NN cord-010119-t1x9gknd 8683 7 is be VBZ cord-010119-t1x9gknd 8683 8 group group NN cord-010119-t1x9gknd 8683 9 AB AB NNP cord-010119-t1x9gknd 8683 10 , , , cord-010119-t1x9gknd 8683 11 which which WDT cord-010119-t1x9gknd 8683 12 limits limit VBZ cord-010119-t1x9gknd 8683 13 the the DT cord-010119-t1x9gknd 8683 14 available available JJ cord-010119-t1x9gknd 8683 15 inventory inventory NN cord-010119-t1x9gknd 8683 16 of of IN cord-010119-t1x9gknd 8683 17 group group NN cord-010119-t1x9gknd 8683 18 AB ab NN cord-010119-t1x9gknd 8683 19 plasma plasma NN cord-010119-t1x9gknd 8683 20 . . . cord-010119-t1x9gknd 8684 1 Of of IN cord-010119-t1x9gknd 8684 2 group group NN cord-010119-t1x9gknd 8684 3 AB AB NNP cord-010119-t1x9gknd 8684 4 population population NN cord-010119-t1x9gknd 8684 5 , , , cord-010119-t1x9gknd 8684 6 only only RB cord-010119-t1x9gknd 8684 7 plasma plasma NN cord-010119-t1x9gknd 8684 8 from from IN cord-010119-t1x9gknd 8684 9 male male JJ cord-010119-t1x9gknd 8684 10 donors donor NNS cord-010119-t1x9gknd 8684 11 are be VBP cord-010119-t1x9gknd 8684 12 considered consider VBN cord-010119-t1x9gknd 8684 13 suitable suitable JJ cord-010119-t1x9gknd 8684 14 for for IN cord-010119-t1x9gknd 8684 15 transfusion transfusion NN cord-010119-t1x9gknd 8684 16 since since IN cord-010119-t1x9gknd 8684 17 females female NNS cord-010119-t1x9gknd 8684 18 , , , cord-010119-t1x9gknd 8684 19 especially especially RB cord-010119-t1x9gknd 8684 20 multiparous multiparous JJ cord-010119-t1x9gknd 8684 21 female female JJ cord-010119-t1x9gknd 8684 22 donors donor NNS cord-010119-t1x9gknd 8684 23 , , , cord-010119-t1x9gknd 8684 24 have have VBP cord-010119-t1x9gknd 8684 25 a a DT cord-010119-t1x9gknd 8684 26 greater great JJR cord-010119-t1x9gknd 8684 27 propensity propensity NN cord-010119-t1x9gknd 8684 28 to to TO cord-010119-t1x9gknd 8684 29 develop develop VB cord-010119-t1x9gknd 8684 30 antibodies antibody NNS cord-010119-t1x9gknd 8684 31 that that WDT cord-010119-t1x9gknd 8684 32 can can MD cord-010119-t1x9gknd 8684 33 cause cause VB cord-010119-t1x9gknd 8684 34 transfusion transfusion NN cord-010119-t1x9gknd 8684 35 related relate VBN cord-010119-t1x9gknd 8684 36 acute acute JJ cord-010119-t1x9gknd 8684 37 lung lung NN cord-010119-t1x9gknd 8684 38 injury injury NN cord-010119-t1x9gknd 8684 39 ( ( -LRB- cord-010119-t1x9gknd 8684 40 TRALI TRALI NNP cord-010119-t1x9gknd 8684 41 ) ) -RRB- cord-010119-t1x9gknd 8684 42 . . . cord-010119-t1x9gknd 8685 1 This this DT cord-010119-t1x9gknd 8685 2 makes make VBZ cord-010119-t1x9gknd 8685 3 type type NN cord-010119-t1x9gknd 8685 4 AB ab NN cord-010119-t1x9gknd 8685 5 plasma plasma NN cord-010119-t1x9gknd 8685 6 a a DT cord-010119-t1x9gknd 8685 7 limited limited JJ cord-010119-t1x9gknd 8685 8 resource resource NN cord-010119-t1x9gknd 8685 9 . . . cord-010119-t1x9gknd 8686 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8686 2 hospital hospital NN cord-010119-t1x9gknd 8686 3 is be VBZ cord-010119-t1x9gknd 8686 4 a a DT cord-010119-t1x9gknd 8686 5 level level JJ cord-010119-t1x9gknd 8686 6 one one CD cord-010119-t1x9gknd 8686 7 trauma trauma NN cord-010119-t1x9gknd 8686 8 center center NN cord-010119-t1x9gknd 8686 9 , , , cord-010119-t1x9gknd 8686 10 where where WRB cord-010119-t1x9gknd 8686 11 a a DT cord-010119-t1x9gknd 8686 12 significant significant JJ cord-010119-t1x9gknd 8686 13 amount amount NN cord-010119-t1x9gknd 8686 14 of of IN cord-010119-t1x9gknd 8686 15 plasma plasma NN cord-010119-t1x9gknd 8686 16 transfusion transfusion NN cord-010119-t1x9gknd 8686 17 is be VBZ cord-010119-t1x9gknd 8686 18 required require VBN cord-010119-t1x9gknd 8686 19 for for IN cord-010119-t1x9gknd 8686 20 severely severely RB cord-010119-t1x9gknd 8686 21 bleeding bleed VBG cord-010119-t1x9gknd 8686 22 patients patient NNS cord-010119-t1x9gknd 8686 23 before before IN cord-010119-t1x9gknd 8686 24 their -PRON- PRP$ cord-010119-t1x9gknd 8686 25 blood blood NN cord-010119-t1x9gknd 8686 26 type type NN cord-010119-t1x9gknd 8686 27 is be VBZ cord-010119-t1x9gknd 8686 28 known know VBN cord-010119-t1x9gknd 8686 29 . . . cord-010119-t1x9gknd 8687 1 Group group NN cord-010119-t1x9gknd 8687 2 O o NN cord-010119-t1x9gknd 8687 3 individuals individual NNS cord-010119-t1x9gknd 8687 4 make make VBP cord-010119-t1x9gknd 8687 5 up up RP cord-010119-t1x9gknd 8687 6 45 45 CD cord-010119-t1x9gknd 8687 7 % % NN cord-010119-t1x9gknd 8687 8 of of IN cord-010119-t1x9gknd 8687 9 the the DT cord-010119-t1x9gknd 8687 10 population population NN cord-010119-t1x9gknd 8687 11 and and CC cord-010119-t1x9gknd 8687 12 have have VBP cord-010119-t1x9gknd 8687 13 no no DT cord-010119-t1x9gknd 8687 14 A a NN cord-010119-t1x9gknd 8687 15 or or CC cord-010119-t1x9gknd 8687 16 B b NN cord-010119-t1x9gknd 8687 17 antigens antigen NNS cord-010119-t1x9gknd 8687 18 on on IN cord-010119-t1x9gknd 8687 19 their -PRON- PRP$ cord-010119-t1x9gknd 8687 20 cells cell NNS cord-010119-t1x9gknd 8687 21 . . . cord-010119-t1x9gknd 8688 1 Group Group NNP cord-010119-t1x9gknd 8688 2 A A NNP cord-010119-t1x9gknd 8688 3 is be VBZ cord-010119-t1x9gknd 8688 4 the the DT cord-010119-t1x9gknd 8688 5 second second JJ cord-010119-t1x9gknd 8688 6 most most RBS cord-010119-t1x9gknd 8688 7 prevalent prevalent JJ cord-010119-t1x9gknd 8688 8 blood blood NN cord-010119-t1x9gknd 8688 9 group group NN cord-010119-t1x9gknd 8688 10 in in IN cord-010119-t1x9gknd 8688 11 the the DT cord-010119-t1x9gknd 8688 12 US US NNP cord-010119-t1x9gknd 8688 13 population population NN cord-010119-t1x9gknd 8688 14 ( ( -LRB- cord-010119-t1x9gknd 8688 15 40 40 CD cord-010119-t1x9gknd 8688 16 % % NN cord-010119-t1x9gknd 8688 17 ) ) -RRB- cord-010119-t1x9gknd 8688 18 and and CC cord-010119-t1x9gknd 8688 19 has have VBZ cord-010119-t1x9gknd 8688 20 no no DT cord-010119-t1x9gknd 8688 21 B b NN cord-010119-t1x9gknd 8688 22 antigen antigen NN cord-010119-t1x9gknd 8688 23 on on IN cord-010119-t1x9gknd 8688 24 their -PRON- PRP$ cord-010119-t1x9gknd 8688 25 cells cell NNS cord-010119-t1x9gknd 8688 26 . . . cord-010119-t1x9gknd 8689 1 So so RB cord-010119-t1x9gknd 8689 2 , , , cord-010119-t1x9gknd 8689 3 group group NN cord-010119-t1x9gknd 8689 4 A a DT cord-010119-t1x9gknd 8689 5 plasma plasma NN cord-010119-t1x9gknd 8689 6 is be VBZ cord-010119-t1x9gknd 8689 7 compatible compatible JJ cord-010119-t1x9gknd 8689 8 with with IN cord-010119-t1x9gknd 8689 9 both both DT cord-010119-t1x9gknd 8689 10 group group NN cord-010119-t1x9gknd 8689 11 O o NN cord-010119-t1x9gknd 8689 12 and and CC cord-010119-t1x9gknd 8689 13 A a DT cord-010119-t1x9gknd 8689 14 patients patient NNS cord-010119-t1x9gknd 8689 15 , , , cord-010119-t1x9gknd 8689 16 approximately approximately RB cord-010119-t1x9gknd 8689 17 85 85 CD cord-010119-t1x9gknd 8689 18 % % NN cord-010119-t1x9gknd 8689 19 of of IN cord-010119-t1x9gknd 8689 20 the the DT cord-010119-t1x9gknd 8689 21 patient patient JJ cord-010119-t1x9gknd 8689 22 population population NN cord-010119-t1x9gknd 8689 23 . . . cord-010119-t1x9gknd 8690 1 Before before IN cord-010119-t1x9gknd 8690 2 patient patient NN cord-010119-t1x9gknd 8690 3 's 's POS cord-010119-t1x9gknd 8690 4 blood blood NN cord-010119-t1x9gknd 8690 5 type type NN cord-010119-t1x9gknd 8690 6 is be VBZ cord-010119-t1x9gknd 8690 7 known know VBN cord-010119-t1x9gknd 8690 8 , , , cord-010119-t1x9gknd 8690 9 type type VB cord-010119-t1x9gknd 8690 10 O o NN cord-010119-t1x9gknd 8690 11 red red JJ cord-010119-t1x9gknd 8690 12 cell cell NN cord-010119-t1x9gknd 8690 13 units unit NNS cord-010119-t1x9gknd 8690 14 are be VBP cord-010119-t1x9gknd 8690 15 transfused transfuse VBN cord-010119-t1x9gknd 8690 16 with with IN cord-010119-t1x9gknd 8690 17 A a DT cord-010119-t1x9gknd 8690 18 plasma plasma NN cord-010119-t1x9gknd 8690 19 , , , cord-010119-t1x9gknd 8690 20 which which WDT cord-010119-t1x9gknd 8690 21 decreases decrease VBZ cord-010119-t1x9gknd 8690 22 the the DT cord-010119-t1x9gknd 8690 23 chance chance NN cord-010119-t1x9gknd 8690 24 of of IN cord-010119-t1x9gknd 8690 25 hemolysis hemolysis NN cord-010119-t1x9gknd 8690 26 . . . cord-010119-t1x9gknd 8691 1 To to TO cord-010119-t1x9gknd 8691 2 conserve conserve VB cord-010119-t1x9gknd 8691 3 AB AB NNP cord-010119-t1x9gknd 8691 4 plasma plasma NN cord-010119-t1x9gknd 8691 5 , , , cord-010119-t1x9gknd 8691 6 we -PRON- PRP cord-010119-t1x9gknd 8691 7 instituted institute VBD cord-010119-t1x9gknd 8691 8 a a DT cord-010119-t1x9gknd 8691 9 policy policy NN cord-010119-t1x9gknd 8691 10 effective effective JJ cord-010119-t1x9gknd 8691 11 July July NNP cord-010119-t1x9gknd 8691 12 1 1 CD cord-010119-t1x9gknd 8691 13 , , , cord-010119-t1x9gknd 8691 14 2014 2014 CD cord-010119-t1x9gknd 8691 15 as as IN cord-010119-t1x9gknd 8691 16 follows follow VBZ cord-010119-t1x9gknd 8691 17 : : : cord-010119-t1x9gknd 8691 18 2 2 CD cord-010119-t1x9gknd 8691 19 units unit NNS cord-010119-t1x9gknd 8691 20 of of IN cord-010119-t1x9gknd 8691 21 group group NN cord-010119-t1x9gknd 8691 22 A a DT cord-010119-t1x9gknd 8691 23 plasma plasma NN cord-010119-t1x9gknd 8691 24 and and CC cord-010119-t1x9gknd 8691 25 3 3 CD cord-010119-t1x9gknd 8691 26 units unit NNS cord-010119-t1x9gknd 8691 27 of of IN cord-010119-t1x9gknd 8691 28 group group NN cord-010119-t1x9gknd 8691 29 AB ab NN cord-010119-t1x9gknd 8691 30 plasma plasma NN cord-010119-t1x9gknd 8691 31 is be VBZ cord-010119-t1x9gknd 8691 32 provided provide VBN cord-010119-t1x9gknd 8691 33 for for IN cord-010119-t1x9gknd 8691 34 the the DT cord-010119-t1x9gknd 8691 35 Massive massive JJ cord-010119-t1x9gknd 8691 36 transfusion transfusion NN cord-010119-t1x9gknd 8691 37 protocol protocol NN cord-010119-t1x9gknd 8691 38 ( ( -LRB- cord-010119-t1x9gknd 8691 39 MTP MTP NNP cord-010119-t1x9gknd 8691 40 ) ) -RRB- cord-010119-t1x9gknd 8691 41 along along IN cord-010119-t1x9gknd 8691 42 with with IN cord-010119-t1x9gknd 8691 43 5 5 CD cord-010119-t1x9gknd 8691 44 units unit NNS cord-010119-t1x9gknd 8691 45 of of IN cord-010119-t1x9gknd 8691 46 O o NN cord-010119-t1x9gknd 8691 47 negative negative JJ cord-010119-t1x9gknd 8691 48 RBC RBC NNP cord-010119-t1x9gknd 8691 49 until until IN cord-010119-t1x9gknd 8691 50 patient patient JJ cord-010119-t1x9gknd 8691 51 blood blood NN cord-010119-t1x9gknd 8691 52 type type NN cord-010119-t1x9gknd 8691 53 is be VBZ cord-010119-t1x9gknd 8691 54 known know VBN cord-010119-t1x9gknd 8691 55 . . . cord-010119-t1x9gknd 8692 1 Study Study NNP cord-010119-t1x9gknd 8692 2 Design Design NNP cord-010119-t1x9gknd 8692 3 / / SYM cord-010119-t1x9gknd 8692 4 Method method NN cord-010119-t1x9gknd 8692 5 : : : cord-010119-t1x9gknd 8693 1 This this DT cord-010119-t1x9gknd 8693 2 prospective prospective JJ cord-010119-t1x9gknd 8693 3 study study NN cord-010119-t1x9gknd 8693 4 is be VBZ cord-010119-t1x9gknd 8693 5 designed design VBN cord-010119-t1x9gknd 8693 6 to to TO cord-010119-t1x9gknd 8693 7 monitor monitor VB cord-010119-t1x9gknd 8693 8 the the DT cord-010119-t1x9gknd 8693 9 use use NN cord-010119-t1x9gknd 8693 10 of of IN cord-010119-t1x9gknd 8693 11 group group NN cord-010119-t1x9gknd 8693 12 A a DT cord-010119-t1x9gknd 8693 13 plasma plasma NN cord-010119-t1x9gknd 8693 14 in in IN cord-010119-t1x9gknd 8693 15 MTPs mtp NNS cord-010119-t1x9gknd 8693 16 at at IN cord-010119-t1x9gknd 8693 17 our -PRON- PRP$ cord-010119-t1x9gknd 8693 18 institution institution NN cord-010119-t1x9gknd 8693 19 and and CC cord-010119-t1x9gknd 8693 20 to to TO cord-010119-t1x9gknd 8693 21 evaluate evaluate VB cord-010119-t1x9gknd 8693 22 the the DT cord-010119-t1x9gknd 8693 23 risk risk NN cord-010119-t1x9gknd 8693 24 and and CC cord-010119-t1x9gknd 8693 25 severity severity NN cord-010119-t1x9gknd 8693 26 of of IN cord-010119-t1x9gknd 8693 27 hemolysis hemolysis NN cord-010119-t1x9gknd 8693 28 in in IN cord-010119-t1x9gknd 8693 29 patients patient NNS cord-010119-t1x9gknd 8693 30 transfused transfuse VBN cord-010119-t1x9gknd 8693 31 with with IN cord-010119-t1x9gknd 8693 32 incompatible incompatible JJ cord-010119-t1x9gknd 8693 33 plasma plasma NN cord-010119-t1x9gknd 8693 34 . . . cord-010119-t1x9gknd 8694 1 Direct direct JJ cord-010119-t1x9gknd 8694 2 antiglobulin antiglobulin NN cord-010119-t1x9gknd 8694 3 test test NN cord-010119-t1x9gknd 8694 4 ( ( -LRB- cord-010119-t1x9gknd 8694 5 DAT DAT NNP cord-010119-t1x9gknd 8694 6 ) ) -RRB- cord-010119-t1x9gknd 8694 7 is be VBZ cord-010119-t1x9gknd 8694 8 performed perform VBN cord-010119-t1x9gknd 8694 9 if if IN cord-010119-t1x9gknd 8694 10 patient patient NN cord-010119-t1x9gknd 8694 11 received receive VBD cord-010119-t1x9gknd 8694 12 incompatible incompatible JJ cord-010119-t1x9gknd 8694 13 plasma plasma NN cord-010119-t1x9gknd 8694 14 . . . cord-010119-t1x9gknd 8695 1 If if IN cord-010119-t1x9gknd 8695 2 DAT DAT NNP cord-010119-t1x9gknd 8695 3 is be VBZ cord-010119-t1x9gknd 8695 4 positive positive JJ cord-010119-t1x9gknd 8695 5 , , , cord-010119-t1x9gknd 8695 6 lactate lactate NN cord-010119-t1x9gknd 8695 7 dehydrogenase dehydrogenase NN cord-010119-t1x9gknd 8695 8 ( ( -LRB- cord-010119-t1x9gknd 8695 9 LDH LDH NNP cord-010119-t1x9gknd 8695 10 ) ) -RRB- cord-010119-t1x9gknd 8695 11 , , , cord-010119-t1x9gknd 8695 12 haptoglobin haptoglobin NN cord-010119-t1x9gknd 8695 13 and and CC cord-010119-t1x9gknd 8695 14 bilirubin bilirubin NN cord-010119-t1x9gknd 8695 15 levels level NNS cord-010119-t1x9gknd 8695 16 are be VBP cord-010119-t1x9gknd 8695 17 obtained obtain VBN cord-010119-t1x9gknd 8695 18 to to TO cord-010119-t1x9gknd 8695 19 detect detect VB cord-010119-t1x9gknd 8695 20 possible possible JJ cord-010119-t1x9gknd 8695 21 hemolytic hemolytic JJ cord-010119-t1x9gknd 8695 22 transfusion transfusion NN cord-010119-t1x9gknd 8695 23 reaction reaction NN cord-010119-t1x9gknd 8695 24 . . . cord-010119-t1x9gknd 8696 1 Results/ Results/ . cord-010119-t1x9gknd 8697 1 Finding find VBG cord-010119-t1x9gknd 8698 1 : : : cord-010119-t1x9gknd 8698 2 We -PRON- PRP cord-010119-t1x9gknd 8698 3 reviewed review VBD cord-010119-t1x9gknd 8698 4 235 235 CD cord-010119-t1x9gknd 8698 5 MTPs mtp NNS cord-010119-t1x9gknd 8698 6 at at IN cord-010119-t1x9gknd 8698 7 our -PRON- PRP$ cord-010119-t1x9gknd 8698 8 institution institution NN cord-010119-t1x9gknd 8698 9 between between IN cord-010119-t1x9gknd 8698 10 July July NNP cord-010119-t1x9gknd 8698 11 2014 2014 CD cord-010119-t1x9gknd 8698 12 and and CC cord-010119-t1x9gknd 8698 13 March March NNP cord-010119-t1x9gknd 8698 14 2017 2017 CD cord-010119-t1x9gknd 8698 15 . . . cord-010119-t1x9gknd 8699 1 Twenty twenty CD cord-010119-t1x9gknd 8699 2 patients patient NNS cord-010119-t1x9gknd 8699 3 ( ( -LRB- cord-010119-t1x9gknd 8699 4 8.5 8.5 CD cord-010119-t1x9gknd 8699 5 % % NN cord-010119-t1x9gknd 8699 6 ) ) -RRB- cord-010119-t1x9gknd 8699 7 were be VBD cord-010119-t1x9gknd 8699 8 transfused transfuse VBN cord-010119-t1x9gknd 8699 9 with with IN cord-010119-t1x9gknd 8699 10 incompatible incompatible JJ cord-010119-t1x9gknd 8699 11 group group NN cord-010119-t1x9gknd 8699 12 A a DT cord-010119-t1x9gknd 8699 13 plasma plasma NN cord-010119-t1x9gknd 8699 14 ( ( -LRB- cord-010119-t1x9gknd 8699 15 5 5 CD cord-010119-t1x9gknd 8699 16 group group NN cord-010119-t1x9gknd 8699 17 AB AB NNP cord-010119-t1x9gknd 8699 18 and and CC cord-010119-t1x9gknd 8699 19 15 15 CD cord-010119-t1x9gknd 8699 20 group group NN cord-010119-t1x9gknd 8699 21 B b NN cord-010119-t1x9gknd 8699 22 patients patient NNS cord-010119-t1x9gknd 8699 23 ) ) -RRB- cord-010119-t1x9gknd 8699 24 . . . cord-010119-t1x9gknd 8700 1 Five five CD cord-010119-t1x9gknd 8700 2 patients patient NNS cord-010119-t1x9gknd 8700 3 died die VBD cord-010119-t1x9gknd 8700 4 due due JJ cord-010119-t1x9gknd 8700 5 to to IN cord-010119-t1x9gknd 8700 6 severe severe JJ cord-010119-t1x9gknd 8700 7 injury injury NN cord-010119-t1x9gknd 8700 8 , , , cord-010119-t1x9gknd 8700 9 and and CC cord-010119-t1x9gknd 8700 10 follow follow VB cord-010119-t1x9gknd 8700 11 - - HYPH cord-010119-t1x9gknd 8700 12 up up NN cord-010119-t1x9gknd 8700 13 testing testing NN cord-010119-t1x9gknd 8700 14 of of IN cord-010119-t1x9gknd 8700 15 these these DT cord-010119-t1x9gknd 8700 16 patients patient NNS cord-010119-t1x9gknd 8700 17 could could MD cord-010119-t1x9gknd 8700 18 not not RB cord-010119-t1x9gknd 8700 19 be be VB cord-010119-t1x9gknd 8700 20 performed perform VBN cord-010119-t1x9gknd 8700 21 . . . cord-010119-t1x9gknd 8701 1 The the DT cord-010119-t1x9gknd 8701 2 remaining remain VBG cord-010119-t1x9gknd 8701 3 15 15 CD cord-010119-t1x9gknd 8701 4 patients patient NNS cord-010119-t1x9gknd 8701 5 had have VBD cord-010119-t1x9gknd 8701 6 negative negative JJ cord-010119-t1x9gknd 8701 7 DAT DAT NNP cord-010119-t1x9gknd 8701 8 , , , cord-010119-t1x9gknd 8701 9 indicating indicate VBG cord-010119-t1x9gknd 8701 10 the the DT cord-010119-t1x9gknd 8701 11 lack lack NN cord-010119-t1x9gknd 8701 12 of of IN cord-010119-t1x9gknd 8701 13 significant significant JJ cord-010119-t1x9gknd 8701 14 amount amount NN cord-010119-t1x9gknd 8701 15 of of IN cord-010119-t1x9gknd 8701 16 antibody antibody NN cord-010119-t1x9gknd 8701 17 coating coat VBG cord-010119-t1x9gknd 8701 18 their -PRON- PRP$ cord-010119-t1x9gknd 8701 19 red red JJ cord-010119-t1x9gknd 8701 20 cells cell NNS cord-010119-t1x9gknd 8701 21 , , , cord-010119-t1x9gknd 8701 22 which which WDT cord-010119-t1x9gknd 8701 23 could could MD cord-010119-t1x9gknd 8701 24 lead lead VB cord-010119-t1x9gknd 8701 25 to to IN cord-010119-t1x9gknd 8701 26 hemolysis hemolysis NN cord-010119-t1x9gknd 8701 27 . . . cord-010119-t1x9gknd 8702 1 None none NN cord-010119-t1x9gknd 8702 2 of of IN cord-010119-t1x9gknd 8702 3 these these DT cord-010119-t1x9gknd 8702 4 patients patient NNS cord-010119-t1x9gknd 8702 5 developed develop VBD cord-010119-t1x9gknd 8702 6 acute acute JJ cord-010119-t1x9gknd 8702 7 hemolytic hemolytic JJ cord-010119-t1x9gknd 8702 8 reaction reaction NN cord-010119-t1x9gknd 8702 9 , , , cord-010119-t1x9gknd 8702 10 or or CC cord-010119-t1x9gknd 8702 11 any any DT cord-010119-t1x9gknd 8702 12 other other JJ cord-010119-t1x9gknd 8702 13 adverse adverse JJ cord-010119-t1x9gknd 8702 14 effects effect NNS cord-010119-t1x9gknd 8702 15 of of IN cord-010119-t1x9gknd 8702 16 incompatible incompatible JJ cord-010119-t1x9gknd 8702 17 plasma plasma NN cord-010119-t1x9gknd 8702 18 transfusion transfusion NN cord-010119-t1x9gknd 8702 19 . . . cord-010119-t1x9gknd 8703 1 Conclusion conclusion NN cord-010119-t1x9gknd 8703 2 : : : cord-010119-t1x9gknd 8704 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8704 2 study study NN cord-010119-t1x9gknd 8704 3 adds add VBZ cord-010119-t1x9gknd 8704 4 more more JJR cord-010119-t1x9gknd 8704 5 evidence evidence NN cord-010119-t1x9gknd 8704 6 of of IN cord-010119-t1x9gknd 8704 7 the the DT cord-010119-t1x9gknd 8704 8 safety safety NN cord-010119-t1x9gknd 8704 9 of of IN cord-010119-t1x9gknd 8704 10 group group NN cord-010119-t1x9gknd 8704 11 A a DT cord-010119-t1x9gknd 8704 12 plasma plasma NN cord-010119-t1x9gknd 8704 13 transfusion transfusion NN cord-010119-t1x9gknd 8704 14 in in IN cord-010119-t1x9gknd 8704 15 trauma trauma NN cord-010119-t1x9gknd 8704 16 patients patient NNS cord-010119-t1x9gknd 8704 17 requiring require VBG cord-010119-t1x9gknd 8704 18 emergent emergent JJ cord-010119-t1x9gknd 8704 19 massive massive JJ cord-010119-t1x9gknd 8704 20 transfusion transfusion NN cord-010119-t1x9gknd 8704 21 before before IN cord-010119-t1x9gknd 8704 22 the the DT cord-010119-t1x9gknd 8704 23 patient patient JJ cord-010119-t1x9gknd 8704 24 blood blood NN cord-010119-t1x9gknd 8704 25 type type NN cord-010119-t1x9gknd 8704 26 is be VBZ cord-010119-t1x9gknd 8704 27 known know VBN cord-010119-t1x9gknd 8704 28 . . . cord-010119-t1x9gknd 8705 1 Based base VBN cord-010119-t1x9gknd 8705 2 on on IN cord-010119-t1x9gknd 8705 3 this this DT cord-010119-t1x9gknd 8705 4 and and CC cord-010119-t1x9gknd 8705 5 other other JJ cord-010119-t1x9gknd 8705 6 recently recently RB cord-010119-t1x9gknd 8705 7 published publish VBN cord-010119-t1x9gknd 8705 8 studies study NNS cord-010119-t1x9gknd 8705 9 , , , cord-010119-t1x9gknd 8705 10 starting start VBG cord-010119-t1x9gknd 8705 11 in in IN cord-010119-t1x9gknd 8705 12 April April NNP cord-010119-t1x9gknd 8705 13 2017 2017 CD cord-010119-t1x9gknd 8705 14 , , , cord-010119-t1x9gknd 8705 15 our -PRON- PRP$ cord-010119-t1x9gknd 8705 16 institute institute NN cord-010119-t1x9gknd 8705 17 will will MD cord-010119-t1x9gknd 8705 18 provide provide VB cord-010119-t1x9gknd 8705 19 only only RB cord-010119-t1x9gknd 8705 20 group group NN cord-010119-t1x9gknd 8705 21 A a DT cord-010119-t1x9gknd 8705 22 plasma plasma NN cord-010119-t1x9gknd 8705 23 for for IN cord-010119-t1x9gknd 8705 24 emergency emergency NN cord-010119-t1x9gknd 8705 25 release release NN cord-010119-t1x9gknd 8705 26 and and CC cord-010119-t1x9gknd 8705 27 MTP MTP NNP cord-010119-t1x9gknd 8705 28 cases case NNS cord-010119-t1x9gknd 8705 29 before before IN cord-010119-t1x9gknd 8705 30 the the DT cord-010119-t1x9gknd 8705 31 patient patient JJ cord-010119-t1x9gknd 8705 32 blood blood NN cord-010119-t1x9gknd 8705 33 type type NN cord-010119-t1x9gknd 8705 34 is be VBZ cord-010119-t1x9gknd 8705 35 known know VBN cord-010119-t1x9gknd 8705 36 . . . cord-010119-t1x9gknd 8706 1 Average average JJ cord-010119-t1x9gknd 8706 2 ( ( -LRB- cord-010119-t1x9gknd 8706 3 Background Background NNP cord-010119-t1x9gknd 8706 4 / / SYM cord-010119-t1x9gknd 8706 5 Case Case NNP cord-010119-t1x9gknd 8706 6 Studies Studies NNPS cord-010119-t1x9gknd 8707 1 : : : cord-010119-t1x9gknd 8707 2 In in IN cord-010119-t1x9gknd 8707 3 2013 2013 CD cord-010119-t1x9gknd 8707 4 , , , cord-010119-t1x9gknd 8707 5 Bonfils Bonfils NNP cord-010119-t1x9gknd 8707 6 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 8707 7 Reference Reference NNP cord-010119-t1x9gknd 8707 8 Lab Lab NNP cord-010119-t1x9gknd 8707 9 ( ( -LRB- cord-010119-t1x9gknd 8707 10 IRL IRL NNP cord-010119-t1x9gknd 8707 11 ) ) -RRB- cord-010119-t1x9gknd 8707 12 sent send VBD cord-010119-t1x9gknd 8707 13 out out RP cord-010119-t1x9gknd 8707 14 approximately approximately RB cord-010119-t1x9gknd 8707 15 245 245 CD cord-010119-t1x9gknd 8707 16 special special JJ cord-010119-t1x9gknd 8707 17 platelets platelet NNS cord-010119-t1x9gknd 8707 18 for for IN cord-010119-t1x9gknd 8707 19 patients patient NNS cord-010119-t1x9gknd 8707 20 with with IN cord-010119-t1x9gknd 8707 21 HLA HLA NNP cord-010119-t1x9gknd 8707 22 antibodies antibody NNS cord-010119-t1x9gknd 8707 23 . . . cord-010119-t1x9gknd 8708 1 By by IN cord-010119-t1x9gknd 8708 2 2016 2016 CD cord-010119-t1x9gknd 8708 3 , , , cord-010119-t1x9gknd 8708 4 HLA HLA NNP cord-010119-t1x9gknd 8708 5 platelet platelet NN cord-010119-t1x9gknd 8708 6 orders order NNS cord-010119-t1x9gknd 8708 7 increased increase VBD cord-010119-t1x9gknd 8708 8 dramatically dramatically RB cord-010119-t1x9gknd 8708 9 and and CC cord-010119-t1x9gknd 8708 10 the the DT cord-010119-t1x9gknd 8708 11 IRL IRL NNP cord-010119-t1x9gknd 8708 12 sent send VBD cord-010119-t1x9gknd 8708 13 out out RP cord-010119-t1x9gknd 8708 14 over over IN cord-010119-t1x9gknd 8708 15 650 650 CD cord-010119-t1x9gknd 8708 16 special special JJ cord-010119-t1x9gknd 8708 17 platelet platelet NN cord-010119-t1x9gknd 8708 18 products product NNS cord-010119-t1x9gknd 8708 19 . . . cord-010119-t1x9gknd 8709 1 The the DT cord-010119-t1x9gknd 8709 2 purpose purpose NN cord-010119-t1x9gknd 8709 3 of of IN cord-010119-t1x9gknd 8709 4 this this DT cord-010119-t1x9gknd 8709 5 abstract abstract NN cord-010119-t1x9gknd 8709 6 is be VBZ cord-010119-t1x9gknd 8709 7 to to TO cord-010119-t1x9gknd 8709 8 illuminate illuminate VB cord-010119-t1x9gknd 8709 9 the the DT cord-010119-t1x9gknd 8709 10 methods method NNS cord-010119-t1x9gknd 8709 11 used use VBN cord-010119-t1x9gknd 8709 12 to to TO cord-010119-t1x9gknd 8709 13 fulfill fulfill VB cord-010119-t1x9gknd 8709 14 increased increase VBN cord-010119-t1x9gknd 8709 15 client client NN cord-010119-t1x9gknd 8709 16 need need VBP cord-010119-t1x9gknd 8709 17 that that WDT cord-010119-t1x9gknd 8709 18 occurred occur VBD cord-010119-t1x9gknd 8709 19 in in IN cord-010119-t1x9gknd 8709 20 a a DT cord-010119-t1x9gknd 8709 21 short short JJ cord-010119-t1x9gknd 8709 22 period period NN cord-010119-t1x9gknd 8709 23 of of IN cord-010119-t1x9gknd 8709 24 time time NN cord-010119-t1x9gknd 8709 25 . . . cord-010119-t1x9gknd 8710 1 Study Study NNP cord-010119-t1x9gknd 8710 2 Design Design NNP cord-010119-t1x9gknd 8710 3 / / SYM cord-010119-t1x9gknd 8710 4 Methods method NNS cord-010119-t1x9gknd 8710 5 : : : cord-010119-t1x9gknd 8711 1 Bonfils Bonfils NNP cord-010119-t1x9gknd 8711 2 Blood Blood NNP cord-010119-t1x9gknd 8711 3 Center Center NNP cord-010119-t1x9gknd 8711 4 has have VBZ cord-010119-t1x9gknd 8711 5 over over IN cord-010119-t1x9gknd 8711 6 10,000 10,000 CD cord-010119-t1x9gknd 8711 7 donors donor NNS cord-010119-t1x9gknd 8711 8 in in IN cord-010119-t1x9gknd 8711 9 the the DT cord-010119-t1x9gknd 8711 10 database database NN cord-010119-t1x9gknd 8711 11 with with IN cord-010119-t1x9gknd 8711 12 historical historical JJ cord-010119-t1x9gknd 8711 13 HLA HLA NNP cord-010119-t1x9gknd 8711 14 typing typing NN cord-010119-t1x9gknd 8711 15 . . . cord-010119-t1x9gknd 8712 1 However however RB cord-010119-t1x9gknd 8712 2 , , , cord-010119-t1x9gknd 8712 3 only only RB cord-010119-t1x9gknd 8712 4 approximately approximately RB cord-010119-t1x9gknd 8712 5 3500 3500 CD cord-010119-t1x9gknd 8712 6 of of IN cord-010119-t1x9gknd 8712 7 those those DT cord-010119-t1x9gknd 8712 8 donors donor NNS cord-010119-t1x9gknd 8712 9 actively actively RB cord-010119-t1x9gknd 8712 10 donate donate VBP cord-010119-t1x9gknd 8712 11 . . . cord-010119-t1x9gknd 8713 1 In in IN cord-010119-t1x9gknd 8713 2 the the DT cord-010119-t1x9gknd 8713 3 Denver Denver NNP cord-010119-t1x9gknd 8713 4 area area NN cord-010119-t1x9gknd 8713 5 , , , cord-010119-t1x9gknd 8713 6 one one CD cord-010119-t1x9gknd 8713 7 of of IN cord-010119-t1x9gknd 8713 8 the the DT cord-010119-t1x9gknd 8713 9 most most RBS cord-010119-t1x9gknd 8713 10 common common JJ cord-010119-t1x9gknd 8713 11 HLA HLA NNP cord-010119-t1x9gknd 8713 12 types type NNS cord-010119-t1x9gknd 8713 13 is be VBZ cord-010119-t1x9gknd 8713 14 A1 A1 NNP cord-010119-t1x9gknd 8713 15 A2 A2 NNP cord-010119-t1x9gknd 8713 16 B7 b7 NN cord-010119-t1x9gknd 8713 17 B8 B8 NNP cord-010119-t1x9gknd 8713 18 . . . cord-010119-t1x9gknd 8714 1 Only only RB cord-010119-t1x9gknd 8714 2 81 81 CD cord-010119-t1x9gknd 8714 3 of of IN cord-010119-t1x9gknd 8714 4 the the DT cord-010119-t1x9gknd 8714 5 10,000 10,000 CD cord-010119-t1x9gknd 8714 6 donors donor NNS cord-010119-t1x9gknd 8714 7 have have VBP cord-010119-t1x9gknd 8714 8 this this DT cord-010119-t1x9gknd 8714 9 type type NN cord-010119-t1x9gknd 8714 10 ( ( -LRB- cord-010119-t1x9gknd 8714 11 0.81 0.81 CD cord-010119-t1x9gknd 8714 12 % % NN cord-010119-t1x9gknd 8714 13 ) ) -RRB- cord-010119-t1x9gknd 8714 14 . . . cord-010119-t1x9gknd 8715 1 Therefore therefore RB cord-010119-t1x9gknd 8715 2 , , , cord-010119-t1x9gknd 8715 3 to to TO cord-010119-t1x9gknd 8715 4 fill fill VB cord-010119-t1x9gknd 8715 5 an an DT cord-010119-t1x9gknd 8715 6 HLA HLA NNP cord-010119-t1x9gknd 8715 7 platelet platelet NN cord-010119-t1x9gknd 8715 8 order order NN cord-010119-t1x9gknd 8715 9 request request NN cord-010119-t1x9gknd 8715 10 for for IN cord-010119-t1x9gknd 8715 11 a a DT cord-010119-t1x9gknd 8715 12 common common JJ cord-010119-t1x9gknd 8715 13 HLA HLA NNP cord-010119-t1x9gknd 8715 14 type type NN cord-010119-t1x9gknd 8715 15 , , , cord-010119-t1x9gknd 8715 16 only only RB cord-010119-t1x9gknd 8715 17 28 28 CD cord-010119-t1x9gknd 8715 18 donors donor NNS cord-010119-t1x9gknd 8715 19 in in IN cord-010119-t1x9gknd 8715 20 the the DT cord-010119-t1x9gknd 8715 21 system system NN cord-010119-t1x9gknd 8715 22 would would MD cord-010119-t1x9gknd 8715 23 be be VB cord-010119-t1x9gknd 8715 24 a a DT cord-010119-t1x9gknd 8715 25 perfect perfect JJ cord-010119-t1x9gknd 8715 26 HLA HLA NNP cord-010119-t1x9gknd 8715 27 match match NN cord-010119-t1x9gknd 8715 28 . . . cord-010119-t1x9gknd 8716 1 With with IN cord-010119-t1x9gknd 8716 2 that that DT cord-010119-t1x9gknd 8716 3 low low JJ cord-010119-t1x9gknd 8716 4 number number NN cord-010119-t1x9gknd 8716 5 of of IN cord-010119-t1x9gknd 8716 6 donors donor NNS cord-010119-t1x9gknd 8716 7 , , , cord-010119-t1x9gknd 8716 8 it -PRON- PRP cord-010119-t1x9gknd 8716 9 is be VBZ cord-010119-t1x9gknd 8716 10 not not RB cord-010119-t1x9gknd 8716 11 likely likely JJ cord-010119-t1x9gknd 8716 12 that that IN cord-010119-t1x9gknd 8716 13 there there EX cord-010119-t1x9gknd 8716 14 would would MD cord-010119-t1x9gknd 8716 15 be be VB cord-010119-t1x9gknd 8716 16 a a DT cord-010119-t1x9gknd 8716 17 platelet platelet NN cord-010119-t1x9gknd 8716 18 on on IN cord-010119-t1x9gknd 8716 19 the the DT cord-010119-t1x9gknd 8716 20 shelf shelf NN cord-010119-t1x9gknd 8716 21 ready ready JJ cord-010119-t1x9gknd 8716 22 to to TO cord-010119-t1x9gknd 8716 23 fill fill VB cord-010119-t1x9gknd 8716 24 the the DT cord-010119-t1x9gknd 8716 25 order order NN cord-010119-t1x9gknd 8716 26 . . . cord-010119-t1x9gknd 8717 1 After after IN cord-010119-t1x9gknd 8717 2 a a DT cord-010119-t1x9gknd 8717 3 donor donor NN cord-010119-t1x9gknd 8717 4 is be VBZ cord-010119-t1x9gknd 8717 5 recruited recruit VBN cord-010119-t1x9gknd 8717 6 and and CC cord-010119-t1x9gknd 8717 7 donates donate VBZ cord-010119-t1x9gknd 8717 8 , , , cord-010119-t1x9gknd 8717 9 it -PRON- PRP cord-010119-t1x9gknd 8717 10 takes take VBZ cord-010119-t1x9gknd 8717 11 at at RB cord-010119-t1x9gknd 8717 12 least least RBS cord-010119-t1x9gknd 8717 13 two two CD cord-010119-t1x9gknd 8717 14 days day NNS cord-010119-t1x9gknd 8717 15 to to TO cord-010119-t1x9gknd 8717 16 fill fill VB cord-010119-t1x9gknd 8717 17 an an DT cord-010119-t1x9gknd 8717 18 order order NN cord-010119-t1x9gknd 8717 19 . . . cord-010119-t1x9gknd 8718 1 For for IN cord-010119-t1x9gknd 8718 2 a a DT cord-010119-t1x9gknd 8718 3 less less RBR cord-010119-t1x9gknd 8718 4 uncommon uncommon JJ cord-010119-t1x9gknd 8718 5 HLA HLA NNP cord-010119-t1x9gknd 8718 6 type type NN cord-010119-t1x9gknd 8718 7 like like IN cord-010119-t1x9gknd 8718 8 A9 A9 NNP cord-010119-t1x9gknd 8718 9 A11 A11 NNP cord-010119-t1x9gknd 8718 10 B17 B17 NNP cord-010119-t1x9gknd 8718 11 B35 B35 NNP cord-010119-t1x9gknd 8718 12 , , , cord-010119-t1x9gknd 8718 13 there there EX cord-010119-t1x9gknd 8718 14 is be VBZ cord-010119-t1x9gknd 8718 15 only only RB cord-010119-t1x9gknd 8718 16 1 1 CD cord-010119-t1x9gknd 8718 17 out out IN cord-010119-t1x9gknd 8718 18 of of IN cord-010119-t1x9gknd 8718 19 10,000 10,000 CD cord-010119-t1x9gknd 8718 20 donors donor NNS cord-010119-t1x9gknd 8718 21 ( ( -LRB- cord-010119-t1x9gknd 8718 22 0.01 0.01 CD cord-010119-t1x9gknd 8718 23 % % NN cord-010119-t1x9gknd 8718 24 ) ) -RRB- cord-010119-t1x9gknd 8718 25 that that WDT cord-010119-t1x9gknd 8718 26 match match VBP cord-010119-t1x9gknd 8718 27 perfectly perfectly RB cord-010119-t1x9gknd 8718 28 . . . cord-010119-t1x9gknd 8719 1 In in IN cord-010119-t1x9gknd 8719 2 those those DT cord-010119-t1x9gknd 8719 3 cases case NNS cord-010119-t1x9gknd 8719 4 , , , cord-010119-t1x9gknd 8719 5 there there EX cord-010119-t1x9gknd 8719 6 are be VBP cord-010119-t1x9gknd 8719 7 no no DT cord-010119-t1x9gknd 8719 8 donors donor NNS cord-010119-t1x9gknd 8719 9 to to TO cord-010119-t1x9gknd 8719 10 recruit recruit VB cord-010119-t1x9gknd 8719 11 to to TO cord-010119-t1x9gknd 8719 12 fill fill VB cord-010119-t1x9gknd 8719 13 such such PDT cord-010119-t1x9gknd 8719 14 an an DT cord-010119-t1x9gknd 8719 15 order order NN cord-010119-t1x9gknd 8719 16 . . . cord-010119-t1x9gknd 8720 1 In in IN cord-010119-t1x9gknd 8720 2 some some DT cord-010119-t1x9gknd 8720 3 complicated complicated JJ cord-010119-t1x9gknd 8720 4 cases case NNS cord-010119-t1x9gknd 8720 5 , , , cord-010119-t1x9gknd 8720 6 the the DT cord-010119-t1x9gknd 8720 7 IRL IRL NNP cord-010119-t1x9gknd 8720 8 was be VBD cord-010119-t1x9gknd 8720 9 provided provide VBN cord-010119-t1x9gknd 8720 10 with with IN cord-010119-t1x9gknd 8720 11 an an DT cord-010119-t1x9gknd 8720 12 HLA HLA NNP cord-010119-t1x9gknd 8720 13 antibody antibody NN cord-010119-t1x9gknd 8720 14 list list NN cord-010119-t1x9gknd 8720 15 or or CC cord-010119-t1x9gknd 8720 16 Panel Panel NNP cord-010119-t1x9gknd 8720 17 Reactive Reactive NNP cord-010119-t1x9gknd 8720 18 Antibody Antibody NNP cord-010119-t1x9gknd 8720 19 test test NN cord-010119-t1x9gknd 8720 20 ( ( -LRB- cord-010119-t1x9gknd 8720 21 PRA PRA NNP cord-010119-t1x9gknd 8720 22 ) ) -RRB- cord-010119-t1x9gknd 8720 23 . . . cord-010119-t1x9gknd 8721 1 In in IN cord-010119-t1x9gknd 8721 2 order order NN cord-010119-t1x9gknd 8721 3 to to TO cord-010119-t1x9gknd 8721 4 find find VB cord-010119-t1x9gknd 8721 5 product product NN cord-010119-t1x9gknd 8721 6 for for IN cord-010119-t1x9gknd 8721 7 these these DT cord-010119-t1x9gknd 8721 8 patients patient NNS cord-010119-t1x9gknd 8721 9 , , , cord-010119-t1x9gknd 8721 10 lists list NNS cord-010119-t1x9gknd 8721 11 of of IN cord-010119-t1x9gknd 8721 12 platelets platelet NNS cord-010119-t1x9gknd 8721 13 in in IN cord-010119-t1x9gknd 8721 14 inventory inventory NN cord-010119-t1x9gknd 8721 15 with with IN cord-010119-t1x9gknd 8721 16 corresponding correspond VBG cord-010119-t1x9gknd 8721 17 HLA HLA NNP cord-010119-t1x9gknd 8721 18 types type NNS cord-010119-t1x9gknd 8721 19 were be VBD cord-010119-t1x9gknd 8721 20 printed print VBN cord-010119-t1x9gknd 8721 21 . . . cord-010119-t1x9gknd 8722 1 If if IN cord-010119-t1x9gknd 8722 2 a a DT cord-010119-t1x9gknd 8722 3 patient patient NN cord-010119-t1x9gknd 8722 4 had have VBD cord-010119-t1x9gknd 8722 5 an an DT cord-010119-t1x9gknd 8722 6 antibody antibody NN cord-010119-t1x9gknd 8722 7 to to IN cord-010119-t1x9gknd 8722 8 A1 A1 NNP cord-010119-t1x9gknd 8722 9 for for IN cord-010119-t1x9gknd 8722 10 example example NN cord-010119-t1x9gknd 8722 11 , , , cord-010119-t1x9gknd 8722 12 all all DT cord-010119-t1x9gknd 8722 13 of of IN cord-010119-t1x9gknd 8722 14 the the DT cord-010119-t1x9gknd 8722 15 A1 A1 NNP cord-010119-t1x9gknd 8722 16 positive positive JJ cord-010119-t1x9gknd 8722 17 platelets platelet NNS cord-010119-t1x9gknd 8722 18 were be VBD cord-010119-t1x9gknd 8722 19 crossed cross VBN cord-010119-t1x9gknd 8722 20 off off IN cord-010119-t1x9gknd 8722 21 the the DT cord-010119-t1x9gknd 8722 22 list list NN cord-010119-t1x9gknd 8722 23 . . . cord-010119-t1x9gknd 8723 1 This this DT cord-010119-t1x9gknd 8723 2 cross cross JJ cord-010119-t1x9gknd 8723 3 - - HYPH cord-010119-t1x9gknd 8723 4 out out JJ cord-010119-t1x9gknd 8723 5 process process NN cord-010119-t1x9gknd 8723 6 would would MD cord-010119-t1x9gknd 8723 7 continue continue VB cord-010119-t1x9gknd 8723 8 manually manually RB cord-010119-t1x9gknd 8723 9 until until IN cord-010119-t1x9gknd 8723 10 the the DT cord-010119-t1x9gknd 8723 11 only only JJ cord-010119-t1x9gknd 8723 12 platelets platelet NNS cord-010119-t1x9gknd 8723 13 on on IN cord-010119-t1x9gknd 8723 14 the the DT cord-010119-t1x9gknd 8723 15 list list NN cord-010119-t1x9gknd 8723 16 were be VBD cord-010119-t1x9gknd 8723 17 the the DT cord-010119-t1x9gknd 8723 18 ones one NNS cord-010119-t1x9gknd 8723 19 positive positive JJ cord-010119-t1x9gknd 8723 20 for for IN cord-010119-t1x9gknd 8723 21 HLA HLA NNP cord-010119-t1x9gknd 8723 22 antigens antigen NNS cord-010119-t1x9gknd 8723 23 to to TO cord-010119-t1x9gknd 8723 24 which which WDT cord-010119-t1x9gknd 8723 25 the the DT cord-010119-t1x9gknd 8723 26 patient patient NN cord-010119-t1x9gknd 8723 27 did do VBD cord-010119-t1x9gknd 8723 28 not not RB cord-010119-t1x9gknd 8723 29 have have VB cord-010119-t1x9gknd 8723 30 antibodies antibody NNS cord-010119-t1x9gknd 8723 31 . . . cord-010119-t1x9gknd 8724 1 These these DT cord-010119-t1x9gknd 8724 2 platelets platelet NNS cord-010119-t1x9gknd 8724 3 are be VBP cord-010119-t1x9gknd 8724 4 PRA PRA NNP cord-010119-t1x9gknd 8724 5 matched match VBN cord-010119-t1x9gknd 8724 6 to to IN cord-010119-t1x9gknd 8724 7 the the DT cord-010119-t1x9gknd 8724 8 patient patient NN cord-010119-t1x9gknd 8724 9 . . . cord-010119-t1x9gknd 8725 1 In in IN cord-010119-t1x9gknd 8725 2 order order NN cord-010119-t1x9gknd 8725 3 to to TO cord-010119-t1x9gknd 8725 4 automate automate VB cord-010119-t1x9gknd 8725 5 this this DT cord-010119-t1x9gknd 8725 6 process process NN cord-010119-t1x9gknd 8725 7 a a DT cord-010119-t1x9gknd 8725 8 report report NN cord-010119-t1x9gknd 8725 9 linked link VBN cord-010119-t1x9gknd 8725 10 to to IN cord-010119-t1x9gknd 8725 11 the the DT cord-010119-t1x9gknd 8725 12 donor donor NN cord-010119-t1x9gknd 8725 13 database database NN cord-010119-t1x9gknd 8725 14 was be VBD cord-010119-t1x9gknd 8725 15 created create VBN cord-010119-t1x9gknd 8725 16 to to TO cord-010119-t1x9gknd 8725 17 find find VB cord-010119-t1x9gknd 8725 18 both both CC cord-010119-t1x9gknd 8725 19 PRA PRA NNP cord-010119-t1x9gknd 8725 20 platelets platelet NNS cord-010119-t1x9gknd 8725 21 in in IN cord-010119-t1x9gknd 8725 22 inventory inventory NN cord-010119-t1x9gknd 8725 23 and and CC cord-010119-t1x9gknd 8725 24 donors donor NNS cord-010119-t1x9gknd 8725 25 for for IN cord-010119-t1x9gknd 8725 26 recruitment recruitment NN cord-010119-t1x9gknd 8725 27 . . . cord-010119-t1x9gknd 8726 1 The the DT cord-010119-t1x9gknd 8726 2 blood blood NN cord-010119-t1x9gknd 8726 3 center center NN cord-010119-t1x9gknd 8726 4 medical medical JJ cord-010119-t1x9gknd 8726 5 director director NN cord-010119-t1x9gknd 8726 6 began begin VBD cord-010119-t1x9gknd 8726 7 suggesting suggest VBG cord-010119-t1x9gknd 8726 8 that that IN cord-010119-t1x9gknd 8726 9 hospital hospital NN cord-010119-t1x9gknd 8726 10 clients client NNS cord-010119-t1x9gknd 8726 11 order order VBP cord-010119-t1x9gknd 8726 12 a a DT cord-010119-t1x9gknd 8726 13 PRA PRA NNP cord-010119-t1x9gknd 8726 14 for for IN cord-010119-t1x9gknd 8726 15 each each DT cord-010119-t1x9gknd 8726 16 patient patient NN cord-010119-t1x9gknd 8726 17 with with IN cord-010119-t1x9gknd 8726 18 platelet platelet NN cord-010119-t1x9gknd 8726 19 refractoriness refractoriness NN cord-010119-t1x9gknd 8726 20 . . . cord-010119-t1x9gknd 8727 1 The the DT cord-010119-t1x9gknd 8727 2 PRA PRA NNP cord-010119-t1x9gknd 8727 3 test test NN cord-010119-t1x9gknd 8727 4 is be VBZ cord-010119-t1x9gknd 8727 5 fast fast JJ cord-010119-t1x9gknd 8727 6 and and CC cord-010119-t1x9gknd 8727 7 it -PRON- PRP cord-010119-t1x9gknd 8727 8 is be VBZ cord-010119-t1x9gknd 8727 9 a a DT cord-010119-t1x9gknd 8727 10 definitive definitive JJ cord-010119-t1x9gknd 8727 11 method method NN cord-010119-t1x9gknd 8727 12 to to TO cord-010119-t1x9gknd 8727 13 discern discern VB cord-010119-t1x9gknd 8727 14 HLA HLA NNP cord-010119-t1x9gknd 8727 15 antibody antibody NN cord-010119-t1x9gknd 8727 16 mediated mediate VBD cord-010119-t1x9gknd 8727 17 refractoriness refractoriness NN cord-010119-t1x9gknd 8727 18 from from IN cord-010119-t1x9gknd 8727 19 platelet platelet NN cord-010119-t1x9gknd 8727 20 refractoriness refractoriness NN cord-010119-t1x9gknd 8727 21 due due IN cord-010119-t1x9gknd 8727 22 to to IN cord-010119-t1x9gknd 8727 23 other other JJ cord-010119-t1x9gknd 8727 24 causes cause NNS cord-010119-t1x9gknd 8727 25 . . . cord-010119-t1x9gknd 8728 1 Results result NNS cord-010119-t1x9gknd 8728 2 / / SYM cord-010119-t1x9gknd 8728 3 Findings finding NNS cord-010119-t1x9gknd 8728 4 : : : cord-010119-t1x9gknd 8728 5 In in IN cord-010119-t1x9gknd 8728 6 all all DT cord-010119-t1x9gknd 8728 7 but but IN cord-010119-t1x9gknd 8728 8 the the DT cord-010119-t1x9gknd 8728 9 most most RBS cord-010119-t1x9gknd 8728 10 complicated complicated JJ cord-010119-t1x9gknd 8728 11 cases case NNS cord-010119-t1x9gknd 8728 12 with with IN cord-010119-t1x9gknd 8728 13 rare rare JJ cord-010119-t1x9gknd 8728 14 HLA HLA NNP cord-010119-t1x9gknd 8728 15 patient patient NN cord-010119-t1x9gknd 8728 16 phenotypes phenotype NNS cord-010119-t1x9gknd 8729 1 , , , cord-010119-t1x9gknd 8729 2 it -PRON- PRP cord-010119-t1x9gknd 8729 3 was be VBD cord-010119-t1x9gknd 8729 4 much much RB cord-010119-t1x9gknd 8729 5 easier easy JJR cord-010119-t1x9gknd 8729 6 to to TO cord-010119-t1x9gknd 8729 7 find find VB cord-010119-t1x9gknd 8729 8 a a DT cord-010119-t1x9gknd 8729 9 PRA PRA NNP cord-010119-t1x9gknd 8729 10 patient patient NN cord-010119-t1x9gknd 8729 11 matched match VBN cord-010119-t1x9gknd 8729 12 platelet platelet NN cord-010119-t1x9gknd 8729 13 on on IN cord-010119-t1x9gknd 8729 14 the the DT cord-010119-t1x9gknd 8729 15 shelf shelf NN cord-010119-t1x9gknd 8729 16 than than IN cord-010119-t1x9gknd 8729 17 an an DT cord-010119-t1x9gknd 8729 18 HLA HLA NNP cord-010119-t1x9gknd 8729 19 match match NN cord-010119-t1x9gknd 8729 20 donor donor NN cord-010119-t1x9gknd 8729 21 . . . cord-010119-t1x9gknd 8730 1 In in IN cord-010119-t1x9gknd 8730 2 2012 2012 CD cord-010119-t1x9gknd 8730 3 , , , cord-010119-t1x9gknd 8730 4 approximately approximately RB cord-010119-t1x9gknd 8730 5 27 27 CD cord-010119-t1x9gknd 8730 6 % % NN cord-010119-t1x9gknd 8730 7 of of IN cord-010119-t1x9gknd 8730 8 these these DT cord-010119-t1x9gknd 8730 9 special special JJ cord-010119-t1x9gknd 8730 10 order order NN cord-010119-t1x9gknd 8730 11 platelets platelet NNS cord-010119-t1x9gknd 8730 12 were be VBD cord-010119-t1x9gknd 8730 13 PRA PRA NNP cord-010119-t1x9gknd 8730 14 matched match VBN cord-010119-t1x9gknd 8730 15 and and CC cord-010119-t1x9gknd 8730 16 the the DT cord-010119-t1x9gknd 8730 17 remaining remain VBG cord-010119-t1x9gknd 8730 18 73 73 CD cord-010119-t1x9gknd 8730 19 % % NN cord-010119-t1x9gknd 8730 20 were be VBD cord-010119-t1x9gknd 8730 21 HLA HLA NNP cord-010119-t1x9gknd 8730 22 matched match VBN cord-010119-t1x9gknd 8730 23 by by IN cord-010119-t1x9gknd 8730 24 donor donor NN cord-010119-t1x9gknd 8730 25 recruitment recruitment NN cord-010119-t1x9gknd 8730 26 . . . cord-010119-t1x9gknd 8731 1 By by IN cord-010119-t1x9gknd 8731 2 2017 2017 CD cord-010119-t1x9gknd 8731 3 , , , cord-010119-t1x9gknd 8731 4 approximately approximately RB cord-010119-t1x9gknd 8731 5 59 59 CD cord-010119-t1x9gknd 8731 6 % % NN cord-010119-t1x9gknd 8731 7 of of IN cord-010119-t1x9gknd 8731 8 special special JJ cord-010119-t1x9gknd 8731 9 platelets platelet NNS cord-010119-t1x9gknd 8731 10 sent send VBN cord-010119-t1x9gknd 8731 11 are be VBP cord-010119-t1x9gknd 8731 12 PRA PRA NNP cord-010119-t1x9gknd 8731 13 matched match VBN cord-010119-t1x9gknd 8731 14 . . . cord-010119-t1x9gknd 8732 1 This this DT cord-010119-t1x9gknd 8732 2 change change NN cord-010119-t1x9gknd 8732 3 resulted result VBD cord-010119-t1x9gknd 8732 4 in in IN cord-010119-t1x9gknd 8732 5 a a DT cord-010119-t1x9gknd 8732 6 2.2 2.2 CD cord-010119-t1x9gknd 8732 7 fold fold JJ cord-010119-t1x9gknd 8732 8 increase increase NN cord-010119-t1x9gknd 8732 9 of of IN cord-010119-t1x9gknd 8732 10 finding find VBG cord-010119-t1x9gknd 8732 11 product product NN cord-010119-t1x9gknd 8732 12 in in IN cord-010119-t1x9gknd 8732 13 inventory inventory NN cord-010119-t1x9gknd 8732 14 to to TO cord-010119-t1x9gknd 8732 15 fill fill VB cord-010119-t1x9gknd 8732 16 orders order NNS cord-010119-t1x9gknd 8732 17 quickly quickly RB cord-010119-t1x9gknd 8732 18 . . . cord-010119-t1x9gknd 8733 1 Conclusion conclusion NN cord-010119-t1x9gknd 8733 2 : : : cord-010119-t1x9gknd 8733 3 Developing develop VBG cord-010119-t1x9gknd 8733 4 a a DT cord-010119-t1x9gknd 8733 5 system system NN cord-010119-t1x9gknd 8733 6 to to TO cord-010119-t1x9gknd 8733 7 provide provide VB cord-010119-t1x9gknd 8733 8 PRA PRA NNP cord-010119-t1x9gknd 8733 9 matched match VBN cord-010119-t1x9gknd 8733 10 platelets platelet NNS cord-010119-t1x9gknd 8733 11 is be VBZ cord-010119-t1x9gknd 8733 12 a a DT cord-010119-t1x9gknd 8733 13 faster fast JJR cord-010119-t1x9gknd 8733 14 alternative alternative NN cord-010119-t1x9gknd 8733 15 to to IN cord-010119-t1x9gknd 8733 16 finding find VBG cord-010119-t1x9gknd 8733 17 HLA HLA NNP cord-010119-t1x9gknd 8733 18 matched match VBN cord-010119-t1x9gknd 8733 19 platelets platelet NNS cord-010119-t1x9gknd 8733 20 thus thus RB cord-010119-t1x9gknd 8733 21 contributing contribute VBG cord-010119-t1x9gknd 8733 22 to to IN cord-010119-t1x9gknd 8733 23 better well JJR cord-010119-t1x9gknd 8733 24 patient patient JJ cord-010119-t1x9gknd 8733 25 care care NN cord-010119-t1x9gknd 8733 26 . . . cord-010119-t1x9gknd 8734 1 Background Background NNP cord-010119-t1x9gknd 8734 2 / / SYM cord-010119-t1x9gknd 8734 3 Case Case NNP cord-010119-t1x9gknd 8734 4 Studies Studies NNPS cord-010119-t1x9gknd 8734 5 : : : cord-010119-t1x9gknd 8735 1 In in IN cord-010119-t1x9gknd 8735 2 urgent urgent JJ cord-010119-t1x9gknd 8735 3 cases case NNS cord-010119-t1x9gknd 8735 4 where where WRB cord-010119-t1x9gknd 8735 5 large large JJ cord-010119-t1x9gknd 8735 6 amounts amount NNS cord-010119-t1x9gknd 8735 7 of of IN cord-010119-t1x9gknd 8735 8 blood blood NN cord-010119-t1x9gknd 8735 9 products product NNS cord-010119-t1x9gknd 8735 10 are be VBP cord-010119-t1x9gknd 8735 11 needed need VBN cord-010119-t1x9gknd 8735 12 quickly quickly RB cord-010119-t1x9gknd 8735 13 , , , cord-010119-t1x9gknd 8735 14 maintaining maintain VBG cord-010119-t1x9gknd 8735 15 a a DT cord-010119-t1x9gknd 8735 16 standard standard JJ cord-010119-t1x9gknd 8735 17 massive massive JJ cord-010119-t1x9gknd 8735 18 transfusion transfusion NN cord-010119-t1x9gknd 8735 19 protocol protocol NN cord-010119-t1x9gknd 8735 20 ( ( -LRB- cord-010119-t1x9gknd 8735 21 MTP MTP NNP cord-010119-t1x9gknd 8735 22 ) ) -RRB- cord-010119-t1x9gknd 8735 23 is be VBZ cord-010119-t1x9gknd 8735 24 critical critical JJ cord-010119-t1x9gknd 8735 25 to to IN cord-010119-t1x9gknd 8735 26 the the DT cord-010119-t1x9gknd 8735 27 timely timely JJ cord-010119-t1x9gknd 8735 28 delivery delivery NN cord-010119-t1x9gknd 8735 29 of of IN cord-010119-t1x9gknd 8735 30 these these DT cord-010119-t1x9gknd 8735 31 products product NNS cord-010119-t1x9gknd 8735 32 . . . cord-010119-t1x9gknd 8736 1 Each each DT cord-010119-t1x9gknd 8736 2 MTP MTP NNP cord-010119-t1x9gknd 8736 3 pack pack NN cord-010119-t1x9gknd 8736 4 at at IN cord-010119-t1x9gknd 8736 5 UCM UCM NNP cord-010119-t1x9gknd 8736 6 contains contain VBZ cord-010119-t1x9gknd 8736 7 6 6 CD cord-010119-t1x9gknd 8736 8 packed packed JJ cord-010119-t1x9gknd 8736 9 red red JJ cord-010119-t1x9gknd 8736 10 blood blood NN cord-010119-t1x9gknd 8736 11 cells cell NNS cord-010119-t1x9gknd 8736 12 ( ( -LRB- cord-010119-t1x9gknd 8736 13 pRBCs prbcs RB cord-010119-t1x9gknd 8736 14 ) ) -RRB- cord-010119-t1x9gknd 8736 15 , , , cord-010119-t1x9gknd 8736 16 4 4 CD cord-010119-t1x9gknd 8736 17 fresh fresh JJ cord-010119-t1x9gknd 8736 18 frozen frozen JJ cord-010119-t1x9gknd 8736 19 plasma plasma NN cord-010119-t1x9gknd 8736 20 ( ( -LRB- cord-010119-t1x9gknd 8736 21 FFP FFP NNP cord-010119-t1x9gknd 8736 22 ) ) -RRB- cord-010119-t1x9gknd 8736 23 units unit NNS cord-010119-t1x9gknd 8736 24 , , , cord-010119-t1x9gknd 8736 25 and and CC cord-010119-t1x9gknd 8736 26 1 1 CD cord-010119-t1x9gknd 8736 27 plateletpheresis plateletpheresis NN cord-010119-t1x9gknd 8736 28 pack pack NN cord-010119-t1x9gknd 8736 29 ; ; : cord-010119-t1x9gknd 8736 30 a a DT cord-010119-t1x9gknd 8736 31 unit unit NN cord-010119-t1x9gknd 8736 32 of of IN cord-010119-t1x9gknd 8736 33 prepooled prepooled NNP cord-010119-t1x9gknd 8736 34 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8736 35 is be VBZ cord-010119-t1x9gknd 8736 36 also also RB cord-010119-t1x9gknd 8736 37 given give VBN cord-010119-t1x9gknd 8736 38 if if IN cord-010119-t1x9gknd 8736 39 the the DT cord-010119-t1x9gknd 8736 40 patient patient NN cord-010119-t1x9gknd 8736 41 is be VBZ cord-010119-t1x9gknd 8736 42 in in IN cord-010119-t1x9gknd 8736 43 Labor Labor NNP cord-010119-t1x9gknd 8736 44 and and CC cord-010119-t1x9gknd 8736 45 Delivery Delivery NNP cord-010119-t1x9gknd 8736 46 ( ( -LRB- cord-010119-t1x9gknd 8736 47 L&D L&D NNP cord-010119-t1x9gknd 8736 48 ) ) -RRB- cord-010119-t1x9gknd 8736 49 or or CC cord-010119-t1x9gknd 8736 50 if if IN cord-010119-t1x9gknd 8736 51 one one CD cord-010119-t1x9gknd 8736 52 is be VBZ cord-010119-t1x9gknd 8736 53 requested request VBN cord-010119-t1x9gknd 8736 54 . . . cord-010119-t1x9gknd 8737 1 At at IN cord-010119-t1x9gknd 8737 2 UCM UCM NNP cord-010119-t1x9gknd 8737 3 , , , cord-010119-t1x9gknd 8737 4 blood blood NN cord-010119-t1x9gknd 8737 5 products product NNS cord-010119-t1x9gknd 8737 6 are be VBP cord-010119-t1x9gknd 8737 7 generally generally RB cord-010119-t1x9gknd 8737 8 transported transport VBN cord-010119-t1x9gknd 8737 9 through through IN cord-010119-t1x9gknd 8737 10 the the DT cord-010119-t1x9gknd 8737 11 pneumatic pneumatic JJ cord-010119-t1x9gknd 8737 12 tube tube NN cord-010119-t1x9gknd 8737 13 system system NN cord-010119-t1x9gknd 8737 14 ( ( -LRB- cord-010119-t1x9gknd 8737 15 PTS PTS NNP cord-010119-t1x9gknd 8737 16 ) ) -RRB- cord-010119-t1x9gknd 8737 17 . . . cord-010119-t1x9gknd 8738 1 We -PRON- PRP cord-010119-t1x9gknd 8738 2 undertook undertake VBD cord-010119-t1x9gknd 8738 3 a a DT cord-010119-t1x9gknd 8738 4 review review NN cord-010119-t1x9gknd 8738 5 of of IN cord-010119-t1x9gknd 8738 6 our -PRON- PRP$ cord-010119-t1x9gknd 8738 7 MTP MTP NNP cord-010119-t1x9gknd 8738 8 issuing issue VBG cord-010119-t1x9gknd 8738 9 practices practice NNS cord-010119-t1x9gknd 8738 10 and and CC cord-010119-t1x9gknd 8738 11 efficiency efficiency NN cord-010119-t1x9gknd 8738 12 patterns pattern NNS cord-010119-t1x9gknd 8738 13 over over IN cord-010119-t1x9gknd 8738 14 the the DT cord-010119-t1x9gknd 8738 15 last last JJ cord-010119-t1x9gknd 8738 16 three three CD cord-010119-t1x9gknd 8738 17 and and CC cord-010119-t1x9gknd 8738 18 half half NN cord-010119-t1x9gknd 8738 19 years year NNS cord-010119-t1x9gknd 8738 20 . . . cord-010119-t1x9gknd 8739 1 Study Study NNP cord-010119-t1x9gknd 8739 2 Design Design NNP cord-010119-t1x9gknd 8739 3 / / SYM cord-010119-t1x9gknd 8739 4 Method method NN cord-010119-t1x9gknd 8739 5 : : : cord-010119-t1x9gknd 8740 1 The the DT cord-010119-t1x9gknd 8740 2 electronic electronic JJ cord-010119-t1x9gknd 8740 3 archives archive NNS cord-010119-t1x9gknd 8740 4 of of IN cord-010119-t1x9gknd 8740 5 the the DT cord-010119-t1x9gknd 8740 6 Blood Blood NNP cord-010119-t1x9gknd 8740 7 Bank Bank NNP cord-010119-t1x9gknd 8740 8 laboratory laboratory NN cord-010119-t1x9gknd 8740 9 information information NN cord-010119-t1x9gknd 8740 10 system system NN cord-010119-t1x9gknd 8740 11 and and CC cord-010119-t1x9gknd 8740 12 electronic electronic JJ cord-010119-t1x9gknd 8740 13 medical medical JJ cord-010119-t1x9gknd 8740 14 record record NN cord-010119-t1x9gknd 8740 15 at at IN cord-010119-t1x9gknd 8740 16 our -PRON- PRP$ cord-010119-t1x9gknd 8740 17 institution institution NN cord-010119-t1x9gknd 8740 18 were be VBD cord-010119-t1x9gknd 8740 19 queried query VBN cord-010119-t1x9gknd 8740 20 for for IN cord-010119-t1x9gknd 8740 21 patients patient NNS cord-010119-t1x9gknd 8740 22 who who WP cord-010119-t1x9gknd 8740 23 had have VBD cord-010119-t1x9gknd 8740 24 MTP MTP NNP cord-010119-t1x9gknd 8740 25 activations activation NNS cord-010119-t1x9gknd 8740 26 . . . cord-010119-t1x9gknd 8741 1 The the DT cord-010119-t1x9gknd 8741 2 archives archive NNS cord-010119-t1x9gknd 8741 3 were be VBD cord-010119-t1x9gknd 8741 4 correlated correlate VBN cord-010119-t1x9gknd 8741 5 to to IN cord-010119-t1x9gknd 8741 6 paper paper NN cord-010119-t1x9gknd 8741 7 copies copy NNS cord-010119-t1x9gknd 8741 8 of of IN cord-010119-t1x9gknd 8741 9 these these DT cord-010119-t1x9gknd 8741 10 activations activation NNS cord-010119-t1x9gknd 8741 11 to to TO cord-010119-t1x9gknd 8741 12 collect collect VB cord-010119-t1x9gknd 8741 13 data datum NNS cord-010119-t1x9gknd 8741 14 pertaining pertain VBG cord-010119-t1x9gknd 8741 15 to to IN cord-010119-t1x9gknd 8741 16 the the DT cord-010119-t1x9gknd 8741 17 relevant relevant JJ cord-010119-t1x9gknd 8741 18 information information NN cord-010119-t1x9gknd 8741 19 such such JJ cord-010119-t1x9gknd 8741 20 as as IN cord-010119-t1x9gknd 8741 21 where where WRB cord-010119-t1x9gknd 8741 22 the the DT cord-010119-t1x9gknd 8741 23 order order NN cord-010119-t1x9gknd 8741 24 originated originate VBD cord-010119-t1x9gknd 8741 25 from from IN cord-010119-t1x9gknd 8741 26 , , , cord-010119-t1x9gknd 8741 27 how how WRB cord-010119-t1x9gknd 8741 28 quickly quickly RB cord-010119-t1x9gknd 8741 29 the the DT cord-010119-t1x9gknd 8741 30 first first JJ cord-010119-t1x9gknd 8741 31 product product NN cord-010119-t1x9gknd 8741 32 was be VBD cord-010119-t1x9gknd 8741 33 sent send VBN cord-010119-t1x9gknd 8741 34 out out RP cord-010119-t1x9gknd 8741 35 , , , cord-010119-t1x9gknd 8741 36 how how WRB cord-010119-t1x9gknd 8741 37 many many JJ cord-010119-t1x9gknd 8741 38 products product NNS cord-010119-t1x9gknd 8741 39 were be VBD cord-010119-t1x9gknd 8741 40 transfused transfuse VBN cord-010119-t1x9gknd 8741 41 , , , cord-010119-t1x9gknd 8741 42 and and CC cord-010119-t1x9gknd 8741 43 so so RB cord-010119-t1x9gknd 8741 44 on on RB cord-010119-t1x9gknd 8741 45 . . . cord-010119-t1x9gknd 8742 1 Results/ Results/ . cord-010119-t1x9gknd 8743 1 Finding finding NN cord-010119-t1x9gknd 8743 2 : : : cord-010119-t1x9gknd 8744 1 Between between IN cord-010119-t1x9gknd 8744 2 August August NNP cord-010119-t1x9gknd 8744 3 2013 2013 CD cord-010119-t1x9gknd 8744 4 to to IN cord-010119-t1x9gknd 8744 5 March March NNP cord-010119-t1x9gknd 8744 6 2017 2017 CD cord-010119-t1x9gknd 8744 7 MTPs mtp NNS cord-010119-t1x9gknd 8744 8 were be VBD cord-010119-t1x9gknd 8744 9 activated activate VBN cord-010119-t1x9gknd 8744 10 at at IN cord-010119-t1x9gknd 8744 11 UCM UCM NNP cord-010119-t1x9gknd 8744 12 , , , cord-010119-t1x9gknd 8744 13 of of IN cord-010119-t1x9gknd 8744 14 which which WDT cord-010119-t1x9gknd 8744 15 251 251 CD cord-010119-t1x9gknd 8744 16 orders order NNS cord-010119-t1x9gknd 8744 17 could could MD cord-010119-t1x9gknd 8744 18 be be VB cord-010119-t1x9gknd 8744 19 traced trace VBN cord-010119-t1x9gknd 8744 20 to to IN cord-010119-t1x9gknd 8744 21 the the DT cord-010119-t1x9gknd 8744 22 origin origin NN cord-010119-t1x9gknd 8744 23 : : : cord-010119-t1x9gknd 8744 24 118 118 CD cord-010119-t1x9gknd 8744 25 on on IN cord-010119-t1x9gknd 8744 26 inpatient inpatient JJ cord-010119-t1x9gknd 8744 27 floor floor NN cord-010119-t1x9gknd 8744 28 ( ( -LRB- cord-010119-t1x9gknd 8744 29 including include VBG cord-010119-t1x9gknd 8744 30 ICUs ICUs NNP cord-010119-t1x9gknd 8744 31 ) ) -RRB- cord-010119-t1x9gknd 8744 32 , , , cord-010119-t1x9gknd 8744 33 58 58 CD cord-010119-t1x9gknd 8744 34 in in IN cord-010119-t1x9gknd 8744 35 the the DT cord-010119-t1x9gknd 8744 36 operating operate VBG cord-010119-t1x9gknd 8744 37 rooms room NNS cord-010119-t1x9gknd 8744 38 , , , cord-010119-t1x9gknd 8744 39 46 46 CD cord-010119-t1x9gknd 8744 40 in in IN cord-010119-t1x9gknd 8744 41 the the DT cord-010119-t1x9gknd 8744 42 Emergency Emergency NNP cord-010119-t1x9gknd 8744 43 Department Department NNP cord-010119-t1x9gknd 8744 44 , , , cord-010119-t1x9gknd 8744 45 25 25 CD cord-010119-t1x9gknd 8744 46 in in IN cord-010119-t1x9gknd 8744 47 Labor Labor NNP cord-010119-t1x9gknd 8744 48 and and CC cord-010119-t1x9gknd 8744 49 Delivery Delivery NNP cord-010119-t1x9gknd 8744 50 , , , cord-010119-t1x9gknd 8744 51 and and CC cord-010119-t1x9gknd 8744 52 4 4 CD cord-010119-t1x9gknd 8744 53 in in IN cord-010119-t1x9gknd 8744 54 other other JJ cord-010119-t1x9gknd 8744 55 procedure procedure NN cord-010119-t1x9gknd 8744 56 rooms room NNS cord-010119-t1x9gknd 8744 57 . . . cord-010119-t1x9gknd 8745 1 Of of IN cord-010119-t1x9gknd 8745 2 the the DT cord-010119-t1x9gknd 8745 3 2207 2207 CD cord-010119-t1x9gknd 8745 4 pRBCs pRBCs NNPS cord-010119-t1x9gknd 8745 5 that that WDT cord-010119-t1x9gknd 8745 6 were be VBD cord-010119-t1x9gknd 8745 7 issued issue VBN cord-010119-t1x9gknd 8745 8 , , , cord-010119-t1x9gknd 8745 9 1406 1406 CD cord-010119-t1x9gknd 8745 10 were be VBD cord-010119-t1x9gknd 8745 11 transfused transfuse VBN cord-010119-t1x9gknd 8745 12 ( ( -LRB- cord-010119-t1x9gknd 8745 13 64 64 CD cord-010119-t1x9gknd 8745 14 % % NN cord-010119-t1x9gknd 8745 15 utilized utilize VBN cord-010119-t1x9gknd 8745 16 ) ) -RRB- cord-010119-t1x9gknd 8745 17 ; ; : cord-010119-t1x9gknd 8745 18 of of IN cord-010119-t1x9gknd 8745 19 the the DT cord-010119-t1x9gknd 8745 20 1446 1446 CD cord-010119-t1x9gknd 8745 21 units unit NNS cord-010119-t1x9gknd 8745 22 of of IN cord-010119-t1x9gknd 8745 23 FFP FFP NNP cord-010119-t1x9gknd 8745 24 that that WDT cord-010119-t1x9gknd 8745 25 were be VBD cord-010119-t1x9gknd 8745 26 issued issue VBN cord-010119-t1x9gknd 8745 27 , , , cord-010119-t1x9gknd 8745 28 901 901 CD cord-010119-t1x9gknd 8745 29 were be VBD cord-010119-t1x9gknd 8745 30 transfused transfuse VBN cord-010119-t1x9gknd 8745 31 ( ( -LRB- cord-010119-t1x9gknd 8745 32 62 62 CD cord-010119-t1x9gknd 8745 33 % % NN cord-010119-t1x9gknd 8745 34 utilized utilize VBN cord-010119-t1x9gknd 8745 35 ) ) -RRB- cord-010119-t1x9gknd 8745 36 ; ; : cord-010119-t1x9gknd 8745 37 of of IN cord-010119-t1x9gknd 8745 38 the the DT cord-010119-t1x9gknd 8745 39 359 359 CD cord-010119-t1x9gknd 8745 40 platelet platelet NN cord-010119-t1x9gknd 8745 41 packs pack NNS cord-010119-t1x9gknd 8745 42 that that WDT cord-010119-t1x9gknd 8745 43 were be VBD cord-010119-t1x9gknd 8745 44 issued issue VBN cord-010119-t1x9gknd 8745 45 , , , cord-010119-t1x9gknd 8745 46 246 246 CD cord-010119-t1x9gknd 8745 47 were be VBD cord-010119-t1x9gknd 8745 48 transfused transfuse VBN cord-010119-t1x9gknd 8745 49 ( ( -LRB- cord-010119-t1x9gknd 8745 50 69 69 CD cord-010119-t1x9gknd 8745 51 % % NN cord-010119-t1x9gknd 8745 52 utilized utilize VBN cord-010119-t1x9gknd 8745 53 ) ) -RRB- cord-010119-t1x9gknd 8745 54 ; ; : cord-010119-t1x9gknd 8745 55 of of IN cord-010119-t1x9gknd 8745 56 the the DT cord-010119-t1x9gknd 8745 57 64 64 CD cord-010119-t1x9gknd 8745 58 units unit NNS cord-010119-t1x9gknd 8745 59 of of IN cord-010119-t1x9gknd 8745 60 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8745 61 that that WDT cord-010119-t1x9gknd 8745 62 were be VBD cord-010119-t1x9gknd 8745 63 issued issue VBN cord-010119-t1x9gknd 8745 64 , , , cord-010119-t1x9gknd 8745 65 49 49 CD cord-010119-t1x9gknd 8745 66 were be VBD cord-010119-t1x9gknd 8745 67 transfused transfuse VBN cord-010119-t1x9gknd 8745 68 ( ( -LRB- cord-010119-t1x9gknd 8745 69 77 77 CD cord-010119-t1x9gknd 8745 70 % % NN cord-010119-t1x9gknd 8745 71 utilized utilize VBN cord-010119-t1x9gknd 8745 72 ) ) -RRB- cord-010119-t1x9gknd 8745 73 . . . cord-010119-t1x9gknd 8746 1 Since since IN cord-010119-t1x9gknd 8746 2 March March NNP cord-010119-t1x9gknd 8746 3 2016 2016 CD cord-010119-t1x9gknd 8746 4 , , , cord-010119-t1x9gknd 8746 5 the the DT cord-010119-t1x9gknd 8746 6 time time NN cord-010119-t1x9gknd 8746 7 of of IN cord-010119-t1x9gknd 8746 8 first first JJ cord-010119-t1x9gknd 8746 9 product product NN cord-010119-t1x9gknd 8746 10 issue issue NN cord-010119-t1x9gknd 8746 11 after after IN cord-010119-t1x9gknd 8746 12 the the DT cord-010119-t1x9gknd 8746 13 initiation initiation NN cord-010119-t1x9gknd 8746 14 of of IN cord-010119-t1x9gknd 8746 15 an an DT cord-010119-t1x9gknd 8746 16 MTP MTP NNP cord-010119-t1x9gknd 8746 17 has have VBZ cord-010119-t1x9gknd 8746 18 also also RB cord-010119-t1x9gknd 8746 19 been be VBN cord-010119-t1x9gknd 8746 20 tracked track VBN cord-010119-t1x9gknd 8746 21 . . . cord-010119-t1x9gknd 8747 1 Of of IN cord-010119-t1x9gknd 8747 2 the the DT cord-010119-t1x9gknd 8747 3 84 84 CD cord-010119-t1x9gknd 8747 4 events event NNS cord-010119-t1x9gknd 8747 5 that that WDT cord-010119-t1x9gknd 8747 6 fall fall VBP cord-010119-t1x9gknd 8747 7 within within IN cord-010119-t1x9gknd 8747 8 this this DT cord-010119-t1x9gknd 8747 9 time time NN cord-010119-t1x9gknd 8747 10 period period NN cord-010119-t1x9gknd 8747 11 , , , cord-010119-t1x9gknd 8747 12 39 39 CD cord-010119-t1x9gknd 8747 13 ( ( -LRB- cord-010119-t1x9gknd 8747 14 46 46 CD cord-010119-t1x9gknd 8747 15 % % NN cord-010119-t1x9gknd 8747 16 ) ) -RRB- cord-010119-t1x9gknd 8747 17 , , , cord-010119-t1x9gknd 8747 18 had have VBD cord-010119-t1x9gknd 8747 19 the the DT cord-010119-t1x9gknd 8747 20 first first JJ cord-010119-t1x9gknd 8747 21 product product NN cord-010119-t1x9gknd 8747 22 issued issue VBN cord-010119-t1x9gknd 8747 23 in in IN cord-010119-t1x9gknd 8747 24 5 5 CD cord-010119-t1x9gknd 8747 25 minutes minute NNS cord-010119-t1x9gknd 8747 26 or or CC cord-010119-t1x9gknd 8747 27 less less JJR cord-010119-t1x9gknd 8747 28 . . . cord-010119-t1x9gknd 8748 1 Another another DT cord-010119-t1x9gknd 8748 2 31 31 CD cord-010119-t1x9gknd 8748 3 ( ( -LRB- cord-010119-t1x9gknd 8748 4 37 37 CD cord-010119-t1x9gknd 8748 5 % % NN cord-010119-t1x9gknd 8748 6 ) ) -RRB- cord-010119-t1x9gknd 8748 7 were be VBD cord-010119-t1x9gknd 8748 8 issued issue VBN cord-010119-t1x9gknd 8748 9 between between IN cord-010119-t1x9gknd 8748 10 5 5 CD cord-010119-t1x9gknd 8748 11 - - SYM cord-010119-t1x9gknd 8748 12 10 10 CD cord-010119-t1x9gknd 8748 13 minutes minute NNS cord-010119-t1x9gknd 8748 14 , , , cord-010119-t1x9gknd 8748 15 resulting result VBG cord-010119-t1x9gknd 8748 16 in in IN cord-010119-t1x9gknd 8748 17 over over IN cord-010119-t1x9gknd 8748 18 80 80 CD cord-010119-t1x9gknd 8748 19 % % NN cord-010119-t1x9gknd 8748 20 of of IN cord-010119-t1x9gknd 8748 21 patients patient NNS cord-010119-t1x9gknd 8748 22 being be VBG cord-010119-t1x9gknd 8748 23 issued issue VBN cord-010119-t1x9gknd 8748 24 their -PRON- PRP$ cord-010119-t1x9gknd 8748 25 first first JJ cord-010119-t1x9gknd 8748 26 blood blood NN cord-010119-t1x9gknd 8748 27 product product NN cord-010119-t1x9gknd 8748 28 within within IN cord-010119-t1x9gknd 8748 29 the the DT cord-010119-t1x9gknd 8748 30 first first JJ cord-010119-t1x9gknd 8748 31 10 10 CD cord-010119-t1x9gknd 8748 32 minutes minute NNS cord-010119-t1x9gknd 8748 33 . . . cord-010119-t1x9gknd 8749 1 Only only RB cord-010119-t1x9gknd 8749 2 15 15 CD cord-010119-t1x9gknd 8749 3 of of IN cord-010119-t1x9gknd 8749 4 84 84 CD cord-010119-t1x9gknd 8749 5 ( ( -LRB- cord-010119-t1x9gknd 8749 6 17 17 CD cord-010119-t1x9gknd 8749 7 % % NN cord-010119-t1x9gknd 8749 8 ) ) -RRB- cord-010119-t1x9gknd 8749 9 events event NNS cord-010119-t1x9gknd 8749 10 had have VBD cord-010119-t1x9gknd 8749 11 an an DT cord-010119-t1x9gknd 8749 12 initial initial JJ cord-010119-t1x9gknd 8749 13 time time NN cord-010119-t1x9gknd 8749 14 greater great JJR cord-010119-t1x9gknd 8749 15 than than IN cord-010119-t1x9gknd 8749 16 10 10 CD cord-010119-t1x9gknd 8749 17 minutes minute NNS cord-010119-t1x9gknd 8749 18 and and CC cord-010119-t1x9gknd 8749 19 none none NN cord-010119-t1x9gknd 8749 20 were be VBD cord-010119-t1x9gknd 8749 21 greater great JJR cord-010119-t1x9gknd 8749 22 than than IN cord-010119-t1x9gknd 8749 23 21 21 CD cord-010119-t1x9gknd 8749 24 minutes minute NNS cord-010119-t1x9gknd 8749 25 . . . cord-010119-t1x9gknd 8750 1 Conclusion conclusion NN cord-010119-t1x9gknd 8750 2 : : : cord-010119-t1x9gknd 8751 1 The the DT cord-010119-t1x9gknd 8751 2 majority majority NN cord-010119-t1x9gknd 8751 3 of of IN cord-010119-t1x9gknd 8751 4 our -PRON- PRP$ cord-010119-t1x9gknd 8751 5 activations activation NNS cord-010119-t1x9gknd 8751 6 currently currently RB cord-010119-t1x9gknd 8751 7 come come VBP cord-010119-t1x9gknd 8751 8 from from IN cord-010119-t1x9gknd 8751 9 inpatient inpatient JJ cord-010119-t1x9gknd 8751 10 floors floor NNS cord-010119-t1x9gknd 8751 11 ( ( -LRB- cord-010119-t1x9gknd 8751 12 primarily primarily RB cord-010119-t1x9gknd 8751 13 ICUs ICUs NNP cord-010119-t1x9gknd 8751 14 ) ) -RRB- cord-010119-t1x9gknd 8751 15 . . . cord-010119-t1x9gknd 8752 1 As as IN cord-010119-t1x9gknd 8752 2 our -PRON- PRP$ cord-010119-t1x9gknd 8752 3 institution institution NN cord-010119-t1x9gknd 8752 4 anticipates anticipate VBZ cord-010119-t1x9gknd 8752 5 the the DT cord-010119-t1x9gknd 8752 6 introduction introduction NN cord-010119-t1x9gknd 8752 7 of of IN cord-010119-t1x9gknd 8752 8 an an DT cord-010119-t1x9gknd 8752 9 adult adult NN cord-010119-t1x9gknd 8752 10 level level NN cord-010119-t1x9gknd 8752 11 1 1 CD cord-010119-t1x9gknd 8752 12 trauma trauma NN cord-010119-t1x9gknd 8752 13 center center NN cord-010119-t1x9gknd 8752 14 , , , cord-010119-t1x9gknd 8752 15 we -PRON- PRP cord-010119-t1x9gknd 8752 16 anticipate anticipate VBP cord-010119-t1x9gknd 8752 17 this this DT cord-010119-t1x9gknd 8752 18 balance balance NN cord-010119-t1x9gknd 8752 19 will will MD cord-010119-t1x9gknd 8752 20 shift shift VB cord-010119-t1x9gknd 8752 21 . . . cord-010119-t1x9gknd 8753 1 In in IN cord-010119-t1x9gknd 8753 2 addition addition NN cord-010119-t1x9gknd 8753 3 , , , cord-010119-t1x9gknd 8753 4 the the DT cord-010119-t1x9gknd 8753 5 data data NN cord-010119-t1x9gknd 8753 6 shows show VBZ cord-010119-t1x9gknd 8753 7 that that DT cord-010119-t1x9gknd 8753 8 ( ( -LRB- cord-010119-t1x9gknd 8753 9 with with IN cord-010119-t1x9gknd 8753 10 the the DT cord-010119-t1x9gknd 8753 11 exception exception NN cord-010119-t1x9gknd 8753 12 of of IN cord-010119-t1x9gknd 8753 13 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8753 14 ) ) -RRB- cord-010119-t1x9gknd 8753 15 the the DT cord-010119-t1x9gknd 8753 16 utilization utilization NN cord-010119-t1x9gknd 8753 17 rate rate NN cord-010119-t1x9gknd 8753 18 is be VBZ cord-010119-t1x9gknd 8753 19 nearly nearly RB cord-010119-t1x9gknd 8753 20 identical identical JJ cord-010119-t1x9gknd 8753 21 among among IN cord-010119-t1x9gknd 8753 22 the the DT cord-010119-t1x9gknd 8753 23 blood blood NN cord-010119-t1x9gknd 8753 24 products product NNS cord-010119-t1x9gknd 8753 25 sent send VBN cord-010119-t1x9gknd 8753 26 during during IN cord-010119-t1x9gknd 8753 27 MTP MTP NNP cord-010119-t1x9gknd 8753 28 activations activation NNS cord-010119-t1x9gknd 8753 29 ( ( -LRB- cord-010119-t1x9gknd 8753 30 $ $ $ cord-010119-t1x9gknd 8753 31 60 60 CD cord-010119-t1x9gknd 8753 32 - - SYM cord-010119-t1x9gknd 8753 33 70 70 CD cord-010119-t1x9gknd 8753 34 % % NN cord-010119-t1x9gknd 8753 35 ) ) -RRB- cord-010119-t1x9gknd 8753 36 . . . cord-010119-t1x9gknd 8754 1 Again again RB cord-010119-t1x9gknd 8754 2 , , , cord-010119-t1x9gknd 8754 3 we -PRON- PRP cord-010119-t1x9gknd 8754 4 anticipate anticipate VBP cord-010119-t1x9gknd 8754 5 utilization utilization NN cord-010119-t1x9gknd 8754 6 rate rate NN cord-010119-t1x9gknd 8754 7 of of IN cord-010119-t1x9gknd 8754 8 issued issue VBN cord-010119-t1x9gknd 8754 9 MTP MTP NNP cord-010119-t1x9gknd 8754 10 products product NNS cord-010119-t1x9gknd 8754 11 to to TO cord-010119-t1x9gknd 8754 12 increase increase VB cord-010119-t1x9gknd 8754 13 with with IN cord-010119-t1x9gknd 8754 14 the the DT cord-010119-t1x9gknd 8754 15 introduction introduction NN cord-010119-t1x9gknd 8754 16 of of IN cord-010119-t1x9gknd 8754 17 a a DT cord-010119-t1x9gknd 8754 18 new new JJ cord-010119-t1x9gknd 8754 19 adult adult NN cord-010119-t1x9gknd 8754 20 trauma trauma NN cord-010119-t1x9gknd 8754 21 center center NN cord-010119-t1x9gknd 8754 22 . . . cord-010119-t1x9gknd 8755 1 We -PRON- PRP cord-010119-t1x9gknd 8755 2 have have VBP cord-010119-t1x9gknd 8755 3 recently recently RB cord-010119-t1x9gknd 8755 4 begun begin VBN cord-010119-t1x9gknd 8755 5 tracking track VBG cord-010119-t1x9gknd 8755 6 time time NN cord-010119-t1x9gknd 8755 7 to to IN cord-010119-t1x9gknd 8755 8 last last JJ cord-010119-t1x9gknd 8755 9 product product NN cord-010119-t1x9gknd 8755 10 issued issue VBN cord-010119-t1x9gknd 8755 11 during during IN cord-010119-t1x9gknd 8755 12 an an DT cord-010119-t1x9gknd 8755 13 MTP MTP NNP cord-010119-t1x9gknd 8755 14 , , , cord-010119-t1x9gknd 8755 15 but but CC cord-010119-t1x9gknd 8755 16 can can MD cord-010119-t1x9gknd 8755 17 not not RB cord-010119-t1x9gknd 8755 18 report report VB cord-010119-t1x9gknd 8755 19 on on IN cord-010119-t1x9gknd 8755 20 that that DT cord-010119-t1x9gknd 8755 21 variable variable NN cord-010119-t1x9gknd 8755 22 at at IN cord-010119-t1x9gknd 8755 23 this this DT cord-010119-t1x9gknd 8755 24 time time NN cord-010119-t1x9gknd 8755 25 . . . cord-010119-t1x9gknd 8756 1 Overall overall RB cord-010119-t1x9gknd 8756 2 , , , cord-010119-t1x9gknd 8756 3 our -PRON- PRP$ cord-010119-t1x9gknd 8756 4 data datum NNS cord-010119-t1x9gknd 8756 5 show show VBP cord-010119-t1x9gknd 8756 6 that that IN cord-010119-t1x9gknd 8756 7 our -PRON- PRP$ cord-010119-t1x9gknd 8756 8 transfusion transfusion NN cord-010119-t1x9gknd 8756 9 service service NN cord-010119-t1x9gknd 8756 10 is be VBZ cord-010119-t1x9gknd 8756 11 generally generally RB cord-010119-t1x9gknd 8756 12 performing perform VBG cord-010119-t1x9gknd 8756 13 adequately adequately RB cord-010119-t1x9gknd 8756 14 to to TO cord-010119-t1x9gknd 8756 15 issue issue VB cord-010119-t1x9gknd 8756 16 the the DT cord-010119-t1x9gknd 8756 17 first first JJ cord-010119-t1x9gknd 8756 18 product product NN cord-010119-t1x9gknd 8756 19 within within IN cord-010119-t1x9gknd 8756 20 10 10 CD cord-010119-t1x9gknd 8756 21 minutes minute NNS cord-010119-t1x9gknd 8756 22 of of IN cord-010119-t1x9gknd 8756 23 MTP MTP NNP cord-010119-t1x9gknd 8756 24 protocol protocol NN cord-010119-t1x9gknd 8756 25 activation activation NN cord-010119-t1x9gknd 8756 26 . . . cord-010119-t1x9gknd 8757 1 This this DT cord-010119-t1x9gknd 8757 2 data datum NNS cord-010119-t1x9gknd 8757 3 only only RB cord-010119-t1x9gknd 8757 4 reflects reflect VBZ cord-010119-t1x9gknd 8757 5 time time NN cord-010119-t1x9gknd 8757 6 to to TO cord-010119-t1x9gknd 8757 7 issue issue VB cord-010119-t1x9gknd 8757 8 in in IN cord-010119-t1x9gknd 8757 9 the the DT cord-010119-t1x9gknd 8757 10 PTS PTS NNP cord-010119-t1x9gknd 8757 11 ; ; , cord-010119-t1x9gknd 8757 12 patient patient JJ cord-010119-t1x9gknd 8757 13 care care NN cord-010119-t1x9gknd 8757 14 areas area NNS cord-010119-t1x9gknd 8757 15 can can MD cord-010119-t1x9gknd 8757 16 experience experience VB cord-010119-t1x9gknd 8757 17 additional additional JJ cord-010119-t1x9gknd 8757 18 minutes minute NNS cord-010119-t1x9gknd 8757 19 delay delay NN cord-010119-t1x9gknd 8757 20 in in IN cord-010119-t1x9gknd 8757 21 PTS PTS NNP cord-010119-t1x9gknd 8757 22 delivery delivery NN cord-010119-t1x9gknd 8757 23 and and CC cord-010119-t1x9gknd 8757 24 arrival arrival NN cord-010119-t1x9gknd 8757 25 of of IN cord-010119-t1x9gknd 8757 26 product product NN cord-010119-t1x9gknd 8757 27 at at IN cord-010119-t1x9gknd 8757 28 bedside bedside NN cord-010119-t1x9gknd 8757 29 . . . cord-010119-t1x9gknd 8758 1 We -PRON- PRP cord-010119-t1x9gknd 8758 2 must must MD cord-010119-t1x9gknd 8758 3 continue continue VB cord-010119-t1x9gknd 8758 4 to to TO cord-010119-t1x9gknd 8758 5 collaborate collaborate VB cord-010119-t1x9gknd 8758 6 with with IN cord-010119-t1x9gknd 8758 7 our -PRON- PRP$ cord-010119-t1x9gknd 8758 8 clinical clinical JJ cord-010119-t1x9gknd 8758 9 colleagues colleague NNS cord-010119-t1x9gknd 8758 10 to to TO cord-010119-t1x9gknd 8758 11 collect collect VB cord-010119-t1x9gknd 8758 12 accurate accurate JJ cord-010119-t1x9gknd 8758 13 data datum NNS cord-010119-t1x9gknd 8758 14 to to TO cord-010119-t1x9gknd 8758 15 provide provide VB cord-010119-t1x9gknd 8758 16 the the DT cord-010119-t1x9gknd 8758 17 best good JJS cord-010119-t1x9gknd 8758 18 and and CC cord-010119-t1x9gknd 8758 19 most most RBS cord-010119-t1x9gknd 8758 20 efficient efficient JJ cord-010119-t1x9gknd 8758 21 MTP MTP NNP cord-010119-t1x9gknd 8758 22 care care NN cord-010119-t1x9gknd 8758 23 . . . cord-010119-t1x9gknd 8759 1 Mehreen Mehreen NNP cord-010119-t1x9gknd 8759 2 Yasin Yasin NNP cord-010119-t1x9gknd 8759 3 * * NFP cord-010119-t1x9gknd 8759 4 1 1 CD cord-010119-t1x9gknd 8759 5 , , , cord-010119-t1x9gknd 8759 6 Shailesh Shailesh NNP cord-010119-t1x9gknd 8759 7 Macwan Macwan NNP cord-010119-t1x9gknd 8759 8 1 1 CD cord-010119-t1x9gknd 8759 9 , , , cord-010119-t1x9gknd 8759 10 Arline Arline NNP cord-010119-t1x9gknd 8759 11 Stein Stein NNP cord-010119-t1x9gknd 8759 12 1 1 CD cord-010119-t1x9gknd 8759 13 , , , cord-010119-t1x9gknd 8759 14 Jane Jane NNP cord-010119-t1x9gknd 8759 15 Fischman Fischman NNP cord-010119-t1x9gknd 8759 16 1 1 CD cord-010119-t1x9gknd 8759 17 , , , cord-010119-t1x9gknd 8759 18 Nancy Nancy NNP cord-010119-t1x9gknd 8759 19 Nikolis Nikolis NNP cord-010119-t1x9gknd 8759 20 1 1 CD cord-010119-t1x9gknd 8759 21 , , , cord-010119-t1x9gknd 8759 22 Matthew Matthew NNP cord-010119-t1x9gknd 8759 23 Bank Bank NNP cord-010119-t1x9gknd 8759 24 1 1 CD cord-010119-t1x9gknd 8759 25 , , , cord-010119-t1x9gknd 8759 26 Lennart Lennart NNP cord-010119-t1x9gknd 8759 27 Logdberg Logdberg NNP cord-010119-t1x9gknd 8759 28 1 1 CD cord-010119-t1x9gknd 8759 29 , , , cord-010119-t1x9gknd 8759 30 Alexander Alexander NNP cord-010119-t1x9gknd 8759 31 Indrikovs Indrikovs NNP cord-010119-t1x9gknd 8759 32 2 2 CD cord-010119-t1x9gknd 8759 33 , , , cord-010119-t1x9gknd 8759 34 Sherry Sherry NNP cord-010119-t1x9gknd 8759 35 Shariatmadar Shariatmadar NNP cord-010119-t1x9gknd 8759 36 1 1 CD cord-010119-t1x9gknd 8759 37 and and CC cord-010119-t1x9gknd 8759 38 Vishesh Vishesh NNP cord-010119-t1x9gknd 8759 39 Chhibber Chhibber NNP cord-010119-t1x9gknd 8759 40 1 1 CD cord-010119-t1x9gknd 8759 41 . . . cord-010119-t1x9gknd 8760 1 1 1 CD cord-010119-t1x9gknd 8760 2 North North NNP cord-010119-t1x9gknd 8760 3 Shore Shore NNP cord-010119-t1x9gknd 8760 4 University University NNP cord-010119-t1x9gknd 8760 5 Hospital Hospital NNP cord-010119-t1x9gknd 8760 6 , , , cord-010119-t1x9gknd 8760 7 2 2 CD cord-010119-t1x9gknd 8760 8 Northwell Northwell NNP cord-010119-t1x9gknd 8760 9 Health Health NNP cord-010119-t1x9gknd 8760 10 Background Background NNP cord-010119-t1x9gknd 8760 11 / / SYM cord-010119-t1x9gknd 8760 12 Case Case NNP cord-010119-t1x9gknd 8760 13 Studies Studies NNPS cord-010119-t1x9gknd 8760 14 : : : cord-010119-t1x9gknd 8760 15 Massive massive JJ cord-010119-t1x9gknd 8760 16 bleeding bleeding NN cord-010119-t1x9gknd 8760 17 is be VBZ cord-010119-t1x9gknd 8760 18 generally generally RB cord-010119-t1x9gknd 8760 19 defined define VBN cord-010119-t1x9gknd 8760 20 as as IN cord-010119-t1x9gknd 8760 21 any any DT cord-010119-t1x9gknd 8760 22 patient patient NN cord-010119-t1x9gknd 8760 23 who who WP cord-010119-t1x9gknd 8760 24 requires require VBZ cord-010119-t1x9gknd 8760 25 1 1 CD cord-010119-t1x9gknd 8760 26 blood blood NN cord-010119-t1x9gknd 8760 27 volume volume NN cord-010119-t1x9gknd 8760 28 replacement replacement NN cord-010119-t1x9gknd 8760 29 within within IN cord-010119-t1x9gknd 8760 30 24 24 CD cord-010119-t1x9gknd 8760 31 hours hour NNS cord-010119-t1x9gknd 8760 32 and/or and/or CC cord-010119-t1x9gknd 8760 33 receives receive VBZ cord-010119-t1x9gknd 8760 34 transfusion transfusion NN cord-010119-t1x9gknd 8760 35 of of IN cord-010119-t1x9gknd 8760 36 greater great JJR cord-010119-t1x9gknd 8760 37 than than IN cord-010119-t1x9gknd 8760 38 or or CC cord-010119-t1x9gknd 8760 39 equal equal JJ cord-010119-t1x9gknd 8760 40 to to IN cord-010119-t1x9gknd 8760 41 4 4 CD cord-010119-t1x9gknd 8760 42 units unit NNS cord-010119-t1x9gknd 8760 43 in in IN cord-010119-t1x9gknd 8760 44 one one CD cord-010119-t1x9gknd 8760 45 hour hour NN cord-010119-t1x9gknd 8760 46 with with IN cord-010119-t1x9gknd 8760 47 177A 177a CD cord-010119-t1x9gknd 8760 48 TRANSFUSION transfusion NN cord-010119-t1x9gknd 8760 49 2017 2017 CD cord-010119-t1x9gknd 8760 50 Vol Vol NNP cord-010119-t1x9gknd 8760 51 . . . cord-010119-t1x9gknd 8761 1 57 57 CD cord-010119-t1x9gknd 8761 2 Supplement supplement NN cord-010119-t1x9gknd 8761 3 S3 S3 NNP cord-010119-t1x9gknd 8761 4 ongoing ongoing JJ cord-010119-t1x9gknd 8761 5 bleeding bleeding NN cord-010119-t1x9gknd 8761 6 . . . cord-010119-t1x9gknd 8762 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8762 2 MTP MTP NNP cord-010119-t1x9gknd 8762 3 was be VBD cord-010119-t1x9gknd 8762 4 officially officially RB cord-010119-t1x9gknd 8762 5 implemented implement VBN cord-010119-t1x9gknd 8762 6 in in IN cord-010119-t1x9gknd 8762 7 2013 2013 CD cord-010119-t1x9gknd 8762 8 in in IN cord-010119-t1x9gknd 8762 9 preparation preparation NN cord-010119-t1x9gknd 8762 10 for for IN cord-010119-t1x9gknd 8762 11 an an DT cord-010119-t1x9gknd 8762 12 initial initial JJ cord-010119-t1x9gknd 8762 13 verification verification NN cord-010119-t1x9gknd 8762 14 as as IN cord-010119-t1x9gknd 8762 15 a a DT cord-010119-t1x9gknd 8762 16 Level Level NNP cord-010119-t1x9gknd 8762 17 1 1 CD cord-010119-t1x9gknd 8762 18 Trauma Trauma NNP cord-010119-t1x9gknd 8762 19 Center Center NNP cord-010119-t1x9gknd 8762 20 by by IN cord-010119-t1x9gknd 8762 21 ACS ACS NNP cord-010119-t1x9gknd 8762 22 . . . cord-010119-t1x9gknd 8763 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8763 2 MTP MTP NNP cord-010119-t1x9gknd 8763 3 has have VBZ cord-010119-t1x9gknd 8763 4 the the DT cord-010119-t1x9gknd 8763 5 following follow VBG cord-010119-t1x9gknd 8763 6 packages package NNS cord-010119-t1x9gknd 8763 7 : : : cord-010119-t1x9gknd 8764 1 1st 1st JJ cord-010119-t1x9gknd 8764 2 pack pack NN cord-010119-t1x9gknd 8764 3 has have VBZ cord-010119-t1x9gknd 8764 4 a a DT cord-010119-t1x9gknd 8764 5 ratio ratio NN cord-010119-t1x9gknd 8764 6 of of IN cord-010119-t1x9gknd 8764 7 4:4:1 4:4:1 CD cord-010119-t1x9gknd 8764 8 ( ( -LRB- cord-010119-t1x9gknd 8764 9 RBCS RBCS NNP cord-010119-t1x9gknd 8764 10 , , , cord-010119-t1x9gknd 8764 11 Plasma Plasma NNP cord-010119-t1x9gknd 8764 12 & & CC cord-010119-t1x9gknd 8764 13 Platelets Platelets NNPS cord-010119-t1x9gknd 8764 14 ) ) -RRB- cord-010119-t1x9gknd 8764 15 and and CC cord-010119-t1x9gknd 8764 16 subsequent subsequent JJ cord-010119-t1x9gknd 8764 17 packs pack NNS cord-010119-t1x9gknd 8764 18 a a DT cord-010119-t1x9gknd 8764 19 ratio ratio NN cord-010119-t1x9gknd 8764 20 of of IN cord-010119-t1x9gknd 8764 21 6:6:1 6:6:1 CD cord-010119-t1x9gknd 8764 22 . . . cord-010119-t1x9gknd 8765 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8765 2 MTP MTP NNP cord-010119-t1x9gknd 8765 3 also also RB cord-010119-t1x9gknd 8765 4 includes include VBZ cord-010119-t1x9gknd 8765 5 Prothrombin Prothrombin NNP cord-010119-t1x9gknd 8765 6 Time Time NNP cord-010119-t1x9gknd 8765 7 ( ( -LRB- cord-010119-t1x9gknd 8765 8 PT PT NNP cord-010119-t1x9gknd 8765 9 ) ) -RRB- cord-010119-t1x9gknd 8765 10 , , , cord-010119-t1x9gknd 8765 11 activated activate VBD cord-010119-t1x9gknd 8765 12 Partial Partial NNP cord-010119-t1x9gknd 8765 13 Thromboplastin Thromboplastin NNP cord-010119-t1x9gknd 8765 14 Time Time NNP cord-010119-t1x9gknd 8765 15 ( ( -LRB- cord-010119-t1x9gknd 8765 16 aPTT aptt NN cord-010119-t1x9gknd 8765 17 ) ) -RRB- cord-010119-t1x9gknd 8765 18 and and CC cord-010119-t1x9gknd 8765 19 Fibrinogen Fibrinogen NNP cord-010119-t1x9gknd 8765 20 testing testing NN cord-010119-t1x9gknd 8765 21 after after IN cord-010119-t1x9gknd 8765 22 each each DT cord-010119-t1x9gknd 8765 23 pack pack NN cord-010119-t1x9gknd 8765 24 is be VBZ cord-010119-t1x9gknd 8765 25 transfused transfuse VBN cord-010119-t1x9gknd 8765 26 . . . cord-010119-t1x9gknd 8766 1 This this DT cord-010119-t1x9gknd 8766 2 data data NN cord-010119-t1x9gknd 8766 3 is be VBZ cord-010119-t1x9gknd 8766 4 used use VBN cord-010119-t1x9gknd 8766 5 to to TO cord-010119-t1x9gknd 8766 6 assess assess VB cord-010119-t1x9gknd 8766 7 the the DT cord-010119-t1x9gknd 8766 8 patient patient NN cord-010119-t1x9gknd 8766 9 and and CC cord-010119-t1x9gknd 8766 10 allows allow VBZ cord-010119-t1x9gknd 8766 11 the the DT cord-010119-t1x9gknd 8766 12 transfusion transfusion NN cord-010119-t1x9gknd 8766 13 service service NN cord-010119-t1x9gknd 8766 14 and and CC cord-010119-t1x9gknd 8766 15 clinical clinical JJ cord-010119-t1x9gknd 8766 16 team team NN cord-010119-t1x9gknd 8766 17 to to TO cord-010119-t1x9gknd 8766 18 identify identify VB cord-010119-t1x9gknd 8766 19 coagulopathies coagulopathie NNS cord-010119-t1x9gknd 8766 20 . . . cord-010119-t1x9gknd 8767 1 However however RB cord-010119-t1x9gknd 8767 2 , , , cord-010119-t1x9gknd 8767 3 attempts attempt VBZ cord-010119-t1x9gknd 8767 4 to to TO cord-010119-t1x9gknd 8767 5 supplement supplement VB cord-010119-t1x9gknd 8767 6 MTP MTP NNP cord-010119-t1x9gknd 8767 7 packs pack NNS cord-010119-t1x9gknd 8767 8 with with IN cord-010119-t1x9gknd 8767 9 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 8767 10 ( ( -LRB- cord-010119-t1x9gknd 8767 11 CRYO CRYO NNP cord-010119-t1x9gknd 8767 12 ) ) -RRB- cord-010119-t1x9gknd 8767 13 and and CC cord-010119-t1x9gknd 8767 14 prothrombin prothrombin NN cord-010119-t1x9gknd 8767 15 complex complex JJ cord-010119-t1x9gknd 8767 16 concentrate concentrate NN cord-010119-t1x9gknd 8767 17 ( ( -LRB- cord-010119-t1x9gknd 8767 18 PCC PCC NNP cord-010119-t1x9gknd 8767 19 ) ) -RRB- cord-010119-t1x9gknd 8767 20 were be VBD cord-010119-t1x9gknd 8767 21 challenging challenge VBG cord-010119-t1x9gknd 8767 22 to to TO cord-010119-t1x9gknd 8767 23 accomplish accomplish VB cord-010119-t1x9gknd 8767 24 in in IN cord-010119-t1x9gknd 8767 25 a a DT cord-010119-t1x9gknd 8767 26 timely timely JJ cord-010119-t1x9gknd 8767 27 manner manner NN cord-010119-t1x9gknd 8767 28 . . . cord-010119-t1x9gknd 8768 1 Study Study NNP cord-010119-t1x9gknd 8768 2 Design Design NNP cord-010119-t1x9gknd 8768 3 / / SYM cord-010119-t1x9gknd 8768 4 Methods method NNS cord-010119-t1x9gknd 8768 5 : : : cord-010119-t1x9gknd 8768 6 Due due IN cord-010119-t1x9gknd 8768 7 to to IN cord-010119-t1x9gknd 8768 8 challenges challenge NNS cord-010119-t1x9gknd 8768 9 in in IN cord-010119-t1x9gknd 8768 10 timely timely JJ cord-010119-t1x9gknd 8768 11 supplementation supplementation NN cord-010119-t1x9gknd 8768 12 of of IN cord-010119-t1x9gknd 8768 13 MTP MTP NNP cord-010119-t1x9gknd 8768 14 packages package NNS cord-010119-t1x9gknd 8768 15 with with IN cord-010119-t1x9gknd 8768 16 CRYO CRYO NNP cord-010119-t1x9gknd 8768 17 and and CC cord-010119-t1x9gknd 8768 18 PCC PCC NNP cord-010119-t1x9gknd 8768 19 , , , cord-010119-t1x9gknd 8768 20 the the DT cord-010119-t1x9gknd 8768 21 protocol protocol NN cord-010119-t1x9gknd 8768 22 was be VBD cord-010119-t1x9gknd 8768 23 modified modify VBN cord-010119-t1x9gknd 8768 24 in in IN cord-010119-t1x9gknd 8768 25 March March NNP cord-010119-t1x9gknd 8768 26 2016 2016 CD cord-010119-t1x9gknd 8768 27 to to TO cord-010119-t1x9gknd 8768 28 add add VB cord-010119-t1x9gknd 8768 29 CRYO CRYO NNP cord-010119-t1x9gknd 8768 30 and and CC cord-010119-t1x9gknd 8768 31 PCC PCC NNP cord-010119-t1x9gknd 8768 32 at at IN cord-010119-t1x9gknd 8768 33 a a DT cord-010119-t1x9gknd 8768 34 defined define VBN cord-010119-t1x9gknd 8768 35 point point NN cord-010119-t1x9gknd 8768 36 in in IN cord-010119-t1x9gknd 8768 37 the the DT cord-010119-t1x9gknd 8768 38 MTP MTP NNP cord-010119-t1x9gknd 8768 39 ( ( -LRB- cord-010119-t1x9gknd 8768 40 CRYO CRYO NNP cord-010119-t1x9gknd 8768 41 is be VBZ cord-010119-t1x9gknd 8768 42 included include VBN cord-010119-t1x9gknd 8768 43 in in IN cord-010119-t1x9gknd 8768 44 the the DT cord-010119-t1x9gknd 8768 45 3rd 3rd JJ cord-010119-t1x9gknd 8768 46 pack pack NN cord-010119-t1x9gknd 8768 47 and and CC cord-010119-t1x9gknd 8768 48 PCC PCC NNP cord-010119-t1x9gknd 8768 49 in in IN cord-010119-t1x9gknd 8768 50 the the DT cord-010119-t1x9gknd 8768 51 4th 4th JJ cord-010119-t1x9gknd 8768 52 pack pack NN cord-010119-t1x9gknd 8768 53 ) ) -RRB- cord-010119-t1x9gknd 8768 54 . . . cord-010119-t1x9gknd 8769 1 In in IN cord-010119-t1x9gknd 8769 2 order order NN cord-010119-t1x9gknd 8769 3 to to TO cord-010119-t1x9gknd 8769 4 validate validate VB cord-010119-t1x9gknd 8769 5 this this DT cord-010119-t1x9gknd 8769 6 modification modification NN cord-010119-t1x9gknd 8769 7 of of IN cord-010119-t1x9gknd 8769 8 adding add VBG cord-010119-t1x9gknd 8769 9 these these DT cord-010119-t1x9gknd 8769 10 products product NNS cord-010119-t1x9gknd 8769 11 at at IN cord-010119-t1x9gknd 8769 12 defined define VBN cord-010119-t1x9gknd 8769 13 intervals interval NNS cord-010119-t1x9gknd 8769 14 regardless regardless RB cord-010119-t1x9gknd 8769 15 of of IN cord-010119-t1x9gknd 8769 16 laboratory laboratory NN cord-010119-t1x9gknd 8769 17 data datum NNS cord-010119-t1x9gknd 8769 18 , , , cord-010119-t1x9gknd 8769 19 we -PRON- PRP cord-010119-t1x9gknd 8769 20 decided decide VBD cord-010119-t1x9gknd 8769 21 to to TO cord-010119-t1x9gknd 8769 22 review review VB cord-010119-t1x9gknd 8769 23 all all DT cord-010119-t1x9gknd 8769 24 patients patient NNS cord-010119-t1x9gknd 8769 25 that that WDT cord-010119-t1x9gknd 8769 26 received receive VBD cord-010119-t1x9gknd 8769 27 > > XX cord-010119-t1x9gknd 8769 28 20 20 CD cord-010119-t1x9gknd 8769 29 RBC RBC NNP cord-010119-t1x9gknd 8769 30 at at IN cord-010119-t1x9gknd 8769 31 our -PRON- PRP$ cord-010119-t1x9gknd 8769 32 institution institution NN cord-010119-t1x9gknd 8769 33 as as IN cord-010119-t1x9gknd 8769 34 these these DT cord-010119-t1x9gknd 8769 35 massively massively RB cord-010119-t1x9gknd 8769 36 hemorrhaging hemorrhage VBG cord-010119-t1x9gknd 8769 37 patients patient NNS cord-010119-t1x9gknd 8769 38 would would MD cord-010119-t1x9gknd 8769 39 receive receive VB cord-010119-t1x9gknd 8769 40 PCC PCC NNP cord-010119-t1x9gknd 8769 41 based base VBN cord-010119-t1x9gknd 8769 42 on on IN cord-010119-t1x9gknd 8769 43 our -PRON- PRP$ cord-010119-t1x9gknd 8769 44 current current JJ cord-010119-t1x9gknd 8769 45 protocol protocol NN cord-010119-t1x9gknd 8769 46 . . . cord-010119-t1x9gknd 8770 1 We -PRON- PRP cord-010119-t1x9gknd 8770 2 reviewed review VBD cord-010119-t1x9gknd 8770 3 the the DT cord-010119-t1x9gknd 8770 4 blood blood NN cord-010119-t1x9gknd 8770 5 products product NNS cord-010119-t1x9gknd 8770 6 received receive VBN cord-010119-t1x9gknd 8770 7 by by IN cord-010119-t1x9gknd 8770 8 these these DT cord-010119-t1x9gknd 8770 9 patients patient NNS cord-010119-t1x9gknd 8770 10 and and CC cord-010119-t1x9gknd 8770 11 their -PRON- PRP$ cord-010119-t1x9gknd 8770 12 available available JJ cord-010119-t1x9gknd 8770 13 laboratory laboratory NN cord-010119-t1x9gknd 8770 14 data datum NNS cord-010119-t1x9gknd 8770 15 . . . cord-010119-t1x9gknd 8771 1 Results result NNS cord-010119-t1x9gknd 8771 2 / / SYM cord-010119-t1x9gknd 8771 3 Findings finding NNS cord-010119-t1x9gknd 8771 4 : : : cord-010119-t1x9gknd 8772 1 We -PRON- PRP cord-010119-t1x9gknd 8772 2 had have VBD cord-010119-t1x9gknd 8772 3 8 8 CD cord-010119-t1x9gknd 8772 4 patients patient NNS cord-010119-t1x9gknd 8772 5 who who WP cord-010119-t1x9gknd 8772 6 received receive VBD cord-010119-t1x9gknd 8772 7 > > XX cord-010119-t1x9gknd 8772 8 20 20 CD cord-010119-t1x9gknd 8772 9 RBC RBC NNP cord-010119-t1x9gknd 8772 10 in in IN cord-010119-t1x9gknd 8772 11 2015 2015 CD cord-010119-t1x9gknd 8772 12 and and CC cord-010119-t1x9gknd 8772 13 2016 2016 CD cord-010119-t1x9gknd 8772 14 . . . cord-010119-t1x9gknd 8773 1 MTP MTP NNP cord-010119-t1x9gknd 8773 2 had have VBD cord-010119-t1x9gknd 8773 3 been be VBN cord-010119-t1x9gknd 8773 4 activated activate VBN cord-010119-t1x9gknd 8773 5 for for IN cord-010119-t1x9gknd 8773 6 all all DT cord-010119-t1x9gknd 8773 7 patients patient NNS cord-010119-t1x9gknd 8773 8 and and CC cord-010119-t1x9gknd 8773 9 all all DT cord-010119-t1x9gknd 8773 10 patients patient NNS cord-010119-t1x9gknd 8773 11 received receive VBN cord-010119-t1x9gknd 8773 12 between between IN cord-010119-t1x9gknd 8773 13 0.5 0.5 CD cord-010119-t1x9gknd 8773 14 to to TO cord-010119-t1x9gknd 8773 15 1 1 CD cord-010119-t1x9gknd 8773 16 unit unit NN cord-010119-t1x9gknd 8773 17 of of IN cord-010119-t1x9gknd 8773 18 plasma plasma NN cord-010119-t1x9gknd 8773 19 for for IN cord-010119-t1x9gknd 8773 20 each each DT cord-010119-t1x9gknd 8773 21 RBC RBC NNP cord-010119-t1x9gknd 8773 22 unit unit NN cord-010119-t1x9gknd 8773 23 transfused transfuse VBN cord-010119-t1x9gknd 8773 24 . . . cord-010119-t1x9gknd 8774 1 Despite despite IN cord-010119-t1x9gknd 8774 2 receiving receive VBG cord-010119-t1x9gknd 8774 3 these these DT cord-010119-t1x9gknd 8774 4 ratios ratio NNS cord-010119-t1x9gknd 8774 5 of of IN cord-010119-t1x9gknd 8774 6 blood blood NN cord-010119-t1x9gknd 8774 7 products product NNS cord-010119-t1x9gknd 8774 8 , , , cord-010119-t1x9gknd 8774 9 all all DT cord-010119-t1x9gknd 8774 10 patients patient NNS cord-010119-t1x9gknd 8774 11 had have VBD cord-010119-t1x9gknd 8774 12 elevations elevation NNS cord-010119-t1x9gknd 8774 13 of of IN cord-010119-t1x9gknd 8774 14 their -PRON- PRP$ cord-010119-t1x9gknd 8774 15 PT pt NN cord-010119-t1x9gknd 8774 16 > > XX cord-010119-t1x9gknd 8774 17 16 16 CD cord-010119-t1x9gknd 8774 18 seconds second NNS cord-010119-t1x9gknd 8774 19 and and CC cord-010119-t1x9gknd 8774 20 many many JJ cord-010119-t1x9gknd 8774 21 had have VBD cord-010119-t1x9gknd 8774 22 elevations elevation NNS cord-010119-t1x9gknd 8774 23 of of IN cord-010119-t1x9gknd 8774 24 the the DT cord-010119-t1x9gknd 8774 25 aPTT aptt NN cord-010119-t1x9gknd 8774 26 and and CC cord-010119-t1x9gknd 8774 27 fibrinogen fibrinogen NN cord-010119-t1x9gknd 8774 28 levels level NNS cord-010119-t1x9gknd 8774 29 less less JJR cord-010119-t1x9gknd 8774 30 than than IN cord-010119-t1x9gknd 8774 31 our -PRON- PRP$ cord-010119-t1x9gknd 8774 32 institution institution NN cord-010119-t1x9gknd 8774 33 's 's POS cord-010119-t1x9gknd 8774 34 target target NN cord-010119-t1x9gknd 8774 35 of of IN cord-010119-t1x9gknd 8774 36 200 200 CD cord-010119-t1x9gknd 8774 37 mg mg NNP cord-010119-t1x9gknd 8774 38 / / SYM cord-010119-t1x9gknd 8774 39 dL dl NN cord-010119-t1x9gknd 8774 40 ( ( -LRB- cord-010119-t1x9gknd 8774 41 Table table NN cord-010119-t1x9gknd 8774 42 1 1 CD cord-010119-t1x9gknd 8774 43 ) ) -RRB- cord-010119-t1x9gknd 8774 44 . . . cord-010119-t1x9gknd 8775 1 As as IN cord-010119-t1x9gknd 8775 2 anticipated anticipate VBN cord-010119-t1x9gknd 8775 3 , , , cord-010119-t1x9gknd 8775 4 improvement improvement NN cord-010119-t1x9gknd 8775 5 in in IN cord-010119-t1x9gknd 8775 6 the the DT cord-010119-t1x9gknd 8775 7 coagulation coagulation NN cord-010119-t1x9gknd 8775 8 parameters parameter NNS cord-010119-t1x9gknd 8775 9 was be VBD cord-010119-t1x9gknd 8775 10 noted note VBN cord-010119-t1x9gknd 8775 11 with with IN cord-010119-t1x9gknd 8775 12 CRYO CRYO NNP cord-010119-t1x9gknd 8775 13 and and CC cord-010119-t1x9gknd 8775 14 PCC PCC NNP cord-010119-t1x9gknd 8775 15 supplementation supplementation NN cord-010119-t1x9gknd 8775 16 . . . cord-010119-t1x9gknd 8776 1 Conclusion conclusion NN cord-010119-t1x9gknd 8776 2 : : : cord-010119-t1x9gknd 8777 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8777 2 data datum NNS cord-010119-t1x9gknd 8777 3 on on IN cord-010119-t1x9gknd 8777 4 massively massively RB cord-010119-t1x9gknd 8777 5 hemorrhaging hemorrhage VBG cord-010119-t1x9gknd 8777 6 patients patient NNS cord-010119-t1x9gknd 8777 7 supports support VBZ cord-010119-t1x9gknd 8777 8 a a DT cord-010119-t1x9gknd 8777 9 role role NN cord-010119-t1x9gknd 8777 10 for for IN cord-010119-t1x9gknd 8777 11 supplementation supplementation NN cord-010119-t1x9gknd 8777 12 of of IN cord-010119-t1x9gknd 8777 13 our -PRON- PRP$ cord-010119-t1x9gknd 8777 14 MTP MTP NNP cord-010119-t1x9gknd 8777 15 with with IN cord-010119-t1x9gknd 8777 16 CRYO CRYO NNP cord-010119-t1x9gknd 8777 17 and and CC cord-010119-t1x9gknd 8777 18 PCC PCC NNP cord-010119-t1x9gknd 8777 19 in in IN cord-010119-t1x9gknd 8777 20 patients patient NNS cord-010119-t1x9gknd 8777 21 who who WP cord-010119-t1x9gknd 8777 22 require require VBP cord-010119-t1x9gknd 8777 23 transfusion transfusion NN cord-010119-t1x9gknd 8777 24 of of IN cord-010119-t1x9gknd 8777 25 > > $ cord-010119-t1x9gknd 8777 26 20 20 CD cord-010119-t1x9gknd 8777 27 RBC RBC NNP cord-010119-t1x9gknd 8777 28 . . . cord-010119-t1x9gknd 8778 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8778 2 current current JJ cord-010119-t1x9gknd 8778 3 protocol protocol NN cord-010119-t1x9gknd 8778 4 with with IN cord-010119-t1x9gknd 8778 5 the the DT cord-010119-t1x9gknd 8778 6 addition addition NN cord-010119-t1x9gknd 8778 7 of of IN cord-010119-t1x9gknd 8778 8 CRYO CRYO NNP cord-010119-t1x9gknd 8778 9 and and CC cord-010119-t1x9gknd 8778 10 PCC PCC NNP cord-010119-t1x9gknd 8778 11 at at IN cord-010119-t1x9gknd 8778 12 defined define VBN cord-010119-t1x9gknd 8778 13 intervals interval NNS cord-010119-t1x9gknd 8778 14 has have VBZ cord-010119-t1x9gknd 8778 15 streamlined streamline VBN cord-010119-t1x9gknd 8778 16 the the DT cord-010119-t1x9gknd 8778 17 process process NN cord-010119-t1x9gknd 8778 18 and and CC cord-010119-t1x9gknd 8778 19 improved improve VBD cord-010119-t1x9gknd 8778 20 timely timely JJ cord-010119-t1x9gknd 8778 21 provision provision NN cord-010119-t1x9gknd 8778 22 of of IN cord-010119-t1x9gknd 8778 23 these these DT cord-010119-t1x9gknd 8778 24 products product NNS cord-010119-t1x9gknd 8778 25 in in IN cord-010119-t1x9gknd 8778 26 bleeding bleed VBG cord-010119-t1x9gknd 8778 27 coagulopathic coagulopathic JJ cord-010119-t1x9gknd 8778 28 patients patient NNS cord-010119-t1x9gknd 8778 29 . . . cord-010119-t1x9gknd 8779 1 Background Background NNP cord-010119-t1x9gknd 8779 2 / / SYM cord-010119-t1x9gknd 8779 3 Case Case NNP cord-010119-t1x9gknd 8779 4 Studies Studies NNPS cord-010119-t1x9gknd 8779 5 : : : cord-010119-t1x9gknd 8779 6 Red red JJ cord-010119-t1x9gknd 8779 7 blood blood NN cord-010119-t1x9gknd 8779 8 cell cell NN cord-010119-t1x9gknd 8779 9 hemolysis hemolysis NN cord-010119-t1x9gknd 8779 10 is be VBZ cord-010119-t1x9gknd 8779 11 a a DT cord-010119-t1x9gknd 8779 12 key key JJ cord-010119-t1x9gknd 8779 13 finding finding NN cord-010119-t1x9gknd 8779 14 for for IN cord-010119-t1x9gknd 8779 15 a a DT cord-010119-t1x9gknd 8779 16 diagnosis diagnosis NN cord-010119-t1x9gknd 8779 17 of of IN cord-010119-t1x9gknd 8779 18 transplant transplant NN cord-010119-t1x9gknd 8779 19 - - HYPH cord-010119-t1x9gknd 8779 20 associated associate VBN cord-010119-t1x9gknd 8779 21 passenger passenger NN cord-010119-t1x9gknd 8779 22 lymphocyte lymphocyte NN cord-010119-t1x9gknd 8779 23 syndrome syndrome NN cord-010119-t1x9gknd 8779 24 ( ( -LRB- cord-010119-t1x9gknd 8779 25 TA TA NNP cord-010119-t1x9gknd 8779 26 - - HYPH cord-010119-t1x9gknd 8779 27 PLS PLS NNP cord-010119-t1x9gknd 8779 28 ) ) -RRB- cord-010119-t1x9gknd 8779 29 . . . cord-010119-t1x9gknd 8780 1 However however RB cord-010119-t1x9gknd 8780 2 , , , cord-010119-t1x9gknd 8780 3 whether whether IN cord-010119-t1x9gknd 8780 4 a a DT cord-010119-t1x9gknd 8780 5 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 8780 6 stem stem NN cord-010119-t1x9gknd 8780 7 cell cell NN cord-010119-t1x9gknd 8780 8 or or CC cord-010119-t1x9gknd 8780 9 organ organ NN cord-010119-t1x9gknd 8780 10 transplant transplant NN cord-010119-t1x9gknd 8780 11 recipient recipient NN cord-010119-t1x9gknd 8780 12 experiences experience NNS cord-010119-t1x9gknd 8780 13 hemolysis hemolysis VBP cord-010119-t1x9gknd 8780 14 when when WRB cord-010119-t1x9gknd 8780 15 a a DT cord-010119-t1x9gknd 8780 16 transplant transplant NN cord-010119-t1x9gknd 8780 17 contains contain VBZ cord-010119-t1x9gknd 8780 18 unintended unintended JJ cord-010119-t1x9gknd 8780 19 antibody antibody NN cord-010119-t1x9gknd 8780 20 - - HYPH cord-010119-t1x9gknd 8780 21 forming form VBG cord-010119-t1x9gknd 8780 22 passenger passenger NN cord-010119-t1x9gknd 8780 23 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 8781 1 depends depend VBZ cord-010119-t1x9gknd 8781 2 , , , cord-010119-t1x9gknd 8781 3 by by IN cord-010119-t1x9gknd 8781 4 chance chance NN cord-010119-t1x9gknd 8781 5 , , , cord-010119-t1x9gknd 8781 6 on on IN cord-010119-t1x9gknd 8781 7 the the DT cord-010119-t1x9gknd 8781 8 recipient recipient NN cord-010119-t1x9gknd 8781 9 's 's POS cord-010119-t1x9gknd 8781 10 blood blood NN cord-010119-t1x9gknd 8781 11 group group NN cord-010119-t1x9gknd 8781 12 phenotype phenotype NN cord-010119-t1x9gknd 8781 13 . . . cord-010119-t1x9gknd 8782 1 A a DT cord-010119-t1x9gknd 8782 2 living live VBG cord-010119-t1x9gknd 8782 3 donor donor NN cord-010119-t1x9gknd 8782 4 liver liver NN cord-010119-t1x9gknd 8782 5 segment segment NN cord-010119-t1x9gknd 8782 6 transplant transplant NN cord-010119-t1x9gknd 8782 7 resulted result VBD cord-010119-t1x9gknd 8782 8 in in IN cord-010119-t1x9gknd 8782 9 a a DT cord-010119-t1x9gknd 8782 10 case case NN cord-010119-t1x9gknd 8782 11 of of IN cord-010119-t1x9gknd 8782 12 TA TA NNP cord-010119-t1x9gknd 8782 13 - - HYPH cord-010119-t1x9gknd 8782 14 PLS PLS NNP cord-010119-t1x9gknd 8782 15 with with IN cord-010119-t1x9gknd 8782 16 donor donor NN cord-010119-t1x9gknd 8782 17 - - HYPH cord-010119-t1x9gknd 8782 18 derived derive VBN cord-010119-t1x9gknd 8782 19 anti anti JJ cord-010119-t1x9gknd 8782 20 - - JJ cord-010119-t1x9gknd 8782 21 D d JJ cord-010119-t1x9gknd 8782 22 that that WDT cord-010119-t1x9gknd 8782 23 had have VBD cord-010119-t1x9gknd 8782 24 the the DT cord-010119-t1x9gknd 8782 25 potential potential NN cord-010119-t1x9gknd 8782 26 for for IN cord-010119-t1x9gknd 8782 27 causing cause VBG cord-010119-t1x9gknd 8782 28 a a DT cord-010119-t1x9gknd 8782 29 clinically clinically RB cord-010119-t1x9gknd 8782 30 significant significant JJ cord-010119-t1x9gknd 8782 31 hemolytic hemolytic JJ cord-010119-t1x9gknd 8782 32 event event NN cord-010119-t1x9gknd 8782 33 . . . cord-010119-t1x9gknd 8783 1 The the DT cord-010119-t1x9gknd 8783 2 donor donor NN cord-010119-t1x9gknd 8783 3 's 's POS cord-010119-t1x9gknd 8783 4 plasma plasma NN cord-010119-t1x9gknd 8783 5 contained contain VBD cord-010119-t1x9gknd 8783 6 anti anti NNP cord-010119-t1x9gknd 8783 7 - - NNP cord-010119-t1x9gknd 8783 8 D. D. NNP cord-010119-t1x9gknd 8783 9 Anti Anti NNP cord-010119-t1x9gknd 8783 10 - - NNP cord-010119-t1x9gknd 8783 11 D D NNP cord-010119-t1x9gknd 8783 12 was be VBD cord-010119-t1x9gknd 8783 13 absent absent JJ cord-010119-t1x9gknd 8783 14 in in IN cord-010119-t1x9gknd 8783 15 the the DT cord-010119-t1x9gknd 8783 16 recipient recipient NN cord-010119-t1x9gknd 8783 17 's 's POS cord-010119-t1x9gknd 8783 18 pre pre JJ cord-010119-t1x9gknd 8783 19 - - JJ cord-010119-t1x9gknd 8783 20 transplant transplant JJ cord-010119-t1x9gknd 8783 21 plasma plasma NN cord-010119-t1x9gknd 8783 22 , , , cord-010119-t1x9gknd 8783 23 but but CC cord-010119-t1x9gknd 8783 24 present present JJ cord-010119-t1x9gknd 8783 25 in in IN cord-010119-t1x9gknd 8783 26 the the DT cord-010119-t1x9gknd 8783 27 recipient recipient NN cord-010119-t1x9gknd 8783 28 's 's POS cord-010119-t1x9gknd 8783 29 5-day 5-day JJ cord-010119-t1x9gknd 8783 30 and and CC cord-010119-t1x9gknd 8783 31 114-day 114-day CD cord-010119-t1x9gknd 8783 32 post post JJ cord-010119-t1x9gknd 8783 33 - - JJ cord-010119-t1x9gknd 8783 34 transplant transplant NN cord-010119-t1x9gknd 8783 35 plasma plasma NN cord-010119-t1x9gknd 8783 36 . . . cord-010119-t1x9gknd 8784 1 Although although IN cord-010119-t1x9gknd 8784 2 these these DT cord-010119-t1x9gknd 8784 3 findings finding NNS cord-010119-t1x9gknd 8784 4 established establish VBD cord-010119-t1x9gknd 8784 5 a a DT cord-010119-t1x9gknd 8784 6 diagnosis diagnosis NN cord-010119-t1x9gknd 8784 7 of of IN cord-010119-t1x9gknd 8784 8 TA TA NNP cord-010119-t1x9gknd 8784 9 - - HYPH cord-010119-t1x9gknd 8784 10 PLS PLS NNP cord-010119-t1x9gknd 8784 11 , , , cord-010119-t1x9gknd 8784 12 hemolysis hemolysis NN cord-010119-t1x9gknd 8784 13 did do VBD cord-010119-t1x9gknd 8784 14 not not RB cord-010119-t1x9gknd 8784 15 occur occur VB cord-010119-t1x9gknd 8784 16 because because IN cord-010119-t1x9gknd 8784 17 the the DT cord-010119-t1x9gknd 8784 18 recipient recipient NN cord-010119-t1x9gknd 8784 19 's 's POS cord-010119-t1x9gknd 8784 20 blood blood NN cord-010119-t1x9gknd 8784 21 group group NN cord-010119-t1x9gknd 8784 22 phenotype phenotype NN cord-010119-t1x9gknd 8784 23 was be VBD cord-010119-t1x9gknd 8784 24 D- d- XX cord-010119-t1x9gknd 8784 25 . . . cord-010119-t1x9gknd 8785 1 The the DT cord-010119-t1x9gknd 8785 2 conventional conventional JJ cord-010119-t1x9gknd 8785 3 focus focus NN cord-010119-t1x9gknd 8785 4 on on IN cord-010119-t1x9gknd 8785 5 hemolysis hemolysis NN cord-010119-t1x9gknd 8785 6 , , , cord-010119-t1x9gknd 8785 7 rather rather RB cord-010119-t1x9gknd 8785 8 than than IN cord-010119-t1x9gknd 8785 9 on on IN cord-010119-t1x9gknd 8785 10 the the DT cord-010119-t1x9gknd 8785 11 transfer transfer NN cord-010119-t1x9gknd 8785 12 of of IN cord-010119-t1x9gknd 8785 13 antibody antibody NN cord-010119-t1x9gknd 8785 14 - - HYPH cord-010119-t1x9gknd 8785 15 forming form VBG cord-010119-t1x9gknd 8785 16 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 8785 17 , , , cord-010119-t1x9gknd 8785 18 is be VBZ cord-010119-t1x9gknd 8785 19 a a DT cord-010119-t1x9gknd 8785 20 diversion diversion NN cord-010119-t1x9gknd 8785 21 from from IN cord-010119-t1x9gknd 8785 22 the the DT cord-010119-t1x9gknd 8785 23 primary primary JJ cord-010119-t1x9gknd 8785 24 pathophysiology pathophysiology NN cord-010119-t1x9gknd 8785 25 of of IN cord-010119-t1x9gknd 8785 26 PLS PLS NNP cord-010119-t1x9gknd 8785 27 and and CC cord-010119-t1x9gknd 8785 28 limits limit NNS cord-010119-t1x9gknd 8785 29 capturing capture VBG cord-010119-t1x9gknd 8785 30 the the DT cord-010119-t1x9gknd 8785 31 true true JJ cord-010119-t1x9gknd 8785 32 scope scope NN cord-010119-t1x9gknd 8785 33 of of IN cord-010119-t1x9gknd 8785 34 the the DT cord-010119-t1x9gknd 8785 35 syndrome syndrome NN cord-010119-t1x9gknd 8785 36 . . . cord-010119-t1x9gknd 8786 1 Study Study NNP cord-010119-t1x9gknd 8786 2 Design Design NNP cord-010119-t1x9gknd 8786 3 / / SYM cord-010119-t1x9gknd 8786 4 Method method NN cord-010119-t1x9gknd 8786 5 : : : cord-010119-t1x9gknd 8787 1 To to TO cord-010119-t1x9gknd 8787 2 determine determine VB cord-010119-t1x9gknd 8787 3 the the DT cord-010119-t1x9gknd 8787 4 standard standard NN cord-010119-t1x9gknd 8787 5 of of IN cord-010119-t1x9gknd 8787 6 practice practice NN cord-010119-t1x9gknd 8787 7 for for IN cord-010119-t1x9gknd 8787 8 detecting detect VBG cord-010119-t1x9gknd 8787 9 and and CC cord-010119-t1x9gknd 8787 10 diagnosing diagnose VBG cord-010119-t1x9gknd 8787 11 TA TA NNP cord-010119-t1x9gknd 8787 12 - - HYPH cord-010119-t1x9gknd 8787 13 PLS PLS NNP cord-010119-t1x9gknd 8787 14 , , , cord-010119-t1x9gknd 8787 15 a a DT cord-010119-t1x9gknd 8787 16 retrospective retrospective JJ cord-010119-t1x9gknd 8787 17 10-year 10-year CD cord-010119-t1x9gknd 8787 18 PubMed PubMed NNP cord-010119-t1x9gknd 8787 19 search search NN cord-010119-t1x9gknd 8787 20 for for IN cord-010119-t1x9gknd 8787 21 peerreviewed peerreviewed JJ cord-010119-t1x9gknd 8787 22 English English NNP cord-010119-t1x9gknd 8787 23 - - HYPH cord-010119-t1x9gknd 8787 24 language language NN cord-010119-t1x9gknd 8787 25 journal journal NN cord-010119-t1x9gknd 8787 26 articles article NNS cord-010119-t1x9gknd 8787 27 was be VBD cord-010119-t1x9gknd 8787 28 conducted conduct VBN cord-010119-t1x9gknd 8787 29 using use VBG cord-010119-t1x9gknd 8787 30 key key JJ cord-010119-t1x9gknd 8787 31 words word NNS cord-010119-t1x9gknd 8787 32 " " `` cord-010119-t1x9gknd 8787 33 passenger passenger NN cord-010119-t1x9gknd 8787 34 lymphocyte lymphocyte NN cord-010119-t1x9gknd 8787 35 syndrome syndrome NN cord-010119-t1x9gknd 8787 36 . . . cord-010119-t1x9gknd 8788 1 " " `` cord-010119-t1x9gknd 8788 2 Cases case NNS cord-010119-t1x9gknd 8788 3 were be VBD cord-010119-t1x9gknd 8788 4 categorized categorize VBN cord-010119-t1x9gknd 8788 5 according accord VBG cord-010119-t1x9gknd 8788 6 to to IN cord-010119-t1x9gknd 8788 7 the the DT cord-010119-t1x9gknd 8788 8 presence presence NN cord-010119-t1x9gknd 8788 9 or or CC cord-010119-t1x9gknd 8788 10 absence absence NN cord-010119-t1x9gknd 8788 11 of of IN cord-010119-t1x9gknd 8788 12 hemolysis hemolysis NN cord-010119-t1x9gknd 8788 13 and and CC cord-010119-t1x9gknd 8788 14 whether whether IN cord-010119-t1x9gknd 8788 15 there there EX cord-010119-t1x9gknd 8788 16 was be VBD cord-010119-t1x9gknd 8788 17 a a DT cord-010119-t1x9gknd 8788 18 routine routine JJ cord-010119-t1x9gknd 8788 19 antibody antibody NN cord-010119-t1x9gknd 8788 20 screen screen NN cord-010119-t1x9gknd 8788 21 to to TO cord-010119-t1x9gknd 8788 22 detect detect VB cord-010119-t1x9gknd 8788 23 donor donor NN cord-010119-t1x9gknd 8788 24 - - HYPH cord-010119-t1x9gknd 8788 25 derived derive VBN cord-010119-t1x9gknd 8788 26 , , , cord-010119-t1x9gknd 8788 27 passenger passenger NN cord-010119-t1x9gknd 8788 28 lymphocyte lymphocyte NN cord-010119-t1x9gknd 8788 29 - - HYPH cord-010119-t1x9gknd 8788 30 formed form VBN cord-010119-t1x9gknd 8788 31 blood blood NN cord-010119-t1x9gknd 8788 32 group group NN cord-010119-t1x9gknd 8788 33 antibodies antibody NNS cord-010119-t1x9gknd 8788 34 . . . cord-010119-t1x9gknd 8789 1 Results result NNS cord-010119-t1x9gknd 8789 2 / / SYM cord-010119-t1x9gknd 8789 3 Finding finding NN cord-010119-t1x9gknd 8789 4 : : : cord-010119-t1x9gknd 8790 1 Of of IN cord-010119-t1x9gknd 8790 2 63 63 CD cord-010119-t1x9gknd 8790 3 published publish VBN cord-010119-t1x9gknd 8790 4 cases case NNS cord-010119-t1x9gknd 8790 5 ( ( -LRB- cord-010119-t1x9gknd 8790 6 31 31 CD cord-010119-t1x9gknd 8790 7 reports report NNS cord-010119-t1x9gknd 8790 8 ) ) -RRB- cord-010119-t1x9gknd 8790 9 of of IN cord-010119-t1x9gknd 8790 10 TA TA NNP cord-010119-t1x9gknd 8790 11 - - HYPH cord-010119-t1x9gknd 8790 12 PLS PLS NNP cord-010119-t1x9gknd 8790 13 , , , cord-010119-t1x9gknd 8790 14 8 8 CD cord-010119-t1x9gknd 8790 15 ( ( -LRB- cord-010119-t1x9gknd 8790 16 4 4 CD cord-010119-t1x9gknd 8790 17 reports report NNS cord-010119-t1x9gknd 8790 18 ) ) -RRB- cord-010119-t1x9gknd 8790 19 were be VBD cord-010119-t1x9gknd 8790 20 stem stem NN cord-010119-t1x9gknd 8790 21 cell cell NN cord-010119-t1x9gknd 8790 22 and and CC cord-010119-t1x9gknd 8790 23 55 55 CD cord-010119-t1x9gknd 8790 24 ( ( -LRB- cord-010119-t1x9gknd 8790 25 27 27 CD cord-010119-t1x9gknd 8790 26 reports report NNS cord-010119-t1x9gknd 8790 27 ) ) -RRB- cord-010119-t1x9gknd 8790 28 were be VBD cord-010119-t1x9gknd 8790 29 organ organ NN cord-010119-t1x9gknd 8790 30 transplants transplant NNS cord-010119-t1x9gknd 8790 31 . . . cord-010119-t1x9gknd 8791 1 All all DT cord-010119-t1x9gknd 8791 2 8(100 8(100 CD cord-010119-t1x9gknd 8791 3 % % NN cord-010119-t1x9gknd 8791 4 ) ) -RRB- cord-010119-t1x9gknd 8791 5 stem stem NN cord-010119-t1x9gknd 8791 6 cell cell NN cord-010119-t1x9gknd 8791 7 transplants transplant NNS cord-010119-t1x9gknd 8791 8 and and CC cord-010119-t1x9gknd 8791 9 52 52 CD cord-010119-t1x9gknd 8791 10 ( ( -LRB- cord-010119-t1x9gknd 8791 11 95 95 CD cord-010119-t1x9gknd 8791 12 % % NN cord-010119-t1x9gknd 8791 13 ) ) -RRB- cord-010119-t1x9gknd 8791 14 organ organ NN cord-010119-t1x9gknd 8791 15 transplants transplant NNS cord-010119-t1x9gknd 8791 16 were be VBD cord-010119-t1x9gknd 8791 17 associated associate VBN cord-010119-t1x9gknd 8791 18 with with IN cord-010119-t1x9gknd 8791 19 hemolysis hemolysis NN cord-010119-t1x9gknd 8791 20 , , , cord-010119-t1x9gknd 8791 21 reflecting reflect VBG cord-010119-t1x9gknd 8791 22 an an DT cord-010119-t1x9gknd 8791 23 overwhelming overwhelming JJ cord-010119-t1x9gknd 8791 24 bias bias NN cord-010119-t1x9gknd 8791 25 for for IN cord-010119-t1x9gknd 8791 26 identifying identify VBG cord-010119-t1x9gknd 8791 27 TA TA NNP cord-010119-t1x9gknd 8791 28 - - HYPH cord-010119-t1x9gknd 8791 29 PLS PLS NNP cord-010119-t1x9gknd 8791 30 associated associate VBD cord-010119-t1x9gknd 8791 31 with with IN cord-010119-t1x9gknd 8791 32 hemolysis hemolysis NN cord-010119-t1x9gknd 8791 33 . . . cord-010119-t1x9gknd 8792 1 Of of IN cord-010119-t1x9gknd 8792 2 the the DT cord-010119-t1x9gknd 8792 3 4 4 CD cord-010119-t1x9gknd 8792 4 reports report NNS cord-010119-t1x9gknd 8792 5 of of IN cord-010119-t1x9gknd 8792 6 stem stem NN cord-010119-t1x9gknd 8792 7 cell cell NN cord-010119-t1x9gknd 8792 8 TA TA NNP cord-010119-t1x9gknd 8792 9 - - HYPH cord-010119-t1x9gknd 8792 10 PLS PLS NNP cord-010119-t1x9gknd 8792 11 , , , cord-010119-t1x9gknd 8792 12 3 3 CD cord-010119-t1x9gknd 8792 13 actively actively RB cord-010119-t1x9gknd 8792 14 screened screen VBN cord-010119-t1x9gknd 8792 15 for for IN cord-010119-t1x9gknd 8792 16 antibodies antibody NNS cord-010119-t1x9gknd 8792 17 in in IN cord-010119-t1x9gknd 8792 18 the the DT cord-010119-t1x9gknd 8792 19 immediate immediate JJ cord-010119-t1x9gknd 8792 20 post post JJ cord-010119-t1x9gknd 8792 21 - - JJ cord-010119-t1x9gknd 8792 22 transplant transplant JJ cord-010119-t1x9gknd 8792 23 period period NN cord-010119-t1x9gknd 8792 24 , , , cord-010119-t1x9gknd 8792 25 and and CC cord-010119-t1x9gknd 8792 26 of of IN cord-010119-t1x9gknd 8792 27 the the DT cord-010119-t1x9gknd 8792 28 27 27 CD cord-010119-t1x9gknd 8792 29 reports report NNS cord-010119-t1x9gknd 8792 30 of of IN cord-010119-t1x9gknd 8792 31 organ organ NN cord-010119-t1x9gknd 8792 32 TA TA NNP cord-010119-t1x9gknd 8792 33 - - HYPH cord-010119-t1x9gknd 8792 34 PLS PLS NNP cord-010119-t1x9gknd 8792 35 , , , cord-010119-t1x9gknd 8792 36 1 1 CD cord-010119-t1x9gknd 8792 37 actively actively RB cord-010119-t1x9gknd 8792 38 screened screen VBN cord-010119-t1x9gknd 8792 39 for for IN cord-010119-t1x9gknd 8792 40 antibodies antibody NNS cord-010119-t1x9gknd 8792 41 . . . cord-010119-t1x9gknd 8793 1 These these DT cord-010119-t1x9gknd 8793 2 screens screen NNS cord-010119-t1x9gknd 8793 3 detected detect VBD cord-010119-t1x9gknd 8793 4 5 5 CD cord-010119-t1x9gknd 8793 5 cases case NNS cord-010119-t1x9gknd 8793 6 of of IN cord-010119-t1x9gknd 8793 7 stem stem NN cord-010119-t1x9gknd 8793 8 cell cell NN cord-010119-t1x9gknd 8793 9 TA TA NNP cord-010119-t1x9gknd 8793 10 - - HYPH cord-010119-t1x9gknd 8793 11 PLS PLS NNP cord-010119-t1x9gknd 8793 12 before before IN cord-010119-t1x9gknd 8793 13 hemolysis hemolysis NN cord-010119-t1x9gknd 8793 14 became become VBD cord-010119-t1x9gknd 8793 15 apparent apparent JJ cord-010119-t1x9gknd 8793 16 and and CC cord-010119-t1x9gknd 8793 17 2 2 CD cord-010119-t1x9gknd 8793 18 cases case NNS cord-010119-t1x9gknd 8793 19 of of IN cord-010119-t1x9gknd 8793 20 organ organ NN cord-010119-t1x9gknd 8793 21 TA TA NNP cord-010119-t1x9gknd 8793 22 - - HYPH cord-010119-t1x9gknd 8793 23 PLS PLS NNP cord-010119-t1x9gknd 8793 24 with with IN cord-010119-t1x9gknd 8793 25 antibodies antibody NNS cord-010119-t1x9gknd 8793 26 without without IN cord-010119-t1x9gknd 8793 27 hemolysis hemolysis NN cord-010119-t1x9gknd 8793 28 . . . cord-010119-t1x9gknd 8794 1 It -PRON- PRP cord-010119-t1x9gknd 8794 2 can can MD cord-010119-t1x9gknd 8794 3 be be VB cord-010119-t1x9gknd 8794 4 inferred infer VBN cord-010119-t1x9gknd 8794 5 that that IN cord-010119-t1x9gknd 8794 6 TA TA NNP cord-010119-t1x9gknd 8794 7 - - HYPH cord-010119-t1x9gknd 8794 8 PLS PLS NNP cord-010119-t1x9gknd 8794 9 is be VBZ cord-010119-t1x9gknd 8794 10 currently currently RB cord-010119-t1x9gknd 8794 11 under under RB cord-010119-t1x9gknd 8794 12 - - HYPH cord-010119-t1x9gknd 8794 13 diagnosed diagnose VBN cord-010119-t1x9gknd 8794 14 , , , cord-010119-t1x9gknd 8794 15 because because IN cord-010119-t1x9gknd 8794 16 hemolysis hemolysis NN cord-010119-t1x9gknd 8794 17 is be VBZ cord-010119-t1x9gknd 8794 18 not not RB cord-010119-t1x9gknd 8794 19 consistently consistently RB cord-010119-t1x9gknd 8794 20 present present JJ cord-010119-t1x9gknd 8795 1 and/or and/or CC cord-010119-t1x9gknd 8795 2 antibody antibody NN cord-010119-t1x9gknd 8795 3 screens screen NNS cord-010119-t1x9gknd 8795 4 are be VBP cord-010119-t1x9gknd 8795 5 not not RB cord-010119-t1x9gknd 8795 6 performed perform VBN cord-010119-t1x9gknd 8795 7 routinely routinely RB cord-010119-t1x9gknd 8795 8 . . . cord-010119-t1x9gknd 8796 1 Conclusion conclusion NN cord-010119-t1x9gknd 8796 2 : : : cord-010119-t1x9gknd 8797 1 A a DT cord-010119-t1x9gknd 8797 2 new new JJ cord-010119-t1x9gknd 8797 3 category category NN cord-010119-t1x9gknd 8797 4 of of IN cord-010119-t1x9gknd 8797 5 " " `` cord-010119-t1x9gknd 8797 6 non non JJ cord-010119-t1x9gknd 8797 7 - - JJ cord-010119-t1x9gknd 8797 8 hemolytic hemolytic JJ cord-010119-t1x9gknd 8797 9 TA TA NNP cord-010119-t1x9gknd 8797 10 - - HYPH cord-010119-t1x9gknd 8797 11 PLS PLS NNP cord-010119-t1x9gknd 8797 12 " " '' cord-010119-t1x9gknd 8797 13 is be VBZ cord-010119-t1x9gknd 8797 14 recommended recommend VBN cord-010119-t1x9gknd 8797 15 to to TO cord-010119-t1x9gknd 8797 16 capture capture VB cord-010119-t1x9gknd 8797 17 otherwise otherwise RB cord-010119-t1x9gknd 8797 18 undiagnosed undiagnosed JJ cord-010119-t1x9gknd 8797 19 cases case NNS cord-010119-t1x9gknd 8797 20 where where WRB cord-010119-t1x9gknd 8797 21 TA ta NN cord-010119-t1x9gknd 8797 22 - - HYPH cord-010119-t1x9gknd 8797 23 passenger passenger NN cord-010119-t1x9gknd 8797 24 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 8797 25 form form VBP cord-010119-t1x9gknd 8797 26 blood blood NN cord-010119-t1x9gknd 8797 27 group group NN cord-010119-t1x9gknd 8797 28 antibodies antibody NNS cord-010119-t1x9gknd 8797 29 in in IN cord-010119-t1x9gknd 8797 30 the the DT cord-010119-t1x9gknd 8797 31 recipient recipient NN cord-010119-t1x9gknd 8797 32 , , , cord-010119-t1x9gknd 8797 33 but but CC cord-010119-t1x9gknd 8797 34 hemolysis hemolysis NN cord-010119-t1x9gknd 8797 35 does do VBZ cord-010119-t1x9gknd 8797 36 not not RB cord-010119-t1x9gknd 8797 37 occur occur VB cord-010119-t1x9gknd 8797 38 , , , cord-010119-t1x9gknd 8797 39 as as IN cord-010119-t1x9gknd 8797 40 in in IN cord-010119-t1x9gknd 8797 41 our -PRON- PRP$ cord-010119-t1x9gknd 8797 42 aforementioned aforementioned JJ cord-010119-t1x9gknd 8797 43 case case NN cord-010119-t1x9gknd 8797 44 . . . cord-010119-t1x9gknd 8798 1 To to TO cord-010119-t1x9gknd 8798 2 ensure ensure VB cord-010119-t1x9gknd 8798 3 including include VBG cord-010119-t1x9gknd 8798 4 the the DT cord-010119-t1x9gknd 8798 5 full full JJ cord-010119-t1x9gknd 8798 6 scope scope NN cord-010119-t1x9gknd 8798 7 of of IN cord-010119-t1x9gknd 8798 8 TA TA NNP cord-010119-t1x9gknd 8798 9 - - HYPH cord-010119-t1x9gknd 8798 10 PLS PLS NNP cord-010119-t1x9gknd 8798 11 , , , cord-010119-t1x9gknd 8798 12 an an DT cord-010119-t1x9gknd 8798 13 antibody antibody NN cord-010119-t1x9gknd 8798 14 screen screen NN cord-010119-t1x9gknd 8798 15 should should MD cord-010119-t1x9gknd 8798 16 be be VB cord-010119-t1x9gknd 8798 17 performed perform VBN cord-010119-t1x9gknd 8798 18 routinely routinely RB cord-010119-t1x9gknd 8798 19 one one CD cord-010119-t1x9gknd 8798 20 week week NN cord-010119-t1x9gknd 8798 21 after after IN cord-010119-t1x9gknd 8798 22 transplant transplant NN cord-010119-t1x9gknd 8798 23 and and CC cord-010119-t1x9gknd 8798 24 repeated repeat VBD cord-010119-t1x9gknd 8798 25 as as IN cord-010119-t1x9gknd 8798 26 clinically clinically RB cord-010119-t1x9gknd 8798 27 indicated indicate VBN cord-010119-t1x9gknd 8798 28 . . . cord-010119-t1x9gknd 8799 1 Occult occult JJ cord-010119-t1x9gknd 8799 2 Hemolytic hemolytic JJ cord-010119-t1x9gknd 8799 3 Anemia anemia NN cord-010119-t1x9gknd 8800 1 Due due IN cord-010119-t1x9gknd 8800 2 to to IN cord-010119-t1x9gknd 8800 3 Anti Anti NNP cord-010119-t1x9gknd 8800 4 - - NNP cord-010119-t1x9gknd 8800 5 Mur Mur NNP cord-010119-t1x9gknd 8800 6 in in IN cord-010119-t1x9gknd 8800 7 a a DT cord-010119-t1x9gknd 8800 8 Patient patient NN cord-010119-t1x9gknd 8800 9 Receiving receive VBG cord-010119-t1x9gknd 8800 10 Blood blood NN cord-010119-t1x9gknd 8800 11 from from IN cord-010119-t1x9gknd 8800 12 a a DT cord-010119-t1x9gknd 8800 13 Region region NN cord-010119-t1x9gknd 8800 14 with with IN cord-010119-t1x9gknd 8800 15 a a DT cord-010119-t1x9gknd 8800 16 Prominent Prominent NNP cord-010119-t1x9gknd 8800 17 Asian asian JJ cord-010119-t1x9gknd 8800 18 Donor Donor NNP cord-010119-t1x9gknd 8800 19 Population Population NNP cord-010119-t1x9gknd 8800 20 Jean Jean NNP cord-010119-t1x9gknd 8800 21 Oak Oak NNP cord-010119-t1x9gknd 8801 1 * * NFP cord-010119-t1x9gknd 8801 2 1 1 CD cord-010119-t1x9gknd 8801 3 , , , cord-010119-t1x9gknd 8801 4 Rosario Rosario NNP cord-010119-t1x9gknd 8801 5 Mallari Mallari NNP cord-010119-t1x9gknd 8801 6 2 2 CD cord-010119-t1x9gknd 8801 7 , , , cord-010119-t1x9gknd 8801 8 Marc Marc NNP cord-010119-t1x9gknd 8801 9 de de NNP cord-010119-t1x9gknd 8801 10 Asis Asis NNP cord-010119-t1x9gknd 8801 11 2 2 CD cord-010119-t1x9gknd 8801 12 , , , cord-010119-t1x9gknd 8801 13 Elaine Elaine NNP cord-010119-t1x9gknd 8801 14 Shu Shu NNP cord-010119-t1x9gknd 8801 15 3 3 CD cord-010119-t1x9gknd 8801 16 , , , cord-010119-t1x9gknd 8801 17 Jonathan Jonathan NNP cord-010119-t1x9gknd 8801 18 Hughes Hughes NNP cord-010119-t1x9gknd 8801 19 4 4 CD cord-010119-t1x9gknd 8801 20 and and CC cord-010119-t1x9gknd 8801 21 Tho Tho NNP cord-010119-t1x9gknd 8801 22 Pham Pham NNP cord-010119-t1x9gknd 8801 23 1,3 1,3 CD cord-010119-t1x9gknd 8801 24 . . . cord-010119-t1x9gknd 8802 1 1 1 CD cord-010119-t1x9gknd 8802 2 Stanford Stanford NNP cord-010119-t1x9gknd 8802 3 University University NNP cord-010119-t1x9gknd 8802 4 , , , cord-010119-t1x9gknd 8802 5 2 2 CD cord-010119-t1x9gknd 8802 6 Stanford Stanford NNP cord-010119-t1x9gknd 8802 7 Health Health NNP cord-010119-t1x9gknd 8802 8 Care Care NNP cord-010119-t1x9gknd 8802 9 , , , cord-010119-t1x9gknd 8802 10 3 3 CD cord-010119-t1x9gknd 8802 11 Stanford Stanford NNP cord-010119-t1x9gknd 8802 12 Blood Blood NNP cord-010119-t1x9gknd 8802 13 Center Center NNP cord-010119-t1x9gknd 8802 14 , , , cord-010119-t1x9gknd 8802 15 4 4 CD cord-010119-t1x9gknd 8802 16 BloodSource BloodSource NNP cord-010119-t1x9gknd 8802 17 Background Background NNP cord-010119-t1x9gknd 8802 18 / / SYM cord-010119-t1x9gknd 8802 19 Case Case NNP cord-010119-t1x9gknd 8802 20 Studies Studies NNPS cord-010119-t1x9gknd 8802 21 : : : cord-010119-t1x9gknd 8803 1 Mur Mur NNP cord-010119-t1x9gknd 8803 2 antigen antigen NN cord-010119-t1x9gknd 8803 3 is be VBZ cord-010119-t1x9gknd 8803 4 present present JJ cord-010119-t1x9gknd 8803 5 in in IN cord-010119-t1x9gknd 8803 6 7 7 CD cord-010119-t1x9gknd 8803 7 - - SYM cord-010119-t1x9gknd 8803 8 10 10 CD cord-010119-t1x9gknd 8803 9 % % NN cord-010119-t1x9gknd 8803 10 of of IN cord-010119-t1x9gknd 8803 11 individuals individual NNS cord-010119-t1x9gknd 8803 12 in in IN cord-010119-t1x9gknd 8803 13 Southeast Southeast NNP cord-010119-t1x9gknd 8803 14 Asia Asia NNP cord-010119-t1x9gknd 8803 15 , , , cord-010119-t1x9gknd 8803 16 Taiwan Taiwan NNP cord-010119-t1x9gknd 8803 17 , , , cord-010119-t1x9gknd 8803 18 and and CC cord-010119-t1x9gknd 8803 19 parts part NNS cord-010119-t1x9gknd 8803 20 of of IN cord-010119-t1x9gknd 8803 21 southeastern southeastern JJ cord-010119-t1x9gknd 8803 22 China China NNP cord-010119-t1x9gknd 8803 23 , , , cord-010119-t1x9gknd 8803 24 but but CC cord-010119-t1x9gknd 8803 25 is be VBZ cord-010119-t1x9gknd 8803 26 rare rare JJ cord-010119-t1x9gknd 8803 27 elsewhere elsewhere RB cord-010119-t1x9gknd 8803 28 . . . cord-010119-t1x9gknd 8804 1 Antibodies antibody NNS cord-010119-t1x9gknd 8804 2 against against IN cord-010119-t1x9gknd 8804 3 Mur Mur NNP cord-010119-t1x9gknd 8804 4 antigens antigen NNS cord-010119-t1x9gknd 8804 5 are be VBP cord-010119-t1x9gknd 8804 6 clinically clinically RB cord-010119-t1x9gknd 8804 7 significant significant JJ cord-010119-t1x9gknd 8804 8 , , , cord-010119-t1x9gknd 8804 9 hence hence RB cord-010119-t1x9gknd 8804 10 many many JJ cord-010119-t1x9gknd 8804 11 countries country NNS cord-010119-t1x9gknd 8804 12 in in IN cord-010119-t1x9gknd 8804 13 Asia Asia NNP cord-010119-t1x9gknd 8804 14 routinely routinely RB cord-010119-t1x9gknd 8804 15 screen screen VBP cord-010119-t1x9gknd 8804 16 for for IN cord-010119-t1x9gknd 8804 17 it -PRON- PRP cord-010119-t1x9gknd 8804 18 while while IN cord-010119-t1x9gknd 8804 19 other other JJ cord-010119-t1x9gknd 8804 20 countries country NNS cord-010119-t1x9gknd 8804 21 , , , cord-010119-t1x9gknd 8804 22 including include VBG cord-010119-t1x9gknd 8804 23 the the DT cord-010119-t1x9gknd 8804 24 US US NNP cord-010119-t1x9gknd 8804 25 , , , cord-010119-t1x9gknd 8804 26 does do VBZ cord-010119-t1x9gknd 8804 27 not not RB cord-010119-t1x9gknd 8804 28 include include VB cord-010119-t1x9gknd 8804 29 Mur Mur NNP cord-010119-t1x9gknd 8804 30 in in IN cord-010119-t1x9gknd 8804 31 the the DT cord-010119-t1x9gknd 8804 32 standard standard JJ cord-010119-t1x9gknd 8804 33 screen screen NN cord-010119-t1x9gknd 8804 34 . . . cord-010119-t1x9gknd 8805 1 We -PRON- PRP cord-010119-t1x9gknd 8805 2 describe describe VBP cord-010119-t1x9gknd 8805 3 a a DT cord-010119-t1x9gknd 8805 4 case case NN cord-010119-t1x9gknd 8805 5 of of IN cord-010119-t1x9gknd 8805 6 an an DT cord-010119-t1x9gknd 8805 7 occult occult JJ cord-010119-t1x9gknd 8805 8 anti anti JJ cord-010119-t1x9gknd 8805 9 - - JJ cord-010119-t1x9gknd 8805 10 Mur Mur NNP cord-010119-t1x9gknd 8805 11 antibody antibody NN cord-010119-t1x9gknd 8805 12 causing cause VBG cord-010119-t1x9gknd 8805 13 anemia anemia NN cord-010119-t1x9gknd 8805 14 and and CC cord-010119-t1x9gknd 8805 15 donor donor NN cord-010119-t1x9gknd 8805 16 ethnicity ethnicity NN cord-010119-t1x9gknd 8805 17 distribution distribution NN cord-010119-t1x9gknd 8805 18 in in IN cord-010119-t1x9gknd 8805 19 a a DT cord-010119-t1x9gknd 8805 20 regional regional JJ cord-010119-t1x9gknd 8805 21 blood blood NN cord-010119-t1x9gknd 8805 22 center center NN cord-010119-t1x9gknd 8805 23 with with IN cord-010119-t1x9gknd 8805 24 a a DT cord-010119-t1x9gknd 8805 25 large large JJ cord-010119-t1x9gknd 8805 26 Asian asian JJ cord-010119-t1x9gknd 8805 27 donor donor NN cord-010119-t1x9gknd 8805 28 population population NN cord-010119-t1x9gknd 8805 29 . . . cord-010119-t1x9gknd 8806 1 41 41 CD cord-010119-t1x9gknd 8806 2 year year NN cord-010119-t1x9gknd 8806 3 old old JJ cord-010119-t1x9gknd 8806 4 Hispanic hispanic JJ cord-010119-t1x9gknd 8806 5 male male NN cord-010119-t1x9gknd 8806 6 with with IN cord-010119-t1x9gknd 8806 7 chronic chronic JJ cord-010119-t1x9gknd 8806 8 myelomonocytic myelomonocytic JJ cord-010119-t1x9gknd 8806 9 leukemia leukemia NN cord-010119-t1x9gknd 8806 10 and and CC cord-010119-t1x9gknd 8806 11 plasma plasma NN cord-010119-t1x9gknd 8806 12 cell cell NN cord-010119-t1x9gknd 8806 13 dyscrasia dyscrasia NNP cord-010119-t1x9gknd 8806 14 developed develop VBD cord-010119-t1x9gknd 8806 15 anemia anemia NN cord-010119-t1x9gknd 8806 16 . . . cord-010119-t1x9gknd 8807 1 Initial initial JJ cord-010119-t1x9gknd 8807 2 antibody antibody NN cord-010119-t1x9gknd 8807 3 screen screen NN cord-010119-t1x9gknd 8807 4 and and CC cord-010119-t1x9gknd 8807 5 DAT DAT NNP cord-010119-t1x9gknd 8807 6 were be VBD cord-010119-t1x9gknd 8807 7 negative negative JJ cord-010119-t1x9gknd 8807 8 , , , cord-010119-t1x9gknd 8807 9 and and CC cord-010119-t1x9gknd 8807 10 the the DT cord-010119-t1x9gknd 8807 11 patient patient NN cord-010119-t1x9gknd 8807 12 received receive VBD cord-010119-t1x9gknd 8807 13 1 1 CD cord-010119-t1x9gknd 8807 14 - - SYM cord-010119-t1x9gknd 8807 15 2 2 CD cord-010119-t1x9gknd 8807 16 RBC RBC NNP cord-010119-t1x9gknd 8807 17 units unit NNS cord-010119-t1x9gknd 8807 18 every every DT cord-010119-t1x9gknd 8807 19 1 1 CD cord-010119-t1x9gknd 8807 20 - - SYM cord-010119-t1x9gknd 8807 21 2 2 CD cord-010119-t1x9gknd 8807 22 weeks week NNS cord-010119-t1x9gknd 8807 23 to to TO cord-010119-t1x9gknd 8807 24 maintain maintain VB cord-010119-t1x9gknd 8807 25 a a DT cord-010119-t1x9gknd 8807 26 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8807 27 ( ( -LRB- cord-010119-t1x9gknd 8807 28 Hb Hb NNP cord-010119-t1x9gknd 8807 29 ) ) -RRB- cord-010119-t1x9gknd 8807 30 level level NN cord-010119-t1x9gknd 8807 31 of of IN cord-010119-t1x9gknd 8807 32 8 8 CD cord-010119-t1x9gknd 8808 1 g g NNP cord-010119-t1x9gknd 8808 2 / / SYM cord-010119-t1x9gknd 8808 3 dL. dL. NNP cord-010119-t1x9gknd 8809 1 The the DT cord-010119-t1x9gknd 8809 2 patient patient NN cord-010119-t1x9gknd 8809 3 remained remain VBD cord-010119-t1x9gknd 8809 4 stable stable JJ cord-010119-t1x9gknd 8809 5 for for IN cord-010119-t1x9gknd 8809 6 5 5 CD cord-010119-t1x9gknd 8809 7 months month NNS cord-010119-t1x9gknd 8809 8 when when WRB cord-010119-t1x9gknd 8809 9 his -PRON- PRP$ cord-010119-t1x9gknd 8809 10 Hb Hb NNP cord-010119-t1x9gknd 8809 11 level level NN cord-010119-t1x9gknd 8809 12 acutely acutely RB cord-010119-t1x9gknd 8809 13 dropped drop VBD cord-010119-t1x9gknd 8809 14 to to IN cord-010119-t1x9gknd 8809 15 6.6 6.6 CD cord-010119-t1x9gknd 8809 16 g g NN cord-010119-t1x9gknd 8809 17 / / SYM cord-010119-t1x9gknd 8809 18 dL. dl. NN cord-010119-t1x9gknd 8810 1 The the DT cord-010119-t1x9gknd 8810 2 antibody antibody NN cord-010119-t1x9gknd 8810 3 screen screen NN cord-010119-t1x9gknd 8810 4 remained remain VBD cord-010119-t1x9gknd 8810 5 negative negative JJ cord-010119-t1x9gknd 8810 6 for for IN cord-010119-t1x9gknd 8810 7 an an DT cord-010119-t1x9gknd 8810 8 additional additional JJ cord-010119-t1x9gknd 8810 9 2 2 CD cord-010119-t1x9gknd 8810 10 months month NNS cord-010119-t1x9gknd 8810 11 when when WRB cord-010119-t1x9gknd 8810 12 it -PRON- PRP cord-010119-t1x9gknd 8810 13 became become VBD cord-010119-t1x9gknd 8810 14 positive positive JJ cord-010119-t1x9gknd 8810 15 for for IN cord-010119-t1x9gknd 8810 16 anti anti JJ cord-010119-t1x9gknd 8810 17 - - JJ cord-010119-t1x9gknd 8810 18 Jka jka JJ cord-010119-t1x9gknd 8810 19 and and CC cord-010119-t1x9gknd 8810 20 anti anti JJ cord-010119-t1x9gknd 8810 21 - - NNP cord-010119-t1x9gknd 8810 22 Mur Mur NNP cord-010119-t1x9gknd 8810 23 . . . cord-010119-t1x9gknd 8811 1 Donor donor NN cord-010119-t1x9gknd 8811 2 ethnicity ethnicity NN cord-010119-t1x9gknd 8811 3 data datum NNS cord-010119-t1x9gknd 8811 4 was be VBD cord-010119-t1x9gknd 8811 5 available available JJ cord-010119-t1x9gknd 8811 6 for for IN cord-010119-t1x9gknd 8811 7 30 30 CD cord-010119-t1x9gknd 8811 8 of of IN cord-010119-t1x9gknd 8811 9 the the DT cord-010119-t1x9gknd 8811 10 33 33 CD cord-010119-t1x9gknd 8811 11 RBC RBC NNP cord-010119-t1x9gknd 8811 12 units unit NNS cord-010119-t1x9gknd 8811 13 he -PRON- PRP cord-010119-t1x9gknd 8811 14 received receive VBD cord-010119-t1x9gknd 8811 15 . . . cord-010119-t1x9gknd 8812 1 3 3 CD cord-010119-t1x9gknd 8812 2 units unit NNS cord-010119-t1x9gknd 8812 3 were be VBD cord-010119-t1x9gknd 8812 4 from from IN cord-010119-t1x9gknd 8812 5 an an DT cord-010119-t1x9gknd 8812 6 Asian asian JJ cord-010119-t1x9gknd 8812 7 donor donor NN cord-010119-t1x9gknd 8812 8 , , , cord-010119-t1x9gknd 8812 9 and and CC cord-010119-t1x9gknd 8812 10 a a DT cord-010119-t1x9gknd 8812 11 unit unit NN cord-010119-t1x9gknd 8812 12 transfused transfuse VBD cord-010119-t1x9gknd 8812 13 13 13 CD cord-010119-t1x9gknd 8812 14 days day NNS cord-010119-t1x9gknd 8812 15 prior prior RB cord-010119-t1x9gknd 8812 16 to to IN cord-010119-t1x9gknd 8812 17 the the DT cord-010119-t1x9gknd 8812 18 Hb Hb NNP cord-010119-t1x9gknd 8812 19 drop drop NN cord-010119-t1x9gknd 8812 20 was be VBD cord-010119-t1x9gknd 8812 21 from from IN cord-010119-t1x9gknd 8812 22 a a DT cord-010119-t1x9gknd 8812 23 Caucasian caucasian JJ cord-010119-t1x9gknd 8812 24 / / SYM cord-010119-t1x9gknd 8812 25 Chinese chinese JJ cord-010119-t1x9gknd 8812 26 donor donor NN cord-010119-t1x9gknd 8812 27 . . . cord-010119-t1x9gknd 8813 1 Study Study NNP cord-010119-t1x9gknd 8813 2 Design Design NNP cord-010119-t1x9gknd 8813 3 / / SYM cord-010119-t1x9gknd 8813 4 Method method NN cord-010119-t1x9gknd 8813 5 : : : cord-010119-t1x9gknd 8813 6 We -PRON- PRP cord-010119-t1x9gknd 8813 7 reviewed review VBD cord-010119-t1x9gknd 8813 8 the the DT cord-010119-t1x9gknd 8813 9 ethnicity ethnicity NN cord-010119-t1x9gknd 8813 10 data datum NNS cord-010119-t1x9gknd 8813 11 of of IN cord-010119-t1x9gknd 8813 12 64,495 64,495 CD cord-010119-t1x9gknd 8813 13 donors donor NNS cord-010119-t1x9gknd 8813 14 at at IN cord-010119-t1x9gknd 8813 15 a a DT cord-010119-t1x9gknd 8813 16 hospital hospital NN cord-010119-t1x9gknd 8813 17 - - HYPH cord-010119-t1x9gknd 8813 18 associated associate VBN cord-010119-t1x9gknd 8813 19 blood blood NN cord-010119-t1x9gknd 8813 20 center center NN cord-010119-t1x9gknd 8813 21 located locate VBN cord-010119-t1x9gknd 8813 22 in in IN cord-010119-t1x9gknd 8813 23 a a DT cord-010119-t1x9gknd 8813 24 region region NN cord-010119-t1x9gknd 8813 25 where where WRB cord-010119-t1x9gknd 8813 26 Asians Asians NNPS cord-010119-t1x9gknd 8813 27 comprise comprise VBP cord-010119-t1x9gknd 8813 28 approximately approximately RB cord-010119-t1x9gknd 8813 29 30 30 CD cord-010119-t1x9gknd 8813 30 % % NN cord-010119-t1x9gknd 8813 31 of of IN cord-010119-t1x9gknd 8813 32 the the DT cord-010119-t1x9gknd 8813 33 population population NN cord-010119-t1x9gknd 8813 34 . . . cord-010119-t1x9gknd 8814 1 Results result NNS cord-010119-t1x9gknd 8815 1 /Finding /finde VBG cord-010119-t1x9gknd 8815 2 : : : cord-010119-t1x9gknd 8815 3 6.6 6.6 CD cord-010119-t1x9gknd 8815 4 % % NN cord-010119-t1x9gknd 8815 5 of of IN cord-010119-t1x9gknd 8815 6 donors donor NNS cord-010119-t1x9gknd 8815 7 identified identify VBN cord-010119-t1x9gknd 8815 8 as as IN cord-010119-t1x9gknd 8815 9 Chinese chinese JJ cord-010119-t1x9gknd 8815 10 , , , cord-010119-t1x9gknd 8815 11 Vietnamese vietnamese JJ cord-010119-t1x9gknd 8815 12 , , , cord-010119-t1x9gknd 8815 13 Filipino Filipino NNP cord-010119-t1x9gknd 8815 14 , , , cord-010119-t1x9gknd 8815 15 or or CC cord-010119-t1x9gknd 8815 16 other other JJ cord-010119-t1x9gknd 8815 17 Southeastern Southeastern NNP cord-010119-t1x9gknd 8815 18 Asian Asian NNP cord-010119-t1x9gknd 8815 19 . . . cord-010119-t1x9gknd 8816 1 These these DT cord-010119-t1x9gknd 8816 2 donors donor NNS cord-010119-t1x9gknd 8816 3 account account VBP cord-010119-t1x9gknd 8816 4 for for IN cord-010119-t1x9gknd 8816 5 5245 5245 CD cord-010119-t1x9gknd 8816 6 of of IN cord-010119-t1x9gknd 8816 7 37933 37933 CD cord-010119-t1x9gknd 8816 8 ( ( -LRB- cord-010119-t1x9gknd 8816 9 13.8 13.8 CD cord-010119-t1x9gknd 8816 10 % % NN cord-010119-t1x9gknd 8816 11 ) ) -RRB- cord-010119-t1x9gknd 8817 1 RBC RBC NNP cord-010119-t1x9gknd 8817 2 collections collection NNS cord-010119-t1x9gknd 8817 3 . . . cord-010119-t1x9gknd 8818 1 Conclusion conclusion NN cord-010119-t1x9gknd 8818 2 : : : cord-010119-t1x9gknd 8818 3 Identification identification NN cord-010119-t1x9gknd 8818 4 of of IN cord-010119-t1x9gknd 8818 5 anti anti JJ cord-010119-t1x9gknd 8818 6 - - NNP cord-010119-t1x9gknd 8818 7 Mur Mur NNP cord-010119-t1x9gknd 8818 8 in in IN cord-010119-t1x9gknd 8818 9 this this DT cord-010119-t1x9gknd 8818 10 patient patient NN cord-010119-t1x9gknd 8818 11 was be VBD cord-010119-t1x9gknd 8818 12 triggered trigger VBN cord-010119-t1x9gknd 8818 13 by by IN cord-010119-t1x9gknd 8818 14 the the DT cord-010119-t1x9gknd 8818 15 presence presence NN cord-010119-t1x9gknd 8818 16 of of IN cord-010119-t1x9gknd 8818 17 a a DT cord-010119-t1x9gknd 8818 18 concurrent concurrent JJ cord-010119-t1x9gknd 8818 19 anti anti JJ cord-010119-t1x9gknd 8818 20 - - JJ cord-010119-t1x9gknd 8818 21 Jka jka JJ cord-010119-t1x9gknd 8818 22 alloantibody alloantibody NN cord-010119-t1x9gknd 8818 23 . . . cord-010119-t1x9gknd 8819 1 Since since IN cord-010119-t1x9gknd 8819 2 over over IN cord-010119-t1x9gknd 8819 3 10 10 CD cord-010119-t1x9gknd 8819 4 % % NN cord-010119-t1x9gknd 8819 5 of of IN cord-010119-t1x9gknd 8819 6 the the DT cord-010119-t1x9gknd 8819 7 RBC RBC NNP cord-010119-t1x9gknd 8819 8 supply supply NN cord-010119-t1x9gknd 8819 9 in in IN cord-010119-t1x9gknd 8819 10 the the DT cord-010119-t1x9gknd 8819 11 local local JJ cord-010119-t1x9gknd 8819 12 blood blood NN cord-010119-t1x9gknd 8819 13 center center NN cord-010119-t1x9gknd 8819 14 was be VBD cord-010119-t1x9gknd 8819 15 collected collect VBN cord-010119-t1x9gknd 8819 16 from from IN cord-010119-t1x9gknd 8819 17 Chinese chinese JJ cord-010119-t1x9gknd 8819 18 or or CC cord-010119-t1x9gknd 8819 19 Southeast southeast JJ cord-010119-t1x9gknd 8819 20 Asian asian JJ cord-010119-t1x9gknd 8819 21 donors donor NNS cord-010119-t1x9gknd 8819 22 , , , cord-010119-t1x9gknd 8819 23 chronically chronically RB cord-010119-t1x9gknd 8819 24 transfused transfuse VBN cord-010119-t1x9gknd 8819 25 patients patient NNS cord-010119-t1x9gknd 8819 26 are be VBP cord-010119-t1x9gknd 8819 27 at at IN cord-010119-t1x9gknd 8819 28 risk risk NN cord-010119-t1x9gknd 8819 29 of of IN cord-010119-t1x9gknd 8819 30 developing develop VBG cord-010119-t1x9gknd 8819 31 anti anti JJ cord-010119-t1x9gknd 8819 32 - - JJ cord-010119-t1x9gknd 8819 33 Mur Mur NNP cord-010119-t1x9gknd 8819 34 - - HYPH cord-010119-t1x9gknd 8819 35 mediated mediate VBN cord-010119-t1x9gknd 8819 36 hemolysis hemolysis NN cord-010119-t1x9gknd 8819 37 that that WDT cord-010119-t1x9gknd 8819 38 could could MD cord-010119-t1x9gknd 8819 39 be be VB cord-010119-t1x9gknd 8819 40 missed miss VBN cord-010119-t1x9gknd 8819 41 on on IN cord-010119-t1x9gknd 8819 42 a a DT cord-010119-t1x9gknd 8819 43 standard standard JJ cord-010119-t1x9gknd 8819 44 screen screen NN cord-010119-t1x9gknd 8819 45 . . . cord-010119-t1x9gknd 8820 1 This this DT cord-010119-t1x9gknd 8820 2 finding finding NN cord-010119-t1x9gknd 8820 3 raises raise VBZ cord-010119-t1x9gknd 8820 4 a a DT cord-010119-t1x9gknd 8820 5 possible possible JJ cord-010119-t1x9gknd 8820 6 need need NN cord-010119-t1x9gknd 8820 7 for for IN cord-010119-t1x9gknd 8820 8 blood blood NN cord-010119-t1x9gknd 8820 9 banks bank NNS cord-010119-t1x9gknd 8820 10 located locate VBN cord-010119-t1x9gknd 8820 11 in in IN cord-010119-t1x9gknd 8820 12 regions region NNS cord-010119-t1x9gknd 8820 13 with with IN cord-010119-t1x9gknd 8820 14 a a DT cord-010119-t1x9gknd 8820 15 prominent prominent JJ cord-010119-t1x9gknd 8820 16 Asian asian JJ cord-010119-t1x9gknd 8820 17 population population NN cord-010119-t1x9gknd 8820 18 to to TO cord-010119-t1x9gknd 8820 19 implement implement VB cord-010119-t1x9gknd 8820 20 screening screening NN cord-010119-t1x9gknd 8820 21 for for IN cord-010119-t1x9gknd 8820 22 anti anti JJ cord-010119-t1x9gknd 8820 23 - - JJ cord-010119-t1x9gknd 8820 24 Mur Mur NNP cord-010119-t1x9gknd 8820 25 . . . cord-010119-t1x9gknd 8821 1 Brian Brian NNP cord-010119-t1x9gknd 8821 2 Adkins Adkins NNP cord-010119-t1x9gknd 8821 3 * * NFP cord-010119-t1x9gknd 8821 4 1 1 CD cord-010119-t1x9gknd 8821 5 , , , cord-010119-t1x9gknd 8821 6 Princess Princess NNP cord-010119-t1x9gknd 8821 7 Maynie Maynie NNP cord-010119-t1x9gknd 8821 8 1 1 CD cord-010119-t1x9gknd 8821 9 , , , cord-010119-t1x9gknd 8821 10 Carol Carol NNP cord-010119-t1x9gknd 8821 11 Chandler Chandler NNP cord-010119-t1x9gknd 8821 12 1 1 CD cord-010119-t1x9gknd 8821 13 , , , cord-010119-t1x9gknd 8821 14 Shelia Shelia NNP cord-010119-t1x9gknd 8821 15 Garret Garret NNP cord-010119-t1x9gknd 8821 16 1 1 CD cord-010119-t1x9gknd 8821 17 and and CC cord-010119-t1x9gknd 8821 18 Pampee Pampee NNP cord-010119-t1x9gknd 8821 19 Young Young NNP cord-010119-t1x9gknd 8821 20 2 2 CD cord-010119-t1x9gknd 8821 21 . . . cord-010119-t1x9gknd 8822 1 1 1 CD cord-010119-t1x9gknd 8822 2 Vanderbilt Vanderbilt NNP cord-010119-t1x9gknd 8822 3 , , , cord-010119-t1x9gknd 8822 4 2 2 CD cord-010119-t1x9gknd 8822 5 Vanderbilt Vanderbilt NNP cord-010119-t1x9gknd 8822 6 University University NNP cord-010119-t1x9gknd 8822 7 Medical Medical NNP cord-010119-t1x9gknd 8822 8 Center Center NNP cord-010119-t1x9gknd 8822 9 , , , cord-010119-t1x9gknd 8822 10 Department Department NNP cord-010119-t1x9gknd 8822 11 of of IN cord-010119-t1x9gknd 8822 12 Pathology Pathology NNP cord-010119-t1x9gknd 8822 13 , , , cord-010119-t1x9gknd 8822 14 Microbiology Microbiology NNP cord-010119-t1x9gknd 8822 15 and and CC cord-010119-t1x9gknd 8822 16 Immunology Immunology NNP cord-010119-t1x9gknd 8822 17 Background Background NNP cord-010119-t1x9gknd 8822 18 / / SYM cord-010119-t1x9gknd 8822 19 Case Case NNP cord-010119-t1x9gknd 8822 20 Studies Studies NNPS cord-010119-t1x9gknd 8822 21 : : : cord-010119-t1x9gknd 8822 22 Antibody antibody NN cord-010119-t1x9gknd 8822 23 titration titration NN cord-010119-t1x9gknd 8822 24 is be VBZ cord-010119-t1x9gknd 8822 25 a a DT cord-010119-t1x9gknd 8822 26 testing testing NN cord-010119-t1x9gknd 8822 27 modality modality NN cord-010119-t1x9gknd 8822 28 vital vital JJ cord-010119-t1x9gknd 8822 29 to to IN cord-010119-t1x9gknd 8822 30 both both DT cord-010119-t1x9gknd 8822 31 obstetric obstetric JJ cord-010119-t1x9gknd 8822 32 and and CC cord-010119-t1x9gknd 8822 33 transplant transplant NN cord-010119-t1x9gknd 8822 34 services service NNS cord-010119-t1x9gknd 8822 35 . . . cord-010119-t1x9gknd 8823 1 Manual manual JJ cord-010119-t1x9gknd 8823 2 direct direct JJ cord-010119-t1x9gknd 8823 3 tube tube NN cord-010119-t1x9gknd 8823 4 testing testing NN cord-010119-t1x9gknd 8823 5 is be VBZ cord-010119-t1x9gknd 8823 6 associated associate VBN cord-010119-t1x9gknd 8823 7 with with IN cord-010119-t1x9gknd 8823 8 variability variability NN cord-010119-t1x9gknd 8823 9 in in IN cord-010119-t1x9gknd 8823 10 results result NNS cord-010119-t1x9gknd 8823 11 ( ( -LRB- cord-010119-t1x9gknd 8823 12 poor poor JJ cord-010119-t1x9gknd 8823 13 reproducibility reproducibility NN cord-010119-t1x9gknd 8823 14 / / SYM cord-010119-t1x9gknd 8823 15 precision precision NN cord-010119-t1x9gknd 8823 16 ) ) -RRB- cord-010119-t1x9gknd 8823 17 and and CC cord-010119-t1x9gknd 8823 18 is be VBZ cord-010119-t1x9gknd 8823 19 also also RB cord-010119-t1x9gknd 8823 20 time time NN cord-010119-t1x9gknd 8823 21 and and CC cord-010119-t1x9gknd 8823 22 resource resource NN cord-010119-t1x9gknd 8823 23 intensive intensive JJ cord-010119-t1x9gknd 8823 24 . . . cord-010119-t1x9gknd 8824 1 In in IN cord-010119-t1x9gknd 8824 2 fact fact NN cord-010119-t1x9gknd 8824 3 , , , cord-010119-t1x9gknd 8824 4 studies study NNS cord-010119-t1x9gknd 8824 5 have have VBP cord-010119-t1x9gknd 8824 6 shown show VBN cord-010119-t1x9gknd 8824 7 a a DT cord-010119-t1x9gknd 8824 8 three three CD cord-010119-t1x9gknd 8824 9 - - HYPH cord-010119-t1x9gknd 8824 10 to to IN cord-010119-t1x9gknd 8824 11 eightfold eightfold VB cord-010119-t1x9gknd 8824 12 inter inter JJ cord-010119-t1x9gknd 8824 13 - - JJ cord-010119-t1x9gknd 8824 14 institutional institutional JJ cord-010119-t1x9gknd 8824 15 difference difference NN cord-010119-t1x9gknd 8824 16 between between IN cord-010119-t1x9gknd 8824 17 the the DT cord-010119-t1x9gknd 8824 18 antibody antibody NN cord-010119-t1x9gknd 8824 19 titers titer NNS cord-010119-t1x9gknd 8824 20 from from IN cord-010119-t1x9gknd 8824 21 the the DT cord-010119-t1x9gknd 8824 22 same same JJ cord-010119-t1x9gknd 8824 23 samples sample NNS cord-010119-t1x9gknd 8824 24 using use VBG cord-010119-t1x9gknd 8824 25 manual manual JJ cord-010119-t1x9gknd 8824 26 tube tube NN cord-010119-t1x9gknd 8824 27 method method NN cord-010119-t1x9gknd 8824 28 . . . cord-010119-t1x9gknd 8825 1 The the DT cord-010119-t1x9gknd 8825 2 OrthoVision OrthoVision NNP cord-010119-t1x9gknd 8825 3 automated automate VBN cord-010119-t1x9gknd 8825 4 analyzers analyzer NNS cord-010119-t1x9gknd 8825 5 offers offer VBZ cord-010119-t1x9gknd 8825 6 automated automate VBN cord-010119-t1x9gknd 8825 7 titering titering NN cord-010119-t1x9gknd 8825 8 of of IN cord-010119-t1x9gknd 8825 9 patient patient NN cord-010119-t1x9gknd 8825 10 plasma plasma NN cord-010119-t1x9gknd 8825 11 using use VBG cord-010119-t1x9gknd 8825 12 gel gel NN cord-010119-t1x9gknd 8825 13 technology technology NN cord-010119-t1x9gknd 8825 14 . . . cord-010119-t1x9gknd 8826 1 Although although IN cord-010119-t1x9gknd 8826 2 there there EX cord-010119-t1x9gknd 8826 3 is be VBZ cord-010119-t1x9gknd 8826 4 intense intense JJ cord-010119-t1x9gknd 8826 5 interest interest NN cord-010119-t1x9gknd 8826 6 in in IN cord-010119-t1x9gknd 8826 7 adopting adopt VBG cord-010119-t1x9gknd 8826 8 automated automate VBN cord-010119-t1x9gknd 8826 9 testing testing NN cord-010119-t1x9gknd 8826 10 technology technology NN cord-010119-t1x9gknd 8826 11 for for IN cord-010119-t1x9gknd 8826 12 titering titering NN cord-010119-t1x9gknd 8826 13 , , , cord-010119-t1x9gknd 8826 14 it -PRON- PRP cord-010119-t1x9gknd 8826 15 is be VBZ cord-010119-t1x9gknd 8826 16 well well RB cord-010119-t1x9gknd 8826 17 - - HYPH cord-010119-t1x9gknd 8826 18 appreciated appreciate VBN cord-010119-t1x9gknd 8826 19 that that IN cord-010119-t1x9gknd 8826 20 titers titer NNS cord-010119-t1x9gknd 8826 21 obtained obtain VBN cord-010119-t1x9gknd 8826 22 in in IN cord-010119-t1x9gknd 8826 23 manual manual JJ cord-010119-t1x9gknd 8826 24 gel gel NN cord-010119-t1x9gknd 8826 25 testing testing NN cord-010119-t1x9gknd 8826 26 are be VBP cord-010119-t1x9gknd 8826 27 much much RB cord-010119-t1x9gknd 8826 28 higher high JJR cord-010119-t1x9gknd 8826 29 than than IN cord-010119-t1x9gknd 8826 30 those those DT cord-010119-t1x9gknd 8826 31 obtained obtain VBN cord-010119-t1x9gknd 8826 32 by by IN cord-010119-t1x9gknd 8826 33 manual manual JJ cord-010119-t1x9gknd 8826 34 / / SYM cord-010119-t1x9gknd 8826 35 direct direct JJ cord-010119-t1x9gknd 8826 36 tube tube NN cord-010119-t1x9gknd 8826 37 testing testing NN cord-010119-t1x9gknd 8826 38 . . . cord-010119-t1x9gknd 8827 1 The the DT cord-010119-t1x9gknd 8827 2 higher high JJR cord-010119-t1x9gknd 8827 3 titer titer NN cord-010119-t1x9gknd 8827 4 results result NNS cord-010119-t1x9gknd 8827 5 lack lack VBP cord-010119-t1x9gknd 8827 6 clinical clinical JJ cord-010119-t1x9gknd 8827 7 fetal fetal JJ cord-010119-t1x9gknd 8827 8 anemia anemia NN cord-010119-t1x9gknd 8827 9 and and CC cord-010119-t1x9gknd 8827 10 outcome outcome NN cord-010119-t1x9gknd 8827 11 correlations correlation NNS cord-010119-t1x9gknd 8827 12 , , , cord-010119-t1x9gknd 8827 13 which which WDT cord-010119-t1x9gknd 8827 14 is be VBZ cord-010119-t1x9gknd 8827 15 a a DT cord-010119-t1x9gknd 8827 16 barrier barrier NN cord-010119-t1x9gknd 8827 17 to to IN cord-010119-t1x9gknd 8827 18 their -PRON- PRP$ cord-010119-t1x9gknd 8827 19 implementation implementation NN cord-010119-t1x9gknd 8827 20 . . . cord-010119-t1x9gknd 8828 1 Moreover moreover RB cord-010119-t1x9gknd 8828 2 , , , cord-010119-t1x9gknd 8828 3 despite despite IN cord-010119-t1x9gknd 8828 4 the the DT cord-010119-t1x9gknd 8828 5 increased increase VBN cord-010119-t1x9gknd 8828 6 sensitivity sensitivity NN cord-010119-t1x9gknd 8828 7 of of IN cord-010119-t1x9gknd 8828 8 gel gel NN cord-010119-t1x9gknd 8828 9 testing testing NN cord-010119-t1x9gknd 8828 10 , , , cord-010119-t1x9gknd 8828 11 prior prior JJ cord-010119-t1x9gknd 8828 12 studies study NNS cord-010119-t1x9gknd 8828 13 have have VBP cord-010119-t1x9gknd 8828 14 found find VBN cord-010119-t1x9gknd 8828 15 variable variable JJ cord-010119-t1x9gknd 8828 16 results result NNS cord-010119-t1x9gknd 8828 17 with with IN cord-010119-t1x9gknd 8828 18 regard regard NN cord-010119-t1x9gknd 8828 19 to to IN cord-010119-t1x9gknd 8828 20 reproducibility reproducibility NN cord-010119-t1x9gknd 8828 21 and and CC cord-010119-t1x9gknd 8828 22 precision precision NN cord-010119-t1x9gknd 8828 23 . . . cord-010119-t1x9gknd 8829 1 [ [ -LRB- cord-010119-t1x9gknd 8829 2 3 3 CD cord-010119-t1x9gknd 8829 3 ] ] -RRB- cord-010119-t1x9gknd 8829 4 [ [ -LRB- cord-010119-t1x9gknd 8829 5 4 4 CD cord-010119-t1x9gknd 8829 6 ] ] -RRB- cord-010119-t1x9gknd 8830 1 [ [ -LRB- cord-010119-t1x9gknd 8830 2 5 5 LS cord-010119-t1x9gknd 8830 3 ] ] -RRB- cord-010119-t1x9gknd 8830 4 There there EX cord-010119-t1x9gknd 8830 5 is be VBZ cord-010119-t1x9gknd 8830 6 minimal minimal JJ cord-010119-t1x9gknd 8830 7 information information NN cord-010119-t1x9gknd 8830 8 on on IN cord-010119-t1x9gknd 8830 9 the the DT cord-010119-t1x9gknd 8830 10 comparisons comparison NNS cord-010119-t1x9gknd 8830 11 of of IN cord-010119-t1x9gknd 8830 12 tube tube NN cord-010119-t1x9gknd 8830 13 titers titer NNS cord-010119-t1x9gknd 8830 14 to to IN cord-010119-t1x9gknd 8830 15 OrthoVIsion OrthoVIsion NNP cord-010119-t1x9gknd 8830 16 automated automate VBN cord-010119-t1x9gknd 8830 17 titers titer NNS cord-010119-t1x9gknd 8830 18 or or CC cord-010119-t1x9gknd 8830 19 assessment assessment NN cord-010119-t1x9gknd 8830 20 of of IN cord-010119-t1x9gknd 8830 21 the the DT cord-010119-t1x9gknd 8830 22 reproducibility reproducibility NN cord-010119-t1x9gknd 8830 23 of of IN cord-010119-t1x9gknd 8830 24 this this DT cord-010119-t1x9gknd 8830 25 automated automate VBN cord-010119-t1x9gknd 8830 26 method method NN cord-010119-t1x9gknd 8830 27 . . . cord-010119-t1x9gknd 8831 1 Study Study NNP cord-010119-t1x9gknd 8831 2 Design Design NNP cord-010119-t1x9gknd 8831 3 / / SYM cord-010119-t1x9gknd 8831 4 Method method NN cord-010119-t1x9gknd 8831 5 : : : cord-010119-t1x9gknd 8832 1 Rh Rh NNP cord-010119-t1x9gknd 8832 2 and and CC cord-010119-t1x9gknd 8832 3 non non NNP cord-010119-t1x9gknd 8832 4 Rh Rh NNP cord-010119-t1x9gknd 8832 5 minor minor JJ cord-010119-t1x9gknd 8832 6 RBC RBC NNP cord-010119-t1x9gknd 8832 7 antibody antibody NN cord-010119-t1x9gknd 8832 8 titrations titration NNS cord-010119-t1x9gknd 8832 9 were be VBD cord-010119-t1x9gknd 8832 10 performed perform VBN cord-010119-t1x9gknd 8832 11 by by IN cord-010119-t1x9gknd 8832 12 manual manual JJ cord-010119-t1x9gknd 8832 13 direct direct JJ cord-010119-t1x9gknd 8832 14 tube tube NN cord-010119-t1x9gknd 8832 15 method method NN cord-010119-t1x9gknd 8832 16 on on IN cord-010119-t1x9gknd 8832 17 clinical clinical JJ cord-010119-t1x9gknd 8832 18 samples sample NNS cord-010119-t1x9gknd 8832 19 and and CC cord-010119-t1x9gknd 8832 20 the the DT cord-010119-t1x9gknd 8832 21 same same JJ cord-010119-t1x9gknd 8832 22 samples sample NNS cord-010119-t1x9gknd 8832 23 were be VBD cord-010119-t1x9gknd 8832 24 analyzed analyze VBN cord-010119-t1x9gknd 8832 25 on on IN cord-010119-t1x9gknd 8832 26 three three CD cord-010119-t1x9gknd 8832 27 different different JJ cord-010119-t1x9gknd 8832 28 ORTHO ORTHO NNP cord-010119-t1x9gknd 8832 29 VISION vision NN cord-010119-t1x9gknd 8832 30 analyzers analyzer NNS cord-010119-t1x9gknd 8832 31 to to TO cord-010119-t1x9gknd 8832 32 assess assess VB cord-010119-t1x9gknd 8832 33 precision precision NN cord-010119-t1x9gknd 8832 34 and and CC cord-010119-t1x9gknd 8832 35 inter inter JJ cord-010119-t1x9gknd 8832 36 - - JJ cord-010119-t1x9gknd 8832 37 instrument instrument JJ cord-010119-t1x9gknd 8832 38 reproducibility reproducibility NN cord-010119-t1x9gknd 8832 39 . . . cord-010119-t1x9gknd 8833 1 Results/ Results/ . cord-010119-t1x9gknd 8834 1 Finding finding NN cord-010119-t1x9gknd 8834 2 : : : cord-010119-t1x9gknd 8834 3 A a DT cord-010119-t1x9gknd 8834 4 total total NN cord-010119-t1x9gknd 8834 5 of of IN cord-010119-t1x9gknd 8834 6 26 26 CD cord-010119-t1x9gknd 8834 7 samples sample NNS cord-010119-t1x9gknd 8834 8 have have VBP cord-010119-t1x9gknd 8834 9 been be VBN cord-010119-t1x9gknd 8834 10 analyzed analyze VBN cord-010119-t1x9gknd 8834 11 ( ( -LRB- cord-010119-t1x9gknd 8834 12 Table table NN cord-010119-t1x9gknd 8834 13 ) ) -RRB- cord-010119-t1x9gknd 8834 14 , , , cord-010119-t1x9gknd 8834 15 17 17 CD cord-010119-t1x9gknd 8834 16 Rh Rh NNP cord-010119-t1x9gknd 8834 17 and and CC cord-010119-t1x9gknd 8834 18 9 9 CD cord-010119-t1x9gknd 8834 19 non non JJ cord-010119-t1x9gknd 8834 20 - - JJ cord-010119-t1x9gknd 8834 21 Rh Rh NNP cord-010119-t1x9gknd 8834 22 antigens antigen NNS cord-010119-t1x9gknd 8834 23 . . . cord-010119-t1x9gknd 8835 1 Titers titer NNS cord-010119-t1x9gknd 8835 2 via via IN cord-010119-t1x9gknd 8835 3 automated automated JJ cord-010119-t1x9gknd 8835 4 testing testing NN cord-010119-t1x9gknd 8835 5 on on IN cord-010119-t1x9gknd 8835 6 OrthoVision OrthoVision NNP cord-010119-t1x9gknd 8835 7 resulted result VBD cord-010119-t1x9gknd 8835 8 in in IN cord-010119-t1x9gknd 8835 9 a a DT cord-010119-t1x9gknd 8835 10 mean mean JJ cord-010119-t1x9gknd 8835 11 titration titration NN cord-010119-t1x9gknd 8835 12 being be VBG cord-010119-t1x9gknd 8835 13 2.77 2.77 CD cord-010119-t1x9gknd 8836 1 ( ( -LRB- cord-010119-t1x9gknd 8836 2 range range NNP cord-010119-t1x9gknd 8836 3 1 1 CD cord-010119-t1x9gknd 8836 4 - - SYM cord-010119-t1x9gknd 8836 5 7 7 CD cord-010119-t1x9gknd 8836 6 ) ) -RRB- cord-010119-t1x9gknd 8836 7 times time NNS cord-010119-t1x9gknd 8836 8 higher high JJR cord-010119-t1x9gknd 8836 9 . . . cord-010119-t1x9gknd 8837 1 The the DT cord-010119-t1x9gknd 8837 2 average average JJ cord-010119-t1x9gknd 8837 3 fold fold JJ cord-010119-t1x9gknd 8837 4 change change NN cord-010119-t1x9gknd 8837 5 for for IN cord-010119-t1x9gknd 8837 6 RhD RhD NNP cord-010119-t1x9gknd 8837 7 / / SYM cord-010119-t1x9gknd 8837 8 C C NNP cord-010119-t1x9gknd 8837 9 / / SYM cord-010119-t1x9gknd 8837 10 E e NN cord-010119-t1x9gknd 8837 11 antibody antibody NN cord-010119-t1x9gknd 8837 12 titers titer NNS cord-010119-t1x9gknd 8837 13 were be VBD cord-010119-t1x9gknd 8837 14 3.2 3.2 CD cord-010119-t1x9gknd 8837 15 , , , cord-010119-t1x9gknd 8837 16 whereas whereas IN cord-010119-t1x9gknd 8837 17 the the DT cord-010119-t1x9gknd 8837 18 average average JJ cord-010119-t1x9gknd 8837 19 fold fold JJ cord-010119-t1x9gknd 8837 20 change change NN cord-010119-t1x9gknd 8837 21 for for IN cord-010119-t1x9gknd 8837 22 non non JJ cord-010119-t1x9gknd 8837 23 Rh Rh NNP cord-010119-t1x9gknd 8837 24 titers titer NNS cord-010119-t1x9gknd 8837 25 was be VBD cord-010119-t1x9gknd 8837 26 1.03 1.03 CD cord-010119-t1x9gknd 8837 27 ( ( -LRB- cord-010119-t1x9gknd 8837 28 range range NNP cord-010119-t1x9gknd 8837 29 1 1 CD cord-010119-t1x9gknd 8837 30 - - SYM cord-010119-t1x9gknd 8837 31 2 2 CD cord-010119-t1x9gknd 8837 32 ) ) -RRB- cord-010119-t1x9gknd 8837 33 . . . cord-010119-t1x9gknd 8838 1 The the DT cord-010119-t1x9gknd 8838 2 range range NN cord-010119-t1x9gknd 8838 3 for for IN cord-010119-t1x9gknd 8838 4 anti anti FW cord-010119-t1x9gknd 8838 5 D d NN cord-010119-t1x9gknd 8838 6 titers titer NNS cord-010119-t1x9gknd 8838 7 was be VBD cord-010119-t1x9gknd 8838 8 particularly particularly RB cord-010119-t1x9gknd 8838 9 variable variable JJ cord-010119-t1x9gknd 8838 10 , , , cord-010119-t1x9gknd 8838 11 2 2 CD cord-010119-t1x9gknd 8838 12 - - SYM cord-010119-t1x9gknd 8838 13 7 7 CD cord-010119-t1x9gknd 8838 14 , , , cord-010119-t1x9gknd 8838 15 whereas whereas IN cord-010119-t1x9gknd 8838 16 for for IN cord-010119-t1x9gknd 8838 17 C c NN cord-010119-t1x9gknd 8838 18 / / SYM cord-010119-t1x9gknd 8838 19 E E NNP cord-010119-t1x9gknd 8838 20 , , , cord-010119-t1x9gknd 8838 21 it -PRON- PRP cord-010119-t1x9gknd 8838 22 was be VBD cord-010119-t1x9gknd 8838 23 1 1 CD cord-010119-t1x9gknd 8838 24 - - SYM cord-010119-t1x9gknd 8838 25 3 3 CD cord-010119-t1x9gknd 8838 26 . . . cord-010119-t1x9gknd 8839 1 The the DT cord-010119-t1x9gknd 8839 2 overall overall JJ cord-010119-t1x9gknd 8839 3 reproducibility reproducibility NN cord-010119-t1x9gknd 8839 4 / / SYM cord-010119-t1x9gknd 8839 5 precision precision NN cord-010119-t1x9gknd 8839 6 of of IN cord-010119-t1x9gknd 8839 7 the the DT cord-010119-t1x9gknd 8839 8 automated automated JJ cord-010119-t1x9gknd 8839 9 analyzer analyzer NN cord-010119-t1x9gknd 8839 10 was be VBD cord-010119-t1x9gknd 8839 11 $ $ $ cord-010119-t1x9gknd 8839 12 90 90 CD cord-010119-t1x9gknd 8839 13 % % NN cord-010119-t1x9gknd 8839 14 . . . cord-010119-t1x9gknd 8840 1 To to TO cord-010119-t1x9gknd 8840 2 correlate correlate VB cord-010119-t1x9gknd 8840 3 the the DT cord-010119-t1x9gknd 8840 4 178A 178a CD cord-010119-t1x9gknd 8840 5 TRANSFUSION transfusion NN cord-010119-t1x9gknd 8840 6 2017 2017 CD cord-010119-t1x9gknd 8840 7 Vol Vol NNP cord-010119-t1x9gknd 8840 8 . . . cord-010119-t1x9gknd 8841 1 57 57 CD cord-010119-t1x9gknd 8841 2 Supplement Supplement NNP cord-010119-t1x9gknd 8841 3 S3 S3 NNP cord-010119-t1x9gknd 8841 4 increased increase VBD cord-010119-t1x9gknd 8841 5 titers titer NNS cord-010119-t1x9gknd 8841 6 observed observe VBD cord-010119-t1x9gknd 8841 7 with with IN cord-010119-t1x9gknd 8841 8 some some DT cord-010119-t1x9gknd 8841 9 classes class NNS cord-010119-t1x9gknd 8841 10 of of IN cord-010119-t1x9gknd 8841 11 antibodies antibody NNS cord-010119-t1x9gknd 8841 12 , , , cord-010119-t1x9gknd 8841 13 particularly particularly RB cord-010119-t1x9gknd 8841 14 anti anti AFX cord-010119-t1x9gknd 8841 15 D D NNP cord-010119-t1x9gknd 8841 16 , , , cord-010119-t1x9gknd 8841 17 we -PRON- PRP cord-010119-t1x9gknd 8841 18 will will MD cord-010119-t1x9gknd 8841 19 be be VB cord-010119-t1x9gknd 8841 20 performing perform VBG cord-010119-t1x9gknd 8841 21 parallel parallel JJ cord-010119-t1x9gknd 8841 22 testing testing NN cord-010119-t1x9gknd 8841 23 of of IN cord-010119-t1x9gknd 8841 24 obstetric obstetric JJ cord-010119-t1x9gknd 8841 25 samples sample NNS cord-010119-t1x9gknd 8841 26 and and CC cord-010119-t1x9gknd 8841 27 correlating correlate VBG cord-010119-t1x9gknd 8841 28 with with IN cord-010119-t1x9gknd 8841 29 pregnancy pregnancy NN cord-010119-t1x9gknd 8841 30 outcome outcome NN cord-010119-t1x9gknd 8841 31 / / SYM cord-010119-t1x9gknd 8841 32 fetal fetal JJ cord-010119-t1x9gknd 8841 33 testing test VBG cord-010119-t1x9gknd 8841 34 the the DT cord-010119-t1x9gknd 8841 35 obtained obtain VBN cord-010119-t1x9gknd 8841 36 values value NNS cord-010119-t1x9gknd 8841 37 . . . cord-010119-t1x9gknd 8842 1 Conclusion conclusion NN cord-010119-t1x9gknd 8842 2 : : : cord-010119-t1x9gknd 8843 1 Automated automated JJ cord-010119-t1x9gknd 8843 2 titration titration NN cord-010119-t1x9gknd 8843 3 of of IN cord-010119-t1x9gknd 8843 4 antibodies antibody NNS cord-010119-t1x9gknd 8843 5 using use VBG cord-010119-t1x9gknd 8843 6 the the DT cord-010119-t1x9gknd 8843 7 OrthoVision OrthoVision NNP cord-010119-t1x9gknd 8843 8 Analyzers Analyzers NNPS cord-010119-t1x9gknd 8843 9 resulted result VBD cord-010119-t1x9gknd 8843 10 in in IN cord-010119-t1x9gknd 8843 11 highly highly RB cord-010119-t1x9gknd 8843 12 reproducible reproducible JJ cord-010119-t1x9gknd 8843 13 results result NNS cord-010119-t1x9gknd 8843 14 between between IN cord-010119-t1x9gknd 8843 15 different different JJ cord-010119-t1x9gknd 8843 16 instruments instrument NNS cord-010119-t1x9gknd 8843 17 using use VBG cord-010119-t1x9gknd 8843 18 the the DT cord-010119-t1x9gknd 8843 19 same same JJ cord-010119-t1x9gknd 8843 20 sample sample NN cord-010119-t1x9gknd 8843 21 . . . cord-010119-t1x9gknd 8844 1 However however RB cord-010119-t1x9gknd 8844 2 , , , cord-010119-t1x9gknd 8844 3 the the DT cord-010119-t1x9gknd 8844 4 automated automate VBN cord-010119-t1x9gknd 8844 5 analyzers analyzer NNS cord-010119-t1x9gknd 8844 6 consistently consistently RB cord-010119-t1x9gknd 8844 7 yielded yield VBD cord-010119-t1x9gknd 8844 8 higher high JJR cord-010119-t1x9gknd 8844 9 values value NNS cord-010119-t1x9gknd 8844 10 , , , cord-010119-t1x9gknd 8844 11 particularly particularly RB cord-010119-t1x9gknd 8844 12 with with IN cord-010119-t1x9gknd 8844 13 Rh Rh NNP cord-010119-t1x9gknd 8844 14 D D NNP cord-010119-t1x9gknd 8844 15 , , , cord-010119-t1x9gknd 8844 16 with with IN cord-010119-t1x9gknd 8844 17 results result NNS cord-010119-t1x9gknd 8844 18 $ $ $ cord-010119-t1x9gknd 8844 19 3 3 CD cord-010119-t1x9gknd 8844 20 times time NNS cord-010119-t1x9gknd 8844 21 higher high JJR cord-010119-t1x9gknd 8844 22 than than IN cord-010119-t1x9gknd 8844 23 in in IN cord-010119-t1x9gknd 8844 24 manual manual JJ cord-010119-t1x9gknd 8844 25 tube tube NN cord-010119-t1x9gknd 8844 26 testing testing NN cord-010119-t1x9gknd 8844 27 . . . cord-010119-t1x9gknd 8845 1 Interestingly interestingly RB cord-010119-t1x9gknd 8845 2 , , , cord-010119-t1x9gknd 8845 3 the the DT cord-010119-t1x9gknd 8845 4 difference difference NN cord-010119-t1x9gknd 8845 5 in in IN cord-010119-t1x9gknd 8845 6 titers titer NNS cord-010119-t1x9gknd 8845 7 of of IN cord-010119-t1x9gknd 8845 8 non non JJ cord-010119-t1x9gknd 8845 9 Rh Rh NNP cord-010119-t1x9gknd 8845 10 antibodies antibody NNS cord-010119-t1x9gknd 8845 11 between between IN cord-010119-t1x9gknd 8845 12 manual manual JJ cord-010119-t1x9gknd 8845 13 tube tube NN cord-010119-t1x9gknd 8845 14 and and CC cord-010119-t1x9gknd 8845 15 automated automate VBN cord-010119-t1x9gknd 8845 16 testing testing NN cord-010119-t1x9gknd 8845 17 was be VBD cord-010119-t1x9gknd 8845 18 not not RB cord-010119-t1x9gknd 8845 19 statistically statistically RB cord-010119-t1x9gknd 8845 20 significant significant JJ cord-010119-t1x9gknd 8845 21 , , , cord-010119-t1x9gknd 8845 22 although although IN cord-010119-t1x9gknd 8845 23 our -PRON- PRP$ cord-010119-t1x9gknd 8845 24 n n NN cord-010119-t1x9gknd 8845 25 thus thus RB cord-010119-t1x9gknd 8845 26 far far RB cord-010119-t1x9gknd 8845 27 is be VBZ cord-010119-t1x9gknd 8845 28 small small JJ cord-010119-t1x9gknd 8845 29 . . . cord-010119-t1x9gknd 8846 1 In in IN cord-010119-t1x9gknd 8846 2 order order NN cord-010119-t1x9gknd 8846 3 to to TO cord-010119-t1x9gknd 8846 4 leverage leverage VB cord-010119-t1x9gknd 8846 5 the the DT cord-010119-t1x9gknd 8846 6 efficiency efficiency NN cord-010119-t1x9gknd 8846 7 and and CC cord-010119-t1x9gknd 8846 8 reproducibility reproducibility NN cord-010119-t1x9gknd 8846 9 benefits benefit NNS cord-010119-t1x9gknd 8846 10 of of IN cord-010119-t1x9gknd 8846 11 automated automate VBN cord-010119-t1x9gknd 8846 12 titering titering NN cord-010119-t1x9gknd 8846 13 we -PRON- PRP cord-010119-t1x9gknd 8846 14 will will MD cord-010119-t1x9gknd 8846 15 need need VB cord-010119-t1x9gknd 8846 16 to to TO cord-010119-t1x9gknd 8846 17 establish establish VB cord-010119-t1x9gknd 8846 18 " " `` cord-010119-t1x9gknd 8846 19 critical critical JJ cord-010119-t1x9gknd 8846 20 titer titer NN cord-010119-t1x9gknd 8846 21 ranges range NNS cord-010119-t1x9gknd 8846 22 " " '' cord-010119-t1x9gknd 8846 23 which which WDT cord-010119-t1x9gknd 8846 24 require require VBP cord-010119-t1x9gknd 8846 25 active active JJ cord-010119-t1x9gknd 8846 26 monitoring monitoring NN cord-010119-t1x9gknd 8846 27 of of IN cord-010119-t1x9gknd 8846 28 the the DT cord-010119-t1x9gknd 8846 29 fetus fetus NN cord-010119-t1x9gknd 8846 30 . . . cord-010119-t1x9gknd 8847 1 Platelet platelet NN cord-010119-t1x9gknd 8847 2 Additive Additive NNP cord-010119-t1x9gknd 8847 3 Solution Solution NNP cord-010119-t1x9gknd 8847 4 Reduces reduce VBZ cord-010119-t1x9gknd 8847 5 the the DT cord-010119-t1x9gknd 8847 6 Isoagglutinin Isoagglutinin NNP cord-010119-t1x9gknd 8847 7 Titer Titer NNP cord-010119-t1x9gknd 8847 8 in in IN cord-010119-t1x9gknd 8847 9 Apheresis Apheresis NNP cord-010119-t1x9gknd 8847 10 Platelet Platelet NNP cord-010119-t1x9gknd 8847 11 Units Units NNP cord-010119-t1x9gknd 8847 12 Maxim Maxim NNP cord-010119-t1x9gknd 8847 13 Tynuv Tynuv NNP cord-010119-t1x9gknd 8847 14 * * NFP cord-010119-t1x9gknd 8847 15 , , , cord-010119-t1x9gknd 8847 16 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 8847 17 J J NNP cord-010119-t1x9gknd 8847 18 Furlong Furlong NNP cord-010119-t1x9gknd 8847 19 and and CC cord-010119-t1x9gknd 8847 20 Willy Willy NNP cord-010119-t1x9gknd 8847 21 A A NNP cord-010119-t1x9gknd 8847 22 Flegel Flegel NNP cord-010119-t1x9gknd 8847 23 . . . cord-010119-t1x9gknd 8848 1 DTM DTM NNP cord-010119-t1x9gknd 8848 2 / / SYM cord-010119-t1x9gknd 8848 3 CC CC NNP cord-010119-t1x9gknd 8848 4 / / SYM cord-010119-t1x9gknd 8848 5 NIH NIH NNP cord-010119-t1x9gknd 8848 6 Background Background NNP cord-010119-t1x9gknd 8848 7 / / SYM cord-010119-t1x9gknd 8848 8 Case Case NNP cord-010119-t1x9gknd 8848 9 Studies Studies NNPS cord-010119-t1x9gknd 8848 10 : : : cord-010119-t1x9gknd 8849 1 Isoagglutinins Isoagglutinins NNP cord-010119-t1x9gknd 8849 2 in in IN cord-010119-t1x9gknd 8849 3 the the DT cord-010119-t1x9gknd 8849 4 plasma plasma NN cord-010119-t1x9gknd 8849 5 of of IN cord-010119-t1x9gknd 8849 6 apheresis apheresis NN cord-010119-t1x9gknd 8849 7 platelets platelet NNS cord-010119-t1x9gknd 8849 8 are be VBP cord-010119-t1x9gknd 8849 9 a a DT cord-010119-t1x9gknd 8849 10 concern concern NN cord-010119-t1x9gknd 8849 11 during during IN cord-010119-t1x9gknd 8849 12 transfusion transfusion NN cord-010119-t1x9gknd 8849 13 , , , cord-010119-t1x9gknd 8849 14 as as IN cord-010119-t1x9gknd 8849 15 high high JJ cord-010119-t1x9gknd 8849 16 titer titer NN cord-010119-t1x9gknd 8849 17 anti anti NN cord-010119-t1x9gknd 8849 18 - - NNP cord-010119-t1x9gknd 8849 19 A a NN cord-010119-t1x9gknd 8849 20 and/or and/or CC cord-010119-t1x9gknd 8849 21 anti anti JJ cord-010119-t1x9gknd 8849 22 - - NN cord-010119-t1x9gknd 8849 23 B b NN cord-010119-t1x9gknd 8849 24 may may MD cord-010119-t1x9gknd 8849 25 cause cause VB cord-010119-t1x9gknd 8849 26 a a DT cord-010119-t1x9gknd 8849 27 hemolytic hemolytic JJ cord-010119-t1x9gknd 8849 28 transfusion transfusion NN cord-010119-t1x9gknd 8849 29 reaction reaction NN cord-010119-t1x9gknd 8849 30 ( ( -LRB- cord-010119-t1x9gknd 8849 31 HTR HTR NNP cord-010119-t1x9gknd 8849 32 ) ) -RRB- cord-010119-t1x9gknd 8849 33 in in IN cord-010119-t1x9gknd 8849 34 a a DT cord-010119-t1x9gknd 8849 35 recipient recipient NN cord-010119-t1x9gknd 8849 36 with with IN cord-010119-t1x9gknd 8849 37 cognate cognate JJ cord-010119-t1x9gknd 8849 38 antigen antigen NN cord-010119-t1x9gknd 8849 39 . . . cord-010119-t1x9gknd 8850 1 Apheresis apheresis NN cord-010119-t1x9gknd 8850 2 platelet platelet NN cord-010119-t1x9gknd 8850 3 collections collection NNS cord-010119-t1x9gknd 8850 4 are be VBP cord-010119-t1x9gknd 8850 5 usually usually RB cord-010119-t1x9gknd 8850 6 reconstituted reconstitute VBN cord-010119-t1x9gknd 8850 7 with with IN cord-010119-t1x9gknd 8850 8 donor donor NN cord-010119-t1x9gknd 8850 9 plasma plasma NN cord-010119-t1x9gknd 8850 10 , , , cord-010119-t1x9gknd 8850 11 however however RB cord-010119-t1x9gknd 8850 12 most most JJS cord-010119-t1x9gknd 8850 13 facilities facility NNS cord-010119-t1x9gknd 8850 14 do do VBP cord-010119-t1x9gknd 8850 15 not not RB cord-010119-t1x9gknd 8850 16 test test VB cord-010119-t1x9gknd 8850 17 for for IN cord-010119-t1x9gknd 8850 18 high high JJ cord-010119-t1x9gknd 8850 19 titer titer NN cord-010119-t1x9gknd 8850 20 of of IN cord-010119-t1x9gknd 8850 21 isoagglutinins isoagglutinin NNS cord-010119-t1x9gknd 8850 22 , , , cord-010119-t1x9gknd 8850 23 exposing expose VBG cord-010119-t1x9gknd 8850 24 recipients recipient NNS cord-010119-t1x9gknd 8850 25 to to IN cord-010119-t1x9gknd 8850 26 the the DT cord-010119-t1x9gknd 8850 27 risk risk NN cord-010119-t1x9gknd 8850 28 of of IN cord-010119-t1x9gknd 8850 29 HTR HTR NNP cord-010119-t1x9gknd 8850 30 due due JJ cord-010119-t1x9gknd 8850 31 to to IN cord-010119-t1x9gknd 8850 32 plasma plasma NN cord-010119-t1x9gknd 8850 33 incompatibility incompatibility NN cord-010119-t1x9gknd 8850 34 if if IN cord-010119-t1x9gknd 8850 35 given give VBN cord-010119-t1x9gknd 8850 36 based base VBN cord-010119-t1x9gknd 8850 37 on on IN cord-010119-t1x9gknd 8850 38 short short JJ cord-010119-t1x9gknd 8850 39 outdate outdate RB cord-010119-t1x9gknd 8850 40 and and CC cord-010119-t1x9gknd 8850 41 not not RB cord-010119-t1x9gknd 8850 42 ABO ABO NNP cord-010119-t1x9gknd 8850 43 type type NN cord-010119-t1x9gknd 8850 44 . . . cord-010119-t1x9gknd 8851 1 At at IN cord-010119-t1x9gknd 8851 2 our -PRON- PRP$ cord-010119-t1x9gknd 8851 3 facility facility NN cord-010119-t1x9gknd 8851 4 testing testing NN cord-010119-t1x9gknd 8851 5 is be VBZ cord-010119-t1x9gknd 8851 6 performed perform VBN cord-010119-t1x9gknd 8851 7 on on IN cord-010119-t1x9gknd 8851 8 all all DT cord-010119-t1x9gknd 8851 9 apheresis apheresis NN cord-010119-t1x9gknd 8851 10 platelets platelet NNS cord-010119-t1x9gknd 8851 11 with with IN cord-010119-t1x9gknd 8851 12 a a DT cord-010119-t1x9gknd 8851 13 cutoff cutoff NN cord-010119-t1x9gknd 8851 14 titer titer NN cord-010119-t1x9gknd 8851 15 of of IN cord-010119-t1x9gknd 8851 16 250 250 CD cord-010119-t1x9gknd 8851 17 . . . cord-010119-t1x9gknd 8852 1 Units unit NNS cord-010119-t1x9gknd 8852 2 above above IN cord-010119-t1x9gknd 8852 3 the the DT cord-010119-t1x9gknd 8852 4 cutoff cutoff NN cord-010119-t1x9gknd 8852 5 are be VBP cord-010119-t1x9gknd 8852 6 marked mark VBN cord-010119-t1x9gknd 8852 7 as as IN cord-010119-t1x9gknd 8852 8 " " `` cord-010119-t1x9gknd 8852 9 high high JJ cord-010119-t1x9gknd 8852 10 titer titer NN cord-010119-t1x9gknd 8852 11 " " '' cord-010119-t1x9gknd 8852 12 and and CC cord-010119-t1x9gknd 8852 13 only only RB cord-010119-t1x9gknd 8852 14 given give VBN cord-010119-t1x9gknd 8852 15 to to IN cord-010119-t1x9gknd 8852 16 ABO ABO NNP cord-010119-t1x9gknd 8852 17 plasma plasma NN cord-010119-t1x9gknd 8852 18 - - HYPH cord-010119-t1x9gknd 8852 19 compatible compatible JJ cord-010119-t1x9gknd 8852 20 recipients recipient NNS cord-010119-t1x9gknd 8852 21 or or CC cord-010119-t1x9gknd 8852 22 washed wash VBN cord-010119-t1x9gknd 8852 23 with with IN cord-010119-t1x9gknd 8852 24 saline saline NN cord-010119-t1x9gknd 8852 25 to to TO cord-010119-t1x9gknd 8852 26 reduce reduce VB cord-010119-t1x9gknd 8852 27 plasma plasma NN cord-010119-t1x9gknd 8852 28 . . . cord-010119-t1x9gknd 8853 1 However however RB cord-010119-t1x9gknd 8853 2 , , , cord-010119-t1x9gknd 8853 3 washing washing NN cord-010119-t1x9gknd 8853 4 platelets platelet NNS cord-010119-t1x9gknd 8853 5 is be VBZ cord-010119-t1x9gknd 8853 6 a a DT cord-010119-t1x9gknd 8853 7 time time NN cord-010119-t1x9gknd 8853 8 consuming consume VBG cord-010119-t1x9gknd 8853 9 process process NN cord-010119-t1x9gknd 8853 10 that that WDT cord-010119-t1x9gknd 8853 11 results result VBZ cord-010119-t1x9gknd 8853 12 in in IN cord-010119-t1x9gknd 8853 13 a a DT cord-010119-t1x9gknd 8853 14 loss loss NN cord-010119-t1x9gknd 8853 15 of of IN cord-010119-t1x9gknd 8853 16 up up IN cord-010119-t1x9gknd 8853 17 to to TO cord-010119-t1x9gknd 8853 18 33 33 CD cord-010119-t1x9gknd 8853 19 % % NN cord-010119-t1x9gknd 8853 20 of of IN cord-010119-t1x9gknd 8853 21 the the DT cord-010119-t1x9gknd 8853 22 platelets platelet NNS cord-010119-t1x9gknd 8853 23 . . . cord-010119-t1x9gknd 8854 1 Platelet platelet NN cord-010119-t1x9gknd 8854 2 additive additive NN cord-010119-t1x9gknd 8854 3 solution solution NN cord-010119-t1x9gknd 8854 4 ( ( -LRB- cord-010119-t1x9gknd 8854 5 PAS pas NN cord-010119-t1x9gknd 8854 6 ) ) -RRB- cord-010119-t1x9gknd 8854 7 is be VBZ cord-010119-t1x9gknd 8854 8 used use VBN cord-010119-t1x9gknd 8854 9 as as IN cord-010119-t1x9gknd 8854 10 an an DT cord-010119-t1x9gknd 8854 11 alternative alternative JJ cord-010119-t1x9gknd 8854 12 collection collection NN cord-010119-t1x9gknd 8854 13 and and CC cord-010119-t1x9gknd 8854 14 storage storage NN cord-010119-t1x9gknd 8854 15 solution solution NN cord-010119-t1x9gknd 8854 16 , , , cord-010119-t1x9gknd 8854 17 replacing replace VBG cord-010119-t1x9gknd 8854 18 approximately approximately RB cord-010119-t1x9gknd 8854 19 65 65 CD cord-010119-t1x9gknd 8854 20 % % NN cord-010119-t1x9gknd 8854 21 of of IN cord-010119-t1x9gknd 8854 22 donor donor NN cord-010119-t1x9gknd 8854 23 plasma plasma NN cord-010119-t1x9gknd 8854 24 in in IN cord-010119-t1x9gknd 8854 25 the the DT cord-010119-t1x9gknd 8854 26 final final JJ cord-010119-t1x9gknd 8854 27 product product NN cord-010119-t1x9gknd 8854 28 . . . cord-010119-t1x9gknd 8855 1 The the DT cord-010119-t1x9gknd 8855 2 goal goal NN cord-010119-t1x9gknd 8855 3 of of IN cord-010119-t1x9gknd 8855 4 this this DT cord-010119-t1x9gknd 8855 5 study study NN cord-010119-t1x9gknd 8855 6 was be VBD cord-010119-t1x9gknd 8855 7 to to TO cord-010119-t1x9gknd 8855 8 determine determine VB cord-010119-t1x9gknd 8855 9 what what WDT cord-010119-t1x9gknd 8855 10 affect affect NN cord-010119-t1x9gknd 8855 11 PAS PAS NNP cord-010119-t1x9gknd 8855 12 has have VBZ cord-010119-t1x9gknd 8855 13 on on IN cord-010119-t1x9gknd 8855 14 isoagglutinin isoagglutinin NNS cord-010119-t1x9gknd 8855 15 titers titer NNS cord-010119-t1x9gknd 8855 16 and and CC cord-010119-t1x9gknd 8855 17 whether whether IN cord-010119-t1x9gknd 8855 18 using use VBG cord-010119-t1x9gknd 8855 19 PAS PAS NNP cord-010119-t1x9gknd 8855 20 could could MD cord-010119-t1x9gknd 8855 21 lead lead VB cord-010119-t1x9gknd 8855 22 to to IN cord-010119-t1x9gknd 8855 23 a a DT cord-010119-t1x9gknd 8855 24 revision revision NN cord-010119-t1x9gknd 8855 25 of of IN cord-010119-t1x9gknd 8855 26 one one CD cord-010119-t1x9gknd 8855 27 facility facility NN cord-010119-t1x9gknd 8855 28 's 's POS cord-010119-t1x9gknd 8855 29 procedure procedure NN cord-010119-t1x9gknd 8855 30 for for IN cord-010119-t1x9gknd 8855 31 management management NN cord-010119-t1x9gknd 8855 32 out out IN cord-010119-t1x9gknd 8855 33 of of IN cord-010119-t1x9gknd 8855 34 group group NN cord-010119-t1x9gknd 8855 35 platelet platelet NN cord-010119-t1x9gknd 8855 36 transfusions transfusion NNS cord-010119-t1x9gknd 8855 37 . . . cord-010119-t1x9gknd 8856 1 Study Study NNP cord-010119-t1x9gknd 8856 2 Design Design NNP cord-010119-t1x9gknd 8856 3 / / SYM cord-010119-t1x9gknd 8856 4 Method method NN cord-010119-t1x9gknd 8856 5 : : : cord-010119-t1x9gknd 8857 1 Isoagglutinin Isoagglutinin NNS cord-010119-t1x9gknd 8857 2 titers titer NNS cord-010119-t1x9gknd 8857 3 of of IN cord-010119-t1x9gknd 8857 4 whole whole JJ cord-010119-t1x9gknd 8857 5 blood blood NN cord-010119-t1x9gknd 8857 6 EDTA edta NN cord-010119-t1x9gknd 8857 7 samples sample NNS cord-010119-t1x9gknd 8857 8 were be VBD cord-010119-t1x9gknd 8857 9 compared compare VBN cord-010119-t1x9gknd 8857 10 to to IN cord-010119-t1x9gknd 8857 11 the the DT cord-010119-t1x9gknd 8857 12 final final JJ cord-010119-t1x9gknd 8857 13 apheresis apheresis NN cord-010119-t1x9gknd 8857 14 platelet platelet NN cord-010119-t1x9gknd 8857 15 unit unit NN cord-010119-t1x9gknd 8857 16 collected collect VBN cord-010119-t1x9gknd 8857 17 in in IN cord-010119-t1x9gknd 8857 18 PAS pas FW cord-010119-t1x9gknd 8857 19 ( ( -LRB- cord-010119-t1x9gknd 8857 20 Intersol Intersol NNP cord-010119-t1x9gknd 8857 21 , , , cord-010119-t1x9gknd 8857 22 Fresenius Fresenius NNP cord-010119-t1x9gknd 8857 23 Kabi Kabi NNP cord-010119-t1x9gknd 8857 24 , , , cord-010119-t1x9gknd 8857 25 Lake Lake NNP cord-010119-t1x9gknd 8857 26 Zurich Zurich NNP cord-010119-t1x9gknd 8857 27 , , , cord-010119-t1x9gknd 8857 28 IL IL NNP cord-010119-t1x9gknd 8857 29 ) ) -RRB- cord-010119-t1x9gknd 8857 30 . . . cord-010119-t1x9gknd 8858 1 Using use VBG cord-010119-t1x9gknd 8858 2 two two CD cord-010119-t1x9gknd 8858 3 - - HYPH cord-010119-t1x9gknd 8858 4 fold fold NN cord-010119-t1x9gknd 8858 5 dilution dilution NN cord-010119-t1x9gknd 8858 6 steps step NNS cord-010119-t1x9gknd 8858 7 , , , cord-010119-t1x9gknd 8858 8 plasma plasma NN cord-010119-t1x9gknd 8858 9 was be VBD cord-010119-t1x9gknd 8858 10 tested test VBN cord-010119-t1x9gknd 8858 11 with with IN cord-010119-t1x9gknd 8858 12 pooled pool VBN cord-010119-t1x9gknd 8858 13 red red JJ cord-010119-t1x9gknd 8858 14 cells cell NNS cord-010119-t1x9gknd 8858 15 ( ( -LRB- cord-010119-t1x9gknd 8858 16 equal equal JJ cord-010119-t1x9gknd 8858 17 mix mix NN cord-010119-t1x9gknd 8858 18 0.8 0.8 CD cord-010119-t1x9gknd 8858 19 % % NN cord-010119-t1x9gknd 8858 20 suspension suspension NN cord-010119-t1x9gknd 8858 21 of of IN cord-010119-t1x9gknd 8858 22 A1 a1 NN cord-010119-t1x9gknd 8858 23 and and CC cord-010119-t1x9gknd 8858 24 B B NNP cord-010119-t1x9gknd 8858 25 cells cell NNS cord-010119-t1x9gknd 8858 26 , , , cord-010119-t1x9gknd 8858 27 Ortho Ortho NNP cord-010119-t1x9gknd 8858 28 , , , cord-010119-t1x9gknd 8858 29 Raritan Raritan NNP cord-010119-t1x9gknd 8858 30 , , , cord-010119-t1x9gknd 8858 31 NJ NJ NNP cord-010119-t1x9gknd 8858 32 ) ) -RRB- cord-010119-t1x9gknd 8858 33 in in IN cord-010119-t1x9gknd 8858 34 a a DT cord-010119-t1x9gknd 8858 35 gel gel NN cord-010119-t1x9gknd 8858 36 matrix matrix NN cord-010119-t1x9gknd 8858 37 test test NN cord-010119-t1x9gknd 8858 38 ( ( -LRB- cord-010119-t1x9gknd 8858 39 MTS MTS NNP cord-010119-t1x9gknd 8858 40 Buffered Buffered NNP cord-010119-t1x9gknd 8858 41 card card NN cord-010119-t1x9gknd 8858 42 , , , cord-010119-t1x9gknd 8858 43 Ortho Ortho NNP cord-010119-t1x9gknd 8858 44 , , , cord-010119-t1x9gknd 8858 45 Raritan Raritan NNP cord-010119-t1x9gknd 8858 46 , , , cord-010119-t1x9gknd 8858 47 NJ NJ NNP cord-010119-t1x9gknd 8858 48 ) ) -RRB- cord-010119-t1x9gknd 8858 49 with with IN cord-010119-t1x9gknd 8858 50 15 15 CD cord-010119-t1x9gknd 8858 51 min min NN cord-010119-t1x9gknd 8858 52 incubation incubation NN cord-010119-t1x9gknd 8858 53 ( ( -LRB- cord-010119-t1x9gknd 8858 54 room room NN cord-010119-t1x9gknd 8858 55 temperature temperature NN cord-010119-t1x9gknd 8858 56 ) ) -RRB- cord-010119-t1x9gknd 8858 57 prior prior RB cord-010119-t1x9gknd 8858 58 to to IN cord-010119-t1x9gknd 8858 59 centrifugation centrifugation NN cord-010119-t1x9gknd 8858 60 ( ( -LRB- cord-010119-t1x9gknd 8858 61 MTS MTS NNP cord-010119-t1x9gknd 8858 62 Ortho Ortho NNP cord-010119-t1x9gknd 8858 63 Workstation Workstation NNP cord-010119-t1x9gknd 8858 64 ) ) -RRB- cord-010119-t1x9gknd 8858 65 . . . cord-010119-t1x9gknd 8859 1 Fifty fifty CD cord-010119-t1x9gknd 8859 2 two two CD cord-010119-t1x9gknd 8859 3 donors donor NNS cord-010119-t1x9gknd 8859 4 were be VBD cord-010119-t1x9gknd 8859 5 group group NN cord-010119-t1x9gknd 8859 6 O o NN cord-010119-t1x9gknd 8859 7 , , , cord-010119-t1x9gknd 8859 8 32 32 CD cord-010119-t1x9gknd 8859 9 group group NN cord-010119-t1x9gknd 8859 10 A A NNP cord-010119-t1x9gknd 8859 11 , , , cord-010119-t1x9gknd 8859 12 and and CC cord-010119-t1x9gknd 8859 13 16 16 CD cord-010119-t1x9gknd 8859 14 group group NN cord-010119-t1x9gknd 8859 15 B. B. NNP cord-010119-t1x9gknd 8859 16 Results Results NNP cord-010119-t1x9gknd 8859 17 / / SYM cord-010119-t1x9gknd 8859 18 Finding finding NN cord-010119-t1x9gknd 8859 19 : : : cord-010119-t1x9gknd 8859 20 Of of IN cord-010119-t1x9gknd 8859 21 the the DT cord-010119-t1x9gknd 8859 22 100 100 CD cord-010119-t1x9gknd 8859 23 whole whole JJ cord-010119-t1x9gknd 8859 24 blood blood NN cord-010119-t1x9gknd 8859 25 EDTA edta NN cord-010119-t1x9gknd 8859 26 samples sample NNS cord-010119-t1x9gknd 8859 27 tested test VBN cord-010119-t1x9gknd 8859 28 , , , cord-010119-t1x9gknd 8859 29 26 26 CD cord-010119-t1x9gknd 8859 30 ( ( -LRB- cord-010119-t1x9gknd 8859 31 25 25 CD cord-010119-t1x9gknd 8859 32 Group Group NNP cord-010119-t1x9gknd 8859 33 O O NNP cord-010119-t1x9gknd 8859 34 and and CC cord-010119-t1x9gknd 8859 35 1Group 1Group NNP cord-010119-t1x9gknd 8859 36 B B NNP cord-010119-t1x9gknd 8859 37 ) ) -RRB- cord-010119-t1x9gknd 8859 38 exceeded exceed VBD cord-010119-t1x9gknd 8859 39 a a DT cord-010119-t1x9gknd 8859 40 high high JJ cord-010119-t1x9gknd 8859 41 titer titer NN cord-010119-t1x9gknd 8859 42 threshold threshold NN cord-010119-t1x9gknd 8859 43 of of IN cord-010119-t1x9gknd 8859 44 250 250 CD cord-010119-t1x9gknd 8859 45 . . . cord-010119-t1x9gknd 8860 1 When when WRB cord-010119-t1x9gknd 8860 2 the the DT cord-010119-t1x9gknd 8860 3 PAS pas NN cord-010119-t1x9gknd 8860 4 samples sample NNS cord-010119-t1x9gknd 8860 5 of of IN cord-010119-t1x9gknd 8860 6 these these DT cord-010119-t1x9gknd 8860 7 26 26 CD cord-010119-t1x9gknd 8860 8 donors donor NNS cord-010119-t1x9gknd 8860 9 were be VBD cord-010119-t1x9gknd 8860 10 tested test VBN cord-010119-t1x9gknd 8860 11 , , , cord-010119-t1x9gknd 8860 12 only only RB cord-010119-t1x9gknd 8860 13 one one CD cord-010119-t1x9gknd 8860 14 ( ( -LRB- cord-010119-t1x9gknd 8860 15 Group Group NNP cord-010119-t1x9gknd 8860 16 O O NNP cord-010119-t1x9gknd 8860 17 ) ) -RRB- cord-010119-t1x9gknd 8860 18 exceeded exceed VBD cord-010119-t1x9gknd 8860 19 the the DT cord-010119-t1x9gknd 8860 20 same same JJ cord-010119-t1x9gknd 8860 21 threshold threshold NN cord-010119-t1x9gknd 8860 22 . . . cord-010119-t1x9gknd 8861 1 PAS pas NN cord-010119-t1x9gknd 8861 2 specimens specimen NNS cord-010119-t1x9gknd 8861 3 showed show VBD cord-010119-t1x9gknd 8861 4 a a DT cord-010119-t1x9gknd 8861 5 consistent consistent JJ cord-010119-t1x9gknd 8861 6 two two CD cord-010119-t1x9gknd 8861 7 - - HYPH cord-010119-t1x9gknd 8861 8 fold fold JJ cord-010119-t1x9gknd 8861 9 decrease decrease NN cord-010119-t1x9gknd 8861 10 in in IN cord-010119-t1x9gknd 8861 11 titer titer NN cord-010119-t1x9gknd 8861 12 compared compare VBN cord-010119-t1x9gknd 8861 13 with with IN cord-010119-t1x9gknd 8861 14 whole whole JJ cord-010119-t1x9gknd 8861 15 blood blood NN cord-010119-t1x9gknd 8861 16 specimens specimen NNS cord-010119-t1x9gknd 8861 17 . . . cord-010119-t1x9gknd 8862 1 Nearly nearly RB cord-010119-t1x9gknd 8862 2 half half NN cord-010119-t1x9gknd 8862 3 of of IN cord-010119-t1x9gknd 8862 4 the the DT cord-010119-t1x9gknd 8862 5 group group NN cord-010119-t1x9gknd 8862 6 O o NN cord-010119-t1x9gknd 8862 7 donors donor NNS cord-010119-t1x9gknd 8862 8 exceeded exceed VBD cord-010119-t1x9gknd 8862 9 a a DT cord-010119-t1x9gknd 8862 10 titer titer NN cord-010119-t1x9gknd 8862 11 of of IN cord-010119-t1x9gknd 8862 12 250 250 CD cord-010119-t1x9gknd 8862 13 when when WRB cord-010119-t1x9gknd 8862 14 whole whole JJ cord-010119-t1x9gknd 8862 15 blood blood NN cord-010119-t1x9gknd 8862 16 specimens specimen NNS cord-010119-t1x9gknd 8862 17 were be VBD cord-010119-t1x9gknd 8862 18 tested test VBN cord-010119-t1x9gknd 8862 19 . . . cord-010119-t1x9gknd 8863 1 Conclusion conclusion NN cord-010119-t1x9gknd 8863 2 : : : cord-010119-t1x9gknd 8863 3 Only only RB cord-010119-t1x9gknd 8863 4 one one CD cord-010119-t1x9gknd 8863 5 sample sample NN cord-010119-t1x9gknd 8863 6 from from IN cord-010119-t1x9gknd 8863 7 apheresis apheresis NN cord-010119-t1x9gknd 8863 8 platelets platelet NNS cord-010119-t1x9gknd 8863 9 collected collect VBN cord-010119-t1x9gknd 8863 10 in in IN cord-010119-t1x9gknd 8863 11 PAS pas NN cord-010119-t1x9gknd 8863 12 exceeded exceed VBD cord-010119-t1x9gknd 8863 13 our -PRON- PRP$ cord-010119-t1x9gknd 8863 14 clinically clinically RB cord-010119-t1x9gknd 8863 15 applied apply VBN cord-010119-t1x9gknd 8863 16 titer titer NN cord-010119-t1x9gknd 8863 17 threshold threshold NN cord-010119-t1x9gknd 8863 18 of of IN cord-010119-t1x9gknd 8863 19 250 250 CD cord-010119-t1x9gknd 8863 20 , , , cord-010119-t1x9gknd 8863 21 a a DT cord-010119-t1x9gknd 8863 22 96 96 CD cord-010119-t1x9gknd 8863 23 % % NN cord-010119-t1x9gknd 8863 24 decrease decrease NN cord-010119-t1x9gknd 8863 25 from from IN cord-010119-t1x9gknd 8863 26 the the DT cord-010119-t1x9gknd 8863 27 number number NN cord-010119-t1x9gknd 8863 28 of of IN cord-010119-t1x9gknd 8863 29 whole whole JJ cord-010119-t1x9gknd 8863 30 blood blood NN cord-010119-t1x9gknd 8863 31 specimens specimen NNS cord-010119-t1x9gknd 8863 32 exceeding exceed VBG cord-010119-t1x9gknd 8863 33 the the DT cord-010119-t1x9gknd 8863 34 threshold threshold NN cord-010119-t1x9gknd 8863 35 . . . cord-010119-t1x9gknd 8864 1 Testing test VBG cord-010119-t1x9gknd 8864 2 the the DT cord-010119-t1x9gknd 8864 3 platelet platelet NN cord-010119-t1x9gknd 8864 4 bag bag NN cord-010119-t1x9gknd 8864 5 collected collect VBN cord-010119-t1x9gknd 8864 6 in in IN cord-010119-t1x9gknd 8864 7 PAS pas NN cord-010119-t1x9gknd 8864 8 instead instead RB cord-010119-t1x9gknd 8864 9 of of IN cord-010119-t1x9gknd 8864 10 plasma plasma NN cord-010119-t1x9gknd 8864 11 from from IN cord-010119-t1x9gknd 8864 12 whole whole JJ cord-010119-t1x9gknd 8864 13 blood blood NN cord-010119-t1x9gknd 8864 14 specimens specimen NNS cord-010119-t1x9gknd 8864 15 would would MD cord-010119-t1x9gknd 8864 16 lower lower VB cord-010119-t1x9gknd 8864 17 the the DT cord-010119-t1x9gknd 8864 18 number number NN cord-010119-t1x9gknd 8864 19 of of IN cord-010119-t1x9gknd 8864 20 units unit NNS cord-010119-t1x9gknd 8864 21 exceeding exceed VBG cord-010119-t1x9gknd 8864 22 the the DT cord-010119-t1x9gknd 8864 23 high high JJ cord-010119-t1x9gknd 8864 24 titer titer NN cord-010119-t1x9gknd 8864 25 threshold threshold NN cord-010119-t1x9gknd 8864 26 , , , cord-010119-t1x9gknd 8864 27 and and CC cord-010119-t1x9gknd 8864 28 reduce reduce VB cord-010119-t1x9gknd 8864 29 products product NNS cord-010119-t1x9gknd 8864 30 needing need VBG cord-010119-t1x9gknd 8864 31 to to TO cord-010119-t1x9gknd 8864 32 be be VB cord-010119-t1x9gknd 8864 33 washed wash VBN cord-010119-t1x9gknd 8864 34 . . . cord-010119-t1x9gknd 8865 1 Furthermore furthermore RB cord-010119-t1x9gknd 8865 2 , , , cord-010119-t1x9gknd 8865 3 facilities facility NNS cord-010119-t1x9gknd 8865 4 not not RB cord-010119-t1x9gknd 8865 5 collecting collect VBG cord-010119-t1x9gknd 8865 6 platelets platelet NNS cord-010119-t1x9gknd 8865 7 on on IN cord-010119-t1x9gknd 8865 8 site site NN cord-010119-t1x9gknd 8865 9 or or CC cord-010119-t1x9gknd 8865 10 without without IN cord-010119-t1x9gknd 8865 11 access access NN cord-010119-t1x9gknd 8865 12 to to IN cord-010119-t1x9gknd 8865 13 whole whole JJ cord-010119-t1x9gknd 8865 14 blood blood NN cord-010119-t1x9gknd 8865 15 specimens specimen NNS cord-010119-t1x9gknd 8865 16 from from IN cord-010119-t1x9gknd 8865 17 donors donor NNS cord-010119-t1x9gknd 8865 18 could could MD cord-010119-t1x9gknd 8865 19 implement implement VB cord-010119-t1x9gknd 8865 20 the the DT cord-010119-t1x9gknd 8865 21 process process NN cord-010119-t1x9gknd 8865 22 described describe VBN cord-010119-t1x9gknd 8865 23 here here RB cord-010119-t1x9gknd 8865 24 and and CC cord-010119-t1x9gknd 8865 25 screen screen NN cord-010119-t1x9gknd 8865 26 platelet platelet NN cord-010119-t1x9gknd 8865 27 apheresis apheresis NN cord-010119-t1x9gknd 8865 28 collections collection NNS cord-010119-t1x9gknd 8865 29 for for IN cord-010119-t1x9gknd 8865 30 potentially potentially RB cord-010119-t1x9gknd 8865 31 clinically clinically RB cord-010119-t1x9gknd 8865 32 adverse adverse JJ cord-010119-t1x9gknd 8865 33 isoagglutinin isoagglutinin NNS cord-010119-t1x9gknd 8865 34 titers titer NNS cord-010119-t1x9gknd 8865 35 , , , cord-010119-t1x9gknd 8865 36 whether whether IN cord-010119-t1x9gknd 8865 37 collected collect VBN cord-010119-t1x9gknd 8865 38 using use VBG cord-010119-t1x9gknd 8865 39 PAS pas NN cord-010119-t1x9gknd 8865 40 or or CC cord-010119-t1x9gknd 8865 41 not not RB cord-010119-t1x9gknd 8865 42 . . . cord-010119-t1x9gknd 8866 1 other other JJ cord-010119-t1x9gknd 8866 2 components component NNS cord-010119-t1x9gknd 8866 3 . . . cord-010119-t1x9gknd 8867 1 The the DT cord-010119-t1x9gknd 8867 2 majority majority NN cord-010119-t1x9gknd 8867 3 of of IN cord-010119-t1x9gknd 8867 4 blood blood NN cord-010119-t1x9gknd 8867 5 components component NNS cord-010119-t1x9gknd 8867 6 in in IN cord-010119-t1x9gknd 8867 7 Israel Israel NNP cord-010119-t1x9gknd 8867 8 are be VBP cord-010119-t1x9gknd 8867 9 collected collect VBN cord-010119-t1x9gknd 8867 10 and and CC cord-010119-t1x9gknd 8867 11 distributed distribute VBN cord-010119-t1x9gknd 8867 12 by by IN cord-010119-t1x9gknd 8867 13 Magen Magen NNP cord-010119-t1x9gknd 8867 14 David David NNP cord-010119-t1x9gknd 8867 15 Adom Adom NNP cord-010119-t1x9gknd 8867 16 ( ( -LRB- cord-010119-t1x9gknd 8867 17 MDA MDA NNP cord-010119-t1x9gknd 8867 18 ) ) -RRB- cord-010119-t1x9gknd 8867 19 , , , cord-010119-t1x9gknd 8867 20 from from IN cord-010119-t1x9gknd 8867 21 2 2 CD cord-010119-t1x9gknd 8867 22 main main JJ cord-010119-t1x9gknd 8867 23 locations location NNS cord-010119-t1x9gknd 8867 24 . . . cord-010119-t1x9gknd 8868 1 Several several JJ cord-010119-t1x9gknd 8868 2 hospitals hospital NNS cord-010119-t1x9gknd 8868 3 in in IN cord-010119-t1x9gknd 8868 4 Israel Israel NNP cord-010119-t1x9gknd 8868 5 also also RB cord-010119-t1x9gknd 8868 6 collect collect VBP cord-010119-t1x9gknd 8868 7 platelets platelet NNS cord-010119-t1x9gknd 8868 8 in in IN cord-010119-t1x9gknd 8868 9 - - HYPH cord-010119-t1x9gknd 8868 10 house house NN cord-010119-t1x9gknd 8868 11 . . . cord-010119-t1x9gknd 8869 1 As as IN cord-010119-t1x9gknd 8869 2 part part NN cord-010119-t1x9gknd 8869 3 of of IN cord-010119-t1x9gknd 8869 4 an an DT cord-010119-t1x9gknd 8869 5 effort effort NN cord-010119-t1x9gknd 8869 6 to to TO cord-010119-t1x9gknd 8869 7 understand understand VB cord-010119-t1x9gknd 8869 8 PLT PLT NNP cord-010119-t1x9gknd 8869 9 utilization utilization NN cord-010119-t1x9gknd 8869 10 , , , cord-010119-t1x9gknd 8869 11 a a DT cord-010119-t1x9gknd 8869 12 nationwide nationwide JJ cord-010119-t1x9gknd 8869 13 survey survey NN cord-010119-t1x9gknd 8869 14 of of IN cord-010119-t1x9gknd 8869 15 PLT PLT NNP cord-010119-t1x9gknd 8869 16 transfusion transfusion NN cord-010119-t1x9gknd 8869 17 and and CC cord-010119-t1x9gknd 8869 18 expiration expiration NN cord-010119-t1x9gknd 8869 19 was be VBD cord-010119-t1x9gknd 8869 20 conducted conduct VBN cord-010119-t1x9gknd 8869 21 . . . cord-010119-t1x9gknd 8870 1 Study Study NNP cord-010119-t1x9gknd 8870 2 Design Design NNP cord-010119-t1x9gknd 8870 3 / / SYM cord-010119-t1x9gknd 8870 4 Methods method NNS cord-010119-t1x9gknd 8870 5 : : : cord-010119-t1x9gknd 8871 1 Data datum NNS cord-010119-t1x9gknd 8871 2 on on IN cord-010119-t1x9gknd 8871 3 the the DT cord-010119-t1x9gknd 8871 4 disposition disposition NN cord-010119-t1x9gknd 8871 5 of of IN cord-010119-t1x9gknd 8871 6 all all DT cord-010119-t1x9gknd 8871 7 PLT PLT NNP cord-010119-t1x9gknd 8871 8 units unit NNS cord-010119-t1x9gknd 8871 9 , , , cord-010119-t1x9gknd 8871 10 acquired acquire VBD cord-010119-t1x9gknd 8871 11 from from IN cord-010119-t1x9gknd 8871 12 MDA MDA NNP cord-010119-t1x9gknd 8871 13 and and CC cord-010119-t1x9gknd 8871 14 collected collect VBN cord-010119-t1x9gknd 8871 15 in in IN cord-010119-t1x9gknd 8871 16 - - HYPH cord-010119-t1x9gknd 8871 17 house house NN cord-010119-t1x9gknd 8871 18 , , , cord-010119-t1x9gknd 8871 19 during during IN cord-010119-t1x9gknd 8871 20 the the DT cord-010119-t1x9gknd 8871 21 calendar calendar NN cord-010119-t1x9gknd 8871 22 year year NN cord-010119-t1x9gknd 8871 23 2016 2016 CD cord-010119-t1x9gknd 8871 24 was be VBD cord-010119-t1x9gknd 8871 25 requested request VBN cord-010119-t1x9gknd 8871 26 from from IN cord-010119-t1x9gknd 8871 27 all all DT cord-010119-t1x9gknd 8871 28 hospitals hospital NNS cord-010119-t1x9gknd 8871 29 in in IN cord-010119-t1x9gknd 8871 30 Israel Israel NNP cord-010119-t1x9gknd 8871 31 . . . cord-010119-t1x9gknd 8872 1 The the DT cord-010119-t1x9gknd 8872 2 number number NN cord-010119-t1x9gknd 8872 3 of of IN cord-010119-t1x9gknd 8872 4 PLT PLT NNP cord-010119-t1x9gknd 8872 5 distributed distribute VBN cord-010119-t1x9gknd 8872 6 to to IN cord-010119-t1x9gknd 8872 7 hospitals hospital NNS cord-010119-t1x9gknd 8872 8 by by IN cord-010119-t1x9gknd 8872 9 MDA MDA NNP cord-010119-t1x9gknd 8872 10 was be VBD cord-010119-t1x9gknd 8872 11 also also RB cord-010119-t1x9gknd 8872 12 collected collect VBN cord-010119-t1x9gknd 8872 13 . . . cord-010119-t1x9gknd 8873 1 PLT PLT NNP cord-010119-t1x9gknd 8873 2 wastage wastage NN cord-010119-t1x9gknd 8873 3 was be VBD cord-010119-t1x9gknd 8873 4 defined define VBN cord-010119-t1x9gknd 8873 5 as as IN cord-010119-t1x9gknd 8873 6 the the DT cord-010119-t1x9gknd 8873 7 sum sum NN cord-010119-t1x9gknd 8873 8 of of IN cord-010119-t1x9gknd 8873 9 PLT PLT NNP cord-010119-t1x9gknd 8873 10 that that WDT cord-010119-t1x9gknd 8873 11 were be VBD cord-010119-t1x9gknd 8873 12 returned return VBN cord-010119-t1x9gknd 8873 13 and and CC cord-010119-t1x9gknd 8873 14 not not RB cord-010119-t1x9gknd 8873 15 reissued reissue VBN cord-010119-t1x9gknd 8873 16 from from IN cord-010119-t1x9gknd 8873 17 the the DT cord-010119-t1x9gknd 8873 18 hospital hospital NN cord-010119-t1x9gknd 8873 19 blood blood NN cord-010119-t1x9gknd 8873 20 banks bank NNS cord-010119-t1x9gknd 8873 21 and and CC cord-010119-t1x9gknd 8873 22 PLT PLT NNP cord-010119-t1x9gknd 8873 23 that that WDT cord-010119-t1x9gknd 8873 24 expired expire VBD cord-010119-t1x9gknd 8873 25 on on IN cord-010119-t1x9gknd 8873 26 blood blood NN cord-010119-t1x9gknd 8873 27 bank bank NN cord-010119-t1x9gknd 8873 28 shelves shelf NNS cord-010119-t1x9gknd 8873 29 . . . cord-010119-t1x9gknd 8874 1 Results result NNS cord-010119-t1x9gknd 8874 2 / / SYM cord-010119-t1x9gknd 8874 3 Findings finding NNS cord-010119-t1x9gknd 8874 4 : : : cord-010119-t1x9gknd 8875 1 Sixteen sixteen CD cord-010119-t1x9gknd 8875 2 of of IN cord-010119-t1x9gknd 8875 3 the the DT cord-010119-t1x9gknd 8875 4 27(59 27(59 CD cord-010119-t1x9gknd 8875 5 % % NN cord-010119-t1x9gknd 8875 6 ) ) -RRB- cord-010119-t1x9gknd 8875 7 hospitals hospital NNS cord-010119-t1x9gknd 8875 8 in in IN cord-010119-t1x9gknd 8875 9 Israel Israel NNP cord-010119-t1x9gknd 8875 10 , , , cord-010119-t1x9gknd 8875 11 along along IN cord-010119-t1x9gknd 8875 12 with with IN cord-010119-t1x9gknd 8875 13 MDA MDA NNP cord-010119-t1x9gknd 8875 14 , , , cord-010119-t1x9gknd 8875 15 participated participate VBD cord-010119-t1x9gknd 8875 16 in in IN cord-010119-t1x9gknd 8875 17 the the DT cord-010119-t1x9gknd 8875 18 survey survey NN cord-010119-t1x9gknd 8875 19 , , , cord-010119-t1x9gknd 8875 20 listed list VBN cord-010119-t1x9gknd 8875 21 as as IN cord-010119-t1x9gknd 8875 22 A A NNP cord-010119-t1x9gknd 8875 23 to to IN cord-010119-t1x9gknd 8875 24 P. p. NN cord-010119-t1x9gknd 8876 1 The the DT cord-010119-t1x9gknd 8876 2 results result NNS cord-010119-t1x9gknd 8876 3 are be VBP cord-010119-t1x9gknd 8876 4 presented present VBN cord-010119-t1x9gknd 8876 5 in in IN cord-010119-t1x9gknd 8876 6 the the DT cord-010119-t1x9gknd 8876 7 table table NN cord-010119-t1x9gknd 8876 8 along along IN cord-010119-t1x9gknd 8876 9 with with IN cord-010119-t1x9gknd 8876 10 each each DT cord-010119-t1x9gknd 8876 11 hospital hospital NN cord-010119-t1x9gknd 8876 12 's 's POS cord-010119-t1x9gknd 8876 13 distance distance NN cord-010119-t1x9gknd 8876 14 from from IN cord-010119-t1x9gknd 8876 15 the the DT cord-010119-t1x9gknd 8876 16 2 2 CD cord-010119-t1x9gknd 8876 17 MDA MDA NNP cord-010119-t1x9gknd 8876 18 facilities facility NNS cord-010119-t1x9gknd 8876 19 . . . cord-010119-t1x9gknd 8877 1 For for IN cord-010119-t1x9gknd 8877 2 some some DT cord-010119-t1x9gknd 8877 3 hospitals hospital NNS cord-010119-t1x9gknd 8877 4 , , , cord-010119-t1x9gknd 8877 5 the the DT cord-010119-t1x9gknd 8877 6 sum sum NN cord-010119-t1x9gknd 8877 7 of of IN cord-010119-t1x9gknd 8877 8 transfused transfuse VBN cord-010119-t1x9gknd 8877 9 and and CC cord-010119-t1x9gknd 8877 10 wasted waste VBN cord-010119-t1x9gknd 8877 11 PLT PLT NNP cord-010119-t1x9gknd 8877 12 was be VBD cord-010119-t1x9gknd 8877 13 slightly slightly RB cord-010119-t1x9gknd 8877 14 less less JJR cord-010119-t1x9gknd 8877 15 than than IN cord-010119-t1x9gknd 8877 16 the the DT cord-010119-t1x9gknd 8877 17 number number NN cord-010119-t1x9gknd 8877 18 of of IN cord-010119-t1x9gknd 8877 19 PLT PLT NNP cord-010119-t1x9gknd 8877 20 supplied supply VBN cord-010119-t1x9gknd 8877 21 by by IN cord-010119-t1x9gknd 8877 22 MDA MDA NNP cord-010119-t1x9gknd 8877 23 ; ; : cord-010119-t1x9gknd 8877 24 this this DT cord-010119-t1x9gknd 8877 25 is be VBZ cord-010119-t1x9gknd 8877 26 likely likely JJ cord-010119-t1x9gknd 8877 27 due due IN cord-010119-t1x9gknd 8877 28 to to IN cord-010119-t1x9gknd 8877 29 the the DT cord-010119-t1x9gknd 8877 30 small small JJ cord-010119-t1x9gknd 8877 31 number number NN cord-010119-t1x9gknd 8877 32 of of IN cord-010119-t1x9gknd 8877 33 PLT PLT NNP cord-010119-t1x9gknd 8877 34 that that WDT cord-010119-t1x9gknd 8877 35 had have VBD cord-010119-t1x9gknd 8877 36 not not RB cord-010119-t1x9gknd 8877 37 either either RB cord-010119-t1x9gknd 8877 38 been be VBN cord-010119-t1x9gknd 8877 39 transfused transfuse VBN cord-010119-t1x9gknd 8877 40 or or CC cord-010119-t1x9gknd 8877 41 expired expire VBN cord-010119-t1x9gknd 8877 42 by by IN cord-010119-t1x9gknd 8877 43 the the DT cord-010119-t1x9gknd 8877 44 time time NN cord-010119-t1x9gknd 8877 45 the the DT cord-010119-t1x9gknd 8877 46 data data NN cord-010119-t1x9gknd 8877 47 collection collection NN cord-010119-t1x9gknd 8877 48 period period NN cord-010119-t1x9gknd 8877 49 ended end VBD cord-010119-t1x9gknd 8877 50 . . . cord-010119-t1x9gknd 8878 1 Three three CD cord-010119-t1x9gknd 8878 2 of of IN cord-010119-t1x9gknd 8878 3 the the DT cord-010119-t1x9gknd 8878 4 largest large JJS cord-010119-t1x9gknd 8878 5 hospitals hospital NNS cord-010119-t1x9gknd 8878 6 ( ( -LRB- cord-010119-t1x9gknd 8878 7 C C NNP cord-010119-t1x9gknd 8878 8 , , , cord-010119-t1x9gknd 8878 9 B B NNP cord-010119-t1x9gknd 8878 10 and and CC cord-010119-t1x9gknd 8878 11 A a NN cord-010119-t1x9gknd 8878 12 ) ) -RRB- cord-010119-t1x9gknd 8878 13 collected collect VBD cord-010119-t1x9gknd 8878 14 PLT PLT NNP cord-010119-t1x9gknd 8878 15 in in IN cord-010119-t1x9gknd 8878 16 - - HYPH cord-010119-t1x9gknd 8878 17 house house NN cord-010119-t1x9gknd 8878 18 in in IN cord-010119-t1x9gknd 8878 19 addition addition NN cord-010119-t1x9gknd 8878 20 to to IN cord-010119-t1x9gknd 8878 21 acquiring acquire VBG cord-010119-t1x9gknd 8878 22 units unit NNS cord-010119-t1x9gknd 8878 23 from from IN cord-010119-t1x9gknd 8878 24 MDA MDA NNP cord-010119-t1x9gknd 8878 25 . . . cord-010119-t1x9gknd 8879 1 These these DT cord-010119-t1x9gknd 8879 2 3 3 CD cord-010119-t1x9gknd 8879 3 hospitals hospital NNS cord-010119-t1x9gknd 8879 4 had have VBD cord-010119-t1x9gknd 8879 5 a a DT cord-010119-t1x9gknd 8879 6 lower low JJR cord-010119-t1x9gknd 8879 7 overall overall JJ cord-010119-t1x9gknd 8879 8 rate rate NN cord-010119-t1x9gknd 8879 9 of of IN cord-010119-t1x9gknd 8879 10 wastage wastage NN cord-010119-t1x9gknd 8879 11 including include VBG cord-010119-t1x9gknd 8879 12 their -PRON- PRP$ cord-010119-t1x9gknd 8879 13 own own JJ cord-010119-t1x9gknd 8879 14 donations donation NNS cord-010119-t1x9gknd 8879 15 than than IN cord-010119-t1x9gknd 8879 16 the the DT cord-010119-t1x9gknd 8879 17 other other JJ cord-010119-t1x9gknd 8879 18 13 13 CD cord-010119-t1x9gknd 8879 19 hospitals hospital NNS cord-010119-t1x9gknd 8879 20 that that WDT cord-010119-t1x9gknd 8879 21 did do VBD cord-010119-t1x9gknd 8879 22 not not RB cord-010119-t1x9gknd 8879 23 collect collect VB cord-010119-t1x9gknd 8879 24 in in IN cord-010119-t1x9gknd 8879 25 - - HYPH cord-010119-t1x9gknd 8879 26 house house NN cord-010119-t1x9gknd 8879 27 PLT PLT NNP cord-010119-t1x9gknd 8879 28 . . . cord-010119-t1x9gknd 8880 1 The the DT cord-010119-t1x9gknd 8880 2 other other JJ cord-010119-t1x9gknd 8880 3 13 13 CD cord-010119-t1x9gknd 8880 4 hospitals hospital NNS cord-010119-t1x9gknd 8880 5 had have VBD cord-010119-t1x9gknd 8880 6 wastage wastage NN cord-010119-t1x9gknd 8880 7 rates rate NNS cord-010119-t1x9gknd 8880 8 ranging range VBG cord-010119-t1x9gknd 8880 9 between between IN cord-010119-t1x9gknd 8880 10 9 9 CD cord-010119-t1x9gknd 8880 11 - - SYM cord-010119-t1x9gknd 8880 12 54 54 CD cord-010119-t1x9gknd 8880 13 % % NN cord-010119-t1x9gknd 8880 14 . . . cord-010119-t1x9gknd 8881 1 No no DT cord-010119-t1x9gknd 8881 2 correlation correlation NN cord-010119-t1x9gknd 8881 3 was be VBD cord-010119-t1x9gknd 8881 4 apparent apparent JJ cord-010119-t1x9gknd 8881 5 between between IN cord-010119-t1x9gknd 8881 6 the the DT cord-010119-t1x9gknd 8881 7 hospital hospital NN cord-010119-t1x9gknd 8881 8 's 's POS cord-010119-t1x9gknd 8881 9 distance distance NN cord-010119-t1x9gknd 8881 10 from from IN cord-010119-t1x9gknd 8881 11 the the DT cord-010119-t1x9gknd 8881 12 MDA MDA NNP cord-010119-t1x9gknd 8881 13 facility facility NN cord-010119-t1x9gknd 8881 14 or or CC cord-010119-t1x9gknd 8881 15 its -PRON- PRP$ cord-010119-t1x9gknd 8881 16 number number NN cord-010119-t1x9gknd 8881 17 of of IN cord-010119-t1x9gknd 8881 18 beds bed NNS cord-010119-t1x9gknd 8881 19 and and CC cord-010119-t1x9gknd 8881 20 the the DT cord-010119-t1x9gknd 8881 21 PLT PLT NNP cord-010119-t1x9gknd 8881 22 wastage wastage NN cord-010119-t1x9gknd 8881 23 rate rate NN cord-010119-t1x9gknd 8881 24 . . . cord-010119-t1x9gknd 8882 1 Conclusion conclusion NN cord-010119-t1x9gknd 8882 2 : : : cord-010119-t1x9gknd 8882 3 There there EX cord-010119-t1x9gknd 8882 4 is be VBZ cord-010119-t1x9gknd 8882 5 considerable considerable JJ cord-010119-t1x9gknd 8882 6 platelet platelet NN cord-010119-t1x9gknd 8882 7 wastage wastage NN cord-010119-t1x9gknd 8882 8 in in IN cord-010119-t1x9gknd 8882 9 Israel Israel NNP cord-010119-t1x9gknd 8882 10 . . . cord-010119-t1x9gknd 8883 1 Large large JJ cord-010119-t1x9gknd 8883 2 hospitals hospital NNS cord-010119-t1x9gknd 8883 3 in in IN cord-010119-t1x9gknd 8883 4 Israel Israel NNP cord-010119-t1x9gknd 8883 5 with with IN cord-010119-t1x9gknd 8883 6 in in IN cord-010119-t1x9gknd 8883 7 - - HYPH cord-010119-t1x9gknd 8883 8 house house NN cord-010119-t1x9gknd 8883 9 donations donation NNS cord-010119-t1x9gknd 8883 10 had have VBD cord-010119-t1x9gknd 8883 11 the the DT cord-010119-t1x9gknd 8883 12 lowest low JJS cord-010119-t1x9gknd 8883 13 overall overall JJ cord-010119-t1x9gknd 8883 14 wastage wastage NN cord-010119-t1x9gknd 8883 15 rates rate NNS cord-010119-t1x9gknd 8883 16 in in IN cord-010119-t1x9gknd 8883 17 comparison comparison NN cord-010119-t1x9gknd 8883 18 to to IN cord-010119-t1x9gknd 8883 19 the the DT cord-010119-t1x9gknd 8883 20 other other JJ cord-010119-t1x9gknd 8883 21 hospitals hospital NNS cord-010119-t1x9gknd 8883 22 . . . cord-010119-t1x9gknd 8884 1 Factors factor NNS cord-010119-t1x9gknd 8884 2 known know VBN cord-010119-t1x9gknd 8884 3 to to TO cord-010119-t1x9gknd 8884 4 affect affect VB cord-010119-t1x9gknd 8884 5 PLT PLT NNP cord-010119-t1x9gknd 8884 6 utilization utilization NN cord-010119-t1x9gknd 8884 7 and and CC cord-010119-t1x9gknd 8884 8 wastage wastage NN cord-010119-t1x9gknd 8884 9 such such JJ cord-010119-t1x9gknd 8884 10 as as IN cord-010119-t1x9gknd 8884 11 patient patient JJ cord-010119-t1x9gknd 8884 12 diagnosis diagnosis NN cord-010119-t1x9gknd 8884 13 mix mix NN cord-010119-t1x9gknd 8884 14 , , , cord-010119-t1x9gknd 8884 15 policies policy NNS cord-010119-t1x9gknd 8884 16 about about IN cord-010119-t1x9gknd 8884 17 how how WRB cord-010119-t1x9gknd 8884 18 PLT PLT NNP cord-010119-t1x9gknd 8884 19 are be VBP cord-010119-t1x9gknd 8884 20 issued issue VBN cord-010119-t1x9gknd 8884 21 and and CC cord-010119-t1x9gknd 8884 22 accepted accept VBN cord-010119-t1x9gknd 8884 23 back back RB cord-010119-t1x9gknd 8884 24 into into IN cord-010119-t1x9gknd 8884 25 hospital hospital NN cord-010119-t1x9gknd 8884 26 inventory inventory NN cord-010119-t1x9gknd 8884 27 , , , cord-010119-t1x9gknd 8884 28 PLT PLT NNP cord-010119-t1x9gknd 8884 29 inventory inventory NN cord-010119-t1x9gknd 8884 30 size size NN cord-010119-t1x9gknd 8884 31 and and CC cord-010119-t1x9gknd 8884 32 the the DT cord-010119-t1x9gknd 8884 33 time time NN cord-010119-t1x9gknd 8884 34 of of IN cord-010119-t1x9gknd 8884 35 pooling pooling NN cord-010119-t1x9gknd 8884 36 of of IN cord-010119-t1x9gknd 8884 37 whole whole JJ cord-010119-t1x9gknd 8884 38 blood blood NN cord-010119-t1x9gknd 8884 39 platelets platelet NNS cord-010119-t1x9gknd 8884 40 relative relative JJ cord-010119-t1x9gknd 8884 41 to to IN cord-010119-t1x9gknd 8884 42 the the DT cord-010119-t1x9gknd 8884 43 time time NN cord-010119-t1x9gknd 8884 44 they -PRON- PRP cord-010119-t1x9gknd 8884 45 are be VBP cord-010119-t1x9gknd 8884 46 issued issue VBN cord-010119-t1x9gknd 8884 47 and and CC cord-010119-t1x9gknd 8884 48 returned return VBN cord-010119-t1x9gknd 8884 49 to to IN cord-010119-t1x9gknd 8884 50 the the DT cord-010119-t1x9gknd 8884 51 blood blood NN cord-010119-t1x9gknd 8884 52 bank bank NN cord-010119-t1x9gknd 8884 53 need need VBP cord-010119-t1x9gknd 8884 54 to to TO cord-010119-t1x9gknd 8884 55 be be VB cord-010119-t1x9gknd 8884 56 investigated investigate VBN cord-010119-t1x9gknd 8884 57 and and CC cord-010119-t1x9gknd 8884 58 optimized optimize VBN cord-010119-t1x9gknd 8884 59 in in IN cord-010119-t1x9gknd 8884 60 order order NN cord-010119-t1x9gknd 8884 61 to to TO cord-010119-t1x9gknd 8884 62 reduce reduce VB cord-010119-t1x9gknd 8884 63 wastage wastage NN cord-010119-t1x9gknd 8884 64 rates rate NNS cord-010119-t1x9gknd 8884 65 . . . cord-010119-t1x9gknd 8885 1 Possible possible JJ cord-010119-t1x9gknd 8885 2 Immune immune NN cord-010119-t1x9gknd 8885 3 - - HYPH cord-010119-t1x9gknd 8885 4 Mediated mediate VBN cord-010119-t1x9gknd 8885 5 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 8886 1 Due due IN cord-010119-t1x9gknd 8886 2 to to IN cord-010119-t1x9gknd 8886 3 Platelet platelet NN cord-010119-t1x9gknd 8886 4 Transfusion transfusion NN cord-010119-t1x9gknd 8886 5 Masked mask VBN cord-010119-t1x9gknd 8886 6 By by IN cord-010119-t1x9gknd 8886 7 Underlying Underlying NNP cord-010119-t1x9gknd 8886 8 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 8886 9 in in IN cord-010119-t1x9gknd 8886 10 a a DT cord-010119-t1x9gknd 8886 11 Patient patient NN cord-010119-t1x9gknd 8886 12 with with IN cord-010119-t1x9gknd 8886 13 Blast Blast NNP cord-010119-t1x9gknd 8886 14 Crisis Crisis NNP cord-010119-t1x9gknd 8887 1 Sirisha Sirisha NNP cord-010119-t1x9gknd 8887 2 Kundrapu Kundrapu NNP cord-010119-t1x9gknd 8887 3 * * NFP cord-010119-t1x9gknd 8887 4 1,2 1,2 CD cord-010119-t1x9gknd 8887 5 , , , cord-010119-t1x9gknd 8887 6 Christopher Christopher NNP cord-010119-t1x9gknd 8887 7 J J NNP cord-010119-t1x9gknd 8887 8 Gresens Gresens NNP cord-010119-t1x9gknd 8887 9 3 3 CD cord-010119-t1x9gknd 8887 10 , , , cord-010119-t1x9gknd 8887 11 Anne Anne NNP cord-010119-t1x9gknd 8887 12 Capetillo Capetillo NNP cord-010119-t1x9gknd 8887 13 2 2 CD cord-010119-t1x9gknd 8887 14 , , , cord-010119-t1x9gknd 8887 15 Hollie Hollie NNP cord-010119-t1x9gknd 8887 16 M M NNP cord-010119-t1x9gknd 8887 17 Reeves Reeves NNP cord-010119-t1x9gknd 8887 18 1,2 1,2 CD cord-010119-t1x9gknd 8887 19 and and CC cord-010119-t1x9gknd 8887 20 Katharine Katharine NNP cord-010119-t1x9gknd 8887 21 A a DT cord-010119-t1x9gknd 8887 22 Downes Downes NNP cord-010119-t1x9gknd 8888 1 1,2 1,2 LS cord-010119-t1x9gknd 8888 2 . . . cord-010119-t1x9gknd 8889 1 1 1 LS cord-010119-t1x9gknd 8890 1 Case Case NNP cord-010119-t1x9gknd 8890 2 Western Western NNP cord-010119-t1x9gknd 8890 3 Reserve Reserve NNP cord-010119-t1x9gknd 8890 4 University University NNP cord-010119-t1x9gknd 8890 5 School School NNP cord-010119-t1x9gknd 8890 6 of of IN cord-010119-t1x9gknd 8890 7 Medicine Medicine NNP cord-010119-t1x9gknd 8890 8 , , , cord-010119-t1x9gknd 8890 9 2 2 CD cord-010119-t1x9gknd 8890 10 University University NNP cord-010119-t1x9gknd 8890 11 Hospitals Hospitals NNPS cord-010119-t1x9gknd 8890 12 Cleveland Cleveland NNP cord-010119-t1x9gknd 8890 13 Medical Medical NNP cord-010119-t1x9gknd 8890 14 Center Center NNP cord-010119-t1x9gknd 8890 15 , , , cord-010119-t1x9gknd 8890 16 3 3 CD cord-010119-t1x9gknd 8890 17 BloodSource BloodSource NNP cord-010119-t1x9gknd 8890 18 Background Background NNP cord-010119-t1x9gknd 8890 19 / / SYM cord-010119-t1x9gknd 8890 20 Case Case NNP cord-010119-t1x9gknd 8890 21 Studies Studies NNPS cord-010119-t1x9gknd 8890 22 : : : cord-010119-t1x9gknd 8890 23 Transfusion transfusion NN cord-010119-t1x9gknd 8890 24 - - HYPH cord-010119-t1x9gknd 8890 25 related relate VBN cord-010119-t1x9gknd 8890 26 hemolysis hemolysis NN cord-010119-t1x9gknd 8890 27 with with IN cord-010119-t1x9gknd 8890 28 ABOmismatched abomismatched JJ cord-010119-t1x9gknd 8890 29 platelets platelet NNS cord-010119-t1x9gknd 8890 30 is be VBZ cord-010119-t1x9gknd 8890 31 rare rare JJ cord-010119-t1x9gknd 8890 32 with with IN cord-010119-t1x9gknd 8890 33 a a DT cord-010119-t1x9gknd 8890 34 reported report VBN cord-010119-t1x9gknd 8890 35 incidence incidence NN cord-010119-t1x9gknd 8890 36 of of IN cord-010119-t1x9gknd 8890 37 < < NNP cord-010119-t1x9gknd 8890 38 0.1 0.1 CD cord-010119-t1x9gknd 8890 39 % % NN cord-010119-t1x9gknd 8890 40 . . . cord-010119-t1x9gknd 8891 1 Most most RBS cord-010119-t1x9gknd 8891 2 commonly commonly RB cord-010119-t1x9gknd 8891 3 in in IN cord-010119-t1x9gknd 8891 4 such such JJ cord-010119-t1x9gknd 8891 5 cases case NNS cord-010119-t1x9gknd 8891 6 Group Group NNP cord-010119-t1x9gknd 8891 7 O O NNP cord-010119-t1x9gknd 8891 8 platelets platelet NNS cord-010119-t1x9gknd 8891 9 having have VBG cord-010119-t1x9gknd 8891 10 high high JJ cord-010119-t1x9gknd 8891 11 titer titer NN cord-010119-t1x9gknd 8891 12 anti anti JJ cord-010119-t1x9gknd 8891 13 - - JJ cord-010119-t1x9gknd 8891 14 A a DT cord-010119-t1x9gknd 8891 15 result result NN cord-010119-t1x9gknd 8891 16 in in IN cord-010119-t1x9gknd 8891 17 clinically clinically RB cord-010119-t1x9gknd 8891 18 significant significant JJ cord-010119-t1x9gknd 8891 19 hemolysis hemolysis NN cord-010119-t1x9gknd 8891 20 when when WRB cord-010119-t1x9gknd 8891 21 transfused transfuse VBN cord-010119-t1x9gknd 8891 22 to to IN cord-010119-t1x9gknd 8891 23 a a DT cord-010119-t1x9gknd 8891 24 Group Group NNP cord-010119-t1x9gknd 8891 25 A A NNP cord-010119-t1x9gknd 8891 26 or or CC cord-010119-t1x9gknd 8891 27 AB AB NNP cord-010119-t1x9gknd 8891 28 recipient recipient NN cord-010119-t1x9gknd 8891 29 . . . cord-010119-t1x9gknd 8892 1 We -PRON- PRP cord-010119-t1x9gknd 8892 2 present present VBP cord-010119-t1x9gknd 8892 3 a a DT cord-010119-t1x9gknd 8892 4 patient patient NN cord-010119-t1x9gknd 8892 5 with with IN cord-010119-t1x9gknd 8892 6 a a DT cord-010119-t1x9gknd 8892 7 possible possible JJ cord-010119-t1x9gknd 8892 8 hemolytic hemolytic JJ cord-010119-t1x9gknd 8892 9 reaction reaction NN cord-010119-t1x9gknd 8892 10 following follow VBG cord-010119-t1x9gknd 8892 11 transfusion transfusion NN cord-010119-t1x9gknd 8892 12 of of IN cord-010119-t1x9gknd 8892 13 ABO ABO NNP cord-010119-t1x9gknd 8892 14 mismatched mismatch VBD cord-010119-t1x9gknd 8892 15 platelets platelet NNS cord-010119-t1x9gknd 8892 16 presenting present VBG cord-010119-t1x9gknd 8892 17 in in IN cord-010119-t1x9gknd 8892 18 the the DT cord-010119-t1x9gknd 8892 19 setting setting NN cord-010119-t1x9gknd 8892 20 of of IN cord-010119-t1x9gknd 8892 21 underlying underlie VBG cord-010119-t1x9gknd 8892 22 disease disease NN cord-010119-t1x9gknd 8892 23 associated associate VBN cord-010119-t1x9gknd 8892 24 hemolysis hemolysis NN cord-010119-t1x9gknd 8892 25 . . . cord-010119-t1x9gknd 8893 1 Study Study NNP cord-010119-t1x9gknd 8893 2 Design Design NNP cord-010119-t1x9gknd 8893 3 / / SYM cord-010119-t1x9gknd 8893 4 Method method NN cord-010119-t1x9gknd 8893 5 : : : cord-010119-t1x9gknd 8894 1 A a DT cord-010119-t1x9gknd 8894 2 58-year 58-year JJ cord-010119-t1x9gknd 8894 3 - - HYPH cord-010119-t1x9gknd 8894 4 old old JJ cord-010119-t1x9gknd 8894 5 male male NN cord-010119-t1x9gknd 8894 6 with with IN cord-010119-t1x9gknd 8894 7 chronic chronic JJ cord-010119-t1x9gknd 8894 8 myelogenous myelogenous NN cord-010119-t1x9gknd 8894 9 leukemia leukemia NN cord-010119-t1x9gknd 8894 10 in in IN cord-010119-t1x9gknd 8894 11 blast blast NN cord-010119-t1x9gknd 8894 12 crisis crisis NN cord-010119-t1x9gknd 8894 13 was be VBD cord-010119-t1x9gknd 8894 14 evaluated evaluate VBN cord-010119-t1x9gknd 8894 15 for for IN cord-010119-t1x9gknd 8894 16 possible possible JJ cord-010119-t1x9gknd 8894 17 transfusion transfusion NN cord-010119-t1x9gknd 8894 18 reaction reaction NN cord-010119-t1x9gknd 8894 19 to to IN cord-010119-t1x9gknd 8894 20 a a DT cord-010119-t1x9gknd 8894 21 single single JJ cord-010119-t1x9gknd 8894 22 donor donor NN cord-010119-t1x9gknd 8894 23 platelet platelet NN cord-010119-t1x9gknd 8894 24 ( ( -LRB- cord-010119-t1x9gknd 8894 25 SDP SDP NNP cord-010119-t1x9gknd 8894 26 ) ) -RRB- cord-010119-t1x9gknd 8894 27 . . . cord-010119-t1x9gknd 8895 1 Two two CD cord-010119-t1x9gknd 8895 2 hours hour NNS cord-010119-t1x9gknd 8895 3 post post NN cord-010119-t1x9gknd 8895 4 transfusion transfusion NN cord-010119-t1x9gknd 8895 5 he -PRON- PRP cord-010119-t1x9gknd 8895 6 developed develop VBD cord-010119-t1x9gknd 8895 7 chills chill NNS cord-010119-t1x9gknd 8895 8 , , , cord-010119-t1x9gknd 8895 9 rigors rigor NNS cord-010119-t1x9gknd 8895 10 , , , cord-010119-t1x9gknd 8895 11 and and CC cord-010119-t1x9gknd 8895 12 increased increase VBN cord-010119-t1x9gknd 8895 13 blood blood NN cord-010119-t1x9gknd 8895 14 pressure pressure NN cord-010119-t1x9gknd 8896 1 ( ( -LRB- cord-010119-t1x9gknd 8896 2 117/65 117/65 CD cord-010119-t1x9gknd 8896 3 mm mm CD cord-010119-t1x9gknd 8896 4 Hg Hg NNP cord-010119-t1x9gknd 8896 5 to to IN cord-010119-t1x9gknd 8896 6 205/89 205/89 CD cord-010119-t1x9gknd 8896 7 mm mm CD cord-010119-t1x9gknd 8896 8 Hg Hg NNP cord-010119-t1x9gknd 8896 9 ) ) -RRB- cord-010119-t1x9gknd 8896 10 followed follow VBN cord-010119-t1x9gknd 8896 11 by by IN cord-010119-t1x9gknd 8896 12 hematuria hematuria NN cord-010119-t1x9gknd 8896 13 ( ( -LRB- cord-010119-t1x9gknd 8896 14 500 500 CD cord-010119-t1x9gknd 8896 15 mL ml NN cord-010119-t1x9gknd 8896 16 ) ) -RRB- cord-010119-t1x9gknd 8896 17 . . . cord-010119-t1x9gknd 8897 1 Chills chill NNS cord-010119-t1x9gknd 8897 2 and and CC cord-010119-t1x9gknd 8897 3 rigors rigor NNS cord-010119-t1x9gknd 8897 4 resolved resolve VBN cord-010119-t1x9gknd 8897 5 ; ; : cord-010119-t1x9gknd 8897 6 blood blood NN cord-010119-t1x9gknd 8897 7 pressure pressure NN cord-010119-t1x9gknd 8897 8 stabilized stabilize VBN cord-010119-t1x9gknd 8897 9 after after IN cord-010119-t1x9gknd 8897 10 15 15 CD cord-010119-t1x9gknd 8897 11 min min NN cord-010119-t1x9gknd 8897 12 with with IN cord-010119-t1x9gknd 8897 13 diphenhydramine diphenhydramine NN cord-010119-t1x9gknd 8897 14 , , , cord-010119-t1x9gknd 8897 15 solumedrol solumedrol NN cord-010119-t1x9gknd 8897 16 , , , cord-010119-t1x9gknd 8897 17 and and CC cord-010119-t1x9gknd 8897 18 acetaminophen acetaminophen NN cord-010119-t1x9gknd 8897 19 . . . cord-010119-t1x9gknd 8898 1 negative negative JJ cord-010119-t1x9gknd 8898 2 . . . cord-010119-t1x9gknd 8899 1 Patient Patient NNP cord-010119-t1x9gknd 8899 2 ABO ABO NNP cord-010119-t1x9gknd 8899 3 group group NN cord-010119-t1x9gknd 8899 4 , , , cord-010119-t1x9gknd 8899 5 Rh Rh NNP cord-010119-t1x9gknd 8899 6 ( ( -LRB- cord-010119-t1x9gknd 8899 7 D D NNP cord-010119-t1x9gknd 8899 8 ) ) -RRB- cord-010119-t1x9gknd 8899 9 type type NN cord-010119-t1x9gknd 8899 10 and and CC cord-010119-t1x9gknd 8899 11 antibody antibody NN cord-010119-t1x9gknd 8899 12 screen screen NN cord-010119-t1x9gknd 8899 13 on on IN cord-010119-t1x9gknd 8899 14 pre pre JJ cord-010119-t1x9gknd 8899 15 - - JJ cord-010119-t1x9gknd 8899 16 and and CC cord-010119-t1x9gknd 8899 17 post post JJ cord-010119-t1x9gknd 8899 18 - - JJ cord-010119-t1x9gknd 8899 19 transfusion transfusion JJ cord-010119-t1x9gknd 8899 20 specimens specimen NNS cord-010119-t1x9gknd 8899 21 showed show VBD cord-010119-t1x9gknd 8899 22 no no DT cord-010119-t1x9gknd 8899 23 discrepancies discrepancy NNS cord-010119-t1x9gknd 8899 24 . . . cord-010119-t1x9gknd 8900 1 Laboratory laboratory NN cord-010119-t1x9gknd 8900 2 indicators indicator NNS cord-010119-t1x9gknd 8900 3 of of IN cord-010119-t1x9gknd 8900 4 hemolysis hemolysis NN cord-010119-t1x9gknd 8900 5 are be VBP cord-010119-t1x9gknd 8900 6 summarized summarize VBN cord-010119-t1x9gknd 8900 7 in in IN cord-010119-t1x9gknd 8900 8 Table Table NNP cord-010119-t1x9gknd 8900 9 . . . cord-010119-t1x9gknd 8901 1 Notably notably RB cord-010119-t1x9gknd 8901 2 , , , cord-010119-t1x9gknd 8901 3 while while IN cord-010119-t1x9gknd 8901 4 total/ total/ CD cord-010119-t1x9gknd 8901 5 indirect indirect JJ cord-010119-t1x9gknd 8901 6 bilirubin bilirubin NN cord-010119-t1x9gknd 8901 7 increased increase VBD cord-010119-t1x9gknd 8901 8 and and CC cord-010119-t1x9gknd 8901 9 hemoglobin hemoglobin NN cord-010119-t1x9gknd 8901 10 decreased decrease VBD cord-010119-t1x9gknd 8901 11 after after IN cord-010119-t1x9gknd 8901 12 transfusion transfusion NN cord-010119-t1x9gknd 8901 13 other other JJ cord-010119-t1x9gknd 8901 14 tests test NNS cord-010119-t1x9gknd 8901 15 were be VBD cord-010119-t1x9gknd 8901 16 indeterminate indeterminate JJ cord-010119-t1x9gknd 8901 17 for for IN cord-010119-t1x9gknd 8901 18 hemolytic hemolytic JJ cord-010119-t1x9gknd 8901 19 transfusion transfusion NN cord-010119-t1x9gknd 8901 20 reaction reaction NN cord-010119-t1x9gknd 8901 21 with with IN cord-010119-t1x9gknd 8901 22 abnormal abnormal JJ cord-010119-t1x9gknd 8901 23 pretransfusion pretransfusion NN cord-010119-t1x9gknd 8901 24 levels level NNS cord-010119-t1x9gknd 8901 25 . . . cord-010119-t1x9gknd 8902 1 Despite despite IN cord-010119-t1x9gknd 8902 2 underlying underlying JJ cord-010119-t1x9gknd 8902 3 disease disease NN cord-010119-t1x9gknd 8902 4 associated associate VBN cord-010119-t1x9gknd 8902 5 hemolysis hemolysis NN cord-010119-t1x9gknd 8902 6 , , , cord-010119-t1x9gknd 8902 7 the the DT cord-010119-t1x9gknd 8902 8 blood blood NN cord-010119-t1x9gknd 8902 9 supplier supplier NN cord-010119-t1x9gknd 8902 10 of of IN cord-010119-t1x9gknd 8902 11 the the DT cord-010119-t1x9gknd 8902 12 unit unit NN cord-010119-t1x9gknd 8902 13 was be VBD cord-010119-t1x9gknd 8902 14 contacted contact VBN cord-010119-t1x9gknd 8902 15 to to TO cord-010119-t1x9gknd 8902 16 investigate investigate VB cord-010119-t1x9gknd 8902 17 into into IN cord-010119-t1x9gknd 8902 18 the the DT cord-010119-t1x9gknd 8902 19 possibility possibility NN cord-010119-t1x9gknd 8902 20 of of IN cord-010119-t1x9gknd 8902 21 high high JJ cord-010119-t1x9gknd 8902 22 titer titer NN cord-010119-t1x9gknd 8902 23 donor donor NN cord-010119-t1x9gknd 8903 1 anti anti JJ cord-010119-t1x9gknd 8903 2 - - NN cord-010119-t1x9gknd 8903 3 A. a. JJ cord-010119-t1x9gknd 8903 4 This this DT cord-010119-t1x9gknd 8903 5 revealed reveal VBD cord-010119-t1x9gknd 8903 6 donor donor NN cord-010119-t1x9gknd 8903 7 anti anti JJ cord-010119-t1x9gknd 8903 8 - - JJ cord-010119-t1x9gknd 8903 9 A a DT cord-010119-t1x9gknd 8903 10 titer titer NN cord-010119-t1x9gknd 8903 11 results result NNS cord-010119-t1x9gknd 8903 12 of of IN cord-010119-t1x9gknd 8903 13 256 256 CD cord-010119-t1x9gknd 8903 14 ( ( -LRB- cord-010119-t1x9gknd 8903 15 IgM IgM NNP cord-010119-t1x9gknd 8903 16 ) ) -RRB- cord-010119-t1x9gknd 8903 17 and and CC cord-010119-t1x9gknd 8903 18 1,024 1,024 CD cord-010119-t1x9gknd 8903 19 ( ( -LRB- cord-010119-t1x9gknd 8903 20 IgG IgG NNP cord-010119-t1x9gknd 8903 21 ) ) -RRB- cord-010119-t1x9gknd 8903 22 ; ; : cord-010119-t1x9gknd 8903 23 donor donor NN cord-010119-t1x9gknd 8903 24 was be VBD cord-010119-t1x9gknd 8903 25 deferred defer VBN cord-010119-t1x9gknd 8903 26 from from IN cord-010119-t1x9gknd 8903 27 future future JJ cord-010119-t1x9gknd 8903 28 platelet platelet NN cord-010119-t1x9gknd 8903 29 donations donation NNS cord-010119-t1x9gknd 8903 30 . . . cord-010119-t1x9gknd 8904 1 Conclusion conclusion NN cord-010119-t1x9gknd 8904 2 : : : cord-010119-t1x9gknd 8904 3 While while IN cord-010119-t1x9gknd 8904 4 the the DT cord-010119-t1x9gknd 8904 5 post post JJ cord-010119-t1x9gknd 8904 6 - - JJ cord-010119-t1x9gknd 8904 7 transfusion transfusion JJ cord-010119-t1x9gknd 8904 8 sample sample NN cord-010119-t1x9gknd 8904 9 had have VBD cord-010119-t1x9gknd 8904 10 no no DT cord-010119-t1x9gknd 8904 11 visible visible JJ cord-010119-t1x9gknd 8904 12 hemolysis hemolysis NN cord-010119-t1x9gknd 8904 13 and and CC cord-010119-t1x9gknd 8904 14 a a DT cord-010119-t1x9gknd 8904 15 negative negative JJ cord-010119-t1x9gknd 8904 16 DAT dat NN cord-010119-t1x9gknd 8904 17 , , , cord-010119-t1x9gknd 8904 18 increased increase VBN cord-010119-t1x9gknd 8904 19 total/ total/ CD cord-010119-t1x9gknd 8904 20 indirect indirect JJ cord-010119-t1x9gknd 8904 21 bilirubin bilirubin NN cord-010119-t1x9gknd 8904 22 after after IN cord-010119-t1x9gknd 8904 23 transfusion transfusion NN cord-010119-t1x9gknd 8904 24 and and CC cord-010119-t1x9gknd 8904 25 high high JJ cord-010119-t1x9gknd 8904 26 titer titer NN cord-010119-t1x9gknd 8904 27 donor donor NN cord-010119-t1x9gknd 8904 28 anti anti NNP cord-010119-t1x9gknd 8904 29 - - NNP cord-010119-t1x9gknd 8904 30 A A NNP cord-010119-t1x9gknd 8904 31 are be VBP cord-010119-t1x9gknd 8904 32 supportive supportive JJ cord-010119-t1x9gknd 8904 33 of of IN cord-010119-t1x9gknd 8904 34 immune immune JJ cord-010119-t1x9gknd 8904 35 mediated mediate VBN cord-010119-t1x9gknd 8904 36 hemolytic hemolytic JJ cord-010119-t1x9gknd 8904 37 transfusion transfusion NN cord-010119-t1x9gknd 8904 38 reaction reaction NN cord-010119-t1x9gknd 8904 39 . . . cord-010119-t1x9gknd 8905 1 The the DT cord-010119-t1x9gknd 8905 2 key key JJ cord-010119-t1x9gknd 8905 3 unique unique JJ cord-010119-t1x9gknd 8905 4 aspect aspect NN cord-010119-t1x9gknd 8905 5 in in IN cord-010119-t1x9gknd 8905 6 this this DT cord-010119-t1x9gknd 8905 7 case case NN cord-010119-t1x9gknd 8905 8 is be VBZ cord-010119-t1x9gknd 8905 9 baseline baseline JJ cord-010119-t1x9gknd 8905 10 underlying underlying JJ cord-010119-t1x9gknd 8905 11 hemolysis hemolysis NN cord-010119-t1x9gknd 8905 12 , , , cord-010119-t1x9gknd 8905 13 which which WDT cord-010119-t1x9gknd 8905 14 may may MD cord-010119-t1x9gknd 8905 15 mask mask VB cord-010119-t1x9gknd 8905 16 needs need NNS cord-010119-t1x9gknd 8905 17 for for IN cord-010119-t1x9gknd 8905 18 further further JJ cord-010119-t1x9gknd 8905 19 investigation investigation NN cord-010119-t1x9gknd 8905 20 of of IN cord-010119-t1x9gknd 8905 21 donor donor NN cord-010119-t1x9gknd 8905 22 for for IN cord-010119-t1x9gknd 8905 23 high high JJ cord-010119-t1x9gknd 8905 24 titer titer NN cord-010119-t1x9gknd 8905 25 anti anti JJ cord-010119-t1x9gknd 8905 26 - - JJ cord-010119-t1x9gknd 8905 27 A. a. JJ cord-010119-t1x9gknd 8905 28 Ana Ana NNP cord-010119-t1x9gknd 8905 29 Paula Paula NNP cord-010119-t1x9gknd 8905 30 Hitomi Hitomi NNP cord-010119-t1x9gknd 8905 31 Yokoyama Yokoyama NNP cord-010119-t1x9gknd 8905 32 * * NFP cord-010119-t1x9gknd 8905 33 1 1 CD cord-010119-t1x9gknd 8905 34 , , , cord-010119-t1x9gknd 8905 35 Leila Leila NNP cord-010119-t1x9gknd 8905 36 Patricia Patricia NNP cord-010119-t1x9gknd 8905 37 de de NNP cord-010119-t1x9gknd 8905 38 Sousa Sousa NNP cord-010119-t1x9gknd 8905 39 Fontenele Fontenele NNP cord-010119-t1x9gknd 8905 40 1 1 CD cord-010119-t1x9gknd 8905 41 , , , cord-010119-t1x9gknd 8905 42 Isabel Isabel NNP cord-010119-t1x9gknd 8905 43 Nagle Nagle NNP cord-010119-t1x9gknd 8905 44 Reis Reis NNP cord-010119-t1x9gknd 8905 45 1 1 CD cord-010119-t1x9gknd 8905 46 , , , cord-010119-t1x9gknd 8905 47 Carolina Carolina NNP cord-010119-t1x9gknd 8905 48 Bonet Bonet NNP cord-010119-t1x9gknd 8905 49 Bub Bub NNP cord-010119-t1x9gknd 8905 50 1 1 CD cord-010119-t1x9gknd 8905 51 , , , cord-010119-t1x9gknd 8905 52 Araci Araci NNP cord-010119-t1x9gknd 8905 53 Sakashita Sakashita NNP cord-010119-t1x9gknd 8905 54 1 1 CD cord-010119-t1x9gknd 8905 55 , , , cord-010119-t1x9gknd 8905 56 Raffael Raffael NNP cord-010119-t1x9gknd 8905 57 Zamper Zamper NNP cord-010119-t1x9gknd 8905 58 1 1 CD cord-010119-t1x9gknd 8905 59 , , , cord-010119-t1x9gknd 8905 60 Cristiane Cristiane NNP cord-010119-t1x9gknd 8905 61 Nakazawa Nakazawa NNP cord-010119-t1x9gknd 8905 62 1 1 CD cord-010119-t1x9gknd 8905 63 , , , cord-010119-t1x9gknd 8905 64 Tatiane Tatiane NNP cord-010119-t1x9gknd 8905 65 Almeida Almeida NNP cord-010119-t1x9gknd 8905 66 Omura Omura NNP cord-010119-t1x9gknd 8905 67 Paula Paula NNP cord-010119-t1x9gknd 8905 68 1 1 CD cord-010119-t1x9gknd 8905 69 , , , cord-010119-t1x9gknd 8905 70 Patricia Patricia NNP cord-010119-t1x9gknd 8905 71 Silva Silva NNP cord-010119-t1x9gknd 8905 72 Batista Batista NNP cord-010119-t1x9gknd 8905 73 1 1 CD cord-010119-t1x9gknd 8905 74 , , , cord-010119-t1x9gknd 8905 75 Marcio Marcio NNP cord-010119-t1x9gknd 8905 76 Dias Dias NNP cord-010119-t1x9gknd 8905 77 Almeida Almeida NNP cord-010119-t1x9gknd 8905 78 1 1 CD cord-010119-t1x9gknd 8905 79 , , , cord-010119-t1x9gknd 8905 80 Fernanda Fernanda NNP cord-010119-t1x9gknd 8905 81 Loureiro Loureiro NNP cord-010119-t1x9gknd 8905 82 de de NNP cord-010119-t1x9gknd 8905 83 Andrade Andrade NNP cord-010119-t1x9gknd 8905 84 Orsi Orsi NNP cord-010119-t1x9gknd 8905 85 2 2 CD cord-010119-t1x9gknd 8905 86 and and CC cord-010119-t1x9gknd 8905 87 Jose Jose NNP cord-010119-t1x9gknd 8905 88 Mauro Mauro NNP cord-010119-t1x9gknd 8905 89 Kutner Kutner NNP cord-010119-t1x9gknd 8906 1 1 1 LS cord-010119-t1x9gknd 8906 2 . . . cord-010119-t1x9gknd 8907 1 1 1 CD cord-010119-t1x9gknd 8907 2 Hospital Hospital NNP cord-010119-t1x9gknd 8907 3 Israelita Israelita NNP cord-010119-t1x9gknd 8907 4 Albert Albert NNP cord-010119-t1x9gknd 8907 5 Einstein Einstein NNP cord-010119-t1x9gknd 8907 6 , , , cord-010119-t1x9gknd 8907 7 2 2 CD cord-010119-t1x9gknd 8907 8 Hemocentro Hemocentro NNP cord-010119-t1x9gknd 8907 9 Unicamp Unicamp NNP cord-010119-t1x9gknd 8907 10 - - HYPH cord-010119-t1x9gknd 8907 11 Universidade Universidade NNP cord-010119-t1x9gknd 8907 12 Estadual Estadual NNP cord-010119-t1x9gknd 8907 13 de de NNP cord-010119-t1x9gknd 8907 14 Campinas Campinas NNP cord-010119-t1x9gknd 8907 15 Background Background NNP cord-010119-t1x9gknd 8907 16 / / SYM cord-010119-t1x9gknd 8907 17 Case Case NNP cord-010119-t1x9gknd 8907 18 Studies Studies NNPS cord-010119-t1x9gknd 8907 19 : : : cord-010119-t1x9gknd 8907 20 Orthotopic Orthotopic NNP cord-010119-t1x9gknd 8907 21 liver liver NN cord-010119-t1x9gknd 8907 22 transplantation transplantation NN cord-010119-t1x9gknd 8907 23 ( ( -LRB- cord-010119-t1x9gknd 8907 24 OLT OLT NNP cord-010119-t1x9gknd 8907 25 ) ) -RRB- cord-010119-t1x9gknd 8907 26 is be VBZ cord-010119-t1x9gknd 8907 27 a a DT cord-010119-t1x9gknd 8907 28 high high JJ cord-010119-t1x9gknd 8907 29 complex complex JJ cord-010119-t1x9gknd 8907 30 procedure procedure NN cord-010119-t1x9gknd 8907 31 , , , cord-010119-t1x9gknd 8907 32 fundamental fundamental JJ cord-010119-t1x9gknd 8907 33 to to IN cord-010119-t1x9gknd 8907 34 therapeutic therapeutic JJ cord-010119-t1x9gknd 8907 35 approach approach NN cord-010119-t1x9gknd 8907 36 for for IN cord-010119-t1x9gknd 8907 37 end end NN cord-010119-t1x9gknd 8907 38 - - HYPH cord-010119-t1x9gknd 8907 39 stage stage NN cord-010119-t1x9gknd 8907 40 liver liver NN cord-010119-t1x9gknd 8907 41 disease disease NN cord-010119-t1x9gknd 8907 42 . . . cord-010119-t1x9gknd 8908 1 Despite despite IN cord-010119-t1x9gknd 8908 2 improvements improvement NNS cord-010119-t1x9gknd 8908 3 in in IN cord-010119-t1x9gknd 8908 4 hemostatic hemostatic JJ cord-010119-t1x9gknd 8908 5 , , , cord-010119-t1x9gknd 8908 6 surgical surgical JJ cord-010119-t1x9gknd 8908 7 , , , cord-010119-t1x9gknd 8908 8 and and CC cord-010119-t1x9gknd 8908 9 anaesthetic anaesthetic JJ cord-010119-t1x9gknd 8908 10 techniques technique NNS cord-010119-t1x9gknd 8908 11 , , , cord-010119-t1x9gknd 8908 12 liver liver NN cord-010119-t1x9gknd 8908 13 transplantation transplantation NN cord-010119-t1x9gknd 8908 14 is be VBZ cord-010119-t1x9gknd 8908 15 still still RB cord-010119-t1x9gknd 8908 16 associated associate VBN cord-010119-t1x9gknd 8908 17 with with IN cord-010119-t1x9gknd 8908 18 massive massive JJ cord-010119-t1x9gknd 8908 19 blood blood NN cord-010119-t1x9gknd 8908 20 loss loss NN cord-010119-t1x9gknd 8908 21 and and CC cord-010119-t1x9gknd 8908 22 high high JJ cord-010119-t1x9gknd 8908 23 rates rate NNS cord-010119-t1x9gknd 8908 24 of of IN cord-010119-t1x9gknd 8908 25 transfusion transfusion NN cord-010119-t1x9gknd 8908 26 requirements requirement NNS cord-010119-t1x9gknd 8908 27 . . . cord-010119-t1x9gknd 8909 1 Peri peri JJ cord-010119-t1x9gknd 8909 2 and and CC cord-010119-t1x9gknd 8909 3 intraoperative intraoperative JJ cord-010119-t1x9gknd 8909 4 transfusion transfusion NN cord-010119-t1x9gknd 8909 5 of of IN cord-010119-t1x9gknd 8909 6 red red JJ cord-010119-t1x9gknd 8909 7 blood blood NN cord-010119-t1x9gknd 8909 8 cells cell NNS cord-010119-t1x9gknd 8909 9 ( ( -LRB- cord-010119-t1x9gknd 8909 10 RBC RBC NNP cord-010119-t1x9gknd 8909 11 ) ) -RRB- cord-010119-t1x9gknd 8909 12 have have VBP cord-010119-t1x9gknd 8909 13 been be VBN cord-010119-t1x9gknd 8909 14 previously previously RB cord-010119-t1x9gknd 8909 15 reported report VBN cord-010119-t1x9gknd 8909 16 as as IN cord-010119-t1x9gknd 8909 17 major major JJ cord-010119-t1x9gknd 8909 18 predictors predictor NNS cord-010119-t1x9gknd 8909 19 of of IN cord-010119-t1x9gknd 8909 20 post post JJ cord-010119-t1x9gknd 8909 21 -operative -operative JJ cord-010119-t1x9gknd 8909 22 mortality mortality NN cord-010119-t1x9gknd 8909 23 . . . cord-010119-t1x9gknd 8910 1 Identifying identify VBG cord-010119-t1x9gknd 8910 2 predictive predictive JJ cord-010119-t1x9gknd 8910 3 factors factor NNS cord-010119-t1x9gknd 8910 4 for for IN cord-010119-t1x9gknd 8910 5 transfusion transfusion NN cord-010119-t1x9gknd 8910 6 requirements requirement NNS cord-010119-t1x9gknd 8910 7 may may MD cord-010119-t1x9gknd 8910 8 help help VB cord-010119-t1x9gknd 8910 9 optimise optimise VB cord-010119-t1x9gknd 8910 10 patient patient JJ cord-010119-t1x9gknd 8910 11 blood blood NN cord-010119-t1x9gknd 8910 12 management management NN cord-010119-t1x9gknd 8910 13 strategies strategy NNS cord-010119-t1x9gknd 8910 14 in in IN cord-010119-t1x9gknd 8910 15 OLT OLT NNP cord-010119-t1x9gknd 8910 16 . . . cord-010119-t1x9gknd 8911 1 We -PRON- PRP cord-010119-t1x9gknd 8911 2 conducted conduct VBD cord-010119-t1x9gknd 8911 3 a a DT cord-010119-t1x9gknd 8911 4 single single JJ cord-010119-t1x9gknd 8911 5 center center NN cord-010119-t1x9gknd 8911 6 retrospective retrospective JJ cord-010119-t1x9gknd 8911 7 analysis analysis NN cord-010119-t1x9gknd 8911 8 of of IN cord-010119-t1x9gknd 8911 9 671 671 CD cord-010119-t1x9gknd 8911 10 cases case NNS cord-010119-t1x9gknd 8911 11 of of IN cord-010119-t1x9gknd 8911 12 OLT OLT NNP cord-010119-t1x9gknd 8911 13 performed perform VBN cord-010119-t1x9gknd 8911 14 between between IN cord-010119-t1x9gknd 8911 15 2011 2011 CD cord-010119-t1x9gknd 8911 16 and and CC cord-010119-t1x9gknd 8911 17 2015 2015 CD cord-010119-t1x9gknd 8911 18 in in IN cord-010119-t1x9gknd 8911 19 Brazil Brazil NNP cord-010119-t1x9gknd 8911 20 in in IN cord-010119-t1x9gknd 8911 21 order order NN cord-010119-t1x9gknd 8911 22 to to TO cord-010119-t1x9gknd 8911 23 identify identify VB cord-010119-t1x9gknd 8911 24 predictive predictive JJ cord-010119-t1x9gknd 8911 25 factors factor NNS cord-010119-t1x9gknd 8911 26 for for IN cord-010119-t1x9gknd 8911 27 red red JJ cord-010119-t1x9gknd 8911 28 blood blood NN cord-010119-t1x9gknd 8911 29 cell cell NN cord-010119-t1x9gknd 8911 30 transfusion transfusion NN cord-010119-t1x9gknd 8911 31 Study Study NNP cord-010119-t1x9gknd 8911 32 Design Design NNP cord-010119-t1x9gknd 8911 33 / / SYM cord-010119-t1x9gknd 8911 34 Method method NN cord-010119-t1x9gknd 8911 35 : : : cord-010119-t1x9gknd 8911 36 A a DT cord-010119-t1x9gknd 8911 37 retrospective retrospective JJ cord-010119-t1x9gknd 8911 38 analysis analysis NN cord-010119-t1x9gknd 8911 39 in in IN cord-010119-t1x9gknd 8911 40 a a DT cord-010119-t1x9gknd 8911 41 single single JJ cord-010119-t1x9gknd 8911 42 institution institution NN cord-010119-t1x9gknd 8911 43 was be VBD cord-010119-t1x9gknd 8911 44 performed perform VBN cord-010119-t1x9gknd 8911 45 , , , cord-010119-t1x9gknd 8911 46 and and CC cord-010119-t1x9gknd 8911 47 charts chart NNS cord-010119-t1x9gknd 8911 48 of of IN cord-010119-t1x9gknd 8911 49 671 671 CD cord-010119-t1x9gknd 8911 50 consecutive consecutive JJ cord-010119-t1x9gknd 8911 51 patients patient NNS cord-010119-t1x9gknd 8911 52 submitted submit VBN cord-010119-t1x9gknd 8911 53 to to IN cord-010119-t1x9gknd 8911 54 liver liver NN cord-010119-t1x9gknd 8911 55 transplantation transplantation NN cord-010119-t1x9gknd 8911 56 between between IN cord-010119-t1x9gknd 8911 57 2011 2011 CD cord-010119-t1x9gknd 8911 58 and and CC cord-010119-t1x9gknd 8911 59 2016 2016 CD cord-010119-t1x9gknd 8911 60 were be VBD cord-010119-t1x9gknd 8911 61 reviewed review VBN cord-010119-t1x9gknd 8911 62 . . . cord-010119-t1x9gknd 8912 1 The the DT cord-010119-t1x9gknd 8912 2 following follow VBG cord-010119-t1x9gknd 8912 3 variables variable NNS cord-010119-t1x9gknd 8912 4 were be VBD cord-010119-t1x9gknd 8912 5 collected collect VBN cord-010119-t1x9gknd 8912 6 for for IN cord-010119-t1x9gknd 8912 7 each each DT cord-010119-t1x9gknd 8912 8 patient patient NN cord-010119-t1x9gknd 8912 9 : : : cord-010119-t1x9gknd 8912 10 gender gender NN cord-010119-t1x9gknd 8912 11 , , , cord-010119-t1x9gknd 8912 12 race race NN cord-010119-t1x9gknd 8912 13 , , , cord-010119-t1x9gknd 8912 14 primary primary JJ cord-010119-t1x9gknd 8912 15 diagnosis diagnosis NN cord-010119-t1x9gknd 8912 16 , , , cord-010119-t1x9gknd 8912 17 presence presence NN cord-010119-t1x9gknd 8912 18 of of IN cord-010119-t1x9gknd 8912 19 hepatocellular hepatocellular JJ cord-010119-t1x9gknd 8912 20 carcinoma carcinoma NN cord-010119-t1x9gknd 8912 21 , , , cord-010119-t1x9gknd 8912 22 age age NN cord-010119-t1x9gknd 8912 23 , , , cord-010119-t1x9gknd 8912 24 body body NN cord-010119-t1x9gknd 8912 25 mass mass NN cord-010119-t1x9gknd 8912 26 index index NN cord-010119-t1x9gknd 8912 27 , , , cord-010119-t1x9gknd 8912 28 corrected correct VBD cord-010119-t1x9gknd 8912 29 model model NN cord-010119-t1x9gknd 8912 30 for for IN cord-010119-t1x9gknd 8912 31 end end JJ cord-010119-t1x9gknd 8912 32 - - HYPH cord-010119-t1x9gknd 8912 33 stage stage NN cord-010119-t1x9gknd 8912 34 liver liver NN cord-010119-t1x9gknd 8912 35 disease disease NN cord-010119-t1x9gknd 8912 36 ( ( -LRB- cord-010119-t1x9gknd 8912 37 MELD MELD NNP cord-010119-t1x9gknd 8912 38 ) ) -RRB- cord-010119-t1x9gknd 8912 39 , , , cord-010119-t1x9gknd 8912 40 duration duration NN cord-010119-t1x9gknd 8912 41 of of IN cord-010119-t1x9gknd 8912 42 warm warm JJ cord-010119-t1x9gknd 8912 43 and and CC cord-010119-t1x9gknd 8912 44 cold cold JJ cord-010119-t1x9gknd 8912 45 ischemia ischemia NN cord-010119-t1x9gknd 8912 46 . . . cord-010119-t1x9gknd 8913 1 Categorical categorical JJ cord-010119-t1x9gknd 8913 2 variables variable NNS cord-010119-t1x9gknd 8913 3 were be VBD cord-010119-t1x9gknd 8913 4 analysed analyse VBN cord-010119-t1x9gknd 8913 5 using use VBG cord-010119-t1x9gknd 8913 6 Pearson Pearson NNP cord-010119-t1x9gknd 8913 7 chi chi NNP cord-010119-t1x9gknd 8913 8 - - HYPH cord-010119-t1x9gknd 8913 9 square square JJ cord-010119-t1x9gknd 8913 10 test test NN cord-010119-t1x9gknd 8913 11 . . . cord-010119-t1x9gknd 8914 1 Continuous continuous JJ cord-010119-t1x9gknd 8914 2 variables variable NNS cord-010119-t1x9gknd 8914 3 were be VBD cord-010119-t1x9gknd 8914 4 analysed analyse VBN cord-010119-t1x9gknd 8914 5 using use VBG cord-010119-t1x9gknd 8914 6 t t NN cord-010119-t1x9gknd 8914 7 - - HYPH cord-010119-t1x9gknd 8914 8 Student Student NNP cord-010119-t1x9gknd 8914 9 test test NN cord-010119-t1x9gknd 8914 10 . . . cord-010119-t1x9gknd 8915 1 A a DT cord-010119-t1x9gknd 8915 2 forward forward JJ cord-010119-t1x9gknd 8915 3 logistic logistic JJ cord-010119-t1x9gknd 8915 4 regression regression NN cord-010119-t1x9gknd 8915 5 model model NN cord-010119-t1x9gknd 8915 6 was be VBD cord-010119-t1x9gknd 8915 7 used use VBN cord-010119-t1x9gknd 8915 8 to to TO cord-010119-t1x9gknd 8915 9 analyse analyse VB cord-010119-t1x9gknd 8915 10 data datum NNS cord-010119-t1x9gknd 8915 11 in in IN cord-010119-t1x9gknd 8915 12 a a DT cord-010119-t1x9gknd 8915 13 multivariate multivariate JJ cord-010119-t1x9gknd 8915 14 fashion fashion NN cord-010119-t1x9gknd 8915 15 , , , cord-010119-t1x9gknd 8915 16 to to TO cord-010119-t1x9gknd 8915 17 identify identify VB cord-010119-t1x9gknd 8915 18 independent independent JJ cord-010119-t1x9gknd 8915 19 contribution contribution NN cord-010119-t1x9gknd 8915 20 of of IN cord-010119-t1x9gknd 8915 21 variables variable NNS cord-010119-t1x9gknd 8915 22 previously previously RB cord-010119-t1x9gknd 8915 23 found find VBN cord-010119-t1x9gknd 8915 24 to to TO cord-010119-t1x9gknd 8915 25 be be VB cord-010119-t1x9gknd 8915 26 significant significant JJ cord-010119-t1x9gknd 8915 27 . . . cord-010119-t1x9gknd 8916 1 Results result NNS cord-010119-t1x9gknd 8917 1 /Finding /finde VBG cord-010119-t1x9gknd 8917 2 : : : cord-010119-t1x9gknd 8918 1 In in IN cord-010119-t1x9gknd 8918 2 univariate univariate JJ cord-010119-t1x9gknd 8918 3 analysis analysis NN cord-010119-t1x9gknd 8918 4 , , , cord-010119-t1x9gknd 8918 5 female female JJ cord-010119-t1x9gknd 8918 6 patients patient NNS cord-010119-t1x9gknd 8918 7 , , , cord-010119-t1x9gknd 8918 8 absence absence NN cord-010119-t1x9gknd 8918 9 of of IN cord-010119-t1x9gknd 8918 10 hepatocellular hepatocellular JJ cord-010119-t1x9gknd 8918 11 carcinoma carcinoma NN cord-010119-t1x9gknd 8918 12 ( ( -LRB- cord-010119-t1x9gknd 8918 13 HCC HCC NNP cord-010119-t1x9gknd 8918 14 ) ) -RRB- cord-010119-t1x9gknd 8918 15 , , , cord-010119-t1x9gknd 8918 16 primary primary JJ cord-010119-t1x9gknd 8918 17 diagnosis diagnosis NN cord-010119-t1x9gknd 8918 18 , , , cord-010119-t1x9gknd 8918 19 corrected correct VBD cord-010119-t1x9gknd 8918 20 MELD MELD NNP cord-010119-t1x9gknd 8918 21 and and CC cord-010119-t1x9gknd 8918 22 warm warm JJ cord-010119-t1x9gknd 8918 23 ischemia ischemia NN cord-010119-t1x9gknd 8918 24 time time NN cord-010119-t1x9gknd 8918 25 were be VBD cord-010119-t1x9gknd 8918 26 significantly significantly RB cord-010119-t1x9gknd 8918 27 associated associate VBN cord-010119-t1x9gknd 8918 28 with with IN cord-010119-t1x9gknd 8918 29 consumption consumption NN cord-010119-t1x9gknd 8918 30 of of IN cord-010119-t1x9gknd 8918 31 RBC RBC NNP cord-010119-t1x9gknd 8918 32 use use NN cord-010119-t1x9gknd 8918 33 in in IN cord-010119-t1x9gknd 8918 34 the the DT cord-010119-t1x9gknd 8918 35 intraoperative intraoperative JJ cord-010119-t1x9gknd 8918 36 period period NN cord-010119-t1x9gknd 8918 37 . . . cord-010119-t1x9gknd 8919 1 Multivariate multivariate JJ cord-010119-t1x9gknd 8919 2 logistic logistic JJ cord-010119-t1x9gknd 8919 3 regression regression NN cord-010119-t1x9gknd 8919 4 of of IN cord-010119-t1x9gknd 8919 5 these these DT cord-010119-t1x9gknd 8919 6 factors factor NNS cord-010119-t1x9gknd 8919 7 showed show VBD cord-010119-t1x9gknd 8919 8 that that IN cord-010119-t1x9gknd 8919 9 female female JJ cord-010119-t1x9gknd 8919 10 patients patient NNS cord-010119-t1x9gknd 8919 11 ( ( -LRB- cord-010119-t1x9gknd 8919 12 OR or CC cord-010119-t1x9gknd 8919 13 1,726 1,726 CD cord-010119-t1x9gknd 8919 14 -95 -95 NN cord-010119-t1x9gknd 8919 15 % % NN cord-010119-t1x9gknd 8919 16 CI ci NN cord-010119-t1x9gknd 8919 17 : : : cord-010119-t1x9gknd 8919 18 1,147 1,147 CD cord-010119-t1x9gknd 8919 19 - - HYPH cord-010119-t1x9gknd 8919 20 2,597 2,597 CD cord-010119-t1x9gknd 8919 21 , , , cord-010119-t1x9gknd 8919 22 p:0,009 p:0,009 NN cord-010119-t1x9gknd 8919 23 ) ) -RRB- cord-010119-t1x9gknd 8919 24 , , , cord-010119-t1x9gknd 8919 25 absence absence NN cord-010119-t1x9gknd 8919 26 of of IN cord-010119-t1x9gknd 8919 27 HCC HCC NNP cord-010119-t1x9gknd 8919 28 ( ( -LRB- cord-010119-t1x9gknd 8919 29 OR or CC cord-010119-t1x9gknd 8919 30 0,295 0,295 CD cord-010119-t1x9gknd 8919 31 -95 -95 NN cord-010119-t1x9gknd 8919 32 % % NN cord-010119-t1x9gknd 8919 33 CI:0,199 CI:0,199 NNP cord-010119-t1x9gknd 8919 34 - - HYPH cord-010119-t1x9gknd 8919 35 0,437 0,437 CD cord-010119-t1x9gknd 8919 36 , , , cord-010119-t1x9gknd 8919 37 p:0,0 p:0,0 NNP cord-010119-t1x9gknd 8919 38 ) ) -RRB- cord-010119-t1x9gknd 8919 39 , , , cord-010119-t1x9gknd 8919 40 cirrhosis cirrhosis NN cord-010119-t1x9gknd 8919 41 of of IN cord-010119-t1x9gknd 8919 42 any any DT cord-010119-t1x9gknd 8919 43 cause cause NN cord-010119-t1x9gknd 8919 44 ( ( -LRB- cord-010119-t1x9gknd 8919 45 OR or CC cord-010119-t1x9gknd 8919 46 4,161 4,161 CD cord-010119-t1x9gknd 8919 47 -95 -95 NN cord-010119-t1x9gknd 8919 48 % % NN cord-010119-t1x9gknd 8919 49 CI CI NNP cord-010119-t1x9gknd 8919 50 1,816 1,816 CD cord-010119-t1x9gknd 8919 51 - - HYPH cord-010119-t1x9gknd 8919 52 9,534 9,534 CD cord-010119-t1x9gknd 8919 53 -p:0,001 -p:0,001 NNS cord-010119-t1x9gknd 8919 54 ) ) -RRB- cord-010119-t1x9gknd 8919 55 , , , cord-010119-t1x9gknd 8919 56 miscellaneous miscellaneous JJ cord-010119-t1x9gknd 8919 57 diagnosis diagnosis NN cord-010119-t1x9gknd 8919 58 ( ( -LRB- cord-010119-t1x9gknd 8919 59 auto auto NN cord-010119-t1x9gknd 8919 60 - - HYPH cord-010119-t1x9gknd 8919 61 immune immune JJ cord-010119-t1x9gknd 8919 62 , , , cord-010119-t1x9gknd 8919 63 metabolic metabolic JJ cord-010119-t1x9gknd 8919 64 diseases disease NNS cord-010119-t1x9gknd 8919 65 , , , cord-010119-t1x9gknd 8919 66 familial familial JJ cord-010119-t1x9gknd 8919 67 amyloid amyloid NN cord-010119-t1x9gknd 8919 68 polyneuropathy polyneuropathy NNS cord-010119-t1x9gknd 8919 69 , , , cord-010119-t1x9gknd 8919 70 vascular vascular JJ cord-010119-t1x9gknd 8919 71 complications complication NNS cord-010119-t1x9gknd 8919 72 ) ) -RRB- cord-010119-t1x9gknd 8919 73 ( ( -LRB- cord-010119-t1x9gknd 8919 74 OR or CC cord-010119-t1x9gknd 8919 75 5,236 5,236 CD cord-010119-t1x9gknd 8919 76 95%IC 95%ic CD cord-010119-t1x9gknd 8919 77 2,212 2,212 CD cord-010119-t1x9gknd 8919 78 - - SYM cord-010119-t1x9gknd 8919 79 12,394 12,394 CD cord-010119-t1x9gknd 8919 80 ) ) -RRB- cord-010119-t1x9gknd 8919 81 and and CC cord-010119-t1x9gknd 8919 82 retransplantation retransplantation NN cord-010119-t1x9gknd 8919 83 due due IN cord-010119-t1x9gknd 8919 84 to to IN cord-010119-t1x9gknd 8919 85 primary primary JJ cord-010119-t1x9gknd 8919 86 non non JJ cord-010119-t1x9gknd 8919 87 function function NN cord-010119-t1x9gknd 8919 88 of of IN cord-010119-t1x9gknd 8919 89 the the DT cord-010119-t1x9gknd 8919 90 graft graft NN cord-010119-t1x9gknd 8919 91 ( ( -LRB- cord-010119-t1x9gknd 8919 92 OR or CC cord-010119-t1x9gknd 8919 93 5,791 5,791 CD cord-010119-t1x9gknd 8919 94 95%CI 95%ci CD cord-010119-t1x9gknd 8919 95 1,33 1,33 CD cord-010119-t1x9gknd 8919 96 - - HYPH cord-010119-t1x9gknd 8919 97 4,25,206 4,25,206 CD cord-010119-t1x9gknd 8919 98 , , , cord-010119-t1x9gknd 8919 99 p p NN cord-010119-t1x9gknd 8919 100 : : : cord-010119-t1x9gknd 8919 101 0,019 0,019 CD cord-010119-t1x9gknd 8919 102 ) ) -RRB- cord-010119-t1x9gknd 8919 103 were be VBD cord-010119-t1x9gknd 8919 104 independently independently RB cord-010119-t1x9gknd 8919 105 associated associate VBN cord-010119-t1x9gknd 8919 106 with with IN cord-010119-t1x9gknd 8919 107 RBC RBC NNP cord-010119-t1x9gknd 8919 108 transfusion transfusion NN cord-010119-t1x9gknd 8919 109 requirements requirement NNS cord-010119-t1x9gknd 8919 110 . . . cord-010119-t1x9gknd 8920 1 Conclusion conclusion NN cord-010119-t1x9gknd 8920 2 : : : cord-010119-t1x9gknd 8920 3 In in IN cord-010119-t1x9gknd 8920 4 this this DT cord-010119-t1x9gknd 8920 5 study study NN cord-010119-t1x9gknd 8920 6 , , , cord-010119-t1x9gknd 8920 7 female female JJ cord-010119-t1x9gknd 8920 8 patients patient NNS cord-010119-t1x9gknd 8920 9 , , , cord-010119-t1x9gknd 8920 10 absence absence NN cord-010119-t1x9gknd 8920 11 of of IN cord-010119-t1x9gknd 8920 12 HCC HCC NNP cord-010119-t1x9gknd 8920 13 , , , cord-010119-t1x9gknd 8920 14 specific specific JJ cord-010119-t1x9gknd 8920 15 primary primary JJ cord-010119-t1x9gknd 8920 16 diagnosis diagnosis NN cord-010119-t1x9gknd 8920 17 and and CC cord-010119-t1x9gknd 8920 18 retransplantation retransplantation NN cord-010119-t1x9gknd 8920 19 due due IN cord-010119-t1x9gknd 8920 20 to to IN cord-010119-t1x9gknd 8920 21 primary primary JJ cord-010119-t1x9gknd 8920 22 non non JJ cord-010119-t1x9gknd 8920 23 function function NN cord-010119-t1x9gknd 8920 24 of of IN cord-010119-t1x9gknd 8920 25 the the DT cord-010119-t1x9gknd 8920 26 graft graft NN cord-010119-t1x9gknd 8920 27 were be VBD cord-010119-t1x9gknd 8920 28 significantly significantly RB cord-010119-t1x9gknd 8920 29 associated associate VBN cord-010119-t1x9gknd 8920 30 with with IN cord-010119-t1x9gknd 8920 31 RBC RBC NNP cord-010119-t1x9gknd 8920 32 consumption consumption NN cord-010119-t1x9gknd 8920 33 in in IN cord-010119-t1x9gknd 8920 34 intraoperative intraoperative JJ cord-010119-t1x9gknd 8920 35 period period NN cord-010119-t1x9gknd 8920 36 . . . cord-010119-t1x9gknd 8921 1 Determination determination NN cord-010119-t1x9gknd 8921 2 of of IN cord-010119-t1x9gknd 8921 3 RBC RBC NNP cord-010119-t1x9gknd 8921 4 transfusion transfusion NN cord-010119-t1x9gknd 8921 5 predictors predictor NNS cord-010119-t1x9gknd 8921 6 before before IN cord-010119-t1x9gknd 8921 7 surgery surgery NN cord-010119-t1x9gknd 8921 8 might may MD cord-010119-t1x9gknd 8921 9 provide provide VB cord-010119-t1x9gknd 8921 10 important important JJ cord-010119-t1x9gknd 8921 11 information information NN cord-010119-t1x9gknd 8921 12 regarding regard VBG cord-010119-t1x9gknd 8921 13 management management NN cord-010119-t1x9gknd 8921 14 of of IN cord-010119-t1x9gknd 8921 15 blood blood NN cord-010119-t1x9gknd 8921 16 components component NNS cord-010119-t1x9gknd 8921 17 and and CC cord-010119-t1x9gknd 8921 18 help help VB cord-010119-t1x9gknd 8921 19 optimise optimise VB cord-010119-t1x9gknd 8921 20 utilisation utilisation NN cord-010119-t1x9gknd 8921 21 of of IN cord-010119-t1x9gknd 8921 22 resources resource NNS cord-010119-t1x9gknd 8921 23 for for IN cord-010119-t1x9gknd 8921 24 blood blood NN cord-010119-t1x9gknd 8921 25 conservation conservation NN cord-010119-t1x9gknd 8921 26 strategies strategy NNS cord-010119-t1x9gknd 8921 27 . . . cord-010119-t1x9gknd 8922 1 Prevalence prevalence NN cord-010119-t1x9gknd 8922 2 of of IN cord-010119-t1x9gknd 8922 3 High High NNP cord-010119-t1x9gknd 8922 4 - - HYPH cord-010119-t1x9gknd 8922 5 Titer Titer NNP cord-010119-t1x9gknd 8922 6 Anti Anti NNP cord-010119-t1x9gknd 8922 7 - - NNP cord-010119-t1x9gknd 8922 8 A1 A1 NNP cord-010119-t1x9gknd 8922 9 / / SYM cord-010119-t1x9gknd 8922 10 B B NNP cord-010119-t1x9gknd 8922 11 in in IN cord-010119-t1x9gknd 8922 12 Group Group NNP cord-010119-t1x9gknd 8922 13 O O NNP cord-010119-t1x9gknd 8922 14 Platelet Platelet NNP cord-010119-t1x9gknd 8922 15 Products Products NNPS cord-010119-t1x9gknd 8922 16 . . . cord-010119-t1x9gknd 8923 1 Charles Charles NNP cord-010119-t1x9gknd 8923 2 K. K. NNP cord-010119-t1x9gknd 8923 3 Childers Childers NNP cord-010119-t1x9gknd 8923 4 * * NFP cord-010119-t1x9gknd 8923 5 1 1 CD cord-010119-t1x9gknd 8923 6 , , , cord-010119-t1x9gknd 8923 7 Mark Mark NNP cord-010119-t1x9gknd 8923 8 Destree Destree NNP cord-010119-t1x9gknd 8923 9 2 2 CD cord-010119-t1x9gknd 8923 10 , , , cord-010119-t1x9gknd 8923 11 Ashley Ashley NNP cord-010119-t1x9gknd 8923 12 Rose Rose NNP cord-010119-t1x9gknd 8923 13 2 2 CD cord-010119-t1x9gknd 8923 14 and and CC cord-010119-t1x9gknd 8923 15 Theresa Theresa NNP cord-010119-t1x9gknd 8923 16 Nester Nester NNP cord-010119-t1x9gknd 8924 1 3,4 3,4 CD cord-010119-t1x9gknd 8924 2 . . . cord-010119-t1x9gknd 8925 1 1 1 LS cord-010119-t1x9gknd 8926 1 Madigan Madigan NNP cord-010119-t1x9gknd 8926 2 Army Army NNP cord-010119-t1x9gknd 8926 3 Medical Medical NNP cord-010119-t1x9gknd 8926 4 Center Center NNP cord-010119-t1x9gknd 8926 5 , , , cord-010119-t1x9gknd 8926 6 2 2 CD cord-010119-t1x9gknd 8926 7 Bloodworks Bloodworks NNP cord-010119-t1x9gknd 8926 8 Northwest Northwest NNP cord-010119-t1x9gknd 8926 9 , , , cord-010119-t1x9gknd 8926 10 3 3 CD cord-010119-t1x9gknd 8926 11 Bloodworks Bloodworks NNP cord-010119-t1x9gknd 8926 12 NW NW NNP cord-010119-t1x9gknd 8926 13 , , , cord-010119-t1x9gknd 8926 14 4 4 CD cord-010119-t1x9gknd 8926 15 Dept Dept NNP cord-010119-t1x9gknd 8926 16 of of IN cord-010119-t1x9gknd 8926 17 Laboratory Laboratory NNP cord-010119-t1x9gknd 8926 18 Medicine Medicine NNP cord-010119-t1x9gknd 8926 19 , , , cord-010119-t1x9gknd 8926 20 University University NNP cord-010119-t1x9gknd 8926 21 of of IN cord-010119-t1x9gknd 8926 22 Washington Washington NNP cord-010119-t1x9gknd 8926 23 Background Background NNP cord-010119-t1x9gknd 8926 24 / / SYM cord-010119-t1x9gknd 8926 25 Case Case NNP cord-010119-t1x9gknd 8926 26 Studies Studies NNPS cord-010119-t1x9gknd 8926 27 : : : cord-010119-t1x9gknd 8927 1 With with IN cord-010119-t1x9gknd 8927 2 platelet platelet NN cord-010119-t1x9gknd 8927 3 substitution substitution NN cord-010119-t1x9gknd 8927 4 policies policy NNS cord-010119-t1x9gknd 8927 5 , , , cord-010119-t1x9gknd 8927 6 minor minor JJ cord-010119-t1x9gknd 8927 7 ABOincompatible aboincompatible JJ cord-010119-t1x9gknd 8927 8 platelets platelet NNS cord-010119-t1x9gknd 8927 9 ( ( -LRB- cord-010119-t1x9gknd 8927 10 where where WRB cord-010119-t1x9gknd 8927 11 donor donor NN cord-010119-t1x9gknd 8927 12 's 's POS cord-010119-t1x9gknd 8927 13 plasma plasma NN cord-010119-t1x9gknd 8927 14 may may MD cord-010119-t1x9gknd 8927 15 contain contain VB cord-010119-t1x9gknd 8927 16 antibodies antibody NNS cord-010119-t1x9gknd 8927 17 to to IN cord-010119-t1x9gknd 8927 18 recipient recipient NN cord-010119-t1x9gknd 8927 19 's 's POS cord-010119-t1x9gknd 8927 20 red red JJ cord-010119-t1x9gknd 8927 21 blood blood NN cord-010119-t1x9gknd 8927 22 cells cell NNS cord-010119-t1x9gknd 8927 23 ) ) -RRB- cord-010119-t1x9gknd 8927 24 are be VBP cord-010119-t1x9gknd 8927 25 often often RB cord-010119-t1x9gknd 8927 26 issued issue VBN cord-010119-t1x9gknd 8927 27 in in IN cord-010119-t1x9gknd 8927 28 an an DT cord-010119-t1x9gknd 8927 29 effort effort NN cord-010119-t1x9gknd 8927 30 to to TO cord-010119-t1x9gknd 8927 31 best best RB cord-010119-t1x9gknd 8927 32 utilize utilize VB cord-010119-t1x9gknd 8927 33 the the DT cord-010119-t1x9gknd 8927 34 community community NN cord-010119-t1x9gknd 8927 35 supply supply NN cord-010119-t1x9gknd 8927 36 . . . cord-010119-t1x9gknd 8928 1 However however RB cord-010119-t1x9gknd 8928 2 , , , cord-010119-t1x9gknd 8928 3 rare rare JJ cord-010119-t1x9gknd 8928 4 reports report NNS cord-010119-t1x9gknd 8928 5 of of IN cord-010119-t1x9gknd 8928 6 acute acute JJ cord-010119-t1x9gknd 8928 7 intravascular intravascular JJ cord-010119-t1x9gknd 8928 8 hemolysis hemolysis NN cord-010119-t1x9gknd 8928 9 have have VBP cord-010119-t1x9gknd 8928 10 been be VBN cord-010119-t1x9gknd 8928 11 reported report VBN cord-010119-t1x9gknd 8928 12 from from IN cord-010119-t1x9gknd 8928 13 such such JJ cord-010119-t1x9gknd 8928 14 transfusions transfusion NNS cord-010119-t1x9gknd 8928 15 , , , cord-010119-t1x9gknd 8928 16 and and CC cord-010119-t1x9gknd 8928 17 can can MD cord-010119-t1x9gknd 8928 18 be be VB cord-010119-t1x9gknd 8928 19 attributed attribute VBN cord-010119-t1x9gknd 8928 20 to to IN cord-010119-t1x9gknd 8928 21 high high JJ cord-010119-t1x9gknd 8928 22 Anti Anti NNP cord-010119-t1x9gknd 8928 23 - - NNP cord-010119-t1x9gknd 8928 24 A1 A1 NNP cord-010119-t1x9gknd 8928 25 or or CC cord-010119-t1x9gknd 8928 26 anti anti JJ cord-010119-t1x9gknd 8928 27 - - JJ cord-010119-t1x9gknd 8928 28 B b JJ cord-010119-t1x9gknd 8928 29 titers titer NNS cord-010119-t1x9gknd 8928 30 , , , cord-010119-t1x9gknd 8928 31 typically typically RB cord-010119-t1x9gknd 8928 32 in in IN cord-010119-t1x9gknd 8928 33 a a DT cord-010119-t1x9gknd 8928 34 group group NN cord-010119-t1x9gknd 8928 35 O o NN cord-010119-t1x9gknd 8928 36 donor donor NN cord-010119-t1x9gknd 8928 37 . . . cord-010119-t1x9gknd 8929 1 One one CD cord-010119-t1x9gknd 8929 2 method method NN cord-010119-t1x9gknd 8929 3 to to TO cord-010119-t1x9gknd 8929 4 reduce reduce VB cord-010119-t1x9gknd 8929 5 the the DT cord-010119-t1x9gknd 8929 6 risk risk NN cord-010119-t1x9gknd 8929 7 of of IN cord-010119-t1x9gknd 8929 8 hemolysis hemolysis NN cord-010119-t1x9gknd 8929 9 is be VBZ cord-010119-t1x9gknd 8929 10 to to TO cord-010119-t1x9gknd 8929 11 identify identify VB cord-010119-t1x9gknd 8929 12 high high JJ cord-010119-t1x9gknd 8929 13 titer titer NN cord-010119-t1x9gknd 8929 14 platelet platelet NN cord-010119-t1x9gknd 8929 15 units unit NNS cord-010119-t1x9gknd 8929 16 prior prior RB cord-010119-t1x9gknd 8929 17 to to IN cord-010119-t1x9gknd 8929 18 transfusion transfusion NN cord-010119-t1x9gknd 8929 19 with with IN cord-010119-t1x9gknd 8929 20 a a DT cord-010119-t1x9gknd 8929 21 subsequent subsequent JJ cord-010119-t1x9gknd 8929 22 intervention intervention NN cord-010119-t1x9gknd 8929 23 . . . cord-010119-t1x9gknd 8930 1 The the DT cord-010119-t1x9gknd 8930 2 percentage percentage NN cord-010119-t1x9gknd 8930 3 of of IN cord-010119-t1x9gknd 8930 4 high high JJ cord-010119-t1x9gknd 8930 5 titer titer NN cord-010119-t1x9gknd 8930 6 Anti Anti NNP cord-010119-t1x9gknd 8930 7 - - NNP cord-010119-t1x9gknd 8930 8 A1 A1 NNP cord-010119-t1x9gknd 8930 9 / / SYM cord-010119-t1x9gknd 8930 10 B B NNP cord-010119-t1x9gknd 8930 11 in in IN cord-010119-t1x9gknd 8930 12 group group NN cord-010119-t1x9gknd 8930 13 O o NN cord-010119-t1x9gknd 8930 14 platelet platelet NN cord-010119-t1x9gknd 8930 15 products product NNS cord-010119-t1x9gknd 8930 16 is be VBZ cord-010119-t1x9gknd 8930 17 presented present VBN cord-010119-t1x9gknd 8930 18 from from IN cord-010119-t1x9gknd 8930 19 a a DT cord-010119-t1x9gknd 8930 20 large large JJ cord-010119-t1x9gknd 8930 21 regional regional JJ cord-010119-t1x9gknd 8930 22 blood blood NN cord-010119-t1x9gknd 8930 23 center center NN cord-010119-t1x9gknd 8930 24 collected collect VBN cord-010119-t1x9gknd 8930 25 over over IN cord-010119-t1x9gknd 8930 26 10 10 CD cord-010119-t1x9gknd 8930 27 - - SYM cord-010119-t1x9gknd 8930 28 12 12 CD cord-010119-t1x9gknd 8930 29 months month NNS cord-010119-t1x9gknd 8930 30 . . . cord-010119-t1x9gknd 8931 1 Data datum NNS cord-010119-t1x9gknd 8931 2 from from IN cord-010119-t1x9gknd 8931 3 both both DT cord-010119-t1x9gknd 8931 4 pre pre JJ cord-010119-t1x9gknd 8931 5 - - JJ cord-010119-t1x9gknd 8931 6 storage storage JJ cord-010119-t1x9gknd 8931 7 pooled pool VBN cord-010119-t1x9gknd 8931 8 platelet platelet NN cord-010119-t1x9gknd 8931 9 units unit NNS cord-010119-t1x9gknd 8931 10 ( ( -LRB- cord-010119-t1x9gknd 8931 11 PSPP PSPP NNP cord-010119-t1x9gknd 8931 12 ) ) -RRB- cord-010119-t1x9gknd 8931 13 and and CC cord-010119-t1x9gknd 8931 14 apheresis apheresis NN cord-010119-t1x9gknd 8931 15 derived derive VBN cord-010119-t1x9gknd 8931 16 platelet platelet NN cord-010119-t1x9gknd 8931 17 units unit NNS cord-010119-t1x9gknd 8931 18 ( ( -LRB- cord-010119-t1x9gknd 8931 19 APLT APLT NNP cord-010119-t1x9gknd 8931 20 ) ) -RRB- cord-010119-t1x9gknd 8931 21 is be VBZ cord-010119-t1x9gknd 8931 22 shown show VBN cord-010119-t1x9gknd 8931 23 . . . cord-010119-t1x9gknd 8932 1 Study Study NNP cord-010119-t1x9gknd 8932 2 Design Design NNP cord-010119-t1x9gknd 8932 3 / / SYM cord-010119-t1x9gknd 8932 4 Method method NN cord-010119-t1x9gknd 8932 5 : : : cord-010119-t1x9gknd 8932 6 Platelet platelet NN cord-010119-t1x9gknd 8932 7 component component NN cord-010119-t1x9gknd 8932 8 samples sample NNS cord-010119-t1x9gknd 8932 9 were be VBD cord-010119-t1x9gknd 8932 10 collected collect VBN cord-010119-t1x9gknd 8932 11 in in IN cord-010119-t1x9gknd 8932 12 2 2 CD cord-010119-t1x9gknd 8932 13 mL ml NN cord-010119-t1x9gknd 8932 14 EDTA edta NN cord-010119-t1x9gknd 8932 15 sample sample NN cord-010119-t1x9gknd 8932 16 tubes tube NNS cord-010119-t1x9gknd 8932 17 . . . cord-010119-t1x9gknd 8933 1 A a DT cord-010119-t1x9gknd 8933 2 single single JJ cord-010119-t1x9gknd 8933 3 1:150 1:150 CD cord-010119-t1x9gknd 8933 4 dilution dilution NN cord-010119-t1x9gknd 8933 5 of of IN cord-010119-t1x9gknd 8933 6 plasma plasma NN cord-010119-t1x9gknd 8933 7 was be VBD cord-010119-t1x9gknd 8933 8 prepared prepare VBN cord-010119-t1x9gknd 8933 9 using use VBG cord-010119-t1x9gknd 8933 10 a a DT cord-010119-t1x9gknd 8933 11 Hamilton Hamilton NNP cord-010119-t1x9gknd 8933 12 MicroLAB MicroLAB NNP cord-010119-t1x9gknd 8933 13 600 600 CD cord-010119-t1x9gknd 8933 14 series series NN cord-010119-t1x9gknd 8933 15 dilutor dilutor NN cord-010119-t1x9gknd 8933 16 using use VBG cord-010119-t1x9gknd 8933 17 2235.0 2235.0 CD cord-010119-t1x9gknd 8933 18 mL ml NN cord-010119-t1x9gknd 8933 19 saline saline NN cord-010119-t1x9gknd 8933 20 diluent diluent NN cord-010119-t1x9gknd 8933 21 and and CC cord-010119-t1x9gknd 8933 22 15.0 15.0 CD cord-010119-t1x9gknd 8933 23 mL ml NN cord-010119-t1x9gknd 8933 24 platelet platelet NN cord-010119-t1x9gknd 8933 25 component component NN cord-010119-t1x9gknd 8933 26 sample sample NN cord-010119-t1x9gknd 8933 27 . . . cord-010119-t1x9gknd 8934 1 Using use VBG cord-010119-t1x9gknd 8934 2 a a DT cord-010119-t1x9gknd 8934 3 standard standard JJ cord-010119-t1x9gknd 8934 4 transfer transfer NN cord-010119-t1x9gknd 8934 5 pipette pipette NN cord-010119-t1x9gknd 8934 6 , , , cord-010119-t1x9gknd 8934 7 two two CD cord-010119-t1x9gknd 8934 8 drops drop NNS cord-010119-t1x9gknd 8934 9 of of IN cord-010119-t1x9gknd 8934 10 diluted dilute VBN cord-010119-t1x9gknd 8934 11 sample sample NN cord-010119-t1x9gknd 8934 12 were be VBD cord-010119-t1x9gknd 8934 13 transferred transfer VBN cord-010119-t1x9gknd 8934 14 to to IN cord-010119-t1x9gknd 8934 15 each each DT cord-010119-t1x9gknd 8934 16 reaction reaction NN cord-010119-t1x9gknd 8934 17 tube tube NN cord-010119-t1x9gknd 8934 18 along along RP cord-010119-t1x9gknd 8934 19 with with IN cord-010119-t1x9gknd 8934 20 one one CD cord-010119-t1x9gknd 8934 21 drop drop NN cord-010119-t1x9gknd 8934 22 of of IN cord-010119-t1x9gknd 8934 23 A1 A1 NNP cord-010119-t1x9gknd 8934 24 or or CC cord-010119-t1x9gknd 8934 25 B B NNP cord-010119-t1x9gknd 8934 26 red red JJ cord-010119-t1x9gknd 8934 27 blood blood NN cord-010119-t1x9gknd 8934 28 cell cell NN cord-010119-t1x9gknd 8934 29 reagent reagent NN cord-010119-t1x9gknd 8934 30 . . . cord-010119-t1x9gknd 8935 1 Reaction reaction NN cord-010119-t1x9gknd 8935 2 tubes tube NNS cord-010119-t1x9gknd 8935 3 were be VBD cord-010119-t1x9gknd 8935 4 centrifuged centrifuge VBN cord-010119-t1x9gknd 8935 5 immediately immediately RB cord-010119-t1x9gknd 8935 6 in in IN cord-010119-t1x9gknd 8935 7 a a DT cord-010119-t1x9gknd 8935 8 serological serological JJ cord-010119-t1x9gknd 8935 9 centrifuge centrifuge NN cord-010119-t1x9gknd 8935 10 at at IN cord-010119-t1x9gknd 8935 11 3175 3175 CD cord-010119-t1x9gknd 8935 12 rpm rpm NN cord-010119-t1x9gknd 8935 13 for for IN cord-010119-t1x9gknd 8935 14 20 20 CD cord-010119-t1x9gknd 8935 15 seconds second NNS cord-010119-t1x9gknd 8935 16 . . . cord-010119-t1x9gknd 8936 1 Reactions reaction NNS cord-010119-t1x9gknd 8936 2 were be VBD cord-010119-t1x9gknd 8936 3 read read VBN cord-010119-t1x9gknd 8936 4 using use VBG cord-010119-t1x9gknd 8936 5 a a DT cord-010119-t1x9gknd 8936 6 lighted light VBN cord-010119-t1x9gknd 8936 7 agglutination agglutination NN cord-010119-t1x9gknd 8936 8 reader reader NN cord-010119-t1x9gknd 8936 9 . . . cord-010119-t1x9gknd 8937 1 The the DT cord-010119-t1x9gknd 8937 2 presence presence NN cord-010119-t1x9gknd 8937 3 of of IN cord-010119-t1x9gknd 8937 4 macroscopic macroscopic JJ cord-010119-t1x9gknd 8937 5 agglutination agglutination NN cord-010119-t1x9gknd 8937 6 ( ( -LRB- cord-010119-t1x9gknd 8937 7 weak weak JJ cord-010119-t1x9gknd 8937 8 or or CC cord-010119-t1x9gknd 8937 9 greater great JJR cord-010119-t1x9gknd 8937 10 ) ) -RRB- cord-010119-t1x9gknd 8937 11 with with IN cord-010119-t1x9gknd 8937 12 either either CC cord-010119-t1x9gknd 8937 13 the the DT cord-010119-t1x9gknd 8937 14 A1 A1 NNP cord-010119-t1x9gknd 8937 15 cells cell NNS cord-010119-t1x9gknd 8937 16 or or CC cord-010119-t1x9gknd 8937 17 B b NN cord-010119-t1x9gknd 8937 18 cells cell NNS cord-010119-t1x9gknd 8937 19 was be VBD cord-010119-t1x9gknd 8937 20 recorded record VBN cord-010119-t1x9gknd 8937 21 as as IN cord-010119-t1x9gknd 8937 22 a a DT cord-010119-t1x9gknd 8937 23 positive positive JJ cord-010119-t1x9gknd 8937 24 reaction reaction NN cord-010119-t1x9gknd 8937 25 , , , cord-010119-t1x9gknd 8937 26 indicative indicative JJ cord-010119-t1x9gknd 8937 27 of of IN cord-010119-t1x9gknd 8937 28 a a DT cord-010119-t1x9gknd 8937 29 high high JJ cord-010119-t1x9gknd 8937 30 titer titer NN cord-010119-t1x9gknd 8937 31 Anti Anti NNP cord-010119-t1x9gknd 8937 32 - - NNP cord-010119-t1x9gknd 8937 33 A1 A1 NNP cord-010119-t1x9gknd 8937 34 or or CC cord-010119-t1x9gknd 8937 35 Anti Anti NNP cord-010119-t1x9gknd 8937 36 - - NNP cord-010119-t1x9gknd 8937 37 B. B. NNP cord-010119-t1x9gknd 8937 38 Retesting retesting NN cord-010119-t1x9gknd 8937 39 of of IN cord-010119-t1x9gknd 8937 40 samples sample NNS cord-010119-t1x9gknd 8937 41 was be VBD cord-010119-t1x9gknd 8937 42 performed perform VBN cord-010119-t1x9gknd 8937 43 to to TO cord-010119-t1x9gknd 8937 44 confirm confirm VB cord-010119-t1x9gknd 8937 45 high high JJ cord-010119-t1x9gknd 8937 46 titers titer NNS cord-010119-t1x9gknd 8937 47 . . . cord-010119-t1x9gknd 8938 1 Results/ Results/ . cord-010119-t1x9gknd 8939 1 Finding finding NN cord-010119-t1x9gknd 8939 2 : : : cord-010119-t1x9gknd 8940 1 The the DT cord-010119-t1x9gknd 8940 2 above above JJ cord-010119-t1x9gknd 8940 3 results result NNS cord-010119-t1x9gknd 8940 4 indicate indicate VBP cord-010119-t1x9gknd 8940 5 that that IN cord-010119-t1x9gknd 8940 6 , , , cord-010119-t1x9gknd 8940 7 when when WRB cord-010119-t1x9gknd 8940 8 a a DT cord-010119-t1x9gknd 8940 9 titer titer NN cord-010119-t1x9gknd 8940 10 cut cut VBN cord-010119-t1x9gknd 8940 11 - - HYPH cord-010119-t1x9gknd 8940 12 off off NN cord-010119-t1x9gknd 8940 13 of of IN cord-010119-t1x9gknd 8940 14 150 150 CD cord-010119-t1x9gknd 8940 15 is be VBZ cord-010119-t1x9gknd 8940 16 used use VBN cord-010119-t1x9gknd 8940 17 , , , cord-010119-t1x9gknd 8940 18 approximately approximately RB cord-010119-t1x9gknd 8940 19 3 3 CD cord-010119-t1x9gknd 8940 20 % % NN cord-010119-t1x9gknd 8940 21 of of IN cord-010119-t1x9gknd 8940 22 group group NN cord-010119-t1x9gknd 8940 23 O o NN cord-010119-t1x9gknd 8940 24 apheresis apheresis NN cord-010119-t1x9gknd 8940 25 platelets platelet NNS cord-010119-t1x9gknd 8940 26 will will MD cord-010119-t1x9gknd 8940 27 have have VB cord-010119-t1x9gknd 8940 28 a a DT cord-010119-t1x9gknd 8940 29 high high JJ cord-010119-t1x9gknd 8940 30 titer titer NN cord-010119-t1x9gknd 8940 31 , , , cord-010119-t1x9gknd 8940 32 most most RBS cord-010119-t1x9gknd 8940 33 commonly commonly RB cord-010119-t1x9gknd 8940 34 with with IN cord-010119-t1x9gknd 8940 35 anti anti JJ cord-010119-t1x9gknd 8940 36 - - NNP cord-010119-t1x9gknd 8940 37 A1 A1 NNP cord-010119-t1x9gknd 8940 38 . . . cord-010119-t1x9gknd 8941 1 Less Less JJR cord-010119-t1x9gknd 8941 2 than than IN cord-010119-t1x9gknd 8941 3 half half NN cord-010119-t1x9gknd 8941 4 of of IN cord-010119-t1x9gknd 8941 5 a a DT cord-010119-t1x9gknd 8941 6 percent percent NN cord-010119-t1x9gknd 8941 7 of of IN cord-010119-t1x9gknd 8941 8 PSPP PSPP NNP cord-010119-t1x9gknd 8941 9 units unit NNS cord-010119-t1x9gknd 8941 10 will will MD cord-010119-t1x9gknd 8941 11 have have VB cord-010119-t1x9gknd 8941 12 a a DT cord-010119-t1x9gknd 8941 13 high high JJ cord-010119-t1x9gknd 8941 14 titer titer NN cord-010119-t1x9gknd 8941 15 . . . cord-010119-t1x9gknd 8942 1 Testing testing NN cord-010119-t1x9gknd 8942 2 units unit NNS cord-010119-t1x9gknd 8942 3 for for IN cord-010119-t1x9gknd 8942 4 the the DT cord-010119-t1x9gknd 8942 5 titer titer NN cord-010119-t1x9gknd 8942 6 can can MD cord-010119-t1x9gknd 8942 7 help help VB cord-010119-t1x9gknd 8942 8 to to TO cord-010119-t1x9gknd 8942 9 change change VB cord-010119-t1x9gknd 8942 10 ABO ABO NNP cord-010119-t1x9gknd 8942 11 out out RB cord-010119-t1x9gknd 8942 12 - - HYPH cord-010119-t1x9gknd 8942 13 of of IN cord-010119-t1x9gknd 8942 14 - - HYPH cord-010119-t1x9gknd 8942 15 group group NN cord-010119-t1x9gknd 8942 16 platelet platelet NN cord-010119-t1x9gknd 8942 17 substitution substitution NN cord-010119-t1x9gknd 8942 18 policies policy NNS cord-010119-t1x9gknd 8942 19 . . . cord-010119-t1x9gknd 8943 1 In in IN cord-010119-t1x9gknd 8943 2 our -PRON- PRP$ cord-010119-t1x9gknd 8943 3 example example NN cord-010119-t1x9gknd 8943 4 , , , cord-010119-t1x9gknd 8943 5 the the DT cord-010119-t1x9gknd 8943 6 Bloodworks Bloodworks NNP cord-010119-t1x9gknd 8943 7 transfusion transfusion NN cord-010119-t1x9gknd 8943 8 service service NN cord-010119-t1x9gknd 8943 9 was be VBD cord-010119-t1x9gknd 8943 10 able able JJ cord-010119-t1x9gknd 8943 11 to to TO cord-010119-t1x9gknd 8943 12 change change VB cord-010119-t1x9gknd 8943 13 from from IN cord-010119-t1x9gknd 8943 14 a a DT cord-010119-t1x9gknd 8943 15 policy policy NN cord-010119-t1x9gknd 8943 16 of of IN cord-010119-t1x9gknd 8943 17 volume volume NN cord-010119-t1x9gknd 8943 18 reducing reduce VBG cord-010119-t1x9gknd 8943 19 any any DT cord-010119-t1x9gknd 8943 20 group group NN cord-010119-t1x9gknd 8943 21 O o NN cord-010119-t1x9gknd 8943 22 apheresis apheresis NN cord-010119-t1x9gknd 8943 23 platelets platelet NNS cord-010119-t1x9gknd 8943 24 being be VBG cord-010119-t1x9gknd 8943 25 issued issue VBN cord-010119-t1x9gknd 8943 26 to to IN cord-010119-t1x9gknd 8943 27 a a DT cord-010119-t1x9gknd 8943 28 group group NN cord-010119-t1x9gknd 8943 29 A a NN cord-010119-t1x9gknd 8943 30 or or CC cord-010119-t1x9gknd 8943 31 AB AB NNP cord-010119-t1x9gknd 8943 32 patient patient NN cord-010119-t1x9gknd 8943 33 , , , cord-010119-t1x9gknd 8943 34 to to IN cord-010119-t1x9gknd 8943 35 giving give VBG cord-010119-t1x9gknd 8943 36 high high JJ cord-010119-t1x9gknd 8943 37 titer titer NN cord-010119-t1x9gknd 8943 38 products product NNS cord-010119-t1x9gknd 8943 39 to to IN cord-010119-t1x9gknd 8943 40 only only RB cord-010119-t1x9gknd 8943 41 group group NN cord-010119-t1x9gknd 8943 42 O o NN cord-010119-t1x9gknd 8943 43 patients patient NNS cord-010119-t1x9gknd 8943 44 . . . cord-010119-t1x9gknd 8944 1 The the DT cord-010119-t1x9gknd 8944 2 subsequent subsequent JJ cord-010119-t1x9gknd 8944 3 decrease decrease NN cord-010119-t1x9gknd 8944 4 in in IN cord-010119-t1x9gknd 8944 5 episodes episode NNS cord-010119-t1x9gknd 8944 6 of of IN cord-010119-t1x9gknd 8944 7 volume volume NN cord-010119-t1x9gknd 8944 8 reduction reduction NN cord-010119-t1x9gknd 8944 9 helped help VBD cord-010119-t1x9gknd 8944 10 to to TO cord-010119-t1x9gknd 8944 11 improve improve VB cord-010119-t1x9gknd 8944 12 overall overall JJ cord-010119-t1x9gknd 8944 13 availability availability NN cord-010119-t1x9gknd 8944 14 of of IN cord-010119-t1x9gknd 8944 15 apheresis apheresis NN cord-010119-t1x9gknd 8944 16 platelets platelet NNS cord-010119-t1x9gknd 8944 17 , , , cord-010119-t1x9gknd 8944 18 by by IN cord-010119-t1x9gknd 8944 19 maintaining maintain VBG cord-010119-t1x9gknd 8944 20 their -PRON- PRP$ cord-010119-t1x9gknd 8944 21 5 5 CD cord-010119-t1x9gknd 8944 22 day day NN cord-010119-t1x9gknd 8944 23 outdate outdate RB cord-010119-t1x9gknd 8944 24 . . . cord-010119-t1x9gknd 8945 1 After after IN cord-010119-t1x9gknd 8945 2 10 10 CD cord-010119-t1x9gknd 8945 3 months month NNS cord-010119-t1x9gknd 8945 4 of of IN cord-010119-t1x9gknd 8945 5 testing test VBG cord-010119-t1x9gknd 8945 6 PSPP PSPP NNP cord-010119-t1x9gknd 8945 7 units unit NNS cord-010119-t1x9gknd 8945 8 and and CC cord-010119-t1x9gknd 8945 9 verifying verify VBG cord-010119-t1x9gknd 8945 10 that that IN cord-010119-t1x9gknd 8945 11 the the DT cord-010119-t1x9gknd 8945 12 products product NNS cord-010119-t1x9gknd 8945 13 rarely rarely RB cord-010119-t1x9gknd 8945 14 had have VBD cord-010119-t1x9gknd 8945 15 a a DT cord-010119-t1x9gknd 8945 16 high high JJ cord-010119-t1x9gknd 8945 17 titer titer NN cord-010119-t1x9gknd 8945 18 ( ( -LRB- cord-010119-t1x9gknd 8945 19 0.28 0.28 CD cord-010119-t1x9gknd 8945 20 % % NN cord-010119-t1x9gknd 8945 21 ) ) -RRB- cord-010119-t1x9gknd 8945 22 , , , cord-010119-t1x9gknd 8945 23 the the DT cord-010119-t1x9gknd 8945 24 blood blood NN cord-010119-t1x9gknd 8945 25 center center NN cord-010119-t1x9gknd 8945 26 stopped stop VBD cord-010119-t1x9gknd 8945 27 performing perform VBG cord-010119-t1x9gknd 8945 28 this this DT cord-010119-t1x9gknd 8945 29 testing testing NN cord-010119-t1x9gknd 8945 30 for for IN cord-010119-t1x9gknd 8945 31 PSPP PSPP NNP cord-010119-t1x9gknd 8945 32 units unit NNS cord-010119-t1x9gknd 8945 33 . . . cord-010119-t1x9gknd 8946 1 Rh1 rh1 LS cord-010119-t1x9gknd 8946 2 ) ) -RRB- cord-010119-t1x9gknd 8946 3 ] ] -RRB- cord-010119-t1x9gknd 8947 1 started start VBD cord-010119-t1x9gknd 8947 2 complaining complain VBG cord-010119-t1x9gknd 8947 3 of of IN cord-010119-t1x9gknd 8947 4 worsening worsen VBG cord-010119-t1x9gknd 8947 5 back back JJ cord-010119-t1x9gknd 8947 6 pain pain NN cord-010119-t1x9gknd 8947 7 two two CD cord-010119-t1x9gknd 8947 8 and and CC cord-010119-t1x9gknd 8947 9 half half NN cord-010119-t1x9gknd 8947 10 hours hour NNS cord-010119-t1x9gknd 8947 11 after after IN cord-010119-t1x9gknd 8947 12 receiving receive VBG cord-010119-t1x9gknd 8947 13 one one CD cord-010119-t1x9gknd 8947 14 unit unit NN cord-010119-t1x9gknd 8947 15 of of IN cord-010119-t1x9gknd 8947 16 RBC RBC NNP cord-010119-t1x9gknd 8947 17 for for IN cord-010119-t1x9gknd 8947 18 a a DT cord-010119-t1x9gknd 8947 19 drop drop NN cord-010119-t1x9gknd 8947 20 in in IN cord-010119-t1x9gknd 8947 21 hematocrit hematocrit NN cord-010119-t1x9gknd 8947 22 to to IN cord-010119-t1x9gknd 8947 23 19 19 CD cord-010119-t1x9gknd 8947 24 % % NN cord-010119-t1x9gknd 8947 25 ( ( -LRB- cord-010119-t1x9gknd 8947 26 from from IN cord-010119-t1x9gknd 8947 27 24 24 CD cord-010119-t1x9gknd 8947 28 % % NN cord-010119-t1x9gknd 8947 29 on on IN cord-010119-t1x9gknd 8947 30 the the DT cord-010119-t1x9gknd 8947 31 previous previous JJ cord-010119-t1x9gknd 8947 32 day day NN cord-010119-t1x9gknd 8947 33 ) ) -RRB- cord-010119-t1x9gknd 8947 34 . . . cord-010119-t1x9gknd 8948 1 His -PRON- PRP$ cord-010119-t1x9gknd 8948 2 hematocrit hematocrit NN cord-010119-t1x9gknd 8948 3 did do VBD cord-010119-t1x9gknd 8948 4 not not RB cord-010119-t1x9gknd 8948 5 increase increase VB cord-010119-t1x9gknd 8948 6 ( ( -LRB- cord-010119-t1x9gknd 8948 7 18 18 CD cord-010119-t1x9gknd 8948 8 % % NN cord-010119-t1x9gknd 8948 9 ) ) -RRB- cord-010119-t1x9gknd 8948 10 , , , cord-010119-t1x9gknd 8948 11 and and CC cord-010119-t1x9gknd 8948 12 over over IN cord-010119-t1x9gknd 8948 13 the the DT cord-010119-t1x9gknd 8948 14 ensuing ensue VBG cord-010119-t1x9gknd 8948 15 12 12 CD cord-010119-t1x9gknd 8948 16 hours hour NNS cord-010119-t1x9gknd 8948 17 , , , cord-010119-t1x9gknd 8948 18 he -PRON- PRP cord-010119-t1x9gknd 8948 19 became become VBD cord-010119-t1x9gknd 8948 20 anuric anuric JJ cord-010119-t1x9gknd 8948 21 and and CC cord-010119-t1x9gknd 8948 22 jaundiced jaundiced JJ cord-010119-t1x9gknd 8948 23 . . . cord-010119-t1x9gknd 8949 1 Clerical clerical JJ cord-010119-t1x9gknd 8949 2 checks check NNS cord-010119-t1x9gknd 8949 3 confirmed confirm VBD cord-010119-t1x9gknd 8949 4 that that IN cord-010119-t1x9gknd 8949 5 his -PRON- PRP$ cord-010119-t1x9gknd 8949 6 forward forward JJ cord-010119-t1x9gknd 8949 7 type type NN cord-010119-t1x9gknd 8949 8 was be VBD cord-010119-t1x9gknd 8949 9 A a DT cord-010119-t1x9gknd 8949 10 positive positive JJ cord-010119-t1x9gknd 8949 11 , , , cord-010119-t1x9gknd 8949 12 which which WDT cord-010119-t1x9gknd 8949 13 was be VBD cord-010119-t1x9gknd 8949 14 also also RB cord-010119-t1x9gknd 8949 15 the the DT cord-010119-t1x9gknd 8949 16 type type NN cord-010119-t1x9gknd 8949 17 of of IN cord-010119-t1x9gknd 8949 18 the the DT cord-010119-t1x9gknd 8949 19 RBC RBC NNP cord-010119-t1x9gknd 8949 20 unit unit NN cord-010119-t1x9gknd 8949 21 transfused transfuse VBN cord-010119-t1x9gknd 8949 22 , , , cord-010119-t1x9gknd 8949 23 but but CC cord-010119-t1x9gknd 8949 24 revealed reveal VBD cord-010119-t1x9gknd 8949 25 anti anti NNP cord-010119-t1x9gknd 8949 26 - - JJ cord-010119-t1x9gknd 8949 27 A a NN cord-010119-t1x9gknd 8949 28 at at IN cord-010119-t1x9gknd 8949 29 a a DT cord-010119-t1x9gknd 8949 30 titer titer NN cord-010119-t1x9gknd 8949 31 of of IN cord-010119-t1x9gknd 8949 32 8 8 CD cord-010119-t1x9gknd 8949 33 in in IN cord-010119-t1x9gknd 8949 34 his -PRON- PRP$ cord-010119-t1x9gknd 8949 35 plasma plasma NN cord-010119-t1x9gknd 8949 36 . . . cord-010119-t1x9gknd 8950 1 Furthermore furthermore RB cord-010119-t1x9gknd 8950 2 , , , cord-010119-t1x9gknd 8950 3 the the DT cord-010119-t1x9gknd 8950 4 direct direct JJ cord-010119-t1x9gknd 8950 5 antiglobulin antiglobulin NN cord-010119-t1x9gknd 8950 6 tests test NNS cord-010119-t1x9gknd 8950 7 ( ( -LRB- cord-010119-t1x9gknd 8950 8 DAT DAT NNP cord-010119-t1x9gknd 8950 9 ) ) -RRB- cord-010119-t1x9gknd 8950 10 were be VBD cord-010119-t1x9gknd 8950 11 positive positive JJ cord-010119-t1x9gknd 8950 12 for for IN cord-010119-t1x9gknd 8950 13 C3 C3 NNP cord-010119-t1x9gknd 8950 14 in in IN cord-010119-t1x9gknd 8950 15 the the DT cord-010119-t1x9gknd 8950 16 pre pre NN cord-010119-t1x9gknd 8950 17 - - JJ cord-010119-t1x9gknd 8950 18 and and CC cord-010119-t1x9gknd 8950 19 post post JJ cord-010119-t1x9gknd 8950 20 - - JJ cord-010119-t1x9gknd 8950 21 transfusion transfusion JJ cord-010119-t1x9gknd 8950 22 blood blood NN cord-010119-t1x9gknd 8950 23 samples sample NNS cord-010119-t1x9gknd 8950 24 . . . cord-010119-t1x9gknd 8951 1 Anti Anti NNP cord-010119-t1x9gknd 8951 2 - - NNP cord-010119-t1x9gknd 8951 3 A A NNP cord-010119-t1x9gknd 8951 4 was be VBD cord-010119-t1x9gknd 8951 5 not not RB cord-010119-t1x9gknd 8951 6 detected detect VBN cord-010119-t1x9gknd 8951 7 in in IN cord-010119-t1x9gknd 8951 8 his -PRON- PRP$ cord-010119-t1x9gknd 8951 9 plasma plasma NN cord-010119-t1x9gknd 8951 10 collected collect VBD cord-010119-t1x9gknd 8951 11 three three CD cord-010119-t1x9gknd 8951 12 days day NNS cord-010119-t1x9gknd 8951 13 earlier early RBR cord-010119-t1x9gknd 8951 14 , , , cord-010119-t1x9gknd 8951 15 however however RB cord-010119-t1x9gknd 8951 16 . . . cord-010119-t1x9gknd 8952 1 Although although IN cord-010119-t1x9gknd 8952 2 his -PRON- PRP$ cord-010119-t1x9gknd 8952 3 plasma plasma NN cord-010119-t1x9gknd 8952 4 color color NN cord-010119-t1x9gknd 8952 5 was be VBD cord-010119-t1x9gknd 8952 6 amber amber NN cord-010119-t1x9gknd 8952 7 , , , cord-010119-t1x9gknd 8952 8 he -PRON- PRP cord-010119-t1x9gknd 8952 9 had have VBD cord-010119-t1x9gknd 8952 10 signs sign NNS cord-010119-t1x9gknd 8952 11 of of IN cord-010119-t1x9gknd 8952 12 intravascular intravascular JJ cord-010119-t1x9gknd 8952 13 hemolysis hemolysis NN cord-010119-t1x9gknd 8952 14 : : : cord-010119-t1x9gknd 8952 15 undetectable undetectable JJ cord-010119-t1x9gknd 8952 16 haptoglobin haptoglobin NN cord-010119-t1x9gknd 8952 17 , , . cord-010119-t1x9gknd 8953 1 increased increase VBN cord-010119-t1x9gknd 8953 2 lactate lactate NN cord-010119-t1x9gknd 8953 3 dehydrogenase dehydrogenase NN cord-010119-t1x9gknd 8953 4 ( ( -LRB- cord-010119-t1x9gknd 8953 5 LDH LDH NNP cord-010119-t1x9gknd 8953 6 ) ) -RRB- cord-010119-t1x9gknd 8953 7 and and CC cord-010119-t1x9gknd 8953 8 total total JJ cord-010119-t1x9gknd 8953 9 and and CC cord-010119-t1x9gknd 8953 10 indirect indirect JJ cord-010119-t1x9gknd 8953 11 bilirubin bilirubin NN cord-010119-t1x9gknd 8953 12 Results/ Results/ . cord-010119-t1x9gknd 8954 1 Finding finding NN cord-010119-t1x9gknd 8954 2 : : : cord-010119-t1x9gknd 8955 1 The the DT cord-010119-t1x9gknd 8955 2 positive positive JJ cord-010119-t1x9gknd 8955 3 DAT dat NN cord-010119-t1x9gknd 8955 4 in in IN cord-010119-t1x9gknd 8955 5 the the DT cord-010119-t1x9gknd 8955 6 pre pre JJ cord-010119-t1x9gknd 8955 7 - - JJ cord-010119-t1x9gknd 8955 8 transfusion transfusion JJ cord-010119-t1x9gknd 8955 9 sample sample NN cord-010119-t1x9gknd 8955 10 pointed point VBN cord-010119-t1x9gknd 8955 11 to to IN cord-010119-t1x9gknd 8955 12 ongoing ongoing JJ cord-010119-t1x9gknd 8955 13 hemolysis hemolysis NN cord-010119-t1x9gknd 8955 14 prior prior RB cord-010119-t1x9gknd 8955 15 to to IN cord-010119-t1x9gknd 8955 16 the the DT cord-010119-t1x9gknd 8955 17 transfusion transfusion NN cord-010119-t1x9gknd 8955 18 of of IN cord-010119-t1x9gknd 8955 19 the the DT cord-010119-t1x9gknd 8955 20 A A NNP cord-010119-t1x9gknd 8955 21 RBC RBC NNP cord-010119-t1x9gknd 8955 22 unit unit NN cord-010119-t1x9gknd 8955 23 . . . cord-010119-t1x9gknd 8956 1 In in IN cord-010119-t1x9gknd 8956 2 the the DT cord-010119-t1x9gknd 8956 3 setting setting NN cord-010119-t1x9gknd 8956 4 of of IN cord-010119-t1x9gknd 8956 5 recent recent JJ cord-010119-t1x9gknd 8956 6 ABO ABO NNP cord-010119-t1x9gknd 8956 7 - - HYPH cord-010119-t1x9gknd 8956 8 mismatched mismatch VBN cord-010119-t1x9gknd 8956 9 transplant transplant NN cord-010119-t1x9gknd 8956 10 , , , cord-010119-t1x9gknd 8956 11 his -PRON- PRP$ cord-010119-t1x9gknd 8956 12 picture picture NN cord-010119-t1x9gknd 8956 13 was be VBD cord-010119-t1x9gknd 8956 14 consistent consistent JJ cord-010119-t1x9gknd 8956 15 with with IN cord-010119-t1x9gknd 8956 16 hemolysis hemolysis NN cord-010119-t1x9gknd 8956 17 from from IN cord-010119-t1x9gknd 8956 18 newly newly RB cord-010119-t1x9gknd 8956 19 formed form VBN cord-010119-t1x9gknd 8956 20 anti anti JJ cord-010119-t1x9gknd 8956 21 - - JJ cord-010119-t1x9gknd 8956 22 A a NN cord-010119-t1x9gknd 8956 23 by by IN cord-010119-t1x9gknd 8956 24 proliferation proliferation NN cord-010119-t1x9gknd 8956 25 of of IN cord-010119-t1x9gknd 8956 26 donor donor NN cord-010119-t1x9gknd 8956 27 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 8956 28 , , , cord-010119-t1x9gknd 8956 29 or or CC cord-010119-t1x9gknd 8956 30 PLS PLS NNP cord-010119-t1x9gknd 8956 31 . . . cord-010119-t1x9gknd 8957 1 We -PRON- PRP cord-010119-t1x9gknd 8957 2 performed perform VBD cord-010119-t1x9gknd 8957 3 an an DT cord-010119-t1x9gknd 8957 4 emergent emergent JJ cord-010119-t1x9gknd 8957 5 RBC RBC NNP cord-010119-t1x9gknd 8957 6 exchange exchange NN cord-010119-t1x9gknd 8957 7 using use VBG cord-010119-t1x9gknd 8957 8 O o NN cord-010119-t1x9gknd 8957 9 RBCs rbc NNS cord-010119-t1x9gknd 8957 10 with with IN cord-010119-t1x9gknd 8957 11 a a DT cord-010119-t1x9gknd 8957 12 goal goal NN cord-010119-t1x9gknd 8957 13 hematocrit hematocrit NN cord-010119-t1x9gknd 8957 14 of of IN cord-010119-t1x9gknd 8957 15 24 24 CD cord-010119-t1x9gknd 8957 16 % % NN cord-010119-t1x9gknd 8957 17 while while IN cord-010119-t1x9gknd 8957 18 reducing reduce VBG cord-010119-t1x9gknd 8957 19 the the DT cord-010119-t1x9gknd 8957 20 number number NN cord-010119-t1x9gknd 8957 21 of of IN cord-010119-t1x9gknd 8957 22 A a DT cord-010119-t1x9gknd 8957 23 RBCs rbc NNS cord-010119-t1x9gknd 8957 24 in in IN cord-010119-t1x9gknd 8957 25 his -PRON- PRP$ cord-010119-t1x9gknd 8957 26 circulation circulation NN cord-010119-t1x9gknd 8957 27 by by IN cord-010119-t1x9gknd 8957 28 approximately approximately RB cord-010119-t1x9gknd 8957 29 70 70 CD cord-010119-t1x9gknd 8957 30 % % NN cord-010119-t1x9gknd 8957 31 . . . cord-010119-t1x9gknd 8958 1 His -PRON- PRP$ cord-010119-t1x9gknd 8958 2 pain pain NN cord-010119-t1x9gknd 8958 3 improved improve VBD cord-010119-t1x9gknd 8958 4 rapidly rapidly RB cord-010119-t1x9gknd 8958 5 thereafter thereafter RB cord-010119-t1x9gknd 8958 6 , , , cord-010119-t1x9gknd 8958 7 and and CC cord-010119-t1x9gknd 8958 8 he -PRON- PRP cord-010119-t1x9gknd 8958 9 had have VBD cord-010119-t1x9gknd 8958 10 complete complete JJ cord-010119-t1x9gknd 8958 11 recovery recovery NN cord-010119-t1x9gknd 8958 12 of of IN cord-010119-t1x9gknd 8958 13 renal renal JJ cord-010119-t1x9gknd 8958 14 function function NN cord-010119-t1x9gknd 8958 15 . . . cord-010119-t1x9gknd 8959 1 Conclusion conclusion NN cord-010119-t1x9gknd 8959 2 : : : cord-010119-t1x9gknd 8959 3 PLS PLS NNP cord-010119-t1x9gknd 8959 4 should should MD cord-010119-t1x9gknd 8959 5 be be VB cord-010119-t1x9gknd 8959 6 in in IN cord-010119-t1x9gknd 8959 7 the the DT cord-010119-t1x9gknd 8959 8 differential differential JJ cord-010119-t1x9gknd 8959 9 diagnosis diagnosis NN cord-010119-t1x9gknd 8959 10 when when WRB cord-010119-t1x9gknd 8959 11 suspecting/ suspecting/ NNP cord-010119-t1x9gknd 8959 12 investigating investigate VBG cord-010119-t1x9gknd 8959 13 clinically clinically RB cord-010119-t1x9gknd 8959 14 significant significant JJ cord-010119-t1x9gknd 8959 15 hemolysis hemolysis NN cord-010119-t1x9gknd 8959 16 in in IN cord-010119-t1x9gknd 8959 17 ABO ABO NNP cord-010119-t1x9gknd 8959 18 - - HYPH cord-010119-t1x9gknd 8959 19 mismatched mismatch VBN cord-010119-t1x9gknd 8959 20 HPC hpc NN cord-010119-t1x9gknd 8959 21 transplant transplant NN cord-010119-t1x9gknd 8959 22 recipients recipient NNS cord-010119-t1x9gknd 8959 23 , , , cord-010119-t1x9gknd 8959 24 especially especially RB cord-010119-t1x9gknd 8959 25 when when WRB cord-010119-t1x9gknd 8959 26 the the DT cord-010119-t1x9gknd 8959 27 HPC HPC NNP cord-010119-t1x9gknd 8959 28 source source NN cord-010119-t1x9gknd 8959 29 is be VBZ cord-010119-t1x9gknd 8959 30 from from IN cord-010119-t1x9gknd 8959 31 peripheral peripheral JJ cord-010119-t1x9gknd 8959 32 blood blood NN cord-010119-t1x9gknd 8959 33 . . . cord-010119-t1x9gknd 8960 1 As as IN cord-010119-t1x9gknd 8960 2 in in IN cord-010119-t1x9gknd 8960 3 our -PRON- PRP$ cord-010119-t1x9gknd 8960 4 patient patient NN cord-010119-t1x9gknd 8960 5 , , , cord-010119-t1x9gknd 8960 6 it -PRON- PRP cord-010119-t1x9gknd 8960 7 usually usually RB cord-010119-t1x9gknd 8960 8 takes take VBZ cord-010119-t1x9gknd 8960 9 7 7 CD cord-010119-t1x9gknd 8960 10 - - SYM cord-010119-t1x9gknd 8960 11 14 14 CD cord-010119-t1x9gknd 8960 12 days day NNS cord-010119-t1x9gknd 8960 13 for for IN cord-010119-t1x9gknd 8960 14 antibodies antibody NNS cord-010119-t1x9gknd 8960 15 to to TO cord-010119-t1x9gknd 8960 16 develop develop VB cord-010119-t1x9gknd 8960 17 and and CC cord-010119-t1x9gknd 8960 18 they -PRON- PRP cord-010119-t1x9gknd 8960 19 are be VBP cord-010119-t1x9gknd 8960 20 short short RB cord-010119-t1x9gknd 8960 21 - - HYPH cord-010119-t1x9gknd 8960 22 lived live VBN cord-010119-t1x9gknd 8960 23 ( ( -LRB- cord-010119-t1x9gknd 8960 24 3 3 CD cord-010119-t1x9gknd 8960 25 - - SYM cord-010119-t1x9gknd 8960 26 5 5 CD cord-010119-t1x9gknd 8960 27 weeks week NNS cord-010119-t1x9gknd 8960 28 ) ) -RRB- cord-010119-t1x9gknd 8960 29 . . . cord-010119-t1x9gknd 8961 1 Due due IN cord-010119-t1x9gknd 8961 2 to to IN cord-010119-t1x9gknd 8961 3 the the DT cord-010119-t1x9gknd 8961 4 severity severity NN cord-010119-t1x9gknd 8961 5 of of IN cord-010119-t1x9gknd 8961 6 his -PRON- PRP$ cord-010119-t1x9gknd 8961 7 manifestations manifestation NNS cord-010119-t1x9gknd 8961 8 , , , cord-010119-t1x9gknd 8961 9 we -PRON- PRP cord-010119-t1x9gknd 8961 10 performed perform VBD cord-010119-t1x9gknd 8961 11 an an DT cord-010119-t1x9gknd 8961 12 emergent emergent JJ cord-010119-t1x9gknd 8961 13 RBC RBC NNP cord-010119-t1x9gknd 8961 14 exchange exchange NN cord-010119-t1x9gknd 8961 15 successfully successfully RB cord-010119-t1x9gknd 8961 16 . . . cord-010119-t1x9gknd 8962 1 Furthermore furthermore RB cord-010119-t1x9gknd 8962 2 , , , cord-010119-t1x9gknd 8962 3 this this DT cord-010119-t1x9gknd 8962 4 patient patient NN cord-010119-t1x9gknd 8962 5 's 's POS cord-010119-t1x9gknd 8962 6 event event NN cord-010119-t1x9gknd 8962 7 exposed expose VBD cord-010119-t1x9gknd 8962 8 a a DT cord-010119-t1x9gknd 8962 9 vulnerability vulnerability NN cord-010119-t1x9gknd 8962 10 in in IN cord-010119-t1x9gknd 8962 11 our -PRON- PRP$ cord-010119-t1x9gknd 8962 12 system system NN cord-010119-t1x9gknd 8962 13 of of IN cord-010119-t1x9gknd 8962 14 issuing issue VBG cord-010119-t1x9gknd 8962 15 the the DT cord-010119-t1x9gknd 8962 16 proper proper JJ cord-010119-t1x9gknd 8962 17 blood blood NN cord-010119-t1x9gknd 8962 18 type type NN cord-010119-t1x9gknd 8962 19 for for IN cord-010119-t1x9gknd 8962 20 ABO ABO NNP cord-010119-t1x9gknd 8962 21 - - HYPH cord-010119-t1x9gknd 8962 22 mismatched mismatch VBN cord-010119-t1x9gknd 8962 23 transplant transplant NN cord-010119-t1x9gknd 8962 24 recipients recipient NNS cord-010119-t1x9gknd 8962 25 , , , cord-010119-t1x9gknd 8962 26 which which WDT cord-010119-t1x9gknd 8962 27 has have VBZ cord-010119-t1x9gknd 8962 28 since since IN cord-010119-t1x9gknd 8962 29 been be VBN cord-010119-t1x9gknd 8962 30 remediated remediate VBN cord-010119-t1x9gknd 8962 31 electronically electronically RB cord-010119-t1x9gknd 8962 32 Background Background NNP cord-010119-t1x9gknd 8962 33 / / SYM cord-010119-t1x9gknd 8962 34 Case Case NNP cord-010119-t1x9gknd 8962 35 Studies Studies NNPS cord-010119-t1x9gknd 8962 36 : : : cord-010119-t1x9gknd 8963 1 Group group NN cord-010119-t1x9gknd 8963 2 O o NN cord-010119-t1x9gknd 8963 3 RhD rhd NN cord-010119-t1x9gknd 8963 4 negative negative JJ cord-010119-t1x9gknd 8963 5 ( ( -LRB- cord-010119-t1x9gknd 8963 6 ONEG ONEG NNP cord-010119-t1x9gknd 8963 7 ) ) -RRB- cord-010119-t1x9gknd 8963 8 red red JJ cord-010119-t1x9gknd 8963 9 blood blood NN cord-010119-t1x9gknd 8963 10 cells cell NNS cord-010119-t1x9gknd 8963 11 ( ( -LRB- cord-010119-t1x9gknd 8963 12 RBCs rbc NNS cord-010119-t1x9gknd 8963 13 ) ) -RRB- cord-010119-t1x9gknd 8963 14 are be VBP cord-010119-t1x9gknd 8963 15 a a DT cord-010119-t1x9gknd 8963 16 precious precious JJ cord-010119-t1x9gknd 8963 17 resource resource NN cord-010119-t1x9gknd 8963 18 . . . cord-010119-t1x9gknd 8964 1 To to TO cord-010119-t1x9gknd 8964 2 conserve conserve VB cord-010119-t1x9gknd 8964 3 the the DT cord-010119-t1x9gknd 8964 4 ONEG ONEG NNP cord-010119-t1x9gknd 8964 5 inventory inventory NN cord-010119-t1x9gknd 8964 6 while while IN cord-010119-t1x9gknd 8964 7 minimizing minimize VBG cord-010119-t1x9gknd 8964 8 the the DT cord-010119-t1x9gknd 8964 9 risk risk NN cord-010119-t1x9gknd 8964 10 of of IN cord-010119-t1x9gknd 8964 11 RhD RhD NNP cord-010119-t1x9gknd 8964 12 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8964 13 in in IN cord-010119-t1x9gknd 8964 14 ONEG ONEG NNP cord-010119-t1x9gknd 8964 15 females female NNS cord-010119-t1x9gknd 8964 16 of of IN cord-010119-t1x9gknd 8964 17 childbearing childbeare VBG cord-010119-t1x9gknd 8964 18 age age NN cord-010119-t1x9gknd 8964 19 , , , cord-010119-t1x9gknd 8964 20 transfusion transfusion NN cord-010119-t1x9gknd 8964 21 services service NNS cord-010119-t1x9gknd 8964 22 may may MD cord-010119-t1x9gknd 8964 23 automatically automatically RB cord-010119-t1x9gknd 8964 24 provide provide VB cord-010119-t1x9gknd 8964 25 group group NN cord-010119-t1x9gknd 8964 26 O o UH cord-010119-t1x9gknd 8964 27 RhD rhd NN cord-010119-t1x9gknd 8964 28 positive positive JJ cord-010119-t1x9gknd 8964 29 ( ( -LRB- cord-010119-t1x9gknd 8964 30 OPOS OPOS NNP cord-010119-t1x9gknd 8964 31 ) ) -RRB- cord-010119-t1x9gknd 8964 32 RBCs rbc NNS cord-010119-t1x9gknd 8964 33 to to TO cord-010119-t1x9gknd 8964 34 RhD rhd VB cord-010119-t1x9gknd 8964 35 negative negative JJ cord-010119-t1x9gknd 8964 36 males male NNS cord-010119-t1x9gknd 8965 1 and/or and/or CC cord-010119-t1x9gknd 8965 2 RhD RhD NNP cord-010119-t1x9gknd 8965 3 negative negative JJ cord-010119-t1x9gknd 8965 4 postmenopausal postmenopausal JJ cord-010119-t1x9gknd 8965 5 females female NNS cord-010119-t1x9gknd 8965 6 during during IN cord-010119-t1x9gknd 8965 7 bleeding bleed VBG cord-010119-t1x9gknd 8965 8 emergencies emergency NNS cord-010119-t1x9gknd 8965 9 . . . cord-010119-t1x9gknd 8966 1 Despite despite IN cord-010119-t1x9gknd 8966 2 these these DT cord-010119-t1x9gknd 8966 3 conservation conservation NN cord-010119-t1x9gknd 8966 4 strategies strategy NNS cord-010119-t1x9gknd 8966 5 , , , cord-010119-t1x9gknd 8966 6 shortages shortage NNS cord-010119-t1x9gknd 8966 7 of of IN cord-010119-t1x9gknd 8966 8 ONEG ONEG NNP cord-010119-t1x9gknd 8966 9 RBCs rbc NNS cord-010119-t1x9gknd 8966 10 occur occur VBP cord-010119-t1x9gknd 8966 11 . . . cord-010119-t1x9gknd 8967 1 The the DT cord-010119-t1x9gknd 8967 2 goal goal NN cord-010119-t1x9gknd 8967 3 of of IN cord-010119-t1x9gknd 8967 4 this this DT cord-010119-t1x9gknd 8967 5 study study NN cord-010119-t1x9gknd 8967 6 was be VBD cord-010119-t1x9gknd 8967 7 to to TO cord-010119-t1x9gknd 8967 8 determine determine VB cord-010119-t1x9gknd 8967 9 how how WRB cord-010119-t1x9gknd 8967 10 the the DT cord-010119-t1x9gknd 8967 11 utilization utilization NN cord-010119-t1x9gknd 8967 12 of of IN cord-010119-t1x9gknd 8967 13 ONEG ONEG NNP cord-010119-t1x9gknd 8967 14 RBCs rbc NNS cord-010119-t1x9gknd 8967 15 can can MD cord-010119-t1x9gknd 8967 16 be be VB cord-010119-t1x9gknd 8967 17 optimized optimize VBN cord-010119-t1x9gknd 8967 18 using use VBG cord-010119-t1x9gknd 8967 19 agebased agebase VBN cord-010119-t1x9gknd 8967 20 OPOS OPOS NNP cord-010119-t1x9gknd 8967 21 switching switch VBG cord-010119-t1x9gknd 8967 22 for for IN cord-010119-t1x9gknd 8967 23 routine routine JJ cord-010119-t1x9gknd 8967 24 transfusions transfusion NNS cord-010119-t1x9gknd 8967 25 in in IN cord-010119-t1x9gknd 8967 26 ONEG ONEG NNP cord-010119-t1x9gknd 8967 27 patients patient NNS cord-010119-t1x9gknd 8967 28 . . . cord-010119-t1x9gknd 8968 1 Study Study NNP cord-010119-t1x9gknd 8968 2 Design Design NNP cord-010119-t1x9gknd 8968 3 / / SYM cord-010119-t1x9gknd 8968 4 Methods method NNS cord-010119-t1x9gknd 8968 5 : : : cord-010119-t1x9gknd 8969 1 Recipient recipient NN cord-010119-t1x9gknd 8969 2 age age NN cord-010119-t1x9gknd 8969 3 and and CC cord-010119-t1x9gknd 8969 4 ABO ABO NNP cord-010119-t1x9gknd 8969 5 / / SYM cord-010119-t1x9gknd 8969 6 RhD RhD NNP cord-010119-t1x9gknd 8969 7 group group NN cord-010119-t1x9gknd 8969 8 were be VBD cord-010119-t1x9gknd 8969 9 obtained obtain VBN cord-010119-t1x9gknd 8969 10 for for IN cord-010119-t1x9gknd 8969 11 all all DT cord-010119-t1x9gknd 8969 12 allogeneic allogeneic JJ cord-010119-t1x9gknd 8969 13 RBC RBC NNP cord-010119-t1x9gknd 8969 14 transfusions transfusion NNS cord-010119-t1x9gknd 8969 15 during during IN cord-010119-t1x9gknd 8969 16 the the DT cord-010119-t1x9gknd 8969 17 2016 2016 CD cord-010119-t1x9gknd 8969 18 calendar calendar NN cord-010119-t1x9gknd 8969 19 year year NN cord-010119-t1x9gknd 8969 20 from from IN cord-010119-t1x9gknd 8969 21 9 9 CD cord-010119-t1x9gknd 8969 22 hospitals hospital NNS cord-010119-t1x9gknd 8969 23 . . . cord-010119-t1x9gknd 8970 1 An an DT cord-010119-t1x9gknd 8970 2 additional additional JJ cord-010119-t1x9gknd 8970 3 hospital hospital NN cord-010119-t1x9gknd 8970 4 * * NFP cord-010119-t1x9gknd 8970 5 provided provide VBD cord-010119-t1x9gknd 8970 6 data datum NNS cord-010119-t1x9gknd 8970 7 for for IN cord-010119-t1x9gknd 8970 8 August August NNP cord-010119-t1x9gknd 8970 9 - - HYPH cord-010119-t1x9gknd 8970 10 December December NNP cord-010119-t1x9gknd 8970 11 2016 2016 CD cord-010119-t1x9gknd 8970 12 . . . cord-010119-t1x9gknd 8971 1 RBC RBC NNP cord-010119-t1x9gknd 8971 2 transfusions transfusion NNS cord-010119-t1x9gknd 8971 3 in in IN cord-010119-t1x9gknd 8971 4 patients patient NNS cord-010119-t1x9gknd 8971 5 < < NNP cord-010119-t1x9gknd 8971 6 1 1 CD cord-010119-t1x9gknd 8971 7 year year NN cord-010119-t1x9gknd 8971 8 of of IN cord-010119-t1x9gknd 8971 9 age age NN cord-010119-t1x9gknd 8971 10 , , , cord-010119-t1x9gknd 8971 11 and and CC cord-010119-t1x9gknd 8971 12 in in IN cord-010119-t1x9gknd 8971 13 patients patient NNS cord-010119-t1x9gknd 8971 14 whose whose WP$ cord-010119-t1x9gknd 8971 15 age age NN cord-010119-t1x9gknd 8971 16 and/ and/ NNP cord-010119-t1x9gknd 8971 17 or or CC cord-010119-t1x9gknd 8971 18 ABO ABO NNP cord-010119-t1x9gknd 8971 19 group group NN cord-010119-t1x9gknd 8971 20 were be VBD cord-010119-t1x9gknd 8971 21 unknown unknown JJ cord-010119-t1x9gknd 8971 22 , , , cord-010119-t1x9gknd 8971 23 were be VBD cord-010119-t1x9gknd 8971 24 excluded exclude VBN cord-010119-t1x9gknd 8971 25 from from IN cord-010119-t1x9gknd 8971 26 analysis analysis NN cord-010119-t1x9gknd 8971 27 . . . cord-010119-t1x9gknd 8972 1 The the DT cord-010119-t1x9gknd 8972 2 ABO ABO NNP cord-010119-t1x9gknd 8972 3 / / SYM cord-010119-t1x9gknd 8972 4 RhD rhd NN cord-010119-t1x9gknd 8972 5 group group NN cord-010119-t1x9gknd 8972 6 of of IN cord-010119-t1x9gknd 8972 7 each each DT cord-010119-t1x9gknd 8972 8 RBC RBC NNP cord-010119-t1x9gknd 8972 9 unit unit NN cord-010119-t1x9gknd 8972 10 was be VBD cord-010119-t1x9gknd 8972 11 compared compare VBN cord-010119-t1x9gknd 8972 12 to to IN cord-010119-t1x9gknd 8972 13 that that DT cord-010119-t1x9gknd 8972 14 of of IN cord-010119-t1x9gknd 8972 15 the the DT cord-010119-t1x9gknd 8972 16 recipient recipient NN cord-010119-t1x9gknd 8972 17 to to TO cord-010119-t1x9gknd 8972 18 determine determine VB cord-010119-t1x9gknd 8972 19 the the DT cord-010119-t1x9gknd 8972 20 number number NN cord-010119-t1x9gknd 8972 21 of of IN cord-010119-t1x9gknd 8972 22 ONEG ONEG NNP cord-010119-t1x9gknd 8972 23 RBCs rbc NNS cord-010119-t1x9gknd 8972 24 transfused transfuse VBN cord-010119-t1x9gknd 8972 25 to to IN cord-010119-t1x9gknd 8972 26 all all DT cord-010119-t1x9gknd 8972 27 patients patient NNS cord-010119-t1x9gknd 8972 28 , , , cord-010119-t1x9gknd 8972 29 the the DT cord-010119-t1x9gknd 8972 30 number number NN cord-010119-t1x9gknd 8972 31 of of IN cord-010119-t1x9gknd 8972 32 RBCs rbc NNS cord-010119-t1x9gknd 8972 33 transfused transfuse VBN cord-010119-t1x9gknd 8972 34 to to IN cord-010119-t1x9gknd 8972 35 ONEG ONEG NNP cord-010119-t1x9gknd 8972 36 patients patient NNS cord-010119-t1x9gknd 8972 37 and and CC cord-010119-t1x9gknd 8972 38 the the DT cord-010119-t1x9gknd 8972 39 number number NN cord-010119-t1x9gknd 8972 40 of of IN cord-010119-t1x9gknd 8972 41 ONEG ONEG NNP cord-010119-t1x9gknd 8972 42 RBCs rbc NNS cord-010119-t1x9gknd 8972 43 transfused transfuse VBN cord-010119-t1x9gknd 8972 44 to to IN cord-010119-t1x9gknd 8972 45 ONEG ONEG NNP cord-010119-t1x9gknd 8972 46 patients patient NNS cord-010119-t1x9gknd 8972 47 . . . cord-010119-t1x9gknd 8973 1 The the DT cord-010119-t1x9gknd 8973 2 number number NN cord-010119-t1x9gknd 8973 3 of of IN cord-010119-t1x9gknd 8973 4 ONEG ONEG NNP cord-010119-t1x9gknd 8973 5 RBCs rbc NNS cord-010119-t1x9gknd 8973 6 transfused transfuse VBN cord-010119-t1x9gknd 8973 7 specifically specifically RB cord-010119-t1x9gknd 8973 8 to to IN cord-010119-t1x9gknd 8973 9 ONEG ONEG NNP cord-010119-t1x9gknd 8973 10 patients patient NNS cord-010119-t1x9gknd 8974 1 > > XX cord-010119-t1x9gknd 8974 2 /5 /5 . cord-010119-t1x9gknd 8975 1 70 70 CD cord-010119-t1x9gknd 8975 2 years year NNS cord-010119-t1x9gknd 8975 3 was be VBD cord-010119-t1x9gknd 8975 4 also also RB cord-010119-t1x9gknd 8975 5 determined determine VBN cord-010119-t1x9gknd 8975 6 . . . cord-010119-t1x9gknd 8976 1 Results result NNS cord-010119-t1x9gknd 8976 2 / / SYM cord-010119-t1x9gknd 8976 3 Findings finding NNS cord-010119-t1x9gknd 8976 4 : : : cord-010119-t1x9gknd 8976 5 See see VB cord-010119-t1x9gknd 8976 6 table table NN cord-010119-t1x9gknd 8976 7 1 1 CD cord-010119-t1x9gknd 8976 8 . . . cord-010119-t1x9gknd 8977 1 The the DT cord-010119-t1x9gknd 8977 2 fraction fraction NN cord-010119-t1x9gknd 8977 3 of of IN cord-010119-t1x9gknd 8977 4 all all DT cord-010119-t1x9gknd 8977 5 transfused transfuse VBN cord-010119-t1x9gknd 8977 6 RBCs rbc NNS cord-010119-t1x9gknd 8977 7 that that WDT cord-010119-t1x9gknd 8977 8 were be VBD cord-010119-t1x9gknd 8977 9 ONEG ONEG NNP cord-010119-t1x9gknd 8977 10 ranged range VBN cord-010119-t1x9gknd 8977 11 from from IN cord-010119-t1x9gknd 8977 12 5 5 CD cord-010119-t1x9gknd 8977 13 - - SYM cord-010119-t1x9gknd 8977 14 14 14 CD cord-010119-t1x9gknd 8977 15 % % NN cord-010119-t1x9gknd 8977 16 ( ( -LRB- cord-010119-t1x9gknd 8977 17 row row NN cord-010119-t1x9gknd 8977 18 F F NNP cord-010119-t1x9gknd 8977 19 ) ) -RRB- cord-010119-t1x9gknd 8977 20 . . . cord-010119-t1x9gknd 8978 1 The the DT cord-010119-t1x9gknd 8978 2 percentage percentage NN cord-010119-t1x9gknd 8978 3 of of IN cord-010119-t1x9gknd 8978 4 ONEG ONEG NNP cord-010119-t1x9gknd 8978 5 RBCs rbc NNS cord-010119-t1x9gknd 8978 6 transfused transfuse VBN cord-010119-t1x9gknd 8978 7 to to IN cord-010119-t1x9gknd 8978 8 ONEG ONEG NNP cord-010119-t1x9gknd 8978 9 patients patient NNS cord-010119-t1x9gknd 8978 10 ranged range VBD cord-010119-t1x9gknd 8978 11 from from IN cord-010119-t1x9gknd 8978 12 37 37 CD cord-010119-t1x9gknd 8978 13 - - SYM cord-010119-t1x9gknd 8978 14 89 89 CD cord-010119-t1x9gknd 8978 15 % % NN cord-010119-t1x9gknd 8978 16 ( ( -LRB- cord-010119-t1x9gknd 8978 17 row row NN cord-010119-t1x9gknd 8978 18 G g NN cord-010119-t1x9gknd 8978 19 ) ) -RRB- cord-010119-t1x9gknd 8978 20 ; ; : cord-010119-t1x9gknd 8978 21 thus thus RB cord-010119-t1x9gknd 8978 22 , , , cord-010119-t1x9gknd 8978 23 NON NON NNP cord-010119-t1x9gknd 8978 24 - - JJ cord-010119-t1x9gknd 8978 25 ONEG ONEG NNP cord-010119-t1x9gknd 8978 26 patients patient NNS cord-010119-t1x9gknd 8978 27 received receive VBD cord-010119-t1x9gknd 8978 28 11 11 CD cord-010119-t1x9gknd 8978 29 - - SYM cord-010119-t1x9gknd 8978 30 63 63 CD cord-010119-t1x9gknd 8978 31 % % NN cord-010119-t1x9gknd 8978 32 of of IN cord-010119-t1x9gknd 8978 33 the the DT cord-010119-t1x9gknd 8978 34 ONEG ONEG NNP cord-010119-t1x9gknd 8978 35 units unit NNS cord-010119-t1x9gknd 8978 36 transfused transfuse VBN cord-010119-t1x9gknd 8978 37 ( ( -LRB- cord-010119-t1x9gknd 8978 38 row row NN cord-010119-t1x9gknd 8978 39 H H NNP cord-010119-t1x9gknd 8978 40 ) ) -RRB- cord-010119-t1x9gknd 8978 41 . . . cord-010119-t1x9gknd 8979 1 Hospitals hospital NNS cord-010119-t1x9gknd 8979 2 differed differ VBD cord-010119-t1x9gknd 8979 3 widely widely RB cord-010119-t1x9gknd 8979 4 in in IN cord-010119-t1x9gknd 8979 5 the the DT cord-010119-t1x9gknd 8979 6 practice practice NN cord-010119-t1x9gknd 8979 7 of of IN cord-010119-t1x9gknd 8979 8 issuing issue VBG cord-010119-t1x9gknd 8979 9 ONEG ONEG NNP cord-010119-t1x9gknd 8979 10 RBCs rbc NNS cord-010119-t1x9gknd 8979 11 to to IN cord-010119-t1x9gknd 8979 12 ONEG ONEG NNP cord-010119-t1x9gknd 8979 13 patients patient NNS cord-010119-t1x9gknd 8979 14 ( ( -LRB- cord-010119-t1x9gknd 8979 15 68%-100 68%-100 CD cord-010119-t1x9gknd 8979 16 % % NN cord-010119-t1x9gknd 8979 17 ; ; , cord-010119-t1x9gknd 8979 18 row row NN cord-010119-t1x9gknd 8979 19 I -PRON- PRP cord-010119-t1x9gknd 8979 20 ) ) -RRB- cord-010119-t1x9gknd 8979 21 . . . cord-010119-t1x9gknd 8980 1 Overall overall JJ cord-010119-t1x9gknd 8980 2 use use NN cord-010119-t1x9gknd 8980 3 of of IN cord-010119-t1x9gknd 8980 4 ONEG ONEG NNP cord-010119-t1x9gknd 8980 5 RBCs rbc NNS cord-010119-t1x9gknd 8980 6 could could MD cord-010119-t1x9gknd 8980 7 have have VB cord-010119-t1x9gknd 8980 8 been be VBN cord-010119-t1x9gknd 8980 9 reduced reduce VBN cord-010119-t1x9gknd 8980 10 by by IN cord-010119-t1x9gknd 8980 11 10%-39 10%-39 CD cord-010119-t1x9gknd 8980 12 % % NN cord-010119-t1x9gknd 8980 13 if if IN cord-010119-t1x9gknd 8980 14 OPOS OPOS NNP cord-010119-t1x9gknd 8980 15 units unit NNS cord-010119-t1x9gknd 8980 16 had have VBD cord-010119-t1x9gknd 8980 17 been be VBN cord-010119-t1x9gknd 8980 18 given give VBN cord-010119-t1x9gknd 8980 19 to to IN cord-010119-t1x9gknd 8980 20 all all DT cord-010119-t1x9gknd 8980 21 ONEG ONEG NNP cord-010119-t1x9gknd 8980 22 patients patient NNS cord-010119-t1x9gknd 8980 23 > > XX cord-010119-t1x9gknd 8980 24 / / SYM cord-010119-t1x9gknd 8980 25 5 5 CD cord-010119-t1x9gknd 8980 26 70 70 CD cord-010119-t1x9gknd 8980 27 years year NNS cord-010119-t1x9gknd 8980 28 old old JJ cord-010119-t1x9gknd 8980 29 ( ( -LRB- cord-010119-t1x9gknd 8980 30 row row NN cord-010119-t1x9gknd 8980 31 J J NNP cord-010119-t1x9gknd 8980 32 ) ) -RRB- cord-010119-t1x9gknd 8980 33 . . . cord-010119-t1x9gknd 8981 1 Conclusion conclusion NN cord-010119-t1x9gknd 8981 2 : : : cord-010119-t1x9gknd 8981 3 During during IN cord-010119-t1x9gknd 8981 4 times time NNS cord-010119-t1x9gknd 8981 5 of of IN cord-010119-t1x9gknd 8981 6 ONEG ONEG NNP cord-010119-t1x9gknd 8981 7 shortage shortage NN cord-010119-t1x9gknd 8981 8 , , , cord-010119-t1x9gknd 8981 9 age age NN cord-010119-t1x9gknd 8981 10 based base VBN cord-010119-t1x9gknd 8981 11 OPOS OPOS NNP cord-010119-t1x9gknd 8981 12 switching switching NN cord-010119-t1x9gknd 8981 13 rules rule NNS cord-010119-t1x9gknd 8981 14 may may MD cord-010119-t1x9gknd 8981 15 be be VB cord-010119-t1x9gknd 8981 16 applied apply VBN cord-010119-t1x9gknd 8981 17 for for IN cord-010119-t1x9gknd 8981 18 routine routine JJ cord-010119-t1x9gknd 8981 19 transfusions transfusion NNS cord-010119-t1x9gknd 8981 20 . . . cord-010119-t1x9gknd 8982 1 This this DT cord-010119-t1x9gknd 8982 2 would would MD cord-010119-t1x9gknd 8982 3 help help VB cord-010119-t1x9gknd 8982 4 to to TO cord-010119-t1x9gknd 8982 5 ensure ensure VB cord-010119-t1x9gknd 8982 6 the the DT cord-010119-t1x9gknd 8982 7 availability availability NN cord-010119-t1x9gknd 8982 8 of of IN cord-010119-t1x9gknd 8982 9 ONEG ONEG NNP cord-010119-t1x9gknd 8982 10 RBC RBC NNP cord-010119-t1x9gknd 8982 11 units unit NNS cord-010119-t1x9gknd 8982 12 for for IN cord-010119-t1x9gknd 8982 13 ONEG ONEG NNP cord-010119-t1x9gknd 8982 14 females female NNS cord-010119-t1x9gknd 8982 15 of of IN cord-010119-t1x9gknd 8982 16 childbearing childbeare VBG cord-010119-t1x9gknd 8982 17 age age NN cord-010119-t1x9gknd 8982 18 . . . cord-010119-t1x9gknd 8983 1 Rasha Rasha NNP cord-010119-t1x9gknd 8983 2 Eldeeb Eldeeb NNP cord-010119-t1x9gknd 8983 3 Mohammed Mohammed NNP cord-010119-t1x9gknd 8983 4 * * NFP cord-010119-t1x9gknd 8983 5 1 1 CD cord-010119-t1x9gknd 8983 6 , , , cord-010119-t1x9gknd 8983 7 Nehad Nehad NNP cord-010119-t1x9gknd 8983 8 Mohammed Mohammed NNP cord-010119-t1x9gknd 8983 9 2 2 CD cord-010119-t1x9gknd 8983 10 , , , cord-010119-t1x9gknd 8983 11 Marwa Marwa NNP cord-010119-t1x9gknd 8983 12 Aly Aly NNP cord-010119-t1x9gknd 8983 13 2 2 CD cord-010119-t1x9gknd 8983 14 and and CC cord-010119-t1x9gknd 8983 15 Nashwa Nashwa NNP cord-010119-t1x9gknd 8983 16 Fahmy Fahmy NNP cord-010119-t1x9gknd 8983 17 2 2 CD cord-010119-t1x9gknd 8983 18 . . . cord-010119-t1x9gknd 8984 1 1 1 LS cord-010119-t1x9gknd 8984 2 National National NNP cord-010119-t1x9gknd 8984 3 Blood Blood NNP cord-010119-t1x9gknd 8984 4 Transfusion Transfusion NNP cord-010119-t1x9gknd 8984 5 Services Services NNPS cord-010119-t1x9gknd 8984 6 , , , cord-010119-t1x9gknd 8984 7 2 2 CD cord-010119-t1x9gknd 8984 8 NBTS NBTS NNP cord-010119-t1x9gknd 8984 9 Background Background NNP cord-010119-t1x9gknd 8984 10 / / SYM cord-010119-t1x9gknd 8984 11 Case Case NNP cord-010119-t1x9gknd 8984 12 Studies Studies NNPS cord-010119-t1x9gknd 8984 13 : : : cord-010119-t1x9gknd 8984 14 Sensitization sensitization NN cord-010119-t1x9gknd 8984 15 to to IN cord-010119-t1x9gknd 8984 16 the the DT cord-010119-t1x9gknd 8984 17 transfused transfuse VBN cord-010119-t1x9gknd 8984 18 red red JJ cord-010119-t1x9gknd 8984 19 cell cell NN cord-010119-t1x9gknd 8984 20 may may MD cord-010119-t1x9gknd 8984 21 complicate complicate VB cord-010119-t1x9gknd 8984 22 further further JJ cord-010119-t1x9gknd 8984 23 transfusion transfusion NN cord-010119-t1x9gknd 8984 24 & & CC cord-010119-t1x9gknd 8984 25 make make VB cord-010119-t1x9gknd 8984 26 it -PRON- PRP cord-010119-t1x9gknd 8984 27 increasingly increasingly RB cord-010119-t1x9gknd 8984 28 difficult difficult JJ cord-010119-t1x9gknd 8984 29 to to TO cord-010119-t1x9gknd 8984 30 find find VB cord-010119-t1x9gknd 8984 31 compatible compatible JJ cord-010119-t1x9gknd 8984 32 blood blood NN cord-010119-t1x9gknd 8984 33 components component NNS cord-010119-t1x9gknd 8984 34 for for IN cord-010119-t1x9gknd 8984 35 those those DT cord-010119-t1x9gknd 8984 36 patients patient NNS cord-010119-t1x9gknd 8984 37 . . . cord-010119-t1x9gknd 8985 1 Splenectomy Splenectomy NNP cord-010119-t1x9gknd 8985 2 has have VBZ cord-010119-t1x9gknd 8985 3 been be VBN cord-010119-t1x9gknd 8985 4 shown show VBN cord-010119-t1x9gknd 8985 5 to to TO cord-010119-t1x9gknd 8985 6 increase increase VB cord-010119-t1x9gknd 8985 7 human human JJ cord-010119-t1x9gknd 8985 8 leucocyte leucocyte NNP cord-010119-t1x9gknd 8985 9 antigen antigen NN cord-010119-t1x9gknd 8985 10 immunization immunization NN cord-010119-t1x9gknd 8985 11 . . . cord-010119-t1x9gknd 8986 1 The the DT cord-010119-t1x9gknd 8986 2 aim aim NN cord-010119-t1x9gknd 8986 3 of of IN cord-010119-t1x9gknd 8986 4 the the DT cord-010119-t1x9gknd 8986 5 study study NN cord-010119-t1x9gknd 8986 6 is be VBZ cord-010119-t1x9gknd 8986 7 to to TO cord-010119-t1x9gknd 8986 8 evaluated evaluate VBN cord-010119-t1x9gknd 8986 9 the the DT cord-010119-t1x9gknd 8986 10 effect effect NN cord-010119-t1x9gknd 8986 11 of of IN cord-010119-t1x9gknd 8986 12 splenectomy splenectomy NN cord-010119-t1x9gknd 8986 13 on on IN cord-010119-t1x9gknd 8986 14 the the DT cord-010119-t1x9gknd 8986 15 occurrence occurrence NN cord-010119-t1x9gknd 8986 16 of of IN cord-010119-t1x9gknd 8986 17 red red JJ cord-010119-t1x9gknd 8986 18 cell cell NN cord-010119-t1x9gknd 8986 19 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8986 20 in in IN cord-010119-t1x9gknd 8986 21 humans human NNS cord-010119-t1x9gknd 8986 22 . . . cord-010119-t1x9gknd 8987 1 Study Study NNP cord-010119-t1x9gknd 8987 2 Design Design NNP cord-010119-t1x9gknd 8987 3 / / SYM cord-010119-t1x9gknd 8987 4 Method method NN cord-010119-t1x9gknd 8987 5 : : : cord-010119-t1x9gknd 8988 1 This this DT cord-010119-t1x9gknd 8988 2 study study NN cord-010119-t1x9gknd 8988 3 was be VBD cord-010119-t1x9gknd 8988 4 conducted conduct VBN cord-010119-t1x9gknd 8988 5 on on IN cord-010119-t1x9gknd 8988 6 206 206 CD cord-010119-t1x9gknd 8988 7 multitransfused multitransfuse VBN cord-010119-t1x9gknd 8988 8 patients patient NNS cord-010119-t1x9gknd 8988 9 who who WP cord-010119-t1x9gknd 8988 10 received receive VBD cord-010119-t1x9gknd 8988 11 blood blood NN cord-010119-t1x9gknd 8988 12 transfusion transfusion NN cord-010119-t1x9gknd 8988 13 chronically chronically RB cord-010119-t1x9gknd 8988 14 at at IN cord-010119-t1x9gknd 8988 15 our -PRON- PRP$ cord-010119-t1x9gknd 8988 16 central central JJ cord-010119-t1x9gknd 8988 17 blood blood NN cord-010119-t1x9gknd 8988 18 center center NN cord-010119-t1x9gknd 8988 19 . . . cord-010119-t1x9gknd 8989 1 They -PRON- PRP cord-010119-t1x9gknd 8989 2 were be VBD cord-010119-t1x9gknd 8989 3 129 129 CD cord-010119-t1x9gknd 8989 4 thalassemia thalassemia NN cord-010119-t1x9gknd 8989 5 patients patient NNS cord-010119-t1x9gknd 8989 6 ( ( -LRB- cord-010119-t1x9gknd 8989 7 128 128 CD cord-010119-t1x9gknd 8989 8 bthalassemia bthalassemia NN cord-010119-t1x9gknd 8989 9 patients patient NNS cord-010119-t1x9gknd 8989 10 , , , cord-010119-t1x9gknd 8989 11 one one CD cord-010119-t1x9gknd 8989 12 patients patient NNS cord-010119-t1x9gknd 8989 13 with with IN cord-010119-t1x9gknd 8989 14 a a DT cord-010119-t1x9gknd 8989 15 thalassemia thalassemia NN cord-010119-t1x9gknd 8989 16 ) ) -RRB- cord-010119-t1x9gknd 8989 17 , , , cord-010119-t1x9gknd 8989 18 10 10 CD cord-010119-t1x9gknd 8989 19 sickle sickle NN cord-010119-t1x9gknd 8989 20 cell cell NN cord-010119-t1x9gknd 8989 21 anemia anemia NN cord-010119-t1x9gknd 8989 22 patients patient NNS cord-010119-t1x9gknd 8989 23 and and CC cord-010119-t1x9gknd 8989 24 6 6 CD cord-010119-t1x9gknd 8989 25 immune immune JJ cord-010119-t1x9gknd 8989 26 hemolytic hemolytic JJ cord-010119-t1x9gknd 8989 27 anemia anemia NN cord-010119-t1x9gknd 8989 28 patients patient NNS cord-010119-t1x9gknd 8989 29 ( ( -LRB- cord-010119-t1x9gknd 8989 30 4 4 CD cord-010119-t1x9gknd 8989 31 auto auto NN cord-010119-t1x9gknd 8989 32 immune immune JJ cord-010119-t1x9gknd 8989 33 hemolytic hemolytic JJ cord-010119-t1x9gknd 8989 34 anemia anemia NN cord-010119-t1x9gknd 8989 35 patients patient NNS cord-010119-t1x9gknd 8989 36 , , , cord-010119-t1x9gknd 8989 37 one one CD cord-010119-t1x9gknd 8989 38 paroxysmal paroxysmal JJ cord-010119-t1x9gknd 8989 39 nocturnal nocturnal JJ cord-010119-t1x9gknd 8989 40 hemoglobinemia hemoglobinemia NN cord-010119-t1x9gknd 8989 41 patient patient NN cord-010119-t1x9gknd 8989 42 , , , cord-010119-t1x9gknd 8989 43 one one CD cord-010119-t1x9gknd 8989 44 immune immune JJ cord-010119-t1x9gknd 8989 45 thrombocytopenic thrombocytopenic JJ cord-010119-t1x9gknd 8989 46 purpra purpra IN cord-010119-t1x9gknd 8989 47 patients patient NNS cord-010119-t1x9gknd 8989 48 ) ) -RRB- cord-010119-t1x9gknd 8989 49 . . . cord-010119-t1x9gknd 8990 1 29 29 CD cord-010119-t1x9gknd 8990 2 Oncology Oncology NNP cord-010119-t1x9gknd 8990 3 patients patient NNS cord-010119-t1x9gknd 8990 4 , , , cord-010119-t1x9gknd 8990 5 32 32 CD cord-010119-t1x9gknd 8990 6 Chronic chronic JJ cord-010119-t1x9gknd 8990 7 diseases disease NNS cord-010119-t1x9gknd 8990 8 patients patient NNS cord-010119-t1x9gknd 8990 9 . . . cord-010119-t1x9gknd 8991 1 History history NN cord-010119-t1x9gknd 8991 2 and and CC cord-010119-t1x9gknd 8991 3 demographic demographic JJ cord-010119-t1x9gknd 8991 4 data datum NNS cord-010119-t1x9gknd 8991 5 were be VBD cord-010119-t1x9gknd 8991 6 documented document VBN cord-010119-t1x9gknd 8991 7 . . . cord-010119-t1x9gknd 8992 1 All all PDT cord-010119-t1x9gknd 8992 2 the the DT cord-010119-t1x9gknd 8992 3 patients patient NNS cord-010119-t1x9gknd 8992 4 who who WP cord-010119-t1x9gknd 8992 5 received receive VBD cord-010119-t1x9gknd 8992 6 blood blood NN cord-010119-t1x9gknd 8992 7 are be VBP cord-010119-t1x9gknd 8992 8 examined examine VBN cord-010119-t1x9gknd 8992 9 for for IN cord-010119-t1x9gknd 8992 10 the the DT cord-010119-t1x9gknd 8992 11 presence presence NN cord-010119-t1x9gknd 8992 12 of of IN cord-010119-t1x9gknd 8992 13 the the DT cord-010119-t1x9gknd 8992 14 spleen spleen NN cord-010119-t1x9gknd 8992 15 . . . cord-010119-t1x9gknd 8993 1 Our -PRON- PRP$ cord-010119-t1x9gknd 8993 2 patients patient NNS cord-010119-t1x9gknd 8993 3 were be VBD cord-010119-t1x9gknd 8993 4 subjected subject VBN cord-010119-t1x9gknd 8993 5 to to IN cord-010119-t1x9gknd 8993 6 Direct Direct NNP cord-010119-t1x9gknd 8993 7 & & CC cord-010119-t1x9gknd 8993 8 Reverse reverse VB cord-010119-t1x9gknd 8993 9 Blood blood NN cord-010119-t1x9gknd 8993 10 grouping grouping NN cord-010119-t1x9gknd 8993 11 ( ( -LRB- cord-010119-t1x9gknd 8993 12 ABO ABO NNP cord-010119-t1x9gknd 8993 13 & & CC cord-010119-t1x9gknd 8993 14 Rh Rh NNP cord-010119-t1x9gknd 8993 15 ) ) -RRB- cord-010119-t1x9gknd 8993 16 tests test VBZ cord-010119-t1x9gknd 8993 17 , , , cord-010119-t1x9gknd 8993 18 alloantibody alloantibody NN cord-010119-t1x9gknd 8993 19 screening screening NN cord-010119-t1x9gknd 8993 20 and and CC cord-010119-t1x9gknd 8993 21 detection detection NN cord-010119-t1x9gknd 8993 22 . . . cord-010119-t1x9gknd 8994 1 Results/ Results/ . cord-010119-t1x9gknd 8995 1 Finding finding NN cord-010119-t1x9gknd 8995 2 : : : cord-010119-t1x9gknd 8996 1 Statistical statistical JJ cord-010119-t1x9gknd 8996 2 study study NN cord-010119-t1x9gknd 8996 3 is be VBZ cord-010119-t1x9gknd 8996 4 done do VBN cord-010119-t1x9gknd 8996 5 to to TO cord-010119-t1x9gknd 8996 6 determine determine VB cord-010119-t1x9gknd 8996 7 what what WP cord-010119-t1x9gknd 8996 8 is be VBZ cord-010119-t1x9gknd 8996 9 the the DT cord-010119-t1x9gknd 8996 10 effect effect NN cord-010119-t1x9gknd 8996 11 of of IN cord-010119-t1x9gknd 8996 12 splenectomy splenectomy NN cord-010119-t1x9gknd 8996 13 in in IN cord-010119-t1x9gknd 8996 14 increasing increase VBG cord-010119-t1x9gknd 8996 15 the the DT cord-010119-t1x9gknd 8996 16 rate rate NN cord-010119-t1x9gknd 8996 17 of of IN cord-010119-t1x9gknd 8996 18 red red JJ cord-010119-t1x9gknd 8996 19 cell cell NN cord-010119-t1x9gknd 8996 20 sensitization sensitization NN cord-010119-t1x9gknd 8996 21 in in IN cord-010119-t1x9gknd 8996 22 chronically chronically RB cord-010119-t1x9gknd 8996 23 transfused transfuse VBN cord-010119-t1x9gknd 8996 24 hemolytic hemolytic JJ cord-010119-t1x9gknd 8996 25 patients patient NNS cord-010119-t1x9gknd 8996 26 . . . cord-010119-t1x9gknd 8997 1 The the DT cord-010119-t1x9gknd 8997 2 study study NN cord-010119-t1x9gknd 8997 3 revealed reveal VBD cord-010119-t1x9gknd 8997 4 that that IN cord-010119-t1x9gknd 8997 5 : : : cord-010119-t1x9gknd 8997 6 32 32 CD cord-010119-t1x9gknd 8997 7 out out IN cord-010119-t1x9gknd 8997 8 of of IN cord-010119-t1x9gknd 8997 9 48 48 CD cord-010119-t1x9gknd 8997 10 ( ( -LRB- cord-010119-t1x9gknd 8997 11 67 67 CD cord-010119-t1x9gknd 8997 12 % % NN cord-010119-t1x9gknd 8997 13 ) ) -RRB- cord-010119-t1x9gknd 8997 14 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 8997 15 patients patient NNS cord-010119-t1x9gknd 8997 16 and and CC cord-010119-t1x9gknd 8997 17 16 16 CD cord-010119-t1x9gknd 8997 18 out out RB cord-010119-t1x9gknd 8997 19 of48(33 of48(33 NNP cord-010119-t1x9gknd 8997 20 % % NN cord-010119-t1x9gknd 8997 21 ) ) -RRB- cord-010119-t1x9gknd 8997 22 non non JJ cord-010119-t1x9gknd 8997 23 alloimunized alloimunized NNP cord-010119-t1x9gknd 8997 24 patients(p<0.001 patients(p<0.001 NNP cord-010119-t1x9gknd 8997 25 ) ) -RRB- cord-010119-t1x9gknd 8997 26 . . . cord-010119-t1x9gknd 8998 1 statistical statistical JJ cord-010119-t1x9gknd 8998 2 analysis analysis NN cord-010119-t1x9gknd 8998 3 show show VBP cord-010119-t1x9gknd 8998 4 that that IN cord-010119-t1x9gknd 8998 5 there there EX cord-010119-t1x9gknd 8998 6 is be VBZ cord-010119-t1x9gknd 8998 7 high high JJ cord-010119-t1x9gknd 8998 8 statistical statistical JJ cord-010119-t1x9gknd 8998 9 significant significant JJ cord-010119-t1x9gknd 8998 10 difference difference NN cord-010119-t1x9gknd 8998 11 between between IN cord-010119-t1x9gknd 8998 12 patients patient NNS cord-010119-t1x9gknd 8998 13 who who WP cord-010119-t1x9gknd 8998 14 performed perform VBD cord-010119-t1x9gknd 8998 15 splectomy splectomy NNP cord-010119-t1x9gknd 8998 16 & & CC cord-010119-t1x9gknd 8998 17 who who WP cord-010119-t1x9gknd 8998 18 did do VBD cord-010119-t1x9gknd 8998 19 not not RB cord-010119-t1x9gknd 8998 20 perform perform VB cord-010119-t1x9gknd 8998 21 splenectomy splenectomy NN cord-010119-t1x9gknd 8998 22 as as IN cord-010119-t1x9gknd 8998 23 regard regard NN cord-010119-t1x9gknd 8998 24 form form NN cord-010119-t1x9gknd 8998 25 Conclusion conclusion NN cord-010119-t1x9gknd 8998 26 : : : cord-010119-t1x9gknd 8999 1 Patients patient NNS cord-010119-t1x9gknd 8999 2 who who WP cord-010119-t1x9gknd 8999 3 had have VBD cord-010119-t1x9gknd 8999 4 splenectomy splenectomy NN cord-010119-t1x9gknd 8999 5 had have VBD cord-010119-t1x9gknd 8999 6 a a DT cord-010119-t1x9gknd 8999 7 higher high JJR cord-010119-t1x9gknd 8999 8 alloimmunization alloimmunization NN cord-010119-t1x9gknd 8999 9 rate rate NN cord-010119-t1x9gknd 8999 10 Removal removal NN cord-010119-t1x9gknd 8999 11 of of IN cord-010119-t1x9gknd 8999 12 the the DT cord-010119-t1x9gknd 8999 13 spleen spleen NN cord-010119-t1x9gknd 8999 14 is be VBZ cord-010119-t1x9gknd 8999 15 not not RB cord-010119-t1x9gknd 8999 16 recommended recommend VBN cord-010119-t1x9gknd 8999 17 in in IN cord-010119-t1x9gknd 8999 18 those those DT cord-010119-t1x9gknd 8999 19 patients patient NNS cord-010119-t1x9gknd 8999 20 who who WP cord-010119-t1x9gknd 8999 21 are be VBP cord-010119-t1x9gknd 8999 22 periodically periodically RB cord-010119-t1x9gknd 8999 23 in in IN cord-010119-t1x9gknd 8999 24 need need NN cord-010119-t1x9gknd 8999 25 of of IN cord-010119-t1x9gknd 8999 26 blood blood NN cord-010119-t1x9gknd 8999 27 and and CC cord-010119-t1x9gknd 8999 28 blood blood NN cord-010119-t1x9gknd 8999 29 components component NNS cord-010119-t1x9gknd 8999 30 . . . cord-010119-t1x9gknd 9000 1 restrictive restrictive JJ cord-010119-t1x9gknd 9000 2 transfusion transfusion NN cord-010119-t1x9gknd 9000 3 triggers trigger VBZ cord-010119-t1x9gknd 9000 4 rather rather RB cord-010119-t1x9gknd 9000 5 than than IN cord-010119-t1x9gknd 9000 6 specific specific JJ cord-010119-t1x9gknd 9000 7 evidence evidence NN cord-010119-t1x9gknd 9000 8 . . . cord-010119-t1x9gknd 9001 1 Therefore therefore RB cord-010119-t1x9gknd 9001 2 , , , cord-010119-t1x9gknd 9001 3 two two CD cord-010119-t1x9gknd 9001 4 systematic systematic JJ cord-010119-t1x9gknd 9001 5 reviews review NNS cord-010119-t1x9gknd 9001 6 of of IN cord-010119-t1x9gknd 9001 7 A A NNP cord-010119-t1x9gknd 9001 8 ) ) -RRB- cord-010119-t1x9gknd 9001 9 RBC RBC NNP cord-010119-t1x9gknd 9001 10 transfusion transfusion NN cord-010119-t1x9gknd 9001 11 guidelines guideline NNS cord-010119-t1x9gknd 9001 12 and and CC cord-010119-t1x9gknd 9001 13 review review VB cord-010119-t1x9gknd 9001 14 articles article NNS cord-010119-t1x9gknd 9001 15 to to TO cord-010119-t1x9gknd 9001 16 determine determine VB cord-010119-t1x9gknd 9001 17 if if IN cord-010119-t1x9gknd 9001 18 single single JJ cord-010119-t1x9gknd 9001 19 or or CC cord-010119-t1x9gknd 9001 20 multiple multiple JJ cord-010119-t1x9gknd 9001 21 unit unit NN cord-010119-t1x9gknd 9001 22 transfusion transfusion NN cord-010119-t1x9gknd 9001 23 strategies strategy NNS cord-010119-t1x9gknd 9001 24 are be VBP cord-010119-t1x9gknd 9001 25 recommended recommend VBN cord-010119-t1x9gknd 9001 26 and and CC cord-010119-t1x9gknd 9001 27 B b NN cord-010119-t1x9gknd 9001 28 ) ) -RRB- cord-010119-t1x9gknd 9001 29 to to TO cord-010119-t1x9gknd 9001 30 identify identify VB cord-010119-t1x9gknd 9001 31 studies study NNS cord-010119-t1x9gknd 9001 32 comparing compare VBG cord-010119-t1x9gknd 9001 33 strategies strategy NNS cord-010119-t1x9gknd 9001 34 were be VBD cord-010119-t1x9gknd 9001 35 performed perform VBN cord-010119-t1x9gknd 9001 36 . . . cord-010119-t1x9gknd 9002 1 Study Study NNP cord-010119-t1x9gknd 9002 2 Design Design NNP cord-010119-t1x9gknd 9002 3 / / SYM cord-010119-t1x9gknd 9002 4 Method method NN cord-010119-t1x9gknd 9002 5 : : : cord-010119-t1x9gknd 9003 1 Methods Methods NNPS cord-010119-t1x9gknd 9003 2 MEDLINE MEDLINE NNP cord-010119-t1x9gknd 9003 3 , , , cord-010119-t1x9gknd 9003 4 EMBASE EMBASE NNP cord-010119-t1x9gknd 9003 5 , , , cord-010119-t1x9gknd 9003 6 CINAHL CINAHL NNP cord-010119-t1x9gknd 9003 7 , , , cord-010119-t1x9gknd 9003 8 Web web NN cord-010119-t1x9gknd 9003 9 of of IN cord-010119-t1x9gknd 9003 10 Science Science NNP cord-010119-t1x9gknd 9003 11 , , , cord-010119-t1x9gknd 9003 12 National National NNP cord-010119-t1x9gknd 9003 13 Guideline Guideline NNP cord-010119-t1x9gknd 9003 14 Clearinghouse Clearinghouse NNP cord-010119-t1x9gknd 9003 15 , , , cord-010119-t1x9gknd 9003 16 and and CC cord-010119-t1x9gknd 9003 17 the the DT cord-010119-t1x9gknd 9003 18 Trip Trip NNP cord-010119-t1x9gknd 9003 19 Database Database NNP cord-010119-t1x9gknd 9003 20 were be VBD cord-010119-t1x9gknd 9003 21 searched search VBN cord-010119-t1x9gknd 9003 22 from from IN cord-010119-t1x9gknd 9003 23 inception inception NN cord-010119-t1x9gknd 9003 24 to to IN cord-010119-t1x9gknd 9003 25 June June NNP cord-010119-t1x9gknd 9003 26 2016 2016 CD cord-010119-t1x9gknd 9003 27 . . . cord-010119-t1x9gknd 9004 1 Screening screening NN cord-010119-t1x9gknd 9004 2 and and CC cord-010119-t1x9gknd 9004 3 data datum NNS cord-010119-t1x9gknd 9004 4 abstraction abstraction NN cord-010119-t1x9gknd 9004 5 were be VBD cord-010119-t1x9gknd 9004 6 done do VBN cord-010119-t1x9gknd 9004 7 independently independently RB cord-010119-t1x9gknd 9004 8 by by IN cord-010119-t1x9gknd 9004 9 two two CD cord-010119-t1x9gknd 9004 10 assessors assessor NNS cord-010119-t1x9gknd 9004 11 . . . cord-010119-t1x9gknd 9005 1 For for IN cord-010119-t1x9gknd 9005 2 review review NN cord-010119-t1x9gknd 9005 3 A a NN cord-010119-t1x9gknd 9005 4 , , , cord-010119-t1x9gknd 9005 5 the the DT cord-010119-t1x9gknd 9005 6 proportion proportion NN cord-010119-t1x9gknd 9005 7 of of IN cord-010119-t1x9gknd 9005 8 articles article NNS cord-010119-t1x9gknd 9005 9 with with IN cord-010119-t1x9gknd 9005 10 recommendations recommendation NNS cord-010119-t1x9gknd 9005 11 and and CC cord-010119-t1x9gknd 9005 12 articles article NNS cord-010119-t1x9gknd 9005 13 recommending recommend VBG cord-010119-t1x9gknd 9005 14 single single JJ cord-010119-t1x9gknd 9005 15 unit unit NN cord-010119-t1x9gknd 9005 16 strategies strategy NNS cord-010119-t1x9gknd 9005 17 were be VBD cord-010119-t1x9gknd 9005 18 assessed assess VBN cord-010119-t1x9gknd 9005 19 ; ; : cord-010119-t1x9gknd 9005 20 stratified stratify VBN cord-010119-t1x9gknd 9005 21 by by IN cord-010119-t1x9gknd 9005 22 guidelines guideline NNS cord-010119-t1x9gknd 9005 23 , , , cord-010119-t1x9gknd 9005 24 systematic systematic JJ cord-010119-t1x9gknd 9005 25 reviews review NNS cord-010119-t1x9gknd 9005 26 , , , cord-010119-t1x9gknd 9005 27 and and CC cord-010119-t1x9gknd 9005 28 other other JJ cord-010119-t1x9gknd 9005 29 review review NN cord-010119-t1x9gknd 9005 30 articles article NNS cord-010119-t1x9gknd 9005 31 . . . cord-010119-t1x9gknd 9006 1 For for IN cord-010119-t1x9gknd 9006 2 review review NN cord-010119-t1x9gknd 9006 3 B b NN cord-010119-t1x9gknd 9006 4 , , , cord-010119-t1x9gknd 9006 5 the the DT cord-010119-t1x9gknd 9006 6 primary primary JJ cord-010119-t1x9gknd 9006 7 outcome outcome NN cord-010119-t1x9gknd 9006 8 was be VBD cord-010119-t1x9gknd 9006 9 RBC RBC NNP cord-010119-t1x9gknd 9006 10 utilization utilization NN cord-010119-t1x9gknd 9006 11 . . . cord-010119-t1x9gknd 9007 1 Secondary secondary JJ cord-010119-t1x9gknd 9007 2 outcomes outcome NNS cord-010119-t1x9gknd 9007 3 included include VBD cord-010119-t1x9gknd 9007 4 proportion proportion NN cord-010119-t1x9gknd 9007 5 of of IN cord-010119-t1x9gknd 9007 6 units unit NNS cord-010119-t1x9gknd 9007 7 transfused transfuse VBN cord-010119-t1x9gknd 9007 8 using use VBG cord-010119-t1x9gknd 9007 9 a a DT cord-010119-t1x9gknd 9007 10 single single JJ cord-010119-t1x9gknd 9007 11 unit unit NN cord-010119-t1x9gknd 9007 12 strategy strategy NN cord-010119-t1x9gknd 9007 13 , , , cord-010119-t1x9gknd 9007 14 length length NN cord-010119-t1x9gknd 9007 15 of of IN cord-010119-t1x9gknd 9007 16 stay stay NN cord-010119-t1x9gknd 9007 17 , , , cord-010119-t1x9gknd 9007 18 and and CC cord-010119-t1x9gknd 9007 19 mortality mortality NN cord-010119-t1x9gknd 9007 20 . . . cord-010119-t1x9gknd 9008 1 Meta Meta NNP cord-010119-t1x9gknd 9008 2 - - HYPH cord-010119-t1x9gknd 9008 3 analysis analysis NN cord-010119-t1x9gknd 9008 4 was be VBD cord-010119-t1x9gknd 9008 5 done do VBN cord-010119-t1x9gknd 9008 6 using use VBG cord-010119-t1x9gknd 9008 7 the the DT cord-010119-t1x9gknd 9008 8 Mantel Mantel NNP cord-010119-t1x9gknd 9008 9 Haenszel Haenszel NNP cord-010119-t1x9gknd 9008 10 random random JJ cord-010119-t1x9gknd 9008 11 effects effect NNS cord-010119-t1x9gknd 9008 12 model model NN cord-010119-t1x9gknd 9008 13 . . . cord-010119-t1x9gknd 9009 1 Results result NNS cord-010119-t1x9gknd 9010 1 /Finding /finde VBG cord-010119-t1x9gknd 9010 2 : : : cord-010119-t1x9gknd 9011 1 Review Review NNP cord-010119-t1x9gknd 9011 2 A A NNP cord-010119-t1x9gknd 9011 3 identified identify VBD cord-010119-t1x9gknd 9011 4 136 136 CD cord-010119-t1x9gknd 9011 5 articles article NNS cord-010119-t1x9gknd 9011 6 for for IN cord-010119-t1x9gknd 9011 7 data datum NNS cord-010119-t1x9gknd 9011 8 abstraction abstraction NN cord-010119-t1x9gknd 9011 9 , , , cord-010119-t1x9gknd 9011 10 where where WRB cord-010119-t1x9gknd 9011 11 48 48 CD cord-010119-t1x9gknd 9011 12 articles article NNS cord-010119-t1x9gknd 9011 13 were be VBD cord-010119-t1x9gknd 9011 14 transfusion transfusion NN cord-010119-t1x9gknd 9011 15 guidelines guideline NNS cord-010119-t1x9gknd 9011 16 . . . cord-010119-t1x9gknd 9012 1 There there EX cord-010119-t1x9gknd 9012 2 were be VBD cord-010119-t1x9gknd 9012 3 12 12 CD cord-010119-t1x9gknd 9012 4 guidelines guideline NNS cord-010119-t1x9gknd 9012 5 ( ( -LRB- cord-010119-t1x9gknd 9012 6 25 25 CD cord-010119-t1x9gknd 9012 7 % % NN cord-010119-t1x9gknd 9012 8 ) ) -RRB- cord-010119-t1x9gknd 9012 9 that that WDT cord-010119-t1x9gknd 9012 10 made make VBD cord-010119-t1x9gknd 9012 11 a a DT cord-010119-t1x9gknd 9012 12 recommendation recommendation NN cord-010119-t1x9gknd 9012 13 , , , cord-010119-t1x9gknd 9012 14 11 11 CD cord-010119-t1x9gknd 9012 15 for for IN cord-010119-t1x9gknd 9012 16 a a DT cord-010119-t1x9gknd 9012 17 single single JJ cord-010119-t1x9gknd 9012 18 unit unit NN cord-010119-t1x9gknd 9012 19 and and CC cord-010119-t1x9gknd 9012 20 1 1 CD cord-010119-t1x9gknd 9012 21 for for IN cord-010119-t1x9gknd 9012 22 multiple multiple JJ cord-010119-t1x9gknd 9012 23 unit unit NN cord-010119-t1x9gknd 9012 24 transfusion transfusion NN cord-010119-t1x9gknd 9012 25 strategy strategy NN cord-010119-t1x9gknd 9012 26 ( ( -LRB- cord-010119-t1x9gknd 9012 27 Table table NN cord-010119-t1x9gknd 9012 28 1 1 CD cord-010119-t1x9gknd 9012 29 ) ) -RRB- cord-010119-t1x9gknd 9012 30 . . . cord-010119-t1x9gknd 9013 1 Review Review NNP cord-010119-t1x9gknd 9013 2 B B NNP cord-010119-t1x9gknd 9013 3 identified identify VBD cord-010119-t1x9gknd 9013 4 3 3 CD cord-010119-t1x9gknd 9013 5 retrospective retrospective JJ cord-010119-t1x9gknd 9013 6 cohort cohort NN cord-010119-t1x9gknd 9013 7 studies study NNS cord-010119-t1x9gknd 9013 8 that that WDT cord-010119-t1x9gknd 9013 9 were be VBD cord-010119-t1x9gknd 9013 10 eligible eligible JJ cord-010119-t1x9gknd 9013 11 and and CC cord-010119-t1x9gknd 9013 12 data datum NNS cord-010119-t1x9gknd 9013 13 abstraction abstraction NN cord-010119-t1x9gknd 9013 14 was be VBD cord-010119-t1x9gknd 9013 15 performed perform VBN cord-010119-t1x9gknd 9013 16 . . . cord-010119-t1x9gknd 9014 1 All all DT cord-010119-t1x9gknd 9014 2 utilized utilize VBD cord-010119-t1x9gknd 9014 3 a a DT cord-010119-t1x9gknd 9014 4 policy policy NN cord-010119-t1x9gknd 9014 5 encouraging encourage VBG cord-010119-t1x9gknd 9014 6 single single JJ cord-010119-t1x9gknd 9014 7 unit unit NN cord-010119-t1x9gknd 9014 8 transfusion transfusion NN cord-010119-t1x9gknd 9014 9 strategies strategy NNS cord-010119-t1x9gknd 9014 10 and and CC cord-010119-t1x9gknd 9014 11 compared compare VBD cord-010119-t1x9gknd 9014 12 a a DT cord-010119-t1x9gknd 9014 13 pre pre JJ cord-010119-t1x9gknd 9014 14 - - JJ cord-010119-t1x9gknd 9014 15 implementation implementation JJ cord-010119-t1x9gknd 9014 16 period period NN cord-010119-t1x9gknd 9014 17 to to IN cord-010119-t1x9gknd 9014 18 a a DT cord-010119-t1x9gknd 9014 19 post post JJ cord-010119-t1x9gknd 9014 20 - - JJ cord-010119-t1x9gknd 9014 21 implementation implementation JJ cord-010119-t1x9gknd 9014 22 period period NN cord-010119-t1x9gknd 9014 23 . . . cord-010119-t1x9gknd 9015 1 Meta Meta NNP cord-010119-t1x9gknd 9015 2 - - HYPH cord-010119-t1x9gknd 9015 3 analysis analysis NN cord-010119-t1x9gknd 9015 4 could could MD cord-010119-t1x9gknd 9015 5 only only RB cord-010119-t1x9gknd 9015 6 be be VB cord-010119-t1x9gknd 9015 7 performed perform VBN cord-010119-t1x9gknd 9015 8 on on IN cord-010119-t1x9gknd 9015 9 the the DT cord-010119-t1x9gknd 9015 10 secondary secondary JJ cord-010119-t1x9gknd 9015 11 outcome outcome NN cord-010119-t1x9gknd 9015 12 of of IN cord-010119-t1x9gknd 9015 13 the the DT cord-010119-t1x9gknd 9015 14 proportion proportion NN cord-010119-t1x9gknd 9015 15 of of IN cord-010119-t1x9gknd 9015 16 units unit NNS cord-010119-t1x9gknd 9015 17 transfused transfuse VBN cord-010119-t1x9gknd 9015 18 using use VBG cord-010119-t1x9gknd 9015 19 a a DT cord-010119-t1x9gknd 9015 20 single single JJ cord-010119-t1x9gknd 9015 21 unit unit NN cord-010119-t1x9gknd 9015 22 strategy strategy NN cord-010119-t1x9gknd 9015 23 , , , cord-010119-t1x9gknd 9015 24 which which WDT cord-010119-t1x9gknd 9015 25 was be VBD cord-010119-t1x9gknd 9015 26 higher high JJR cord-010119-t1x9gknd 9015 27 after after IN cord-010119-t1x9gknd 9015 28 the the DT cord-010119-t1x9gknd 9015 29 policy policy NN cord-010119-t1x9gknd 9015 30 intervention intervention NN cord-010119-t1x9gknd 9015 31 ( ( -LRB- cord-010119-t1x9gknd 9015 32 OR or CC cord-010119-t1x9gknd 9015 33 9.4 9.4 CD cord-010119-t1x9gknd 9015 34 , , , cord-010119-t1x9gknd 9015 35 95 95 CD cord-010119-t1x9gknd 9015 36 % % NN cord-010119-t1x9gknd 9015 37 CI CI NNP cord-010119-t1x9gknd 9015 38 5.02 5.02 CD cord-010119-t1x9gknd 9015 39 - - HYPH cord-010119-t1x9gknd 9015 40 17.60 17.60 CD cord-010119-t1x9gknd 9015 41 ) ) -RRB- cord-010119-t1x9gknd 9015 42 , , , cord-010119-t1x9gknd 9015 43 although although IN cord-010119-t1x9gknd 9015 44 heterogeneity heterogeneity NN cord-010119-t1x9gknd 9015 45 was be VBD cord-010119-t1x9gknd 9015 46 high high JJ cord-010119-t1x9gknd 9015 47 ( ( -LRB- cord-010119-t1x9gknd 9015 48 I i NN cord-010119-t1x9gknd 9015 49 2 2 CD cord-010119-t1x9gknd 9015 50 597 597 CD cord-010119-t1x9gknd 9015 51 % % NN cord-010119-t1x9gknd 9015 52 ) ) -RRB- cord-010119-t1x9gknd 9015 53 . . . cord-010119-t1x9gknd 9016 1 Conclusion conclusion NN cord-010119-t1x9gknd 9016 2 : : : cord-010119-t1x9gknd 9017 1 Our -PRON- PRP$ cord-010119-t1x9gknd 9017 2 systematic systematic JJ cord-010119-t1x9gknd 9017 3 reviews review NNS cord-010119-t1x9gknd 9017 4 demonstrated demonstrate VBD cord-010119-t1x9gknd 9017 5 a a DT cord-010119-t1x9gknd 9017 6 lack lack NN cord-010119-t1x9gknd 9017 7 of of IN cord-010119-t1x9gknd 9017 8 recommendations recommendation NNS cord-010119-t1x9gknd 9017 9 amongst amongst IN cord-010119-t1x9gknd 9017 10 guidelines guideline NNS cord-010119-t1x9gknd 9017 11 pertaining pertain VBG cord-010119-t1x9gknd 9017 12 to to IN cord-010119-t1x9gknd 9017 13 transfusing transfuse VBG cord-010119-t1x9gknd 9017 14 single single JJ cord-010119-t1x9gknd 9017 15 units unit NNS cord-010119-t1x9gknd 9017 16 of of IN cord-010119-t1x9gknd 9017 17 RBCs rbc NNS cord-010119-t1x9gknd 9017 18 and and CC cord-010119-t1x9gknd 9017 19 only only RB cord-010119-t1x9gknd 9017 20 a a DT cord-010119-t1x9gknd 9017 21 few few JJ cord-010119-t1x9gknd 9017 22 retrospective retrospective JJ cord-010119-t1x9gknd 9017 23 cohort cohort NN cord-010119-t1x9gknd 9017 24 studies study NNS cord-010119-t1x9gknd 9017 25 to to TO cord-010119-t1x9gknd 9017 26 support support VB cord-010119-t1x9gknd 9017 27 benefits benefit NNS cord-010119-t1x9gknd 9017 28 of of IN cord-010119-t1x9gknd 9017 29 the the DT cord-010119-t1x9gknd 9017 30 use use NN cord-010119-t1x9gknd 9017 31 of of IN cord-010119-t1x9gknd 9017 32 single single JJ cord-010119-t1x9gknd 9017 33 unit unit NN cord-010119-t1x9gknd 9017 34 transfusion transfusion NN cord-010119-t1x9gknd 9017 35 strategies strategy NNS cord-010119-t1x9gknd 9017 36 . . . cord-010119-t1x9gknd 9018 1 Additional additional JJ cord-010119-t1x9gknd 9018 2 high high JJ cord-010119-t1x9gknd 9018 3 quality quality NN cord-010119-t1x9gknd 9018 4 studies study NNS cord-010119-t1x9gknd 9018 5 are be VBP cord-010119-t1x9gknd 9018 6 needed need VBN cord-010119-t1x9gknd 9018 7 to to TO cord-010119-t1x9gknd 9018 8 identify identify VB cord-010119-t1x9gknd 9018 9 the the DT cord-010119-t1x9gknd 9018 10 benefits benefit NNS cord-010119-t1x9gknd 9018 11 of of IN cord-010119-t1x9gknd 9018 12 a a DT cord-010119-t1x9gknd 9018 13 single single JJ cord-010119-t1x9gknd 9018 14 unit unit NN cord-010119-t1x9gknd 9018 15 transfusion transfusion NN cord-010119-t1x9gknd 9018 16 strategy strategy NN cord-010119-t1x9gknd 9018 17 and and CC cord-010119-t1x9gknd 9018 18 when when WRB cord-010119-t1x9gknd 9018 19 it -PRON- PRP cord-010119-t1x9gknd 9018 20 should should MD cord-010119-t1x9gknd 9018 21 be be VB cord-010119-t1x9gknd 9018 22 used use VBN cord-010119-t1x9gknd 9018 23 . . . cord-010119-t1x9gknd 9019 1 Guidelines guideline NNS cord-010119-t1x9gknd 9019 2 groups group NNS cord-010119-t1x9gknd 9019 3 should should MD cord-010119-t1x9gknd 9019 4 review review VB cord-010119-t1x9gknd 9019 5 research research NN cord-010119-t1x9gknd 9019 6 in in IN cord-010119-t1x9gknd 9019 7 this this DT cord-010119-t1x9gknd 9019 8 area area NN cord-010119-t1x9gknd 9019 9 to to TO cord-010119-t1x9gknd 9019 10 determine determine VB cord-010119-t1x9gknd 9019 11 if if IN cord-010119-t1x9gknd 9019 12 a a DT cord-010119-t1x9gknd 9019 13 recommendation recommendation NN cord-010119-t1x9gknd 9019 14 can can MD cord-010119-t1x9gknd 9019 15 be be VB cord-010119-t1x9gknd 9019 16 made make VBN cord-010119-t1x9gknd 9019 17 . . . cord-010119-t1x9gknd 9020 1 Background Background NNP cord-010119-t1x9gknd 9020 2 / / SYM cord-010119-t1x9gknd 9020 3 Case Case NNP cord-010119-t1x9gknd 9020 4 Studies Studies NNPS cord-010119-t1x9gknd 9020 5 : : : cord-010119-t1x9gknd 9021 1 Platelets platelet NNS cord-010119-t1x9gknd 9021 2 made make VBN cord-010119-t1x9gknd 9021 3 with with IN cord-010119-t1x9gknd 9021 4 platelet platelet NN cord-010119-t1x9gknd 9021 5 additive additive NN cord-010119-t1x9gknd 9021 6 solution solution NN cord-010119-t1x9gknd 9021 7 C C NNP cord-010119-t1x9gknd 9021 8 ( ( -LRB- cord-010119-t1x9gknd 9021 9 PAS pas NN cord-010119-t1x9gknd 9021 10 C C NNP cord-010119-t1x9gknd 9021 11 ) ) -RRB- cord-010119-t1x9gknd 9021 12 and and CC cord-010119-t1x9gknd 9021 13 treated treat VBN cord-010119-t1x9gknd 9021 14 for for IN cord-010119-t1x9gknd 9021 15 Pathogen Pathogen NNP cord-010119-t1x9gknd 9021 16 Reduction Reduction NNP cord-010119-t1x9gknd 9021 17 ( ( -LRB- cord-010119-t1x9gknd 9021 18 PR PR NNP cord-010119-t1x9gknd 9021 19 ) ) -RRB- cord-010119-t1x9gknd 9021 20 have have VBP cord-010119-t1x9gknd 9021 21 been be VBN cord-010119-t1x9gknd 9021 22 shown show VBN cord-010119-t1x9gknd 9021 23 to to TO cord-010119-t1x9gknd 9021 24 have have VB cord-010119-t1x9gknd 9021 25 decreased decrease VBN cord-010119-t1x9gknd 9021 26 post post JJ cord-010119-t1x9gknd 9021 27 transfusion transfusion NN cord-010119-t1x9gknd 9021 28 platelet platelet NN cord-010119-t1x9gknd 9021 29 counts count VBZ cord-010119-t1x9gknd 9021 30 from from IN cord-010119-t1x9gknd 9021 31 platelets platelet NNS cord-010119-t1x9gknd 9021 32 stored store VBN cord-010119-t1x9gknd 9021 33 in in IN cord-010119-t1x9gknd 9021 34 all all DT cord-010119-t1x9gknd 9021 35 plasma plasma NN cord-010119-t1x9gknd 9021 36 . . . cord-010119-t1x9gknd 9022 1 With with IN cord-010119-t1x9gknd 9022 2 the the DT cord-010119-t1x9gknd 9022 3 advent advent NN cord-010119-t1x9gknd 9022 4 of of IN cord-010119-t1x9gknd 9022 5 multiple multiple JJ cord-010119-t1x9gknd 9022 6 types type NNS cord-010119-t1x9gknd 9022 7 of of IN cord-010119-t1x9gknd 9022 8 platelets platelet NNS cord-010119-t1x9gknd 9022 9 , , , cord-010119-t1x9gknd 9022 10 we -PRON- PRP cord-010119-t1x9gknd 9022 11 are be VBP cord-010119-t1x9gknd 9022 12 evaluating evaluate VBG cord-010119-t1x9gknd 9022 13 whether whether IN cord-010119-t1x9gknd 9022 14 a a DT cord-010119-t1x9gknd 9022 15 mixed mixed JJ cord-010119-t1x9gknd 9022 16 platelet platelet NN cord-010119-t1x9gknd 9022 17 inventory inventory NN cord-010119-t1x9gknd 9022 18 has have VBZ cord-010119-t1x9gknd 9022 19 had have VBN cord-010119-t1x9gknd 9022 20 an an DT cord-010119-t1x9gknd 9022 21 effect effect NN cord-010119-t1x9gknd 9022 22 on on IN cord-010119-t1x9gknd 9022 23 component component NN cord-010119-t1x9gknd 9022 24 use use NN cord-010119-t1x9gknd 9022 25 . . . cord-010119-t1x9gknd 9023 1 The the DT cord-010119-t1x9gknd 9023 2 literature literature NN cord-010119-t1x9gknd 9023 3 from from IN cord-010119-t1x9gknd 9023 4 Europe Europe NNP cord-010119-t1x9gknd 9023 5 has have VBZ cord-010119-t1x9gknd 9023 6 shown show VBN cord-010119-t1x9gknd 9023 7 that that IN cord-010119-t1x9gknd 9023 8 platelet platelet NN cord-010119-t1x9gknd 9023 9 and and CC cord-010119-t1x9gknd 9023 10 red red JJ cord-010119-t1x9gknd 9023 11 cell cell NN cord-010119-t1x9gknd 9023 12 use use NN cord-010119-t1x9gknd 9023 13 does do VBZ cord-010119-t1x9gknd 9023 14 not not RB cord-010119-t1x9gknd 9023 15 increase increase VB cord-010119-t1x9gknd 9023 16 when when WRB cord-010119-t1x9gknd 9023 17 PR PR NNP cord-010119-t1x9gknd 9023 18 and and CC cord-010119-t1x9gknd 9023 19 PAS pas NN cord-010119-t1x9gknd 9023 20 products product NNS cord-010119-t1x9gknd 9023 21 are be VBP cord-010119-t1x9gknd 9023 22 used use VBN cord-010119-t1x9gknd 9023 23 . . . cord-010119-t1x9gknd 9024 1 Evaluation Evaluation NNP cord-010119-t1x9gknd 9024 2 of of IN cord-010119-t1x9gknd 9024 3 RBC RBC NNP cord-010119-t1x9gknd 9024 4 use use NN cord-010119-t1x9gknd 9024 5 at at IN cord-010119-t1x9gknd 9024 6 our -PRON- PRP$ cord-010119-t1x9gknd 9024 7 institution institution NN cord-010119-t1x9gknd 9024 8 has have VBZ cord-010119-t1x9gknd 9024 9 shown show VBN cord-010119-t1x9gknd 9024 10 no no DT cord-010119-t1x9gknd 9024 11 change change NN cord-010119-t1x9gknd 9024 12 in in IN cord-010119-t1x9gknd 9024 13 the the DT cord-010119-t1x9gknd 9024 14 number number NN cord-010119-t1x9gknd 9024 15 of of IN cord-010119-t1x9gknd 9024 16 products product NNS cord-010119-t1x9gknd 9024 17 transfused transfuse VBN cord-010119-t1x9gknd 9024 18 per per IN cord-010119-t1x9gknd 9024 19 patient patient NN cord-010119-t1x9gknd 9024 20 per per IN cord-010119-t1x9gknd 9024 21 month month NN cord-010119-t1x9gknd 9024 22 . . . cord-010119-t1x9gknd 9025 1 We -PRON- PRP cord-010119-t1x9gknd 9025 2 are be VBP cord-010119-t1x9gknd 9025 3 evaluating evaluate VBG cord-010119-t1x9gknd 9025 4 whether whether IN cord-010119-t1x9gknd 9025 5 the the DT cord-010119-t1x9gknd 9025 6 mixed mixed JJ cord-010119-t1x9gknd 9025 7 inventory inventory NN cord-010119-t1x9gknd 9025 8 has have VBZ cord-010119-t1x9gknd 9025 9 led lead VBN cord-010119-t1x9gknd 9025 10 to to IN cord-010119-t1x9gknd 9025 11 more more JJR cord-010119-t1x9gknd 9025 12 platelet platelet NN cord-010119-t1x9gknd 9025 13 transfusions transfusion NNS cord-010119-t1x9gknd 9025 14 . . . cord-010119-t1x9gknd 9026 1 Study Study NNP cord-010119-t1x9gknd 9026 2 Design Design NNP cord-010119-t1x9gknd 9026 3 / / SYM cord-010119-t1x9gknd 9026 4 Method method NN cord-010119-t1x9gknd 9026 5 : : : cord-010119-t1x9gknd 9027 1 We -PRON- PRP cord-010119-t1x9gknd 9027 2 looked look VBD cord-010119-t1x9gknd 9027 3 at at IN cord-010119-t1x9gknd 9027 4 occasions occasion NNS cord-010119-t1x9gknd 9027 5 when when WRB cord-010119-t1x9gknd 9027 6 patients patient NNS cord-010119-t1x9gknd 9027 7 received receive VBD cord-010119-t1x9gknd 9027 8 all all DT cord-010119-t1x9gknd 9027 9 of of IN cord-010119-t1x9gknd 9027 10 their -PRON- PRP$ cord-010119-t1x9gknd 9027 11 platelet platelet NN cord-010119-t1x9gknd 9027 12 transfusions transfusion NNS cord-010119-t1x9gknd 9027 13 on on IN cord-010119-t1x9gknd 9027 14 a a DT cord-010119-t1x9gknd 9027 15 single single JJ cord-010119-t1x9gknd 9027 16 day day NN cord-010119-t1x9gknd 9027 17 . . . cord-010119-t1x9gknd 9028 1 By by IN cord-010119-t1x9gknd 9028 2 doing do VBG cord-010119-t1x9gknd 9028 3 this this DT cord-010119-t1x9gknd 9028 4 we -PRON- PRP cord-010119-t1x9gknd 9028 5 were be VBD cord-010119-t1x9gknd 9028 6 able able JJ cord-010119-t1x9gknd 9028 7 to to TO cord-010119-t1x9gknd 9028 8 exclude exclude VB cord-010119-t1x9gknd 9028 9 refractory refractory JJ cord-010119-t1x9gknd 9028 10 patients patient NNS cord-010119-t1x9gknd 9028 11 from from IN cord-010119-t1x9gknd 9028 12 the the DT cord-010119-t1x9gknd 9028 13 analysis analysis NN cord-010119-t1x9gknd 9028 14 . . . cord-010119-t1x9gknd 9029 1 The the DT cord-010119-t1x9gknd 9029 2 information information NN cord-010119-t1x9gknd 9029 3 obtained obtain VBN cord-010119-t1x9gknd 9029 4 from from IN cord-010119-t1x9gknd 9029 5 routine routine JJ cord-010119-t1x9gknd 9029 6 Quality Quality NNP cord-010119-t1x9gknd 9029 7 Management Management NNP cord-010119-t1x9gknd 9029 8 audits audits NN cord-010119-t1x9gknd 9029 9 of of IN cord-010119-t1x9gknd 9029 10 transfusions transfusion NNS cord-010119-t1x9gknd 9029 11 between between IN cord-010119-t1x9gknd 9029 12 December December NNP cord-010119-t1x9gknd 9029 13 2016 2016 CD cord-010119-t1x9gknd 9029 14 and and CC cord-010119-t1x9gknd 9029 15 February February NNP cord-010119-t1x9gknd 9029 16 2017 2017 CD cord-010119-t1x9gknd 9029 17 was be VBD cord-010119-t1x9gknd 9029 18 used use VBN cord-010119-t1x9gknd 9029 19 for for IN cord-010119-t1x9gknd 9029 20 this this DT cord-010119-t1x9gknd 9029 21 analysis analysis NN cord-010119-t1x9gknd 9029 22 . . . cord-010119-t1x9gknd 9030 1 The the DT cord-010119-t1x9gknd 9030 2 information information NN cord-010119-t1x9gknd 9030 3 included include VBD cord-010119-t1x9gknd 9030 4 the the DT cord-010119-t1x9gknd 9030 5 ordering ordering NN cord-010119-t1x9gknd 9030 6 service service NN cord-010119-t1x9gknd 9030 7 , , , cord-010119-t1x9gknd 9030 8 product product NN cord-010119-t1x9gknd 9030 9 release release NN cord-010119-t1x9gknd 9030 10 time time NN cord-010119-t1x9gknd 9030 11 , , , cord-010119-t1x9gknd 9030 12 product product NN cord-010119-t1x9gknd 9030 13 code code NN cord-010119-t1x9gknd 9030 14 , , , cord-010119-t1x9gknd 9030 15 pre pre VB cord-010119-t1x9gknd 9030 16 and and CC cord-010119-t1x9gknd 9030 17 post post JJ cord-010119-t1x9gknd 9030 18 counts count NNS cord-010119-t1x9gknd 9030 19 . . . cord-010119-t1x9gknd 9031 1 Statistical statistical JJ cord-010119-t1x9gknd 9031 2 analysis analysis NN cord-010119-t1x9gknd 9031 3 was be VBD cord-010119-t1x9gknd 9031 4 performed perform VBN cord-010119-t1x9gknd 9031 5 using use VBG cord-010119-t1x9gknd 9031 6 Minitab Minitab NNP cord-010119-t1x9gknd 9031 7 . . . cord-010119-t1x9gknd 9032 1 Results/ Results/ . cord-010119-t1x9gknd 9033 1 Finding finding NN cord-010119-t1x9gknd 9033 2 : : : cord-010119-t1x9gknd 9034 1 During during IN cord-010119-t1x9gknd 9034 2 the the DT cord-010119-t1x9gknd 9034 3 3 3 CD cord-010119-t1x9gknd 9034 4 months month NNS cord-010119-t1x9gknd 9034 5 , , , cord-010119-t1x9gknd 9034 6 1723 1723 CD cord-010119-t1x9gknd 9034 7 units unit NNS cord-010119-t1x9gknd 9034 8 of of IN cord-010119-t1x9gknd 9034 9 platelets platelet NNS cord-010119-t1x9gknd 9034 10 were be VBD cord-010119-t1x9gknd 9034 11 transfused transfuse VBN cord-010119-t1x9gknd 9034 12 to to IN cord-010119-t1x9gknd 9034 13 238 238 CD cord-010119-t1x9gknd 9034 14 recipients recipient NNS cord-010119-t1x9gknd 9034 15 . . . cord-010119-t1x9gknd 9035 1 Over over IN cord-010119-t1x9gknd 9035 2 the the DT cord-010119-t1x9gknd 9035 3 3 3 CD cord-010119-t1x9gknd 9035 4 months month NNS cord-010119-t1x9gknd 9035 5 , , , cord-010119-t1x9gknd 9035 6 a a DT cord-010119-t1x9gknd 9035 7 median median NN cord-010119-t1x9gknd 9035 8 of of IN cord-010119-t1x9gknd 9035 9 4 4 CD cord-010119-t1x9gknd 9035 10 units unit NNS cord-010119-t1x9gknd 9035 11 was be VBD cord-010119-t1x9gknd 9035 12 given give VBN cord-010119-t1x9gknd 9035 13 to to IN cord-010119-t1x9gknd 9035 14 each each DT cord-010119-t1x9gknd 9035 15 patient patient NN cord-010119-t1x9gknd 9035 16 with with IN cord-010119-t1x9gknd 9035 17 a a DT cord-010119-t1x9gknd 9035 18 range range NN cord-010119-t1x9gknd 9035 19 of of IN cord-010119-t1x9gknd 9035 20 1 1 CD cord-010119-t1x9gknd 9035 21 to to IN cord-010119-t1x9gknd 9035 22 69 69 CD cord-010119-t1x9gknd 9035 23 . . . cord-010119-t1x9gknd 9036 1 The the DT cord-010119-t1x9gknd 9036 2 overall overall JJ cord-010119-t1x9gknd 9036 3 distribution distribution NN cord-010119-t1x9gknd 9036 4 of of IN cord-010119-t1x9gknd 9036 5 products product NNS cord-010119-t1x9gknd 9036 6 used use VBN cord-010119-t1x9gknd 9036 7 was be VBD cord-010119-t1x9gknd 9036 8 58 58 CD cord-010119-t1x9gknd 9036 9 % % NN cord-010119-t1x9gknd 9036 10 plasma plasma NN cord-010119-t1x9gknd 9036 11 , , , cord-010119-t1x9gknd 9036 12 24 24 CD cord-010119-t1x9gknd 9036 13 % % NN cord-010119-t1x9gknd 9036 14 PR pr NN cord-010119-t1x9gknd 9036 15 , , , cord-010119-t1x9gknd 9036 16 7 7 CD cord-010119-t1x9gknd 9036 17 % % NN cord-010119-t1x9gknd 9036 18 PAS pas NN cord-010119-t1x9gknd 9036 19 F f NN cord-010119-t1x9gknd 9036 20 and and CC cord-010119-t1x9gknd 9037 1 11 11 CD cord-010119-t1x9gknd 9037 2 % % NN cord-010119-t1x9gknd 9037 3 PAS pas NN cord-010119-t1x9gknd 9037 4 C. C. NNP cord-010119-t1x9gknd 9037 5 Thirty Thirty NNP cord-010119-t1x9gknd 9037 6 percent percent NN cord-010119-t1x9gknd 9037 7 of of IN cord-010119-t1x9gknd 9037 8 patients patient NNS cord-010119-t1x9gknd 9037 9 ( ( -LRB- cord-010119-t1x9gknd 9037 10 N572 N572 NNP cord-010119-t1x9gknd 9037 11 ) ) -RRB- cord-010119-t1x9gknd 9037 12 received receive VBD cord-010119-t1x9gknd 9037 13 all all DT cord-010119-t1x9gknd 9037 14 of of IN cord-010119-t1x9gknd 9037 15 their -PRON- PRP$ cord-010119-t1x9gknd 9037 16 products product NNS cord-010119-t1x9gknd 9037 17 on on IN cord-010119-t1x9gknd 9037 18 a a DT cord-010119-t1x9gknd 9037 19 single single JJ cord-010119-t1x9gknd 9037 20 day day NN cord-010119-t1x9gknd 9037 21 . . . cord-010119-t1x9gknd 9038 1 Single single JJ cord-010119-t1x9gknd 9038 2 units unit NNS cord-010119-t1x9gknd 9038 3 were be VBD cord-010119-t1x9gknd 9038 4 given give VBN cord-010119-t1x9gknd 9038 5 to to IN cord-010119-t1x9gknd 9038 6 54 54 CD cord-010119-t1x9gknd 9038 7 patients patient NNS cord-010119-t1x9gknd 9038 8 while while IN cord-010119-t1x9gknd 9038 9 14 14 CD cord-010119-t1x9gknd 9038 10 , , , cord-010119-t1x9gknd 9038 11 3 3 CD cord-010119-t1x9gknd 9038 12 and and CC cord-010119-t1x9gknd 9038 13 1 1 CD cord-010119-t1x9gknd 9038 14 received receive VBD cord-010119-t1x9gknd 9038 15 2 2 CD cord-010119-t1x9gknd 9038 16 , , , cord-010119-t1x9gknd 9038 17 3 3 CD cord-010119-t1x9gknd 9038 18 , , , cord-010119-t1x9gknd 9038 19 and and CC cord-010119-t1x9gknd 9038 20 4 4 CD cord-010119-t1x9gknd 9038 21 units unit NNS cord-010119-t1x9gknd 9038 22 respectively respectively RB cord-010119-t1x9gknd 9038 23 . . . cord-010119-t1x9gknd 9039 1 The the DT cord-010119-t1x9gknd 9039 2 distribution distribution NN cord-010119-t1x9gknd 9039 3 by by IN cord-010119-t1x9gknd 9039 4 product product NN cord-010119-t1x9gknd 9039 5 type type NN cord-010119-t1x9gknd 9039 6 was be VBD cord-010119-t1x9gknd 9039 7 56 56 CD cord-010119-t1x9gknd 9039 8 % % NN cord-010119-t1x9gknd 9039 9 plasma plasma NN cord-010119-t1x9gknd 9039 10 , , , cord-010119-t1x9gknd 9039 11 25 25 CD cord-010119-t1x9gknd 9039 12 % % NN cord-010119-t1x9gknd 9039 13 PR pr NN cord-010119-t1x9gknd 9039 14 , , , cord-010119-t1x9gknd 9039 15 13 13 CD cord-010119-t1x9gknd 9039 16 % % NN cord-010119-t1x9gknd 9039 17 PAS pas NN cord-010119-t1x9gknd 9039 18 C c NN cord-010119-t1x9gknd 9039 19 and and CC cord-010119-t1x9gknd 9039 20 4 4 CD cord-010119-t1x9gknd 9039 21 % % NN cord-010119-t1x9gknd 9039 22 PAS pas NN cord-010119-t1x9gknd 9039 23 F. f. NN cord-010119-t1x9gknd 9040 1 This this DT cord-010119-t1x9gknd 9040 2 same same JJ cord-010119-t1x9gknd 9040 3 percentage percentage NN cord-010119-t1x9gknd 9040 4 was be VBD cord-010119-t1x9gknd 9040 5 present present JJ cord-010119-t1x9gknd 9040 6 for for IN cord-010119-t1x9gknd 9040 7 single single JJ cord-010119-t1x9gknd 9040 8 and and CC cord-010119-t1x9gknd 9040 9 multiple multiple JJ cord-010119-t1x9gknd 9040 10 products product NNS cord-010119-t1x9gknd 9040 11 and and CC cord-010119-t1x9gknd 9040 12 was be VBD cord-010119-t1x9gknd 9040 13 not not RB cord-010119-t1x9gknd 9040 14 statistically statistically RB cord-010119-t1x9gknd 9040 15 significantly significantly RB cord-010119-t1x9gknd 9040 16 different different JJ cord-010119-t1x9gknd 9040 17 from from IN cord-010119-t1x9gknd 9040 18 the the DT cord-010119-t1x9gknd 9040 19 overall overall JJ cord-010119-t1x9gknd 9040 20 distribution distribution NN cord-010119-t1x9gknd 9040 21 of of IN cord-010119-t1x9gknd 9040 22 the the DT cord-010119-t1x9gknd 9040 23 products product NNS cord-010119-t1x9gknd 9040 24 given give VBN cord-010119-t1x9gknd 9040 25 during during IN cord-010119-t1x9gknd 9040 26 the the DT cord-010119-t1x9gknd 9040 27 3 3 CD cord-010119-t1x9gknd 9040 28 month month NN cord-010119-t1x9gknd 9040 29 period period NN cord-010119-t1x9gknd 9040 30 ( ( -LRB- cord-010119-t1x9gknd 9040 31 P5 p5 NN cord-010119-t1x9gknd 9040 32 1.00 1.00 CD cord-010119-t1x9gknd 9040 33 ) ) -RRB- cord-010119-t1x9gknd 9040 34 . . . cord-010119-t1x9gknd 9041 1 The the DT cord-010119-t1x9gknd 9041 2 distribution distribution NN cord-010119-t1x9gknd 9041 3 by by IN cord-010119-t1x9gknd 9041 4 service service NN cord-010119-t1x9gknd 9041 5 was be VBD cord-010119-t1x9gknd 9041 6 different different JJ cord-010119-t1x9gknd 9041 7 for for IN cord-010119-t1x9gknd 9041 8 the the DT cord-010119-t1x9gknd 9041 9 groups group NNS cord-010119-t1x9gknd 9041 10 receiving receive VBG cord-010119-t1x9gknd 9041 11 multiple multiple JJ cord-010119-t1x9gknd 9041 12 units unit NNS cord-010119-t1x9gknd 9041 13 . . . cord-010119-t1x9gknd 9042 1 For for IN cord-010119-t1x9gknd 9042 2 single single JJ cord-010119-t1x9gknd 9042 3 units unit NNS cord-010119-t1x9gknd 9042 4 the the DT cord-010119-t1x9gknd 9042 5 distribution distribution NN cord-010119-t1x9gknd 9042 6 was be VBD cord-010119-t1x9gknd 9042 7 44 44 CD cord-010119-t1x9gknd 9042 8 % % NN cord-010119-t1x9gknd 9042 9 hematologic hematologic JJ cord-010119-t1x9gknd 9042 10 malignancy malignancy NN cord-010119-t1x9gknd 9042 11 , , , cord-010119-t1x9gknd 9042 12 22 22 CD cord-010119-t1x9gknd 9042 13 % % NN cord-010119-t1x9gknd 9042 14 infusion infusion NN cord-010119-t1x9gknd 9042 15 clinic clinic NN cord-010119-t1x9gknd 9042 16 ( ( -LRB- cord-010119-t1x9gknd 9042 17 NOS NOS NNP cord-010119-t1x9gknd 9042 18 ) ) -RRB- cord-010119-t1x9gknd 9042 19 , , , cord-010119-t1x9gknd 9042 20 13 13 CD cord-010119-t1x9gknd 9042 21 % % NN cord-010119-t1x9gknd 9042 22 solid solid JJ cord-010119-t1x9gknd 9042 23 tumor tumor NN cord-010119-t1x9gknd 9042 24 medicine medicine NN cord-010119-t1x9gknd 9042 25 , , , cord-010119-t1x9gknd 9042 26 11 11 CD cord-010119-t1x9gknd 9042 27 % % NN cord-010119-t1x9gknd 9042 28 surgery surgery NN cord-010119-t1x9gknd 9042 29 , , , cord-010119-t1x9gknd 9042 30 and and CC cord-010119-t1x9gknd 9042 31 9 9 CD cord-010119-t1x9gknd 9042 32 % % NN cord-010119-t1x9gknd 9042 33 pediatrics pediatric NNS cord-010119-t1x9gknd 9042 34 . . . cord-010119-t1x9gknd 9043 1 For for IN cord-010119-t1x9gknd 9043 2 those those DT cord-010119-t1x9gknd 9043 3 receiving receive VBG cord-010119-t1x9gknd 9043 4 multiple multiple JJ cord-010119-t1x9gknd 9043 5 units unit NNS cord-010119-t1x9gknd 9043 6 the the DT cord-010119-t1x9gknd 9043 7 distribution distribution NN cord-010119-t1x9gknd 9043 8 was be VBD cord-010119-t1x9gknd 9043 9 50 50 CD cord-010119-t1x9gknd 9043 10 % % NN cord-010119-t1x9gknd 9043 11 surgery surgery NN cord-010119-t1x9gknd 9043 12 and and CC cord-010119-t1x9gknd 9043 13 16 16 CD cord-010119-t1x9gknd 9043 14 % % NN cord-010119-t1x9gknd 9043 15 each each DT cord-010119-t1x9gknd 9043 16 for for IN cord-010119-t1x9gknd 9043 17 solid solid JJ cord-010119-t1x9gknd 9043 18 tumor tumor NN cord-010119-t1x9gknd 9043 19 , , , cord-010119-t1x9gknd 9043 20 hematology hematology NN cord-010119-t1x9gknd 9043 21 and and CC cord-010119-t1x9gknd 9043 22 infusion infusion NN cord-010119-t1x9gknd 9043 23 ( ( -LRB- cord-010119-t1x9gknd 9043 24 NOS NOS NNP cord-010119-t1x9gknd 9043 25 ) ) -RRB- cord-010119-t1x9gknd 9043 26 . . . cord-010119-t1x9gknd 9044 1 The the DT cord-010119-t1x9gknd 9044 2 chi chi JJ cord-010119-t1x9gknd 9044 3 - - JJ cord-010119-t1x9gknd 9044 4 square square JJ cord-010119-t1x9gknd 9044 5 test test NN cord-010119-t1x9gknd 9044 6 for for IN cord-010119-t1x9gknd 9044 7 associations association NNS cord-010119-t1x9gknd 9044 8 showed show VBD cord-010119-t1x9gknd 9044 9 the the DT cord-010119-t1x9gknd 9044 10 increase increase NN cord-010119-t1x9gknd 9044 11 in in IN cord-010119-t1x9gknd 9044 12 multiple multiple JJ cord-010119-t1x9gknd 9044 13 units unit NNS cord-010119-t1x9gknd 9044 14 to to IN cord-010119-t1x9gknd 9044 15 surgical surgical JJ cord-010119-t1x9gknd 9044 16 patients patient NNS cord-010119-t1x9gknd 9044 17 to to TO cord-010119-t1x9gknd 9044 18 be be VB cord-010119-t1x9gknd 9044 19 significant significant JJ cord-010119-t1x9gknd 9044 20 with with IN cord-010119-t1x9gknd 9044 21 a a DT cord-010119-t1x9gknd 9044 22 P p NN cord-010119-t1x9gknd 9044 23 value value NN cord-010119-t1x9gknd 9044 24 of of IN cord-010119-t1x9gknd 9044 25 0.022 0.022 CD cord-010119-t1x9gknd 9044 26 . . . cord-010119-t1x9gknd 9045 1 Conclusion conclusion NN cord-010119-t1x9gknd 9045 2 : : : cord-010119-t1x9gknd 9046 1 The the DT cord-010119-t1x9gknd 9046 2 distribution distribution NN cord-010119-t1x9gknd 9046 3 of of IN cord-010119-t1x9gknd 9046 4 the the DT cord-010119-t1x9gknd 9046 5 type type NN cord-010119-t1x9gknd 9046 6 of of IN cord-010119-t1x9gknd 9046 7 platelets platelet NNS cord-010119-t1x9gknd 9046 8 given give VBN cord-010119-t1x9gknd 9046 9 during during IN cord-010119-t1x9gknd 9046 10 a a DT cord-010119-t1x9gknd 9046 11 single single JJ cord-010119-t1x9gknd 9046 12 event event NN cord-010119-t1x9gknd 9046 13 of of IN cord-010119-t1x9gknd 9046 14 transfusion transfusion NN cord-010119-t1x9gknd 9046 15 was be VBD cord-010119-t1x9gknd 9046 16 not not RB cord-010119-t1x9gknd 9046 17 significantly significantly RB cord-010119-t1x9gknd 9046 18 different different JJ cord-010119-t1x9gknd 9046 19 from from IN cord-010119-t1x9gknd 9046 20 the the DT cord-010119-t1x9gknd 9046 21 overall overall JJ cord-010119-t1x9gknd 9046 22 distribution distribution NN cord-010119-t1x9gknd 9046 23 of of IN cord-010119-t1x9gknd 9046 24 platelets platelet NNS cord-010119-t1x9gknd 9046 25 given give VBN cord-010119-t1x9gknd 9046 26 during during IN cord-010119-t1x9gknd 9046 27 the the DT cord-010119-t1x9gknd 9046 28 3 3 CD cord-010119-t1x9gknd 9046 29 month month NN cord-010119-t1x9gknd 9046 30 period period NN cord-010119-t1x9gknd 9046 31 . . . cord-010119-t1x9gknd 9047 1 The the DT cord-010119-t1x9gknd 9047 2 patient patient NN cord-010119-t1x9gknd 9047 3 's 's POS cord-010119-t1x9gknd 9047 4 clinical clinical JJ cord-010119-t1x9gknd 9047 5 service service NN cord-010119-t1x9gknd 9047 6 was be VBD cord-010119-t1x9gknd 9047 7 a a DT cord-010119-t1x9gknd 9047 8 better well JJR cord-010119-t1x9gknd 9047 9 predictor predictor NN cord-010119-t1x9gknd 9047 10 of of IN cord-010119-t1x9gknd 9047 11 the the DT cord-010119-t1x9gknd 9047 12 use use NN cord-010119-t1x9gknd 9047 13 of of IN cord-010119-t1x9gknd 9047 14 multiple multiple JJ cord-010119-t1x9gknd 9047 15 products product NNS cord-010119-t1x9gknd 9047 16 than than IN cord-010119-t1x9gknd 9047 17 the the DT cord-010119-t1x9gknd 9047 18 type type NN cord-010119-t1x9gknd 9047 19 of of IN cord-010119-t1x9gknd 9047 20 product product NN cord-010119-t1x9gknd 9047 21 given give VBN cord-010119-t1x9gknd 9047 22 . . . cord-010119-t1x9gknd 9048 1 This this DT cord-010119-t1x9gknd 9048 2 suggests suggest VBZ cord-010119-t1x9gknd 9048 3 that that IN cord-010119-t1x9gknd 9048 4 surgical surgical JJ cord-010119-t1x9gknd 9048 5 losses loss NNS cord-010119-t1x9gknd 9048 6 or or CC cord-010119-t1x9gknd 9048 7 the the DT cord-010119-t1x9gknd 9048 8 need need NN cord-010119-t1x9gknd 9048 9 to to TO cord-010119-t1x9gknd 9048 10 have have VB cord-010119-t1x9gknd 9048 11 a a DT cord-010119-t1x9gknd 9048 12 higher high JJR cord-010119-t1x9gknd 9048 13 platelet platelet NN cord-010119-t1x9gknd 9048 14 count count NN cord-010119-t1x9gknd 9048 15 during during IN cord-010119-t1x9gknd 9048 16 a a DT cord-010119-t1x9gknd 9048 17 procedure procedure NN cord-010119-t1x9gknd 9048 18 was be VBD cord-010119-t1x9gknd 9048 19 the the DT cord-010119-t1x9gknd 9048 20 leading lead VBG cord-010119-t1x9gknd 9048 21 factor factor NN cord-010119-t1x9gknd 9048 22 in in IN cord-010119-t1x9gknd 9048 23 the the DT cord-010119-t1x9gknd 9048 24 use use NN cord-010119-t1x9gknd 9048 25 of of IN cord-010119-t1x9gknd 9048 26 multiple multiple JJ cord-010119-t1x9gknd 9048 27 products product NNS cord-010119-t1x9gknd 9048 28 in in IN cord-010119-t1x9gknd 9048 29 this this DT cord-010119-t1x9gknd 9048 30 transfusion transfusion NN cord-010119-t1x9gknd 9048 31 scenario scenario NN cord-010119-t1x9gknd 9048 32 . . . cord-010119-t1x9gknd 9049 1 The the DT cord-010119-t1x9gknd 9049 2 Effect Effect NNP cord-010119-t1x9gknd 9049 3 of of IN cord-010119-t1x9gknd 9049 4 Red Red NNP cord-010119-t1x9gknd 9049 5 Blood Blood NNP cord-010119-t1x9gknd 9049 6 Cell Cell NNP cord-010119-t1x9gknd 9049 7 Transfusion Transfusion NNP cord-010119-t1x9gknd 9049 8 on on IN cord-010119-t1x9gknd 9049 9 Iron Iron NNP cord-010119-t1x9gknd 9049 10 Metabolism Metabolism NNP cord-010119-t1x9gknd 9049 11 in in IN cord-010119-t1x9gknd 9049 12 Critically critically RB cord-010119-t1x9gknd 9049 13 Ill Ill NNP cord-010119-t1x9gknd 9049 14 Patients patient NNS cord-010119-t1x9gknd 9050 1 Margit Margit NNP cord-010119-t1x9gknd 9050 2 Boshuizen Boshuizen NNP cord-010119-t1x9gknd 9050 3 * * NFP cord-010119-t1x9gknd 9050 4 1,2 1,2 CD cord-010119-t1x9gknd 9050 5 , , , cord-010119-t1x9gknd 9050 6 Yvemarie Yvemarie NNP cord-010119-t1x9gknd 9050 7 B.O. B.O. NNP cord-010119-t1x9gknd 9050 8 Somsen Somsen NNP cord-010119-t1x9gknd 9050 9 2 2 CD cord-010119-t1x9gknd 9050 10 , , , cord-010119-t1x9gknd 9050 11 Maike Maike NNP cord-010119-t1x9gknd 9050 12 E. E. NNP cord-010119-t1x9gknd 9050 13 van van NNP cord-010119-t1x9gknd 9050 14 Hezel Hezel NNP cord-010119-t1x9gknd 9050 15 2 2 CD cord-010119-t1x9gknd 9050 16 , , , cord-010119-t1x9gknd 9050 17 Marleen Marleen NNP cord-010119-t1x9gknd 9050 18 Straat Straat NNP cord-010119-t1x9gknd 9050 19 2 2 CD cord-010119-t1x9gknd 9050 20 , , , cord-010119-t1x9gknd 9050 21 Robin Robin NNP cord-010119-t1x9gknd 9050 22 van van NNP cord-010119-t1x9gknd 9050 23 Bruggen Bruggen NNP cord-010119-t1x9gknd 9050 24 1 1 CD cord-010119-t1x9gknd 9050 25 and and CC cord-010119-t1x9gknd 9050 26 Nicole Nicole NNP cord-010119-t1x9gknd 9050 27 P P NNP cord-010119-t1x9gknd 9050 28 Juffermans Juffermans NNP cord-010119-t1x9gknd 9050 29 2 2 CD cord-010119-t1x9gknd 9050 30 . . . cord-010119-t1x9gknd 9050 31 1 1 CD cord-010119-t1x9gknd 9050 32 Sanquin Sanquin NNP cord-010119-t1x9gknd 9050 33 Research Research NNP cord-010119-t1x9gknd 9050 34 and and CC cord-010119-t1x9gknd 9050 35 Landsteiner Landsteiner NNP cord-010119-t1x9gknd 9050 36 Laboratory Laboratory NNP cord-010119-t1x9gknd 9050 37 , , , cord-010119-t1x9gknd 9050 38 2 2 CD cord-010119-t1x9gknd 9050 39 Academic Academic NNP cord-010119-t1x9gknd 9050 40 Medical Medical NNP cord-010119-t1x9gknd 9050 41 Center Center NNP cord-010119-t1x9gknd 9050 42 Background Background NNP cord-010119-t1x9gknd 9050 43 / / SYM cord-010119-t1x9gknd 9050 44 Case Case NNP cord-010119-t1x9gknd 9050 45 Studies Studies NNPS cord-010119-t1x9gknd 9050 46 : : : cord-010119-t1x9gknd 9050 47 Anemia anemia NN cord-010119-t1x9gknd 9050 48 of of IN cord-010119-t1x9gknd 9050 49 Inflammation inflammation NN cord-010119-t1x9gknd 9050 50 ( ( -LRB- cord-010119-t1x9gknd 9050 51 AI AI NNP cord-010119-t1x9gknd 9050 52 ) ) -RRB- cord-010119-t1x9gknd 9050 53 has have VBZ cord-010119-t1x9gknd 9050 54 a a DT cord-010119-t1x9gknd 9050 55 high high JJ cord-010119-t1x9gknd 9050 56 prevalence prevalence NN cord-010119-t1x9gknd 9050 57 in in IN cord-010119-t1x9gknd 9050 58 critically critically RB cord-010119-t1x9gknd 9050 59 ill ill JJ cord-010119-t1x9gknd 9050 60 patients patient NNS cord-010119-t1x9gknd 9050 61 . . . cord-010119-t1x9gknd 9051 1 In in IN cord-010119-t1x9gknd 9051 2 AI AI NNP cord-010119-t1x9gknd 9051 3 , , , cord-010119-t1x9gknd 9051 4 iron iron NN cord-010119-t1x9gknd 9051 5 metabolism metabolism NN cord-010119-t1x9gknd 9051 6 is be VBZ cord-010119-t1x9gknd 9051 7 altered alter VBN cord-010119-t1x9gknd 9051 8 , , , cord-010119-t1x9gknd 9051 9 as as IN cord-010119-t1x9gknd 9051 10 high high JJ cord-010119-t1x9gknd 9051 11 levels level NNS cord-010119-t1x9gknd 9051 12 of of IN cord-010119-t1x9gknd 9051 13 inflammation inflammation NN cord-010119-t1x9gknd 9051 14 - - HYPH cord-010119-t1x9gknd 9051 15 induced induce VBN cord-010119-t1x9gknd 9051 16 hepcidin hepcidin NNP cord-010119-t1x9gknd 9051 17 reduces reduce VBZ cord-010119-t1x9gknd 9051 18 the the DT cord-010119-t1x9gknd 9051 19 amount amount NN cord-010119-t1x9gknd 9051 20 of of IN cord-010119-t1x9gknd 9051 21 iron iron NN cord-010119-t1x9gknd 9051 22 that that WDT cord-010119-t1x9gknd 9051 23 is be VBZ cord-010119-t1x9gknd 9051 24 available available JJ cord-010119-t1x9gknd 9051 25 for for IN cord-010119-t1x9gknd 9051 26 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 9051 27 . . . cord-010119-t1x9gknd 9052 1 AI AI NNP cord-010119-t1x9gknd 9052 2 is be VBZ cord-010119-t1x9gknd 9052 3 treated treat VBN cord-010119-t1x9gknd 9052 4 by by IN cord-010119-t1x9gknd 9052 5 red red JJ cord-010119-t1x9gknd 9052 6 blood blood NN cord-010119-t1x9gknd 9052 7 cell cell NN cord-010119-t1x9gknd 9052 8 ( ( -LRB- cord-010119-t1x9gknd 9052 9 RBC RBC NNP cord-010119-t1x9gknd 9052 10 ) ) -RRB- cord-010119-t1x9gknd 9052 11 transfusions transfusion NNS cord-010119-t1x9gknd 9052 12 . . . cord-010119-t1x9gknd 9053 1 It -PRON- PRP cord-010119-t1x9gknd 9053 2 is be VBZ cord-010119-t1x9gknd 9053 3 known know VBN cord-010119-t1x9gknd 9053 4 that that IN cord-010119-t1x9gknd 9053 5 RBC RBC NNP cord-010119-t1x9gknd 9053 6 transfusions transfusion NNS cord-010119-t1x9gknd 9053 7 increase increase VBP cord-010119-t1x9gknd 9053 8 iron iron NN cord-010119-t1x9gknd 9053 9 level level NN cord-010119-t1x9gknd 9053 10 in in IN cord-010119-t1x9gknd 9053 11 neonates neonate NNS cord-010119-t1x9gknd 9053 12 and and CC cord-010119-t1x9gknd 9053 13 thalassemia thalassemia NN cord-010119-t1x9gknd 9053 14 patients patient NNS cord-010119-t1x9gknd 9053 15 , , , cord-010119-t1x9gknd 9053 16 but but CC cord-010119-t1x9gknd 9053 17 the the DT cord-010119-t1x9gknd 9053 18 effect effect NN cord-010119-t1x9gknd 9053 19 of of IN cord-010119-t1x9gknd 9053 20 RBC RBC NNP cord-010119-t1x9gknd 9053 21 transfusion transfusion NN cord-010119-t1x9gknd 9053 22 on on IN cord-010119-t1x9gknd 9053 23 iron iron NN cord-010119-t1x9gknd 9053 24 metabolism metabolism NN cord-010119-t1x9gknd 9053 25 during during IN cord-010119-t1x9gknd 9053 26 inflammatory inflammatory JJ cord-010119-t1x9gknd 9053 27 processes process NNS cord-010119-t1x9gknd 9053 28 is be VBZ cord-010119-t1x9gknd 9053 29 unknown unknown JJ cord-010119-t1x9gknd 9053 30 . . . cord-010119-t1x9gknd 9054 1 Since since IN cord-010119-t1x9gknd 9054 2 one one CD cord-010119-t1x9gknd 9054 3 unit unit NN cord-010119-t1x9gknd 9054 4 of of IN cord-010119-t1x9gknd 9054 5 RBCs rbc NNS cord-010119-t1x9gknd 9054 6 contains contain VBZ cord-010119-t1x9gknd 9054 7 220 220 CD cord-010119-t1x9gknd 9054 8 mg mg NN cord-010119-t1x9gknd 9054 9 of of IN cord-010119-t1x9gknd 9054 10 iron iron NN cord-010119-t1x9gknd 9054 11 and and CC cord-010119-t1x9gknd 9054 12 25 25 CD cord-010119-t1x9gknd 9054 13 % % NN cord-010119-t1x9gknd 9054 14 of of IN cord-010119-t1x9gknd 9054 15 the the DT cord-010119-t1x9gknd 9054 16 RBCs rbc NNS cord-010119-t1x9gknd 9054 17 are be VBP cord-010119-t1x9gknd 9054 18 cleared clear VBN cord-010119-t1x9gknd 9054 19 by by IN cord-010119-t1x9gknd 9054 20 macrophages macrophage NNS cord-010119-t1x9gknd 9054 21 within within IN cord-010119-t1x9gknd 9054 22 1 1 CD cord-010119-t1x9gknd 9054 23 hour hour NN cord-010119-t1x9gknd 9054 24 following follow VBG cord-010119-t1x9gknd 9054 25 transfusion transfusion NN cord-010119-t1x9gknd 9054 26 , , , cord-010119-t1x9gknd 9054 27 RBC RBC NNP cord-010119-t1x9gknd 9054 28 transfusion transfusion NN cord-010119-t1x9gknd 9054 29 could could MD cord-010119-t1x9gknd 9054 30 increase increase VB cord-010119-t1x9gknd 9054 31 iron iron NN cord-010119-t1x9gknd 9054 32 levels level NNS cord-010119-t1x9gknd 9054 33 and and CC cord-010119-t1x9gknd 9054 34 iron iron NN cord-010119-t1x9gknd 9054 35 availability availability NN cord-010119-t1x9gknd 9054 36 for for IN cord-010119-t1x9gknd 9054 37 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 9054 38 . . . cord-010119-t1x9gknd 9055 1 We -PRON- PRP cord-010119-t1x9gknd 9055 2 investigated investigate VBD cord-010119-t1x9gknd 9055 3 the the DT cord-010119-t1x9gknd 9055 4 effect effect NN cord-010119-t1x9gknd 9055 5 of of IN cord-010119-t1x9gknd 9055 6 RBC RBC NNP cord-010119-t1x9gknd 9055 7 transfusion transfusion NN cord-010119-t1x9gknd 9055 8 on on IN cord-010119-t1x9gknd 9055 9 iron iron NN cord-010119-t1x9gknd 9055 10 metabolism metabolism NN cord-010119-t1x9gknd 9055 11 in in IN cord-010119-t1x9gknd 9055 12 ICU ICU NNP cord-010119-t1x9gknd 9055 13 patients patient NNS cord-010119-t1x9gknd 9055 14 , , , cord-010119-t1x9gknd 9055 15 and and CC cord-010119-t1x9gknd 9055 16 additionally additionally RB cord-010119-t1x9gknd 9055 17 compared compare VBD cord-010119-t1x9gknd 9055 18 the the DT cord-010119-t1x9gknd 9055 19 effect effect NN cord-010119-t1x9gknd 9055 20 in in IN cord-010119-t1x9gknd 9055 21 septic septic JJ cord-010119-t1x9gknd 9055 22 patients patient NNS cord-010119-t1x9gknd 9055 23 to to IN cord-010119-t1x9gknd 9055 24 non non JJ cord-010119-t1x9gknd 9055 25 - - JJ cord-010119-t1x9gknd 9055 26 septic septic JJ cord-010119-t1x9gknd 9055 27 patients patient NNS cord-010119-t1x9gknd 9055 28 . . . cord-010119-t1x9gknd 9056 1 Study Study NNP cord-010119-t1x9gknd 9056 2 Design Design NNP cord-010119-t1x9gknd 9056 3 / / SYM cord-010119-t1x9gknd 9056 4 Method method NN cord-010119-t1x9gknd 9056 5 : : : cord-010119-t1x9gknd 9057 1 In in IN cord-010119-t1x9gknd 9057 2 a a DT cord-010119-t1x9gknd 9057 3 prospective prospective JJ cord-010119-t1x9gknd 9057 4 cohort cohort NN cord-010119-t1x9gknd 9057 5 study study NN cord-010119-t1x9gknd 9057 6 in in IN cord-010119-t1x9gknd 9057 7 52 52 CD cord-010119-t1x9gknd 9057 8 ICU ICU NNP cord-010119-t1x9gknd 9057 9 patients patient NNS cord-010119-t1x9gknd 9057 10 who who WP cord-010119-t1x9gknd 9057 11 received receive VBD cord-010119-t1x9gknd 9057 12 one one CD cord-010119-t1x9gknd 9057 13 RBC RBC NNP cord-010119-t1x9gknd 9057 14 transfusion transfusion NN cord-010119-t1x9gknd 9057 15 , , , cord-010119-t1x9gknd 9057 16 different different JJ cord-010119-t1x9gknd 9057 17 iron iron NN cord-010119-t1x9gknd 9057 18 parameters parameter NNS cord-010119-t1x9gknd 9057 19 were be VBD cord-010119-t1x9gknd 9057 20 measured measure VBN cord-010119-t1x9gknd 9057 21 before before RB cord-010119-t1x9gknd 9057 22 and and CC cord-010119-t1x9gknd 9057 23 24 24 CD cord-010119-t1x9gknd 9057 24 hours hour NNS cord-010119-t1x9gknd 9057 25 after after IN cord-010119-t1x9gknd 9057 26 transfusion transfusion NN cord-010119-t1x9gknd 9057 27 , , , cord-010119-t1x9gknd 9057 28 to to TO cord-010119-t1x9gknd 9057 29 determine determine VB cord-010119-t1x9gknd 9057 30 the the DT cord-010119-t1x9gknd 9057 31 effect effect NN cord-010119-t1x9gknd 9057 32 of of IN cord-010119-t1x9gknd 9057 33 a a DT cord-010119-t1x9gknd 9057 34 RBC RBC NNP cord-010119-t1x9gknd 9057 35 transfusion transfusion NN cord-010119-t1x9gknd 9057 36 over over IN cord-010119-t1x9gknd 9057 37 a a DT cord-010119-t1x9gknd 9057 38 period period NN cord-010119-t1x9gknd 9057 39 of of IN cord-010119-t1x9gknd 9057 40 time time NN cord-010119-t1x9gknd 9057 41 . . . cord-010119-t1x9gknd 9058 1 Next next RB cord-010119-t1x9gknd 9058 2 , , , cord-010119-t1x9gknd 9058 3 the the DT cord-010119-t1x9gknd 9058 4 impact impact NN cord-010119-t1x9gknd 9058 5 of of IN cord-010119-t1x9gknd 9058 6 a a DT cord-010119-t1x9gknd 9058 7 RBC RBC NNP cord-010119-t1x9gknd 9058 8 transfusion transfusion NN cord-010119-t1x9gknd 9058 9 on on IN cord-010119-t1x9gknd 9058 10 plasma plasma NN cord-010119-t1x9gknd 9058 11 iron iron NN cord-010119-t1x9gknd 9058 12 parameters parameter NNS cord-010119-t1x9gknd 9058 13 in in IN cord-010119-t1x9gknd 9058 14 septic septic JJ cord-010119-t1x9gknd 9058 15 patients patient NNS cord-010119-t1x9gknd 9058 16 compared compare VBN cord-010119-t1x9gknd 9058 17 to to IN cord-010119-t1x9gknd 9058 18 that that DT cord-010119-t1x9gknd 9058 19 in in IN cord-010119-t1x9gknd 9058 20 non non JJ cord-010119-t1x9gknd 9058 21 - - JJ cord-010119-t1x9gknd 9058 22 septic septic JJ cord-010119-t1x9gknd 9058 23 patients patient NNS cord-010119-t1x9gknd 9058 24 was be VBD cord-010119-t1x9gknd 9058 25 analyzed analyze VBN cord-010119-t1x9gknd 9058 26 . . . cord-010119-t1x9gknd 9059 1 Plasma plasma NN cord-010119-t1x9gknd 9059 2 iron iron NN cord-010119-t1x9gknd 9059 3 concentration concentration NN cord-010119-t1x9gknd 9059 4 , , , cord-010119-t1x9gknd 9059 5 transferrin transferrin NN cord-010119-t1x9gknd 9059 6 ( ( -LRB- cord-010119-t1x9gknd 9059 7 saturation saturation NN cord-010119-t1x9gknd 9059 8 ) ) -RRB- cord-010119-t1x9gknd 9059 9 , , , cord-010119-t1x9gknd 9059 10 ferritin ferritin NN cord-010119-t1x9gknd 9059 11 , , , cord-010119-t1x9gknd 9059 12 haptoglobin haptoglobin NN cord-010119-t1x9gknd 9059 13 , , , cord-010119-t1x9gknd 9059 14 hepcidin hepcidin NNP cord-010119-t1x9gknd 9059 15 and and CC cord-010119-t1x9gknd 9059 16 IL-6 IL-6 NNP cord-010119-t1x9gknd 9059 17 levels level NNS cord-010119-t1x9gknd 9059 18 were be VBD cord-010119-t1x9gknd 9059 19 determined determine VBN cord-010119-t1x9gknd 9059 20 . . . cord-010119-t1x9gknd 9060 1 Results result NNS cord-010119-t1x9gknd 9060 2 / / SYM cord-010119-t1x9gknd 9060 3 Finding finding NN cord-010119-t1x9gknd 9060 4 : : : cord-010119-t1x9gknd 9061 1 In in IN cord-010119-t1x9gknd 9061 2 this this DT cord-010119-t1x9gknd 9061 3 cohort cohort NN cord-010119-t1x9gknd 9061 4 , , , cord-010119-t1x9gknd 9061 5 serum serum NN cord-010119-t1x9gknd 9061 6 iron iron NN cord-010119-t1x9gknd 9061 7 levels level NNS cord-010119-t1x9gknd 9061 8 were be VBD cord-010119-t1x9gknd 9061 9 low low JJ cord-010119-t1x9gknd 9061 10 and and CC cord-010119-t1x9gknd 9061 11 did do VBD cord-010119-t1x9gknd 9061 12 not not RB cord-010119-t1x9gknd 9061 13 change change VB cord-010119-t1x9gknd 9061 14 following follow VBG cord-010119-t1x9gknd 9061 15 transfusion transfusion NN cord-010119-t1x9gknd 9061 16 ( ( -LRB- cord-010119-t1x9gknd 9061 17 4.1 4.1 CD cord-010119-t1x9gknd 9061 18 vs. vs. NN cord-010119-t1x9gknd 9061 19 4.3 4.3 CD cord-010119-t1x9gknd 9061 20 mmol mmol JJ cord-010119-t1x9gknd 9061 21 / / SYM cord-010119-t1x9gknd 9061 22 L L NNP cord-010119-t1x9gknd 9061 23 , , , cord-010119-t1x9gknd 9061 24 p50.69 p50.69 NNP cord-010119-t1x9gknd 9061 25 ) ) -RRB- cord-010119-t1x9gknd 9061 26 . . . cord-010119-t1x9gknd 9062 1 Also also RB cord-010119-t1x9gknd 9062 2 , , , cord-010119-t1x9gknd 9062 3 the the DT cord-010119-t1x9gknd 9062 4 transfusion transfusion NN cord-010119-t1x9gknd 9062 5 had have VBD cord-010119-t1x9gknd 9062 6 no no DT cord-010119-t1x9gknd 9062 7 effect effect NN cord-010119-t1x9gknd 9062 8 on on IN cord-010119-t1x9gknd 9062 9 transferrin transferrin NN cord-010119-t1x9gknd 9062 10 saturation saturation NN cord-010119-t1x9gknd 9062 11 ( ( -LRB- cord-010119-t1x9gknd 9062 12 12 12 CD cord-010119-t1x9gknd 9062 13 vs. vs. CC cord-010119-t1x9gknd 9062 14 13 13 CD cord-010119-t1x9gknd 9062 15 % % NN cord-010119-t1x9gknd 9062 16 , , , cord-010119-t1x9gknd 9062 17 p50.13 p50.13 NNP cord-010119-t1x9gknd 9062 18 ) ) -RRB- cord-010119-t1x9gknd 9062 19 , , , cord-010119-t1x9gknd 9062 20 ferritin ferritin NN cord-010119-t1x9gknd 9062 21 ( ( -LRB- cord-010119-t1x9gknd 9062 22 531.0 531.0 CD cord-010119-t1x9gknd 9062 23 vs. vs. IN cord-010119-t1x9gknd 9062 24 599.0 599.0 CD cord-010119-t1x9gknd 9062 25 mg mg NNP cord-010119-t1x9gknd 9062 26 / / SYM cord-010119-t1x9gknd 9062 27 L L NNP cord-010119-t1x9gknd 9062 28 , , , cord-010119-t1x9gknd 9062 29 p50.74 p50.74 NNP cord-010119-t1x9gknd 9062 30 ) ) -RRB- cord-010119-t1x9gknd 9062 31 and and CC cord-010119-t1x9gknd 9062 32 IL-6 IL-6 NNP cord-010119-t1x9gknd 9062 33 levels level NNS cord-010119-t1x9gknd 9062 34 ( ( -LRB- cord-010119-t1x9gknd 9062 35 35.0 35.0 CD cord-010119-t1x9gknd 9062 36 vs. vs. IN cord-010119-t1x9gknd 9062 37 25.5 25.5 CD cord-010119-t1x9gknd 9062 38 pg pg NNP cord-010119-t1x9gknd 9062 39 / / SYM cord-010119-t1x9gknd 9062 40 ml ml NNS cord-010119-t1x9gknd 9062 41 , , , cord-010119-t1x9gknd 9062 42 p50.09 p50.09 JJ cord-010119-t1x9gknd 9062 43 ) ) -RRB- cord-010119-t1x9gknd 9062 44 . . . cord-010119-t1x9gknd 9063 1 Hepcidin Hepcidin NNP cord-010119-t1x9gknd 9063 2 levels level NNS cord-010119-t1x9gknd 9063 3 increased increase VBD cord-010119-t1x9gknd 9063 4 in in IN cord-010119-t1x9gknd 9063 5 these these DT cord-010119-t1x9gknd 9063 6 ICU ICU NNP cord-010119-t1x9gknd 9063 7 patients patient NNS cord-010119-t1x9gknd 9063 8 after after IN cord-010119-t1x9gknd 9063 9 RBC RBC NNP cord-010119-t1x9gknd 9063 10 transfusion transfusion NN cord-010119-t1x9gknd 9063 11 ( ( -LRB- cord-010119-t1x9gknd 9063 12 223 223 CD cord-010119-t1x9gknd 9063 13 vs vs IN cord-010119-t1x9gknd 9063 14 332 332 CD cord-010119-t1x9gknd 9063 15 ng ng NNP cord-010119-t1x9gknd 9063 16 / / SYM cord-010119-t1x9gknd 9063 17 ml ml NN cord-010119-t1x9gknd 9063 18 , , , cord-010119-t1x9gknd 9063 19 p50.01 p50.01 NNP cord-010119-t1x9gknd 9063 20 ) ) -RRB- cord-010119-t1x9gknd 9063 21 . . . cord-010119-t1x9gknd 9064 1 In in IN cord-010119-t1x9gknd 9064 2 septic septic JJ cord-010119-t1x9gknd 9064 3 patients patient NNS cord-010119-t1x9gknd 9064 4 , , , cord-010119-t1x9gknd 9064 5 RBC RBC NNP cord-010119-t1x9gknd 9064 6 transfusion transfusion NN cord-010119-t1x9gknd 9064 7 induced induce VBD cord-010119-t1x9gknd 9064 8 a a DT cord-010119-t1x9gknd 9064 9 decrease decrease NN cord-010119-t1x9gknd 9064 10 in in IN cord-010119-t1x9gknd 9064 11 haptoglobin haptoglobin NN cord-010119-t1x9gknd 9064 12 levels level NNS cord-010119-t1x9gknd 9064 13 compared compare VBN cord-010119-t1x9gknd 9064 14 to to IN cord-010119-t1x9gknd 9064 15 baseline baseline NN cord-010119-t1x9gknd 9064 16 , , , cord-010119-t1x9gknd 9064 17 which which WDT cord-010119-t1x9gknd 9064 18 did do VBD cord-010119-t1x9gknd 9064 19 not not RB cord-010119-t1x9gknd 9064 20 occur occur VB cord-010119-t1x9gknd 9064 21 in in IN cord-010119-t1x9gknd 9064 22 non non JJ cord-010119-t1x9gknd 9064 23 - - JJ cord-010119-t1x9gknd 9064 24 septic septic JJ cord-010119-t1x9gknd 9064 25 patients patient NNS cord-010119-t1x9gknd 9064 26 ( ( -LRB- cord-010119-t1x9gknd 9064 27 -2.7 -2.7 NN cord-010119-t1x9gknd 9064 28 vs. vs. IN cord-010119-t1x9gknd 9064 29 3.7 3.7 CD cord-010119-t1x9gknd 9064 30 % % NN cord-010119-t1x9gknd 9064 31 change change NN cord-010119-t1x9gknd 9064 32 , , , cord-010119-t1x9gknd 9064 33 p50.05 p50.05 NNP cord-010119-t1x9gknd 9064 34 ) ) -RRB- cord-010119-t1x9gknd 9064 35 . . . cord-010119-t1x9gknd 9065 1 Other other JJ cord-010119-t1x9gknd 9065 2 iron iron NN cord-010119-t1x9gknd 9065 3 parameters parameter NNS cord-010119-t1x9gknd 9065 4 did do VBD cord-010119-t1x9gknd 9065 5 not not RB cord-010119-t1x9gknd 9065 6 differ differ VB cord-010119-t1x9gknd 9065 7 between between IN cord-010119-t1x9gknd 9065 8 septic septic JJ cord-010119-t1x9gknd 9065 9 and and CC cord-010119-t1x9gknd 9065 10 non non JJ cord-010119-t1x9gknd 9065 11 - - JJ cord-010119-t1x9gknd 9065 12 septic septic JJ cord-010119-t1x9gknd 9065 13 patients patient NNS cord-010119-t1x9gknd 9065 14 . . . cord-010119-t1x9gknd 9066 1 Conclusion conclusion NN cord-010119-t1x9gknd 9066 2 : : : cord-010119-t1x9gknd 9067 1 Transfusion transfusion NN cord-010119-t1x9gknd 9067 2 of of IN cord-010119-t1x9gknd 9067 3 one one CD cord-010119-t1x9gknd 9067 4 unit unit NN cord-010119-t1x9gknd 9067 5 of of IN cord-010119-t1x9gknd 9067 6 RBCs rbc NNS cord-010119-t1x9gknd 9067 7 does do VBZ cord-010119-t1x9gknd 9067 8 not not RB cord-010119-t1x9gknd 9067 9 increase increase VB cord-010119-t1x9gknd 9067 10 iron iron NN cord-010119-t1x9gknd 9067 11 levels level NNS cord-010119-t1x9gknd 9067 12 in in IN cord-010119-t1x9gknd 9067 13 ICU ICU NNP cord-010119-t1x9gknd 9067 14 patients patient NNS cord-010119-t1x9gknd 9067 15 . . . cord-010119-t1x9gknd 9068 1 The the DT cord-010119-t1x9gknd 9068 2 increase increase NN cord-010119-t1x9gknd 9068 3 of of IN cord-010119-t1x9gknd 9068 4 hepcidin hepcidin NNP cord-010119-t1x9gknd 9068 5 suggests suggest VBZ cord-010119-t1x9gknd 9068 6 RBC RBC NNP cord-010119-t1x9gknd 9068 7 transfusion transfusion NN cord-010119-t1x9gknd 9068 8 induced induce VBN cord-010119-t1x9gknd 9068 9 upregulation upregulation NN cord-010119-t1x9gknd 9068 10 of of IN cord-010119-t1x9gknd 9068 11 hepcidin hepcidin NNP cord-010119-t1x9gknd 9068 12 , , , cord-010119-t1x9gknd 9068 13 despite despite IN cord-010119-t1x9gknd 9068 14 the the DT cord-010119-t1x9gknd 9068 15 absence absence NN cord-010119-t1x9gknd 9068 16 of of IN cord-010119-t1x9gknd 9068 17 a a DT cord-010119-t1x9gknd 9068 18 significant significant JJ cord-010119-t1x9gknd 9068 19 increase increase NN cord-010119-t1x9gknd 9068 20 in in IN cord-010119-t1x9gknd 9068 21 IL-6 IL-6 NNP cord-010119-t1x9gknd 9068 22 or or CC cord-010119-t1x9gknd 9068 23 plasma plasma NN cord-010119-t1x9gknd 9068 24 iron iron NN cord-010119-t1x9gknd 9068 25 levels level NNS cord-010119-t1x9gknd 9068 26 . . . cord-010119-t1x9gknd 9069 1 This this DT cord-010119-t1x9gknd 9069 2 increase increase NN cord-010119-t1x9gknd 9069 3 in in IN cord-010119-t1x9gknd 9069 4 hepcidin hepcidin NN cord-010119-t1x9gknd 9069 5 levels level NNS cord-010119-t1x9gknd 9069 6 after after IN cord-010119-t1x9gknd 9069 7 transfusion transfusion NN cord-010119-t1x9gknd 9069 8 can can MD cord-010119-t1x9gknd 9069 9 potentially potentially RB cord-010119-t1x9gknd 9069 10 further further RB cord-010119-t1x9gknd 9069 11 hamper hamper NN cord-010119-t1x9gknd 9069 12 iron iron NN cord-010119-t1x9gknd 9069 13 availability availability NN cord-010119-t1x9gknd 9069 14 for for IN cord-010119-t1x9gknd 9069 15 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 9069 16 . . . cord-010119-t1x9gknd 9070 1 In in IN cord-010119-t1x9gknd 9070 2 sepsis sepsis NN cord-010119-t1x9gknd 9070 3 , , , cord-010119-t1x9gknd 9070 4 RBC RBC NNP cord-010119-t1x9gknd 9070 5 transfusion transfusion NN cord-010119-t1x9gknd 9070 6 decreases decrease VBZ cord-010119-t1x9gknd 9070 7 haptoglobin haptoglobin NN cord-010119-t1x9gknd 9070 8 levels level NNS cord-010119-t1x9gknd 9070 9 , , , cord-010119-t1x9gknd 9070 10 suggestive suggestive JJ cord-010119-t1x9gknd 9070 11 of of IN cord-010119-t1x9gknd 9070 12 hemolysis hemolysis NN cord-010119-t1x9gknd 9070 13 . . . cord-010119-t1x9gknd 9071 1 In in IN cord-010119-t1x9gknd 9071 2 conclusion conclusion NN cord-010119-t1x9gknd 9071 3 , , , cord-010119-t1x9gknd 9071 4 RBC RBC NNP cord-010119-t1x9gknd 9071 5 transfusion transfusion NN cord-010119-t1x9gknd 9071 6 might may MD cord-010119-t1x9gknd 9071 7 have have VB cord-010119-t1x9gknd 9071 8 a a DT cord-010119-t1x9gknd 9071 9 negative negative JJ cord-010119-t1x9gknd 9071 10 effect effect NN cord-010119-t1x9gknd 9071 11 on on IN cord-010119-t1x9gknd 9071 12 erythropoiesis erythropoiesis NN cord-010119-t1x9gknd 9071 13 , , , cord-010119-t1x9gknd 9071 14 due due IN cord-010119-t1x9gknd 9071 15 to to IN cord-010119-t1x9gknd 9071 16 the the DT cord-010119-t1x9gknd 9071 17 increase increase NN cord-010119-t1x9gknd 9071 18 in in IN cord-010119-t1x9gknd 9071 19 hepcidin hepcidin NNP cord-010119-t1x9gknd 9071 20 levels level NNS cord-010119-t1x9gknd 9071 21 that that WDT cord-010119-t1x9gknd 9071 22 are be VBP cord-010119-t1x9gknd 9071 23 observed observe VBN cord-010119-t1x9gknd 9071 24 after after IN cord-010119-t1x9gknd 9071 25 transfusion transfusion NN cord-010119-t1x9gknd 9071 26 . . . cord-010119-t1x9gknd 9072 1 The the DT cord-010119-t1x9gknd 9072 2 Effects effect NNS cord-010119-t1x9gknd 9072 3 of of IN cord-010119-t1x9gknd 9072 4 PAS pas NN cord-010119-t1x9gknd 9072 5 and and CC cord-010119-t1x9gknd 9072 6 PR PR NNP cord-010119-t1x9gknd 9072 7 on on IN cord-010119-t1x9gknd 9072 8 Platelet platelet NN cord-010119-t1x9gknd 9072 9 Use Use NNP cord-010119-t1x9gknd 9072 10 Barbara Barbara NNP cord-010119-t1x9gknd 9072 11 Mendez Mendez NNP cord-010119-t1x9gknd 9072 12 , , , cord-010119-t1x9gknd 9072 13 Judith Judith NNP cord-010119-t1x9gknd 9072 14 DelMonte DelMonte NNP cord-010119-t1x9gknd 9072 15 , , , cord-010119-t1x9gknd 9072 16 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 9072 17 McCabe McCabe NNP cord-010119-t1x9gknd 9072 18 and and CC cord-010119-t1x9gknd 9072 19 Joanne Joanne NNP cord-010119-t1x9gknd 9072 20 Becker Becker NNP cord-010119-t1x9gknd 9073 1 * * NFP cord-010119-t1x9gknd 9073 2 . . . cord-010119-t1x9gknd 9074 1 Roswell Roswell NNP cord-010119-t1x9gknd 9074 2 Park Park NNP cord-010119-t1x9gknd 9074 3 Cancer Cancer NNP cord-010119-t1x9gknd 9074 4 Institute Institute NNP cord-010119-t1x9gknd 9074 5 Background Background NNP cord-010119-t1x9gknd 9074 6 / / SYM cord-010119-t1x9gknd 9074 7 Case Case NNP cord-010119-t1x9gknd 9074 8 Studies Studies NNPS cord-010119-t1x9gknd 9074 9 : : : cord-010119-t1x9gknd 9075 1 With with IN cord-010119-t1x9gknd 9075 2 the the DT cord-010119-t1x9gknd 9075 3 anticipated anticipated JJ cord-010119-t1x9gknd 9075 4 release release NN cord-010119-t1x9gknd 9075 5 of of IN cord-010119-t1x9gknd 9075 6 the the DT cord-010119-t1x9gknd 9075 7 FDA FDA NNP cord-010119-t1x9gknd 9075 8 guidance guidance NN cord-010119-t1x9gknd 9075 9 : : : cord-010119-t1x9gknd 9075 10 Bacterial bacterial JJ cord-010119-t1x9gknd 9075 11 Risk Risk NNP cord-010119-t1x9gknd 9075 12 Control Control NNP cord-010119-t1x9gknd 9075 13 Strategies Strategies NNPS cord-010119-t1x9gknd 9075 14 for for IN cord-010119-t1x9gknd 9075 15 Blood Blood NNP cord-010119-t1x9gknd 9075 16 Collection Collection NNP cord-010119-t1x9gknd 9075 17 Establishments Establishments NNPS cord-010119-t1x9gknd 9075 18 and and CC cord-010119-t1x9gknd 9075 19 Transfusion Transfusion NNP cord-010119-t1x9gknd 9075 20 Services Services NNPS cord-010119-t1x9gknd 9075 21 to to TO cord-010119-t1x9gknd 9075 22 Enhance enhance VB cord-010119-t1x9gknd 9075 23 the the DT cord-010119-t1x9gknd 9075 24 Safety Safety NNP cord-010119-t1x9gknd 9075 25 and and CC cord-010119-t1x9gknd 9075 26 Availability availability NN cord-010119-t1x9gknd 9075 27 of of IN cord-010119-t1x9gknd 9075 28 Platelets Platelets NNPS cord-010119-t1x9gknd 9075 29 for for IN cord-010119-t1x9gknd 9075 30 Transfusion Transfusion NNP cord-010119-t1x9gknd 9075 31 , , , cord-010119-t1x9gknd 9075 32 the the DT cord-010119-t1x9gknd 9075 33 use use NN cord-010119-t1x9gknd 9075 34 of of IN cord-010119-t1x9gknd 9075 35 pathogen pathogen NN cord-010119-t1x9gknd 9075 36 reduced reduce VBN cord-010119-t1x9gknd 9075 37 platelets platelet NNS cord-010119-t1x9gknd 9075 38 ( ( -LRB- cord-010119-t1x9gknd 9075 39 PR PR NNP cord-010119-t1x9gknd 9075 40 ) ) -RRB- cord-010119-t1x9gknd 9075 41 which which WDT cord-010119-t1x9gknd 9075 42 are be VBP cord-010119-t1x9gknd 9075 43 often often RB cord-010119-t1x9gknd 9075 44 produced produce VBN cord-010119-t1x9gknd 9075 45 from from IN cord-010119-t1x9gknd 9075 46 products product NNS cord-010119-t1x9gknd 9075 47 made make VBN cord-010119-t1x9gknd 9075 48 with with IN cord-010119-t1x9gknd 9075 49 platelet platelet NN cord-010119-t1x9gknd 9075 50 additive additive NN cord-010119-t1x9gknd 9075 51 solution solution NN cord-010119-t1x9gknd 9075 52 ( ( -LRB- cord-010119-t1x9gknd 9075 53 PAS pas NN cord-010119-t1x9gknd 9075 54 ) ) -RRB- cord-010119-t1x9gknd 9075 55 may may MD cord-010119-t1x9gknd 9075 56 become become VB cord-010119-t1x9gknd 9075 57 more more RBR cord-010119-t1x9gknd 9075 58 common common JJ cord-010119-t1x9gknd 9075 59 . . . cord-010119-t1x9gknd 9076 1 Our -PRON- PRP$ cord-010119-t1x9gknd 9076 2 institution institution NN cord-010119-t1x9gknd 9076 3 has have VBZ cord-010119-t1x9gknd 9076 4 been be VBN cord-010119-t1x9gknd 9076 5 transfusing transfuse VBG cord-010119-t1x9gknd 9076 6 platelets platelet NNS cord-010119-t1x9gknd 9076 7 made make VBN cord-010119-t1x9gknd 9076 8 with with IN cord-010119-t1x9gknd 9076 9 additive additive NN cord-010119-t1x9gknd 9076 10 solutions solution NNS cord-010119-t1x9gknd 9076 11 since since IN cord-010119-t1x9gknd 9076 12 2011 2011 CD cord-010119-t1x9gknd 9076 13 and and CC cord-010119-t1x9gknd 9076 14 pathogen pathogen NN cord-010119-t1x9gknd 9076 15 reduced reduce VBN cord-010119-t1x9gknd 9076 16 platelets platelet NNS cord-010119-t1x9gknd 9076 17 have have VBP cord-010119-t1x9gknd 9076 18 been be VBN cord-010119-t1x9gknd 9076 19 available available JJ cord-010119-t1x9gknd 9076 20 since since IN cord-010119-t1x9gknd 9076 21 2016 2016 CD cord-010119-t1x9gknd 9076 22 . . . cord-010119-t1x9gknd 9077 1 In in IN cord-010119-t1x9gknd 9077 2 our -PRON- PRP$ cord-010119-t1x9gknd 9077 3 data datum NNS cord-010119-t1x9gknd 9077 4 validating validate VBG cord-010119-t1x9gknd 9077 5 PAS pas NN cord-010119-t1x9gknd 9077 6 and and CC cord-010119-t1x9gknd 9077 7 PR PR NNP cord-010119-t1x9gknd 9077 8 , , , cord-010119-t1x9gknd 9077 9 the the DT cord-010119-t1x9gknd 9077 10 post post NN cord-010119-t1x9gknd 9077 11 counts count VBZ cord-010119-t1x9gknd 9077 12 from from IN cord-010119-t1x9gknd 9077 13 transfusion transfusion NN cord-010119-t1x9gknd 9077 14 of of IN cord-010119-t1x9gknd 9077 15 PAS pas NN cord-010119-t1x9gknd 9077 16 - - HYPH cord-010119-t1x9gknd 9077 17 C C NNP cord-010119-t1x9gknd 9077 18 and and CC cord-010119-t1x9gknd 9077 19 PR PR NNP cord-010119-t1x9gknd 9077 20 products product NNS cord-010119-t1x9gknd 9077 21 have have VBP cord-010119-t1x9gknd 9077 22 been be VBN cord-010119-t1x9gknd 9077 23 statistically statistically RB cord-010119-t1x9gknd 9077 24 lower low JJR cord-010119-t1x9gknd 9077 25 than than IN cord-010119-t1x9gknd 9077 26 platelets platelet NNS cord-010119-t1x9gknd 9077 27 in in IN cord-010119-t1x9gknd 9077 28 all all DT cord-010119-t1x9gknd 9077 29 plasma plasma NN cord-010119-t1x9gknd 9077 30 ( ( -LRB- cord-010119-t1x9gknd 9077 31 PP PP NNP cord-010119-t1x9gknd 9077 32 ) ) -RRB- cord-010119-t1x9gknd 9077 33 or or CC cord-010119-t1x9gknd 9077 34 PAS PAS NNP cord-010119-t1x9gknd 9077 35 F F NNP cord-010119-t1x9gknd 9077 36 products product NNS cord-010119-t1x9gknd 9077 37 . . . cord-010119-t1x9gknd 9078 1 Our -PRON- PRP$ cord-010119-t1x9gknd 9078 2 study study NN cord-010119-t1x9gknd 9078 3 looks look VBZ cord-010119-t1x9gknd 9078 4 at at IN cord-010119-t1x9gknd 9078 5 whether whether IN cord-010119-t1x9gknd 9078 6 this this DT cord-010119-t1x9gknd 9078 7 difference difference NN cord-010119-t1x9gknd 9078 8 has have VBZ cord-010119-t1x9gknd 9078 9 led lead VBN cord-010119-t1x9gknd 9078 10 to to IN cord-010119-t1x9gknd 9078 11 a a DT cord-010119-t1x9gknd 9078 12 corresponding corresponding JJ cord-010119-t1x9gknd 9078 13 increase increase NN cord-010119-t1x9gknd 9078 14 in in IN cord-010119-t1x9gknd 9078 15 the the DT cord-010119-t1x9gknd 9078 16 number number NN cord-010119-t1x9gknd 9078 17 of of IN cord-010119-t1x9gknd 9078 18 units unit NNS cord-010119-t1x9gknd 9078 19 of of IN cord-010119-t1x9gknd 9078 20 platelets platelet NNS cord-010119-t1x9gknd 9078 21 transfused transfuse VBN cord-010119-t1x9gknd 9078 22 . . . cord-010119-t1x9gknd 9079 1 Study Study NNP cord-010119-t1x9gknd 9079 2 Design Design NNP cord-010119-t1x9gknd 9079 3 / / SYM cord-010119-t1x9gknd 9079 4 Method method NN cord-010119-t1x9gknd 9079 5 : : : cord-010119-t1x9gknd 9080 1 The the DT cord-010119-t1x9gknd 9080 2 data datum NNS cord-010119-t1x9gknd 9080 3 was be VBD cord-010119-t1x9gknd 9080 4 obtained obtain VBN cord-010119-t1x9gknd 9080 5 from from IN cord-010119-t1x9gknd 9080 6 the the DT cord-010119-t1x9gknd 9080 7 routine routine JJ cord-010119-t1x9gknd 9080 8 quality quality NN cord-010119-t1x9gknd 9080 9 reports report NNS cord-010119-t1x9gknd 9080 10 produced produce VBN cord-010119-t1x9gknd 9080 11 for for IN cord-010119-t1x9gknd 9080 12 the the DT cord-010119-t1x9gknd 9080 13 blood blood NN cord-010119-t1x9gknd 9080 14 utilization utilization NN cord-010119-t1x9gknd 9080 15 committee committee NN cord-010119-t1x9gknd 9080 16 at at IN cord-010119-t1x9gknd 9080 17 our -PRON- PRP$ cord-010119-t1x9gknd 9080 18 facility facility NN cord-010119-t1x9gknd 9080 19 between between IN cord-010119-t1x9gknd 9080 20 2012 2012 CD cord-010119-t1x9gknd 9080 21 and and CC cord-010119-t1x9gknd 9080 22 2016 2016 CD cord-010119-t1x9gknd 9080 23 . . . cord-010119-t1x9gknd 9081 1 During during IN cord-010119-t1x9gknd 9081 2 this this DT cord-010119-t1x9gknd 9081 3 time time NN cord-010119-t1x9gknd 9081 4 PAS pas NN cord-010119-t1x9gknd 9081 5 C c NN cord-010119-t1x9gknd 9081 6 , , , cord-010119-t1x9gknd 9081 7 PAS PAS NNP cord-010119-t1x9gknd 9081 8 F F NNP cord-010119-t1x9gknd 9081 9 and and CC cord-010119-t1x9gknd 9081 10 PR PR NNP cord-010119-t1x9gknd 9081 11 went go VBD cord-010119-t1x9gknd 9081 12 from from IN cord-010119-t1x9gknd 9081 13 13 13 CD cord-010119-t1x9gknd 9081 14 % % NN cord-010119-t1x9gknd 9081 15 to to IN cord-010119-t1x9gknd 9081 16 40 40 CD cord-010119-t1x9gknd 9081 17 % % NN cord-010119-t1x9gknd 9081 18 of of IN cord-010119-t1x9gknd 9081 19 all all DT cord-010119-t1x9gknd 9081 20 platelet platelet NN cord-010119-t1x9gknd 9081 21 products product NNS cord-010119-t1x9gknd 9081 22 given give VBN cord-010119-t1x9gknd 9081 23 . . . cord-010119-t1x9gknd 9082 1 All all DT cord-010119-t1x9gknd 9082 2 recipients recipient NNS cord-010119-t1x9gknd 9082 3 had have VBD cord-010119-t1x9gknd 9082 4 an an DT cord-010119-t1x9gknd 9082 5 oncology oncology NN cord-010119-t1x9gknd 9082 6 diagnosis diagnosis NN cord-010119-t1x9gknd 9082 7 . . . cord-010119-t1x9gknd 9083 1 The the DT cord-010119-t1x9gknd 9083 2 data datum NNS cord-010119-t1x9gknd 9083 3 collected collect VBD cord-010119-t1x9gknd 9083 4 included include VBD cord-010119-t1x9gknd 9083 5 the the DT cord-010119-t1x9gknd 9083 6 service service NN cord-010119-t1x9gknd 9083 7 , , , cord-010119-t1x9gknd 9083 8 unit unit NN cord-010119-t1x9gknd 9083 9 number number NN cord-010119-t1x9gknd 9083 10 and and CC cord-010119-t1x9gknd 9083 11 product product NN cord-010119-t1x9gknd 9083 12 code code NN cord-010119-t1x9gknd 9083 13 . . . cord-010119-t1x9gknd 9084 1 The the DT cord-010119-t1x9gknd 9084 2 number number NN cord-010119-t1x9gknd 9084 3 of of IN cord-010119-t1x9gknd 9084 4 unique unique JJ cord-010119-t1x9gknd 9084 5 recipients recipient NNS cord-010119-t1x9gknd 9084 6 was be VBD cord-010119-t1x9gknd 9084 7 determined determine VBN cord-010119-t1x9gknd 9084 8 monthly monthly RB cord-010119-t1x9gknd 9084 9 . . . cord-010119-t1x9gknd 9085 1 The the DT cord-010119-t1x9gknd 9085 2 data datum NNS cord-010119-t1x9gknd 9085 3 was be VBD cord-010119-t1x9gknd 9085 4 converted convert VBN cord-010119-t1x9gknd 9085 5 to to IN cord-010119-t1x9gknd 9085 6 PLT PLT NNP cord-010119-t1x9gknd 9085 7 / / SYM cord-010119-t1x9gknd 9085 8 month month NN cord-010119-t1x9gknd 9085 9 / / SYM cord-010119-t1x9gknd 9085 10 recipient recipient NN cord-010119-t1x9gknd 9085 11 for for IN cord-010119-t1x9gknd 9085 12 analysis analysis NN cord-010119-t1x9gknd 9085 13 . . . cord-010119-t1x9gknd 9086 1 Statistical statistical JJ cord-010119-t1x9gknd 9086 2 analysis analysis NN cord-010119-t1x9gknd 9086 3 was be VBD cord-010119-t1x9gknd 9086 4 performed perform VBN cord-010119-t1x9gknd 9086 5 using use VBG cord-010119-t1x9gknd 9086 6 the the DT cord-010119-t1x9gknd 9086 7 two two CD cord-010119-t1x9gknd 9086 8 sample sample NN cord-010119-t1x9gknd 9086 9 T t NN cord-010119-t1x9gknd 9086 10 - - HYPH cord-010119-t1x9gknd 9086 11 test test NN cord-010119-t1x9gknd 9086 12 Results result NNS cord-010119-t1x9gknd 9086 13 / / SYM cord-010119-t1x9gknd 9086 14 Finding finding NN cord-010119-t1x9gknd 9086 15 : : : cord-010119-t1x9gknd 9087 1 The the DT cord-010119-t1x9gknd 9087 2 data datum NNS cord-010119-t1x9gknd 9087 3 was be VBD cord-010119-t1x9gknd 9087 4 normalized normalize VBN cord-010119-t1x9gknd 9087 5 to to IN cord-010119-t1x9gknd 9087 6 PLT PLT NNP cord-010119-t1x9gknd 9087 7 / / SYM cord-010119-t1x9gknd 9087 8 recipient recipient NN cord-010119-t1x9gknd 9087 9 / / SYM cord-010119-t1x9gknd 9087 10 month month NN cord-010119-t1x9gknd 9087 11 . . . cord-010119-t1x9gknd 9088 1 In in IN cord-010119-t1x9gknd 9088 2 2011 2011 CD cord-010119-t1x9gknd 9088 3 patients patient NNS cord-010119-t1x9gknd 9088 4 received receive VBD cord-010119-t1x9gknd 9088 5 an an DT cord-010119-t1x9gknd 9088 6 average average NN cord-010119-t1x9gknd 9088 7 of of IN cord-010119-t1x9gknd 9088 8 5.41 5.41 CD cord-010119-t1x9gknd 9088 9 units unit NNS cord-010119-t1x9gknd 9088 10 / / SYM cord-010119-t1x9gknd 9088 11 recipient recipient NN cord-010119-t1x9gknd 9088 12 / / SYM cord-010119-t1x9gknd 9088 13 month month NN cord-010119-t1x9gknd 9088 14 and and CC cord-010119-t1x9gknd 9088 15 in in IN cord-010119-t1x9gknd 9088 16 2016 2016 CD cord-010119-t1x9gknd 9088 17 the the DT cord-010119-t1x9gknd 9088 18 average average NN cord-010119-t1x9gknd 9088 19 was be VBD cord-010119-t1x9gknd 9088 20 5.39 5.39 CD cord-010119-t1x9gknd 9088 21 units unit NNS cord-010119-t1x9gknd 9088 22 / / SYM cord-010119-t1x9gknd 9088 23 recipient recipient NN cord-010119-t1x9gknd 9088 24 / / SYM cord-010119-t1x9gknd 9088 25 month month NN cord-010119-t1x9gknd 9088 26 . . . cord-010119-t1x9gknd 9089 1 The the DT cord-010119-t1x9gknd 9089 2 intervening intervene VBG cord-010119-t1x9gknd 9089 3 data data NN cord-010119-t1x9gknd 9089 4 points point NNS cord-010119-t1x9gknd 9089 5 for for IN cord-010119-t1x9gknd 9089 6 2013 2013 CD cord-010119-t1x9gknd 9089 7 , , , cord-010119-t1x9gknd 9089 8 2014 2014 CD cord-010119-t1x9gknd 9089 9 , , , cord-010119-t1x9gknd 9089 10 and and CC cord-010119-t1x9gknd 9089 11 2015 2015 CD cord-010119-t1x9gknd 9089 12 were be VBD cord-010119-t1x9gknd 9089 13 5.92 5.92 CD cord-010119-t1x9gknd 9089 14 , , , cord-010119-t1x9gknd 9089 15 5.66 5.66 CD cord-010119-t1x9gknd 9089 16 , , , cord-010119-t1x9gknd 9089 17 and and CC cord-010119-t1x9gknd 9089 18 5.92 5.92 CD cord-010119-t1x9gknd 9089 19 respectively respectively RB cord-010119-t1x9gknd 9089 20 . . . cord-010119-t1x9gknd 9090 1 The the DT cord-010119-t1x9gknd 9090 2 5 5 CD cord-010119-t1x9gknd 9090 3 year year NN cord-010119-t1x9gknd 9090 4 average average NN cord-010119-t1x9gknd 9090 5 was be VBD cord-010119-t1x9gknd 9090 6 5.66 5.66 CD cord-010119-t1x9gknd 9090 7 . . . cord-010119-t1x9gknd 9091 1 The the DT cord-010119-t1x9gknd 9091 2 slope slope NN cord-010119-t1x9gknd 9091 3 of of IN cord-010119-t1x9gknd 9091 4 the the DT cord-010119-t1x9gknd 9091 5 graph graph NN cord-010119-t1x9gknd 9091 6 for for IN cord-010119-t1x9gknd 9091 7 all all DT cord-010119-t1x9gknd 9091 8 5 5 CD cord-010119-t1x9gknd 9091 9 points point NNS cord-010119-t1x9gknd 9091 10 was be VBD cord-010119-t1x9gknd 9091 11 y5 y5 NNP cord-010119-t1x9gknd 9091 12 -0.004 -0.004 NNP cord-010119-t1x9gknd 9091 13 15.672 15.672 CD cord-010119-t1x9gknd 9091 14 . . . cord-010119-t1x9gknd 9092 1 The the DT cord-010119-t1x9gknd 9092 2 two two CD cord-010119-t1x9gknd 9092 3 sample sample NN cord-010119-t1x9gknd 9092 4 T t NN cord-010119-t1x9gknd 9092 5 - - HYPH cord-010119-t1x9gknd 9092 6 test test NN cord-010119-t1x9gknd 9092 7 showed show VBD cord-010119-t1x9gknd 9092 8 that that IN cord-010119-t1x9gknd 9092 9 the the DT cord-010119-t1x9gknd 9092 10 PLT PLT NNP cord-010119-t1x9gknd 9092 11 / / SYM cord-010119-t1x9gknd 9092 12 recipient recipient NN cord-010119-t1x9gknd 9092 13 / / SYM cord-010119-t1x9gknd 9092 14 month month NN cord-010119-t1x9gknd 9092 15 from from IN cord-010119-t1x9gknd 9092 16 2012 2012 CD cord-010119-t1x9gknd 9092 17 to to IN cord-010119-t1x9gknd 9092 18 2016 2016 CD cord-010119-t1x9gknd 9092 19 was be VBD cord-010119-t1x9gknd 9092 20 not not RB cord-010119-t1x9gknd 9092 21 statistically statistically RB cord-010119-t1x9gknd 9092 22 different different JJ cord-010119-t1x9gknd 9092 23 with with IN cord-010119-t1x9gknd 9092 24 a a DT cord-010119-t1x9gknd 9092 25 P p NN cord-010119-t1x9gknd 9092 26 value value NN cord-010119-t1x9gknd 9092 27 of of IN cord-010119-t1x9gknd 9092 28 0.81 0.81 CD cord-010119-t1x9gknd 9092 29 . . . cord-010119-t1x9gknd 9093 1 Conclusion conclusion NN cord-010119-t1x9gknd 9093 2 : : : cord-010119-t1x9gknd 9094 1 The the DT cord-010119-t1x9gknd 9094 2 implementation implementation NN cord-010119-t1x9gknd 9094 3 of of IN cord-010119-t1x9gknd 9094 4 PAS pas NN cord-010119-t1x9gknd 9094 5 and and CC cord-010119-t1x9gknd 9094 6 PR PR NNP cord-010119-t1x9gknd 9094 7 platelets platelet NNS cord-010119-t1x9gknd 9094 8 in in IN cord-010119-t1x9gknd 9094 9 the the DT cord-010119-t1x9gknd 9094 10 oncology oncology NN cord-010119-t1x9gknd 9094 11 environment environment NN cord-010119-t1x9gknd 9094 12 has have VBZ cord-010119-t1x9gknd 9094 13 not not RB cord-010119-t1x9gknd 9094 14 increased increase VBN cord-010119-t1x9gknd 9094 15 in in IN cord-010119-t1x9gknd 9094 16 the the DT cord-010119-t1x9gknd 9094 17 number number NN cord-010119-t1x9gknd 9094 18 of of IN cord-010119-t1x9gknd 9094 19 platelet platelet NN cord-010119-t1x9gknd 9094 20 transfusions transfusion NNS cord-010119-t1x9gknd 9094 21 given give VBN cord-010119-t1x9gknd 9094 22 . . . cord-010119-t1x9gknd 9095 1 In in IN cord-010119-t1x9gknd 9095 2 additional additional JJ cord-010119-t1x9gknd 9095 3 analysis analysis NN cord-010119-t1x9gknd 9095 4 , , , cord-010119-t1x9gknd 9095 5 the the DT cord-010119-t1x9gknd 9095 6 red red JJ cord-010119-t1x9gknd 9095 7 cell cell NN cord-010119-t1x9gknd 9095 8 use use NN cord-010119-t1x9gknd 9095 9 has have VBZ cord-010119-t1x9gknd 9095 10 decreased decrease VBN cord-010119-t1x9gknd 9095 11 ( ( -LRB- cord-010119-t1x9gknd 9095 12 data datum NNS cord-010119-t1x9gknd 9095 13 not not RB cord-010119-t1x9gknd 9095 14 shown show VBN cord-010119-t1x9gknd 9095 15 ) ) -RRB- cord-010119-t1x9gknd 9095 16 . . . cord-010119-t1x9gknd 9096 1 This this DT cord-010119-t1x9gknd 9096 2 can can MD cord-010119-t1x9gknd 9096 3 be be VB cord-010119-t1x9gknd 9096 4 interpreted interpret VBN cord-010119-t1x9gknd 9096 5 as as IN cord-010119-t1x9gknd 9096 6 indicating indicate VBG cord-010119-t1x9gknd 9096 7 that that IN cord-010119-t1x9gknd 9096 8 patients patient NNS cord-010119-t1x9gknd 9096 9 have have VBP cord-010119-t1x9gknd 9096 10 not not RB cord-010119-t1x9gknd 9096 11 had have VBN cord-010119-t1x9gknd 9096 12 increased increase VBN cord-010119-t1x9gknd 9096 13 episodes episode NNS cord-010119-t1x9gknd 9096 14 of of IN cord-010119-t1x9gknd 9096 15 bleeding bleed VBG cord-010119-t1x9gknd 9096 16 . . . cord-010119-t1x9gknd 9097 1 Although although IN cord-010119-t1x9gknd 9097 2 the the DT cord-010119-t1x9gknd 9097 3 post post NN cord-010119-t1x9gknd 9097 4 platelet platelet NN cord-010119-t1x9gknd 9097 5 count count NN cord-010119-t1x9gknd 9097 6 from from IN cord-010119-t1x9gknd 9097 7 PAS pas NN cord-010119-t1x9gknd 9097 8 / / SYM cord-010119-t1x9gknd 9097 9 PR PR NNP cord-010119-t1x9gknd 9097 10 platelets platelet NNS cord-010119-t1x9gknd 9097 11 may may MD cord-010119-t1x9gknd 9097 12 be be VB cord-010119-t1x9gknd 9097 13 lower low JJR cord-010119-t1x9gknd 9097 14 , , , cord-010119-t1x9gknd 9097 15 we -PRON- PRP cord-010119-t1x9gknd 9097 16 do do VBP cord-010119-t1x9gknd 9097 17 not not RB cord-010119-t1x9gknd 9097 18 have have VB cord-010119-t1x9gknd 9097 19 evidence evidence NN cord-010119-t1x9gknd 9097 20 from from IN cord-010119-t1x9gknd 9097 21 our -PRON- PRP$ cord-010119-t1x9gknd 9097 22 platelet platelet NN cord-010119-t1x9gknd 9097 23 transfusion transfusion NN cord-010119-t1x9gknd 9097 24 data datum NNS cord-010119-t1x9gknd 9097 25 that that IN cord-010119-t1x9gknd 9097 26 this this DT cord-010119-t1x9gknd 9097 27 is be VBZ cord-010119-t1x9gknd 9097 28 leading lead VBG cord-010119-t1x9gknd 9097 29 to to IN cord-010119-t1x9gknd 9097 30 clinical clinical JJ cord-010119-t1x9gknd 9097 31 outcomes outcome NNS cord-010119-t1x9gknd 9097 32 necessitating necessitate VBG cord-010119-t1x9gknd 9097 33 additional additional JJ cord-010119-t1x9gknd 9097 34 products product NNS cord-010119-t1x9gknd 9097 35 to to TO cord-010119-t1x9gknd 9097 36 be be VB cord-010119-t1x9gknd 9097 37 given give VBN cord-010119-t1x9gknd 9097 38 . . . cord-010119-t1x9gknd 9098 1 Background Background NNP cord-010119-t1x9gknd 9098 2 / / SYM cord-010119-t1x9gknd 9098 3 Case Case NNP cord-010119-t1x9gknd 9098 4 Studies Studies NNPS cord-010119-t1x9gknd 9099 1 : : : cord-010119-t1x9gknd 9099 2 It -PRON- PRP cord-010119-t1x9gknd 9099 3 is be VBZ cord-010119-t1x9gknd 9099 4 reported report VBN cord-010119-t1x9gknd 9099 5 that that IN cord-010119-t1x9gknd 9099 6 the the DT cord-010119-t1x9gknd 9099 7 incidence incidence NN cord-010119-t1x9gknd 9099 8 of of IN cord-010119-t1x9gknd 9099 9 alloimmunization alloimmunization NN cord-010119-t1x9gknd 9099 10 in in IN cord-010119-t1x9gknd 9099 11 AML AML NNP cord-010119-t1x9gknd 9099 12 patients patient NNS cord-010119-t1x9gknd 9099 13 is be VBZ cord-010119-t1x9gknd 9099 14 unrelated unrelated JJ cord-010119-t1x9gknd 9099 15 to to IN cord-010119-t1x9gknd 9099 16 the the DT cord-010119-t1x9gknd 9099 17 number number NN cord-010119-t1x9gknd 9099 18 of of IN cord-010119-t1x9gknd 9099 19 transfusions transfusion NNS cord-010119-t1x9gknd 9099 20 the the DT cord-010119-t1x9gknd 9099 21 patient patient NN cord-010119-t1x9gknd 9099 22 receives receive VBZ cord-010119-t1x9gknd 9099 23 and and CC cord-010119-t1x9gknd 9099 24 most most JJS cord-010119-t1x9gknd 9099 25 patients patient NNS cord-010119-t1x9gknd 9099 26 who who WP cord-010119-t1x9gknd 9099 27 have have VBP cord-010119-t1x9gknd 9099 28 HLA HLA NNP cord-010119-t1x9gknd 9099 29 antibodies antibody NNS cord-010119-t1x9gknd 9099 30 do do VBP cord-010119-t1x9gknd 9099 31 not not RB cord-010119-t1x9gknd 9099 32 exhibit exhibit VB cord-010119-t1x9gknd 9099 33 platelet platelet NN cord-010119-t1x9gknd 9099 34 refractoriness refractoriness NN cord-010119-t1x9gknd 9099 35 . . . cord-010119-t1x9gknd 9100 1 Many many JJ cord-010119-t1x9gknd 9100 2 cases case NNS cord-010119-t1x9gknd 9100 3 are be VBP cord-010119-t1x9gknd 9100 4 also also RB cord-010119-t1x9gknd 9100 5 found find VBN cord-010119-t1x9gknd 9100 6 not not RB cord-010119-t1x9gknd 9100 7 to to TO cord-010119-t1x9gknd 9100 8 have have VB cord-010119-t1x9gknd 9100 9 any any DT cord-010119-t1x9gknd 9100 10 anti anti JJ cord-010119-t1x9gknd 9100 11 - - JJ cord-010119-t1x9gknd 9100 12 platelet platelet JJ cord-010119-t1x9gknd 9100 13 antibodies antibody NNS cord-010119-t1x9gknd 9100 14 detectable detectable JJ cord-010119-t1x9gknd 9100 15 by by IN cord-010119-t1x9gknd 9100 16 standard standard JJ cord-010119-t1x9gknd 9100 17 laboratory laboratory NN cord-010119-t1x9gknd 9100 18 tests test NNS cord-010119-t1x9gknd 9100 19 . . . cord-010119-t1x9gknd 9101 1 Recent recent JJ cord-010119-t1x9gknd 9101 2 data datum NNS cord-010119-t1x9gknd 9101 3 in in IN cord-010119-t1x9gknd 9101 4 leukemia leukemia NN cord-010119-t1x9gknd 9101 5 and and CC cord-010119-t1x9gknd 9101 6 hematopoietic hematopoietic JJ cord-010119-t1x9gknd 9101 7 stem stem NN cord-010119-t1x9gknd 9101 8 cell cell NN cord-010119-t1x9gknd 9101 9 ( ( -LRB- cord-010119-t1x9gknd 9101 10 HSCT HSCT NNP cord-010119-t1x9gknd 9101 11 ) ) -RRB- cord-010119-t1x9gknd 9101 12 recipients recipient NNS cord-010119-t1x9gknd 9101 13 transfused transfuse VBN cord-010119-t1x9gknd 9101 14 exclusively exclusively RB cord-010119-t1x9gknd 9101 15 with with IN cord-010119-t1x9gknd 9101 16 leukoreduced leukoreduced JJ cord-010119-t1x9gknd 9101 17 products product NNS cord-010119-t1x9gknd 9101 18 show show VBP cord-010119-t1x9gknd 9101 19 that that IN cord-010119-t1x9gknd 9101 20 4 4 CD cord-010119-t1x9gknd 9101 21 % % NN cord-010119-t1x9gknd 9101 22 to to TO cord-010119-t1x9gknd 9101 23 8 8 CD cord-010119-t1x9gknd 9101 24 % % NN cord-010119-t1x9gknd 9101 25 develop develop VB cord-010119-t1x9gknd 9101 26 Alloimmune Alloimmune NNP cord-010119-t1x9gknd 9101 27 platelet platelet NN cord-010119-t1x9gknd 9101 28 refractoriness refractoriness NN cord-010119-t1x9gknd 9101 29 . . . cord-010119-t1x9gknd 9102 1 Objective objective NN cord-010119-t1x9gknd 9102 2 : : : cord-010119-t1x9gknd 9102 3 To to TO cord-010119-t1x9gknd 9102 4 determine determine VB cord-010119-t1x9gknd 9102 5 an an DT cord-010119-t1x9gknd 9102 6 improvement improvement NN cord-010119-t1x9gknd 9102 7 in in IN cord-010119-t1x9gknd 9102 8 platelet platelet NN cord-010119-t1x9gknd 9102 9 count count NN cord-010119-t1x9gknd 9102 10 with with IN cord-010119-t1x9gknd 9102 11 the the DT cord-010119-t1x9gknd 9102 12 match match NN cord-010119-t1x9gknd 9102 13 grade grade NN cord-010119-t1x9gknd 9102 14 and/or and/or CC cord-010119-t1x9gknd 9102 15 the the DT cord-010119-t1x9gknd 9102 16 ABO ABO NNP cord-010119-t1x9gknd 9102 17 blood blood NN cord-010119-t1x9gknd 9102 18 group group NN cord-010119-t1x9gknd 9102 19 of of IN cord-010119-t1x9gknd 9102 20 the the DT cord-010119-t1x9gknd 9102 21 HLA HLA NNP cord-010119-t1x9gknd 9102 22 matched match VBN cord-010119-t1x9gknd 9102 23 platelets platelet NNS cord-010119-t1x9gknd 9102 24 in in IN cord-010119-t1x9gknd 9102 25 highly highly RB cord-010119-t1x9gknd 9102 26 alloimmunized alloimmunize VBN cord-010119-t1x9gknd 9102 27 patients patient NNS cord-010119-t1x9gknd 9102 28 with with IN cord-010119-t1x9gknd 9102 29 concomitant concomitant JJ cord-010119-t1x9gknd 9102 30 non non JJ cord-010119-t1x9gknd 9102 31 - - JJ cord-010119-t1x9gknd 9102 32 immune immune JJ cord-010119-t1x9gknd 9102 33 causes cause NNS cord-010119-t1x9gknd 9102 34 for for IN cord-010119-t1x9gknd 9102 35 platelet platelet NN cord-010119-t1x9gknd 9102 36 destruction destruction NN cord-010119-t1x9gknd 9102 37 . . . cord-010119-t1x9gknd 9103 1 Study Study NNP cord-010119-t1x9gknd 9103 2 Design Design NNP cord-010119-t1x9gknd 9103 3 / / SYM cord-010119-t1x9gknd 9103 4 Method method NN cord-010119-t1x9gknd 9103 5 : : : cord-010119-t1x9gknd 9103 6 Clinically clinically RB cord-010119-t1x9gknd 9103 7 documented document VBN cord-010119-t1x9gknd 9103 8 platelet platelet NN cord-010119-t1x9gknd 9103 9 refractory refractory JJ cord-010119-t1x9gknd 9103 10 patients patient NNS cord-010119-t1x9gknd 9103 11 , , , cord-010119-t1x9gknd 9103 12 who who WP cord-010119-t1x9gknd 9103 13 received receive VBD cord-010119-t1x9gknd 9103 14 HLA HLA NNP cord-010119-t1x9gknd 9103 15 matched match VBN cord-010119-t1x9gknd 9103 16 irradiated irradiate VBN cord-010119-t1x9gknd 9103 17 SDA SDA NNP cord-010119-t1x9gknd 9103 18 platelets platelet NNS cord-010119-t1x9gknd 9103 19 with with IN cord-010119-t1x9gknd 9103 20 their -PRON- PRP$ cord-010119-t1x9gknd 9103 21 HLA HLA NNP cord-010119-t1x9gknd 9103 22 typings typing NNS cord-010119-t1x9gknd 9103 23 for for IN cord-010119-t1x9gknd 9103 24 HLA HLA NNP cord-010119-t1x9gknd 9103 25 - - HYPH cord-010119-t1x9gknd 9103 26 A/-B A/-B NNP cord-010119-t1x9gknd 9103 27 and and CC cord-010119-t1x9gknd 9103 28 HLA HLA NNP cord-010119-t1x9gknd 9103 29 Antibody Antibody NNP cord-010119-t1x9gknd 9103 30 Identification Identification NNP cord-010119-t1x9gknd 9103 31 were be VBD cord-010119-t1x9gknd 9103 32 reviewed review VBN cord-010119-t1x9gknd 9103 33 . . . cord-010119-t1x9gknd 9104 1 There there EX cord-010119-t1x9gknd 9104 2 were be VBD cord-010119-t1x9gknd 9104 3 two two CD cord-010119-t1x9gknd 9104 4 strategies strategy NNS cord-010119-t1x9gknd 9104 5 utilized utilize VBN cord-010119-t1x9gknd 9104 6 , , , cord-010119-t1x9gknd 9104 7 the the DT cord-010119-t1x9gknd 9104 8 HLA HLA NNP cord-010119-t1x9gknd 9104 9 strategy strategy NN cord-010119-t1x9gknd 9104 10 ( ( -LRB- cord-010119-t1x9gknd 9104 11 matching match VBG cord-010119-t1x9gknd 9104 12 recipient recipient NN cord-010119-t1x9gknd 9104 13 and and CC cord-010119-t1x9gknd 9104 14 donor donor NN cord-010119-t1x9gknd 9104 15 HLA HLA NNP cord-010119-t1x9gknd 9104 16 - - HYPH cord-010119-t1x9gknd 9104 17 A/ A/ NNP cord-010119-t1x9gknd 9104 18 -B -b ADD cord-010119-t1x9gknd 9104 19 types type NNS cord-010119-t1x9gknd 9104 20 ) ) -RRB- cord-010119-t1x9gknd 9104 21 and and CC cord-010119-t1x9gknd 9104 22 the the DT cord-010119-t1x9gknd 9104 23 antibody antibody NN cord-010119-t1x9gknd 9104 24 specificity specificity NN cord-010119-t1x9gknd 9104 25 prediction prediction NN cord-010119-t1x9gknd 9104 26 ( ( -LRB- cord-010119-t1x9gknd 9104 27 patient patient NN cord-010119-t1x9gknd 9104 28 provided provide VBN cord-010119-t1x9gknd 9104 29 with with IN cord-010119-t1x9gknd 9104 30 platelets platelet NNS cord-010119-t1x9gknd 9104 31 from from IN cord-010119-t1x9gknd 9104 32 donors donor NNS cord-010119-t1x9gknd 9104 33 lacking lack VBG cord-010119-t1x9gknd 9104 34 only only RB cord-010119-t1x9gknd 9104 35 those those DT cord-010119-t1x9gknd 9104 36 HLAs hla NNS cord-010119-t1x9gknd 9104 37 to to TO cord-010119-t1x9gknd 9104 38 which which WDT cord-010119-t1x9gknd 9104 39 the the DT cord-010119-t1x9gknd 9104 40 patient patient NN cord-010119-t1x9gknd 9104 41 had have VBD cord-010119-t1x9gknd 9104 42 antibodies antibody NNS cord-010119-t1x9gknd 9104 43 ) ) -RRB- cord-010119-t1x9gknd 9104 44 strategy strategy NN cord-010119-t1x9gknd 9104 45 . . . cord-010119-t1x9gknd 9105 1 Statistical Statistical NNP cord-010119-t1x9gknd 9105 2 Analysis Analysis NNP cord-010119-t1x9gknd 9105 3 : : : cord-010119-t1x9gknd 9106 1 A a DT cord-010119-t1x9gknd 9106 2 One one CD cord-010119-t1x9gknd 9106 3 Sample Sample NNP cord-010119-t1x9gknd 9106 4 t t NN cord-010119-t1x9gknd 9106 5 - - HYPH cord-010119-t1x9gknd 9106 6 test test NN cord-010119-t1x9gknd 9106 7 using use VBG cord-010119-t1x9gknd 9106 8 Minitab Minitab NNP cord-010119-t1x9gknd 9106 9 17 17 CD cord-010119-t1x9gknd 9106 10 Statistical statistical JJ cord-010119-t1x9gknd 9106 11 software software NN cord-010119-t1x9gknd 9106 12 was be VBD cord-010119-t1x9gknd 9106 13 performed perform VBN cord-010119-t1x9gknd 9106 14 comparing compare VBG cord-010119-t1x9gknd 9106 15 the the DT cord-010119-t1x9gknd 9106 16 mean mean NN cord-010119-t1x9gknd 9106 17 against against IN cord-010119-t1x9gknd 9106 18 a a DT cord-010119-t1x9gknd 9106 19 platelet platelet NN cord-010119-t1x9gknd 9106 20 increment increment NN cord-010119-t1x9gknd 9106 21 of of IN cord-010119-t1x9gknd 9106 22 a a DT cord-010119-t1x9gknd 9106 23 hypothetical hypothetical JJ cord-010119-t1x9gknd 9106 24 difference difference NN cord-010119-t1x9gknd 9106 25 of of IN cord-010119-t1x9gknd 9106 26 at at RB cord-010119-t1x9gknd 9106 27 least least JJS cord-010119-t1x9gknd 9106 28 5 5 CD cord-010119-t1x9gknd 9106 29 K K NNP cord-010119-t1x9gknd 9106 30 / / SYM cord-010119-t1x9gknd 9106 31 ul ul NN cord-010119-t1x9gknd 9106 32 . . . cord-010119-t1x9gknd 9107 1 The the DT cord-010119-t1x9gknd 9107 2 analysis analysis NN cord-010119-t1x9gknd 9107 3 revealed reveal VBD cord-010119-t1x9gknd 9107 4 that that IN cord-010119-t1x9gknd 9107 5 the the DT cord-010119-t1x9gknd 9107 6 mean mean NN cord-010119-t1x9gknd 9107 7 of of IN cord-010119-t1x9gknd 9107 8 9.35 9.35 CD cord-010119-t1x9gknd 9107 9 K K NNP cord-010119-t1x9gknd 9107 10 / / SYM cord-010119-t1x9gknd 9107 11 ul ul NN cord-010119-t1x9gknd 9107 12 ( ( -LRB- cord-010119-t1x9gknd 9107 13 n584 n584 NNP cord-010119-t1x9gknd 9107 14 ) ) -RRB- cord-010119-t1x9gknd 9107 15 had have VBD cord-010119-t1x9gknd 9107 16 a a DT cord-010119-t1x9gknd 9107 17 95 95 CD cord-010119-t1x9gknd 9107 18 percent percent NN cord-010119-t1x9gknd 9107 19 lower low JJR cord-010119-t1x9gknd 9107 20 bound bind VBN cord-010119-t1x9gknd 9107 21 confidence confidence NN cord-010119-t1x9gknd 9107 22 interval interval NN cord-010119-t1x9gknd 9107 23 platelet platelet NN cord-010119-t1x9gknd 9107 24 increment increment NN cord-010119-t1x9gknd 9107 25 of of IN cord-010119-t1x9gknd 9107 26 7 7 CD cord-010119-t1x9gknd 9107 27 K K NNP cord-010119-t1x9gknd 9107 28 / / SYM cord-010119-t1x9gknd 9107 29 ul ul NN cord-010119-t1x9gknd 9107 30 ( ( -LRB- cord-010119-t1x9gknd 9107 31 p<50.001 p<50.001 NNP cord-010119-t1x9gknd 9107 32 ) ) -RRB- cord-010119-t1x9gknd 9108 1 Results result NNS cord-010119-t1x9gknd 9108 2 / / SYM cord-010119-t1x9gknd 9108 3 Findings finding NNS cord-010119-t1x9gknd 9108 4 : : : cord-010119-t1x9gknd 9108 5 123 123 CD cord-010119-t1x9gknd 9108 6 ( ( -LRB- cord-010119-t1x9gknd 9108 7 median median NN cord-010119-t1x9gknd 9108 8 4 4 CD cord-010119-t1x9gknd 9108 9 range range NN cord-010119-t1x9gknd 9108 10 [ [ -LRB- cord-010119-t1x9gknd 9108 11 1 1 CD cord-010119-t1x9gknd 9108 12 - - SYM cord-010119-t1x9gknd 9108 13 43 43 CD cord-010119-t1x9gknd 9108 14 ] ] -RRB- cord-010119-t1x9gknd 9108 15 ) ) -RRB- cord-010119-t1x9gknd 9109 1 HLA HLA NNP cord-010119-t1x9gknd 9109 2 matched match VBD cord-010119-t1x9gknd 9109 3 leucoreduced leucoreduce VBN cord-010119-t1x9gknd 9109 4 irradiated irradiate VBD cord-010119-t1x9gknd 9109 5 SDA SDA NNP cord-010119-t1x9gknd 9109 6 platelets platelet NNS cord-010119-t1x9gknd 9109 7 were be VBD cord-010119-t1x9gknd 9109 8 transfused transfuse VBN cord-010119-t1x9gknd 9109 9 to to IN cord-010119-t1x9gknd 9109 10 17 17 CD cord-010119-t1x9gknd 9109 11 ( ( -LRB- cord-010119-t1x9gknd 9109 12 6M/11F 6m/11f CD cord-010119-t1x9gknd 9109 13 ) ) -RRB- cord-010119-t1x9gknd 9109 14 patients patient NNS cord-010119-t1x9gknd 9109 15 , , , cord-010119-t1x9gknd 9109 16 median median JJ cord-010119-t1x9gknd 9109 17 age age NN cord-010119-t1x9gknd 9109 18 60 60 CD cord-010119-t1x9gknd 9109 19 years year NNS cord-010119-t1x9gknd 9109 20 ( ( -LRB- cord-010119-t1x9gknd 9109 21 range range VBP cord-010119-t1x9gknd 9109 22 27 27 CD cord-010119-t1x9gknd 9109 23 - - SYM cord-010119-t1x9gknd 9109 24 83 83 CD cord-010119-t1x9gknd 9109 25 ) ) -RRB- cord-010119-t1x9gknd 9109 26 . . . cord-010119-t1x9gknd 9110 1 15/17 15/17 CD cord-010119-t1x9gknd 9110 2 ( ( -LRB- cord-010119-t1x9gknd 9110 3 88 88 CD cord-010119-t1x9gknd 9110 4 % % NN cord-010119-t1x9gknd 9110 5 ) ) -RRB- cord-010119-t1x9gknd 9110 6 patients patient NNS cord-010119-t1x9gknd 9110 7 showing show VBG cord-010119-t1x9gknd 9110 8 broad broad JJ cord-010119-t1x9gknd 9110 9 alloimmunization alloimmunization NN cord-010119-t1x9gknd 9110 10 to to IN cord-010119-t1x9gknd 9110 11 HLA HLA NNP cord-010119-t1x9gknd 9110 12 Class Class NNP cord-010119-t1x9gknd 9110 13 I I NNP cord-010119-t1x9gknd 9110 14 / / SYM cord-010119-t1x9gknd 9110 15 Class Class NNP cord-010119-t1x9gknd 9110 16 II II NNP cord-010119-t1x9gknd 9110 17 antigens antigen NNS cord-010119-t1x9gknd 9110 18 . . . cord-010119-t1x9gknd 9111 1 2/17(12 2/17(12 CD cord-010119-t1x9gknd 9111 2 % % NN cord-010119-t1x9gknd 9111 3 ) ) -RRB- cord-010119-t1x9gknd 9112 1 patients patient NNS cord-010119-t1x9gknd 9112 2 had have VBD cord-010119-t1x9gknd 9112 3 anti anti JJ cord-010119-t1x9gknd 9112 4 - - JJ cord-010119-t1x9gknd 9112 5 HPA hpa JJ cord-010119-t1x9gknd 9112 6 antibodies antibody NNS cord-010119-t1x9gknd 9112 7 ( ( -LRB- cord-010119-t1x9gknd 9112 8 GP GP NNP cord-010119-t1x9gknd 9112 9 IIb IIb NNP cord-010119-t1x9gknd 9112 10 / / SYM cord-010119-t1x9gknd 9112 11 IIIa IIIa NNS cord-010119-t1x9gknd 9112 12 and and CC cord-010119-t1x9gknd 9112 13 GP GP NNP cord-010119-t1x9gknd 9112 14 IIb IIb NNP cord-010119-t1x9gknd 9112 15 / / SYM cord-010119-t1x9gknd 9112 16 IIIa IIIa NNS cord-010119-t1x9gknd 9112 17 and and CC cord-010119-t1x9gknd 9112 18 GP GP NNP cord-010119-t1x9gknd 9112 19 Ia Ia NNP cord-010119-t1x9gknd 9112 20 / / SYM cord-010119-t1x9gknd 9112 21 IIa IIa NNP cord-010119-t1x9gknd 9112 22 ) ) -RRB- cord-010119-t1x9gknd 9112 23 . . . cord-010119-t1x9gknd 9113 1 The the DT cord-010119-t1x9gknd 9113 2 majority majority NN cord-010119-t1x9gknd 9113 3 16/17 16/17 CD cord-010119-t1x9gknd 9113 4 ( ( -LRB- cord-010119-t1x9gknd 9113 5 94 94 CD cord-010119-t1x9gknd 9113 6 % % NN cord-010119-t1x9gknd 9113 7 ) ) -RRB- cord-010119-t1x9gknd 9113 8 had have VBD cord-010119-t1x9gknd 9113 9 a a DT cord-010119-t1x9gknd 9113 10 diagnosis diagnosis NN cord-010119-t1x9gknd 9113 11 of of IN cord-010119-t1x9gknd 9113 12 hematologic hematologic JJ cord-010119-t1x9gknd 9113 13 malignancy malignancy NN cord-010119-t1x9gknd 9113 14 ( ( -LRB- cord-010119-t1x9gknd 9113 15 AML AML NNP cord-010119-t1x9gknd 9113 16 / / SYM cord-010119-t1x9gknd 9113 17 MDS MDS NNP cord-010119-t1x9gknd 9113 18 / / SYM cord-010119-t1x9gknd 9113 19 MPN/ MPN/ NNP cord-010119-t1x9gknd 9113 20 CMML CMML NNP cord-010119-t1x9gknd 9113 21 / / SYM cord-010119-t1x9gknd 9113 22 MM MM NNP cord-010119-t1x9gknd 9113 23 ) ) -RRB- cord-010119-t1x9gknd 9113 24 ; ; : cord-010119-t1x9gknd 9113 25 9/11 9/11 CD cord-010119-t1x9gknd 9113 26 ( ( -LRB- cord-010119-t1x9gknd 9113 27 81 81 CD cord-010119-t1x9gknd 9113 28 % % NN cord-010119-t1x9gknd 9113 29 ) ) -RRB- cord-010119-t1x9gknd 9113 30 female female JJ cord-010119-t1x9gknd 9113 31 patients patient NNS cord-010119-t1x9gknd 9113 32 had have VBD cord-010119-t1x9gknd 9113 33 prior prior JJ cord-010119-t1x9gknd 9113 34 exposure exposure NN cord-010119-t1x9gknd 9113 35 via via IN cord-010119-t1x9gknd 9113 36 pregnancy pregnancy NN cord-010119-t1x9gknd 9113 37 and and CC cord-010119-t1x9gknd 9113 38 4/11 4/11 CD cord-010119-t1x9gknd 9113 39 ( ( -LRB- cord-010119-t1x9gknd 9113 40 24 24 CD cord-010119-t1x9gknd 9113 41 % % NN cord-010119-t1x9gknd 9113 42 ) ) -RRB- cord-010119-t1x9gknd 9113 43 had have VBD cord-010119-t1x9gknd 9113 44 a a DT cord-010119-t1x9gknd 9113 45 history history NN cord-010119-t1x9gknd 9113 46 of of IN cord-010119-t1x9gknd 9113 47 HSCT HSCT NNP cord-010119-t1x9gknd 9113 48 . . . cord-010119-t1x9gknd 9114 1 63 63 CD cord-010119-t1x9gknd 9114 2 ( ( -LRB- cord-010119-t1x9gknd 9114 3 51 51 CD cord-010119-t1x9gknd 9114 4 % % NN cord-010119-t1x9gknd 9114 5 ) ) -RRB- cord-010119-t1x9gknd 9114 6 platelets platelet NNS cord-010119-t1x9gknd 9114 7 were be VBD cord-010119-t1x9gknd 9114 8 ABO ABO NNP cord-010119-t1x9gknd 9114 9 identical identical JJ cord-010119-t1x9gknd 9114 10 - - HYPH cord-010119-t1x9gknd 9114 11 platelet platelet NN cord-010119-t1x9gknd 9114 12 increment increment NN cord-010119-t1x9gknd 9114 13 median median NN cord-010119-t1x9gknd 9114 14 7 7 CD cord-010119-t1x9gknd 9114 15 K k NN cord-010119-t1x9gknd 9114 16 / / SYM cord-010119-t1x9gknd 9114 17 uL ul NN cord-010119-t1x9gknd 9115 1 ( ( -LRB- cord-010119-t1x9gknd 9115 2 range range NN cord-010119-t1x9gknd 9115 3 -14 -14 RB cord-010119-t1x9gknd 9115 4 to to IN cord-010119-t1x9gknd 9115 5 61 61 CD cord-010119-t1x9gknd 9115 6 ) ) -RRB- cord-010119-t1x9gknd 9115 7 , , , cord-010119-t1x9gknd 9115 8 53 53 CD cord-010119-t1x9gknd 9115 9 ( ( -LRB- cord-010119-t1x9gknd 9115 10 43 43 CD cord-010119-t1x9gknd 9115 11 % % NN cord-010119-t1x9gknd 9115 12 ) ) -RRB- cord-010119-t1x9gknd 9115 13 were be VBD cord-010119-t1x9gknd 9115 14 ABO ABO NNP cord-010119-t1x9gknd 9115 15 compatible compatible JJ cord-010119-t1x9gknd 9115 16 -platelet -platelet SYM cord-010119-t1x9gknd 9115 17 increment increment NN cord-010119-t1x9gknd 9115 18 median median NN cord-010119-t1x9gknd 9115 19 of of IN cord-010119-t1x9gknd 9115 20 2K 2K NNP cord-010119-t1x9gknd 9115 21 / / SYM cord-010119-t1x9gknd 9115 22 uL uL NNP cord-010119-t1x9gknd 9115 23 ( ( -LRB- cord-010119-t1x9gknd 9115 24 range range NN cord-010119-t1x9gknd 9115 25 -10 -10 NN cord-010119-t1x9gknd 9115 26 to to IN cord-010119-t1x9gknd 9115 27 46 46 CD cord-010119-t1x9gknd 9115 28 ) ) -RRB- cord-010119-t1x9gknd 9115 29 and and CC cord-010119-t1x9gknd 9115 30 7(6 7(6 CD cord-010119-t1x9gknd 9115 31 % % NN cord-010119-t1x9gknd 9115 32 ) ) -RRB- cord-010119-t1x9gknd 9115 33 were be VBD cord-010119-t1x9gknd 9115 34 ABO ABO NNP cord-010119-t1x9gknd 9115 35 incompatible incompatible JJ cord-010119-t1x9gknd 9115 36 with with IN cord-010119-t1x9gknd 9115 37 platelet platelet NN cord-010119-t1x9gknd 9115 38 increments increment NNS cord-010119-t1x9gknd 9116 1 median median NNP cord-010119-t1x9gknd 9116 2 8K 8k CD cord-010119-t1x9gknd 9116 3 / / SYM cord-010119-t1x9gknd 9116 4 uL ul NN cord-010119-t1x9gknd 9116 5 ( ( -LRB- cord-010119-t1x9gknd 9116 6 range range NN cord-010119-t1x9gknd 9116 7 -10 -10 NN cord-010119-t1x9gknd 9116 8 to to IN cord-010119-t1x9gknd 9116 9 32 32 CD cord-010119-t1x9gknd 9116 10 ) ) -RRB- cord-010119-t1x9gknd 9116 11 . . . cord-010119-t1x9gknd 9117 1 Platelet platelet NN cord-010119-t1x9gknd 9117 2 counts count NNS cord-010119-t1x9gknd 9117 3 were be VBD cord-010119-t1x9gknd 9117 4 performed perform VBN cord-010119-t1x9gknd 9117 5 within within IN cord-010119-t1x9gknd 9117 6 24 24 CD cord-010119-t1x9gknd 9117 7 hours hour NNS cord-010119-t1x9gknd 9117 8 in in IN cord-010119-t1x9gknd 9117 9 73 73 CD cord-010119-t1x9gknd 9117 10 ( ( -LRB- cord-010119-t1x9gknd 9117 11 57 57 CD cord-010119-t1x9gknd 9117 12 % % NN cord-010119-t1x9gknd 9117 13 ) ) -RRB- cord-010119-t1x9gknd 9117 14 transfusions transfusion NNS cord-010119-t1x9gknd 9117 15 . . . cord-010119-t1x9gknd 9118 1 The the DT cord-010119-t1x9gknd 9118 2 HLA HLA NNP cord-010119-t1x9gknd 9118 3 match match NN cord-010119-t1x9gknd 9118 4 grade grade NN cord-010119-t1x9gknd 9118 5 of of IN cord-010119-t1x9gknd 9118 6 the the DT cord-010119-t1x9gknd 9118 7 transfused transfuse VBN cord-010119-t1x9gknd 9118 8 platelets platelet NNS cord-010119-t1x9gknd 9118 9 were be VBD cord-010119-t1x9gknd 9118 10 as as IN cord-010119-t1x9gknd 9118 11 follows follow VBZ cord-010119-t1x9gknd 9118 12 : : : cord-010119-t1x9gknd 9118 13 _SP cord-010119-t1x9gknd 9119 1 The the DT cord-010119-t1x9gknd 9119 2 Use Use NNP cord-010119-t1x9gknd 9119 3 of of IN cord-010119-t1x9gknd 9119 4 Massive Massive NNP cord-010119-t1x9gknd 9119 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 9119 6 Protocol Protocol NNP cord-010119-t1x9gknd 9119 7 ( ( -LRB- cord-010119-t1x9gknd 9119 8 MTP MTP NNP cord-010119-t1x9gknd 9119 9 ) ) -RRB- cord-010119-t1x9gknd 9119 10 in in IN cord-010119-t1x9gknd 9119 11 a a DT cord-010119-t1x9gknd 9119 12 Community Community NNP cord-010119-t1x9gknd 9119 13 Hospital Hospital NNP cord-010119-t1x9gknd 9119 14 Rohini Rohini NNP cord-010119-t1x9gknd 9119 15 Patel Patel NNP cord-010119-t1x9gknd 9119 16 * * NFP cord-010119-t1x9gknd 9119 17 1 1 CD cord-010119-t1x9gknd 9119 18 , , , cord-010119-t1x9gknd 9119 19 Renee Renee NNP cord-010119-t1x9gknd 9119 20 LeBlanc LeBlanc NNP cord-010119-t1x9gknd 9119 21 2 2 CD cord-010119-t1x9gknd 9119 22 , , , cord-010119-t1x9gknd 9119 23 Dongfu Dongfu NNP cord-010119-t1x9gknd 9119 24 Xie Xie NNP cord-010119-t1x9gknd 9119 25 2 2 CD cord-010119-t1x9gknd 9119 26 , , , cord-010119-t1x9gknd 9119 27 Alice Alice NNP cord-010119-t1x9gknd 9119 28 Cabe Cabe NNP cord-010119-t1x9gknd 9119 29 1 1 CD cord-010119-t1x9gknd 9119 30 and and CC cord-010119-t1x9gknd 9119 31 Yanyun Yanyun NNP cord-010119-t1x9gknd 9119 32 Wu Wu NNP cord-010119-t1x9gknd 9119 33 2 2 CD cord-010119-t1x9gknd 9119 34 . . . cord-010119-t1x9gknd 9120 1 1 1 CD cord-010119-t1x9gknd 9120 2 Overlake Overlake NNP cord-010119-t1x9gknd 9120 3 Hospital Hospital NNP cord-010119-t1x9gknd 9120 4 , , , cord-010119-t1x9gknd 9120 5 2 2 CD cord-010119-t1x9gknd 9120 6 Bloodworks Bloodworks NNP cord-010119-t1x9gknd 9120 7 Northwest Northwest NNP cord-010119-t1x9gknd 9121 1 The the DT cord-010119-t1x9gknd 9121 2 Use Use NNP cord-010119-t1x9gknd 9121 3 of of IN cord-010119-t1x9gknd 9121 4 Massive Massive NNP cord-010119-t1x9gknd 9121 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 9121 6 Protocol Protocol NNP cord-010119-t1x9gknd 9121 7 ( ( -LRB- cord-010119-t1x9gknd 9121 8 MTP MTP NNP cord-010119-t1x9gknd 9121 9 ) ) -RRB- cord-010119-t1x9gknd 9121 10 in in IN cord-010119-t1x9gknd 9121 11 a a DT cord-010119-t1x9gknd 9121 12 Community Community NNP cord-010119-t1x9gknd 9121 13 Hospital Hospital NNP cord-010119-t1x9gknd 9121 14 Background Background NNP cord-010119-t1x9gknd 9121 15 / / SYM cord-010119-t1x9gknd 9121 16 Case Case NNP cord-010119-t1x9gknd 9121 17 Studies Studies NNPS cord-010119-t1x9gknd 9121 18 : : : cord-010119-t1x9gknd 9121 19 The the DT cord-010119-t1x9gknd 9121 20 establishment establishment NN cord-010119-t1x9gknd 9121 21 and and CC cord-010119-t1x9gknd 9121 22 use use NN cord-010119-t1x9gknd 9121 23 of of IN cord-010119-t1x9gknd 9121 24 massive massive JJ cord-010119-t1x9gknd 9121 25 transfusion transfusion NN cord-010119-t1x9gknd 9121 26 protocol protocol NN cord-010119-t1x9gknd 9121 27 ( ( -LRB- cord-010119-t1x9gknd 9121 28 MTP MTP NNP cord-010119-t1x9gknd 9121 29 ) ) -RRB- cord-010119-t1x9gknd 9121 30 have have VBP cord-010119-t1x9gknd 9121 31 become become VBN cord-010119-t1x9gknd 9121 32 common common JJ cord-010119-t1x9gknd 9121 33 practice practice NN cord-010119-t1x9gknd 9121 34 , , , cord-010119-t1x9gknd 9121 35 especially especially RB cord-010119-t1x9gknd 9121 36 in in IN cord-010119-t1x9gknd 9121 37 trauma trauma NN cord-010119-t1x9gknd 9121 38 centers center NNS cord-010119-t1x9gknd 9121 39 and and CC cord-010119-t1x9gknd 9121 40 tertiary tertiary JJ cord-010119-t1x9gknd 9121 41 hospitals hospital NNS cord-010119-t1x9gknd 9121 42 due due JJ cord-010119-t1x9gknd 9121 43 to to IN cord-010119-t1x9gknd 9121 44 significant significant JJ cord-010119-t1x9gknd 9121 45 number number NN cord-010119-t1x9gknd 9121 46 of of IN cord-010119-t1x9gknd 9121 47 patients patient NNS cord-010119-t1x9gknd 9121 48 with with IN cord-010119-t1x9gknd 9121 49 massive massive JJ cord-010119-t1x9gknd 9121 50 bleeding bleeding NN cord-010119-t1x9gknd 9121 51 . . . cord-010119-t1x9gknd 9122 1 However however RB cord-010119-t1x9gknd 9122 2 , , , cord-010119-t1x9gknd 9122 3 it -PRON- PRP cord-010119-t1x9gknd 9122 4 is be VBZ cord-010119-t1x9gknd 9122 5 not not RB cord-010119-t1x9gknd 9122 6 well well RB cord-010119-t1x9gknd 9122 7 established establish VBN cord-010119-t1x9gknd 9122 8 if if IN cord-010119-t1x9gknd 9122 9 the the DT cord-010119-t1x9gknd 9122 10 use use NN cord-010119-t1x9gknd 9122 11 of of IN cord-010119-t1x9gknd 9122 12 MTP MTP NNP cord-010119-t1x9gknd 9122 13 also also RB cord-010119-t1x9gknd 9122 14 has have VBZ cord-010119-t1x9gknd 9122 15 value value NN cord-010119-t1x9gknd 9122 16 in in IN cord-010119-t1x9gknd 9122 17 small small JJ cord-010119-t1x9gknd 9122 18 hospitals hospital NNS cord-010119-t1x9gknd 9122 19 and and CC cord-010119-t1x9gknd 9122 20 community community NN cord-010119-t1x9gknd 9122 21 hospitals hospital NNS cord-010119-t1x9gknd 9122 22 , , , cord-010119-t1x9gknd 9122 23 and and CC cord-010119-t1x9gknd 9122 24 how how WRB cord-010119-t1x9gknd 9122 25 MTP MTP NNP cord-010119-t1x9gknd 9122 26 is be VBZ cord-010119-t1x9gknd 9122 27 used use VBN cord-010119-t1x9gknd 9122 28 in in IN cord-010119-t1x9gknd 9122 29 Fig Fig NNP cord-010119-t1x9gknd 9122 30 . . . cord-010119-t1x9gknd 9123 1 1 1 LS cord-010119-t1x9gknd 9124 1 these these DT cord-010119-t1x9gknd 9124 2 settings setting NNS cord-010119-t1x9gknd 9124 3 , , , cord-010119-t1x9gknd 9124 4 such such JJ cord-010119-t1x9gknd 9124 5 as as IN cord-010119-t1x9gknd 9124 6 indication indication NN cord-010119-t1x9gknd 9124 7 for for IN cord-010119-t1x9gknd 9124 8 MTP MTP NNP cord-010119-t1x9gknd 9124 9 , , , cord-010119-t1x9gknd 9124 10 blood blood NN cord-010119-t1x9gknd 9124 11 products product NNS cord-010119-t1x9gknd 9124 12 used use VBN cord-010119-t1x9gknd 9124 13 , , , cord-010119-t1x9gknd 9124 14 and and CC cord-010119-t1x9gknd 9124 15 the the DT cord-010119-t1x9gknd 9124 16 outcomes outcome NNS cord-010119-t1x9gknd 9124 17 of of IN cord-010119-t1x9gknd 9124 18 these these DT cord-010119-t1x9gknd 9124 19 patients patient NNS cord-010119-t1x9gknd 9124 20 . . . cord-010119-t1x9gknd 9125 1 Study Study NNP cord-010119-t1x9gknd 9125 2 Design Design NNP cord-010119-t1x9gknd 9125 3 / / SYM cord-010119-t1x9gknd 9125 4 Method method NN cord-010119-t1x9gknd 9125 5 : : : cord-010119-t1x9gknd 9126 1 Retrospective retrospective JJ cord-010119-t1x9gknd 9126 2 review review NN cord-010119-t1x9gknd 9126 3 of of IN cord-010119-t1x9gknd 9126 4 transfusion transfusion NN cord-010119-t1x9gknd 9126 5 data datum NNS cord-010119-t1x9gknd 9126 6 from from IN cord-010119-t1x9gknd 9126 7 a a DT cord-010119-t1x9gknd 9126 8 community community NN cord-010119-t1x9gknd 9126 9 hospital hospital NN cord-010119-t1x9gknd 9126 10 with with IN cord-010119-t1x9gknd 9126 11 a a DT cord-010119-t1x9gknd 9126 12 bed bed NN cord-010119-t1x9gknd 9126 13 size size NN cord-010119-t1x9gknd 9126 14 of of IN cord-010119-t1x9gknd 9126 15 about about RB cord-010119-t1x9gknd 9126 16 350 350 CD cord-010119-t1x9gknd 9126 17 for for IN cord-010119-t1x9gknd 9126 18 3 3 CD cord-010119-t1x9gknd 9126 19 years year NNS cord-010119-t1x9gknd 9126 20 ( ( -LRB- cord-010119-t1x9gknd 9126 21 from from IN cord-010119-t1x9gknd 9126 22 2014 2014 CD cord-010119-t1x9gknd 9126 23 to to IN cord-010119-t1x9gknd 9126 24 2016 2016 CD cord-010119-t1x9gknd 9126 25 ) ) -RRB- cord-010119-t1x9gknd 9126 26 was be VBD cord-010119-t1x9gknd 9126 27 performed perform VBN cord-010119-t1x9gknd 9126 28 . . . cord-010119-t1x9gknd 9127 1 Patients patient NNS cord-010119-t1x9gknd 9127 2 with with IN cord-010119-t1x9gknd 9127 3 MTP MTP NNP cord-010119-t1x9gknd 9127 4 requested request VBN cord-010119-t1x9gknd 9127 5 are be VBP cord-010119-t1x9gknd 9127 6 included include VBN cord-010119-t1x9gknd 9127 7 in in IN cord-010119-t1x9gknd 9127 8 this this DT cord-010119-t1x9gknd 9127 9 study study NN cord-010119-t1x9gknd 9127 10 . . . cord-010119-t1x9gknd 9128 1 Results result NNS cord-010119-t1x9gknd 9129 1 /Finding /finde VBG cord-010119-t1x9gknd 9129 2 : : : cord-010119-t1x9gknd 9129 3 Please please UH cord-010119-t1x9gknd 9129 4 see see VB cord-010119-t1x9gknd 9129 5 the the DT cord-010119-t1x9gknd 9129 6 table table NN cord-010119-t1x9gknd 9129 7 below below RB cord-010119-t1x9gknd 9129 8 for for IN cord-010119-t1x9gknd 9129 9 the the DT cord-010119-t1x9gknd 9129 10 summary summary NN cord-010119-t1x9gknd 9129 11 of of IN cord-010119-t1x9gknd 9129 12 data datum NNS cord-010119-t1x9gknd 9129 13 . . . cord-010119-t1x9gknd 9130 1 Notably notably RB cord-010119-t1x9gknd 9130 2 , , , cord-010119-t1x9gknd 9130 3 patients patient NNS cord-010119-t1x9gknd 9130 4 with with IN cord-010119-t1x9gknd 9130 5 GI GI NNP cord-010119-t1x9gknd 9130 6 bleed bleed NN cord-010119-t1x9gknd 9130 7 and and CC cord-010119-t1x9gknd 9130 8 OB OB NNP cord-010119-t1x9gknd 9130 9 bleed bleed NN cord-010119-t1x9gknd 9130 10 are be VBP cord-010119-t1x9gknd 9130 11 the the DT cord-010119-t1x9gknd 9130 12 two two CD cord-010119-t1x9gknd 9130 13 most most RBS cord-010119-t1x9gknd 9130 14 common common JJ cord-010119-t1x9gknd 9130 15 indications indication NNS cord-010119-t1x9gknd 9130 16 for for IN cord-010119-t1x9gknd 9130 17 MTP MTP NNP cord-010119-t1x9gknd 9130 18 , , , cord-010119-t1x9gknd 9130 19 and and CC cord-010119-t1x9gknd 9130 20 68 68 CD cord-010119-t1x9gknd 9130 21 % % NN cord-010119-t1x9gknd 9130 22 of of IN cord-010119-t1x9gknd 9130 23 patients patient NNS cord-010119-t1x9gknd 9130 24 survived survive VBN cord-010119-t1x9gknd 9130 25 with with IN cord-010119-t1x9gknd 9130 26 the the DT cord-010119-t1x9gknd 9130 27 support support NN cord-010119-t1x9gknd 9130 28 of of IN cord-010119-t1x9gknd 9130 29 MTP MTP NNP cord-010119-t1x9gknd 9130 30 . . . cord-010119-t1x9gknd 9131 1 In in IN cord-010119-t1x9gknd 9131 2 one one CD cord-010119-t1x9gknd 9131 3 case case NN cord-010119-t1x9gknd 9131 4 , , , cord-010119-t1x9gknd 9131 5 no no DT cord-010119-t1x9gknd 9131 6 blood blood NN cord-010119-t1x9gknd 9131 7 product product NN cord-010119-t1x9gknd 9131 8 was be VBD cord-010119-t1x9gknd 9131 9 used use VBN cord-010119-t1x9gknd 9131 10 . . . cord-010119-t1x9gknd 9132 1 The the DT cord-010119-t1x9gknd 9132 2 establishment establishment NN cord-010119-t1x9gknd 9132 3 and and CC cord-010119-t1x9gknd 9132 4 readiness readiness NN cord-010119-t1x9gknd 9132 5 of of IN cord-010119-t1x9gknd 9132 6 MTP MTP NNP cord-010119-t1x9gknd 9132 7 can can MD cord-010119-t1x9gknd 9132 8 be be VB cord-010119-t1x9gknd 9132 9 very very RB cord-010119-t1x9gknd 9132 10 important important JJ cord-010119-t1x9gknd 9132 11 in in IN cord-010119-t1x9gknd 9132 12 supporting support VBG cord-010119-t1x9gknd 9132 13 patients patient NNS cord-010119-t1x9gknd 9132 14 who who WP cord-010119-t1x9gknd 9132 15 experience experience VBP cord-010119-t1x9gknd 9132 16 massive massive JJ cord-010119-t1x9gknd 9132 17 bleed bleed NN cord-010119-t1x9gknd 9132 18 in in IN cord-010119-t1x9gknd 9132 19 small small JJ cord-010119-t1x9gknd 9132 20 hospitals hospital NNS cord-010119-t1x9gknd 9132 21 and and CC cord-010119-t1x9gknd 9132 22 community community NN cord-010119-t1x9gknd 9132 23 hospitals hospital NNS cord-010119-t1x9gknd 9132 24 . . . cord-010119-t1x9gknd 9133 1 In in IN cord-010119-t1x9gknd 9133 2 these these DT cord-010119-t1x9gknd 9133 3 settings setting NNS cord-010119-t1x9gknd 9133 4 , , , cord-010119-t1x9gknd 9133 5 MTP MTP NNP cord-010119-t1x9gknd 9133 6 is be VBZ cord-010119-t1x9gknd 9133 7 most most RBS cord-010119-t1x9gknd 9133 8 commonly commonly RB cord-010119-t1x9gknd 9133 9 used use VBN cord-010119-t1x9gknd 9133 10 for for IN cord-010119-t1x9gknd 9133 11 patients patient NNS cord-010119-t1x9gknd 9133 12 with with IN cord-010119-t1x9gknd 9133 13 massive massive JJ cord-010119-t1x9gknd 9133 14 GI gi NN cord-010119-t1x9gknd 9133 15 bleed bleed NN cord-010119-t1x9gknd 9133 16 and and CC cord-010119-t1x9gknd 9133 17 Ob Ob NNP cord-010119-t1x9gknd 9133 18 bleed bleed NN cord-010119-t1x9gknd 9133 19 . . . cord-010119-t1x9gknd 9134 1 If if IN cord-010119-t1x9gknd 9134 2 the the DT cord-010119-t1x9gknd 9134 3 patient patient NN cord-010119-t1x9gknd 9134 4 develops develop VBZ cord-010119-t1x9gknd 9134 5 antibodies antibody NNS cord-010119-t1x9gknd 9134 6 to to IN cord-010119-t1x9gknd 9134 7 a a DT cord-010119-t1x9gknd 9134 8 high high JJ cord-010119-t1x9gknd 9134 9 incidence incidence NN cord-010119-t1x9gknd 9134 10 antigen antigen NN cord-010119-t1x9gknd 9134 11 , , , cord-010119-t1x9gknd 9134 12 finding find VBG cord-010119-t1x9gknd 9134 13 compatible compatible JJ cord-010119-t1x9gknd 9134 14 units unit NNS cord-010119-t1x9gknd 9134 15 may may MD cord-010119-t1x9gknd 9134 16 become become VB cord-010119-t1x9gknd 9134 17 impossible impossible JJ cord-010119-t1x9gknd 9134 18 . . . cord-010119-t1x9gknd 9135 1 Included include VBN cord-010119-t1x9gknd 9135 2 in in IN cord-010119-t1x9gknd 9135 3 the the DT cord-010119-t1x9gknd 9135 4 MNS MNS NNP cord-010119-t1x9gknd 9135 5 system system NN cord-010119-t1x9gknd 9135 6 , , , cord-010119-t1x9gknd 9135 7 and and CC cord-010119-t1x9gknd 9135 8 residing reside VBG cord-010119-t1x9gknd 9135 9 on on IN cord-010119-t1x9gknd 9135 10 Glycophorin Glycophorin NNP cord-010119-t1x9gknd 9135 11 B B NNP cord-010119-t1x9gknd 9135 12 ( ( -LRB- cord-010119-t1x9gknd 9135 13 GPB GPB NNP cord-010119-t1x9gknd 9135 14 ) ) -RRB- cord-010119-t1x9gknd 9135 15 , , , cord-010119-t1x9gknd 9135 16 the the DT cord-010119-t1x9gknd 9135 17 U U NNP cord-010119-t1x9gknd 9135 18 antigen antigen NNP cord-010119-t1x9gknd 9135 19 is be VBZ cord-010119-t1x9gknd 9135 20 absent absent JJ cord-010119-t1x9gknd 9135 21 in in IN cord-010119-t1x9gknd 9135 22 less less JJR cord-010119-t1x9gknd 9135 23 than than IN cord-010119-t1x9gknd 9135 24 0.25 0.25 CD cord-010119-t1x9gknd 9135 25 % % NN cord-010119-t1x9gknd 9135 26 of of IN cord-010119-t1x9gknd 9135 27 the the DT cord-010119-t1x9gknd 9135 28 black black JJ cord-010119-t1x9gknd 9135 29 population population NN cord-010119-t1x9gknd 9135 30 . . . cord-010119-t1x9gknd 9136 1 Those those DT cord-010119-t1x9gknd 9136 2 with with IN cord-010119-t1x9gknd 9136 3 altered altered JJ cord-010119-t1x9gknd 9136 4 forms form NNS cord-010119-t1x9gknd 9136 5 of of IN cord-010119-t1x9gknd 9136 6 GPB GPB NNP cord-010119-t1x9gknd 9136 7 , , , cord-010119-t1x9gknd 9136 8 known know VBN cord-010119-t1x9gknd 9136 9 as as IN cord-010119-t1x9gknd 9136 10 U U NNP cord-010119-t1x9gknd 9136 11 variants variant NNS cord-010119-t1x9gknd 9136 12 , , , cord-010119-t1x9gknd 9136 13 can can MD cord-010119-t1x9gknd 9136 14 produce produce VB cord-010119-t1x9gknd 9136 15 a a DT cord-010119-t1x9gknd 9136 16 diverse diverse JJ cord-010119-t1x9gknd 9136 17 group group NN cord-010119-t1x9gknd 9136 18 of of IN cord-010119-t1x9gknd 9136 19 antibodies antibody NNS cord-010119-t1x9gknd 9136 20 capable capable JJ cord-010119-t1x9gknd 9136 21 of of IN cord-010119-t1x9gknd 9136 22 causing cause VBG cord-010119-t1x9gknd 9136 23 mild mild JJ cord-010119-t1x9gknd 9136 24 to to IN cord-010119-t1x9gknd 9136 25 severe severe JJ cord-010119-t1x9gknd 9136 26 hemolytic hemolytic JJ cord-010119-t1x9gknd 9136 27 transfusion transfusion NN cord-010119-t1x9gknd 9136 28 reactions reaction NNS cord-010119-t1x9gknd 9136 29 and and CC cord-010119-t1x9gknd 9136 30 hemolytic hemolytic JJ cord-010119-t1x9gknd 9136 31 disease disease NN cord-010119-t1x9gknd 9136 32 of of IN cord-010119-t1x9gknd 9136 33 the the DT cord-010119-t1x9gknd 9136 34 fetus fetus NN cord-010119-t1x9gknd 9136 35 and and CC cord-010119-t1x9gknd 9136 36 newborn newborn JJ cord-010119-t1x9gknd 9136 37 ( ( -LRB- cord-010119-t1x9gknd 9136 38 HDFN HDFN NNP cord-010119-t1x9gknd 9136 39 ) ) -RRB- cord-010119-t1x9gknd 9136 40 . . . cord-010119-t1x9gknd 9137 1 This this DT cord-010119-t1x9gknd 9137 2 case case NN cord-010119-t1x9gknd 9137 3 illustrates illustrate VBZ cord-010119-t1x9gknd 9137 4 the the DT cord-010119-t1x9gknd 9137 5 balance balance NN cord-010119-t1x9gknd 9137 6 between between IN cord-010119-t1x9gknd 9137 7 the the DT cord-010119-t1x9gknd 9137 8 need need NN cord-010119-t1x9gknd 9137 9 to to TO cord-010119-t1x9gknd 9137 10 transfuse transfuse VB cord-010119-t1x9gknd 9137 11 and and CC cord-010119-t1x9gknd 9137 12 avoiding avoid VBG cord-010119-t1x9gknd 9137 13 complications complication NNS cord-010119-t1x9gknd 9137 14 thereof thereof RB cord-010119-t1x9gknd 9137 15 . . . cord-010119-t1x9gknd 9138 1 A a DT cord-010119-t1x9gknd 9138 2 32-year 32-year JJ cord-010119-t1x9gknd 9138 3 - - HYPH cord-010119-t1x9gknd 9138 4 old old JJ cord-010119-t1x9gknd 9138 5 Ghanaian ghanaian JJ cord-010119-t1x9gknd 9138 6 woman woman NN cord-010119-t1x9gknd 9138 7 with with IN cord-010119-t1x9gknd 9138 8 SCD SCD NNP cord-010119-t1x9gknd 9138 9 and and CC cord-010119-t1x9gknd 9138 10 history history NN cord-010119-t1x9gknd 9138 11 of of IN cord-010119-t1x9gknd 9138 12 chronic chronic JJ cord-010119-t1x9gknd 9138 13 transfusion transfusion NN cord-010119-t1x9gknd 9138 14 presented present VBN cord-010119-t1x9gknd 9138 15 with with IN cord-010119-t1x9gknd 9138 16 diffuse diffuse JJ cord-010119-t1x9gknd 9138 17 pain pain NN cord-010119-t1x9gknd 9138 18 and and CC cord-010119-t1x9gknd 9138 19 a a DT cord-010119-t1x9gknd 9138 20 hemoglobin hemoglobin NN cord-010119-t1x9gknd 9138 21 value value NN cord-010119-t1x9gknd 9138 22 of of IN cord-010119-t1x9gknd 9138 23 6.4 6.4 CD cord-010119-t1x9gknd 9138 24 g g NN cord-010119-t1x9gknd 9138 25 / / SYM cord-010119-t1x9gknd 9138 26 dL dl NN cord-010119-t1x9gknd 9138 27 ( ( -LRB- cord-010119-t1x9gknd 9138 28 baseline baseline JJ cord-010119-t1x9gknd 9138 29 9 9 CD cord-010119-t1x9gknd 9138 30 - - SYM cord-010119-t1x9gknd 9138 31 10 10 CD cord-010119-t1x9gknd 9138 32 g g NN cord-010119-t1x9gknd 9138 33 / / SYM cord-010119-t1x9gknd 9138 34 dL dl NN cord-010119-t1x9gknd 9138 35 ) ) -RRB- cord-010119-t1x9gknd 9138 36 . . . cord-010119-t1x9gknd 9139 1 She -PRON- PRP cord-010119-t1x9gknd 9139 2 is be VBZ cord-010119-t1x9gknd 9139 3 known know VBN cord-010119-t1x9gknd 9139 4 to to TO cord-010119-t1x9gknd 9139 5 be be VB cord-010119-t1x9gknd 9139 6 E E NNP cord-010119-t1x9gknd 9139 7 , , , cord-010119-t1x9gknd 9139 8 C C NNP cord-010119-t1x9gknd 9139 9 , , , cord-010119-t1x9gknd 9139 10 K K NNP cord-010119-t1x9gknd 9139 11 , , , cord-010119-t1x9gknd 9139 12 Fya Fya NNP cord-010119-t1x9gknd 9139 13 , , , cord-010119-t1x9gknd 9139 14 Jkb Jkb NNP cord-010119-t1x9gknd 9139 15 , , , cord-010119-t1x9gknd 9139 16 S S NNP cord-010119-t1x9gknd 9139 17 , , , cord-010119-t1x9gknd 9140 1 s s POS cord-010119-t1x9gknd 9140 2 negative negative JJ cord-010119-t1x9gknd 9140 3 , , , cord-010119-t1x9gknd 9140 4 U u NN cord-010119-t1x9gknd 9140 5 variant variant NN cord-010119-t1x9gknd 9140 6 , , , cord-010119-t1x9gknd 9140 7 and and CC cord-010119-t1x9gknd 9140 8 has have VBZ cord-010119-t1x9gknd 9140 9 anti anti JJ cord-010119-t1x9gknd 9140 10 - - JJ cord-010119-t1x9gknd 9140 11 E e JJ cord-010119-t1x9gknd 9140 12 , , , cord-010119-t1x9gknd 9140 13 C C NNP cord-010119-t1x9gknd 9140 14 and and CC cord-010119-t1x9gknd 9140 15 U U NNP cord-010119-t1x9gknd 9140 16 antibodies antibody NNS cord-010119-t1x9gknd 9140 17 . . . cord-010119-t1x9gknd 9141 1 There there EX cord-010119-t1x9gknd 9141 2 were be VBD cord-010119-t1x9gknd 9141 3 no no DT cord-010119-t1x9gknd 9141 4 eligible eligible JJ cord-010119-t1x9gknd 9141 5 family family NN cord-010119-t1x9gknd 9141 6 donors donor NNS cord-010119-t1x9gknd 9141 7 and and CC cord-010119-t1x9gknd 9141 8 a a DT cord-010119-t1x9gknd 9141 9 nationwide nationwide JJ cord-010119-t1x9gknd 9141 10 search search NN cord-010119-t1x9gknd 9141 11 for for IN cord-010119-t1x9gknd 9141 12 compatible compatible JJ cord-010119-t1x9gknd 9141 13 blood blood NN cord-010119-t1x9gknd 9141 14 yielded yield VBD cord-010119-t1x9gknd 9141 15 four four CD cord-010119-t1x9gknd 9141 16 crossmatch crossmatch NN cord-010119-t1x9gknd 9141 17 compatible compatible JJ cord-010119-t1x9gknd 9141 18 U u NN cord-010119-t1x9gknd 9141 19 variant variant NN cord-010119-t1x9gknd 9141 20 units unit NNS cord-010119-t1x9gknd 9141 21 . . . cord-010119-t1x9gknd 9142 1 The the DT cord-010119-t1x9gknd 9142 2 decision decision NN cord-010119-t1x9gknd 9142 3 to to TO cord-010119-t1x9gknd 9142 4 transfuse transfuse VB cord-010119-t1x9gknd 9142 5 was be VBD cord-010119-t1x9gknd 9142 6 made make VBN cord-010119-t1x9gknd 9142 7 . . . cord-010119-t1x9gknd 9143 1 The the DT cord-010119-t1x9gknd 9143 2 patient patient NN cord-010119-t1x9gknd 9143 3 had have VBD cord-010119-t1x9gknd 9143 4 no no DT cord-010119-t1x9gknd 9143 5 change change NN cord-010119-t1x9gknd 9143 6 in in IN cord-010119-t1x9gknd 9143 7 symptoms symptom NNS cord-010119-t1x9gknd 9143 8 or or CC cord-010119-t1x9gknd 9143 9 vital vital JJ cord-010119-t1x9gknd 9143 10 signs sign NNS cord-010119-t1x9gknd 9143 11 during during IN cord-010119-t1x9gknd 9143 12 transfusion transfusion NN cord-010119-t1x9gknd 9143 13 but but CC cord-010119-t1x9gknd 9143 14 post post JJ cord-010119-t1x9gknd 9143 15 - - JJ cord-010119-t1x9gknd 9143 16 transfusion transfusion JJ cord-010119-t1x9gknd 9143 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 9143 18 was be VBD cord-010119-t1x9gknd 9143 19 5.9 5.9 CD cord-010119-t1x9gknd 9144 1 g g NNP cord-010119-t1x9gknd 9144 2 / / SYM cord-010119-t1x9gknd 9144 3 dL. dL. NNP cord-010119-t1x9gknd 9145 1 A a DT cord-010119-t1x9gknd 9145 2 transfusion transfusion NN cord-010119-t1x9gknd 9145 3 reaction reaction NN cord-010119-t1x9gknd 9145 4 work work NN cord-010119-t1x9gknd 9145 5 - - HYPH cord-010119-t1x9gknd 9145 6 up up NN cord-010119-t1x9gknd 9145 7 was be VBD cord-010119-t1x9gknd 9145 8 ordered order VBN cord-010119-t1x9gknd 9145 9 . . . cord-010119-t1x9gknd 9146 1 Post post JJ cord-010119-t1x9gknd 9146 2 - - JJ cord-010119-t1x9gknd 9146 3 transfusion transfusion JJ cord-010119-t1x9gknd 9146 4 serum serum NN cord-010119-t1x9gknd 9146 5 sample sample NN cord-010119-t1x9gknd 9146 6 was be VBD cord-010119-t1x9gknd 9146 7 negative negative JJ cord-010119-t1x9gknd 9146 8 for for IN cord-010119-t1x9gknd 9146 9 hemolysis hemolysis NN cord-010119-t1x9gknd 9146 10 and and CC cord-010119-t1x9gknd 9146 11 no no DT cord-010119-t1x9gknd 9146 12 new new JJ cord-010119-t1x9gknd 9146 13 antibodies antibody NNS cord-010119-t1x9gknd 9146 14 were be VBD cord-010119-t1x9gknd 9146 15 identified identify VBN cord-010119-t1x9gknd 9146 16 . . . cord-010119-t1x9gknd 9147 1 The the DT cord-010119-t1x9gknd 9147 2 post post JJ cord-010119-t1x9gknd 9147 3 - - JJ cord-010119-t1x9gknd 9147 4 transfusion transfusion NN cord-010119-t1x9gknd 9147 5 DAT DAT NNP cord-010119-t1x9gknd 9147 6 was be VBD cord-010119-t1x9gknd 9147 7 weakly weakly RB cord-010119-t1x9gknd 9147 8 positive positive JJ cord-010119-t1x9gknd 9147 9 only only RB cord-010119-t1x9gknd 9147 10 with with IN cord-010119-t1x9gknd 9147 11 complement complement NN cord-010119-t1x9gknd 9147 12 and and CC cord-010119-t1x9gknd 9147 13 laboratory laboratory NN cord-010119-t1x9gknd 9147 14 data datum NNS cord-010119-t1x9gknd 9147 15 revealed reveal VBD cord-010119-t1x9gknd 9147 16 a a DT cord-010119-t1x9gknd 9147 17 decrease decrease NN cord-010119-t1x9gknd 9147 18 in in IN cord-010119-t1x9gknd 9147 19 total total JJ cord-010119-t1x9gknd 9147 20 bilirubin bilirubin NN cord-010119-t1x9gknd 9147 21 ( ( -LRB- cord-010119-t1x9gknd 9147 22 8.8 8.8 CD cord-010119-t1x9gknd 9147 23 to to IN cord-010119-t1x9gknd 9147 24 6.2 6.2 CD cord-010119-t1x9gknd 9147 25 mg mg NNP cord-010119-t1x9gknd 9147 26 / / SYM cord-010119-t1x9gknd 9147 27 dL dl NN cord-010119-t1x9gknd 9147 28 ) ) -RRB- cord-010119-t1x9gknd 9147 29 . . . cord-010119-t1x9gknd 9148 1 Two two CD cord-010119-t1x9gknd 9148 2 additional additional JJ cord-010119-t1x9gknd 9148 3 U u NN cord-010119-t1x9gknd 9148 4 variant variant NN cord-010119-t1x9gknd 9148 5 , , , cord-010119-t1x9gknd 9148 6 crossmatch crossmatch NN cord-010119-t1x9gknd 9148 7 compatible compatible JJ cord-010119-t1x9gknd 9148 8 units unit NNS cord-010119-t1x9gknd 9148 9 were be VBD cord-010119-t1x9gknd 9148 10 transfused transfuse VBN cord-010119-t1x9gknd 9148 11 over over IN cord-010119-t1x9gknd 9148 12 the the DT cord-010119-t1x9gknd 9148 13 next next JJ cord-010119-t1x9gknd 9148 14 two two CD cord-010119-t1x9gknd 9148 15 days day NNS cord-010119-t1x9gknd 9148 16 restoring restore VBG cord-010119-t1x9gknd 9148 17 her -PRON- PRP$ cord-010119-t1x9gknd 9148 18 hemoglobin hemoglobin NN cord-010119-t1x9gknd 9148 19 to to IN cord-010119-t1x9gknd 9148 20 6.2 6.2 CD cord-010119-t1x9gknd 9148 21 g g NN cord-010119-t1x9gknd 9148 22 / / SYM cord-010119-t1x9gknd 9148 23 dL. dl. NN cord-010119-t1x9gknd 9149 1 The the DT cord-010119-t1x9gknd 9149 2 patient patient NN cord-010119-t1x9gknd 9149 3 was be VBD cord-010119-t1x9gknd 9149 4 discharged discharge VBN cord-010119-t1x9gknd 9149 5 to to IN cord-010119-t1x9gknd 9149 6 home home NN cord-010119-t1x9gknd 9149 7 in in IN cord-010119-t1x9gknd 9149 8 stable stable JJ cord-010119-t1x9gknd 9149 9 condition condition NN cord-010119-t1x9gknd 9149 10 and and CC cord-010119-t1x9gknd 9149 11 follow follow NN cord-010119-t1x9gknd 9149 12 - - HYPH cord-010119-t1x9gknd 9149 13 up up RP cord-010119-t1x9gknd 9149 14 hemoglobin hemoglobin NN cord-010119-t1x9gknd 9149 15 levels level NNS cord-010119-t1x9gknd 9149 16 continued continue VBD cord-010119-t1x9gknd 9149 17 to to TO cord-010119-t1x9gknd 9149 18 rise rise VB cord-010119-t1x9gknd 9149 19 back back RB cord-010119-t1x9gknd 9149 20 to to IN cord-010119-t1x9gknd 9149 21 baseline baseline NN cord-010119-t1x9gknd 9149 22 . . . cord-010119-t1x9gknd 9150 1 Study Study NNP cord-010119-t1x9gknd 9150 2 Design Design NNP cord-010119-t1x9gknd 9150 3 / / SYM cord-010119-t1x9gknd 9150 4 Methods method NNS cord-010119-t1x9gknd 9150 5 : : : cord-010119-t1x9gknd 9150 6 Molecular molecular JJ cord-010119-t1x9gknd 9150 7 genotyping genotyping NN cord-010119-t1x9gknd 9150 8 was be VBD cord-010119-t1x9gknd 9150 9 used use VBN cord-010119-t1x9gknd 9150 10 in in IN cord-010119-t1x9gknd 9150 11 donor donor NN cord-010119-t1x9gknd 9150 12 unit unit NN cord-010119-t1x9gknd 9150 13 selection selection NN cord-010119-t1x9gknd 9150 14 prior prior RB cord-010119-t1x9gknd 9150 15 to to IN cord-010119-t1x9gknd 9150 16 compatibility compatibility NN cord-010119-t1x9gknd 9150 17 testing testing NN cord-010119-t1x9gknd 9150 18 by by IN cord-010119-t1x9gknd 9150 19 transfusion transfusion NN cord-010119-t1x9gknd 9150 20 services service NNS cord-010119-t1x9gknd 9150 21 . . . cord-010119-t1x9gknd 9151 1 Conventional conventional JJ cord-010119-t1x9gknd 9151 2 methods method NNS cord-010119-t1x9gknd 9151 3 were be VBD cord-010119-t1x9gknd 9151 4 used use VBN cord-010119-t1x9gknd 9151 5 to to TO cord-010119-t1x9gknd 9151 6 monitor monitor VB cord-010119-t1x9gknd 9151 7 the the DT cord-010119-t1x9gknd 9151 8 patient patient NN cord-010119-t1x9gknd 9151 9 's 's POS cord-010119-t1x9gknd 9151 10 condition condition NN cord-010119-t1x9gknd 9151 11 pre pre JJ cord-010119-t1x9gknd 9151 12 and and CC cord-010119-t1x9gknd 9151 13 posttransfusion posttransfusion NN cord-010119-t1x9gknd 9151 14 . . . cord-010119-t1x9gknd 9152 1 Results result NNS cord-010119-t1x9gknd 9152 2 / / SYM cord-010119-t1x9gknd 9152 3 Findings finding NNS cord-010119-t1x9gknd 9152 4 : : : cord-010119-t1x9gknd 9153 1 Each each DT cord-010119-t1x9gknd 9153 2 donor donor NN cord-010119-t1x9gknd 9153 3 unit unit NN cord-010119-t1x9gknd 9153 4 came come VBD cord-010119-t1x9gknd 9153 5 from from IN cord-010119-t1x9gknd 9153 6 a a DT cord-010119-t1x9gknd 9153 7 different different JJ cord-010119-t1x9gknd 9153 8 donor donor NN cord-010119-t1x9gknd 9153 9 but but CC cord-010119-t1x9gknd 9153 10 all all DT cord-010119-t1x9gknd 9153 11 were be VBD cord-010119-t1x9gknd 9153 12 the the DT cord-010119-t1x9gknd 9153 13 same same JJ cord-010119-t1x9gknd 9153 14 GPB GPB NNP cord-010119-t1x9gknd 9153 15 genotype genotype NN cord-010119-t1x9gknd 9153 16 as as IN cord-010119-t1x9gknd 9153 17 the the DT cord-010119-t1x9gknd 9153 18 patient patient NN cord-010119-t1x9gknd 9153 19 . . . cord-010119-t1x9gknd 9154 1 The the DT cord-010119-t1x9gknd 9154 2 patient patient NN cord-010119-t1x9gknd 9154 3 did do VBD cord-010119-t1x9gknd 9154 4 not not RB cord-010119-t1x9gknd 9154 5 experience experience VB cord-010119-t1x9gknd 9154 6 an an DT cord-010119-t1x9gknd 9154 7 acute acute JJ cord-010119-t1x9gknd 9154 8 or or CC cord-010119-t1x9gknd 9154 9 delayed delayed JJ cord-010119-t1x9gknd 9154 10 hemolytic hemolytic JJ cord-010119-t1x9gknd 9154 11 transfusion transfusion NN cord-010119-t1x9gknd 9154 12 reaction reaction NN cord-010119-t1x9gknd 9154 13 and and CC cord-010119-t1x9gknd 9154 14 genotype genotype NN cord-010119-t1x9gknd 9154 15 matching matching NN cord-010119-t1x9gknd 9154 16 successfully successfully RB cord-010119-t1x9gknd 9154 17 facilitated facilitate VBN cord-010119-t1x9gknd 9154 18 donor donor NN cord-010119-t1x9gknd 9154 19 unit unit NN cord-010119-t1x9gknd 9154 20 selection selection NN cord-010119-t1x9gknd 9154 21 in in IN cord-010119-t1x9gknd 9154 22 this this DT cord-010119-t1x9gknd 9154 23 case case NN cord-010119-t1x9gknd 9154 24 . . . cord-010119-t1x9gknd 9155 1 Conclusion conclusion NN cord-010119-t1x9gknd 9155 2 : : : cord-010119-t1x9gknd 9155 3 Transfusion transfusion NN cord-010119-t1x9gknd 9155 4 of of IN cord-010119-t1x9gknd 9155 5 U U NNP cord-010119-t1x9gknd 9155 6 variant variant NN cord-010119-t1x9gknd 9155 7 red red JJ cord-010119-t1x9gknd 9155 8 cells cell NNS cord-010119-t1x9gknd 9155 9 to to IN cord-010119-t1x9gknd 9155 10 a a DT cord-010119-t1x9gknd 9155 11 U u NN cord-010119-t1x9gknd 9155 12 variant variant NN cord-010119-t1x9gknd 9155 13 patient patient NN cord-010119-t1x9gknd 9155 14 should should MD cord-010119-t1x9gknd 9155 15 be be VB cord-010119-t1x9gknd 9155 16 undertaken undertake VBN cord-010119-t1x9gknd 9155 17 with with IN cord-010119-t1x9gknd 9155 18 great great JJ cord-010119-t1x9gknd 9155 19 caution caution NN cord-010119-t1x9gknd 9155 20 due due IN cord-010119-t1x9gknd 9155 21 to to IN cord-010119-t1x9gknd 9155 22 epitope epitope NN cord-010119-t1x9gknd 9155 23 and and CC cord-010119-t1x9gknd 9155 24 antibody antibody NN cord-010119-t1x9gknd 9155 25 heterogeneity heterogeneity NN cord-010119-t1x9gknd 9155 26 . . . cord-010119-t1x9gknd 9156 1 This this DT cord-010119-t1x9gknd 9156 2 case case NN cord-010119-t1x9gknd 9156 3 highlights highlight VBZ cord-010119-t1x9gknd 9156 4 the the DT cord-010119-t1x9gknd 9156 5 importance importance NN cord-010119-t1x9gknd 9156 6 of of IN cord-010119-t1x9gknd 9156 7 genotype genotype NN cord-010119-t1x9gknd 9156 8 compatibility compatibility NN cord-010119-t1x9gknd 9156 9 in in IN cord-010119-t1x9gknd 9156 10 selecting select VBG cord-010119-t1x9gknd 9156 11 donor donor NN cord-010119-t1x9gknd 9156 12 units unit NNS cord-010119-t1x9gknd 9156 13 for for IN cord-010119-t1x9gknd 9156 14 a a DT cord-010119-t1x9gknd 9156 15 chronically chronically RB cord-010119-t1x9gknd 9156 16 transfused transfuse VBN cord-010119-t1x9gknd 9156 17 , , , cord-010119-t1x9gknd 9156 18 SCD SCD NNP cord-010119-t1x9gknd 9156 19 patient patient NN cord-010119-t1x9gknd 9156 20 with with IN cord-010119-t1x9gknd 9156 21 anti anti JJ cord-010119-t1x9gknd 9156 22 - - JJ cord-010119-t1x9gknd 9156 23 U. U. NNP cord-010119-t1x9gknd 9156 24 Sound Sound NNP cord-010119-t1x9gknd 9156 25 transfusion transfusion NN cord-010119-t1x9gknd 9156 26 management management NN cord-010119-t1x9gknd 9156 27 of of IN cord-010119-t1x9gknd 9156 28 such such JJ cord-010119-t1x9gknd 9156 29 patients patient NNS cord-010119-t1x9gknd 9156 30 requires require VBZ cord-010119-t1x9gknd 9156 31 planning plan VBG cord-010119-t1x9gknd 9156 32 and and CC cord-010119-t1x9gknd 9156 33 good good JJ cord-010119-t1x9gknd 9156 34 communication communication NN cord-010119-t1x9gknd 9156 35 on on IN cord-010119-t1x9gknd 9156 36 the the DT cord-010119-t1x9gknd 9156 37 part part NN cord-010119-t1x9gknd 9156 38 of of IN cord-010119-t1x9gknd 9156 39 clinicians clinician NNS cord-010119-t1x9gknd 9156 40 and and CC cord-010119-t1x9gknd 9156 41 the the DT cord-010119-t1x9gknd 9156 42 laboratory laboratory NN cord-010119-t1x9gknd 9156 43 staff staff NN cord-010119-t1x9gknd 9156 44 . . . cord-010119-t1x9gknd 9157 1 Background Background NNP cord-010119-t1x9gknd 9157 2 / / SYM cord-010119-t1x9gknd 9157 3 Case Case NNP cord-010119-t1x9gknd 9157 4 Studies Studies NNPS cord-010119-t1x9gknd 9158 1 : : : cord-010119-t1x9gknd 9158 2 Patients patient NNS cord-010119-t1x9gknd 9158 3 with with IN cord-010119-t1x9gknd 9158 4 decompensated decompensated JJ cord-010119-t1x9gknd 9158 5 WAIHA WAIHA NNP cord-010119-t1x9gknd 9158 6 may may MD cord-010119-t1x9gknd 9158 7 require require VB cord-010119-t1x9gknd 9158 8 transfusion transfusion NN cord-010119-t1x9gknd 9158 9 with with IN cord-010119-t1x9gknd 9158 10 red red JJ cord-010119-t1x9gknd 9158 11 blood blood NN cord-010119-t1x9gknd 9158 12 cell cell NN cord-010119-t1x9gknd 9158 13 ( ( -LRB- cord-010119-t1x9gknd 9158 14 RBC RBC NNP cord-010119-t1x9gknd 9158 15 ) ) -RRB- cord-010119-t1x9gknd 9158 16 products product NNS cord-010119-t1x9gknd 9158 17 that that WDT cord-010119-t1x9gknd 9158 18 are be VBP cord-010119-t1x9gknd 9158 19 cross cross NN cord-010119-t1x9gknd 9158 20 - - JJ cord-010119-t1x9gknd 9158 21 match match NN cord-010119-t1x9gknd 9158 22 incompatible incompatible JJ cord-010119-t1x9gknd 9158 23 due due JJ cord-010119-t1x9gknd 9158 24 free free JJ cord-010119-t1x9gknd 9158 25 autoantibodies autoantibody NNS cord-010119-t1x9gknd 9158 26 . . . cord-010119-t1x9gknd 9159 1 The the DT cord-010119-t1x9gknd 9159 2 feasibility feasibility NN cord-010119-t1x9gknd 9159 3 of of IN cord-010119-t1x9gknd 9159 4 blood blood NN cord-010119-t1x9gknd 9159 5 transfusions transfusion NNS cord-010119-t1x9gknd 9159 6 in in IN cord-010119-t1x9gknd 9159 7 WAIHA WAIHA NNP cord-010119-t1x9gknd 9159 8 patients patient NNS cord-010119-t1x9gknd 9159 9 is be VBZ cord-010119-t1x9gknd 9159 10 controversial controversial JJ cord-010119-t1x9gknd 9159 11 because because IN cord-010119-t1x9gknd 9159 12 of of IN cord-010119-t1x9gknd 9159 13 difficulty difficulty NN cord-010119-t1x9gknd 9159 14 in in IN cord-010119-t1x9gknd 9159 15 cross cross JJ cord-010119-t1x9gknd 9159 16 - - JJ cord-010119-t1x9gknd 9159 17 matching matching JJ cord-010119-t1x9gknd 9159 18 and and CC cord-010119-t1x9gknd 9159 19 increased increased JJ cord-010119-t1x9gknd 9159 20 risk risk NN cord-010119-t1x9gknd 9159 21 of of IN cord-010119-t1x9gknd 9159 22 transfusion transfusion NN cord-010119-t1x9gknd 9159 23 reactions reaction NNS cord-010119-t1x9gknd 9159 24 , , , cord-010119-t1x9gknd 9159 25 since since IN cord-010119-t1x9gknd 9159 26 transfused transfuse VBN cord-010119-t1x9gknd 9159 27 RBCs rbc NNS cord-010119-t1x9gknd 9159 28 may may MD cord-010119-t1x9gknd 9159 29 be be VB cord-010119-t1x9gknd 9159 30 destroyed destroy VBN cord-010119-t1x9gknd 9159 31 more more RBR cord-010119-t1x9gknd 9159 32 rapidly rapidly RB cord-010119-t1x9gknd 9159 33 in in IN cord-010119-t1x9gknd 9159 34 patients patient NNS cord-010119-t1x9gknd 9159 35 with with IN cord-010119-t1x9gknd 9159 36 active active JJ cord-010119-t1x9gknd 9159 37 hemolysis hemolysis NN cord-010119-t1x9gknd 9159 38 . . . cord-010119-t1x9gknd 9160 1 To to TO cord-010119-t1x9gknd 9160 2 study study VB cord-010119-t1x9gknd 9160 3 the the DT cord-010119-t1x9gknd 9160 4 actual actual JJ cord-010119-t1x9gknd 9160 5 vs. vs. FW cord-010119-t1x9gknd 9160 6 theoretical theoretical JJ cord-010119-t1x9gknd 9160 7 risk risk NN cord-010119-t1x9gknd 9160 8 of of IN cord-010119-t1x9gknd 9160 9 increased increase VBN cord-010119-t1x9gknd 9160 10 hemolysis hemolysis NN cord-010119-t1x9gknd 9160 11 in in IN cord-010119-t1x9gknd 9160 12 WAIHA WAIHA NNP cord-010119-t1x9gknd 9160 13 patients patient NNS cord-010119-t1x9gknd 9160 14 , , , cord-010119-t1x9gknd 9160 15 we -PRON- PRP cord-010119-t1x9gknd 9160 16 investigated investigate VBD cord-010119-t1x9gknd 9160 17 the the DT cord-010119-t1x9gknd 9160 18 post post JJ cord-010119-t1x9gknd 9160 19 - - JJ cord-010119-t1x9gknd 9160 20 transfusion transfusion JJ cord-010119-t1x9gknd 9160 21 ( ( -LRB- cord-010119-t1x9gknd 9160 22 post post JJ cord-010119-t1x9gknd 9160 23 - - JJ cord-010119-t1x9gknd 9160 24 tfn tfn JJ cord-010119-t1x9gknd 9160 25 ) ) -RRB- cord-010119-t1x9gknd 9160 26 hematocrit hematocrit NN cord-010119-t1x9gknd 9160 27 ( ( -LRB- cord-010119-t1x9gknd 9160 28 Hct hct NN cord-010119-t1x9gknd 9160 29 ) ) -RRB- cord-010119-t1x9gknd 9160 30 change change NN cord-010119-t1x9gknd 9160 31 in in IN cord-010119-t1x9gknd 9160 32 WAIHA WAIHA NNP cord-010119-t1x9gknd 9160 33 patients patient NNS cord-010119-t1x9gknd 9160 34 who who WP cord-010119-t1x9gknd 9160 35 were be VBD cord-010119-t1x9gknd 9160 36 transfused transfuse VBN cord-010119-t1x9gknd 9160 37 compatible compatible JJ cord-010119-t1x9gknd 9160 38 RBCs rbc NNS cord-010119-t1x9gknd 9160 39 compared compare VBN cord-010119-t1x9gknd 9160 40 to to IN cord-010119-t1x9gknd 9160 41 those those DT cord-010119-t1x9gknd 9160 42 who who WP cord-010119-t1x9gknd 9160 43 received receive VBD cord-010119-t1x9gknd 9160 44 LI LI NNP cord-010119-t1x9gknd 9160 45 blood blood NN cord-010119-t1x9gknd 9160 46 . . . cord-010119-t1x9gknd 9161 1 We -PRON- PRP cord-010119-t1x9gknd 9161 2 further further RB cord-010119-t1x9gknd 9161 3 hypothesized hypothesize VBD cord-010119-t1x9gknd 9161 4 that that IN cord-010119-t1x9gknd 9161 5 a a DT cord-010119-t1x9gknd 9161 6 post post JJ cord-010119-t1x9gknd 9161 7 - - JJ cord-010119-t1x9gknd 9161 8 tfn tfn JJ cord-010119-t1x9gknd 9161 9 Hct Hct NNP cord-010119-t1x9gknd 9161 10 would would MD cord-010119-t1x9gknd 9161 11 be be VB cord-010119-t1x9gknd 9161 12 inversely inversely RB cord-010119-t1x9gknd 9161 13 related relate VBN cord-010119-t1x9gknd 9161 14 to to IN cord-010119-t1x9gknd 9161 15 the the DT cord-010119-t1x9gknd 9161 16 degree degree NN cord-010119-t1x9gknd 9161 17 of of IN cord-010119-t1x9gknd 9161 18 AHG AHG NNP cord-010119-t1x9gknd 9161 19 - - HYPH cord-010119-t1x9gknd 9161 20 phase phase NN cord-010119-t1x9gknd 9161 21 incompatibility incompatibility NN cord-010119-t1x9gknd 9161 22 . . . cord-010119-t1x9gknd 9162 1 Study Study NNP cord-010119-t1x9gknd 9162 2 Design Design NNP cord-010119-t1x9gknd 9162 3 / / SYM cord-010119-t1x9gknd 9162 4 Method method NN cord-010119-t1x9gknd 9162 5 : : : cord-010119-t1x9gknd 9162 6 We -PRON- PRP cord-010119-t1x9gknd 9162 7 reviewed review VBD cord-010119-t1x9gknd 9162 8 all all DT cord-010119-t1x9gknd 9162 9 transfusions transfusion NNS cord-010119-t1x9gknd 9162 10 to to IN cord-010119-t1x9gknd 9162 11 patients patient NNS cord-010119-t1x9gknd 9162 12 in in IN cord-010119-t1x9gknd 9162 13 our -PRON- PRP$ cord-010119-t1x9gknd 9162 14 quaternary quaternary JJ cord-010119-t1x9gknd 9162 15 - - HYPH cord-010119-t1x9gknd 9162 16 care care NN cord-010119-t1x9gknd 9162 17 hospital hospital NN cord-010119-t1x9gknd 9162 18 with with IN cord-010119-t1x9gknd 9162 19 a a DT cord-010119-t1x9gknd 9162 20 history history NN cord-010119-t1x9gknd 9162 21 of of IN cord-010119-t1x9gknd 9162 22 WAIHA WAIHA NNP cord-010119-t1x9gknd 9162 23 from from IN cord-010119-t1x9gknd 9162 24 October October NNP cord-010119-t1x9gknd 9162 25 2015 2015 CD cord-010119-t1x9gknd 9162 26 to to IN cord-010119-t1x9gknd 9162 27 March March NNP cord-010119-t1x9gknd 9162 28 2017 2017 CD cord-010119-t1x9gknd 9162 29 . . . cord-010119-t1x9gknd 9163 1 Patient Patient NNP cord-010119-t1x9gknd 9163 2 Hcts Hcts NNP cord-010119-t1x9gknd 9163 3 were be VBD cord-010119-t1x9gknd 9163 4 ordered order VBN cord-010119-t1x9gknd 9163 5 by by IN cord-010119-t1x9gknd 9163 6 prescribing prescribe VBG cord-010119-t1x9gknd 9163 7 physicians physician NNS cord-010119-t1x9gknd 9163 8 for for IN cord-010119-t1x9gknd 9163 9 clinical clinical JJ cord-010119-t1x9gknd 9163 10 purposes purpose NNS cord-010119-t1x9gknd 9163 11 . . . cord-010119-t1x9gknd 9164 1 A a DT cord-010119-t1x9gknd 9164 2 transfusion transfusion NN cord-010119-t1x9gknd 9164 3 episode episode NN cord-010119-t1x9gknd 9164 4 was be VBD cord-010119-t1x9gknd 9164 5 defined define VBN cord-010119-t1x9gknd 9164 6 as as IN cord-010119-t1x9gknd 9164 7 all all DT cord-010119-t1x9gknd 9164 8 units unit NNS cord-010119-t1x9gknd 9164 9 released release VBN cord-010119-t1x9gknd 9164 10 in in IN cord-010119-t1x9gknd 9164 11 the the DT cord-010119-t1x9gknd 9164 12 interval interval NN cord-010119-t1x9gknd 9164 13 before before IN cord-010119-t1x9gknd 9164 14 a a DT cord-010119-t1x9gknd 9164 15 post post JJ cord-010119-t1x9gknd 9164 16 - - JJ cord-010119-t1x9gknd 9164 17 tfn tfn NNP cord-010119-t1x9gknd 9164 18 CBC CBC NNP cord-010119-t1x9gknd 9164 19 . . . cord-010119-t1x9gknd 9165 1 AHG AHG NNP cord-010119-t1x9gknd 9165 2 - - HYPH cord-010119-t1x9gknd 9165 3 phase phase NN cord-010119-t1x9gknd 9165 4 crossmatch crossmatch NN cord-010119-t1x9gknd 9165 5 was be VBD cord-010119-t1x9gknd 9165 6 tube tube NN cord-010119-t1x9gknd 9165 7 tested test VBN cord-010119-t1x9gknd 9165 8 in in IN cord-010119-t1x9gknd 9165 9 saline saline NN cord-010119-t1x9gknd 9165 10 per per IN cord-010119-t1x9gknd 9165 11 clinical clinical JJ cord-010119-t1x9gknd 9165 12 procedure procedure NN cord-010119-t1x9gknd 9165 13 . . . cord-010119-t1x9gknd 9166 1 Transfusion transfusion NN cord-010119-t1x9gknd 9166 2 medicine medicine NN cord-010119-t1x9gknd 9166 3 physicians physician NNS cord-010119-t1x9gknd 9166 4 determined determine VBD cord-010119-t1x9gknd 9166 5 the the DT cord-010119-t1x9gknd 9166 6 release release NN cord-010119-t1x9gknd 9166 7 of of IN cord-010119-t1x9gknd 9166 8 least least JJS cord-010119-t1x9gknd 9166 9 - - HYPH cord-010119-t1x9gknd 9166 10 incompatible incompatible JJ cord-010119-t1x9gknd 9166 11 units unit NNS cord-010119-t1x9gknd 9166 12 . . . cord-010119-t1x9gknd 9167 1 Statistical statistical JJ cord-010119-t1x9gknd 9167 2 tests test NNS cord-010119-t1x9gknd 9167 3 were be VBD cord-010119-t1x9gknd 9167 4 performed perform VBN cord-010119-t1x9gknd 9167 5 with with IN cord-010119-t1x9gknd 9167 6 STATCALC STATCALC NNP cord-010119-t1x9gknd 9167 7 ( ( -LRB- cord-010119-t1x9gknd 9167 8 EpiInfo EpiInfo NNP cord-010119-t1x9gknd 9167 9 , , , cord-010119-t1x9gknd 9167 10 CDC CDC NNP cord-010119-t1x9gknd 9167 11 ) ) -RRB- cord-010119-t1x9gknd 9167 12 and and CC cord-010119-t1x9gknd 9167 13 www.socscistatistics.com www.socscistatistics.com ADD cord-010119-t1x9gknd 9167 14 . . . cord-010119-t1x9gknd 9168 1 Results/ Results/ . cord-010119-t1x9gknd 9169 1 Finding find VBG cord-010119-t1x9gknd 9169 2 : : : cord-010119-t1x9gknd 9169 3 There there EX cord-010119-t1x9gknd 9169 4 were be VBD cord-010119-t1x9gknd 9169 5 139 139 CD cord-010119-t1x9gknd 9169 6 RBC RBC NNP cord-010119-t1x9gknd 9169 7 products product NNS cord-010119-t1x9gknd 9169 8 transfused transfuse VBN cord-010119-t1x9gknd 9169 9 to to IN cord-010119-t1x9gknd 9169 10 40 40 CD cord-010119-t1x9gknd 9169 11 WAIHA WAIHA NNP cord-010119-t1x9gknd 9169 12 patients patient NNS cord-010119-t1x9gknd 9169 13 . . . cord-010119-t1x9gknd 9170 1 Twenty twenty CD cord-010119-t1x9gknd 9170 2 - - HYPH cord-010119-t1x9gknd 9170 3 three three CD cord-010119-t1x9gknd 9170 4 ( ( -LRB- cord-010119-t1x9gknd 9170 5 57.5 57.5 CD cord-010119-t1x9gknd 9170 6 % % NN cord-010119-t1x9gknd 9170 7 ) ) -RRB- cord-010119-t1x9gknd 9170 8 patients patient NNS cord-010119-t1x9gknd 9170 9 received receive VBD cord-010119-t1x9gknd 9170 10 at at IN cord-010119-t1x9gknd 9170 11 least least JJS cord-010119-t1x9gknd 9170 12 1 1 CD cord-010119-t1x9gknd 9170 13 incompatible incompatible JJ cord-010119-t1x9gknd 9170 14 unit unit NN cord-010119-t1x9gknd 9170 15 . . . cord-010119-t1x9gknd 9171 1 The the DT cord-010119-t1x9gknd 9171 2 mean mean JJ cord-010119-t1x9gknd 9171 3 age age NN cord-010119-t1x9gknd 9171 4 was be VBD cord-010119-t1x9gknd 9171 5 51.4 51.4 CD cord-010119-t1x9gknd 9171 6 years year NNS cord-010119-t1x9gknd 9172 1 ( ( -LRB- cord-010119-t1x9gknd 9172 2 range range NNP cord-010119-t1x9gknd 9172 3 4 4 CD cord-010119-t1x9gknd 9172 4 - - SYM cord-010119-t1x9gknd 9172 5 93 93 CD cord-010119-t1x9gknd 9172 6 yrs yrs NN cord-010119-t1x9gknd 9172 7 ) ) -RRB- cord-010119-t1x9gknd 9172 8 with with IN cord-010119-t1x9gknd 9172 9 50 50 CD cord-010119-t1x9gknd 9172 10 % % NN cord-010119-t1x9gknd 9172 11 women woman NNS cord-010119-t1x9gknd 9172 12 . . . cord-010119-t1x9gknd 9173 1 Ethnic ethnic JJ cord-010119-t1x9gknd 9173 2 composition composition NN cord-010119-t1x9gknd 9173 3 was be VBD cord-010119-t1x9gknd 9173 4 55 55 CD cord-010119-t1x9gknd 9173 5 % % NN cord-010119-t1x9gknd 9173 6 African african JJ cord-010119-t1x9gknd 9173 7 - - HYPH cord-010119-t1x9gknd 9173 8 American american JJ cord-010119-t1x9gknd 9173 9 , , , cord-010119-t1x9gknd 9173 10 40 40 CD cord-010119-t1x9gknd 9173 11 % % NN cord-010119-t1x9gknd 9173 12 Caucasian caucasian JJ cord-010119-t1x9gknd 9173 13 , , , cord-010119-t1x9gknd 9173 14 and and CC cord-010119-t1x9gknd 9173 15 5 5 CD cord-010119-t1x9gknd 9173 16 % % NN cord-010119-t1x9gknd 9173 17 patients patient NNS cord-010119-t1x9gknd 9173 18 of of IN cord-010119-t1x9gknd 9173 19 mixed mixed JJ cord-010119-t1x9gknd 9173 20 / / SYM cord-010119-t1x9gknd 9173 21 other other JJ cord-010119-t1x9gknd 9173 22 ethnicity ethnicity NN cord-010119-t1x9gknd 9173 23 . . . cord-010119-t1x9gknd 9174 1 One one CD cord-010119-t1x9gknd 9174 2 hundred hundred CD cord-010119-t1x9gknd 9174 3 fourteen fourteen CD cord-010119-t1x9gknd 9174 4 ( ( -LRB- cord-010119-t1x9gknd 9174 5 82 82 CD cord-010119-t1x9gknd 9174 6 % % NN cord-010119-t1x9gknd 9174 7 ) ) -RRB- cord-010119-t1x9gknd 9174 8 of of IN cord-010119-t1x9gknd 9174 9 these these DT cord-010119-t1x9gknd 9174 10 products product NNS cord-010119-t1x9gknd 9174 11 were be VBD cord-010119-t1x9gknd 9174 12 released release VBN cord-010119-t1x9gknd 9174 13 as as IN cord-010119-t1x9gknd 9174 14 LI LI NNP cord-010119-t1x9gknd 9174 15 products product NNS cord-010119-t1x9gknd 9174 16 and and CC cord-010119-t1x9gknd 9174 17 25 25 CD cord-010119-t1x9gknd 9174 18 ( ( -LRB- cord-010119-t1x9gknd 9174 19 18 18 CD cord-010119-t1x9gknd 9174 20 % % NN cord-010119-t1x9gknd 9174 21 ) ) -RRB- cord-010119-t1x9gknd 9174 22 were be VBD cord-010119-t1x9gknd 9174 23 compatible compatible JJ cord-010119-t1x9gknd 9174 24 . . . cord-010119-t1x9gknd 9175 1 Ninetythree Ninetythree NNP cord-010119-t1x9gknd 9175 2 ( ( -LRB- cord-010119-t1x9gknd 9175 3 81.6 81.6 CD cord-010119-t1x9gknd 9175 4 % % NN cord-010119-t1x9gknd 9175 5 ) ) -RRB- cord-010119-t1x9gknd 9175 6 of of IN cord-010119-t1x9gknd 9175 7 the the DT cord-010119-t1x9gknd 9175 8 LI LI NNP cord-010119-t1x9gknd 9175 9 product product NN cord-010119-t1x9gknd 9175 10 transfusions transfusion NNS cord-010119-t1x9gknd 9175 11 had have VBD cord-010119-t1x9gknd 9175 12 a a DT cord-010119-t1x9gknd 9175 13 post post JJ cord-010119-t1x9gknd 9175 14 - - JJ cord-010119-t1x9gknd 9175 15 tfn tfn JJ cord-010119-t1x9gknd 9175 16 Hct Hct NNP cord-010119-t1x9gknd 9175 17 change change NN cord-010119-t1x9gknd 9175 18 of of IN cord-010119-t1x9gknd 9175 19 <3 <3 CD cord-010119-t1x9gknd 9175 20 % % NN cord-010119-t1x9gknd 9175 21 whereas whereas IN cord-010119-t1x9gknd 9175 22 only only RB cord-010119-t1x9gknd 9175 23 14 14 CD cord-010119-t1x9gknd 9175 24 ( ( -LRB- cord-010119-t1x9gknd 9175 25 56 56 CD cord-010119-t1x9gknd 9175 26 % % NN cord-010119-t1x9gknd 9175 27 ) ) -RRB- cord-010119-t1x9gknd 9175 28 of of IN cord-010119-t1x9gknd 9175 29 the the DT cord-010119-t1x9gknd 9175 30 compatible compatible JJ cord-010119-t1x9gknd 9175 31 product product NN cord-010119-t1x9gknd 9175 32 transfusions transfusion NNS cord-010119-t1x9gknd 9175 33 resulted result VBD cord-010119-t1x9gknd 9175 34 in in IN cord-010119-t1x9gknd 9175 35 a a DT cord-010119-t1x9gknd 9175 36 post post JJ cord-010119-t1x9gknd 9175 37 - - JJ cord-010119-t1x9gknd 9175 38 tfn tfn JJ cord-010119-t1x9gknd 9175 39 Hct Hct NNP cord-010119-t1x9gknd 9175 40 change change NN cord-010119-t1x9gknd 9175 41 of of IN cord-010119-t1x9gknd 9175 42 <3 <3 CD cord-010119-t1x9gknd 9175 43 % % NN cord-010119-t1x9gknd 9175 44 ( ( -LRB- cord-010119-t1x9gknd 9175 45 p50.0092 p50.0092 UH cord-010119-t1x9gknd 9175 46 , , , cord-010119-t1x9gknd 9175 47 v v LS cord-010119-t1x9gknd 9175 48 2 2 CD cord-010119-t1x9gknd 9175 49 ( ( -LRB- cord-010119-t1x9gknd 9175 50 1 1 CD cord-010119-t1x9gknd 9175 51 ) ) -RRB- cord-010119-t1x9gknd 9175 52 , , , cord-010119-t1x9gknd 9175 53 exact exact JJ cord-010119-t1x9gknd 9175 54 methods method NNS cord-010119-t1x9gknd 9175 55 ) ) -RRB- cord-010119-t1x9gknd 9175 56 . . . cord-010119-t1x9gknd 9176 1 The the DT cord-010119-t1x9gknd 9176 2 mean mean NN cord-010119-t1x9gknd 9176 3 Hct Hct NNP cord-010119-t1x9gknd 9176 4 increase increase NN cord-010119-t1x9gknd 9176 5 in in IN cord-010119-t1x9gknd 9176 6 the the DT cord-010119-t1x9gknd 9176 7 compatible compatible JJ cord-010119-t1x9gknd 9176 8 group group NN cord-010119-t1x9gknd 9176 9 was be VBD cord-010119-t1x9gknd 9176 10 1.83 1.83 CD cord-010119-t1x9gknd 9176 11 % % NN cord-010119-t1x9gknd 9176 12 per per IN cord-010119-t1x9gknd 9176 13 unit unit NN cord-010119-t1x9gknd 9176 14 vs. vs. IN cord-010119-t1x9gknd 9176 15 a a DT cord-010119-t1x9gknd 9176 16 slightly slightly RB cord-010119-t1x9gknd 9176 17 lesser less JJR cord-010119-t1x9gknd 9176 18 per per IN cord-010119-t1x9gknd 9176 19 - - HYPH cord-010119-t1x9gknd 9176 20 unit unit NN cord-010119-t1x9gknd 9176 21 increase increase NN cord-010119-t1x9gknd 9176 22 of of IN cord-010119-t1x9gknd 9176 23 1.71 1.71 CD cord-010119-t1x9gknd 9176 24 % % NN cord-010119-t1x9gknd 9176 25 in in IN cord-010119-t1x9gknd 9176 26 the the DT cord-010119-t1x9gknd 9176 27 LI LI NNP cord-010119-t1x9gknd 9176 28 group group NN cord-010119-t1x9gknd 9176 29 ( ( -LRB- cord-010119-t1x9gknd 9176 30 p50.82 p50.82 NN cord-010119-t1x9gknd 9176 31 , , , cord-010119-t1x9gknd 9176 32 t t NN cord-010119-t1x9gknd 9176 33 - - HYPH cord-010119-t1x9gknd 9176 34 test test NN cord-010119-t1x9gknd 9176 35 , , , cord-010119-t1x9gknd 9176 36 2-tailed 2-tailed CD cord-010119-t1x9gknd 9176 37 ) ) -RRB- cord-010119-t1x9gknd 9177 1 Within within IN cord-010119-t1x9gknd 9177 2 the the DT cord-010119-t1x9gknd 9177 3 LI LI NNP cord-010119-t1x9gknd 9177 4 group group NN cord-010119-t1x9gknd 9177 5 , , , cord-010119-t1x9gknd 9177 6 there there EX cord-010119-t1x9gknd 9177 7 was be VBD cord-010119-t1x9gknd 9177 8 no no DT cord-010119-t1x9gknd 9177 9 difference difference NN cord-010119-t1x9gknd 9177 10 in in IN cord-010119-t1x9gknd 9177 11 the the DT cord-010119-t1x9gknd 9177 12 per per IN cord-010119-t1x9gknd 9177 13 - - HYPH cord-010119-t1x9gknd 9177 14 unit unit NN cord-010119-t1x9gknd 9177 15 Hct Hct NNP cord-010119-t1x9gknd 9177 16 change change NN cord-010119-t1x9gknd 9177 17 according accord VBG cord-010119-t1x9gknd 9177 18 to to IN cord-010119-t1x9gknd 9177 19 strength strength NN cord-010119-t1x9gknd 9177 20 of of IN cord-010119-t1x9gknd 9177 21 incompatibility incompatibility NN cord-010119-t1x9gknd 9177 22 ( ( -LRB- cord-010119-t1x9gknd 9177 23 Table table NN cord-010119-t1x9gknd 9177 24 ) ) -RRB- cord-010119-t1x9gknd 9177 25 . . . cord-010119-t1x9gknd 9178 1 Strength strength NN cord-010119-t1x9gknd 9178 2 of of IN cord-010119-t1x9gknd 9178 3 AHG AHG NNP cord-010119-t1x9gknd 9178 4 incompatibility incompatibility NN cord-010119-t1x9gknd 9178 5 was be VBD cord-010119-t1x9gknd 9178 6 not not RB cord-010119-t1x9gknd 9178 7 available available JJ cord-010119-t1x9gknd 9178 8 for for IN cord-010119-t1x9gknd 9178 9 12 12 CD cord-010119-t1x9gknd 9178 10 units unit NNS cord-010119-t1x9gknd 9178 11 . . . cord-010119-t1x9gknd 9179 1 Units unit NNS cord-010119-t1x9gknd 9179 2 that that WDT cord-010119-t1x9gknd 9179 3 were be VBD cord-010119-t1x9gknd 9179 4 31 31 CD cord-010119-t1x9gknd 9179 5 incompatible incompatible JJ cord-010119-t1x9gknd 9179 6 had have VBD cord-010119-t1x9gknd 9179 7 a a DT cord-010119-t1x9gknd 9179 8 lower low JJR cord-010119-t1x9gknd 9179 9 mean mean JJ cord-010119-t1x9gknd 9179 10 post post JJ cord-010119-t1x9gknd 9179 11 - - JJ cord-010119-t1x9gknd 9179 12 tfn tfn JJ cord-010119-t1x9gknd 9179 13 Hct Hct NNP cord-010119-t1x9gknd 9179 14 rise rise NN cord-010119-t1x9gknd 9179 15 compared compare VBN cord-010119-t1x9gknd 9179 16 to to IN cord-010119-t1x9gknd 9179 17 all all DT cord-010119-t1x9gknd 9179 18 other other JJ cord-010119-t1x9gknd 9179 19 LI LI NNP cord-010119-t1x9gknd 9179 20 units unit NNS cord-010119-t1x9gknd 9179 21 ( ( -LRB- cord-010119-t1x9gknd 9179 22 1.49 1.49 CD cord-010119-t1x9gknd 9179 23 % % NN cord-010119-t1x9gknd 9179 24 vs. vs. IN cord-010119-t1x9gknd 9179 25 2.15 2.15 CD cord-010119-t1x9gknd 9179 26 % % NN cord-010119-t1x9gknd 9179 27 ) ) -RRB- cord-010119-t1x9gknd 9179 28 ; ; : cord-010119-t1x9gknd 9179 29 however however RB cord-010119-t1x9gknd 9179 30 , , , cord-010119-t1x9gknd 9179 31 this this DT cord-010119-t1x9gknd 9179 32 difference difference NN cord-010119-t1x9gknd 9179 33 was be VBD cord-010119-t1x9gknd 9179 34 not not RB cord-010119-t1x9gknd 9179 35 statistically statistically RB cord-010119-t1x9gknd 9179 36 significant significant JJ cord-010119-t1x9gknd 9179 37 ( ( -LRB- cord-010119-t1x9gknd 9179 38 p50.38 p50.38 NN cord-010119-t1x9gknd 9179 39 ) ) -RRB- cord-010119-t1x9gknd 9179 40 . . . cord-010119-t1x9gknd 9180 1 Conclusion conclusion NN cord-010119-t1x9gknd 9180 2 : : : cord-010119-t1x9gknd 9181 1 The the DT cord-010119-t1x9gknd 9181 2 post post JJ cord-010119-t1x9gknd 9181 3 - - JJ cord-010119-t1x9gknd 9181 4 tfn tfn JJ cord-010119-t1x9gknd 9181 5 Hct Hct NNP cord-010119-t1x9gknd 9181 6 change change NN cord-010119-t1x9gknd 9181 7 for for IN cord-010119-t1x9gknd 9181 8 transfusions transfusion NNS cord-010119-t1x9gknd 9181 9 of of IN cord-010119-t1x9gknd 9181 10 LI LI NNP cord-010119-t1x9gknd 9181 11 units unit NNS cord-010119-t1x9gknd 9181 12 to to IN cord-010119-t1x9gknd 9181 13 patients patient NNS cord-010119-t1x9gknd 9181 14 with with IN cord-010119-t1x9gknd 9181 15 WAIHA WAIHA NNP cord-010119-t1x9gknd 9181 16 was be VBD cord-010119-t1x9gknd 9181 17 less less JJR cord-010119-t1x9gknd 9181 18 than than IN cord-010119-t1x9gknd 9181 19 the the DT cord-010119-t1x9gknd 9181 20 expected expected JJ cord-010119-t1x9gknd 9181 21 3 3 CD cord-010119-t1x9gknd 9181 22 % % NN cord-010119-t1x9gknd 9181 23 per per IN cord-010119-t1x9gknd 9181 24 unit unit NN cord-010119-t1x9gknd 9181 25 more more RBR cord-010119-t1x9gknd 9181 26 frequently frequently RB cord-010119-t1x9gknd 9181 27 than than IN cord-010119-t1x9gknd 9181 28 it -PRON- PRP cord-010119-t1x9gknd 9181 29 was be VBD cord-010119-t1x9gknd 9181 30 for for IN cord-010119-t1x9gknd 9181 31 WAIHA WAIHA NNP cord-010119-t1x9gknd 9181 32 patients patient NNS cord-010119-t1x9gknd 9181 33 who who WP cord-010119-t1x9gknd 9181 34 received receive VBD cord-010119-t1x9gknd 9181 35 compatible compatible JJ cord-010119-t1x9gknd 9181 36 products product NNS cord-010119-t1x9gknd 9181 37 ( ( -LRB- cord-010119-t1x9gknd 9181 38 81.6 81.6 CD cord-010119-t1x9gknd 9181 39 % % NN cord-010119-t1x9gknd 9181 40 vs. vs. NN cord-010119-t1x9gknd 9181 41 56 56 CD cord-010119-t1x9gknd 9181 42 % % NN cord-010119-t1x9gknd 9181 43 ) ) -RRB- cord-010119-t1x9gknd 9181 44 . . . cord-010119-t1x9gknd 9182 1 However however RB cord-010119-t1x9gknd 9182 2 , , , cord-010119-t1x9gknd 9182 3 likely likely RB cord-010119-t1x9gknd 9182 4 due due IN cord-010119-t1x9gknd 9182 5 to to IN cord-010119-t1x9gknd 9182 6 our -PRON- PRP$ cord-010119-t1x9gknd 9182 7 small small JJ cord-010119-t1x9gknd 9182 8 sample sample NN cord-010119-t1x9gknd 9182 9 size size NN cord-010119-t1x9gknd 9182 10 , , , cord-010119-t1x9gknd 9182 11 the the DT cord-010119-t1x9gknd 9182 12 mean mean JJ cord-010119-t1x9gknd 9182 13 differences difference NNS cord-010119-t1x9gknd 9182 14 were be VBD cord-010119-t1x9gknd 9182 15 not not RB cord-010119-t1x9gknd 9182 16 statistically statistically RB cord-010119-t1x9gknd 9182 17 significant significant JJ cord-010119-t1x9gknd 9182 18 . . . cord-010119-t1x9gknd 9183 1 Interestingly interestingly RB cord-010119-t1x9gknd 9183 2 , , , cord-010119-t1x9gknd 9183 3 there there EX cord-010119-t1x9gknd 9183 4 was be VBD cord-010119-t1x9gknd 9183 5 no no DT cord-010119-t1x9gknd 9183 6 difference difference NN cord-010119-t1x9gknd 9183 7 in in IN cord-010119-t1x9gknd 9183 8 the the DT cord-010119-t1x9gknd 9183 9 per per IN cord-010119-t1x9gknd 9183 10 - - HYPH cord-010119-t1x9gknd 9183 11 unit unit NN cord-010119-t1x9gknd 9183 12 post post NN cord-010119-t1x9gknd 9183 13 - - JJ cord-010119-t1x9gknd 9183 14 tfn tfn JJ cord-010119-t1x9gknd 9183 15 Hct Hct NNP cord-010119-t1x9gknd 9183 16 according accord VBG cord-010119-t1x9gknd 9183 17 to to IN cord-010119-t1x9gknd 9183 18 differing differ VBG cord-010119-t1x9gknd 9183 19 strengths strength NNS cord-010119-t1x9gknd 9183 20 of of IN cord-010119-t1x9gknd 9183 21 incompatibility incompatibility NN cord-010119-t1x9gknd 9183 22 in in IN cord-010119-t1x9gknd 9183 23 our -PRON- PRP$ cord-010119-t1x9gknd 9183 24 sample sample NN cord-010119-t1x9gknd 9183 25 , , , cord-010119-t1x9gknd 9183 26 although although IN cord-010119-t1x9gknd 9183 27 the the DT cord-010119-t1x9gknd 9183 28 mean mean JJ cord-010119-t1x9gknd 9183 29 increase increase NN cord-010119-t1x9gknd 9183 30 for for IN cord-010119-t1x9gknd 9183 31 the the DT cord-010119-t1x9gknd 9183 32 31 31 CD cord-010119-t1x9gknd 9183 33 LI LI NNP cord-010119-t1x9gknd 9183 34 products product NNS cord-010119-t1x9gknd 9183 35 was be VBD cord-010119-t1x9gknd 9183 36 less less JJR cord-010119-t1x9gknd 9183 37 than than IN cord-010119-t1x9gknd 9183 38 all all DT cord-010119-t1x9gknd 9183 39 other other JJ cord-010119-t1x9gknd 9183 40 LI LI NNP cord-010119-t1x9gknd 9183 41 products product NNS cord-010119-t1x9gknd 9183 42 combined combine VBN cord-010119-t1x9gknd 9183 43 . . . cord-010119-t1x9gknd 9184 1 The the DT cord-010119-t1x9gknd 9184 2 increase increase NN cord-010119-t1x9gknd 9184 3 was be VBD cord-010119-t1x9gknd 9184 4 unexpectedly unexpectedly RB cord-010119-t1x9gknd 9184 5 low low JJ cord-010119-t1x9gknd 9184 6 for for IN cord-010119-t1x9gknd 9184 7 weaklyincompatible weaklyincompatible JJ cord-010119-t1x9gknd 9184 8 units unit NNS cord-010119-t1x9gknd 9184 9 , , , cord-010119-t1x9gknd 9184 10 which which WDT cord-010119-t1x9gknd 9184 11 we -PRON- PRP cord-010119-t1x9gknd 9184 12 are be VBP cord-010119-t1x9gknd 9184 13 further further RB cord-010119-t1x9gknd 9184 14 studying study VBG cord-010119-t1x9gknd 9184 15 . . . cord-010119-t1x9gknd 9185 1 Future future JJ cord-010119-t1x9gknd 9185 2 work work NN cord-010119-t1x9gknd 9185 3 includes include VBZ cord-010119-t1x9gknd 9185 4 consideration consideration NN cord-010119-t1x9gknd 9185 5 of of IN cord-010119-t1x9gknd 9185 6 inpatient inpatient JJ cord-010119-t1x9gknd 9185 7 vs. vs. FW cord-010119-t1x9gknd 9185 8 outpatient outpatient JJ cord-010119-t1x9gknd 9185 9 clinical clinical JJ cord-010119-t1x9gknd 9185 10 status status NN cord-010119-t1x9gknd 9185 11 , , , cord-010119-t1x9gknd 9185 12 effect effect NN cord-010119-t1x9gknd 9185 13 of of IN cord-010119-t1x9gknd 9185 14 co co JJ cord-010119-t1x9gknd 9185 15 - - JJ cord-010119-t1x9gknd 9185 16 incident incident NN cord-010119-t1x9gknd 9185 17 alloantibodies alloantibody NNS cord-010119-t1x9gknd 9185 18 , , , cord-010119-t1x9gknd 9185 19 comorbidities comorbiditie NNS cord-010119-t1x9gknd 9185 20 , , , cord-010119-t1x9gknd 9185 21 and and CC cord-010119-t1x9gknd 9185 22 medications medication NNS cord-010119-t1x9gknd 9185 23 . . . cord-010119-t1x9gknd 9186 1 transfusion transfusion NN cord-010119-t1x9gknd 9186 2 management management NN cord-010119-t1x9gknd 9186 3 was be VBD cord-010119-t1x9gknd 9186 4 summarised summarise VBN cord-010119-t1x9gknd 9186 5 by by IN cord-010119-t1x9gknd 9186 6 individual individual JJ cord-010119-t1x9gknd 9186 7 hospital hospital NN cord-010119-t1x9gknd 9186 8 , , , cord-010119-t1x9gknd 9186 9 type type NN cord-010119-t1x9gknd 9186 10 and and CC cord-010119-t1x9gknd 9186 11 total total JJ cord-010119-t1x9gknd 9186 12 cases case NNS cord-010119-t1x9gknd 9186 13 . . . cord-010119-t1x9gknd 9187 1 In in IN cord-010119-t1x9gknd 9187 2 - - HYPH cord-010119-t1x9gknd 9187 3 hospital hospital NN cord-010119-t1x9gknd 9187 4 mortality mortality NN cord-010119-t1x9gknd 9187 5 ( ( -LRB- cord-010119-t1x9gknd 9187 6 adjusted adjust VBN cord-010119-t1x9gknd 9187 7 for for IN cord-010119-t1x9gknd 9187 8 age age NN cord-010119-t1x9gknd 9187 9 , , , cord-010119-t1x9gknd 9187 10 sex sex NN cord-010119-t1x9gknd 9187 11 , , , cord-010119-t1x9gknd 9187 12 comorbidity comorbidity NN cord-010119-t1x9gknd 9187 13 , , , cord-010119-t1x9gknd 9187 14 bleeding bleed VBG cord-010119-t1x9gknd 9187 15 context context NN cord-010119-t1x9gknd 9187 16 and and CC cord-010119-t1x9gknd 9187 17 number number NN cord-010119-t1x9gknd 9187 18 of of IN cord-010119-t1x9gknd 9187 19 RBCs rbc NNS cord-010119-t1x9gknd 9187 20 in in IN cord-010119-t1x9gknd 9187 21 the the DT cord-010119-t1x9gknd 9187 22 first first JJ cord-010119-t1x9gknd 9187 23 4-hours 4-hours CD cord-010119-t1x9gknd 9187 24 from from IN cord-010119-t1x9gknd 9187 25 MT MT NNP cord-010119-t1x9gknd 9187 26 onset onset NN cord-010119-t1x9gknd 9187 27 ) ) -RRB- cord-010119-t1x9gknd 9187 28 was be VBD cord-010119-t1x9gknd 9187 29 calculated calculate VBN cord-010119-t1x9gknd 9187 30 with with IN cord-010119-t1x9gknd 9187 31 95 95 CD cord-010119-t1x9gknd 9187 32 % % NN cord-010119-t1x9gknd 9187 33 and and CC cord-010119-t1x9gknd 9187 34 99.8 99.8 CD cord-010119-t1x9gknd 9187 35 % % NN cord-010119-t1x9gknd 9187 36 control control NN cord-010119-t1x9gknd 9187 37 limits limit NNS cord-010119-t1x9gknd 9187 38 to to TO cord-010119-t1x9gknd 9187 39 indicate indicate VB cord-010119-t1x9gknd 9187 40 potential potential JJ cord-010119-t1x9gknd 9187 41 outliers outlier NNS cord-010119-t1x9gknd 9187 42 . . . cord-010119-t1x9gknd 9188 1 Data datum NNS cord-010119-t1x9gknd 9188 2 were be VBD cord-010119-t1x9gknd 9188 3 analyzed analyze VBN cord-010119-t1x9gknd 9188 4 using use VBG cord-010119-t1x9gknd 9188 5 statistical statistical JJ cord-010119-t1x9gknd 9188 6 software software NN cord-010119-t1x9gknd 9188 7 ( ( -LRB- cord-010119-t1x9gknd 9188 8 Stata Stata NNP cord-010119-t1x9gknd 9188 9 ) ) -RRB- cord-010119-t1x9gknd 9188 10 . . . cord-010119-t1x9gknd 9189 1 Results/ Results/ . cord-010119-t1x9gknd 9190 1 Finding find VBG cord-010119-t1x9gknd 9190 2 : : : cord-010119-t1x9gknd 9190 3 There there EX cord-010119-t1x9gknd 9190 4 were be VBD cord-010119-t1x9gknd 9190 5 5482 5482 CD cord-010119-t1x9gknd 9190 6 MT MT NNP cord-010119-t1x9gknd 9190 7 cases case NNS cord-010119-t1x9gknd 9190 8 from from IN cord-010119-t1x9gknd 9190 9 25 25 CD cord-010119-t1x9gknd 9190 10 hospitals hospital NNS cord-010119-t1x9gknd 9190 11 ( ( -LRB- cord-010119-t1x9gknd 9190 12 17 17 CD cord-010119-t1x9gknd 9190 13 tertiarylevel tertiarylevel NN cord-010119-t1x9gknd 9190 14 , , , cord-010119-t1x9gknd 9190 15 6 6 CD cord-010119-t1x9gknd 9190 16 smaller small JJR cord-010119-t1x9gknd 9190 17 / / SYM cord-010119-t1x9gknd 9190 18 medium medium JJ cord-010119-t1x9gknd 9190 19 sized sized JJ cord-010119-t1x9gknd 9190 20 acute acute JJ cord-010119-t1x9gknd 9190 21 - - HYPH cord-010119-t1x9gknd 9190 22 care care NN cord-010119-t1x9gknd 9190 23 and and CC cord-010119-t1x9gknd 9190 24 2 2 CD cord-010119-t1x9gknd 9190 25 specialist specialist NN cord-010119-t1x9gknd 9190 26 women woman NNS cord-010119-t1x9gknd 9190 27 's 's POS cord-010119-t1x9gknd 9190 28 ) ) -RRB- cord-010119-t1x9gknd 9190 29 . . . cord-010119-t1x9gknd 9191 1 Number number NN cord-010119-t1x9gknd 9191 2 of of IN cord-010119-t1x9gknd 9191 3 MT MT NNP cord-010119-t1x9gknd 9191 4 cases case NNS cord-010119-t1x9gknd 9191 5 per per IN cord-010119-t1x9gknd 9191 6 hospital hospital NN cord-010119-t1x9gknd 9191 7 ranged range VBD cord-010119-t1x9gknd 9191 8 from from IN cord-010119-t1x9gknd 9191 9 5 5 CD cord-010119-t1x9gknd 9191 10 to to IN cord-010119-t1x9gknd 9191 11 721 721 CD cord-010119-t1x9gknd 9191 12 . . . cord-010119-t1x9gknd 9192 1 Patient patient JJ cord-010119-t1x9gknd 9192 2 median median JJ cord-010119-t1x9gknd 9192 3 age age NN cord-010119-t1x9gknd 9192 4 was be VBD cord-010119-t1x9gknd 9192 5 65 65 CD cord-010119-t1x9gknd 9192 6 years year NNS cord-010119-t1x9gknd 9192 7 ( ( -LRB- cord-010119-t1x9gknd 9192 8 IQR IQR NNP cord-010119-t1x9gknd 9192 9 49 49 CD cord-010119-t1x9gknd 9192 10 , , , cord-010119-t1x9gknd 9192 11 76 76 CD cord-010119-t1x9gknd 9192 12 ) ) -RRB- cord-010119-t1x9gknd 9192 13 , , , cord-010119-t1x9gknd 9192 14 62 62 CD cord-010119-t1x9gknd 9192 15 % % NN cord-010119-t1x9gknd 9192 16 were be VBD cord-010119-t1x9gknd 9192 17 male male JJ cord-010119-t1x9gknd 9192 18 and and CC cord-010119-t1x9gknd 9192 19 73 73 CD cord-010119-t1x9gknd 9192 20 % % NN cord-010119-t1x9gknd 9192 21 required require VBN cord-010119-t1x9gknd 9192 22 admission admission NN cord-010119-t1x9gknd 9192 23 to to IN cord-010119-t1x9gknd 9192 24 intensive intensive JJ cord-010119-t1x9gknd 9192 25 care care NN cord-010119-t1x9gknd 9192 26 . . . cord-010119-t1x9gknd 9193 1 The the DT cord-010119-t1x9gknd 9193 2 most most RBS cord-010119-t1x9gknd 9193 3 common common JJ cord-010119-t1x9gknd 9193 4 clinical clinical JJ cord-010119-t1x9gknd 9193 5 groups group NNS cord-010119-t1x9gknd 9193 6 were be VBD cord-010119-t1x9gknd 9193 7 cardiac cardiac JJ cord-010119-t1x9gknd 9193 8 surgery surgery NN cord-010119-t1x9gknd 9193 9 ( ( -LRB- cord-010119-t1x9gknd 9193 10 21 21 CD cord-010119-t1x9gknd 9193 11 % % NN cord-010119-t1x9gknd 9193 12 cases case NNS cord-010119-t1x9gknd 9193 13 ) ) -RRB- cord-010119-t1x9gknd 9193 14 , , , cord-010119-t1x9gknd 9193 15 trauma trauma NN cord-010119-t1x9gknd 9193 16 ( ( -LRB- cord-010119-t1x9gknd 9193 17 20 20 CD cord-010119-t1x9gknd 9193 18 % % NN cord-010119-t1x9gknd 9193 19 ) ) -RRB- cord-010119-t1x9gknd 9193 20 and and CC cord-010119-t1x9gknd 9193 21 gastrointestinal gastrointestinal JJ cord-010119-t1x9gknd 9193 22 hemorrhage hemorrhage NN cord-010119-t1x9gknd 9193 23 ( ( -LRB- cord-010119-t1x9gknd 9193 24 13 13 CD cord-010119-t1x9gknd 9193 25 % % NN cord-010119-t1x9gknd 9193 26 ) ) -RRB- cord-010119-t1x9gknd 9193 27 ; ; : cord-010119-t1x9gknd 9194 1 however however RB cord-010119-t1x9gknd 9194 2 there there EX cord-010119-t1x9gknd 9194 3 was be VBD cord-010119-t1x9gknd 9194 4 marked mark VBN cord-010119-t1x9gknd 9194 5 variation variation NN cord-010119-t1x9gknd 9194 6 between between IN cord-010119-t1x9gknd 9194 7 hospitals hospital NNS cord-010119-t1x9gknd 9194 8 . . . cord-010119-t1x9gknd 9195 1 Ratios ratio NNS cord-010119-t1x9gknd 9195 2 of of IN cord-010119-t1x9gknd 9195 3 transfused transfuse VBN cord-010119-t1x9gknd 9195 4 products product NNS cord-010119-t1x9gknd 9195 5 , , , cord-010119-t1x9gknd 9195 6 analyzed analyze VBD cord-010119-t1x9gknd 9195 7 according accord VBG cord-010119-t1x9gknd 9195 8 to to IN cord-010119-t1x9gknd 9195 9 bleeding bleed VBG cord-010119-t1x9gknd 9195 10 context context NN cord-010119-t1x9gknd 9195 11 , , , cord-010119-t1x9gknd 9195 12 varied varied JJ cord-010119-t1x9gknd 9195 13 between between IN cord-010119-t1x9gknd 9195 14 hospital hospital NN cord-010119-t1x9gknd 9195 15 types type NNS cord-010119-t1x9gknd 9195 16 . . . cord-010119-t1x9gknd 9196 1 The the DT cord-010119-t1x9gknd 9196 2 pooled pool VBN cord-010119-t1x9gknd 9196 3 average average NN cord-010119-t1x9gknd 9196 4 adjusted adjust VBN cord-010119-t1x9gknd 9196 5 in in IN cord-010119-t1x9gknd 9196 6 - - HYPH cord-010119-t1x9gknd 9196 7 hospital hospital NN cord-010119-t1x9gknd 9196 8 mortality mortality NN cord-010119-t1x9gknd 9196 9 for for IN cord-010119-t1x9gknd 9196 10 the the DT cord-010119-t1x9gknd 9196 11 17 17 CD cord-010119-t1x9gknd 9196 12 tertiary tertiary JJ cord-010119-t1x9gknd 9196 13 - - HYPH cord-010119-t1x9gknd 9196 14 level level NN cord-010119-t1x9gknd 9196 15 hospitals hospital NNS cord-010119-t1x9gknd 9197 1 was be VBD cord-010119-t1x9gknd 9197 2 21 21 CD cord-010119-t1x9gknd 9197 3 % % NN cord-010119-t1x9gknd 9197 4 ( ( -LRB- cord-010119-t1x9gknd 9197 5 range range NN cord-010119-t1x9gknd 9197 6 13 13 CD cord-010119-t1x9gknd 9197 7 % % NN cord-010119-t1x9gknd 9197 8 to to IN cord-010119-t1x9gknd 9197 9 33 33 CD cord-010119-t1x9gknd 9197 10 % % NN cord-010119-t1x9gknd 9197 11 ) ) -RRB- cord-010119-t1x9gknd 9197 12 and and CC cord-010119-t1x9gknd 9198 1 16/17 16/17 CD cord-010119-t1x9gknd 9198 2 ( ( -LRB- cord-010119-t1x9gknd 9198 3 94 94 CD cord-010119-t1x9gknd 9198 4 % % NN cord-010119-t1x9gknd 9198 5 ) ) -RRB- cord-010119-t1x9gknd 9198 6 were be VBD cord-010119-t1x9gknd 9198 7 within within IN cord-010119-t1x9gknd 9198 8 the the DT cord-010119-t1x9gknd 9198 9 95 95 CD cord-010119-t1x9gknd 9198 10 % % NN cord-010119-t1x9gknd 9198 11 control control NN cord-010119-t1x9gknd 9198 12 limit limit NN cord-010119-t1x9gknd 9198 13 . . . cord-010119-t1x9gknd 9199 1 CB CB NNP cord-010119-t1x9gknd 9199 2 that that WDT cord-010119-t1x9gknd 9199 3 required require VBD cord-010119-t1x9gknd 9199 4 ! ! . cord-010119-t1x9gknd 9200 1 10 10 CD cord-010119-t1x9gknd 9200 2 RBCs rbc NNS cord-010119-t1x9gknd 9200 3 within within IN cord-010119-t1x9gknd 9200 4 24-hours 24-hours CD cord-010119-t1x9gknd 9200 5 of of IN cord-010119-t1x9gknd 9200 6 MT MT NNP cord-010119-t1x9gknd 9200 7 onset onset NN cord-010119-t1x9gknd 9200 8 occurred occur VBD cord-010119-t1x9gknd 9200 9 in in IN cord-010119-t1x9gknd 9200 10 40 40 CD cord-010119-t1x9gknd 9200 11 % % NN cord-010119-t1x9gknd 9200 12 of of IN cord-010119-t1x9gknd 9200 13 cases case NNS cord-010119-t1x9gknd 9200 14 . . . cord-010119-t1x9gknd 9201 1 Comparison comparison NN cord-010119-t1x9gknd 9201 2 of of IN cord-010119-t1x9gknd 9201 3 transfusion transfusion NN cord-010119-t1x9gknd 9201 4 management management NN cord-010119-t1x9gknd 9201 5 for for IN cord-010119-t1x9gknd 9201 6 this this DT cord-010119-t1x9gknd 9201 7 subset subset NN cord-010119-t1x9gknd 9201 8 of of IN cord-010119-t1x9gknd 9201 9 MT MT NNP cord-010119-t1x9gknd 9201 10 cases case NNS cord-010119-t1x9gknd 9201 11 showed show VBD cord-010119-t1x9gknd 9201 12 that that IN cord-010119-t1x9gknd 9201 13 patients patient NNS cord-010119-t1x9gknd 9201 14 treated treat VBN cord-010119-t1x9gknd 9201 15 in in IN cord-010119-t1x9gknd 9201 16 smaller small JJR cord-010119-t1x9gknd 9201 17 / / SYM cord-010119-t1x9gknd 9201 18 medium medium JJ cord-010119-t1x9gknd 9201 19 sized sized JJ cord-010119-t1x9gknd 9201 20 acute acute JJ cord-010119-t1x9gknd 9201 21 - - HYPH cord-010119-t1x9gknd 9201 22 care care NN cord-010119-t1x9gknd 9201 23 were be VBD cord-010119-t1x9gknd 9201 24 less less RBR cord-010119-t1x9gknd 9201 25 likely likely JJ cord-010119-t1x9gknd 9201 26 to to TO cord-010119-t1x9gknd 9201 27 receive receive VB cord-010119-t1x9gknd 9201 28 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 9201 29 than than IN cord-010119-t1x9gknd 9201 30 patients patient NNS cord-010119-t1x9gknd 9201 31 treated treat VBN cord-010119-t1x9gknd 9201 32 in in IN cord-010119-t1x9gknd 9201 33 tertiary tertiary JJ cord-010119-t1x9gknd 9201 34 - - HYPH cord-010119-t1x9gknd 9201 35 level level NN cord-010119-t1x9gknd 9201 36 hospitals hospital NNS cord-010119-t1x9gknd 9201 37 ( ( -LRB- cord-010119-t1x9gknd 9201 38 67 67 CD cord-010119-t1x9gknd 9201 39 % % NN cord-010119-t1x9gknd 9201 40 versus versus IN cord-010119-t1x9gknd 9201 41 78 78 CD cord-010119-t1x9gknd 9201 42 % % NN cord-010119-t1x9gknd 9201 43 ; ; : cord-010119-t1x9gknd 9201 44 p50.03 p50.03 CD cord-010119-t1x9gknd 9201 45 ) ) -RRB- cord-010119-t1x9gknd 9201 46 . . . cord-010119-t1x9gknd 9202 1 Conclusion conclusion NN cord-010119-t1x9gknd 9202 2 : : : cord-010119-t1x9gknd 9202 3 Patient patient JJ cord-010119-t1x9gknd 9202 4 characteristics characteristic NNS cord-010119-t1x9gknd 9202 5 and and CC cord-010119-t1x9gknd 9202 6 transfusion transfusion NN cord-010119-t1x9gknd 9202 7 practice practice NN cord-010119-t1x9gknd 9202 8 varied varied JJ cord-010119-t1x9gknd 9202 9 between between IN cord-010119-t1x9gknd 9202 10 hospitals hospital NNS cord-010119-t1x9gknd 9202 11 and and CC cord-010119-t1x9gknd 9202 12 hospital hospital NN cord-010119-t1x9gknd 9202 13 types type NNS cord-010119-t1x9gknd 9202 14 , , , cord-010119-t1x9gknd 9202 15 however however RB cord-010119-t1x9gknd 9202 16 in in IN cord-010119-t1x9gknd 9202 17 - - HYPH cord-010119-t1x9gknd 9202 18 hospital hospital NN cord-010119-t1x9gknd 9202 19 mortality mortality NN cord-010119-t1x9gknd 9202 20 outcomes outcome NNS cord-010119-t1x9gknd 9202 21 were be VBD cord-010119-t1x9gknd 9202 22 comparable comparable JJ cord-010119-t1x9gknd 9202 23 . . . cord-010119-t1x9gknd 9203 1 Results result NNS cord-010119-t1x9gknd 9203 2 are be VBP cord-010119-t1x9gknd 9203 3 made make VBN cord-010119-t1x9gknd 9203 4 available available JJ cord-010119-t1x9gknd 9203 5 to to IN cord-010119-t1x9gknd 9203 6 participating participate VBG cord-010119-t1x9gknd 9203 7 hospitals hospital NNS cord-010119-t1x9gknd 9203 8 in in IN cord-010119-t1x9gknd 9203 9 the the DT cord-010119-t1x9gknd 9203 10 ANZ ANZ NNP cord-010119-t1x9gknd 9203 11 - - HYPH cord-010119-t1x9gknd 9203 12 MTR MTR NNP cord-010119-t1x9gknd 9203 13 to to TO cord-010119-t1x9gknd 9203 14 initiate initiate VB cord-010119-t1x9gknd 9203 15 discussion discussion NN cord-010119-t1x9gknd 9203 16 , , , cord-010119-t1x9gknd 9203 17 practice practice NN cord-010119-t1x9gknd 9203 18 review review NN cord-010119-t1x9gknd 9203 19 , , , cord-010119-t1x9gknd 9203 20 and and CC cord-010119-t1x9gknd 9203 21 examination examination NN cord-010119-t1x9gknd 9203 22 of of IN cord-010119-t1x9gknd 9203 23 compliance compliance NN cord-010119-t1x9gknd 9203 24 with with IN cord-010119-t1x9gknd 9203 25 national national JJ cord-010119-t1x9gknd 9203 26 standards standard NNS cord-010119-t1x9gknd 9203 27 , , , cord-010119-t1x9gknd 9203 28 patient patient JJ cord-010119-t1x9gknd 9203 29 blood blood NN cord-010119-t1x9gknd 9203 30 management management NN cord-010119-t1x9gknd 9203 31 guidelines guideline NNS cord-010119-t1x9gknd 9203 32 and and CC cord-010119-t1x9gknd 9203 33 to to TO cord-010119-t1x9gknd 9203 34 highlight highlight VB cord-010119-t1x9gknd 9203 35 areas area NNS cord-010119-t1x9gknd 9203 36 for for IN cord-010119-t1x9gknd 9203 37 further further JJ cord-010119-t1x9gknd 9203 38 investigation investigation NN cord-010119-t1x9gknd 9203 39 . . . cord-010119-t1x9gknd 9204 1 Data datum NNS cord-010119-t1x9gknd 9204 2 are be VBP cord-010119-t1x9gknd 9204 3 also also RB cord-010119-t1x9gknd 9204 4 available available JJ cord-010119-t1x9gknd 9204 5 for for IN cord-010119-t1x9gknd 9204 6 review review NN cord-010119-t1x9gknd 9204 7 by by IN cord-010119-t1x9gknd 9204 8 governance governance NN cord-010119-t1x9gknd 9204 9 and and CC cord-010119-t1x9gknd 9204 10 policy policy NN cord-010119-t1x9gknd 9204 11 bodies body NNS cord-010119-t1x9gknd 9204 12 at at IN cord-010119-t1x9gknd 9204 13 state state NN cord-010119-t1x9gknd 9204 14 and and CC cord-010119-t1x9gknd 9204 15 national national JJ cord-010119-t1x9gknd 9204 16 level level NN cord-010119-t1x9gknd 9204 17 to to TO cord-010119-t1x9gknd 9204 18 support support VB cord-010119-t1x9gknd 9204 19 practice practice NN cord-010119-t1x9gknd 9204 20 improvement improvement NN cord-010119-t1x9gknd 9204 21 activities activity NNS cord-010119-t1x9gknd 9204 22 and and CC cord-010119-t1x9gknd 9204 23 highlight highlight VB cord-010119-t1x9gknd 9204 24 priority priority NN cord-010119-t1x9gknd 9204 25 areas area NNS cord-010119-t1x9gknd 9204 26 for for IN cord-010119-t1x9gknd 9204 27 future future JJ cord-010119-t1x9gknd 9204 28 research research NN cord-010119-t1x9gknd 9204 29 . . . cord-010119-t1x9gknd 9205 1 Background Background NNP cord-010119-t1x9gknd 9205 2 / / SYM cord-010119-t1x9gknd 9205 3 Case Case NNP cord-010119-t1x9gknd 9205 4 Studies Studies NNPS cord-010119-t1x9gknd 9205 5 : : : cord-010119-t1x9gknd 9206 1 In in IN cord-010119-t1x9gknd 9206 2 hospitals hospital NNS cord-010119-t1x9gknd 9206 3 and and CC cord-010119-t1x9gknd 9206 4 medical medical JJ cord-010119-t1x9gknd 9206 5 centers center NNS cord-010119-t1x9gknd 9206 6 , , , cord-010119-t1x9gknd 9206 7 in in IN cord-010119-t1x9gknd 9206 8 case case NN cord-010119-t1x9gknd 9206 9 of of IN cord-010119-t1x9gknd 9206 10 big big JJ cord-010119-t1x9gknd 9206 11 traumas trauma NNS cord-010119-t1x9gknd 9206 12 often often RB cord-010119-t1x9gknd 9206 13 an an DT cord-010119-t1x9gknd 9206 14 intraosseous intraosseous JJ cord-010119-t1x9gknd 9206 15 entrance entrance NN cord-010119-t1x9gknd 9206 16 via via IN cord-010119-t1x9gknd 9206 17 a a DT cord-010119-t1x9gknd 9206 18 bone bone NN cord-010119-t1x9gknd 9206 19 needle needle NN cord-010119-t1x9gknd 9206 20 is be VBZ cord-010119-t1x9gknd 9206 21 combined combine VBN cord-010119-t1x9gknd 9206 22 with with IN cord-010119-t1x9gknd 9206 23 a a DT cord-010119-t1x9gknd 9206 24 fast fast JJ cord-010119-t1x9gknd 9206 25 flow flow NN cord-010119-t1x9gknd 9206 26 fluid fluid NN cord-010119-t1x9gknd 9206 27 warmer warm JJR cord-010119-t1x9gknd 9206 28 . . . cord-010119-t1x9gknd 9207 1 With with IN cord-010119-t1x9gknd 9207 2 this this DT cord-010119-t1x9gknd 9207 3 , , , cord-010119-t1x9gknd 9207 4 infusion infusion NN cord-010119-t1x9gknd 9207 5 fluids fluid NNS cord-010119-t1x9gknd 9207 6 , , , cord-010119-t1x9gknd 9207 7 including include VBG cord-010119-t1x9gknd 9207 8 blood blood NN cord-010119-t1x9gknd 9207 9 products product NNS cord-010119-t1x9gknd 9207 10 , , , cord-010119-t1x9gknd 9207 11 are be VBP cord-010119-t1x9gknd 9207 12 administered administer VBN cord-010119-t1x9gknd 9207 13 under under IN cord-010119-t1x9gknd 9207 14 pressure pressure NN cord-010119-t1x9gknd 9207 15 . . . cord-010119-t1x9gknd 9208 1 This this DT cord-010119-t1x9gknd 9208 2 is be VBZ cord-010119-t1x9gknd 9208 3 done do VBN cord-010119-t1x9gknd 9208 4 because because IN cord-010119-t1x9gknd 9208 5 veins vein NNS cord-010119-t1x9gknd 9208 6 of of IN cord-010119-t1x9gknd 9208 7 trauma trauma NN cord-010119-t1x9gknd 9208 8 patients patient NNS cord-010119-t1x9gknd 9208 9 are be VBP cord-010119-t1x9gknd 9208 10 often often RB cord-010119-t1x9gknd 9208 11 not not RB cord-010119-t1x9gknd 9208 12 suitable suitable JJ cord-010119-t1x9gknd 9208 13 for for IN cord-010119-t1x9gknd 9208 14 infusion infusion NN cord-010119-t1x9gknd 9208 15 of of IN cord-010119-t1x9gknd 9208 16 fluids fluid NNS cord-010119-t1x9gknd 9208 17 . . . cord-010119-t1x9gknd 9209 1 Suppliers supplier NNS cord-010119-t1x9gknd 9209 2 of of IN cord-010119-t1x9gknd 9209 3 pump pump NN cord-010119-t1x9gknd 9209 4 and and CC cord-010119-t1x9gknd 9209 5 needles needle NNS cord-010119-t1x9gknd 9209 6 describe describe VBP cord-010119-t1x9gknd 9209 7 the the DT cord-010119-t1x9gknd 9209 8 possible possible JJ cord-010119-t1x9gknd 9209 9 transfusion transfusion NN cord-010119-t1x9gknd 9209 10 of of IN cord-010119-t1x9gknd 9209 11 blood blood NN cord-010119-t1x9gknd 9209 12 products product NNS cord-010119-t1x9gknd 9209 13 , , , cord-010119-t1x9gknd 9209 14 but but CC cord-010119-t1x9gknd 9209 15 this this DT cord-010119-t1x9gknd 9209 16 is be VBZ cord-010119-t1x9gknd 9209 17 mainly mainly RB cord-010119-t1x9gknd 9209 18 limited limit VBN cord-010119-t1x9gknd 9209 19 to to IN cord-010119-t1x9gknd 9209 20 plasma plasma NN cord-010119-t1x9gknd 9209 21 and and CC cord-010119-t1x9gknd 9209 22 erythrocytes erythrocyte NNS cord-010119-t1x9gknd 9209 23 . . . cord-010119-t1x9gknd 9210 1 There there EX cord-010119-t1x9gknd 9210 2 is be VBZ cord-010119-t1x9gknd 9210 3 no no DT cord-010119-t1x9gknd 9210 4 information information NN cord-010119-t1x9gknd 9210 5 available available JJ cord-010119-t1x9gknd 9210 6 concerning concern VBG cord-010119-t1x9gknd 9210 7 transfusion transfusion NN cord-010119-t1x9gknd 9210 8 of of IN cord-010119-t1x9gknd 9210 9 platelets platelet NNS cord-010119-t1x9gknd 9210 10 under under IN cord-010119-t1x9gknd 9210 11 pressure pressure NN cord-010119-t1x9gknd 9210 12 via via IN cord-010119-t1x9gknd 9210 13 a a DT cord-010119-t1x9gknd 9210 14 bone bone NN cord-010119-t1x9gknd 9210 15 needle needle NN cord-010119-t1x9gknd 9210 16 . . . cord-010119-t1x9gknd 9211 1 The the DT cord-010119-t1x9gknd 9211 2 aim aim NN cord-010119-t1x9gknd 9211 3 of of IN cord-010119-t1x9gknd 9211 4 the the DT cord-010119-t1x9gknd 9211 5 study study NN cord-010119-t1x9gknd 9211 6 was be VBD cord-010119-t1x9gknd 9211 7 to to TO cord-010119-t1x9gknd 9211 8 investigate investigate VB cord-010119-t1x9gknd 9211 9 the the DT cord-010119-t1x9gknd 9211 10 effects effect NNS cord-010119-t1x9gknd 9211 11 of of IN cord-010119-t1x9gknd 9211 12 warming warming NN cord-010119-t1x9gknd 9211 13 and and CC cord-010119-t1x9gknd 9211 14 administration administration NN cord-010119-t1x9gknd 9211 15 of of IN cord-010119-t1x9gknd 9211 16 a a DT cord-010119-t1x9gknd 9211 17 platelet platelet NN cord-010119-t1x9gknd 9211 18 concentrate concentrate NN cord-010119-t1x9gknd 9211 19 ( ( -LRB- cord-010119-t1x9gknd 9211 20 PC pc NN cord-010119-t1x9gknd 9211 21 ) ) -RRB- cord-010119-t1x9gknd 9211 22 under under IN cord-010119-t1x9gknd 9211 23 pressure pressure NN cord-010119-t1x9gknd 9211 24 via via IN cord-010119-t1x9gknd 9211 25 a a DT cord-010119-t1x9gknd 9211 26 bone bone NN cord-010119-t1x9gknd 9211 27 needle needle NN cord-010119-t1x9gknd 9211 28 on on IN cord-010119-t1x9gknd 9211 29 the the DT cord-010119-t1x9gknd 9211 30 in in FW cord-010119-t1x9gknd 9211 31 vitro vitro FW cord-010119-t1x9gknd 9211 32 quality quality NN cord-010119-t1x9gknd 9211 33 of of IN cord-010119-t1x9gknd 9211 34 platelets platelet NNS cord-010119-t1x9gknd 9211 35 . . . cord-010119-t1x9gknd 9212 1 Study Study NNP cord-010119-t1x9gknd 9212 2 Design Design NNP cord-010119-t1x9gknd 9212 3 / / SYM cord-010119-t1x9gknd 9212 4 Method method NN cord-010119-t1x9gknd 9212 5 : : : cord-010119-t1x9gknd 9212 6 Pools pool NNS cord-010119-t1x9gknd 9212 7 of of IN cord-010119-t1x9gknd 9212 8 5 5 CD cord-010119-t1x9gknd 9212 9 BCs bc NNS cord-010119-t1x9gknd 9212 10 and and CC cord-010119-t1x9gknd 9212 11 280 280 CD cord-010119-t1x9gknd 9212 12 mL ml NN cord-010119-t1x9gknd 9212 13 of of IN cord-010119-t1x9gknd 9212 14 platelet platelet NN cord-010119-t1x9gknd 9212 15 additive additive NN cord-010119-t1x9gknd 9212 16 solution solution NN cord-010119-t1x9gknd 9212 17 III III NNP cord-010119-t1x9gknd 9212 18 ( ( -LRB- cord-010119-t1x9gknd 9212 19 PASIII PASIII NNP cord-010119-t1x9gknd 9212 20 ) ) -RRB- cord-010119-t1x9gknd 9212 21 were be VBD cord-010119-t1x9gknd 9212 22 used use VBN cord-010119-t1x9gknd 9212 23 to to TO cord-010119-t1x9gknd 9212 24 produce produce VB cord-010119-t1x9gknd 9212 25 PCs pc NNS cord-010119-t1x9gknd 9212 26 ( ( -LRB- cord-010119-t1x9gknd 9212 27 n55 n55 NNP cord-010119-t1x9gknd 9212 28 ) ) -RRB- cord-010119-t1x9gknd 9212 29 . . . cord-010119-t1x9gknd 9213 1 PCs pc NNS cord-010119-t1x9gknd 9213 2 were be VBD cord-010119-t1x9gknd 9213 3 stored store VBN cord-010119-t1x9gknd 9213 4 on on IN cord-010119-t1x9gknd 9213 5 a a DT cord-010119-t1x9gknd 9213 6 flatbed flatbed JJ cord-010119-t1x9gknd 9213 7 agitator agitator NN cord-010119-t1x9gknd 9213 8 ( ( -LRB- cord-010119-t1x9gknd 9213 9 60 60 CD cord-010119-t1x9gknd 9213 10 cycles cycle NNS cord-010119-t1x9gknd 9213 11 / / SYM cord-010119-t1x9gknd 9213 12 min min NNP cord-010119-t1x9gknd 9213 13 ) ) -RRB- cord-010119-t1x9gknd 9213 14 in in IN cord-010119-t1x9gknd 9213 15 a a DT cord-010119-t1x9gknd 9213 16 temperature temperature NN cord-010119-t1x9gknd 9213 17 - - HYPH cord-010119-t1x9gknd 9213 18 controlled control VBN cord-010119-t1x9gknd 9213 19 cabinet cabinet NN cord-010119-t1x9gknd 9213 20 at at IN cord-010119-t1x9gknd 9213 21 22 22 CD cord-010119-t1x9gknd 9213 22 6 6 CD cord-010119-t1x9gknd 9213 23 28C 28C NNS cord-010119-t1x9gknd 9213 24 for for IN cord-010119-t1x9gknd 9213 25 4 4 CD cord-010119-t1x9gknd 9213 26 - - SYM cord-010119-t1x9gknd 9213 27 7 7 CD cord-010119-t1x9gknd 9213 28 days day NNS cord-010119-t1x9gknd 9213 29 . . . cord-010119-t1x9gknd 9214 1 To to TO cord-010119-t1x9gknd 9214 2 mimic mimic VB cord-010119-t1x9gknd 9214 3 hospital hospital NN cord-010119-t1x9gknd 9214 4 conditions condition NNS cord-010119-t1x9gknd 9214 5 , , , cord-010119-t1x9gknd 9214 6 PCs pc NNS cord-010119-t1x9gknd 9214 7 were be VBD cord-010119-t1x9gknd 9214 8 warmed warm VBN cord-010119-t1x9gknd 9214 9 using use VBG cord-010119-t1x9gknd 9214 10 a a DT cord-010119-t1x9gknd 9214 11 blood blood NN cord-010119-t1x9gknd 9214 12 warmer warm JJR cord-010119-t1x9gknd 9214 13 and and CC cord-010119-t1x9gknd 9214 14 transfused transfuse VBN cord-010119-t1x9gknd 9214 15 via via IN cord-010119-t1x9gknd 9214 16 a a DT cord-010119-t1x9gknd 9214 17 bone bone NN cord-010119-t1x9gknd 9214 18 needle needle NN cord-010119-t1x9gknd 9214 19 to to IN cord-010119-t1x9gknd 9214 20 a a DT cord-010119-t1x9gknd 9214 21 transfer transfer NN cord-010119-t1x9gknd 9214 22 bag bag NN cord-010119-t1x9gknd 9214 23 . . . cord-010119-t1x9gknd 9215 1 On on IN cord-010119-t1x9gknd 9215 2 the the DT cord-010119-t1x9gknd 9215 3 PCs pc NNS cord-010119-t1x9gknd 9215 4 a a DT cord-010119-t1x9gknd 9215 5 pressure pressure NN cord-010119-t1x9gknd 9215 6 of of IN cord-010119-t1x9gknd 9215 7 300 300 CD cord-010119-t1x9gknd 9215 8 mm mm NN cord-010119-t1x9gknd 9215 9 Hg Hg NNP cord-010119-t1x9gknd 9215 10 was be VBD cord-010119-t1x9gknd 9215 11 applied apply VBN cord-010119-t1x9gknd 9215 12 . . . cord-010119-t1x9gknd 9216 1 Using use VBG cord-010119-t1x9gknd 9216 2 clamps clamp NNS cord-010119-t1x9gknd 9216 3 , , , cord-010119-t1x9gknd 9216 4 a a DT cord-010119-t1x9gknd 9216 5 flow flow NN cord-010119-t1x9gknd 9216 6 velocity velocity NN cord-010119-t1x9gknd 9216 7 of of IN cord-010119-t1x9gknd 9216 8 90 90 CD cord-010119-t1x9gknd 9216 9 - - SYM cord-010119-t1x9gknd 9216 10 120 120 CD cord-010119-t1x9gknd 9216 11 mL ml NN cord-010119-t1x9gknd 9216 12 / / SYM cord-010119-t1x9gknd 9216 13 minute minute NN cord-010119-t1x9gknd 9216 14 was be VBD cord-010119-t1x9gknd 9216 15 realized realize VBN cord-010119-t1x9gknd 9216 16 . . . cord-010119-t1x9gknd 9217 1 Platelet platelet NN cord-010119-t1x9gknd 9217 2 quality quality NN cord-010119-t1x9gknd 9217 3 before before RB cord-010119-t1x9gknd 9217 4 and and CC cord-010119-t1x9gknd 9217 5 after after IN cord-010119-t1x9gknd 9217 6 pressurized pressurize VBN cord-010119-t1x9gknd 9217 7 simulated simulated JJ cord-010119-t1x9gknd 9217 8 transfusion transfusion NN cord-010119-t1x9gknd 9217 9 was be VBD cord-010119-t1x9gknd 9217 10 determined determine VBN cord-010119-t1x9gknd 9217 11 by by IN cord-010119-t1x9gknd 9217 12 means mean NNS cord-010119-t1x9gknd 9217 13 of of IN cord-010119-t1x9gknd 9217 14 various various JJ cord-010119-t1x9gknd 9217 15 in in IN cord-010119-t1x9gknd 9217 16 vitro vitro FW cord-010119-t1x9gknd 9217 17 parameters parameter NNS cord-010119-t1x9gknd 9217 18 . . . cord-010119-t1x9gknd 9218 1 Results result NNS cord-010119-t1x9gknd 9218 2 / / SYM cord-010119-t1x9gknd 9218 3 Finding finding NN cord-010119-t1x9gknd 9218 4 : : : cord-010119-t1x9gknd 9218 5 Due due IN cord-010119-t1x9gknd 9218 6 to to IN cord-010119-t1x9gknd 9218 7 priming priming NN cord-010119-t1x9gknd 9218 8 of of IN cord-010119-t1x9gknd 9218 9 the the DT cord-010119-t1x9gknd 9218 10 transfusion transfusion NN cord-010119-t1x9gknd 9218 11 disposable disposable JJ cord-010119-t1x9gknd 9218 12 with with IN cord-010119-t1x9gknd 9218 13 saline saline NN cord-010119-t1x9gknd 9218 14 , , , cord-010119-t1x9gknd 9218 15 the the DT cord-010119-t1x9gknd 9218 16 PCs pc NNS cord-010119-t1x9gknd 9218 17 were be VBD cord-010119-t1x9gknd 9218 18 diluted dilute VBN cord-010119-t1x9gknd 9218 19 10 10 CD cord-010119-t1x9gknd 9218 20 - - SYM cord-010119-t1x9gknd 9218 21 30 30 CD cord-010119-t1x9gknd 9218 22 % % NN cord-010119-t1x9gknd 9218 23 , , , cord-010119-t1x9gknd 9218 24 resulting result VBG cord-010119-t1x9gknd 9218 25 in in IN cord-010119-t1x9gknd 9218 26 a a DT cord-010119-t1x9gknd 9218 27 significantly significantly RB cord-010119-t1x9gknd 9218 28 increased increase VBN cord-010119-t1x9gknd 9218 29 PC pc NN cord-010119-t1x9gknd 9218 30 volume volume NN cord-010119-t1x9gknd 9218 31 and and CC cord-010119-t1x9gknd 9218 32 decreased decrease VBD cord-010119-t1x9gknd 9218 33 platelet platelet NN cord-010119-t1x9gknd 9218 34 concentration concentration NN cord-010119-t1x9gknd 9218 35 after after IN cord-010119-t1x9gknd 9218 36 simulated simulated JJ cord-010119-t1x9gknd 9218 37 transfusion transfusion NN cord-010119-t1x9gknd 9218 38 . . . cord-010119-t1x9gknd 9219 1 Because because IN cord-010119-t1x9gknd 9219 2 of of IN cord-010119-t1x9gknd 9219 3 loss loss NN cord-010119-t1x9gknd 9219 4 of of IN cord-010119-t1x9gknd 9219 5 platelets platelet NNS cord-010119-t1x9gknd 9219 6 in in IN cord-010119-t1x9gknd 9219 7 the the DT cord-010119-t1x9gknd 9219 8 disposable disposable JJ cord-010119-t1x9gknd 9219 9 set set NN cord-010119-t1x9gknd 9219 10 , , , cord-010119-t1x9gknd 9219 11 also also RB cord-010119-t1x9gknd 9219 12 the the DT cord-010119-t1x9gknd 9219 13 total total JJ cord-010119-t1x9gknd 9219 14 number number NN cord-010119-t1x9gknd 9219 15 of of IN cord-010119-t1x9gknd 9219 16 platelets platelet NNS cord-010119-t1x9gknd 9219 17 was be VBD cord-010119-t1x9gknd 9219 18 decreased decrease VBN cord-010119-t1x9gknd 9219 19 after after IN cord-010119-t1x9gknd 9219 20 simulated simulated JJ cord-010119-t1x9gknd 9219 21 transfusion transfusion NN cord-010119-t1x9gknd 9219 22 . . . cord-010119-t1x9gknd 9220 1 After after IN cord-010119-t1x9gknd 9220 2 simulated simulated JJ cord-010119-t1x9gknd 9220 3 transfusion transfusion NN cord-010119-t1x9gknd 9220 4 , , , cord-010119-t1x9gknd 9220 5 the the DT cord-010119-t1x9gknd 9220 6 PCs pc NNS cord-010119-t1x9gknd 9220 7 still still RB cord-010119-t1x9gknd 9220 8 fulfilled fulfil VBD cord-010119-t1x9gknd 9220 9 the the DT cord-010119-t1x9gknd 9220 10 requirements requirement NNS cord-010119-t1x9gknd 9220 11 for for IN cord-010119-t1x9gknd 9220 12 platelet platelet NN cord-010119-t1x9gknd 9220 13 concentration concentration NN cord-010119-t1x9gknd 9220 14 ( ( -LRB- cord-010119-t1x9gknd 9220 15 0.8 0.8 CD cord-010119-t1x9gknd 9220 16 - - SYM cord-010119-t1x9gknd 9220 17 1.6x10 1.6x10 CD cord-010119-t1x9gknd 9220 18 11 11 CD cord-010119-t1x9gknd 9220 19 /L /L . cord-010119-t1x9gknd 9220 20 ) ) -RRB- cord-010119-t1x9gknd 9220 21 and and CC cord-010119-t1x9gknd 9220 22 number number NN cord-010119-t1x9gknd 9220 23 ( ( -LRB- cord-010119-t1x9gknd 9220 24 > > NFP cord-010119-t1x9gknd 9220 25 250x10 250x10 CD cord-010119-t1x9gknd 9220 26 9 9 CD cord-010119-t1x9gknd 9220 27 /unit /unit . cord-010119-t1x9gknd 9220 28 ) ) -RRB- cord-010119-t1x9gknd 9220 29 . . . cord-010119-t1x9gknd 9221 1 Simulated simulated JJ cord-010119-t1x9gknd 9221 2 transfusion transfusion NN cord-010119-t1x9gknd 9221 3 had have VBD cord-010119-t1x9gknd 9221 4 no no DT cord-010119-t1x9gknd 9221 5 effect effect NN cord-010119-t1x9gknd 9221 6 on on IN cord-010119-t1x9gknd 9221 7 the the DT cord-010119-t1x9gknd 9221 8 percentages percentage NNS cord-010119-t1x9gknd 9221 9 of of IN cord-010119-t1x9gknd 9221 10 CD62P cd62p NN cord-010119-t1x9gknd 9221 11 and and CC cord-010119-t1x9gknd 9221 12 Annexin Annexin NNP cord-010119-t1x9gknd 9221 13 V V NNP cord-010119-t1x9gknd 9221 14 positive positive JJ cord-010119-t1x9gknd 9221 15 cells cell NNS cord-010119-t1x9gknd 9221 16 , , , cord-010119-t1x9gknd 9221 17 indicating indicate VBG cord-010119-t1x9gknd 9221 18 no no DT cord-010119-t1x9gknd 9221 19 activation activation NN cord-010119-t1x9gknd 9221 20 or or CC cord-010119-t1x9gknd 9221 21 induction induction NN cord-010119-t1x9gknd 9221 22 of of IN cord-010119-t1x9gknd 9221 23 apoptosis apoptosis NN cord-010119-t1x9gknd 9221 24 . . . cord-010119-t1x9gknd 9222 1 pH pH NNP cord-010119-t1x9gknd 9222 2 was be VBD cord-010119-t1x9gknd 9222 3 not not RB cord-010119-t1x9gknd 9222 4 influenced influence VBN cord-010119-t1x9gknd 9222 5 by by IN cord-010119-t1x9gknd 9222 6 simulated simulated JJ cord-010119-t1x9gknd 9222 7 transfusion transfusion NN cord-010119-t1x9gknd 9222 8 . . . cord-010119-t1x9gknd 9223 1 Due due IN cord-010119-t1x9gknd 9223 2 to to IN cord-010119-t1x9gknd 9223 3 the the DT cord-010119-t1x9gknd 9223 4 dilution dilution NN cord-010119-t1x9gknd 9223 5 effect effect NN cord-010119-t1x9gknd 9223 6 , , , cord-010119-t1x9gknd 9223 7 glucose glucose NN cord-010119-t1x9gknd 9223 8 and and CC cord-010119-t1x9gknd 9223 9 lactate lactate NN cord-010119-t1x9gknd 9223 10 concentrations concentration NNS cord-010119-t1x9gknd 9223 11 were be VBD cord-010119-t1x9gknd 9223 12 slightly slightly RB cord-010119-t1x9gknd 9223 13 lower low JJR cord-010119-t1x9gknd 9223 14 after after IN cord-010119-t1x9gknd 9223 15 simulated simulated JJ cord-010119-t1x9gknd 9223 16 transfusion transfusion NN cord-010119-t1x9gknd 9223 17 . . . cord-010119-t1x9gknd 9224 1 Conclusion conclusion NN cord-010119-t1x9gknd 9224 2 : : : cord-010119-t1x9gknd 9225 1 Warming warming NN cord-010119-t1x9gknd 9225 2 and and CC cord-010119-t1x9gknd 9225 3 simulated simulated JJ cord-010119-t1x9gknd 9225 4 transfusion transfusion NN cord-010119-t1x9gknd 9225 5 of of IN cord-010119-t1x9gknd 9225 6 PCs pc NNS cord-010119-t1x9gknd 9225 7 under under IN cord-010119-t1x9gknd 9225 8 high high JJ cord-010119-t1x9gknd 9225 9 pressure pressure NN cord-010119-t1x9gknd 9225 10 via via IN cord-010119-t1x9gknd 9225 11 a a DT cord-010119-t1x9gknd 9225 12 bone bone NN cord-010119-t1x9gknd 9225 13 needle needle NN cord-010119-t1x9gknd 9225 14 has have VBZ cord-010119-t1x9gknd 9225 15 no no DT cord-010119-t1x9gknd 9225 16 negative negative JJ cord-010119-t1x9gknd 9225 17 effect effect NN cord-010119-t1x9gknd 9225 18 on on IN cord-010119-t1x9gknd 9225 19 the the DT cord-010119-t1x9gknd 9225 20 in in FW cord-010119-t1x9gknd 9225 21 vitro vitro FW cord-010119-t1x9gknd 9225 22 quality quality NN cord-010119-t1x9gknd 9225 23 parameters parameter NNS cord-010119-t1x9gknd 9225 24 of of IN cord-010119-t1x9gknd 9225 25 platelets platelet NNS cord-010119-t1x9gknd 9225 26 . . . cord-010119-t1x9gknd 9226 1 Transfusion transfusion NN cord-010119-t1x9gknd 9226 2 of of IN cord-010119-t1x9gknd 9226 3 warmed warm VBN cord-010119-t1x9gknd 9226 4 PCs pc NNS cord-010119-t1x9gknd 9226 5 via via IN cord-010119-t1x9gknd 9226 6 an an DT cord-010119-t1x9gknd 9226 7 intraosseous intraosseous JJ cord-010119-t1x9gknd 9226 8 entrance entrance NN cord-010119-t1x9gknd 9226 9 via via IN cord-010119-t1x9gknd 9226 10 a a DT cord-010119-t1x9gknd 9226 11 bone bone NN cord-010119-t1x9gknd 9226 12 needle needle NN cord-010119-t1x9gknd 9226 13 is be VBZ cord-010119-t1x9gknd 9226 14 not not RB cord-010119-t1x9gknd 9226 15 expected expect VBN cord-010119-t1x9gknd 9226 16 to to TO cord-010119-t1x9gknd 9226 17 have have VB cord-010119-t1x9gknd 9226 18 a a DT cord-010119-t1x9gknd 9226 19 negative negative JJ cord-010119-t1x9gknd 9226 20 effect effect NN cord-010119-t1x9gknd 9226 21 on on IN cord-010119-t1x9gknd 9226 22 the the DT cord-010119-t1x9gknd 9226 23 in in IN cord-010119-t1x9gknd 9226 24 vivo vivo NN cord-010119-t1x9gknd 9226 25 functionality functionality NN cord-010119-t1x9gknd 9226 26 of of IN cord-010119-t1x9gknd 9226 27 platelets platelet NNS cord-010119-t1x9gknd 9226 28 . . . cord-010119-t1x9gknd 9227 1 It -PRON- PRP cord-010119-t1x9gknd 9227 2 is be VBZ cord-010119-t1x9gknd 9227 3 recommended recommend VBN cord-010119-t1x9gknd 9227 4 to to TO cord-010119-t1x9gknd 9227 5 study study VB cord-010119-t1x9gknd 9227 6 the the DT cord-010119-t1x9gknd 9227 7 in in IN cord-010119-t1x9gknd 9227 8 vivo vivo NN cord-010119-t1x9gknd 9227 9 effects effect NNS cord-010119-t1x9gknd 9227 10 in in IN cord-010119-t1x9gknd 9227 11 a a DT cord-010119-t1x9gknd 9227 12 limited limited JJ cord-010119-t1x9gknd 9227 13 clinical clinical JJ cord-010119-t1x9gknd 9227 14 study study NN cord-010119-t1x9gknd 9227 15 . . . cord-010119-t1x9gknd 9228 1 Alesia Alesia NNP cord-010119-t1x9gknd 9228 2 Kaplan Kaplan NNP cord-010119-t1x9gknd 9228 3 * * NFP cord-010119-t1x9gknd 9228 4 1,2 1,2 CD cord-010119-t1x9gknd 9228 5 , , , cord-010119-t1x9gknd 9228 6 Joan Joan NNP cord-010119-t1x9gknd 9228 7 Sevcik Sevcik NNP cord-010119-t1x9gknd 9228 8 2 2 CD cord-010119-t1x9gknd 9228 9 and and CC cord-010119-t1x9gknd 9228 10 Joseph Joseph NNP cord-010119-t1x9gknd 9228 11 E. E. NNP cord-010119-t1x9gknd 9228 12 Kiss Kiss NNP cord-010119-t1x9gknd 9228 13 1,2 1,2 CD cord-010119-t1x9gknd 9228 14 . . . cord-010119-t1x9gknd 9229 1 1 1 CD cord-010119-t1x9gknd 9229 2 University University NNP cord-010119-t1x9gknd 9229 3 of of IN cord-010119-t1x9gknd 9229 4 Pittsburgh Pittsburgh NNP cord-010119-t1x9gknd 9229 5 , , , cord-010119-t1x9gknd 9230 1 2 2 LS cord-010119-t1x9gknd 9230 2 Blood Blood NNP cord-010119-t1x9gknd 9230 3 Systems Systems NNPS cord-010119-t1x9gknd 9230 4 Inc. Inc. NNP cord-010119-t1x9gknd 9230 5 Background Background NNP cord-010119-t1x9gknd 9230 6 / / SYM cord-010119-t1x9gknd 9230 7 Case Case NNP cord-010119-t1x9gknd 9230 8 Studies Studies NNPS cord-010119-t1x9gknd 9230 9 : : : cord-010119-t1x9gknd 9231 1 Low low JJ cord-010119-t1x9gknd 9231 2 titer titer NN cord-010119-t1x9gknd 9232 1 A a DT cord-010119-t1x9gknd 9232 2 plasma plasma NN cord-010119-t1x9gknd 9232 3 has have VBZ cord-010119-t1x9gknd 9232 4 been be VBN cord-010119-t1x9gknd 9232 5 safely safely RB cord-010119-t1x9gknd 9232 6 used use VBN cord-010119-t1x9gknd 9232 7 as as IN cord-010119-t1x9gknd 9232 8 a a DT cord-010119-t1x9gknd 9232 9 substitute substitute NN cord-010119-t1x9gknd 9232 10 for for IN cord-010119-t1x9gknd 9232 11 AB AB NNP cord-010119-t1x9gknd 9232 12 plasma plasma NN cord-010119-t1x9gknd 9232 13 in in IN cord-010119-t1x9gknd 9232 14 trauma trauma NN cord-010119-t1x9gknd 9232 15 patients patient NNS cord-010119-t1x9gknd 9232 16 . . . cord-010119-t1x9gknd 9233 1 Low low JJ cord-010119-t1x9gknd 9233 2 inventories inventory NNS cord-010119-t1x9gknd 9233 3 of of IN cord-010119-t1x9gknd 9233 4 AB ab NN cord-010119-t1x9gknd 9233 5 plasma plasma NN cord-010119-t1x9gknd 9233 6 can can MD cord-010119-t1x9gknd 9233 7 cause cause VB cord-010119-t1x9gknd 9233 8 a a DT cord-010119-t1x9gknd 9233 9 delay delay NN cord-010119-t1x9gknd 9233 10 in in IN cord-010119-t1x9gknd 9233 11 life life NN cord-010119-t1x9gknd 9233 12 saving save VBG cord-010119-t1x9gknd 9233 13 therapeutic therapeutic JJ cord-010119-t1x9gknd 9233 14 plasma plasma NN cord-010119-t1x9gknd 9233 15 exchange exchange NN cord-010119-t1x9gknd 9233 16 ( ( -LRB- cord-010119-t1x9gknd 9233 17 TPE TPE NNP cord-010119-t1x9gknd 9233 18 ) ) -RRB- cord-010119-t1x9gknd 9233 19 procedures procedure NNS cord-010119-t1x9gknd 9233 20 in in IN cord-010119-t1x9gknd 9233 21 AB AB NNP cord-010119-t1x9gknd 9233 22 patients patient NNS cord-010119-t1x9gknd 9233 23 needing need VBG cord-010119-t1x9gknd 9233 24 plasma plasma NN cord-010119-t1x9gknd 9233 25 replacement replacement NN cord-010119-t1x9gknd 9233 26 . . . cord-010119-t1x9gknd 9234 1 Here here RB cord-010119-t1x9gknd 9234 2 , , , cord-010119-t1x9gknd 9234 3 2 2 CD cord-010119-t1x9gknd 9234 4 AB ab NN cord-010119-t1x9gknd 9234 5 non non JJ cord-010119-t1x9gknd 9234 6 - - JJ cord-010119-t1x9gknd 9234 7 bleeding bleeding JJ cord-010119-t1x9gknd 9234 8 patients patient NNS cord-010119-t1x9gknd 9234 9 are be VBP cord-010119-t1x9gknd 9234 10 presented present VBN cord-010119-t1x9gknd 9234 11 who who WP cord-010119-t1x9gknd 9234 12 safely safely RB cord-010119-t1x9gknd 9234 13 received receive VBD cord-010119-t1x9gknd 9234 14 AB AB NNP cord-010119-t1x9gknd 9234 15 and and CC cord-010119-t1x9gknd 9234 16 low low JJ cord-010119-t1x9gknd 9234 17 titer titer NN cord-010119-t1x9gknd 9234 18 A a DT cord-010119-t1x9gknd 9234 19 plasma plasma NN cord-010119-t1x9gknd 9234 20 for for IN cord-010119-t1x9gknd 9234 21 TPE TPE NNP cord-010119-t1x9gknd 9234 22 . . . cord-010119-t1x9gknd 9235 1 One one CD cord-010119-t1x9gknd 9235 2 AB AB NNP cord-010119-t1x9gknd 9235 3 patient patient NN cord-010119-t1x9gknd 9235 4 who who WP cord-010119-t1x9gknd 9235 5 received receive VBD cord-010119-t1x9gknd 9235 6 AB AB NNP cord-010119-t1x9gknd 9235 7 plasma plasma NN cord-010119-t1x9gknd 9235 8 only only RB cord-010119-t1x9gknd 9235 9 was be VBD cord-010119-t1x9gknd 9235 10 used use VBN cord-010119-t1x9gknd 9235 11 as as IN cord-010119-t1x9gknd 9235 12 control control NN cord-010119-t1x9gknd 9235 13 to to TO cord-010119-t1x9gknd 9235 14 compare compare VB cord-010119-t1x9gknd 9235 15 hemolysis hemolysis NN cord-010119-t1x9gknd 9235 16 laboratory laboratory NN cord-010119-t1x9gknd 9235 17 data datum NNS cord-010119-t1x9gknd 9235 18 over over IN cord-010119-t1x9gknd 9235 19 TPE TPE NNP cord-010119-t1x9gknd 9235 20 course course NN cord-010119-t1x9gknd 9235 21 . . . cord-010119-t1x9gknd 9236 1 Study Study NNP cord-010119-t1x9gknd 9236 2 Design Design NNP cord-010119-t1x9gknd 9236 3 / / SYM cord-010119-t1x9gknd 9236 4 Method method NN cord-010119-t1x9gknd 9236 5 : : : cord-010119-t1x9gknd 9237 1 A a DT cord-010119-t1x9gknd 9237 2 retrospective retrospective JJ cord-010119-t1x9gknd 9237 3 review review NN cord-010119-t1x9gknd 9237 4 of of IN cord-010119-t1x9gknd 9237 5 TPE TPE NNP cord-010119-t1x9gknd 9237 6 procedures procedure NNS cord-010119-t1x9gknd 9237 7 for for IN cord-010119-t1x9gknd 9237 8 3 3 CD cord-010119-t1x9gknd 9237 9 patients patient NNS cord-010119-t1x9gknd 9237 10 was be VBD cord-010119-t1x9gknd 9237 11 conducted conduct VBN cord-010119-t1x9gknd 9237 12 from from IN cord-010119-t1x9gknd 9237 13 medical medical JJ cord-010119-t1x9gknd 9237 14 records record NNS cord-010119-t1x9gknd 9237 15 . . . cord-010119-t1x9gknd 9238 1 Number number NN cord-010119-t1x9gknd 9238 2 of of IN cord-010119-t1x9gknd 9238 3 procedures procedure NNS cord-010119-t1x9gknd 9238 4 , , , cord-010119-t1x9gknd 9238 5 volume volume NN cord-010119-t1x9gknd 9238 6 replaced replace VBN cord-010119-t1x9gknd 9238 7 , , , cord-010119-t1x9gknd 9238 8 total total JJ cord-010119-t1x9gknd 9238 9 number number NN cord-010119-t1x9gknd 9238 10 of of IN cord-010119-t1x9gknd 9238 11 plasma plasma NN cord-010119-t1x9gknd 9238 12 units unit NNS cord-010119-t1x9gknd 9238 13 , , , cord-010119-t1x9gknd 9238 14 number number NN cord-010119-t1x9gknd 9238 15 of of IN cord-010119-t1x9gknd 9238 16 A a DT cord-010119-t1x9gknd 9238 17 plasma plasma NN cord-010119-t1x9gknd 9238 18 units unit NNS cord-010119-t1x9gknd 9238 19 , , , cord-010119-t1x9gknd 9238 20 quantity quantity NN cord-010119-t1x9gknd 9238 21 of of IN cord-010119-t1x9gknd 9238 22 A a DT cord-010119-t1x9gknd 9238 23 plasma plasma NN cord-010119-t1x9gknd 9238 24 and and CC cord-010119-t1x9gknd 9238 25 hemolysis hemolysis NN cord-010119-t1x9gknd 9238 26 laboratory laboratory NN cord-010119-t1x9gknd 9238 27 data datum NNS cord-010119-t1x9gknd 9238 28 were be VBD cord-010119-t1x9gknd 9238 29 recorded record VBN cord-010119-t1x9gknd 9238 30 . . . cord-010119-t1x9gknd 9239 1 Average average JJ cord-010119-t1x9gknd 9239 2 quantity quantity NN cord-010119-t1x9gknd 9239 3 ( ( -LRB- cord-010119-t1x9gknd 9239 4 ml ml NN cord-010119-t1x9gknd 9239 5 ) ) -RRB- cord-010119-t1x9gknd 9239 6 for for IN cord-010119-t1x9gknd 9239 7 A a DT cord-010119-t1x9gknd 9239 8 plasma plasma NN cord-010119-t1x9gknd 9239 9 and and CC cord-010119-t1x9gknd 9239 10 % % NN cord-010119-t1x9gknd 9239 11 of of IN cord-010119-t1x9gknd 9239 12 A a DT cord-010119-t1x9gknd 9239 13 plasma plasma NN cord-010119-t1x9gknd 9239 14 out out IN cord-010119-t1x9gknd 9239 15 of of IN cord-010119-t1x9gknd 9239 16 total total JJ cord-010119-t1x9gknd 9239 17 volume volume NN cord-010119-t1x9gknd 9239 18 of of IN cord-010119-t1x9gknd 9239 19 plasma plasma NN cord-010119-t1x9gknd 9239 20 used use VBN cord-010119-t1x9gknd 9239 21 were be VBD cord-010119-t1x9gknd 9239 22 calculated calculate VBN cord-010119-t1x9gknd 9239 23 . . . cord-010119-t1x9gknd 9240 1 All all DT cord-010119-t1x9gknd 9240 2 A a DT cord-010119-t1x9gknd 9240 3 plasma plasma NN cord-010119-t1x9gknd 9240 4 units unit NNS cord-010119-t1x9gknd 9240 5 were be VBD cord-010119-t1x9gknd 9240 6 low low JJ cord-010119-t1x9gknd 9240 7 anti anti AFX cord-010119-t1x9gknd 9240 8 - - JJ cord-010119-t1x9gknd 9240 9 B b JJ cord-010119-t1x9gknd 9240 10 titer titer NN cord-010119-t1x9gknd 9240 11 units unit NNS cord-010119-t1x9gknd 9240 12 . . . cord-010119-t1x9gknd 9241 1 In in IN cord-010119-t1x9gknd 9241 2 the the DT cord-010119-t1x9gknd 9241 3 laboratory laboratory NN cord-010119-t1x9gknd 9241 4 , , , cord-010119-t1x9gknd 9241 5 plasma plasma NN cord-010119-t1x9gknd 9241 6 dilution dilution NN cord-010119-t1x9gknd 9241 7 1:50 1:50 CD cord-010119-t1x9gknd 9241 8 is be VBZ cord-010119-t1x9gknd 9241 9 prepared prepare VBN cord-010119-t1x9gknd 9241 10 and and CC cord-010119-t1x9gknd 9241 11 tested test VBN cord-010119-t1x9gknd 9241 12 with with IN cord-010119-t1x9gknd 9241 13 reagent reagent NN cord-010119-t1x9gknd 9241 14 B b NN cord-010119-t1x9gknd 9241 15 cells cell NNS cord-010119-t1x9gknd 9241 16 . . . cord-010119-t1x9gknd 9242 1 If if IN cord-010119-t1x9gknd 9242 2 agglutination agglutination NN cord-010119-t1x9gknd 9242 3 is be VBZ cord-010119-t1x9gknd 9242 4 not not RB cord-010119-t1x9gknd 9242 5 observed observe VBN cord-010119-t1x9gknd 9242 6 , , , cord-010119-t1x9gknd 9242 7 the the DT cord-010119-t1x9gknd 9242 8 unit unit NN cord-010119-t1x9gknd 9242 9 is be VBZ cord-010119-t1x9gknd 9242 10 labeled label VBN cord-010119-t1x9gknd 9242 11 as as IN cord-010119-t1x9gknd 9242 12 " " `` cord-010119-t1x9gknd 9242 13 low low JJ cord-010119-t1x9gknd 9242 14 titer titer NN cord-010119-t1x9gknd 9242 15 anti anti NN cord-010119-t1x9gknd 9242 16 - - NNP cord-010119-t1x9gknd 9242 17 B B NNP cord-010119-t1x9gknd 9242 18 " " '' cord-010119-t1x9gknd 9242 19 . . . cord-010119-t1x9gknd 9243 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 9243 2 laboratory laboratory NN cord-010119-t1x9gknd 9243 3 data datum NNS cord-010119-t1x9gknd 9243 4 was be VBD cord-010119-t1x9gknd 9243 5 traced trace VBN cord-010119-t1x9gknd 9243 6 with with IN cord-010119-t1x9gknd 9243 7 linear linear JJ cord-010119-t1x9gknd 9243 8 graphs graph NNS cord-010119-t1x9gknd 9243 9 and and CC cord-010119-t1x9gknd 9243 10 trends trend NNS cord-010119-t1x9gknd 9243 11 were be VBD cord-010119-t1x9gknd 9243 12 compared compare VBN cord-010119-t1x9gknd 9243 13 between between IN cord-010119-t1x9gknd 9243 14 patient patient NN cord-010119-t1x9gknd 9243 15 1 1 CD cord-010119-t1x9gknd 9243 16 and and CC cord-010119-t1x9gknd 9243 17 2 2 CD cord-010119-t1x9gknd 9243 18 and and CC cord-010119-t1x9gknd 9243 19 3 3 LS cord-010119-t1x9gknd 9243 20 ( ( -LRB- cord-010119-t1x9gknd 9243 21 control control NN cord-010119-t1x9gknd 9243 22 ) ) -RRB- cord-010119-t1x9gknd 9243 23 . . . cord-010119-t1x9gknd 9244 1 Results/ Results/ . cord-010119-t1x9gknd 9245 1 Finding finding NN cord-010119-t1x9gknd 9245 2 : : : cord-010119-t1x9gknd 9246 1 All all DT cord-010119-t1x9gknd 9246 2 3 3 CD cord-010119-t1x9gknd 9246 3 patients patient NNS cord-010119-t1x9gknd 9246 4 were be VBD cord-010119-t1x9gknd 9246 5 AB AB NNP cord-010119-t1x9gknd 9246 6 blood blood NN cord-010119-t1x9gknd 9246 7 type type NN cord-010119-t1x9gknd 9246 8 . . . cord-010119-t1x9gknd 9247 1 Patient Patient NNP cord-010119-t1x9gknd 9247 2 1 1 CD cord-010119-t1x9gknd 9247 3 , , , cord-010119-t1x9gknd 9247 4 a a DT cord-010119-t1x9gknd 9247 5 57 57 CD cord-010119-t1x9gknd 9247 6 year year NN cord-010119-t1x9gknd 9247 7 old old JJ cord-010119-t1x9gknd 9247 8 female female NN cord-010119-t1x9gknd 9247 9 with with IN cord-010119-t1x9gknd 9247 10 recurrent recurrent JJ cord-010119-t1x9gknd 9247 11 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 9247 12 deficient deficient JJ cord-010119-t1x9gknd 9247 13 TTP ttp NN cord-010119-t1x9gknd 9247 14 , , , cord-010119-t1x9gknd 9247 15 received receive VBD cord-010119-t1x9gknd 9247 16 2 2 CD cord-010119-t1x9gknd 9247 17 courses course NNS cord-010119-t1x9gknd 9247 18 of of IN cord-010119-t1x9gknd 9247 19 TPE TPE NNP cord-010119-t1x9gknd 9247 20 ( ( -LRB- cord-010119-t1x9gknd 9247 21 total total JJ cord-010119-t1x9gknd 9247 22 12 12 CD cord-010119-t1x9gknd 9247 23 TPE TPE NNP cord-010119-t1x9gknd 9247 24 procedures procedure NNS cord-010119-t1x9gknd 9247 25 ) ) -RRB- cord-010119-t1x9gknd 9247 26 for for IN cord-010119-t1x9gknd 9247 27 relapse relapse NN cord-010119-t1x9gknd 9247 28 and and CC cord-010119-t1x9gknd 9247 29 exacerbation exacerbation NN cord-010119-t1x9gknd 9247 30 . . . cord-010119-t1x9gknd 9248 1 Ten ten CD cord-010119-t1x9gknd 9248 2 out out IN cord-010119-t1x9gknd 9248 3 of of IN cord-010119-t1x9gknd 9248 4 12 12 CD cord-010119-t1x9gknd 9248 5 procedures procedure NNS cord-010119-t1x9gknd 9248 6 were be VBD cord-010119-t1x9gknd 9248 7 performed perform VBN cord-010119-t1x9gknd 9248 8 with with IN cord-010119-t1x9gknd 9248 9 AB AB NNP cord-010119-t1x9gknd 9248 10 and and CC cord-010119-t1x9gknd 9248 11 A a DT cord-010119-t1x9gknd 9248 12 plasma plasma NN cord-010119-t1x9gknd 9248 13 ( ( -LRB- cord-010119-t1x9gknd 9248 14 average average JJ cord-010119-t1x9gknd 9248 15 916 916 CD cord-010119-t1x9gknd 9248 16 ml ml NNS cord-010119-t1x9gknd 9248 17 of of IN cord-010119-t1x9gknd 9248 18 A a DT cord-010119-t1x9gknd 9248 19 plasma plasma NN cord-010119-t1x9gknd 9248 20 or or CC cord-010119-t1x9gknd 9248 21 24 24 CD cord-010119-t1x9gknd 9248 22 % % NN cord-010119-t1x9gknd 9248 23 of of IN cord-010119-t1x9gknd 9248 24 total total JJ cord-010119-t1x9gknd 9248 25 plasma plasma NN cord-010119-t1x9gknd 9248 26 volume volume NN cord-010119-t1x9gknd 9248 27 for for IN cord-010119-t1x9gknd 9248 28 10 10 CD cord-010119-t1x9gknd 9248 29 TPE TPE NNP cord-010119-t1x9gknd 9248 30 procedures procedure NNS cord-010119-t1x9gknd 9248 31 ) ) -RRB- cord-010119-t1x9gknd 9248 32 . . . cord-010119-t1x9gknd 9249 1 Patient Patient NNP cord-010119-t1x9gknd 9249 2 2 2 CD cord-010119-t1x9gknd 9249 3 , , , cord-010119-t1x9gknd 9249 4 a a DT cord-010119-t1x9gknd 9249 5 27 27 CD cord-010119-t1x9gknd 9249 6 year year NN cord-010119-t1x9gknd 9249 7 old old JJ cord-010119-t1x9gknd 9249 8 female female NN cord-010119-t1x9gknd 9249 9 with with IN cord-010119-t1x9gknd 9249 10 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 9249 11 , , , cord-010119-t1x9gknd 9249 12 schistocytes schistocyte NNS cord-010119-t1x9gknd 9249 13 and and CC cord-010119-t1x9gknd 9249 14 presumed presume VBN cord-010119-t1x9gknd 9249 15 TTP TTP NNP cord-010119-t1x9gknd 9249 16 , , , cord-010119-t1x9gknd 9249 17 received receive VBD cord-010119-t1x9gknd 9249 18 a a DT cord-010119-t1x9gknd 9249 19 total total NN cord-010119-t1x9gknd 9249 20 of of IN cord-010119-t1x9gknd 9249 21 12 12 CD cord-010119-t1x9gknd 9249 22 TPE TPE NNP cord-010119-t1x9gknd 9249 23 procedures procedure NNS cord-010119-t1x9gknd 9249 24 . . . cord-010119-t1x9gknd 9250 1 Four four CD cord-010119-t1x9gknd 9250 2 out out IN cord-010119-t1x9gknd 9250 3 of of IN cord-010119-t1x9gknd 9250 4 12 12 CD cord-010119-t1x9gknd 9250 5 procedures procedure NNS cord-010119-t1x9gknd 9250 6 were be VBD cord-010119-t1x9gknd 9250 7 performed perform VBN cord-010119-t1x9gknd 9250 8 with with IN cord-010119-t1x9gknd 9250 9 AB AB NNP cord-010119-t1x9gknd 9250 10 and and CC cord-010119-t1x9gknd 9250 11 A a DT cord-010119-t1x9gknd 9250 12 plasma plasma NN cord-010119-t1x9gknd 9250 13 ( ( -LRB- cord-010119-t1x9gknd 9250 14 average average JJ cord-010119-t1x9gknd 9250 15 1210.5 1210.5 CD cord-010119-t1x9gknd 9250 16 ml ml NNS cord-010119-t1x9gknd 9250 17 of of IN cord-010119-t1x9gknd 9250 18 A a DT cord-010119-t1x9gknd 9250 19 plasma plasma NN cord-010119-t1x9gknd 9250 20 or or CC cord-010119-t1x9gknd 9250 21 48 48 CD cord-010119-t1x9gknd 9250 22 % % NN cord-010119-t1x9gknd 9250 23 of of IN cord-010119-t1x9gknd 9250 24 total total JJ cord-010119-t1x9gknd 9250 25 plasma plasma NN cord-010119-t1x9gknd 9250 26 volume volume NN cord-010119-t1x9gknd 9250 27 for for IN cord-010119-t1x9gknd 9250 28 4 4 CD cord-010119-t1x9gknd 9250 29 TPE TPE NNP cord-010119-t1x9gknd 9250 30 procedures procedure NNS cord-010119-t1x9gknd 9250 31 ) ) -RRB- cord-010119-t1x9gknd 9250 32 . . . cord-010119-t1x9gknd 9251 1 Patient Patient NNP cord-010119-t1x9gknd 9251 2 3 3 CD cord-010119-t1x9gknd 9251 3 , , , cord-010119-t1x9gknd 9251 4 a a DT cord-010119-t1x9gknd 9251 5 33 33 CD cord-010119-t1x9gknd 9251 6 year year NN cord-010119-t1x9gknd 9251 7 old old JJ cord-010119-t1x9gknd 9251 8 female female NN cord-010119-t1x9gknd 9251 9 with with IN cord-010119-t1x9gknd 9251 10 ADAMTS13 ADAMTS13 NNP cord-010119-t1x9gknd 9251 11 deficient deficient JJ cord-010119-t1x9gknd 9251 12 TTP TTP NNP cord-010119-t1x9gknd 9251 13 who who WP cord-010119-t1x9gknd 9251 14 served serve VBD cord-010119-t1x9gknd 9251 15 as as IN cord-010119-t1x9gknd 9251 16 a a DT cord-010119-t1x9gknd 9251 17 control control NN cord-010119-t1x9gknd 9251 18 , , , cord-010119-t1x9gknd 9251 19 received receive VBD cord-010119-t1x9gknd 9251 20 a a DT cord-010119-t1x9gknd 9251 21 total total NN cord-010119-t1x9gknd 9251 22 of of IN cord-010119-t1x9gknd 9251 23 10 10 CD cord-010119-t1x9gknd 9251 24 procedures procedure NNS cord-010119-t1x9gknd 9251 25 with with IN cord-010119-t1x9gknd 9251 26 AB ab NN cord-010119-t1x9gknd 9251 27 plasma plasma NN cord-010119-t1x9gknd 9251 28 only only RB cord-010119-t1x9gknd 9251 29 . . . cord-010119-t1x9gknd 9252 1 Haptoglobin Haptoglobin NNP cord-010119-t1x9gknd 9252 2 , , , cord-010119-t1x9gknd 9252 3 LDH LDH NNP cord-010119-t1x9gknd 9252 4 , , , cord-010119-t1x9gknd 9252 5 hemoglobin hemoglobin NN cord-010119-t1x9gknd 9252 6 and and CC cord-010119-t1x9gknd 9252 7 total total JJ cord-010119-t1x9gknd 9252 8 bilirubin bilirubin NN cord-010119-t1x9gknd 9252 9 were be VBD cord-010119-t1x9gknd 9252 10 graphed graph VBN cord-010119-t1x9gknd 9252 11 and and CC cord-010119-t1x9gknd 9252 12 compared compare VBN cord-010119-t1x9gknd 9252 13 between between IN cord-010119-t1x9gknd 9252 14 3 3 CD cord-010119-t1x9gknd 9252 15 patients patient NNS cord-010119-t1x9gknd 9252 16 . . . cord-010119-t1x9gknd 9253 1 The the DT cord-010119-t1x9gknd 9253 2 trends trend NNS cord-010119-t1x9gknd 9253 3 of of IN cord-010119-t1x9gknd 9253 4 hemolysis hemolysis NN cord-010119-t1x9gknd 9253 5 laboratory laboratory NN cord-010119-t1x9gknd 9253 6 data datum NNS cord-010119-t1x9gknd 9253 7 for for IN cord-010119-t1x9gknd 9253 8 patient patient NN cord-010119-t1x9gknd 9253 9 1 1 CD cord-010119-t1x9gknd 9253 10 and and CC cord-010119-t1x9gknd 9253 11 2 2 CD cord-010119-t1x9gknd 9253 12 were be VBD cord-010119-t1x9gknd 9253 13 comparable comparable JJ cord-010119-t1x9gknd 9253 14 with with IN cord-010119-t1x9gknd 9253 15 patient patient NN cord-010119-t1x9gknd 9253 16 3 3 CD cord-010119-t1x9gknd 9253 17 . . . cord-010119-t1x9gknd 9254 1 All all DT cord-010119-t1x9gknd 9254 2 3 3 CD cord-010119-t1x9gknd 9254 3 patients patient NNS cord-010119-t1x9gknd 9254 4 had have VBD cord-010119-t1x9gknd 9254 5 negative negative JJ cord-010119-t1x9gknd 9254 6 DAT dat NN cord-010119-t1x9gknd 9254 7 . . . cord-010119-t1x9gknd 9255 1 Only only RB cord-010119-t1x9gknd 9255 2 patient patient JJ cord-010119-t1x9gknd 9255 3 3 3 CD cord-010119-t1x9gknd 9255 4 received receive VBD cord-010119-t1x9gknd 9255 5 2 2 CD cord-010119-t1x9gknd 9255 6 RBC RBC NNP cord-010119-t1x9gknd 9255 7 transfusions transfusion NNS cord-010119-t1x9gknd 9255 8 . . . cord-010119-t1x9gknd 9256 1 All all DT cord-010119-t1x9gknd 9256 2 3 3 CD cord-010119-t1x9gknd 9256 3 patients patient NNS cord-010119-t1x9gknd 9256 4 had have VBD cord-010119-t1x9gknd 9256 5 a a DT cord-010119-t1x9gknd 9256 6 favorable favorable JJ cord-010119-t1x9gknd 9256 7 clinical clinical JJ cord-010119-t1x9gknd 9256 8 outcome outcome NN cord-010119-t1x9gknd 9256 9 with with IN cord-010119-t1x9gknd 9256 10 TPE TPE NNP cord-010119-t1x9gknd 9256 11 treatments treatment NNS cord-010119-t1x9gknd 9256 12 and and CC cord-010119-t1x9gknd 9256 13 adequate adequate JJ cord-010119-t1x9gknd 9256 14 platelet platelet NN cord-010119-t1x9gknd 9256 15 recovery recovery NN cord-010119-t1x9gknd 9256 16 . . . cord-010119-t1x9gknd 9257 1 Conclusion conclusion NN cord-010119-t1x9gknd 9257 2 : : : cord-010119-t1x9gknd 9257 3 In in IN cord-010119-t1x9gknd 9257 4 this this DT cord-010119-t1x9gknd 9257 5 study study NN cord-010119-t1x9gknd 9257 6 , , , cord-010119-t1x9gknd 9257 7 TPE TPE NNP cord-010119-t1x9gknd 9257 8 was be VBD cord-010119-t1x9gknd 9257 9 effectively effectively RB cord-010119-t1x9gknd 9257 10 performed perform VBN cord-010119-t1x9gknd 9257 11 without without IN cord-010119-t1x9gknd 9257 12 evidence evidence NN cord-010119-t1x9gknd 9257 13 of of IN cord-010119-t1x9gknd 9257 14 increased increase VBN cord-010119-t1x9gknd 9257 15 hemolysis hemolysis NN cord-010119-t1x9gknd 9257 16 using use VBG cord-010119-t1x9gknd 9257 17 up up IN cord-010119-t1x9gknd 9257 18 to to TO cord-010119-t1x9gknd 9257 19 48 48 CD cord-010119-t1x9gknd 9257 20 % % NN cord-010119-t1x9gknd 9257 21 of of IN cord-010119-t1x9gknd 9257 22 low low JJ cord-010119-t1x9gknd 9257 23 titer titer NN cord-010119-t1x9gknd 9257 24 A a DT cord-010119-t1x9gknd 9257 25 plasma plasma NN cord-010119-t1x9gknd 9257 26 . . . cord-010119-t1x9gknd 9258 1 This this DT cord-010119-t1x9gknd 9258 2 approach approach NN cord-010119-t1x9gknd 9258 3 can can MD cord-010119-t1x9gknd 9258 4 reduce reduce VB cord-010119-t1x9gknd 9258 5 strains strain NNS cord-010119-t1x9gknd 9258 6 on on IN cord-010119-t1x9gknd 9258 7 limited limited JJ cord-010119-t1x9gknd 9258 8 supplies supply NNS cord-010119-t1x9gknd 9258 9 of of IN cord-010119-t1x9gknd 9258 10 AB ab NN cord-010119-t1x9gknd 9258 11 plasma plasma NN cord-010119-t1x9gknd 9258 12 while while IN cord-010119-t1x9gknd 9258 13 providing provide VBG cord-010119-t1x9gknd 9258 14 a a DT cord-010119-t1x9gknd 9258 15 vital vital JJ cord-010119-t1x9gknd 9258 16 treatment treatment NN cord-010119-t1x9gknd 9258 17 alternative alternative NN cord-010119-t1x9gknd 9258 18 for for IN cord-010119-t1x9gknd 9258 19 AB AB NNP cord-010119-t1x9gknd 9258 20 patients patient NNS cord-010119-t1x9gknd 9258 21 undergoing undergo VBG cord-010119-t1x9gknd 9258 22 TPE TPE NNP cord-010119-t1x9gknd 9258 23 who who WP cord-010119-t1x9gknd 9258 24 require require VBP cord-010119-t1x9gknd 9258 25 plasma plasma NN cord-010119-t1x9gknd 9258 26 replacement replacement NN cord-010119-t1x9gknd 9258 27 . . . cord-010119-t1x9gknd 9259 1 When when WRB cord-010119-t1x9gknd 9259 2 CD36 CD36 NNP cord-010119-t1x9gknd 9259 3 Negative Negative NNP cord-010119-t1x9gknd 9259 4 Platelet Platelet NNP cord-010119-t1x9gknd 9259 5 Unit Unit NNP cord-010119-t1x9gknd 9259 6 Is be VBZ cord-010119-t1x9gknd 9259 7 Not not RB cord-010119-t1x9gknd 9259 8 Available available JJ cord-010119-t1x9gknd 9259 9 for for IN cord-010119-t1x9gknd 9259 10 a a DT cord-010119-t1x9gknd 9259 11 Patient patient NN cord-010119-t1x9gknd 9259 12 with with IN cord-010119-t1x9gknd 9259 13 Anti Anti NNP cord-010119-t1x9gknd 9259 14 - - JJ cord-010119-t1x9gknd 9259 15 CD36 CD36 NNP cord-010119-t1x9gknd 9259 16 Antibodies Antibodies NNPS cord-010119-t1x9gknd 9260 1 Sameer Sameer NNP cord-010119-t1x9gknd 9260 2 Khatri Khatri NNP cord-010119-t1x9gknd 9260 3 * * NFP cord-010119-t1x9gknd 9260 4 1 1 CD cord-010119-t1x9gknd 9260 5 , , , cord-010119-t1x9gknd 9260 6 Charles Charles NNP cord-010119-t1x9gknd 9260 7 Harmon Harmon NNP cord-010119-t1x9gknd 9260 8 1 1 CD cord-010119-t1x9gknd 9260 9 , , , cord-010119-t1x9gknd 9260 10 Brian Brian NNP cord-010119-t1x9gknd 9260 11 R R NNP cord-010119-t1x9gknd 9260 12 Curtis Curtis NNP cord-010119-t1x9gknd 9260 13 2 2 CD cord-010119-t1x9gknd 9260 14 and and CC cord-010119-t1x9gknd 9260 15 Chisa Chisa NNP cord-010119-t1x9gknd 9260 16 Yamada Yamada NNP cord-010119-t1x9gknd 9260 17 1 1 CD cord-010119-t1x9gknd 9260 18 . . . cord-010119-t1x9gknd 9261 1 Background Background NNP cord-010119-t1x9gknd 9261 2 / / SYM cord-010119-t1x9gknd 9261 3 Case Case NNP cord-010119-t1x9gknd 9261 4 Studies Studies NNPS cord-010119-t1x9gknd 9261 5 : : : cord-010119-t1x9gknd 9261 6 Refractoriness Refractoriness NNP cord-010119-t1x9gknd 9261 7 to to TO cord-010119-t1x9gknd 9261 8 platelet platelet NN cord-010119-t1x9gknd 9262 1 ( ( -LRB- cord-010119-t1x9gknd 9262 2 PLT PLT NNP cord-010119-t1x9gknd 9262 3 ) ) -RRB- cord-010119-t1x9gknd 9262 4 transfusion transfusion NN cord-010119-t1x9gknd 9262 5 can can MD cord-010119-t1x9gknd 9262 6 be be VB cord-010119-t1x9gknd 9262 7 caused cause VBN cord-010119-t1x9gknd 9262 8 by by IN cord-010119-t1x9gknd 9262 9 antibodies antibody NNS cord-010119-t1x9gknd 9262 10 ( ( -LRB- cord-010119-t1x9gknd 9262 11 Abs abs UH cord-010119-t1x9gknd 9262 12 ) ) -RRB- cord-010119-t1x9gknd 9262 13 against against IN cord-010119-t1x9gknd 9262 14 Human Human NNP cord-010119-t1x9gknd 9262 15 Leukocyte Leukocyte NNP cord-010119-t1x9gknd 9262 16 Antigen Antigen NNP cord-010119-t1x9gknd 9262 17 ( ( -LRB- cord-010119-t1x9gknd 9262 18 HLA HLA NNP cord-010119-t1x9gknd 9262 19 ) ) -RRB- cord-010119-t1x9gknd 9262 20 class class NN cord-010119-t1x9gknd 9262 21 I -PRON- PRP cord-010119-t1x9gknd 9262 22 antigens antigen VBZ cord-010119-t1x9gknd 9262 23 ( ( -LRB- cord-010119-t1x9gknd 9262 24 Ags Ags NNP cord-010119-t1x9gknd 9262 25 ) ) -RRB- cord-010119-t1x9gknd 9262 26 or or CC cord-010119-t1x9gknd 9262 27 less less RBR cord-010119-t1x9gknd 9262 28 frequently frequently RB cord-010119-t1x9gknd 9262 29 against against IN cord-010119-t1x9gknd 9262 30 PLT PLT NNP cord-010119-t1x9gknd 9262 31 specific specific JJ cord-010119-t1x9gknd 9262 32 Ags Ags NNP cord-010119-t1x9gknd 9262 33 ( ( -LRB- cord-010119-t1x9gknd 9262 34 PSAs PSAs NNP cord-010119-t1x9gknd 9262 35 ) ) -RRB- cord-010119-t1x9gknd 9262 36 . . . cord-010119-t1x9gknd 9263 1 Glycoprotein Glycoprotein NNP cord-010119-t1x9gknd 9263 2 IV IV NNP cord-010119-t1x9gknd 9263 3 ( ( -LRB- cord-010119-t1x9gknd 9263 4 CD36 CD36 NNP cord-010119-t1x9gknd 9263 5 ) ) -RRB- cord-010119-t1x9gknd 9263 6 is be VBZ cord-010119-t1x9gknd 9263 7 one one CD cord-010119-t1x9gknd 9263 8 of of IN cord-010119-t1x9gknd 9263 9 the the DT cord-010119-t1x9gknd 9263 10 identified identify VBN cord-010119-t1x9gknd 9263 11 PLT PLT NNP cord-010119-t1x9gknd 9263 12 surface surface NN cord-010119-t1x9gknd 9263 13 Ags Ags NNP cord-010119-t1x9gknd 9263 14 and and CC cord-010119-t1x9gknd 9263 15 deficiency deficiency NN cord-010119-t1x9gknd 9263 16 is be VBZ cord-010119-t1x9gknd 9263 17 rare rare JJ cord-010119-t1x9gknd 9263 18 , , , cord-010119-t1x9gknd 9263 19 but but CC cord-010119-t1x9gknd 9263 20 found find VBN cord-010119-t1x9gknd 9263 21 in in IN cord-010119-t1x9gknd 9263 22 Asians Asians NNPS cord-010119-t1x9gknd 9263 23 ( ( -LRB- cord-010119-t1x9gknd 9263 24 3 3 CD cord-010119-t1x9gknd 9263 25 - - SYM cord-010119-t1x9gknd 9263 26 11 11 CD cord-010119-t1x9gknd 9263 27 % % NN cord-010119-t1x9gknd 9263 28 ) ) -RRB- cord-010119-t1x9gknd 9263 29 , , , cord-010119-t1x9gknd 9263 30 sub sub JJ cord-010119-t1x9gknd 9263 31 - - JJ cord-010119-t1x9gknd 9263 32 Saharan saharan JJ cord-010119-t1x9gknd 9263 33 Africans Africans NNPS cord-010119-t1x9gknd 9263 34 ( ( -LRB- cord-010119-t1x9gknd 9263 35 7 7 CD cord-010119-t1x9gknd 9263 36 - - SYM cord-010119-t1x9gknd 9263 37 8 8 CD cord-010119-t1x9gknd 9263 38 % % NN cord-010119-t1x9gknd 9263 39 ) ) -RRB- cord-010119-t1x9gknd 9263 40 and and CC cord-010119-t1x9gknd 9263 41 also also RB cord-010119-t1x9gknd 9263 42 in in IN cord-010119-t1x9gknd 9263 43 some some DT cord-010119-t1x9gknd 9263 44 people people NNS cord-010119-t1x9gknd 9263 45 from from IN cord-010119-t1x9gknd 9263 46 Mediterranean mediterranean JJ cord-010119-t1x9gknd 9263 47 descent descent NN cord-010119-t1x9gknd 9263 48 . . . cord-010119-t1x9gknd 9264 1 Two two CD cord-010119-t1x9gknd 9264 2 types type NNS cord-010119-t1x9gknd 9264 3 of of IN cord-010119-t1x9gknd 9264 4 CD36 CD36 NNP cord-010119-t1x9gknd 9264 5 deficiency deficiency NN cord-010119-t1x9gknd 9264 6 have have VBP cord-010119-t1x9gknd 9264 7 been be VBN cord-010119-t1x9gknd 9264 8 described describe VBN cord-010119-t1x9gknd 9264 9 . . . cord-010119-t1x9gknd 9265 1 Type type NN cord-010119-t1x9gknd 9265 2 1 1 CD cord-010119-t1x9gknd 9265 3 deficiency deficiency NN cord-010119-t1x9gknd 9265 4 is be VBZ cord-010119-t1x9gknd 9265 5 the the DT cord-010119-t1x9gknd 9265 6 complete complete JJ cord-010119-t1x9gknd 9265 7 lack lack NN cord-010119-t1x9gknd 9265 8 of of IN cord-010119-t1x9gknd 9265 9 CD36 CD36 NNP cord-010119-t1x9gknd 9265 10 on on IN cord-010119-t1x9gknd 9265 11 both both DT cord-010119-t1x9gknd 9265 12 PLTs plt NNS cord-010119-t1x9gknd 9265 13 and and CC cord-010119-t1x9gknd 9265 14 monocyte monocyte NN cord-010119-t1x9gknd 9265 15 - - HYPH cord-010119-t1x9gknd 9265 16 macrophages macrophage NNS cord-010119-t1x9gknd 9265 17 whereas whereas IN cord-010119-t1x9gknd 9265 18 type type NN cord-010119-t1x9gknd 9265 19 2 2 CD cord-010119-t1x9gknd 9265 20 deficiency deficiency NN cord-010119-t1x9gknd 9265 21 lacks lack VBZ cord-010119-t1x9gknd 9265 22 CD36 CD36 NNP cord-010119-t1x9gknd 9265 23 on on IN cord-010119-t1x9gknd 9265 24 PLTs plt NNS cord-010119-t1x9gknd 9265 25 with with IN cord-010119-t1x9gknd 9265 26 variable variable JJ cord-010119-t1x9gknd 9265 27 expression expression NN cord-010119-t1x9gknd 9265 28 ( ( -LRB- cord-010119-t1x9gknd 9265 29 12 12 CD cord-010119-t1x9gknd 9265 30 - - SYM cord-010119-t1x9gknd 9265 31 99 99 CD cord-010119-t1x9gknd 9265 32 % % NN cord-010119-t1x9gknd 9265 33 ) ) -RRB- cord-010119-t1x9gknd 9265 34 on on IN cord-010119-t1x9gknd 9265 35 monocytemacrophages monocytemacrophage NNS cord-010119-t1x9gknd 9265 36 . . . cord-010119-t1x9gknd 9266 1 Transfusing Transfusing NNP cord-010119-t1x9gknd 9266 2 PLTs plt NNS cord-010119-t1x9gknd 9266 3 in in IN cord-010119-t1x9gknd 9266 4 a a DT cord-010119-t1x9gknd 9266 5 patient patient NN cord-010119-t1x9gknd 9266 6 with with IN cord-010119-t1x9gknd 9266 7 CD36 CD36 NNP cord-010119-t1x9gknd 9266 8 deficiency deficiency NN cord-010119-t1x9gknd 9266 9 is be VBZ cord-010119-t1x9gknd 9266 10 challenging challenge VBG cord-010119-t1x9gknd 9266 11 given give VBN cord-010119-t1x9gknd 9266 12 the the DT cord-010119-t1x9gknd 9266 13 rarity rarity NN cord-010119-t1x9gknd 9266 14 of of IN cord-010119-t1x9gknd 9266 15 CD36 CD36 NNP cord-010119-t1x9gknd 9266 16 negative negative JJ cord-010119-t1x9gknd 9266 17 phenotype phenotype NN cord-010119-t1x9gknd 9266 18 and and CC cord-010119-t1x9gknd 9266 19 risk risk NN cord-010119-t1x9gknd 9266 20 of of IN cord-010119-t1x9gknd 9266 21 further further JJ cord-010119-t1x9gknd 9266 22 immunization immunization NN cord-010119-t1x9gknd 9266 23 when when WRB cord-010119-t1x9gknd 9266 24 giving give VBG cord-010119-t1x9gknd 9266 25 Ag Ag NNP cord-010119-t1x9gknd 9266 26 non non JJ cord-010119-t1x9gknd 9266 27 - - JJ cord-010119-t1x9gknd 9266 28 matched matched JJ cord-010119-t1x9gknd 9266 29 platelets platelet NNS cord-010119-t1x9gknd 9266 30 . . . cord-010119-t1x9gknd 9267 1 Study Study NNP cord-010119-t1x9gknd 9267 2 Design Design NNP cord-010119-t1x9gknd 9267 3 / / SYM cord-010119-t1x9gknd 9267 4 Method method NN cord-010119-t1x9gknd 9267 5 : : : cord-010119-t1x9gknd 9268 1 A a DT cord-010119-t1x9gknd 9268 2 patient patient NN cord-010119-t1x9gknd 9268 3 with with IN cord-010119-t1x9gknd 9268 4 CD36 CD36 NNP cord-010119-t1x9gknd 9268 5 negative negative JJ cord-010119-t1x9gknd 9268 6 phenotype phenotype NN cord-010119-t1x9gknd 9268 7 who who WP cord-010119-t1x9gknd 9268 8 received receive VBD cord-010119-t1x9gknd 9268 9 multiple multiple JJ cord-010119-t1x9gknd 9268 10 PLT PLT NNP cord-010119-t1x9gknd 9268 11 units unit NNS cord-010119-t1x9gknd 9268 12 was be VBD cord-010119-t1x9gknd 9268 13 reviewed review VBN cord-010119-t1x9gknd 9268 14 in in IN cord-010119-t1x9gknd 9268 15 the the DT cord-010119-t1x9gknd 9268 16 electronic electronic JJ cord-010119-t1x9gknd 9268 17 medical medical JJ cord-010119-t1x9gknd 9268 18 record record NN cord-010119-t1x9gknd 9268 19 . . . cord-010119-t1x9gknd 9269 1 Results/ Results/ . cord-010119-t1x9gknd 9270 1 Finding finding NN cord-010119-t1x9gknd 9270 2 : : : cord-010119-t1x9gknd 9271 1 A a DT cord-010119-t1x9gknd 9271 2 21 21 CD cord-010119-t1x9gknd 9271 3 year year NN cord-010119-t1x9gknd 9271 4 old old JJ cord-010119-t1x9gknd 9271 5 man man NN cord-010119-t1x9gknd 9271 6 developed develop VBD cord-010119-t1x9gknd 9271 7 aplastic aplastic JJ cord-010119-t1x9gknd 9271 8 anemia anemia NN cord-010119-t1x9gknd 9271 9 following follow VBG cord-010119-t1x9gknd 9271 10 liver liver NN cord-010119-t1x9gknd 9271 11 injury injury NN cord-010119-t1x9gknd 9271 12 possibly possibly RB cord-010119-t1x9gknd 9271 13 due due IN cord-010119-t1x9gknd 9271 14 to to IN cord-010119-t1x9gknd 9271 15 a a DT cord-010119-t1x9gknd 9271 16 supplement supplement NN cord-010119-t1x9gknd 9271 17 for for IN cord-010119-t1x9gknd 9271 18 body body NN cord-010119-t1x9gknd 9271 19 building building NN cord-010119-t1x9gknd 9271 20 and and CC cord-010119-t1x9gknd 9271 21 required require VBD cord-010119-t1x9gknd 9271 22 multiple multiple JJ cord-010119-t1x9gknd 9271 23 PLT PLT NNP cord-010119-t1x9gknd 9271 24 and and CC cord-010119-t1x9gknd 9271 25 RBC RBC NNP cord-010119-t1x9gknd 9271 26 transfusions transfusion NNS cord-010119-t1x9gknd 9271 27 . . . cord-010119-t1x9gknd 9272 1 He -PRON- PRP cord-010119-t1x9gknd 9272 2 received receive VBD cord-010119-t1x9gknd 9272 3 more more JJR cord-010119-t1x9gknd 9272 4 than than IN cord-010119-t1x9gknd 9272 5 20 20 CD cord-010119-t1x9gknd 9272 6 units unit NNS cord-010119-t1x9gknd 9272 7 of of IN cord-010119-t1x9gknd 9272 8 apheresis apheresis NN cord-010119-t1x9gknd 9272 9 PLT PLT NNP cord-010119-t1x9gknd 9272 10 units unit NNS cord-010119-t1x9gknd 9272 11 over over IN cord-010119-t1x9gknd 9272 12 a a DT cord-010119-t1x9gknd 9272 13 2 2 CD cord-010119-t1x9gknd 9272 14 week week NN cord-010119-t1x9gknd 9272 15 period period NN cord-010119-t1x9gknd 9272 16 without without IN cord-010119-t1x9gknd 9272 17 any any DT cord-010119-t1x9gknd 9272 18 significant significant JJ cord-010119-t1x9gknd 9272 19 increase increase NN cord-010119-t1x9gknd 9272 20 in in IN cord-010119-t1x9gknd 9272 21 PLT PLT NNP cord-010119-t1x9gknd 9272 22 count count NN cord-010119-t1x9gknd 9272 23 . . . cord-010119-t1x9gknd 9273 1 Cross cross NN cord-010119-t1x9gknd 9273 2 - - NN cord-010119-t1x9gknd 9273 3 match match VB cord-010119-t1x9gknd 9273 4 compatible compatible JJ cord-010119-t1x9gknd 9273 5 PLT PLT NNP cord-010119-t1x9gknd 9273 6 unit unit NN cord-010119-t1x9gknd 9273 7 found find VBD cord-010119-t1x9gknd 9273 8 in in IN cord-010119-t1x9gknd 9273 9 1 1 CD cord-010119-t1x9gknd 9273 10 of of IN cord-010119-t1x9gknd 9273 11 32 32 CD cord-010119-t1x9gknd 9273 12 units unit NNS cord-010119-t1x9gknd 9273 13 and and CC cord-010119-t1x9gknd 9273 14 HLA HLA NNP cord-010119-t1x9gknd 9273 15 matched match VBD cord-010119-t1x9gknd 9273 16 units unit NNS cord-010119-t1x9gknd 9273 17 were be VBD cord-010119-t1x9gknd 9273 18 tried try VBN cord-010119-t1x9gknd 9273 19 without without IN cord-010119-t1x9gknd 9273 20 success success NN cord-010119-t1x9gknd 9273 21 . . . cord-010119-t1x9gknd 9274 1 At at IN cord-010119-t1x9gknd 9274 2 that that DT cord-010119-t1x9gknd 9274 3 point point NN cord-010119-t1x9gknd 9274 4 , , , cord-010119-t1x9gknd 9274 5 a a DT cord-010119-t1x9gknd 9274 6 CD36 CD36 NNP cord-010119-t1x9gknd 9274 7 Ab Ab NNP cord-010119-t1x9gknd 9274 8 was be VBD cord-010119-t1x9gknd 9274 9 identified identify VBN cord-010119-t1x9gknd 9274 10 in in IN cord-010119-t1x9gknd 9274 11 the the DT cord-010119-t1x9gknd 9274 12 serum serum NN cord-010119-t1x9gknd 9274 13 and and CC cord-010119-t1x9gknd 9274 14 the the DT cord-010119-t1x9gknd 9274 15 patient patient NN cord-010119-t1x9gknd 9274 16 's 's POS cord-010119-t1x9gknd 9274 17 type type NN cord-010119-t1x9gknd 9274 18 1 1 CD cord-010119-t1x9gknd 9274 19 CD36 CD36 NNP cord-010119-t1x9gknd 9274 20 deficiency deficiency NN cord-010119-t1x9gknd 9274 21 was be VBD cord-010119-t1x9gknd 9274 22 confirmed confirm VBN cord-010119-t1x9gknd 9274 23 by by IN cord-010119-t1x9gknd 9274 24 flow flow NN cord-010119-t1x9gknd 9274 25 cytometry cytometry NN cord-010119-t1x9gknd 9274 26 . . . cord-010119-t1x9gknd 9275 1 His -PRON- PRP$ cord-010119-t1x9gknd 9275 2 HLA HLA NNP cord-010119-t1x9gknd 9275 3 class class NN cord-010119-t1x9gknd 9275 4 I -PRON- PRP cord-010119-t1x9gknd 9275 5 Panel Panel NNP cord-010119-t1x9gknd 9275 6 Reactive Reactive NNP cord-010119-t1x9gknd 9275 7 Ab Ab NNP cord-010119-t1x9gknd 9275 8 ( ( -LRB- cord-010119-t1x9gknd 9275 9 PRA PRA NNP cord-010119-t1x9gknd 9275 10 ) ) -RRB- cord-010119-t1x9gknd 9275 11 was be VBD cord-010119-t1x9gknd 9275 12 95 95 CD cord-010119-t1x9gknd 9275 13 % % NN cord-010119-t1x9gknd 9275 14 due due JJ cord-010119-t1x9gknd 9275 15 to to IN cord-010119-t1x9gknd 9275 16 multiple multiple JJ cord-010119-t1x9gknd 9275 17 PLT PLT NNP cord-010119-t1x9gknd 9275 18 transfusions transfusion NNS cord-010119-t1x9gknd 9275 19 , , , cord-010119-t1x9gknd 9275 20 although although IN cord-010119-t1x9gknd 9275 21 all all DT cord-010119-t1x9gknd 9275 22 Abs Abs NNP cord-010119-t1x9gknd 9275 23 were be VBD cord-010119-t1x9gknd 9275 24 low low JJ cord-010119-t1x9gknd 9275 25 levels level NNS cord-010119-t1x9gknd 9275 26 . . . cord-010119-t1x9gknd 9276 1 The the DT cord-010119-t1x9gknd 9276 2 patient patient NN cord-010119-t1x9gknd 9276 3 initially initially RB cord-010119-t1x9gknd 9276 4 received receive VBD cord-010119-t1x9gknd 9276 5 high high JJ cord-010119-t1x9gknd 9276 6 - - HYPH cord-010119-t1x9gknd 9276 7 dose dose NN cord-010119-t1x9gknd 9276 8 prednisone prednisone NN cord-010119-t1x9gknd 9276 9 and and CC cord-010119-t1x9gknd 9276 10 thymocyte thymocyte NNP cord-010119-t1x9gknd 9276 11 immune immune JJ cord-010119-t1x9gknd 9276 12 globulin globulin NN cord-010119-t1x9gknd 9276 13 infusions infusion NNS cord-010119-t1x9gknd 9276 14 without without IN cord-010119-t1x9gknd 9276 15 significant significant JJ cord-010119-t1x9gknd 9276 16 improvement improvement NN cord-010119-t1x9gknd 9276 17 in in IN cord-010119-t1x9gknd 9276 18 PLT PLT NNP cord-010119-t1x9gknd 9276 19 increase increase NN cord-010119-t1x9gknd 9276 20 . . . cord-010119-t1x9gknd 9277 1 Following follow VBG cord-010119-t1x9gknd 9277 2 three three CD cord-010119-t1x9gknd 9277 3 doses dose NNS cord-010119-t1x9gknd 9277 4 of of IN cord-010119-t1x9gknd 9277 5 IVIG IVIG NNP cord-010119-t1x9gknd 9277 6 , , , cord-010119-t1x9gknd 9277 7 he -PRON- PRP cord-010119-t1x9gknd 9277 8 received receive VBD cord-010119-t1x9gknd 9277 9 a a DT cord-010119-t1x9gknd 9277 10 CD-36 CD-36 NNP cord-010119-t1x9gknd 9277 11 negative negative JJ cord-010119-t1x9gknd 9277 12 ( ( -LRB- cord-010119-t1x9gknd 9277 13 but but CC cord-010119-t1x9gknd 9277 14 blood blood NN cord-010119-t1x9gknd 9277 15 type type NN cord-010119-t1x9gknd 9277 16 different different JJ cord-010119-t1x9gknd 9277 17 and and CC cord-010119-t1x9gknd 9277 18 HLA HLA NNP cord-010119-t1x9gknd 9277 19 187A 187a CD cord-010119-t1x9gknd 9277 20 TRANSFUSION transfusion NN cord-010119-t1x9gknd 9277 21 2017 2017 CD cord-010119-t1x9gknd 9277 22 Vol Vol NNP cord-010119-t1x9gknd 9277 23 . . . cord-010119-t1x9gknd 9278 1 57 57 CD cord-010119-t1x9gknd 9278 2 Supplement supplement NN cord-010119-t1x9gknd 9278 3 S3 S3 NNP cord-010119-t1x9gknd 9278 4 unmatched unmatched NN cord-010119-t1x9gknd 9278 5 ) ) -RRB- cord-010119-t1x9gknd 9279 1 PLT PLT NNP cord-010119-t1x9gknd 9279 2 unit unit NN cord-010119-t1x9gknd 9279 3 from from IN cord-010119-t1x9gknd 9279 4 his -PRON- PRP$ cord-010119-t1x9gknd 9279 5 relative relative NN cord-010119-t1x9gknd 9279 6 with with IN cord-010119-t1x9gknd 9279 7 only only RB cord-010119-t1x9gknd 9279 8 a a DT cord-010119-t1x9gknd 9279 9 slight slight JJ cord-010119-t1x9gknd 9279 10 increase increase NN cord-010119-t1x9gknd 9279 11 in in IN cord-010119-t1x9gknd 9279 12 PLT PLT NNP cord-010119-t1x9gknd 9279 13 count count NN cord-010119-t1x9gknd 9279 14 . . . cord-010119-t1x9gknd 9280 1 However however RB cord-010119-t1x9gknd 9280 2 , , , cord-010119-t1x9gknd 9280 3 he -PRON- PRP cord-010119-t1x9gknd 9280 4 started start VBD cord-010119-t1x9gknd 9280 5 to to TO cord-010119-t1x9gknd 9280 6 respond respond VB cord-010119-t1x9gknd 9280 7 to to IN cord-010119-t1x9gknd 9280 8 CD36 CD36 NNP cord-010119-t1x9gknd 9280 9 non non JJ cord-010119-t1x9gknd 9280 10 - - JJ cord-010119-t1x9gknd 9280 11 tested tested JJ cord-010119-t1x9gknd 9280 12 apheresis apheresis NN cord-010119-t1x9gknd 9280 13 PLTs plt NNS cord-010119-t1x9gknd 9280 14 after after IN cord-010119-t1x9gknd 9280 15 receiving receive VBG cord-010119-t1x9gknd 9280 16 a a DT cord-010119-t1x9gknd 9280 17 fourth fourth JJ cord-010119-t1x9gknd 9280 18 IVIG IVIG NNP cord-010119-t1x9gknd 9280 19 and and CC cord-010119-t1x9gknd 9280 20 two two CD cord-010119-t1x9gknd 9280 21 rituximab rituximab JJ cord-010119-t1x9gknd 9280 22 infusions infusion NNS cord-010119-t1x9gknd 9280 23 . . . cord-010119-t1x9gknd 9281 1 Since since IN cord-010119-t1x9gknd 9281 2 then then RB cord-010119-t1x9gknd 9281 3 , , , cord-010119-t1x9gknd 9281 4 he -PRON- PRP cord-010119-t1x9gknd 9281 5 has have VBZ cord-010119-t1x9gknd 9281 6 received receive VBN cord-010119-t1x9gknd 9281 7 IVIG IVIG NNP cord-010119-t1x9gknd 9281 8 every every DT cord-010119-t1x9gknd 9281 9 2 2 CD cord-010119-t1x9gknd 9281 10 weeks week NNS cord-010119-t1x9gknd 9281 11 . . . cord-010119-t1x9gknd 9282 1 Other other JJ cord-010119-t1x9gknd 9282 2 medications medication NNS cord-010119-t1x9gknd 9282 3 include include VBP cord-010119-t1x9gknd 9282 4 filgrastim filgrastim NN cord-010119-t1x9gknd 9282 5 , , , cord-010119-t1x9gknd 9282 6 eltrombopag eltrombopag NNP cord-010119-t1x9gknd 9282 7 , , , cord-010119-t1x9gknd 9282 8 and and CC cord-010119-t1x9gknd 9282 9 cyclosporine cyclosporine NN cord-010119-t1x9gknd 9282 10 for for IN cord-010119-t1x9gknd 9282 11 treatment treatment NN cord-010119-t1x9gknd 9282 12 of of IN cord-010119-t1x9gknd 9282 13 aplastic aplastic JJ cord-010119-t1x9gknd 9282 14 anemia anemia NN cord-010119-t1x9gknd 9282 15 . . . cord-010119-t1x9gknd 9283 1 The the DT cord-010119-t1x9gknd 9283 2 mean mean NN cord-010119-t1x9gknd 9283 3 corrected correct VBD cord-010119-t1x9gknd 9283 4 count count NN cord-010119-t1x9gknd 9283 5 increments increment NNS cord-010119-t1x9gknd 9283 6 ( ( -LRB- cord-010119-t1x9gknd 9283 7 CCI CCI NNP cord-010119-t1x9gknd 9283 8 ) ) -RRB- cord-010119-t1x9gknd 9283 9 when when WRB cord-010119-t1x9gknd 9283 10 post post JJ cord-010119-t1x9gknd 9283 11 - - JJ cord-010119-t1x9gknd 9283 12 transfusion transfusion NN cord-010119-t1x9gknd 9283 13 PLT PLT NNP cord-010119-t1x9gknd 9283 14 count count NN cord-010119-t1x9gknd 9283 15 was be VBD cord-010119-t1x9gknd 9283 16 available available JJ cord-010119-t1x9gknd 9283 17 are be VBP cord-010119-t1x9gknd 9283 18 shown show VBN cord-010119-t1x9gknd 9283 19 in in IN cord-010119-t1x9gknd 9283 20 Table Table NNP cord-010119-t1x9gknd 9283 21 . . . cord-010119-t1x9gknd 9284 1 With with IN cord-010119-t1x9gknd 9284 2 desensitization desensitization NN cord-010119-t1x9gknd 9284 3 therapy therapy NN cord-010119-t1x9gknd 9284 4 , , , cord-010119-t1x9gknd 9284 5 his -PRON- PRP$ cord-010119-t1x9gknd 9284 6 CD36 CD36 NNP cord-010119-t1x9gknd 9284 7 antibody antibody NN cord-010119-t1x9gknd 9284 8 positive positive JJ cord-010119-t1x9gknd 9284 9 reactivity reactivity NN cord-010119-t1x9gknd 9284 10 in in IN cord-010119-t1x9gknd 9284 11 serial serial JJ cord-010119-t1x9gknd 9284 12 dilutions dilution NNS cord-010119-t1x9gknd 9284 13 has have VBZ cord-010119-t1x9gknd 9284 14 reduced reduce VBN cord-010119-t1x9gknd 9284 15 from from IN cord-010119-t1x9gknd 9284 16 1:32 1:32 CD cord-010119-t1x9gknd 9284 17 to to IN cord-010119-t1x9gknd 9284 18 1:2 1:2 CD cord-010119-t1x9gknd 9284 19 dilutions dilution NNS cord-010119-t1x9gknd 9284 20 and and CC cord-010119-t1x9gknd 9284 21 his -PRON- PRP$ cord-010119-t1x9gknd 9284 22 HLA HLA NNP cord-010119-t1x9gknd 9284 23 Class Class NNP cord-010119-t1x9gknd 9284 24 I I NNP cord-010119-t1x9gknd 9284 25 PRA PRA NNP cord-010119-t1x9gknd 9284 26 has have VBZ cord-010119-t1x9gknd 9284 27 decreased decrease VBN cord-010119-t1x9gknd 9284 28 to to IN cord-010119-t1x9gknd 9284 29 37 37 CD cord-010119-t1x9gknd 9284 30 % % NN cord-010119-t1x9gknd 9284 31 . . . cord-010119-t1x9gknd 9285 1 He -PRON- PRP cord-010119-t1x9gknd 9285 2 is be VBZ cord-010119-t1x9gknd 9285 3 currently currently RB cord-010119-t1x9gknd 9285 4 receiving receive VBG cord-010119-t1x9gknd 9285 5 2 2 CD cord-010119-t1x9gknd 9285 6 apheresis apheresis NN cord-010119-t1x9gknd 9285 7 PLT PLT NNP cord-010119-t1x9gknd 9285 8 units unit NNS cord-010119-t1x9gknd 9285 9 twice twice RB cord-010119-t1x9gknd 9285 10 a a DT cord-010119-t1x9gknd 9285 11 week week NN cord-010119-t1x9gknd 9285 12 and and CC cord-010119-t1x9gknd 9285 13 RBC RBC NNP cord-010119-t1x9gknd 9285 14 units unit NNS cord-010119-t1x9gknd 9285 15 periodically periodically RB cord-010119-t1x9gknd 9285 16 . . . cord-010119-t1x9gknd 9286 1 His -PRON- PRP$ cord-010119-t1x9gknd 9286 2 bone bone NN cord-010119-t1x9gknd 9286 3 marrow marrow NN cord-010119-t1x9gknd 9286 4 ( ( -LRB- cord-010119-t1x9gknd 9286 5 BM BM NNP cord-010119-t1x9gknd 9286 6 ) ) -RRB- cord-010119-t1x9gknd 9286 7 has have VBZ cord-010119-t1x9gknd 9286 8 been be VBN cord-010119-t1x9gknd 9286 9 slowly slowly RB cord-010119-t1x9gknd 9286 10 recovering recover VBG cord-010119-t1x9gknd 9286 11 evidenced evidence VBN cord-010119-t1x9gknd 9286 12 by by IN cord-010119-t1x9gknd 9286 13 increased increase VBN cord-010119-t1x9gknd 9286 14 WBC WBC NNP cord-010119-t1x9gknd 9286 15 count count NN cord-010119-t1x9gknd 9286 16 from from IN cord-010119-t1x9gknd 9286 17 zero zero CD cord-010119-t1x9gknd 9286 18 to to IN cord-010119-t1x9gknd 9286 19 up up IN cord-010119-t1x9gknd 9286 20 to to TO cord-010119-t1x9gknd 9286 21 1.0 1.0 CD cord-010119-t1x9gknd 9286 22 K k NN cord-010119-t1x9gknd 9286 23 / / SYM cord-010119-t1x9gknd 9286 24 mL ml NN cord-010119-t1x9gknd 9286 25 and and CC cord-010119-t1x9gknd 9286 26 slow slow JJ cord-010119-t1x9gknd 9286 27 increase increase NN cord-010119-t1x9gknd 9286 28 of of IN cord-010119-t1x9gknd 9286 29 reticulocyte reticulocyte NN cord-010119-t1x9gknd 9286 30 counts count NNS cord-010119-t1x9gknd 9286 31 . . . cord-010119-t1x9gknd 9287 1 Current current JJ cord-010119-t1x9gknd 9287 2 plan plan NN cord-010119-t1x9gknd 9287 3 is be VBZ cord-010119-t1x9gknd 9287 4 RBC RBC NNP cord-010119-t1x9gknd 9287 5 / / SYM cord-010119-t1x9gknd 9287 6 PLT PLT NNP cord-010119-t1x9gknd 9287 7 transfusion transfusion NN cord-010119-t1x9gknd 9287 8 support support NN cord-010119-t1x9gknd 9287 9 until until IN cord-010119-t1x9gknd 9287 10 BM BM NNP cord-010119-t1x9gknd 9287 11 recovers recover VBZ cord-010119-t1x9gknd 9287 12 or or CC cord-010119-t1x9gknd 9287 13 a a DT cord-010119-t1x9gknd 9287 14 haplo haplo NN cord-010119-t1x9gknd 9287 15 - - HYPH cord-010119-t1x9gknd 9287 16 identical identical JJ cord-010119-t1x9gknd 9287 17 transplant transplant NN cord-010119-t1x9gknd 9287 18 if if IN cord-010119-t1x9gknd 9287 19 BM BM NNP cord-010119-t1x9gknd 9287 20 recovery recovery NN cord-010119-t1x9gknd 9287 21 fails fail VBZ cord-010119-t1x9gknd 9287 22 . . . cord-010119-t1x9gknd 9288 1 Conclusion conclusion NN cord-010119-t1x9gknd 9288 2 : : : cord-010119-t1x9gknd 9288 3 We -PRON- PRP cord-010119-t1x9gknd 9288 4 report report VBP cord-010119-t1x9gknd 9288 5 a a DT cord-010119-t1x9gknd 9288 6 case case NN cord-010119-t1x9gknd 9288 7 with with IN cord-010119-t1x9gknd 9288 8 anti anti JJ cord-010119-t1x9gknd 9288 9 - - JJ cord-010119-t1x9gknd 9288 10 CD36 CD36 NNP cord-010119-t1x9gknd 9288 11 Abs Abs NNP cord-010119-t1x9gknd 9288 12 that that WDT cord-010119-t1x9gknd 9288 13 received receive VBD cord-010119-t1x9gknd 9288 14 multiple multiple JJ cord-010119-t1x9gknd 9288 15 PLT PLT NNP cord-010119-t1x9gknd 9288 16 transfusions transfusion NNS cord-010119-t1x9gknd 9288 17 . . . cord-010119-t1x9gknd 9289 1 This this DT cord-010119-t1x9gknd 9289 2 case case NN cord-010119-t1x9gknd 9289 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 9289 4 that that IN cord-010119-t1x9gknd 9289 5 decreasing decrease VBG cord-010119-t1x9gknd 9289 6 Ab Ab NNP cord-010119-t1x9gknd 9289 7 level level NN cord-010119-t1x9gknd 9289 8 with with IN cord-010119-t1x9gknd 9289 9 immunomodulation immunomodulation NN cord-010119-t1x9gknd 9289 10 can can MD cord-010119-t1x9gknd 9289 11 be be VB cord-010119-t1x9gknd 9289 12 an an DT cord-010119-t1x9gknd 9289 13 alternative alternative JJ cord-010119-t1x9gknd 9289 14 option option NN cord-010119-t1x9gknd 9289 15 for for IN cord-010119-t1x9gknd 9289 16 successful successful JJ cord-010119-t1x9gknd 9289 17 PLT PLT NNP cord-010119-t1x9gknd 9289 18 transfusion transfusion NN cord-010119-t1x9gknd 9289 19 when when WRB cord-010119-t1x9gknd 9289 20 compatible compatible JJ cord-010119-t1x9gknd 9289 21 PLTs plt NNS cord-010119-t1x9gknd 9289 22 are be VBP cord-010119-t1x9gknd 9289 23 not not RB cord-010119-t1x9gknd 9289 24 available available JJ cord-010119-t1x9gknd 9289 25 for for IN cord-010119-t1x9gknd 9289 26 patients patient NNS cord-010119-t1x9gknd 9289 27 with with IN cord-010119-t1x9gknd 9289 28 rare rare JJ cord-010119-t1x9gknd 9289 29 or or CC cord-010119-t1x9gknd 9289 30 multiple multiple JJ cord-010119-t1x9gknd 9289 31 Abs abs NN cord-010119-t1x9gknd 9289 32 to to IN cord-010119-t1x9gknd 9289 33 PLTs plt NNS cord-010119-t1x9gknd 9289 34 . . . cord-010119-t1x9gknd 9290 1 Table table NN cord-010119-t1x9gknd 9290 2 : : : cord-010119-t1x9gknd 9291 1 Mean mean JJ cord-010119-t1x9gknd 9291 2 available available JJ cord-010119-t1x9gknd 9291 3 CCI CCI NNP cord-010119-t1x9gknd 9291 4 for for IN cord-010119-t1x9gknd 9292 1 PLT PLT NNP cord-010119-t1x9gknd 9292 2 Transfusions Transfusions NNPS cord-010119-t1x9gknd 9292 3 A A NNP cord-010119-t1x9gknd 9292 4 Blood Blood NNP cord-010119-t1x9gknd 9292 5 Center Center NNP cord-010119-t1x9gknd 9292 6 's 's POS cord-010119-t1x9gknd 9292 7 Experience experience NN cord-010119-t1x9gknd 9292 8 Screening screen VBG cord-010119-t1x9gknd 9292 9 Donations donation NNS cord-010119-t1x9gknd 9292 10 for for IN cord-010119-t1x9gknd 9292 11 Babesia Babesia NNP cord-010119-t1x9gknd 9292 12 Microti Microti NNP cord-010119-t1x9gknd 9293 1 Using use VBG cord-010119-t1x9gknd 9293 2 Enzyme Enzyme NNP cord-010119-t1x9gknd 9293 3 - - HYPH cord-010119-t1x9gknd 9293 4 Linked link VBN cord-010119-t1x9gknd 9293 5 Immunoassay Immunoassay NNP cord-010119-t1x9gknd 9293 6 Methodology Methodology NNP cord-010119-t1x9gknd 9293 7 Nancy Nancy NNP cord-010119-t1x9gknd 9293 8 Van Van NNP cord-010119-t1x9gknd 9293 9 Buren Buren NNP cord-010119-t1x9gknd 9293 10 * * NFP cord-010119-t1x9gknd 9293 11 , , , cord-010119-t1x9gknd 9293 12 Jed Jed NNP cord-010119-t1x9gknd 9293 13 Gorlin Gorlin NNP cord-010119-t1x9gknd 9293 14 , , , cord-010119-t1x9gknd 9293 15 Vanessa Vanessa NNP cord-010119-t1x9gknd 9293 16 Reynolds Reynolds NNP cord-010119-t1x9gknd 9293 17 and and CC cord-010119-t1x9gknd 9293 18 Deborah Deborah NNP cord-010119-t1x9gknd 9293 19 Anderson Anderson NNP cord-010119-t1x9gknd 9293 20 . . . cord-010119-t1x9gknd 9294 1 Background Background NNP cord-010119-t1x9gknd 9294 2 / / SYM cord-010119-t1x9gknd 9294 3 Case Case NNP cord-010119-t1x9gknd 9294 4 Studies Studies NNPS cord-010119-t1x9gknd 9294 5 : : : cord-010119-t1x9gknd 9295 1 Our -PRON- PRP$ cord-010119-t1x9gknd 9295 2 blood blood NN cord-010119-t1x9gknd 9295 3 center center NN cord-010119-t1x9gknd 9295 4 , , , cord-010119-t1x9gknd 9295 5 located locate VBN cord-010119-t1x9gknd 9295 6 in in IN cord-010119-t1x9gknd 9295 7 an an DT cord-010119-t1x9gknd 9295 8 area area NN cord-010119-t1x9gknd 9295 9 considered consider VBN cord-010119-t1x9gknd 9295 10 to to TO cord-010119-t1x9gknd 9295 11 be be VB cord-010119-t1x9gknd 9295 12 moderately moderately RB cord-010119-t1x9gknd 9295 13 endemic endemic JJ cord-010119-t1x9gknd 9295 14 for for IN cord-010119-t1x9gknd 9295 15 Babesia Babesia NNP cord-010119-t1x9gknd 9295 16 microti microti NN cord-010119-t1x9gknd 9295 17 , , , cord-010119-t1x9gknd 9295 18 implemented implement VBD cord-010119-t1x9gknd 9295 19 universal universal JJ cord-010119-t1x9gknd 9295 20 screening screening NN cord-010119-t1x9gknd 9295 21 of of IN cord-010119-t1x9gknd 9295 22 red red JJ cord-010119-t1x9gknd 9295 23 cell cell NN cord-010119-t1x9gknd 9295 24 collections collection NNS cord-010119-t1x9gknd 9295 25 from from IN cord-010119-t1x9gknd 9295 26 Minnesota Minnesota NNP cord-010119-t1x9gknd 9295 27 and and CC cord-010119-t1x9gknd 9295 28 Wisconsin Wisconsin NNP cord-010119-t1x9gknd 9295 29 under under IN cord-010119-t1x9gknd 9295 30 an an DT cord-010119-t1x9gknd 9295 31 investigation investigation NN cord-010119-t1x9gknd 9295 32 new new JJ cord-010119-t1x9gknd 9295 33 drug drug NN cord-010119-t1x9gknd 9295 34 ( ( -LRB- cord-010119-t1x9gknd 9295 35 IND IND NNP cord-010119-t1x9gknd 9295 36 ) ) -RRB- cord-010119-t1x9gknd 9295 37 study study NN cord-010119-t1x9gknd 9295 38 in in IN cord-010119-t1x9gknd 9295 39 Oct Oct NNP cord-010119-t1x9gknd 9295 40 2015 2015 CD cord-010119-t1x9gknd 9295 41 utilizing utilize VBG cord-010119-t1x9gknd 9295 42 the the DT cord-010119-t1x9gknd 9295 43 Immunetics Immunetics NNP cord-010119-t1x9gknd 9295 44 investigational investigational JJ cord-010119-t1x9gknd 9295 45 enzyme enzyme NN cord-010119-t1x9gknd 9295 46 - - HYPH cord-010119-t1x9gknd 9295 47 linked link VBN cord-010119-t1x9gknd 9295 48 immunoassay immunoassay NN cord-010119-t1x9gknd 9295 49 ( ( -LRB- cord-010119-t1x9gknd 9295 50 ELISA ELISA NNP cord-010119-t1x9gknd 9295 51 ) ) -RRB- cord-010119-t1x9gknd 9295 52 performed perform VBN cord-010119-t1x9gknd 9295 53 by by IN cord-010119-t1x9gknd 9295 54 Creative Creative NNP cord-010119-t1x9gknd 9295 55 Testing Testing NNP cord-010119-t1x9gknd 9295 56 Solutions Solutions NNPS cord-010119-t1x9gknd 9295 57 ( ( -LRB- cord-010119-t1x9gknd 9295 58 CTS CTS NNP cord-010119-t1x9gknd 9295 59 ) ) -RRB- cord-010119-t1x9gknd 9295 60 . . . cord-010119-t1x9gknd 9296 1 This this DT cord-010119-t1x9gknd 9296 2 test test NN cord-010119-t1x9gknd 9296 3 was be VBD cord-010119-t1x9gknd 9296 4 selected select VBN cord-010119-t1x9gknd 9296 5 as as IN cord-010119-t1x9gknd 9296 6 the the DT cord-010119-t1x9gknd 9296 7 most most RBS cord-010119-t1x9gknd 9296 8 cost cost NN cord-010119-t1x9gknd 9296 9 - - HYPH cord-010119-t1x9gknd 9296 10 effective effective JJ cord-010119-t1x9gknd 9296 11 approach approach NN cord-010119-t1x9gknd 9296 12 for for IN cord-010119-t1x9gknd 9296 13 universal universal JJ cord-010119-t1x9gknd 9296 14 screening screening NN cord-010119-t1x9gknd 9296 15 of of IN cord-010119-t1x9gknd 9296 16 blood blood NN cord-010119-t1x9gknd 9296 17 donors donor NNS cord-010119-t1x9gknd 9296 18 , , , cord-010119-t1x9gknd 9296 19 as as IN cord-010119-t1x9gknd 9296 20 opposed oppose VBN cord-010119-t1x9gknd 9296 21 to to IN cord-010119-t1x9gknd 9296 22 the the DT cord-010119-t1x9gknd 9296 23 investigational investigational JJ cord-010119-t1x9gknd 9296 24 IFA IFA NNP cord-010119-t1x9gknd 9296 25 / / SYM cord-010119-t1x9gknd 9296 26 PCR PCR NNP cord-010119-t1x9gknd 9296 27 test test NN cord-010119-t1x9gknd 9296 28 combination combination NN cord-010119-t1x9gknd 9296 29 . . . cord-010119-t1x9gknd 9297 1 Study Study NNP cord-010119-t1x9gknd 9297 2 Design Design NNP cord-010119-t1x9gknd 9297 3 / / SYM cord-010119-t1x9gknd 9297 4 Methods method NNS cord-010119-t1x9gknd 9298 1 : : : cord-010119-t1x9gknd 9298 2 We -PRON- PRP cord-010119-t1x9gknd 9298 3 performed perform VBD cord-010119-t1x9gknd 9298 4 a a DT cord-010119-t1x9gknd 9298 5 retrospective retrospective JJ cord-010119-t1x9gknd 9298 6 analysis analysis NN cord-010119-t1x9gknd 9298 7 of of IN cord-010119-t1x9gknd 9298 8 our -PRON- PRP$ cord-010119-t1x9gknd 9298 9 screening screening NN cord-010119-t1x9gknd 9298 10 test test NN cord-010119-t1x9gknd 9298 11 results result NNS cord-010119-t1x9gknd 9298 12 and and CC cord-010119-t1x9gknd 9298 13 deferral deferral NN cord-010119-t1x9gknd 9298 14 rates rate NNS cord-010119-t1x9gknd 9298 15 for for IN cord-010119-t1x9gknd 9298 16 2016 2016 CD cord-010119-t1x9gknd 9298 17 to to TO cord-010119-t1x9gknd 9298 18 evaluate evaluate VB cord-010119-t1x9gknd 9298 19 for for IN cord-010119-t1x9gknd 9298 20 seasonality seasonality NN cord-010119-t1x9gknd 9298 21 , , , cord-010119-t1x9gknd 9298 22 donor donor NN cord-010119-t1x9gknd 9298 23 ABO ABO NNP cord-010119-t1x9gknd 9298 24 bias bias NN cord-010119-t1x9gknd 9298 25 , , , cord-010119-t1x9gknd 9298 26 deferral deferral NN cord-010119-t1x9gknd 9298 27 rates rate NNS cord-010119-t1x9gknd 9298 28 , , , cord-010119-t1x9gknd 9298 29 and and CC cord-010119-t1x9gknd 9298 30 outcomes outcome NNS cord-010119-t1x9gknd 9298 31 of of IN cord-010119-t1x9gknd 9298 32 lookback lookback JJ cord-010119-t1x9gknd 9298 33 investigations investigation NNS cord-010119-t1x9gknd 9298 34 . . . cord-010119-t1x9gknd 9299 1 Since since IN cord-010119-t1x9gknd 9299 2 an an DT cord-010119-t1x9gknd 9299 3 opt opt NN cord-010119-t1x9gknd 9299 4 - - HYPH cord-010119-t1x9gknd 9299 5 out out NN cord-010119-t1x9gknd 9299 6 of of IN cord-010119-t1x9gknd 9299 7 this this DT cord-010119-t1x9gknd 9299 8 research research NN cord-010119-t1x9gknd 9299 9 test test NN cord-010119-t1x9gknd 9299 10 was be VBD cord-010119-t1x9gknd 9299 11 originally originally RB cord-010119-t1x9gknd 9299 12 offered offer VBN cord-010119-t1x9gknd 9299 13 , , , cord-010119-t1x9gknd 9299 14 we -PRON- PRP cord-010119-t1x9gknd 9299 15 report report VBP cord-010119-t1x9gknd 9299 16 donor donor NN cord-010119-t1x9gknd 9299 17 opt opt NN cord-010119-t1x9gknd 9299 18 - - HYPH cord-010119-t1x9gknd 9299 19 out out RP cord-010119-t1x9gknd 9299 20 rates rate NNS cord-010119-t1x9gknd 9299 21 . . . cord-010119-t1x9gknd 9300 1 Results result NNS cord-010119-t1x9gknd 9300 2 / / SYM cord-010119-t1x9gknd 9300 3 Findings finding NNS cord-010119-t1x9gknd 9300 4 : : : cord-010119-t1x9gknd 9301 1 From from IN cord-010119-t1x9gknd 9301 2 Jan Jan NNP cord-010119-t1x9gknd 9301 3 through through IN cord-010119-t1x9gknd 9301 4 Dec Dec NNP cord-010119-t1x9gknd 9301 5 2016 2016 CD cord-010119-t1x9gknd 9301 6 , , , cord-010119-t1x9gknd 9301 7 101,854 101,854 CD cord-010119-t1x9gknd 9301 8 blood blood NN cord-010119-t1x9gknd 9301 9 donations donation NNS cord-010119-t1x9gknd 9301 10 were be VBD cord-010119-t1x9gknd 9301 11 screened screen VBN cord-010119-t1x9gknd 9301 12 for for IN cord-010119-t1x9gknd 9301 13 B b NN cord-010119-t1x9gknd 9301 14 microti microti NN cord-010119-t1x9gknd 9301 15 by by IN cord-010119-t1x9gknd 9301 16 Immunetics Immunetics NNP cord-010119-t1x9gknd 9301 17 ELISA ELISA NNP cord-010119-t1x9gknd 9301 18 . . . cord-010119-t1x9gknd 9302 1 Of of IN cord-010119-t1x9gknd 9302 2 those those DT cord-010119-t1x9gknd 9302 3 , , , cord-010119-t1x9gknd 9302 4 267 267 CD cord-010119-t1x9gknd 9302 5 ( ( -LRB- cord-010119-t1x9gknd 9302 6 0.26 0.26 CD cord-010119-t1x9gknd 9302 7 % % NN cord-010119-t1x9gknd 9302 8 ) ) -RRB- cord-010119-t1x9gknd 9302 9 were be VBD cord-010119-t1x9gknd 9302 10 positive positive JJ cord-010119-t1x9gknd 9302 11 . . . cord-010119-t1x9gknd 9303 1 The the DT cord-010119-t1x9gknd 9303 2 percent percent NN cord-010119-t1x9gknd 9303 3 of of IN cord-010119-t1x9gknd 9303 4 positive positive JJ cord-010119-t1x9gknd 9303 5 donations donation NNS cord-010119-t1x9gknd 9303 6 was be VBD cord-010119-t1x9gknd 9303 7 evaluated evaluate VBN cord-010119-t1x9gknd 9303 8 monthly monthly RB cord-010119-t1x9gknd 9303 9 revealing reveal VBG cord-010119-t1x9gknd 9303 10 a a DT cord-010119-t1x9gknd 9303 11 variable variable JJ cord-010119-t1x9gknd 9303 12 reaction reaction NN cord-010119-t1x9gknd 9303 13 rate rate NN cord-010119-t1x9gknd 9303 14 between between IN cord-010119-t1x9gknd 9303 15 0.08 0.08 CD cord-010119-t1x9gknd 9303 16 % % NN cord-010119-t1x9gknd 9303 17 and and CC cord-010119-t1x9gknd 9303 18 0.42 0.42 CD cord-010119-t1x9gknd 9303 19 % % NN cord-010119-t1x9gknd 9303 20 . . . cord-010119-t1x9gknd 9304 1 No no DT cord-010119-t1x9gknd 9304 2 patient patient JJ cord-010119-t1x9gknd 9304 3 Babesia Babesia NNP cord-010119-t1x9gknd 9304 4 transmission transmission NN cord-010119-t1x9gknd 9304 5 has have VBZ cord-010119-t1x9gknd 9304 6 been be VBN cord-010119-t1x9gknd 9304 7 reported report VBN cord-010119-t1x9gknd 9304 8 since since IN cord-010119-t1x9gknd 9304 9 implementing implement VBG cord-010119-t1x9gknd 9304 10 this this DT cord-010119-t1x9gknd 9304 11 test test NN cord-010119-t1x9gknd 9304 12 , , , cord-010119-t1x9gknd 9304 13 but but CC cord-010119-t1x9gknd 9304 14 we -PRON- PRP cord-010119-t1x9gknd 9304 15 only only RB cord-010119-t1x9gknd 9304 16 had have VBD cord-010119-t1x9gknd 9304 17 4 4 CD cord-010119-t1x9gknd 9304 18 documented document VBN cord-010119-t1x9gknd 9304 19 Babesia Babesia NNP cord-010119-t1x9gknd 9304 20 TTD TTD NNP cord-010119-t1x9gknd 9304 21 cases case NNS cord-010119-t1x9gknd 9304 22 from from IN cord-010119-t1x9gknd 9304 23 2007 2007 CD cord-010119-t1x9gknd 9304 24 - - SYM cord-010119-t1x9gknd 9304 25 2017 2017 CD cord-010119-t1x9gknd 9304 26 . . . cord-010119-t1x9gknd 9305 1 Donors donor NNS cord-010119-t1x9gknd 9305 2 who who WP cord-010119-t1x9gknd 9305 3 previously previously RB cord-010119-t1x9gknd 9305 4 tested test VBD cord-010119-t1x9gknd 9305 5 negative negative RB cord-010119-t1x9gknd 9305 6 demonstrated demonstrate VBD cord-010119-t1x9gknd 9305 7 an an DT cord-010119-t1x9gknd 9305 8 increased increase VBN cord-010119-t1x9gknd 9305 9 seroconversion seroconversion NN cord-010119-t1x9gknd 9305 10 rate rate NN cord-010119-t1x9gknd 9305 11 during during IN cord-010119-t1x9gknd 9305 12 the the DT cord-010119-t1x9gknd 9305 13 summer summer NN cord-010119-t1x9gknd 9305 14 months month NNS cord-010119-t1x9gknd 9305 15 , , , cord-010119-t1x9gknd 9305 16 consistent consistent JJ cord-010119-t1x9gknd 9305 17 with with IN cord-010119-t1x9gknd 9305 18 historical historical JJ cord-010119-t1x9gknd 9305 19 seasonal seasonal JJ cord-010119-t1x9gknd 9305 20 variation variation NN cord-010119-t1x9gknd 9305 21 corresponding correspond VBG cord-010119-t1x9gknd 9305 22 with with IN cord-010119-t1x9gknd 9305 23 tick tick NN cord-010119-t1x9gknd 9305 24 season season NN cord-010119-t1x9gknd 9305 25 in in IN cord-010119-t1x9gknd 9305 26 Minnesota Minnesota NNP cord-010119-t1x9gknd 9305 27 and and CC cord-010119-t1x9gknd 9305 28 Wisconsin Wisconsin NNP cord-010119-t1x9gknd 9305 29 . . . cord-010119-t1x9gknd 9306 1 Test test NN cord-010119-t1x9gknd 9306 2 performance performance NN cord-010119-t1x9gknd 9306 3 characteristics characteristic NNS cord-010119-t1x9gknd 9306 4 were be VBD cord-010119-t1x9gknd 9306 5 analyzed analyze VBN cord-010119-t1x9gknd 9306 6 by by IN cord-010119-t1x9gknd 9306 7 ABO ABO NNP cord-010119-t1x9gknd 9306 8 group group NN cord-010119-t1x9gknd 9306 9 with with IN cord-010119-t1x9gknd 9306 10 no no DT cord-010119-t1x9gknd 9306 11 demonstrable demonstrable JJ cord-010119-t1x9gknd 9306 12 differences difference NNS cord-010119-t1x9gknd 9306 13 in in IN cord-010119-t1x9gknd 9306 14 positive positive JJ cord-010119-t1x9gknd 9306 15 rates rate NNS cord-010119-t1x9gknd 9306 16 . . . cord-010119-t1x9gknd 9307 1 The the DT cord-010119-t1x9gknd 9307 2 opt opt NN cord-010119-t1x9gknd 9307 3 - - HYPH cord-010119-t1x9gknd 9307 4 out out RP cord-010119-t1x9gknd 9307 5 rate rate NN cord-010119-t1x9gknd 9307 6 of of IN cord-010119-t1x9gknd 9307 7 donors donor NNS cord-010119-t1x9gknd 9307 8 who who WP cord-010119-t1x9gknd 9307 9 chose choose VBD cord-010119-t1x9gknd 9307 10 not not RB cord-010119-t1x9gknd 9307 11 to to TO cord-010119-t1x9gknd 9307 12 be be VB cord-010119-t1x9gknd 9307 13 tested test VBN cord-010119-t1x9gknd 9307 14 significantly significantly RB cord-010119-t1x9gknd 9307 15 decreased decrease VBD cord-010119-t1x9gknd 9307 16 over over IN cord-010119-t1x9gknd 9307 17 time time NN cord-010119-t1x9gknd 9307 18 , , , cord-010119-t1x9gknd 9307 19 reflecting reflect VBG cord-010119-t1x9gknd 9307 20 an an DT cord-010119-t1x9gknd 9307 21 increased increase VBN cord-010119-t1x9gknd 9307 22 acceptance acceptance NN cord-010119-t1x9gknd 9307 23 of of IN cord-010119-t1x9gknd 9307 24 this this DT cord-010119-t1x9gknd 9307 25 test test NN cord-010119-t1x9gknd 9307 26 . . . cord-010119-t1x9gknd 9308 1 Of of IN cord-010119-t1x9gknd 9308 2 267 267 CD cord-010119-t1x9gknd 9308 3 positive positive JJ cord-010119-t1x9gknd 9308 4 test test NN cord-010119-t1x9gknd 9308 5 results result NNS cord-010119-t1x9gknd 9308 6 , , , cord-010119-t1x9gknd 9308 7 160 160 CD cord-010119-t1x9gknd 9308 8 lookback lookback JJ cord-010119-t1x9gknd 9308 9 investigations investigation NNS cord-010119-t1x9gknd 9308 10 were be VBD cord-010119-t1x9gknd 9308 11 initiated initiate VBN cord-010119-t1x9gknd 9308 12 representing represent VBG cord-010119-t1x9gknd 9308 13 59 59 CD cord-010119-t1x9gknd 9308 14 % % NN cord-010119-t1x9gknd 9308 15 of of IN cord-010119-t1x9gknd 9308 16 positive positive JJ cord-010119-t1x9gknd 9308 17 donations donation NNS cord-010119-t1x9gknd 9308 18 . . . cord-010119-t1x9gknd 9309 1 Lookbacks lookback NNS cord-010119-t1x9gknd 9309 2 were be VBD cord-010119-t1x9gknd 9309 3 only only RB cord-010119-t1x9gknd 9309 4 performed perform VBN cord-010119-t1x9gknd 9309 5 when when WRB cord-010119-t1x9gknd 9309 6 there there EX cord-010119-t1x9gknd 9309 7 was be VBD cord-010119-t1x9gknd 9309 8 a a DT cord-010119-t1x9gknd 9309 9 donation donation NN cord-010119-t1x9gknd 9309 10 within within IN cord-010119-t1x9gknd 9309 11 12 12 CD cord-010119-t1x9gknd 9309 12 months month NNS cord-010119-t1x9gknd 9309 13 of of IN cord-010119-t1x9gknd 9309 14 the the DT cord-010119-t1x9gknd 9309 15 new new JJ cord-010119-t1x9gknd 9309 16 positive positive JJ cord-010119-t1x9gknd 9309 17 screening screening NN cord-010119-t1x9gknd 9309 18 test test NN cord-010119-t1x9gknd 9309 19 , , , cord-010119-t1x9gknd 9309 20 according accord VBG cord-010119-t1x9gknd 9309 21 to to IN cord-010119-t1x9gknd 9309 22 IND IND NNP cord-010119-t1x9gknd 9309 23 protocol protocol NN cord-010119-t1x9gknd 9309 24 . . . cord-010119-t1x9gknd 9310 1 No no DT cord-010119-t1x9gknd 9310 2 confirmatory confirmatory JJ cord-010119-t1x9gknd 9310 3 testing testing NN cord-010119-t1x9gknd 9310 4 was be VBD cord-010119-t1x9gknd 9310 5 performed perform VBN cord-010119-t1x9gknd 9310 6 per per IN cord-010119-t1x9gknd 9310 7 IND IND NNP cord-010119-t1x9gknd 9310 8 protocol protocol NN cord-010119-t1x9gknd 9310 9 or or CC cord-010119-t1x9gknd 9310 10 for for IN cord-010119-t1x9gknd 9310 11 donor donor NN cord-010119-t1x9gknd 9310 12 counseling counseling NN cord-010119-t1x9gknd 9310 13 , , , cord-010119-t1x9gknd 9310 14 so so CC cord-010119-t1x9gknd 9310 15 the the DT cord-010119-t1x9gknd 9310 16 true true JJ cord-010119-t1x9gknd 9310 17 positive positive JJ cord-010119-t1x9gknd 9310 18 rate rate NN cord-010119-t1x9gknd 9310 19 is be VBZ cord-010119-t1x9gknd 9310 20 unknown unknown JJ cord-010119-t1x9gknd 9310 21 . . . cord-010119-t1x9gknd 9311 1 In in IN cord-010119-t1x9gknd 9311 2 the the DT cord-010119-t1x9gknd 9311 3 prior prior JJ cord-010119-t1x9gknd 9311 4 IND IND NNP cord-010119-t1x9gknd 9311 5 trial trial NN cord-010119-t1x9gknd 9311 6 , , , cord-010119-t1x9gknd 9311 7 up up IN cord-010119-t1x9gknd 9311 8 to to TO cord-010119-t1x9gknd 9311 9 80 80 CD cord-010119-t1x9gknd 9311 10 % % NN cord-010119-t1x9gknd 9311 11 were be VBD cord-010119-t1x9gknd 9311 12 unlikely unlikely JJ cord-010119-t1x9gknd 9311 13 to to TO cord-010119-t1x9gknd 9311 14 transmit transmit VB cord-010119-t1x9gknd 9311 15 infection infection NN cord-010119-t1x9gknd 9311 16 in in IN cord-010119-t1x9gknd 9311 17 our -PRON- PRP$ cord-010119-t1x9gknd 9311 18 region region NN cord-010119-t1x9gknd 9311 19 , , , cord-010119-t1x9gknd 9311 20 i.e. i.e. FW cord-010119-t1x9gknd 9311 21 were be VBD cord-010119-t1x9gknd 9311 22 PCR PCR NNP cord-010119-t1x9gknd 9311 23 and and CC cord-010119-t1x9gknd 9311 24 blood blood NN cord-010119-t1x9gknd 9311 25 smear smear NN cord-010119-t1x9gknd 9311 26 negative negative JJ cord-010119-t1x9gknd 9311 27 . . . cord-010119-t1x9gknd 9312 1 Although although IN cord-010119-t1x9gknd 9312 2 a a DT cord-010119-t1x9gknd 9312 3 small small JJ cord-010119-t1x9gknd 9312 4 number number NN cord-010119-t1x9gknd 9312 5 of of IN cord-010119-t1x9gknd 9312 6 antibody antibody NN cord-010119-t1x9gknd 9312 7 positive positive JJ cord-010119-t1x9gknd 9312 8 , , , cord-010119-t1x9gknd 9312 9 PCR PCR NNP cord-010119-t1x9gknd 9312 10 negative negative JJ cord-010119-t1x9gknd 9312 11 donors donor NNS cord-010119-t1x9gknd 9312 12 may may MD cord-010119-t1x9gknd 9312 13 be be VB cord-010119-t1x9gknd 9312 14 actively actively RB cord-010119-t1x9gknd 9312 15 infected infect VBN cord-010119-t1x9gknd 9312 16 , , , cord-010119-t1x9gknd 9312 17 no no DT cord-010119-t1x9gknd 9312 18 transfusion transfusion NN cord-010119-t1x9gknd 9312 19 - - HYPH cord-010119-t1x9gknd 9312 20 transmitted transmit VBN cord-010119-t1x9gknd 9312 21 Babesia Babesia NNP cord-010119-t1x9gknd 9312 22 infections infection NNS cord-010119-t1x9gknd 9312 23 were be VBD cord-010119-t1x9gknd 9312 24 identified identify VBN cord-010119-t1x9gknd 9312 25 by by IN cord-010119-t1x9gknd 9312 26 lookback lookback JJ cord-010119-t1x9gknd 9312 27 investigations investigation NNS cord-010119-t1x9gknd 9312 28 . . . cord-010119-t1x9gknd 9313 1 Notification notification NN cord-010119-t1x9gknd 9313 2 of of IN cord-010119-t1x9gknd 9313 3 blood blood NN cord-010119-t1x9gknd 9313 4 donors donor NNS cord-010119-t1x9gknd 9313 5 with with IN cord-010119-t1x9gknd 9313 6 positive positive JJ cord-010119-t1x9gknd 9313 7 screening screening NN cord-010119-t1x9gknd 9313 8 results result NNS cord-010119-t1x9gknd 9313 9 was be VBD cord-010119-t1x9gknd 9313 10 also also RB cord-010119-t1x9gknd 9313 11 performed perform VBN cord-010119-t1x9gknd 9313 12 and and CC cord-010119-t1x9gknd 9313 13 information information NN cord-010119-t1x9gknd 9313 14 provided provide VBN cord-010119-t1x9gknd 9313 15 for for IN cord-010119-t1x9gknd 9313 16 healthcare healthcare NN cord-010119-t1x9gknd 9313 17 provider provider NN cord-010119-t1x9gknd 9313 18 followup followup NN cord-010119-t1x9gknd 9313 19 . . . cord-010119-t1x9gknd 9314 1 Overall overall RB cord-010119-t1x9gknd 9314 2 , , , cord-010119-t1x9gknd 9314 3 donor donor NN cord-010119-t1x9gknd 9314 4 deferral deferral NN cord-010119-t1x9gknd 9314 5 represented represent VBN cord-010119-t1x9gknd 9314 6 0.25 0.25 CD cord-010119-t1x9gknd 9314 7 % % NN cord-010119-t1x9gknd 9314 8 loss loss NN cord-010119-t1x9gknd 9314 9 of of IN cord-010119-t1x9gknd 9314 10 eligible eligible JJ cord-010119-t1x9gknd 9314 11 donors donor NNS cord-010119-t1x9gknd 9314 12 during during IN cord-010119-t1x9gknd 9314 13 this this DT cord-010119-t1x9gknd 9314 14 follow follow NN cord-010119-t1x9gknd 9314 15 - - HYPH cord-010119-t1x9gknd 9314 16 up up NN cord-010119-t1x9gknd 9314 17 period period NN cord-010119-t1x9gknd 9314 18 . . . cord-010119-t1x9gknd 9315 1 Deferred deferred JJ cord-010119-t1x9gknd 9315 2 donors donor NNS cord-010119-t1x9gknd 9315 3 were be VBD cord-010119-t1x9gknd 9315 4 invited invite VBN cord-010119-t1x9gknd 9315 5 to to TO cord-010119-t1x9gknd 9315 6 participate participate VB cord-010119-t1x9gknd 9315 7 in in IN cord-010119-t1x9gknd 9315 8 other other JJ cord-010119-t1x9gknd 9315 9 research research NN cord-010119-t1x9gknd 9315 10 collections collection NNS cord-010119-t1x9gknd 9315 11 not not RB cord-010119-t1x9gknd 9315 12 requiring require VBG cord-010119-t1x9gknd 9315 13 volunteer volunteer NN cord-010119-t1x9gknd 9315 14 donor donor NN cord-010119-t1x9gknd 9315 15 eligibility eligibility NN cord-010119-t1x9gknd 9315 16 . . . cord-010119-t1x9gknd 9316 1 Conclusion conclusion NN cord-010119-t1x9gknd 9316 2 : : : cord-010119-t1x9gknd 9316 3 Testing test VBG cord-010119-t1x9gknd 9316 4 for for IN cord-010119-t1x9gknd 9316 5 B b NN cord-010119-t1x9gknd 9316 6 microti microti NN cord-010119-t1x9gknd 9316 7 may may MD cord-010119-t1x9gknd 9316 8 help help VB cord-010119-t1x9gknd 9316 9 improve improve VB cord-010119-t1x9gknd 9316 10 blood blood NN cord-010119-t1x9gknd 9316 11 safety safety NN cord-010119-t1x9gknd 9316 12 , , , cord-010119-t1x9gknd 9316 13 particularly particularly RB cord-010119-t1x9gknd 9316 14 in in IN cord-010119-t1x9gknd 9316 15 endemic endemic JJ cord-010119-t1x9gknd 9316 16 regions region NNS cord-010119-t1x9gknd 9316 17 . . . cord-010119-t1x9gknd 9317 1 Although although IN cord-010119-t1x9gknd 9317 2 only only RB cord-010119-t1x9gknd 9317 3 0.25 0.25 CD cord-010119-t1x9gknd 9317 4 % % NN cord-010119-t1x9gknd 9317 5 of of IN cord-010119-t1x9gknd 9317 6 donors donor NNS cord-010119-t1x9gknd 9317 7 have have VBP cord-010119-t1x9gknd 9317 8 a a DT cord-010119-t1x9gknd 9317 9 positive positive JJ cord-010119-t1x9gknd 9317 10 reaction reaction NN cord-010119-t1x9gknd 9317 11 , , , cord-010119-t1x9gknd 9317 12 this this DT cord-010119-t1x9gknd 9317 13 represents represent VBZ cord-010119-t1x9gknd 9317 14 a a DT cord-010119-t1x9gknd 9317 15 significant significant JJ cord-010119-t1x9gknd 9317 16 loss loss NN cord-010119-t1x9gknd 9317 17 of of IN cord-010119-t1x9gknd 9317 18 eligible eligible JJ cord-010119-t1x9gknd 9317 19 donors donor NNS cord-010119-t1x9gknd 9317 20 over over IN cord-010119-t1x9gknd 9317 21 time time NN cord-010119-t1x9gknd 9317 22 , , , cord-010119-t1x9gknd 9317 23 most most JJS cord-010119-t1x9gknd 9317 24 of of IN cord-010119-t1x9gknd 9317 25 whom whom WP cord-010119-t1x9gknd 9317 26 are be VBP cord-010119-t1x9gknd 9317 27 unlikely unlikely JJ cord-010119-t1x9gknd 9317 28 to to TO cord-010119-t1x9gknd 9317 29 transmit transmit VB cord-010119-t1x9gknd 9317 30 infection infection NN cord-010119-t1x9gknd 9317 31 . . . cord-010119-t1x9gknd 9318 1 A a DT cord-010119-t1x9gknd 9318 2 direct direct JJ cord-010119-t1x9gknd 9318 3 test test NN cord-010119-t1x9gknd 9318 4 capable capable JJ cord-010119-t1x9gknd 9318 5 of of IN cord-010119-t1x9gknd 9318 6 detecting detect VBG cord-010119-t1x9gknd 9318 7 Babesia Babesia NNP cord-010119-t1x9gknd 9318 8 in in IN cord-010119-t1x9gknd 9318 9 individuals individual NNS cord-010119-t1x9gknd 9318 10 with with IN cord-010119-t1x9gknd 9318 11 very very RB cord-010119-t1x9gknd 9318 12 low low JJ cord-010119-t1x9gknd 9318 13 levels level NNS cord-010119-t1x9gknd 9318 14 of of IN cord-010119-t1x9gknd 9318 15 organisms organism NNS cord-010119-t1x9gknd 9318 16 without without IN cord-010119-t1x9gknd 9318 17 the the DT cord-010119-t1x9gknd 9318 18 need need NN cord-010119-t1x9gknd 9318 19 for for IN cord-010119-t1x9gknd 9318 20 concurrent concurrent JJ cord-010119-t1x9gknd 9318 21 antibody antibody NN cord-010119-t1x9gknd 9318 22 testing testing NN cord-010119-t1x9gknd 9318 23 would would MD cord-010119-t1x9gknd 9318 24 be be VB cord-010119-t1x9gknd 9318 25 ideal ideal JJ cord-010119-t1x9gknd 9318 26 . . . cord-010119-t1x9gknd 9319 1 A a DT cord-010119-t1x9gknd 9319 2 reinstatement reinstatement NN cord-010119-t1x9gknd 9319 3 protocol protocol NN cord-010119-t1x9gknd 9319 4 for for IN cord-010119-t1x9gknd 9319 5 donors donor NNS cord-010119-t1x9gknd 9319 6 who who WP cord-010119-t1x9gknd 9319 7 test test VBP cord-010119-t1x9gknd 9319 8 positive positive JJ cord-010119-t1x9gknd 9319 9 should should MD cord-010119-t1x9gknd 9319 10 also also RB cord-010119-t1x9gknd 9319 11 be be VB cord-010119-t1x9gknd 9319 12 considered consider VBN cord-010119-t1x9gknd 9319 13 . . . cord-010119-t1x9gknd 9320 1 Nonetheless nonetheless RB cord-010119-t1x9gknd 9320 2 , , , cord-010119-t1x9gknd 9320 3 the the DT cord-010119-t1x9gknd 9320 4 current current JJ cord-010119-t1x9gknd 9320 5 method method NN cord-010119-t1x9gknd 9320 6 of of IN cord-010119-t1x9gknd 9320 7 screening screening NN cord-010119-t1x9gknd 9320 8 is be VBZ cord-010119-t1x9gknd 9320 9 inexpensive inexpensive JJ cord-010119-t1x9gknd 9320 10 compared compare VBN cord-010119-t1x9gknd 9320 11 to to IN cord-010119-t1x9gknd 9320 12 PCR PCR NNP cord-010119-t1x9gknd 9320 13 - - HYPH cord-010119-t1x9gknd 9320 14 based base VBN cord-010119-t1x9gknd 9320 15 methods method NNS cord-010119-t1x9gknd 9320 16 . . . cord-010119-t1x9gknd 9321 1 Background Background NNP cord-010119-t1x9gknd 9321 2 / / SYM cord-010119-t1x9gknd 9321 3 Case Case NNP cord-010119-t1x9gknd 9321 4 Studies Studies NNPS cord-010119-t1x9gknd 9321 5 : : : cord-010119-t1x9gknd 9321 6 Human human JJ cord-010119-t1x9gknd 9321 7 anelloviruses anelloviruse NNS cord-010119-t1x9gknd 9321 8 are be VBP cord-010119-t1x9gknd 9321 9 the the DT cord-010119-t1x9gknd 9321 10 smallest small JJS cord-010119-t1x9gknd 9321 11 in in IN cord-010119-t1x9gknd 9321 12 particle particle NN cord-010119-t1x9gknd 9321 13 size size NN cord-010119-t1x9gknd 9321 14 , , , cord-010119-t1x9gknd 9321 15 smallest small JJS cord-010119-t1x9gknd 9321 16 in in IN cord-010119-t1x9gknd 9321 17 genome genome NN cord-010119-t1x9gknd 9321 18 size size NN cord-010119-t1x9gknd 9321 19 , , , cord-010119-t1x9gknd 9321 20 and and CC cord-010119-t1x9gknd 9321 21 least least RBS cord-010119-t1x9gknd 9321 22 complex complex JJ cord-010119-t1x9gknd 9321 23 in in IN cord-010119-t1x9gknd 9321 24 genetic genetic JJ cord-010119-t1x9gknd 9321 25 organization organization NN cord-010119-t1x9gknd 9321 26 of of IN cord-010119-t1x9gknd 9321 27 all all DT cord-010119-t1x9gknd 9321 28 human human JJ cord-010119-t1x9gknd 9321 29 pathogens pathogen NNS cord-010119-t1x9gknd 9321 30 . . . cord-010119-t1x9gknd 9322 1 They -PRON- PRP cord-010119-t1x9gknd 9322 2 establish establish VBP cord-010119-t1x9gknd 9322 3 a a DT cord-010119-t1x9gknd 9322 4 chronic chronic JJ cord-010119-t1x9gknd 9322 5 persistent persistent JJ cord-010119-t1x9gknd 9322 6 infection infection NN cord-010119-t1x9gknd 9322 7 in in IN cord-010119-t1x9gknd 9322 8 infancy infancy NN cord-010119-t1x9gknd 9322 9 or or CC cord-010119-t1x9gknd 9322 10 early early JJ cord-010119-t1x9gknd 9322 11 childhood childhood NN cord-010119-t1x9gknd 9322 12 and and CC cord-010119-t1x9gknd 9322 13 produce produce VB cord-010119-t1x9gknd 9322 14 a a DT cord-010119-t1x9gknd 9322 15 constantly constantly RB cord-010119-t1x9gknd 9322 16 detectable detectable JJ cord-010119-t1x9gknd 9322 17 load load NN cord-010119-t1x9gknd 9322 18 in in IN cord-010119-t1x9gknd 9322 19 plasma plasma NN cord-010119-t1x9gknd 9322 20 thereafter thereafter RB cord-010119-t1x9gknd 9322 21 . . . cord-010119-t1x9gknd 9323 1 Some some DT cord-010119-t1x9gknd 9323 2 studies study NNS cord-010119-t1x9gknd 9323 3 suggest suggest VBP cord-010119-t1x9gknd 9323 4 they -PRON- PRP cord-010119-t1x9gknd 9323 5 are be VBP cord-010119-t1x9gknd 9323 6 ubiquitous ubiquitous JJ cord-010119-t1x9gknd 9323 7 , , , cord-010119-t1x9gknd 9323 8 present present JJ cord-010119-t1x9gknd 9323 9 in in IN cord-010119-t1x9gknd 9323 10 > > $ cord-010119-t1x9gknd 9323 11 90 90 CD cord-010119-t1x9gknd 9323 12 % % NN cord-010119-t1x9gknd 9323 13 of of IN cord-010119-t1x9gknd 9323 14 the the DT cord-010119-t1x9gknd 9323 15 human human JJ cord-010119-t1x9gknd 9323 16 population population NN cord-010119-t1x9gknd 9323 17 , , , cord-010119-t1x9gknd 9323 18 and and CC cord-010119-t1x9gknd 9323 19 that that IN cord-010119-t1x9gknd 9323 20 immune immune JJ cord-010119-t1x9gknd 9323 21 surveillance surveillance NN cord-010119-t1x9gknd 9323 22 is be VBZ cord-010119-t1x9gknd 9323 23 required require VBN cord-010119-t1x9gknd 9323 24 to to TO cord-010119-t1x9gknd 9323 25 control control VB cord-010119-t1x9gknd 9323 26 the the DT cord-010119-t1x9gknd 9323 27 level level NN cord-010119-t1x9gknd 9323 28 of of IN cord-010119-t1x9gknd 9323 29 the the DT cord-010119-t1x9gknd 9323 30 virus virus NN cord-010119-t1x9gknd 9323 31 load load NN cord-010119-t1x9gknd 9323 32 . . . cord-010119-t1x9gknd 9324 1 Study Study NNP cord-010119-t1x9gknd 9324 2 Design Design NNP cord-010119-t1x9gknd 9324 3 / / SYM cord-010119-t1x9gknd 9324 4 Methods method NNS cord-010119-t1x9gknd 9324 5 : : : cord-010119-t1x9gknd 9324 6 We -PRON- PRP cord-010119-t1x9gknd 9324 7 have have VBP cord-010119-t1x9gknd 9324 8 developed develop VBN cord-010119-t1x9gknd 9324 9 a a DT cord-010119-t1x9gknd 9324 10 quantitative quantitative JJ cord-010119-t1x9gknd 9324 11 DNA dna NN cord-010119-t1x9gknd 9324 12 PCR pcr NN cord-010119-t1x9gknd 9324 13 assay assay NN cord-010119-t1x9gknd 9324 14 for for IN cord-010119-t1x9gknd 9324 15 the the DT cord-010119-t1x9gknd 9324 16 most most RBS cord-010119-t1x9gknd 9324 17 conserved conserve VBN cord-010119-t1x9gknd 9324 18 region region NN cord-010119-t1x9gknd 9324 19 of of IN cord-010119-t1x9gknd 9324 20 the the DT cord-010119-t1x9gknd 9324 21 Anellovirus Anellovirus NNP cord-010119-t1x9gknd 9324 22 genome genome NN cord-010119-t1x9gknd 9324 23 that that WDT cord-010119-t1x9gknd 9324 24 detects detect VBZ cord-010119-t1x9gknd 9324 25 all all DT cord-010119-t1x9gknd 9324 26 known know VBN cord-010119-t1x9gknd 9324 27 genotypes genotype NNS cord-010119-t1x9gknd 9324 28 of of IN cord-010119-t1x9gknd 9324 29 the the DT cord-010119-t1x9gknd 9324 30 virus virus NN cord-010119-t1x9gknd 9324 31 . . . cord-010119-t1x9gknd 9325 1 We -PRON- PRP cord-010119-t1x9gknd 9325 2 used use VBD cord-010119-t1x9gknd 9325 3 this this DT cord-010119-t1x9gknd 9325 4 assay assay NN cord-010119-t1x9gknd 9325 5 to to TO cord-010119-t1x9gknd 9325 6 examine examine VB cord-010119-t1x9gknd 9325 7 viral viral JJ cord-010119-t1x9gknd 9325 8 loads load NNS cord-010119-t1x9gknd 9325 9 in in IN cord-010119-t1x9gknd 9325 10 the the DT cord-010119-t1x9gknd 9325 11 plasma plasma NN cord-010119-t1x9gknd 9325 12 of of IN cord-010119-t1x9gknd 9325 13 US US NNP cord-010119-t1x9gknd 9325 14 blood blood NN cord-010119-t1x9gknd 9325 15 donors donor NNS cord-010119-t1x9gknd 9325 16 and and CC cord-010119-t1x9gknd 9325 17 transplant transplant NN cord-010119-t1x9gknd 9325 18 recipients recipient NNS cord-010119-t1x9gknd 9325 19 pre pre VBP cord-010119-t1x9gknd 9325 20 - - NN cord-010119-t1x9gknd 9325 21 transplant transplant NN cord-010119-t1x9gknd 9325 22 and and CC cord-010119-t1x9gknd 9325 23 three three CD cord-010119-t1x9gknd 9325 24 months month NNS cord-010119-t1x9gknd 9325 25 post post NN cord-010119-t1x9gknd 9325 26 - - NN cord-010119-t1x9gknd 9325 27 transplant transplant NN cord-010119-t1x9gknd 9325 28 . . . cord-010119-t1x9gknd 9326 1 Results result NNS cord-010119-t1x9gknd 9326 2 / / SYM cord-010119-t1x9gknd 9326 3 Findings finding NNS cord-010119-t1x9gknd 9326 4 : : : cord-010119-t1x9gknd 9327 1 For for IN cord-010119-t1x9gknd 9327 2 53 53 CD cord-010119-t1x9gknd 9327 3 blood blood NN cord-010119-t1x9gknd 9327 4 donors donor NNS cord-010119-t1x9gknd 9327 5 , , , cord-010119-t1x9gknd 9327 6 51 51 CD cord-010119-t1x9gknd 9327 7 were be VBD cord-010119-t1x9gknd 9327 8 positive positive JJ cord-010119-t1x9gknd 9327 9 with with IN cord-010119-t1x9gknd 9327 10 an an DT cord-010119-t1x9gknd 9327 11 average average JJ cord-010119-t1x9gknd 9327 12 load load NN cord-010119-t1x9gknd 9327 13 of of IN cord-010119-t1x9gknd 9327 14 1.49x10 1.49x10 CD cord-010119-t1x9gknd 9327 15 2 2 CD cord-010119-t1x9gknd 9327 16 copies copy NNS cord-010119-t1x9gknd 9327 17 / / SYM cord-010119-t1x9gknd 9327 18 mL ml NN cord-010119-t1x9gknd 9327 19 of of IN cord-010119-t1x9gknd 9327 20 plasma plasma NN cord-010119-t1x9gknd 9327 21 , , , cord-010119-t1x9gknd 9327 22 a a DT cord-010119-t1x9gknd 9327 23 median median JJ cord-010119-t1x9gknd 9327 24 value value NN cord-010119-t1x9gknd 9327 25 of of IN cord-010119-t1x9gknd 9327 26 80.5 80.5 CD cord-010119-t1x9gknd 9327 27 copies copy NNS cord-010119-t1x9gknd 9327 28 / / SYM cord-010119-t1x9gknd 9327 29 mL ml NN cord-010119-t1x9gknd 9327 30 of of IN cord-010119-t1x9gknd 9327 31 plasma plasma NN cord-010119-t1x9gknd 9327 32 , , , cord-010119-t1x9gknd 9327 33 ranging range VBG cord-010119-t1x9gknd 9327 34 from from IN cord-010119-t1x9gknd 9327 35 0 0 CD cord-010119-t1x9gknd 9327 36 to to IN cord-010119-t1x9gknd 9327 37 1.87x10 1.87x10 CD cord-010119-t1x9gknd 9327 38 3 3 CD cord-010119-t1x9gknd 9327 39 copies copy NNS cord-010119-t1x9gknd 9327 40 / / SYM cord-010119-t1x9gknd 9327 41 mL. mL. NNS cord-010119-t1x9gknd 9327 42 Pre pre JJ cord-010119-t1x9gknd 9327 43 - - JJ cord-010119-t1x9gknd 9327 44 transplant transplant NN cord-010119-t1x9gknd 9327 45 viral viral JJ cord-010119-t1x9gknd 9327 46 loads load NNS cord-010119-t1x9gknd 9327 47 were be VBD cord-010119-t1x9gknd 9327 48 similar similar JJ cord-010119-t1x9gknd 9327 49 . . . cord-010119-t1x9gknd 9328 1 For for IN cord-010119-t1x9gknd 9328 2 41 41 CD cord-010119-t1x9gknd 9328 3 transplant transplant NN cord-010119-t1x9gknd 9328 4 candidates candidate NNS cord-010119-t1x9gknd 9328 5 , , , cord-010119-t1x9gknd 9328 6 40 40 CD cord-010119-t1x9gknd 9328 7 were be VBD cord-010119-t1x9gknd 9328 8 positive positive JJ cord-010119-t1x9gknd 9328 9 with with IN cord-010119-t1x9gknd 9328 10 an an DT cord-010119-t1x9gknd 9328 11 average average NN cord-010119-t1x9gknd 9328 12 of of IN cord-010119-t1x9gknd 9328 13 3.70x10 3.70x10 CD cord-010119-t1x9gknd 9328 14 2 2 CD cord-010119-t1x9gknd 9328 15 copies copy NNS cord-010119-t1x9gknd 9328 16 / / SYM cord-010119-t1x9gknd 9328 17 mL ml NN cord-010119-t1x9gknd 9328 18 of of IN cord-010119-t1x9gknd 9328 19 plasma plasma NN cord-010119-t1x9gknd 9328 20 , , , cord-010119-t1x9gknd 9328 21 a a DT cord-010119-t1x9gknd 9328 22 median median JJ cord-010119-t1x9gknd 9328 23 value value NN cord-010119-t1x9gknd 9328 24 of of IN cord-010119-t1x9gknd 9328 25 88 88 CD cord-010119-t1x9gknd 9328 26 copies copy NNS cord-010119-t1x9gknd 9328 27 / / SYM cord-010119-t1x9gknd 9328 28 mL ml NN cord-010119-t1x9gknd 9328 29 of of IN cord-010119-t1x9gknd 9328 30 plasma plasma NN cord-010119-t1x9gknd 9328 31 , , , cord-010119-t1x9gknd 9328 32 ranging range VBG cord-010119-t1x9gknd 9328 33 from from IN cord-010119-t1x9gknd 9328 34 0 0 CD cord-010119-t1x9gknd 9328 35 to to IN cord-010119-t1x9gknd 9328 36 1.18x10 1.18x10 CD cord-010119-t1x9gknd 9328 37 5 5 CD cord-010119-t1x9gknd 9328 38 copies copy NNS cord-010119-t1x9gknd 9328 39 / / SYM cord-010119-t1x9gknd 9328 40 mL. mL. NNP cord-010119-t1x9gknd 9328 41 Post post NN cord-010119-t1x9gknd 9328 42 - - JJ cord-010119-t1x9gknd 9328 43 transplant transplant NN cord-010119-t1x9gknd 9328 44 viral viral JJ cord-010119-t1x9gknd 9328 45 loads load NNS cord-010119-t1x9gknd 9328 46 were be VBD cord-010119-t1x9gknd 9328 47 remarkably remarkably RB cord-010119-t1x9gknd 9328 48 different different JJ cord-010119-t1x9gknd 9328 49 . . . cord-010119-t1x9gknd 9329 1 For for IN cord-010119-t1x9gknd 9329 2 94 94 CD cord-010119-t1x9gknd 9329 3 transplant transplant NN cord-010119-t1x9gknd 9329 4 recipients recipient NNS cord-010119-t1x9gknd 9329 5 , , , cord-010119-t1x9gknd 9329 6 all all DT cord-010119-t1x9gknd 9329 7 were be VBD cord-010119-t1x9gknd 9329 8 positive positive JJ cord-010119-t1x9gknd 9329 9 with with IN cord-010119-t1x9gknd 9329 10 an an DT cord-010119-t1x9gknd 9329 11 average average NN cord-010119-t1x9gknd 9329 12 of of IN cord-010119-t1x9gknd 9330 1 3.14x10 3.14x10 CD cord-010119-t1x9gknd 9330 2 5 5 CD cord-010119-t1x9gknd 9330 3 copies copy NNS cord-010119-t1x9gknd 9330 4 / / SYM cord-010119-t1x9gknd 9330 5 mL ml NN cord-010119-t1x9gknd 9330 6 of of IN cord-010119-t1x9gknd 9330 7 plasma plasma NN cord-010119-t1x9gknd 9330 8 , , , cord-010119-t1x9gknd 9330 9 a a DT cord-010119-t1x9gknd 9330 10 median median JJ cord-010119-t1x9gknd 9330 11 value value NN cord-010119-t1x9gknd 9330 12 of of IN cord-010119-t1x9gknd 9330 13 1.25x10 1.25x10 CD cord-010119-t1x9gknd 9330 14 5 5 CD cord-010119-t1x9gknd 9330 15 copies copy NNS cord-010119-t1x9gknd 9330 16 / / SYM cord-010119-t1x9gknd 9330 17 mL ml NN cord-010119-t1x9gknd 9330 18 of of IN cord-010119-t1x9gknd 9330 19 plasma plasma NN cord-010119-t1x9gknd 9330 20 , , , cord-010119-t1x9gknd 9330 21 ranging range VBG cord-010119-t1x9gknd 9330 22 from from IN cord-010119-t1x9gknd 9330 23 0 0 CD cord-010119-t1x9gknd 9330 24 to to IN cord-010119-t1x9gknd 9330 25 4.6x10 4.6x10 CD cord-010119-t1x9gknd 9330 26 7 7 CD cord-010119-t1x9gknd 9330 27 copies copy NNS cord-010119-t1x9gknd 9330 28 / / SYM cord-010119-t1x9gknd 9330 29 mL. mL. NNS cord-010119-t1x9gknd 9330 30 Conclusion conclusion NN cord-010119-t1x9gknd 9330 31 : : : cord-010119-t1x9gknd 9330 32 These these DT cord-010119-t1x9gknd 9330 33 results result NNS cord-010119-t1x9gknd 9330 34 validate validate VBP cord-010119-t1x9gknd 9330 35 the the DT cord-010119-t1x9gknd 9330 36 PCR PCR NNP cord-010119-t1x9gknd 9330 37 assay assay NN cord-010119-t1x9gknd 9330 38 that that WDT cord-010119-t1x9gknd 9330 39 was be VBD cord-010119-t1x9gknd 9330 40 developed develop VBN cord-010119-t1x9gknd 9330 41 and and CC cord-010119-t1x9gknd 9330 42 confirm confirm VB cord-010119-t1x9gknd 9330 43 that that IN cord-010119-t1x9gknd 9330 44 detectable detectable JJ cord-010119-t1x9gknd 9330 45 viral viral JJ cord-010119-t1x9gknd 9330 46 loads load NNS cord-010119-t1x9gknd 9330 47 of of IN cord-010119-t1x9gknd 9330 48 around around RB cord-010119-t1x9gknd 9330 49 100 100 CD cord-010119-t1x9gknd 9330 50 - - HYPH cord-010119-t1x9gknd 9330 51 200 200 CD cord-010119-t1x9gknd 9330 52 copies copy NNS cord-010119-t1x9gknd 9330 53 were be VBD cord-010119-t1x9gknd 9330 54 present present JJ cord-010119-t1x9gknd 9330 55 in in IN cord-010119-t1x9gknd 9330 56 > > $ cord-010119-t1x9gknd 9330 57 90 90 CD cord-010119-t1x9gknd 9330 58 % % NN cord-010119-t1x9gknd 9330 59 of of IN cord-010119-t1x9gknd 9330 60 the the DT cord-010119-t1x9gknd 9330 61 blood blood NN cord-010119-t1x9gknd 9330 62 donors donor NNS cord-010119-t1x9gknd 9330 63 surveyed survey VBD cord-010119-t1x9gknd 9330 64 . . . cord-010119-t1x9gknd 9331 1 In in IN cord-010119-t1x9gknd 9331 2 addition addition NN cord-010119-t1x9gknd 9331 3 , , , cord-010119-t1x9gknd 9331 4 the the DT cord-010119-t1x9gknd 9331 5 effect effect NN cord-010119-t1x9gknd 9331 6 of of IN cord-010119-t1x9gknd 9331 7 post post JJ cord-010119-t1x9gknd 9331 8 - - JJ cord-010119-t1x9gknd 9331 9 transplant transplant JJ cord-010119-t1x9gknd 9331 10 immunosuppressive immunosuppressive JJ cord-010119-t1x9gknd 9331 11 therapy therapy NN cord-010119-t1x9gknd 9331 12 has have VBZ cord-010119-t1x9gknd 9331 13 caused cause VBN cord-010119-t1x9gknd 9331 14 an an DT cord-010119-t1x9gknd 9331 15 increase increase NN cord-010119-t1x9gknd 9331 16 in in IN cord-010119-t1x9gknd 9331 17 the the DT cord-010119-t1x9gknd 9331 18 viral viral JJ cord-010119-t1x9gknd 9331 19 load load NN cord-010119-t1x9gknd 9331 20 of of IN cord-010119-t1x9gknd 9331 21 at at RB cord-010119-t1x9gknd 9331 22 least least JJS cord-010119-t1x9gknd 9331 23 2 2 CD cord-010119-t1x9gknd 9331 24 orders order NNS cord-010119-t1x9gknd 9331 25 of of IN cord-010119-t1x9gknd 9331 26 magnitude magnitude NN cord-010119-t1x9gknd 9331 27 above above IN cord-010119-t1x9gknd 9331 28 that that DT cord-010119-t1x9gknd 9331 29 of of IN cord-010119-t1x9gknd 9331 30 non non JJ cord-010119-t1x9gknd 9331 31 - - JJ cord-010119-t1x9gknd 9331 32 immunosuppressed immunosuppressed JJ cord-010119-t1x9gknd 9331 33 individuals individual NNS cord-010119-t1x9gknd 9331 34 . . . cord-010119-t1x9gknd 9332 1 Background Background NNP cord-010119-t1x9gknd 9332 2 / / SYM cord-010119-t1x9gknd 9332 3 Case Case NNP cord-010119-t1x9gknd 9332 4 Studies Studies NNPS cord-010119-t1x9gknd 9332 5 : : : cord-010119-t1x9gknd 9333 1 The the DT cord-010119-t1x9gknd 9333 2 screening screening NN cord-010119-t1x9gknd 9333 3 of of IN cord-010119-t1x9gknd 9333 4 blood blood NN cord-010119-t1x9gknd 9333 5 donors donor NNS cord-010119-t1x9gknd 9333 6 and and CC cord-010119-t1x9gknd 9333 7 travelers traveler NNS cord-010119-t1x9gknd 9333 8 returning return VBG cord-010119-t1x9gknd 9333 9 from from IN cord-010119-t1x9gknd 9333 10 endemic endemic JJ cord-010119-t1x9gknd 9333 11 / / SYM cord-010119-t1x9gknd 9333 12 epidemic epidemic NN cord-010119-t1x9gknd 9333 13 areas area NNS cord-010119-t1x9gknd 9333 14 has have VBZ cord-010119-t1x9gknd 9333 15 highlighted highlight VBN cord-010119-t1x9gknd 9333 16 the the DT cord-010119-t1x9gknd 9333 17 importance importance NN cord-010119-t1x9gknd 9333 18 of of IN cord-010119-t1x9gknd 9333 19 multiplex multiplex JJ cord-010119-t1x9gknd 9333 20 diagnostic diagnostic JJ cord-010119-t1x9gknd 9333 21 approaches approach NNS cord-010119-t1x9gknd 9333 22 for for IN cord-010119-t1x9gknd 9333 23 the the DT cord-010119-t1x9gknd 9333 24 simultaneous simultaneous JJ cord-010119-t1x9gknd 9333 25 analysis analysis NN cord-010119-t1x9gknd 9333 26 of of IN cord-010119-t1x9gknd 9333 27 various various JJ cord-010119-t1x9gknd 9333 28 pathogens pathogen NNS cord-010119-t1x9gknd 9333 29 . . . cord-010119-t1x9gknd 9334 1 Furthermore furthermore RB cord-010119-t1x9gknd 9334 2 , , , cord-010119-t1x9gknd 9334 3 in in IN cord-010119-t1x9gknd 9334 4 the the DT cord-010119-t1x9gknd 9334 5 context context NN cord-010119-t1x9gknd 9334 6 of of IN cord-010119-t1x9gknd 9334 7 similar similar JJ cord-010119-t1x9gknd 9334 8 clinical clinical JJ cord-010119-t1x9gknd 9334 9 signs sign NNS cord-010119-t1x9gknd 9334 10 , , , cord-010119-t1x9gknd 9334 11 the the DT cord-010119-t1x9gknd 9334 12 differential differential JJ cord-010119-t1x9gknd 9334 13 diagnosis diagnosis NN cord-010119-t1x9gknd 9334 14 of of IN cord-010119-t1x9gknd 9334 15 arboviruses arbovirus NNS cord-010119-t1x9gknd 9334 16 during during IN cord-010119-t1x9gknd 9334 17 acute acute JJ cord-010119-t1x9gknd 9334 18 infection infection NN cord-010119-t1x9gknd 9334 19 is be VBZ cord-010119-t1x9gknd 9334 20 essential essential JJ cord-010119-t1x9gknd 9334 21 to to TO cord-010119-t1x9gknd 9334 22 discriminate discriminate VB cord-010119-t1x9gknd 9334 23 the the DT cord-010119-t1x9gknd 9334 24 causative causative JJ cord-010119-t1x9gknd 9334 25 agent agent NN cord-010119-t1x9gknd 9334 26 for for IN cord-010119-t1x9gknd 9334 27 patient patient JJ cord-010119-t1x9gknd 9334 28 management management NN cord-010119-t1x9gknd 9334 29 and and CC cord-010119-t1x9gknd 9334 30 epidemiological epidemiological JJ cord-010119-t1x9gknd 9334 31 surveillance surveillance NN cord-010119-t1x9gknd 9334 32 . . . cord-010119-t1x9gknd 9335 1 The the DT cord-010119-t1x9gknd 9335 2 development development NN cord-010119-t1x9gknd 9335 3 of of IN cord-010119-t1x9gknd 9335 4 a a DT cord-010119-t1x9gknd 9335 5 flexible flexible JJ cord-010119-t1x9gknd 9335 6 diagnostic diagnostic JJ cord-010119-t1x9gknd 9335 7 approach approach NN cord-010119-t1x9gknd 9335 8 is be VBZ cord-010119-t1x9gknd 9335 9 a a DT cord-010119-t1x9gknd 9335 10 key key JJ cord-010119-t1x9gknd 9335 11 challenge challenge NN cord-010119-t1x9gknd 9335 12 to to TO cord-010119-t1x9gknd 9335 13 face face VB cord-010119-t1x9gknd 9335 14 the the DT cord-010119-t1x9gknd 9335 15 continuing continue VBG cord-010119-t1x9gknd 9335 16 emergence emergence NN cord-010119-t1x9gknd 9335 17 of of IN cord-010119-t1x9gknd 9335 18 arboviruses arbovirus NNS cord-010119-t1x9gknd 9335 19 , , , cord-010119-t1x9gknd 9335 20 belonging belong VBG cord-010119-t1x9gknd 9335 21 to to IN cord-010119-t1x9gknd 9335 22 flavivirus flavivirus NNP cord-010119-t1x9gknd 9335 23 and and CC cord-010119-t1x9gknd 9335 24 alphavirus alphavirus NNP cord-010119-t1x9gknd 9335 25 , , , cord-010119-t1x9gknd 9335 26 such such JJ cord-010119-t1x9gknd 9335 27 as as IN cord-010119-t1x9gknd 9335 28 Dengue Dengue NNP cord-010119-t1x9gknd 9335 29 virus virus NN cord-010119-t1x9gknd 9335 30 ( ( -LRB- cord-010119-t1x9gknd 9335 31 DENV DENV NNP cord-010119-t1x9gknd 9335 32 ) ) -RRB- cord-010119-t1x9gknd 9335 33 , , , cord-010119-t1x9gknd 9335 34 West West NNP cord-010119-t1x9gknd 9335 35 Nile Nile NNP cord-010119-t1x9gknd 9335 36 virus virus NN cord-010119-t1x9gknd 9335 37 ( ( -LRB- cord-010119-t1x9gknd 9335 38 WNV WNV NNP cord-010119-t1x9gknd 9335 39 ) ) -RRB- cord-010119-t1x9gknd 9335 40 , , , cord-010119-t1x9gknd 9335 41 Zika Zika NNP cord-010119-t1x9gknd 9335 42 virus virus NN cord-010119-t1x9gknd 9335 43 ( ( -LRB- cord-010119-t1x9gknd 9335 44 ZIKV ZIKV NNP cord-010119-t1x9gknd 9335 45 ) ) -RRB- cord-010119-t1x9gknd 9335 46 , , , cord-010119-t1x9gknd 9335 47 Yellow Yellow NNP cord-010119-t1x9gknd 9335 48 Fever Fever NNP cord-010119-t1x9gknd 9335 49 virus virus NN cord-010119-t1x9gknd 9335 50 ( ( -LRB- cord-010119-t1x9gknd 9335 51 YFV YFV NNP cord-010119-t1x9gknd 9335 52 ) ) -RRB- cord-010119-t1x9gknd 9335 53 , , , cord-010119-t1x9gknd 9335 54 Usutu Usutu NNP cord-010119-t1x9gknd 9335 55 virus virus NN cord-010119-t1x9gknd 9335 56 ( ( -LRB- cord-010119-t1x9gknd 9335 57 USUV USUV NNP cord-010119-t1x9gknd 9335 58 ) ) -RRB- cord-010119-t1x9gknd 9335 59 and and CC cord-010119-t1x9gknd 9335 60 Chikungunya Chikungunya NNP cord-010119-t1x9gknd 9335 61 virus virus NN cord-010119-t1x9gknd 9335 62 ( ( -LRB- cord-010119-t1x9gknd 9335 63 CHIKV CHIKV NNP cord-010119-t1x9gknd 9335 64 ) ) -RRB- cord-010119-t1x9gknd 9335 65 . . . cord-010119-t1x9gknd 9336 1 Study Study NNP cord-010119-t1x9gknd 9336 2 Design Design NNP cord-010119-t1x9gknd 9336 3 / / SYM cord-010119-t1x9gknd 9336 4 Method method NN cord-010119-t1x9gknd 9336 5 : : : cord-010119-t1x9gknd 9337 1 An an DT cord-010119-t1x9gknd 9337 2 innovative innovative JJ cord-010119-t1x9gknd 9337 3 diagnostic diagnostic JJ cord-010119-t1x9gknd 9337 4 approach approach NN cord-010119-t1x9gknd 9337 5 combining combine VBG cord-010119-t1x9gknd 9337 6 generic generic JJ cord-010119-t1x9gknd 9337 7 RT RT NNP cord-010119-t1x9gknd 9337 8 - - HYPH cord-010119-t1x9gknd 9337 9 PCR pcr NN cord-010119-t1x9gknd 9337 10 amplification amplification NN cord-010119-t1x9gknd 9337 11 and and CC cord-010119-t1x9gknd 9337 12 identification identification NN cord-010119-t1x9gknd 9337 13 on on IN cord-010119-t1x9gknd 9337 14 low low JJ cord-010119-t1x9gknd 9337 15 cost cost NN cord-010119-t1x9gknd 9337 16 microarrays microarray NNS cord-010119-t1x9gknd 9337 17 has have VBZ cord-010119-t1x9gknd 9337 18 been be VBN cord-010119-t1x9gknd 9337 19 developed develop VBN cord-010119-t1x9gknd 9337 20 . . . cord-010119-t1x9gknd 9338 1 We -PRON- PRP cord-010119-t1x9gknd 9338 2 have have VBP cord-010119-t1x9gknd 9338 3 patented patent VBN cord-010119-t1x9gknd 9338 4 original original JJ cord-010119-t1x9gknd 9338 5 polythiolated polythiolated JJ cord-010119-t1x9gknd 9338 6 probes probe NNS cord-010119-t1x9gknd 9338 7 grafted graft VBN cord-010119-t1x9gknd 9338 8 on on IN cord-010119-t1x9gknd 9338 9 maleimide maleimide NN cord-010119-t1x9gknd 9338 10 - - HYPH cord-010119-t1x9gknd 9338 11 activated activate VBN cord-010119-t1x9gknd 9338 12 microplates microplate NNS cord-010119-t1x9gknd 9338 13 for for IN cord-010119-t1x9gknd 9338 14 the the DT cord-010119-t1x9gknd 9338 15 robust robust JJ cord-010119-t1x9gknd 9338 16 , , , cord-010119-t1x9gknd 9338 17 sensitive sensitive JJ cord-010119-t1x9gknd 9338 18 and and CC cord-010119-t1x9gknd 9338 19 specific specific JJ cord-010119-t1x9gknd 9338 20 Mean Mean NNP cord-010119-t1x9gknd 9338 21 CCI CCI NNP cord-010119-t1x9gknd 9338 22 Pre Pre NNP cord-010119-t1x9gknd 9338 23 - - NNP cord-010119-t1x9gknd 9338 24 IVIG IVIG NNP cord-010119-t1x9gknd 9338 25 : : : cord-010119-t1x9gknd 9339 1 All all DT cord-010119-t1x9gknd 9339 2 PLT PLT NNP cord-010119-t1x9gknd 9339 3 ( ( -LRB- cord-010119-t1x9gknd 9339 4 17 17 CD cord-010119-t1x9gknd 9339 5 ) ) -RRB- cord-010119-t1x9gknd 9339 6 0.2 0.2 CD cord-010119-t1x9gknd 9339 7 Post Post NNP cord-010119-t1x9gknd 9339 8 - - NN cord-010119-t1x9gknd 9339 9 IVIG IVIG NNP cord-010119-t1x9gknd 9339 10 : : : cord-010119-t1x9gknd 9340 1 All all DT cord-010119-t1x9gknd 9340 2 PLT PLT NNP cord-010119-t1x9gknd 9340 3 ( ( -LRB- cord-010119-t1x9gknd 9340 4 41 41 CD cord-010119-t1x9gknd 9340 5 ) ) -RRB- cord-010119-t1x9gknd 9341 1 5.5 5.5 CD cord-010119-t1x9gknd 9341 2 Post Post NNP cord-010119-t1x9gknd 9341 3 - - NN cord-010119-t1x9gknd 9341 4 IVIG IVIG NNP cord-010119-t1x9gknd 9341 5 : : : cord-010119-t1x9gknd 9342 1 CD36-negative cd36-negative CD cord-010119-t1x9gknd 9342 2 PLT PLT NNP cord-010119-t1x9gknd 9342 3 from from IN cord-010119-t1x9gknd 9342 4 relative relative JJ cord-010119-t1x9gknd 9342 5 ( ( -LRB- cord-010119-t1x9gknd 9342 6 1 1 CD cord-010119-t1x9gknd 9342 7 ) ) -RRB- cord-010119-t1x9gknd 9342 8 0.8 0.8 CD cord-010119-t1x9gknd 9342 9 Post Post NNP cord-010119-t1x9gknd 9342 10 - - NN cord-010119-t1x9gknd 9342 11 IVIG IVIG NNP cord-010119-t1x9gknd 9342 12 : : : cord-010119-t1x9gknd 9343 1 Single Single NNP cord-010119-t1x9gknd 9343 2 Donor Donor NNP cord-010119-t1x9gknd 9343 3 Apheresis Apheresis NNP cord-010119-t1x9gknd 9343 4 ( ( -LRB- cord-010119-t1x9gknd 9343 5 23 23 CD cord-010119-t1x9gknd 9343 6 ) ) -RRB- cord-010119-t1x9gknd 9343 7 4.3 4.3 CD cord-010119-t1x9gknd 9343 8 Post Post NNP cord-010119-t1x9gknd 9343 9 - - NN cord-010119-t1x9gknd 9343 10 IVIG IVIG NNP cord-010119-t1x9gknd 9343 11 : : : cord-010119-t1x9gknd 9343 12 Cross cross NN cord-010119-t1x9gknd 9343 13 - - NN cord-010119-t1x9gknd 9343 14 match match NN cord-010119-t1x9gknd 9343 15 Compatible Compatible NNP cord-010119-t1x9gknd 9343 16 ( ( -LRB- cord-010119-t1x9gknd 9343 17 15 15 CD cord-010119-t1x9gknd 9343 18 ) ) -RRB- cord-010119-t1x9gknd 9343 19 6.1 6.1 CD cord-010119-t1x9gknd 9343 20 Post Post NNP cord-010119-t1x9gknd 9343 21 - - NN cord-010119-t1x9gknd 9343 22 IVIG IVIG NNP cord-010119-t1x9gknd 9343 23 : : : cord-010119-t1x9gknd 9344 1 Flow flow VB cord-010119-t1x9gknd 9344 2 Cross Cross NNP cord-010119-t1x9gknd 9344 3 - - NN cord-010119-t1x9gknd 9344 4 match match NN cord-010119-t1x9gknd 9344 5 Compatible compatible JJ cord-010119-t1x9gknd 9344 6 PLT PLT NNP cord-010119-t1x9gknd 9344 7 ( ( -LRB- cord-010119-t1x9gknd 9344 8 2 2 CD cord-010119-t1x9gknd 9344 9 ) ) -RRB- cord-010119-t1x9gknd 9344 10 12.6 12.6 CD cord-010119-t1x9gknd 9344 11 188A 188a CD cord-010119-t1x9gknd 9344 12 TRANSFUSION transfusion NN cord-010119-t1x9gknd 9344 13 2017 2017 CD cord-010119-t1x9gknd 9344 14 Vol Vol NNP cord-010119-t1x9gknd 9344 15 . . . cord-010119-t1x9gknd 9345 1 57 57 CD cord-010119-t1x9gknd 9345 2 Supplement supplement NN cord-010119-t1x9gknd 9345 3 S3 S3 NNP cord-010119-t1x9gknd 9345 4 detection detection NN cord-010119-t1x9gknd 9345 5 of of IN cord-010119-t1x9gknd 9345 6 the the DT cord-010119-t1x9gknd 9345 7 viral viral JJ cord-010119-t1x9gknd 9345 8 genomes genome NNS cord-010119-t1x9gknd 9345 9 . . . cord-010119-t1x9gknd 9346 1 Analytical analytical JJ cord-010119-t1x9gknd 9346 2 performances performance NNS cord-010119-t1x9gknd 9346 3 of of IN cord-010119-t1x9gknd 9346 4 the the DT cord-010119-t1x9gknd 9346 5 test test NN cord-010119-t1x9gknd 9346 6 were be VBD cord-010119-t1x9gknd 9346 7 evaluated evaluate VBN cord-010119-t1x9gknd 9346 8 on on IN cord-010119-t1x9gknd 9346 9 viral viral JJ cord-010119-t1x9gknd 9346 10 standards standard NNS cord-010119-t1x9gknd 9346 11 and and CC cord-010119-t1x9gknd 9346 12 on on IN cord-010119-t1x9gknd 9346 13 clinical clinical JJ cord-010119-t1x9gknd 9346 14 samples sample NNS cord-010119-t1x9gknd 9346 15 : : : cord-010119-t1x9gknd 9346 16 DENV DENV NNP cord-010119-t1x9gknd 9346 17 ( ( -LRB- cord-010119-t1x9gknd 9346 18 1/2/3/4 1/2/3/4 CD cord-010119-t1x9gknd 9346 19 ) ) -RRB- cord-010119-t1x9gknd 9346 20 , , , cord-010119-t1x9gknd 9346 21 WNV WNV NNP cord-010119-t1x9gknd 9346 22 , , , cord-010119-t1x9gknd 9346 23 ZIKV ZIKV NNP cord-010119-t1x9gknd 9346 24 and and CC cord-010119-t1x9gknd 9346 25 CHIKV CHIKV NNP cord-010119-t1x9gknd 9346 26 . . . cord-010119-t1x9gknd 9347 1 Forty forty CD cord-010119-t1x9gknd 9347 2 human human JJ cord-010119-t1x9gknd 9347 3 plasmas plasma NNS cord-010119-t1x9gknd 9347 4 from from IN cord-010119-t1x9gknd 9347 5 blood blood NN cord-010119-t1x9gknd 9347 6 donors donor NNS cord-010119-t1x9gknd 9347 7 with with IN cord-010119-t1x9gknd 9347 8 no no DT cord-010119-t1x9gknd 9347 9 history history NN cord-010119-t1x9gknd 9347 10 of of IN cord-010119-t1x9gknd 9347 11 contact contact NN cord-010119-t1x9gknd 9347 12 with with IN cord-010119-t1x9gknd 9347 13 arboviruses arbovirus NNS cord-010119-t1x9gknd 9347 14 were be VBD cord-010119-t1x9gknd 9347 15 used use VBN cord-010119-t1x9gknd 9347 16 as as IN cord-010119-t1x9gknd 9347 17 negative negative JJ cord-010119-t1x9gknd 9347 18 controls control NNS cord-010119-t1x9gknd 9347 19 . . . cord-010119-t1x9gknd 9348 1 We -PRON- PRP cord-010119-t1x9gknd 9348 2 have have VBP cord-010119-t1x9gknd 9348 3 designed design VBN cord-010119-t1x9gknd 9348 4 two two CD cord-010119-t1x9gknd 9348 5 sets set NNS cord-010119-t1x9gknd 9348 6 of of IN cord-010119-t1x9gknd 9348 7 degenerated degenerate VBN cord-010119-t1x9gknd 9348 8 primers primer NNS cord-010119-t1x9gknd 9348 9 for for IN cord-010119-t1x9gknd 9348 10 the the DT cord-010119-t1x9gknd 9348 11 generic generic JJ cord-010119-t1x9gknd 9348 12 RT RT NNP cord-010119-t1x9gknd 9348 13 - - HYPH cord-010119-t1x9gknd 9348 14 PCR PCR NNP cord-010119-t1x9gknd 9348 15 amplification amplification NN cord-010119-t1x9gknd 9348 16 of of IN cord-010119-t1x9gknd 9348 17 all all DT cord-010119-t1x9gknd 9348 18 flaviviruses flavivirus NNS cord-010119-t1x9gknd 9348 19 and and CC cord-010119-t1x9gknd 9348 20 for for IN cord-010119-t1x9gknd 9348 21 CHIKV CHIKV NNP cord-010119-t1x9gknd 9348 22 . . . cord-010119-t1x9gknd 9349 1 Biotinylated Biotinylated NNP cord-010119-t1x9gknd 9349 2 amplicons amplicon NNS cord-010119-t1x9gknd 9349 3 were be VBD cord-010119-t1x9gknd 9349 4 captured capture VBN cord-010119-t1x9gknd 9349 5 on on IN cord-010119-t1x9gknd 9349 6 complementary complementary JJ cord-010119-t1x9gknd 9349 7 grafted graft VBN cord-010119-t1x9gknd 9349 8 polythiolated polythiolate VBN cord-010119-t1x9gknd 9349 9 probes probe NNS cord-010119-t1x9gknd 9349 10 on on IN cord-010119-t1x9gknd 9349 11 microplate microplate NN cord-010119-t1x9gknd 9349 12 . . . cord-010119-t1x9gknd 9350 1 After after IN cord-010119-t1x9gknd 9350 2 addition addition NN cord-010119-t1x9gknd 9350 3 of of IN cord-010119-t1x9gknd 9350 4 streptavidin streptavidin NN cord-010119-t1x9gknd 9350 5 - - HYPH cord-010119-t1x9gknd 9350 6 europium europium NN cord-010119-t1x9gknd 9350 7 label label NN cord-010119-t1x9gknd 9350 8 , , , cord-010119-t1x9gknd 9350 9 the the DT cord-010119-t1x9gknd 9350 10 molecular molecular JJ cord-010119-t1x9gknd 9350 11 hybridization hybridization NN cord-010119-t1x9gknd 9350 12 events event NNS cord-010119-t1x9gknd 9350 13 were be VBD cord-010119-t1x9gknd 9350 14 detected detect VBN cord-010119-t1x9gknd 9350 15 by by IN cord-010119-t1x9gknd 9350 16 time time NN cord-010119-t1x9gknd 9350 17 - - HYPH cord-010119-t1x9gknd 9350 18 resolved resolve VBN cord-010119-t1x9gknd 9350 19 fluorescence fluorescence NN cord-010119-t1x9gknd 9350 20 using use VBG cord-010119-t1x9gknd 9350 21 a a DT cord-010119-t1x9gknd 9350 22 microplate microplate JJ cord-010119-t1x9gknd 9350 23 reader reader NN cord-010119-t1x9gknd 9350 24 . . . cord-010119-t1x9gknd 9351 1 Results/ Results/ . cord-010119-t1x9gknd 9352 1 Finding finding NN cord-010119-t1x9gknd 9352 2 : : : cord-010119-t1x9gknd 9353 1 One one CD cord-010119-t1x9gknd 9353 2 original original JJ cord-010119-t1x9gknd 9353 3 generic generic JJ cord-010119-t1x9gknd 9353 4 probe probe NN cord-010119-t1x9gknd 9353 5 for for IN cord-010119-t1x9gknd 9353 6 DENV DENV NNP cord-010119-t1x9gknd 9353 7 and and CC cord-010119-t1x9gknd 9353 8 specific specific JJ cord-010119-t1x9gknd 9353 9 probes probe NNS cord-010119-t1x9gknd 9353 10 designed design VBN cord-010119-t1x9gknd 9353 11 for for IN cord-010119-t1x9gknd 9353 12 each each DT cord-010119-t1x9gknd 9353 13 of of IN cord-010119-t1x9gknd 9353 14 the the DT cord-010119-t1x9gknd 9353 15 four four CD cord-010119-t1x9gknd 9353 16 DENV DENV NNP cord-010119-t1x9gknd 9353 17 serotype serotype NN cord-010119-t1x9gknd 9353 18 , , , cord-010119-t1x9gknd 9353 19 WNV WNV NNP cord-010119-t1x9gknd 9353 20 , , , cord-010119-t1x9gknd 9353 21 the the DT cord-010119-t1x9gknd 9353 22 two two CD cord-010119-t1x9gknd 9353 23 ZIKV ZIKV NNP cord-010119-t1x9gknd 9353 24 lineages lineage NNS cord-010119-t1x9gknd 9353 25 and and CC cord-010119-t1x9gknd 9353 26 for for IN cord-010119-t1x9gknd 9353 27 CHIKV CHIKV NNP cord-010119-t1x9gknd 9353 28 , , , cord-010119-t1x9gknd 9353 29 were be VBD cord-010119-t1x9gknd 9353 30 validated validate VBN cord-010119-t1x9gknd 9353 31 . . . cord-010119-t1x9gknd 9354 1 The the DT cord-010119-t1x9gknd 9354 2 use use NN cord-010119-t1x9gknd 9354 3 of of IN cord-010119-t1x9gknd 9354 4 our -PRON- PRP$ cord-010119-t1x9gknd 9354 5 methodology methodology NN cord-010119-t1x9gknd 9354 6 combining combine VBG cord-010119-t1x9gknd 9354 7 the the DT cord-010119-t1x9gknd 9354 8 amplification amplification NN cord-010119-t1x9gknd 9354 9 of of IN cord-010119-t1x9gknd 9354 10 the the DT cord-010119-t1x9gknd 9354 11 viral viral JJ cord-010119-t1x9gknd 9354 12 genomes genome NNS cord-010119-t1x9gknd 9354 13 and and CC cord-010119-t1x9gknd 9354 14 their -PRON- PRP$ cord-010119-t1x9gknd 9354 15 identification identification NN cord-010119-t1x9gknd 9354 16 using use VBG cord-010119-t1x9gknd 9354 17 polythiolated polythiolate VBN cord-010119-t1x9gknd 9354 18 probes probe NNS cord-010119-t1x9gknd 9354 19 shows show VBZ cord-010119-t1x9gknd 9354 20 100 100 CD cord-010119-t1x9gknd 9354 21 % % NN cord-010119-t1x9gknd 9354 22 of of IN cord-010119-t1x9gknd 9354 23 specificity specificity NN cord-010119-t1x9gknd 9354 24 , , , cord-010119-t1x9gknd 9354 25 with with IN cord-010119-t1x9gknd 9354 26 no no DT cord-010119-t1x9gknd 9354 27 false false JJ cord-010119-t1x9gknd 9354 28 positive positive JJ cord-010119-t1x9gknd 9354 29 results result NNS cord-010119-t1x9gknd 9354 30 on on IN cord-010119-t1x9gknd 9354 31 the the DT cord-010119-t1x9gknd 9354 32 40 40 CD cord-010119-t1x9gknd 9354 33 control control NN cord-010119-t1x9gknd 9354 34 samples sample NNS cord-010119-t1x9gknd 9354 35 , , , cord-010119-t1x9gknd 9354 36 and and CC cord-010119-t1x9gknd 9354 37 no no DT cord-010119-t1x9gknd 9354 38 cross cross NN cord-010119-t1x9gknd 9354 39 reactions reaction NNS cord-010119-t1x9gknd 9354 40 . . . cord-010119-t1x9gknd 9355 1 Using use VBG cord-010119-t1x9gknd 9355 2 viral viral JJ cord-010119-t1x9gknd 9355 3 reference reference NN cord-010119-t1x9gknd 9355 4 standards standard NNS cord-010119-t1x9gknd 9355 5 , , , cord-010119-t1x9gknd 9355 6 we -PRON- PRP cord-010119-t1x9gknd 9355 7 have have VBP cord-010119-t1x9gknd 9355 8 observed observe VBN cord-010119-t1x9gknd 9355 9 sensitivities sensitivity NNS cord-010119-t1x9gknd 9355 10 of of IN cord-010119-t1x9gknd 9355 11 1 1 CD cord-010119-t1x9gknd 9355 12 TCID TCID NNP cord-010119-t1x9gknd 9355 13 50 50 CD cord-010119-t1x9gknd 9355 14 /mL /mL : cord-010119-t1x9gknd 9355 15 for for IN cord-010119-t1x9gknd 9355 16 DENV-1 DENV-1 NNS cord-010119-t1x9gknd 9355 17 , , , cord-010119-t1x9gknd 9355 18 DENV-3 DENV-3 NNP cord-010119-t1x9gknd 9355 19 and and CC cord-010119-t1x9gknd 9355 20 CHIKV CHIKV NNP cord-010119-t1x9gknd 9355 21 and and CC cord-010119-t1x9gknd 9355 22 of of IN cord-010119-t1x9gknd 9355 23 10 10 CD cord-010119-t1x9gknd 9355 24 TCID TCID NNP cord-010119-t1x9gknd 9355 25 50 50 CD cord-010119-t1x9gknd 9355 26 /mL /mL NFP cord-010119-t1x9gknd 9355 27 for for IN cord-010119-t1x9gknd 9355 28 DENV-2 DENV-2 NNP cord-010119-t1x9gknd 9355 29 , , , cord-010119-t1x9gknd 9355 30 DENV-4 DENV-4 NNP cord-010119-t1x9gknd 9355 31 and and CC cord-010119-t1x9gknd 9355 32 ZIKV ZIKV NNP cord-010119-t1x9gknd 9355 33 . . . cord-010119-t1x9gknd 9356 1 Finally finally RB cord-010119-t1x9gknd 9356 2 , , , cord-010119-t1x9gknd 9356 3 the the DT cord-010119-t1x9gknd 9356 4 first first JJ cord-010119-t1x9gknd 9356 5 results result NNS cord-010119-t1x9gknd 9356 6 obtained obtain VBN cord-010119-t1x9gknd 9356 7 on on IN cord-010119-t1x9gknd 9356 8 110 110 CD cord-010119-t1x9gknd 9356 9 DENV(1 DENV(1 NNP cord-010119-t1x9gknd 9356 10 ) ) -RRB- cord-010119-t1x9gknd 9356 11 , , , cord-010119-t1x9gknd 9356 12 69 69 CD cord-010119-t1x9gknd 9356 13 ZIKV(1 ZIKV(1 NNP cord-010119-t1x9gknd 9356 14 ) ) -RRB- cord-010119-t1x9gknd 9356 15 and and CC cord-010119-t1x9gknd 9356 16 50 50 CD cord-010119-t1x9gknd 9356 17 CHIKV(1 CHIKV(1 NNS cord-010119-t1x9gknd 9356 18 ) ) -RRB- cord-010119-t1x9gknd 9357 1 clinical clinical JJ cord-010119-t1x9gknd 9357 2 samples sample NNS cord-010119-t1x9gknd 9357 3 show show VBP cord-010119-t1x9gknd 9357 4 85 85 CD cord-010119-t1x9gknd 9357 5 % % NN cord-010119-t1x9gknd 9357 6 , , , cord-010119-t1x9gknd 9357 7 87 87 CD cord-010119-t1x9gknd 9357 8 % % NN cord-010119-t1x9gknd 9357 9 and and CC cord-010119-t1x9gknd 9357 10 96 96 CD cord-010119-t1x9gknd 9357 11 % % NN cord-010119-t1x9gknd 9357 12 correlation correlation NN cord-010119-t1x9gknd 9357 13 respectively respectively RB cord-010119-t1x9gknd 9357 14 between between IN cord-010119-t1x9gknd 9357 15 our -PRON- PRP$ cord-010119-t1x9gknd 9357 16 approach approach NN cord-010119-t1x9gknd 9357 17 and and CC cord-010119-t1x9gknd 9357 18 commercial commercial JJ cord-010119-t1x9gknd 9357 19 or or CC cord-010119-t1x9gknd 9357 20 in in IN cord-010119-t1x9gknd 9357 21 house house NN cord-010119-t1x9gknd 9357 22 real real JJ cord-010119-t1x9gknd 9357 23 time time NN cord-010119-t1x9gknd 9357 24 RT RT NNP cord-010119-t1x9gknd 9357 25 - - HYPH cord-010119-t1x9gknd 9357 26 PCR PCR NNP cord-010119-t1x9gknd 9357 27 methods method NNS cord-010119-t1x9gknd 9357 28 . . . cord-010119-t1x9gknd 9358 1 Conclusion conclusion NN cord-010119-t1x9gknd 9358 2 : : : cord-010119-t1x9gknd 9359 1 This this DT cord-010119-t1x9gknd 9359 2 innovative innovative JJ cord-010119-t1x9gknd 9359 3 strategy strategy NN cord-010119-t1x9gknd 9359 4 allows allow VBZ cord-010119-t1x9gknd 9359 5 the the DT cord-010119-t1x9gknd 9359 6 development development NN cord-010119-t1x9gknd 9359 7 of of IN cord-010119-t1x9gknd 9359 8 flexible flexible JJ cord-010119-t1x9gknd 9359 9 , , , cord-010119-t1x9gknd 9359 10 highly highly RB cord-010119-t1x9gknd 9359 11 sensitive sensitive JJ cord-010119-t1x9gknd 9359 12 and and CC cord-010119-t1x9gknd 9359 13 easy easy JJ cord-010119-t1x9gknd 9359 14 to to TO cord-010119-t1x9gknd 9359 15 handle handle VB cord-010119-t1x9gknd 9359 16 platforms platform NNS cord-010119-t1x9gknd 9359 17 dedicated dedicate VBN cord-010119-t1x9gknd 9359 18 to to IN cord-010119-t1x9gknd 9359 19 the the DT cord-010119-t1x9gknd 9359 20 multiplex multiplex NN cord-010119-t1x9gknd 9359 21 screening screening NN cord-010119-t1x9gknd 9359 22 and and CC cord-010119-t1x9gknd 9359 23 identification identification NN cord-010119-t1x9gknd 9359 24 of of IN cord-010119-t1x9gknd 9359 25 emerging emerge VBG cord-010119-t1x9gknd 9359 26 viruses virus NNS cord-010119-t1x9gknd 9359 27 . . . cord-010119-t1x9gknd 9360 1 This this DT cord-010119-t1x9gknd 9360 2 methodology methodology NN cord-010119-t1x9gknd 9360 3 is be VBZ cord-010119-t1x9gknd 9360 4 adapted adapt VBN cord-010119-t1x9gknd 9360 5 for for IN cord-010119-t1x9gknd 9360 6 the the DT cord-010119-t1x9gknd 9360 7 easy easy JJ cord-010119-t1x9gknd 9360 8 inclusion inclusion NN cord-010119-t1x9gknd 9360 9 of of IN cord-010119-t1x9gknd 9360 10 additional additional JJ cord-010119-t1x9gknd 9360 11 molecular molecular JJ cord-010119-t1x9gknd 9360 12 targets target NNS cord-010119-t1x9gknd 9360 13 to to TO cord-010119-t1x9gknd 9360 14 improve improve VB cord-010119-t1x9gknd 9360 15 the the DT cord-010119-t1x9gknd 9360 16 surveillance surveillance NN cord-010119-t1x9gknd 9360 17 and and CC cord-010119-t1x9gknd 9360 18 the the DT cord-010119-t1x9gknd 9360 19 prevention prevention NN cord-010119-t1x9gknd 9360 20 of of IN cord-010119-t1x9gknd 9360 21 arboviral arboviral NNP cord-010119-t1x9gknd 9360 22 infections infection NNS cord-010119-t1x9gknd 9360 23 . . . cord-010119-t1x9gknd 9361 1 Babesia Babesia NNP cord-010119-t1x9gknd 9361 2 Microti Microti NNP cord-010119-t1x9gknd 9361 3 Serological Serological NNP cord-010119-t1x9gknd 9361 4 Testing test VBG cord-010119-t1x9gknd 9361 5 with with IN cord-010119-t1x9gknd 9361 6 Pooled pool VBN cord-010119-t1x9gknd 9361 7 Samples sample NNS cord-010119-t1x9gknd 9361 8 : : : cord-010119-t1x9gknd 9362 1 A a DT cord-010119-t1x9gknd 9362 2 Feasibility Feasibility NNP cord-010119-t1x9gknd 9362 3 Study Study NNP cord-010119-t1x9gknd 9362 4 Laura Laura NNP cord-010119-t1x9gknd 9362 5 Tonnetti Tonnetti NNP cord-010119-t1x9gknd 9362 6 * * NFP cord-010119-t1x9gknd 9362 7 , , , cord-010119-t1x9gknd 9362 8 Aaron Aaron NNP cord-010119-t1x9gknd 9362 9 Thorp Thorp NNP cord-010119-t1x9gknd 9362 10 , , , cord-010119-t1x9gknd 9362 11 Letitia Letitia NNP cord-010119-t1x9gknd 9362 12 Dixon Dixon NNP cord-010119-t1x9gknd 9362 13 and and CC cord-010119-t1x9gknd 9362 14 Susan Susan NNP cord-010119-t1x9gknd 9362 15 L L NNP cord-010119-t1x9gknd 9362 16 Stramer Stramer NNP cord-010119-t1x9gknd 9362 17 . . . cord-010119-t1x9gknd 9363 1 Background Background NNP cord-010119-t1x9gknd 9363 2 / / SYM cord-010119-t1x9gknd 9363 3 Case Case NNP cord-010119-t1x9gknd 9363 4 Studies Studies NNPS cord-010119-t1x9gknd 9363 5 : : : cord-010119-t1x9gknd 9363 6 Blood blood NN cord-010119-t1x9gknd 9363 7 donation donation NN cord-010119-t1x9gknd 9363 8 screening screening NN cord-010119-t1x9gknd 9363 9 for for IN cord-010119-t1x9gknd 9363 10 Babesia Babesia NNP cord-010119-t1x9gknd 9363 11 microti microti NN cord-010119-t1x9gknd 9363 12 , , , cord-010119-t1x9gknd 9363 13 a a DT cord-010119-t1x9gknd 9363 14 tick tick VB cord-010119-t1x9gknd 9363 15 - - HYPH cord-010119-t1x9gknd 9363 16 borne bear VBN cord-010119-t1x9gknd 9363 17 intraerythrocytic intraerythrocytic JJ cord-010119-t1x9gknd 9363 18 parasite parasite NN cord-010119-t1x9gknd 9363 19 endemic endemic JJ cord-010119-t1x9gknd 9363 20 in in IN cord-010119-t1x9gknd 9363 21 the the DT cord-010119-t1x9gknd 9363 22 Northeast Northeast NNP cord-010119-t1x9gknd 9363 23 and and CC cord-010119-t1x9gknd 9363 24 Upper Upper NNP cord-010119-t1x9gknd 9363 25 Midwest Midwest NNP cord-010119-t1x9gknd 9363 26 US US NNP cord-010119-t1x9gknd 9363 27 , , , cord-010119-t1x9gknd 9363 28 is be VBZ cord-010119-t1x9gknd 9363 29 performed perform VBN cord-010119-t1x9gknd 9363 30 under under IN cord-010119-t1x9gknd 9363 31 an an DT cord-010119-t1x9gknd 9363 32 investigational investigational JJ cord-010119-t1x9gknd 9363 33 study study NN cord-010119-t1x9gknd 9363 34 using use VBG cord-010119-t1x9gknd 9363 35 nucleic nucleic JJ cord-010119-t1x9gknd 9363 36 acid acid NN cord-010119-t1x9gknd 9363 37 and and CC cord-010119-t1x9gknd 9363 38 immunofluorescence immunofluorescence NN cord-010119-t1x9gknd 9363 39 assays assay NNS cord-010119-t1x9gknd 9363 40 ( ( -LRB- cord-010119-t1x9gknd 9363 41 IFA IFA NNP cord-010119-t1x9gknd 9363 42 ) ) -RRB- cord-010119-t1x9gknd 9363 43 . . . cord-010119-t1x9gknd 9364 1 However however RB cord-010119-t1x9gknd 9364 2 , , , cord-010119-t1x9gknd 9364 3 IFA IFA NNP cord-010119-t1x9gknd 9364 4 is be VBZ cord-010119-t1x9gknd 9364 5 a a DT cord-010119-t1x9gknd 9364 6 time time NN cord-010119-t1x9gknd 9364 7 consuming consume VBG cord-010119-t1x9gknd 9364 8 and and CC cord-010119-t1x9gknd 9364 9 labor labor NN cord-010119-t1x9gknd 9364 10 intensive intensive JJ cord-010119-t1x9gknd 9364 11 procedure procedure NN cord-010119-t1x9gknd 9364 12 . . . cord-010119-t1x9gknd 9365 1 With with IN cord-010119-t1x9gknd 9365 2 the the DT cord-010119-t1x9gknd 9365 3 possibility possibility NN cord-010119-t1x9gknd 9365 4 of of IN cord-010119-t1x9gknd 9365 5 an an DT cord-010119-t1x9gknd 9365 6 FDA FDA NNP cord-010119-t1x9gknd 9365 7 licensed license VBN cord-010119-t1x9gknd 9365 8 screening screening NN cord-010119-t1x9gknd 9365 9 assay(s assay(s NN cord-010119-t1x9gknd 9365 10 ) ) -RRB- cord-010119-t1x9gknd 9365 11 in in IN cord-010119-t1x9gknd 9365 12 the the DT cord-010119-t1x9gknd 9365 13 near near JJ cord-010119-t1x9gknd 9365 14 future future NN cord-010119-t1x9gknd 9365 15 , , , cord-010119-t1x9gknd 9365 16 we -PRON- PRP cord-010119-t1x9gknd 9365 17 investigated investigate VBD cord-010119-t1x9gknd 9365 18 if if IN cord-010119-t1x9gknd 9365 19 B. B. NNP cord-010119-t1x9gknd 9365 20 microti microti NN cord-010119-t1x9gknd 9365 21 testing testing NN cord-010119-t1x9gknd 9365 22 by by IN cord-010119-t1x9gknd 9365 23 IFA IFA NNP cord-010119-t1x9gknd 9365 24 in in IN cord-010119-t1x9gknd 9365 25 pools pool NNS cord-010119-t1x9gknd 9365 26 of of IN cord-010119-t1x9gknd 9365 27 plasma plasma NN cord-010119-t1x9gknd 9365 28 or or CC cord-010119-t1x9gknd 9365 29 serum serum NN cord-010119-t1x9gknd 9365 30 could could MD cord-010119-t1x9gknd 9365 31 be be VB cord-010119-t1x9gknd 9365 32 a a DT cord-010119-t1x9gknd 9365 33 feasible feasible JJ cord-010119-t1x9gknd 9365 34 screening screening NN cord-010119-t1x9gknd 9365 35 approach approach NN cord-010119-t1x9gknd 9365 36 . . . cord-010119-t1x9gknd 9366 1 Study Study NNP cord-010119-t1x9gknd 9366 2 Design Design NNP cord-010119-t1x9gknd 9366 3 / / SYM cord-010119-t1x9gknd 9366 4 Method method NN cord-010119-t1x9gknd 9366 5 : : : cord-010119-t1x9gknd 9367 1 To to TO cord-010119-t1x9gknd 9367 2 test test VB cord-010119-t1x9gknd 9367 3 if if IN cord-010119-t1x9gknd 9367 4 the the DT cord-010119-t1x9gknd 9367 5 increased increase VBN cord-010119-t1x9gknd 9367 6 amount amount NN cord-010119-t1x9gknd 9367 7 of of IN cord-010119-t1x9gknd 9367 8 plasma plasma NN cord-010119-t1x9gknd 9367 9 or or CC cord-010119-t1x9gknd 9367 10 serum serum NN cord-010119-t1x9gknd 9367 11 interferes interfere VBZ cord-010119-t1x9gknd 9367 12 with with IN cord-010119-t1x9gknd 9367 13 background background NN cord-010119-t1x9gknd 9367 14 fluorescence fluorescence NN cord-010119-t1x9gknd 9367 15 , , , cord-010119-t1x9gknd 9367 16 pools pool NNS cord-010119-t1x9gknd 9367 17 of of IN cord-010119-t1x9gknd 9367 18 4 4 CD cord-010119-t1x9gknd 9367 19 , , , cord-010119-t1x9gknd 9367 20 8 8 CD cord-010119-t1x9gknd 9367 21 , , , cord-010119-t1x9gknd 9367 22 16 16 CD cord-010119-t1x9gknd 9367 23 and and CC cord-010119-t1x9gknd 9367 24 32 32 CD cord-010119-t1x9gknd 9367 25 were be VBD cord-010119-t1x9gknd 9367 26 prepared prepare VBN cord-010119-t1x9gknd 9367 27 from from IN cord-010119-t1x9gknd 9367 28 192 192 CD cord-010119-t1x9gknd 9367 29 plasma plasma NN cord-010119-t1x9gknd 9367 30 or or CC cord-010119-t1x9gknd 9367 31 192 192 CD cord-010119-t1x9gknd 9367 32 serum serum NN cord-010119-t1x9gknd 9367 33 samples sample NNS cord-010119-t1x9gknd 9367 34 determined determine VBN cord-010119-t1x9gknd 9367 35 to to IN cord-010119-t1x9gknd 9367 36 B. B. NNP cord-010119-t1x9gknd 9367 37 microti microti JJ cord-010119-t1x9gknd 9367 38 - - HYPH cord-010119-t1x9gknd 9367 39 negative negative JJ cord-010119-t1x9gknd 9367 40 by by IN cord-010119-t1x9gknd 9367 41 individual individual JJ cord-010119-t1x9gknd 9367 42 IFA IFA NNP cord-010119-t1x9gknd 9367 43 screening screening NN cord-010119-t1x9gknd 9367 44 . . . cord-010119-t1x9gknd 9368 1 The the DT cord-010119-t1x9gknd 9368 2 pools pool NNS cord-010119-t1x9gknd 9368 3 were be VBD cord-010119-t1x9gknd 9368 4 tested test VBN cord-010119-t1x9gknd 9368 5 by by IN cord-010119-t1x9gknd 9368 6 IFA IFA NNP cord-010119-t1x9gknd 9368 7 with with IN cord-010119-t1x9gknd 9368 8 or or CC cord-010119-t1x9gknd 9368 9 without without IN cord-010119-t1x9gknd 9368 10 a a DT cord-010119-t1x9gknd 9368 11 blocking block VBG cord-010119-t1x9gknd 9368 12 step step NN cord-010119-t1x9gknd 9368 13 using use VBG cord-010119-t1x9gknd 9368 14 bovine bovine JJ cord-010119-t1x9gknd 9368 15 serum serum NN cord-010119-t1x9gknd 9368 16 albumin albumin NN cord-010119-t1x9gknd 9368 17 ( ( -LRB- cord-010119-t1x9gknd 9368 18 BSA BSA NNP cord-010119-t1x9gknd 9368 19 ) ) -RRB- cord-010119-t1x9gknd 9368 20 and and CC cord-010119-t1x9gknd 9368 21 goat goat NN cord-010119-t1x9gknd 9368 22 serum serum NN cord-010119-t1x9gknd 9368 23 to to TO cord-010119-t1x9gknd 9368 24 minimize minimize VB cord-010119-t1x9gknd 9368 25 background background NN cord-010119-t1x9gknd 9368 26 fluorescence fluorescence NN cord-010119-t1x9gknd 9368 27 . . . cord-010119-t1x9gknd 9369 1 Potential potential JJ cord-010119-t1x9gknd 9369 2 interference interference NN cord-010119-t1x9gknd 9369 3 from from IN cord-010119-t1x9gknd 9369 4 multiple multiple JJ cord-010119-t1x9gknd 9369 5 pooled pooled JJ cord-010119-t1x9gknd 9369 6 plasma plasma NN cord-010119-t1x9gknd 9369 7 or or CC cord-010119-t1x9gknd 9369 8 serum serum NN cord-010119-t1x9gknd 9369 9 samples sample NNS cord-010119-t1x9gknd 9369 10 on on IN cord-010119-t1x9gknd 9369 11 the the DT cord-010119-t1x9gknd 9369 12 endpoint endpoint NN cord-010119-t1x9gknd 9369 13 titer titer NN cord-010119-t1x9gknd 9369 14 of of IN cord-010119-t1x9gknd 9369 15 positive positive JJ cord-010119-t1x9gknd 9369 16 samples sample NNS cord-010119-t1x9gknd 9369 17 was be VBD cord-010119-t1x9gknd 9369 18 investigated investigate VBN cord-010119-t1x9gknd 9369 19 by by IN cord-010119-t1x9gknd 9369 20 including include VBG cord-010119-t1x9gknd 9369 21 positive positive JJ cord-010119-t1x9gknd 9369 22 samples sample NNS cord-010119-t1x9gknd 9369 23 with with IN cord-010119-t1x9gknd 9369 24 endpoint endpoint NN cord-010119-t1x9gknd 9369 25 titers titer NNS cord-010119-t1x9gknd 9369 26 from from IN cord-010119-t1x9gknd 9369 27 1:128 1:128 CD cord-010119-t1x9gknd 9369 28 to to IN cord-010119-t1x9gknd 9369 29 1:1024 1:1024 CD cord-010119-t1x9gknd 9369 30 ( ( -LRB- cord-010119-t1x9gknd 9369 31 2-fold 2-fold CD cord-010119-t1x9gknd 9369 32 dilutions dilution NNS cord-010119-t1x9gknd 9369 33 ) ) -RRB- cord-010119-t1x9gknd 9369 34 in in IN cord-010119-t1x9gknd 9369 35 the the DT cord-010119-t1x9gknd 9369 36 pools pool NNS cord-010119-t1x9gknd 9369 37 . . . cord-010119-t1x9gknd 9370 1 Results/ Results/ . cord-010119-t1x9gknd 9371 1 Finding finding NN cord-010119-t1x9gknd 9371 2 : : : cord-010119-t1x9gknd 9372 1 Non non JJ cord-010119-t1x9gknd 9372 2 - - JJ cord-010119-t1x9gknd 9372 3 specific specific JJ cord-010119-t1x9gknd 9372 4 fluorescence fluorescence NN cord-010119-t1x9gknd 9372 5 was be VBD cord-010119-t1x9gknd 9372 6 visible visible JJ cord-010119-t1x9gknd 9372 7 in in IN cord-010119-t1x9gknd 9372 8 pools pool NNS cord-010119-t1x9gknd 9372 9 of of IN cord-010119-t1x9gknd 9372 10 16 16 CD cord-010119-t1x9gknd 9372 11 or or CC cord-010119-t1x9gknd 9372 12 higher high JJR cord-010119-t1x9gknd 9372 13 and and CC cord-010119-t1x9gknd 9372 14 was be VBD cord-010119-t1x9gknd 9372 15 not not RB cord-010119-t1x9gknd 9372 16 eliminated eliminate VBN cord-010119-t1x9gknd 9372 17 by by IN cord-010119-t1x9gknd 9372 18 the the DT cord-010119-t1x9gknd 9372 19 addition addition NN cord-010119-t1x9gknd 9372 20 of of IN cord-010119-t1x9gknd 9372 21 a a DT cord-010119-t1x9gknd 9372 22 blocking block VBG cord-010119-t1x9gknd 9372 23 step step NN cord-010119-t1x9gknd 9372 24 . . . cord-010119-t1x9gknd 9373 1 Pools pool NNS cord-010119-t1x9gknd 9373 2 of of IN cord-010119-t1x9gknd 9373 3 4 4 CD cord-010119-t1x9gknd 9373 4 or or CC cord-010119-t1x9gknd 9373 5 8 8 CD cord-010119-t1x9gknd 9373 6 samples sample NNS cord-010119-t1x9gknd 9373 7 did do VBD cord-010119-t1x9gknd 9373 8 not not RB cord-010119-t1x9gknd 9373 9 show show VB cord-010119-t1x9gknd 9373 10 significant significant JJ cord-010119-t1x9gknd 9373 11 increased increase VBN cord-010119-t1x9gknd 9373 12 background background NN cord-010119-t1x9gknd 9373 13 . . . cord-010119-t1x9gknd 9374 1 There there EX cord-010119-t1x9gknd 9374 2 was be VBD cord-010119-t1x9gknd 9374 3 no no DT cord-010119-t1x9gknd 9374 4 difference difference NN cord-010119-t1x9gknd 9374 5 between between IN cord-010119-t1x9gknd 9374 6 testing testing NN cord-010119-t1x9gknd 9374 7 of of IN cord-010119-t1x9gknd 9374 8 pooled pool VBN cord-010119-t1x9gknd 9374 9 serum serum NN cord-010119-t1x9gknd 9374 10 or or CC cord-010119-t1x9gknd 9374 11 plasma plasma NN cord-010119-t1x9gknd 9374 12 samples sample NNS cord-010119-t1x9gknd 9374 13 . . . cord-010119-t1x9gknd 9375 1 When when WRB cord-010119-t1x9gknd 9375 2 one one CD cord-010119-t1x9gknd 9375 3 single single JJ cord-010119-t1x9gknd 9375 4 positive positive JJ cord-010119-t1x9gknd 9375 5 sample sample NN cord-010119-t1x9gknd 9375 6 was be VBD cord-010119-t1x9gknd 9375 7 included include VBN cord-010119-t1x9gknd 9375 8 in in IN cord-010119-t1x9gknd 9375 9 the the DT cord-010119-t1x9gknd 9375 10 pools pool NNS cord-010119-t1x9gknd 9375 11 of of IN cord-010119-t1x9gknd 9375 12 4 4 CD cord-010119-t1x9gknd 9375 13 or or CC cord-010119-t1x9gknd 9375 14 8 8 CD cord-010119-t1x9gknd 9375 15 samples sample NNS cord-010119-t1x9gknd 9375 16 , , , cord-010119-t1x9gknd 9375 17 the the DT cord-010119-t1x9gknd 9375 18 pool pool NN cord-010119-t1x9gknd 9375 19 tested test VBD cord-010119-t1x9gknd 9375 20 positive positive JJ cord-010119-t1x9gknd 9375 21 and and CC cord-010119-t1x9gknd 9375 22 the the DT cord-010119-t1x9gknd 9375 23 final final JJ cord-010119-t1x9gknd 9375 24 titer titer NN cord-010119-t1x9gknd 9375 25 was be VBD cord-010119-t1x9gknd 9375 26 the the DT cord-010119-t1x9gknd 9375 27 same same JJ cord-010119-t1x9gknd 9375 28 as as IN cord-010119-t1x9gknd 9375 29 the the DT cord-010119-t1x9gknd 9375 30 positive positive JJ cord-010119-t1x9gknd 9375 31 sample sample NN cord-010119-t1x9gknd 9375 32 tested test VBN cord-010119-t1x9gknd 9375 33 individually individually RB cord-010119-t1x9gknd 9375 34 . . . cord-010119-t1x9gknd 9376 1 When when WRB cord-010119-t1x9gknd 9376 2 two two CD cord-010119-t1x9gknd 9376 3 or or CC cord-010119-t1x9gknd 9376 4 more more RBR cord-010119-t1x9gknd 9376 5 positive positive JJ cord-010119-t1x9gknd 9376 6 samples sample NNS cord-010119-t1x9gknd 9376 7 were be VBD cord-010119-t1x9gknd 9376 8 included include VBN cord-010119-t1x9gknd 9376 9 in in IN cord-010119-t1x9gknd 9376 10 the the DT cord-010119-t1x9gknd 9376 11 pools pool NNS cord-010119-t1x9gknd 9376 12 , , , cord-010119-t1x9gknd 9376 13 the the DT cord-010119-t1x9gknd 9376 14 final final JJ cord-010119-t1x9gknd 9376 15 titer titer NN cord-010119-t1x9gknd 9376 16 of of IN cord-010119-t1x9gknd 9376 17 the the DT cord-010119-t1x9gknd 9376 18 pools pool NNS cord-010119-t1x9gknd 9376 19 was be VBD cord-010119-t1x9gknd 9376 20 equal equal JJ cord-010119-t1x9gknd 9376 21 to to IN cord-010119-t1x9gknd 9376 22 the the DT cord-010119-t1x9gknd 9376 23 sample sample NN cord-010119-t1x9gknd 9376 24 with with IN cord-010119-t1x9gknd 9376 25 the the DT cord-010119-t1x9gknd 9376 26 highest high JJS cord-010119-t1x9gknd 9376 27 titer titer NN cord-010119-t1x9gknd 9376 28 . . . cord-010119-t1x9gknd 9377 1 Conclusion conclusion NN cord-010119-t1x9gknd 9377 2 : : : cord-010119-t1x9gknd 9378 1 This this DT cord-010119-t1x9gknd 9378 2 study study NN cord-010119-t1x9gknd 9378 3 represents represent VBZ cord-010119-t1x9gknd 9378 4 a a DT cord-010119-t1x9gknd 9378 5 proof proof NN cord-010119-t1x9gknd 9378 6 of of IN cord-010119-t1x9gknd 9378 7 concept concept NN cord-010119-t1x9gknd 9378 8 that that IN cord-010119-t1x9gknd 9378 9 serological serological JJ cord-010119-t1x9gknd 9378 10 testing testing NN cord-010119-t1x9gknd 9378 11 for for IN cord-010119-t1x9gknd 9378 12 B. B. NNP cord-010119-t1x9gknd 9378 13 microti microti NN cord-010119-t1x9gknd 9378 14 by by IN cord-010119-t1x9gknd 9378 15 IFA IFA NNP cord-010119-t1x9gknd 9378 16 in in IN cord-010119-t1x9gknd 9378 17 pools pool NNS cord-010119-t1x9gknd 9378 18 of of IN cord-010119-t1x9gknd 9378 19 up up IN cord-010119-t1x9gknd 9378 20 to to TO cord-010119-t1x9gknd 9378 21 8 8 CD cord-010119-t1x9gknd 9378 22 plasma plasma NN cord-010119-t1x9gknd 9378 23 or or CC cord-010119-t1x9gknd 9378 24 serum serum NN cord-010119-t1x9gknd 9378 25 samples sample NNS cord-010119-t1x9gknd 9378 26 does do VBZ cord-010119-t1x9gknd 9378 27 not not RB cord-010119-t1x9gknd 9378 28 increase increase VB cord-010119-t1x9gknd 9378 29 false false JJ cord-010119-t1x9gknd 9378 30 positivity positivity NN cord-010119-t1x9gknd 9378 31 while while IN cord-010119-t1x9gknd 9378 32 maintaining maintain VBG cord-010119-t1x9gknd 9378 33 the the DT cord-010119-t1x9gknd 9378 34 sensitivity sensitivity NN cord-010119-t1x9gknd 9378 35 of of IN cord-010119-t1x9gknd 9378 36 the the DT cord-010119-t1x9gknd 9378 37 test test NN cord-010119-t1x9gknd 9378 38 . . . cord-010119-t1x9gknd 9379 1 Background Background NNP cord-010119-t1x9gknd 9379 2 / / SYM cord-010119-t1x9gknd 9379 3 Case Case NNP cord-010119-t1x9gknd 9379 4 Studies Studies NNPS cord-010119-t1x9gknd 9379 5 : : : cord-010119-t1x9gknd 9380 1 The the DT cord-010119-t1x9gknd 9380 2 rapid rapid JJ cord-010119-t1x9gknd 9380 3 detection detection NN cord-010119-t1x9gknd 9380 4 of of IN cord-010119-t1x9gknd 9380 5 bacterial bacterial JJ cord-010119-t1x9gknd 9380 6 contamination contamination NN cord-010119-t1x9gknd 9380 7 in in IN cord-010119-t1x9gknd 9380 8 platelets platelet NNS cord-010119-t1x9gknd 9380 9 is be VBZ cord-010119-t1x9gknd 9380 10 key key JJ cord-010119-t1x9gknd 9380 11 to to IN cord-010119-t1x9gknd 9380 12 reducing reduce VBG cord-010119-t1x9gknd 9380 13 the the DT cord-010119-t1x9gknd 9380 14 risk risk NN cord-010119-t1x9gknd 9380 15 of of IN cord-010119-t1x9gknd 9380 16 infection infection NN cord-010119-t1x9gknd 9380 17 in in IN cord-010119-t1x9gknd 9380 18 transfusion transfusion NN cord-010119-t1x9gknd 9380 19 of of IN cord-010119-t1x9gknd 9380 20 blood blood NN cord-010119-t1x9gknd 9380 21 components component NNS cord-010119-t1x9gknd 9380 22 . . . cord-010119-t1x9gknd 9381 1 The the DT cord-010119-t1x9gknd 9381 2 BacT BacT NNP cord-010119-t1x9gknd 9381 3 / / SYM cord-010119-t1x9gknd 9381 4 ALERT alert VBP cord-010119-t1x9gknd 9381 5 VIRTUO VIRTUO NNS cord-010119-t1x9gknd 9381 6 * * NFP cord-010119-t1x9gknd 9381 7 is be VBZ cord-010119-t1x9gknd 9381 8 an an DT cord-010119-t1x9gknd 9381 9 advanced advanced JJ cord-010119-t1x9gknd 9381 10 , , , cord-010119-t1x9gknd 9381 11 next next JJ cord-010119-t1x9gknd 9381 12 generation generation NN cord-010119-t1x9gknd 9381 13 system system NN cord-010119-t1x9gknd 9381 14 with with IN cord-010119-t1x9gknd 9381 15 improved improved JJ cord-010119-t1x9gknd 9381 16 automation automation NN cord-010119-t1x9gknd 9381 17 , , , cord-010119-t1x9gknd 9381 18 connectivity connectivity NN cord-010119-t1x9gknd 9381 19 and and CC cord-010119-t1x9gknd 9381 20 with with IN cord-010119-t1x9gknd 9381 21 data datum NNS cord-010119-t1x9gknd 9381 22 management management NN cord-010119-t1x9gknd 9381 23 systems system NNS cord-010119-t1x9gknd 9381 24 . . . cord-010119-t1x9gknd 9382 1 The the DT cord-010119-t1x9gknd 9382 2 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9382 3 's 's POS cord-010119-t1x9gknd 9382 4 new new JJ cord-010119-t1x9gknd 9382 5 algorithm algorithm NN cord-010119-t1x9gknd 9382 6 significantly significantly RB cord-010119-t1x9gknd 9382 7 reduces reduce VBZ cord-010119-t1x9gknd 9382 8 the the DT cord-010119-t1x9gknd 9382 9 time time NN cord-010119-t1x9gknd 9382 10 to to IN cord-010119-t1x9gknd 9382 11 detection detection NN cord-010119-t1x9gknd 9382 12 ( ( -LRB- cord-010119-t1x9gknd 9382 13 TTD TTD NNP cord-010119-t1x9gknd 9382 14 ) ) -RRB- cord-010119-t1x9gknd 9382 15 of of IN cord-010119-t1x9gknd 9382 16 microorganisms microorganism NNS cord-010119-t1x9gknd 9382 17 during during IN cord-010119-t1x9gknd 9382 18 quality quality NN cord-010119-t1x9gknd 9382 19 control control NN cord-010119-t1x9gknd 9382 20 testing testing NN cord-010119-t1x9gknd 9382 21 of of IN cord-010119-t1x9gknd 9382 22 platelet platelet NN cord-010119-t1x9gknd 9382 23 preparations preparation NNS cord-010119-t1x9gknd 9382 24 using use VBG cord-010119-t1x9gknd 9382 25 BacT BacT NNP cord-010119-t1x9gknd 9382 26 / / SYM cord-010119-t1x9gknd 9382 27 ALERT ALERT NNP cord-010119-t1x9gknd 9382 28 ( ( -LRB- cord-010119-t1x9gknd 9382 29 BTA BTA NNP cord-010119-t1x9gknd 9382 30 ) ) -RRB- cord-010119-t1x9gknd 9382 31 BPA BPA NNP cord-010119-t1x9gknd 9382 32 ( ( -LRB- cord-010119-t1x9gknd 9382 33 aerobic aerobic NN cord-010119-t1x9gknd 9382 34 ) ) -RRB- cord-010119-t1x9gknd 9382 35 and and CC cord-010119-t1x9gknd 9382 36 BPN BPN NNP cord-010119-t1x9gknd 9382 37 ( ( -LRB- cord-010119-t1x9gknd 9382 38 anaerobic anaerobic JJ cord-010119-t1x9gknd 9382 39 ) ) -RRB- cord-010119-t1x9gknd 9382 40 bottles bottle NNS cord-010119-t1x9gknd 9382 41 . . . cord-010119-t1x9gknd 9383 1 As as IN cord-010119-t1x9gknd 9383 2 plasma plasma NN cord-010119-t1x9gknd 9383 3 is be VBZ cord-010119-t1x9gknd 9383 4 known know VBN cord-010119-t1x9gknd 9383 5 to to TO cord-010119-t1x9gknd 9383 6 be be VB cord-010119-t1x9gknd 9383 7 bactericidal bactericidal JJ cord-010119-t1x9gknd 9383 8 , , , cord-010119-t1x9gknd 9383 9 a a DT cord-010119-t1x9gknd 9383 10 study study NN cord-010119-t1x9gknd 9383 11 was be VBD cord-010119-t1x9gknd 9383 12 completed complete VBN cord-010119-t1x9gknd 9383 13 to to TO cord-010119-t1x9gknd 9383 14 evaluate evaluate VB cord-010119-t1x9gknd 9383 15 plasma plasma NN cord-010119-t1x9gknd 9383 16 susceptibility susceptibility NN cord-010119-t1x9gknd 9383 17 / / SYM cord-010119-t1x9gknd 9383 18 resistance resistance NN cord-010119-t1x9gknd 9383 19 for for IN cord-010119-t1x9gknd 9383 20 organisms organism NNS cord-010119-t1x9gknd 9383 21 considered consider VBN cord-010119-t1x9gknd 9383 22 for for IN cord-010119-t1x9gknd 9383 23 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9383 24 studies study NNS cord-010119-t1x9gknd 9383 25 . . . cord-010119-t1x9gknd 9384 1 Study Study NNP cord-010119-t1x9gknd 9384 2 Design Design NNP cord-010119-t1x9gknd 9384 3 / / SYM cord-010119-t1x9gknd 9384 4 Method method NN cord-010119-t1x9gknd 9384 5 : : : cord-010119-t1x9gknd 9385 1 Human human JJ cord-010119-t1x9gknd 9385 2 plasma plasma NN cord-010119-t1x9gknd 9385 3 ( ( -LRB- cord-010119-t1x9gknd 9385 4 thawed thaw VBN cord-010119-t1x9gknd 9385 5 and and CC cord-010119-t1x9gknd 9385 6 pooled pool VBN cord-010119-t1x9gknd 9385 7 ) ) -RRB- cord-010119-t1x9gknd 9385 8 and and CC cord-010119-t1x9gknd 9385 9 saline saline NN cord-010119-t1x9gknd 9385 10 controls control NNS cord-010119-t1x9gknd 9385 11 were be VBD cord-010119-t1x9gknd 9385 12 seeded seed VBN cord-010119-t1x9gknd 9385 13 with with IN cord-010119-t1x9gknd 9385 14 $ $ $ cord-010119-t1x9gknd 9385 15 100 100 CD cord-010119-t1x9gknd 9385 16 CFU CFU NNP cord-010119-t1x9gknd 9385 17 / / SYM cord-010119-t1x9gknd 9385 18 mL ml NN cord-010119-t1x9gknd 9385 19 of of IN cord-010119-t1x9gknd 9385 20 12 12 CD cord-010119-t1x9gknd 9385 21 organisms organism NNS cord-010119-t1x9gknd 9385 22 associated associate VBN cord-010119-t1x9gknd 9385 23 with with IN cord-010119-t1x9gknd 9385 24 platelet platelet NN cord-010119-t1x9gknd 9385 25 contamination contamination NN cord-010119-t1x9gknd 9385 26 and and CC cord-010119-t1x9gknd 9385 27 incubated incubate VBN cord-010119-t1x9gknd 9385 28 at at IN cord-010119-t1x9gknd 9385 29 room room NN cord-010119-t1x9gknd 9385 30 temperature temperature NN cord-010119-t1x9gknd 9385 31 for for IN cord-010119-t1x9gknd 9385 32 18 18 CD cord-010119-t1x9gknd 9385 33 - - SYM cord-010119-t1x9gknd 9385 34 24 24 CD cord-010119-t1x9gknd 9385 35 hours hour NNS cord-010119-t1x9gknd 9385 36 . . . cord-010119-t1x9gknd 9386 1 Colony colony NN cord-010119-t1x9gknd 9386 2 counts count NNS cord-010119-t1x9gknd 9386 3 were be VBD cord-010119-t1x9gknd 9386 4 performed perform VBN cord-010119-t1x9gknd 9386 5 initially initially RB cord-010119-t1x9gknd 9386 6 and and CC cord-010119-t1x9gknd 9386 7 after after IN cord-010119-t1x9gknd 9386 8 incubation incubation NN cord-010119-t1x9gknd 9386 9 . . . cord-010119-t1x9gknd 9387 1 Plasma plasma NN cord-010119-t1x9gknd 9387 2 resistance resistance NN cord-010119-t1x9gknd 9387 3 was be VBD cord-010119-t1x9gknd 9387 4 determined determine VBN cord-010119-t1x9gknd 9387 5 if if IN cord-010119-t1x9gknd 9387 6 the the DT cord-010119-t1x9gknd 9387 7 colony colony NN cord-010119-t1x9gknd 9387 8 count count NN cord-010119-t1x9gknd 9387 9 of of IN cord-010119-t1x9gknd 9387 10 the the DT cord-010119-t1x9gknd 9387 11 seeded seeded JJ cord-010119-t1x9gknd 9387 12 plasma plasma NN cord-010119-t1x9gknd 9387 13 was be VBD cord-010119-t1x9gknd 9387 14 equivalent equivalent JJ cord-010119-t1x9gknd 9387 15 or or CC cord-010119-t1x9gknd 9387 16 higher high JJR cord-010119-t1x9gknd 9387 17 ( ( -LRB- cord-010119-t1x9gknd 9387 18 1 1 CD cord-010119-t1x9gknd 9387 19 1 1 CD cord-010119-t1x9gknd 9387 20 Log Log NNP cord-010119-t1x9gknd 9387 21 ) ) -RRB- cord-010119-t1x9gknd 9387 22 than than IN cord-010119-t1x9gknd 9387 23 the the DT cord-010119-t1x9gknd 9387 24 colony colony NN cord-010119-t1x9gknd 9387 25 count count NN cord-010119-t1x9gknd 9387 26 of of IN cord-010119-t1x9gknd 9387 27 the the DT cord-010119-t1x9gknd 9387 28 seeded seed VBN cord-010119-t1x9gknd 9387 29 saline saline NN cord-010119-t1x9gknd 9387 30 after after IN cord-010119-t1x9gknd 9387 31 incubation incubation NN cord-010119-t1x9gknd 9387 32 . . . cord-010119-t1x9gknd 9388 1 Results/ Results/ . cord-010119-t1x9gknd 9389 1 Finding finding NN cord-010119-t1x9gknd 9389 2 : : : cord-010119-t1x9gknd 9390 1 The the DT cord-010119-t1x9gknd 9390 2 serially serially RB cord-010119-t1x9gknd 9390 3 diluted dilute VBN cord-010119-t1x9gknd 9390 4 strains strain NNS cord-010119-t1x9gknd 9390 5 and and CC cord-010119-t1x9gknd 9390 6 all all DT cord-010119-t1x9gknd 9390 7 BioBall BioBall NNP cord-010119-t1x9gknd 9390 8 TM TM NNP cord-010119-t1x9gknd 9390 9 strains strain NNS cord-010119-t1x9gknd 9390 10 except except IN cord-010119-t1x9gknd 9390 11 P. p. NN cord-010119-t1x9gknd 9390 12 aeruginosa aeruginosa NN cord-010119-t1x9gknd 9390 13 , , , cord-010119-t1x9gknd 9390 14 NCTC NCTC NNP cord-010119-t1x9gknd 9390 15 12924 12924 CD cord-010119-t1x9gknd 9390 16 , , , cord-010119-t1x9gknd 9390 17 were be VBD cord-010119-t1x9gknd 9390 18 determined determine VBN cord-010119-t1x9gknd 9390 19 to to TO cord-010119-t1x9gknd 9390 20 be be VB cord-010119-t1x9gknd 9390 21 plasma plasma NN cord-010119-t1x9gknd 9390 22 resistant resistant JJ cord-010119-t1x9gknd 9390 23 . . . cord-010119-t1x9gknd 9391 1 The the DT cord-010119-t1x9gknd 9391 2 BioBall BioBall NNP cord-010119-t1x9gknd 9391 3 TM TM NNP cord-010119-t1x9gknd 9391 4 P. P. NNP cord-010119-t1x9gknd 9391 5 aeruginosa aeruginosa NN cord-010119-t1x9gknd 9391 6 was be VBD cord-010119-t1x9gknd 9391 7 susceptible susceptible JJ cord-010119-t1x9gknd 9391 8 to to IN cord-010119-t1x9gknd 9391 9 the the DT cord-010119-t1x9gknd 9391 10 antimicrobial antimicrobial JJ cord-010119-t1x9gknd 9391 11 effects effect NNS cord-010119-t1x9gknd 9391 12 of of IN cord-010119-t1x9gknd 9391 13 human human JJ cord-010119-t1x9gknd 9391 14 plasma plasma NN cord-010119-t1x9gknd 9391 15 , , , cord-010119-t1x9gknd 9391 16 but but CC cord-010119-t1x9gknd 9391 17 when when WRB cord-010119-t1x9gknd 9391 18 spiked spike VBN cord-010119-t1x9gknd 9391 19 into into IN cord-010119-t1x9gknd 9391 20 4 4 CD cord-010119-t1x9gknd 9391 21 mL ml NN cord-010119-t1x9gknd 9391 22 of of IN cord-010119-t1x9gknd 9391 23 Leukocyte Leukocyte NNP cord-010119-t1x9gknd 9391 24 Reduced Reduced NNP cord-010119-t1x9gknd 9391 25 Apheresis Apheresis NNP cord-010119-t1x9gknd 9391 26 Platelets platelet NNS cord-010119-t1x9gknd 9391 27 ( ( -LRB- cord-010119-t1x9gknd 9391 28 LRAP LRAP NNP cord-010119-t1x9gknd 9391 29 ) ) -RRB- cord-010119-t1x9gknd 9391 30 and and CC cord-010119-t1x9gknd 9391 31 inoculated inoculate VBD cord-010119-t1x9gknd 9391 32 into into IN cord-010119-t1x9gknd 9391 33 BTA BTA NNP cord-010119-t1x9gknd 9391 34 BPA BPA NNP cord-010119-t1x9gknd 9391 35 bottles bottle NNS cord-010119-t1x9gknd 9391 36 and and CC cord-010119-t1x9gknd 9391 37 loaded load VBN cord-010119-t1x9gknd 9391 38 into into IN cord-010119-t1x9gknd 9391 39 the the DT cord-010119-t1x9gknd 9391 40 BTA BTA NNP cord-010119-t1x9gknd 9391 41 3D 3d NN cord-010119-t1x9gknd 9391 42 and and CC cord-010119-t1x9gknd 9391 43 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9391 44 the the DT cord-010119-t1x9gknd 9391 45 organism organism NN cord-010119-t1x9gknd 9391 46 was be VBD cord-010119-t1x9gknd 9391 47 recovered recover VBN cord-010119-t1x9gknd 9391 48 100 100 CD cord-010119-t1x9gknd 9391 49 % % NN cord-010119-t1x9gknd 9391 50 . . . cord-010119-t1x9gknd 9392 1 Conclusion conclusion NN cord-010119-t1x9gknd 9392 2 : : : cord-010119-t1x9gknd 9393 1 Results result NNS cord-010119-t1x9gknd 9393 2 confirm confirm VBP cord-010119-t1x9gknd 9393 3 that that IN cord-010119-t1x9gknd 9393 4 previously previously RB cord-010119-t1x9gknd 9393 5 tested test VBN cord-010119-t1x9gknd 9393 6 organisms organism NNS cord-010119-t1x9gknd 9393 7 and and CC cord-010119-t1x9gknd 9393 8 additional additional JJ cord-010119-t1x9gknd 9393 9 strains strain NNS cord-010119-t1x9gknd 9393 10 are be VBP cord-010119-t1x9gknd 9393 11 plasma plasma NN cord-010119-t1x9gknd 9393 12 resistant resistant JJ cord-010119-t1x9gknd 9393 13 with with IN cord-010119-t1x9gknd 9393 14 the the DT cord-010119-t1x9gknd 9393 15 exception exception NN cord-010119-t1x9gknd 9393 16 of of IN cord-010119-t1x9gknd 9393 17 P. P. NNP cord-010119-t1x9gknd 9393 18 aeruginosa aeruginosa NN cord-010119-t1x9gknd 9393 19 , , , cord-010119-t1x9gknd 9393 20 NCTC NCTC NNP cord-010119-t1x9gknd 9393 21 12924 12924 CD cord-010119-t1x9gknd 9393 22 . . . cord-010119-t1x9gknd 9394 1 However however RB cord-010119-t1x9gknd 9394 2 , , , cord-010119-t1x9gknd 9394 3 the the DT cord-010119-t1x9gknd 9394 4 BPA BPA NNP cord-010119-t1x9gknd 9394 5 bottles bottle NNS cord-010119-t1x9gknd 9394 6 still still RB cord-010119-t1x9gknd 9394 7 recover recover VBP cord-010119-t1x9gknd 9394 8 P. P. NNP cord-010119-t1x9gknd 9394 9 aeruginosa aeruginosa NN cord-010119-t1x9gknd 9394 10 in in IN cord-010119-t1x9gknd 9394 11 the the DT cord-010119-t1x9gknd 9394 12 presence presence NN cord-010119-t1x9gknd 9394 13 of of IN cord-010119-t1x9gknd 9394 14 LRAP LRAP NNP cord-010119-t1x9gknd 9394 15 . . . cord-010119-t1x9gknd 9395 1 BPA BPA NNP cord-010119-t1x9gknd 9395 2 / / SYM cord-010119-t1x9gknd 9395 3 BPN BPN NNP cord-010119-t1x9gknd 9395 4 bottles bottle NNS cord-010119-t1x9gknd 9395 5 inoculated inoculate VBN cord-010119-t1x9gknd 9395 6 with with IN cord-010119-t1x9gknd 9395 7 select select JJ cord-010119-t1x9gknd 9395 8 organisms organism NNS cord-010119-t1x9gknd 9395 9 from from IN cord-010119-t1x9gknd 9395 10 this this DT cord-010119-t1x9gknd 9395 11 panel panel NN cord-010119-t1x9gknd 9395 12 in in IN cord-010119-t1x9gknd 9395 13 the the DT cord-010119-t1x9gknd 9395 14 presence presence NN cord-010119-t1x9gknd 9395 15 of of IN cord-010119-t1x9gknd 9395 16 4mL 4ml CD cord-010119-t1x9gknd 9395 17 LRAP LRAP NNP cord-010119-t1x9gknd 9395 18 demonstrated demonstrate VBD cord-010119-t1x9gknd 9395 19 100 100 CD cord-010119-t1x9gknd 9395 20 % % NN cord-010119-t1x9gknd 9395 21 recovery recovery NN cord-010119-t1x9gknd 9395 22 when when WRB cord-010119-t1x9gknd 9395 23 loaded load VBN cord-010119-t1x9gknd 9395 24 onto onto IN cord-010119-t1x9gknd 9395 25 the the DT cord-010119-t1x9gknd 9395 26 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9395 27 and and CC cord-010119-t1x9gknd 9395 28 3D 3D NNP cord-010119-t1x9gknd 9395 29 ( ( -LRB- cord-010119-t1x9gknd 9395 30 Table Table NNP cord-010119-t1x9gknd 9395 31 1 1 CD cord-010119-t1x9gknd 9395 32 ) ) -RRB- cord-010119-t1x9gknd 9395 33 . . . cord-010119-t1x9gknd 9396 1 Further further JJ cord-010119-t1x9gknd 9396 2 studies study NNS cord-010119-t1x9gknd 9396 3 may may MD cord-010119-t1x9gknd 9396 4 be be VB cord-010119-t1x9gknd 9396 5 required require VBN cord-010119-t1x9gknd 9396 6 to to TO cord-010119-t1x9gknd 9396 7 determine determine VB cord-010119-t1x9gknd 9396 8 if if IN cord-010119-t1x9gknd 9396 9 higher high JJR cord-010119-t1x9gknd 9396 10 test test NN cord-010119-t1x9gknd 9396 11 volumes volume NNS cord-010119-t1x9gknd 9396 12 of of IN cord-010119-t1x9gknd 9396 13 LRAP LRAP NNP cord-010119-t1x9gknd 9396 14 could could MD cord-010119-t1x9gknd 9396 15 affect affect VB cord-010119-t1x9gknd 9396 16 the the DT cord-010119-t1x9gknd 9396 17 recovery recovery NN cord-010119-t1x9gknd 9396 18 of of IN cord-010119-t1x9gknd 9396 19 plasma plasma NN cord-010119-t1x9gknd 9396 20 sensitive sensitive JJ cord-010119-t1x9gknd 9396 21 strains strain NNS cord-010119-t1x9gknd 9396 22 . . . cord-010119-t1x9gknd 9397 1 * * NFP cord-010119-t1x9gknd 9397 2 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9397 3 is be VBZ cord-010119-t1x9gknd 9397 4 not not RB cord-010119-t1x9gknd 9397 5 FDA FDA NNP cord-010119-t1x9gknd 9397 6 cleared clear VBN cord-010119-t1x9gknd 9397 7 for for IN cord-010119-t1x9gknd 9397 8 platelet platelet NN cord-010119-t1x9gknd 9397 9 testing testing NN cord-010119-t1x9gknd 9397 10 A. a. NN cord-010119-t1x9gknd 9397 11 notoscriptus notoscriptus NN cord-010119-t1x9gknd 9397 12 , , , cord-010119-t1x9gknd 9397 13 identified identify VBN cord-010119-t1x9gknd 9397 14 as as IN cord-010119-t1x9gknd 9397 15 a a DT cord-010119-t1x9gknd 9397 16 major major JJ cord-010119-t1x9gknd 9397 17 urban urban JJ cord-010119-t1x9gknd 9397 18 vector vector NN cord-010119-t1x9gknd 9397 19 of of IN cord-010119-t1x9gknd 9397 20 RRV RRV NNP cord-010119-t1x9gknd 9397 21 , , , cord-010119-t1x9gknd 9397 22 is be VBZ cord-010119-t1x9gknd 9397 23 also also RB cord-010119-t1x9gknd 9397 24 capable capable JJ cord-010119-t1x9gknd 9397 25 of of IN cord-010119-t1x9gknd 9397 26 transmitting transmit VBG cord-010119-t1x9gknd 9397 27 Dengue dengue NN cord-010119-t1x9gknd 9397 28 virus virus NN cord-010119-t1x9gknd 9397 29 1 1 CD cord-010119-t1x9gknd 9397 30 - - SYM cord-010119-t1x9gknd 9397 31 4 4 CD cord-010119-t1x9gknd 9397 32 , , , cord-010119-t1x9gknd 9397 33 and and CC cord-010119-t1x9gknd 9397 34 has have VBZ cord-010119-t1x9gknd 9397 35 recently recently RB cord-010119-t1x9gknd 9397 36 been be VBN cord-010119-t1x9gknd 9397 37 found find VBN cord-010119-t1x9gknd 9397 38 in in IN cord-010119-t1x9gknd 9397 39 Los Los NNP cord-010119-t1x9gknd 9397 40 Angeles Angeles NNP cord-010119-t1x9gknd 9397 41 , , , cord-010119-t1x9gknd 9397 42 illustrating illustrate VBG cord-010119-t1x9gknd 9397 43 an an DT cord-010119-t1x9gknd 9397 44 expansion expansion NN cord-010119-t1x9gknd 9397 45 in in IN cord-010119-t1x9gknd 9397 46 range range NN cord-010119-t1x9gknd 9397 47 . . . cord-010119-t1x9gknd 9398 1 With with IN cord-010119-t1x9gknd 9398 2 the the DT cord-010119-t1x9gknd 9398 3 growing grow VBG cord-010119-t1x9gknd 9398 4 geographical geographical JJ cord-010119-t1x9gknd 9398 5 distribution distribution NN cord-010119-t1x9gknd 9398 6 of of IN cord-010119-t1x9gknd 9398 7 Aedes Aedes NNP cord-010119-t1x9gknd 9398 8 species specie VBZ cord-010119-t1x9gknd 9398 9 mosquitoes mosquito NNS cord-010119-t1x9gknd 9398 10 , , , cord-010119-t1x9gknd 9398 11 the the DT cord-010119-t1x9gknd 9398 12 potential potential NN cord-010119-t1x9gknd 9398 13 for for IN cord-010119-t1x9gknd 9398 14 RRV RRV NNP cord-010119-t1x9gknd 9398 15 to to TO cord-010119-t1x9gknd 9398 16 enter enter VB cord-010119-t1x9gknd 9398 17 local local JJ cord-010119-t1x9gknd 9398 18 transmission transmission NN cord-010119-t1x9gknd 9398 19 cycles cycle NNS cord-010119-t1x9gknd 9398 20 outside outside RB cord-010119-t1x9gknd 9398 21 of of IN cord-010119-t1x9gknd 9398 22 Australia Australia NNP cord-010119-t1x9gknd 9398 23 is be VBZ cord-010119-t1x9gknd 9398 24 significant significant JJ cord-010119-t1x9gknd 9398 25 . . . cord-010119-t1x9gknd 9399 1 In in IN cord-010119-t1x9gknd 9399 2 2014 2014 CD cord-010119-t1x9gknd 9399 3 , , , cord-010119-t1x9gknd 9399 4 a a DT cord-010119-t1x9gknd 9399 5 probable probable JJ cord-010119-t1x9gknd 9399 6 transfusiontransmission transfusiontransmission NN cord-010119-t1x9gknd 9399 7 ( ( -LRB- cord-010119-t1x9gknd 9399 8 TT TT NNP cord-010119-t1x9gknd 9399 9 ) ) -RRB- cord-010119-t1x9gknd 9399 10 was be VBD cord-010119-t1x9gknd 9399 11 confirmed confirm VBN cord-010119-t1x9gknd 9399 12 as as IN cord-010119-t1x9gknd 9399 13 the the DT cord-010119-t1x9gknd 9399 14 cause cause NN cord-010119-t1x9gknd 9399 15 for for IN cord-010119-t1x9gknd 9399 16 an an DT cord-010119-t1x9gknd 9399 17 RRV RRV NNP cord-010119-t1x9gknd 9399 18 infection infection NN cord-010119-t1x9gknd 9399 19 in in IN cord-010119-t1x9gknd 9399 20 Australia Australia NNP cord-010119-t1x9gknd 9399 21 , , , cord-010119-t1x9gknd 9399 22 validating validate VBG cord-010119-t1x9gknd 9399 23 the the DT cord-010119-t1x9gknd 9399 24 reality reality NN cord-010119-t1x9gknd 9399 25 that that WDT cord-010119-t1x9gknd 9399 26 RRV RRV NNP cord-010119-t1x9gknd 9399 27 TT TT NNP cord-010119-t1x9gknd 9399 28 can can MD cord-010119-t1x9gknd 9399 29 occur occur VB cord-010119-t1x9gknd 9399 30 . . . cord-010119-t1x9gknd 9400 1 RRV RRV NNP cord-010119-t1x9gknd 9400 2 morbidity morbidity NN cord-010119-t1x9gknd 9400 3 leads lead VBZ cord-010119-t1x9gknd 9400 4 to to IN cord-010119-t1x9gknd 9400 5 clinical clinical JJ cord-010119-t1x9gknd 9400 6 manifestations manifestation NNS cord-010119-t1x9gknd 9400 7 that that WDT cord-010119-t1x9gknd 9400 8 are be VBP cord-010119-t1x9gknd 9400 9 similar similar JJ cord-010119-t1x9gknd 9400 10 to to IN cord-010119-t1x9gknd 9400 11 CHIKV CHIKV NNP cord-010119-t1x9gknd 9400 12 infection infection NN cord-010119-t1x9gknd 9400 13 , , , cord-010119-t1x9gknd 9400 14 with with IN cord-010119-t1x9gknd 9400 15 varying vary VBG cord-010119-t1x9gknd 9400 16 degrees degree NNS cord-010119-t1x9gknd 9400 17 of of IN cord-010119-t1x9gknd 9400 18 arthralgia arthralgia NNP cord-010119-t1x9gknd 9400 19 , , , cord-010119-t1x9gknd 9400 20 which which WDT cord-010119-t1x9gknd 9400 21 can can MD cord-010119-t1x9gknd 9400 22 become become VB cord-010119-t1x9gknd 9400 23 debilitating debilitating JJ cord-010119-t1x9gknd 9400 24 . . . cord-010119-t1x9gknd 9401 1 Various various JJ cord-010119-t1x9gknd 9401 2 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 9401 3 to to IN cord-010119-t1x9gknd 9401 4 symptomatic symptomatic JJ cord-010119-t1x9gknd 9401 5 infection infection NN cord-010119-t1x9gknd 9401 6 ratios ratio NNS cord-010119-t1x9gknd 9401 7 have have VBP cord-010119-t1x9gknd 9401 8 been be VBN cord-010119-t1x9gknd 9401 9 reported report VBN cord-010119-t1x9gknd 9401 10 , , , cord-010119-t1x9gknd 9401 11 but but CC cord-010119-t1x9gknd 9401 12 this this DT cord-010119-t1x9gknd 9401 13 further further JJ cord-010119-t1x9gknd 9401 14 increases increase VBZ cord-010119-t1x9gknd 9401 15 the the DT cord-010119-t1x9gknd 9401 16 risk risk NN cord-010119-t1x9gknd 9401 17 of of IN cord-010119-t1x9gknd 9401 18 additional additional JJ cord-010119-t1x9gknd 9401 19 TT TT NNP cord-010119-t1x9gknd 9401 20 in in IN cord-010119-t1x9gknd 9401 21 endemic endemic JJ cord-010119-t1x9gknd 9401 22 areas area NNS cord-010119-t1x9gknd 9401 23 and and CC cord-010119-t1x9gknd 9401 24 could could MD cord-010119-t1x9gknd 9401 25 mask mask VB cord-010119-t1x9gknd 9401 26 the the DT cord-010119-t1x9gknd 9401 27 spread spread NN cord-010119-t1x9gknd 9401 28 of of IN cord-010119-t1x9gknd 9401 29 the the DT cord-010119-t1x9gknd 9401 30 disease disease NN cord-010119-t1x9gknd 9401 31 globally globally RB cord-010119-t1x9gknd 9401 32 . . . cord-010119-t1x9gknd 9402 1 Study Study NNP cord-010119-t1x9gknd 9402 2 Design Design NNP cord-010119-t1x9gknd 9402 3 / / SYM cord-010119-t1x9gknd 9402 4 Method method NN cord-010119-t1x9gknd 9402 5 : : : cord-010119-t1x9gknd 9402 6 Platelet platelet NN cord-010119-t1x9gknd 9402 7 concentrates concentrate NNS cord-010119-t1x9gknd 9402 8 ( ( -LRB- cord-010119-t1x9gknd 9402 9 PC pc NN cord-010119-t1x9gknd 9402 10 ) ) -RRB- cord-010119-t1x9gknd 9402 11 prepared prepare VBN cord-010119-t1x9gknd 9402 12 in in IN cord-010119-t1x9gknd 9402 13 PAS PAS NNP cord-010119-t1x9gknd 9402 14 were be VBD cord-010119-t1x9gknd 9402 15 inoculated inoculate VBN cord-010119-t1x9gknd 9402 16 with with IN cord-010119-t1x9gknd 9402 17 RRV RRV NNP cord-010119-t1x9gknd 9402 18 , , , cord-010119-t1x9gknd 9402 19 amotosalen amotosalen NNP cord-010119-t1x9gknd 9402 20 was be VBD cord-010119-t1x9gknd 9402 21 added add VBN cord-010119-t1x9gknd 9402 22 to to IN cord-010119-t1x9gknd 9402 23 final final JJ cord-010119-t1x9gknd 9402 24 concentration concentration NN cord-010119-t1x9gknd 9402 25 of of IN cord-010119-t1x9gknd 9402 26 150 150 CD cord-010119-t1x9gknd 9402 27 mM mm CD cord-010119-t1x9gknd 9402 28 and and CC cord-010119-t1x9gknd 9402 29 the the DT cord-010119-t1x9gknd 9402 30 units unit NNS cord-010119-t1x9gknd 9402 31 were be VBD cord-010119-t1x9gknd 9402 32 treated treat VBN cord-010119-t1x9gknd 9402 33 with with IN cord-010119-t1x9gknd 9402 34 UVA UVA NNP cord-010119-t1x9gknd 9402 35 light light NN cord-010119-t1x9gknd 9402 36 . . . cord-010119-t1x9gknd 9403 1 Pre pre JJ cord-010119-t1x9gknd 9403 2 - - JJ cord-010119-t1x9gknd 9403 3 and and CC cord-010119-t1x9gknd 9403 4 post post JJ cord-010119-t1x9gknd 9403 5 - - JJ cord-010119-t1x9gknd 9403 6 treatment treatment JJ cord-010119-t1x9gknd 9403 7 illumination illumination NN cord-010119-t1x9gknd 9403 8 samples sample NNS cord-010119-t1x9gknd 9403 9 were be VBD cord-010119-t1x9gknd 9403 10 collected collect VBN cord-010119-t1x9gknd 9403 11 for for IN cord-010119-t1x9gknd 9403 12 titration titration NN cord-010119-t1x9gknd 9403 13 . . . cord-010119-t1x9gknd 9404 1 AS-5 as-5 NN cord-010119-t1x9gknd 9405 1 RBC RBC NNP cord-010119-t1x9gknd 9405 2 units unit NNS cord-010119-t1x9gknd 9405 3 were be VBD cord-010119-t1x9gknd 9405 4 contaminated contaminate VBN cord-010119-t1x9gknd 9405 5 with with IN cord-010119-t1x9gknd 9405 6 RRV RRV NNP cord-010119-t1x9gknd 9405 7 , , , cord-010119-t1x9gknd 9405 8 mixed mix VBN cord-010119-t1x9gknd 9405 9 with with IN cord-010119-t1x9gknd 9405 10 processing processing NN cord-010119-t1x9gknd 9405 11 solution solution NN cord-010119-t1x9gknd 9405 12 / / SYM cord-010119-t1x9gknd 9405 13 glutathione glutathione NN cord-010119-t1x9gknd 9405 14 ( ( -LRB- cord-010119-t1x9gknd 9405 15 GSH GSH NNP cord-010119-t1x9gknd 9405 16 ) ) -RRB- cord-010119-t1x9gknd 9405 17 and and CC cord-010119-t1x9gknd 9405 18 treated treat VBN cord-010119-t1x9gknd 9405 19 with with IN cord-010119-t1x9gknd 9405 20 amustaline amustaline NN cord-010119-t1x9gknd 9405 21 at at IN cord-010119-t1x9gknd 9405 22 a a DT cord-010119-t1x9gknd 9405 23 final final JJ cord-010119-t1x9gknd 9405 24 200 200 CD cord-010119-t1x9gknd 9405 25 mM mm CD cord-010119-t1x9gknd 9405 26 concentration concentration NN cord-010119-t1x9gknd 9405 27 . . . cord-010119-t1x9gknd 9406 1 Pre pre JJ cord-010119-t1x9gknd 9406 2 - - JJ cord-010119-t1x9gknd 9406 3 and and CC cord-010119-t1x9gknd 9406 4 post post JJ cord-010119-t1x9gknd 9406 5 - - JJ cord-010119-t1x9gknd 9406 6 treatment treatment JJ cord-010119-t1x9gknd 9406 7 samples sample NNS cord-010119-t1x9gknd 9406 8 were be VBD cord-010119-t1x9gknd 9406 9 removed remove VBN cord-010119-t1x9gknd 9406 10 prior prior RB cord-010119-t1x9gknd 9406 11 to to IN cord-010119-t1x9gknd 9406 12 amustaline amustaline JJ cord-010119-t1x9gknd 9406 13 treatment treatment NN cord-010119-t1x9gknd 9406 14 and and CC cord-010119-t1x9gknd 9406 15 3hrs 3hrs CD cord-010119-t1x9gknd 9406 16 after after IN cord-010119-t1x9gknd 9406 17 amustaline amustaline NN cord-010119-t1x9gknd 9406 18 addition addition NN cord-010119-t1x9gknd 9406 19 , , , cord-010119-t1x9gknd 9406 20 respectively respectively RB cord-010119-t1x9gknd 9406 21 , , , cord-010119-t1x9gknd 9406 22 for for IN cord-010119-t1x9gknd 9406 23 titration titration NN cord-010119-t1x9gknd 9406 24 by by IN cord-010119-t1x9gknd 9406 25 plaque plaque NN cord-010119-t1x9gknd 9406 26 assay assay NN cord-010119-t1x9gknd 9406 27 on on IN cord-010119-t1x9gknd 9406 28 Vero76 Vero76 NNP cord-010119-t1x9gknd 9406 29 cells cell NNS cord-010119-t1x9gknd 9406 30 . . . cord-010119-t1x9gknd 9407 1 Log log JJ cord-010119-t1x9gknd 9407 2 reduction reduction NN cord-010119-t1x9gknd 9407 3 was be VBD cord-010119-t1x9gknd 9407 4 calculated calculate VBN cord-010119-t1x9gknd 9407 5 as as IN cord-010119-t1x9gknd 9407 6 the the DT cord-010119-t1x9gknd 9407 7 difference difference NN cord-010119-t1x9gknd 9407 8 between between IN cord-010119-t1x9gknd 9407 9 the the DT cord-010119-t1x9gknd 9407 10 mean mean JJ cord-010119-t1x9gknd 9407 11 infectious infectious JJ cord-010119-t1x9gknd 9407 12 titer titer NN cord-010119-t1x9gknd 9407 13 in in IN cord-010119-t1x9gknd 9407 14 pre pre NNP cord-010119-t1x9gknd 9407 15 - - NN cord-010119-t1x9gknd 9407 16 vs vs RP cord-010119-t1x9gknd 9407 17 . . . cord-010119-t1x9gknd 9408 1 post post JJ cord-010119-t1x9gknd 9408 2 - - JJ cord-010119-t1x9gknd 9408 3 treatment treatment JJ cord-010119-t1x9gknd 9408 4 samples sample NNS cord-010119-t1x9gknd 9408 5 . . . cord-010119-t1x9gknd 9409 1 Results/ Results/ . cord-010119-t1x9gknd 9410 1 Finding finding NN cord-010119-t1x9gknd 9410 2 : : : cord-010119-t1x9gknd 9411 1 Inactivation inactivation NN cord-010119-t1x9gknd 9411 2 of of IN cord-010119-t1x9gknd 9411 3 RRV RRV NNP cord-010119-t1x9gknd 9411 4 was be VBD cord-010119-t1x9gknd 9411 5 achieved achieve VBN cord-010119-t1x9gknd 9411 6 to to IN cord-010119-t1x9gknd 9411 7 the the DT cord-010119-t1x9gknd 9411 8 limit limit NN cord-010119-t1x9gknd 9411 9 of of IN cord-010119-t1x9gknd 9411 10 detection detection NN cord-010119-t1x9gknd 9411 11 in in IN cord-010119-t1x9gknd 9411 12 PC PC NNP cord-010119-t1x9gknd 9411 13 and and CC cord-010119-t1x9gknd 9411 14 RBC RBC NNP cord-010119-t1x9gknd 9411 15 . . . cord-010119-t1x9gknd 9412 1 In in IN cord-010119-t1x9gknd 9412 2 PC pc NN cord-010119-t1x9gknd 9412 3 , , , cord-010119-t1x9gknd 9412 4 > > XX cord-010119-t1x9gknd 9412 5 5.1 5.1 CD cord-010119-t1x9gknd 9412 6 log log NN cord-010119-t1x9gknd 9412 7 10 10 CD cord-010119-t1x9gknd 9412 8 or or CC cord-010119-t1x9gknd 9412 9 log log VB cord-010119-t1x9gknd 9412 10 10 10 CD cord-010119-t1x9gknd 9412 11 /mL /mL : cord-010119-t1x9gknd 9412 12 of of IN cord-010119-t1x9gknd 9412 13 RRV RRV NNP cord-010119-t1x9gknd 9412 14 was be VBD cord-010119-t1x9gknd 9412 15 achieved achieve VBN cord-010119-t1x9gknd 9412 16 , , , cord-010119-t1x9gknd 9412 17 with with IN cord-010119-t1x9gknd 9412 18 > > XX cord-010119-t1x9gknd 9412 19 5.5 5.5 CD cord-010119-t1x9gknd 9412 20 log log NN cord-010119-t1x9gknd 9412 21 10 10 CD cord-010119-t1x9gknd 9412 22 or or CC cord-010119-t1x9gknd 9412 23 > > XX cord-010119-t1x9gknd 9413 1 5.2 5.2 CD cord-010119-t1x9gknd 9413 2 log log NN cord-010119-t1x9gknd 9413 3 10 10 CD cord-010119-t1x9gknd 9413 4 /mL /mL : cord-010119-t1x9gknd 9413 5 of of IN cord-010119-t1x9gknd 9413 6 RRV RRV NNP cord-010119-t1x9gknd 9413 7 inactivated inactivate VBD cord-010119-t1x9gknd 9413 8 in in IN cord-010119-t1x9gknd 9413 9 RBC RBC NNP cord-010119-t1x9gknd 9413 10 . . . cord-010119-t1x9gknd 9414 1 Conclusion conclusion NN cord-010119-t1x9gknd 9414 2 : : : cord-010119-t1x9gknd 9415 1 These these DT cord-010119-t1x9gknd 9415 2 studies study NNS cord-010119-t1x9gknd 9415 3 illustrate illustrate VBP cord-010119-t1x9gknd 9415 4 that that IN cord-010119-t1x9gknd 9415 5 amotosalen amotosalen NN cord-010119-t1x9gknd 9415 6 / / SYM cord-010119-t1x9gknd 9415 7 UVA UVA NNP cord-010119-t1x9gknd 9415 8 and and CC cord-010119-t1x9gknd 9415 9 amustaline/ amustaline/ CD cord-010119-t1x9gknd 9415 10 GSH GSH NNP cord-010119-t1x9gknd 9415 11 treatments treatment NNS cord-010119-t1x9gknd 9415 12 are be VBP cord-010119-t1x9gknd 9415 13 effective effective JJ cord-010119-t1x9gknd 9415 14 at at IN cord-010119-t1x9gknd 9415 15 inactivating inactivate VBG cord-010119-t1x9gknd 9415 16 RRV RRV NNP cord-010119-t1x9gknd 9415 17 in in IN cord-010119-t1x9gknd 9415 18 PC PC NNP cord-010119-t1x9gknd 9415 19 and and CC cord-010119-t1x9gknd 9415 20 RBC RBC NNP cord-010119-t1x9gknd 9415 21 , , , cord-010119-t1x9gknd 9415 22 respectively respectively RB cord-010119-t1x9gknd 9415 23 . . . cord-010119-t1x9gknd 9416 1 These these DT cord-010119-t1x9gknd 9416 2 data datum NNS cord-010119-t1x9gknd 9416 3 corroborate corroborate VBP cord-010119-t1x9gknd 9416 4 previous previous JJ cord-010119-t1x9gknd 9416 5 results result NNS cord-010119-t1x9gknd 9416 6 achieved achieve VBN cord-010119-t1x9gknd 9416 7 with with IN cord-010119-t1x9gknd 9416 8 other other JJ cord-010119-t1x9gknd 9416 9 alphaviruses alphavirus NNS cord-010119-t1x9gknd 9416 10 , , , cord-010119-t1x9gknd 9416 11 including include VBG cord-010119-t1x9gknd 9416 12 CHIKV CHIKV NNP cord-010119-t1x9gknd 9416 13 and and CC cord-010119-t1x9gknd 9416 14 Mayaro Mayaro NNP cord-010119-t1x9gknd 9416 15 virus virus NN cord-010119-t1x9gknd 9416 16 which which WDT cord-010119-t1x9gknd 9416 17 are be VBP cord-010119-t1x9gknd 9416 18 inactivated inactivate VBN cord-010119-t1x9gknd 9416 19 at at IN cord-010119-t1x9gknd 9416 20 high high JJ cord-010119-t1x9gknd 9416 21 titers titer NNS cord-010119-t1x9gknd 9416 22 in in IN cord-010119-t1x9gknd 9416 23 PC PC NNP cord-010119-t1x9gknd 9416 24 and and CC cord-010119-t1x9gknd 9416 25 RBC RBC NNP cord-010119-t1x9gknd 9416 26 , , , cord-010119-t1x9gknd 9416 27 demonstrating demonstrate VBG cord-010119-t1x9gknd 9416 28 the the DT cord-010119-t1x9gknd 9416 29 ability ability NN cord-010119-t1x9gknd 9416 30 for for IN cord-010119-t1x9gknd 9416 31 these these DT cord-010119-t1x9gknd 9416 32 systems system NNS cord-010119-t1x9gknd 9416 33 to to TO cord-010119-t1x9gknd 9416 34 mitigate mitigate VB cord-010119-t1x9gknd 9416 35 TT TT NNP cord-010119-t1x9gknd 9416 36 potential potential NN cord-010119-t1x9gknd 9416 37 and and CC cord-010119-t1x9gknd 9416 38 maintain maintain VB cord-010119-t1x9gknd 9416 39 safe safe JJ cord-010119-t1x9gknd 9416 40 blood blood NN cord-010119-t1x9gknd 9416 41 component component NN cord-010119-t1x9gknd 9416 42 availability availability NN cord-010119-t1x9gknd 9416 43 in in IN cord-010119-t1x9gknd 9416 44 endemic endemic JJ cord-010119-t1x9gknd 9416 45 areas area NNS cord-010119-t1x9gknd 9416 46 . . . cord-010119-t1x9gknd 9417 1 ( ( -LRB- cord-010119-t1x9gknd 9417 2 Data datum NNS cord-010119-t1x9gknd 9417 3 have have VBP cord-010119-t1x9gknd 9417 4 not not RB cord-010119-t1x9gknd 9417 5 been be VBN cord-010119-t1x9gknd 9417 6 submitted submit VBN cord-010119-t1x9gknd 9417 7 for for IN cord-010119-t1x9gknd 9417 8 FDA FDA NNP cord-010119-t1x9gknd 9417 9 review review NN cord-010119-t1x9gknd 9417 10 and and CC cord-010119-t1x9gknd 9417 11 INTERCEPT intercept VB cord-010119-t1x9gknd 9417 12 for for IN cord-010119-t1x9gknd 9417 13 red red JJ cord-010119-t1x9gknd 9417 14 blood blood NN cord-010119-t1x9gknd 9417 15 cell cell NN cord-010119-t1x9gknd 9417 16 is be VBZ cord-010119-t1x9gknd 9417 17 not not RB cord-010119-t1x9gknd 9417 18 approved approve VBN cord-010119-t1x9gknd 9417 19 for for IN cord-010119-t1x9gknd 9417 20 commercial commercial JJ cord-010119-t1x9gknd 9417 21 use use NN cord-010119-t1x9gknd 9417 22 ) ) -RRB- cord-010119-t1x9gknd 9417 23 . . . cord-010119-t1x9gknd 9418 1 Background Background NNP cord-010119-t1x9gknd 9418 2 / / SYM cord-010119-t1x9gknd 9418 3 Case Case NNP cord-010119-t1x9gknd 9418 4 Studies Studies NNPS cord-010119-t1x9gknd 9418 5 : : : cord-010119-t1x9gknd 9419 1 The the DT cord-010119-t1x9gknd 9419 2 INTERCEPTV INTERCEPTV NNP cord-010119-t1x9gknd 9419 3 R r NN cord-010119-t1x9gknd 9419 4 Blood blood NN cord-010119-t1x9gknd 9419 5 System system NN cord-010119-t1x9gknd 9419 6 for for IN cord-010119-t1x9gknd 9419 7 platelets platelet NNS cord-010119-t1x9gknd 9419 8 is be VBZ cord-010119-t1x9gknd 9419 9 designed design VBN cord-010119-t1x9gknd 9419 10 to to TO cord-010119-t1x9gknd 9419 11 inactivate inactivate VB cord-010119-t1x9gknd 9419 12 pathogens pathogen NNS cord-010119-t1x9gknd 9419 13 and and CC cord-010119-t1x9gknd 9419 14 contaminating contaminate VBG cord-010119-t1x9gknd 9419 15 leukocytes leukocyte NNS cord-010119-t1x9gknd 9419 16 . . . cord-010119-t1x9gknd 9420 1 This this DT cord-010119-t1x9gknd 9420 2 photochemical photochemical JJ cord-010119-t1x9gknd 9420 3 treatment treatment NN cord-010119-t1x9gknd 9420 4 process process NN cord-010119-t1x9gknd 9420 5 utilizes utilize VBZ cord-010119-t1x9gknd 9420 6 amotosalen amotosalen VBN cord-010119-t1x9gknd 9420 7 and and CC cord-010119-t1x9gknd 9420 8 low low JJ cord-010119-t1x9gknd 9420 9 energy energy NN cord-010119-t1x9gknd 9421 1 ultraviolet ultraviolet JJ cord-010119-t1x9gknd 9421 2 A a DT cord-010119-t1x9gknd 9421 3 ( ( -LRB- cord-010119-t1x9gknd 9421 4 UVA UVA NNP cord-010119-t1x9gknd 9421 5 ) ) -RRB- cord-010119-t1x9gknd 9421 6 light light NN cord-010119-t1x9gknd 9421 7 . . . cord-010119-t1x9gknd 9422 1 The the DT cord-010119-t1x9gknd 9422 2 current current JJ cord-010119-t1x9gknd 9422 3 available available JJ cord-010119-t1x9gknd 9422 4 sets set NNS cord-010119-t1x9gknd 9422 5 include include VBP cord-010119-t1x9gknd 9422 6 Small small JJ cord-010119-t1x9gknd 9422 7 volume volume NN cord-010119-t1x9gknd 9422 8 ( ( -LRB- cord-010119-t1x9gknd 9422 9 SV sv NN cord-010119-t1x9gknd 9422 10 ; ; : cord-010119-t1x9gknd 9422 11 255 255 CD cord-010119-t1x9gknd 9422 12 - - SYM cord-010119-t1x9gknd 9422 13 325 325 CD cord-010119-t1x9gknd 9422 14 mL ml NN cord-010119-t1x9gknd 9422 15 ) ) -RRB- cord-010119-t1x9gknd 9422 16 , , , cord-010119-t1x9gknd 9422 17 Large large JJ cord-010119-t1x9gknd 9422 18 Volume volume NN cord-010119-t1x9gknd 9422 19 ( ( -LRB- cord-010119-t1x9gknd 9422 20 LV LV NNP cord-010119-t1x9gknd 9422 21 ; ; : cord-010119-t1x9gknd 9422 22 300 300 CD cord-010119-t1x9gknd 9422 23 - - SYM cord-010119-t1x9gknd 9422 24 390 390 CD cord-010119-t1x9gknd 9422 25 mL ml NN cord-010119-t1x9gknd 9422 26 ) ) -RRB- cord-010119-t1x9gknd 9422 27 and and CC cord-010119-t1x9gknd 9422 28 Dual Dual NNP cord-010119-t1x9gknd 9422 29 Storage Storage NNP cord-010119-t1x9gknd 9422 30 containers container NNS cord-010119-t1x9gknd 9422 31 ( ( -LRB- cord-010119-t1x9gknd 9422 32 DS DS NNP cord-010119-t1x9gknd 9422 33 ; ; : cord-010119-t1x9gknd 9422 34 300 300 CD cord-010119-t1x9gknd 9422 35 - - SYM cord-010119-t1x9gknd 9422 36 420 420 CD cord-010119-t1x9gknd 9422 37 mL ml NN cord-010119-t1x9gknd 9422 38 ) ) -RRB- cord-010119-t1x9gknd 9422 39 designed design VBN cord-010119-t1x9gknd 9422 40 to to TO cord-010119-t1x9gknd 9422 41 treat treat VB cord-010119-t1x9gknd 9422 42 platelet platelet NN cord-010119-t1x9gknd 9422 43 doses dose NNS cord-010119-t1x9gknd 9422 44 between between IN cord-010119-t1x9gknd 9422 45 2.9 2.9 CD cord-010119-t1x9gknd 9422 46 and and CC cord-010119-t1x9gknd 9422 47 8.0x10 8.0x10 CD cord-010119-t1x9gknd 9422 48 11 11 CD cord-010119-t1x9gknd 9422 49 . . . cord-010119-t1x9gknd 9423 1 The the DT cord-010119-t1x9gknd 9423 2 new new JJ cord-010119-t1x9gknd 9423 3 Triple Triple NNP cord-010119-t1x9gknd 9423 4 Storage Storage NNP cord-010119-t1x9gknd 9423 5 ( ( -LRB- cord-010119-t1x9gknd 9423 6 TS TS NNP cord-010119-t1x9gknd 9423 7 ) ) -RRB- cord-010119-t1x9gknd 9423 8 set set NN cord-010119-t1x9gknd 9423 9 was be VBD cord-010119-t1x9gknd 9423 10 designed design VBN cord-010119-t1x9gknd 9423 11 to to TO cord-010119-t1x9gknd 9423 12 expand expand VB cord-010119-t1x9gknd 9423 13 the the DT cord-010119-t1x9gknd 9423 14 dose dose JJ cord-010119-t1x9gknd 9423 15 range range NN cord-010119-t1x9gknd 9423 16 to to IN cord-010119-t1x9gknd 9423 17 12.0x10 12.0x10 CD cord-010119-t1x9gknd 9423 18 11 11 CD cord-010119-t1x9gknd 9423 19 and and CC cord-010119-t1x9gknd 9423 20 the the DT cord-010119-t1x9gknd 9423 21 maximum maximum JJ cord-010119-t1x9gknd 9423 22 volume volume NN cord-010119-t1x9gknd 9423 23 to to IN cord-010119-t1x9gknd 9423 24 650 650 CD cord-010119-t1x9gknd 9423 25 mL ml NN cord-010119-t1x9gknd 9423 26 , , , cord-010119-t1x9gknd 9423 27 generating generate VBG cord-010119-t1x9gknd 9423 28 either either CC cord-010119-t1x9gknd 9423 29 2 2 CD cord-010119-t1x9gknd 9423 30 or or CC cord-010119-t1x9gknd 9423 31 3 3 CD cord-010119-t1x9gknd 9423 32 doses dose NNS cord-010119-t1x9gknd 9423 33 of of IN cord-010119-t1x9gknd 9423 34 pathogen pathogen NN cord-010119-t1x9gknd 9423 35 reduced reduce VBN cord-010119-t1x9gknd 9423 36 platelet platelet NN cord-010119-t1x9gknd 9423 37 components component NNS cord-010119-t1x9gknd 9423 38 ( ( -LRB- cord-010119-t1x9gknd 9423 39 PC pc NN cord-010119-t1x9gknd 9423 40 ) ) -RRB- cord-010119-t1x9gknd 9423 41 . . . cord-010119-t1x9gknd 9424 1 The the DT cord-010119-t1x9gknd 9424 2 objective objective NN cord-010119-t1x9gknd 9424 3 of of IN cord-010119-t1x9gknd 9424 4 this this DT cord-010119-t1x9gknd 9424 5 study study NN cord-010119-t1x9gknd 9424 6 was be VBD cord-010119-t1x9gknd 9424 7 to to TO cord-010119-t1x9gknd 9424 8 evaluate evaluate VB cord-010119-t1x9gknd 9424 9 the the DT cord-010119-t1x9gknd 9424 10 effectiveness effectiveness NN cord-010119-t1x9gknd 9424 11 of of IN cord-010119-t1x9gknd 9424 12 the the DT cord-010119-t1x9gknd 9424 13 system system NN cord-010119-t1x9gknd 9424 14 by by IN cord-010119-t1x9gknd 9424 15 performing perform VBG cord-010119-t1x9gknd 9424 16 log log NN cord-010119-t1x9gknd 9424 17 reduction reduction NN cord-010119-t1x9gknd 9424 18 assays assay NNS cord-010119-t1x9gknd 9424 19 using use VBG cord-010119-t1x9gknd 9424 20 representative representative JJ cord-010119-t1x9gknd 9424 21 gram gram NN cord-010119-t1x9gknd 9424 22 positive positive JJ cord-010119-t1x9gknd 9424 23 and and CC cord-010119-t1x9gknd 9424 24 negative negative JJ cord-010119-t1x9gknd 9424 25 bacteria bacteria NNS cord-010119-t1x9gknd 9424 26 and and CC cord-010119-t1x9gknd 9424 27 enveloped envelop VBN cord-010119-t1x9gknd 9424 28 and and CC cord-010119-t1x9gknd 9424 29 non non JJ cord-010119-t1x9gknd 9424 30 - - JJ cord-010119-t1x9gknd 9424 31 enveloped enveloped JJ cord-010119-t1x9gknd 9424 32 viruses virus NNS cord-010119-t1x9gknd 9424 33 in in IN cord-010119-t1x9gknd 9424 34 platelets platelet NNS cord-010119-t1x9gknd 9424 35 suspended suspend VBN cord-010119-t1x9gknd 9424 36 in in IN cord-010119-t1x9gknd 9424 37 PAS pas NN cord-010119-t1x9gknd 9424 38 , , , cord-010119-t1x9gknd 9424 39 or or CC cord-010119-t1x9gknd 9424 40 100 100 CD cord-010119-t1x9gknd 9424 41 % % NN cord-010119-t1x9gknd 9424 42 plasma plasma NN cord-010119-t1x9gknd 9424 43 using use VBG cord-010119-t1x9gknd 9424 44 TS TS NNP cord-010119-t1x9gknd 9424 45 Set Set NNP cord-010119-t1x9gknd 9424 46 . . . cord-010119-t1x9gknd 9425 1 Study Study NNP cord-010119-t1x9gknd 9425 2 Design Design NNP cord-010119-t1x9gknd 9425 3 / / SYM cord-010119-t1x9gknd 9425 4 Methods method NNS cord-010119-t1x9gknd 9425 5 : : : cord-010119-t1x9gknd 9425 6 For for IN cord-010119-t1x9gknd 9425 7 each each DT cord-010119-t1x9gknd 9425 8 experiment experiment NN cord-010119-t1x9gknd 9425 9 , , , cord-010119-t1x9gknd 9425 10 a a DT cord-010119-t1x9gknd 9425 11 platelet platelet NN cord-010119-t1x9gknd 9425 12 pool pool NN cord-010119-t1x9gknd 9425 13 was be VBD cord-010119-t1x9gknd 9425 14 prepared prepare VBN cord-010119-t1x9gknd 9425 15 either either CC cord-010119-t1x9gknd 9425 16 in in IN cord-010119-t1x9gknd 9425 17 47 47 CD cord-010119-t1x9gknd 9425 18 % % NN cord-010119-t1x9gknd 9425 19 plasma/53 plasma/53 NNP cord-010119-t1x9gknd 9425 20 % % NN cord-010119-t1x9gknd 9425 21 PAS pas NN cord-010119-t1x9gknd 9425 22 or or CC cord-010119-t1x9gknd 9425 23 100 100 CD cord-010119-t1x9gknd 9425 24 % % NN cord-010119-t1x9gknd 9425 25 plasma plasma NN cord-010119-t1x9gknd 9425 26 with with IN cord-010119-t1x9gknd 9425 27 a a DT cord-010119-t1x9gknd 9425 28 final final JJ cord-010119-t1x9gknd 9425 29 volume volume NN cord-010119-t1x9gknd 9425 30 of of IN cord-010119-t1x9gknd 9425 31 $ $ $ cord-010119-t1x9gknd 9425 32 650 650 CD cord-010119-t1x9gknd 9425 33 mL ml NN cord-010119-t1x9gknd 9425 34 and and CC cord-010119-t1x9gknd 9425 35 a a DT cord-010119-t1x9gknd 9425 36 dose dose NN cord-010119-t1x9gknd 9425 37 of of IN cord-010119-t1x9gknd 9425 38 9 9 CD cord-010119-t1x9gknd 9425 39 - - SYM cord-010119-t1x9gknd 9425 40 12 12 CD cord-010119-t1x9gknd 9425 41 3 3 CD cord-010119-t1x9gknd 9425 42 10 10 CD cord-010119-t1x9gknd 9425 43 11 11 CD cord-010119-t1x9gknd 9425 44 platelets platelet NNS cord-010119-t1x9gknd 9425 45 . . . cord-010119-t1x9gknd 9426 1 These these DT cord-010119-t1x9gknd 9426 2 conditions condition NNS cord-010119-t1x9gknd 9426 3 represent represent VBP cord-010119-t1x9gknd 9426 4 inactivation inactivation NN cord-010119-t1x9gknd 9426 5 using use VBG cord-010119-t1x9gknd 9426 6 the the DT cord-010119-t1x9gknd 9426 7 lowest low JJS cord-010119-t1x9gknd 9426 8 amotosalen amotosalen VBN cord-010119-t1x9gknd 9426 9 concentration concentration NN cord-010119-t1x9gknd 9426 10 ( ( -LRB- cord-010119-t1x9gknd 9426 11 135 135 CD cord-010119-t1x9gknd 9426 12 mM mm CD cord-010119-t1x9gknd 9426 13 ) ) -RRB- cord-010119-t1x9gknd 9426 14 and and CC cord-010119-t1x9gknd 9426 15 highest high JJS cord-010119-t1x9gknd 9426 16 concentration concentration NN cord-010119-t1x9gknd 9426 17 of of IN cord-010119-t1x9gknd 9426 18 platelets platelet NNS cord-010119-t1x9gknd 9426 19 . . . cord-010119-t1x9gknd 9427 1 Platelet platelet NN cord-010119-t1x9gknd 9427 2 units unit NNS cord-010119-t1x9gknd 9427 3 were be VBD cord-010119-t1x9gknd 9427 4 inoculated inoculate VBN cord-010119-t1x9gknd 9427 5 with with IN cord-010119-t1x9gknd 9427 6 high high JJ cord-010119-t1x9gknd 9427 7 titers titer NNS cord-010119-t1x9gknd 9427 8 of of IN cord-010119-t1x9gknd 9427 9 viruses virus NNS cord-010119-t1x9gknd 9427 10 , , , cord-010119-t1x9gknd 9427 11 or or CC cord-010119-t1x9gknd 9427 12 bacteria bacteria NNS cord-010119-t1x9gknd 9427 13 and and CC cord-010119-t1x9gknd 9427 14 treated treat VBN cord-010119-t1x9gknd 9427 15 . . . cord-010119-t1x9gknd 9428 1 Control Control NNP cord-010119-t1x9gknd 9428 2 ( ( -LRB- cord-010119-t1x9gknd 9428 3 Pre Pre NNP cord-010119-t1x9gknd 9428 4 - - NNP cord-010119-t1x9gknd 9428 5 UVA UVA NNP cord-010119-t1x9gknd 9428 6 ) ) -RRB- cord-010119-t1x9gknd 9428 7 and and CC cord-010119-t1x9gknd 9428 8 Test test NN cord-010119-t1x9gknd 9429 1 ( ( -LRB- cord-010119-t1x9gknd 9429 2 Post Post NNP cord-010119-t1x9gknd 9429 3 - - NNP cord-010119-t1x9gknd 9429 4 UVA UVA NNP cord-010119-t1x9gknd 9429 5 ) ) -RRB- cord-010119-t1x9gknd 9429 6 samples sample NNS cord-010119-t1x9gknd 9429 7 were be VBD cord-010119-t1x9gknd 9429 8 serially serially RB cord-010119-t1x9gknd 9429 9 diluted dilute VBN cord-010119-t1x9gknd 9429 10 and and CC cord-010119-t1x9gknd 9429 11 cultured cultured JJ cord-010119-t1x9gknd 9429 12 . . . cord-010119-t1x9gknd 9430 1 Plates plate NNS cord-010119-t1x9gknd 9430 2 with with IN cord-010119-t1x9gknd 9430 3 suitable suitable JJ cord-010119-t1x9gknd 9430 4 media medium NNS cord-010119-t1x9gknd 9430 5 were be VBD cord-010119-t1x9gknd 9430 6 used use VBN cord-010119-t1x9gknd 9430 7 for for IN cord-010119-t1x9gknd 9430 8 bacteria bacteria NNS cord-010119-t1x9gknd 9430 9 , , , cord-010119-t1x9gknd 9430 10 whereas whereas IN cord-010119-t1x9gknd 9430 11 viral viral JJ cord-010119-t1x9gknd 9430 12 titers titer NNS cord-010119-t1x9gknd 9430 13 were be VBD cord-010119-t1x9gknd 9430 14 determined determine VBN cord-010119-t1x9gknd 9430 15 using use VBG cord-010119-t1x9gknd 9430 16 plaque plaque NN cord-010119-t1x9gknd 9430 17 assays assay NNS cord-010119-t1x9gknd 9430 18 . . . cord-010119-t1x9gknd 9431 1 Log log JJ cord-010119-t1x9gknd 9431 2 reduction reduction NN cord-010119-t1x9gknd 9431 3 was be VBD cord-010119-t1x9gknd 9431 4 calculated calculate VBN cord-010119-t1x9gknd 9431 5 as as IN cord-010119-t1x9gknd 9431 6 the the DT cord-010119-t1x9gknd 9431 7 difference difference NN cord-010119-t1x9gknd 9431 8 between between IN cord-010119-t1x9gknd 9431 9 the the DT cord-010119-t1x9gknd 9431 10 log log NN cord-010119-t1x9gknd 9431 11 10 10 CD cord-010119-t1x9gknd 9431 12 titers titer NNS cord-010119-t1x9gknd 9431 13 in in IN cord-010119-t1x9gknd 9431 14 Control Control NNP cord-010119-t1x9gknd 9431 15 ( ( -LRB- cord-010119-t1x9gknd 9431 16 pre pre JJ cord-010119-t1x9gknd 9431 17 - - JJ cord-010119-t1x9gknd 9431 18 UVA UVA NNP cord-010119-t1x9gknd 9431 19 ) ) -RRB- cord-010119-t1x9gknd 9431 20 and and CC cord-010119-t1x9gknd 9431 21 Test Test NNP cord-010119-t1x9gknd 9431 22 ( ( -LRB- cord-010119-t1x9gknd 9431 23 post post JJ cord-010119-t1x9gknd 9431 24 - - JJ cord-010119-t1x9gknd 9431 25 UVA UVA NNP cord-010119-t1x9gknd 9431 26 ) ) -RRB- cord-010119-t1x9gknd 9431 27 samples sample NNS cord-010119-t1x9gknd 9431 28 . . . cord-010119-t1x9gknd 9432 1 Conclusion Conclusion NNP cord-010119-t1x9gknd 9432 2 Dromedary Dromedary NNP cord-010119-t1x9gknd 9432 3 camels camel NNS cord-010119-t1x9gknd 9432 4 were be VBD cord-010119-t1x9gknd 9432 5 identified identify VBN cord-010119-t1x9gknd 9432 6 to to TO cord-010119-t1x9gknd 9432 7 be be VB cord-010119-t1x9gknd 9432 8 the the DT cord-010119-t1x9gknd 9432 9 reservoir reservoir NN cord-010119-t1x9gknd 9432 10 of of IN cord-010119-t1x9gknd 9432 11 MERS MERS NNP cord-010119-t1x9gknd 9432 12 CoV CoV NNP cord-010119-t1x9gknd 9432 13 , , , cord-010119-t1x9gknd 9432 14 transmission transmission NN cord-010119-t1x9gknd 9432 15 to to IN cord-010119-t1x9gknd 9432 16 humans human NNS cord-010119-t1x9gknd 9432 17 occurs occur VBZ cord-010119-t1x9gknd 9432 18 through through IN cord-010119-t1x9gknd 9432 19 direct direct JJ cord-010119-t1x9gknd 9432 20 and and CC cord-010119-t1x9gknd 9432 21 indirect indirect JJ cord-010119-t1x9gknd 9432 22 contact contact NN cord-010119-t1x9gknd 9432 23 . . . cord-010119-t1x9gknd 9433 1 MERS MERS NNP cord-010119-t1x9gknd 9433 2 CoV CoV NNP cord-010119-t1x9gknd 9433 3 has have VBZ cord-010119-t1x9gknd 9433 4 been be VBN cord-010119-t1x9gknd 9433 5 detected detect VBN cord-010119-t1x9gknd 9433 6 with with IN cord-010119-t1x9gknd 9433 7 high high JJ cord-010119-t1x9gknd 9433 8 genomic genomic JJ cord-010119-t1x9gknd 9433 9 titers titer NNS cord-010119-t1x9gknd 9433 10 of of IN cord-010119-t1x9gknd 9433 11 6 6 CD cord-010119-t1x9gknd 9433 12 - - SYM cord-010119-t1x9gknd 9433 13 10 10 CD cord-010119-t1x9gknd 9433 14 logs log NNS cord-010119-t1x9gknd 9433 15 in in IN cord-010119-t1x9gknd 9433 16 respiratory respiratory JJ cord-010119-t1x9gknd 9433 17 secretions secretion NNS cord-010119-t1x9gknd 9433 18 of of IN cord-010119-t1x9gknd 9433 19 MERS MERS NNP cord-010119-t1x9gknd 9433 20 patients patient NNS cord-010119-t1x9gknd 9433 21 , , , cord-010119-t1x9gknd 9433 22 and and CC cord-010119-t1x9gknd 9433 23 with with IN cord-010119-t1x9gknd 9433 24 lower low JJR cord-010119-t1x9gknd 9433 25 genomic genomic JJ cord-010119-t1x9gknd 9433 26 titers titer NNS cord-010119-t1x9gknd 9433 27 of of IN cord-010119-t1x9gknd 9433 28 4 4 CD cord-010119-t1x9gknd 9433 29 - - SYM cord-010119-t1x9gknd 9433 30 5 5 CD cord-010119-t1x9gknd 9433 31 logs log NNS cord-010119-t1x9gknd 9433 32 in in IN cord-010119-t1x9gknd 9433 33 blood blood NN cord-010119-t1x9gknd 9433 34 . . . cord-010119-t1x9gknd 9434 1 The the DT cord-010119-t1x9gknd 9434 2 presence presence NN cord-010119-t1x9gknd 9434 3 viral viral JJ cord-010119-t1x9gknd 9434 4 particles particle NNS cord-010119-t1x9gknd 9434 5 in in IN cord-010119-t1x9gknd 9434 6 the the DT cord-010119-t1x9gknd 9434 7 blood blood NN cord-010119-t1x9gknd 9434 8 of of IN cord-010119-t1x9gknd 9434 9 acute acute JJ cord-010119-t1x9gknd 9434 10 patients patient NNS cord-010119-t1x9gknd 9434 11 gives give VBZ cord-010119-t1x9gknd 9434 12 rise rise NN cord-010119-t1x9gknd 9434 13 to to IN cord-010119-t1x9gknd 9434 14 concerns concern NNS cord-010119-t1x9gknd 9434 15 , , , cord-010119-t1x9gknd 9434 16 especially especially RB cord-010119-t1x9gknd 9434 17 in in IN cord-010119-t1x9gknd 9434 18 endemic endemic JJ cord-010119-t1x9gknd 9434 19 areas area NNS cord-010119-t1x9gknd 9434 20 . . . cord-010119-t1x9gknd 9435 1 The the DT cord-010119-t1x9gknd 9435 2 high high JJ cord-010119-t1x9gknd 9435 3 mortality mortality NN cord-010119-t1x9gknd 9435 4 rate rate NN cord-010119-t1x9gknd 9435 5 , , , cord-010119-t1x9gknd 9435 6 especially especially RB cord-010119-t1x9gknd 9435 7 for for IN cord-010119-t1x9gknd 9435 8 critically critically RB cord-010119-t1x9gknd 9435 9 ill ill JJ cord-010119-t1x9gknd 9435 10 patients patient NNS cord-010119-t1x9gknd 9435 11 , , , cord-010119-t1x9gknd 9435 12 which which WDT cord-010119-t1x9gknd 9435 13 often often RB cord-010119-t1x9gknd 9435 14 require require VBP cord-010119-t1x9gknd 9435 15 blood blood NN cord-010119-t1x9gknd 9435 16 transfusion transfusion NN cord-010119-t1x9gknd 9435 17 , , , cord-010119-t1x9gknd 9435 18 raises raise VBZ cord-010119-t1x9gknd 9435 19 the the DT cord-010119-t1x9gknd 9435 20 need need NN cord-010119-t1x9gknd 9435 21 for for IN cord-010119-t1x9gknd 9435 22 a a DT cord-010119-t1x9gknd 9435 23 method method NN cord-010119-t1x9gknd 9435 24 to to TO cord-010119-t1x9gknd 9435 25 safely safely RB cord-010119-t1x9gknd 9435 26 exclude exclude VB cord-010119-t1x9gknd 9435 27 MERS MERS NNP cord-010119-t1x9gknd 9435 28 CoV cov NN cord-010119-t1x9gknd 9435 29 contamination contamination NN cord-010119-t1x9gknd 9435 30 of of IN cord-010119-t1x9gknd 9435 31 blood blood NN cord-010119-t1x9gknd 9435 32 products product NNS cord-010119-t1x9gknd 9435 33 . . . cord-010119-t1x9gknd 9436 1 Pathogen Pathogen NNP cord-010119-t1x9gknd 9436 2 Reduction Reduction NNP cord-010119-t1x9gknd 9436 3 with with IN cord-010119-t1x9gknd 9436 4 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 9436 5 / / SYM cord-010119-t1x9gknd 9436 6 UVA UVA NNP cord-010119-t1x9gknd 9436 7 technology technology NN cord-010119-t1x9gknd 9436 8 is be VBZ cord-010119-t1x9gknd 9436 9 a a DT cord-010119-t1x9gknd 9436 10 widely widely RB cord-010119-t1x9gknd 9436 11 established establish VBN cord-010119-t1x9gknd 9436 12 technology technology NN cord-010119-t1x9gknd 9436 13 with with IN cord-010119-t1x9gknd 9436 14 a a DT cord-010119-t1x9gknd 9436 15 broad broad JJ cord-010119-t1x9gknd 9436 16 range range NN cord-010119-t1x9gknd 9436 17 of of IN cord-010119-t1x9gknd 9436 18 data datum NNS cord-010119-t1x9gknd 9436 19 supporting support VBG cord-010119-t1x9gknd 9436 20 clinical clinical JJ cord-010119-t1x9gknd 9436 21 efficacy efficacy NN cord-010119-t1x9gknd 9436 22 and and CC cord-010119-t1x9gknd 9436 23 safety safety NN cord-010119-t1x9gknd 9436 24 of of IN cord-010119-t1x9gknd 9436 25 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 9436 26 / / SYM cord-010119-t1x9gknd 9436 27 UVA UVA NNP cord-010119-t1x9gknd 9436 28 treated treat VBD cord-010119-t1x9gknd 9436 29 blood blood NN cord-010119-t1x9gknd 9436 30 products product NNS cord-010119-t1x9gknd 9436 31 . . . cord-010119-t1x9gknd 9437 1 The the DT cord-010119-t1x9gknd 9437 2 aim aim NN cord-010119-t1x9gknd 9437 3 of of IN cord-010119-t1x9gknd 9437 4 the the DT cord-010119-t1x9gknd 9437 5 study study NN cord-010119-t1x9gknd 9437 6 is be VBZ cord-010119-t1x9gknd 9437 7 the the DT cord-010119-t1x9gknd 9437 8 assessment assessment NN cord-010119-t1x9gknd 9437 9 of of IN cord-010119-t1x9gknd 9437 10 the the DT cord-010119-t1x9gknd 9437 11 MERS MERS NNP cord-010119-t1x9gknd 9437 12 CoV CoV NNP cord-010119-t1x9gknd 9437 13 inactivation inactivation NN cord-010119-t1x9gknd 9437 14 efficacy efficacy NN cord-010119-t1x9gknd 9437 15 in in IN cord-010119-t1x9gknd 9437 16 human human JJ cord-010119-t1x9gknd 9437 17 plasma plasma NN cord-010119-t1x9gknd 9437 18 with with IN cord-010119-t1x9gknd 9437 19 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 9437 20 / / SYM cord-010119-t1x9gknd 9437 21 UVA UVA NNP cord-010119-t1x9gknd 9437 22 pathogen pathogen NN cord-010119-t1x9gknd 9437 23 inactivation inactivation NN cord-010119-t1x9gknd 9437 24 technology technology NN cord-010119-t1x9gknd 9437 25 to to TO cord-010119-t1x9gknd 9437 26 safely safely RB cord-010119-t1x9gknd 9437 27 exclude exclude VB cord-010119-t1x9gknd 9437 28 the the DT cord-010119-t1x9gknd 9437 29 presence presence NN cord-010119-t1x9gknd 9437 30 of of IN cord-010119-t1x9gknd 9437 31 infectious infectious JJ cord-010119-t1x9gknd 9437 32 virus virus NN cord-010119-t1x9gknd 9437 33 in in IN cord-010119-t1x9gknd 9437 34 human human JJ cord-010119-t1x9gknd 9437 35 plasma plasma NN cord-010119-t1x9gknd 9437 36 units unit NNS cord-010119-t1x9gknd 9437 37 . . . cord-010119-t1x9gknd 9438 1 Pre Pre NNP cord-010119-t1x9gknd 9438 2 - - NNP cord-010119-t1x9gknd 9438 3 UVA UVA NNP cord-010119-t1x9gknd 9438 4 Titer Titer NNP cord-010119-t1x9gknd 9438 5 Post Post NNP cord-010119-t1x9gknd 9438 6 - - NNP cord-010119-t1x9gknd 9438 7 UVA UVA NNP cord-010119-t1x9gknd 9438 8 Titer Titer NNP cord-010119-t1x9gknd 9438 9 Log Log NNP cord-010119-t1x9gknd 9438 10 10 10 CD cord-010119-t1x9gknd 9438 11 Reduction Reduction NNP cord-010119-t1x9gknd 9438 12 / / SYM cord-010119-t1x9gknd 9438 13 mL ml NN cord-010119-t1x9gknd 9439 1 ( ( -LRB- cord-010119-t1x9gknd 9439 2 log log VB cord-010119-t1x9gknd 9439 3 10 10 CD cord-010119-t1x9gknd 9439 4 /mL /mL . cord-010119-t1x9gknd 9439 5 ) ) -RRB- cord-010119-t1x9gknd 9440 1 47%Plasma/ 47%plasma/ CD cord-010119-t1x9gknd 9440 2 53 53 CD cord-010119-t1x9gknd 9440 3 % % NN cord-010119-t1x9gknd 9441 1 PAS pas NN cord-010119-t1x9gknd 9441 2 E E NNP cord-010119-t1x9gknd 9441 3 .coli .coli . cord-010119-t1x9gknd 9442 1 6.0 6.0 CD cord-010119-t1x9gknd 9442 2 < < XX cord-010119-t1x9gknd 9442 3 -1.0 -1.0 XX cord-010119-t1x9gknd 9442 4 > > XX cord-010119-t1x9gknd 9443 1 6.0 6.0 CD cord-010119-t1x9gknd 9443 2 E. E. NNP cord-010119-t1x9gknd 9443 3 cloacae cloacae VBD cord-010119-t1x9gknd 9443 4 6.4 6.4 CD cord-010119-t1x9gknd 9443 5 < < XX cord-010119-t1x9gknd 9443 6 -1.0 -1.0 XX cord-010119-t1x9gknd 9444 1 > > XX cord-010119-t1x9gknd 9445 1 6.4 6.4 CD cord-010119-t1x9gknd 9445 2 K. K. NNP cord-010119-t1x9gknd 9445 3 pneumoniae pneumoniae NN cord-010119-t1x9gknd 9445 4 6.6 6.6 CD cord-010119-t1x9gknd 9445 5 < < XX cord-010119-t1x9gknd 9445 6 20.1 20.1 CD cord-010119-t1x9gknd 9445 7 > > SYM cord-010119-t1x9gknd 9445 8 6.5 6.5 CD cord-010119-t1x9gknd 9445 9 S. S. NNP cord-010119-t1x9gknd 9445 10 aureus aureus NN cord-010119-t1x9gknd 9445 11 6.7 6.7 CD cord-010119-t1x9gknd 9445 12 < < XX cord-010119-t1x9gknd 9445 13 -1.0 -1.0 XX cord-010119-t1x9gknd 9446 1 > > XX cord-010119-t1x9gknd 9447 1 6.7 6.7 CD cord-010119-t1x9gknd 9447 2 Blue blue JJ cord-010119-t1x9gknd 9447 3 Tongue Tongue NNP cord-010119-t1x9gknd 9447 4 Virus virus NN cord-010119-t1x9gknd 9447 5 4.9 4.9 CD cord-010119-t1x9gknd 9447 6 < < XX cord-010119-t1x9gknd 9447 7 -1.0 -1.0 XX cord-010119-t1x9gknd 9448 1 > > XX cord-010119-t1x9gknd 9449 1 4.9 4.9 CD cord-010119-t1x9gknd 9449 2 Bovine bovine JJ cord-010119-t1x9gknd 9449 3 Viral Viral NNP cord-010119-t1x9gknd 9449 4 Diarrhea Diarrhea NNP cord-010119-t1x9gknd 9449 5 Virus virus NN cord-010119-t1x9gknd 9449 6 4.6 4.6 CD cord-010119-t1x9gknd 9449 7 < < XX cord-010119-t1x9gknd 9449 8 -1.0 -1.0 XX cord-010119-t1x9gknd 9449 9 > > XX cord-010119-t1x9gknd 9450 1 4.6 4.6 CD cord-010119-t1x9gknd 9450 2 Adenovirus-5 Adenovirus-5 NNP cord-010119-t1x9gknd 9450 3 1 1 CD cord-010119-t1x9gknd 9450 4 3.9 3.9 CD cord-010119-t1x9gknd 9450 5 < < XX cord-010119-t1x9gknd 9450 6 -0.6 -0.6 XX cord-010119-t1x9gknd 9451 1 > > XX cord-010119-t1x9gknd 9452 1 3.9 3.9 CD cord-010119-t1x9gknd 9452 2 100%Plasma 100%plasma CD cord-010119-t1x9gknd 9452 3 K. K. NNP cord-010119-t1x9gknd 9452 4 pneumoniae pneumoniae NN cord-010119-t1x9gknd 9452 5 1 1 CD cord-010119-t1x9gknd 9453 1 6.5 6.5 CD cord-010119-t1x9gknd 9453 2 -0.5 -0.5 XX cord-010119-t1x9gknd 9453 3 > > XX cord-010119-t1x9gknd 9453 4 6.5 6.5 CD cord-010119-t1x9gknd 9453 5 S. S. NNP cord-010119-t1x9gknd 9453 6 aureus aureus NN cord-010119-t1x9gknd 9453 7 1 1 CD cord-010119-t1x9gknd 9453 8 6.2 6.2 CD cord-010119-t1x9gknd 9453 9 < < XX cord-010119-t1x9gknd 9453 10 -0.7 -0.7 XX cord-010119-t1x9gknd 9454 1 > > XX cord-010119-t1x9gknd 9455 1 6.2 6.2 CD cord-010119-t1x9gknd 9455 2 Adenovirus-5 adenovirus-5 NN cord-010119-t1x9gknd 9455 3 1 1 CD cord-010119-t1x9gknd 9455 4 4.5 4.5 CD cord-010119-t1x9gknd 9455 5 < < XX cord-010119-t1x9gknd 9455 6 -0.6 -0.6 XX cord-010119-t1x9gknd 9456 1 > > XX cord-010119-t1x9gknd 9457 1 4.5 4.5 CD cord-010119-t1x9gknd 9457 2 1 1 CD cord-010119-t1x9gknd 9457 3 N53 N53 NNP cord-010119-t1x9gknd 9457 4 190A 190a CD cord-010119-t1x9gknd 9457 5 TRANSFUSION transfusion NN cord-010119-t1x9gknd 9457 6 2017 2017 CD cord-010119-t1x9gknd 9457 7 Vol Vol NNP cord-010119-t1x9gknd 9457 8 . . . cord-010119-t1x9gknd 9458 1 57 57 CD cord-010119-t1x9gknd 9459 1 Supplement supplement NN cord-010119-t1x9gknd 9459 2 S3 S3 NNP cord-010119-t1x9gknd 9459 3 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 9459 4 Study Study NNP cord-010119-t1x9gknd 9459 5 Design Design NNP cord-010119-t1x9gknd 9459 6 / / SYM cord-010119-t1x9gknd 9459 7 Method method NN cord-010119-t1x9gknd 9459 8 : : : cord-010119-t1x9gknd 9460 1 Four four CD cord-010119-t1x9gknd 9460 2 therapeutic therapeutic JJ cord-010119-t1x9gknd 9460 3 human human JJ cord-010119-t1x9gknd 9460 4 plasma plasma NN cord-010119-t1x9gknd 9460 5 units unit NNS cord-010119-t1x9gknd 9460 6 were be VBD cord-010119-t1x9gknd 9460 7 spiked spike VBN cord-010119-t1x9gknd 9460 8 with with IN cord-010119-t1x9gknd 9460 9 a a DT cord-010119-t1x9gknd 9460 10 fully fully RB cord-010119-t1x9gknd 9460 11 characterized characterize VBN cord-010119-t1x9gknd 9460 12 MERS MERS NNP cord-010119-t1x9gknd 9460 13 CoV CoV NNP cord-010119-t1x9gknd 9460 14 clinical clinical JJ cord-010119-t1x9gknd 9460 15 isolate isolate NN cord-010119-t1x9gknd 9460 16 followed follow VBN cord-010119-t1x9gknd 9460 17 by by IN cord-010119-t1x9gknd 9460 18 pathogen pathogen NN cord-010119-t1x9gknd 9460 19 inactivation inactivation NN cord-010119-t1x9gknd 9460 20 with with IN cord-010119-t1x9gknd 9460 21 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 9460 22 / / SYM cord-010119-t1x9gknd 9460 23 UVA UVA NNP cord-010119-t1x9gknd 9460 24 ( ( -LRB- cord-010119-t1x9gknd 9460 25 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 9460 26 Blood blood NN cord-010119-t1x9gknd 9460 27 System System NNP cord-010119-t1x9gknd 9460 28 , , , cord-010119-t1x9gknd 9460 29 Cerus Cerus NNP cord-010119-t1x9gknd 9460 30 Corporation Corporation NNP cord-010119-t1x9gknd 9460 31 ) ) -RRB- cord-010119-t1x9gknd 9460 32 at at IN cord-010119-t1x9gknd 9460 33 four four CD cord-010119-t1x9gknd 9460 34 different different JJ cord-010119-t1x9gknd 9460 35 days day NNS cord-010119-t1x9gknd 9460 36 . . . cord-010119-t1x9gknd 9461 1 Pathogen pathogen NN cord-010119-t1x9gknd 9461 2 reduced reduce VBN cord-010119-t1x9gknd 9461 3 samples sample NNS cord-010119-t1x9gknd 9461 4 were be VBD cord-010119-t1x9gknd 9461 5 taken take VBN cord-010119-t1x9gknd 9461 6 preand preand JJ cord-010119-t1x9gknd 9461 7 post post JJ cord-010119-t1x9gknd 9461 8 - - JJ cord-010119-t1x9gknd 9461 9 pathogen pathogen JJ cord-010119-t1x9gknd 9461 10 reduction reduction NN cord-010119-t1x9gknd 9461 11 after after IN cord-010119-t1x9gknd 9461 12 various various JJ cord-010119-t1x9gknd 9461 13 processing processing NN cord-010119-t1x9gknd 9461 14 steps step NNS cord-010119-t1x9gknd 9461 15 to to TO cord-010119-t1x9gknd 9461 16 assess assess VB cord-010119-t1x9gknd 9461 17 the the DT cord-010119-t1x9gknd 9461 18 infectious infectious JJ cord-010119-t1x9gknd 9461 19 titer titer NN cord-010119-t1x9gknd 9461 20 by by IN cord-010119-t1x9gknd 9461 21 plaque plaque NN cord-010119-t1x9gknd 9461 22 assay assay NN cord-010119-t1x9gknd 9461 23 titration titration NN cord-010119-t1x9gknd 9461 24 and and CC cord-010119-t1x9gknd 9461 25 the the DT cord-010119-t1x9gknd 9461 26 genomic genomic JJ cord-010119-t1x9gknd 9461 27 titer titer NN cord-010119-t1x9gknd 9461 28 by by IN cord-010119-t1x9gknd 9461 29 real real JJ cord-010119-t1x9gknd 9461 30 - - HYPH cord-010119-t1x9gknd 9461 31 time time NN cord-010119-t1x9gknd 9461 32 - - HYPH cord-010119-t1x9gknd 9461 33 PCR pcr NN cord-010119-t1x9gknd 9461 34 . . . cord-010119-t1x9gknd 9462 1 Samples sample NNS cord-010119-t1x9gknd 9462 2 post post VBP cord-010119-t1x9gknd 9462 3 pathogen pathogen NN cord-010119-t1x9gknd 9462 4 reduction reduction NN cord-010119-t1x9gknd 9462 5 have have VBP cord-010119-t1x9gknd 9462 6 been be VBN cord-010119-t1x9gknd 9462 7 passaged passage VBN cord-010119-t1x9gknd 9462 8 3 3 CD cord-010119-t1x9gknd 9462 9 times time NNS cord-010119-t1x9gknd 9462 10 up up IN cord-010119-t1x9gknd 9462 11 to to TO cord-010119-t1x9gknd 9462 12 9 9 CD cord-010119-t1x9gknd 9462 13 days day NNS cord-010119-t1x9gknd 9462 14 , , , cord-010119-t1x9gknd 9462 15 assessing assess VBG cord-010119-t1x9gknd 9462 16 the the DT cord-010119-t1x9gknd 9462 17 infectious infectious JJ cord-010119-t1x9gknd 9462 18 titer titer NN cord-010119-t1x9gknd 9462 19 and and CC cord-010119-t1x9gknd 9462 20 genomic genomic JJ cord-010119-t1x9gknd 9462 21 titer titer NN cord-010119-t1x9gknd 9462 22 every every DT cord-010119-t1x9gknd 9462 23 3 3 CD cord-010119-t1x9gknd 9462 24 rd rd NNP cord-010119-t1x9gknd 9462 25 day day NN cord-010119-t1x9gknd 9462 26 to to TO cord-010119-t1x9gknd 9462 27 exclude exclude VB cord-010119-t1x9gknd 9462 28 the the DT cord-010119-t1x9gknd 9462 29 presence presence NN cord-010119-t1x9gknd 9462 30 of of IN cord-010119-t1x9gknd 9462 31 low low JJ cord-010119-t1x9gknd 9462 32 - - HYPH cord-010119-t1x9gknd 9462 33 titer titer NN cord-010119-t1x9gknd 9462 34 infectious infectious JJ cord-010119-t1x9gknd 9462 35 particles particle NNS cord-010119-t1x9gknd 9462 36 . . . cord-010119-t1x9gknd 9463 1 Results result NNS cord-010119-t1x9gknd 9463 2 / / SYM cord-010119-t1x9gknd 9463 3 Finding finding NN cord-010119-t1x9gknd 9463 4 : : : cord-010119-t1x9gknd 9464 1 All all DT cord-010119-t1x9gknd 9464 2 viral viral JJ cord-010119-t1x9gknd 9464 3 particles particle NNS cord-010119-t1x9gknd 9464 4 in in IN cord-010119-t1x9gknd 9464 5 the the DT cord-010119-t1x9gknd 9464 6 plasma plasma NN cord-010119-t1x9gknd 9464 7 units unit NNS cord-010119-t1x9gknd 9464 8 were be VBD cord-010119-t1x9gknd 9464 9 completely completely RB cord-010119-t1x9gknd 9464 10 inactivated inactivate VBN cord-010119-t1x9gknd 9464 11 with with IN cord-010119-t1x9gknd 9464 12 an an DT cord-010119-t1x9gknd 9464 13 average average JJ cord-010119-t1x9gknd 9464 14 efficacy efficacy NN cord-010119-t1x9gknd 9464 15 of of IN cord-010119-t1x9gknd 9464 16 ! ! . cord-010119-t1x9gknd 9465 1 5.8 5.8 CD cord-010119-t1x9gknd 9465 2 log log NN cord-010119-t1x9gknd 9465 3 infectious infectious JJ cord-010119-t1x9gknd 9465 4 titer titer NN cord-010119-t1x9gknd 9465 5 . . . cord-010119-t1x9gknd 9466 1 No no DT cord-010119-t1x9gknd 9466 2 viral viral JJ cord-010119-t1x9gknd 9466 3 replication replication NN cord-010119-t1x9gknd 9466 4 was be VBD cord-010119-t1x9gknd 9466 5 observed observe VBN cord-010119-t1x9gknd 9466 6 after after IN cord-010119-t1x9gknd 9466 7 9 9 CD cord-010119-t1x9gknd 9466 8 days day NNS cord-010119-t1x9gknd 9466 9 of of IN cord-010119-t1x9gknd 9466 10 passaging passage VBG cord-010119-t1x9gknd 9466 11 post post NN cord-010119-t1x9gknd 9466 12 inactivation inactivation NN cord-010119-t1x9gknd 9466 13 . . . cord-010119-t1x9gknd 9467 1 The the DT cord-010119-t1x9gknd 9467 2 genomic genomic JJ cord-010119-t1x9gknd 9467 3 titer titer NN cord-010119-t1x9gknd 9467 4 was be VBD cord-010119-t1x9gknd 9467 5 only only RB cord-010119-t1x9gknd 9467 6 slightly slightly RB cord-010119-t1x9gknd 9467 7 affected affect VBN cord-010119-t1x9gknd 9467 8 by by IN cord-010119-t1x9gknd 9467 9 pathogen pathogen NN cord-010119-t1x9gknd 9467 10 inactivation inactivation NN cord-010119-t1x9gknd 9467 11 , , , cord-010119-t1x9gknd 9467 12 which which WDT cord-010119-t1x9gknd 9467 13 is be VBZ cord-010119-t1x9gknd 9467 14 designed design VBN cord-010119-t1x9gknd 9467 15 to to TO cord-010119-t1x9gknd 9467 16 target target VB cord-010119-t1x9gknd 9467 17 the the DT cord-010119-t1x9gknd 9467 18 infectious infectious JJ cord-010119-t1x9gknd 9467 19 titer titer NN cord-010119-t1x9gknd 9467 20 , , , cord-010119-t1x9gknd 9467 21 but but CC cord-010119-t1x9gknd 9467 22 not not RB cord-010119-t1x9gknd 9467 23 the the DT cord-010119-t1x9gknd 9467 24 physical physical JJ cord-010119-t1x9gknd 9467 25 titer titer NN cord-010119-t1x9gknd 9467 26 . . . cord-010119-t1x9gknd 9468 1 Conclusion conclusion NN cord-010119-t1x9gknd 9468 2 : : : cord-010119-t1x9gknd 9469 1 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 9469 2 alone alone RB cord-010119-t1x9gknd 9469 3 had have VBD cord-010119-t1x9gknd 9469 4 a a DT cord-010119-t1x9gknd 9469 5 slight slight JJ cord-010119-t1x9gknd 9469 6 effect effect NN cord-010119-t1x9gknd 9469 7 on on IN cord-010119-t1x9gknd 9469 8 the the DT cord-010119-t1x9gknd 9469 9 infectious infectious JJ cord-010119-t1x9gknd 9469 10 titer titer NN cord-010119-t1x9gknd 9469 11 while while IN cord-010119-t1x9gknd 9469 12 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 9469 13 / / SYM cord-010119-t1x9gknd 9469 14 UVA UVA NNP cord-010119-t1x9gknd 9469 15 effectively effectively RB cord-010119-t1x9gknd 9469 16 inactivated inactivate VBD cord-010119-t1x9gknd 9469 17 all all DT cord-010119-t1x9gknd 9469 18 infectious infectious JJ cord-010119-t1x9gknd 9469 19 MERS MERS NNP cord-010119-t1x9gknd 9469 20 CoV cov NN cord-010119-t1x9gknd 9469 21 viral viral JJ cord-010119-t1x9gknd 9469 22 particles particle NNS cord-010119-t1x9gknd 9469 23 in in IN cord-010119-t1x9gknd 9469 24 the the DT cord-010119-t1x9gknd 9469 25 plasma plasma NN cord-010119-t1x9gknd 9469 26 units unit NNS cord-010119-t1x9gknd 9469 27 with with IN cord-010119-t1x9gknd 9469 28 an an DT cord-010119-t1x9gknd 9469 29 inactivation inactivation NN cord-010119-t1x9gknd 9469 30 efficacy efficacy NN cord-010119-t1x9gknd 9469 31 above above IN cord-010119-t1x9gknd 9469 32 5 5 CD cord-010119-t1x9gknd 9469 33 logs log VBZ cord-010119-t1x9gknd 9469 34 infectious infectious JJ cord-010119-t1x9gknd 9469 35 titer titer NN cord-010119-t1x9gknd 9469 36 , , , cord-010119-t1x9gknd 9469 37 giving give VBG cord-010119-t1x9gknd 9469 38 evidence evidence NN cord-010119-t1x9gknd 9469 39 for for IN cord-010119-t1x9gknd 9469 40 improved improved JJ cord-010119-t1x9gknd 9469 41 blood blood NN cord-010119-t1x9gknd 9469 42 safety safety NN cord-010119-t1x9gknd 9469 43 of of IN cord-010119-t1x9gknd 9469 44 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 9469 45 / / SYM cord-010119-t1x9gknd 9469 46 UVA UVA NNP cord-010119-t1x9gknd 9469 47 treated treat VBD cord-010119-t1x9gknd 9469 48 plasma plasma NN cord-010119-t1x9gknd 9469 49 in in IN cord-010119-t1x9gknd 9469 50 MERS MERS NNP cord-010119-t1x9gknd 9469 51 CoV CoV NNP cord-010119-t1x9gknd 9469 52 endemic endemic JJ cord-010119-t1x9gknd 9469 53 regions region NNS cord-010119-t1x9gknd 9469 54 . . . cord-010119-t1x9gknd 9470 1 Estimating estimate VBG cord-010119-t1x9gknd 9470 2 the the DT cord-010119-t1x9gknd 9470 3 Prevalence Prevalence NNP cord-010119-t1x9gknd 9470 4 and and CC cord-010119-t1x9gknd 9470 5 Incidence incidence NN cord-010119-t1x9gknd 9470 6 in in IN cord-010119-t1x9gknd 9470 7 a a DT cord-010119-t1x9gknd 9470 8 National National NNP cord-010119-t1x9gknd 9470 9 Blood Blood NNP cord-010119-t1x9gknd 9470 10 Service Service NNP cord-010119-t1x9gknd 9470 11 in in IN cord-010119-t1x9gknd 9470 12 Taiwan Taiwan NNP cord-010119-t1x9gknd 9470 13 for for IN cord-010119-t1x9gknd 9470 14 HCV HCV NNP cord-010119-t1x9gknd 9470 15 Eradication Eradication NNP cord-010119-t1x9gknd 9470 16 Program Program NNP cord-010119-t1x9gknd 9470 17 Yun Yun NNP cord-010119-t1x9gknd 9470 18 - - HYPH cord-010119-t1x9gknd 9470 19 Yuan Yuan NNP cord-010119-t1x9gknd 9470 20 Chen Chen NNP cord-010119-t1x9gknd 9471 1 * * NFP cord-010119-t1x9gknd 9471 2 1 1 CD cord-010119-t1x9gknd 9471 3 , , , cord-010119-t1x9gknd 9471 4 Jen Jen NNP cord-010119-t1x9gknd 9471 5 - - HYPH cord-010119-t1x9gknd 9471 6 Wei Wei NNP cord-010119-t1x9gknd 9471 7 Chen Chen NNP cord-010119-t1x9gknd 9471 8 1 1 CD cord-010119-t1x9gknd 9471 9 , , , cord-010119-t1x9gknd 9471 10 Chi Chi NNP cord-010119-t1x9gknd 9471 11 - - HYPH cord-010119-t1x9gknd 9471 12 Ling Ling NNP cord-010119-t1x9gknd 9471 13 Chen Chen NNP cord-010119-t1x9gknd 9471 14 2 2 CD cord-010119-t1x9gknd 9471 15 , , , cord-010119-t1x9gknd 9471 16 Sheng Sheng NNP cord-010119-t1x9gknd 9471 17 - - HYPH cord-010119-t1x9gknd 9471 18 Nan Nan NNP cord-010119-t1x9gknd 9471 19 Lu Lu NNP cord-010119-t1x9gknd 9471 20 3 3 CD cord-010119-t1x9gknd 9471 21 and and CC cord-010119-t1x9gknd 9471 22 Pei Pei NNP cord-010119-t1x9gknd 9471 23 - - HYPH cord-010119-t1x9gknd 9471 24 Jer Jer NNP cord-010119-t1x9gknd 9471 25 Chen Chen NNP cord-010119-t1x9gknd 9471 26 2 2 CD cord-010119-t1x9gknd 9471 27 . . . cord-010119-t1x9gknd 9472 1 1 1 LS cord-010119-t1x9gknd 9472 2 Department Department NNP cord-010119-t1x9gknd 9472 3 of of IN cord-010119-t1x9gknd 9472 4 Research Research NNP cord-010119-t1x9gknd 9472 5 , , , cord-010119-t1x9gknd 9472 6 Head Head NNP cord-010119-t1x9gknd 9472 7 Office Office NNP cord-010119-t1x9gknd 9472 8 , , , cord-010119-t1x9gknd 9472 9 Taiwan Taiwan NNP cord-010119-t1x9gknd 9472 10 Blood Blood NNP cord-010119-t1x9gknd 9472 11 Services Services NNP cord-010119-t1x9gknd 9472 12 Foundation Foundation NNP cord-010119-t1x9gknd 9472 13 , , , cord-010119-t1x9gknd 9472 14 2 2 CD cord-010119-t1x9gknd 9472 15 Graduate Graduate NNP cord-010119-t1x9gknd 9472 16 Institute Institute NNP cord-010119-t1x9gknd 9472 17 of of IN cord-010119-t1x9gknd 9472 18 Clinical Clinical NNP cord-010119-t1x9gknd 9472 19 Medicine Medicine NNP cord-010119-t1x9gknd 9472 20 , , , cord-010119-t1x9gknd 9472 21 College College NNP cord-010119-t1x9gknd 9472 22 of of IN cord-010119-t1x9gknd 9472 23 Medicine Medicine NNP cord-010119-t1x9gknd 9472 24 , , , cord-010119-t1x9gknd 9472 25 National National NNP cord-010119-t1x9gknd 9472 26 Taiwan Taiwan NNP cord-010119-t1x9gknd 9472 27 University University NNP cord-010119-t1x9gknd 9472 28 , , , cord-010119-t1x9gknd 9472 29 3 3 CD cord-010119-t1x9gknd 9472 30 Division Division NNP cord-010119-t1x9gknd 9472 31 of of IN cord-010119-t1x9gknd 9472 32 Hepatogastroenterology Hepatogastroenterology NNP cord-010119-t1x9gknd 9472 33 , , , cord-010119-t1x9gknd 9472 34 Department Department NNP cord-010119-t1x9gknd 9472 35 of of IN cord-010119-t1x9gknd 9472 36 Internal Internal NNP cord-010119-t1x9gknd 9472 37 Medicine Medicine NNP cord-010119-t1x9gknd 9472 38 , , , cord-010119-t1x9gknd 9472 39 Kaohsiung Kaohsiung NNP cord-010119-t1x9gknd 9472 40 Chang Chang NNP cord-010119-t1x9gknd 9472 41 Gung Gung NNP cord-010119-t1x9gknd 9472 42 Memorial Memorial NNP cord-010119-t1x9gknd 9472 43 Hospital Hospital NNP cord-010119-t1x9gknd 9472 44 Background Background NNP cord-010119-t1x9gknd 9472 45 / / SYM cord-010119-t1x9gknd 9472 46 Case Case NNP cord-010119-t1x9gknd 9472 47 Studies Studies NNPS cord-010119-t1x9gknd 9472 48 : : : cord-010119-t1x9gknd 9472 49 World World NNP cord-010119-t1x9gknd 9472 50 Health Health NNP cord-010119-t1x9gknd 9472 51 Organization Organization NNP cord-010119-t1x9gknd 9472 52 ( ( -LRB- cord-010119-t1x9gknd 9472 53 WHO who WP cord-010119-t1x9gknd 9472 54 ) ) -RRB- cord-010119-t1x9gknd 9472 55 has have VBZ cord-010119-t1x9gknd 9472 56 set set VBN cord-010119-t1x9gknd 9472 57 a a DT cord-010119-t1x9gknd 9472 58 goal goal NN cord-010119-t1x9gknd 9472 59 to to TO cord-010119-t1x9gknd 9472 60 eliminate eliminate VB cord-010119-t1x9gknd 9472 61 HCV HCV NNP cord-010119-t1x9gknd 9472 62 by by IN cord-010119-t1x9gknd 9472 63 2030 2030 CD cord-010119-t1x9gknd 9472 64 , , , cord-010119-t1x9gknd 9472 65 and and CC cord-010119-t1x9gknd 9472 66 the the DT cord-010119-t1x9gknd 9472 67 epidemiological epidemiological JJ cord-010119-t1x9gknd 9472 68 indicators indicator NNS cord-010119-t1x9gknd 9472 69 generated generate VBN cord-010119-t1x9gknd 9472 70 from from IN cord-010119-t1x9gknd 9472 71 a a DT cord-010119-t1x9gknd 9472 72 national national JJ cord-010119-t1x9gknd 9472 73 blood blood NN cord-010119-t1x9gknd 9472 74 service service NN cord-010119-t1x9gknd 9472 75 is be VBZ cord-010119-t1x9gknd 9472 76 useful useful JJ cord-010119-t1x9gknd 9472 77 to to TO cord-010119-t1x9gknd 9472 78 monitor monitor VB cord-010119-t1x9gknd 9472 79 the the DT cord-010119-t1x9gknd 9472 80 effectiveness effectiveness NN cord-010119-t1x9gknd 9472 81 . . . cord-010119-t1x9gknd 9473 1 This this DT cord-010119-t1x9gknd 9473 2 study study NN cord-010119-t1x9gknd 9473 3 aimed aim VBD cord-010119-t1x9gknd 9473 4 to to TO cord-010119-t1x9gknd 9473 5 evaluate evaluate VB cord-010119-t1x9gknd 9473 6 the the DT cord-010119-t1x9gknd 9473 7 prevalence prevalence NN cord-010119-t1x9gknd 9473 8 and and CC cord-010119-t1x9gknd 9473 9 incidence incidence NN cord-010119-t1x9gknd 9473 10 of of IN cord-010119-t1x9gknd 9473 11 HCV HCV NNP cord-010119-t1x9gknd 9473 12 infection infection NN cord-010119-t1x9gknd 9473 13 in in IN cord-010119-t1x9gknd 9473 14 Taiwan Taiwan NNP cord-010119-t1x9gknd 9473 15 . . . cord-010119-t1x9gknd 9474 1 Study Study NNP cord-010119-t1x9gknd 9474 2 Design Design NNP cord-010119-t1x9gknd 9474 3 / / SYM cord-010119-t1x9gknd 9474 4 Method method NN cord-010119-t1x9gknd 9474 5 : : : cord-010119-t1x9gknd 9475 1 In in IN cord-010119-t1x9gknd 9475 2 Taiwan Taiwan NNP cord-010119-t1x9gknd 9475 3 , , , cord-010119-t1x9gknd 9475 4 anti anti JJ cord-010119-t1x9gknd 9475 5 - - JJ cord-010119-t1x9gknd 9475 6 HCV HCV NNP cord-010119-t1x9gknd 9475 7 ( ( -LRB- cord-010119-t1x9gknd 9475 8 since since IN cord-010119-t1x9gknd 9475 9 1992 1992 CD cord-010119-t1x9gknd 9475 10 ) ) -RRB- cord-010119-t1x9gknd 9475 11 and and CC cord-010119-t1x9gknd 9475 12 8-sample 8-sample CD cord-010119-t1x9gknd 9475 13 mini mini JJ cord-010119-t1x9gknd 9475 14 - - HYPH cord-010119-t1x9gknd 9475 15 pools pool NNS cord-010119-t1x9gknd 9475 16 triplex triplex JJ cord-010119-t1x9gknd 9475 17 nucleic nucleic JJ cord-010119-t1x9gknd 9475 18 acid acid NN cord-010119-t1x9gknd 9475 19 test test NN cord-010119-t1x9gknd 9475 20 of of IN cord-010119-t1x9gknd 9475 21 HCV HCV NNP cord-010119-t1x9gknd 9475 22 , , , cord-010119-t1x9gknd 9475 23 HBV HBV NNP cord-010119-t1x9gknd 9475 24 and and CC cord-010119-t1x9gknd 9475 25 HIV HIV NNP cord-010119-t1x9gknd 9475 26 ( ( -LRB- cord-010119-t1x9gknd 9475 27 since since IN cord-010119-t1x9gknd 9475 28 2013 2013 CD cord-010119-t1x9gknd 9475 29 ) ) -RRB- cord-010119-t1x9gknd 9475 30 have have VBP cord-010119-t1x9gknd 9475 31 been be VBN cord-010119-t1x9gknd 9475 32 used use VBN cord-010119-t1x9gknd 9475 33 in in IN cord-010119-t1x9gknd 9475 34 the the DT cord-010119-t1x9gknd 9475 35 routine routine JJ cord-010119-t1x9gknd 9475 36 blood blood NN cord-010119-t1x9gknd 9475 37 screening screening NN cord-010119-t1x9gknd 9475 38 . . . cord-010119-t1x9gknd 9476 1 Prevalence prevalence NN cord-010119-t1x9gknd 9476 2 of of IN cord-010119-t1x9gknd 9476 3 anti anti JJ cord-010119-t1x9gknd 9476 4 - - JJ cord-010119-t1x9gknd 9476 5 HCV HCV NNP cord-010119-t1x9gknd 9476 6 and and CC cord-010119-t1x9gknd 9476 7 HCV HCV NNP cord-010119-t1x9gknd 9476 8 RNA RNA NNP cord-010119-t1x9gknd 9476 9 were be VBD cord-010119-t1x9gknd 9476 10 estimated estimate VBN cord-010119-t1x9gknd 9476 11 in in IN cord-010119-t1x9gknd 9476 12 the the DT cord-010119-t1x9gknd 9476 13 first first JJ cord-010119-t1x9gknd 9476 14 - - HYPH cord-010119-t1x9gknd 9476 15 time time NN cord-010119-t1x9gknd 9476 16 donors donor NNS cord-010119-t1x9gknd 9476 17 during during IN cord-010119-t1x9gknd 9476 18 1999 1999 CD cord-010119-t1x9gknd 9476 19 - - SYM cord-010119-t1x9gknd 9476 20 2016 2016 CD cord-010119-t1x9gknd 9476 21 and and CC cord-010119-t1x9gknd 9476 22 2013 2013 CD cord-010119-t1x9gknd 9476 23 - - SYM cord-010119-t1x9gknd 9476 24 2016 2016 CD cord-010119-t1x9gknd 9476 25 , , , cord-010119-t1x9gknd 9476 26 respectively respectively RB cord-010119-t1x9gknd 9476 27 . . . cord-010119-t1x9gknd 9477 1 Age age NN cord-010119-t1x9gknd 9477 2 - - HYPH cord-010119-t1x9gknd 9477 3 standardized standardize VBN cord-010119-t1x9gknd 9477 4 prevalence prevalence NN cord-010119-t1x9gknd 9477 5 and and CC cord-010119-t1x9gknd 9477 6 its -PRON- PRP$ cord-010119-t1x9gknd 9477 7 95 95 CD cord-010119-t1x9gknd 9477 8 % % NN cord-010119-t1x9gknd 9477 9 confidence confidence NN cord-010119-t1x9gknd 9477 10 interval interval NN cord-010119-t1x9gknd 9477 11 ( ( -LRB- cord-010119-t1x9gknd 9477 12 95 95 CD cord-010119-t1x9gknd 9477 13 % % NN cord-010119-t1x9gknd 9477 14 CI CI NNP cord-010119-t1x9gknd 9477 15 ) ) -RRB- cord-010119-t1x9gknd 9477 16 were be VBD cord-010119-t1x9gknd 9477 17 calculated calculate VBN cord-010119-t1x9gknd 9477 18 with with IN cord-010119-t1x9gknd 9477 19 adjustment adjustment NN cord-010119-t1x9gknd 9477 20 of of IN cord-010119-t1x9gknd 9477 21 WHO WHO NNP cord-010119-t1x9gknd 9477 22 world world VBP cord-010119-t1x9gknd 9477 23 standard standard JJ cord-010119-t1x9gknd 9477 24 population population NN cord-010119-t1x9gknd 9477 25 2000 2000 CD cord-010119-t1x9gknd 9477 26 - - SYM cord-010119-t1x9gknd 9477 27 2025 2025 CD cord-010119-t1x9gknd 9477 28 . . . cord-010119-t1x9gknd 9478 1 For for IN cord-010119-t1x9gknd 9478 2 the the DT cord-010119-t1x9gknd 9478 3 incidence incidence NN cord-010119-t1x9gknd 9478 4 study study NN cord-010119-t1x9gknd 9478 5 , , , cord-010119-t1x9gknd 9478 6 donors donor NNS cord-010119-t1x9gknd 9478 7 who who WP cord-010119-t1x9gknd 9478 8 have have VBP cord-010119-t1x9gknd 9478 9 donated donate VBN cord-010119-t1x9gknd 9478 10 blood blood NN cord-010119-t1x9gknd 9478 11 two two CD cord-010119-t1x9gknd 9478 12 or or CC cord-010119-t1x9gknd 9478 13 more more JJR cord-010119-t1x9gknd 9478 14 times time NNS cord-010119-t1x9gknd 9478 15 during during IN cord-010119-t1x9gknd 9478 16 2013 2013 CD cord-010119-t1x9gknd 9478 17 - - SYM cord-010119-t1x9gknd 9478 18 2016 2016 CD cord-010119-t1x9gknd 9478 19 and and CC cord-010119-t1x9gknd 9478 20 who who WP cord-010119-t1x9gknd 9478 21 were be VBD cord-010119-t1x9gknd 9478 22 without without IN cord-010119-t1x9gknd 9478 23 a a DT cord-010119-t1x9gknd 9478 24 history history NN cord-010119-t1x9gknd 9478 25 of of IN cord-010119-t1x9gknd 9478 26 anti anti JJ cord-010119-t1x9gknd 9478 27 - - JJ cord-010119-t1x9gknd 9478 28 HCV HCV NNP cord-010119-t1x9gknd 9478 29 positive positive JJ cord-010119-t1x9gknd 9478 30 before before IN cord-010119-t1x9gknd 9478 31 the the DT cord-010119-t1x9gknd 9478 32 follow follow NN cord-010119-t1x9gknd 9478 33 - - HYPH cord-010119-t1x9gknd 9478 34 up up NN cord-010119-t1x9gknd 9478 35 period period NN cord-010119-t1x9gknd 9478 36 were be VBD cord-010119-t1x9gknd 9478 37 included include VBN cord-010119-t1x9gknd 9478 38 . . . cord-010119-t1x9gknd 9479 1 The the DT cord-010119-t1x9gknd 9479 2 incidence incidence NN cord-010119-t1x9gknd 9479 3 and and CC cord-010119-t1x9gknd 9479 4 its -PRON- PRP$ cord-010119-t1x9gknd 9479 5 95 95 CD cord-010119-t1x9gknd 9479 6 % % NN cord-010119-t1x9gknd 9479 7 confidence confidence NN cord-010119-t1x9gknd 9479 8 interval interval NN cord-010119-t1x9gknd 9479 9 was be VBD cord-010119-t1x9gknd 9479 10 estimated estimate VBN cord-010119-t1x9gknd 9479 11 from from IN cord-010119-t1x9gknd 9479 12 the the DT cord-010119-t1x9gknd 9479 13 number number NN cord-010119-t1x9gknd 9479 14 of of IN cord-010119-t1x9gknd 9479 15 new new JJ cord-010119-t1x9gknd 9479 16 HCV HCV NNP cord-010119-t1x9gknd 9479 17 RNA RNA NNP cord-010119-t1x9gknd 9479 18 positive positive JJ cord-010119-t1x9gknd 9479 19 cases case NNS cord-010119-t1x9gknd 9479 20 divided divide VBN cord-010119-t1x9gknd 9479 21 by by IN cord-010119-t1x9gknd 9479 22 the the DT cord-010119-t1x9gknd 9479 23 person person NN cord-010119-t1x9gknd 9479 24 - - HYPH cord-010119-t1x9gknd 9479 25 years year NNS cord-010119-t1x9gknd 9479 26 of of IN cord-010119-t1x9gknd 9479 27 follow follow NN cord-010119-t1x9gknd 9479 28 - - HYPH cord-010119-t1x9gknd 9479 29 up up NN cord-010119-t1x9gknd 9479 30 . . . cord-010119-t1x9gknd 9480 1 Results/ Results/ . cord-010119-t1x9gknd 9481 1 Finding finding NN cord-010119-t1x9gknd 9481 2 : : : cord-010119-t1x9gknd 9482 1 The the DT cord-010119-t1x9gknd 9482 2 crude crude JJ cord-010119-t1x9gknd 9482 3 prevalence prevalence NN cord-010119-t1x9gknd 9482 4 of of IN cord-010119-t1x9gknd 9482 5 anti anti JJ cord-010119-t1x9gknd 9482 6 - - JJ cord-010119-t1x9gknd 9482 7 HCV HCV NNP cord-010119-t1x9gknd 9482 8 in in IN cord-010119-t1x9gknd 9482 9 the the DT cord-010119-t1x9gknd 9482 10 first first JJ cord-010119-t1x9gknd 9482 11 - - HYPH cord-010119-t1x9gknd 9482 12 time time NN cord-010119-t1x9gknd 9482 13 donors donor NNS cord-010119-t1x9gknd 9482 14 was be VBD cord-010119-t1x9gknd 9482 15 dramatically dramatically RB cord-010119-t1x9gknd 9482 16 decreased decrease VBN cord-010119-t1x9gknd 9482 17 from from IN cord-010119-t1x9gknd 9482 18 15.2 15.2 CD cord-010119-t1x9gknd 9482 19 per per IN cord-010119-t1x9gknd 9482 20 1,000 1,000 CD cord-010119-t1x9gknd 9482 21 donors donor NNS cord-010119-t1x9gknd 9482 22 ( ( -LRB- cord-010119-t1x9gknd 9482 23 95 95 CD cord-010119-t1x9gknd 9482 24 % % NN cord-010119-t1x9gknd 9482 25 CI ci NN cord-010119-t1x9gknd 9482 26 : : : cord-010119-t1x9gknd 9482 27 14.8 14.8 CD cord-010119-t1x9gknd 9482 28 - - HYPH cord-010119-t1x9gknd 9482 29 15.7 15.7 CD cord-010119-t1x9gknd 9482 30 ) ) -RRB- cord-010119-t1x9gknd 9482 31 to to IN cord-010119-t1x9gknd 9482 32 4.0 4.0 CD cord-010119-t1x9gknd 9482 33 per per IN cord-010119-t1x9gknd 9482 34 1,000 1,000 CD cord-010119-t1x9gknd 9483 1 ( ( -LRB- cord-010119-t1x9gknd 9483 2 95 95 CD cord-010119-t1x9gknd 9483 3 % % NN cord-010119-t1x9gknd 9483 4 CI ci NN cord-010119-t1x9gknd 9483 5 : : : cord-010119-t1x9gknd 9483 6 3.7 3.7 CD cord-010119-t1x9gknd 9483 7 - - HYPH cord-010119-t1x9gknd 9483 8 4.3 4.3 CD cord-010119-t1x9gknd 9483 9 ) ) -RRB- cord-010119-t1x9gknd 9483 10 during during IN cord-010119-t1x9gknd 9483 11 1999 1999 CD cord-010119-t1x9gknd 9483 12 - - SYM cord-010119-t1x9gknd 9483 13 2016 2016 CD cord-010119-t1x9gknd 9483 14 , , , cord-010119-t1x9gknd 9483 15 and and CC cord-010119-t1x9gknd 9483 16 the the DT cord-010119-t1x9gknd 9483 17 agestandardized agestandardized JJ cord-010119-t1x9gknd 9483 18 prevalence prevalence NN cord-010119-t1x9gknd 9483 19 was be VBD cord-010119-t1x9gknd 9483 20 also also RB cord-010119-t1x9gknd 9483 21 decreased decrease VBN cord-010119-t1x9gknd 9483 22 from from IN cord-010119-t1x9gknd 9483 23 27.0 27.0 CD cord-010119-t1x9gknd 9483 24 per per IN cord-010119-t1x9gknd 9483 25 1,000 1,000 CD cord-010119-t1x9gknd 9483 26 donors donor NNS cord-010119-t1x9gknd 9483 27 ( ( -LRB- cord-010119-t1x9gknd 9483 28 95 95 CD cord-010119-t1x9gknd 9483 29 % % NN cord-010119-t1x9gknd 9483 30 CI ci NN cord-010119-t1x9gknd 9483 31 : : : cord-010119-t1x9gknd 9483 32 25.6 25.6 CD cord-010119-t1x9gknd 9483 33 - - HYPH cord-010119-t1x9gknd 9483 34 28.4 28.4 CD cord-010119-t1x9gknd 9483 35 ) ) -RRB- cord-010119-t1x9gknd 9483 36 to to IN cord-010119-t1x9gknd 9483 37 7.7 7.7 CD cord-010119-t1x9gknd 9483 38 per per IN cord-010119-t1x9gknd 9483 39 1,000 1,000 CD cord-010119-t1x9gknd 9483 40 ( ( -LRB- cord-010119-t1x9gknd 9483 41 95 95 CD cord-010119-t1x9gknd 9483 42 % % NN cord-010119-t1x9gknd 9483 43 CI ci NN cord-010119-t1x9gknd 9483 44 : : : cord-010119-t1x9gknd 9483 45 6.9 6.9 CD cord-010119-t1x9gknd 9483 46 - - SYM cord-010119-t1x9gknd 9483 47 8.5 8.5 CD cord-010119-t1x9gknd 9483 48 ) ) -RRB- cord-010119-t1x9gknd 9483 49 . . . cord-010119-t1x9gknd 9484 1 The the DT cord-010119-t1x9gknd 9484 2 agestandardized agestandardized JJ cord-010119-t1x9gknd 9484 3 prevalence prevalence NN cord-010119-t1x9gknd 9484 4 of of IN cord-010119-t1x9gknd 9484 5 anti anti JJ cord-010119-t1x9gknd 9484 6 - - NNP cord-010119-t1x9gknd 9484 7 HCV HCV NNP cord-010119-t1x9gknd 9484 8 was be VBD cord-010119-t1x9gknd 9484 9 generally generally RB cord-010119-t1x9gknd 9484 10 higher high JJR cord-010119-t1x9gknd 9484 11 in in IN cord-010119-t1x9gknd 9484 12 female female JJ cord-010119-t1x9gknd 9484 13 donors donor NNS cord-010119-t1x9gknd 9484 14 before before IN cord-010119-t1x9gknd 9484 15 2015 2015 CD cord-010119-t1x9gknd 9484 16 , , , cord-010119-t1x9gknd 9484 17 but but CC cord-010119-t1x9gknd 9484 18 it -PRON- PRP cord-010119-t1x9gknd 9484 19 was be VBD cord-010119-t1x9gknd 9484 20 significantly significantly RB cord-010119-t1x9gknd 9484 21 higher high JJR cord-010119-t1x9gknd 9484 22 in in IN cord-010119-t1x9gknd 9484 23 male male JJ cord-010119-t1x9gknd 9484 24 donors donor NNS cord-010119-t1x9gknd 9484 25 at at IN cord-010119-t1x9gknd 9484 26 2016 2016 CD cord-010119-t1x9gknd 9485 1 ( ( -LRB- cord-010119-t1x9gknd 9485 2 p p NN cord-010119-t1x9gknd 9485 3 - - HYPH cord-010119-t1x9gknd 9485 4 value50.03 value50.03 NNP cord-010119-t1x9gknd 9485 5 ) ) -RRB- cord-010119-t1x9gknd 9485 6 . . . cord-010119-t1x9gknd 9486 1 A a DT cord-010119-t1x9gknd 9486 2 total total NN cord-010119-t1x9gknd 9486 3 of of IN cord-010119-t1x9gknd 9486 4 1,036 1,036 CD cord-010119-t1x9gknd 9486 5 HCV HCV NNP cord-010119-t1x9gknd 9486 6 RNA RNA NNP cord-010119-t1x9gknd 9486 7 positive positive JJ cord-010119-t1x9gknd 9486 8 cases case NNS cord-010119-t1x9gknd 9486 9 , , , cord-010119-t1x9gknd 9486 10 1.9 1.9 CD cord-010119-t1x9gknd 9486 11 % % NN cord-010119-t1x9gknd 9486 12 of of IN cord-010119-t1x9gknd 9486 13 them -PRON- PRP cord-010119-t1x9gknd 9486 14 were be VBD cord-010119-t1x9gknd 9486 15 anti anti JJ cord-010119-t1x9gknd 9486 16 - - JJ cord-010119-t1x9gknd 9486 17 HCV HCV NNP cord-010119-t1x9gknd 9486 18 negative negative NN cord-010119-t1x9gknd 9486 19 , , , cord-010119-t1x9gknd 9486 20 identified identify VBN cord-010119-t1x9gknd 9486 21 from from IN cord-010119-t1x9gknd 9486 22 579,286 579,286 CD cord-010119-t1x9gknd 9486 23 first first JJ cord-010119-t1x9gknd 9486 24 - - HYPH cord-010119-t1x9gknd 9486 25 time time NN cord-010119-t1x9gknd 9486 26 donors donor NNS cord-010119-t1x9gknd 9486 27 during during IN cord-010119-t1x9gknd 9486 28 2013 2013 CD cord-010119-t1x9gknd 9486 29 - - SYM cord-010119-t1x9gknd 9486 30 2016 2016 CD cord-010119-t1x9gknd 9486 31 , , , cord-010119-t1x9gknd 9486 32 and and CC cord-010119-t1x9gknd 9486 33 the the DT cord-010119-t1x9gknd 9486 34 crude crude NN cord-010119-t1x9gknd 9486 35 and and CC cord-010119-t1x9gknd 9486 36 age age NN cord-010119-t1x9gknd 9486 37 - - HYPH cord-010119-t1x9gknd 9486 38 standardized standardize VBN cord-010119-t1x9gknd 9486 39 prevalence prevalence NN cord-010119-t1x9gknd 9486 40 of of IN cord-010119-t1x9gknd 9486 41 HCV HCV NNP cord-010119-t1x9gknd 9486 42 RNA RNA NNP cord-010119-t1x9gknd 9486 43 was be VBD cord-010119-t1x9gknd 9486 44 1.8 1.8 CD cord-010119-t1x9gknd 9486 45 per per IN cord-010119-t1x9gknd 9486 46 1,000 1,000 CD cord-010119-t1x9gknd 9487 1 ( ( -LRB- cord-010119-t1x9gknd 9487 2 95 95 CD cord-010119-t1x9gknd 9487 3 % % NN cord-010119-t1x9gknd 9487 4 CI ci NN cord-010119-t1x9gknd 9487 5 : : : cord-010119-t1x9gknd 9487 6 1.7 1.7 CD cord-010119-t1x9gknd 9487 7 - - SYM cord-010119-t1x9gknd 9487 8 1.9 1.9 CD cord-010119-t1x9gknd 9487 9 ) ) -RRB- cord-010119-t1x9gknd 9487 10 and and CC cord-010119-t1x9gknd 9487 11 5.0 5.0 CD cord-010119-t1x9gknd 9487 12 per per IN cord-010119-t1x9gknd 9487 13 1,000 1,000 CD cord-010119-t1x9gknd 9487 14 ( ( -LRB- cord-010119-t1x9gknd 9487 15 95 95 CD cord-010119-t1x9gknd 9487 16 % % NN cord-010119-t1x9gknd 9487 17 CI ci NN cord-010119-t1x9gknd 9487 18 : : : cord-010119-t1x9gknd 9487 19 4.3 4.3 CD cord-010119-t1x9gknd 9487 20 - - SYM cord-010119-t1x9gknd 9487 21 5.7 5.7 CD cord-010119-t1x9gknd 9487 22 ) ) -RRB- cord-010119-t1x9gknd 9487 23 , , , cord-010119-t1x9gknd 9487 24 respectively respectively RB cord-010119-t1x9gknd 9487 25 . . . cord-010119-t1x9gknd 9488 1 Crude crude JJ cord-010119-t1x9gknd 9488 2 prevalence prevalence NN cord-010119-t1x9gknd 9488 3 of of IN cord-010119-t1x9gknd 9488 4 HCV HCV NNP cord-010119-t1x9gknd 9488 5 RNA RNA NNP cord-010119-t1x9gknd 9488 6 was be VBD cord-010119-t1x9gknd 9488 7 significantly significantly RB cord-010119-t1x9gknd 9488 8 higher high JJR cord-010119-t1x9gknd 9488 9 in in IN cord-010119-t1x9gknd 9488 10 female female JJ cord-010119-t1x9gknd 9488 11 donors donor NNS cord-010119-t1x9gknd 9488 12 ( ( -LRB- cord-010119-t1x9gknd 9488 13 p p IN cord-010119-t1x9gknd 9488 14 value value NN cord-010119-t1x9gknd 9488 15 < < XX cord-010119-t1x9gknd 9488 16 0.0001 0.0001 CD cord-010119-t1x9gknd 9488 17 ) ) -RRB- cord-010119-t1x9gknd 9488 18 , , , cord-010119-t1x9gknd 9488 19 but but CC cord-010119-t1x9gknd 9488 20 no no DT cord-010119-t1x9gknd 9488 21 significant significant JJ cord-010119-t1x9gknd 9488 22 difference difference NN cord-010119-t1x9gknd 9488 23 was be VBD cord-010119-t1x9gknd 9488 24 found find VBN cord-010119-t1x9gknd 9488 25 after after IN cord-010119-t1x9gknd 9488 26 age age NN cord-010119-t1x9gknd 9488 27 standardization standardization NN cord-010119-t1x9gknd 9488 28 ( ( -LRB- cord-010119-t1x9gknd 9488 29 p p NN cord-010119-t1x9gknd 9488 30 value50.93 value50.93 NNP cord-010119-t1x9gknd 9488 31 ) ) -RRB- cord-010119-t1x9gknd 9488 32 . . . cord-010119-t1x9gknd 9489 1 Both both DT cord-010119-t1x9gknd 9489 2 the the DT cord-010119-t1x9gknd 9489 3 prevalence prevalence NN cord-010119-t1x9gknd 9489 4 of of IN cord-010119-t1x9gknd 9489 5 anti anti JJ cord-010119-t1x9gknd 9489 6 - - JJ cord-010119-t1x9gknd 9489 7 HCV HCV NNP cord-010119-t1x9gknd 9489 8 and and CC cord-010119-t1x9gknd 9489 9 HCV HCV NNP cord-010119-t1x9gknd 9489 10 RNA RNA NNP cord-010119-t1x9gknd 9489 11 were be VBD cord-010119-t1x9gknd 9489 12 increased increase VBN cord-010119-t1x9gknd 9489 13 with with IN cord-010119-t1x9gknd 9489 14 age age NN cord-010119-t1x9gknd 9489 15 ( ( -LRB- cord-010119-t1x9gknd 9489 16 p p NN cord-010119-t1x9gknd 9489 17 for for IN cord-010119-t1x9gknd 9489 18 trend<0.0001 trend<0.0001 NNP cord-010119-t1x9gknd 9489 19 ) ) -RRB- cord-010119-t1x9gknd 9489 20 . . . cord-010119-t1x9gknd 9490 1 In in IN cord-010119-t1x9gknd 9490 2 the the DT cord-010119-t1x9gknd 9490 3 incidence incidence NN cord-010119-t1x9gknd 9490 4 study study NN cord-010119-t1x9gknd 9490 5 , , , cord-010119-t1x9gknd 9490 6 a a DT cord-010119-t1x9gknd 9490 7 total total NN cord-010119-t1x9gknd 9490 8 of of IN cord-010119-t1x9gknd 9490 9 68 68 CD cord-010119-t1x9gknd 9490 10 new new JJ cord-010119-t1x9gknd 9490 11 HCV HCV NNP cord-010119-t1x9gknd 9490 12 RNA RNA NNP cord-010119-t1x9gknd 9490 13 positive positive JJ cord-010119-t1x9gknd 9490 14 cases case NNS cord-010119-t1x9gknd 9490 15 , , , cord-010119-t1x9gknd 9490 16 23.5 23.5 CD cord-010119-t1x9gknd 9490 17 % % NN cord-010119-t1x9gknd 9490 18 of of IN cord-010119-t1x9gknd 9490 19 them -PRON- PRP cord-010119-t1x9gknd 9490 20 were be VBD cord-010119-t1x9gknd 9490 21 anti anti JJ cord-010119-t1x9gknd 9490 22 - - JJ cord-010119-t1x9gknd 9490 23 HCV HCV NNP cord-010119-t1x9gknd 9490 24 negative negative NN cord-010119-t1x9gknd 9490 25 , , , cord-010119-t1x9gknd 9490 26 found find VBD cord-010119-t1x9gknd 9490 27 from from IN cord-010119-t1x9gknd 9490 28 1,202,165 1,202,165 CD cord-010119-t1x9gknd 9490 29 donors donor NNS cord-010119-t1x9gknd 9490 30 followed follow VBD cord-010119-t1x9gknd 9490 31 for for IN cord-010119-t1x9gknd 9490 32 2,415,668 2,415,668 CD cord-010119-t1x9gknd 9490 33 person person NN cord-010119-t1x9gknd 9490 34 - - HYPH cord-010119-t1x9gknd 9490 35 years year NNS cord-010119-t1x9gknd 9490 36 . . . cord-010119-t1x9gknd 9491 1 The the DT cord-010119-t1x9gknd 9491 2 incidence incidence NN cord-010119-t1x9gknd 9491 3 of of IN cord-010119-t1x9gknd 9491 4 HCV HCV NNP cord-010119-t1x9gknd 9491 5 RNA RNA NNP cord-010119-t1x9gknd 9491 6 was be VBD cord-010119-t1x9gknd 9491 7 2.8 2.8 CD cord-010119-t1x9gknd 9491 8 per per IN cord-010119-t1x9gknd 9491 9 100,000 100,000 CD cord-010119-t1x9gknd 9491 10 person person NN cord-010119-t1x9gknd 9491 11 - - HYPH cord-010119-t1x9gknd 9491 12 years year NNS cord-010119-t1x9gknd 9491 13 ( ( -LRB- cord-010119-t1x9gknd 9491 14 95 95 CD cord-010119-t1x9gknd 9491 15 % % NN cord-010119-t1x9gknd 9491 16 CI ci NN cord-010119-t1x9gknd 9491 17 : : : cord-010119-t1x9gknd 9491 18 2.2 2.2 CD cord-010119-t1x9gknd 9491 19 - - SYM cord-010119-t1x9gknd 9491 20 3.5 3.5 CD cord-010119-t1x9gknd 9491 21 ) ) -RRB- cord-010119-t1x9gknd 9491 22 , , , cord-010119-t1x9gknd 9491 23 and and CC cord-010119-t1x9gknd 9491 24 no no DT cord-010119-t1x9gknd 9491 25 significant significant JJ cord-010119-t1x9gknd 9491 26 difference difference NN cord-010119-t1x9gknd 9491 27 was be VBD cord-010119-t1x9gknd 9491 28 observed observe VBN cord-010119-t1x9gknd 9491 29 between between IN cord-010119-t1x9gknd 9491 30 both both DT cord-010119-t1x9gknd 9491 31 genders gender NNS cord-010119-t1x9gknd 9491 32 ( ( -LRB- cord-010119-t1x9gknd 9491 33 p p NN cord-010119-t1x9gknd 9491 34 - - HYPH cord-010119-t1x9gknd 9491 35 value50.41 value50.41 NN cord-010119-t1x9gknd 9491 36 ) ) -RRB- cord-010119-t1x9gknd 9491 37 and and CC cord-010119-t1x9gknd 9491 38 between between IN cord-010119-t1x9gknd 9491 39 age age NN cord-010119-t1x9gknd 9491 40 groups group NNS cord-010119-t1x9gknd 9491 41 ( ( -LRB- cord-010119-t1x9gknd 9491 42 p p NN cord-010119-t1x9gknd 9491 43 for for IN cord-010119-t1x9gknd 9491 44 trend trend NN cord-010119-t1x9gknd 9491 45 0.37 0.37 CD cord-010119-t1x9gknd 9491 46 ) ) -RRB- cord-010119-t1x9gknd 9491 47 . . . cord-010119-t1x9gknd 9492 1 Conclusion conclusion NN cord-010119-t1x9gknd 9492 2 : : : cord-010119-t1x9gknd 9493 1 The the DT cord-010119-t1x9gknd 9493 2 prevalence prevalence NN cord-010119-t1x9gknd 9493 3 of of IN cord-010119-t1x9gknd 9493 4 HCV HCV NNP cord-010119-t1x9gknd 9493 5 infection infection NN cord-010119-t1x9gknd 9493 6 has have VBZ cord-010119-t1x9gknd 9493 7 been be VBN cord-010119-t1x9gknd 9493 8 dramatically dramatically RB cord-010119-t1x9gknd 9493 9 decreased decrease VBN cord-010119-t1x9gknd 9493 10 by by IN cord-010119-t1x9gknd 9493 11 71.5 71.5 CD cord-010119-t1x9gknd 9493 12 % % NN cord-010119-t1x9gknd 9493 13 during during IN cord-010119-t1x9gknd 9493 14 1999 1999 CD cord-010119-t1x9gknd 9493 15 - - SYM cord-010119-t1x9gknd 9493 16 2013 2013 CD cord-010119-t1x9gknd 9493 17 . . . cord-010119-t1x9gknd 9494 1 It -PRON- PRP cord-010119-t1x9gknd 9494 2 becomes become VBZ cord-010119-t1x9gknd 9494 3 significantly significantly RB cord-010119-t1x9gknd 9494 4 higher high JJR cord-010119-t1x9gknd 9494 5 in in IN cord-010119-t1x9gknd 9494 6 male male JJ cord-010119-t1x9gknd 9494 7 donors donor NNS cord-010119-t1x9gknd 9494 8 and and CC cord-010119-t1x9gknd 9494 9 that that DT cord-010119-t1x9gknd 9494 10 needs need VBZ cord-010119-t1x9gknd 9494 11 to to TO cord-010119-t1x9gknd 9494 12 monitor monitor VB cord-010119-t1x9gknd 9494 13 in in IN cord-010119-t1x9gknd 9494 14 the the DT cord-010119-t1x9gknd 9494 15 future future NN cord-010119-t1x9gknd 9494 16 . . . cord-010119-t1x9gknd 9495 1 Incidence incidence NN cord-010119-t1x9gknd 9495 2 of of IN cord-010119-t1x9gknd 9495 3 HCV HCV NNP cord-010119-t1x9gknd 9495 4 RNA RNA NNP cord-010119-t1x9gknd 9495 5 is be VBZ cord-010119-t1x9gknd 9495 6 low low JJ cord-010119-t1x9gknd 9495 7 in in IN cord-010119-t1x9gknd 9495 8 repeat repeat NN cord-010119-t1x9gknd 9495 9 blood blood NN cord-010119-t1x9gknd 9495 10 donors donor NNS cord-010119-t1x9gknd 9495 11 and and CC cord-010119-t1x9gknd 9495 12 it -PRON- PRP cord-010119-t1x9gknd 9495 13 needs need VBZ cord-010119-t1x9gknd 9495 14 to to TO cord-010119-t1x9gknd 9495 15 identify identify VB cord-010119-t1x9gknd 9495 16 more more JJR cord-010119-t1x9gknd 9495 17 incident incident NN cord-010119-t1x9gknd 9495 18 cases case NNS cord-010119-t1x9gknd 9495 19 to to TO cord-010119-t1x9gknd 9495 20 observe observe VB cord-010119-t1x9gknd 9495 21 the the DT cord-010119-t1x9gknd 9495 22 epidemiological epidemiological JJ cord-010119-t1x9gknd 9495 23 characteristics characteristic NNS cord-010119-t1x9gknd 9495 24 . . . cord-010119-t1x9gknd 9496 1 Dalia Dalia NNP cord-010119-t1x9gknd 9496 2 Ashour Ashour NNP cord-010119-t1x9gknd 9496 3 * * NFP cord-010119-t1x9gknd 9496 4 1 1 CD cord-010119-t1x9gknd 9496 5 , , , cord-010119-t1x9gknd 9496 6 Sahar Sahar NNP cord-010119-t1x9gknd 9496 7 Muhmmad Muhmmad NNP cord-010119-t1x9gknd 9496 8 2 2 CD cord-010119-t1x9gknd 9496 9 and and CC cord-010119-t1x9gknd 9496 10 Dalia Dalia NNP cord-010119-t1x9gknd 9496 11 El El NNP cord-010119-t1x9gknd 9496 12 Dewi Dewi NNP cord-010119-t1x9gknd 9496 13 2 2 CD cord-010119-t1x9gknd 9496 14 . . . cord-010119-t1x9gknd 9497 1 1 1 LS cord-010119-t1x9gknd 9497 2 National National NNP cord-010119-t1x9gknd 9497 3 Blood Blood NNP cord-010119-t1x9gknd 9497 4 Transfusion Transfusion NNP cord-010119-t1x9gknd 9497 5 Services Services NNPS cord-010119-t1x9gknd 9497 6 , , , cord-010119-t1x9gknd 9497 7 2 2 CD cord-010119-t1x9gknd 9497 8 Azhar Azhar NNP cord-010119-t1x9gknd 9497 9 University University NNP cord-010119-t1x9gknd 9497 10 Background Background NNP cord-010119-t1x9gknd 9497 11 / / SYM cord-010119-t1x9gknd 9497 12 Case Case NNP cord-010119-t1x9gknd 9497 13 Studies Studies NNPS cord-010119-t1x9gknd 9497 14 : : : cord-010119-t1x9gknd 9498 1 Blood blood NN cord-010119-t1x9gknd 9498 2 safety safety NN cord-010119-t1x9gknd 9498 3 is be VBZ cord-010119-t1x9gknd 9498 4 a a DT cord-010119-t1x9gknd 9498 5 challenge challenge NN cord-010119-t1x9gknd 9498 6 in in IN cord-010119-t1x9gknd 9498 7 Egypt Egypt NNP cord-010119-t1x9gknd 9498 8 because because IN cord-010119-t1x9gknd 9498 9 of of IN cord-010119-t1x9gknd 9498 10 the the DT cord-010119-t1x9gknd 9498 11 high high JJ cord-010119-t1x9gknd 9498 12 prevalence prevalence NN cord-010119-t1x9gknd 9498 13 of of IN cord-010119-t1x9gknd 9498 14 HCV HCV NNP cord-010119-t1x9gknd 9498 15 and and CC cord-010119-t1x9gknd 9498 16 HBV HBV NNP cord-010119-t1x9gknd 9498 17 . . . cord-010119-t1x9gknd 9499 1 Nucleic nucleic JJ cord-010119-t1x9gknd 9499 2 acid acid NN cord-010119-t1x9gknd 9499 3 amplification amplification NN cord-010119-t1x9gknd 9499 4 test test NN cord-010119-t1x9gknd 9499 5 ( ( -LRB- cord-010119-t1x9gknd 9499 6 NAT NAT NNP cord-010119-t1x9gknd 9499 7 ) ) -RRB- cord-010119-t1x9gknd 9499 8 technologies technology NNS cord-010119-t1x9gknd 9499 9 have have VBP cord-010119-t1x9gknd 9499 10 the the DT cord-010119-t1x9gknd 9499 11 potential potential NN cord-010119-t1x9gknd 9499 12 to to TO cord-010119-t1x9gknd 9499 13 detect detect VB cord-010119-t1x9gknd 9499 14 viremia viremia NN cord-010119-t1x9gknd 9499 15 earlier early RBR cord-010119-t1x9gknd 9499 16 than than IN cord-010119-t1x9gknd 9499 17 current current JJ cord-010119-t1x9gknd 9499 18 screening screening NN cord-010119-t1x9gknd 9499 19 methods method NNS cord-010119-t1x9gknd 9499 20 , , , cord-010119-t1x9gknd 9499 21 which which WDT cord-010119-t1x9gknd 9499 22 are be VBP cord-010119-t1x9gknd 9499 23 based base VBN cord-010119-t1x9gknd 9499 24 on on IN cord-010119-t1x9gknd 9499 25 seroconversion seroconversion NN cord-010119-t1x9gknd 9499 26 . . . cord-010119-t1x9gknd 9500 1 The the DT cord-010119-t1x9gknd 9500 2 primary primary JJ cord-010119-t1x9gknd 9500 3 benefit benefit NN cord-010119-t1x9gknd 9500 4 of of IN cord-010119-t1x9gknd 9500 5 NAT NAT NNP cord-010119-t1x9gknd 9500 6 is be VBZ cord-010119-t1x9gknd 9500 7 the the DT cord-010119-t1x9gknd 9500 8 ability ability NN cord-010119-t1x9gknd 9500 9 to to TO cord-010119-t1x9gknd 9500 10 reduce reduce VB cord-010119-t1x9gknd 9500 11 residual residual JJ cord-010119-t1x9gknd 9500 12 risk risk NN cord-010119-t1x9gknd 9500 13 of of IN cord-010119-t1x9gknd 9500 14 infectious infectious JJ cord-010119-t1x9gknd 9500 15 WP WP NNP cord-010119-t1x9gknd 9500 16 donations donation NNS cord-010119-t1x9gknd 9500 17 . . . cord-010119-t1x9gknd 9501 1 The the DT cord-010119-t1x9gknd 9501 2 estimated estimate VBN cord-010119-t1x9gknd 9501 3 reduction reduction NN cord-010119-t1x9gknd 9501 4 of of IN cord-010119-t1x9gknd 9501 5 the the DT cord-010119-t1x9gknd 9501 6 WP WP NNP cord-010119-t1x9gknd 9501 7 utilizing utilize VBG cord-010119-t1x9gknd 9501 8 NAT NAT NNP cord-010119-t1x9gknd 9501 9 for for IN cord-010119-t1x9gknd 9501 10 HCV HCV NNP cord-010119-t1x9gknd 9501 11 is be VBZ cord-010119-t1x9gknd 9501 12 70 70 CD cord-010119-t1x9gknd 9501 13 - - SYM cord-010119-t1x9gknd 9501 14 12 12 CD cord-010119-t1x9gknd 9501 15 days day NNS cord-010119-t1x9gknd 9501 16 , , , cord-010119-t1x9gknd 9501 17 HIV HIV NNP cord-010119-t1x9gknd 9501 18 from from IN cord-010119-t1x9gknd 9501 19 22 22 CD cord-010119-t1x9gknd 9501 20 to to TO cord-010119-t1x9gknd 9501 21 11 11 CD cord-010119-t1x9gknd 9501 22 days day NNS cord-010119-t1x9gknd 9501 23 , , , cord-010119-t1x9gknd 9501 24 and and CC cord-010119-t1x9gknd 9501 25 HBV HBV NNP cord-010119-t1x9gknd 9501 26 from from IN cord-010119-t1x9gknd 9501 27 25 25 CD cord-010119-t1x9gknd 9501 28 - - SYM cord-010119-t1x9gknd 9501 29 30 30 CD cord-010119-t1x9gknd 9501 30 days day NNS cord-010119-t1x9gknd 9501 31 . . . cord-010119-t1x9gknd 9502 1 Study Study NNP cord-010119-t1x9gknd 9502 2 Design Design NNP cord-010119-t1x9gknd 9502 3 / / SYM cord-010119-t1x9gknd 9502 4 Method method NN cord-010119-t1x9gknd 9502 5 : : : cord-010119-t1x9gknd 9503 1 This this DT cord-010119-t1x9gknd 9503 2 cross cross JJ cord-010119-t1x9gknd 9503 3 sectional sectional JJ cord-010119-t1x9gknd 9503 4 study study NN cord-010119-t1x9gknd 9503 5 was be VBD cord-010119-t1x9gknd 9503 6 conducted conduct VBN cord-010119-t1x9gknd 9503 7 in in IN cord-010119-t1x9gknd 9503 8 National National NNP cord-010119-t1x9gknd 9503 9 blood blood NN cord-010119-t1x9gknd 9503 10 Transfusion Transfusion NNP cord-010119-t1x9gknd 9503 11 Center Center NNP cord-010119-t1x9gknd 9503 12 ( ( -LRB- cord-010119-t1x9gknd 9503 13 Giza Giza NNP cord-010119-t1x9gknd 9503 14 , , , cord-010119-t1x9gknd 9503 15 Egypt Egypt NNP cord-010119-t1x9gknd 9503 16 ) ) -RRB- cord-010119-t1x9gknd 9503 17 from from IN cord-010119-t1x9gknd 9503 18 2012 2012 CD cord-010119-t1x9gknd 9503 19 to to IN cord-010119-t1x9gknd 9503 20 2015 2015 CD cord-010119-t1x9gknd 9504 1 , , , cord-010119-t1x9gknd 9504 2 The the DT cord-010119-t1x9gknd 9504 3 total total JJ cord-010119-t1x9gknd 9504 4 number number NN cord-010119-t1x9gknd 9504 5 of of IN cord-010119-t1x9gknd 9504 6 donor donor NN cord-010119-t1x9gknd 9504 7 samples sample NNS cord-010119-t1x9gknd 9504 8 to to TO cord-010119-t1x9gknd 9504 9 be be VB cord-010119-t1x9gknd 9504 10 screened screen VBN cord-010119-t1x9gknd 9504 11 is be VBZ cord-010119-t1x9gknd 9504 12 178685 178685 CD cord-010119-t1x9gknd 9504 13 , , , cord-010119-t1x9gknd 9504 14 The the DT cord-010119-t1x9gknd 9504 15 age age NN cord-010119-t1x9gknd 9504 16 of of IN cord-010119-t1x9gknd 9504 17 the the DT cord-010119-t1x9gknd 9504 18 donors donor NNS cord-010119-t1x9gknd 9504 19 ranged range VBD cord-010119-t1x9gknd 9504 20 from from IN cord-010119-t1x9gknd 9504 21 18 18 CD cord-010119-t1x9gknd 9504 22 to to TO cord-010119-t1x9gknd 9504 23 50 50 CD cord-010119-t1x9gknd 9504 24 years year NNS cord-010119-t1x9gknd 9504 25 , , , cord-010119-t1x9gknd 9504 26 and and CC cord-010119-t1x9gknd 9504 27 they -PRON- PRP cord-010119-t1x9gknd 9504 28 were be VBD cord-010119-t1x9gknd 9504 29 of of IN cord-010119-t1x9gknd 9504 30 both both DT cord-010119-t1x9gknd 9504 31 sexes sex NNS cord-010119-t1x9gknd 9505 1 ( ( -LRB- cord-010119-t1x9gknd 9505 2 M m NN cord-010119-t1x9gknd 9505 3 : : : cord-010119-t1x9gknd 9505 4 F F NNP cord-010119-t1x9gknd 9505 5 5 5 CD cord-010119-t1x9gknd 9505 6 3:1).Screening 3:1).screene VBG cord-010119-t1x9gknd 9505 7 by by IN cord-010119-t1x9gknd 9505 8 NAT NAT NNP cord-010119-t1x9gknd 9505 9 Ulterio Ulterio NNP cord-010119-t1x9gknd 9505 10 assay assay NN cord-010119-t1x9gknd 9505 11 ( ( -LRB- cord-010119-t1x9gknd 9505 12 Grifols Grifols NNP cord-010119-t1x9gknd 9505 13 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 9505 14 ; ; : cord-010119-t1x9gknd 9505 15 formerly formerly RB cord-010119-t1x9gknd 9505 16 Novartis Novartis NNP cord-010119-t1x9gknd 9505 17 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9505 18 ) ) -RRB- cord-010119-t1x9gknd 9505 19 was be VBD cord-010119-t1x9gknd 9505 20 done do VBN cord-010119-t1x9gknd 9505 21 in in IN cord-010119-t1x9gknd 9505 22 parallel parallel NN cord-010119-t1x9gknd 9505 23 with with IN cord-010119-t1x9gknd 9505 24 EIA EIA NNP cord-010119-t1x9gknd 9505 25 testing testing NN cord-010119-t1x9gknd 9505 26 for for IN cord-010119-t1x9gknd 9505 27 HBsAg hbsag ADD cord-010119-t1x9gknd 9505 28 , , , cord-010119-t1x9gknd 9505 29 HCV HCV NNP cord-010119-t1x9gknd 9505 30 - - HYPH cord-010119-t1x9gknd 9505 31 Ab Ab NNP cord-010119-t1x9gknd 9505 32 and and CC cord-010119-t1x9gknd 9505 33 HIV HIV NNP cord-010119-t1x9gknd 9506 1 Ag/ Ag/ NNP cord-010119-t1x9gknd 9506 2 Ab Ab NNP cord-010119-t1x9gknd 9506 3 . . . cord-010119-t1x9gknd 9507 1 using use VBG cord-010119-t1x9gknd 9507 2 individual individual JJ cord-010119-t1x9gknd 9507 3 donation donation NN cord-010119-t1x9gknd 9507 4 NAT NAT NNP cord-010119-t1x9gknd 9507 5 ( ( -LRB- cord-010119-t1x9gknd 9507 6 ID ID NNP cord-010119-t1x9gknd 9507 7 - - HYPH cord-010119-t1x9gknd 9507 8 NAT NAT NNP cord-010119-t1x9gknd 9507 9 ) ) -RRB- cord-010119-t1x9gknd 9507 10 . . . cord-010119-t1x9gknd 9508 1 Multiplex multiplex JJ cord-010119-t1x9gknd 9508 2 NAT NAT NNP cord-010119-t1x9gknd 9508 3 yield yield NN cord-010119-t1x9gknd 9508 4 samples sample NNS cord-010119-t1x9gknd 9508 5 are be VBP cord-010119-t1x9gknd 9508 6 further further RB cord-010119-t1x9gknd 9508 7 tested test VBN cord-010119-t1x9gknd 9508 8 using use VBG cord-010119-t1x9gknd 9508 9 the the DT cord-010119-t1x9gknd 9508 10 discriminatory discriminatory JJ cord-010119-t1x9gknd 9508 11 assay assay NN cord-010119-t1x9gknd 9508 12 in in IN cord-010119-t1x9gknd 9508 13 order order NN cord-010119-t1x9gknd 9508 14 to to TO cord-010119-t1x9gknd 9508 15 ascertain ascertain VB cord-010119-t1x9gknd 9508 16 which which WDT cord-010119-t1x9gknd 9508 17 viral viral JJ cord-010119-t1x9gknd 9508 18 nucleic nucleic JJ cord-010119-t1x9gknd 9508 19 acid acid NN cord-010119-t1x9gknd 9508 20 is be VBZ cord-010119-t1x9gknd 9508 21 present present JJ cord-010119-t1x9gknd 9508 22 in in IN cord-010119-t1x9gknd 9508 23 the the DT cord-010119-t1x9gknd 9508 24 donor donor NN cord-010119-t1x9gknd 9508 25 sample sample NN cord-010119-t1x9gknd 9508 26 . . . cord-010119-t1x9gknd 9509 1 Statistical statistical JJ cord-010119-t1x9gknd 9509 2 analysis analysis NN cord-010119-t1x9gknd 9510 1 Chi Chi NNP cord-010119-t1x9gknd 9510 2 - - HYPH cord-010119-t1x9gknd 9510 3 square square NNP cord-010119-t1x9gknd 9510 4 ( ( -LRB- cord-010119-t1x9gknd 9510 5 v2 v2 NN cord-010119-t1x9gknd 9510 6 ) ) -RRB- cord-010119-t1x9gknd 9510 7 test test NN cord-010119-t1x9gknd 9510 8 was be VBD cord-010119-t1x9gknd 9510 9 used use VBN cord-010119-t1x9gknd 9510 10 to to TO cord-010119-t1x9gknd 9510 11 measure measure VB cord-010119-t1x9gknd 9510 12 the the DT cord-010119-t1x9gknd 9510 13 association association NN cord-010119-t1x9gknd 9510 14 between between IN cord-010119-t1x9gknd 9510 15 two two CD cord-010119-t1x9gknd 9510 16 qualitative qualitative JJ cord-010119-t1x9gknd 9510 17 variables variable NNS cord-010119-t1x9gknd 9510 18 . . . cord-010119-t1x9gknd 9511 1 Results/ Results/ . cord-010119-t1x9gknd 9512 1 Finding finding NN cord-010119-t1x9gknd 9512 2 : : : cord-010119-t1x9gknd 9513 1 NAT NAT NNP cord-010119-t1x9gknd 9513 2 screening screening NN cord-010119-t1x9gknd 9513 3 detected detect VBD cord-010119-t1x9gknd 9513 4 a a DT cord-010119-t1x9gknd 9513 5 total total NN cord-010119-t1x9gknd 9513 6 of of IN cord-010119-t1x9gknd 9513 7 75 75 CD cord-010119-t1x9gknd 9513 8 NAT NAT NNP cord-010119-t1x9gknd 9513 9 yield yield NN cord-010119-t1x9gknd 9513 10 donations donation NNS cord-010119-t1x9gknd 9513 11 among among IN cord-010119-t1x9gknd 9513 12 178685 178685 CD cord-010119-t1x9gknd 9513 13 ( ( -LRB- cord-010119-t1x9gknd 9513 14 0.04 0.04 CD cord-010119-t1x9gknd 9513 15 % % NN cord-010119-t1x9gknd 9513 16 ) ) -RRB- cord-010119-t1x9gknd 9513 17 seronegative seronegative JJ cord-010119-t1x9gknd 9513 18 donors donor NNS cord-010119-t1x9gknd 9513 19 . . . cord-010119-t1x9gknd 9514 1 Among among IN cord-010119-t1x9gknd 9514 2 these these DT cord-010119-t1x9gknd 9514 3 75 75 CD cord-010119-t1x9gknd 9514 4 NAT NAT NNP cord-010119-t1x9gknd 9514 5 yields yield NNS cord-010119-t1x9gknd 9514 6 cases case NNS cord-010119-t1x9gknd 9514 7 , , , cord-010119-t1x9gknd 9514 8 53 53 CD cord-010119-t1x9gknd 9514 9 ( ( -LRB- cord-010119-t1x9gknd 9514 10 0.03 0.03 CD cord-010119-t1x9gknd 9514 11 % % NN cord-010119-t1x9gknd 9514 12 ) ) -RRB- cord-010119-t1x9gknd 9514 13 were be VBD cord-010119-t1x9gknd 9514 14 reactive reactive JJ cord-010119-t1x9gknd 9514 15 for for IN cord-010119-t1x9gknd 9514 16 HBV HBV NNP cord-010119-t1x9gknd 9514 17 , , , cord-010119-t1x9gknd 9514 18 20 20 CD cord-010119-t1x9gknd 9514 19 ( ( -LRB- cord-010119-t1x9gknd 9514 20 0.011 0.011 CD cord-010119-t1x9gknd 9514 21 % % NN cord-010119-t1x9gknd 9514 22 ) ) -RRB- cord-010119-t1x9gknd 9514 23 were be VBD cord-010119-t1x9gknd 9514 24 reactive reactive JJ cord-010119-t1x9gknd 9514 25 for for IN cord-010119-t1x9gknd 9514 26 HCV HCV NNP cord-010119-t1x9gknd 9514 27 and and CC cord-010119-t1x9gknd 9514 28 2 2 CD cord-010119-t1x9gknd 9514 29 ( ( -LRB- cord-010119-t1x9gknd 9514 30 0.001 0.001 CD cord-010119-t1x9gknd 9514 31 % % NN cord-010119-t1x9gknd 9514 32 ) ) -RRB- cord-010119-t1x9gknd 9514 33 were be VBD cord-010119-t1x9gknd 9514 34 reactive reactive JJ cord-010119-t1x9gknd 9514 35 for for IN cord-010119-t1x9gknd 9514 36 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9514 37 . . . cord-010119-t1x9gknd 9515 1 We -PRON- PRP cord-010119-t1x9gknd 9515 2 stratified stratify VBD cord-010119-t1x9gknd 9515 3 the the DT cord-010119-t1x9gknd 9515 4 age age NN cord-010119-t1x9gknd 9515 5 of of IN cord-010119-t1x9gknd 9515 6 the the DT cord-010119-t1x9gknd 9515 7 donors donor NNS cord-010119-t1x9gknd 9515 8 into into IN cord-010119-t1x9gknd 9515 9 3 3 CD cord-010119-t1x9gknd 9515 10 groups group NNS cord-010119-t1x9gknd 9515 11 ; ; : cord-010119-t1x9gknd 9515 12 group group NN cord-010119-t1x9gknd 9515 13 A A NNP cord-010119-t1x9gknd 9515 14 ( ( -LRB- cord-010119-t1x9gknd 9515 15 18 18 CD cord-010119-t1x9gknd 9515 16 -28 -28 NN cord-010119-t1x9gknd 9515 17 years year NNS cord-010119-t1x9gknd 9515 18 ) ) -RRB- cord-010119-t1x9gknd 9515 19 , , , cord-010119-t1x9gknd 9515 20 group group NN cord-010119-t1x9gknd 9515 21 B B NNP cord-010119-t1x9gknd 9515 22 ( ( -LRB- cord-010119-t1x9gknd 9515 23 29 29 CD cord-010119-t1x9gknd 9515 24 -39 -39 CD cord-010119-t1x9gknd 9515 25 years year NNS cord-010119-t1x9gknd 9515 26 ) ) -RRB- cord-010119-t1x9gknd 9515 27 and and CC cord-010119-t1x9gknd 9515 28 group group NN cord-010119-t1x9gknd 9515 29 C C NNP cord-010119-t1x9gknd 9515 30 ( ( -LRB- cord-010119-t1x9gknd 9515 31 40 40 CD cord-010119-t1x9gknd 9515 32 -50 -50 NN cord-010119-t1x9gknd 9515 33 years year NNS cord-010119-t1x9gknd 9515 34 ) ) -RRB- cord-010119-t1x9gknd 9515 35 . . . cord-010119-t1x9gknd 9516 1 The the DT cord-010119-t1x9gknd 9516 2 prevalence prevalence NN cord-010119-t1x9gknd 9516 3 of of IN cord-010119-t1x9gknd 9516 4 NAT NAT NNP cord-010119-t1x9gknd 9516 5 yield yield NN cord-010119-t1x9gknd 9516 6 to to IN cord-010119-t1x9gknd 9516 7 the the DT cord-010119-t1x9gknd 9516 8 three three CD cord-010119-t1x9gknd 9516 9 viruses virus NNS cord-010119-t1x9gknd 9516 10 was be VBD cord-010119-t1x9gknd 9516 11 significantly significantly RB cord-010119-t1x9gknd 9516 12 higher high JJR cord-010119-t1x9gknd 9516 13 in in IN cord-010119-t1x9gknd 9516 14 either either DT cord-010119-t1x9gknd 9516 15 group group NN cord-010119-t1x9gknd 9516 16 B b NN cord-010119-t1x9gknd 9516 17 or or CC cord-010119-t1x9gknd 9516 18 C C NNP cord-010119-t1x9gknd 9516 19 , , , cord-010119-t1x9gknd 9516 20 compared compare VBN cord-010119-t1x9gknd 9516 21 to to IN cord-010119-t1x9gknd 9516 22 group group NN cord-010119-t1x9gknd 9516 23 A a NN cord-010119-t1x9gknd 9516 24 ( ( -LRB- cord-010119-t1x9gknd 9516 25 p p NN cord-010119-t1x9gknd 9516 26 5 5 CD cord-010119-t1x9gknd 9516 27 0.0089 0.0089 CD cord-010119-t1x9gknd 9516 28 ; ; : cord-010119-t1x9gknd 9516 29 with with IN cord-010119-t1x9gknd 9516 30 95 95 CD cord-010119-t1x9gknd 9516 31 % % NN cord-010119-t1x9gknd 9516 32 confidence confidence NN cord-010119-t1x9gknd 9516 33 interval interval NN cord-010119-t1x9gknd 9516 34 ( ( -LRB- cord-010119-t1x9gknd 9516 35 CI CI NNP cord-010119-t1x9gknd 9516 36 ) ) -RRB- cord-010119-t1x9gknd 9516 37 5 5 CD cord-010119-t1x9gknd 9516 38 0.0085 0.0085 CD cord-010119-t1x9gknd 9516 39 -0.0520 -0.0520 NNS cord-010119-t1x9gknd 9516 40 & & CC cord-010119-t1x9gknd 9516 41 p p NN cord-010119-t1x9gknd 9516 42 5 5 CD cord-010119-t1x9gknd 9516 43 0.0247 0.0247 CD cord-010119-t1x9gknd 9516 44 ; ; : cord-010119-t1x9gknd 9516 45 with with IN cord-010119-t1x9gknd 9516 46 95 95 CD cord-010119-t1x9gknd 9516 47 % % NN cord-010119-t1x9gknd 9516 48 CI ci NN cord-010119-t1x9gknd 9516 49 5 5 CD cord-010119-t1x9gknd 9516 50 0.0025 0.0025 CD cord-010119-t1x9gknd 9516 51 -0.0534 -0.0534 : cord-010119-t1x9gknd 9516 52 respectively respectively RB cord-010119-t1x9gknd 9516 53 ) ) -RRB- cord-010119-t1x9gknd 9516 54 . . . cord-010119-t1x9gknd 9517 1 Prevalence prevalence NN cord-010119-t1x9gknd 9517 2 of of IN cord-010119-t1x9gknd 9517 3 NAT NAT NNP cord-010119-t1x9gknd 9517 4 - - HYPH cord-010119-t1x9gknd 9517 5 HBV HBV NNP cord-010119-t1x9gknd 9517 6 ; ; : cord-010119-t1x9gknd 9517 7 was be VBD cord-010119-t1x9gknd 9517 8 significantly significantly RB cord-010119-t1x9gknd 9517 9 higher high JJR cord-010119-t1x9gknd 9517 10 in in IN cord-010119-t1x9gknd 9517 11 age age NN cord-010119-t1x9gknd 9517 12 group group NN cord-010119-t1x9gknd 9517 13 B B NNP cord-010119-t1x9gknd 9517 14 , , , cord-010119-t1x9gknd 9517 15 as as IN cord-010119-t1x9gknd 9517 16 compared compare VBN cord-010119-t1x9gknd 9517 17 with with IN cord-010119-t1x9gknd 9517 18 group group NN cord-010119-t1x9gknd 9517 19 A a NN cord-010119-t1x9gknd 9517 20 ( ( -LRB- cord-010119-t1x9gknd 9517 21 p p NN cord-010119-t1x9gknd 9517 22 5 5 CD cord-010119-t1x9gknd 9517 23 0.0224 0.0224 CD cord-010119-t1x9gknd 9517 24 ; ; : cord-010119-t1x9gknd 9517 25 with with IN cord-010119-t1x9gknd 9517 26 95 95 CD cord-010119-t1x9gknd 9517 27 % % NN cord-010119-t1x9gknd 9517 28 CI CI NNP cord-010119-t1x9gknd 9517 29 5 5 CD cord-010119-t1x9gknd 9517 30 0.0032 0.0032 CD cord-010119-t1x9gknd 9517 31 -0.0413 -0.0413 NN cord-010119-t1x9gknd 9517 32 ) ) -RRB- cord-010119-t1x9gknd 9517 33 . . . cord-010119-t1x9gknd 9518 1 On on IN cord-010119-t1x9gknd 9518 2 the the DT cord-010119-t1x9gknd 9518 3 other other JJ cord-010119-t1x9gknd 9518 4 hand hand NN cord-010119-t1x9gknd 9518 5 , , , cord-010119-t1x9gknd 9518 6 there there EX cord-010119-t1x9gknd 9518 7 was be VBD cord-010119-t1x9gknd 9518 8 no no DT cord-010119-t1x9gknd 9518 9 statistically statistically RB cord-010119-t1x9gknd 9518 10 significant significant JJ cord-010119-t1x9gknd 9518 11 difference difference NN cord-010119-t1x9gknd 9518 12 between between IN cord-010119-t1x9gknd 9518 13 groups group NNS cord-010119-t1x9gknd 9518 14 C C NNP cord-010119-t1x9gknd 9518 15 and and CC cord-010119-t1x9gknd 9518 16 A A NNP cord-010119-t1x9gknd 9518 17 and and CC cord-010119-t1x9gknd 9518 18 between between IN cord-010119-t1x9gknd 9518 19 groups group NNS cord-010119-t1x9gknd 9518 20 B b NN cord-010119-t1x9gknd 9518 21 and and CC cord-010119-t1x9gknd 9518 22 C. C. NNP cord-010119-t1x9gknd 9518 23 Comparing compare VBG cord-010119-t1x9gknd 9518 24 groups group NNS cord-010119-t1x9gknd 9518 25 B B NNP cord-010119-t1x9gknd 9518 26 and and CC cord-010119-t1x9gknd 9518 27 C c NN cord-010119-t1x9gknd 9518 28 combined combine VBN cord-010119-t1x9gknd 9518 29 with with IN cord-010119-t1x9gknd 9518 30 group group NN cord-010119-t1x9gknd 9518 31 A A NNP cord-010119-t1x9gknd 9518 32 found find VBD cord-010119-t1x9gknd 9518 33 a a DT cord-010119-t1x9gknd 9518 34 significantly significantly RB cord-010119-t1x9gknd 9518 35 higher high JJR cord-010119-t1x9gknd 9518 36 prevalence prevalence NN cord-010119-t1x9gknd 9518 37 of of IN cord-010119-t1x9gknd 9518 38 HBV HBV NNP cord-010119-t1x9gknd 9518 39 in in IN cord-010119-t1x9gknd 9518 40 the the DT cord-010119-t1x9gknd 9518 41 former former JJ cord-010119-t1x9gknd 9518 42 ( ( -LRB- cord-010119-t1x9gknd 9518 43 p p NN cord-010119-t1x9gknd 9518 44 5 5 CD cord-010119-t1x9gknd 9518 45 0.0335 0.0335 CD cord-010119-t1x9gknd 9518 46 ; ; : cord-010119-t1x9gknd 9518 47 with with IN cord-010119-t1x9gknd 9518 48 95 95 CD cord-010119-t1x9gknd 9518 49 % % NN cord-010119-t1x9gknd 9518 50 CI ci NN cord-010119-t1x9gknd 9518 51 5 5 CD cord-010119-t1x9gknd 9518 52 0.0015 0.0015 CD cord-010119-t1x9gknd 9518 53 -0.0352 -0.0352 CD cord-010119-t1x9gknd 9518 54 ) ) -RRB- cord-010119-t1x9gknd 9518 55 . . . cord-010119-t1x9gknd 9519 1 NAT NAT NNP cord-010119-t1x9gknd 9519 2 - - HYPH cord-010119-t1x9gknd 9519 3 HCV HCV NNP cord-010119-t1x9gknd 9519 4 ; ; : cord-010119-t1x9gknd 9519 5 did do VBD cord-010119-t1x9gknd 9519 6 not not RB cord-010119-t1x9gknd 9519 7 differ differ VB cord-010119-t1x9gknd 9519 8 significantly significantly RB cord-010119-t1x9gknd 9519 9 between between IN cord-010119-t1x9gknd 9519 10 the the DT cord-010119-t1x9gknd 9519 11 three three CD cord-010119-t1x9gknd 9519 12 groups group NNS cord-010119-t1x9gknd 9519 13 ( ( -LRB- cord-010119-t1x9gknd 9519 14 p p NN cord-010119-t1x9gknd 9519 15 5 5 CD cord-010119-t1x9gknd 9519 16 0.3222 0.3222 CD cord-010119-t1x9gknd 9519 17 ; ; : cord-010119-t1x9gknd 9519 18 with with IN cord-010119-t1x9gknd 9519 19 95 95 CD cord-010119-t1x9gknd 9519 20 % % NN cord-010119-t1x9gknd 9519 21 CI CI NNP cord-010119-t1x9gknd 9519 22 5 5 CD cord-010119-t1x9gknd 9519 23 - - SYM cord-010119-t1x9gknd 9519 24 0.0089 0.0089 CD cord-010119-t1x9gknd 9519 25 to to IN cord-010119-t1x9gknd 9519 26 0.0161 0.0161 CD cord-010119-t1x9gknd 9519 27 between between IN cord-010119-t1x9gknd 9519 28 groups group NNS cord-010119-t1x9gknd 9519 29 A A NNP cord-010119-t1x9gknd 9519 30 and and CC cord-010119-t1x9gknd 9519 31 B b NN cord-010119-t1x9gknd 9519 32 & & CC cord-010119-t1x9gknd 9519 33 p p NN cord-010119-t1x9gknd 9519 34 5 5 CD cord-010119-t1x9gknd 9519 35 0.1340 0.1340 CD cord-010119-t1x9gknd 9519 36 ; ; : cord-010119-t1x9gknd 9519 37 with with IN cord-010119-t1x9gknd 9519 38 95 95 CD cord-010119-t1x9gknd 9519 39 % % NN cord-010119-t1x9gknd 9519 40 CI CI NNP cord-010119-t1x9gknd 9519 41 5 5 CD cord-010119-t1x9gknd 9519 42 -0.0055 -0.0055 NN cord-010119-t1x9gknd 9519 43 to to IN cord-010119-t1x9gknd 9519 44 0.0270 0.0270 CD cord-010119-t1x9gknd 9519 45 between between IN cord-010119-t1x9gknd 9519 46 groups group NNS cord-010119-t1x9gknd 9519 47 A A NNP cord-010119-t1x9gknd 9519 48 and and CC cord-010119-t1x9gknd 9519 49 C C NNP cord-010119-t1x9gknd 9519 50 & & CC cord-010119-t1x9gknd 9519 51 p p NNP cord-010119-t1x9gknd 9519 52 5 5 CD cord-010119-t1x9gknd 9519 53 0.4277 0.4277 CD cord-010119-t1x9gknd 9519 54 ; ; : cord-010119-t1x9gknd 9519 55 with with IN cord-010119-t1x9gknd 9519 56 95 95 CD cord-010119-t1x9gknd 9519 57 % % NN cord-010119-t1x9gknd 9519 58 CI CI NNP cord-010119-t1x9gknd 9519 59 5 5 CD cord-010119-t1x9gknd 9519 60 -0.0080 -0.0080 JJR cord-010119-t1x9gknd 9519 61 to to IN cord-010119-t1x9gknd 9519 62 0.0215 0.0215 CD cord-010119-t1x9gknd 9519 63 between between IN cord-010119-t1x9gknd 9519 64 groups group NNS cord-010119-t1x9gknd 9519 65 B b NN cord-010119-t1x9gknd 9519 66 and and CC cord-010119-t1x9gknd 9519 67 C C NNP cord-010119-t1x9gknd 9519 68 ) ) -RRB- cord-010119-t1x9gknd 9519 69 . . . cord-010119-t1x9gknd 9520 1 NAT NAT NNP cord-010119-t1x9gknd 9520 2 - - HYPH cord-010119-t1x9gknd 9520 3 HIV HIV NNP cord-010119-t1x9gknd 9520 4 ; ; : cord-010119-t1x9gknd 9520 5 did do VBD cord-010119-t1x9gknd 9520 6 not not RB cord-010119-t1x9gknd 9520 7 also also RB cord-010119-t1x9gknd 9520 8 differ differ VB cord-010119-t1x9gknd 9520 9 significantly significantly RB cord-010119-t1x9gknd 9520 10 between between IN cord-010119-t1x9gknd 9520 11 the the DT cord-010119-t1x9gknd 9520 12 three three CD cord-010119-t1x9gknd 9520 13 groups group NNS cord-010119-t1x9gknd 9520 14 ( ( -LRB- cord-010119-t1x9gknd 9520 15 p p NN cord-010119-t1x9gknd 9520 16 5 5 CD cord-010119-t1x9gknd 9520 17 0.3801 0.3801 CD cord-010119-t1x9gknd 9520 18 ; ; : cord-010119-t1x9gknd 9520 19 with with IN cord-010119-t1x9gknd 9520 20 95 95 CD cord-010119-t1x9gknd 9520 21 % % NN cord-010119-t1x9gknd 9520 22 CI CI NNP cord-010119-t1x9gknd 9520 23 5 5 CD cord-010119-t1x9gknd 9520 24 - - SYM cord-010119-t1x9gknd 9520 25 0.0077 0.0077 CD cord-010119-t1x9gknd 9520 26 to to TO cord-010119-t1x9gknd 9520 27 0.0077 0.0077 CD cord-010119-t1x9gknd 9520 28 between between IN cord-010119-t1x9gknd 9520 29 groups group NNS cord-010119-t1x9gknd 9520 30 A A NNP cord-010119-t1x9gknd 9520 31 and and CC cord-010119-t1x9gknd 9520 32 B b NN cord-010119-t1x9gknd 9520 33 & & CC cord-010119-t1x9gknd 9520 34 p p NN cord-010119-t1x9gknd 9520 35 5 5 CD cord-010119-t1x9gknd 9520 36 0.3172 0.3172 CD cord-010119-t1x9gknd 9520 37 ; ; : cord-010119-t1x9gknd 9520 38 with with IN cord-010119-t1x9gknd 9520 39 95 95 CD cord-010119-t1x9gknd 9520 40 % % NN cord-010119-t1x9gknd 9520 41 CI CI NNP cord-010119-t1x9gknd 9520 42 5 5 CD cord-010119-t1x9gknd 9520 43 -0.0056 -0.0056 NN cord-010119-t1x9gknd 9520 44 to to IN cord-010119-t1x9gknd 9520 45 0.0077 0.0077 CD cord-010119-t1x9gknd 9520 46 between between IN cord-010119-t1x9gknd 9520 47 groups group NNS cord-010119-t1x9gknd 9520 48 B b NN cord-010119-t1x9gknd 9520 49 and and CC cord-010119-t1x9gknd 9520 50 C C NNP cord-010119-t1x9gknd 9520 51 ) ) -RRB- cord-010119-t1x9gknd 9520 52 . . . cord-010119-t1x9gknd 9521 1 In in IN cord-010119-t1x9gknd 9521 2 either either DT cord-010119-t1x9gknd 9521 3 group group NN cord-010119-t1x9gknd 9521 4 A a NN cord-010119-t1x9gknd 9521 5 and and CC cord-010119-t1x9gknd 9521 6 C C NNP cord-010119-t1x9gknd 9521 7 , , , cord-010119-t1x9gknd 9521 8 no no DT cord-010119-t1x9gknd 9521 9 NAT NAT NNP cord-010119-t1x9gknd 9521 10 - - HYPH cord-010119-t1x9gknd 9521 11 HIV HIV NNP cord-010119-t1x9gknd 9521 12 detected detect VBD cord-010119-t1x9gknd 9521 13 . . . cord-010119-t1x9gknd 9522 1 NAT NAT NNP cord-010119-t1x9gknd 9522 2 yield yield VBP cord-010119-t1x9gknd 9522 3 to to IN cord-010119-t1x9gknd 9522 4 the the DT cord-010119-t1x9gknd 9522 5 three three CD cord-010119-t1x9gknd 9522 6 viruses virus NNS cord-010119-t1x9gknd 9522 7 was be VBD cord-010119-t1x9gknd 9522 8 significantly significantly RB cord-010119-t1x9gknd 9522 9 higher high JJR cord-010119-t1x9gknd 9522 10 in in IN cord-010119-t1x9gknd 9522 11 males male NNS cord-010119-t1x9gknd 9522 12 than than IN cord-010119-t1x9gknd 9522 13 in in IN cord-010119-t1x9gknd 9522 14 females female NNS cord-010119-t1x9gknd 9522 15 ( ( -LRB- cord-010119-t1x9gknd 9522 16 p p NN cord-010119-t1x9gknd 9522 17 5 5 CD cord-010119-t1x9gknd 9522 18 0.0013 0.0013 CD cord-010119-t1x9gknd 9522 19 ; ; : cord-010119-t1x9gknd 9522 20 with with IN cord-010119-t1x9gknd 9522 21 95 95 CD cord-010119-t1x9gknd 9522 22 % % NN cord-010119-t1x9gknd 9522 23 CI CI NNP cord-010119-t1x9gknd 9522 24 5 5 CD cord-010119-t1x9gknd 9522 25 0.0136 0.0136 CD cord-010119-t1x9gknd 9522 26 to to IN cord-010119-t1x9gknd 9522 27 0.0507 0.0507 CD cord-010119-t1x9gknd 9522 28 ) ) -RRB- cord-010119-t1x9gknd 9522 29 . . . cord-010119-t1x9gknd 9523 1 NAT NAT NNP cord-010119-t1x9gknd 9523 2 HBV HBV NNP cord-010119-t1x9gknd 9523 3 was be VBD cord-010119-t1x9gknd 9523 4 significantly significantly RB cord-010119-t1x9gknd 9523 5 higher high JJR cord-010119-t1x9gknd 9523 6 in in IN cord-010119-t1x9gknd 9523 7 males male NNS cord-010119-t1x9gknd 9523 8 ( ( -LRB- cord-010119-t1x9gknd 9523 9 p p NN cord-010119-t1x9gknd 9523 10 5 5 CD cord-010119-t1x9gknd 9523 11 0.002 0.002 CD cord-010119-t1x9gknd 9523 12 ; ; : cord-010119-t1x9gknd 9523 13 with with IN cord-010119-t1x9gknd 9523 14 95 95 CD cord-010119-t1x9gknd 9523 15 % % NN cord-010119-t1x9gknd 9523 16 CI5 ci5 JJ cord-010119-t1x9gknd 9523 17 0.0103 0.0103 CD cord-010119-t1x9gknd 9523 18 -0.0413 -0.0413 VBD cord-010119-t1x9gknd 9523 19 ) ) -RRB- cord-010119-t1x9gknd 9523 20 , , , cord-010119-t1x9gknd 9523 21 but but CC cord-010119-t1x9gknd 9523 22 the the DT cord-010119-t1x9gknd 9523 23 prevalence prevalence NN cord-010119-t1x9gknd 9523 24 of of IN cord-010119-t1x9gknd 9523 25 either either CC cord-010119-t1x9gknd 9523 26 HCV HCV NNP cord-010119-t1x9gknd 9523 27 or or CC cord-010119-t1x9gknd 9523 28 HIV HIV NNP cord-010119-t1x9gknd 9523 29 did do VBD cord-010119-t1x9gknd 9523 30 not not RB cord-010119-t1x9gknd 9523 31 differ differ VB cord-010119-t1x9gknd 9523 32 significantly significantly RB cord-010119-t1x9gknd 9523 33 between between IN cord-010119-t1x9gknd 9523 34 males male NNS cord-010119-t1x9gknd 9523 35 and and CC cord-010119-t1x9gknd 9523 36 females female NNS cord-010119-t1x9gknd 9523 37 ( ( -LRB- cord-010119-t1x9gknd 9523 38 p p NN cord-010119-t1x9gknd 9523 39 5 5 CD cord-010119-t1x9gknd 9523 40 0.3835 0.3835 CD cord-010119-t1x9gknd 9523 41 ; ; : cord-010119-t1x9gknd 9523 42 with with IN cord-010119-t1x9gknd 9523 43 95 95 CD cord-010119-t1x9gknd 9523 44 % % NN cord-010119-t1x9gknd 9523 45 CI CI NNP cord-010119-t1x9gknd 9523 46 5 5 CD cord-010119-t1x9gknd 9524 1 -0.0077 -0.0077 UH cord-010119-t1x9gknd 9524 2 -0.0145 -0.0145 : cord-010119-t1x9gknd 9524 3 & & CC cord-010119-t1x9gknd 9524 4 p p NN cord-010119-t1x9gknd 9524 5 5 5 CD cord-010119-t1x9gknd 9524 6 0.2751 0.2751 CD cord-010119-t1x9gknd 9524 7 ; ; : cord-010119-t1x9gknd 9525 1 with with IN cord-010119-t1x9gknd 9525 2 95 95 CD cord-010119-t1x9gknd 9525 3 % % NN cord-010119-t1x9gknd 9525 4 CI CI NNP cord-010119-t1x9gknd 9525 5 5 5 CD cord-010119-t1x9gknd 9525 6 -0.0044 -0.0044 VBZ cord-010119-t1x9gknd 9525 7 -0.0066 -0.0066 : cord-010119-t1x9gknd 9525 8 ; ; : cord-010119-t1x9gknd 9525 9 respectively respectively RB cord-010119-t1x9gknd 9525 10 ) ) -RRB- cord-010119-t1x9gknd 9525 11 . . . cord-010119-t1x9gknd 9526 1 Conclusion conclusion NN cord-010119-t1x9gknd 9526 2 : : : cord-010119-t1x9gknd 9527 1 In in IN cord-010119-t1x9gknd 9527 2 this this DT cord-010119-t1x9gknd 9527 3 study study NN cord-010119-t1x9gknd 9527 4 The the DT cord-010119-t1x9gknd 9527 5 NAT NAT NNP cord-010119-t1x9gknd 9527 6 yield yield NN cord-010119-t1x9gknd 9527 7 of of IN cord-010119-t1x9gknd 9527 8 75 75 CD cord-010119-t1x9gknd 9527 9 in in IN cord-010119-t1x9gknd 9527 10 178685 178685 CD cord-010119-t1x9gknd 9527 11 assumes assume VBZ cord-010119-t1x9gknd 9527 12 more more JJR cord-010119-t1x9gknd 9527 13 significance significance NN cord-010119-t1x9gknd 9527 14 when when WRB cord-010119-t1x9gknd 9527 15 one one PRP cord-010119-t1x9gknd 9527 16 considers consider VBZ cord-010119-t1x9gknd 9527 17 the the DT cord-010119-t1x9gknd 9527 18 fact fact NN cord-010119-t1x9gknd 9527 19 that that IN cord-010119-t1x9gknd 9527 20 single single JJ cord-010119-t1x9gknd 9527 21 donation donation NN cord-010119-t1x9gknd 9527 22 is be VBZ cord-010119-t1x9gknd 9527 23 used use VBN cord-010119-t1x9gknd 9527 24 for for IN cord-010119-t1x9gknd 9527 25 generating generate VBG cord-010119-t1x9gknd 9527 26 3 3 CD cord-010119-t1x9gknd 9527 27 components component NNS cord-010119-t1x9gknd 9527 28 that that WDT cord-010119-t1x9gknd 9527 29 can can MD cord-010119-t1x9gknd 9527 30 be be VB cord-010119-t1x9gknd 9527 31 used use VBN cord-010119-t1x9gknd 9527 32 by by IN cord-010119-t1x9gknd 9527 33 3 3 CD cord-010119-t1x9gknd 9527 34 recipients recipient NNS cord-010119-t1x9gknd 9527 35 . . . cord-010119-t1x9gknd 9528 1 Hence hence RB cord-010119-t1x9gknd 9528 2 , , , cord-010119-t1x9gknd 9528 3 in in IN cord-010119-t1x9gknd 9528 4 effect effect NN cord-010119-t1x9gknd 9528 5 the the DT cord-010119-t1x9gknd 9528 6 NAT NAT NNP cord-010119-t1x9gknd 9528 7 yield yield NN cord-010119-t1x9gknd 9528 8 becomes become VBZ cord-010119-t1x9gknd 9528 9 3 3 CD cord-010119-t1x9gknd 9528 10 times time NNS cord-010119-t1x9gknd 9528 11 that that DT cord-010119-t1x9gknd 9528 12 is is RB cord-010119-t1x9gknd 9528 13 , , , cord-010119-t1x9gknd 9528 14 225 225 CD cord-010119-t1x9gknd 9528 15 in in IN cord-010119-t1x9gknd 9528 16 178685 178685 CD cord-010119-t1x9gknd 9528 17 . . . cord-010119-t1x9gknd 9529 1 Saving save VBG cord-010119-t1x9gknd 9529 2 225 225 CD cord-010119-t1x9gknd 9529 3 recipients recipient NNS cord-010119-t1x9gknd 9529 4 from from IN cord-010119-t1x9gknd 9529 5 TTI TTI NNP cord-010119-t1x9gknd 9529 6 out out IN cord-010119-t1x9gknd 9529 7 of of IN cord-010119-t1x9gknd 9529 8 178685 178685 CD cord-010119-t1x9gknd 9529 9 ( ( -LRB- cord-010119-t1x9gknd 9529 10 0.13 0.13 CD cord-010119-t1x9gknd 9529 11 % % NN cord-010119-t1x9gknd 9529 12 ) ) -RRB- cord-010119-t1x9gknd 9529 13 is be VBZ cord-010119-t1x9gknd 9529 14 indeed indeed RB cord-010119-t1x9gknd 9529 15 very very RB cord-010119-t1x9gknd 9529 16 significant significant JJ cord-010119-t1x9gknd 9529 17 . . . cord-010119-t1x9gknd 9530 1 Results result NNS cord-010119-t1x9gknd 9531 1 /Finding /finde VBG cord-010119-t1x9gknd 9531 2 : : : cord-010119-t1x9gknd 9531 3 Of of IN cord-010119-t1x9gknd 9531 4 the the DT cord-010119-t1x9gknd 9531 5 303,569 303,569 CD cord-010119-t1x9gknd 9531 6 donors donor NNS cord-010119-t1x9gknd 9531 7 who who WP cord-010119-t1x9gknd 9531 8 were be VBD cord-010119-t1x9gknd 9531 9 tested test VBN cord-010119-t1x9gknd 9531 10 by by IN cord-010119-t1x9gknd 9531 11 our -PRON- PRP$ cord-010119-t1x9gknd 9531 12 donor donor NN cord-010119-t1x9gknd 9531 13 center center NN cord-010119-t1x9gknd 9531 14 , , , cord-010119-t1x9gknd 9531 15 1,386 1,386 CD cord-010119-t1x9gknd 9531 16 ( ( -LRB- cord-010119-t1x9gknd 9531 17 0.460 0.460 CD cord-010119-t1x9gknd 9531 18 % % NN cord-010119-t1x9gknd 9531 19 ) ) -RRB- cord-010119-t1x9gknd 9531 20 were be VBD cord-010119-t1x9gknd 9531 21 repeat repeat NN cord-010119-t1x9gknd 9531 22 reactive reactive JJ cord-010119-t1x9gknd 9531 23 . . . cord-010119-t1x9gknd 9532 1 A a DT cord-010119-t1x9gknd 9532 2 seasonal seasonal JJ cord-010119-t1x9gknd 9532 3 pattern pattern NN cord-010119-t1x9gknd 9532 4 in in IN cord-010119-t1x9gknd 9532 5 the the DT cord-010119-t1x9gknd 9532 6 prevalence prevalence NN cord-010119-t1x9gknd 9532 7 was be VBD cord-010119-t1x9gknd 9532 8 observed observe VBN cord-010119-t1x9gknd 9532 9 with with IN cord-010119-t1x9gknd 9532 10 the the DT cord-010119-t1x9gknd 9532 11 highest high JJS cord-010119-t1x9gknd 9532 12 number number NN cord-010119-t1x9gknd 9532 13 of of IN cord-010119-t1x9gknd 9532 14 donors donor NNS cord-010119-t1x9gknd 9532 15 being be VBG cord-010119-t1x9gknd 9532 16 positive positive JJ cord-010119-t1x9gknd 9532 17 in in IN cord-010119-t1x9gknd 9532 18 summer summer NN cord-010119-t1x9gknd 9532 19 , , , cord-010119-t1x9gknd 9532 20 and and CC cord-010119-t1x9gknd 9532 21 then then RB cord-010119-t1x9gknd 9532 22 progressively progressively RB cord-010119-t1x9gknd 9532 23 declining decline VBG cord-010119-t1x9gknd 9532 24 during during IN cord-010119-t1x9gknd 9532 25 the the DT cord-010119-t1x9gknd 9532 26 fall fall NN cord-010119-t1x9gknd 9532 27 and and CC cord-010119-t1x9gknd 9532 28 winter winter NN cord-010119-t1x9gknd 9532 29 months month NNS cord-010119-t1x9gknd 9532 30 and and CC cord-010119-t1x9gknd 9532 31 increasing increase VBG cord-010119-t1x9gknd 9532 32 again again RB cord-010119-t1x9gknd 9532 33 in in IN cord-010119-t1x9gknd 9532 34 spring spring NN cord-010119-t1x9gknd 9532 35 . . . cord-010119-t1x9gknd 9533 1 There there EX cord-010119-t1x9gknd 9533 2 was be VBD cord-010119-t1x9gknd 9533 3 a a DT cord-010119-t1x9gknd 9533 4 single single JJ cord-010119-t1x9gknd 9533 5 case case NN cord-010119-t1x9gknd 9533 6 of of IN cord-010119-t1x9gknd 9533 7 transfusion transfusion NN cord-010119-t1x9gknd 9533 8 transmitted transmit VBN cord-010119-t1x9gknd 9533 9 babesiosis babesiosis NN cord-010119-t1x9gknd 9533 10 reported report VBN cord-010119-t1x9gknd 9533 11 from from IN cord-010119-t1x9gknd 9533 12 our -PRON- PRP$ cord-010119-t1x9gknd 9533 13 center center NN cord-010119-t1x9gknd 9533 14 during during IN cord-010119-t1x9gknd 9533 15 this this DT cord-010119-t1x9gknd 9533 16 period period NN cord-010119-t1x9gknd 9533 17 . . . cord-010119-t1x9gknd 9534 1 A a DT cord-010119-t1x9gknd 9534 2 patient patient NN cord-010119-t1x9gknd 9534 3 who who WP cord-010119-t1x9gknd 9534 4 was be VBD cord-010119-t1x9gknd 9534 5 transfused transfuse VBN cord-010119-t1x9gknd 9534 6 with with IN cord-010119-t1x9gknd 9534 7 two two CD cord-010119-t1x9gknd 9534 8 units unit NNS cord-010119-t1x9gknd 9534 9 of of IN cord-010119-t1x9gknd 9534 10 packed packed JJ cord-010119-t1x9gknd 9534 11 red red JJ cord-010119-t1x9gknd 9534 12 blood blood NN cord-010119-t1x9gknd 9534 13 cells cell NNS cord-010119-t1x9gknd 9534 14 ( ( -LRB- cord-010119-t1x9gknd 9534 15 RBCs rbc NNS cord-010119-t1x9gknd 9534 16 ) ) -RRB- cord-010119-t1x9gknd 9534 17 from from IN cord-010119-t1x9gknd 9534 18 two two CD cord-010119-t1x9gknd 9534 19 donors donor NNS cord-010119-t1x9gknd 9534 20 in in IN cord-010119-t1x9gknd 9534 21 the the DT cord-010119-t1x9gknd 9534 22 beginning beginning NN cord-010119-t1x9gknd 9534 23 of of IN cord-010119-t1x9gknd 9534 24 July July NNP cord-010119-t1x9gknd 9534 25 presented present VBN cord-010119-t1x9gknd 9534 26 in in IN cord-010119-t1x9gknd 9534 27 August August NNP cord-010119-t1x9gknd 9534 28 for for IN cord-010119-t1x9gknd 9534 29 further further JJ cord-010119-t1x9gknd 9534 30 transfusion transfusion NN cord-010119-t1x9gknd 9534 31 and and CC cord-010119-t1x9gknd 9534 32 was be VBD cord-010119-t1x9gknd 9534 33 found find VBN cord-010119-t1x9gknd 9534 34 to to TO cord-010119-t1x9gknd 9534 35 have have VB cord-010119-t1x9gknd 9534 36 parasitemia parasitemia NN cord-010119-t1x9gknd 9534 37 in in IN cord-010119-t1x9gknd 9534 38 the the DT cord-010119-t1x9gknd 9534 39 peripheral peripheral JJ cord-010119-t1x9gknd 9534 40 blood blood NN cord-010119-t1x9gknd 9534 41 smear smear NN cord-010119-t1x9gknd 9534 42 and and CC cord-010119-t1x9gknd 9534 43 was be VBD cord-010119-t1x9gknd 9534 44 subsequently subsequently RB cord-010119-t1x9gknd 9534 45 diagnosed diagnose VBN cord-010119-t1x9gknd 9534 46 with with IN cord-010119-t1x9gknd 9534 47 babesiosis babesiosi NNS cord-010119-t1x9gknd 9534 48 . . . cord-010119-t1x9gknd 9535 1 The the DT cord-010119-t1x9gknd 9535 2 donors donor NNS cord-010119-t1x9gknd 9535 3 were be VBD cord-010119-t1x9gknd 9535 4 called call VBN cord-010119-t1x9gknd 9535 5 back back RB cord-010119-t1x9gknd 9535 6 , , , cord-010119-t1x9gknd 9535 7 however however RB cord-010119-t1x9gknd 9535 8 one one CD cord-010119-t1x9gknd 9535 9 of of IN cord-010119-t1x9gknd 9535 10 them -PRON- PRP cord-010119-t1x9gknd 9535 11 could could MD cord-010119-t1x9gknd 9535 12 not not RB cord-010119-t1x9gknd 9535 13 be be VB cord-010119-t1x9gknd 9535 14 tracked track VBN cord-010119-t1x9gknd 9535 15 . . . cord-010119-t1x9gknd 9536 1 Samples sample NNS cord-010119-t1x9gknd 9536 2 were be VBD cord-010119-t1x9gknd 9536 3 sent send VBN cord-010119-t1x9gknd 9536 4 to to IN cord-010119-t1x9gknd 9536 5 the the DT cord-010119-t1x9gknd 9536 6 state state NN cord-010119-t1x9gknd 9536 7 for for IN cord-010119-t1x9gknd 9536 8 further further JJ cord-010119-t1x9gknd 9536 9 testing testing NN cord-010119-t1x9gknd 9536 10 : : : cord-010119-t1x9gknd 9536 11 An an DT cord-010119-t1x9gknd 9536 12 Immunofluoresence Immunofluoresence NNP cord-010119-t1x9gknd 9536 13 assay assay NN cord-010119-t1x9gknd 9536 14 was be VBD cord-010119-t1x9gknd 9536 15 performed perform VBN cord-010119-t1x9gknd 9536 16 ( ( -LRB- cord-010119-t1x9gknd 9536 17 combination combination NN cord-010119-t1x9gknd 9536 18 of of IN cord-010119-t1x9gknd 9536 19 IgG IgG NNP cord-010119-t1x9gknd 9536 20 , , , cord-010119-t1x9gknd 9536 21 IgM IgM NNP cord-010119-t1x9gknd 9536 22 and and CC cord-010119-t1x9gknd 9536 23 IgA IgA NNP cord-010119-t1x9gknd 9536 24 ) ) -RRB- cord-010119-t1x9gknd 9536 25 . . . cord-010119-t1x9gknd 9537 1 The the DT cord-010119-t1x9gknd 9537 2 test test NN cord-010119-t1x9gknd 9537 3 was be VBD cord-010119-t1x9gknd 9537 4 positive positive JJ cord-010119-t1x9gknd 9537 5 at at IN cord-010119-t1x9gknd 9537 6 1:128 1:128 CD cord-010119-t1x9gknd 9537 7 titer titer NN cord-010119-t1x9gknd 9537 8 . . . cord-010119-t1x9gknd 9538 1 The the DT cord-010119-t1x9gknd 9538 2 screening screening NN cord-010119-t1x9gknd 9538 3 ELIA ELIA NNP cord-010119-t1x9gknd 9538 4 S S NNP cord-010119-t1x9gknd 9538 5 / / SYM cord-010119-t1x9gknd 9538 6 CO CO NNP cord-010119-t1x9gknd 9538 7 of of IN cord-010119-t1x9gknd 9538 8 this this DT cord-010119-t1x9gknd 9538 9 donor donor NN cord-010119-t1x9gknd 9538 10 was be VBD cord-010119-t1x9gknd 9538 11 0.2782 0.2782 CD cord-010119-t1x9gknd 9538 12 . . . cord-010119-t1x9gknd 9539 1 Both both DT cord-010119-t1x9gknd 9539 2 donors donor NNS cord-010119-t1x9gknd 9539 3 were be VBD cord-010119-t1x9gknd 9539 4 indefinitely indefinitely RB cord-010119-t1x9gknd 9539 5 deferred defer VBN cord-010119-t1x9gknd 9539 6 as as IN cord-010119-t1x9gknd 9539 7 blood blood NN cord-010119-t1x9gknd 9539 8 donors donor NNS cord-010119-t1x9gknd 9539 9 . . . cord-010119-t1x9gknd 9540 1 Conclusion conclusion NN cord-010119-t1x9gknd 9540 2 : : : cord-010119-t1x9gknd 9541 1 Our -PRON- PRP$ cord-010119-t1x9gknd 9541 2 data datum NNS cord-010119-t1x9gknd 9541 3 confirm confirm VBP cord-010119-t1x9gknd 9541 4 a a DT cord-010119-t1x9gknd 9541 5 decreased decrease VBN cord-010119-t1x9gknd 9541 6 risk risk NN cord-010119-t1x9gknd 9541 7 in in IN cord-010119-t1x9gknd 9541 8 transfusion transfusion NN cord-010119-t1x9gknd 9541 9 transmission transmission NN cord-010119-t1x9gknd 9541 10 with with IN cord-010119-t1x9gknd 9541 11 the the DT cord-010119-t1x9gknd 9541 12 use use NN cord-010119-t1x9gknd 9541 13 of of IN cord-010119-t1x9gknd 9541 14 a a DT cord-010119-t1x9gknd 9541 15 screening screening NN cord-010119-t1x9gknd 9541 16 assay assay NN cord-010119-t1x9gknd 9541 17 . . . cord-010119-t1x9gknd 9542 1 Prior prior RB cord-010119-t1x9gknd 9542 2 to to IN cord-010119-t1x9gknd 9542 3 implementation implementation NN cord-010119-t1x9gknd 9542 4 of of IN cord-010119-t1x9gknd 9542 5 the the DT cord-010119-t1x9gknd 9542 6 screening screening NN cord-010119-t1x9gknd 9542 7 there there EX cord-010119-t1x9gknd 9542 8 were be VBD cord-010119-t1x9gknd 9543 1 6 6 LS cord-010119-t1x9gknd 9543 2 - - SYM cord-010119-t1x9gknd 9543 3 10 10 CD cord-010119-t1x9gknd 9543 4 transfusion transfusion NN cord-010119-t1x9gknd 9543 5 transmitted transmit VBN cord-010119-t1x9gknd 9543 6 babesia babesia JJ cord-010119-t1x9gknd 9543 7 cases case NNS cord-010119-t1x9gknd 9543 8 per per IN cord-010119-t1x9gknd 9543 9 year year NN cord-010119-t1x9gknd 9543 10 from from IN cord-010119-t1x9gknd 9543 11 2008 2008 CD cord-010119-t1x9gknd 9543 12 - - SYM cord-010119-t1x9gknd 9543 13 2015 2015 CD cord-010119-t1x9gknd 9544 1 ( ( -LRB- cord-010119-t1x9gknd 9544 2 Table table NN cord-010119-t1x9gknd 9544 3 2 2 CD cord-010119-t1x9gknd 9544 4 ) ) -RRB- cord-010119-t1x9gknd 9544 5 . . . cord-010119-t1x9gknd 9545 1 In in IN cord-010119-t1x9gknd 9545 2 the the DT cord-010119-t1x9gknd 9545 3 11 11 CD cord-010119-t1x9gknd 9545 4 months month NNS cord-010119-t1x9gknd 9545 5 after after IN cord-010119-t1x9gknd 9545 6 implementation implementation NN cord-010119-t1x9gknd 9545 7 of of IN cord-010119-t1x9gknd 9545 8 pre pre JJ cord-010119-t1x9gknd 9545 9 - - JJ cord-010119-t1x9gknd 9545 10 transfusion transfusion JJ cord-010119-t1x9gknd 9545 11 babesia babesia NN cord-010119-t1x9gknd 9545 12 screening screening NN cord-010119-t1x9gknd 9545 13 , , , cord-010119-t1x9gknd 9545 14 one one CD cord-010119-t1x9gknd 9545 15 break break NN cord-010119-t1x9gknd 9545 16 through through IN cord-010119-t1x9gknd 9545 17 case case NN cord-010119-t1x9gknd 9545 18 of of IN cord-010119-t1x9gknd 9545 19 transfusion transfusion NN cord-010119-t1x9gknd 9546 1 transmitted transmit VBN cord-010119-t1x9gknd 9546 2 babesia babesia NNP cord-010119-t1x9gknd 9546 3 was be VBD cord-010119-t1x9gknd 9546 4 observed observe VBN cord-010119-t1x9gknd 9546 5 ( ( -LRB- cord-010119-t1x9gknd 9546 6 1 1 CD cord-010119-t1x9gknd 9546 7 in in IN cord-010119-t1x9gknd 9546 8 303,569 303,569 CD cord-010119-t1x9gknd 9546 9 donors donor NNS cord-010119-t1x9gknd 9546 10 tested test VBN cord-010119-t1x9gknd 9546 11 ) ) -RRB- cord-010119-t1x9gknd 9546 12 . . . cord-010119-t1x9gknd 9547 1 Thus thus RB cord-010119-t1x9gknd 9547 2 the the DT cord-010119-t1x9gknd 9547 3 babesia babesia NNP cord-010119-t1x9gknd 9547 4 EIA EIA NNP cord-010119-t1x9gknd 9547 5 screening screening NN cord-010119-t1x9gknd 9547 6 test test NN cord-010119-t1x9gknd 9547 7 effectively effectively RB cord-010119-t1x9gknd 9547 8 prevents prevent VBZ cord-010119-t1x9gknd 9547 9 TTB TTB NNP cord-010119-t1x9gknd 9547 10 . . . cord-010119-t1x9gknd 9548 1 However however RB cord-010119-t1x9gknd 9548 2 , , , cord-010119-t1x9gknd 9548 3 there there EX cord-010119-t1x9gknd 9548 4 was be VBD cord-010119-t1x9gknd 9548 5 a a DT cord-010119-t1x9gknd 9548 6 substantial substantial JJ cord-010119-t1x9gknd 9548 7 loss loss NN cord-010119-t1x9gknd 9548 8 of of IN cord-010119-t1x9gknd 9548 9 donors donor NNS cord-010119-t1x9gknd 9548 10 due due JJ cord-010119-t1x9gknd 9548 11 to to IN cord-010119-t1x9gknd 9548 12 being be VBG cord-010119-t1x9gknd 9548 13 screen screen NN cord-010119-t1x9gknd 9548 14 positive positive JJ cord-010119-t1x9gknd 9548 15 . . . cord-010119-t1x9gknd 9549 1 Four four CD cord-010119-t1x9gknd 9549 2 Years year NNS cord-010119-t1x9gknd 9549 3 of of IN cord-010119-t1x9gknd 9549 4 Experience experience NN cord-010119-t1x9gknd 9549 5 with with IN cord-010119-t1x9gknd 9549 6 ID ID NNP cord-010119-t1x9gknd 9549 7 - - HYPH cord-010119-t1x9gknd 9549 8 NAT NAT NNP cord-010119-t1x9gknd 9549 9 at at IN cord-010119-t1x9gknd 9549 10 a a DT cord-010119-t1x9gknd 9549 11 Tertiary Tertiary NNP cord-010119-t1x9gknd 9549 12 Care Care NNP cord-010119-t1x9gknd 9549 13 Centre Centre NNP cord-010119-t1x9gknd 9549 14 in in IN cord-010119-t1x9gknd 9549 15 North North NNP cord-010119-t1x9gknd 9549 16 India India NNP cord-010119-t1x9gknd 9549 17 : : : cord-010119-t1x9gknd 9549 18 Implications implication NNS cord-010119-t1x9gknd 9549 19 for for IN cord-010119-t1x9gknd 9549 20 Transfusion Transfusion NNP cord-010119-t1x9gknd 9549 21 Transmission Transmission NNP cord-010119-t1x9gknd 9549 22 and and CC cord-010119-t1x9gknd 9549 23 Donor Donor NNP cord-010119-t1x9gknd 9549 24 Screening Screening NNP cord-010119-t1x9gknd 9549 25 . . . cord-010119-t1x9gknd 9550 1 Jasmeet Jasmeet NNP cord-010119-t1x9gknd 9550 2 Singh Singh NNP cord-010119-t1x9gknd 9550 3 * * NFP cord-010119-t1x9gknd 9550 4 , , , cord-010119-t1x9gknd 9550 5 Amarjit Amarjit NNP cord-010119-t1x9gknd 9550 6 Kaur Kaur NNP cord-010119-t1x9gknd 9550 7 , , , cord-010119-t1x9gknd 9550 8 Gurpreet Gurpreet NNP cord-010119-t1x9gknd 9550 9 Kaur Kaur NNP cord-010119-t1x9gknd 9550 10 , , , cord-010119-t1x9gknd 9550 11 Rajesh Rajesh NNP cord-010119-t1x9gknd 9550 12 Kumar Kumar NNP cord-010119-t1x9gknd 9550 13 and and CC cord-010119-t1x9gknd 9550 14 Sonia Sonia NNP cord-010119-t1x9gknd 9550 15 Gupta Gupta NNP cord-010119-t1x9gknd 9550 16 . . . cord-010119-t1x9gknd 9551 1 Dayanand Dayanand NNP cord-010119-t1x9gknd 9551 2 Medical Medical NNP cord-010119-t1x9gknd 9551 3 College College NNP cord-010119-t1x9gknd 9551 4 and and CC cord-010119-t1x9gknd 9551 5 Hospital Hospital NNP cord-010119-t1x9gknd 9551 6 Background Background NNP cord-010119-t1x9gknd 9551 7 / / SYM cord-010119-t1x9gknd 9551 8 Case Case NNP cord-010119-t1x9gknd 9551 9 Studies Studies NNPS cord-010119-t1x9gknd 9551 10 : : : cord-010119-t1x9gknd 9552 1 Transfusion transfusion NN cord-010119-t1x9gknd 9552 2 transmitted transmit VBD cord-010119-t1x9gknd 9552 3 diseases disease NNS cord-010119-t1x9gknd 9552 4 are be VBP cord-010119-t1x9gknd 9552 5 a a DT cord-010119-t1x9gknd 9552 6 challenge challenge NN cord-010119-t1x9gknd 9552 7 for for IN cord-010119-t1x9gknd 9552 8 transfusion transfusion NN cord-010119-t1x9gknd 9552 9 medicine medicine NN cord-010119-t1x9gknd 9552 10 specialists specialist NNS cord-010119-t1x9gknd 9552 11 and and CC cord-010119-t1x9gknd 9552 12 patient patient JJ cord-010119-t1x9gknd 9552 13 care care NN cord-010119-t1x9gknd 9552 14 providers provider NNS cord-010119-t1x9gknd 9552 15 around around IN cord-010119-t1x9gknd 9552 16 the the DT cord-010119-t1x9gknd 9552 17 globe globe NN cord-010119-t1x9gknd 9552 18 . . . cord-010119-t1x9gknd 9553 1 Blood blood NN cord-010119-t1x9gknd 9553 2 safety safety NN cord-010119-t1x9gknd 9553 3 is be VBZ cord-010119-t1x9gknd 9553 4 a a DT cord-010119-t1x9gknd 9553 5 formidable formidable JJ cord-010119-t1x9gknd 9553 6 task task NN cord-010119-t1x9gknd 9553 7 especially especially RB cord-010119-t1x9gknd 9553 8 in in IN cord-010119-t1x9gknd 9553 9 a a DT cord-010119-t1x9gknd 9553 10 high high JJ cord-010119-t1x9gknd 9553 11 population population NN cord-010119-t1x9gknd 9553 12 country country NN cord-010119-t1x9gknd 9553 13 like like IN cord-010119-t1x9gknd 9553 14 India India NNP cord-010119-t1x9gknd 9553 15 . . . cord-010119-t1x9gknd 9554 1 Newer new JJR cord-010119-t1x9gknd 9554 2 technologies technology NNS cord-010119-t1x9gknd 9554 3 like like IN cord-010119-t1x9gknd 9554 4 ID ID NNP cord-010119-t1x9gknd 9554 5 - - HYPH cord-010119-t1x9gknd 9554 6 NAT NAT NNP cord-010119-t1x9gknd 9554 7 equip equip VB cord-010119-t1x9gknd 9554 8 us -PRON- PRP cord-010119-t1x9gknd 9554 9 to to TO cord-010119-t1x9gknd 9554 10 screen screen VB cord-010119-t1x9gknd 9554 11 and and CC cord-010119-t1x9gknd 9554 12 prevent prevent VB cord-010119-t1x9gknd 9554 13 transfusion transfusion NN cord-010119-t1x9gknd 9554 14 transmitted transmit VBN cord-010119-t1x9gknd 9554 15 viral viral JJ cord-010119-t1x9gknd 9554 16 infections infection NNS cord-010119-t1x9gknd 9554 17 and and CC cord-010119-t1x9gknd 9554 18 prevent prevent VB cord-010119-t1x9gknd 9554 19 their -PRON- PRP$ cord-010119-t1x9gknd 9554 20 transmission transmission NN cord-010119-t1x9gknd 9554 21 by by IN cord-010119-t1x9gknd 9554 22 improving improve VBG cord-010119-t1x9gknd 9554 23 over over IN cord-010119-t1x9gknd 9554 24 the the DT cord-010119-t1x9gknd 9554 25 sensitivity sensitivity NN cord-010119-t1x9gknd 9554 26 and and CC cord-010119-t1x9gknd 9554 27 specificity specificity NN cord-010119-t1x9gknd 9554 28 of of IN cord-010119-t1x9gknd 9554 29 conventional conventional JJ cord-010119-t1x9gknd 9554 30 methods method NNS cord-010119-t1x9gknd 9554 31 . . . cord-010119-t1x9gknd 9555 1 This this DT cord-010119-t1x9gknd 9555 2 study study NN cord-010119-t1x9gknd 9555 3 aims aim VBZ cord-010119-t1x9gknd 9555 4 at at IN cord-010119-t1x9gknd 9555 5 examining examine VBG cord-010119-t1x9gknd 9555 6 the the DT cord-010119-t1x9gknd 9555 7 effect effect NN cord-010119-t1x9gknd 9555 8 of of IN cord-010119-t1x9gknd 9555 9 ID ID NNP cord-010119-t1x9gknd 9555 10 - - HYPH cord-010119-t1x9gknd 9555 11 NAT NAT NNP cord-010119-t1x9gknd 9555 12 as as IN cord-010119-t1x9gknd 9555 13 an an DT cord-010119-t1x9gknd 9555 14 additional additional JJ cord-010119-t1x9gknd 9555 15 test test NN cord-010119-t1x9gknd 9555 16 on on IN cord-010119-t1x9gknd 9555 17 the the DT cord-010119-t1x9gknd 9555 18 safety safety NN cord-010119-t1x9gknd 9555 19 of of IN cord-010119-t1x9gknd 9555 20 blood blood NN cord-010119-t1x9gknd 9555 21 supply supply NN cord-010119-t1x9gknd 9555 22 . . . cord-010119-t1x9gknd 9556 1 Study Study NNP cord-010119-t1x9gknd 9556 2 Design Design NNP cord-010119-t1x9gknd 9556 3 / / SYM cord-010119-t1x9gknd 9556 4 Method method NN cord-010119-t1x9gknd 9556 5 : : : cord-010119-t1x9gknd 9557 1 A a DT cord-010119-t1x9gknd 9557 2 retrospective retrospective JJ cord-010119-t1x9gknd 9557 3 observational observational JJ cord-010119-t1x9gknd 9557 4 study study NN cord-010119-t1x9gknd 9557 5 was be VBD cord-010119-t1x9gknd 9557 6 conducted conduct VBN cord-010119-t1x9gknd 9557 7 to to TO cord-010119-t1x9gknd 9557 8 analyze analyze VB cord-010119-t1x9gknd 9557 9 the the DT cord-010119-t1x9gknd 9557 10 data datum NNS cord-010119-t1x9gknd 9557 11 of of IN cord-010119-t1x9gknd 9557 12 4 4 CD cord-010119-t1x9gknd 9557 13 years year NNS cord-010119-t1x9gknd 9557 14 of of IN cord-010119-t1x9gknd 9557 15 additional additional JJ cord-010119-t1x9gknd 9557 16 NAT NAT NNP cord-010119-t1x9gknd 9557 17 testing testing NN cord-010119-t1x9gknd 9557 18 at at IN cord-010119-t1x9gknd 9557 19 Blood Blood NNP cord-010119-t1x9gknd 9557 20 Bank Bank NNP cord-010119-t1x9gknd 9557 21 , , , cord-010119-t1x9gknd 9557 22 DMCH DMCH NNP cord-010119-t1x9gknd 9557 23 , , , cord-010119-t1x9gknd 9557 24 Ludhiana Ludhiana NNP cord-010119-t1x9gknd 9557 25 from from IN cord-010119-t1x9gknd 9557 26 September September NNP cord-010119-t1x9gknd 9557 27 2012 2012 CD cord-010119-t1x9gknd 9557 28 to to IN cord-010119-t1x9gknd 9557 29 December December NNP cord-010119-t1x9gknd 9557 30 2016 2016 CD cord-010119-t1x9gknd 9557 31 . . . cord-010119-t1x9gknd 9558 1 Results result NNS cord-010119-t1x9gknd 9558 2 / / SYM cord-010119-t1x9gknd 9558 3 Finding finding NN cord-010119-t1x9gknd 9558 4 : : : cord-010119-t1x9gknd 9559 1 Results result NNS cord-010119-t1x9gknd 9559 2 1.73 1.73 CD cord-010119-t1x9gknd 9559 3 % % NN cord-010119-t1x9gknd 9559 4 ( ( -LRB- cord-010119-t1x9gknd 9559 5 2041 2041 CD cord-010119-t1x9gknd 9559 6 of of IN cord-010119-t1x9gknd 9559 7 118021 118021 CD cord-010119-t1x9gknd 9559 8 ) ) -RRB- cord-010119-t1x9gknd 9559 9 units unit NNS cord-010119-t1x9gknd 9559 10 were be VBD cord-010119-t1x9gknd 9559 11 initially initially RB cord-010119-t1x9gknd 9559 12 NAT NAT NNP cord-010119-t1x9gknd 9559 13 reactive reactive JJ cord-010119-t1x9gknd 9559 14 . . . cord-010119-t1x9gknd 9560 1 These these DT cord-010119-t1x9gknd 9560 2 units unit NNS cord-010119-t1x9gknd 9560 3 were be VBD cord-010119-t1x9gknd 9560 4 further further RB cord-010119-t1x9gknd 9560 5 tested test VBN cord-010119-t1x9gknd 9560 6 , , , cord-010119-t1x9gknd 9560 7 of of IN cord-010119-t1x9gknd 9560 8 which which WDT cord-010119-t1x9gknd 9560 9 90.98 90.98 CD cord-010119-t1x9gknd 9560 10 % % NN cord-010119-t1x9gknd 9560 11 were be VBD cord-010119-t1x9gknd 9560 12 discriminated discriminate VBN cord-010119-t1x9gknd 9560 13 ( ( -LRB- cord-010119-t1x9gknd 9560 14 70 70 CD cord-010119-t1x9gknd 9560 15 HIV HIV NNP cord-010119-t1x9gknd 9560 16 , , , cord-010119-t1x9gknd 9560 17 1051 1051 CD cord-010119-t1x9gknd 9560 18 HCV HCV NNP cord-010119-t1x9gknd 9560 19 , , , cord-010119-t1x9gknd 9560 20 726 726 CD cord-010119-t1x9gknd 9560 21 HBV HBV NNP cord-010119-t1x9gknd 9560 22 and and CC cord-010119-t1x9gknd 9560 23 10 10 CD cord-010119-t1x9gknd 9560 24 co co NNS cord-010119-t1x9gknd 9560 25 - - NNS cord-010119-t1x9gknd 9560 26 infections infection NNS cord-010119-t1x9gknd 9560 27 ) ) -RRB- cord-010119-t1x9gknd 9560 28 . . . cord-010119-t1x9gknd 9561 1 The the DT cord-010119-t1x9gknd 9561 2 remaining remain VBG cord-010119-t1x9gknd 9561 3 6.71 6.71 CD cord-010119-t1x9gknd 9561 4 % % NN cord-010119-t1x9gknd 9561 5 ( ( -LRB- cord-010119-t1x9gknd 9561 6 137 137 CD cord-010119-t1x9gknd 9561 7 ) ) -RRB- cord-010119-t1x9gknd 9561 8 were be VBD cord-010119-t1x9gknd 9561 9 repeat repeat VB cord-010119-t1x9gknd 9561 10 non non JJ cord-010119-t1x9gknd 9561 11 - - JJ cord-010119-t1x9gknd 9561 12 reactive reactive JJ cord-010119-t1x9gknd 9561 13 and and CC cord-010119-t1x9gknd 9561 14 1.91 1.91 CD cord-010119-t1x9gknd 9561 15 % % NN cord-010119-t1x9gknd 9561 16 ( ( -LRB- cord-010119-t1x9gknd 9561 17 39 39 CD cord-010119-t1x9gknd 9561 18 ) ) -RRB- cord-010119-t1x9gknd 9561 19 could could MD cord-010119-t1x9gknd 9561 20 not not RB cord-010119-t1x9gknd 9561 21 be be VB cord-010119-t1x9gknd 9561 22 discriminated discriminate VBN cord-010119-t1x9gknd 9561 23 . . . cord-010119-t1x9gknd 9562 1 Overall overall RB cord-010119-t1x9gknd 9562 2 , , , cord-010119-t1x9gknd 9562 3 NAT NAT NNP cord-010119-t1x9gknd 9562 4 yield yield NN cord-010119-t1x9gknd 9562 5 rate rate NN cord-010119-t1x9gknd 9562 6 was be VBD cord-010119-t1x9gknd 9562 7 one one CD cord-010119-t1x9gknd 9562 8 in in IN cord-010119-t1x9gknd 9562 9 837 837 CD cord-010119-t1x9gknd 9562 10 , , , cord-010119-t1x9gknd 9562 11 whereas whereas IN cord-010119-t1x9gknd 9562 12 virus virus NN cord-010119-t1x9gknd 9562 13 - - HYPH cord-010119-t1x9gknd 9562 14 specific specific JJ cord-010119-t1x9gknd 9562 15 NAT NAT NNP cord-010119-t1x9gknd 9562 16 yield yield NN cord-010119-t1x9gknd 9562 17 rates rate NNS cord-010119-t1x9gknd 9562 18 were be VBD cord-010119-t1x9gknd 9562 19 one one CD cord-010119-t1x9gknd 9562 20 in in IN cord-010119-t1x9gknd 9562 21 59,010 59,010 CD cord-010119-t1x9gknd 9562 22 for for IN cord-010119-t1x9gknd 9562 23 HIV HIV NNP cord-010119-t1x9gknd 9562 24 , , , cord-010119-t1x9gknd 9562 25 one one CD cord-010119-t1x9gknd 9562 26 in in IN cord-010119-t1x9gknd 9562 27 1873 1873 CD cord-010119-t1x9gknd 9562 28 for for IN cord-010119-t1x9gknd 9562 29 HCV HCV NNP cord-010119-t1x9gknd 9562 30 , , , cord-010119-t1x9gknd 9562 31 one one CD cord-010119-t1x9gknd 9562 32 in in IN cord-010119-t1x9gknd 9562 33 1639 1639 CD cord-010119-t1x9gknd 9562 34 for for IN cord-010119-t1x9gknd 9562 35 HBV HBV NNP cord-010119-t1x9gknd 9562 36 and and CC cord-010119-t1x9gknd 9562 37 one one CD cord-010119-t1x9gknd 9562 38 in in IN cord-010119-t1x9gknd 9562 39 29,505 29,505 CD cord-010119-t1x9gknd 9562 40 for for IN cord-010119-t1x9gknd 9562 41 HBV HBV NNP cord-010119-t1x9gknd 9562 42 / / SYM cord-010119-t1x9gknd 9562 43 HCV HCV NNP cord-010119-t1x9gknd 9562 44 Coinfections Coinfections NNP cord-010119-t1x9gknd 9562 45 , , , cord-010119-t1x9gknd 9562 46 respectively respectively RB cord-010119-t1x9gknd 9562 47 . . . cord-010119-t1x9gknd 9563 1 Conclusion conclusion NN cord-010119-t1x9gknd 9563 2 : : : cord-010119-t1x9gknd 9563 3 ID ID NNP cord-010119-t1x9gknd 9563 4 - - HYPH cord-010119-t1x9gknd 9563 5 NAT NAT NNP cord-010119-t1x9gknd 9563 6 screening screening NN cord-010119-t1x9gknd 9563 7 of of IN cord-010119-t1x9gknd 9563 8 all all DT cord-010119-t1x9gknd 9563 9 blood blood NN cord-010119-t1x9gknd 9563 10 donations donation NNS cord-010119-t1x9gknd 9563 11 at at IN cord-010119-t1x9gknd 9563 12 our -PRON- PRP$ cord-010119-t1x9gknd 9563 13 institution institution NN cord-010119-t1x9gknd 9563 14 over over IN cord-010119-t1x9gknd 9563 15 past past JJ cord-010119-t1x9gknd 9563 16 4 4 CD cord-010119-t1x9gknd 9563 17 years year NNS cord-010119-t1x9gknd 9563 18 has have VBZ cord-010119-t1x9gknd 9563 19 increased increase VBN cord-010119-t1x9gknd 9563 20 the the DT cord-010119-t1x9gknd 9563 21 screening screening NN cord-010119-t1x9gknd 9563 22 sensitivities sensitivity NNS cord-010119-t1x9gknd 9563 23 to to TO cord-010119-t1x9gknd 9563 24 check check VB cord-010119-t1x9gknd 9563 25 viral viral JJ cord-010119-t1x9gknd 9563 26 load load NN cord-010119-t1x9gknd 9563 27 and and CC cord-010119-t1x9gknd 9563 28 prevented prevent VBD cord-010119-t1x9gknd 9563 29 transmission transmission NN cord-010119-t1x9gknd 9563 30 of of IN cord-010119-t1x9gknd 9563 31 141 141 CD cord-010119-t1x9gknd 9563 32 probable probable JJ cord-010119-t1x9gknd 9563 33 transfusion transfusion NN cord-010119-t1x9gknd 9563 34 transmitted transmit VBN cord-010119-t1x9gknd 9563 35 viral viral JJ cord-010119-t1x9gknd 9563 36 infections infection NNS cord-010119-t1x9gknd 9563 37 . . . cord-010119-t1x9gknd 9564 1 Assuming assume VBG cord-010119-t1x9gknd 9564 2 100 100 CD cord-010119-t1x9gknd 9564 3 % % NN cord-010119-t1x9gknd 9564 4 component component NN cord-010119-t1x9gknd 9564 5 preparation preparation NN cord-010119-t1x9gknd 9564 6 it -PRON- PRP cord-010119-t1x9gknd 9564 7 saved save VBD cord-010119-t1x9gknd 9564 8 423 423 CD cord-010119-t1x9gknd 9564 9 transfusion transfusion NN cord-010119-t1x9gknd 9564 10 recipients recipient NNS cord-010119-t1x9gknd 9564 11 from from IN cord-010119-t1x9gknd 9564 12 harm harm NN cord-010119-t1x9gknd 9564 13 . . . cord-010119-t1x9gknd 9565 1 Implementation implementation NN cord-010119-t1x9gknd 9565 2 of of IN cord-010119-t1x9gknd 9565 3 NAT NAT NNP cord-010119-t1x9gknd 9565 4 along along IN cord-010119-t1x9gknd 9565 5 with with IN cord-010119-t1x9gknd 9565 6 routine routine JJ cord-010119-t1x9gknd 9565 7 serological serological JJ cord-010119-t1x9gknd 9565 8 tests test NNS cord-010119-t1x9gknd 9565 9 for for IN cord-010119-t1x9gknd 9565 10 screening screening NN cord-010119-t1x9gknd 9565 11 of of IN cord-010119-t1x9gknd 9565 12 the the DT cord-010119-t1x9gknd 9565 13 blood blood NN cord-010119-t1x9gknd 9565 14 donations donation NNS cord-010119-t1x9gknd 9565 15 definitely definitely RB cord-010119-t1x9gknd 9565 16 improves improve VBZ cord-010119-t1x9gknd 9565 17 the the DT cord-010119-t1x9gknd 9565 18 transfusion transfusion NN cord-010119-t1x9gknd 9565 19 safety safety NN cord-010119-t1x9gknd 9565 20 and and CC cord-010119-t1x9gknd 9565 21 should should MD cord-010119-t1x9gknd 9565 22 be be VB cord-010119-t1x9gknd 9565 23 mandated mandate VBN cord-010119-t1x9gknd 9565 24 across across IN cord-010119-t1x9gknd 9565 25 all all DT cord-010119-t1x9gknd 9565 26 transfusion transfusion NN cord-010119-t1x9gknd 9565 27 centers center NNS cord-010119-t1x9gknd 9565 28 . . . cord-010119-t1x9gknd 9566 1 Min Min NNP cord-010119-t1x9gknd 9566 2 Xu Xu NNP cord-010119-t1x9gknd 9566 3 1,2 1,2 CD cord-010119-t1x9gknd 9567 1 , , , cord-010119-t1x9gknd 9567 2 Wei Wei NNP cord-010119-t1x9gknd 9567 3 Mao Mao NNP cord-010119-t1x9gknd 9567 4 3 3 CD cord-010119-t1x9gknd 9567 5 , , , cord-010119-t1x9gknd 9567 6 Tao Tao NNP cord-010119-t1x9gknd 9567 7 He He NNP cord-010119-t1x9gknd 9567 8 3 3 CD cord-010119-t1x9gknd 9567 9 , , , cord-010119-t1x9gknd 9567 10 Yashan Yashan NNP cord-010119-t1x9gknd 9567 11 Yang Yang NNP cord-010119-t1x9gknd 9567 12 1,2 1,2 CD cord-010119-t1x9gknd 9567 13 , , , cord-010119-t1x9gknd 9567 14 Zhan Zhan NNP cord-010119-t1x9gknd 9567 15 Gao Gao NNP cord-010119-t1x9gknd 9567 16 1,2 1,2 CD cord-010119-t1x9gknd 9567 17 , , , cord-010119-t1x9gknd 9567 18 Chunhong Chunhong NNP cord-010119-t1x9gknd 9567 19 Zhang Zhang NNP cord-010119-t1x9gknd 9567 20 3 3 CD cord-010119-t1x9gknd 9567 21 , , , cord-010119-t1x9gknd 9567 22 Hongmei Hongmei NNP cord-010119-t1x9gknd 9567 23 Liao Liao NNP cord-010119-t1x9gknd 9567 24 3 3 CD cord-010119-t1x9gknd 9567 25 , , , cord-010119-t1x9gknd 9567 26 Jingxing Jingxing NNP cord-010119-t1x9gknd 9567 27 Wang Wang NNP cord-010119-t1x9gknd 9567 28 1,2 1,2 CD cord-010119-t1x9gknd 9567 29 and and CC cord-010119-t1x9gknd 9568 1 Miao Miao NNP cord-010119-t1x9gknd 9568 2 He -PRON- PRP cord-010119-t1x9gknd 9568 3 * * NFP cord-010119-t1x9gknd 9568 4 1,2 1,2 CD cord-010119-t1x9gknd 9568 5 . . . cord-010119-t1x9gknd 9568 6 1 1 CD cord-010119-t1x9gknd 9568 7 Institute Institute NNP cord-010119-t1x9gknd 9568 8 of of IN cord-010119-t1x9gknd 9568 9 Blood Blood NNP cord-010119-t1x9gknd 9568 10 Transfusion Transfusion NNP cord-010119-t1x9gknd 9568 11 , , , cord-010119-t1x9gknd 9568 12 Chinese Chinese NNP cord-010119-t1x9gknd 9568 13 Academy Academy NNP cord-010119-t1x9gknd 9568 14 of of IN cord-010119-t1x9gknd 9568 15 Medical Medical NNP cord-010119-t1x9gknd 9568 16 Sciences Sciences NNPS cord-010119-t1x9gknd 9568 17 & & CC cord-010119-t1x9gknd 9568 18 Peking Peking NNP cord-010119-t1x9gknd 9568 19 Union Union NNP cord-010119-t1x9gknd 9568 20 Medical Medical NNP cord-010119-t1x9gknd 9568 21 College College NNP cord-010119-t1x9gknd 9568 22 , , , cord-010119-t1x9gknd 9568 23 2 2 CD cord-010119-t1x9gknd 9568 24 Sichuan Sichuan NNP cord-010119-t1x9gknd 9568 25 Blood Blood NNP cord-010119-t1x9gknd 9568 26 Safety Safety NNP cord-010119-t1x9gknd 9568 27 and and CC cord-010119-t1x9gknd 9568 28 Blood Blood NNP cord-010119-t1x9gknd 9568 29 Substitute Substitute NNP cord-010119-t1x9gknd 9568 30 International International NNP cord-010119-t1x9gknd 9568 31 Science Science NNP cord-010119-t1x9gknd 9568 32 and and CC cord-010119-t1x9gknd 9568 33 Technology Technology NNP cord-010119-t1x9gknd 9568 34 Cooperation Cooperation NNP cord-010119-t1x9gknd 9568 35 Base Base NNP cord-010119-t1x9gknd 9568 36 , , , cord-010119-t1x9gknd 9568 37 3 3 CD cord-010119-t1x9gknd 9568 38 Chongqing Chongqing NNP cord-010119-t1x9gknd 9568 39 Blood Blood NNP cord-010119-t1x9gknd 9568 40 Center Center NNP cord-010119-t1x9gknd 9568 41 Background Background NNP cord-010119-t1x9gknd 9568 42 / / SYM cord-010119-t1x9gknd 9568 43 Case Case NNP cord-010119-t1x9gknd 9568 44 Studies Studies NNPS cord-010119-t1x9gknd 9569 1 : : : cord-010119-t1x9gknd 9569 2 Many many JJ cord-010119-t1x9gknd 9569 3 emerging emerge VBG cord-010119-t1x9gknd 9569 4 infectious infectious JJ cord-010119-t1x9gknd 9569 5 pathogens pathogen NNS cord-010119-t1x9gknd 9569 6 are be VBP cord-010119-t1x9gknd 9569 7 known know VBN cord-010119-t1x9gknd 9569 8 to to TO cord-010119-t1x9gknd 9569 9 be be VB cord-010119-t1x9gknd 9569 10 existed exist VBN cord-010119-t1x9gknd 9569 11 in in IN cord-010119-t1x9gknd 9569 12 heathy heathy JJ cord-010119-t1x9gknd 9569 13 blood blood NN cord-010119-t1x9gknd 9569 14 donations donation NNS cord-010119-t1x9gknd 9569 15 , , , cord-010119-t1x9gknd 9569 16 and and CC cord-010119-t1x9gknd 9569 17 could could MD cord-010119-t1x9gknd 9569 18 be be VB cord-010119-t1x9gknd 9569 19 transmitted transmit VBN cord-010119-t1x9gknd 9569 20 via via IN cord-010119-t1x9gknd 9569 21 transfusion transfusion NN cord-010119-t1x9gknd 9569 22 with with IN cord-010119-t1x9gknd 9569 23 potential potential JJ cord-010119-t1x9gknd 9569 24 hazardous hazardous JJ cord-010119-t1x9gknd 9569 25 consequences consequence NNS cord-010119-t1x9gknd 9569 26 against against IN cord-010119-t1x9gknd 9569 27 recipients recipient NNS cord-010119-t1x9gknd 9569 28 . . . cord-010119-t1x9gknd 9570 1 With with IN cord-010119-t1x9gknd 9570 2 more more RBR cord-010119-t1x9gknd 9570 3 convenient convenient JJ cord-010119-t1x9gknd 9570 4 application application NN cord-010119-t1x9gknd 9570 5 of of IN cord-010119-t1x9gknd 9570 6 high high JJ cord-010119-t1x9gknd 9570 7 through through IN cord-010119-t1x9gknd 9570 8 put put VBN cord-010119-t1x9gknd 9570 9 sequencing sequencing NN cord-010119-t1x9gknd 9570 10 , , , cord-010119-t1x9gknd 9570 11 it -PRON- PRP cord-010119-t1x9gknd 9570 12 becomes become VBZ cord-010119-t1x9gknd 9570 13 much much RB cord-010119-t1x9gknd 9570 14 easier easy JJR cord-010119-t1x9gknd 9570 15 to to TO cord-010119-t1x9gknd 9570 16 investigate investigate VB cord-010119-t1x9gknd 9570 17 uncultured uncultured JJ cord-010119-t1x9gknd 9570 18 microbiome microbiome NN cord-010119-t1x9gknd 9570 19 in in IN cord-010119-t1x9gknd 9570 20 qualified qualified JJ cord-010119-t1x9gknd 9570 21 blood blood NN cord-010119-t1x9gknd 9570 22 donations donation NNS cord-010119-t1x9gknd 9570 23 . . . cord-010119-t1x9gknd 9571 1 Therefore therefore RB cord-010119-t1x9gknd 9571 2 , , , cord-010119-t1x9gknd 9571 3 metagenomics metagenomics NN cord-010119-t1x9gknd 9571 4 analyses analysis NNS cord-010119-t1x9gknd 9571 5 were be VBD cord-010119-t1x9gknd 9571 6 used use VBN cord-010119-t1x9gknd 9571 7 to to TO cord-010119-t1x9gknd 9571 8 reveal reveal VB cord-010119-t1x9gknd 9571 9 emerging emerge VBG cord-010119-t1x9gknd 9571 10 and and CC cord-010119-t1x9gknd 9571 11 re re VB cord-010119-t1x9gknd 9571 12 - - JJ cord-010119-t1x9gknd 9571 13 emerging emerge VBG cord-010119-t1x9gknd 9571 14 infectious infectious JJ cord-010119-t1x9gknd 9571 15 diseases disease NNS cord-010119-t1x9gknd 9571 16 in in IN cord-010119-t1x9gknd 9571 17 healthy healthy JJ cord-010119-t1x9gknd 9571 18 donations donation NNS cord-010119-t1x9gknd 9571 19 which which WDT cord-010119-t1x9gknd 9571 20 might may MD cord-010119-t1x9gknd 9571 21 potentially potentially RB cord-010119-t1x9gknd 9571 22 threat threat VB cord-010119-t1x9gknd 9571 23 the the DT cord-010119-t1x9gknd 9571 24 blood blood NN cord-010119-t1x9gknd 9571 25 safety safety NN cord-010119-t1x9gknd 9571 26 . . . cord-010119-t1x9gknd 9572 1 Study Study NNP cord-010119-t1x9gknd 9572 2 Design Design NNP cord-010119-t1x9gknd 9572 3 / / SYM cord-010119-t1x9gknd 9572 4 Method method NN cord-010119-t1x9gknd 9572 5 : : : cord-010119-t1x9gknd 9573 1 Pooled pool VBN cord-010119-t1x9gknd 9573 2 plasma plasma NN cord-010119-t1x9gknd 9573 3 sample sample NN cord-010119-t1x9gknd 9573 4 were be VBD cord-010119-t1x9gknd 9573 5 collected collect VBN cord-010119-t1x9gknd 9573 6 from from IN cord-010119-t1x9gknd 9573 7 5,000 5,000 CD cord-010119-t1x9gknd 9573 8 voluntary voluntary JJ cord-010119-t1x9gknd 9573 9 blood blood NN cord-010119-t1x9gknd 9573 10 donors donor NNS cord-010119-t1x9gknd 9573 11 from from IN cord-010119-t1x9gknd 9573 12 Chongqing Chongqing NNP cord-010119-t1x9gknd 9573 13 , , , cord-010119-t1x9gknd 9573 14 China China NNP cord-010119-t1x9gknd 9573 15 . . . cord-010119-t1x9gknd 9574 1 Total total JJ cord-010119-t1x9gknd 9574 2 DNA DNA NNP cord-010119-t1x9gknd 9574 3 and and CC cord-010119-t1x9gknd 9574 4 RNA RNA NNP cord-010119-t1x9gknd 9574 5 were be VBD cord-010119-t1x9gknd 9574 6 extracted extract VBN cord-010119-t1x9gknd 9574 7 and and CC cord-010119-t1x9gknd 9574 8 amplified amplify VBN cord-010119-t1x9gknd 9574 9 with with IN cord-010119-t1x9gknd 9574 10 random random JJ cord-010119-t1x9gknd 9574 11 primers primer NNS cord-010119-t1x9gknd 9574 12 PCR PCR NNP cord-010119-t1x9gknd 9574 13 respectively respectively RB cord-010119-t1x9gknd 9574 14 in in IN cord-010119-t1x9gknd 9574 15 order order NN cord-010119-t1x9gknd 9574 16 to to TO cord-010119-t1x9gknd 9574 17 construct construct VB cord-010119-t1x9gknd 9574 18 a a DT cord-010119-t1x9gknd 9574 19 250PE 250PE NNP cord-010119-t1x9gknd 9574 20 library library NN cord-010119-t1x9gknd 9574 21 to to TO cord-010119-t1x9gknd 9574 22 peform peform VB cord-010119-t1x9gknd 9574 23 deep deep JJ cord-010119-t1x9gknd 9574 24 sequencing sequencing NN cord-010119-t1x9gknd 9574 25 by by IN cord-010119-t1x9gknd 9574 26 Illumina Illumina NNP cord-010119-t1x9gknd 9574 27 Miseq Miseq NNP cord-010119-t1x9gknd 9574 28 . . . cord-010119-t1x9gknd 9575 1 All all DT cord-010119-t1x9gknd 9575 2 reads read NNS cord-010119-t1x9gknd 9575 3 were be VBD cord-010119-t1x9gknd 9575 4 trimmed trim VBN cord-010119-t1x9gknd 9575 5 to to TO cord-010119-t1x9gknd 9575 6 remove remove VB cord-010119-t1x9gknd 9575 7 low low JJ cord-010119-t1x9gknd 9575 8 quality quality NN cord-010119-t1x9gknd 9575 9 bases basis NNS cord-010119-t1x9gknd 9575 10 and and CC cord-010119-t1x9gknd 9575 11 adapter adapter NN cord-010119-t1x9gknd 9575 12 sequences sequence NNS cord-010119-t1x9gknd 9575 13 . . . cord-010119-t1x9gknd 9576 1 The the DT cord-010119-t1x9gknd 9576 2 fully fully RB cord-010119-t1x9gknd 9576 3 overlapping overlap VBG cord-010119-t1x9gknd 9576 4 paired pair VBN cord-010119-t1x9gknd 9576 5 - - HYPH cord-010119-t1x9gknd 9576 6 end end NN cord-010119-t1x9gknd 9576 7 reads read NNS cord-010119-t1x9gknd 9576 8 passing pass VBG cord-010119-t1x9gknd 9576 9 the the DT cord-010119-t1x9gknd 9576 10 quality quality NN cord-010119-t1x9gknd 9576 11 filter filter NN cord-010119-t1x9gknd 9576 12 were be VBD cord-010119-t1x9gknd 9576 13 concatenated concatenate VBN cord-010119-t1x9gknd 9576 14 using use VBG cord-010119-t1x9gknd 9576 15 PEAR PEAR NNP cord-010119-t1x9gknd 9576 16 . . . cord-010119-t1x9gknd 9577 1 We -PRON- PRP cord-010119-t1x9gknd 9577 2 classified classify VBD cord-010119-t1x9gknd 9577 3 the the DT cord-010119-t1x9gknd 9577 4 final final JJ cord-010119-t1x9gknd 9577 5 reads read NNS cord-010119-t1x9gknd 9577 6 using use VBG cord-010119-t1x9gknd 9577 7 Kraken Kraken NNP cord-010119-t1x9gknd 9577 8 and and CC cord-010119-t1x9gknd 9577 9 a a DT cord-010119-t1x9gknd 9577 10 Kraken Kraken NNP cord-010119-t1x9gknd 9577 11 database database NN cord-010119-t1x9gknd 9577 12 made make VBN cord-010119-t1x9gknd 9577 13 from from IN cord-010119-t1x9gknd 9577 14 complete complete JJ cord-010119-t1x9gknd 9577 15 RefSeq RefSeq NNP cord-010119-t1x9gknd 9577 16 bacterial bacterial JJ cord-010119-t1x9gknd 9577 17 , , , cord-010119-t1x9gknd 9577 18 archaeal archaeal JJ cord-010119-t1x9gknd 9577 19 and and CC cord-010119-t1x9gknd 9577 20 viral viral JJ cord-010119-t1x9gknd 9577 21 genomes genome NNS cord-010119-t1x9gknd 9577 22 , , , cord-010119-t1x9gknd 9577 23 along along IN cord-010119-t1x9gknd 9577 24 with with IN cord-010119-t1x9gknd 9577 25 the the DT cord-010119-t1x9gknd 9577 26 GRCh37 GRCh37 NNP cord-010119-t1x9gknd 9577 27 human human JJ cord-010119-t1x9gknd 9577 28 genome genome NN cord-010119-t1x9gknd 9577 29 . . . cord-010119-t1x9gknd 9578 1 The the DT cord-010119-t1x9gknd 9578 2 unclassified unclassified JJ cord-010119-t1x9gknd 9578 3 reads read NNS cord-010119-t1x9gknd 9578 4 by by IN cord-010119-t1x9gknd 9578 5 Kraken Kraken NNP cord-010119-t1x9gknd 9578 6 were be VBD cord-010119-t1x9gknd 9578 7 aligned align VBN cord-010119-t1x9gknd 9578 8 to to IN cord-010119-t1x9gknd 9578 9 NCBI NCBI NNP cord-010119-t1x9gknd 9578 10 nt nt RB cord-010119-t1x9gknd 9578 11 database database NN cord-010119-t1x9gknd 9578 12 using use VBG cord-010119-t1x9gknd 9578 13 BLASTn BLASTn NNS cord-010119-t1x9gknd 9578 14 with with IN cord-010119-t1x9gknd 9578 15 cut cut NN cord-010119-t1x9gknd 9578 16 - - HYPH cord-010119-t1x9gknd 9578 17 off off RP cord-010119-t1x9gknd 9578 18 Evalue Evalue NNP cord-010119-t1x9gknd 9578 19 as as IN cord-010119-t1x9gknd 9578 20 1E 1E NNP cord-010119-t1x9gknd 9578 21 -5 -5 NNP cord-010119-t1x9gknd 9578 22 . . . cord-010119-t1x9gknd 9579 1 The the DT cord-010119-t1x9gknd 9579 2 best good JJS cord-010119-t1x9gknd 9579 3 alignment alignment NN cord-010119-t1x9gknd 9579 4 hits hit NNS cord-010119-t1x9gknd 9579 5 were be VBD cord-010119-t1x9gknd 9579 6 used use VBN cord-010119-t1x9gknd 9579 7 to to TO cord-010119-t1x9gknd 9579 8 classify classify VB cord-010119-t1x9gknd 9579 9 the the DT cord-010119-t1x9gknd 9579 10 reads read NNS cord-010119-t1x9gknd 9579 11 . . . cord-010119-t1x9gknd 9580 1 Krona Krona NNP cord-010119-t1x9gknd 9580 2 was be VBD cord-010119-t1x9gknd 9580 3 used use VBN cord-010119-t1x9gknd 9580 4 to to TO cord-010119-t1x9gknd 9580 5 generate generate VB cord-010119-t1x9gknd 9580 6 all all DT cord-010119-t1x9gknd 9580 7 taxonomic taxonomic JJ cord-010119-t1x9gknd 9580 8 distribution distribution NN cord-010119-t1x9gknd 9580 9 plots plot NNS cord-010119-t1x9gknd 9580 10 . . . cord-010119-t1x9gknd 9581 1 Finally finally RB cord-010119-t1x9gknd 9581 2 , , , cord-010119-t1x9gknd 9581 3 the the DT cord-010119-t1x9gknd 9581 4 potential potential JJ cord-010119-t1x9gknd 9581 5 emerging emerge VBG cord-010119-t1x9gknd 9581 6 and and CC cord-010119-t1x9gknd 9581 7 re re VB cord-010119-t1x9gknd 9581 8 - - JJ cord-010119-t1x9gknd 9581 9 emerging emerge VBG cord-010119-t1x9gknd 9581 10 infectious infectious JJ cord-010119-t1x9gknd 9581 11 pathogens pathogen NNS cord-010119-t1x9gknd 9581 12 were be VBD cord-010119-t1x9gknd 9581 13 identified identify VBN cord-010119-t1x9gknd 9581 14 out out IN cord-010119-t1x9gknd 9581 15 of of IN cord-010119-t1x9gknd 9581 16 the the DT cord-010119-t1x9gknd 9581 17 classified classify VBN cord-010119-t1x9gknd 9581 18 microbiome microbiome NN cord-010119-t1x9gknd 9581 19 by by IN cord-010119-t1x9gknd 9581 20 experience experience NN cord-010119-t1x9gknd 9581 21 . . . cord-010119-t1x9gknd 9582 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 9582 2 Results Results NNP cord-010119-t1x9gknd 9582 3 / / SYM cord-010119-t1x9gknd 9582 4 Finding finding NN cord-010119-t1x9gknd 9582 5 : : : cord-010119-t1x9gknd 9582 6 1.23 1.23 CD cord-010119-t1x9gknd 9582 7 GB GB NNP cord-010119-t1x9gknd 9582 8 raw raw JJ cord-010119-t1x9gknd 9582 9 data datum NNS cord-010119-t1x9gknd 9582 10 with with IN cord-010119-t1x9gknd 9582 11 2,450,046 2,450,046 CD cord-010119-t1x9gknd 9582 12 reads read NNS cord-010119-t1x9gknd 9582 13 were be VBD cord-010119-t1x9gknd 9582 14 generated generate VBN cord-010119-t1x9gknd 9582 15 in in IN cord-010119-t1x9gknd 9582 16 the the DT cord-010119-t1x9gknd 9582 17 DNA dna NN cord-010119-t1x9gknd 9582 18 library library NN cord-010119-t1x9gknd 9582 19 . . . cord-010119-t1x9gknd 9583 1 Meanwhile meanwhile RB cord-010119-t1x9gknd 9583 2 , , , cord-010119-t1x9gknd 9583 3 1.98 1.98 CD cord-010119-t1x9gknd 9583 4 GB GB NNP cord-010119-t1x9gknd 9583 5 raw raw JJ cord-010119-t1x9gknd 9583 6 data datum NNS cord-010119-t1x9gknd 9583 7 with with IN cord-010119-t1x9gknd 9583 8 3,967,242 3,967,242 CD cord-010119-t1x9gknd 9583 9 reads read NNS cord-010119-t1x9gknd 9583 10 were be VBD cord-010119-t1x9gknd 9583 11 generated generate VBN cord-010119-t1x9gknd 9583 12 in in IN cord-010119-t1x9gknd 9583 13 the the DT cord-010119-t1x9gknd 9583 14 RNA RNA NNP cord-010119-t1x9gknd 9583 15 library library NN cord-010119-t1x9gknd 9583 16 . . . cord-010119-t1x9gknd 9584 1 After after IN cord-010119-t1x9gknd 9584 2 cleaning clean VBG cord-010119-t1x9gknd 9584 3 the the DT cord-010119-t1x9gknd 9584 4 human human JJ cord-010119-t1x9gknd 9584 5 background background NN cord-010119-t1x9gknd 9584 6 , , , cord-010119-t1x9gknd 9584 7 211 211 CD cord-010119-t1x9gknd 9584 8 reads read VBZ cord-010119-t1x9gknd 9584 9 from from IN cord-010119-t1x9gknd 9584 10 bacteria bacteria NNS cord-010119-t1x9gknd 9584 11 , , , cord-010119-t1x9gknd 9584 12 98 98 CD cord-010119-t1x9gknd 9584 13 reads read VBZ cord-010119-t1x9gknd 9584 14 from from IN cord-010119-t1x9gknd 9584 15 viruses virus NNS cord-010119-t1x9gknd 9584 16 , , , cord-010119-t1x9gknd 9584 17 and and CC cord-010119-t1x9gknd 9584 18 341 341 CD cord-010119-t1x9gknd 9584 19 reads read VBZ cord-010119-t1x9gknd 9584 20 from from IN cord-010119-t1x9gknd 9584 21 parasites parasite NNS cord-010119-t1x9gknd 9584 22 were be VBD cord-010119-t1x9gknd 9584 23 identified identify VBN cord-010119-t1x9gknd 9584 24 ( ( -LRB- cord-010119-t1x9gknd 9584 25 Table table NN cord-010119-t1x9gknd 9584 26 1 1 CD cord-010119-t1x9gknd 9584 27 ) ) -RRB- cord-010119-t1x9gknd 9584 28 . . . cord-010119-t1x9gknd 9585 1 No no DT cord-010119-t1x9gknd 9585 2 hazardous hazardous JJ cord-010119-t1x9gknd 9585 3 viruses virus NNS cord-010119-t1x9gknd 9585 4 were be VBD cord-010119-t1x9gknd 9585 5 identified identify VBN cord-010119-t1x9gknd 9585 6 as as IN cord-010119-t1x9gknd 9585 7 potential potential JJ cord-010119-t1x9gknd 9585 8 threats threat NNS cord-010119-t1x9gknd 9585 9 to to IN cord-010119-t1x9gknd 9585 10 blood blood NN cord-010119-t1x9gknd 9585 11 safety safety NN cord-010119-t1x9gknd 9585 12 . . . cord-010119-t1x9gknd 9586 1 Except except IN cord-010119-t1x9gknd 9586 2 for for IN cord-010119-t1x9gknd 9586 3 viruses virus NNS cord-010119-t1x9gknd 9586 4 and and CC cord-010119-t1x9gknd 9586 5 bacterias bacteria NNS cord-010119-t1x9gknd 9586 6 which which WDT cord-010119-t1x9gknd 9586 7 would would MD cord-010119-t1x9gknd 9586 8 do do VB cord-010119-t1x9gknd 9586 9 limited limited JJ cord-010119-t1x9gknd 9586 10 hazards hazard NNS cord-010119-t1x9gknd 9586 11 to to IN cord-010119-t1x9gknd 9586 12 blood blood NN cord-010119-t1x9gknd 9586 13 safety safety NN cord-010119-t1x9gknd 9586 14 , , , cord-010119-t1x9gknd 9586 15 plenty plenty NN cord-010119-t1x9gknd 9586 16 of of IN cord-010119-t1x9gknd 9586 17 parasites parasite NNS cord-010119-t1x9gknd 9586 18 were be VBD cord-010119-t1x9gknd 9586 19 identified identify VBN cord-010119-t1x9gknd 9586 20 in in IN cord-010119-t1x9gknd 9586 21 which which WDT cord-010119-t1x9gknd 9586 22 some some DT cord-010119-t1x9gknd 9586 23 were be VBD cord-010119-t1x9gknd 9586 24 already already RB cord-010119-t1x9gknd 9586 25 considered consider VBN cord-010119-t1x9gknd 9586 26 as as IN cord-010119-t1x9gknd 9586 27 threats threat NNS cord-010119-t1x9gknd 9586 28 to to IN cord-010119-t1x9gknd 9586 29 blood blood NN cord-010119-t1x9gknd 9586 30 safety safety NN cord-010119-t1x9gknd 9586 31 in in IN cord-010119-t1x9gknd 9586 32 some some DT cord-010119-t1x9gknd 9586 33 developed develop VBN cord-010119-t1x9gknd 9586 34 countries country NNS cord-010119-t1x9gknd 9586 35 were be VBD cord-010119-t1x9gknd 9586 36 also also RB cord-010119-t1x9gknd 9586 37 discovered discover VBN cord-010119-t1x9gknd 9586 38 such such JJ cord-010119-t1x9gknd 9586 39 as as IN cord-010119-t1x9gknd 9586 40 Plasmodium Plasmodium NNP cord-010119-t1x9gknd 9586 41 sp sp NN cord-010119-t1x9gknd 9586 42 . . . cord-010119-t1x9gknd 9587 1 and and CC cord-010119-t1x9gknd 9587 2 Leishmania Leishmania NNP cord-010119-t1x9gknd 9587 3 infantum infantum NN cord-010119-t1x9gknd 9587 4 ( ( -LRB- cord-010119-t1x9gknd 9587 5 Table table NN cord-010119-t1x9gknd 9587 6 1 1 CD cord-010119-t1x9gknd 9587 7 ) ) -RRB- cord-010119-t1x9gknd 9587 8 . . . cord-010119-t1x9gknd 9588 1 Conclusion conclusion NN cord-010119-t1x9gknd 9588 2 : : : cord-010119-t1x9gknd 9589 1 The the DT cord-010119-t1x9gknd 9589 2 investigation investigation NN cord-010119-t1x9gknd 9589 3 has have VBZ cord-010119-t1x9gknd 9589 4 revealed reveal VBN cord-010119-t1x9gknd 9589 5 the the DT cord-010119-t1x9gknd 9589 6 metagenomics metagenomic NNS cord-010119-t1x9gknd 9589 7 of of IN cord-010119-t1x9gknd 9589 8 the the DT cord-010119-t1x9gknd 9589 9 qualified qualified JJ cord-010119-t1x9gknd 9589 10 blood blood NN cord-010119-t1x9gknd 9589 11 donations donation NNS cord-010119-t1x9gknd 9589 12 in in IN cord-010119-t1x9gknd 9589 13 Chongqing Chongqing NNP cord-010119-t1x9gknd 9589 14 , , , cord-010119-t1x9gknd 9589 15 China China NNP cord-010119-t1x9gknd 9589 16 . . . cord-010119-t1x9gknd 9590 1 The the DT cord-010119-t1x9gknd 9590 2 results result NNS cord-010119-t1x9gknd 9590 3 showed show VBD cord-010119-t1x9gknd 9590 4 a a DT cord-010119-t1x9gknd 9590 5 thoughprovoking thoughprovoking NN cord-010119-t1x9gknd 9590 6 discovery discovery NN cord-010119-t1x9gknd 9590 7 of of IN cord-010119-t1x9gknd 9590 8 genomic genomic JJ cord-010119-t1x9gknd 9590 9 fragments fragment NNS cord-010119-t1x9gknd 9590 10 of of IN cord-010119-t1x9gknd 9590 11 some some DT cord-010119-t1x9gknd 9590 12 microbes microbe NNS cord-010119-t1x9gknd 9590 13 which which WDT cord-010119-t1x9gknd 9590 14 might may MD cord-010119-t1x9gknd 9590 15 threat threat VB cord-010119-t1x9gknd 9590 16 the the DT cord-010119-t1x9gknd 9590 17 blood blood NN cord-010119-t1x9gknd 9590 18 safety safety NN cord-010119-t1x9gknd 9590 19 . . . cord-010119-t1x9gknd 9591 1 The the DT cord-010119-t1x9gknd 9591 2 displayed display VBN cord-010119-t1x9gknd 9591 3 serious serious JJ cord-010119-t1x9gknd 9591 4 results result NNS cord-010119-t1x9gknd 9591 5 let let VBP cord-010119-t1x9gknd 9591 6 us -PRON- PRP cord-010119-t1x9gknd 9591 7 have have VB cord-010119-t1x9gknd 9591 8 to to TO cord-010119-t1x9gknd 9591 9 think think VB cord-010119-t1x9gknd 9591 10 about about IN cord-010119-t1x9gknd 9591 11 regulating regulate VBG cord-010119-t1x9gknd 9591 12 some some DT cord-010119-t1x9gknd 9591 13 reasonable reasonable JJ cord-010119-t1x9gknd 9591 14 screening screening NN cord-010119-t1x9gknd 9591 15 methods method NNS cord-010119-t1x9gknd 9591 16 as as RB cord-010119-t1x9gknd 9591 17 well well RB cord-010119-t1x9gknd 9591 18 as as IN cord-010119-t1x9gknd 9591 19 donor donor NN cord-010119-t1x9gknd 9591 20 recruitment recruitment NN cord-010119-t1x9gknd 9591 21 strategy strategy NN cord-010119-t1x9gknd 9591 22 in in IN cord-010119-t1x9gknd 9591 23 certain certain JJ cord-010119-t1x9gknd 9591 24 epidemic epidemic NN cord-010119-t1x9gknd 9591 25 areas area NNS cord-010119-t1x9gknd 9591 26 or or CC cord-010119-t1x9gknd 9591 27 seasons season NNS cord-010119-t1x9gknd 9591 28 to to TO cord-010119-t1x9gknd 9591 29 ensure ensure VB cord-010119-t1x9gknd 9591 30 the the DT cord-010119-t1x9gknd 9591 31 blood blood NN cord-010119-t1x9gknd 9591 32 safety safety NN cord-010119-t1x9gknd 9591 33 . . . cord-010119-t1x9gknd 9592 1 However however RB cord-010119-t1x9gknd 9592 2 , , , cord-010119-t1x9gknd 9592 3 on on IN cord-010119-t1x9gknd 9592 4 the the DT cord-010119-t1x9gknd 9592 5 contrary contrary NN cord-010119-t1x9gknd 9592 6 , , , cord-010119-t1x9gknd 9592 7 the the DT cord-010119-t1x9gknd 9592 8 results result NNS cord-010119-t1x9gknd 9592 9 should should MD cord-010119-t1x9gknd 9592 10 be be VB cord-010119-t1x9gknd 9592 11 considered consider VBN cord-010119-t1x9gknd 9592 12 more more RBR cord-010119-t1x9gknd 9592 13 cautiously cautiously RB cord-010119-t1x9gknd 9592 14 because because IN cord-010119-t1x9gknd 9592 15 the the DT cord-010119-t1x9gknd 9592 16 existing existing NN cord-010119-t1x9gknd 9592 17 of of IN cord-010119-t1x9gknd 9592 18 genomic genomic JJ cord-010119-t1x9gknd 9592 19 fragments fragment NNS cord-010119-t1x9gknd 9592 20 could could MD cord-010119-t1x9gknd 9592 21 not not RB cord-010119-t1x9gknd 9592 22 represent represent VB cord-010119-t1x9gknd 9592 23 the the DT cord-010119-t1x9gknd 9592 24 existing existing NN cord-010119-t1x9gknd 9592 25 of of IN cord-010119-t1x9gknd 9592 26 infectious infectious JJ cord-010119-t1x9gknd 9592 27 pathogens pathogen NNS cord-010119-t1x9gknd 9592 28 . . . cord-010119-t1x9gknd 9593 1 The the DT cord-010119-t1x9gknd 9593 2 validity validity NN cord-010119-t1x9gknd 9593 3 of of IN cord-010119-t1x9gknd 9593 4 the the DT cord-010119-t1x9gknd 9593 5 metagenomics metagenomic NNS cord-010119-t1x9gknd 9593 6 hints hint NNS cord-010119-t1x9gknd 9593 7 were be VBD cord-010119-t1x9gknd 9593 8 suggested suggest VBN cord-010119-t1x9gknd 9593 9 to to TO cord-010119-t1x9gknd 9593 10 go go VB cord-010119-t1x9gknd 9593 11 through through IN cord-010119-t1x9gknd 9593 12 epidemiological epidemiological JJ cord-010119-t1x9gknd 9593 13 investigations investigation NNS cord-010119-t1x9gknd 9593 14 and and CC cord-010119-t1x9gknd 9593 15 specifically specifically RB cord-010119-t1x9gknd 9593 16 tested test VBN cord-010119-t1x9gknd 9593 17 under under IN cord-010119-t1x9gknd 9593 18 laboratory laboratory NN cord-010119-t1x9gknd 9593 19 ways way NNS cord-010119-t1x9gknd 9593 20 such such JJ cord-010119-t1x9gknd 9593 21 as as IN cord-010119-t1x9gknd 9593 22 bacteria bacteria NNS cord-010119-t1x9gknd 9593 23 or or CC cord-010119-t1x9gknd 9593 24 virus virus NN cord-010119-t1x9gknd 9593 25 culturing culture VBG cord-010119-t1x9gknd 9593 26 to to TO cord-010119-t1x9gknd 9593 27 ensure ensure VB cord-010119-t1x9gknd 9593 28 the the DT cord-010119-t1x9gknd 9593 29 vitality vitality NN cord-010119-t1x9gknd 9593 30 of of IN cord-010119-t1x9gknd 9593 31 those those DT cord-010119-t1x9gknd 9593 32 pathogens pathogen NNS cord-010119-t1x9gknd 9593 33 . . . cord-010119-t1x9gknd 9594 1 Background Background NNP cord-010119-t1x9gknd 9594 2 / / SYM cord-010119-t1x9gknd 9594 3 Case Case NNP cord-010119-t1x9gknd 9594 4 Studies Studies NNPS cord-010119-t1x9gknd 9594 5 : : : cord-010119-t1x9gknd 9595 1 The the DT cord-010119-t1x9gknd 9595 2 Caribbean Caribbean NNP cord-010119-t1x9gknd 9595 3 has have VBZ cord-010119-t1x9gknd 9595 4 become become VBN cord-010119-t1x9gknd 9595 5 an an DT cord-010119-t1x9gknd 9595 6 endemic endemic JJ cord-010119-t1x9gknd 9595 7 region region NN cord-010119-t1x9gknd 9595 8 for for IN cord-010119-t1x9gknd 9595 9 several several JJ cord-010119-t1x9gknd 9595 10 emerging emerge VBG cord-010119-t1x9gknd 9595 11 viruses virus NNS cord-010119-t1x9gknd 9595 12 in in IN cord-010119-t1x9gknd 9595 13 the the DT cord-010119-t1x9gknd 9595 14 last last JJ cord-010119-t1x9gknd 9595 15 decade decade NN cord-010119-t1x9gknd 9595 16 . . . cord-010119-t1x9gknd 9596 1 After after IN cord-010119-t1x9gknd 9596 2 a a DT cord-010119-t1x9gknd 9596 3 Chikungunya Chikungunya NNP cord-010119-t1x9gknd 9596 4 outbreak outbreak NN cord-010119-t1x9gknd 9596 5 in in IN cord-010119-t1x9gknd 9596 6 2015 2015 CD cord-010119-t1x9gknd 9596 7 most most RBS cord-010119-t1x9gknd 9596 8 recently recently RB cord-010119-t1x9gknd 9596 9 Zika Zika NNP cord-010119-t1x9gknd 9596 10 was be VBD cord-010119-t1x9gknd 9596 11 shown show VBN cord-010119-t1x9gknd 9596 12 to to TO cord-010119-t1x9gknd 9596 13 be be VB cord-010119-t1x9gknd 9596 14 endemic endemic JJ cord-010119-t1x9gknd 9596 15 on on IN cord-010119-t1x9gknd 9596 16 the the DT cord-010119-t1x9gknd 9596 17 Caribbean caribbean JJ cord-010119-t1x9gknd 9596 18 island island NN cord-010119-t1x9gknd 9596 19 of of IN cord-010119-t1x9gknd 9596 20 Curacao Curacao NNP cord-010119-t1x9gknd 9596 21 . . . cord-010119-t1x9gknd 9597 1 To to TO cord-010119-t1x9gknd 9597 2 effectively effectively RB cord-010119-t1x9gknd 9597 3 provide provide VB cord-010119-t1x9gknd 9597 4 safe safe JJ cord-010119-t1x9gknd 9597 5 blood blood NN cord-010119-t1x9gknd 9597 6 products product NNS cord-010119-t1x9gknd 9597 7 in in IN cord-010119-t1x9gknd 9597 8 an an DT cord-010119-t1x9gknd 9597 9 endemic endemic JJ cord-010119-t1x9gknd 9597 10 region region NN cord-010119-t1x9gknd 9597 11 the the DT cord-010119-t1x9gknd 9597 12 conventional conventional JJ cord-010119-t1x9gknd 9597 13 international international JJ cord-010119-t1x9gknd 9597 14 recommendations recommendation NNS cord-010119-t1x9gknd 9597 15 of of IN cord-010119-t1x9gknd 9597 16 donor donor NN cord-010119-t1x9gknd 9597 17 exclusion exclusion NN cord-010119-t1x9gknd 9597 18 and and CC cord-010119-t1x9gknd 9597 19 testing testing NN cord-010119-t1x9gknd 9597 20 do do VBP cord-010119-t1x9gknd 9597 21 not not RB cord-010119-t1x9gknd 9597 22 seem seem VB cord-010119-t1x9gknd 9597 23 a a DT cord-010119-t1x9gknd 9597 24 viable viable JJ cord-010119-t1x9gknd 9597 25 option option NN cord-010119-t1x9gknd 9597 26 and and CC cord-010119-t1x9gknd 9597 27 could could MD cord-010119-t1x9gknd 9597 28 severely severely RB cord-010119-t1x9gknd 9597 29 affect affect VB cord-010119-t1x9gknd 9597 30 the the DT cord-010119-t1x9gknd 9597 31 local local JJ cord-010119-t1x9gknd 9597 32 blood blood NN cord-010119-t1x9gknd 9597 33 supply supply NN cord-010119-t1x9gknd 9597 34 . . . cord-010119-t1x9gknd 9598 1 Pathogen pathogen NN cord-010119-t1x9gknd 9598 2 reduction reduction NN cord-010119-t1x9gknd 9598 3 ( ( -LRB- cord-010119-t1x9gknd 9598 4 PR PR NNP cord-010119-t1x9gknd 9598 5 ) ) -RRB- cord-010119-t1x9gknd 9598 6 is be VBZ cord-010119-t1x9gknd 9598 7 considered consider VBN cord-010119-t1x9gknd 9598 8 an an DT cord-010119-t1x9gknd 9598 9 important important JJ cord-010119-t1x9gknd 9598 10 new new JJ cord-010119-t1x9gknd 9598 11 approach approach NN cord-010119-t1x9gknd 9598 12 with with IN cord-010119-t1x9gknd 9598 13 potential potential JJ cord-010119-t1x9gknd 9598 14 benefits benefit NNS cord-010119-t1x9gknd 9598 15 . . . cord-010119-t1x9gknd 9599 1 The the DT cord-010119-t1x9gknd 9599 2 introduction introduction NN cord-010119-t1x9gknd 9599 3 and and CC cord-010119-t1x9gknd 9599 4 experience experience NN cord-010119-t1x9gknd 9599 5 of of IN cord-010119-t1x9gknd 9599 6 use use NN cord-010119-t1x9gknd 9599 7 of of IN cord-010119-t1x9gknd 9599 8 PR PR NNP cord-010119-t1x9gknd 9599 9 platelets platelet NNS cord-010119-t1x9gknd 9599 10 in in IN cord-010119-t1x9gknd 9599 11 the the DT cord-010119-t1x9gknd 9599 12 Dutch Dutch NNP cord-010119-t1x9gknd 9599 13 Caribbean Caribbean NNP cord-010119-t1x9gknd 9599 14 over over IN cord-010119-t1x9gknd 9599 15 a a DT cord-010119-t1x9gknd 9599 16 period period NN cord-010119-t1x9gknd 9599 17 of of IN cord-010119-t1x9gknd 9599 18 one one CD cord-010119-t1x9gknd 9599 19 year year NN cord-010119-t1x9gknd 9599 20 is be VBZ cord-010119-t1x9gknd 9599 21 presented present VBN cord-010119-t1x9gknd 9599 22 . . . cord-010119-t1x9gknd 9600 1 Study Study NNP cord-010119-t1x9gknd 9600 2 Design Design NNP cord-010119-t1x9gknd 9600 3 / / SYM cord-010119-t1x9gknd 9600 4 Method method NN cord-010119-t1x9gknd 9600 5 : : : cord-010119-t1x9gknd 9601 1 Pathogen pathogen NN cord-010119-t1x9gknd 9601 2 reduction reduction NN cord-010119-t1x9gknd 9601 3 of of IN cord-010119-t1x9gknd 9601 4 thrombocyte thrombocyte NN cord-010119-t1x9gknd 9601 5 concentrates concentrate VBZ cord-010119-t1x9gknd 9601 6 by by IN cord-010119-t1x9gknd 9601 7 use use NN cord-010119-t1x9gknd 9601 8 of of IN cord-010119-t1x9gknd 9601 9 riboflavin riboflavin NN cord-010119-t1x9gknd 9601 10 and and CC cord-010119-t1x9gknd 9601 11 ultraviolet ultraviolet NN cord-010119-t1x9gknd 9601 12 treatment treatment NN cord-010119-t1x9gknd 9601 13 ( ( -LRB- cord-010119-t1x9gknd 9601 14 Mirasol Mirasol NNP cord-010119-t1x9gknd 9601 15 PRT PRT NNP cord-010119-t1x9gknd 9601 16 , , , cord-010119-t1x9gknd 9601 17 Terumo Terumo NNP cord-010119-t1x9gknd 9601 18 , , , cord-010119-t1x9gknd 9601 19 Belgium Belgium NNP cord-010119-t1x9gknd 9601 20 ) ) -RRB- cord-010119-t1x9gknd 9601 21 was be VBD cord-010119-t1x9gknd 9601 22 introduced introduce VBN cord-010119-t1x9gknd 9601 23 . . . cord-010119-t1x9gknd 9602 1 All all DT cord-010119-t1x9gknd 9602 2 thrombocyte thrombocyte NNP cord-010119-t1x9gknd 9602 3 concentrates concentrate VBZ cord-010119-t1x9gknd 9602 4 provided provide VBN cord-010119-t1x9gknd 9602 5 to to IN cord-010119-t1x9gknd 9602 6 the the DT cord-010119-t1x9gknd 9602 7 general general JJ cord-010119-t1x9gknd 9602 8 hospitals hospital NNS cord-010119-t1x9gknd 9602 9 on on IN cord-010119-t1x9gknd 9602 10 the the DT cord-010119-t1x9gknd 9602 11 Dutch dutch JJ cord-010119-t1x9gknd 9602 12 Caribbean caribbean JJ cord-010119-t1x9gknd 9602 13 islands island NNS cord-010119-t1x9gknd 9602 14 of of IN cord-010119-t1x9gknd 9602 15 Curaçao Curaçao NNP cord-010119-t1x9gknd 9602 16 , , , cord-010119-t1x9gknd 9602 17 Bonaire Bonaire NNP cord-010119-t1x9gknd 9602 18 and and CC cord-010119-t1x9gknd 9602 19 Sint Sint NNP cord-010119-t1x9gknd 9602 20 Maarten Maarten NNP cord-010119-t1x9gknd 9602 21 were be VBD cord-010119-t1x9gknd 9602 22 PR PR NNP cord-010119-t1x9gknd 9602 23 and and CC cord-010119-t1x9gknd 9602 24 data datum NNS cord-010119-t1x9gknd 9602 25 collected collect VBN cord-010119-t1x9gknd 9602 26 over over IN cord-010119-t1x9gknd 9602 27 the the DT cord-010119-t1x9gknd 9602 28 period period NN cord-010119-t1x9gknd 9602 29 of of IN cord-010119-t1x9gknd 9602 30 1 1 CD cord-010119-t1x9gknd 9602 31 February February NNP cord-010119-t1x9gknd 9602 32 2016 2016 CD cord-010119-t1x9gknd 9602 33 to to IN cord-010119-t1x9gknd 9602 34 1 1 CD cord-010119-t1x9gknd 9602 35 February February NNP cord-010119-t1x9gknd 9602 36 2017 2017 CD cord-010119-t1x9gknd 9602 37 . . . cord-010119-t1x9gknd 9603 1 Thrombocyte Thrombocyte NNP cord-010119-t1x9gknd 9603 2 concentrates concentrate NNS cord-010119-t1x9gknd 9603 3 are be VBP cord-010119-t1x9gknd 9603 4 prepared prepare VBN cord-010119-t1x9gknd 9603 5 out out IN cord-010119-t1x9gknd 9603 6 of of IN cord-010119-t1x9gknd 9603 7 4 4 CD cord-010119-t1x9gknd 9603 8 single single JJ cord-010119-t1x9gknd 9603 9 donation donation NN cord-010119-t1x9gknd 9603 10 units unit NNS cord-010119-t1x9gknd 9603 11 by by IN cord-010119-t1x9gknd 9603 12 the the DT cord-010119-t1x9gknd 9603 13 buffycoat buffycoat NNP cord-010119-t1x9gknd 9603 14 method method NN cord-010119-t1x9gknd 9603 15 . . . cord-010119-t1x9gknd 9604 1 Results/ Results/ . cord-010119-t1x9gknd 9605 1 Finding finding NN cord-010119-t1x9gknd 9605 2 : : : cord-010119-t1x9gknd 9606 1 Over over IN cord-010119-t1x9gknd 9606 2 the the DT cord-010119-t1x9gknd 9606 3 period period NN cord-010119-t1x9gknd 9606 4 260 260 CD cord-010119-t1x9gknd 9606 5 platelet platelet NN cord-010119-t1x9gknd 9606 6 concentrates concentrate NNS cord-010119-t1x9gknd 9606 7 were be VBD cord-010119-t1x9gknd 9606 8 provided provide VBN cord-010119-t1x9gknd 9606 9 to to IN cord-010119-t1x9gknd 9606 10 adult adult NN cord-010119-t1x9gknd 9606 11 and and CC cord-010119-t1x9gknd 9606 12 pediatric pediatric JJ cord-010119-t1x9gknd 9606 13 patients patient NNS cord-010119-t1x9gknd 9606 14 . . . cord-010119-t1x9gknd 9607 1 These these DT cord-010119-t1x9gknd 9607 2 included include VBD cord-010119-t1x9gknd 9607 3 patients patient NNS cord-010119-t1x9gknd 9607 4 on on IN cord-010119-t1x9gknd 9607 5 the the DT cord-010119-t1x9gknd 9607 6 intensive intensive JJ cord-010119-t1x9gknd 9607 7 care care NN cord-010119-t1x9gknd 9607 8 and and CC cord-010119-t1x9gknd 9607 9 neonatal neonatal JJ cord-010119-t1x9gknd 9607 10 intensive intensive JJ cord-010119-t1x9gknd 9607 11 care care NN cord-010119-t1x9gknd 9607 12 departments department NNS cord-010119-t1x9gknd 9607 13 . . . cord-010119-t1x9gknd 9608 1 No no DT cord-010119-t1x9gknd 9608 2 adverse adverse JJ cord-010119-t1x9gknd 9608 3 events event NNS cord-010119-t1x9gknd 9608 4 were be VBD cord-010119-t1x9gknd 9608 5 reported report VBN cord-010119-t1x9gknd 9608 6 and and CC cord-010119-t1x9gknd 9608 7 the the DT cord-010119-t1x9gknd 9608 8 CCI CCI NNP cord-010119-t1x9gknd 9608 9 for for IN cord-010119-t1x9gknd 9608 10 each each DT cord-010119-t1x9gknd 9608 11 transfusion transfusion NN cord-010119-t1x9gknd 9608 12 was be VBD cord-010119-t1x9gknd 9608 13 within within IN cord-010119-t1x9gknd 9608 14 the the DT cord-010119-t1x9gknd 9608 15 expected expect VBN cord-010119-t1x9gknd 9608 16 outcome outcome NN cord-010119-t1x9gknd 9608 17 . . . cord-010119-t1x9gknd 9609 1 Introduction introduction NN cord-010119-t1x9gknd 9609 2 of of IN cord-010119-t1x9gknd 9609 3 PR PR NNP cord-010119-t1x9gknd 9609 4 had have VBD cord-010119-t1x9gknd 9609 5 minimal minimal JJ cord-010119-t1x9gknd 9609 6 impact impact NN cord-010119-t1x9gknd 9609 7 on on IN cord-010119-t1x9gknd 9609 8 the the DT cord-010119-t1x9gknd 9609 9 logistics logistic NNS cord-010119-t1x9gknd 9609 10 of of IN cord-010119-t1x9gknd 9609 11 thrombocyte thrombocyte NNP cord-010119-t1x9gknd 9609 12 concentrate concentrate VBP cord-010119-t1x9gknd 9609 13 preparation preparation NN cord-010119-t1x9gknd 9609 14 and and CC cord-010119-t1x9gknd 9609 15 availability availability NN cord-010119-t1x9gknd 9609 16 . . . cord-010119-t1x9gknd 9610 1 Furthermore furthermore RB cord-010119-t1x9gknd 9610 2 no no DT cord-010119-t1x9gknd 9610 3 transfusion transfusion NN cord-010119-t1x9gknd 9610 4 related relate VBN cord-010119-t1x9gknd 9610 5 bacterial bacterial JJ cord-010119-t1x9gknd 9610 6 contaminations contamination NNS cord-010119-t1x9gknd 9610 7 were be VBD cord-010119-t1x9gknd 9610 8 reported report VBN cord-010119-t1x9gknd 9610 9 . . . cord-010119-t1x9gknd 9611 1 Conclusion conclusion NN cord-010119-t1x9gknd 9611 2 : : : cord-010119-t1x9gknd 9612 1 PR PR NNP cord-010119-t1x9gknd 9612 2 of of IN cord-010119-t1x9gknd 9612 3 platelet platelet NN cord-010119-t1x9gknd 9612 4 concentrates concentrate VBZ cord-010119-t1x9gknd 9612 5 seems seem VBZ cord-010119-t1x9gknd 9612 6 viable viable JJ cord-010119-t1x9gknd 9612 7 and and CC cord-010119-t1x9gknd 9612 8 safe safe JJ cord-010119-t1x9gknd 9612 9 for for IN cord-010119-t1x9gknd 9612 10 use use NN cord-010119-t1x9gknd 9612 11 in in IN cord-010119-t1x9gknd 9612 12 a a DT cord-010119-t1x9gknd 9612 13 small small JJ cord-010119-t1x9gknd 9612 14 scale scale NN cord-010119-t1x9gknd 9612 15 Caribbean Caribbean NNP cord-010119-t1x9gknd 9612 16 setting set VBG cord-010119-t1x9gknd 9612 17 with with IN cord-010119-t1x9gknd 9612 18 endemicity endemicity NN cord-010119-t1x9gknd 9612 19 for for IN cord-010119-t1x9gknd 9612 20 emerging emerge VBG cord-010119-t1x9gknd 9612 21 viruses virus NNS cord-010119-t1x9gknd 9612 22 like like IN cord-010119-t1x9gknd 9612 23 Chikungunya Chikungunya NNP cord-010119-t1x9gknd 9612 24 and and CC cord-010119-t1x9gknd 9612 25 Zika Zika NNP cord-010119-t1x9gknd 9612 26 . . . cord-010119-t1x9gknd 9613 1 It -PRON- PRP cord-010119-t1x9gknd 9613 2 offers offer VBZ cord-010119-t1x9gknd 9613 3 a a DT cord-010119-t1x9gknd 9613 4 realistic realistic JJ cord-010119-t1x9gknd 9613 5 alternative alternative NN cord-010119-t1x9gknd 9613 6 for for IN cord-010119-t1x9gknd 9613 7 conventional conventional JJ cord-010119-t1x9gknd 9613 8 recommendations recommendation NNS cord-010119-t1x9gknd 9613 9 of of IN cord-010119-t1x9gknd 9613 10 donor donor NN cord-010119-t1x9gknd 9613 11 exclusion exclusion NN cord-010119-t1x9gknd 9613 12 and and CC cord-010119-t1x9gknd 9613 13 testing testing NN cord-010119-t1x9gknd 9613 14 , , , cord-010119-t1x9gknd 9613 15 thereby thereby RB cord-010119-t1x9gknd 9613 16 helping help VBG cord-010119-t1x9gknd 9613 17 to to TO cord-010119-t1x9gknd 9613 18 maintain maintain VB cord-010119-t1x9gknd 9613 19 sufficient sufficient JJ cord-010119-t1x9gknd 9613 20 labile labile JJ cord-010119-t1x9gknd 9613 21 blood blood NN cord-010119-t1x9gknd 9613 22 product product NN cord-010119-t1x9gknd 9613 23 availability availability NN cord-010119-t1x9gknd 9613 24 . . . cord-010119-t1x9gknd 9614 1 Michael Michael NNP cord-010119-t1x9gknd 9614 2 Phillips Phillips NNP cord-010119-t1x9gknd 9614 3 * * NFP cord-010119-t1x9gknd 9614 4 1 1 CD cord-010119-t1x9gknd 9614 5 , , , cord-010119-t1x9gknd 9614 6 Germ Germ NNP cord-010119-t1x9gknd 9614 7 an an DT cord-010119-t1x9gknd 9614 8 Leparc Leparc NNP cord-010119-t1x9gknd 9614 9 2 2 CD cord-010119-t1x9gknd 9614 10 , , , cord-010119-t1x9gknd 9614 11 Phillip Phillip NNP cord-010119-t1x9gknd 9614 12 C C NNP cord-010119-t1x9gknd 9614 13 Williamson Williamson NNP cord-010119-t1x9gknd 9614 14 1 1 CD cord-010119-t1x9gknd 9614 15 , , , cord-010119-t1x9gknd 9614 16 Lani Lani NNP cord-010119-t1x9gknd 9614 17 Palmer Palmer NNP cord-010119-t1x9gknd 9614 18 1 1 CD cord-010119-t1x9gknd 9614 19 , , , cord-010119-t1x9gknd 9614 20 Ben Ben NNP cord-010119-t1x9gknd 9614 21 Reynolds Reynolds NNP cord-010119-t1x9gknd 9614 22 1 1 CD cord-010119-t1x9gknd 9614 23 , , , cord-010119-t1x9gknd 9614 24 Maria Maria NNP cord-010119-t1x9gknd 9614 25 Noedel Noedel NNP cord-010119-t1x9gknd 9614 26 1 1 CD cord-010119-t1x9gknd 9614 27 and and CC cord-010119-t1x9gknd 9614 28 Lindsey Lindsey NNP cord-010119-t1x9gknd 9614 29 Houghton Houghton NNP cord-010119-t1x9gknd 9614 30 1 1 CD cord-010119-t1x9gknd 9614 31 . . . cord-010119-t1x9gknd 9615 1 1 1 LS cord-010119-t1x9gknd 9615 2 Creative Creative NNP cord-010119-t1x9gknd 9615 3 Testing Testing NNP cord-010119-t1x9gknd 9615 4 Solutions Solutions NNPS cord-010119-t1x9gknd 9615 5 , , , cord-010119-t1x9gknd 9615 6 2 2 CD cord-010119-t1x9gknd 9615 7 OneBlood OneBlood NNP cord-010119-t1x9gknd 9615 8 Background Background NNP cord-010119-t1x9gknd 9615 9 / / SYM cord-010119-t1x9gknd 9615 10 Case Case NNP cord-010119-t1x9gknd 9615 11 Studies Studies NNPS cord-010119-t1x9gknd 9615 12 : : : cord-010119-t1x9gknd 9615 13 Due due IN cord-010119-t1x9gknd 9615 14 to to IN cord-010119-t1x9gknd 9615 15 the the DT cord-010119-t1x9gknd 9615 16 risk risk NN cord-010119-t1x9gknd 9615 17 of of IN cord-010119-t1x9gknd 9615 18 travel travel NN cord-010119-t1x9gknd 9615 19 and and CC cord-010119-t1x9gknd 9615 20 sexually sexually RB cord-010119-t1x9gknd 9615 21 transmitted transmit VBN cord-010119-t1x9gknd 9615 22 Zika Zika NNP cord-010119-t1x9gknd 9615 23 infections infection NNS cord-010119-t1x9gknd 9615 24 , , , cord-010119-t1x9gknd 9615 25 the the DT cord-010119-t1x9gknd 9615 26 Food Food NNP cord-010119-t1x9gknd 9615 27 and and CC cord-010119-t1x9gknd 9615 28 Drug Drug NNP cord-010119-t1x9gknd 9615 29 Administration Administration NNP cord-010119-t1x9gknd 9615 30 issued issue VBD cord-010119-t1x9gknd 9615 31 a a DT cord-010119-t1x9gknd 9615 32 guidance guidance NN cord-010119-t1x9gknd 9615 33 document document NN cord-010119-t1x9gknd 9615 34 on on IN cord-010119-t1x9gknd 9615 35 February February NNP cord-010119-t1x9gknd 9615 36 16 16 CD cord-010119-t1x9gknd 9615 37 , , , cord-010119-t1x9gknd 9615 38 2016 2016 CD cord-010119-t1x9gknd 9615 39 recommending recommend VBG cord-010119-t1x9gknd 9615 40 that that IN cord-010119-t1x9gknd 9615 41 blood blood NN cord-010119-t1x9gknd 9615 42 centers center NNS cord-010119-t1x9gknd 9615 43 in in IN cord-010119-t1x9gknd 9615 44 Puerto Puerto NNP cord-010119-t1x9gknd 9615 45 Rico Rico NNP cord-010119-t1x9gknd 9615 46 cease cease VBP cord-010119-t1x9gknd 9615 47 distribution distribution NN cord-010119-t1x9gknd 9615 48 of of IN cord-010119-t1x9gknd 9615 49 locally locally RB cord-010119-t1x9gknd 9615 50 collected collect VBN cord-010119-t1x9gknd 9615 51 blood blood NN cord-010119-t1x9gknd 9615 52 products product NNS cord-010119-t1x9gknd 9615 53 unless unless IN cord-010119-t1x9gknd 9615 54 donors donor NNS cord-010119-t1x9gknd 9615 55 are be VBP cord-010119-t1x9gknd 9615 56 tested test VBN cord-010119-t1x9gknd 9615 57 or or CC cord-010119-t1x9gknd 9615 58 products product NNS cord-010119-t1x9gknd 9615 59 are be VBP cord-010119-t1x9gknd 9615 60 pathogen pathogen NN cord-010119-t1x9gknd 9615 61 reduced reduce VBN cord-010119-t1x9gknd 9615 62 by by IN cord-010119-t1x9gknd 9615 63 March March NNP cord-010119-t1x9gknd 9615 64 1 1 CD cord-010119-t1x9gknd 9615 65 , , , cord-010119-t1x9gknd 9615 66 2016 2016 CD cord-010119-t1x9gknd 9615 67 . . . cord-010119-t1x9gknd 9616 1 With with IN cord-010119-t1x9gknd 9616 2 the the DT cord-010119-t1x9gknd 9616 3 high high JJ cord-010119-t1x9gknd 9616 4 incidence incidence NN cord-010119-t1x9gknd 9616 5 of of IN cord-010119-t1x9gknd 9616 6 Zika Zika NNP cord-010119-t1x9gknd 9616 7 virus virus NN cord-010119-t1x9gknd 9616 8 ( ( -LRB- cord-010119-t1x9gknd 9616 9 ZIKV ZIKV NNP cord-010119-t1x9gknd 9616 10 ) ) -RRB- cord-010119-t1x9gknd 9616 11 in in IN cord-010119-t1x9gknd 9616 12 Puerto Puerto NNP cord-010119-t1x9gknd 9616 13 Rico Rico NNP cord-010119-t1x9gknd 9616 14 and and CC cord-010119-t1x9gknd 9616 15 uncertainty uncertainty NN cord-010119-t1x9gknd 9616 16 of of IN cord-010119-t1x9gknd 9616 17 the the DT cord-010119-t1x9gknd 9616 18 impact impact NN cord-010119-t1x9gknd 9616 19 to to IN cord-010119-t1x9gknd 9616 20 the the DT cord-010119-t1x9gknd 9616 21 continental continental JJ cord-010119-t1x9gknd 9616 22 U.S. U.S. NNP cord-010119-t1x9gknd 9616 23 blood blood NN cord-010119-t1x9gknd 9616 24 supply supply NN cord-010119-t1x9gknd 9616 25 , , , cord-010119-t1x9gknd 9616 26 there there EX cord-010119-t1x9gknd 9616 27 was be VBD cord-010119-t1x9gknd 9616 28 intense intense JJ cord-010119-t1x9gknd 9616 29 pressure pressure NN cord-010119-t1x9gknd 9616 30 to to TO cord-010119-t1x9gknd 9616 31 implement implement VB cord-010119-t1x9gknd 9616 32 a a DT cord-010119-t1x9gknd 9616 33 donor donor NN cord-010119-t1x9gknd 9616 34 screening screening NN cord-010119-t1x9gknd 9616 35 test test NN cord-010119-t1x9gknd 9616 36 for for IN cord-010119-t1x9gknd 9616 37 ZIKV ZIKV NNP cord-010119-t1x9gknd 9616 38 . . . cord-010119-t1x9gknd 9617 1 The the DT cord-010119-t1x9gknd 9617 2 project project NN cord-010119-t1x9gknd 9617 3 was be VBD cord-010119-t1x9gknd 9617 4 initiated initiate VBN cord-010119-t1x9gknd 9617 5 on on IN cord-010119-t1x9gknd 9617 6 February February NNP cord-010119-t1x9gknd 9617 7 16 16 CD cord-010119-t1x9gknd 9617 8 , , , cord-010119-t1x9gknd 9617 9 2016 2016 CD cord-010119-t1x9gknd 9617 10 and and CC cord-010119-t1x9gknd 9617 11 included include VBD cord-010119-t1x9gknd 9617 12 clinical clinical JJ cord-010119-t1x9gknd 9617 13 trial trial NN cord-010119-t1x9gknd 9617 14 requirements requirement NNS cord-010119-t1x9gknd 9617 15 , , , cord-010119-t1x9gknd 9617 16 client client NN cord-010119-t1x9gknd 9617 17 onboarding onboarding NN cord-010119-t1x9gknd 9617 18 and and CC cord-010119-t1x9gknd 9617 19 laboratory laboratory NN cord-010119-t1x9gknd 9617 20 operations operation NNS cord-010119-t1x9gknd 9617 21 . . . cord-010119-t1x9gknd 9618 1 Stakeholders stakeholder NNS cord-010119-t1x9gknd 9618 2 consisted consist VBD cord-010119-t1x9gknd 9618 3 of of IN cord-010119-t1x9gknd 9618 4 clients client NNS cord-010119-t1x9gknd 9618 5 , , , cord-010119-t1x9gknd 9618 6 the the DT cord-010119-t1x9gknd 9618 7 manufacturer manufacturer NN cord-010119-t1x9gknd 9618 8 , , , cord-010119-t1x9gknd 9618 9 Institutional Institutional NNP cord-010119-t1x9gknd 9618 10 Review Review NNP cord-010119-t1x9gknd 9618 11 Boards Boards NNP cord-010119-t1x9gknd 9618 12 ( ( -LRB- cord-010119-t1x9gknd 9618 13 IRB IRB NNP cord-010119-t1x9gknd 9618 14 ) ) -RRB- cord-010119-t1x9gknd 9618 15 , , , cord-010119-t1x9gknd 9618 16 Informational Informational NNP cord-010119-t1x9gknd 9618 17 Technology Technology NNP cord-010119-t1x9gknd 9618 18 ( ( -LRB- cord-010119-t1x9gknd 9618 19 client client NN cord-010119-t1x9gknd 9618 20 and and CC cord-010119-t1x9gknd 9618 21 lab lab NN cord-010119-t1x9gknd 9618 22 based base VBN cord-010119-t1x9gknd 9618 23 ) ) -RRB- cord-010119-t1x9gknd 9618 24 , , , cord-010119-t1x9gknd 9618 25 the the DT cord-010119-t1x9gknd 9618 26 Food Food NNP cord-010119-t1x9gknd 9618 27 and and CC cord-010119-t1x9gknd 9618 28 Drug Drug NNP cord-010119-t1x9gknd 9618 29 Administration Administration NNP cord-010119-t1x9gknd 9618 30 ( ( -LRB- cord-010119-t1x9gknd 9618 31 FDA FDA NNP cord-010119-t1x9gknd 9618 32 ) ) -RRB- cord-010119-t1x9gknd 9618 33 , , , cord-010119-t1x9gknd 9618 34 the the DT cord-010119-t1x9gknd 9618 35 Centers Centers NNPS cord-010119-t1x9gknd 9618 36 for for IN cord-010119-t1x9gknd 9618 37 Disease Disease NNP cord-010119-t1x9gknd 9618 38 Control Control NNP cord-010119-t1x9gknd 9618 39 CDC CDC NNP cord-010119-t1x9gknd 9618 40 , , , cord-010119-t1x9gknd 9618 41 and and CC cord-010119-t1x9gknd 9618 42 the the DT cord-010119-t1x9gknd 9618 43 Florida Florida NNP cord-010119-t1x9gknd 9618 44 Department Department NNP cord-010119-t1x9gknd 9618 45 of of IN cord-010119-t1x9gknd 9618 46 Health Health NNP cord-010119-t1x9gknd 9618 47 . . . cord-010119-t1x9gknd 9619 1 Clinical clinical JJ cord-010119-t1x9gknd 9619 2 trial trial NN cord-010119-t1x9gknd 9619 3 requirements requirement NNS cord-010119-t1x9gknd 9619 4 included include VBD cord-010119-t1x9gknd 9619 5 development development NN cord-010119-t1x9gknd 9619 6 of of IN cord-010119-t1x9gknd 9619 7 instrument instrument NN cord-010119-t1x9gknd 9619 8 and and CC cord-010119-t1x9gknd 9619 9 assay assay NN cord-010119-t1x9gknd 9619 10 validations validation NNS cord-010119-t1x9gknd 9619 11 , , , cord-010119-t1x9gknd 9619 12 SOP sop NN cord-010119-t1x9gknd 9619 13 creation creation NN cord-010119-t1x9gknd 9619 14 , , , cord-010119-t1x9gknd 9619 15 result result NN cord-010119-t1x9gknd 9619 16 reporting reporting NN cord-010119-t1x9gknd 9619 17 , , , cord-010119-t1x9gknd 9619 18 assay assay NN cord-010119-t1x9gknd 9619 19 and and CC cord-010119-t1x9gknd 9619 20 clinical clinical JJ cord-010119-t1x9gknd 9619 21 trial trial NN cord-010119-t1x9gknd 9619 22 training training NN cord-010119-t1x9gknd 9619 23 , , , cord-010119-t1x9gknd 9619 24 deviation deviation NN cord-010119-t1x9gknd 9619 25 management management NN cord-010119-t1x9gknd 9619 26 , , , cord-010119-t1x9gknd 9619 27 donor donor NN cord-010119-t1x9gknd 9619 28 notification notification NN cord-010119-t1x9gknd 9619 29 , , , cord-010119-t1x9gknd 9619 30 and and CC cord-010119-t1x9gknd 9619 31 follow follow VB cord-010119-t1x9gknd 9619 32 up up RP cord-010119-t1x9gknd 9619 33 sample sample NN cord-010119-t1x9gknd 9619 34 handling handling NN cord-010119-t1x9gknd 9619 35 . . . cord-010119-t1x9gknd 9620 1 Client client NN cord-010119-t1x9gknd 9620 2 onboarding onboarding NN cord-010119-t1x9gknd 9620 3 began begin VBD cord-010119-t1x9gknd 9620 4 with with IN cord-010119-t1x9gknd 9620 5 confidentiality confidentiality NN cord-010119-t1x9gknd 9620 6 agreements agreement NNS cord-010119-t1x9gknd 9620 7 between between IN cord-010119-t1x9gknd 9620 8 the the DT cord-010119-t1x9gknd 9620 9 client client NN cord-010119-t1x9gknd 9620 10 and and CC cord-010119-t1x9gknd 9620 11 the the DT cord-010119-t1x9gknd 9620 12 sponsor sponsor NN cord-010119-t1x9gknd 9620 13 . . . cord-010119-t1x9gknd 9621 1 A a DT cord-010119-t1x9gknd 9621 2 Zika Zika NNP cord-010119-t1x9gknd 9621 3 based base VBN cord-010119-t1x9gknd 9621 4 webinar webinar NN cord-010119-t1x9gknd 9621 5 was be VBD cord-010119-t1x9gknd 9621 6 created create VBN cord-010119-t1x9gknd 9621 7 to to TO cord-010119-t1x9gknd 9621 8 provide provide VB cord-010119-t1x9gknd 9621 9 an an DT cord-010119-t1x9gknd 9621 10 overview overview NN cord-010119-t1x9gknd 9621 11 of of IN cord-010119-t1x9gknd 9621 12 the the DT cord-010119-t1x9gknd 9621 13 sponsor sponsor NN cord-010119-t1x9gknd 9621 14 protocol protocol NN cord-010119-t1x9gknd 9621 15 , , , cord-010119-t1x9gknd 9621 16 lab lab NN cord-010119-t1x9gknd 9621 17 test test NN cord-010119-t1x9gknd 9621 18 system system NN cord-010119-t1x9gknd 9621 19 and and CC cord-010119-t1x9gknd 9621 20 client client NN cord-010119-t1x9gknd 9621 21 responsibilities responsibility NNS cord-010119-t1x9gknd 9621 22 . . . cord-010119-t1x9gknd 9622 1 The the DT cord-010119-t1x9gknd 9622 2 complexity complexity NN cord-010119-t1x9gknd 9622 3 of of IN cord-010119-t1x9gknd 9622 4 the the DT cord-010119-t1x9gknd 9622 5 project project NN cord-010119-t1x9gknd 9622 6 increased increase VBD cord-010119-t1x9gknd 9622 7 when when WRB cord-010119-t1x9gknd 9622 8 mosquito mosquito NN cord-010119-t1x9gknd 9622 9 borne bear VBN cord-010119-t1x9gknd 9622 10 Zika Zika NNP cord-010119-t1x9gknd 9622 11 transmission transmission NN cord-010119-t1x9gknd 9622 12 was be VBD cord-010119-t1x9gknd 9622 13 identified identify VBN cord-010119-t1x9gknd 9622 14 in in IN cord-010119-t1x9gknd 9622 15 two two CD cord-010119-t1x9gknd 9622 16 counties county NNS cord-010119-t1x9gknd 9622 17 in in IN cord-010119-t1x9gknd 9622 18 Florida Florida NNP cord-010119-t1x9gknd 9622 19 . . . cord-010119-t1x9gknd 9623 1 This this DT cord-010119-t1x9gknd 9623 2 required require VBN cord-010119-t1x9gknd 9623 3 ZIKV ZIKV NNP cord-010119-t1x9gknd 9623 4 testing testing NN cord-010119-t1x9gknd 9623 5 to to TO cord-010119-t1x9gknd 9623 6 be be VB cord-010119-t1x9gknd 9623 7 performed perform VBN cord-010119-t1x9gknd 9623 8 on on IN cord-010119-t1x9gknd 9623 9 collections collection NNS cord-010119-t1x9gknd 9623 10 in in IN cord-010119-t1x9gknd 9623 11 both both CC cord-010119-t1x9gknd 9623 12 Florida Florida NNP cord-010119-t1x9gknd 9623 13 and and CC cord-010119-t1x9gknd 9623 14 Puerto Puerto NNP cord-010119-t1x9gknd 9623 15 Rico Rico NNP cord-010119-t1x9gknd 9623 16 . . . cord-010119-t1x9gknd 9624 1 The the DT cord-010119-t1x9gknd 9624 2 ZIKV ZIKV NNP cord-010119-t1x9gknd 9624 3 - - HYPH cord-010119-t1x9gknd 9624 4 NAT NAT NNP cord-010119-t1x9gknd 9624 5 is be VBZ cord-010119-t1x9gknd 9624 6 performed perform VBN cord-010119-t1x9gknd 9624 7 in in IN cord-010119-t1x9gknd 9624 8 singlet singlet NN cord-010119-t1x9gknd 9624 9 , , , cord-010119-t1x9gknd 9624 10 unlike unlike IN cord-010119-t1x9gknd 9624 11 the the DT cord-010119-t1x9gknd 9624 12 MPX MPX NNP cord-010119-t1x9gknd 9624 13 and and CC cord-010119-t1x9gknd 9624 14 WNV WNV NNP cord-010119-t1x9gknd 9624 15 assays assay NNS cord-010119-t1x9gknd 9624 16 which which WDT cord-010119-t1x9gknd 9624 17 are be VBP cord-010119-t1x9gknd 9624 18 run run VBN cord-010119-t1x9gknd 9624 19 in in IN cord-010119-t1x9gknd 9624 20 minipools minipool NNS cord-010119-t1x9gknd 9624 21 . . . cord-010119-t1x9gknd 9625 1 This this DT cord-010119-t1x9gknd 9625 2 had have VBD cord-010119-t1x9gknd 9625 3 a a DT cord-010119-t1x9gknd 9625 4 significant significant JJ cord-010119-t1x9gknd 9625 5 impact impact NN cord-010119-t1x9gknd 9625 6 on on IN cord-010119-t1x9gknd 9625 7 instrument instrument NN cord-010119-t1x9gknd 9625 8 capacity capacity NN cord-010119-t1x9gknd 9625 9 . . . cord-010119-t1x9gknd 9626 1 Despite despite IN cord-010119-t1x9gknd 9626 2 these these DT cord-010119-t1x9gknd 9626 3 obstacles obstacle NNS cord-010119-t1x9gknd 9626 4 and and CC cord-010119-t1x9gknd 9626 5 the the DT cord-010119-t1x9gknd 9626 6 changing change VBG cord-010119-t1x9gknd 9626 7 regulatory regulatory JJ cord-010119-t1x9gknd 9626 8 requirements requirement NNS cord-010119-t1x9gknd 9626 9 , , , cord-010119-t1x9gknd 9626 10 the the DT cord-010119-t1x9gknd 9626 11 ZIKV ZIKV NNP cord-010119-t1x9gknd 9626 12 screening screening NN cord-010119-t1x9gknd 9626 13 test test NN cord-010119-t1x9gknd 9626 14 was be VBD cord-010119-t1x9gknd 9626 15 implemented implement VBN cord-010119-t1x9gknd 9626 16 within within IN cord-010119-t1x9gknd 9626 17 six six CD cord-010119-t1x9gknd 9626 18 weeks week NNS cord-010119-t1x9gknd 9626 19 . . . cord-010119-t1x9gknd 9627 1 Study Study NNP cord-010119-t1x9gknd 9627 2 Design Design NNP cord-010119-t1x9gknd 9627 3 / / SYM cord-010119-t1x9gknd 9627 4 Method method NN cord-010119-t1x9gknd 9627 5 : : : cord-010119-t1x9gknd 9628 1 One one CD cord-010119-t1x9gknd 9628 2 metric metric NN cord-010119-t1x9gknd 9628 3 used use VBN cord-010119-t1x9gknd 9628 4 to to TO cord-010119-t1x9gknd 9628 5 measure measure VB cord-010119-t1x9gknd 9628 6 client client NN cord-010119-t1x9gknd 9628 7 service service NN cord-010119-t1x9gknd 9628 8 levels level NNS cord-010119-t1x9gknd 9628 9 is be VBZ cord-010119-t1x9gknd 9628 10 our -PRON- PRP$ cord-010119-t1x9gknd 9628 11 ability ability NN cord-010119-t1x9gknd 9628 12 to to TO cord-010119-t1x9gknd 9628 13 meet meet VB cord-010119-t1x9gknd 9628 14 established establish VBN cord-010119-t1x9gknd 9628 15 upload upload NN cord-010119-t1x9gknd 9628 16 time time NN cord-010119-t1x9gknd 9628 17 goals goal NNS cord-010119-t1x9gknd 9628 18 for for IN cord-010119-t1x9gknd 9628 19 individual individual JJ cord-010119-t1x9gknd 9628 20 clients client NNS cord-010119-t1x9gknd 9628 21 . . . cord-010119-t1x9gknd 9629 1 The the DT cord-010119-t1x9gknd 9629 2 percentage percentage NN cord-010119-t1x9gknd 9629 3 of of IN cord-010119-t1x9gknd 9629 4 samples sample NNS cord-010119-t1x9gknd 9629 5 released release VBN cord-010119-t1x9gknd 9629 6 on on IN cord-010119-t1x9gknd 9629 7 time time NN cord-010119-t1x9gknd 9629 8 is be VBZ cord-010119-t1x9gknd 9629 9 evaluated evaluate VBN cord-010119-t1x9gknd 9629 10 daily daily RB cord-010119-t1x9gknd 9629 11 with with IN cord-010119-t1x9gknd 9629 12 a a DT cord-010119-t1x9gknd 9629 13 running run VBG cord-010119-t1x9gknd 9629 14 monthly monthly JJ cord-010119-t1x9gknd 9629 15 total total NN cord-010119-t1x9gknd 9629 16 . . . cord-010119-t1x9gknd 9630 1 Our -PRON- PRP$ cord-010119-t1x9gknd 9630 2 upload upload NN cord-010119-t1x9gknd 9630 3 time time NN cord-010119-t1x9gknd 9630 4 goals goal NNS cord-010119-t1x9gknd 9630 5 were be VBD cord-010119-t1x9gknd 9630 6 negatively negatively RB cord-010119-t1x9gknd 9630 7 impacted impact VBN cord-010119-t1x9gknd 9630 8 from from IN cord-010119-t1x9gknd 9630 9 July July NNP cord-010119-t1x9gknd 9630 10 through through IN cord-010119-t1x9gknd 9630 11 September September NNP cord-010119-t1x9gknd 9630 12 due due IN cord-010119-t1x9gknd 9630 13 to to IN cord-010119-t1x9gknd 9630 14 the the DT cord-010119-t1x9gknd 9630 15 unexpected unexpected JJ cord-010119-t1x9gknd 9630 16 increase increase NN cord-010119-t1x9gknd 9630 17 in in IN cord-010119-t1x9gknd 9630 18 ZIKV ZIKV NNP cord-010119-t1x9gknd 9630 19 testing testing NN cord-010119-t1x9gknd 9630 20 , , , cord-010119-t1x9gknd 9630 21 the the DT cord-010119-t1x9gknd 9630 22 requirement requirement NN cord-010119-t1x9gknd 9630 23 to to TO cord-010119-t1x9gknd 9630 24 perform perform VB cord-010119-t1x9gknd 9630 25 testing testing NN cord-010119-t1x9gknd 9630 26 in in IN cord-010119-t1x9gknd 9630 27 singlets singlet NNS cord-010119-t1x9gknd 9630 28 and and CC cord-010119-t1x9gknd 9630 29 the the DT cord-010119-t1x9gknd 9630 30 resulting result VBG cord-010119-t1x9gknd 9630 31 instrument instrument NN cord-010119-t1x9gknd 9630 32 capacity capacity NN cord-010119-t1x9gknd 9630 33 issues issue NNS cord-010119-t1x9gknd 9630 34 . . . cord-010119-t1x9gknd 9631 1 Additional additional JJ cord-010119-t1x9gknd 9631 2 instruments instrument NNS cord-010119-t1x9gknd 9631 3 were be VBD cord-010119-t1x9gknd 9631 4 sourced source VBN cord-010119-t1x9gknd 9631 5 in in IN cord-010119-t1x9gknd 9631 6 October October NNP cord-010119-t1x9gknd 9631 7 and and CC cord-010119-t1x9gknd 9631 8 operations operation NNS cord-010119-t1x9gknd 9631 9 stabilized stabilize VBD cord-010119-t1x9gknd 9631 10 . . . cord-010119-t1x9gknd 9632 1 Conclusion conclusion NN cord-010119-t1x9gknd 9632 2 : : : cord-010119-t1x9gknd 9632 3 On on IN cord-010119-t1x9gknd 9632 4 February February NNP cord-010119-t1x9gknd 9632 5 16 16 CD cord-010119-t1x9gknd 9632 6 , , , cord-010119-t1x9gknd 9632 7 2016 2016 CD cord-010119-t1x9gknd 9632 8 , , , cord-010119-t1x9gknd 9632 9 the the DT cord-010119-t1x9gknd 9632 10 project project NN cord-010119-t1x9gknd 9632 11 to to TO cord-010119-t1x9gknd 9632 12 implement implement VB cord-010119-t1x9gknd 9632 13 a a DT cord-010119-t1x9gknd 9632 14 ZIKV ZIKV NNP cord-010119-t1x9gknd 9632 15 IND IND NNP cord-010119-t1x9gknd 9632 16 test test NN cord-010119-t1x9gknd 9632 17 was be VBD cord-010119-t1x9gknd 9632 18 initiated initiate VBN cord-010119-t1x9gknd 9632 19 . . . cord-010119-t1x9gknd 9633 1 Six six CD cord-010119-t1x9gknd 9633 2 weeks week NNS cord-010119-t1x9gknd 9633 3 later later RB cord-010119-t1x9gknd 9633 4 , , , cord-010119-t1x9gknd 9633 5 testing testing NN cord-010119-t1x9gknd 9633 6 was be VBD cord-010119-t1x9gknd 9633 7 performed perform VBN cord-010119-t1x9gknd 9633 8 on on IN cord-010119-t1x9gknd 9633 9 the the DT cord-010119-t1x9gknd 9633 10 first first JJ cord-010119-t1x9gknd 9633 11 batch batch NN cord-010119-t1x9gknd 9633 12 of of IN cord-010119-t1x9gknd 9633 13 samples sample NNS cord-010119-t1x9gknd 9633 14 . . . cord-010119-t1x9gknd 9634 1 Despite despite IN cord-010119-t1x9gknd 9634 2 the the DT cord-010119-t1x9gknd 9634 3 changing change VBG cord-010119-t1x9gknd 9634 4 regulatory regulatory JJ cord-010119-t1x9gknd 9634 5 requirements requirement NNS cord-010119-t1x9gknd 9634 6 over over IN cord-010119-t1x9gknd 9634 7 time time NN cord-010119-t1x9gknd 9634 8 , , , cord-010119-t1x9gknd 9634 9 the the DT cord-010119-t1x9gknd 9634 10 implementation implementation NN cord-010119-t1x9gknd 9634 11 was be VBD cord-010119-t1x9gknd 9634 12 extremely extremely RB cord-010119-t1x9gknd 9634 13 successful successful JJ cord-010119-t1x9gknd 9634 14 . . . cord-010119-t1x9gknd 9635 1 Initiating initiate VBG cord-010119-t1x9gknd 9635 2 a a DT cord-010119-t1x9gknd 9635 3 new new JJ cord-010119-t1x9gknd 9635 4 IND IND NNP cord-010119-t1x9gknd 9635 5 testing testing NN cord-010119-t1x9gknd 9635 6 within within IN cord-010119-t1x9gknd 9635 7 6 6 CD cord-010119-t1x9gknd 9635 8 weeks week NNS cord-010119-t1x9gknd 9635 9 is be VBZ cord-010119-t1x9gknd 9635 10 unprecedented unprecedented JJ cord-010119-t1x9gknd 9635 11 and and CC cord-010119-t1x9gknd 9635 12 required require VBN cord-010119-t1x9gknd 9635 13 exceptional exceptional JJ cord-010119-t1x9gknd 9635 14 collaboration collaboration NN cord-010119-t1x9gknd 9635 15 between between IN cord-010119-t1x9gknd 9635 16 all all DT cord-010119-t1x9gknd 9635 17 participants participant NNS cord-010119-t1x9gknd 9635 18 and and CC cord-010119-t1x9gknd 9635 19 stakeholders stakeholder NNS cord-010119-t1x9gknd 9635 20 . . . cord-010119-t1x9gknd 9636 1 Background Background NNP cord-010119-t1x9gknd 9636 2 / / SYM cord-010119-t1x9gknd 9636 3 Case Case NNP cord-010119-t1x9gknd 9636 4 Studies Studies NNPS cord-010119-t1x9gknd 9636 5 : : : cord-010119-t1x9gknd 9636 6 Plasmodium plasmodium NN cord-010119-t1x9gknd 9636 7 falciparum falciparum NN cord-010119-t1x9gknd 9636 8 ( ( -LRB- cord-010119-t1x9gknd 9636 9 Pf Pf NNP cord-010119-t1x9gknd 9636 10 ) ) -RRB- cord-010119-t1x9gknd 9636 11 , , , cord-010119-t1x9gknd 9636 12 an an DT cord-010119-t1x9gknd 9636 13 intraerythrocytic intraerythrocytic JJ cord-010119-t1x9gknd 9636 14 protozoan protozoan NN cord-010119-t1x9gknd 9636 15 parasite parasite NN cord-010119-t1x9gknd 9636 16 , , , cord-010119-t1x9gknd 9636 17 is be VBZ cord-010119-t1x9gknd 9636 18 accountable accountable JJ cord-010119-t1x9gknd 9636 19 for for IN cord-010119-t1x9gknd 9636 20 nearly nearly RB cord-010119-t1x9gknd 9636 21 all all DT cord-010119-t1x9gknd 9636 22 malaria malaria NN cord-010119-t1x9gknd 9636 23 mortality mortality NN cord-010119-t1x9gknd 9636 24 in in IN cord-010119-t1x9gknd 9636 25 Africa Africa NNP cord-010119-t1x9gknd 9636 26 . . . cord-010119-t1x9gknd 9637 1 In in IN cord-010119-t1x9gknd 9637 2 2015 2015 CD cord-010119-t1x9gknd 9637 3 , , , cord-010119-t1x9gknd 9637 4 WHO who WP cord-010119-t1x9gknd 9637 5 reported report VBD cord-010119-t1x9gknd 9637 6 $ $ $ cord-010119-t1x9gknd 9637 7 212 212 CD cord-010119-t1x9gknd 9637 8 million million CD cord-010119-t1x9gknd 9637 9 new new JJ cord-010119-t1x9gknd 9637 10 cases case NNS cord-010119-t1x9gknd 9637 11 worldwide worldwide RB cord-010119-t1x9gknd 9637 12 , , , cord-010119-t1x9gknd 9637 13 resulting result VBG cord-010119-t1x9gknd 9637 14 in in IN cord-010119-t1x9gknd 9637 15 > > $ cord-010119-t1x9gknd 9637 16 400,000 400,000 CD cord-010119-t1x9gknd 9637 17 deaths death NNS cord-010119-t1x9gknd 9637 18 . . . cord-010119-t1x9gknd 9638 1 Malaria malaria NN cord-010119-t1x9gknd 9638 2 prevalence prevalence NN cord-010119-t1x9gknd 9638 3 is be VBZ cord-010119-t1x9gknd 9638 4 highest high JJS cord-010119-t1x9gknd 9638 5 in in IN cord-010119-t1x9gknd 9638 6 sub sub JJ cord-010119-t1x9gknd 9638 7 - - JJ cord-010119-t1x9gknd 9638 8 Saharan Saharan NNP cord-010119-t1x9gknd 9638 9 Africa Africa NNP cord-010119-t1x9gknd 9638 10 , , , cord-010119-t1x9gknd 9638 11 home home NN cord-010119-t1x9gknd 9638 12 to to IN cord-010119-t1x9gknd 9638 13 90 90 CD cord-010119-t1x9gknd 9638 14 % % NN cord-010119-t1x9gknd 9638 15 of of IN cord-010119-t1x9gknd 9638 16 all all DT cord-010119-t1x9gknd 9638 17 infections infection NNS cord-010119-t1x9gknd 9638 18 accounting account VBG cord-010119-t1x9gknd 9638 19 for for IN cord-010119-t1x9gknd 9638 20 92 92 CD cord-010119-t1x9gknd 9638 21 % % NN cord-010119-t1x9gknd 9638 22 of of IN cord-010119-t1x9gknd 9638 23 mortalities mortality NNS cord-010119-t1x9gknd 9638 24 . . . cord-010119-t1x9gknd 9639 1 Both both DT cord-010119-t1x9gknd 9639 2 the the DT cord-010119-t1x9gknd 9639 3 incidence incidence NN cord-010119-t1x9gknd 9639 4 and and CC cord-010119-t1x9gknd 9639 5 prevalence prevalence NN cord-010119-t1x9gknd 9639 6 of of IN cord-010119-t1x9gknd 9639 7 malaria malaria NN cord-010119-t1x9gknd 9639 8 in in IN cord-010119-t1x9gknd 9639 9 Africa Africa NNP cord-010119-t1x9gknd 9639 10 significantly significantly RB cord-010119-t1x9gknd 9639 11 increase increase VB cord-010119-t1x9gknd 9639 12 the the DT cord-010119-t1x9gknd 9639 13 potential potential NN cord-010119-t1x9gknd 9639 14 for for IN cord-010119-t1x9gknd 9639 15 transfusion transfusion NN cord-010119-t1x9gknd 9639 16 - - HYPH cord-010119-t1x9gknd 9639 17 transmission transmission NN cord-010119-t1x9gknd 9639 18 ( ( -LRB- cord-010119-t1x9gknd 9639 19 TT TT NNP cord-010119-t1x9gknd 9639 20 ) ) -RRB- cord-010119-t1x9gknd 9639 21 , , , cord-010119-t1x9gknd 9639 22 with with IN cord-010119-t1x9gknd 9639 23 little little JJ cord-010119-t1x9gknd 9639 24 to to IN cord-010119-t1x9gknd 9639 25 no no DT cord-010119-t1x9gknd 9639 26 screening screening NN cord-010119-t1x9gknd 9639 27 of of IN cord-010119-t1x9gknd 9639 28 products product NNS cord-010119-t1x9gknd 9639 29 in in IN cord-010119-t1x9gknd 9639 30 developing develop VBG cord-010119-t1x9gknd 9639 31 countries country NNS cord-010119-t1x9gknd 9639 32 . . . cord-010119-t1x9gknd 9640 1 The the DT cord-010119-t1x9gknd 9640 2 objective objective NN cord-010119-t1x9gknd 9640 3 of of IN cord-010119-t1x9gknd 9640 4 this this DT cord-010119-t1x9gknd 9640 5 study study NN cord-010119-t1x9gknd 9640 6 was be VBD cord-010119-t1x9gknd 9640 7 to to TO cord-010119-t1x9gknd 9640 8 evaluate evaluate VB cord-010119-t1x9gknd 9640 9 the the DT cord-010119-t1x9gknd 9640 10 inactivation inactivation NN cord-010119-t1x9gknd 9640 11 of of IN cord-010119-t1x9gknd 9640 12 Pf Pf NNP cord-010119-t1x9gknd 9640 13 in in IN cord-010119-t1x9gknd 9640 14 Whole Whole NNP cord-010119-t1x9gknd 9640 15 Blood Blood NNP cord-010119-t1x9gknd 9640 16 ( ( -LRB- cord-010119-t1x9gknd 9640 17 WB WB NNP cord-010119-t1x9gknd 9640 18 ) ) -RRB- cord-010119-t1x9gknd 9640 19 using use VBG cord-010119-t1x9gknd 9640 20 a a DT cord-010119-t1x9gknd 9640 21 system system NN cord-010119-t1x9gknd 9640 22 specifically specifically RB cord-010119-t1x9gknd 9640 23 developed develop VBN cord-010119-t1x9gknd 9640 24 for for IN cord-010119-t1x9gknd 9640 25 the the DT cord-010119-t1x9gknd 9640 26 realities reality NNS cord-010119-t1x9gknd 9640 27 of of IN cord-010119-t1x9gknd 9640 28 the the DT cord-010119-t1x9gknd 9640 29 developing develop VBG cord-010119-t1x9gknd 9640 30 world world NN cord-010119-t1x9gknd 9640 31 and and CC cord-010119-t1x9gknd 9640 32 in in IN cord-010119-t1x9gknd 9640 33 support support NN cord-010119-t1x9gknd 9640 34 of of IN cord-010119-t1x9gknd 9640 35 the the DT cord-010119-t1x9gknd 9640 36 Swiss Swiss NNP cord-010119-t1x9gknd 9640 37 Red Red NNP cord-010119-t1x9gknd 9640 38 Cross Cross NNP cord-010119-t1x9gknd 9640 39 Humanitarian Humanitarian NNP cord-010119-t1x9gknd 9640 40 Foundation Foundation NNP cord-010119-t1x9gknd 9640 41 for for IN cord-010119-t1x9gknd 9640 42 Whole Whole NNP cord-010119-t1x9gknd 9640 43 Blood Blood NNP cord-010119-t1x9gknd 9640 44 Pathogen Pathogen NNP cord-010119-t1x9gknd 9640 45 Inactivation Inactivation NNP cord-010119-t1x9gknd 9640 46 for for IN cord-010119-t1x9gknd 9640 47 Africa Africa NNP cord-010119-t1x9gknd 9640 48 . . . cord-010119-t1x9gknd 9641 1 The the DT cord-010119-t1x9gknd 9641 2 inability inability NN cord-010119-t1x9gknd 9641 3 to to TO cord-010119-t1x9gknd 9641 4 consistently consistently RB cord-010119-t1x9gknd 9641 5 supply supply VB cord-010119-t1x9gknd 9641 6 blood blood NN cord-010119-t1x9gknd 9641 7 components component NNS cord-010119-t1x9gknd 9641 8 leads lead VBZ cord-010119-t1x9gknd 9641 9 to to IN cord-010119-t1x9gknd 9641 10 routine routine JJ cord-010119-t1x9gknd 9641 11 WB WB NNP cord-010119-t1x9gknd 9641 12 transfusion transfusion NN cord-010119-t1x9gknd 9641 13 , , , cord-010119-t1x9gknd 9641 14 and and CC cord-010119-t1x9gknd 9641 15 as as IN cord-010119-t1x9gknd 9641 16 transfusion transfusion NN cord-010119-t1x9gknd 9641 17 - - HYPH cord-010119-t1x9gknd 9641 18 transmitted transmit VBN cord-010119-t1x9gknd 9641 19 diseases disease NNS cord-010119-t1x9gknd 9641 20 are be VBP cord-010119-t1x9gknd 9641 21 prevalent prevalent JJ cord-010119-t1x9gknd 9641 22 in in IN cord-010119-t1x9gknd 9641 23 the the DT cord-010119-t1x9gknd 9641 24 developing develop VBG cord-010119-t1x9gknd 9641 25 world world NN cord-010119-t1x9gknd 9641 26 , , , cord-010119-t1x9gknd 9641 27 the the DT cord-010119-t1x9gknd 9641 28 establishment establishment NN cord-010119-t1x9gknd 9641 29 of of IN cord-010119-t1x9gknd 9641 30 a a DT cord-010119-t1x9gknd 9641 31 robust robust JJ cord-010119-t1x9gknd 9641 32 WB WB NNP cord-010119-t1x9gknd 9641 33 pathogen pathogen NN cord-010119-t1x9gknd 9641 34 inactivation inactivation NN cord-010119-t1x9gknd 9641 35 system system NN cord-010119-t1x9gknd 9641 36 is be VBZ cord-010119-t1x9gknd 9641 37 desirable desirable JJ cord-010119-t1x9gknd 9641 38 . . . cord-010119-t1x9gknd 9642 1 The the DT cord-010119-t1x9gknd 9642 2 approach approach NN cord-010119-t1x9gknd 9642 3 uses use VBZ cord-010119-t1x9gknd 9642 4 the the DT cord-010119-t1x9gknd 9642 5 small small JJ cord-010119-t1x9gknd 9642 6 molecule molecule NN cord-010119-t1x9gknd 9642 7 amustaline amustaline NN cord-010119-t1x9gknd 9642 8 to to TO cord-010119-t1x9gknd 9642 9 form form VB cord-010119-t1x9gknd 9642 10 covalent covalent JJ cord-010119-t1x9gknd 9642 11 adducts adduct NNS cord-010119-t1x9gknd 9642 12 and and CC cord-010119-t1x9gknd 9642 13 crosslinks crosslink NNS cord-010119-t1x9gknd 9642 14 within within IN cord-010119-t1x9gknd 9642 15 nucleic nucleic JJ cord-010119-t1x9gknd 9642 16 acids acid NNS cord-010119-t1x9gknd 9642 17 of of IN cord-010119-t1x9gknd 9642 18 leukocytes leukocyte NNS cord-010119-t1x9gknd 9642 19 and and CC cord-010119-t1x9gknd 9642 20 contaminating contaminate VBG cord-010119-t1x9gknd 9642 21 pathogens pathogen NNS cord-010119-t1x9gknd 9642 22 to to TO cord-010119-t1x9gknd 9642 23 prevent prevent VB cord-010119-t1x9gknd 9642 24 replication replication NN cord-010119-t1x9gknd 9642 25 . . . cord-010119-t1x9gknd 9643 1 The the DT cord-010119-t1x9gknd 9643 2 process process NN cord-010119-t1x9gknd 9643 3 includes include VBZ cord-010119-t1x9gknd 9643 4 addition addition NN cord-010119-t1x9gknd 9643 5 of of IN cord-010119-t1x9gknd 9643 6 0.2 0.2 CD cord-010119-t1x9gknd 9643 7 mM mm CD cord-010119-t1x9gknd 9643 8 amustaline amustaline NN cord-010119-t1x9gknd 9643 9 and and CC cord-010119-t1x9gknd 9643 10 2 2 CD cord-010119-t1x9gknd 9643 11 mM mm CD cord-010119-t1x9gknd 9643 12 glutathione glutathione NN cord-010119-t1x9gknd 9643 13 ( ( -LRB- cord-010119-t1x9gknd 9643 14 GSH GSH NNP cord-010119-t1x9gknd 9643 15 ) ) -RRB- cord-010119-t1x9gknd 9643 16 and and CC cord-010119-t1x9gknd 9643 17 a a DT cord-010119-t1x9gknd 9643 18 24h 24h NNS cord-010119-t1x9gknd 9643 19 at at IN cord-010119-t1x9gknd 9643 20 room room NN cord-010119-t1x9gknd 9643 21 temperature temperature NN cord-010119-t1x9gknd 9643 22 ( ( -LRB- cord-010119-t1x9gknd 9643 23 RT rt NN cord-010119-t1x9gknd 9643 24 ) ) -RRB- cord-010119-t1x9gknd 9643 25 incubation incubation NN cord-010119-t1x9gknd 9643 26 after after IN cord-010119-t1x9gknd 9643 27 which which WDT cord-010119-t1x9gknd 9643 28 the the DT cord-010119-t1x9gknd 9643 29 treated treat VBN cord-010119-t1x9gknd 9643 30 WB WB NNP cord-010119-t1x9gknd 9643 31 unit unit NN cord-010119-t1x9gknd 9643 32 is be VBZ cord-010119-t1x9gknd 9643 33 suitable suitable JJ cord-010119-t1x9gknd 9643 34 for for IN cord-010119-t1x9gknd 9643 35 storage storage NN cord-010119-t1x9gknd 9643 36 up up IN cord-010119-t1x9gknd 9643 37 to to TO cord-010119-t1x9gknd 9643 38 7 7 CD cord-010119-t1x9gknd 9643 39 days day NNS cord-010119-t1x9gknd 9643 40 at at IN cord-010119-t1x9gknd 9643 41 RT RT NNP cord-010119-t1x9gknd 9643 42 . . . cord-010119-t1x9gknd 9644 1 Study Study NNP cord-010119-t1x9gknd 9644 2 Design Design NNP cord-010119-t1x9gknd 9644 3 / / SYM cord-010119-t1x9gknd 9644 4 Method method NN cord-010119-t1x9gknd 9644 5 : : : cord-010119-t1x9gknd 9644 6 For for IN cord-010119-t1x9gknd 9644 7 each each DT cord-010119-t1x9gknd 9644 8 experiment experiment NN cord-010119-t1x9gknd 9644 9 , , , cord-010119-t1x9gknd 9644 10 a a DT cord-010119-t1x9gknd 9644 11 WB WB NNP cord-010119-t1x9gknd 9644 12 unit unit NN cord-010119-t1x9gknd 9644 13 was be VBD cord-010119-t1x9gknd 9644 14 spiked spike VBN cord-010119-t1x9gknd 9644 15 with with IN cord-010119-t1x9gknd 9644 16 ring ring NN cord-010119-t1x9gknd 9644 17 - - HYPH cord-010119-t1x9gknd 9644 18 stage stage NN cord-010119-t1x9gknd 9644 19 Pf Pf NNP cord-010119-t1x9gknd 9644 20 - - HYPH cord-010119-t1x9gknd 9644 21 infected infect VBN cord-010119-t1x9gknd 9644 22 red red JJ cord-010119-t1x9gknd 9644 23 blood blood NN cord-010119-t1x9gknd 9644 24 cells cell NNS cord-010119-t1x9gknd 9644 25 ( ( -LRB- cord-010119-t1x9gknd 9644 26 iRBC irbc RB cord-010119-t1x9gknd 9644 27 ) ) -RRB- cord-010119-t1x9gknd 9644 28 . . . cord-010119-t1x9gknd 9645 1 A a DT cord-010119-t1x9gknd 9645 2 pre pre JJ cord-010119-t1x9gknd 9645 3 - - JJ cord-010119-t1x9gknd 9645 4 treatment treatment JJ cord-010119-t1x9gknd 9645 5 sample sample NN cord-010119-t1x9gknd 9645 6 was be VBD cord-010119-t1x9gknd 9645 7 removed remove VBN cord-010119-t1x9gknd 9645 8 prior prior RB cord-010119-t1x9gknd 9645 9 to to IN cord-010119-t1x9gknd 9645 10 addition addition NN cord-010119-t1x9gknd 9645 11 of of IN cord-010119-t1x9gknd 9645 12 amustaline amustaline NN cord-010119-t1x9gknd 9645 13 and and CC cord-010119-t1x9gknd 9645 14 a a DT cord-010119-t1x9gknd 9645 15 post post JJ cord-010119-t1x9gknd 9645 16 - - JJ cord-010119-t1x9gknd 9645 17 treatment treatment JJ cord-010119-t1x9gknd 9645 18 sample sample NN cord-010119-t1x9gknd 9645 19 was be VBD cord-010119-t1x9gknd 9645 20 removed remove VBN cord-010119-t1x9gknd 9645 21 24h 24h NNS cord-010119-t1x9gknd 9645 22 after after IN cord-010119-t1x9gknd 9645 23 amustaline amustaline NN cord-010119-t1x9gknd 9645 24 addition addition NN cord-010119-t1x9gknd 9645 25 to to TO cord-010119-t1x9gknd 9645 26 determine determine VB cord-010119-t1x9gknd 9645 27 the the DT cord-010119-t1x9gknd 9645 28 pre pre JJ cord-010119-t1x9gknd 9645 29 - - JJ cord-010119-t1x9gknd 9645 30 and and CC cord-010119-t1x9gknd 9645 31 posttreatment posttreatment NN cord-010119-t1x9gknd 9645 32 titers titer NNS cord-010119-t1x9gknd 9645 33 to to TO cord-010119-t1x9gknd 9645 34 calculate calculate VB cord-010119-t1x9gknd 9645 35 the the DT cord-010119-t1x9gknd 9645 36 level level NN cord-010119-t1x9gknd 9645 37 of of IN cord-010119-t1x9gknd 9645 38 inactivation inactivation NN cord-010119-t1x9gknd 9645 39 . . . cord-010119-t1x9gknd 9646 1 These these DT cord-010119-t1x9gknd 9646 2 samples sample NNS cord-010119-t1x9gknd 9646 3 were be VBD cord-010119-t1x9gknd 9646 4 serially serially RB cord-010119-t1x9gknd 9646 5 diluted dilute VBN cord-010119-t1x9gknd 9646 6 in in IN cord-010119-t1x9gknd 9646 7 flasks flask NNS cord-010119-t1x9gknd 9646 8 containing contain VBG cord-010119-t1x9gknd 9646 9 medium medium NN cord-010119-t1x9gknd 9646 10 with with IN cord-010119-t1x9gknd 9646 11 5 5 CD cord-010119-t1x9gknd 9646 12 % % NN cord-010119-t1x9gknd 9646 13 fresh fresh JJ cord-010119-t1x9gknd 9646 14 RBCs rbc NNS cord-010119-t1x9gknd 9646 15 . . . cord-010119-t1x9gknd 9647 1 The the DT cord-010119-t1x9gknd 9647 2 diluted diluted JJ cord-010119-t1x9gknd 9647 3 samples sample NNS cord-010119-t1x9gknd 9647 4 were be VBD cord-010119-t1x9gknd 9647 5 used use VBN cord-010119-t1x9gknd 9647 6 to to TO cord-010119-t1x9gknd 9647 7 inoculate inoculate VB cord-010119-t1x9gknd 9647 8 flasks flask NNS cord-010119-t1x9gknd 9647 9 in in IN cord-010119-t1x9gknd 9647 10 quadruplicate quadruplicate NN cord-010119-t1x9gknd 9647 11 and and CC cord-010119-t1x9gknd 9647 12 monitored monitor VBN cord-010119-t1x9gknd 9647 13 for for IN cord-010119-t1x9gknd 9647 14 parasitemia parasitemia NNP cord-010119-t1x9gknd 9647 15 by by IN cord-010119-t1x9gknd 9647 16 counting count VBG cord-010119-t1x9gknd 9647 17 iRBC irbc JJ cord-010119-t1x9gknd 9647 18 in in IN cord-010119-t1x9gknd 9647 19 blood blood NN cord-010119-t1x9gknd 9647 20 smears smear NNS cord-010119-t1x9gknd 9647 21 and and CC cord-010119-t1x9gknd 9647 22 by by IN cord-010119-t1x9gknd 9647 23 flow flow NN cord-010119-t1x9gknd 9647 24 cytometry cytometry NN cord-010119-t1x9gknd 9647 25 . . . cord-010119-t1x9gknd 9648 1 Pretreatment pretreatment NN cord-010119-t1x9gknd 9648 2 cultures culture NNS cord-010119-t1x9gknd 9648 3 were be VBD cord-010119-t1x9gknd 9648 4 terminated terminate VBN cord-010119-t1x9gknd 9648 5 after after IN cord-010119-t1x9gknd 9648 6 reaching reach VBG cord-010119-t1x9gknd 9648 7 > > XX cord-010119-t1x9gknd 9648 8 1 1 CD cord-010119-t1x9gknd 9648 9 % % NN cord-010119-t1x9gknd 9648 10 parasitemia parasitemia NN cord-010119-t1x9gknd 9648 11 , , , cord-010119-t1x9gknd 9648 12 while while IN cord-010119-t1x9gknd 9648 13 no no DT cord-010119-t1x9gknd 9648 14 residual residual JJ cord-010119-t1x9gknd 9648 15 Pf Pf NNP cord-010119-t1x9gknd 9648 16 was be VBD cord-010119-t1x9gknd 9648 17 detected detect VBN cord-010119-t1x9gknd 9648 18 in in IN cord-010119-t1x9gknd 9648 19 post post JJ cord-010119-t1x9gknd 9648 20 - - JJ cord-010119-t1x9gknd 9648 21 treatment treatment JJ cord-010119-t1x9gknd 9648 22 cultures culture NNS cord-010119-t1x9gknd 9648 23 . . . cord-010119-t1x9gknd 9649 1 Log log JJ cord-010119-t1x9gknd 9649 2 reduction reduction NN cord-010119-t1x9gknd 9649 3 was be VBD cord-010119-t1x9gknd 9649 4 calculated calculate VBN cord-010119-t1x9gknd 9649 5 as as IN cord-010119-t1x9gknd 9649 6 the the DT cord-010119-t1x9gknd 9649 7 difference difference NN cord-010119-t1x9gknd 9649 8 between between IN cord-010119-t1x9gknd 9649 9 the the DT cord-010119-t1x9gknd 9649 10 mean mean JJ cord-010119-t1x9gknd 9649 11 titer titer NN cord-010119-t1x9gknd 9649 12 in in IN cord-010119-t1x9gknd 9649 13 pre pre JJ cord-010119-t1x9gknd 9649 14 - - JJ cord-010119-t1x9gknd 9649 15 and and CC cord-010119-t1x9gknd 9649 16 posttreatment posttreatment NN cord-010119-t1x9gknd 9649 17 samples sample NNS cord-010119-t1x9gknd 9649 18 . . . cord-010119-t1x9gknd 9650 1 Results/ Results/ . cord-010119-t1x9gknd 9651 1 Finding finding NN cord-010119-t1x9gknd 9651 2 : : : cord-010119-t1x9gknd 9652 1 Robust robust JJ cord-010119-t1x9gknd 9652 2 inactivation inactivation NN cord-010119-t1x9gknd 9652 3 of of IN cord-010119-t1x9gknd 9652 4 Pf Pf NNP cord-010119-t1x9gknd 9652 5 in in IN cord-010119-t1x9gknd 9652 6 WB WB NNP cord-010119-t1x9gknd 9652 7 was be VBD cord-010119-t1x9gknd 9652 8 achieved achieve VBN cord-010119-t1x9gknd 9652 9 to to IN cord-010119-t1x9gknd 9652 10 the the DT cord-010119-t1x9gknd 9652 11 limit limit NN cord-010119-t1x9gknd 9652 12 of of IN cord-010119-t1x9gknd 9652 13 detection detection NN cord-010119-t1x9gknd 9652 14 , , , cord-010119-t1x9gknd 9652 15 at at IN cord-010119-t1x9gknd 9652 16 > > XX cord-010119-t1x9gknd 9652 17 7.5 7.5 CD cord-010119-t1x9gknd 9652 18 log log NN cord-010119-t1x9gknd 9652 19 10 10 CD cord-010119-t1x9gknd 9652 20 or or CC cord-010119-t1x9gknd 9652 21 > > XX cord-010119-t1x9gknd 9652 22 6.0 6.0 CD cord-010119-t1x9gknd 9652 23 log log NN cord-010119-t1x9gknd 9652 24 10 10 CD cord-010119-t1x9gknd 9653 1 /mL. /mL. . cord-010119-t1x9gknd 9654 1 Conclusion conclusion NN cord-010119-t1x9gknd 9654 2 : : : cord-010119-t1x9gknd 9655 1 Pf Pf NNP cord-010119-t1x9gknd 9655 2 was be VBD cord-010119-t1x9gknd 9655 3 inactivated inactivate VBN cord-010119-t1x9gknd 9655 4 to to IN cord-010119-t1x9gknd 9655 5 the the DT cord-010119-t1x9gknd 9655 6 limit limit NN cord-010119-t1x9gknd 9655 7 of of IN cord-010119-t1x9gknd 9655 8 detection detection NN cord-010119-t1x9gknd 9655 9 in in IN cord-010119-t1x9gknd 9655 10 WB WB NNP cord-010119-t1x9gknd 9655 11 after after IN cord-010119-t1x9gknd 9655 12 treatment treatment NN cord-010119-t1x9gknd 9655 13 with with IN cord-010119-t1x9gknd 9655 14 amustaline amustaline NNP cord-010119-t1x9gknd 9655 15 / / SYM cord-010119-t1x9gknd 9655 16 GSH GSH NNP cord-010119-t1x9gknd 9655 17 , , , cord-010119-t1x9gknd 9655 18 illustrating illustrate VBG cord-010119-t1x9gknd 9655 19 that that IN cord-010119-t1x9gknd 9655 20 the the DT cord-010119-t1x9gknd 9655 21 system system NN cord-010119-t1x9gknd 9655 22 has have VBZ cord-010119-t1x9gknd 9655 23 potential potential JJ cord-010119-t1x9gknd 9655 24 to to TO cord-010119-t1x9gknd 9655 25 mitigate mitigate VB cord-010119-t1x9gknd 9655 26 the the DT cord-010119-t1x9gknd 9655 27 risk risk NN cord-010119-t1x9gknd 9655 28 for for IN cord-010119-t1x9gknd 9655 29 Pf Pf NNP cord-010119-t1x9gknd 9655 30 transfusion transfusion NN cord-010119-t1x9gknd 9655 31 transmission transmission NN cord-010119-t1x9gknd 9655 32 in in IN cord-010119-t1x9gknd 9655 33 endemic endemic JJ cord-010119-t1x9gknd 9655 34 regions region NNS cord-010119-t1x9gknd 9655 35 that that WDT cord-010119-t1x9gknd 9655 36 lack lack VBP cord-010119-t1x9gknd 9655 37 testing test VBG cord-010119-t1x9gknd 9655 38 capacity capacity NN cord-010119-t1x9gknd 9655 39 and and CC cord-010119-t1x9gknd 9655 40 operate operate VBP cord-010119-t1x9gknd 9655 41 under under IN cord-010119-t1x9gknd 9655 42 the the DT cord-010119-t1x9gknd 9655 43 constraint constraint NN cord-010119-t1x9gknd 9655 44 of of IN cord-010119-t1x9gknd 9655 45 a a DT cord-010119-t1x9gknd 9655 46 very very RB cord-010119-t1x9gknd 9655 47 limited limited JJ cord-010119-t1x9gknd 9655 48 blood blood NN cord-010119-t1x9gknd 9655 49 component component NN cord-010119-t1x9gknd 9655 50 supply supply NN cord-010119-t1x9gknd 9655 51 and and CC cord-010119-t1x9gknd 9655 52 rely rely VB cord-010119-t1x9gknd 9655 53 on on IN cord-010119-t1x9gknd 9655 54 WB WB NNP cord-010119-t1x9gknd 9655 55 transfusion transfusion NN cord-010119-t1x9gknd 9655 56 . . . cord-010119-t1x9gknd 9656 1 ( ( -LRB- cord-010119-t1x9gknd 9656 2 This this DT cord-010119-t1x9gknd 9656 3 system system NN cord-010119-t1x9gknd 9656 4 for for IN cord-010119-t1x9gknd 9656 5 WB WB NNP cord-010119-t1x9gknd 9656 6 is be VBZ cord-010119-t1x9gknd 9656 7 not not RB cord-010119-t1x9gknd 9656 8 approved approve VBN cord-010119-t1x9gknd 9656 9 for for IN cord-010119-t1x9gknd 9656 10 commercial commercial JJ cord-010119-t1x9gknd 9656 11 use use NN cord-010119-t1x9gknd 9656 12 ) ) -RRB- cord-010119-t1x9gknd 9656 13 . . . cord-010119-t1x9gknd 9657 1 Increased Increased NNP cord-010119-t1x9gknd 9657 2 Patient Patient NNP cord-010119-t1x9gknd 9657 3 Safety Safety NNP cord-010119-t1x9gknd 9657 4 and and CC cord-010119-t1x9gknd 9657 5 Improved Improved NNP cord-010119-t1x9gknd 9657 6 Inventory Inventory NNP cord-010119-t1x9gknd 9657 7 Management Management NNP cord-010119-t1x9gknd 9657 8 with with IN cord-010119-t1x9gknd 9657 9 7 7 CD cord-010119-t1x9gknd 9657 10 Day Day NNP cord-010119-t1x9gknd 9657 11 Apheresis Apheresis NNP cord-010119-t1x9gknd 9657 12 Platelets platelet NNS cord-010119-t1x9gknd 9658 1 Nancy Nancy NNP cord-010119-t1x9gknd 9658 2 M. M. NNP cord-010119-t1x9gknd 9658 3 Dunbar Dunbar NNP cord-010119-t1x9gknd 9658 4 * * NFP cord-010119-t1x9gknd 9658 5 and and CC cord-010119-t1x9gknd 9658 6 Zbigniew Zbigniew NNP cord-010119-t1x9gknd 9658 7 M. M. NNP cord-010119-t1x9gknd 9658 8 Szczepiorkowski Szczepiorkowski NNP cord-010119-t1x9gknd 9658 9 . . . cord-010119-t1x9gknd 9659 1 Background Background NNP cord-010119-t1x9gknd 9659 2 / / SYM cord-010119-t1x9gknd 9659 3 Case Case NNP cord-010119-t1x9gknd 9659 4 Studies Studies NNPS cord-010119-t1x9gknd 9659 5 : : : cord-010119-t1x9gknd 9660 1 A a DT cord-010119-t1x9gknd 9660 2 pathway pathway NN cord-010119-t1x9gknd 9660 3 currently currently RB cord-010119-t1x9gknd 9660 4 exists exist VBZ cord-010119-t1x9gknd 9660 5 for for IN cord-010119-t1x9gknd 9660 6 apheresis apheresis NN cord-010119-t1x9gknd 9660 7 platelet platelet NN cord-010119-t1x9gknd 9660 8 ( ( -LRB- cord-010119-t1x9gknd 9660 9 AP AP NNP cord-010119-t1x9gknd 9660 10 ) ) -RRB- cord-010119-t1x9gknd 9660 11 outdate outdate JJ cord-010119-t1x9gknd 9660 12 extension extension NN cord-010119-t1x9gknd 9660 13 from from IN cord-010119-t1x9gknd 9660 14 5 5 CD cord-010119-t1x9gknd 9660 15 to to TO cord-010119-t1x9gknd 9660 16 7 7 CD cord-010119-t1x9gknd 9660 17 days day NNS cord-010119-t1x9gknd 9660 18 using use VBG cord-010119-t1x9gknd 9660 19 an an DT cord-010119-t1x9gknd 9660 20 FDA FDA NNP cord-010119-t1x9gknd 9660 21 cleared clear VBN cord-010119-t1x9gknd 9660 22 rapid rapid JJ cord-010119-t1x9gknd 9660 23 test test NN cord-010119-t1x9gknd 9660 24 ( ( -LRB- cord-010119-t1x9gknd 9660 25 RT RT NNP cord-010119-t1x9gknd 9660 26 ) ) -RRB- cord-010119-t1x9gknd 9660 27 . . . cord-010119-t1x9gknd 9661 1 In in IN cord-010119-t1x9gknd 9661 2 February February NNP cord-010119-t1x9gknd 9661 3 2016 2016 CD cord-010119-t1x9gknd 9661 4 , , , cord-010119-t1x9gknd 9661 5 our -PRON- PRP$ cord-010119-t1x9gknd 9661 6 hospital hospital NN cord-010119-t1x9gknd 9661 7 based base VBN cord-010119-t1x9gknd 9661 8 transfusion transfusion NN cord-010119-t1x9gknd 9661 9 service service NN cord-010119-t1x9gknd 9661 10 implemented implement VBD cord-010119-t1x9gknd 9661 11 the the DT cord-010119-t1x9gknd 9661 12 use use NN cord-010119-t1x9gknd 9661 13 of of IN cord-010119-t1x9gknd 9661 14 RT RT NNP cord-010119-t1x9gknd 9661 15 on on IN cord-010119-t1x9gknd 9661 16 day day NN cord-010119-t1x9gknd 9661 17 5 5 CD cord-010119-t1x9gknd 9661 18 , , , cord-010119-t1x9gknd 9661 19 6 6 CD cord-010119-t1x9gknd 9661 20 and and CC cord-010119-t1x9gknd 9661 21 7 7 CD cord-010119-t1x9gknd 9661 22 to to TO cord-010119-t1x9gknd 9661 23 routinely routinely RB cord-010119-t1x9gknd 9661 24 extend extend VB cord-010119-t1x9gknd 9661 25 AP AP NNP cord-010119-t1x9gknd 9661 26 shelf shelf NN cord-010119-t1x9gknd 9661 27 life life NN cord-010119-t1x9gknd 9661 28 to to IN cord-010119-t1x9gknd 9661 29 7 7 CD cord-010119-t1x9gknd 9661 30 days day NNS cord-010119-t1x9gknd 9661 31 . . . cord-010119-t1x9gknd 9662 1 Prior prior RB cord-010119-t1x9gknd 9662 2 to to IN cord-010119-t1x9gknd 9662 3 this this DT cord-010119-t1x9gknd 9662 4 , , , cord-010119-t1x9gknd 9662 5 we -PRON- PRP cord-010119-t1x9gknd 9662 6 tested test VBD cord-010119-t1x9gknd 9662 7 APs APs NNP cord-010119-t1x9gknd 9662 8 by by IN cord-010119-t1x9gknd 9662 9 RT RT NNP cord-010119-t1x9gknd 9662 10 on on IN cord-010119-t1x9gknd 9662 11 day day NN cord-010119-t1x9gknd 9662 12 4 4 CD cord-010119-t1x9gknd 9662 13 and and CC cord-010119-t1x9gknd 9662 14 transfused transfused JJ cord-010119-t1x9gknd 9662 15 day day NN cord-010119-t1x9gknd 9662 16 6 6 CD cord-010119-t1x9gknd 9662 17 or or CC cord-010119-t1x9gknd 9662 18 day day NN cord-010119-t1x9gknd 9662 19 7 7 CD cord-010119-t1x9gknd 9662 20 units unit NNS cord-010119-t1x9gknd 9662 21 with with IN cord-010119-t1x9gknd 9662 22 physician physician NN cord-010119-t1x9gknd 9662 23 approval approval NN cord-010119-t1x9gknd 9662 24 when when WRB cord-010119-t1x9gknd 9662 25 deemed deem VBN cord-010119-t1x9gknd 9662 26 medically medically RB cord-010119-t1x9gknd 9662 27 necessary necessary JJ cord-010119-t1x9gknd 9662 28 . . . cord-010119-t1x9gknd 9663 1 This this DT cord-010119-t1x9gknd 9663 2 report report NN cord-010119-t1x9gknd 9663 3 describes describe VBZ cord-010119-t1x9gknd 9663 4 changes change NNS cord-010119-t1x9gknd 9663 5 observed observe VBN cord-010119-t1x9gknd 9663 6 in in IN cord-010119-t1x9gknd 9663 7 transfusion transfusion NN cord-010119-t1x9gknd 9663 8 practice practice NN cord-010119-t1x9gknd 9663 9 and and CC cord-010119-t1x9gknd 9663 10 platelet platelet NN cord-010119-t1x9gknd 9663 11 inventory inventory NN cord-010119-t1x9gknd 9663 12 management management NN cord-010119-t1x9gknd 9663 13 one one CD cord-010119-t1x9gknd 9663 14 year year NN cord-010119-t1x9gknd 9663 15 following follow VBG cord-010119-t1x9gknd 9663 16 routine routine JJ cord-010119-t1x9gknd 9663 17 use use NN cord-010119-t1x9gknd 9663 18 of of IN cord-010119-t1x9gknd 9663 19 7 7 CD cord-010119-t1x9gknd 9663 20 day day NN cord-010119-t1x9gknd 9663 21 platelets platelet NNS cord-010119-t1x9gknd 9663 22 . . . cord-010119-t1x9gknd 9664 1 Study Study NNP cord-010119-t1x9gknd 9664 2 Design Design NNP cord-010119-t1x9gknd 9664 3 / / SYM cord-010119-t1x9gknd 9664 4 Methods method NNS cord-010119-t1x9gknd 9664 5 : : : cord-010119-t1x9gknd 9665 1 Data datum NNS cord-010119-t1x9gknd 9665 2 were be VBD cord-010119-t1x9gknd 9665 3 obtained obtain VBN cord-010119-t1x9gknd 9665 4 for for IN cord-010119-t1x9gknd 9665 5 two two CD cord-010119-t1x9gknd 9665 6 12-month 12-month JJ cord-010119-t1x9gknd 9665 7 study study NN cord-010119-t1x9gknd 9665 8 periods period NNS cord-010119-t1x9gknd 9665 9 : : : cord-010119-t1x9gknd 9665 10 October October NNP cord-010119-t1x9gknd 9665 11 2014-September 2014-september CD cord-010119-t1x9gknd 9665 12 2015 2015 CD cord-010119-t1x9gknd 9665 13 ( ( -LRB- cord-010119-t1x9gknd 9665 14 pre pre JJ cord-010119-t1x9gknd 9665 15 - - NN cord-010119-t1x9gknd 9665 16 implementation implementation JJ cord-010119-t1x9gknd 9665 17 ) ) -RRB- cord-010119-t1x9gknd 9665 18 and and CC cord-010119-t1x9gknd 9665 19 February February NNP cord-010119-t1x9gknd 9665 20 2016-January 2016-january CD cord-010119-t1x9gknd 9665 21 2017 2017 CD cord-010119-t1x9gknd 9666 1 ( ( -LRB- cord-010119-t1x9gknd 9666 2 post post NN cord-010119-t1x9gknd 9666 3 - - NN cord-010119-t1x9gknd 9666 4 implementation implementation JJ cord-010119-t1x9gknd 9666 5 ) ) -RRB- cord-010119-t1x9gknd 9666 6 . . . cord-010119-t1x9gknd 9667 1 The the DT cord-010119-t1x9gknd 9667 2 interval interval NN cord-010119-t1x9gknd 9667 3 transition transition NN cord-010119-t1x9gknd 9667 4 period period NN cord-010119-t1x9gknd 9667 5 was be VBD cord-010119-t1x9gknd 9667 6 intentionally intentionally RB cord-010119-t1x9gknd 9667 7 excluded exclude VBN cord-010119-t1x9gknd 9667 8 . . . cord-010119-t1x9gknd 9668 1 For for IN cord-010119-t1x9gknd 9668 2 each each DT cord-010119-t1x9gknd 9668 3 study study NN cord-010119-t1x9gknd 9668 4 period period NN cord-010119-t1x9gknd 9668 5 , , , cord-010119-t1x9gknd 9668 6 we -PRON- PRP cord-010119-t1x9gknd 9668 7 determined determine VBD cord-010119-t1x9gknd 9668 8 the the DT cord-010119-t1x9gknd 9668 9 total total JJ cord-010119-t1x9gknd 9668 10 number number NN cord-010119-t1x9gknd 9668 11 of of IN cord-010119-t1x9gknd 9668 12 APs APs NNP cord-010119-t1x9gknd 9668 13 transfused transfuse VBN cord-010119-t1x9gknd 9668 14 , , , cord-010119-t1x9gknd 9668 15 RT RT NNP cord-010119-t1x9gknd 9668 16 status status NN cord-010119-t1x9gknd 9668 17 on on IN cord-010119-t1x9gknd 9668 18 the the DT cord-010119-t1x9gknd 9668 19 day day NN cord-010119-t1x9gknd 9668 20 of of IN cord-010119-t1x9gknd 9668 21 transfusion transfusion NN cord-010119-t1x9gknd 9668 22 , , , cord-010119-t1x9gknd 9668 23 total total JJ cord-010119-t1x9gknd 9668 24 number number NN cord-010119-t1x9gknd 9668 25 of of IN cord-010119-t1x9gknd 9668 26 RTs rt NNS cord-010119-t1x9gknd 9668 27 performed perform VBN cord-010119-t1x9gknd 9668 28 , , , cord-010119-t1x9gknd 9668 29 expired expire VBD cord-010119-t1x9gknd 9668 30 AP AP NNP cord-010119-t1x9gknd 9668 31 units unit NNS cord-010119-t1x9gknd 9668 32 , , , cord-010119-t1x9gknd 9668 33 and and CC cord-010119-t1x9gknd 9668 34 APs APs NNP cord-010119-t1x9gknd 9668 35 obtained obtain VBD cord-010119-t1x9gknd 9668 36 from from IN cord-010119-t1x9gknd 9668 37 suppliers supplier NNS cord-010119-t1x9gknd 9668 38 using use VBG cord-010119-t1x9gknd 9668 39 ad ad NN cord-010119-t1x9gknd 9668 40 - - HYPH cord-010119-t1x9gknd 9668 41 hoc hoc FW cord-010119-t1x9gknd 9668 42 ordering ordering NN cord-010119-t1x9gknd 9668 43 . . . cord-010119-t1x9gknd 9669 1 We -PRON- PRP cord-010119-t1x9gknd 9669 2 also also RB cord-010119-t1x9gknd 9669 3 obtained obtain VBD cord-010119-t1x9gknd 9669 4 hospital hospital NN cord-010119-t1x9gknd 9669 5 data datum NNS cord-010119-t1x9gknd 9669 6 including include VBG cord-010119-t1x9gknd 9669 7 inpatient inpatient JJ cord-010119-t1x9gknd 9669 8 admissions admission NNS cord-010119-t1x9gknd 9669 9 , , , cord-010119-t1x9gknd 9669 10 surgical surgical JJ cord-010119-t1x9gknd 9669 11 volumes volume NNS cord-010119-t1x9gknd 9669 12 , , , cord-010119-t1x9gknd 9669 13 average average JJ cord-010119-t1x9gknd 9669 14 length length NN cord-010119-t1x9gknd 9669 15 of of IN cord-010119-t1x9gknd 9669 16 stay stay NN cord-010119-t1x9gknd 9669 17 and and CC cord-010119-t1x9gknd 9669 18 case case NN cord-010119-t1x9gknd 9669 19 mix mix NN cord-010119-t1x9gknd 9669 20 index index NN cord-010119-t1x9gknd 9669 21 . . . cord-010119-t1x9gknd 9670 1 Results/ Results/ . cord-010119-t1x9gknd 9671 1 Findings finding NNS cord-010119-t1x9gknd 9671 2 : : : cord-010119-t1x9gknd 9672 1 Data datum NNS cord-010119-t1x9gknd 9672 2 are be VBP cord-010119-t1x9gknd 9672 3 shown show VBN cord-010119-t1x9gknd 9672 4 in in IN cord-010119-t1x9gknd 9672 5 Table Table NNP cord-010119-t1x9gknd 9672 6 1 1 CD cord-010119-t1x9gknd 9672 7 . . . cord-010119-t1x9gknd 9673 1 The the DT cord-010119-t1x9gknd 9673 2 number number NN cord-010119-t1x9gknd 9673 3 of of IN cord-010119-t1x9gknd 9673 4 AP AP NNP cord-010119-t1x9gknd 9673 5 transfusions transfusion NNS cord-010119-t1x9gknd 9673 6 increased increase VBD cord-010119-t1x9gknd 9673 7 by by IN cord-010119-t1x9gknd 9673 8 7 7 CD cord-010119-t1x9gknd 9673 9 % % NN cord-010119-t1x9gknd 9673 10 post post NN cord-010119-t1x9gknd 9673 11 - - NN cord-010119-t1x9gknd 9673 12 implementation implementation JJ cord-010119-t1x9gknd 9673 13 , , , cord-010119-t1x9gknd 9673 14 comparable comparable JJ cord-010119-t1x9gknd 9673 15 to to IN cord-010119-t1x9gknd 9673 16 a a DT cord-010119-t1x9gknd 9673 17 4 4 CD cord-010119-t1x9gknd 9673 18 % % NN cord-010119-t1x9gknd 9673 19 increase increase NN cord-010119-t1x9gknd 9673 20 in in IN cord-010119-t1x9gknd 9673 21 inpatient inpatient JJ cord-010119-t1x9gknd 9673 22 admissions admission NNS cord-010119-t1x9gknd 9673 23 and and CC cord-010119-t1x9gknd 9673 24 an an DT cord-010119-t1x9gknd 9673 25 11 11 CD cord-010119-t1x9gknd 9673 26 % % NN cord-010119-t1x9gknd 9673 27 increase increase NN cord-010119-t1x9gknd 9673 28 in in IN cord-010119-t1x9gknd 9673 29 surgical surgical JJ cord-010119-t1x9gknd 9673 30 volumes volume NNS cord-010119-t1x9gknd 9673 31 . . . cord-010119-t1x9gknd 9674 1 The the DT cord-010119-t1x9gknd 9674 2 hospital hospital NN cord-010119-t1x9gknd 9674 3 length length NN cord-010119-t1x9gknd 9674 4 of of IN cord-010119-t1x9gknd 9674 5 stay stay NN cord-010119-t1x9gknd 9674 6 and and CC cord-010119-t1x9gknd 9674 7 case case NN cord-010119-t1x9gknd 9674 8 mix mix NN cord-010119-t1x9gknd 9674 9 index index NN cord-010119-t1x9gknd 9674 10 were be VBD cord-010119-t1x9gknd 9674 11 similar similar JJ cord-010119-t1x9gknd 9674 12 for for IN cord-010119-t1x9gknd 9674 13 both both DT cord-010119-t1x9gknd 9674 14 periods period NNS cord-010119-t1x9gknd 9674 15 . . . cord-010119-t1x9gknd 9675 1 The the DT cord-010119-t1x9gknd 9675 2 average average JJ cord-010119-t1x9gknd 9675 3 number number NN cord-010119-t1x9gknd 9675 4 of of IN cord-010119-t1x9gknd 9675 5 platelet platelet NN cord-010119-t1x9gknd 9675 6 transfusions transfusion NNS cord-010119-t1x9gknd 9675 7 per per IN cord-010119-t1x9gknd 9675 8 patient patient NN cord-010119-t1x9gknd 9675 9 was be VBD cord-010119-t1x9gknd 9675 10 not not RB cord-010119-t1x9gknd 9675 11 statistically statistically RB cord-010119-t1x9gknd 9675 12 different different JJ cord-010119-t1x9gknd 9675 13 ( ( -LRB- cord-010119-t1x9gknd 9675 14 3.16 3.16 CD cord-010119-t1x9gknd 9675 15 pre pre NNP cord-010119-t1x9gknd 9675 16 ; ; : cord-010119-t1x9gknd 9675 17 3.12 3.12 CD cord-010119-t1x9gknd 9675 18 post post NN cord-010119-t1x9gknd 9675 19 , , , cord-010119-t1x9gknd 9675 20 p50.91 p50.91 NNP cord-010119-t1x9gknd 9675 21 ) ) -RRB- cord-010119-t1x9gknd 9675 22 . . . cord-010119-t1x9gknd 9676 1 The the DT cord-010119-t1x9gknd 9676 2 number number NN cord-010119-t1x9gknd 9676 3 of of IN cord-010119-t1x9gknd 9676 4 RTs rt NNS cord-010119-t1x9gknd 9676 5 performed perform VBN cord-010119-t1x9gknd 9676 6 increased increase VBD cord-010119-t1x9gknd 9676 7 by by IN cord-010119-t1x9gknd 9676 8 130 130 CD cord-010119-t1x9gknd 9676 9 % % NN cord-010119-t1x9gknd 9676 10 . . . cord-010119-t1x9gknd 9677 1 The the DT cord-010119-t1x9gknd 9677 2 percentage percentage NN cord-010119-t1x9gknd 9677 3 of of IN cord-010119-t1x9gknd 9677 4 transfused transfuse VBN cord-010119-t1x9gknd 9677 5 units unit NNS cord-010119-t1x9gknd 9677 6 tested test VBN cord-010119-t1x9gknd 9677 7 at at IN cord-010119-t1x9gknd 9677 8 least least JJS cord-010119-t1x9gknd 9677 9 once once RB cord-010119-t1x9gknd 9677 10 by by IN cord-010119-t1x9gknd 9677 11 RT RT NNP cord-010119-t1x9gknd 9677 12 prior prior RB cord-010119-t1x9gknd 9677 13 to to IN cord-010119-t1x9gknd 9677 14 transfusion transfusion NN cord-010119-t1x9gknd 9677 15 increased increase VBN cord-010119-t1x9gknd 9677 16 by by IN cord-010119-t1x9gknd 9677 17 21 21 CD cord-010119-t1x9gknd 9677 18 % % NN cord-010119-t1x9gknd 9677 19 ( ( -LRB- cord-010119-t1x9gknd 9677 20 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 9677 21 ) ) -RRB- cord-010119-t1x9gknd 9677 22 . . . cord-010119-t1x9gknd 9678 1 The the DT cord-010119-t1x9gknd 9678 2 outdate outdate JJ cord-010119-t1x9gknd 9678 3 rate rate NN cord-010119-t1x9gknd 9678 4 decreased decrease VBD cord-010119-t1x9gknd 9678 5 from from IN cord-010119-t1x9gknd 9678 6 5 5 CD cord-010119-t1x9gknd 9678 7 % % NN cord-010119-t1x9gknd 9678 8 to to TO cord-010119-t1x9gknd 9678 9 2 2 CD cord-010119-t1x9gknd 9678 10 % % NN cord-010119-t1x9gknd 9678 11 ( ( -LRB- cord-010119-t1x9gknd 9678 12 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 9678 13 ) ) -RRB- cord-010119-t1x9gknd 9678 14 . . . cord-010119-t1x9gknd 9679 1 Ad ad NN cord-010119-t1x9gknd 9679 2 - - HYPH cord-010119-t1x9gknd 9679 3 hoc hoc FW cord-010119-t1x9gknd 9679 4 ordering ordering NN cord-010119-t1x9gknd 9679 5 decreased decrease VBD cord-010119-t1x9gknd 9679 6 from from IN cord-010119-t1x9gknd 9679 7 21 21 CD cord-010119-t1x9gknd 9679 8 % % NN cord-010119-t1x9gknd 9679 9 to to TO cord-010119-t1x9gknd 9679 10 9 9 CD cord-010119-t1x9gknd 9679 11 % % NN cord-010119-t1x9gknd 9679 12 ( ( -LRB- cord-010119-t1x9gknd 9679 13 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 9679 14 ) ) -RRB- cord-010119-t1x9gknd 9679 15 . . . cord-010119-t1x9gknd 9680 1 Conclusion conclusion NN cord-010119-t1x9gknd 9680 2 : : : cord-010119-t1x9gknd 9680 3 Use Use NNP cord-010119-t1x9gknd 9680 4 of of IN cord-010119-t1x9gknd 9680 5 an an DT cord-010119-t1x9gknd 9680 6 approved approve VBN cord-010119-t1x9gknd 9680 7 RT RT NNP cord-010119-t1x9gknd 9680 8 for for IN cord-010119-t1x9gknd 9680 9 routine routine JJ cord-010119-t1x9gknd 9680 10 AP AP NNP cord-010119-t1x9gknd 9680 11 outdate outdate JJ cord-010119-t1x9gknd 9680 12 extension extension NN cord-010119-t1x9gknd 9680 13 to to IN cord-010119-t1x9gknd 9680 14 day day NN cord-010119-t1x9gknd 9680 15 7 7 CD cord-010119-t1x9gknd 9680 16 was be VBD cord-010119-t1x9gknd 9680 17 associated associate VBN cord-010119-t1x9gknd 9680 18 with with IN cord-010119-t1x9gknd 9680 19 increased increased JJ cord-010119-t1x9gknd 9680 20 patient patient JJ cord-010119-t1x9gknd 9680 21 safety safety NN cord-010119-t1x9gknd 9680 22 as as IN cord-010119-t1x9gknd 9680 23 more more JJR cord-010119-t1x9gknd 9680 24 transfused transfuse VBN cord-010119-t1x9gknd 9680 25 units unit NNS cord-010119-t1x9gknd 9680 26 underwent undergo VBD cord-010119-t1x9gknd 9680 27 secondary secondary JJ cord-010119-t1x9gknd 9680 28 testing testing NN cord-010119-t1x9gknd 9680 29 prior prior RB cord-010119-t1x9gknd 9680 30 to to IN cord-010119-t1x9gknd 9680 31 transfusion transfusion NN cord-010119-t1x9gknd 9680 32 . . . cord-010119-t1x9gknd 9681 1 Increased increase VBN cord-010119-t1x9gknd 9681 2 cost cost NN cord-010119-t1x9gknd 9681 3 of of IN cord-010119-t1x9gknd 9681 4 RT RT NNP cord-010119-t1x9gknd 9681 5 was be VBD cord-010119-t1x9gknd 9681 6 offset offset VBN cord-010119-t1x9gknd 9681 7 by by IN cord-010119-t1x9gknd 9681 8 reduced reduce VBN cord-010119-t1x9gknd 9681 9 AP AP NNP cord-010119-t1x9gknd 9681 10 waste waste NN cord-010119-t1x9gknd 9681 11 and and CC cord-010119-t1x9gknd 9681 12 less less RBR cord-010119-t1x9gknd 9681 13 frequent frequent JJ cord-010119-t1x9gknd 9681 14 need need NN cord-010119-t1x9gknd 9681 15 for for IN cord-010119-t1x9gknd 9681 16 ad ad NN cord-010119-t1x9gknd 9681 17 - - HYPH cord-010119-t1x9gknd 9681 18 hoc hoc FW cord-010119-t1x9gknd 9681 19 ordering ordering NN cord-010119-t1x9gknd 9681 20 . . . cord-010119-t1x9gknd 9682 1 Sheila Sheila NNP cord-010119-t1x9gknd 9682 2 O'Brien O'Brien NNP cord-010119-t1x9gknd 9682 3 * * NFP cord-010119-t1x9gknd 9682 4 1 1 CD cord-010119-t1x9gknd 9682 5 , , , cord-010119-t1x9gknd 9682 6 Vito Vito NNP cord-010119-t1x9gknd 9682 7 Scalia Scalia NNP cord-010119-t1x9gknd 9682 8 1 1 CD cord-010119-t1x9gknd 9682 9 , , , cord-010119-t1x9gknd 9682 10 Carla Carla NNP cord-010119-t1x9gknd 9682 11 Osiowy Osiowy NNP cord-010119-t1x9gknd 9682 12 2 2 CD cord-010119-t1x9gknd 9682 13 , , , cord-010119-t1x9gknd 9682 14 Michael Michael NNP cord-010119-t1x9gknd 9682 15 Carpenter Carpenter NNP cord-010119-t1x9gknd 9682 16 2 2 CD cord-010119-t1x9gknd 9682 17 , , , cord-010119-t1x9gknd 9682 18 Anton Anton NNP cord-010119-t1x9gknd 9682 19 Andonov Andonov NNP cord-010119-t1x9gknd 9682 20 2 2 CD cord-010119-t1x9gknd 9682 21 and and CC cord-010119-t1x9gknd 9682 22 Margaret Margaret NNP cord-010119-t1x9gknd 9682 23 Fearon Fearon NNP cord-010119-t1x9gknd 9682 24 1 1 CD cord-010119-t1x9gknd 9682 25 . . . cord-010119-t1x9gknd 9682 26 1 1 CD cord-010119-t1x9gknd 9682 27 Canadian Canadian NNP cord-010119-t1x9gknd 9682 28 Blood Blood NNP cord-010119-t1x9gknd 9682 29 Services Services NNPS cord-010119-t1x9gknd 9682 30 , , , cord-010119-t1x9gknd 9682 31 2 2 CD cord-010119-t1x9gknd 9682 32 Public Public NNP cord-010119-t1x9gknd 9682 33 Health Health NNP cord-010119-t1x9gknd 9682 34 Agency Agency NNP cord-010119-t1x9gknd 9682 35 of of IN cord-010119-t1x9gknd 9682 36 Canada Canada NNP cord-010119-t1x9gknd 9682 37 Background Background NNP cord-010119-t1x9gknd 9682 38 / / SYM cord-010119-t1x9gknd 9682 39 Case Case NNP cord-010119-t1x9gknd 9682 40 Studies Studies NNPS cord-010119-t1x9gknd 9682 41 : : : cord-010119-t1x9gknd 9682 42 The the DT cord-010119-t1x9gknd 9682 43 rates rate NNS cord-010119-t1x9gknd 9682 44 of of IN cord-010119-t1x9gknd 9682 45 hepatitis hepatitis NN cord-010119-t1x9gknd 9682 46 B B NNP cord-010119-t1x9gknd 9682 47 ( ( -LRB- cord-010119-t1x9gknd 9682 48 HBV HBV NNP cord-010119-t1x9gknd 9682 49 ) ) -RRB- cord-010119-t1x9gknd 9682 50 and and CC cord-010119-t1x9gknd 9682 51 hepatitis hepatitis NNP cord-010119-t1x9gknd 9682 52 C C NNP cord-010119-t1x9gknd 9682 53 virus virus NN cord-010119-t1x9gknd 9682 54 ( ( -LRB- cord-010119-t1x9gknd 9682 55 HCV HCV NNP cord-010119-t1x9gknd 9682 56 ) ) -RRB- cord-010119-t1x9gknd 9682 57 positive positive JJ cord-010119-t1x9gknd 9682 58 donations donation NNS cord-010119-t1x9gknd 9682 59 are be VBP cord-010119-t1x9gknd 9682 60 low low JJ cord-010119-t1x9gknd 9682 61 ( ( -LRB- cord-010119-t1x9gknd 9682 62 6.6 6.6 CD cord-010119-t1x9gknd 9682 63 and and CC cord-010119-t1x9gknd 9682 64 4.9 4.9 CD cord-010119-t1x9gknd 9682 65 per per IN cord-010119-t1x9gknd 9682 66 100,000 100,000 CD cord-010119-t1x9gknd 9682 67 donations donation NNS cord-010119-t1x9gknd 9682 68 , , , cord-010119-t1x9gknd 9682 69 respectively respectively RB cord-010119-t1x9gknd 9682 70 ) ) -RRB- cord-010119-t1x9gknd 9682 71 and and CC cord-010119-t1x9gknd 9682 72 most most JJS cord-010119-t1x9gknd 9682 73 are be VBP cord-010119-t1x9gknd 9682 74 among among IN cord-010119-t1x9gknd 9682 75 first first JJ cord-010119-t1x9gknd 9682 76 time time NN cord-010119-t1x9gknd 9682 77 donors donor NNS cord-010119-t1x9gknd 9682 78 . . . cord-010119-t1x9gknd 9683 1 We -PRON- PRP cord-010119-t1x9gknd 9683 2 aimed aim VBD cord-010119-t1x9gknd 9683 3 to to TO cord-010119-t1x9gknd 9683 4 determine determine VB cord-010119-t1x9gknd 9683 5 the the DT cord-010119-t1x9gknd 9683 6 frequency frequency NN cord-010119-t1x9gknd 9683 7 of of IN cord-010119-t1x9gknd 9683 8 various various JJ cord-010119-t1x9gknd 9683 9 genotypes genotype NNS cord-010119-t1x9gknd 9683 10 of of IN cord-010119-t1x9gknd 9683 11 HBV HBV NNP cord-010119-t1x9gknd 9683 12 and and CC cord-010119-t1x9gknd 9683 13 HCV HCV NNP cord-010119-t1x9gknd 9683 14 in in IN cord-010119-t1x9gknd 9683 15 Canadian canadian JJ cord-010119-t1x9gknd 9683 16 blood blood NN cord-010119-t1x9gknd 9683 17 donors donor NNS cord-010119-t1x9gknd 9683 18 confirmed confirm VBD cord-010119-t1x9gknd 9683 19 positive positive JJ cord-010119-t1x9gknd 9683 20 for for IN cord-010119-t1x9gknd 9683 21 HBV HBV NNP cord-010119-t1x9gknd 9683 22 and and CC cord-010119-t1x9gknd 9683 23 HCV HCV NNP cord-010119-t1x9gknd 9683 24 . . . cord-010119-t1x9gknd 9684 1 Study Study NNP cord-010119-t1x9gknd 9684 2 Design Design NNP cord-010119-t1x9gknd 9684 3 / / SYM cord-010119-t1x9gknd 9684 4 Methods method NNS cord-010119-t1x9gknd 9684 5 : : : cord-010119-t1x9gknd 9685 1 In in IN cord-010119-t1x9gknd 9685 2 2011 2011 CD cord-010119-t1x9gknd 9685 3 the the DT cord-010119-t1x9gknd 9685 4 Roche Roche NNP cord-010119-t1x9gknd 9685 5 multiplex multiplex NN cord-010119-t1x9gknd 9685 6 assay assay NN cord-010119-t1x9gknd 9685 7 ( ( -LRB- cord-010119-t1x9gknd 9685 8 HCV HCV NNP cord-010119-t1x9gknd 9685 9 / / SYM cord-010119-t1x9gknd 9685 10 HIV/ HIV/ NNP cord-010119-t1x9gknd 9685 11 HBV HBV NNP cord-010119-t1x9gknd 9685 12 ) ) -RRB- cord-010119-t1x9gknd 9685 13 was be VBD cord-010119-t1x9gknd 9685 14 implemented implement VBN cord-010119-t1x9gknd 9685 15 in in IN cord-010119-t1x9gknd 9685 16 minipools minipool NNS cord-010119-t1x9gknd 9685 17 of of IN cord-010119-t1x9gknd 9685 18 6 6 CD cord-010119-t1x9gknd 9685 19 units unit NNS cord-010119-t1x9gknd 9685 20 . . . cord-010119-t1x9gknd 9686 1 HCV HCV NNP cord-010119-t1x9gknd 9686 2 NAT NAT NNP cord-010119-t1x9gknd 9686 3 was be VBD cord-010119-t1x9gknd 9686 4 in in IN cord-010119-t1x9gknd 9686 5 place place NN cord-010119-t1x9gknd 9686 6 since since IN cord-010119-t1x9gknd 9686 7 1999 1999 CD cord-010119-t1x9gknd 9686 8 ( ( -LRB- cord-010119-t1x9gknd 9686 9 using use VBG cord-010119-t1x9gknd 9686 10 minipools minipool NNS cord-010119-t1x9gknd 9686 11 of of IN cord-010119-t1x9gknd 9686 12 24 24 CD cord-010119-t1x9gknd 9686 13 ) ) -RRB- cord-010119-t1x9gknd 9686 14 but but CC cord-010119-t1x9gknd 9686 15 this this DT cord-010119-t1x9gknd 9686 16 is be VBZ cord-010119-t1x9gknd 9686 17 the the DT cord-010119-t1x9gknd 9686 18 first first JJ cord-010119-t1x9gknd 9686 19 time time NN cord-010119-t1x9gknd 9686 20 donors donor NNS cord-010119-t1x9gknd 9686 21 have have VBP cord-010119-t1x9gknd 9686 22 been be VBN cord-010119-t1x9gknd 9686 23 screened screen VBN cord-010119-t1x9gknd 9686 24 by by IN cord-010119-t1x9gknd 9686 25 HBV HBV NNP cord-010119-t1x9gknd 9686 26 NAT NAT NNP cord-010119-t1x9gknd 9686 27 . . . cord-010119-t1x9gknd 9687 1 HBsAg HBsAg NNP cord-010119-t1x9gknd 9687 2 , , , cord-010119-t1x9gknd 9687 3 anti anti JJ cord-010119-t1x9gknd 9687 4 - - JJ cord-010119-t1x9gknd 9687 5 HBc hbc JJ cord-010119-t1x9gknd 9687 6 and and CC cord-010119-t1x9gknd 9687 7 anti anti NNP cord-010119-t1x9gknd 9687 8 - - NNP cord-010119-t1x9gknd 9687 9 HCV HCV NNP cord-010119-t1x9gknd 9687 10 were be VBD cord-010119-t1x9gknd 9687 11 tested test VBN cord-010119-t1x9gknd 9687 12 using use VBG cord-010119-t1x9gknd 9687 13 the the DT cord-010119-t1x9gknd 9687 14 Abbott Abbott NNP cord-010119-t1x9gknd 9687 15 PRISM PRISM NNP cord-010119-t1x9gknd 9687 16 assay assay NN cord-010119-t1x9gknd 9687 17 . . . cord-010119-t1x9gknd 9688 1 Confirmatory confirmatory JJ cord-010119-t1x9gknd 9688 2 testing testing NN cord-010119-t1x9gknd 9688 3 for for IN cord-010119-t1x9gknd 9688 4 HBsAg HBsAg NNP cord-010119-t1x9gknd 9688 5 was be VBD cord-010119-t1x9gknd 9688 6 by by IN cord-010119-t1x9gknd 9688 7 the the DT cord-010119-t1x9gknd 9688 8 PRISM prism NN cord-010119-t1x9gknd 9688 9 neutralization neutralization NN cord-010119-t1x9gknd 9688 10 assay assay NN cord-010119-t1x9gknd 9688 11 . . . cord-010119-t1x9gknd 9689 1 Anti Anti NNP cord-010119-t1x9gknd 9689 2 - - JJ cord-010119-t1x9gknd 9689 3 HCV HCV NNP cord-010119-t1x9gknd 9689 4 repeat repeat NN cord-010119-t1x9gknd 9689 5 reactivity reactivity NN cord-010119-t1x9gknd 9689 6 was be VBD cord-010119-t1x9gknd 9689 7 confirmed confirm VBN cord-010119-t1x9gknd 9689 8 by by IN cord-010119-t1x9gknd 9689 9 the the DT cord-010119-t1x9gknd 9689 10 Inno Inno NNP cord-010119-t1x9gknd 9689 11 - - HYPH cord-010119-t1x9gknd 9689 12 Lia Lia NNP cord-010119-t1x9gknd 9689 13 HCV HCV NNP cord-010119-t1x9gknd 9689 14 Score Score NNP cord-010119-t1x9gknd 9689 15 Line Line NNP cord-010119-t1x9gknd 9689 16 Immunoassay Immunoassay NNP cord-010119-t1x9gknd 9689 17 . . . cord-010119-t1x9gknd 9690 1 Since since IN cord-010119-t1x9gknd 9690 2 March March NNP cord-010119-t1x9gknd 9690 3 2016 2016 CD cord-010119-t1x9gknd 9690 4 all all DT cord-010119-t1x9gknd 9690 5 samples sample NNS cord-010119-t1x9gknd 9690 6 testing test VBG cord-010119-t1x9gknd 9690 7 HBV HBV NNP cord-010119-t1x9gknd 9690 8 NAT NAT NNP cord-010119-t1x9gknd 9690 9 positive positive JJ cord-010119-t1x9gknd 9690 10 , , , cord-010119-t1x9gknd 9690 11 or or CC cord-010119-t1x9gknd 9690 12 confirmed confirm VBD cord-010119-t1x9gknd 9690 13 positive positive JJ cord-010119-t1x9gknd 9690 14 for for IN cord-010119-t1x9gknd 9690 15 HBsAg hbsag ADD cord-010119-t1x9gknd 9690 16 and and CC cord-010119-t1x9gknd 9690 17 all all DT cord-010119-t1x9gknd 9690 18 HCV HCV NNP cord-010119-t1x9gknd 9690 19 NAT NAT NNP cord-010119-t1x9gknd 9690 20 positive positive JJ cord-010119-t1x9gknd 9690 21 or or CC cord-010119-t1x9gknd 9690 22 anti anti JJ cord-010119-t1x9gknd 9690 23 - - JJ cord-010119-t1x9gknd 9690 24 HCV HCV NNP cord-010119-t1x9gknd 9690 25 confirmed confirm VBD cord-010119-t1x9gknd 9690 26 positive positive JJ cord-010119-t1x9gknd 9690 27 samples sample NNS cord-010119-t1x9gknd 9690 28 were be VBD cord-010119-t1x9gknd 9690 29 considered consider VBN cord-010119-t1x9gknd 9690 30 positive positive JJ cord-010119-t1x9gknd 9690 31 and and CC cord-010119-t1x9gknd 9690 32 samples sample NNS cord-010119-t1x9gknd 9690 33 were be VBD cord-010119-t1x9gknd 9690 34 sent send VBN cord-010119-t1x9gknd 9690 35 to to IN cord-010119-t1x9gknd 9690 36 PHAC PHAC NNP cord-010119-t1x9gknd 9690 37 for for IN cord-010119-t1x9gknd 9690 38 sequencing sequencing NN cord-010119-t1x9gknd 9690 39 . . . cord-010119-t1x9gknd 9691 1 A a DT cord-010119-t1x9gknd 9691 2 sample sample NN cord-010119-t1x9gknd 9691 3 from from IN cord-010119-t1x9gknd 9691 4 each each DT cord-010119-t1x9gknd 9691 5 positive positive JJ cord-010119-t1x9gknd 9691 6 donation donation NN cord-010119-t1x9gknd 9691 7 was be VBD cord-010119-t1x9gknd 9691 8 aliquoted aliquote VBN cord-010119-t1x9gknd 9691 9 and and CC cord-010119-t1x9gknd 9691 10 frozen freeze VBN cord-010119-t1x9gknd 9691 11 at at IN cord-010119-t1x9gknd 9691 12 -20 -20 . cord-010119-t1x9gknd 9692 1 o o UH cord-010119-t1x9gknd 9692 2 C. C. NNP cord-010119-t1x9gknd 9692 3 Genotyping Genotyping NNP cord-010119-t1x9gknd 9692 4 was be VBD cord-010119-t1x9gknd 9692 5 carried carry VBN cord-010119-t1x9gknd 9692 6 out out RP cord-010119-t1x9gknd 9692 7 by by IN cord-010119-t1x9gknd 9692 8 sequence sequence NN cord-010119-t1x9gknd 9692 9 and and CC cord-010119-t1x9gknd 9692 10 phylogenetic phylogenetic JJ cord-010119-t1x9gknd 9692 11 analysis analysis NN cord-010119-t1x9gknd 9692 12 of of IN cord-010119-t1x9gknd 9692 13 the the DT cord-010119-t1x9gknd 9692 14 HBV HBV NNP cord-010119-t1x9gknd 9692 15 surface surface NN cord-010119-t1x9gknd 9692 16 antigen antigen NN cord-010119-t1x9gknd 9692 17 coding code VBG cord-010119-t1x9gknd 9692 18 region region NN cord-010119-t1x9gknd 9692 19 . . . cord-010119-t1x9gknd 9693 1 HCV HCV NNP cord-010119-t1x9gknd 9693 2 viral viral JJ cord-010119-t1x9gknd 9693 3 RNA RNA NNP cord-010119-t1x9gknd 9693 4 was be VBD cord-010119-t1x9gknd 9693 5 extracted extract VBN cord-010119-t1x9gknd 9693 6 and and CC cord-010119-t1x9gknd 9693 7 subjected subject VBN cord-010119-t1x9gknd 9693 8 to to TO cord-010119-t1x9gknd 9693 9 reverse reverse VB cord-010119-t1x9gknd 9693 10 transcription transcription NN cord-010119-t1x9gknd 9693 11 and and CC cord-010119-t1x9gknd 9693 12 PCR pcr NN cord-010119-t1x9gknd 9693 13 amplification amplification NN cord-010119-t1x9gknd 9693 14 in in IN cord-010119-t1x9gknd 9693 15 the the DT cord-010119-t1x9gknd 9693 16 5 5 CD cord-010119-t1x9gknd 9693 17 ' ' POS cord-010119-t1x9gknd 9693 18 NTR NTR NNP cord-010119-t1x9gknd 9693 19 - - HYPH cord-010119-t1x9gknd 9693 20 E1 E1 NNP cord-010119-t1x9gknd 9693 21 and and CC cord-010119-t1x9gknd 9693 22 NS5B NS5B NNP cord-010119-t1x9gknd 9693 23 regions region NNS cord-010119-t1x9gknd 9693 24 . . . cord-010119-t1x9gknd 9694 1 Sanger Sanger NNP cord-010119-t1x9gknd 9694 2 sequencing sequencing NN cord-010119-t1x9gknd 9694 3 of of IN cord-010119-t1x9gknd 9694 4 these these DT cord-010119-t1x9gknd 9694 5 regions region NNS cord-010119-t1x9gknd 9694 6 represents represent VBZ cord-010119-t1x9gknd 9694 7 approximately approximately RB cord-010119-t1x9gknd 9694 8 15 15 CD cord-010119-t1x9gknd 9694 9 % % NN cord-010119-t1x9gknd 9694 10 of of IN cord-010119-t1x9gknd 9694 11 the the DT cord-010119-t1x9gknd 9694 12 genome genome NN cord-010119-t1x9gknd 9694 13 . . . cord-010119-t1x9gknd 9695 1 Results result NNS cord-010119-t1x9gknd 9695 2 / / SYM cord-010119-t1x9gknd 9695 3 Findings finding NNS cord-010119-t1x9gknd 9695 4 : : : cord-010119-t1x9gknd 9696 1 All all DT cord-010119-t1x9gknd 9696 2 confirmed confirm VBD cord-010119-t1x9gknd 9696 3 positive positive JJ cord-010119-t1x9gknd 9696 4 donations donation NNS cord-010119-t1x9gknd 9696 5 were be VBD cord-010119-t1x9gknd 9696 6 whole whole JJ cord-010119-t1x9gknd 9696 7 blood blood NN cord-010119-t1x9gknd 9696 8 donations donation NNS cord-010119-t1x9gknd 9696 9 . . . cord-010119-t1x9gknd 9697 1 There there EX cord-010119-t1x9gknd 9697 2 were be VBD cord-010119-t1x9gknd 9697 3 42 42 CD cord-010119-t1x9gknd 9697 4 HBV HBV NNP cord-010119-t1x9gknd 9697 5 positive positive JJ cord-010119-t1x9gknd 9697 6 donations donation NNS cord-010119-t1x9gknd 9697 7 . . . cord-010119-t1x9gknd 9698 1 Of of IN cord-010119-t1x9gknd 9698 2 these these DT cord-010119-t1x9gknd 9698 3 , , , cord-010119-t1x9gknd 9698 4 37 37 CD cord-010119-t1x9gknd 9698 5 had have VBD cord-010119-t1x9gknd 9698 6 tested test VBN cord-010119-t1x9gknd 9698 7 HBV HBV NNP cord-010119-t1x9gknd 9698 8 NAT NAT NNP cord-010119-t1x9gknd 9698 9 positive positive JJ cord-010119-t1x9gknd 9698 10 . . . cord-010119-t1x9gknd 9699 1 Genotypes genotype NNS cord-010119-t1x9gknd 9699 2 were be VBD cord-010119-t1x9gknd 9699 3 8 8 CD cord-010119-t1x9gknd 9699 4 type type NN cord-010119-t1x9gknd 9699 5 A a NN cord-010119-t1x9gknd 9699 6 , , , cord-010119-t1x9gknd 9699 7 6 6 CD cord-010119-t1x9gknd 9699 8 B b NN cord-010119-t1x9gknd 9699 9 , , , cord-010119-t1x9gknd 9699 10 4 4 CD cord-010119-t1x9gknd 9699 11 C C NNP cord-010119-t1x9gknd 9699 12 , , , cord-010119-t1x9gknd 9699 13 17 17 CD cord-010119-t1x9gknd 9699 14 D d NN cord-010119-t1x9gknd 9699 15 and and CC cord-010119-t1x9gknd 9700 1 2 2 LS cord-010119-t1x9gknd 9700 2 E. E. NNP cord-010119-t1x9gknd 9700 3 There there EX cord-010119-t1x9gknd 9700 4 were be VBD cord-010119-t1x9gknd 9700 5 5 5 CD cord-010119-t1x9gknd 9700 6 samples sample NNS cord-010119-t1x9gknd 9700 7 HBV HBV NNP cord-010119-t1x9gknd 9700 8 NAT NAT NNP cord-010119-t1x9gknd 9700 9 negative negative JJ cord-010119-t1x9gknd 9700 10 but but CC cord-010119-t1x9gknd 9701 1 HBsAg HBsAg NNP cord-010119-t1x9gknd 9701 2 positive positive JJ cord-010119-t1x9gknd 9702 1 ( ( -LRB- cord-010119-t1x9gknd 9702 2 2 2 CD cord-010119-t1x9gknd 9702 3 were be VBD cord-010119-t1x9gknd 9702 4 anti anti JJ cord-010119-t1x9gknd 9702 5 - - JJ cord-010119-t1x9gknd 9702 6 HBc hbc JJ cord-010119-t1x9gknd 9702 7 reactive reactive JJ cord-010119-t1x9gknd 9702 8 ) ) -RRB- cord-010119-t1x9gknd 9702 9 . . . cord-010119-t1x9gknd 9703 1 Of of IN cord-010119-t1x9gknd 9703 2 these these DT cord-010119-t1x9gknd 9703 3 , , , cord-010119-t1x9gknd 9703 4 4 4 CD cord-010119-t1x9gknd 9703 5 could could MD cord-010119-t1x9gknd 9703 6 not not RB cord-010119-t1x9gknd 9703 7 be be VB cord-010119-t1x9gknd 9703 8 sequenced sequence VBN cord-010119-t1x9gknd 9703 9 and and CC cord-010119-t1x9gknd 9703 10 one one CD cord-010119-t1x9gknd 9703 11 was be VBD cord-010119-t1x9gknd 9703 12 genotype genotype NN cord-010119-t1x9gknd 9703 13 A a NN cord-010119-t1x9gknd 9703 14 ( ( -LRB- cord-010119-t1x9gknd 9703 15 also also RB cord-010119-t1x9gknd 9703 16 anti anti JJ cord-010119-t1x9gknd 9703 17 - - JJ cord-010119-t1x9gknd 9703 18 HBc hbc JJ cord-010119-t1x9gknd 9703 19 reactive reactive JJ cord-010119-t1x9gknd 9703 20 ) ) -RRB- cord-010119-t1x9gknd 9703 21 . . . cord-010119-t1x9gknd 9704 1 There there EX cord-010119-t1x9gknd 9704 2 were be VBD cord-010119-t1x9gknd 9704 3 30 30 CD cord-010119-t1x9gknd 9704 4 samples sample NNS cord-010119-t1x9gknd 9704 5 considered consider VBN cord-010119-t1x9gknd 9704 6 HCV HCV NNP cord-010119-t1x9gknd 9704 7 positive positive JJ cord-010119-t1x9gknd 9704 8 . . . cord-010119-t1x9gknd 9705 1 Of of IN cord-010119-t1x9gknd 9705 2 these these DT cord-010119-t1x9gknd 9705 3 , , , cord-010119-t1x9gknd 9705 4 17 17 CD cord-010119-t1x9gknd 9705 5 samples sample NNS cord-010119-t1x9gknd 9705 6 were be VBD cord-010119-t1x9gknd 9705 7 HCV HCV NNP cord-010119-t1x9gknd 9705 8 NAT NAT NNP cord-010119-t1x9gknd 9705 9 positive positive JJ cord-010119-t1x9gknd 9705 10 . . . cord-010119-t1x9gknd 9706 1 Genotypes genotype NNS cord-010119-t1x9gknd 9706 2 were be VBD cord-010119-t1x9gknd 9706 3 5 5 CD cord-010119-t1x9gknd 9706 4 type type NN cord-010119-t1x9gknd 9706 5 1a 1a NN cord-010119-t1x9gknd 9706 6 , , , cord-010119-t1x9gknd 9706 7 3 3 CD cord-010119-t1x9gknd 9706 8 1b 1b CD cord-010119-t1x9gknd 9706 9 , , , cord-010119-t1x9gknd 9706 10 3 3 CD cord-010119-t1x9gknd 9706 11 2c 2c NNS cord-010119-t1x9gknd 9706 12 , , , cord-010119-t1x9gknd 9706 13 2 2 CD cord-010119-t1x9gknd 9706 14 2b 2b CD cord-010119-t1x9gknd 9706 15 and and CC cord-010119-t1x9gknd 9706 16 4 4 CD cord-010119-t1x9gknd 9706 17 3a 3a NNP cord-010119-t1x9gknd 9706 18 . . . cord-010119-t1x9gknd 9707 1 There there EX cord-010119-t1x9gknd 9707 2 were be VBD cord-010119-t1x9gknd 9707 3 also also RB cord-010119-t1x9gknd 9707 4 13 13 CD cord-010119-t1x9gknd 9707 5 samples sample NNS cord-010119-t1x9gknd 9707 6 HCV HCV NNP cord-010119-t1x9gknd 9707 7 NAT NAT NNP cord-010119-t1x9gknd 9707 8 negative negative JJ cord-010119-t1x9gknd 9707 9 but but CC cord-010119-t1x9gknd 9707 10 anti anti JJ cord-010119-t1x9gknd 9707 11 - - JJ cord-010119-t1x9gknd 9707 12 HCV HCV NNP cord-010119-t1x9gknd 9707 13 positive positive JJ cord-010119-t1x9gknd 9707 14 . . . cord-010119-t1x9gknd 9708 1 None none NN cord-010119-t1x9gknd 9708 2 of of IN cord-010119-t1x9gknd 9708 3 these these DT cord-010119-t1x9gknd 9708 4 could could MD cord-010119-t1x9gknd 9708 5 be be VB cord-010119-t1x9gknd 9708 6 sequenced sequence VBN cord-010119-t1x9gknd 9708 7 . . . cord-010119-t1x9gknd 9709 1 Conclusion conclusion NN cord-010119-t1x9gknd 9709 2 : : : cord-010119-t1x9gknd 9710 1 The the DT cord-010119-t1x9gknd 9710 2 first first JJ cord-010119-t1x9gknd 9710 3 8 8 CD cord-010119-t1x9gknd 9710 4 months month NNS cord-010119-t1x9gknd 9710 5 of of IN cord-010119-t1x9gknd 9710 6 molecular molecular JJ cord-010119-t1x9gknd 9710 7 surveillance surveillance NN cord-010119-t1x9gknd 9710 8 show show VBP cord-010119-t1x9gknd 9710 9 a a DT cord-010119-t1x9gknd 9710 10 range range NN cord-010119-t1x9gknd 9710 11 of of IN cord-010119-t1x9gknd 9710 12 genotypes genotype NNS cord-010119-t1x9gknd 9710 13 for for IN cord-010119-t1x9gknd 9710 14 HBV HBV NNP cord-010119-t1x9gknd 9710 15 and and CC cord-010119-t1x9gknd 9710 16 HCV HCV NNP cord-010119-t1x9gknd 9710 17 for for IN cord-010119-t1x9gknd 9710 18 samples sample NNS cord-010119-t1x9gknd 9710 19 identified identify VBN cord-010119-t1x9gknd 9710 20 as as IN cord-010119-t1x9gknd 9710 21 NAT NAT NNP cord-010119-t1x9gknd 9710 22 positive positive JJ cord-010119-t1x9gknd 9710 23 . . . cord-010119-t1x9gknd 9711 1 To to IN cord-010119-t1x9gknd 9711 2 date date VB cord-010119-t1x9gknd 9711 3 no no DT cord-010119-t1x9gknd 9711 4 samples sample NNS cord-010119-t1x9gknd 9711 5 that that WDT cord-010119-t1x9gknd 9711 6 were be VBD cord-010119-t1x9gknd 9711 7 NAT NAT NNP cord-010119-t1x9gknd 9711 8 negative negative JJ cord-010119-t1x9gknd 9711 9 anti anti JJ cord-010119-t1x9gknd 9711 10 - - JJ cord-010119-t1x9gknd 9711 11 HCV HCV NNP cord-010119-t1x9gknd 9711 12 reactive reactive NN cord-010119-t1x9gknd 9711 13 could could MD cord-010119-t1x9gknd 9711 14 be be VB cord-010119-t1x9gknd 9711 15 sequenced sequence VBN cord-010119-t1x9gknd 9711 16 , , , cord-010119-t1x9gknd 9711 17 however however RB cord-010119-t1x9gknd 9711 18 one one CD cord-010119-t1x9gknd 9711 19 NAT NAT NNP cord-010119-t1x9gknd 9711 20 negative negative JJ cord-010119-t1x9gknd 9711 21 sample sample NN cord-010119-t1x9gknd 9711 22 that that WDT cord-010119-t1x9gknd 9711 23 was be VBD cord-010119-t1x9gknd 9711 24 positive positive JJ cord-010119-t1x9gknd 9711 25 for for IN cord-010119-t1x9gknd 9711 26 HBsAg hbsag ADD cord-010119-t1x9gknd 9711 27 and and CC cord-010119-t1x9gknd 9711 28 anti anti JJ cord-010119-t1x9gknd 9711 29 - - JJ cord-010119-t1x9gknd 9711 30 HBc hbc JJ cord-010119-t1x9gknd 9711 31 reactive reactive NN cord-010119-t1x9gknd 9711 32 was be VBD cord-010119-t1x9gknd 9711 33 HBV HBV NNP cord-010119-t1x9gknd 9711 34 genotype genotype NN cord-010119-t1x9gknd 9711 35 A. a. NN cord-010119-t1x9gknd 9711 36 Surveillance surveillance NN cord-010119-t1x9gknd 9711 37 over over IN cord-010119-t1x9gknd 9711 38 a a DT cord-010119-t1x9gknd 9711 39 longer long JJR cord-010119-t1x9gknd 9711 40 period period NN cord-010119-t1x9gknd 9712 1 is be VBZ cord-010119-t1x9gknd 9712 2 Background Background NNP cord-010119-t1x9gknd 9712 3 / / SYM cord-010119-t1x9gknd 9712 4 Case Case NNP cord-010119-t1x9gknd 9712 5 Studies Studies NNPS cord-010119-t1x9gknd 9712 6 : : : cord-010119-t1x9gknd 9713 1 The the DT cord-010119-t1x9gknd 9713 2 BacT BacT NNP cord-010119-t1x9gknd 9713 3 / / SYM cord-010119-t1x9gknd 9713 4 ALERT ALERT NNP cord-010119-t1x9gknd 9713 5 3D 3D NNP cord-010119-t1x9gknd 9713 6 Microbial Microbial NNP cord-010119-t1x9gknd 9713 7 Detection Detection NNP cord-010119-t1x9gknd 9713 8 System System NNP cord-010119-t1x9gknd 9713 9 ( ( -LRB- cord-010119-t1x9gknd 9713 10 BTA BTA NNP cord-010119-t1x9gknd 9713 11 3D 3D NNP cord-010119-t1x9gknd 9713 12 ) ) -RRB- cord-010119-t1x9gknd 9713 13 is be VBZ cord-010119-t1x9gknd 9713 14 currently currently RB cord-010119-t1x9gknd 9713 15 FDA FDA NNP cord-010119-t1x9gknd 9713 16 cleared clear VBN cord-010119-t1x9gknd 9713 17 for for IN cord-010119-t1x9gknd 9713 18 the the DT cord-010119-t1x9gknd 9713 19 quality quality NN cord-010119-t1x9gknd 9713 20 control control NN cord-010119-t1x9gknd 9713 21 testing testing NN cord-010119-t1x9gknd 9713 22 of of IN cord-010119-t1x9gknd 9713 23 Leukocyte Leukocyte NNP cord-010119-t1x9gknd 9713 24 Reduced Reduced NNP cord-010119-t1x9gknd 9713 25 Apheresis Apheresis NNP cord-010119-t1x9gknd 9713 26 Platelets platelet NNS cord-010119-t1x9gknd 9713 27 ( ( -LRB- cord-010119-t1x9gknd 9713 28 LRAPs lrap NNS cord-010119-t1x9gknd 9713 29 ) ) -RRB- cord-010119-t1x9gknd 9713 30 . . . cord-010119-t1x9gknd 9714 1 The the DT cord-010119-t1x9gknd 9714 2 BacT BacT NNP cord-010119-t1x9gknd 9714 3 / / SYM cord-010119-t1x9gknd 9714 4 ALERT alert NN cord-010119-t1x9gknd 9714 5 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9714 6 Microbial Microbial NNP cord-010119-t1x9gknd 9714 7 Detection Detection NNP cord-010119-t1x9gknd 9714 8 System System NNP cord-010119-t1x9gknd 9714 9 ( ( -LRB- cord-010119-t1x9gknd 9714 10 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9714 11 ) ) -RRB- cord-010119-t1x9gknd 9715 1 ( ( -LRB- cord-010119-t1x9gknd 9715 2 bioM biom JJ cord-010119-t1x9gknd 9715 3 erieux erieux NNP cord-010119-t1x9gknd 9715 4 , , , cord-010119-t1x9gknd 9715 5 St. St. NNP cord-010119-t1x9gknd 9715 6 Louis Louis NNP cord-010119-t1x9gknd 9715 7 , , , cord-010119-t1x9gknd 9715 8 MO MO NNP cord-010119-t1x9gknd 9715 9 ) ) -RRB- cord-010119-t1x9gknd 9715 10 is be VBZ cord-010119-t1x9gknd 9715 11 a a DT cord-010119-t1x9gknd 9715 12 new new JJ cord-010119-t1x9gknd 9715 13 generation generation NN cord-010119-t1x9gknd 9715 14 of of IN cord-010119-t1x9gknd 9715 15 BacT BacT NNP cord-010119-t1x9gknd 9715 16 / / SYM cord-010119-t1x9gknd 9715 17 ALERT alert NN cord-010119-t1x9gknd 9715 18 instrumentation instrumentation NN cord-010119-t1x9gknd 9715 19 . . . cord-010119-t1x9gknd 9716 1 The the DT cord-010119-t1x9gknd 9716 2 underlying underlying JJ cord-010119-t1x9gknd 9716 3 colorimetric colorimetric JJ cord-010119-t1x9gknd 9716 4 technology technology NN cord-010119-t1x9gknd 9716 5 used use VBN cord-010119-t1x9gknd 9716 6 in in IN cord-010119-t1x9gknd 9716 7 previous previous JJ cord-010119-t1x9gknd 9716 8 generations generation NNS cord-010119-t1x9gknd 9716 9 of of IN cord-010119-t1x9gknd 9716 10 BacT BacT NNP cord-010119-t1x9gknd 9716 11 / / SYM cord-010119-t1x9gknd 9716 12 ALERT ALERT NNP cord-010119-t1x9gknd 9716 13 is be VBZ cord-010119-t1x9gknd 9716 14 used use VBN cord-010119-t1x9gknd 9716 15 in in IN cord-010119-t1x9gknd 9716 16 the the DT cord-010119-t1x9gknd 9716 17 VIR VIR NNP cord-010119-t1x9gknd 9716 18 - - HYPH cord-010119-t1x9gknd 9716 19 TUO TUO NNP cord-010119-t1x9gknd 9716 20 and and CC cord-010119-t1x9gknd 9716 21 incorporates incorporate VBZ cord-010119-t1x9gknd 9716 22 new new JJ cord-010119-t1x9gknd 9716 23 instrument instrument NN cord-010119-t1x9gknd 9716 24 architecture architecture NN cord-010119-t1x9gknd 9716 25 to to TO cord-010119-t1x9gknd 9716 26 improve improve VB cord-010119-t1x9gknd 9716 27 temperature temperature NN cord-010119-t1x9gknd 9716 28 stability stability NN cord-010119-t1x9gknd 9716 29 , , , cord-010119-t1x9gknd 9716 30 workflow workflow NN cord-010119-t1x9gknd 9716 31 improvement improvement NN cord-010119-t1x9gknd 9716 32 via via IN cord-010119-t1x9gknd 9716 33 automation automation NN cord-010119-t1x9gknd 9716 34 of of IN cord-010119-t1x9gknd 9716 35 processes process NNS cord-010119-t1x9gknd 9716 36 that that WDT cord-010119-t1x9gknd 9716 37 are be VBP cord-010119-t1x9gknd 9716 38 currently currently RB cord-010119-t1x9gknd 9716 39 performed perform VBN cord-010119-t1x9gknd 9716 40 manually manually RB cord-010119-t1x9gknd 9716 41 , , , cord-010119-t1x9gknd 9716 42 an an DT cord-010119-t1x9gknd 9716 43 improved improved JJ cord-010119-t1x9gknd 9716 44 user user NN cord-010119-t1x9gknd 9716 45 interface interface NN cord-010119-t1x9gknd 9716 46 and and CC cord-010119-t1x9gknd 9716 47 an an DT cord-010119-t1x9gknd 9716 48 enhanced enhanced JJ cord-010119-t1x9gknd 9716 49 algorithm algorithm NN cord-010119-t1x9gknd 9716 50 to to TO cord-010119-t1x9gknd 9716 51 shorten shorten VB cord-010119-t1x9gknd 9716 52 time time NN cord-010119-t1x9gknd 9716 53 to to IN cord-010119-t1x9gknd 9716 54 detection detection NN cord-010119-t1x9gknd 9716 55 . . . cord-010119-t1x9gknd 9717 1 The the DT cord-010119-t1x9gknd 9717 2 objective objective NN cord-010119-t1x9gknd 9717 3 of of IN cord-010119-t1x9gknd 9717 4 this this DT cord-010119-t1x9gknd 9717 5 study study NN cord-010119-t1x9gknd 9717 6 was be VBD cord-010119-t1x9gknd 9717 7 to to TO cord-010119-t1x9gknd 9717 8 compare compare VB cord-010119-t1x9gknd 9717 9 the the DT cord-010119-t1x9gknd 9717 10 performance performance NN cord-010119-t1x9gknd 9717 11 of of IN cord-010119-t1x9gknd 9717 12 the the DT cord-010119-t1x9gknd 9717 13 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 9717 14 and and CC cord-010119-t1x9gknd 9717 15 BacT BacT NNP cord-010119-t1x9gknd 9717 16 / / SYM cord-010119-t1x9gknd 9717 17 ALERT ALERT NNP cord-010119-t1x9gknd 9717 18 3D 3D NNP cord-010119-t1x9gknd 9717 19 ( ( -LRB- cord-010119-t1x9gknd 9717 20 BTA BTA NNP cord-010119-t1x9gknd 9717 21 3D 3D NNP cord-010119-t1x9gknd 9717 22 ) ) -RRB- cord-010119-t1x9gknd 9717 23 instruments instrument NNS cord-010119-t1x9gknd 9717 24 , , , cord-010119-t1x9gknd 9717 25 using use VBG cord-010119-t1x9gknd 9717 26 BacT BacT NNP cord-010119-t1x9gknd 9717 27 / / SYM cord-010119-t1x9gknd 9717 28 ALERT ALERT NNP cord-010119-t1x9gknd 9717 29 BPA BPA NNP cord-010119-t1x9gknd 9717 30 ( ( -LRB- cord-010119-t1x9gknd 9717 31 aerobic aerobic NN cord-010119-t1x9gknd 9717 32 ) ) -RRB- cord-010119-t1x9gknd 9717 33 and and CC cord-010119-t1x9gknd 9717 34 BacT BacT NNP cord-010119-t1x9gknd 9717 35 / / SYM cord-010119-t1x9gknd 9717 36 ALERT ALERT NNP cord-010119-t1x9gknd 9717 37 BPN BPN NNP cord-010119-t1x9gknd 9717 38 ( ( -LRB- cord-010119-t1x9gknd 9717 39 anaerobic anaerobic JJ cord-010119-t1x9gknd 9717 40 ) ) -RRB- cord-010119-t1x9gknd 9717 41 bottles bottle NNS cord-010119-t1x9gknd 9717 42 , , , cord-010119-t1x9gknd 9717 43 for for IN cord-010119-t1x9gknd 9717 44 the the DT cord-010119-t1x9gknd 9717 45 detection detection NN cord-010119-t1x9gknd 9717 46 of of IN cord-010119-t1x9gknd 9717 47 a a DT cord-010119-t1x9gknd 9717 48 range range NN cord-010119-t1x9gknd 9717 49 of of IN cord-010119-t1x9gknd 9717 50 typical typical JJ cord-010119-t1x9gknd 9717 51 bacterial bacterial JJ cord-010119-t1x9gknd 9717 52 contaminants contaminant NNS cord-010119-t1x9gknd 9717 53 seeded seed VBN cord-010119-t1x9gknd 9717 54 into into IN cord-010119-t1x9gknd 9717 55 leukocyte leukocyte NN cord-010119-t1x9gknd 9717 56 reduced reduce VBN cord-010119-t1x9gknd 9717 57 apheresis apheresis NN cord-010119-t1x9gknd 9717 58 platelets platelet NNS cord-010119-t1x9gknd 9717 59 ( ( -LRB- cord-010119-t1x9gknd 9717 60 LRAPs LRAPs NNP cord-010119-t1x9gknd 9717 61 ) ) -RRB- cord-010119-t1x9gknd 9717 62 . . . cord-010119-t1x9gknd 9718 1 * * NFP cord-010119-t1x9gknd 9718 2 Study Study NNP cord-010119-t1x9gknd 9718 3 Design Design NNP cord-010119-t1x9gknd 9718 4 / / SYM cord-010119-t1x9gknd 9718 5 Method method NN cord-010119-t1x9gknd 9718 6 : : : cord-010119-t1x9gknd 9718 7 The the DT cord-010119-t1x9gknd 9718 8 study study NN cord-010119-t1x9gknd 9718 9 was be VBD cord-010119-t1x9gknd 9718 10 performed perform VBN cord-010119-t1x9gknd 9718 11 at at IN cord-010119-t1x9gknd 9718 12 two two CD cord-010119-t1x9gknd 9718 13 institutions institution NNS cord-010119-t1x9gknd 9718 14 , , , cord-010119-t1x9gknd 9718 15 one one CD cord-010119-t1x9gknd 9718 16 in in IN cord-010119-t1x9gknd 9718 17 the the DT cord-010119-t1x9gknd 9718 18 US US NNP cord-010119-t1x9gknd 9718 19 and and CC cord-010119-t1x9gknd 9718 20 the the DT cord-010119-t1x9gknd 9718 21 other other JJ cord-010119-t1x9gknd 9718 22 in in IN cord-010119-t1x9gknd 9718 23 the the DT cord-010119-t1x9gknd 9718 24 UK UK NNP cord-010119-t1x9gknd 9718 25 . . . cord-010119-t1x9gknd 9719 1 Aliquots Aliquots NNP cord-010119-t1x9gknd 9719 2 of of IN cord-010119-t1x9gknd 9719 3 LRAPs lrap NNS cord-010119-t1x9gknd 9719 4 were be VBD cord-010119-t1x9gknd 9719 5 seeded seed VBN cord-010119-t1x9gknd 9719 6 with with IN cord-010119-t1x9gknd 9719 7 low low JJ cord-010119-t1x9gknd 9719 8 levels level NNS cord-010119-t1x9gknd 9719 9 ( ( -LRB- cord-010119-t1x9gknd 9719 10 1 1 CD cord-010119-t1x9gknd 9719 11 - - SYM cord-010119-t1x9gknd 9719 12 20 20 CD cord-010119-t1x9gknd 9719 13 cfu cfu NN cord-010119-t1x9gknd 9719 14 / / SYM cord-010119-t1x9gknd 9719 15 mL mL NNP cord-010119-t1x9gknd 9719 16 ) ) -RRB- cord-010119-t1x9gknd 9719 17 of of IN cord-010119-t1x9gknd 9719 18 11 11 CD cord-010119-t1x9gknd 9719 19 bacterial bacterial JJ cord-010119-t1x9gknd 9719 20 species specie NNS cord-010119-t1x9gknd 9719 21 commonly commonly RB cord-010119-t1x9gknd 9719 22 associated associate VBN cord-010119-t1x9gknd 9719 23 with with IN cord-010119-t1x9gknd 9719 24 platelet platelet NN cord-010119-t1x9gknd 9719 25 contamination contamination NN cord-010119-t1x9gknd 9719 26 , , , cord-010119-t1x9gknd 9719 27 and and CC cord-010119-t1x9gknd 9719 28 20 20 CD cord-010119-t1x9gknd 9719 29 replicates replicate NNS cord-010119-t1x9gknd 9719 30 ( ( -LRB- cord-010119-t1x9gknd 9719 31 10 10 CD cord-010119-t1x9gknd 9719 32 per per IN cord-010119-t1x9gknd 9719 33 instrument instrument NN cord-010119-t1x9gknd 9719 34 ) ) -RRB- cord-010119-t1x9gknd 9719 35 of of IN cord-010119-t1x9gknd 9719 36 4 4 CD cord-010119-t1x9gknd 9719 37 mL ml NN cord-010119-t1x9gknd 9719 38 aliquots aliquot NNS cord-010119-t1x9gknd 9719 39 per per IN cord-010119-t1x9gknd 9719 40 bottle bottle NN cord-010119-t1x9gknd 9719 41 were be VBD cord-010119-t1x9gknd 9719 42 inoculated inoculate VBN cord-010119-t1x9gknd 9719 43 into into IN cord-010119-t1x9gknd 9719 44 BPA BPA NNP cord-010119-t1x9gknd 9719 45 and and CC cord-010119-t1x9gknd 9719 46 BPN BPN NNP cord-010119-t1x9gknd 9719 47 bottles bottle NNS cord-010119-t1x9gknd 9719 48 . . . cord-010119-t1x9gknd 9720 1 One one CD cord-010119-t1x9gknd 9720 2 set set NN cord-010119-t1x9gknd 9720 3 of of IN cord-010119-t1x9gknd 9720 4 bottles bottle NNS cord-010119-t1x9gknd 9720 5 was be VBD cord-010119-t1x9gknd 9720 6 loaded load VBN cord-010119-t1x9gknd 9720 7 into into IN cord-010119-t1x9gknd 9720 8 BTA BTA NNP cord-010119-t1x9gknd 9720 9 3D 3D NNP cord-010119-t1x9gknd 9720 10 and and CC cord-010119-t1x9gknd 9720 11 the the DT cord-010119-t1x9gknd 9720 12 other other JJ cord-010119-t1x9gknd 9720 13 into into IN cord-010119-t1x9gknd 9720 14 VIRTUO VIRTUO NNS cord-010119-t1x9gknd 9720 15 and and CC cord-010119-t1x9gknd 9720 16 incubated incubate VBN cord-010119-t1x9gknd 9720 17 until until IN cord-010119-t1x9gknd 9720 18 signaled signal VBN cord-010119-t1x9gknd 9720 19 positive positive JJ cord-010119-t1x9gknd 9720 20 by by IN cord-010119-t1x9gknd 9720 21 the the DT cord-010119-t1x9gknd 9720 22 instruments instrument NNS cord-010119-t1x9gknd 9720 23 or or CC cord-010119-t1x9gknd 9720 24 for for IN cord-010119-t1x9gknd 9720 25 up up IN cord-010119-t1x9gknd 9720 26 to to TO cord-010119-t1x9gknd 9720 27 7 7 CD cord-010119-t1x9gknd 9720 28 days day NNS cord-010119-t1x9gknd 9720 29 . . . cord-010119-t1x9gknd 9721 1 Overall overall JJ cord-010119-t1x9gknd 9721 2 detection detection NN cord-010119-t1x9gknd 9721 3 rates rate NNS cord-010119-t1x9gknd 9721 4 and and CC cord-010119-t1x9gknd 9721 5 time time NN cord-010119-t1x9gknd 9721 6 to to IN cord-010119-t1x9gknd 9721 7 detection detection NN cord-010119-t1x9gknd 9721 8 of of IN cord-010119-t1x9gknd 9721 9 bacterial bacterial JJ cord-010119-t1x9gknd 9721 10 contaminants contaminant NNS cord-010119-t1x9gknd 9721 11 between between IN cord-010119-t1x9gknd 9721 12 instruments instrument NNS cord-010119-t1x9gknd 9721 13 were be VBD cord-010119-t1x9gknd 9721 14 compared compare VBN cord-010119-t1x9gknd 9721 15 . . . cord-010119-t1x9gknd 9722 1 Additionally additionally RB cord-010119-t1x9gknd 9722 2 98 98 CD cord-010119-t1x9gknd 9722 3 bottles bottle NNS cord-010119-t1x9gknd 9722 4 were be VBD cord-010119-t1x9gknd 9722 5 tested test VBN cord-010119-t1x9gknd 9722 6 in in IN cord-010119-t1x9gknd 9722 7 each each DT cord-010119-t1x9gknd 9722 8 instrument instrument NN cord-010119-t1x9gknd 9722 9 ( ( -LRB- cord-010119-t1x9gknd 9722 10 LRAPs LRAPs NNP cord-010119-t1x9gknd 9722 11 only only RB cord-010119-t1x9gknd 9722 12 , , , cord-010119-t1x9gknd 9722 13 no no DT cord-010119-t1x9gknd 9722 14 organism organism NN cord-010119-t1x9gknd 9722 15 ) ) -RRB- cord-010119-t1x9gknd 9722 16 to to TO cord-010119-t1x9gknd 9722 17 evaluate evaluate VB cord-010119-t1x9gknd 9722 18 differences difference NNS cord-010119-t1x9gknd 9722 19 in in IN cord-010119-t1x9gknd 9722 20 the the DT cord-010119-t1x9gknd 9722 21 overall overall JJ cord-010119-t1x9gknd 9722 22 negative negative JJ cord-010119-t1x9gknd 9722 23 agreement agreement NN cord-010119-t1x9gknd 9722 24 rates rate NNS cord-010119-t1x9gknd 9722 25 ( ( -LRB- cord-010119-t1x9gknd 9722 26 detection detection NN cord-010119-t1x9gknd 9722 27 of of IN cord-010119-t1x9gknd 9722 28 false false JJ cord-010119-t1x9gknd 9722 29 positives positive NNS cord-010119-t1x9gknd 9722 30 ) ) -RRB- cord-010119-t1x9gknd 9722 31 between between IN cord-010119-t1x9gknd 9722 32 instruments instrument NNS cord-010119-t1x9gknd 9722 33 and and CC cord-010119-t1x9gknd 9722 34 to to TO cord-010119-t1x9gknd 9722 35 serve serve VB cord-010119-t1x9gknd 9722 36 as as IN cord-010119-t1x9gknd 9722 37 sterility sterility NN cord-010119-t1x9gknd 9722 38 controls control NNS cord-010119-t1x9gknd 9722 39 for for IN cord-010119-t1x9gknd 9722 40 the the DT cord-010119-t1x9gknd 9722 41 platelet platelet NN cord-010119-t1x9gknd 9722 42 preparations preparation NNS cord-010119-t1x9gknd 9722 43 . . . cord-010119-t1x9gknd 9723 1 Background Background NNP cord-010119-t1x9gknd 9723 2 / / SYM cord-010119-t1x9gknd 9723 3 Case Case NNP cord-010119-t1x9gknd 9723 4 Studies Studies NNPS cord-010119-t1x9gknd 9723 5 : : : cord-010119-t1x9gknd 9724 1 The the DT cord-010119-t1x9gknd 9724 2 implementation implementation NN cord-010119-t1x9gknd 9724 3 of of IN cord-010119-t1x9gknd 9724 4 Nucleic Nucleic NNP cord-010119-t1x9gknd 9724 5 Acid acid NN cord-010119-t1x9gknd 9724 6 Testing Testing NNP cord-010119-t1x9gknd 9724 7 ( ( -LRB- cord-010119-t1x9gknd 9724 8 NAT NAT NNP cord-010119-t1x9gknd 9724 9 ) ) -RRB- cord-010119-t1x9gknd 9724 10 blood blood NN cord-010119-t1x9gknd 9724 11 screening screening NN cord-010119-t1x9gknd 9724 12 is be VBZ cord-010119-t1x9gknd 9724 13 still still RB cord-010119-t1x9gknd 9724 14 a a DT cord-010119-t1x9gknd 9724 15 challenge challenge NN cord-010119-t1x9gknd 9724 16 in in IN cord-010119-t1x9gknd 9724 17 resource resource NN cord-010119-t1x9gknd 9724 18 - - HYPH cord-010119-t1x9gknd 9724 19 limited limit VBN cord-010119-t1x9gknd 9724 20 countries country NNS cord-010119-t1x9gknd 9724 21 . . . cord-010119-t1x9gknd 9725 1 At at IN cord-010119-t1x9gknd 9725 2 the the DT cord-010119-t1x9gknd 9725 3 same same JJ cord-010119-t1x9gknd 9725 4 time time NN cord-010119-t1x9gknd 9725 5 , , , cord-010119-t1x9gknd 9725 6 in in IN cord-010119-t1x9gknd 9725 7 these these DT cord-010119-t1x9gknd 9725 8 countries country NNS cord-010119-t1x9gknd 9725 9 , , , cord-010119-t1x9gknd 9725 10 higher high JJR cord-010119-t1x9gknd 9725 11 to to IN cord-010119-t1x9gknd 9725 12 similar similar JJ cord-010119-t1x9gknd 9725 13 proportions proportion NNS cord-010119-t1x9gknd 9725 14 of of IN cord-010119-t1x9gknd 9725 15 replacement replacement NN cord-010119-t1x9gknd 9725 16 to to IN cord-010119-t1x9gknd 9725 17 voluntary voluntary JJ cord-010119-t1x9gknd 9725 18 blood blood NN cord-010119-t1x9gknd 9725 19 donors donor NNS cord-010119-t1x9gknd 9725 20 are be VBP cord-010119-t1x9gknd 9725 21 recruited recruit VBN cord-010119-t1x9gknd 9725 22 . . . cord-010119-t1x9gknd 9726 1 A a DT cord-010119-t1x9gknd 9726 2 higher high JJR cord-010119-t1x9gknd 9726 3 prevalence prevalence NN cord-010119-t1x9gknd 9726 4 of of IN cord-010119-t1x9gknd 9726 5 infections infection NNS cord-010119-t1x9gknd 9726 6 is be VBZ cord-010119-t1x9gknd 9726 7 observed observe VBN cord-010119-t1x9gknd 9726 8 in in IN cord-010119-t1x9gknd 9726 9 relation relation NN cord-010119-t1x9gknd 9726 10 to to IN cord-010119-t1x9gknd 9726 11 developed develop VBN cord-010119-t1x9gknd 9726 12 countries country NNS cord-010119-t1x9gknd 9726 13 . . . cord-010119-t1x9gknd 9727 1 As as IN cord-010119-t1x9gknd 9727 2 a a DT cord-010119-t1x9gknd 9727 3 consequence consequence NN cord-010119-t1x9gknd 9727 4 , , , cord-010119-t1x9gknd 9727 5 more more JJR cord-010119-t1x9gknd 9727 6 incident incident NN cord-010119-t1x9gknd 9727 7 cases case NNS cord-010119-t1x9gknd 9727 8 of of IN cord-010119-t1x9gknd 9727 9 infections infection NNS cord-010119-t1x9gknd 9727 10 can can MD cord-010119-t1x9gknd 9727 11 be be VB cord-010119-t1x9gknd 9727 12 expected expect VBN cord-010119-t1x9gknd 9727 13 . . . cord-010119-t1x9gknd 9728 1 In in IN cord-010119-t1x9gknd 9728 2 our -PRON- PRP$ cord-010119-t1x9gknd 9728 3 country country NN cord-010119-t1x9gknd 9728 4 , , , cord-010119-t1x9gknd 9728 5 some some DT cord-010119-t1x9gknd 9728 6 hospital hospital NN cord-010119-t1x9gknd 9728 7 blood blood NN cord-010119-t1x9gknd 9728 8 banks bank NNS cord-010119-t1x9gknd 9728 9 could could MD cord-010119-t1x9gknd 9728 10 not not RB cord-010119-t1x9gknd 9728 11 afford afford VB cord-010119-t1x9gknd 9728 12 NAT NAT NNP cord-010119-t1x9gknd 9728 13 due due JJ cord-010119-t1x9gknd 9728 14 to to IN cord-010119-t1x9gknd 9728 15 high high JJ cord-010119-t1x9gknd 9728 16 costs cost NNS cord-010119-t1x9gknd 9728 17 , , , cord-010119-t1x9gknd 9728 18 but but CC cord-010119-t1x9gknd 9728 19 belong belong VBP cord-010119-t1x9gknd 9728 20 to to IN cord-010119-t1x9gknd 9728 21 a a DT cord-010119-t1x9gknd 9728 22 net net NN cord-010119-t1x9gknd 9728 23 that that WDT cord-010119-t1x9gknd 9728 24 centralizes centralize VBZ cord-010119-t1x9gknd 9728 25 NAT NAT NNP cord-010119-t1x9gknd 9728 26 in in IN cord-010119-t1x9gknd 9728 27 a a DT cord-010119-t1x9gknd 9728 28 reference reference NN cord-010119-t1x9gknd 9728 29 Blood Blood NNP cord-010119-t1x9gknd 9728 30 Center Center NNP cord-010119-t1x9gknd 9728 31 . . . cord-010119-t1x9gknd 9729 1 The the DT cord-010119-t1x9gknd 9729 2 process process NN cord-010119-t1x9gknd 9729 3 to to TO cord-010119-t1x9gknd 9729 4 consolidate consolidate VB cord-010119-t1x9gknd 9729 5 small small JJ cord-010119-t1x9gknd 9729 6 blood blood NN cord-010119-t1x9gknd 9729 7 banks bank NNS cord-010119-t1x9gknd 9729 8 in in IN cord-010119-t1x9gknd 9729 9 Regional Regional NNP cord-010119-t1x9gknd 9729 10 Blood Blood NNP cord-010119-t1x9gknd 9729 11 Centers Centers NNPS cord-010119-t1x9gknd 9729 12 , , , cord-010119-t1x9gknd 9729 13 which which WDT cord-010119-t1x9gknd 9729 14 will will MD cord-010119-t1x9gknd 9729 15 be be VB cord-010119-t1x9gknd 9729 16 able able JJ cord-010119-t1x9gknd 9729 17 to to TO cord-010119-t1x9gknd 9729 18 implement implement VB cord-010119-t1x9gknd 9729 19 NAT NAT NNP cord-010119-t1x9gknd 9729 20 , , , cord-010119-t1x9gknd 9729 21 is be VBZ cord-010119-t1x9gknd 9729 22 not not RB cord-010119-t1x9gknd 9729 23 yet yet RB cord-010119-t1x9gknd 9729 24 complete complete JJ cord-010119-t1x9gknd 9729 25 . . . cord-010119-t1x9gknd 9730 1 Although although IN cord-010119-t1x9gknd 9730 2 efforts effort NNS cord-010119-t1x9gknd 9730 3 to to TO cord-010119-t1x9gknd 9730 4 reduce reduce VB cord-010119-t1x9gknd 9730 5 replacement replacement NN cord-010119-t1x9gknd 9730 6 /familiar /familiar . cord-010119-t1x9gknd 9730 7 blood blood NN cord-010119-t1x9gknd 9730 8 donations donation NNS cord-010119-t1x9gknd 9730 9 are be VBP cord-010119-t1x9gknd 9730 10 in in IN cord-010119-t1x9gknd 9730 11 progress progress NN cord-010119-t1x9gknd 9730 12 , , , cord-010119-t1x9gknd 9730 13 these these DT cord-010119-t1x9gknd 9730 14 goals goal NNS cord-010119-t1x9gknd 9730 15 have have VBP cord-010119-t1x9gknd 9730 16 not not RB cord-010119-t1x9gknd 9730 17 been be VBN cord-010119-t1x9gknd 9730 18 completely completely RB cord-010119-t1x9gknd 9730 19 achieved achieve VBN cord-010119-t1x9gknd 9730 20 . . . cord-010119-t1x9gknd 9731 1 The the DT cord-010119-t1x9gknd 9731 2 aims aim NNS cord-010119-t1x9gknd 9731 3 were be VBD cord-010119-t1x9gknd 9731 4 to to TO cord-010119-t1x9gknd 9731 5 compare compare VB cord-010119-t1x9gknd 9731 6 the the DT cord-010119-t1x9gknd 9731 7 prevalence prevalence NN cord-010119-t1x9gknd 9731 8 of of IN cord-010119-t1x9gknd 9731 9 HIV HIV NNP cord-010119-t1x9gknd 9731 10 , , , cord-010119-t1x9gknd 9731 11 HCV HCV NNP cord-010119-t1x9gknd 9731 12 and and CC cord-010119-t1x9gknd 9731 13 HBV HBV NNP cord-010119-t1x9gknd 9731 14 by by IN cord-010119-t1x9gknd 9731 15 NAT NAT NNP cord-010119-t1x9gknd 9731 16 screening screening NN cord-010119-t1x9gknd 9731 17 in in IN cord-010119-t1x9gknd 9731 18 a a DT cord-010119-t1x9gknd 9731 19 blood blood NN cord-010119-t1x9gknd 9731 20 center center NN cord-010119-t1x9gknd 9731 21 recruiting recruit VBG cord-010119-t1x9gknd 9731 22 only only RB cord-010119-t1x9gknd 9731 23 voluntary voluntary JJ cord-010119-t1x9gknd 9731 24 blood blood NN cord-010119-t1x9gknd 9731 25 donors donor NNS cord-010119-t1x9gknd 9731 26 with with IN cord-010119-t1x9gknd 9731 27 the the DT cord-010119-t1x9gknd 9731 28 prevalence prevalence NN cord-010119-t1x9gknd 9731 29 in in IN cord-010119-t1x9gknd 9731 30 centers center NNS cord-010119-t1x9gknd 9731 31 recruiting recruit VBG cord-010119-t1x9gknd 9731 32 replacement replacement NN cord-010119-t1x9gknd 9731 33 and and CC cord-010119-t1x9gknd 9731 34 voluntary voluntary JJ cord-010119-t1x9gknd 9731 35 blood blood NN cord-010119-t1x9gknd 9731 36 donors donor NNS cord-010119-t1x9gknd 9731 37 , , , cord-010119-t1x9gknd 9731 38 and and CC cord-010119-t1x9gknd 9731 39 describe describe VB cord-010119-t1x9gknd 9731 40 the the DT cord-010119-t1x9gknd 9731 41 NAT NAT NNP cord-010119-t1x9gknd 9731 42 yield yield NN cord-010119-t1x9gknd 9731 43 rates rate NNS cord-010119-t1x9gknd 9731 44 for for IN cord-010119-t1x9gknd 9731 45 HIV HIV NNP cord-010119-t1x9gknd 9731 46 , , , cord-010119-t1x9gknd 9731 47 HCV HCV NNP cord-010119-t1x9gknd 9731 48 and and CC cord-010119-t1x9gknd 9731 49 HBV HBV NNP cord-010119-t1x9gknd 9731 50 in in IN cord-010119-t1x9gknd 9731 51 a a DT cord-010119-t1x9gknd 9731 52 period period NN cord-010119-t1x9gknd 9731 53 of of IN cord-010119-t1x9gknd 9731 54 three three CD cord-010119-t1x9gknd 9731 55 and and CC cord-010119-t1x9gknd 9731 56 a a DT cord-010119-t1x9gknd 9731 57 half half JJ cord-010119-t1x9gknd 9731 58 year year NN cord-010119-t1x9gknd 9731 59 experience experience NN cord-010119-t1x9gknd 9731 60 . . . cord-010119-t1x9gknd 9732 1 Study Study NNP cord-010119-t1x9gknd 9732 2 Design Design NNP cord-010119-t1x9gknd 9732 3 / / SYM cord-010119-t1x9gknd 9732 4 Method method NN cord-010119-t1x9gknd 9732 5 : : : cord-010119-t1x9gknd 9733 1 A a DT cord-010119-t1x9gknd 9733 2 Regional Regional NNP cord-010119-t1x9gknd 9733 3 Blood Blood NNP cord-010119-t1x9gknd 9733 4 Donor Donor NNP cord-010119-t1x9gknd 9733 5 Center Center NNP cord-010119-t1x9gknd 9733 6 ( ( -LRB- cord-010119-t1x9gknd 9733 7 RBDC RBDC NNP cord-010119-t1x9gknd 9733 8 ) ) -RRB- cord-010119-t1x9gknd 9733 9 has have VBZ cord-010119-t1x9gknd 9733 10 centralized centralize VBN cord-010119-t1x9gknd 9733 11 NAT NAT NNP cord-010119-t1x9gknd 9733 12 screening screening NN cord-010119-t1x9gknd 9733 13 from from IN cord-010119-t1x9gknd 9733 14 centers center NNS cord-010119-t1x9gknd 9733 15 in in IN cord-010119-t1x9gknd 9733 16 different different JJ cord-010119-t1x9gknd 9733 17 regions region NNS cord-010119-t1x9gknd 9733 18 of of IN cord-010119-t1x9gknd 9733 19 the the DT cord-010119-t1x9gknd 9733 20 country country NN cord-010119-t1x9gknd 9733 21 due due JJ cord-010119-t1x9gknd 9733 22 to to IN cord-010119-t1x9gknd 9733 23 since since IN cord-010119-t1x9gknd 9733 24 August August NNP cord-010119-t1x9gknd 9733 25 2013 2013 CD cord-010119-t1x9gknd 9733 26 . . . cord-010119-t1x9gknd 9734 1 This this DT cord-010119-t1x9gknd 9734 2 process process NN cord-010119-t1x9gknd 9734 3 required require VBN cord-010119-t1x9gknd 9734 4 to to TO cord-010119-t1x9gknd 9734 5 achieve achieve VB cord-010119-t1x9gknd 9734 6 adequate adequate JJ cord-010119-t1x9gknd 9734 7 laboratory laboratory NN cord-010119-t1x9gknd 9734 8 conditions condition NNS cord-010119-t1x9gknd 9734 9 and and CC cord-010119-t1x9gknd 9734 10 staff staff NN cord-010119-t1x9gknd 9734 11 qualification qualification NN cord-010119-t1x9gknd 9734 12 and and CC cord-010119-t1x9gknd 9734 13 a a DT cord-010119-t1x9gknd 9734 14 development development NN cord-010119-t1x9gknd 9734 15 of of IN cord-010119-t1x9gknd 9734 16 software software NN cord-010119-t1x9gknd 9734 17 to to TO cord-010119-t1x9gknd 9734 18 assure assure VB cord-010119-t1x9gknd 9734 19 sample sample NN cord-010119-t1x9gknd 9734 20 traceability traceability NN cord-010119-t1x9gknd 9734 21 and and CC cord-010119-t1x9gknd 9734 22 interface interface NN cord-010119-t1x9gknd 9734 23 for for IN cord-010119-t1x9gknd 9734 24 transmission transmission NN cord-010119-t1x9gknd 9734 25 of of IN cord-010119-t1x9gknd 9734 26 results result NNS cord-010119-t1x9gknd 9734 27 . . . cord-010119-t1x9gknd 9735 1 When when WRB cord-010119-t1x9gknd 9735 2 a a DT cord-010119-t1x9gknd 9735 3 window window NN cord-010119-t1x9gknd 9735 4 period period NN cord-010119-t1x9gknd 9735 5 was be VBD cord-010119-t1x9gknd 9735 6 suspected suspect VBN cord-010119-t1x9gknd 9735 7 , , , cord-010119-t1x9gknd 9735 8 the the DT cord-010119-t1x9gknd 9735 9 NAT NAT NNP cord-010119-t1x9gknd 9735 10 screening screening NN cord-010119-t1x9gknd 9735 11 was be VBD cord-010119-t1x9gknd 9735 12 repeated repeat VBN cord-010119-t1x9gknd 9735 13 from from IN cord-010119-t1x9gknd 9735 14 the the DT cord-010119-t1x9gknd 9735 15 plasma plasma NN cord-010119-t1x9gknd 9735 16 unit unit NN cord-010119-t1x9gknd 9735 17 and and CC cord-010119-t1x9gknd 9735 18 a a DT cord-010119-t1x9gknd 9735 19 second second JJ cord-010119-t1x9gknd 9735 20 sample sample NN cord-010119-t1x9gknd 9735 21 of of IN cord-010119-t1x9gknd 9735 22 the the DT cord-010119-t1x9gknd 9735 23 blood blood NN cord-010119-t1x9gknd 9735 24 donor donor NN cord-010119-t1x9gknd 9735 25 was be VBD cord-010119-t1x9gknd 9735 26 required require VBN cord-010119-t1x9gknd 9735 27 to to TO cord-010119-t1x9gknd 9735 28 confirm confirm VB cord-010119-t1x9gknd 9735 29 NAT NAT NNP cord-010119-t1x9gknd 9735 30 results result NNS cord-010119-t1x9gknd 9735 31 . . . cord-010119-t1x9gknd 9736 1 This this DT cord-010119-t1x9gknd 9736 2 RBDC RBDC NNP cord-010119-t1x9gknd 9736 3 have have VBP cord-010119-t1x9gknd 9736 4 also also RB cord-010119-t1x9gknd 9736 5 been be VBN cord-010119-t1x9gknd 9736 6 developed develop VBN cord-010119-t1x9gknd 9736 7 a a DT cord-010119-t1x9gknd 9736 8 100 100 CD cord-010119-t1x9gknd 9736 9 % % NN cord-010119-t1x9gknd 9736 10 Voluntary Voluntary NNP cord-010119-t1x9gknd 9736 11 Donor Donor NNP cord-010119-t1x9gknd 9736 12 Program Program NNP cord-010119-t1x9gknd 9736 13 since since IN cord-010119-t1x9gknd 9736 14 2011 2011 CD cord-010119-t1x9gknd 9736 15 and and CC cord-010119-t1x9gknd 9736 16 is be VBZ cord-010119-t1x9gknd 9736 17 the the DT cord-010119-t1x9gknd 9736 18 only only JJ cord-010119-t1x9gknd 9736 19 center center NN cord-010119-t1x9gknd 9736 20 in in IN cord-010119-t1x9gknd 9736 21 the the DT cord-010119-t1x9gknd 9736 22 country country NN cord-010119-t1x9gknd 9736 23 that that WDT cord-010119-t1x9gknd 9736 24 has have VBZ cord-010119-t1x9gknd 9736 25 achieved achieve VBN cord-010119-t1x9gknd 9736 26 this this DT cord-010119-t1x9gknd 9736 27 goal goal NN cord-010119-t1x9gknd 9736 28 . . . cord-010119-t1x9gknd 9737 1 Results result NNS cord-010119-t1x9gknd 9737 2 / / SYM cord-010119-t1x9gknd 9737 3 Findings finding NNS cord-010119-t1x9gknd 9737 4 : : : cord-010119-t1x9gknd 9738 1 A a DT cord-010119-t1x9gknd 9738 2 total total NN cord-010119-t1x9gknd 9738 3 of of IN cord-010119-t1x9gknd 9738 4 264,343blood 264,343blood CD cord-010119-t1x9gknd 9738 5 donations donation NNS cord-010119-t1x9gknd 9738 6 were be VBD cord-010119-t1x9gknd 9738 7 studied study VBN cord-010119-t1x9gknd 9738 8 from from IN cord-010119-t1x9gknd 9738 9 August August NNP cord-010119-t1x9gknd 9738 10 2013 2013 CD cord-010119-t1x9gknd 9738 11 to to IN cord-010119-t1x9gknd 9738 12 December December NNP cord-010119-t1x9gknd 9738 13 2016 2016 CD cord-010119-t1x9gknd 9738 14 . . . cord-010119-t1x9gknd 9739 1 In in IN cord-010119-t1x9gknd 9739 2 the the DT cord-010119-t1x9gknd 9739 3 RBDC RBDC NNP cord-010119-t1x9gknd 9739 4 , , , cord-010119-t1x9gknd 9739 5 where where WRB cord-010119-t1x9gknd 9739 6 only only JJ cord-010119-t1x9gknd 9739 7 voluntary voluntary JJ cord-010119-t1x9gknd 9739 8 blood blood NN cord-010119-t1x9gknd 9739 9 donations donation NNS cord-010119-t1x9gknd 9739 10 are be VBP cord-010119-t1x9gknd 9739 11 recruited recruit VBN cord-010119-t1x9gknd 9739 12 , , , cord-010119-t1x9gknd 9739 13 the the DT cord-010119-t1x9gknd 9739 14 prevalence prevalence NN cord-010119-t1x9gknd 9739 15 was be VBD cord-010119-t1x9gknd 9739 16 18 18 CD cord-010119-t1x9gknd 9739 17 per per IN cord-010119-t1x9gknd 9739 18 100,000 100,000 CD cord-010119-t1x9gknd 9739 19 donations donation NNS cord-010119-t1x9gknd 9739 20 for for IN cord-010119-t1x9gknd 9739 21 HIV HIV NNP cord-010119-t1x9gknd 9740 1 ( ( -LRB- cord-010119-t1x9gknd 9740 2 IC95 IC95 NNP cord-010119-t1x9gknd 9740 3 % % NN cord-010119-t1x9gknd 9740 4 8 8 CD cord-010119-t1x9gknd 9740 5 - - SYM cord-010119-t1x9gknd 9740 6 34:100,000 34:100,000 CD cord-010119-t1x9gknd 9740 7 ) ) -RRB- cord-010119-t1x9gknd 9740 8 ; ; : cord-010119-t1x9gknd 9740 9 14 14 CD cord-010119-t1x9gknd 9740 10 per per IN cord-010119-t1x9gknd 9740 11 100,000 100,000 CD cord-010119-t1x9gknd 9740 12 for for IN cord-010119-t1x9gknd 9740 13 HBV HBV NNP cord-010119-t1x9gknd 9740 14 ( ( -LRB- cord-010119-t1x9gknd 9740 15 IC95 IC95 NNP cord-010119-t1x9gknd 9740 16 % % NN cord-010119-t1x9gknd 9740 17 7 7 CD cord-010119-t1x9gknd 9740 18 - - SYM cord-010119-t1x9gknd 9740 19 29:100,000 29:100,000 CD cord-010119-t1x9gknd 9740 20 ) ) -RRB- cord-010119-t1x9gknd 9740 21 and and CC cord-010119-t1x9gknd 9740 22 18 18 CD cord-010119-t1x9gknd 9740 23 per per IN cord-010119-t1x9gknd 9740 24 100,000 100,000 CD cord-010119-t1x9gknd 9740 25 for for IN cord-010119-t1x9gknd 9740 26 HCV HCV NNP cord-010119-t1x9gknd 9740 27 ( ( -LRB- cord-010119-t1x9gknd 9740 28 IC95 IC95 NNP cord-010119-t1x9gknd 9740 29 % % NN cord-010119-t1x9gknd 9740 30 8 8 CD cord-010119-t1x9gknd 9740 31 - - SYM cord-010119-t1x9gknd 9740 32 34:100,000 34:100,000 CD cord-010119-t1x9gknd 9740 33 ) ) -RRB- cord-010119-t1x9gknd 9740 34 . . . cord-010119-t1x9gknd 9741 1 In in IN cord-010119-t1x9gknd 9741 2 all all DT cord-010119-t1x9gknd 9741 3 other other JJ cord-010119-t1x9gknd 9741 4 centers center NNS cord-010119-t1x9gknd 9741 5 together together RB cord-010119-t1x9gknd 9741 6 , , , cord-010119-t1x9gknd 9741 7 where where WRB cord-010119-t1x9gknd 9741 8 voluntary voluntary JJ cord-010119-t1x9gknd 9741 9 and and CC cord-010119-t1x9gknd 9741 10 replacement replacement NN cord-010119-t1x9gknd 9741 11 blood blood NN cord-010119-t1x9gknd 9741 12 donations donation NNS cord-010119-t1x9gknd 9741 13 are be VBP cord-010119-t1x9gknd 9741 14 recruited recruit VBN cord-010119-t1x9gknd 9741 15 , , , cord-010119-t1x9gknd 9741 16 the the DT cord-010119-t1x9gknd 9741 17 prevalence prevalence NN cord-010119-t1x9gknd 9741 18 was be VBD cord-010119-t1x9gknd 9741 19 89 89 CD cord-010119-t1x9gknd 9741 20 per per IN cord-010119-t1x9gknd 9741 21 100,000 100,000 CD cord-010119-t1x9gknd 9741 22 donations donation NNS cord-010119-t1x9gknd 9741 23 for for IN cord-010119-t1x9gknd 9741 24 HIV HIV NNP cord-010119-t1x9gknd 9742 1 ( ( -LRB- cord-010119-t1x9gknd 9742 2 IC95 IC95 NNP cord-010119-t1x9gknd 9742 3 % % NN cord-010119-t1x9gknd 9742 4 77 77 CD cord-010119-t1x9gknd 9742 5 - - HYPH cord-010119-t1x9gknd 9742 6 103:100,000 103:100,000 CD cord-010119-t1x9gknd 9742 7 ) ) -RRB- cord-010119-t1x9gknd 9742 8 ; ; : cord-010119-t1x9gknd 9742 9 70 70 CD cord-010119-t1x9gknd 9742 10 per per IN cord-010119-t1x9gknd 9742 11 100,000 100,000 CD cord-010119-t1x9gknd 9742 12 for for IN cord-010119-t1x9gknd 9742 13 HBV HBV NNP cord-010119-t1x9gknd 9742 14 ( ( -LRB- cord-010119-t1x9gknd 9742 15 IC95 IC95 NNP cord-010119-t1x9gknd 9742 16 % % NN cord-010119-t1x9gknd 9742 17 59 59 CD cord-010119-t1x9gknd 9742 18 - - SYM cord-010119-t1x9gknd 9742 19 83:100,000 83:100,000 CD cord-010119-t1x9gknd 9742 20 ) ) -RRB- cord-010119-t1x9gknd 9743 1 and and CC cord-010119-t1x9gknd 9743 2 78 78 CD cord-010119-t1x9gknd 9743 3 per per IN cord-010119-t1x9gknd 9743 4 100,000 100,000 CD cord-010119-t1x9gknd 9743 5 for for IN cord-010119-t1x9gknd 9743 6 HCV HCV NNP cord-010119-t1x9gknd 9743 7 ( ( -LRB- cord-010119-t1x9gknd 9743 8 IC95 IC95 NNP cord-010119-t1x9gknd 9743 9 % % NN cord-010119-t1x9gknd 9743 10 66 66 CD cord-010119-t1x9gknd 9743 11 - - SYM cord-010119-t1x9gknd 9743 12 91:100,000 91:100,000 CD cord-010119-t1x9gknd 9743 13 ) ) -RRB- cord-010119-t1x9gknd 9743 14 . . . cord-010119-t1x9gknd 9744 1 Window window NN cord-010119-t1x9gknd 9744 2 period period NN cord-010119-t1x9gknd 9744 3 infections infection NNS cord-010119-t1x9gknd 9744 4 were be VBD cord-010119-t1x9gknd 9744 5 detected detect VBN cord-010119-t1x9gknd 9744 6 only only RB cord-010119-t1x9gknd 9744 7 in in IN cord-010119-t1x9gknd 9744 8 centers center NNS cord-010119-t1x9gknd 9744 9 recruiting recruit VBG cord-010119-t1x9gknd 9744 10 voluntary voluntary JJ cord-010119-t1x9gknd 9744 11 and and CC cord-010119-t1x9gknd 9744 12 replacement replacement NN cord-010119-t1x9gknd 9744 13 blood blood NN cord-010119-t1x9gknd 9744 14 donations donation NNS cord-010119-t1x9gknd 9744 15 , , , cord-010119-t1x9gknd 9744 16 giving give VBG cord-010119-t1x9gknd 9744 17 NAT NAT NNP cord-010119-t1x9gknd 9744 18 yield yield NN cord-010119-t1x9gknd 9744 19 rates rate NNS cord-010119-t1x9gknd 9744 20 of of IN cord-010119-t1x9gknd 9744 21 1 1 CD cord-010119-t1x9gknd 9744 22 : : SYM cord-010119-t1x9gknd 9744 23 66,086 66,086 CD cord-010119-t1x9gknd 9744 24 for for IN cord-010119-t1x9gknd 9744 25 HBV HBV NNP cord-010119-t1x9gknd 9744 26 ; ; : cord-010119-t1x9gknd 9744 27 1 1 CD cord-010119-t1x9gknd 9744 28 : : : cord-010119-t1x9gknd 9744 29 132,172 132,172 CD cord-010119-t1x9gknd 9744 30 for for IN cord-010119-t1x9gknd 9744 31 HIV HIV NNP cord-010119-t1x9gknd 9744 32 and and CC cord-010119-t1x9gknd 9744 33 1 1 CD cord-010119-t1x9gknd 9744 34 : : : cord-010119-t1x9gknd 9744 35 264,343 264,343 CD cord-010119-t1x9gknd 9744 36 for for IN cord-010119-t1x9gknd 9744 37 HCV HCV NNP cord-010119-t1x9gknd 9744 38 . . . cord-010119-t1x9gknd 9745 1 Conclusion conclusion NN cord-010119-t1x9gknd 9745 2 : : : cord-010119-t1x9gknd 9746 1 The the DT cord-010119-t1x9gknd 9746 2 HIV HIV NNP cord-010119-t1x9gknd 9746 3 , , , cord-010119-t1x9gknd 9746 4 HBV HBV NNP cord-010119-t1x9gknd 9746 5 and and CC cord-010119-t1x9gknd 9746 6 HCV HCV NNP cord-010119-t1x9gknd 9746 7 prevalence prevalence NN cord-010119-t1x9gknd 9746 8 was be VBD cord-010119-t1x9gknd 9746 9 lower low JJR cord-010119-t1x9gknd 9746 10 in in IN cord-010119-t1x9gknd 9746 11 a a DT cord-010119-t1x9gknd 9746 12 center center NN cord-010119-t1x9gknd 9746 13 where where WRB cord-010119-t1x9gknd 9746 14 the the DT cord-010119-t1x9gknd 9746 15 tasks task NNS cord-010119-t1x9gknd 9746 16 to to TO cord-010119-t1x9gknd 9746 17 sustain sustain VB cord-010119-t1x9gknd 9746 18 a a DT cord-010119-t1x9gknd 9746 19 Voluntary Voluntary NNP cord-010119-t1x9gknd 9746 20 Blood Blood NNP cord-010119-t1x9gknd 9746 21 Donor Donor NNP cord-010119-t1x9gknd 9746 22 program program NN cord-010119-t1x9gknd 9746 23 were be VBD cord-010119-t1x9gknd 9746 24 developed develop VBN cord-010119-t1x9gknd 9746 25 . . . cord-010119-t1x9gknd 9747 1 NAT NAT NNP cord-010119-t1x9gknd 9747 2 yield yield NN cord-010119-t1x9gknd 9747 3 rates rate NNS cord-010119-t1x9gknd 9747 4 could could MD cord-010119-t1x9gknd 9747 5 be be VB cord-010119-t1x9gknd 9747 6 reduced reduce VBN cord-010119-t1x9gknd 9747 7 in in IN cord-010119-t1x9gknd 9747 8 the the DT cord-010119-t1x9gknd 9747 9 region region NN cord-010119-t1x9gknd 9747 10 if if IN cord-010119-t1x9gknd 9747 11 this this DT cord-010119-t1x9gknd 9747 12 program program NN cord-010119-t1x9gknd 9747 13 could could MD cord-010119-t1x9gknd 9747 14 completely completely RB cord-010119-t1x9gknd 9747 15 be be VB cord-010119-t1x9gknd 9747 16 applied apply VBN cord-010119-t1x9gknd 9747 17 in in IN cord-010119-t1x9gknd 9747 18 all all DT cord-010119-t1x9gknd 9747 19 centers center NNS cord-010119-t1x9gknd 9747 20 . . . cord-010119-t1x9gknd 9748 1 Mechanisms mechanism NNS cord-010119-t1x9gknd 9748 2 leading lead VBG cord-010119-t1x9gknd 9748 3 to to IN cord-010119-t1x9gknd 9748 4 OBI OBI NNP cord-010119-t1x9gknd 9748 5 include include VBP cord-010119-t1x9gknd 9748 6 various various JJ cord-010119-t1x9gknd 9748 7 factors factor NNS cord-010119-t1x9gknd 9748 8 such such JJ cord-010119-t1x9gknd 9748 9 as as IN cord-010119-t1x9gknd 9748 10 imperfect imperfect JJ cord-010119-t1x9gknd 9748 11 host host NN cord-010119-t1x9gknd 9748 12 's 's POS cord-010119-t1x9gknd 9748 13 immune immune JJ cord-010119-t1x9gknd 9748 14 response response NN cord-010119-t1x9gknd 9748 15 and and CC cord-010119-t1x9gknd 9748 16 viral viral JJ cord-010119-t1x9gknd 9748 17 variation variation NN cord-010119-t1x9gknd 9748 18 factors factor NNS cord-010119-t1x9gknd 9748 19 . . . cord-010119-t1x9gknd 9749 1 This this DT cord-010119-t1x9gknd 9749 2 study study NN cord-010119-t1x9gknd 9749 3 was be VBD cord-010119-t1x9gknd 9749 4 to to TO cord-010119-t1x9gknd 9749 5 determine determine VB cord-010119-t1x9gknd 9749 6 the the DT cord-010119-t1x9gknd 9749 7 viral viral JJ cord-010119-t1x9gknd 9749 8 loads load NNS cord-010119-t1x9gknd 9749 9 of of IN cord-010119-t1x9gknd 9749 10 OBI OBI NNP cord-010119-t1x9gknd 9749 11 under under IN cord-010119-t1x9gknd 9749 12 currently currently RB cord-010119-t1x9gknd 9749 13 recruitment recruitment NN cord-010119-t1x9gknd 9749 14 and and CC cord-010119-t1x9gknd 9749 15 screening screening NN cord-010119-t1x9gknd 9749 16 among among IN cord-010119-t1x9gknd 9749 17 blood blood NN cord-010119-t1x9gknd 9749 18 donors donor NNS cord-010119-t1x9gknd 9749 19 in in IN cord-010119-t1x9gknd 9749 20 five five CD cord-010119-t1x9gknd 9749 21 Blood blood NN cord-010119-t1x9gknd 9749 22 services service NNS cord-010119-t1x9gknd 9749 23 of of IN cord-010119-t1x9gknd 9749 24 Zhejiang Zhejiang NNP cord-010119-t1x9gknd 9749 25 Province Province NNP cord-010119-t1x9gknd 9749 26 , , , cord-010119-t1x9gknd 9749 27 China China NNP cord-010119-t1x9gknd 9749 28 . . . cord-010119-t1x9gknd 9750 1 Study Study NNP cord-010119-t1x9gknd 9750 2 Design Design NNP cord-010119-t1x9gknd 9750 3 / / SYM cord-010119-t1x9gknd 9750 4 Method method NN cord-010119-t1x9gknd 9750 5 : : : cord-010119-t1x9gknd 9750 6 Before before IN cord-010119-t1x9gknd 9750 7 donation donation NN cord-010119-t1x9gknd 9750 8 , , , cord-010119-t1x9gknd 9750 9 the the DT cord-010119-t1x9gknd 9750 10 donors donor NNS cord-010119-t1x9gknd 9750 11 were be VBD cord-010119-t1x9gknd 9750 12 screened screen VBN cord-010119-t1x9gknd 9750 13 and and CC cord-010119-t1x9gknd 9750 14 precluded preclude VBN cord-010119-t1x9gknd 9750 15 with with IN cord-010119-t1x9gknd 9750 16 HBsAg hbsag ADD cord-010119-t1x9gknd 9750 17 preliminary preliminary JJ cord-010119-t1x9gknd 9750 18 test test NN cord-010119-t1x9gknd 9750 19 positive positive JJ cord-010119-t1x9gknd 9750 20 and and CC cord-010119-t1x9gknd 9750 21 ALT alt NN cord-010119-t1x9gknd 9750 22 level level NN cord-010119-t1x9gknd 9750 23 abnormal abnormal JJ cord-010119-t1x9gknd 9750 24 . . . cord-010119-t1x9gknd 9751 1 Following follow VBG cord-010119-t1x9gknd 9751 2 , , , cord-010119-t1x9gknd 9751 3 the the DT cord-010119-t1x9gknd 9751 4 samples sample NNS cord-010119-t1x9gknd 9751 5 were be VBD cord-010119-t1x9gknd 9751 6 detected detect VBN cord-010119-t1x9gknd 9751 7 for for IN cord-010119-t1x9gknd 9751 8 HBsAg hbsag ADD cord-010119-t1x9gknd 9751 9 twice twice PDT cord-010119-t1x9gknd 9751 10 using use VBG cord-010119-t1x9gknd 9751 11 different different JJ cord-010119-t1x9gknd 9751 12 ELISA ELISA NNP cord-010119-t1x9gknd 9751 13 reagents reagent NNS cord-010119-t1x9gknd 9751 14 and and CC cord-010119-t1x9gknd 9751 15 HBV HBV NNP cord-010119-t1x9gknd 9751 16 DNA DNA NNP cord-010119-t1x9gknd 9751 17 using use VBG cord-010119-t1x9gknd 9751 18 TMA TMA NNP cord-010119-t1x9gknd 9751 19 or or CC cord-010119-t1x9gknd 9751 20 QT QT NNP cord-010119-t1x9gknd 9751 21 - - HYPH cord-010119-t1x9gknd 9751 22 PCR pcr NN cord-010119-t1x9gknd 9751 23 techniques technique NNS cord-010119-t1x9gknd 9751 24 . . . cord-010119-t1x9gknd 9752 1 Then then RB cord-010119-t1x9gknd 9752 2 , , , cord-010119-t1x9gknd 9752 3 the the DT cord-010119-t1x9gknd 9752 4 samples sample NNS cord-010119-t1x9gknd 9752 5 with with IN cord-010119-t1x9gknd 9752 6 HBV HBV NNP cord-010119-t1x9gknd 9752 7 DNA DNA NNP cord-010119-t1x9gknd 9752 8 positive positive JJ cord-010119-t1x9gknd 9752 9 and and CC cord-010119-t1x9gknd 9752 10 ELISA ELISA NNP cord-010119-t1x9gknd 9752 11 negative negative JJ cord-010119-t1x9gknd 9752 12 were be VBD cord-010119-t1x9gknd 9752 13 tested test VBN cord-010119-t1x9gknd 9752 14 for for IN cord-010119-t1x9gknd 9752 15 the the DT cord-010119-t1x9gknd 9752 16 viral viral JJ cord-010119-t1x9gknd 9752 17 loads load NNS cord-010119-t1x9gknd 9752 18 using use VBG cord-010119-t1x9gknd 9752 19 TaqMan TaqMan NNP cord-010119-t1x9gknd 9752 20 technique technique NN cord-010119-t1x9gknd 9752 21 in in IN cord-010119-t1x9gknd 9752 22 COBAS COBAS NNP cord-010119-t1x9gknd 9752 23 S201 s201 POS cord-010119-t1x9gknd 9752 24 system system NN cord-010119-t1x9gknd 9752 25 . . . cord-010119-t1x9gknd 9753 1 HBV HBV NNP cord-010119-t1x9gknd 9753 2 S S NNP cord-010119-t1x9gknd 9753 3 region region NN cord-010119-t1x9gknd 9753 4 was be VBD cord-010119-t1x9gknd 9753 5 also also RB cord-010119-t1x9gknd 9753 6 sequenced sequence VBN cord-010119-t1x9gknd 9753 7 . . . cord-010119-t1x9gknd 9754 1 Results/ Results/ . cord-010119-t1x9gknd 9755 1 Finding finding NN cord-010119-t1x9gknd 9755 2 : : : cord-010119-t1x9gknd 9756 1 234 234 CD cord-010119-t1x9gknd 9756 2 OBI OBI NNP cord-010119-t1x9gknd 9756 3 were be VBD cord-010119-t1x9gknd 9756 4 found find VBN cord-010119-t1x9gknd 9756 5 in in IN cord-010119-t1x9gknd 9756 6 the the DT cord-010119-t1x9gknd 9756 7 230,000 230,000 CD cord-010119-t1x9gknd 9756 8 donations donation NNS cord-010119-t1x9gknd 9756 9 . . . cord-010119-t1x9gknd 9757 1 In in IN cord-010119-t1x9gknd 9757 2 the the DT cord-010119-t1x9gknd 9757 3 viral viral JJ cord-010119-t1x9gknd 9757 4 loads load NNS cord-010119-t1x9gknd 9757 5 assay assay NN cord-010119-t1x9gknd 9757 6 , , , cord-010119-t1x9gknd 9757 7 43 43 CD cord-010119-t1x9gknd 9757 8 samples sample NNS cord-010119-t1x9gknd 9757 9 were be VBD cord-010119-t1x9gknd 9757 10 negative negative JJ cord-010119-t1x9gknd 9757 11 and and CC cord-010119-t1x9gknd 9757 12 104 104 CD cord-010119-t1x9gknd 9757 13 samples sample NNS cord-010119-t1x9gknd 9757 14 ' ' POS cord-010119-t1x9gknd 9757 15 viral viral JJ cord-010119-t1x9gknd 9757 16 loads load NNS cord-010119-t1x9gknd 9757 17 were be VBD cord-010119-t1x9gknd 9757 18 lower low JJR cord-010119-t1x9gknd 9757 19 20IU 20iu CD cord-010119-t1x9gknd 9757 20 / / SYM cord-010119-t1x9gknd 9757 21 ml ml NN cord-010119-t1x9gknd 9757 22 . . . cord-010119-t1x9gknd 9758 1 The the DT cord-010119-t1x9gknd 9758 2 mean mean JJ cord-010119-t1x9gknd 9758 3 viral viral JJ cord-010119-t1x9gknd 9758 4 loads load NNS cord-010119-t1x9gknd 9758 5 was be VBD cord-010119-t1x9gknd 9758 6 1.85 1.85 CD cord-010119-t1x9gknd 9758 7 6 6 CD cord-010119-t1x9gknd 9758 8 0.41 0.41 CD cord-010119-t1x9gknd 9759 1 ( ( -LRB- cord-010119-t1x9gknd 9759 2 log10 log10 NN cord-010119-t1x9gknd 9759 3 ) ) -RRB- cord-010119-t1x9gknd 9759 4 IU IU NNP cord-010119-t1x9gknd 9759 5 / / , cord-010119-t1x9gknd 9759 6 ml ml NN cord-010119-t1x9gknd 9759 7 in in IN cord-010119-t1x9gknd 9759 8 other other JJ cord-010119-t1x9gknd 9759 9 87 87 CD cord-010119-t1x9gknd 9759 10 samples sample NNS cord-010119-t1x9gknd 9759 11 , , , cord-010119-t1x9gknd 9759 12 while while IN cord-010119-t1x9gknd 9759 13 the the DT cord-010119-t1x9gknd 9759 14 mean mean JJ cord-010119-t1x9gknd 9759 15 viral viral JJ cord-010119-t1x9gknd 9759 16 loads load NNS cord-010119-t1x9gknd 9759 17 with with IN cord-010119-t1x9gknd 9759 18 HBsAg1 HBsAg1 NNP cord-010119-t1x9gknd 9759 19 / / SYM cord-010119-t1x9gknd 9759 20 HBV HBV NNP cord-010119-t1x9gknd 9759 21 DNA1 DNA1 NNP cord-010119-t1x9gknd 9759 22 samples sample NNS cord-010119-t1x9gknd 9759 23 was be VBD cord-010119-t1x9gknd 9759 24 2.38 2.38 CD cord-010119-t1x9gknd 9759 25 6 6 CD cord-010119-t1x9gknd 9759 26 0.83 0.83 CD cord-010119-t1x9gknd 9759 27 ( ( -LRB- cord-010119-t1x9gknd 9759 28 log10 log10 NN cord-010119-t1x9gknd 9759 29 ) ) -RRB- cord-010119-t1x9gknd 9760 1 IU IU NNP cord-010119-t1x9gknd 9760 2 / / , cord-010119-t1x9gknd 9760 3 ml ml NN cord-010119-t1x9gknd 9760 4 . . . cord-010119-t1x9gknd 9761 1 60 60 CD cord-010119-t1x9gknd 9761 2 samples sample NNS cord-010119-t1x9gknd 9761 3 of of IN cord-010119-t1x9gknd 9761 4 OBIs obi NNS cord-010119-t1x9gknd 9761 5 have have VBP cord-010119-t1x9gknd 9761 6 analyzed analyze VBN cord-010119-t1x9gknd 9761 7 the the DT cord-010119-t1x9gknd 9761 8 HBV HBV NNP cord-010119-t1x9gknd 9761 9 genotype genotype NN cord-010119-t1x9gknd 9761 10 , , , cord-010119-t1x9gknd 9761 11 which which WDT cord-010119-t1x9gknd 9761 12 B b NN cord-010119-t1x9gknd 9761 13 was be VBD cord-010119-t1x9gknd 9761 14 the the DT cord-010119-t1x9gknd 9761 15 most most RBS cord-010119-t1x9gknd 9761 16 prevalent prevalent JJ cord-010119-t1x9gknd 9761 17 subtype subtype NN cord-010119-t1x9gknd 9761 18 ( ( -LRB- cord-010119-t1x9gknd 9761 19 69.0 69.0 CD cord-010119-t1x9gknd 9761 20 % % NN cord-010119-t1x9gknd 9761 21 ) ) -RRB- cord-010119-t1x9gknd 9761 22 and and CC cord-010119-t1x9gknd 9761 23 the the DT cord-010119-t1x9gknd 9761 24 other other JJ cord-010119-t1x9gknd 9761 25 was be VBD cord-010119-t1x9gknd 9761 26 HBV HBV NNP cord-010119-t1x9gknd 9761 27 C C NNP cord-010119-t1x9gknd 9761 28 genotype(31.0 genotype(31.0 NNP cord-010119-t1x9gknd 9761 29 % % NN cord-010119-t1x9gknd 9761 30 ) ) -RRB- cord-010119-t1x9gknd 9761 31 . . . cord-010119-t1x9gknd 9762 1 Compared compare VBN cord-010119-t1x9gknd 9762 2 the the DT cord-010119-t1x9gknd 9762 3 samples sample NNS cord-010119-t1x9gknd 9762 4 with with IN cord-010119-t1x9gknd 9762 5 HBsAg1 HBsAg1 NNP cord-010119-t1x9gknd 9762 6 / / SYM cord-010119-t1x9gknd 9762 7 HBV HBV NNP cord-010119-t1x9gknd 9762 8 DNA1 DNA1 NNP cord-010119-t1x9gknd 9762 9 , , , cord-010119-t1x9gknd 9762 10 We -PRON- PRP cord-010119-t1x9gknd 9762 11 found find VBD cord-010119-t1x9gknd 9762 12 two two CD cord-010119-t1x9gknd 9762 13 OBI obi NN cord-010119-t1x9gknd 9762 14 samples sample NNS cord-010119-t1x9gknd 9762 15 carrying carry VBG cord-010119-t1x9gknd 9762 16 with with IN cord-010119-t1x9gknd 9762 17 318 318 CD cord-010119-t1x9gknd 9762 18 T t NN cord-010119-t1x9gknd 9763 1 > > XX cord-010119-t1x9gknd 9764 1 C C NNP cord-010119-t1x9gknd 9764 2 mutation mutation NN cord-010119-t1x9gknd 9764 3 , , , cord-010119-t1x9gknd 9764 4 which which WDT cord-010119-t1x9gknd 9764 5 could could MD cord-010119-t1x9gknd 9764 6 cause cause VB cord-010119-t1x9gknd 9764 7 an an DT cord-010119-t1x9gknd 9764 8 amino amino NN cord-010119-t1x9gknd 9764 9 acid acid NN cord-010119-t1x9gknd 9765 1 S55F. S55F. NNP cord-010119-t1x9gknd 9765 2 Conclusion conclusion NN cord-010119-t1x9gknd 9765 3 : : : cord-010119-t1x9gknd 9766 1 In in IN cord-010119-t1x9gknd 9766 2 this this DT cord-010119-t1x9gknd 9766 3 study study NN cord-010119-t1x9gknd 9766 4 , , , cord-010119-t1x9gknd 9766 5 the the DT cord-010119-t1x9gknd 9766 6 viral viral JJ cord-010119-t1x9gknd 9766 7 loads load NNS cord-010119-t1x9gknd 9766 8 of of IN cord-010119-t1x9gknd 9766 9 OBI obi NN cord-010119-t1x9gknd 9766 10 infection infection NN cord-010119-t1x9gknd 9766 11 in in IN cord-010119-t1x9gknd 9766 12 donors donor NNS cord-010119-t1x9gknd 9766 13 was be VBD cord-010119-t1x9gknd 9766 14 much much RB cord-010119-t1x9gknd 9766 15 low low JJ cord-010119-t1x9gknd 9766 16 than than IN cord-010119-t1x9gknd 9766 17 HBsAg1 HBsAg1 NNP cord-010119-t1x9gknd 9766 18 / / SYM cord-010119-t1x9gknd 9766 19 HBV HBV NNP cord-010119-t1x9gknd 9766 20 DNA1 DNA1 NNP cord-010119-t1x9gknd 9766 21 , , , cord-010119-t1x9gknd 9766 22 and and CC cord-010119-t1x9gknd 9766 23 some some DT cord-010119-t1x9gknd 9766 24 unique unique JJ cord-010119-t1x9gknd 9766 25 variation variation NN cord-010119-t1x9gknd 9766 26 was be VBD cord-010119-t1x9gknd 9766 27 identified identify VBN cord-010119-t1x9gknd 9766 28 in in IN cord-010119-t1x9gknd 9766 29 the the DT cord-010119-t1x9gknd 9766 30 OBI OBI NNP cord-010119-t1x9gknd 9766 31 individuals individual NNS cord-010119-t1x9gknd 9766 32 . . . cord-010119-t1x9gknd 9767 1 195A 195a CD cord-010119-t1x9gknd 9767 2 TRANSFUSION transfusion NN cord-010119-t1x9gknd 9767 3 in in IN cord-010119-t1x9gknd 9767 4 general general JJ cord-010119-t1x9gknd 9767 5 population population NN cord-010119-t1x9gknd 9767 6 . . . cord-010119-t1x9gknd 9768 1 Screening screening NN cord-010119-t1x9gknd 9768 2 of of IN cord-010119-t1x9gknd 9768 3 blood blood NN cord-010119-t1x9gknd 9768 4 donors donor NNS cord-010119-t1x9gknd 9768 5 for for IN cord-010119-t1x9gknd 9768 6 HBV HBV NNP cord-010119-t1x9gknd 9768 7 in in IN cord-010119-t1x9gknd 9768 8 India India NNP cord-010119-t1x9gknd 9768 9 is be VBZ cord-010119-t1x9gknd 9768 10 primarily primarily RB cord-010119-t1x9gknd 9768 11 based base VBN cord-010119-t1x9gknd 9768 12 upon upon IN cord-010119-t1x9gknd 9768 13 detection detection NN cord-010119-t1x9gknd 9768 14 of of IN cord-010119-t1x9gknd 9768 15 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 9768 16 B B NNP cord-010119-t1x9gknd 9768 17 surface surface NN cord-010119-t1x9gknd 9768 18 antigen antigen NN cord-010119-t1x9gknd 9768 19 ( ( -LRB- cord-010119-t1x9gknd 9768 20 HBsAg HBsAg NNP cord-010119-t1x9gknd 9768 21 ) ) -RRB- cord-010119-t1x9gknd 9768 22 in in IN cord-010119-t1x9gknd 9768 23 donor donor NN cord-010119-t1x9gknd 9768 24 's 's POS cord-010119-t1x9gknd 9768 25 sera sera NNP cord-010119-t1x9gknd 9768 26 . . . cord-010119-t1x9gknd 9769 1 The the DT cord-010119-t1x9gknd 9769 2 current current JJ cord-010119-t1x9gknd 9769 3 study study NN cord-010119-t1x9gknd 9769 4 was be VBD cord-010119-t1x9gknd 9769 5 undertaken undertake VBN cord-010119-t1x9gknd 9769 6 to to TO cord-010119-t1x9gknd 9769 7 determine determine VB cord-010119-t1x9gknd 9769 8 the the DT cord-010119-t1x9gknd 9769 9 prevalence prevalence NN cord-010119-t1x9gknd 9769 10 of of IN cord-010119-t1x9gknd 9769 11 occult occult JJ cord-010119-t1x9gknd 9769 12 HBV HBV NNP cord-010119-t1x9gknd 9769 13 infection infection NN cord-010119-t1x9gknd 9769 14 ( ( -LRB- cord-010119-t1x9gknd 9769 15 OBI OBI NNP cord-010119-t1x9gknd 9769 16 ) ) -RRB- cord-010119-t1x9gknd 9769 17 in in IN cord-010119-t1x9gknd 9769 18 voluntary voluntary JJ cord-010119-t1x9gknd 9769 19 blood blood NN cord-010119-t1x9gknd 9769 20 donors donor NNS cord-010119-t1x9gknd 9769 21 and and CC cord-010119-t1x9gknd 9769 22 to to TO cord-010119-t1x9gknd 9769 23 analyze analyze VB cord-010119-t1x9gknd 9769 24 the the DT cord-010119-t1x9gknd 9769 25 burden burden NN cord-010119-t1x9gknd 9769 26 of of IN cord-010119-t1x9gknd 9769 27 HBV HBV NNP cord-010119-t1x9gknd 9769 28 window window NN cord-010119-t1x9gknd 9769 29 period period NN cord-010119-t1x9gknd 9769 30 donations donation NNS cord-010119-t1x9gknd 9769 31 . . . cord-010119-t1x9gknd 9770 1 Study Study NNP cord-010119-t1x9gknd 9770 2 Design Design NNP cord-010119-t1x9gknd 9770 3 / / SYM cord-010119-t1x9gknd 9770 4 Method method NN cord-010119-t1x9gknd 9770 5 : : : cord-010119-t1x9gknd 9770 6 This this DT cord-010119-t1x9gknd 9770 7 is be VBZ cord-010119-t1x9gknd 9770 8 a a DT cord-010119-t1x9gknd 9770 9 prospective prospective JJ cord-010119-t1x9gknd 9770 10 , , , cord-010119-t1x9gknd 9770 11 observational observational JJ cord-010119-t1x9gknd 9770 12 , , , cord-010119-t1x9gknd 9770 13 mono mono NN cord-010119-t1x9gknd 9770 14 - - HYPH cord-010119-t1x9gknd 9770 15 centric centric JJ cord-010119-t1x9gknd 9770 16 study study NN cord-010119-t1x9gknd 9770 17 performed perform VBN cord-010119-t1x9gknd 9770 18 in in IN cord-010119-t1x9gknd 9770 19 a a DT cord-010119-t1x9gknd 9770 20 national national JJ cord-010119-t1x9gknd 9770 21 accreditation accreditation NN cord-010119-t1x9gknd 9770 22 board board NN cord-010119-t1x9gknd 9770 23 for for IN cord-010119-t1x9gknd 9770 24 hospitals hospital NNS cord-010119-t1x9gknd 9770 25 ( ( -LRB- cord-010119-t1x9gknd 9770 26 NABH NABH NNP cord-010119-t1x9gknd 9770 27 ) ) -RRB- cord-010119-t1x9gknd 9771 1 accredited accredit VBN cord-010119-t1x9gknd 9771 2 apex apex NNP cord-010119-t1x9gknd 9771 3 blood blood NNP cord-010119-t1x9gknd 9771 4 bank bank NN cord-010119-t1x9gknd 9771 5 , , , cord-010119-t1x9gknd 9771 6 located locate VBN cord-010119-t1x9gknd 9771 7 in in IN cord-010119-t1x9gknd 9771 8 Maharashtra Maharashtra NNP cord-010119-t1x9gknd 9771 9 state state NN cord-010119-t1x9gknd 9771 10 , , , cord-010119-t1x9gknd 9771 11 India India NNP cord-010119-t1x9gknd 9771 12 . . . cord-010119-t1x9gknd 9772 1 Monolisa Monolisa NNP cord-010119-t1x9gknd 9773 1 HBsAg HBsAg NNP cord-010119-t1x9gknd 9773 2 ULTRA ULTRA NNP cord-010119-t1x9gknd 9774 1 ( ( -LRB- cord-010119-t1x9gknd 9774 2 Bio Bio NNP cord-010119-t1x9gknd 9774 3 - - HYPH cord-010119-t1x9gknd 9774 4 Rad Rad NNP cord-010119-t1x9gknd 9774 5 , , , cord-010119-t1x9gknd 9774 6 France)sandwich France)sandwich NNP cord-010119-t1x9gknd 9774 7 type type NN cord-010119-t1x9gknd 9774 8 ELISA ELISA NNP cord-010119-t1x9gknd 9774 9 using use VBG cord-010119-t1x9gknd 9774 10 monoclonal monoclonal JJ cord-010119-t1x9gknd 9774 11 and and CC cord-010119-t1x9gknd 9774 12 polyclonal polyclonal JJ cord-010119-t1x9gknd 9774 13 antibodies antibody NNS cord-010119-t1x9gknd 9774 14 was be VBD cord-010119-t1x9gknd 9774 15 used use VBN cord-010119-t1x9gknd 9774 16 for for IN cord-010119-t1x9gknd 9774 17 HBsAg hbsag ADD cord-010119-t1x9gknd 9774 18 detection detection NN cord-010119-t1x9gknd 9774 19 in in IN cord-010119-t1x9gknd 9774 20 donor donor NN cord-010119-t1x9gknd 9774 21 's 's POS cord-010119-t1x9gknd 9774 22 sera sera NNP cord-010119-t1x9gknd 9774 23 . . . cord-010119-t1x9gknd 9775 1 All all PDT cord-010119-t1x9gknd 9775 2 the the DT cord-010119-t1x9gknd 9775 3 ELISA ELISA NNP cord-010119-t1x9gknd 9775 4 non non JJ cord-010119-t1x9gknd 9775 5 - - JJ cord-010119-t1x9gknd 9775 6 reactive reactive JJ cord-010119-t1x9gknd 9775 7 samples sample NNS cord-010119-t1x9gknd 9775 8 were be VBD cord-010119-t1x9gknd 9775 9 also also RB cord-010119-t1x9gknd 9775 10 tested test VBN cord-010119-t1x9gknd 9775 11 by by IN cord-010119-t1x9gknd 9775 12 an an DT cord-010119-t1x9gknd 9775 13 additional additional JJ cord-010119-t1x9gknd 9775 14 real real JJ cord-010119-t1x9gknd 9775 15 time time NN cord-010119-t1x9gknd 9775 16 multiplex multiplex NN cord-010119-t1x9gknd 9775 17 polymerase polymerase NN cord-010119-t1x9gknd 9775 18 chain chain NN cord-010119-t1x9gknd 9775 19 reaction reaction NN cord-010119-t1x9gknd 9775 20 ( ( -LRB- cord-010119-t1x9gknd 9775 21 MPX MPX NNP cord-010119-t1x9gknd 9775 22 - - HYPH cord-010119-t1x9gknd 9775 23 PCR PCR NNP cord-010119-t1x9gknd 9775 24 ) ) -RRB- cord-010119-t1x9gknd 9775 25 by by IN cord-010119-t1x9gknd 9775 26 cobasV cobasv CC cord-010119-t1x9gknd 9775 27 R R NNP cord-010119-t1x9gknd 9775 28 TaqScreen taqscreen NN cord-010119-t1x9gknd 9775 29 MPX MPX NNP cord-010119-t1x9gknd 9775 30 test test NN cord-010119-t1x9gknd 9775 31 . . . cord-010119-t1x9gknd 9776 1 The the DT cord-010119-t1x9gknd 9776 2 donors donor NNS cord-010119-t1x9gknd 9776 3 which which WDT cord-010119-t1x9gknd 9776 4 were be VBD cord-010119-t1x9gknd 9776 5 found find VBN cord-010119-t1x9gknd 9776 6 to to TO cord-010119-t1x9gknd 9776 7 be be VB cord-010119-t1x9gknd 9776 8 positive positive JJ cord-010119-t1x9gknd 9776 9 for for IN cord-010119-t1x9gknd 9776 10 HBV HBV NNP cord-010119-t1x9gknd 9776 11 DNA DNA NNP cord-010119-t1x9gknd 9776 12 were be VBD cord-010119-t1x9gknd 9776 13 followed follow VBN cord-010119-t1x9gknd 9776 14 upat upat JJ cord-010119-t1x9gknd 9776 15 15 15 CD cord-010119-t1x9gknd 9776 16 th th CD cord-010119-t1x9gknd 9776 17 days day NNS cord-010119-t1x9gknd 9776 18 , , , cord-010119-t1x9gknd 9776 19 1month 1month CD cord-010119-t1x9gknd 9776 20 , , , cord-010119-t1x9gknd 9776 21 3 3 CD cord-010119-t1x9gknd 9776 22 months month NNS cord-010119-t1x9gknd 9776 23 & & CC cord-010119-t1x9gknd 9776 24 6 6 CD cord-010119-t1x9gknd 9776 25 months month NNS cord-010119-t1x9gknd 9776 26 by by IN cord-010119-t1x9gknd 9776 27 Monolisa Monolisa NNP cord-010119-t1x9gknd 9776 28 HBsAg hbsag ADD cord-010119-t1x9gknd 9776 29 ULTRA ULTRA NNP cord-010119-t1x9gknd 9777 1 ( ( -LRB- cord-010119-t1x9gknd 9777 2 Bio Bio NNP cord-010119-t1x9gknd 9777 3 - - HYPH cord-010119-t1x9gknd 9777 4 Rad Rad NNP cord-010119-t1x9gknd 9777 5 , , , cord-010119-t1x9gknd 9777 6 France France NNP cord-010119-t1x9gknd 9777 7 ) ) -RRB- cord-010119-t1x9gknd 9777 8 to to TO cord-010119-t1x9gknd 9777 9 analyze analyze VB cord-010119-t1x9gknd 9777 10 interval interval NN cord-010119-t1x9gknd 9777 11 of of IN cord-010119-t1x9gknd 9777 12 window window NN cord-010119-t1x9gknd 9777 13 period period NN cord-010119-t1x9gknd 9777 14 and and CC cord-010119-t1x9gknd 9777 15 to to TO cord-010119-t1x9gknd 9777 16 delineate delineate VB cord-010119-t1x9gknd 9777 17 the the DT cord-010119-t1x9gknd 9777 18 window window NN cord-010119-t1x9gknd 9777 19 period period NN cord-010119-t1x9gknd 9777 20 donations donation NNS cord-010119-t1x9gknd 9777 21 ( ( -LRB- cord-010119-t1x9gknd 9777 22 WPD WPD NNP cord-010119-t1x9gknd 9777 23 ) ) -RRB- cord-010119-t1x9gknd 9777 24 & & CC cord-010119-t1x9gknd 9777 25 true true JJ cord-010119-t1x9gknd 9777 26 OBI OBI NNP cord-010119-t1x9gknd 9777 27 . . . cord-010119-t1x9gknd 9778 1 Background Background NNP cord-010119-t1x9gknd 9778 2 / / SYM cord-010119-t1x9gknd 9778 3 Case Case NNP cord-010119-t1x9gknd 9778 4 Studies Studies NNPS cord-010119-t1x9gknd 9778 5 : : : cord-010119-t1x9gknd 9778 6 Occult occult JJ cord-010119-t1x9gknd 9778 7 hepatitis hepatitis NN cord-010119-t1x9gknd 9778 8 B b NN cord-010119-t1x9gknd 9778 9 infection infection NN cord-010119-t1x9gknd 9779 1 ( ( -LRB- cord-010119-t1x9gknd 9779 2 OBI OBI NNP cord-010119-t1x9gknd 9779 3 ) ) -RRB- cord-010119-t1x9gknd 9779 4 is be VBZ cord-010119-t1x9gknd 9779 5 characterized characterize VBN cord-010119-t1x9gknd 9779 6 by by IN cord-010119-t1x9gknd 9779 7 hepatitis hepatitis NN cord-010119-t1x9gknd 9779 8 B B NNP cord-010119-t1x9gknd 9779 9 virus virus NN cord-010119-t1x9gknd 9779 10 ( ( -LRB- cord-010119-t1x9gknd 9779 11 HBV HBV NNP cord-010119-t1x9gknd 9779 12 ) ) -RRB- cord-010119-t1x9gknd 9779 13 DNA dna NN cord-010119-t1x9gknd 9779 14 - - HYPH cord-010119-t1x9gknd 9779 15 positive positive JJ cord-010119-t1x9gknd 9779 16 , , , cord-010119-t1x9gknd 9779 17 but but CC cord-010119-t1x9gknd 9779 18 HBV HBV NNP cord-010119-t1x9gknd 9779 19 surface surface VBP cord-010119-t1x9gknd 9779 20 antigen antigen NN cord-010119-t1x9gknd 9779 21 ( ( -LRB- cord-010119-t1x9gknd 9779 22 HBsAg HBsAg NNP cord-010119-t1x9gknd 9779 23 ) ) -RRB- cord-010119-t1x9gknd 9779 24 -negative -negative NN cord-010119-t1x9gknd 9779 25 . . . cord-010119-t1x9gknd 9780 1 Since since IN cord-010119-t1x9gknd 9780 2 May May NNP cord-010119-t1x9gknd 9780 3 2015 2015 CD cord-010119-t1x9gknd 9780 4 , , , cord-010119-t1x9gknd 9780 5 we -PRON- PRP cord-010119-t1x9gknd 9780 6 have have VBP cord-010119-t1x9gknd 9780 7 been be VBN cord-010119-t1x9gknd 9780 8 testing test VBG cord-010119-t1x9gknd 9780 9 apheresis apheresis NN cord-010119-t1x9gknd 9780 10 donors donor NNS cord-010119-t1x9gknd 9780 11 for for IN cord-010119-t1x9gknd 9780 12 HBV HBV NNP cord-010119-t1x9gknd 9780 13 nucleic nucleic JJ cord-010119-t1x9gknd 9780 14 acids acid NNS cord-010119-t1x9gknd 9780 15 and and CC cord-010119-t1x9gknd 9780 16 improvements improvement NNS cord-010119-t1x9gknd 9780 17 in in IN cord-010119-t1x9gknd 9780 18 laboratory laboratory NN cord-010119-t1x9gknd 9780 19 testing testing NN cord-010119-t1x9gknd 9780 20 have have VBP cord-010119-t1x9gknd 9780 21 reduced reduce VBN cord-010119-t1x9gknd 9780 22 the the DT cord-010119-t1x9gknd 9780 23 risk risk NN cord-010119-t1x9gknd 9780 24 of of IN cord-010119-t1x9gknd 9780 25 transfusion transfusion NN cord-010119-t1x9gknd 9780 26 - - HYPH cord-010119-t1x9gknd 9780 27 transmitted transmit VBN cord-010119-t1x9gknd 9780 28 infection infection NN cord-010119-t1x9gknd 9780 29 . . . cord-010119-t1x9gknd 9781 1 The the DT cord-010119-t1x9gknd 9781 2 number number NN cord-010119-t1x9gknd 9781 3 of of IN cord-010119-t1x9gknd 9781 4 apheresis apheresis NN cord-010119-t1x9gknd 9781 5 collections collection NNS cord-010119-t1x9gknd 9781 6 increased increase VBD cord-010119-t1x9gknd 9781 7 significantly significantly RB cord-010119-t1x9gknd 9781 8 year year NN cord-010119-t1x9gknd 9781 9 by by IN cord-010119-t1x9gknd 9781 10 year year NN cord-010119-t1x9gknd 9781 11 , , , cord-010119-t1x9gknd 9781 12 however however RB cord-010119-t1x9gknd 9781 13 , , , cord-010119-t1x9gknd 9781 14 data datum NNS cord-010119-t1x9gknd 9781 15 on on IN cord-010119-t1x9gknd 9781 16 hepatitis hepatitis NN cord-010119-t1x9gknd 9781 17 B B NNP cord-010119-t1x9gknd 9781 18 virus virus NN cord-010119-t1x9gknd 9781 19 marker marker NN cord-010119-t1x9gknd 9781 20 rates rate NNS cord-010119-t1x9gknd 9781 21 among among IN cord-010119-t1x9gknd 9781 22 these these DT cord-010119-t1x9gknd 9781 23 donors donor NNS cord-010119-t1x9gknd 9781 24 continue continue VBP cord-010119-t1x9gknd 9781 25 to to TO cord-010119-t1x9gknd 9781 26 be be VB cord-010119-t1x9gknd 9781 27 lacking lack VBG cord-010119-t1x9gknd 9781 28 . . . cord-010119-t1x9gknd 9782 1 The the DT cord-010119-t1x9gknd 9782 2 aim aim NN cord-010119-t1x9gknd 9782 3 of of IN cord-010119-t1x9gknd 9782 4 this this DT cord-010119-t1x9gknd 9782 5 study study NN cord-010119-t1x9gknd 9782 6 is be VBZ cord-010119-t1x9gknd 9782 7 to to TO cord-010119-t1x9gknd 9782 8 evaluate evaluate VB cord-010119-t1x9gknd 9782 9 the the DT cord-010119-t1x9gknd 9782 10 epidemic epidemic NN cord-010119-t1x9gknd 9782 11 characteristics characteristic NNS cord-010119-t1x9gknd 9782 12 , , , cord-010119-t1x9gknd 9782 13 incidence incidence NN cord-010119-t1x9gknd 9782 14 and and CC cord-010119-t1x9gknd 9782 15 estimate estimate VB cord-010119-t1x9gknd 9782 16 the the DT cord-010119-t1x9gknd 9782 17 risk risk NN cord-010119-t1x9gknd 9782 18 factors factor NNS cord-010119-t1x9gknd 9782 19 of of IN cord-010119-t1x9gknd 9782 20 OBI OBI NNP cord-010119-t1x9gknd 9782 21 among among IN cord-010119-t1x9gknd 9782 22 apheresis apheresis NN cord-010119-t1x9gknd 9782 23 donors donor NNS cord-010119-t1x9gknd 9782 24 in in IN cord-010119-t1x9gknd 9782 25 a a DT cord-010119-t1x9gknd 9782 26 region region NN cord-010119-t1x9gknd 9782 27 of of IN cord-010119-t1x9gknd 9782 28 central central JJ cord-010119-t1x9gknd 9782 29 China China NNP cord-010119-t1x9gknd 9782 30 . . . cord-010119-t1x9gknd 9783 1 Study Study NNP cord-010119-t1x9gknd 9783 2 Design Design NNP cord-010119-t1x9gknd 9783 3 / / SYM cord-010119-t1x9gknd 9783 4 Method method NN cord-010119-t1x9gknd 9783 5 : : : cord-010119-t1x9gknd 9783 6 Apheresis Apheresis NNP cord-010119-t1x9gknd 9783 7 donors donor NNS cord-010119-t1x9gknd 9783 8 ' ' POS cord-010119-t1x9gknd 9783 9 data datum NNS cord-010119-t1x9gknd 9783 10 from from IN cord-010119-t1x9gknd 9783 11 May May NNP cord-010119-t1x9gknd 9783 12 2015 2015 CD cord-010119-t1x9gknd 9783 13 to to IN cord-010119-t1x9gknd 9783 14 Dec Dec NNP cord-010119-t1x9gknd 9783 15 2016 2016 CD cord-010119-t1x9gknd 9783 16 was be VBD cord-010119-t1x9gknd 9783 17 retrospectively retrospectively RB cord-010119-t1x9gknd 9783 18 analyzed analyze VBN cord-010119-t1x9gknd 9783 19 . . . cord-010119-t1x9gknd 9784 1 All all DT cord-010119-t1x9gknd 9784 2 samples sample NNS cord-010119-t1x9gknd 9784 3 were be VBD cord-010119-t1x9gknd 9784 4 tested test VBN cord-010119-t1x9gknd 9784 5 for for IN cord-010119-t1x9gknd 9784 6 HBsAg hbsag ADD cord-010119-t1x9gknd 9784 7 , , , cord-010119-t1x9gknd 9784 8 HBV HBV NNP cord-010119-t1x9gknd 9784 9 DNA DNA NNP cord-010119-t1x9gknd 9784 10 , , , cord-010119-t1x9gknd 9784 11 and and CC cord-010119-t1x9gknd 9784 12 other other JJ cord-010119-t1x9gknd 9784 13 markers marker NNS cord-010119-t1x9gknd 9784 14 . . . cord-010119-t1x9gknd 9785 1 Nucleic nucleic JJ cord-010119-t1x9gknd 9785 2 acids acid NNS cord-010119-t1x9gknd 9785 3 testing test VBG cord-010119-t1x9gknd 9785 4 ( ( -LRB- cord-010119-t1x9gknd 9785 5 NAT NAT NNP cord-010119-t1x9gknd 9785 6 ) ) -RRB- cord-010119-t1x9gknd 9785 7 was be VBD cord-010119-t1x9gknd 9785 8 performed perform VBN cord-010119-t1x9gknd 9785 9 on on IN cord-010119-t1x9gknd 9785 10 the the DT cord-010119-t1x9gknd 9785 11 Roche Roche NNP cord-010119-t1x9gknd 9785 12 cobas cobas NNP cord-010119-t1x9gknd 9785 13 s201 s201 VBZ cord-010119-t1x9gknd 9785 14 platform platform NN cord-010119-t1x9gknd 9785 15 using use VBG cord-010119-t1x9gknd 9785 16 pools pool NNS cord-010119-t1x9gknd 9785 17 of of IN cord-010119-t1x9gknd 9785 18 6 6 CD cord-010119-t1x9gknd 9785 19 serologically serologically RB cord-010119-t1x9gknd 9785 20 negative negative JJ cord-010119-t1x9gknd 9785 21 samples sample NNS cord-010119-t1x9gknd 9785 22 and and CC cord-010119-t1x9gknd 9785 23 any any DT cord-010119-t1x9gknd 9785 24 pools pool NNS cord-010119-t1x9gknd 9785 25 positive positive JJ cord-010119-t1x9gknd 9785 26 would would MD cord-010119-t1x9gknd 9785 27 undergo undergo VB cord-010119-t1x9gknd 9785 28 NAT NAT NNP cord-010119-t1x9gknd 9785 29 again again RB cord-010119-t1x9gknd 9785 30 individually individually RB cord-010119-t1x9gknd 9785 31 . . . cord-010119-t1x9gknd 9786 1 HBsAg HBsAg NNP cord-010119-t1x9gknd 9786 2 negative negative JJ cord-010119-t1x9gknd 9786 3 , , , cord-010119-t1x9gknd 9786 4 but but CC cord-010119-t1x9gknd 9786 5 HBV HBV NNP cord-010119-t1x9gknd 9786 6 DNA DNA NNP cord-010119-t1x9gknd 9786 7 positive positive JJ cord-010119-t1x9gknd 9786 8 were be VBD cord-010119-t1x9gknd 9786 9 further further RB cord-010119-t1x9gknd 9786 10 tested test VBN cord-010119-t1x9gknd 9786 11 for for IN cord-010119-t1x9gknd 9786 12 HBV HBV NNP cord-010119-t1x9gknd 9786 13 DNA DNA NNP cord-010119-t1x9gknd 9786 14 quantitative quantitative JJ cord-010119-t1x9gknd 9786 15 PCR pcr NN cord-010119-t1x9gknd 9786 16 , , , cord-010119-t1x9gknd 9786 17 antibody antibody NN cord-010119-t1x9gknd 9786 18 to to IN cord-010119-t1x9gknd 9786 19 hepatitis hepatitis NNP cord-010119-t1x9gknd 9786 20 B B NNP cord-010119-t1x9gknd 9786 21 surface surface NN cord-010119-t1x9gknd 9786 22 antigen antigen NN cord-010119-t1x9gknd 9786 23 ( ( -LRB- cord-010119-t1x9gknd 9786 24 HBsAb hbsab CD cord-010119-t1x9gknd 9786 25 ) ) -RRB- cord-010119-t1x9gknd 9786 26 , , , cord-010119-t1x9gknd 9786 27 antibody antibody NN cord-010119-t1x9gknd 9786 28 to to IN cord-010119-t1x9gknd 9787 1 hepatitis hepatitis NNP cord-010119-t1x9gknd 9787 2 B B NNP cord-010119-t1x9gknd 9787 3 core core NN cord-010119-t1x9gknd 9787 4 antigen antigen NN cord-010119-t1x9gknd 9787 5 ( ( -LRB- cord-010119-t1x9gknd 9787 6 HBcAb hbcab CD cord-010119-t1x9gknd 9787 7 ) ) -RRB- cord-010119-t1x9gknd 9787 8 , , , cord-010119-t1x9gknd 9787 9 hepatitis hepatitis NN cord-010119-t1x9gknd 9787 10 B b NN cord-010119-t1x9gknd 9787 11 e e NN cord-010119-t1x9gknd 9787 12 antigen antigen NN cord-010119-t1x9gknd 9787 13 ( ( -LRB- cord-010119-t1x9gknd 9787 14 HBeAg hbeag CD cord-010119-t1x9gknd 9787 15 ) ) -RRB- cord-010119-t1x9gknd 9787 16 and and CC cord-010119-t1x9gknd 9787 17 antibody antibody NN cord-010119-t1x9gknd 9787 18 to to IN cord-010119-t1x9gknd 9787 19 hepatitis hepatitis NNP cord-010119-t1x9gknd 9787 20 B B NNP cord-010119-t1x9gknd 9787 21 e e NN cord-010119-t1x9gknd 9787 22 ( ( -LRB- cord-010119-t1x9gknd 9787 23 HBeAb hbeab CD cord-010119-t1x9gknd 9787 24 ) ) -RRB- cord-010119-t1x9gknd 9787 25 . . . cord-010119-t1x9gknd 9788 1 Results/ Results/ . cord-010119-t1x9gknd 9789 1 Finding finding NN cord-010119-t1x9gknd 9789 2 : : : cord-010119-t1x9gknd 9790 1 In in IN cord-010119-t1x9gknd 9790 2 the the DT cord-010119-t1x9gknd 9790 3 evaluation evaluation NN cord-010119-t1x9gknd 9790 4 , , , cord-010119-t1x9gknd 9790 5 68547 68547 CD cord-010119-t1x9gknd 9790 6 seronegative seronegative JJ cord-010119-t1x9gknd 9790 7 donations donation NNS cord-010119-t1x9gknd 9790 8 were be VBD cord-010119-t1x9gknd 9790 9 screened screen VBN cord-010119-t1x9gknd 9790 10 by by IN cord-010119-t1x9gknd 9790 11 NAT NAT NNP cord-010119-t1x9gknd 9790 12 and and CC cord-010119-t1x9gknd 9790 13 a a DT cord-010119-t1x9gknd 9790 14 total total NN cord-010119-t1x9gknd 9790 15 of of IN cord-010119-t1x9gknd 9790 16 20 20 CD cord-010119-t1x9gknd 9790 17 HBV HBV NNP cord-010119-t1x9gknd 9790 18 DNA dna NN cord-010119-t1x9gknd 9790 19 - - HYPH cord-010119-t1x9gknd 9790 20 reactive reactive JJ cord-010119-t1x9gknd 9790 21 / / SYM cord-010119-t1x9gknd 9790 22 HBsAg hbsag CD cord-010119-t1x9gknd 9790 23 - - HYPH cord-010119-t1x9gknd 9790 24 negative negative JJ cord-010119-t1x9gknd 9790 25 donors donor NNS cord-010119-t1x9gknd 9790 26 were be VBD cord-010119-t1x9gknd 9790 27 detected detect VBN cord-010119-t1x9gknd 9790 28 . . . cord-010119-t1x9gknd 9791 1 No no DT cord-010119-t1x9gknd 9791 2 HIV HIV NNP cord-010119-t1x9gknd 9791 3 RNA RNA NNP cord-010119-t1x9gknd 9791 4 -reactive -reactive : cord-010119-t1x9gknd 9791 5 or or CC cord-010119-t1x9gknd 9791 6 HCV HCV NNP cord-010119-t1x9gknd 9791 7 RNA RNA NNP cord-010119-t1x9gknd 9791 8 -reactive -reactive JJ cord-010119-t1x9gknd 9791 9 sample sample NN cord-010119-t1x9gknd 9791 10 was be VBD cord-010119-t1x9gknd 9791 11 detected detect VBN cord-010119-t1x9gknd 9791 12 . . . cord-010119-t1x9gknd 9792 1 Complete complete JJ cord-010119-t1x9gknd 9792 2 serologic serologic NN cord-010119-t1x9gknd 9792 3 screening screening NN cord-010119-t1x9gknd 9792 4 of of IN cord-010119-t1x9gknd 9792 5 the the DT cord-010119-t1x9gknd 9792 6 index index NN cord-010119-t1x9gknd 9792 7 donations donation NNS cord-010119-t1x9gknd 9792 8 indicated indicate VBD cord-010119-t1x9gknd 9792 9 that that IN cord-010119-t1x9gknd 9792 10 the the DT cord-010119-t1x9gknd 9792 11 majority majority NN cord-010119-t1x9gknd 9792 12 of of IN cord-010119-t1x9gknd 9792 13 these these DT cord-010119-t1x9gknd 9792 14 donors donor NNS cord-010119-t1x9gknd 9792 15 had have VBD cord-010119-t1x9gknd 9792 16 an an DT cord-010119-t1x9gknd 9792 17 occult occult JJ cord-010119-t1x9gknd 9792 18 HBV HBV NNP cord-010119-t1x9gknd 9792 19 infection infection NN cord-010119-t1x9gknd 9792 20 and and CC cord-010119-t1x9gknd 9792 21 the the DT cord-010119-t1x9gknd 9792 22 majority majority NN cord-010119-t1x9gknd 9792 23 of of IN cord-010119-t1x9gknd 9792 24 which which WDT cord-010119-t1x9gknd 9792 25 were be VBD cord-010119-t1x9gknd 9792 26 married married JJ cord-010119-t1x9gknd 9792 27 men man NNS cord-010119-t1x9gknd 9792 28 and and CC cord-010119-t1x9gknd 9792 29 the the DT cord-010119-t1x9gknd 9792 30 fixed fix VBN cord-010119-t1x9gknd 9792 31 donors donor NNS cord-010119-t1x9gknd 9792 32 with with IN cord-010119-t1x9gknd 9792 33 many many JJ cord-010119-t1x9gknd 9792 34 whole whole JJ cord-010119-t1x9gknd 9792 35 blood blood NN cord-010119-t1x9gknd 9792 36 or or CC cord-010119-t1x9gknd 9792 37 apheresis apheresis NN cord-010119-t1x9gknd 9792 38 donations donation NNS cord-010119-t1x9gknd 9792 39 . . . cord-010119-t1x9gknd 9793 1 Age age NN cord-010119-t1x9gknd 9793 2 distribution distribution NN cord-010119-t1x9gknd 9793 3 of of IN cord-010119-t1x9gknd 9793 4 the the DT cord-010119-t1x9gknd 9793 5 age age NN cord-010119-t1x9gknd 9793 6 group group NN cord-010119-t1x9gknd 9793 7 31 31 CD cord-010119-t1x9gknd 9793 8 - - SYM cord-010119-t1x9gknd 9793 9 55 55 CD cord-010119-t1x9gknd 9793 10 years year NNS cord-010119-t1x9gknd 9793 11 old old JJ cord-010119-t1x9gknd 9793 12 showed show VBD cord-010119-t1x9gknd 9793 13 a a DT cord-010119-t1x9gknd 9793 14 large large JJ cord-010119-t1x9gknd 9793 15 proportion proportion NN cord-010119-t1x9gknd 9793 16 , , , cord-010119-t1x9gknd 9793 17 who who WP cord-010119-t1x9gknd 9793 18 accounted account VBD cord-010119-t1x9gknd 9793 19 for for IN cord-010119-t1x9gknd 9793 20 80 80 CD cord-010119-t1x9gknd 9793 21 % % NN cord-010119-t1x9gknd 9793 22 of of IN cord-010119-t1x9gknd 9793 23 reported report VBN cord-010119-t1x9gknd 9793 24 infections infection NNS cord-010119-t1x9gknd 9793 25 . . . cord-010119-t1x9gknd 9794 1 Most Most JJS cord-010119-t1x9gknd 9794 2 of of IN cord-010119-t1x9gknd 9794 3 the the DT cord-010119-t1x9gknd 9794 4 HBV HBV NNP cord-010119-t1x9gknd 9794 5 DNA DNA NNP cord-010119-t1x9gknd 9794 6 cases case NNS cord-010119-t1x9gknd 9794 7 ( ( -LRB- cord-010119-t1x9gknd 9794 8 about about RB cord-010119-t1x9gknd 9794 9 80.0 80.0 CD cord-010119-t1x9gknd 9794 10 % % NN cord-010119-t1x9gknd 9794 11 ) ) -RRB- cord-010119-t1x9gknd 9794 12 reached reach VBD cord-010119-t1x9gknd 9794 13 senior senior JJ cord-010119-t1x9gknd 9794 14 high high JJ cord-010119-t1x9gknd 9794 15 school school NN cord-010119-t1x9gknd 9794 16 education education NN cord-010119-t1x9gknd 9794 17 . . . cord-010119-t1x9gknd 9795 1 The the DT cord-010119-t1x9gknd 9795 2 average average JJ cord-010119-t1x9gknd 9795 3 HBsAg hbsag ADD cord-010119-t1x9gknd 9795 4 DNA dna NN cord-010119-t1x9gknd 9795 5 positive positive JJ cord-010119-t1x9gknd 9795 6 rate rate NN cord-010119-t1x9gknd 9795 7 was be VBD cord-010119-t1x9gknd 9795 8 0.029 0.029 CD cord-010119-t1x9gknd 9795 9 % % NN cord-010119-t1x9gknd 9795 10 ( ( -LRB- cord-010119-t1x9gknd 9795 11 20/ 20/ CD cord-010119-t1x9gknd 9795 12 68547 68547 CD cord-010119-t1x9gknd 9795 13 ) ) -RRB- cord-010119-t1x9gknd 9795 14 . . . cord-010119-t1x9gknd 9796 1 Incidence incidence NN cord-010119-t1x9gknd 9796 2 among among IN cord-010119-t1x9gknd 9796 3 apheresis apheresis NN cord-010119-t1x9gknd 9796 4 donors donor NNS cord-010119-t1x9gknd 9796 5 in in IN cord-010119-t1x9gknd 9796 6 this this DT cord-010119-t1x9gknd 9796 7 period period NN cord-010119-t1x9gknd 9796 8 for for IN cord-010119-t1x9gknd 9797 1 HBsAg hbsag ADD cord-010119-t1x9gknd 9798 1 DNA DNA NNP cord-010119-t1x9gknd 9798 2 were be VBD cord-010119-t1x9gknd 9798 3 2.91/10000 2.91/10000 CD cord-010119-t1x9gknd 9798 4 . . . cord-010119-t1x9gknd 9799 1 These these DT cord-010119-t1x9gknd 9799 2 estimates estimate NNS cord-010119-t1x9gknd 9799 3 were be VBD cord-010119-t1x9gknd 9799 4 comparable comparable JJ cord-010119-t1x9gknd 9799 5 to to IN cord-010119-t1x9gknd 9799 6 those those DT cord-010119-t1x9gknd 9799 7 among among IN cord-010119-t1x9gknd 9799 8 repeat repeat VB cord-010119-t1x9gknd 9799 9 whole whole JJ cord-010119-t1x9gknd 9799 10 blood blood NN cord-010119-t1x9gknd 9799 11 donors donor NNS cord-010119-t1x9gknd 9799 12 . . . cord-010119-t1x9gknd 9800 1 We -PRON- PRP cord-010119-t1x9gknd 9800 2 developed develop VBD cord-010119-t1x9gknd 9800 3 pathogen pathogen NN cord-010119-t1x9gknd 9800 4 reduced reduce VBN cord-010119-t1x9gknd 9800 5 ( ( -LRB- cord-010119-t1x9gknd 9800 6 PR PR NNP cord-010119-t1x9gknd 9800 7 ) ) -RRB- cord-010119-t1x9gknd 9800 8 cryo cryo NN cord-010119-t1x9gknd 9800 9 derived derive VBN cord-010119-t1x9gknd 9800 10 from from IN cord-010119-t1x9gknd 9800 11 FFP FFP NNP cord-010119-t1x9gknd 9800 12 and and CC cord-010119-t1x9gknd 9800 13 PF24 PF24 NNP cord-010119-t1x9gknd 9800 14 with with IN cord-010119-t1x9gknd 9800 15 5 5 CD cord-010119-t1x9gknd 9800 16 day day NN cord-010119-t1x9gknd 9800 17 stability stability NN cord-010119-t1x9gknd 9800 18 at at IN cord-010119-t1x9gknd 9800 19 228C. 228C. NNP cord-010119-t1x9gknd 9800 20 Study Study NNP cord-010119-t1x9gknd 9800 21 Design Design NNP cord-010119-t1x9gknd 9800 22 / / SYM cord-010119-t1x9gknd 9800 23 Method method NN cord-010119-t1x9gknd 9800 24 : : : cord-010119-t1x9gknd 9801 1 Six six CD cord-010119-t1x9gknd 9801 2 replicates replicate NNS cord-010119-t1x9gknd 9801 3 of of IN cord-010119-t1x9gknd 9801 4 type type NN cord-010119-t1x9gknd 9801 5 - - HYPH cord-010119-t1x9gknd 9801 6 matched match VBN cord-010119-t1x9gknd 9801 7 pools pool NNS cord-010119-t1x9gknd 9801 8 of of IN cord-010119-t1x9gknd 9801 9 whole whole JJ cord-010119-t1x9gknd 9801 10 blood blood NN cord-010119-t1x9gknd 9801 11 derived derive VBN cord-010119-t1x9gknd 9801 12 ( ( -LRB- cord-010119-t1x9gknd 9801 13 WBD WBD NNP cord-010119-t1x9gknd 9801 14 ) ) -RRB- cord-010119-t1x9gknd 9801 15 and and CC cord-010119-t1x9gknd 9801 16 Apheresis Apheresis NNP cord-010119-t1x9gknd 9801 17 ( ( -LRB- cord-010119-t1x9gknd 9801 18 Aph Aph NNP cord-010119-t1x9gknd 9801 19 ) ) -RRB- cord-010119-t1x9gknd 9801 20 plasma plasma NN cord-010119-t1x9gknd 9801 21 were be VBD cord-010119-t1x9gknd 9801 22 split split VBN cord-010119-t1x9gknd 9801 23 to to TO cord-010119-t1x9gknd 9801 24 produce produce VB cord-010119-t1x9gknd 9801 25 conventional conventional JJ cord-010119-t1x9gknd 9801 26 control control NN cord-010119-t1x9gknd 9801 27 ( ( -LRB- cord-010119-t1x9gknd 9801 28 225 225 CD cord-010119-t1x9gknd 9801 29 610 610 CD cord-010119-t1x9gknd 9801 30 mL ml NN cord-010119-t1x9gknd 9801 31 ) ) -RRB- cord-010119-t1x9gknd 9801 32 and and CC cord-010119-t1x9gknd 9801 33 test test NN cord-010119-t1x9gknd 9801 34 components component NNS cord-010119-t1x9gknd 9801 35 ( ( -LRB- cord-010119-t1x9gknd 9801 36 625 625 CD cord-010119-t1x9gknd 9801 37 mL ml NN cord-010119-t1x9gknd 9801 38 625 625 CD cord-010119-t1x9gknd 9801 39 mL ml NN cord-010119-t1x9gknd 9801 40 ) ) -RRB- cord-010119-t1x9gknd 9801 41 . . . cord-010119-t1x9gknd 9802 1 Test test NN cord-010119-t1x9gknd 9802 2 components component NNS cord-010119-t1x9gknd 9802 3 were be VBD cord-010119-t1x9gknd 9802 4 PR PR NNP cord-010119-t1x9gknd 9802 5 with with IN cord-010119-t1x9gknd 9802 6 amotosalen amotosalen NN cord-010119-t1x9gknd 9802 7 and and CC cord-010119-t1x9gknd 9802 8 UVA UVA NNP cord-010119-t1x9gknd 9802 9 light light NN cord-010119-t1x9gknd 9802 10 . . . cord-010119-t1x9gknd 9803 1 Aph Aph NNP cord-010119-t1x9gknd 9803 2 and and CC cord-010119-t1x9gknd 9803 3 WBD WBD NNP cord-010119-t1x9gknd 9803 4 FFP FFP NNP cord-010119-t1x9gknd 9803 5 were be VBD cord-010119-t1x9gknd 9803 6 produced produce VBN cord-010119-t1x9gknd 9803 7 by by IN cord-010119-t1x9gknd 9803 8 freezing freeze VBG cord-010119-t1x9gknd 9803 9 plasma plasma NN cord-010119-t1x9gknd 9803 10 within within IN cord-010119-t1x9gknd 9803 11 8 8 CD cord-010119-t1x9gknd 9803 12 hr hr NN cord-010119-t1x9gknd 9803 13 and and CC cord-010119-t1x9gknd 9803 14 WBD WBD NNP cord-010119-t1x9gknd 9803 15 PF24 PF24 NNP cord-010119-t1x9gknd 9803 16 within within IN cord-010119-t1x9gknd 9803 17 24 24 CD cord-010119-t1x9gknd 9803 18 hr hr NN cord-010119-t1x9gknd 9803 19 . . . cord-010119-t1x9gknd 9804 1 Cryo Cryo NNP cord-010119-t1x9gknd 9804 2 was be VBD cord-010119-t1x9gknd 9804 3 manufactured manufacture VBN cord-010119-t1x9gknd 9804 4 according accord VBG cord-010119-t1x9gknd 9804 5 to to IN cord-010119-t1x9gknd 9804 6 site site NN cord-010119-t1x9gknd 9804 7 SOPs sop NNS cord-010119-t1x9gknd 9804 8 and and CC cord-010119-t1x9gknd 9804 9 frozen freeze VBN cord-010119-t1x9gknd 9804 10 at at IN cord-010119-t1x9gknd 9804 11 -308C -308C NNP cord-010119-t1x9gknd 9805 1 ( ( -LRB- cord-010119-t1x9gknd 9805 2 Test test NN cord-010119-t1x9gknd 9805 3 62 62 CD cord-010119-t1x9gknd 9805 4 6 6 CD cord-010119-t1x9gknd 9805 5 2 2 CD cord-010119-t1x9gknd 9805 6 mL ml NN cord-010119-t1x9gknd 9805 7 , , , cord-010119-t1x9gknd 9805 8 Control Control NNP cord-010119-t1x9gknd 9805 9 22 22 CD cord-010119-t1x9gknd 9805 10 6 6 CD cord-010119-t1x9gknd 9805 11 2 2 CD cord-010119-t1x9gknd 9805 12 mL ml NN cord-010119-t1x9gknd 9805 13 ) ) -RRB- cord-010119-t1x9gknd 9805 14 . . . cord-010119-t1x9gknd 9806 1 Test test VB cord-010119-t1x9gknd 9806 2 and and CC cord-010119-t1x9gknd 9806 3 Control Control NNP cord-010119-t1x9gknd 9806 4 Cryos Cryos NNP cord-010119-t1x9gknd 9806 5 were be VBD cord-010119-t1x9gknd 9806 6 thawed thaw VBN cord-010119-t1x9gknd 9806 7 at at IN cord-010119-t1x9gknd 9806 8 378C 378c CD cord-010119-t1x9gknd 9806 9 , , , cord-010119-t1x9gknd 9806 10 and and CC cord-010119-t1x9gknd 9806 11 characterized characterize VBN cord-010119-t1x9gknd 9807 1 immediately immediately RB cord-010119-t1x9gknd 9807 2 post post NN cord-010119-t1x9gknd 9807 3 thaw thaw NN cord-010119-t1x9gknd 9807 4 ( ( -LRB- cord-010119-t1x9gknd 9807 5 t50 t50 NNP cord-010119-t1x9gknd 9807 6 ) ) -RRB- cord-010119-t1x9gknd 9807 7 , , , cord-010119-t1x9gknd 9807 8 and and CC cord-010119-t1x9gknd 9807 9 after after IN cord-010119-t1x9gknd 9807 10 5 5 CD cord-010119-t1x9gknd 9807 11 d d NN cord-010119-t1x9gknd 9807 12 storage storage NN cord-010119-t1x9gknd 9807 13 at at IN cord-010119-t1x9gknd 9807 14 228C 228c CD cord-010119-t1x9gknd 9807 15 and and CC cord-010119-t1x9gknd 9807 16 tested test VBN cord-010119-t1x9gknd 9807 17 for for IN cord-010119-t1x9gknd 9807 18 FB fb NN cord-010119-t1x9gknd 9807 19 and and CC cord-010119-t1x9gknd 9807 20 FVIII FVIII NNP cord-010119-t1x9gknd 9807 21 function function NN cord-010119-t1x9gknd 9807 22 , , , cord-010119-t1x9gknd 9807 23 thromboelastography thromboelastography NNP cord-010119-t1x9gknd 9807 24 ( ( -LRB- cord-010119-t1x9gknd 9807 25 ROTEM ROTEM NNP cord-010119-t1x9gknd 9807 26 ) ) -RRB- cord-010119-t1x9gknd 9807 27 and and CC cord-010119-t1x9gknd 9807 28 thrombin thrombin JJ cord-010119-t1x9gknd 9807 29 generation generation NN cord-010119-t1x9gknd 9807 30 ( ( -LRB- cord-010119-t1x9gknd 9807 31 CAT cat NN cord-010119-t1x9gknd 9807 32 ) ) -RRB- cord-010119-t1x9gknd 9807 33 . . . cord-010119-t1x9gknd 9808 1 Results/ Results/ . cord-010119-t1x9gknd 9809 1 Finding finding NN cord-010119-t1x9gknd 9809 2 : : : cord-010119-t1x9gknd 9810 1 PR PR NNP cord-010119-t1x9gknd 9810 2 cryo cryo NN cord-010119-t1x9gknd 9810 3 retained retain VBD cord-010119-t1x9gknd 9810 4 sufficient sufficient JJ cord-010119-t1x9gknd 9810 5 FB fb NN cord-010119-t1x9gknd 9810 6 and and CC cord-010119-t1x9gknd 9810 7 FVIII FVIII NNP cord-010119-t1x9gknd 9810 8 activity activity NN cord-010119-t1x9gknd 9810 9 post post NN cord-010119-t1x9gknd 9810 10 thaw thaw NN cord-010119-t1x9gknd 9810 11 and and CC cord-010119-t1x9gknd 9811 1 over over IN cord-010119-t1x9gknd 9811 2 5d 5d CD cord-010119-t1x9gknd 9811 3 at at IN cord-010119-t1x9gknd 9811 4 228C 228c CD cord-010119-t1x9gknd 9811 5 ( ( -LRB- cord-010119-t1x9gknd 9811 6 Table table NN cord-010119-t1x9gknd 9811 7 ) ) -RRB- cord-010119-t1x9gknd 9811 8 for for IN cord-010119-t1x9gknd 9811 9 hemostatic hemostatic JJ cord-010119-t1x9gknd 9811 10 capacity capacity NN cord-010119-t1x9gknd 9811 11 . . . cord-010119-t1x9gknd 9812 1 ROTEM ROTEM NNP cord-010119-t1x9gknd 9812 2 ( ( -LRB- cord-010119-t1x9gknd 9812 3 EXTEM EXTEM NNP cord-010119-t1x9gknd 9812 4 ) ) -RRB- cord-010119-t1x9gknd 9812 5 showed show VBD cord-010119-t1x9gknd 9812 6 retention retention NN cord-010119-t1x9gknd 9812 7 of of IN cord-010119-t1x9gknd 9812 8 fibrin fibrin NN cord-010119-t1x9gknd 9812 9 formation formation NN cord-010119-t1x9gknd 9812 10 ( ( -LRB- cord-010119-t1x9gknd 9812 11 a a DT cord-010119-t1x9gknd 9812 12 angle angle NN cord-010119-t1x9gknd 9812 13 ) ) -RRB- cord-010119-t1x9gknd 9812 14 and and CC cord-010119-t1x9gknd 9812 15 clot clot NN cord-010119-t1x9gknd 9812 16 quality quality NN cord-010119-t1x9gknd 9812 17 ( ( -LRB- cord-010119-t1x9gknd 9812 18 MCF MCF NNP cord-010119-t1x9gknd 9812 19 ) ) -RRB- cord-010119-t1x9gknd 9812 20 ( ( -LRB- cord-010119-t1x9gknd 9812 21 Table table NN cord-010119-t1x9gknd 9812 22 ) ) -RRB- cord-010119-t1x9gknd 9812 23 . . . cord-010119-t1x9gknd 9813 1 Thrombin Thrombin NNP cord-010119-t1x9gknd 9813 2 generation generation NN cord-010119-t1x9gknd 9813 3 was be VBD cord-010119-t1x9gknd 9813 4 robust robust JJ cord-010119-t1x9gknd 9813 5 as as IN cord-010119-t1x9gknd 9813 6 demonstrated demonstrate VBN cord-010119-t1x9gknd 9813 7 by by IN cord-010119-t1x9gknd 9813 8 multiple multiple JJ cord-010119-t1x9gknd 9813 9 parameters parameter NNS cord-010119-t1x9gknd 9813 10 ( ( -LRB- cord-010119-t1x9gknd 9813 11 lag lag VB cord-010119-t1x9gknd 9813 12 time time NN cord-010119-t1x9gknd 9813 13 , , , cord-010119-t1x9gknd 9814 1 peak peak NNP cord-010119-t1x9gknd 9814 2 thrombin thrombin NNP cord-010119-t1x9gknd 9814 3 , , , cord-010119-t1x9gknd 9814 4 endogenous endogenous JJ cord-010119-t1x9gknd 9814 5 total total JJ cord-010119-t1x9gknd 9814 6 thrombin thrombin NN cord-010119-t1x9gknd 9814 7 potential potential NN cord-010119-t1x9gknd 9814 8 ( ( -LRB- cord-010119-t1x9gknd 9814 9 ETP ETP NNP cord-010119-t1x9gknd 9814 10 ) ) -RRB- cord-010119-t1x9gknd 9814 11 , , , cord-010119-t1x9gknd 9814 12 and and CC cord-010119-t1x9gknd 9814 13 time time NN cord-010119-t1x9gknd 9814 14 to to TO cord-010119-t1x9gknd 9814 15 peak peak VB cord-010119-t1x9gknd 9814 16 ( ( -LRB- cord-010119-t1x9gknd 9814 17 tt tt NNP cord-010119-t1x9gknd 9814 18 ) ) -RRB- cord-010119-t1x9gknd 9814 19 despite despite IN cord-010119-t1x9gknd 9814 20 lower low JJR cord-010119-t1x9gknd 9814 21 FVIII FVIII NNP cord-010119-t1x9gknd 9814 22 levels level NNS cord-010119-t1x9gknd 9814 23 . . . cord-010119-t1x9gknd 9815 1 These these DT cord-010119-t1x9gknd 9815 2 parameters parameter NNS cord-010119-t1x9gknd 9815 3 were be VBD cord-010119-t1x9gknd 9815 4 maintained maintain VBN cord-010119-t1x9gknd 9815 5 through through IN cord-010119-t1x9gknd 9815 6 5d 5d CD cord-010119-t1x9gknd 9815 7 storage storage NN cord-010119-t1x9gknd 9815 8 at at IN cord-010119-t1x9gknd 9815 9 228C. 228C. NNP cord-010119-t1x9gknd 9815 10 Conclusion conclusion NN cord-010119-t1x9gknd 9815 11 : : : cord-010119-t1x9gknd 9815 12 PR PR NNP cord-010119-t1x9gknd 9815 13 cryo cryo NN cord-010119-t1x9gknd 9815 14 can can MD cord-010119-t1x9gknd 9815 15 be be VB cord-010119-t1x9gknd 9815 16 processed process VBN cord-010119-t1x9gknd 9815 17 from from IN cord-010119-t1x9gknd 9815 18 3 3 CD cord-010119-t1x9gknd 9815 19 plasma plasma NN cord-010119-t1x9gknd 9815 20 sources source NNS cord-010119-t1x9gknd 9815 21 , , , cord-010119-t1x9gknd 9815 22 including include VBG cord-010119-t1x9gknd 9815 23 PF24 PF24 NNP cord-010119-t1x9gknd 9815 24 , , , cord-010119-t1x9gknd 9815 25 and and CC cord-010119-t1x9gknd 9815 26 stored store VBN cord-010119-t1x9gknd 9815 27 at at IN cord-010119-t1x9gknd 9815 28 RT RT NNP cord-010119-t1x9gknd 9815 29 for for IN cord-010119-t1x9gknd 9815 30 5 5 CD cord-010119-t1x9gknd 9815 31 days day NNS cord-010119-t1x9gknd 9815 32 . . . cord-010119-t1x9gknd 9816 1 PR PR NNP cord-010119-t1x9gknd 9816 2 plasma plasma NN cord-010119-t1x9gknd 9816 3 provides provide VBZ cord-010119-t1x9gknd 9816 4 adequate adequate JJ cord-010119-t1x9gknd 9816 5 levels level NNS cord-010119-t1x9gknd 9816 6 of of IN cord-010119-t1x9gknd 9816 7 FB fb NN cord-010119-t1x9gknd 9816 8 with with IN cord-010119-t1x9gknd 9816 9 hemostatic hemostatic JJ cord-010119-t1x9gknd 9816 10 capacity capacity NN cord-010119-t1x9gknd 9816 11 equivalent equivalent JJ cord-010119-t1x9gknd 9816 12 to to TO cord-010119-t1x9gknd 9816 13 control control VB cord-010119-t1x9gknd 9816 14 as as IN cord-010119-t1x9gknd 9816 15 demonstrated demonstrate VBN cord-010119-t1x9gknd 9816 16 by by IN cord-010119-t1x9gknd 9816 17 ROTEM ROTEM NNP cord-010119-t1x9gknd 9816 18 and and CC cord-010119-t1x9gknd 9816 19 CAT cat NN cord-010119-t1x9gknd 9816 20 . . . cord-010119-t1x9gknd 9817 1 Use Use NNP cord-010119-t1x9gknd 9817 2 of of IN cord-010119-t1x9gknd 9817 3 PF24 PF24 NNP cord-010119-t1x9gknd 9817 4 with with IN cord-010119-t1x9gknd 9817 5 stability stability NN cord-010119-t1x9gknd 9817 6 over over IN cord-010119-t1x9gknd 9817 7 5 5 CD cord-010119-t1x9gknd 9817 8 days day NNS cord-010119-t1x9gknd 9817 9 can can MD cord-010119-t1x9gknd 9817 10 increase increase VB cord-010119-t1x9gknd 9817 11 the the DT cord-010119-t1x9gknd 9817 12 availability availability NN cord-010119-t1x9gknd 9817 13 of of IN cord-010119-t1x9gknd 9817 14 cryo cryo NN cord-010119-t1x9gknd 9817 15 with with IN cord-010119-t1x9gknd 9817 16 a a DT cord-010119-t1x9gknd 9817 17 reduced reduce VBN cord-010119-t1x9gknd 9817 18 risk risk NN cord-010119-t1x9gknd 9817 19 of of IN cord-010119-t1x9gknd 9817 20 transfusion transfusion NN cord-010119-t1x9gknd 9817 21 - - HYPH cord-010119-t1x9gknd 9817 22 transmitted transmit VBN cord-010119-t1x9gknd 9817 23 infection infection NN cord-010119-t1x9gknd 9817 24 . . . cord-010119-t1x9gknd 9818 1 Cryo cryo NN cord-010119-t1x9gknd 9818 2 produced produce VBN cord-010119-t1x9gknd 9818 3 with with IN cord-010119-t1x9gknd 9818 4 psoralen psoralen NN cord-010119-t1x9gknd 9818 5 - - HYPH cord-010119-t1x9gknd 9818 6 treated treat VBN cord-010119-t1x9gknd 9818 7 ( ( -LRB- cord-010119-t1x9gknd 9818 8 PR pr NN cord-010119-t1x9gknd 9818 9 ) ) -RRB- cord-010119-t1x9gknd 9818 10 plasma plasma NN cord-010119-t1x9gknd 9818 11 is be VBZ cord-010119-t1x9gknd 9818 12 not not RB cord-010119-t1x9gknd 9818 13 approved approve VBN cord-010119-t1x9gknd 9818 14 for for IN cord-010119-t1x9gknd 9818 15 use use NN cord-010119-t1x9gknd 9818 16 in in IN cord-010119-t1x9gknd 9818 17 the the DT cord-010119-t1x9gknd 9818 18 US US NNP cord-010119-t1x9gknd 9818 19 . . . cord-010119-t1x9gknd 9819 1 Performance performance NN cord-010119-t1x9gknd 9819 2 of of IN cord-010119-t1x9gknd 9819 3 a a DT cord-010119-t1x9gknd 9819 4 New New NNP cord-010119-t1x9gknd 9819 5 Automated Automated NNP cord-010119-t1x9gknd 9819 6 Alinity Alinity NNP cord-010119-t1x9gknd 9819 7 s s POS cord-010119-t1x9gknd 9819 8 Assay Assay NNP cord-010119-t1x9gknd 9819 9 for for IN cord-010119-t1x9gknd 9819 10 Antibodies antibody NNS cord-010119-t1x9gknd 9819 11 to to IN cord-010119-t1x9gknd 9819 12 T. T. NNP cord-010119-t1x9gknd 9819 13 Cruzi Cruzi NNP cord-010119-t1x9gknd 9819 14 Darwin Darwin NNP cord-010119-t1x9gknd 9819 15 Smith Smith NNP cord-010119-t1x9gknd 9819 16 * * NFP cord-010119-t1x9gknd 9819 17 1 1 CD cord-010119-t1x9gknd 9819 18 , , , cord-010119-t1x9gknd 9819 19 Ed Ed NNP cord-010119-t1x9gknd 9819 20 Bakker Bakker NNP cord-010119-t1x9gknd 9819 21 2 2 CD cord-010119-t1x9gknd 9819 22 , , , cord-010119-t1x9gknd 9819 23 Anton Anton NNP cord-010119-t1x9gknd 9819 24 van van NNP cord-010119-t1x9gknd 9819 25 Weert Weert NNP cord-010119-t1x9gknd 9819 26 2 2 CD cord-010119-t1x9gknd 9819 27 , , , cord-010119-t1x9gknd 9819 28 Jane Jane NNP cord-010119-t1x9gknd 9819 29 Bryant Bryant NNP cord-010119-t1x9gknd 9819 30 1 1 CD cord-010119-t1x9gknd 9819 31 , , , cord-010119-t1x9gknd 9819 32 Mark Mark NNP cord-010119-t1x9gknd 9819 33 Paradowski Paradowski NNP cord-010119-t1x9gknd 9819 34 1 1 CD cord-010119-t1x9gknd 9819 35 , , , cord-010119-t1x9gknd 9819 36 Lynne Lynne NNP cord-010119-t1x9gknd 9819 37 Fleischmann Fleischmann NNP cord-010119-t1x9gknd 9819 38 1 1 CD cord-010119-t1x9gknd 9819 39 , , , cord-010119-t1x9gknd 9819 40 Mirjana Mirjana NNP cord-010119-t1x9gknd 9819 41 Sarac Sarac NNP cord-010119-t1x9gknd 9819 42 3 3 CD cord-010119-t1x9gknd 9819 43 , , , cord-010119-t1x9gknd 9819 44 George George NNP cord-010119-t1x9gknd 9819 45 Chen Chen NNP cord-010119-t1x9gknd 9819 46 1 1 CD cord-010119-t1x9gknd 9819 47 , , , cord-010119-t1x9gknd 9819 48 George George NNP cord-010119-t1x9gknd 9819 49 Schlauder Schlauder NNP cord-010119-t1x9gknd 9819 50 1 1 CD cord-010119-t1x9gknd 9819 51 and and CC cord-010119-t1x9gknd 9819 52 Gregg Gregg NNP cord-010119-t1x9gknd 9819 53 Williams Williams NNP cord-010119-t1x9gknd 9819 54 1 1 CD cord-010119-t1x9gknd 9819 55 . . . cord-010119-t1x9gknd 9820 1 1 1 LS cord-010119-t1x9gknd 9820 2 Abbott Abbott NNP cord-010119-t1x9gknd 9820 3 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9820 4 , , , cord-010119-t1x9gknd 9820 5 2 2 CD cord-010119-t1x9gknd 9820 6 Sanquin Sanquin NNP cord-010119-t1x9gknd 9820 7 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9820 8 , , , cord-010119-t1x9gknd 9820 9 3 3 CD cord-010119-t1x9gknd 9820 10 Abbott Abbott NNP cord-010119-t1x9gknd 9820 11 GmbH GmbH NNP cord-010119-t1x9gknd 9820 12 & & CC cord-010119-t1x9gknd 9821 1 Co. Co. NNP cord-010119-t1x9gknd 9821 2 KG KG NNP cord-010119-t1x9gknd 9822 1 Background Background NNP cord-010119-t1x9gknd 9822 2 / / SYM cord-010119-t1x9gknd 9822 3 Case Case NNP cord-010119-t1x9gknd 9822 4 Studies Studies NNPS cord-010119-t1x9gknd 9822 5 : : : cord-010119-t1x9gknd 9823 1 The the DT cord-010119-t1x9gknd 9823 2 parasite parasite NN cord-010119-t1x9gknd 9823 3 , , , cord-010119-t1x9gknd 9823 4 Trypanosoma Trypanosoma NNP cord-010119-t1x9gknd 9823 5 cruzi cruzi NNP cord-010119-t1x9gknd 9823 6 ( ( -LRB- cord-010119-t1x9gknd 9823 7 T. T. NNP cord-010119-t1x9gknd 9823 8 cruzi cruzi NNP cord-010119-t1x9gknd 9823 9 ) ) -RRB- cord-010119-t1x9gknd 9823 10 , , , cord-010119-t1x9gknd 9823 11 is be VBZ cord-010119-t1x9gknd 9823 12 the the DT cord-010119-t1x9gknd 9823 13 cause cause NN cord-010119-t1x9gknd 9823 14 of of IN cord-010119-t1x9gknd 9823 15 Chagas Chagas NNP cord-010119-t1x9gknd 9823 16 disease disease NN cord-010119-t1x9gknd 9823 17 which which WDT cord-010119-t1x9gknd 9823 18 is be VBZ cord-010119-t1x9gknd 9823 19 endemic endemic JJ cord-010119-t1x9gknd 9823 20 to to IN cord-010119-t1x9gknd 9823 21 the the DT cord-010119-t1x9gknd 9823 22 Americas Americas NNPS cord-010119-t1x9gknd 9823 23 and and CC cord-010119-t1x9gknd 9823 24 infects infect VBZ cord-010119-t1x9gknd 9823 25 6 6 CD cord-010119-t1x9gknd 9823 26 - - SYM cord-010119-t1x9gknd 9823 27 8 8 CD cord-010119-t1x9gknd 9823 28 million million CD cord-010119-t1x9gknd 9823 29 people people NNS cord-010119-t1x9gknd 9823 30 . . . cord-010119-t1x9gknd 9824 1 In in IN cord-010119-t1x9gknd 9824 2 order order NN cord-010119-t1x9gknd 9824 3 to to TO cord-010119-t1x9gknd 9824 4 prevent prevent VB cord-010119-t1x9gknd 9824 5 transfusion transfusion NN cord-010119-t1x9gknd 9824 6 mediated mediate VBN cord-010119-t1x9gknd 9824 7 transmission transmission NN cord-010119-t1x9gknd 9824 8 of of IN cord-010119-t1x9gknd 9824 9 this this DT cord-010119-t1x9gknd 9824 10 parasite parasite NN cord-010119-t1x9gknd 9824 11 in in IN cord-010119-t1x9gknd 9824 12 endemic endemic JJ cord-010119-t1x9gknd 9824 13 countries country NNS cord-010119-t1x9gknd 9824 14 , , , cord-010119-t1x9gknd 9824 15 blood blood NN cord-010119-t1x9gknd 9824 16 collection collection NN cord-010119-t1x9gknd 9824 17 centers center NNS cord-010119-t1x9gknd 9824 18 require require VBP cord-010119-t1x9gknd 9824 19 high high JJ cord-010119-t1x9gknd 9824 20 throughput throughput NN cord-010119-t1x9gknd 9824 21 anti anti JJ cord-010119-t1x9gknd 9824 22 - - JJ cord-010119-t1x9gknd 9824 23 T. t. JJ cord-010119-t1x9gknd 9824 24 cruzi cruzi NN cord-010119-t1x9gknd 9824 25 assays assay NNS cord-010119-t1x9gknd 9824 26 with with IN cord-010119-t1x9gknd 9824 27 good good JJ cord-010119-t1x9gknd 9824 28 specificity specificity NN cord-010119-t1x9gknd 9824 29 and and CC cord-010119-t1x9gknd 9824 30 sensitivity sensitivity NN cord-010119-t1x9gknd 9824 31 . . . cord-010119-t1x9gknd 9825 1 In in IN cord-010119-t1x9gknd 9825 2 nonendemic nonendemic NNP cord-010119-t1x9gknd 9825 3 countries country NNS cord-010119-t1x9gknd 9825 4 , , , cord-010119-t1x9gknd 9825 5 selective selective JJ cord-010119-t1x9gknd 9825 6 testing testing NN cord-010119-t1x9gknd 9825 7 of of IN cord-010119-t1x9gknd 9825 8 at at IN cord-010119-t1x9gknd 9825 9 risk risk NN cord-010119-t1x9gknd 9825 10 donors donor NNS cord-010119-t1x9gknd 9825 11 is be VBZ cord-010119-t1x9gknd 9825 12 a a DT cord-010119-t1x9gknd 9825 13 strategy strategy NN cord-010119-t1x9gknd 9825 14 to to TO cord-010119-t1x9gknd 9825 15 avoid avoid VB cord-010119-t1x9gknd 9825 16 temporary temporary JJ cord-010119-t1x9gknd 9825 17 donor donor NN cord-010119-t1x9gknd 9825 18 deferrals deferral NNS cord-010119-t1x9gknd 9825 19 . . . cord-010119-t1x9gknd 9826 1 In in IN cord-010119-t1x9gknd 9826 2 addition addition NN cord-010119-t1x9gknd 9826 3 , , , cord-010119-t1x9gknd 9826 4 continued continue VBN cord-010119-t1x9gknd 9826 5 pressures pressure NNS cord-010119-t1x9gknd 9826 6 on on IN cord-010119-t1x9gknd 9826 7 laboratory laboratory NN cord-010119-t1x9gknd 9826 8 operations operation NNS cord-010119-t1x9gknd 9826 9 demand demand VBP cord-010119-t1x9gknd 9826 10 that that IN cord-010119-t1x9gknd 9826 11 assays assay NNS cord-010119-t1x9gknd 9826 12 perform perform VBP cord-010119-t1x9gknd 9826 13 on on IN cord-010119-t1x9gknd 9826 14 platforms platform NNS cord-010119-t1x9gknd 9826 15 capable capable JJ cord-010119-t1x9gknd 9826 16 of of IN cord-010119-t1x9gknd 9826 17 increased increase VBN cord-010119-t1x9gknd 9826 18 walk walk NN cord-010119-t1x9gknd 9826 19 away away RB cord-010119-t1x9gknd 9826 20 time time NN cord-010119-t1x9gknd 9826 21 and and CC cord-010119-t1x9gknd 9826 22 enhanced enhanced JJ cord-010119-t1x9gknd 9826 23 automation automation NN cord-010119-t1x9gknd 9826 24 in in IN cord-010119-t1x9gknd 9826 25 areas area NNS cord-010119-t1x9gknd 9826 26 of of IN cord-010119-t1x9gknd 9826 27 reagent reagent NN cord-010119-t1x9gknd 9826 28 management management NN cord-010119-t1x9gknd 9826 29 , , , cord-010119-t1x9gknd 9826 30 retest retest VB cord-010119-t1x9gknd 9826 31 options option NNS cord-010119-t1x9gknd 9826 32 , , , cord-010119-t1x9gknd 9826 33 and and CC cord-010119-t1x9gknd 9826 34 commodity commodity NN cord-010119-t1x9gknd 9826 35 / / SYM cord-010119-t1x9gknd 9826 36 waste waste NN cord-010119-t1x9gknd 9826 37 management management NN cord-010119-t1x9gknd 9826 38 . . . cord-010119-t1x9gknd 9827 1 Study Study NNP cord-010119-t1x9gknd 9827 2 Design Design NNP cord-010119-t1x9gknd 9827 3 / / SYM cord-010119-t1x9gknd 9827 4 Method method NN cord-010119-t1x9gknd 9827 5 : : : cord-010119-t1x9gknd 9828 1 The the DT cord-010119-t1x9gknd 9828 2 performance performance NN cord-010119-t1x9gknd 9828 3 of of IN cord-010119-t1x9gknd 9828 4 the the DT cord-010119-t1x9gknd 9828 5 new new JJ cord-010119-t1x9gknd 9828 6 automated automate VBN cord-010119-t1x9gknd 9828 7 chemiluminescence chemiluminescence NN cord-010119-t1x9gknd 9828 8 immunoassay immunoassay NN cord-010119-t1x9gknd 9828 9 for for IN cord-010119-t1x9gknd 9828 10 the the DT cord-010119-t1x9gknd 9828 11 detection detection NN cord-010119-t1x9gknd 9828 12 of of IN cord-010119-t1x9gknd 9828 13 antibodies antibody NNS cord-010119-t1x9gknd 9828 14 to to IN cord-010119-t1x9gknd 9828 15 T. T. NNP cord-010119-t1x9gknd 9828 16 cruzi cruzi NNP cord-010119-t1x9gknd 9828 17 was be VBD cord-010119-t1x9gknd 9828 18 evaluated evaluate VBN cord-010119-t1x9gknd 9828 19 on on IN cord-010119-t1x9gknd 9828 20 the the DT cord-010119-t1x9gknd 9828 21 Alinity Alinity NNP cord-010119-t1x9gknd 9828 22 s s POS cord-010119-t1x9gknd 9828 23 automated automate VBN cord-010119-t1x9gknd 9828 24 platform platform NN cord-010119-t1x9gknd 9828 25 and and CC cord-010119-t1x9gknd 9828 26 compared compare VBN cord-010119-t1x9gknd 9828 27 to to IN cord-010119-t1x9gknd 9828 28 another another DT cord-010119-t1x9gknd 9828 29 onmarket onmarket NN cord-010119-t1x9gknd 9828 30 chemiluminescent chemiluminescent NN cord-010119-t1x9gknd 9828 31 immunoassay immunoassay NN cord-010119-t1x9gknd 9828 32 . . . cord-010119-t1x9gknd 9829 1 Precision precision NN cord-010119-t1x9gknd 9829 2 was be VBD cord-010119-t1x9gknd 9829 3 assessed assess VBN cord-010119-t1x9gknd 9829 4 over over IN cord-010119-t1x9gknd 9829 5 20 20 CD cord-010119-t1x9gknd 9829 6 days day NNS cord-010119-t1x9gknd 9829 7 using use VBG cord-010119-t1x9gknd 9829 8 a a DT cord-010119-t1x9gknd 9829 9 panel panel NN cord-010119-t1x9gknd 9829 10 of of IN cord-010119-t1x9gknd 9829 11 positive positive JJ cord-010119-t1x9gknd 9829 12 and and CC cord-010119-t1x9gknd 9829 13 negative negative JJ cord-010119-t1x9gknd 9829 14 samples sample NNS cord-010119-t1x9gknd 9829 15 . . . cord-010119-t1x9gknd 9830 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9830 2 was be VBD cord-010119-t1x9gknd 9830 3 evaluated evaluate VBN cord-010119-t1x9gknd 9830 4 on on IN cord-010119-t1x9gknd 9830 5 407 407 CD cord-010119-t1x9gknd 9830 6 presumed presume VBN cord-010119-t1x9gknd 9830 7 antibody antibody NN cord-010119-t1x9gknd 9830 8 positive positive JJ cord-010119-t1x9gknd 9830 9 specimens specimen NNS cord-010119-t1x9gknd 9830 10 and and CC cord-010119-t1x9gknd 9830 11 specificity specificity NN cord-010119-t1x9gknd 9830 12 was be VBD cord-010119-t1x9gknd 9830 13 evaluated evaluate VBN cord-010119-t1x9gknd 9830 14 on on IN cord-010119-t1x9gknd 9830 15 7621 7621 CD cord-010119-t1x9gknd 9830 16 random random JJ cord-010119-t1x9gknd 9830 17 blood blood NN cord-010119-t1x9gknd 9830 18 donor donor NN cord-010119-t1x9gknd 9830 19 samples sample NNS cord-010119-t1x9gknd 9830 20 . . . cord-010119-t1x9gknd 9831 1 Results/ Results/ . cord-010119-t1x9gknd 9832 1 Finding finding NN cord-010119-t1x9gknd 9832 2 : : : cord-010119-t1x9gknd 9833 1 Precision precision NN cord-010119-t1x9gknd 9833 2 was be VBD cord-010119-t1x9gknd 9833 3 7 7 CD cord-010119-t1x9gknd 9833 4 % % NN cord-010119-t1x9gknd 9833 5 CV cv NN cord-010119-t1x9gknd 9833 6 or or CC cord-010119-t1x9gknd 9833 7 less less JJR cord-010119-t1x9gknd 9833 8 for for IN cord-010119-t1x9gknd 9833 9 positive positive JJ cord-010119-t1x9gknd 9833 10 samples sample NNS cord-010119-t1x9gknd 9833 11 over over IN cord-010119-t1x9gknd 9833 12 20 20 CD cord-010119-t1x9gknd 9833 13 days day NNS cord-010119-t1x9gknd 9833 14 . . . cord-010119-t1x9gknd 9834 1 The the DT cord-010119-t1x9gknd 9834 2 overall overall JJ cord-010119-t1x9gknd 9834 3 specificity specificity NN cord-010119-t1x9gknd 9834 4 in in IN cord-010119-t1x9gknd 9834 5 a a DT cord-010119-t1x9gknd 9834 6 blood blood NN cord-010119-t1x9gknd 9834 7 donor donor NN cord-010119-t1x9gknd 9834 8 population population NN cord-010119-t1x9gknd 9834 9 was be VBD cord-010119-t1x9gknd 9834 10 99.99 99.99 CD cord-010119-t1x9gknd 9834 11 % % NN cord-010119-t1x9gknd 9834 12 ( ( -LRB- cord-010119-t1x9gknd 9834 13 7620/ 7620/ CD cord-010119-t1x9gknd 9834 14 7621 7621 CD cord-010119-t1x9gknd 9834 15 ) ) -RRB- cord-010119-t1x9gknd 9834 16 . . . cord-010119-t1x9gknd 9835 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9835 2 was be VBD cord-010119-t1x9gknd 9835 3 100.00 100.00 CD cord-010119-t1x9gknd 9835 4 % % NN cord-010119-t1x9gknd 9835 5 for for IN cord-010119-t1x9gknd 9835 6 407 407 CD cord-010119-t1x9gknd 9835 7 presumed presume VBN cord-010119-t1x9gknd 9835 8 antibody antibody NN cord-010119-t1x9gknd 9835 9 positive positive JJ cord-010119-t1x9gknd 9835 10 samples sample NNS cord-010119-t1x9gknd 9835 11 . . . cord-010119-t1x9gknd 9836 1 Conclusion conclusion NN cord-010119-t1x9gknd 9836 2 : : : cord-010119-t1x9gknd 9837 1 These these DT cord-010119-t1x9gknd 9837 2 results result NNS cord-010119-t1x9gknd 9837 3 indicated indicate VBD cord-010119-t1x9gknd 9837 4 that that IN cord-010119-t1x9gknd 9837 5 the the DT cord-010119-t1x9gknd 9837 6 new new JJ cord-010119-t1x9gknd 9837 7 automated automate VBN cord-010119-t1x9gknd 9837 8 Alinity Alinity NNP cord-010119-t1x9gknd 9837 9 s s POS cord-010119-t1x9gknd 9837 10 Chagas Chagas NNP cord-010119-t1x9gknd 9837 11 assay assay NN cord-010119-t1x9gknd 9837 12 provided provide VBD cord-010119-t1x9gknd 9837 13 very very RB cord-010119-t1x9gknd 9837 14 good good JJ cord-010119-t1x9gknd 9837 15 performance performance NN cord-010119-t1x9gknd 9837 16 in in IN cord-010119-t1x9gknd 9837 17 sensitivity sensitivity NN cord-010119-t1x9gknd 9837 18 and and CC cord-010119-t1x9gknd 9837 19 specificity specificity NN cord-010119-t1x9gknd 9837 20 , , , cord-010119-t1x9gknd 9837 21 comparable comparable JJ cord-010119-t1x9gknd 9837 22 to to IN cord-010119-t1x9gknd 9837 23 the the DT cord-010119-t1x9gknd 9837 24 current current JJ cord-010119-t1x9gknd 9837 25 on on IN cord-010119-t1x9gknd 9837 26 - - HYPH cord-010119-t1x9gknd 9837 27 market market NN cord-010119-t1x9gknd 9837 28 anti anti JJ cord-010119-t1x9gknd 9837 29 - - JJ cord-010119-t1x9gknd 9837 30 T. t. JJ cord-010119-t1x9gknd 9837 31 cruzi cruzi NN cord-010119-t1x9gknd 9837 32 assay assay NN cord-010119-t1x9gknd 9837 33 , , , cord-010119-t1x9gknd 9837 34 and and CC cord-010119-t1x9gknd 9837 35 is be VBZ cord-010119-t1x9gknd 9837 36 equally equally RB cord-010119-t1x9gknd 9837 37 suitable suitable JJ cord-010119-t1x9gknd 9837 38 for for IN cord-010119-t1x9gknd 9837 39 use use NN cord-010119-t1x9gknd 9837 40 of of IN cord-010119-t1x9gknd 9837 41 universal universal JJ cord-010119-t1x9gknd 9837 42 screening screening NN cord-010119-t1x9gknd 9837 43 in in IN cord-010119-t1x9gknd 9837 44 endemic endemic JJ cord-010119-t1x9gknd 9837 45 and and CC cord-010119-t1x9gknd 9837 46 selective selective JJ cord-010119-t1x9gknd 9837 47 donor donor NN cord-010119-t1x9gknd 9837 48 screening screening NN cord-010119-t1x9gknd 9837 49 in in IN cord-010119-t1x9gknd 9837 50 non non JJ cord-010119-t1x9gknd 9837 51 - - JJ cord-010119-t1x9gknd 9837 52 endemic endemic JJ cord-010119-t1x9gknd 9837 53 countries country NNS cord-010119-t1x9gknd 9837 54 . . . cord-010119-t1x9gknd 9838 1 Performance performance NN cord-010119-t1x9gknd 9838 2 of of IN cord-010119-t1x9gknd 9838 3 a a DT cord-010119-t1x9gknd 9838 4 New New NNP cord-010119-t1x9gknd 9838 5 Automated Automated NNP cord-010119-t1x9gknd 9838 6 Alinity Alinity NNP cord-010119-t1x9gknd 9838 7 s s POS cord-010119-t1x9gknd 9838 8 Assay Assay NNP cord-010119-t1x9gknd 9838 9 for for IN cord-010119-t1x9gknd 9839 1 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 9839 2 B B NNP cord-010119-t1x9gknd 9839 3 Surface Surface NNP cord-010119-t1x9gknd 9839 4 Antigen Antigen NNP cord-010119-t1x9gknd 9839 5 and and CC cord-010119-t1x9gknd 9839 6 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 9839 7 B B NNP cord-010119-t1x9gknd 9839 8 Surface Surface NNP cord-010119-t1x9gknd 9839 9 Antigen Antigen NNP cord-010119-t1x9gknd 9839 10 Confirmatory Confirmatory NNP cord-010119-t1x9gknd 9839 11 Randal Randal NNP cord-010119-t1x9gknd 9839 12 Makela Makela NNP cord-010119-t1x9gknd 9839 13 * * NFP cord-010119-t1x9gknd 9839 14 1 1 CD cord-010119-t1x9gknd 9839 15 , , , cord-010119-t1x9gknd 9839 16 Anton Anton NNP cord-010119-t1x9gknd 9839 17 vanWeert vanWeert NNP cord-010119-t1x9gknd 9839 18 2 2 CD cord-010119-t1x9gknd 9839 19 , , , cord-010119-t1x9gknd 9839 20 Ed Ed NNP cord-010119-t1x9gknd 9839 21 Bakker Bakker NNP cord-010119-t1x9gknd 9839 22 2 2 CD cord-010119-t1x9gknd 9839 23 , , , cord-010119-t1x9gknd 9839 24 Jane Jane NNP cord-010119-t1x9gknd 9839 25 Bryant Bryant NNP cord-010119-t1x9gknd 9839 26 1 1 CD cord-010119-t1x9gknd 9839 27 , , , cord-010119-t1x9gknd 9839 28 Mark Mark NNP cord-010119-t1x9gknd 9839 29 Paradowski Paradowski NNP cord-010119-t1x9gknd 9839 30 1 1 CD cord-010119-t1x9gknd 9839 31 , , , cord-010119-t1x9gknd 9839 32 Lynn Lynn NNP cord-010119-t1x9gknd 9839 33 Martin Martin NNP cord-010119-t1x9gknd 9839 34 1 1 CD cord-010119-t1x9gknd 9839 35 , , , cord-010119-t1x9gknd 9839 36 Daniela Daniela NNP cord-010119-t1x9gknd 9839 37 Kaleve Kaleve NNP cord-010119-t1x9gknd 9839 38 3 3 CD cord-010119-t1x9gknd 9839 39 , , , cord-010119-t1x9gknd 9839 40 George George NNP cord-010119-t1x9gknd 9839 41 Chen Chen NNP cord-010119-t1x9gknd 9839 42 1 1 CD cord-010119-t1x9gknd 9839 43 , , , cord-010119-t1x9gknd 9839 44 Gregg Gregg NNP cord-010119-t1x9gknd 9839 45 Williams Williams NNP cord-010119-t1x9gknd 9839 46 1 1 CD cord-010119-t1x9gknd 9839 47 and and CC cord-010119-t1x9gknd 9839 48 George George NNP cord-010119-t1x9gknd 9839 49 Schlauder Schlauder NNP cord-010119-t1x9gknd 9839 50 4 4 CD cord-010119-t1x9gknd 9839 51 . . . cord-010119-t1x9gknd 9840 1 1 1 LS cord-010119-t1x9gknd 9841 1 Abbott Abbott NNP cord-010119-t1x9gknd 9841 2 Laboratories Laboratories NNP cord-010119-t1x9gknd 9841 3 , , , cord-010119-t1x9gknd 9841 4 2 2 CD cord-010119-t1x9gknd 9841 5 Sanguin Sanguin NNP cord-010119-t1x9gknd 9841 6 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 9841 7 , , , cord-010119-t1x9gknd 9841 8 3 3 CD cord-010119-t1x9gknd 9841 9 Abbott Abbott NNP cord-010119-t1x9gknd 9841 10 GmbH GmbH NNP cord-010119-t1x9gknd 9841 11 & & CC cord-010119-t1x9gknd 9841 12 Co. Co. NNP cord-010119-t1x9gknd 9841 13 KG KG NNP cord-010119-t1x9gknd 9841 14 , , , cord-010119-t1x9gknd 9841 15 4 4 CD cord-010119-t1x9gknd 9841 16 Abbott Abbott NNP cord-010119-t1x9gknd 9841 17 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9841 18 Background Background NNP cord-010119-t1x9gknd 9841 19 / / SYM cord-010119-t1x9gknd 9841 20 Case Case NNP cord-010119-t1x9gknd 9841 21 Studies Studies NNPS cord-010119-t1x9gknd 9841 22 : : : cord-010119-t1x9gknd 9842 1 Despite despite IN cord-010119-t1x9gknd 9842 2 the the DT cord-010119-t1x9gknd 9842 3 development development NN cord-010119-t1x9gknd 9842 4 of of IN cord-010119-t1x9gknd 9842 5 sensitive sensitive JJ cord-010119-t1x9gknd 9842 6 NAT NAT NNP cord-010119-t1x9gknd 9842 7 methods method NNS cord-010119-t1x9gknd 9842 8 , , , cord-010119-t1x9gknd 9842 9 blood blood NN cord-010119-t1x9gknd 9842 10 transfusion transfusion NN cord-010119-t1x9gknd 9842 11 in in IN cord-010119-t1x9gknd 9842 12 many many JJ cord-010119-t1x9gknd 9842 13 parts part NNS cord-010119-t1x9gknd 9842 14 of of IN cord-010119-t1x9gknd 9842 15 the the DT cord-010119-t1x9gknd 9842 16 world world NN cord-010119-t1x9gknd 9842 17 relies rely VBZ cord-010119-t1x9gknd 9842 18 on on IN cord-010119-t1x9gknd 9842 19 serologic serologic NN cord-010119-t1x9gknd 9842 20 screening screening NN cord-010119-t1x9gknd 9842 21 for for IN cord-010119-t1x9gknd 9842 22 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 9842 23 B B NNP cord-010119-t1x9gknd 9842 24 surface surface NN cord-010119-t1x9gknd 9842 25 antigen antigen NN cord-010119-t1x9gknd 9842 26 ( ( -LRB- cord-010119-t1x9gknd 9842 27 HBsAg hbsag ADD cord-010119-t1x9gknd 9842 28 ) ) -RRB- cord-010119-t1x9gknd 9842 29 to to TO cord-010119-t1x9gknd 9842 30 prevent prevent VB cord-010119-t1x9gknd 9842 31 transfusion transfusion NN cord-010119-t1x9gknd 9842 32 transmitted transmit VBN cord-010119-t1x9gknd 9842 33 HBV HBV NNP cord-010119-t1x9gknd 9842 34 infection infection NN cord-010119-t1x9gknd 9842 35 . . . cord-010119-t1x9gknd 9843 1 Sensitive sensitive JJ cord-010119-t1x9gknd 9843 2 HBsAg HBsAg NNP cord-010119-t1x9gknd 9843 3 assays assay NNS cord-010119-t1x9gknd 9843 4 must must MD cord-010119-t1x9gknd 9843 5 be be VB cord-010119-t1x9gknd 9843 6 capable capable JJ cord-010119-t1x9gknd 9843 7 of of IN cord-010119-t1x9gknd 9843 8 coping cope VBG cord-010119-t1x9gknd 9843 9 with with IN cord-010119-t1x9gknd 9843 10 a a DT cord-010119-t1x9gknd 9843 11 wide wide JJ cord-010119-t1x9gknd 9843 12 range range NN cord-010119-t1x9gknd 9843 13 of of IN cord-010119-t1x9gknd 9843 14 mutants mutant NNS cord-010119-t1x9gknd 9843 15 while while IN cord-010119-t1x9gknd 9843 16 exhibiting exhibit VBG cord-010119-t1x9gknd 9843 17 an an DT cord-010119-t1x9gknd 9843 18 uncompromised uncompromised JJ cord-010119-t1x9gknd 9843 19 specificity specificity NN cord-010119-t1x9gknd 9843 20 . . . cord-010119-t1x9gknd 9844 1 In in IN cord-010119-t1x9gknd 9844 2 addition addition NN cord-010119-t1x9gknd 9844 3 , , , cord-010119-t1x9gknd 9844 4 continued continue VBN cord-010119-t1x9gknd 9844 5 pressures pressure NNS cord-010119-t1x9gknd 9844 6 on on IN cord-010119-t1x9gknd 9844 7 laboratory laboratory NN cord-010119-t1x9gknd 9844 8 operations operation NNS cord-010119-t1x9gknd 9844 9 demand demand VBP cord-010119-t1x9gknd 9844 10 that that IN cord-010119-t1x9gknd 9844 11 assays assay NNS cord-010119-t1x9gknd 9844 12 perform perform VBP cord-010119-t1x9gknd 9844 13 on on IN cord-010119-t1x9gknd 9844 14 platforms platform NNS cord-010119-t1x9gknd 9844 15 capable capable JJ cord-010119-t1x9gknd 9844 16 of of IN cord-010119-t1x9gknd 9844 17 increased increase VBN cord-010119-t1x9gknd 9844 18 walk walk NN cord-010119-t1x9gknd 9844 19 away away RB cord-010119-t1x9gknd 9844 20 time time NN cord-010119-t1x9gknd 9844 21 and and CC cord-010119-t1x9gknd 9844 22 enhanced enhanced JJ cord-010119-t1x9gknd 9844 23 automation automation NN cord-010119-t1x9gknd 9844 24 in in IN cord-010119-t1x9gknd 9844 25 areas area NNS cord-010119-t1x9gknd 9844 26 of of IN cord-010119-t1x9gknd 9844 27 reagent reagent NN cord-010119-t1x9gknd 9844 28 management management NN cord-010119-t1x9gknd 9844 29 , , , cord-010119-t1x9gknd 9844 30 retest retest VB cord-010119-t1x9gknd 9844 31 options option NNS cord-010119-t1x9gknd 9844 32 , , , cord-010119-t1x9gknd 9844 33 and and CC cord-010119-t1x9gknd 9844 34 commodity commodity NN cord-010119-t1x9gknd 9844 35 / / SYM cord-010119-t1x9gknd 9844 36 waste waste NN cord-010119-t1x9gknd 9844 37 management management NN cord-010119-t1x9gknd 9844 38 . . . cord-010119-t1x9gknd 9845 1 Study Study NNP cord-010119-t1x9gknd 9845 2 Design Design NNP cord-010119-t1x9gknd 9845 3 / / SYM cord-010119-t1x9gknd 9845 4 Method method NN cord-010119-t1x9gknd 9845 5 : : : cord-010119-t1x9gknd 9846 1 The the DT cord-010119-t1x9gknd 9846 2 performance performance NN cord-010119-t1x9gknd 9846 3 of of IN cord-010119-t1x9gknd 9846 4 a a DT cord-010119-t1x9gknd 9846 5 new new JJ cord-010119-t1x9gknd 9846 6 automated automate VBN cord-010119-t1x9gknd 9846 7 chemiluminescence chemiluminescence NN cord-010119-t1x9gknd 9846 8 immunoassay immunoassay NN cord-010119-t1x9gknd 9846 9 for for IN cord-010119-t1x9gknd 9846 10 the the DT cord-010119-t1x9gknd 9846 11 detection detection NN cord-010119-t1x9gknd 9846 12 and and CC cord-010119-t1x9gknd 9846 13 confirmation confirmation NN cord-010119-t1x9gknd 9846 14 of of IN cord-010119-t1x9gknd 9846 15 HBsAg HBsAg NNP cord-010119-t1x9gknd 9846 16 was be VBD cord-010119-t1x9gknd 9846 17 evaluated evaluate VBN cord-010119-t1x9gknd 9846 18 on on IN cord-010119-t1x9gknd 9846 19 a a DT cord-010119-t1x9gknd 9846 20 next next JJ cord-010119-t1x9gknd 9846 21 generation generation NN cord-010119-t1x9gknd 9846 22 automated automate VBN cord-010119-t1x9gknd 9846 23 platform platform NN cord-010119-t1x9gknd 9846 24 , , , cord-010119-t1x9gknd 9846 25 Abbott Abbott NNP cord-010119-t1x9gknd 9846 26 Alinity Alinity NNP cord-010119-t1x9gknd 9846 27 s. s. NNP cord-010119-t1x9gknd 9846 28 Precision Precision NNP cord-010119-t1x9gknd 9846 29 was be VBD cord-010119-t1x9gknd 9846 30 assessed assess VBN cord-010119-t1x9gknd 9846 31 over over IN cord-010119-t1x9gknd 9846 32 20 20 CD cord-010119-t1x9gknd 9846 33 days day NNS cord-010119-t1x9gknd 9846 34 . . . cord-010119-t1x9gknd 9847 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9847 2 was be VBD cord-010119-t1x9gknd 9847 3 evaluated evaluate VBN cord-010119-t1x9gknd 9847 4 using use VBG cord-010119-t1x9gknd 9847 5 511 511 CD cord-010119-t1x9gknd 9847 6 known know VBN cord-010119-t1x9gknd 9847 7 positive positive JJ cord-010119-t1x9gknd 9847 8 samples sample NNS cord-010119-t1x9gknd 9847 9 , , , cord-010119-t1x9gknd 9847 10 30 30 CD cord-010119-t1x9gknd 9847 11 commercially commercially RB cord-010119-t1x9gknd 9847 12 available available JJ cord-010119-t1x9gknd 9847 13 seroconversion seroconversion NN cord-010119-t1x9gknd 9847 14 panels panel NNS cord-010119-t1x9gknd 9847 15 , , , cord-010119-t1x9gknd 9847 16 the the DT cord-010119-t1x9gknd 9847 17 WHO WHO NNP cord-010119-t1x9gknd 9847 18 standard standard NN cord-010119-t1x9gknd 9847 19 , , , cord-010119-t1x9gknd 9847 20 23 23 CD cord-010119-t1x9gknd 9847 21 HBsAg hbsag ADD cord-010119-t1x9gknd 9847 22 mutants mutant NNS cord-010119-t1x9gknd 9847 23 , , , cord-010119-t1x9gknd 9847 24 and and CC cord-010119-t1x9gknd 9847 25 94 94 CD cord-010119-t1x9gknd 9847 26 HBsAg hbsag CD cord-010119-t1x9gknd 9847 27 genotyped genotype VBD cord-010119-t1x9gknd 9847 28 specimens specimen NNS cord-010119-t1x9gknd 9847 29 ( ( -LRB- cord-010119-t1x9gknd 9847 30 A a NN cord-010119-t1x9gknd 9847 31 through through IN cord-010119-t1x9gknd 9847 32 H h NN cord-010119-t1x9gknd 9847 33 ) ) -RRB- cord-010119-t1x9gknd 9847 34 . . . cord-010119-t1x9gknd 9848 1 Specificity specificity NN cord-010119-t1x9gknd 9848 2 was be VBD cord-010119-t1x9gknd 9848 3 evaluated evaluate VBN cord-010119-t1x9gknd 9848 4 on on IN cord-010119-t1x9gknd 9848 5 random random JJ cord-010119-t1x9gknd 9848 6 blood blood NN cord-010119-t1x9gknd 9848 7 and and CC cord-010119-t1x9gknd 9848 8 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 9848 9 donors donor NNS cord-010119-t1x9gknd 9848 10 . . . cord-010119-t1x9gknd 9849 1 Results/ Results/ . cord-010119-t1x9gknd 9850 1 Finding finding NN cord-010119-t1x9gknd 9850 2 : : : cord-010119-t1x9gknd 9851 1 Precision precision NN cord-010119-t1x9gknd 9851 2 was be VBD cord-010119-t1x9gknd 9851 3 less less JJR cord-010119-t1x9gknd 9851 4 than than IN cord-010119-t1x9gknd 9851 5 8 8 CD cord-010119-t1x9gknd 9851 6 % % NN cord-010119-t1x9gknd 9851 7 CV cv NN cord-010119-t1x9gknd 9851 8 for for IN cord-010119-t1x9gknd 9851 9 positive positive JJ cord-010119-t1x9gknd 9851 10 samples sample NNS cord-010119-t1x9gknd 9851 11 over over IN cord-010119-t1x9gknd 9851 12 20 20 CD cord-010119-t1x9gknd 9851 13 days day NNS cord-010119-t1x9gknd 9851 14 . . . cord-010119-t1x9gknd 9852 1 The the DT cord-010119-t1x9gknd 9852 2 blood blood NN cord-010119-t1x9gknd 9852 3 donor donor NN cord-010119-t1x9gknd 9852 4 specificity specificity NN cord-010119-t1x9gknd 9852 5 was be VBD cord-010119-t1x9gknd 9852 6 99.98 99.98 CD cord-010119-t1x9gknd 9852 7 % % NN cord-010119-t1x9gknd 9852 8 ( ( -LRB- cord-010119-t1x9gknd 9852 9 7998/8000 7998/8000 CD cord-010119-t1x9gknd 9852 10 ) ) -RRB- cord-010119-t1x9gknd 9852 11 . . . cord-010119-t1x9gknd 9853 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9853 2 was be VBD cord-010119-t1x9gknd 9853 3 100 100 CD cord-010119-t1x9gknd 9853 4 % % NN cord-010119-t1x9gknd 9853 5 for for IN cord-010119-t1x9gknd 9853 6 511 511 CD cord-010119-t1x9gknd 9853 7 presumed presume VBN cord-010119-t1x9gknd 9853 8 positive positive JJ cord-010119-t1x9gknd 9853 9 samples sample NNS cord-010119-t1x9gknd 9853 10 . . . cord-010119-t1x9gknd 9854 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9854 2 was be VBD cord-010119-t1x9gknd 9854 3 100 100 CD cord-010119-t1x9gknd 9854 4 % % NN cord-010119-t1x9gknd 9854 5 for for IN cord-010119-t1x9gknd 9854 6 all all DT cord-010119-t1x9gknd 9854 7 genotypes genotype NNS cord-010119-t1x9gknd 9854 8 . . . cord-010119-t1x9gknd 9855 1 100 100 CD cord-010119-t1x9gknd 9855 2 % % NN cord-010119-t1x9gknd 9855 3 of of IN cord-010119-t1x9gknd 9855 4 the the DT cord-010119-t1x9gknd 9855 5 mutants mutant NNS cord-010119-t1x9gknd 9855 6 were be VBD cord-010119-t1x9gknd 9855 7 detected detect VBN cord-010119-t1x9gknd 9855 8 vs vs IN cord-010119-t1x9gknd 9855 9 83 83 CD cord-010119-t1x9gknd 9855 10 % % NN cord-010119-t1x9gknd 9855 11 for for IN cord-010119-t1x9gknd 9855 12 the the DT cord-010119-t1x9gknd 9855 13 comparator comparator NN cord-010119-t1x9gknd 9855 14 assay assay NN cord-010119-t1x9gknd 9855 15 . . . cord-010119-t1x9gknd 9856 1 Seroconversion seroconversion NN cord-010119-t1x9gknd 9856 2 detection detection NN cord-010119-t1x9gknd 9856 3 was be VBD cord-010119-t1x9gknd 9856 4 equivalent equivalent JJ cord-010119-t1x9gknd 9856 5 to to IN cord-010119-t1x9gknd 9856 6 the the DT cord-010119-t1x9gknd 9856 7 comparator comparator NN cord-010119-t1x9gknd 9856 8 assay assay NN cord-010119-t1x9gknd 9856 9 with with IN cord-010119-t1x9gknd 9856 10 157 157 CD cord-010119-t1x9gknd 9856 11 reactive reactive JJ cord-010119-t1x9gknd 9856 12 samples sample NNS cord-010119-t1x9gknd 9856 13 detected detect VBN cord-010119-t1x9gknd 9856 14 with with IN cord-010119-t1x9gknd 9856 15 the the DT cord-010119-t1x9gknd 9856 16 Alinity Alinity NNP cord-010119-t1x9gknd 9856 17 s s POS cord-010119-t1x9gknd 9856 18 assay assay NN cord-010119-t1x9gknd 9856 19 and and CC cord-010119-t1x9gknd 9856 20 154 154 CD cord-010119-t1x9gknd 9856 21 reactive reactive JJ cord-010119-t1x9gknd 9856 22 samples sample NNS cord-010119-t1x9gknd 9856 23 detected detect VBN cord-010119-t1x9gknd 9856 24 by by IN cord-010119-t1x9gknd 9856 25 the the DT cord-010119-t1x9gknd 9856 26 comparator comparator NN cord-010119-t1x9gknd 9856 27 assay assay NN cord-010119-t1x9gknd 9856 28 . . . cord-010119-t1x9gknd 9857 1 Analytical analytical JJ cord-010119-t1x9gknd 9857 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9857 3 ranged range VBD cord-010119-t1x9gknd 9857 4 from from IN cord-010119-t1x9gknd 9857 5 0.015 0.015 CD cord-010119-t1x9gknd 9857 6 to to IN cord-010119-t1x9gknd 9857 7 0.016 0.016 CD cord-010119-t1x9gknd 9857 8 IU IU NNP cord-010119-t1x9gknd 9857 9 / / , cord-010119-t1x9gknd 9857 10 ml ml NN cord-010119-t1x9gknd 9857 11 . . . cord-010119-t1x9gknd 9858 1 The the DT cord-010119-t1x9gknd 9858 2 Alinity Alinity NNP cord-010119-t1x9gknd 9858 3 s s POS cord-010119-t1x9gknd 9858 4 HBsAg hbsag CD cord-010119-t1x9gknd 9858 5 Confirmatory Confirmatory NNP cord-010119-t1x9gknd 9858 6 Assay Assay NNP cord-010119-t1x9gknd 9858 7 confirmed confirm VBD cord-010119-t1x9gknd 9858 8 all all DT cord-010119-t1x9gknd 9858 9 known know VBN cord-010119-t1x9gknd 9858 10 positive positive JJ cord-010119-t1x9gknd 9858 11 HBsAg hbsag CD cord-010119-t1x9gknd 9858 12 specimens specimen NNS cord-010119-t1x9gknd 9858 13 , , , cord-010119-t1x9gknd 9858 14 including include VBG cord-010119-t1x9gknd 9858 15 3 3 CD cord-010119-t1x9gknd 9858 16 HBsAg HBsAg NNP cord-010119-t1x9gknd 9858 17 mutant mutant JJ cord-010119-t1x9gknd 9858 18 samples sample NNS cord-010119-t1x9gknd 9858 19 that that WDT cord-010119-t1x9gknd 9858 20 were be VBD cord-010119-t1x9gknd 9858 21 not not RB cord-010119-t1x9gknd 9858 22 confirmed confirm VBN cord-010119-t1x9gknd 9858 23 by by IN cord-010119-t1x9gknd 9858 24 the the DT cord-010119-t1x9gknd 9858 25 comparator comparator NN cord-010119-t1x9gknd 9858 26 HBsAg hbsag ADD cord-010119-t1x9gknd 9858 27 Confirmatory Confirmatory NNP cord-010119-t1x9gknd 9858 28 Assay Assay NNP cord-010119-t1x9gknd 9858 29 . . . cord-010119-t1x9gknd 9859 1 Conclusion conclusion NN cord-010119-t1x9gknd 9859 2 : : : cord-010119-t1x9gknd 9860 1 The the DT cord-010119-t1x9gknd 9860 2 new new JJ cord-010119-t1x9gknd 9860 3 automated automate VBN cord-010119-t1x9gknd 9860 4 Alinity Alinity NNP cord-010119-t1x9gknd 9860 5 s s POS cord-010119-t1x9gknd 9860 6 HBsAg HBsAg NNP cord-010119-t1x9gknd 9860 7 assay assay NN cord-010119-t1x9gknd 9860 8 provided provide VBD cord-010119-t1x9gknd 9860 9 precision precision NN cord-010119-t1x9gknd 9860 10 , , , cord-010119-t1x9gknd 9860 11 specificity specificity NN cord-010119-t1x9gknd 9860 12 , , , cord-010119-t1x9gknd 9860 13 and and CC cord-010119-t1x9gknd 9860 14 seroconversion seroconversion NN cord-010119-t1x9gknd 9860 15 sensitivity sensitivity NN cord-010119-t1x9gknd 9860 16 comparable comparable JJ cord-010119-t1x9gknd 9860 17 to to IN cord-010119-t1x9gknd 9860 18 the the DT cord-010119-t1x9gknd 9860 19 current current JJ cord-010119-t1x9gknd 9860 20 onmarket onmarket NN cord-010119-t1x9gknd 9860 21 comparator comparator NN cord-010119-t1x9gknd 9860 22 assay assay NN cord-010119-t1x9gknd 9860 23 . . . cord-010119-t1x9gknd 9861 1 However however RB cord-010119-t1x9gknd 9861 2 , , , cord-010119-t1x9gknd 9861 3 the the DT cord-010119-t1x9gknd 9861 4 Alinity Alinity NNP cord-010119-t1x9gknd 9861 5 s s POS cord-010119-t1x9gknd 9861 6 HBsAg HBsAg NNP cord-010119-t1x9gknd 9861 7 assay assay NN cord-010119-t1x9gknd 9861 8 demonstrated demonstrate VBD cord-010119-t1x9gknd 9861 9 a a DT cord-010119-t1x9gknd 9861 10 gain gain NN cord-010119-t1x9gknd 9861 11 in in IN cord-010119-t1x9gknd 9861 12 sensitivity sensitivity NN cord-010119-t1x9gknd 9861 13 over over IN cord-010119-t1x9gknd 9861 14 the the DT cord-010119-t1x9gknd 9861 15 comparator comparator NN cord-010119-t1x9gknd 9861 16 assay assay NN cord-010119-t1x9gknd 9861 17 through through IN cord-010119-t1x9gknd 9861 18 the the DT cord-010119-t1x9gknd 9861 19 detection detection NN cord-010119-t1x9gknd 9861 20 and and CC cord-010119-t1x9gknd 9861 21 confirmation confirmation NN cord-010119-t1x9gknd 9861 22 of of IN cord-010119-t1x9gknd 9861 23 a a DT cord-010119-t1x9gknd 9861 24 wider wide JJR cord-010119-t1x9gknd 9861 25 range range NN cord-010119-t1x9gknd 9861 26 of of IN cord-010119-t1x9gknd 9861 27 mutants mutant NNS cord-010119-t1x9gknd 9861 28 . . . cord-010119-t1x9gknd 9862 1 Performance performance NN cord-010119-t1x9gknd 9862 2 of of IN cord-010119-t1x9gknd 9862 3 a a DT cord-010119-t1x9gknd 9862 4 New New NNP cord-010119-t1x9gknd 9862 5 Automated Automated NNP cord-010119-t1x9gknd 9862 6 Alinity Alinity NNP cord-010119-t1x9gknd 9862 7 s s NNP cord-010119-t1x9gknd 9862 8 Immunoassay Immunoassay NNP cord-010119-t1x9gknd 9862 9 Assay Assay NNP cord-010119-t1x9gknd 9862 10 for for IN cord-010119-t1x9gknd 9862 11 HIV HIV NNP cord-010119-t1x9gknd 9862 12 Darwin Darwin NNP cord-010119-t1x9gknd 9862 13 Smith Smith NNP cord-010119-t1x9gknd 9863 1 * * NFP cord-010119-t1x9gknd 9863 2 1 1 CD cord-010119-t1x9gknd 9863 3 , , , cord-010119-t1x9gknd 9863 4 Ed Ed NNP cord-010119-t1x9gknd 9863 5 Bakker Bakker NNP cord-010119-t1x9gknd 9863 6 2 2 CD cord-010119-t1x9gknd 9863 7 , , , cord-010119-t1x9gknd 9863 8 Anton Anton NNP cord-010119-t1x9gknd 9863 9 van van NNP cord-010119-t1x9gknd 9863 10 Weert Weert NNP cord-010119-t1x9gknd 9863 11 2 2 CD cord-010119-t1x9gknd 9863 12 , , , cord-010119-t1x9gknd 9863 13 Jane Jane NNP cord-010119-t1x9gknd 9863 14 Bryant Bryant NNP cord-010119-t1x9gknd 9863 15 1 1 CD cord-010119-t1x9gknd 9863 16 , , , cord-010119-t1x9gknd 9863 17 Mark Mark NNP cord-010119-t1x9gknd 9863 18 Paradowski Paradowski NNP cord-010119-t1x9gknd 9863 19 1 1 CD cord-010119-t1x9gknd 9863 20 , , , cord-010119-t1x9gknd 9863 21 Kevin Kevin NNP cord-010119-t1x9gknd 9863 22 Callear Callear NNP cord-010119-t1x9gknd 9863 23 1 1 CD cord-010119-t1x9gknd 9863 24 , , , cord-010119-t1x9gknd 9863 25 Susan Susan NNP cord-010119-t1x9gknd 9863 26 Sullivan Sullivan NNP cord-010119-t1x9gknd 9863 27 1 1 CD cord-010119-t1x9gknd 9863 28 , , , cord-010119-t1x9gknd 9863 29 George George NNP cord-010119-t1x9gknd 9863 30 Chen Chen NNP cord-010119-t1x9gknd 9863 31 1 1 CD cord-010119-t1x9gknd 9863 32 , , , cord-010119-t1x9gknd 9863 33 George George NNP cord-010119-t1x9gknd 9863 34 Schlauder Schlauder NNP cord-010119-t1x9gknd 9863 35 1 1 CD cord-010119-t1x9gknd 9863 36 and and CC cord-010119-t1x9gknd 9863 37 Gregg Gregg NNP cord-010119-t1x9gknd 9863 38 Williams Williams NNP cord-010119-t1x9gknd 9863 39 1 1 CD cord-010119-t1x9gknd 9863 40 . . . cord-010119-t1x9gknd 9864 1 1 1 LS cord-010119-t1x9gknd 9864 2 Abbott Abbott NNP cord-010119-t1x9gknd 9864 3 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9864 4 , , , cord-010119-t1x9gknd 9864 5 2 2 CD cord-010119-t1x9gknd 9864 6 Sanquin Sanquin NNP cord-010119-t1x9gknd 9864 7 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9864 8 Background Background NNP cord-010119-t1x9gknd 9864 9 / / SYM cord-010119-t1x9gknd 9864 10 Case Case NNP cord-010119-t1x9gknd 9864 11 Studies Studies NNPS cord-010119-t1x9gknd 9864 12 : : : cord-010119-t1x9gknd 9864 13 Blood blood NN cord-010119-t1x9gknd 9864 14 donations donation NNS cord-010119-t1x9gknd 9864 15 are be VBP cord-010119-t1x9gknd 9864 16 commonly commonly RB cord-010119-t1x9gknd 9864 17 screened screen VBN cord-010119-t1x9gknd 9864 18 to to TO cord-010119-t1x9gknd 9864 19 detect detect VB cord-010119-t1x9gknd 9864 20 the the DT cord-010119-t1x9gknd 9864 21 presence presence NN cord-010119-t1x9gknd 9864 22 of of IN cord-010119-t1x9gknd 9864 23 antibodies antibody NNS cord-010119-t1x9gknd 9864 24 ( ( -LRB- cord-010119-t1x9gknd 9864 25 or or CC cord-010119-t1x9gknd 9864 26 antibody antibody NN cord-010119-t1x9gknd 9864 27 and and CC cord-010119-t1x9gknd 9864 28 antigen antigen NN cord-010119-t1x9gknd 9864 29 ) ) -RRB- cord-010119-t1x9gknd 9864 30 to to IN cord-010119-t1x9gknd 9864 31 human human JJ cord-010119-t1x9gknd 9864 32 immunodeficiency immunodeficiency NN cord-010119-t1x9gknd 9864 33 virus virus NN cord-010119-t1x9gknd 9864 34 Types Types NNP cord-010119-t1x9gknd 9864 35 1 1 CD cord-010119-t1x9gknd 9864 36 and and CC cord-010119-t1x9gknd 9864 37 2 2 CD cord-010119-t1x9gknd 9865 1 ( ( -LRB- cord-010119-t1x9gknd 9865 2 anti anti JJ cord-010119-t1x9gknd 9865 3 - - JJ cord-010119-t1x9gknd 9865 4 HIV-1/2 hiv-1/2 JJ cord-010119-t1x9gknd 9865 5 ) ) -RRB- cord-010119-t1x9gknd 9865 6 . . . cord-010119-t1x9gknd 9866 1 Blood blood NN cord-010119-t1x9gknd 9866 2 centers center NNS cord-010119-t1x9gknd 9866 3 require require VBP cord-010119-t1x9gknd 9866 4 very very RB cord-010119-t1x9gknd 9866 5 high high JJ cord-010119-t1x9gknd 9866 6 throughput throughput NN cord-010119-t1x9gknd 9866 7 anti anti NN cord-010119-t1x9gknd 9866 8 - - JJ cord-010119-t1x9gknd 9866 9 HIV-1/2 hiv-1/2 RB cord-010119-t1x9gknd 9866 10 assays assay NNS cord-010119-t1x9gknd 9866 11 with with IN cord-010119-t1x9gknd 9866 12 high high JJ cord-010119-t1x9gknd 9866 13 specificity specificity NN cord-010119-t1x9gknd 9866 14 and and CC cord-010119-t1x9gknd 9866 15 sensitivity sensitivity NN cord-010119-t1x9gknd 9866 16 to to TO cord-010119-t1x9gknd 9866 17 prevent prevent VB cord-010119-t1x9gknd 9866 18 unnecessary unnecessary JJ cord-010119-t1x9gknd 9866 19 donor donor NN cord-010119-t1x9gknd 9866 20 deferrals deferral NNS cord-010119-t1x9gknd 9866 21 while while IN cord-010119-t1x9gknd 9866 22 maintaining maintain VBG cord-010119-t1x9gknd 9866 23 a a DT cord-010119-t1x9gknd 9866 24 safe safe JJ cord-010119-t1x9gknd 9866 25 blood blood NN cord-010119-t1x9gknd 9866 26 supply supply NN cord-010119-t1x9gknd 9866 27 . . . cord-010119-t1x9gknd 9867 1 In in IN cord-010119-t1x9gknd 9867 2 addition addition NN cord-010119-t1x9gknd 9867 3 , , , cord-010119-t1x9gknd 9867 4 continued continue VBN cord-010119-t1x9gknd 9867 5 pressures pressure NNS cord-010119-t1x9gknd 9867 6 on on IN cord-010119-t1x9gknd 9867 7 laboratory laboratory NN cord-010119-t1x9gknd 9867 8 operations operation NNS cord-010119-t1x9gknd 9867 9 demand demand VBP cord-010119-t1x9gknd 9867 10 that that IN cord-010119-t1x9gknd 9867 11 assays assay NNS cord-010119-t1x9gknd 9867 12 perform perform VBP cord-010119-t1x9gknd 9867 13 on on IN cord-010119-t1x9gknd 9867 14 platforms platform NNS cord-010119-t1x9gknd 9867 15 capable capable JJ cord-010119-t1x9gknd 9867 16 of of IN cord-010119-t1x9gknd 9867 17 increased increase VBN cord-010119-t1x9gknd 9867 18 walk walk NN cord-010119-t1x9gknd 9867 19 away away RB cord-010119-t1x9gknd 9867 20 time time NN cord-010119-t1x9gknd 9867 21 and and CC cord-010119-t1x9gknd 9867 22 enhanced enhanced JJ cord-010119-t1x9gknd 9867 23 automation automation NN cord-010119-t1x9gknd 9867 24 in in IN cord-010119-t1x9gknd 9867 25 areas area NNS cord-010119-t1x9gknd 9867 26 of of IN cord-010119-t1x9gknd 9867 27 reagent reagent NN cord-010119-t1x9gknd 9867 28 management management NN cord-010119-t1x9gknd 9867 29 , , , cord-010119-t1x9gknd 9867 30 retest retest VB cord-010119-t1x9gknd 9867 31 options option NNS cord-010119-t1x9gknd 9867 32 , , , cord-010119-t1x9gknd 9867 33 and and CC cord-010119-t1x9gknd 9867 34 commodity commodity NN cord-010119-t1x9gknd 9867 35 / / SYM cord-010119-t1x9gknd 9867 36 waste waste NN cord-010119-t1x9gknd 9867 37 management management NN cord-010119-t1x9gknd 9867 38 . . . cord-010119-t1x9gknd 9868 1 In in IN cord-010119-t1x9gknd 9868 2 the the DT cord-010119-t1x9gknd 9868 3 response response NN cord-010119-t1x9gknd 9868 4 for for IN cord-010119-t1x9gknd 9868 5 the the DT cord-010119-t1x9gknd 9868 6 need need NN cord-010119-t1x9gknd 9868 7 for for IN cord-010119-t1x9gknd 9868 8 such such JJ cord-010119-t1x9gknd 9868 9 screening screening NN cord-010119-t1x9gknd 9868 10 assays assay NNS cord-010119-t1x9gknd 9868 11 , , , cord-010119-t1x9gknd 9868 12 we -PRON- PRP cord-010119-t1x9gknd 9868 13 have have VBP cord-010119-t1x9gknd 9868 14 evaluated evaluate VBN cord-010119-t1x9gknd 9868 15 an an DT cord-010119-t1x9gknd 9868 16 improved improved JJ cord-010119-t1x9gknd 9868 17 automated automated JJ cord-010119-t1x9gknd 9868 18 assay assay NN cord-010119-t1x9gknd 9868 19 for for IN cord-010119-t1x9gknd 9868 20 the the DT cord-010119-t1x9gknd 9868 21 detection detection NN cord-010119-t1x9gknd 9868 22 of of IN cord-010119-t1x9gknd 9868 23 anti anti JJ cord-010119-t1x9gknd 9868 24 - - JJ cord-010119-t1x9gknd 9868 25 HIV-1/2 hiv-1/2 JJ cord-010119-t1x9gknd 9868 26 antibodies antibody NNS cord-010119-t1x9gknd 9868 27 and and CC cord-010119-t1x9gknd 9868 28 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9868 29 p24 p24 NN cord-010119-t1x9gknd 9868 30 antigen antigen NN cord-010119-t1x9gknd 9868 31 . . . cord-010119-t1x9gknd 9869 1 Study Study NNP cord-010119-t1x9gknd 9869 2 Design Design NNP cord-010119-t1x9gknd 9869 3 / / SYM cord-010119-t1x9gknd 9869 4 Method method NN cord-010119-t1x9gknd 9869 5 : : : cord-010119-t1x9gknd 9870 1 The the DT cord-010119-t1x9gknd 9870 2 performance performance NN cord-010119-t1x9gknd 9870 3 of of IN cord-010119-t1x9gknd 9870 4 the the DT cord-010119-t1x9gknd 9870 5 new new JJ cord-010119-t1x9gknd 9870 6 chemiluminescence chemiluminescence NN cord-010119-t1x9gknd 9870 7 combination combination NN cord-010119-t1x9gknd 9870 8 immunoassay immunoassay NN cord-010119-t1x9gknd 9870 9 for for IN cord-010119-t1x9gknd 9870 10 the the DT cord-010119-t1x9gknd 9870 11 detection detection NN cord-010119-t1x9gknd 9870 12 of of IN cord-010119-t1x9gknd 9870 13 anti anti JJ cord-010119-t1x9gknd 9870 14 - - JJ cord-010119-t1x9gknd 9870 15 HIV-1/2 hiv-1/2 JJ cord-010119-t1x9gknd 9870 16 antibodies antibody NNS cord-010119-t1x9gknd 9870 17 and and CC cord-010119-t1x9gknd 9870 18 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9870 19 p24 p24 NN cord-010119-t1x9gknd 9870 20 antigen antigen NN cord-010119-t1x9gknd 9870 21 was be VBD cord-010119-t1x9gknd 9870 22 evaluated evaluate VBN cord-010119-t1x9gknd 9870 23 on on IN cord-010119-t1x9gknd 9870 24 the the DT cord-010119-t1x9gknd 9870 25 Abbott Abbott NNP cord-010119-t1x9gknd 9870 26 Alinity Alinity NNP cord-010119-t1x9gknd 9870 27 s s POS cord-010119-t1x9gknd 9870 28 System System NNP cord-010119-t1x9gknd 9870 29 . . . cord-010119-t1x9gknd 9871 1 Precision precision NN cord-010119-t1x9gknd 9871 2 was be VBD cord-010119-t1x9gknd 9871 3 assessed assess VBN cord-010119-t1x9gknd 9871 4 over over IN cord-010119-t1x9gknd 9871 5 20 20 CD cord-010119-t1x9gknd 9871 6 days day NNS cord-010119-t1x9gknd 9871 7 evaluating evaluate VBG cord-010119-t1x9gknd 9871 8 positive positive JJ cord-010119-t1x9gknd 9871 9 samples sample NNS cord-010119-t1x9gknd 9871 10 . . . cord-010119-t1x9gknd 9872 1 Specificity specificity NN cord-010119-t1x9gknd 9872 2 was be VBD cord-010119-t1x9gknd 9872 3 evaluated evaluate VBN cord-010119-t1x9gknd 9872 4 on on IN cord-010119-t1x9gknd 9872 5 samples sample NNS cord-010119-t1x9gknd 9872 6 obtained obtain VBN cord-010119-t1x9gknd 9872 7 from from IN cord-010119-t1x9gknd 9872 8 random random JJ cord-010119-t1x9gknd 9872 9 blood blood NN cord-010119-t1x9gknd 9872 10 donors donor NNS cord-010119-t1x9gknd 9872 11 and and CC cord-010119-t1x9gknd 9872 12 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 9872 13 donors donor NNS cord-010119-t1x9gknd 9872 14 . . . cord-010119-t1x9gknd 9873 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9873 2 was be VBD cord-010119-t1x9gknd 9873 3 evaluated evaluate VBN cord-010119-t1x9gknd 9873 4 using use VBG cord-010119-t1x9gknd 9873 5 presumed presume VBN cord-010119-t1x9gknd 9873 6 positive positive JJ cord-010119-t1x9gknd 9873 7 samples sample NNS cord-010119-t1x9gknd 9873 8 for for IN cord-010119-t1x9gknd 9873 9 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9873 10 , , , cord-010119-t1x9gknd 9873 11 HIV-2 HIV-2 NNP cord-010119-t1x9gknd 9873 12 and and CC cord-010119-t1x9gknd 9873 13 HIV HIV NNP cord-010119-t1x9gknd 9873 14 Group Group NNP cord-010119-t1x9gknd 9873 15 O O NNP cord-010119-t1x9gknd 9873 16 antibodies antibody NNS cord-010119-t1x9gknd 9873 17 and and CC cord-010119-t1x9gknd 9873 18 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9873 19 p24 p24 NN cord-010119-t1x9gknd 9873 20 antigen antigen NN cord-010119-t1x9gknd 9873 21 . . . cord-010119-t1x9gknd 9874 1 Seroconversion seroconversion NN cord-010119-t1x9gknd 9874 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9874 3 was be VBD cord-010119-t1x9gknd 9874 4 evaluated evaluate VBN cord-010119-t1x9gknd 9874 5 with with IN cord-010119-t1x9gknd 9874 6 41 41 CD cord-010119-t1x9gknd 9874 7 commercial commercial JJ cord-010119-t1x9gknd 9874 8 seroconversion seroconversion NN cord-010119-t1x9gknd 9874 9 panels panel NNS cord-010119-t1x9gknd 9874 10 . . . cord-010119-t1x9gknd 9875 1 Results/ Results/ . cord-010119-t1x9gknd 9876 1 Finding finding NN cord-010119-t1x9gknd 9876 2 : : : cord-010119-t1x9gknd 9877 1 Precision precision NN cord-010119-t1x9gknd 9877 2 was be VBD cord-010119-t1x9gknd 9877 3 less less JJR cord-010119-t1x9gknd 9877 4 than than IN cord-010119-t1x9gknd 9877 5 8 8 CD cord-010119-t1x9gknd 9877 6 % % NN cord-010119-t1x9gknd 9877 7 CV cv NN cord-010119-t1x9gknd 9877 8 for for IN cord-010119-t1x9gknd 9877 9 positive positive JJ cord-010119-t1x9gknd 9877 10 samples sample NNS cord-010119-t1x9gknd 9877 11 over over IN cord-010119-t1x9gknd 9877 12 20 20 CD cord-010119-t1x9gknd 9877 13 days day NNS cord-010119-t1x9gknd 9877 14 . . . cord-010119-t1x9gknd 9878 1 The the DT cord-010119-t1x9gknd 9878 2 blood blood NN cord-010119-t1x9gknd 9878 3 donor donor NN cord-010119-t1x9gknd 9878 4 specificity specificity NN cord-010119-t1x9gknd 9878 5 was be VBD cord-010119-t1x9gknd 9878 6 99.96 99.96 CD cord-010119-t1x9gknd 9878 7 % % NN cord-010119-t1x9gknd 9878 8 ( ( -LRB- cord-010119-t1x9gknd 9878 9 8082/8085 8082/8085 CD cord-010119-t1x9gknd 9878 10 ) ) -RRB- cord-010119-t1x9gknd 9878 11 . . . cord-010119-t1x9gknd 9879 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9879 2 was be VBD cord-010119-t1x9gknd 9879 3 100 100 CD cord-010119-t1x9gknd 9879 4 % % NN cord-010119-t1x9gknd 9879 5 for for IN cord-010119-t1x9gknd 9879 6 813 813 CD cord-010119-t1x9gknd 9879 7 presumed presume VBN cord-010119-t1x9gknd 9879 8 antibody antibody NN cord-010119-t1x9gknd 9879 9 positive positive JJ cord-010119-t1x9gknd 9879 10 samples sample NNS cord-010119-t1x9gknd 9879 11 comprised comprise VBN cord-010119-t1x9gknd 9879 12 of of IN cord-010119-t1x9gknd 9879 13 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9879 14 , , , cord-010119-t1x9gknd 9879 15 HIV-2 HIV-2 NNP cord-010119-t1x9gknd 9879 16 and and CC cord-010119-t1x9gknd 9879 17 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9879 18 Groups Groups NNPS cord-010119-t1x9gknd 9879 19 O O NNP cord-010119-t1x9gknd 9879 20 , , , cord-010119-t1x9gknd 9879 21 N N NNP cord-010119-t1x9gknd 9879 22 , , , cord-010119-t1x9gknd 9879 23 P P NNP cord-010119-t1x9gknd 9879 24 , , , cord-010119-t1x9gknd 9879 25 CRF CRF NNP cord-010119-t1x9gknd 9879 26 and and CC cord-010119-t1x9gknd 9879 27 URF URF NNP cord-010119-t1x9gknd 9879 28 samples sample NNS cord-010119-t1x9gknd 9879 29 . . . cord-010119-t1x9gknd 9880 1 Also also RB cord-010119-t1x9gknd 9880 2 , , , cord-010119-t1x9gknd 9880 3 sensitivity sensitivity NN cord-010119-t1x9gknd 9880 4 was be VBD cord-010119-t1x9gknd 9880 5 100 100 CD cord-010119-t1x9gknd 9880 6 % % NN cord-010119-t1x9gknd 9880 7 for for IN cord-010119-t1x9gknd 9880 8 102 102 CD cord-010119-t1x9gknd 9880 9 antigen antigen NN cord-010119-t1x9gknd 9880 10 positive positive JJ cord-010119-t1x9gknd 9880 11 viral viral JJ cord-010119-t1x9gknd 9880 12 isolate isolate NN cord-010119-t1x9gknd 9880 13 samples sample NNS cord-010119-t1x9gknd 9880 14 comprised comprise VBN cord-010119-t1x9gknd 9880 15 of of IN cord-010119-t1x9gknd 9880 16 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9880 17 , , , cord-010119-t1x9gknd 9880 18 HIV-2 HIV-2 NNP cord-010119-t1x9gknd 9880 19 and and CC cord-010119-t1x9gknd 9880 20 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 9880 21 Groups Groups NNPS cord-010119-t1x9gknd 9880 22 O O NNP cord-010119-t1x9gknd 9880 23 , , , cord-010119-t1x9gknd 9880 24 N N NNP cord-010119-t1x9gknd 9880 25 , , , cord-010119-t1x9gknd 9880 26 P P NNP cord-010119-t1x9gknd 9880 27 , , , cord-010119-t1x9gknd 9880 28 CRF CRF NNP cord-010119-t1x9gknd 9880 29 and and CC cord-010119-t1x9gknd 9880 30 URF URF NNP cord-010119-t1x9gknd 9880 31 samples sample NNS cord-010119-t1x9gknd 9880 32 . . . cord-010119-t1x9gknd 9881 1 Seroconversion seroconversion NN cord-010119-t1x9gknd 9881 2 detection detection NN cord-010119-t1x9gknd 9881 3 was be VBD cord-010119-t1x9gknd 9881 4 equivalent equivalent JJ cord-010119-t1x9gknd 9881 5 to to IN cord-010119-t1x9gknd 9881 6 the the DT cord-010119-t1x9gknd 9881 7 comparator comparator NN cord-010119-t1x9gknd 9881 8 assay assay NN cord-010119-t1x9gknd 9881 9 with with IN cord-010119-t1x9gknd 9881 10 136 136 CD cord-010119-t1x9gknd 9881 11 reactive reactive JJ cord-010119-t1x9gknd 9881 12 samples sample NNS cord-010119-t1x9gknd 9881 13 detected detect VBN cord-010119-t1x9gknd 9881 14 with with IN cord-010119-t1x9gknd 9881 15 the the DT cord-010119-t1x9gknd 9881 16 Alinity Alinity NNP cord-010119-t1x9gknd 9881 17 s s POS cord-010119-t1x9gknd 9881 18 assay assay NN cord-010119-t1x9gknd 9881 19 and and CC cord-010119-t1x9gknd 9881 20 135 135 CD cord-010119-t1x9gknd 9881 21 reactive reactive JJ cord-010119-t1x9gknd 9881 22 samples sample NNS cord-010119-t1x9gknd 9881 23 detected detect VBN cord-010119-t1x9gknd 9881 24 by by IN cord-010119-t1x9gknd 9881 25 the the DT cord-010119-t1x9gknd 9881 26 comparator comparator NN cord-010119-t1x9gknd 9881 27 assay assay NN cord-010119-t1x9gknd 9881 28 . . . cord-010119-t1x9gknd 9882 1 Conclusion conclusion NN cord-010119-t1x9gknd 9882 2 : : : cord-010119-t1x9gknd 9883 1 These these DT cord-010119-t1x9gknd 9883 2 results result NNS cord-010119-t1x9gknd 9883 3 indicate indicate VBP cord-010119-t1x9gknd 9883 4 that that IN cord-010119-t1x9gknd 9883 5 the the DT cord-010119-t1x9gknd 9883 6 new new JJ cord-010119-t1x9gknd 9883 7 automated automate VBN cord-010119-t1x9gknd 9883 8 Alinity Alinity NNP cord-010119-t1x9gknd 9883 9 s s POS cord-010119-t1x9gknd 9883 10 HIV HIV NNP cord-010119-t1x9gknd 9883 11 Ag Ag NNP cord-010119-t1x9gknd 9883 12 / / SYM cord-010119-t1x9gknd 9883 13 Ab Ab NNP cord-010119-t1x9gknd 9883 14 Combo Combo NNP cord-010119-t1x9gknd 9883 15 assay assay NN cord-010119-t1x9gknd 9883 16 provided provide VBD cord-010119-t1x9gknd 9883 17 acceptable acceptable JJ cord-010119-t1x9gknd 9883 18 performance performance NN cord-010119-t1x9gknd 9883 19 in in IN cord-010119-t1x9gknd 9883 20 specificity specificity NN cord-010119-t1x9gknd 9883 21 , , , cord-010119-t1x9gknd 9883 22 sensitivity sensitivity NN cord-010119-t1x9gknd 9883 23 and and CC cord-010119-t1x9gknd 9883 24 precision precision NN cord-010119-t1x9gknd 9883 25 , , , cord-010119-t1x9gknd 9883 26 while while IN cord-010119-t1x9gknd 9883 27 providing provide VBG cord-010119-t1x9gknd 9883 28 similar similar JJ cord-010119-t1x9gknd 9883 29 seroconversion seroconversion NN cord-010119-t1x9gknd 9883 30 sensitivity sensitivity NN cord-010119-t1x9gknd 9883 31 as as IN cord-010119-t1x9gknd 9883 32 the the DT cord-010119-t1x9gknd 9883 33 comparator comparator NN cord-010119-t1x9gknd 9883 34 assay assay NN cord-010119-t1x9gknd 9883 35 . . . cord-010119-t1x9gknd 9884 1 Performance performance NN cord-010119-t1x9gknd 9884 2 of of IN cord-010119-t1x9gknd 9884 3 a a DT cord-010119-t1x9gknd 9884 4 New New NNP cord-010119-t1x9gknd 9884 5 Automated Automated NNP cord-010119-t1x9gknd 9884 6 Alinity Alinity NNP cord-010119-t1x9gknd 9884 7 s s NN cord-010119-t1x9gknd 9884 8 Immunoassay Immunoassay NNP cord-010119-t1x9gknd 9884 9 for for IN cord-010119-t1x9gknd 9884 10 the the DT cord-010119-t1x9gknd 9884 11 Detection Detection NNP cord-010119-t1x9gknd 9884 12 of of IN cord-010119-t1x9gknd 9884 13 Anti Anti NNP cord-010119-t1x9gknd 9884 14 - - JJ cord-010119-t1x9gknd 9884 15 HBc HBc NNP cord-010119-t1x9gknd 9884 16 Antibodies Antibodies NNP cord-010119-t1x9gknd 9884 17 Randal Randal NNP cord-010119-t1x9gknd 9884 18 Makela Makela NNP cord-010119-t1x9gknd 9884 19 * * NFP cord-010119-t1x9gknd 9884 20 1 1 CD cord-010119-t1x9gknd 9884 21 , , , cord-010119-t1x9gknd 9884 22 Anton Anton NNP cord-010119-t1x9gknd 9884 23 vanWeert vanWeert NNP cord-010119-t1x9gknd 9884 24 2 2 CD cord-010119-t1x9gknd 9884 25 , , , cord-010119-t1x9gknd 9884 26 Ed Ed NNP cord-010119-t1x9gknd 9884 27 Bakker Bakker NNP cord-010119-t1x9gknd 9884 28 2 2 CD cord-010119-t1x9gknd 9884 29 , , , cord-010119-t1x9gknd 9884 30 Jane Jane NNP cord-010119-t1x9gknd 9884 31 Bryant Bryant NNP cord-010119-t1x9gknd 9884 32 1 1 CD cord-010119-t1x9gknd 9884 33 , , , cord-010119-t1x9gknd 9884 34 Mark Mark NNP cord-010119-t1x9gknd 9884 35 Paradowski Paradowski NNP cord-010119-t1x9gknd 9884 36 1 1 CD cord-010119-t1x9gknd 9884 37 , , , cord-010119-t1x9gknd 9884 38 Joyce Joyce NNP cord-010119-t1x9gknd 9884 39 Siregar Siregar NNP cord-010119-t1x9gknd 9884 40 1 1 CD cord-010119-t1x9gknd 9884 41 , , , cord-010119-t1x9gknd 9884 42 Angela Angela NNP cord-010119-t1x9gknd 9884 43 Vockel Vockel NNP cord-010119-t1x9gknd 9884 44 3 3 CD cord-010119-t1x9gknd 9884 45 , , , cord-010119-t1x9gknd 9884 46 George George NNP cord-010119-t1x9gknd 9884 47 Chen Chen NNP cord-010119-t1x9gknd 9884 48 1 1 CD cord-010119-t1x9gknd 9884 49 , , , cord-010119-t1x9gknd 9884 50 Gregg Gregg NNP cord-010119-t1x9gknd 9884 51 Williams Williams NNP cord-010119-t1x9gknd 9884 52 1 1 CD cord-010119-t1x9gknd 9884 53 and and CC cord-010119-t1x9gknd 9884 54 George George NNP cord-010119-t1x9gknd 9884 55 Schlauder Schlauder NNP cord-010119-t1x9gknd 9884 56 4 4 CD cord-010119-t1x9gknd 9884 57 . . . cord-010119-t1x9gknd 9885 1 1 1 LS cord-010119-t1x9gknd 9886 1 Abbott Abbott NNP cord-010119-t1x9gknd 9886 2 Laboratories Laboratories NNP cord-010119-t1x9gknd 9886 3 , , , cord-010119-t1x9gknd 9886 4 2 2 CD cord-010119-t1x9gknd 9886 5 Sanguin Sanguin NNP cord-010119-t1x9gknd 9886 6 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 9886 7 , , , cord-010119-t1x9gknd 9886 8 3 3 CD cord-010119-t1x9gknd 9886 9 Abbott Abbott NNP cord-010119-t1x9gknd 9886 10 GmbH GmbH NNP cord-010119-t1x9gknd 9886 11 & & CC cord-010119-t1x9gknd 9886 12 Co. Co. NNP cord-010119-t1x9gknd 9886 13 KG KG NNP cord-010119-t1x9gknd 9886 14 , , , cord-010119-t1x9gknd 9886 15 4 4 CD cord-010119-t1x9gknd 9886 16 Abbott Abbott NNP cord-010119-t1x9gknd 9886 17 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9886 18 Background Background NNP cord-010119-t1x9gknd 9886 19 / / SYM cord-010119-t1x9gknd 9886 20 Case Case NNP cord-010119-t1x9gknd 9886 21 Studies Studies NNPS cord-010119-t1x9gknd 9886 22 : : : cord-010119-t1x9gknd 9887 1 In in IN cord-010119-t1x9gknd 9887 2 countries country NNS cord-010119-t1x9gknd 9887 3 with with IN cord-010119-t1x9gknd 9887 4 a a DT cord-010119-t1x9gknd 9887 5 low low JJ cord-010119-t1x9gknd 9887 6 prevalence prevalence NN cord-010119-t1x9gknd 9887 7 of of IN cord-010119-t1x9gknd 9887 8 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 9887 9 B B NNP cord-010119-t1x9gknd 9887 10 , , , cord-010119-t1x9gknd 9887 11 blood blood NN cord-010119-t1x9gknd 9887 12 donations donation NNS cord-010119-t1x9gknd 9887 13 are be VBP cord-010119-t1x9gknd 9887 14 commonly commonly RB cord-010119-t1x9gknd 9887 15 screened screen VBN cord-010119-t1x9gknd 9887 16 to to TO cord-010119-t1x9gknd 9887 17 detect detect VB cord-010119-t1x9gknd 9887 18 the the DT cord-010119-t1x9gknd 9887 19 presence presence NN cord-010119-t1x9gknd 9887 20 of of IN cord-010119-t1x9gknd 9887 21 antibodies antibody NNS cord-010119-t1x9gknd 9887 22 to to IN cord-010119-t1x9gknd 9887 23 hepatitis hepatitis NNP cord-010119-t1x9gknd 9887 24 B B NNP cord-010119-t1x9gknd 9887 25 core core NN cord-010119-t1x9gknd 9887 26 antigen antigen NN cord-010119-t1x9gknd 9887 27 ( ( -LRB- cord-010119-t1x9gknd 9887 28 Anti Anti NNP cord-010119-t1x9gknd 9887 29 - - NNP cord-010119-t1x9gknd 9887 30 HBc HBc NNP cord-010119-t1x9gknd 9887 31 ) ) -RRB- cord-010119-t1x9gknd 9887 32 alongside alongside IN cord-010119-t1x9gknd 9887 33 HBsAg HBsAg NNP cord-010119-t1x9gknd 9887 34 and and CC cord-010119-t1x9gknd 9887 35 HBV HBV NNP cord-010119-t1x9gknd 9887 36 NAT NAT NNP cord-010119-t1x9gknd 9887 37 to to TO cord-010119-t1x9gknd 9887 38 detect detect VB cord-010119-t1x9gknd 9887 39 donors donor NNS cord-010119-t1x9gknd 9887 40 with with IN cord-010119-t1x9gknd 9887 41 occult occult JJ cord-010119-t1x9gknd 9887 42 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 9887 43 B B NNP cord-010119-t1x9gknd 9887 44 infections infection NNS cord-010119-t1x9gknd 9887 45 ( ( -LRB- cord-010119-t1x9gknd 9887 46 OBI OBI NNP cord-010119-t1x9gknd 9887 47 ) ) -RRB- cord-010119-t1x9gknd 9887 48 . . . cord-010119-t1x9gknd 9888 1 Blood blood NN cord-010119-t1x9gknd 9888 2 centers center NNS cord-010119-t1x9gknd 9888 3 require require VBP cord-010119-t1x9gknd 9888 4 anti anti JJ cord-010119-t1x9gknd 9888 5 - - JJ cord-010119-t1x9gknd 9888 6 HBc hbc JJ cord-010119-t1x9gknd 9888 7 assays assay NNS cord-010119-t1x9gknd 9888 8 with with IN cord-010119-t1x9gknd 9888 9 high high JJ cord-010119-t1x9gknd 9888 10 specificity specificity NN cord-010119-t1x9gknd 9888 11 and and CC cord-010119-t1x9gknd 9888 12 sensitivity sensitivity NN cord-010119-t1x9gknd 9888 13 to to TO cord-010119-t1x9gknd 9888 14 prevent prevent VB cord-010119-t1x9gknd 9888 15 unnecessary unnecessary JJ cord-010119-t1x9gknd 9888 16 donor donor NN cord-010119-t1x9gknd 9888 17 deferrals deferral NNS cord-010119-t1x9gknd 9888 18 while while IN cord-010119-t1x9gknd 9888 19 maintaining maintain VBG cord-010119-t1x9gknd 9888 20 a a DT cord-010119-t1x9gknd 9888 21 safe safe JJ cord-010119-t1x9gknd 9888 22 blood blood NN cord-010119-t1x9gknd 9888 23 supply supply NN cord-010119-t1x9gknd 9888 24 . . . cord-010119-t1x9gknd 9889 1 In in IN cord-010119-t1x9gknd 9889 2 addition addition NN cord-010119-t1x9gknd 9889 3 , , , cord-010119-t1x9gknd 9889 4 continued continue VBN cord-010119-t1x9gknd 9889 5 pressures pressure NNS cord-010119-t1x9gknd 9889 6 on on IN cord-010119-t1x9gknd 9889 7 laboratory laboratory NN cord-010119-t1x9gknd 9889 8 operations operation NNS cord-010119-t1x9gknd 9889 9 demand demand VBP cord-010119-t1x9gknd 9889 10 that that IN cord-010119-t1x9gknd 9889 11 assays assay NNS cord-010119-t1x9gknd 9889 12 perform perform VBP cord-010119-t1x9gknd 9889 13 on on IN cord-010119-t1x9gknd 9889 14 platforms platform NNS cord-010119-t1x9gknd 9889 15 capable capable JJ cord-010119-t1x9gknd 9889 16 of of IN cord-010119-t1x9gknd 9889 17 increased increase VBN cord-010119-t1x9gknd 9889 18 walk walk NN cord-010119-t1x9gknd 9889 19 away away RB cord-010119-t1x9gknd 9889 20 time time NN cord-010119-t1x9gknd 9889 21 and and CC cord-010119-t1x9gknd 9889 22 enhanced enhanced JJ cord-010119-t1x9gknd 9889 23 automation automation NN cord-010119-t1x9gknd 9889 24 in in IN cord-010119-t1x9gknd 9889 25 areas area NNS cord-010119-t1x9gknd 9889 26 of of IN cord-010119-t1x9gknd 9889 27 reagent reagent NN cord-010119-t1x9gknd 9889 28 management management NN cord-010119-t1x9gknd 9889 29 , , , cord-010119-t1x9gknd 9889 30 retest retest VB cord-010119-t1x9gknd 9889 31 options option NNS cord-010119-t1x9gknd 9889 32 , , , cord-010119-t1x9gknd 9889 33 and and CC cord-010119-t1x9gknd 9889 34 commodity commodity NN cord-010119-t1x9gknd 9889 35 / / SYM cord-010119-t1x9gknd 9889 36 waste waste NN cord-010119-t1x9gknd 9889 37 management management NN cord-010119-t1x9gknd 9889 38 . . . cord-010119-t1x9gknd 9890 1 In in IN cord-010119-t1x9gknd 9890 2 the the DT cord-010119-t1x9gknd 9890 3 response response NN cord-010119-t1x9gknd 9890 4 for for IN cord-010119-t1x9gknd 9890 5 the the DT cord-010119-t1x9gknd 9890 6 need need NN cord-010119-t1x9gknd 9890 7 for for IN cord-010119-t1x9gknd 9890 8 such such JJ cord-010119-t1x9gknd 9890 9 screening screening NN cord-010119-t1x9gknd 9890 10 assays assay NNS cord-010119-t1x9gknd 9890 11 , , , cord-010119-t1x9gknd 9890 12 we -PRON- PRP cord-010119-t1x9gknd 9890 13 have have VBP cord-010119-t1x9gknd 9890 14 developed develop VBN cord-010119-t1x9gknd 9890 15 an an DT cord-010119-t1x9gknd 9890 16 improved improved JJ cord-010119-t1x9gknd 9890 17 automated automated JJ cord-010119-t1x9gknd 9890 18 assay assay NN cord-010119-t1x9gknd 9890 19 for for IN cord-010119-t1x9gknd 9890 20 the the DT cord-010119-t1x9gknd 9890 21 detection detection NN cord-010119-t1x9gknd 9890 22 of of IN cord-010119-t1x9gknd 9890 23 anti anti JJ cord-010119-t1x9gknd 9890 24 - - JJ cord-010119-t1x9gknd 9890 25 HBc HBc NNP cord-010119-t1x9gknd 9890 26 on on IN cord-010119-t1x9gknd 9890 27 the the DT cord-010119-t1x9gknd 9890 28 Alinity Alinity NNP cord-010119-t1x9gknd 9890 29 s s POS cord-010119-t1x9gknd 9890 30 System System NNP cord-010119-t1x9gknd 9890 31 . . . cord-010119-t1x9gknd 9891 1 Study Study NNP cord-010119-t1x9gknd 9891 2 Design Design NNP cord-010119-t1x9gknd 9891 3 / / SYM cord-010119-t1x9gknd 9891 4 Method method NN cord-010119-t1x9gknd 9891 5 : : : cord-010119-t1x9gknd 9892 1 The the DT cord-010119-t1x9gknd 9892 2 performance performance NN cord-010119-t1x9gknd 9892 3 of of IN cord-010119-t1x9gknd 9892 4 a a DT cord-010119-t1x9gknd 9892 5 new new JJ cord-010119-t1x9gknd 9892 6 chemiluminescence chemiluminescence NN cord-010119-t1x9gknd 9892 7 anti anti JJ cord-010119-t1x9gknd 9892 8 - - JJ cord-010119-t1x9gknd 9892 9 HBc hbc JJ cord-010119-t1x9gknd 9892 10 assay assay NN cord-010119-t1x9gknd 9892 11 for for IN cord-010119-t1x9gknd 9892 12 the the DT cord-010119-t1x9gknd 9892 13 detection detection NN cord-010119-t1x9gknd 9892 14 of of IN cord-010119-t1x9gknd 9892 15 anti anti JJ cord-010119-t1x9gknd 9892 16 - - JJ cord-010119-t1x9gknd 9892 17 HBc hbc JJ cord-010119-t1x9gknd 9892 18 antibodies antibody NNS cord-010119-t1x9gknd 9892 19 was be VBD cord-010119-t1x9gknd 9892 20 evaluated evaluate VBN cord-010119-t1x9gknd 9892 21 on on IN cord-010119-t1x9gknd 9892 22 the the DT cord-010119-t1x9gknd 9892 23 next next JJ cord-010119-t1x9gknd 9892 24 generation generation NN cord-010119-t1x9gknd 9892 25 automated automate VBD cord-010119-t1x9gknd 9892 26 Abbott Abbott NNP cord-010119-t1x9gknd 9892 27 Alinity Alinity NNP cord-010119-t1x9gknd 9892 28 s s POS cord-010119-t1x9gknd 9892 29 System System NNP cord-010119-t1x9gknd 9892 30 . . . cord-010119-t1x9gknd 9893 1 Precision precision NN cord-010119-t1x9gknd 9893 2 was be VBD cord-010119-t1x9gknd 9893 3 assessed assess VBN cord-010119-t1x9gknd 9893 4 over over IN cord-010119-t1x9gknd 9893 5 20 20 CD cord-010119-t1x9gknd 9893 6 days day NNS cord-010119-t1x9gknd 9893 7 evaluating evaluate VBG cord-010119-t1x9gknd 9893 8 positive positive JJ cord-010119-t1x9gknd 9893 9 samples sample NNS cord-010119-t1x9gknd 9893 10 . . . cord-010119-t1x9gknd 9894 1 Specificity specificity NN cord-010119-t1x9gknd 9894 2 was be VBD cord-010119-t1x9gknd 9894 3 evaluated evaluate VBN cord-010119-t1x9gknd 9894 4 on on IN cord-010119-t1x9gknd 9894 5 samples sample NNS cord-010119-t1x9gknd 9894 6 obtained obtain VBN cord-010119-t1x9gknd 9894 7 from from IN cord-010119-t1x9gknd 9894 8 random random JJ cord-010119-t1x9gknd 9894 9 blood blood NN cord-010119-t1x9gknd 9894 10 donors donor NNS cord-010119-t1x9gknd 9894 11 . . . cord-010119-t1x9gknd 9895 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9895 2 was be VBD cord-010119-t1x9gknd 9895 3 evaluated evaluate VBN cord-010119-t1x9gknd 9895 4 using use VBG cord-010119-t1x9gknd 9895 5 specimens specimen NNS cord-010119-t1x9gknd 9895 6 characterized characterize VBN cord-010119-t1x9gknd 9895 7 as as IN cord-010119-t1x9gknd 9895 8 anti anti JJ cord-010119-t1x9gknd 9895 9 - - JJ cord-010119-t1x9gknd 9895 10 HBc hbc JJ cord-010119-t1x9gknd 9895 11 positive positive JJ cord-010119-t1x9gknd 9895 12 by by IN cord-010119-t1x9gknd 9895 13 means mean NNS cord-010119-t1x9gknd 9895 14 of of IN cord-010119-t1x9gknd 9895 15 serologic serologic JJ cord-010119-t1x9gknd 9895 16 methods method NNS cord-010119-t1x9gknd 9895 17 . . . cord-010119-t1x9gknd 9896 1 Analytical analytical JJ cord-010119-t1x9gknd 9896 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9896 3 was be VBD cord-010119-t1x9gknd 9896 4 assessed assess VBN cord-010119-t1x9gknd 9896 5 using use VBG cord-010119-t1x9gknd 9896 6 the the DT cord-010119-t1x9gknd 9896 7 WHO WHO NNP cord-010119-t1x9gknd 9896 8 1st 1st NN cord-010119-t1x9gknd 9896 9 International international JJ cord-010119-t1x9gknd 9896 10 standard standard NN cord-010119-t1x9gknd 9896 11 . . . cord-010119-t1x9gknd 9897 1 Seroconversion seroconversion NN cord-010119-t1x9gknd 9897 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9897 3 was be VBD cord-010119-t1x9gknd 9897 4 evaluated evaluate VBN cord-010119-t1x9gknd 9897 5 using use VBG cord-010119-t1x9gknd 9897 6 10 10 CD cord-010119-t1x9gknd 9897 7 commercial commercial JJ cord-010119-t1x9gknd 9897 8 seroconversion seroconversion NN cord-010119-t1x9gknd 9897 9 panels panel NNS cord-010119-t1x9gknd 9897 10 . . . cord-010119-t1x9gknd 9898 1 Results/ Results/ . cord-010119-t1x9gknd 9899 1 Finding finding NN cord-010119-t1x9gknd 9899 2 : : : cord-010119-t1x9gknd 9900 1 Precision precision NN cord-010119-t1x9gknd 9900 2 was be VBD cord-010119-t1x9gknd 9900 3 less less JJR cord-010119-t1x9gknd 9900 4 than than IN cord-010119-t1x9gknd 9900 5 6 6 CD cord-010119-t1x9gknd 9900 6 % % NN cord-010119-t1x9gknd 9900 7 CV cv NN cord-010119-t1x9gknd 9900 8 for for IN cord-010119-t1x9gknd 9900 9 positive positive JJ cord-010119-t1x9gknd 9900 10 samples sample NNS cord-010119-t1x9gknd 9900 11 over over IN cord-010119-t1x9gknd 9900 12 20 20 CD cord-010119-t1x9gknd 9900 13 days day NNS cord-010119-t1x9gknd 9900 14 . . . cord-010119-t1x9gknd 9901 1 The the DT cord-010119-t1x9gknd 9901 2 blood blood NN cord-010119-t1x9gknd 9901 3 donor donor NN cord-010119-t1x9gknd 9901 4 specificity specificity NN cord-010119-t1x9gknd 9901 5 was be VBD cord-010119-t1x9gknd 9901 6 99.93 99.93 CD cord-010119-t1x9gknd 9901 7 % % NN cord-010119-t1x9gknd 9901 8 ( ( -LRB- cord-010119-t1x9gknd 9901 9 6946/6951 6946/6951 CD cord-010119-t1x9gknd 9901 10 ) ) -RRB- cord-010119-t1x9gknd 9901 11 . . . cord-010119-t1x9gknd 9902 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9902 2 was be VBD cord-010119-t1x9gknd 9902 3 100 100 CD cord-010119-t1x9gknd 9902 4 % % NN cord-010119-t1x9gknd 9902 5 for for IN cord-010119-t1x9gknd 9902 6 500 500 CD cord-010119-t1x9gknd 9902 7 samples sample NNS cord-010119-t1x9gknd 9902 8 presumed presume VBN cord-010119-t1x9gknd 9902 9 to to TO cord-010119-t1x9gknd 9902 10 be be VB cord-010119-t1x9gknd 9902 11 anti anti JJ cord-010119-t1x9gknd 9902 12 - - JJ cord-010119-t1x9gknd 9902 13 HBc hbc JJ cord-010119-t1x9gknd 9902 14 positive positive JJ cord-010119-t1x9gknd 9902 15 . . . cord-010119-t1x9gknd 9903 1 Analytical analytical JJ cord-010119-t1x9gknd 9903 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9903 3 results result NNS cord-010119-t1x9gknd 9903 4 on on IN cord-010119-t1x9gknd 9903 5 the the DT cord-010119-t1x9gknd 9903 6 Alinity Alinity NNP cord-010119-t1x9gknd 9903 7 s s POS cord-010119-t1x9gknd 9903 8 Anti Anti NNP cord-010119-t1x9gknd 9903 9 - - JJ cord-010119-t1x9gknd 9903 10 HBc hbc JJ cord-010119-t1x9gknd 9903 11 assay assay NN cord-010119-t1x9gknd 9903 12 ranged range VBD cord-010119-t1x9gknd 9903 13 from from IN cord-010119-t1x9gknd 9903 14 0.57 0.57 CD cord-010119-t1x9gknd 9903 15 to to IN cord-010119-t1x9gknd 9903 16 0.62 0.62 CD cord-010119-t1x9gknd 9903 17 IU IU NNP cord-010119-t1x9gknd 9903 18 / / SYM cord-010119-t1x9gknd 9903 19 mL. mL. NNS cord-010119-t1x9gknd 9903 20 Seroconversion Seroconversion NNP cord-010119-t1x9gknd 9903 21 detection detection NN cord-010119-t1x9gknd 9903 22 was be VBD cord-010119-t1x9gknd 9903 23 equivalent equivalent JJ cord-010119-t1x9gknd 9903 24 to to IN cord-010119-t1x9gknd 9903 25 the the DT cord-010119-t1x9gknd 9903 26 comparator comparator NN cord-010119-t1x9gknd 9903 27 assay assay NN cord-010119-t1x9gknd 9903 28 with with IN cord-010119-t1x9gknd 9903 29 136 136 CD cord-010119-t1x9gknd 9903 30 reactive reactive JJ cord-010119-t1x9gknd 9903 31 samples sample NNS cord-010119-t1x9gknd 9903 32 detected detect VBN cord-010119-t1x9gknd 9903 33 with with IN cord-010119-t1x9gknd 9903 34 the the DT cord-010119-t1x9gknd 9903 35 Alinity Alinity NNP cord-010119-t1x9gknd 9903 36 s s POS cord-010119-t1x9gknd 9903 37 assay assay NN cord-010119-t1x9gknd 9903 38 and and CC cord-010119-t1x9gknd 9903 39 134 134 CD cord-010119-t1x9gknd 9903 40 reactive reactive JJ cord-010119-t1x9gknd 9903 41 samples sample NNS cord-010119-t1x9gknd 9903 42 detected detect VBN cord-010119-t1x9gknd 9903 43 by by IN cord-010119-t1x9gknd 9903 44 the the DT cord-010119-t1x9gknd 9903 45 comparator comparator NN cord-010119-t1x9gknd 9903 46 assay assay NN cord-010119-t1x9gknd 9903 47 . . . cord-010119-t1x9gknd 9904 1 Conclusion conclusion NN cord-010119-t1x9gknd 9904 2 : : : cord-010119-t1x9gknd 9905 1 These these DT cord-010119-t1x9gknd 9905 2 results result NNS cord-010119-t1x9gknd 9905 3 indicate indicate VBP cord-010119-t1x9gknd 9905 4 that that IN cord-010119-t1x9gknd 9905 5 the the DT cord-010119-t1x9gknd 9905 6 new new JJ cord-010119-t1x9gknd 9905 7 automated automate VBN cord-010119-t1x9gknd 9905 8 Alinity Alinity NNP cord-010119-t1x9gknd 9905 9 s s POS cord-010119-t1x9gknd 9905 10 Anti Anti NNP cord-010119-t1x9gknd 9905 11 - - JJ cord-010119-t1x9gknd 9905 12 HBc hbc JJ cord-010119-t1x9gknd 9905 13 assay assay NN cord-010119-t1x9gknd 9905 14 provided provide VBD cord-010119-t1x9gknd 9905 15 good good JJ cord-010119-t1x9gknd 9905 16 performance performance NN cord-010119-t1x9gknd 9905 17 in in IN cord-010119-t1x9gknd 9905 18 specificity specificity NN cord-010119-t1x9gknd 9905 19 , , , cord-010119-t1x9gknd 9905 20 sensitivity sensitivity NN cord-010119-t1x9gknd 9905 21 and and CC cord-010119-t1x9gknd 9905 22 precision precision NN cord-010119-t1x9gknd 9905 23 versus versus IN cord-010119-t1x9gknd 9905 24 the the DT cord-010119-t1x9gknd 9905 25 comparator comparator NN cord-010119-t1x9gknd 9905 26 assay assay NN cord-010119-t1x9gknd 9905 27 . . . cord-010119-t1x9gknd 9906 1 Performance performance NN cord-010119-t1x9gknd 9906 2 of of IN cord-010119-t1x9gknd 9906 3 a a DT cord-010119-t1x9gknd 9906 4 New New NNP cord-010119-t1x9gknd 9906 5 Automated Automated NNP cord-010119-t1x9gknd 9906 6 Alinity Alinity NNP cord-010119-t1x9gknd 9906 7 s s NN cord-010119-t1x9gknd 9906 8 Immunoassay Immunoassay NNP cord-010119-t1x9gknd 9906 9 for for IN cord-010119-t1x9gknd 9906 10 the the DT cord-010119-t1x9gknd 9906 11 Detection detection NN cord-010119-t1x9gknd 9906 12 of of IN cord-010119-t1x9gknd 9906 13 HTLV HTLV NNP cord-010119-t1x9gknd 9906 14 I I NNP cord-010119-t1x9gknd 9906 15 and and CC cord-010119-t1x9gknd 9906 16 HTLV HTLV NNP cord-010119-t1x9gknd 9906 17 II II NNP cord-010119-t1x9gknd 9906 18 Antibodies Antibodies NNP cord-010119-t1x9gknd 9907 1 Melanie Melanie NNP cord-010119-t1x9gknd 9907 2 Anderson Anderson NNP cord-010119-t1x9gknd 9907 3 * * NFP cord-010119-t1x9gknd 9907 4 1 1 CD cord-010119-t1x9gknd 9907 5 , , , cord-010119-t1x9gknd 9907 6 Anton Anton NNP cord-010119-t1x9gknd 9907 7 vanWeert vanWeert NNP cord-010119-t1x9gknd 9907 8 2 2 CD cord-010119-t1x9gknd 9907 9 , , , cord-010119-t1x9gknd 9907 10 Ed Ed NNP cord-010119-t1x9gknd 9907 11 Bakker Bakker NNP cord-010119-t1x9gknd 9907 12 2 2 CD cord-010119-t1x9gknd 9907 13 , , , cord-010119-t1x9gknd 9907 14 Mark Mark NNP cord-010119-t1x9gknd 9907 15 Paradowski Paradowski NNP cord-010119-t1x9gknd 9907 16 1 1 CD cord-010119-t1x9gknd 9907 17 , , , cord-010119-t1x9gknd 9907 18 Jane Jane NNP cord-010119-t1x9gknd 9907 19 Bryant Bryant NNP cord-010119-t1x9gknd 9907 20 1 1 CD cord-010119-t1x9gknd 9907 21 , , , cord-010119-t1x9gknd 9907 22 Tuan Tuan NNP cord-010119-t1x9gknd 9907 23 Bui Bui NNP cord-010119-t1x9gknd 9907 24 1 1 CD cord-010119-t1x9gknd 9907 25 , , , cord-010119-t1x9gknd 9907 26 Joyce Joyce NNP cord-010119-t1x9gknd 9907 27 Siregar Siregar NNP cord-010119-t1x9gknd 9907 28 1 1 CD cord-010119-t1x9gknd 9907 29 , , , cord-010119-t1x9gknd 9907 30 George George NNP cord-010119-t1x9gknd 9907 31 Chen Chen NNP cord-010119-t1x9gknd 9907 32 1 1 CD cord-010119-t1x9gknd 9907 33 , , , cord-010119-t1x9gknd 9907 34 George George NNP cord-010119-t1x9gknd 9907 35 Schlauder Schlauder NNP cord-010119-t1x9gknd 9907 36 3 3 NNP cord-010119-t1x9gknd 9907 37 and and CC cord-010119-t1x9gknd 9907 38 Gregg Gregg NNP cord-010119-t1x9gknd 9907 39 Williams Williams NNP cord-010119-t1x9gknd 9907 40 1 1 CD cord-010119-t1x9gknd 9907 41 . . . cord-010119-t1x9gknd 9908 1 1 1 LS cord-010119-t1x9gknd 9909 1 Abbott Abbott NNP cord-010119-t1x9gknd 9909 2 Laboratories Laboratories NNP cord-010119-t1x9gknd 9909 3 , , , cord-010119-t1x9gknd 9909 4 2 2 CD cord-010119-t1x9gknd 9909 5 Sanguin Sanguin NNP cord-010119-t1x9gknd 9909 6 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 9909 7 , , , cord-010119-t1x9gknd 9909 8 3 3 CD cord-010119-t1x9gknd 9909 9 Abbott Abbott NNP cord-010119-t1x9gknd 9909 10 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9909 11 Background Background NNP cord-010119-t1x9gknd 9909 12 / / SYM cord-010119-t1x9gknd 9909 13 Case Case NNP cord-010119-t1x9gknd 9909 14 Studies Studies NNPS cord-010119-t1x9gknd 9909 15 : : : cord-010119-t1x9gknd 9910 1 In in IN cord-010119-t1x9gknd 9910 2 endemic endemic JJ cord-010119-t1x9gknd 9910 3 countries country NNS cord-010119-t1x9gknd 9910 4 , , , cord-010119-t1x9gknd 9910 5 universal universal JJ cord-010119-t1x9gknd 9910 6 blood blood NN cord-010119-t1x9gknd 9910 7 screening screening NN cord-010119-t1x9gknd 9910 8 is be VBZ cord-010119-t1x9gknd 9910 9 necessary necessary JJ cord-010119-t1x9gknd 9910 10 to to TO cord-010119-t1x9gknd 9910 11 prevent prevent VB cord-010119-t1x9gknd 9910 12 transfusion transfusion NN cord-010119-t1x9gknd 9910 13 transmitted transmit VBN cord-010119-t1x9gknd 9910 14 HTLV HTLV NNP cord-010119-t1x9gknd 9910 15 infections infection NNS cord-010119-t1x9gknd 9910 16 ( ( -LRB- cord-010119-t1x9gknd 9910 17 anti anti JJ cord-010119-t1x9gknd 9910 18 - - JJ cord-010119-t1x9gknd 9910 19 HTLV htlv JJ cord-010119-t1x9gknd 9910 20 I I NNP cord-010119-t1x9gknd 9910 21 / / SYM cord-010119-t1x9gknd 9910 22 HTLV HTLV NNP cord-010119-t1x9gknd 9910 23 II II NNP cord-010119-t1x9gknd 9910 24 ) ) -RRB- cord-010119-t1x9gknd 9910 25 . . . cord-010119-t1x9gknd 9911 1 In in IN cord-010119-t1x9gknd 9911 2 non non JJ cord-010119-t1x9gknd 9911 3 - - JJ cord-010119-t1x9gknd 9911 4 endemic endemic JJ cord-010119-t1x9gknd 9911 5 countries country NNS cord-010119-t1x9gknd 9911 6 , , , cord-010119-t1x9gknd 9911 7 selective selective JJ cord-010119-t1x9gknd 9911 8 testing testing NN cord-010119-t1x9gknd 9911 9 may may MD cord-010119-t1x9gknd 9911 10 avoid avoid VB cord-010119-t1x9gknd 9911 11 unnecessary unnecessary JJ cord-010119-t1x9gknd 9911 12 temporal temporal JJ cord-010119-t1x9gknd 9911 13 deferrals deferral NNS cord-010119-t1x9gknd 9911 14 for for IN cord-010119-t1x9gknd 9911 15 donors donor NNS cord-010119-t1x9gknd 9911 16 at at IN cord-010119-t1x9gknd 9911 17 high high JJ cord-010119-t1x9gknd 9911 18 risk risk NN cord-010119-t1x9gknd 9911 19 , , , cord-010119-t1x9gknd 9911 20 such such JJ cord-010119-t1x9gknd 9911 21 as as IN cord-010119-t1x9gknd 9911 22 returning return VBG cord-010119-t1x9gknd 9911 23 travelers traveler NNS cord-010119-t1x9gknd 9911 24 from from IN cord-010119-t1x9gknd 9911 25 or or CC cord-010119-t1x9gknd 9911 26 donors donor NNS cord-010119-t1x9gknd 9911 27 born bear VBN cord-010119-t1x9gknd 9911 28 in in IN cord-010119-t1x9gknd 9911 29 countries country NNS cord-010119-t1x9gknd 9911 30 with with IN cord-010119-t1x9gknd 9911 31 a a DT cord-010119-t1x9gknd 9911 32 high high JJ cord-010119-t1x9gknd 9911 33 HTLV HTLV NNP cord-010119-t1x9gknd 9911 34 prevalence prevalence NN cord-010119-t1x9gknd 9911 35 . . . cord-010119-t1x9gknd 9912 1 Blood blood NN cord-010119-t1x9gknd 9912 2 centers center NNS cord-010119-t1x9gknd 9912 3 require require VBP cord-010119-t1x9gknd 9912 4 high high JJ cord-010119-t1x9gknd 9912 5 throughput throughput NN cord-010119-t1x9gknd 9912 6 anti anti JJ cord-010119-t1x9gknd 9912 7 - - JJ cord-010119-t1x9gknd 9912 8 HTLV htlv JJ cord-010119-t1x9gknd 9912 9 I I NNP cord-010119-t1x9gknd 9912 10 / / SYM cord-010119-t1x9gknd 9912 11 HTLV HTLV NNP cord-010119-t1x9gknd 9912 12 II II NNP cord-010119-t1x9gknd 9912 13 assays assay NNS cord-010119-t1x9gknd 9912 14 with with IN cord-010119-t1x9gknd 9912 15 high high JJ cord-010119-t1x9gknd 9912 16 specificity specificity NN cord-010119-t1x9gknd 9912 17 and and CC cord-010119-t1x9gknd 9912 18 sensitivity sensitivity NN cord-010119-t1x9gknd 9912 19 to to TO cord-010119-t1x9gknd 9912 20 prevent prevent VB cord-010119-t1x9gknd 9912 21 unnecessary unnecessary JJ cord-010119-t1x9gknd 9912 22 donor donor NN cord-010119-t1x9gknd 9912 23 deferrals deferral NNS cord-010119-t1x9gknd 9912 24 while while IN cord-010119-t1x9gknd 9912 25 maintaining maintain VBG cord-010119-t1x9gknd 9912 26 a a DT cord-010119-t1x9gknd 9912 27 safe safe JJ cord-010119-t1x9gknd 9912 28 blood blood NN cord-010119-t1x9gknd 9912 29 supply supply NN cord-010119-t1x9gknd 9912 30 . . . cord-010119-t1x9gknd 9913 1 In in IN cord-010119-t1x9gknd 9913 2 addition addition NN cord-010119-t1x9gknd 9913 3 , , , cord-010119-t1x9gknd 9913 4 continued continue VBN cord-010119-t1x9gknd 9913 5 pressures pressure NNS cord-010119-t1x9gknd 9913 6 on on IN cord-010119-t1x9gknd 9913 7 laboratory laboratory NN cord-010119-t1x9gknd 9913 8 operations operation NNS cord-010119-t1x9gknd 9913 9 demand demand VBP cord-010119-t1x9gknd 9913 10 that that IN cord-010119-t1x9gknd 9913 11 assays assay NNS cord-010119-t1x9gknd 9913 12 perform perform VBP cord-010119-t1x9gknd 9913 13 on on IN cord-010119-t1x9gknd 9913 14 platforms platform NNS cord-010119-t1x9gknd 9913 15 capable capable JJ cord-010119-t1x9gknd 9913 16 of of IN cord-010119-t1x9gknd 9913 17 increased increase VBN cord-010119-t1x9gknd 9913 18 walk walk NN cord-010119-t1x9gknd 9913 19 away away RB cord-010119-t1x9gknd 9913 20 time time NN cord-010119-t1x9gknd 9913 21 and and CC cord-010119-t1x9gknd 9913 22 enhanced enhanced JJ cord-010119-t1x9gknd 9913 23 automation automation NN cord-010119-t1x9gknd 9913 24 in in IN cord-010119-t1x9gknd 9913 25 areas area NNS cord-010119-t1x9gknd 9913 26 of of IN cord-010119-t1x9gknd 9913 27 reagent reagent NN cord-010119-t1x9gknd 9913 28 management management NN cord-010119-t1x9gknd 9913 29 , , , cord-010119-t1x9gknd 9913 30 retest retest VB cord-010119-t1x9gknd 9913 31 options option NNS cord-010119-t1x9gknd 9913 32 , , , cord-010119-t1x9gknd 9913 33 and and CC cord-010119-t1x9gknd 9913 34 commodity commodity NN cord-010119-t1x9gknd 9913 35 / / SYM cord-010119-t1x9gknd 9913 36 waste waste NN cord-010119-t1x9gknd 9913 37 management management NN cord-010119-t1x9gknd 9913 38 . . . cord-010119-t1x9gknd 9914 1 In in IN cord-010119-t1x9gknd 9914 2 response response NN cord-010119-t1x9gknd 9914 3 for for IN cord-010119-t1x9gknd 9914 4 the the DT cord-010119-t1x9gknd 9914 5 need need NN cord-010119-t1x9gknd 9914 6 of of IN cord-010119-t1x9gknd 9914 7 an an DT cord-010119-t1x9gknd 9914 8 assay assay NN cord-010119-t1x9gknd 9914 9 with with IN cord-010119-t1x9gknd 9914 10 high high JJ cord-010119-t1x9gknd 9914 11 specificity specificity NN cord-010119-t1x9gknd 9914 12 on on IN cord-010119-t1x9gknd 9914 13 a a DT cord-010119-t1x9gknd 9914 14 high high JJ cord-010119-t1x9gknd 9914 15 throughput throughput NN cord-010119-t1x9gknd 9914 16 instrument instrument NN cord-010119-t1x9gknd 9914 17 we -PRON- PRP cord-010119-t1x9gknd 9914 18 have have VBP cord-010119-t1x9gknd 9914 19 developed develop VBN cord-010119-t1x9gknd 9914 20 a a DT cord-010119-t1x9gknd 9914 21 new new JJ cord-010119-t1x9gknd 9914 22 assay assay NN cord-010119-t1x9gknd 9914 23 for for IN cord-010119-t1x9gknd 9914 24 the the DT cord-010119-t1x9gknd 9914 25 detection detection NN cord-010119-t1x9gknd 9914 26 of of IN cord-010119-t1x9gknd 9914 27 antibodies antibody NNS cord-010119-t1x9gknd 9914 28 against against IN cord-010119-t1x9gknd 9914 29 HTLV HTLV NNP cord-010119-t1x9gknd 9914 30 - - HYPH cord-010119-t1x9gknd 9914 31 I I NNP cord-010119-t1x9gknd 9914 32 / / SYM cord-010119-t1x9gknd 9914 33 II II NNP cord-010119-t1x9gknd 9914 34 antibodies antibody NNS cord-010119-t1x9gknd 9914 35 for for IN cord-010119-t1x9gknd 9914 36 the the DT cord-010119-t1x9gknd 9914 37 Alinity Alinity NNP cord-010119-t1x9gknd 9914 38 s s POS cord-010119-t1x9gknd 9914 39 System System NNP cord-010119-t1x9gknd 9914 40 . . . cord-010119-t1x9gknd 9915 1 Study Study NNP cord-010119-t1x9gknd 9915 2 Design Design NNP cord-010119-t1x9gknd 9915 3 / / SYM cord-010119-t1x9gknd 9915 4 Method method NN cord-010119-t1x9gknd 9915 5 : : : cord-010119-t1x9gknd 9916 1 Precision precision NN cord-010119-t1x9gknd 9916 2 was be VBD cord-010119-t1x9gknd 9916 3 assessed assess VBN cord-010119-t1x9gknd 9916 4 over over IN cord-010119-t1x9gknd 9916 5 20 20 CD cord-010119-t1x9gknd 9916 6 days day NNS cord-010119-t1x9gknd 9916 7 using use VBG cord-010119-t1x9gknd 9916 8 HTLV HTLV NNP cord-010119-t1x9gknd 9916 9 I I NNP cord-010119-t1x9gknd 9916 10 and and CC cord-010119-t1x9gknd 9916 11 HTLV HTLV NNP cord-010119-t1x9gknd 9916 12 II II NNP cord-010119-t1x9gknd 9916 13 positive positive JJ cord-010119-t1x9gknd 9916 14 samples sample NNS cord-010119-t1x9gknd 9916 15 . . . cord-010119-t1x9gknd 9917 1 Specificity specificity NN cord-010119-t1x9gknd 9917 2 was be VBD cord-010119-t1x9gknd 9917 3 evaluated evaluate VBN cord-010119-t1x9gknd 9917 4 using use VBG cord-010119-t1x9gknd 9917 5 8,001 8,001 CD cord-010119-t1x9gknd 9917 6 blood blood NN cord-010119-t1x9gknd 9917 7 donor donor NN cord-010119-t1x9gknd 9917 8 specimens specimen NNS cord-010119-t1x9gknd 9917 9 from from IN cord-010119-t1x9gknd 9917 10 Europe Europe NNP cord-010119-t1x9gknd 9917 11 and and CC cord-010119-t1x9gknd 9917 12 200 200 CD cord-010119-t1x9gknd 9917 13 diagnostic diagnostic JJ cord-010119-t1x9gknd 9917 14 samples sample NNS cord-010119-t1x9gknd 9917 15 obtained obtain VBN cord-010119-t1x9gknd 9917 16 from from IN cord-010119-t1x9gknd 9917 17 the the DT cord-010119-t1x9gknd 9917 18 United United NNP cord-010119-t1x9gknd 9917 19 States States NNP cord-010119-t1x9gknd 9917 20 . . . cord-010119-t1x9gknd 9918 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9918 2 was be VBD cord-010119-t1x9gknd 9918 3 evaluated evaluate VBN cord-010119-t1x9gknd 9918 4 using use VBG cord-010119-t1x9gknd 9918 5 500 500 CD cord-010119-t1x9gknd 9918 6 preselected preselecte VBN cord-010119-t1x9gknd 9918 7 HTLV HTLV NNP cord-010119-t1x9gknd 9918 8 I I NNP cord-010119-t1x9gknd 9918 9 and and CC cord-010119-t1x9gknd 9918 10 HTLV HTLV NNP cord-010119-t1x9gknd 9918 11 II II NNP cord-010119-t1x9gknd 9918 12 positive positive JJ cord-010119-t1x9gknd 9918 13 samples sample NNS cord-010119-t1x9gknd 9918 14 . . . cord-010119-t1x9gknd 9919 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9919 2 and and CC cord-010119-t1x9gknd 9919 3 specificity specificity NN cord-010119-t1x9gknd 9919 4 samples sample NNS cord-010119-t1x9gknd 9919 5 were be VBD cord-010119-t1x9gknd 9919 6 split split VBN cord-010119-t1x9gknd 9919 7 across across IN cord-010119-t1x9gknd 9919 8 3 3 CD cord-010119-t1x9gknd 9919 9 reagent reagent NN cord-010119-t1x9gknd 9919 10 lots lot NNS cord-010119-t1x9gknd 9919 11 during during IN cord-010119-t1x9gknd 9919 12 testing testing NN cord-010119-t1x9gknd 9919 13 . . . cord-010119-t1x9gknd 9920 1 Confirmation confirmation NN cord-010119-t1x9gknd 9920 2 of of IN cord-010119-t1x9gknd 9920 3 repeatedly repeatedly RB cord-010119-t1x9gknd 9920 4 reactive reactive JJ cord-010119-t1x9gknd 9920 5 samples sample NNS cord-010119-t1x9gknd 9920 6 was be VBD cord-010119-t1x9gknd 9920 7 done do VBN cord-010119-t1x9gknd 9920 8 using use VBG cord-010119-t1x9gknd 9920 9 the the DT cord-010119-t1x9gknd 9920 10 MP MP NNP cord-010119-t1x9gknd 9920 11 Diagnostic Diagnostic NNP cord-010119-t1x9gknd 9920 12 HTLV HTLV NNP cord-010119-t1x9gknd 9920 13 Blot Blot NNP cord-010119-t1x9gknd 9920 14 2.4 2.4 CD cord-010119-t1x9gknd 9920 15 . . . cord-010119-t1x9gknd 9921 1 Results/ Results/ . cord-010119-t1x9gknd 9922 1 Finding finding NN cord-010119-t1x9gknd 9922 2 : : : cord-010119-t1x9gknd 9923 1 Imprecision imprecision NN cord-010119-t1x9gknd 9923 2 was be VBD cord-010119-t1x9gknd 9923 3 less less JJR cord-010119-t1x9gknd 9923 4 than than IN cord-010119-t1x9gknd 9923 5 7.0 7.0 CD cord-010119-t1x9gknd 9923 6 % % NN cord-010119-t1x9gknd 9923 7 for for IN cord-010119-t1x9gknd 9923 8 positive positive JJ cord-010119-t1x9gknd 9923 9 samples sample NNS cord-010119-t1x9gknd 9923 10 over over IN cord-010119-t1x9gknd 9923 11 20 20 CD cord-010119-t1x9gknd 9923 12 days day NNS cord-010119-t1x9gknd 9923 13 . . . cord-010119-t1x9gknd 9924 1 Clinical clinical JJ cord-010119-t1x9gknd 9924 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9924 3 was be VBD cord-010119-t1x9gknd 9924 4 100.00 100.00 CD cord-010119-t1x9gknd 9924 5 % % NN cord-010119-t1x9gknd 9924 6 ( ( -LRB- cord-010119-t1x9gknd 9924 7 500/500 500/500 NNP cord-010119-t1x9gknd 9924 8 ) ) -RRB- cord-010119-t1x9gknd 9924 9 on on IN cord-010119-t1x9gknd 9924 10 preselected preselecte VBN cord-010119-t1x9gknd 9924 11 HTLV HTLV NNP cord-010119-t1x9gknd 9924 12 I I NNP cord-010119-t1x9gknd 9924 13 and and CC cord-010119-t1x9gknd 9924 14 HTLV HTLV NNP cord-010119-t1x9gknd 9924 15 II II NNP cord-010119-t1x9gknd 9924 16 positive positive JJ cord-010119-t1x9gknd 9924 17 samples sample NNS cord-010119-t1x9gknd 9924 18 . . . cord-010119-t1x9gknd 9925 1 The the DT cord-010119-t1x9gknd 9925 2 specificity specificity NN cord-010119-t1x9gknd 9925 3 was be VBD cord-010119-t1x9gknd 9925 4 99.98 99.98 CD cord-010119-t1x9gknd 9925 5 % % NN cord-010119-t1x9gknd 9925 6 ( ( -LRB- cord-010119-t1x9gknd 9925 7 7,999/8,001 7,999/8,001 CD cord-010119-t1x9gknd 9925 8 ) ) -RRB- cord-010119-t1x9gknd 9925 9 on on IN cord-010119-t1x9gknd 9925 10 a a DT cord-010119-t1x9gknd 9925 11 blood blood NN cord-010119-t1x9gknd 9925 12 donor donor NN cord-010119-t1x9gknd 9925 13 population population NN cord-010119-t1x9gknd 9925 14 and and CC cord-010119-t1x9gknd 9925 15 100.00 100.00 CD cord-010119-t1x9gknd 9925 16 % % NN cord-010119-t1x9gknd 9925 17 ( ( -LRB- cord-010119-t1x9gknd 9925 18 200/200 200/200 NNP cord-010119-t1x9gknd 9925 19 ) ) -RRB- cord-010119-t1x9gknd 9925 20 on on IN cord-010119-t1x9gknd 9925 21 diagnostic diagnostic JJ cord-010119-t1x9gknd 9925 22 samples sample NNS cord-010119-t1x9gknd 9925 23 . . . cord-010119-t1x9gknd 9926 1 Conclusion conclusion NN cord-010119-t1x9gknd 9926 2 : : : cord-010119-t1x9gknd 9927 1 These these DT cord-010119-t1x9gknd 9927 2 results result NNS cord-010119-t1x9gknd 9927 3 indicate indicate VBP cord-010119-t1x9gknd 9927 4 that that IN cord-010119-t1x9gknd 9927 5 the the DT cord-010119-t1x9gknd 9927 6 new new JJ cord-010119-t1x9gknd 9927 7 Alinity Alinity NNP cord-010119-t1x9gknd 9927 8 s s POS cord-010119-t1x9gknd 9927 9 automated automate VBD cord-010119-t1x9gknd 9927 10 HTLV HTLV NNP cord-010119-t1x9gknd 9927 11 I/ I/ NNP cord-010119-t1x9gknd 9927 12 II II NNP cord-010119-t1x9gknd 9927 13 assay assay NN cord-010119-t1x9gknd 9927 14 provided provide VBD cord-010119-t1x9gknd 9927 15 very very RB cord-010119-t1x9gknd 9927 16 good good JJ cord-010119-t1x9gknd 9927 17 performance performance NN cord-010119-t1x9gknd 9927 18 in in IN cord-010119-t1x9gknd 9927 19 specificity specificity NN cord-010119-t1x9gknd 9927 20 , , , cord-010119-t1x9gknd 9927 21 sensitivity sensitivity NN cord-010119-t1x9gknd 9927 22 , , , cord-010119-t1x9gknd 9927 23 and and CC cord-010119-t1x9gknd 9927 24 precision precision NN cord-010119-t1x9gknd 9927 25 . . . cord-010119-t1x9gknd 9928 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9928 2 and and CC cord-010119-t1x9gknd 9928 3 specificity specificity NN cord-010119-t1x9gknd 9928 4 were be VBD cord-010119-t1x9gknd 9928 5 comparable comparable JJ cord-010119-t1x9gknd 9928 6 to to IN cord-010119-t1x9gknd 9928 7 the the DT cord-010119-t1x9gknd 9928 8 comparator comparator NN cord-010119-t1x9gknd 9928 9 assay assay NN cord-010119-t1x9gknd 9928 10 . . . cord-010119-t1x9gknd 9929 1 Claudia Claudia NNP cord-010119-t1x9gknd 9929 2 Ramirez Ramirez NNP cord-010119-t1x9gknd 9929 3 1 1 CD cord-010119-t1x9gknd 9929 4 , , , cord-010119-t1x9gknd 9929 5 Michel Michel NNP cord-010119-t1x9gknd 9929 6 Garcia Garcia NNP cord-010119-t1x9gknd 9929 7 * * NFP cord-010119-t1x9gknd 9929 8 2 2 CD cord-010119-t1x9gknd 9929 9 , , , cord-010119-t1x9gknd 9929 10 Fernando Fernando NNP cord-010119-t1x9gknd 9929 11 Palomino Palomino NNP cord-010119-t1x9gknd 9929 12 3 3 CD cord-010119-t1x9gknd 9929 13 and and CC cord-010119-t1x9gknd 9929 14 Guillermo Guillermo NNP cord-010119-t1x9gknd 9929 15 Orjuela Orjuela NNP cord-010119-t1x9gknd 9929 16 - - HYPH cord-010119-t1x9gknd 9929 17 Falla Falla NNP cord-010119-t1x9gknd 9929 18 1 1 CD cord-010119-t1x9gknd 9929 19 . . . cord-010119-t1x9gknd 9930 1 1 1 LS cord-010119-t1x9gknd 9930 2 National National NNP cord-010119-t1x9gknd 9930 3 Blood Blood NNP cord-010119-t1x9gknd 9930 4 Bank Bank NNP cord-010119-t1x9gknd 9930 5 Colombian Colombian NNP cord-010119-t1x9gknd 9930 6 Red Red NNP cord-010119-t1x9gknd 9930 7 Cross Cross NNP cord-010119-t1x9gknd 9930 8 , , , cord-010119-t1x9gknd 9930 9 2 2 CD cord-010119-t1x9gknd 9930 10 Universidad Universidad NNP cord-010119-t1x9gknd 9930 11 Del Del NNP cord-010119-t1x9gknd 9930 12 Rosario Rosario NNP cord-010119-t1x9gknd 9930 13 , , , cord-010119-t1x9gknd 9930 14 3 3 CD cord-010119-t1x9gknd 9930 15 FUATS FUATS NNP cord-010119-t1x9gknd 9930 16 Background Background NNP cord-010119-t1x9gknd 9930 17 / / SYM cord-010119-t1x9gknd 9930 18 Case Case NNP cord-010119-t1x9gknd 9930 19 Studies Studies NNPS cord-010119-t1x9gknd 9930 20 : : : cord-010119-t1x9gknd 9930 21 Current current JJ cord-010119-t1x9gknd 9930 22 hepatitis hepatitis NN cord-010119-t1x9gknd 9930 23 C c NN cord-010119-t1x9gknd 9930 24 virus virus NN cord-010119-t1x9gknd 9930 25 ( ( -LRB- cord-010119-t1x9gknd 9930 26 HCV HCV NNP cord-010119-t1x9gknd 9930 27 ) ) -RRB- cord-010119-t1x9gknd 9930 28 supplemental supplemental JJ cord-010119-t1x9gknd 9930 29 testing testing NN cord-010119-t1x9gknd 9930 30 algorithm algorithm NN cord-010119-t1x9gknd 9930 31 for for IN cord-010119-t1x9gknd 9930 32 blood blood NN cord-010119-t1x9gknd 9930 33 donations donation NNS cord-010119-t1x9gknd 9930 34 in in IN cord-010119-t1x9gknd 9930 35 Colombia Colombia NNP cord-010119-t1x9gknd 9930 36 , , , cord-010119-t1x9gknd 9930 37 requires require VBZ cord-010119-t1x9gknd 9930 38 that that IN cord-010119-t1x9gknd 9930 39 an an DT cord-010119-t1x9gknd 9930 40 immunoblot immunoblot NNP cord-010119-t1x9gknd 9930 41 assay assay NN cord-010119-t1x9gknd 9930 42 be be VB cord-010119-t1x9gknd 9930 43 performed perform VBN cord-010119-t1x9gknd 9930 44 on on IN cord-010119-t1x9gknd 9930 45 every every DT cord-010119-t1x9gknd 9930 46 HCV HCV NNP cord-010119-t1x9gknd 9930 47 enzyme enzyme NN cord-010119-t1x9gknd 9930 48 immunoassay immunoassay NN cord-010119-t1x9gknd 9930 49 ( ( -LRB- cord-010119-t1x9gknd 9930 50 EIA EIA NNP cord-010119-t1x9gknd 9930 51 ) ) -RRB- cord-010119-t1x9gknd 9930 52 repeatreactive repeatreactive JJ cord-010119-t1x9gknd 9930 53 sample sample NN cord-010119-t1x9gknd 9930 54 . . . cord-010119-t1x9gknd 9931 1 A a DT cord-010119-t1x9gknd 9931 2 higher high JJR cord-010119-t1x9gknd 9931 3 proportion proportion NN cord-010119-t1x9gknd 9931 4 of of IN cord-010119-t1x9gknd 9931 5 indeterminate indeterminate JJ cord-010119-t1x9gknd 9931 6 ( ( -LRB- cord-010119-t1x9gknd 9931 7 IND IND NNP cord-010119-t1x9gknd 9931 8 ) ) -RRB- cord-010119-t1x9gknd 9931 9 results result VBZ cord-010119-t1x9gknd 9931 10 by by IN cord-010119-t1x9gknd 9931 11 immunoblot immunoblot NNP cord-010119-t1x9gknd 9931 12 assays assay NNS cord-010119-t1x9gknd 9931 13 has have VBZ cord-010119-t1x9gknd 9931 14 been be VBN cord-010119-t1x9gknd 9931 15 documented document VBN cord-010119-t1x9gknd 9931 16 for for IN cord-010119-t1x9gknd 9931 17 non non JJ cord-010119-t1x9gknd 9931 18 - - JJ cord-010119-t1x9gknd 9931 19 US US NNP cord-010119-t1x9gknd 9931 20 donor donor NN cord-010119-t1x9gknd 9931 21 samples sample NNS cord-010119-t1x9gknd 9931 22 , , , cord-010119-t1x9gknd 9931 23 affecting affect VBG cord-010119-t1x9gknd 9931 24 donor donor NN cord-010119-t1x9gknd 9931 25 counseling counseling NN cord-010119-t1x9gknd 9931 26 and and CC cord-010119-t1x9gknd 9931 27 eventually eventually RB cord-010119-t1x9gknd 9931 28 increasing increase VBG cord-010119-t1x9gknd 9931 29 costs cost NNS cord-010119-t1x9gknd 9931 30 and and CC cord-010119-t1x9gknd 9931 31 opportunity opportunity NN cord-010119-t1x9gknd 9931 32 for for IN cord-010119-t1x9gknd 9931 33 the the DT cord-010119-t1x9gknd 9931 34 notification notification NN cord-010119-t1x9gknd 9931 35 of of IN cord-010119-t1x9gknd 9931 36 infected infected JJ cord-010119-t1x9gknd 9931 37 donors donor NNS cord-010119-t1x9gknd 9931 38 . . . cord-010119-t1x9gknd 9932 1 This this DT cord-010119-t1x9gknd 9932 2 work work NN cord-010119-t1x9gknd 9932 3 aimed aim VBN cord-010119-t1x9gknd 9932 4 to to TO cord-010119-t1x9gknd 9932 5 establish establish VB cord-010119-t1x9gknd 9932 6 the the DT cord-010119-t1x9gknd 9932 7 distribution distribution NN cord-010119-t1x9gknd 9932 8 of of IN cord-010119-t1x9gknd 9932 9 immunoblot immunoblot NN cord-010119-t1x9gknd 9932 10 results result NNS cord-010119-t1x9gknd 9932 11 in in IN cord-010119-t1x9gknd 9932 12 Colombian colombian JJ cord-010119-t1x9gknd 9932 13 repeat repeat NN cord-010119-t1x9gknd 9932 14 - - HYPH cord-010119-t1x9gknd 9932 15 reactive reactive JJ cord-010119-t1x9gknd 9932 16 samples sample NNS cord-010119-t1x9gknd 9932 17 , , , cord-010119-t1x9gknd 9932 18 as as RB cord-010119-t1x9gknd 9932 19 well well RB cord-010119-t1x9gknd 9932 20 as as IN cord-010119-t1x9gknd 9932 21 the the DT cord-010119-t1x9gknd 9932 22 frequency frequency NN cord-010119-t1x9gknd 9932 23 of of IN cord-010119-t1x9gknd 9932 24 band band NN cord-010119-t1x9gknd 9932 25 detection detection NN cord-010119-t1x9gknd 9932 26 in in IN cord-010119-t1x9gknd 9932 27 both both DT cord-010119-t1x9gknd 9932 28 positive positive JJ cord-010119-t1x9gknd 9932 29 and and CC cord-010119-t1x9gknd 9932 30 indeterminate indeterminate JJ cord-010119-t1x9gknd 9932 31 blots blot NNS cord-010119-t1x9gknd 9932 32 . . . cord-010119-t1x9gknd 9933 1 Study Study NNP cord-010119-t1x9gknd 9933 2 Design Design NNP cord-010119-t1x9gknd 9933 3 / / SYM cord-010119-t1x9gknd 9933 4 Method method NN cord-010119-t1x9gknd 9933 5 : : : cord-010119-t1x9gknd 9934 1 In in IN cord-010119-t1x9gknd 9934 2 total total NN cord-010119-t1x9gknd 9934 3 , , , cord-010119-t1x9gknd 9934 4 387 387 CD cord-010119-t1x9gknd 9934 5 anti anti JJ cord-010119-t1x9gknd 9934 6 - - JJ cord-010119-t1x9gknd 9934 7 HCV hcv JJ cord-010119-t1x9gknd 9934 8 - - HYPH cord-010119-t1x9gknd 9934 9 reactive reactive JJ cord-010119-t1x9gknd 9934 10 donor donor NN cord-010119-t1x9gknd 9934 11 samples sample NNS cord-010119-t1x9gknd 9934 12 ( ( -LRB- cord-010119-t1x9gknd 9934 13 signal signal NN cord-010119-t1x9gknd 9934 14 - - HYPH cord-010119-t1x9gknd 9934 15 to to IN cord-010119-t1x9gknd 9934 16 - - HYPH cord-010119-t1x9gknd 9934 17 cutoff cutoff NN cord-010119-t1x9gknd 9934 18 ( ( -LRB- cord-010119-t1x9gknd 9934 19 S S NNP cord-010119-t1x9gknd 9934 20 / / SYM cord-010119-t1x9gknd 9934 21 CO co NN cord-010119-t1x9gknd 9934 22 ) ) -RRB- cord-010119-t1x9gknd 9934 23 ratio ratio NN cord-010119-t1x9gknd 9934 24 greater great JJR cord-010119-t1x9gknd 9934 25 than than IN cord-010119-t1x9gknd 9934 26 1.0 1.0 CD cord-010119-t1x9gknd 9934 27 ; ; : cord-010119-t1x9gknd 9934 28 Abbott Abbott NNP cord-010119-t1x9gknd 9934 29 Architect Architect NNP cord-010119-t1x9gknd 9934 30 i2000SR i2000SR NNP cord-010119-t1x9gknd 9934 31 ) ) -RRB- cord-010119-t1x9gknd 9934 32 underwent undergo VBD cord-010119-t1x9gknd 9934 33 supplemental supplemental JJ cord-010119-t1x9gknd 9934 34 testing testing NN cord-010119-t1x9gknd 9934 35 by by IN cord-010119-t1x9gknd 9934 36 immunoblot immunoblot NNP cord-010119-t1x9gknd 9934 37 ( ( -LRB- cord-010119-t1x9gknd 9934 38 either either CC cord-010119-t1x9gknd 9934 39 Chiron Chiron NNP cord-010119-t1x9gknd 9934 40 RIBA RIBA NNP cord-010119-t1x9gknd 9934 41 HCV HCV NNP cord-010119-t1x9gknd 9934 42 3.0 3.0 NNP cord-010119-t1x9gknd 9934 43 SIA SIA NNP cord-010119-t1x9gknd 9934 44 or or CC cord-010119-t1x9gknd 9934 45 HCV HCV NNP cord-010119-t1x9gknd 9934 46 Blot Blot NNP cord-010119-t1x9gknd 9934 47 3.0 3.0 CD cord-010119-t1x9gknd 9934 48 test test NN cord-010119-t1x9gknd 9934 49 , , , cord-010119-t1x9gknd 9934 50 MP MP NNP cord-010119-t1x9gknd 9934 51 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9934 52 ) ) -RRB- cord-010119-t1x9gknd 9934 53 . . . cord-010119-t1x9gknd 9935 1 Negative negative JJ cord-010119-t1x9gknd 9935 2 ( ( -LRB- cord-010119-t1x9gknd 9935 3 NEG NEG NNP cord-010119-t1x9gknd 9935 4 ) ) -RRB- cord-010119-t1x9gknd 9935 5 , , , cord-010119-t1x9gknd 9935 6 indeterminate indeterminate JJ cord-010119-t1x9gknd 9935 7 ( ( -LRB- cord-010119-t1x9gknd 9935 8 IND IND NNP cord-010119-t1x9gknd 9935 9 ) ) -RRB- cord-010119-t1x9gknd 9935 10 and and CC cord-010119-t1x9gknd 9935 11 positive positive JJ cord-010119-t1x9gknd 9935 12 ( ( -LRB- cord-010119-t1x9gknd 9935 13 POS POS NNP cord-010119-t1x9gknd 9935 14 ) ) -RRB- cord-010119-t1x9gknd 9935 15 blot blot NN cord-010119-t1x9gknd 9935 16 results result NNS cord-010119-t1x9gknd 9935 17 were be VBD cord-010119-t1x9gknd 9935 18 grouped group VBN cord-010119-t1x9gknd 9935 19 by by IN cord-010119-t1x9gknd 9935 20 S S NNP cord-010119-t1x9gknd 9935 21 / / SYM cord-010119-t1x9gknd 9935 22 CO CO NNP cord-010119-t1x9gknd 9935 23 ranges range VBZ cord-010119-t1x9gknd 9935 24 as as IN cord-010119-t1x9gknd 9935 25 follows follow VBZ cord-010119-t1x9gknd 9935 26 : : : cord-010119-t1x9gknd 9935 27 1 1 CD cord-010119-t1x9gknd 9935 28 - - SYM cord-010119-t1x9gknd 9935 29 4.99 4.99 CD cord-010119-t1x9gknd 9935 30 , , , cord-010119-t1x9gknd 9935 31 5 5 CD cord-010119-t1x9gknd 9935 32 - - SYM cord-010119-t1x9gknd 9935 33 9.99 9.99 CD cord-010119-t1x9gknd 9935 34 , , , cord-010119-t1x9gknd 9935 35 > > XX cord-010119-t1x9gknd 9935 36 10 10 CD cord-010119-t1x9gknd 9935 37 . . . cord-010119-t1x9gknd 9936 1 Band band NN cord-010119-t1x9gknd 9936 2 detection detection NN cord-010119-t1x9gknd 9936 3 and and CC cord-010119-t1x9gknd 9936 4 intensity intensity NN cord-010119-t1x9gknd 9936 5 were be VBD cord-010119-t1x9gknd 9936 6 independently independently RB cord-010119-t1x9gknd 9936 7 analyzed analyze VBN cord-010119-t1x9gknd 9936 8 for for IN cord-010119-t1x9gknd 9936 9 indeterminate indeterminate JJ cord-010119-t1x9gknd 9936 10 and and CC cord-010119-t1x9gknd 9936 11 positive positive JJ cord-010119-t1x9gknd 9936 12 results result NNS cord-010119-t1x9gknd 9936 13 . . . cord-010119-t1x9gknd 9937 1 Results/ Results/ . cord-010119-t1x9gknd 9938 1 Finding finding NN cord-010119-t1x9gknd 9938 2 : : : cord-010119-t1x9gknd 9939 1 Immunoblot immunoblot NN cord-010119-t1x9gknd 9939 2 results result NNS cord-010119-t1x9gknd 9939 3 were be VBD cord-010119-t1x9gknd 9939 4 negative negative JJ cord-010119-t1x9gknd 9939 5 in in IN cord-010119-t1x9gknd 9939 6 57.9 57.9 CD cord-010119-t1x9gknd 9939 7 % % NN cord-010119-t1x9gknd 9939 8 ( ( -LRB- cord-010119-t1x9gknd 9939 9 224/387 224/387 NNP cord-010119-t1x9gknd 9939 10 ) ) -RRB- cord-010119-t1x9gknd 9939 11 of of IN cord-010119-t1x9gknd 9939 12 samples sample NNS cord-010119-t1x9gknd 9939 13 , , , cord-010119-t1x9gknd 9939 14 indeterminate indeterminate JJ cord-010119-t1x9gknd 9939 15 in in IN cord-010119-t1x9gknd 9939 16 30.7 30.7 CD cord-010119-t1x9gknd 9939 17 % % NN cord-010119-t1x9gknd 9939 18 ( ( -LRB- cord-010119-t1x9gknd 9939 19 119/387 119/387 CD cord-010119-t1x9gknd 9939 20 ) ) -RRB- cord-010119-t1x9gknd 9939 21 and and CC cord-010119-t1x9gknd 9939 22 were be VBD cord-010119-t1x9gknd 9939 23 positive positive JJ cord-010119-t1x9gknd 9939 24 in in IN cord-010119-t1x9gknd 9939 25 11.4 11.4 CD cord-010119-t1x9gknd 9939 26 % % NN cord-010119-t1x9gknd 9939 27 ( ( -LRB- cord-010119-t1x9gknd 9939 28 44/ 44/ CD cord-010119-t1x9gknd 9939 29 387 387 CD cord-010119-t1x9gknd 9939 30 ) ) -RRB- cord-010119-t1x9gknd 9939 31 . . . cord-010119-t1x9gknd 9940 1 A a DT cord-010119-t1x9gknd 9940 2 direct direct JJ cord-010119-t1x9gknd 9940 3 relationship relationship NN cord-010119-t1x9gknd 9940 4 was be VBD cord-010119-t1x9gknd 9940 5 observed observe VBN cord-010119-t1x9gknd 9940 6 between between IN cord-010119-t1x9gknd 9940 7 positive positive JJ cord-010119-t1x9gknd 9940 8 immunoblot immunoblot NNS cord-010119-t1x9gknd 9940 9 and and CC cord-010119-t1x9gknd 9940 10 increased increase VBN cord-010119-t1x9gknd 9940 11 S S NNP cord-010119-t1x9gknd 9940 12 / / SYM cord-010119-t1x9gknd 9940 13 CO CO NNP cord-010119-t1x9gknd 9940 14 . . . cord-010119-t1x9gknd 9941 1 The the DT cord-010119-t1x9gknd 9941 2 proportion proportion NN cord-010119-t1x9gknd 9941 3 of of IN cord-010119-t1x9gknd 9941 4 IND IND NNP cord-010119-t1x9gknd 9941 5 results result NNS cord-010119-t1x9gknd 9941 6 were be VBD cord-010119-t1x9gknd 9941 7 higher high JJR cord-010119-t1x9gknd 9941 8 in in IN cord-010119-t1x9gknd 9941 9 the the DT cord-010119-t1x9gknd 9941 10 S S NNP cord-010119-t1x9gknd 9941 11 / / SYM cord-010119-t1x9gknd 9941 12 CO CO NNP cord-010119-t1x9gknd 9941 13 group group NN cord-010119-t1x9gknd 9941 14 5 5 CD cord-010119-t1x9gknd 9941 15 - - SYM cord-010119-t1x9gknd 9941 16 9.99 9.99 CD cord-010119-t1x9gknd 9941 17 ( ( -LRB- cord-010119-t1x9gknd 9941 18 63.2 63.2 CD cord-010119-t1x9gknd 9941 19 % % NN cord-010119-t1x9gknd 9941 20 ) ) -RRB- cord-010119-t1x9gknd 9941 21 compared compare VBN cord-010119-t1x9gknd 9941 22 with with IN cord-010119-t1x9gknd 9941 23 the the DT cord-010119-t1x9gknd 9941 24 1 1 CD cord-010119-t1x9gknd 9941 25 - - SYM cord-010119-t1x9gknd 9941 26 4.99 4.99 CD cord-010119-t1x9gknd 9941 27 ( ( -LRB- cord-010119-t1x9gknd 9941 28 29.9 29.9 CD cord-010119-t1x9gknd 9941 29 % % NN cord-010119-t1x9gknd 9941 30 ) ) -RRB- cord-010119-t1x9gknd 9941 31 . . . cord-010119-t1x9gknd 9942 1 In in IN cord-010119-t1x9gknd 9942 2 samples sample NNS cord-010119-t1x9gknd 9942 3 with with IN cord-010119-t1x9gknd 9942 4 indeterminate indeterminate JJ cord-010119-t1x9gknd 9942 5 results result NNS cord-010119-t1x9gknd 9942 6 , , , cord-010119-t1x9gknd 9942 7 NS3_2 NS3_2 NNP cord-010119-t1x9gknd 9942 8 was be VBD cord-010119-t1x9gknd 9942 9 the the DT cord-010119-t1x9gknd 9942 10 most most RBS cord-010119-t1x9gknd 9942 11 frequent frequent JJ cord-010119-t1x9gknd 9942 12 band band NN cord-010119-t1x9gknd 9942 13 detected detect VBD cord-010119-t1x9gknd 9942 14 ( ( -LRB- cord-010119-t1x9gknd 9942 15 52,9 52,9 CD cord-010119-t1x9gknd 9942 16 % % NN cord-010119-t1x9gknd 9942 17 ) ) -RRB- cord-010119-t1x9gknd 9942 18 . . . cord-010119-t1x9gknd 9943 1 In in IN cord-010119-t1x9gknd 9943 2 contrast contrast NN cord-010119-t1x9gknd 9943 3 , , , cord-010119-t1x9gknd 9943 4 the the DT cord-010119-t1x9gknd 9943 5 most most RBS cord-010119-t1x9gknd 9943 6 frequent frequent JJ cord-010119-t1x9gknd 9943 7 band band NN cord-010119-t1x9gknd 9943 8 in in IN cord-010119-t1x9gknd 9943 9 the the DT cord-010119-t1x9gknd 9943 10 group group NN cord-010119-t1x9gknd 9943 11 of of IN cord-010119-t1x9gknd 9943 12 positive positive JJ cord-010119-t1x9gknd 9943 13 results result NNS cord-010119-t1x9gknd 9943 14 was be VBD cord-010119-t1x9gknd 9943 15 CORE core NN cord-010119-t1x9gknd 9943 16 ( ( -LRB- cord-010119-t1x9gknd 9943 17 93,2 93,2 CD cord-010119-t1x9gknd 9943 18 % % NN cord-010119-t1x9gknd 9943 19 ) ) -RRB- cord-010119-t1x9gknd 9943 20 . . . cord-010119-t1x9gknd 9944 1 Only only RB cord-010119-t1x9gknd 9944 2 one one CD cord-010119-t1x9gknd 9944 3 sample sample NN cord-010119-t1x9gknd 9944 4 from from IN cord-010119-t1x9gknd 9944 5 the the DT cord-010119-t1x9gknd 9944 6 indeterminate indeterminate JJ cord-010119-t1x9gknd 9944 7 group group NN cord-010119-t1x9gknd 9944 8 ( ( -LRB- cord-010119-t1x9gknd 9944 9 0.8 0.8 CD cord-010119-t1x9gknd 9944 10 % % NN cord-010119-t1x9gknd 9944 11 ) ) -RRB- cord-010119-t1x9gknd 9944 12 had have VBD cord-010119-t1x9gknd 9944 13 a a DT cord-010119-t1x9gknd 9944 14 strong strong JJ cord-010119-t1x9gknd 9944 15 band band NN cord-010119-t1x9gknd 9944 16 intensity intensity NN cord-010119-t1x9gknd 9944 17 ( ( -LRB- cord-010119-t1x9gknd 9944 18 31 31 CD cord-010119-t1x9gknd 9944 19 ) ) -RRB- cord-010119-t1x9gknd 9944 20 , , , cord-010119-t1x9gknd 9944 21 compared compare VBN cord-010119-t1x9gknd 9944 22 with with IN cord-010119-t1x9gknd 9944 23 10 10 CD cord-010119-t1x9gknd 9944 24 samples sample NNS cord-010119-t1x9gknd 9944 25 from from IN cord-010119-t1x9gknd 9944 26 the the DT cord-010119-t1x9gknd 9944 27 positive positive JJ cord-010119-t1x9gknd 9944 28 group group NN cord-010119-t1x9gknd 9944 29 ( ( -LRB- cord-010119-t1x9gknd 9944 30 22.7 22.7 CD cord-010119-t1x9gknd 9944 31 % % NN cord-010119-t1x9gknd 9944 32 ) ) -RRB- cord-010119-t1x9gknd 9944 33 . . . cord-010119-t1x9gknd 9945 1 Conclusion conclusion NN cord-010119-t1x9gknd 9945 2 : : : cord-010119-t1x9gknd 9946 1 The the DT cord-010119-t1x9gknd 9946 2 proportion proportion NN cord-010119-t1x9gknd 9946 3 of of IN cord-010119-t1x9gknd 9946 4 indeterminate indeterminate JJ cord-010119-t1x9gknd 9946 5 immunoblot immunoblot NN cord-010119-t1x9gknd 9946 6 results result NNS cord-010119-t1x9gknd 9946 7 in in IN cord-010119-t1x9gknd 9946 8 this this DT cord-010119-t1x9gknd 9946 9 sample sample NN cord-010119-t1x9gknd 9946 10 of of IN cord-010119-t1x9gknd 9946 11 Colombian colombian JJ cord-010119-t1x9gknd 9946 12 donors donor NNS cord-010119-t1x9gknd 9946 13 is be VBZ cord-010119-t1x9gknd 9946 14 one one CD cord-010119-t1x9gknd 9946 15 of of IN cord-010119-t1x9gknd 9946 16 the the DT cord-010119-t1x9gknd 9946 17 highest high JJS cord-010119-t1x9gknd 9946 18 ever ever RB cord-010119-t1x9gknd 9946 19 reported report VBN cord-010119-t1x9gknd 9946 20 , , , cord-010119-t1x9gknd 9946 21 being be VBG cord-010119-t1x9gknd 9946 22 twice twice RB cord-010119-t1x9gknd 9946 23 as as RB cord-010119-t1x9gknd 9946 24 much much JJ cord-010119-t1x9gknd 9946 25 as as IN cord-010119-t1x9gknd 9946 26 the the DT cord-010119-t1x9gknd 9946 27 proportion proportion NN cord-010119-t1x9gknd 9946 28 found find VBN cord-010119-t1x9gknd 9946 29 in in IN cord-010119-t1x9gknd 9946 30 larger large JJR cord-010119-t1x9gknd 9946 31 samples sample NNS cord-010119-t1x9gknd 9946 32 of of IN cord-010119-t1x9gknd 9946 33 US US NNP cord-010119-t1x9gknd 9946 34 donors donor NNS cord-010119-t1x9gknd 9946 35 . . . cord-010119-t1x9gknd 9947 1 The the DT cord-010119-t1x9gknd 9947 2 high high JJ cord-010119-t1x9gknd 9947 3 proportion proportion NN cord-010119-t1x9gknd 9947 4 of of IN cord-010119-t1x9gknd 9947 5 IND IND NNP cord-010119-t1x9gknd 9947 6 results result NNS cord-010119-t1x9gknd 9947 7 found find VBN cord-010119-t1x9gknd 9947 8 in in IN cord-010119-t1x9gknd 9947 9 the the DT cord-010119-t1x9gknd 9947 10 S S NNP cord-010119-t1x9gknd 9947 11 / / SYM cord-010119-t1x9gknd 9947 12 CO CO NNP cord-010119-t1x9gknd 9947 13 group group NN cord-010119-t1x9gknd 9947 14 ( ( -LRB- cord-010119-t1x9gknd 9947 15 5 5 CD cord-010119-t1x9gknd 9947 16 - - SYM cord-010119-t1x9gknd 9947 17 9.99 9.99 CD cord-010119-t1x9gknd 9947 18 ) ) -RRB- cord-010119-t1x9gknd 9947 19 suggests suggest VBZ cord-010119-t1x9gknd 9947 20 that that IN cord-010119-t1x9gknd 9947 21 the the DT cord-010119-t1x9gknd 9947 22 optimal optimal JJ cord-010119-t1x9gknd 9947 23 S S NNP cord-010119-t1x9gknd 9947 24 / / SYM cord-010119-t1x9gknd 9947 25 CO co NN cord-010119-t1x9gknd 9947 26 ratio ratio NN cord-010119-t1x9gknd 9947 27 for for IN cord-010119-t1x9gknd 9947 28 predicting predict VBG cord-010119-t1x9gknd 9947 29 a a DT cord-010119-t1x9gknd 9947 30 confirmed confirm VBN cord-010119-t1x9gknd 9947 31 anti anti JJ cord-010119-t1x9gknd 9947 32 - - JJ cord-010119-t1x9gknd 9947 33 HCV HCV NNP cord-010119-t1x9gknd 9947 34 result result NN cord-010119-t1x9gknd 9947 35 in in IN cord-010119-t1x9gknd 9947 36 this this DT cord-010119-t1x9gknd 9947 37 population population NN cord-010119-t1x9gknd 9947 38 should should MD cord-010119-t1x9gknd 9947 39 be be VB cord-010119-t1x9gknd 9947 40 higher high JJR cord-010119-t1x9gknd 9947 41 than than IN cord-010119-t1x9gknd 9947 42 the the DT cord-010119-t1x9gknd 9947 43 one one NN cord-010119-t1x9gknd 9947 44 recommended recommend VBN cord-010119-t1x9gknd 9947 45 by by IN cord-010119-t1x9gknd 9947 46 the the DT cord-010119-t1x9gknd 9947 47 CDC CDC NNP cord-010119-t1x9gknd 9947 48 for for IN cord-010119-t1x9gknd 9947 49 US US NNP cord-010119-t1x9gknd 9947 50 population population NN cord-010119-t1x9gknd 9947 51 ( ( -LRB- cord-010119-t1x9gknd 9947 52 > > NFP cord-010119-t1x9gknd 9947 53 5 5 CD cord-010119-t1x9gknd 9947 54 ) ) -RRB- cord-010119-t1x9gknd 9947 55 . . . cord-010119-t1x9gknd 9948 1 Overall overall RB cord-010119-t1x9gknd 9948 2 , , , cord-010119-t1x9gknd 9948 3 these these DT cord-010119-t1x9gknd 9948 4 results result NNS cord-010119-t1x9gknd 9948 5 suggest suggest VBP cord-010119-t1x9gknd 9948 6 that that IN cord-010119-t1x9gknd 9948 7 the the DT cord-010119-t1x9gknd 9948 8 supplemental supplemental JJ cord-010119-t1x9gknd 9948 9 testing testing NN cord-010119-t1x9gknd 9948 10 algorithm algorithm NN cord-010119-t1x9gknd 9948 11 for for IN cord-010119-t1x9gknd 9948 12 blood blood NN cord-010119-t1x9gknd 9948 13 donations donation NNS cord-010119-t1x9gknd 9948 14 in in IN cord-010119-t1x9gknd 9948 15 Colombia Colombia NNP cord-010119-t1x9gknd 9948 16 could could MD cord-010119-t1x9gknd 9948 17 be be VB cord-010119-t1x9gknd 9948 18 improved improve VBN cord-010119-t1x9gknd 9948 19 not not RB cord-010119-t1x9gknd 9948 20 only only RB cord-010119-t1x9gknd 9948 21 by by IN cord-010119-t1x9gknd 9948 22 using use VBG cord-010119-t1x9gknd 9948 23 high high JJ cord-010119-t1x9gknd 9948 24 S S NNP cord-010119-t1x9gknd 9948 25 / / SYM cord-010119-t1x9gknd 9948 26 CO CO NNP cord-010119-t1x9gknd 9948 27 ratios ratio NNS cord-010119-t1x9gknd 9948 28 as as IN cord-010119-t1x9gknd 9948 29 an an DT cord-010119-t1x9gknd 9948 30 alternative alternative NN cord-010119-t1x9gknd 9948 31 to to IN cord-010119-t1x9gknd 9948 32 immunoblot immunoblot NNP cord-010119-t1x9gknd 9948 33 , , , cord-010119-t1x9gknd 9948 34 but but CC cord-010119-t1x9gknd 9948 35 also also RB cord-010119-t1x9gknd 9948 36 by by IN cord-010119-t1x9gknd 9948 37 introducing introduce VBG cord-010119-t1x9gknd 9948 38 HCV HCV NNP cord-010119-t1x9gknd 9948 39 genomic genomic JJ cord-010119-t1x9gknd 9948 40 assays assay NNS cord-010119-t1x9gknd 9948 41 instead instead RB cord-010119-t1x9gknd 9948 42 of of IN cord-010119-t1x9gknd 9948 43 immunoblots immunoblot NNS cord-010119-t1x9gknd 9948 44 , , , cord-010119-t1x9gknd 9948 45 at at IN cord-010119-t1x9gknd 9948 46 least least JJS cord-010119-t1x9gknd 9948 47 for for IN cord-010119-t1x9gknd 9948 48 samples sample NNS cord-010119-t1x9gknd 9948 49 with with IN cord-010119-t1x9gknd 9948 50 intermediate intermediate JJ cord-010119-t1x9gknd 9948 51 S S NNP cord-010119-t1x9gknd 9948 52 / / SYM cord-010119-t1x9gknd 9948 53 CO CO NNP cord-010119-t1x9gknd 9948 54 ratios ratio NNS cord-010119-t1x9gknd 9948 55 . . . cord-010119-t1x9gknd 9949 1 NS3_1 NS3_1 NNS cord-010119-t1x9gknd 9949 2 and and CC cord-010119-t1x9gknd 9949 3 NS3_2 ns3_2 JJ cord-010119-t1x9gknd 9949 4 cross cross NN cord-010119-t1x9gknd 9949 5 - - NN cord-010119-t1x9gknd 9949 6 reactivity reactivity NN cord-010119-t1x9gknd 9949 7 in in IN cord-010119-t1x9gknd 9949 8 Colombian colombian JJ cord-010119-t1x9gknd 9949 9 population population NN cord-010119-t1x9gknd 9949 10 warrants warrant NNS cord-010119-t1x9gknd 9949 11 further further JJ cord-010119-t1x9gknd 9949 12 investigation investigation NN cord-010119-t1x9gknd 9949 13 . . . cord-010119-t1x9gknd 9950 1 Performance performance NN cord-010119-t1x9gknd 9950 2 of of IN cord-010119-t1x9gknd 9950 3 the the DT cord-010119-t1x9gknd 9950 4 Alinity Alinity NNP cord-010119-t1x9gknd 9950 5 s s NNP cord-010119-t1x9gknd 9950 6 Immunoassay Immunoassay NNP cord-010119-t1x9gknd 9950 7 for for IN cord-010119-t1x9gknd 9950 8 the the DT cord-010119-t1x9gknd 9950 9 Detection detection NN cord-010119-t1x9gknd 9950 10 of of IN cord-010119-t1x9gknd 9950 11 Syphilis Syphilis NNP cord-010119-t1x9gknd 9950 12 Antibodies Antibodies NNP cord-010119-t1x9gknd 9950 13 Melanie Melanie NNP cord-010119-t1x9gknd 9950 14 Anderson Anderson NNP cord-010119-t1x9gknd 9950 15 * * NFP cord-010119-t1x9gknd 9950 16 1 1 CD cord-010119-t1x9gknd 9950 17 , , , cord-010119-t1x9gknd 9950 18 Ivanka Ivanka NNP cord-010119-t1x9gknd 9950 19 Mihaljevic Mihaljevic NNP cord-010119-t1x9gknd 9950 20 2 2 CD cord-010119-t1x9gknd 9950 21 , , , cord-010119-t1x9gknd 9950 22 Manuela Manuela NNP cord-010119-t1x9gknd 9950 23 Miletic Miletic NNP cord-010119-t1x9gknd 9950 24 2 2 CD cord-010119-t1x9gknd 9950 25 , , , cord-010119-t1x9gknd 9950 26 Miljana Miljana NNP cord-010119-t1x9gknd 9950 27 Stojic Stojic NNP cord-010119-t1x9gknd 9950 28 Vidovic Vidovic NNP cord-010119-t1x9gknd 9950 29 2 2 CD cord-010119-t1x9gknd 9950 30 , , , cord-010119-t1x9gknd 9950 31 Irena Irena NNP cord-010119-t1x9gknd 9950 32 Jukic Jukic NNP cord-010119-t1x9gknd 9950 33 2 2 CD cord-010119-t1x9gknd 9950 34 , , , cord-010119-t1x9gknd 9950 35 Jane Jane NNP cord-010119-t1x9gknd 9950 36 Bryant Bryant NNP cord-010119-t1x9gknd 9950 37 1 1 CD cord-010119-t1x9gknd 9950 38 , , , cord-010119-t1x9gknd 9950 39 Mark Mark NNP cord-010119-t1x9gknd 9950 40 Paradowski Paradowski NNP cord-010119-t1x9gknd 9950 41 1 1 CD cord-010119-t1x9gknd 9950 42 , , , cord-010119-t1x9gknd 9950 43 Angela Angela NNP cord-010119-t1x9gknd 9950 44 Vockel Vockel NNP cord-010119-t1x9gknd 9950 45 3 3 CD cord-010119-t1x9gknd 9950 46 , , , cord-010119-t1x9gknd 9950 47 George George NNP cord-010119-t1x9gknd 9950 48 Chen Chen NNP cord-010119-t1x9gknd 9950 49 1 1 CD cord-010119-t1x9gknd 9950 50 , , , cord-010119-t1x9gknd 9950 51 Gregg Gregg NNP cord-010119-t1x9gknd 9950 52 Williams Williams NNP cord-010119-t1x9gknd 9950 53 1 1 CD cord-010119-t1x9gknd 9950 54 and and CC cord-010119-t1x9gknd 9950 55 George George NNP cord-010119-t1x9gknd 9950 56 Schlauder Schlauder NNP cord-010119-t1x9gknd 9950 57 4 4 CD cord-010119-t1x9gknd 9950 58 . . . cord-010119-t1x9gknd 9951 1 1 1 LS cord-010119-t1x9gknd 9952 1 Abbott Abbott NNP cord-010119-t1x9gknd 9952 2 Laboratories Laboratories NNP cord-010119-t1x9gknd 9952 3 , , , cord-010119-t1x9gknd 9952 4 2 2 CD cord-010119-t1x9gknd 9952 5 Croatian Croatian NNP cord-010119-t1x9gknd 9952 6 Institute Institute NNP cord-010119-t1x9gknd 9952 7 of of IN cord-010119-t1x9gknd 9952 8 Transfusion Transfusion NNP cord-010119-t1x9gknd 9952 9 Medicine Medicine NNP cord-010119-t1x9gknd 9952 10 , , , cord-010119-t1x9gknd 9952 11 3 3 CD cord-010119-t1x9gknd 9952 12 Abbott Abbott NNP cord-010119-t1x9gknd 9952 13 GmbH GmbH NNP cord-010119-t1x9gknd 9952 14 & & CC cord-010119-t1x9gknd 9952 15 Co. Co. NNP cord-010119-t1x9gknd 9952 16 KG KG NNP cord-010119-t1x9gknd 9952 17 , , , cord-010119-t1x9gknd 9952 18 4 4 CD cord-010119-t1x9gknd 9952 19 Abbott Abbott NNP cord-010119-t1x9gknd 9952 20 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 9952 21 Background Background NNP cord-010119-t1x9gknd 9952 22 / / SYM cord-010119-t1x9gknd 9952 23 Case Case NNP cord-010119-t1x9gknd 9952 24 Studies Studies NNPS cord-010119-t1x9gknd 9952 25 : : : cord-010119-t1x9gknd 9952 26 Blood blood NN cord-010119-t1x9gknd 9952 27 donations donation NNS cord-010119-t1x9gknd 9952 28 are be VBP cord-010119-t1x9gknd 9952 29 commonly commonly RB cord-010119-t1x9gknd 9952 30 screened screen VBN cord-010119-t1x9gknd 9952 31 for for IN cord-010119-t1x9gknd 9952 32 Syphilis Syphilis NNP cord-010119-t1x9gknd 9952 33 in in IN cord-010119-t1x9gknd 9952 34 order order NN cord-010119-t1x9gknd 9952 35 to to TO cord-010119-t1x9gknd 9952 36 detect detect VB cord-010119-t1x9gknd 9952 37 the the DT cord-010119-t1x9gknd 9952 38 presence presence NN cord-010119-t1x9gknd 9952 39 of of IN cord-010119-t1x9gknd 9952 40 antibodies antibody NNS cord-010119-t1x9gknd 9952 41 to to IN cord-010119-t1x9gknd 9952 42 the the DT cord-010119-t1x9gknd 9952 43 bacterium bacterium NN cord-010119-t1x9gknd 9952 44 Treponema Treponema NNP cord-010119-t1x9gknd 9952 45 pallidum pallidum NN cord-010119-t1x9gknd 9952 46 . . . cord-010119-t1x9gknd 9953 1 In in IN cord-010119-t1x9gknd 9953 2 addition addition NN cord-010119-t1x9gknd 9953 3 , , , cord-010119-t1x9gknd 9953 4 continued continue VBN cord-010119-t1x9gknd 9953 5 pressures pressure NNS cord-010119-t1x9gknd 9953 6 on on IN cord-010119-t1x9gknd 9953 7 laboratory laboratory NN cord-010119-t1x9gknd 9953 8 operations operation NNS cord-010119-t1x9gknd 9953 9 demand demand VBP cord-010119-t1x9gknd 9953 10 that that IN cord-010119-t1x9gknd 9953 11 the the DT cord-010119-t1x9gknd 9953 12 full full JJ cord-010119-t1x9gknd 9953 13 panel panel NN cord-010119-t1x9gknd 9953 14 of of IN cord-010119-t1x9gknd 9953 15 TTID TTID NNP cord-010119-t1x9gknd 9953 16 assays assay NNS cord-010119-t1x9gknd 9953 17 perform perform VBP cord-010119-t1x9gknd 9953 18 on on IN cord-010119-t1x9gknd 9953 19 a a DT cord-010119-t1x9gknd 9953 20 single single JJ cord-010119-t1x9gknd 9953 21 platform platform NN cord-010119-t1x9gknd 9953 22 capable capable JJ cord-010119-t1x9gknd 9953 23 of of IN cord-010119-t1x9gknd 9953 24 increased increase VBN cord-010119-t1x9gknd 9953 25 walk walk NN cord-010119-t1x9gknd 9953 26 away away RB cord-010119-t1x9gknd 9953 27 time time NN cord-010119-t1x9gknd 9953 28 and and CC cord-010119-t1x9gknd 9953 29 enhanced enhanced JJ cord-010119-t1x9gknd 9953 30 automation automation NN cord-010119-t1x9gknd 9953 31 in in IN cord-010119-t1x9gknd 9953 32 areas area NNS cord-010119-t1x9gknd 9953 33 of of IN cord-010119-t1x9gknd 9953 34 reagent reagent NN cord-010119-t1x9gknd 9953 35 management management NN cord-010119-t1x9gknd 9953 36 , , , cord-010119-t1x9gknd 9953 37 retest retest VB cord-010119-t1x9gknd 9953 38 options option NNS cord-010119-t1x9gknd 9953 39 , , , cord-010119-t1x9gknd 9953 40 and and CC cord-010119-t1x9gknd 9953 41 commodity commodity NN cord-010119-t1x9gknd 9953 42 / / SYM cord-010119-t1x9gknd 9953 43 waste waste NN cord-010119-t1x9gknd 9953 44 management management NN cord-010119-t1x9gknd 9953 45 . . . cord-010119-t1x9gknd 9954 1 In in IN cord-010119-t1x9gknd 9954 2 response response NN cord-010119-t1x9gknd 9954 3 to to IN cord-010119-t1x9gknd 9954 4 those those DT cord-010119-t1x9gknd 9954 5 needs need NNS cord-010119-t1x9gknd 9954 6 , , , cord-010119-t1x9gknd 9954 7 we -PRON- PRP cord-010119-t1x9gknd 9954 8 have have VBP cord-010119-t1x9gknd 9954 9 evaluated evaluate VBN cord-010119-t1x9gknd 9954 10 a a DT cord-010119-t1x9gknd 9954 11 new new JJ cord-010119-t1x9gknd 9954 12 automated automate VBN cord-010119-t1x9gknd 9954 13 immunoassay immunoassay NN cord-010119-t1x9gknd 9954 14 for for IN cord-010119-t1x9gknd 9954 15 the the DT cord-010119-t1x9gknd 9954 16 detection detection NN cord-010119-t1x9gknd 9954 17 of of IN cord-010119-t1x9gknd 9954 18 antibodies antibody NNS cord-010119-t1x9gknd 9954 19 to to IN cord-010119-t1x9gknd 9954 20 T. T. NNP cord-010119-t1x9gknd 9954 21 pallidum pallidum NN cord-010119-t1x9gknd 9954 22 . . . cord-010119-t1x9gknd 9955 1 Study Study NNP cord-010119-t1x9gknd 9955 2 Design Design NNP cord-010119-t1x9gknd 9955 3 / / SYM cord-010119-t1x9gknd 9955 4 Method method NN cord-010119-t1x9gknd 9955 5 : : : cord-010119-t1x9gknd 9956 1 Performance performance NN cord-010119-t1x9gknd 9956 2 of of IN cord-010119-t1x9gknd 9956 3 the the DT cord-010119-t1x9gknd 9956 4 new new JJ cord-010119-t1x9gknd 9956 5 automated automate VBN cord-010119-t1x9gknd 9956 6 chemiluminescence chemiluminescence NN cord-010119-t1x9gknd 9956 7 immunoassay immunoassay NN cord-010119-t1x9gknd 9956 8 for for IN cord-010119-t1x9gknd 9956 9 the the DT cord-010119-t1x9gknd 9956 10 detection detection NN cord-010119-t1x9gknd 9956 11 of of IN cord-010119-t1x9gknd 9956 12 antibodies antibody NNS cord-010119-t1x9gknd 9956 13 to to IN cord-010119-t1x9gknd 9956 14 Treponema Treponema NNP cord-010119-t1x9gknd 9956 15 pallidum pallidum NN cord-010119-t1x9gknd 9956 16 was be VBD cord-010119-t1x9gknd 9956 17 evaluated evaluate VBN cord-010119-t1x9gknd 9956 18 on on IN cord-010119-t1x9gknd 9956 19 the the DT cord-010119-t1x9gknd 9956 20 Alinity Alinity NNP cord-010119-t1x9gknd 9956 21 s s POS cord-010119-t1x9gknd 9956 22 System System NNP cord-010119-t1x9gknd 9956 23 . . . cord-010119-t1x9gknd 9957 1 Precision precision NN cord-010119-t1x9gknd 9957 2 was be VBD cord-010119-t1x9gknd 9957 3 assessed assess VBN cord-010119-t1x9gknd 9957 4 over over IN cord-010119-t1x9gknd 9957 5 20 20 CD cord-010119-t1x9gknd 9957 6 days day NNS cord-010119-t1x9gknd 9957 7 using use VBG cord-010119-t1x9gknd 9957 8 positive positive JJ cord-010119-t1x9gknd 9957 9 samples sample NNS cord-010119-t1x9gknd 9957 10 . . . cord-010119-t1x9gknd 9958 1 Specificity specificity NN cord-010119-t1x9gknd 9958 2 was be VBD cord-010119-t1x9gknd 9958 3 evaluated evaluate VBN cord-010119-t1x9gknd 9958 4 on on IN cord-010119-t1x9gknd 9958 5 samples sample NNS cord-010119-t1x9gknd 9958 6 obtained obtain VBN cord-010119-t1x9gknd 9958 7 from from IN cord-010119-t1x9gknd 9958 8 9,101 9,101 CD cord-010119-t1x9gknd 9958 9 blood blood NN cord-010119-t1x9gknd 9958 10 and and CC cord-010119-t1x9gknd 9958 11 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 9958 12 donors donor NNS cord-010119-t1x9gknd 9958 13 from from IN cord-010119-t1x9gknd 9958 14 the the DT cord-010119-t1x9gknd 9958 15 United United NNP cord-010119-t1x9gknd 9958 16 States States NNP cord-010119-t1x9gknd 9958 17 and and CC cord-010119-t1x9gknd 9958 18 Europe Europe NNP cord-010119-t1x9gknd 9958 19 and and CC cord-010119-t1x9gknd 9958 20 200 200 CD cord-010119-t1x9gknd 9958 21 diagnostic diagnostic JJ cord-010119-t1x9gknd 9958 22 samples sample NNS cord-010119-t1x9gknd 9958 23 obtained obtain VBN cord-010119-t1x9gknd 9958 24 from from IN cord-010119-t1x9gknd 9958 25 the the DT cord-010119-t1x9gknd 9958 26 United United NNP cord-010119-t1x9gknd 9958 27 States States NNP cord-010119-t1x9gknd 9958 28 . . . cord-010119-t1x9gknd 9959 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9959 2 was be VBD cord-010119-t1x9gknd 9959 3 evaluated evaluate VBN cord-010119-t1x9gknd 9959 4 using use VBG cord-010119-t1x9gknd 9959 5 514 514 CD cord-010119-t1x9gknd 9959 6 preselected preselected JJ cord-010119-t1x9gknd 9959 7 positive positive JJ cord-010119-t1x9gknd 9959 8 samples sample NNS cord-010119-t1x9gknd 9959 9 . . . cord-010119-t1x9gknd 9960 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9960 2 and and CC cord-010119-t1x9gknd 9960 3 specificity specificity NN cord-010119-t1x9gknd 9960 4 samples sample NNS cord-010119-t1x9gknd 9960 5 were be VBD cord-010119-t1x9gknd 9960 6 split split VBN cord-010119-t1x9gknd 9960 7 across across IN cord-010119-t1x9gknd 9960 8 3 3 CD cord-010119-t1x9gknd 9960 9 reagent reagent NN cord-010119-t1x9gknd 9960 10 lots lot NNS cord-010119-t1x9gknd 9960 11 during during IN cord-010119-t1x9gknd 9960 12 testing testing NN cord-010119-t1x9gknd 9960 13 . . . cord-010119-t1x9gknd 9961 1 Confirmation confirmation NN cord-010119-t1x9gknd 9961 2 of of IN cord-010119-t1x9gknd 9961 3 repeatedly repeatedly RB cord-010119-t1x9gknd 9961 4 reactive reactive JJ cord-010119-t1x9gknd 9961 5 samples sample NNS cord-010119-t1x9gknd 9961 6 was be VBD cord-010119-t1x9gknd 9961 7 done do VBN cord-010119-t1x9gknd 9961 8 using use VBG cord-010119-t1x9gknd 9961 9 a a DT cord-010119-t1x9gknd 9961 10 testing testing NN cord-010119-t1x9gknd 9961 11 algorithm algorithm NN cord-010119-t1x9gknd 9961 12 with with IN cord-010119-t1x9gknd 9961 13 3 3 CD cord-010119-t1x9gknd 9961 14 confirmatory confirmatory JJ cord-010119-t1x9gknd 9961 15 assays assay NNS cord-010119-t1x9gknd 9961 16 , , , cord-010119-t1x9gknd 9961 17 INNO INNO NNP cord-010119-t1x9gknd 9961 18 - - HYPH cord-010119-t1x9gknd 9961 19 LIA LIA NNP cord-010119-t1x9gknd 9961 20 TM TM NNP cord-010119-t1x9gknd 9961 21 Syphilis Syphilis NNP cord-010119-t1x9gknd 9961 22 Score Score NNP cord-010119-t1x9gknd 9961 23 , , , cord-010119-t1x9gknd 9961 24 and and CC cord-010119-t1x9gknd 9961 25 Mikrogen Mikrogen NNP cord-010119-t1x9gknd 9961 26 recomLine recomLine NNP cord-010119-t1x9gknd 9961 27 Treponema Treponema NNP cord-010119-t1x9gknd 9961 28 IgG igg NN cord-010119-t1x9gknd 9961 29 and and CC cord-010119-t1x9gknd 9961 30 IgM IgM NNP cord-010119-t1x9gknd 9961 31 blots blot NNS cord-010119-t1x9gknd 9961 32 . . . cord-010119-t1x9gknd 9962 1 Results/ Results/ . cord-010119-t1x9gknd 9963 1 Finding finding NN cord-010119-t1x9gknd 9963 2 : : : cord-010119-t1x9gknd 9964 1 Imprecision imprecision NN cord-010119-t1x9gknd 9964 2 was be VBD cord-010119-t1x9gknd 9964 3 less less JJR cord-010119-t1x9gknd 9964 4 than than IN cord-010119-t1x9gknd 9964 5 6.0 6.0 CD cord-010119-t1x9gknd 9964 6 % % NN cord-010119-t1x9gknd 9964 7 CV cv NN cord-010119-t1x9gknd 9964 8 for for IN cord-010119-t1x9gknd 9964 9 positive positive JJ cord-010119-t1x9gknd 9964 10 samples sample NNS cord-010119-t1x9gknd 9964 11 over over IN cord-010119-t1x9gknd 9964 12 20 20 CD cord-010119-t1x9gknd 9964 13 days day NNS cord-010119-t1x9gknd 9964 14 . . . cord-010119-t1x9gknd 9965 1 Clinical clinical JJ cord-010119-t1x9gknd 9965 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9965 3 was be VBD cord-010119-t1x9gknd 9965 4 100.00 100.00 CD cord-010119-t1x9gknd 9965 5 % % NN cord-010119-t1x9gknd 9965 6 ( ( -LRB- cord-010119-t1x9gknd 9965 7 514/514 514/514 CD cord-010119-t1x9gknd 9965 8 ) ) -RRB- cord-010119-t1x9gknd 9965 9 on on IN cord-010119-t1x9gknd 9965 10 preselected preselecte VBN cord-010119-t1x9gknd 9965 11 Syphilis Syphilis NNP cord-010119-t1x9gknd 9965 12 positive positive JJ cord-010119-t1x9gknd 9965 13 samples sample NNS cord-010119-t1x9gknd 9965 14 . . . cord-010119-t1x9gknd 9966 1 The the DT cord-010119-t1x9gknd 9966 2 specificity specificity NN cord-010119-t1x9gknd 9966 3 was be VBD cord-010119-t1x9gknd 9966 4 99.97 99.97 CD cord-010119-t1x9gknd 9966 5 % % NN cord-010119-t1x9gknd 9966 6 ( ( -LRB- cord-010119-t1x9gknd 9966 7 9,063/9,066 9,063/9,066 CD cord-010119-t1x9gknd 9966 8 ) ) -RRB- cord-010119-t1x9gknd 9966 9 for for IN cord-010119-t1x9gknd 9966 10 blood blood NN cord-010119-t1x9gknd 9966 11 donor donor NN cord-010119-t1x9gknd 9966 12 specimens specimen NNS cord-010119-t1x9gknd 9966 13 and and CC cord-010119-t1x9gknd 9966 14 100.00 100.00 CD cord-010119-t1x9gknd 9966 15 % % NN cord-010119-t1x9gknd 9966 16 ( ( -LRB- cord-010119-t1x9gknd 9966 17 200/200 200/200 NNP cord-010119-t1x9gknd 9966 18 ) ) -RRB- cord-010119-t1x9gknd 9966 19 on on IN cord-010119-t1x9gknd 9966 20 diagnostic diagnostic JJ cord-010119-t1x9gknd 9966 21 samples sample NNS cord-010119-t1x9gknd 9966 22 . . . cord-010119-t1x9gknd 9967 1 Conclusion conclusion NN cord-010119-t1x9gknd 9967 2 : : : cord-010119-t1x9gknd 9968 1 These these DT cord-010119-t1x9gknd 9968 2 results result NNS cord-010119-t1x9gknd 9968 3 indicate indicate VBP cord-010119-t1x9gknd 9968 4 that that IN cord-010119-t1x9gknd 9968 5 the the DT cord-010119-t1x9gknd 9968 6 new new JJ cord-010119-t1x9gknd 9968 7 automated automate VBN cord-010119-t1x9gknd 9968 8 Alinity Alinity NNP cord-010119-t1x9gknd 9968 9 s s POS cord-010119-t1x9gknd 9968 10 Syphilis Syphilis NNP cord-010119-t1x9gknd 9968 11 assay assay NN cord-010119-t1x9gknd 9968 12 provided provide VBD cord-010119-t1x9gknd 9968 13 good good JJ cord-010119-t1x9gknd 9968 14 performance performance NN cord-010119-t1x9gknd 9968 15 in in IN cord-010119-t1x9gknd 9968 16 precision precision NN cord-010119-t1x9gknd 9968 17 , , , cord-010119-t1x9gknd 9968 18 specificity specificity NN cord-010119-t1x9gknd 9968 19 and and CC cord-010119-t1x9gknd 9968 20 sensitivity sensitivity NN cord-010119-t1x9gknd 9968 21 in in IN cord-010119-t1x9gknd 9968 22 line line NN cord-010119-t1x9gknd 9968 23 with with IN cord-010119-t1x9gknd 9968 24 data datum NNS cord-010119-t1x9gknd 9968 25 found find VBN cord-010119-t1x9gknd 9968 26 for for IN cord-010119-t1x9gknd 9968 27 the the DT cord-010119-t1x9gknd 9968 28 comparator comparator NN cord-010119-t1x9gknd 9968 29 assay assay NN cord-010119-t1x9gknd 9968 30 . . . cord-010119-t1x9gknd 9969 1 Performance performance NN cord-010119-t1x9gknd 9969 2 of of IN cord-010119-t1x9gknd 9969 3 the the DT cord-010119-t1x9gknd 9969 4 New New NNP cord-010119-t1x9gknd 9969 5 Automated Automated NNP cord-010119-t1x9gknd 9969 6 Alinity Alinity NNP cord-010119-t1x9gknd 9969 7 s s POS cord-010119-t1x9gknd 9969 8 Assay Assay NNP cord-010119-t1x9gknd 9969 9 for for IN cord-010119-t1x9gknd 9969 10 Anti Anti NNP cord-010119-t1x9gknd 9969 11 - - NNP cord-010119-t1x9gknd 9969 12 HCV HCV NNP cord-010119-t1x9gknd 9969 13 Melanie Melanie NNP cord-010119-t1x9gknd 9969 14 Anderson Anderson NNP cord-010119-t1x9gknd 9970 1 * * NFP cord-010119-t1x9gknd 9970 2 1 1 CD cord-010119-t1x9gknd 9970 3 , , , cord-010119-t1x9gknd 9970 4 Ed Ed NNP cord-010119-t1x9gknd 9970 5 Bakker Bakker NNP cord-010119-t1x9gknd 9970 6 2 2 CD cord-010119-t1x9gknd 9970 7 , , , cord-010119-t1x9gknd 9970 8 Anton Anton NNP cord-010119-t1x9gknd 9970 9 vanWeert vanWeert NNP cord-010119-t1x9gknd 9970 10 2 2 CD cord-010119-t1x9gknd 9970 11 , , , cord-010119-t1x9gknd 9970 12 Jane Jane NNP cord-010119-t1x9gknd 9970 13 Bryant Bryant NNP cord-010119-t1x9gknd 9970 14 1 1 CD cord-010119-t1x9gknd 9970 15 , , , cord-010119-t1x9gknd 9970 16 Mark Mark NNP cord-010119-t1x9gknd 9970 17 Paradowski Paradowski NNP cord-010119-t1x9gknd 9970 18 1 1 CD cord-010119-t1x9gknd 9970 19 , , , cord-010119-t1x9gknd 9970 20 Tuan Tuan NNP cord-010119-t1x9gknd 9970 21 Bui Bui NNP cord-010119-t1x9gknd 9970 22 1 1 CD cord-010119-t1x9gknd 9970 23 , , , cord-010119-t1x9gknd 9970 24 Lynn Lynn NNP cord-010119-t1x9gknd 9970 25 Martin Martin NNP cord-010119-t1x9gknd 9970 26 1 1 CD cord-010119-t1x9gknd 9970 27 , , , cord-010119-t1x9gknd 9970 28 George George NNP cord-010119-t1x9gknd 9970 29 Chen Chen NNP cord-010119-t1x9gknd 9970 30 1 1 CD cord-010119-t1x9gknd 9970 31 , , , cord-010119-t1x9gknd 9970 32 Gregg Gregg NNP cord-010119-t1x9gknd 9970 33 Williams Williams NNP cord-010119-t1x9gknd 9970 34 1 1 CD cord-010119-t1x9gknd 9970 35 and and CC cord-010119-t1x9gknd 9970 36 George George NNP cord-010119-t1x9gknd 9970 37 Schlauder Schlauder NNP cord-010119-t1x9gknd 9970 38 3 3 CD cord-010119-t1x9gknd 9970 39 . . . cord-010119-t1x9gknd 9971 1 1 1 LS cord-010119-t1x9gknd 9972 1 Abbott Abbott NNP cord-010119-t1x9gknd 9972 2 Laboratories Laboratories NNP cord-010119-t1x9gknd 9972 3 , , , cord-010119-t1x9gknd 9972 4 2 2 CD cord-010119-t1x9gknd 9972 5 Sanguin Sanguin NNP cord-010119-t1x9gknd 9972 6 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 9972 7 , , , cord-010119-t1x9gknd 9972 8 3 3 CD cord-010119-t1x9gknd 9972 9 _SP cord-010119-t1x9gknd 9972 10 Background Background NNP cord-010119-t1x9gknd 9972 11 / / SYM cord-010119-t1x9gknd 9972 12 Case Case NNP cord-010119-t1x9gknd 9972 13 Studies Studies NNPS cord-010119-t1x9gknd 9972 14 : : : cord-010119-t1x9gknd 9972 15 Serological serological JJ cord-010119-t1x9gknd 9972 16 screening screening NN cord-010119-t1x9gknd 9972 17 for for IN cord-010119-t1x9gknd 9972 18 antibodies antibody NNS cord-010119-t1x9gknd 9972 19 to to IN cord-010119-t1x9gknd 9972 20 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 9972 21 C C NNP cord-010119-t1x9gknd 9972 22 virus virus NN cord-010119-t1x9gknd 9972 23 ( ( -LRB- cord-010119-t1x9gknd 9972 24 HCV HCV NNP cord-010119-t1x9gknd 9972 25 ) ) -RRB- cord-010119-t1x9gknd 9972 26 often often RB cord-010119-t1x9gknd 9972 27 in in IN cord-010119-t1x9gknd 9972 28 conjunction conjunction NN cord-010119-t1x9gknd 9972 29 with with IN cord-010119-t1x9gknd 9972 30 nucleic nucleic JJ cord-010119-t1x9gknd 9972 31 acid acid NN cord-010119-t1x9gknd 9972 32 testing testing NN cord-010119-t1x9gknd 9972 33 ( ( -LRB- cord-010119-t1x9gknd 9972 34 NAT NAT NNP cord-010119-t1x9gknd 9972 35 ) ) -RRB- cord-010119-t1x9gknd 9972 36 is be VBZ cord-010119-t1x9gknd 9972 37 used use VBN cord-010119-t1x9gknd 9972 38 worldwide worldwide RB cord-010119-t1x9gknd 9972 39 to to TO cord-010119-t1x9gknd 9972 40 prevent prevent VB cord-010119-t1x9gknd 9972 41 transfusion transfusion NN cord-010119-t1x9gknd 9972 42 transmitted transmit VBN cord-010119-t1x9gknd 9972 43 HCV HCV NNP cord-010119-t1x9gknd 9972 44 infections infection NNS cord-010119-t1x9gknd 9972 45 . . . cord-010119-t1x9gknd 9973 1 While while IN cord-010119-t1x9gknd 9973 2 NAT NAT NNP cord-010119-t1x9gknd 9973 3 provides provide VBZ cord-010119-t1x9gknd 9973 4 improved improve VBN cord-010119-t1x9gknd 9973 5 sensitivity sensitivity NN cord-010119-t1x9gknd 9973 6 and and CC cord-010119-t1x9gknd 9973 7 detection detection NN cord-010119-t1x9gknd 9973 8 of of IN cord-010119-t1x9gknd 9973 9 HCV HCV NNP cord-010119-t1x9gknd 9973 10 in in IN cord-010119-t1x9gknd 9973 11 the the DT cord-010119-t1x9gknd 9973 12 pre pre JJ cord-010119-t1x9gknd 9973 13 - - JJ cord-010119-t1x9gknd 9973 14 seroconversion seroconversion JJ cord-010119-t1x9gknd 9973 15 window window NN cord-010119-t1x9gknd 9973 16 , , , cord-010119-t1x9gknd 9973 17 serological serological JJ cord-010119-t1x9gknd 9973 18 testing testing NN cord-010119-t1x9gknd 9973 19 provides provide VBZ cord-010119-t1x9gknd 9973 20 continued continued JJ cord-010119-t1x9gknd 9973 21 detection detection NN cord-010119-t1x9gknd 9973 22 of of IN cord-010119-t1x9gknd 9973 23 HCV HCV NNP cord-010119-t1x9gknd 9973 24 in in IN cord-010119-t1x9gknd 9973 25 infected infected JJ cord-010119-t1x9gknd 9973 26 individuals individual NNS cord-010119-t1x9gknd 9973 27 and and CC cord-010119-t1x9gknd 9973 28 individuals individual NNS cord-010119-t1x9gknd 9973 29 with with IN cord-010119-t1x9gknd 9973 30 resolved resolve VBN cord-010119-t1x9gknd 9973 31 infections infection NNS cord-010119-t1x9gknd 9973 32 with with IN cord-010119-t1x9gknd 9973 33 no no DT cord-010119-t1x9gknd 9973 34 detectable detectable JJ cord-010119-t1x9gknd 9973 35 HCV HCV NNP cord-010119-t1x9gknd 9973 36 RNA RNA NNP cord-010119-t1x9gknd 9973 37 . . . cord-010119-t1x9gknd 9974 1 Blood blood NN cord-010119-t1x9gknd 9974 2 and and CC cord-010119-t1x9gknd 9974 3 plasma plasma NN cord-010119-t1x9gknd 9974 4 centers center NNS cord-010119-t1x9gknd 9974 5 require require VBP cord-010119-t1x9gknd 9974 6 very very RB cord-010119-t1x9gknd 9974 7 high high JJ cord-010119-t1x9gknd 9974 8 throughput throughput NN cord-010119-t1x9gknd 9974 9 anti anti JJ cord-010119-t1x9gknd 9974 10 - - JJ cord-010119-t1x9gknd 9974 11 HCV hcv JJ cord-010119-t1x9gknd 9974 12 assays assay NNS cord-010119-t1x9gknd 9974 13 with with IN cord-010119-t1x9gknd 9974 14 high high JJ cord-010119-t1x9gknd 9974 15 specificity specificity NN cord-010119-t1x9gknd 9974 16 and and CC cord-010119-t1x9gknd 9974 17 sensitivity sensitivity NN cord-010119-t1x9gknd 9974 18 to to TO cord-010119-t1x9gknd 9974 19 prevent prevent VB cord-010119-t1x9gknd 9974 20 unnecessary unnecessary JJ cord-010119-t1x9gknd 9974 21 donor donor NN cord-010119-t1x9gknd 9974 22 deferrals deferral NNS cord-010119-t1x9gknd 9974 23 while while IN cord-010119-t1x9gknd 9974 24 maintaining maintain VBG cord-010119-t1x9gknd 9974 25 the the DT cord-010119-t1x9gknd 9974 26 safety safety NN cord-010119-t1x9gknd 9974 27 of of IN cord-010119-t1x9gknd 9974 28 the the DT cord-010119-t1x9gknd 9974 29 blood blood NN cord-010119-t1x9gknd 9974 30 and and CC cord-010119-t1x9gknd 9974 31 plasma plasma NN cord-010119-t1x9gknd 9974 32 supply supply NN cord-010119-t1x9gknd 9974 33 . . . cord-010119-t1x9gknd 9975 1 In in IN cord-010119-t1x9gknd 9975 2 addition addition NN cord-010119-t1x9gknd 9975 3 , , , cord-010119-t1x9gknd 9975 4 continued continue VBN cord-010119-t1x9gknd 9975 5 pressures pressure NNS cord-010119-t1x9gknd 9975 6 on on IN cord-010119-t1x9gknd 9975 7 laboratory laboratory NN cord-010119-t1x9gknd 9975 8 operations operation NNS cord-010119-t1x9gknd 9975 9 demand demand VBP cord-010119-t1x9gknd 9975 10 that that IN cord-010119-t1x9gknd 9975 11 assays assay NNS cord-010119-t1x9gknd 9975 12 perform perform VBP cord-010119-t1x9gknd 9975 13 on on IN cord-010119-t1x9gknd 9975 14 platforms platform NNS cord-010119-t1x9gknd 9975 15 capable capable JJ cord-010119-t1x9gknd 9975 16 of of IN cord-010119-t1x9gknd 9975 17 increased increase VBN cord-010119-t1x9gknd 9975 18 walk walk NN cord-010119-t1x9gknd 9975 19 away away RB cord-010119-t1x9gknd 9975 20 time time NN cord-010119-t1x9gknd 9975 21 and and CC cord-010119-t1x9gknd 9975 22 enhanced enhanced JJ cord-010119-t1x9gknd 9975 23 automation automation NN cord-010119-t1x9gknd 9975 24 in in IN cord-010119-t1x9gknd 9975 25 areas area NNS cord-010119-t1x9gknd 9975 26 of of IN cord-010119-t1x9gknd 9975 27 reagent reagent NN cord-010119-t1x9gknd 9975 28 management management NN cord-010119-t1x9gknd 9975 29 , , , cord-010119-t1x9gknd 9975 30 retest retest VB cord-010119-t1x9gknd 9975 31 options option NNS cord-010119-t1x9gknd 9975 32 , , , cord-010119-t1x9gknd 9975 33 and and CC cord-010119-t1x9gknd 9975 34 commodity commodity NN cord-010119-t1x9gknd 9975 35 / / SYM cord-010119-t1x9gknd 9975 36 waste waste NN cord-010119-t1x9gknd 9975 37 management management NN cord-010119-t1x9gknd 9975 38 . . . cord-010119-t1x9gknd 9976 1 Study Study NNP cord-010119-t1x9gknd 9976 2 Design Design NNP cord-010119-t1x9gknd 9976 3 / / SYM cord-010119-t1x9gknd 9976 4 Method method NN cord-010119-t1x9gknd 9976 5 : : : cord-010119-t1x9gknd 9977 1 The the DT cord-010119-t1x9gknd 9977 2 performance performance NN cord-010119-t1x9gknd 9977 3 of of IN cord-010119-t1x9gknd 9977 4 a a DT cord-010119-t1x9gknd 9977 5 new new JJ cord-010119-t1x9gknd 9977 6 automated automate VBN cord-010119-t1x9gknd 9977 7 chemiluminescence chemiluminescence NN cord-010119-t1x9gknd 9977 8 immunoassay immunoassay NN cord-010119-t1x9gknd 9977 9 for for IN cord-010119-t1x9gknd 9977 10 the the DT cord-010119-t1x9gknd 9977 11 detection detection NN cord-010119-t1x9gknd 9977 12 of of IN cord-010119-t1x9gknd 9977 13 antibodies antibody NNS cord-010119-t1x9gknd 9977 14 to to IN cord-010119-t1x9gknd 9977 15 HCV HCV NNP cord-010119-t1x9gknd 9977 16 was be VBD cord-010119-t1x9gknd 9977 17 evaluated evaluate VBN cord-010119-t1x9gknd 9977 18 on on IN cord-010119-t1x9gknd 9977 19 the the DT cord-010119-t1x9gknd 9977 20 Alinity Alinity NNP cord-010119-t1x9gknd 9977 21 s s POS cord-010119-t1x9gknd 9977 22 System System NNP cord-010119-t1x9gknd 9977 23 . . . cord-010119-t1x9gknd 9978 1 Precision precision NN cord-010119-t1x9gknd 9978 2 was be VBD cord-010119-t1x9gknd 9978 3 assessed assess VBN cord-010119-t1x9gknd 9978 4 over over IN cord-010119-t1x9gknd 9978 5 20 20 CD cord-010119-t1x9gknd 9978 6 days day NNS cord-010119-t1x9gknd 9978 7 evaluating evaluate VBG cord-010119-t1x9gknd 9978 8 positive positive JJ cord-010119-t1x9gknd 9978 9 samples sample NNS cord-010119-t1x9gknd 9978 10 . . . cord-010119-t1x9gknd 9979 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9979 2 was be VBD cord-010119-t1x9gknd 9979 3 evaluated evaluate VBN cord-010119-t1x9gknd 9979 4 using use VBG cord-010119-t1x9gknd 9979 5 501 501 CD cord-010119-t1x9gknd 9979 6 preselected preselected JJ cord-010119-t1x9gknd 9979 7 positive positive JJ cord-010119-t1x9gknd 9979 8 samples sample NNS cord-010119-t1x9gknd 9979 9 and and CC cord-010119-t1x9gknd 9979 10 30 30 CD cord-010119-t1x9gknd 9979 11 seroconversion seroconversion NN cord-010119-t1x9gknd 9979 12 panels panel NNS cord-010119-t1x9gknd 9979 13 . . . cord-010119-t1x9gknd 9980 1 Specificity specificity NN cord-010119-t1x9gknd 9980 2 was be VBD cord-010119-t1x9gknd 9980 3 evaluated evaluate VBN cord-010119-t1x9gknd 9980 4 on on IN cord-010119-t1x9gknd 9980 5 samples sample NNS cord-010119-t1x9gknd 9980 6 obtained obtain VBN cord-010119-t1x9gknd 9980 7 from from IN cord-010119-t1x9gknd 9980 8 8,113 8,113 CD cord-010119-t1x9gknd 9980 9 blood blood NN cord-010119-t1x9gknd 9980 10 and and CC cord-010119-t1x9gknd 9980 11 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 9980 12 donors donor NNS cord-010119-t1x9gknd 9980 13 from from IN cord-010119-t1x9gknd 9980 14 the the DT cord-010119-t1x9gknd 9980 15 United United NNP cord-010119-t1x9gknd 9980 16 States States NNP cord-010119-t1x9gknd 9980 17 and and CC cord-010119-t1x9gknd 9980 18 Europe Europe NNP cord-010119-t1x9gknd 9980 19 and and CC cord-010119-t1x9gknd 9980 20 200 200 CD cord-010119-t1x9gknd 9980 21 diagnostic diagnostic JJ cord-010119-t1x9gknd 9980 22 samples sample NNS cord-010119-t1x9gknd 9980 23 obtained obtain VBN cord-010119-t1x9gknd 9980 24 from from IN cord-010119-t1x9gknd 9980 25 the the DT cord-010119-t1x9gknd 9980 26 United United NNP cord-010119-t1x9gknd 9980 27 States States NNP cord-010119-t1x9gknd 9980 28 . . . cord-010119-t1x9gknd 9981 1 Sensitivity sensitivity NN cord-010119-t1x9gknd 9981 2 and and CC cord-010119-t1x9gknd 9981 3 specificity specificity NN cord-010119-t1x9gknd 9981 4 samples sample NNS cord-010119-t1x9gknd 9981 5 were be VBD cord-010119-t1x9gknd 9981 6 split split VBN cord-010119-t1x9gknd 9981 7 across across IN cord-010119-t1x9gknd 9981 8 3 3 CD cord-010119-t1x9gknd 9981 9 reagent reagent NN cord-010119-t1x9gknd 9981 10 lots lot NNS cord-010119-t1x9gknd 9981 11 during during IN cord-010119-t1x9gknd 9981 12 testing testing NN cord-010119-t1x9gknd 9981 13 . . . cord-010119-t1x9gknd 9982 1 Confirmation confirmation NN cord-010119-t1x9gknd 9982 2 of of IN cord-010119-t1x9gknd 9982 3 repeatedly repeatedly RB cord-010119-t1x9gknd 9982 4 reactive reactive JJ cord-010119-t1x9gknd 9982 5 samples sample NNS cord-010119-t1x9gknd 9982 6 was be VBD cord-010119-t1x9gknd 9982 7 done do VBN cord-010119-t1x9gknd 9982 8 using use VBG cord-010119-t1x9gknd 9982 9 a a DT cord-010119-t1x9gknd 9982 10 testing testing NN cord-010119-t1x9gknd 9982 11 algorithm algorithm NN cord-010119-t1x9gknd 9982 12 consisting consist VBG cord-010119-t1x9gknd 9982 13 of of IN cord-010119-t1x9gknd 9982 14 the the DT cord-010119-t1x9gknd 9982 15 INNO INNO NNP cord-010119-t1x9gknd 9982 16 - - HYPH cord-010119-t1x9gknd 9982 17 LIA LIA NNP cord-010119-t1x9gknd 9982 18 TM TM NNP cord-010119-t1x9gknd 9982 19 HCV HCV NNP cord-010119-t1x9gknd 9982 20 Score Score NNP cord-010119-t1x9gknd 9982 21 and and CC cord-010119-t1x9gknd 9982 22 NAT NAT NNP cord-010119-t1x9gknd 9982 23 / / SYM cord-010119-t1x9gknd 9982 24 HCV HCV NNP cord-010119-t1x9gknd 9983 1 Discriminatory discriminatory JJ cord-010119-t1x9gknd 9983 2 NAT NAT NNP cord-010119-t1x9gknd 9983 3 assays assay NNS cord-010119-t1x9gknd 9983 4 . . . cord-010119-t1x9gknd 9984 1 Results/ Results/ . cord-010119-t1x9gknd 9985 1 Finding finding NN cord-010119-t1x9gknd 9985 2 : : : cord-010119-t1x9gknd 9986 1 Imprecision imprecision NN cord-010119-t1x9gknd 9986 2 was be VBD cord-010119-t1x9gknd 9986 3 less less JJR cord-010119-t1x9gknd 9986 4 than than IN cord-010119-t1x9gknd 9986 5 7.0 7.0 CD cord-010119-t1x9gknd 9986 6 % % NN cord-010119-t1x9gknd 9986 7 CV cv NN cord-010119-t1x9gknd 9986 8 for for IN cord-010119-t1x9gknd 9986 9 positive positive JJ cord-010119-t1x9gknd 9986 10 samples sample NNS cord-010119-t1x9gknd 9986 11 over over IN cord-010119-t1x9gknd 9986 12 20 20 CD cord-010119-t1x9gknd 9986 13 days day NNS cord-010119-t1x9gknd 9986 14 . . . cord-010119-t1x9gknd 9987 1 Overall overall JJ cord-010119-t1x9gknd 9987 2 clinical clinical JJ cord-010119-t1x9gknd 9987 3 sensitivity sensitivity NN cord-010119-t1x9gknd 9987 4 was be VBD cord-010119-t1x9gknd 9987 5 100 100 CD cord-010119-t1x9gknd 9987 6 % % NN cord-010119-t1x9gknd 9987 7 on on IN cord-010119-t1x9gknd 9987 8 501 501 CD cord-010119-t1x9gknd 9987 9 preselected preselected JJ cord-010119-t1x9gknd 9987 10 anti anti JJ cord-010119-t1x9gknd 9987 11 - - JJ cord-010119-t1x9gknd 9987 12 HCV hcv JJ cord-010119-t1x9gknd 9987 13 positive positive JJ cord-010119-t1x9gknd 9987 14 samples sample NNS cord-010119-t1x9gknd 9987 15 . . . cord-010119-t1x9gknd 9988 1 Seroconversion seroconversion NN cord-010119-t1x9gknd 9988 2 sensitivity sensitivity NN cord-010119-t1x9gknd 9988 3 was be VBD cord-010119-t1x9gknd 9988 4 better well JJR cord-010119-t1x9gknd 9988 5 than than IN cord-010119-t1x9gknd 9988 6 the the DT cord-010119-t1x9gknd 9988 7 comparator comparator NN cord-010119-t1x9gknd 9988 8 as as IN cord-010119-t1x9gknd 9988 9 evidenced evidence VBN cord-010119-t1x9gknd 9988 10 by by IN cord-010119-t1x9gknd 9988 11 the the DT cord-010119-t1x9gknd 9988 12 new new JJ cord-010119-t1x9gknd 9988 13 Anti Anti NNP cord-010119-t1x9gknd 9988 14 - - NNP cord-010119-t1x9gknd 9988 15 HCV HCV NNP cord-010119-t1x9gknd 9988 16 assay assay NN cord-010119-t1x9gknd 9988 17 identifying identify VBG cord-010119-t1x9gknd 9988 18 5 5 CD cord-010119-t1x9gknd 9988 19 more more JJR cord-010119-t1x9gknd 9988 20 bleeds bleed NNS cord-010119-t1x9gknd 9988 21 than than IN cord-010119-t1x9gknd 9988 22 the the DT cord-010119-t1x9gknd 9988 23 comparator comparator NN cord-010119-t1x9gknd 9988 24 assay assay NN cord-010119-t1x9gknd 9988 25 . . . cord-010119-t1x9gknd 9989 1 The the DT cord-010119-t1x9gknd 9989 2 specificity specificity NN cord-010119-t1x9gknd 9989 3 was be VBD cord-010119-t1x9gknd 9989 4 99.99 99.99 CD cord-010119-t1x9gknd 9989 5 % % NN cord-010119-t1x9gknd 9989 6 ( ( -LRB- cord-010119-t1x9gknd 9989 7 8,111/8,112 8,111/8,112 CD cord-010119-t1x9gknd 9989 8 ) ) -RRB- cord-010119-t1x9gknd 9989 9 for for IN cord-010119-t1x9gknd 9989 10 blood blood NN cord-010119-t1x9gknd 9989 11 donor donor NN cord-010119-t1x9gknd 9989 12 specimens specimen NNS cord-010119-t1x9gknd 9989 13 and and CC cord-010119-t1x9gknd 9989 14 98 98 CD cord-010119-t1x9gknd 9989 15 . . . cord-010119-t1x9gknd 9990 1 98 98 CD cord-010119-t1x9gknd 9990 2 % % NN cord-010119-t1x9gknd 9990 3 ( ( -LRB- cord-010119-t1x9gknd 9990 4 194/196 194/196 NNP cord-010119-t1x9gknd 9990 5 ) ) -RRB- cord-010119-t1x9gknd 9990 6 Background Background NNP cord-010119-t1x9gknd 9990 7 / / SYM cord-010119-t1x9gknd 9990 8 Case Case NNP cord-010119-t1x9gknd 9990 9 Studies Studies NNPS cord-010119-t1x9gknd 9990 10 : : : cord-010119-t1x9gknd 9990 11 ZIKA ZIKA NNP cord-010119-t1x9gknd 9990 12 virus virus NN cord-010119-t1x9gknd 9990 13 ( ( -LRB- cord-010119-t1x9gknd 9990 14 ZIKV ZIKV NNP cord-010119-t1x9gknd 9990 15 ) ) -RRB- cord-010119-t1x9gknd 9990 16 , , , cord-010119-t1x9gknd 9990 17 which which WDT cord-010119-t1x9gknd 9990 18 has have VBZ cord-010119-t1x9gknd 9990 19 been be VBN cord-010119-t1x9gknd 9990 20 outbroken outbroken VBN cord-010119-t1x9gknd 9990 21 in in IN cord-010119-t1x9gknd 9990 22 South South NNP cord-010119-t1x9gknd 9990 23 America America NNP cord-010119-t1x9gknd 9990 24 and and CC cord-010119-t1x9gknd 9990 25 the the DT cord-010119-t1x9gknd 9990 26 United United NNP cord-010119-t1x9gknd 9990 27 States States NNP cord-010119-t1x9gknd 9990 28 since since IN cord-010119-t1x9gknd 9990 29 middle middle NN cord-010119-t1x9gknd 9990 30 of of IN cord-010119-t1x9gknd 9990 31 2015 2015 CD cord-010119-t1x9gknd 9990 32 , , , cord-010119-t1x9gknd 9990 33 was be VBD cord-010119-t1x9gknd 9990 34 declared declare VBN cord-010119-t1x9gknd 9990 35 as as IN cord-010119-t1x9gknd 9990 36 the the DT cord-010119-t1x9gknd 9990 37 public public JJ cord-010119-t1x9gknd 9990 38 health health NN cord-010119-t1x9gknd 9990 39 emergency emergency NN cord-010119-t1x9gknd 9990 40 of of IN cord-010119-t1x9gknd 9990 41 international international JJ cord-010119-t1x9gknd 9990 42 concern concern NN cord-010119-t1x9gknd 9990 43 by by IN cord-010119-t1x9gknd 9990 44 WHO WHO NNP cord-010119-t1x9gknd 9990 45 in in IN cord-010119-t1x9gknd 9990 46 Feb Feb NNP cord-010119-t1x9gknd 9990 47 2016 2016 CD cord-010119-t1x9gknd 9990 48 . . . cord-010119-t1x9gknd 9991 1 In in IN cord-010119-t1x9gknd 9991 2 addition addition NN cord-010119-t1x9gknd 9991 3 to to IN cord-010119-t1x9gknd 9991 4 mosquito mosquito NN cord-010119-t1x9gknd 9991 5 , , , cord-010119-t1x9gknd 9991 6 ZIKV ZIKV NNP cord-010119-t1x9gknd 9991 7 can can MD cord-010119-t1x9gknd 9991 8 be be VB cord-010119-t1x9gknd 9991 9 transmitted transmit VBN cord-010119-t1x9gknd 9991 10 via via IN cord-010119-t1x9gknd 9991 11 maternalneonatal maternalneonatal JJ cord-010119-t1x9gknd 9991 12 relationship relationship NN cord-010119-t1x9gknd 9991 13 , , , cord-010119-t1x9gknd 9991 14 sexual sexual JJ cord-010119-t1x9gknd 9991 15 intercourse intercourse NN cord-010119-t1x9gknd 9991 16 or or CC cord-010119-t1x9gknd 9991 17 blood blood NN cord-010119-t1x9gknd 9991 18 transfusion transfusion NN cord-010119-t1x9gknd 9991 19 . . . cord-010119-t1x9gknd 9992 1 The the DT cord-010119-t1x9gknd 9992 2 potential potential NN cord-010119-t1x9gknd 9992 3 for for IN cord-010119-t1x9gknd 9992 4 transfusion transfusion NN cord-010119-t1x9gknd 9992 5 - - HYPH cord-010119-t1x9gknd 9992 6 transmitted transmit VBN cord-010119-t1x9gknd 9992 7 Zika Zika NNP cord-010119-t1x9gknd 9992 8 virus virus NN cord-010119-t1x9gknd 9992 9 was be VBD cord-010119-t1x9gknd 9992 10 shown show VBN cord-010119-t1x9gknd 9992 11 in in IN cord-010119-t1x9gknd 9992 12 French French NNP cord-010119-t1x9gknd 9992 13 Polynesia Polynesia NNP cord-010119-t1x9gknd 9992 14 where where WRB cord-010119-t1x9gknd 9992 15 2.8 2.8 CD cord-010119-t1x9gknd 9992 16 % % NN cord-010119-t1x9gknd 9992 17 of of IN cord-010119-t1x9gknd 9992 18 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 9992 19 blood blood NN cord-010119-t1x9gknd 9992 20 donors donor NNS cord-010119-t1x9gknd 9992 21 tested test VBN cord-010119-t1x9gknd 9992 22 were be VBD cord-010119-t1x9gknd 9992 23 positive positive JJ cord-010119-t1x9gknd 9992 24 for for IN cord-010119-t1x9gknd 9992 25 Zika Zika NNP cord-010119-t1x9gknd 9992 26 virus virus NN cord-010119-t1x9gknd 9992 27 RNA rna NN cord-010119-t1x9gknd 9992 28 using use VBG cord-010119-t1x9gknd 9992 29 nucleic nucleic JJ cord-010119-t1x9gknd 9992 30 acid acid NN cord-010119-t1x9gknd 9992 31 test test NN cord-010119-t1x9gknd 9992 32 ( ( -LRB- cord-010119-t1x9gknd 9992 33 NAT NAT NNP cord-010119-t1x9gknd 9992 34 ) ) -RRB- cord-010119-t1x9gknd 9992 35 . . . cord-010119-t1x9gknd 9993 1 Several several JJ cord-010119-t1x9gknd 9993 2 case case NN cord-010119-t1x9gknd 9993 3 reports report NNS cord-010119-t1x9gknd 9993 4 have have VBP cord-010119-t1x9gknd 9993 5 confirmed confirm VBN cord-010119-t1x9gknd 9993 6 that that IN cord-010119-t1x9gknd 9993 7 ZIKV ZIKV NNP cord-010119-t1x9gknd 9993 8 can can MD cord-010119-t1x9gknd 9993 9 be be VB cord-010119-t1x9gknd 9993 10 transmitted transmit VBN cord-010119-t1x9gknd 9993 11 by by IN cord-010119-t1x9gknd 9993 12 transfusion transfusion NN cord-010119-t1x9gknd 9993 13 . . . cord-010119-t1x9gknd 9994 1 It -PRON- PRP cord-010119-t1x9gknd 9994 2 has have VBZ cord-010119-t1x9gknd 9994 3 been be VBN cord-010119-t1x9gknd 9994 4 shown show VBN cord-010119-t1x9gknd 9994 5 that that IN cord-010119-t1x9gknd 9994 6 among among IN cord-010119-t1x9gknd 9994 7 blood blood NN cord-010119-t1x9gknd 9994 8 donors donor NNS cord-010119-t1x9gknd 9994 9 , , , cord-010119-t1x9gknd 9994 10 73.8 73.8 CD cord-010119-t1x9gknd 9994 11 % % NN cord-010119-t1x9gknd 9994 12 of of IN cord-010119-t1x9gknd 9994 13 the the DT cord-010119-t1x9gknd 9994 14 ZIKV ZIKV NNP cord-010119-t1x9gknd 9994 15 infections infection NNS cord-010119-t1x9gknd 9994 16 were be VBD cord-010119-t1x9gknd 9994 17 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 9994 18 and and CC cord-010119-t1x9gknd 9994 19 the the DT cord-010119-t1x9gknd 9994 20 ratio ratio NN cord-010119-t1x9gknd 9994 21 of of IN cord-010119-t1x9gknd 9994 22 symptomatic symptomatic JJ cord-010119-t1x9gknd 9994 23 to to IN cord-010119-t1x9gknd 9994 24 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 9994 25 patients patient NNS cord-010119-t1x9gknd 9994 26 observed observe VBN cord-010119-t1x9gknd 9994 27 in in IN cord-010119-t1x9gknd 9994 28 Micronesia Micronesia NNP cord-010119-t1x9gknd 9994 29 was be VBD cord-010119-t1x9gknd 9994 30 approximately approximately RB cord-010119-t1x9gknd 9994 31 1:5 1:5 CD cord-010119-t1x9gknd 9994 32 to to IN cord-010119-t1x9gknd 9994 33 1:6 1:6 CD cord-010119-t1x9gknd 9994 34 . . . cord-010119-t1x9gknd 9995 1 Thus thus RB cord-010119-t1x9gknd 9995 2 ZIKV ZIKV NNP cord-010119-t1x9gknd 9995 3 has have VBZ cord-010119-t1x9gknd 9995 4 raised raise VBN cord-010119-t1x9gknd 9995 5 a a DT cord-010119-t1x9gknd 9995 6 great great JJ cord-010119-t1x9gknd 9995 7 challenge challenge NN cord-010119-t1x9gknd 9995 8 to to IN cord-010119-t1x9gknd 9995 9 transfusion transfusion NN cord-010119-t1x9gknd 9995 10 safety safety NN cord-010119-t1x9gknd 9995 11 . . . cord-010119-t1x9gknd 9996 1 Measures measure NNS cord-010119-t1x9gknd 9996 2 should should MD cord-010119-t1x9gknd 9996 3 be be VB cord-010119-t1x9gknd 9996 4 taken take VBN cord-010119-t1x9gknd 9996 5 to to TO cord-010119-t1x9gknd 9996 6 prevent prevent VB cord-010119-t1x9gknd 9996 7 transfusion transfusion NN cord-010119-t1x9gknd 9996 8 - - HYPH cord-010119-t1x9gknd 9996 9 transmitted transmit VBN cord-010119-t1x9gknd 9996 10 ZIKV ZIKV NNP cord-010119-t1x9gknd 9996 11 , , , cord-010119-t1x9gknd 9996 12 including include VBG cord-010119-t1x9gknd 9996 13 temporary temporary JJ cord-010119-t1x9gknd 9996 14 deferral deferral NN cord-010119-t1x9gknd 9996 15 of of IN cord-010119-t1x9gknd 9996 16 blood blood NN cord-010119-t1x9gknd 9996 17 donors donor NNS cord-010119-t1x9gknd 9996 18 in in IN cord-010119-t1x9gknd 9996 19 epidemic epidemic NN cord-010119-t1x9gknd 9996 20 locations location NNS cord-010119-t1x9gknd 9996 21 , , , cord-010119-t1x9gknd 9996 22 donor donor NN cord-010119-t1x9gknd 9996 23 self self NN cord-010119-t1x9gknd 9996 24 - - HYPH cord-010119-t1x9gknd 9996 25 reporting reporting NN cord-010119-t1x9gknd 9996 26 of of IN cord-010119-t1x9gknd 9996 27 ZIKV ZIKV NNP cord-010119-t1x9gknd 9996 28 symptoms symptom NNS cord-010119-t1x9gknd 9996 29 after after IN cord-010119-t1x9gknd 9996 30 donation donation NN cord-010119-t1x9gknd 9996 31 with with IN cord-010119-t1x9gknd 9996 32 or or CC cord-010119-t1x9gknd 9996 33 without without IN cord-010119-t1x9gknd 9996 34 quarantine quarantine NN cord-010119-t1x9gknd 9996 35 of of IN cord-010119-t1x9gknd 9996 36 blood blood NN cord-010119-t1x9gknd 9996 37 components component NNS cord-010119-t1x9gknd 9996 38 , , , cord-010119-t1x9gknd 9996 39 supply supply NN cord-010119-t1x9gknd 9996 40 by by IN cord-010119-t1x9gknd 9996 41 blood blood NN cord-010119-t1x9gknd 9996 42 collected collect VBN cord-010119-t1x9gknd 9996 43 from from IN cord-010119-t1x9gknd 9996 44 non non JJ cord-010119-t1x9gknd 9996 45 - - JJ cord-010119-t1x9gknd 9996 46 endemic endemic JJ cord-010119-t1x9gknd 9996 47 areas area NNS cord-010119-t1x9gknd 9996 48 to to IN cord-010119-t1x9gknd 9996 49 epidemic epidemic NN cord-010119-t1x9gknd 9996 50 regions region NNS cord-010119-t1x9gknd 9996 51 , , , cord-010119-t1x9gknd 9996 52 NAT NAT NNP cord-010119-t1x9gknd 9996 53 of of IN cord-010119-t1x9gknd 9996 54 blood blood NN cord-010119-t1x9gknd 9996 55 donations donation NNS cord-010119-t1x9gknd 9996 56 , , , cord-010119-t1x9gknd 9996 57 and and CC cord-010119-t1x9gknd 9996 58 pathogen pathogen NN cord-010119-t1x9gknd 9996 59 inactivation inactivation NN cord-010119-t1x9gknd 9996 60 of of IN cord-010119-t1x9gknd 9996 61 blood blood NN cord-010119-t1x9gknd 9996 62 products product NNS cord-010119-t1x9gknd 9996 63 . . . cord-010119-t1x9gknd 9997 1 In in IN cord-010119-t1x9gknd 9997 2 this this DT cord-010119-t1x9gknd 9997 3 study study NN cord-010119-t1x9gknd 9997 4 , , , cord-010119-t1x9gknd 9997 5 we -PRON- PRP cord-010119-t1x9gknd 9997 6 evaluated evaluate VBD cord-010119-t1x9gknd 9997 7 ZIKV ZIKV NNP cord-010119-t1x9gknd 9997 8 inactivation inactivation NN cord-010119-t1x9gknd 9997 9 in in IN cord-010119-t1x9gknd 9997 10 plasma plasma NN cord-010119-t1x9gknd 9997 11 by by IN cord-010119-t1x9gknd 9997 12 using use VBG cord-010119-t1x9gknd 9997 13 methylene methylene NN cord-010119-t1x9gknd 9997 14 blue blue JJ cord-010119-t1x9gknd 9997 15 photochemical photochemical JJ cord-010119-t1x9gknd 9997 16 treatment treatment NN cord-010119-t1x9gknd 9997 17 ( ( -LRB- cord-010119-t1x9gknd 9997 18 MBPT MBPT NNP cord-010119-t1x9gknd 9997 19 ) ) -RRB- cord-010119-t1x9gknd 9997 20 . . . cord-010119-t1x9gknd 9998 1 Study Study NNP cord-010119-t1x9gknd 9998 2 Design Design NNP cord-010119-t1x9gknd 9998 3 / / SYM cord-010119-t1x9gknd 9998 4 Methods method NNS cord-010119-t1x9gknd 9998 5 : : : cord-010119-t1x9gknd 9999 1 Plasma plasma NN cord-010119-t1x9gknd 9999 2 units unit NNS cord-010119-t1x9gknd 9999 3 from from IN cord-010119-t1x9gknd 9999 4 randomly randomly RB cord-010119-t1x9gknd 9999 5 selected select VBN cord-010119-t1x9gknd 9999 6 healthy healthy JJ cord-010119-t1x9gknd 9999 7 donors donor NNS cord-010119-t1x9gknd 9999 8 were be VBD cord-010119-t1x9gknd 9999 9 collected collect VBN cord-010119-t1x9gknd 9999 10 and and CC cord-010119-t1x9gknd 9999 11 spiked spike VBN cord-010119-t1x9gknd 9999 12 with with IN cord-010119-t1x9gknd 9999 13 ZIKV ZIKV NNP cord-010119-t1x9gknd 9999 14 . . . cord-010119-t1x9gknd 10000 1 Samples sample NNS cord-010119-t1x9gknd 10000 2 were be VBD cord-010119-t1x9gknd 10000 3 added add VBN cord-010119-t1x9gknd 10000 4 by by IN cord-010119-t1x9gknd 10000 5 MB mb NN cord-010119-t1x9gknd 10000 6 at at IN cord-010119-t1x9gknd 10000 7 a a DT cord-010119-t1x9gknd 10000 8 final final JJ cord-010119-t1x9gknd 10000 9 concentration concentration NN cord-010119-t1x9gknd 10000 10 of of IN cord-010119-t1x9gknd 10000 11 1lM 1lm CD cord-010119-t1x9gknd 10000 12 and and CC cord-010119-t1x9gknd 10000 13 assayed assay VBN cord-010119-t1x9gknd 10000 14 after after IN cord-010119-t1x9gknd 10000 15 illumination illumination NN cord-010119-t1x9gknd 10000 16 with with IN cord-010119-t1x9gknd 10000 17 visible visible JJ cord-010119-t1x9gknd 10000 18 light light NN cord-010119-t1x9gknd 10000 19 from from IN cord-010119-t1x9gknd 10000 20 both both DT cord-010119-t1x9gknd 10000 21 sides side NNS cord-010119-t1x9gknd 10000 22 for for IN cord-010119-t1x9gknd 10000 23 5 5 CD cord-010119-t1x9gknd 10000 24 , , , cord-010119-t1x9gknd 10000 25 15 15 CD cord-010119-t1x9gknd 10000 26 , , , cord-010119-t1x9gknd 10000 27 and and CC cord-010119-t1x9gknd 10000 28 30min 30min NN cord-010119-t1x9gknd 10000 29 . . . cord-010119-t1x9gknd 10001 1 Viral viral JJ cord-010119-t1x9gknd 10001 2 infectivity infectivity NN cord-010119-t1x9gknd 10001 3 and and CC cord-010119-t1x9gknd 10001 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 10001 5 RNA RNA NNP cord-010119-t1x9gknd 10001 6 loads load NNS cord-010119-t1x9gknd 10001 7 ( ( -LRB- cord-010119-t1x9gknd 10001 8 reverse reverse VB cord-010119-t1x9gknd 10001 9 transcription transcription NN cord-010119-t1x9gknd 10001 10 PCR PCR NNP cord-010119-t1x9gknd 10001 11 ) ) -RRB- cord-010119-t1x9gknd 10001 12 were be VBD cord-010119-t1x9gknd 10001 13 measured measure VBN cord-010119-t1x9gknd 10001 14 in in IN cord-010119-t1x9gknd 10001 15 spiked spiked JJ cord-010119-t1x9gknd 10001 16 plasma plasma NN cord-010119-t1x9gknd 10001 17 before before RB cord-010119-t1x9gknd 10001 18 and and CC cord-010119-t1x9gknd 10001 19 after after IN cord-010119-t1x9gknd 10001 20 MBPT MBPT NNP cord-010119-t1x9gknd 10001 21 and and CC cord-010119-t1x9gknd 10001 22 confirmed confirm VBD cord-010119-t1x9gknd 10001 23 using use VBG cord-010119-t1x9gknd 10001 24 repetitive repetitive JJ cord-010119-t1x9gknd 10001 25 passages passage NNS cord-010119-t1x9gknd 10001 26 in in IN cord-010119-t1x9gknd 10001 27 cell cell NN cord-010119-t1x9gknd 10001 28 culture culture NN cord-010119-t1x9gknd 10001 29 . . . cord-010119-t1x9gknd 10002 1 Control control NN cord-010119-t1x9gknd 10002 2 was be VBD cord-010119-t1x9gknd 10002 3 ZIKV ZIKV NNP cord-010119-t1x9gknd 10002 4 spiked spiked JJ cord-010119-t1x9gknd 10002 5 plasma plasma NN cord-010119-t1x9gknd 10002 6 without without IN cord-010119-t1x9gknd 10002 7 photochemical photochemical JJ cord-010119-t1x9gknd 10002 8 treatment treatment NN cord-010119-t1x9gknd 10002 9 . . . cord-010119-t1x9gknd 10003 1 Results result NNS cord-010119-t1x9gknd 10003 2 / / SYM cord-010119-t1x9gknd 10003 3 Findings finding NNS cord-010119-t1x9gknd 10003 4 : : : cord-010119-t1x9gknd 10003 5 ZIKV ZIKV NNP cord-010119-t1x9gknd 10003 6 titer titer NN cord-010119-t1x9gknd 10003 7 of of IN cord-010119-t1x9gknd 10003 8 control control NN cord-010119-t1x9gknd 10003 9 sample sample NN cord-010119-t1x9gknd 10003 10 was be VBD cord-010119-t1x9gknd 10003 11 4.5 4.5 CD cord-010119-t1x9gknd 10003 12 log log NN cord-010119-t1x9gknd 10003 13 50 50 CD cord-010119-t1x9gknd 10003 14 % % NN cord-010119-t1x9gknd 10003 15 tissue tissue NN cord-010119-t1x9gknd 10003 16 culture culture NN cord-010119-t1x9gknd 10003 17 infectious infectious JJ cord-010119-t1x9gknd 10003 18 dose dose NN cord-010119-t1x9gknd 10003 19 ( ( -LRB- cord-010119-t1x9gknd 10003 20 TCID TCID NNP cord-010119-t1x9gknd 10003 21 50 50 CD cord-010119-t1x9gknd 10003 22 ) ) -RRB- cord-010119-t1x9gknd 10003 23 /mL. /mL. . cord-010119-t1x9gknd 10004 1 No no DT cord-010119-t1x9gknd 10004 2 viral viral JJ cord-010119-t1x9gknd 10004 3 infectivity infectivity NN cord-010119-t1x9gknd 10004 4 was be VBD cord-010119-t1x9gknd 10004 5 detected detect VBN cord-010119-t1x9gknd 10004 6 after after IN cord-010119-t1x9gknd 10004 7 MB mb NN cord-010119-t1x9gknd 10004 8 photochemical photochemical JJ cord-010119-t1x9gknd 10004 9 inactivation inactivation NN cord-010119-t1x9gknd 10004 10 treatment treatment NN cord-010119-t1x9gknd 10004 11 for for IN cord-010119-t1x9gknd 10004 12 5min 5min CD cord-010119-t1x9gknd 10004 13 , , , cord-010119-t1x9gknd 10004 14 15min 15min NN cord-010119-t1x9gknd 10004 15 or or CC cord-010119-t1x9gknd 10004 16 30min 30min NN cord-010119-t1x9gknd 10004 17 and and CC cord-010119-t1x9gknd 10004 18 the the DT cord-010119-t1x9gknd 10004 19 losses loss NNS cord-010119-t1x9gknd 10004 20 of of IN cord-010119-t1x9gknd 10004 21 the the DT cord-010119-t1x9gknd 10004 22 infectivity infectivity NN cord-010119-t1x9gknd 10004 23 were be VBD cord-010119-t1x9gknd 10004 24 further further RB cord-010119-t1x9gknd 10004 25 demonstrated demonstrate VBN cord-010119-t1x9gknd 10004 26 by by IN cord-010119-t1x9gknd 10004 27 3 3 CD cord-010119-t1x9gknd 10004 28 repetitive repetitive JJ cord-010119-t1x9gknd 10004 29 passages passage NNS cord-010119-t1x9gknd 10004 30 of of IN cord-010119-t1x9gknd 10004 31 cell cell NN cord-010119-t1x9gknd 10004 32 culture culture NN cord-010119-t1x9gknd 10004 33 . . . cord-010119-t1x9gknd 10005 1 Meanwhile meanwhile RB cord-010119-t1x9gknd 10005 2 , , , cord-010119-t1x9gknd 10005 3 ZIKV ZIKV NNP cord-010119-t1x9gknd 10005 4 RNA RNA NNP cord-010119-t1x9gknd 10005 5 loads load NNS cord-010119-t1x9gknd 10005 6 decreased decrease VBD cord-010119-t1x9gknd 10005 7 significantly significantly RB cord-010119-t1x9gknd 10005 8 during during IN cord-010119-t1x9gknd 10005 9 the the DT cord-010119-t1x9gknd 10005 10 initial initial JJ cord-010119-t1x9gknd 10005 11 5min 5min NN cord-010119-t1x9gknd 10005 12 of of IN cord-010119-t1x9gknd 10005 13 treatment treatment NN cord-010119-t1x9gknd 10005 14 whereby whereby WRB cord-010119-t1x9gknd 10005 15 Ct ct NN cord-010119-t1x9gknd 10005 16 - - HYPH cord-010119-t1x9gknd 10005 17 value value NN cord-010119-t1x9gknd 10005 18 jumped jump VBD cord-010119-t1x9gknd 10005 19 from from IN cord-010119-t1x9gknd 10005 20 18.25 18.25 CD cord-010119-t1x9gknd 10005 21 ( ( -LRB- cord-010119-t1x9gknd 10005 22 control control NN cord-010119-t1x9gknd 10005 23 ) ) -RRB- cord-010119-t1x9gknd 10005 24 to to IN cord-010119-t1x9gknd 10005 25 25.50 25.50 CD cord-010119-t1x9gknd 10005 26 ( ( -LRB- cord-010119-t1x9gknd 10005 27 MBPT MBPT NNP cord-010119-t1x9gknd 10005 28 for for IN cord-010119-t1x9gknd 10005 29 5min 5min CD cord-010119-t1x9gknd 10005 30 ) ) -RRB- cord-010119-t1x9gknd 10006 1 ( ( -LRB- cord-010119-t1x9gknd 10006 2 Table table NN cord-010119-t1x9gknd 10006 3 1 1 CD cord-010119-t1x9gknd 10006 4 ) ) -RRB- cord-010119-t1x9gknd 10006 5 . . . cord-010119-t1x9gknd 10007 1 Conclusion conclusion NN cord-010119-t1x9gknd 10007 2 : : : cord-010119-t1x9gknd 10008 1 It -PRON- PRP cord-010119-t1x9gknd 10008 2 showed show VBD cord-010119-t1x9gknd 10008 3 that that IN cord-010119-t1x9gknd 10008 4 MB mb NN cord-010119-t1x9gknd 10008 5 photochemical photochemical JJ cord-010119-t1x9gknd 10008 6 treatment treatment NN cord-010119-t1x9gknd 10008 7 could could MD cord-010119-t1x9gknd 10008 8 effectively effectively RB cord-010119-t1x9gknd 10008 9 inactivate inactivate VB cord-010119-t1x9gknd 10008 10 ZIKV ZIKV NNP cord-010119-t1x9gknd 10008 11 in in IN cord-010119-t1x9gknd 10008 12 plasma plasma NN cord-010119-t1x9gknd 10008 13 . . . cord-010119-t1x9gknd 10009 1 RNA RNA NNP cord-010119-t1x9gknd 10009 2 lesions lesion NNS cord-010119-t1x9gknd 10009 3 were be VBD cord-010119-t1x9gknd 10009 4 induced induce VBN cord-010119-t1x9gknd 10009 5 during during IN cord-010119-t1x9gknd 10009 6 MBPT MBPT NNP cord-010119-t1x9gknd 10009 7 process process NN cord-010119-t1x9gknd 10009 8 so so IN cord-010119-t1x9gknd 10009 9 that that IN cord-010119-t1x9gknd 10009 10 nucleic nucleic JJ cord-010119-t1x9gknd 10009 11 acid acid NN cord-010119-t1x9gknd 10009 12 reverse reverse NN cord-010119-t1x9gknd 10009 13 transcription transcription NN cord-010119-t1x9gknd 10009 14 and and CC cord-010119-t1x9gknd 10009 15 amplification amplification NN cord-010119-t1x9gknd 10009 16 were be VBD cord-010119-t1x9gknd 10009 17 inhibited inhibit VBN cord-010119-t1x9gknd 10009 18 . . . cord-010119-t1x9gknd 10010 1 MBPT MBPT NNP cord-010119-t1x9gknd 10010 2 is be VBZ cord-010119-t1x9gknd 10010 3 proved prove VBN cord-010119-t1x9gknd 10010 4 to to TO cord-010119-t1x9gknd 10010 5 be be VB cord-010119-t1x9gknd 10010 6 an an DT cord-010119-t1x9gknd 10010 7 efficient efficient JJ cord-010119-t1x9gknd 10010 8 method method NN cord-010119-t1x9gknd 10010 9 to to TO cord-010119-t1x9gknd 10010 10 prevent prevent VB cord-010119-t1x9gknd 10010 11 plasma plasma NN cord-010119-t1x9gknd 10010 12 transfusiontransmitted transfusiontransmitte VBN cord-010119-t1x9gknd 10010 13 ZIKV ZIKV NNP cord-010119-t1x9gknd 10010 14 infections infection NNS cord-010119-t1x9gknd 10010 15 . . . cord-010119-t1x9gknd 10011 1 Gilles Gilles NNP cord-010119-t1x9gknd 10011 2 Delage Delage NNP cord-010119-t1x9gknd 10011 3 * * NFP cord-010119-t1x9gknd 10011 4 1 1 CD cord-010119-t1x9gknd 10011 5 , , , cord-010119-t1x9gknd 10011 6 Margaret Margaret NNP cord-010119-t1x9gknd 10011 7 Fearon Fearon NNP cord-010119-t1x9gknd 10011 8 2 2 CD cord-010119-t1x9gknd 10011 9 , , , cord-010119-t1x9gknd 10011 10 Susan Susan NNP cord-010119-t1x9gknd 10011 11 L L NNP cord-010119-t1x9gknd 10011 12 Stramer Stramer NNP cord-010119-t1x9gknd 10011 13 3 3 CD cord-010119-t1x9gknd 10011 14 , , , cord-010119-t1x9gknd 10011 15 Megan Megan NNP cord-010119-t1x9gknd 10011 16 L L NNP cord-010119-t1x9gknd 10011 17 Nguyen Nguyen NNP cord-010119-t1x9gknd 10011 18 3 3 CD cord-010119-t1x9gknd 10011 19 , , , cord-010119-t1x9gknd 10011 20 France France NNP cord-010119-t1x9gknd 10011 21 Bernier Bernier NNP cord-010119-t1x9gknd 10011 22 1 1 CD cord-010119-t1x9gknd 10011 23 , , , cord-010119-t1x9gknd 10011 24 Sheila Sheila NNP cord-010119-t1x9gknd 10011 25 O'Brien O'Brien NNP cord-010119-t1x9gknd 10011 26 2 2 CD cord-010119-t1x9gknd 10011 27 , , , cord-010119-t1x9gknd 10011 28 Vito Vito NNP cord-010119-t1x9gknd 10011 29 Scalia Scalia NNP cord-010119-t1x9gknd 10011 30 2 2 CD cord-010119-t1x9gknd 10011 31 , , , cord-010119-t1x9gknd 10011 32 Sakina Sakina NNP cord-010119-t1x9gknd 10011 33 Smith Smith NNP cord-010119-t1x9gknd 10011 34 3 3 CD cord-010119-t1x9gknd 10011 35 , , , cord-010119-t1x9gknd 10011 36 Yves Yves NNP cord-010119-t1x9gknd 10011 37 Gr Gr NNP cord-010119-t1x9gknd 10011 38 egoire egoire NN cord-010119-t1x9gknd 10011 39 1 1 CD cord-010119-t1x9gknd 10011 40 and and CC cord-010119-t1x9gknd 10011 41 Boris Boris NNP cord-010119-t1x9gknd 10011 42 Hogema Hogema NNP cord-010119-t1x9gknd 10011 43 4 4 CD cord-010119-t1x9gknd 10011 44 . . . cord-010119-t1x9gknd 10012 1 1 1 LS cord-010119-t1x9gknd 10013 1 H H NNP cord-010119-t1x9gknd 10013 2 ema ema NNP cord-010119-t1x9gknd 10013 3 - - HYPH cord-010119-t1x9gknd 10013 4 Qu Qu NNP cord-010119-t1x9gknd 10014 1 ebec ebec NNP cord-010119-t1x9gknd 10014 2 , , , cord-010119-t1x9gknd 10014 3 2 2 CD cord-010119-t1x9gknd 10014 4 Canadian Canadian NNP cord-010119-t1x9gknd 10014 5 Blood Blood NNP cord-010119-t1x9gknd 10014 6 Services Services NNPS cord-010119-t1x9gknd 10014 7 , , , cord-010119-t1x9gknd 10014 8 3 3 CD cord-010119-t1x9gknd 10014 9 American American NNP cord-010119-t1x9gknd 10014 10 Red Red NNP cord-010119-t1x9gknd 10014 11 Cross Cross NNP cord-010119-t1x9gknd 10014 12 , , , cord-010119-t1x9gknd 10014 13 4 4 CD cord-010119-t1x9gknd 10014 14 Sanquin Sanquin NNP cord-010119-t1x9gknd 10014 15 Background Background NNP cord-010119-t1x9gknd 10014 16 / / SYM cord-010119-t1x9gknd 10014 17 Case Case NNP cord-010119-t1x9gknd 10014 18 Studies Studies NNPS cord-010119-t1x9gknd 10014 19 : : : cord-010119-t1x9gknd 10014 20 Hepatitis hepatitis NN cord-010119-t1x9gknd 10014 21 E e NN cord-010119-t1x9gknd 10014 22 virus virus NN cord-010119-t1x9gknd 10014 23 ( ( -LRB- cord-010119-t1x9gknd 10014 24 HEV HEV NNP cord-010119-t1x9gknd 10014 25 ) ) -RRB- cord-010119-t1x9gknd 10014 26 is be VBZ cord-010119-t1x9gknd 10014 27 known know VBN cord-010119-t1x9gknd 10014 28 to to TO cord-010119-t1x9gknd 10014 29 be be VB cord-010119-t1x9gknd 10014 30 transfusion transfusion NN cord-010119-t1x9gknd 10014 31 - - HYPH cord-010119-t1x9gknd 10014 32 transmissible transmissible JJ cord-010119-t1x9gknd 10014 33 . . . cord-010119-t1x9gknd 10015 1 As as IN cord-010119-t1x9gknd 10015 2 part part NN cord-010119-t1x9gknd 10015 3 of of IN cord-010119-t1x9gknd 10015 4 the the DT cord-010119-t1x9gknd 10015 5 risk risk NN cord-010119-t1x9gknd 10015 6 assessment assessment NN cord-010119-t1x9gknd 10015 7 for for IN cord-010119-t1x9gknd 10015 8 this this DT cord-010119-t1x9gknd 10015 9 infection infection NN cord-010119-t1x9gknd 10015 10 , , , cord-010119-t1x9gknd 10015 11 a a DT cord-010119-t1x9gknd 10015 12 study study NN cord-010119-t1x9gknd 10015 13 was be VBD cord-010119-t1x9gknd 10015 14 carried carry VBN cord-010119-t1x9gknd 10015 15 out out RP cord-010119-t1x9gknd 10015 16 in in IN cord-010119-t1x9gknd 10015 17 14,000 14,000 CD cord-010119-t1x9gknd 10015 18 Canadian canadian JJ cord-010119-t1x9gknd 10015 19 blood blood NN cord-010119-t1x9gknd 10015 20 donors donor NNS cord-010119-t1x9gknd 10015 21 in in IN cord-010119-t1x9gknd 10015 22 2013 2013 CD cord-010119-t1x9gknd 10015 23 . . . cord-010119-t1x9gknd 10016 1 In in IN cord-010119-t1x9gknd 10016 2 a a DT cord-010119-t1x9gknd 10016 3 subset subset NN cord-010119-t1x9gknd 10016 4 of of IN cord-010119-t1x9gknd 10016 5 4,000 4,000 CD cord-010119-t1x9gknd 10016 6 donor donor NN cord-010119-t1x9gknd 10016 7 samples sample NNS cord-010119-t1x9gknd 10016 8 the the DT cord-010119-t1x9gknd 10016 9 seroprevalence seroprevalence NN cord-010119-t1x9gknd 10016 10 was be VBD cord-010119-t1x9gknd 10016 11 5.9 5.9 CD cord-010119-t1x9gknd 10016 12 % % NN cord-010119-t1x9gknd 10016 13 . . . cord-010119-t1x9gknd 10017 1 However however RB cord-010119-t1x9gknd 10017 2 , , , cord-010119-t1x9gknd 10017 3 no no DT cord-010119-t1x9gknd 10017 4 donor donor NN cord-010119-t1x9gknd 10017 5 samples sample NNS cord-010119-t1x9gknd 10017 6 were be VBD cord-010119-t1x9gknd 10017 7 positive positive JJ cord-010119-t1x9gknd 10017 8 for for IN cord-010119-t1x9gknd 10017 9 HEV HEV NNP cord-010119-t1x9gknd 10017 10 by by IN cord-010119-t1x9gknd 10017 11 an an DT cord-010119-t1x9gknd 10017 12 in in IN cord-010119-t1x9gknd 10017 13 - - HYPH cord-010119-t1x9gknd 10017 14 house house NN cord-010119-t1x9gknd 10017 15 nucleic nucleic JJ cord-010119-t1x9gknd 10017 16 acid acid NN cord-010119-t1x9gknd 10017 17 test test NN cord-010119-t1x9gknd 10017 18 ( ( -LRB- cord-010119-t1x9gknd 10017 19 HEV HEV NNP cord-010119-t1x9gknd 10017 20 - - HYPH cord-010119-t1x9gknd 10017 21 NAT NAT NNP cord-010119-t1x9gknd 10017 22 ) ) -RRB- cord-010119-t1x9gknd 10017 23 . . . cord-010119-t1x9gknd 10018 1 Since since IN cord-010119-t1x9gknd 10018 2 that that DT cord-010119-t1x9gknd 10018 3 study study NN cord-010119-t1x9gknd 10018 4 suggested suggest VBD cord-010119-t1x9gknd 10018 5 exposure exposure NN cord-010119-t1x9gknd 10018 6 to to IN cord-010119-t1x9gknd 10018 7 HEV hev VB cord-010119-t1x9gknd 10018 8 in in IN cord-010119-t1x9gknd 10018 9 Canada Canada NNP cord-010119-t1x9gknd 10018 10 but but CC cord-010119-t1x9gknd 10018 11 used use VBD cord-010119-t1x9gknd 10018 12 an an DT cord-010119-t1x9gknd 10018 13 HEV HEV NNP cord-010119-t1x9gknd 10018 14 - - HYPH cord-010119-t1x9gknd 10018 15 NAT NAT NNP cord-010119-t1x9gknd 10018 16 with with IN cord-010119-t1x9gknd 10018 17 a a DT cord-010119-t1x9gknd 10018 18 limit limit NN cord-010119-t1x9gknd 10018 19 of of IN cord-010119-t1x9gknd 10018 20 detection detection NN cord-010119-t1x9gknd 10018 21 of of IN cord-010119-t1x9gknd 10018 22 250 250 CD cord-010119-t1x9gknd 10018 23 IU IU NNP cord-010119-t1x9gknd 10018 24 / / SYM cord-010119-t1x9gknd 10018 25 mL mL NNP cord-010119-t1x9gknd 10018 26 , , , cord-010119-t1x9gknd 10018 27 a a DT cord-010119-t1x9gknd 10018 28 larger large JJR cord-010119-t1x9gknd 10018 29 study study NN cord-010119-t1x9gknd 10018 30 was be VBD cord-010119-t1x9gknd 10018 31 performed perform VBN cord-010119-t1x9gknd 10018 32 using use VBG cord-010119-t1x9gknd 10018 33 a a DT cord-010119-t1x9gknd 10018 34 more more RBR cord-010119-t1x9gknd 10018 35 sensitive sensitive JJ cord-010119-t1x9gknd 10018 36 HEV HEV NNP cord-010119-t1x9gknd 10018 37 - - HYPH cord-010119-t1x9gknd 10018 38 NAT NAT NNP cord-010119-t1x9gknd 10018 39 assay assay NN cord-010119-t1x9gknd 10018 40 . . . cord-010119-t1x9gknd 10019 1 Study Study NNP cord-010119-t1x9gknd 10019 2 Design Design NNP cord-010119-t1x9gknd 10019 3 / / SYM cord-010119-t1x9gknd 10019 4 Method method NN cord-010119-t1x9gknd 10019 5 : : : cord-010119-t1x9gknd 10020 1 Donors donor NNS cord-010119-t1x9gknd 10020 2 were be VBD cord-010119-t1x9gknd 10020 3 informed inform VBN cord-010119-t1x9gknd 10020 4 about about IN cord-010119-t1x9gknd 10020 5 the the DT cord-010119-t1x9gknd 10020 6 study study NN cord-010119-t1x9gknd 10020 7 in in IN cord-010119-t1x9gknd 10020 8 the the DT cord-010119-t1x9gknd 10020 9 predonation predonation NN cord-010119-t1x9gknd 10020 10 reading read VBG cord-010119-t1x9gknd 10020 11 materials material NNS cord-010119-t1x9gknd 10020 12 . . . cord-010119-t1x9gknd 10021 1 Linked link VBN cord-010119-t1x9gknd 10021 2 samples sample NNS cord-010119-t1x9gknd 10021 3 from from IN cord-010119-t1x9gknd 10021 4 approximately approximately RB cord-010119-t1x9gknd 10021 5 50,000 50,000 CD cord-010119-t1x9gknd 10021 6 Canadian canadian JJ cord-010119-t1x9gknd 10021 7 whole whole JJ cord-010119-t1x9gknd 10021 8 blood blood NN cord-010119-t1x9gknd 10021 9 donors donor NNS cord-010119-t1x9gknd 10021 10 including include VBG cord-010119-t1x9gknd 10021 11 30,000 30,000 CD cord-010119-t1x9gknd 10021 12 from from IN cord-010119-t1x9gknd 10021 13 Canadian Canadian NNP cord-010119-t1x9gknd 10021 14 Blood Blood NNP cord-010119-t1x9gknd 10021 15 Services Services NNPS cord-010119-t1x9gknd 10021 16 ( ( -LRB- cord-010119-t1x9gknd 10021 17 CBS CBS NNP cord-010119-t1x9gknd 10021 18 ) ) -RRB- cord-010119-t1x9gknd 10021 19 and and CC cord-010119-t1x9gknd 10021 20 20,000 20,000 CD cord-010119-t1x9gknd 10021 21 from from IN cord-010119-t1x9gknd 10021 22 H H NNP cord-010119-t1x9gknd 10021 23 ema ema NNP cord-010119-t1x9gknd 10021 24 - - HYPH cord-010119-t1x9gknd 10021 25 Qu Qu NNP cord-010119-t1x9gknd 10021 26 ebec ebec NNP cord-010119-t1x9gknd 10021 27 ( ( -LRB- cord-010119-t1x9gknd 10021 28 HQ HQ NNP cord-010119-t1x9gknd 10021 29 ) ) -RRB- cord-010119-t1x9gknd 10021 30 were be VBD cord-010119-t1x9gknd 10021 31 collected collect VBN cord-010119-t1x9gknd 10021 32 . . . cord-010119-t1x9gknd 10022 1 Clinics clinic NNS cord-010119-t1x9gknd 10022 2 were be VBD cord-010119-t1x9gknd 10022 3 selected select VBN cord-010119-t1x9gknd 10022 4 to to TO cord-010119-t1x9gknd 10022 5 ensure ensure VB cord-010119-t1x9gknd 10022 6 representative representative JJ cord-010119-t1x9gknd 10022 7 sampling sampling NN cord-010119-t1x9gknd 10022 8 of of IN cord-010119-t1x9gknd 10022 9 the the DT cord-010119-t1x9gknd 10022 10 donor donor NN cord-010119-t1x9gknd 10022 11 population population NN cord-010119-t1x9gknd 10022 12 . . . cord-010119-t1x9gknd 10023 1 All all DT cord-010119-t1x9gknd 10023 2 199A 199a CD cord-010119-t1x9gknd 10023 3 TRANSFUSION transfusion NN cord-010119-t1x9gknd 10023 4 2017 2017 CD cord-010119-t1x9gknd 10023 5 Vol Vol NNP cord-010119-t1x9gknd 10023 6 . . . cord-010119-t1x9gknd 10024 1 57 57 CD cord-010119-t1x9gknd 10025 1 Supplement supplement NN cord-010119-t1x9gknd 10025 2 S3 S3 NNP cord-010119-t1x9gknd 10025 3 donations donation NNS cord-010119-t1x9gknd 10025 4 with with IN cord-010119-t1x9gknd 10025 5 available available JJ cord-010119-t1x9gknd 10025 6 plasma plasma NN cord-010119-t1x9gknd 10025 7 samples sample NNS cord-010119-t1x9gknd 10025 8 were be VBD cord-010119-t1x9gknd 10025 9 tested test VBN cord-010119-t1x9gknd 10025 10 by by IN cord-010119-t1x9gknd 10025 11 individual individual JJ cord-010119-t1x9gknd 10025 12 donation donation NN cord-010119-t1x9gknd 10025 13 NAT NAT NNP cord-010119-t1x9gknd 10025 14 at at IN cord-010119-t1x9gknd 10025 15 the the DT cord-010119-t1x9gknd 10025 16 American American NNP cord-010119-t1x9gknd 10025 17 Red Red NNP cord-010119-t1x9gknd 10025 18 Cross Cross NNP cord-010119-t1x9gknd 10025 19 laboratory laboratory NN cord-010119-t1x9gknd 10025 20 in in IN cord-010119-t1x9gknd 10025 21 Gaithersburg Gaithersburg NNP cord-010119-t1x9gknd 10025 22 , , , cord-010119-t1x9gknd 10025 23 MD MD NNP cord-010119-t1x9gknd 10025 24 , , , cord-010119-t1x9gknd 10025 25 using use VBG cord-010119-t1x9gknd 10025 26 the the DT cord-010119-t1x9gknd 10025 27 cobas cobas NN cord-010119-t1x9gknd 10025 28 V v NN cord-010119-t1x9gknd 10025 29 R r NN cord-010119-t1x9gknd 10025 30 HEV hev NN cord-010119-t1x9gknd 10025 31 test test NN cord-010119-t1x9gknd 10025 32 ( ( -LRB- cord-010119-t1x9gknd 10025 33 95 95 CD cord-010119-t1x9gknd 10025 34 % % NN cord-010119-t1x9gknd 10025 35 LOD lod NN cord-010119-t1x9gknd 10025 36 18.6 18.6 CD cord-010119-t1x9gknd 10025 37 IU IU NNP cord-010119-t1x9gknd 10025 38 / / SYM cord-010119-t1x9gknd 10025 39 mL mL NNP cord-010119-t1x9gknd 10025 40 , , , cord-010119-t1x9gknd 10025 41 95 95 CD cord-010119-t1x9gknd 10025 42 % % NN cord-010119-t1x9gknd 10025 43 CI CI NNP cord-010119-t1x9gknd 10025 44 15.9 15.9 CD cord-010119-t1x9gknd 10025 45 - - HYPH cord-010119-t1x9gknd 10025 46 25.6 25.6 CD cord-010119-t1x9gknd 10025 47 ) ) -RRB- cord-010119-t1x9gknd 10025 48 for for IN cord-010119-t1x9gknd 10025 49 use use NN cord-010119-t1x9gknd 10025 50 on on IN cord-010119-t1x9gknd 10025 51 the the DT cord-010119-t1x9gknd 10025 52 cobas cobas NN cord-010119-t1x9gknd 10025 53 V v NN cord-010119-t1x9gknd 10025 54 R r NN cord-010119-t1x9gknd 10025 55 6800/8800 6800/8800 CD cord-010119-t1x9gknd 10025 56 System system NN cord-010119-t1x9gknd 10025 57 . . . cord-010119-t1x9gknd 10026 1 This this DT cord-010119-t1x9gknd 10026 2 test test NN cord-010119-t1x9gknd 10026 3 is be VBZ cord-010119-t1x9gknd 10026 4 not not RB cord-010119-t1x9gknd 10026 5 currently currently RB cord-010119-t1x9gknd 10026 6 approved approve VBN cord-010119-t1x9gknd 10026 7 in in IN cord-010119-t1x9gknd 10026 8 Canada Canada NNP cord-010119-t1x9gknd 10026 9 or or CC cord-010119-t1x9gknd 10026 10 the the DT cord-010119-t1x9gknd 10026 11 USA USA NNP cord-010119-t1x9gknd 10026 12 , , , cord-010119-t1x9gknd 10026 13 but but CC cord-010119-t1x9gknd 10026 14 is be VBZ cord-010119-t1x9gknd 10026 15 available available JJ cord-010119-t1x9gknd 10026 16 as as IN cord-010119-t1x9gknd 10026 17 a a DT cord-010119-t1x9gknd 10026 18 CE CE NNP cord-010119-t1x9gknd 10026 19 marked mark VBN cord-010119-t1x9gknd 10026 20 test test NN cord-010119-t1x9gknd 10026 21 . . . cord-010119-t1x9gknd 10027 1 All all DT cord-010119-t1x9gknd 10027 2 NAT NAT NNP cord-010119-t1x9gknd 10027 3 - - HYPH cord-010119-t1x9gknd 10027 4 reactive reactive JJ cord-010119-t1x9gknd 10027 5 donors donor NNS cord-010119-t1x9gknd 10027 6 are be VBP cord-010119-t1x9gknd 10027 7 questioned question VBN cord-010119-t1x9gknd 10027 8 concerning concern VBG cord-010119-t1x9gknd 10027 9 risk risk NN cord-010119-t1x9gknd 10027 10 factors factor NNS cord-010119-t1x9gknd 10027 11 for for IN cord-010119-t1x9gknd 10027 12 recent recent JJ cord-010119-t1x9gknd 10027 13 HEV hev NN cord-010119-t1x9gknd 10027 14 infection infection NN cord-010119-t1x9gknd 10027 15 ( ( -LRB- cord-010119-t1x9gknd 10027 16 travel travel NN cord-010119-t1x9gknd 10027 17 , , , cord-010119-t1x9gknd 10027 18 animal animal NN cord-010119-t1x9gknd 10027 19 contact contact NN cord-010119-t1x9gknd 10027 20 , , , cord-010119-t1x9gknd 10027 21 food food NN cord-010119-t1x9gknd 10027 22 and and CC cord-010119-t1x9gknd 10027 23 water water NN cord-010119-t1x9gknd 10027 24 exposure exposure NN cord-010119-t1x9gknd 10027 25 ) ) -RRB- cord-010119-t1x9gknd 10027 26 , , , cord-010119-t1x9gknd 10027 27 undergo undergo VB cord-010119-t1x9gknd 10027 28 confirmatory confirmatory JJ cord-010119-t1x9gknd 10027 29 testing testing NN cord-010119-t1x9gknd 10027 30 ( ( -LRB- cord-010119-t1x9gknd 10027 31 alternate alternate JJ cord-010119-t1x9gknd 10027 32 NAT NAT NNP cord-010119-t1x9gknd 10027 33 , , , cord-010119-t1x9gknd 10027 34 viral viral JJ cord-010119-t1x9gknd 10027 35 load load NN cord-010119-t1x9gknd 10027 36 , , , cord-010119-t1x9gknd 10027 37 genotyping genotyping NN cord-010119-t1x9gknd 10027 38 and and CC cord-010119-t1x9gknd 10027 39 IgM IgM NNP cord-010119-t1x9gknd 10027 40 / / SYM cord-010119-t1x9gknd 10027 41 IgG IgG NNP cord-010119-t1x9gknd 10027 42 serology serology NNP cord-010119-t1x9gknd 10027 43 ) ) -RRB- cord-010119-t1x9gknd 10027 44 , , , cord-010119-t1x9gknd 10027 45 are be VBP cord-010119-t1x9gknd 10027 46 notified notify VBN cord-010119-t1x9gknd 10027 47 by by IN cord-010119-t1x9gknd 10027 48 letter letter NN cord-010119-t1x9gknd 10027 49 , , , cord-010119-t1x9gknd 10027 50 and and CC cord-010119-t1x9gknd 10027 51 deferred defer VBN cord-010119-t1x9gknd 10027 52 from from IN cord-010119-t1x9gknd 10027 53 donating donate VBG cord-010119-t1x9gknd 10027 54 for for IN cord-010119-t1x9gknd 10027 55 6 6 CD cord-010119-t1x9gknd 10027 56 months month NNS cord-010119-t1x9gknd 10027 57 ; ; : cord-010119-t1x9gknd 10027 58 in in IN cord-010119-t1x9gknd 10027 59 - - HYPH cord-010119-t1x9gknd 10027 60 date date NN cord-010119-t1x9gknd 10027 61 products product NNS cord-010119-t1x9gknd 10027 62 collected collect VBN cord-010119-t1x9gknd 10027 63 from from IN cord-010119-t1x9gknd 10027 64 the the DT cord-010119-t1x9gknd 10027 65 donor donor NN cord-010119-t1x9gknd 10027 66 , , , cord-010119-t1x9gknd 10027 67 and and CC cord-010119-t1x9gknd 10027 68 any any DT cord-010119-t1x9gknd 10027 69 frozen frozen JJ cord-010119-t1x9gknd 10027 70 red red JJ cord-010119-t1x9gknd 10027 71 blood blood NN cord-010119-t1x9gknd 10027 72 cells cell NNS cord-010119-t1x9gknd 10027 73 or or CC cord-010119-t1x9gknd 10027 74 plasma plasma NN cord-010119-t1x9gknd 10027 75 from from IN cord-010119-t1x9gknd 10027 76 the the DT cord-010119-t1x9gknd 10027 77 previous previous JJ cord-010119-t1x9gknd 10027 78 6 6 CD cord-010119-t1x9gknd 10027 79 months month NNS cord-010119-t1x9gknd 10027 80 are be VBP cord-010119-t1x9gknd 10027 81 destroyed destroy VBN cord-010119-t1x9gknd 10027 82 . . . cord-010119-t1x9gknd 10028 1 Recipients recipient NNS cord-010119-t1x9gknd 10028 2 will will MD cord-010119-t1x9gknd 10028 3 be be VB cord-010119-t1x9gknd 10028 4 traced trace VBN cord-010119-t1x9gknd 10028 5 in in IN cord-010119-t1x9gknd 10028 6 the the DT cord-010119-t1x9gknd 10028 7 event event NN cord-010119-t1x9gknd 10028 8 of of IN cord-010119-t1x9gknd 10028 9 any any DT cord-010119-t1x9gknd 10028 10 products product NNS cord-010119-t1x9gknd 10028 11 transfused transfuse VBN cord-010119-t1x9gknd 10028 12 in in IN cord-010119-t1x9gknd 10028 13 the the DT cord-010119-t1x9gknd 10028 14 previous previous JJ cord-010119-t1x9gknd 10028 15 6 6 CD cord-010119-t1x9gknd 10028 16 months month NNS cord-010119-t1x9gknd 10028 17 . . . cord-010119-t1x9gknd 10029 1 Results result NNS cord-010119-t1x9gknd 10029 2 / / SYM cord-010119-t1x9gknd 10029 3 Finding finding NN cord-010119-t1x9gknd 10029 4 : : : cord-010119-t1x9gknd 10030 1 As as IN cord-010119-t1x9gknd 10030 2 of of IN cord-010119-t1x9gknd 10030 3 April April NNP cord-010119-t1x9gknd 10030 4 10 10 CD cord-010119-t1x9gknd 10030 5 , , , cord-010119-t1x9gknd 10030 6 2017 2017 CD cord-010119-t1x9gknd 10030 7 , , , cord-010119-t1x9gknd 10030 8 9 9 CD cord-010119-t1x9gknd 10030 9 of of IN cord-010119-t1x9gknd 10030 10 39,834 39,834 CD cord-010119-t1x9gknd 10030 11 ( ( -LRB- cord-010119-t1x9gknd 10030 12 19,395 19,395 CD cord-010119-t1x9gknd 10030 13 CBS CBS NNP cord-010119-t1x9gknd 10030 14 , , , cord-010119-t1x9gknd 10030 15 20,439 20,439 CD cord-010119-t1x9gknd 10030 16 HQ HQ NNP cord-010119-t1x9gknd 10030 17 ) ) -RRB- cord-010119-t1x9gknd 10030 18 tested test VBD cord-010119-t1x9gknd 10030 19 samples sample NNS cord-010119-t1x9gknd 10030 20 with with IN cord-010119-t1x9gknd 10030 21 valid valid JJ cord-010119-t1x9gknd 10030 22 results result NNS cord-010119-t1x9gknd 10030 23 have have VBP cord-010119-t1x9gknd 10030 24 been be VBN cord-010119-t1x9gknd 10030 25 found find VBN cord-010119-t1x9gknd 10030 26 HEV HEV NNP cord-010119-t1x9gknd 10030 27 - - HYPH cord-010119-t1x9gknd 10030 28 NAT NAT NNP cord-010119-t1x9gknd 10030 29 reactive reactive JJ cord-010119-t1x9gknd 10030 30 : : : cord-010119-t1x9gknd 10030 31 8 8 CD cord-010119-t1x9gknd 10030 32 donors donor NNS cord-010119-t1x9gknd 10030 33 have have VBP cord-010119-t1x9gknd 10030 34 been be VBN cord-010119-t1x9gknd 10030 35 confirmed confirm VBN cord-010119-t1x9gknd 10030 36 by by IN cord-010119-t1x9gknd 10030 37 further further JJ cord-010119-t1x9gknd 10030 38 testing testing NN cord-010119-t1x9gknd 10030 39 to to IN cord-010119-t1x9gknd 10030 40 date date NN cord-010119-t1x9gknd 10030 41 . . . cord-010119-t1x9gknd 10031 1 Confirmation confirmation NN cord-010119-t1x9gknd 10031 2 is be VBZ cord-010119-t1x9gknd 10031 3 pending pende VBG cord-010119-t1x9gknd 10031 4 in in IN cord-010119-t1x9gknd 10031 5 1 1 CD cord-010119-t1x9gknd 10031 6 donor donor NN cord-010119-t1x9gknd 10031 7 . . . cord-010119-t1x9gknd 10032 1 Of of IN cord-010119-t1x9gknd 10032 2 the the DT cord-010119-t1x9gknd 10032 3 9 9 CD cord-010119-t1x9gknd 10032 4 donors donor NNS cord-010119-t1x9gknd 10032 5 , , , cord-010119-t1x9gknd 10032 6 7 7 CD cord-010119-t1x9gknd 10032 7 were be VBD cord-010119-t1x9gknd 10032 8 from from IN cord-010119-t1x9gknd 10032 9 Quebec Quebec NNP cord-010119-t1x9gknd 10032 10 , , , cord-010119-t1x9gknd 10032 11 and and CC cord-010119-t1x9gknd 10032 12 one one CD cord-010119-t1x9gknd 10032 13 each each DT cord-010119-t1x9gknd 10032 14 from from IN cord-010119-t1x9gknd 10032 15 Nova Nova NNP cord-010119-t1x9gknd 10032 16 Scotia Scotia NNP cord-010119-t1x9gknd 10032 17 and and CC cord-010119-t1x9gknd 10032 18 Alberta Alberta NNP cord-010119-t1x9gknd 10032 19 ( ( -LRB- cord-010119-t1x9gknd 10032 20 7 7 CD cord-010119-t1x9gknd 10032 21 male male NN cord-010119-t1x9gknd 10032 22 , , , cord-010119-t1x9gknd 10032 23 2 2 CD cord-010119-t1x9gknd 10032 24 female female NN cord-010119-t1x9gknd 10032 25 ) ) -RRB- cord-010119-t1x9gknd 10032 26 . . . cord-010119-t1x9gknd 10033 1 Ages age NNS cord-010119-t1x9gknd 10033 2 ranged range VBD cord-010119-t1x9gknd 10033 3 from from IN cord-010119-t1x9gknd 10033 4 21 21 CD cord-010119-t1x9gknd 10033 5 to to TO cord-010119-t1x9gknd 10033 6 70 70 CD cord-010119-t1x9gknd 10033 7 years year NNS cord-010119-t1x9gknd 10033 8 . . . cord-010119-t1x9gknd 10034 1 Only only RB cord-010119-t1x9gknd 10034 2 two two CD cord-010119-t1x9gknd 10034 3 donors donor NNS cord-010119-t1x9gknd 10034 4 reported report VBD cord-010119-t1x9gknd 10034 5 non non JJ cord-010119-t1x9gknd 10034 6 - - JJ cord-010119-t1x9gknd 10034 7 specific specific JJ cord-010119-t1x9gknd 10034 8 symptoms symptom NNS cord-010119-t1x9gknd 10034 9 ( ( -LRB- cord-010119-t1x9gknd 10034 10 fatigue fatigue NN cord-010119-t1x9gknd 10034 11 ) ) -RRB- cord-010119-t1x9gknd 10034 12 . . . cord-010119-t1x9gknd 10035 1 In in IN cord-010119-t1x9gknd 10035 2 terms term NNS cord-010119-t1x9gknd 10035 3 of of IN cord-010119-t1x9gknd 10035 4 risk risk NN cord-010119-t1x9gknd 10035 5 factors factor NNS cord-010119-t1x9gknd 10035 6 : : : cord-010119-t1x9gknd 10035 7 6 6 CD cord-010119-t1x9gknd 10035 8 ate eat VBD cord-010119-t1x9gknd 10035 9 pork pork NN cord-010119-t1x9gknd 10035 10 ( ( -LRB- cord-010119-t1x9gknd 10035 11 including include VBG cord-010119-t1x9gknd 10035 12 3 3 CD cord-010119-t1x9gknd 10035 13 who who WP cord-010119-t1x9gknd 10035 14 ate eat VBD cord-010119-t1x9gknd 10035 15 pork pork NN cord-010119-t1x9gknd 10035 16 liver liver NN cord-010119-t1x9gknd 10035 17 ) ) -RRB- cord-010119-t1x9gknd 10035 18 , , , cord-010119-t1x9gknd 10035 19 4 4 CD cord-010119-t1x9gknd 10035 20 ate eat VBD cord-010119-t1x9gknd 10035 21 shellfish shellfish NN cord-010119-t1x9gknd 10035 22 , , , cord-010119-t1x9gknd 10035 23 2 2 CD cord-010119-t1x9gknd 10035 24 ate eat VBD cord-010119-t1x9gknd 10035 25 venison venison NN cord-010119-t1x9gknd 10035 26 , , , cord-010119-t1x9gknd 10035 27 and and CC cord-010119-t1x9gknd 10035 28 3 3 CD cord-010119-t1x9gknd 10035 29 drank drink VBD cord-010119-t1x9gknd 10035 30 well well JJ cord-010119-t1x9gknd 10035 31 water water NN cord-010119-t1x9gknd 10035 32 . . . cord-010119-t1x9gknd 10036 1 One one CD cord-010119-t1x9gknd 10036 2 donor donor NN cord-010119-t1x9gknd 10036 3 had have VBD cord-010119-t1x9gknd 10036 4 no no DT cord-010119-t1x9gknd 10036 5 identifiable identifiable JJ cord-010119-t1x9gknd 10036 6 risk risk NN cord-010119-t1x9gknd 10036 7 factor factor NN cord-010119-t1x9gknd 10036 8 . . . cord-010119-t1x9gknd 10037 1 Viral viral JJ cord-010119-t1x9gknd 10037 2 loads load NNS cord-010119-t1x9gknd 10037 3 ranged range VBD cord-010119-t1x9gknd 10037 4 from from IN cord-010119-t1x9gknd 10037 5 3 3 CD cord-010119-t1x9gknd 10037 6 to to IN cord-010119-t1x9gknd 10037 7 151 151 CD cord-010119-t1x9gknd 10037 8 IU IU NNP cord-010119-t1x9gknd 10037 9 / / SYM cord-010119-t1x9gknd 10037 10 mL ml NN cord-010119-t1x9gknd 10037 11 , , , cord-010119-t1x9gknd 10037 12 of of IN cord-010119-t1x9gknd 10037 13 which which WDT cord-010119-t1x9gknd 10037 14 2 2 CD cord-010119-t1x9gknd 10037 15 were be VBD cord-010119-t1x9gknd 10037 16 < < NNP cord-010119-t1x9gknd 10037 17 10 10 CD cord-010119-t1x9gknd 10037 18 , , , cord-010119-t1x9gknd 10038 1 3 3 CD cord-010119-t1x9gknd 10038 2 were be VBD cord-010119-t1x9gknd 10038 3 10 10 CD cord-010119-t1x9gknd 10038 4 - - SYM cord-010119-t1x9gknd 10038 5 50 50 CD cord-010119-t1x9gknd 10038 6 , , , cord-010119-t1x9gknd 10038 7 and and CC cord-010119-t1x9gknd 10038 8 3 3 CD cord-010119-t1x9gknd 10038 9 were be VBD cord-010119-t1x9gknd 10038 10 > > XX cord-010119-t1x9gknd 10038 11 50 50 CD cord-010119-t1x9gknd 10038 12 IU IU NNP cord-010119-t1x9gknd 10038 13 / / SYM cord-010119-t1x9gknd 10038 14 mL ml NN cord-010119-t1x9gknd 10038 15 ; ; : cord-010119-t1x9gknd 10039 1 2 2 CD cord-010119-t1x9gknd 10039 2 were be VBD cord-010119-t1x9gknd 10039 3 anti anti JJ cord-010119-t1x9gknd 10039 4 - - JJ cord-010119-t1x9gknd 10039 5 HEV hev JJ cord-010119-t1x9gknd 10039 6 IgM IgM NNP cord-010119-t1x9gknd 10039 7 positive positive JJ cord-010119-t1x9gknd 10039 8 and and CC cord-010119-t1x9gknd 10039 9 4 4 CD cord-010119-t1x9gknd 10039 10 anti anti JJ cord-010119-t1x9gknd 10039 11 - - JJ cord-010119-t1x9gknd 10039 12 HEV hev JJ cord-010119-t1x9gknd 10039 13 IgG igg NN cord-010119-t1x9gknd 10039 14 positive positive JJ cord-010119-t1x9gknd 10039 15 at at IN cord-010119-t1x9gknd 10039 16 index index NN cord-010119-t1x9gknd 10039 17 ( ( -LRB- cord-010119-t1x9gknd 10039 18 Wantai Wantai NNP cord-010119-t1x9gknd 10039 19 assay assay NN cord-010119-t1x9gknd 10039 20 ) ) -RRB- cord-010119-t1x9gknd 10039 21 . . . cord-010119-t1x9gknd 10040 1 Conclusion conclusion NN cord-010119-t1x9gknd 10040 2 : : : cord-010119-t1x9gknd 10041 1 The the DT cord-010119-t1x9gknd 10041 2 prevalence prevalence NN cord-010119-t1x9gknd 10041 3 rate rate NN cord-010119-t1x9gknd 10041 4 of of IN cord-010119-t1x9gknd 10041 5 acute acute JJ cord-010119-t1x9gknd 10041 6 HEV HEV NNP cord-010119-t1x9gknd 10041 7 infection infection NN cord-010119-t1x9gknd 10041 8 in in IN cord-010119-t1x9gknd 10041 9 this this DT cord-010119-t1x9gknd 10041 10 donor donor NN cord-010119-t1x9gknd 10041 11 population population NN cord-010119-t1x9gknd 10041 12 appears appear VBZ cord-010119-t1x9gknd 10041 13 to to TO cord-010119-t1x9gknd 10041 14 be be VB cord-010119-t1x9gknd 10041 15 around around IN cord-010119-t1x9gknd 10041 16 1/4400 1/4400 CD cord-010119-t1x9gknd 10041 17 . . . cord-010119-t1x9gknd 10042 1 The the DT cord-010119-t1x9gknd 10042 2 data datum NNS cord-010119-t1x9gknd 10042 3 from from IN cord-010119-t1x9gknd 10042 4 this this DT cord-010119-t1x9gknd 10042 5 study study NN cord-010119-t1x9gknd 10042 6 will will MD cord-010119-t1x9gknd 10042 7 contribute contribute VB cord-010119-t1x9gknd 10042 8 to to IN cord-010119-t1x9gknd 10042 9 the the DT cord-010119-t1x9gknd 10042 10 ongoing ongoing JJ cord-010119-t1x9gknd 10042 11 risk risk NN cord-010119-t1x9gknd 10042 12 assessment assessment NN cord-010119-t1x9gknd 10042 13 of of IN cord-010119-t1x9gknd 10042 14 transfusion transfusion NN cord-010119-t1x9gknd 10042 15 - - HYPH cord-010119-t1x9gknd 10042 16 transmitted transmit VBN cord-010119-t1x9gknd 10042 17 HEV hev NN cord-010119-t1x9gknd 10042 18 infection infection NN cord-010119-t1x9gknd 10042 19 in in IN cord-010119-t1x9gknd 10042 20 Canada Canada NNP cord-010119-t1x9gknd 10042 21 . . . cord-010119-t1x9gknd 10043 1 Prevalence prevalence NN cord-010119-t1x9gknd 10043 2 of of IN cord-010119-t1x9gknd 10043 3 Malaria Malaria NNP cord-010119-t1x9gknd 10043 4 Parasite Parasite NNP cord-010119-t1x9gknd 10043 5 in in IN cord-010119-t1x9gknd 10043 6 Donated donate VBN cord-010119-t1x9gknd 10043 7 Blood blood NN cord-010119-t1x9gknd 10043 8 at at IN cord-010119-t1x9gknd 10043 9 Nakasero Nakasero NNP cord-010119-t1x9gknd 10043 10 Blood Blood NNP cord-010119-t1x9gknd 10043 11 BANK BANK NNP cord-010119-t1x9gknd 10043 12 , , , cord-010119-t1x9gknd 10043 13 Uganda Uganda NNP cord-010119-t1x9gknd 10043 14 Gerald Gerald NNP cord-010119-t1x9gknd 10043 15 Nsubuga Nsubuga NNP cord-010119-t1x9gknd 10043 16 * * NFP cord-010119-t1x9gknd 10043 17 and and CC cord-010119-t1x9gknd 10043 18 Musiisi Musiisi NNP cord-010119-t1x9gknd 10043 19 Ezra Ezra NNP cord-010119-t1x9gknd 10043 20 . . . cord-010119-t1x9gknd 10044 1 UGANDA UGANDA NNP cord-010119-t1x9gknd 10044 2 BLOOD BLOOD NNP cord-010119-t1x9gknd 10044 3 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 10044 4 SERVICE service NN cord-010119-t1x9gknd 10045 1 Background Background NNP cord-010119-t1x9gknd 10045 2 / / SYM cord-010119-t1x9gknd 10045 3 Case Case NNP cord-010119-t1x9gknd 10045 4 Studies Studies NNPS cord-010119-t1x9gknd 10045 5 : : : cord-010119-t1x9gknd 10046 1 Introduction introduction NN cord-010119-t1x9gknd 10046 2 Infectivity infectivity NN cord-010119-t1x9gknd 10046 3 of of IN cord-010119-t1x9gknd 10046 4 donated donate VBN cord-010119-t1x9gknd 10046 5 blood blood NN cord-010119-t1x9gknd 10046 6 with with IN cord-010119-t1x9gknd 10046 7 malaria malaria NN cord-010119-t1x9gknd 10046 8 is be VBZ cord-010119-t1x9gknd 10046 9 a a DT cord-010119-t1x9gknd 10046 10 significant significant JJ cord-010119-t1x9gknd 10046 11 health health NN cord-010119-t1x9gknd 10046 12 problem problem NN cord-010119-t1x9gknd 10046 13 facing face VBG cord-010119-t1x9gknd 10046 14 humanity humanity NN cord-010119-t1x9gknd 10046 15 . . . cord-010119-t1x9gknd 10047 1 In in IN cord-010119-t1x9gknd 10047 2 Uganda Uganda NNP cord-010119-t1x9gknd 10047 3 , , , cord-010119-t1x9gknd 10047 4 screening screen VBG cord-010119-t1x9gknd 10047 5 for for IN cord-010119-t1x9gknd 10047 6 malaria malaria NN cord-010119-t1x9gknd 10047 7 parasite parasite NN cord-010119-t1x9gknd 10047 8 is be VBZ cord-010119-t1x9gknd 10047 9 neither neither CC cord-010119-t1x9gknd 10047 10 routinely routinely RB cord-010119-t1x9gknd 10047 11 done do VBN cord-010119-t1x9gknd 10047 12 in in IN cord-010119-t1x9gknd 10047 13 blood blood NN cord-010119-t1x9gknd 10047 14 banks bank NNS cord-010119-t1x9gknd 10047 15 , , , cord-010119-t1x9gknd 10047 16 nor nor CC cord-010119-t1x9gknd 10047 17 stipulated stipulate VBN cord-010119-t1x9gknd 10047 18 in in IN cord-010119-t1x9gknd 10047 19 the the DT cord-010119-t1x9gknd 10047 20 current current JJ cord-010119-t1x9gknd 10047 21 Uganda Uganda NNP cord-010119-t1x9gknd 10047 22 National National NNP cord-010119-t1x9gknd 10047 23 Blood Blood NNP cord-010119-t1x9gknd 10047 24 Transfusion Transfusion NNP cord-010119-t1x9gknd 10047 25 Service Service NNP cord-010119-t1x9gknd 10047 26 ( ( -LRB- cord-010119-t1x9gknd 10047 27 UBTS UBTS NNP cord-010119-t1x9gknd 10047 28 ) ) -RRB- cord-010119-t1x9gknd 10047 29 guidelines guideline NNS cord-010119-t1x9gknd 10047 30 by by IN cord-010119-t1x9gknd 10047 31 the the DT cord-010119-t1x9gknd 10047 32 Ministry Ministry NNP cord-010119-t1x9gknd 10047 33 of of IN cord-010119-t1x9gknd 10047 34 Health Health NNP cord-010119-t1x9gknd 10047 35 . . . cord-010119-t1x9gknd 10048 1 As as IN cord-010119-t1x9gknd 10048 2 a a DT cord-010119-t1x9gknd 10048 3 result result NN cord-010119-t1x9gknd 10048 4 , , , cord-010119-t1x9gknd 10048 5 the the DT cord-010119-t1x9gknd 10048 6 proportion proportion NN cord-010119-t1x9gknd 10048 7 of of IN cord-010119-t1x9gknd 10048 8 donated donate VBN cord-010119-t1x9gknd 10048 9 blood blood NN cord-010119-t1x9gknd 10048 10 that that WDT cord-010119-t1x9gknd 10048 11 is be VBZ cord-010119-t1x9gknd 10048 12 infected infect VBN cord-010119-t1x9gknd 10048 13 with with IN cord-010119-t1x9gknd 10048 14 malaria malaria NN cord-010119-t1x9gknd 10048 15 is be VBZ cord-010119-t1x9gknd 10048 16 largely largely RB cord-010119-t1x9gknd 10048 17 unknown unknown JJ cord-010119-t1x9gknd 10048 18 . . . cord-010119-t1x9gknd 10049 1 Malaria malaria NN cord-010119-t1x9gknd 10049 2 infection infection NN cord-010119-t1x9gknd 10049 3 places place VBZ cord-010119-t1x9gknd 10049 4 more more JJR cord-010119-t1x9gknd 10049 5 than than IN cord-010119-t1x9gknd 10049 6 half half NN cord-010119-t1x9gknd 10049 7 of of IN cord-010119-t1x9gknd 10049 8 the the DT cord-010119-t1x9gknd 10049 9 world world NN cord-010119-t1x9gknd 10049 10 's 's POS cord-010119-t1x9gknd 10049 11 population population NN cord-010119-t1x9gknd 10049 12 at at IN cord-010119-t1x9gknd 10049 13 risk risk NN cord-010119-t1x9gknd 10049 14 and and CC cord-010119-t1x9gknd 10049 15 in in IN cord-010119-t1x9gknd 10049 16 majority majority NN cord-010119-t1x9gknd 10049 17 of of IN cord-010119-t1x9gknd 10049 18 the the DT cord-010119-t1x9gknd 10049 19 tropical tropical JJ cord-010119-t1x9gknd 10049 20 and and CC cord-010119-t1x9gknd 10049 21 sub sub JJ cord-010119-t1x9gknd 10049 22 - - JJ cord-010119-t1x9gknd 10049 23 tropical tropical JJ cord-010119-t1x9gknd 10049 24 regions region NNS cord-010119-t1x9gknd 10049 25 of of IN cord-010119-t1x9gknd 10049 26 the the DT cord-010119-t1x9gknd 10049 27 world world NN cord-010119-t1x9gknd 10049 28 and and CC cord-010119-t1x9gknd 10049 29 about about RB cord-010119-t1x9gknd 10049 30 300 300 CD cord-010119-t1x9gknd 10049 31 to to TO cord-010119-t1x9gknd 10049 32 500 500 CD cord-010119-t1x9gknd 10049 33 million million CD cord-010119-t1x9gknd 10049 34 cases case NNS cord-010119-t1x9gknd 10049 35 and and CC cord-010119-t1x9gknd 10049 36 2 2 CD cord-010119-t1x9gknd 10049 37 to to TO cord-010119-t1x9gknd 10049 38 3 3 CD cord-010119-t1x9gknd 10049 39 million million CD cord-010119-t1x9gknd 10049 40 death death NN cord-010119-t1x9gknd 10049 41 occur occur VBP cord-010119-t1x9gknd 10049 42 per per IN cord-010119-t1x9gknd 10049 43 year year NN cord-010119-t1x9gknd 10049 44 . . . cord-010119-t1x9gknd 10050 1 However however RB cord-010119-t1x9gknd 10050 2 the the DT cord-010119-t1x9gknd 10050 3 study study NN cord-010119-t1x9gknd 10050 4 aimed aim VBN cord-010119-t1x9gknd 10050 5 at at IN cord-010119-t1x9gknd 10050 6 determining determine VBG cord-010119-t1x9gknd 10050 7 the the DT cord-010119-t1x9gknd 10050 8 prevalence prevalence NN cord-010119-t1x9gknd 10050 9 of of IN cord-010119-t1x9gknd 10050 10 malaria malaria NN cord-010119-t1x9gknd 10050 11 parasites parasite NNS cord-010119-t1x9gknd 10050 12 in in IN cord-010119-t1x9gknd 10050 13 donated donate VBN cord-010119-t1x9gknd 10050 14 blood blood NN cord-010119-t1x9gknd 10050 15 at at IN cord-010119-t1x9gknd 10050 16 Nakasero Nakasero NNP cord-010119-t1x9gknd 10050 17 Blood Blood NNP cord-010119-t1x9gknd 10050 18 bank bank NN cord-010119-t1x9gknd 10050 19 , , , cord-010119-t1x9gknd 10050 20 Kampala Kampala NNP cord-010119-t1x9gknd 10050 21 , , , cord-010119-t1x9gknd 10050 22 Uganda Uganda NNP cord-010119-t1x9gknd 10050 23 Study Study NNP cord-010119-t1x9gknd 10050 24 Design Design NNP cord-010119-t1x9gknd 10050 25 / / SYM cord-010119-t1x9gknd 10050 26 Method method NN cord-010119-t1x9gknd 10050 27 : : : cord-010119-t1x9gknd 10050 28 A a DT cord-010119-t1x9gknd 10050 29 cross cross JJ cord-010119-t1x9gknd 10050 30 sectional sectional JJ cord-010119-t1x9gknd 10050 31 study study NN cord-010119-t1x9gknd 10050 32 was be VBD cord-010119-t1x9gknd 10050 33 carried carry VBN cord-010119-t1x9gknd 10050 34 out out RP cord-010119-t1x9gknd 10050 35 in in IN cord-010119-t1x9gknd 10050 36 Nakasero Nakasero NNP cord-010119-t1x9gknd 10050 37 blood blood NN cord-010119-t1x9gknd 10050 38 bank bank NN cord-010119-t1x9gknd 10050 39 , , , cord-010119-t1x9gknd 10050 40 Kampala Kampala NNP cord-010119-t1x9gknd 10050 41 , , , cord-010119-t1x9gknd 10050 42 Uganda Uganda NNP cord-010119-t1x9gknd 10050 43 in in IN cord-010119-t1x9gknd 10050 44 four four CD cord-010119-t1x9gknd 10050 45 hundred hundred CD cord-010119-t1x9gknd 10050 46 and and CC cord-010119-t1x9gknd 10050 47 seventy seventy CD cord-010119-t1x9gknd 10050 48 randomly randomly RB cord-010119-t1x9gknd 10050 49 selected select VBN cord-010119-t1x9gknd 10050 50 donor donor NN cord-010119-t1x9gknd 10050 51 samples sample NNS cord-010119-t1x9gknd 10050 52 at at IN cord-010119-t1x9gknd 10050 53 the the DT cord-010119-t1x9gknd 10050 54 blood blood NN cord-010119-t1x9gknd 10050 55 bank bank NN cord-010119-t1x9gknd 10050 56 between between IN cord-010119-t1x9gknd 10050 57 June June NNP cord-010119-t1x9gknd 10050 58 and and CC cord-010119-t1x9gknd 10050 59 August August NNP cord-010119-t1x9gknd 10050 60 2014 2014 CD cord-010119-t1x9gknd 10050 61 . . . cord-010119-t1x9gknd 10051 1 Both both CC cord-010119-t1x9gknd 10051 2 thin thin JJ cord-010119-t1x9gknd 10051 3 and and CC cord-010119-t1x9gknd 10051 4 thick thick JJ cord-010119-t1x9gknd 10051 5 glass glass NN cord-010119-t1x9gknd 10051 6 stained stain VBN cord-010119-t1x9gknd 10051 7 blood blood NN cord-010119-t1x9gknd 10051 8 smears smear NNS cord-010119-t1x9gknd 10051 9 of of IN cord-010119-t1x9gknd 10051 10 417 417 CD cord-010119-t1x9gknd 10051 11 blood blood NN cord-010119-t1x9gknd 10051 12 samples sample NNS cord-010119-t1x9gknd 10051 13 with with IN cord-010119-t1x9gknd 10051 14 Giemsa Giemsa NNP cord-010119-t1x9gknd 10051 15 was be VBD cord-010119-t1x9gknd 10051 16 examined examine VBN cord-010119-t1x9gknd 10051 17 using use VBG cord-010119-t1x9gknd 10051 18 microscope microscope NN cord-010119-t1x9gknd 10051 19 . . . cord-010119-t1x9gknd 10052 1 Results result NNS cord-010119-t1x9gknd 10053 1 /Finding /finde VBG cord-010119-t1x9gknd 10053 2 : : : cord-010119-t1x9gknd 10053 3 Of of IN cord-010119-t1x9gknd 10053 4 the the DT cord-010119-t1x9gknd 10053 5 417 417 CD cord-010119-t1x9gknd 10053 6 donated donate VBN cord-010119-t1x9gknd 10053 7 blood blood NN cord-010119-t1x9gknd 10053 8 samples sample NNS cord-010119-t1x9gknd 10053 9 , , , cord-010119-t1x9gknd 10053 10 17 17 CD cord-010119-t1x9gknd 10053 11 ( ( -LRB- cord-010119-t1x9gknd 10053 12 4.1 4.1 CD cord-010119-t1x9gknd 10053 13 % % NN cord-010119-t1x9gknd 10053 14 ) ) -RRB- cord-010119-t1x9gknd 10053 15 tested test VBD cord-010119-t1x9gknd 10053 16 positive positive JJ cord-010119-t1x9gknd 10053 17 for for IN cord-010119-t1x9gknd 10053 18 malaria malaria NN cord-010119-t1x9gknd 10053 19 parasite parasite NN cord-010119-t1x9gknd 10053 20 ( ( -LRB- cord-010119-t1x9gknd 10053 21 p. p. NN cord-010119-t1x9gknd 10053 22 falciparum falciparum NNP cord-010119-t1x9gknd 10053 23 ) ) -RRB- cord-010119-t1x9gknd 10053 24 , , , cord-010119-t1x9gknd 10053 25 although although IN cord-010119-t1x9gknd 10053 26 there there EX cord-010119-t1x9gknd 10053 27 was be VBD cord-010119-t1x9gknd 10053 28 no no DT cord-010119-t1x9gknd 10053 29 significant significant JJ cord-010119-t1x9gknd 10053 30 difference difference NN cord-010119-t1x9gknd 10053 31 in in IN cord-010119-t1x9gknd 10053 32 occurrence occurrence NN cord-010119-t1x9gknd 10053 33 of of IN cord-010119-t1x9gknd 10053 34 Plasmodium plasmodium NN cord-010119-t1x9gknd 10053 35 in in IN cord-010119-t1x9gknd 10053 36 relation relation NN cord-010119-t1x9gknd 10053 37 to to IN cord-010119-t1x9gknd 10053 38 sex sex NN cord-010119-t1x9gknd 10053 39 , , , cord-010119-t1x9gknd 10053 40 age age NN cord-010119-t1x9gknd 10053 41 and and CC cord-010119-t1x9gknd 10053 42 blood blood NN cord-010119-t1x9gknd 10053 43 group group NN cord-010119-t1x9gknd 10053 44 ( ( -LRB- cord-010119-t1x9gknd 10053 45 P>0.05 P>0.05 NNP cord-010119-t1x9gknd 10053 46 ) ) -RRB- cord-010119-t1x9gknd 10053 47 , , , cord-010119-t1x9gknd 10053 48 majority majority NN cord-010119-t1x9gknd 10053 49 of of IN cord-010119-t1x9gknd 10053 50 the the DT cord-010119-t1x9gknd 10053 51 blood blood NN cord-010119-t1x9gknd 10053 52 donors donor NNS cord-010119-t1x9gknd 10053 53 that that WDT cord-010119-t1x9gknd 10053 54 tested test VBD cord-010119-t1x9gknd 10053 55 positive positive JJ cord-010119-t1x9gknd 10053 56 belonged belong VBD cord-010119-t1x9gknd 10053 57 to to IN cord-010119-t1x9gknd 10053 58 blood blood NN cord-010119-t1x9gknd 10053 59 group group NN cord-010119-t1x9gknd 10053 60 O o NN cord-010119-t1x9gknd 10053 61 ( ( -LRB- cord-010119-t1x9gknd 10053 62 64.71 64.71 CD cord-010119-t1x9gknd 10053 63 % % NN cord-010119-t1x9gknd 10053 64 ) ) -RRB- cord-010119-t1x9gknd 10053 65 . . . cord-010119-t1x9gknd 10054 1 The the DT cord-010119-t1x9gknd 10054 2 prevalence prevalence NN cord-010119-t1x9gknd 10054 3 of of IN cord-010119-t1x9gknd 10054 4 malaria malaria NN cord-010119-t1x9gknd 10054 5 parasite parasite NN cord-010119-t1x9gknd 10054 6 in in IN cord-010119-t1x9gknd 10054 7 the the DT cord-010119-t1x9gknd 10054 8 study study NN cord-010119-t1x9gknd 10054 9 was be VBD cord-010119-t1x9gknd 10054 10 4.1 4.1 CD cord-010119-t1x9gknd 10054 11 % % NN cord-010119-t1x9gknd 10054 12 . . . cord-010119-t1x9gknd 10055 1 Regardless regardless RB cord-010119-t1x9gknd 10055 2 of of IN cord-010119-t1x9gknd 10055 3 the the DT cord-010119-t1x9gknd 10055 4 prevalence prevalence NN cord-010119-t1x9gknd 10055 5 , , , cord-010119-t1x9gknd 10055 6 the the DT cord-010119-t1x9gknd 10055 7 presence presence NN cord-010119-t1x9gknd 10055 8 of of IN cord-010119-t1x9gknd 10055 9 malaria malaria NN cord-010119-t1x9gknd 10055 10 parasite parasite NN cord-010119-t1x9gknd 10055 11 ( ( -LRB- cord-010119-t1x9gknd 10055 12 Plasmodium Plasmodium NNP cord-010119-t1x9gknd 10055 13 falciparum falciparum NN cord-010119-t1x9gknd 10055 14 ) ) -RRB- cord-010119-t1x9gknd 10055 15 in in IN cord-010119-t1x9gknd 10055 16 donated donate VBN cord-010119-t1x9gknd 10055 17 blood blood NN cord-010119-t1x9gknd 10055 18 from from IN cord-010119-t1x9gknd 10055 19 donors donor NNS cord-010119-t1x9gknd 10055 20 that that WDT cord-010119-t1x9gknd 10055 21 were be VBD cord-010119-t1x9gknd 10055 22 presumed presume VBN cord-010119-t1x9gknd 10055 23 to to TO cord-010119-t1x9gknd 10055 24 be be VB cord-010119-t1x9gknd 10055 25 healthy healthy JJ cord-010119-t1x9gknd 10055 26 raises raise VBZ cord-010119-t1x9gknd 10055 27 a a DT cord-010119-t1x9gknd 10055 28 serious serious JJ cord-010119-t1x9gknd 10055 29 concern concern NN cord-010119-t1x9gknd 10055 30 on on IN cord-010119-t1x9gknd 10055 31 the the DT cord-010119-t1x9gknd 10055 32 safety safety NN cord-010119-t1x9gknd 10055 33 of of IN cord-010119-t1x9gknd 10055 34 donated donate VBN cord-010119-t1x9gknd 10055 35 blood blood NN cord-010119-t1x9gknd 10055 36 in in IN cord-010119-t1x9gknd 10055 37 Uganda Uganda NNP cord-010119-t1x9gknd 10055 38 . . . cord-010119-t1x9gknd 10056 1 The the DT cord-010119-t1x9gknd 10056 2 Ministry Ministry NNP cord-010119-t1x9gknd 10056 3 of of IN cord-010119-t1x9gknd 10056 4 Health Health NNP cord-010119-t1x9gknd 10056 5 should should MD cord-010119-t1x9gknd 10056 6 review review VB cord-010119-t1x9gknd 10056 7 the the DT cord-010119-t1x9gknd 10056 8 existing exist VBG cord-010119-t1x9gknd 10056 9 guidelines guideline NNS cord-010119-t1x9gknd 10056 10 for for IN cord-010119-t1x9gknd 10056 11 screening screen VBG cord-010119-t1x9gknd 10056 12 malaria malaria NN cord-010119-t1x9gknd 10056 13 and and CC cord-010119-t1x9gknd 10056 14 mandatory mandatory JJ cord-010119-t1x9gknd 10056 15 universal universal JJ cord-010119-t1x9gknd 10056 16 blood blood NN cord-010119-t1x9gknd 10056 17 donor donor NN cord-010119-t1x9gknd 10056 18 screening screening NN cord-010119-t1x9gknd 10056 19 policy policy NN cord-010119-t1x9gknd 10056 20 for for IN cord-010119-t1x9gknd 10056 21 malaria malaria NN cord-010119-t1x9gknd 10056 22 , , , cord-010119-t1x9gknd 10056 23 for for IN cord-010119-t1x9gknd 10056 24 exclusion exclusion NN cord-010119-t1x9gknd 10056 25 of of IN cord-010119-t1x9gknd 10056 26 blood blood NN cord-010119-t1x9gknd 10056 27 donors donor NNS cord-010119-t1x9gknd 10056 28 with with IN cord-010119-t1x9gknd 10056 29 plasmodia plasmodia NNP cord-010119-t1x9gknd 10056 30 parasitaemia parasitaemia NNP cord-010119-t1x9gknd 10056 31 . . . cord-010119-t1x9gknd 10057 1 Using use VBG cord-010119-t1x9gknd 10057 2 methods method NNS cord-010119-t1x9gknd 10057 3 like like IN cord-010119-t1x9gknd 10057 4 pathogen pathogen NN cord-010119-t1x9gknd 10057 5 inactivation inactivation NN cord-010119-t1x9gknd 10057 6 compared compare VBN cord-010119-t1x9gknd 10057 7 to to IN cord-010119-t1x9gknd 10057 8 tedious tedious JJ cord-010119-t1x9gknd 10057 9 microscopic microscopic JJ cord-010119-t1x9gknd 10057 10 procedure procedure NN cord-010119-t1x9gknd 10057 11 to to IN cord-010119-t1x9gknd 10057 12 screen screen NN cord-010119-t1x9gknd 10057 13 donated donate VBN cord-010119-t1x9gknd 10057 14 blood blood NN cord-010119-t1x9gknd 10057 15 to to TO cord-010119-t1x9gknd 10057 16 be be VB cord-010119-t1x9gknd 10057 17 introduced introduce VBN cord-010119-t1x9gknd 10057 18 to to TO cord-010119-t1x9gknd 10057 19 further further RB cord-010119-t1x9gknd 10057 20 enhance enhance VB cord-010119-t1x9gknd 10057 21 blood blood NN cord-010119-t1x9gknd 10057 22 safety safety NN cord-010119-t1x9gknd 10057 23 in in IN cord-010119-t1x9gknd 10057 24 our -PRON- PRP$ cord-010119-t1x9gknd 10057 25 communities community NNS cord-010119-t1x9gknd 10057 26 . . . cord-010119-t1x9gknd 10058 1 components component NNS cord-010119-t1x9gknd 10058 2 . . . cord-010119-t1x9gknd 10059 1 The the DT cord-010119-t1x9gknd 10059 2 BacT BacT NNP cord-010119-t1x9gknd 10059 3 / / SYM cord-010119-t1x9gknd 10059 4 ALERT alert VBP cord-010119-t1x9gknd 10059 5 VIRTUO VIRTUO NNS cord-010119-t1x9gknd 10059 6 * * NFP cord-010119-t1x9gknd 10059 7 ( ( -LRB- cord-010119-t1x9gknd 10059 8 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 10059 9 ) ) -RRB- cord-010119-t1x9gknd 10059 10 is be VBZ cord-010119-t1x9gknd 10059 11 an an DT cord-010119-t1x9gknd 10059 12 advanced advanced JJ cord-010119-t1x9gknd 10059 13 , , , cord-010119-t1x9gknd 10059 14 next next JJ cord-010119-t1x9gknd 10059 15 generation generation NN cord-010119-t1x9gknd 10059 16 system system NN cord-010119-t1x9gknd 10059 17 with with IN cord-010119-t1x9gknd 10059 18 improved improved JJ cord-010119-t1x9gknd 10059 19 automation automation NN cord-010119-t1x9gknd 10059 20 , , , cord-010119-t1x9gknd 10059 21 connectivity connectivity NN cord-010119-t1x9gknd 10059 22 , , , cord-010119-t1x9gknd 10059 23 and and CC cord-010119-t1x9gknd 10059 24 with with IN cord-010119-t1x9gknd 10059 25 data datum NNS cord-010119-t1x9gknd 10059 26 management management NN cord-010119-t1x9gknd 10059 27 systems system NNS cord-010119-t1x9gknd 10059 28 . . . cord-010119-t1x9gknd 10060 1 Most most RBS cord-010119-t1x9gknd 10060 2 importantly importantly RB cord-010119-t1x9gknd 10060 3 , , , cord-010119-t1x9gknd 10060 4 the the DT cord-010119-t1x9gknd 10060 5 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 10060 6 's 's POS cord-010119-t1x9gknd 10060 7 new new JJ cord-010119-t1x9gknd 10060 8 algorithm algorithm NN cord-010119-t1x9gknd 10060 9 significantly significantly RB cord-010119-t1x9gknd 10060 10 reduces reduce VBZ cord-010119-t1x9gknd 10060 11 the the DT cord-010119-t1x9gknd 10060 12 time time NN cord-010119-t1x9gknd 10060 13 to to IN cord-010119-t1x9gknd 10060 14 detection detection NN cord-010119-t1x9gknd 10060 15 ( ( -LRB- cord-010119-t1x9gknd 10060 16 TTD TTD NNP cord-010119-t1x9gknd 10060 17 ) ) -RRB- cord-010119-t1x9gknd 10060 18 of of IN cord-010119-t1x9gknd 10060 19 microorganisms microorganism NNS cord-010119-t1x9gknd 10060 20 during during IN cord-010119-t1x9gknd 10060 21 quality quality NN cord-010119-t1x9gknd 10060 22 control control NN cord-010119-t1x9gknd 10060 23 testing testing NN cord-010119-t1x9gknd 10060 24 of of IN cord-010119-t1x9gknd 10060 25 platelet platelet NN cord-010119-t1x9gknd 10060 26 preparations preparation NNS cord-010119-t1x9gknd 10060 27 using use VBG cord-010119-t1x9gknd 10060 28 BacT BacT NNP cord-010119-t1x9gknd 10060 29 / / SYM cord-010119-t1x9gknd 10060 30 ALERT ALERT NNP cord-010119-t1x9gknd 10060 31 BPA BPA NNP cord-010119-t1x9gknd 10060 32 ( ( -LRB- cord-010119-t1x9gknd 10060 33 aerobic aerobic NN cord-010119-t1x9gknd 10060 34 ) ) -RRB- cord-010119-t1x9gknd 10060 35 and and CC cord-010119-t1x9gknd 10060 36 BPN BPN NNP cord-010119-t1x9gknd 10060 37 ( ( -LRB- cord-010119-t1x9gknd 10060 38 anaerobic anaerobic JJ cord-010119-t1x9gknd 10060 39 ) ) -RRB- cord-010119-t1x9gknd 10060 40 bottles bottle NNS cord-010119-t1x9gknd 10060 41 . . . cord-010119-t1x9gknd 10061 1 BPA BPA NNP cord-010119-t1x9gknd 10061 2 and and CC cord-010119-t1x9gknd 10061 3 BPN BPN NNP cord-010119-t1x9gknd 10061 4 bottles bottle NNS cord-010119-t1x9gknd 10061 5 were be VBD cord-010119-t1x9gknd 10061 6 tested test VBN cord-010119-t1x9gknd 10061 7 on on IN cord-010119-t1x9gknd 10061 8 VIRTUO VIRTUO NNS cord-010119-t1x9gknd 10061 9 and and CC cord-010119-t1x9gknd 10061 10 BacT/ BacT/ NNP cord-010119-t1x9gknd 10061 11 ALERT ALERT NNP cord-010119-t1x9gknd 10061 12 3D 3D NNP cord-010119-t1x9gknd 10061 13 ( ( -LRB- cord-010119-t1x9gknd 10061 14 BTA BTA NNP cord-010119-t1x9gknd 10061 15 3D 3D NNP cord-010119-t1x9gknd 10061 16 ) ) -RRB- cord-010119-t1x9gknd 10061 17 to to TO cord-010119-t1x9gknd 10061 18 evaluate evaluate VB cord-010119-t1x9gknd 10061 19 repeatability repeatability NN cord-010119-t1x9gknd 10061 20 to to TO cord-010119-t1x9gknd 10061 21 detect detect VB cord-010119-t1x9gknd 10061 22 growth growth NN cord-010119-t1x9gknd 10061 23 in in IN cord-010119-t1x9gknd 10061 24 seeded seed VBN cord-010119-t1x9gknd 10061 25 Leukocyte Leukocyte NNP cord-010119-t1x9gknd 10061 26 Reduced Reduced NNP cord-010119-t1x9gknd 10061 27 Apheresis Apheresis NNP cord-010119-t1x9gknd 10061 28 Platelets platelet NNS cord-010119-t1x9gknd 10061 29 ( ( -LRB- cord-010119-t1x9gknd 10061 30 LRAP LRAP NNP cord-010119-t1x9gknd 10061 31 ) ) -RRB- cord-010119-t1x9gknd 10061 32 without without IN cord-010119-t1x9gknd 10061 33 Platelet platelet NN cord-010119-t1x9gknd 10061 34 additive additive NN cord-010119-t1x9gknd 10061 35 Solution solution NN cord-010119-t1x9gknd 10061 36 ( ( -LRB- cord-010119-t1x9gknd 10061 37 PAS PAS NNP cord-010119-t1x9gknd 10061 38 ) ) -RRB- cord-010119-t1x9gknd 10061 39 , , , cord-010119-t1x9gknd 10061 40 throughout throughout IN cord-010119-t1x9gknd 10061 41 platelet platelet NN cord-010119-t1x9gknd 10061 42 shelf shelf NN cord-010119-t1x9gknd 10061 43 life life NN cord-010119-t1x9gknd 10061 44 ( ( -LRB- cord-010119-t1x9gknd 10061 45 3 3 CD cord-010119-t1x9gknd 10061 46 , , , cord-010119-t1x9gknd 10061 47 4 4 CD cord-010119-t1x9gknd 10061 48 and and CC cord-010119-t1x9gknd 10061 49 5 5 CD cord-010119-t1x9gknd 10061 50 days day NNS cord-010119-t1x9gknd 10061 51 after after IN cord-010119-t1x9gknd 10061 52 collection collection NN cord-010119-t1x9gknd 10061 53 ) ) -RRB- cord-010119-t1x9gknd 10061 54 . . . cord-010119-t1x9gknd 10062 1 Study Study NNP cord-010119-t1x9gknd 10062 2 Design Design NNP cord-010119-t1x9gknd 10062 3 / / SYM cord-010119-t1x9gknd 10062 4 Method method NN cord-010119-t1x9gknd 10062 5 : : : cord-010119-t1x9gknd 10063 1 Pooled pool VBN cord-010119-t1x9gknd 10063 2 LRAP LRAP NNP cord-010119-t1x9gknd 10063 3 were be VBD cord-010119-t1x9gknd 10063 4 seeded seed VBN cord-010119-t1x9gknd 10063 5 with with IN cord-010119-t1x9gknd 10063 6 low low JJ cord-010119-t1x9gknd 10063 7 levels level NNS cord-010119-t1x9gknd 10063 8 of of IN cord-010119-t1x9gknd 10063 9 6 6 CD cord-010119-t1x9gknd 10063 10 organisms organism NNS cord-010119-t1x9gknd 10063 11 commonly commonly RB cord-010119-t1x9gknd 10063 12 associated associate VBN cord-010119-t1x9gknd 10063 13 with with IN cord-010119-t1x9gknd 10063 14 platelet platelet NN cord-010119-t1x9gknd 10063 15 contamination contamination NN cord-010119-t1x9gknd 10063 16 at at IN cord-010119-t1x9gknd 10063 17 3 3 CD cord-010119-t1x9gknd 10063 18 , , , cord-010119-t1x9gknd 10063 19 4 4 CD cord-010119-t1x9gknd 10063 20 and and CC cord-010119-t1x9gknd 10063 21 5 5 CD cord-010119-t1x9gknd 10063 22 days day NNS cord-010119-t1x9gknd 10063 23 post post NN cord-010119-t1x9gknd 10063 24 collection collection NN cord-010119-t1x9gknd 10063 25 . . . cord-010119-t1x9gknd 10064 1 The the DT cord-010119-t1x9gknd 10064 2 seeded seeded JJ cord-010119-t1x9gknd 10064 3 LRAP LRAP NNP cord-010119-t1x9gknd 10064 4 were be VBD cord-010119-t1x9gknd 10064 5 inoculated inoculate VBN cord-010119-t1x9gknd 10064 6 into into IN cord-010119-t1x9gknd 10064 7 BPA BPA NNP cord-010119-t1x9gknd 10064 8 and and CC cord-010119-t1x9gknd 10064 9 BPN BPN NNP cord-010119-t1x9gknd 10064 10 bottles bottle NNS cord-010119-t1x9gknd 10064 11 on on IN cord-010119-t1x9gknd 10064 12 10 10 CD cord-010119-t1x9gknd 10064 13 different different JJ cord-010119-t1x9gknd 10064 14 days day NNS cord-010119-t1x9gknd 10064 15 ( ( -LRB- cord-010119-t1x9gknd 10064 16 not not RB cord-010119-t1x9gknd 10064 17 consecutive consecutive JJ cord-010119-t1x9gknd 10064 18 ) ) -RRB- cord-010119-t1x9gknd 10064 19 alternating alternate VBG cord-010119-t1x9gknd 10064 20 between between IN cord-010119-t1x9gknd 10064 21 2 2 CD cord-010119-t1x9gknd 10064 22 teams team NNS cord-010119-t1x9gknd 10064 23 of of IN cord-010119-t1x9gknd 10064 24 2 2 CD cord-010119-t1x9gknd 10064 25 people people NNS cord-010119-t1x9gknd 10064 26 each each DT cord-010119-t1x9gknd 10064 27 . . . cord-010119-t1x9gknd 10065 1 Seeded seeded JJ cord-010119-t1x9gknd 10065 2 bottles bottle NNS cord-010119-t1x9gknd 10065 3 were be VBD cord-010119-t1x9gknd 10065 4 loaded load VBN cord-010119-t1x9gknd 10065 5 into into IN cord-010119-t1x9gknd 10065 6 a a DT cord-010119-t1x9gknd 10065 7 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 10065 8 and and CC cord-010119-t1x9gknd 10065 9 a a DT cord-010119-t1x9gknd 10065 10 BTA BTA NNP cord-010119-t1x9gknd 10065 11 3D 3d NN cord-010119-t1x9gknd 10065 12 and and CC cord-010119-t1x9gknd 10065 13 incubated incubate VBN cord-010119-t1x9gknd 10065 14 until until IN cord-010119-t1x9gknd 10065 15 declared declare VBN cord-010119-t1x9gknd 10065 16 positive positive JJ cord-010119-t1x9gknd 10065 17 or or CC cord-010119-t1x9gknd 10065 18 negative negative JJ cord-010119-t1x9gknd 10065 19 ( ( -LRB- cord-010119-t1x9gknd 10065 20 up up IN cord-010119-t1x9gknd 10065 21 to to TO cord-010119-t1x9gknd 10065 22 7 7 CD cord-010119-t1x9gknd 10065 23 days day NNS cord-010119-t1x9gknd 10065 24 ) ) -RRB- cord-010119-t1x9gknd 10065 25 . . . cord-010119-t1x9gknd 10066 1 Additionally additionally RB cord-010119-t1x9gknd 10066 2 , , , cord-010119-t1x9gknd 10066 3 BPA BPA NNP cord-010119-t1x9gknd 10066 4 and and CC cord-010119-t1x9gknd 10066 5 BPN BPN NNP cord-010119-t1x9gknd 10066 6 bottles bottle NNS cord-010119-t1x9gknd 10066 7 inoculated inoculate VBN cord-010119-t1x9gknd 10066 8 with with IN cord-010119-t1x9gknd 10066 9 4 4 CD cord-010119-t1x9gknd 10066 10 mL mL NNS cord-010119-t1x9gknd 10066 11 of of IN cord-010119-t1x9gknd 10066 12 unseeded unseeded JJ cord-010119-t1x9gknd 10066 13 LRAP LRAP NNP cord-010119-t1x9gknd 10066 14 were be VBD cord-010119-t1x9gknd 10066 15 tested test VBN cord-010119-t1x9gknd 10066 16 on on IN cord-010119-t1x9gknd 10066 17 the the DT cord-010119-t1x9gknd 10066 18 VIRTUO VIRTUO NNP cord-010119-t1x9gknd 10066 19 and and CC cord-010119-t1x9gknd 10066 20 the the DT cord-010119-t1x9gknd 10066 21 BTA BTA NNP cord-010119-t1x9gknd 10066 22 3D 3D NNP cord-010119-t1x9gknd 10066 23 ( ( -LRB- cord-010119-t1x9gknd 10066 24 120 120 CD cord-010119-t1x9gknd 10066 25 and and CC cord-010119-t1x9gknd 10066 26 40 40 CD cord-010119-t1x9gknd 10066 27 bottles bottle NNS cord-010119-t1x9gknd 10066 28 respectively respectively RB cord-010119-t1x9gknd 10066 29 ) ) -RRB- cord-010119-t1x9gknd 10066 30 , , , cord-010119-t1x9gknd 10066 31 to to TO cord-010119-t1x9gknd 10066 32 serve serve VB cord-010119-t1x9gknd 10066 33 as as IN cord-010119-t1x9gknd 10066 34 negative negative JJ cord-010119-t1x9gknd 10066 35 controls control NNS cord-010119-t1x9gknd 10066 36 , , , cord-010119-t1x9gknd 10066 37 sterility sterility NN cord-010119-t1x9gknd 10066 38 controls control NNS cord-010119-t1x9gknd 10066 39 , , , cord-010119-t1x9gknd 10066 40 and and CC cord-010119-t1x9gknd 10066 41 to to TO cord-010119-t1x9gknd 10066 42 evaluate evaluate VB cord-010119-t1x9gknd 10066 43 the the DT cord-010119-t1x9gknd 10066 44 risk risk NN cord-010119-t1x9gknd 10066 45 of of IN cord-010119-t1x9gknd 10066 46 false false JJ cord-010119-t1x9gknd 10066 47 positives positive NNS cord-010119-t1x9gknd 10066 48 caused cause VBN cord-010119-t1x9gknd 10066 49 by by IN cord-010119-t1x9gknd 10066 50 LRAP LRAP NNP cord-010119-t1x9gknd 10066 51 Results/ Results/ . cord-010119-t1x9gknd 10067 1 Finding finding NN cord-010119-t1x9gknd 10067 2 : : : cord-010119-t1x9gknd 10068 1 The the DT cord-010119-t1x9gknd 10068 2 repeatability repeatability NN cord-010119-t1x9gknd 10068 3 of of IN cord-010119-t1x9gknd 10068 4 the the DT cord-010119-t1x9gknd 10068 5 VIRTUO VIRTUO NNS cord-010119-t1x9gknd 10068 6 to to TO cord-010119-t1x9gknd 10068 7 detect detect VB cord-010119-t1x9gknd 10068 8 organisms organism NNS cord-010119-t1x9gknd 10068 9 in in IN cord-010119-t1x9gknd 10068 10 LRAP LRAP NNP cord-010119-t1x9gknd 10068 11 was be VBD cord-010119-t1x9gknd 10068 12 demonstrated demonstrate VBN cord-010119-t1x9gknd 10068 13 by by IN cord-010119-t1x9gknd 10068 14 a a DT cord-010119-t1x9gknd 10068 15 recovery recovery NN cord-010119-t1x9gknd 10068 16 rate rate NN cord-010119-t1x9gknd 10068 17 of of IN cord-010119-t1x9gknd 10068 18 seeded seeded JJ cord-010119-t1x9gknd 10068 19 bottles bottle NNS cord-010119-t1x9gknd 10068 20 of of IN cord-010119-t1x9gknd 10068 21 99.9 99.9 CD cord-010119-t1x9gknd 10068 22 % % NN cord-010119-t1x9gknd 10068 23 for for IN cord-010119-t1x9gknd 10068 24 the the DT cord-010119-t1x9gknd 10068 25 VIRTUO VIRTUO NNS cord-010119-t1x9gknd 10068 26 and and CC cord-010119-t1x9gknd 10068 27 99.5 99.5 CD cord-010119-t1x9gknd 10068 28 % % NN cord-010119-t1x9gknd 10068 29 for for IN cord-010119-t1x9gknd 10068 30 the the DT cord-010119-t1x9gknd 10068 31 BTA BTA NNP cord-010119-t1x9gknd 10068 32 3D. 3d. CD cord-010119-t1x9gknd 10069 1 The the DT cord-010119-t1x9gknd 10069 2 VIRTUO VIRTUO NNS cord-010119-t1x9gknd 10069 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 10069 4 an an DT cord-010119-t1x9gknd 10069 5 average average NN cord-010119-t1x9gknd 10069 6 improved improve VBN cord-010119-t1x9gknd 10069 7 TTD TTD NNP cord-010119-t1x9gknd 10069 8 of of IN cord-010119-t1x9gknd 10069 9 3.2 3.2 CD cord-010119-t1x9gknd 10069 10 hours hour NNS cord-010119-t1x9gknd 10069 11 , , , cord-010119-t1x9gknd 10069 12 when when WRB cord-010119-t1x9gknd 10069 13 compared compare VBN cord-010119-t1x9gknd 10069 14 to to IN cord-010119-t1x9gknd 10069 15 the the DT cord-010119-t1x9gknd 10069 16 BTA BTA NNP cord-010119-t1x9gknd 10069 17 3D 3d NN cord-010119-t1x9gknd 10069 18 in in IN cord-010119-t1x9gknd 10069 19 the the DT cord-010119-t1x9gknd 10069 20 presence presence NN cord-010119-t1x9gknd 10069 21 of of IN cord-010119-t1x9gknd 10069 22 4 4 CD cord-010119-t1x9gknd 10069 23 mL ml NN cord-010119-t1x9gknd 10069 24 LRAP LRAP NNP cord-010119-t1x9gknd 10069 25 platelets platelet NNS cord-010119-t1x9gknd 10069 26 . . . cord-010119-t1x9gknd 10070 1 The the DT cord-010119-t1x9gknd 10070 2 LRAP LRAP NNP cord-010119-t1x9gknd 10070 3 did do VBD cord-010119-t1x9gknd 10070 4 not not RB cord-010119-t1x9gknd 10070 5 cause cause VB cord-010119-t1x9gknd 10070 6 false false JJ cord-010119-t1x9gknd 10070 7 positives positive NNS cord-010119-t1x9gknd 10070 8 . . . cord-010119-t1x9gknd 10071 1 Additionally additionally RB cord-010119-t1x9gknd 10071 2 , , , cord-010119-t1x9gknd 10071 3 the the DT cord-010119-t1x9gknd 10071 4 age age NN cord-010119-t1x9gknd 10071 5 of of IN cord-010119-t1x9gknd 10071 6 the the DT cord-010119-t1x9gknd 10071 7 LRAP LRAP NNP cord-010119-t1x9gknd 10071 8 units unit NNS cord-010119-t1x9gknd 10071 9 ( ( -LRB- cord-010119-t1x9gknd 10071 10 within within IN cord-010119-t1x9gknd 10071 11 5 5 CD cord-010119-t1x9gknd 10071 12 day day NN cord-010119-t1x9gknd 10071 13 expiry),did expiry),did NNP cord-010119-t1x9gknd 10071 14 not not RB cord-010119-t1x9gknd 10071 15 impact impact VB cord-010119-t1x9gknd 10071 16 the the DT cord-010119-t1x9gknd 10071 17 TTD ttd NN cord-010119-t1x9gknd 10071 18 when when WRB cord-010119-t1x9gknd 10071 19 seeded seed VBN cord-010119-t1x9gknd 10071 20 with with IN cord-010119-t1x9gknd 10071 21 organism organism NN cord-010119-t1x9gknd 10071 22 Background Background NNP cord-010119-t1x9gknd 10071 23 / / SYM cord-010119-t1x9gknd 10071 24 Case Case NNP cord-010119-t1x9gknd 10071 25 Studies Studies NNPS cord-010119-t1x9gknd 10071 26 : : : cord-010119-t1x9gknd 10072 1 Zika Zika NNP cord-010119-t1x9gknd 10072 2 Virus Virus NNP cord-010119-t1x9gknd 10072 3 ( ( -LRB- cord-010119-t1x9gknd 10072 4 ZIKV ZIKV NNP cord-010119-t1x9gknd 10072 5 ) ) -RRB- cord-010119-t1x9gknd 10072 6 is be VBZ cord-010119-t1x9gknd 10072 7 an an DT cord-010119-t1x9gknd 10072 8 emerging emerge VBG cord-010119-t1x9gknd 10072 9 flavivirus flavivirus NN cord-010119-t1x9gknd 10072 10 that that WDT cord-010119-t1x9gknd 10072 11 is be VBZ cord-010119-t1x9gknd 10072 12 transmitted transmit VBN cord-010119-t1x9gknd 10072 13 by by IN cord-010119-t1x9gknd 10072 14 the the DT cord-010119-t1x9gknd 10072 15 Aedes Aedes NNP cord-010119-t1x9gknd 10072 16 aegypti aegypti NN cord-010119-t1x9gknd 10072 17 mosquito mosquito NN cord-010119-t1x9gknd 10072 18 and and CC cord-010119-t1x9gknd 10072 19 sometimes sometimes RB cord-010119-t1x9gknd 10072 20 A. A. NNP cord-010119-t1x9gknd 10072 21 albopictus albopictus FW cord-010119-t1x9gknd 10072 22 mosquito mosquito NN cord-010119-t1x9gknd 10072 23 . . . cord-010119-t1x9gknd 10073 1 Most Most JJS cord-010119-t1x9gknd 10073 2 infections infection NNS cord-010119-t1x9gknd 10073 3 are be VBP cord-010119-t1x9gknd 10073 4 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 10073 5 . . . cord-010119-t1x9gknd 10074 1 ZIKV ZIKV NNP cord-010119-t1x9gknd 10074 2 Nucleic Nucleic NNP cord-010119-t1x9gknd 10074 3 Acid acid NN cord-010119-t1x9gknd 10074 4 Testing Testing NNP cord-010119-t1x9gknd 10074 5 ( ( -LRB- cord-010119-t1x9gknd 10074 6 NAT NAT NNP cord-010119-t1x9gknd 10074 7 ) ) -RRB- cord-010119-t1x9gknd 10074 8 became become VBD cord-010119-t1x9gknd 10074 9 a a DT cord-010119-t1x9gknd 10074 10 required required JJ cord-010119-t1x9gknd 10074 11 test test NN cord-010119-t1x9gknd 10074 12 for for IN cord-010119-t1x9gknd 10074 13 blood blood NN cord-010119-t1x9gknd 10074 14 donors donor NNS cord-010119-t1x9gknd 10074 15 per per IN cord-010119-t1x9gknd 10074 16 the the DT cord-010119-t1x9gknd 10074 17 FDA FDA NNP cord-010119-t1x9gknd 10074 18 Guidance Guidance NNP cord-010119-t1x9gknd 10074 19 entitled entitle VBN cord-010119-t1x9gknd 10074 20 , , , cord-010119-t1x9gknd 10074 21 " " `` cord-010119-t1x9gknd 10074 22 Revised Revised NNP cord-010119-t1x9gknd 10074 23 Recommendations Recommendations NNPS cord-010119-t1x9gknd 10074 24 for for IN cord-010119-t1x9gknd 10074 25 Reducing reduce VBG cord-010119-t1x9gknd 10074 26 the the DT cord-010119-t1x9gknd 10074 27 Risk Risk NNP cord-010119-t1x9gknd 10074 28 of of IN cord-010119-t1x9gknd 10074 29 Zika Zika NNP cord-010119-t1x9gknd 10074 30 Virus Virus NNP cord-010119-t1x9gknd 10074 31 Transmission Transmission NNP cord-010119-t1x9gknd 10074 32 by by IN cord-010119-t1x9gknd 10074 33 Blood blood NN cord-010119-t1x9gknd 10074 34 and and CC cord-010119-t1x9gknd 10074 35 Blood blood NN cord-010119-t1x9gknd 10074 36 Components Components NNP cord-010119-t1x9gknd 10074 37 " " '' cord-010119-t1x9gknd 10074 38 . . . cord-010119-t1x9gknd 10075 1 Based base VBN cord-010119-t1x9gknd 10075 2 on on IN cord-010119-t1x9gknd 10075 3 our -PRON- PRP$ cord-010119-t1x9gknd 10075 4 geographical geographical JJ cord-010119-t1x9gknd 10075 5 location location NN cord-010119-t1x9gknd 10075 6 , , , cord-010119-t1x9gknd 10075 7 implementation implementation NN cord-010119-t1x9gknd 10075 8 of of IN cord-010119-t1x9gknd 10075 9 this this DT cord-010119-t1x9gknd 10075 10 testing testing NN cord-010119-t1x9gknd 10075 11 began begin VBD cord-010119-t1x9gknd 10075 12 12 12 CD cord-010119-t1x9gknd 10075 13 weeks week NNS cord-010119-t1x9gknd 10075 14 after after IN cord-010119-t1x9gknd 10075 15 this this DT cord-010119-t1x9gknd 10075 16 guidance guidance NN cord-010119-t1x9gknd 10075 17 was be VBD cord-010119-t1x9gknd 10075 18 issued issue VBN cord-010119-t1x9gknd 10075 19 . . . cord-010119-t1x9gknd 10076 1 We -PRON- PRP cord-010119-t1x9gknd 10076 2 performed perform VBD cord-010119-t1x9gknd 10076 3 ZIKV ZIKV NNP cord-010119-t1x9gknd 10076 4 NAT NAT NNP cord-010119-t1x9gknd 10076 5 for for IN cord-010119-t1x9gknd 10076 6 donors donor NNS cord-010119-t1x9gknd 10076 7 of of IN cord-010119-t1x9gknd 10076 8 whole whole JJ cord-010119-t1x9gknd 10076 9 blood blood NN cord-010119-t1x9gknd 10076 10 and and CC cord-010119-t1x9gknd 10076 11 blood blood NN cord-010119-t1x9gknd 10076 12 components component NNS cord-010119-t1x9gknd 10076 13 under under IN cord-010119-t1x9gknd 10076 14 an an DT cord-010119-t1x9gknd 10076 15 Investigational Investigational NNP cord-010119-t1x9gknd 10076 16 New New NNP cord-010119-t1x9gknd 10076 17 Drug Drug NNP cord-010119-t1x9gknd 10076 18 ( ( -LRB- cord-010119-t1x9gknd 10076 19 IND IND NNP cord-010119-t1x9gknd 10076 20 ) ) -RRB- cord-010119-t1x9gknd 10076 21 Study Study NNP cord-010119-t1x9gknd 10076 22 ( ( -LRB- cord-010119-t1x9gknd 10076 23 sponsored sponsor VBN cord-010119-t1x9gknd 10076 24 by by IN cord-010119-t1x9gknd 10076 25 Hologic Hologic NNP cord-010119-t1x9gknd 10076 26 , , , cord-010119-t1x9gknd 10076 27 Inc. Inc. NNP cord-010119-t1x9gknd 10076 28 ) ) -RRB- cord-010119-t1x9gknd 10076 29 . . . cord-010119-t1x9gknd 10077 1 We -PRON- PRP cord-010119-t1x9gknd 10077 2 performed perform VBD cord-010119-t1x9gknd 10077 3 a a DT cord-010119-t1x9gknd 10077 4 retrospective retrospective JJ cord-010119-t1x9gknd 10077 5 analysis analysis NN cord-010119-t1x9gknd 10077 6 on on IN cord-010119-t1x9gknd 10077 7 all all DT cord-010119-t1x9gknd 10077 8 NAT NAT NNP cord-010119-t1x9gknd 10077 9 results result NNS cord-010119-t1x9gknd 10077 10 as as IN cord-010119-t1x9gknd 10077 11 there there EX cord-010119-t1x9gknd 10077 12 is be VBZ cord-010119-t1x9gknd 10077 13 a a DT cord-010119-t1x9gknd 10077 14 potential potential NN cord-010119-t1x9gknd 10077 15 to to TO cord-010119-t1x9gknd 10077 16 defer defer VB cord-010119-t1x9gknd 10077 17 donation donation NN cord-010119-t1x9gknd 10077 18 due due JJ cord-010119-t1x9gknd 10077 19 to to IN cord-010119-t1x9gknd 10077 20 false false JJ cord-010119-t1x9gknd 10077 21 positive positive JJ cord-010119-t1x9gknd 10077 22 screening screening NN cord-010119-t1x9gknd 10077 23 results result NNS cord-010119-t1x9gknd 10077 24 . . . cord-010119-t1x9gknd 10078 1 Study Study NNP cord-010119-t1x9gknd 10078 2 Design Design NNP cord-010119-t1x9gknd 10078 3 / / SYM cord-010119-t1x9gknd 10078 4 Method method NN cord-010119-t1x9gknd 10078 5 : : : cord-010119-t1x9gknd 10078 6 Donors donor NNS cord-010119-t1x9gknd 10078 7 that that WDT cord-010119-t1x9gknd 10078 8 consented consent VBD cord-010119-t1x9gknd 10078 9 to to TO cord-010119-t1x9gknd 10078 10 donate donate VB cord-010119-t1x9gknd 10078 11 blood blood NN cord-010119-t1x9gknd 10078 12 and and CC cord-010119-t1x9gknd 10078 13 be be VB cord-010119-t1x9gknd 10078 14 tested test VBN cord-010119-t1x9gknd 10078 15 for for IN cord-010119-t1x9gknd 10078 16 the the DT cord-010119-t1x9gknd 10078 17 ZIKV ZIKV NNP cord-010119-t1x9gknd 10078 18 were be VBD cord-010119-t1x9gknd 10078 19 obtained obtain VBN cord-010119-t1x9gknd 10078 20 from from IN cord-010119-t1x9gknd 10078 21 three three CD cord-010119-t1x9gknd 10078 22 Blood Blood NNP cord-010119-t1x9gknd 10078 23 Banks Banks NNPS cord-010119-t1x9gknd 10078 24 in in IN cord-010119-t1x9gknd 10078 25 Colorado Colorado NNP cord-010119-t1x9gknd 10078 26 and and CC cord-010119-t1x9gknd 10078 27 Nebraska Nebraska NNP cord-010119-t1x9gknd 10078 28 . . . cord-010119-t1x9gknd 10079 1 NAT NAT NNP cord-010119-t1x9gknd 10079 2 was be VBD cord-010119-t1x9gknd 10079 3 performed perform VBN cord-010119-t1x9gknd 10079 4 using use VBG cord-010119-t1x9gknd 10079 5 the the DT cord-010119-t1x9gknd 10079 6 Procleix Procleix NNP cord-010119-t1x9gknd 10079 7 Virus Virus NNP cord-010119-t1x9gknd 10079 8 assay assay NN cord-010119-t1x9gknd 10079 9 which which WDT cord-010119-t1x9gknd 10079 10 is be VBZ cord-010119-t1x9gknd 10079 11 a a DT cord-010119-t1x9gknd 10079 12 qualitative qualitative JJ cord-010119-t1x9gknd 10079 13 in in IN cord-010119-t1x9gknd 10079 14 vitro vitro FW cord-010119-t1x9gknd 10079 15 nucleic nucleic JJ cord-010119-t1x9gknd 10079 16 acid acid NN cord-010119-t1x9gknd 10079 17 assay assay NN cord-010119-t1x9gknd 10079 18 system system NN cord-010119-t1x9gknd 10079 19 that that WDT cord-010119-t1x9gknd 10079 20 detects detect VBZ cord-010119-t1x9gknd 10079 21 ZIKV ZIKV NNP cord-010119-t1x9gknd 10079 22 RNA RNA NNP cord-010119-t1x9gknd 10079 23 in in IN cord-010119-t1x9gknd 10079 24 plasma plasma NN cord-010119-t1x9gknd 10079 25 specimens specimen NNS cord-010119-t1x9gknd 10079 26 . . . cord-010119-t1x9gknd 10080 1 The the DT cord-010119-t1x9gknd 10080 2 assay assay NN cord-010119-t1x9gknd 10080 3 was be VBD cord-010119-t1x9gknd 10080 4 performed perform VBN cord-010119-t1x9gknd 10080 5 on on IN cord-010119-t1x9gknd 10080 6 the the DT cord-010119-t1x9gknd 10080 7 automated automate VBN cord-010119-t1x9gknd 10080 8 Procleix Procleix NNP cord-010119-t1x9gknd 10080 9 Panther Panther NNP cord-010119-t1x9gknd 10080 10 system system NN cord-010119-t1x9gknd 10080 11 . . . cord-010119-t1x9gknd 10081 1 All all DT cord-010119-t1x9gknd 10081 2 testing testing NN cord-010119-t1x9gknd 10081 3 was be VBD cord-010119-t1x9gknd 10081 4 performed perform VBN cord-010119-t1x9gknd 10081 5 according accord VBG cord-010119-t1x9gknd 10081 6 to to IN cord-010119-t1x9gknd 10081 7 the the DT cord-010119-t1x9gknd 10081 8 manufacturer manufacturer NN cord-010119-t1x9gknd 10081 9 package package NN cord-010119-t1x9gknd 10081 10 insert insert NN cord-010119-t1x9gknd 10081 11 . . . cord-010119-t1x9gknd 10082 1 Results result NNS cord-010119-t1x9gknd 10082 2 / / SYM cord-010119-t1x9gknd 10082 3 Findings finding NNS cord-010119-t1x9gknd 10082 4 : : : cord-010119-t1x9gknd 10083 1 In in IN cord-010119-t1x9gknd 10083 2 the the DT cord-010119-t1x9gknd 10083 3 event event NN cord-010119-t1x9gknd 10083 4 of of IN cord-010119-t1x9gknd 10083 5 a a DT cord-010119-t1x9gknd 10083 6 Reactive reactive JJ cord-010119-t1x9gknd 10083 7 result result NN cord-010119-t1x9gknd 10083 8 , , , cord-010119-t1x9gknd 10083 9 donors donor NNS cord-010119-t1x9gknd 10083 10 would would MD cord-010119-t1x9gknd 10083 11 be be VB cord-010119-t1x9gknd 10083 12 retested reteste VBN cord-010119-t1x9gknd 10083 13 by by IN cord-010119-t1x9gknd 10083 14 NAT NAT NNP cord-010119-t1x9gknd 10083 15 in in IN cord-010119-t1x9gknd 10083 16 addition addition NN cord-010119-t1x9gknd 10083 17 to to IN cord-010119-t1x9gknd 10083 18 other other JJ cord-010119-t1x9gknd 10083 19 testing testing NN cord-010119-t1x9gknd 10083 20 ( ( -LRB- cord-010119-t1x9gknd 10083 21 IgM IgM NNP cord-010119-t1x9gknd 10083 22 antibody antibody NNP cord-010119-t1x9gknd 10083 23 testing testing NN cord-010119-t1x9gknd 10083 24 , , , cord-010119-t1x9gknd 10083 25 neutralization neutralization NN cord-010119-t1x9gknd 10083 26 test test NN cord-010119-t1x9gknd 10083 27 ) ) -RRB- cord-010119-t1x9gknd 10083 28 . . . cord-010119-t1x9gknd 10084 1 Donors donor NNS cord-010119-t1x9gknd 10084 2 are be VBP cord-010119-t1x9gknd 10084 3 deferred defer VBN cord-010119-t1x9gknd 10084 4 for for IN cord-010119-t1x9gknd 10084 5 120 120 CD cord-010119-t1x9gknd 10084 6 days day NNS cord-010119-t1x9gknd 10084 7 barring bar VBG cord-010119-t1x9gknd 10084 8 continued continue VBD cord-010119-t1x9gknd 10084 9 ZIKV ZIKV NNP cord-010119-t1x9gknd 10084 10 testing testing NN cord-010119-t1x9gknd 10084 11 and and CC cord-010119-t1x9gknd 10084 12 NonReactive NonReactive NNP cord-010119-t1x9gknd 10084 13 results result NNS cord-010119-t1x9gknd 10084 14 . . . cord-010119-t1x9gknd 10085 1 A a DT cord-010119-t1x9gknd 10085 2 total total NN cord-010119-t1x9gknd 10085 3 of of IN cord-010119-t1x9gknd 10085 4 2,485 2,485 CD cord-010119-t1x9gknd 10085 5 donors donor NNS cord-010119-t1x9gknd 10085 6 were be VBD cord-010119-t1x9gknd 10085 7 screened screen VBN cord-010119-t1x9gknd 10085 8 for for IN cord-010119-t1x9gknd 10085 9 ZIKV ZIKV NNP cord-010119-t1x9gknd 10085 10 . . . cord-010119-t1x9gknd 10086 1 All all DT cord-010119-t1x9gknd 10086 2 donors donor NNS cord-010119-t1x9gknd 10086 3 screened screen VBN cord-010119-t1x9gknd 10086 4 for for IN cord-010119-t1x9gknd 10086 5 ZIKV ZIKV NNP cord-010119-t1x9gknd 10086 6 were be VBD cord-010119-t1x9gknd 10086 7 NonReactive NonReactive NNP cord-010119-t1x9gknd 10086 8 by by IN cord-010119-t1x9gknd 10086 9 NAT NAT NNP cord-010119-t1x9gknd 10086 10 . . . cord-010119-t1x9gknd 10087 1 No no DT cord-010119-t1x9gknd 10087 2 invalid invalid JJ cord-010119-t1x9gknd 10087 3 test test NN cord-010119-t1x9gknd 10087 4 results result NNS cord-010119-t1x9gknd 10087 5 were be VBD cord-010119-t1x9gknd 10087 6 obtained obtain VBN cord-010119-t1x9gknd 10087 7 . . . cord-010119-t1x9gknd 10088 1 In in IN cord-010119-t1x9gknd 10088 2 addition addition NN cord-010119-t1x9gknd 10088 3 the the DT cord-010119-t1x9gknd 10088 4 number number NN cord-010119-t1x9gknd 10088 5 of of IN cord-010119-t1x9gknd 10088 6 failed fail VBN cord-010119-t1x9gknd 10088 7 test test NN cord-010119-t1x9gknd 10088 8 runs run NNS cord-010119-t1x9gknd 10088 9 due due IN cord-010119-t1x9gknd 10088 10 to to IN cord-010119-t1x9gknd 10088 11 instrument instrument NN cord-010119-t1x9gknd 10088 12 or or CC cord-010119-t1x9gknd 10088 13 assay assay NN cord-010119-t1x9gknd 10088 14 issues issue NNS cord-010119-t1x9gknd 10088 15 were be VBD cord-010119-t1x9gknd 10088 16 experienced experience VBN cord-010119-t1x9gknd 10088 17 were be VBD cord-010119-t1x9gknd 10088 18 quite quite RB cord-010119-t1x9gknd 10088 19 low low JJ cord-010119-t1x9gknd 10088 20 ( ( -LRB- cord-010119-t1x9gknd 10088 21 1.0 1.0 CD cord-010119-t1x9gknd 10088 22 % % NN cord-010119-t1x9gknd 10088 23 ) ) -RRB- cord-010119-t1x9gknd 10088 24 . . . cord-010119-t1x9gknd 10089 1 This this DT cord-010119-t1x9gknd 10089 2 data data NN cord-010119-t1x9gknd 10089 3 indicates indicate VBZ cord-010119-t1x9gknd 10089 4 that that IN cord-010119-t1x9gknd 10089 5 both both CC cord-010119-t1x9gknd 10089 6 the the DT cord-010119-t1x9gknd 10089 7 assay assay NN cord-010119-t1x9gknd 10089 8 and and CC cord-010119-t1x9gknd 10089 9 instrument instrument NN cord-010119-t1x9gknd 10089 10 are be VBP cord-010119-t1x9gknd 10089 11 robust robust JJ cord-010119-t1x9gknd 10089 12 . . . cord-010119-t1x9gknd 10090 1 There there EX cord-010119-t1x9gknd 10090 2 was be VBD cord-010119-t1x9gknd 10090 3 a a DT cord-010119-t1x9gknd 10090 4 low low JJ cord-010119-t1x9gknd 10090 5 frequency frequency NN cord-010119-t1x9gknd 10090 6 for for IN cord-010119-t1x9gknd 10090 7 additional additional JJ cord-010119-t1x9gknd 10090 8 testing testing NN cord-010119-t1x9gknd 10090 9 which which WDT cord-010119-t1x9gknd 10090 10 allows allow VBZ cord-010119-t1x9gknd 10090 11 the the DT cord-010119-t1x9gknd 10090 12 laboratory laboratory NN cord-010119-t1x9gknd 10090 13 to to TO cord-010119-t1x9gknd 10090 14 publish publish VB cord-010119-t1x9gknd 10090 15 timely timely JJ cord-010119-t1x9gknd 10090 16 infectious infectious JJ cord-010119-t1x9gknd 10090 17 disease disease NN cord-010119-t1x9gknd 10090 18 results result NNS cord-010119-t1x9gknd 10090 19 for for IN cord-010119-t1x9gknd 10090 20 our -PRON- PRP$ cord-010119-t1x9gknd 10090 21 Blood Blood NNP cord-010119-t1x9gknd 10090 22 Bank Bank NNP cord-010119-t1x9gknd 10090 23 customers customer NNS cord-010119-t1x9gknd 10090 24 . . . cord-010119-t1x9gknd 10091 1 Conclusion conclusion NN cord-010119-t1x9gknd 10091 2 : : : cord-010119-t1x9gknd 10092 1 The the DT cord-010119-t1x9gknd 10092 2 reactive reactive JJ cord-010119-t1x9gknd 10092 3 rate rate NN cord-010119-t1x9gknd 10092 4 data datum NNS cord-010119-t1x9gknd 10092 5 presented present VBN cord-010119-t1x9gknd 10092 6 here here RB cord-010119-t1x9gknd 10092 7 demonstrate demonstrate VBP cord-010119-t1x9gknd 10092 8 that that IN cord-010119-t1x9gknd 10092 9 there there EX cord-010119-t1x9gknd 10092 10 is be VBZ cord-010119-t1x9gknd 10092 11 a a DT cord-010119-t1x9gknd 10092 12 low low JJ cord-010119-t1x9gknd 10092 13 / / SYM cord-010119-t1x9gknd 10092 14 zero zero CD cord-010119-t1x9gknd 10092 15 incident incident NN cord-010119-t1x9gknd 10092 16 rate rate NN cord-010119-t1x9gknd 10092 17 in in IN cord-010119-t1x9gknd 10092 18 our -PRON- PRP$ cord-010119-t1x9gknd 10092 19 region region NN cord-010119-t1x9gknd 10092 20 for for IN cord-010119-t1x9gknd 10092 21 whole whole JJ cord-010119-t1x9gknd 10092 22 blood blood NN cord-010119-t1x9gknd 10092 23 and and CC cord-010119-t1x9gknd 10092 24 blood blood NN cord-010119-t1x9gknd 10092 25 component component NN cord-010119-t1x9gknd 10092 26 discard discard VBP cord-010119-t1x9gknd 10092 27 due due IN cord-010119-t1x9gknd 10092 28 to to IN cord-010119-t1x9gknd 10092 29 reactive reactive JJ cord-010119-t1x9gknd 10092 30 results result NNS cord-010119-t1x9gknd 10092 31 . . . cord-010119-t1x9gknd 10093 1 This this DT cord-010119-t1x9gknd 10093 2 screening screening NN cord-010119-t1x9gknd 10093 3 is be VBZ cord-010119-t1x9gknd 10093 4 important important JJ cord-010119-t1x9gknd 10093 5 to to TO cord-010119-t1x9gknd 10093 6 continue continue VB cord-010119-t1x9gknd 10093 7 to to TO cord-010119-t1x9gknd 10093 8 ensure ensure VB cord-010119-t1x9gknd 10093 9 blood blood NN cord-010119-t1x9gknd 10093 10 safety safety NN cord-010119-t1x9gknd 10093 11 in in IN cord-010119-t1x9gknd 10093 12 the the DT cord-010119-t1x9gknd 10093 13 United United NNP cord-010119-t1x9gknd 10093 14 States States NNP cord-010119-t1x9gknd 10093 15 . . . cord-010119-t1x9gknd 10094 1 Robust Robust NNP cord-010119-t1x9gknd 10094 2 Inactivation Inactivation NNP cord-010119-t1x9gknd 10094 3 of of IN cord-010119-t1x9gknd 10094 4 the the DT cord-010119-t1x9gknd 10094 5 Yellow Yellow NNP cord-010119-t1x9gknd 10094 6 Fever Fever NNP cord-010119-t1x9gknd 10094 7 Virus Virus NNP cord-010119-t1x9gknd 10094 8 17D 17d NN cord-010119-t1x9gknd 10094 9 Strain strain NN cord-010119-t1x9gknd 10094 10 Can Can MD cord-010119-t1x9gknd 10094 11 be be VB cord-010119-t1x9gknd 10094 12 Achieved achieve VBN cord-010119-t1x9gknd 10094 13 Using use VBG cord-010119-t1x9gknd 10094 14 Amotosalen Amotosalen NNP cord-010119-t1x9gknd 10094 15 and and CC cord-010119-t1x9gknd 10094 16 UVA UVA NNP cord-010119-t1x9gknd 10094 17 Light Light NNP cord-010119-t1x9gknd 10094 18 for for IN cord-010119-t1x9gknd 10094 19 Pathogen Pathogen NNP cord-010119-t1x9gknd 10094 20 Reduction Reduction NNP cord-010119-t1x9gknd 10094 21 Treatment Treatment NNP cord-010119-t1x9gknd 10094 22 ( ( -LRB- cord-010119-t1x9gknd 10094 23 PRT PRT NNP cord-010119-t1x9gknd 10094 24 ) ) -RRB- cord-010119-t1x9gknd 10094 25 of of IN cord-010119-t1x9gknd 10094 26 Platelet platelet NN cord-010119-t1x9gknd 10094 27 Components Components NNP cord-010119-t1x9gknd 10094 28 Andrew Andrew NNP cord-010119-t1x9gknd 10094 29 Laughhunn Laughhunn NNP cord-010119-t1x9gknd 10094 30 1 1 CD cord-010119-t1x9gknd 10094 31 , , , cord-010119-t1x9gknd 10094 32 Felicia Felicia NNP cord-010119-t1x9gknd 10094 33 Santa Santa NNP cord-010119-t1x9gknd 10094 34 Maria Maria NNP cord-010119-t1x9gknd 10094 35 1 1 CD cord-010119-t1x9gknd 10094 36 , , , cord-010119-t1x9gknd 10094 37 Yvette Yvette NNP cord-010119-t1x9gknd 10094 38 Girard Girard NNP cord-010119-t1x9gknd 10094 39 1 1 CD cord-010119-t1x9gknd 10094 40 , , , cord-010119-t1x9gknd 10094 41 Peter Peter NNP cord-010119-t1x9gknd 10094 42 Bringmann Bringmann NNP cord-010119-t1x9gknd 10094 43 1 1 CD cord-010119-t1x9gknd 10094 44 , , , cord-010119-t1x9gknd 10094 45 Marion Marion NNP cord-010119-t1x9gknd 10094 46 Lanteri Lanteri NNP cord-010119-t1x9gknd 10094 47 * * NFP cord-010119-t1x9gknd 10094 48 2 2 CD cord-010119-t1x9gknd 10094 49 and and CC cord-010119-t1x9gknd 10094 50 Adonis Adonis NNP cord-010119-t1x9gknd 10094 51 Stassinopoulos Stassinopoulos NNP cord-010119-t1x9gknd 10094 52 2 2 CD cord-010119-t1x9gknd 10094 53 . . . cord-010119-t1x9gknd 10095 1 1 1 CD cord-010119-t1x9gknd 10095 2 Microbiology Microbiology NNP cord-010119-t1x9gknd 10095 3 Department Department NNP cord-010119-t1x9gknd 10095 4 , , , cord-010119-t1x9gknd 10095 5 Cerus Cerus NNP cord-010119-t1x9gknd 10095 6 Corporation Corporation NNP cord-010119-t1x9gknd 10095 7 , , , cord-010119-t1x9gknd 10095 8 2 2 CD cord-010119-t1x9gknd 10095 9 Scientific Scientific NNP cord-010119-t1x9gknd 10095 10 Affairs Affairs NNPS cord-010119-t1x9gknd 10095 11 Department Department NNP cord-010119-t1x9gknd 10095 12 , , , cord-010119-t1x9gknd 10095 13 Cerus Cerus NNP cord-010119-t1x9gknd 10095 14 Corporation Corporation NNP cord-010119-t1x9gknd 10095 15 Background Background NNP cord-010119-t1x9gknd 10095 16 / / SYM cord-010119-t1x9gknd 10095 17 Case Case NNP cord-010119-t1x9gknd 10095 18 Studies Studies NNPS cord-010119-t1x9gknd 10095 19 : : : cord-010119-t1x9gknd 10095 20 Yellow yellow JJ cord-010119-t1x9gknd 10095 21 fever fever NN cord-010119-t1x9gknd 10095 22 virus virus NN cord-010119-t1x9gknd 10095 23 ( ( -LRB- cord-010119-t1x9gknd 10095 24 YFV YFV NNP cord-010119-t1x9gknd 10095 25 ) ) -RRB- cord-010119-t1x9gknd 10095 26 is be VBZ cord-010119-t1x9gknd 10095 27 known know VBN cord-010119-t1x9gknd 10095 28 to to TO cord-010119-t1x9gknd 10095 29 cause cause VB cord-010119-t1x9gknd 10095 30 explosive explosive JJ cord-010119-t1x9gknd 10095 31 outbreaks outbreak NNS cord-010119-t1x9gknd 10095 32 , , , cord-010119-t1x9gknd 10095 33 such such JJ cord-010119-t1x9gknd 10095 34 as as IN cord-010119-t1x9gknd 10095 35 the the DT cord-010119-t1x9gknd 10095 36 one one CD cord-010119-t1x9gknd 10095 37 in in IN cord-010119-t1x9gknd 10095 38 Angola Angola NNP cord-010119-t1x9gknd 10095 39 in in IN cord-010119-t1x9gknd 10095 40 2015 2015 CD cord-010119-t1x9gknd 10095 41 . . . cord-010119-t1x9gknd 10096 1 The the DT cord-010119-t1x9gknd 10096 2 rapidly rapidly RB cord-010119-t1x9gknd 10096 3 increasing increase VBG cord-010119-t1x9gknd 10096 4 number number NN cord-010119-t1x9gknd 10096 5 of of IN cord-010119-t1x9gknd 10096 6 infections infection NNS cord-010119-t1x9gknd 10096 7 in in IN cord-010119-t1x9gknd 10096 8 Brazil Brazil NNP cord-010119-t1x9gknd 10096 9 , , , cord-010119-t1x9gknd 10096 10 with with IN cord-010119-t1x9gknd 10096 11 hundreds hundred NNS cord-010119-t1x9gknd 10096 12 of of IN cord-010119-t1x9gknd 10096 13 fatalities fatality NNS cord-010119-t1x9gknd 10096 14 since since IN cord-010119-t1x9gknd 10096 15 December December NNP cord-010119-t1x9gknd 10096 16 2016 2016 CD cord-010119-t1x9gknd 10096 17 , , , cord-010119-t1x9gknd 10096 18 is be VBZ cord-010119-t1x9gknd 10096 19 of of IN cord-010119-t1x9gknd 10096 20 concern concern NN cord-010119-t1x9gknd 10096 21 . . . cord-010119-t1x9gknd 10097 1 YFV YFV NNP cord-010119-t1x9gknd 10097 2 is be VBZ cord-010119-t1x9gknd 10097 3 a a DT cord-010119-t1x9gknd 10097 4 Flavivirus Flavivirus NNP cord-010119-t1x9gknd 10097 5 transmitted transmit VBN cord-010119-t1x9gknd 10097 6 by by IN cord-010119-t1x9gknd 10097 7 Aedes Aedes NNP cord-010119-t1x9gknd 10097 8 mosquitoes mosquito NNS cord-010119-t1x9gknd 10097 9 and and CC cord-010119-t1x9gknd 10097 10 could could MD cord-010119-t1x9gknd 10097 11 spread spread VB cord-010119-t1x9gknd 10097 12 , , , cord-010119-t1x9gknd 10097 13 like like IN cord-010119-t1x9gknd 10097 14 Zika Zika NNP cord-010119-t1x9gknd 10097 15 virus virus NN cord-010119-t1x9gknd 10097 16 , , , cord-010119-t1x9gknd 10097 17 to to IN cord-010119-t1x9gknd 10097 18 other other JJ cord-010119-t1x9gknd 10097 19 parts part NNS cord-010119-t1x9gknd 10097 20 of of IN cord-010119-t1x9gknd 10097 21 the the DT cord-010119-t1x9gknd 10097 22 Americas Americas NNPS cord-010119-t1x9gknd 10097 23 where where WRB cord-010119-t1x9gknd 10097 24 the the DT cord-010119-t1x9gknd 10097 25 vector vector NN cord-010119-t1x9gknd 10097 26 is be VBZ cord-010119-t1x9gknd 10097 27 endemic endemic JJ cord-010119-t1x9gknd 10097 28 . . . cord-010119-t1x9gknd 10098 1 With with IN cord-010119-t1x9gknd 10098 2 no no DT cord-010119-t1x9gknd 10098 3 effective effective JJ cord-010119-t1x9gknd 10098 4 antivirals antiviral NNS cord-010119-t1x9gknd 10098 5 and and CC cord-010119-t1x9gknd 10098 6 only only RB cord-010119-t1x9gknd 10098 7 supportive supportive JJ cord-010119-t1x9gknd 10098 8 therapy therapy NN cord-010119-t1x9gknd 10098 9 available available JJ cord-010119-t1x9gknd 10098 10 , , , cord-010119-t1x9gknd 10098 11 the the DT cord-010119-t1x9gknd 10098 12 best good JJS cord-010119-t1x9gknd 10098 13 mitigation mitigation NN cord-010119-t1x9gknd 10098 14 strategy strategy NN cord-010119-t1x9gknd 10098 15 is be VBZ cord-010119-t1x9gknd 10098 16 through through IN cord-010119-t1x9gknd 10098 17 vaccination vaccination NN cord-010119-t1x9gknd 10098 18 with with IN cord-010119-t1x9gknd 10098 19 live live JJ cord-010119-t1x9gknd 10098 20 attenuated attenuated JJ cord-010119-t1x9gknd 10098 21 vaccine vaccine NN cord-010119-t1x9gknd 10098 22 strains strain NNS cord-010119-t1x9gknd 10098 23 , , , cord-010119-t1x9gknd 10098 24 like like IN cord-010119-t1x9gknd 10098 25 the the DT cord-010119-t1x9gknd 10098 26 17D 17D NNP cord-010119-t1x9gknd 10098 27 - - HYPH cord-010119-t1x9gknd 10098 28 YFV yfv NN cord-010119-t1x9gknd 10098 29 strain strain NN cord-010119-t1x9gknd 10098 30 . . . cord-010119-t1x9gknd 10099 1 YFV YFV NNP cord-010119-t1x9gknd 10099 2 vaccine vaccine NN cord-010119-t1x9gknd 10099 3 is be VBZ cord-010119-t1x9gknd 10099 4 considered consider VBN cord-010119-t1x9gknd 10099 5 an an DT cord-010119-t1x9gknd 10099 6 effective effective JJ cord-010119-t1x9gknd 10099 7 and and CC cord-010119-t1x9gknd 10099 8 safe safe JJ cord-010119-t1x9gknd 10099 9 vaccine vaccine NN cord-010119-t1x9gknd 10099 10 ; ; : cord-010119-t1x9gknd 10099 11 however however RB cord-010119-t1x9gknd 10099 12 major major JJ cord-010119-t1x9gknd 10099 13 adverse adverse JJ cord-010119-t1x9gknd 10099 14 events event NNS cord-010119-t1x9gknd 10099 15 have have VBP cord-010119-t1x9gknd 10099 16 been be VBN cord-010119-t1x9gknd 10099 17 reported report VBN cord-010119-t1x9gknd 10099 18 including include VBG cord-010119-t1x9gknd 10099 19 neurologic neurologic JJ cord-010119-t1x9gknd 10099 20 and and CC cord-010119-t1x9gknd 10099 21 visceral visceral JJ cord-010119-t1x9gknd 10099 22 adverse adverse JJ cord-010119-t1x9gknd 10099 23 effects effect NNS cord-010119-t1x9gknd 10099 24 . . . cord-010119-t1x9gknd 10100 1 In in IN cord-010119-t1x9gknd 10100 2 addition addition NN cord-010119-t1x9gknd 10100 3 , , , cord-010119-t1x9gknd 10100 4 transfusion transfusion NN cord-010119-t1x9gknd 10100 5 transmission transmission NN cord-010119-t1x9gknd 10100 6 ( ( -LRB- cord-010119-t1x9gknd 10100 7 TT TT NNP cord-010119-t1x9gknd 10100 8 ) ) -RRB- cord-010119-t1x9gknd 10100 9 of of IN cord-010119-t1x9gknd 10100 10 live live JJ cord-010119-t1x9gknd 10100 11 attenuated attenuated JJ cord-010119-t1x9gknd 10100 12 YFV YFV NNP cord-010119-t1x9gknd 10100 13 has have VBZ cord-010119-t1x9gknd 10100 14 been be VBN cord-010119-t1x9gknd 10100 15 reported report VBN cord-010119-t1x9gknd 10100 16 with with IN cord-010119-t1x9gknd 10100 17 severe severe JJ cord-010119-t1x9gknd 10100 18 clinical clinical JJ cord-010119-t1x9gknd 10100 19 outcomes outcome NNS cord-010119-t1x9gknd 10100 20 , , , cord-010119-t1x9gknd 10100 21 especially especially RB cord-010119-t1x9gknd 10100 22 in in IN cord-010119-t1x9gknd 10100 23 immunosuppressed immunosuppressed JJ cord-010119-t1x9gknd 10100 24 patients patient NNS cord-010119-t1x9gknd 10100 25 . . . cord-010119-t1x9gknd 10101 1 In in IN cord-010119-t1x9gknd 10101 2 order order NN cord-010119-t1x9gknd 10101 3 to to TO cord-010119-t1x9gknd 10101 4 prevent prevent VB cord-010119-t1x9gknd 10101 5 TT TT NNP cord-010119-t1x9gknd 10101 6 by by IN cord-010119-t1x9gknd 10101 7 YFV YFV NNP cord-010119-t1x9gknd 10101 8 vaccine vaccine NN cord-010119-t1x9gknd 10101 9 strain strain NN cord-010119-t1x9gknd 10101 10 , , , cord-010119-t1x9gknd 10101 11 the the DT cord-010119-t1x9gknd 10101 12 AABB AABB NNP cord-010119-t1x9gknd 10101 13 recommends recommend VBZ cord-010119-t1x9gknd 10101 14 a a DT cord-010119-t1x9gknd 10101 15 2 2 CD cord-010119-t1x9gknd 10101 16 weekperiod weekperiod NN cord-010119-t1x9gknd 10101 17 deferral deferral NN cord-010119-t1x9gknd 10101 18 after after IN cord-010119-t1x9gknd 10101 19 YFV YFV NNP cord-010119-t1x9gknd 10101 20 vaccination vaccination NN cord-010119-t1x9gknd 10101 21 . . . cord-010119-t1x9gknd 10102 1 YFV YFV NNP cord-010119-t1x9gknd 10102 2 outbreaks outbreak NNS cord-010119-t1x9gknd 10102 3 and and CC cord-010119-t1x9gknd 10102 4 vaccination vaccination NN cord-010119-t1x9gknd 10102 5 campaigns campaign NNS cord-010119-t1x9gknd 10102 6 may may MD cord-010119-t1x9gknd 10102 7 therefore therefore RB cord-010119-t1x9gknd 10102 8 reduce reduce VB cord-010119-t1x9gknd 10102 9 blood blood NN cord-010119-t1x9gknd 10102 10 availability availability NN cord-010119-t1x9gknd 10102 11 . . . cord-010119-t1x9gknd 10103 1 This this DT cord-010119-t1x9gknd 10103 2 pilot pilot NN cord-010119-t1x9gknd 10103 3 study study NN cord-010119-t1x9gknd 10103 4 evaluated evaluate VBD cord-010119-t1x9gknd 10103 5 the the DT cord-010119-t1x9gknd 10103 6 ability ability NN cord-010119-t1x9gknd 10103 7 to to TO cord-010119-t1x9gknd 10103 8 inactivate inactivate VB cord-010119-t1x9gknd 10103 9 17D 17d CD cord-010119-t1x9gknd 10103 10 - - HYPH cord-010119-t1x9gknd 10103 11 YFV YFV NNP cord-010119-t1x9gknd 10103 12 using use VBG cord-010119-t1x9gknd 10103 13 amotosalen amotosalen VBN cord-010119-t1x9gknd 10103 14 ( ( -LRB- cord-010119-t1x9gknd 10103 15 S-59 S-59 NNP cord-010119-t1x9gknd 10103 16 ) ) -RRB- cord-010119-t1x9gknd 10103 17 and and CC cord-010119-t1x9gknd 10103 18 UVA UVA NNP cord-010119-t1x9gknd 10103 19 light light JJ cord-010119-t1x9gknd 10103 20 PRT PRT NNP cord-010119-t1x9gknd 10103 21 of of IN cord-010119-t1x9gknd 10103 22 platelet platelet NN cord-010119-t1x9gknd 10103 23 components component NNS cord-010119-t1x9gknd 10103 24 ( ( -LRB- cord-010119-t1x9gknd 10103 25 PC pc NN cord-010119-t1x9gknd 10103 26 ) ) -RRB- cord-010119-t1x9gknd 10103 27 . . . cord-010119-t1x9gknd 10104 1 Study Study NNP cord-010119-t1x9gknd 10104 2 Design Design NNP cord-010119-t1x9gknd 10104 3 / / SYM cord-010119-t1x9gknd 10104 4 Method method NN cord-010119-t1x9gknd 10104 5 : : : cord-010119-t1x9gknd 10104 6 PC pc NN cord-010119-t1x9gknd 10104 7 in in IN cord-010119-t1x9gknd 10104 8 65%PAS 65%pas CD cord-010119-t1x9gknd 10104 9 ( ( -LRB- cord-010119-t1x9gknd 10104 10 n53 n53 NN cord-010119-t1x9gknd 10104 11 ) ) -RRB- cord-010119-t1x9gknd 10104 12 or or CC cord-010119-t1x9gknd 10104 13 100 100 CD cord-010119-t1x9gknd 10104 14 % % NN cord-010119-t1x9gknd 10104 15 plasma plasma NN cord-010119-t1x9gknd 10104 16 ( ( -LRB- cord-010119-t1x9gknd 10104 17 n51 n51 NN cord-010119-t1x9gknd 10104 18 ) ) -RRB- cord-010119-t1x9gknd 10104 19 were be VBD cord-010119-t1x9gknd 10104 20 spiked spike VBN cord-010119-t1x9gknd 10104 21 with with IN cord-010119-t1x9gknd 10104 22 high high JJ cord-010119-t1x9gknd 10104 23 titers titer NNS cord-010119-t1x9gknd 10104 24 of of IN cord-010119-t1x9gknd 10104 25 17D 17D NNP cord-010119-t1x9gknd 10104 26 - - HYPH cord-010119-t1x9gknd 10104 27 YFV YFV NNP cord-010119-t1x9gknd 10104 28 and and CC cord-010119-t1x9gknd 10104 29 treated treat VBN cord-010119-t1x9gknd 10104 30 with with IN cord-010119-t1x9gknd 10104 31 S-59 S-59 NNP cord-010119-t1x9gknd 10104 32 / / SYM cord-010119-t1x9gknd 10104 33 UVA UVA NNP cord-010119-t1x9gknd 10104 34 PRT PRT NNP cord-010119-t1x9gknd 10104 35 . . . cord-010119-t1x9gknd 10105 1 Samples sample NNS cord-010119-t1x9gknd 10105 2 were be VBD cord-010119-t1x9gknd 10105 3 taken take VBN cord-010119-t1x9gknd 10105 4 pre pre JJ cord-010119-t1x9gknd 10105 5 - - JJ cord-010119-t1x9gknd 10105 6 and and CC cord-010119-t1x9gknd 10105 7 post post JJ cord-010119-t1x9gknd 10105 8 - - JJ cord-010119-t1x9gknd 10105 9 UVA uva JJ cord-010119-t1x9gknd 10105 10 illumination illumination NN cord-010119-t1x9gknd 10105 11 and and CC cord-010119-t1x9gknd 10105 12 infectious infectious JJ cord-010119-t1x9gknd 10105 13 titers titer NNS cord-010119-t1x9gknd 10105 14 were be VBD cord-010119-t1x9gknd 10105 15 determined determine VBN cord-010119-t1x9gknd 10105 16 , , , cord-010119-t1x9gknd 10105 17 by by IN cord-010119-t1x9gknd 10105 18 plaque plaque NN cord-010119-t1x9gknd 10105 19 assay assay NN cord-010119-t1x9gknd 10105 20 using use VBG cord-010119-t1x9gknd 10105 21 Vero76 Vero76 NNP cord-010119-t1x9gknd 10105 22 cells cell NNS cord-010119-t1x9gknd 10105 23 . . . cord-010119-t1x9gknd 10106 1 The the DT cord-010119-t1x9gknd 10106 2 extent extent NN cord-010119-t1x9gknd 10106 3 of of IN cord-010119-t1x9gknd 10106 4 inactivation inactivation NN cord-010119-t1x9gknd 10106 5 was be VBD cord-010119-t1x9gknd 10106 6 quantified quantify VBN cord-010119-t1x9gknd 10106 7 by by IN cord-010119-t1x9gknd 10106 8 comparing compare VBG cord-010119-t1x9gknd 10106 9 titers titer NNS cord-010119-t1x9gknd 10106 10 before before IN cord-010119-t1x9gknd 10106 11 and and CC cord-010119-t1x9gknd 10106 12 after after IN cord-010119-t1x9gknd 10106 13 inactivation inactivation NN cord-010119-t1x9gknd 10106 14 . . . cord-010119-t1x9gknd 10107 1 Results/ Results/ . cord-010119-t1x9gknd 10108 1 Finding finding NN cord-010119-t1x9gknd 10108 2 : : : cord-010119-t1x9gknd 10109 1 Pre pre JJ cord-010119-t1x9gknd 10109 2 - - JJ cord-010119-t1x9gknd 10109 3 PRT PRT NNP cord-010119-t1x9gknd 10109 4 infectious infectious JJ cord-010119-t1x9gknd 10109 5 titers titer NNS cord-010119-t1x9gknd 10109 6 were be VBD cord-010119-t1x9gknd 10109 7 4.71 4.71 CD cord-010119-t1x9gknd 10109 8 6 6 CD cord-010119-t1x9gknd 10109 9 0.7 0.7 CD cord-010119-t1x9gknd 10109 10 Log Log NNP cord-010119-t1x9gknd 10109 11 10 10 CD cord-010119-t1x9gknd 10109 12 PFU pfu NN cord-010119-t1x9gknd 10109 13 / / SYM cord-010119-t1x9gknd 10109 14 mL ml NN cord-010119-t1x9gknd 10109 15 for for IN cord-010119-t1x9gknd 10109 16 PC pc NN cord-010119-t1x9gknd 10109 17 in in IN cord-010119-t1x9gknd 10109 18 65 65 CD cord-010119-t1x9gknd 10109 19 % % NN cord-010119-t1x9gknd 10109 20 plasma plasma NN cord-010119-t1x9gknd 10109 21 and and CC cord-010119-t1x9gknd 10109 22 5.19 5.19 CD cord-010119-t1x9gknd 10109 23 Log Log NNP cord-010119-t1x9gknd 10110 1 10 10 CD cord-010119-t1x9gknd 10110 2 PFU pfu NN cord-010119-t1x9gknd 10110 3 / / SYM cord-010119-t1x9gknd 10110 4 mL ml NN cord-010119-t1x9gknd 10110 5 for for IN cord-010119-t1x9gknd 10110 6 PC pc NN cord-010119-t1x9gknd 10110 7 in in IN cord-010119-t1x9gknd 10110 8 100 100 CD cord-010119-t1x9gknd 10110 9 % % NN cord-010119-t1x9gknd 10110 10 plasma plasma NN cord-010119-t1x9gknd 10111 1 while while IN cord-010119-t1x9gknd 10111 2 titers titer NNS cord-010119-t1x9gknd 10111 3 in in IN cord-010119-t1x9gknd 10111 4 post post JJ cord-010119-t1x9gknd 10111 5 - - JJ cord-010119-t1x9gknd 10111 6 PRT PRT NNP cord-010119-t1x9gknd 10111 7 samples sample NNS cord-010119-t1x9gknd 10111 8 were be VBD cord-010119-t1x9gknd 10111 9 < < XX cord-010119-t1x9gknd 10111 10 -0.7 -0.7 NN cord-010119-t1x9gknd 10111 11 6 6 CD cord-010119-t1x9gknd 10111 12 0.0 0.0 CD cord-010119-t1x9gknd 10112 1 Log log VB cord-010119-t1x9gknd 10112 2 10 10 CD cord-010119-t1x9gknd 10112 3 PFU pfu NN cord-010119-t1x9gknd 10112 4 / / SYM cord-010119-t1x9gknd 10112 5 mL ml NN cord-010119-t1x9gknd 10112 6 for for IN cord-010119-t1x9gknd 10112 7 PC pc NN cord-010119-t1x9gknd 10112 8 in in IN cord-010119-t1x9gknd 10112 9 65 65 CD cord-010119-t1x9gknd 10112 10 % % NN cord-010119-t1x9gknd 10112 11 plasma plasma NN cord-010119-t1x9gknd 10112 12 and and CC cord-010119-t1x9gknd 10112 13 < < XX cord-010119-t1x9gknd 10112 14 -0.7 -0.7 NNP cord-010119-t1x9gknd 10112 15 Log Log NNP cord-010119-t1x9gknd 10112 16 10 10 CD cord-010119-t1x9gknd 10112 17 PFU pfu NN cord-010119-t1x9gknd 10112 18 / / SYM cord-010119-t1x9gknd 10112 19 mL ml NN cord-010119-t1x9gknd 10112 20 for for IN cord-010119-t1x9gknd 10112 21 PC pc NN cord-010119-t1x9gknd 10112 22 in in IN cord-010119-t1x9gknd 10112 23 100 100 CD cord-010119-t1x9gknd 10112 24 % % NN cord-010119-t1x9gknd 10112 25 plasma plasma NN cord-010119-t1x9gknd 10112 26 . . . cord-010119-t1x9gknd 10113 1 Inactivation inactivation NN cord-010119-t1x9gknd 10113 2 to to IN cord-010119-t1x9gknd 10113 3 the the DT cord-010119-t1x9gknd 10113 4 limit limit NN cord-010119-t1x9gknd 10113 5 of of IN cord-010119-t1x9gknd 10113 6 detection detection NN cord-010119-t1x9gknd 10113 7 of of IN cord-010119-t1x9gknd 10113 8 > > XX cord-010119-t1x9gknd 10113 9 5.41 5.41 CD cord-010119-t1x9gknd 10113 10 6 6 CD cord-010119-t1x9gknd 10113 11 0.7 0.7 CD cord-010119-t1x9gknd 10113 12 Log Log NNP cord-010119-t1x9gknd 10113 13 10 10 CD cord-010119-t1x9gknd 10113 14 or or CC cord-010119-t1x9gknd 10113 15 inactivation inactivation NN cord-010119-t1x9gknd 10113 16 of of IN cord-010119-t1x9gknd 10113 17 > > $ cord-010119-t1x9gknd 10113 18 4.71 4.71 CD cord-010119-t1x9gknd 10113 19 6 6 CD cord-010119-t1x9gknd 10113 20 0.7 0.7 CD cord-010119-t1x9gknd 10113 21 Log Log NNP cord-010119-t1x9gknd 10113 22 10 10 CD cord-010119-t1x9gknd 10114 1 PFU PFU NNP cord-010119-t1x9gknd 10114 2 / / SYM cord-010119-t1x9gknd 10114 3 mL ml NN cord-010119-t1x9gknd 10114 4 was be VBD cord-010119-t1x9gknd 10114 5 achieved achieve VBN cord-010119-t1x9gknd 10114 6 for for IN cord-010119-t1x9gknd 10114 7 PC pc NN cord-010119-t1x9gknd 10114 8 in in IN cord-010119-t1x9gknd 10114 9 65 65 CD cord-010119-t1x9gknd 10114 10 % % NN cord-010119-t1x9gknd 10114 11 plasma plasma NN cord-010119-t1x9gknd 10114 12 . . . cord-010119-t1x9gknd 10115 1 Inactivation inactivation NN cord-010119-t1x9gknd 10115 2 to to IN cord-010119-t1x9gknd 10115 3 the the DT cord-010119-t1x9gknd 10115 4 limit limit NN cord-010119-t1x9gknd 10115 5 of of IN cord-010119-t1x9gknd 10115 6 Background Background NNP cord-010119-t1x9gknd 10115 7 / / SYM cord-010119-t1x9gknd 10115 8 Case Case NNP cord-010119-t1x9gknd 10115 9 Studies Studies NNPS cord-010119-t1x9gknd 10115 10 : : : cord-010119-t1x9gknd 10116 1 The the DT cord-010119-t1x9gknd 10116 2 use use NN cord-010119-t1x9gknd 10116 3 of of IN cord-010119-t1x9gknd 10116 4 biotin biotin NN cord-010119-t1x9gknd 10116 5 as as IN cord-010119-t1x9gknd 10116 6 a a DT cord-010119-t1x9gknd 10116 7 supplement supplement NN cord-010119-t1x9gknd 10116 8 has have VBZ cord-010119-t1x9gknd 10116 9 increased increase VBN cord-010119-t1x9gknd 10116 10 in in IN cord-010119-t1x9gknd 10116 11 recent recent JJ cord-010119-t1x9gknd 10116 12 years year NNS cord-010119-t1x9gknd 10116 13 and and CC cord-010119-t1x9gknd 10116 14 many many JJ cord-010119-t1x9gknd 10116 15 health health NN cord-010119-t1x9gknd 10116 16 care care NN cord-010119-t1x9gknd 10116 17 professionals professional NNS cord-010119-t1x9gknd 10116 18 may may MD cord-010119-t1x9gknd 10116 19 not not RB cord-010119-t1x9gknd 10116 20 be be VB cord-010119-t1x9gknd 10116 21 aware aware JJ cord-010119-t1x9gknd 10116 22 of of IN cord-010119-t1x9gknd 10116 23 the the DT cord-010119-t1x9gknd 10116 24 high high JJ cord-010119-t1x9gknd 10116 25 dosage dosage NN cord-010119-t1x9gknd 10116 26 intake intake NN cord-010119-t1x9gknd 10116 27 by by IN cord-010119-t1x9gknd 10116 28 their -PRON- PRP$ cord-010119-t1x9gknd 10116 29 patients patient NNS cord-010119-t1x9gknd 10116 30 . . . cord-010119-t1x9gknd 10117 1 This this DT cord-010119-t1x9gknd 10117 2 high high JJ cord-010119-t1x9gknd 10117 3 dosage dosage NN cord-010119-t1x9gknd 10117 4 has have VBZ cord-010119-t1x9gknd 10117 5 resulted result VBN cord-010119-t1x9gknd 10117 6 in in IN cord-010119-t1x9gknd 10117 7 an an DT cord-010119-t1x9gknd 10117 8 increased increase VBN cord-010119-t1x9gknd 10117 9 prevalence prevalence NN cord-010119-t1x9gknd 10117 10 of of IN cord-010119-t1x9gknd 10117 11 individuals individual NNS cord-010119-t1x9gknd 10117 12 being be VBG cord-010119-t1x9gknd 10117 13 exposed expose VBN cord-010119-t1x9gknd 10117 14 to to IN cord-010119-t1x9gknd 10117 15 biotin biotin NN cord-010119-t1x9gknd 10117 16 levels level NNS cord-010119-t1x9gknd 10117 17 much much RB cord-010119-t1x9gknd 10117 18 greater great JJR cord-010119-t1x9gknd 10117 19 than than IN cord-010119-t1x9gknd 10117 20 the the DT cord-010119-t1x9gknd 10117 21 recommended recommend VBN cord-010119-t1x9gknd 10117 22 daily daily JJ cord-010119-t1x9gknd 10117 23 dose dose NN cord-010119-t1x9gknd 10117 24 and and CC cord-010119-t1x9gknd 10117 25 as as IN cord-010119-t1x9gknd 10117 26 a a DT cord-010119-t1x9gknd 10117 27 consequence consequence NN cord-010119-t1x9gknd 10117 28 , , , cord-010119-t1x9gknd 10117 29 has have VBZ cord-010119-t1x9gknd 10117 30 led lead VBN cord-010119-t1x9gknd 10117 31 to to IN cord-010119-t1x9gknd 10117 32 inaccurate inaccurate JJ cord-010119-t1x9gknd 10117 33 lab lab NN cord-010119-t1x9gknd 10117 34 results result NNS cord-010119-t1x9gknd 10117 35 for for IN cord-010119-t1x9gknd 10117 36 assays assay NNS cord-010119-t1x9gknd 10117 37 that that WDT cord-010119-t1x9gknd 10117 38 utilize utilize VBP cord-010119-t1x9gknd 10117 39 the the DT cord-010119-t1x9gknd 10117 40 free free JJ cord-010119-t1x9gknd 10117 41 capture capture NN cord-010119-t1x9gknd 10117 42 biotin biotin NN cord-010119-t1x9gknd 10117 43 - - HYPH cord-010119-t1x9gknd 10117 44 streptavidin streptavidin NNS cord-010119-t1x9gknd 10117 45 methodology methodology NN cord-010119-t1x9gknd 10117 46 . . . cord-010119-t1x9gknd 10118 1 Although although IN cord-010119-t1x9gknd 10118 2 Abbott Abbott NNP cord-010119-t1x9gknd 10118 3 's 's POS cord-010119-t1x9gknd 10118 4 Alinity Alinity NNP cord-010119-t1x9gknd 10118 5 s s POS cord-010119-t1x9gknd 10118 6 assays assay NNS cord-010119-t1x9gknd 10118 7 do do VBP cord-010119-t1x9gknd 10118 8 not not RB cord-010119-t1x9gknd 10118 9 utilize utilize VB cord-010119-t1x9gknd 10118 10 this this DT cord-010119-t1x9gknd 10118 11 free free JJ cord-010119-t1x9gknd 10118 12 capture capture NN cord-010119-t1x9gknd 10118 13 biotin biotin NN cord-010119-t1x9gknd 10118 14 - - HYPH cord-010119-t1x9gknd 10118 15 streptavidin streptavidin NN cord-010119-t1x9gknd 10118 16 methodology methodology NN cord-010119-t1x9gknd 10118 17 , , , cord-010119-t1x9gknd 10118 18 eight eight CD cord-010119-t1x9gknd 10118 19 assays assay NNS cord-010119-t1x9gknd 10118 20 developed develop VBN cord-010119-t1x9gknd 10118 21 for for IN cord-010119-t1x9gknd 10118 22 blood blood NN cord-010119-t1x9gknd 10118 23 screening screening NN cord-010119-t1x9gknd 10118 24 on on IN cord-010119-t1x9gknd 10118 25 the the DT cord-010119-t1x9gknd 10118 26 Alinity Alinity NNP cord-010119-t1x9gknd 10118 27 s s POS cord-010119-t1x9gknd 10118 28 system system NN cord-010119-t1x9gknd 10118 29 were be VBD cord-010119-t1x9gknd 10118 30 evaluated evaluate VBN cord-010119-t1x9gknd 10118 31 for for IN cord-010119-t1x9gknd 10118 32 biotin biotin NN cord-010119-t1x9gknd 10118 33 interference interference NN cord-010119-t1x9gknd 10118 34 to to TO cord-010119-t1x9gknd 10118 35 ensure ensure VB cord-010119-t1x9gknd 10118 36 there there EX cord-010119-t1x9gknd 10118 37 are be VBP cord-010119-t1x9gknd 10118 38 no no DT cord-010119-t1x9gknd 10118 39 unknown unknown JJ cord-010119-t1x9gknd 10118 40 consequences consequence NNS cord-010119-t1x9gknd 10118 41 of of IN cord-010119-t1x9gknd 10118 42 high high JJ cord-010119-t1x9gknd 10118 43 biotin biotin NN cord-010119-t1x9gknd 10118 44 levels level NNS cord-010119-t1x9gknd 10118 45 . . . cord-010119-t1x9gknd 10119 1 Study Study NNP cord-010119-t1x9gknd 10119 2 Design Design NNP cord-010119-t1x9gknd 10119 3 / / SYM cord-010119-t1x9gknd 10119 4 Methods method NNS cord-010119-t1x9gknd 10119 5 : : : cord-010119-t1x9gknd 10119 6 The the DT cord-010119-t1x9gknd 10119 7 purpose purpose NN cord-010119-t1x9gknd 10119 8 of of IN cord-010119-t1x9gknd 10119 9 this this DT cord-010119-t1x9gknd 10119 10 study study NN cord-010119-t1x9gknd 10119 11 was be VBD cord-010119-t1x9gknd 10119 12 to to TO cord-010119-t1x9gknd 10119 13 determine determine VB cord-010119-t1x9gknd 10119 14 if if IN cord-010119-t1x9gknd 10119 15 the the DT cord-010119-t1x9gknd 10119 16 eight eight CD cord-010119-t1x9gknd 10119 17 developed develop VBD cord-010119-t1x9gknd 10119 18 Abbott Abbott NNP cord-010119-t1x9gknd 10119 19 Alinity Alinity NNP cord-010119-t1x9gknd 10119 20 s s POS cord-010119-t1x9gknd 10119 21 assays assay NNS cord-010119-t1x9gknd 10119 22 would would MD cord-010119-t1x9gknd 10119 23 be be VB cord-010119-t1x9gknd 10119 24 susceptible susceptible JJ cord-010119-t1x9gknd 10119 25 to to IN cord-010119-t1x9gknd 10119 26 biotin biotin NN cord-010119-t1x9gknd 10119 27 interference interference NN cord-010119-t1x9gknd 10119 28 by by IN cord-010119-t1x9gknd 10119 29 evaluating evaluate VBG cord-010119-t1x9gknd 10119 30 their -PRON- PRP$ cord-010119-t1x9gknd 10119 31 performance performance NN cord-010119-t1x9gknd 10119 32 in in IN cord-010119-t1x9gknd 10119 33 the the DT cord-010119-t1x9gknd 10119 34 presence presence NN cord-010119-t1x9gknd 10119 35 of of IN cord-010119-t1x9gknd 10119 36 a a DT cord-010119-t1x9gknd 10119 37 high high JJ cord-010119-t1x9gknd 10119 38 concentration concentration NN cord-010119-t1x9gknd 10119 39 of of IN cord-010119-t1x9gknd 10119 40 biotin biotin NN cord-010119-t1x9gknd 10119 41 . . . cord-010119-t1x9gknd 10120 1 For for IN cord-010119-t1x9gknd 10120 2 each each DT cord-010119-t1x9gknd 10120 3 of of IN cord-010119-t1x9gknd 10120 4 the the DT cord-010119-t1x9gknd 10120 5 Alinity Alinity NNP cord-010119-t1x9gknd 10120 6 s s POS cord-010119-t1x9gknd 10120 7 assays assay NNS cord-010119-t1x9gknd 10120 8 evaluated evaluate VBD cord-010119-t1x9gknd 10120 9 ( ( -LRB- cord-010119-t1x9gknd 10120 10 HIV HIV NNP cord-010119-t1x9gknd 10120 11 Ag Ag NNP cord-010119-t1x9gknd 10120 12 / / SYM cord-010119-t1x9gknd 10120 13 Ab Ab NNP cord-010119-t1x9gknd 10120 14 Combo Combo NNP cord-010119-t1x9gknd 10120 15 , , , cord-010119-t1x9gknd 10121 1 HTLV HTLV NNP cord-010119-t1x9gknd 10122 1 I I NNP cord-010119-t1x9gknd 10122 2 / / SYM cord-010119-t1x9gknd 10122 3 II II NNP cord-010119-t1x9gknd 10122 4 , , , cord-010119-t1x9gknd 10122 5 Anti Anti NNP cord-010119-t1x9gknd 10122 6 - - NNP cord-010119-t1x9gknd 10122 7 HCV HCV NNP cord-010119-t1x9gknd 10122 8 , , , cord-010119-t1x9gknd 10122 9 Chagas Chagas NNP cord-010119-t1x9gknd 10122 10 , , , cord-010119-t1x9gknd 10122 11 HBsAg hbsag ADD cord-010119-t1x9gknd 10122 12 , , , cord-010119-t1x9gknd 10122 13 Anti Anti NNP cord-010119-t1x9gknd 10122 14 - - JJ cord-010119-t1x9gknd 10122 15 HBc HBc NNP cord-010119-t1x9gknd 10122 16 , , , cord-010119-t1x9gknd 10122 17 Syphilis Syphilis NNP cord-010119-t1x9gknd 10122 18 , , , cord-010119-t1x9gknd 10122 19 and and CC cord-010119-t1x9gknd 10122 20 CMV CMV NNP cord-010119-t1x9gknd 10122 21 IgG igg NN cord-010119-t1x9gknd 10122 22 ) ) -RRB- cord-010119-t1x9gknd 10123 1 , , , cord-010119-t1x9gknd 10123 2 samples sample NNS cord-010119-t1x9gknd 10123 3 spiked spike VBN cord-010119-t1x9gknd 10123 4 with with IN cord-010119-t1x9gknd 10123 5 a a DT cord-010119-t1x9gknd 10123 6 concentration concentration NN cord-010119-t1x9gknd 10123 7 of of IN cord-010119-t1x9gknd 10123 8 biotin biotin NN cord-010119-t1x9gknd 10123 9 at at IN cord-010119-t1x9gknd 10124 1 approximately approximately RB cord-010119-t1x9gknd 10124 2 1000 1000 CD cord-010119-t1x9gknd 10124 3 ng ng NN cord-010119-t1x9gknd 10124 4 / / SYM cord-010119-t1x9gknd 10124 5 mL ml NN cord-010119-t1x9gknd 10124 6 were be VBD cord-010119-t1x9gknd 10124 7 tested test VBN cord-010119-t1x9gknd 10124 8 against against IN cord-010119-t1x9gknd 10124 9 a a DT cord-010119-t1x9gknd 10124 10 control control NN cord-010119-t1x9gknd 10124 11 ( ( -LRB- cord-010119-t1x9gknd 10124 12 unspiked unspiked JJ cord-010119-t1x9gknd 10124 13 ) ) -RRB- cord-010119-t1x9gknd 10124 14 sample sample NN cord-010119-t1x9gknd 10124 15 preparation preparation NN cord-010119-t1x9gknd 10124 16 to to TO cord-010119-t1x9gknd 10124 17 determine determine VB cord-010119-t1x9gknd 10124 18 if if IN cord-010119-t1x9gknd 10124 19 there there EX cord-010119-t1x9gknd 10124 20 was be VBD cord-010119-t1x9gknd 10124 21 a a DT cord-010119-t1x9gknd 10124 22 difference difference NN cord-010119-t1x9gknd 10124 23 between between IN cord-010119-t1x9gknd 10124 24 the the DT cord-010119-t1x9gknd 10124 25 control control NN cord-010119-t1x9gknd 10124 26 and and CC cord-010119-t1x9gknd 10124 27 biotin biotin NN cord-010119-t1x9gknd 10124 28 containing contain VBG cord-010119-t1x9gknd 10124 29 samples sample NNS cord-010119-t1x9gknd 10124 30 . . . cord-010119-t1x9gknd 10125 1 Two two CD cord-010119-t1x9gknd 10125 2 samples sample NNS cord-010119-t1x9gknd 10125 3 , , , cord-010119-t1x9gknd 10125 4 one one CD cord-010119-t1x9gknd 10125 5 negative negative JJ cord-010119-t1x9gknd 10125 6 and and CC cord-010119-t1x9gknd 10125 7 one one CD cord-010119-t1x9gknd 10125 8 positive positive JJ cord-010119-t1x9gknd 10125 9 , , , cord-010119-t1x9gknd 10125 10 were be VBD cord-010119-t1x9gknd 10125 11 tested test VBN cord-010119-t1x9gknd 10125 12 with with IN cord-010119-t1x9gknd 10125 13 all all DT cord-010119-t1x9gknd 10125 14 assays assay NNS cord-010119-t1x9gknd 10125 15 , , , cord-010119-t1x9gknd 10125 16 except except IN cord-010119-t1x9gknd 10125 17 the the DT cord-010119-t1x9gknd 10125 18 HIV HIV NNP cord-010119-t1x9gknd 10125 19 and and CC cord-010119-t1x9gknd 10125 20 HTLV HTLV NNP cord-010119-t1x9gknd 10125 21 assays assay NNS cord-010119-t1x9gknd 10125 22 , , , cord-010119-t1x9gknd 10125 23 which which WDT cord-010119-t1x9gknd 10125 24 each each DT cord-010119-t1x9gknd 10125 25 tested test VBD cord-010119-t1x9gknd 10125 26 two two CD cord-010119-t1x9gknd 10125 27 positive positive JJ cord-010119-t1x9gknd 10125 28 samples sample NNS cord-010119-t1x9gknd 10125 29 ( ( -LRB- cord-010119-t1x9gknd 10125 30 1 1 CD cord-010119-t1x9gknd 10125 31 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 10125 32 antibody antibody NN cord-010119-t1x9gknd 10125 33 and and CC cord-010119-t1x9gknd 10125 34 1 1 CD cord-010119-t1x9gknd 10125 35 HIV-1 HIV-1 NNP cord-010119-t1x9gknd 10125 36 p24 p24 NN cord-010119-t1x9gknd 10125 37 antigen antigen NN cord-010119-t1x9gknd 10125 38 , , , cord-010119-t1x9gknd 10125 39 and and CC cord-010119-t1x9gknd 10125 40 1 1 CD cord-010119-t1x9gknd 10125 41 HTLV HTLV NNP cord-010119-t1x9gknd 10125 42 - - HYPH cord-010119-t1x9gknd 10125 43 I i NN cord-010119-t1x9gknd 10125 44 antibody antibody NN cord-010119-t1x9gknd 10125 45 and and CC cord-010119-t1x9gknd 10125 46 1 1 CD cord-010119-t1x9gknd 10125 47 HTLV HTLV NNP cord-010119-t1x9gknd 10125 48 - - HYPH cord-010119-t1x9gknd 10125 49 II II NNP cord-010119-t1x9gknd 10125 50 antibody antibody NN cord-010119-t1x9gknd 10125 51 , , , cord-010119-t1x9gknd 10125 52 respectively respectively RB cord-010119-t1x9gknd 10125 53 ) ) -RRB- cord-010119-t1x9gknd 10125 54 . . . cord-010119-t1x9gknd 10126 1 Results result NNS cord-010119-t1x9gknd 10126 2 / / SYM cord-010119-t1x9gknd 10126 3 Findings finding NNS cord-010119-t1x9gknd 10126 4 : : : cord-010119-t1x9gknd 10127 1 For for IN cord-010119-t1x9gknd 10127 2 the the DT cord-010119-t1x9gknd 10127 3 negative negative JJ cord-010119-t1x9gknd 10127 4 samples sample NNS cord-010119-t1x9gknd 10127 5 , , , cord-010119-t1x9gknd 10127 6 the the DT cord-010119-t1x9gknd 10127 7 sample sample NN cord-010119-t1x9gknd 10127 8 to to IN cord-010119-t1x9gknd 10127 9 cutoff cutoff NN cord-010119-t1x9gknd 10127 10 ( ( -LRB- cord-010119-t1x9gknd 10127 11 S S NNP cord-010119-t1x9gknd 10127 12 / / SYM cord-010119-t1x9gknd 10127 13 CO CO NNP cord-010119-t1x9gknd 10127 14 ) ) -RRB- cord-010119-t1x9gknd 10127 15 differences difference NNS cord-010119-t1x9gknd 10127 16 between between IN cord-010119-t1x9gknd 10127 17 the the DT cord-010119-t1x9gknd 10127 18 biotin biotin NN cord-010119-t1x9gknd 10127 19 spiked spike VBN cord-010119-t1x9gknd 10127 20 and and CC cord-010119-t1x9gknd 10127 21 control control NN cord-010119-t1x9gknd 10127 22 were be VBD cord-010119-t1x9gknd 10127 23 0.00 0.00 CD cord-010119-t1x9gknd 10127 24 for for IN cord-010119-t1x9gknd 10127 25 HCV HCV NNP cord-010119-t1x9gknd 10127 26 , , , cord-010119-t1x9gknd 10127 27 HBc HBc NNP cord-010119-t1x9gknd 10127 28 , , , cord-010119-t1x9gknd 10127 29 Syphilis Syphilis NNP cord-010119-t1x9gknd 10127 30 , , , cord-010119-t1x9gknd 10127 31 CMV CMV NNP cord-010119-t1x9gknd 10127 32 IgG igg NN cord-010119-t1x9gknd 10127 33 , , , cord-010119-t1x9gknd 10127 34 and and CC cord-010119-t1x9gknd 10127 35 Chagas Chagas NNP cord-010119-t1x9gknd 10127 36 , , , cord-010119-t1x9gknd 10127 37 0.01 0.01 CD cord-010119-t1x9gknd 10127 38 for for IN cord-010119-t1x9gknd 10127 39 HIV HIV NNP cord-010119-t1x9gknd 10127 40 Ag Ag NNP cord-010119-t1x9gknd 10127 41 / / SYM cord-010119-t1x9gknd 10127 42 Ab Ab NNP cord-010119-t1x9gknd 10127 43 and and CC cord-010119-t1x9gknd 10127 44 HTLV HTLV NNP cord-010119-t1x9gknd 10127 45 I I NNP cord-010119-t1x9gknd 10127 46 / / SYM cord-010119-t1x9gknd 10127 47 II II NNP cord-010119-t1x9gknd 10127 48 , , , cord-010119-t1x9gknd 10127 49 and and CC cord-010119-t1x9gknd 10127 50 0.03 0.03 CD cord-010119-t1x9gknd 10127 51 for for IN cord-010119-t1x9gknd 10127 52 HBsAg hbsag ADD cord-010119-t1x9gknd 10127 53 . . . cord-010119-t1x9gknd 10128 1 For for IN cord-010119-t1x9gknd 10128 2 the the DT cord-010119-t1x9gknd 10128 3 positive positive JJ cord-010119-t1x9gknd 10128 4 samples sample NNS cord-010119-t1x9gknd 10128 5 , , , cord-010119-t1x9gknd 10128 6 the the DT cord-010119-t1x9gknd 10128 7 mean mean NNP cord-010119-t1x9gknd 10128 8 S S NNP cord-010119-t1x9gknd 10128 9 / / SYM cord-010119-t1x9gknd 10128 10 CO co NN cord-010119-t1x9gknd 10128 11 % % NN cord-010119-t1x9gknd 10128 12 differences difference NNS cord-010119-t1x9gknd 10128 13 between between IN cord-010119-t1x9gknd 10128 14 the the DT cord-010119-t1x9gknd 10128 15 biotin biotin NN cord-010119-t1x9gknd 10128 16 spiked spike VBN cord-010119-t1x9gknd 10128 17 and and CC cord-010119-t1x9gknd 10128 18 control control NN cord-010119-t1x9gknd 10128 19 were be VBD cord-010119-t1x9gknd 10128 20 0.00 0.00 CD cord-010119-t1x9gknd 10128 21 % % NN cord-010119-t1x9gknd 10128 22 ( ( -LRB- cord-010119-t1x9gknd 10128 23 antibody antibody NN cord-010119-t1x9gknd 10128 24 sample sample NN cord-010119-t1x9gknd 10128 25 ) ) -RRB- cord-010119-t1x9gknd 10128 26 and and CC cord-010119-t1x9gknd 10128 27 0.36 0.36 CD cord-010119-t1x9gknd 10128 28 % % NN cord-010119-t1x9gknd 10128 29 ( ( -LRB- cord-010119-t1x9gknd 10128 30 antigen antigen NN cord-010119-t1x9gknd 10128 31 sample sample NN cord-010119-t1x9gknd 10128 32 ) ) -RRB- cord-010119-t1x9gknd 10128 33 for for IN cord-010119-t1x9gknd 10128 34 HIV HIV NNP cord-010119-t1x9gknd 10128 35 Ag Ag NNP cord-010119-t1x9gknd 10128 36 / / SYM cord-010119-t1x9gknd 10128 37 Ab Ab NNP cord-010119-t1x9gknd 10128 38 Combo Combo NNP cord-010119-t1x9gknd 10128 39 ; ; : cord-010119-t1x9gknd 10128 40 0.90 0.90 CD cord-010119-t1x9gknd 10128 41 % % NN cord-010119-t1x9gknd 10128 42 ( ( -LRB- cord-010119-t1x9gknd 10128 43 HTLV HTLV NNP cord-010119-t1x9gknd 10128 44 I -PRON- PRP cord-010119-t1x9gknd 10128 45 antibody antibody NN cord-010119-t1x9gknd 10128 46 sample sample NN cord-010119-t1x9gknd 10128 47 ) ) -RRB- cord-010119-t1x9gknd 10128 48 and and CC cord-010119-t1x9gknd 10128 49 0.32 0.32 CD cord-010119-t1x9gknd 10128 50 % % NN cord-010119-t1x9gknd 10128 51 ( ( -LRB- cord-010119-t1x9gknd 10128 52 HTLV HTLV NNP cord-010119-t1x9gknd 10128 53 II II NNP cord-010119-t1x9gknd 10128 54 antibody antibody NN cord-010119-t1x9gknd 10128 55 sample sample NN cord-010119-t1x9gknd 10128 56 ) ) -RRB- cord-010119-t1x9gknd 10128 57 ; ; : cord-010119-t1x9gknd 10128 58 -1.43 -1.43 CD cord-010119-t1x9gknd 10128 59 % % NN cord-010119-t1x9gknd 10128 60 for for IN cord-010119-t1x9gknd 10128 61 Anti Anti NNP cord-010119-t1x9gknd 10128 62 - - NNP cord-010119-t1x9gknd 10128 63 HCV HCV NNP cord-010119-t1x9gknd 10128 64 , , , cord-010119-t1x9gknd 10128 65 -2.52 -2.52 CD cord-010119-t1x9gknd 10128 66 % % NN cord-010119-t1x9gknd 10128 67 for for IN cord-010119-t1x9gknd 10128 68 Chagas Chagas NNP cord-010119-t1x9gknd 10128 69 , , , cord-010119-t1x9gknd 10128 70 -0.71 -0.71 CD cord-010119-t1x9gknd 10128 71 % % NN cord-010119-t1x9gknd 10128 72 for for IN cord-010119-t1x9gknd 10128 73 HBsAg HBsAg NNP cord-010119-t1x9gknd 10128 74 , , , cord-010119-t1x9gknd 10128 75 -0.37 -0.37 CD cord-010119-t1x9gknd 10128 76 % % NN cord-010119-t1x9gknd 10128 77 for for IN cord-010119-t1x9gknd 10128 78 Anti Anti NNP cord-010119-t1x9gknd 10128 79 - - JJ cord-010119-t1x9gknd 10128 80 HBc HBc NNS cord-010119-t1x9gknd 10128 81 , , , cord-010119-t1x9gknd 10128 82 -1.62 -1.62 CD cord-010119-t1x9gknd 10128 83 % % NN cord-010119-t1x9gknd 10128 84 for for IN cord-010119-t1x9gknd 10128 85 Syphilis Syphilis NNP cord-010119-t1x9gknd 10128 86 , , , cord-010119-t1x9gknd 10128 87 and and CC cord-010119-t1x9gknd 10128 88 -0.59 -0.59 CD cord-010119-t1x9gknd 10128 89 % % NN cord-010119-t1x9gknd 10128 90 for for IN cord-010119-t1x9gknd 10128 91 CMV CMV NNP cord-010119-t1x9gknd 10129 1 IgG. IgG. NNP cord-010119-t1x9gknd 10129 2 Conclusion conclusion NN cord-010119-t1x9gknd 10129 3 : : : cord-010119-t1x9gknd 10130 1 Eight eight CD cord-010119-t1x9gknd 10130 2 Abbott Abbott NNP cord-010119-t1x9gknd 10130 3 Alinity Alinity NNP cord-010119-t1x9gknd 10130 4 s s POS cord-010119-t1x9gknd 10130 5 assays assay NNS cord-010119-t1x9gknd 10130 6 were be VBD cord-010119-t1x9gknd 10130 7 evaluated evaluate VBN cord-010119-t1x9gknd 10130 8 to to TO cord-010119-t1x9gknd 10130 9 determine determine VB cord-010119-t1x9gknd 10130 10 if if IN cord-010119-t1x9gknd 10130 11 they -PRON- PRP cord-010119-t1x9gknd 10130 12 were be VBD cord-010119-t1x9gknd 10130 13 susceptible susceptible JJ cord-010119-t1x9gknd 10130 14 to to IN cord-010119-t1x9gknd 10130 15 biotin biotin NN cord-010119-t1x9gknd 10130 16 interference interference NN cord-010119-t1x9gknd 10130 17 . . . cord-010119-t1x9gknd 10131 1 These these DT cord-010119-t1x9gknd 10131 2 results result NNS cord-010119-t1x9gknd 10131 3 indicate indicate VBP cord-010119-t1x9gknd 10131 4 that that IN cord-010119-t1x9gknd 10131 5 the the DT cord-010119-t1x9gknd 10131 6 eight eight CD cord-010119-t1x9gknd 10131 7 Alinity Alinity NNP cord-010119-t1x9gknd 10131 8 s s POS cord-010119-t1x9gknd 10131 9 assays assay NNS cord-010119-t1x9gknd 10131 10 do do VBP cord-010119-t1x9gknd 10131 11 not not RB cord-010119-t1x9gknd 10131 12 show show VB cord-010119-t1x9gknd 10131 13 susceptibility susceptibility NN cord-010119-t1x9gknd 10131 14 to to IN cord-010119-t1x9gknd 10131 15 biotin biotin NN cord-010119-t1x9gknd 10131 16 interference interference NN cord-010119-t1x9gknd 10131 17 at at IN cord-010119-t1x9gknd 10131 18 an an DT cord-010119-t1x9gknd 10131 19 approximate approximate JJ cord-010119-t1x9gknd 10131 20 concentration concentration NN cord-010119-t1x9gknd 10131 21 of of IN cord-010119-t1x9gknd 10131 22 1000 1000 CD cord-010119-t1x9gknd 10131 23 ng ng NN cord-010119-t1x9gknd 10131 24 / / SYM cord-010119-t1x9gknd 10131 25 mL. mL. NNP cord-010119-t1x9gknd 10131 26 Robustness Robustness NNP cord-010119-t1x9gknd 10131 27 of of IN cord-010119-t1x9gknd 10131 28 the the DT cord-010119-t1x9gknd 10131 29 Abbott Abbott NNP cord-010119-t1x9gknd 10131 30 PRISM PRISM NNP cord-010119-t1x9gknd 10131 31 Methods Methods NNPS cord-010119-t1x9gknd 10131 32 to to IN cord-010119-t1x9gknd 10131 33 Biotin Biotin NNP cord-010119-t1x9gknd 10131 34 Interference Interference NNP cord-010119-t1x9gknd 10131 35 C C NNP cord-010119-t1x9gknd 10131 36 Fischer Fischer NNP cord-010119-t1x9gknd 10131 37 1 1 CD cord-010119-t1x9gknd 10131 38 , , , cord-010119-t1x9gknd 10131 39 R R NNP cord-010119-t1x9gknd 10131 40 Schneider Schneider NNP cord-010119-t1x9gknd 10131 41 2 2 CD cord-010119-t1x9gknd 10131 42 , , , cord-010119-t1x9gknd 10131 43 W W NNP cord-010119-t1x9gknd 10131 44 Leonard Leonard NNP cord-010119-t1x9gknd 10131 45 2 2 CD cord-010119-t1x9gknd 10131 46 , , , cord-010119-t1x9gknd 10131 47 M M NNP cord-010119-t1x9gknd 10131 48 Cobb Cobb NNP cord-010119-t1x9gknd 10131 49 3 3 CD cord-010119-t1x9gknd 10131 50 , , , cord-010119-t1x9gknd 10131 51 G G NNP cord-010119-t1x9gknd 10131 52 Schlauder Schlauder NNP cord-010119-t1x9gknd 10131 53 3 3 NNP cord-010119-t1x9gknd 10131 54 , , , cord-010119-t1x9gknd 10131 55 G G NNP cord-010119-t1x9gknd 10131 56 Williams Williams NNP cord-010119-t1x9gknd 10131 57 3 3 CD cord-010119-t1x9gknd 10131 58 , , , cord-010119-t1x9gknd 10131 59 M M NNP cord-010119-t1x9gknd 10131 60 Zuske Zuske NNP cord-010119-t1x9gknd 10131 61 2 2 CD cord-010119-t1x9gknd 10131 62 M M NNP cord-010119-t1x9gknd 10131 63 Janulis Janulis NNP cord-010119-t1x9gknd 10131 64 * * NFP cord-010119-t1x9gknd 10131 65 2 2 CD cord-010119-t1x9gknd 10131 66 . . . cord-010119-t1x9gknd 10131 67 1 1 CD cord-010119-t1x9gknd 10131 68 Transfusion Transfusion NNP cord-010119-t1x9gknd 10131 69 Medicine Medicine NNP cord-010119-t1x9gknd 10131 70 , , , cord-010119-t1x9gknd 10131 71 Abbott Abbott NNP cord-010119-t1x9gknd 10131 72 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 10131 73 , , , cord-010119-t1x9gknd 10131 74 Wiesbaden Wiesbaden NNP cord-010119-t1x9gknd 10131 75 , , , cord-010119-t1x9gknd 10131 76 Germany Germany NNP cord-010119-t1x9gknd 10131 77 , , , cord-010119-t1x9gknd 10131 78 2 2 CD cord-010119-t1x9gknd 10131 79 ADD add NN cord-010119-t1x9gknd 10131 80 Diagnostics diagnostic NNS cord-010119-t1x9gknd 10131 81 , , , cord-010119-t1x9gknd 10131 82 3 3 CD cord-010119-t1x9gknd 10131 83 Transfusion Transfusion NNP cord-010119-t1x9gknd 10131 84 Medicine Medicine NNP cord-010119-t1x9gknd 10131 85 , , , cord-010119-t1x9gknd 10131 86 Abbott Abbott NNP cord-010119-t1x9gknd 10131 87 Laboratories Laboratories NNP cord-010119-t1x9gknd 10131 88 , , , cord-010119-t1x9gknd 10131 89 Chicago Chicago NNP cord-010119-t1x9gknd 10131 90 , , , cord-010119-t1x9gknd 10131 91 United United NNP cord-010119-t1x9gknd 10131 92 States States NNP cord-010119-t1x9gknd 10131 93 Background Background NNP cord-010119-t1x9gknd 10131 94 / / SYM cord-010119-t1x9gknd 10131 95 Case Case NNP cord-010119-t1x9gknd 10131 96 Studies Studies NNPS cord-010119-t1x9gknd 10131 97 : : : cord-010119-t1x9gknd 10132 1 The the DT cord-010119-t1x9gknd 10132 2 use use NN cord-010119-t1x9gknd 10132 3 of of IN cord-010119-t1x9gknd 10132 4 biotin biotin NN cord-010119-t1x9gknd 10132 5 as as IN cord-010119-t1x9gknd 10132 6 a a DT cord-010119-t1x9gknd 10132 7 dietary dietary JJ cord-010119-t1x9gknd 10132 8 supplement supplement NN cord-010119-t1x9gknd 10132 9 has have VBZ cord-010119-t1x9gknd 10132 10 increased increase VBN cord-010119-t1x9gknd 10132 11 significantly significantly RB cord-010119-t1x9gknd 10132 12 in in IN cord-010119-t1x9gknd 10132 13 recent recent JJ cord-010119-t1x9gknd 10132 14 years year NNS cord-010119-t1x9gknd 10132 15 and and CC cord-010119-t1x9gknd 10132 16 many many JJ cord-010119-t1x9gknd 10132 17 health health NN cord-010119-t1x9gknd 10132 18 care care NN cord-010119-t1x9gknd 10132 19 professionals professional NNS cord-010119-t1x9gknd 10132 20 do do VBP cord-010119-t1x9gknd 10132 21 not not RB cord-010119-t1x9gknd 10132 22 realize realize VB cord-010119-t1x9gknd 10132 23 their -PRON- PRP$ cord-010119-t1x9gknd 10132 24 patients patient NNS cord-010119-t1x9gknd 10132 25 are be VBP cord-010119-t1x9gknd 10132 26 taking take VBG cord-010119-t1x9gknd 10132 27 high high JJ cord-010119-t1x9gknd 10132 28 doses dose NNS cord-010119-t1x9gknd 10132 29 . . . cord-010119-t1x9gknd 10133 1 The the DT cord-010119-t1x9gknd 10133 2 increase increase NN cord-010119-t1x9gknd 10133 3 has have VBZ cord-010119-t1x9gknd 10133 4 resulted result VBN cord-010119-t1x9gknd 10133 5 in in IN cord-010119-t1x9gknd 10133 6 an an DT cord-010119-t1x9gknd 10133 7 increased increase VBN cord-010119-t1x9gknd 10133 8 prevalence prevalence NN cord-010119-t1x9gknd 10133 9 of of IN cord-010119-t1x9gknd 10133 10 people people NNS cord-010119-t1x9gknd 10133 11 being be VBG cord-010119-t1x9gknd 10133 12 exposed expose VBN cord-010119-t1x9gknd 10133 13 to to IN cord-010119-t1x9gknd 10133 14 biotin biotin NN cord-010119-t1x9gknd 10133 15 levels level NNS cord-010119-t1x9gknd 10133 16 much much RB cord-010119-t1x9gknd 10133 17 higher high JJR cord-010119-t1x9gknd 10133 18 than than IN cord-010119-t1x9gknd 10133 19 the the DT cord-010119-t1x9gknd 10133 20 recommended recommend VBN cord-010119-t1x9gknd 10133 21 daily daily JJ cord-010119-t1x9gknd 10133 22 dose dose NN cord-010119-t1x9gknd 10133 23 and and CC cord-010119-t1x9gknd 10133 24 as as IN cord-010119-t1x9gknd 10133 25 a a DT cord-010119-t1x9gknd 10133 26 consequence consequence NN cord-010119-t1x9gknd 10133 27 , , , cord-010119-t1x9gknd 10133 28 potentially potentially RB cord-010119-t1x9gknd 10133 29 inaccurate inaccurate JJ cord-010119-t1x9gknd 10133 30 lab lab NN cord-010119-t1x9gknd 10133 31 results result NNS cord-010119-t1x9gknd 10133 32 for for IN cord-010119-t1x9gknd 10133 33 assays assay NNS cord-010119-t1x9gknd 10133 34 that that WDT cord-010119-t1x9gknd 10133 35 utilize utilize VBP cord-010119-t1x9gknd 10133 36 the the DT cord-010119-t1x9gknd 10133 37 free free JJ cord-010119-t1x9gknd 10133 38 capture capture NN cord-010119-t1x9gknd 10133 39 biotin biotin NN cord-010119-t1x9gknd 10133 40 - - HYPH cord-010119-t1x9gknd 10133 41 streptavidin streptavidin NNS cord-010119-t1x9gknd 10133 42 methodology methodology NN cord-010119-t1x9gknd 10133 43 . . . cord-010119-t1x9gknd 10134 1 The the DT cord-010119-t1x9gknd 10134 2 purpose purpose NN cord-010119-t1x9gknd 10134 3 of of IN cord-010119-t1x9gknd 10134 4 this this DT cord-010119-t1x9gknd 10134 5 study study NN cord-010119-t1x9gknd 10134 6 was be VBD cord-010119-t1x9gknd 10134 7 to to TO cord-010119-t1x9gknd 10134 8 identify identify VB cord-010119-t1x9gknd 10134 9 any any DT cord-010119-t1x9gknd 10134 10 Abbott Abbott NNP cord-010119-t1x9gknd 10134 11 PRISM PRISM NNP cord-010119-t1x9gknd 10134 12 assays assay NNS cord-010119-t1x9gknd 10134 13 that that WDT cord-010119-t1x9gknd 10134 14 may may MD cord-010119-t1x9gknd 10134 15 be be VB cord-010119-t1x9gknd 10134 16 susceptible susceptible JJ cord-010119-t1x9gknd 10134 17 to to IN cord-010119-t1x9gknd 10134 18 biotin biotin NN cord-010119-t1x9gknd 10134 19 interference interference NN cord-010119-t1x9gknd 10134 20 based base VBN cord-010119-t1x9gknd 10134 21 on on IN cord-010119-t1x9gknd 10134 22 assay assay NN cord-010119-t1x9gknd 10134 23 design design NN cord-010119-t1x9gknd 10134 24 and and CC cord-010119-t1x9gknd 10134 25 then then RB cord-010119-t1x9gknd 10134 26 evaluate evaluate VB cord-010119-t1x9gknd 10134 27 the the DT cord-010119-t1x9gknd 10134 28 performance performance NN cord-010119-t1x9gknd 10134 29 of of IN cord-010119-t1x9gknd 10134 30 those those DT cord-010119-t1x9gknd 10134 31 assays assay NNS cord-010119-t1x9gknd 10134 32 with with IN cord-010119-t1x9gknd 10134 33 high high JJ cord-010119-t1x9gknd 10134 34 concentrations concentration NNS cord-010119-t1x9gknd 10134 35 of of IN cord-010119-t1x9gknd 10134 36 biotin biotin NN cord-010119-t1x9gknd 10134 37 . . . cord-010119-t1x9gknd 10135 1 After after IN cord-010119-t1x9gknd 10135 2 a a DT cord-010119-t1x9gknd 10135 3 comprehensive comprehensive JJ cord-010119-t1x9gknd 10135 4 review review NN cord-010119-t1x9gknd 10135 5 of of IN cord-010119-t1x9gknd 10135 6 Abbott Abbott NNP cord-010119-t1x9gknd 10135 7 's 's POS cord-010119-t1x9gknd 10135 8 current current NN cord-010119-t1x9gknd 10135 9 on on IN cord-010119-t1x9gknd 10135 10 market market NN cord-010119-t1x9gknd 10135 11 PRISM prism NN cord-010119-t1x9gknd 10135 12 assays assay NNS cord-010119-t1x9gknd 10135 13 , , , cord-010119-t1x9gknd 10135 14 no no DT cord-010119-t1x9gknd 10135 15 assays assay NNS cord-010119-t1x9gknd 10135 16 were be VBD cord-010119-t1x9gknd 10135 17 identified identify VBN cord-010119-t1x9gknd 10135 18 that that WDT cord-010119-t1x9gknd 10135 19 utilize utilize VBP cord-010119-t1x9gknd 10135 20 biotin biotin NN cord-010119-t1x9gknd 10135 21 - - HYPH cord-010119-t1x9gknd 10135 22 streptavidin streptavidin NN cord-010119-t1x9gknd 10135 23 capture capture NN cord-010119-t1x9gknd 10135 24 ; ; : cord-010119-t1x9gknd 10135 25 however however RB cord-010119-t1x9gknd 10135 26 , , , cord-010119-t1x9gknd 10135 27 3 3 CD cord-010119-t1x9gknd 10135 28 assays assay NNS cord-010119-t1x9gknd 10135 29 were be VBD cord-010119-t1x9gknd 10135 30 identified identify VBN cord-010119-t1x9gknd 10135 31 for for IN cord-010119-t1x9gknd 10135 32 subsequent subsequent JJ cord-010119-t1x9gknd 10135 33 testing testing NN cord-010119-t1x9gknd 10135 34 as as IN cord-010119-t1x9gknd 10135 35 they -PRON- PRP cord-010119-t1x9gknd 10135 36 contain contain VBP cord-010119-t1x9gknd 10135 37 biotin biotin NN cord-010119-t1x9gknd 10135 38 in in IN cord-010119-t1x9gknd 10135 39 their -PRON- PRP$ cord-010119-t1x9gknd 10135 40 assay assay NN cord-010119-t1x9gknd 10135 41 design design NN cord-010119-t1x9gknd 10135 42 . . . cord-010119-t1x9gknd 10136 1 Background Background NNP cord-010119-t1x9gknd 10136 2 / / SYM cord-010119-t1x9gknd 10136 3 Case Case NNP cord-010119-t1x9gknd 10136 4 Studies Studies NNPS cord-010119-t1x9gknd 10136 5 : : : cord-010119-t1x9gknd 10137 1 Bacterial bacterial JJ cord-010119-t1x9gknd 10137 2 contamination contamination NN cord-010119-t1x9gknd 10137 3 of of IN cord-010119-t1x9gknd 10137 4 platelets platelet NNS cord-010119-t1x9gknd 10137 5 is be VBZ cord-010119-t1x9gknd 10137 6 the the DT cord-010119-t1x9gknd 10137 7 highest highest RBS cord-010119-t1x9gknd 10137 8 residual residual JJ cord-010119-t1x9gknd 10137 9 infectious infectious JJ cord-010119-t1x9gknd 10137 10 risk risk NN cord-010119-t1x9gknd 10137 11 in in IN cord-010119-t1x9gknd 10137 12 transfusion transfusion NN cord-010119-t1x9gknd 10137 13 despite despite IN cord-010119-t1x9gknd 10137 14 the the DT cord-010119-t1x9gknd 10137 15 current current JJ cord-010119-t1x9gknd 10137 16 preventive preventive JJ cord-010119-t1x9gknd 10137 17 strategies strategy NNS cord-010119-t1x9gknd 10137 18 . . . cord-010119-t1x9gknd 10138 1 While while IN cord-010119-t1x9gknd 10138 2 bacterial bacterial JJ cord-010119-t1x9gknd 10138 3 contamination contamination NN cord-010119-t1x9gknd 10138 4 may may MD cord-010119-t1x9gknd 10138 5 affect affect VB cord-010119-t1x9gknd 10138 6 any any DT cord-010119-t1x9gknd 10138 7 blood blood NN cord-010119-t1x9gknd 10138 8 component component NN cord-010119-t1x9gknd 10138 9 , , , cord-010119-t1x9gknd 10138 10 the the DT cord-010119-t1x9gknd 10138 11 ambient ambient JJ cord-010119-t1x9gknd 10138 12 storage storage NN cord-010119-t1x9gknd 10138 13 temperature temperature NN cord-010119-t1x9gknd 10138 14 conditions condition NNS cord-010119-t1x9gknd 10138 15 for for IN cord-010119-t1x9gknd 10138 16 platelets platelet NNS cord-010119-t1x9gknd 10138 17 make make VBP cord-010119-t1x9gknd 10138 18 them -PRON- PRP cord-010119-t1x9gknd 10138 19 most most RBS cord-010119-t1x9gknd 10138 20 likely likely JJ cord-010119-t1x9gknd 10138 21 to to TO cord-010119-t1x9gknd 10138 22 facilitate facilitate VB cord-010119-t1x9gknd 10138 23 bacterial bacterial JJ cord-010119-t1x9gknd 10138 24 growth growth NN cord-010119-t1x9gknd 10138 25 . . . cord-010119-t1x9gknd 10139 1 Based base VBN cord-010119-t1x9gknd 10139 2 on on IN cord-010119-t1x9gknd 10139 3 all all PDT cord-010119-t1x9gknd 10139 4 the the DT cord-010119-t1x9gknd 10139 5 precautionary precautionary JJ cord-010119-t1x9gknd 10139 6 measures measure NNS cord-010119-t1x9gknd 10139 7 , , , cord-010119-t1x9gknd 10139 8 the the DT cord-010119-t1x9gknd 10139 9 final final JJ cord-010119-t1x9gknd 10139 10 platelet platelet NN cord-010119-t1x9gknd 10139 11 concentrates concentrate NNS cord-010119-t1x9gknd 10139 12 include include VBP cord-010119-t1x9gknd 10139 13 in in IN cord-010119-t1x9gknd 10139 14 the the DT cord-010119-t1x9gknd 10139 15 worst bad JJS cord-010119-t1x9gknd 10139 16 cases case NNS cord-010119-t1x9gknd 10139 17 a a DT cord-010119-t1x9gknd 10139 18 very very RB cord-010119-t1x9gknd 10139 19 limited limited JJ cord-010119-t1x9gknd 10139 20 viable viable JJ cord-010119-t1x9gknd 10139 21 bacteria bacteria NNS cord-010119-t1x9gknd 10139 22 number number NN cord-010119-t1x9gknd 10139 23 estimated estimate VBN cord-010119-t1x9gknd 10139 24 from from IN cord-010119-t1x9gknd 10139 25 10 10 CD cord-010119-t1x9gknd 10139 26 to to TO cord-010119-t1x9gknd 10139 27 100 100 CD cord-010119-t1x9gknd 10139 28 colony colony NN cord-010119-t1x9gknd 10139 29 forming form VBG cord-010119-t1x9gknd 10139 30 units unit NNS cord-010119-t1x9gknd 10139 31 ( ( -LRB- cord-010119-t1x9gknd 10139 32 CFUs)/bag CFUs)/bag NNP cord-010119-t1x9gknd 10139 33 ( ( -LRB- cord-010119-t1x9gknd 10139 34 i.e. i.e. FW cord-010119-t1x9gknd 10139 35 0.03 0.03 CD cord-010119-t1x9gknd 10139 36 to to TO cord-010119-t1x9gknd 10139 37 0.3 0.3 CD cord-010119-t1x9gknd 10139 38 CFU CFU NNP cord-010119-t1x9gknd 10139 39 / / SYM cord-010119-t1x9gknd 10139 40 mL ml NN cord-010119-t1x9gknd 10139 41 ) ) -RRB- cord-010119-t1x9gknd 10139 42 . . . cord-010119-t1x9gknd 10140 1 One one CD cord-010119-t1x9gknd 10140 2 major major JJ cord-010119-t1x9gknd 10140 3 difference difference NN cord-010119-t1x9gknd 10140 4 between between IN cord-010119-t1x9gknd 10140 5 viruses virus NNS cord-010119-t1x9gknd 10140 6 and and CC cord-010119-t1x9gknd 10140 7 bacteria bacteria NNS cord-010119-t1x9gknd 10140 8 is be VBZ cord-010119-t1x9gknd 10140 9 that that IN cord-010119-t1x9gknd 10140 10 bacteria bacteria NNS cord-010119-t1x9gknd 10140 11 have have VBP cord-010119-t1x9gknd 10140 12 the the DT cord-010119-t1x9gknd 10140 13 ability ability NN cord-010119-t1x9gknd 10140 14 to to TO cord-010119-t1x9gknd 10140 15 grow grow VB cord-010119-t1x9gknd 10140 16 up up RP cord-010119-t1x9gknd 10140 17 to to IN cord-010119-t1x9gknd 10140 18 a a DT cord-010119-t1x9gknd 10140 19 concentration concentration NN cord-010119-t1x9gknd 10140 20 of of IN cord-010119-t1x9gknd 10140 21 10 10 CD cord-010119-t1x9gknd 10140 22 8 8 CD cord-010119-t1x9gknd 10140 23 -10 -10 CD cord-010119-t1x9gknd 10140 24 9 9 CD cord-010119-t1x9gknd 10140 25 CFU CFU NNP cord-010119-t1x9gknd 10140 26 / / SYM cord-010119-t1x9gknd 10140 27 mL ml NN cord-010119-t1x9gknd 10140 28 over over IN cord-010119-t1x9gknd 10140 29 the the DT cord-010119-t1x9gknd 10140 30 5 5 CD cord-010119-t1x9gknd 10140 31 days day NNS cord-010119-t1x9gknd 10140 32 product product NN cord-010119-t1x9gknd 10140 33 shelf shelf NN cord-010119-t1x9gknd 10140 34 - - HYPH cord-010119-t1x9gknd 10140 35 life life NN cord-010119-t1x9gknd 10140 36 . . . cord-010119-t1x9gknd 10141 1 Moreover moreover RB cord-010119-t1x9gknd 10141 2 , , , cord-010119-t1x9gknd 10141 3 a a DT cord-010119-t1x9gknd 10141 4 large large JJ cord-010119-t1x9gknd 10141 5 diversity diversity NN cord-010119-t1x9gknd 10141 6 of of IN cord-010119-t1x9gknd 10141 7 strains strain NNS cord-010119-t1x9gknd 10141 8 is be VBZ cord-010119-t1x9gknd 10141 9 found find VBN cord-010119-t1x9gknd 10141 10 in in IN cord-010119-t1x9gknd 10141 11 contaminated contaminated JJ cord-010119-t1x9gknd 10141 12 platelets platelet NNS cord-010119-t1x9gknd 10141 13 representing represent VBG cord-010119-t1x9gknd 10141 14 a a DT cord-010119-t1x9gknd 10141 15 key key JJ cord-010119-t1x9gknd 10141 16 challenge challenge NN cord-010119-t1x9gknd 10141 17 for for IN cord-010119-t1x9gknd 10141 18 the the DT cord-010119-t1x9gknd 10141 19 development development NN cord-010119-t1x9gknd 10141 20 of of IN cord-010119-t1x9gknd 10141 21 a a DT cord-010119-t1x9gknd 10141 22 generic generic JJ cord-010119-t1x9gknd 10141 23 bacterial bacterial JJ cord-010119-t1x9gknd 10141 24 test test NN cord-010119-t1x9gknd 10141 25 . . . cord-010119-t1x9gknd 10142 1 The the DT cord-010119-t1x9gknd 10142 2 aim aim NN cord-010119-t1x9gknd 10142 3 of of IN cord-010119-t1x9gknd 10142 4 this this DT cord-010119-t1x9gknd 10142 5 study study NN cord-010119-t1x9gknd 10142 6 was be VBD cord-010119-t1x9gknd 10142 7 to to TO cord-010119-t1x9gknd 10142 8 develop develop VB cord-010119-t1x9gknd 10142 9 an an DT cord-010119-t1x9gknd 10142 10 economic economic JJ cord-010119-t1x9gknd 10142 11 and and CC cord-010119-t1x9gknd 10142 12 easy easy JJ cord-010119-t1x9gknd 10142 13 diagnostic diagnostic JJ cord-010119-t1x9gknd 10142 14 approach approach NN cord-010119-t1x9gknd 10142 15 for for IN cord-010119-t1x9gknd 10142 16 the the DT cord-010119-t1x9gknd 10142 17 early early JJ cord-010119-t1x9gknd 10142 18 , , , cord-010119-t1x9gknd 10142 19 rapid rapid JJ cord-010119-t1x9gknd 10142 20 , , , cord-010119-t1x9gknd 10142 21 sensitive sensitive JJ cord-010119-t1x9gknd 10142 22 and and CC cord-010119-t1x9gknd 10142 23 generic generic JJ cord-010119-t1x9gknd 10142 24 detection detection NN cord-010119-t1x9gknd 10142 25 of of IN cord-010119-t1x9gknd 10142 26 bacteria bacteria NNS cord-010119-t1x9gknd 10142 27 in in IN cord-010119-t1x9gknd 10142 28 platelet platelet NN cord-010119-t1x9gknd 10142 29 concentrates concentrate NNS cord-010119-t1x9gknd 10142 30 . . . cord-010119-t1x9gknd 10143 1 The the DT cord-010119-t1x9gknd 10143 2 adaptability adaptability NN cord-010119-t1x9gknd 10143 3 of of IN cord-010119-t1x9gknd 10143 4 the the DT cord-010119-t1x9gknd 10143 5 process process NN cord-010119-t1x9gknd 10143 6 with with IN cord-010119-t1x9gknd 10143 7 the the DT cord-010119-t1x9gknd 10143 8 blood blood NN cord-010119-t1x9gknd 10143 9 transfusion transfusion NN cord-010119-t1x9gknd 10143 10 services service NNS cord-010119-t1x9gknd 10143 11 requirements requirement NNS cord-010119-t1x9gknd 10143 12 was be VBD cord-010119-t1x9gknd 10143 13 of of IN cord-010119-t1x9gknd 10143 14 major major JJ cord-010119-t1x9gknd 10143 15 concern concern NN cord-010119-t1x9gknd 10143 16 . . . cord-010119-t1x9gknd 10144 1 Hence hence RB cord-010119-t1x9gknd 10144 2 , , , cord-010119-t1x9gknd 10144 3 attention attention NN cord-010119-t1x9gknd 10144 4 was be VBD cord-010119-t1x9gknd 10144 5 focused focus VBN cord-010119-t1x9gknd 10144 6 on on IN cord-010119-t1x9gknd 10144 7 an an DT cord-010119-t1x9gknd 10144 8 easy easy NN cord-010119-t1x9gknd 10144 9 to to TO cord-010119-t1x9gknd 10144 10 automate automate VB cord-010119-t1x9gknd 10144 11 technique technique NN cord-010119-t1x9gknd 10144 12 able able JJ cord-010119-t1x9gknd 10144 13 to to TO cord-010119-t1x9gknd 10144 14 deliver deliver VB cord-010119-t1x9gknd 10144 15 results result NNS cord-010119-t1x9gknd 10144 16 on on IN cord-010119-t1x9gknd 10144 17 Day day NN cord-010119-t1x9gknd 10144 18 2 2 CD cord-010119-t1x9gknd 10144 19 after after IN cord-010119-t1x9gknd 10144 20 collection collection NN cord-010119-t1x9gknd 10144 21 . . . cord-010119-t1x9gknd 10145 1 Study Study NNP cord-010119-t1x9gknd 10145 2 Design Design NNP cord-010119-t1x9gknd 10145 3 / / SYM cord-010119-t1x9gknd 10145 4 Method method NN cord-010119-t1x9gknd 10145 5 : : : cord-010119-t1x9gknd 10146 1 A a DT cord-010119-t1x9gknd 10146 2 large large JJ cord-010119-t1x9gknd 10146 3 panel panel NN cord-010119-t1x9gknd 10146 4 of of IN cord-010119-t1x9gknd 10146 5 bacteria bacteria NNS cord-010119-t1x9gknd 10146 6 involved involve VBN cord-010119-t1x9gknd 10146 7 in in IN cord-010119-t1x9gknd 10146 8 transfusion transfusion NN cord-010119-t1x9gknd 10146 9 reactions reaction NNS cord-010119-t1x9gknd 10146 10 including include VBG cord-010119-t1x9gknd 10146 11 clinical clinical JJ cord-010119-t1x9gknd 10146 12 isolates isolate NNS cord-010119-t1x9gknd 10146 13 and and CC cord-010119-t1x9gknd 10146 14 reference reference NN cord-010119-t1x9gknd 10146 15 strains strain NNS cord-010119-t1x9gknd 10146 16 was be VBD cord-010119-t1x9gknd 10146 17 established establish VBN cord-010119-t1x9gknd 10146 18 and and CC cord-010119-t1x9gknd 10146 19 used use VBN cord-010119-t1x9gknd 10146 20 for for IN cord-010119-t1x9gknd 10146 21 mouse mouse NN cord-010119-t1x9gknd 10146 22 immunizations immunization NNS cord-010119-t1x9gknd 10146 23 , , , cord-010119-t1x9gknd 10146 24 antibody antibody NN cord-010119-t1x9gknd 10146 25 screening screening NN cord-010119-t1x9gknd 10146 26 and and CC cord-010119-t1x9gknd 10146 27 platelet platelet NN cord-010119-t1x9gknd 10146 28 spiking spiking NN cord-010119-t1x9gknd 10146 29 steps step NNS cord-010119-t1x9gknd 10146 30 . . . cord-010119-t1x9gknd 10147 1 An an DT cord-010119-t1x9gknd 10147 2 original original JJ cord-010119-t1x9gknd 10147 3 approach approach NN cord-010119-t1x9gknd 10147 4 was be VBD cord-010119-t1x9gknd 10147 5 used use VBN cord-010119-t1x9gknd 10147 6 to to TO cord-010119-t1x9gknd 10147 7 produce produce VB cord-010119-t1x9gknd 10147 8 and and CC cord-010119-t1x9gknd 10147 9 select select VB cord-010119-t1x9gknd 10147 10 monoclonal monoclonal JJ cord-010119-t1x9gknd 10147 11 antibodies antibody NNS cord-010119-t1x9gknd 10147 12 directed direct VBN cord-010119-t1x9gknd 10147 13 against against IN cord-010119-t1x9gknd 10147 14 bacteria bacteria NNS cord-010119-t1x9gknd 10147 15 to to TO cord-010119-t1x9gknd 10147 16 develop develop VB cord-010119-t1x9gknd 10147 17 our -PRON- PRP$ cord-010119-t1x9gknd 10147 18 generic generic JJ cord-010119-t1x9gknd 10147 19 immunoassay immunoassay NN cord-010119-t1x9gknd 10147 20 . . . cord-010119-t1x9gknd 10148 1 As as IN cord-010119-t1x9gknd 10148 2 recommended recommend VBN cord-010119-t1x9gknd 10148 3 , , , cord-010119-t1x9gknd 10148 4 24 24 CD cord-010119-t1x9gknd 10148 5 hours hour NNS cord-010119-t1x9gknd 10148 6 ( ( -LRB- cord-010119-t1x9gknd 10148 7 Day day NN cord-010119-t1x9gknd 10148 8 1 1 CD cord-010119-t1x9gknd 10148 9 ) ) -RRB- cord-010119-t1x9gknd 10148 10 after after IN cord-010119-t1x9gknd 10148 11 collection collection NN cord-010119-t1x9gknd 10149 1 a a DT cord-010119-t1x9gknd 10149 2 sampling sampling NN cord-010119-t1x9gknd 10149 3 volume volume NN cord-010119-t1x9gknd 10149 4 of of IN cord-010119-t1x9gknd 10149 5 spiked spiked JJ cord-010119-t1x9gknd 10149 6 platelets platelet NNS cord-010119-t1x9gknd 10149 7 ( ( -LRB- cord-010119-t1x9gknd 10149 8 0.1 0.1 CD cord-010119-t1x9gknd 10149 9 - - SYM cord-010119-t1x9gknd 10149 10 1 1 CD cord-010119-t1x9gknd 10149 11 CFU CFU NNP cord-010119-t1x9gknd 10149 12 / / SYM cord-010119-t1x9gknd 10149 13 ml ml NN cord-010119-t1x9gknd 10149 14 ) ) -RRB- cord-010119-t1x9gknd 10149 15 was be VBD cord-010119-t1x9gknd 10149 16 tested test VBN cord-010119-t1x9gknd 10149 17 after after IN cord-010119-t1x9gknd 10149 18 a a DT cord-010119-t1x9gknd 10149 19 short short JJ cord-010119-t1x9gknd 10149 20 generic generic JJ cord-010119-t1x9gknd 10149 21 culture culture NN cord-010119-t1x9gknd 10149 22 , , , cord-010119-t1x9gknd 10149 23 lysis lysis NN cord-010119-t1x9gknd 10149 24 and and CC cord-010119-t1x9gknd 10149 25 capture capture NN cord-010119-t1x9gknd 10149 26 of of IN cord-010119-t1x9gknd 10149 27 bacteria bacteria NNS cord-010119-t1x9gknd 10149 28 on on IN cord-010119-t1x9gknd 10149 29 magnetic magnetic JJ cord-010119-t1x9gknd 10149 30 microparticles microparticle NNS cord-010119-t1x9gknd 10149 31 in in IN cord-010119-t1x9gknd 10149 32 a a DT cord-010119-t1x9gknd 10149 33 microplate microplate JJ cord-010119-t1x9gknd 10149 34 format format NN cord-010119-t1x9gknd 10149 35 . . . cord-010119-t1x9gknd 10150 1 An an DT cord-010119-t1x9gknd 10150 2 immunoassay immunoassay NN cord-010119-t1x9gknd 10150 3 was be VBD cord-010119-t1x9gknd 10150 4 performed perform VBN cord-010119-t1x9gknd 10150 5 for for IN cord-010119-t1x9gknd 10150 6 the the DT cord-010119-t1x9gknd 10150 7 detection detection NN cord-010119-t1x9gknd 10150 8 of of IN cord-010119-t1x9gknd 10150 9 the the DT cord-010119-t1x9gknd 10150 10 captured capture VBN cord-010119-t1x9gknd 10150 11 bacteria bacteria NNS cord-010119-t1x9gknd 10150 12 . . . cord-010119-t1x9gknd 10151 1 Results/ Results/ . cord-010119-t1x9gknd 10152 1 Finding finding NN cord-010119-t1x9gknd 10152 2 : : : cord-010119-t1x9gknd 10153 1 This this DT cord-010119-t1x9gknd 10153 2 approach approach NN cord-010119-t1x9gknd 10153 3 was be VBD cord-010119-t1x9gknd 10153 4 tested test VBN cord-010119-t1x9gknd 10153 5 on on IN cord-010119-t1x9gknd 10153 6 a a DT cord-010119-t1x9gknd 10153 7 panel panel NN cord-010119-t1x9gknd 10153 8 of of IN cord-010119-t1x9gknd 10153 9 25 25 CD cord-010119-t1x9gknd 10153 10 bacterial bacterial JJ cord-010119-t1x9gknd 10153 11 strains strain NNS cord-010119-t1x9gknd 10153 12 involved involve VBN cord-010119-t1x9gknd 10153 13 in in IN cord-010119-t1x9gknd 10153 14 transfusion transfusion NN cord-010119-t1x9gknd 10153 15 reactions reaction NNS cord-010119-t1x9gknd 10153 16 . . . cord-010119-t1x9gknd 10154 1 The the DT cord-010119-t1x9gknd 10154 2 pre pre JJ cord-010119-t1x9gknd 10154 3 - - JJ cord-010119-t1x9gknd 10154 4 analytical analytical JJ cord-010119-t1x9gknd 10154 5 steps step NNS cord-010119-t1x9gknd 10154 6 and and CC cord-010119-t1x9gknd 10154 7 the the DT cord-010119-t1x9gknd 10154 8 capture capture NN cord-010119-t1x9gknd 10154 9 of of IN cord-010119-t1x9gknd 10154 10 bacteria bacteria NNS cord-010119-t1x9gknd 10154 11 on on IN cord-010119-t1x9gknd 10154 12 microparticles microparticle NNS cord-010119-t1x9gknd 10154 13 were be VBD cord-010119-t1x9gknd 10154 14 improved improve VBN cord-010119-t1x9gknd 10154 15 to to TO cord-010119-t1x9gknd 10154 16 avoid avoid VB cord-010119-t1x9gknd 10154 17 false false JJ cord-010119-t1x9gknd 10154 18 negative negative JJ cord-010119-t1x9gknd 10154 19 results result NNS cord-010119-t1x9gknd 10154 20 and and CC cord-010119-t1x9gknd 10154 21 to to TO cord-010119-t1x9gknd 10154 22 enhance enhance VB cord-010119-t1x9gknd 10154 23 the the DT cord-010119-t1x9gknd 10154 24 sensitivity sensitivity NN cord-010119-t1x9gknd 10154 25 of of IN cord-010119-t1x9gknd 10154 26 detection detection NN cord-010119-t1x9gknd 10154 27 . . . cord-010119-t1x9gknd 10155 1 The the DT cord-010119-t1x9gknd 10155 2 full full JJ cord-010119-t1x9gknd 10155 3 test test NN cord-010119-t1x9gknd 10155 4 developed develop VBN cord-010119-t1x9gknd 10155 5 in in IN cord-010119-t1x9gknd 10155 6 this this DT cord-010119-t1x9gknd 10155 7 study study NN cord-010119-t1x9gknd 10155 8 combining combine VBG cord-010119-t1x9gknd 10155 9 a a DT cord-010119-t1x9gknd 10155 10 pre pre JJ cord-010119-t1x9gknd 10155 11 - - JJ cord-010119-t1x9gknd 10155 12 analytical analytical JJ cord-010119-t1x9gknd 10155 13 culture culture NN cord-010119-t1x9gknd 10155 14 step step NN cord-010119-t1x9gknd 10155 15 followed follow VBN cord-010119-t1x9gknd 10155 16 by by IN cord-010119-t1x9gknd 10155 17 an an DT cord-010119-t1x9gknd 10155 18 There there EX cord-010119-t1x9gknd 10155 19 are be VBP cord-010119-t1x9gknd 10155 20 many many JJ cord-010119-t1x9gknd 10155 21 stakeholders stakeholder NNS cord-010119-t1x9gknd 10155 22 are be VBP cord-010119-t1x9gknd 10155 23 involved involve VBN cord-010119-t1x9gknd 10155 24 in in IN cord-010119-t1x9gknd 10155 25 HCV HCV NNP cord-010119-t1x9gknd 10155 26 eradication eradication NN cord-010119-t1x9gknd 10155 27 program program NN cord-010119-t1x9gknd 10155 28 , , , cord-010119-t1x9gknd 10155 29 including include VBG cord-010119-t1x9gknd 10155 30 government government NN cord-010119-t1x9gknd 10155 31 authority authority NN cord-010119-t1x9gknd 10155 32 such such JJ cord-010119-t1x9gknd 10155 33 as as IN cord-010119-t1x9gknd 10155 34 Centers Centers NNPS cord-010119-t1x9gknd 10155 35 for for IN cord-010119-t1x9gknd 10155 36 Disease Disease NNP cord-010119-t1x9gknd 10155 37 Control Control NNP cord-010119-t1x9gknd 10155 38 and and CC cord-010119-t1x9gknd 10155 39 Prevention Prevention NNP cord-010119-t1x9gknd 10155 40 , , , cord-010119-t1x9gknd 10155 41 National National NNP cord-010119-t1x9gknd 10155 42 Health Health NNP cord-010119-t1x9gknd 10155 43 Insurance Insurance NNP cord-010119-t1x9gknd 10155 44 and and CC cord-010119-t1x9gknd 10155 45 Health Health NNP cord-010119-t1x9gknd 10155 46 Promotion Promotion NNP cord-010119-t1x9gknd 10155 47 Administration Administration NNP cord-010119-t1x9gknd 10155 48 , , , cord-010119-t1x9gknd 10155 49 and and CC cord-010119-t1x9gknd 10155 50 private private JJ cord-010119-t1x9gknd 10155 51 property property NN cord-010119-t1x9gknd 10155 52 like like IN cord-010119-t1x9gknd 10155 53 hospitals hospital NNS cord-010119-t1x9gknd 10155 54 , , , cord-010119-t1x9gknd 10155 55 medical medical JJ cord-010119-t1x9gknd 10155 56 societies society NNS cord-010119-t1x9gknd 10155 57 , , , cord-010119-t1x9gknd 10155 58 pharmaceutical pharmaceutical NN cord-010119-t1x9gknd 10155 59 and and CC cord-010119-t1x9gknd 10155 60 vaccine vaccine NN cord-010119-t1x9gknd 10155 61 industries industry NNS cord-010119-t1x9gknd 10155 62 , , , cord-010119-t1x9gknd 10155 63 NPOs npo NNS cord-010119-t1x9gknd 10155 64 and and CC cord-010119-t1x9gknd 10155 65 academia academia NN cord-010119-t1x9gknd 10155 66 . . . cord-010119-t1x9gknd 10156 1 Results/ Results/ . cord-010119-t1x9gknd 10157 1 Finding find VBG cord-010119-t1x9gknd 10157 2 : : : cord-010119-t1x9gknd 10157 3 TBSF TBSF NNP cord-010119-t1x9gknd 10157 4 is be VBZ cord-010119-t1x9gknd 10157 5 a a DT cord-010119-t1x9gknd 10157 6 private private JJ cord-010119-t1x9gknd 10157 7 nationwide nationwide JJ cord-010119-t1x9gknd 10157 8 single single JJ cord-010119-t1x9gknd 10157 9 blood blood NN cord-010119-t1x9gknd 10157 10 services service NNS cord-010119-t1x9gknd 10157 11 program program NN cord-010119-t1x9gknd 10157 12 in in IN cord-010119-t1x9gknd 10157 13 Taiwan Taiwan NNP cord-010119-t1x9gknd 10157 14 , , , cord-010119-t1x9gknd 10157 15 and and CC cord-010119-t1x9gknd 10157 16 performs perform VBZ cord-010119-t1x9gknd 10157 17 Anti Anti NNP cord-010119-t1x9gknd 10157 18 - - JJ cord-010119-t1x9gknd 10157 19 HCV HCV NNP cord-010119-t1x9gknd 10157 20 screening screening NN cord-010119-t1x9gknd 10157 21 test test NN cord-010119-t1x9gknd 10157 22 and and CC cord-010119-t1x9gknd 10157 23 NAT NAT NNP cord-010119-t1x9gknd 10157 24 confirmatory confirmatory JJ cord-010119-t1x9gknd 10157 25 test test NN cord-010119-t1x9gknd 10157 26 on on IN cord-010119-t1x9gknd 10157 27 every every DT cord-010119-t1x9gknd 10157 28 collected collect VBN cord-010119-t1x9gknd 10157 29 blood blood NN cord-010119-t1x9gknd 10157 30 , , , cord-010119-t1x9gknd 10157 31 which which WDT cord-010119-t1x9gknd 10157 32 is be VBZ cord-010119-t1x9gknd 10157 33 a a DT cord-010119-t1x9gknd 10157 34 large large JJ cord-010119-t1x9gknd 10157 35 - - HYPH cord-010119-t1x9gknd 10157 36 scale scale NN cord-010119-t1x9gknd 10157 37 population population NN cord-010119-t1x9gknd 10157 38 screening screening NN cord-010119-t1x9gknd 10157 39 of of IN cord-010119-t1x9gknd 10157 40 HCV HCV NNP cord-010119-t1x9gknd 10157 41 in in IN cord-010119-t1x9gknd 10157 42 Taiwan Taiwan NNP cord-010119-t1x9gknd 10157 43 because because IN cord-010119-t1x9gknd 10157 44 of of IN cord-010119-t1x9gknd 10157 45 its -PRON- PRP$ cord-010119-t1x9gknd 10157 46 high high JJ cord-010119-t1x9gknd 10157 47 blood blood NN cord-010119-t1x9gknd 10157 48 donation donation NN cord-010119-t1x9gknd 10157 49 rate rate NN cord-010119-t1x9gknd 10157 50 ( ( -LRB- cord-010119-t1x9gknd 10157 51 7.5 7.5 CD cord-010119-t1x9gknd 10157 52 % % NN cord-010119-t1x9gknd 10157 53 ) ) -RRB- cord-010119-t1x9gknd 10157 54 . . . cord-010119-t1x9gknd 10158 1 TBSF TBSF NNP cord-010119-t1x9gknd 10158 2 confirmed confirm VBD cord-010119-t1x9gknd 10158 3 positive positive JJ cord-010119-t1x9gknd 10158 4 test test NN cord-010119-t1x9gknd 10158 5 result result NN cord-010119-t1x9gknd 10158 6 of of IN cord-010119-t1x9gknd 10158 7 repeated repeat VBN cord-010119-t1x9gknd 10158 8 blood blood NN cord-010119-t1x9gknd 10158 9 donors donor NNS cord-010119-t1x9gknd 10158 10 , , , cord-010119-t1x9gknd 10158 11 and and CC cord-010119-t1x9gknd 10158 12 can can MD cord-010119-t1x9gknd 10158 13 identify identify VB cord-010119-t1x9gknd 10158 14 HCV HCV NNP cord-010119-t1x9gknd 10158 15 RNA RNA NNP cord-010119-t1x9gknd 10158 16 seroconversion seroconversion NN cord-010119-t1x9gknd 10158 17 cases case NNS cord-010119-t1x9gknd 10158 18 as as IN cord-010119-t1x9gknd 10158 19 recently recently RB cord-010119-t1x9gknd 10158 20 - - HYPH cord-010119-t1x9gknd 10158 21 infected infect VBN cord-010119-t1x9gknd 10158 22 hepatitis hepatitis NN cord-010119-t1x9gknd 10158 23 patients patient NNS cord-010119-t1x9gknd 10158 24 . . . cord-010119-t1x9gknd 10159 1 Those those DT cord-010119-t1x9gknd 10159 2 infected infect VBN cord-010119-t1x9gknd 10159 3 patients patient NNS cord-010119-t1x9gknd 10159 4 would would MD cord-010119-t1x9gknd 10159 5 be be VB cord-010119-t1x9gknd 10159 6 referred refer VBN cord-010119-t1x9gknd 10159 7 to to IN cord-010119-t1x9gknd 10159 8 physician physician VB cord-010119-t1x9gknd 10159 9 for for IN cord-010119-t1x9gknd 10159 10 further further JJ cord-010119-t1x9gknd 10159 11 medical medical JJ cord-010119-t1x9gknd 10159 12 care care NN cord-010119-t1x9gknd 10159 13 and and CC cord-010119-t1x9gknd 10159 14 deferred defer VBD cord-010119-t1x9gknd 10159 15 permanently permanently RB cord-010119-t1x9gknd 10159 16 by by IN cord-010119-t1x9gknd 10159 17 TBSF TBSF NNP cord-010119-t1x9gknd 10159 18 to to TO cord-010119-t1x9gknd 10159 19 secure secure VB cord-010119-t1x9gknd 10159 20 blood blood NN cord-010119-t1x9gknd 10159 21 safety safety NN cord-010119-t1x9gknd 10159 22 . . . cord-010119-t1x9gknd 10160 1 By by IN cord-010119-t1x9gknd 10160 2 interviewing interview VBG cord-010119-t1x9gknd 10160 3 the the DT cord-010119-t1x9gknd 10160 4 newly newly RB cord-010119-t1x9gknd 10160 5 - - HYPH cord-010119-t1x9gknd 10160 6 infected infect VBN cord-010119-t1x9gknd 10160 7 cases case NNS cord-010119-t1x9gknd 10160 8 , , , cord-010119-t1x9gknd 10160 9 the the DT cord-010119-t1x9gknd 10160 10 risk risk NN cord-010119-t1x9gknd 10160 11 factors factor NNS cord-010119-t1x9gknd 10160 12 of of IN cord-010119-t1x9gknd 10160 13 HCV HCV NNP cord-010119-t1x9gknd 10160 14 patients patient NNS cord-010119-t1x9gknd 10160 15 can can MD cord-010119-t1x9gknd 10160 16 be be VB cord-010119-t1x9gknd 10160 17 studied study VBN cord-010119-t1x9gknd 10160 18 and and CC cord-010119-t1x9gknd 10160 19 then then RB cord-010119-t1x9gknd 10160 20 help help VB cord-010119-t1x9gknd 10160 21 identifying identify VBG cord-010119-t1x9gknd 10160 22 and and CC cord-010119-t1x9gknd 10160 23 eliminating eliminate VBG cord-010119-t1x9gknd 10160 24 sources source NNS cord-010119-t1x9gknd 10160 25 of of IN cord-010119-t1x9gknd 10160 26 HCV HCV NNP cord-010119-t1x9gknd 10160 27 infection infection NN cord-010119-t1x9gknd 10160 28 . . . cord-010119-t1x9gknd 10161 1 TBSF TBSF NNP cord-010119-t1x9gknd 10161 2 also also RB cord-010119-t1x9gknd 10161 3 contribute contribute VBP cord-010119-t1x9gknd 10161 4 to to IN cord-010119-t1x9gknd 10161 5 health health NN cord-010119-t1x9gknd 10161 6 education education NN cord-010119-t1x9gknd 10161 7 by by IN cord-010119-t1x9gknd 10161 8 teaching teach VBG cord-010119-t1x9gknd 10161 9 our -PRON- PRP$ cord-010119-t1x9gknd 10161 10 donors donor NNS cord-010119-t1x9gknd 10161 11 being be VBG cord-010119-t1x9gknd 10161 12 aware aware JJ cord-010119-t1x9gknd 10161 13 of of IN cord-010119-t1x9gknd 10161 14 potential potential JJ cord-010119-t1x9gknd 10161 15 risks risk NNS cord-010119-t1x9gknd 10161 16 of of IN cord-010119-t1x9gknd 10161 17 HCV HCV NNP cord-010119-t1x9gknd 10161 18 infection infection NN cord-010119-t1x9gknd 10161 19 and and CC cord-010119-t1x9gknd 10161 20 keep keep VB cord-010119-t1x9gknd 10161 21 monitoring monitor VBG cord-010119-t1x9gknd 10161 22 every every DT cord-010119-t1x9gknd 10161 23 parameters parameter NNS cord-010119-t1x9gknd 10161 24 of of IN cord-010119-t1x9gknd 10161 25 HCV HCV NNP cord-010119-t1x9gknd 10161 26 epidemiology epidemiology NN cord-010119-t1x9gknd 10161 27 to to TO cord-010119-t1x9gknd 10161 28 evaluate evaluate VB cord-010119-t1x9gknd 10161 29 the the DT cord-010119-t1x9gknd 10161 30 efficacy efficacy NN cord-010119-t1x9gknd 10161 31 of of IN cord-010119-t1x9gknd 10161 32 HCV HCV NNP cord-010119-t1x9gknd 10161 33 eradication eradication NN cord-010119-t1x9gknd 10161 34 program program NN cord-010119-t1x9gknd 10161 35 . . . cord-010119-t1x9gknd 10162 1 Conclusion conclusion NN cord-010119-t1x9gknd 10162 2 : : : cord-010119-t1x9gknd 10163 1 In in IN cord-010119-t1x9gknd 10163 2 HCV HCV NNP cord-010119-t1x9gknd 10163 3 eradication eradication NN cord-010119-t1x9gknd 10163 4 program program NN cord-010119-t1x9gknd 10163 5 , , , cord-010119-t1x9gknd 10163 6 TBSF TBSF NNP cord-010119-t1x9gknd 10163 7 can can MD cord-010119-t1x9gknd 10163 8 not not RB cord-010119-t1x9gknd 10163 9 only only RB cord-010119-t1x9gknd 10163 10 secure secure VB cord-010119-t1x9gknd 10163 11 blood blood NN cord-010119-t1x9gknd 10163 12 safety safety NN cord-010119-t1x9gknd 10163 13 but but CC cord-010119-t1x9gknd 10163 14 also also RB cord-010119-t1x9gknd 10163 15 participate participate VB cord-010119-t1x9gknd 10163 16 in in IN cord-010119-t1x9gknd 10163 17 health health NN cord-010119-t1x9gknd 10163 18 education education NN cord-010119-t1x9gknd 10163 19 , , , cord-010119-t1x9gknd 10163 20 disease disease NN cord-010119-t1x9gknd 10163 21 screening screening NN cord-010119-t1x9gknd 10163 22 , , , cord-010119-t1x9gknd 10163 23 etiology etiology NN cord-010119-t1x9gknd 10163 24 finding finding NN cord-010119-t1x9gknd 10163 25 and and CC cord-010119-t1x9gknd 10163 26 prevention prevention NN cord-010119-t1x9gknd 10163 27 , , , cord-010119-t1x9gknd 10163 28 surveillance surveillance NN cord-010119-t1x9gknd 10163 29 and and CC cord-010119-t1x9gknd 10163 30 evaluation evaluation NN cord-010119-t1x9gknd 10163 31 . . . cord-010119-t1x9gknd 10164 1 Thus thus RB cord-010119-t1x9gknd 10164 2 , , , cord-010119-t1x9gknd 10164 3 among among IN cord-010119-t1x9gknd 10164 4 all all DT cord-010119-t1x9gknd 10164 5 stakeholders stakeholder NNS cord-010119-t1x9gknd 10164 6 , , , cord-010119-t1x9gknd 10164 7 TBSF TBSF NNP cord-010119-t1x9gknd 10164 8 is be VBZ cord-010119-t1x9gknd 10164 9 particularly particularly RB cord-010119-t1x9gknd 10164 10 important important JJ cord-010119-t1x9gknd 10164 11 and and CC cord-010119-t1x9gknd 10164 12 can can MD cord-010119-t1x9gknd 10164 13 play play VB cord-010119-t1x9gknd 10164 14 a a DT cord-010119-t1x9gknd 10164 15 pivotal pivotal JJ cord-010119-t1x9gknd 10164 16 role role NN cord-010119-t1x9gknd 10164 17 in in IN cord-010119-t1x9gknd 10164 18 eradicating eradicate VBG cord-010119-t1x9gknd 10164 19 HCV HCV NNP cord-010119-t1x9gknd 10164 20 by by IN cord-010119-t1x9gknd 10164 21 2030 2030 CD cord-010119-t1x9gknd 10164 22 in in IN cord-010119-t1x9gknd 10164 23 Taiwan Taiwan NNP cord-010119-t1x9gknd 10164 24 . . . cord-010119-t1x9gknd 10165 1 The the DT cord-010119-t1x9gknd 10165 2 Theraflex Theraflex NNP cord-010119-t1x9gknd 10165 3 UV uv NN cord-010119-t1x9gknd 10165 4 - - HYPH cord-010119-t1x9gknd 10165 5 Platelets platelets NN cord-010119-t1x9gknd 10165 6 Technology technology NN cord-010119-t1x9gknd 10165 7 Efficiently efficiently RB cord-010119-t1x9gknd 10165 8 Inactivates Inactivates NNPS cord-010119-t1x9gknd 10166 1 Transfusion transfusion NN cord-010119-t1x9gknd 10166 2 - - HYPH cord-010119-t1x9gknd 10166 3 Relevant relevant JJ cord-010119-t1x9gknd 10166 4 Bacteria Bacteria NNS cord-010119-t1x9gknd 10166 5 Species specie NNS cord-010119-t1x9gknd 10166 6 in in IN cord-010119-t1x9gknd 10166 7 Contaminated Contaminated NNP cord-010119-t1x9gknd 10166 8 Platelet platelet NN cord-010119-t1x9gknd 10166 9 Concentrates concentrate VBZ cord-010119-t1x9gknd 10166 10 Ute Ute NNP cord-010119-t1x9gknd 10166 11 Gravemann Gravemann NNP cord-010119-t1x9gknd 10166 12 1 1 CD cord-010119-t1x9gknd 10166 13 , , , cord-010119-t1x9gknd 10166 14 Frank Frank NNP cord-010119-t1x9gknd 10166 15 Tolksdorf Tolksdorf NNP cord-010119-t1x9gknd 10166 16 2 2 CD cord-010119-t1x9gknd 10166 17 , , , cord-010119-t1x9gknd 10166 18 Wiebke Wiebke NNP cord-010119-t1x9gknd 10166 19 Handke Handke NNP cord-010119-t1x9gknd 10166 20 1 1 CD cord-010119-t1x9gknd 10167 1 , , , cord-010119-t1x9gknd 10167 2 Thomas Thomas NNP cord-010119-t1x9gknd 10167 3 H. H. NNP cord-010119-t1x9gknd 10167 4 M€ M€ NNP cord-010119-t1x9gknd 10167 5 uller uller NNP cord-010119-t1x9gknd 10167 6 1 1 NNP cord-010119-t1x9gknd 10167 7 and and CC cord-010119-t1x9gknd 10167 8 Axel Axel NNP cord-010119-t1x9gknd 10167 9 Seltsam Seltsam NNP cord-010119-t1x9gknd 10167 10 * * NFP cord-010119-t1x9gknd 10167 11 1 1 CD cord-010119-t1x9gknd 10167 12 . . . cord-010119-t1x9gknd 10168 1 1 1 CD cord-010119-t1x9gknd 10168 2 German German NNP cord-010119-t1x9gknd 10168 3 Red Red NNP cord-010119-t1x9gknd 10168 4 Cross Cross NNP cord-010119-t1x9gknd 10168 5 Blood Blood NNP cord-010119-t1x9gknd 10168 6 Service Service NNP cord-010119-t1x9gknd 10168 7 NSTOB NSTOB NNP cord-010119-t1x9gknd 10168 8 , , , cord-010119-t1x9gknd 10168 9 2 2 CD cord-010119-t1x9gknd 10168 10 Maco Maco NNP cord-010119-t1x9gknd 10168 11 Pharma Pharma NNP cord-010119-t1x9gknd 10168 12 International International NNP cord-010119-t1x9gknd 10168 13 , , , cord-010119-t1x9gknd 10168 14 GMBH GMBH NNP cord-010119-t1x9gknd 10168 15 Background Background NNP cord-010119-t1x9gknd 10168 16 / / SYM cord-010119-t1x9gknd 10168 17 Case Case NNP cord-010119-t1x9gknd 10168 18 Studies Studies NNPS cord-010119-t1x9gknd 10168 19 : : : cord-010119-t1x9gknd 10169 1 The the DT cord-010119-t1x9gknd 10169 2 THERAFLEX THERAFLEX NNP cord-010119-t1x9gknd 10169 3 UV uv NN cord-010119-t1x9gknd 10169 4 - - HYPH cord-010119-t1x9gknd 10169 5 Platelets platelet NNS cord-010119-t1x9gknd 10169 6 system system NN cord-010119-t1x9gknd 10169 7 ( ( -LRB- cord-010119-t1x9gknd 10169 8 Macopharma Macopharma NNP cord-010119-t1x9gknd 10169 9 ) ) -RRB- cord-010119-t1x9gknd 10169 10 is be VBZ cord-010119-t1x9gknd 10169 11 a a DT cord-010119-t1x9gknd 10169 12 UVC UVC NNP cord-010119-t1x9gknd 10169 13 - - HYPH cord-010119-t1x9gknd 10169 14 based base VBN cord-010119-t1x9gknd 10169 15 pathogen pathogen NN cord-010119-t1x9gknd 10169 16 inactivation inactivation NN cord-010119-t1x9gknd 10169 17 system system NN cord-010119-t1x9gknd 10169 18 for for IN cord-010119-t1x9gknd 10169 19 platelet platelet NN cord-010119-t1x9gknd 10169 20 concentrates concentrate NNS cord-010119-t1x9gknd 10169 21 ( ( -LRB- cord-010119-t1x9gknd 10169 22 PCs pc NNS cord-010119-t1x9gknd 10169 23 ) ) -RRB- cord-010119-t1x9gknd 10169 24 . . . cord-010119-t1x9gknd 10170 1 Inactivation inactivation NN cord-010119-t1x9gknd 10170 2 efficiency efficiency NN cord-010119-t1x9gknd 10170 3 has have VBZ cord-010119-t1x9gknd 10170 4 been be VBN cord-010119-t1x9gknd 10170 5 shown show VBN cord-010119-t1x9gknd 10170 6 for for IN cord-010119-t1x9gknd 10170 7 a a DT cord-010119-t1x9gknd 10170 8 broad broad JJ cord-010119-t1x9gknd 10170 9 range range NN cord-010119-t1x9gknd 10170 10 of of IN cord-010119-t1x9gknd 10170 11 viruses virus NNS cord-010119-t1x9gknd 10170 12 , , , cord-010119-t1x9gknd 10170 13 bacteria bacteria NNS cord-010119-t1x9gknd 10170 14 , , , cord-010119-t1x9gknd 10170 15 and and CC cord-010119-t1x9gknd 10170 16 protozoans protozoan NNS cord-010119-t1x9gknd 10170 17 . . . cord-010119-t1x9gknd 10171 1 Previous previous JJ cord-010119-t1x9gknd 10171 2 studies study NNS cord-010119-t1x9gknd 10171 3 with with IN cord-010119-t1x9gknd 10171 4 the the DT cord-010119-t1x9gknd 10171 5 first first JJ cord-010119-t1x9gknd 10171 6 set set NN cord-010119-t1x9gknd 10171 7 of of IN cord-010119-t1x9gknd 10171 8 bacteria bacteria NNS cord-010119-t1x9gknd 10171 9 species specie NNS cord-010119-t1x9gknd 10171 10 of of IN cord-010119-t1x9gknd 10171 11 the the DT cord-010119-t1x9gknd 10171 12 WHO WHO NNP cord-010119-t1x9gknd 10171 13 International International NNP cord-010119-t1x9gknd 10171 14 Repository Repository NNP cord-010119-t1x9gknd 10171 15 of of IN cord-010119-t1x9gknd 10171 16 Platelet Platelet NNP cord-010119-t1x9gknd 10171 17 Transfusion Transfusion NNP cord-010119-t1x9gknd 10171 18 Relevant relevant JJ cord-010119-t1x9gknd 10171 19 Bacterial Bacterial NNP cord-010119-t1x9gknd 10171 20 Reference Reference NNP cord-010119-t1x9gknd 10171 21 Strains Strains NNP cord-010119-t1x9gknd 10171 22 revealed reveal VBD cord-010119-t1x9gknd 10171 23 a a DT cord-010119-t1x9gknd 10171 24 high high JJ cord-010119-t1x9gknd 10171 25 inactivation inactivation NN cord-010119-t1x9gknd 10171 26 capacity capacity NN cord-010119-t1x9gknd 10171 27 for for IN cord-010119-t1x9gknd 10171 28 clinically clinically RB cord-010119-t1x9gknd 10171 29 relevant relevant JJ cord-010119-t1x9gknd 10171 30 bacteria bacteria NNS cord-010119-t1x9gknd 10171 31 . . . cord-010119-t1x9gknd 10172 1 Aim aim VB cord-010119-t1x9gknd 10172 2 of of IN cord-010119-t1x9gknd 10172 3 the the DT cord-010119-t1x9gknd 10172 4 current current JJ cord-010119-t1x9gknd 10172 5 study study NN cord-010119-t1x9gknd 10172 6 was be VBD cord-010119-t1x9gknd 10172 7 to to TO cord-010119-t1x9gknd 10172 8 investigate investigate VB cord-010119-t1x9gknd 10172 9 the the DT cord-010119-t1x9gknd 10172 10 bacteria bacteria NNS cord-010119-t1x9gknd 10172 11 inactivation inactivation NN cord-010119-t1x9gknd 10172 12 efficacy efficacy NN cord-010119-t1x9gknd 10172 13 of of IN cord-010119-t1x9gknd 10172 14 the the DT cord-010119-t1x9gknd 10172 15 THERAFLEX THERAFLEX NNP cord-010119-t1x9gknd 10172 16 UV uv NN cord-010119-t1x9gknd 10172 17 - - HYPH cord-010119-t1x9gknd 10172 18 Platelets platelet NNS cord-010119-t1x9gknd 10172 19 system system NN cord-010119-t1x9gknd 10172 20 for for IN cord-010119-t1x9gknd 10172 21 Enterobacter Enterobacter NNP cord-010119-t1x9gknd 10172 22 cloacae cloacae NN cord-010119-t1x9gknd 10172 23 , , , cord-010119-t1x9gknd 10172 24 Pseudomonas Pseudomonas NNP cord-010119-t1x9gknd 10172 25 fluorescens fluorescen NNS cord-010119-t1x9gknd 10172 26 , , , cord-010119-t1x9gknd 10172 27 Staphylococcus Staphylococcus NNP cord-010119-t1x9gknd 10172 28 aureus aureus NN cord-010119-t1x9gknd 10172 29 and and CC cord-010119-t1x9gknd 10172 30 Streptococcus streptococcus NN cord-010119-t1x9gknd 10172 31 bovis bovi NNS cord-010119-t1x9gknd 10172 32 which which WDT cord-010119-t1x9gknd 10172 33 have have VBP cord-010119-t1x9gknd 10172 34 recently recently RB cord-010119-t1x9gknd 10172 35 been be VBN cord-010119-t1x9gknd 10172 36 added add VBN cord-010119-t1x9gknd 10172 37 to to IN cord-010119-t1x9gknd 10172 38 the the DT cord-010119-t1x9gknd 10172 39 WHO WHO NNP cord-010119-t1x9gknd 10172 40 International International NNP cord-010119-t1x9gknd 10172 41 Repository Repository NNP cord-010119-t1x9gknd 10172 42 . . . cord-010119-t1x9gknd 10173 1 Study Study NNP cord-010119-t1x9gknd 10173 2 Design Design NNP cord-010119-t1x9gknd 10173 3 / / SYM cord-010119-t1x9gknd 10173 4 Method method NN cord-010119-t1x9gknd 10173 5 : : : cord-010119-t1x9gknd 10174 1 PCs pc NNS cord-010119-t1x9gknd 10174 2 were be VBD cord-010119-t1x9gknd 10174 3 produced produce VBN cord-010119-t1x9gknd 10174 4 from from IN cord-010119-t1x9gknd 10174 5 5 5 CD cord-010119-t1x9gknd 10174 6 buffy buffy NNP cord-010119-t1x9gknd 10174 7 coats coat NNS cord-010119-t1x9gknd 10174 8 using use VBG cord-010119-t1x9gknd 10174 9 the the DT cord-010119-t1x9gknd 10174 10 additive additive NN cord-010119-t1x9gknd 10174 11 solution solution NN cord-010119-t1x9gknd 10174 12 SSP1 SSP1 NNP cord-010119-t1x9gknd 10174 13 ( ( -LRB- cord-010119-t1x9gknd 10174 14 MacoPharma MacoPharma NNP cord-010119-t1x9gknd 10174 15 ) ) -RRB- cord-010119-t1x9gknd 10174 16 with with IN cord-010119-t1x9gknd 10174 17 a a DT cord-010119-t1x9gknd 10174 18 residual residual JJ cord-010119-t1x9gknd 10174 19 plasma plasma NN cord-010119-t1x9gknd 10174 20 content content NN cord-010119-t1x9gknd 10174 21 of of IN cord-010119-t1x9gknd 10174 22 35 35 CD cord-010119-t1x9gknd 10174 23 % % NN cord-010119-t1x9gknd 10174 24 . . . cord-010119-t1x9gknd 10175 1 For for IN cord-010119-t1x9gknd 10175 2 inactivation inactivation NN cord-010119-t1x9gknd 10175 3 kinetics kinetic NNS cord-010119-t1x9gknd 10175 4 , , , cord-010119-t1x9gknd 10175 5 PCs pc NNS cord-010119-t1x9gknd 10175 6 ( ( -LRB- cord-010119-t1x9gknd 10175 7 n53 n53 NN cord-010119-t1x9gknd 10175 8 ) ) -RRB- cord-010119-t1x9gknd 10175 9 were be VBD cord-010119-t1x9gknd 10175 10 spiked spike VBN cord-010119-t1x9gknd 10175 11 with with IN cord-010119-t1x9gknd 10175 12 bacteria bacteria NNS cord-010119-t1x9gknd 10175 13 to to IN cord-010119-t1x9gknd 10175 14 a a DT cord-010119-t1x9gknd 10175 15 final final JJ cord-010119-t1x9gknd 10175 16 concentration concentration NN cord-010119-t1x9gknd 10175 17 of of IN cord-010119-t1x9gknd 10175 18 approx.10 approx.10 NNP cord-010119-t1x9gknd 10175 19 6 6 CD cord-010119-t1x9gknd 10175 20 colony colony NN cord-010119-t1x9gknd 10175 21 forming form VBG cord-010119-t1x9gknd 10175 22 units unit NNS cord-010119-t1x9gknd 10175 23 ( ( -LRB- cord-010119-t1x9gknd 10175 24 CFU)/mL CFU)/mL NNS cord-010119-t1x9gknd 10175 25 and and CC cord-010119-t1x9gknd 10175 26 irradiated irradiate VBN cord-010119-t1x9gknd 10175 27 with with IN cord-010119-t1x9gknd 10175 28 increasing increase VBG cord-010119-t1x9gknd 10175 29 doses dose NNS cord-010119-t1x9gknd 10175 30 until until IN cord-010119-t1x9gknd 10175 31 the the DT cord-010119-t1x9gknd 10175 32 full full JJ cord-010119-t1x9gknd 10175 33 UVC UVC NNP cord-010119-t1x9gknd 10175 34 dose dose NN cord-010119-t1x9gknd 10175 35 was be VBD cord-010119-t1x9gknd 10175 36 achieved achieve VBN cord-010119-t1x9gknd 10175 37 . . . cord-010119-t1x9gknd 10176 1 Samples sample NNS cord-010119-t1x9gknd 10176 2 were be VBD cord-010119-t1x9gknd 10176 3 taken take VBN cord-010119-t1x9gknd 10176 4 for for IN cord-010119-t1x9gknd 10176 5 the the DT cord-010119-t1x9gknd 10176 6 bacterial bacterial JJ cord-010119-t1x9gknd 10176 7 titer titer NN cord-010119-t1x9gknd 10176 8 determination determination NN cord-010119-t1x9gknd 10176 9 after after IN cord-010119-t1x9gknd 10176 10 each each DT cord-010119-t1x9gknd 10176 11 irradiation irradiation NN cord-010119-t1x9gknd 10176 12 step step NN cord-010119-t1x9gknd 10176 13 . . . cord-010119-t1x9gknd 10177 1 For for IN cord-010119-t1x9gknd 10177 2 sterilization sterilization NN cord-010119-t1x9gknd 10177 3 studies study NNS cord-010119-t1x9gknd 10177 4 , , , cord-010119-t1x9gknd 10177 5 two two CD cord-010119-t1x9gknd 10177 6 PCs pc NNS cord-010119-t1x9gknd 10177 7 were be VBD cord-010119-t1x9gknd 10177 8 pooled pool VBN cord-010119-t1x9gknd 10177 9 and and CC cord-010119-t1x9gknd 10177 10 inoculated inoculate VBN cord-010119-t1x9gknd 10177 11 with with IN cord-010119-t1x9gknd 10177 12 bacteria bacteria NNS cord-010119-t1x9gknd 10177 13 to to IN cord-010119-t1x9gknd 10177 14 a a DT cord-010119-t1x9gknd 10177 15 final final JJ cord-010119-t1x9gknd 10177 16 concentration concentration NN cord-010119-t1x9gknd 10177 17 of of IN cord-010119-t1x9gknd 10177 18 approximately approximately RB cord-010119-t1x9gknd 10177 19 0.3 0.3 CD cord-010119-t1x9gknd 10177 20 CFU CFU NNP cord-010119-t1x9gknd 10177 21 / / SYM cord-010119-t1x9gknd 10177 22 mL. mL. NNS cord-010119-t1x9gknd 10177 23 Bacteria Bacteria NNS cord-010119-t1x9gknd 10177 24 were be VBD cord-010119-t1x9gknd 10177 25 allowed allow VBN cord-010119-t1x9gknd 10177 26 to to TO cord-010119-t1x9gknd 10177 27 grow grow VB cord-010119-t1x9gknd 10177 28 for for IN cord-010119-t1x9gknd 10177 29 6 6 CD cord-010119-t1x9gknd 10177 30 h h NN cord-010119-t1x9gknd 10177 31 in in IN cord-010119-t1x9gknd 10177 32 the the DT cord-010119-t1x9gknd 10177 33 PCs pc NNS cord-010119-t1x9gknd 10177 34 at at IN cord-010119-t1x9gknd 10177 35 22 22 CD cord-010119-t1x9gknd 10177 36 6 6 CD cord-010119-t1x9gknd 10177 37 28C 28c CD cord-010119-t1x9gknd 10177 38 under under IN cord-010119-t1x9gknd 10177 39 agitation agitation NN cord-010119-t1x9gknd 10177 40 . . . cord-010119-t1x9gknd 10178 1 After after IN cord-010119-t1x9gknd 10178 2 splitting splitting NN cord-010119-t1x9gknd 10178 3 , , , cord-010119-t1x9gknd 10178 4 one one CD cord-010119-t1x9gknd 10178 5 PC pc NN cord-010119-t1x9gknd 10178 6 remained remain VBD cord-010119-t1x9gknd 10178 7 untreated untreated JJ cord-010119-t1x9gknd 10178 8 ( ( -LRB- cord-010119-t1x9gknd 10178 9 growth growth NN cord-010119-t1x9gknd 10178 10 control control NN cord-010119-t1x9gknd 10178 11 ) ) -RRB- cord-010119-t1x9gknd 10178 12 while while IN cord-010119-t1x9gknd 10178 13 the the DT cord-010119-t1x9gknd 10178 14 other other JJ cord-010119-t1x9gknd 10178 15 one one NN cord-010119-t1x9gknd 10178 16 was be VBD cord-010119-t1x9gknd 10178 17 UVC UVC NNP cord-010119-t1x9gknd 10178 18 - - HYPH cord-010119-t1x9gknd 10178 19 treated treat VBN cord-010119-t1x9gknd 10178 20 . . . cord-010119-t1x9gknd 10179 1 After after IN cord-010119-t1x9gknd 10179 2 storage storage NN cord-010119-t1x9gknd 10179 3 for for IN cord-010119-t1x9gknd 10179 4 seven seven CD cord-010119-t1x9gknd 10179 5 days day NNS cord-010119-t1x9gknd 10179 6 , , , cord-010119-t1x9gknd 10179 7 samples sample NNS cord-010119-t1x9gknd 10179 8 were be VBD cord-010119-t1x9gknd 10179 9 taken take VBN cord-010119-t1x9gknd 10179 10 from from IN cord-010119-t1x9gknd 10179 11 both both DT cord-010119-t1x9gknd 10179 12 bags bag NNS cord-010119-t1x9gknd 10179 13 for for IN cord-010119-t1x9gknd 10179 14 sterility sterility NN cord-010119-t1x9gknd 10179 15 testing testing NN cord-010119-t1x9gknd 10179 16 by by IN cord-010119-t1x9gknd 10179 17 BacTALERT bactalert NN cord-010119-t1x9gknd 10179 18 ( ( -LRB- cord-010119-t1x9gknd 10179 19 Biomerieux Biomerieux NNP cord-010119-t1x9gknd 10179 20 ) ) -RRB- cord-010119-t1x9gknd 10179 21 and and CC cord-010119-t1x9gknd 10179 22 for for IN cord-010119-t1x9gknd 10179 23 determination determination NN cord-010119-t1x9gknd 10179 24 of of IN cord-010119-t1x9gknd 10179 25 the the DT cord-010119-t1x9gknd 10179 26 bacterial bacterial JJ cord-010119-t1x9gknd 10179 27 titer titer NN cord-010119-t1x9gknd 10179 28 in in IN cord-010119-t1x9gknd 10179 29 the the DT cord-010119-t1x9gknd 10179 30 untreated untreated JJ cord-010119-t1x9gknd 10179 31 control control NN cord-010119-t1x9gknd 10179 32 units unit NNS cord-010119-t1x9gknd 10179 33 . . . cord-010119-t1x9gknd 10180 1 Results/ Results/ . cord-010119-t1x9gknd 10181 1 Finding find VBG cord-010119-t1x9gknd 10182 1 : : : cord-010119-t1x9gknd 10182 2 Bacteria Bacteria NNS cord-010119-t1x9gknd 10182 3 in in IN cord-010119-t1x9gknd 10182 4 PCs pc NNS cord-010119-t1x9gknd 10182 5 were be VBD cord-010119-t1x9gknd 10182 6 inactivated inactivate VBN cord-010119-t1x9gknd 10182 7 in in IN cord-010119-t1x9gknd 10182 8 a a DT cord-010119-t1x9gknd 10182 9 dose dose NN cord-010119-t1x9gknd 10182 10 - - HYPH cord-010119-t1x9gknd 10182 11 dependent dependent JJ cord-010119-t1x9gknd 10182 12 manner manner NN cord-010119-t1x9gknd 10182 13 by by IN cord-010119-t1x9gknd 10182 14 treatment treatment NN cord-010119-t1x9gknd 10182 15 using use VBG cord-010119-t1x9gknd 10182 16 the the DT cord-010119-t1x9gknd 10182 17 THERAFLEX THERAFLEX NNP cord-010119-t1x9gknd 10182 18 UV uv NN cord-010119-t1x9gknd 10182 19 - - HYPH cord-010119-t1x9gknd 10182 20 Platelets platelet NNS cord-010119-t1x9gknd 10182 21 system system NN cord-010119-t1x9gknd 10182 22 . . . cord-010119-t1x9gknd 10183 1 Mean mean JJ cord-010119-t1x9gknd 10183 2 log log VB cord-010119-t1x9gknd 10183 3 10 10 CD cord-010119-t1x9gknd 10183 4 reduction reduction NN cord-010119-t1x9gknd 10183 5 factors factor NNS cord-010119-t1x9gknd 10183 6 ranged range VBD cord-010119-t1x9gknd 10183 7 from from IN cord-010119-t1x9gknd 10183 8 6 6 CD cord-010119-t1x9gknd 10183 9 to to IN cord-010119-t1x9gknd 10183 10 7 7 CD cord-010119-t1x9gknd 10183 11 for for IN cord-010119-t1x9gknd 10183 12 Enterobacter Enterobacter NNP cord-010119-t1x9gknd 10183 13 cloacae cloacae NN cord-010119-t1x9gknd 10183 14 ( ( -LRB- cord-010119-t1x9gknd 10183 15 6.3 6.3 CD cord-010119-t1x9gknd 10183 16 6 6 CD cord-010119-t1x9gknd 10183 17 0.6 0.6 CD cord-010119-t1x9gknd 10183 18 , , , cord-010119-t1x9gknd 10183 19 PEI PEI NNP cord-010119-t1x9gknd 10183 20 - - HYPH cord-010119-t1x9gknd 10183 21 B B NNP cord-010119-t1x9gknd 10183 22 - - HYPH cord-010119-t1x9gknd 10183 23 P-43 P-43 NNP cord-010119-t1x9gknd 10183 24 ) ) -RRB- cord-010119-t1x9gknd 10183 25 , , , cord-010119-t1x9gknd 10183 26 Pseudomonas Pseudomonas NNP cord-010119-t1x9gknd 10183 27 fluorescens fluorescen NNS cord-010119-t1x9gknd 10183 28 ( ( -LRB- cord-010119-t1x9gknd 10183 29 7.1 7.1 CD cord-010119-t1x9gknd 10183 30 6 6 CD cord-010119-t1x9gknd 10183 31 0.4 0.4 CD cord-010119-t1x9gknd 10183 32 , , , cord-010119-t1x9gknd 10183 33 PEI PEI NNP cord-010119-t1x9gknd 10183 34 - - HYPH cord-010119-t1x9gknd 10183 35 B B NNP cord-010119-t1x9gknd 10183 36 - - HYPH cord-010119-t1x9gknd 10183 37 P-77 P-77 NNP cord-010119-t1x9gknd 10183 38 ) ) -RRB- cord-010119-t1x9gknd 10183 39 , , , cord-010119-t1x9gknd 10183 40 Staphylococcus Staphylococcus NNP cord-010119-t1x9gknd 10183 41 aureus aureus NN cord-010119-t1x9gknd 10183 42 ( ( -LRB- cord-010119-t1x9gknd 10183 43 6.6 6.6 CD cord-010119-t1x9gknd 10183 44 6 6 CD cord-010119-t1x9gknd 10183 45 0.4 0.4 CD cord-010119-t1x9gknd 10183 46 , , , cord-010119-t1x9gknd 10183 47 PEI PEI NNP cord-010119-t1x9gknd 10183 48 - - HYPH cord-010119-t1x9gknd 10183 49 B B NNP cord-010119-t1x9gknd 10183 50 - - HYPH cord-010119-t1x9gknd 10183 51 P-63 P-63 NNP cord-010119-t1x9gknd 10183 52 ) ) -RRB- cord-010119-t1x9gknd 10183 53 , , , cord-010119-t1x9gknd 10183 54 and and CC cord-010119-t1x9gknd 10183 55 Streptococcus Streptococcus NNP cord-010119-t1x9gknd 10183 56 bovis bovi NNS cord-010119-t1x9gknd 10183 57 ( ( -LRB- cord-010119-t1x9gknd 10183 58 7.0 7.0 CD cord-010119-t1x9gknd 10183 59 6 6 CD cord-010119-t1x9gknd 10183 60 0.3 0.3 CD cord-010119-t1x9gknd 10183 61 , , , cord-010119-t1x9gknd 10183 62 PEI PEI NNP cord-010119-t1x9gknd 10183 63 - - HYPH cord-010119-t1x9gknd 10183 64 B B NNP cord-010119-t1x9gknd 10183 65 - - HYPH cord-010119-t1x9gknd 10183 66 P-61 P-61 NNP cord-010119-t1x9gknd 10183 67 ) ) -RRB- cord-010119-t1x9gknd 10183 68 . . . cord-010119-t1x9gknd 10184 1 PCs pc NNS cord-010119-t1x9gknd 10184 2 ( ( -LRB- cord-010119-t1x9gknd 10184 3 n512 n512 NNP cord-010119-t1x9gknd 10184 4 for for IN cord-010119-t1x9gknd 10184 5 each each DT cord-010119-t1x9gknd 10184 6 species specie NNS cord-010119-t1x9gknd 10184 7 ) ) -RRB- cord-010119-t1x9gknd 10184 8 spiked spike VBD cord-010119-t1x9gknd 10184 9 with with IN cord-010119-t1x9gknd 10184 10 these these DT cord-010119-t1x9gknd 10184 11 different different JJ cord-010119-t1x9gknd 10184 12 bacteria bacteria NNS cord-010119-t1x9gknd 10184 13 species specie NNS cord-010119-t1x9gknd 10184 14 were be VBD cord-010119-t1x9gknd 10184 15 efficiently efficiently RB cord-010119-t1x9gknd 10184 16 sterilized sterilize VBN cord-010119-t1x9gknd 10184 17 ( ( -LRB- cord-010119-t1x9gknd 10184 18 12 12 CD cord-010119-t1x9gknd 10184 19 out out IN cord-010119-t1x9gknd 10184 20 of of IN cord-010119-t1x9gknd 10184 21 12 12 CD cord-010119-t1x9gknd 10184 22 ) ) -RRB- cord-010119-t1x9gknd 10184 23 . . . cord-010119-t1x9gknd 10185 1 Treated treated JJ cord-010119-t1x9gknd 10185 2 PCs pc NNS cord-010119-t1x9gknd 10185 3 remained remain VBD cord-010119-t1x9gknd 10185 4 sterile sterile JJ cord-010119-t1x9gknd 10185 5 during during IN cord-010119-t1x9gknd 10185 6 storage storage NN cord-010119-t1x9gknd 10185 7 for for IN cord-010119-t1x9gknd 10185 8 7 7 CD cord-010119-t1x9gknd 10185 9 days day NNS cord-010119-t1x9gknd 10185 10 , , , cord-010119-t1x9gknd 10185 11 while while IN cord-010119-t1x9gknd 10185 12 bacteria bacteria NNS cord-010119-t1x9gknd 10185 13 in in IN cord-010119-t1x9gknd 10185 14 non non JJ cord-010119-t1x9gknd 10185 15 - - JJ cord-010119-t1x9gknd 10185 16 treated treat VBN cord-010119-t1x9gknd 10185 17 PCs pc NNS cord-010119-t1x9gknd 10185 18 grew grow VBD cord-010119-t1x9gknd 10185 19 to to IN cord-010119-t1x9gknd 10185 20 high high JJ cord-010119-t1x9gknd 10185 21 titers titer NNS cord-010119-t1x9gknd 10185 22 of of IN cord-010119-t1x9gknd 10185 23 10 10 CD cord-010119-t1x9gknd 10185 24 6 6 CD cord-010119-t1x9gknd 10185 25 -10 -10 CD cord-010119-t1x9gknd 10185 26 8 8 CD cord-010119-t1x9gknd 10185 27 CFU CFU NNP cord-010119-t1x9gknd 10185 28 / / SYM cord-010119-t1x9gknd 10185 29 mL. mL. NNP cord-010119-t1x9gknd 10185 30 The the DT cord-010119-t1x9gknd 10185 31 THERAFLEX THERAFLEX NNP cord-010119-t1x9gknd 10185 32 UV uv NN cord-010119-t1x9gknd 10185 33 - - HYPH cord-010119-t1x9gknd 10185 34 Platelets platelet NNS cord-010119-t1x9gknd 10185 35 system system NN cord-010119-t1x9gknd 10185 36 efficiently efficiently RB cord-010119-t1x9gknd 10185 37 inactivates inactivate VBZ cord-010119-t1x9gknd 10185 38 a a DT cord-010119-t1x9gknd 10185 39 broad broad JJ cord-010119-t1x9gknd 10185 40 range range NN cord-010119-t1x9gknd 10185 41 of of IN cord-010119-t1x9gknd 10185 42 different different JJ cord-010119-t1x9gknd 10185 43 bacteria bacteria NNS cord-010119-t1x9gknd 10185 44 species specie NNS cord-010119-t1x9gknd 10185 45 , , , cord-010119-t1x9gknd 10185 46 including include VBG cord-010119-t1x9gknd 10185 47 the the DT cord-010119-t1x9gknd 10185 48 WHO WHO NNP cord-010119-t1x9gknd 10185 49 reference reference NN cord-010119-t1x9gknd 10185 50 strains strain NNS cord-010119-t1x9gknd 10185 51 . . . cord-010119-t1x9gknd 10186 1 Sterility sterility NN cord-010119-t1x9gknd 10186 2 is be VBZ cord-010119-t1x9gknd 10186 3 maintained maintain VBN cord-010119-t1x9gknd 10186 4 over over IN cord-010119-t1x9gknd 10186 5 a a DT cord-010119-t1x9gknd 10186 6 storage storage NN cord-010119-t1x9gknd 10186 7 period period NN cord-010119-t1x9gknd 10186 8 of of IN cord-010119-t1x9gknd 10186 9 7 7 CD cord-010119-t1x9gknd 10186 10 days day NNS cord-010119-t1x9gknd 10186 11 . . . cord-010119-t1x9gknd 10187 1 These these DT cord-010119-t1x9gknd 10187 2 results result NNS cord-010119-t1x9gknd 10187 3 suggest suggest VBP cord-010119-t1x9gknd 10187 4 that that IN cord-010119-t1x9gknd 10187 5 the the DT cord-010119-t1x9gknd 10187 6 UVC UVC NNP cord-010119-t1x9gknd 10187 7 - - HYPH cord-010119-t1x9gknd 10187 8 based base VBN cord-010119-t1x9gknd 10187 9 pathogen pathogen NN cord-010119-t1x9gknd 10187 10 inactivation inactivation NN cord-010119-t1x9gknd 10187 11 technology technology NN cord-010119-t1x9gknd 10187 12 will will MD cord-010119-t1x9gknd 10187 13 significantly significantly RB cord-010119-t1x9gknd 10187 14 improve improve VB cord-010119-t1x9gknd 10187 15 the the DT cord-010119-t1x9gknd 10187 16 bacterial bacterial JJ cord-010119-t1x9gknd 10187 17 safety safety NN cord-010119-t1x9gknd 10187 18 of of IN cord-010119-t1x9gknd 10187 19 platelet platelet NN cord-010119-t1x9gknd 10187 20 transfusions transfusion NNS cord-010119-t1x9gknd 10187 21 . . . cord-010119-t1x9gknd 10188 1 Transfusion transfusion NN cord-010119-t1x9gknd 10188 2 Transmissible transmissible JJ cord-010119-t1x9gknd 10188 3 Infections Infections NNPS cord-010119-t1x9gknd 10188 4 Among among IN cord-010119-t1x9gknd 10188 5 Blood blood NN cord-010119-t1x9gknd 10188 6 Donors Donors NNPS cord-010119-t1x9gknd 10188 7 and and CC cord-010119-t1x9gknd 10188 8 Strategy Strategy NNP cord-010119-t1x9gknd 10188 9 on on IN cord-010119-t1x9gknd 10188 10 Direct Direct NNP cord-010119-t1x9gknd 10188 11 Laboratory Laboratory NNP cord-010119-t1x9gknd 10188 12 Testing Testing NNP cord-010119-t1x9gknd 10188 13 Cost cost NN cord-010119-t1x9gknd 10188 14 of of IN cord-010119-t1x9gknd 10188 15 Blood blood NN cord-010119-t1x9gknd 10188 16 Screening screening NN cord-010119-t1x9gknd 10188 17 at at IN cord-010119-t1x9gknd 10188 18 National National NNP cord-010119-t1x9gknd 10188 19 Blood Blood NNP cord-010119-t1x9gknd 10188 20 Bank Bank NNP cord-010119-t1x9gknd 10188 21 Center Center NNP cord-010119-t1x9gknd 10188 22 , , , cord-010119-t1x9gknd 10188 23 Addis Addis NNP cord-010119-t1x9gknd 10188 24 Ababa Ababa NNP cord-010119-t1x9gknd 10188 25 , , , cord-010119-t1x9gknd 10188 26 Ethiopia Ethiopia NNP cord-010119-t1x9gknd 10188 27 Abraham Abraham NNP cord-010119-t1x9gknd 10188 28 Zewoldie Zewoldie NNP cord-010119-t1x9gknd 10189 1 * * NFP cord-010119-t1x9gknd 10189 2 . . . cord-010119-t1x9gknd 10190 1 National National NNP cord-010119-t1x9gknd 10190 2 Blood Blood NNP cord-010119-t1x9gknd 10190 3 Bank Bank NNP cord-010119-t1x9gknd 10190 4 Service Service NNP cord-010119-t1x9gknd 10190 5 Background Background NNP cord-010119-t1x9gknd 10190 6 / / SYM cord-010119-t1x9gknd 10190 7 Case Case NNP cord-010119-t1x9gknd 10190 8 Studies Studies NNPS cord-010119-t1x9gknd 10190 9 : : : cord-010119-t1x9gknd 10190 10 blood blood NN cord-010119-t1x9gknd 10190 11 and and CC cord-010119-t1x9gknd 10190 12 its -PRON- PRP$ cord-010119-t1x9gknd 10190 13 components component NNS cord-010119-t1x9gknd 10190 14 are be VBP cord-010119-t1x9gknd 10190 15 life life NN cord-010119-t1x9gknd 10190 16 saving saving NN cord-010119-t1x9gknd 10190 17 ; ; : cord-010119-t1x9gknd 10190 18 however however RB cord-010119-t1x9gknd 10190 19 , , , cord-010119-t1x9gknd 10190 20 they -PRON- PRP cord-010119-t1x9gknd 10190 21 are be VBP cord-010119-t1x9gknd 10190 22 also also RB cord-010119-t1x9gknd 10190 23 associated associate VBN cord-010119-t1x9gknd 10190 24 with with IN cord-010119-t1x9gknd 10190 25 life life NN cord-010119-t1x9gknd 10190 26 threatening threaten VBG cord-010119-t1x9gknd 10190 27 hazards hazard NNS cord-010119-t1x9gknd 10190 28 such such JJ cord-010119-t1x9gknd 10190 29 as as IN cord-010119-t1x9gknd 10190 30 transfusion transfusion NN cord-010119-t1x9gknd 10190 31 transmitted transmit VBN cord-010119-t1x9gknd 10190 32 infections infection NNS cord-010119-t1x9gknd 10190 33 ( ( -LRB- cord-010119-t1x9gknd 10190 34 TTIs tti NNS cord-010119-t1x9gknd 10190 35 ) ) -RRB- cord-010119-t1x9gknd 10190 36 . . . cord-010119-t1x9gknd 10191 1 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 10191 2 B B NNP cord-010119-t1x9gknd 10191 3 virus virus NN cord-010119-t1x9gknd 10191 4 ( ( -LRB- cord-010119-t1x9gknd 10191 5 HBV HBV NNP cord-010119-t1x9gknd 10191 6 ) ) -RRB- cord-010119-t1x9gknd 10191 7 , , , cord-010119-t1x9gknd 10191 8 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 10191 9 C C NNP cord-010119-t1x9gknd 10191 10 virus virus NN cord-010119-t1x9gknd 10191 11 ( ( -LRB- cord-010119-t1x9gknd 10191 12 HCV HCV NNP cord-010119-t1x9gknd 10191 13 ) ) -RRB- cord-010119-t1x9gknd 10191 14 , , , cord-010119-t1x9gknd 10191 15 human human JJ cord-010119-t1x9gknd 10191 16 immunodeficiency immunodeficiency NN cord-010119-t1x9gknd 10191 17 virus virus NN cord-010119-t1x9gknd 10191 18 ( ( -LRB- cord-010119-t1x9gknd 10191 19 HIV HIV NNP cord-010119-t1x9gknd 10191 20 ) ) -RRB- cord-010119-t1x9gknd 10191 21 and and CC cord-010119-t1x9gknd 10191 22 syphilis syphili NNS cord-010119-t1x9gknd 10191 23 are be VBP cord-010119-t1x9gknd 10191 24 the the DT cord-010119-t1x9gknd 10191 25 most most RBS cord-010119-t1x9gknd 10191 26 serious serious JJ cord-010119-t1x9gknd 10191 27 infections infection NNS cord-010119-t1x9gknd 10191 28 transmitted transmit VBN cord-010119-t1x9gknd 10191 29 during during IN cord-010119-t1x9gknd 10191 30 blood blood NN cord-010119-t1x9gknd 10191 31 transfusion transfusion NN cord-010119-t1x9gknd 10191 32 . . . cord-010119-t1x9gknd 10192 1 Serious serious JJ cord-010119-t1x9gknd 10192 2 of of IN cord-010119-t1x9gknd 10192 3 blood blood NN cord-010119-t1x9gknd 10192 4 shortages shortage NNS cord-010119-t1x9gknd 10192 5 especially especially RB cord-010119-t1x9gknd 10192 6 in in IN cord-010119-t1x9gknd 10192 7 developing develop VBG cord-010119-t1x9gknd 10192 8 countries country NNS cord-010119-t1x9gknd 10192 9 and and CC cord-010119-t1x9gknd 10192 10 reliance reliance NN cord-010119-t1x9gknd 10192 11 on on IN cord-010119-t1x9gknd 10192 12 unsafe unsafe JJ cord-010119-t1x9gknd 10192 13 family family NN cord-010119-t1x9gknd 10192 14 replacement replacement NN cord-010119-t1x9gknd 10192 15 or or CC cord-010119-t1x9gknd 10192 16 paid pay VBD cord-010119-t1x9gknd 10192 17 donors donor NNS cord-010119-t1x9gknd 10192 18 also also RB cord-010119-t1x9gknd 10192 19 contribute contribute VBP cord-010119-t1x9gknd 10192 20 to to IN cord-010119-t1x9gknd 10192 21 an an DT cord-010119-t1x9gknd 10192 22 increased increase VBN cord-010119-t1x9gknd 10192 23 risk risk NN cord-010119-t1x9gknd 10192 24 of of IN cord-010119-t1x9gknd 10192 25 TTIs tti NNS cord-010119-t1x9gknd 10192 26 . . . cord-010119-t1x9gknd 10193 1 Knowing know VBG cord-010119-t1x9gknd 10193 2 the the DT cord-010119-t1x9gknd 10193 3 current current JJ cord-010119-t1x9gknd 10193 4 prevalence prevalence NN cord-010119-t1x9gknd 10193 5 of of IN cord-010119-t1x9gknd 10193 6 TTIs tti NNS cord-010119-t1x9gknd 10193 7 among among IN cord-010119-t1x9gknd 10193 8 blood blood NN cord-010119-t1x9gknd 10193 9 donors donor NNS cord-010119-t1x9gknd 10193 10 will will MD cord-010119-t1x9gknd 10193 11 be be VB cord-010119-t1x9gknd 10193 12 crucial crucial JJ cord-010119-t1x9gknd 10193 13 in in IN cord-010119-t1x9gknd 10193 14 donor donor NN cord-010119-t1x9gknd 10193 15 program program NN cord-010119-t1x9gknd 10193 16 strategy strategy NN cord-010119-t1x9gknd 10193 17 development development NN cord-010119-t1x9gknd 10193 18 and and CC cord-010119-t1x9gknd 10193 19 cost cost VBD cord-010119-t1x9gknd 10193 20 effective effective JJ cord-010119-t1x9gknd 10193 21 alternative alternative JJ cord-010119-t1x9gknd 10193 22 strategies strategy NNS cord-010119-t1x9gknd 10193 23 of of IN cord-010119-t1x9gknd 10193 24 blood blood NN cord-010119-t1x9gknd 10193 25 screening screening NN cord-010119-t1x9gknd 10193 26 are be VBP cord-010119-t1x9gknd 10193 27 highly highly RB cord-010119-t1x9gknd 10193 28 required require VBN cord-010119-t1x9gknd 10193 29 especially especially RB cord-010119-t1x9gknd 10193 30 in in IN cord-010119-t1x9gknd 10193 31 resource resource NN cord-010119-t1x9gknd 10193 32 limited limited JJ cord-010119-t1x9gknd 10193 33 setup setup NN cord-010119-t1x9gknd 10193 34 . . . cord-010119-t1x9gknd 10194 1 Study Study NNP cord-010119-t1x9gknd 10194 2 Design Design NNP cord-010119-t1x9gknd 10194 3 / / SYM cord-010119-t1x9gknd 10194 4 Method method NN cord-010119-t1x9gknd 10194 5 : : : cord-010119-t1x9gknd 10195 1 A a DT cord-010119-t1x9gknd 10195 2 retrospective retrospective JJ cord-010119-t1x9gknd 10195 3 analysis analysis NN cord-010119-t1x9gknd 10195 4 of of IN cord-010119-t1x9gknd 10195 5 blood blood NN cord-010119-t1x9gknd 10195 6 donors donor NNS cord-010119-t1x9gknd 10195 7 ' ' POS cord-010119-t1x9gknd 10195 8 record record NN cord-010119-t1x9gknd 10195 9 covering cover VBG cord-010119-t1x9gknd 10195 10 the the DT cord-010119-t1x9gknd 10195 11 period period NN cord-010119-t1x9gknd 10195 12 from from IN cord-010119-t1x9gknd 10195 13 July July NNP cord-010119-t1x9gknd 10195 14 1 1 CD cord-010119-t1x9gknd 10195 15 , , , cord-010119-t1x9gknd 10195 16 2008 2008 CD cord-010119-t1x9gknd 10195 17 to to IN cord-010119-t1x9gknd 10195 18 July July NNP cord-010119-t1x9gknd 10195 19 30 30 CD cord-010119-t1x9gknd 10195 20 , , , cord-010119-t1x9gknd 10195 21 2013 2013 CD cord-010119-t1x9gknd 10195 22 was be VBD cord-010119-t1x9gknd 10195 23 conducted conduct VBN cord-010119-t1x9gknd 10195 24 . . . cord-010119-t1x9gknd 10196 1 The the DT cord-010119-t1x9gknd 10196 2 data datum NNS cord-010119-t1x9gknd 10196 3 was be VBD cord-010119-t1x9gknd 10196 4 collected collect VBN cord-010119-t1x9gknd 10196 5 from from IN cord-010119-t1x9gknd 10196 6 the the DT cord-010119-t1x9gknd 10196 7 Nation Nation NNP cord-010119-t1x9gknd 10196 8 al al NNP cord-010119-t1x9gknd 10196 9 Blood Blood NNP cord-010119-t1x9gknd 10196 10 Bank Bank NNP cord-010119-t1x9gknd 10196 11 ( ( -LRB- cord-010119-t1x9gknd 10196 12 NBB NBB NNP cord-010119-t1x9gknd 10196 13 ) ) -RRB- cord-010119-t1x9gknd 10196 14 center center NNP cord-010119-t1x9gknd 10196 15 Donor Donor NNP cord-010119-t1x9gknd 10196 16 Data Data NNP cord-010119-t1x9gknd 10196 17 base base NN cord-010119-t1x9gknd 10196 18 . . . cord-010119-t1x9gknd 10197 1 In in IN cord-010119-t1x9gknd 10197 2 addition addition NN cord-010119-t1x9gknd 10197 3 , , , cord-010119-t1x9gknd 10197 4 direct direct JJ cord-010119-t1x9gknd 10197 5 laboratory laboratory NN cord-010119-t1x9gknd 10197 6 costs cost NNS cord-010119-t1x9gknd 10197 7 of of IN cord-010119-t1x9gknd 10197 8 parallel parallel JJ cord-010119-t1x9gknd 10197 9 versus versus IN cord-010119-t1x9gknd 10197 10 sequential sequential JJ cord-010119-t1x9gknd 10197 11 strategy strategy NN cord-010119-t1x9gknd 10197 12 of of IN cord-010119-t1x9gknd 10197 13 blood blood NN cord-010119-t1x9gknd 10197 14 screening screening NN cord-010119-t1x9gknd 10197 15 were be VBD cord-010119-t1x9gknd 10197 16 compared compare VBN cord-010119-t1x9gknd 10197 17 using use VBG cord-010119-t1x9gknd 10197 18 the the DT cord-010119-t1x9gknd 10197 19 current current JJ cord-010119-t1x9gknd 10197 20 price price NN cord-010119-t1x9gknd 10197 21 of of IN cord-010119-t1x9gknd 10197 22 the the DT cord-010119-t1x9gknd 10197 23 laboratory laboratory NN cord-010119-t1x9gknd 10197 24 costs cost NNS cord-010119-t1x9gknd 10197 25 . . . cord-010119-t1x9gknd 10198 1 Data datum NNS cord-010119-t1x9gknd 10198 2 was be VBD cord-010119-t1x9gknd 10198 3 first first RB cord-010119-t1x9gknd 10198 4 exported export VBN cord-010119-t1x9gknd 10198 5 to to IN cord-010119-t1x9gknd 10198 6 SPSS SPSS NNP cord-010119-t1x9gknd 10198 7 version version NN cord-010119-t1x9gknd 10198 8 16 16 CD cord-010119-t1x9gknd 10198 9 software software NN cord-010119-t1x9gknd 10198 10 for for IN cord-010119-t1x9gknd 10198 11 analysis analysis NN cord-010119-t1x9gknd 10198 12 . . . cord-010119-t1x9gknd 10199 1 Data data NN cord-010119-t1x9gknd 10199 2 analysis analysis NN cord-010119-t1x9gknd 10199 3 was be VBD cord-010119-t1x9gknd 10199 4 performed perform VBN cord-010119-t1x9gknd 10199 5 using use VBG cord-010119-t1x9gknd 10199 6 scores score NNS cord-010119-t1x9gknd 10199 7 and and CC cord-010119-t1x9gknd 10199 8 odds odd NNS cord-010119-t1x9gknd 10199 9 ratio ratio NN cord-010119-t1x9gknd 10199 10 using use VBG cord-010119-t1x9gknd 10199 11 same same JJ cord-010119-t1x9gknd 10199 12 software software NN cord-010119-t1x9gknd 10199 13 to to TO cord-010119-t1x9gknd 10199 14 look look VB cord-010119-t1x9gknd 10199 15 for for IN cord-010119-t1x9gknd 10199 16 an an DT cord-010119-t1x9gknd 10199 17 association association NN cord-010119-t1x9gknd 10199 18 between between IN cord-010119-t1x9gknd 10199 19 dependent dependent JJ cord-010119-t1x9gknd 10199 20 and and CC cord-010119-t1x9gknd 10199 21 independent independent JJ cord-010119-t1x9gknd 10199 22 variables variable NNS cord-010119-t1x9gknd 10199 23 . . . cord-010119-t1x9gknd 10200 1 P p NN cord-010119-t1x9gknd 10200 2 values value NNS cord-010119-t1x9gknd 10200 3 less less JJR cord-010119-t1x9gknd 10200 4 than than IN cord-010119-t1x9gknd 10200 5 0.05 0.05 CD cord-010119-t1x9gknd 10200 6 were be VBD cord-010119-t1x9gknd 10200 7 considered consider VBN cord-010119-t1x9gknd 10200 8 significant significant JJ cord-010119-t1x9gknd 10200 9 . . . cord-010119-t1x9gknd 10201 1 Results/ Results/ . cord-010119-t1x9gknd 10202 1 Finding finding NN cord-010119-t1x9gknd 10202 2 : : : cord-010119-t1x9gknd 10203 1 A a DT cord-010119-t1x9gknd 10203 2 total total NN cord-010119-t1x9gknd 10203 3 of of IN cord-010119-t1x9gknd 10203 4 173 173 CD cord-010119-t1x9gknd 10203 5 , , , cord-010119-t1x9gknd 10203 6 207 207 CD cord-010119-t1x9gknd 10203 7 consecutive consecutive JJ cord-010119-t1x9gknd 10203 8 blood blood NN cord-010119-t1x9gknd 10203 9 donors donor NNS cord-010119-t1x9gknd 10203 10 were be VBD cord-010119-t1x9gknd 10203 11 screened screen VBN cord-010119-t1x9gknd 10203 12 between between IN cord-010119-t1x9gknd 10203 13 2008 2008 CD cord-010119-t1x9gknd 10203 14 and and CC cord-010119-t1x9gknd 10203 15 2013 2013 CD cord-010119-t1x9gknd 10203 16 . . . cord-010119-t1x9gknd 10204 1 The the DT cord-010119-t1x9gknd 10204 2 overall overall JJ cord-010119-t1x9gknd 10204 3 seroprevalence seroprevalence NN cord-010119-t1x9gknd 10204 4 rate rate NN cord-010119-t1x9gknd 10204 5 of of IN cord-010119-t1x9gknd 10204 6 HBV HBV NNP cord-010119-t1x9gknd 10204 7 , , , cord-010119-t1x9gknd 10204 8 HIV HIV NNP cord-010119-t1x9gknd 10204 9 , , , cord-010119-t1x9gknd 10204 10 HCV HCV NNP cord-010119-t1x9gknd 10204 11 and and CC cord-010119-t1x9gknd 10204 12 syphilis syphili NNS cord-010119-t1x9gknd 10204 13 of of IN cord-010119-t1x9gknd 10204 14 blood blood NN cord-010119-t1x9gknd 10204 15 donors donor NNS cord-010119-t1x9gknd 10204 16 was be VBD cord-010119-t1x9gknd 10204 17 5.0 5.0 CD cord-010119-t1x9gknd 10204 18 % % NN cord-010119-t1x9gknd 10204 19 , , , cord-010119-t1x9gknd 10204 20 1.6 1.6 CD cord-010119-t1x9gknd 10204 21 % % NN cord-010119-t1x9gknd 10204 22 , , , cord-010119-t1x9gknd 10204 23 1.4 1.4 CD cord-010119-t1x9gknd 10204 24 % % NN cord-010119-t1x9gknd 10204 25 and and CC cord-010119-t1x9gknd 10204 26 0.1 0.1 CD cord-010119-t1x9gknd 10204 27 % % NN cord-010119-t1x9gknd 10204 28 respectively respectively RB cord-010119-t1x9gknd 10204 29 . . . cord-010119-t1x9gknd 10205 1 The the DT cord-010119-t1x9gknd 10205 2 HIV HIV NNP cord-010119-t1x9gknd 10205 3 - - HYPH cord-010119-t1x9gknd 10205 4 HBV HBV NNP cord-010119-t1x9gknd 10205 5 co co NN cord-010119-t1x9gknd 10205 6 - - NN cord-010119-t1x9gknd 10205 7 infection infection NN cord-010119-t1x9gknd 10205 8 was be VBD cord-010119-t1x9gknd 10205 9 higher high JJR cord-010119-t1x9gknd 10205 10 among among IN cord-010119-t1x9gknd 10205 11 blood blood NN cord-010119-t1x9gknd 10205 12 donors donor NNS cord-010119-t1x9gknd 10205 13 135(41.79 135(41.79 CD cord-010119-t1x9gknd 10205 14 % % NN cord-010119-t1x9gknd 10205 15 ) ) -RRB- cord-010119-t1x9gknd 10205 16 followed follow VBN cord-010119-t1x9gknd 10205 17 by by IN cord-010119-t1x9gknd 10205 18 HBV HBV NNP cord-010119-t1x9gknd 10205 19 - - HYPH cord-010119-t1x9gknd 10205 20 HCV HCV NNP cord-010119-t1x9gknd 10205 21 co co NN cord-010119-t1x9gknd 10205 22 - - NN cord-010119-t1x9gknd 10205 23 infection infection NN cord-010119-t1x9gknd 10205 24 whish whish NN cord-010119-t1x9gknd 10205 25 accounts account VBZ cord-010119-t1x9gknd 10205 26 about about RB cord-010119-t1x9gknd 10205 27 103(31.89 103(31.89 CD cord-010119-t1x9gknd 10205 28 % % NN cord-010119-t1x9gknd 10205 29 ) ) -RRB- cord-010119-t1x9gknd 10205 30 . . . cord-010119-t1x9gknd 10206 1 Significantly significantly RB cord-010119-t1x9gknd 10206 2 increased increase VBN cord-010119-t1x9gknd 10206 3 sero sero NN cord-010119-t1x9gknd 10206 4 - - HYPH cord-010119-t1x9gknd 10206 5 prevalence prevalence NN cord-010119-t1x9gknd 10206 6 of of IN cord-010119-t1x9gknd 10206 7 TTIs tti NNS cord-010119-t1x9gknd 10206 8 was be VBD cord-010119-t1x9gknd 10206 9 observed observe VBN cord-010119-t1x9gknd 10206 10 in in IN cord-010119-t1x9gknd 10206 11 among among IN cord-010119-t1x9gknd 10206 12 Family Family NNP cord-010119-t1x9gknd 10206 13 replacement replacement NN cord-010119-t1x9gknd 10206 14 donors donor NNS cord-010119-t1x9gknd 10206 15 , , , cord-010119-t1x9gknd 10206 16 factory factory NN cord-010119-t1x9gknd 10206 17 workers worker NNS cord-010119-t1x9gknd 10206 18 , , , cord-010119-t1x9gknd 10206 19 daily daily JJ cord-010119-t1x9gknd 10206 20 labors labor NNS cord-010119-t1x9gknd 10206 21 and and CC cord-010119-t1x9gknd 10206 22 the the DT cord-010119-t1x9gknd 10206 23 age age NN cord-010119-t1x9gknd 10206 24 group group NN cord-010119-t1x9gknd 10206 25 of of IN cord-010119-t1x9gknd 10206 26 26 26 CD cord-010119-t1x9gknd 10206 27 - - SYM cord-010119-t1x9gknd 10206 28 35 35 CD cord-010119-t1x9gknd 10206 29 . . . cord-010119-t1x9gknd 10207 1 In in IN cord-010119-t1x9gknd 10207 2 this this DT cord-010119-t1x9gknd 10207 3 study study NN cord-010119-t1x9gknd 10207 4 the the DT cord-010119-t1x9gknd 10207 5 difference difference NN cord-010119-t1x9gknd 10207 6 in in IN cord-010119-t1x9gknd 10207 7 cost cost NN cord-010119-t1x9gknd 10207 8 between between IN cord-010119-t1x9gknd 10207 9 the the DT cord-010119-t1x9gknd 10207 10 current current NN cord-010119-t1x9gknd 10207 11 in in IN cord-010119-t1x9gknd 10207 12 use use NN cord-010119-t1x9gknd 10207 13 strategy strategy NN cord-010119-t1x9gknd 10207 14 ( ( -LRB- cord-010119-t1x9gknd 10207 15 parallel parallel JJ cord-010119-t1x9gknd 10207 16 ) ) -RRB- cord-010119-t1x9gknd 10207 17 versus versus IN cord-010119-t1x9gknd 10207 18 the the DT cord-010119-t1x9gknd 10207 19 newly newly RB cord-010119-t1x9gknd 10207 20 proposed propose VBN cord-010119-t1x9gknd 10207 21 designed design VBN cord-010119-t1x9gknd 10207 22 sequential sequential JJ cord-010119-t1x9gknd 10207 23 testing testing NN cord-010119-t1x9gknd 10207 24 algorism algorism NN cord-010119-t1x9gknd 10207 25 was be VBD cord-010119-t1x9gknd 10207 26 746,773.9 746,773.9 CD cord-010119-t1x9gknd 10207 27 Ethiopian ethiopian JJ cord-010119-t1x9gknd 10207 28 Birr Birr NNP cord-010119-t1x9gknd 10207 29 . . . cord-010119-t1x9gknd 10208 1 Conclusion conclusion NN cord-010119-t1x9gknd 10208 2 : : : cord-010119-t1x9gknd 10209 1 A a DT cord-010119-t1x9gknd 10209 2 significant significant JJ cord-010119-t1x9gknd 10209 3 percentage percentage NN cord-010119-t1x9gknd 10209 4 of of IN cord-010119-t1x9gknd 10209 5 the the DT cord-010119-t1x9gknd 10209 6 blood blood NN cord-010119-t1x9gknd 10209 7 donors donor NNS cord-010119-t1x9gknd 10209 8 harbor harbor VBP cord-010119-t1x9gknd 10209 9 TTIs tti NNS cord-010119-t1x9gknd 10209 10 . . . cord-010119-t1x9gknd 10210 1 The the DT cord-010119-t1x9gknd 10210 2 NBB NBB NNP cord-010119-t1x9gknd 10210 3 center center NN cord-010119-t1x9gknd 10210 4 should should MD cord-010119-t1x9gknd 10210 5 work work VB cord-010119-t1x9gknd 10210 6 on on IN cord-010119-t1x9gknd 10210 7 voluntary voluntary JJ cord-010119-t1x9gknd 10210 8 blood blood NN cord-010119-t1x9gknd 10210 9 donor donor NN cord-010119-t1x9gknd 10210 10 mobilization mobilization NN cord-010119-t1x9gknd 10210 11 and and CC cord-010119-t1x9gknd 10210 12 develop develop VB cord-010119-t1x9gknd 10210 13 culture culture NN cord-010119-t1x9gknd 10210 14 of of IN cord-010119-t1x9gknd 10210 15 voluntarism voluntarism NN cord-010119-t1x9gknd 10210 16 . . . cord-010119-t1x9gknd 10211 1 The the DT cord-010119-t1x9gknd 10211 2 direct direct JJ cord-010119-t1x9gknd 10211 3 laboratory laboratory NN cord-010119-t1x9gknd 10211 4 cost cost NN cord-010119-t1x9gknd 10211 5 analysis analysis NN cord-010119-t1x9gknd 10211 6 using use VBG cord-010119-t1x9gknd 10211 7 current current JJ cord-010119-t1x9gknd 10211 8 in in IN cord-010119-t1x9gknd 10211 9 use use NN cord-010119-t1x9gknd 10211 10 strategy strategy NN cord-010119-t1x9gknd 10211 11 ( ( -LRB- cord-010119-t1x9gknd 10211 12 parallel parallel NN cord-010119-t1x9gknd 10211 13 ) ) -RRB- cord-010119-t1x9gknd 10211 14 was be VBD cord-010119-t1x9gknd 10211 15 higher high JJR cord-010119-t1x9gknd 10211 16 than than IN cord-010119-t1x9gknd 10211 17 the the DT cord-010119-t1x9gknd 10211 18 newly newly RB cord-010119-t1x9gknd 10211 19 designed design VBN cord-010119-t1x9gknd 10211 20 sequential sequential JJ cord-010119-t1x9gknd 10211 21 testing testing NN cord-010119-t1x9gknd 10211 22 algorithm algorithm NN cord-010119-t1x9gknd 10211 23 . . . cord-010119-t1x9gknd 10212 1 Thus thus RB cord-010119-t1x9gknd 10212 2 , , , cord-010119-t1x9gknd 10212 3 the the DT cord-010119-t1x9gknd 10212 4 new new JJ cord-010119-t1x9gknd 10212 5 strategy strategy NN cord-010119-t1x9gknd 10212 6 can can MD cord-010119-t1x9gknd 10212 7 be be VB cord-010119-t1x9gknd 10212 8 implemented implement VBN cord-010119-t1x9gknd 10212 9 to to TO cord-010119-t1x9gknd 10212 10 make make VB cord-010119-t1x9gknd 10212 11 screening screening NN cord-010119-t1x9gknd 10212 12 of of IN cord-010119-t1x9gknd 10212 13 TTIs tti NNS cord-010119-t1x9gknd 10212 14 cost cost VBP cord-010119-t1x9gknd 10212 15 effective effective JJ cord-010119-t1x9gknd 10212 16 in in IN cord-010119-t1x9gknd 10212 17 NBB NBB NNP cord-010119-t1x9gknd 10212 18 center center NN cord-010119-t1x9gknd 10212 19 . . . cord-010119-t1x9gknd 10213 1 Transfusion transfusion NN cord-010119-t1x9gknd 10213 2 Transmitted transmit VBD cord-010119-t1x9gknd 10213 3 Malaria Malaria NNP cord-010119-t1x9gknd 10213 4 in in IN cord-010119-t1x9gknd 10213 5 a a DT cord-010119-t1x9gknd 10213 6 14 14 CD cord-010119-t1x9gknd 10213 7 Month Month NNP cord-010119-t1x9gknd 10213 8 Old Old NNP cord-010119-t1x9gknd 10213 9 Infant Infant NNP cord-010119-t1x9gknd 10213 10 Patricia Patricia NNP cord-010119-t1x9gknd 10213 11 Davenport Davenport NNP cord-010119-t1x9gknd 10213 12 * * NFP cord-010119-t1x9gknd 10213 13 1 1 CD cord-010119-t1x9gknd 10213 14 , , , cord-010119-t1x9gknd 10213 15 Geeta Geeta NNP cord-010119-t1x9gknd 10213 16 Paranjape Paranjape NNP cord-010119-t1x9gknd 10213 17 1 1 CD cord-010119-t1x9gknd 10213 18 and and CC cord-010119-t1x9gknd 10213 19 Laurie Laurie NNP cord-010119-t1x9gknd 10213 20 Sutor Sutor NNP cord-010119-t1x9gknd 10214 1 1,2 1,2 LS cord-010119-t1x9gknd 10214 2 . . . cord-010119-t1x9gknd 10215 1 1 1 CD cord-010119-t1x9gknd 10215 2 Carter Carter NNP cord-010119-t1x9gknd 10215 3 BloodCare BloodCare NNP cord-010119-t1x9gknd 10215 4 , , , cord-010119-t1x9gknd 10215 5 2 2 CD cord-010119-t1x9gknd 10215 6 UT UT NNP cord-010119-t1x9gknd 10215 7 Southwestern Southwestern NNP cord-010119-t1x9gknd 10215 8 Medical Medical NNP cord-010119-t1x9gknd 10215 9 Center Center NNP cord-010119-t1x9gknd 10215 10 Background Background NNP cord-010119-t1x9gknd 10215 11 / / SYM cord-010119-t1x9gknd 10215 12 Case Case NNP cord-010119-t1x9gknd 10215 13 Studies Studies NNPS cord-010119-t1x9gknd 10215 14 : : : cord-010119-t1x9gknd 10216 1 In in IN cord-010119-t1x9gknd 10216 2 2017 2017 CD cord-010119-t1x9gknd 10216 3 at at IN cord-010119-t1x9gknd 10216 4 a a DT cord-010119-t1x9gknd 10216 5 large large JJ cord-010119-t1x9gknd 10216 6 pediatric pediatric JJ cord-010119-t1x9gknd 10216 7 hospital hospital NN cord-010119-t1x9gknd 10216 8 , , , cord-010119-t1x9gknd 10216 9 a a DT cord-010119-t1x9gknd 10216 10 14 14 CD cord-010119-t1x9gknd 10216 11 month month NN cord-010119-t1x9gknd 10216 12 old old JJ cord-010119-t1x9gknd 10216 13 infant infant NN cord-010119-t1x9gknd 10216 14 was be VBD cord-010119-t1x9gknd 10216 15 supported support VBN cord-010119-t1x9gknd 10216 16 for for IN cord-010119-t1x9gknd 10216 17 31 31 CD cord-010119-t1x9gknd 10216 18 days day NNS cord-010119-t1x9gknd 10216 19 by by IN cord-010119-t1x9gknd 10216 20 extracorporeal extracorporeal JJ cord-010119-t1x9gknd 10216 21 membrane membrane NN cord-010119-t1x9gknd 10216 22 oxygenation oxygenation NN cord-010119-t1x9gknd 10216 23 ( ( -LRB- cord-010119-t1x9gknd 10216 24 ECMO ECMO NNP cord-010119-t1x9gknd 10216 25 ) ) -RRB- cord-010119-t1x9gknd 10216 26 . . . cord-010119-t1x9gknd 10217 1 Over over IN cord-010119-t1x9gknd 10217 2 this this DT cord-010119-t1x9gknd 10217 3 time time NN cord-010119-t1x9gknd 10217 4 113 113 CD cord-010119-t1x9gknd 10217 5 blood blood NN cord-010119-t1x9gknd 10217 6 products product NNS cord-010119-t1x9gknd 10217 7 were be VBD cord-010119-t1x9gknd 10217 8 transfused transfuse VBN cord-010119-t1x9gknd 10217 9 . . . cord-010119-t1x9gknd 10218 1 About about RB cord-010119-t1x9gknd 10218 2 10 10 CD cord-010119-t1x9gknd 10218 3 days day NNS cord-010119-t1x9gknd 10218 4 after after IN cord-010119-t1x9gknd 10218 5 end end NN cord-010119-t1x9gknd 10218 6 of of IN cord-010119-t1x9gknd 10218 7 ECMO ECMO NNP cord-010119-t1x9gknd 10218 8 support support NN cord-010119-t1x9gknd 10218 9 , , , cord-010119-t1x9gknd 10218 10 a a DT cord-010119-t1x9gknd 10218 11 routine routine JJ cord-010119-t1x9gknd 10218 12 blood blood NN cord-010119-t1x9gknd 10218 13 smear smear NN cord-010119-t1x9gknd 10218 14 examination examination NN cord-010119-t1x9gknd 10218 15 revealed reveal VBD cord-010119-t1x9gknd 10218 16 inclusions inclusion NNS cord-010119-t1x9gknd 10218 17 in in IN cord-010119-t1x9gknd 10218 18 some some DT cord-010119-t1x9gknd 10218 19 of of IN cord-010119-t1x9gknd 10218 20 the the DT cord-010119-t1x9gknd 10218 21 patient patient NN cord-010119-t1x9gknd 10218 22 's 's POS cord-010119-t1x9gknd 10218 23 red red JJ cord-010119-t1x9gknd 10218 24 cells cell NNS cord-010119-t1x9gknd 10218 25 . . . cord-010119-t1x9gknd 10219 1 The the DT cord-010119-t1x9gknd 10219 2 patient patient NN cord-010119-t1x9gknd 10219 3 had have VBD cord-010119-t1x9gknd 10219 4 also also RB cord-010119-t1x9gknd 10219 5 been be VBN cord-010119-t1x9gknd 10219 6 having have VBG cord-010119-t1x9gknd 10219 7 intermittent intermittent JJ cord-010119-t1x9gknd 10219 8 fever fever NN cord-010119-t1x9gknd 10219 9 . . . cord-010119-t1x9gknd 10220 1 Malaria Malaria NNP cord-010119-t1x9gknd 10220 2 was be VBD cord-010119-t1x9gknd 10220 3 confirmed confirm VBN cord-010119-t1x9gknd 10220 4 by by IN cord-010119-t1x9gknd 10220 5 PCR PCR NNP cord-010119-t1x9gknd 10220 6 as as IN cord-010119-t1x9gknd 10220 7 Plasmodium Plasmodium NNP cord-010119-t1x9gknd 10220 8 ovale ovale NN cord-010119-t1x9gknd 10220 9 ( ( -LRB- cord-010119-t1x9gknd 10220 10 P. P. NNP cord-010119-t1x9gknd 10220 11 ovale ovale NN cord-010119-t1x9gknd 10220 12 ) ) -RRB- cord-010119-t1x9gknd 10220 13 . . . cord-010119-t1x9gknd 10221 1 Because because IN cord-010119-t1x9gknd 10221 2 the the DT cord-010119-t1x9gknd 10221 3 patient patient NN cord-010119-t1x9gknd 10221 4 had have VBD cord-010119-t1x9gknd 10221 5 no no DT cord-010119-t1x9gknd 10221 6 other other JJ cord-010119-t1x9gknd 10221 7 risks risk NNS cord-010119-t1x9gknd 10221 8 , , , cord-010119-t1x9gknd 10221 9 the the DT cord-010119-t1x9gknd 10221 10 infection infection NN cord-010119-t1x9gknd 10221 11 was be VBD cord-010119-t1x9gknd 10221 12 suspected suspect VBN cord-010119-t1x9gknd 10221 13 to to TO cord-010119-t1x9gknd 10221 14 be be VB cord-010119-t1x9gknd 10221 15 transfusion transfusion NN cord-010119-t1x9gknd 10221 16 related relate VBN cord-010119-t1x9gknd 10221 17 and and CC cord-010119-t1x9gknd 10221 18 was be VBD cord-010119-t1x9gknd 10221 19 reported report VBN cord-010119-t1x9gknd 10221 20 to to IN cord-010119-t1x9gknd 10221 21 our -PRON- PRP$ cord-010119-t1x9gknd 10221 22 blood blood NN cord-010119-t1x9gknd 10221 23 center center NN cord-010119-t1x9gknd 10221 24 which which WDT cord-010119-t1x9gknd 10221 25 had have VBD cord-010119-t1x9gknd 10221 26 supplied supply VBN cord-010119-t1x9gknd 10221 27 all all DT cord-010119-t1x9gknd 10221 28 transfused transfuse VBN cord-010119-t1x9gknd 10221 29 products product NNS cord-010119-t1x9gknd 10221 30 . . . cord-010119-t1x9gknd 10222 1 Study Study NNP cord-010119-t1x9gknd 10222 2 Design Design NNP cord-010119-t1x9gknd 10222 3 / / SYM cord-010119-t1x9gknd 10222 4 Method method NN cord-010119-t1x9gknd 10222 5 : : : cord-010119-t1x9gknd 10223 1 The the DT cord-010119-t1x9gknd 10223 2 investigation investigation NN cord-010119-t1x9gknd 10223 3 began begin VBD cord-010119-t1x9gknd 10223 4 by by IN cord-010119-t1x9gknd 10223 5 focusing focus VBG cord-010119-t1x9gknd 10223 6 on on IN cord-010119-t1x9gknd 10223 7 donors donor NNS cord-010119-t1x9gknd 10223 8 of of IN cord-010119-t1x9gknd 10223 9 red red JJ cord-010119-t1x9gknd 10223 10 cell cell NN cord-010119-t1x9gknd 10223 11 products product NNS cord-010119-t1x9gknd 10223 12 , , , cord-010119-t1x9gknd 10223 13 since since IN cord-010119-t1x9gknd 10223 14 the the DT cord-010119-t1x9gknd 10223 15 chance chance NN cord-010119-t1x9gknd 10223 16 of of IN cord-010119-t1x9gknd 10223 17 an an DT cord-010119-t1x9gknd 10223 18 apheresis apheresis NN cord-010119-t1x9gknd 10223 19 platelet platelet NN cord-010119-t1x9gknd 10223 20 product product NN cord-010119-t1x9gknd 10223 21 transmitting transmit VBG cord-010119-t1x9gknd 10223 22 malaria malaria NN cord-010119-t1x9gknd 10223 23 is be VBZ cord-010119-t1x9gknd 10223 24 relatively relatively RB cord-010119-t1x9gknd 10223 25 small small JJ cord-010119-t1x9gknd 10223 26 , , , cord-010119-t1x9gknd 10223 27 and and CC cord-010119-t1x9gknd 10223 28 that that DT cord-010119-t1x9gknd 10223 29 of of IN cord-010119-t1x9gknd 10223 30 a a DT cord-010119-t1x9gknd 10223 31 frozen frozen JJ cord-010119-t1x9gknd 10223 32 product product NN cord-010119-t1x9gknd 10223 33 is be VBZ cord-010119-t1x9gknd 10223 34 remote remote JJ cord-010119-t1x9gknd 10223 35 . . . cord-010119-t1x9gknd 10224 1 We -PRON- PRP cord-010119-t1x9gknd 10224 2 identified identify VBD cord-010119-t1x9gknd 10224 3 27 27 CD cord-010119-t1x9gknd 10224 4 donors donor NNS cord-010119-t1x9gknd 10224 5 of of IN cord-010119-t1x9gknd 10224 6 red red JJ cord-010119-t1x9gknd 10224 7 cell cell NN cord-010119-t1x9gknd 10224 8 products product NNS cord-010119-t1x9gknd 10224 9 . . . cord-010119-t1x9gknd 10225 1 Each each DT cord-010119-t1x9gknd 10225 2 donor donor NN cord-010119-t1x9gknd 10225 3 was be VBD cord-010119-t1x9gknd 10225 4 contacted contact VBN cord-010119-t1x9gknd 10225 5 and and CC cord-010119-t1x9gknd 10225 6 was be VBD cord-010119-t1x9gknd 10225 7 asked ask VBN cord-010119-t1x9gknd 10225 8 four four CD cord-010119-t1x9gknd 10225 9 questions question NNS cord-010119-t1x9gknd 10225 10 . . . cord-010119-t1x9gknd 10226 1 Additional additional JJ cord-010119-t1x9gknd 10226 2 questions question NNS cord-010119-t1x9gknd 10226 3 were be VBD cord-010119-t1x9gknd 10226 4 asked ask VBN cord-010119-t1x9gknd 10226 5 for for IN cord-010119-t1x9gknd 10226 6 clarification clarification NN cord-010119-t1x9gknd 10226 7 if if IN cord-010119-t1x9gknd 10226 8 needed need VBN cord-010119-t1x9gknd 10226 9 . . . cord-010119-t1x9gknd 10227 1 Based base VBN cord-010119-t1x9gknd 10227 2 on on IN cord-010119-t1x9gknd 10227 3 donor donor NN cord-010119-t1x9gknd 10227 4 response response NN cord-010119-t1x9gknd 10227 5 , , , cord-010119-t1x9gknd 10227 6 risk risk NN cord-010119-t1x9gknd 10227 7 for for IN cord-010119-t1x9gknd 10227 8 active active JJ cord-010119-t1x9gknd 10227 9 malaria malaria NN cord-010119-t1x9gknd 10227 10 infection infection NN cord-010119-t1x9gknd 10227 11 was be VBD cord-010119-t1x9gknd 10227 12 assessed assess VBN cord-010119-t1x9gknd 10227 13 . . . cord-010119-t1x9gknd 10228 1 We -PRON- PRP cord-010119-t1x9gknd 10228 2 also also RB cord-010119-t1x9gknd 10228 3 considered consider VBD cord-010119-t1x9gknd 10228 4 areas area NNS cord-010119-t1x9gknd 10228 5 where where WRB cord-010119-t1x9gknd 10228 6 P. P. NNP cord-010119-t1x9gknd 10228 7 ovale ovale NN cord-010119-t1x9gknd 10228 8 is be VBZ cord-010119-t1x9gknd 10228 9 , , , cord-010119-t1x9gknd 10228 10 or or CC cord-010119-t1x9gknd 10228 11 is be VBZ cord-010119-t1x9gknd 10228 12 not not RB cord-010119-t1x9gknd 10228 13 found find VBN cord-010119-t1x9gknd 10228 14 . . . cord-010119-t1x9gknd 10229 1 Donors donor NNS cord-010119-t1x9gknd 10229 2 identified identify VBN cord-010119-t1x9gknd 10229 3 as as IN cord-010119-t1x9gknd 10229 4 having have VBG cord-010119-t1x9gknd 10229 5 possible possible JJ cord-010119-t1x9gknd 10229 6 risk risk NN cord-010119-t1x9gknd 10229 7 were be VBD cord-010119-t1x9gknd 10229 8 tested test VBN cord-010119-t1x9gknd 10229 9 for for IN cord-010119-t1x9gknd 10229 10 antibodies antibody NNS cord-010119-t1x9gknd 10229 11 and and CC cord-010119-t1x9gknd 10229 12 parasitic parasitic JJ cord-010119-t1x9gknd 10229 13 DNA dna NN cord-010119-t1x9gknd 10229 14 . . . cord-010119-t1x9gknd 10230 1 Results/ Results/ . cord-010119-t1x9gknd 10231 1 Finding finding NN cord-010119-t1x9gknd 10231 2 : : : cord-010119-t1x9gknd 10232 1 The the DT cord-010119-t1x9gknd 10232 2 five five CD cord-010119-t1x9gknd 10232 3 donors donor NNS cord-010119-t1x9gknd 10232 4 who who WP cord-010119-t1x9gknd 10232 5 had have VBD cord-010119-t1x9gknd 10232 6 been be VBN cord-010119-t1x9gknd 10232 7 ill ill RB cord-010119-t1x9gknd 10232 8 all all DT cord-010119-t1x9gknd 10232 9 had have VBD cord-010119-t1x9gknd 10232 10 common common JJ cord-010119-t1x9gknd 10232 11 cold cold NN cord-010119-t1x9gknd 10232 12 or or CC cord-010119-t1x9gknd 10232 13 bronchitis bronchitis NN cord-010119-t1x9gknd 10232 14 like like IN cord-010119-t1x9gknd 10232 15 symptoms symptom NNS cord-010119-t1x9gknd 10232 16 . . . cord-010119-t1x9gknd 10233 1 Donors donor NNS cord-010119-t1x9gknd 10233 2 who who WP cord-010119-t1x9gknd 10233 3 traveled travel VBD cord-010119-t1x9gknd 10233 4 went go VBD cord-010119-t1x9gknd 10233 5 only only RB cord-010119-t1x9gknd 10233 6 to to IN cord-010119-t1x9gknd 10233 7 non non JJ cord-010119-t1x9gknd 10233 8 - - JJ cord-010119-t1x9gknd 10233 9 risk risk JJ cord-010119-t1x9gknd 10233 10 areas area NNS cord-010119-t1x9gknd 10233 11 . . . cord-010119-t1x9gknd 10234 1 Three three CD cord-010119-t1x9gknd 10234 2 donors donor NNS cord-010119-t1x9gknd 10234 3 were be VBD cord-010119-t1x9gknd 10234 4 former former JJ cord-010119-t1x9gknd 10234 5 residents resident NNS cord-010119-t1x9gknd 10234 6 of of IN cord-010119-t1x9gknd 10234 7 another another DT cord-010119-t1x9gknd 10234 8 country country NN cord-010119-t1x9gknd 10234 9 and and CC cord-010119-t1x9gknd 10234 10 may may MD cord-010119-t1x9gknd 10234 11 have have VB cord-010119-t1x9gknd 10234 12 risk risk NN cord-010119-t1x9gknd 10234 13 because because IN cord-010119-t1x9gknd 10234 14 they -PRON- PRP cord-010119-t1x9gknd 10234 15 lived live VBD cord-010119-t1x9gknd 10234 16 in in IN cord-010119-t1x9gknd 10234 17 malaria malaria NN cord-010119-t1x9gknd 10234 18 endemic endemic JJ cord-010119-t1x9gknd 10234 19 countries country NNS cord-010119-t1x9gknd 10234 20 since since IN cord-010119-t1x9gknd 10234 21 birth birth NN cord-010119-t1x9gknd 10234 22 and and CC cord-010119-t1x9gknd 10234 23 came come VBD cord-010119-t1x9gknd 10234 24 to to IN cord-010119-t1x9gknd 10234 25 the the DT cord-010119-t1x9gknd 10234 26 U.S. U.S. NNP cord-010119-t1x9gknd 10234 27 as as IN cord-010119-t1x9gknd 10234 28 adults adult NNS cord-010119-t1x9gknd 10234 29 . . . cord-010119-t1x9gknd 10235 1 It -PRON- PRP cord-010119-t1x9gknd 10235 2 was be VBD cord-010119-t1x9gknd 10235 3 discovered discover VBN cord-010119-t1x9gknd 10235 4 that that IN cord-010119-t1x9gknd 10235 5 one one CD cord-010119-t1x9gknd 10235 6 of of IN cord-010119-t1x9gknd 10235 7 these these DT cord-010119-t1x9gknd 10235 8 three three CD cord-010119-t1x9gknd 10235 9 did do VBD cord-010119-t1x9gknd 10235 10 not not RB cord-010119-t1x9gknd 10235 11 meet meet VB cord-010119-t1x9gknd 10235 12 all all DT cord-010119-t1x9gknd 10235 13 donor donor NN cord-010119-t1x9gknd 10235 14 criteria criterion NNS cord-010119-t1x9gknd 10235 15 . . . cord-010119-t1x9gknd 10236 1 The the DT cord-010119-t1x9gknd 10236 2 donor donor NN cord-010119-t1x9gknd 10236 3 had have VBD cord-010119-t1x9gknd 10236 4 failed fail VBN cord-010119-t1x9gknd 10236 5 to to TO cord-010119-t1x9gknd 10236 6 disclose disclose VB cord-010119-t1x9gknd 10236 7 that that IN cord-010119-t1x9gknd 10236 8 he -PRON- PRP cord-010119-t1x9gknd 10236 9 had have VBD cord-010119-t1x9gknd 10236 10 not not RB cord-010119-t1x9gknd 10236 11 completed complete VBN cord-010119-t1x9gknd 10236 12 3 3 CD cord-010119-t1x9gknd 10236 13 years year NNS cord-010119-t1x9gknd 10236 14 stay stay VB cord-010119-t1x9gknd 10236 15 in in IN cord-010119-t1x9gknd 10236 16 the the DT cord-010119-t1x9gknd 10236 17 U.S. U.S. NNP cord-010119-t1x9gknd 10236 18 after after IN cord-010119-t1x9gknd 10236 19 emigrating emigrate VBG cord-010119-t1x9gknd 10236 20 from from IN cord-010119-t1x9gknd 10236 21 Cameroon Cameroon NNP cord-010119-t1x9gknd 10236 22 , , , cord-010119-t1x9gknd 10236 23 an an DT cord-010119-t1x9gknd 10236 24 area area NN cord-010119-t1x9gknd 10236 25 endemic endemic JJ cord-010119-t1x9gknd 10236 26 for for IN cord-010119-t1x9gknd 10236 27 P. P. NNP cord-010119-t1x9gknd 10236 28 ovale ovale NN cord-010119-t1x9gknd 10236 29 . . . cord-010119-t1x9gknd 10237 1 He -PRON- PRP cord-010119-t1x9gknd 10237 2 had have VBD cord-010119-t1x9gknd 10237 3 not not RB cord-010119-t1x9gknd 10237 4 travelled travel VBN cord-010119-t1x9gknd 10237 5 anywhere anywhere RB cord-010119-t1x9gknd 10237 6 after after IN cord-010119-t1x9gknd 10237 7 coming come VBG cord-010119-t1x9gknd 10237 8 to to IN cord-010119-t1x9gknd 10237 9 the the DT cord-010119-t1x9gknd 10237 10 United United NNP cord-010119-t1x9gknd 10237 11 States States NNP cord-010119-t1x9gknd 10237 12 in in IN cord-010119-t1x9gknd 10237 13 October October NNP cord-010119-t1x9gknd 10237 14 2014 2014 CD cord-010119-t1x9gknd 10237 15 and and CC cord-010119-t1x9gknd 10237 16 answered answer VBD cord-010119-t1x9gknd 10237 17 " " `` cord-010119-t1x9gknd 10237 18 No no UH cord-010119-t1x9gknd 10237 19 " " '' cord-010119-t1x9gknd 10237 20 to to TO cord-010119-t1x9gknd 10237 21 travel travel VB cord-010119-t1x9gknd 10237 22 . . . cord-010119-t1x9gknd 10238 1 Antibody antibody NN cord-010119-t1x9gknd 10238 2 tests test NNS cord-010119-t1x9gknd 10238 3 on on IN cord-010119-t1x9gknd 10238 4 this this DT cord-010119-t1x9gknd 10238 5 donor donor NN cord-010119-t1x9gknd 10238 6 were be VBD cord-010119-t1x9gknd 10238 7 positive positive JJ cord-010119-t1x9gknd 10238 8 for for IN cord-010119-t1x9gknd 10238 9 P. P. NNP cord-010119-t1x9gknd 10238 10 ovale ovale NN cord-010119-t1x9gknd 10238 11 and and CC cord-010119-t1x9gknd 10238 12 P. P. NNP cord-010119-t1x9gknd 10238 13 falciparum falciparum NNS cord-010119-t1x9gknd 10238 14 , , , cord-010119-t1x9gknd 10238 15 but but CC cord-010119-t1x9gknd 10238 16 PCR PCR NNP cord-010119-t1x9gknd 10238 17 tests test NNS cord-010119-t1x9gknd 10238 18 were be VBD cord-010119-t1x9gknd 10238 19 negative negative JJ cord-010119-t1x9gknd 10238 20 . . . cord-010119-t1x9gknd 10239 1 Another another DT cord-010119-t1x9gknd 10239 2 possible possible JJ cord-010119-t1x9gknd 10239 3 at at IN cord-010119-t1x9gknd 10239 4 - - HYPH cord-010119-t1x9gknd 10239 5 risk risk NN cord-010119-t1x9gknd 10239 6 donor donor NN cord-010119-t1x9gknd 10239 7 , , , cord-010119-t1x9gknd 10239 8 a a DT cord-010119-t1x9gknd 10239 9 former former JJ cord-010119-t1x9gknd 10239 10 resident resident NN cord-010119-t1x9gknd 10239 11 of of IN cord-010119-t1x9gknd 10239 12 Iran Iran NNP cord-010119-t1x9gknd 10239 13 was be VBD cord-010119-t1x9gknd 10239 14 tested test VBN cord-010119-t1x9gknd 10239 15 and and CC cord-010119-t1x9gknd 10239 16 was be VBD cord-010119-t1x9gknd 10239 17 PCR PCR NNP cord-010119-t1x9gknd 10239 18 and and CC cord-010119-t1x9gknd 10239 19 antibody antibody NN cord-010119-t1x9gknd 10239 20 negative negative JJ cord-010119-t1x9gknd 10239 21 . . . cord-010119-t1x9gknd 10240 1 The the DT cord-010119-t1x9gknd 10240 2 third third JJ cord-010119-t1x9gknd 10240 3 donor donor NN cord-010119-t1x9gknd 10240 4 has have VBZ cord-010119-t1x9gknd 10240 5 not not RB cord-010119-t1x9gknd 10240 6 yet yet RB cord-010119-t1x9gknd 10240 7 been be VBN cord-010119-t1x9gknd 10240 8 tested test VBN cord-010119-t1x9gknd 10240 9 but but CC cord-010119-t1x9gknd 10240 10 the the DT cord-010119-t1x9gknd 10240 11 country country NN cord-010119-t1x9gknd 10240 12 of of IN cord-010119-t1x9gknd 10240 13 residence residence NN cord-010119-t1x9gknd 10240 14 does do VBZ cord-010119-t1x9gknd 10240 15 not not RB cord-010119-t1x9gknd 10240 16 have have VB cord-010119-t1x9gknd 10240 17 P. P. NNP cord-010119-t1x9gknd 10240 18 ovale ovale NN cord-010119-t1x9gknd 10240 19 malaria malaria NN cord-010119-t1x9gknd 10240 20 . . . cord-010119-t1x9gknd 10241 1 Conclusion conclusion NN cord-010119-t1x9gknd 10241 2 : : : cord-010119-t1x9gknd 10241 3 While while IN cord-010119-t1x9gknd 10241 4 it -PRON- PRP cord-010119-t1x9gknd 10241 5 could could MD cord-010119-t1x9gknd 10241 6 not not RB cord-010119-t1x9gknd 10241 7 be be VB cord-010119-t1x9gknd 10241 8 definitively definitively RB cord-010119-t1x9gknd 10241 9 proven prove VBN cord-010119-t1x9gknd 10241 10 that that IN cord-010119-t1x9gknd 10241 11 the the DT cord-010119-t1x9gknd 10241 12 donor donor NN cord-010119-t1x9gknd 10241 13 with with IN cord-010119-t1x9gknd 10241 14 antibodies antibody NNS cord-010119-t1x9gknd 10241 15 to to IN cord-010119-t1x9gknd 10241 16 P. P. NNP cord-010119-t1x9gknd 10241 17 ovale ovale NNP cord-010119-t1x9gknd 10241 18 had have VBD cord-010119-t1x9gknd 10241 19 active active JJ cord-010119-t1x9gknd 10241 20 malaria malaria NN cord-010119-t1x9gknd 10241 21 at at IN cord-010119-t1x9gknd 10241 22 the the DT cord-010119-t1x9gknd 10241 23 time time NN cord-010119-t1x9gknd 10241 24 of of IN cord-010119-t1x9gknd 10241 25 donation donation NN cord-010119-t1x9gknd 10241 26 , , , cord-010119-t1x9gknd 10241 27 the the DT cord-010119-t1x9gknd 10241 28 donor donor NN cord-010119-t1x9gknd 10241 29 was be VBD cord-010119-t1x9gknd 10241 30 indefinitely indefinitely RB cord-010119-t1x9gknd 10241 31 deferred defer VBN cord-010119-t1x9gknd 10241 32 and and CC cord-010119-t1x9gknd 10241 33 referred refer VBD cord-010119-t1x9gknd 10241 34 to to IN cord-010119-t1x9gknd 10241 35 an an DT cord-010119-t1x9gknd 10241 36 outside outside JJ cord-010119-t1x9gknd 10241 37 physician physician NN cord-010119-t1x9gknd 10241 38 for for IN cord-010119-t1x9gknd 10241 39 treatment treatment NN cord-010119-t1x9gknd 10241 40 . . . cord-010119-t1x9gknd 10242 1 Transfusion transfusion NN cord-010119-t1x9gknd 10242 2 - - HYPH cord-010119-t1x9gknd 10242 3 Transmitted transmit VBN cord-010119-t1x9gknd 10242 4 Babesiosis babesiosis NN cord-010119-t1x9gknd 10242 5 Outside outside IN cord-010119-t1x9gknd 10242 6 an an DT cord-010119-t1x9gknd 10242 7 Endemic Endemic NNP cord-010119-t1x9gknd 10242 8 Area area NN cord-010119-t1x9gknd 10243 1 : : : cord-010119-t1x9gknd 10243 2 A a DT cord-010119-t1x9gknd 10243 3 Case case NN cord-010119-t1x9gknd 10243 4 Report report NN cord-010119-t1x9gknd 10244 1 German German NNP cord-010119-t1x9gknd 10244 2 Felix Felix NNP cord-010119-t1x9gknd 10244 3 Leparc Leparc NNP cord-010119-t1x9gknd 10245 1 * * NFP cord-010119-t1x9gknd 10245 2 . . . cord-010119-t1x9gknd 10246 1 OneBlood OneBlood NNP cord-010119-t1x9gknd 10246 2 Background Background NNP cord-010119-t1x9gknd 10246 3 / / SYM cord-010119-t1x9gknd 10246 4 Case Case NNP cord-010119-t1x9gknd 10246 5 Studies Studies NNPS cord-010119-t1x9gknd 10246 6 : : : cord-010119-t1x9gknd 10247 1 An an DT cord-010119-t1x9gknd 10247 2 81 81 CD cord-010119-t1x9gknd 10247 3 y.o y.o NNP cord-010119-t1x9gknd 10247 4 . . NNP cord-010119-t1x9gknd 10247 5 male male JJ cord-010119-t1x9gknd 10247 6 patient patient NN cord-010119-t1x9gknd 10247 7 was be VBD cord-010119-t1x9gknd 10247 8 admitted admit VBN cord-010119-t1x9gknd 10247 9 to to IN cord-010119-t1x9gknd 10247 10 the the DT cord-010119-t1x9gknd 10247 11 Emergency Emergency NNP cord-010119-t1x9gknd 10247 12 Room Room NNP cord-010119-t1x9gknd 10247 13 for for IN cord-010119-t1x9gknd 10247 14 severe severe JJ cord-010119-t1x9gknd 10247 15 acute acute JJ cord-010119-t1x9gknd 10247 16 gastrointestinal gastrointestinal JJ cord-010119-t1x9gknd 10247 17 bleeding bleeding NN cord-010119-t1x9gknd 10247 18 , , , cord-010119-t1x9gknd 10247 19 caused cause VBN cord-010119-t1x9gknd 10247 20 by by IN cord-010119-t1x9gknd 10247 21 an an DT cord-010119-t1x9gknd 10247 22 arterio arterio NN cord-010119-t1x9gknd 10247 23 - - HYPH cord-010119-t1x9gknd 10247 24 venous venous JJ cord-010119-t1x9gknd 10247 25 malformation malformation NN cord-010119-t1x9gknd 10247 26 later later RB cord-010119-t1x9gknd 10247 27 located locate VBN cord-010119-t1x9gknd 10247 28 in in IN cord-010119-t1x9gknd 10247 29 the the DT cord-010119-t1x9gknd 10247 30 proximal proximal JJ cord-010119-t1x9gknd 10247 31 jejunum jejunum NNS cord-010119-t1x9gknd 10247 32 that that WDT cord-010119-t1x9gknd 10247 33 was be VBD cord-010119-t1x9gknd 10247 34 clipped clip VBN cord-010119-t1x9gknd 10247 35 endoscopically endoscopically RB cord-010119-t1x9gknd 10247 36 . . . cord-010119-t1x9gknd 10248 1 During during IN cord-010119-t1x9gknd 10248 2 this this DT cord-010119-t1x9gknd 10248 3 admission admission NN cord-010119-t1x9gknd 10248 4 , , , cord-010119-t1x9gknd 10248 5 he -PRON- PRP cord-010119-t1x9gknd 10248 6 received receive VBD cord-010119-t1x9gknd 10248 7 a a DT cord-010119-t1x9gknd 10248 8 total total NN cord-010119-t1x9gknd 10248 9 of of IN cord-010119-t1x9gknd 10248 10 13 13 CD cord-010119-t1x9gknd 10248 11 units unit NNS cord-010119-t1x9gknd 10248 12 of of IN cord-010119-t1x9gknd 10248 13 Red Red NNP cord-010119-t1x9gknd 10248 14 Blood Blood NNP cord-010119-t1x9gknd 10248 15 Cells cell NNS cord-010119-t1x9gknd 10248 16 . . . cord-010119-t1x9gknd 10249 1 Approximately approximately RB cord-010119-t1x9gknd 10249 2 4 4 CD cord-010119-t1x9gknd 10249 3 weeks week NNS cord-010119-t1x9gknd 10249 4 later later RB cord-010119-t1x9gknd 10249 5 , , , cord-010119-t1x9gknd 10249 6 he -PRON- PRP cord-010119-t1x9gknd 10249 7 was be VBD cord-010119-t1x9gknd 10249 8 re re VBN cord-010119-t1x9gknd 10249 9 - - VBN cord-010119-t1x9gknd 10249 10 admitted admit VBN cord-010119-t1x9gknd 10250 1 due due IN cord-010119-t1x9gknd 10250 2 to to IN cord-010119-t1x9gknd 10250 3 another another DT cord-010119-t1x9gknd 10250 4 episode episode NN cord-010119-t1x9gknd 10250 5 of of IN cord-010119-t1x9gknd 10250 6 GI GI NNP cord-010119-t1x9gknd 10250 7 bleed bleed NN cord-010119-t1x9gknd 10250 8 manifested manifest VBN cord-010119-t1x9gknd 10250 9 by by IN cord-010119-t1x9gknd 10250 10 melena melena NN cord-010119-t1x9gknd 10250 11 . . . cord-010119-t1x9gknd 10251 1 As as IN cord-010119-t1x9gknd 10251 2 part part NN cord-010119-t1x9gknd 10251 3 of of IN cord-010119-t1x9gknd 10251 4 his -PRON- PRP$ cord-010119-t1x9gknd 10251 5 routine routine JJ cord-010119-t1x9gknd 10251 6 evaluation evaluation NN cord-010119-t1x9gknd 10251 7 , , , cord-010119-t1x9gknd 10251 8 a a DT cord-010119-t1x9gknd 10251 9 CBC CBC NNP cord-010119-t1x9gknd 10251 10 was be VBD cord-010119-t1x9gknd 10251 11 performed perform VBN cord-010119-t1x9gknd 10251 12 in in IN cord-010119-t1x9gknd 10251 13 which which WDT cord-010119-t1x9gknd 10251 14 a a DT cord-010119-t1x9gknd 10251 15 blood blood NN cord-010119-t1x9gknd 10251 16 smear smear NN cord-010119-t1x9gknd 10251 17 revealed reveal VBD cord-010119-t1x9gknd 10251 18 the the DT cord-010119-t1x9gknd 10251 19 presence presence NN cord-010119-t1x9gknd 10251 20 of of IN cord-010119-t1x9gknd 10251 21 intraerythrocytic intraerythrocytic JJ cord-010119-t1x9gknd 10251 22 parasites parasite NNS cord-010119-t1x9gknd 10251 23 consistent consistent JJ cord-010119-t1x9gknd 10251 24 with with IN cord-010119-t1x9gknd 10251 25 Babesia Babesia NNP cord-010119-t1x9gknd 10251 26 sp sp NN cord-010119-t1x9gknd 10251 27 . . . cord-010119-t1x9gknd 10252 1 Study Study NNP cord-010119-t1x9gknd 10252 2 Design Design NNP cord-010119-t1x9gknd 10252 3 / / SYM cord-010119-t1x9gknd 10252 4 Method method NN cord-010119-t1x9gknd 10252 5 : : : cord-010119-t1x9gknd 10252 6 Upon upon IN cord-010119-t1x9gknd 10252 7 notification notification NN cord-010119-t1x9gknd 10252 8 of of IN cord-010119-t1x9gknd 10252 9 a a DT cord-010119-t1x9gknd 10252 10 suspected suspect VBN cord-010119-t1x9gknd 10252 11 case case NN cord-010119-t1x9gknd 10252 12 of of IN cord-010119-t1x9gknd 10252 13 Transfusion transfusion NN cord-010119-t1x9gknd 10252 14 - - HYPH cord-010119-t1x9gknd 10252 15 Transmitted transmit VBN cord-010119-t1x9gknd 10252 16 Babesiosis Babesiosis NNP cord-010119-t1x9gknd 10252 17 , , , cord-010119-t1x9gknd 10252 18 lookback lookback NN cord-010119-t1x9gknd 10252 19 of of IN cord-010119-t1x9gknd 10252 20 all all DT cord-010119-t1x9gknd 10252 21 donors donor NNS cord-010119-t1x9gknd 10252 22 involved involve VBN cord-010119-t1x9gknd 10252 23 in in IN cord-010119-t1x9gknd 10252 24 prior prior JJ cord-010119-t1x9gknd 10252 25 transfusion transfusion NN cord-010119-t1x9gknd 10252 26 event event NN cord-010119-t1x9gknd 10252 27 was be VBD cord-010119-t1x9gknd 10252 28 initiated initiate VBN cord-010119-t1x9gknd 10252 29 . . . cord-010119-t1x9gknd 10253 1 Results result NNS cord-010119-t1x9gknd 10253 2 / / SYM cord-010119-t1x9gknd 10253 3 Finding finding NN cord-010119-t1x9gknd 10253 4 : : : cord-010119-t1x9gknd 10254 1 To to TO cord-010119-t1x9gknd 10254 2 confirm confirm VB cord-010119-t1x9gknd 10254 3 the the DT cord-010119-t1x9gknd 10254 4 presumptive presumptive JJ cord-010119-t1x9gknd 10254 5 diagnosis diagnosis NN cord-010119-t1x9gknd 10254 6 of of IN cord-010119-t1x9gknd 10254 7 babesiosis babesiosis NN cord-010119-t1x9gknd 10254 8 , , , cord-010119-t1x9gknd 10254 9 PCR PCR NNP cord-010119-t1x9gknd 10254 10 was be VBD cord-010119-t1x9gknd 10254 11 performed perform VBN cord-010119-t1x9gknd 10254 12 and and CC cord-010119-t1x9gknd 10254 13 Babesia Babesia NNP cord-010119-t1x9gknd 10254 14 microti microti NN cord-010119-t1x9gknd 10254 15 DNA DNA NNP cord-010119-t1x9gknd 10254 16 was be VBD cord-010119-t1x9gknd 10254 17 detected detect VBN cord-010119-t1x9gknd 10254 18 . . . cord-010119-t1x9gknd 10255 1 An an DT cord-010119-t1x9gknd 10255 2 evaluation evaluation NN cord-010119-t1x9gknd 10255 3 of of IN cord-010119-t1x9gknd 10255 4 the the DT cord-010119-t1x9gknd 10255 5 patient patient NN cord-010119-t1x9gknd 10255 6 's 's POS cord-010119-t1x9gknd 10255 7 risk risk NN cord-010119-t1x9gknd 10255 8 factors factor NNS cord-010119-t1x9gknd 10255 9 revealed reveal VBD cord-010119-t1x9gknd 10255 10 that that IN cord-010119-t1x9gknd 10255 11 prior prior RB cord-010119-t1x9gknd 10255 12 to to IN cord-010119-t1x9gknd 10255 13 the the DT cord-010119-t1x9gknd 10255 14 GI GI NNP cord-010119-t1x9gknd 10255 15 bleed bleed VB cord-010119-t1x9gknd 10255 16 episode episode NN cord-010119-t1x9gknd 10255 17 for for IN cord-010119-t1x9gknd 10255 18 which which WDT cord-010119-t1x9gknd 10255 19 he -PRON- PRP cord-010119-t1x9gknd 10255 20 received receive VBD cord-010119-t1x9gknd 10255 21 transfusions transfusion NNS cord-010119-t1x9gknd 10255 22 , , , cord-010119-t1x9gknd 10255 23 eight eight CD cord-010119-t1x9gknd 10255 24 months month NNS cord-010119-t1x9gknd 10255 25 earlier early RBR cord-010119-t1x9gknd 10255 26 he -PRON- PRP cord-010119-t1x9gknd 10255 27 was be VBD cord-010119-t1x9gknd 10255 28 also also RB cord-010119-t1x9gknd 10255 29 transfused transfuse VBN cord-010119-t1x9gknd 10255 30 during during IN cord-010119-t1x9gknd 10255 31 open open JJ cord-010119-t1x9gknd 10255 32 heart heart NN cord-010119-t1x9gknd 10255 33 surgery surgery NN cord-010119-t1x9gknd 10255 34 . . . cord-010119-t1x9gknd 10256 1 No no DT cord-010119-t1x9gknd 10256 2 travel travel NN cord-010119-t1x9gknd 10256 3 history history NN cord-010119-t1x9gknd 10256 4 to to IN cord-010119-t1x9gknd 10256 5 the the DT cord-010119-t1x9gknd 10256 6 US US NNP cord-010119-t1x9gknd 10256 7 Midwest Midwest NNP cord-010119-t1x9gknd 10256 8 , , , cord-010119-t1x9gknd 10256 9 and and CC cord-010119-t1x9gknd 10256 10 while while IN cord-010119-t1x9gknd 10256 11 he -PRON- PRP cord-010119-t1x9gknd 10256 12 travelled travel VBD cord-010119-t1x9gknd 10256 13 to to IN cord-010119-t1x9gknd 10256 14 New New NNP cord-010119-t1x9gknd 10256 15 England England NNP cord-010119-t1x9gknd 10256 16 two two CD cord-010119-t1x9gknd 10256 17 years year NNS cord-010119-t1x9gknd 10256 18 ago ago RB cord-010119-t1x9gknd 10256 19 he -PRON- PRP cord-010119-t1x9gknd 10256 20 did do VBD cord-010119-t1x9gknd 10256 21 not not RB cord-010119-t1x9gknd 10256 22 spend spend VB cord-010119-t1x9gknd 10256 23 time time NN cord-010119-t1x9gknd 10256 24 outdoors outdoors RB cord-010119-t1x9gknd 10256 25 . . . cord-010119-t1x9gknd 10257 1 He -PRON- PRP cord-010119-t1x9gknd 10257 2 was be VBD cord-010119-t1x9gknd 10257 3 splenectomized splenectomize VBN cord-010119-t1x9gknd 10257 4 in in IN cord-010119-t1x9gknd 10257 5 his -PRON- PRP$ cord-010119-t1x9gknd 10257 6 mid mid NNP cord-010119-t1x9gknd 10257 7 20 20 CD cord-010119-t1x9gknd 10257 8 's 's POS cord-010119-t1x9gknd 10257 9 . . . cord-010119-t1x9gknd 10258 1 Donor donor NN cord-010119-t1x9gknd 10258 2 lookback lookback NN cord-010119-t1x9gknd 10258 3 identified identify VBD cord-010119-t1x9gknd 10258 4 a a DT cord-010119-t1x9gknd 10258 5 donor donor NN cord-010119-t1x9gknd 10258 6 who who WP cord-010119-t1x9gknd 10258 7 lived live VBD cord-010119-t1x9gknd 10258 8 in in IN cord-010119-t1x9gknd 10258 9 New New NNP cord-010119-t1x9gknd 10258 10 London London NNP cord-010119-t1x9gknd 10258 11 County County NNP cord-010119-t1x9gknd 10258 12 , , , cord-010119-t1x9gknd 10258 13 Connecticut Connecticut NNP cord-010119-t1x9gknd 10258 14 but but CC cord-010119-t1x9gknd 10258 15 spent spend VBD cord-010119-t1x9gknd 10258 16 the the DT cord-010119-t1x9gknd 10258 17 winter winter NN cord-010119-t1x9gknd 10258 18 season season NN cord-010119-t1x9gknd 10258 19 in in IN cord-010119-t1x9gknd 10258 20 Central Central NNP cord-010119-t1x9gknd 10258 21 Florida Florida NNP cord-010119-t1x9gknd 10258 22 , , , cord-010119-t1x9gknd 10258 23 where where WRB cord-010119-t1x9gknd 10258 24 the the DT cord-010119-t1x9gknd 10258 25 blood blood NN cord-010119-t1x9gknd 10258 26 donation donation NN cord-010119-t1x9gknd 10258 27 ( ( -LRB- cord-010119-t1x9gknd 10258 28 double double JJ cord-010119-t1x9gknd 10258 29 RBC RBC NNP cord-010119-t1x9gknd 10258 30 collected collect VBN cord-010119-t1x9gknd 10258 31 by by IN cord-010119-t1x9gknd 10258 32 apheresis apheresis NN cord-010119-t1x9gknd 10258 33 ) ) -RRB- cord-010119-t1x9gknd 10258 34 took take VBD cord-010119-t1x9gknd 10258 35 place place NN cord-010119-t1x9gknd 10258 36 . . . cord-010119-t1x9gknd 10259 1 He -PRON- PRP cord-010119-t1x9gknd 10259 2 had have VBD cord-010119-t1x9gknd 10259 3 never never RB cord-010119-t1x9gknd 10259 4 been be VBN cord-010119-t1x9gknd 10259 5 diagnosed diagnose VBN cord-010119-t1x9gknd 10259 6 with with IN cord-010119-t1x9gknd 10259 7 babesiosis babesiosis NN cord-010119-t1x9gknd 10259 8 , , , cord-010119-t1x9gknd 10259 9 but but CC cord-010119-t1x9gknd 10259 10 participated participate VBD cord-010119-t1x9gknd 10259 11 regularly regularly RB cord-010119-t1x9gknd 10259 12 in in IN cord-010119-t1x9gknd 10259 13 outdoor outdoor JJ cord-010119-t1x9gknd 10259 14 activities activity NNS cord-010119-t1x9gknd 10259 15 in in IN cord-010119-t1x9gknd 10259 16 Connecticut Connecticut NNP cord-010119-t1x9gknd 10259 17 that that WDT cord-010119-t1x9gknd 10259 18 put put VBD cord-010119-t1x9gknd 10259 19 him -PRON- PRP cord-010119-t1x9gknd 10259 20 at at IN cord-010119-t1x9gknd 10259 21 risk risk NN cord-010119-t1x9gknd 10259 22 for for IN cord-010119-t1x9gknd 10259 23 tick tick NN cord-010119-t1x9gknd 10259 24 bites bite NNS cord-010119-t1x9gknd 10259 25 ( ( -LRB- cord-010119-t1x9gknd 10259 26 although although IN cord-010119-t1x9gknd 10259 27 he -PRON- PRP cord-010119-t1x9gknd 10259 28 never never RB cord-010119-t1x9gknd 10259 29 noticed notice VBD cord-010119-t1x9gknd 10259 30 being be VBG cord-010119-t1x9gknd 10259 31 bitten bite VBN cord-010119-t1x9gknd 10259 32 or or CC cord-010119-t1x9gknd 10259 33 showing show VBG cord-010119-t1x9gknd 10259 34 signs sign NNS cord-010119-t1x9gknd 10259 35 of of IN cord-010119-t1x9gknd 10259 36 it -PRON- PRP cord-010119-t1x9gknd 10259 37 ) ) -RRB- cord-010119-t1x9gknd 10259 38 . . . cord-010119-t1x9gknd 10260 1 Upon upon IN cord-010119-t1x9gknd 10260 2 testing testing NN cord-010119-t1x9gknd 10260 3 , , , cord-010119-t1x9gknd 10260 4 he -PRON- PRP cord-010119-t1x9gknd 10260 5 was be VBD cord-010119-t1x9gknd 10260 6 found find VBN cord-010119-t1x9gknd 10260 7 to to TO cord-010119-t1x9gknd 10260 8 be be VB cord-010119-t1x9gknd 10260 9 negative negative JJ cord-010119-t1x9gknd 10260 10 for for IN cord-010119-t1x9gknd 10260 11 B. B. NNP cord-010119-t1x9gknd 10260 12 microti microti NN cord-010119-t1x9gknd 10260 13 on on IN cord-010119-t1x9gknd 10260 14 PCR PCR NNP cord-010119-t1x9gknd 10260 15 as as RB cord-010119-t1x9gknd 10260 16 well well RB cord-010119-t1x9gknd 10260 17 as as IN cord-010119-t1x9gknd 10260 18 IgM IgM NNP cord-010119-t1x9gknd 10260 19 antibodies antibody NNS cord-010119-t1x9gknd 10260 20 , , , cord-010119-t1x9gknd 10260 21 but but CC cord-010119-t1x9gknd 10260 22 had have VBD cord-010119-t1x9gknd 10260 23 IgG igg NN cord-010119-t1x9gknd 10260 24 antibody antibody NN cord-010119-t1x9gknd 10260 25 titers titer NNS cord-010119-t1x9gknd 10260 26 of of IN cord-010119-t1x9gknd 10260 27 1:256 1:256 CD cord-010119-t1x9gknd 10260 28 . . . cord-010119-t1x9gknd 10261 1 The the DT cord-010119-t1x9gknd 10261 2 recipient recipient NN cord-010119-t1x9gknd 10261 3 of of IN cord-010119-t1x9gknd 10261 4 the the DT cord-010119-t1x9gknd 10261 5 other other JJ cord-010119-t1x9gknd 10261 6 RBC RBC NNP cord-010119-t1x9gknd 10261 7 unit unit NN cord-010119-t1x9gknd 10261 8 collected collect VBN cord-010119-t1x9gknd 10261 9 in in IN cord-010119-t1x9gknd 10261 10 the the DT cord-010119-t1x9gknd 10261 11 same same JJ cord-010119-t1x9gknd 10261 12 donation donation NN cord-010119-t1x9gknd 10261 13 was be VBD cord-010119-t1x9gknd 10261 14 deceased decease VBN cord-010119-t1x9gknd 10261 15 within within IN cord-010119-t1x9gknd 10261 16 hours hour NNS cord-010119-t1x9gknd 10261 17 of of IN cord-010119-t1x9gknd 10261 18 transfusion transfusion NN cord-010119-t1x9gknd 10261 19 , , , cord-010119-t1x9gknd 10261 20 so so CC cord-010119-t1x9gknd 10261 21 no no DT cord-010119-t1x9gknd 10261 22 follow follow NN cord-010119-t1x9gknd 10261 23 up up RP cord-010119-t1x9gknd 10261 24 could could MD cord-010119-t1x9gknd 10261 25 be be VB cord-010119-t1x9gknd 10261 26 performed perform VBN cord-010119-t1x9gknd 10261 27 . . . cord-010119-t1x9gknd 10262 1 During during IN cord-010119-t1x9gknd 10262 2 phone phone NN cord-010119-t1x9gknd 10262 3 interviews interview NNS cord-010119-t1x9gknd 10262 4 , , , cord-010119-t1x9gknd 10262 5 none none NN cord-010119-t1x9gknd 10262 6 of of IN cord-010119-t1x9gknd 10262 7 the the DT cord-010119-t1x9gknd 10262 8 remaining remain VBG cord-010119-t1x9gknd 10262 9 donors donor NNS cord-010119-t1x9gknd 10262 10 had have VBD cord-010119-t1x9gknd 10262 11 risk risk NN cord-010119-t1x9gknd 10262 12 factors factor NNS cord-010119-t1x9gknd 10262 13 for for IN cord-010119-t1x9gknd 10262 14 babesiosis babesiosis NN cord-010119-t1x9gknd 10262 15 , , , cord-010119-t1x9gknd 10262 16 and and CC cord-010119-t1x9gknd 10262 17 all all DT cord-010119-t1x9gknd 10262 18 but but IN cord-010119-t1x9gknd 10262 19 four four CD cord-010119-t1x9gknd 10262 20 were be VBD cord-010119-t1x9gknd 10262 21 tested test VBN cord-010119-t1x9gknd 10262 22 and and CC cord-010119-t1x9gknd 10262 23 found find VBN cord-010119-t1x9gknd 10262 24 serologically serologically RB cord-010119-t1x9gknd 10262 25 negative negative JJ cord-010119-t1x9gknd 10262 26 . . . cord-010119-t1x9gknd 10263 1 Conclusion conclusion NN cord-010119-t1x9gknd 10263 2 : : : cord-010119-t1x9gknd 10263 3 While while IN cord-010119-t1x9gknd 10263 4 transmission transmission NN cord-010119-t1x9gknd 10263 5 of of IN cord-010119-t1x9gknd 10263 6 babesiosis babesiosis NN cord-010119-t1x9gknd 10263 7 through through IN cord-010119-t1x9gknd 10263 8 the the DT cord-010119-t1x9gknd 10263 9 zoonotic zoonotic JJ cord-010119-t1x9gknd 10263 10 route route NN cord-010119-t1x9gknd 10263 11 is be VBZ cord-010119-t1x9gknd 10263 12 confined confine VBN cord-010119-t1x9gknd 10263 13 to to IN cord-010119-t1x9gknd 10263 14 regions region NNS cord-010119-t1x9gknd 10263 15 were be VBD cord-010119-t1x9gknd 10263 16 the the DT cord-010119-t1x9gknd 10263 17 appropriate appropriate JJ cord-010119-t1x9gknd 10263 18 hosts host NNS cord-010119-t1x9gknd 10263 19 and and CC cord-010119-t1x9gknd 10263 20 vector vector NN cord-010119-t1x9gknd 10263 21 coexist coexist RB cord-010119-t1x9gknd 10263 22 , , , cord-010119-t1x9gknd 10263 23 people people NNS cord-010119-t1x9gknd 10263 24 from from IN cord-010119-t1x9gknd 10263 25 areas area NNS cord-010119-t1x9gknd 10263 26 where where WRB cord-010119-t1x9gknd 10263 27 it -PRON- PRP cord-010119-t1x9gknd 10263 28 is be VBZ cord-010119-t1x9gknd 10263 29 endemic endemic JJ cord-010119-t1x9gknd 10263 30 may may MD cord-010119-t1x9gknd 10263 31 establish establish VB cord-010119-t1x9gknd 10263 32 temporary temporary JJ cord-010119-t1x9gknd 10263 33 residency residency NN cord-010119-t1x9gknd 10263 34 and and CC cord-010119-t1x9gknd 10263 35 donate donate VB cord-010119-t1x9gknd 10263 36 blood blood NN cord-010119-t1x9gknd 10263 37 in in IN cord-010119-t1x9gknd 10263 38 non non JJ cord-010119-t1x9gknd 10263 39 - - JJ cord-010119-t1x9gknd 10263 40 endemic endemic JJ cord-010119-t1x9gknd 10263 41 locations location NNS cord-010119-t1x9gknd 10263 42 facilitating facilitate VBG cord-010119-t1x9gknd 10263 43 transmission transmission NN cord-010119-t1x9gknd 10263 44 through through IN cord-010119-t1x9gknd 10263 45 transfusion transfusion NN cord-010119-t1x9gknd 10263 46 as as IN cord-010119-t1x9gknd 10263 47 illustrated illustrate VBN cord-010119-t1x9gknd 10263 48 in in IN cord-010119-t1x9gknd 10263 49 this this DT cord-010119-t1x9gknd 10263 50 case case NN cord-010119-t1x9gknd 10263 51 . . . cord-010119-t1x9gknd 10264 1 Once once IN cord-010119-t1x9gknd 10264 2 licensed license VBN cord-010119-t1x9gknd 10264 3 assays assay NNS cord-010119-t1x9gknd 10264 4 for for IN cord-010119-t1x9gknd 10264 5 Babesia Babesia NNP cord-010119-t1x9gknd 10264 6 microti microti NN cord-010119-t1x9gknd 10264 7 become become VBP cord-010119-t1x9gknd 10264 8 available available JJ cord-010119-t1x9gknd 10264 9 , , , cord-010119-t1x9gknd 10264 10 testing testing NN cord-010119-t1x9gknd 10264 11 schemes scheme NNS cord-010119-t1x9gknd 10264 12 will will MD cord-010119-t1x9gknd 10264 13 have have VB cord-010119-t1x9gknd 10264 14 to to TO cord-010119-t1x9gknd 10264 15 be be VB cord-010119-t1x9gknd 10264 16 formulated formulate VBN cord-010119-t1x9gknd 10264 17 through through IN cord-010119-t1x9gknd 10264 18 policies policy NNS cord-010119-t1x9gknd 10264 19 that that WDT cord-010119-t1x9gknd 10264 20 take take VBP cord-010119-t1x9gknd 10264 21 this this DT cord-010119-t1x9gknd 10264 22 issue issue NN cord-010119-t1x9gknd 10264 23 into into IN cord-010119-t1x9gknd 10264 24 consideration consideration NN cord-010119-t1x9gknd 10264 25 . . . cord-010119-t1x9gknd 10265 1 Transfusion transfusion NN cord-010119-t1x9gknd 10265 2 - - HYPH cord-010119-t1x9gknd 10265 3 Transmitted transmit VBN cord-010119-t1x9gknd 10265 4 Stenotrophomonas Stenotrophomonas NNP cord-010119-t1x9gknd 10265 5 Maltophilia Maltophilia NNP cord-010119-t1x9gknd 10265 6 from from IN cord-010119-t1x9gknd 10265 7 a a DT cord-010119-t1x9gknd 10265 8 Red Red NNP cord-010119-t1x9gknd 10265 9 Cell Cell NNP cord-010119-t1x9gknd 10265 10 Unit Unit NNP cord-010119-t1x9gknd 10265 11 : : : cord-010119-t1x9gknd 10266 1 A a DT cord-010119-t1x9gknd 10266 2 Case Case NNP cord-010119-t1x9gknd 10266 3 Report report NN cord-010119-t1x9gknd 10266 4 Ashley Ashley NNP cord-010119-t1x9gknd 10266 5 C c NN cord-010119-t1x9gknd 10266 6 Gamayo Gamayo NNP cord-010119-t1x9gknd 10267 1 * * NFP cord-010119-t1x9gknd 10267 2 1 1 CD cord-010119-t1x9gknd 10267 3 , , , cord-010119-t1x9gknd 10267 4 Andrea Andrea NNP cord-010119-t1x9gknd 10267 5 J J NNP cord-010119-t1x9gknd 10267 6 Linscott Linscott NNP cord-010119-t1x9gknd 10267 7 2 2 CD cord-010119-t1x9gknd 10267 8 and and CC cord-010119-t1x9gknd 10267 9 Donny Donny NNP cord-010119-t1x9gknd 10267 10 Dumani Dumani NNP cord-010119-t1x9gknd 10267 11 3 3 CD cord-010119-t1x9gknd 10267 12 . . . cord-010119-t1x9gknd 10268 1 Background Background NNP cord-010119-t1x9gknd 10268 2 / / SYM cord-010119-t1x9gknd 10268 3 Case Case NNP cord-010119-t1x9gknd 10268 4 Studies Studies NNPS cord-010119-t1x9gknd 10268 5 : : : cord-010119-t1x9gknd 10268 6 Transfusion transfusion NN cord-010119-t1x9gknd 10268 7 - - HYPH cord-010119-t1x9gknd 10268 8 transmitted transmit VBN cord-010119-t1x9gknd 10268 9 bacterial bacterial JJ cord-010119-t1x9gknd 10268 10 infections infection NNS cord-010119-t1x9gknd 10268 11 ( ( -LRB- cord-010119-t1x9gknd 10268 12 TTBI TTBI NNP cord-010119-t1x9gknd 10268 13 ) ) -RRB- cord-010119-t1x9gknd 10268 14 are be VBP cord-010119-t1x9gknd 10268 15 rare rare JJ cord-010119-t1x9gknd 10268 16 , , , cord-010119-t1x9gknd 10268 17 but but CC cord-010119-t1x9gknd 10268 18 serious serious JJ cord-010119-t1x9gknd 10268 19 complications complication NNS cord-010119-t1x9gknd 10268 20 of of IN cord-010119-t1x9gknd 10268 21 blood blood NN cord-010119-t1x9gknd 10268 22 product product NN cord-010119-t1x9gknd 10268 23 transfusions transfusion NNS cord-010119-t1x9gknd 10268 24 . . . cord-010119-t1x9gknd 10269 1 From from IN cord-010119-t1x9gknd 10269 2 2011 2011 CD cord-010119-t1x9gknd 10269 3 - - SYM cord-010119-t1x9gknd 10269 4 2015 2015 CD cord-010119-t1x9gknd 10269 5 , , , cord-010119-t1x9gknd 10269 6 8 8 CD cord-010119-t1x9gknd 10269 7 % % NN cord-010119-t1x9gknd 10269 8 of of IN cord-010119-t1x9gknd 10269 9 173 173 CD cord-010119-t1x9gknd 10269 10 transfusion transfusion NN cord-010119-t1x9gknd 10269 11 - - HYPH cord-010119-t1x9gknd 10269 12 associated associate VBN cord-010119-t1x9gknd 10269 13 fatalities fatality NNS cord-010119-t1x9gknd 10269 14 reported report VBD cord-010119-t1x9gknd 10269 15 to to IN cord-010119-t1x9gknd 10269 16 the the DT cord-010119-t1x9gknd 10269 17 FDA FDA NNP cord-010119-t1x9gknd 10269 18 were be VBD cord-010119-t1x9gknd 10269 19 attributed attribute VBN cord-010119-t1x9gknd 10269 20 to to IN cord-010119-t1x9gknd 10269 21 bacterial bacterial JJ cord-010119-t1x9gknd 10269 22 contamination contamination NN cord-010119-t1x9gknd 10269 23 . . . cord-010119-t1x9gknd 10270 1 Red red JJ cord-010119-t1x9gknd 10270 2 cell cell NN cord-010119-t1x9gknd 10270 3 units unit NNS cord-010119-t1x9gknd 10270 4 are be VBP cord-010119-t1x9gknd 10270 5 rarely rarely RB cord-010119-t1x9gknd 10270 6 implicated implicate VBN cord-010119-t1x9gknd 10270 7 in in IN cord-010119-t1x9gknd 10270 8 severe severe JJ cord-010119-t1x9gknd 10270 9 and and CC cord-010119-t1x9gknd 10270 10 fatal fatal JJ cord-010119-t1x9gknd 10270 11 TTBI ttbi NN cord-010119-t1x9gknd 10270 12 . . . cord-010119-t1x9gknd 10271 1 When when WRB cord-010119-t1x9gknd 10271 2 present present JJ cord-010119-t1x9gknd 10271 3 , , , cord-010119-t1x9gknd 10271 4 contaminants contaminant NNS cord-010119-t1x9gknd 10271 5 are be VBP cord-010119-t1x9gknd 10271 6 often often RB cord-010119-t1x9gknd 10271 7 gram gram JJ cord-010119-t1x9gknd 10271 8 - - HYPH cord-010119-t1x9gknd 10271 9 negative negative JJ cord-010119-t1x9gknd 10271 10 rod rod NN cord-010119-t1x9gknd 10271 11 ( ( -LRB- cord-010119-t1x9gknd 10271 12 GNR GNR NNP cord-010119-t1x9gknd 10271 13 ) ) -RRB- cord-010119-t1x9gknd 10271 14 bacteria bacteria NNS cord-010119-t1x9gknd 10271 15 with with IN cord-010119-t1x9gknd 10271 16 psychrophilic psychrophilic NN cord-010119-t1x9gknd 10271 17 properties property NNS cord-010119-t1x9gknd 10271 18 . . . cord-010119-t1x9gknd 10272 1 We -PRON- PRP cord-010119-t1x9gknd 10272 2 present present VBP cord-010119-t1x9gknd 10272 3 a a DT cord-010119-t1x9gknd 10272 4 case case NN cord-010119-t1x9gknd 10272 5 of of IN cord-010119-t1x9gknd 10272 6 a a DT cord-010119-t1x9gknd 10272 7 sickle sickle NN cord-010119-t1x9gknd 10272 8 cell cell NN cord-010119-t1x9gknd 10272 9 patient patient NN cord-010119-t1x9gknd 10272 10 who who WP cord-010119-t1x9gknd 10272 11 developed develop VBD cord-010119-t1x9gknd 10272 12 definitive definitive JJ cord-010119-t1x9gknd 10272 13 sepsis sepsis NN cord-010119-t1x9gknd 10272 14 after after IN cord-010119-t1x9gknd 10272 15 receiving receive VBG cord-010119-t1x9gknd 10272 16 a a DT cord-010119-t1x9gknd 10272 17 red red JJ cord-010119-t1x9gknd 10272 18 cell cell NN cord-010119-t1x9gknd 10272 19 unit unit NN cord-010119-t1x9gknd 10272 20 contaminated contaminate VBN cord-010119-t1x9gknd 10272 21 with with IN cord-010119-t1x9gknd 10272 22 Stenotrophomonas Stenotrophomonas NNP cord-010119-t1x9gknd 10272 23 maltophilia maltophilia NNP cord-010119-t1x9gknd 10272 24 ( ( -LRB- cord-010119-t1x9gknd 10272 25 S. S. NNP cord-010119-t1x9gknd 10272 26 maltophilia maltophilia NNP cord-010119-t1x9gknd 10272 27 ) ) -RRB- cord-010119-t1x9gknd 10272 28 . . . cord-010119-t1x9gknd 10273 1 Study Study NNP cord-010119-t1x9gknd 10273 2 Design Design NNP cord-010119-t1x9gknd 10273 3 / / SYM cord-010119-t1x9gknd 10273 4 Methods method NNS cord-010119-t1x9gknd 10273 5 : : : cord-010119-t1x9gknd 10274 1 A a DT cord-010119-t1x9gknd 10274 2 27-year 27-year JJ cord-010119-t1x9gknd 10274 3 - - HYPH cord-010119-t1x9gknd 10274 4 old old JJ cord-010119-t1x9gknd 10274 5 female female NN cord-010119-t1x9gknd 10274 6 with with IN cord-010119-t1x9gknd 10274 7 sickle sickle NN cord-010119-t1x9gknd 10274 8 cell cell NN cord-010119-t1x9gknd 10274 9 disease disease NN cord-010119-t1x9gknd 10274 10 was be VBD cord-010119-t1x9gknd 10274 11 admitted admit VBN cord-010119-t1x9gknd 10274 12 to to IN cord-010119-t1x9gknd 10274 13 the the DT cord-010119-t1x9gknd 10274 14 hospital hospital NN cord-010119-t1x9gknd 10274 15 for for IN cord-010119-t1x9gknd 10274 16 possible possible JJ cord-010119-t1x9gknd 10274 17 pain pain NN cord-010119-t1x9gknd 10274 18 crises crisis NNS cord-010119-t1x9gknd 10274 19 . . . cord-010119-t1x9gknd 10275 1 Pre pre JJ cord-010119-t1x9gknd 10275 2 - - JJ cord-010119-t1x9gknd 10275 3 transfusion transfusion JJ cord-010119-t1x9gknd 10275 4 blood blood NN cord-010119-t1x9gknd 10275 5 and and CC cord-010119-t1x9gknd 10275 6 urine urine NN cord-010119-t1x9gknd 10275 7 cultures culture NNS cord-010119-t1x9gknd 10275 8 collected collect VBN cord-010119-t1x9gknd 10275 9 on on IN cord-010119-t1x9gknd 10275 10 Day day NN cord-010119-t1x9gknd 10275 11 1 1 CD cord-010119-t1x9gknd 10275 12 of of IN cord-010119-t1x9gknd 10275 13 hospitalization hospitalization NN cord-010119-t1x9gknd 10275 14 showed show VBD cord-010119-t1x9gknd 10275 15 no no DT cord-010119-t1x9gknd 10275 16 growth growth NN cord-010119-t1x9gknd 10275 17 after after IN cord-010119-t1x9gknd 10275 18 five five CD cord-010119-t1x9gknd 10275 19 days day NNS cord-010119-t1x9gknd 10275 20 . . . cord-010119-t1x9gknd 10276 1 On on IN cord-010119-t1x9gknd 10276 2 Day Day NNP cord-010119-t1x9gknd 10276 3 3 3 CD cord-010119-t1x9gknd 10276 4 , , , cord-010119-t1x9gknd 10276 5 the the DT cord-010119-t1x9gknd 10276 6 patient patient NN cord-010119-t1x9gknd 10276 7 required require VBD cord-010119-t1x9gknd 10276 8 a a DT cord-010119-t1x9gknd 10276 9 blood blood NN cord-010119-t1x9gknd 10276 10 transfusion transfusion NN cord-010119-t1x9gknd 10276 11 for for IN cord-010119-t1x9gknd 10276 12 which which WDT cord-010119-t1x9gknd 10276 13 she -PRON- PRP cord-010119-t1x9gknd 10276 14 was be VBD cord-010119-t1x9gknd 10276 15 issued issue VBN cord-010119-t1x9gknd 10276 16 a a DT cord-010119-t1x9gknd 10276 17 CMV CMV NNP cord-010119-t1x9gknd 10276 18 - - HYPH cord-010119-t1x9gknd 10276 19 safe safe JJ cord-010119-t1x9gknd 10276 20 , , , cord-010119-t1x9gknd 10276 21 irradiated irradiate VBN cord-010119-t1x9gknd 10276 22 , , , cord-010119-t1x9gknd 10276 23 HbS hbs JJ cord-010119-t1x9gknd 10276 24 - - HYPH cord-010119-t1x9gknd 10276 25 negative negative JJ cord-010119-t1x9gknd 10276 26 , , , cord-010119-t1x9gknd 10276 27 crossmatched crossmatched JJ cord-010119-t1x9gknd 10276 28 , , , cord-010119-t1x9gknd 10276 29 O o NN cord-010119-t1x9gknd 10276 30 - - HYPH cord-010119-t1x9gknd 10276 31 negative negative JJ cord-010119-t1x9gknd 10276 32 red red JJ cord-010119-t1x9gknd 10276 33 cell cell NN cord-010119-t1x9gknd 10276 34 unit unit NN cord-010119-t1x9gknd 10276 35 . . . cord-010119-t1x9gknd 10277 1 The the DT cord-010119-t1x9gknd 10277 2 318 318 CD cord-010119-t1x9gknd 10277 3 mL ml NN cord-010119-t1x9gknd 10277 4 unit unit NN cord-010119-t1x9gknd 10277 5 had have VBD cord-010119-t1x9gknd 10277 6 been be VBN cord-010119-t1x9gknd 10277 7 aliquoted aliquote VBN cord-010119-t1x9gknd 10277 8 via via IN cord-010119-t1x9gknd 10277 9 sterile sterile JJ cord-010119-t1x9gknd 10277 10 connecting connect VBG cord-010119-t1x9gknd 10277 11 device device NN cord-010119-t1x9gknd 10277 12 12 12 CD cord-010119-t1x9gknd 10277 13 days day NNS cord-010119-t1x9gknd 10277 14 prior prior RB cord-010119-t1x9gknd 10277 15 for for IN cord-010119-t1x9gknd 10277 16 a a DT cord-010119-t1x9gknd 10277 17 pediatric pediatric JJ cord-010119-t1x9gknd 10277 18 patient patient NN cord-010119-t1x9gknd 10277 19 . . . cord-010119-t1x9gknd 10278 1 All all DT cord-010119-t1x9gknd 10278 2 26 26 CD cord-010119-t1x9gknd 10278 3 mL ml NN cord-010119-t1x9gknd 10278 4 of of IN cord-010119-t1x9gknd 10278 5 the the DT cord-010119-t1x9gknd 10278 6 pediatric pediatric JJ cord-010119-t1x9gknd 10278 7 aliquot aliquot NN cord-010119-t1x9gknd 10278 8 were be VBD cord-010119-t1x9gknd 10278 9 transfused transfuse VBN cord-010119-t1x9gknd 10278 10 without without IN cord-010119-t1x9gknd 10278 11 adverse adverse JJ cord-010119-t1x9gknd 10278 12 effects effect NNS cord-010119-t1x9gknd 10278 13 . . . cord-010119-t1x9gknd 10279 1 The the DT cord-010119-t1x9gknd 10279 2 patient patient NN cord-010119-t1x9gknd 10279 3 's 's POS cord-010119-t1x9gknd 10279 4 pretransfusion pretransfusion NN cord-010119-t1x9gknd 10279 5 temperature temperature NN cord-010119-t1x9gknd 10279 6 was be VBD cord-010119-t1x9gknd 10279 7 37.18C. 37.18c. CD cord-010119-t1x9gknd 10279 8 Within within IN cord-010119-t1x9gknd 10279 9 45 45 CD cord-010119-t1x9gknd 10279 10 minutes minute NNS cord-010119-t1x9gknd 10279 11 of of IN cord-010119-t1x9gknd 10279 12 starting start VBG cord-010119-t1x9gknd 10279 13 the the DT cord-010119-t1x9gknd 10279 14 transfusion transfusion NN cord-010119-t1x9gknd 10279 15 , , , cord-010119-t1x9gknd 10279 16 the the DT cord-010119-t1x9gknd 10279 17 patient patient NN cord-010119-t1x9gknd 10279 18 's 's POS cord-010119-t1x9gknd 10279 19 temperature temperature NN cord-010119-t1x9gknd 10279 20 increased increase VBD cord-010119-t1x9gknd 10279 21 to to IN cord-010119-t1x9gknd 10279 22 39.38C 39.38c CD cord-010119-t1x9gknd 10279 23 and and CC cord-010119-t1x9gknd 10279 24 subsequently subsequently RB cord-010119-t1x9gknd 10279 25 reached reach VBD cord-010119-t1x9gknd 10279 26 a a DT cord-010119-t1x9gknd 10279 27 maximum maximum NN cord-010119-t1x9gknd 10279 28 of of IN cord-010119-t1x9gknd 10279 29 39.58C. 39.58c. CD cord-010119-t1x9gknd 10279 30 The the DT cord-010119-t1x9gknd 10279 31 transfusion transfusion NN cord-010119-t1x9gknd 10279 32 was be VBD cord-010119-t1x9gknd 10279 33 stopped stop VBN cord-010119-t1x9gknd 10279 34 and and CC cord-010119-t1x9gknd 10279 35 the the DT cord-010119-t1x9gknd 10279 36 blood blood NN cord-010119-t1x9gknd 10279 37 bank bank NN cord-010119-t1x9gknd 10279 38 notified notify VBN cord-010119-t1x9gknd 10279 39 immediately immediately RB cord-010119-t1x9gknd 10279 40 . . . cord-010119-t1x9gknd 10280 1 Gram gram NN cord-010119-t1x9gknd 10280 2 stain stain NN cord-010119-t1x9gknd 10280 3 of of IN cord-010119-t1x9gknd 10280 4 the the DT cord-010119-t1x9gknd 10280 5 remainder remainder NN cord-010119-t1x9gknd 10280 6 of of IN cord-010119-t1x9gknd 10280 7 the the DT cord-010119-t1x9gknd 10280 8 transfused transfuse VBN cord-010119-t1x9gknd 10280 9 component component NN cord-010119-t1x9gknd 10280 10 revealed reveal VBD cord-010119-t1x9gknd 10280 11 GNR GNR NNP cord-010119-t1x9gknd 10280 12 bacteria bacteria NNS cord-010119-t1x9gknd 10280 13 . . . cord-010119-t1x9gknd 10281 1 Blood blood NN cord-010119-t1x9gknd 10281 2 was be VBD cord-010119-t1x9gknd 10281 3 collected collect VBN cord-010119-t1x9gknd 10281 4 from from IN cord-010119-t1x9gknd 10281 5 the the DT cord-010119-t1x9gknd 10281 6 patient patient NN cord-010119-t1x9gknd 10281 7 for for IN cord-010119-t1x9gknd 10281 8 culture culture NN cord-010119-t1x9gknd 10281 9 and and CC cord-010119-t1x9gknd 10281 10 antibiotic antibiotic JJ cord-010119-t1x9gknd 10281 11 treatment treatment NN cord-010119-t1x9gknd 10281 12 initiated initiate VBN cord-010119-t1x9gknd 10281 13 . . . cord-010119-t1x9gknd 10282 1 Results result NNS cord-010119-t1x9gknd 10282 2 / / SYM cord-010119-t1x9gknd 10282 3 Findings finding NNS cord-010119-t1x9gknd 10282 4 : : : cord-010119-t1x9gknd 10283 1 Initial initial JJ cord-010119-t1x9gknd 10283 2 transfusion transfusion NN cord-010119-t1x9gknd 10283 3 reaction reaction NN cord-010119-t1x9gknd 10283 4 work work NN cord-010119-t1x9gknd 10283 5 - - HYPH cord-010119-t1x9gknd 10283 6 up up NN cord-010119-t1x9gknd 10283 7 revealed reveal VBD cord-010119-t1x9gknd 10283 8 no no DT cord-010119-t1x9gknd 10283 9 evidence evidence NN cord-010119-t1x9gknd 10283 10 of of IN cord-010119-t1x9gknd 10283 11 clerical clerical JJ cord-010119-t1x9gknd 10283 12 errors error NNS cord-010119-t1x9gknd 10283 13 with with IN cord-010119-t1x9gknd 10283 14 negative negative JJ cord-010119-t1x9gknd 10283 15 post post JJ cord-010119-t1x9gknd 10283 16 - - JJ cord-010119-t1x9gknd 10283 17 transfusion transfusion JJ cord-010119-t1x9gknd 10283 18 antibody antibody NN cord-010119-t1x9gknd 10283 19 screen screen NN cord-010119-t1x9gknd 10283 20 and and CC cord-010119-t1x9gknd 10283 21 direct direct JJ cord-010119-t1x9gknd 10283 22 antiglobulin antiglobulin NN cord-010119-t1x9gknd 10283 23 test test NN cord-010119-t1x9gknd 10283 24 . . . cord-010119-t1x9gknd 10284 1 Blood blood NN cord-010119-t1x9gknd 10284 2 cultures culture NNS cord-010119-t1x9gknd 10284 3 from from IN cord-010119-t1x9gknd 10284 4 both both CC cord-010119-t1x9gknd 10284 5 the the DT cord-010119-t1x9gknd 10284 6 patient patient JJ cord-010119-t1x9gknd 10284 7 post post JJ cord-010119-t1x9gknd 10284 8 - - JJ cord-010119-t1x9gknd 10284 9 transfusion transfusion NN cord-010119-t1x9gknd 10284 10 and and CC cord-010119-t1x9gknd 10284 11 the the DT cord-010119-t1x9gknd 10284 12 implicated implicate VBN cord-010119-t1x9gknd 10284 13 red red JJ cord-010119-t1x9gknd 10284 14 cell cell NN cord-010119-t1x9gknd 10284 15 unit unit NN cord-010119-t1x9gknd 10284 16 grew grow VBD cord-010119-t1x9gknd 10284 17 GNR GNR NNP cord-010119-t1x9gknd 10284 18 bacteria bacteria NNS cord-010119-t1x9gknd 10284 19 identified identify VBN cord-010119-t1x9gknd 10284 20 as as IN cord-010119-t1x9gknd 10284 21 S. S. NNP cord-010119-t1x9gknd 10284 22 maltophilia maltophilia NNP cord-010119-t1x9gknd 10284 23 . . . cord-010119-t1x9gknd 10285 1 Further further JJ cord-010119-t1x9gknd 10285 2 microbial microbial JJ cord-010119-t1x9gknd 10285 3 testing testing NN cord-010119-t1x9gknd 10285 4 revealed reveal VBD cord-010119-t1x9gknd 10285 5 the the DT cord-010119-t1x9gknd 10285 6 cultured cultured JJ cord-010119-t1x9gknd 10285 7 pathogen pathogen NN cord-010119-t1x9gknd 10285 8 was be VBD cord-010119-t1x9gknd 10285 9 able able JJ cord-010119-t1x9gknd 10285 10 to to TO cord-010119-t1x9gknd 10285 11 proliferate proliferate VB cord-010119-t1x9gknd 10285 12 at at IN cord-010119-t1x9gknd 10285 13 4 4 CD cord-010119-t1x9gknd 10285 14 - - HYPH cord-010119-t1x9gknd 10285 15 68C 68C NNS cord-010119-t1x9gknd 10285 16 ; ; : cord-010119-t1x9gknd 10285 17 a a DT cord-010119-t1x9gknd 10285 18 finding finding NN cord-010119-t1x9gknd 10285 19 not not RB cord-010119-t1x9gknd 10285 20 characteristically characteristically RB cord-010119-t1x9gknd 10285 21 observed observe VBN cord-010119-t1x9gknd 10285 22 in in IN cord-010119-t1x9gknd 10285 23 S. S. NNP cord-010119-t1x9gknd 10285 24 maltophilia maltophilia NNP cord-010119-t1x9gknd 10285 25 . . . cord-010119-t1x9gknd 10286 1 Conclusion conclusion NN cord-010119-t1x9gknd 10286 2 : : : cord-010119-t1x9gknd 10287 1 This this DT cord-010119-t1x9gknd 10287 2 is be VBZ cord-010119-t1x9gknd 10287 3 the the DT cord-010119-t1x9gknd 10287 4 first first JJ cord-010119-t1x9gknd 10287 5 definitive definitive JJ cord-010119-t1x9gknd 10287 6 case case NN cord-010119-t1x9gknd 10287 7 of of IN cord-010119-t1x9gknd 10287 8 TTBI TTBI NNP cord-010119-t1x9gknd 10287 9 with with IN cord-010119-t1x9gknd 10287 10 S. S. NNP cord-010119-t1x9gknd 10287 11 maltophilia maltophilia NNP cord-010119-t1x9gknd 10287 12 . . . cord-010119-t1x9gknd 10288 1 This this DT cord-010119-t1x9gknd 10288 2 bacterium bacterium NN cord-010119-t1x9gknd 10288 3 is be VBZ cord-010119-t1x9gknd 10288 4 a a DT cord-010119-t1x9gknd 10288 5 globally globally RB cord-010119-t1x9gknd 10288 6 emerging emerge VBG cord-010119-t1x9gknd 10288 7 GNR GNR NNP cord-010119-t1x9gknd 10288 8 that that WDT cord-010119-t1x9gknd 10288 9 is be VBZ cord-010119-t1x9gknd 10288 10 widely widely RB cord-010119-t1x9gknd 10288 11 spread spread VBN cord-010119-t1x9gknd 10288 12 in in IN cord-010119-t1x9gknd 10288 13 the the DT cord-010119-t1x9gknd 10288 14 environment environment NN cord-010119-t1x9gknd 10288 15 , , , cord-010119-t1x9gknd 10288 16 causing cause VBG cord-010119-t1x9gknd 10288 17 both both DT cord-010119-t1x9gknd 10288 18 community community NN cord-010119-t1x9gknd 10288 19 - - HYPH cord-010119-t1x9gknd 10288 20 acquired acquire VBN cord-010119-t1x9gknd 10288 21 and and CC cord-010119-t1x9gknd 10288 22 nosocomial nosocomial JJ cord-010119-t1x9gknd 10288 23 infections infection NNS cord-010119-t1x9gknd 10288 24 in in IN cord-010119-t1x9gknd 10288 25 immunocompromised immunocompromised JJ cord-010119-t1x9gknd 10288 26 and and CC cord-010119-t1x9gknd 10288 27 debilitated debilitated JJ cord-010119-t1x9gknd 10288 28 patients patient NNS cord-010119-t1x9gknd 10288 29 . . . cord-010119-t1x9gknd 10289 1 Contamination contamination NN cord-010119-t1x9gknd 10289 2 was be VBD cord-010119-t1x9gknd 10289 3 unlikely unlikely JJ cord-010119-t1x9gknd 10289 4 due due IN cord-010119-t1x9gknd 10289 5 to to IN cord-010119-t1x9gknd 10289 6 an an DT cord-010119-t1x9gknd 10289 7 asymptomatic asymptomatic JJ cord-010119-t1x9gknd 10289 8 donor donor NN cord-010119-t1x9gknd 10289 9 . . . cord-010119-t1x9gknd 10290 1 There there EX cord-010119-t1x9gknd 10290 2 was be VBD cord-010119-t1x9gknd 10290 3 laboratory laboratory JJ cord-010119-t1x9gknd 10290 4 evidence evidence NN cord-010119-t1x9gknd 10290 5 of of IN cord-010119-t1x9gknd 10290 6 the the DT cord-010119-t1x9gknd 10290 7 pathogen pathogen NN cord-010119-t1x9gknd 10290 8 in in IN cord-010119-t1x9gknd 10290 9 both both CC cord-010119-t1x9gknd 10290 10 the the DT cord-010119-t1x9gknd 10290 11 transfusion transfusion NN cord-010119-t1x9gknd 10290 12 recipient recipient NN cord-010119-t1x9gknd 10290 13 and and CC cord-010119-t1x9gknd 10290 14 the the DT cord-010119-t1x9gknd 10290 15 transfused transfuse VBN cord-010119-t1x9gknd 10290 16 component component NN cord-010119-t1x9gknd 10290 17 . . . cord-010119-t1x9gknd 10291 1 The the DT cord-010119-t1x9gknd 10291 2 patient patient NN cord-010119-t1x9gknd 10291 3 was be VBD cord-010119-t1x9gknd 10291 4 not not RB cord-010119-t1x9gknd 10291 5 infected infect VBN cord-010119-t1x9gknd 10291 6 with with IN cord-010119-t1x9gknd 10291 7 the the DT cord-010119-t1x9gknd 10291 8 pathogen pathogen NN cord-010119-t1x9gknd 10291 9 prior prior RB cord-010119-t1x9gknd 10291 10 to to IN cord-010119-t1x9gknd 10291 11 transfusion transfusion NN cord-010119-t1x9gknd 10291 12 , , , cord-010119-t1x9gknd 10291 13 and and CC cord-010119-t1x9gknd 10291 14 no no DT cord-010119-t1x9gknd 10291 15 other other JJ cord-010119-t1x9gknd 10291 16 potential potential JJ cord-010119-t1x9gknd 10291 17 exposures exposure NNS cord-010119-t1x9gknd 10291 18 could could MD cord-010119-t1x9gknd 10291 19 be be VB cord-010119-t1x9gknd 10291 20 identified identify VBN cord-010119-t1x9gknd 10291 21 . . . cord-010119-t1x9gknd 10292 1 The the DT cord-010119-t1x9gknd 10292 2 patient patient NN cord-010119-t1x9gknd 10292 3 recovered recover VBD cord-010119-t1x9gknd 10292 4 following follow VBG cord-010119-t1x9gknd 10292 5 appropriate appropriate JJ cord-010119-t1x9gknd 10292 6 antibiotic antibiotic JJ cord-010119-t1x9gknd 10292 7 treatment treatment NN cord-010119-t1x9gknd 10292 8 , , , cord-010119-t1x9gknd 10292 9 but but CC cord-010119-t1x9gknd 10292 10 endured endure VBD cord-010119-t1x9gknd 10292 11 prolonged prolonged JJ cord-010119-t1x9gknd 10292 12 hospitalization hospitalization NN cord-010119-t1x9gknd 10292 13 . . . cord-010119-t1x9gknd 10293 1 The the DT cord-010119-t1x9gknd 10293 2 transfusion transfusion NN cord-010119-t1x9gknd 10293 3 reaction reaction NN cord-010119-t1x9gknd 10293 4 was be VBD cord-010119-t1x9gknd 10293 5 classified classify VBN cord-010119-t1x9gknd 10293 6 as as IN cord-010119-t1x9gknd 10293 7 definitive definitive JJ cord-010119-t1x9gknd 10293 8 , , , cord-010119-t1x9gknd 10293 9 severe severe JJ cord-010119-t1x9gknd 10293 10 TTI TTI NNP cord-010119-t1x9gknd 10293 11 of of IN cord-010119-t1x9gknd 10293 12 definite definite JJ cord-010119-t1x9gknd 10293 13 imputability imputability NN cord-010119-t1x9gknd 10293 14 . . . cord-010119-t1x9gknd 10294 1 Validation validation NN cord-010119-t1x9gknd 10294 2 of of IN cord-010119-t1x9gknd 10294 3 Commercial Commercial NNP cord-010119-t1x9gknd 10294 4 Immunoassays Immunoassays NNPS cord-010119-t1x9gknd 10294 5 for for IN cord-010119-t1x9gknd 10294 6 Detecting detect VBG cord-010119-t1x9gknd 10294 7 HBsAg hbsag ADD cord-010119-t1x9gknd 10294 8 and and CC cord-010119-t1x9gknd 10294 9 HIV HIV NNP cord-010119-t1x9gknd 10294 10 Antibodies Antibodies NNP cord-010119-t1x9gknd 10294 11 in in IN cord-010119-t1x9gknd 10294 12 Production Production NNP cord-010119-t1x9gknd 10294 13 Pools Pools NNP cord-010119-t1x9gknd 10294 14 Karen Karen NNP cord-010119-t1x9gknd 10294 15 Leighton Leighton NNP cord-010119-t1x9gknd 10294 16 , , , cord-010119-t1x9gknd 10294 17 Izekial Izekial NNP cord-010119-t1x9gknd 10294 18 Butler Butler NNP cord-010119-t1x9gknd 10294 19 and and CC cord-010119-t1x9gknd 10294 20 Scott Scott NNP cord-010119-t1x9gknd 10294 21 Jones Jones NNP cord-010119-t1x9gknd 10295 1 * * NFP cord-010119-t1x9gknd 10295 2 . . . cord-010119-t1x9gknd 10296 1 QualTex QualTex NNP cord-010119-t1x9gknd 10296 2 Laboratories Laboratories NNPS cord-010119-t1x9gknd 10296 3 Background Background NNP cord-010119-t1x9gknd 10296 4 / / SYM cord-010119-t1x9gknd 10296 5 Case Case NNP cord-010119-t1x9gknd 10296 6 Studies Studies NNPS cord-010119-t1x9gknd 10296 7 : : : cord-010119-t1x9gknd 10297 1 Plasma plasma NN cord-010119-t1x9gknd 10297 2 fractionators fractionator NNS cord-010119-t1x9gknd 10297 3 test test NN cord-010119-t1x9gknd 10297 4 plasma plasma NN cord-010119-t1x9gknd 10297 5 production production NN cord-010119-t1x9gknd 10297 6 pools pool NNS cord-010119-t1x9gknd 10297 7 for for IN cord-010119-t1x9gknd 10297 8 HBsAg HBsAg NNP cord-010119-t1x9gknd 10297 9 and and CC cord-010119-t1x9gknd 10297 10 HIV HIV NNP cord-010119-t1x9gknd 10297 11 antibodies antibody NNS cord-010119-t1x9gknd 10297 12 as as IN cord-010119-t1x9gknd 10297 13 a a DT cord-010119-t1x9gknd 10297 14 qualitative qualitative JJ cord-010119-t1x9gknd 10297 15 limit limit NN cord-010119-t1x9gknd 10297 16 test test NN cord-010119-t1x9gknd 10297 17 for for IN cord-010119-t1x9gknd 10297 18 the the DT cord-010119-t1x9gknd 10297 19 control control NN cord-010119-t1x9gknd 10297 20 of of IN cord-010119-t1x9gknd 10297 21 impurities impurity NNS cord-010119-t1x9gknd 10297 22 , , , cord-010119-t1x9gknd 10297 23 to to TO cord-010119-t1x9gknd 10297 24 safeguard safeguard VB cord-010119-t1x9gknd 10297 25 against against IN cord-010119-t1x9gknd 10297 26 errors error NNS cord-010119-t1x9gknd 10297 27 in in IN cord-010119-t1x9gknd 10297 28 donation donation NN cord-010119-t1x9gknd 10297 29 testing testing NN cord-010119-t1x9gknd 10297 30 or or CC cord-010119-t1x9gknd 10297 31 pooling pooling NN cord-010119-t1x9gknd 10297 32 . . . cord-010119-t1x9gknd 10298 1 The the DT cord-010119-t1x9gknd 10298 2 European European NNP cord-010119-t1x9gknd 10298 3 Medicines Medicines NNP cord-010119-t1x9gknd 10298 4 agency agency NN cord-010119-t1x9gknd 10298 5 ( ( -LRB- cord-010119-t1x9gknd 10298 6 EMA EMA NNP cord-010119-t1x9gknd 10298 7 ) ) -RRB- cord-010119-t1x9gknd 10298 8 has have VBZ cord-010119-t1x9gknd 10298 9 published publish VBN cord-010119-t1x9gknd 10298 10 guidelines guideline NNS cord-010119-t1x9gknd 10298 11 for for IN cord-010119-t1x9gknd 10298 12 the the DT cord-010119-t1x9gknd 10298 13 validation validation NN cord-010119-t1x9gknd 10298 14 of of IN cord-010119-t1x9gknd 10298 15 immunoassays immunoassays NNP cord-010119-t1x9gknd 10298 16 for for IN cord-010119-t1x9gknd 10298 17 the the DT cord-010119-t1x9gknd 10298 18 detection detection NN cord-010119-t1x9gknd 10298 19 of of IN cord-010119-t1x9gknd 10298 20 HBsAg HBsAg NNP cord-010119-t1x9gknd 10298 21 and and CC cord-010119-t1x9gknd 10298 22 HIV HIV NNP cord-010119-t1x9gknd 10298 23 antibodies antibody NNS cord-010119-t1x9gknd 10298 24 in in IN cord-010119-t1x9gknd 10298 25 production production NN cord-010119-t1x9gknd 10298 26 pools pool NNS cord-010119-t1x9gknd 10298 27 . . . cord-010119-t1x9gknd 10299 1 The the DT cord-010119-t1x9gknd 10299 2 aim aim NN cord-010119-t1x9gknd 10299 3 was be VBD cord-010119-t1x9gknd 10299 4 to to TO cord-010119-t1x9gknd 10299 5 validate validate VB cord-010119-t1x9gknd 10299 6 commercial commercial JJ cord-010119-t1x9gknd 10299 7 immunoassays immunoassay NNS cord-010119-t1x9gknd 10299 8 for for IN cord-010119-t1x9gknd 10299 9 the the DT cord-010119-t1x9gknd 10299 10 testing testing NN cord-010119-t1x9gknd 10299 11 of of IN cord-010119-t1x9gknd 10299 12 production production NN cord-010119-t1x9gknd 10299 13 pools pool NNS cord-010119-t1x9gknd 10299 14 for for IN cord-010119-t1x9gknd 10299 15 HBsAg HBsAg NNP cord-010119-t1x9gknd 10299 16 and and CC cord-010119-t1x9gknd 10299 17 HIV HIV NNP cord-010119-t1x9gknd 10299 18 antibodies antibody NNS cord-010119-t1x9gknd 10299 19 utilizing utilize VBG cord-010119-t1x9gknd 10299 20 the the DT cord-010119-t1x9gknd 10299 21 EMA EMA NNP cord-010119-t1x9gknd 10299 22 guidelines guideline NNS cord-010119-t1x9gknd 10299 23 . . . cord-010119-t1x9gknd 10300 1 Study Study NNP cord-010119-t1x9gknd 10300 2 Design Design NNP cord-010119-t1x9gknd 10300 3 / / SYM cord-010119-t1x9gknd 10300 4 Method method NN cord-010119-t1x9gknd 10300 5 : : : cord-010119-t1x9gknd 10301 1 A a DT cord-010119-t1x9gknd 10301 2 lower lower RBR cord-010119-t1x9gknd 10301 3 calculated calculate VBN cord-010119-t1x9gknd 10301 4 cutoff cutoff NN cord-010119-t1x9gknd 10301 5 value value NN cord-010119-t1x9gknd 10301 6 for for IN cord-010119-t1x9gknd 10301 7 the the DT cord-010119-t1x9gknd 10301 8 ABBOTT ABBOTT NNP cord-010119-t1x9gknd 10301 9 PRISM PRISM NNP cord-010119-t1x9gknd 10301 10 HBsAg hbsag ADD cord-010119-t1x9gknd 10301 11 and and CC cord-010119-t1x9gknd 10301 12 HIV HIV NNP cord-010119-t1x9gknd 10301 13 O O NNP cord-010119-t1x9gknd 10301 14 Plus Plus NNP cord-010119-t1x9gknd 10301 15 assays assay NNS cord-010119-t1x9gknd 10301 16 was be VBD cord-010119-t1x9gknd 10301 17 determined determine VBN cord-010119-t1x9gknd 10301 18 by by IN cord-010119-t1x9gknd 10301 19 calculating calculate VBG cord-010119-t1x9gknd 10301 20 the the DT cord-010119-t1x9gknd 10301 21 mean mean JJ cord-010119-t1x9gknd 10301 22 signal signal NN cord-010119-t1x9gknd 10301 23 - - HYPH cord-010119-t1x9gknd 10301 24 to to IN cord-010119-t1x9gknd 10301 25 - - HYPH cord-010119-t1x9gknd 10301 26 cutoff cutoff NN cord-010119-t1x9gknd 10301 27 ratio ratio NN cord-010119-t1x9gknd 10301 28 ( ( -LRB- cord-010119-t1x9gknd 10301 29 S S NNP cord-010119-t1x9gknd 10301 30 / / SYM cord-010119-t1x9gknd 10301 31 CO CO NNP cord-010119-t1x9gknd 10301 32 ) ) -RRB- cord-010119-t1x9gknd 10301 33 plus plus CC cord-010119-t1x9gknd 10301 34 3 3 CD cord-010119-t1x9gknd 10301 35 standard standard JJ cord-010119-t1x9gknd 10301 36 deviations deviation NNS cord-010119-t1x9gknd 10301 37 of of IN cord-010119-t1x9gknd 10301 38 four four CD cord-010119-t1x9gknd 10301 39 different different JJ cord-010119-t1x9gknd 10301 40 types type NNS cord-010119-t1x9gknd 10301 41 of of IN cord-010119-t1x9gknd 10301 42 plasma plasma NN cord-010119-t1x9gknd 10301 43 production production NN cord-010119-t1x9gknd 10301 44 pool pool NN cord-010119-t1x9gknd 10301 45 samples sample NNS cord-010119-t1x9gknd 10301 46 . . . cord-010119-t1x9gknd 10302 1 The the DT cord-010119-t1x9gknd 10302 2 calculated calculate VBN cord-010119-t1x9gknd 10302 3 cutoff cutoff NN cord-010119-t1x9gknd 10302 4 values value NNS cord-010119-t1x9gknd 10302 5 were be VBD cord-010119-t1x9gknd 10302 6 utilized utilize VBN cord-010119-t1x9gknd 10302 7 for for IN cord-010119-t1x9gknd 10302 8 the the DT cord-010119-t1x9gknd 10302 9 rest rest NN cord-010119-t1x9gknd 10302 10 of of IN cord-010119-t1x9gknd 10302 11 the the DT cord-010119-t1x9gknd 10302 12 validation validation NN cord-010119-t1x9gknd 10302 13 . . . cord-010119-t1x9gknd 10303 1 The the DT cord-010119-t1x9gknd 10303 2 detection detection NN cord-010119-t1x9gknd 10303 3 limit limit NN cord-010119-t1x9gknd 10303 4 was be VBD cord-010119-t1x9gknd 10303 5 determined determine VBN cord-010119-t1x9gknd 10303 6 by by IN cord-010119-t1x9gknd 10303 7 testing test VBG cord-010119-t1x9gknd 10303 8 in in IN cord-010119-t1x9gknd 10303 9 triplicate triplicate NN cord-010119-t1x9gknd 10303 10 , , , cord-010119-t1x9gknd 10303 11 serial serial JJ cord-010119-t1x9gknd 10303 12 dilutions dilution NNS cord-010119-t1x9gknd 10303 13 of of IN cord-010119-t1x9gknd 10303 14 WHO who WP cord-010119-t1x9gknd 10303 15 HBsAg hbsag ADD cord-010119-t1x9gknd 10303 16 and and CC cord-010119-t1x9gknd 10303 17 HIV HIV NNP cord-010119-t1x9gknd 10303 18 antibody antibody NN cord-010119-t1x9gknd 10303 19 standards standard NNS cord-010119-t1x9gknd 10303 20 diluted dilute VBN cord-010119-t1x9gknd 10303 21 in in IN cord-010119-t1x9gknd 10303 22 plasma plasma NN cord-010119-t1x9gknd 10303 23 . . . cord-010119-t1x9gknd 10304 1 A a DT cord-010119-t1x9gknd 10304 2 normalized normalized JJ cord-010119-t1x9gknd 10304 3 detection detection NN cord-010119-t1x9gknd 10304 4 limit limit NN cord-010119-t1x9gknd 10304 5 was be VBD cord-010119-t1x9gknd 10304 6 calculated calculate VBN cord-010119-t1x9gknd 10304 7 for for IN cord-010119-t1x9gknd 10304 8 the the DT cord-010119-t1x9gknd 10304 9 HBsAg hbsag CD cord-010119-t1x9gknd 10304 10 assay assay NN cord-010119-t1x9gknd 10304 11 using use VBG cord-010119-t1x9gknd 10304 12 production production NN cord-010119-t1x9gknd 10304 13 pools pool NNS cord-010119-t1x9gknd 10304 14 containing contain VBG cord-010119-t1x9gknd 10304 15 low low JJ cord-010119-t1x9gknd 10304 16 , , , cord-010119-t1x9gknd 10304 17 typical typical JJ cord-010119-t1x9gknd 10304 18 and and CC cord-010119-t1x9gknd 10304 19 high high JJ cord-010119-t1x9gknd 10304 20 anti anti NNS cord-010119-t1x9gknd 10304 21 - - JJ cord-010119-t1x9gknd 10304 22 HBsAg hbsag JJ cord-010119-t1x9gknd 10304 23 titers titer NNS cord-010119-t1x9gknd 10304 24 . . . cord-010119-t1x9gknd 10305 1 Intra intra JJ cord-010119-t1x9gknd 10305 2 - - JJ cord-010119-t1x9gknd 10305 3 assay assay NN cord-010119-t1x9gknd 10305 4 variability variability NN cord-010119-t1x9gknd 10305 5 was be VBD cord-010119-t1x9gknd 10305 6 determined determine VBN cord-010119-t1x9gknd 10305 7 by by IN cord-010119-t1x9gknd 10305 8 testing test VBG cord-010119-t1x9gknd 10305 9 a a DT cord-010119-t1x9gknd 10305 10 minimum minimum NN cord-010119-t1x9gknd 10305 11 of of IN cord-010119-t1x9gknd 10305 12 6 6 CD cord-010119-t1x9gknd 10305 13 determinations determination NNS cord-010119-t1x9gknd 10305 14 of of IN cord-010119-t1x9gknd 10305 15 a a DT cord-010119-t1x9gknd 10305 16 low low JJ cord-010119-t1x9gknd 10305 17 positive positive JJ cord-010119-t1x9gknd 10305 18 control control NN cord-010119-t1x9gknd 10305 19 in in IN cord-010119-t1x9gknd 10305 20 1 1 CD cord-010119-t1x9gknd 10305 21 run run NN cord-010119-t1x9gknd 10305 22 . . . cord-010119-t1x9gknd 10306 1 Inter inter JJ cord-010119-t1x9gknd 10306 2 - - JJ cord-010119-t1x9gknd 10306 3 assay assay NN cord-010119-t1x9gknd 10306 4 variability variability NN cord-010119-t1x9gknd 10306 5 was be VBD cord-010119-t1x9gknd 10306 6 determined determine VBN cord-010119-t1x9gknd 10306 7 by by IN cord-010119-t1x9gknd 10306 8 testing test VBG cord-010119-t1x9gknd 10306 9 at at RB cord-010119-t1x9gknd 10306 10 least least RBS cord-010119-t1x9gknd 10306 11 3 3 CD cord-010119-t1x9gknd 10306 12 representative representative JJ cord-010119-t1x9gknd 10306 13 negative negative JJ cord-010119-t1x9gknd 10306 14 production production NN cord-010119-t1x9gknd 10306 15 pool pool NN cord-010119-t1x9gknd 10306 16 samples sample NNS cord-010119-t1x9gknd 10306 17 , , , cord-010119-t1x9gknd 10306 18 at at IN cord-010119-t1x9gknd 10306 19 least least JJS cord-010119-t1x9gknd 10306 20 1 1 CD cord-010119-t1x9gknd 10306 21 low low JJ cord-010119-t1x9gknd 10306 22 positive positive JJ cord-010119-t1x9gknd 10306 23 sample sample NN cord-010119-t1x9gknd 10306 24 ( ( -LRB- cord-010119-t1x9gknd 10306 25 about about RB cord-010119-t1x9gknd 10306 26 3 3 CD cord-010119-t1x9gknd 10306 27 S S NNP cord-010119-t1x9gknd 10306 28 / / SYM cord-010119-t1x9gknd 10306 29 CO CO NNP cord-010119-t1x9gknd 10306 30 ) ) -RRB- cord-010119-t1x9gknd 10306 31 and and CC cord-010119-t1x9gknd 10306 32 a a DT cord-010119-t1x9gknd 10306 33 titration titration NN cord-010119-t1x9gknd 10306 34 series series NN cord-010119-t1x9gknd 10306 35 of of IN cord-010119-t1x9gknd 10306 36 WHO WHO NNP cord-010119-t1x9gknd 10306 37 standard standard NN cord-010119-t1x9gknd 10306 38 spiked spike VBD cord-010119-t1x9gknd 10306 39 into into IN cord-010119-t1x9gknd 10306 40 plasma plasma NN cord-010119-t1x9gknd 10306 41 production production NN cord-010119-t1x9gknd 10306 42 samples sample NNS cord-010119-t1x9gknd 10306 43 . . . cord-010119-t1x9gknd 10307 1 Runs run NNS cord-010119-t1x9gknd 10307 2 were be VBD cord-010119-t1x9gknd 10307 3 performed perform VBN cord-010119-t1x9gknd 10307 4 on on IN cord-010119-t1x9gknd 10307 5 six six CD cord-010119-t1x9gknd 10307 6 separate separate JJ cord-010119-t1x9gknd 10307 7 days day NNS cord-010119-t1x9gknd 10307 8 using use VBG cord-010119-t1x9gknd 10307 9 two two CD cord-010119-t1x9gknd 10307 10 different different JJ cord-010119-t1x9gknd 10307 11 instruments instrument NNS cord-010119-t1x9gknd 10307 12 and and CC cord-010119-t1x9gknd 10307 13 two two CD cord-010119-t1x9gknd 10307 14 different different JJ cord-010119-t1x9gknd 10307 15 lots lot NNS cord-010119-t1x9gknd 10307 16 of of IN cord-010119-t1x9gknd 10307 17 assay assay NN cord-010119-t1x9gknd 10307 18 reagents reagent NNS cord-010119-t1x9gknd 10307 19 . . . cord-010119-t1x9gknd 10308 1 Results/ Results/ . cord-010119-t1x9gknd 10309 1 Finding finding NN cord-010119-t1x9gknd 10309 2 : : : cord-010119-t1x9gknd 10310 1 The the DT cord-010119-t1x9gknd 10310 2 lower lower RBR cord-010119-t1x9gknd 10310 3 calculated calculate VBN cord-010119-t1x9gknd 10310 4 cutoff cutoff NN cord-010119-t1x9gknd 10310 5 values value NNS cord-010119-t1x9gknd 10310 6 for for IN cord-010119-t1x9gknd 10310 7 the the DT cord-010119-t1x9gknd 10310 8 HBsAg hbsag CD cord-010119-t1x9gknd 10310 9 and and CC cord-010119-t1x9gknd 10310 10 anti anti JJ cord-010119-t1x9gknd 10310 11 - - JJ cord-010119-t1x9gknd 10310 12 HIV hiv JJ cord-010119-t1x9gknd 10310 13 assays assay NNS cord-010119-t1x9gknd 10310 14 were be VBD cord-010119-t1x9gknd 10310 15 both both DT cord-010119-t1x9gknd 10310 16 below below IN cord-010119-t1x9gknd 10310 17 the the DT cord-010119-t1x9gknd 10310 18 manufacturer manufacturer NN cord-010119-t1x9gknd 10310 19 cutoffs cutoff NNS cord-010119-t1x9gknd 10310 20 of of IN cord-010119-t1x9gknd 10310 21 1.00 1.00 CD cord-010119-t1x9gknd 10310 22 and and CC cord-010119-t1x9gknd 10310 23 were be VBD cord-010119-t1x9gknd 10310 24 0.72 0.72 CD cord-010119-t1x9gknd 10310 25 and and CC cord-010119-t1x9gknd 10310 26 0.48 0.48 CD cord-010119-t1x9gknd 10310 27 respectively respectively RB cord-010119-t1x9gknd 10310 28 . . . cord-010119-t1x9gknd 10311 1 The the DT cord-010119-t1x9gknd 10311 2 HBsAg hbsag CD cord-010119-t1x9gknd 10311 3 assay assay NN cord-010119-t1x9gknd 10311 4 detection detection NN cord-010119-t1x9gknd 10311 5 limit limit NN cord-010119-t1x9gknd 10311 6 was be VBD cord-010119-t1x9gknd 10311 7 0.065 0.065 CD cord-010119-t1x9gknd 10311 8 IU/ iu/ NN cord-010119-t1x9gknd 10311 9 mL ml NN cord-010119-t1x9gknd 10311 10 for for IN cord-010119-t1x9gknd 10311 11 source source NN cord-010119-t1x9gknd 10311 12 plasma plasma NN cord-010119-t1x9gknd 10311 13 and and CC cord-010119-t1x9gknd 10311 14 0.120 0.120 CD cord-010119-t1x9gknd 10311 15 IU IU NNP cord-010119-t1x9gknd 10311 16 / / , cord-010119-t1x9gknd 10311 17 mL ml NN cord-010119-t1x9gknd 10311 18 for for IN cord-010119-t1x9gknd 10311 19 recovered recovered JJ cord-010119-t1x9gknd 10311 20 plasma plasma NN cord-010119-t1x9gknd 10311 21 samples sample NNS cord-010119-t1x9gknd 10311 22 . . . cord-010119-t1x9gknd 10312 1 The the DT cord-010119-t1x9gknd 10312 2 normalized normalized JJ cord-010119-t1x9gknd 10312 3 detection detection NN cord-010119-t1x9gknd 10312 4 limit limit NN cord-010119-t1x9gknd 10312 5 study study NN cord-010119-t1x9gknd 10312 6 demonstrated demonstrate VBD cord-010119-t1x9gknd 10312 7 that that IN cord-010119-t1x9gknd 10312 8 one one CD cord-010119-t1x9gknd 10312 9 and and CC cord-010119-t1x9gknd 10312 10 a a DT cord-010119-t1x9gknd 10312 11 half half NN cord-010119-t1x9gknd 10312 12 hours hour NNS cord-010119-t1x9gknd 10312 13 was be VBD cord-010119-t1x9gknd 10312 14 the the DT cord-010119-t1x9gknd 10312 15 maximum maximum JJ cord-010119-t1x9gknd 10312 16 amount amount NN cord-010119-t1x9gknd 10312 17 of of IN cord-010119-t1x9gknd 10312 18 time time NN cord-010119-t1x9gknd 10312 19 the the DT cord-010119-t1x9gknd 10312 20 pool pool NN cord-010119-t1x9gknd 10312 21 samples sample NNS cord-010119-t1x9gknd 10312 22 could could MD cord-010119-t1x9gknd 10312 23 sit sit VB cord-010119-t1x9gknd 10312 24 at at IN cord-010119-t1x9gknd 10312 25 15 15 CD cord-010119-t1x9gknd 10312 26 - - SYM cord-010119-t1x9gknd 10312 27 25 25 CD cord-010119-t1x9gknd 10312 28 0 0 CD cord-010119-t1x9gknd 10312 29 C c NN cord-010119-t1x9gknd 10312 30 where where WRB cord-010119-t1x9gknd 10312 31 all all DT cord-010119-t1x9gknd 10312 32 samples sample NNS cord-010119-t1x9gknd 10312 33 were be VBD cord-010119-t1x9gknd 10312 34 still still RB cord-010119-t1x9gknd 10312 35 reactive reactive JJ cord-010119-t1x9gknd 10312 36 for for IN cord-010119-t1x9gknd 10312 37 HBsAg hbsag ADD cord-010119-t1x9gknd 10312 38 . . . cord-010119-t1x9gknd 10313 1 The the DT cord-010119-t1x9gknd 10313 2 anti anti JJ cord-010119-t1x9gknd 10313 3 - - JJ cord-010119-t1x9gknd 10313 4 HIV HIV NNP cord-010119-t1x9gknd 10313 5 lowest low JJS cord-010119-t1x9gknd 10313 6 positive positive JJ cord-010119-t1x9gknd 10313 7 dilution dilution NN cord-010119-t1x9gknd 10313 8 for for IN cord-010119-t1x9gknd 10313 9 all all DT cord-010119-t1x9gknd 10313 10 replicates replicate NNS cord-010119-t1x9gknd 10313 11 varied varied JJ cord-010119-t1x9gknd 10313 12 between between IN cord-010119-t1x9gknd 10313 13 1:10,000 1:10,000 CD cord-010119-t1x9gknd 10313 14 to to IN cord-010119-t1x9gknd 10313 15 1 1 CD cord-010119-t1x9gknd 10313 16 : : : cord-010119-t1x9gknd 10313 17 1,250,000 1,250,000 CD cord-010119-t1x9gknd 10313 18 depending depend VBG cord-010119-t1x9gknd 10313 19 on on IN cord-010119-t1x9gknd 10313 20 subtype subtype NN cord-010119-t1x9gknd 10313 21 and and CC cord-010119-t1x9gknd 10313 22 group group NN cord-010119-t1x9gknd 10313 23 . . . cord-010119-t1x9gknd 10314 1 The the DT cord-010119-t1x9gknd 10314 2 % % NN cord-010119-t1x9gknd 10314 3 CV cv NN cord-010119-t1x9gknd 10314 4 of of IN cord-010119-t1x9gknd 10314 5 the the DT cord-010119-t1x9gknd 10314 6 S S NNP cord-010119-t1x9gknd 10314 7 / / SYM cord-010119-t1x9gknd 10314 8 CO CO NNP cord-010119-t1x9gknd 10314 9 values value NNS cord-010119-t1x9gknd 10314 10 of of IN cord-010119-t1x9gknd 10314 11 the the DT cord-010119-t1x9gknd 10314 12 replicates replicate NNS cord-010119-t1x9gknd 10314 13 of of IN cord-010119-t1x9gknd 10314 14 the the DT cord-010119-t1x9gknd 10314 15 intra intra JJ cord-010119-t1x9gknd 10314 16 - - JJ cord-010119-t1x9gknd 10314 17 assay assay JJ cord-010119-t1x9gknd 10314 18 variability variability NN cord-010119-t1x9gknd 10314 19 validation validation NN cord-010119-t1x9gknd 10314 20 were be VBD cord-010119-t1x9gknd 10314 21 less less JJR cord-010119-t1x9gknd 10314 22 than than IN cord-010119-t1x9gknd 10314 23 5 5 CD cord-010119-t1x9gknd 10314 24 % % NN cord-010119-t1x9gknd 10314 25 for for IN cord-010119-t1x9gknd 10314 26 both both DT cord-010119-t1x9gknd 10314 27 assays assay NNS cord-010119-t1x9gknd 10314 28 . . . cord-010119-t1x9gknd 10315 1 The the DT cord-010119-t1x9gknd 10315 2 % % NN cord-010119-t1x9gknd 10315 3 CV cv NN cord-010119-t1x9gknd 10315 4 of of IN cord-010119-t1x9gknd 10315 5 the the DT cord-010119-t1x9gknd 10315 6 S S NNP cord-010119-t1x9gknd 10315 7 / / SYM cord-010119-t1x9gknd 10315 8 CO CO NNP cord-010119-t1x9gknd 10315 9 values value NNS cord-010119-t1x9gknd 10315 10 of of IN cord-010119-t1x9gknd 10315 11 the the DT cord-010119-t1x9gknd 10315 12 panel panel NN cord-010119-t1x9gknd 10315 13 of of IN cord-010119-t1x9gknd 10315 14 samples sample NNS cord-010119-t1x9gknd 10315 15 of of IN cord-010119-t1x9gknd 10315 16 the the DT cord-010119-t1x9gknd 10315 17 inter inter JJ cord-010119-t1x9gknd 10315 18 - - JJ cord-010119-t1x9gknd 10315 19 assay assay JJ cord-010119-t1x9gknd 10315 20 variability variability NN cord-010119-t1x9gknd 10315 21 validation validation NN cord-010119-t1x9gknd 10315 22 were be VBD cord-010119-t1x9gknd 10315 23 less less JJR cord-010119-t1x9gknd 10315 24 than than IN cord-010119-t1x9gknd 10315 25 14 14 CD cord-010119-t1x9gknd 10315 26 % % NN cord-010119-t1x9gknd 10315 27 . . . cord-010119-t1x9gknd 10316 1 Conclusion conclusion NN cord-010119-t1x9gknd 10316 2 : : : cord-010119-t1x9gknd 10317 1 A a DT cord-010119-t1x9gknd 10317 2 lower lower RBR cord-010119-t1x9gknd 10317 3 calculated calculate VBN cord-010119-t1x9gknd 10317 4 cutoff cutoff NN cord-010119-t1x9gknd 10317 5 value value NN cord-010119-t1x9gknd 10317 6 could could MD cord-010119-t1x9gknd 10317 7 be be VB cord-010119-t1x9gknd 10317 8 determined determine VBN cord-010119-t1x9gknd 10317 9 for for IN cord-010119-t1x9gknd 10317 10 commercially commercially RB cord-010119-t1x9gknd 10317 11 available available JJ cord-010119-t1x9gknd 10317 12 immunoassays immunoassay NNS cord-010119-t1x9gknd 10317 13 for for IN cord-010119-t1x9gknd 10317 14 HBsAg HBsAg NNP cord-010119-t1x9gknd 10317 15 and and CC cord-010119-t1x9gknd 10317 16 anti anti JJ cord-010119-t1x9gknd 10317 17 - - JJ cord-010119-t1x9gknd 10317 18 HIV HIV NNP cord-010119-t1x9gknd 10317 19 . . . cord-010119-t1x9gknd 10318 1 These these DT cord-010119-t1x9gknd 10318 2 immunoassays immunoassay NNS cord-010119-t1x9gknd 10318 3 could could MD cord-010119-t1x9gknd 10318 4 meet meet VB cord-010119-t1x9gknd 10318 5 all all DT cord-010119-t1x9gknd 10318 6 of of IN cord-010119-t1x9gknd 10318 7 the the DT cord-010119-t1x9gknd 10318 8 recommendations recommendation NNS cord-010119-t1x9gknd 10318 9 in in IN cord-010119-t1x9gknd 10318 10 EMA EMA NNP cord-010119-t1x9gknd 10318 11 validation validation NN cord-010119-t1x9gknd 10318 12 guidelines guideline NNS cord-010119-t1x9gknd 10318 13 . . . cord-010119-t1x9gknd 10319 1 The the DT cord-010119-t1x9gknd 10319 2 ABBOTT ABBOTT NNP cord-010119-t1x9gknd 10319 3 PRISM PRISM NNP cord-010119-t1x9gknd 10319 4 HBsAg hbsag ADD cord-010119-t1x9gknd 10319 5 and and CC cord-010119-t1x9gknd 10319 6 HIV HIV NNP cord-010119-t1x9gknd 10319 7 O O NNP cord-010119-t1x9gknd 10319 8 Plus plus NN cord-010119-t1x9gknd 10319 9 assays assay NNS cord-010119-t1x9gknd 10319 10 can can MD cord-010119-t1x9gknd 10319 11 be be VB cord-010119-t1x9gknd 10319 12 utilized utilize VBN cord-010119-t1x9gknd 10319 13 to to TO cord-010119-t1x9gknd 10319 14 test test VB cord-010119-t1x9gknd 10319 15 production production NN cord-010119-t1x9gknd 10319 16 pool pool NN cord-010119-t1x9gknd 10319 17 samples sample NNS cord-010119-t1x9gknd 10319 18 . . . cord-010119-t1x9gknd 10320 1 was be VBD cord-010119-t1x9gknd 10320 2 performed perform VBN cord-010119-t1x9gknd 10320 3 on on IN cord-010119-t1x9gknd 10320 4 6 6 CD cord-010119-t1x9gknd 10320 5 donors donor NNS cord-010119-t1x9gknd 10320 6 ( ( -LRB- cord-010119-t1x9gknd 10320 7 3 3 CD cord-010119-t1x9gknd 10320 8 - - SYM cord-010119-t1x9gknd 10320 9 17 17 CD cord-010119-t1x9gknd 10320 10 days day NNS cord-010119-t1x9gknd 10320 11 after after IN cord-010119-t1x9gknd 10320 12 the the DT cord-010119-t1x9gknd 10320 13 index index NN cord-010119-t1x9gknd 10320 14 donation donation NN cord-010119-t1x9gknd 10320 15 ) ) -RRB- cord-010119-t1x9gknd 10321 1 -3 -3 NNP cord-010119-t1x9gknd 10322 1 donors donor NNS cord-010119-t1x9gknd 10322 2 in in IN cord-010119-t1x9gknd 10322 3 the the DT cord-010119-t1x9gknd 10322 4 follow follow NN cord-010119-t1x9gknd 10322 5 up up RP cord-010119-t1x9gknd 10322 6 study study NN cord-010119-t1x9gknd 10322 7 and and CC cord-010119-t1x9gknd 10322 8 3 3 CD cord-010119-t1x9gknd 10322 9 tested test VBN cord-010119-t1x9gknd 10322 10 by by IN cord-010119-t1x9gknd 10322 11 the the DT cord-010119-t1x9gknd 10322 12 DOH DOH NNP cord-010119-t1x9gknd 10322 13 . . . cord-010119-t1x9gknd 10323 1 No no DT cord-010119-t1x9gknd 10323 2 donors donor NNS cord-010119-t1x9gknd 10323 3 tested test VBN cord-010119-t1x9gknd 10323 4 by by IN cord-010119-t1x9gknd 10323 5 the the DT cord-010119-t1x9gknd 10323 6 DOH DOH NNP cord-010119-t1x9gknd 10323 7 participated participate VBD cord-010119-t1x9gknd 10323 8 in in IN cord-010119-t1x9gknd 10323 9 the the DT cord-010119-t1x9gknd 10323 10 follow follow NN cord-010119-t1x9gknd 10323 11 up up RP cord-010119-t1x9gknd 10323 12 study study NN cord-010119-t1x9gknd 10323 13 . . . cord-010119-t1x9gknd 10324 1 Follow follow VB cord-010119-t1x9gknd 10324 2 up up RP cord-010119-t1x9gknd 10324 3 testing testing NN cord-010119-t1x9gknd 10324 4 was be VBD cord-010119-t1x9gknd 10324 5 negative negative JJ cord-010119-t1x9gknd 10324 6 for for IN cord-010119-t1x9gknd 10324 7 all all DT cord-010119-t1x9gknd 10324 8 6 6 CD cord-010119-t1x9gknd 10324 9 donors donor NNS cord-010119-t1x9gknd 10324 10 . . . cord-010119-t1x9gknd 10325 1 DENV DENV NNP cord-010119-t1x9gknd 10325 2 antibodies antibody NNS cord-010119-t1x9gknd 10325 3 were be VBD cord-010119-t1x9gknd 10325 4 negative negative JJ cord-010119-t1x9gknd 10325 5 in in IN cord-010119-t1x9gknd 10325 6 9 9 CD cord-010119-t1x9gknd 10325 7 donations donation NNS cord-010119-t1x9gknd 10325 8 and and CC cord-010119-t1x9gknd 10325 9 equivocal equivocal JJ cord-010119-t1x9gknd 10325 10 in in IN cord-010119-t1x9gknd 10325 11 1 1 CD cord-010119-t1x9gknd 10325 12 . . . cord-010119-t1x9gknd 10326 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10326 2 initial initial JJ cord-010119-t1x9gknd 10326 3 reactive reactive JJ cord-010119-t1x9gknd 10326 4 rate rate NN cord-010119-t1x9gknd 10326 5 is be VBZ cord-010119-t1x9gknd 10326 6 higher high JJR cord-010119-t1x9gknd 10326 7 than than IN cord-010119-t1x9gknd 10326 8 that that DT cord-010119-t1x9gknd 10326 9 reported report VBD cord-010119-t1x9gknd 10326 10 to to IN cord-010119-t1x9gknd 10326 11 date date NN cord-010119-t1x9gknd 10326 12 for for IN cord-010119-t1x9gknd 10326 13 the the DT cord-010119-t1x9gknd 10326 14 Procleix Procleix NNP cord-010119-t1x9gknd 10326 15 ZIKV ZIKV NNP cord-010119-t1x9gknd 10326 16 TMA TMA NNP cord-010119-t1x9gknd 10326 17 of of IN cord-010119-t1x9gknd 10326 18 1 1 CD cord-010119-t1x9gknd 10326 19 per per IN cord-010119-t1x9gknd 10326 20 23 23 CD cord-010119-t1x9gknd 10326 21 , , , cord-010119-t1x9gknd 10326 22 342 342 CD cord-010119-t1x9gknd 10326 23 [ [ -LRB- cord-010119-t1x9gknd 10326 24 P. P. NNP cord-010119-t1x9gknd 10326 25 Williamson Williamson NNP cord-010119-t1x9gknd 10326 26 , , , cord-010119-t1x9gknd 10326 27 et et NNP cord-010119-t1x9gknd 10326 28 al al NNP cord-010119-t1x9gknd 10326 29 Transfusion Transfusion NNP cord-010119-t1x9gknd 10326 30 , , , cord-010119-t1x9gknd 10326 31 in in IN cord-010119-t1x9gknd 10326 32 press press NN cord-010119-t1x9gknd 10326 33 ] ] -RRB- cord-010119-t1x9gknd 10326 34 . . . cord-010119-t1x9gknd 10327 1 Conclusion conclusion NN cord-010119-t1x9gknd 10327 2 : : : cord-010119-t1x9gknd 10327 3 Universal universal JJ cord-010119-t1x9gknd 10327 4 testing testing NN cord-010119-t1x9gknd 10327 5 under under IN cord-010119-t1x9gknd 10327 6 IND IND NNP cord-010119-t1x9gknd 10327 7 was be VBD cord-010119-t1x9gknd 10327 8 successfully successfully RB cord-010119-t1x9gknd 10327 9 implemented implement VBN cord-010119-t1x9gknd 10327 10 and and CC cord-010119-t1x9gknd 10327 11 incorporated incorporate VBN cord-010119-t1x9gknd 10327 12 into into IN cord-010119-t1x9gknd 10327 13 blood blood NN cord-010119-t1x9gknd 10327 14 center center NN cord-010119-t1x9gknd 10327 15 operations operation NNS cord-010119-t1x9gknd 10327 16 . . . cord-010119-t1x9gknd 10328 1 We -PRON- PRP cord-010119-t1x9gknd 10328 2 have have VBP cord-010119-t1x9gknd 10328 3 noted note VBN cord-010119-t1x9gknd 10328 4 an an DT cord-010119-t1x9gknd 10328 5 initial initial JJ cord-010119-t1x9gknd 10328 6 reactive reactive JJ cord-010119-t1x9gknd 10328 7 Other other JJ cord-010119-t1x9gknd 10328 8 demographics demographic NNS cord-010119-t1x9gknd 10328 9 that that WDT cord-010119-t1x9gknd 10328 10 should should MD cord-010119-t1x9gknd 10328 11 be be VB cord-010119-t1x9gknd 10328 12 analyzed analyze VBN cord-010119-t1x9gknd 10328 13 for for IN cord-010119-t1x9gknd 10328 14 their -PRON- PRP$ cord-010119-t1x9gknd 10328 15 potential potential NN cord-010119-t1x9gknd 10328 16 to to TO cord-010119-t1x9gknd 10328 17 be be VB cord-010119-t1x9gknd 10328 18 used use VBN cord-010119-t1x9gknd 10328 19 to to TO cord-010119-t1x9gknd 10328 20 predict predict VB cord-010119-t1x9gknd 10328 21 CMV CMV NNP cord-010119-t1x9gknd 10328 22 seroconversion seroconversion NN cord-010119-t1x9gknd 10328 23 rate rate NN cord-010119-t1x9gknd 10328 24 include include VBP cord-010119-t1x9gknd 10328 25 gender gender NN cord-010119-t1x9gknd 10328 26 , , , cord-010119-t1x9gknd 10328 27 age age NN cord-010119-t1x9gknd 10328 28 , , , cord-010119-t1x9gknd 10328 29 race race NN cord-010119-t1x9gknd 10328 30 , , , cord-010119-t1x9gknd 10328 31 ethnicity ethnicity NN cord-010119-t1x9gknd 10328 32 or or CC cord-010119-t1x9gknd 10328 33 a a DT cord-010119-t1x9gknd 10328 34 combination combination NN cord-010119-t1x9gknd 10328 35 of of IN cord-010119-t1x9gknd 10328 36 these these DT cord-010119-t1x9gknd 10328 37 . . . cord-010119-t1x9gknd 10329 1 Background Background NNP cord-010119-t1x9gknd 10329 2 / / SYM cord-010119-t1x9gknd 10329 3 Case Case NNP cord-010119-t1x9gknd 10329 4 Studies Studies NNPS cord-010119-t1x9gknd 10329 5 : : : cord-010119-t1x9gknd 10329 6 Growing grow VBG cord-010119-t1x9gknd 10329 7 the the DT cord-010119-t1x9gknd 10329 8 geographic geographic JJ cord-010119-t1x9gknd 10329 9 footprint footprint NN cord-010119-t1x9gknd 10329 10 has have VBZ cord-010119-t1x9gknd 10329 11 been be VBN cord-010119-t1x9gknd 10329 12 a a DT cord-010119-t1x9gknd 10329 13 priority priority NN cord-010119-t1x9gknd 10329 14 for for IN cord-010119-t1x9gknd 10329 15 the the DT cord-010119-t1x9gknd 10329 16 organization organization NN cord-010119-t1x9gknd 10329 17 since since IN cord-010119-t1x9gknd 10329 18 2014 2014 CD cord-010119-t1x9gknd 10329 19 . . . cord-010119-t1x9gknd 10330 1 Over over IN cord-010119-t1x9gknd 10330 2 a a DT cord-010119-t1x9gknd 10330 3 four four CD cord-010119-t1x9gknd 10330 4 year year NN cord-010119-t1x9gknd 10330 5 period period NN cord-010119-t1x9gknd 10330 6 , , , cord-010119-t1x9gknd 10330 7 the the DT cord-010119-t1x9gknd 10330 8 organization organization NN cord-010119-t1x9gknd 10330 9 doubled double VBD cord-010119-t1x9gknd 10330 10 the the DT cord-010119-t1x9gknd 10330 11 number number NN cord-010119-t1x9gknd 10330 12 of of IN cord-010119-t1x9gknd 10330 13 blood blood NN cord-010119-t1x9gknd 10330 14 centers center NNS cord-010119-t1x9gknd 10330 15 , , , cord-010119-t1x9gknd 10330 16 with with IN cord-010119-t1x9gknd 10330 17 continued continue VBN cord-010119-t1x9gknd 10330 18 growth growth NN cord-010119-t1x9gknd 10330 19 expected expect VBN cord-010119-t1x9gknd 10330 20 . . . cord-010119-t1x9gknd 10331 1 With with IN cord-010119-t1x9gknd 10331 2 the the DT cord-010119-t1x9gknd 10331 3 current current JJ cord-010119-t1x9gknd 10331 4 challenges challenge NNS cord-010119-t1x9gknd 10331 5 in in IN cord-010119-t1x9gknd 10331 6 the the DT cord-010119-t1x9gknd 10331 7 blood blood NN cord-010119-t1x9gknd 10331 8 industry industry NN cord-010119-t1x9gknd 10331 9 , , , cord-010119-t1x9gknd 10331 10 the the DT cord-010119-t1x9gknd 10331 11 audit audit NN cord-010119-t1x9gknd 10331 12 program program NN cord-010119-t1x9gknd 10331 13 needed need VBN cord-010119-t1x9gknd 10331 14 to to TO cord-010119-t1x9gknd 10331 15 be be VB cord-010119-t1x9gknd 10331 16 flexible flexible JJ cord-010119-t1x9gknd 10331 17 , , , cord-010119-t1x9gknd 10331 18 maximizing maximize VBG cord-010119-t1x9gknd 10331 19 efficiency efficiency NN cord-010119-t1x9gknd 10331 20 and and CC cord-010119-t1x9gknd 10331 21 capacity capacity NN cord-010119-t1x9gknd 10331 22 utilization utilization NN cord-010119-t1x9gknd 10331 23 , , , cord-010119-t1x9gknd 10331 24 and and CC cord-010119-t1x9gknd 10331 25 without without IN cord-010119-t1x9gknd 10331 26 increasing increase VBG cord-010119-t1x9gknd 10331 27 compliance compliance NN cord-010119-t1x9gknd 10331 28 risk risk NN cord-010119-t1x9gknd 10331 29 . . . cord-010119-t1x9gknd 10332 1 The the DT cord-010119-t1x9gknd 10332 2 internal internal JJ cord-010119-t1x9gknd 10332 3 audit audit NN cord-010119-t1x9gknd 10332 4 function function NN cord-010119-t1x9gknd 10332 5 was be VBD cord-010119-t1x9gknd 10332 6 centralized centralize VBN cord-010119-t1x9gknd 10332 7 in in IN cord-010119-t1x9gknd 10332 8 late late JJ cord-010119-t1x9gknd 10332 9 2011 2011 CD cord-010119-t1x9gknd 10332 10 , , , cord-010119-t1x9gknd 10332 11 for for IN cord-010119-t1x9gknd 10332 12 which which WDT cord-010119-t1x9gknd 10332 13 the the DT cord-010119-t1x9gknd 10332 14 program program NN cord-010119-t1x9gknd 10332 15 consisted consist VBD cord-010119-t1x9gknd 10332 16 of of IN cord-010119-t1x9gknd 10332 17 2 2 CD cord-010119-t1x9gknd 10332 18 types type NNS cord-010119-t1x9gknd 10332 19 of of IN cord-010119-t1x9gknd 10332 20 audits audits NN cord-010119-t1x9gknd 10332 21 , , , cord-010119-t1x9gknd 10332 22 an an DT cord-010119-t1x9gknd 10332 23 operational operational JJ cord-010119-t1x9gknd 10332 24 compliance compliance NN cord-010119-t1x9gknd 10332 25 audit audit NN cord-010119-t1x9gknd 10332 26 and and CC cord-010119-t1x9gknd 10332 27 a a DT cord-010119-t1x9gknd 10332 28 support support NN cord-010119-t1x9gknd 10332 29 systems system NNS cord-010119-t1x9gknd 10332 30 compliance compliance NN cord-010119-t1x9gknd 10332 31 audit audit NN cord-010119-t1x9gknd 10332 32 . . . cord-010119-t1x9gknd 10333 1 Each each DT cord-010119-t1x9gknd 10333 2 type type NN cord-010119-t1x9gknd 10333 3 was be VBD cord-010119-t1x9gknd 10333 4 performed perform VBN cord-010119-t1x9gknd 10333 5 twice twice RB cord-010119-t1x9gknd 10333 6 per per IN cord-010119-t1x9gknd 10333 7 year year NN cord-010119-t1x9gknd 10333 8 at at IN cord-010119-t1x9gknd 10333 9 each each DT cord-010119-t1x9gknd 10333 10 main main JJ cord-010119-t1x9gknd 10333 11 center center NN cord-010119-t1x9gknd 10333 12 . . . cord-010119-t1x9gknd 10334 1 This this DT cord-010119-t1x9gknd 10334 2 model model NN cord-010119-t1x9gknd 10334 3 was be VBD cord-010119-t1x9gknd 10334 4 no no RB cord-010119-t1x9gknd 10334 5 longer long RBR cord-010119-t1x9gknd 10334 6 serving serve VBG cord-010119-t1x9gknd 10334 7 the the DT cord-010119-t1x9gknd 10334 8 changing change VBG cord-010119-t1x9gknd 10334 9 organization organization NN cord-010119-t1x9gknd 10334 10 . . . cord-010119-t1x9gknd 10335 1 Study Study NNP cord-010119-t1x9gknd 10335 2 Design Design NNP cord-010119-t1x9gknd 10335 3 / / SYM cord-010119-t1x9gknd 10335 4 Methods method NNS cord-010119-t1x9gknd 10335 5 : : : cord-010119-t1x9gknd 10335 6 Lean lean VB cord-010119-t1x9gknd 10335 7 Six six CD cord-010119-t1x9gknd 10335 8 Sigma Sigma NNP cord-010119-t1x9gknd 10335 9 concepts concept NNS cord-010119-t1x9gknd 10335 10 were be VBD cord-010119-t1x9gknd 10335 11 applied apply VBN cord-010119-t1x9gknd 10335 12 to to IN cord-010119-t1x9gknd 10335 13 this this DT cord-010119-t1x9gknd 10335 14 project project NN cord-010119-t1x9gknd 10335 15 . . . cord-010119-t1x9gknd 10336 1 Survey survey NN cord-010119-t1x9gknd 10336 2 results result NNS cord-010119-t1x9gknd 10336 3 and and CC cord-010119-t1x9gknd 10336 4 brainstorming brainstorming NN cord-010119-t1x9gknd 10336 5 aided aid VBN cord-010119-t1x9gknd 10336 6 in in IN cord-010119-t1x9gknd 10336 7 capturing capture VBG cord-010119-t1x9gknd 10336 8 the the DT cord-010119-t1x9gknd 10336 9 strengths strength NNS cord-010119-t1x9gknd 10336 10 of of IN cord-010119-t1x9gknd 10336 11 the the DT cord-010119-t1x9gknd 10336 12 current current JJ cord-010119-t1x9gknd 10336 13 program program NN cord-010119-t1x9gknd 10336 14 , , , cord-010119-t1x9gknd 10336 15 opportunities opportunity NNS cord-010119-t1x9gknd 10336 16 for for IN cord-010119-t1x9gknd 10336 17 improvement improvement NN cord-010119-t1x9gknd 10336 18 , , , cord-010119-t1x9gknd 10336 19 and and CC cord-010119-t1x9gknd 10336 20 ideas idea NNS cord-010119-t1x9gknd 10336 21 for for IN cord-010119-t1x9gknd 10336 22 a a DT cord-010119-t1x9gknd 10336 23 redesigned redesign VBN cord-010119-t1x9gknd 10336 24 program program NN cord-010119-t1x9gknd 10336 25 . . . cord-010119-t1x9gknd 10337 1 This this DT cord-010119-t1x9gknd 10337 2 information information NN cord-010119-t1x9gknd 10337 3 was be VBD cord-010119-t1x9gknd 10337 4 the the DT cord-010119-t1x9gknd 10337 5 primary primary JJ cord-010119-t1x9gknd 10337 6 input input NN cord-010119-t1x9gknd 10337 7 to to IN cord-010119-t1x9gknd 10337 8 the the DT cord-010119-t1x9gknd 10337 9 SWOT SWOT NNP cord-010119-t1x9gknd 10337 10 Analysis Analysis NNP cord-010119-t1x9gknd 10337 11 ( ( -LRB- cord-010119-t1x9gknd 10337 12 Strengths Strengths NNP cord-010119-t1x9gknd 10337 13 , , , cord-010119-t1x9gknd 10337 14 Weaknesses Weaknesses NNPS cord-010119-t1x9gknd 10337 15 , , , cord-010119-t1x9gknd 10337 16 Opportunities Opportunities NNPS cord-010119-t1x9gknd 10337 17 , , , cord-010119-t1x9gknd 10337 18 and and CC cord-010119-t1x9gknd 10337 19 Threats Threats NNPS cord-010119-t1x9gknd 10337 20 ) ) -RRB- cord-010119-t1x9gknd 10337 21 for for IN cord-010119-t1x9gknd 10337 22 the the DT cord-010119-t1x9gknd 10337 23 purpose purpose NN cord-010119-t1x9gknd 10337 24 of of IN cord-010119-t1x9gknd 10337 25 understanding understand VBG cord-010119-t1x9gknd 10337 26 performance performance NN cord-010119-t1x9gknd 10337 27 of of IN cord-010119-t1x9gknd 10337 28 the the DT cord-010119-t1x9gknd 10337 29 current current JJ cord-010119-t1x9gknd 10337 30 program program NN cord-010119-t1x9gknd 10337 31 , , , cord-010119-t1x9gknd 10337 32 as as RB cord-010119-t1x9gknd 10337 33 well well RB cord-010119-t1x9gknd 10337 34 as as IN cord-010119-t1x9gknd 10337 35 elements element NNS cord-010119-t1x9gknd 10337 36 that that WDT cord-010119-t1x9gknd 10337 37 could could MD cord-010119-t1x9gknd 10337 38 impact impact VB cord-010119-t1x9gknd 10337 39 the the DT cord-010119-t1x9gknd 10337 40 future future JJ cord-010119-t1x9gknd 10337 41 design design NN cord-010119-t1x9gknd 10337 42 . . . cord-010119-t1x9gknd 10338 1 Potential potential JJ cord-010119-t1x9gknd 10338 2 solutions solution NNS cord-010119-t1x9gknd 10338 3 were be VBD cord-010119-t1x9gknd 10338 4 placed place VBN cord-010119-t1x9gknd 10338 5 into into IN cord-010119-t1x9gknd 10338 6 a a DT cord-010119-t1x9gknd 10338 7 Pugh Pugh NNP cord-010119-t1x9gknd 10338 8 Matrix Matrix NNP cord-010119-t1x9gknd 10338 9 , , , cord-010119-t1x9gknd 10338 10 which which WDT cord-010119-t1x9gknd 10338 11 was be VBD cord-010119-t1x9gknd 10338 12 used use VBN cord-010119-t1x9gknd 10338 13 to to TO cord-010119-t1x9gknd 10338 14 facilitate facilitate VB cord-010119-t1x9gknd 10338 15 a a DT cord-010119-t1x9gknd 10338 16 disciplined disciplined JJ cord-010119-t1x9gknd 10338 17 , , , cord-010119-t1x9gknd 10338 18 team team NN cord-010119-t1x9gknd 10338 19 - - HYPH cord-010119-t1x9gknd 10338 20 based base VBN cord-010119-t1x9gknd 10338 21 process process NN cord-010119-t1x9gknd 10338 22 for for IN cord-010119-t1x9gknd 10338 23 concept concept NN cord-010119-t1x9gknd 10338 24 generation generation NN cord-010119-t1x9gknd 10338 25 and and CC cord-010119-t1x9gknd 10338 26 selection selection NN cord-010119-t1x9gknd 10338 27 . . . cord-010119-t1x9gknd 10339 1 Each each DT cord-010119-t1x9gknd 10339 2 potential potential JJ cord-010119-t1x9gknd 10339 3 solution solution NN cord-010119-t1x9gknd 10339 4 was be VBD cord-010119-t1x9gknd 10339 5 compared compare VBN cord-010119-t1x9gknd 10339 6 to to IN cord-010119-t1x9gknd 10339 7 criteria criterion NNS cord-010119-t1x9gknd 10339 8 for for IN cord-010119-t1x9gknd 10339 9 evaluation evaluation NN cord-010119-t1x9gknd 10339 10 and and CC cord-010119-t1x9gknd 10339 11 selection selection NN cord-010119-t1x9gknd 10339 12 of of IN cord-010119-t1x9gknd 10339 13 the the DT cord-010119-t1x9gknd 10339 14 best good JJS cord-010119-t1x9gknd 10339 15 solution solution NN cord-010119-t1x9gknd 10339 16 . . . cord-010119-t1x9gknd 10340 1 Results result NNS cord-010119-t1x9gknd 10340 2 / / SYM cord-010119-t1x9gknd 10340 3 Findings finding NNS cord-010119-t1x9gknd 10340 4 : : : cord-010119-t1x9gknd 10341 1 The the DT cord-010119-t1x9gknd 10341 2 program program NN cord-010119-t1x9gknd 10341 3 was be VBD cord-010119-t1x9gknd 10341 4 re re VBN cord-010119-t1x9gknd 10341 5 - - VBN cord-010119-t1x9gknd 10341 6 designed design VBN cord-010119-t1x9gknd 10341 7 to to TO cord-010119-t1x9gknd 10341 8 perform perform VB cord-010119-t1x9gknd 10341 9 internal internal JJ cord-010119-t1x9gknd 10341 10 audits audits NN cord-010119-t1x9gknd 10341 11 annually annually RB cord-010119-t1x9gknd 10341 12 as as IN cord-010119-t1x9gknd 10341 13 a a DT cord-010119-t1x9gknd 10341 14 single single JJ cord-010119-t1x9gknd 10341 15 , , , cord-010119-t1x9gknd 10341 16 team team NN cord-010119-t1x9gknd 10341 17 - - HYPH cord-010119-t1x9gknd 10341 18 based base VBN cord-010119-t1x9gknd 10341 19 comprehensive comprehensive JJ cord-010119-t1x9gknd 10341 20 audit audit NN cord-010119-t1x9gknd 10341 21 . . . cord-010119-t1x9gknd 10342 1 Remote remote JJ cord-010119-t1x9gknd 10342 2 auditing auditing NN cord-010119-t1x9gknd 10342 3 was be VBD cord-010119-t1x9gknd 10342 4 incorporated incorporate VBN cord-010119-t1x9gknd 10342 5 to to TO cord-010119-t1x9gknd 10342 6 require require VB cord-010119-t1x9gknd 10342 7 less less JJR cord-010119-t1x9gknd 10342 8 on on IN cord-010119-t1x9gknd 10342 9 - - HYPH cord-010119-t1x9gknd 10342 10 site site NN cord-010119-t1x9gknd 10342 11 time time NN cord-010119-t1x9gknd 10342 12 , , , cord-010119-t1x9gknd 10342 13 less less JJR cord-010119-t1x9gknd 10342 14 disruption disruption NN cord-010119-t1x9gknd 10342 15 , , , cord-010119-t1x9gknd 10342 16 improved improve VBN cord-010119-t1x9gknd 10342 17 auditor auditor NN cord-010119-t1x9gknd 10342 18 work work NN cord-010119-t1x9gknd 10342 19 / / SYM cord-010119-t1x9gknd 10342 20 life life NN cord-010119-t1x9gknd 10342 21 balance balance NN cord-010119-t1x9gknd 10342 22 , , , cord-010119-t1x9gknd 10342 23 and and CC cord-010119-t1x9gknd 10342 24 cost cost NN cord-010119-t1x9gknd 10342 25 savings saving NNS cord-010119-t1x9gknd 10342 26 . . . cord-010119-t1x9gknd 10343 1 A a DT cord-010119-t1x9gknd 10343 2 formula formula NN cord-010119-t1x9gknd 10343 3 was be VBD cord-010119-t1x9gknd 10343 4 created create VBN cord-010119-t1x9gknd 10343 5 to to TO cord-010119-t1x9gknd 10343 6 determine determine VB cord-010119-t1x9gknd 10343 7 on on IN cord-010119-t1x9gknd 10343 8 - - HYPH cord-010119-t1x9gknd 10343 9 site site NN cord-010119-t1x9gknd 10343 10 audit audit NN cord-010119-t1x9gknd 10343 11 time time NN cord-010119-t1x9gknd 10343 12 that that WDT cord-010119-t1x9gknd 10343 13 included include VBD cord-010119-t1x9gknd 10343 14 adjustable adjustable JJ cord-010119-t1x9gknd 10343 15 risk risk NN cord-010119-t1x9gknd 10343 16 factors factor NNS cord-010119-t1x9gknd 10343 17 . . . cord-010119-t1x9gknd 10344 1 The the DT cord-010119-t1x9gknd 10344 2 audit audit NN cord-010119-t1x9gknd 10344 3 reporting reporting NN cord-010119-t1x9gknd 10344 4 process process NN cord-010119-t1x9gknd 10344 5 was be VBD cord-010119-t1x9gknd 10344 6 also also RB cord-010119-t1x9gknd 10344 7 automated automate VBN cord-010119-t1x9gknd 10344 8 for for IN cord-010119-t1x9gknd 10344 9 simplification simplification NN cord-010119-t1x9gknd 10344 10 , , , cord-010119-t1x9gknd 10344 11 efficiency efficiency NN cord-010119-t1x9gknd 10344 12 , , , cord-010119-t1x9gknd 10344 13 and and CC cord-010119-t1x9gknd 10344 14 to to TO cord-010119-t1x9gknd 10344 15 meet meet VB cord-010119-t1x9gknd 10344 16 stakeholder stakeholder NN cord-010119-t1x9gknd 10344 17 needs need NNS cord-010119-t1x9gknd 10344 18 . . . cord-010119-t1x9gknd 10345 1 The the DT cord-010119-t1x9gknd 10345 2 team team NN cord-010119-t1x9gknd 10345 3 - - HYPH cord-010119-t1x9gknd 10345 4 based base VBN cord-010119-t1x9gknd 10345 5 approach approach NN cord-010119-t1x9gknd 10345 6 leverages leverage VBZ cord-010119-t1x9gknd 10345 7 auditor auditor NN cord-010119-t1x9gknd 10345 8 strengths strength NNS cord-010119-t1x9gknd 10345 9 , , , cord-010119-t1x9gknd 10345 10 fosters foster VBZ cord-010119-t1x9gknd 10345 11 a a DT cord-010119-t1x9gknd 10345 12 learning learning NN cord-010119-t1x9gknd 10345 13 environment environment NN cord-010119-t1x9gknd 10345 14 , , , cord-010119-t1x9gknd 10345 15 and and CC cord-010119-t1x9gknd 10345 16 increases increase VBZ cord-010119-t1x9gknd 10345 17 detectability detectability NN cord-010119-t1x9gknd 10345 18 of of IN cord-010119-t1x9gknd 10345 19 organization organization NN cord-010119-t1x9gknd 10345 20 - - HYPH cord-010119-t1x9gknd 10345 21 wide wide JJ cord-010119-t1x9gknd 10345 22 concerns concern NNS cord-010119-t1x9gknd 10345 23 . . . cord-010119-t1x9gknd 10346 1 Conclusion conclusion NN cord-010119-t1x9gknd 10346 2 : : : cord-010119-t1x9gknd 10347 1 The the DT cord-010119-t1x9gknd 10347 2 comprehensive comprehensive JJ cord-010119-t1x9gknd 10347 3 team team NN cord-010119-t1x9gknd 10347 4 - - HYPH cord-010119-t1x9gknd 10347 5 based base VBN cord-010119-t1x9gknd 10347 6 approach approach NN cord-010119-t1x9gknd 10347 7 , , , cord-010119-t1x9gknd 10347 8 and and CC cord-010119-t1x9gknd 10347 9 other other JJ cord-010119-t1x9gknd 10347 10 program program NN cord-010119-t1x9gknd 10347 11 improvements improvement NNS cord-010119-t1x9gknd 10347 12 , , , cord-010119-t1x9gknd 10347 13 has have VBZ cord-010119-t1x9gknd 10347 14 been be VBN cord-010119-t1x9gknd 10347 15 effective effective JJ cord-010119-t1x9gknd 10347 16 in in IN cord-010119-t1x9gknd 10347 17 responding respond VBG cord-010119-t1x9gknd 10347 18 to to IN cord-010119-t1x9gknd 10347 19 organizational organizational JJ cord-010119-t1x9gknd 10347 20 growth growth NN cord-010119-t1x9gknd 10347 21 without without IN cord-010119-t1x9gknd 10347 22 sacrificing sacrifice VBG cord-010119-t1x9gknd 10347 23 Quality quality NN cord-010119-t1x9gknd 10347 24 or or CC cord-010119-t1x9gknd 10347 25 increasing increase VBG cord-010119-t1x9gknd 10347 26 compliance compliance NN cord-010119-t1x9gknd 10347 27 risk risk NN cord-010119-t1x9gknd 10347 28 . . . cord-010119-t1x9gknd 10348 1 External external JJ cord-010119-t1x9gknd 10348 2 inspection inspection NN cord-010119-t1x9gknd 10348 3 performance performance NN cord-010119-t1x9gknd 10348 4 has have VBZ cord-010119-t1x9gknd 10348 5 achieved achieve VBN cord-010119-t1x9gknd 10348 6 record record JJ cord-010119-t1x9gknd 10348 7 performance performance NN cord-010119-t1x9gknd 10348 8 levels level NNS cord-010119-t1x9gknd 10348 9 the the DT cord-010119-t1x9gknd 10348 10 past past JJ cord-010119-t1x9gknd 10348 11 year year NN cord-010119-t1x9gknd 10348 12 . . . cord-010119-t1x9gknd 10349 1 Diversity diversity NN cord-010119-t1x9gknd 10349 2 of of IN cord-010119-t1x9gknd 10349 3 auditor auditor NN cord-010119-t1x9gknd 10349 4 skills skill NNS cord-010119-t1x9gknd 10349 5 led lead VBD cord-010119-t1x9gknd 10349 6 to to IN cord-010119-t1x9gknd 10349 7 a a DT cord-010119-t1x9gknd 10349 8 stronger strong JJR cord-010119-t1x9gknd 10349 9 skill skill NN cord-010119-t1x9gknd 10349 10 presence presence NN cord-010119-t1x9gknd 10349 11 , , , cord-010119-t1x9gknd 10349 12 which which WDT cord-010119-t1x9gknd 10349 13 was be VBD cord-010119-t1x9gknd 10349 14 consistently consistently RB cord-010119-t1x9gknd 10349 15 applied apply VBN cord-010119-t1x9gknd 10349 16 across across IN cord-010119-t1x9gknd 10349 17 system system NN cord-010119-t1x9gknd 10349 18 . . . cord-010119-t1x9gknd 10350 1 Auditing auditing NN cord-010119-t1x9gknd 10350 2 is be VBZ cord-010119-t1x9gknd 10350 3 more more RBR cord-010119-t1x9gknd 10350 4 efficient efficient JJ cord-010119-t1x9gknd 10350 5 and and CC cord-010119-t1x9gknd 10350 6 effective effective JJ cord-010119-t1x9gknd 10350 7 . . . cord-010119-t1x9gknd 10351 1 Stronger strong JJR cord-010119-t1x9gknd 10351 2 collaboration collaboration NN cord-010119-t1x9gknd 10351 3 among among IN cord-010119-t1x9gknd 10351 4 audit audit NN cord-010119-t1x9gknd 10351 5 team team NN cord-010119-t1x9gknd 10351 6 members member NNS cord-010119-t1x9gknd 10351 7 provided provide VBD cord-010119-t1x9gknd 10351 8 stronger strong JJR cord-010119-t1x9gknd 10351 9 objectivity objectivity NN cord-010119-t1x9gknd 10351 10 , , , cord-010119-t1x9gknd 10351 11 fairness fairness NN cord-010119-t1x9gknd 10351 12 , , , cord-010119-t1x9gknd 10351 13 and and CC cord-010119-t1x9gknd 10351 14 consistency consistency NN cord-010119-t1x9gknd 10351 15 across across IN cord-010119-t1x9gknd 10351 16 the the DT cord-010119-t1x9gknd 10351 17 system system NN cord-010119-t1x9gknd 10351 18 . . . cord-010119-t1x9gknd 10352 1 Auditors auditor NNS cord-010119-t1x9gknd 10352 2 and and CC cord-010119-t1x9gknd 10352 3 auditees auditee NNS cord-010119-t1x9gknd 10352 4 have have VBP cord-010119-t1x9gknd 10352 5 increased increase VBN cord-010119-t1x9gknd 10352 6 in in IN cord-010119-t1x9gknd 10352 7 knowledge knowledge NN cord-010119-t1x9gknd 10352 8 , , , cord-010119-t1x9gknd 10352 9 and and CC cord-010119-t1x9gknd 10352 10 the the DT cord-010119-t1x9gknd 10352 11 internal internal JJ cord-010119-t1x9gknd 10352 12 quality quality NN cord-010119-t1x9gknd 10352 13 audit audit NN cord-010119-t1x9gknd 10352 14 program program NN cord-010119-t1x9gknd 10352 15 has have VBZ cord-010119-t1x9gknd 10352 16 improved improve VBN cord-010119-t1x9gknd 10352 17 . . . cord-010119-t1x9gknd 10353 1 Background Background NNP cord-010119-t1x9gknd 10353 2 / / SYM cord-010119-t1x9gknd 10353 3 Case Case NNP cord-010119-t1x9gknd 10353 4 Studies Studies NNPS cord-010119-t1x9gknd 10353 5 : : : cord-010119-t1x9gknd 10353 6 In in IN cord-010119-t1x9gknd 10353 7 many many JJ cord-010119-t1x9gknd 10353 8 places place NNS cord-010119-t1x9gknd 10353 9 , , , cord-010119-t1x9gknd 10353 10 blood blood NN cord-010119-t1x9gknd 10353 11 banking banking NN cord-010119-t1x9gknd 10353 12 is be VBZ cord-010119-t1x9gknd 10353 13 using use VBG cord-010119-t1x9gknd 10353 14 semiautomated semiautomated JJ cord-010119-t1x9gknd 10353 15 systems system NNS cord-010119-t1x9gknd 10353 16 to to TO cord-010119-t1x9gknd 10353 17 perform perform VB cord-010119-t1x9gknd 10353 18 fractioning fractioning NN cord-010119-t1x9gknd 10353 19 in in IN cord-010119-t1x9gknd 10353 20 different different JJ cord-010119-t1x9gknd 10353 21 blood blood NN cord-010119-t1x9gknd 10353 22 components component NNS cord-010119-t1x9gknd 10353 23 ( ( -LRB- cord-010119-t1x9gknd 10353 24 red red JJ cord-010119-t1x9gknd 10353 25 blood blood NN cord-010119-t1x9gknd 10353 26 cells cell NNS cord-010119-t1x9gknd 10353 27 , , , cord-010119-t1x9gknd 10353 28 platelets platelet NNS cord-010119-t1x9gknd 10353 29 and and CC cord-010119-t1x9gknd 10353 30 plasma plasma NN cord-010119-t1x9gknd 10353 31 ) ) -RRB- cord-010119-t1x9gknd 10353 32 . . . cord-010119-t1x9gknd 10354 1 Banc Banc NNP cord-010119-t1x9gknd 10354 2 de de NNP cord-010119-t1x9gknd 10354 3 Sang Sang NNP cord-010119-t1x9gknd 10355 1 i i PRP cord-010119-t1x9gknd 10355 2 Teixits Teixits NNP cord-010119-t1x9gknd 10355 3 ( ( -LRB- cord-010119-t1x9gknd 10355 4 BST BST NNP cord-010119-t1x9gknd 10355 5 ) ) -RRB- cord-010119-t1x9gknd 10355 6 , , , cord-010119-t1x9gknd 10355 7 adopted adopt VBD cord-010119-t1x9gknd 10355 8 the the DT cord-010119-t1x9gknd 10355 9 fully fully RB cord-010119-t1x9gknd 10355 10 automated automate VBN cord-010119-t1x9gknd 10355 11 Reveos Reveos NNP cord-010119-t1x9gknd 10355 12 system system NN cord-010119-t1x9gknd 10355 13 ( ( -LRB- cord-010119-t1x9gknd 10355 14 Terumo Terumo NNP cord-010119-t1x9gknd 10355 15 BCT BCT NNP cord-010119-t1x9gknd 10355 16 Inc Inc NNP cord-010119-t1x9gknd 10355 17 , , , cord-010119-t1x9gknd 10355 18 Lakewood Lakewood NNP cord-010119-t1x9gknd 10355 19 , , , cord-010119-t1x9gknd 10355 20 CO CO NNP cord-010119-t1x9gknd 10355 21 ) ) -RRB- cord-010119-t1x9gknd 10355 22 few few JJ cord-010119-t1x9gknd 10355 23 years year NNS cord-010119-t1x9gknd 10355 24 ago ago RB cord-010119-t1x9gknd 10355 25 to to TO cord-010119-t1x9gknd 10355 26 manufacture manufacture VB cord-010119-t1x9gknd 10355 27 blood blood NN cord-010119-t1x9gknd 10355 28 components component NNS cord-010119-t1x9gknd 10355 29 . . . cord-010119-t1x9gknd 10356 1 In in IN cord-010119-t1x9gknd 10356 2 June June NNP cord-010119-t1x9gknd 10356 3 2016 2016 CD cord-010119-t1x9gknd 10356 4 , , , cord-010119-t1x9gknd 10356 5 BST BST NNP cord-010119-t1x9gknd 10356 6 started start VBD cord-010119-t1x9gknd 10356 7 a a DT cord-010119-t1x9gknd 10356 8 validation validation NN cord-010119-t1x9gknd 10356 9 of of IN cord-010119-t1x9gknd 10356 10 new new JJ cord-010119-t1x9gknd 10356 11 blood blood NN cord-010119-t1x9gknd 10356 12 bags bag NNS cord-010119-t1x9gknd 10356 13 manufactured manufacture VBN cord-010119-t1x9gknd 10356 14 by by IN cord-010119-t1x9gknd 10356 15 Terumo Terumo NNP cord-010119-t1x9gknd 10356 16 BCT BCT NNP cord-010119-t1x9gknd 10356 17 with with IN cord-010119-t1x9gknd 10356 18 different different JJ cord-010119-t1x9gknd 10356 19 variables variable NNS cord-010119-t1x9gknd 10356 20 on on IN cord-010119-t1x9gknd 10356 21 platelet platelet NN cord-010119-t1x9gknd 10356 22 volume volume NN cord-010119-t1x9gknd 10356 23 after after IN cord-010119-t1x9gknd 10356 24 processing processing NN cord-010119-t1x9gknd 10356 25 and and CC cord-010119-t1x9gknd 10356 26 a a DT cord-010119-t1x9gknd 10356 27 kit kit NN cord-010119-t1x9gknd 10356 28 to to TO cord-010119-t1x9gknd 10356 29 perform perform VB cord-010119-t1x9gknd 10356 30 platelets platelet NNS cord-010119-t1x9gknd 10356 31 pools pool NNS cord-010119-t1x9gknd 10356 32 with with IN cord-010119-t1x9gknd 10356 33 a a DT cord-010119-t1x9gknd 10356 34 new new JJ cord-010119-t1x9gknd 10356 35 filter filter NN cord-010119-t1x9gknd 10356 36 . . . cord-010119-t1x9gknd 10357 1 Study Study NNP cord-010119-t1x9gknd 10357 2 Design Design NNP cord-010119-t1x9gknd 10357 3 / / SYM cord-010119-t1x9gknd 10357 4 Method method NN cord-010119-t1x9gknd 10357 5 : : : cord-010119-t1x9gknd 10358 1 To to TO cord-010119-t1x9gknd 10358 2 perform perform VB cord-010119-t1x9gknd 10358 3 this this DT cord-010119-t1x9gknd 10358 4 validation validation NN cord-010119-t1x9gknd 10358 5 , , , cord-010119-t1x9gknd 10358 6 300 300 CD cord-010119-t1x9gknd 10358 7 blood blood NN cord-010119-t1x9gknd 10358 8 donations donation NNS cord-010119-t1x9gknd 10358 9 were be VBD cord-010119-t1x9gknd 10358 10 used use VBN cord-010119-t1x9gknd 10358 11 under under IN cord-010119-t1x9gknd 10358 12 different different JJ cord-010119-t1x9gknd 10358 13 conditions condition NNS cord-010119-t1x9gknd 10358 14 ( ( -LRB- cord-010119-t1x9gknd 10358 15 see see VB cord-010119-t1x9gknd 10358 16 Table table NN cord-010119-t1x9gknd 10358 17 below below RB cord-010119-t1x9gknd 10358 18 ) ) -RRB- cord-010119-t1x9gknd 10358 19 . . . cord-010119-t1x9gknd 10359 1 The the DT cord-010119-t1x9gknd 10359 2 current current JJ cord-010119-t1x9gknd 10359 3 filter filter NN cord-010119-t1x9gknd 10359 4 evaluated evaluate VBN cord-010119-t1x9gknd 10359 5 for for IN cord-010119-t1x9gknd 10359 6 the the DT cord-010119-t1x9gknd 10359 7 platelet platelet NN cord-010119-t1x9gknd 10359 8 pool pool NN cord-010119-t1x9gknd 10359 9 ( ( -LRB- cord-010119-t1x9gknd 10359 10 LRF LRF NNP cord-010119-t1x9gknd 10359 11 - - HYPH cord-010119-t1x9gknd 10359 12 XL XL NNP cord-010119-t1x9gknd 10359 13 , , , cord-010119-t1x9gknd 10359 14 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 10359 15 Corporation Corporation NNP cord-010119-t1x9gknd 10359 16 ) ) -RRB- cord-010119-t1x9gknd 10359 17 was be VBD cord-010119-t1x9gknd 10359 18 compared compare VBN cord-010119-t1x9gknd 10359 19 to to IN cord-010119-t1x9gknd 10359 20 a a DT cord-010119-t1x9gknd 10359 21 new new JJ cord-010119-t1x9gknd 10359 22 filter filter NN cord-010119-t1x9gknd 10359 23 ( ( -LRB- cord-010119-t1x9gknd 10359 24 Terumo Terumo NNP cord-010119-t1x9gknd 10359 25 BCT BCT NNP cord-010119-t1x9gknd 10359 26 Inc. Inc. NNP cord-010119-t1x9gknd 10359 27 ) ) -RRB- cord-010119-t1x9gknd 10359 28 . . . cord-010119-t1x9gknd 10360 1 The the DT cord-010119-t1x9gknd 10360 2 new new JJ cord-010119-t1x9gknd 10360 3 blood blood NN cord-010119-t1x9gknd 10360 4 bags bag NNS cord-010119-t1x9gknd 10360 5 were be VBD cord-010119-t1x9gknd 10360 6 manufactured manufacture VBN cord-010119-t1x9gknd 10360 7 using use VBG cord-010119-t1x9gknd 10360 8 a a DT cord-010119-t1x9gknd 10360 9 new new JJ cord-010119-t1x9gknd 10360 10 vinyl vinyl NN cord-010119-t1x9gknd 10360 11 supplier supplier NN cord-010119-t1x9gknd 10360 12 . . . cord-010119-t1x9gknd 10361 1 A a DT cord-010119-t1x9gknd 10361 2 portion portion NN cord-010119-t1x9gknd 10361 3 of of IN cord-010119-t1x9gknd 10361 4 these these DT cord-010119-t1x9gknd 10361 5 processed process VBN cord-010119-t1x9gknd 10361 6 blood blood NN cord-010119-t1x9gknd 10361 7 components component NNS cord-010119-t1x9gknd 10361 8 ( ( -LRB- cord-010119-t1x9gknd 10361 9 red red JJ cord-010119-t1x9gknd 10361 10 blood blood NN cord-010119-t1x9gknd 10361 11 cells cell NNS cord-010119-t1x9gknd 10361 12 , , , cord-010119-t1x9gknd 10361 13 platelets platelet NNS cord-010119-t1x9gknd 10361 14 and and CC cord-010119-t1x9gknd 10361 15 plasma plasma NN cord-010119-t1x9gknd 10361 16 ) ) -RRB- cord-010119-t1x9gknd 10361 17 was be VBD cord-010119-t1x9gknd 10361 18 used use VBN cord-010119-t1x9gknd 10361 19 for for IN cord-010119-t1x9gknd 10361 20 different different JJ cord-010119-t1x9gknd 10361 21 quality quality NN cord-010119-t1x9gknd 10361 22 control control NN cord-010119-t1x9gknd 10361 23 ( ( -LRB- cord-010119-t1x9gknd 10361 24 QC QC NNP cord-010119-t1x9gknd 10361 25 ) ) -RRB- cord-010119-t1x9gknd 10361 26 tests test NNS cord-010119-t1x9gknd 10361 27 ( ( -LRB- cord-010119-t1x9gknd 10361 28 routine routine JJ cord-010119-t1x9gknd 10361 29 QC QC NNP cord-010119-t1x9gknd 10361 30 performed perform VBN cord-010119-t1x9gknd 10361 31 at at IN cord-010119-t1x9gknd 10361 32 BST BST NNP cord-010119-t1x9gknd 10361 33 following follow VBG cord-010119-t1x9gknd 10361 34 European European NNP cord-010119-t1x9gknd 10361 35 Directorate Directorate NNP cord-010119-t1x9gknd 10361 36 for for IN cord-010119-t1x9gknd 10361 37 Quality Quality NNP cord-010119-t1x9gknd 10361 38 of of IN cord-010119-t1x9gknd 10361 39 Medicines Medicines NNP cord-010119-t1x9gknd 10361 40 & & CC cord-010119-t1x9gknd 10361 41 Healthcare Healthcare NNP cord-010119-t1x9gknd 10361 42 ; ; , cord-010119-t1x9gknd 10361 43 cytokine cytokine NN cord-010119-t1x9gknd 10361 44 analysis analysis NN cord-010119-t1x9gknd 10361 45 , , , cord-010119-t1x9gknd 10361 46 such such JJ cord-010119-t1x9gknd 10361 47 as as IN cord-010119-t1x9gknd 10361 48 P P NNP cord-010119-t1x9gknd 10361 49 - - : cord-010119-t1x9gknd 10361 50 Selectin Selectin NNP cord-010119-t1x9gknd 10361 51 and and CC cord-010119-t1x9gknd 10361 52 platelets platelet NNS cord-010119-t1x9gknd 10361 53 recovery recovery NN cord-010119-t1x9gknd 10361 54 through through IN cord-010119-t1x9gknd 10361 55 the the DT cord-010119-t1x9gknd 10361 56 filter filter NN cord-010119-t1x9gknd 10361 57 ) ) -RRB- cord-010119-t1x9gknd 10361 58 . . . cord-010119-t1x9gknd 10362 1 Results/ Results/ . cord-010119-t1x9gknd 10363 1 Finding find VBG cord-010119-t1x9gknd 10363 2 : : : cord-010119-t1x9gknd 10363 3 The the DT cord-010119-t1x9gknd 10363 4 results result NNS cord-010119-t1x9gknd 10363 5 are be VBP cord-010119-t1x9gknd 10363 6 very very RB cord-010119-t1x9gknd 10363 7 similar similar JJ cord-010119-t1x9gknd 10363 8 between between IN cord-010119-t1x9gknd 10363 9 both both DT cord-010119-t1x9gknd 10363 10 bags bag NNS cord-010119-t1x9gknd 10363 11 , , , cord-010119-t1x9gknd 10363 12 current current JJ cord-010119-t1x9gknd 10363 13 and and CC cord-010119-t1x9gknd 10363 14 new new JJ cord-010119-t1x9gknd 10363 15 one one CD cord-010119-t1x9gknd 10363 16 , , , cord-010119-t1x9gknd 10363 17 as as RB cord-010119-t1x9gknd 10363 18 well well RB cord-010119-t1x9gknd 10363 19 as as IN cord-010119-t1x9gknd 10363 20 filters filter NNS cord-010119-t1x9gknd 10363 21 . . . cord-010119-t1x9gknd 10364 1 All all PDT cord-010119-t1x9gknd 10364 2 the the DT cord-010119-t1x9gknd 10364 3 analysis analysis NN cord-010119-t1x9gknd 10364 4 done do VBN cord-010119-t1x9gknd 10364 5 to to TO cord-010119-t1x9gknd 10364 6 evaluate evaluate VB cord-010119-t1x9gknd 10364 7 the the DT cord-010119-t1x9gknd 10364 8 quality quality NN cord-010119-t1x9gknd 10364 9 of of IN cord-010119-t1x9gknd 10364 10 the the DT cord-010119-t1x9gknd 10364 11 blood blood NN cord-010119-t1x9gknd 10364 12 components component NNS cord-010119-t1x9gknd 10364 13 were be VBD cord-010119-t1x9gknd 10364 14 similar similar JJ cord-010119-t1x9gknd 10364 15 in in IN cord-010119-t1x9gknd 10364 16 all all DT cord-010119-t1x9gknd 10364 17 conditions condition NNS cord-010119-t1x9gknd 10364 18 . . . cord-010119-t1x9gknd 10365 1 Also also RB cord-010119-t1x9gknd 10365 2 , , , cord-010119-t1x9gknd 10365 3 it -PRON- PRP cord-010119-t1x9gknd 10365 4 was be VBD cord-010119-t1x9gknd 10365 5 shown show VBN cord-010119-t1x9gknd 10365 6 a a DT cord-010119-t1x9gknd 10365 7 better well JJR cord-010119-t1x9gknd 10365 8 performance performance NN cord-010119-t1x9gknd 10365 9 on on IN cord-010119-t1x9gknd 10365 10 platelets platelet NNS cord-010119-t1x9gknd 10365 11 pools pool NNS cord-010119-t1x9gknd 10365 12 , , , cord-010119-t1x9gknd 10365 13 when when WRB cord-010119-t1x9gknd 10365 14 they -PRON- PRP cord-010119-t1x9gknd 10365 15 came come VBD cord-010119-t1x9gknd 10365 16 from from IN cord-010119-t1x9gknd 10365 17 bags bag NNS cord-010119-t1x9gknd 10365 18 centrifuged centrifuge VBN cord-010119-t1x9gknd 10365 19 with with IN cord-010119-t1x9gknd 10365 20 60 60 CD cord-010119-t1x9gknd 10365 21 ml ml NNS cord-010119-t1x9gknd 10365 22 of of IN cord-010119-t1x9gknd 10365 23 plasma plasma NN cord-010119-t1x9gknd 10365 24 , , , cord-010119-t1x9gknd 10365 25 vs. vs. FW cord-010119-t1x9gknd 10365 26 30 30 CD cord-010119-t1x9gknd 10365 27 ml ml NNS cord-010119-t1x9gknd 10365 28 of of IN cord-010119-t1x9gknd 10365 29 plasma plasma NN cord-010119-t1x9gknd 10365 30 and and CC cord-010119-t1x9gknd 10365 31 additive additive NN cord-010119-t1x9gknd 10365 32 solution solution NN cord-010119-t1x9gknd 10365 33 . . . cord-010119-t1x9gknd 10366 1 Conclusion conclusion NN cord-010119-t1x9gknd 10366 2 : : : cord-010119-t1x9gknd 10367 1 These these DT cord-010119-t1x9gknd 10367 2 new new JJ cord-010119-t1x9gknd 10367 3 bags bag NNS cord-010119-t1x9gknd 10367 4 and and CC cord-010119-t1x9gknd 10367 5 filter filter NN cord-010119-t1x9gknd 10367 6 have have VBP cord-010119-t1x9gknd 10367 7 shown show VBN cord-010119-t1x9gknd 10367 8 a a DT cord-010119-t1x9gknd 10367 9 similar similar JJ cord-010119-t1x9gknd 10367 10 behavior behavior NN cord-010119-t1x9gknd 10367 11 when when WRB cord-010119-t1x9gknd 10367 12 using use VBG cord-010119-t1x9gknd 10367 13 them -PRON- PRP cord-010119-t1x9gknd 10367 14 for for IN cord-010119-t1x9gknd 10367 15 manufacturing manufacture VBG cord-010119-t1x9gknd 10367 16 blood blood NN cord-010119-t1x9gknd 10367 17 donations donation NNS cord-010119-t1x9gknd 10367 18 with with IN cord-010119-t1x9gknd 10367 19 Reveos Reveos NNP cord-010119-t1x9gknd 10367 20 system system NN cord-010119-t1x9gknd 10367 21 in in IN cord-010119-t1x9gknd 10367 22 our -PRON- PRP$ cord-010119-t1x9gknd 10367 23 blood blood NN cord-010119-t1x9gknd 10367 24 bank bank NN cord-010119-t1x9gknd 10367 25 . . . cord-010119-t1x9gknd 10368 1 Regarding regard VBG cord-010119-t1x9gknd 10368 2 the the DT cord-010119-t1x9gknd 10368 3 new new JJ cord-010119-t1x9gknd 10368 4 platelets platelet NNS cord-010119-t1x9gknd 10368 5 pooling pooling NN cord-010119-t1x9gknd 10368 6 kits kit NNS cord-010119-t1x9gknd 10368 7 , , , cord-010119-t1x9gknd 10368 8 a a DT cord-010119-t1x9gknd 10368 9 better well JJR cord-010119-t1x9gknd 10368 10 manipulation manipulation NN cord-010119-t1x9gknd 10368 11 by by IN cord-010119-t1x9gknd 10368 12 the the DT cord-010119-t1x9gknd 10368 13 operator operator NN cord-010119-t1x9gknd 10368 14 was be VBD cord-010119-t1x9gknd 10368 15 observed observe VBN cord-010119-t1x9gknd 10368 16 ; ; : cord-010119-t1x9gknd 10368 17 although although IN cord-010119-t1x9gknd 10368 18 the the DT cord-010119-t1x9gknd 10368 19 tubing tubing NN cord-010119-t1x9gknd 10368 20 is be VBZ cord-010119-t1x9gknd 10368 21 shorter short JJR cord-010119-t1x9gknd 10368 22 and and CC cord-010119-t1x9gknd 10368 23 it -PRON- PRP cord-010119-t1x9gknd 10368 24 meant mean VBD cord-010119-t1x9gknd 10368 25 being be VBG cord-010119-t1x9gknd 10368 26 more more RBR cord-010119-t1x9gknd 10368 27 difficult difficult JJ cord-010119-t1x9gknd 10368 28 when when WRB cord-010119-t1x9gknd 10368 29 manipulating manipulate VBG cord-010119-t1x9gknd 10368 30 the the DT cord-010119-t1x9gknd 10368 31 pools pool NNS cord-010119-t1x9gknd 10368 32 . . . cord-010119-t1x9gknd 10369 1 No no DT cord-010119-t1x9gknd 10369 2 issues issue NNS cord-010119-t1x9gknd 10369 3 should should MD cord-010119-t1x9gknd 10369 4 be be VB cord-010119-t1x9gknd 10369 5 found find VBN cord-010119-t1x9gknd 10369 6 if if IN cord-010119-t1x9gknd 10369 7 they -PRON- PRP cord-010119-t1x9gknd 10369 8 are be VBP cord-010119-t1x9gknd 10369 9 implemented implement VBN cord-010119-t1x9gknd 10369 10 in in IN cord-010119-t1x9gknd 10369 11 routine routine JJ cord-010119-t1x9gknd 10369 12 use use NN cord-010119-t1x9gknd 10369 13 . . . cord-010119-t1x9gknd 10370 1 It -PRON- PRP cord-010119-t1x9gknd 10370 2 's be VBZ cord-010119-t1x9gknd 10370 3 planned plan VBN cord-010119-t1x9gknd 10370 4 to to TO cord-010119-t1x9gknd 10370 5 start start VB cord-010119-t1x9gknd 10370 6 this this DT cord-010119-t1x9gknd 10370 7 implementation implementation NN cord-010119-t1x9gknd 10370 8 during during IN cord-010119-t1x9gknd 10370 9 this this DT cord-010119-t1x9gknd 10370 10 year year NN cord-010119-t1x9gknd 10370 11 , , , cord-010119-t1x9gknd 10370 12 2017 2017 CD cord-010119-t1x9gknd 10370 13 ; ; : cord-010119-t1x9gknd 10370 14 so so RB cord-010119-t1x9gknd 10370 15 then then RB cord-010119-t1x9gknd 10370 16 there there EX cord-010119-t1x9gknd 10370 17 will will MD cord-010119-t1x9gknd 10370 18 be be VB cord-010119-t1x9gknd 10370 19 larger large JJR cord-010119-t1x9gknd 10370 20 results result NNS cord-010119-t1x9gknd 10370 21 in in IN cord-010119-t1x9gknd 10370 22 order order NN cord-010119-t1x9gknd 10370 23 to to TO cord-010119-t1x9gknd 10370 24 have have VB cord-010119-t1x9gknd 10370 25 a a DT cord-010119-t1x9gknd 10370 26 proper proper JJ cord-010119-t1x9gknd 10370 27 procedure procedure NN cord-010119-t1x9gknd 10370 28 qualification qualification NN cord-010119-t1x9gknd 10370 29 . . . cord-010119-t1x9gknd 10371 1 Conclusion conclusion NN cord-010119-t1x9gknd 10371 2 : : : cord-010119-t1x9gknd 10371 3 Patients patient NNS cord-010119-t1x9gknd 10371 4 requiring require VBG cord-010119-t1x9gknd 10371 5 rare rare JJ cord-010119-t1x9gknd 10371 6 blood blood NN cord-010119-t1x9gknd 10371 7 products product NNS cord-010119-t1x9gknd 10371 8 are be VBP cord-010119-t1x9gknd 10371 9 rare rare JJ cord-010119-t1x9gknd 10371 10 , , , cord-010119-t1x9gknd 10371 11 and and CC cord-010119-t1x9gknd 10371 12 those those DT cord-010119-t1x9gknd 10371 13 lacking lack VBG cord-010119-t1x9gknd 10371 14 high high JJ cord-010119-t1x9gknd 10371 15 prevalence prevalence NN cord-010119-t1x9gknd 10371 16 antigens antigen NNS cord-010119-t1x9gknd 10371 17 are be VBP cord-010119-t1x9gknd 10371 18 the the DT cord-010119-t1x9gknd 10371 19 most most RBS cord-010119-t1x9gknd 10371 20 challenging challenging JJ cord-010119-t1x9gknd 10371 21 for for IN cord-010119-t1x9gknd 10371 22 whom whom WP cord-010119-t1x9gknd 10371 23 to to TO cord-010119-t1x9gknd 10371 24 obtain obtain VB cord-010119-t1x9gknd 10371 25 antigen antigen NN cord-010119-t1x9gknd 10371 26 negative negative JJ cord-010119-t1x9gknd 10371 27 blood blood NN cord-010119-t1x9gknd 10371 28 . . . cord-010119-t1x9gknd 10372 1 It -PRON- PRP cord-010119-t1x9gknd 10372 2 is be VBZ cord-010119-t1x9gknd 10372 3 clear clear JJ cord-010119-t1x9gknd 10372 4 that that IN cord-010119-t1x9gknd 10372 5 some some DT cord-010119-t1x9gknd 10372 6 requests request NNS cord-010119-t1x9gknd 10372 7 for for IN cord-010119-t1x9gknd 10372 8 exquisitely exquisitely RB cord-010119-t1x9gknd 10372 9 rare rare JJ cord-010119-t1x9gknd 10372 10 types type NNS cord-010119-t1x9gknd 10372 11 are be VBP cord-010119-t1x9gknd 10372 12 not not RB cord-010119-t1x9gknd 10372 13 able able JJ cord-010119-t1x9gknd 10372 14 to to TO cord-010119-t1x9gknd 10372 15 be be VB cord-010119-t1x9gknd 10372 16 filled fill VBN cord-010119-t1x9gknd 10372 17 with with IN cord-010119-t1x9gknd 10372 18 current current JJ cord-010119-t1x9gknd 10372 19 donors donor NNS cord-010119-t1x9gknd 10372 20 . . . cord-010119-t1x9gknd 10373 1 Molecular molecular JJ cord-010119-t1x9gknd 10373 2 testing testing NN cord-010119-t1x9gknd 10373 3 of of IN cord-010119-t1x9gknd 10373 4 large large JJ cord-010119-t1x9gknd 10373 5 numbers number NNS cord-010119-t1x9gknd 10373 6 of of IN cord-010119-t1x9gknd 10373 7 donors donor NNS cord-010119-t1x9gknd 10373 8 has have VBZ cord-010119-t1x9gknd 10373 9 likely likely RB cord-010119-t1x9gknd 10373 10 helped help VBN cord-010119-t1x9gknd 10373 11 to to TO cord-010119-t1x9gknd 10373 12 identify identify VB cord-010119-t1x9gknd 10373 13 more more JJR cord-010119-t1x9gknd 10373 14 rare rare JJ cord-010119-t1x9gknd 10373 15 donors donor NNS cord-010119-t1x9gknd 10373 16 in in IN cord-010119-t1x9gknd 10373 17 recent recent JJ cord-010119-t1x9gknd 10373 18 years year NNS cord-010119-t1x9gknd 10373 19 . . . cord-010119-t1x9gknd 10374 1 It -PRON- PRP cord-010119-t1x9gknd 10374 2 is be VBZ cord-010119-t1x9gknd 10374 3 recognized recognize VBN cord-010119-t1x9gknd 10374 4 that that IN cord-010119-t1x9gknd 10374 5 commercial commercial JJ cord-010119-t1x9gknd 10374 6 platforms platform NNS cord-010119-t1x9gknd 10374 7 do do VBP cord-010119-t1x9gknd 10374 8 not not RB cord-010119-t1x9gknd 10374 9 include include VB cord-010119-t1x9gknd 10374 10 many many JJ cord-010119-t1x9gknd 10374 11 of of IN cord-010119-t1x9gknd 10374 12 these these DT cord-010119-t1x9gknd 10374 13 making make VBG cord-010119-t1x9gknd 10374 14 these these DT cord-010119-t1x9gknd 10374 15 rare rare JJ cord-010119-t1x9gknd 10374 16 types type NNS cord-010119-t1x9gknd 10374 17 even even RB cord-010119-t1x9gknd 10374 18 more more RBR cord-010119-t1x9gknd 10374 19 challenging challenging JJ cord-010119-t1x9gknd 10374 20 to to TO cord-010119-t1x9gknd 10374 21 find find VB cord-010119-t1x9gknd 10374 22 . . . cord-010119-t1x9gknd 10375 1 Consideration consideration NN cord-010119-t1x9gknd 10375 2 should should MD cord-010119-t1x9gknd 10375 3 be be VB cord-010119-t1x9gknd 10375 4 given give VBN cord-010119-t1x9gknd 10375 5 to to IN cord-010119-t1x9gknd 10375 6 testing test VBG cord-010119-t1x9gknd 10375 7 more more JJR cord-010119-t1x9gknd 10375 8 donors donor NNS cord-010119-t1x9gknd 10375 9 of of IN cord-010119-t1x9gknd 10375 10 all all DT cord-010119-t1x9gknd 10375 11 ethnicities ethnicity NNS cord-010119-t1x9gknd 10375 12 to to TO cord-010119-t1x9gknd 10375 13 identify identify VB cord-010119-t1x9gknd 10375 14 more more JJR cord-010119-t1x9gknd 10375 15 rare rare JJ cord-010119-t1x9gknd 10375 16 donors donor NNS cord-010119-t1x9gknd 10375 17 . . . cord-010119-t1x9gknd 10376 1 Recommendation recommendation NN cord-010119-t1x9gknd 10376 2 # # NN cord-010119-t1x9gknd 10376 3 1 1 CD cord-010119-t1x9gknd 10376 4 : : : cord-010119-t1x9gknd 10376 5 Updating update VBG cord-010119-t1x9gknd 10376 6 donor donor NN cord-010119-t1x9gknd 10376 7 educational educational JJ cord-010119-t1x9gknd 10376 8 material material NN cord-010119-t1x9gknd 10376 9 to to TO cord-010119-t1x9gknd 10376 10 provide provide VB cord-010119-t1x9gknd 10376 11 more more RBR cord-010119-t1x9gknd 10376 12 comprehensive comprehensive JJ cord-010119-t1x9gknd 10376 13 information information NN cord-010119-t1x9gknd 10376 14 on on IN cord-010119-t1x9gknd 10376 15 risks risk NNS cord-010119-t1x9gknd 10376 16 of of IN cord-010119-t1x9gknd 10376 17 iron iron NN cord-010119-t1x9gknd 10376 18 deficiency deficiency NN cord-010119-t1x9gknd 10376 19 and and CC cord-010119-t1x9gknd 10376 20 recommendations recommendation NNS cord-010119-t1x9gknd 10376 21 on on IN cord-010119-t1x9gknd 10376 22 iron iron NN cord-010119-t1x9gknd 10376 23 supplementation supplementation NN cord-010119-t1x9gknd 10376 24 . . . cord-010119-t1x9gknd 10377 1 Updating update VBG cord-010119-t1x9gknd 10377 2 our -PRON- PRP$ cord-010119-t1x9gknd 10377 3 educational educational JJ cord-010119-t1x9gknd 10377 4 materials material NNS cord-010119-t1x9gknd 10377 5 will will MD cord-010119-t1x9gknd 10377 6 likely likely RB cord-010119-t1x9gknd 10377 7 have have VB cord-010119-t1x9gknd 10377 8 a a DT cord-010119-t1x9gknd 10377 9 minor minor JJ cord-010119-t1x9gknd 10377 10 impact impact NN cord-010119-t1x9gknd 10377 11 . . . cord-010119-t1x9gknd 10378 1 Recommendation recommendation NN cord-010119-t1x9gknd 10378 2 # # NN cord-010119-t1x9gknd 10378 3 2 2 CD cord-010119-t1x9gknd 10378 4 : : : cord-010119-t1x9gknd 10378 5 Implementing implementing NN cord-010119-t1x9gknd 10378 6 strategies strategy NNS cord-010119-t1x9gknd 10378 7 such such JJ cord-010119-t1x9gknd 10378 8 as as IN cord-010119-t1x9gknd 10378 9 iron iron NN cord-010119-t1x9gknd 10378 10 supplementation supplementation NN cord-010119-t1x9gknd 10378 11 , , , cord-010119-t1x9gknd 10378 12 ferritin ferritin NN cord-010119-t1x9gknd 10378 13 testing testing NN cord-010119-t1x9gknd 10378 14 or or CC cord-010119-t1x9gknd 10378 15 increasing increase VBG cord-010119-t1x9gknd 10378 16 interdonation interdonation NN cord-010119-t1x9gknd 10378 17 intervals interval NNS cord-010119-t1x9gknd 10378 18 for for IN cord-010119-t1x9gknd 10378 19 all all DT cord-010119-t1x9gknd 10378 20 donors donor NNS cord-010119-t1x9gknd 10378 21 or or CC cord-010119-t1x9gknd 10378 22 those those DT cord-010119-t1x9gknd 10378 23 groups group NNS cord-010119-t1x9gknd 10378 24 most most RBS cord-010119-t1x9gknd 10378 25 at at IN cord-010119-t1x9gknd 10378 26 risk risk NN cord-010119-t1x9gknd 10378 27 for for IN cord-010119-t1x9gknd 10378 28 iron iron NN cord-010119-t1x9gknd 10378 29 deficiency deficiency NN cord-010119-t1x9gknd 10378 30 . . . cord-010119-t1x9gknd 10379 1 Initial initial JJ cord-010119-t1x9gknd 10379 2 implementation implementation NN cord-010119-t1x9gknd 10379 3 would would MD cord-010119-t1x9gknd 10379 4 likely likely RB cord-010119-t1x9gknd 10379 5 be be VB cord-010119-t1x9gknd 10379 6 either either CC cord-010119-t1x9gknd 10379 7 iron iron NN cord-010119-t1x9gknd 10379 8 supplementation supplementation NN cord-010119-t1x9gknd 10379 9 or or CC cord-010119-t1x9gknd 10379 10 ferritin ferritin NN cord-010119-t1x9gknd 10379 11 testing testing NN cord-010119-t1x9gknd 10379 12 for for IN cord-010119-t1x9gknd 10379 13 at at IN cord-010119-t1x9gknd 10379 14 risk risk NN cord-010119-t1x9gknd 10379 15 groups group NNS cord-010119-t1x9gknd 10379 16 only only RB cord-010119-t1x9gknd 10379 17 and and CC cord-010119-t1x9gknd 10379 18 implementation implementation NN cord-010119-t1x9gknd 10379 19 of of IN cord-010119-t1x9gknd 10379 20 either either DT cord-010119-t1x9gknd 10379 21 one one CD cord-010119-t1x9gknd 10379 22 of of IN cord-010119-t1x9gknd 10379 23 these these DT cord-010119-t1x9gknd 10379 24 strategies strategy NNS cord-010119-t1x9gknd 10379 25 would would MD cord-010119-t1x9gknd 10379 26 potentially potentially RB cord-010119-t1x9gknd 10379 27 affect affect VB cord-010119-t1x9gknd 10379 28 over over IN cord-010119-t1x9gknd 10379 29 120 120 CD cord-010119-t1x9gknd 10379 30 , , , cord-010119-t1x9gknd 10379 31 000 000 CD cord-010119-t1x9gknd 10379 32 donors donor NNS cord-010119-t1x9gknd 10379 33 . . . cord-010119-t1x9gknd 10380 1 The the DT cord-010119-t1x9gknd 10380 2 recommendation recommendation NN cord-010119-t1x9gknd 10380 3 to to TO cord-010119-t1x9gknd 10380 4 limit limit VB cord-010119-t1x9gknd 10380 5 the the DT cord-010119-t1x9gknd 10380 6 number number NN cord-010119-t1x9gknd 10380 7 of of IN cord-010119-t1x9gknd 10380 8 donations donation NNS cord-010119-t1x9gknd 10380 9 would would MD cord-010119-t1x9gknd 10380 10 have have VB cord-010119-t1x9gknd 10380 11 a a DT cord-010119-t1x9gknd 10380 12 substantial substantial JJ cord-010119-t1x9gknd 10380 13 impact impact NN cord-010119-t1x9gknd 10380 14 . . . cord-010119-t1x9gknd 10381 1 For for IN cord-010119-t1x9gknd 10381 2 this this DT cord-010119-t1x9gknd 10381 3 analysis analysis NN cord-010119-t1x9gknd 10381 4 , , , cord-010119-t1x9gknd 10381 5 the the DT cord-010119-t1x9gknd 10381 6 focus focus NN cord-010119-t1x9gknd 10381 7 was be VBD cord-010119-t1x9gknd 10381 8 on on IN cord-010119-t1x9gknd 10381 9 16 16 CD cord-010119-t1x9gknd 10381 10 - - SYM cord-010119-t1x9gknd 10381 11 18 18 CD cord-010119-t1x9gknd 10381 12 year year NN cord-010119-t1x9gknd 10381 13 olds old NNS cord-010119-t1x9gknd 10381 14 and and CC cord-010119-t1x9gknd 10381 15 premenopausal premenopausal JJ cord-010119-t1x9gknd 10381 16 women woman NNS cord-010119-t1x9gknd 10381 17 ( ( -LRB- cord-010119-t1x9gknd 10381 18 ages age NNS cord-010119-t1x9gknd 10381 19 19 19 CD cord-010119-t1x9gknd 10381 20 - - SYM cord-010119-t1x9gknd 10381 21 55 55 CD cord-010119-t1x9gknd 10381 22 ) ) -RRB- cord-010119-t1x9gknd 10381 23 donors donor NNS cord-010119-t1x9gknd 10381 24 . . . cord-010119-t1x9gknd 10382 1 On on IN cord-010119-t1x9gknd 10382 2 average average JJ cord-010119-t1x9gknd 10382 3 , , , cord-010119-t1x9gknd 10382 4 16 16 CD cord-010119-t1x9gknd 10382 5 - - SYM cord-010119-t1x9gknd 10382 6 18 18 CD cord-010119-t1x9gknd 10382 7 year year NN cord-010119-t1x9gknd 10382 8 olds old NNS cord-010119-t1x9gknd 10382 9 donate donate VBP cord-010119-t1x9gknd 10382 10 1.3 1.3 CD cord-010119-t1x9gknd 10382 11 times time NNS cord-010119-t1x9gknd 10382 12 a a DT cord-010119-t1x9gknd 10382 13 year year NN cord-010119-t1x9gknd 10382 14 and and CC cord-010119-t1x9gknd 10382 15 premenopausal premenopausal JJ cord-010119-t1x9gknd 10382 16 women woman NNS cord-010119-t1x9gknd 10382 17 donate donate VBP cord-010119-t1x9gknd 10382 18 1.49 1.49 CD cord-010119-t1x9gknd 10382 19 times time NNS cord-010119-t1x9gknd 10382 20 a a DT cord-010119-t1x9gknd 10382 21 year year NN cord-010119-t1x9gknd 10382 22 . . . cord-010119-t1x9gknd 10383 1 If if IN cord-010119-t1x9gknd 10383 2 both both DT cord-010119-t1x9gknd 10383 3 of of IN cord-010119-t1x9gknd 10383 4 these these DT cord-010119-t1x9gknd 10383 5 groups group NNS cord-010119-t1x9gknd 10383 6 were be VBD cord-010119-t1x9gknd 10383 7 limited limit VBN cord-010119-t1x9gknd 10383 8 to to IN cord-010119-t1x9gknd 10383 9 donating donate VBG cord-010119-t1x9gknd 10383 10 once once RB cord-010119-t1x9gknd 10383 11 a a DT cord-010119-t1x9gknd 10383 12 year year NN cord-010119-t1x9gknd 10383 13 , , , cord-010119-t1x9gknd 10383 14 a a DT cord-010119-t1x9gknd 10383 15 total total NN cord-010119-t1x9gknd 10383 16 of of IN cord-010119-t1x9gknd 10383 17 4,845 4,845 CD cord-010119-t1x9gknd 10383 18 donations donation NNS cord-010119-t1x9gknd 10383 19 from from IN cord-010119-t1x9gknd 10383 20 16 16 CD cord-010119-t1x9gknd 10383 21 - - SYM cord-010119-t1x9gknd 10383 22 18 18 CD cord-010119-t1x9gknd 10383 23 year year NN cord-010119-t1x9gknd 10383 24 olds old NNS cord-010119-t1x9gknd 10383 25 and and CC cord-010119-t1x9gknd 10383 26 9,272 9,272 CD cord-010119-t1x9gknd 10383 27 donations donation NNS cord-010119-t1x9gknd 10383 28 from from IN cord-010119-t1x9gknd 10383 29 premenopausal premenopausal JJ cord-010119-t1x9gknd 10383 30 donors donor NNS cord-010119-t1x9gknd 10383 31 would would MD cord-010119-t1x9gknd 10383 32 not not RB cord-010119-t1x9gknd 10383 33 be be VB cord-010119-t1x9gknd 10383 34 collected collect VBN cord-010119-t1x9gknd 10383 35 . . . cord-010119-t1x9gknd 10384 1 Conclusion conclusion NN cord-010119-t1x9gknd 10384 2 : : : cord-010119-t1x9gknd 10385 1 After after IN cord-010119-t1x9gknd 10385 2 analyzing analyze VBG cord-010119-t1x9gknd 10385 3 the the DT cord-010119-t1x9gknd 10385 4 impact impact NN cord-010119-t1x9gknd 10385 5 of of IN cord-010119-t1x9gknd 10385 6 the the DT cord-010119-t1x9gknd 10385 7 AABB AABB NNP cord-010119-t1x9gknd 10385 8 Association Association NNP cord-010119-t1x9gknd 10385 9 Bulletin Bulletin NNP cord-010119-t1x9gknd 10385 10 # # $ cord-010119-t1x9gknd 10385 11 17 17 CD cord-010119-t1x9gknd 10385 12 - - SYM cord-010119-t1x9gknd 10385 13 02 02 CD cord-010119-t1x9gknd 10385 14 , , , cord-010119-t1x9gknd 10385 15 the the DT cord-010119-t1x9gknd 10385 16 bulletin bulletin NN cord-010119-t1x9gknd 10385 17 will will MD cord-010119-t1x9gknd 10385 18 have have VB cord-010119-t1x9gknd 10385 19 a a DT cord-010119-t1x9gknd 10385 20 significant significant JJ cord-010119-t1x9gknd 10385 21 impact impact NN cord-010119-t1x9gknd 10385 22 on on IN cord-010119-t1x9gknd 10385 23 both both DT cord-010119-t1x9gknd 10385 24 donors donor NNS cord-010119-t1x9gknd 10385 25 and and CC cord-010119-t1x9gknd 10385 26 our -PRON- PRP$ cord-010119-t1x9gknd 10385 27 local local JJ cord-010119-t1x9gknd 10385 28 blood blood NN cord-010119-t1x9gknd 10385 29 supply supply NN cord-010119-t1x9gknd 10385 30 . . . cord-010119-t1x9gknd 10386 1 More More JJR cord-010119-t1x9gknd 10386 2 than than IN cord-010119-t1x9gknd 10386 3 half half NN cord-010119-t1x9gknd 10386 4 of of IN cord-010119-t1x9gknd 10386 5 donors donor NNS cord-010119-t1x9gknd 10386 6 would would MD cord-010119-t1x9gknd 10386 7 receive receive VB cord-010119-t1x9gknd 10386 8 either either DT cord-010119-t1x9gknd 10386 9 ferritin ferritin NN cord-010119-t1x9gknd 10386 10 testing testing NN cord-010119-t1x9gknd 10386 11 or or CC cord-010119-t1x9gknd 10386 12 iron iron NN cord-010119-t1x9gknd 10386 13 supplementation supplementation NN cord-010119-t1x9gknd 10386 14 . . . cord-010119-t1x9gknd 10387 1 If if IN cord-010119-t1x9gknd 10387 2 the the DT cord-010119-t1x9gknd 10387 3 only only JJ cord-010119-t1x9gknd 10387 4 measure measure NN cord-010119-t1x9gknd 10387 5 employed employ VBN cord-010119-t1x9gknd 10387 6 is be VBZ cord-010119-t1x9gknd 10387 7 limiting limit VBG cord-010119-t1x9gknd 10387 8 the the DT cord-010119-t1x9gknd 10387 9 number number NN cord-010119-t1x9gknd 10387 10 of of IN cord-010119-t1x9gknd 10387 11 times time NNS cord-010119-t1x9gknd 10387 12 a a DT cord-010119-t1x9gknd 10387 13 donor donor NN cord-010119-t1x9gknd 10387 14 could could MD cord-010119-t1x9gknd 10387 15 donate donate VB cord-010119-t1x9gknd 10387 16 for for IN cord-010119-t1x9gknd 10387 17 16 16 CD cord-010119-t1x9gknd 10387 18 - - SYM cord-010119-t1x9gknd 10387 19 18 18 CD cord-010119-t1x9gknd 10387 20 year year NN cord-010119-t1x9gknd 10387 21 olds old NNS cord-010119-t1x9gknd 10387 22 and and CC cord-010119-t1x9gknd 10387 23 premenopausal premenopausal JJ cord-010119-t1x9gknd 10387 24 women woman NNS cord-010119-t1x9gknd 10387 25 , , , cord-010119-t1x9gknd 10387 26 this this DT cord-010119-t1x9gknd 10387 27 recommendation recommendation NN cord-010119-t1x9gknd 10387 28 would would MD cord-010119-t1x9gknd 10387 29 have have VB cord-010119-t1x9gknd 10387 30 a a DT cord-010119-t1x9gknd 10387 31 substantial substantial JJ cord-010119-t1x9gknd 10387 32 impact impact NN cord-010119-t1x9gknd 10387 33 on on IN cord-010119-t1x9gknd 10387 34 our -PRON- PRP$ cord-010119-t1x9gknd 10387 35 ability ability NN cord-010119-t1x9gknd 10387 36 to to TO cord-010119-t1x9gknd 10387 37 provide provide VB cord-010119-t1x9gknd 10387 38 blood blood NN cord-010119-t1x9gknd 10387 39 products product NNS cord-010119-t1x9gknd 10387 40 to to IN cord-010119-t1x9gknd 10387 41 local local JJ cord-010119-t1x9gknd 10387 42 hospitals hospital NNS cord-010119-t1x9gknd 10387 43 . . . cord-010119-t1x9gknd 10388 1 Background Background NNP cord-010119-t1x9gknd 10388 2 / / SYM cord-010119-t1x9gknd 10388 3 Case Case NNP cord-010119-t1x9gknd 10388 4 Studies Studies NNPS cord-010119-t1x9gknd 10388 5 : : : cord-010119-t1x9gknd 10389 1 Transfusion transfusion NN cord-010119-t1x9gknd 10389 2 medicine medicine NN cord-010119-t1x9gknd 10389 3 knowledge knowledge NN cord-010119-t1x9gknd 10389 4 deficits deficit NNS cord-010119-t1x9gknd 10389 5 are be VBP cord-010119-t1x9gknd 10389 6 apparent apparent JJ cord-010119-t1x9gknd 10389 7 among among IN cord-010119-t1x9gknd 10389 8 medical medical JJ cord-010119-t1x9gknd 10389 9 students student NNS cord-010119-t1x9gknd 10389 10 , , , cord-010119-t1x9gknd 10389 11 residents resident NNS cord-010119-t1x9gknd 10389 12 and and CC cord-010119-t1x9gknd 10389 13 practicing practice VBG cord-010119-t1x9gknd 10389 14 physicians physician NNS cord-010119-t1x9gknd 10389 15 . . . cord-010119-t1x9gknd 10390 1 These these DT cord-010119-t1x9gknd 10390 2 deficiencies deficiency NNS cord-010119-t1x9gknd 10390 3 may may MD cord-010119-t1x9gknd 10390 4 be be VB cord-010119-t1x9gknd 10390 5 due due JJ cord-010119-t1x9gknd 10390 6 to to IN cord-010119-t1x9gknd 10390 7 the the DT cord-010119-t1x9gknd 10390 8 frequency frequency NN cord-010119-t1x9gknd 10390 9 and and CC cord-010119-t1x9gknd 10390 10 type type NN cord-010119-t1x9gknd 10390 11 of of IN cord-010119-t1x9gknd 10390 12 education education NN cord-010119-t1x9gknd 10390 13 . . . cord-010119-t1x9gknd 10391 1 The the DT cord-010119-t1x9gknd 10391 2 majority majority NN cord-010119-t1x9gknd 10391 3 of of IN cord-010119-t1x9gknd 10391 4 medical medical JJ cord-010119-t1x9gknd 10391 5 students student NNS cord-010119-t1x9gknd 10391 6 in in IN cord-010119-t1x9gknd 10391 7 the the DT cord-010119-t1x9gknd 10391 8 United United NNP cord-010119-t1x9gknd 10391 9 States States NNP cord-010119-t1x9gknd 10391 10 receive receive VBP cord-010119-t1x9gknd 10391 11 four four CD cord-010119-t1x9gknd 10391 12 or or CC cord-010119-t1x9gknd 10391 13 fewer few JJR cord-010119-t1x9gknd 10391 14 hours hour NNS cord-010119-t1x9gknd 10391 15 of of IN cord-010119-t1x9gknd 10391 16 transfusion transfusion NN cord-010119-t1x9gknd 10391 17 medicine medicine NN cord-010119-t1x9gknd 10391 18 education education NN cord-010119-t1x9gknd 10391 19 . . . cord-010119-t1x9gknd 10392 1 The the DT cord-010119-t1x9gknd 10392 2 Transfusion Transfusion NNP cord-010119-t1x9gknd 10392 3 Medicine Medicine NNP cord-010119-t1x9gknd 10392 4 Academic Academic NNP cord-010119-t1x9gknd 10392 5 Award Award NNP cord-010119-t1x9gknd 10392 6 Group Group NNP cord-010119-t1x9gknd 10392 7 published publish VBD cord-010119-t1x9gknd 10392 8 educational educational JJ cord-010119-t1x9gknd 10392 9 content content NN cord-010119-t1x9gknd 10392 10 guidelines guideline NNS cord-010119-t1x9gknd 10392 11 for for IN cord-010119-t1x9gknd 10392 12 medical medical JJ cord-010119-t1x9gknd 10392 13 school school NN cord-010119-t1x9gknd 10392 14 , , , cord-010119-t1x9gknd 10392 15 residency residency NN cord-010119-t1x9gknd 10392 16 and and CC cord-010119-t1x9gknd 10392 17 fellowships fellowship NNS cord-010119-t1x9gknd 10392 18 . . . cord-010119-t1x9gknd 10393 1 However however RB cord-010119-t1x9gknd 10393 2 , , , cord-010119-t1x9gknd 10393 3 the the DT cord-010119-t1x9gknd 10393 4 frequency frequency NN cord-010119-t1x9gknd 10393 5 and and CC cord-010119-t1x9gknd 10393 6 educational educational JJ cord-010119-t1x9gknd 10393 7 methods method NNS cord-010119-t1x9gknd 10393 8 remain remain VBP cord-010119-t1x9gknd 10393 9 poorly poorly RB cord-010119-t1x9gknd 10393 10 evaluated evaluate VBN cord-010119-t1x9gknd 10393 11 and and CC cord-010119-t1x9gknd 10393 12 with with IN cord-010119-t1x9gknd 10393 13 little little JJ cord-010119-t1x9gknd 10393 14 guidance guidance NN cord-010119-t1x9gknd 10393 15 . . . cord-010119-t1x9gknd 10394 1 We -PRON- PRP cord-010119-t1x9gknd 10394 2 investigated investigate VBD cord-010119-t1x9gknd 10394 3 the the DT cord-010119-t1x9gknd 10394 4 effects effect NNS cord-010119-t1x9gknd 10394 5 of of IN cord-010119-t1x9gknd 10394 6 different different JJ cord-010119-t1x9gknd 10394 7 educational educational JJ cord-010119-t1x9gknd 10394 8 techniques technique NNS cord-010119-t1x9gknd 10394 9 on on IN cord-010119-t1x9gknd 10394 10 transfusion transfusion NN cord-010119-t1x9gknd 10394 11 medicine medicine NN cord-010119-t1x9gknd 10394 12 knowledge knowledge NN cord-010119-t1x9gknd 10394 13 acquisition acquisition NN cord-010119-t1x9gknd 10394 14 in in IN cord-010119-t1x9gknd 10394 15 novice novice JJ cord-010119-t1x9gknd 10394 16 learners learner NNS cord-010119-t1x9gknd 10394 17 . . . cord-010119-t1x9gknd 10395 1 Study Study NNP cord-010119-t1x9gknd 10395 2 Design Design NNP cord-010119-t1x9gknd 10395 3 / / SYM cord-010119-t1x9gknd 10395 4 Method method NN cord-010119-t1x9gknd 10395 5 : : : cord-010119-t1x9gknd 10396 1 Three three CD cord-010119-t1x9gknd 10396 2 educational educational JJ cord-010119-t1x9gknd 10396 3 pathways pathway NNS cord-010119-t1x9gknd 10396 4 were be VBD cord-010119-t1x9gknd 10396 5 developed develop VBN cord-010119-t1x9gknd 10396 6 to to TO cord-010119-t1x9gknd 10396 7 teach teach VB cord-010119-t1x9gknd 10396 8 principles principle NNS cord-010119-t1x9gknd 10396 9 of of IN cord-010119-t1x9gknd 10396 10 transfusion transfusion NN cord-010119-t1x9gknd 10396 11 medicine medicine NN cord-010119-t1x9gknd 10396 12 while while IN cord-010119-t1x9gknd 10396 13 allowing allow VBG cord-010119-t1x9gknd 10396 14 learners learner NNS cord-010119-t1x9gknd 10396 15 to to TO cord-010119-t1x9gknd 10396 16 recognize recognize VB cord-010119-t1x9gknd 10396 17 problems problem NNS cord-010119-t1x9gknd 10396 18 and and CC cord-010119-t1x9gknd 10396 19 develop develop VB cord-010119-t1x9gknd 10396 20 solutions solution NNS cord-010119-t1x9gknd 10396 21 for for IN cord-010119-t1x9gknd 10396 22 transfusion transfusion NN cord-010119-t1x9gknd 10396 23 medicine medicine NN cord-010119-t1x9gknd 10396 24 complications complication NNS cord-010119-t1x9gknd 10396 25 . . . cord-010119-t1x9gknd 10397 1 The the DT cord-010119-t1x9gknd 10397 2 simulation simulation NN cord-010119-t1x9gknd 10397 3 group group NN cord-010119-t1x9gknd 10397 4 received receive VBD cord-010119-t1x9gknd 10397 5 all all DT cord-010119-t1x9gknd 10397 6 educational educational JJ cord-010119-t1x9gknd 10397 7 activities activity NNS cord-010119-t1x9gknd 10397 8 within within IN cord-010119-t1x9gknd 10397 9 a a DT cord-010119-t1x9gknd 10397 10 2.5 2.5 CD cord-010119-t1x9gknd 10397 11 hour hour NN cord-010119-t1x9gknd 10397 12 inperson inperson NNP cord-010119-t1x9gknd 10397 13 , , , cord-010119-t1x9gknd 10397 14 high high JJ cord-010119-t1x9gknd 10397 15 - - HYPH cord-010119-t1x9gknd 10397 16 fidelity fidelity NN cord-010119-t1x9gknd 10397 17 live live JJ cord-010119-t1x9gknd 10397 18 session session NN cord-010119-t1x9gknd 10397 19 . . . cord-010119-t1x9gknd 10398 1 The the DT cord-010119-t1x9gknd 10398 2 hybrid hybrid JJ cord-010119-t1x9gknd 10398 3 group group NN cord-010119-t1x9gknd 10398 4 received receive VBD cord-010119-t1x9gknd 10398 5 some some DT cord-010119-t1x9gknd 10398 6 educational educational JJ cord-010119-t1x9gknd 10398 7 component component NN cord-010119-t1x9gknd 10398 8 online online RB cord-010119-t1x9gknd 10398 9 and and CC cord-010119-t1x9gknd 10398 10 also also RB cord-010119-t1x9gknd 10398 11 attended attend VBD cord-010119-t1x9gknd 10398 12 an an DT cord-010119-t1x9gknd 10398 13 in in IN cord-010119-t1x9gknd 10398 14 - - HYPH cord-010119-t1x9gknd 10398 15 person person NN cord-010119-t1x9gknd 10398 16 high high JJ cord-010119-t1x9gknd 10398 17 - - HYPH cord-010119-t1x9gknd 10398 18 fidelity fidelity NN cord-010119-t1x9gknd 10398 19 simulation simulation NN cord-010119-t1x9gknd 10398 20 session session NN cord-010119-t1x9gknd 10398 21 . . . cord-010119-t1x9gknd 10399 1 The the DT cord-010119-t1x9gknd 10399 2 online online JJ cord-010119-t1x9gknd 10399 3 only only JJ cord-010119-t1x9gknd 10399 4 group group NN cord-010119-t1x9gknd 10399 5 received receive VBD cord-010119-t1x9gknd 10399 6 all all DT cord-010119-t1x9gknd 10399 7 educational educational JJ cord-010119-t1x9gknd 10399 8 materials material NNS cord-010119-t1x9gknd 10399 9 online online RB cord-010119-t1x9gknd 10399 10 , , , cord-010119-t1x9gknd 10399 11 including include VBG cord-010119-t1x9gknd 10399 12 a a DT cord-010119-t1x9gknd 10399 13 pre pre JJ cord-010119-t1x9gknd 10399 14 - - JJ cord-010119-t1x9gknd 10399 15 recorded record VBN cord-010119-t1x9gknd 10399 16 - - HYPH cord-010119-t1x9gknd 10399 17 video video NN cord-010119-t1x9gknd 10399 18 simulation simulation NN cord-010119-t1x9gknd 10399 19 session session NN cord-010119-t1x9gknd 10399 20 . . . cord-010119-t1x9gknd 10400 1 The the DT cord-010119-t1x9gknd 10400 2 learners learner NNS cord-010119-t1x9gknd 10400 3 were be VBD cord-010119-t1x9gknd 10400 4 second second JJ cord-010119-t1x9gknd 10400 5 year year NN cord-010119-t1x9gknd 10400 6 medical medical JJ cord-010119-t1x9gknd 10400 7 students student NNS cord-010119-t1x9gknd 10400 8 enrolled enrol VBD cord-010119-t1x9gknd 10400 9 at at IN cord-010119-t1x9gknd 10400 10 one one CD cord-010119-t1x9gknd 10400 11 institution institution NN cord-010119-t1x9gknd 10400 12 . . . cord-010119-t1x9gknd 10401 1 The the DT cord-010119-t1x9gknd 10401 2 same same JJ cord-010119-t1x9gknd 10401 3 faculty faculty NN cord-010119-t1x9gknd 10401 4 members member NNS cord-010119-t1x9gknd 10401 5 taught teach VBD cord-010119-t1x9gknd 10401 6 all all DT cord-010119-t1x9gknd 10401 7 live live JJ cord-010119-t1x9gknd 10401 8 sessions session NNS cord-010119-t1x9gknd 10401 9 and and CC cord-010119-t1x9gknd 10401 10 developed develop VBD cord-010119-t1x9gknd 10401 11 all all DT cord-010119-t1x9gknd 10401 12 online online JJ cord-010119-t1x9gknd 10401 13 materials material NNS cord-010119-t1x9gknd 10401 14 ensuring ensure VBG cord-010119-t1x9gknd 10401 15 the the DT cord-010119-t1x9gknd 10401 16 content content NN cord-010119-t1x9gknd 10401 17 was be VBD cord-010119-t1x9gknd 10401 18 the the DT cord-010119-t1x9gknd 10401 19 same same JJ cord-010119-t1x9gknd 10401 20 . . . cord-010119-t1x9gknd 10402 1 A a DT cord-010119-t1x9gknd 10402 2 pre pre JJ cord-010119-t1x9gknd 10402 3 - - JJ cord-010119-t1x9gknd 10402 4 and and CC cord-010119-t1x9gknd 10402 5 post post JJ cord-010119-t1x9gknd 10402 6 - - JJ cord-010119-t1x9gknd 10402 7 test test NN cord-010119-t1x9gknd 10402 8 was be VBD cord-010119-t1x9gknd 10402 9 created create VBN cord-010119-t1x9gknd 10402 10 to to TO cord-010119-t1x9gknd 10402 11 address address VB cord-010119-t1x9gknd 10402 12 blood blood NN cord-010119-t1x9gknd 10402 13 groups group NNS cord-010119-t1x9gknd 10402 14 , , , cord-010119-t1x9gknd 10402 15 blood blood NN cord-010119-t1x9gknd 10402 16 donation donation NN cord-010119-t1x9gknd 10402 17 , , , cord-010119-t1x9gknd 10402 18 blood blood NN cord-010119-t1x9gknd 10402 19 testing testing NN cord-010119-t1x9gknd 10402 20 , , , cord-010119-t1x9gknd 10402 21 blood blood NN cord-010119-t1x9gknd 10402 22 component component NN cord-010119-t1x9gknd 10402 23 indications indication NNS cord-010119-t1x9gknd 10402 24 and and CC cord-010119-t1x9gknd 10402 25 transfusion transfusion NN cord-010119-t1x9gknd 10402 26 complications complication NNS cord-010119-t1x9gknd 10402 27 . . . cord-010119-t1x9gknd 10403 1 The the DT cord-010119-t1x9gknd 10403 2 educational educational JJ cord-010119-t1x9gknd 10403 3 session session NN cord-010119-t1x9gknd 10403 4 was be VBD cord-010119-t1x9gknd 10403 5 evaluated evaluate VBN cord-010119-t1x9gknd 10403 6 by by IN cord-010119-t1x9gknd 10403 7 the the DT cord-010119-t1x9gknd 10403 8 Likert Likert NNP cord-010119-t1x9gknd 10403 9 scale scale NN cord-010119-t1x9gknd 10403 10 survey survey NN cord-010119-t1x9gknd 10403 11 which which WDT cord-010119-t1x9gknd 10403 12 ranges range VBZ cord-010119-t1x9gknd 10403 13 from from IN cord-010119-t1x9gknd 10403 14 zero zero CD cord-010119-t1x9gknd 10403 15 ( ( -LRB- cord-010119-t1x9gknd 10403 16 poor poor JJ cord-010119-t1x9gknd 10403 17 / / SYM cord-010119-t1x9gknd 10403 18 unsatisfactory unsatisfactory JJ cord-010119-t1x9gknd 10403 19 ) ) -RRB- cord-010119-t1x9gknd 10403 20 to to IN cord-010119-t1x9gknd 10403 21 five five CD cord-010119-t1x9gknd 10403 22 ( ( -LRB- cord-010119-t1x9gknd 10403 23 outstanding outstanding JJ cord-010119-t1x9gknd 10403 24 ) ) -RRB- cord-010119-t1x9gknd 10403 25 . . . cord-010119-t1x9gknd 10404 1 Results result NNS cord-010119-t1x9gknd 10404 2 / / SYM cord-010119-t1x9gknd 10404 3 Finding finding NN cord-010119-t1x9gknd 10404 4 : : : cord-010119-t1x9gknd 10405 1 97 97 CD cord-010119-t1x9gknd 10405 2 % % NN cord-010119-t1x9gknd 10405 3 ( ( -LRB- cord-010119-t1x9gknd 10405 4 101/104 101/104 NN cord-010119-t1x9gknd 10405 5 ) ) -RRB- cord-010119-t1x9gknd 10405 6 of of IN cord-010119-t1x9gknd 10405 7 the the DT cord-010119-t1x9gknd 10405 8 simulation simulation NN cord-010119-t1x9gknd 10405 9 group group NN cord-010119-t1x9gknd 10405 10 students student NNS cord-010119-t1x9gknd 10405 11 improved improve VBD cord-010119-t1x9gknd 10405 12 their -PRON- PRP$ cord-010119-t1x9gknd 10405 13 post post JJ cord-010119-t1x9gknd 10405 14 - - JJ cord-010119-t1x9gknd 10405 15 test test JJ cord-010119-t1x9gknd 10405 16 scores score NNS cord-010119-t1x9gknd 10405 17 and and CC cord-010119-t1x9gknd 10405 18 had have VBD cord-010119-t1x9gknd 10405 19 an an DT cord-010119-t1x9gknd 10405 20 average average JJ cord-010119-t1x9gknd 10405 21 Likert Likert NNP cord-010119-t1x9gknd 10405 22 scale scale NN cord-010119-t1x9gknd 10405 23 rating rating NN cord-010119-t1x9gknd 10405 24 of of IN cord-010119-t1x9gknd 10405 25 4.1 4.1 CD cord-010119-t1x9gknd 10405 26 ( ( -LRB- cord-010119-t1x9gknd 10405 27 very very RB cord-010119-t1x9gknd 10405 28 good good JJ cord-010119-t1x9gknd 10405 29 ) ) -RRB- cord-010119-t1x9gknd 10405 30 . . . cord-010119-t1x9gknd 10406 1 89 89 CD cord-010119-t1x9gknd 10406 2 % % NN cord-010119-t1x9gknd 10406 3 ( ( -LRB- cord-010119-t1x9gknd 10406 4 63/71 63/71 CD cord-010119-t1x9gknd 10406 5 ) ) -RRB- cord-010119-t1x9gknd 10406 6 of of IN cord-010119-t1x9gknd 10406 7 hybrid hybrid JJ cord-010119-t1x9gknd 10406 8 group group NN cord-010119-t1x9gknd 10406 9 students student NNS cord-010119-t1x9gknd 10406 10 improved improve VBD cord-010119-t1x9gknd 10406 11 their -PRON- PRP$ cord-010119-t1x9gknd 10406 12 post post JJ cord-010119-t1x9gknd 10406 13 - - JJ cord-010119-t1x9gknd 10406 14 test test JJ cord-010119-t1x9gknd 10406 15 scores score NNS cord-010119-t1x9gknd 10406 16 and and CC cord-010119-t1x9gknd 10406 17 had have VBD cord-010119-t1x9gknd 10406 18 an an DT cord-010119-t1x9gknd 10406 19 average average JJ cord-010119-t1x9gknd 10406 20 Likert Likert NNP cord-010119-t1x9gknd 10406 21 scale scale NN cord-010119-t1x9gknd 10406 22 rating rating NN cord-010119-t1x9gknd 10406 23 of of IN cord-010119-t1x9gknd 10406 24 4.2 4.2 CD cord-010119-t1x9gknd 10406 25 ( ( -LRB- cord-010119-t1x9gknd 10406 26 very very RB cord-010119-t1x9gknd 10406 27 good good JJ cord-010119-t1x9gknd 10406 28 ) ) -RRB- cord-010119-t1x9gknd 10406 29 . . . cord-010119-t1x9gknd 10407 1 89 89 CD cord-010119-t1x9gknd 10407 2 % % NN cord-010119-t1x9gknd 10407 3 ( ( -LRB- cord-010119-t1x9gknd 10407 4 90/101 90/101 CD cord-010119-t1x9gknd 10407 5 ) ) -RRB- cord-010119-t1x9gknd 10407 6 of of IN cord-010119-t1x9gknd 10407 7 online online JJ cord-010119-t1x9gknd 10407 8 only only JJ cord-010119-t1x9gknd 10407 9 students student NNS cord-010119-t1x9gknd 10407 10 improved improve VBD cord-010119-t1x9gknd 10407 11 their -PRON- PRP$ cord-010119-t1x9gknd 10407 12 post post JJ cord-010119-t1x9gknd 10407 13 - - JJ cord-010119-t1x9gknd 10407 14 test test JJ cord-010119-t1x9gknd 10407 15 scores score NNS cord-010119-t1x9gknd 10407 16 and and CC cord-010119-t1x9gknd 10407 17 had have VBD cord-010119-t1x9gknd 10407 18 an an DT cord-010119-t1x9gknd 10407 19 average average JJ cord-010119-t1x9gknd 10407 20 Likert Likert NNP cord-010119-t1x9gknd 10407 21 scale scale NN cord-010119-t1x9gknd 10407 22 rating rating NN cord-010119-t1x9gknd 10407 23 of of IN cord-010119-t1x9gknd 10407 24 3.0 3.0 CD cord-010119-t1x9gknd 10407 25 ( ( -LRB- cord-010119-t1x9gknd 10407 26 good good JJ cord-010119-t1x9gknd 10407 27 ) ) -RRB- cord-010119-t1x9gknd 10407 28 . . . cord-010119-t1x9gknd 10408 1 The the DT cord-010119-t1x9gknd 10408 2 average average JJ cord-010119-t1x9gknd 10408 3 changes change NNS cord-010119-t1x9gknd 10408 4 in in IN cord-010119-t1x9gknd 10408 5 scores score NNS cord-010119-t1x9gknd 10408 6 were be VBD cord-010119-t1x9gknd 10408 7 statistically statistically RB cord-010119-t1x9gknd 10408 8 significant significant JJ cord-010119-t1x9gknd 10408 9 within within IN cord-010119-t1x9gknd 10408 10 all all DT cord-010119-t1x9gknd 10408 11 training training NN cord-010119-t1x9gknd 10408 12 groups group NNS cord-010119-t1x9gknd 10408 13 ( ( -LRB- cord-010119-t1x9gknd 10408 14 p p IN cord-010119-t1x9gknd 10408 15 value value NN cord-010119-t1x9gknd 10408 16 < < XX cord-010119-t1x9gknd 10408 17 0.0001 0.0001 CD cord-010119-t1x9gknd 10408 18 ) ) -RRB- cord-010119-t1x9gknd 10408 19 . . . cord-010119-t1x9gknd 10409 1 Additionally additionally RB cord-010119-t1x9gknd 10409 2 , , , cord-010119-t1x9gknd 10409 3 the the DT cord-010119-t1x9gknd 10409 4 simulation simulation NN cord-010119-t1x9gknd 10409 5 group group NN cord-010119-t1x9gknd 10409 6 had have VBD cord-010119-t1x9gknd 10409 7 a a DT cord-010119-t1x9gknd 10409 8 larger large JJR cord-010119-t1x9gknd 10409 9 increase increase NN cord-010119-t1x9gknd 10409 10 in in IN cord-010119-t1x9gknd 10409 11 average average JJ cord-010119-t1x9gknd 10409 12 post post JJ cord-010119-t1x9gknd 10409 13 - - JJ cord-010119-t1x9gknd 10409 14 test test JJ cord-010119-t1x9gknd 10409 15 scores score NNS cord-010119-t1x9gknd 10409 16 when when WRB cord-010119-t1x9gknd 10409 17 compared compare VBN cord-010119-t1x9gknd 10409 18 to to IN cord-010119-t1x9gknd 10409 19 the the DT cord-010119-t1x9gknd 10409 20 online online JJ cord-010119-t1x9gknd 10409 21 only only JJ cord-010119-t1x9gknd 10409 22 group group NN cord-010119-t1x9gknd 10409 23 ( ( -LRB- cord-010119-t1x9gknd 10409 24 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 10409 25 ) ) -RRB- cord-010119-t1x9gknd 10409 26 and and CC cord-010119-t1x9gknd 10409 27 the the DT cord-010119-t1x9gknd 10409 28 hybrid hybrid JJ cord-010119-t1x9gknd 10409 29 group group NN cord-010119-t1x9gknd 10409 30 ( ( -LRB- cord-010119-t1x9gknd 10409 31 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 10409 32 ) ) -RRB- cord-010119-t1x9gknd 10409 33 . . . cord-010119-t1x9gknd 10410 1 Conclusion conclusion NN cord-010119-t1x9gknd 10410 2 : : : cord-010119-t1x9gknd 10411 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10411 2 study study NN cord-010119-t1x9gknd 10411 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 10411 4 that that IN cord-010119-t1x9gknd 10411 5 a a DT cord-010119-t1x9gknd 10411 6 faculty faculty NN cord-010119-t1x9gknd 10411 7 taught teach VBD cord-010119-t1x9gknd 10411 8 high high JJ cord-010119-t1x9gknd 10411 9 - - HYPH cord-010119-t1x9gknd 10411 10 fidelity fidelity NN cord-010119-t1x9gknd 10411 11 transfusion transfusion NN cord-010119-t1x9gknd 10411 12 medicine medicine NN cord-010119-t1x9gknd 10411 13 simulation simulation NN cord-010119-t1x9gknd 10411 14 curriculum curriculum NN cord-010119-t1x9gknd 10411 15 consisting consist VBG cord-010119-t1x9gknd 10411 16 of of IN cord-010119-t1x9gknd 10411 17 an an DT cord-010119-t1x9gknd 10411 18 in in IN cord-010119-t1x9gknd 10411 19 - - HYPH cord-010119-t1x9gknd 10411 20 person person NN cord-010119-t1x9gknd 10411 21 didactic didactic JJ cord-010119-t1x9gknd 10411 22 session session NN cord-010119-t1x9gknd 10411 23 and and CC cord-010119-t1x9gknd 10411 24 simulation simulation NN cord-010119-t1x9gknd 10411 25 session session NN cord-010119-t1x9gknd 10411 26 for for IN cord-010119-t1x9gknd 10411 27 second second JJ cord-010119-t1x9gknd 10411 28 year year NN cord-010119-t1x9gknd 10411 29 medical medical JJ cord-010119-t1x9gknd 10411 30 students student NNS cord-010119-t1x9gknd 10411 31 produces produce VBZ cord-010119-t1x9gknd 10411 32 greater great JJR cord-010119-t1x9gknd 10411 33 knowledge knowledge NN cord-010119-t1x9gknd 10411 34 acquisition acquisition NN cord-010119-t1x9gknd 10411 35 compared compare VBN cord-010119-t1x9gknd 10411 36 to to IN cord-010119-t1x9gknd 10411 37 an an DT cord-010119-t1x9gknd 10411 38 online online NN cord-010119-t1x9gknd 10411 39 only only JJ cord-010119-t1x9gknd 10411 40 or or CC cord-010119-t1x9gknd 10411 41 hybrid hybrid JJ cord-010119-t1x9gknd 10411 42 curriculum curriculum NN cord-010119-t1x9gknd 10411 43 . . . cord-010119-t1x9gknd 10412 1 The the DT cord-010119-t1x9gknd 10412 2 high high JJ cord-010119-t1x9gknd 10412 3 - - HYPH cord-010119-t1x9gknd 10412 4 fidelity fidelity NN cord-010119-t1x9gknd 10412 5 simulation simulation NN cord-010119-t1x9gknd 10412 6 curriculum curriculum NN cord-010119-t1x9gknd 10412 7 is be VBZ cord-010119-t1x9gknd 10412 8 also also RB cord-010119-t1x9gknd 10412 9 preferred prefer VBN cord-010119-t1x9gknd 10412 10 over over IN cord-010119-t1x9gknd 10412 11 the the DT cord-010119-t1x9gknd 10412 12 online online JJ cord-010119-t1x9gknd 10412 13 only only JJ cord-010119-t1x9gknd 10412 14 education education NN cord-010119-t1x9gknd 10412 15 as as IN cord-010119-t1x9gknd 10412 16 indicated indicate VBN cord-010119-t1x9gknd 10412 17 by by IN cord-010119-t1x9gknd 10412 18 the the DT cord-010119-t1x9gknd 10412 19 Likert Likert NNP cord-010119-t1x9gknd 10412 20 survey survey NN cord-010119-t1x9gknd 10412 21 results result NNS cord-010119-t1x9gknd 10412 22 . . . cord-010119-t1x9gknd 10413 1 Aaron Aaron NNP cord-010119-t1x9gknd 10413 2 J J NNP cord-010119-t1x9gknd 10413 3 Wyble Wyble NNP cord-010119-t1x9gknd 10413 4 * * NFP cord-010119-t1x9gknd 10413 5 , , , cord-010119-t1x9gknd 10413 6 Yeon Yeon NNP cord-010119-t1x9gknd 10413 7 Mi Mi NNP cord-010119-t1x9gknd 10413 8 Kim Kim NNP cord-010119-t1x9gknd 10413 9 and and CC cord-010119-t1x9gknd 10413 10 Barbara Barbara NNP cord-010119-t1x9gknd 10413 11 J J NNP cord-010119-t1x9gknd 10413 12 Bryant Bryant NNP cord-010119-t1x9gknd 10413 13 . . . cord-010119-t1x9gknd 10414 1 University University NNP cord-010119-t1x9gknd 10414 2 of of IN cord-010119-t1x9gknd 10414 3 Texas Texas NNP cord-010119-t1x9gknd 10414 4 Medical Medical NNP cord-010119-t1x9gknd 10414 5 Branch Branch NNP cord-010119-t1x9gknd 10414 6 Background Background NNP cord-010119-t1x9gknd 10414 7 / / SYM cord-010119-t1x9gknd 10414 8 Case Case NNP cord-010119-t1x9gknd 10414 9 Studies Studies NNPS cord-010119-t1x9gknd 10414 10 : : : cord-010119-t1x9gknd 10414 11 Diagnostic diagnostic JJ cord-010119-t1x9gknd 10414 12 management management NN cord-010119-t1x9gknd 10414 13 teams team NNS cord-010119-t1x9gknd 10414 14 ( ( -LRB- cord-010119-t1x9gknd 10414 15 DMTs DMTs NNP cord-010119-t1x9gknd 10414 16 ) ) -RRB- cord-010119-t1x9gknd 10414 17 are be VBP cord-010119-t1x9gknd 10414 18 an an DT cord-010119-t1x9gknd 10414 19 innovative innovative JJ cord-010119-t1x9gknd 10414 20 way way NN cord-010119-t1x9gknd 10414 21 to to TO cord-010119-t1x9gknd 10414 22 bridge bridge VB cord-010119-t1x9gknd 10414 23 the the DT cord-010119-t1x9gknd 10414 24 communication communication NN cord-010119-t1x9gknd 10414 25 gap gap NN cord-010119-t1x9gknd 10414 26 between between IN cord-010119-t1x9gknd 10414 27 the the DT cord-010119-t1x9gknd 10414 28 laboratory laboratory NN cord-010119-t1x9gknd 10414 29 and and CC cord-010119-t1x9gknd 10414 30 clinical clinical JJ cord-010119-t1x9gknd 10414 31 services service NNS cord-010119-t1x9gknd 10414 32 thereby thereby RB cord-010119-t1x9gknd 10414 33 facilitating facilitate VBG cord-010119-t1x9gknd 10414 34 the the DT cord-010119-t1x9gknd 10414 35 delivery delivery NN cord-010119-t1x9gknd 10414 36 of of IN cord-010119-t1x9gknd 10414 37 improved improved JJ cord-010119-t1x9gknd 10414 38 patient patient JJ cord-010119-t1x9gknd 10414 39 care care NN cord-010119-t1x9gknd 10414 40 . . . cord-010119-t1x9gknd 10415 1 DMTs dmt NNS cord-010119-t1x9gknd 10415 2 employ employ VBP cord-010119-t1x9gknd 10415 3 a a DT cord-010119-t1x9gknd 10415 4 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 10415 5 approach approach NN cord-010119-t1x9gknd 10415 6 which which WDT cord-010119-t1x9gknd 10415 7 integrates integrate VBZ cord-010119-t1x9gknd 10415 8 clinical clinical JJ cord-010119-t1x9gknd 10415 9 and and CC cord-010119-t1x9gknd 10415 10 laboratory laboratory NN cord-010119-t1x9gknd 10415 11 data datum NNS cord-010119-t1x9gknd 10415 12 into into IN cord-010119-t1x9gknd 10415 13 succinct succinct JJ cord-010119-t1x9gknd 10415 14 interpretations interpretation NNS cord-010119-t1x9gknd 10415 15 and and CC cord-010119-t1x9gknd 10415 16 recommendations recommendation NNS cord-010119-t1x9gknd 10415 17 . . . cord-010119-t1x9gknd 10416 1 The the DT cord-010119-t1x9gknd 10416 2 interpretations interpretation NNS cord-010119-t1x9gknd 10416 3 must must MD cord-010119-t1x9gknd 10416 4 be be VB cord-010119-t1x9gknd 10416 5 of of IN cord-010119-t1x9gknd 10416 6 moderate moderate JJ cord-010119-t1x9gknd 10416 7 to to IN cord-010119-t1x9gknd 10416 8 high high JJ cord-010119-t1x9gknd 10416 9 complexity complexity NN cord-010119-t1x9gknd 10416 10 in in IN cord-010119-t1x9gknd 10416 11 order order NN cord-010119-t1x9gknd 10416 12 to to TO cord-010119-t1x9gknd 10416 13 be be VB cord-010119-t1x9gknd 10416 14 clinically clinically RB cord-010119-t1x9gknd 10416 15 valuable valuable JJ cord-010119-t1x9gknd 10416 16 . . . cord-010119-t1x9gknd 10417 1 Recommendations recommendation NNS cord-010119-t1x9gknd 10417 2 are be VBP cord-010119-t1x9gknd 10417 3 made make VBN cord-010119-t1x9gknd 10417 4 regarding regard VBG cord-010119-t1x9gknd 10417 5 future future JJ cord-010119-t1x9gknd 10417 6 testing testing NN cord-010119-t1x9gknd 10417 7 , , , cord-010119-t1x9gknd 10417 8 timing timing NN cord-010119-t1x9gknd 10417 9 of of IN cord-010119-t1x9gknd 10417 10 testing testing NN cord-010119-t1x9gknd 10417 11 prior prior RB cord-010119-t1x9gknd 10417 12 to to IN cord-010119-t1x9gknd 10417 13 blood blood NN cord-010119-t1x9gknd 10417 14 component component NN cord-010119-t1x9gknd 10417 15 needs need NNS cord-010119-t1x9gknd 10417 16 , , , cord-010119-t1x9gknd 10417 17 and and CC cord-010119-t1x9gknd 10417 18 other other JJ cord-010119-t1x9gknd 10417 19 pertinent pertinent JJ cord-010119-t1x9gknd 10417 20 concerns concern NNS cord-010119-t1x9gknd 10417 21 to to TO cord-010119-t1x9gknd 10417 22 allow allow VB cord-010119-t1x9gknd 10417 23 for for IN cord-010119-t1x9gknd 10417 24 improved improved JJ cord-010119-t1x9gknd 10417 25 coordination coordination NN cord-010119-t1x9gknd 10417 26 of of IN cord-010119-t1x9gknd 10417 27 patient patient JJ cord-010119-t1x9gknd 10417 28 care care NN cord-010119-t1x9gknd 10417 29 . . . cord-010119-t1x9gknd 10418 1 The the DT cord-010119-t1x9gknd 10418 2 timeliness timeliness NN cord-010119-t1x9gknd 10418 3 of of IN cord-010119-t1x9gknd 10418 4 the the DT cord-010119-t1x9gknd 10418 5 DMT DMT NNP cord-010119-t1x9gknd 10418 6 reporting reporting NN cord-010119-t1x9gknd 10418 7 is be VBZ cord-010119-t1x9gknd 10418 8 vital vital JJ cord-010119-t1x9gknd 10418 9 to to IN cord-010119-t1x9gknd 10418 10 patient patient JJ cord-010119-t1x9gknd 10418 11 management management NN cord-010119-t1x9gknd 10418 12 . . . cord-010119-t1x9gknd 10419 1 The the DT cord-010119-t1x9gknd 10419 2 inherent inherent JJ cord-010119-t1x9gknd 10419 3 design design NN cord-010119-t1x9gknd 10419 4 of of IN cord-010119-t1x9gknd 10419 5 a a DT cord-010119-t1x9gknd 10419 6 DMT DMT NNP cord-010119-t1x9gknd 10419 7 also also RB cord-010119-t1x9gknd 10419 8 provides provide VBZ cord-010119-t1x9gknd 10419 9 an an DT cord-010119-t1x9gknd 10419 10 educational educational JJ cord-010119-t1x9gknd 10419 11 opportunity opportunity NN cord-010119-t1x9gknd 10419 12 for for IN cord-010119-t1x9gknd 10419 13 trainees trainee NNS cord-010119-t1x9gknd 10419 14 at at IN cord-010119-t1x9gknd 10419 15 academic academic JJ cord-010119-t1x9gknd 10419 16 centers center NNS cord-010119-t1x9gknd 10419 17 . . . cord-010119-t1x9gknd 10420 1 Study Study NNP cord-010119-t1x9gknd 10420 2 Design Design NNP cord-010119-t1x9gknd 10420 3 / / SYM cord-010119-t1x9gknd 10420 4 Method method NN cord-010119-t1x9gknd 10420 5 : : : cord-010119-t1x9gknd 10421 1 The the DT cord-010119-t1x9gknd 10421 2 transfusion transfusion NN cord-010119-t1x9gknd 10421 3 medicine medicine NN cord-010119-t1x9gknd 10421 4 service service NN cord-010119-t1x9gknd 10421 5 at at IN cord-010119-t1x9gknd 10421 6 a a DT cord-010119-t1x9gknd 10421 7 large large JJ cord-010119-t1x9gknd 10421 8 university university NN cord-010119-t1x9gknd 10421 9 - - HYPH cord-010119-t1x9gknd 10421 10 based base VBN cord-010119-t1x9gknd 10421 11 academic academic JJ cord-010119-t1x9gknd 10421 12 medical medical JJ cord-010119-t1x9gknd 10421 13 center center NN cord-010119-t1x9gknd 10421 14 implemented implement VBD cord-010119-t1x9gknd 10421 15 a a DT cord-010119-t1x9gknd 10421 16 DMT DMT NNP cord-010119-t1x9gknd 10421 17 in in IN cord-010119-t1x9gknd 10421 18 2016 2016 CD cord-010119-t1x9gknd 10421 19 . . . cord-010119-t1x9gknd 10422 1 All all DT cord-010119-t1x9gknd 10422 2 cases case NNS cord-010119-t1x9gknd 10422 3 involving involve VBG cord-010119-t1x9gknd 10422 4 complex complex JJ cord-010119-t1x9gknd 10422 5 antibody antibody NN cord-010119-t1x9gknd 10422 6 identification identification NN cord-010119-t1x9gknd 10422 7 workups workup NNS cord-010119-t1x9gknd 10422 8 , , , cord-010119-t1x9gknd 10422 9 transfusion transfusion NN cord-010119-t1x9gknd 10422 10 reactions reaction NNS cord-010119-t1x9gknd 10422 11 , , , cord-010119-t1x9gknd 10422 12 deviations deviation NNS cord-010119-t1x9gknd 10422 13 from from IN cord-010119-t1x9gknd 10422 14 standard standard JJ cord-010119-t1x9gknd 10422 15 operating operating NN cord-010119-t1x9gknd 10422 16 procedures procedure NNS cord-010119-t1x9gknd 10422 17 , , , cord-010119-t1x9gknd 10422 18 consultations consultation NNS cord-010119-t1x9gknd 10422 19 for for IN cord-010119-t1x9gknd 10422 20 blood blood NN cord-010119-t1x9gknd 10422 21 component component NN cord-010119-t1x9gknd 10422 22 utilization utilization NN cord-010119-t1x9gknd 10422 23 , , , cord-010119-t1x9gknd 10422 24 and and CC cord-010119-t1x9gknd 10422 25 massive massive JJ cord-010119-t1x9gknd 10422 26 transfusion transfusion NN cord-010119-t1x9gknd 10422 27 protocols protocol NNS cord-010119-t1x9gknd 10422 28 from from IN cord-010119-t1x9gknd 10422 29 July July NNP cord-010119-t1x9gknd 10422 30 2016 2016 CD cord-010119-t1x9gknd 10422 31 through through IN cord-010119-t1x9gknd 10422 32 January January NNP cord-010119-t1x9gknd 10422 33 2017 2017 CD cord-010119-t1x9gknd 10422 34 were be VBD cord-010119-t1x9gknd 10422 35 evaluated evaluate VBN cord-010119-t1x9gknd 10422 36 by by IN cord-010119-t1x9gknd 10422 37 transfusion transfusion NN cord-010119-t1x9gknd 10422 38 medicine medicine NN cord-010119-t1x9gknd 10422 39 residents resident NNS cord-010119-t1x9gknd 10422 40 . . . cord-010119-t1x9gknd 10423 1 The the DT cord-010119-t1x9gknd 10423 2 electronic electronic JJ cord-010119-t1x9gknd 10423 3 medical medical JJ cord-010119-t1x9gknd 10423 4 record record NN cord-010119-t1x9gknd 10423 5 ( ( -LRB- cord-010119-t1x9gknd 10423 6 EMR EMR NNP cord-010119-t1x9gknd 10423 7 ) ) -RRB- cord-010119-t1x9gknd 10423 8 of of IN cord-010119-t1x9gknd 10423 9 each each DT cord-010119-t1x9gknd 10423 10 patient patient NN cord-010119-t1x9gknd 10423 11 was be VBD cord-010119-t1x9gknd 10423 12 also also RB cord-010119-t1x9gknd 10423 13 reviewed review VBN cord-010119-t1x9gknd 10423 14 to to TO cord-010119-t1x9gknd 10423 15 determine determine VB cord-010119-t1x9gknd 10423 16 relevant relevant JJ cord-010119-t1x9gknd 10423 17 clinical clinical JJ cord-010119-t1x9gknd 10423 18 history history NN cord-010119-t1x9gknd 10423 19 . . . cord-010119-t1x9gknd 10424 1 All all DT cord-010119-t1x9gknd 10424 2 significant significant JJ cord-010119-t1x9gknd 10424 3 findings finding NNS cord-010119-t1x9gknd 10424 4 were be VBD cord-010119-t1x9gknd 10424 5 presented present VBN cord-010119-t1x9gknd 10424 6 at at IN cord-010119-t1x9gknd 10424 7 the the DT cord-010119-t1x9gknd 10424 8 Transfusion Transfusion NNP cord-010119-t1x9gknd 10424 9 Medicine Medicine NNP cord-010119-t1x9gknd 10424 10 DMT DMT NNP cord-010119-t1x9gknd 10424 11 conferences conference NNS cord-010119-t1x9gknd 10424 12 . . . cord-010119-t1x9gknd 10425 1 The the DT cord-010119-t1x9gknd 10425 2 DMT DMT NNP cord-010119-t1x9gknd 10425 3 was be VBD cord-010119-t1x9gknd 10425 4 comprised comprise VBN cord-010119-t1x9gknd 10425 5 of of IN cord-010119-t1x9gknd 10425 6 physicians physician NNS cord-010119-t1x9gknd 10425 7 from from IN cord-010119-t1x9gknd 10425 8 Transfusion Transfusion NNP cord-010119-t1x9gknd 10425 9 Medicine Medicine NNP cord-010119-t1x9gknd 10425 10 , , , cord-010119-t1x9gknd 10425 11 Hematology Hematology NNP cord-010119-t1x9gknd 10425 12 / / SYM cord-010119-t1x9gknd 10425 13 Oncology Oncology NNP cord-010119-t1x9gknd 10425 14 , , , cord-010119-t1x9gknd 10425 15 Anesthesiology Anesthesiology NNP cord-010119-t1x9gknd 10425 16 , , , cord-010119-t1x9gknd 10425 17 Transfusion Transfusion NNP cord-010119-t1x9gknd 10425 18 Service Service NNP cord-010119-t1x9gknd 10425 19 technical technical JJ cord-010119-t1x9gknd 10425 20 staff staff NN cord-010119-t1x9gknd 10425 21 as as RB cord-010119-t1x9gknd 10425 22 well well RB cord-010119-t1x9gknd 10425 23 as as IN cord-010119-t1x9gknd 10425 24 visiting visit VBG cord-010119-t1x9gknd 10425 25 clinical clinical JJ cord-010119-t1x9gknd 10425 26 staff staff NN cord-010119-t1x9gknd 10425 27 from from IN cord-010119-t1x9gknd 10425 28 Surgery Surgery NNP cord-010119-t1x9gknd 10425 29 , , , cord-010119-t1x9gknd 10425 30 Obstetrics Obstetrics NNP cord-010119-t1x9gknd 10425 31 and and CC cord-010119-t1x9gknd 10425 32 Gynecology Gynecology NNP cord-010119-t1x9gknd 10425 33 , , , cord-010119-t1x9gknd 10425 34 Transplant Transplant NNP cord-010119-t1x9gknd 10425 35 Services Services NNP cord-010119-t1x9gknd 10425 36 , , , cord-010119-t1x9gknd 10425 37 and and CC cord-010119-t1x9gknd 10425 38 Pediatrics Pediatrics NNP cord-010119-t1x9gknd 10425 39 . . . cord-010119-t1x9gknd 10426 1 The the DT cord-010119-t1x9gknd 10426 2 DMT DMT NNP cord-010119-t1x9gknd 10426 3 integrated integrate VBD cord-010119-t1x9gknd 10426 4 the the DT cord-010119-t1x9gknd 10426 5 clinical clinical JJ cord-010119-t1x9gknd 10426 6 and and CC cord-010119-t1x9gknd 10426 7 laboratory laboratory NN cord-010119-t1x9gknd 10426 8 data datum NNS cord-010119-t1x9gknd 10426 9 to to TO cord-010119-t1x9gknd 10426 10 formulate formulate VB cord-010119-t1x9gknd 10426 11 relevant relevant JJ cord-010119-t1x9gknd 10426 12 interpretations interpretation NNS cord-010119-t1x9gknd 10426 13 and and CC cord-010119-t1x9gknd 10426 14 recommendations recommendation NNS cord-010119-t1x9gknd 10426 15 . . . cord-010119-t1x9gknd 10427 1 The the DT cord-010119-t1x9gknd 10427 2 final final JJ cord-010119-t1x9gknd 10427 3 DMT DMT NNP cord-010119-t1x9gknd 10427 4 reports report NNS cord-010119-t1x9gknd 10427 5 were be VBD cord-010119-t1x9gknd 10427 6 placed place VBN cord-010119-t1x9gknd 10427 7 into into IN cord-010119-t1x9gknd 10427 8 the the DT cord-010119-t1x9gknd 10427 9 EMR EMR NNP cord-010119-t1x9gknd 10427 10 for for IN cord-010119-t1x9gknd 10427 11 access access NN cord-010119-t1x9gknd 10427 12 by by IN cord-010119-t1x9gknd 10427 13 health health NN cord-010119-t1x9gknd 10427 14 care care NN cord-010119-t1x9gknd 10427 15 providers provider NNS cord-010119-t1x9gknd 10427 16 . . . cord-010119-t1x9gknd 10428 1 Financial financial JJ cord-010119-t1x9gknd 10428 2 benefits benefit NNS cord-010119-t1x9gknd 10428 3 of of IN cord-010119-t1x9gknd 10428 4 a a DT cord-010119-t1x9gknd 10428 5 transfusion transfusion NN cord-010119-t1x9gknd 10428 6 medicine medicine NN cord-010119-t1x9gknd 10428 7 DMT DMT NNP cord-010119-t1x9gknd 10428 8 were be VBD cord-010119-t1x9gknd 10428 9 also also RB cord-010119-t1x9gknd 10428 10 evaluated evaluate VBN cord-010119-t1x9gknd 10428 11 . . . cord-010119-t1x9gknd 10429 1 Results result NNS cord-010119-t1x9gknd 10429 2 / / SYM cord-010119-t1x9gknd 10429 3 Finding finding NN cord-010119-t1x9gknd 10429 4 : : : cord-010119-t1x9gknd 10430 1 In in IN cord-010119-t1x9gknd 10430 2 a a DT cord-010119-t1x9gknd 10430 3 7-month 7-month NNP cord-010119-t1x9gknd 10430 4 period period NN cord-010119-t1x9gknd 10430 5 , , , cord-010119-t1x9gknd 10430 6 504 504 CD cord-010119-t1x9gknd 10430 7 cases case NNS cord-010119-t1x9gknd 10430 8 of of IN cord-010119-t1x9gknd 10430 9 complex complex JJ cord-010119-t1x9gknd 10430 10 antibody antibody NN cord-010119-t1x9gknd 10430 11 identification identification NN cord-010119-t1x9gknd 10430 12 workups workup NNS cord-010119-t1x9gknd 10430 13 ( ( -LRB- cord-010119-t1x9gknd 10430 14 65 65 CD cord-010119-t1x9gknd 10430 15 % % NN cord-010119-t1x9gknd 10430 16 ) ) -RRB- cord-010119-t1x9gknd 10430 17 , , , cord-010119-t1x9gknd 10430 18 transfusion transfusion NN cord-010119-t1x9gknd 10430 19 reactions reaction NNS cord-010119-t1x9gknd 10430 20 ( ( -LRB- cord-010119-t1x9gknd 10430 21 2 2 CD cord-010119-t1x9gknd 10430 22 % % NN cord-010119-t1x9gknd 10430 23 ) ) -RRB- cord-010119-t1x9gknd 10430 24 , , , cord-010119-t1x9gknd 10430 25 consultations consultation NNS cord-010119-t1x9gknd 10430 26 for for IN cord-010119-t1x9gknd 10430 27 blood blood NN cord-010119-t1x9gknd 10430 28 component component NN cord-010119-t1x9gknd 10430 29 utilization utilization NN cord-010119-t1x9gknd 10430 30 ( ( -LRB- cord-010119-t1x9gknd 10430 31 6 6 CD cord-010119-t1x9gknd 10430 32 % % NN cord-010119-t1x9gknd 10430 33 ) ) -RRB- cord-010119-t1x9gknd 10430 34 , , , cord-010119-t1x9gknd 10430 35 and and CC cord-010119-t1x9gknd 10430 36 deviations deviation NNS cord-010119-t1x9gknd 10430 37 from from IN cord-010119-t1x9gknd 10430 38 standard standard JJ cord-010119-t1x9gknd 10430 39 operating operating NN cord-010119-t1x9gknd 10430 40 procedures procedure NNS cord-010119-t1x9gknd 10430 41 and and CC cord-010119-t1x9gknd 10430 42 massive massive JJ cord-010119-t1x9gknd 10430 43 transfusion transfusion NN cord-010119-t1x9gknd 10430 44 protocols protocol NNS cord-010119-t1x9gknd 10430 45 ( ( -LRB- cord-010119-t1x9gknd 10430 46 27 27 CD cord-010119-t1x9gknd 10430 47 % % NN cord-010119-t1x9gknd 10430 48 ) ) -RRB- cord-010119-t1x9gknd 10430 49 were be VBD cord-010119-t1x9gknd 10430 50 presented present VBN cord-010119-t1x9gknd 10430 51 at at IN cord-010119-t1x9gknd 10430 52 the the DT cord-010119-t1x9gknd 10430 53 Transfusion Transfusion NNP cord-010119-t1x9gknd 10430 54 Medicine Medicine NNP cord-010119-t1x9gknd 10430 55 DMT DMT NNP cord-010119-t1x9gknd 10430 56 conferences conference NNS cord-010119-t1x9gknd 10430 57 . . . cord-010119-t1x9gknd 10431 1 The the DT cord-010119-t1x9gknd 10431 2 placement placement NN cord-010119-t1x9gknd 10431 3 of of IN cord-010119-t1x9gknd 10431 4 DMT DMT NNP cord-010119-t1x9gknd 10431 5 narratives narrative NNS cord-010119-t1x9gknd 10431 6 in in IN cord-010119-t1x9gknd 10431 7 the the DT cord-010119-t1x9gknd 10431 8 EMR EMR NNP cord-010119-t1x9gknd 10431 9 as as IN cord-010119-t1x9gknd 10431 10 progress progress NN cord-010119-t1x9gknd 10431 11 notes note NNS cord-010119-t1x9gknd 10431 12 and and CC cord-010119-t1x9gknd 10431 13 laboratory laboratory NN cord-010119-t1x9gknd 10431 14 reports report NNS cord-010119-t1x9gknd 10431 15 provided provide VBD cord-010119-t1x9gknd 10431 16 informative informative JJ cord-010119-t1x9gknd 10431 17 and and CC cord-010119-t1x9gknd 10431 18 timely timely JJ cord-010119-t1x9gknd 10431 19 communications communication NNS cord-010119-t1x9gknd 10431 20 . . . cord-010119-t1x9gknd 10432 1 Residents resident NNS cord-010119-t1x9gknd 10432 2 participating participate VBG cord-010119-t1x9gknd 10432 3 in in IN cord-010119-t1x9gknd 10432 4 DMTs dmt NNS cord-010119-t1x9gknd 10432 5 demonstrated demonstrate VBD cord-010119-t1x9gknd 10432 6 improved improved JJ cord-010119-t1x9gknd 10432 7 clinical clinical JJ cord-010119-t1x9gknd 10432 8 and and CC cord-010119-t1x9gknd 10432 9 laboratory laboratory NN cord-010119-t1x9gknd 10432 10 correlation correlation NN cord-010119-t1x9gknd 10432 11 skills skill NNS cord-010119-t1x9gknd 10432 12 . . . cord-010119-t1x9gknd 10433 1 As as IN cord-010119-t1x9gknd 10433 2 a a DT cord-010119-t1x9gknd 10433 3 result result NN cord-010119-t1x9gknd 10433 4 , , , cord-010119-t1x9gknd 10433 5 resident resident JJ cord-010119-t1x9gknd 10433 6 competency competency NN cord-010119-t1x9gknd 10433 7 in in IN cord-010119-t1x9gknd 10433 8 transfusion transfusion NN cord-010119-t1x9gknd 10433 9 medicine medicine NN cord-010119-t1x9gknd 10433 10 was be VBD cord-010119-t1x9gknd 10433 11 enhanced enhance VBN cord-010119-t1x9gknd 10433 12 . . . cord-010119-t1x9gknd 10434 1 Over over IN cord-010119-t1x9gknd 10434 2 $ $ $ cord-010119-t1x9gknd 10434 3 68,000 68,000 CD cord-010119-t1x9gknd 10434 4 of of IN cord-010119-t1x9gknd 10434 5 revenue revenue NN cord-010119-t1x9gknd 10434 6 was be VBD cord-010119-t1x9gknd 10434 7 generated generate VBN cord-010119-t1x9gknd 10434 8 utilizing utilize VBG cord-010119-t1x9gknd 10434 9 the the DT cord-010119-t1x9gknd 10434 10 standard standard JJ cord-010119-t1x9gknd 10434 11 professional professional JJ cord-010119-t1x9gknd 10434 12 component component NN cord-010119-t1x9gknd 10434 13 CPT CPT NNP cord-010119-t1x9gknd 10434 14 codes code NNS cord-010119-t1x9gknd 10434 15 . . . cord-010119-t1x9gknd 10435 1 Conclusion conclusion NN cord-010119-t1x9gknd 10435 2 : : : cord-010119-t1x9gknd 10435 3 DMTs dmt NNS cord-010119-t1x9gknd 10435 4 encompassing encompass VBG cord-010119-t1x9gknd 10435 5 multiple multiple JJ cord-010119-t1x9gknd 10435 6 aspects aspect NNS cord-010119-t1x9gknd 10435 7 of of IN cord-010119-t1x9gknd 10435 8 transfusion transfusion NN cord-010119-t1x9gknd 10435 9 medicine medicine NN cord-010119-t1x9gknd 10435 10 improved improve VBD cord-010119-t1x9gknd 10435 11 patient patient JJ cord-010119-t1x9gknd 10435 12 care care NN cord-010119-t1x9gknd 10435 13 through through IN cord-010119-t1x9gknd 10435 14 enhanced enhance VBN cord-010119-t1x9gknd 10435 15 communication communication NN cord-010119-t1x9gknd 10435 16 between between IN cord-010119-t1x9gknd 10435 17 laboratory laboratory NN cord-010119-t1x9gknd 10435 18 and and CC cord-010119-t1x9gknd 10435 19 clinical clinical JJ cord-010119-t1x9gknd 10435 20 services service NNS cord-010119-t1x9gknd 10435 21 . . . cord-010119-t1x9gknd 10436 1 Additional additional JJ cord-010119-t1x9gknd 10436 2 benefits benefit NNS cord-010119-t1x9gknd 10436 3 of of IN cord-010119-t1x9gknd 10436 4 a a DT cord-010119-t1x9gknd 10436 5 DMT DMT NNP cord-010119-t1x9gknd 10436 6 program program NN cord-010119-t1x9gknd 10436 7 include include VBP cord-010119-t1x9gknd 10436 8 resident resident NN cord-010119-t1x9gknd 10436 9 , , , cord-010119-t1x9gknd 10436 10 clinician clinician NN cord-010119-t1x9gknd 10436 11 , , , cord-010119-t1x9gknd 10436 12 and and CC cord-010119-t1x9gknd 10436 13 technical technical JJ cord-010119-t1x9gknd 10436 14 staff staff NN cord-010119-t1x9gknd 10436 15 education education NN cord-010119-t1x9gknd 10436 16 and and CC cord-010119-t1x9gknd 10436 17 the the DT cord-010119-t1x9gknd 10436 18 generation generation NN cord-010119-t1x9gknd 10436 19 of of IN cord-010119-t1x9gknd 10436 20 revenue revenue NN cord-010119-t1x9gknd 10436 21 for for IN cord-010119-t1x9gknd 10436 22 the the DT cord-010119-t1x9gknd 10436 23 institution institution NN cord-010119-t1x9gknd 10436 24 . . . cord-010119-t1x9gknd 10437 1 Streamlining streamline VBG cord-010119-t1x9gknd 10437 2 a a DT cord-010119-t1x9gknd 10437 3 Blood Blood NNP cord-010119-t1x9gknd 10437 4 Center Center NNP cord-010119-t1x9gknd 10437 5 and and CC cord-010119-t1x9gknd 10437 6 Hospital Hospital NNP cord-010119-t1x9gknd 10437 7 Transfusion Transfusion NNP cord-010119-t1x9gknd 10437 8 Service Service NNP cord-010119-t1x9gknd 10437 9 Supply Supply NNP cord-010119-t1x9gknd 10437 10 - - HYPH cord-010119-t1x9gknd 10437 11 Chain Chain NNP cord-010119-t1x9gknd 10437 12 with with IN cord-010119-t1x9gknd 10437 13 an an DT cord-010119-t1x9gknd 10437 14 Informatics Informatics NNP cord-010119-t1x9gknd 10437 15 Vendor Vendor NNP cord-010119-t1x9gknd 10437 16 - - HYPH cord-010119-t1x9gknd 10437 17 Managed Managed NNP cord-010119-t1x9gknd 10437 18 Inventory Inventory NNP cord-010119-t1x9gknd 10437 19 Solution Solution NNP cord-010119-t1x9gknd 10437 20 Hamilton Hamilton NNP cord-010119-t1x9gknd 10437 21 C. C. NNP cord-010119-t1x9gknd 10437 22 Tsang Tsang NNP cord-010119-t1x9gknd 10437 23 * * NFP cord-010119-t1x9gknd 10437 24 1 1 CD cord-010119-t1x9gknd 10437 25 , , , cord-010119-t1x9gknd 10437 26 David David NNP cord-010119-t1x9gknd 10437 27 Lancaster Lancaster NNP cord-010119-t1x9gknd 10437 28 2 2 CD cord-010119-t1x9gknd 10437 29 , , , cord-010119-t1x9gknd 10437 30 Dianne Dianne NNP cord-010119-t1x9gknd 10437 31 Geary Geary NNP cord-010119-t1x9gknd 10437 32 2 2 CD cord-010119-t1x9gknd 10437 33 , , , cord-010119-t1x9gknd 10437 34 Robert Robert NNP cord-010119-t1x9gknd 10437 35 Scott Scott NNP cord-010119-t1x9gknd 10437 36 1 1 CD cord-010119-t1x9gknd 10437 37 , , , cord-010119-t1x9gknd 10437 38 Anh Anh NNP cord-010119-t1x9gknd 10437 39 Thu Thu NNP cord-010119-t1x9gknd 10437 40 Nguyen Nguyen NNP cord-010119-t1x9gknd 10437 41 1 1 CD cord-010119-t1x9gknd 10437 42 , , , cord-010119-t1x9gknd 10437 43 Adam Adam NNP cord-010119-t1x9gknd 10437 44 Garcia Garcia NNP cord-010119-t1x9gknd 10437 45 2 2 CD cord-010119-t1x9gknd 10437 46 , , , cord-010119-t1x9gknd 10437 47 Raina Raina NNP cord-010119-t1x9gknd 10437 48 Shankar Shankar NNP cord-010119-t1x9gknd 10437 49 1 1 CD cord-010119-t1x9gknd 10437 50 , , , cord-010119-t1x9gknd 10437 51 Leslie Leslie NNP cord-010119-t1x9gknd 10437 52 Buchanan Buchanan NNP cord-010119-t1x9gknd 10437 53 1 1 CD cord-010119-t1x9gknd 10437 54 and and CC cord-010119-t1x9gknd 10437 55 Tho Tho NNP cord-010119-t1x9gknd 10437 56 Pham Pham NNP cord-010119-t1x9gknd 10437 57 2 2 CD cord-010119-t1x9gknd 10437 58 . . . cord-010119-t1x9gknd 10438 1 1 1 LS cord-010119-t1x9gknd 10439 1 Stanford Stanford NNP cord-010119-t1x9gknd 10439 2 Health Health NNP cord-010119-t1x9gknd 10439 3 Care Care NNP cord-010119-t1x9gknd 10439 4 , , , cord-010119-t1x9gknd 10439 5 2 2 CD cord-010119-t1x9gknd 10439 6 Stanford Stanford NNP cord-010119-t1x9gknd 10439 7 Blood Blood NNP cord-010119-t1x9gknd 10439 8 Center Center NNP cord-010119-t1x9gknd 10439 9 Background Background NNP cord-010119-t1x9gknd 10439 10 / / SYM cord-010119-t1x9gknd 10439 11 Case Case NNP cord-010119-t1x9gknd 10439 12 Studies Studies NNPS cord-010119-t1x9gknd 10439 13 : : : cord-010119-t1x9gknd 10440 1 Inventory inventory NN cord-010119-t1x9gknd 10440 2 management management NN cord-010119-t1x9gknd 10440 3 is be VBZ cord-010119-t1x9gknd 10440 4 both both CC cord-010119-t1x9gknd 10440 5 a a DT cord-010119-t1x9gknd 10440 6 major major JJ cord-010119-t1x9gknd 10440 7 challenge challenge NN cord-010119-t1x9gknd 10440 8 and and CC cord-010119-t1x9gknd 10440 9 an an DT cord-010119-t1x9gknd 10440 10 integral integral JJ cord-010119-t1x9gknd 10440 11 part part NN cord-010119-t1x9gknd 10440 12 of of IN cord-010119-t1x9gknd 10440 13 hospital hospital NN cord-010119-t1x9gknd 10440 14 transfusion transfusion NN cord-010119-t1x9gknd 10440 15 service service NN cord-010119-t1x9gknd 10440 16 ( ( -LRB- cord-010119-t1x9gknd 10440 17 HTS HTS NNP cord-010119-t1x9gknd 10440 18 ) ) -RRB- cord-010119-t1x9gknd 10440 19 and and CC cord-010119-t1x9gknd 10440 20 blood blood NN cord-010119-t1x9gknd 10440 21 centers center NNS cord-010119-t1x9gknd 10440 22 ( ( -LRB- cord-010119-t1x9gknd 10440 23 BC BC NNP cord-010119-t1x9gknd 10440 24 ) ) -RRB- cord-010119-t1x9gknd 10440 25 operations operation NNS cord-010119-t1x9gknd 10440 26 . . . cord-010119-t1x9gknd 10441 1 The the DT cord-010119-t1x9gknd 10441 2 current current JJ cord-010119-t1x9gknd 10441 3 process process NN cord-010119-t1x9gknd 10441 4 at at IN cord-010119-t1x9gknd 10441 5 our -PRON- PRP$ cord-010119-t1x9gknd 10441 6 institution institution NN cord-010119-t1x9gknd 10441 7 involves involve VBZ cord-010119-t1x9gknd 10441 8 twice twice RB cord-010119-t1x9gknd 10441 9 - - HYPH cord-010119-t1x9gknd 10441 10 per per IN cord-010119-t1x9gknd 10441 11 - - HYPH cord-010119-t1x9gknd 10441 12 day day NN cord-010119-t1x9gknd 10441 13 shipments shipment NNS cord-010119-t1x9gknd 10441 14 from from IN cord-010119-t1x9gknd 10441 15 the the DT cord-010119-t1x9gknd 10441 16 BC BC NNP cord-010119-t1x9gknd 10441 17 to to IN cord-010119-t1x9gknd 10441 18 the the DT cord-010119-t1x9gknd 10441 19 HTS HTS NNP cord-010119-t1x9gknd 10441 20 , , , cord-010119-t1x9gknd 10441 21 with with IN cord-010119-t1x9gknd 10441 22 each each DT cord-010119-t1x9gknd 10441 23 shipment shipment NN cord-010119-t1x9gknd 10441 24 predicated predicate VBN cord-010119-t1x9gknd 10441 25 upon upon IN cord-010119-t1x9gknd 10441 26 current current JJ cord-010119-t1x9gknd 10441 27 stock stock NN cord-010119-t1x9gknd 10441 28 levels level NNS cord-010119-t1x9gknd 10441 29 at at IN cord-010119-t1x9gknd 10441 30 HTS HTS NNP cord-010119-t1x9gknd 10441 31 . . . cord-010119-t1x9gknd 10442 1 Manually manually RB cord-010119-t1x9gknd 10442 2 obtaining obtain VBG cord-010119-t1x9gknd 10442 3 inventory inventory NN cord-010119-t1x9gknd 10442 4 levels level NNS cord-010119-t1x9gknd 10442 5 for for IN cord-010119-t1x9gknd 10442 6 each each DT cord-010119-t1x9gknd 10442 7 product product NN cord-010119-t1x9gknd 10442 8 is be VBZ cord-010119-t1x9gknd 10442 9 time time NN cord-010119-t1x9gknd 10442 10 - - HYPH cord-010119-t1x9gknd 10442 11 consuming consume VBG cord-010119-t1x9gknd 10442 12 . . . cord-010119-t1x9gknd 10443 1 The the DT cord-010119-t1x9gknd 10443 2 manual manual JJ cord-010119-t1x9gknd 10443 3 determination determination NN cord-010119-t1x9gknd 10443 4 is be VBZ cord-010119-t1x9gknd 10443 5 also also RB cord-010119-t1x9gknd 10443 6 errorprone errorprone VBN cord-010119-t1x9gknd 10443 7 . . . cord-010119-t1x9gknd 10444 1 We -PRON- PRP cord-010119-t1x9gknd 10444 2 aim aim VBP cord-010119-t1x9gknd 10444 3 to to TO cord-010119-t1x9gknd 10444 4 enhance enhance VB cord-010119-t1x9gknd 10444 5 inventory inventory NN cord-010119-t1x9gknd 10444 6 management management NN cord-010119-t1x9gknd 10444 7 operations operation NNS cord-010119-t1x9gknd 10444 8 by by IN cord-010119-t1x9gknd 10444 9 developing develop VBG cord-010119-t1x9gknd 10444 10 an an DT cord-010119-t1x9gknd 10444 11 informatics informatics NN cord-010119-t1x9gknd 10444 12 solution solution NN cord-010119-t1x9gknd 10444 13 to to IN cord-010119-t1x9gknd 10444 14 ( ( -LRB- cord-010119-t1x9gknd 10444 15 1 1 LS cord-010119-t1x9gknd 10444 16 ) ) -RRB- cord-010119-t1x9gknd 10444 17 streamline streamline VB cord-010119-t1x9gknd 10444 18 the the DT cord-010119-t1x9gknd 10444 19 ordering ordering NN cord-010119-t1x9gknd 10444 20 process process NN cord-010119-t1x9gknd 10444 21 to to TO cord-010119-t1x9gknd 10444 22 accurately accurately RB cord-010119-t1x9gknd 10444 23 reflect reflect VB cord-010119-t1x9gknd 10444 24 inventory inventory NN cord-010119-t1x9gknd 10444 25 status status NN cord-010119-t1x9gknd 10444 26 and and CC cord-010119-t1x9gknd 10444 27 transfusion transfusion NN cord-010119-t1x9gknd 10444 28 practices practice NNS cord-010119-t1x9gknd 10444 29 and and CC cord-010119-t1x9gknd 10444 30 ( ( -LRB- cord-010119-t1x9gknd 10444 31 2 2 LS cord-010119-t1x9gknd 10444 32 ) ) -RRB- cord-010119-t1x9gknd 10444 33 re re NNS cord-010119-t1x9gknd 10444 34 - - VB cord-010119-t1x9gknd 10444 35 allocate allocate VB cord-010119-t1x9gknd 10444 36 valuable valuable JJ cord-010119-t1x9gknd 10444 37 HTS HTS NNP cord-010119-t1x9gknd 10444 38 tech tech NN cord-010119-t1x9gknd 10444 39 time time NN cord-010119-t1x9gknd 10444 40 . . . cord-010119-t1x9gknd 10445 1 Study Study NNP cord-010119-t1x9gknd 10445 2 Design Design NNP cord-010119-t1x9gknd 10445 3 / / SYM cord-010119-t1x9gknd 10445 4 Method method NN cord-010119-t1x9gknd 10445 5 : : : cord-010119-t1x9gknd 10446 1 At at IN cord-010119-t1x9gknd 10446 2 our -PRON- PRP$ cord-010119-t1x9gknd 10446 3 HTS HTS NNP cord-010119-t1x9gknd 10446 4 , , , cord-010119-t1x9gknd 10446 5 the the DT cord-010119-t1x9gknd 10446 6 general general JJ cord-010119-t1x9gknd 10446 7 inventory inventory NN cord-010119-t1x9gknd 10446 8 accounts account VBZ cord-010119-t1x9gknd 10446 9 for for IN cord-010119-t1x9gknd 10446 10 over over IN cord-010119-t1x9gknd 10446 11 50 50 CD cord-010119-t1x9gknd 10446 12 product product NN cord-010119-t1x9gknd 10446 13 categories category NNS cord-010119-t1x9gknd 10446 14 broken break VBN cord-010119-t1x9gknd 10446 15 down down RP cord-010119-t1x9gknd 10446 16 by by IN cord-010119-t1x9gknd 10446 17 component component NN cord-010119-t1x9gknd 10446 18 , , , cord-010119-t1x9gknd 10446 19 blood blood NN cord-010119-t1x9gknd 10446 20 type type NN cord-010119-t1x9gknd 10446 21 , , , cord-010119-t1x9gknd 10446 22 irradiated irradiate VBN cord-010119-t1x9gknd 10446 23 status status NN cord-010119-t1x9gknd 10446 24 , , , cord-010119-t1x9gknd 10446 25 and and CC cord-010119-t1x9gknd 10446 26 CMV cmv NN cord-010119-t1x9gknd 10446 27 - - HYPH cord-010119-t1x9gknd 10446 28 serology serology NN cord-010119-t1x9gknd 10446 29 status status NN cord-010119-t1x9gknd 10446 30 . . . cord-010119-t1x9gknd 10447 1 We -PRON- PRP cord-010119-t1x9gknd 10447 2 therefore therefore RB cord-010119-t1x9gknd 10447 3 sought seek VBD cord-010119-t1x9gknd 10447 4 to to TO cord-010119-t1x9gknd 10447 5 establish establish VB cord-010119-t1x9gknd 10447 6 an an DT cord-010119-t1x9gknd 10447 7 electronic electronic JJ cord-010119-t1x9gknd 10447 8 method method NN cord-010119-t1x9gknd 10447 9 to to TO cord-010119-t1x9gknd 10447 10 reliably reliably RB cord-010119-t1x9gknd 10447 11 infer infer VB cord-010119-t1x9gknd 10447 12 the the DT cord-010119-t1x9gknd 10447 13 general general JJ cord-010119-t1x9gknd 10447 14 inventory inventory NN cord-010119-t1x9gknd 10447 15 level level NN cord-010119-t1x9gknd 10447 16 . . . cord-010119-t1x9gknd 10448 1 Since since IN cord-010119-t1x9gknd 10448 2 the the DT cord-010119-t1x9gknd 10448 3 raw raw JJ cord-010119-t1x9gknd 10448 4 electronic electronic JJ cord-010119-t1x9gknd 10448 5 inventory inventory NN cord-010119-t1x9gknd 10448 6 report report NN cord-010119-t1x9gknd 10448 7 comprised comprise VBD cord-010119-t1x9gknd 10448 8 both both CC cord-010119-t1x9gknd 10448 9 the the DT cord-010119-t1x9gknd 10448 10 general general JJ cord-010119-t1x9gknd 10448 11 inventory inventory NN cord-010119-t1x9gknd 10448 12 and and CC cord-010119-t1x9gknd 10448 13 physically physically RB cord-010119-t1x9gknd 10448 14 sequestered sequester VBN cord-010119-t1x9gknd 10448 15 units unit NNS cord-010119-t1x9gknd 10448 16 ( ( -LRB- cord-010119-t1x9gknd 10448 17 e.g. e.g. IN cord-010119-t1x9gknd 10448 18 special special JJ cord-010119-t1x9gknd 10448 19 antigen antigen NN cord-010119-t1x9gknd 10448 20 units unit NNS cord-010119-t1x9gknd 10448 21 , , , cord-010119-t1x9gknd 10448 22 cross cross NN cord-010119-t1x9gknd 10448 23 - - JJ cord-010119-t1x9gknd 10448 24 matched match VBN cord-010119-t1x9gknd 10448 25 units unit NNS cord-010119-t1x9gknd 10448 26 ) ) -RRB- cord-010119-t1x9gknd 10448 27 , , , cord-010119-t1x9gknd 10448 28 over over IN cord-010119-t1x9gknd 10448 29 a a DT cord-010119-t1x9gknd 10448 30 5-month 5-month CD cord-010119-t1x9gknd 10448 31 calibration calibration NN cord-010119-t1x9gknd 10448 32 period period NN cord-010119-t1x9gknd 10448 33 we -PRON- PRP cord-010119-t1x9gknd 10448 34 performed perform VBD cord-010119-t1x9gknd 10448 35 linear linear JJ cord-010119-t1x9gknd 10448 36 regression regression NN cord-010119-t1x9gknd 10448 37 between between IN cord-010119-t1x9gknd 10448 38 electronic electronic JJ cord-010119-t1x9gknd 10448 39 and and CC cord-010119-t1x9gknd 10448 40 the the DT cord-010119-t1x9gknd 10448 41 gold gold JJ cord-010119-t1x9gknd 10448 42 - - HYPH cord-010119-t1x9gknd 10448 43 standard standard NN cord-010119-t1x9gknd 10448 44 manual manual JJ cord-010119-t1x9gknd 10448 45 count count NN cord-010119-t1x9gknd 10448 46 to to TO cord-010119-t1x9gknd 10448 47 impute impute VB cord-010119-t1x9gknd 10448 48 from from IN cord-010119-t1x9gknd 10448 49 the the DT cord-010119-t1x9gknd 10448 50 electronic electronic JJ cord-010119-t1x9gknd 10448 51 census census NN cord-010119-t1x9gknd 10448 52 the the DT cord-010119-t1x9gknd 10448 53 number number NN cord-010119-t1x9gknd 10448 54 of of IN cord-010119-t1x9gknd 10448 55 units unit NNS cord-010119-t1x9gknd 10448 56 of of IN cord-010119-t1x9gknd 10448 57 each each DT cord-010119-t1x9gknd 10448 58 product product NN cord-010119-t1x9gknd 10448 59 category category NN cord-010119-t1x9gknd 10448 60 in in IN cord-010119-t1x9gknd 10448 61 the the DT cord-010119-t1x9gknd 10448 62 general general JJ cord-010119-t1x9gknd 10448 63 inventory inventory NN cord-010119-t1x9gknd 10448 64 . . . cord-010119-t1x9gknd 10449 1 Once once IN cord-010119-t1x9gknd 10449 2 we -PRON- PRP cord-010119-t1x9gknd 10449 3 had have VBD cord-010119-t1x9gknd 10449 4 a a DT cord-010119-t1x9gknd 10449 5 reliable reliable JJ cord-010119-t1x9gknd 10449 6 electronic electronic JJ cord-010119-t1x9gknd 10449 7 method method NN cord-010119-t1x9gknd 10449 8 to to TO cord-010119-t1x9gknd 10449 9 determine determine VB cord-010119-t1x9gknd 10449 10 inventory inventory NN cord-010119-t1x9gknd 10449 11 levels level NNS cord-010119-t1x9gknd 10449 12 , , , cord-010119-t1x9gknd 10449 13 we -PRON- PRP cord-010119-t1x9gknd 10449 14 implemented implement VBD cord-010119-t1x9gknd 10449 15 a a DT cord-010119-t1x9gknd 10449 16 3-month 3-month CD cord-010119-t1x9gknd 10449 17 pilot pilot NN cord-010119-t1x9gknd 10449 18 period period NN cord-010119-t1x9gknd 10449 19 . . . cord-010119-t1x9gknd 10450 1 We -PRON- PRP cord-010119-t1x9gknd 10450 2 analyzed analyze VBD cord-010119-t1x9gknd 10450 3 various various JJ cord-010119-t1x9gknd 10450 4 metrics metric NNS cord-010119-t1x9gknd 10450 5 pre pre VBP cord-010119-t1x9gknd 10450 6 and and CC cord-010119-t1x9gknd 10450 7 post post VB cord-010119-t1x9gknd 10450 8 pilot pilot NN cord-010119-t1x9gknd 10450 9 implementation implementation NN cord-010119-t1x9gknd 10450 10 to to TO cord-010119-t1x9gknd 10450 11 ensure ensure VB cord-010119-t1x9gknd 10450 12 non non JJ cord-010119-t1x9gknd 10450 13 - - JJ cord-010119-t1x9gknd 10450 14 inferiority inferiority NN cord-010119-t1x9gknd 10450 15 of of IN cord-010119-t1x9gknd 10450 16 our -PRON- PRP$ cord-010119-t1x9gknd 10450 17 electronic electronic JJ cord-010119-t1x9gknd 10450 18 system system NN cord-010119-t1x9gknd 10450 19 : : : cord-010119-t1x9gknd 10450 20 ( ( -LRB- cord-010119-t1x9gknd 10450 21 1 1 LS cord-010119-t1x9gknd 10450 22 ) ) -RRB- cord-010119-t1x9gknd 10450 23 the the DT cord-010119-t1x9gknd 10450 24 ratio ratio NN cord-010119-t1x9gknd 10450 25 of of IN cord-010119-t1x9gknd 10450 26 units unit NNS cord-010119-t1x9gknd 10450 27 transfused transfuse VBN cord-010119-t1x9gknd 10450 28 per per IN cord-010119-t1x9gknd 10450 29 week week NN cord-010119-t1x9gknd 10450 30 to to IN cord-010119-t1x9gknd 10450 31 the the DT cord-010119-t1x9gknd 10450 32 number number NN cord-010119-t1x9gknd 10450 33 stocked stock VBN cord-010119-t1x9gknd 10450 34 ( ( -LRB- cord-010119-t1x9gknd 10450 35 T t NN cord-010119-t1x9gknd 10450 36 : : : cord-010119-t1x9gknd 10450 37 S S NNP cord-010119-t1x9gknd 10450 38 ) ) -RRB- cord-010119-t1x9gknd 10450 39 , , , cord-010119-t1x9gknd 10450 40 ( ( -LRB- cord-010119-t1x9gknd 10450 41 2 2 LS cord-010119-t1x9gknd 10450 42 ) ) -RRB- cord-010119-t1x9gknd 10450 43 the the DT cord-010119-t1x9gknd 10450 44 number number NN cord-010119-t1x9gknd 10450 45 of of IN cord-010119-t1x9gknd 10450 46 products product NNS cord-010119-t1x9gknd 10450 47 ordered order VBN cord-010119-t1x9gknd 10450 48 as as IN cord-010119-t1x9gknd 10450 49 STAT stat NN cord-010119-t1x9gknd 10450 50 , , , cord-010119-t1x9gknd 10450 51 and and CC cord-010119-t1x9gknd 10450 52 ( ( -LRB- cord-010119-t1x9gknd 10450 53 3 3 LS cord-010119-t1x9gknd 10450 54 ) ) -RRB- cord-010119-t1x9gknd 10450 55 the the DT cord-010119-t1x9gknd 10450 56 number number NN cord-010119-t1x9gknd 10450 57 of of IN cord-010119-t1x9gknd 10450 58 expired expire VBN cord-010119-t1x9gknd 10450 59 products product NNS cord-010119-t1x9gknd 10450 60 . . . cord-010119-t1x9gknd 10451 1 We -PRON- PRP cord-010119-t1x9gknd 10451 2 created create VBD cord-010119-t1x9gknd 10451 3 in in IN cord-010119-t1x9gknd 10451 4 - - HYPH cord-010119-t1x9gknd 10451 5 house house NN cord-010119-t1x9gknd 10451 6 programs program NNS cord-010119-t1x9gknd 10451 7 on on IN cord-010119-t1x9gknd 10451 8 Visual Visual NNP cord-010119-t1x9gknd 10451 9 Basic Basic NNP cord-010119-t1x9gknd 10451 10 for for IN cord-010119-t1x9gknd 10451 11 Applications Applications NNPS cord-010119-t1x9gknd 10451 12 ( ( -LRB- cord-010119-t1x9gknd 10451 13 Microsoft Microsoft NNP cord-010119-t1x9gknd 10451 14 , , , cord-010119-t1x9gknd 10451 15 Redmond Redmond NNP cord-010119-t1x9gknd 10451 16 , , , cord-010119-t1x9gknd 10451 17 WA WA NNP cord-010119-t1x9gknd 10451 18 ) ) -RRB- cord-010119-t1x9gknd 10451 19 for for IN cord-010119-t1x9gknd 10451 20 both both CC cord-010119-t1x9gknd 10451 21 the the DT cord-010119-t1x9gknd 10451 22 calibration calibration NN cord-010119-t1x9gknd 10451 23 and and CC cord-010119-t1x9gknd 10451 24 pilot pilot NN cord-010119-t1x9gknd 10451 25 periods period NNS cord-010119-t1x9gknd 10451 26 . . . cord-010119-t1x9gknd 10452 1 2486 2486 CD cord-010119-t1x9gknd 10452 2 lines line NNS cord-010119-t1x9gknd 10452 3 of of IN cord-010119-t1x9gknd 10452 4 code code NN cord-010119-t1x9gknd 10452 5 were be VBD cord-010119-t1x9gknd 10452 6 written write VBN cord-010119-t1x9gknd 10452 7 for for IN cord-010119-t1x9gknd 10452 8 both both DT cord-010119-t1x9gknd 10452 9 programs program NNS cord-010119-t1x9gknd 10452 10 , , , cord-010119-t1x9gknd 10452 11 including include VBG cord-010119-t1x9gknd 10452 12 2 2 CD cord-010119-t1x9gknd 10452 13 class class NN cord-010119-t1x9gknd 10452 14 modules module NNS cord-010119-t1x9gknd 10452 15 and and CC cord-010119-t1x9gknd 10452 16 34 34 CD cord-010119-t1x9gknd 10452 17 distinct distinct JJ cord-010119-t1x9gknd 10452 18 subroutines subroutine NNS cord-010119-t1x9gknd 10452 19 . . . cord-010119-t1x9gknd 10453 1 Results result NNS cord-010119-t1x9gknd 10453 2 / / SYM cord-010119-t1x9gknd 10453 3 Finding finding NN cord-010119-t1x9gknd 10453 4 : : : cord-010119-t1x9gknd 10454 1 During during IN cord-010119-t1x9gknd 10454 2 the the DT cord-010119-t1x9gknd 10454 3 pilot pilot NN cord-010119-t1x9gknd 10454 4 period period NN cord-010119-t1x9gknd 10454 5 , , , cord-010119-t1x9gknd 10454 6 we -PRON- PRP cord-010119-t1x9gknd 10454 7 investigated investigate VBD cord-010119-t1x9gknd 10454 8 our -PRON- PRP$ cord-010119-t1x9gknd 10454 9 system system NN cord-010119-t1x9gknd 10454 10 's 's POS cord-010119-t1x9gknd 10454 11 noninferiority noninferiority NN cord-010119-t1x9gknd 10454 12 . . . cord-010119-t1x9gknd 10455 1 The the DT cord-010119-t1x9gknd 10455 2 average average JJ cord-010119-t1x9gknd 10455 3 weekly weekly JJ cord-010119-t1x9gknd 10455 4 T t NN cord-010119-t1x9gknd 10455 5 : : : cord-010119-t1x9gknd 10455 6 S s NN cord-010119-t1x9gknd 10455 7 ratio ratio NN cord-010119-t1x9gknd 10455 8 for for IN cord-010119-t1x9gknd 10455 9 cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 10455 10 , , , cord-010119-t1x9gknd 10455 11 plasma plasma NN cord-010119-t1x9gknd 10455 12 , , , cord-010119-t1x9gknd 10455 13 and and CC cord-010119-t1x9gknd 10455 14 RBC RBC NNP cord-010119-t1x9gknd 10455 15 , , , cord-010119-t1x9gknd 10455 16 respectively respectively RB cord-010119-t1x9gknd 10455 17 , , , cord-010119-t1x9gknd 10455 18 were be VBD cord-010119-t1x9gknd 10455 19 1.03 1.03 CD cord-010119-t1x9gknd 10455 20 , , , cord-010119-t1x9gknd 10455 21 1.21 1.21 CD cord-010119-t1x9gknd 10455 22 , , , cord-010119-t1x9gknd 10455 23 and and CC cord-010119-t1x9gknd 10455 24 1.48 1.48 CD cord-010119-t1x9gknd 10455 25 before before IN cord-010119-t1x9gknd 10455 26 the the DT cord-010119-t1x9gknd 10455 27 pilot pilot NN cord-010119-t1x9gknd 10455 28 period period NN cord-010119-t1x9gknd 10455 29 compared compare VBN cord-010119-t1x9gknd 10455 30 with with IN cord-010119-t1x9gknd 10455 31 0.88 0.88 CD cord-010119-t1x9gknd 10455 32 , , , cord-010119-t1x9gknd 10455 33 1.17 1.17 CD cord-010119-t1x9gknd 10455 34 , , , cord-010119-t1x9gknd 10455 35 and and CC cord-010119-t1x9gknd 10455 36 1.40 1.40 CD cord-010119-t1x9gknd 10455 37 during during IN cord-010119-t1x9gknd 10455 38 the the DT cord-010119-t1x9gknd 10455 39 pilot pilot NN cord-010119-t1x9gknd 10455 40 period period NN cord-010119-t1x9gknd 10455 41 . . . cord-010119-t1x9gknd 10456 1 These these DT cord-010119-t1x9gknd 10456 2 differences difference NNS cord-010119-t1x9gknd 10456 3 did do VBD cord-010119-t1x9gknd 10456 4 not not RB cord-010119-t1x9gknd 10456 5 reach reach VB cord-010119-t1x9gknd 10456 6 statistical statistical JJ cord-010119-t1x9gknd 10456 7 significance significance NN cord-010119-t1x9gknd 10456 8 ( ( -LRB- cord-010119-t1x9gknd 10456 9 p50.28 p50.28 NNP cord-010119-t1x9gknd 10456 10 ) ) -RRB- cord-010119-t1x9gknd 10456 11 . . . cord-010119-t1x9gknd 10457 1 We -PRON- PRP cord-010119-t1x9gknd 10457 2 also also RB cord-010119-t1x9gknd 10457 3 monitored monitor VBD cord-010119-t1x9gknd 10457 4 the the DT cord-010119-t1x9gknd 10457 5 number number NN cord-010119-t1x9gknd 10457 6 of of IN cord-010119-t1x9gknd 10457 7 stat stat NN cord-010119-t1x9gknd 10457 8 ordered order VBN cord-010119-t1x9gknd 10457 9 products product NNS cord-010119-t1x9gknd 10457 10 before before IN cord-010119-t1x9gknd 10457 11 and and CC cord-010119-t1x9gknd 10457 12 during during IN cord-010119-t1x9gknd 10457 13 the the DT cord-010119-t1x9gknd 10457 14 pilot pilot NN cord-010119-t1x9gknd 10457 15 period period NN cord-010119-t1x9gknd 10457 16 , , , cord-010119-t1x9gknd 10457 17 which which WDT cord-010119-t1x9gknd 10457 18 were be VBD cord-010119-t1x9gknd 10457 19 27 27 CD cord-010119-t1x9gknd 10457 20 and and CC cord-010119-t1x9gknd 10457 21 31 31 CD cord-010119-t1x9gknd 10457 22 stat stat NN cord-010119-t1x9gknd 10457 23 units unit NNS cord-010119-t1x9gknd 10457 24 per per IN cord-010119-t1x9gknd 10457 25 week week NN cord-010119-t1x9gknd 10457 26 , , , cord-010119-t1x9gknd 10457 27 respectively respectively RB cord-010119-t1x9gknd 10457 28 ( ( -LRB- cord-010119-t1x9gknd 10457 29 p50.86 p50.86 NNP cord-010119-t1x9gknd 10457 30 ) ) -RRB- cord-010119-t1x9gknd 10457 31 . . . cord-010119-t1x9gknd 10458 1 Lastly lastly RB cord-010119-t1x9gknd 10458 2 , , , cord-010119-t1x9gknd 10458 3 we -PRON- PRP cord-010119-t1x9gknd 10458 4 also also RB cord-010119-t1x9gknd 10458 5 monitored monitor VBD cord-010119-t1x9gknd 10458 6 the the DT cord-010119-t1x9gknd 10458 7 number number NN cord-010119-t1x9gknd 10458 8 of of IN cord-010119-t1x9gknd 10458 9 monthly monthly JJ cord-010119-t1x9gknd 10458 10 wasted waste VBN cord-010119-t1x9gknd 10458 11 products product NNS cord-010119-t1x9gknd 10458 12 due due JJ cord-010119-t1x9gknd 10458 13 to to IN cord-010119-t1x9gknd 10458 14 expiration expiration NN cord-010119-t1x9gknd 10458 15 as as IN cord-010119-t1x9gknd 10458 16 an an DT cord-010119-t1x9gknd 10458 17 indicator indicator NN cord-010119-t1x9gknd 10458 18 of of IN cord-010119-t1x9gknd 10458 19 inventory inventory NN cord-010119-t1x9gknd 10458 20 mismanagement mismanagement NN cord-010119-t1x9gknd 10458 21 before before RB cord-010119-t1x9gknd 10458 22 and and CC cord-010119-t1x9gknd 10458 23 during during IN cord-010119-t1x9gknd 10458 24 the the DT cord-010119-t1x9gknd 10458 25 pilot pilot NN cord-010119-t1x9gknd 10458 26 period period NN cord-010119-t1x9gknd 10458 27 , , , cord-010119-t1x9gknd 10458 28 which which WDT cord-010119-t1x9gknd 10458 29 were be VBD cord-010119-t1x9gknd 10458 30 226 226 CD cord-010119-t1x9gknd 10458 31 and and CC cord-010119-t1x9gknd 10458 32 196 196 CD cord-010119-t1x9gknd 10458 33 units unit NNS cord-010119-t1x9gknd 10458 34 , , , cord-010119-t1x9gknd 10458 35 respectively respectively RB cord-010119-t1x9gknd 10458 36 ( ( -LRB- cord-010119-t1x9gknd 10458 37 p p NN cord-010119-t1x9gknd 10458 38 5 5 CD cord-010119-t1x9gknd 10458 39 0.28 0.28 CD cord-010119-t1x9gknd 10458 40 ) ) -RRB- cord-010119-t1x9gknd 10458 41 . . . cord-010119-t1x9gknd 10459 1 An an DT cord-010119-t1x9gknd 10459 2 estimated estimate VBN cord-010119-t1x9gknd 10459 3 7 7 CD cord-010119-t1x9gknd 10459 4 hours hour NNS cord-010119-t1x9gknd 10459 5 per per IN cord-010119-t1x9gknd 10459 6 week week NN cord-010119-t1x9gknd 10459 7 of of IN cord-010119-t1x9gknd 10459 8 technologist technologist NN cord-010119-t1x9gknd 10459 9 time time NN cord-010119-t1x9gknd 10459 10 was be VBD cord-010119-t1x9gknd 10459 11 reallocated reallocate VBN cord-010119-t1x9gknd 10459 12 to to IN cord-010119-t1x9gknd 10459 13 other other JJ cord-010119-t1x9gknd 10459 14 tasks task NNS cord-010119-t1x9gknd 10459 15 once once IN cord-010119-t1x9gknd 10459 16 the the DT cord-010119-t1x9gknd 10459 17 electronic electronic JJ cord-010119-t1x9gknd 10459 18 census census NN cord-010119-t1x9gknd 10459 19 was be VBD cord-010119-t1x9gknd 10459 20 adopted adopt VBN cord-010119-t1x9gknd 10459 21 . . . cord-010119-t1x9gknd 10460 1 This this DT cord-010119-t1x9gknd 10460 2 translates translate VBZ cord-010119-t1x9gknd 10460 3 to to IN cord-010119-t1x9gknd 10460 4 0.175 0.175 CD cord-010119-t1x9gknd 10460 5 FTE fte NN cord-010119-t1x9gknd 10460 6 and and CC cord-010119-t1x9gknd 10460 7 $ $ $ cord-010119-t1x9gknd 10460 8 18,200 18,200 CD cord-010119-t1x9gknd 10460 9 per per IN cord-010119-t1x9gknd 10460 10 year year NN cord-010119-t1x9gknd 10460 11 saved save VBN cord-010119-t1x9gknd 10460 12 from from IN cord-010119-t1x9gknd 10460 13 labor labor NN cord-010119-t1x9gknd 10460 14 costs cost NNS cord-010119-t1x9gknd 10460 15 per per IN cord-010119-t1x9gknd 10460 16 year year NN cord-010119-t1x9gknd 10460 17 if if IN cord-010119-t1x9gknd 10460 18 permanently permanently RB cord-010119-t1x9gknd 10460 19 adopted adopt VBN cord-010119-t1x9gknd 10460 20 . . . cord-010119-t1x9gknd 10461 1 Conclusion conclusion NN cord-010119-t1x9gknd 10461 2 : : : cord-010119-t1x9gknd 10461 3 We -PRON- PRP cord-010119-t1x9gknd 10461 4 created create VBD cord-010119-t1x9gknd 10461 5 an an DT cord-010119-t1x9gknd 10461 6 in in IN cord-010119-t1x9gknd 10461 7 - - HYPH cord-010119-t1x9gknd 10461 8 house house NN cord-010119-t1x9gknd 10461 9 electronic electronic JJ cord-010119-t1x9gknd 10461 10 ordering order VBG cord-010119-t1x9gknd 10461 11 system system NN cord-010119-t1x9gknd 10461 12 to to TO cord-010119-t1x9gknd 10461 13 enhance enhance VB cord-010119-t1x9gknd 10461 14 information information NN cord-010119-t1x9gknd 10461 15 fidelity fidelity NN cord-010119-t1x9gknd 10461 16 , , , cord-010119-t1x9gknd 10461 17 re re NNS cord-010119-t1x9gknd 10461 18 - - VB cord-010119-t1x9gknd 10461 19 allocate allocate VB cord-010119-t1x9gknd 10461 20 technologist technologist NN cord-010119-t1x9gknd 10461 21 time time NN cord-010119-t1x9gknd 10461 22 , , , cord-010119-t1x9gknd 10461 23 and and CC cord-010119-t1x9gknd 10461 24 further further RB cord-010119-t1x9gknd 10461 25 standardize standardize VB cord-010119-t1x9gknd 10461 26 ordering ordering NN cord-010119-t1x9gknd 10461 27 . . . cord-010119-t1x9gknd 10462 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10462 2 system system NN cord-010119-t1x9gknd 10462 3 showed show VBD cord-010119-t1x9gknd 10462 4 non non JJ cord-010119-t1x9gknd 10462 5 - - JJ cord-010119-t1x9gknd 10462 6 inferiority inferiority NN cord-010119-t1x9gknd 10462 7 to to IN cord-010119-t1x9gknd 10462 8 the the DT cord-010119-t1x9gknd 10462 9 labor labor NN cord-010119-t1x9gknd 10462 10 - - HYPH cord-010119-t1x9gknd 10462 11 intensive intensive JJ cord-010119-t1x9gknd 10462 12 manual manual JJ cord-010119-t1x9gknd 10462 13 system system NN cord-010119-t1x9gknd 10462 14 , , , cord-010119-t1x9gknd 10462 15 by by IN cord-010119-t1x9gknd 10462 16 not not RB cord-010119-t1x9gknd 10462 17 changing change VBG cord-010119-t1x9gknd 10462 18 the the DT cord-010119-t1x9gknd 10462 19 number number NN cord-010119-t1x9gknd 10462 20 of of IN cord-010119-t1x9gknd 10462 21 stat stat NN cord-010119-t1x9gknd 10462 22 orders order NNS cord-010119-t1x9gknd 10462 23 , , , cord-010119-t1x9gknd 10462 24 having have VBG cord-010119-t1x9gknd 10462 25 the the DT cord-010119-t1x9gknd 10462 26 same same JJ cord-010119-t1x9gknd 10462 27 T t NN cord-010119-t1x9gknd 10462 28 : : : cord-010119-t1x9gknd 10462 29 S s NN cord-010119-t1x9gknd 10462 30 ratio ratio NN cord-010119-t1x9gknd 10462 31 , , , cord-010119-t1x9gknd 10462 32 and and CC cord-010119-t1x9gknd 10462 33 not not RB cord-010119-t1x9gknd 10462 34 increasing increase VBG cord-010119-t1x9gknd 10462 35 the the DT cord-010119-t1x9gknd 10462 36 number number NN cord-010119-t1x9gknd 10462 37 of of IN cord-010119-t1x9gknd 10462 38 expired expire VBN cord-010119-t1x9gknd 10462 39 products product NNS cord-010119-t1x9gknd 10462 40 . . . cord-010119-t1x9gknd 10463 1 This this DT cord-010119-t1x9gknd 10463 2 is be VBZ cord-010119-t1x9gknd 10463 3 achieved achieve VBN cord-010119-t1x9gknd 10463 4 while while IN cord-010119-t1x9gknd 10463 5 freeing free VBG cord-010119-t1x9gknd 10463 6 up up RP cord-010119-t1x9gknd 10463 7 over over IN cord-010119-t1x9gknd 10463 8 360 360 CD cord-010119-t1x9gknd 10463 9 hours hour NNS cord-010119-t1x9gknd 10463 10 of of IN cord-010119-t1x9gknd 10463 11 staff staff NN cord-010119-t1x9gknd 10463 12 time time NN cord-010119-t1x9gknd 10463 13 per per IN cord-010119-t1x9gknd 10463 14 year year NN cord-010119-t1x9gknd 10463 15 . . . cord-010119-t1x9gknd 10464 1 Future future JJ cord-010119-t1x9gknd 10464 2 directions direction NNS cord-010119-t1x9gknd 10464 3 include include VBP cord-010119-t1x9gknd 10464 4 full full JJ cord-010119-t1x9gknd 10464 5 automation automation NN cord-010119-t1x9gknd 10464 6 with with IN cord-010119-t1x9gknd 10464 7 involvement involvement NN cord-010119-t1x9gknd 10464 8 from from IN cord-010119-t1x9gknd 10464 9 HTS HTS NNP cord-010119-t1x9gknd 10464 10 informatics informatics NNP cord-010119-t1x9gknd 10464 11 department department NN cord-010119-t1x9gknd 10464 12 . . . cord-010119-t1x9gknd 10465 1 Transfusion transfusion NN cord-010119-t1x9gknd 10465 2 Practice practice NN cord-010119-t1x9gknd 10465 3 Improvement improvement NN cord-010119-t1x9gknd 10465 4 : : : cord-010119-t1x9gknd 10466 1 Gaining gain VBG cord-010119-t1x9gknd 10466 2 Traction traction NN cord-010119-t1x9gknd 10466 3 through through IN cord-010119-t1x9gknd 10466 4 the the DT cord-010119-t1x9gknd 10466 5 Use Use NNP cord-010119-t1x9gknd 10466 6 of of IN cord-010119-t1x9gknd 10466 7 a a DT cord-010119-t1x9gknd 10466 8 Provincial Provincial NNP cord-010119-t1x9gknd 10466 9 Transfusion Transfusion NNP cord-010119-t1x9gknd 10466 10 Quality Quality NNP cord-010119-t1x9gknd 10466 11 Improvement improvement NN cord-010119-t1x9gknd 10466 12 Plan Plan NNP cord-010119-t1x9gknd 10466 13 Denise Denise NNP cord-010119-t1x9gknd 10466 14 Evanovitch Evanovitch NNP cord-010119-t1x9gknd 10466 15 * * NFP cord-010119-t1x9gknd 10466 16 1 1 CD cord-010119-t1x9gknd 10466 17 , , , cord-010119-t1x9gknd 10466 18 Yulia Yulia NNP cord-010119-t1x9gknd 10466 19 Lin Lin NNP cord-010119-t1x9gknd 10466 20 2 2 CD cord-010119-t1x9gknd 10466 21 , , , cord-010119-t1x9gknd 10466 22 Troy Troy NNP cord-010119-t1x9gknd 10466 23 Thompson Thompson NNP cord-010119-t1x9gknd 10466 24 1 1 CD cord-010119-t1x9gknd 10466 25 , , , cord-010119-t1x9gknd 10466 26 Allison Allison NNP cord-010119-t1x9gknd 10466 27 Collins Collins NNP cord-010119-t1x9gknd 10466 28 1 1 CD cord-010119-t1x9gknd 10466 29 and and CC cord-010119-t1x9gknd 10466 30 Sheena Sheena NNP cord-010119-t1x9gknd 10466 31 Scheuermann Scheuermann NNP cord-010119-t1x9gknd 10466 32 1 1 CD cord-010119-t1x9gknd 10466 33 . . . cord-010119-t1x9gknd 10467 1 1 1 CD cord-010119-t1x9gknd 10467 2 Ontario Ontario NNP cord-010119-t1x9gknd 10467 3 Regional Regional NNP cord-010119-t1x9gknd 10467 4 Blood Blood NNP cord-010119-t1x9gknd 10467 5 Coordinating Coordinating NNP cord-010119-t1x9gknd 10467 6 Network Network NNP cord-010119-t1x9gknd 10467 7 , , , cord-010119-t1x9gknd 10467 8 2 2 CD cord-010119-t1x9gknd 10467 9 Sunnybrook Sunnybrook NNP cord-010119-t1x9gknd 10467 10 Health Health NNP cord-010119-t1x9gknd 10467 11 Sciences Sciences NNPS cord-010119-t1x9gknd 10467 12 Centre Centre NNP cord-010119-t1x9gknd 10467 13 Background Background NNP cord-010119-t1x9gknd 10467 14 / / SYM cord-010119-t1x9gknd 10467 15 Case Case NNP cord-010119-t1x9gknd 10467 16 Studies Studies NNPS cord-010119-t1x9gknd 10467 17 : : : cord-010119-t1x9gknd 10468 1 A a DT cord-010119-t1x9gknd 10468 2 provincial provincial JJ cord-010119-t1x9gknd 10468 3 regional regional JJ cord-010119-t1x9gknd 10468 4 blood blood NN cord-010119-t1x9gknd 10468 5 coordinating coordinating NN cord-010119-t1x9gknd 10468 6 network network NN cord-010119-t1x9gknd 10468 7 ( ( -LRB- cord-010119-t1x9gknd 10468 8 PRBCN PRBCN NNP cord-010119-t1x9gknd 10468 9 ) ) -RRB- cord-010119-t1x9gknd 10468 10 held hold VBD cord-010119-t1x9gknd 10468 11 a a DT cord-010119-t1x9gknd 10468 12 " " `` cord-010119-t1x9gknd 10468 13 Quality Quality NNP cord-010119-t1x9gknd 10468 14 Focus Focus NNP cord-010119-t1x9gknd 10468 15 Day Day NNP cord-010119-t1x9gknd 10468 16 " " '' cord-010119-t1x9gknd 10468 17 ( ( -LRB- cord-010119-t1x9gknd 10468 18 QFD QFD NNP cord-010119-t1x9gknd 10468 19 ) ) -RRB- cord-010119-t1x9gknd 10468 20 in in IN cord-010119-t1x9gknd 10468 21 2014 2014 CD cord-010119-t1x9gknd 10468 22 to to TO cord-010119-t1x9gknd 10468 23 explore explore VB cord-010119-t1x9gknd 10468 24 transfusion transfusion NN cord-010119-t1x9gknd 10468 25 quality quality NN cord-010119-t1x9gknd 10468 26 indicators indicator NNS cord-010119-t1x9gknd 10468 27 to to TO cord-010119-t1x9gknd 10468 28 be be VB cord-010119-t1x9gknd 10468 29 included include VBN cord-010119-t1x9gknd 10468 30 in in IN cord-010119-t1x9gknd 10468 31 a a DT cord-010119-t1x9gknd 10468 32 province province NN cord-010119-t1x9gknd 10468 33 wide wide JJ cord-010119-t1x9gknd 10468 34 quality quality NN cord-010119-t1x9gknd 10468 35 improvement improvement NN cord-010119-t1x9gknd 10468 36 plan plan NN cord-010119-t1x9gknd 10468 37 ( ( -LRB- cord-010119-t1x9gknd 10468 38 QIP QIP NNP cord-010119-t1x9gknd 10468 39 ) ) -RRB- cord-010119-t1x9gknd 10468 40 . . . cord-010119-t1x9gknd 10469 1 The the DT cord-010119-t1x9gknd 10469 2 plan plan NN cord-010119-t1x9gknd 10469 3 's 's POS cord-010119-t1x9gknd 10469 4 main main JJ cord-010119-t1x9gknd 10469 5 goal goal NN cord-010119-t1x9gknd 10469 6 is be VBZ cord-010119-t1x9gknd 10469 7 to to TO cord-010119-t1x9gknd 10469 8 reduce reduce VB cord-010119-t1x9gknd 10469 9 patient patient JJ cord-010119-t1x9gknd 10469 10 harm harm NN cord-010119-t1x9gknd 10469 11 by by IN cord-010119-t1x9gknd 10469 12 improving improve VBG cord-010119-t1x9gknd 10469 13 transfusion transfusion NN cord-010119-t1x9gknd 10469 14 practice practice NN cord-010119-t1x9gknd 10469 15 in in IN cord-010119-t1x9gknd 10469 16 hospitals hospital NNS cord-010119-t1x9gknd 10469 17 through through IN cord-010119-t1x9gknd 10469 18 the the DT cord-010119-t1x9gknd 10469 19 reduction reduction NN cord-010119-t1x9gknd 10469 20 of of IN cord-010119-t1x9gknd 10469 21 inappropriate inappropriate JJ cord-010119-t1x9gknd 10469 22 use use NN cord-010119-t1x9gknd 10469 23 . . . cord-010119-t1x9gknd 10470 1 The the DT cord-010119-t1x9gknd 10470 2 following following JJ cord-010119-t1x9gknd 10470 3 recommendations recommendation NNS cord-010119-t1x9gknd 10470 4 were be VBD cord-010119-t1x9gknd 10470 5 made make VBN cord-010119-t1x9gknd 10470 6 : : : cord-010119-t1x9gknd 10470 7 Select select VB cord-010119-t1x9gknd 10470 8 a a DT cord-010119-t1x9gknd 10470 9 blood blood NN cord-010119-t1x9gknd 10470 10 component component NN cord-010119-t1x9gknd 10470 11 that that WDT cord-010119-t1x9gknd 10470 12 most most JJS cord-010119-t1x9gknd 10470 13 hospitals hospital NNS cord-010119-t1x9gknd 10470 14 could could MD cord-010119-t1x9gknd 10470 15 monitor monitor VB cord-010119-t1x9gknd 10470 16 Display display NN cord-010119-t1x9gknd 10470 17 progress progress NN cord-010119-t1x9gknd 10470 18 in in IN cord-010119-t1x9gknd 10470 19 a a DT cord-010119-t1x9gknd 10470 20 public public JJ cord-010119-t1x9gknd 10470 21 forum forum NN cord-010119-t1x9gknd 10470 22 so so IN cord-010119-t1x9gknd 10470 23 that that IN cord-010119-t1x9gknd 10470 24 hospitals hospital NNS cord-010119-t1x9gknd 10470 25 could could MD cord-010119-t1x9gknd 10470 26 compare compare VB cord-010119-t1x9gknd 10470 27 themselves -PRON- PRP cord-010119-t1x9gknd 10470 28 to to IN cord-010119-t1x9gknd 10470 29 peers peer NNS cord-010119-t1x9gknd 10470 30 Strike strike VB cord-010119-t1x9gknd 10470 31 a a DT cord-010119-t1x9gknd 10470 32 province province NN cord-010119-t1x9gknd 10470 33 - - HYPH cord-010119-t1x9gknd 10470 34 wide wide JJ cord-010119-t1x9gknd 10470 35 transfusion transfusion NN cord-010119-t1x9gknd 10470 36 QIP QIP NNP cord-010119-t1x9gknd 10470 37 committee committee NN cord-010119-t1x9gknd 10470 38 to to TO cord-010119-t1x9gknd 10470 39 guide guide VB cord-010119-t1x9gknd 10470 40 the the DT cord-010119-t1x9gknd 10470 41 development development NN cord-010119-t1x9gknd 10470 42 of of IN cord-010119-t1x9gknd 10470 43 the the DT cord-010119-t1x9gknd 10470 44 plan plan NN cord-010119-t1x9gknd 10470 45 , , , cord-010119-t1x9gknd 10470 46 supporting support VBG cord-010119-t1x9gknd 10470 47 resources resource NNS cord-010119-t1x9gknd 10470 48 and and CC cord-010119-t1x9gknd 10470 49 ongoing ongoing JJ cord-010119-t1x9gknd 10470 50 improvement improvement NN cord-010119-t1x9gknd 10470 51 initiatives initiative NNS cord-010119-t1x9gknd 10471 1 Study Study NNP cord-010119-t1x9gknd 10471 2 Design Design NNP cord-010119-t1x9gknd 10471 3 / / SYM cord-010119-t1x9gknd 10471 4 Method method NN cord-010119-t1x9gknd 10471 5 : : : cord-010119-t1x9gknd 10472 1 A a DT cord-010119-t1x9gknd 10472 2 provincial provincial JJ cord-010119-t1x9gknd 10472 3 transfusion transfusion NN cord-010119-t1x9gknd 10472 4 quality quality NN cord-010119-t1x9gknd 10472 5 improvement improvement NN cord-010119-t1x9gknd 10472 6 plan plan NN cord-010119-t1x9gknd 10472 7 ( ( -LRB- cord-010119-t1x9gknd 10472 8 PTQIP PTQIP NNP cord-010119-t1x9gknd 10472 9 ) ) -RRB- cord-010119-t1x9gknd 10472 10 committee committee NN cord-010119-t1x9gknd 10472 11 was be VBD cord-010119-t1x9gknd 10472 12 formed form VBN cord-010119-t1x9gknd 10472 13 and and CC cord-010119-t1x9gknd 10472 14 included include VBD cord-010119-t1x9gknd 10472 15 broad broad JJ cord-010119-t1x9gknd 10472 16 representation representation NN cord-010119-t1x9gknd 10472 17 : : : cord-010119-t1x9gknd 10472 18 the the DT cord-010119-t1x9gknd 10472 19 provincial provincial JJ cord-010119-t1x9gknd 10472 20 patient patient JJ cord-010119-t1x9gknd 10472 21 blood blood NN cord-010119-t1x9gknd 10472 22 management management NN cord-010119-t1x9gknd 10472 23 coordinators coordinator NNS cord-010119-t1x9gknd 10472 24 , , , cord-010119-t1x9gknd 10472 25 physicians physician NNS cord-010119-t1x9gknd 10472 26 , , , cord-010119-t1x9gknd 10472 27 technologists technologist NNS cord-010119-t1x9gknd 10472 28 , , , cord-010119-t1x9gknd 10472 29 nurses nurse NNS cord-010119-t1x9gknd 10472 30 , , , cord-010119-t1x9gknd 10472 31 administrators administrator NNS cord-010119-t1x9gknd 10472 32 , , , cord-010119-t1x9gknd 10472 33 clinicians clinician NNS cord-010119-t1x9gknd 10472 34 , , , cord-010119-t1x9gknd 10472 35 quality quality NN cord-010119-t1x9gknd 10472 36 / / SYM cord-010119-t1x9gknd 10472 37 risk risk NN cord-010119-t1x9gknd 10472 38 managers manager NNS cord-010119-t1x9gknd 10472 39 from from IN cord-010119-t1x9gknd 10472 40 all all DT cord-010119-t1x9gknd 10472 41 regions region NNS cord-010119-t1x9gknd 10472 42 of of IN cord-010119-t1x9gknd 10472 43 the the DT cord-010119-t1x9gknd 10472 44 province province NN cord-010119-t1x9gknd 10472 45 and and CC cord-010119-t1x9gknd 10472 46 the the DT cord-010119-t1x9gknd 10472 47 provincial provincial JJ cord-010119-t1x9gknd 10472 48 blood blood NNP cord-010119-t1x9gknd 10472 49 advisory advisory NNP cord-010119-t1x9gknd 10472 50 committee committee NN cord-010119-t1x9gknd 10472 51 , , , cord-010119-t1x9gknd 10472 52 the the DT cord-010119-t1x9gknd 10472 53 blood blood NN cord-010119-t1x9gknd 10472 54 supplier supplier NN cord-010119-t1x9gknd 10472 55 and and CC cord-010119-t1x9gknd 10472 56 a a DT cord-010119-t1x9gknd 10472 57 patient patient NN cord-010119-t1x9gknd 10472 58 . . . cord-010119-t1x9gknd 10473 1 There there EX cord-010119-t1x9gknd 10473 2 was be VBD cord-010119-t1x9gknd 10473 3 further further JJ cord-010119-t1x9gknd 10473 4 collaboration collaboration NN cord-010119-t1x9gknd 10473 5 with with IN cord-010119-t1x9gknd 10473 6 other other JJ cord-010119-t1x9gknd 10473 7 organizations organization NNS cord-010119-t1x9gknd 10473 8 such such JJ cord-010119-t1x9gknd 10473 9 as as IN cord-010119-t1x9gknd 10473 10 the the DT cord-010119-t1x9gknd 10473 11 provincial provincial JJ cord-010119-t1x9gknd 10473 12 health health NN cord-010119-t1x9gknd 10473 13 quality quality NN cord-010119-t1x9gknd 10473 14 division division NN cord-010119-t1x9gknd 10473 15 , , , cord-010119-t1x9gknd 10473 16 Choosing choose VBG cord-010119-t1x9gknd 10473 17 Wisely wisely RB cord-010119-t1x9gknd 10473 18 After after IN cord-010119-t1x9gknd 10473 19 the the DT cord-010119-t1x9gknd 10473 20 launch launch NN cord-010119-t1x9gknd 10473 21 , , , cord-010119-t1x9gknd 10473 22 an an DT cord-010119-t1x9gknd 10473 23 informal informal JJ cord-010119-t1x9gknd 10473 24 survey survey NN cord-010119-t1x9gknd 10473 25 indicated indicate VBD cord-010119-t1x9gknd 10473 26 that that IN cord-010119-t1x9gknd 10473 27 74 74 CD cord-010119-t1x9gknd 10473 28 of of IN cord-010119-t1x9gknd 10473 29 the the DT cord-010119-t1x9gknd 10473 30 province province NN cord-010119-t1x9gknd 10473 31 's 's POS cord-010119-t1x9gknd 10473 32 158 158 CD cord-010119-t1x9gknd 10473 33 hospitals hospital NNS cord-010119-t1x9gknd 10473 34 were be VBD cord-010119-t1x9gknd 10473 35 interested interested JJ cord-010119-t1x9gknd 10473 36 or or CC cord-010119-t1x9gknd 10473 37 had have VBD cord-010119-t1x9gknd 10473 38 already already RB cord-010119-t1x9gknd 10473 39 adopted adopt VBN cord-010119-t1x9gknd 10473 40 portions portion NNS cord-010119-t1x9gknd 10473 41 of of IN cord-010119-t1x9gknd 10473 42 the the DT cord-010119-t1x9gknd 10473 43 PTQIP PTQIP NNP cord-010119-t1x9gknd 10473 44 . . . cord-010119-t1x9gknd 10474 1 To to TO cord-010119-t1x9gknd 10474 2 further further RB cord-010119-t1x9gknd 10474 3 assist assist VB cord-010119-t1x9gknd 10474 4 hospitals hospital NNS cord-010119-t1x9gknd 10474 5 in in IN cord-010119-t1x9gknd 10474 6 advancing advance VBG cord-010119-t1x9gknd 10474 7 their -PRON- PRP$ cord-010119-t1x9gknd 10474 8 QIPs qip NNS cord-010119-t1x9gknd 10474 9 , , , cord-010119-t1x9gknd 10474 10 a a DT cord-010119-t1x9gknd 10474 11 technologist technologist NN cord-010119-t1x9gknd 10474 12 prospective prospective JJ cord-010119-t1x9gknd 10474 13 screening screen VBG cord-010119-t1x9gknd 10474 14 educational educational JJ cord-010119-t1x9gknd 10474 15 module module NN cord-010119-t1x9gknd 10474 16 was be VBD cord-010119-t1x9gknd 10474 17 developed develop VBN cord-010119-t1x9gknd 10474 18 in in IN cord-010119-t1x9gknd 10474 19 addition addition NN cord-010119-t1x9gknd 10474 20 to to IN cord-010119-t1x9gknd 10474 21 an an DT cord-010119-t1x9gknd 10474 22 electronic electronic JJ cord-010119-t1x9gknd 10474 23 tracking tracking NN cord-010119-t1x9gknd 10474 24 tool tool NN cord-010119-t1x9gknd 10474 25 with with IN cord-010119-t1x9gknd 10474 26 which which WDT cord-010119-t1x9gknd 10474 27 hospitals hospital NNS cord-010119-t1x9gknd 10474 28 can can MD cord-010119-t1x9gknd 10474 29 enter enter VB cord-010119-t1x9gknd 10474 30 their -PRON- PRP$ cord-010119-t1x9gknd 10474 31 baseline baseline JJ cord-010119-t1x9gknd 10474 32 data datum NNS cord-010119-t1x9gknd 10474 33 and and CC cord-010119-t1x9gknd 10474 34 subsequent subsequent JJ cord-010119-t1x9gknd 10474 35 audit audit NN cord-010119-t1x9gknd 10474 36 data datum NNS cord-010119-t1x9gknd 10474 37 and and CC cord-010119-t1x9gknd 10474 38 track track VB cord-010119-t1x9gknd 10474 39 their -PRON- PRP$ cord-010119-t1x9gknd 10474 40 success success NN cord-010119-t1x9gknd 10474 41 . . . cord-010119-t1x9gknd 10475 1 Both both DT cord-010119-t1x9gknd 10475 2 hospital hospital NN cord-010119-t1x9gknd 10475 3 and and CC cord-010119-t1x9gknd 10475 4 provincial provincial JJ cord-010119-t1x9gknd 10475 5 reports report NNS cord-010119-t1x9gknd 10475 6 can can MD cord-010119-t1x9gknd 10475 7 be be VB cord-010119-t1x9gknd 10475 8 generated generate VBN cord-010119-t1x9gknd 10475 9 from from IN cord-010119-t1x9gknd 10475 10 the the DT cord-010119-t1x9gknd 10475 11 tracking tracking NN cord-010119-t1x9gknd 10475 12 tool tool NN cord-010119-t1x9gknd 10475 13 . . . cord-010119-t1x9gknd 10476 1 A a DT cord-010119-t1x9gknd 10476 2 more more RBR cord-010119-t1x9gknd 10476 3 formal formal JJ cord-010119-t1x9gknd 10476 4 survey survey NN cord-010119-t1x9gknd 10476 5 conducted conduct VBN cord-010119-t1x9gknd 10476 6 in in IN cord-010119-t1x9gknd 10476 7 2017 2017 CD cord-010119-t1x9gknd 10476 8 indicated indicate VBD cord-010119-t1x9gknd 10476 9 that that IN cord-010119-t1x9gknd 10476 10 93 93 CD cord-010119-t1x9gknd 10476 11 % % NN cord-010119-t1x9gknd 10476 12 plan plan NN cord-010119-t1x9gknd 10476 13 to to TO cord-010119-t1x9gknd 10476 14 implement implement VB cord-010119-t1x9gknd 10476 15 or or CC cord-010119-t1x9gknd 10476 16 already already RB cord-010119-t1x9gknd 10476 17 have have VB cord-010119-t1x9gknd 10476 18 implemented implement VBN cord-010119-t1x9gknd 10476 19 the the DT cord-010119-t1x9gknd 10476 20 PTQIP PTQIP NNP cord-010119-t1x9gknd 10476 21 and and CC cord-010119-t1x9gknd 10476 22 43 43 CD cord-010119-t1x9gknd 10476 23 % % NN cord-010119-t1x9gknd 10476 24 of of IN cord-010119-t1x9gknd 10476 25 the the DT cord-010119-t1x9gknd 10476 26 respondents respondent NNS cord-010119-t1x9gknd 10476 27 already already RB cord-010119-t1x9gknd 10476 28 have have VBP cord-010119-t1x9gknd 10476 29 put put VBN cord-010119-t1x9gknd 10476 30 prospective prospective JJ cord-010119-t1x9gknd 10476 31 order order NN cord-010119-t1x9gknd 10476 32 screening screening NN cord-010119-t1x9gknd 10476 33 by by IN cord-010119-t1x9gknd 10476 34 technologists technologist NNS cord-010119-t1x9gknd 10476 35 in in IN cord-010119-t1x9gknd 10476 36 place place NN cord-010119-t1x9gknd 10476 37 . . . cord-010119-t1x9gknd 10477 1 Conclusion conclusion NN cord-010119-t1x9gknd 10477 2 : : : cord-010119-t1x9gknd 10477 3 Helping help VBG cord-010119-t1x9gknd 10477 4 hospitals hospital NNS cord-010119-t1x9gknd 10477 5 through through IN cord-010119-t1x9gknd 10477 6 the the DT cord-010119-t1x9gknd 10477 7 development development NN cord-010119-t1x9gknd 10477 8 of of IN cord-010119-t1x9gknd 10477 9 standardized standardized JJ cord-010119-t1x9gknd 10477 10 templates template NNS cord-010119-t1x9gknd 10477 11 , , , cord-010119-t1x9gknd 10477 12 instructions instruction NNS cord-010119-t1x9gknd 10477 13 , , , cord-010119-t1x9gknd 10477 14 education education NN cord-010119-t1x9gknd 10477 15 and and CC cord-010119-t1x9gknd 10477 16 other other JJ cord-010119-t1x9gknd 10477 17 tools tool NNS cord-010119-t1x9gknd 10477 18 for for IN cord-010119-t1x9gknd 10477 19 transfusion transfusion NN cord-010119-t1x9gknd 10477 20 quality quality NN cord-010119-t1x9gknd 10477 21 improvement improvement NN cord-010119-t1x9gknd 10477 22 increases increase VBZ cord-010119-t1x9gknd 10477 23 the the DT cord-010119-t1x9gknd 10477 24 ability ability NN cord-010119-t1x9gknd 10477 25 of of IN cord-010119-t1x9gknd 10477 26 hospitals hospital NNS cord-010119-t1x9gknd 10477 27 to to IN cord-010119-t1x9gknd 10477 28 uptake uptake NN cord-010119-t1x9gknd 10477 29 quality quality NN cord-010119-t1x9gknd 10477 30 improvement improvement NN cord-010119-t1x9gknd 10477 31 initiatives initiative NNS cord-010119-t1x9gknd 10477 32 . . . cord-010119-t1x9gknd 10478 1 Taking take VBG cord-010119-t1x9gknd 10478 2 a a DT cord-010119-t1x9gknd 10478 3 standardized standardized JJ cord-010119-t1x9gknd 10478 4 approach approach NN cord-010119-t1x9gknd 10478 5 across across IN cord-010119-t1x9gknd 10478 6 the the DT cord-010119-t1x9gknd 10478 7 province province NN cord-010119-t1x9gknd 10478 8 allows allow VBZ cord-010119-t1x9gknd 10478 9 for for IN cord-010119-t1x9gknd 10478 10 both both DT cord-010119-t1x9gknd 10478 11 aggregate aggregate NN cord-010119-t1x9gknd 10478 12 and and CC cord-010119-t1x9gknd 10478 13 hospital hospital NN cord-010119-t1x9gknd 10478 14 data data NN cord-010119-t1x9gknd 10478 15 comparison comparison NN cord-010119-t1x9gknd 10478 16 analyses analysis NNS cord-010119-t1x9gknd 10478 17 . . . cord-010119-t1x9gknd 10479 1 Background Background NNP cord-010119-t1x9gknd 10479 2 / / SYM cord-010119-t1x9gknd 10479 3 Case Case NNP cord-010119-t1x9gknd 10479 4 Studies Studies NNPS cord-010119-t1x9gknd 10479 5 : : : cord-010119-t1x9gknd 10480 1 Military military JJ cord-010119-t1x9gknd 10480 2 and and CC cord-010119-t1x9gknd 10480 3 civilian civilian JJ cord-010119-t1x9gknd 10480 4 trauma trauma NN cord-010119-t1x9gknd 10480 5 - - HYPH cord-010119-t1x9gknd 10480 6 based base VBN cord-010119-t1x9gknd 10480 7 studies study NNS cord-010119-t1x9gknd 10480 8 have have VBP cord-010119-t1x9gknd 10480 9 demonstrated demonstrate VBN cord-010119-t1x9gknd 10480 10 the the DT cord-010119-t1x9gknd 10480 11 advantages advantage NNS cord-010119-t1x9gknd 10480 12 of of IN cord-010119-t1x9gknd 10480 13 transfusing transfuse VBG cord-010119-t1x9gknd 10480 14 blood blood NN cord-010119-t1x9gknd 10480 15 products product NNS cord-010119-t1x9gknd 10480 16 prior prior RB cord-010119-t1x9gknd 10480 17 to to IN cord-010119-t1x9gknd 10480 18 a a DT cord-010119-t1x9gknd 10480 19 patient patient NN cord-010119-t1x9gknd 10480 20 's 's POS cord-010119-t1x9gknd 10480 21 hospital hospital NN cord-010119-t1x9gknd 10480 22 arrival arrival NN cord-010119-t1x9gknd 10480 23 , , , cord-010119-t1x9gknd 10480 24 a a DT cord-010119-t1x9gknd 10480 25 process process NN cord-010119-t1x9gknd 10480 26 known know VBN cord-010119-t1x9gknd 10480 27 as as IN cord-010119-t1x9gknd 10480 28 Pre Pre NNP cord-010119-t1x9gknd 10480 29 - - NNP cord-010119-t1x9gknd 10480 30 Hospital Hospital NNP cord-010119-t1x9gknd 10480 31 Transfusion Transfusion NNP cord-010119-t1x9gknd 10480 32 ( ( -LRB- cord-010119-t1x9gknd 10480 33 PHT PHT NNP cord-010119-t1x9gknd 10480 34 ) ) -RRB- cord-010119-t1x9gknd 10480 35 . . . cord-010119-t1x9gknd 10481 1 Helicopter helicopter NN cord-010119-t1x9gknd 10481 2 emergency emergency NN cord-010119-t1x9gknd 10481 3 medical medical JJ cord-010119-t1x9gknd 10481 4 services service NNS cord-010119-t1x9gknd 10481 5 ( ( -LRB- cord-010119-t1x9gknd 10481 6 HEMS HEMS NNP cord-010119-t1x9gknd 10481 7 ) ) -RRB- cord-010119-t1x9gknd 10481 8 worldwide worldwide RB cord-010119-t1x9gknd 10481 9 have have VBP cord-010119-t1x9gknd 10481 10 implemented implement VBN cord-010119-t1x9gknd 10481 11 this this DT cord-010119-t1x9gknd 10481 12 protocol protocol NN cord-010119-t1x9gknd 10481 13 with with IN cord-010119-t1x9gknd 10481 14 great great JJ cord-010119-t1x9gknd 10481 15 success success NN cord-010119-t1x9gknd 10481 16 , , , cord-010119-t1x9gknd 10481 17 despite despite IN cord-010119-t1x9gknd 10481 18 a a DT cord-010119-t1x9gknd 10481 19 current current JJ cord-010119-t1x9gknd 10481 20 lack lack NN cord-010119-t1x9gknd 10481 21 of of IN cord-010119-t1x9gknd 10481 22 guidance guidance NN cord-010119-t1x9gknd 10481 23 or or CC cord-010119-t1x9gknd 10481 24 advisory advisory JJ cord-010119-t1x9gknd 10481 25 publications publication NNS cord-010119-t1x9gknd 10481 26 . . . cord-010119-t1x9gknd 10482 1 There there EX cord-010119-t1x9gknd 10482 2 is be VBZ cord-010119-t1x9gknd 10482 3 a a DT cord-010119-t1x9gknd 10482 4 need need NN cord-010119-t1x9gknd 10482 5 for for IN cord-010119-t1x9gknd 10482 6 literature literature NN cord-010119-t1x9gknd 10482 7 that that WDT cord-010119-t1x9gknd 10482 8 addresses address VBZ cord-010119-t1x9gknd 10482 9 the the DT cord-010119-t1x9gknd 10482 10 regulatory regulatory JJ cord-010119-t1x9gknd 10482 11 requirements requirement NNS cord-010119-t1x9gknd 10482 12 and and CC cord-010119-t1x9gknd 10482 13 logistical logistical JJ cord-010119-t1x9gknd 10482 14 challenges challenge NNS cord-010119-t1x9gknd 10482 15 associated associate VBN cord-010119-t1x9gknd 10482 16 with with IN cord-010119-t1x9gknd 10482 17 developing develop VBG cord-010119-t1x9gknd 10482 18 a a DT cord-010119-t1x9gknd 10482 19 PHT PHT NNP cord-010119-t1x9gknd 10482 20 program program NN cord-010119-t1x9gknd 10482 21 . . . cord-010119-t1x9gknd 10483 1 Herein herein RB cord-010119-t1x9gknd 10483 2 , , , cord-010119-t1x9gknd 10483 3 we -PRON- PRP cord-010119-t1x9gknd 10483 4 report report VBP cord-010119-t1x9gknd 10483 5 our -PRON- PRP$ cord-010119-t1x9gknd 10483 6 experience experience NN cord-010119-t1x9gknd 10483 7 as as IN cord-010119-t1x9gknd 10483 8 a a DT cord-010119-t1x9gknd 10483 9 large large JJ cord-010119-t1x9gknd 10483 10 hospital hospital NN cord-010119-t1x9gknd 10483 11 system system NN cord-010119-t1x9gknd 10483 12 embarking embark VBG cord-010119-t1x9gknd 10483 13 on on IN cord-010119-t1x9gknd 10483 14 the the DT cord-010119-t1x9gknd 10483 15 development development NN cord-010119-t1x9gknd 10483 16 of of IN cord-010119-t1x9gknd 10483 17 a a DT cord-010119-t1x9gknd 10483 18 multi multi JJ cord-010119-t1x9gknd 10483 19 - - JJ cord-010119-t1x9gknd 10483 20 state state JJ cord-010119-t1x9gknd 10483 21 PHT PHT NNP cord-010119-t1x9gknd 10483 22 service service NN cord-010119-t1x9gknd 10483 23 . . . cord-010119-t1x9gknd 10484 1 Study Study NNP cord-010119-t1x9gknd 10484 2 Design Design NNP cord-010119-t1x9gknd 10484 3 / / SYM cord-010119-t1x9gknd 10484 4 Method method NN cord-010119-t1x9gknd 10484 5 : : : cord-010119-t1x9gknd 10484 6 In in IN cord-010119-t1x9gknd 10484 7 October October NNP cord-010119-t1x9gknd 10484 8 2016 2016 CD cord-010119-t1x9gknd 10484 9 a a DT cord-010119-t1x9gknd 10484 10 work work NN cord-010119-t1x9gknd 10484 11 group group NN cord-010119-t1x9gknd 10484 12 was be VBD cord-010119-t1x9gknd 10484 13 formed form VBN cord-010119-t1x9gknd 10484 14 to to TO cord-010119-t1x9gknd 10484 15 establish establish VB cord-010119-t1x9gknd 10484 16 PHT PHT NNP cord-010119-t1x9gknd 10484 17 services service NNS cord-010119-t1x9gknd 10484 18 for for IN cord-010119-t1x9gknd 10484 19 the the DT cord-010119-t1x9gknd 10484 20 HEMS HEMS NNPS cord-010119-t1x9gknd 10484 21 providing provide VBG cord-010119-t1x9gknd 10484 22 care care NN cord-010119-t1x9gknd 10484 23 to to IN cord-010119-t1x9gknd 10484 24 over over IN cord-010119-t1x9gknd 10484 25 thirty thirty CD cord-010119-t1x9gknd 10484 26 regional regional JJ cord-010119-t1x9gknd 10484 27 hospitals hospital NNS cord-010119-t1x9gknd 10484 28 . . . cord-010119-t1x9gknd 10485 1 Composed compose VBN cord-010119-t1x9gknd 10485 2 of of IN cord-010119-t1x9gknd 10485 3 flight flight NN cord-010119-t1x9gknd 10485 4 care care NN cord-010119-t1x9gknd 10485 5 staff staff NN cord-010119-t1x9gknd 10485 6 , , , cord-010119-t1x9gknd 10485 7 emergency emergency NN cord-010119-t1x9gknd 10485 8 physicians physician NNS cord-010119-t1x9gknd 10485 9 and and CC cord-010119-t1x9gknd 10485 10 transfusion transfusion NN cord-010119-t1x9gknd 10485 11 medicine medicine NN cord-010119-t1x9gknd 10485 12 specialists specialist NNS cord-010119-t1x9gknd 10485 13 , , , cord-010119-t1x9gknd 10485 14 the the DT cord-010119-t1x9gknd 10485 15 group group NN cord-010119-t1x9gknd 10485 16 identified identify VBD cord-010119-t1x9gknd 10485 17 the the DT cord-010119-t1x9gknd 10485 18 major major JJ cord-010119-t1x9gknd 10485 19 tasks task NNS cord-010119-t1x9gknd 10485 20 to to TO cord-010119-t1x9gknd 10485 21 be be VB cord-010119-t1x9gknd 10485 22 addressed address VBN cord-010119-t1x9gknd 10485 23 : : : cord-010119-t1x9gknd 10485 24 Federal Federal NNP cord-010119-t1x9gknd 10485 25 / / SYM cord-010119-t1x9gknd 10485 26 State State NNP cord-010119-t1x9gknd 10485 27 Regulations Regulations NNPS cord-010119-t1x9gknd 10485 28 ; ; : cord-010119-t1x9gknd 10485 29 Inventory Inventory NNP cord-010119-t1x9gknd 10485 30 Structure Structure NNP cord-010119-t1x9gknd 10485 31 / / SYM cord-010119-t1x9gknd 10485 32 Management Management NNP cord-010119-t1x9gknd 10485 33 ; ; : cord-010119-t1x9gknd 10485 34 Product Product NNP cord-010119-t1x9gknd 10485 35 Storage Storage NNP cord-010119-t1x9gknd 10485 36 / / SYM cord-010119-t1x9gknd 10485 37 Testing testing NN cord-010119-t1x9gknd 10485 38 ; ; : cord-010119-t1x9gknd 10485 39 Tracking tracking NN cord-010119-t1x9gknd 10485 40 / / SYM cord-010119-t1x9gknd 10485 41 Traceability Traceability NNP cord-010119-t1x9gknd 10485 42 ; ; : cord-010119-t1x9gknd 10485 43 Emergency Emergency NNP cord-010119-t1x9gknd 10485 44 Release Release NNP cord-010119-t1x9gknd 10485 45 Protocol Protocol NNP cord-010119-t1x9gknd 10485 46 ; ; : cord-010119-t1x9gknd 10485 47 and and CC cord-010119-t1x9gknd 10485 48 Staff Staff NNP cord-010119-t1x9gknd 10485 49 Training Training NNP cord-010119-t1x9gknd 10485 50 . . . cord-010119-t1x9gknd 10486 1 While while IN cord-010119-t1x9gknd 10486 2 there there EX cord-010119-t1x9gknd 10486 3 are be VBP cord-010119-t1x9gknd 10486 4 no no DT cord-010119-t1x9gknd 10486 5 specific specific JJ cord-010119-t1x9gknd 10486 6 regulations regulation NNS cord-010119-t1x9gknd 10486 7 governing govern VBG cord-010119-t1x9gknd 10486 8 PHT PHT NNP cord-010119-t1x9gknd 10486 9 , , , cord-010119-t1x9gknd 10486 10 the the DT cord-010119-t1x9gknd 10486 11 regulations regulation NNS cord-010119-t1x9gknd 10486 12 pertaining pertain VBG cord-010119-t1x9gknd 10486 13 to to IN cord-010119-t1x9gknd 10486 14 blood blood NN cord-010119-t1x9gknd 10486 15 product product NN cord-010119-t1x9gknd 10486 16 storage storage NN cord-010119-t1x9gknd 10486 17 , , , cord-010119-t1x9gknd 10486 18 validation validation NN cord-010119-t1x9gknd 10486 19 , , , cord-010119-t1x9gknd 10486 20 and and CC cord-010119-t1x9gknd 10486 21 monitoring monitoring NN cord-010119-t1x9gknd 10486 22 apply apply NN cord-010119-t1x9gknd 10486 23 . . . cord-010119-t1x9gknd 10487 1 The the DT cord-010119-t1x9gknd 10487 2 FDA FDA NNP cord-010119-t1x9gknd 10487 3 , , , cord-010119-t1x9gknd 10487 4 AABB AABB NNP cord-010119-t1x9gknd 10487 5 , , , cord-010119-t1x9gknd 10487 6 and and CC cord-010119-t1x9gknd 10487 7 state state NN cord-010119-t1x9gknd 10487 8 agencies agency NNS cord-010119-t1x9gknd 10487 9 were be VBD cord-010119-t1x9gknd 10487 10 each each DT cord-010119-t1x9gknd 10487 11 consulted consult VBN cord-010119-t1x9gknd 10487 12 to to TO cord-010119-t1x9gknd 10487 13 ensure ensure VB cord-010119-t1x9gknd 10487 14 compliance compliance NN cord-010119-t1x9gknd 10487 15 with with IN cord-010119-t1x9gknd 10487 16 all all DT cord-010119-t1x9gknd 10487 17 directives directive NNS cord-010119-t1x9gknd 10487 18 . . . cord-010119-t1x9gknd 10488 1 Results result NNS cord-010119-t1x9gknd 10488 2 / / SYM cord-010119-t1x9gknd 10488 3 Finding finding NN cord-010119-t1x9gknd 10488 4 : : : cord-010119-t1x9gknd 10488 5 The the DT cord-010119-t1x9gknd 10488 6 largest large JJS cord-010119-t1x9gknd 10488 7 hospital hospital NN cord-010119-t1x9gknd 10488 8 within within IN cord-010119-t1x9gknd 10488 9 this this DT cord-010119-t1x9gknd 10488 10 system system NN cord-010119-t1x9gknd 10488 11 , , , cord-010119-t1x9gknd 10488 12 already already RB cord-010119-t1x9gknd 10488 13 acting act VBG cord-010119-t1x9gknd 10488 14 as as IN cord-010119-t1x9gknd 10488 15 a a DT cord-010119-t1x9gknd 10488 16 reference reference NN cord-010119-t1x9gknd 10488 17 site site NN cord-010119-t1x9gknd 10488 18 , , , cord-010119-t1x9gknd 10488 19 was be VBD cord-010119-t1x9gknd 10488 20 designated designate VBN cord-010119-t1x9gknd 10488 21 to to TO cord-010119-t1x9gknd 10488 22 perform perform VB cord-010119-t1x9gknd 10488 23 all all DT cord-010119-t1x9gknd 10488 24 confirmatory confirmatory JJ cord-010119-t1x9gknd 10488 25 testing testing NN cord-010119-t1x9gknd 10488 26 on on IN cord-010119-t1x9gknd 10488 27 products product NNS cord-010119-t1x9gknd 10488 28 supplied supply VBN cord-010119-t1x9gknd 10488 29 to to IN cord-010119-t1x9gknd 10488 30 the the DT cord-010119-t1x9gknd 10488 31 multi multi JJ cord-010119-t1x9gknd 10488 32 - - JJ cord-010119-t1x9gknd 10488 33 state state JJ cord-010119-t1x9gknd 10488 34 HEMS HEMS NNP cord-010119-t1x9gknd 10488 35 . . . cord-010119-t1x9gknd 10489 1 Similarly similarly RB cord-010119-t1x9gknd 10489 2 , , , cord-010119-t1x9gknd 10489 3 this this DT cord-010119-t1x9gknd 10489 4 hospital hospital NN cord-010119-t1x9gknd 10489 5 was be VBD cord-010119-t1x9gknd 10489 6 tasked task VBN cord-010119-t1x9gknd 10489 7 with with IN cord-010119-t1x9gknd 10489 8 remote remote JJ cord-010119-t1x9gknd 10489 9 monitoring monitoring NN cord-010119-t1x9gknd 10489 10 of of IN cord-010119-t1x9gknd 10489 11 all all DT cord-010119-t1x9gknd 10489 12 blood blood NN cord-010119-t1x9gknd 10489 13 refrigerators refrigerator NNS cord-010119-t1x9gknd 10489 14 at at IN cord-010119-t1x9gknd 10489 15 the the DT cord-010119-t1x9gknd 10489 16 helipad helipad NN cord-010119-t1x9gknd 10489 17 sites site NNS cord-010119-t1x9gknd 10489 18 . . . cord-010119-t1x9gknd 10490 1 The the DT cord-010119-t1x9gknd 10490 2 system system NN cord-010119-t1x9gknd 10490 3 's 's POS cord-010119-t1x9gknd 10490 4 FDA FDA NNP cord-010119-t1x9gknd 10490 5 licensed licensed JJ cord-010119-t1x9gknd 10490 6 blood blood NN cord-010119-t1x9gknd 10490 7 supplier supplier NN cord-010119-t1x9gknd 10490 8 was be VBD cord-010119-t1x9gknd 10490 9 deemed deem VBN cord-010119-t1x9gknd 10490 10 responsible responsible JJ cord-010119-t1x9gknd 10490 11 for for IN cord-010119-t1x9gknd 10490 12 product product NN cord-010119-t1x9gknd 10490 13 consignment consignment NN cord-010119-t1x9gknd 10490 14 and and CC cord-010119-t1x9gknd 10490 15 transport transport NN cord-010119-t1x9gknd 10490 16 between between IN cord-010119-t1x9gknd 10490 17 the the DT cord-010119-t1x9gknd 10490 18 four four CD cord-010119-t1x9gknd 10490 19 HEMS HEMS NNP cord-010119-t1x9gknd 10490 20 sites site NNS cord-010119-t1x9gknd 10490 21 . . . cord-010119-t1x9gknd 10491 1 The the DT cord-010119-t1x9gknd 10491 2 blood blood NN cord-010119-t1x9gknd 10491 3 inventory inventory NN cord-010119-t1x9gknd 10491 4 at at IN cord-010119-t1x9gknd 10491 5 each each DT cord-010119-t1x9gknd 10491 6 site site NN cord-010119-t1x9gknd 10491 7 was be VBD cord-010119-t1x9gknd 10491 8 designed design VBN cord-010119-t1x9gknd 10491 9 to to TO cord-010119-t1x9gknd 10491 10 contain contain VB cord-010119-t1x9gknd 10491 11 : : : cord-010119-t1x9gknd 10491 12 group group NN cord-010119-t1x9gknd 10491 13 O o NN cord-010119-t1x9gknd 10491 14 positive positive JJ cord-010119-t1x9gknd 10491 15 RBCs rbc NNS cord-010119-t1x9gknd 10491 16 , , , cord-010119-t1x9gknd 10491 17 group group NN cord-010119-t1x9gknd 10491 18 A a DT cord-010119-t1x9gknd 10491 19 low low JJ cord-010119-t1x9gknd 10491 20 anti anti AFX cord-010119-t1x9gknd 10491 21 - - JJ cord-010119-t1x9gknd 10491 22 B b JJ cord-010119-t1x9gknd 10491 23 titer titer NN cord-010119-t1x9gknd 10491 24 liquid liquid NN cord-010119-t1x9gknd 10491 25 plasma plasma NN cord-010119-t1x9gknd 10491 26 , , , cord-010119-t1x9gknd 10491 27 and and CC cord-010119-t1x9gknd 10491 28 four four CD cord-010119-t1x9gknd 10491 29 - - HYPH cord-010119-t1x9gknd 10491 30 factor factor NN cord-010119-t1x9gknd 10491 31 prothrombin prothrombin NN cord-010119-t1x9gknd 10491 32 complex complex NN cord-010119-t1x9gknd 10491 33 concentrate concentrate NN cord-010119-t1x9gknd 10491 34 . . . cord-010119-t1x9gknd 10492 1 A a DT cord-010119-t1x9gknd 10492 2 military military NN cord-010119-t1x9gknd 10492 3 - - HYPH cord-010119-t1x9gknd 10492 4 tested test VBN cord-010119-t1x9gknd 10492 5 in in IN cord-010119-t1x9gknd 10492 6 - - HYPH cord-010119-t1x9gknd 10492 7 flight flight NN cord-010119-t1x9gknd 10492 8 medical medical JJ cord-010119-t1x9gknd 10492 9 record record NN cord-010119-t1x9gknd 10492 10 system system NN cord-010119-t1x9gknd 10492 11 will will MD cord-010119-t1x9gknd 10492 12 be be VB cord-010119-t1x9gknd 10492 13 used use VBN cord-010119-t1x9gknd 10492 14 to to TO cord-010119-t1x9gknd 10492 15 transfer transfer VB cord-010119-t1x9gknd 10492 16 transfusion transfusion NN cord-010119-t1x9gknd 10492 17 information information NN cord-010119-t1x9gknd 10492 18 to to IN cord-010119-t1x9gknd 10492 19 non non JJ cord-010119-t1x9gknd 10492 20 - - JJ cord-010119-t1x9gknd 10492 21 affiliated affiliated JJ cord-010119-t1x9gknd 10492 22 hospitals hospital NNS cord-010119-t1x9gknd 10492 23 as as IN cord-010119-t1x9gknd 10492 24 needed need VBN cord-010119-t1x9gknd 10492 25 . . . cord-010119-t1x9gknd 10493 1 Validated validate VBN cord-010119-t1x9gknd 10493 2 inflight inflight NN cord-010119-t1x9gknd 10493 3 coolers cooler NNS cord-010119-t1x9gknd 10493 4 , , , cord-010119-t1x9gknd 10493 5 protocol protocol NN cord-010119-t1x9gknd 10493 6 for for IN cord-010119-t1x9gknd 10493 7 product product NN cord-010119-t1x9gknd 10493 8 emergency emergency NN cord-010119-t1x9gknd 10493 9 release release NN cord-010119-t1x9gknd 10493 10 , , , cord-010119-t1x9gknd 10493 11 inventory inventory NN cord-010119-t1x9gknd 10493 12 tracking tracking NN cord-010119-t1x9gknd 10493 13 system system NN cord-010119-t1x9gknd 10493 14 , , , cord-010119-t1x9gknd 10493 15 and and CC cord-010119-t1x9gknd 10493 16 re re JJ cord-010119-t1x9gknd 10493 17 - - JJ cord-010119-t1x9gknd 10493 18 stocking stocking JJ cord-010119-t1x9gknd 10493 19 schedule schedule NN cord-010119-t1x9gknd 10493 20 were be VBD cord-010119-t1x9gknd 10493 21 also also RB cord-010119-t1x9gknd 10493 22 requisite requisite JJ cord-010119-t1x9gknd 10493 23 to to IN cord-010119-t1x9gknd 10493 24 this this DT cord-010119-t1x9gknd 10493 25 plan plan NN cord-010119-t1x9gknd 10493 26 . . . cord-010119-t1x9gknd 10494 1 Staff staff NN cord-010119-t1x9gknd 10494 2 competencies competency NNS cord-010119-t1x9gknd 10494 3 regarding regard VBG cord-010119-t1x9gknd 10494 4 emergency emergency NN cord-010119-t1x9gknd 10494 5 release release NN cord-010119-t1x9gknd 10494 6 guidelines guideline NNS cord-010119-t1x9gknd 10494 7 , , , cord-010119-t1x9gknd 10494 8 transfusion transfusion NN cord-010119-t1x9gknd 10494 9 reactions reaction NNS cord-010119-t1x9gknd 10494 10 , , , cord-010119-t1x9gknd 10494 11 and and CC cord-010119-t1x9gknd 10494 12 the the DT cord-010119-t1x9gknd 10494 13 handling handling NN cord-010119-t1x9gknd 10494 14 / / SYM cord-010119-t1x9gknd 10494 15 storage storage NN cord-010119-t1x9gknd 10494 16 of of IN cord-010119-t1x9gknd 10494 17 products product NNS cord-010119-t1x9gknd 10494 18 are be VBP cord-010119-t1x9gknd 10494 19 maintained maintain VBN cord-010119-t1x9gknd 10494 20 by by IN cord-010119-t1x9gknd 10494 21 the the DT cord-010119-t1x9gknd 10494 22 HEMS HEMS NNP cord-010119-t1x9gknd 10494 23 medical medical JJ cord-010119-t1x9gknd 10494 24 director director NN cord-010119-t1x9gknd 10494 25 with with IN cord-010119-t1x9gknd 10494 26 additional additional JJ cord-010119-t1x9gknd 10494 27 oversight oversight NN cord-010119-t1x9gknd 10494 28 provided provide VBN cord-010119-t1x9gknd 10494 29 by by IN cord-010119-t1x9gknd 10494 30 transfusion transfusion NN cord-010119-t1x9gknd 10494 31 medicine medicine NN cord-010119-t1x9gknd 10494 32 physicians physician NNS cord-010119-t1x9gknd 10494 33 . . . cord-010119-t1x9gknd 10495 1 Conclusion conclusion NN cord-010119-t1x9gknd 10495 2 : : : cord-010119-t1x9gknd 10496 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10496 2 work work NN cord-010119-t1x9gknd 10496 3 group group NN cord-010119-t1x9gknd 10496 4 successfully successfully RB cord-010119-t1x9gknd 10496 5 identified identify VBD cord-010119-t1x9gknd 10496 6 the the DT cord-010119-t1x9gknd 10496 7 challenges challenge NNS cord-010119-t1x9gknd 10496 8 associated associate VBN cord-010119-t1x9gknd 10496 9 with with IN cord-010119-t1x9gknd 10496 10 a a DT cord-010119-t1x9gknd 10496 11 multi multi JJ cord-010119-t1x9gknd 10496 12 - - JJ cord-010119-t1x9gknd 10496 13 state state JJ cord-010119-t1x9gknd 10496 14 PHT PHT NNP cord-010119-t1x9gknd 10496 15 helicopter helicopter NN cord-010119-t1x9gknd 10496 16 based base VBN cord-010119-t1x9gknd 10496 17 service service NN cord-010119-t1x9gknd 10496 18 , , , cord-010119-t1x9gknd 10496 19 which which WDT cord-010119-t1x9gknd 10496 20 spans span VBZ cord-010119-t1x9gknd 10496 21 blood blood NN cord-010119-t1x9gknd 10496 22 product product NN cord-010119-t1x9gknd 10496 23 management management NN cord-010119-t1x9gknd 10496 24 , , , cord-010119-t1x9gknd 10496 25 adaptation adaptation NN cord-010119-t1x9gknd 10496 26 of of IN cord-010119-t1x9gknd 10496 27 existing exist VBG cord-010119-t1x9gknd 10496 28 transfusion transfusion NN cord-010119-t1x9gknd 10496 29 procedures procedure NNS cord-010119-t1x9gknd 10496 30 and and CC cord-010119-t1x9gknd 10496 31 operating operate VBG cord-010119-t1x9gknd 10496 32 policies policy NNS cord-010119-t1x9gknd 10496 33 , , , cord-010119-t1x9gknd 10496 34 licensing licensing NN cord-010119-t1x9gknd 10496 35 requirements requirement NNS cord-010119-t1x9gknd 10496 36 , , , cord-010119-t1x9gknd 10496 37 and and CC cord-010119-t1x9gknd 10496 38 personnel personnel NNS cord-010119-t1x9gknd 10496 39 training training NN cord-010119-t1x9gknd 10496 40 . . . cord-010119-t1x9gknd 10497 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10497 2 PHT PHT NNP cord-010119-t1x9gknd 10497 3 service service NN cord-010119-t1x9gknd 10497 4 will will MD cord-010119-t1x9gknd 10497 5 go go VB cord-010119-t1x9gknd 10497 6 live live VB cord-010119-t1x9gknd 10497 7 in in IN cord-010119-t1x9gknd 10497 8 2017 2017 CD cord-010119-t1x9gknd 10497 9 . . . cord-010119-t1x9gknd 10498 1 Publishing publish VBG cord-010119-t1x9gknd 10498 2 this this DT cord-010119-t1x9gknd 10498 3 experience experience NN cord-010119-t1x9gknd 10498 4 may may MD cord-010119-t1x9gknd 10498 5 benefit benefit VB cord-010119-t1x9gknd 10498 6 future future JJ cord-010119-t1x9gknd 10498 7 sites site NNS cord-010119-t1x9gknd 10498 8 as as IN cord-010119-t1x9gknd 10498 9 they -PRON- PRP cord-010119-t1x9gknd 10498 10 launch launch VBP cord-010119-t1x9gknd 10498 11 similar similar JJ cord-010119-t1x9gknd 10498 12 PHT PHT NNP cord-010119-t1x9gknd 10498 13 initiatives initiative NNS cord-010119-t1x9gknd 10498 14 . . . cord-010119-t1x9gknd 10499 1 Blood blood NN cord-010119-t1x9gknd 10499 2 Transfusion transfusion NN cord-010119-t1x9gknd 10499 3 during during IN cord-010119-t1x9gknd 10499 4 Humanitarian Humanitarian NNP cord-010119-t1x9gknd 10499 5 Emergencies emergency NNS cord-010119-t1x9gknd 10500 1 Yetmgeta Yetmgeta NNP cord-010119-t1x9gknd 10500 2 E. E. NNP cord-010119-t1x9gknd 10500 3 Abdella Abdella NNP cord-010119-t1x9gknd 10500 4 * * NFP cord-010119-t1x9gknd 10501 1 1 1 LS cord-010119-t1x9gknd 10501 2 , , , cord-010119-t1x9gknd 10501 3 Rana Rana NNP cord-010119-t1x9gknd 10501 4 Hajjeh Hajjeh NNP cord-010119-t1x9gknd 10501 5 1 1 CD cord-010119-t1x9gknd 10501 6 and and CC cord-010119-t1x9gknd 10501 7 Cees Cees NNP cord-010119-t1x9gknd 10501 8 Th Th NNP cord-010119-t1x9gknd 10501 9 . . . cord-010119-t1x9gknd 10502 1 Smit Smit NNP cord-010119-t1x9gknd 10502 2 Sibinga Sibinga NNP cord-010119-t1x9gknd 10502 3 2 2 CD cord-010119-t1x9gknd 10502 4 . . . cord-010119-t1x9gknd 10503 1 1 1 LS cord-010119-t1x9gknd 10504 1 World World NNP cord-010119-t1x9gknd 10504 2 Health Health NNP cord-010119-t1x9gknd 10504 3 Organization Organization NNP cord-010119-t1x9gknd 10504 4 Regional Regional NNP cord-010119-t1x9gknd 10504 5 Office Office NNP cord-010119-t1x9gknd 10504 6 for for IN cord-010119-t1x9gknd 10504 7 the the DT cord-010119-t1x9gknd 10504 8 Eastern Eastern NNP cord-010119-t1x9gknd 10504 9 Mediterranean Mediterranean NNP cord-010119-t1x9gknd 10504 10 , , , cord-010119-t1x9gknd 10504 11 2 2 CD cord-010119-t1x9gknd 10504 12 International International NNP cord-010119-t1x9gknd 10504 13 Quality Quality NNP cord-010119-t1x9gknd 10504 14 Management Management NNP cord-010119-t1x9gknd 10504 15 ( ( -LRB- cord-010119-t1x9gknd 10504 16 IQM IQM NNP cord-010119-t1x9gknd 10504 17 ) ) -RRB- cord-010119-t1x9gknd 10505 1 Consulting Consulting NNP cord-010119-t1x9gknd 10505 2 Background Background NNP cord-010119-t1x9gknd 10505 3 / / SYM cord-010119-t1x9gknd 10505 4 Case Case NNP cord-010119-t1x9gknd 10505 5 Studies Studies NNPS cord-010119-t1x9gknd 10505 6 : : : cord-010119-t1x9gknd 10505 7 More More JJR cord-010119-t1x9gknd 10505 8 than than IN cord-010119-t1x9gknd 10505 9 76 76 CD cord-010119-t1x9gknd 10505 10 million million CD cord-010119-t1x9gknd 10505 11 people people NNS cord-010119-t1x9gknd 10505 12 are be VBP cord-010119-t1x9gknd 10505 13 affected affect VBN cord-010119-t1x9gknd 10505 14 by by IN cord-010119-t1x9gknd 10505 15 humanitarian humanitarian JJ cord-010119-t1x9gknd 10505 16 emergencies emergency NNS cord-010119-t1x9gknd 10505 17 in in IN cord-010119-t1x9gknd 10505 18 the the DT cord-010119-t1x9gknd 10505 19 Eastern Eastern NNP cord-010119-t1x9gknd 10505 20 Mediterranean Mediterranean NNP cord-010119-t1x9gknd 10505 21 Region Region NNP cord-010119-t1x9gknd 10505 22 of of IN cord-010119-t1x9gknd 10505 23 the the DT cord-010119-t1x9gknd 10505 24 World World NNP cord-010119-t1x9gknd 10505 25 Health Health NNP cord-010119-t1x9gknd 10505 26 Organization Organization NNP cord-010119-t1x9gknd 10505 27 ( ( -LRB- cord-010119-t1x9gknd 10505 28 WHO who WP cord-010119-t1x9gknd 10505 29 ) ) -RRB- cord-010119-t1x9gknd 10505 30 , , , cord-010119-t1x9gknd 10505 31 where where WRB cord-010119-t1x9gknd 10505 32 some some DT cord-010119-t1x9gknd 10505 33 of of IN cord-010119-t1x9gknd 10505 34 the the DT cord-010119-t1x9gknd 10505 35 most most RBS cord-010119-t1x9gknd 10505 36 affected affected JJ cord-010119-t1x9gknd 10505 37 countries country NNS cord-010119-t1x9gknd 10505 38 in in IN cord-010119-t1x9gknd 10505 39 the the DT cord-010119-t1x9gknd 10505 40 world world NN cord-010119-t1x9gknd 10505 41 are be VBP cord-010119-t1x9gknd 10505 42 located locate VBN cord-010119-t1x9gknd 10505 43 . . . cord-010119-t1x9gknd 10506 1 In in IN cord-010119-t1x9gknd 10506 2 these these DT cord-010119-t1x9gknd 10506 3 countries country NNS cord-010119-t1x9gknd 10506 4 , , , cord-010119-t1x9gknd 10506 5 the the DT cord-010119-t1x9gknd 10506 6 health health NN cord-010119-t1x9gknd 10506 7 systems system NNS cord-010119-t1x9gknd 10506 8 have have VBP cord-010119-t1x9gknd 10506 9 been be VBN cord-010119-t1x9gknd 10506 10 weakened weaken VBN cord-010119-t1x9gknd 10506 11 or or CC cord-010119-t1x9gknd 10506 12 destroyed destroy VBN cord-010119-t1x9gknd 10506 13 and and CC cord-010119-t1x9gknd 10506 14 health health NN cord-010119-t1x9gknd 10506 15 workers worker NNS cord-010119-t1x9gknd 10506 16 provide provide VBP cord-010119-t1x9gknd 10506 17 health health NN cord-010119-t1x9gknd 10506 18 services service NNS cord-010119-t1x9gknd 10506 19 under under IN cord-010119-t1x9gknd 10506 20 difficult difficult JJ cord-010119-t1x9gknd 10506 21 circumstances circumstance NNS cord-010119-t1x9gknd 10506 22 . . . cord-010119-t1x9gknd 10507 1 Humanitarian humanitarian JJ cord-010119-t1x9gknd 10507 2 emergencies emergency NNS cord-010119-t1x9gknd 10507 3 increase increase VBP cord-010119-t1x9gknd 10507 4 the the DT cord-010119-t1x9gknd 10507 5 demand demand NN cord-010119-t1x9gknd 10507 6 for for IN cord-010119-t1x9gknd 10507 7 blood blood NN cord-010119-t1x9gknd 10507 8 transfusion transfusion NN cord-010119-t1x9gknd 10507 9 and and CC cord-010119-t1x9gknd 10507 10 make make VB cord-010119-t1x9gknd 10507 11 its -PRON- PRP$ cord-010119-t1x9gknd 10507 12 delivery delivery NN cord-010119-t1x9gknd 10507 13 challenging challenging JJ cord-010119-t1x9gknd 10507 14 and and CC cord-010119-t1x9gknd 10507 15 complex complex JJ cord-010119-t1x9gknd 10507 16 . . . cord-010119-t1x9gknd 10508 1 Despite despite IN cord-010119-t1x9gknd 10508 2 these these DT cord-010119-t1x9gknd 10508 3 obvious obvious JJ cord-010119-t1x9gknd 10508 4 needs need NNS cord-010119-t1x9gknd 10508 5 , , , cord-010119-t1x9gknd 10508 6 across across IN cord-010119-t1x9gknd 10508 7 the the DT cord-010119-t1x9gknd 10508 8 Region Region NNP cord-010119-t1x9gknd 10508 9 , , , cord-010119-t1x9gknd 10508 10 there there EX cord-010119-t1x9gknd 10508 11 is be VBZ cord-010119-t1x9gknd 10508 12 a a DT cord-010119-t1x9gknd 10508 13 lack lack NN cord-010119-t1x9gknd 10508 14 of of IN cord-010119-t1x9gknd 10508 15 information information NN cord-010119-t1x9gknd 10508 16 on on IN cord-010119-t1x9gknd 10508 17 the the DT cord-010119-t1x9gknd 10508 18 emergency emergency NN cord-010119-t1x9gknd 10508 19 preparedness preparedness NN cord-010119-t1x9gknd 10508 20 and and CC cord-010119-t1x9gknd 10508 21 response response NN cord-010119-t1x9gknd 10508 22 capacity capacity NN cord-010119-t1x9gknd 10508 23 of of IN cord-010119-t1x9gknd 10508 24 blood blood NN cord-010119-t1x9gknd 10508 25 transfusion transfusion NN cord-010119-t1x9gknd 10508 26 and and CC cord-010119-t1x9gknd 10508 27 on on IN cord-010119-t1x9gknd 10508 28 the the DT cord-010119-t1x9gknd 10508 29 challenges challenge NNS cord-010119-t1x9gknd 10508 30 countries country NNS cord-010119-t1x9gknd 10508 31 and and CC cord-010119-t1x9gknd 10508 32 health health NN cord-010119-t1x9gknd 10508 33 responder responder NN cord-010119-t1x9gknd 10508 34 's 's POS cord-010119-t1x9gknd 10508 35 face face NN cord-010119-t1x9gknd 10508 36 in in IN cord-010119-t1x9gknd 10508 37 meeting meet VBG cord-010119-t1x9gknd 10508 38 the the DT cord-010119-t1x9gknd 10508 39 needs need NNS cord-010119-t1x9gknd 10508 40 of of IN cord-010119-t1x9gknd 10508 41 the the DT cord-010119-t1x9gknd 10508 42 patients patient NNS cord-010119-t1x9gknd 10508 43 during during IN cord-010119-t1x9gknd 10508 44 emergencies emergency NNS cord-010119-t1x9gknd 10508 45 . . . cord-010119-t1x9gknd 10509 1 Study Study NNP cord-010119-t1x9gknd 10509 2 Design Design NNP cord-010119-t1x9gknd 10509 3 / / SYM cord-010119-t1x9gknd 10509 4 Method method NN cord-010119-t1x9gknd 10509 5 : : : cord-010119-t1x9gknd 10510 1 We -PRON- PRP cord-010119-t1x9gknd 10510 2 searched search VBD cord-010119-t1x9gknd 10510 3 PubMed PubMed NNP cord-010119-t1x9gknd 10510 4 and and CC cord-010119-t1x9gknd 10510 5 Index Index NNP cord-010119-t1x9gknd 10510 6 Medicus Medicus NNP cord-010119-t1x9gknd 10510 7 for for IN cord-010119-t1x9gknd 10510 8 the the DT cord-010119-t1x9gknd 10510 9 WHO WHO NNP cord-010119-t1x9gknd 10510 10 Eastern Eastern NNP cord-010119-t1x9gknd 10510 11 Mediterranean Mediterranean NNP cord-010119-t1x9gknd 10510 12 Region Region NNP cord-010119-t1x9gknd 10510 13 for for IN cord-010119-t1x9gknd 10510 14 data datum NNS cord-010119-t1x9gknd 10510 15 on on IN cord-010119-t1x9gknd 10510 16 availability availability NN cord-010119-t1x9gknd 10510 17 and and CC cord-010119-t1x9gknd 10510 18 safety safety NN cord-010119-t1x9gknd 10510 19 of of IN cord-010119-t1x9gknd 10510 20 blood blood NN cord-010119-t1x9gknd 10510 21 transfusion transfusion NN cord-010119-t1x9gknd 10510 22 in in IN cord-010119-t1x9gknd 10510 23 humanitarian humanitarian JJ cord-010119-t1x9gknd 10510 24 emergencies emergency NNS cord-010119-t1x9gknd 10510 25 . . . cord-010119-t1x9gknd 10511 1 We -PRON- PRP cord-010119-t1x9gknd 10511 2 conducted conduct VBD cord-010119-t1x9gknd 10511 3 a a DT cord-010119-t1x9gknd 10511 4 structured structured JJ cord-010119-t1x9gknd 10511 5 survey survey NN cord-010119-t1x9gknd 10511 6 of of IN cord-010119-t1x9gknd 10511 7 blood blood NN cord-010119-t1x9gknd 10511 8 transfusion transfusion NN cord-010119-t1x9gknd 10511 9 services service NNS cord-010119-t1x9gknd 10511 10 ( ( -LRB- cord-010119-t1x9gknd 10511 11 BTS BTS NNP cord-010119-t1x9gknd 10511 12 ) ) -RRB- cord-010119-t1x9gknd 10511 13 in in IN cord-010119-t1x9gknd 10511 14 all all DT cord-010119-t1x9gknd 10511 15 countries country NNS cord-010119-t1x9gknd 10511 16 in in IN cord-010119-t1x9gknd 10511 17 the the DT cord-010119-t1x9gknd 10511 18 Region Region NNP cord-010119-t1x9gknd 10511 19 to to TO cord-010119-t1x9gknd 10511 20 identify identify VB cord-010119-t1x9gknd 10511 21 the the DT cord-010119-t1x9gknd 10511 22 following follow VBG cord-010119-t1x9gknd 10511 23 : : : cord-010119-t1x9gknd 10511 24 type type NN cord-010119-t1x9gknd 10511 25 of of IN cord-010119-t1x9gknd 10511 26 humanitarian humanitarian JJ cord-010119-t1x9gknd 10511 27 emergencies emergency NNS cord-010119-t1x9gknd 10511 28 between between IN cord-010119-t1x9gknd 10511 29 2006 2006 CD cord-010119-t1x9gknd 10511 30 and and CC cord-010119-t1x9gknd 10511 31 2016 2016 CD cord-010119-t1x9gknd 10511 32 ; ; , cord-010119-t1x9gknd 10511 33 current current JJ cord-010119-t1x9gknd 10511 34 strategies strategy NNS cord-010119-t1x9gknd 10511 35 to to TO cord-010119-t1x9gknd 10511 36 ensure ensure VB cord-010119-t1x9gknd 10511 37 availability availability NN cord-010119-t1x9gknd 10511 38 and and CC cord-010119-t1x9gknd 10511 39 safety safety NN cord-010119-t1x9gknd 10511 40 of of IN cord-010119-t1x9gknd 10511 41 blood blood NN cord-010119-t1x9gknd 10511 42 transfusion transfusion NN cord-010119-t1x9gknd 10511 43 during during IN cord-010119-t1x9gknd 10511 44 emergencies emergency NNS cord-010119-t1x9gknd 10511 45 ; ; : cord-010119-t1x9gknd 10511 46 coordination coordination NN cord-010119-t1x9gknd 10511 47 and and CC cord-010119-t1x9gknd 10511 48 collaboration collaboration NN cord-010119-t1x9gknd 10511 49 between between IN cord-010119-t1x9gknd 10511 50 countries country NNS cord-010119-t1x9gknd 10511 51 ; ; : cord-010119-t1x9gknd 10511 52 and and CC cord-010119-t1x9gknd 10511 53 gaps gap NNS cord-010119-t1x9gknd 10511 54 and and CC cord-010119-t1x9gknd 10511 55 challenges challenge NNS cord-010119-t1x9gknd 10511 56 . . . cord-010119-t1x9gknd 10512 1 Additional additional JJ cord-010119-t1x9gknd 10512 2 information information NN cord-010119-t1x9gknd 10512 3 was be VBD cord-010119-t1x9gknd 10512 4 collected collect VBN cord-010119-t1x9gknd 10512 5 during during IN cord-010119-t1x9gknd 10512 6 a a DT cord-010119-t1x9gknd 10512 7 regional regional JJ cord-010119-t1x9gknd 10512 8 consultation consultation NN cord-010119-t1x9gknd 10512 9 ( ( -LRB- cord-010119-t1x9gknd 10512 10 Eastern Eastern NNP cord-010119-t1x9gknd 10512 11 Mediterranean Mediterranean NNP cord-010119-t1x9gknd 10512 12 Region Region NNP cord-010119-t1x9gknd 10512 13 ) ) -RRB- cord-010119-t1x9gknd 10512 14 held hold VBN cord-010119-t1x9gknd 10512 15 in in IN cord-010119-t1x9gknd 10512 16 May May NNP cord-010119-t1x9gknd 10512 17 2016 2016 CD cord-010119-t1x9gknd 10512 18 in in IN cord-010119-t1x9gknd 10512 19 Tunisia Tunisia NNP cord-010119-t1x9gknd 10512 20 . . . cord-010119-t1x9gknd 10513 1 Results/ Results/ . cord-010119-t1x9gknd 10514 1 Finding find VBG cord-010119-t1x9gknd 10515 1 : : : cord-010119-t1x9gknd 10515 2 We -PRON- PRP cord-010119-t1x9gknd 10515 3 found find VBD cord-010119-t1x9gknd 10515 4 24 24 CD cord-010119-t1x9gknd 10515 5 publications publication NNS cord-010119-t1x9gknd 10515 6 on on IN cord-010119-t1x9gknd 10515 7 disaster disaster NN cord-010119-t1x9gknd 10515 8 from from IN cord-010119-t1x9gknd 10515 9 five five CD cord-010119-t1x9gknd 10515 10 countries country NNS cord-010119-t1x9gknd 10515 11 in in IN cord-010119-t1x9gknd 10515 12 the the DT cord-010119-t1x9gknd 10515 13 Region Region NNP cord-010119-t1x9gknd 10515 14 and and CC cord-010119-t1x9gknd 10515 15 16 16 CD cord-010119-t1x9gknd 10515 16 publications publication NNS cord-010119-t1x9gknd 10515 17 on on IN cord-010119-t1x9gknd 10515 18 disaster disaster NN cord-010119-t1x9gknd 10515 19 preparedness preparedness NN cord-010119-t1x9gknd 10515 20 and and CC cord-010119-t1x9gknd 10515 21 blood blood NN cord-010119-t1x9gknd 10515 22 transfusion transfusion NN cord-010119-t1x9gknd 10515 23 in in IN cord-010119-t1x9gknd 10515 24 casualties casualty NNS cord-010119-t1x9gknd 10515 25 and and CC cord-010119-t1x9gknd 10515 26 severe severe JJ cord-010119-t1x9gknd 10515 27 trauma trauma NN cord-010119-t1x9gknd 10515 28 outside outside IN cord-010119-t1x9gknd 10515 29 the the DT cord-010119-t1x9gknd 10515 30 Region Region NNP cord-010119-t1x9gknd 10515 31 . . . cord-010119-t1x9gknd 10516 1 However however RB cord-010119-t1x9gknd 10516 2 , , , cord-010119-t1x9gknd 10516 3 none none NN cord-010119-t1x9gknd 10516 4 dealt deal VBD cord-010119-t1x9gknd 10516 5 with with IN cord-010119-t1x9gknd 10516 6 the the DT cord-010119-t1x9gknd 10516 7 questions question NNS cord-010119-t1x9gknd 10516 8 of of IN cord-010119-t1x9gknd 10516 9 availability availability NN cord-010119-t1x9gknd 10516 10 and and CC cord-010119-t1x9gknd 10516 11 safety safety NN cord-010119-t1x9gknd 10516 12 of of IN cord-010119-t1x9gknd 10516 13 blood blood NN cord-010119-t1x9gknd 10516 14 transfusion transfusion NN cord-010119-t1x9gknd 10516 15 during during IN cord-010119-t1x9gknd 10516 16 emergencies emergency NNS cord-010119-t1x9gknd 10516 17 . . . cord-010119-t1x9gknd 10517 1 Twelve twelve CD cord-010119-t1x9gknd 10517 2 countries country NNS cord-010119-t1x9gknd 10517 3 ( ( -LRB- cord-010119-t1x9gknd 10517 4 54.5 54.5 CD cord-010119-t1x9gknd 10517 5 % % NN cord-010119-t1x9gknd 10517 6 ) ) -RRB- cord-010119-t1x9gknd 10517 7 responded respond VBD cord-010119-t1x9gknd 10517 8 to to IN cord-010119-t1x9gknd 10517 9 the the DT cord-010119-t1x9gknd 10517 10 survey survey NN cord-010119-t1x9gknd 10517 11 . . . cord-010119-t1x9gknd 10518 1 Armed armed JJ cord-010119-t1x9gknd 10518 2 conflicts conflict NNS cord-010119-t1x9gknd 10518 3 and and CC cord-010119-t1x9gknd 10518 4 terrorism terrorism NN cord-010119-t1x9gknd 10518 5 are be VBP cord-010119-t1x9gknd 10518 6 the the DT cord-010119-t1x9gknd 10518 7 commonest common JJS cord-010119-t1x9gknd 10518 8 types type NNS cord-010119-t1x9gknd 10518 9 of of IN cord-010119-t1x9gknd 10518 10 emergencies emergency NNS cord-010119-t1x9gknd 10518 11 with with IN cord-010119-t1x9gknd 10518 12 estimated estimate VBN cord-010119-t1x9gknd 10518 13 10 10 CD cord-010119-t1x9gknd 10518 14 - - SYM cord-010119-t1x9gknd 10518 15 85 85 CD cord-010119-t1x9gknd 10518 16 % % NN cord-010119-t1x9gknd 10518 17 of of IN cord-010119-t1x9gknd 10518 18 the the DT cord-010119-t1x9gknd 10518 19 injured injure VBN cord-010119-t1x9gknd 10518 20 requiring require VBG cord-010119-t1x9gknd 10518 21 blood blood NN cord-010119-t1x9gknd 10518 22 transfusion transfusion NN cord-010119-t1x9gknd 10518 23 . . . cord-010119-t1x9gknd 10519 1 Nine nine CD cord-010119-t1x9gknd 10519 2 countries country NNS cord-010119-t1x9gknd 10519 3 have have VBP cord-010119-t1x9gknd 10519 4 emergency emergency NN cord-010119-t1x9gknd 10519 5 preparedness preparedness NN cord-010119-t1x9gknd 10519 6 and and CC cord-010119-t1x9gknd 10519 7 response response NN cord-010119-t1x9gknd 10519 8 plans plan NNS cord-010119-t1x9gknd 10519 9 for for IN cord-010119-t1x9gknd 10519 10 BTS BTS NNP cord-010119-t1x9gknd 10519 11 . . . cord-010119-t1x9gknd 10520 1 Potential potential JJ cord-010119-t1x9gknd 10520 2 blood blood NN cord-010119-t1x9gknd 10520 3 donors donor NNS cord-010119-t1x9gknd 10520 4 are be VBP cord-010119-t1x9gknd 10520 5 mobilized mobilize VBN cord-010119-t1x9gknd 10520 6 through through IN cord-010119-t1x9gknd 10520 7 public public JJ cord-010119-t1x9gknd 10520 8 calls call NNS cord-010119-t1x9gknd 10520 9 , , , cord-010119-t1x9gknd 10520 10 besides besides IN cord-010119-t1x9gknd 10520 11 a a DT cord-010119-t1x9gknd 10520 12 direct direct JJ cord-010119-t1x9gknd 10520 13 appeal appeal NN cord-010119-t1x9gknd 10520 14 on on IN cord-010119-t1x9gknd 10520 15 regular regular JJ cord-010119-t1x9gknd 10520 16 and and CC cord-010119-t1x9gknd 10520 17 replacement replacement NN cord-010119-t1x9gknd 10520 18 donors donor NNS cord-010119-t1x9gknd 10520 19 . . . cord-010119-t1x9gknd 10521 1 Seven seven CD cord-010119-t1x9gknd 10521 2 of of IN cord-010119-t1x9gknd 10521 3 the the DT cord-010119-t1x9gknd 10521 4 responding respond VBG cord-010119-t1x9gknd 10521 5 countries country NNS cord-010119-t1x9gknd 10521 6 keep keep VBP cord-010119-t1x9gknd 10521 7 an an DT cord-010119-t1x9gknd 10521 8 emergency emergency NN cord-010119-t1x9gknd 10521 9 blood blood NN cord-010119-t1x9gknd 10521 10 stock stock NN cord-010119-t1x9gknd 10521 11 . . . cord-010119-t1x9gknd 10522 1 Collaboration collaboration NN cord-010119-t1x9gknd 10522 2 between between IN cord-010119-t1x9gknd 10522 3 the the DT cord-010119-t1x9gknd 10522 4 different different JJ cord-010119-t1x9gknd 10522 5 stakeholders stakeholder NNS cord-010119-t1x9gknd 10522 6 exists exist VBZ cord-010119-t1x9gknd 10522 7 in in IN cord-010119-t1x9gknd 10522 8 seven seven CD cord-010119-t1x9gknd 10522 9 countries country NNS cord-010119-t1x9gknd 10522 10 . . . cord-010119-t1x9gknd 10523 1 Lack lack NN cord-010119-t1x9gknd 10523 2 of of IN cord-010119-t1x9gknd 10523 3 adequate adequate JJ cord-010119-t1x9gknd 10523 4 and and CC cord-010119-t1x9gknd 10523 5 competent competent JJ cord-010119-t1x9gknd 10523 6 human human JJ cord-010119-t1x9gknd 10523 7 resource resource NN cord-010119-t1x9gknd 10523 8 , , , cord-010119-t1x9gknd 10523 9 transport transport NN cord-010119-t1x9gknd 10523 10 and and CC cord-010119-t1x9gknd 10523 11 cold cold JJ cord-010119-t1x9gknd 10523 12 chain chain NN cord-010119-t1x9gknd 10523 13 deficits deficit NNS cord-010119-t1x9gknd 10523 14 , , , cord-010119-t1x9gknd 10523 15 shortages shortage NNS cord-010119-t1x9gknd 10523 16 in in IN cord-010119-t1x9gknd 10523 17 supply supply NN cord-010119-t1x9gknd 10523 18 of of IN cord-010119-t1x9gknd 10523 19 consumables consumable NNS cord-010119-t1x9gknd 10523 20 and and CC cord-010119-t1x9gknd 10523 21 maintenance maintenance NN cord-010119-t1x9gknd 10523 22 of of IN cord-010119-t1x9gknd 10523 23 equipment equipment NN cord-010119-t1x9gknd 10523 24 , , , cord-010119-t1x9gknd 10523 25 lack lack NN cord-010119-t1x9gknd 10523 26 of of IN cord-010119-t1x9gknd 10523 27 reliable reliable JJ cord-010119-t1x9gknd 10523 28 power power NN cord-010119-t1x9gknd 10523 29 supply supply NN cord-010119-t1x9gknd 10523 30 , , , cord-010119-t1x9gknd 10523 31 and and CC cord-010119-t1x9gknd 10523 32 shortage shortage NN cord-010119-t1x9gknd 10523 33 in in IN cord-010119-t1x9gknd 10523 34 finances finance NNS cord-010119-t1x9gknd 10523 35 are be VBP cord-010119-t1x9gknd 10523 36 the the DT cord-010119-t1x9gknd 10523 37 gaps gap NNS cord-010119-t1x9gknd 10523 38 identified identify VBN cord-010119-t1x9gknd 10523 39 . . . cord-010119-t1x9gknd 10524 1 Conclusion conclusion NN cord-010119-t1x9gknd 10524 2 : : : cord-010119-t1x9gknd 10524 3 There there EX cord-010119-t1x9gknd 10524 4 is be VBZ cord-010119-t1x9gknd 10524 5 a a DT cord-010119-t1x9gknd 10524 6 need need NN cord-010119-t1x9gknd 10524 7 to to TO cord-010119-t1x9gknd 10524 8 integrate integrate VB cord-010119-t1x9gknd 10524 9 BTS BTS NNP cord-010119-t1x9gknd 10524 10 in in IN cord-010119-t1x9gknd 10524 11 the the DT cord-010119-t1x9gknd 10524 12 overall overall JJ cord-010119-t1x9gknd 10524 13 national national JJ cord-010119-t1x9gknd 10524 14 emergency emergency NN cord-010119-t1x9gknd 10524 15 preparedness preparedness NN cord-010119-t1x9gknd 10524 16 and and CC cord-010119-t1x9gknd 10524 17 response response NN cord-010119-t1x9gknd 10524 18 , , , cord-010119-t1x9gknd 10524 19 collect collect VB cord-010119-t1x9gknd 10524 20 and and CC cord-010119-t1x9gknd 10524 21 disseminate disseminate VB cord-010119-t1x9gknd 10524 22 updated update VBN cord-010119-t1x9gknd 10524 23 information information NN cord-010119-t1x9gknd 10524 24 on on IN cord-010119-t1x9gknd 10524 25 factors factor NNS cord-010119-t1x9gknd 10524 26 affecting affect VBG cord-010119-t1x9gknd 10524 27 provision provision NN cord-010119-t1x9gknd 10524 28 of of IN cord-010119-t1x9gknd 10524 29 blood blood NN cord-010119-t1x9gknd 10524 30 transfusion transfusion NN cord-010119-t1x9gknd 10524 31 in in IN cord-010119-t1x9gknd 10524 32 humanitarian humanitarian JJ cord-010119-t1x9gknd 10524 33 emergencies emergency NNS cord-010119-t1x9gknd 10524 34 , , , cord-010119-t1x9gknd 10524 35 provide provide VB cord-010119-t1x9gknd 10524 36 technical technical JJ cord-010119-t1x9gknd 10524 37 and and CC cord-010119-t1x9gknd 10524 38 financial financial JJ cord-010119-t1x9gknd 10524 39 assistance assistance NN cord-010119-t1x9gknd 10524 40 to to IN cord-010119-t1x9gknd 10524 41 affected affected JJ cord-010119-t1x9gknd 10524 42 countries country NNS cord-010119-t1x9gknd 10524 43 , , , cord-010119-t1x9gknd 10524 44 strengthen strengthen VB cord-010119-t1x9gknd 10524 45 mechanisms mechanism NNS cord-010119-t1x9gknd 10524 46 for for IN cord-010119-t1x9gknd 10524 47 coordination coordination NN cord-010119-t1x9gknd 10524 48 and and CC cord-010119-t1x9gknd 10524 49 collaboration collaboration NN cord-010119-t1x9gknd 10524 50 among among IN cord-010119-t1x9gknd 10524 51 different different JJ cord-010119-t1x9gknd 10524 52 parties party NNS cord-010119-t1x9gknd 10524 53 , , , cord-010119-t1x9gknd 10524 54 and and CC cord-010119-t1x9gknd 10524 55 develop develop VB cord-010119-t1x9gknd 10524 56 a a DT cord-010119-t1x9gknd 10524 57 regional regional JJ cord-010119-t1x9gknd 10524 58 emergency emergency NN cord-010119-t1x9gknd 10524 59 blood blood NN cord-010119-t1x9gknd 10524 60 services service NNS cord-010119-t1x9gknd 10524 61 system system NN cord-010119-t1x9gknd 10524 62 and and CC cord-010119-t1x9gknd 10524 63 management management NN cord-010119-t1x9gknd 10524 64 expertise expertise NN cord-010119-t1x9gknd 10524 65 . . . cord-010119-t1x9gknd 10525 1 ( ( -LRB- cord-010119-t1x9gknd 10525 2 63 63 CD cord-010119-t1x9gknd 10525 3 , , , cord-010119-t1x9gknd 10525 4 85 85 CD cord-010119-t1x9gknd 10525 5 , , , cord-010119-t1x9gknd 10525 6 and and CC cord-010119-t1x9gknd 10525 7 108 108 CD cord-010119-t1x9gknd 10525 8 for for IN cord-010119-t1x9gknd 10525 9 2014 2014 CD cord-010119-t1x9gknd 10525 10 - - HYPH cord-010119-t1x9gknd 10525 11 2016 2016 CD cord-010119-t1x9gknd 10525 12 ) ) -RRB- cord-010119-t1x9gknd 10525 13 . . . cord-010119-t1x9gknd 10526 1 The the DT cord-010119-t1x9gknd 10526 2 number number NN cord-010119-t1x9gknd 10526 3 of of IN cord-010119-t1x9gknd 10526 4 collections collection NNS cord-010119-t1x9gknd 10526 5 per per IN cord-010119-t1x9gknd 10526 6 registered register VBN cord-010119-t1x9gknd 10526 7 TRT trt NN cord-010119-t1x9gknd 10526 8 donor donor NN cord-010119-t1x9gknd 10526 9 varied vary VBN cord-010119-t1x9gknd 10526 10 significantly significantly RB cord-010119-t1x9gknd 10526 11 , , , cord-010119-t1x9gknd 10526 12 ranging range VBG cord-010119-t1x9gknd 10526 13 from from IN cord-010119-t1x9gknd 10526 14 0 0 CD cord-010119-t1x9gknd 10526 15 to to IN cord-010119-t1x9gknd 10526 16 12 12 CD cord-010119-t1x9gknd 10526 17 therapeutic therapeutic JJ cord-010119-t1x9gknd 10526 18 draws draw NNS cord-010119-t1x9gknd 10526 19 / / SYM cord-010119-t1x9gknd 10526 20 donor donor NN cord-010119-t1x9gknd 10526 21 per per IN cord-010119-t1x9gknd 10526 22 year year NN cord-010119-t1x9gknd 10526 23 . . . cord-010119-t1x9gknd 10527 1 Excluding exclude VBG cord-010119-t1x9gknd 10527 2 those those DT cord-010119-t1x9gknd 10527 3 that that WDT cord-010119-t1x9gknd 10527 4 did do VBD cord-010119-t1x9gknd 10527 5 n't not RB cord-010119-t1x9gknd 10527 6 present present VB cord-010119-t1x9gknd 10527 7 for for IN cord-010119-t1x9gknd 10527 8 a a DT cord-010119-t1x9gknd 10527 9 therapeutic therapeutic JJ cord-010119-t1x9gknd 10527 10 blood blood NN cord-010119-t1x9gknd 10527 11 collection collection NN cord-010119-t1x9gknd 10527 12 , , , cord-010119-t1x9gknd 10527 13 the the DT cord-010119-t1x9gknd 10527 14 average average JJ cord-010119-t1x9gknd 10527 15 number number NN cord-010119-t1x9gknd 10527 16 of of IN cord-010119-t1x9gknd 10527 17 TRT TRT NNP cord-010119-t1x9gknd 10527 18 collections collection NNS cord-010119-t1x9gknd 10527 19 / / SYM cord-010119-t1x9gknd 10527 20 donor donor NN cord-010119-t1x9gknd 10527 21 per per IN cord-010119-t1x9gknd 10527 22 year year NN cord-010119-t1x9gknd 10527 23 decreased decrease VBD cord-010119-t1x9gknd 10527 24 from from IN cord-010119-t1x9gknd 10527 25 3.8 3.8 CD cord-010119-t1x9gknd 10527 26 to to IN cord-010119-t1x9gknd 10527 27 2.8 2.8 CD cord-010119-t1x9gknd 10527 28 between between IN cord-010119-t1x9gknd 10527 29 2014 2014 CD cord-010119-t1x9gknd 10527 30 and and CC cord-010119-t1x9gknd 10527 31 2016 2016 CD cord-010119-t1x9gknd 10527 32 . . . cord-010119-t1x9gknd 10528 1 Conclusion conclusion NN cord-010119-t1x9gknd 10528 2 : : : cord-010119-t1x9gknd 10529 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10529 2 blood blood NN cord-010119-t1x9gknd 10529 3 center center NN cord-010119-t1x9gknd 10529 4 has have VBZ cord-010119-t1x9gknd 10529 5 experienced experience VBN cord-010119-t1x9gknd 10529 6 an an DT cord-010119-t1x9gknd 10529 7 increasing increase VBG cord-010119-t1x9gknd 10529 8 number number NN cord-010119-t1x9gknd 10529 9 of of IN cord-010119-t1x9gknd 10529 10 therapeutic therapeutic JJ cord-010119-t1x9gknd 10529 11 phlebotomies phlebotomy NNS cord-010119-t1x9gknd 10529 12 , , , cord-010119-t1x9gknd 10529 13 as as RB cord-010119-t1x9gknd 10529 14 well well RB cord-010119-t1x9gknd 10529 15 as as IN cord-010119-t1x9gknd 10529 16 individuals individual NNS cord-010119-t1x9gknd 10529 17 on on IN cord-010119-t1x9gknd 10529 18 TRT TRT NNP cord-010119-t1x9gknd 10529 19 referred refer VBD cord-010119-t1x9gknd 10529 20 for for IN cord-010119-t1x9gknd 10529 21 therapeutic therapeutic JJ cord-010119-t1x9gknd 10529 22 phlebotomy phlebotomy NN cord-010119-t1x9gknd 10529 23 due due IN cord-010119-t1x9gknd 10529 24 to to IN cord-010119-t1x9gknd 10529 25 elevated elevated JJ cord-010119-t1x9gknd 10529 26 hemoglobin hemoglobin NN cord-010119-t1x9gknd 10529 27 values value NNS cord-010119-t1x9gknd 10529 28 from from IN cord-010119-t1x9gknd 10529 29 2014 2014 CD cord-010119-t1x9gknd 10529 30 through through IN cord-010119-t1x9gknd 10529 31 2016 2016 CD cord-010119-t1x9gknd 10529 32 . . . cord-010119-t1x9gknd 10530 1 It -PRON- PRP cord-010119-t1x9gknd 10530 2 is be VBZ cord-010119-t1x9gknd 10530 3 not not RB cord-010119-t1x9gknd 10530 4 clear clear JJ cord-010119-t1x9gknd 10530 5 from from IN cord-010119-t1x9gknd 10530 6 information information NN cord-010119-t1x9gknd 10530 7 provided provide VBN cord-010119-t1x9gknd 10530 8 by by IN cord-010119-t1x9gknd 10530 9 the the DT cord-010119-t1x9gknd 10530 10 ordering order VBG cord-010119-t1x9gknd 10530 11 physician physician NN cord-010119-t1x9gknd 10530 12 whether whether IN cord-010119-t1x9gknd 10530 13 this this DT cord-010119-t1x9gknd 10530 14 is be VBZ cord-010119-t1x9gknd 10530 15 intended intend VBN cord-010119-t1x9gknd 10530 16 as as IN cord-010119-t1x9gknd 10530 17 a a DT cord-010119-t1x9gknd 10530 18 temporary temporary JJ cord-010119-t1x9gknd 10530 19 measure measure NN cord-010119-t1x9gknd 10530 20 to to TO cord-010119-t1x9gknd 10530 21 decrease decrease VB cord-010119-t1x9gknd 10530 22 the the DT cord-010119-t1x9gknd 10530 23 hemoglobin hemoglobin NN cord-010119-t1x9gknd 10530 24 while while IN cord-010119-t1x9gknd 10530 25 the the DT cord-010119-t1x9gknd 10530 26 patient patient NN cord-010119-t1x9gknd 10530 27 is be VBZ cord-010119-t1x9gknd 10530 28 on on IN cord-010119-t1x9gknd 10530 29 TRT TRT NNP cord-010119-t1x9gknd 10530 30 , , , cord-010119-t1x9gknd 10530 31 or or CC cord-010119-t1x9gknd 10530 32 whether whether IN cord-010119-t1x9gknd 10530 33 the the DT cord-010119-t1x9gknd 10530 34 dose dose NN cord-010119-t1x9gknd 10530 35 was be VBD cord-010119-t1x9gknd 10530 36 being be VBG cord-010119-t1x9gknd 10530 37 adjusted adjust VBN cord-010119-t1x9gknd 10530 38 or or CC cord-010119-t1x9gknd 10530 39 discontinued discontinue VBN cord-010119-t1x9gknd 10530 40 due due IN cord-010119-t1x9gknd 10530 41 to to IN cord-010119-t1x9gknd 10530 42 the the DT cord-010119-t1x9gknd 10530 43 known know VBN cord-010119-t1x9gknd 10530 44 risk risk NN cord-010119-t1x9gknd 10530 45 factor factor NN cord-010119-t1x9gknd 10530 46 of of IN cord-010119-t1x9gknd 10530 47 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 10530 48 disease disease NN cord-010119-t1x9gknd 10530 49 in in IN cord-010119-t1x9gknd 10530 50 patients patient NNS cord-010119-t1x9gknd 10530 51 with with IN cord-010119-t1x9gknd 10530 52 polycythemia polycythemia NN cord-010119-t1x9gknd 10530 53 ; ; : cord-010119-t1x9gknd 10530 54 however however RB cord-010119-t1x9gknd 10530 55 , , , cord-010119-t1x9gknd 10530 56 the the DT cord-010119-t1x9gknd 10530 57 average average JJ cord-010119-t1x9gknd 10530 58 number number NN cord-010119-t1x9gknd 10530 59 of of IN cord-010119-t1x9gknd 10530 60 donations donation NNS cord-010119-t1x9gknd 10530 61 per per IN cord-010119-t1x9gknd 10530 62 TRT TRT NNP cord-010119-t1x9gknd 10530 63 donor donor NN cord-010119-t1x9gknd 10530 64 decreased decrease VBD cord-010119-t1x9gknd 10530 65 during during IN cord-010119-t1x9gknd 10530 66 this this DT cord-010119-t1x9gknd 10530 67 timeframe timeframe NN cord-010119-t1x9gknd 10530 68 . . . cord-010119-t1x9gknd 10531 1 The the DT cord-010119-t1x9gknd 10531 2 percentage percentage NN cord-010119-t1x9gknd 10531 3 of of IN cord-010119-t1x9gknd 10531 4 men man NNS cord-010119-t1x9gknd 10531 5 on on IN cord-010119-t1x9gknd 10531 6 testosterone testosterone NN cord-010119-t1x9gknd 10531 7 who who WP cord-010119-t1x9gknd 10531 8 present present VBP cord-010119-t1x9gknd 10531 9 as as IN cord-010119-t1x9gknd 10531 10 regular regular JJ cord-010119-t1x9gknd 10531 11 blood blood NN cord-010119-t1x9gknd 10531 12 donors donor NNS cord-010119-t1x9gknd 10531 13 at at IN cord-010119-t1x9gknd 10531 14 our -PRON- PRP$ cord-010119-t1x9gknd 10531 15 blood blood NN cord-010119-t1x9gknd 10531 16 center center NN cord-010119-t1x9gknd 10531 17 is be VBZ cord-010119-t1x9gknd 10531 18 not not RB cord-010119-t1x9gknd 10531 19 known know VBN cord-010119-t1x9gknd 10531 20 , , , cord-010119-t1x9gknd 10531 21 since since IN cord-010119-t1x9gknd 10531 22 this this DT cord-010119-t1x9gknd 10531 23 hormone hormone NN cord-010119-t1x9gknd 10531 24 is be VBZ cord-010119-t1x9gknd 10531 25 not not RB cord-010119-t1x9gknd 10531 26 reason reason NN cord-010119-t1x9gknd 10531 27 for for IN cord-010119-t1x9gknd 10531 28 deferral deferral NN cord-010119-t1x9gknd 10531 29 . . . cord-010119-t1x9gknd 10532 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10532 2 findings finding NNS cord-010119-t1x9gknd 10532 3 raise raise VBP cord-010119-t1x9gknd 10532 4 the the DT cord-010119-t1x9gknd 10532 5 concern concern NN cord-010119-t1x9gknd 10532 6 , , , cord-010119-t1x9gknd 10532 7 however however RB cord-010119-t1x9gknd 10532 8 , , , cord-010119-t1x9gknd 10532 9 that that IN cord-010119-t1x9gknd 10532 10 regular regular JJ cord-010119-t1x9gknd 10532 11 phlebotomy phlebotomy NN cord-010119-t1x9gknd 10532 12 is be VBZ cord-010119-t1x9gknd 10532 13 necessary necessary JJ cord-010119-t1x9gknd 10532 14 to to TO cord-010119-t1x9gknd 10532 15 reduce reduce VB cord-010119-t1x9gknd 10532 16 the the DT cord-010119-t1x9gknd 10532 17 risk risk NN cord-010119-t1x9gknd 10532 18 of of IN cord-010119-t1x9gknd 10532 19 testosterone testosterone NN cord-010119-t1x9gknd 10532 20 - - HYPH cord-010119-t1x9gknd 10532 21 associated associate VBN cord-010119-t1x9gknd 10532 22 polycythemia polycythemia NN cord-010119-t1x9gknd 10532 23 in in IN cord-010119-t1x9gknd 10532 24 this this DT cord-010119-t1x9gknd 10532 25 population population NN cord-010119-t1x9gknd 10532 26 . . . cord-010119-t1x9gknd 10533 1 As as IN cord-010119-t1x9gknd 10533 2 it -PRON- PRP cord-010119-t1x9gknd 10533 3 is be VBZ cord-010119-t1x9gknd 10533 4 our -PRON- PRP$ cord-010119-t1x9gknd 10533 5 duty duty NN cord-010119-t1x9gknd 10533 6 to to TO cord-010119-t1x9gknd 10533 7 provide provide VB cord-010119-t1x9gknd 10533 8 a a DT cord-010119-t1x9gknd 10533 9 safe safe JJ cord-010119-t1x9gknd 10533 10 and and CC cord-010119-t1x9gknd 10533 11 adequate adequate JJ cord-010119-t1x9gknd 10533 12 blood blood NN cord-010119-t1x9gknd 10533 13 supply supply NN cord-010119-t1x9gknd 10533 14 , , , cord-010119-t1x9gknd 10533 15 our -PRON- PRP$ cord-010119-t1x9gknd 10533 16 blood blood NN cord-010119-t1x9gknd 10533 17 center center NN cord-010119-t1x9gknd 10533 18 also also RB cord-010119-t1x9gknd 10533 19 has have VBZ cord-010119-t1x9gknd 10533 20 concerns concern NNS cord-010119-t1x9gknd 10533 21 about about IN cord-010119-t1x9gknd 10533 22 perpetuating perpetuate VBG cord-010119-t1x9gknd 10533 23 the the DT cord-010119-t1x9gknd 10533 24 misperception misperception NN cord-010119-t1x9gknd 10533 25 that that WDT cord-010119-t1x9gknd 10533 26 repeat repeat NN cord-010119-t1x9gknd 10533 27 phlebotomy phlebotomy NN cord-010119-t1x9gknd 10533 28 , , , cord-010119-t1x9gknd 10533 29 particularly particularly RB cord-010119-t1x9gknd 10533 30 if if IN cord-010119-t1x9gknd 10533 31 required require VBN cord-010119-t1x9gknd 10533 32 more more RBR cord-010119-t1x9gknd 10533 33 frequently frequently RB cord-010119-t1x9gknd 10533 34 than than IN cord-010119-t1x9gknd 10533 35 56 56 CD cord-010119-t1x9gknd 10533 36 days day NNS cord-010119-t1x9gknd 10533 37 , , , cord-010119-t1x9gknd 10533 38 is be VBZ cord-010119-t1x9gknd 10533 39 sufficient sufficient JJ cord-010119-t1x9gknd 10533 40 to to TO cord-010119-t1x9gknd 10533 41 mitigate mitigate VB cord-010119-t1x9gknd 10533 42 the the DT cord-010119-t1x9gknd 10533 43 risks risk NNS cord-010119-t1x9gknd 10533 44 of of IN cord-010119-t1x9gknd 10533 45 testosterone testosterone NN cord-010119-t1x9gknd 10533 46 therapy therapy NN cord-010119-t1x9gknd 10533 47 . . . cord-010119-t1x9gknd 10534 1 Hence hence RB cord-010119-t1x9gknd 10534 2 , , , cord-010119-t1x9gknd 10534 3 we -PRON- PRP cord-010119-t1x9gknd 10534 4 have have VBP cord-010119-t1x9gknd 10534 5 made make VBN cord-010119-t1x9gknd 10534 6 the the DT cord-010119-t1x9gknd 10534 7 decision decision NN cord-010119-t1x9gknd 10534 8 to to TO cord-010119-t1x9gknd 10534 9 discontinue discontinue VB cord-010119-t1x9gknd 10534 10 offering offer VBG cord-010119-t1x9gknd 10534 11 phlebotomy phlebotomy NN cord-010119-t1x9gknd 10534 12 services service NNS cord-010119-t1x9gknd 10534 13 to to IN cord-010119-t1x9gknd 10534 14 this this DT cord-010119-t1x9gknd 10534 15 population population NN cord-010119-t1x9gknd 10534 16 of of IN cord-010119-t1x9gknd 10534 17 donors donor NNS cord-010119-t1x9gknd 10534 18 other other JJ cord-010119-t1x9gknd 10534 19 than than IN cord-010119-t1x9gknd 10534 20 for for IN cord-010119-t1x9gknd 10534 21 those those DT cord-010119-t1x9gknd 10534 22 on on IN cord-010119-t1x9gknd 10534 23 testosterone testosterone NN cord-010119-t1x9gknd 10534 24 that that WDT cord-010119-t1x9gknd 10534 25 meet meet VBP cord-010119-t1x9gknd 10534 26 all all DT cord-010119-t1x9gknd 10534 27 donor donor NN cord-010119-t1x9gknd 10534 28 eligibility eligibility NN cord-010119-t1x9gknd 10534 29 requirements requirement NNS cord-010119-t1x9gknd 10534 30 . . . cord-010119-t1x9gknd 10535 1 Approaches approach NNS cord-010119-t1x9gknd 10535 2 Involving involve VBG cord-010119-t1x9gknd 10535 3 the the DT cord-010119-t1x9gknd 10535 4 Use Use NNP cord-010119-t1x9gknd 10535 5 of of IN cord-010119-t1x9gknd 10535 6 a a DT cord-010119-t1x9gknd 10535 7 Vein Vein NNP cord-010119-t1x9gknd 10535 8 Illumination Illumination NNP cord-010119-t1x9gknd 10535 9 Device device NN cord-010119-t1x9gknd 10535 10 in in IN cord-010119-t1x9gknd 10535 11 a a DT cord-010119-t1x9gknd 10535 12 Blood Blood NNP cord-010119-t1x9gknd 10535 13 Donor Donor NNP cord-010119-t1x9gknd 10535 14 Center Center NNP cord-010119-t1x9gknd 10535 15 Sara Sara NNP cord-010119-t1x9gknd 10535 16 Matheson Matheson NNP cord-010119-t1x9gknd 10535 17 * * NFP cord-010119-t1x9gknd 10535 18 , , , cord-010119-t1x9gknd 10535 19 Kimberly Kimberly NNP cord-010119-t1x9gknd 10535 20 J J NNP cord-010119-t1x9gknd 10535 21 Duffy Duffy NNP cord-010119-t1x9gknd 10535 22 , , , cord-010119-t1x9gknd 10535 23 Audrey Audrey NNP cord-010119-t1x9gknd 10535 24 E E NNP cord-010119-t1x9gknd 10535 25 Traun Traun NNP cord-010119-t1x9gknd 10535 26 , , , cord-010119-t1x9gknd 10535 27 Mary Mary NNP cord-010119-t1x9gknd 10535 28 M M NNP cord-010119-t1x9gknd 10535 29 Benike Benike NNP cord-010119-t1x9gknd 10535 30 , , , cord-010119-t1x9gknd 10535 31 James James NNP cord-010119-t1x9gknd 10535 32 R R NNP cord-010119-t1x9gknd 10535 33 Stubbs Stubbs NNP cord-010119-t1x9gknd 10535 34 and and CC cord-010119-t1x9gknd 10535 35 Justin Justin NNP cord-010119-t1x9gknd 10535 36 D D NNP cord-010119-t1x9gknd 10535 37 Kreuter Kreuter NNP cord-010119-t1x9gknd 10535 38 . . . cord-010119-t1x9gknd 10536 1 Mayo Mayo NNP cord-010119-t1x9gknd 10536 2 Clinic Clinic NNP cord-010119-t1x9gknd 10536 3 Background Background NNP cord-010119-t1x9gknd 10536 4 / / SYM cord-010119-t1x9gknd 10536 5 Case Case NNP cord-010119-t1x9gknd 10536 6 Studies Studies NNPS cord-010119-t1x9gknd 10537 1 : : : cord-010119-t1x9gknd 10537 2 Venipuncture Venipuncture NNP cord-010119-t1x9gknd 10537 3 is be VBZ cord-010119-t1x9gknd 10537 4 a a DT cord-010119-t1x9gknd 10537 5 critical critical JJ cord-010119-t1x9gknd 10537 6 step step NN cord-010119-t1x9gknd 10537 7 in in IN cord-010119-t1x9gknd 10537 8 blood blood NN cord-010119-t1x9gknd 10537 9 collection collection NN cord-010119-t1x9gknd 10537 10 and and CC cord-010119-t1x9gknd 10537 11 locating locate VBG cord-010119-t1x9gknd 10537 12 a a DT cord-010119-t1x9gknd 10537 13 suitable suitable JJ cord-010119-t1x9gknd 10537 14 vein vein NN cord-010119-t1x9gknd 10537 15 for for IN cord-010119-t1x9gknd 10537 16 this this DT cord-010119-t1x9gknd 10537 17 procedure procedure NN cord-010119-t1x9gknd 10537 18 can can MD cord-010119-t1x9gknd 10537 19 be be VB cord-010119-t1x9gknd 10537 20 a a DT cord-010119-t1x9gknd 10537 21 challenge challenge NN cord-010119-t1x9gknd 10537 22 . . . cord-010119-t1x9gknd 10538 1 Unacceptable unacceptable JJ cord-010119-t1x9gknd 10538 2 vein vein NN cord-010119-t1x9gknd 10538 3 selection selection NN cord-010119-t1x9gknd 10538 4 or or CC cord-010119-t1x9gknd 10538 5 incorrect incorrect JJ cord-010119-t1x9gknd 10538 6 needle needle NN cord-010119-t1x9gknd 10538 7 placement placement NN cord-010119-t1x9gknd 10538 8 can can MD cord-010119-t1x9gknd 10538 9 lead lead VB cord-010119-t1x9gknd 10538 10 to to IN cord-010119-t1x9gknd 10538 11 incomplete incomplete JJ cord-010119-t1x9gknd 10538 12 collection collection NN cord-010119-t1x9gknd 10538 13 or or CC cord-010119-t1x9gknd 10538 14 infiltration infiltration NN cord-010119-t1x9gknd 10538 15 . . . cord-010119-t1x9gknd 10539 1 In in IN cord-010119-t1x9gknd 10539 2 a a DT cord-010119-t1x9gknd 10539 3 blood blood NN cord-010119-t1x9gknd 10539 4 donor donor NN cord-010119-t1x9gknd 10539 5 center center NN cord-010119-t1x9gknd 10539 6 , , , cord-010119-t1x9gknd 10539 7 the the DT cord-010119-t1x9gknd 10539 8 primary primary JJ cord-010119-t1x9gknd 10539 9 selection selection NN cord-010119-t1x9gknd 10539 10 of of IN cord-010119-t1x9gknd 10539 11 a a DT cord-010119-t1x9gknd 10539 12 vein vein NN cord-010119-t1x9gknd 10539 13 is be VBZ cord-010119-t1x9gknd 10539 14 done do VBN cord-010119-t1x9gknd 10539 15 by by IN cord-010119-t1x9gknd 10539 16 palpation palpation NN cord-010119-t1x9gknd 10539 17 within within IN cord-010119-t1x9gknd 10539 18 the the DT cord-010119-t1x9gknd 10539 19 antecubital antecubital JJ cord-010119-t1x9gknd 10539 20 area area NN cord-010119-t1x9gknd 10539 21 . . . cord-010119-t1x9gknd 10540 1 Prior prior RB cord-010119-t1x9gknd 10540 2 to to IN cord-010119-t1x9gknd 10540 3 needle needle NN cord-010119-t1x9gknd 10540 4 insertion insertion NN cord-010119-t1x9gknd 10540 5 , , , cord-010119-t1x9gknd 10540 6 the the DT cord-010119-t1x9gknd 10540 7 skin skin NN cord-010119-t1x9gknd 10540 8 at at IN cord-010119-t1x9gknd 10540 9 the the DT cord-010119-t1x9gknd 10540 10 site site NN cord-010119-t1x9gknd 10540 11 must must MD cord-010119-t1x9gknd 10540 12 be be VB cord-010119-t1x9gknd 10540 13 prepared prepared JJ cord-010119-t1x9gknd 10540 14 and and CC cord-010119-t1x9gknd 10540 15 contact contact NN cord-010119-t1x9gknd 10540 16 avoided avoid VBN cord-010119-t1x9gknd 10540 17 until until IN cord-010119-t1x9gknd 10540 18 after after IN cord-010119-t1x9gknd 10540 19 needle needle NN cord-010119-t1x9gknd 10540 20 is be VBZ cord-010119-t1x9gknd 10540 21 placed place VBN cord-010119-t1x9gknd 10540 22 . . . cord-010119-t1x9gknd 10541 1 Vein vein NN cord-010119-t1x9gknd 10541 2 illuminator illuminator NN cord-010119-t1x9gknd 10541 3 ( ( -LRB- cord-010119-t1x9gknd 10541 4 VI VI NNP cord-010119-t1x9gknd 10541 5 ) ) -RRB- cord-010119-t1x9gknd 10541 6 devices device NNS cord-010119-t1x9gknd 10541 7 are be VBP cord-010119-t1x9gknd 10541 8 available available JJ cord-010119-t1x9gknd 10541 9 to to TO cord-010119-t1x9gknd 10541 10 aid aid VB cord-010119-t1x9gknd 10541 11 in in IN cord-010119-t1x9gknd 10541 12 visual visual JJ cord-010119-t1x9gknd 10541 13 display display NN cord-010119-t1x9gknd 10541 14 of of IN cord-010119-t1x9gknd 10541 15 potentially potentially RB cord-010119-t1x9gknd 10541 16 suitable suitable JJ cord-010119-t1x9gknd 10541 17 veins vein NNS cord-010119-t1x9gknd 10541 18 . . . cord-010119-t1x9gknd 10542 1 Such such JJ cord-010119-t1x9gknd 10542 2 a a DT cord-010119-t1x9gknd 10542 3 device device NN cord-010119-t1x9gknd 10542 4 was be VBD cord-010119-t1x9gknd 10542 5 made make VBN cord-010119-t1x9gknd 10542 6 available available JJ cord-010119-t1x9gknd 10542 7 to to IN cord-010119-t1x9gknd 10542 8 staff staff NN cord-010119-t1x9gknd 10542 9 in in IN cord-010119-t1x9gknd 10542 10 March March NNP cord-010119-t1x9gknd 10542 11 of of IN cord-010119-t1x9gknd 10542 12 2010 2010 CD cord-010119-t1x9gknd 10542 13 . . . cord-010119-t1x9gknd 10543 1 After after IN cord-010119-t1x9gknd 10543 2 an an DT cord-010119-t1x9gknd 10543 3 initial initial JJ cord-010119-t1x9gknd 10543 4 testing testing NN cord-010119-t1x9gknd 10543 5 and and CC cord-010119-t1x9gknd 10543 6 instructional instructional JJ cord-010119-t1x9gknd 10543 7 period period NN cord-010119-t1x9gknd 10543 8 , , , cord-010119-t1x9gknd 10543 9 the the DT cord-010119-t1x9gknd 10543 10 VI VI NNP cord-010119-t1x9gknd 10543 11 has have VBZ cord-010119-t1x9gknd 10543 12 since since IN cord-010119-t1x9gknd 10543 13 not not RB cord-010119-t1x9gknd 10543 14 been be VBN cord-010119-t1x9gknd 10543 15 used use VBN cord-010119-t1x9gknd 10543 16 by by IN cord-010119-t1x9gknd 10543 17 staff staff NN cord-010119-t1x9gknd 10543 18 . . . cord-010119-t1x9gknd 10544 1 The the DT cord-010119-t1x9gknd 10544 2 objective objective NN cord-010119-t1x9gknd 10544 3 of of IN cord-010119-t1x9gknd 10544 4 this this DT cord-010119-t1x9gknd 10544 5 study study NN cord-010119-t1x9gknd 10544 6 is be VBZ cord-010119-t1x9gknd 10544 7 to to TO cord-010119-t1x9gknd 10544 8 discover discover VB cord-010119-t1x9gknd 10544 9 reasons reason NNS cord-010119-t1x9gknd 10544 10 why why WRB cord-010119-t1x9gknd 10544 11 staff staff NN cord-010119-t1x9gknd 10544 12 does do VBZ cord-010119-t1x9gknd 10544 13 not not RB cord-010119-t1x9gknd 10544 14 use use VB cord-010119-t1x9gknd 10544 15 the the DT cord-010119-t1x9gknd 10544 16 VI VI NNP cord-010119-t1x9gknd 10544 17 to to TO cord-010119-t1x9gknd 10544 18 identify identify VB cord-010119-t1x9gknd 10544 19 potentially potentially RB cord-010119-t1x9gknd 10544 20 suitable suitable JJ cord-010119-t1x9gknd 10544 21 veins vein NNS cord-010119-t1x9gknd 10544 22 . . . cord-010119-t1x9gknd 10545 1 Study Study NNP cord-010119-t1x9gknd 10545 2 Design Design NNP cord-010119-t1x9gknd 10545 3 / / SYM cord-010119-t1x9gknd 10545 4 Method method NN cord-010119-t1x9gknd 10545 5 : : : cord-010119-t1x9gknd 10546 1 A a DT cord-010119-t1x9gknd 10546 2 staff staff NN cord-010119-t1x9gknd 10546 3 survey survey NN cord-010119-t1x9gknd 10546 4 was be VBD cord-010119-t1x9gknd 10546 5 developed develop VBN cord-010119-t1x9gknd 10546 6 and and CC cord-010119-t1x9gknd 10546 7 distributed distribute VBN cord-010119-t1x9gknd 10546 8 to to IN cord-010119-t1x9gknd 10546 9 staff staff NN cord-010119-t1x9gknd 10546 10 in in IN cord-010119-t1x9gknd 10546 11 March March NNP cord-010119-t1x9gknd 10546 12 2017 2017 CD cord-010119-t1x9gknd 10546 13 to to TO cord-010119-t1x9gknd 10546 14 inquire inquire VB cord-010119-t1x9gknd 10546 15 about about IN cord-010119-t1x9gknd 10546 16 usage usage NN cord-010119-t1x9gknd 10546 17 of of IN cord-010119-t1x9gknd 10546 18 the the DT cord-010119-t1x9gknd 10546 19 VI vi NN cord-010119-t1x9gknd 10546 20 and and CC cord-010119-t1x9gknd 10546 21 obtain obtain VB cord-010119-t1x9gknd 10546 22 feedback feedback NN cord-010119-t1x9gknd 10546 23 about about IN cord-010119-t1x9gknd 10546 24 the the DT cord-010119-t1x9gknd 10546 25 device device NN cord-010119-t1x9gknd 10546 26 . . . cord-010119-t1x9gknd 10547 1 At at IN cord-010119-t1x9gknd 10547 2 the the DT cord-010119-t1x9gknd 10547 3 time time NN cord-010119-t1x9gknd 10547 4 that that WDT cord-010119-t1x9gknd 10547 5 the the DT cord-010119-t1x9gknd 10547 6 survey survey NN cord-010119-t1x9gknd 10547 7 was be VBD cord-010119-t1x9gknd 10547 8 sent send VBN cord-010119-t1x9gknd 10547 9 , , , cord-010119-t1x9gknd 10547 10 the the DT cord-010119-t1x9gknd 10547 11 device device NN cord-010119-t1x9gknd 10547 12 had have VBD cord-010119-t1x9gknd 10547 13 been be VBN cord-010119-t1x9gknd 10547 14 available available JJ cord-010119-t1x9gknd 10547 15 for for IN cord-010119-t1x9gknd 10547 16 several several JJ cord-010119-t1x9gknd 10547 17 years year NNS cord-010119-t1x9gknd 10547 18 . . . cord-010119-t1x9gknd 10548 1 The the DT cord-010119-t1x9gknd 10548 2 survey survey NN cord-010119-t1x9gknd 10548 3 included include VBD cord-010119-t1x9gknd 10548 4 questions question NNS cord-010119-t1x9gknd 10548 5 involving involve VBG cord-010119-t1x9gknd 10548 6 frequency frequency NN cord-010119-t1x9gknd 10548 7 of of IN cord-010119-t1x9gknd 10548 8 use use NN cord-010119-t1x9gknd 10548 9 , , , cord-010119-t1x9gknd 10548 10 adequacy adequacy NN cord-010119-t1x9gknd 10548 11 of of IN cord-010119-t1x9gknd 10548 12 training training NN cord-010119-t1x9gknd 10548 13 , , , cord-010119-t1x9gknd 10548 14 comfort comfort NN cord-010119-t1x9gknd 10548 15 with with IN cord-010119-t1x9gknd 10548 16 using use VBG cord-010119-t1x9gknd 10548 17 the the DT cord-010119-t1x9gknd 10548 18 device device NN cord-010119-t1x9gknd 10548 19 , , , cord-010119-t1x9gknd 10548 20 knowledge knowledge NN cord-010119-t1x9gknd 10548 21 of of IN cord-010119-t1x9gknd 10548 22 the the DT cord-010119-t1x9gknd 10548 23 device device NN cord-010119-t1x9gknd 10548 24 's 's POS cord-010119-t1x9gknd 10548 25 storage storage NN cord-010119-t1x9gknd 10548 26 location location NN cord-010119-t1x9gknd 10548 27 , , , cord-010119-t1x9gknd 10548 28 willingness willingness NN cord-010119-t1x9gknd 10548 29 try try VB cord-010119-t1x9gknd 10548 30 the the DT cord-010119-t1x9gknd 10548 31 device device NN cord-010119-t1x9gknd 10548 32 , , , cord-010119-t1x9gknd 10548 33 and and CC cord-010119-t1x9gknd 10548 34 general general JJ cord-010119-t1x9gknd 10548 35 feedback feedback NN cord-010119-t1x9gknd 10548 36 . . . cord-010119-t1x9gknd 10549 1 Results/ Results/ . cord-010119-t1x9gknd 10550 1 Finding finding NN cord-010119-t1x9gknd 10550 2 : : : cord-010119-t1x9gknd 10551 1 The the DT cord-010119-t1x9gknd 10551 2 survey survey NN cord-010119-t1x9gknd 10551 3 had have VBD cord-010119-t1x9gknd 10551 4 a a DT cord-010119-t1x9gknd 10551 5 77 77 CD cord-010119-t1x9gknd 10551 6 % % NN cord-010119-t1x9gknd 10551 7 response response NN cord-010119-t1x9gknd 10551 8 rate rate NN cord-010119-t1x9gknd 10551 9 ( ( -LRB- cord-010119-t1x9gknd 10551 10 n533 n533 NNP cord-010119-t1x9gknd 10551 11 ) ) -RRB- cord-010119-t1x9gknd 10551 12 . . . cord-010119-t1x9gknd 10552 1 Of of IN cord-010119-t1x9gknd 10552 2 these these DT cord-010119-t1x9gknd 10552 3 , , , cord-010119-t1x9gknd 10552 4 78.8 78.8 CD cord-010119-t1x9gknd 10552 5 % % NN cord-010119-t1x9gknd 10552 6 have have VBP cord-010119-t1x9gknd 10552 7 never never RB cord-010119-t1x9gknd 10552 8 or or CC cord-010119-t1x9gknd 10552 9 very very RB cord-010119-t1x9gknd 10552 10 rarely rarely RB cord-010119-t1x9gknd 10552 11 utilized utilize VBN cord-010119-t1x9gknd 10552 12 the the DT cord-010119-t1x9gknd 10552 13 VI VI NNP cord-010119-t1x9gknd 10552 14 . . . cord-010119-t1x9gknd 10553 1 Self self NN cord-010119-t1x9gknd 10553 2 - - HYPH cord-010119-t1x9gknd 10553 3 reported report VBN cord-010119-t1x9gknd 10553 4 reasons reason NNS cord-010119-t1x9gknd 10553 5 for for IN cord-010119-t1x9gknd 10553 6 low low JJ cord-010119-t1x9gknd 10553 7 utilization utilization NN cord-010119-t1x9gknd 10553 8 focused focus VBN cord-010119-t1x9gknd 10553 9 on on IN cord-010119-t1x9gknd 10553 10 two two CD cord-010119-t1x9gknd 10553 11 dominant dominant JJ cord-010119-t1x9gknd 10553 12 themes theme NNS cord-010119-t1x9gknd 10553 13 . . . cord-010119-t1x9gknd 10554 1 First first RB cord-010119-t1x9gknd 10554 2 , , , cord-010119-t1x9gknd 10554 3 that that IN cord-010119-t1x9gknd 10554 4 the the DT cord-010119-t1x9gknd 10554 5 device device NN cord-010119-t1x9gknd 10554 6 is be VBZ cord-010119-t1x9gknd 10554 7 not not RB cord-010119-t1x9gknd 10554 8 needed need VBN cord-010119-t1x9gknd 10554 9 and and CC cord-010119-t1x9gknd 10554 10 second second RB cord-010119-t1x9gknd 10554 11 that that IN cord-010119-t1x9gknd 10554 12 it -PRON- PRP cord-010119-t1x9gknd 10554 13 does do VBZ cord-010119-t1x9gknd 10554 14 n't not RB cord-010119-t1x9gknd 10554 15 accurately accurately RB cord-010119-t1x9gknd 10554 16 show show VB cord-010119-t1x9gknd 10554 17 veins vein NNS cord-010119-t1x9gknd 10554 18 . . . cord-010119-t1x9gknd 10555 1 87.9 87.9 CD cord-010119-t1x9gknd 10555 2 % % NN cord-010119-t1x9gknd 10555 3 of of IN cord-010119-t1x9gknd 10555 4 respondents respondent NNS cord-010119-t1x9gknd 10555 5 are be VBP cord-010119-t1x9gknd 10555 6 aware aware JJ cord-010119-t1x9gknd 10555 7 of of IN cord-010119-t1x9gknd 10555 8 where where WRB cord-010119-t1x9gknd 10555 9 the the DT cord-010119-t1x9gknd 10555 10 VI VI NNP cord-010119-t1x9gknd 10555 11 is be VBZ cord-010119-t1x9gknd 10555 12 stored store VBN cord-010119-t1x9gknd 10555 13 and and CC cord-010119-t1x9gknd 10555 14 a a DT cord-010119-t1x9gknd 10555 15 more more RBR cord-010119-t1x9gknd 10555 16 accessible accessible JJ cord-010119-t1x9gknd 10555 17 location location NN cord-010119-t1x9gknd 10555 18 to to TO cord-010119-t1x9gknd 10555 19 share share VB cord-010119-t1x9gknd 10555 20 the the DT cord-010119-t1x9gknd 10555 21 device device NN cord-010119-t1x9gknd 10555 22 was be VBD cord-010119-t1x9gknd 10555 23 not not RB cord-010119-t1x9gknd 10555 24 identified identify VBN cord-010119-t1x9gknd 10555 25 . . . cord-010119-t1x9gknd 10556 1 Although although IN cord-010119-t1x9gknd 10556 2 93.9 93.9 CD cord-010119-t1x9gknd 10556 3 % % NN cord-010119-t1x9gknd 10556 4 of of IN cord-010119-t1x9gknd 10556 5 respondents respondent NNS cord-010119-t1x9gknd 10556 6 have have VBP cord-010119-t1x9gknd 10556 7 been be VBN cord-010119-t1x9gknd 10556 8 provided provide VBN cord-010119-t1x9gknd 10556 9 training training NN cord-010119-t1x9gknd 10556 10 on on IN cord-010119-t1x9gknd 10556 11 using use VBG cord-010119-t1x9gknd 10556 12 the the DT cord-010119-t1x9gknd 10556 13 VI VI NNP cord-010119-t1x9gknd 10556 14 , , , cord-010119-t1x9gknd 10556 15 the the DT cord-010119-t1x9gknd 10556 16 group group NN cord-010119-t1x9gknd 10556 17 was be VBD cord-010119-t1x9gknd 10556 18 mixed mix VBN cord-010119-t1x9gknd 10556 19 regarding regard VBG cord-010119-t1x9gknd 10556 20 their -PRON- PRP$ cord-010119-t1x9gknd 10556 21 comfort comfort NN cord-010119-t1x9gknd 10556 22 level level NN cord-010119-t1x9gknd 10556 23 in in IN cord-010119-t1x9gknd 10556 24 using use VBG cord-010119-t1x9gknd 10556 25 the the DT cord-010119-t1x9gknd 10556 26 device device NN cord-010119-t1x9gknd 10556 27 independently independently RB cord-010119-t1x9gknd 10556 28 . . . cord-010119-t1x9gknd 10557 1 Only only RB cord-010119-t1x9gknd 10557 2 48 48 CD cord-010119-t1x9gknd 10557 3 % % NN cord-010119-t1x9gknd 10557 4 of of IN cord-010119-t1x9gknd 10557 5 the the DT cord-010119-t1x9gknd 10557 6 group group NN cord-010119-t1x9gknd 10557 7 was be VBD cord-010119-t1x9gknd 10557 8 willing willing JJ cord-010119-t1x9gknd 10557 9 to to TO cord-010119-t1x9gknd 10557 10 try try VB cord-010119-t1x9gknd 10557 11 VI VI NNP cord-010119-t1x9gknd 10557 12 . . . cord-010119-t1x9gknd 10558 1 Conclusion conclusion NN cord-010119-t1x9gknd 10558 2 : : : cord-010119-t1x9gknd 10559 1 Infiltration infiltration NN cord-010119-t1x9gknd 10559 2 and and CC cord-010119-t1x9gknd 10559 3 incomplete incomplete JJ cord-010119-t1x9gknd 10559 4 collection collection NN cord-010119-t1x9gknd 10559 5 account account NN cord-010119-t1x9gknd 10559 6 for for IN cord-010119-t1x9gknd 10559 7 approximate approximate JJ cord-010119-t1x9gknd 10559 8 3 3 CD cord-010119-t1x9gknd 10559 9 % % NN cord-010119-t1x9gknd 10559 10 ( ( -LRB- cord-010119-t1x9gknd 10559 11 770 770 CD cord-010119-t1x9gknd 10559 12 units unit NNS cord-010119-t1x9gknd 10559 13 / / SYM cord-010119-t1x9gknd 10559 14 year year NN cord-010119-t1x9gknd 10559 15 ) ) -RRB- cord-010119-t1x9gknd 10559 16 of of IN cord-010119-t1x9gknd 10559 17 qualified qualified JJ cord-010119-t1x9gknd 10559 18 blood blood NN cord-010119-t1x9gknd 10559 19 donors donor NNS cord-010119-t1x9gknd 10559 20 , , , cord-010119-t1x9gknd 10559 21 yet yet RB cord-010119-t1x9gknd 10560 1 VI VI NNP cord-010119-t1x9gknd 10560 2 does do VBZ cord-010119-t1x9gknd 10560 3 not not RB cord-010119-t1x9gknd 10560 4 appear appear VB cord-010119-t1x9gknd 10560 5 to to TO cord-010119-t1x9gknd 10560 6 be be VB cord-010119-t1x9gknd 10560 7 a a DT cord-010119-t1x9gknd 10560 8 viable viable JJ cord-010119-t1x9gknd 10560 9 solution solution NN cord-010119-t1x9gknd 10560 10 for for IN cord-010119-t1x9gknd 10560 11 our -PRON- PRP$ cord-010119-t1x9gknd 10560 12 blood blood NN cord-010119-t1x9gknd 10560 13 donor donor NN cord-010119-t1x9gknd 10560 14 program program NN cord-010119-t1x9gknd 10560 15 . . . cord-010119-t1x9gknd 10561 1 There there EX cord-010119-t1x9gknd 10561 2 seems seem VBZ cord-010119-t1x9gknd 10561 3 to to TO cord-010119-t1x9gknd 10561 4 be be VB cord-010119-t1x9gknd 10561 5 both both CC cord-010119-t1x9gknd 10561 6 an an DT cord-010119-t1x9gknd 10561 7 opportunity opportunity NN cord-010119-t1x9gknd 10561 8 and and CC cord-010119-t1x9gknd 10561 9 challenge challenge NN cord-010119-t1x9gknd 10561 10 with with IN cord-010119-t1x9gknd 10561 11 VI VI NNP cord-010119-t1x9gknd 10561 12 implementation implementation NN cord-010119-t1x9gknd 10561 13 . . . cord-010119-t1x9gknd 10562 1 The the DT cord-010119-t1x9gknd 10562 2 opportunity opportunity NN cord-010119-t1x9gknd 10562 3 is be VBZ cord-010119-t1x9gknd 10562 4 to to TO cord-010119-t1x9gknd 10562 5 create create VB cord-010119-t1x9gknd 10562 6 critical critical JJ cord-010119-t1x9gknd 10562 7 awareness awareness NN cord-010119-t1x9gknd 10562 8 of of IN cord-010119-t1x9gknd 10562 9 problems problem NNS cord-010119-t1x9gknd 10562 10 with with IN cord-010119-t1x9gknd 10562 11 vein vein NN cord-010119-t1x9gknd 10562 12 cannulation cannulation NN cord-010119-t1x9gknd 10562 13 . . . cord-010119-t1x9gknd 10563 1 The the DT cord-010119-t1x9gknd 10563 2 challenge challenge NN cord-010119-t1x9gknd 10563 3 is be VBZ cord-010119-t1x9gknd 10563 4 to to TO cord-010119-t1x9gknd 10563 5 identify identify VB cord-010119-t1x9gknd 10563 6 a a DT cord-010119-t1x9gknd 10563 7 device device NN cord-010119-t1x9gknd 10563 8 that that WDT cord-010119-t1x9gknd 10563 9 is be VBZ cord-010119-t1x9gknd 10563 10 more more RBR cord-010119-t1x9gknd 10563 11 effective effective JJ cord-010119-t1x9gknd 10563 12 at at IN cord-010119-t1x9gknd 10563 13 visualizing visualize VBG cord-010119-t1x9gknd 10563 14 deeper deep JJR cord-010119-t1x9gknd 10563 15 veins vein NNS cord-010119-t1x9gknd 10563 16 necessary necessary JJ cord-010119-t1x9gknd 10563 17 for for IN cord-010119-t1x9gknd 10563 18 blood blood NN cord-010119-t1x9gknd 10563 19 donation donation NN cord-010119-t1x9gknd 10563 20 . . . cord-010119-t1x9gknd 10564 1 Benefits benefit NNS cord-010119-t1x9gknd 10564 2 of of IN cord-010119-t1x9gknd 10564 3 Converting convert VBG cord-010119-t1x9gknd 10564 4 From from IN cord-010119-t1x9gknd 10564 5 MCS1 MCS1 NNP cord-010119-t1x9gknd 10565 1 To to IN cord-010119-t1x9gknd 10565 2 Alyx Alyx NNP cord-010119-t1x9gknd 10565 3 Penny Penny NNP cord-010119-t1x9gknd 10565 4 Schroeder Schroeder NNP cord-010119-t1x9gknd 10565 5 * * NFP cord-010119-t1x9gknd 10565 6 and and CC cord-010119-t1x9gknd 10565 7 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 10565 8 Parker Parker NNP cord-010119-t1x9gknd 10565 9 . . . cord-010119-t1x9gknd 10566 1 Indiana Indiana NNP cord-010119-t1x9gknd 10566 2 Blood Blood NNP cord-010119-t1x9gknd 10566 3 Center Center NNP cord-010119-t1x9gknd 10566 4 Background Background NNP cord-010119-t1x9gknd 10566 5 / / SYM cord-010119-t1x9gknd 10566 6 Case Case NNP cord-010119-t1x9gknd 10566 7 Studies Studies NNPS cord-010119-t1x9gknd 10566 8 : : : cord-010119-t1x9gknd 10567 1 In in IN cord-010119-t1x9gknd 10567 2 2015 2015 CD cord-010119-t1x9gknd 10567 3 , , , cord-010119-t1x9gknd 10567 4 apheresis apheresis NN cord-010119-t1x9gknd 10567 5 red red JJ cord-010119-t1x9gknd 10567 6 cells cell NNS cord-010119-t1x9gknd 10567 7 ( ( -LRB- cord-010119-t1x9gknd 10567 8 aRC aRC NNP cord-010119-t1x9gknd 10567 9 ) ) -RRB- cord-010119-t1x9gknd 10567 10 represented represent VBD cord-010119-t1x9gknd 10567 11 4.7 4.7 CD cord-010119-t1x9gknd 10567 12 % % NN cord-010119-t1x9gknd 10567 13 of of IN cord-010119-t1x9gknd 10567 14 total total JJ cord-010119-t1x9gknd 10567 15 red red JJ cord-010119-t1x9gknd 10567 16 cell cell NN cord-010119-t1x9gknd 10567 17 collections collection NNS cord-010119-t1x9gknd 10567 18 at at IN cord-010119-t1x9gknd 10567 19 our -PRON- PRP$ cord-010119-t1x9gknd 10567 20 center center NN cord-010119-t1x9gknd 10567 21 . . . cord-010119-t1x9gknd 10568 1 HAE HAE NNP cord-010119-t1x9gknd 10568 2 MCS1 MCS1 NNP cord-010119-t1x9gknd 10568 3 LN8150 ln8150 NN cord-010119-t1x9gknd 10568 4 was be VBD cord-010119-t1x9gknd 10568 5 utilized utilize VBN cord-010119-t1x9gknd 10568 6 to to TO cord-010119-t1x9gknd 10568 7 collect collect VB cord-010119-t1x9gknd 10568 8 aRC aRC NNP cord-010119-t1x9gknd 10568 9 . . . cord-010119-t1x9gknd 10569 1 Due due IN cord-010119-t1x9gknd 10569 2 to to IN cord-010119-t1x9gknd 10569 3 the the DT cord-010119-t1x9gknd 10569 4 age age NN cord-010119-t1x9gknd 10569 5 of of IN cord-010119-t1x9gknd 10569 6 the the DT cord-010119-t1x9gknd 10569 7 instruments instrument NNS cord-010119-t1x9gknd 10569 8 , , , cord-010119-t1x9gknd 10569 9 challenges challenge NNS cord-010119-t1x9gknd 10569 10 with with IN cord-010119-t1x9gknd 10569 11 collections collection NNS cord-010119-t1x9gknd 10569 12 on on IN cord-010119-t1x9gknd 10569 13 mobiles mobile NNS cord-010119-t1x9gknd 10569 14 as as RB cord-010119-t1x9gknd 10569 15 well well RB cord-010119-t1x9gknd 10569 16 as as IN cord-010119-t1x9gknd 10569 17 the the DT cord-010119-t1x9gknd 10569 18 need need NN cord-010119-t1x9gknd 10569 19 to to TO cord-010119-t1x9gknd 10569 20 increase increase VB cord-010119-t1x9gknd 10569 21 collection collection NN cord-010119-t1x9gknd 10569 22 of of IN cord-010119-t1x9gknd 10569 23 right right JJ cord-010119-t1x9gknd 10569 24 type type NN cord-010119-t1x9gknd 10569 25 products product NNS cord-010119-t1x9gknd 10569 26 , , , cord-010119-t1x9gknd 10569 27 the the DT cord-010119-t1x9gknd 10569 28 decision decision NN cord-010119-t1x9gknd 10569 29 was be VBD cord-010119-t1x9gknd 10569 30 made make VBN cord-010119-t1x9gknd 10569 31 to to TO cord-010119-t1x9gknd 10569 32 change change VB cord-010119-t1x9gknd 10569 33 technologies technology NNS cord-010119-t1x9gknd 10569 34 . . . cord-010119-t1x9gknd 10570 1 Study Study NNP cord-010119-t1x9gknd 10570 2 Design Design NNP cord-010119-t1x9gknd 10570 3 / / SYM cord-010119-t1x9gknd 10570 4 Method method NN cord-010119-t1x9gknd 10570 5 : : : cord-010119-t1x9gknd 10571 1 Fresenius Fresenius NNP cord-010119-t1x9gknd 10571 2 Kabi Kabi NNP cord-010119-t1x9gknd 10571 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 10571 4 the the DT cord-010119-t1x9gknd 10571 5 Fenwal Fenwal NNP cord-010119-t1x9gknd 10571 6 Alyx Alyx NNP cord-010119-t1x9gknd 10571 7 technology technology NN cord-010119-t1x9gknd 10571 8 as as RB cord-010119-t1x9gknd 10571 9 well well RB cord-010119-t1x9gknd 10571 10 as as IN cord-010119-t1x9gknd 10571 11 the the DT cord-010119-t1x9gknd 10571 12 business business NN cord-010119-t1x9gknd 10571 13 case case NN cord-010119-t1x9gknd 10571 14 to to IN cord-010119-t1x9gknd 10571 15 the the DT cord-010119-t1x9gknd 10571 16 primary primary JJ cord-010119-t1x9gknd 10571 17 stakeholders stakeholder NNS cord-010119-t1x9gknd 10571 18 . . . cord-010119-t1x9gknd 10572 1 All all DT cord-010119-t1x9gknd 10572 2 implicated implicate VBN cord-010119-t1x9gknd 10572 3 departments department NNS cord-010119-t1x9gknd 10572 4 were be VBD cord-010119-t1x9gknd 10572 5 involved involve VBN cord-010119-t1x9gknd 10572 6 in in IN cord-010119-t1x9gknd 10572 7 the the DT cord-010119-t1x9gknd 10572 8 initial initial JJ cord-010119-t1x9gknd 10572 9 impact impact NN cord-010119-t1x9gknd 10572 10 assessment assessment NN cord-010119-t1x9gknd 10572 11 . . . cord-010119-t1x9gknd 10573 1 A a DT cord-010119-t1x9gknd 10573 2 multidepartment multidepartment NN cord-010119-t1x9gknd 10573 3 kick kick NN cord-010119-t1x9gknd 10573 4 off off RP cord-010119-t1x9gknd 10573 5 meeting meeting NN cord-010119-t1x9gknd 10573 6 was be VBD cord-010119-t1x9gknd 10573 7 held hold VBN cord-010119-t1x9gknd 10573 8 and and CC cord-010119-t1x9gknd 10573 9 project project NN cord-010119-t1x9gknd 10573 10 team team NN cord-010119-t1x9gknd 10573 11 formed form VBD cord-010119-t1x9gknd 10573 12 . . . cord-010119-t1x9gknd 10574 1 Due due IN cord-010119-t1x9gknd 10574 2 to to IN cord-010119-t1x9gknd 10574 3 product product NN cord-010119-t1x9gknd 10574 4 demands demand NNS cord-010119-t1x9gknd 10574 5 , , , cord-010119-t1x9gknd 10574 6 the the DT cord-010119-t1x9gknd 10574 7 decision decision NN cord-010119-t1x9gknd 10574 8 was be VBD cord-010119-t1x9gknd 10574 9 made make VBN cord-010119-t1x9gknd 10574 10 to to TO cord-010119-t1x9gknd 10574 11 validate validate VB cord-010119-t1x9gknd 10574 12 aRC aRC '' cord-010119-t1x9gknd 10574 13 and and CC cord-010119-t1x9gknd 10574 14 plasma plasma NN cord-010119-t1x9gknd 10574 15 apheresis apheresis NN cord-010119-t1x9gknd 10574 16 . . . cord-010119-t1x9gknd 10575 1 The the DT cord-010119-t1x9gknd 10575 2 primary primary JJ cord-010119-t1x9gknd 10575 3 departments department NNS cord-010119-t1x9gknd 10575 4 affected affect VBD cord-010119-t1x9gknd 10575 5 were be VBD cord-010119-t1x9gknd 10575 6 Blood blood NN cord-010119-t1x9gknd 10575 7 Collection Collection NNP cord-010119-t1x9gknd 10575 8 and and CC cord-010119-t1x9gknd 10575 9 Production Production NNP cord-010119-t1x9gknd 10575 10 . . . cord-010119-t1x9gknd 10576 1 Fresenius Fresenius NNP cord-010119-t1x9gknd 10576 2 Kabi Kabi NNP cord-010119-t1x9gknd 10576 3 provided provide VBD cord-010119-t1x9gknd 10576 4 sample sample NN cord-010119-t1x9gknd 10576 5 validation validation NN cord-010119-t1x9gknd 10576 6 plans plan NNS cord-010119-t1x9gknd 10576 7 , , , cord-010119-t1x9gknd 10576 8 SOPs sop NNS cord-010119-t1x9gknd 10576 9 , , , cord-010119-t1x9gknd 10576 10 training training NN cord-010119-t1x9gknd 10576 11 and and CC cord-010119-t1x9gknd 10576 12 training training NN cord-010119-t1x9gknd 10576 13 materials material NNS cord-010119-t1x9gknd 10576 14 for for IN cord-010119-t1x9gknd 10576 15 use use NN cord-010119-t1x9gknd 10576 16 . . . cord-010119-t1x9gknd 10577 1 Four four CD cord-010119-t1x9gknd 10577 2 mobile mobile NN cord-010119-t1x9gknd 10577 3 - - HYPH cord-010119-t1x9gknd 10577 4 carts cart NNS cord-010119-t1x9gknd 10577 5 were be VBD cord-010119-t1x9gknd 10577 6 purchased purchase VBN cord-010119-t1x9gknd 10577 7 for for IN cord-010119-t1x9gknd 10577 8 easy easy JJ cord-010119-t1x9gknd 10577 9 transportation transportation NN cord-010119-t1x9gknd 10577 10 of of IN cord-010119-t1x9gknd 10577 11 Alyx Alyx NNP cord-010119-t1x9gknd 10577 12 and and CC cord-010119-t1x9gknd 10577 13 quick quick JJ cord-010119-t1x9gknd 10577 14 - - HYPH cord-010119-t1x9gknd 10577 15 connect connect JJ cord-010119-t1x9gknd 10577 16 feet foot NNS cord-010119-t1x9gknd 10577 17 for for IN cord-010119-t1x9gknd 10577 18 installation installation NN cord-010119-t1x9gknd 10577 19 on on IN cord-010119-t1x9gknd 10577 20 mobile mobile JJ cord-010119-t1x9gknd 10577 21 buses bus NNS cord-010119-t1x9gknd 10577 22 . . . cord-010119-t1x9gknd 10578 1 The the DT cord-010119-t1x9gknd 10578 2 Lead Lead NNP cord-010119-t1x9gknd 10578 3 Trainer trainer NN cord-010119-t1x9gknd 10578 4 and and CC cord-010119-t1x9gknd 10578 5 the the DT cord-010119-t1x9gknd 10578 6 BC BC NNP cord-010119-t1x9gknd 10578 7 Technical Technical NNP cord-010119-t1x9gknd 10578 8 Administrator Administrator NNP cord-010119-t1x9gknd 10578 9 traveled travel VBD cord-010119-t1x9gknd 10578 10 to to IN cord-010119-t1x9gknd 10578 11 an an DT cord-010119-t1x9gknd 10578 12 affiliate affiliate NN cord-010119-t1x9gknd 10578 13 blood blood NN cord-010119-t1x9gknd 10578 14 center center NN cord-010119-t1x9gknd 10578 15 to to TO cord-010119-t1x9gknd 10578 16 observe observe VB cord-010119-t1x9gknd 10578 17 their -PRON- PRP$ cord-010119-t1x9gknd 10578 18 Alyx Alyx NNP cord-010119-t1x9gknd 10578 19 program program NN cord-010119-t1x9gknd 10578 20 and and CC cord-010119-t1x9gknd 10578 21 identify identify VB cord-010119-t1x9gknd 10578 22 best good JJS cord-010119-t1x9gknd 10578 23 practices practice NNS cord-010119-t1x9gknd 10578 24 . . . cord-010119-t1x9gknd 10579 1 A a DT cord-010119-t1x9gknd 10579 2 team team NN cord-010119-t1x9gknd 10579 3 of of IN cord-010119-t1x9gknd 10579 4 Blood Blood NNP cord-010119-t1x9gknd 10579 5 Collection Collection NNP cord-010119-t1x9gknd 10579 6 trainers trainer NNS cord-010119-t1x9gknd 10579 7 and and CC cord-010119-t1x9gknd 10579 8 preceptors preceptor NNS cord-010119-t1x9gknd 10579 9 were be VBD cord-010119-t1x9gknd 10579 10 the the DT cord-010119-t1x9gknd 10579 11 initial initial JJ cord-010119-t1x9gknd 10579 12 group group NN cord-010119-t1x9gknd 10579 13 trained train VBN cord-010119-t1x9gknd 10579 14 and and CC cord-010119-t1x9gknd 10579 15 validation validation NN cord-010119-t1x9gknd 10579 16 performed perform VBN cord-010119-t1x9gknd 10579 17 . . . cord-010119-t1x9gknd 10580 1 This this DT cord-010119-t1x9gknd 10580 2 team team NN cord-010119-t1x9gknd 10580 3 also also RB cord-010119-t1x9gknd 10580 4 served serve VBD cord-010119-t1x9gknd 10580 5 as as IN cord-010119-t1x9gknd 10580 6 the the DT cord-010119-t1x9gknd 10580 7 subject subject JJ cord-010119-t1x9gknd 10580 8 matter matter NN cord-010119-t1x9gknd 10580 9 experts expert NNS cord-010119-t1x9gknd 10580 10 and and CC cord-010119-t1x9gknd 10580 11 field field NN cord-010119-t1x9gknd 10580 12 preceptors preceptor NNS cord-010119-t1x9gknd 10580 13 . . . cord-010119-t1x9gknd 10581 1 Fresenius Fresenius NNP cord-010119-t1x9gknd 10581 2 Kabi Kabi NNP cord-010119-t1x9gknd 10581 3 returned return VBD cord-010119-t1x9gknd 10581 4 for for IN cord-010119-t1x9gknd 10581 5 Advanced Advanced NNP cord-010119-t1x9gknd 10581 6 Alyx Alyx NNP cord-010119-t1x9gknd 10581 7 Operator Operator NNP cord-010119-t1x9gknd 10581 8 training training NN cord-010119-t1x9gknd 10581 9 . . . cord-010119-t1x9gknd 10582 1 The the DT cord-010119-t1x9gknd 10582 2 training training NN cord-010119-t1x9gknd 10582 3 plan plan NN cord-010119-t1x9gknd 10582 4 targeted target VBD cord-010119-t1x9gknd 10582 5 previous previous JJ cord-010119-t1x9gknd 10582 6 MCS1 MCS1 NNP cord-010119-t1x9gknd 10582 7 operators operator NNS cord-010119-t1x9gknd 10582 8 first first RB cord-010119-t1x9gknd 10582 9 and and CC cord-010119-t1x9gknd 10582 10 then then RB cord-010119-t1x9gknd 10582 11 operators operator NNS cord-010119-t1x9gknd 10582 12 new new JJ cord-010119-t1x9gknd 10582 13 to to TO cord-010119-t1x9gknd 10582 14 apheresis apheresis VB cord-010119-t1x9gknd 10582 15 with with IN cord-010119-t1x9gknd 10582 16 a a DT cord-010119-t1x9gknd 10582 17 training training NN cord-010119-t1x9gknd 10582 18 goal goal NN cord-010119-t1x9gknd 10582 19 of of IN cord-010119-t1x9gknd 10582 20 30 30 CD cord-010119-t1x9gknd 10582 21 % % NN cord-010119-t1x9gknd 10582 22 of of IN cord-010119-t1x9gknd 10582 23 mobile mobile JJ cord-010119-t1x9gknd 10582 24 staff staff NN cord-010119-t1x9gknd 10582 25 . . . cord-010119-t1x9gknd 10583 1 Validation validation NN cord-010119-t1x9gknd 10583 2 of of IN cord-010119-t1x9gknd 10583 3 the the DT cord-010119-t1x9gknd 10583 4 12 12 CD cord-010119-t1x9gknd 10583 5 Alyx Alyx NNP cord-010119-t1x9gknd 10583 6 began begin VBD cord-010119-t1x9gknd 10583 7 06/01/16 06/01/16 : cord-010119-t1x9gknd 10583 8 and and CC cord-010119-t1x9gknd 10583 9 took take VBD cord-010119-t1x9gknd 10583 10 approximately approximately RB cord-010119-t1x9gknd 10583 11 45 45 CD cord-010119-t1x9gknd 10583 12 days day NNS cord-010119-t1x9gknd 10583 13 to to TO cord-010119-t1x9gknd 10583 14 complete complete VB cord-010119-t1x9gknd 10583 15 . . . cord-010119-t1x9gknd 10584 1 During during IN cord-010119-t1x9gknd 10584 2 this this DT cord-010119-t1x9gknd 10584 3 time time NN cord-010119-t1x9gknd 10584 4 , , , cord-010119-t1x9gknd 10584 5 Fresenius Fresenius NNP cord-010119-t1x9gknd 10584 6 Kabi Kabi NNP cord-010119-t1x9gknd 10584 7 conducted conduct VBD cord-010119-t1x9gknd 10584 8 Alyx Alyx NNP cord-010119-t1x9gknd 10584 9 education education NN cord-010119-t1x9gknd 10584 10 and and CC cord-010119-t1x9gknd 10584 11 apheresis apheresis NN cord-010119-t1x9gknd 10584 12 recruitment recruitment NN cord-010119-t1x9gknd 10584 13 training training NN cord-010119-t1x9gknd 10584 14 to to IN cord-010119-t1x9gknd 10584 15 all all DT cord-010119-t1x9gknd 10584 16 Collection Collection NNP cord-010119-t1x9gknd 10584 17 and and CC cord-010119-t1x9gknd 10584 18 Recruitment Recruitment NNP cord-010119-t1x9gknd 10584 19 staff staff NN cord-010119-t1x9gknd 10584 20 . . . cord-010119-t1x9gknd 10585 1 The the DT cord-010119-t1x9gknd 10585 2 MCS1 MCS1 NNP cord-010119-t1x9gknd 10585 3 machines machine NNS cord-010119-t1x9gknd 10585 4 were be VBD cord-010119-t1x9gknd 10585 5 removed remove VBN cord-010119-t1x9gknd 10585 6 from from IN cord-010119-t1x9gknd 10585 7 service service NN cord-010119-t1x9gknd 10585 8 07/08/16 07/08/16 CD cord-010119-t1x9gknd 10585 9 . . . cord-010119-t1x9gknd 10586 1 Alyx Alyx NNP cord-010119-t1x9gknd 10586 2 Go Go NNP cord-010119-t1x9gknd 10586 3 - - HYPH cord-010119-t1x9gknd 10586 4 Live Live NNP cord-010119-t1x9gknd 10586 5 occurred occur VBD cord-010119-t1x9gknd 10586 6 07/13/16 07/13/16 CD cord-010119-t1x9gknd 10586 7 . . . cord-010119-t1x9gknd 10587 1 Additional additional JJ cord-010119-t1x9gknd 10587 2 operator operator NN cord-010119-t1x9gknd 10587 3 training training NN cord-010119-t1x9gknd 10587 4 continued continue VBD cord-010119-t1x9gknd 10587 5 through through IN cord-010119-t1x9gknd 10587 6 September September NNP cord-010119-t1x9gknd 10587 7 2016 2016 CD cord-010119-t1x9gknd 10587 8 . . . cord-010119-t1x9gknd 10588 1 Results result NNS cord-010119-t1x9gknd 10588 2 / / SYM cord-010119-t1x9gknd 10588 3 Finding finding NN cord-010119-t1x9gknd 10588 4 : : : cord-010119-t1x9gknd 10589 1 Due due IN cord-010119-t1x9gknd 10589 2 to to IN cord-010119-t1x9gknd 10589 3 ease ease NN cord-010119-t1x9gknd 10589 4 of of IN cord-010119-t1x9gknd 10589 5 mobility mobility NN cord-010119-t1x9gknd 10589 6 and and CC cord-010119-t1x9gknd 10589 7 use use NN cord-010119-t1x9gknd 10589 8 of of IN cord-010119-t1x9gknd 10589 9 Alyx Alyx NNP cord-010119-t1x9gknd 10589 10 , , , cord-010119-t1x9gknd 10589 11 reduced reduce VBN cord-010119-t1x9gknd 10589 12 procedure procedure NN cord-010119-t1x9gknd 10589 13 time time NN cord-010119-t1x9gknd 10589 14 compared compare VBN cord-010119-t1x9gknd 10589 15 to to IN cord-010119-t1x9gknd 10589 16 MCS1 MCS1 NNP cord-010119-t1x9gknd 10589 17 and and CC cord-010119-t1x9gknd 10589 18 donor donor NN cord-010119-t1x9gknd 10589 19 conversion conversion NN cord-010119-t1x9gknd 10589 20 training training NN cord-010119-t1x9gknd 10589 21 we -PRON- PRP cord-010119-t1x9gknd 10589 22 increase increase VBP cord-010119-t1x9gknd 10589 23 components component NNS cord-010119-t1x9gknd 10589 24 collected collect VBN cord-010119-t1x9gknd 10589 25 . . . cord-010119-t1x9gknd 10590 1 Alyx Alyx NNP cord-010119-t1x9gknd 10590 2 disposable disposable JJ cord-010119-t1x9gknd 10590 3 kit kit NN cord-010119-t1x9gknd 10590 4 includes include VBZ cord-010119-t1x9gknd 10590 5 pre pre JJ cord-010119-t1x9gknd 10590 6 - - JJ cord-010119-t1x9gknd 10590 7 attached attached JJ cord-010119-t1x9gknd 10590 8 solution solution NN cord-010119-t1x9gknd 10590 9 containers container NNS cord-010119-t1x9gknd 10590 10 reducing reduce VBG cord-010119-t1x9gknd 10590 11 ancillary ancillary JJ cord-010119-t1x9gknd 10590 12 items item NNS cord-010119-t1x9gknd 10590 13 required require VBN cord-010119-t1x9gknd 10590 14 to to TO cord-010119-t1x9gknd 10590 15 pack pack VB cord-010119-t1x9gknd 10590 16 and and CC cord-010119-t1x9gknd 10590 17 carry carry VB cord-010119-t1x9gknd 10590 18 to to IN cord-010119-t1x9gknd 10590 19 mobiles mobile NNS cord-010119-t1x9gknd 10590 20 . . . cord-010119-t1x9gknd 10591 1 This this DT cord-010119-t1x9gknd 10591 2 decreased decrease VBD cord-010119-t1x9gknd 10591 3 kit kit NN cord-010119-t1x9gknd 10591 4 cost cost NN cord-010119-t1x9gknd 10591 5 by by IN cord-010119-t1x9gknd 10591 6 $ $ $ cord-010119-t1x9gknd 10591 7 19.21 19.21 CD cord-010119-t1x9gknd 10591 8 each each DT cord-010119-t1x9gknd 10591 9 providing provide VBG cord-010119-t1x9gknd 10591 10 an an DT cord-010119-t1x9gknd 10591 11 estimated estimate VBN cord-010119-t1x9gknd 10591 12 annual annual JJ cord-010119-t1x9gknd 10591 13 savings saving NNS cord-010119-t1x9gknd 10591 14 of of IN cord-010119-t1x9gknd 10591 15 $ $ $ cord-010119-t1x9gknd 10591 16 239,000 239,000 CD cord-010119-t1x9gknd 10591 17 . . . cord-010119-t1x9gknd 10592 1 Conclusion conclusion NN cord-010119-t1x9gknd 10592 2 : : : cord-010119-t1x9gknd 10592 3 With with IN cord-010119-t1x9gknd 10592 4 the the DT cord-010119-t1x9gknd 10592 5 multiple multiple JJ cord-010119-t1x9gknd 10592 6 Alyx Alyx NNP cord-010119-t1x9gknd 10592 7 donation donation NN cord-010119-t1x9gknd 10592 8 types type NNS cord-010119-t1x9gknd 10592 9 we -PRON- PRP cord-010119-t1x9gknd 10592 10 were be VBD cord-010119-t1x9gknd 10592 11 able able JJ cord-010119-t1x9gknd 10592 12 to to TO cord-010119-t1x9gknd 10592 13 increase increase VB cord-010119-t1x9gknd 10592 14 our -PRON- PRP$ cord-010119-t1x9gknd 10592 15 collection collection NN cord-010119-t1x9gknd 10592 16 of of IN cord-010119-t1x9gknd 10592 17 right right JJ cord-010119-t1x9gknd 10592 18 type type NN cord-010119-t1x9gknd 10592 19 procedures procedure NNS cord-010119-t1x9gknd 10592 20 by by IN cord-010119-t1x9gknd 10592 21 approximately approximately RB cord-010119-t1x9gknd 10592 22 2.5 2.5 CD cord-010119-t1x9gknd 10592 23 % % NN cord-010119-t1x9gknd 10592 24 and and CC cord-010119-t1x9gknd 10592 25 decrease decrease VB cord-010119-t1x9gknd 10592 26 our -PRON- PRP$ cord-010119-t1x9gknd 10592 27 kit kit NN cord-010119-t1x9gknd 10592 28 costs cost NNS cord-010119-t1x9gknd 10592 29 by by IN cord-010119-t1x9gknd 10592 30 22 22 CD cord-010119-t1x9gknd 10592 31 % % NN cord-010119-t1x9gknd 10592 32 . . . cord-010119-t1x9gknd 10593 1 With with IN cord-010119-t1x9gknd 10593 2 Alyx Alyx NNP cord-010119-t1x9gknd 10593 3 the the DT cord-010119-t1x9gknd 10593 4 collection collection NN cord-010119-t1x9gknd 10593 5 plasma plasma NN cord-010119-t1x9gknd 10593 6 on on IN cord-010119-t1x9gknd 10593 7 mobile mobile JJ cord-010119-t1x9gknd 10593 8 blood blood NN cord-010119-t1x9gknd 10593 9 drives drive NNS cord-010119-t1x9gknd 10593 10 is be VBZ cord-010119-t1x9gknd 10593 11 now now RB cord-010119-t1x9gknd 10593 12 possible possible JJ cord-010119-t1x9gknd 10593 13 . . . cord-010119-t1x9gknd 10594 1 Due due IN cord-010119-t1x9gknd 10594 2 to to TO cord-010119-t1x9gknd 10594 3 ease ease NN cord-010119-t1x9gknd 10594 4 of of IN cord-010119-t1x9gknd 10594 5 use use NN cord-010119-t1x9gknd 10594 6 , , , cord-010119-t1x9gknd 10594 7 operators operator NNS cord-010119-t1x9gknd 10594 8 have have VBP cord-010119-t1x9gknd 10594 9 embraced embrace VBN cord-010119-t1x9gknd 10594 10 this this DT cord-010119-t1x9gknd 10594 11 technology technology NN cord-010119-t1x9gknd 10594 12 and and CC cord-010119-t1x9gknd 10594 13 we -PRON- PRP cord-010119-t1x9gknd 10594 14 have have VBP cord-010119-t1x9gknd 10594 15 consistently consistently RB cord-010119-t1x9gknd 10594 16 met meet VBN cord-010119-t1x9gknd 10594 17 our -PRON- PRP$ cord-010119-t1x9gknd 10594 18 monthly monthly JJ cord-010119-t1x9gknd 10594 19 collection collection NN cord-010119-t1x9gknd 10594 20 goals goal NNS cord-010119-t1x9gknd 10594 21 from from IN cord-010119-t1x9gknd 10594 22 October October NNP cord-010119-t1x9gknd 10594 23 2016-March 2016-march CD cord-010119-t1x9gknd 10594 24 2017 2017 CD cord-010119-t1x9gknd 10594 25 . . . cord-010119-t1x9gknd 10595 1 Background Background NNP cord-010119-t1x9gknd 10595 2 / / SYM cord-010119-t1x9gknd 10595 3 Case Case NNP cord-010119-t1x9gknd 10595 4 Studies Studies NNPS cord-010119-t1x9gknd 10595 5 : : : cord-010119-t1x9gknd 10596 1 High high JJ cord-010119-t1x9gknd 10596 2 frequency frequency NN cord-010119-t1x9gknd 10596 3 of of IN cord-010119-t1x9gknd 10596 4 donation donation NN cord-010119-t1x9gknd 10596 5 is be VBZ cord-010119-t1x9gknd 10596 6 a a DT cord-010119-t1x9gknd 10596 7 risk risk NN cord-010119-t1x9gknd 10596 8 factor factor NN cord-010119-t1x9gknd 10596 9 for for IN cord-010119-t1x9gknd 10596 10 iron iron NN cord-010119-t1x9gknd 10596 11 deficiency deficiency NN cord-010119-t1x9gknd 10596 12 . . . cord-010119-t1x9gknd 10597 1 Because because IN cord-010119-t1x9gknd 10597 2 females female NNS cord-010119-t1x9gknd 10597 3 ' ' POS cord-010119-t1x9gknd 10597 4 iron iron NN cord-010119-t1x9gknd 10597 5 stores store NNS cord-010119-t1x9gknd 10597 6 are be VBP cord-010119-t1x9gknd 10597 7 generally generally RB cord-010119-t1x9gknd 10597 8 lower low JJR cord-010119-t1x9gknd 10597 9 than than IN cord-010119-t1x9gknd 10597 10 males male NNS cord-010119-t1x9gknd 10597 11 ' ' '' cord-010119-t1x9gknd 10597 12 before before IN cord-010119-t1x9gknd 10597 13 they -PRON- PRP cord-010119-t1x9gknd 10597 14 start start VBP cord-010119-t1x9gknd 10597 15 their -PRON- PRP$ cord-010119-t1x9gknd 10597 16 donation donation NN cord-010119-t1x9gknd 10597 17 career career NN cord-010119-t1x9gknd 10597 18 , , , cord-010119-t1x9gknd 10597 19 females female NNS cord-010119-t1x9gknd 10597 20 who who WP cord-010119-t1x9gknd 10597 21 donate donate VBP cord-010119-t1x9gknd 10597 22 frequently frequently RB cord-010119-t1x9gknd 10597 23 are be VBP cord-010119-t1x9gknd 10597 24 particularly particularly RB cord-010119-t1x9gknd 10597 25 high high JJ cord-010119-t1x9gknd 10597 26 risk risk NN cord-010119-t1x9gknd 10597 27 . . . cord-010119-t1x9gknd 10598 1 Minimum minimum JJ cord-010119-t1x9gknd 10598 2 hemoglobin hemoglobin NN cord-010119-t1x9gknd 10598 3 ( ( -LRB- cord-010119-t1x9gknd 10598 4 Hb Hb NNP cord-010119-t1x9gknd 10598 5 ) ) -RRB- cord-010119-t1x9gknd 10598 6 has have VBZ cord-010119-t1x9gknd 10598 7 long long RB cord-010119-t1x9gknd 10598 8 been be VBN cord-010119-t1x9gknd 10598 9 the the DT cord-010119-t1x9gknd 10598 10 same same JJ cord-010119-t1x9gknd 10598 11 for for IN cord-010119-t1x9gknd 10598 12 males male NNS cord-010119-t1x9gknd 10598 13 and and CC cord-010119-t1x9gknd 10598 14 females female NNS cord-010119-t1x9gknd 10598 15 at at IN cord-010119-t1x9gknd 10598 16 125g 125g NNP cord-010119-t1x9gknd 10598 17 / / SYM cord-010119-t1x9gknd 10598 18 L L NNP cord-010119-t1x9gknd 10598 19 , , , cord-010119-t1x9gknd 10598 20 but but CC cord-010119-t1x9gknd 10598 21 for for IN cord-010119-t1x9gknd 10598 22 males male NNS cord-010119-t1x9gknd 10598 23 this this DT cord-010119-t1x9gknd 10598 24 falls fall VBZ cord-010119-t1x9gknd 10598 25 below below IN cord-010119-t1x9gknd 10598 26 the the DT cord-010119-t1x9gknd 10598 27 normal normal JJ cord-010119-t1x9gknd 10598 28 limit limit NN cord-010119-t1x9gknd 10598 29 . . . cord-010119-t1x9gknd 10599 1 As as IN cord-010119-t1x9gknd 10599 2 a a DT cord-010119-t1x9gknd 10599 3 first first JJ cord-010119-t1x9gknd 10599 4 step step NN cord-010119-t1x9gknd 10599 5 to to TO cord-010119-t1x9gknd 10599 6 mitigate mitigate VB cord-010119-t1x9gknd 10599 7 iron iron NN cord-010119-t1x9gknd 10599 8 deficiency deficiency NN cord-010119-t1x9gknd 10599 9 , , , cord-010119-t1x9gknd 10599 10 criteria criterion NNS cord-010119-t1x9gknd 10599 11 for for IN cord-010119-t1x9gknd 10599 12 whole whole JJ cord-010119-t1x9gknd 10599 13 blood blood NN cord-010119-t1x9gknd 10599 14 donors donor NNS cord-010119-t1x9gknd 10599 15 were be VBD cord-010119-t1x9gknd 10599 16 modified modify VBN cord-010119-t1x9gknd 10599 17 for for IN cord-010119-t1x9gknd 10599 18 males male NNS cord-010119-t1x9gknd 10599 19 ( ( -LRB- cord-010119-t1x9gknd 10599 20 minimum minimum JJ cord-010119-t1x9gknd 10599 21 Hb Hb NNP cord-010119-t1x9gknd 10599 22 increased increase VBD cord-010119-t1x9gknd 10599 23 to to IN cord-010119-t1x9gknd 10599 24 ! ! . cord-010119-t1x9gknd 10600 1 130 130 CD cord-010119-t1x9gknd 10600 2 g g NN cord-010119-t1x9gknd 10600 3 / / SYM cord-010119-t1x9gknd 10600 4 L l NN cord-010119-t1x9gknd 10600 5 ) ) -RRB- cord-010119-t1x9gknd 10601 1 and and CC cord-010119-t1x9gknd 10601 2 for for IN cord-010119-t1x9gknd 10601 3 females female NNS cord-010119-t1x9gknd 10601 4 ( ( -LRB- cord-010119-t1x9gknd 10601 5 minimum minimum JJ cord-010119-t1x9gknd 10601 6 interdonation interdonation NNP cord-010119-t1x9gknd 10601 7 interval interval NN cord-010119-t1x9gknd 10601 8 increased increase VBD cord-010119-t1x9gknd 10601 9 from from IN cord-010119-t1x9gknd 10601 10 56 56 CD cord-010119-t1x9gknd 10601 11 to to TO cord-010119-t1x9gknd 10601 12 84 84 CD cord-010119-t1x9gknd 10601 13 days day NNS cord-010119-t1x9gknd 10601 14 ) ) -RRB- cord-010119-t1x9gknd 10601 15 . . . cord-010119-t1x9gknd 10602 1 The the DT cord-010119-t1x9gknd 10602 2 longer long JJR cord-010119-t1x9gknd 10602 3 interdonation interdonation NN cord-010119-t1x9gknd 10602 4 interval interval NN cord-010119-t1x9gknd 10602 5 in in IN cord-010119-t1x9gknd 10602 6 females female NNS cord-010119-t1x9gknd 10602 7 was be VBD cord-010119-t1x9gknd 10602 8 gradually gradually RB cord-010119-t1x9gknd 10602 9 implemented implement VBN cord-010119-t1x9gknd 10602 10 , , , cord-010119-t1x9gknd 10602 11 starting start VBG cord-010119-t1x9gknd 10602 12 with with IN cord-010119-t1x9gknd 10602 13 donor donor NN cord-010119-t1x9gknd 10602 14 messaging messaging NN cord-010119-t1x9gknd 10602 15 in in IN cord-010119-t1x9gknd 10602 16 October October NNP cord-010119-t1x9gknd 10602 17 2016 2016 CD cord-010119-t1x9gknd 10602 18 , , , cord-010119-t1x9gknd 10602 19 changes change NNS cord-010119-t1x9gknd 10602 20 in in IN cord-010119-t1x9gknd 10602 21 rebooking rebooking NN cord-010119-t1x9gknd 10602 22 of of IN cord-010119-t1x9gknd 10602 23 donation donation NN cord-010119-t1x9gknd 10602 24 appointments appointment NNS cord-010119-t1x9gknd 10602 25 in in IN cord-010119-t1x9gknd 10602 26 December December NNP cord-010119-t1x9gknd 10602 27 2016 2016 CD cord-010119-t1x9gknd 10602 28 and and CC cord-010119-t1x9gknd 10602 29 culminating culminate VBG cord-010119-t1x9gknd 10602 30 with with IN cord-010119-t1x9gknd 10602 31 eProgesa eProgesa NNP cord-010119-t1x9gknd 10602 32 criteria criterion NNS cord-010119-t1x9gknd 10602 33 changes change NNS cord-010119-t1x9gknd 10602 34 on on IN cord-010119-t1x9gknd 10602 35 March March NNP cord-010119-t1x9gknd 10602 36 5 5 CD cord-010119-t1x9gknd 10602 37 , , , cord-010119-t1x9gknd 10602 38 2017 2017 CD cord-010119-t1x9gknd 10602 39 . . . cord-010119-t1x9gknd 10603 1 Both both CC cord-010119-t1x9gknd 10603 2 these these DT cord-010119-t1x9gknd 10603 3 changes change NNS cord-010119-t1x9gknd 10603 4 are be VBP cord-010119-t1x9gknd 10603 5 expected expect VBN cord-010119-t1x9gknd 10603 6 to to TO cord-010119-t1x9gknd 10603 7 initially initially RB cord-010119-t1x9gknd 10603 8 result result VB cord-010119-t1x9gknd 10603 9 in in IN cord-010119-t1x9gknd 10603 10 donation donation NN cord-010119-t1x9gknd 10603 11 loss loss NN cord-010119-t1x9gknd 10603 12 , , , cord-010119-t1x9gknd 10603 13 but but CC cord-010119-t1x9gknd 10603 14 may may MD cord-010119-t1x9gknd 10603 15 be be VB cord-010119-t1x9gknd 10603 16 partly partly RB cord-010119-t1x9gknd 10603 17 counteracted counteract VBN cord-010119-t1x9gknd 10603 18 by by IN cord-010119-t1x9gknd 10603 19 a a DT cord-010119-t1x9gknd 10603 20 decrease decrease NN cord-010119-t1x9gknd 10603 21 in in IN cord-010119-t1x9gknd 10603 22 Hb Hb NNP cord-010119-t1x9gknd 10603 23 deferral deferral NN cord-010119-t1x9gknd 10603 24 rates rate NNS cord-010119-t1x9gknd 10603 25 in in IN cord-010119-t1x9gknd 10603 26 female female JJ cord-010119-t1x9gknd 10603 27 donors donor NNS cord-010119-t1x9gknd 10603 28 . . . cord-010119-t1x9gknd 10604 1 We -PRON- PRP cord-010119-t1x9gknd 10604 2 aimed aim VBD cord-010119-t1x9gknd 10604 3 to to TO cord-010119-t1x9gknd 10604 4 assess assess VB cord-010119-t1x9gknd 10604 5 the the DT cord-010119-t1x9gknd 10604 6 impact impact NN cord-010119-t1x9gknd 10604 7 of of IN cord-010119-t1x9gknd 10604 8 these these DT cord-010119-t1x9gknd 10604 9 changes change NNS cord-010119-t1x9gknd 10604 10 on on IN cord-010119-t1x9gknd 10604 11 Hb Hb NNP cord-010119-t1x9gknd 10604 12 deferral deferral NN cord-010119-t1x9gknd 10604 13 rates rate NNS cord-010119-t1x9gknd 10604 14 . . . cord-010119-t1x9gknd 10605 1 Study Study NNP cord-010119-t1x9gknd 10605 2 Design Design NNP cord-010119-t1x9gknd 10605 3 / / SYM cord-010119-t1x9gknd 10605 4 Method method NN cord-010119-t1x9gknd 10605 5 : : : cord-010119-t1x9gknd 10606 1 Percentages percentage NNS cord-010119-t1x9gknd 10606 2 of of IN cord-010119-t1x9gknd 10606 3 Hb Hb NNP cord-010119-t1x9gknd 10606 4 deferrals deferral NNS cord-010119-t1x9gknd 10606 5 were be VBD cord-010119-t1x9gknd 10606 6 calculated calculate VBN cord-010119-t1x9gknd 10606 7 as as IN cord-010119-t1x9gknd 10606 8 the the DT cord-010119-t1x9gknd 10606 9 number number NN cord-010119-t1x9gknd 10606 10 of of IN cord-010119-t1x9gknd 10606 11 donation donation NN cord-010119-t1x9gknd 10606 12 attempts attempt NNS cord-010119-t1x9gknd 10606 13 that that WDT cord-010119-t1x9gknd 10606 14 resulted result VBD cord-010119-t1x9gknd 10606 15 in in IN cord-010119-t1x9gknd 10606 16 Hb Hb NNP cord-010119-t1x9gknd 10606 17 deferral deferral NN cord-010119-t1x9gknd 10606 18 divided divide VBN cord-010119-t1x9gknd 10606 19 by by IN cord-010119-t1x9gknd 10606 20 the the DT cord-010119-t1x9gknd 10606 21 number number NN cord-010119-t1x9gknd 10606 22 of of IN cord-010119-t1x9gknd 10606 23 successful successful JJ cord-010119-t1x9gknd 10606 24 donations donation NNS cord-010119-t1x9gknd 10606 25 plus plus CC cord-010119-t1x9gknd 10606 26 Hb Hb NNP cord-010119-t1x9gknd 10606 27 deferrals deferral NNS cord-010119-t1x9gknd 10606 28 multiplied multiply VBD cord-010119-t1x9gknd 10606 29 by by IN cord-010119-t1x9gknd 10606 30 100 100 CD cord-010119-t1x9gknd 10606 31 . . . cord-010119-t1x9gknd 10607 1 Percentages percentage NNS cord-010119-t1x9gknd 10607 2 were be VBD cord-010119-t1x9gknd 10607 3 calculated calculate VBN cord-010119-t1x9gknd 10607 4 for for IN cord-010119-t1x9gknd 10607 5 male male JJ cord-010119-t1x9gknd 10607 6 and and CC cord-010119-t1x9gknd 10607 7 female female JJ cord-010119-t1x9gknd 10607 8 donors donor NNS cord-010119-t1x9gknd 10607 9 before before IN cord-010119-t1x9gknd 10607 10 and and CC cord-010119-t1x9gknd 10607 11 after after IN cord-010119-t1x9gknd 10607 12 changes change NNS cord-010119-t1x9gknd 10607 13 were be VBD cord-010119-t1x9gknd 10607 14 made make VBN cord-010119-t1x9gknd 10607 15 . . . cord-010119-t1x9gknd 10608 1 Results/ Results/ . cord-010119-t1x9gknd 10609 1 Finding finding NN cord-010119-t1x9gknd 10609 2 : : : cord-010119-t1x9gknd 10610 1 The the DT cord-010119-t1x9gknd 10610 2 percentage percentage NN cord-010119-t1x9gknd 10610 3 of of IN cord-010119-t1x9gknd 10610 4 Hb Hb NNP cord-010119-t1x9gknd 10610 5 deferrals deferral NNS cord-010119-t1x9gknd 10610 6 increased increase VBD cord-010119-t1x9gknd 10610 7 in in IN cord-010119-t1x9gknd 10610 8 male male JJ cord-010119-t1x9gknd 10610 9 donors donor NNS cord-010119-t1x9gknd 10610 10 from from IN cord-010119-t1x9gknd 10610 11 0.89 0.89 CD cord-010119-t1x9gknd 10610 12 % % NN cord-010119-t1x9gknd 10610 13 in in IN cord-010119-t1x9gknd 10610 14 the the DT cord-010119-t1x9gknd 10610 15 3 3 CD cord-010119-t1x9gknd 10610 16 weeks week NNS cord-010119-t1x9gknd 10610 17 pre pre JJ cord-010119-t1x9gknd 10610 18 - - NN cord-010119-t1x9gknd 10610 19 implementation implementation NN cord-010119-t1x9gknd 10610 20 to to IN cord-010119-t1x9gknd 10610 21 2.16 2.16 CD cord-010119-t1x9gknd 10610 22 % % NN cord-010119-t1x9gknd 10610 23 in in IN cord-010119-t1x9gknd 10610 24 the the DT cord-010119-t1x9gknd 10610 25 3 3 CD cord-010119-t1x9gknd 10610 26 weeks week NNS cord-010119-t1x9gknd 10610 27 post post NN cord-010119-t1x9gknd 10610 28 - - NN cord-010119-t1x9gknd 10610 29 implementation implementation NN cord-010119-t1x9gknd 10610 30 of of IN cord-010119-t1x9gknd 10610 31 the the DT cord-010119-t1x9gknd 10610 32 change change NN cord-010119-t1x9gknd 10610 33 in in IN cord-010119-t1x9gknd 10610 34 the the DT cord-010119-t1x9gknd 10610 35 Hb Hb NNP cord-010119-t1x9gknd 10610 36 criterion criterion NN cord-010119-t1x9gknd 10610 37 . . . cord-010119-t1x9gknd 10611 1 Hb Hb NNP cord-010119-t1x9gknd 10611 2 deferral deferral NN cord-010119-t1x9gknd 10611 3 rates rate NNS cord-010119-t1x9gknd 10611 4 for for IN cord-010119-t1x9gknd 10611 5 female female JJ cord-010119-t1x9gknd 10611 6 donors donor NNS cord-010119-t1x9gknd 10611 7 were be VBD cord-010119-t1x9gknd 10611 8 12.6 12.6 CD cord-010119-t1x9gknd 10611 9 % % NN cord-010119-t1x9gknd 10611 10 in in IN cord-010119-t1x9gknd 10611 11 September September NNP cord-010119-t1x9gknd 10611 12 , , , cord-010119-t1x9gknd 10611 13 12.0 12.0 CD cord-010119-t1x9gknd 10611 14 % % NN cord-010119-t1x9gknd 10611 15 in in IN cord-010119-t1x9gknd 10611 16 October October NNP cord-010119-t1x9gknd 10611 17 / / SYM cord-010119-t1x9gknd 10611 18 November November NNP cord-010119-t1x9gknd 10611 19 , , , cord-010119-t1x9gknd 10611 20 and and CC cord-010119-t1x9gknd 10611 21 9.9 9.9 CD cord-010119-t1x9gknd 10611 22 % % NN cord-010119-t1x9gknd 10611 23 from from IN cord-010119-t1x9gknd 10611 24 December December NNP cord-010119-t1x9gknd 10611 25 to to IN cord-010119-t1x9gknd 10611 26 March March NNP cord-010119-t1x9gknd 10611 27 , , , cord-010119-t1x9gknd 10611 28 2017 2017 CD cord-010119-t1x9gknd 10611 29 . . . cord-010119-t1x9gknd 10612 1 Conclusion conclusion NN cord-010119-t1x9gknd 10612 2 : : : cord-010119-t1x9gknd 10613 1 Hb Hb NNP cord-010119-t1x9gknd 10613 2 deferral deferral NN cord-010119-t1x9gknd 10613 3 was be VBD cord-010119-t1x9gknd 10613 4 more more RBR cord-010119-t1x9gknd 10613 5 frequent frequent JJ cord-010119-t1x9gknd 10613 6 in in IN cord-010119-t1x9gknd 10613 7 male male JJ cord-010119-t1x9gknd 10613 8 donors donor NNS cord-010119-t1x9gknd 10613 9 after after IN cord-010119-t1x9gknd 10613 10 the the DT cord-010119-t1x9gknd 10613 11 minimum minimum NN cord-010119-t1x9gknd 10613 12 Hb Hb NNP cord-010119-t1x9gknd 10613 13 was be VBD cord-010119-t1x9gknd 10613 14 increased increase VBN cord-010119-t1x9gknd 10613 15 to to IN cord-010119-t1x9gknd 10613 16 130 130 CD cord-010119-t1x9gknd 10613 17 g g NN cord-010119-t1x9gknd 10613 18 / / SYM cord-010119-t1x9gknd 10613 19 L. L. NNP cord-010119-t1x9gknd 10614 1 The the DT cord-010119-t1x9gknd 10614 2 gradual gradual JJ cord-010119-t1x9gknd 10614 3 implementation implementation NN cord-010119-t1x9gknd 10614 4 of of IN cord-010119-t1x9gknd 10614 5 increased increase VBN cord-010119-t1x9gknd 10614 6 interdonation interdonation NN cord-010119-t1x9gknd 10614 7 interval interval NN cord-010119-t1x9gknd 10614 8 for for IN cord-010119-t1x9gknd 10614 9 females female NNS cord-010119-t1x9gknd 10614 10 resulted result VBD cord-010119-t1x9gknd 10614 11 in in IN cord-010119-t1x9gknd 10614 12 a a DT cord-010119-t1x9gknd 10614 13 reduction reduction NN cord-010119-t1x9gknd 10614 14 in in IN cord-010119-t1x9gknd 10614 15 deferrals deferral NNS cord-010119-t1x9gknd 10614 16 , , , cord-010119-t1x9gknd 10614 17 thus thus RB cord-010119-t1x9gknd 10614 18 the the DT cord-010119-t1x9gknd 10614 19 initial initial JJ cord-010119-t1x9gknd 10614 20 donation donation NN cord-010119-t1x9gknd 10614 21 loss loss NN cord-010119-t1x9gknd 10614 22 associated associate VBN cord-010119-t1x9gknd 10614 23 with with IN cord-010119-t1x9gknd 10614 24 this this DT cord-010119-t1x9gknd 10614 25 change change NN cord-010119-t1x9gknd 10614 26 may may MD cord-010119-t1x9gknd 10614 27 be be VB cord-010119-t1x9gknd 10614 28 partly partly RB cord-010119-t1x9gknd 10614 29 offset offset VBN cord-010119-t1x9gknd 10614 30 over over IN cord-010119-t1x9gknd 10614 31 time time NN cord-010119-t1x9gknd 10614 32 by by IN cord-010119-t1x9gknd 10614 33 decreased decrease VBN cord-010119-t1x9gknd 10614 34 Hb Hb NNP cord-010119-t1x9gknd 10614 35 deferrals deferral NNS cord-010119-t1x9gknd 10614 36 . . . cord-010119-t1x9gknd 10615 1 A a DT cord-010119-t1x9gknd 10615 2 longer long JJR cord-010119-t1x9gknd 10615 3 observation observation NN cord-010119-t1x9gknd 10615 4 period period NN cord-010119-t1x9gknd 10615 5 is be VBZ cord-010119-t1x9gknd 10615 6 necessary necessary JJ cord-010119-t1x9gknd 10615 7 to to TO cord-010119-t1x9gknd 10615 8 confirm confirm VB cord-010119-t1x9gknd 10615 9 these these DT cord-010119-t1x9gknd 10615 10 findings finding NNS cord-010119-t1x9gknd 10615 11 and and CC cord-010119-t1x9gknd 10615 12 assess assess VB cord-010119-t1x9gknd 10615 13 impact impact NN cord-010119-t1x9gknd 10615 14 on on IN cord-010119-t1x9gknd 10615 15 phenotyped phenotyped JJ cord-010119-t1x9gknd 10615 16 blood blood NN cord-010119-t1x9gknd 10615 17 and and CC cord-010119-t1x9gknd 10615 18 donor donor NN cord-010119-t1x9gknd 10615 19 retention retention NN cord-010119-t1x9gknd 10615 20 . . . cord-010119-t1x9gknd 10616 1 In in IN cord-010119-t1x9gknd 10616 2 the the DT cord-010119-t1x9gknd 10616 3 past past JJ cord-010119-t1x9gknd 10616 4 8 8 CD cord-010119-t1x9gknd 10616 5 years year NNS cord-010119-t1x9gknd 10616 6 , , , cord-010119-t1x9gknd 10616 7 59,223 59,223 CD cord-010119-t1x9gknd 10616 8 blood blood NN cord-010119-t1x9gknd 10616 9 products product NNS cord-010119-t1x9gknd 10616 10 , , , cord-010119-t1x9gknd 10616 11 derived derive VBN cord-010119-t1x9gknd 10616 12 from from IN cord-010119-t1x9gknd 10616 13 10,509 10,509 CD cord-010119-t1x9gknd 10616 14 procedures procedure NNS cord-010119-t1x9gknd 10616 15 , , , cord-010119-t1x9gknd 10616 16 were be VBD cord-010119-t1x9gknd 10616 17 distributed distribute VBN cord-010119-t1x9gknd 10616 18 to to IN cord-010119-t1x9gknd 10616 19 185 185 CD cord-010119-t1x9gknd 10616 20 different different JJ cord-010119-t1x9gknd 10616 21 investigators investigator NNS cord-010119-t1x9gknd 10616 22 in in IN cord-010119-t1x9gknd 10616 23 over over IN cord-010119-t1x9gknd 10616 24 200 200 CD cord-010119-t1x9gknd 10616 25 laboratories laboratory NNS cord-010119-t1x9gknd 10616 26 . . . cord-010119-t1x9gknd 10617 1 Whole whole JJ cord-010119-t1x9gknd 10617 2 blood blood NN cord-010119-t1x9gknd 10617 3 was be VBD cord-010119-t1x9gknd 10617 4 the the DT cord-010119-t1x9gknd 10617 5 most most RBS cord-010119-t1x9gknd 10617 6 common common JJ cord-010119-t1x9gknd 10617 7 product product NN cord-010119-t1x9gknd 10617 8 ( ( -LRB- cord-010119-t1x9gknd 10617 9 45.2 45.2 CD cord-010119-t1x9gknd 10617 10 % % NN cord-010119-t1x9gknd 10617 11 ) ) -RRB- cord-010119-t1x9gknd 10617 12 , , , cord-010119-t1x9gknd 10617 13 followed follow VBN cord-010119-t1x9gknd 10617 14 by by IN cord-010119-t1x9gknd 10617 15 unmanipulated unmanipulated JJ cord-010119-t1x9gknd 10617 16 mononuclear mononuclear JJ cord-010119-t1x9gknd 10617 17 cell cell NN cord-010119-t1x9gknd 10617 18 collections collection NNS cord-010119-t1x9gknd 10617 19 ( ( -LRB- cord-010119-t1x9gknd 10617 20 28.6 28.6 CD cord-010119-t1x9gknd 10617 21 % % NN cord-010119-t1x9gknd 10617 22 ) ) -RRB- cord-010119-t1x9gknd 10617 23 , , , cord-010119-t1x9gknd 10617 24 and and CC cord-010119-t1x9gknd 10617 25 elutriated elutriated JJ cord-010119-t1x9gknd 10617 26 monocytes monocyte NNS cord-010119-t1x9gknd 10617 27 or or CC cord-010119-t1x9gknd 10617 28 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 10617 29 ( ( -LRB- cord-010119-t1x9gknd 10617 30 19.8 19.8 CD cord-010119-t1x9gknd 10617 31 % % NN cord-010119-t1x9gknd 10617 32 ) ) -RRB- cord-010119-t1x9gknd 10617 33 . . . cord-010119-t1x9gknd 10618 1 Less less RBR cord-010119-t1x9gknd 10618 2 common common JJ cord-010119-t1x9gknd 10618 3 requests request NNS cord-010119-t1x9gknd 10618 4 included include VBD cord-010119-t1x9gknd 10618 5 platelets platelet NNS cord-010119-t1x9gknd 10618 6 ( ( -LRB- cord-010119-t1x9gknd 10618 7 2.5 2.5 CD cord-010119-t1x9gknd 10618 8 % % NN cord-010119-t1x9gknd 10618 9 ) ) -RRB- cord-010119-t1x9gknd 10618 10 , , , cord-010119-t1x9gknd 10618 11 plasma plasma NN cord-010119-t1x9gknd 10618 12 ( ( -LRB- cord-010119-t1x9gknd 10618 13 2.5 2.5 CD cord-010119-t1x9gknd 10618 14 % % NN cord-010119-t1x9gknd 10618 15 ) ) -RRB- cord-010119-t1x9gknd 10618 16 and and CC cord-010119-t1x9gknd 10618 17 granulocytes granulocyte NNS cord-010119-t1x9gknd 10618 18 ( ( -LRB- cord-010119-t1x9gknd 10618 19 0.8 0.8 CD cord-010119-t1x9gknd 10618 20 % % NN cord-010119-t1x9gknd 10618 21 ) ) -RRB- cord-010119-t1x9gknd 10618 22 . . . cord-010119-t1x9gknd 10619 1 Adverse adverse JJ cord-010119-t1x9gknd 10619 2 donor donor NN cord-010119-t1x9gknd 10619 3 reactions reaction NNS cord-010119-t1x9gknd 10619 4 were be VBD cord-010119-t1x9gknd 10619 5 infrequent infrequent JJ cord-010119-t1x9gknd 10619 6 ( ( -LRB- cord-010119-t1x9gknd 10619 7 0.33 0.33 CD cord-010119-t1x9gknd 10619 8 % % NN cord-010119-t1x9gknd 10619 9 of of IN cord-010119-t1x9gknd 10619 10 procedures procedure NNS cord-010119-t1x9gknd 10619 11 ) ) -RRB- cord-010119-t1x9gknd 10619 12 . . . cord-010119-t1x9gknd 10620 1 Conclusion conclusion NN cord-010119-t1x9gknd 10620 2 : : : cord-010119-t1x9gknd 10621 1 We -PRON- PRP cord-010119-t1x9gknd 10621 2 report report VBP cord-010119-t1x9gknd 10621 3 the the DT cord-010119-t1x9gknd 10621 4 feasibility feasibility NN cord-010119-t1x9gknd 10621 5 of of IN cord-010119-t1x9gknd 10621 6 a a DT cord-010119-t1x9gknd 10621 7 program program NN cord-010119-t1x9gknd 10621 8 for for IN cord-010119-t1x9gknd 10621 9 collecting collect VBG cord-010119-t1x9gknd 10621 10 and and CC cord-010119-t1x9gknd 10621 11 distributing distribute VBG cord-010119-t1x9gknd 10621 12 blood blood NN cord-010119-t1x9gknd 10621 13 for for IN cord-010119-t1x9gknd 10621 14 investigators investigator NNS cord-010119-t1x9gknd 10621 15 to to TO cord-010119-t1x9gknd 10621 16 obtain obtain VB cord-010119-t1x9gknd 10621 17 blood blood NN cord-010119-t1x9gknd 10621 18 components component NNS cord-010119-t1x9gknd 10621 19 for for IN cord-010119-t1x9gknd 10621 20 in in FW cord-010119-t1x9gknd 10621 21 vitro vitro FW cord-010119-t1x9gknd 10621 22 research research NN cord-010119-t1x9gknd 10621 23 use use NN cord-010119-t1x9gknd 10621 24 , , , cord-010119-t1x9gknd 10621 25 utilizing utilize VBG cord-010119-t1x9gknd 10621 26 the the DT cord-010119-t1x9gknd 10621 27 staff staff NN cord-010119-t1x9gknd 10621 28 and and CC cord-010119-t1x9gknd 10621 29 resources resource NNS cord-010119-t1x9gknd 10621 30 of of IN cord-010119-t1x9gknd 10621 31 a a DT cord-010119-t1x9gknd 10621 32 hospital hospital NN cord-010119-t1x9gknd 10621 33 - - HYPH cord-010119-t1x9gknd 10621 34 based base VBN cord-010119-t1x9gknd 10621 35 blood blood NN cord-010119-t1x9gknd 10621 36 bank bank NN cord-010119-t1x9gknd 10621 37 . . . cord-010119-t1x9gknd 10622 1 Research research NN cord-010119-t1x9gknd 10622 2 blood blood NN cord-010119-t1x9gknd 10622 3 donation donation NN cord-010119-t1x9gknd 10622 4 is be VBZ cord-010119-t1x9gknd 10622 5 essential essential JJ cord-010119-t1x9gknd 10622 6 to to TO cord-010119-t1x9gknd 10622 7 support support VB cord-010119-t1x9gknd 10622 8 laboratory laboratory NN cord-010119-t1x9gknd 10622 9 research research NN cord-010119-t1x9gknd 10622 10 and and CC cord-010119-t1x9gknd 10622 11 to to TO cord-010119-t1x9gknd 10622 12 maintain maintain VB cord-010119-t1x9gknd 10622 13 positive positive JJ cord-010119-t1x9gknd 10622 14 relationships relationship NNS cord-010119-t1x9gknd 10622 15 with with IN cord-010119-t1x9gknd 10622 16 donors donor NNS cord-010119-t1x9gknd 10622 17 who who WP cord-010119-t1x9gknd 10622 18 have have VBP cord-010119-t1x9gknd 10622 19 been be VBN cord-010119-t1x9gknd 10622 20 deferred defer VBN cord-010119-t1x9gknd 10622 21 from from IN cord-010119-t1x9gknd 10622 22 allogeneic allogeneic NN cord-010119-t1x9gknd 10622 23 transfusion transfusion NN cord-010119-t1x9gknd 10622 24 . . . cord-010119-t1x9gknd 10623 1 Hospital hospital NN cord-010119-t1x9gknd 10623 2 - - HYPH cord-010119-t1x9gknd 10623 3 Based Based NNP cord-010119-t1x9gknd 10623 4 Blood Blood NNP cord-010119-t1x9gknd 10623 5 Donor Donor NNP cord-010119-t1x9gknd 10623 6 Center Center NNP cord-010119-t1x9gknd 10623 7 's 's POS cord-010119-t1x9gknd 10623 8 Experience experience NN cord-010119-t1x9gknd 10623 9 with with IN cord-010119-t1x9gknd 10623 10 Implementing Implementing NNP cord-010119-t1x9gknd 10623 11 Platelet Platelet NNP cord-010119-t1x9gknd 10623 12 Pathogen Pathogen NNP cord-010119-t1x9gknd 10623 13 Reduction Reduction NNP cord-010119-t1x9gknd 10623 14 System System NNP cord-010119-t1x9gknd 10623 15 Kimberly Kimberly NNP cord-010119-t1x9gknd 10623 16 J J NNP cord-010119-t1x9gknd 10623 17 Duffy Duffy NNP cord-010119-t1x9gknd 10624 1 * * NFP cord-010119-t1x9gknd 10624 2 , , , cord-010119-t1x9gknd 10624 3 Mary Mary NNP cord-010119-t1x9gknd 10624 4 M M NNP cord-010119-t1x9gknd 10624 5 Benike Benike NNP cord-010119-t1x9gknd 10624 6 , , , cord-010119-t1x9gknd 10624 7 James James NNP cord-010119-t1x9gknd 10624 8 R R NNP cord-010119-t1x9gknd 10624 9 Stubbs Stubbs NNP cord-010119-t1x9gknd 10624 10 and and CC cord-010119-t1x9gknd 10624 11 Justin Justin NNP cord-010119-t1x9gknd 10624 12 D D NNP cord-010119-t1x9gknd 10624 13 Kreuter Kreuter NNP cord-010119-t1x9gknd 10624 14 . . . cord-010119-t1x9gknd 10625 1 Background Background NNP cord-010119-t1x9gknd 10625 2 / / SYM cord-010119-t1x9gknd 10625 3 Case Case NNP cord-010119-t1x9gknd 10625 4 Studies Studies NNPS cord-010119-t1x9gknd 10625 5 : : : cord-010119-t1x9gknd 10626 1 The the DT cord-010119-t1x9gknd 10626 2 safety safety NN cord-010119-t1x9gknd 10626 3 of of IN cord-010119-t1x9gknd 10626 4 platelet platelet NN cord-010119-t1x9gknd 10626 5 products product NNS cord-010119-t1x9gknd 10626 6 has have VBZ cord-010119-t1x9gknd 10626 7 been be VBN cord-010119-t1x9gknd 10626 8 continually continually RB cord-010119-t1x9gknd 10626 9 improving improve VBG cord-010119-t1x9gknd 10626 10 due due IN cord-010119-t1x9gknd 10626 11 to to IN cord-010119-t1x9gknd 10626 12 testing testing NN cord-010119-t1x9gknd 10626 13 despite despite IN cord-010119-t1x9gknd 10626 14 the the DT cord-010119-t1x9gknd 10626 15 continued continued JJ cord-010119-t1x9gknd 10626 16 emergence emergence NN cord-010119-t1x9gknd 10626 17 of of IN cord-010119-t1x9gknd 10626 18 microbial microbial JJ cord-010119-t1x9gknd 10626 19 threats threat NNS cord-010119-t1x9gknd 10626 20 . . . cord-010119-t1x9gknd 10627 1 The the DT cord-010119-t1x9gknd 10627 2 recent recent JJ cord-010119-t1x9gknd 10627 3 FDA FDA NNP cord-010119-t1x9gknd 10627 4 approval approval NN cord-010119-t1x9gknd 10627 5 of of IN cord-010119-t1x9gknd 10627 6 platelet platelet NN cord-010119-t1x9gknd 10627 7 pathogen pathogen NN cord-010119-t1x9gknd 10627 8 reduction reduction NN cord-010119-t1x9gknd 10627 9 technology technology NN cord-010119-t1x9gknd 10627 10 will will MD cord-010119-t1x9gknd 10627 11 protect protect VB cord-010119-t1x9gknd 10627 12 transfusion transfusion NN cord-010119-t1x9gknd 10627 13 recipients recipient NNS cord-010119-t1x9gknd 10627 14 regardless regardless RB cord-010119-t1x9gknd 10627 15 of of IN cord-010119-t1x9gknd 10627 16 the the DT cord-010119-t1x9gknd 10627 17 new new JJ cord-010119-t1x9gknd 10627 18 microbial microbial JJ cord-010119-t1x9gknd 10627 19 dangers danger NNS cord-010119-t1x9gknd 10627 20 . . . cord-010119-t1x9gknd 10628 1 In in IN cord-010119-t1x9gknd 10628 2 order order NN cord-010119-t1x9gknd 10628 3 for for IN cord-010119-t1x9gknd 10628 4 platelet platelet NN cord-010119-t1x9gknd 10628 5 products product NNS cord-010119-t1x9gknd 10628 6 to to TO cord-010119-t1x9gknd 10628 7 use use VB cord-010119-t1x9gknd 10628 8 the the DT cord-010119-t1x9gknd 10628 9 pathogen pathogen NN cord-010119-t1x9gknd 10628 10 reduction reduction NN cord-010119-t1x9gknd 10628 11 technology technology NN cord-010119-t1x9gknd 10628 12 , , , cord-010119-t1x9gknd 10628 13 the the DT cord-010119-t1x9gknd 10628 14 volume volume NN cord-010119-t1x9gknd 10628 15 , , , cord-010119-t1x9gknd 10628 16 platelet platelet NN cord-010119-t1x9gknd 10628 17 yield yield NN cord-010119-t1x9gknd 10628 18 ( ( -LRB- cord-010119-t1x9gknd 10628 19 dose dose NN cord-010119-t1x9gknd 10628 20 ) ) -RRB- cord-010119-t1x9gknd 10628 21 , , , cord-010119-t1x9gknd 10628 22 and and CC cord-010119-t1x9gknd 10628 23 concentration concentration NN cord-010119-t1x9gknd 10628 24 must must MD cord-010119-t1x9gknd 10628 25 be be VB cord-010119-t1x9gknd 10628 26 collected collect VBN cord-010119-t1x9gknd 10628 27 within within IN cord-010119-t1x9gknd 10628 28 tight tight JJ cord-010119-t1x9gknd 10628 29 specifications specification NNS cord-010119-t1x9gknd 10628 30 . . . cord-010119-t1x9gknd 10629 1 The the DT cord-010119-t1x9gknd 10629 2 objective objective NN cord-010119-t1x9gknd 10629 3 of of IN cord-010119-t1x9gknd 10629 4 this this DT cord-010119-t1x9gknd 10629 5 study study NN cord-010119-t1x9gknd 10629 6 was be VBD cord-010119-t1x9gknd 10629 7 to to TO cord-010119-t1x9gknd 10629 8 determine determine VB cord-010119-t1x9gknd 10629 9 the the DT cord-010119-t1x9gknd 10629 10 optimal optimal JJ cord-010119-t1x9gknd 10629 11 collection collection NN cord-010119-t1x9gknd 10629 12 settings setting NNS cord-010119-t1x9gknd 10629 13 to to TO cord-010119-t1x9gknd 10629 14 enable enable VB cord-010119-t1x9gknd 10629 15 100 100 CD cord-010119-t1x9gknd 10629 16 % % NN cord-010119-t1x9gknd 10629 17 collection collection NN cord-010119-t1x9gknd 10629 18 of of IN cord-010119-t1x9gknd 10629 19 pathogen pathogen NN cord-010119-t1x9gknd 10629 20 reduced reduce VBN cord-010119-t1x9gknd 10629 21 platelets platelet NNS cord-010119-t1x9gknd 10629 22 while while IN cord-010119-t1x9gknd 10629 23 limiting limit VBG cord-010119-t1x9gknd 10629 24 the the DT cord-010119-t1x9gknd 10629 25 loss loss NN cord-010119-t1x9gknd 10629 26 of of IN cord-010119-t1x9gknd 10629 27 products product NNS cord-010119-t1x9gknd 10629 28 . . . cord-010119-t1x9gknd 10630 1 Study Study NNP cord-010119-t1x9gknd 10630 2 Design Design NNP cord-010119-t1x9gknd 10630 3 / / SYM cord-010119-t1x9gknd 10630 4 Methods method NNS cord-010119-t1x9gknd 10630 5 : : : cord-010119-t1x9gknd 10630 6 The the DT cord-010119-t1x9gknd 10630 7 collection collection NN cord-010119-t1x9gknd 10630 8 instrument instrument NN cord-010119-t1x9gknd 10630 9 evaluated evaluate VBN cord-010119-t1x9gknd 10630 10 for for IN cord-010119-t1x9gknd 10630 11 this this DT cord-010119-t1x9gknd 10630 12 study study NN cord-010119-t1x9gknd 10630 13 has have VBZ cord-010119-t1x9gknd 10630 14 FDA FDA NNP cord-010119-t1x9gknd 10630 15 approval approval NN cord-010119-t1x9gknd 10630 16 for for IN cord-010119-t1x9gknd 10630 17 platelets platelet NNS cord-010119-t1x9gknd 10630 18 suspended suspend VBN cord-010119-t1x9gknd 10630 19 in in IN cord-010119-t1x9gknd 10630 20 100 100 CD cord-010119-t1x9gknd 10630 21 % % NN cord-010119-t1x9gknd 10630 22 plasma plasma NN cord-010119-t1x9gknd 10630 23 . . . cord-010119-t1x9gknd 10631 1 The the DT cord-010119-t1x9gknd 10631 2 corresponding correspond VBG cord-010119-t1x9gknd 10631 3 pathogen pathogen NN cord-010119-t1x9gknd 10631 4 reduction reduction NN cord-010119-t1x9gknd 10631 5 system system NN cord-010119-t1x9gknd 10631 6 used use VBN cord-010119-t1x9gknd 10631 7 for for IN cord-010119-t1x9gknd 10631 8 the the DT cord-010119-t1x9gknd 10631 9 study study NN cord-010119-t1x9gknd 10631 10 has have VBZ cord-010119-t1x9gknd 10631 11 3 3 CD cord-010119-t1x9gknd 10631 12 kits kit NNS cord-010119-t1x9gknd 10631 13 with with IN cord-010119-t1x9gknd 10631 14 3 3 CD cord-010119-t1x9gknd 10631 15 different different JJ cord-010119-t1x9gknd 10631 16 collection collection NN cord-010119-t1x9gknd 10631 17 specifications specification NNS cord-010119-t1x9gknd 10631 18 . . . cord-010119-t1x9gknd 10632 1 All all DT cord-010119-t1x9gknd 10632 2 apheresis apheresis NN cord-010119-t1x9gknd 10632 3 collections collection NNS cord-010119-t1x9gknd 10632 4 occurred occur VBD cord-010119-t1x9gknd 10632 5 at at IN cord-010119-t1x9gknd 10632 6 a a DT cord-010119-t1x9gknd 10632 7 fixed fix VBN cord-010119-t1x9gknd 10632 8 site site NN cord-010119-t1x9gknd 10632 9 and and CC cord-010119-t1x9gknd 10632 10 pre pre JJ cord-010119-t1x9gknd 10632 11 - - JJ cord-010119-t1x9gknd 10632 12 platelet platelet JJ cord-010119-t1x9gknd 10632 13 counts count NNS cord-010119-t1x9gknd 10632 14 were be VBD cord-010119-t1x9gknd 10632 15 performed perform VBN cord-010119-t1x9gknd 10632 16 on on IN cord-010119-t1x9gknd 10632 17 a a DT cord-010119-t1x9gknd 10632 18 hematology hematology NN cord-010119-t1x9gknd 10632 19 analyzer analyzer NN cord-010119-t1x9gknd 10632 20 . . . cord-010119-t1x9gknd 10633 1 The the DT cord-010119-t1x9gknd 10633 2 yield yield NN cord-010119-t1x9gknd 10633 3 scale scale NN cord-010119-t1x9gknd 10633 4 factor factor NN cord-010119-t1x9gknd 10633 5 has have VBZ cord-010119-t1x9gknd 10633 6 been be VBN cord-010119-t1x9gknd 10633 7 established establish VBN cord-010119-t1x9gknd 10633 8 for for IN cord-010119-t1x9gknd 10633 9 correlation correlation NN cord-010119-t1x9gknd 10633 10 between between IN cord-010119-t1x9gknd 10633 11 the the DT cord-010119-t1x9gknd 10633 12 hematology hematology NN cord-010119-t1x9gknd 10633 13 analyzer analyzer NN cord-010119-t1x9gknd 10633 14 and and CC cord-010119-t1x9gknd 10633 15 apheresis apheresis NN cord-010119-t1x9gknd 10633 16 collection collection NN cord-010119-t1x9gknd 10633 17 device device NN cord-010119-t1x9gknd 10633 18 . . . cord-010119-t1x9gknd 10634 1 In in IN cord-010119-t1x9gknd 10634 2 order order NN cord-010119-t1x9gknd 10634 3 to to TO cord-010119-t1x9gknd 10634 4 determine determine VB cord-010119-t1x9gknd 10634 5 the the DT cord-010119-t1x9gknd 10634 6 optimal optimal JJ cord-010119-t1x9gknd 10634 7 collection collection NN cord-010119-t1x9gknd 10634 8 targets target NNS cord-010119-t1x9gknd 10634 9 , , , cord-010119-t1x9gknd 10634 10 the the DT cord-010119-t1x9gknd 10634 11 apheresis apheresis NN cord-010119-t1x9gknd 10634 12 collection collection NN cord-010119-t1x9gknd 10634 13 instrument instrument NN cord-010119-t1x9gknd 10634 14 had have VBD cord-010119-t1x9gknd 10634 15 a a DT cord-010119-t1x9gknd 10634 16 variety variety NN cord-010119-t1x9gknd 10634 17 of of IN cord-010119-t1x9gknd 10634 18 multiple multiple JJ cord-010119-t1x9gknd 10634 19 yields yield NNS cord-010119-t1x9gknd 10634 20 and and CC cord-010119-t1x9gknd 10634 21 volumes volume NNS cord-010119-t1x9gknd 10634 22 established establish VBN cord-010119-t1x9gknd 10634 23 for for IN cord-010119-t1x9gknd 10634 24 collections collection NNS cord-010119-t1x9gknd 10634 25 . . . cord-010119-t1x9gknd 10635 1 Staff staff NN cord-010119-t1x9gknd 10635 2 was be VBD cord-010119-t1x9gknd 10635 3 instructed instruct VBN cord-010119-t1x9gknd 10635 4 to to TO cord-010119-t1x9gknd 10635 5 collect collect VB cord-010119-t1x9gknd 10635 6 the the DT cord-010119-t1x9gknd 10635 7 highest high JJS cord-010119-t1x9gknd 10635 8 available available JJ cord-010119-t1x9gknd 10635 9 yield yield NN cord-010119-t1x9gknd 10635 10 per per IN cord-010119-t1x9gknd 10635 11 donor donor NN cord-010119-t1x9gknd 10635 12 . . . cord-010119-t1x9gknd 10636 1 After after IN cord-010119-t1x9gknd 10636 2 collection collection NN cord-010119-t1x9gknd 10636 3 , , , cord-010119-t1x9gknd 10636 4 volume volume NN cord-010119-t1x9gknd 10636 5 , , , cord-010119-t1x9gknd 10636 6 platelet platelet NN cord-010119-t1x9gknd 10636 7 yield yield NN cord-010119-t1x9gknd 10636 8 , , , cord-010119-t1x9gknd 10636 9 and and CC cord-010119-t1x9gknd 10636 10 concentration concentration NN cord-010119-t1x9gknd 10636 11 data datum NNS cord-010119-t1x9gknd 10636 12 was be VBD cord-010119-t1x9gknd 10636 13 obtained obtain VBN cord-010119-t1x9gknd 10636 14 . . . cord-010119-t1x9gknd 10637 1 This this DT cord-010119-t1x9gknd 10637 2 data data NN cord-010119-t1x9gknd 10637 3 was be VBD cord-010119-t1x9gknd 10637 4 used use VBN cord-010119-t1x9gknd 10637 5 to to TO cord-010119-t1x9gknd 10637 6 determine determine VB cord-010119-t1x9gknd 10637 7 if if IN cord-010119-t1x9gknd 10637 8 the the DT cord-010119-t1x9gknd 10637 9 product product NN cord-010119-t1x9gknd 10637 10 met meet VBD cord-010119-t1x9gknd 10637 11 the the DT cord-010119-t1x9gknd 10637 12 specifications specification NNS cord-010119-t1x9gknd 10637 13 for for IN cord-010119-t1x9gknd 10637 14 one one CD cord-010119-t1x9gknd 10637 15 of of IN cord-010119-t1x9gknd 10637 16 the the DT cord-010119-t1x9gknd 10637 17 available available JJ cord-010119-t1x9gknd 10637 18 kits kit NNS cord-010119-t1x9gknd 10637 19 , , , cord-010119-t1x9gknd 10637 20 and and CC cord-010119-t1x9gknd 10637 21 if if IN cord-010119-t1x9gknd 10637 22 the the DT cord-010119-t1x9gknd 10637 23 actual actual JJ cord-010119-t1x9gknd 10637 24 platelet platelet NN cord-010119-t1x9gknd 10637 25 yield yield NN cord-010119-t1x9gknd 10637 26 was be VBD cord-010119-t1x9gknd 10637 27 higher high JJR cord-010119-t1x9gknd 10637 28 than than IN cord-010119-t1x9gknd 10637 29 6.8 6.8 CD cord-010119-t1x9gknd 10637 30 x10 x10 CD cord-010119-t1x9gknd 10637 31 11 11 CD cord-010119-t1x9gknd 10637 32 , , , cord-010119-t1x9gknd 10637 33 thus thus RB cord-010119-t1x9gknd 10637 34 meeting meet VBG cord-010119-t1x9gknd 10637 35 the the DT cord-010119-t1x9gknd 10637 36 criteria criterion NNS cord-010119-t1x9gknd 10637 37 for for IN cord-010119-t1x9gknd 10637 38 a a DT cord-010119-t1x9gknd 10637 39 double double JJ cord-010119-t1x9gknd 10637 40 product product NN cord-010119-t1x9gknd 10637 41 . . . cord-010119-t1x9gknd 10638 1 Results result NNS cord-010119-t1x9gknd 10638 2 / / SYM cord-010119-t1x9gknd 10638 3 Findings finding NNS cord-010119-t1x9gknd 10638 4 : : : cord-010119-t1x9gknd 10639 1 A a DT cord-010119-t1x9gknd 10639 2 higher high JJR cord-010119-t1x9gknd 10639 3 platelet platelet NN cord-010119-t1x9gknd 10639 4 concentration concentration NN cord-010119-t1x9gknd 10639 5 product product NN cord-010119-t1x9gknd 10639 6 is be VBZ cord-010119-t1x9gknd 10639 7 ideal ideal JJ cord-010119-t1x9gknd 10639 8 to to TO cord-010119-t1x9gknd 10639 9 produce produce VB cord-010119-t1x9gknd 10639 10 a a DT cord-010119-t1x9gknd 10639 11 double double JJ cord-010119-t1x9gknd 10639 12 product product NN cord-010119-t1x9gknd 10639 13 , , , cord-010119-t1x9gknd 10639 14 but but CC cord-010119-t1x9gknd 10639 15 targeting target VBG cord-010119-t1x9gknd 10639 16 products product NNS cord-010119-t1x9gknd 10639 17 with with IN cord-010119-t1x9gknd 10639 18 a a DT cord-010119-t1x9gknd 10639 19 platelet platelet NN cord-010119-t1x9gknd 10639 20 concentration concentration NN cord-010119-t1x9gknd 10639 21 greater great JJR cord-010119-t1x9gknd 10639 22 than than IN cord-010119-t1x9gknd 10639 23 1800 1800 CD cord-010119-t1x9gknd 10639 24 x x SYM cord-010119-t1x9gknd 10639 25 10 10 CD cord-010119-t1x9gknd 10639 26 3 3 CD cord-010119-t1x9gknd 10639 27 /mL /mL : cord-010119-t1x9gknd 10639 28 was be VBD cord-010119-t1x9gknd 10639 29 more more RBR cord-010119-t1x9gknd 10639 30 likely likely JJ cord-010119-t1x9gknd 10639 31 to to TO cord-010119-t1x9gknd 10639 32 be be VB cord-010119-t1x9gknd 10639 33 outside outside IN cord-010119-t1x9gknd 10639 34 the the DT cord-010119-t1x9gknd 10639 35 specification specification NN cord-010119-t1x9gknd 10639 36 of of IN cord-010119-t1x9gknd 10639 37 the the DT cord-010119-t1x9gknd 10639 38 pathogen pathogen NN cord-010119-t1x9gknd 10639 39 reduction reduction NN cord-010119-t1x9gknd 10639 40 kit kit NN cord-010119-t1x9gknd 10639 41 . . . cord-010119-t1x9gknd 10640 1 The the DT cord-010119-t1x9gknd 10640 2 platelet platelet NN cord-010119-t1x9gknd 10640 3 concentration concentration NN cord-010119-t1x9gknd 10640 4 target target NN cord-010119-t1x9gknd 10640 5 of of IN cord-010119-t1x9gknd 10640 6 1867 1867 CD cord-010119-t1x9gknd 10641 1 x x SYM cord-010119-t1x9gknd 10641 2 10 10 CD cord-010119-t1x9gknd 10641 3 3 3 CD cord-010119-t1x9gknd 10641 4 / / SYM cord-010119-t1x9gknd 10641 5 mL ml NN cord-010119-t1x9gknd 10641 6 results result NNS cord-010119-t1x9gknd 10641 7 in in IN cord-010119-t1x9gknd 10641 8 discarding discard VBG cord-010119-t1x9gknd 10641 9 products product NNS cord-010119-t1x9gknd 10641 10 and and CC cord-010119-t1x9gknd 10641 11 was be VBD cord-010119-t1x9gknd 10641 12 quickly quickly RB cord-010119-t1x9gknd 10641 13 removed remove VBN cord-010119-t1x9gknd 10641 14 from from IN cord-010119-t1x9gknd 10641 15 instrument instrument NN cord-010119-t1x9gknd 10641 16 settings setting NNS cord-010119-t1x9gknd 10641 17 . . . cord-010119-t1x9gknd 10642 1 Collections collection NNS cord-010119-t1x9gknd 10642 2 with with IN cord-010119-t1x9gknd 10642 3 a a DT cord-010119-t1x9gknd 10642 4 platelet platelet NN cord-010119-t1x9gknd 10642 5 yield yield NN cord-010119-t1x9gknd 10642 6 as as RB cord-010119-t1x9gknd 10642 7 low low JJ cord-010119-t1x9gknd 10642 8 as as IN cord-010119-t1x9gknd 10642 9 of of IN cord-010119-t1x9gknd 10642 10 3.5 3.5 CD cord-010119-t1x9gknd 10642 11 x10 x10 CD cord-010119-t1x9gknd 10642 12 11 11 CD cord-010119-t1x9gknd 10642 13 and and CC cord-010119-t1x9gknd 10642 14 platelet platelet NN cord-010119-t1x9gknd 10642 15 concentration concentration NN cord-010119-t1x9gknd 10642 16 of of IN cord-010119-t1x9gknd 10642 17 1167 1167 CD cord-010119-t1x9gknd 10642 18 x10 x10 CD cord-010119-t1x9gknd 10642 19 3 3 CD cord-010119-t1x9gknd 10642 20 /mL /mL , cord-010119-t1x9gknd 10642 21 were be VBD cord-010119-t1x9gknd 10642 22 more more RBR cord-010119-t1x9gknd 10642 23 likely likely JJ cord-010119-t1x9gknd 10642 24 to to TO cord-010119-t1x9gknd 10642 25 produce produce VB cord-010119-t1x9gknd 10642 26 a a DT cord-010119-t1x9gknd 10642 27 product product NN cord-010119-t1x9gknd 10642 28 that that WDT cord-010119-t1x9gknd 10642 29 was be VBD cord-010119-t1x9gknd 10642 30 not not RB cord-010119-t1x9gknd 10642 31 within within IN cord-010119-t1x9gknd 10642 32 the the DT cord-010119-t1x9gknd 10642 33 specification specification NN cord-010119-t1x9gknd 10642 34 of of IN cord-010119-t1x9gknd 10642 35 the the DT cord-010119-t1x9gknd 10642 36 pathogen pathogen NN cord-010119-t1x9gknd 10642 37 reduction reduction NN cord-010119-t1x9gknd 10642 38 kit kit NN cord-010119-t1x9gknd 10642 39 . . . cord-010119-t1x9gknd 10643 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 10643 2 Conclusion conclusion NN cord-010119-t1x9gknd 10643 3 : : : cord-010119-t1x9gknd 10644 1 The the DT cord-010119-t1x9gknd 10644 2 loss loss NN cord-010119-t1x9gknd 10644 3 of of IN cord-010119-t1x9gknd 10644 4 both both CC cord-010119-t1x9gknd 10644 5 triple triple JJ cord-010119-t1x9gknd 10644 6 platelet platelet NN cord-010119-t1x9gknd 10644 7 products product NNS cord-010119-t1x9gknd 10644 8 and and CC cord-010119-t1x9gknd 10644 9 lowered lower VBD cord-010119-t1x9gknd 10644 10 postprocessing postprocessing NN cord-010119-t1x9gknd 10644 11 platelet platelet NN cord-010119-t1x9gknd 10644 12 recovery recovery NN cord-010119-t1x9gknd 10644 13 requires require VBZ cord-010119-t1x9gknd 10644 14 the the DT cord-010119-t1x9gknd 10644 15 collection collection NN cord-010119-t1x9gknd 10644 16 of of IN cord-010119-t1x9gknd 10644 17 platelets platelet NNS cord-010119-t1x9gknd 10644 18 to to TO cord-010119-t1x9gknd 10644 19 be be VB cord-010119-t1x9gknd 10644 20 far far RB cord-010119-t1x9gknd 10644 21 more more RBR cord-010119-t1x9gknd 10644 22 precise precise JJ cord-010119-t1x9gknd 10644 23 . . . cord-010119-t1x9gknd 10645 1 The the DT cord-010119-t1x9gknd 10645 2 goal goal NN cord-010119-t1x9gknd 10645 3 of of IN cord-010119-t1x9gknd 10645 4 platelet platelet NN cord-010119-t1x9gknd 10645 5 collection collection NN cord-010119-t1x9gknd 10645 6 has have VBZ cord-010119-t1x9gknd 10645 7 shifted shift VBN cord-010119-t1x9gknd 10645 8 from from IN cord-010119-t1x9gknd 10645 9 simply simply RB cord-010119-t1x9gknd 10645 10 maximizing maximize VBG cord-010119-t1x9gknd 10645 11 each each DT cord-010119-t1x9gknd 10645 12 platelet platelet NN cord-010119-t1x9gknd 10645 13 collection collection NN cord-010119-t1x9gknd 10645 14 to to IN cord-010119-t1x9gknd 10645 15 an an DT cord-010119-t1x9gknd 10645 16 approach approach NN cord-010119-t1x9gknd 10645 17 that that WDT cord-010119-t1x9gknd 10645 18 considers consider VBZ cord-010119-t1x9gknd 10645 19 optimal optimal JJ cord-010119-t1x9gknd 10645 20 collection collection NN cord-010119-t1x9gknd 10645 21 within within IN cord-010119-t1x9gknd 10645 22 the the DT cord-010119-t1x9gknd 10645 23 limits limit NNS cord-010119-t1x9gknd 10645 24 of of IN cord-010119-t1x9gknd 10645 25 kit kit NN cord-010119-t1x9gknd 10645 26 specifications specification NNS cord-010119-t1x9gknd 10645 27 . . . cord-010119-t1x9gknd 10646 1 Final final JJ cord-010119-t1x9gknd 10646 2 collection collection NN cord-010119-t1x9gknd 10646 3 instrument instrument NN cord-010119-t1x9gknd 10646 4 configurations configuration NNS cord-010119-t1x9gknd 10646 5 are be VBP cord-010119-t1x9gknd 10646 6 platelet platelet NN cord-010119-t1x9gknd 10646 7 yield yield NN cord-010119-t1x9gknd 10646 8 of of IN cord-010119-t1x9gknd 10646 9 7.0 7.0 CD cord-010119-t1x9gknd 10646 10 x10 x10 CD cord-010119-t1x9gknd 10646 11 11 11 CD cord-010119-t1x9gknd 10646 12 and and CC cord-010119-t1x9gknd 10646 13 6.8 6.8 CD cord-010119-t1x9gknd 10646 14 x10 x10 CD cord-010119-t1x9gknd 10646 15 11 11 CD cord-010119-t1x9gknd 10646 16 at at IN cord-010119-t1x9gknd 10646 17 the the DT cord-010119-t1x9gknd 10646 18 volume volume NN cord-010119-t1x9gknd 10646 19 of of IN cord-010119-t1x9gknd 10646 20 400 400 CD cord-010119-t1x9gknd 10646 21 mls mls NN cord-010119-t1x9gknd 10646 22 and and CC cord-010119-t1x9gknd 10646 23 platelet platelet NN cord-010119-t1x9gknd 10646 24 yield yield NN cord-010119-t1x9gknd 10646 25 of of IN cord-010119-t1x9gknd 10646 26 4.2 4.2 CD cord-010119-t1x9gknd 10646 27 x10 x10 CD cord-010119-t1x9gknd 10646 28 11 11 CD cord-010119-t1x9gknd 10646 29 , , , cord-010119-t1x9gknd 10646 30 4.0 4.0 CD cord-010119-t1x9gknd 10646 31 x10 x10 CD cord-010119-t1x9gknd 10646 32 11 11 CD cord-010119-t1x9gknd 10646 33 , , , cord-010119-t1x9gknd 10646 34 and and CC cord-010119-t1x9gknd 10646 35 3.5 3.5 CD cord-010119-t1x9gknd 10646 36 x10 x10 CD cord-010119-t1x9gknd 10646 37 11 11 CD cord-010119-t1x9gknd 10646 38 at at IN cord-010119-t1x9gknd 10646 39 the the DT cord-010119-t1x9gknd 10646 40 volume volume NN cord-010119-t1x9gknd 10646 41 of of IN cord-010119-t1x9gknd 10646 42 300 300 CD cord-010119-t1x9gknd 10646 43 mls mls NN cord-010119-t1x9gknd 10646 44 . . . cord-010119-t1x9gknd 10647 1 Moving move VBG cord-010119-t1x9gknd 10647 2 from from IN cord-010119-t1x9gknd 10647 3 Subjective subjective JJ cord-010119-t1x9gknd 10647 4 to to IN cord-010119-t1x9gknd 10647 5 Objective Objective NNP cord-010119-t1x9gknd 10647 6 Donor Donor NNP cord-010119-t1x9gknd 10647 7 Eligibility Eligibility NNP cord-010119-t1x9gknd 10647 8 Screening Screening NNP cord-010119-t1x9gknd 10647 9 Platforms Platforms NNPS cord-010119-t1x9gknd 10647 10 : : : cord-010119-t1x9gknd 10648 1 A a DT cord-010119-t1x9gknd 10648 2 Blood Blood NNP cord-010119-t1x9gknd 10648 3 Center Center NNP cord-010119-t1x9gknd 10648 4 's 's POS cord-010119-t1x9gknd 10648 5 Journey Journey NNP cord-010119-t1x9gknd 10648 6 Angela Angela NNP cord-010119-t1x9gknd 10648 7 Dirr Dirr NNP cord-010119-t1x9gknd 10649 1 * * NFP cord-010119-t1x9gknd 10649 2 1 1 CD cord-010119-t1x9gknd 10649 3 and and CC cord-010119-t1x9gknd 10649 4 Steve Steve NNP cord-010119-t1x9gknd 10649 5 Cihura Cihura NNP cord-010119-t1x9gknd 10649 6 2 2 CD cord-010119-t1x9gknd 10649 7 . . . cord-010119-t1x9gknd 10649 8 1 1 CD cord-010119-t1x9gknd 10649 9 Bonfils Bonfils NNP cord-010119-t1x9gknd 10649 10 Blood Blood NNP cord-010119-t1x9gknd 10649 11 Center Center NNP cord-010119-t1x9gknd 10649 12 , , , cord-010119-t1x9gknd 10649 13 2 2 CD cord-010119-t1x9gknd 10649 14 BBC BBC NNP cord-010119-t1x9gknd 10649 15 / / SYM cord-010119-t1x9gknd 10649 16 BSI BSI NNP cord-010119-t1x9gknd 10649 17 Background Background NNP cord-010119-t1x9gknd 10649 18 / / SYM cord-010119-t1x9gknd 10649 19 Case Case NNP cord-010119-t1x9gknd 10649 20 Studies Studies NNPS cord-010119-t1x9gknd 10649 21 : : : cord-010119-t1x9gknd 10650 1 In in IN cord-010119-t1x9gknd 10650 2 2012 2012 CD cord-010119-t1x9gknd 10650 3 , , , cord-010119-t1x9gknd 10650 4 the the DT cord-010119-t1x9gknd 10650 5 device device NN cord-010119-t1x9gknd 10650 6 used use VBN cord-010119-t1x9gknd 10650 7 by by IN cord-010119-t1x9gknd 10650 8 Bonfils Bonfils NNP cord-010119-t1x9gknd 10650 9 Blood Blood NNP cord-010119-t1x9gknd 10650 10 Center Center NNP cord-010119-t1x9gknd 10650 11 to to TO cord-010119-t1x9gknd 10650 12 determine determine VB cord-010119-t1x9gknd 10650 13 donor donor NN cord-010119-t1x9gknd 10650 14 hemoglobin hemoglobin NN cord-010119-t1x9gknd 10650 15 and and CC cord-010119-t1x9gknd 10650 16 donor donor NN cord-010119-t1x9gknd 10650 17 eligibility eligibility NN cord-010119-t1x9gknd 10650 18 was be VBD cord-010119-t1x9gknd 10650 19 reaching reach VBG cord-010119-t1x9gknd 10650 20 its -PRON- PRP$ cord-010119-t1x9gknd 10650 21 end end NN cord-010119-t1x9gknd 10650 22 of of IN cord-010119-t1x9gknd 10650 23 life life NN cord-010119-t1x9gknd 10650 24 , , , cord-010119-t1x9gknd 10650 25 and and CC cord-010119-t1x9gknd 10650 26 BBC BBC NNP cord-010119-t1x9gknd 10650 27 needed need VBD cord-010119-t1x9gknd 10650 28 to to TO cord-010119-t1x9gknd 10650 29 define define VB cord-010119-t1x9gknd 10650 30 a a DT cord-010119-t1x9gknd 10650 31 path path NN cord-010119-t1x9gknd 10650 32 forward forward RB cord-010119-t1x9gknd 10650 33 for for IN cord-010119-t1x9gknd 10650 34 a a DT cord-010119-t1x9gknd 10650 35 reliable reliable JJ cord-010119-t1x9gknd 10650 36 replacement replacement NN cord-010119-t1x9gknd 10650 37 device device NN cord-010119-t1x9gknd 10650 38 . . . cord-010119-t1x9gknd 10651 1 Study Study NNP cord-010119-t1x9gknd 10651 2 Design Design NNP cord-010119-t1x9gknd 10651 3 / / SYM cord-010119-t1x9gknd 10651 4 Method method NN cord-010119-t1x9gknd 10651 5 : : : cord-010119-t1x9gknd 10651 6 BBC BBC NNP cord-010119-t1x9gknd 10651 7 evaluated evaluate VBD cord-010119-t1x9gknd 10651 8 3 3 CD cord-010119-t1x9gknd 10651 9 devices device NNS cord-010119-t1x9gknd 10651 10 with with IN cord-010119-t1x9gknd 10651 11 the the DT cord-010119-t1x9gknd 10651 12 following follow VBG cord-010119-t1x9gknd 10651 13 criteria criterion NNS cord-010119-t1x9gknd 10651 14 in in IN cord-010119-t1x9gknd 10651 15 mind mind NN cord-010119-t1x9gknd 10651 16 : : : cord-010119-t1x9gknd 10651 17 1 1 LS cord-010119-t1x9gknd 10651 18 ) ) -RRB- cord-010119-t1x9gknd 10651 19 device device NN cord-010119-t1x9gknd 10651 20 disposable disposable JJ cord-010119-t1x9gknd 10651 21 costs cost NNS cord-010119-t1x9gknd 10651 22 , , , cord-010119-t1x9gknd 10652 1 2 2 LS cord-010119-t1x9gknd 10652 2 ) ) -RRB- cord-010119-t1x9gknd 10652 3 reagents reagent NNS cord-010119-t1x9gknd 10652 4 / / SYM cord-010119-t1x9gknd 10652 5 controls control NNS cord-010119-t1x9gknd 10652 6 / / SYM cord-010119-t1x9gknd 10652 7 quality quality NN cord-010119-t1x9gknd 10652 8 control control NN cord-010119-t1x9gknd 10652 9 , , , cord-010119-t1x9gknd 10652 10 3 3 CD cord-010119-t1x9gknd 10652 11 ) ) -RRB- cord-010119-t1x9gknd 10652 12 objective objective JJ cord-010119-t1x9gknd 10652 13 Hgb Hgb NNP cord-010119-t1x9gknd 10652 14 / / SYM cord-010119-t1x9gknd 10652 15 Hct Hct NNP cord-010119-t1x9gknd 10652 16 measurement measurement NN cord-010119-t1x9gknd 10652 17 , , , cord-010119-t1x9gknd 10652 18 4 4 CD cord-010119-t1x9gknd 10652 19 ) ) -RRB- cord-010119-t1x9gknd 10652 20 portability portability NN cord-010119-t1x9gknd 10652 21 and and CC cord-010119-t1x9gknd 10652 22 durability durability NN cord-010119-t1x9gknd 10652 23 for for IN cord-010119-t1x9gknd 10652 24 a a DT cord-010119-t1x9gknd 10652 25 mobile mobile JJ cord-010119-t1x9gknd 10652 26 environment environment NN cord-010119-t1x9gknd 10652 27 , , , cord-010119-t1x9gknd 10652 28 5 5 LS cord-010119-t1x9gknd 10652 29 ) ) -RRB- cord-010119-t1x9gknd 10652 30 ease ease NN cord-010119-t1x9gknd 10652 31 of of IN cord-010119-t1x9gknd 10652 32 use use NN cord-010119-t1x9gknd 10652 33 , , , cord-010119-t1x9gknd 10652 34 6 6 CD cord-010119-t1x9gknd 10652 35 ) ) -RRB- cord-010119-t1x9gknd 10652 36 donor donor NN cord-010119-t1x9gknd 10652 37 experience experience NN cord-010119-t1x9gknd 10652 38 , , , cord-010119-t1x9gknd 10653 1 7 7 LS cord-010119-t1x9gknd 10653 2 ) ) -RRB- cord-010119-t1x9gknd 10653 3 battery battery NN cord-010119-t1x9gknd 10653 4 life life NN cord-010119-t1x9gknd 10653 5 , , , cord-010119-t1x9gknd 10653 6 8) 8) NN cord-010119-t1x9gknd 10653 7 validation validation NN cord-010119-t1x9gknd 10653 8 requirements requirement NNS cord-010119-t1x9gknd 10653 9 plans plan NNS cord-010119-t1x9gknd 10653 10 , , , cord-010119-t1x9gknd 10653 11 9 9 CD cord-010119-t1x9gknd 10653 12 ) ) -RRB- cord-010119-t1x9gknd 10653 13 blood blood NN cord-010119-t1x9gknd 10653 14 center center NN cord-010119-t1x9gknd 10653 15 suitability suitability NN cord-010119-t1x9gknd 10653 16 , , , cord-010119-t1x9gknd 10653 17 and and CC cord-010119-t1x9gknd 10653 18 10 10 CD cord-010119-t1x9gknd 10653 19 ) ) -RRB- cord-010119-t1x9gknd 10653 20 ability ability NN cord-010119-t1x9gknd 10653 21 to to TO cord-010119-t1x9gknd 10653 22 link link VB cord-010119-t1x9gknd 10653 23 to to IN cord-010119-t1x9gknd 10653 24 BECS BECS NNP cord-010119-t1x9gknd 10653 25 . . . cord-010119-t1x9gknd 10654 1 Multiple multiple JJ cord-010119-t1x9gknd 10654 2 departments department NNS cord-010119-t1x9gknd 10654 3 including include VBG cord-010119-t1x9gknd 10654 4 Donor Donor NNP cord-010119-t1x9gknd 10654 5 Care Care NNP cord-010119-t1x9gknd 10654 6 , , , cord-010119-t1x9gknd 10654 7 Equipment Equipment NNP cord-010119-t1x9gknd 10654 8 Management Management NNP cord-010119-t1x9gknd 10654 9 and and CC cord-010119-t1x9gknd 10654 10 Validation Validation NNP cord-010119-t1x9gknd 10654 11 , , , cord-010119-t1x9gknd 10654 12 Quality Quality NNP cord-010119-t1x9gknd 10654 13 , , , cord-010119-t1x9gknd 10654 14 and and CC cord-010119-t1x9gknd 10654 15 Regulatory Regulatory NNP cord-010119-t1x9gknd 10654 16 Affairs Affairs NNPS cord-010119-t1x9gknd 10654 17 were be VBD cord-010119-t1x9gknd 10654 18 involved involve VBN cord-010119-t1x9gknd 10654 19 in in IN cord-010119-t1x9gknd 10654 20 the the DT cord-010119-t1x9gknd 10654 21 evaluation evaluation NN cord-010119-t1x9gknd 10654 22 and and CC cord-010119-t1x9gknd 10654 23 product product NN cord-010119-t1x9gknd 10654 24 selection selection NN cord-010119-t1x9gknd 10654 25 . . . cord-010119-t1x9gknd 10655 1 BBC BBC NNP cord-010119-t1x9gknd 10655 2 tested test VBD cord-010119-t1x9gknd 10655 3 50 50 CD cord-010119-t1x9gknd 10655 4 donors donor NNS cord-010119-t1x9gknd 10655 5 per per IN cord-010119-t1x9gknd 10655 6 each each DT cord-010119-t1x9gknd 10655 7 device device NN cord-010119-t1x9gknd 10655 8 at at IN cord-010119-t1x9gknd 10655 9 both both CC cord-010119-t1x9gknd 10655 10 a a DT cord-010119-t1x9gknd 10655 11 fixed fix VBN cord-010119-t1x9gknd 10655 12 and and CC cord-010119-t1x9gknd 10655 13 a a DT cord-010119-t1x9gknd 10655 14 mobile mobile JJ cord-010119-t1x9gknd 10655 15 site site NN cord-010119-t1x9gknd 10655 16 . . . cord-010119-t1x9gknd 10656 1 BBC BBC NNP cord-010119-t1x9gknd 10656 2 also also RB cord-010119-t1x9gknd 10656 3 considered consider VBD cord-010119-t1x9gknd 10656 4 donor donor NN cord-010119-t1x9gknd 10656 5 feedback feedback NN cord-010119-t1x9gknd 10656 6 for for IN cord-010119-t1x9gknd 10656 7 the the DT cord-010119-t1x9gknd 10656 8 choice choice NN cord-010119-t1x9gknd 10656 9 of of IN cord-010119-t1x9gknd 10656 10 replacement replacement NN cord-010119-t1x9gknd 10656 11 technology technology NN cord-010119-t1x9gknd 10656 12 . . . cord-010119-t1x9gknd 10657 1 The the DT cord-010119-t1x9gknd 10657 2 project project NN cord-010119-t1x9gknd 10657 3 started start VBD cord-010119-t1x9gknd 10657 4 February February NNP cord-010119-t1x9gknd 10657 5 2013 2013 CD cord-010119-t1x9gknd 10657 6 with with IN cord-010119-t1x9gknd 10657 7 a a DT cord-010119-t1x9gknd 10657 8 targeted target VBN cord-010119-t1x9gknd 10657 9 implementation implementation NN cord-010119-t1x9gknd 10657 10 date date NN cord-010119-t1x9gknd 10657 11 of of IN cord-010119-t1x9gknd 10657 12 July July NNP cord-010119-t1x9gknd 10657 13 2013 2013 CD cord-010119-t1x9gknd 10657 14 . . . cord-010119-t1x9gknd 10658 1 After after IN cord-010119-t1x9gknd 10658 2 creating create VBG cord-010119-t1x9gknd 10658 3 necessary necessary JJ cord-010119-t1x9gknd 10658 4 SOPs sop NNS cord-010119-t1x9gknd 10658 5 and and CC cord-010119-t1x9gknd 10658 6 adopting adopt VBG cord-010119-t1x9gknd 10658 7 existing exist VBG cord-010119-t1x9gknd 10658 8 SOPs sop NNS cord-010119-t1x9gknd 10658 9 , , , cord-010119-t1x9gknd 10658 10 BBC BBC NNP cord-010119-t1x9gknd 10658 11 successfully successfully RB cord-010119-t1x9gknd 10658 12 completed complete VBD cord-010119-t1x9gknd 10658 13 the the DT cord-010119-t1x9gknd 10658 14 validation validation NN cord-010119-t1x9gknd 10658 15 of of IN cord-010119-t1x9gknd 10658 16 the the DT cord-010119-t1x9gknd 10658 17 devices device NNS cord-010119-t1x9gknd 10658 18 , , , cord-010119-t1x9gknd 10658 19 and and CC cord-010119-t1x9gknd 10658 20 chose choose VBD cord-010119-t1x9gknd 10658 21 the the DT cord-010119-t1x9gknd 10658 22 CompoLab CompoLab NNP cord-010119-t1x9gknd 10658 23 technology technology NN cord-010119-t1x9gknd 10658 24 from from IN cord-010119-t1x9gknd 10658 25 Fresenius Fresenius NNP cord-010119-t1x9gknd 10658 26 Kabi Kabi NNP cord-010119-t1x9gknd 10658 27 as as IN cord-010119-t1x9gknd 10658 28 the the DT cord-010119-t1x9gknd 10658 29 new new JJ cord-010119-t1x9gknd 10658 30 device device NN cord-010119-t1x9gknd 10658 31 for for IN cord-010119-t1x9gknd 10658 32 BBC BBC NNP cord-010119-t1x9gknd 10658 33 blood blood NN cord-010119-t1x9gknd 10658 34 bank bank NN cord-010119-t1x9gknd 10658 35 . . . cord-010119-t1x9gknd 10659 1 Results/ Results/ . cord-010119-t1x9gknd 10660 1 Finding finding NN cord-010119-t1x9gknd 10660 2 : : : cord-010119-t1x9gknd 10661 1 The the DT cord-010119-t1x9gknd 10661 2 CompoLab CompoLab NNP cord-010119-t1x9gknd 10661 3 was be VBD cord-010119-t1x9gknd 10661 4 selected select VBN cord-010119-t1x9gknd 10661 5 as as IN cord-010119-t1x9gknd 10661 6 it -PRON- PRP cord-010119-t1x9gknd 10661 7 met meet VBD cord-010119-t1x9gknd 10661 8 project project NN cord-010119-t1x9gknd 10661 9 scope scope NN cord-010119-t1x9gknd 10661 10 and and CC cord-010119-t1x9gknd 10661 11 selection selection NN cord-010119-t1x9gknd 10661 12 criteria criterion NNS cord-010119-t1x9gknd 10661 13 . . . cord-010119-t1x9gknd 10662 1 It -PRON- PRP cord-010119-t1x9gknd 10662 2 was be VBD cord-010119-t1x9gknd 10662 3 important important JJ cord-010119-t1x9gknd 10662 4 for for IN cord-010119-t1x9gknd 10662 5 BBC BBC NNP cord-010119-t1x9gknd 10662 6 to to TO cord-010119-t1x9gknd 10662 7 reduce reduce VB cord-010119-t1x9gknd 10662 8 paperwork paperwork NN cord-010119-t1x9gknd 10662 9 and and CC cord-010119-t1x9gknd 10662 10 daily daily JJ cord-010119-t1x9gknd 10662 11 tasks task NNS cord-010119-t1x9gknd 10662 12 . . . cord-010119-t1x9gknd 10663 1 The the DT cord-010119-t1x9gknd 10663 2 CompoLab CompoLab NNP cord-010119-t1x9gknd 10663 3 eliminates eliminate VBZ cord-010119-t1x9gknd 10663 4 daily daily JJ cord-010119-t1x9gknd 10663 5 QC QC NNP cord-010119-t1x9gknd 10663 6 reducing reduce VBG cord-010119-t1x9gknd 10663 7 paperwork paperwork NN cord-010119-t1x9gknd 10663 8 , , , cord-010119-t1x9gknd 10663 9 time time NN cord-010119-t1x9gknd 10663 10 and and CC cord-010119-t1x9gknd 10663 11 improves improve VBZ cord-010119-t1x9gknd 10663 12 error error NN cord-010119-t1x9gknd 10663 13 management management NN cord-010119-t1x9gknd 10663 14 . . . cord-010119-t1x9gknd 10664 1 After after IN cord-010119-t1x9gknd 10664 2 converting convert VBG cord-010119-t1x9gknd 10664 3 to to IN cord-010119-t1x9gknd 10664 4 the the DT cord-010119-t1x9gknd 10664 5 new new JJ cord-010119-t1x9gknd 10664 6 technology technology NN cord-010119-t1x9gknd 10664 7 , , , cord-010119-t1x9gknd 10664 8 BBC BBC NNP cord-010119-t1x9gknd 10664 9 donor donor NN cord-010119-t1x9gknd 10664 10 deferral deferral NN cord-010119-t1x9gknd 10664 11 rates rate NNS cord-010119-t1x9gknd 10664 12 increased increase VBD cord-010119-t1x9gknd 10664 13 by by IN cord-010119-t1x9gknd 10664 14 approximately approximately RB cord-010119-t1x9gknd 10664 15 15 15 CD cord-010119-t1x9gknd 10664 16 % % NN cord-010119-t1x9gknd 10664 17 . . . cord-010119-t1x9gknd 10665 1 As as IN cord-010119-t1x9gknd 10665 2 a a DT cord-010119-t1x9gknd 10665 3 consequence consequence NN cord-010119-t1x9gknd 10665 4 to to IN cord-010119-t1x9gknd 10665 5 this this DT cord-010119-t1x9gknd 10665 6 increase increase NN cord-010119-t1x9gknd 10665 7 , , , cord-010119-t1x9gknd 10665 8 BBC BBC NNP cord-010119-t1x9gknd 10665 9 conducted conduct VBD cord-010119-t1x9gknd 10665 10 reminder reminder NN cord-010119-t1x9gknd 10665 11 training training NN cord-010119-t1x9gknd 10665 12 with with IN cord-010119-t1x9gknd 10665 13 BBC BBC NNP cord-010119-t1x9gknd 10665 14 staff staff NN cord-010119-t1x9gknd 10665 15 to to TO cord-010119-t1x9gknd 10665 16 ensure ensure VB cord-010119-t1x9gknd 10665 17 proper proper JJ cord-010119-t1x9gknd 10665 18 sampling sampling NN cord-010119-t1x9gknd 10665 19 technique technique NN cord-010119-t1x9gknd 10665 20 and and CC cord-010119-t1x9gknd 10665 21 higher high JJR cord-010119-t1x9gknd 10665 22 sample sample NN cord-010119-t1x9gknd 10665 23 quality quality NN cord-010119-t1x9gknd 10665 24 . . . cord-010119-t1x9gknd 10666 1 Over over IN cord-010119-t1x9gknd 10666 2 time time NN cord-010119-t1x9gknd 10666 3 , , , cord-010119-t1x9gknd 10666 4 BBC BBC NNP cord-010119-t1x9gknd 10666 5 deferral deferral NN cord-010119-t1x9gknd 10666 6 rates rate NNS cord-010119-t1x9gknd 10666 7 stabilized stabilize VBD cord-010119-t1x9gknd 10666 8 to to IN cord-010119-t1x9gknd 10666 9 4.59 4.59 CD cord-010119-t1x9gknd 10666 10 % % NN cord-010119-t1x9gknd 10666 11 in in IN cord-010119-t1x9gknd 10666 12 2014 2014 CD cord-010119-t1x9gknd 10666 13 and and CC cord-010119-t1x9gknd 10666 14 4.29 4.29 CD cord-010119-t1x9gknd 10666 15 % % NN cord-010119-t1x9gknd 10666 16 in in IN cord-010119-t1x9gknd 10666 17 2015 2015 CD cord-010119-t1x9gknd 10666 18 . . . cord-010119-t1x9gknd 10667 1 During during IN cord-010119-t1x9gknd 10667 2 this this DT cord-010119-t1x9gknd 10667 3 time time NN cord-010119-t1x9gknd 10667 4 period period NN cord-010119-t1x9gknd 10667 5 , , , cord-010119-t1x9gknd 10667 6 BBC BBC NNP cord-010119-t1x9gknd 10667 7 also also RB cord-010119-t1x9gknd 10667 8 successfully successfully RB cord-010119-t1x9gknd 10667 9 recruited recruit VBD cord-010119-t1x9gknd 10667 10 new new JJ cord-010119-t1x9gknd 10667 11 blood blood NN cord-010119-t1x9gknd 10667 12 donors donor NNS cord-010119-t1x9gknd 10667 13 to to IN cord-010119-t1x9gknd 10667 14 BBC BBC NNP cord-010119-t1x9gknd 10667 15 program program NN cord-010119-t1x9gknd 10667 16 , , , cord-010119-t1x9gknd 10667 17 which which WDT cord-010119-t1x9gknd 10667 18 may may MD cord-010119-t1x9gknd 10667 19 have have VB cord-010119-t1x9gknd 10667 20 contributed contribute VBN cord-010119-t1x9gknd 10667 21 to to IN cord-010119-t1x9gknd 10667 22 an an DT cord-010119-t1x9gknd 10667 23 increase increase NN cord-010119-t1x9gknd 10667 24 in in IN cord-010119-t1x9gknd 10667 25 deferral deferral NN cord-010119-t1x9gknd 10667 26 rates rate NNS cord-010119-t1x9gknd 10667 27 . . . cord-010119-t1x9gknd 10668 1 In in IN cord-010119-t1x9gknd 10668 2 2016 2016 CD cord-010119-t1x9gknd 10668 3 , , , cord-010119-t1x9gknd 10668 4 the the DT cord-010119-t1x9gknd 10668 5 deferral deferral NN cord-010119-t1x9gknd 10668 6 rate rate NN cord-010119-t1x9gknd 10668 7 increased increase VBD cord-010119-t1x9gknd 10668 8 again again RB cord-010119-t1x9gknd 10668 9 , , , cord-010119-t1x9gknd 10668 10 probably probably RB cord-010119-t1x9gknd 10668 11 due due JJ cord-010119-t1x9gknd 10668 12 in in IN cord-010119-t1x9gknd 10668 13 part part NN cord-010119-t1x9gknd 10668 14 to to IN cord-010119-t1x9gknd 10668 15 the the DT cord-010119-t1x9gknd 10668 16 FDA FDA NNP cord-010119-t1x9gknd 10668 17 Final Final NNP cord-010119-t1x9gknd 10668 18 Rule Rule NNP cord-010119-t1x9gknd 10668 19 " " '' cord-010119-t1x9gknd 10668 20 Requirements requirement NNS cord-010119-t1x9gknd 10668 21 for for IN cord-010119-t1x9gknd 10668 22 Blood blood NN cord-010119-t1x9gknd 10668 23 and and CC cord-010119-t1x9gknd 10668 24 Blood blood NN cord-010119-t1x9gknd 10668 25 Components component NNS cord-010119-t1x9gknd 10668 26 Intended intend VBN cord-010119-t1x9gknd 10668 27 for for IN cord-010119-t1x9gknd 10668 28 Transfusion Transfusion NNP cord-010119-t1x9gknd 10668 29 or or CC cord-010119-t1x9gknd 10668 30 for for IN cord-010119-t1x9gknd 10668 31 Further further JJ cord-010119-t1x9gknd 10668 32 Manufacturing manufacturing NN cord-010119-t1x9gknd 10668 33 Use Use NNP cord-010119-t1x9gknd 10668 34 " " '' cord-010119-t1x9gknd 10668 35 , , , cord-010119-t1x9gknd 10668 36 which which WDT cord-010119-t1x9gknd 10668 37 went go VBD cord-010119-t1x9gknd 10668 38 into into IN cord-010119-t1x9gknd 10668 39 effect effect NN cord-010119-t1x9gknd 10668 40 in in IN cord-010119-t1x9gknd 10668 41 May May NNP cord-010119-t1x9gknd 10668 42 2016 2016 CD cord-010119-t1x9gknd 10668 43 . . . cord-010119-t1x9gknd 10669 1 Conclusion conclusion NN cord-010119-t1x9gknd 10669 2 : : : cord-010119-t1x9gknd 10670 1 During during IN cord-010119-t1x9gknd 10670 2 the the DT cord-010119-t1x9gknd 10670 3 evaluation evaluation NN cord-010119-t1x9gknd 10670 4 for for IN cord-010119-t1x9gknd 10670 5 new new JJ cord-010119-t1x9gknd 10670 6 equipment equipment NN cord-010119-t1x9gknd 10670 7 , , , cord-010119-t1x9gknd 10670 8 BBC BBC NNP cord-010119-t1x9gknd 10670 9 learned learn VBD cord-010119-t1x9gknd 10670 10 that that IN cord-010119-t1x9gknd 10670 11 it -PRON- PRP cord-010119-t1x9gknd 10670 12 is be VBZ cord-010119-t1x9gknd 10670 13 critical critical JJ cord-010119-t1x9gknd 10670 14 to to TO cord-010119-t1x9gknd 10670 15 understand understand VB cord-010119-t1x9gknd 10670 16 the the DT cord-010119-t1x9gknd 10670 17 equipment equipment NN cord-010119-t1x9gknd 10670 18 's 's POS cord-010119-t1x9gknd 10670 19 life life NN cord-010119-t1x9gknd 10670 20 cycle cycle NN cord-010119-t1x9gknd 10670 21 and and CC cord-010119-t1x9gknd 10670 22 the the DT cord-010119-t1x9gknd 10670 23 effect effect NN cord-010119-t1x9gknd 10670 24 the the DT cord-010119-t1x9gknd 10670 25 equipment equipment NN cord-010119-t1x9gknd 10670 26 has have VBZ cord-010119-t1x9gknd 10670 27 on on IN cord-010119-t1x9gknd 10670 28 all all DT cord-010119-t1x9gknd 10670 29 aspects aspect NNS cord-010119-t1x9gknd 10670 30 of of IN cord-010119-t1x9gknd 10670 31 the the DT cord-010119-t1x9gknd 10670 32 business business NN cord-010119-t1x9gknd 10670 33 . . . cord-010119-t1x9gknd 10671 1 After after IN cord-010119-t1x9gknd 10671 2 comprehensive comprehensive JJ cord-010119-t1x9gknd 10671 3 evaluation evaluation NN cord-010119-t1x9gknd 10671 4 of of IN cord-010119-t1x9gknd 10671 5 multiple multiple JJ cord-010119-t1x9gknd 10671 6 donor donor NN cord-010119-t1x9gknd 10671 7 eligibility eligibility NN cord-010119-t1x9gknd 10671 8 screening screening NN cord-010119-t1x9gknd 10671 9 platforms platform NNS cord-010119-t1x9gknd 10671 10 , , , cord-010119-t1x9gknd 10671 11 the the DT cord-010119-t1x9gknd 10671 12 CompoLab CompoLab NNP cord-010119-t1x9gknd 10671 13 device device NN cord-010119-t1x9gknd 10671 14 was be VBD cord-010119-t1x9gknd 10671 15 selected select VBN cord-010119-t1x9gknd 10671 16 at at IN cord-010119-t1x9gknd 10671 17 BBC BBC NNP cord-010119-t1x9gknd 10671 18 facility facility NN cord-010119-t1x9gknd 10671 19 . . . cord-010119-t1x9gknd 10672 1 It -PRON- PRP cord-010119-t1x9gknd 10672 2 met meet VBD cord-010119-t1x9gknd 10672 3 the the DT cord-010119-t1x9gknd 10672 4 majority majority NN cord-010119-t1x9gknd 10672 5 of of IN cord-010119-t1x9gknd 10672 6 all all DT cord-010119-t1x9gknd 10672 7 aspects aspect NNS cord-010119-t1x9gknd 10672 8 of of IN cord-010119-t1x9gknd 10672 9 the the DT cord-010119-t1x9gknd 10672 10 project project NN cord-010119-t1x9gknd 10672 11 scope scope NN cord-010119-t1x9gknd 10672 12 and and CC cord-010119-t1x9gknd 10672 13 qualifying qualify VBG cord-010119-t1x9gknd 10672 14 criteria criterion NNS cord-010119-t1x9gknd 10672 15 . . . cord-010119-t1x9gknd 10673 1 BBC BBC NNP cord-010119-t1x9gknd 10673 2 also also RB cord-010119-t1x9gknd 10673 3 learned learn VBD cord-010119-t1x9gknd 10673 4 that that IN cord-010119-t1x9gknd 10673 5 continuous continuous JJ cord-010119-t1x9gknd 10673 6 refresher refresher NN cord-010119-t1x9gknd 10673 7 training training NN cord-010119-t1x9gknd 10673 8 of of IN cord-010119-t1x9gknd 10673 9 the the DT cord-010119-t1x9gknd 10673 10 staff staff NN cord-010119-t1x9gknd 10673 11 ensured ensure VBD cord-010119-t1x9gknd 10673 12 optimal optimal JJ cord-010119-t1x9gknd 10673 13 device device NN cord-010119-t1x9gknd 10673 14 performance performance NN cord-010119-t1x9gknd 10673 15 , , , cord-010119-t1x9gknd 10673 16 and and CC cord-010119-t1x9gknd 10673 17 how how WRB cord-010119-t1x9gknd 10673 18 external external JJ cord-010119-t1x9gknd 10673 19 factors factor NNS cord-010119-t1x9gknd 10673 20 such such JJ cord-010119-t1x9gknd 10673 21 as as IN cord-010119-t1x9gknd 10673 22 changes change NNS cord-010119-t1x9gknd 10673 23 to to IN cord-010119-t1x9gknd 10673 24 the the DT cord-010119-t1x9gknd 10673 25 regulatory regulatory JJ cord-010119-t1x9gknd 10673 26 environment environment NN cord-010119-t1x9gknd 10673 27 may may MD cord-010119-t1x9gknd 10673 28 impact impact VB cord-010119-t1x9gknd 10673 29 deferral deferral NN cord-010119-t1x9gknd 10673 30 rates rate NNS cord-010119-t1x9gknd 10673 31 . . . cord-010119-t1x9gknd 10674 1 Flowmetry Flowmetry NNP cord-010119-t1x9gknd 10674 2 on on IN cord-010119-t1x9gknd 10674 3 Platelet Platelet NNP cord-010119-t1x9gknd 10674 4 Apheresis Apheresis NNP cord-010119-t1x9gknd 10674 5 . . . cord-010119-t1x9gknd 10675 1 Tetsu Tetsu NNP cord-010119-t1x9gknd 10675 2 Yamamoto Yamamoto NNP cord-010119-t1x9gknd 10675 3 * * NFP cord-010119-t1x9gknd 10675 4 1 1 CD cord-010119-t1x9gknd 10675 5 , , , cord-010119-t1x9gknd 10675 6 Ayumi Ayumi NNP cord-010119-t1x9gknd 10675 7 Araki Araki NNP cord-010119-t1x9gknd 10675 8 1 1 CD cord-010119-t1x9gknd 10675 9 , , , cord-010119-t1x9gknd 10675 10 Hiromi Hiromi NNP cord-010119-t1x9gknd 10675 11 Sanyoshi Sanyoshi NNP cord-010119-t1x9gknd 10675 12 1 1 CD cord-010119-t1x9gknd 10675 13 , , , cord-010119-t1x9gknd 10675 14 Hiromi Hiromi NNP cord-010119-t1x9gknd 10675 15 Kanai Kanai NNP cord-010119-t1x9gknd 10675 16 1 1 CD cord-010119-t1x9gknd 10675 17 , , , cord-010119-t1x9gknd 10675 18 Hiroya Hiroya NNP cord-010119-t1x9gknd 10675 19 Kikuchi Kikuchi NNP cord-010119-t1x9gknd 10675 20 2 2 CD cord-010119-t1x9gknd 10675 21 , , , cord-010119-t1x9gknd 10675 22 Katsushi Katsushi NNP cord-010119-t1x9gknd 10675 23 Tsukada Tsukada NNP cord-010119-t1x9gknd 10675 24 2 2 CD cord-010119-t1x9gknd 10675 25 and and CC cord-010119-t1x9gknd 10675 26 Kazuhide Kazuhide NNP cord-010119-t1x9gknd 10675 27 Mure Mure NNP cord-010119-t1x9gknd 10675 28 2 2 CD cord-010119-t1x9gknd 10675 29 . . . cord-010119-t1x9gknd 10675 30 1 1 CD cord-010119-t1x9gknd 10675 31 Hokkaido Hokkaido NNP cord-010119-t1x9gknd 10675 32 Red Red NNP cord-010119-t1x9gknd 10675 33 Cross Cross NNP cord-010119-t1x9gknd 10675 34 Blood Blood NNP cord-010119-t1x9gknd 10675 35 Center Center NNP cord-010119-t1x9gknd 10675 36 , , , cord-010119-t1x9gknd 10675 37 2 2 CD cord-010119-t1x9gknd 10675 38 Japanese Japanese NNP cord-010119-t1x9gknd 10675 39 Red Red NNP cord-010119-t1x9gknd 10675 40 Cross Cross NNP cord-010119-t1x9gknd 10675 41 Hokkaido Hokkaido NNP cord-010119-t1x9gknd 10675 42 Blood Blood NNP cord-010119-t1x9gknd 10675 43 Center Center NNP cord-010119-t1x9gknd 10675 44 Background Background NNP cord-010119-t1x9gknd 10675 45 / / SYM cord-010119-t1x9gknd 10675 46 Case Case NNP cord-010119-t1x9gknd 10675 47 Studies Studies NNPS cord-010119-t1x9gknd 10675 48 : : : cord-010119-t1x9gknd 10675 49 Vasovagal vasovagal JJ cord-010119-t1x9gknd 10675 50 reaction reaction NN cord-010119-t1x9gknd 10675 51 ( ( -LRB- cord-010119-t1x9gknd 10675 52 VVR vvr NN cord-010119-t1x9gknd 10675 53 ) ) -RRB- cord-010119-t1x9gknd 10675 54 is be VBZ cord-010119-t1x9gknd 10675 55 known know VBN cord-010119-t1x9gknd 10675 56 to to TO cord-010119-t1x9gknd 10675 57 be be VB cord-010119-t1x9gknd 10675 58 the the DT cord-010119-t1x9gknd 10675 59 most most RBS cord-010119-t1x9gknd 10675 60 common common JJ cord-010119-t1x9gknd 10675 61 adverse adverse JJ cord-010119-t1x9gknd 10675 62 reaction reaction NN cord-010119-t1x9gknd 10675 63 to to IN cord-010119-t1x9gknd 10675 64 blood blood NN cord-010119-t1x9gknd 10675 65 collection collection NN cord-010119-t1x9gknd 10675 66 , , , cord-010119-t1x9gknd 10675 67 but but CC cord-010119-t1x9gknd 10675 68 effective effective JJ cord-010119-t1x9gknd 10675 69 measures measure NNS cord-010119-t1x9gknd 10675 70 for for IN cord-010119-t1x9gknd 10675 71 preventing prevent VBG cord-010119-t1x9gknd 10675 72 VVR vvr NN cord-010119-t1x9gknd 10675 73 have have VBP cord-010119-t1x9gknd 10675 74 not not RB cord-010119-t1x9gknd 10675 75 yet yet RB cord-010119-t1x9gknd 10675 76 been be VBN cord-010119-t1x9gknd 10675 77 developed develop VBN cord-010119-t1x9gknd 10675 78 . . . cord-010119-t1x9gknd 10676 1 Effective effective JJ cord-010119-t1x9gknd 10676 2 timing timing NN cord-010119-t1x9gknd 10676 3 of of IN cord-010119-t1x9gknd 10676 4 interventions intervention NNS cord-010119-t1x9gknd 10676 5 during during IN cord-010119-t1x9gknd 10676 6 apheresis apheresis NN cord-010119-t1x9gknd 10676 7 donations donation NNS cord-010119-t1x9gknd 10676 8 in in IN cord-010119-t1x9gknd 10676 9 particular particular JJ cord-010119-t1x9gknd 10676 10 should should MD cord-010119-t1x9gknd 10676 11 hold hold VB cord-010119-t1x9gknd 10676 12 the the DT cord-010119-t1x9gknd 10676 13 key key NN cord-010119-t1x9gknd 10676 14 to to IN cord-010119-t1x9gknd 10676 15 predicting predict VBG cord-010119-t1x9gknd 10676 16 VVR vvr NN cord-010119-t1x9gknd 10676 17 , , , cord-010119-t1x9gknd 10676 18 but but CC cord-010119-t1x9gknd 10676 19 no no DT cord-010119-t1x9gknd 10676 20 research research NN cord-010119-t1x9gknd 10676 21 has have VBZ cord-010119-t1x9gknd 10676 22 been be VBN cord-010119-t1x9gknd 10676 23 done do VBN cord-010119-t1x9gknd 10676 24 on on IN cord-010119-t1x9gknd 10676 25 the the DT cord-010119-t1x9gknd 10676 26 topic topic NN cord-010119-t1x9gknd 10676 27 . . . cord-010119-t1x9gknd 10677 1 Study Study NNP cord-010119-t1x9gknd 10677 2 Design Design NNP cord-010119-t1x9gknd 10677 3 / / SYM cord-010119-t1x9gknd 10677 4 Methods method NNS cord-010119-t1x9gknd 10677 5 : : : cord-010119-t1x9gknd 10677 6 This this DT cord-010119-t1x9gknd 10677 7 study study NN cord-010119-t1x9gknd 10677 8 investigated investigate VBD cord-010119-t1x9gknd 10677 9 the the DT cord-010119-t1x9gknd 10677 10 potential potential NN cord-010119-t1x9gknd 10677 11 to to TO cord-010119-t1x9gknd 10677 12 predict predict VB cord-010119-t1x9gknd 10677 13 VVR vvr NN cord-010119-t1x9gknd 10677 14 from from IN cord-010119-t1x9gknd 10677 15 fluctuations fluctuation NNS cord-010119-t1x9gknd 10677 16 in in IN cord-010119-t1x9gknd 10677 17 peripheral peripheral JJ cord-010119-t1x9gknd 10677 18 blood blood NN cord-010119-t1x9gknd 10677 19 flow flow NN cord-010119-t1x9gknd 10677 20 measured measure VBN cord-010119-t1x9gknd 10677 21 by by IN cord-010119-t1x9gknd 10677 22 laser laser NN cord-010119-t1x9gknd 10677 23 Doppler Doppler NNP cord-010119-t1x9gknd 10677 24 flowmetry flowmetry NN cord-010119-t1x9gknd 10677 25 in in IN cord-010119-t1x9gknd 10677 26 platelet platelet NN cord-010119-t1x9gknd 10677 27 apheresis apheresis NN cord-010119-t1x9gknd 10677 28 donors donor NNS cord-010119-t1x9gknd 10677 29 , , , cord-010119-t1x9gknd 10677 30 a a DT cord-010119-t1x9gknd 10677 31 population population NN cord-010119-t1x9gknd 10677 32 highly highly RB cord-010119-t1x9gknd 10677 33 likely likely JJ cord-010119-t1x9gknd 10677 34 to to TO cord-010119-t1x9gknd 10677 35 experience experience VB cord-010119-t1x9gknd 10677 36 VVR vvr NN cord-010119-t1x9gknd 10677 37 . . . cord-010119-t1x9gknd 10678 1 Data datum NNS cord-010119-t1x9gknd 10678 2 were be VBD cord-010119-t1x9gknd 10678 3 collected collect VBN cord-010119-t1x9gknd 10678 4 from from IN cord-010119-t1x9gknd 10678 5 354 354 CD cord-010119-t1x9gknd 10678 6 individuals individual NNS cord-010119-t1x9gknd 10678 7 who who WP cord-010119-t1x9gknd 10678 8 donated donate VBD cord-010119-t1x9gknd 10678 9 platelets platelet NNS cord-010119-t1x9gknd 10678 10 during during IN cord-010119-t1x9gknd 10678 11 the the DT cord-010119-t1x9gknd 10678 12 6-month 6-month CD cord-010119-t1x9gknd 10678 13 period period NN cord-010119-t1x9gknd 10678 14 between between IN cord-010119-t1x9gknd 10678 15 February February NNP cord-010119-t1x9gknd 10678 16 and and CC cord-010119-t1x9gknd 10678 17 August August NNP cord-010119-t1x9gknd 10678 18 2015 2015 CD cord-010119-t1x9gknd 10678 19 , , , cord-010119-t1x9gknd 10678 20 and and CC cord-010119-t1x9gknd 10678 21 data datum NNS cord-010119-t1x9gknd 10678 22 from from IN cord-010119-t1x9gknd 10678 23 the the DT cord-010119-t1x9gknd 10678 24 30 30 CD cord-010119-t1x9gknd 10678 25 donors donor NNS cord-010119-t1x9gknd 10678 26 who who WP cord-010119-t1x9gknd 10678 27 experienced experience VBD cord-010119-t1x9gknd 10678 28 VVR VVR NNP cord-010119-t1x9gknd 10678 29 were be VBD cord-010119-t1x9gknd 10678 30 analyzed analyze VBN cord-010119-t1x9gknd 10678 31 . . . cord-010119-t1x9gknd 10679 1 To to TO cord-010119-t1x9gknd 10679 2 calculate calculate VB cord-010119-t1x9gknd 10679 3 the the DT cord-010119-t1x9gknd 10679 4 level level NN cord-010119-t1x9gknd 10679 5 for for IN cord-010119-t1x9gknd 10679 6 issuing issue VBG cord-010119-t1x9gknd 10679 7 VVR vvr NN cord-010119-t1x9gknd 10679 8 alert alert NN cord-010119-t1x9gknd 10679 9 , , , cord-010119-t1x9gknd 10679 10 the the DT cord-010119-t1x9gknd 10679 11 percent percent NN cord-010119-t1x9gknd 10679 12 decrease decrease NN cord-010119-t1x9gknd 10679 13 in in IN cord-010119-t1x9gknd 10679 14 blood blood NN cord-010119-t1x9gknd 10679 15 flow flow NN cord-010119-t1x9gknd 10679 16 ( ( -LRB- cord-010119-t1x9gknd 10679 17 DBF DBF NNP cord-010119-t1x9gknd 10679 18 ) ) -RRB- cord-010119-t1x9gknd 10679 19 and and CC cord-010119-t1x9gknd 10679 20 the the DT cord-010119-t1x9gknd 10679 21 percent percent NN cord-010119-t1x9gknd 10679 22 decrease decrease NN cord-010119-t1x9gknd 10679 23 in in IN cord-010119-t1x9gknd 10679 24 heart heart NN cord-010119-t1x9gknd 10679 25 rate rate NN cord-010119-t1x9gknd 10679 26 ( ( -LRB- cord-010119-t1x9gknd 10679 27 DHR DHR NNP cord-010119-t1x9gknd 10679 28 ) ) -RRB- cord-010119-t1x9gknd 10679 29 were be VBD cord-010119-t1x9gknd 10679 30 calculated calculate VBN cord-010119-t1x9gknd 10679 31 , , , cord-010119-t1x9gknd 10679 32 the the DT cord-010119-t1x9gknd 10679 33 time time NN cord-010119-t1x9gknd 10679 34 from from IN cord-010119-t1x9gknd 10679 35 alert alert NN cord-010119-t1x9gknd 10679 36 to to IN cord-010119-t1x9gknd 10679 37 VVR VVR NNP cord-010119-t1x9gknd 10679 38 was be VBD cord-010119-t1x9gknd 10679 39 estimated estimate VBN cord-010119-t1x9gknd 10679 40 for for IN cord-010119-t1x9gknd 10679 41 three three CD cord-010119-t1x9gknd 10679 42 DBF DBF NNP cord-010119-t1x9gknd 10679 43 levels level NNS cord-010119-t1x9gknd 10679 44 , , , cord-010119-t1x9gknd 10679 45 and and CC cord-010119-t1x9gknd 10679 46 the the DT cord-010119-t1x9gknd 10679 47 detection detection NN cord-010119-t1x9gknd 10679 48 performance performance NN cord-010119-t1x9gknd 10679 49 of of IN cord-010119-t1x9gknd 10679 50 each each DT cord-010119-t1x9gknd 10679 51 alert alert JJ cord-010119-t1x9gknd 10679 52 level level NN cord-010119-t1x9gknd 10679 53 was be VBD cord-010119-t1x9gknd 10679 54 calculated calculate VBN cord-010119-t1x9gknd 10679 55 . . . cord-010119-t1x9gknd 10680 1 Results result NNS cord-010119-t1x9gknd 10680 2 / / SYM cord-010119-t1x9gknd 10680 3 Findings finding NNS cord-010119-t1x9gknd 10680 4 : : : cord-010119-t1x9gknd 10680 5 Eight eight CD cord-010119-t1x9gknd 10680 6 of of IN cord-010119-t1x9gknd 10680 7 the the DT cord-010119-t1x9gknd 10680 8 156 156 CD cord-010119-t1x9gknd 10680 9 men man NNS cord-010119-t1x9gknd 10680 10 ( ( -LRB- cord-010119-t1x9gknd 10680 11 5.1 5.1 CD cord-010119-t1x9gknd 10680 12 % % NN cord-010119-t1x9gknd 10680 13 ) ) -RRB- cord-010119-t1x9gknd 10680 14 and and CC cord-010119-t1x9gknd 10680 15 22 22 CD cord-010119-t1x9gknd 10680 16 of of IN cord-010119-t1x9gknd 10680 17 the the DT cord-010119-t1x9gknd 10680 18 198 198 CD cord-010119-t1x9gknd 10680 19 women woman NNS cord-010119-t1x9gknd 10680 20 ( ( -LRB- cord-010119-t1x9gknd 10680 21 11.1 11.1 CD cord-010119-t1x9gknd 10680 22 % % NN cord-010119-t1x9gknd 10680 23 ) ) -RRB- cord-010119-t1x9gknd 10680 24 experienced experience VBD cord-010119-t1x9gknd 10680 25 VVR vvr NN cord-010119-t1x9gknd 10680 26 . . . cord-010119-t1x9gknd 10681 1 One one CD cord-010119-t1x9gknd 10681 2 donor donor NN cord-010119-t1x9gknd 10681 3 did do VBD cord-010119-t1x9gknd 10681 4 not not RB cord-010119-t1x9gknd 10681 5 experience experience VB cord-010119-t1x9gknd 10681 6 VVR vvr NN cord-010119-t1x9gknd 10681 7 during during IN cord-010119-t1x9gknd 10681 8 blood blood NN cord-010119-t1x9gknd 10681 9 collection collection NN cord-010119-t1x9gknd 10681 10 , , , cord-010119-t1x9gknd 10681 11 but but CC cord-010119-t1x9gknd 10681 12 had have VBD cord-010119-t1x9gknd 10681 13 a a DT cord-010119-t1x9gknd 10681 14 delayed delay VBN cord-010119-t1x9gknd 10681 15 reaction reaction NN cord-010119-t1x9gknd 10681 16 while while IN cord-010119-t1x9gknd 10681 17 resting rest VBG cord-010119-t1x9gknd 10681 18 afterward afterward RB cord-010119-t1x9gknd 10681 19 . . . cord-010119-t1x9gknd 10682 1 Mean mean JJ cord-010119-t1x9gknd 10682 2 maximum maximum JJ cord-010119-t1x9gknd 10682 3 DBF DBF NNP cord-010119-t1x9gknd 10682 4 in in IN cord-010119-t1x9gknd 10682 5 the the DT cord-010119-t1x9gknd 10682 6 30 30 CD cord-010119-t1x9gknd 10682 7 donors donor NNS cord-010119-t1x9gknd 10682 8 in in IN cord-010119-t1x9gknd 10682 9 the the DT cord-010119-t1x9gknd 10682 10 VVR VVR NNP cord-010119-t1x9gknd 10682 11 group group NN cord-010119-t1x9gknd 10682 12 was be VBD cord-010119-t1x9gknd 10682 13 64.7 64.7 CD cord-010119-t1x9gknd 10682 14 6 6 CD cord-010119-t1x9gknd 10682 15 13.7 13.7 CD cord-010119-t1x9gknd 10682 16 % % NN cord-010119-t1x9gknd 10682 17 , , , cord-010119-t1x9gknd 10682 18 which which WDT cord-010119-t1x9gknd 10682 19 was be VBD cord-010119-t1x9gknd 10682 20 significantly significantly RB cord-010119-t1x9gknd 10682 21 higher high JJR cord-010119-t1x9gknd 10682 22 than than IN cord-010119-t1x9gknd 10682 23 the the DT cord-010119-t1x9gknd 10682 24 25.6 25.6 CD cord-010119-t1x9gknd 10682 25 6 6 CD cord-010119-t1x9gknd 10682 26 11.7 11.7 CD cord-010119-t1x9gknd 10682 27 % % NN cord-010119-t1x9gknd 10682 28 in in IN cord-010119-t1x9gknd 10682 29 the the DT cord-010119-t1x9gknd 10682 30 non non JJ cord-010119-t1x9gknd 10682 31 - - JJ cord-010119-t1x9gknd 10682 32 VVR vvr JJ cord-010119-t1x9gknd 10682 33 group group NN cord-010119-t1x9gknd 10682 34 . . . cord-010119-t1x9gknd 10683 1 At at IN cord-010119-t1x9gknd 10683 2 a a DT cord-010119-t1x9gknd 10683 3 maximum maximum JJ cord-010119-t1x9gknd 10683 4 DBF DBF NNP cord-010119-t1x9gknd 10683 5 threshold threshold NN cord-010119-t1x9gknd 10683 6 of of IN cord-010119-t1x9gknd 10683 7 45 45 CD cord-010119-t1x9gknd 10683 8 % % NN cord-010119-t1x9gknd 10683 9 , , , cord-010119-t1x9gknd 10683 10 sensitivity sensitivity NN cord-010119-t1x9gknd 10683 11 for for IN cord-010119-t1x9gknd 10683 12 discriminating discriminate VBG cord-010119-t1x9gknd 10683 13 between between IN cord-010119-t1x9gknd 10683 14 VVR vvr NN cord-010119-t1x9gknd 10683 15 and and CC cord-010119-t1x9gknd 10683 16 non non JJ cord-010119-t1x9gknd 10683 17 - - JJ cord-010119-t1x9gknd 10683 18 VVR vvr JJ cord-010119-t1x9gknd 10683 19 donors donor NNS cord-010119-t1x9gknd 10683 20 was be VBD cord-010119-t1x9gknd 10683 21 93.3 93.3 CD cord-010119-t1x9gknd 10683 22 % % NN cord-010119-t1x9gknd 10683 23 and and CC cord-010119-t1x9gknd 10683 24 accuracy accuracy NN cord-010119-t1x9gknd 10683 25 was be VBD cord-010119-t1x9gknd 10683 26 94.4 94.4 CD cord-010119-t1x9gknd 10683 27 % % NN cord-010119-t1x9gknd 10683 28 . . . cord-010119-t1x9gknd 10684 1 When when WRB cord-010119-t1x9gknd 10684 2 45 45 CD cord-010119-t1x9gknd 10684 3 % % NN cord-010119-t1x9gknd 10684 4 DBF DBF NNP cord-010119-t1x9gknd 10684 5 was be VBD cord-010119-t1x9gknd 10684 6 used use VBN cord-010119-t1x9gknd 10684 7 as as IN cord-010119-t1x9gknd 10684 8 the the DT cord-010119-t1x9gknd 10684 9 alert alert JJ cord-010119-t1x9gknd 10684 10 level level NN cord-010119-t1x9gknd 10684 11 , , , cord-010119-t1x9gknd 10684 12 alerts alert NNS cord-010119-t1x9gknd 10684 13 were be VBD cord-010119-t1x9gknd 10684 14 issued issue VBN cord-010119-t1x9gknd 10684 15 for for IN cord-010119-t1x9gknd 10684 16 44 44 CD cord-010119-t1x9gknd 10684 17 donors donor NNS cord-010119-t1x9gknd 10684 18 , , , cord-010119-t1x9gknd 10684 19 including include VBG cord-010119-t1x9gknd 10684 20 25 25 CD cord-010119-t1x9gknd 10684 21 in in IN cord-010119-t1x9gknd 10684 22 the the DT cord-010119-t1x9gknd 10684 23 VVR VVR NNP cord-010119-t1x9gknd 10684 24 group group NN cord-010119-t1x9gknd 10684 25 . . . cord-010119-t1x9gknd 10685 1 Therefore therefore RB cord-010119-t1x9gknd 10685 2 sensitivity sensitivity NN cord-010119-t1x9gknd 10685 3 for for IN cord-010119-t1x9gknd 10685 4 predicting predict VBG cord-010119-t1x9gknd 10685 5 VVR vvr NN cord-010119-t1x9gknd 10685 6 was be VBD cord-010119-t1x9gknd 10685 7 83.3 83.3 CD cord-010119-t1x9gknd 10685 8 % % NN cord-010119-t1x9gknd 10685 9 and and CC cord-010119-t1x9gknd 10685 10 specificity specificity NN cord-010119-t1x9gknd 10685 11 was be VBD cord-010119-t1x9gknd 10685 12 94.1 94.1 CD cord-010119-t1x9gknd 10685 13 % % NN cord-010119-t1x9gknd 10685 14 . . . cord-010119-t1x9gknd 10686 1 Mean mean JJ cord-010119-t1x9gknd 10686 2 time time NN cord-010119-t1x9gknd 10686 3 from from IN cord-010119-t1x9gknd 10686 4 alert alert NN cord-010119-t1x9gknd 10686 5 to to IN cord-010119-t1x9gknd 10686 6 diagnosis diagnosis NN cord-010119-t1x9gknd 10686 7 in in IN cord-010119-t1x9gknd 10686 8 the the DT cord-010119-t1x9gknd 10686 9 VVR VVR NNP cord-010119-t1x9gknd 10686 10 group group NN cord-010119-t1x9gknd 10686 11 was be VBD cord-010119-t1x9gknd 10686 12 4.03 4.03 CD cord-010119-t1x9gknd 10686 13 6 6 CD cord-010119-t1x9gknd 10686 14 4.35 4.35 CD cord-010119-t1x9gknd 10686 15 minutes minute NNS cord-010119-t1x9gknd 10686 16 , , , cord-010119-t1x9gknd 10686 17 and and CC cord-010119-t1x9gknd 10686 18 accuracy accuracy NN cord-010119-t1x9gknd 10686 19 of of IN cord-010119-t1x9gknd 10686 20 the the DT cord-010119-t1x9gknd 10686 21 alert alert NN cord-010119-t1x9gknd 10686 22 was be VBD cord-010119-t1x9gknd 10686 23 56.8 56.8 CD cord-010119-t1x9gknd 10686 24 % % NN cord-010119-t1x9gknd 10686 25 . . . cord-010119-t1x9gknd 10687 1 Some some DT cord-010119-t1x9gknd 10687 2 of of IN cord-010119-t1x9gknd 10687 3 the the DT cord-010119-t1x9gknd 10687 4 VVR vvr NN cord-010119-t1x9gknd 10687 5 could could MD cord-010119-t1x9gknd 10687 6 not not RB cord-010119-t1x9gknd 10687 7 be be VB cord-010119-t1x9gknd 10687 8 predicted predict VBN cord-010119-t1x9gknd 10687 9 even even RB cord-010119-t1x9gknd 10687 10 the the DT cord-010119-t1x9gknd 10687 11 value value NN cord-010119-t1x9gknd 10687 12 of of IN cord-010119-t1x9gknd 10687 13 maximum maximum JJ cord-010119-t1x9gknd 10687 14 DBF DBF NNP cord-010119-t1x9gknd 10687 15 exceeded exceed VBD cord-010119-t1x9gknd 10687 16 45 45 CD cord-010119-t1x9gknd 10687 17 % % NN cord-010119-t1x9gknd 10687 18 . . . cord-010119-t1x9gknd 10688 1 The the DT cord-010119-t1x9gknd 10688 2 reason reason NN cord-010119-t1x9gknd 10688 3 was be VBD cord-010119-t1x9gknd 10688 4 supposed suppose VBN cord-010119-t1x9gknd 10688 5 to to TO cord-010119-t1x9gknd 10688 6 be be VB cord-010119-t1x9gknd 10688 7 the the DT cord-010119-t1x9gknd 10688 8 difference difference NN cord-010119-t1x9gknd 10688 9 of of IN cord-010119-t1x9gknd 10688 10 donor donor NN cord-010119-t1x9gknd 10688 11 susceptibility susceptibility NN cord-010119-t1x9gknd 10688 12 on on IN cord-010119-t1x9gknd 10688 13 DBF DBF NNP cord-010119-t1x9gknd 10688 14 . . . cord-010119-t1x9gknd 10689 1 Conclusion conclusion NN cord-010119-t1x9gknd 10689 2 : : : cord-010119-t1x9gknd 10690 1 We -PRON- PRP cord-010119-t1x9gknd 10690 2 investigated investigate VBD cord-010119-t1x9gknd 10690 3 whether whether IN cord-010119-t1x9gknd 10690 4 VVR vvr NN cord-010119-t1x9gknd 10690 5 in in IN cord-010119-t1x9gknd 10690 6 platelet platelet NN cord-010119-t1x9gknd 10690 7 apheresis apheresis NN cord-010119-t1x9gknd 10690 8 donors donor NNS cord-010119-t1x9gknd 10690 9 can can MD cord-010119-t1x9gknd 10690 10 be be VB cord-010119-t1x9gknd 10690 11 prevented prevent VBN cord-010119-t1x9gknd 10690 12 by by IN cord-010119-t1x9gknd 10690 13 prediction prediction NN cord-010119-t1x9gknd 10690 14 and and CC cord-010119-t1x9gknd 10690 15 found find VBD cord-010119-t1x9gknd 10690 16 that that IN cord-010119-t1x9gknd 10690 17 it -PRON- PRP cord-010119-t1x9gknd 10690 18 is be VBZ cord-010119-t1x9gknd 10690 19 possible possible JJ cord-010119-t1x9gknd 10690 20 to to TO cord-010119-t1x9gknd 10690 21 predict predict VB cord-010119-t1x9gknd 10690 22 VVR vvr NN cord-010119-t1x9gknd 10690 23 early early RB cord-010119-t1x9gknd 10690 24 enough enough RB cord-010119-t1x9gknd 10690 25 before before IN cord-010119-t1x9gknd 10690 26 onset onset NN cord-010119-t1x9gknd 10690 27 to to TO cord-010119-t1x9gknd 10690 28 intervene intervene VB cord-010119-t1x9gknd 10690 29 by by IN cord-010119-t1x9gknd 10690 30 monitoring monitor VBG cord-010119-t1x9gknd 10690 31 DBF DBF NNP cord-010119-t1x9gknd 10690 32 in in IN cord-010119-t1x9gknd 10690 33 real real JJ cord-010119-t1x9gknd 10690 34 time time NN cord-010119-t1x9gknd 10690 35 during during IN cord-010119-t1x9gknd 10690 36 blood blood NN cord-010119-t1x9gknd 10690 37 collection collection NN cord-010119-t1x9gknd 10690 38 using use VBG cord-010119-t1x9gknd 10690 39 laser laser NN cord-010119-t1x9gknd 10690 40 Doppler Doppler NNP cord-010119-t1x9gknd 10690 41 flowmetry flowmetry NN cord-010119-t1x9gknd 10690 42 . . . cord-010119-t1x9gknd 10691 1 Future future JJ cord-010119-t1x9gknd 10691 2 research research NN cord-010119-t1x9gknd 10691 3 must must MD cord-010119-t1x9gknd 10691 4 also also RB cord-010119-t1x9gknd 10691 5 investigate investigate VB cord-010119-t1x9gknd 10691 6 whether whether IN cord-010119-t1x9gknd 10691 7 the the DT cord-010119-t1x9gknd 10691 8 incidence incidence NN cord-010119-t1x9gknd 10691 9 of of IN cord-010119-t1x9gknd 10691 10 VVR VVR NNP cord-010119-t1x9gknd 10691 11 can can MD cord-010119-t1x9gknd 10691 12 actually actually RB cord-010119-t1x9gknd 10691 13 be be VB cord-010119-t1x9gknd 10691 14 reduced reduce VBN cord-010119-t1x9gknd 10691 15 by by IN cord-010119-t1x9gknd 10691 16 interventions intervention NNS cord-010119-t1x9gknd 10691 17 such such JJ cord-010119-t1x9gknd 10691 18 as as IN cord-010119-t1x9gknd 10691 19 adjusting adjust VBG cord-010119-t1x9gknd 10691 20 extracorporeal extracorporeal JJ cord-010119-t1x9gknd 10691 21 circulation circulation NN cord-010119-t1x9gknd 10691 22 . . . cord-010119-t1x9gknd 10692 1 The the DT cord-010119-t1x9gknd 10692 2 Risks risk NNS cord-010119-t1x9gknd 10692 3 of of IN cord-010119-t1x9gknd 10692 4 Alloimmunization Alloimmunization NNP cord-010119-t1x9gknd 10692 5 in in IN cord-010119-t1x9gknd 10692 6 Sickle Sickle NNP cord-010119-t1x9gknd 10692 7 Cell Cell NNP cord-010119-t1x9gknd 10692 8 Patients patient NNS cord-010119-t1x9gknd 10692 9 Using use VBG cord-010119-t1x9gknd 10692 10 C C NNP cord-010119-t1x9gknd 10692 11 , , , cord-010119-t1x9gknd 10692 12 E E NNP cord-010119-t1x9gknd 10692 13 , , , cord-010119-t1x9gknd 10692 14 K K NNP cord-010119-t1x9gknd 10692 15 Negative negative JJ cord-010119-t1x9gknd 10692 16 Blood blood NN cord-010119-t1x9gknd 10692 17 : : : cord-010119-t1x9gknd 10692 18 Experience experience NN cord-010119-t1x9gknd 10692 19 of of IN cord-010119-t1x9gknd 10692 20 a a DT cord-010119-t1x9gknd 10692 21 Hospital Hospital NNP cord-010119-t1x9gknd 10692 22 Apheresis Apheresis NNP cord-010119-t1x9gknd 10692 23 and and CC cord-010119-t1x9gknd 10692 24 Transfusion Transfusion NNP cord-010119-t1x9gknd 10692 25 Service Service NNP cord-010119-t1x9gknd 10692 26 Grace Grace NNP cord-010119-t1x9gknd 10692 27 Banez Banez NNP cord-010119-t1x9gknd 10692 28 Sese Sese NNP cord-010119-t1x9gknd 10692 29 * * NFP cord-010119-t1x9gknd 10692 30 1,2 1,2 CD cord-010119-t1x9gknd 10692 31 , , , cord-010119-t1x9gknd 10692 32 Salam Salam NNP cord-010119-t1x9gknd 10692 33 Abdus Abdus NNP cord-010119-t1x9gknd 10692 34 3 3 CD cord-010119-t1x9gknd 10692 35 and and CC cord-010119-t1x9gknd 10692 36 Shabrina Shabrina NNP cord-010119-t1x9gknd 10692 37 Shah Shah NNP cord-010119-t1x9gknd 10692 38 3 3 CD cord-010119-t1x9gknd 10692 39 . . . cord-010119-t1x9gknd 10693 1 1 1 LS cord-010119-t1x9gknd 10694 1 Inova Inova NNP cord-010119-t1x9gknd 10694 2 Blood Blood NNP cord-010119-t1x9gknd 10694 3 Donor Donor NNP cord-010119-t1x9gknd 10694 4 Services Services NNPS cord-010119-t1x9gknd 10694 5 , , , cord-010119-t1x9gknd 10694 6 2 2 CD cord-010119-t1x9gknd 10694 7 Inova Inova NNP cord-010119-t1x9gknd 10694 8 Fairfax Fairfax NNP cord-010119-t1x9gknd 10694 9 Medical Medical NNP cord-010119-t1x9gknd 10694 10 Campus Campus NNP cord-010119-t1x9gknd 10694 11 , , , cord-010119-t1x9gknd 10694 12 3 3 CD cord-010119-t1x9gknd 10694 13 Inova Inova NNP cord-010119-t1x9gknd 10694 14 Fairfax Fairfax NNP cord-010119-t1x9gknd 10694 15 Medical Medical NNP cord-010119-t1x9gknd 10694 16 Campus Campus NNP cord-010119-t1x9gknd 10694 17 Transfusion Transfusion NNP cord-010119-t1x9gknd 10694 18 Services Services NNPS cord-010119-t1x9gknd 10694 19 Background Background NNP cord-010119-t1x9gknd 10694 20 / / SYM cord-010119-t1x9gknd 10694 21 Case Case NNP cord-010119-t1x9gknd 10694 22 Studies Studies NNPS cord-010119-t1x9gknd 10694 23 : : : cord-010119-t1x9gknd 10695 1 Red red JJ cord-010119-t1x9gknd 10695 2 blood blood NN cord-010119-t1x9gknd 10695 3 cell cell NN cord-010119-t1x9gknd 10695 4 ( ( -LRB- cord-010119-t1x9gknd 10695 5 RBC RBC NNP cord-010119-t1x9gknd 10695 6 ) ) -RRB- cord-010119-t1x9gknd 10695 7 transfusion transfusion NN cord-010119-t1x9gknd 10695 8 is be VBZ cord-010119-t1x9gknd 10695 9 often often RB cord-010119-t1x9gknd 10695 10 a a DT cord-010119-t1x9gknd 10695 11 lifesaving lifesaving JJ cord-010119-t1x9gknd 10695 12 measure measure NN cord-010119-t1x9gknd 10695 13 for for IN cord-010119-t1x9gknd 10695 14 patients patient NNS cord-010119-t1x9gknd 10695 15 with with IN cord-010119-t1x9gknd 10695 16 sickle sickle NN cord-010119-t1x9gknd 10695 17 cell cell NN cord-010119-t1x9gknd 10695 18 disease disease NN cord-010119-t1x9gknd 10695 19 ( ( -LRB- cord-010119-t1x9gknd 10695 20 SCD SCD NNP cord-010119-t1x9gknd 10695 21 ) ) -RRB- cord-010119-t1x9gknd 10695 22 . . . cord-010119-t1x9gknd 10696 1 It -PRON- PRP cord-010119-t1x9gknd 10696 2 is be VBZ cord-010119-t1x9gknd 10696 3 critical critical JJ cord-010119-t1x9gknd 10696 4 in in IN cord-010119-t1x9gknd 10696 5 the the DT cord-010119-t1x9gknd 10696 6 management management NN cord-010119-t1x9gknd 10696 7 of of IN cord-010119-t1x9gknd 10696 8 SCD SCD NNP cord-010119-t1x9gknd 10696 9 complications complication NNS cord-010119-t1x9gknd 10696 10 such such JJ cord-010119-t1x9gknd 10696 11 as as IN cord-010119-t1x9gknd 10696 12 splenic splenic JJ cord-010119-t1x9gknd 10696 13 sequestration sequestration NN cord-010119-t1x9gknd 10696 14 , , , cord-010119-t1x9gknd 10696 15 stroke stroke NN cord-010119-t1x9gknd 10696 16 , , , cord-010119-t1x9gknd 10696 17 priapism priapism NN cord-010119-t1x9gknd 10696 18 , , , cord-010119-t1x9gknd 10696 19 iron iron NN cord-010119-t1x9gknd 10696 20 overload overload NN cord-010119-t1x9gknd 10696 21 and and CC cord-010119-t1x9gknd 10696 22 acute acute JJ cord-010119-t1x9gknd 10696 23 chest chest NN cord-010119-t1x9gknd 10696 24 syndrome syndrome NN cord-010119-t1x9gknd 10696 25 . . . cord-010119-t1x9gknd 10697 1 A a DT cord-010119-t1x9gknd 10697 2 wellrecognized wellrecognized JJ cord-010119-t1x9gknd 10697 3 complication complication NN cord-010119-t1x9gknd 10697 4 of of IN cord-010119-t1x9gknd 10697 5 chronic chronic JJ cord-010119-t1x9gknd 10697 6 transfusion transfusion NN cord-010119-t1x9gknd 10697 7 in in IN cord-010119-t1x9gknd 10697 8 SCD SCD NNP cord-010119-t1x9gknd 10697 9 patients patient NNS cord-010119-t1x9gknd 10697 10 is be VBZ cord-010119-t1x9gknd 10697 11 alloimmunization alloimmunization NN cord-010119-t1x9gknd 10697 12 to to IN cord-010119-t1x9gknd 10697 13 RBC RBC NNP cord-010119-t1x9gknd 10697 14 antigens antigen NNS cord-010119-t1x9gknd 10697 15 . . . cord-010119-t1x9gknd 10698 1 To to TO cord-010119-t1x9gknd 10698 2 prevent prevent VB cord-010119-t1x9gknd 10698 3 alloimmunization alloimmunization NN cord-010119-t1x9gknd 10698 4 , , , cord-010119-t1x9gknd 10698 5 transfusion transfusion NN cord-010119-t1x9gknd 10698 6 with with IN cord-010119-t1x9gknd 10698 7 RBCs rbc NNS cord-010119-t1x9gknd 10698 8 negative negative JJ cord-010119-t1x9gknd 10698 9 for for IN cord-010119-t1x9gknd 10698 10 C C NNP cord-010119-t1x9gknd 10698 11 , , , cord-010119-t1x9gknd 10698 12 E E NNP cord-010119-t1x9gknd 10698 13 , , , cord-010119-t1x9gknd 10698 14 and and CC cord-010119-t1x9gknd 10698 15 K K NNP cord-010119-t1x9gknd 10698 16 antigens antigen NNS cord-010119-t1x9gknd 10698 17 has have VBZ cord-010119-t1x9gknd 10698 18 been be VBN cord-010119-t1x9gknd 10698 19 advocated advocate VBN cord-010119-t1x9gknd 10698 20 . . . cord-010119-t1x9gknd 10699 1 This this DT cord-010119-t1x9gknd 10699 2 has have VBZ cord-010119-t1x9gknd 10699 3 led lead VBN cord-010119-t1x9gknd 10699 4 to to IN cord-010119-t1x9gknd 10699 5 reports report NNS cord-010119-t1x9gknd 10699 6 of of IN cord-010119-t1x9gknd 10699 7 reduction reduction NN cord-010119-t1x9gknd 10699 8 in in IN cord-010119-t1x9gknd 10699 9 the the DT cord-010119-t1x9gknd 10699 10 rate rate NN cord-010119-t1x9gknd 10699 11 of of IN cord-010119-t1x9gknd 10699 12 alloimmunization alloimmunization NN cord-010119-t1x9gknd 10699 13 and and CC cord-010119-t1x9gknd 10699 14 a a DT cord-010119-t1x9gknd 10699 15 decrease decrease NN cord-010119-t1x9gknd 10699 16 in in IN cord-010119-t1x9gknd 10699 17 hemolytic hemolytic JJ cord-010119-t1x9gknd 10699 18 transfusion transfusion NN cord-010119-t1x9gknd 10699 19 reactions reaction NNS cord-010119-t1x9gknd 10699 20 . . . cord-010119-t1x9gknd 10700 1 We -PRON- PRP cord-010119-t1x9gknd 10700 2 report report VBP cord-010119-t1x9gknd 10700 3 a a DT cord-010119-t1x9gknd 10700 4 summary summary NN cord-010119-t1x9gknd 10700 5 of of IN cord-010119-t1x9gknd 10700 6 our -PRON- PRP$ cord-010119-t1x9gknd 10700 7 three three CD cord-010119-t1x9gknd 10700 8 year year NN cord-010119-t1x9gknd 10700 9 experience experience NN cord-010119-t1x9gknd 10700 10 with with IN cord-010119-t1x9gknd 10700 11 the the DT cord-010119-t1x9gknd 10700 12 prophylactic prophylactic JJ cord-010119-t1x9gknd 10700 13 transfusion transfusion NN cord-010119-t1x9gknd 10700 14 of of IN cord-010119-t1x9gknd 10700 15 RBC RBC NNP cord-010119-t1x9gknd 10700 16 units unit NNS cord-010119-t1x9gknd 10700 17 negative negative JJ cord-010119-t1x9gknd 10700 18 for for IN cord-010119-t1x9gknd 10700 19 C C NNP cord-010119-t1x9gknd 10700 20 , , , cord-010119-t1x9gknd 10700 21 E E NNP cord-010119-t1x9gknd 10700 22 , , , cord-010119-t1x9gknd 10700 23 K K NNP cord-010119-t1x9gknd 10700 24 antigens antigen NNS cord-010119-t1x9gknd 10700 25 for for IN cord-010119-t1x9gknd 10700 26 SCD SCD NNP cord-010119-t1x9gknd 10700 27 patients patient NNS cord-010119-t1x9gknd 10700 28 during during IN cord-010119-t1x9gknd 10700 29 red red JJ cord-010119-t1x9gknd 10700 30 blood blood NN cord-010119-t1x9gknd 10700 31 cell cell NN cord-010119-t1x9gknd 10700 32 exchange exchange NN cord-010119-t1x9gknd 10700 33 transfusions transfusion NNS cord-010119-t1x9gknd 10700 34 ( ( -LRB- cord-010119-t1x9gknd 10700 35 RBCx RBCx NNP cord-010119-t1x9gknd 10700 36 ) ) -RRB- cord-010119-t1x9gknd 10700 37 . . . cord-010119-t1x9gknd 10701 1 Study Study NNP cord-010119-t1x9gknd 10701 2 Design Design NNP cord-010119-t1x9gknd 10701 3 / / SYM cord-010119-t1x9gknd 10701 4 Method method NN cord-010119-t1x9gknd 10701 5 : : : cord-010119-t1x9gknd 10702 1 Retrospective retrospective JJ cord-010119-t1x9gknd 10702 2 review review NN cord-010119-t1x9gknd 10702 3 of of IN cord-010119-t1x9gknd 10702 4 10 10 CD cord-010119-t1x9gknd 10702 5 SCD SCD NNP cord-010119-t1x9gknd 10702 6 patients patient NNS cord-010119-t1x9gknd 10702 7 with with IN cord-010119-t1x9gknd 10702 8 a a DT cord-010119-t1x9gknd 10702 9 history history NN cord-010119-t1x9gknd 10702 10 of of IN cord-010119-t1x9gknd 10702 11 stroke stroke NN cord-010119-t1x9gknd 10702 12 , , , cord-010119-t1x9gknd 10702 13 refractory refractory JJ cord-010119-t1x9gknd 10702 14 sickle sickle NN cord-010119-t1x9gknd 10702 15 pain pain NN cord-010119-t1x9gknd 10702 16 crisis crisis NN cord-010119-t1x9gknd 10702 17 and and CC cord-010119-t1x9gknd 10702 18 priapism priapism NN cord-010119-t1x9gknd 10702 19 was be VBD cord-010119-t1x9gknd 10702 20 done do VBN cord-010119-t1x9gknd 10702 21 . . . cord-010119-t1x9gknd 10703 1 RBCx RBCx NNP cord-010119-t1x9gknd 10703 2 was be VBD cord-010119-t1x9gknd 10703 3 performed perform VBN cord-010119-t1x9gknd 10703 4 every every DT cord-010119-t1x9gknd 10703 5 4 4 CD cord-010119-t1x9gknd 10703 6 to to TO cord-010119-t1x9gknd 10703 7 8 8 CD cord-010119-t1x9gknd 10703 8 weeks week NNS cord-010119-t1x9gknd 10703 9 from from IN cord-010119-t1x9gknd 10703 10 December December NNP cord-010119-t1x9gknd 10703 11 2013 2013 CD cord-010119-t1x9gknd 10703 12 to to IN cord-010119-t1x9gknd 10703 13 March March NNP cord-010119-t1x9gknd 10703 14 2017 2017 CD cord-010119-t1x9gknd 10703 15 . . . cord-010119-t1x9gknd 10704 1 Blood blood NN cord-010119-t1x9gknd 10704 2 bank bank NN cord-010119-t1x9gknd 10704 3 work work NN cord-010119-t1x9gknd 10704 4 - - HYPH cord-010119-t1x9gknd 10704 5 up up NN cord-010119-t1x9gknd 10704 6 used use VBD cord-010119-t1x9gknd 10704 7 the the DT cord-010119-t1x9gknd 10704 8 MTS MTS NNP cord-010119-t1x9gknd 10704 9 gel gel NN cord-010119-t1x9gknd 10704 10 method method NN cord-010119-t1x9gknd 10704 11 for for IN cord-010119-t1x9gknd 10704 12 antibody antibody NN cord-010119-t1x9gknd 10704 13 screen screen NN cord-010119-t1x9gknd 10704 14 and and CC cord-010119-t1x9gknd 10704 15 identification identification NN cord-010119-t1x9gknd 10704 16 . . . cord-010119-t1x9gknd 10705 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10705 2 hospital hospital NN cord-010119-t1x9gknd 10705 3 - - HYPH cord-010119-t1x9gknd 10705 4 based base VBN cord-010119-t1x9gknd 10705 5 donor donor NN cord-010119-t1x9gknd 10705 6 center center NN cord-010119-t1x9gknd 10705 7 proactively proactively RB cord-010119-t1x9gknd 10705 8 works work VBZ cord-010119-t1x9gknd 10705 9 with with IN cord-010119-t1x9gknd 10705 10 the the DT cord-010119-t1x9gknd 10705 11 hospital hospital NN cord-010119-t1x9gknd 10705 12 blood blood NN cord-010119-t1x9gknd 10705 13 bank bank NNP cord-010119-t1x9gknd 10705 14 in in IN cord-010119-t1x9gknd 10705 15 preparing prepare VBG cord-010119-t1x9gknd 10705 16 these these DT cord-010119-t1x9gknd 10705 17 units unit NNS cord-010119-t1x9gknd 10705 18 in in IN cord-010119-t1x9gknd 10705 19 a a DT cord-010119-t1x9gknd 10705 20 timely timely JJ cord-010119-t1x9gknd 10705 21 manner manner NN cord-010119-t1x9gknd 10705 22 . . . cord-010119-t1x9gknd 10706 1 Results result NNS cord-010119-t1x9gknd 10706 2 / / SYM cord-010119-t1x9gknd 10706 3 Finding finding NN cord-010119-t1x9gknd 10706 4 : : : cord-010119-t1x9gknd 10706 5 A a DT cord-010119-t1x9gknd 10706 6 total total NN cord-010119-t1x9gknd 10706 7 of of IN cord-010119-t1x9gknd 10706 8 10 10 CD cord-010119-t1x9gknd 10706 9 patients patient NNS cord-010119-t1x9gknd 10706 10 , , , cord-010119-t1x9gknd 10706 11 3 3 CD cord-010119-t1x9gknd 10706 12 females female NNS cord-010119-t1x9gknd 10706 13 and and CC cord-010119-t1x9gknd 10706 14 7 7 CD cord-010119-t1x9gknd 10706 15 males male NNS cord-010119-t1x9gknd 10706 16 , , , cord-010119-t1x9gknd 10706 17 who who WP cord-010119-t1x9gknd 10706 18 underwent undergo VBD cord-010119-t1x9gknd 10706 19 a a DT cord-010119-t1x9gknd 10706 20 total total NN cord-010119-t1x9gknd 10706 21 of of IN cord-010119-t1x9gknd 10706 22 178 178 CD cord-010119-t1x9gknd 10706 23 RBCx RBCx NNS cord-010119-t1x9gknd 10706 24 from from IN cord-010119-t1x9gknd 10706 25 October October NNP cord-010119-t1x9gknd 10706 26 2013 2013 CD cord-010119-t1x9gknd 10706 27 to to IN cord-010119-t1x9gknd 10706 28 March March NNP cord-010119-t1x9gknd 10706 29 2017 2017 CD cord-010119-t1x9gknd 10706 30 , , , cord-010119-t1x9gknd 10706 31 using use VBG cord-010119-t1x9gknd 10706 32 an an DT cord-010119-t1x9gknd 10706 33 average average JJ cord-010119-t1x9gknd 10706 34 number number NN cord-010119-t1x9gknd 10706 35 of of IN cord-010119-t1x9gknd 10706 36 7 7 CD cord-010119-t1x9gknd 10706 37 RBC RBC NNP cord-010119-t1x9gknd 10706 38 units unit NNS cord-010119-t1x9gknd 10706 39 per per IN cord-010119-t1x9gknd 10706 40 RBCx RBCx NNS cord-010119-t1x9gknd 10706 41 . . . cord-010119-t1x9gknd 10707 1 RBC RBC NNP cord-010119-t1x9gknd 10707 2 units unit NNS cord-010119-t1x9gknd 10707 3 negative negative JJ cord-010119-t1x9gknd 10707 4 for for IN cord-010119-t1x9gknd 10707 5 C C NNP cord-010119-t1x9gknd 10707 6 , , , cord-010119-t1x9gknd 10707 7 E E NNP cord-010119-t1x9gknd 10707 8 , , , cord-010119-t1x9gknd 10707 9 and and CC cord-010119-t1x9gknd 10707 10 K K NNP cord-010119-t1x9gknd 10707 11 antigens antigen NNS cord-010119-t1x9gknd 10707 12 were be VBD cord-010119-t1x9gknd 10707 13 used use VBN cord-010119-t1x9gknd 10707 14 during during IN cord-010119-t1x9gknd 10707 15 RBCx RBCx NNS cord-010119-t1x9gknd 10707 16 for for IN cord-010119-t1x9gknd 10707 17 8 8 CD cord-010119-t1x9gknd 10707 18 patients patient NNS cord-010119-t1x9gknd 10707 19 . . . cord-010119-t1x9gknd 10708 1 Two two CD cord-010119-t1x9gknd 10708 2 patients patient NNS cord-010119-t1x9gknd 10708 3 positive positive JJ cord-010119-t1x9gknd 10708 4 for for IN cord-010119-t1x9gknd 10708 5 C c NN cord-010119-t1x9gknd 10708 6 antigen antigen NN cord-010119-t1x9gknd 10708 7 underwent undergo VBD cord-010119-t1x9gknd 10708 8 RBCx rbcx NN cord-010119-t1x9gknd 10708 9 , , , cord-010119-t1x9gknd 10708 10 using use VBG cord-010119-t1x9gknd 10708 11 E e NN cord-010119-t1x9gknd 10708 12 and and CC cord-010119-t1x9gknd 10708 13 K K NNP cord-010119-t1x9gknd 10708 14 antigen antigen NN cord-010119-t1x9gknd 10708 15 negative negative JJ cord-010119-t1x9gknd 10708 16 RBC RBC NNP cord-010119-t1x9gknd 10708 17 units unit NNS cord-010119-t1x9gknd 10708 18 . . . cord-010119-t1x9gknd 10709 1 Review Review NNP cord-010119-t1x9gknd 10709 2 of of IN cord-010119-t1x9gknd 10709 3 the the DT cord-010119-t1x9gknd 10709 4 antibody antibody NN cord-010119-t1x9gknd 10709 5 screen screen NN cord-010119-t1x9gknd 10709 6 test test NN cord-010119-t1x9gknd 10709 7 results result NNS cord-010119-t1x9gknd 10709 8 performed perform VBN cord-010119-t1x9gknd 10709 9 prior prior RB cord-010119-t1x9gknd 10709 10 to to IN cord-010119-t1x9gknd 10709 11 each each DT cord-010119-t1x9gknd 10709 12 of of IN cord-010119-t1x9gknd 10709 13 the the DT cord-010119-t1x9gknd 10709 14 178 178 CD cord-010119-t1x9gknd 10709 15 RCE RCE NNP cord-010119-t1x9gknd 10709 16 showed show VBD cord-010119-t1x9gknd 10709 17 that that IN cord-010119-t1x9gknd 10709 18 no no DT cord-010119-t1x9gknd 10709 19 new new JJ cord-010119-t1x9gknd 10709 20 clinically clinically RB cord-010119-t1x9gknd 10709 21 significant significant JJ cord-010119-t1x9gknd 10709 22 alloantibodies alloantibody NNS cord-010119-t1x9gknd 10709 23 were be VBD cord-010119-t1x9gknd 10709 24 formed form VBN cord-010119-t1x9gknd 10709 25 after after IN cord-010119-t1x9gknd 10709 26 exposure exposure NN cord-010119-t1x9gknd 10709 27 to to IN cord-010119-t1x9gknd 10709 28 multiple multiple JJ cord-010119-t1x9gknd 10709 29 RBC RBC NNP cord-010119-t1x9gknd 10709 30 units unit NNS cord-010119-t1x9gknd 10709 31 . . . cord-010119-t1x9gknd 10710 1 Conclusion conclusion NN cord-010119-t1x9gknd 10710 2 : : : cord-010119-t1x9gknd 10711 1 Although although IN cord-010119-t1x9gknd 10711 2 there there EX cord-010119-t1x9gknd 10711 3 is be VBZ cord-010119-t1x9gknd 10711 4 no no DT cord-010119-t1x9gknd 10711 5 consistent consistent JJ cord-010119-t1x9gknd 10711 6 standard standard NN cord-010119-t1x9gknd 10711 7 of of IN cord-010119-t1x9gknd 10711 8 care care NN cord-010119-t1x9gknd 10711 9 in in IN cord-010119-t1x9gknd 10711 10 transfusion transfusion NN cord-010119-t1x9gknd 10711 11 practice practice NN cord-010119-t1x9gknd 10711 12 related relate VBN cord-010119-t1x9gknd 10711 13 to to IN cord-010119-t1x9gknd 10711 14 the the DT cord-010119-t1x9gknd 10711 15 extent extent NN cord-010119-t1x9gknd 10711 16 of of IN cord-010119-t1x9gknd 10711 17 antigen antigen NN cord-010119-t1x9gknd 10711 18 matching matching NN cord-010119-t1x9gknd 10711 19 for for IN cord-010119-t1x9gknd 10711 20 SCD SCD NNP cord-010119-t1x9gknd 10711 21 patients patient NNS cord-010119-t1x9gknd 10711 22 , , , cord-010119-t1x9gknd 10711 23 studies study NNS cord-010119-t1x9gknd 10711 24 suggest suggest VBP cord-010119-t1x9gknd 10711 25 that that IN cord-010119-t1x9gknd 10711 26 the the DT cord-010119-t1x9gknd 10711 27 standard standard NN cord-010119-t1x9gknd 10711 28 of of IN cord-010119-t1x9gknd 10711 29 care care NN cord-010119-t1x9gknd 10711 30 for for IN cord-010119-t1x9gknd 10711 31 transfusion transfusion NN cord-010119-t1x9gknd 10711 32 of of IN cord-010119-t1x9gknd 10711 33 all all DT cord-010119-t1x9gknd 10711 34 patients patient NNS cord-010119-t1x9gknd 10711 35 with with IN cord-010119-t1x9gknd 10711 36 SCD SCD NNP cord-010119-t1x9gknd 10711 37 is be VBZ cord-010119-t1x9gknd 10711 38 to to TO cord-010119-t1x9gknd 10711 39 provide provide VB cord-010119-t1x9gknd 10711 40 RBC RBC NNP cord-010119-t1x9gknd 10711 41 negative negative JJ cord-010119-t1x9gknd 10711 42 for for IN cord-010119-t1x9gknd 10711 43 C C NNP cord-010119-t1x9gknd 10711 44 , , , cord-010119-t1x9gknd 10711 45 E E NNP cord-010119-t1x9gknd 10711 46 , , , cord-010119-t1x9gknd 10711 47 and and CC cord-010119-t1x9gknd 10711 48 K K NNP cord-010119-t1x9gknd 10711 49 antigens antigen NNS cord-010119-t1x9gknd 10711 50 . . . cord-010119-t1x9gknd 10712 1 This this DT cord-010119-t1x9gknd 10712 2 ability ability NN cord-010119-t1x9gknd 10712 3 to to TO cord-010119-t1x9gknd 10712 4 find find VB cord-010119-t1x9gknd 10712 5 these these DT cord-010119-t1x9gknd 10712 6 rare rare JJ cord-010119-t1x9gknd 10712 7 units unit NNS cord-010119-t1x9gknd 10712 8 is be VBZ cord-010119-t1x9gknd 10712 9 also also RB cord-010119-t1x9gknd 10712 10 affected affect VBN cord-010119-t1x9gknd 10712 11 by by IN cord-010119-t1x9gknd 10712 12 the the DT cord-010119-t1x9gknd 10712 13 characteristics characteristic NNS cord-010119-t1x9gknd 10712 14 of of IN cord-010119-t1x9gknd 10712 15 one one NN cord-010119-t1x9gknd 10712 16 's 's POS cord-010119-t1x9gknd 10712 17 institution institution NN cord-010119-t1x9gknd 10712 18 and and CC cord-010119-t1x9gknd 10712 19 blood blood NN cord-010119-t1x9gknd 10712 20 supplier supplier NN cord-010119-t1x9gknd 10712 21 . . . cord-010119-t1x9gknd 10713 1 It -PRON- PRP cord-010119-t1x9gknd 10713 2 is be VBZ cord-010119-t1x9gknd 10713 3 an an DT cord-010119-t1x9gknd 10713 4 advantage advantage NN cord-010119-t1x9gknd 10713 5 to to TO cord-010119-t1x9gknd 10713 6 have have VB cord-010119-t1x9gknd 10713 7 a a DT cord-010119-t1x9gknd 10713 8 hospital hospital NN cord-010119-t1x9gknd 10713 9 based base VBN cord-010119-t1x9gknd 10713 10 donor donor NN cord-010119-t1x9gknd 10713 11 center center NN cord-010119-t1x9gknd 10713 12 to to TO cord-010119-t1x9gknd 10713 13 work work VB cord-010119-t1x9gknd 10713 14 with with IN cord-010119-t1x9gknd 10713 15 , , , cord-010119-t1x9gknd 10713 16 as as IN cord-010119-t1x9gknd 10713 17 we -PRON- PRP cord-010119-t1x9gknd 10713 18 proactively proactively RB cord-010119-t1x9gknd 10713 19 collaborate collaborate VBP cord-010119-t1x9gknd 10713 20 with with IN cord-010119-t1x9gknd 10713 21 them -PRON- PRP cord-010119-t1x9gknd 10713 22 to to TO cord-010119-t1x9gknd 10713 23 provide provide VB cord-010119-t1x9gknd 10713 24 these these DT cord-010119-t1x9gknd 10713 25 rare rare JJ cord-010119-t1x9gknd 10713 26 units unit NNS cord-010119-t1x9gknd 10713 27 . . . cord-010119-t1x9gknd 10714 1 The the DT cord-010119-t1x9gknd 10714 2 approach approach NN cord-010119-t1x9gknd 10714 3 by by IN cord-010119-t1x9gknd 10714 4 our -PRON- PRP$ cord-010119-t1x9gknd 10714 5 institution institution NN cord-010119-t1x9gknd 10714 6 to to TO cord-010119-t1x9gknd 10714 7 transfuse transfuse VB cord-010119-t1x9gknd 10714 8 RBC RBC NNP cord-010119-t1x9gknd 10714 9 units unit NNS cord-010119-t1x9gknd 10714 10 negative negative JJ cord-010119-t1x9gknd 10714 11 for for IN cord-010119-t1x9gknd 10714 12 C C NNP cord-010119-t1x9gknd 10714 13 , , , cord-010119-t1x9gknd 10714 14 E E NNP cord-010119-t1x9gknd 10714 15 , , , cord-010119-t1x9gknd 10714 16 K K NNP cord-010119-t1x9gknd 10714 17 or or CC cord-010119-t1x9gknd 10714 18 Study Study NNP cord-010119-t1x9gknd 10714 19 Design Design NNP cord-010119-t1x9gknd 10714 20 / / SYM cord-010119-t1x9gknd 10714 21 Method method NN cord-010119-t1x9gknd 10714 22 : : : cord-010119-t1x9gknd 10714 23 Venous venous JJ cord-010119-t1x9gknd 10714 24 blood blood NN cord-010119-t1x9gknd 10714 25 specimens specimen NNS cord-010119-t1x9gknd 10714 26 of of IN cord-010119-t1x9gknd 10714 27 168 168 CD cord-010119-t1x9gknd 10714 28 healthy healthy JJ cord-010119-t1x9gknd 10714 29 volunteers volunteer NNS cord-010119-t1x9gknd 10714 30 were be VBD cord-010119-t1x9gknd 10714 31 collected collect VBN cord-010119-t1x9gknd 10714 32 before before IN cord-010119-t1x9gknd 10714 33 blood blood NN cord-010119-t1x9gknd 10714 34 donation donation NN cord-010119-t1x9gknd 10714 35 and and CC cord-010119-t1x9gknd 10714 36 after after IN cord-010119-t1x9gknd 10714 37 blood blood NN cord-010119-t1x9gknd 10714 38 donation donation NN cord-010119-t1x9gknd 10714 39 immediately immediately RB cord-010119-t1x9gknd 10714 40 , , , cord-010119-t1x9gknd 10714 41 1 1 CD cord-010119-t1x9gknd 10714 42 day day NN cord-010119-t1x9gknd 10714 43 , , , cord-010119-t1x9gknd 10714 44 1 1 CD cord-010119-t1x9gknd 10714 45 week week NN cord-010119-t1x9gknd 10714 46 , , , cord-010119-t1x9gknd 10714 47 4 4 CD cord-010119-t1x9gknd 10714 48 weeks week NNS cord-010119-t1x9gknd 10714 49 , , , cord-010119-t1x9gknd 10714 50 and and CC cord-010119-t1x9gknd 10714 51 12 12 CD cord-010119-t1x9gknd 10714 52 weeks week NNS cord-010119-t1x9gknd 10714 53 among among IN cord-010119-t1x9gknd 10714 54 men man NNS cord-010119-t1x9gknd 10714 55 and and CC cord-010119-t1x9gknd 10714 56 16 16 CD cord-010119-t1x9gknd 10714 57 weeks week NNS cord-010119-t1x9gknd 10714 58 among among IN cord-010119-t1x9gknd 10714 59 women woman NNS cord-010119-t1x9gknd 10714 60 . . . cord-010119-t1x9gknd 10715 1 Immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 10715 2 G G NNP cord-010119-t1x9gknd 10715 3 ( ( -LRB- cord-010119-t1x9gknd 10715 4 IgG IgG NNP cord-010119-t1x9gknd 10715 5 ) ) -RRB- cord-010119-t1x9gknd 10715 6 , , , cord-010119-t1x9gknd 10715 7 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 10715 8 M M NNP cord-010119-t1x9gknd 10715 9 ( ( -LRB- cord-010119-t1x9gknd 10715 10 IgM IgM NNP cord-010119-t1x9gknd 10715 11 ) ) -RRB- cord-010119-t1x9gknd 10715 12 , , , cord-010119-t1x9gknd 10715 13 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 10715 14 A a NN cord-010119-t1x9gknd 10715 15 ( ( -LRB- cord-010119-t1x9gknd 10715 16 IgA)and IgA)and NNP cord-010119-t1x9gknd 10715 17 complement complement NN cord-010119-t1x9gknd 10715 18 component component NN cord-010119-t1x9gknd 10715 19 3 3 CD cord-010119-t1x9gknd 10715 20 ( ( -LRB- cord-010119-t1x9gknd 10715 21 C3 C3 NNP cord-010119-t1x9gknd 10715 22 ) ) -RRB- cord-010119-t1x9gknd 10715 23 , , , cord-010119-t1x9gknd 10715 24 red red JJ cord-010119-t1x9gknd 10715 25 blood blood NN cord-010119-t1x9gknd 10715 26 cell cell NN cord-010119-t1x9gknd 10715 27 ( ( -LRB- cord-010119-t1x9gknd 10715 28 RBC RBC NNP cord-010119-t1x9gknd 10715 29 ) ) -RRB- cord-010119-t1x9gknd 10715 30 , , , cord-010119-t1x9gknd 10715 31 white white JJ cord-010119-t1x9gknd 10715 32 blood blood NN cord-010119-t1x9gknd 10715 33 cell cell NN cord-010119-t1x9gknd 10715 34 count count NN cord-010119-t1x9gknd 10715 35 ( ( -LRB- cord-010119-t1x9gknd 10715 36 WBC WBC NNP cord-010119-t1x9gknd 10715 37 ) ) -RRB- cord-010119-t1x9gknd 10715 38 , , , cord-010119-t1x9gknd 10715 39 hemoglobin hemoglobin NN cord-010119-t1x9gknd 10715 40 ( ( -LRB- cord-010119-t1x9gknd 10715 41 Hb Hb NNP cord-010119-t1x9gknd 10715 42 ) ) -RRB- cord-010119-t1x9gknd 10715 43 , , , cord-010119-t1x9gknd 10715 44 hematocrit hematocrit NN cord-010119-t1x9gknd 10715 45 ( ( -LRB- cord-010119-t1x9gknd 10715 46 HCT HCT NNP cord-010119-t1x9gknd 10715 47 ) ) -RRB- cord-010119-t1x9gknd 10715 48 , , , cord-010119-t1x9gknd 10715 49 and and CC cord-010119-t1x9gknd 10715 50 serum serum NN cord-010119-t1x9gknd 10715 51 iron iron NN cord-010119-t1x9gknd 10715 52 ( ( -LRB- cord-010119-t1x9gknd 10715 53 Fe Fe NNP cord-010119-t1x9gknd 10715 54 ) ) -RRB- cord-010119-t1x9gknd 10715 55 , , , cord-010119-t1x9gknd 10715 56 were be VBD cord-010119-t1x9gknd 10715 57 measured measure VBN cord-010119-t1x9gknd 10715 58 to to TO cord-010119-t1x9gknd 10715 59 monitor monitor VB cord-010119-t1x9gknd 10715 60 he -PRON- PRP cord-010119-t1x9gknd 10715 61 dynamic dynamic JJ cord-010119-t1x9gknd 10715 62 changes change NNS cord-010119-t1x9gknd 10715 63 of of IN cord-010119-t1x9gknd 10715 64 these these DT cord-010119-t1x9gknd 10715 65 biomarkers biomarker NNS cord-010119-t1x9gknd 10715 66 and and CC cord-010119-t1x9gknd 10715 67 blood blood NN cord-010119-t1x9gknd 10715 68 quality quality NN cord-010119-t1x9gknd 10715 69 . . . cord-010119-t1x9gknd 10716 1 Results/ Results/ . cord-010119-t1x9gknd 10717 1 Finding finding NN cord-010119-t1x9gknd 10717 2 : : : cord-010119-t1x9gknd 10717 3 the the DT cord-010119-t1x9gknd 10717 4 level level NN cord-010119-t1x9gknd 10717 5 of of IN cord-010119-t1x9gknd 10717 6 IgG igg NN cord-010119-t1x9gknd 10717 7 slightly slightly RB cord-010119-t1x9gknd 10717 8 decreased decrease VBD cord-010119-t1x9gknd 10717 9 after after IN cord-010119-t1x9gknd 10717 10 blood blood NN cord-010119-t1x9gknd 10717 11 donated donate VBN cord-010119-t1x9gknd 10717 12 immediately immediately RB cord-010119-t1x9gknd 10717 13 , , , cord-010119-t1x9gknd 10717 14 IgA IgA NNP cord-010119-t1x9gknd 10717 15 and and CC cord-010119-t1x9gknd 10717 16 C3 C3 NNP cord-010119-t1x9gknd 10717 17 decreased decrease VBD cord-010119-t1x9gknd 10717 18 significantly significantly RB cord-010119-t1x9gknd 10717 19 but but CC cord-010119-t1x9gknd 10717 20 still still RB cord-010119-t1x9gknd 10717 21 within within IN cord-010119-t1x9gknd 10717 22 their -PRON- PRP$ cord-010119-t1x9gknd 10717 23 normal normal JJ cord-010119-t1x9gknd 10717 24 ranges range NNS cord-010119-t1x9gknd 10717 25 , , , cord-010119-t1x9gknd 10717 26 IgM IgM NNP cord-010119-t1x9gknd 10717 27 did do VBD cord-010119-t1x9gknd 10717 28 not not RB cord-010119-t1x9gknd 10717 29 change change VB cord-010119-t1x9gknd 10717 30 after after IN cord-010119-t1x9gknd 10717 31 blood blood NN cord-010119-t1x9gknd 10717 32 donation donation NN cord-010119-t1x9gknd 10717 33 . . . cord-010119-t1x9gknd 10718 1 The the DT cord-010119-t1x9gknd 10718 2 level level NN cord-010119-t1x9gknd 10718 3 of of IN cord-010119-t1x9gknd 10718 4 IgA IgA NNP cord-010119-t1x9gknd 10718 5 significantly significantly RB cord-010119-t1x9gknd 10718 6 decreased decrease VBD cord-010119-t1x9gknd 10718 7 at at IN cord-010119-t1x9gknd 10718 8 12 12 CD cord-010119-t1x9gknd 10718 9 weeks week NNS cord-010119-t1x9gknd 10718 10 among among IN cord-010119-t1x9gknd 10718 11 men man NNS cord-010119-t1x9gknd 10718 12 and and CC cord-010119-t1x9gknd 10718 13 16 16 CD cord-010119-t1x9gknd 10718 14 weeks week NNS cord-010119-t1x9gknd 10718 15 among among IN cord-010119-t1x9gknd 10718 16 women woman NNS cord-010119-t1x9gknd 10718 17 , , , cord-010119-t1x9gknd 10718 18 while while IN cord-010119-t1x9gknd 10718 19 C3 C3 NNP cord-010119-t1x9gknd 10718 20 significantly significantly RB cord-010119-t1x9gknd 10718 21 increased increase VBD cord-010119-t1x9gknd 10718 22 at at IN cord-010119-t1x9gknd 10718 23 the the DT cord-010119-t1x9gknd 10718 24 same same JJ cord-010119-t1x9gknd 10718 25 time time NN cord-010119-t1x9gknd 10718 26 period period NN cord-010119-t1x9gknd 10718 27 . . . cord-010119-t1x9gknd 10719 1 IgG IgG NNP cord-010119-t1x9gknd 10719 2 , , , cord-010119-t1x9gknd 10719 3 RBC RBC NNP cord-010119-t1x9gknd 10719 4 , , , cord-010119-t1x9gknd 10719 5 Hb Hb NNP cord-010119-t1x9gknd 10719 6 , , , cord-010119-t1x9gknd 10719 7 HCT HCT NNP cord-010119-t1x9gknd 10719 8 and and CC cord-010119-t1x9gknd 10719 9 Fe Fe NNP cord-010119-t1x9gknd 10719 10 started start VBD cord-010119-t1x9gknd 10719 11 to to TO cord-010119-t1x9gknd 10719 12 recover recover VB cord-010119-t1x9gknd 10719 13 1 1 CD cord-010119-t1x9gknd 10719 14 week week NN cord-010119-t1x9gknd 10719 15 after after IN cord-010119-t1x9gknd 10719 16 blood blood NN cord-010119-t1x9gknd 10719 17 donated donate VBN cord-010119-t1x9gknd 10719 18 and and CC cord-010119-t1x9gknd 10719 19 reached reach VBD cord-010119-t1x9gknd 10719 20 their -PRON- PRP$ cord-010119-t1x9gknd 10719 21 levels level NNS cord-010119-t1x9gknd 10719 22 before before IN cord-010119-t1x9gknd 10719 23 blood blood NN cord-010119-t1x9gknd 10719 24 donated donate VBN cord-010119-t1x9gknd 10719 25 within within IN cord-010119-t1x9gknd 10719 26 12 12 CD cord-010119-t1x9gknd 10719 27 weeks week NNS cord-010119-t1x9gknd 10719 28 among among IN cord-010119-t1x9gknd 10719 29 men man NNS cord-010119-t1x9gknd 10719 30 and and CC cord-010119-t1x9gknd 10719 31 16 16 CD cord-010119-t1x9gknd 10719 32 weeks week NNS cord-010119-t1x9gknd 10719 33 among among IN cord-010119-t1x9gknd 10719 34 women woman NNS cord-010119-t1x9gknd 10719 35 . . . cord-010119-t1x9gknd 10720 1 Conclusion conclusion NN cord-010119-t1x9gknd 10720 2 : : : cord-010119-t1x9gknd 10720 3 the the DT cord-010119-t1x9gknd 10720 4 biomarkers biomarker NNS cord-010119-t1x9gknd 10720 5 mutually mutually RB cord-010119-t1x9gknd 10720 6 changed change VBD cord-010119-t1x9gknd 10720 7 over over IN cord-010119-t1x9gknd 10720 8 the the DT cord-010119-t1x9gknd 10720 9 course course NN cord-010119-t1x9gknd 10720 10 of of IN cord-010119-t1x9gknd 10720 11 12 12 CD cord-010119-t1x9gknd 10720 12 weeks week NNS cord-010119-t1x9gknd 10720 13 among among IN cord-010119-t1x9gknd 10720 14 men man NNS cord-010119-t1x9gknd 10720 15 and and CC cord-010119-t1x9gknd 10720 16 16 16 CD cord-010119-t1x9gknd 10720 17 weeks week NNS cord-010119-t1x9gknd 10720 18 among among IN cord-010119-t1x9gknd 10720 19 women woman NNS cord-010119-t1x9gknd 10720 20 . . . cord-010119-t1x9gknd 10721 1 Donating donate VBG cord-010119-t1x9gknd 10721 2 400 400 CD cord-010119-t1x9gknd 10721 3 ml ml NNS cord-010119-t1x9gknd 10721 4 blood blood NN cord-010119-t1x9gknd 10721 5 will will MD cord-010119-t1x9gknd 10721 6 not not RB cord-010119-t1x9gknd 10721 7 significantly significantly RB cord-010119-t1x9gknd 10721 8 affect affect VB cord-010119-t1x9gknd 10721 9 overall overall JJ cord-010119-t1x9gknd 10721 10 blood blood NN cord-010119-t1x9gknd 10721 11 quality quality NN cord-010119-t1x9gknd 10721 12 . . . cord-010119-t1x9gknd 10722 1 Utilizing utilize VBG cord-010119-t1x9gknd 10722 2 Amicus Amicus NNP cord-010119-t1x9gknd 10722 3 Dxt Dxt NNP cord-010119-t1x9gknd 10722 4 Relay Relay NNP cord-010119-t1x9gknd 10722 5 Data Data NNP cord-010119-t1x9gknd 10722 6 Managment Managment NNP cord-010119-t1x9gknd 10722 7 Solution Solution NNP cord-010119-t1x9gknd 10722 8 to to TO cord-010119-t1x9gknd 10722 9 Increase increase VB cord-010119-t1x9gknd 10722 10 Platelet platelet NN cord-010119-t1x9gknd 10722 11 Split Split NNP cord-010119-t1x9gknd 10722 12 Rate rate NN cord-010119-t1x9gknd 10722 13 and and CC cord-010119-t1x9gknd 10722 14 Improve improve VB cord-010119-t1x9gknd 10723 1 Amicus Amicus NNP cord-010119-t1x9gknd 10723 2 Productivity Productivity NNP cord-010119-t1x9gknd 10724 1 Janelle Janelle NNP cord-010119-t1x9gknd 10724 2 Wilhelm Wilhelm NNP cord-010119-t1x9gknd 10724 3 * * NFP cord-010119-t1x9gknd 10724 4 and and CC cord-010119-t1x9gknd 10724 5 Jennifer Jennifer NNP cord-010119-t1x9gknd 10724 6 Kaluza Kaluza NNP cord-010119-t1x9gknd 10724 7 . . . cord-010119-t1x9gknd 10725 1 Memorial Memorial NNP cord-010119-t1x9gknd 10725 2 Blood Blood NNP cord-010119-t1x9gknd 10725 3 Centers Centers NNPS cord-010119-t1x9gknd 10725 4 Background Background NNP cord-010119-t1x9gknd 10725 5 / / SYM cord-010119-t1x9gknd 10725 6 Case Case NNP cord-010119-t1x9gknd 10725 7 Studies Studies NNPS cord-010119-t1x9gknd 10725 8 : : : cord-010119-t1x9gknd 10726 1 With with IN cord-010119-t1x9gknd 10726 2 the the DT cord-010119-t1x9gknd 10726 3 increase increase NN cord-010119-t1x9gknd 10726 4 in in IN cord-010119-t1x9gknd 10726 5 platelet platelet NN cord-010119-t1x9gknd 10726 6 demand demand NN cord-010119-t1x9gknd 10726 7 and and CC cord-010119-t1x9gknd 10726 8 the the DT cord-010119-t1x9gknd 10726 9 opportunity opportunity NN cord-010119-t1x9gknd 10726 10 to to TO cord-010119-t1x9gknd 10726 11 export export VB cord-010119-t1x9gknd 10726 12 products product NNS cord-010119-t1x9gknd 10726 13 we -PRON- PRP cord-010119-t1x9gknd 10726 14 set set VBD cord-010119-t1x9gknd 10726 15 an an DT cord-010119-t1x9gknd 10726 16 initiative initiative NN cord-010119-t1x9gknd 10726 17 to to TO cord-010119-t1x9gknd 10726 18 increase increase VB cord-010119-t1x9gknd 10726 19 the the DT cord-010119-t1x9gknd 10726 20 platelet platelet NN cord-010119-t1x9gknd 10726 21 products product NNS cord-010119-t1x9gknd 10726 22 collected collect VBN cord-010119-t1x9gknd 10726 23 form form VBP cord-010119-t1x9gknd 10726 24 our -PRON- PRP$ cord-010119-t1x9gknd 10726 25 existing exist VBG cord-010119-t1x9gknd 10726 26 donor donor NN cord-010119-t1x9gknd 10726 27 base base NN cord-010119-t1x9gknd 10726 28 . . . cord-010119-t1x9gknd 10727 1 We -PRON- PRP cord-010119-t1x9gknd 10727 2 also also RB cord-010119-t1x9gknd 10727 3 faced face VBD cord-010119-t1x9gknd 10727 4 the the DT cord-010119-t1x9gknd 10727 5 challenge challenge NN cord-010119-t1x9gknd 10727 6 of of IN cord-010119-t1x9gknd 10727 7 managing manage VBG cord-010119-t1x9gknd 10727 8 multiple multiple JJ cord-010119-t1x9gknd 10727 9 collection collection NN cord-010119-t1x9gknd 10727 10 sites site NNS cord-010119-t1x9gknd 10727 11 in in IN cord-010119-t1x9gknd 10727 12 multiple multiple JJ cord-010119-t1x9gknd 10727 13 states state NNS cord-010119-t1x9gknd 10727 14 . . . cord-010119-t1x9gknd 10728 1 The the DT cord-010119-t1x9gknd 10728 2 decision decision NN cord-010119-t1x9gknd 10728 3 was be VBD cord-010119-t1x9gknd 10728 4 made make VBN cord-010119-t1x9gknd 10728 5 to to TO cord-010119-t1x9gknd 10728 6 implement implement VB cord-010119-t1x9gknd 10728 7 Amicus Amicus NNP cord-010119-t1x9gknd 10728 8 DXT DXT NNP cord-010119-t1x9gknd 10728 9 Relay Relay NNP cord-010119-t1x9gknd 10728 10 Data Data NNP cord-010119-t1x9gknd 10728 11 Management Management NNP cord-010119-t1x9gknd 10728 12 Solution Solution NNP cord-010119-t1x9gknd 10728 13 to to TO cord-010119-t1x9gknd 10728 14 provide provide VB cord-010119-t1x9gknd 10728 15 us -PRON- PRP cord-010119-t1x9gknd 10728 16 insight insight NN cord-010119-t1x9gknd 10728 17 into into IN cord-010119-t1x9gknd 10728 18 procedure procedure NN cord-010119-t1x9gknd 10728 19 details detail NNS cord-010119-t1x9gknd 10728 20 to to TO cord-010119-t1x9gknd 10728 21 make make VB cord-010119-t1x9gknd 10728 22 data datum NNS cord-010119-t1x9gknd 10728 23 driven drive VBN cord-010119-t1x9gknd 10728 24 decisions decision NNS cord-010119-t1x9gknd 10728 25 . . . cord-010119-t1x9gknd 10729 1 Day day NN cord-010119-t1x9gknd 10729 2 to to IN cord-010119-t1x9gknd 10729 3 day day NN cord-010119-t1x9gknd 10729 4 variability variability NN cord-010119-t1x9gknd 10729 5 previously previously RB cord-010119-t1x9gknd 10729 6 dipped dip VBD cord-010119-t1x9gknd 10729 7 as as RB cord-010119-t1x9gknd 10729 8 low low JJ cord-010119-t1x9gknd 10729 9 40 40 CD cord-010119-t1x9gknd 10729 10 % % NN cord-010119-t1x9gknd 10729 11 split split NN cord-010119-t1x9gknd 10729 12 forcing force VBG cord-010119-t1x9gknd 10729 13 reactive reactive JJ cord-010119-t1x9gknd 10729 14 planning planning NN cord-010119-t1x9gknd 10729 15 . . . cord-010119-t1x9gknd 10730 1 Study Study NNP cord-010119-t1x9gknd 10730 2 Design Design NNP cord-010119-t1x9gknd 10730 3 / / SYM cord-010119-t1x9gknd 10730 4 Method method NN cord-010119-t1x9gknd 10730 5 : : : cord-010119-t1x9gknd 10730 6 Incorporate incorporate VB cord-010119-t1x9gknd 10730 7 DXT DXT NNP cord-010119-t1x9gknd 10730 8 to to TO cord-010119-t1x9gknd 10730 9 strategically strategically RB cord-010119-t1x9gknd 10730 10 plan plan VB cord-010119-t1x9gknd 10730 11 our -PRON- PRP$ cord-010119-t1x9gknd 10730 12 day day NN cord-010119-t1x9gknd 10730 13 to to IN cord-010119-t1x9gknd 10730 14 day day NN cord-010119-t1x9gknd 10730 15 operations operation NNS cord-010119-t1x9gknd 10730 16 . . . cord-010119-t1x9gknd 10731 1 DXT DXT NNP cord-010119-t1x9gknd 10731 2 reports report NNS cord-010119-t1x9gknd 10731 3 were be VBD cord-010119-t1x9gknd 10731 4 monitored monitor VBN cord-010119-t1x9gknd 10731 5 by by IN cord-010119-t1x9gknd 10731 6 management management NN cord-010119-t1x9gknd 10731 7 and and CC cord-010119-t1x9gknd 10731 8 with with IN cord-010119-t1x9gknd 10731 9 the the DT cord-010119-t1x9gknd 10731 10 Fresenius Fresenius NNP cord-010119-t1x9gknd 10731 11 Kabi Kabi NNP cord-010119-t1x9gknd 10731 12 team team NN cord-010119-t1x9gknd 10731 13 for for IN cord-010119-t1x9gknd 10731 14 productivity productivity NN cord-010119-t1x9gknd 10731 15 by by IN cord-010119-t1x9gknd 10731 16 site site NN cord-010119-t1x9gknd 10731 17 , , , cord-010119-t1x9gknd 10731 18 phlebotomist phlebotomist NN cord-010119-t1x9gknd 10731 19 and and CC cord-010119-t1x9gknd 10731 20 device device NN cord-010119-t1x9gknd 10731 21 . . . cord-010119-t1x9gknd 10732 1 Reports report NNS cord-010119-t1x9gknd 10732 2 measured measure VBD cord-010119-t1x9gknd 10732 3 target target NN cord-010119-t1x9gknd 10732 4 vs vs IN cord-010119-t1x9gknd 10732 5 actual actual JJ cord-010119-t1x9gknd 10732 6 yield yield NN cord-010119-t1x9gknd 10732 7 , , , cord-010119-t1x9gknd 10732 8 donor donor NN cord-010119-t1x9gknd 10732 9 parameters parameter NNS cord-010119-t1x9gknd 10732 10 , , , cord-010119-t1x9gknd 10732 11 and and CC cord-010119-t1x9gknd 10732 12 procedure procedure NN cord-010119-t1x9gknd 10732 13 events event NNS cord-010119-t1x9gknd 10732 14 to to TO cord-010119-t1x9gknd 10732 15 perform perform VB cord-010119-t1x9gknd 10732 16 a a DT cord-010119-t1x9gknd 10732 17 donation donation NN cord-010119-t1x9gknd 10732 18 opportunity opportunity NN cord-010119-t1x9gknd 10732 19 analysis analysis NN cord-010119-t1x9gknd 10732 20 . . . cord-010119-t1x9gknd 10733 1 This this DT cord-010119-t1x9gknd 10733 2 allowed allow VBD cord-010119-t1x9gknd 10733 3 us -PRON- PRP cord-010119-t1x9gknd 10733 4 to to TO cord-010119-t1x9gknd 10733 5 adjust adjust VB cord-010119-t1x9gknd 10733 6 configuration configuration NN cord-010119-t1x9gknd 10733 7 settings setting NNS cord-010119-t1x9gknd 10733 8 when when WRB cord-010119-t1x9gknd 10733 9 appropriate appropriate JJ cord-010119-t1x9gknd 10733 10 to to TO cord-010119-t1x9gknd 10733 11 improve improve VB cord-010119-t1x9gknd 10733 12 the the DT cord-010119-t1x9gknd 10733 13 accuracy accuracy NN cord-010119-t1x9gknd 10733 14 of of IN cord-010119-t1x9gknd 10733 15 the the DT cord-010119-t1x9gknd 10733 16 yield yield NN cord-010119-t1x9gknd 10733 17 prediction prediction NN cord-010119-t1x9gknd 10733 18 . . . cord-010119-t1x9gknd 10734 1 Reports report NNS cord-010119-t1x9gknd 10734 2 by by IN cord-010119-t1x9gknd 10734 3 phlebotomist phlebotomist NN cord-010119-t1x9gknd 10734 4 were be VBD cord-010119-t1x9gknd 10734 5 utilized utilize VBN cord-010119-t1x9gknd 10734 6 for for IN cord-010119-t1x9gknd 10734 7 training training NN cord-010119-t1x9gknd 10734 8 on on IN cord-010119-t1x9gknd 10734 9 how how WRB cord-010119-t1x9gknd 10734 10 to to TO cord-010119-t1x9gknd 10734 11 optimize optimize VB cord-010119-t1x9gknd 10734 12 the the DT cord-010119-t1x9gknd 10734 13 donor donor NN cord-010119-t1x9gknd 10734 14 's 's POS cord-010119-t1x9gknd 10734 15 gift gift NN cord-010119-t1x9gknd 10734 16 to to TO cord-010119-t1x9gknd 10734 17 donate donate VB cord-010119-t1x9gknd 10734 18 an an DT cord-010119-t1x9gknd 10734 19 additional additional JJ cord-010119-t1x9gknd 10734 20 platelet platelet NN cord-010119-t1x9gknd 10734 21 or or CC cord-010119-t1x9gknd 10734 22 plasma plasma NN cord-010119-t1x9gknd 10734 23 product(s product(s NN cord-010119-t1x9gknd 10734 24 ) ) -RRB- cord-010119-t1x9gknd 10734 25 and and CC cord-010119-t1x9gknd 10734 26 increase increase VB cord-010119-t1x9gknd 10734 27 procedure procedure NN cord-010119-t1x9gknd 10734 28 success success NN cord-010119-t1x9gknd 10734 29 rate rate NN cord-010119-t1x9gknd 10734 30 . . . cord-010119-t1x9gknd 10735 1 Results/ Results/ . cord-010119-t1x9gknd 10736 1 Finding finding NN cord-010119-t1x9gknd 10736 2 : : : cord-010119-t1x9gknd 10737 1 The the DT cord-010119-t1x9gknd 10737 2 monthly monthly JJ cord-010119-t1x9gknd 10737 3 DXT DXT NNP cord-010119-t1x9gknd 10737 4 report report NN cord-010119-t1x9gknd 10737 5 analysis analysis NN cord-010119-t1x9gknd 10737 6 resulted result VBD cord-010119-t1x9gknd 10737 7 in in IN cord-010119-t1x9gknd 10737 8 device device NN cord-010119-t1x9gknd 10737 9 configuration configuration NN cord-010119-t1x9gknd 10737 10 improvements improvement NNS cord-010119-t1x9gknd 10737 11 , , , cord-010119-t1x9gknd 10737 12 phlebotomist phlebotomist NN cord-010119-t1x9gknd 10737 13 and and CC cord-010119-t1x9gknd 10737 14 center center NN cord-010119-t1x9gknd 10737 15 manager manager NN cord-010119-t1x9gknd 10737 16 accountability accountability NN cord-010119-t1x9gknd 10737 17 , , , cord-010119-t1x9gknd 10737 18 effective effective JJ cord-010119-t1x9gknd 10737 19 training training NN cord-010119-t1x9gknd 10737 20 , , , cord-010119-t1x9gknd 10737 21 and and CC cord-010119-t1x9gknd 10737 22 donation donation NN cord-010119-t1x9gknd 10737 23 optimization optimization NN cord-010119-t1x9gknd 10737 24 we -PRON- PRP cord-010119-t1x9gknd 10737 25 increased increase VBD cord-010119-t1x9gknd 10737 26 our -PRON- PRP$ cord-010119-t1x9gknd 10737 27 overall overall JJ cord-010119-t1x9gknd 10737 28 platelet platelet NN cord-010119-t1x9gknd 10737 29 split split NN cord-010119-t1x9gknd 10737 30 rate rate NN cord-010119-t1x9gknd 10737 31 15 15 CD cord-010119-t1x9gknd 10737 32 percent percent NN cord-010119-t1x9gknd 10737 33 and and CC cord-010119-t1x9gknd 10737 34 increased increase VBN cord-010119-t1x9gknd 10737 35 concurrent concurrent JJ cord-010119-t1x9gknd 10737 36 plasma plasma NN cord-010119-t1x9gknd 10737 37 collections collection NNS cord-010119-t1x9gknd 10737 38 by by IN cord-010119-t1x9gknd 10737 39 24 24 CD cord-010119-t1x9gknd 10737 40 percent percent NN cord-010119-t1x9gknd 10737 41 . . . cord-010119-t1x9gknd 10738 1 With with IN cord-010119-t1x9gknd 10738 2 utilization utilization NN cord-010119-t1x9gknd 10738 3 of of IN cord-010119-t1x9gknd 10738 4 the the DT cord-010119-t1x9gknd 10738 5 DXT dxt NN cord-010119-t1x9gknd 10738 6 reports report NNS cord-010119-t1x9gknd 10738 7 we -PRON- PRP cord-010119-t1x9gknd 10738 8 are be VBP cord-010119-t1x9gknd 10738 9 able able JJ cord-010119-t1x9gknd 10738 10 to to TO cord-010119-t1x9gknd 10738 11 take take VB cord-010119-t1x9gknd 10738 12 a a DT cord-010119-t1x9gknd 10738 13 proactive proactive JJ cord-010119-t1x9gknd 10738 14 approach approach NN cord-010119-t1x9gknd 10738 15 allowing allow VBG cord-010119-t1x9gknd 10738 16 us -PRON- PRP cord-010119-t1x9gknd 10738 17 to to TO cord-010119-t1x9gknd 10738 18 predict predict VB cord-010119-t1x9gknd 10738 19 product product NN cord-010119-t1x9gknd 10738 20 availability availability NN cord-010119-t1x9gknd 10738 21 , , , cord-010119-t1x9gknd 10738 22 with with IN cord-010119-t1x9gknd 10738 23 day day NN cord-010119-t1x9gknd 10738 24 to to IN cord-010119-t1x9gknd 10738 25 day day NN cord-010119-t1x9gknd 10738 26 variability variability NN cord-010119-t1x9gknd 10738 27 dropping drop VBG cord-010119-t1x9gknd 10738 28 no no DT cord-010119-t1x9gknd 10738 29 lower low JJR cord-010119-t1x9gknd 10738 30 than than IN cord-010119-t1x9gknd 10738 31 62 62 CD cord-010119-t1x9gknd 10738 32 percent percent NN cord-010119-t1x9gknd 10738 33 split split NN cord-010119-t1x9gknd 10738 34 . . . cord-010119-t1x9gknd 10739 1 Phlebotomist Phlebotomist NNP cord-010119-t1x9gknd 10739 2 QNS QNS NNP cord-010119-t1x9gknd 10739 3 rates rate NNS cord-010119-t1x9gknd 10739 4 were be VBD cord-010119-t1x9gknd 10739 5 easily easily RB cord-010119-t1x9gknd 10739 6 monitored monitor VBN cord-010119-t1x9gknd 10739 7 regularly regularly RB cord-010119-t1x9gknd 10739 8 ( ( -LRB- cord-010119-t1x9gknd 10739 9 daily daily JJ cord-010119-t1x9gknd 10739 10 , , , cord-010119-t1x9gknd 10739 11 weekly weekly JJ cord-010119-t1x9gknd 10739 12 monthly monthly NN cord-010119-t1x9gknd 10739 13 ) ) -RRB- cord-010119-t1x9gknd 10739 14 resulting result VBG cord-010119-t1x9gknd 10739 15 in in IN cord-010119-t1x9gknd 10739 16 a a DT cord-010119-t1x9gknd 10739 17 decrease decrease NN cord-010119-t1x9gknd 10739 18 in in IN cord-010119-t1x9gknd 10739 19 our -PRON- PRP$ cord-010119-t1x9gknd 10739 20 overall overall JJ cord-010119-t1x9gknd 10739 21 QNS QNS NNP cord-010119-t1x9gknd 10739 22 rate rate NN cord-010119-t1x9gknd 10739 23 to to IN cord-010119-t1x9gknd 10739 24 consistently consistently RB cord-010119-t1x9gknd 10739 25 below below IN cord-010119-t1x9gknd 10739 26 3 3 CD cord-010119-t1x9gknd 10739 27 percent percent NN cord-010119-t1x9gknd 10739 28 . . . cord-010119-t1x9gknd 10740 1 Conclusion conclusion NN cord-010119-t1x9gknd 10740 2 : : : cord-010119-t1x9gknd 10740 3 DXT DXT NNP cord-010119-t1x9gknd 10740 4 was be VBD cord-010119-t1x9gknd 10740 5 easy easy JJ cord-010119-t1x9gknd 10740 6 to to TO cord-010119-t1x9gknd 10740 7 implement implement VB cord-010119-t1x9gknd 10740 8 , , , cord-010119-t1x9gknd 10740 9 is be VBZ cord-010119-t1x9gknd 10740 10 very very RB cord-010119-t1x9gknd 10740 11 user user NN cord-010119-t1x9gknd 10740 12 friendly friendly JJ cord-010119-t1x9gknd 10740 13 and and CC cord-010119-t1x9gknd 10740 14 will will MD cord-010119-t1x9gknd 10740 15 continue continue VB cord-010119-t1x9gknd 10740 16 to to TO cord-010119-t1x9gknd 10740 17 help help VB cord-010119-t1x9gknd 10740 18 improve improve VB cord-010119-t1x9gknd 10740 19 our -PRON- PRP$ cord-010119-t1x9gknd 10740 20 platelet platelet NN cord-010119-t1x9gknd 10740 21 collection collection NN cord-010119-t1x9gknd 10740 22 and and CC cord-010119-t1x9gknd 10740 23 process process NN cord-010119-t1x9gknd 10740 24 improvements improvement NNS cord-010119-t1x9gknd 10740 25 between between IN cord-010119-t1x9gknd 10740 26 donor donor NN cord-010119-t1x9gknd 10740 27 centers center NNS cord-010119-t1x9gknd 10740 28 . . . cord-010119-t1x9gknd 10741 1 DXT DXT NNP cord-010119-t1x9gknd 10741 2 provides provide VBZ cord-010119-t1x9gknd 10741 3 invaluable invaluable JJ cord-010119-t1x9gknd 10741 4 tools tool NNS cord-010119-t1x9gknd 10741 5 for for IN cord-010119-t1x9gknd 10741 6 the the DT cord-010119-t1x9gknd 10741 7 Operational Operational NNP cord-010119-t1x9gknd 10741 8 Supervisors Supervisors NNPS cord-010119-t1x9gknd 10741 9 to to TO cord-010119-t1x9gknd 10741 10 monitor monitor VB cord-010119-t1x9gknd 10741 11 their -PRON- PRP$ cord-010119-t1x9gknd 10741 12 staff staff NN cord-010119-t1x9gknd 10741 13 and and CC cord-010119-t1x9gknd 10741 14 improve improve VB cord-010119-t1x9gknd 10741 15 productivity productivity NN cord-010119-t1x9gknd 10741 16 at at IN cord-010119-t1x9gknd 10741 17 their -PRON- PRP$ cord-010119-t1x9gknd 10741 18 multiple multiple JJ cord-010119-t1x9gknd 10741 19 sites site NNS cord-010119-t1x9gknd 10741 20 . . . cord-010119-t1x9gknd 10742 1 Next next JJ cord-010119-t1x9gknd 10742 2 step step NN cord-010119-t1x9gknd 10742 3 is be VBZ cord-010119-t1x9gknd 10742 4 to to TO cord-010119-t1x9gknd 10742 5 develop develop VB cord-010119-t1x9gknd 10742 6 the the DT cord-010119-t1x9gknd 10742 7 plan plan NN cord-010119-t1x9gknd 10742 8 for for IN cord-010119-t1x9gknd 10742 9 implementation implementation NN cord-010119-t1x9gknd 10742 10 of of IN cord-010119-t1x9gknd 10742 11 paperless paperless NN cord-010119-t1x9gknd 10742 12 documentation documentation NN cord-010119-t1x9gknd 10742 13 with with IN cord-010119-t1x9gknd 10742 14 DXT DXT NNP cord-010119-t1x9gknd 10742 15 and and CC cord-010119-t1x9gknd 10742 16 Healthcare Healthcare NNP cord-010119-t1x9gknd 10742 17 - - HYPH cord-010119-t1x9gknd 10742 18 ID ID NNP cord-010119-t1x9gknd 10742 19 . . . cord-010119-t1x9gknd 10743 1 The the DT cord-010119-t1x9gknd 10743 2 ability ability NN cord-010119-t1x9gknd 10743 3 to to TO cord-010119-t1x9gknd 10743 4 immediately immediately RB cord-010119-t1x9gknd 10743 5 review review VB cord-010119-t1x9gknd 10743 6 data datum NNS cord-010119-t1x9gknd 10743 7 directly directly RB cord-010119-t1x9gknd 10743 8 from from IN cord-010119-t1x9gknd 10743 9 Amicus Amicus NNP cord-010119-t1x9gknd 10743 10 was be VBD cord-010119-t1x9gknd 10743 11 key key JJ cord-010119-t1x9gknd 10743 12 in in IN cord-010119-t1x9gknd 10743 13 the the DT cord-010119-t1x9gknd 10743 14 productivity productivity NN cord-010119-t1x9gknd 10743 15 improvements improvement NNS cord-010119-t1x9gknd 10743 16 realized realize VBD cord-010119-t1x9gknd 10743 17 . . . cord-010119-t1x9gknd 10744 1 Evaluating evaluate VBG cord-010119-t1x9gknd 10744 2 the the DT cord-010119-t1x9gknd 10744 3 Impact Impact NNP cord-010119-t1x9gknd 10744 4 of of IN cord-010119-t1x9gknd 10744 5 a a DT cord-010119-t1x9gknd 10744 6 Background Background NNP cord-010119-t1x9gknd 10744 7 / / SYM cord-010119-t1x9gknd 10744 8 Case Case NNP cord-010119-t1x9gknd 10744 9 Studies Studies NNPS cord-010119-t1x9gknd 10744 10 : : : cord-010119-t1x9gknd 10744 11 As as IN cord-010119-t1x9gknd 10744 12 blood blood NN cord-010119-t1x9gknd 10744 13 and and CC cord-010119-t1x9gknd 10744 14 blood blood NN cord-010119-t1x9gknd 10744 15 products product NNS cord-010119-t1x9gknd 10744 16 are be VBP cord-010119-t1x9gknd 10744 17 limited limited JJ cord-010119-t1x9gknd 10744 18 and and CC cord-010119-t1x9gknd 10744 19 expensive expensive JJ cord-010119-t1x9gknd 10744 20 resources resource NNS cord-010119-t1x9gknd 10744 21 , , , cord-010119-t1x9gknd 10744 22 they -PRON- PRP cord-010119-t1x9gknd 10744 23 are be VBP cord-010119-t1x9gknd 10744 24 prescribed prescribe VBN cord-010119-t1x9gknd 10744 25 , , , cord-010119-t1x9gknd 10744 26 handled handle VBN cord-010119-t1x9gknd 10744 27 , , , cord-010119-t1x9gknd 10744 28 stored store VBN cord-010119-t1x9gknd 10744 29 and and CC cord-010119-t1x9gknd 10744 30 transfused transfuse VBN cord-010119-t1x9gknd 10744 31 according accord VBG cord-010119-t1x9gknd 10744 32 to to IN cord-010119-t1x9gknd 10744 33 hospital hospital NN cord-010119-t1x9gknd 10744 34 guidelines guideline NNS cord-010119-t1x9gknd 10744 35 established establish VBN cord-010119-t1x9gknd 10744 36 to to TO cord-010119-t1x9gknd 10744 37 ensure ensure VB cord-010119-t1x9gknd 10744 38 that that IN cord-010119-t1x9gknd 10744 39 the the DT cord-010119-t1x9gknd 10744 40 best good JJS cord-010119-t1x9gknd 10744 41 practice practice NN cord-010119-t1x9gknd 10744 42 standards standard NNS cord-010119-t1x9gknd 10744 43 are be VBP cord-010119-t1x9gknd 10744 44 maintained maintain VBN cord-010119-t1x9gknd 10744 45 for for IN cord-010119-t1x9gknd 10744 46 patient patient JJ cord-010119-t1x9gknd 10744 47 safety safety NN cord-010119-t1x9gknd 10744 48 . . . cord-010119-t1x9gknd 10745 1 It -PRON- PRP cord-010119-t1x9gknd 10745 2 is be VBZ cord-010119-t1x9gknd 10745 3 a a DT cord-010119-t1x9gknd 10745 4 prerequisite prerequisite NN cord-010119-t1x9gknd 10745 5 for for IN cord-010119-t1x9gknd 10745 6 all all DT cord-010119-t1x9gknd 10745 7 Registered register VBN cord-010119-t1x9gknd 10745 8 Nurses nurse NNS cord-010119-t1x9gknd 10745 9 ( ( -LRB- cord-010119-t1x9gknd 10745 10 RNs rn NNS cord-010119-t1x9gknd 10745 11 ) ) -RRB- cord-010119-t1x9gknd 10745 12 involved involve VBN cord-010119-t1x9gknd 10745 13 in in IN cord-010119-t1x9gknd 10745 14 blood blood NN cord-010119-t1x9gknd 10745 15 and and CC cord-010119-t1x9gknd 10745 16 blood blood NN cord-010119-t1x9gknd 10745 17 product product NN cord-010119-t1x9gknd 10745 18 administration administration NN cord-010119-t1x9gknd 10745 19 to to TO cord-010119-t1x9gknd 10745 20 possess possess VB cord-010119-t1x9gknd 10745 21 fundamental fundamental JJ cord-010119-t1x9gknd 10745 22 knowledge knowledge NN cord-010119-t1x9gknd 10745 23 of of IN cord-010119-t1x9gknd 10745 24 transfusion transfusion NN cord-010119-t1x9gknd 10745 25 practice practice NN cord-010119-t1x9gknd 10745 26 . . . cord-010119-t1x9gknd 10746 1 Aim aim VB cord-010119-t1x9gknd 10746 2 : : : cord-010119-t1x9gknd 10746 3 The the DT cord-010119-t1x9gknd 10746 4 aim aim NN cord-010119-t1x9gknd 10746 5 of of IN cord-010119-t1x9gknd 10746 6 this this DT cord-010119-t1x9gknd 10746 7 study study NN cord-010119-t1x9gknd 10746 8 is be VBZ cord-010119-t1x9gknd 10746 9 to to TO cord-010119-t1x9gknd 10746 10 evaluate evaluate VB cord-010119-t1x9gknd 10746 11 the the DT cord-010119-t1x9gknd 10746 12 impact impact NN cord-010119-t1x9gknd 10746 13 of of IN cord-010119-t1x9gknd 10746 14 a a DT cord-010119-t1x9gknd 10746 15 hospital hospital NN cord-010119-t1x9gknd 10746 16 - - HYPH cord-010119-t1x9gknd 10746 17 based base VBN cord-010119-t1x9gknd 10746 18 transfusion transfusion NN cord-010119-t1x9gknd 10746 19 practice practice NN cord-010119-t1x9gknd 10746 20 training training NN cord-010119-t1x9gknd 10746 21 program program NN cord-010119-t1x9gknd 10746 22 among among IN cord-010119-t1x9gknd 10746 23 registered register VBN cord-010119-t1x9gknd 10746 24 nurses nurse NNS cord-010119-t1x9gknd 10746 25 , , , cord-010119-t1x9gknd 10746 26 through through IN cord-010119-t1x9gknd 10746 27 administration administration NN cord-010119-t1x9gknd 10746 28 of of IN cord-010119-t1x9gknd 10746 29 a a DT cord-010119-t1x9gknd 10746 30 knowledge knowledge NN cord-010119-t1x9gknd 10746 31 - - HYPH cord-010119-t1x9gknd 10746 32 based base VBN cord-010119-t1x9gknd 10746 33 questionnaire questionnaire NN cord-010119-t1x9gknd 10746 34 before before IN cord-010119-t1x9gknd 10746 35 and and CC cord-010119-t1x9gknd 10746 36 after after IN cord-010119-t1x9gknd 10746 37 implementation implementation NN cord-010119-t1x9gknd 10746 38 of of IN cord-010119-t1x9gknd 10746 39 the the DT cord-010119-t1x9gknd 10746 40 program program NN cord-010119-t1x9gknd 10746 41 . . . cord-010119-t1x9gknd 10747 1 The the DT cord-010119-t1x9gknd 10747 2 results result NNS cord-010119-t1x9gknd 10747 3 gathered gather VBD cord-010119-t1x9gknd 10747 4 would would MD cord-010119-t1x9gknd 10747 5 identify identify VB cord-010119-t1x9gknd 10747 6 gaps gap NNS cord-010119-t1x9gknd 10747 7 in in IN cord-010119-t1x9gknd 10747 8 assimilation assimilation NN cord-010119-t1x9gknd 10747 9 of of IN cord-010119-t1x9gknd 10747 10 knowledge knowledge NN cord-010119-t1x9gknd 10747 11 and and CC cord-010119-t1x9gknd 10747 12 suggest suggest VBP cord-010119-t1x9gknd 10747 13 improvements improvement NNS cord-010119-t1x9gknd 10747 14 to to IN cord-010119-t1x9gknd 10747 15 the the DT cord-010119-t1x9gknd 10747 16 design design NN cord-010119-t1x9gknd 10747 17 and and CC cord-010119-t1x9gknd 10747 18 implementation implementation NN cord-010119-t1x9gknd 10747 19 of of IN cord-010119-t1x9gknd 10747 20 specific specific JJ cord-010119-t1x9gknd 10747 21 content content NN cord-010119-t1x9gknd 10747 22 in in IN cord-010119-t1x9gknd 10747 23 the the DT cord-010119-t1x9gknd 10747 24 nurse nurse NN cord-010119-t1x9gknd 10747 25 - - HYPH cord-010119-t1x9gknd 10747 26 led lead VBN cord-010119-t1x9gknd 10747 27 transfusion transfusion NN cord-010119-t1x9gknd 10747 28 training training NN cord-010119-t1x9gknd 10747 29 programme programme NN cord-010119-t1x9gknd 10747 30 . . . cord-010119-t1x9gknd 10748 1 Study Study NNP cord-010119-t1x9gknd 10748 2 Design Design NNP cord-010119-t1x9gknd 10748 3 / / SYM cord-010119-t1x9gknd 10748 4 Method method NN cord-010119-t1x9gknd 10748 5 : : : cord-010119-t1x9gknd 10749 1 All all DT cord-010119-t1x9gknd 10749 2 RNs rn NNS cord-010119-t1x9gknd 10749 3 from from IN cord-010119-t1x9gknd 10749 4 various various JJ cord-010119-t1x9gknd 10749 5 units unit NNS cord-010119-t1x9gknd 10749 6 and and CC cord-010119-t1x9gknd 10749 7 departments department NNS cord-010119-t1x9gknd 10749 8 were be VBD cord-010119-t1x9gknd 10749 9 invited invite VBN cord-010119-t1x9gknd 10749 10 to to TO cord-010119-t1x9gknd 10749 11 participate participate VB cord-010119-t1x9gknd 10749 12 in in IN cord-010119-t1x9gknd 10749 13 the the DT cord-010119-t1x9gknd 10749 14 blood blood NN cord-010119-t1x9gknd 10749 15 transfusion transfusion NN cord-010119-t1x9gknd 10749 16 knowledge knowledge NN cord-010119-t1x9gknd 10749 17 questionnaire questionnaire NN cord-010119-t1x9gknd 10749 18 in in IN cord-010119-t1x9gknd 10749 19 October October NNP cord-010119-t1x9gknd 10749 20 2015 2015 CD cord-010119-t1x9gknd 10749 21 . . . cord-010119-t1x9gknd 10750 1 After after IN cord-010119-t1x9gknd 10750 2 which which WDT cord-010119-t1x9gknd 10750 3 , , , cord-010119-t1x9gknd 10750 4 a a DT cord-010119-t1x9gknd 10750 5 formal formal JJ cord-010119-t1x9gknd 10750 6 transfusion transfusion NN cord-010119-t1x9gknd 10750 7 practice practice NN cord-010119-t1x9gknd 10750 8 training training NN cord-010119-t1x9gknd 10750 9 programme programme NN cord-010119-t1x9gknd 10750 10 was be VBD cord-010119-t1x9gknd 10750 11 introduced introduce VBN cord-010119-t1x9gknd 10750 12 , , , cord-010119-t1x9gknd 10750 13 consisting consist VBG cord-010119-t1x9gknd 10750 14 of of IN cord-010119-t1x9gknd 10750 15 an an DT cord-010119-t1x9gknd 10750 16 online online JJ cord-010119-t1x9gknd 10750 17 learning learning NN cord-010119-t1x9gknd 10750 18 platform platform NN cord-010119-t1x9gknd 10750 19 and and CC cord-010119-t1x9gknd 10750 20 in in IN cord-010119-t1x9gknd 10750 21 - - HYPH cord-010119-t1x9gknd 10750 22 service service NN cord-010119-t1x9gknd 10750 23 training training NN cord-010119-t1x9gknd 10750 24 sessions session NNS cord-010119-t1x9gknd 10750 25 . . . cord-010119-t1x9gknd 10751 1 The the DT cord-010119-t1x9gknd 10751 2 same same JJ cord-010119-t1x9gknd 10751 3 questionnaire questionnaire NN cord-010119-t1x9gknd 10751 4 was be VBD cord-010119-t1x9gknd 10751 5 administered administer VBN cord-010119-t1x9gknd 10751 6 to to IN cord-010119-t1x9gknd 10751 7 the the DT cord-010119-t1x9gknd 10751 8 RNs RNs NNPS cord-010119-t1x9gknd 10751 9 one one CD cord-010119-t1x9gknd 10751 10 year year NN cord-010119-t1x9gknd 10751 11 later later RB cord-010119-t1x9gknd 10751 12 in in IN cord-010119-t1x9gknd 10751 13 September September NNP cord-010119-t1x9gknd 10751 14 2016 2016 CD cord-010119-t1x9gknd 10751 15 for for IN cord-010119-t1x9gknd 10751 16 post post JJ cord-010119-t1x9gknd 10751 17 - - JJ cord-010119-t1x9gknd 10751 18 training training JJ cord-010119-t1x9gknd 10751 19 programme programme NN cord-010119-t1x9gknd 10751 20 evaluation evaluation NN cord-010119-t1x9gknd 10751 21 . . . cord-010119-t1x9gknd 10752 1 Individual individual JJ cord-010119-t1x9gknd 10752 2 item item NN cord-010119-t1x9gknd 10752 3 scores score NNS cord-010119-t1x9gknd 10752 4 and and CC cord-010119-t1x9gknd 10752 5 proportion proportion NN cord-010119-t1x9gknd 10752 6 of of IN cord-010119-t1x9gknd 10752 7 nurses nurse NNS cord-010119-t1x9gknd 10752 8 with with IN cord-010119-t1x9gknd 10752 9 perfect perfect JJ cord-010119-t1x9gknd 10752 10 scores score NNS cord-010119-t1x9gknd 10752 11 was be VBD cord-010119-t1x9gknd 10752 12 compared compare VBN cord-010119-t1x9gknd 10752 13 pre pre JJ cord-010119-t1x9gknd 10752 14 - - JJ cord-010119-t1x9gknd 10752 15 and and CC cord-010119-t1x9gknd 10752 16 post post NN cord-010119-t1x9gknd 10752 17 - - NN cord-010119-t1x9gknd 10752 18 implementation implementation NN cord-010119-t1x9gknd 10752 19 . . . cord-010119-t1x9gknd 10753 1 Results result NNS cord-010119-t1x9gknd 10753 2 / / SYM cord-010119-t1x9gknd 10753 3 Finding finding NN cord-010119-t1x9gknd 10753 4 : : : cord-010119-t1x9gknd 10754 1 In in IN cord-010119-t1x9gknd 10754 2 2015 2015 CD cord-010119-t1x9gknd 10754 3 and and CC cord-010119-t1x9gknd 10754 4 2016 2016 CD cord-010119-t1x9gknd 10754 5 , , , cord-010119-t1x9gknd 10754 6 a a DT cord-010119-t1x9gknd 10754 7 total total JJ cord-010119-t1x9gknd 10754 8 number number NN cord-010119-t1x9gknd 10754 9 1,097 1,097 CD cord-010119-t1x9gknd 10754 10 RNs rn NNS cord-010119-t1x9gknd 10754 11 and and CC cord-010119-t1x9gknd 10754 12 965 965 CD cord-010119-t1x9gknd 10754 13 RNs rn NNS cord-010119-t1x9gknd 10754 14 completed complete VBD cord-010119-t1x9gknd 10754 15 the the DT cord-010119-t1x9gknd 10754 16 questionnaires questionnaire NNS cord-010119-t1x9gknd 10754 17 , , , cord-010119-t1x9gknd 10754 18 giving give VBG cord-010119-t1x9gknd 10754 19 a a DT cord-010119-t1x9gknd 10754 20 response response NN cord-010119-t1x9gknd 10754 21 rate rate NN cord-010119-t1x9gknd 10754 22 of of IN cord-010119-t1x9gknd 10754 23 78.5 78.5 CD cord-010119-t1x9gknd 10754 24 % % NN cord-010119-t1x9gknd 10754 25 and and CC cord-010119-t1x9gknd 10754 26 67.4 67.4 CD cord-010119-t1x9gknd 10754 27 % % NN cord-010119-t1x9gknd 10754 28 respectively respectively RB cord-010119-t1x9gknd 10754 29 . . . cord-010119-t1x9gknd 10755 1 The the DT cord-010119-t1x9gknd 10755 2 overall overall JJ cord-010119-t1x9gknd 10755 3 mean mean JJ cord-010119-t1x9gknd 10755 4 score score NN cord-010119-t1x9gknd 10755 5 in in IN cord-010119-t1x9gknd 10755 6 2015 2015 CD cord-010119-t1x9gknd 10755 7 was be VBD cord-010119-t1x9gknd 10755 8 6.24 6.24 CD cord-010119-t1x9gknd 10755 9 points point NNS cord-010119-t1x9gknd 10755 10 ( ( -LRB- cord-010119-t1x9gknd 10755 11 range range NN cord-010119-t1x9gknd 10755 12 0 0 CD cord-010119-t1x9gknd 10755 13 to to IN cord-010119-t1x9gknd 10755 14 8) 8) NN cord-010119-t1x9gknd 10755 15 . . . cord-010119-t1x9gknd 10756 1 The the DT cord-010119-t1x9gknd 10756 2 mean mean JJ cord-010119-t1x9gknd 10756 3 score score NN cord-010119-t1x9gknd 10756 4 in in IN cord-010119-t1x9gknd 10756 5 2016 2016 CD cord-010119-t1x9gknd 10756 6 was be VBD cord-010119-t1x9gknd 10756 7 6.57 6.57 CD cord-010119-t1x9gknd 10756 8 points point NNS cord-010119-t1x9gknd 10756 9 ( ( -LRB- cord-010119-t1x9gknd 10756 10 range range NN cord-010119-t1x9gknd 10756 11 2 2 CD cord-010119-t1x9gknd 10756 12 to to IN cord-010119-t1x9gknd 10756 13 8) 8) NN cord-010119-t1x9gknd 10756 14 . . . cord-010119-t1x9gknd 10757 1 The the DT cord-010119-t1x9gknd 10757 2 percentage percentage NN cord-010119-t1x9gknd 10757 3 of of IN cord-010119-t1x9gknd 10757 4 RNs rn NNS cord-010119-t1x9gknd 10757 5 having have VBG cord-010119-t1x9gknd 10757 6 perfect perfect JJ cord-010119-t1x9gknd 10757 7 scores score NNS cord-010119-t1x9gknd 10757 8 of of IN cord-010119-t1x9gknd 10757 9 8 8 CD cord-010119-t1x9gknd 10757 10 increased increase VBD cord-010119-t1x9gknd 10757 11 from from IN cord-010119-t1x9gknd 10757 12 8.8 8.8 CD cord-010119-t1x9gknd 10757 13 % % NN cord-010119-t1x9gknd 10757 14 in in IN cord-010119-t1x9gknd 10757 15 2015 2015 CD cord-010119-t1x9gknd 10757 16 to to IN cord-010119-t1x9gknd 10757 17 20.5 20.5 CD cord-010119-t1x9gknd 10757 18 % % NN cord-010119-t1x9gknd 10757 19 in in IN cord-010119-t1x9gknd 10757 20 2016 2016 CD cord-010119-t1x9gknd 10757 21 . . . cord-010119-t1x9gknd 10758 1 Table table NN cord-010119-t1x9gknd 10758 2 I -PRON- PRP cord-010119-t1x9gknd 10758 3 below below RB cord-010119-t1x9gknd 10758 4 shows show VBZ cord-010119-t1x9gknd 10758 5 the the DT cord-010119-t1x9gknd 10758 6 results result NNS cord-010119-t1x9gknd 10758 7 for for IN cord-010119-t1x9gknd 10758 8 each each DT cord-010119-t1x9gknd 10758 9 question question NN cord-010119-t1x9gknd 10758 10 item item NN cord-010119-t1x9gknd 10758 11 . . . cord-010119-t1x9gknd 10759 1 The the DT cord-010119-t1x9gknd 10759 2 implementation implementation NN cord-010119-t1x9gknd 10759 3 of of IN cord-010119-t1x9gknd 10759 4 a a DT cord-010119-t1x9gknd 10759 5 hospital hospital NN cord-010119-t1x9gknd 10759 6 - - HYPH cord-010119-t1x9gknd 10759 7 based base VBN cord-010119-t1x9gknd 10759 8 , , , cord-010119-t1x9gknd 10759 9 nurse nurse NN cord-010119-t1x9gknd 10759 10 - - HYPH cord-010119-t1x9gknd 10759 11 led lead VBN cord-010119-t1x9gknd 10759 12 transfusion transfusion NN cord-010119-t1x9gknd 10759 13 practice practice NN cord-010119-t1x9gknd 10759 14 training training NN cord-010119-t1x9gknd 10759 15 programme programme NN cord-010119-t1x9gknd 10759 16 has have VBZ cord-010119-t1x9gknd 10759 17 led lead VBN cord-010119-t1x9gknd 10759 18 to to IN cord-010119-t1x9gknd 10759 19 encouraging encourage VBG cord-010119-t1x9gknd 10759 20 improvement improvement NN cord-010119-t1x9gknd 10759 21 in in IN cord-010119-t1x9gknd 10759 22 blood blood NN cord-010119-t1x9gknd 10759 23 transfusion transfusion NN cord-010119-t1x9gknd 10759 24 knowledge knowledge NN cord-010119-t1x9gknd 10759 25 amongst amongst IN cord-010119-t1x9gknd 10759 26 RNs rn NNS cord-010119-t1x9gknd 10759 27 . . . cord-010119-t1x9gknd 10760 1 Further further JJ cord-010119-t1x9gknd 10760 2 training training NN cord-010119-t1x9gknd 10760 3 may may MD cord-010119-t1x9gknd 10760 4 be be VB cord-010119-t1x9gknd 10760 5 needed need VBN cord-010119-t1x9gknd 10760 6 in in IN cord-010119-t1x9gknd 10760 7 the the DT cord-010119-t1x9gknd 10760 8 preparation preparation NN cord-010119-t1x9gknd 10760 9 of of IN cord-010119-t1x9gknd 10760 10 blood blood NN cord-010119-t1x9gknd 10760 11 sets set NNS cord-010119-t1x9gknd 10760 12 and and CC cord-010119-t1x9gknd 10760 13 management management NN cord-010119-t1x9gknd 10760 14 of of IN cord-010119-t1x9gknd 10760 15 fever fever NN cord-010119-t1x9gknd 10760 16 . . . cord-010119-t1x9gknd 10760 17 _SP cord-010119-t1x9gknd 10761 1 Background Background NNP cord-010119-t1x9gknd 10761 2 / / SYM cord-010119-t1x9gknd 10761 3 Case Case NNP cord-010119-t1x9gknd 10761 4 Studies Studies NNPS cord-010119-t1x9gknd 10761 5 : : : cord-010119-t1x9gknd 10761 6 Clinical clinical JJ cord-010119-t1x9gknd 10761 7 use use NN cord-010119-t1x9gknd 10761 8 of of IN cord-010119-t1x9gknd 10761 9 blood blood NN cord-010119-t1x9gknd 10761 10 has have VBZ cord-010119-t1x9gknd 10761 11 shown show VBN cord-010119-t1x9gknd 10761 12 to to TO cord-010119-t1x9gknd 10761 13 be be VB cord-010119-t1x9gknd 10761 14 the the DT cord-010119-t1x9gknd 10761 15 least least RBS cord-010119-t1x9gknd 10761 16 developed developed JJ cord-010119-t1x9gknd 10761 17 part part NN cord-010119-t1x9gknd 10761 18 in in IN cord-010119-t1x9gknd 10761 19 the the DT cord-010119-t1x9gknd 10761 20 vein vein NN cord-010119-t1x9gknd 10761 21 - - HYPH cord-010119-t1x9gknd 10761 22 to to IN cord-010119-t1x9gknd 10761 23 - - HYPH cord-010119-t1x9gknd 10761 24 vein vein NN cord-010119-t1x9gknd 10761 25 transfusion transfusion NN cord-010119-t1x9gknd 10761 26 chain chain NN cord-010119-t1x9gknd 10761 27 . . . cord-010119-t1x9gknd 10762 1 This this DT cord-010119-t1x9gknd 10762 2 global global JJ cord-010119-t1x9gknd 10762 3 survey survey NN cord-010119-t1x9gknd 10762 4 was be VBD cord-010119-t1x9gknd 10762 5 therefore therefore RB cord-010119-t1x9gknd 10762 6 carried carry VBN cord-010119-t1x9gknd 10762 7 out out RP cord-010119-t1x9gknd 10762 8 in in IN cord-010119-t1x9gknd 10762 9 order order NN cord-010119-t1x9gknd 10762 10 to to TO cord-010119-t1x9gknd 10762 11 investigate investigate VB cord-010119-t1x9gknd 10762 12 the the DT cord-010119-t1x9gknd 10762 13 level level NN cord-010119-t1x9gknd 10762 14 of of IN cord-010119-t1x9gknd 10762 15 awareness awareness NN cord-010119-t1x9gknd 10762 16 , , , cord-010119-t1x9gknd 10762 17 accessibility accessibility NN cord-010119-t1x9gknd 10762 18 and and CC cord-010119-t1x9gknd 10762 19 utilization utilization NN cord-010119-t1x9gknd 10762 20 of of IN cord-010119-t1x9gknd 10762 21 e e JJ cord-010119-t1x9gknd 10762 22 - - JJ cord-010119-t1x9gknd 10762 23 continuous continuous JJ cord-010119-t1x9gknd 10762 24 learning learning NN cord-010119-t1x9gknd 10762 25 and and CC cord-010119-t1x9gknd 10762 26 quality quality NN cord-010119-t1x9gknd 10762 27 of of IN cord-010119-t1x9gknd 10762 28 blood blood NN cord-010119-t1x9gknd 10762 29 use use NN cord-010119-t1x9gknd 10762 30 among among IN cord-010119-t1x9gknd 10762 31 blood blood NN cord-010119-t1x9gknd 10762 32 prescribing prescribe VBG cord-010119-t1x9gknd 10762 33 clinicians clinician NNS cord-010119-t1x9gknd 10762 34 and and CC cord-010119-t1x9gknd 10762 35 nurses nurse NNS cord-010119-t1x9gknd 10762 36 . . . cord-010119-t1x9gknd 10763 1 Study Study NNP cord-010119-t1x9gknd 10763 2 Design Design NNP cord-010119-t1x9gknd 10763 3 / / SYM cord-010119-t1x9gknd 10763 4 Methods method NNS cord-010119-t1x9gknd 10763 5 : : : cord-010119-t1x9gknd 10763 6 A a DT cord-010119-t1x9gknd 10763 7 descriptive descriptive JJ cord-010119-t1x9gknd 10763 8 ' ' `` cord-010119-t1x9gknd 10763 9 ex ex JJ cord-010119-t1x9gknd 10763 10 - - JJ cord-010119-t1x9gknd 10763 11 post post FW cord-010119-t1x9gknd 10763 12 facto facto FW cord-010119-t1x9gknd 10763 13 ' ' '' cord-010119-t1x9gknd 10763 14 survey survey NN cord-010119-t1x9gknd 10763 15 design design NN cord-010119-t1x9gknd 10763 16 was be VBD cord-010119-t1x9gknd 10763 17 used use VBN cord-010119-t1x9gknd 10763 18 ; ; : cord-010119-t1x9gknd 10763 19 264 264 CD cord-010119-t1x9gknd 10763 20 purposively purposively RB cord-010119-t1x9gknd 10763 21 selected select VBN cord-010119-t1x9gknd 10763 22 blood blood NN cord-010119-t1x9gknd 10763 23 prescribing prescribe VBG cord-010119-t1x9gknd 10763 24 clinicians clinician NNS cord-010119-t1x9gknd 10763 25 and and CC cord-010119-t1x9gknd 10763 26 nurses nurse NNS cord-010119-t1x9gknd 10763 27 from from IN cord-010119-t1x9gknd 10763 28 60 60 CD cord-010119-t1x9gknd 10763 29 hospitals hospital NNS cord-010119-t1x9gknd 10763 30 in in IN cord-010119-t1x9gknd 10763 31 13 13 CD cord-010119-t1x9gknd 10763 32 countries country NNS cord-010119-t1x9gknd 10763 33 of of IN cord-010119-t1x9gknd 10763 34 the the DT cord-010119-t1x9gknd 10763 35 4 4 CD cord-010119-t1x9gknd 10763 36 Human Human NNP cord-010119-t1x9gknd 10763 37 Development Development NNP cord-010119-t1x9gknd 10763 38 Index Index NNP cord-010119-t1x9gknd 10763 39 ( ( -LRB- cord-010119-t1x9gknd 10763 40 HDI HDI NNP cord-010119-t1x9gknd 10763 41 ) ) -RRB- cord-010119-t1x9gknd 10763 42 groups group NNS cord-010119-t1x9gknd 10763 43 ( ( -LRB- cord-010119-t1x9gknd 10763 44 Low Low NNP cord-010119-t1x9gknd 10763 45 , , , cord-010119-t1x9gknd 10763 46 Medium Medium NNP cord-010119-t1x9gknd 10763 47 , , , cord-010119-t1x9gknd 10763 48 High High NNP cord-010119-t1x9gknd 10763 49 , , , cord-010119-t1x9gknd 10763 50 and and CC cord-010119-t1x9gknd 10763 51 Very very RB cord-010119-t1x9gknd 10763 52 High high JJ cord-010119-t1x9gknd 10763 53 ) ) -RRB- cord-010119-t1x9gknd 10763 54 participated participate VBD cord-010119-t1x9gknd 10763 55 . . . cord-010119-t1x9gknd 10764 1 Three three CD cord-010119-t1x9gknd 10764 2 research research NN cord-010119-t1x9gknd 10764 3 questions question NNS cord-010119-t1x9gknd 10764 4 were be VBD cord-010119-t1x9gknd 10764 5 answered answer VBN cord-010119-t1x9gknd 10764 6 , , , cord-010119-t1x9gknd 10764 7 while while IN cord-010119-t1x9gknd 10764 8 seven seven CD cord-010119-t1x9gknd 10764 9 null null JJ cord-010119-t1x9gknd 10764 10 hypotheses hypothesis NNS cord-010119-t1x9gknd 10764 11 were be VBD cord-010119-t1x9gknd 10764 12 tested test VBN cord-010119-t1x9gknd 10764 13 at at IN cord-010119-t1x9gknd 10764 14 .05 .05 CD cord-010119-t1x9gknd 10764 15 level level NN cord-010119-t1x9gknd 10764 16 of of IN cord-010119-t1x9gknd 10764 17 significance significance NN cord-010119-t1x9gknd 10764 18 . . . cord-010119-t1x9gknd 10765 1 Descriptive descriptive JJ cord-010119-t1x9gknd 10765 2 statistical statistical JJ cord-010119-t1x9gknd 10765 3 tools tool NNS cord-010119-t1x9gknd 10765 4 ( ( -LRB- cord-010119-t1x9gknd 10765 5 frequency frequency NN cord-010119-t1x9gknd 10765 6 counts count NNS cord-010119-t1x9gknd 10765 7 and and CC cord-010119-t1x9gknd 10765 8 percentage percentage NN cord-010119-t1x9gknd 10765 9 ) ) -RRB- cord-010119-t1x9gknd 10765 10 were be VBD cord-010119-t1x9gknd 10765 11 used use VBN cord-010119-t1x9gknd 10765 12 to to TO cord-010119-t1x9gknd 10765 13 analyze analyze VB cord-010119-t1x9gknd 10765 14 the the DT cord-010119-t1x9gknd 10765 15 demographic demographic JJ cord-010119-t1x9gknd 10765 16 backgrounds background NNS cord-010119-t1x9gknd 10765 17 , , , cord-010119-t1x9gknd 10765 18 while while IN cord-010119-t1x9gknd 10765 19 inferential inferential JJ cord-010119-t1x9gknd 10765 20 statistics statistic NNS cord-010119-t1x9gknd 10765 21 -Pearson -pearson NN cord-010119-t1x9gknd 10765 22 Product product NN cord-010119-t1x9gknd 10765 23 - - HYPH cord-010119-t1x9gknd 10765 24 Moment Moment NNP cord-010119-t1x9gknd 10765 25 Correlation correlation NN cord-010119-t1x9gknd 10765 26 Coefficient Coefficient NNP cord-010119-t1x9gknd 10765 27 ( ( -LRB- cord-010119-t1x9gknd 10765 28 PPMC PPMC NNP cord-010119-t1x9gknd 10765 29 ) ) -RRB- cord-010119-t1x9gknd 10765 30 , , , cord-010119-t1x9gknd 10765 31 Analysis Analysis NNP cord-010119-t1x9gknd 10765 32 of of IN cord-010119-t1x9gknd 10765 33 Variance Variance NNP cord-010119-t1x9gknd 10765 34 ( ( -LRB- cord-010119-t1x9gknd 10765 35 ANOVA ANOVA NNP cord-010119-t1x9gknd 10765 36 ) ) -RRB- cord-010119-t1x9gknd 10765 37 , , , cord-010119-t1x9gknd 10765 38 were be VBD cord-010119-t1x9gknd 10765 39 used use VBN cord-010119-t1x9gknd 10765 40 to to TO cord-010119-t1x9gknd 10765 41 analyse analyse VB cord-010119-t1x9gknd 10765 42 the the DT cord-010119-t1x9gknd 10765 43 hypotheses hypothesis NNS cord-010119-t1x9gknd 10765 44 . . . cord-010119-t1x9gknd 10766 1 Results/ Results/ . cord-010119-t1x9gknd 10767 1 Findings finding NNS cord-010119-t1x9gknd 10767 2 : : : cord-010119-t1x9gknd 10767 3 Quality quality NN cord-010119-t1x9gknd 10767 4 of of IN cord-010119-t1x9gknd 10767 5 clinical clinical JJ cord-010119-t1x9gknd 10767 6 use use NN cord-010119-t1x9gknd 10767 7 of of IN cord-010119-t1x9gknd 10767 8 blood blood NN cord-010119-t1x9gknd 10767 9 was be VBD cord-010119-t1x9gknd 10767 10 positively positively RB cord-010119-t1x9gknd 10767 11 and and CC cord-010119-t1x9gknd 10767 12 significantly significantly RB cord-010119-t1x9gknd 10767 13 correlated correlate VBN cord-010119-t1x9gknd 10767 14 with with IN cord-010119-t1x9gknd 10767 15 levels level NNS cord-010119-t1x9gknd 10767 16 of of IN cord-010119-t1x9gknd 10767 17 awareness awareness NN cord-010119-t1x9gknd 10767 18 ( ( -LRB- cord-010119-t1x9gknd 10767 19 r5 r5 NNP cord-010119-t1x9gknd 10767 20 .137 .137 CD cord-010119-t1x9gknd 10767 21 ; ; : cord-010119-t1x9gknd 10767 22 p5.03 p5.03 NN cord-010119-t1x9gknd 10767 23 ; ; : cord-010119-t1x9gknd 10767 24 df5262 df5262 NN cord-010119-t1x9gknd 10767 25 ) ) -RRB- cord-010119-t1x9gknd 10767 26 and and CC cord-010119-t1x9gknd 10767 27 accessibility accessibility NN cord-010119-t1x9gknd 10767 28 ( ( -LRB- cord-010119-t1x9gknd 10767 29 r5.184 r5.184 NN cord-010119-t1x9gknd 10767 30 ; ; : cord-010119-t1x9gknd 10767 31 p5.01 p5.01 NN cord-010119-t1x9gknd 10767 32 ; ; : cord-010119-t1x9gknd 10767 33 df5262 df5262 ADD cord-010119-t1x9gknd 10767 34 ) ) -RRB- cord-010119-t1x9gknd 10767 35 to to IN cord-010119-t1x9gknd 10767 36 e e LS cord-010119-t1x9gknd 10767 37 - - JJ cord-010119-t1x9gknd 10767 38 continuous continuous JJ cord-010119-t1x9gknd 10767 39 learning learning NN cord-010119-t1x9gknd 10767 40 among among IN cord-010119-t1x9gknd 10767 41 blood blood NN cord-010119-t1x9gknd 10767 42 prescribing prescribe VBG cord-010119-t1x9gknd 10767 43 clinicians clinician NNS cord-010119-t1x9gknd 10767 44 / / SYM cord-010119-t1x9gknd 10767 45 nurses nurse NNS cord-010119-t1x9gknd 10767 46 . . . cord-010119-t1x9gknd 10768 1 There there EX cord-010119-t1x9gknd 10768 2 was be VBD cord-010119-t1x9gknd 10768 3 significant significant JJ cord-010119-t1x9gknd 10768 4 difference difference NN cord-010119-t1x9gknd 10768 5 in in IN cord-010119-t1x9gknd 10768 6 levels level NNS cord-010119-t1x9gknd 10768 7 of of IN cord-010119-t1x9gknd 10768 8 awareness awareness NN cord-010119-t1x9gknd 10768 9 [ [ -LRB- cord-010119-t1x9gknd 10768 10 F(3,260 f(3,260 NN cord-010119-t1x9gknd 10768 11 ) ) -RRB- cord-010119-t1x9gknd 10769 1 Conclusion conclusion NN cord-010119-t1x9gknd 10769 2 : : : cord-010119-t1x9gknd 10770 1 Today today NN cord-010119-t1x9gknd 10770 2 e e NN cord-010119-t1x9gknd 10770 3 - - JJ cord-010119-t1x9gknd 10770 4 continuous continuous JJ cord-010119-t1x9gknd 10770 5 learning learning NN cord-010119-t1x9gknd 10770 6 has have VBZ cord-010119-t1x9gknd 10770 7 become become VBN cord-010119-t1x9gknd 10770 8 a a DT cord-010119-t1x9gknd 10770 9 conditio conditio NN cord-010119-t1x9gknd 10770 10 sine sine FW cord-010119-t1x9gknd 10770 11 qua qua FW cord-010119-t1x9gknd 10770 12 non non FW cord-010119-t1x9gknd 10770 13 to to IN cord-010119-t1x9gknd 10770 14 effective effective JJ cord-010119-t1x9gknd 10770 15 and and CC cord-010119-t1x9gknd 10770 16 quality quality JJ cord-010119-t1x9gknd 10770 17 clinical clinical JJ cord-010119-t1x9gknd 10770 18 use use NN cord-010119-t1x9gknd 10770 19 of of IN cord-010119-t1x9gknd 10770 20 blood blood NN cord-010119-t1x9gknd 10770 21 . . . cord-010119-t1x9gknd 10771 1 The the DT cord-010119-t1x9gknd 10771 2 higher high JJR cord-010119-t1x9gknd 10771 3 the the DT cord-010119-t1x9gknd 10771 4 HDI hdi NN cord-010119-t1x9gknd 10771 5 level level NN cord-010119-t1x9gknd 10771 6 the the DT cord-010119-t1x9gknd 10771 7 better well JJR cord-010119-t1x9gknd 10771 8 the the DT cord-010119-t1x9gknd 10771 9 awareness awareness NN cord-010119-t1x9gknd 10771 10 , , , cord-010119-t1x9gknd 10771 11 accessibility accessibility NN cord-010119-t1x9gknd 10771 12 and and CC cord-010119-t1x9gknd 10771 13 utilization utilization NN cord-010119-t1x9gknd 10771 14 of of IN cord-010119-t1x9gknd 10771 15 continuous continuous JJ cord-010119-t1x9gknd 10771 16 education education NN cord-010119-t1x9gknd 10771 17 , , , cord-010119-t1x9gknd 10771 18 both both CC cord-010119-t1x9gknd 10771 19 through through IN cord-010119-t1x9gknd 10771 20 e e NN cord-010119-t1x9gknd 10771 21 - - NN cord-010119-t1x9gknd 10771 22 learning learning JJ cord-010119-t1x9gknd 10771 23 and and CC cord-010119-t1x9gknd 10771 24 conventional conventional JJ cord-010119-t1x9gknd 10771 25 programs program NNS cord-010119-t1x9gknd 10771 26 . . . cord-010119-t1x9gknd 10772 1 There there EX cord-010119-t1x9gknd 10772 2 is be VBZ cord-010119-t1x9gknd 10772 3 a a DT cord-010119-t1x9gknd 10772 4 better well JJR cord-010119-t1x9gknd 10772 5 awareness awareness NN cord-010119-t1x9gknd 10772 6 among among IN cord-010119-t1x9gknd 10772 7 clinicians clinician NNS cord-010119-t1x9gknd 10772 8 routinely routinely RB cord-010119-t1x9gknd 10772 9 prescribing prescribe VBG cord-010119-t1x9gknd 10772 10 blood blood NN cord-010119-t1x9gknd 10772 11 as as IN cord-010119-t1x9gknd 10772 12 compared compare VBN cord-010119-t1x9gknd 10772 13 to to IN cord-010119-t1x9gknd 10772 14 others other NNS cord-010119-t1x9gknd 10772 15 involved involve VBN cord-010119-t1x9gknd 10772 16 only only RB cord-010119-t1x9gknd 10772 17 incidentally incidentally RB cord-010119-t1x9gknd 10772 18 in in IN cord-010119-t1x9gknd 10772 19 blood blood NN cord-010119-t1x9gknd 10772 20 transfusion transfusion NN cord-010119-t1x9gknd 10772 21 . . . cord-010119-t1x9gknd 10773 1 Accessibility accessibility NN cord-010119-t1x9gknd 10773 2 of of IN cord-010119-t1x9gknd 10773 3 e e NN cord-010119-t1x9gknd 10773 4 - - NN cord-010119-t1x9gknd 10773 5 learning learning NN cord-010119-t1x9gknd 10773 6 depends depend VBZ cord-010119-t1x9gknd 10773 7 highly highly RB cord-010119-t1x9gknd 10773 8 on on IN cord-010119-t1x9gknd 10773 9 the the DT cord-010119-t1x9gknd 10773 10 presence presence NN cord-010119-t1x9gknd 10773 11 of of IN cord-010119-t1x9gknd 10773 12 a a DT cord-010119-t1x9gknd 10773 13 sustained sustained JJ cord-010119-t1x9gknd 10773 14 societal societal JJ cord-010119-t1x9gknd 10773 15 infrastructure infrastructure NN cord-010119-t1x9gknd 10773 16 which which WDT cord-010119-t1x9gknd 10773 17 is be VBZ cord-010119-t1x9gknd 10773 18 less less RBR cord-010119-t1x9gknd 10773 19 guaranteed guarantee VBN cord-010119-t1x9gknd 10773 20 in in IN cord-010119-t1x9gknd 10773 21 the the DT cord-010119-t1x9gknd 10773 22 Low Low NNP cord-010119-t1x9gknd 10773 23 and and CC cord-010119-t1x9gknd 10773 24 Medium Medium NNP cord-010119-t1x9gknd 10773 25 HDI HDI NNP cord-010119-t1x9gknd 10773 26 countries country NNS cord-010119-t1x9gknd 10773 27 ; ; : cord-010119-t1x9gknd 10773 28 reliable reliable JJ cord-010119-t1x9gknd 10773 29 power power NN cord-010119-t1x9gknd 10773 30 supply supply NN cord-010119-t1x9gknd 10773 31 , , , cord-010119-t1x9gknd 10773 32 maintenance maintenance NN cord-010119-t1x9gknd 10773 33 of of IN cord-010119-t1x9gknd 10773 34 hardware hardware NN cord-010119-t1x9gknd 10773 35 tools tool NNS cord-010119-t1x9gknd 10773 36 and and CC cord-010119-t1x9gknd 10773 37 updated update VBN cord-010119-t1x9gknd 10773 38 software software NN cord-010119-t1x9gknd 10773 39 programs program NNS cord-010119-t1x9gknd 10773 40 , , , cord-010119-t1x9gknd 10773 41 together together RB cord-010119-t1x9gknd 10773 42 with with IN cord-010119-t1x9gknd 10773 43 the the DT cord-010119-t1x9gknd 10773 44 necessary necessary JJ cord-010119-t1x9gknd 10773 45 knowledge knowledge NN cord-010119-t1x9gknd 10773 46 and and CC cord-010119-t1x9gknd 10773 47 skills skill NNS cord-010119-t1x9gknd 10773 48 of of IN cord-010119-t1x9gknd 10773 49 e e NN cord-010119-t1x9gknd 10773 50 - - NN cord-010119-t1x9gknd 10773 51 technology technology NN cord-010119-t1x9gknd 10773 52 are be VBP cord-010119-t1x9gknd 10773 53 prominent prominent JJ cord-010119-t1x9gknd 10773 54 factors factor NNS cord-010119-t1x9gknd 10773 55 . . . cord-010119-t1x9gknd 10774 1 The the DT cord-010119-t1x9gknd 10774 2 results result NNS cord-010119-t1x9gknd 10774 3 are be VBP cord-010119-t1x9gknd 10774 4 used use VBN cord-010119-t1x9gknd 10774 5 for for IN cord-010119-t1x9gknd 10774 6 policy policy NN cord-010119-t1x9gknd 10774 7 and and CC cord-010119-t1x9gknd 10774 8 strategy strategy NN cord-010119-t1x9gknd 10774 9 recommendations recommendation NNS cord-010119-t1x9gknd 10774 10 to to TO cord-010119-t1x9gknd 10774 11 improve improve VB cord-010119-t1x9gknd 10774 12 knowledge knowledge NN cord-010119-t1x9gknd 10774 13 and and CC cord-010119-t1x9gknd 10774 14 clinical clinical JJ cord-010119-t1x9gknd 10774 15 practice practice NN cord-010119-t1x9gknd 10774 16 through through IN cord-010119-t1x9gknd 10774 17 continuous continuous JJ cord-010119-t1x9gknd 10774 18 e e NN cord-010119-t1x9gknd 10774 19 - - HYPH cord-010119-t1x9gknd 10774 20 learning learn VBG cord-010119-t1x9gknd 10774 21 programs program NNS cord-010119-t1x9gknd 10774 22 eg eg VBP cord-010119-t1x9gknd 10774 23 , , , cord-010119-t1x9gknd 10774 24 starting start VBG cord-010119-t1x9gknd 10774 25 at at IN cord-010119-t1x9gknd 10774 26 undergraduate undergraduate JJ cord-010119-t1x9gknd 10774 27 medical medical JJ cord-010119-t1x9gknd 10774 28 and and CC cord-010119-t1x9gknd 10774 29 nursing nursing NN cord-010119-t1x9gknd 10774 30 schools school NNS cord-010119-t1x9gknd 10774 31 and and CC cord-010119-t1x9gknd 10774 32 continuing continue VBG cord-010119-t1x9gknd 10774 33 at at IN cord-010119-t1x9gknd 10774 34 postgraduate postgraduate JJ cord-010119-t1x9gknd 10774 35 vocational vocational JJ cord-010119-t1x9gknd 10774 36 medical medical JJ cord-010119-t1x9gknd 10774 37 specialization specialization NN cord-010119-t1x9gknd 10774 38 institutes institute NNS cord-010119-t1x9gknd 10774 39 , , , cord-010119-t1x9gknd 10774 40 principles principle NNS cord-010119-t1x9gknd 10774 41 of of IN cord-010119-t1x9gknd 10774 42 clinical clinical JJ cord-010119-t1x9gknd 10774 43 transfusion transfusion NN cord-010119-t1x9gknd 10774 44 practice practice NN cord-010119-t1x9gknd 10774 45 should should MD cord-010119-t1x9gknd 10774 46 be be VB cord-010119-t1x9gknd 10774 47 comprehensively comprehensively RB cord-010119-t1x9gknd 10774 48 included include VBN cord-010119-t1x9gknd 10774 49 through through IN cord-010119-t1x9gknd 10774 50 appropriate appropriate JJ cord-010119-t1x9gknd 10774 51 and and CC cord-010119-t1x9gknd 10774 52 timely timely JJ cord-010119-t1x9gknd 10774 53 curricula curriculum NNS cord-010119-t1x9gknd 10774 54 ; ; : cord-010119-t1x9gknd 10774 55 creation creation NN cord-010119-t1x9gknd 10774 56 of of IN cord-010119-t1x9gknd 10774 57 a a DT cord-010119-t1x9gknd 10774 58 technical technical JJ cord-010119-t1x9gknd 10774 59 climate climate NN cord-010119-t1x9gknd 10774 60 to to TO cord-010119-t1x9gknd 10774 61 guarantee guarantee VB cord-010119-t1x9gknd 10774 62 access access NN cord-010119-t1x9gknd 10774 63 to to IN cord-010119-t1x9gknd 10774 64 e e NN cord-010119-t1x9gknd 10774 65 - - JJ cord-010119-t1x9gknd 10774 66 learning learn VBG cord-010119-t1x9gknd 10774 67 courses course NNS cord-010119-t1x9gknd 10774 68 and and CC cord-010119-t1x9gknd 10774 69 materials material NNS cord-010119-t1x9gknd 10774 70 ; ; : cord-010119-t1x9gknd 10774 71 stimulation stimulation NN cord-010119-t1x9gknd 10774 72 of of IN cord-010119-t1x9gknd 10774 73 national national JJ cord-010119-t1x9gknd 10774 74 and and CC cord-010119-t1x9gknd 10774 75 international international JJ cord-010119-t1x9gknd 10774 76 exchange exchange NN cord-010119-t1x9gknd 10774 77 of of IN cord-010119-t1x9gknd 10774 78 e e LS cord-010119-t1x9gknd 10774 79 - - JJ cord-010119-t1x9gknd 10774 80 learning learn VBG cord-010119-t1x9gknd 10774 81 programs program NNS cord-010119-t1x9gknd 10774 82 focused focus VBN cord-010119-t1x9gknd 10774 83 on on IN cord-010119-t1x9gknd 10774 84 continuing continue VBG cord-010119-t1x9gknd 10774 85 education education NN cord-010119-t1x9gknd 10774 86 ; ; : cord-010119-t1x9gknd 10774 87 creation creation NN cord-010119-t1x9gknd 10774 88 of of IN cord-010119-t1x9gknd 10774 89 an an DT cord-010119-t1x9gknd 10774 90 e e NN cord-010119-t1x9gknd 10774 91 - - HYPH cord-010119-t1x9gknd 10774 92 learning learning JJ cord-010119-t1x9gknd 10774 93 mentoring mentoring NN cord-010119-t1x9gknd 10774 94 network network NN cord-010119-t1x9gknd 10774 95 through through IN cord-010119-t1x9gknd 10774 96 professional professional JJ cord-010119-t1x9gknd 10774 97 societies society NNS cord-010119-t1x9gknd 10774 98 , , , cord-010119-t1x9gknd 10774 99 associations association NNS cord-010119-t1x9gknd 10774 100 and and CC cord-010119-t1x9gknd 10774 101 education education NN cord-010119-t1x9gknd 10774 102 institutes institute NNS cord-010119-t1x9gknd 10774 103 . . . cord-010119-t1x9gknd 10775 1 Background Background NNP cord-010119-t1x9gknd 10775 2 / / SYM cord-010119-t1x9gknd 10775 3 Case Case NNP cord-010119-t1x9gknd 10775 4 Studies Studies NNPS cord-010119-t1x9gknd 10775 5 : : : cord-010119-t1x9gknd 10776 1 Transfusion transfusion NN cord-010119-t1x9gknd 10776 2 medicine medicine NN cord-010119-t1x9gknd 10776 3 ( ( -LRB- cord-010119-t1x9gknd 10776 4 TM TM NNP cord-010119-t1x9gknd 10776 5 ) ) -RRB- cord-010119-t1x9gknd 10776 6 didactic didactic JJ cord-010119-t1x9gknd 10776 7 teaching teaching NN cord-010119-t1x9gknd 10776 8 materials material NNS cord-010119-t1x9gknd 10776 9 for for IN cord-010119-t1x9gknd 10776 10 pathology pathology NN cord-010119-t1x9gknd 10776 11 residents resident NNS cord-010119-t1x9gknd 10776 12 are be VBP cord-010119-t1x9gknd 10776 13 not not RB cord-010119-t1x9gknd 10776 14 widely widely RB cord-010119-t1x9gknd 10776 15 available available JJ cord-010119-t1x9gknd 10776 16 to to TO cord-010119-t1x9gknd 10776 17 share share VB cord-010119-t1x9gknd 10776 18 among among IN cord-010119-t1x9gknd 10776 19 residency residency NN cord-010119-t1x9gknd 10776 20 training training NN cord-010119-t1x9gknd 10776 21 programs program NNS cord-010119-t1x9gknd 10776 22 . . . cord-010119-t1x9gknd 10777 1 The the DT cord-010119-t1x9gknd 10777 2 Advancing advance VBG cord-010119-t1x9gknd 10777 3 Blood blood NN cord-010119-t1x9gknd 10777 4 KnOwledge KnOwledge NNP cord-010119-t1x9gknd 10777 5 ( ( -LRB- cord-010119-t1x9gknd 10777 6 ABO ABO NNP cord-010119-t1x9gknd 10777 7 ) ) -RRB- cord-010119-t1x9gknd 10777 8 Leaders leader NNS cord-010119-t1x9gknd 10777 9 project project NN cord-010119-t1x9gknd 10777 10 is be VBZ cord-010119-t1x9gknd 10777 11 a a DT cord-010119-t1x9gknd 10777 12 novel novel JJ cord-010119-t1x9gknd 10777 13 approach approach NN cord-010119-t1x9gknd 10777 14 wherein wherein WRB cord-010119-t1x9gknd 10777 15 education education NN cord-010119-t1x9gknd 10777 16 materials material NNS cord-010119-t1x9gknd 10777 17 are be VBP cord-010119-t1x9gknd 10777 18 created create VBN cord-010119-t1x9gknd 10777 19 collaboratively collaboratively RB cord-010119-t1x9gknd 10777 20 through through IN cord-010119-t1x9gknd 10777 21 a a DT cord-010119-t1x9gknd 10777 22 community community NN cord-010119-t1x9gknd 10777 23 of of IN cord-010119-t1x9gknd 10777 24 practice practice NN cord-010119-t1x9gknd 10777 25 ( ( -LRB- cord-010119-t1x9gknd 10777 26 CoP cop NN cord-010119-t1x9gknd 10777 27 ) ) -RRB- cord-010119-t1x9gknd 10777 28 . . . cord-010119-t1x9gknd 10778 1 Educational educational JJ cord-010119-t1x9gknd 10778 2 theorist theorist NN cord-010119-t1x9gknd 10778 3 Etienne Etienne NNP cord-010119-t1x9gknd 10778 4 Wenger Wenger NNP cord-010119-t1x9gknd 10778 5 defined define VBD cord-010119-t1x9gknd 10778 6 CoPs CoPs NNP cord-010119-t1x9gknd 10778 7 as as IN cord-010119-t1x9gknd 10778 8 groups group NNS cord-010119-t1x9gknd 10778 9 of of IN cord-010119-t1x9gknd 10778 10 people people NNS cord-010119-t1x9gknd 10778 11 who who WP cord-010119-t1x9gknd 10778 12 share share VBP cord-010119-t1x9gknd 10778 13 a a DT cord-010119-t1x9gknd 10778 14 concern concern NN cord-010119-t1x9gknd 10778 15 or or CC cord-010119-t1x9gknd 10778 16 passion passion NN cord-010119-t1x9gknd 10778 17 for for IN cord-010119-t1x9gknd 10778 18 something something NN cord-010119-t1x9gknd 10778 19 they -PRON- PRP cord-010119-t1x9gknd 10778 20 do do VBP cord-010119-t1x9gknd 10778 21 and and CC cord-010119-t1x9gknd 10778 22 learn learn VB cord-010119-t1x9gknd 10778 23 how how WRB cord-010119-t1x9gknd 10778 24 to to TO cord-010119-t1x9gknd 10778 25 do do VB cord-010119-t1x9gknd 10778 26 it -PRON- PRP cord-010119-t1x9gknd 10778 27 better well RBR cord-010119-t1x9gknd 10778 28 as as IN cord-010119-t1x9gknd 10778 29 they -PRON- PRP cord-010119-t1x9gknd 10778 30 interact interact VBP cord-010119-t1x9gknd 10778 31 regularly regularly RB cord-010119-t1x9gknd 10778 32 . . . cord-010119-t1x9gknd 10779 1 Study Study NNP cord-010119-t1x9gknd 10779 2 Design Design NNP cord-010119-t1x9gknd 10779 3 / / SYM cord-010119-t1x9gknd 10779 4 Method method NN cord-010119-t1x9gknd 10779 5 : : : cord-010119-t1x9gknd 10780 1 As as IN cord-010119-t1x9gknd 10780 2 a a DT cord-010119-t1x9gknd 10780 3 pilot pilot NN cord-010119-t1x9gknd 10780 4 project project NN cord-010119-t1x9gknd 10780 5 , , , cord-010119-t1x9gknd 10780 6 7 7 CD cord-010119-t1x9gknd 10780 7 junior junior JJ cord-010119-t1x9gknd 10780 8 faculty faculty NN cord-010119-t1x9gknd 10780 9 co co NNS cord-010119-t1x9gknd 10780 10 - - NNS cord-010119-t1x9gknd 10780 11 investigators investigator NNS cord-010119-t1x9gknd 10780 12 from from IN cord-010119-t1x9gknd 10780 13 5 5 CD cord-010119-t1x9gknd 10780 14 west west NNP cord-010119-t1x9gknd 10780 15 coast coast NNP cord-010119-t1x9gknd 10780 16 institutions institution NNS cord-010119-t1x9gknd 10780 17 each each DT cord-010119-t1x9gknd 10780 18 had have VBD cord-010119-t1x9gknd 10780 19 2 2 CD cord-010119-t1x9gknd 10780 20 months month NNS cord-010119-t1x9gknd 10780 21 to to TO cord-010119-t1x9gknd 10780 22 create create VB cord-010119-t1x9gknd 10780 23 a a DT cord-010119-t1x9gknd 10780 24 30 30 CD cord-010119-t1x9gknd 10780 25 minute minute NN cord-010119-t1x9gknd 10780 26 PowerPoint PowerPoint NNP cord-010119-t1x9gknd 10780 27 presentation presentation NN cord-010119-t1x9gknd 10780 28 on on IN cord-010119-t1x9gknd 10780 29 a a DT cord-010119-t1x9gknd 10780 30 fundamental fundamental JJ cord-010119-t1x9gknd 10780 31 TM TM NNP cord-010119-t1x9gknd 10780 32 topic topic NN cord-010119-t1x9gknd 10780 33 , , , cord-010119-t1x9gknd 10780 34 after after IN cord-010119-t1x9gknd 10780 35 which which WDT cord-010119-t1x9gknd 10780 36 2 2 CD cord-010119-t1x9gknd 10780 37 other other JJ cord-010119-t1x9gknd 10780 38 members member NNS cord-010119-t1x9gknd 10780 39 had have VBD cord-010119-t1x9gknd 10780 40 2 2 CD cord-010119-t1x9gknd 10780 41 months month NNS cord-010119-t1x9gknd 10780 42 to to TO cord-010119-t1x9gknd 10780 43 review review VB cord-010119-t1x9gknd 10780 44 and and CC cord-010119-t1x9gknd 10780 45 edit edit VB cord-010119-t1x9gknd 10780 46 . . . cord-010119-t1x9gknd 10781 1 Therefore therefore RB cord-010119-t1x9gknd 10781 2 , , , cord-010119-t1x9gknd 10781 3 each each DT cord-010119-t1x9gknd 10781 4 member member NN cord-010119-t1x9gknd 10781 5 created create VBD cord-010119-t1x9gknd 10781 6 1 1 CD cord-010119-t1x9gknd 10781 7 and and CC cord-010119-t1x9gknd 10781 8 reviewed review VBD cord-010119-t1x9gknd 10781 9 2 2 CD cord-010119-t1x9gknd 10781 10 presentations presentation NNS cord-010119-t1x9gknd 10781 11 ( ( -LRB- cord-010119-t1x9gknd 10781 12 three three CD cord-010119-t1x9gknd 10781 13 total total JJ cord-010119-t1x9gknd 10781 14 steps step NNS cord-010119-t1x9gknd 10781 15 ) ) -RRB- cord-010119-t1x9gknd 10781 16 . . . cord-010119-t1x9gknd 10782 1 During during IN cord-010119-t1x9gknd 10782 2 each each DT cord-010119-t1x9gknd 10782 3 step step NN cord-010119-t1x9gknd 10782 4 , , , cord-010119-t1x9gknd 10782 5 members member NNS cord-010119-t1x9gknd 10782 6 wrote write VBD cord-010119-t1x9gknd 10782 7 2 2 CD cord-010119-t1x9gknd 10782 8 multiple multiple JJ cord-010119-t1x9gknd 10782 9 - - HYPH cord-010119-t1x9gknd 10782 10 choice choice NN cord-010119-t1x9gknd 10782 11 questions question NNS cord-010119-t1x9gknd 10782 12 for for IN cord-010119-t1x9gknd 10782 13 those those DT cord-010119-t1x9gknd 10782 14 particular particular JJ cord-010119-t1x9gknd 10782 15 topics topic NNS cord-010119-t1x9gknd 10782 16 . . . cord-010119-t1x9gknd 10783 1 In in IN cord-010119-t1x9gknd 10783 2 the the DT cord-010119-t1x9gknd 10783 3 end end NN cord-010119-t1x9gknd 10783 4 , , , cord-010119-t1x9gknd 10783 5 each each DT cord-010119-t1x9gknd 10783 6 topic topic NN cord-010119-t1x9gknd 10783 7 would would MD cord-010119-t1x9gknd 10783 8 have have VB cord-010119-t1x9gknd 10783 9 6 6 CD cord-010119-t1x9gknd 10783 10 quiz quiz NN cord-010119-t1x9gknd 10783 11 questions question NNS cord-010119-t1x9gknd 10783 12 to to TO cord-010119-t1x9gknd 10783 13 assess assess VB cord-010119-t1x9gknd 10783 14 learning learn VBG cord-010119-t1x9gknd 10783 15 . . . cord-010119-t1x9gknd 10784 1 At at IN cord-010119-t1x9gknd 10784 2 completion completion NN cord-010119-t1x9gknd 10784 3 , , , cord-010119-t1x9gknd 10784 4 7 7 CD cord-010119-t1x9gknd 10784 5 evidence evidence NN cord-010119-t1x9gknd 10784 6 - - HYPH cord-010119-t1x9gknd 10784 7 based base VBN cord-010119-t1x9gknd 10784 8 , , , cord-010119-t1x9gknd 10784 9 peer peer NN cord-010119-t1x9gknd 10784 10 reviewed review VBN cord-010119-t1x9gknd 10784 11 presentations presentation NNS cord-010119-t1x9gknd 10784 12 would would MD cord-010119-t1x9gknd 10784 13 be be VB cord-010119-t1x9gknd 10784 14 available available JJ cord-010119-t1x9gknd 10784 15 for for IN cord-010119-t1x9gknd 10784 16 all all DT cord-010119-t1x9gknd 10784 17 members member NNS cord-010119-t1x9gknd 10784 18 to to TO cord-010119-t1x9gknd 10784 19 use use VB cord-010119-t1x9gknd 10784 20 for for IN cord-010119-t1x9gknd 10784 21 teaching teach VBG cord-010119-t1x9gknd 10784 22 pathology pathology NN cord-010119-t1x9gknd 10784 23 residents resident NNS cord-010119-t1x9gknd 10784 24 . . . cord-010119-t1x9gknd 10785 1 Three three CD cord-010119-t1x9gknd 10785 2 methods method NNS cord-010119-t1x9gknd 10785 3 were be VBD cord-010119-t1x9gknd 10785 4 planned plan VBN cord-010119-t1x9gknd 10785 5 to to TO cord-010119-t1x9gknd 10785 6 measure measure VB cord-010119-t1x9gknd 10785 7 effectiveness effectiveness NN cord-010119-t1x9gknd 10785 8 of of IN cord-010119-t1x9gknd 10785 9 these these DT cord-010119-t1x9gknd 10785 10 materials material NNS cord-010119-t1x9gknd 10785 11 : : : cord-010119-t1x9gknd 10785 12 1 1 LS cord-010119-t1x9gknd 10785 13 ) ) -RRB- cord-010119-t1x9gknd 10785 14 Pre pre VB cord-010119-t1x9gknd 10785 15 and and CC cord-010119-t1x9gknd 10785 16 postlecture postlecture VB cord-010119-t1x9gknd 10785 17 ABO ABO NNP cord-010119-t1x9gknd 10785 18 Leaders leader NNS cord-010119-t1x9gknd 10785 19 exam exam NN cord-010119-t1x9gknd 10785 20 using use VBG cord-010119-t1x9gknd 10785 21 the the DT cord-010119-t1x9gknd 10785 22 questions question NNS cord-010119-t1x9gknd 10785 23 made make VBN cord-010119-t1x9gknd 10785 24 for for IN cord-010119-t1x9gknd 10785 25 each each DT cord-010119-t1x9gknd 10785 26 topic topic NN cord-010119-t1x9gknd 10785 27 to to TO cord-010119-t1x9gknd 10785 28 assess assess VB cord-010119-t1x9gknd 10785 29 learning learning NN cord-010119-t1x9gknd 10785 30 ; ; : cord-010119-t1x9gknd 10785 31 2 2 LS cord-010119-t1x9gknd 10785 32 ) ) -RRB- cord-010119-t1x9gknd 10785 33 Pre pre VB cord-010119-t1x9gknd 10785 34 and and CC cord-010119-t1x9gknd 10785 35 post post JJ cord-010119-t1x9gknd 10785 36 - - JJ cord-010119-t1x9gknd 10785 37 lecture lecture JJ cord-010119-t1x9gknd 10785 38 20 20 CD cord-010119-t1x9gknd 10785 39 question question NN cord-010119-t1x9gknd 10785 40 validated validate VBN cord-010119-t1x9gknd 10785 41 examination examination NN cord-010119-t1x9gknd 10785 42 ( ( -LRB- cord-010119-t1x9gknd 10785 43 BEST BEST NNP cord-010119-t1x9gknd 10785 44 Collaborative Collaborative NNP cord-010119-t1x9gknd 10785 45 ) ) -RRB- cord-010119-t1x9gknd 10785 46 to to TO cord-010119-t1x9gknd 10785 47 assess assess VB cord-010119-t1x9gknd 10785 48 learning learning NN cord-010119-t1x9gknd 10785 49 ; ; : cord-010119-t1x9gknd 10785 50 3 3 CD cord-010119-t1x9gknd 10785 51 ) ) -RRB- cord-010119-t1x9gknd 10785 52 Resident Resident NNP cord-010119-t1x9gknd 10785 53 In in IN cord-010119-t1x9gknd 10785 54 - - HYPH cord-010119-t1x9gknd 10785 55 service service NN cord-010119-t1x9gknd 10785 56 examination examination NN cord-010119-t1x9gknd 10785 57 trends trend NNS cord-010119-t1x9gknd 10785 58 specific specific JJ cord-010119-t1x9gknd 10785 59 to to IN cord-010119-t1x9gknd 10785 60 TM TM NNP cord-010119-t1x9gknd 10785 61 . . . cord-010119-t1x9gknd 10786 1 Results/ Results/ . cord-010119-t1x9gknd 10787 1 Finding finding NN cord-010119-t1x9gknd 10787 2 : : : cord-010119-t1x9gknd 10788 1 Six six CD cord-010119-t1x9gknd 10788 2 presentations presentation NNS cord-010119-t1x9gknd 10788 3 were be VBD cord-010119-t1x9gknd 10788 4 developed develop VBN cord-010119-t1x9gknd 10788 5 as as IN cord-010119-t1x9gknd 10788 6 6 6 CD cord-010119-t1x9gknd 10788 7 of of IN cord-010119-t1x9gknd 10788 8 the the DT cord-010119-t1x9gknd 10788 9 7 7 CD cord-010119-t1x9gknd 10788 10 ABO ABO NNP cord-010119-t1x9gknd 10788 11 Leaders Leaders NNPS cord-010119-t1x9gknd 10788 12 members member NNS cord-010119-t1x9gknd 10788 13 continue continue VBP cord-010119-t1x9gknd 10788 14 to to TO cord-010119-t1x9gknd 10788 15 participate participate VB cord-010119-t1x9gknd 10788 16 in in IN cord-010119-t1x9gknd 10788 17 this this DT cord-010119-t1x9gknd 10788 18 CoP cop NN cord-010119-t1x9gknd 10788 19 for for IN cord-010119-t1x9gknd 10788 20 TM TM NNP cord-010119-t1x9gknd 10788 21 education education NN cord-010119-t1x9gknd 10788 22 . . . cord-010119-t1x9gknd 10789 1 ABO ABO NNP cord-010119-t1x9gknd 10789 2 Leaders leader NNS cord-010119-t1x9gknd 10789 3 and and CC cord-010119-t1x9gknd 10789 4 BEST best JJ cord-010119-t1x9gknd 10789 5 pre pre JJ cord-010119-t1x9gknd 10789 6 - - JJ cord-010119-t1x9gknd 10789 7 test test JJ cord-010119-t1x9gknd 10789 8 results result NNS cord-010119-t1x9gknd 10789 9 are be VBP cord-010119-t1x9gknd 10789 10 shown show VBN cord-010119-t1x9gknd 10789 11 in in IN cord-010119-t1x9gknd 10789 12 tables table NNS cord-010119-t1x9gknd 10789 13 1 1 CD cord-010119-t1x9gknd 10789 14 and and CC cord-010119-t1x9gknd 10789 15 2 2 CD cord-010119-t1x9gknd 10789 16 . . . cord-010119-t1x9gknd 10790 1 ABO ABO NNP cord-010119-t1x9gknd 10790 2 Leaders leader NNS cord-010119-t1x9gknd 10790 3 pre pre VBP cord-010119-t1x9gknd 10790 4 - - JJ cord-010119-t1x9gknd 10790 5 test test JJ cord-010119-t1x9gknd 10790 6 data datum NNS cord-010119-t1x9gknd 10790 7 could could MD cord-010119-t1x9gknd 10790 8 not not RB cord-010119-t1x9gknd 10790 9 be be VB cord-010119-t1x9gknd 10790 10 obtained obtain VBN cord-010119-t1x9gknd 10790 11 for for IN cord-010119-t1x9gknd 10790 12 institution institution NN cord-010119-t1x9gknd 10790 13 B b NN cord-010119-t1x9gknd 10790 14 , , , cord-010119-t1x9gknd 10790 15 and and CC cord-010119-t1x9gknd 10790 16 3 3 CD cord-010119-t1x9gknd 10790 17 trainees trainee NNS cord-010119-t1x9gknd 10790 18 declined decline VBD cord-010119-t1x9gknd 10790 19 to to TO cord-010119-t1x9gknd 10790 20 participate participate VB cord-010119-t1x9gknd 10790 21 in in IN cord-010119-t1x9gknd 10790 22 the the DT cord-010119-t1x9gknd 10790 23 examinations examination NNS cord-010119-t1x9gknd 10790 24 at at IN cord-010119-t1x9gknd 10790 25 institution institution NN cord-010119-t1x9gknd 10790 26 A. a. NN cord-010119-t1x9gknd 10790 27 Challenges challenge NNS cord-010119-t1x9gknd 10790 28 experienced experience VBN cord-010119-t1x9gknd 10790 29 by by IN cord-010119-t1x9gknd 10790 30 the the DT cord-010119-t1x9gknd 10790 31 CoP cop NN cord-010119-t1x9gknd 10790 32 have have VBP cord-010119-t1x9gknd 10790 33 included include VBN cord-010119-t1x9gknd 10790 34 heterogeneity heterogeneity NN cord-010119-t1x9gknd 10790 35 between between IN cord-010119-t1x9gknd 10790 36 institutionsÕ institutionsÕ NNP cord-010119-t1x9gknd 10790 37 resident resident JJ cord-010119-t1x9gknd 10790 38 schedules schedule NNS cord-010119-t1x9gknd 10790 39 , , , cord-010119-t1x9gknd 10790 40 balancing balance VBG cord-010119-t1x9gknd 10790 41 time time NN cord-010119-t1x9gknd 10790 42 dedicated dedicated JJ cord-010119-t1x9gknd 10790 43 to to IN cord-010119-t1x9gknd 10790 44 the the DT cord-010119-t1x9gknd 10790 45 group group NN cord-010119-t1x9gknd 10790 46 given give VBN cord-010119-t1x9gknd 10790 47 busy busy JJ cord-010119-t1x9gknd 10790 48 schedules schedule NNS cord-010119-t1x9gknd 10790 49 , , , cord-010119-t1x9gknd 10790 50 and and CC cord-010119-t1x9gknd 10790 51 difficulty difficulty NN cord-010119-t1x9gknd 10790 52 in in IN cord-010119-t1x9gknd 10790 53 giving give VBG cord-010119-t1x9gknd 10790 54 all all DT cord-010119-t1x9gknd 10790 55 6 6 CD cord-010119-t1x9gknd 10790 56 presentations presentation NNS cord-010119-t1x9gknd 10790 57 during during IN cord-010119-t1x9gknd 10790 58 the the DT cord-010119-t1x9gknd 10790 59 defined define VBN cord-010119-t1x9gknd 10790 60 institution institution NN cord-010119-t1x9gknd 10790 61 - - HYPH cord-010119-t1x9gknd 10790 62 specific specific JJ cord-010119-t1x9gknd 10790 63 teaching teaching NN cord-010119-t1x9gknd 10790 64 period period NN cord-010119-t1x9gknd 10790 65 . . . cord-010119-t1x9gknd 10791 1 Post post JJ cord-010119-t1x9gknd 10791 2 - - JJ cord-010119-t1x9gknd 10791 3 test test NN cord-010119-t1x9gknd 10791 4 results result NNS cord-010119-t1x9gknd 10791 5 will will MD cord-010119-t1x9gknd 10791 6 be be VB cord-010119-t1x9gknd 10791 7 included include VBN cord-010119-t1x9gknd 10791 8 when when WRB cord-010119-t1x9gknd 10791 9 assessments assessment NNS cord-010119-t1x9gknd 10791 10 are be VBP cord-010119-t1x9gknd 10791 11 complete complete JJ cord-010119-t1x9gknd 10791 12 . . . cord-010119-t1x9gknd 10792 1 Conclusion conclusion NN cord-010119-t1x9gknd 10792 2 : : : cord-010119-t1x9gknd 10793 1 Despite despite IN cord-010119-t1x9gknd 10793 2 logistical logistical JJ cord-010119-t1x9gknd 10793 3 and and CC cord-010119-t1x9gknd 10793 4 organizational organizational JJ cord-010119-t1x9gknd 10793 5 challenges challenge NNS cord-010119-t1x9gknd 10793 6 , , , cord-010119-t1x9gknd 10793 7 it -PRON- PRP cord-010119-t1x9gknd 10793 8 is be VBZ cord-010119-t1x9gknd 10793 9 feasible feasible JJ cord-010119-t1x9gknd 10793 10 to to TO cord-010119-t1x9gknd 10793 11 create create VB cord-010119-t1x9gknd 10793 12 a a DT cord-010119-t1x9gknd 10793 13 multicenter multicenter JJ cord-010119-t1x9gknd 10793 14 CoP cop NN cord-010119-t1x9gknd 10793 15 for for IN cord-010119-t1x9gknd 10793 16 TM TM NNP cord-010119-t1x9gknd 10793 17 education education NN cord-010119-t1x9gknd 10793 18 . . . cord-010119-t1x9gknd 10794 1 The the DT cord-010119-t1x9gknd 10794 2 impact impact NN cord-010119-t1x9gknd 10794 3 of of IN cord-010119-t1x9gknd 10794 4 such such PDT cord-010119-t1x9gknd 10794 5 a a DT cord-010119-t1x9gknd 10794 6 group group NN cord-010119-t1x9gknd 10794 7 on on IN cord-010119-t1x9gknd 10794 8 resident resident JJ cord-010119-t1x9gknd 10794 9 learning learning NN cord-010119-t1x9gknd 10794 10 will will MD cord-010119-t1x9gknd 10794 11 be be VB cord-010119-t1x9gknd 10794 12 assessed assess VBN cord-010119-t1x9gknd 10794 13 and and CC cord-010119-t1x9gknd 10794 14 plans plan NNS cord-010119-t1x9gknd 10794 15 for for IN cord-010119-t1x9gknd 10794 16 growth growth NN cord-010119-t1x9gknd 10794 17 will will MD cord-010119-t1x9gknd 10794 18 be be VB cord-010119-t1x9gknd 10794 19 evaluated evaluate VBN cord-010119-t1x9gknd 10794 20 . . . cord-010119-t1x9gknd 10795 1 Background Background NNP cord-010119-t1x9gknd 10795 2 / / SYM cord-010119-t1x9gknd 10795 3 Case Case NNP cord-010119-t1x9gknd 10795 4 Studies Studies NNPS cord-010119-t1x9gknd 10795 5 : : : cord-010119-t1x9gknd 10796 1 The the DT cord-010119-t1x9gknd 10796 2 traditional traditional JJ cord-010119-t1x9gknd 10796 3 educational educational JJ cord-010119-t1x9gknd 10796 4 curriculum curriculum NN cord-010119-t1x9gknd 10796 5 for for IN cord-010119-t1x9gknd 10796 6 the the DT cord-010119-t1x9gknd 10796 7 pathology pathology NN cord-010119-t1x9gknd 10796 8 residency residency NN cord-010119-t1x9gknd 10796 9 program program NN cord-010119-t1x9gknd 10796 10 is be VBZ cord-010119-t1x9gknd 10796 11 primarily primarily RB cord-010119-t1x9gknd 10796 12 based base VBN cord-010119-t1x9gknd 10796 13 on on IN cord-010119-t1x9gknd 10796 14 didactic didactic JJ cord-010119-t1x9gknd 10796 15 lectures lecture NNS cord-010119-t1x9gknd 10796 16 , , , cord-010119-t1x9gknd 10796 17 casebased casebased JJ cord-010119-t1x9gknd 10796 18 presentations presentation NNS cord-010119-t1x9gknd 10796 19 , , , cord-010119-t1x9gknd 10796 20 and and CC cord-010119-t1x9gknd 10796 21 discussion discussion NN cord-010119-t1x9gknd 10796 22 of of IN cord-010119-t1x9gknd 10796 23 on on IN cord-010119-t1x9gknd 10796 24 - - HYPH cord-010119-t1x9gknd 10796 25 call call NN cord-010119-t1x9gknd 10796 26 cases case NNS cord-010119-t1x9gknd 10796 27 . . . cord-010119-t1x9gknd 10797 1 The the DT cord-010119-t1x9gknd 10797 2 use use NN cord-010119-t1x9gknd 10797 3 of of IN cord-010119-t1x9gknd 10797 4 dramatic dramatic JJ cord-010119-t1x9gknd 10797 5 vignettes vignette NNS cord-010119-t1x9gknd 10797 6 has have VBZ cord-010119-t1x9gknd 10797 7 proven prove VBN cord-010119-t1x9gknd 10797 8 to to TO cord-010119-t1x9gknd 10797 9 be be VB cord-010119-t1x9gknd 10797 10 an an DT cord-010119-t1x9gknd 10797 11 effective effective JJ cord-010119-t1x9gknd 10797 12 educational educational JJ cord-010119-t1x9gknd 10797 13 tool tool NN cord-010119-t1x9gknd 10797 14 to to TO cord-010119-t1x9gknd 10797 15 illustrate illustrate VB cord-010119-t1x9gknd 10797 16 complex complex JJ cord-010119-t1x9gknd 10797 17 and and CC cord-010119-t1x9gknd 10797 18 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 10797 19 topics topic NNS cord-010119-t1x9gknd 10797 20 in in IN cord-010119-t1x9gknd 10797 21 medicine medicine NN cord-010119-t1x9gknd 10797 22 . . . cord-010119-t1x9gknd 10798 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10798 2 goal goal NN cord-010119-t1x9gknd 10798 3 is be VBZ cord-010119-t1x9gknd 10798 4 to to TO cord-010119-t1x9gknd 10798 5 use use VB cord-010119-t1x9gknd 10798 6 and and CC cord-010119-t1x9gknd 10798 7 evaluate evaluate VB cord-010119-t1x9gknd 10798 8 the the DT cord-010119-t1x9gknd 10798 9 relevance relevance NN cord-010119-t1x9gknd 10798 10 of of IN cord-010119-t1x9gknd 10798 11 this this DT cord-010119-t1x9gknd 10798 12 approach approach NN cord-010119-t1x9gknd 10798 13 in in IN cord-010119-t1x9gknd 10798 14 resident resident JJ cord-010119-t1x9gknd 10798 15 education education NN cord-010119-t1x9gknd 10798 16 . . . cord-010119-t1x9gknd 10799 1 Study Study NNP cord-010119-t1x9gknd 10799 2 Design Design NNP cord-010119-t1x9gknd 10799 3 / / SYM cord-010119-t1x9gknd 10799 4 Method method NN cord-010119-t1x9gknd 10799 5 : : : cord-010119-t1x9gknd 10800 1 A a DT cord-010119-t1x9gknd 10800 2 clinical clinical JJ cord-010119-t1x9gknd 10800 3 vignette vignette NN cord-010119-t1x9gknd 10800 4 based base VBN cord-010119-t1x9gknd 10800 5 on on IN cord-010119-t1x9gknd 10800 6 a a DT cord-010119-t1x9gknd 10800 7 placenta placenta NN cord-010119-t1x9gknd 10800 8 accreta accreta NN cord-010119-t1x9gknd 10800 9 case case NN cord-010119-t1x9gknd 10800 10 was be VBD cord-010119-t1x9gknd 10800 11 written write VBN cord-010119-t1x9gknd 10800 12 by by IN cord-010119-t1x9gknd 10800 13 a a DT cord-010119-t1x9gknd 10800 14 pathology pathology NN cord-010119-t1x9gknd 10800 15 resident resident NN cord-010119-t1x9gknd 10800 16 during during IN cord-010119-t1x9gknd 10800 17 the the DT cord-010119-t1x9gknd 10800 18 transfusion transfusion NN cord-010119-t1x9gknd 10800 19 medicine medicine NN cord-010119-t1x9gknd 10800 20 rotation rotation NN cord-010119-t1x9gknd 10800 21 . . . cord-010119-t1x9gknd 10801 1 During during IN cord-010119-t1x9gknd 10801 2 a a DT cord-010119-t1x9gknd 10801 3 two two CD cord-010119-t1x9gknd 10801 4 - - HYPH cord-010119-t1x9gknd 10801 5 week week NN cord-010119-t1x9gknd 10801 6 laboratory laboratory NN cord-010119-t1x9gknd 10801 7 management management NN cord-010119-t1x9gknd 10801 8 course course NN cord-010119-t1x9gknd 10801 9 , , , cord-010119-t1x9gknd 10801 10 residents resident NNS cord-010119-t1x9gknd 10801 11 prepared prepare VBN cord-010119-t1x9gknd 10801 12 for for IN cord-010119-t1x9gknd 10801 13 the the DT cord-010119-t1x9gknd 10801 14 dramatic dramatic JJ cord-010119-t1x9gknd 10801 15 vignette vignette NN cord-010119-t1x9gknd 10801 16 performance performance NN cord-010119-t1x9gknd 10801 17 with with IN cord-010119-t1x9gknd 10801 18 a a DT cord-010119-t1x9gknd 10801 19 focus focus NN cord-010119-t1x9gknd 10801 20 on on IN cord-010119-t1x9gknd 10801 21 transfusion transfusion NN cord-010119-t1x9gknd 10801 22 medicine medicine NN cord-010119-t1x9gknd 10801 23 and and CC cord-010119-t1x9gknd 10801 24 laboratory laboratory NN cord-010119-t1x9gknd 10801 25 management management NN cord-010119-t1x9gknd 10801 26 topics topic NNS cord-010119-t1x9gknd 10801 27 . . . cord-010119-t1x9gknd 10802 1 Each each DT cord-010119-t1x9gknd 10802 2 resident resident NN cord-010119-t1x9gknd 10802 3 completed complete VBD cord-010119-t1x9gknd 10802 4 a a DT cord-010119-t1x9gknd 10802 5 10 10 CD cord-010119-t1x9gknd 10802 6 question question NN cord-010119-t1x9gknd 10802 7 preand preand JJ cord-010119-t1x9gknd 10802 8 post post JJ cord-010119-t1x9gknd 10802 9 - - JJ cord-010119-t1x9gknd 10802 10 test test NN cord-010119-t1x9gknd 10802 11 on on IN cord-010119-t1x9gknd 10802 12 topics topic NNS cord-010119-t1x9gknd 10802 13 related relate VBN cord-010119-t1x9gknd 10802 14 to to IN cord-010119-t1x9gknd 10802 15 the the DT cord-010119-t1x9gknd 10802 16 vignette vignette NN cord-010119-t1x9gknd 10802 17 . . . cord-010119-t1x9gknd 10803 1 Several several JJ cord-010119-t1x9gknd 10803 2 meetings meeting NNS cord-010119-t1x9gknd 10803 3 for for IN cord-010119-t1x9gknd 10803 4 review review NN cord-010119-t1x9gknd 10803 5 and and CC cord-010119-t1x9gknd 10803 6 adaptation adaptation NN cord-010119-t1x9gknd 10803 7 of of IN cord-010119-t1x9gknd 10803 8 the the DT cord-010119-t1x9gknd 10803 9 script script NN cord-010119-t1x9gknd 10803 10 , , , cord-010119-t1x9gknd 10803 11 topic topic NN cord-010119-t1x9gknd 10803 12 discussion discussion NN cord-010119-t1x9gknd 10803 13 , , , cord-010119-t1x9gknd 10803 14 and and CC cord-010119-t1x9gknd 10803 15 rehearsals rehearsal NNS cord-010119-t1x9gknd 10803 16 were be VBD cord-010119-t1x9gknd 10803 17 held hold VBN cord-010119-t1x9gknd 10803 18 . . . cord-010119-t1x9gknd 10804 1 There there EX cord-010119-t1x9gknd 10804 2 were be VBD cord-010119-t1x9gknd 10804 3 several several JJ cord-010119-t1x9gknd 10804 4 commonly commonly RB cord-010119-t1x9gknd 10804 5 encountered encounter VBN cord-010119-t1x9gknd 10804 6 problems problem NNS cord-010119-t1x9gknd 10804 7 and and CC cord-010119-t1x9gknd 10804 8 deviations deviation NNS cord-010119-t1x9gknd 10804 9 from from IN cord-010119-t1x9gknd 10804 10 the the DT cord-010119-t1x9gknd 10804 11 standard standard JJ cord-010119-t1x9gknd 10804 12 operating operating NN cord-010119-t1x9gknd 10804 13 procedures procedure NNS cord-010119-t1x9gknd 10804 14 that that WDT cord-010119-t1x9gknd 10804 15 the the DT cord-010119-t1x9gknd 10804 16 residents resident NNS cord-010119-t1x9gknd 10804 17 in in IN cord-010119-t1x9gknd 10804 18 the the DT cord-010119-t1x9gknd 10804 19 audience audience NN cord-010119-t1x9gknd 10804 20 were be VBD cord-010119-t1x9gknd 10804 21 asked ask VBN cord-010119-t1x9gknd 10804 22 to to TO cord-010119-t1x9gknd 10804 23 identify identify VB cord-010119-t1x9gknd 10804 24 prior prior RB cord-010119-t1x9gknd 10804 25 to to IN cord-010119-t1x9gknd 10804 26 the the DT cord-010119-t1x9gknd 10804 27 performance performance NN cord-010119-t1x9gknd 10804 28 . . . cord-010119-t1x9gknd 10805 1 During during IN cord-010119-t1x9gknd 10805 2 the the DT cord-010119-t1x9gknd 10805 3 skit skit NN cord-010119-t1x9gknd 10805 4 , , , cord-010119-t1x9gknd 10805 5 each each DT cord-010119-t1x9gknd 10805 6 resident resident NN cord-010119-t1x9gknd 10805 7 presented present VBD cord-010119-t1x9gknd 10805 8 at at IN cord-010119-t1x9gknd 10805 9 least least RBS cord-010119-t1x9gknd 10805 10 one one CD cord-010119-t1x9gknd 10805 11 major major JJ cord-010119-t1x9gknd 10805 12 transfusion transfusion NN cord-010119-t1x9gknd 10805 13 management management NN cord-010119-t1x9gknd 10805 14 teaching teaching NN cord-010119-t1x9gknd 10805 15 point point NN cord-010119-t1x9gknd 10805 16 . . . cord-010119-t1x9gknd 10806 1 Results/ Results/ . cord-010119-t1x9gknd 10807 1 Finding finding NN cord-010119-t1x9gknd 10807 2 : : : cord-010119-t1x9gknd 10808 1 The the DT cord-010119-t1x9gknd 10808 2 educational educational JJ cord-010119-t1x9gknd 10808 3 activity activity NN cord-010119-t1x9gknd 10808 4 , , , cord-010119-t1x9gknd 10808 5 including include VBG cord-010119-t1x9gknd 10808 6 the the DT cord-010119-t1x9gknd 10808 7 40 40 CD cord-010119-t1x9gknd 10808 8 minute minute NN cord-010119-t1x9gknd 10808 9 vignette vignette NN cord-010119-t1x9gknd 10808 10 performance performance NN cord-010119-t1x9gknd 10808 11 and and CC cord-010119-t1x9gknd 10808 12 the the DT cord-010119-t1x9gknd 10808 13 20 20 CD cord-010119-t1x9gknd 10808 14 minute minute NN cord-010119-t1x9gknd 10808 15 discussion discussion NN cord-010119-t1x9gknd 10808 16 , , , cord-010119-t1x9gknd 10808 17 was be VBD cord-010119-t1x9gknd 10808 18 completed complete VBN cord-010119-t1x9gknd 10808 19 with with IN cord-010119-t1x9gknd 10808 20 a a DT cord-010119-t1x9gknd 10808 21 focus focus NN cord-010119-t1x9gknd 10808 22 on on IN cord-010119-t1x9gknd 10808 23 : : : cord-010119-t1x9gknd 10808 24 communication communication NN cord-010119-t1x9gknd 10808 25 between between IN cord-010119-t1x9gknd 10808 26 the the DT cord-010119-t1x9gknd 10808 27 operating operating NN cord-010119-t1x9gknd 10808 28 room room NN cord-010119-t1x9gknd 10808 29 and and CC cord-010119-t1x9gknd 10808 30 the the DT cord-010119-t1x9gknd 10808 31 blood blood NN cord-010119-t1x9gknd 10808 32 bank bank NN cord-010119-t1x9gknd 10808 33 during during IN cord-010119-t1x9gknd 10808 34 surgery surgery NN cord-010119-t1x9gknd 10808 35 , , , cord-010119-t1x9gknd 10808 36 maximum maximum JJ cord-010119-t1x9gknd 10808 37 surgical surgical JJ cord-010119-t1x9gknd 10808 38 blood blood NN cord-010119-t1x9gknd 10808 39 order order NN cord-010119-t1x9gknd 10808 40 schedule schedule NN cord-010119-t1x9gknd 10808 41 , , , cord-010119-t1x9gknd 10808 42 pre pre JJ cord-010119-t1x9gknd 10808 43 - - JJ cord-010119-t1x9gknd 10808 44 transfusion transfusion JJ cord-010119-t1x9gknd 10808 45 testing testing NN cord-010119-t1x9gknd 10808 46 , , , cord-010119-t1x9gknd 10808 47 transfusion transfusion NN cord-010119-t1x9gknd 10808 48 safety safety NN cord-010119-t1x9gknd 10808 49 , , , cord-010119-t1x9gknd 10808 50 informed informed JJ cord-010119-t1x9gknd 10808 51 consent consent NN cord-010119-t1x9gknd 10808 52 , , , cord-010119-t1x9gknd 10808 53 massive massive JJ cord-010119-t1x9gknd 10808 54 transfusion transfusion NN cord-010119-t1x9gknd 10808 55 protocol protocol NN cord-010119-t1x9gknd 10808 56 , , , cord-010119-t1x9gknd 10808 57 emergency emergency NN cord-010119-t1x9gknd 10808 58 release release NN cord-010119-t1x9gknd 10808 59 blood blood NN cord-010119-t1x9gknd 10808 60 products product NNS cord-010119-t1x9gknd 10808 61 , , , cord-010119-t1x9gknd 10808 62 thromboelastometry thromboelastometry NNP cord-010119-t1x9gknd 10808 63 interpretation interpretation NN cord-010119-t1x9gknd 10808 64 , , , cord-010119-t1x9gknd 10808 65 patient patient JJ cord-010119-t1x9gknd 10808 66 safety safety NN cord-010119-t1x9gknd 10808 67 , , , cord-010119-t1x9gknd 10808 68 adverse adverse JJ cord-010119-t1x9gknd 10808 69 events event NNS cord-010119-t1x9gknd 10808 70 , , , cord-010119-t1x9gknd 10808 71 and and CC cord-010119-t1x9gknd 10808 72 root root NN cord-010119-t1x9gknd 10808 73 cause cause NN cord-010119-t1x9gknd 10808 74 analysis analysis NN cord-010119-t1x9gknd 10808 75 . . . cord-010119-t1x9gknd 10809 1 All all DT cord-010119-t1x9gknd 10809 2 performers performer NNS cord-010119-t1x9gknd 10809 3 significantly significantly RB cord-010119-t1x9gknd 10809 4 improved improve VBD cord-010119-t1x9gknd 10809 5 their -PRON- PRP$ cord-010119-t1x9gknd 10809 6 scores score NNS cord-010119-t1x9gknd 10809 7 in in IN cord-010119-t1x9gknd 10809 8 the the DT cord-010119-t1x9gknd 10809 9 post post JJ cord-010119-t1x9gknd 10809 10 - - JJ cord-010119-t1x9gknd 10809 11 test test JJ cord-010119-t1x9gknd 10809 12 ( ( -LRB- cord-010119-t1x9gknd 10809 13 mean mean VB cord-010119-t1x9gknd 10809 14 95 95 CD cord-010119-t1x9gknd 10809 15 1 1 CD cord-010119-t1x9gknd 10809 16 4 4 CD cord-010119-t1x9gknd 10809 17 % % NN cord-010119-t1x9gknd 10809 18 ) ) -RRB- cord-010119-t1x9gknd 10809 19 when when WRB cord-010119-t1x9gknd 10809 20 compared compare VBN cord-010119-t1x9gknd 10809 21 to to IN cord-010119-t1x9gknd 10809 22 the the DT cord-010119-t1x9gknd 10809 23 pre pre JJ cord-010119-t1x9gknd 10809 24 - - JJ cord-010119-t1x9gknd 10809 25 test test JJ cord-010119-t1x9gknd 10809 26 scores score NNS cord-010119-t1x9gknd 10809 27 ( ( -LRB- cord-010119-t1x9gknd 10809 28 mean mean VBP cord-010119-t1x9gknd 10809 29 67 67 CD cord-010119-t1x9gknd 10809 30 1 1 CD cord-010119-t1x9gknd 10809 31 26 26 CD cord-010119-t1x9gknd 10809 32 % % NN cord-010119-t1x9gknd 10809 33 ) ) -RRB- cord-010119-t1x9gknd 10809 34 ttest ttest NNP cord-010119-t1x9gknd 10809 35 p<0.017 p<0.017 CD cord-010119-t1x9gknd 10809 36 . . . cord-010119-t1x9gknd 10810 1 During during IN cord-010119-t1x9gknd 10810 2 the the DT cord-010119-t1x9gknd 10810 3 vignette vignette NN cord-010119-t1x9gknd 10810 4 discussion discussion NN cord-010119-t1x9gknd 10810 5 , , , cord-010119-t1x9gknd 10810 6 residents resident NNS cord-010119-t1x9gknd 10810 7 together together RB cord-010119-t1x9gknd 10810 8 identified identify VBD cord-010119-t1x9gknd 10810 9 all all PDT cord-010119-t1x9gknd 10810 10 the the DT cord-010119-t1x9gknd 10810 11 intended intend VBN cord-010119-t1x9gknd 10810 12 non non NN cord-010119-t1x9gknd 10810 13 - - NNS cord-010119-t1x9gknd 10810 14 conformances conformance NNS cord-010119-t1x9gknd 10810 15 and and CC cord-010119-t1x9gknd 10810 16 answered answer VBN cord-010119-t1x9gknd 10810 17 related related JJ cord-010119-t1x9gknd 10810 18 questions question NNS cord-010119-t1x9gknd 10810 19 . . . cord-010119-t1x9gknd 10811 1 Residents resident NNS cord-010119-t1x9gknd 10811 2 in in IN cord-010119-t1x9gknd 10811 3 the the DT cord-010119-t1x9gknd 10811 4 audience audience NN cord-010119-t1x9gknd 10811 5 actively actively RB cord-010119-t1x9gknd 10811 6 participated participate VBD cord-010119-t1x9gknd 10811 7 in in IN cord-010119-t1x9gknd 10811 8 the the DT cord-010119-t1x9gknd 10811 9 post post JJ cord-010119-t1x9gknd 10811 10 skit skit NN cord-010119-t1x9gknd 10811 11 discussion discussion NN cord-010119-t1x9gknd 10811 12 and and CC cord-010119-t1x9gknd 10811 13 90 90 CD cord-010119-t1x9gknd 10811 14 % % NN cord-010119-t1x9gknd 10811 15 reported report VBD cord-010119-t1x9gknd 10811 16 a a DT cord-010119-t1x9gknd 10811 17 satisfactory satisfactory JJ cord-010119-t1x9gknd 10811 18 learning learning NN cord-010119-t1x9gknd 10811 19 experience experience NN cord-010119-t1x9gknd 10811 20 . . . cord-010119-t1x9gknd 10812 1 Conclusion conclusion NN cord-010119-t1x9gknd 10812 2 : : : cord-010119-t1x9gknd 10813 1 Dramatic dramatic JJ cord-010119-t1x9gknd 10813 2 clinical clinical JJ cord-010119-t1x9gknd 10813 3 vignettes vignette NNS cord-010119-t1x9gknd 10813 4 can can MD cord-010119-t1x9gknd 10813 5 illustrate illustrate VB cord-010119-t1x9gknd 10813 6 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 10813 7 complex complex JJ cord-010119-t1x9gknd 10813 8 interactions interaction NNS cord-010119-t1x9gknd 10813 9 that that WDT cord-010119-t1x9gknd 10813 10 are be VBP cord-010119-t1x9gknd 10813 11 of of IN cord-010119-t1x9gknd 10813 12 pivotal pivotal JJ cord-010119-t1x9gknd 10813 13 importance importance NN cord-010119-t1x9gknd 10813 14 in in IN cord-010119-t1x9gknd 10813 15 the the DT cord-010119-t1x9gknd 10813 16 daily daily JJ cord-010119-t1x9gknd 10813 17 activities activity NNS cord-010119-t1x9gknd 10813 18 and and CC cord-010119-t1x9gknd 10813 19 professional professional JJ cord-010119-t1x9gknd 10813 20 development development NN cord-010119-t1x9gknd 10813 21 of of IN cord-010119-t1x9gknd 10813 22 pathology pathology NN cord-010119-t1x9gknd 10813 23 residents resident NNS cord-010119-t1x9gknd 10813 24 . . . cord-010119-t1x9gknd 10814 1 With with IN cord-010119-t1x9gknd 10814 2 specific specific JJ cord-010119-t1x9gknd 10814 3 structured structured JJ cord-010119-t1x9gknd 10814 4 goals goal NNS cord-010119-t1x9gknd 10814 5 , , , cord-010119-t1x9gknd 10814 6 clinical clinical JJ cord-010119-t1x9gknd 10814 7 dramatic dramatic JJ cord-010119-t1x9gknd 10814 8 vignettes vignette NNS cord-010119-t1x9gknd 10814 9 can can MD cord-010119-t1x9gknd 10814 10 be be VB cord-010119-t1x9gknd 10814 11 used use VBN cord-010119-t1x9gknd 10814 12 as as IN cord-010119-t1x9gknd 10814 13 a a DT cord-010119-t1x9gknd 10814 14 complementary complementary JJ cord-010119-t1x9gknd 10814 15 educational educational JJ cord-010119-t1x9gknd 10814 16 tool tool NN cord-010119-t1x9gknd 10814 17 to to TO cord-010119-t1x9gknd 10814 18 illustrate illustrate VB cord-010119-t1x9gknd 10814 19 challenging challenging JJ cord-010119-t1x9gknd 10814 20 topics topic NNS cord-010119-t1x9gknd 10814 21 in in IN cord-010119-t1x9gknd 10814 22 an an DT cord-010119-t1x9gknd 10814 23 integrative integrative JJ cord-010119-t1x9gknd 10814 24 way way NN cord-010119-t1x9gknd 10814 25 that that WDT cord-010119-t1x9gknd 10814 26 is be VBZ cord-010119-t1x9gknd 10814 27 enjoyable enjoyable JJ cord-010119-t1x9gknd 10814 28 and and CC cord-010119-t1x9gknd 10814 29 easy easy JJ cord-010119-t1x9gknd 10814 30 to to TO cord-010119-t1x9gknd 10814 31 understand understand VB cord-010119-t1x9gknd 10814 32 and and CC cord-010119-t1x9gknd 10814 33 remember remember VB cord-010119-t1x9gknd 10814 34 . . . cord-010119-t1x9gknd 10815 1 The the DT cord-010119-t1x9gknd 10815 2 skit skit NN cord-010119-t1x9gknd 10815 3 performers performer NNS cord-010119-t1x9gknd 10815 4 benefit benefit VBP cord-010119-t1x9gknd 10815 5 from from IN cord-010119-t1x9gknd 10815 6 the the DT cord-010119-t1x9gknd 10815 7 activity activity NN cord-010119-t1x9gknd 10815 8 further further RB cord-010119-t1x9gknd 10815 9 by by IN cord-010119-t1x9gknd 10815 10 preparing prepare VBG cord-010119-t1x9gknd 10815 11 and and CC cord-010119-t1x9gknd 10815 12 extensively extensively RB cord-010119-t1x9gknd 10815 13 studying study VBG cord-010119-t1x9gknd 10815 14 the the DT cord-010119-t1x9gknd 10815 15 topics topic NNS cord-010119-t1x9gknd 10815 16 to to TO cord-010119-t1x9gknd 10815 17 deliver deliver VB cord-010119-t1x9gknd 10815 18 a a DT cord-010119-t1x9gknd 10815 19 multifaceted multifaceted JJ cord-010119-t1x9gknd 10815 20 and and CC cord-010119-t1x9gknd 10815 21 coherent coherent JJ cord-010119-t1x9gknd 10815 22 presentation presentation NN cord-010119-t1x9gknd 10815 23 with with IN cord-010119-t1x9gknd 10815 24 emphasis emphasis NN cord-010119-t1x9gknd 10815 25 on on IN cord-010119-t1x9gknd 10815 26 the the DT cord-010119-t1x9gknd 10815 27 integral integral JJ cord-010119-t1x9gknd 10815 28 role role NN cord-010119-t1x9gknd 10815 29 of of IN cord-010119-t1x9gknd 10815 30 the the DT cord-010119-t1x9gknd 10815 31 laboratory laboratory NN cord-010119-t1x9gknd 10815 32 and and CC cord-010119-t1x9gknd 10815 33 transfusion transfusion NN cord-010119-t1x9gknd 10815 34 medicine medicine NN cord-010119-t1x9gknd 10815 35 in in IN cord-010119-t1x9gknd 10815 36 patient patient JJ cord-010119-t1x9gknd 10815 37 care care NN cord-010119-t1x9gknd 10815 38 . . . cord-010119-t1x9gknd 10816 1 Hannele Hannele NNP cord-010119-t1x9gknd 10816 2 Sareneva Sareneva NNP cord-010119-t1x9gknd 10816 3 * * NFP cord-010119-t1x9gknd 10816 4 , , , cord-010119-t1x9gknd 10816 5 Susanna Susanna NNP cord-010119-t1x9gknd 10816 6 Sainio Sainio NNP cord-010119-t1x9gknd 10816 7 , , , cord-010119-t1x9gknd 10816 8 Inna Inna NNP cord-010119-t1x9gknd 10816 9 Sareneva Sareneva NNP cord-010119-t1x9gknd 10816 10 , , , cord-010119-t1x9gknd 10816 11 Tiia Tiia NNP cord-010119-t1x9gknd 10816 12 Kivipuro Kivipuro NNP cord-010119-t1x9gknd 10816 13 and and CC cord-010119-t1x9gknd 10816 14 Taru Taru NNP cord-010119-t1x9gknd 10816 15 Jaske Jaske NNP cord-010119-t1x9gknd 10816 16 . . . cord-010119-t1x9gknd 10817 1 Finnish Finnish NNP cord-010119-t1x9gknd 10817 2 Red Red NNP cord-010119-t1x9gknd 10817 3 Cross Cross NNP cord-010119-t1x9gknd 10817 4 Blood Blood NNP cord-010119-t1x9gknd 10817 5 Service Service NNP cord-010119-t1x9gknd 10817 6 Background Background NNP cord-010119-t1x9gknd 10817 7 / / SYM cord-010119-t1x9gknd 10817 8 Case Case NNP cord-010119-t1x9gknd 10817 9 Studies Studies NNPS cord-010119-t1x9gknd 10817 10 : : : cord-010119-t1x9gknd 10817 11 The the DT cord-010119-t1x9gknd 10817 12 Finnish finnish JJ cord-010119-t1x9gknd 10817 13 Red Red NNP cord-010119-t1x9gknd 10817 14 Cross Cross NNP cord-010119-t1x9gknd 10817 15 Blood Blood NNP cord-010119-t1x9gknd 10817 16 Service Service NNP cord-010119-t1x9gknd 10817 17 ( ( -LRB- cord-010119-t1x9gknd 10817 18 FRCBS FRCBS NNP cord-010119-t1x9gknd 10817 19 ) ) -RRB- cord-010119-t1x9gknd 10817 20 is be VBZ cord-010119-t1x9gknd 10817 21 the the DT cord-010119-t1x9gknd 10817 22 nationwide nationwide JJ cord-010119-t1x9gknd 10817 23 blood blood NN cord-010119-t1x9gknd 10817 24 service service NN cord-010119-t1x9gknd 10817 25 provider provider NN cord-010119-t1x9gknd 10817 26 in in IN cord-010119-t1x9gknd 10817 27 Finland Finland NNP cord-010119-t1x9gknd 10817 28 , , , cord-010119-t1x9gknd 10817 29 responsible responsible JJ cord-010119-t1x9gknd 10817 30 for for IN cord-010119-t1x9gknd 10817 31 collection collection NN cord-010119-t1x9gknd 10817 32 , , , cord-010119-t1x9gknd 10817 33 testing testing NN cord-010119-t1x9gknd 10817 34 , , , cord-010119-t1x9gknd 10817 35 processing processing NN cord-010119-t1x9gknd 10817 36 and and CC cord-010119-t1x9gknd 10817 37 distribution distribution NN cord-010119-t1x9gknd 10817 38 of of IN cord-010119-t1x9gknd 10817 39 blood blood NN cord-010119-t1x9gknd 10817 40 products product NNS cord-010119-t1x9gknd 10817 41 to to IN cord-010119-t1x9gknd 10817 42 all all DT cord-010119-t1x9gknd 10817 43 hospitals hospital NNS cord-010119-t1x9gknd 10817 44 and and CC cord-010119-t1x9gknd 10817 45 health health NN cord-010119-t1x9gknd 10817 46 care care NN cord-010119-t1x9gknd 10817 47 providers provider NNS cord-010119-t1x9gknd 10817 48 . . . cord-010119-t1x9gknd 10818 1 The the DT cord-010119-t1x9gknd 10818 2 FRCBS FRCBS NNP cord-010119-t1x9gknd 10818 3 serves serve VBZ cord-010119-t1x9gknd 10818 4 as as IN cord-010119-t1x9gknd 10818 5 the the DT cord-010119-t1x9gknd 10818 6 National National NNP cord-010119-t1x9gknd 10818 7 Blood Blood NNP cord-010119-t1x9gknd 10818 8 Group Group NNP cord-010119-t1x9gknd 10818 9 Reference Reference NNP cord-010119-t1x9gknd 10818 10 Laboratory Laboratory NNP cord-010119-t1x9gknd 10818 11 and and CC cord-010119-t1x9gknd 10818 12 provides provide VBZ cord-010119-t1x9gknd 10818 13 a a DT cord-010119-t1x9gknd 10818 14 wide wide JJ cord-010119-t1x9gknd 10818 15 range range NN cord-010119-t1x9gknd 10818 16 of of IN cord-010119-t1x9gknd 10818 17 other other JJ cord-010119-t1x9gknd 10818 18 laboratory laboratory NN cord-010119-t1x9gknd 10818 19 services service NNS cord-010119-t1x9gknd 10819 1 e.g. e.g. IN cord-010119-t1x9gknd 10819 2 tests test NNS cord-010119-t1x9gknd 10819 3 for for IN cord-010119-t1x9gknd 10819 4 hemostasis hemostasis NN cord-010119-t1x9gknd 10819 5 and and CC cord-010119-t1x9gknd 10819 6 tissue tissue NN cord-010119-t1x9gknd 10819 7 typing typing NN cord-010119-t1x9gknd 10819 8 for for IN cord-010119-t1x9gknd 10819 9 possible possible JJ cord-010119-t1x9gknd 10819 10 donors donor NNS cord-010119-t1x9gknd 10819 11 as as RB cord-010119-t1x9gknd 10819 12 well well RB cord-010119-t1x9gknd 10819 13 as as IN cord-010119-t1x9gknd 10819 14 patients patient NNS cord-010119-t1x9gknd 10819 15 waiting wait VBG cord-010119-t1x9gknd 10819 16 for for IN cord-010119-t1x9gknd 10819 17 organ organ NN cord-010119-t1x9gknd 10819 18 or or CC cord-010119-t1x9gknd 10819 19 stem stem NN cord-010119-t1x9gknd 10819 20 cell cell NN cord-010119-t1x9gknd 10819 21 transplantation transplantation NN cord-010119-t1x9gknd 10819 22 . . . cord-010119-t1x9gknd 10820 1 FRCBS FRCBS NNP cord-010119-t1x9gknd 10820 2 also also RB cord-010119-t1x9gknd 10820 3 performs perform VBZ cord-010119-t1x9gknd 10820 4 antenatal antenatal JJ cord-010119-t1x9gknd 10820 5 blood blood NN cord-010119-t1x9gknd 10820 6 group group NN cord-010119-t1x9gknd 10820 7 and and CC cord-010119-t1x9gknd 10820 8 RBC RBC NNP cord-010119-t1x9gknd 10820 9 antibody antibody NN cord-010119-t1x9gknd 10820 10 tests test VBZ cord-010119-t1x9gknd 10820 11 covering cover VBG cord-010119-t1x9gknd 10820 12 whole whole JJ cord-010119-t1x9gknd 10820 13 country country NN cord-010119-t1x9gknd 10820 14 . . . cord-010119-t1x9gknd 10821 1 As as IN cord-010119-t1x9gknd 10821 2 a a DT cord-010119-t1x9gknd 10821 3 sole sole JJ cord-010119-t1x9gknd 10821 4 national national JJ cord-010119-t1x9gknd 10821 5 operator operator NN cord-010119-t1x9gknd 10821 6 we -PRON- PRP cord-010119-t1x9gknd 10821 7 are be VBP cord-010119-t1x9gknd 10821 8 providing provide VBG cord-010119-t1x9gknd 10821 9 educational educational JJ cord-010119-t1x9gknd 10821 10 services service NNS cord-010119-t1x9gknd 10821 11 to to TO cord-010119-t1x9gknd 10821 12 ensure ensure VB cord-010119-t1x9gknd 10821 13 the the DT cord-010119-t1x9gknd 10821 14 safe safe JJ cord-010119-t1x9gknd 10821 15 use use NN cord-010119-t1x9gknd 10821 16 of of IN cord-010119-t1x9gknd 10821 17 blood blood NN cord-010119-t1x9gknd 10821 18 products product NNS cord-010119-t1x9gknd 10821 19 as as RB cord-010119-t1x9gknd 10821 20 well well RB cord-010119-t1x9gknd 10821 21 as as IN cord-010119-t1x9gknd 10821 22 accurate accurate JJ cord-010119-t1x9gknd 10821 23 use use NN cord-010119-t1x9gknd 10821 24 of of IN cord-010119-t1x9gknd 10821 25 our -PRON- PRP$ cord-010119-t1x9gknd 10821 26 laboratory laboratory NN cord-010119-t1x9gknd 10821 27 services service NNS cord-010119-t1x9gknd 10821 28 . . . cord-010119-t1x9gknd 10822 1 Study Study NNP cord-010119-t1x9gknd 10822 2 Design Design NNP cord-010119-t1x9gknd 10822 3 / / SYM cord-010119-t1x9gknd 10822 4 Methods method NNS cord-010119-t1x9gknd 10822 5 : : : cord-010119-t1x9gknd 10822 6 We -PRON- PRP cord-010119-t1x9gknd 10822 7 have have VBP cord-010119-t1x9gknd 10822 8 performed perform VBN cord-010119-t1x9gknd 10822 9 customer customer NN cord-010119-t1x9gknd 10822 10 surveys survey NNS cord-010119-t1x9gknd 10822 11 to to IN cord-010119-t1x9gknd 10822 12 healthcare healthcare NN cord-010119-t1x9gknd 10822 13 professionals professional NNS cord-010119-t1x9gknd 10822 14 to to TO cord-010119-t1x9gknd 10822 15 assemble assemble VB cord-010119-t1x9gknd 10822 16 the the DT cord-010119-t1x9gknd 10822 17 needs need NNS cord-010119-t1x9gknd 10822 18 for for IN cord-010119-t1x9gknd 10822 19 education education NN cord-010119-t1x9gknd 10822 20 . . . cord-010119-t1x9gknd 10823 1 Based base VBN cord-010119-t1x9gknd 10823 2 on on IN cord-010119-t1x9gknd 10823 3 these these DT cord-010119-t1x9gknd 10823 4 results result NNS cord-010119-t1x9gknd 10823 5 and and CC cord-010119-t1x9gknd 10823 6 continuous continuous JJ cord-010119-t1x9gknd 10823 7 feedback feedback NN cord-010119-t1x9gknd 10823 8 FRCBS FRCBS NNP cord-010119-t1x9gknd 10823 9 provides provide VBZ cord-010119-t1x9gknd 10823 10 hospital hospital NN cord-010119-t1x9gknd 10823 11 customers customer NNS cord-010119-t1x9gknd 10823 12 in in IN cord-010119-t1x9gknd 10823 13 blood blood NN cord-010119-t1x9gknd 10823 14 banks bank NNS cord-010119-t1x9gknd 10823 15 and and CC cord-010119-t1x9gknd 10823 16 clinics clinic NNS cord-010119-t1x9gknd 10823 17 the the DT cord-010119-t1x9gknd 10823 18 following follow VBG cord-010119-t1x9gknd 10823 19 additional additional JJ cord-010119-t1x9gknd 10823 20 services service NNS cord-010119-t1x9gknd 10823 21 : : : cord-010119-t1x9gknd 10823 22 * * NFP cord-010119-t1x9gknd 10823 23 regular regular JJ cord-010119-t1x9gknd 10823 24 education education NN cord-010119-t1x9gknd 10824 1 * * NFP cord-010119-t1x9gknd 10824 2 e e LS cord-010119-t1x9gknd 10824 3 - - HYPH cord-010119-t1x9gknd 10824 4 learning learning JJ cord-010119-t1x9gknd 10824 5 application application NN cord-010119-t1x9gknd 10824 6 of of IN cord-010119-t1x9gknd 10824 7 transfusion transfusion NN cord-010119-t1x9gknd 10824 8 medicine medicine NN cord-010119-t1x9gknd 10825 1 * * NFP cord-010119-t1x9gknd 10825 2 Handbook Handbook NNP cord-010119-t1x9gknd 10825 3 for for IN cord-010119-t1x9gknd 10825 4 Blood blood NN cord-010119-t1x9gknd 10825 5 Products product NNS cord-010119-t1x9gknd 10825 6 on on IN cord-010119-t1x9gknd 10825 7 the the DT cord-010119-t1x9gknd 10825 8 web web NN cord-010119-t1x9gknd 10825 9 site site NN cord-010119-t1x9gknd 10825 10 * * NFP cord-010119-t1x9gknd 10825 11 reports report VBZ cord-010119-t1x9gknd 10825 12 to to IN cord-010119-t1x9gknd 10825 13 hospitals hospital NNS cord-010119-t1x9gknd 10825 14 for for IN cord-010119-t1x9gknd 10825 15 their -PRON- PRP$ cord-010119-t1x9gknd 10825 16 use use NN cord-010119-t1x9gknd 10825 17 of of IN cord-010119-t1x9gknd 10825 18 blood blood NN cord-010119-t1x9gknd 10825 19 products product NNS cord-010119-t1x9gknd 10825 20 * * NFP cord-010119-t1x9gknd 10825 21 annual annual JJ cord-010119-t1x9gknd 10825 22 national national JJ cord-010119-t1x9gknd 10825 23 blood blood NN cord-010119-t1x9gknd 10825 24 safety safety NN cord-010119-t1x9gknd 10825 25 reports report VBZ cord-010119-t1x9gknd 10825 26 Regular regular JJ cord-010119-t1x9gknd 10825 27 elements element NNS cord-010119-t1x9gknd 10825 28 of of IN cord-010119-t1x9gknd 10825 29 our -PRON- PRP$ cord-010119-t1x9gknd 10825 30 educational educational JJ cord-010119-t1x9gknd 10825 31 program program NN cord-010119-t1x9gknd 10825 32 are be VBP cord-010119-t1x9gknd 10825 33 the the DT cord-010119-t1x9gknd 10825 34 practical practical JJ cord-010119-t1x9gknd 10825 35 , , , cord-010119-t1x9gknd 10825 36 problem problem NN cord-010119-t1x9gknd 10825 37 solving solve VBG cord-010119-t1x9gknd 10825 38 course course NN cord-010119-t1x9gknd 10825 39 for for IN cord-010119-t1x9gknd 10825 40 blood blood NN cord-010119-t1x9gknd 10825 41 bank bank NN cord-010119-t1x9gknd 10825 42 personal personal JJ cord-010119-t1x9gknd 10825 43 and and CC cord-010119-t1x9gknd 10825 44 safe safe JJ cord-010119-t1x9gknd 10825 45 transfusion transfusion NN cord-010119-t1x9gknd 10825 46 training training NN cord-010119-t1x9gknd 10825 47 day day NN cord-010119-t1x9gknd 10825 48 for for IN cord-010119-t1x9gknd 10825 49 clinicians clinician NNS cord-010119-t1x9gknd 10825 50 . . . cord-010119-t1x9gknd 10826 1 For for IN cord-010119-t1x9gknd 10826 2 every every DT cord-010119-t1x9gknd 10826 3 education education NN cord-010119-t1x9gknd 10826 4 we -PRON- PRP cord-010119-t1x9gknd 10826 5 collect collect VBP cord-010119-t1x9gknd 10826 6 numerical numerical JJ cord-010119-t1x9gknd 10826 7 feedback feedback NN cord-010119-t1x9gknd 10826 8 as as IN cord-010119-t1x9gknd 10826 9 following follow VBG cord-010119-t1x9gknd 10826 10 : : : cord-010119-t1x9gknd 10826 11 " " `` cord-010119-t1x9gknd 10826 12 How how WRB cord-010119-t1x9gknd 10826 13 did do VBD cord-010119-t1x9gknd 10826 14 the the DT cord-010119-t1x9gknd 10826 15 education education NN cord-010119-t1x9gknd 10826 16 responded respond VBD cord-010119-t1x9gknd 10826 17 Your -PRON- PRP$ cord-010119-t1x9gknd 10826 18 expectations expectation NNS cord-010119-t1x9gknd 10826 19 " " '' cord-010119-t1x9gknd 10826 20 and and CC cord-010119-t1x9gknd 10826 21 " " `` cord-010119-t1x9gknd 10826 22 Can Can MD cord-010119-t1x9gknd 10826 23 You -PRON- PRP cord-010119-t1x9gknd 10826 24 utilize utilize VB cord-010119-t1x9gknd 10826 25 the the DT cord-010119-t1x9gknd 10826 26 knowledge knowledge NN cord-010119-t1x9gknd 10826 27 in in IN cord-010119-t1x9gknd 10826 28 practice practice NN cord-010119-t1x9gknd 10826 29 " " '' cord-010119-t1x9gknd 10826 30 . . . cord-010119-t1x9gknd 10827 1 We -PRON- PRP cord-010119-t1x9gknd 10827 2 also also RB cord-010119-t1x9gknd 10827 3 inquire inquire VBP cord-010119-t1x9gknd 10827 4 " " `` cord-010119-t1x9gknd 10827 5 How how WRB cord-010119-t1x9gknd 10827 6 likely likely RB cord-010119-t1x9gknd 10827 7 You -PRON- PRP cord-010119-t1x9gknd 10827 8 would would MD cord-010119-t1x9gknd 10827 9 recommend recommend VB cord-010119-t1x9gknd 10827 10 the the DT cord-010119-t1x9gknd 10827 11 training training NN cord-010119-t1x9gknd 10827 12 for for IN cord-010119-t1x9gknd 10827 13 Your -PRON- PRP$ cord-010119-t1x9gknd 10827 14 colleges college NNS cord-010119-t1x9gknd 10827 15 " " '' cord-010119-t1x9gknd 10827 16 indicating indicate VBG cord-010119-t1x9gknd 10827 17 net net JJ cord-010119-t1x9gknd 10827 18 promoter promoter NN cord-010119-t1x9gknd 10827 19 score score NN cord-010119-t1x9gknd 10827 20 ( ( -LRB- cord-010119-t1x9gknd 10827 21 NPS NPS NNP cord-010119-t1x9gknd 10827 22 ) ) -RRB- cord-010119-t1x9gknd 10827 23 . . . cord-010119-t1x9gknd 10828 1 Results/ Results/ . cord-010119-t1x9gknd 10829 1 Findings finding NNS cord-010119-t1x9gknd 10829 2 : : : cord-010119-t1x9gknd 10829 3 More More JJR cord-010119-t1x9gknd 10829 4 than than IN cord-010119-t1x9gknd 10829 5 350 350 CD cord-010119-t1x9gknd 10829 6 healthcare healthcare NN cord-010119-t1x9gknd 10829 7 professionals professional NNS cord-010119-t1x9gknd 10829 8 participate participate VBP cord-010119-t1x9gknd 10829 9 training training NN cord-010119-t1x9gknd 10829 10 days day NNS cord-010119-t1x9gknd 10829 11 at at IN cord-010119-t1x9gknd 10829 12 FRCBS FRCBS NNP cord-010119-t1x9gknd 10829 13 annually annually RB cord-010119-t1x9gknd 10829 14 . . . cord-010119-t1x9gknd 10830 1 In in IN cord-010119-t1x9gknd 10830 2 addition addition NN cord-010119-t1x9gknd 10830 3 our -PRON- PRP$ cord-010119-t1x9gknd 10830 4 experts expert NNS cord-010119-t1x9gknd 10830 5 give give VBP cord-010119-t1x9gknd 10830 6 tens ten NNS cord-010119-t1x9gknd 10830 7 of of IN cord-010119-t1x9gknd 10830 8 lectures lecture NNS cord-010119-t1x9gknd 10830 9 at at IN cord-010119-t1x9gknd 10830 10 hospitals hospital NNS cord-010119-t1x9gknd 10830 11 across across IN cord-010119-t1x9gknd 10830 12 Finland Finland NNP cord-010119-t1x9gknd 10830 13 . . . cord-010119-t1x9gknd 10831 1 Feedback Feedback NNS cord-010119-t1x9gknd 10831 2 from from IN cord-010119-t1x9gknd 10831 3 educations education NNS cord-010119-t1x9gknd 10831 4 has have VBZ cord-010119-t1x9gknd 10831 5 been be VBN cord-010119-t1x9gknd 10831 6 very very RB cord-010119-t1x9gknd 10831 7 good good JJ cord-010119-t1x9gknd 10831 8 , , , cord-010119-t1x9gknd 10831 9 varying vary VBG cord-010119-t1x9gknd 10831 10 between between IN cord-010119-t1x9gknd 10831 11 8.3 8.3 CD cord-010119-t1x9gknd 10831 12 to to IN cord-010119-t1x9gknd 10831 13 9.4 9.4 CD cord-010119-t1x9gknd 10831 14 ( ( -LRB- cord-010119-t1x9gknd 10831 15 in in IN cord-010119-t1x9gknd 10831 16 the the DT cord-010119-t1x9gknd 10831 17 range range NN cord-010119-t1x9gknd 10831 18 of of IN cord-010119-t1x9gknd 10831 19 4 4 CD cord-010119-t1x9gknd 10831 20 - - SYM cord-010119-t1x9gknd 10831 21 10 10 CD cord-010119-t1x9gknd 10831 22 ) ) -RRB- cord-010119-t1x9gknd 10831 23 . . . cord-010119-t1x9gknd 10832 1 NPS NPS NNP cord-010119-t1x9gknd 10832 2 varies vary VBZ cord-010119-t1x9gknd 10832 3 between between IN cord-010119-t1x9gknd 10832 4 83 83 CD cord-010119-t1x9gknd 10832 5 and and CC cord-010119-t1x9gknd 10832 6 98 98 CD cord-010119-t1x9gknd 10832 7 . . . cord-010119-t1x9gknd 10833 1 According accord VBG cord-010119-t1x9gknd 10833 2 to to IN cord-010119-t1x9gknd 10833 3 customer customer NN cord-010119-t1x9gknd 10833 4 surveys survey NNS cord-010119-t1x9gknd 10833 5 FRCBS FRCBS NNP cord-010119-t1x9gknd 10833 6 provides provide VBZ cord-010119-t1x9gknd 10833 7 appropriate appropriate JJ cord-010119-t1x9gknd 10833 8 education education NN cord-010119-t1x9gknd 10833 9 to to IN cord-010119-t1x9gknd 10833 10 healthcare healthcare NN cord-010119-t1x9gknd 10833 11 professionals professional NNS cord-010119-t1x9gknd 10833 12 . . . cord-010119-t1x9gknd 10834 1 This this DT cord-010119-t1x9gknd 10834 2 score score NN cord-010119-t1x9gknd 10834 3 has have VBZ cord-010119-t1x9gknd 10834 4 increased increase VBN cord-010119-t1x9gknd 10834 5 2011 2011 CD cord-010119-t1x9gknd 10834 6 - - SYM cord-010119-t1x9gknd 10834 7 2016 2016 CD cord-010119-t1x9gknd 10834 8 from from IN cord-010119-t1x9gknd 10834 9 8.4 8.4 CD cord-010119-t1x9gknd 10834 10 to to IN cord-010119-t1x9gknd 10834 11 9.0 9.0 CD cord-010119-t1x9gknd 10834 12 . . . cord-010119-t1x9gknd 10835 1 Conclusion conclusion NN cord-010119-t1x9gknd 10835 2 : : : cord-010119-t1x9gknd 10835 3 Feedback Feedback NNP cord-010119-t1x9gknd 10835 4 , , , cord-010119-t1x9gknd 10835 5 NPS NPS NNP cord-010119-t1x9gknd 10835 6 scores score NNS cord-010119-t1x9gknd 10835 7 and and CC cord-010119-t1x9gknd 10835 8 surveys survey NNS cord-010119-t1x9gknd 10835 9 ensure ensure VBP cord-010119-t1x9gknd 10835 10 that that IN cord-010119-t1x9gknd 10835 11 education education NN cord-010119-t1x9gknd 10835 12 and and CC cord-010119-t1x9gknd 10835 13 training training NN cord-010119-t1x9gknd 10835 14 program program NN cord-010119-t1x9gknd 10835 15 of of IN cord-010119-t1x9gknd 10835 16 FRCBS FRCBS NNP cord-010119-t1x9gknd 10835 17 responses response NNS cord-010119-t1x9gknd 10835 18 to to IN cord-010119-t1x9gknd 10835 19 customer customer NN cord-010119-t1x9gknd 10835 20 needs need NNS cord-010119-t1x9gknd 10835 21 . . . cord-010119-t1x9gknd 10836 1 Hospitals hospital NNS cord-010119-t1x9gknd 10836 2 can can MD cord-010119-t1x9gknd 10836 3 utilize utilize VB cord-010119-t1x9gknd 10836 4 annual annual JJ cord-010119-t1x9gknd 10836 5 courses course NNS cord-010119-t1x9gknd 10836 6 of of IN cord-010119-t1x9gknd 10836 7 FRCBS FRCBS NNP cord-010119-t1x9gknd 10836 8 in in IN cord-010119-t1x9gknd 10836 9 their -PRON- PRP$ cord-010119-t1x9gknd 10836 10 own own JJ cord-010119-t1x9gknd 10836 11 initiation initiation NN cord-010119-t1x9gknd 10836 12 programs program NNS cord-010119-t1x9gknd 10836 13 . . . cord-010119-t1x9gknd 10837 1 Together together RB cord-010119-t1x9gknd 10837 2 with with IN cord-010119-t1x9gknd 10837 3 clinical clinical JJ cord-010119-t1x9gknd 10837 4 contact contact NN cord-010119-t1x9gknd 10837 5 persons person NNS cord-010119-t1x9gknd 10837 6 in in IN cord-010119-t1x9gknd 10837 7 hospitals hospital NNS cord-010119-t1x9gknd 10837 8 our -PRON- PRP$ cord-010119-t1x9gknd 10837 9 aim aim NN cord-010119-t1x9gknd 10837 10 is be VBZ cord-010119-t1x9gknd 10837 11 to to TO cord-010119-t1x9gknd 10837 12 ensure ensure VB cord-010119-t1x9gknd 10837 13 Patient Patient NNP cord-010119-t1x9gknd 10837 14 Blood Blood NNP cord-010119-t1x9gknd 10837 15 Management Management NNP cord-010119-t1x9gknd 10837 16 ( ( -LRB- cord-010119-t1x9gknd 10837 17 PBM PBM NNP cord-010119-t1x9gknd 10837 18 ) ) -RRB- cord-010119-t1x9gknd 10837 19 and and CC cord-010119-t1x9gknd 10837 20 to to TO cord-010119-t1x9gknd 10837 21 optimize optimize VB cord-010119-t1x9gknd 10837 22 use use NN cord-010119-t1x9gknd 10837 23 of of IN cord-010119-t1x9gknd 10837 24 blood blood NN cord-010119-t1x9gknd 10837 25 products product NNS cord-010119-t1x9gknd 10837 26 . . . cord-010119-t1x9gknd 10838 1 We -PRON- PRP cord-010119-t1x9gknd 10838 2 also also RB cord-010119-t1x9gknd 10838 3 have have VBP cord-010119-t1x9gknd 10838 4 plans plan NNS cord-010119-t1x9gknd 10838 5 to to TO cord-010119-t1x9gknd 10838 6 increase increase VB cord-010119-t1x9gknd 10838 7 e e NN cord-010119-t1x9gknd 10838 8 - - HYPH cord-010119-t1x9gknd 10838 9 learning learn VBG cord-010119-t1x9gknd 10838 10 applications application NNS cord-010119-t1x9gknd 10838 11 and and CC cord-010119-t1x9gknd 10838 12 the the DT cord-010119-t1x9gknd 10838 13 courses course NNS cord-010119-t1x9gknd 10838 14 of of IN cord-010119-t1x9gknd 10838 15 transfusion transfusion NN cord-010119-t1x9gknd 10838 16 medicine medicine NN cord-010119-t1x9gknd 10838 17 for for IN cord-010119-t1x9gknd 10838 18 nurses nurse NNS cord-010119-t1x9gknd 10838 19 and and CC cord-010119-t1x9gknd 10838 20 medical medical JJ cord-010119-t1x9gknd 10838 21 students student NNS cord-010119-t1x9gknd 10838 22 . . . cord-010119-t1x9gknd 10839 1 Educational Educational NNP cord-010119-t1x9gknd 10839 2 Outreach Outreach NNP cord-010119-t1x9gknd 10839 3 and and CC cord-010119-t1x9gknd 10839 4 Effect Effect NNP cord-010119-t1x9gknd 10839 5 on on IN cord-010119-t1x9gknd 10839 6 Reporting Reporting NNP cord-010119-t1x9gknd 10839 7 Septic Septic NNP cord-010119-t1x9gknd 10839 8 Transfusion Transfusion NNP cord-010119-t1x9gknd 10839 9 Reactions reaction NNS cord-010119-t1x9gknd 10839 10 Kathleen Kathleen NNP cord-010119-t1x9gknd 10839 11 M M NNP cord-010119-t1x9gknd 10839 12 Grima Grima NNP cord-010119-t1x9gknd 10839 13 * * NFP cord-010119-t1x9gknd 10839 14 1 1 CD cord-010119-t1x9gknd 10839 15 , , , cord-010119-t1x9gknd 10839 16 Anne Anne NNP cord-010119-t1x9gknd 10839 17 Eder Eder NNP cord-010119-t1x9gknd 10839 18 2 2 CD cord-010119-t1x9gknd 10839 19 , , , cord-010119-t1x9gknd 10839 20 Beth Beth NNP cord-010119-t1x9gknd 10839 21 A. A. NNP cord-010119-t1x9gknd 10839 22 Dy Dy NNP cord-010119-t1x9gknd 10839 23 1 1 CD cord-010119-t1x9gknd 10839 24 and and CC cord-010119-t1x9gknd 10839 25 Mary Mary NNP cord-010119-t1x9gknd 10839 26 O'Neill O'Neill NNP cord-010119-t1x9gknd 10839 27 1 1 CD cord-010119-t1x9gknd 10839 28 . . . cord-010119-t1x9gknd 10839 29 1 1 CD cord-010119-t1x9gknd 10839 30 American American NNP cord-010119-t1x9gknd 10839 31 Red Red NNP cord-010119-t1x9gknd 10839 32 Cross Cross NNP cord-010119-t1x9gknd 10839 33 , , , cord-010119-t1x9gknd 10839 34 2 2 CD cord-010119-t1x9gknd 10839 35 Georgetown Georgetown NNP cord-010119-t1x9gknd 10839 36 University University NNP cord-010119-t1x9gknd 10839 37 Background Background NNP cord-010119-t1x9gknd 10839 38 / / SYM cord-010119-t1x9gknd 10839 39 Case Case NNP cord-010119-t1x9gknd 10839 40 Studies Studies NNPS cord-010119-t1x9gknd 10839 41 : : : cord-010119-t1x9gknd 10840 1 Hemovigilance Hemovigilance NNP cord-010119-t1x9gknd 10840 2 programs program NNS cord-010119-t1x9gknd 10840 3 to to TO cord-010119-t1x9gknd 10840 4 monitor monitor VB cord-010119-t1x9gknd 10840 5 adverse adverse JJ cord-010119-t1x9gknd 10840 6 events event NNS cord-010119-t1x9gknd 10840 7 after after IN cord-010119-t1x9gknd 10840 8 transfusion transfusion NN cord-010119-t1x9gknd 10840 9 depend depend VBP cord-010119-t1x9gknd 10840 10 on on IN cord-010119-t1x9gknd 10840 11 clinicians clinician NNS cord-010119-t1x9gknd 10840 12 ' ' POS cord-010119-t1x9gknd 10840 13 ability ability NN cord-010119-t1x9gknd 10840 14 to to TO cord-010119-t1x9gknd 10840 15 recognize recognize VB cord-010119-t1x9gknd 10840 16 and and CC cord-010119-t1x9gknd 10840 17 report report VB cord-010119-t1x9gknd 10840 18 reactions reaction NNS cord-010119-t1x9gknd 10840 19 to to IN cord-010119-t1x9gknd 10840 20 the the DT cord-010119-t1x9gknd 10840 21 blood blood NN cord-010119-t1x9gknd 10840 22 center center NN cord-010119-t1x9gknd 10840 23 . . . cord-010119-t1x9gknd 10841 1 About about RB cord-010119-t1x9gknd 10841 2 1 1 CD cord-010119-t1x9gknd 10841 3 in in IN cord-010119-t1x9gknd 10841 4 100,000 100,000 CD cord-010119-t1x9gknd 10841 5 apheresis apheresis NN cord-010119-t1x9gknd 10841 6 platelet platelet NN cord-010119-t1x9gknd 10841 7 donations donation NNS cord-010119-t1x9gknd 10841 8 are be VBP cord-010119-t1x9gknd 10841 9 implicated implicate VBN cord-010119-t1x9gknd 10841 10 in in IN cord-010119-t1x9gknd 10841 11 septic septic JJ cord-010119-t1x9gknd 10841 12 transfusion transfusion NN cord-010119-t1x9gknd 10841 13 reactions reaction NNS cord-010119-t1x9gknd 10841 14 ( ( -LRB- cord-010119-t1x9gknd 10841 15 STRs STRs NNPS cord-010119-t1x9gknd 10841 16 ) ) -RRB- cord-010119-t1x9gknd 10841 17 , , , cord-010119-t1x9gknd 10841 18 but but CC cord-010119-t1x9gknd 10841 19 this this DT cord-010119-t1x9gknd 10841 20 could could MD cord-010119-t1x9gknd 10841 21 underestimate underestimate VB cord-010119-t1x9gknd 10841 22 the the DT cord-010119-t1x9gknd 10841 23 risk risk NN cord-010119-t1x9gknd 10841 24 because because IN cord-010119-t1x9gknd 10841 25 of of IN cord-010119-t1x9gknd 10841 26 the the DT cord-010119-t1x9gknd 10841 27 difficulty difficulty NN cord-010119-t1x9gknd 10841 28 in in IN cord-010119-t1x9gknd 10841 29 recognizing recognize VBG cord-010119-t1x9gknd 10841 30 delayed delayed JJ cord-010119-t1x9gknd 10841 31 or or CC cord-010119-t1x9gknd 10841 32 mild mild JJ cord-010119-t1x9gknd 10841 33 reactions reaction NNS cord-010119-t1x9gknd 10841 34 . . . cord-010119-t1x9gknd 10842 1 A a DT cord-010119-t1x9gknd 10842 2 large large JJ cord-010119-t1x9gknd 10842 3 blood blood NN cord-010119-t1x9gknd 10842 4 center center NN cord-010119-t1x9gknd 10842 5 designed design VBD cord-010119-t1x9gknd 10842 6 an an DT cord-010119-t1x9gknd 10842 7 educational educational JJ cord-010119-t1x9gknd 10842 8 outreach outreach NN cord-010119-t1x9gknd 10842 9 program program NN cord-010119-t1x9gknd 10842 10 to to TO cord-010119-t1x9gknd 10842 11 increase increase VB cord-010119-t1x9gknd 10842 12 awareness awareness NN cord-010119-t1x9gknd 10842 13 of of IN cord-010119-t1x9gknd 10842 14 STRs str NNS cord-010119-t1x9gknd 10842 15 and and CC cord-010119-t1x9gknd 10842 16 assessed assess VBD cord-010119-t1x9gknd 10842 17 its -PRON- PRP$ cord-010119-t1x9gknd 10842 18 effect effect NN cord-010119-t1x9gknd 10842 19 on on IN cord-010119-t1x9gknd 10842 20 the the DT cord-010119-t1x9gknd 10842 21 rate rate NN cord-010119-t1x9gknd 10842 22 of of IN cord-010119-t1x9gknd 10842 23 STR STR NNP cord-010119-t1x9gknd 10842 24 reporting report VBG cord-010119-t1x9gknd 10842 25 to to IN cord-010119-t1x9gknd 10842 26 its -PRON- PRP$ cord-010119-t1x9gknd 10842 27 national national JJ cord-010119-t1x9gknd 10842 28 hemovigilance hemovigilance NN cord-010119-t1x9gknd 10842 29 program program NN cord-010119-t1x9gknd 10842 30 . . . cord-010119-t1x9gknd 10843 1 Study Study NNP cord-010119-t1x9gknd 10843 2 Design Design NNP cord-010119-t1x9gknd 10843 3 / / SYM cord-010119-t1x9gknd 10843 4 Method method NN cord-010119-t1x9gknd 10843 5 : : : cord-010119-t1x9gknd 10843 6 In in IN cord-010119-t1x9gknd 10843 7 Dec. December NNP cord-010119-t1x9gknd 10843 8 2015 2015 CD cord-010119-t1x9gknd 10843 9 , , , cord-010119-t1x9gknd 10843 10 a a DT cord-010119-t1x9gknd 10843 11 large large JJ cord-010119-t1x9gknd 10843 12 blood blood NN cord-010119-t1x9gknd 10843 13 center center NN cord-010119-t1x9gknd 10843 14 developed develop VBD cord-010119-t1x9gknd 10843 15 a a DT cord-010119-t1x9gknd 10843 16 web web NN cord-010119-t1x9gknd 10843 17 based base VBN cord-010119-t1x9gknd 10843 18 course course NN cord-010119-t1x9gknd 10843 19 on on IN cord-010119-t1x9gknd 10843 20 STRs str NNS cord-010119-t1x9gknd 10843 21 for for IN cord-010119-t1x9gknd 10843 22 CME CME NNP cord-010119-t1x9gknd 10843 23 / / SYM cord-010119-t1x9gknd 10843 24 CEU CEU NNP cord-010119-t1x9gknd 10843 25 credit credit NN cord-010119-t1x9gknd 10843 26 . . . cord-010119-t1x9gknd 10844 1 Letters letter NNS cord-010119-t1x9gknd 10844 2 were be VBD cord-010119-t1x9gknd 10844 3 sent send VBN cord-010119-t1x9gknd 10844 4 to to IN cord-010119-t1x9gknd 10844 5 2,300 2,300 CD cord-010119-t1x9gknd 10844 6 hospital hospital NN cord-010119-t1x9gknd 10844 7 customers customer NNS cord-010119-t1x9gknd 10844 8 about about IN cord-010119-t1x9gknd 10844 9 recognizing recognize VBG cord-010119-t1x9gknd 10844 10 and and CC cord-010119-t1x9gknd 10844 11 reporting report VBG cord-010119-t1x9gknd 10844 12 STRs str NNS cord-010119-t1x9gknd 10844 13 , , , cord-010119-t1x9gknd 10844 14 and and CC cord-010119-t1x9gknd 10844 15 alerting alert VBG cord-010119-t1x9gknd 10844 16 them -PRON- PRP cord-010119-t1x9gknd 10844 17 to to IN cord-010119-t1x9gknd 10844 18 the the DT cord-010119-t1x9gknd 10844 19 availability availability NN cord-010119-t1x9gknd 10844 20 of of IN cord-010119-t1x9gknd 10844 21 the the DT cord-010119-t1x9gknd 10844 22 course course NN cord-010119-t1x9gknd 10844 23 . . . cord-010119-t1x9gknd 10845 1 Blood blood NN cord-010119-t1x9gknd 10845 2 center center NN cord-010119-t1x9gknd 10845 3 physicians physician NNS cord-010119-t1x9gknd 10845 4 and and CC cord-010119-t1x9gknd 10845 5 staff staff NN cord-010119-t1x9gknd 10845 6 in in IN cord-010119-t1x9gknd 10845 7 sales sale NNS cord-010119-t1x9gknd 10845 8 and and CC cord-010119-t1x9gknd 10845 9 marketing marketing NN cord-010119-t1x9gknd 10845 10 also also RB cord-010119-t1x9gknd 10845 11 engaged engage VBD cord-010119-t1x9gknd 10845 12 hospital hospital NN cord-010119-t1x9gknd 10845 13 customers customer NNS cord-010119-t1x9gknd 10845 14 directly directly RB cord-010119-t1x9gknd 10845 15 in in IN cord-010119-t1x9gknd 10845 16 discussions discussion NNS cord-010119-t1x9gknd 10845 17 about about IN cord-010119-t1x9gknd 10845 18 recognizing recognize VBG cord-010119-t1x9gknd 10845 19 and and CC cord-010119-t1x9gknd 10845 20 reporting report VBG cord-010119-t1x9gknd 10845 21 STRs str NNS cord-010119-t1x9gknd 10845 22 , , , cord-010119-t1x9gknd 10845 23 using use VBG cord-010119-t1x9gknd 10845 24 the the DT cord-010119-t1x9gknd 10845 25 online online JJ cord-010119-t1x9gknd 10845 26 educational educational JJ cord-010119-t1x9gknd 10845 27 content content NN cord-010119-t1x9gknd 10845 28 . . . cord-010119-t1x9gknd 10846 1 The the DT cord-010119-t1x9gknd 10846 2 physicians physician NNS cord-010119-t1x9gknd 10846 3 tracked track VBD cord-010119-t1x9gknd 10846 4 their -PRON- PRP$ cord-010119-t1x9gknd 10846 5 interactions interaction NNS cord-010119-t1x9gknd 10846 6 . . . cord-010119-t1x9gknd 10847 1 The the DT cord-010119-t1x9gknd 10847 2 blood blood NN cord-010119-t1x9gknd 10847 3 center center NN cord-010119-t1x9gknd 10847 4 's 's POS cord-010119-t1x9gknd 10847 5 national national JJ cord-010119-t1x9gknd 10847 6 hemovigilance hemovigilance NN cord-010119-t1x9gknd 10847 7 program program NN cord-010119-t1x9gknd 10847 8 compared compare VBD cord-010119-t1x9gknd 10847 9 the the DT cord-010119-t1x9gknd 10847 10 number number NN cord-010119-t1x9gknd 10847 11 of of IN cord-010119-t1x9gknd 10847 12 STRs STRs NNPS cord-010119-t1x9gknd 10847 13 reported report VBN cord-010119-t1x9gknd 10847 14 in in IN cord-010119-t1x9gknd 10847 15 the the DT cord-010119-t1x9gknd 10847 16 12 12 CD cord-010119-t1x9gknd 10847 17 months month NNS cord-010119-t1x9gknd 10847 18 before before IN cord-010119-t1x9gknd 10847 19 and and CC cord-010119-t1x9gknd 10847 20 after after IN cord-010119-t1x9gknd 10847 21 launching launch VBG cord-010119-t1x9gknd 10847 22 the the DT cord-010119-t1x9gknd 10847 23 educational educational JJ cord-010119-t1x9gknd 10847 24 outreach outreach NN cord-010119-t1x9gknd 10847 25 . . . cord-010119-t1x9gknd 10848 1 Results/ Results/ . cord-010119-t1x9gknd 10849 1 Finding finding NN cord-010119-t1x9gknd 10849 2 : : : cord-010119-t1x9gknd 10850 1 The the DT cord-010119-t1x9gknd 10850 2 web web NN cord-010119-t1x9gknd 10850 3 based base VBN cord-010119-t1x9gknd 10850 4 course course NN cord-010119-t1x9gknd 10850 5 was be VBD cord-010119-t1x9gknd 10850 6 completed complete VBN cord-010119-t1x9gknd 10850 7 by by IN cord-010119-t1x9gknd 10850 8 more more JJR cord-010119-t1x9gknd 10850 9 than than IN cord-010119-t1x9gknd 10850 10 700 700 CD cord-010119-t1x9gknd 10850 11 participants participant NNS cord-010119-t1x9gknd 10850 12 ; ; : cord-010119-t1x9gknd 10850 13 117 117 CD cord-010119-t1x9gknd 10850 14 were be VBD cord-010119-t1x9gknd 10850 15 physicians physician NNS cord-010119-t1x9gknd 10850 16 . . . cord-010119-t1x9gknd 10851 1 Based base VBN cord-010119-t1x9gknd 10851 2 on on IN cord-010119-t1x9gknd 10851 3 a a DT cord-010119-t1x9gknd 10851 4 review review NN cord-010119-t1x9gknd 10851 5 of of IN cord-010119-t1x9gknd 10851 6 the the DT cord-010119-t1x9gknd 10851 7 evaluations evaluation NNS cord-010119-t1x9gknd 10851 8 , , , cord-010119-t1x9gknd 10851 9 the the DT cord-010119-t1x9gknd 10851 10 course course NN cord-010119-t1x9gknd 10851 11 was be VBD cord-010119-t1x9gknd 10851 12 highly highly RB cord-010119-t1x9gknd 10851 13 valued value VBN cord-010119-t1x9gknd 10851 14 with with IN cord-010119-t1x9gknd 10851 15 93 93 CD cord-010119-t1x9gknd 10851 16 % % NN cord-010119-t1x9gknd 10851 17 of of IN cord-010119-t1x9gknd 10851 18 participants participant NNS cord-010119-t1x9gknd 10851 19 rating rate VBG cord-010119-t1x9gknd 10851 20 it -PRON- PRP cord-010119-t1x9gknd 10851 21 excellent excellent JJ cord-010119-t1x9gknd 10851 22 or or CC cord-010119-t1x9gknd 10851 23 very very RB cord-010119-t1x9gknd 10851 24 good good JJ cord-010119-t1x9gknd 10851 25 . . . cord-010119-t1x9gknd 10852 1 The the DT cord-010119-t1x9gknd 10852 2 blood blood NN cord-010119-t1x9gknd 10852 3 center center NN cord-010119-t1x9gknd 10852 4 physicians physician NNS cord-010119-t1x9gknd 10852 5 gave give VBD cord-010119-t1x9gknd 10852 6 over over RP cord-010119-t1x9gknd 10852 7 200 200 CD cord-010119-t1x9gknd 10852 8 presentations presentation NNS cord-010119-t1x9gknd 10852 9 to to IN cord-010119-t1x9gknd 10852 10 hospital hospital NN cord-010119-t1x9gknd 10852 11 customers customer NNS cord-010119-t1x9gknd 10852 12 . . . cord-010119-t1x9gknd 10853 1 Reporting report VBG cord-010119-t1x9gknd 10853 2 of of IN cord-010119-t1x9gknd 10853 3 suspected suspect VBN cord-010119-t1x9gknd 10853 4 STRs str NNS cord-010119-t1x9gknd 10853 5 in in IN cord-010119-t1x9gknd 10853 6 2016 2016 CD cord-010119-t1x9gknd 10853 7 increased increase VBN cord-010119-t1x9gknd 10853 8 by by IN cord-010119-t1x9gknd 10853 9 23 23 CD cord-010119-t1x9gknd 10853 10 % % NN cord-010119-t1x9gknd 10853 11 compared compare VBN cord-010119-t1x9gknd 10853 12 to to IN cord-010119-t1x9gknd 10853 13 the the DT cord-010119-t1x9gknd 10853 14 prior prior JJ cord-010119-t1x9gknd 10853 15 year year NN cord-010119-t1x9gknd 10853 16 . . . cord-010119-t1x9gknd 10854 1 The the DT cord-010119-t1x9gknd 10854 2 increased increased JJ cord-010119-t1x9gknd 10854 3 reporting reporting NN cord-010119-t1x9gknd 10854 4 came come VBD cord-010119-t1x9gknd 10854 5 from from IN cord-010119-t1x9gknd 10854 6 2 2 CD cord-010119-t1x9gknd 10854 7 specific specific JJ cord-010119-t1x9gknd 10854 8 regions region NNS cord-010119-t1x9gknd 10854 9 . . . cord-010119-t1x9gknd 10855 1 The the DT cord-010119-t1x9gknd 10855 2 total total JJ cord-010119-t1x9gknd 10855 3 number number NN cord-010119-t1x9gknd 10855 4 of of IN cord-010119-t1x9gknd 10855 5 STRs str NNS cord-010119-t1x9gknd 10855 6 that that WDT cord-010119-t1x9gknd 10855 7 met meet VBD cord-010119-t1x9gknd 10855 8 the the DT cord-010119-t1x9gknd 10855 9 hemovigilance hemovigilance NN cord-010119-t1x9gknd 10855 10 definitions definition NNS cord-010119-t1x9gknd 10855 11 for for IN cord-010119-t1x9gknd 10855 12 definite definite JJ cord-010119-t1x9gknd 10855 13 ( ( -LRB- cord-010119-t1x9gknd 10855 14 culture culture NN cord-010119-t1x9gknd 10855 15 - - HYPH cord-010119-t1x9gknd 10855 16 confirmed confirm VBN cord-010119-t1x9gknd 10855 17 ) ) -RRB- cord-010119-t1x9gknd 10855 18 and and CC cord-010119-t1x9gknd 10855 19 probable probable JJ cord-010119-t1x9gknd 10855 20 STRs str NNS cord-010119-t1x9gknd 10855 21 in in IN cord-010119-t1x9gknd 10855 22 the the DT cord-010119-t1x9gknd 10855 23 nationwide nationwide JJ cord-010119-t1x9gknd 10855 24 system system NN cord-010119-t1x9gknd 10855 25 increased increase VBD cord-010119-t1x9gknd 10855 26 but but CC cord-010119-t1x9gknd 10855 27 did do VBD cord-010119-t1x9gknd 10855 28 not not RB cord-010119-t1x9gknd 10855 29 change change VB cord-010119-t1x9gknd 10855 30 significantly significantly RB cord-010119-t1x9gknd 10855 31 compared compare VBN cord-010119-t1x9gknd 10855 32 to to IN cord-010119-t1x9gknd 10855 33 the the DT cord-010119-t1x9gknd 10855 34 previous previous JJ cord-010119-t1x9gknd 10855 35 years year NNS cord-010119-t1x9gknd 10855 36 . . . cord-010119-t1x9gknd 10856 1 The the DT cord-010119-t1x9gknd 10856 2 educational educational JJ cord-010119-t1x9gknd 10856 3 initiative initiative NN cord-010119-t1x9gknd 10856 4 was be VBD cord-010119-t1x9gknd 10856 5 designed design VBN cord-010119-t1x9gknd 10856 6 to to TO cord-010119-t1x9gknd 10856 7 deliver deliver VB cord-010119-t1x9gknd 10856 8 a a DT cord-010119-t1x9gknd 10856 9 consistent consistent JJ cord-010119-t1x9gknd 10856 10 message message NN cord-010119-t1x9gknd 10856 11 on on IN cord-010119-t1x9gknd 10856 12 the the DT cord-010119-t1x9gknd 10856 13 risks risk NNS cord-010119-t1x9gknd 10856 14 , , , cord-010119-t1x9gknd 10856 15 recognition recognition NN cord-010119-t1x9gknd 10856 16 and and CC cord-010119-t1x9gknd 10856 17 reporting reporting NN cord-010119-t1x9gknd 10856 18 of of IN cord-010119-t1x9gknd 10856 19 STRs STRs NNPS cord-010119-t1x9gknd 10856 20 . . . cord-010119-t1x9gknd 10857 1 While while IN cord-010119-t1x9gknd 10857 2 the the DT cord-010119-t1x9gknd 10857 3 number number NN cord-010119-t1x9gknd 10857 4 of of IN cord-010119-t1x9gknd 10857 5 reports report NNS cord-010119-t1x9gknd 10857 6 of of IN cord-010119-t1x9gknd 10857 7 suspected suspect VBN cord-010119-t1x9gknd 10857 8 STRs str NNS cord-010119-t1x9gknd 10857 9 in in IN cord-010119-t1x9gknd 10857 10 two two CD cord-010119-t1x9gknd 10857 11 regions region NNS cord-010119-t1x9gknd 10857 12 increased increase VBD cord-010119-t1x9gknd 10857 13 , , , cord-010119-t1x9gknd 10857 14 there there EX cord-010119-t1x9gknd 10857 15 was be VBD cord-010119-t1x9gknd 10857 16 no no DT cord-010119-t1x9gknd 10857 17 meaningful meaningful JJ cord-010119-t1x9gknd 10857 18 change change NN cord-010119-t1x9gknd 10857 19 in in IN cord-010119-t1x9gknd 10857 20 the the DT cord-010119-t1x9gknd 10857 21 overall overall JJ cord-010119-t1x9gknd 10857 22 reporting reporting NN cord-010119-t1x9gknd 10857 23 of of IN cord-010119-t1x9gknd 10857 24 suspected suspect VBN cord-010119-t1x9gknd 10857 25 or or CC cord-010119-t1x9gknd 10857 26 confirmed confirm VBN cord-010119-t1x9gknd 10857 27 STRs str NNS cord-010119-t1x9gknd 10857 28 across across IN cord-010119-t1x9gknd 10857 29 the the DT cord-010119-t1x9gknd 10857 30 national national JJ cord-010119-t1x9gknd 10857 31 blood blood NN cord-010119-t1x9gknd 10857 32 system system NN cord-010119-t1x9gknd 10857 33 . . . cord-010119-t1x9gknd 10858 1 This this DT cord-010119-t1x9gknd 10858 2 finding finding NN cord-010119-t1x9gknd 10858 3 could could MD cord-010119-t1x9gknd 10858 4 reflect reflect VB cord-010119-t1x9gknd 10858 5 that that IN cord-010119-t1x9gknd 10858 6 hospitals hospital NNS cord-010119-t1x9gknd 10858 7 already already RB cord-010119-t1x9gknd 10858 8 recognize recognize VBP cord-010119-t1x9gknd 10858 9 and and CC cord-010119-t1x9gknd 10858 10 report report VB cord-010119-t1x9gknd 10858 11 medically medically RB cord-010119-t1x9gknd 10858 12 significant significant JJ cord-010119-t1x9gknd 10858 13 reactions reaction NNS cord-010119-t1x9gknd 10858 14 or or CC cord-010119-t1x9gknd 10858 15 that that IN cord-010119-t1x9gknd 10858 16 the the DT cord-010119-t1x9gknd 10858 17 target target NN cord-010119-t1x9gknd 10858 18 audience audience NN cord-010119-t1x9gknd 10858 19 was be VBD cord-010119-t1x9gknd 10858 20 laboratory laboratory NN cord-010119-t1x9gknd 10858 21 personnel personnel NNS cord-010119-t1x9gknd 10858 22 and and CC cord-010119-t1x9gknd 10858 23 physicians physician NNS cord-010119-t1x9gknd 10858 24 in in IN cord-010119-t1x9gknd 10858 25 transfusion transfusion NN cord-010119-t1x9gknd 10858 26 medicine medicine NN cord-010119-t1x9gknd 10858 27 , , , cord-010119-t1x9gknd 10858 28 but but CC cord-010119-t1x9gknd 10858 29 not not RB cord-010119-t1x9gknd 10858 30 the the DT cord-010119-t1x9gknd 10858 31 clinicians clinician NNS cord-010119-t1x9gknd 10858 32 closest close JJS cord-010119-t1x9gknd 10858 33 to to TO cord-010119-t1x9gknd 10858 34 patient patient JJ cord-010119-t1x9gknd 10858 35 care care NN cord-010119-t1x9gknd 10858 36 at at IN cord-010119-t1x9gknd 10858 37 the the DT cord-010119-t1x9gknd 10858 38 bedside bedside NN cord-010119-t1x9gknd 10858 39 . . . cord-010119-t1x9gknd 10859 1 More more RBR cord-010119-t1x9gknd 10859 2 targeted target VBN cord-010119-t1x9gknd 10859 3 educational educational JJ cord-010119-t1x9gknd 10859 4 efforts effort NNS cord-010119-t1x9gknd 10859 5 provided provide VBN cord-010119-t1x9gknd 10859 6 by by IN cord-010119-t1x9gknd 10859 7 personnel personnel NNS cord-010119-t1x9gknd 10859 8 who who WP cord-010119-t1x9gknd 10859 9 interface interface VBP cord-010119-t1x9gknd 10859 10 with with IN cord-010119-t1x9gknd 10859 11 hospitals hospital NNS cord-010119-t1x9gknd 10859 12 could could MD cord-010119-t1x9gknd 10859 13 be be VB cord-010119-t1x9gknd 10859 14 used use VBN cord-010119-t1x9gknd 10859 15 to to TO cord-010119-t1x9gknd 10859 16 address address VB cord-010119-t1x9gknd 10859 17 identified identify VBN cord-010119-t1x9gknd 10859 18 professional professional JJ cord-010119-t1x9gknd 10859 19 practice practice NN cord-010119-t1x9gknd 10859 20 gaps gap NNS cord-010119-t1x9gknd 10859 21 in in IN cord-010119-t1x9gknd 10859 22 transfusion transfusion NN cord-010119-t1x9gknd 10859 23 medicine medicine NN cord-010119-t1x9gknd 10859 24 . . . cord-010119-t1x9gknd 10860 1 Implementation implementation NN cord-010119-t1x9gknd 10860 2 of of IN cord-010119-t1x9gknd 10860 3 Subscription Subscription NNP cord-010119-t1x9gknd 10860 4 - - HYPH cord-010119-t1x9gknd 10860 5 Based base VBN cord-010119-t1x9gknd 10860 6 cGMP cGMP NNP cord-010119-t1x9gknd 10860 7 e e NN cord-010119-t1x9gknd 10860 8 - - : cord-010119-t1x9gknd 10860 9 Learning Learning NNP cord-010119-t1x9gknd 10860 10 Laurie Laurie NNP cord-010119-t1x9gknd 10860 11 McGraw McGraw NNP cord-010119-t1x9gknd 10860 12 * * NFP cord-010119-t1x9gknd 10860 13 , , , cord-010119-t1x9gknd 10860 14 Courtney Courtney NNP cord-010119-t1x9gknd 10860 15 Saphier Saphier NNP cord-010119-t1x9gknd 10860 16 , , , cord-010119-t1x9gknd 10860 17 Helene Helene NNP cord-010119-t1x9gknd 10860 18 Belton Belton NNP cord-010119-t1x9gknd 10860 19 , , , cord-010119-t1x9gknd 10860 20 Sallie Sallie NNP cord-010119-t1x9gknd 10860 21 Bittner Bittner NNP cord-010119-t1x9gknd 10860 22 and and CC cord-010119-t1x9gknd 10860 23 Ward Ward NNP cord-010119-t1x9gknd 10860 24 Scott Scott NNP cord-010119-t1x9gknd 10860 25 . . . cord-010119-t1x9gknd 10861 1 Gulf Gulf NNP cord-010119-t1x9gknd 10861 2 Coast Coast NNP cord-010119-t1x9gknd 10861 3 Regional Regional NNP cord-010119-t1x9gknd 10861 4 Blood Blood NNP cord-010119-t1x9gknd 10861 5 Center Center NNP cord-010119-t1x9gknd 10861 6 Background Background NNP cord-010119-t1x9gknd 10861 7 / / SYM cord-010119-t1x9gknd 10861 8 Case Case NNP cord-010119-t1x9gknd 10861 9 Studies Studies NNPS cord-010119-t1x9gknd 10861 10 : : : cord-010119-t1x9gknd 10861 11 Previous previous JJ cord-010119-t1x9gknd 10861 12 cGMP cGMP NNP cord-010119-t1x9gknd 10861 13 e e NN cord-010119-t1x9gknd 10861 14 - - JJ cord-010119-t1x9gknd 10861 15 learning learn VBG cord-010119-t1x9gknd 10861 16 courses course NNS cord-010119-t1x9gknd 10861 17 we -PRON- PRP cord-010119-t1x9gknd 10861 18 developed develop VBD cord-010119-t1x9gknd 10861 19 required require VBN cord-010119-t1x9gknd 10861 20 30 30 CD cord-010119-t1x9gknd 10861 21 - - SYM cord-010119-t1x9gknd 10861 22 45 45 CD cord-010119-t1x9gknd 10861 23 minutes minute NNS cord-010119-t1x9gknd 10861 24 for for IN cord-010119-t1x9gknd 10861 25 learners learner NNS cord-010119-t1x9gknd 10861 26 to to TO cord-010119-t1x9gknd 10861 27 complete complete VB cord-010119-t1x9gknd 10861 28 . . . cord-010119-t1x9gknd 10862 1 While while IN cord-010119-t1x9gknd 10862 2 feedback feedback NN cord-010119-t1x9gknd 10862 3 was be VBD cord-010119-t1x9gknd 10862 4 positive positive JJ cord-010119-t1x9gknd 10862 5 , , , cord-010119-t1x9gknd 10862 6 manufacturing manufacturing NN cord-010119-t1x9gknd 10862 7 areas area NNS cord-010119-t1x9gknd 10862 8 struggled struggle VBD cord-010119-t1x9gknd 10862 9 to to TO cord-010119-t1x9gknd 10862 10 schedule schedule NN cord-010119-t1x9gknd 10862 11 time time NN cord-010119-t1x9gknd 10862 12 for for IN cord-010119-t1x9gknd 10862 13 staff staff NN cord-010119-t1x9gknd 10862 14 to to TO cord-010119-t1x9gknd 10862 15 complete complete VB cord-010119-t1x9gknd 10862 16 courses course NNS cord-010119-t1x9gknd 10862 17 within within IN cord-010119-t1x9gknd 10862 18 their -PRON- PRP$ cord-010119-t1x9gknd 10862 19 assigned assign VBN cord-010119-t1x9gknd 10862 20 schedules schedule NNS cord-010119-t1x9gknd 10862 21 . . . cord-010119-t1x9gknd 10863 1 At at IN cord-010119-t1x9gknd 10863 2 the the DT cord-010119-t1x9gknd 10863 3 same same JJ cord-010119-t1x9gknd 10863 4 time time NN cord-010119-t1x9gknd 10863 5 , , , cord-010119-t1x9gknd 10863 6 a a DT cord-010119-t1x9gknd 10863 7 shift shift NN cord-010119-t1x9gknd 10863 8 in in IN cord-010119-t1x9gknd 10863 9 design design NN cord-010119-t1x9gknd 10863 10 trends trend NNS cord-010119-t1x9gknd 10863 11 suggest suggest VBP cord-010119-t1x9gknd 10863 12 that that IN cord-010119-t1x9gknd 10863 13 subscription subscription NN cord-010119-t1x9gknd 10863 14 - - HYPH cord-010119-t1x9gknd 10863 15 based base VBN cord-010119-t1x9gknd 10863 16 learning learning NN cord-010119-t1x9gknd 10863 17 is be VBZ cord-010119-t1x9gknd 10863 18 more more RBR cord-010119-t1x9gknd 10863 19 effective effective JJ cord-010119-t1x9gknd 10863 20 ( ( -LRB- cord-010119-t1x9gknd 10863 21 Thalheimer Thalheimer NNP cord-010119-t1x9gknd 10863 22 , , , cord-010119-t1x9gknd 10863 23 2014 2014 CD cord-010119-t1x9gknd 10863 24 . . . cord-010119-t1x9gknd 10863 25 ) ) -RRB- cord-010119-t1x9gknd 10864 1 Subscription subscription NN cord-010119-t1x9gknd 10864 2 - - HYPH cord-010119-t1x9gknd 10864 3 based base VBN cord-010119-t1x9gknd 10864 4 e e NN cord-010119-t1x9gknd 10864 5 - - NN cord-010119-t1x9gknd 10864 6 learning learning NN cord-010119-t1x9gknd 10864 7 utilizes utilize VBZ cord-010119-t1x9gknd 10864 8 5 5 CD cord-010119-t1x9gknd 10864 9 - - SYM cord-010119-t1x9gknd 10864 10 7 7 CD cord-010119-t1x9gknd 10864 11 minute minute NN cord-010119-t1x9gknd 10864 12 modules module NNS cord-010119-t1x9gknd 10864 13 , , , cord-010119-t1x9gknd 10864 14 delivered deliver VBN cord-010119-t1x9gknd 10864 15 at at IN cord-010119-t1x9gknd 10864 16 regular regular JJ cord-010119-t1x9gknd 10864 17 intervals interval NNS cord-010119-t1x9gknd 10864 18 . . . cord-010119-t1x9gknd 10865 1 This this DT cord-010119-t1x9gknd 10865 2 changes change VBZ cord-010119-t1x9gknd 10865 3 the the DT cord-010119-t1x9gknd 10865 4 learning learning NN cord-010119-t1x9gknd 10865 5 process process NN cord-010119-t1x9gknd 10865 6 from from IN cord-010119-t1x9gknd 10865 7 a a DT cord-010119-t1x9gknd 10865 8 singular singular JJ cord-010119-t1x9gknd 10865 9 event event NN cord-010119-t1x9gknd 10865 10 to to IN cord-010119-t1x9gknd 10865 11 a a DT cord-010119-t1x9gknd 10865 12 regular regular JJ cord-010119-t1x9gknd 10865 13 interaction interaction NN cord-010119-t1x9gknd 10865 14 that that WDT cord-010119-t1x9gknd 10865 15 reinforces reinforce VBZ cord-010119-t1x9gknd 10865 16 learning learn VBG cord-010119-t1x9gknd 10865 17 and and CC cord-010119-t1x9gknd 10865 18 keeps keep VBZ cord-010119-t1x9gknd 10865 19 the the DT cord-010119-t1x9gknd 10865 20 content content NN cord-010119-t1x9gknd 10865 21 at at IN cord-010119-t1x9gknd 10865 22 the the DT cord-010119-t1x9gknd 10865 23 top top NN cord-010119-t1x9gknd 10865 24 of of IN cord-010119-t1x9gknd 10865 25 the the DT cord-010119-t1x9gknd 10865 26 learner learner NN cord-010119-t1x9gknd 10865 27 's 's POS cord-010119-t1x9gknd 10865 28 mind mind NN cord-010119-t1x9gknd 10865 29 . . . cord-010119-t1x9gknd 10866 1 Study Study NNP cord-010119-t1x9gknd 10866 2 Design Design NNP cord-010119-t1x9gknd 10866 3 / / SYM cord-010119-t1x9gknd 10866 4 Method method NN cord-010119-t1x9gknd 10866 5 : : : cord-010119-t1x9gknd 10866 6 We -PRON- PRP cord-010119-t1x9gknd 10866 7 began begin VBD cord-010119-t1x9gknd 10866 8 developing develop VBG cord-010119-t1x9gknd 10866 9 cGMP cGMP NNP cord-010119-t1x9gknd 10866 10 subscription subscription NN cord-010119-t1x9gknd 10866 11 - - HYPH cord-010119-t1x9gknd 10866 12 based base VBN cord-010119-t1x9gknd 10866 13 elearning elearning NN cord-010119-t1x9gknd 10866 14 in in IN cord-010119-t1x9gknd 10866 15 2016 2016 CD cord-010119-t1x9gknd 10866 16 by by IN cord-010119-t1x9gknd 10866 17 selecting select VBG cord-010119-t1x9gknd 10866 18 our -PRON- PRP$ cord-010119-t1x9gknd 10866 19 first first JJ cord-010119-t1x9gknd 10866 20 five five CD cord-010119-t1x9gknd 10866 21 series series NN cord-010119-t1x9gknd 10866 22 topics topic NNS cord-010119-t1x9gknd 10866 23 : : : cord-010119-t1x9gknd 10866 24 Equipment equipment NN cord-010119-t1x9gknd 10866 25 , , , cord-010119-t1x9gknd 10866 26 Personnel Personnel NNP cord-010119-t1x9gknd 10866 27 , , , cord-010119-t1x9gknd 10866 28 Labeling labeling NN cord-010119-t1x9gknd 10866 29 , , , cord-010119-t1x9gknd 10866 30 SOPs sop NNS cord-010119-t1x9gknd 10866 31 , , , cord-010119-t1x9gknd 10866 32 and and CC cord-010119-t1x9gknd 10866 33 Records Records NNPS cord-010119-t1x9gknd 10866 34 . . . cord-010119-t1x9gknd 10867 1 The the DT cord-010119-t1x9gknd 10867 2 first first JJ cord-010119-t1x9gknd 10867 3 topic topic NN cord-010119-t1x9gknd 10867 4 , , , cord-010119-t1x9gknd 10867 5 Equipment Equipment NNP cord-010119-t1x9gknd 10867 6 , , , cord-010119-t1x9gknd 10867 7 was be VBD cord-010119-t1x9gknd 10867 8 divided divide VBN cord-010119-t1x9gknd 10867 9 into into IN cord-010119-t1x9gknd 10867 10 modules module NNS cord-010119-t1x9gknd 10867 11 on on IN cord-010119-t1x9gknd 10867 12 Selection Selection NNP cord-010119-t1x9gknd 10867 13 , , , cord-010119-t1x9gknd 10867 14 Validation Validation NNP cord-010119-t1x9gknd 10867 15 , , , cord-010119-t1x9gknd 10867 16 Calibration Calibration NNP cord-010119-t1x9gknd 10867 17 , , , cord-010119-t1x9gknd 10867 18 Quality Quality NNP cord-010119-t1x9gknd 10867 19 Control Control NNP cord-010119-t1x9gknd 10867 20 , , , cord-010119-t1x9gknd 10867 21 and and CC cord-010119-t1x9gknd 10867 22 Maintenance Maintenance NNP cord-010119-t1x9gknd 10867 23 . . . cord-010119-t1x9gknd 10868 1 These these DT cord-010119-t1x9gknd 10868 2 modules module NNS cord-010119-t1x9gknd 10868 3 , , , cord-010119-t1x9gknd 10868 4 and and CC cord-010119-t1x9gknd 10868 5 pre pre JJ cord-010119-t1x9gknd 10868 6 - - JJ cord-010119-t1x9gknd 10868 7 and and CC cord-010119-t1x9gknd 10868 8 post post NN cord-010119-t1x9gknd 10868 9 - - NNS cord-010119-t1x9gknd 10868 10 quizzes quiz NNS cord-010119-t1x9gknd 10868 11 for for IN cord-010119-t1x9gknd 10868 12 the the DT cord-010119-t1x9gknd 10868 13 Equipment Equipment NNP cord-010119-t1x9gknd 10868 14 series series NN cord-010119-t1x9gknd 10868 15 , , , cord-010119-t1x9gknd 10868 16 were be VBD cord-010119-t1x9gknd 10868 17 developed develop VBN cord-010119-t1x9gknd 10868 18 and and CC cord-010119-t1x9gknd 10868 19 assigned assign VBN cord-010119-t1x9gknd 10868 20 to to IN cord-010119-t1x9gknd 10868 21 employees employee NNS cord-010119-t1x9gknd 10868 22 in in IN cord-010119-t1x9gknd 10868 23 manufacturing manufacturing NN cord-010119-t1x9gknd 10868 24 - - HYPH cord-010119-t1x9gknd 10868 25 related relate VBN cord-010119-t1x9gknd 10868 26 jobs job NNS cord-010119-t1x9gknd 10868 27 using use VBG cord-010119-t1x9gknd 10868 28 our -PRON- PRP$ cord-010119-t1x9gknd 10868 29 learning learn VBG cord-010119-t1x9gknd 10868 30 management management NN cord-010119-t1x9gknd 10868 31 system system NN cord-010119-t1x9gknd 10868 32 . . . cord-010119-t1x9gknd 10869 1 The the DT cord-010119-t1x9gknd 10869 2 pre pre JJ cord-010119-t1x9gknd 10869 3 - - NN cord-010119-t1x9gknd 10869 4 quiz quiz NN cord-010119-t1x9gknd 10869 5 was be VBD cord-010119-t1x9gknd 10869 6 assigned assign VBN cord-010119-t1x9gknd 10869 7 to to IN cord-010119-t1x9gknd 10869 8 employees employee NNS cord-010119-t1x9gknd 10869 9 in in IN cord-010119-t1x9gknd 10869 10 June June NNP cord-010119-t1x9gknd 10869 11 2016 2016 CD cord-010119-t1x9gknd 10869 12 , , , cord-010119-t1x9gknd 10869 13 with with IN cord-010119-t1x9gknd 10869 14 a a DT cord-010119-t1x9gknd 10869 15 new new JJ cord-010119-t1x9gknd 10869 16 Equipment equipment NN cord-010119-t1x9gknd 10869 17 module module NN cord-010119-t1x9gknd 10869 18 assigned assign VBN cord-010119-t1x9gknd 10869 19 each each DT cord-010119-t1x9gknd 10869 20 month month NN cord-010119-t1x9gknd 10869 21 for for IN cord-010119-t1x9gknd 10869 22 the the DT cord-010119-t1x9gknd 10869 23 following following JJ cord-010119-t1x9gknd 10869 24 five five CD cord-010119-t1x9gknd 10869 25 months month NNS cord-010119-t1x9gknd 10869 26 . . . cord-010119-t1x9gknd 10870 1 The the DT cord-010119-t1x9gknd 10870 2 series series NN cord-010119-t1x9gknd 10870 3 concluded conclude VBD cord-010119-t1x9gknd 10870 4 in in IN cord-010119-t1x9gknd 10870 5 December December NNP cord-010119-t1x9gknd 10870 6 2016 2016 CD cord-010119-t1x9gknd 10870 7 with with IN cord-010119-t1x9gknd 10870 8 the the DT cord-010119-t1x9gknd 10870 9 post post JJ cord-010119-t1x9gknd 10870 10 - - NN cord-010119-t1x9gknd 10870 11 quiz quiz NN cord-010119-t1x9gknd 10870 12 . . . cord-010119-t1x9gknd 10871 1 Results result NNS cord-010119-t1x9gknd 10871 2 / / SYM cord-010119-t1x9gknd 10871 3 Finding finding NN cord-010119-t1x9gknd 10871 4 : : : cord-010119-t1x9gknd 10871 5 Using use VBG cord-010119-t1x9gknd 10871 6 surveys survey NNS cord-010119-t1x9gknd 10871 7 , , , cord-010119-t1x9gknd 10871 8 assessments assessment NNS cord-010119-t1x9gknd 10871 9 and and CC cord-010119-t1x9gknd 10871 10 incident incident NN cord-010119-t1x9gknd 10871 11 reports report NNS cord-010119-t1x9gknd 10871 12 , , , cord-010119-t1x9gknd 10871 13 we -PRON- PRP cord-010119-t1x9gknd 10871 14 evaluated evaluate VBD cord-010119-t1x9gknd 10871 15 the the DT cord-010119-t1x9gknd 10871 16 training training NN cord-010119-t1x9gknd 10871 17 effectiveness effectiveness NN cord-010119-t1x9gknd 10871 18 using use VBG cord-010119-t1x9gknd 10871 19 three three CD cord-010119-t1x9gknd 10871 20 of of IN cord-010119-t1x9gknd 10871 21 the the DT cord-010119-t1x9gknd 10871 22 four four CD cord-010119-t1x9gknd 10871 23 Kirkpatrick Kirkpatrick NNP cord-010119-t1x9gknd 10871 24 levels level NNS cord-010119-t1x9gknd 10871 25 . . . cord-010119-t1x9gknd 10872 1 While while IN cord-010119-t1x9gknd 10872 2 our -PRON- PRP$ cord-010119-t1x9gknd 10872 3 previous previous JJ cord-010119-t1x9gknd 10872 4 cGMP cGMP NNP cord-010119-t1x9gknd 10872 5 courses course NNS cord-010119-t1x9gknd 10872 6 received receive VBD cord-010119-t1x9gknd 10872 7 good good JJ cord-010119-t1x9gknd 10872 8 ratings rating NNS cord-010119-t1x9gknd 10872 9 from from IN cord-010119-t1x9gknd 10872 10 learners learner NNS cord-010119-t1x9gknd 10872 11 , , , cord-010119-t1x9gknd 10872 12 the the DT cord-010119-t1x9gknd 10872 13 Equipment Equipment NNP cord-010119-t1x9gknd 10872 14 series series NN cord-010119-t1x9gknd 10872 15 received receive VBD cord-010119-t1x9gknd 10872 16 the the DT cord-010119-t1x9gknd 10872 17 highest high JJS cord-010119-t1x9gknd 10872 18 rating rating NN cord-010119-t1x9gknd 10872 19 of of IN cord-010119-t1x9gknd 10872 20 3.5 3.5 CD cord-010119-t1x9gknd 10872 21 on on IN cord-010119-t1x9gknd 10872 22 a a DT cord-010119-t1x9gknd 10872 23 4-point 4-point CD cord-010119-t1x9gknd 10872 24 scale scale NN cord-010119-t1x9gknd 10872 25 . . . cord-010119-t1x9gknd 10873 1 Of of IN cord-010119-t1x9gknd 10873 2 employees employee NNS cord-010119-t1x9gknd 10873 3 who who WP cord-010119-t1x9gknd 10873 4 completed complete VBD cord-010119-t1x9gknd 10873 5 all all DT cord-010119-t1x9gknd 10873 6 versions version NNS cord-010119-t1x9gknd 10873 7 of of IN cord-010119-t1x9gknd 10873 8 our -PRON- PRP$ cord-010119-t1x9gknd 10873 9 cGMP cGMP NNP cord-010119-t1x9gknd 10873 10 courses course NNS cord-010119-t1x9gknd 10873 11 , , , cord-010119-t1x9gknd 10873 12 the the DT cord-010119-t1x9gknd 10873 13 majority majority NN cord-010119-t1x9gknd 10873 14 preferred prefer VBD cord-010119-t1x9gknd 10873 15 the the DT cord-010119-t1x9gknd 10873 16 Equipment Equipment NNP cord-010119-t1x9gknd 10873 17 series series NN cord-010119-t1x9gknd 10873 18 over over IN cord-010119-t1x9gknd 10873 19 all all DT cord-010119-t1x9gknd 10873 20 previous previous JJ cord-010119-t1x9gknd 10873 21 courses course NNS cord-010119-t1x9gknd 10873 22 combined combine VBN cord-010119-t1x9gknd 10873 23 . . . cord-010119-t1x9gknd 10874 1 Comments comment NNS cord-010119-t1x9gknd 10874 2 clearly clearly RB cord-010119-t1x9gknd 10874 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 10874 4 that that IN cord-010119-t1x9gknd 10874 5 learners learner NNS cord-010119-t1x9gknd 10874 6 preferred prefer VBD cord-010119-t1x9gknd 10874 7 the the DT cord-010119-t1x9gknd 10874 8 short short JJ cord-010119-t1x9gknd 10874 9 , , , cord-010119-t1x9gknd 10874 10 subscription subscription NN cord-010119-t1x9gknd 10874 11 format format NN cord-010119-t1x9gknd 10874 12 over over IN cord-010119-t1x9gknd 10874 13 the the DT cord-010119-t1x9gknd 10874 14 previous previous JJ cord-010119-t1x9gknd 10874 15 courses course NNS cord-010119-t1x9gknd 10874 16 with with IN cord-010119-t1x9gknd 10874 17 21 21 CD cord-010119-t1x9gknd 10874 18 positive positive JJ cord-010119-t1x9gknd 10874 19 and and CC cord-010119-t1x9gknd 10874 20 1 1 CD cord-010119-t1x9gknd 10874 21 negative negative JJ cord-010119-t1x9gknd 10874 22 comment comment NN cord-010119-t1x9gknd 10874 23 . . . cord-010119-t1x9gknd 10875 1 Level level NN cord-010119-t1x9gknd 10875 2 2 2 CD cord-010119-t1x9gknd 10875 3 : : : cord-010119-t1x9gknd 10876 1 Learning learn VBG cord-010119-t1x9gknd 10876 2 The the DT cord-010119-t1x9gknd 10876 3 average average JJ cord-010119-t1x9gknd 10876 4 score score NN cord-010119-t1x9gknd 10876 5 of of IN cord-010119-t1x9gknd 10876 6 users user NNS cord-010119-t1x9gknd 10876 7 increased increase VBD cord-010119-t1x9gknd 10876 8 13 13 CD cord-010119-t1x9gknd 10876 9 % % NN cord-010119-t1x9gknd 10876 10 from from IN cord-010119-t1x9gknd 10876 11 the the DT cord-010119-t1x9gknd 10876 12 pre pre NN cord-010119-t1x9gknd 10876 13 - - JJ cord-010119-t1x9gknd 10876 14 test test NN cord-010119-t1x9gknd 10876 15 to to IN cord-010119-t1x9gknd 10876 16 the the DT cord-010119-t1x9gknd 10876 17 posttest postt JJS cord-010119-t1x9gknd 10876 18 , , , cord-010119-t1x9gknd 10876 19 with with IN cord-010119-t1x9gknd 10876 20 the the DT cord-010119-t1x9gknd 10876 21 greatest great JJS cord-010119-t1x9gknd 10876 22 improvements improvement NNS cord-010119-t1x9gknd 10876 23 noted note VBN cord-010119-t1x9gknd 10876 24 in in IN cord-010119-t1x9gknd 10876 25 the the DT cord-010119-t1x9gknd 10876 26 scores score NNS cord-010119-t1x9gknd 10876 27 from from IN cord-010119-t1x9gknd 10876 28 laboratory laboratory NN cord-010119-t1x9gknd 10876 29 employees employee NNS cord-010119-t1x9gknd 10876 30 . . . cord-010119-t1x9gknd 10877 1 A a DT cord-010119-t1x9gknd 10877 2 two two CD cord-010119-t1x9gknd 10877 3 - - HYPH cord-010119-t1x9gknd 10877 4 sample sample NN cord-010119-t1x9gknd 10877 5 t t NN cord-010119-t1x9gknd 10877 6 - - HYPH cord-010119-t1x9gknd 10877 7 Test Test NNP cord-010119-t1x9gknd 10877 8 determined determine VBD cord-010119-t1x9gknd 10877 9 the the DT cord-010119-t1x9gknd 10877 10 result result NN cord-010119-t1x9gknd 10877 11 to to TO cord-010119-t1x9gknd 10877 12 be be VB cord-010119-t1x9gknd 10877 13 statistically statistically RB cord-010119-t1x9gknd 10877 14 significant significant JJ cord-010119-t1x9gknd 10877 15 with with IN cord-010119-t1x9gknd 10877 16 a a DT cord-010119-t1x9gknd 10877 17 t t NN cord-010119-t1x9gknd 10877 18 - - HYPH cord-010119-t1x9gknd 10877 19 Critical critical JJ cord-010119-t1x9gknd 10877 20 value value NN cord-010119-t1x9gknd 10877 21 of of IN cord-010119-t1x9gknd 10877 22 1.647 1.647 CD cord-010119-t1x9gknd 10877 23 and and CC cord-010119-t1x9gknd 10877 24 a a DT cord-010119-t1x9gknd 10877 25 t t NN cord-010119-t1x9gknd 10877 26 - - HYPH cord-010119-t1x9gknd 10877 27 Stat stat JJ cord-010119-t1x9gknd 10877 28 value value NN cord-010119-t1x9gknd 10877 29 of of IN cord-010119-t1x9gknd 10877 30 5.641 5.641 CD cord-010119-t1x9gknd 10877 31 . . . cord-010119-t1x9gknd 10878 1 Level level NN cord-010119-t1x9gknd 10878 2 4 4 CD cord-010119-t1x9gknd 10878 3 : : : cord-010119-t1x9gknd 10878 4 Results result NNS cord-010119-t1x9gknd 10879 1 While while IN cord-010119-t1x9gknd 10879 2 equipment equipment NN cord-010119-t1x9gknd 10879 3 - - HYPH cord-010119-t1x9gknd 10879 4 related relate VBN cord-010119-t1x9gknd 10879 5 errors error NNS cord-010119-t1x9gknd 10879 6 decreased decrease VBD cord-010119-t1x9gknd 10879 7 by by IN cord-010119-t1x9gknd 10879 8 20 20 CD cord-010119-t1x9gknd 10879 9 % % NN cord-010119-t1x9gknd 10879 10 after after IN cord-010119-t1x9gknd 10879 11 training training NN cord-010119-t1x9gknd 10879 12 , , , cord-010119-t1x9gknd 10879 13 there there EX cord-010119-t1x9gknd 10879 14 is be VBZ cord-010119-t1x9gknd 10879 15 not not RB cord-010119-t1x9gknd 10879 16 enough enough JJ cord-010119-t1x9gknd 10879 17 data datum NNS cord-010119-t1x9gknd 10879 18 to to TO cord-010119-t1x9gknd 10879 19 demonstrate demonstrate VB cord-010119-t1x9gknd 10879 20 a a DT cord-010119-t1x9gknd 10879 21 statistical statistical JJ cord-010119-t1x9gknd 10879 22 significance significance NN cord-010119-t1x9gknd 10879 23 . . . cord-010119-t1x9gknd 10880 1 Conclusion conclusion NN cord-010119-t1x9gknd 10880 2 : : : cord-010119-t1x9gknd 10881 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10881 2 Level level NN cord-010119-t1x9gknd 10881 3 1 1 CD cord-010119-t1x9gknd 10881 4 and and CC cord-010119-t1x9gknd 10881 5 2 2 CD cord-010119-t1x9gknd 10881 6 evaluation evaluation NN cord-010119-t1x9gknd 10881 7 data datum NNS cord-010119-t1x9gknd 10881 8 validated validate VBD cord-010119-t1x9gknd 10881 9 that that IN cord-010119-t1x9gknd 10881 10 the the DT cord-010119-t1x9gknd 10881 11 subscription subscription NN cord-010119-t1x9gknd 10881 12 approach approach NN cord-010119-t1x9gknd 10881 13 was be VBD cord-010119-t1x9gknd 10881 14 effective effective JJ cord-010119-t1x9gknd 10881 15 . . . cord-010119-t1x9gknd 10882 1 Knowledge knowledge NN cord-010119-t1x9gknd 10882 2 increased increase VBD cord-010119-t1x9gknd 10882 3 from from IN cord-010119-t1x9gknd 10882 4 the the DT cord-010119-t1x9gknd 10882 5 pre pre NN cord-010119-t1x9gknd 10882 6 - - NN cord-010119-t1x9gknd 10882 7 to to IN cord-010119-t1x9gknd 10882 8 postquiz postquiz NNP cord-010119-t1x9gknd 10882 9 , , , cord-010119-t1x9gknd 10882 10 learners learner NNS cord-010119-t1x9gknd 10882 11 reported report VBD cord-010119-t1x9gknd 10882 12 that that IN cord-010119-t1x9gknd 10882 13 they -PRON- PRP cord-010119-t1x9gknd 10882 14 appreciated appreciate VBD cord-010119-t1x9gknd 10882 15 the the DT cord-010119-t1x9gknd 10882 16 shorter short JJR cord-010119-t1x9gknd 10882 17 training training NN cord-010119-t1x9gknd 10882 18 , , , cord-010119-t1x9gknd 10882 19 and and CC cord-010119-t1x9gknd 10882 20 they -PRON- PRP cord-010119-t1x9gknd 10882 21 completed complete VBD cord-010119-t1x9gknd 10882 22 the the DT cord-010119-t1x9gknd 10882 23 modules module NNS cord-010119-t1x9gknd 10882 24 without without IN cord-010119-t1x9gknd 10882 25 special special JJ cord-010119-t1x9gknd 10882 26 scheduling scheduling NN cord-010119-t1x9gknd 10882 27 requirements requirement NNS cord-010119-t1x9gknd 10882 28 . . . cord-010119-t1x9gknd 10883 1 As as IN cord-010119-t1x9gknd 10883 2 a a DT cord-010119-t1x9gknd 10883 3 result result NN cord-010119-t1x9gknd 10883 4 , , , cord-010119-t1x9gknd 10883 5 we -PRON- PRP cord-010119-t1x9gknd 10883 6 are be VBP cord-010119-t1x9gknd 10883 7 continuing continue VBG cord-010119-t1x9gknd 10883 8 development development NN cord-010119-t1x9gknd 10883 9 of of IN cord-010119-t1x9gknd 10883 10 the the DT cord-010119-t1x9gknd 10883 11 remaining remain VBG cord-010119-t1x9gknd 10883 12 series series NN cord-010119-t1x9gknd 10883 13 . . . cord-010119-t1x9gknd 10884 1 Background Background NNP cord-010119-t1x9gknd 10884 2 / / SYM cord-010119-t1x9gknd 10884 3 Case Case NNP cord-010119-t1x9gknd 10884 4 Studies Studies NNPS cord-010119-t1x9gknd 10884 5 : : : cord-010119-t1x9gknd 10885 1 The the DT cord-010119-t1x9gknd 10885 2 interdisciplinary interdisciplinary JJ cord-010119-t1x9gknd 10885 3 nature nature NN cord-010119-t1x9gknd 10885 4 of of IN cord-010119-t1x9gknd 10885 5 transfusion transfusion NN cord-010119-t1x9gknd 10885 6 medicine medicine NN cord-010119-t1x9gknd 10885 7 requires require VBZ cord-010119-t1x9gknd 10885 8 the the DT cord-010119-t1x9gknd 10885 9 collaboration collaboration NN cord-010119-t1x9gknd 10885 10 of of IN cord-010119-t1x9gknd 10885 11 multiple multiple JJ cord-010119-t1x9gknd 10885 12 work work NN cord-010119-t1x9gknd 10885 13 units unit NNS cord-010119-t1x9gknd 10885 14 for for IN cord-010119-t1x9gknd 10885 15 efficient efficient JJ cord-010119-t1x9gknd 10885 16 patient patient NN cord-010119-t1x9gknd 10885 17 care care NN cord-010119-t1x9gknd 10885 18 , , , cord-010119-t1x9gknd 10885 19 but but CC cord-010119-t1x9gknd 10885 20 departmental departmental JJ cord-010119-t1x9gknd 10885 21 " " `` cord-010119-t1x9gknd 10885 22 silos silo NNS cord-010119-t1x9gknd 10885 23 " " '' cord-010119-t1x9gknd 10885 24 impede impede VB cord-010119-t1x9gknd 10885 25 collaboration collaboration NN cord-010119-t1x9gknd 10885 26 between between IN cord-010119-t1x9gknd 10885 27 transfusionrelated transfusionrelated JJ cord-010119-t1x9gknd 10885 28 care care NN cord-010119-t1x9gknd 10885 29 teams team NNS cord-010119-t1x9gknd 10885 30 . . . cord-010119-t1x9gknd 10886 1 We -PRON- PRP cord-010119-t1x9gknd 10886 2 hypothesized hypothesize VBD cord-010119-t1x9gknd 10886 3 that that IN cord-010119-t1x9gknd 10886 4 regular regular JJ cord-010119-t1x9gknd 10886 5 educational educational JJ cord-010119-t1x9gknd 10886 6 meetings meeting NNS cord-010119-t1x9gknd 10886 7 would would MD cord-010119-t1x9gknd 10886 8 improve improve VB cord-010119-t1x9gknd 10886 9 knowledge knowledge NN cord-010119-t1x9gknd 10886 10 and and CC cord-010119-t1x9gknd 10886 11 awareness awareness NN cord-010119-t1x9gknd 10886 12 of of IN cord-010119-t1x9gknd 10886 13 each each DT cord-010119-t1x9gknd 10886 14 department department NN cord-010119-t1x9gknd 10886 15 's 's POS cord-010119-t1x9gknd 10886 16 role role NN cord-010119-t1x9gknd 10886 17 , , , cord-010119-t1x9gknd 10886 18 so so RB cord-010119-t1x9gknd 10886 19 in in IN cord-010119-t1x9gknd 10886 20 October October NNP cord-010119-t1x9gknd 10886 21 2013 2013 CD cord-010119-t1x9gknd 10886 22 , , , cord-010119-t1x9gknd 10886 23 a a DT cord-010119-t1x9gknd 10886 24 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 10886 25 educational educational JJ cord-010119-t1x9gknd 10886 26 meeting meeting NN cord-010119-t1x9gknd 10886 27 called call VBN cord-010119-t1x9gknd 10886 28 Friday Friday NNP cord-010119-t1x9gknd 10886 29 Blood Blood NNP cord-010119-t1x9gknd 10886 30 Conference Conference NNP cord-010119-t1x9gknd 10886 31 ( ( -LRB- cord-010119-t1x9gknd 10886 32 FBC FBC NNP cord-010119-t1x9gknd 10886 33 ) ) -RRB- cord-010119-t1x9gknd 10886 34 began begin VBD cord-010119-t1x9gknd 10886 35 as as IN cord-010119-t1x9gknd 10886 36 a a DT cord-010119-t1x9gknd 10886 37 collaborative collaborative NN cord-010119-t1x9gknd 10886 38 , , , cord-010119-t1x9gknd 10886 39 interprofessional interprofessional NNP cord-010119-t1x9gknd 10886 40 forum forum NNP cord-010119-t1x9gknd 10886 41 involving involve VBG cord-010119-t1x9gknd 10886 42 frontline frontline JJ cord-010119-t1x9gknd 10886 43 staff staff NN cord-010119-t1x9gknd 10886 44 of of IN cord-010119-t1x9gknd 10886 45 our -PRON- PRP$ cord-010119-t1x9gknd 10886 46 transfusion transfusion NN cord-010119-t1x9gknd 10886 47 practice practice NN cord-010119-t1x9gknd 10886 48 . . . cord-010119-t1x9gknd 10887 1 During during IN cord-010119-t1x9gknd 10887 2 these these DT cord-010119-t1x9gknd 10887 3 monthly monthly JJ cord-010119-t1x9gknd 10887 4 meetings meeting NNS cord-010119-t1x9gknd 10887 5 , , , cord-010119-t1x9gknd 10887 6 which which WDT cord-010119-t1x9gknd 10887 7 are be VBP cord-010119-t1x9gknd 10887 8 also also RB cord-010119-t1x9gknd 10887 9 broadcast broadcast VBN cord-010119-t1x9gknd 10887 10 online online RB cord-010119-t1x9gknd 10887 11 for for IN cord-010119-t1x9gknd 10887 12 those those DT cord-010119-t1x9gknd 10887 13 unable unable JJ cord-010119-t1x9gknd 10887 14 to to TO cord-010119-t1x9gknd 10887 15 attend attend VB cord-010119-t1x9gknd 10887 16 in in IN cord-010119-t1x9gknd 10887 17 person person NN cord-010119-t1x9gknd 10887 18 , , , cord-010119-t1x9gknd 10887 19 presenters presenter NNS cord-010119-t1x9gknd 10887 20 from from IN cord-010119-t1x9gknd 10887 21 different different JJ cord-010119-t1x9gknd 10887 22 work work NN cord-010119-t1x9gknd 10887 23 units unit NNS cord-010119-t1x9gknd 10887 24 share share VBP cord-010119-t1x9gknd 10887 25 background background NN cord-010119-t1x9gknd 10887 26 information information NN cord-010119-t1x9gknd 10887 27 and and CC cord-010119-t1x9gknd 10887 28 patient patient JJ cord-010119-t1x9gknd 10887 29 cases case NNS cord-010119-t1x9gknd 10887 30 before before IN cord-010119-t1x9gknd 10887 31 opening open VBG cord-010119-t1x9gknd 10887 32 the the DT cord-010119-t1x9gknd 10887 33 floor floor NN cord-010119-t1x9gknd 10887 34 to to IN cord-010119-t1x9gknd 10887 35 constructive constructive JJ cord-010119-t1x9gknd 10887 36 discussion discussion NN cord-010119-t1x9gknd 10887 37 . . . cord-010119-t1x9gknd 10888 1 Study Study NNP cord-010119-t1x9gknd 10888 2 Design Design NNP cord-010119-t1x9gknd 10888 3 / / SYM cord-010119-t1x9gknd 10888 4 Method method NN cord-010119-t1x9gknd 10888 5 : : : cord-010119-t1x9gknd 10889 1 A a DT cord-010119-t1x9gknd 10889 2 survey survey NN cord-010119-t1x9gknd 10889 3 was be VBD cord-010119-t1x9gknd 10889 4 sent send VBN cord-010119-t1x9gknd 10889 5 to to IN cord-010119-t1x9gknd 10889 6 FBC FBC NNP cord-010119-t1x9gknd 10889 7 participants participant NNS cord-010119-t1x9gknd 10889 8 ( ( -LRB- cord-010119-t1x9gknd 10889 9 n5151 n5151 NNP cord-010119-t1x9gknd 10889 10 ) ) -RRB- cord-010119-t1x9gknd 10889 11 to to TO cord-010119-t1x9gknd 10889 12 retrospectively retrospectively RB cord-010119-t1x9gknd 10889 13 capture capture VB cord-010119-t1x9gknd 10889 14 the the DT cord-010119-t1x9gknd 10889 15 effect effect NN cord-010119-t1x9gknd 10889 16 of of IN cord-010119-t1x9gknd 10889 17 FBC FBC NNP cord-010119-t1x9gknd 10889 18 on on IN cord-010119-t1x9gknd 10889 19 interdepartmental interdepartmental JJ cord-010119-t1x9gknd 10889 20 collaboration collaboration NN cord-010119-t1x9gknd 10889 21 . . . cord-010119-t1x9gknd 10890 1 The the DT cord-010119-t1x9gknd 10890 2 survey survey NN cord-010119-t1x9gknd 10890 3 was be VBD cord-010119-t1x9gknd 10890 4 structured structure VBN cord-010119-t1x9gknd 10890 5 to to TO cord-010119-t1x9gknd 10890 6 obtain obtain VB cord-010119-t1x9gknd 10890 7 formative formative JJ cord-010119-t1x9gknd 10890 8 feedback feedback NN cord-010119-t1x9gknd 10890 9 using use VBG cord-010119-t1x9gknd 10890 10 the the DT cord-010119-t1x9gknd 10890 11 published publish VBN cord-010119-t1x9gknd 10890 12 Interprofessional Interprofessional NNP cord-010119-t1x9gknd 10890 13 Collaborative Collaborative NNP cord-010119-t1x9gknd 10890 14 Practice Practice NNP cord-010119-t1x9gknd 10890 15 Competencies Competencies NNPS cord-010119-t1x9gknd 10890 16 ( ( -LRB- cord-010119-t1x9gknd 10890 17 ICPC ICPC NNP cord-010119-t1x9gknd 10890 18 ) ) -RRB- cord-010119-t1x9gknd 10890 19 as as IN cord-010119-t1x9gknd 10890 20 a a DT cord-010119-t1x9gknd 10890 21 guide guide NN cord-010119-t1x9gknd 10890 22 . . . cord-010119-t1x9gknd 10891 1 These these DT cord-010119-t1x9gknd 10891 2 core core NN cord-010119-t1x9gknd 10891 3 competencies competency NNS cord-010119-t1x9gknd 10891 4 target target VBP cord-010119-t1x9gknd 10891 5 maintaining maintain VBG cord-010119-t1x9gknd 10891 6 a a DT cord-010119-t1x9gknd 10891 7 climate climate NN cord-010119-t1x9gknd 10891 8 of of IN cord-010119-t1x9gknd 10891 9 mutual mutual JJ cord-010119-t1x9gknd 10891 10 respect respect NN cord-010119-t1x9gknd 10891 11 , , , cord-010119-t1x9gknd 10891 12 communicating communicate VBG cord-010119-t1x9gknd 10891 13 within within IN cord-010119-t1x9gknd 10891 14 and and CC cord-010119-t1x9gknd 10891 15 between between IN cord-010119-t1x9gknd 10891 16 departments department NNS cord-010119-t1x9gknd 10891 17 , , , cord-010119-t1x9gknd 10891 18 fostering foster VBG cord-010119-t1x9gknd 10891 19 teamwork teamwork NN cord-010119-t1x9gknd 10891 20 , , , cord-010119-t1x9gknd 10891 21 and and CC cord-010119-t1x9gknd 10891 22 understanding understand VBG cord-010119-t1x9gknd 10891 23 everyone everyone NN cord-010119-t1x9gknd 10891 24 's 's POS cord-010119-t1x9gknd 10891 25 role role NN cord-010119-t1x9gknd 10891 26 in in IN cord-010119-t1x9gknd 10891 27 patient patient JJ cord-010119-t1x9gknd 10891 28 care care NN cord-010119-t1x9gknd 10891 29 . . . cord-010119-t1x9gknd 10892 1 Results result NNS cord-010119-t1x9gknd 10893 1 /Finding /finde VBG cord-010119-t1x9gknd 10893 2 : : : cord-010119-t1x9gknd 10894 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10894 2 survey survey NN cord-010119-t1x9gknd 10894 3 response response NN cord-010119-t1x9gknd 10894 4 rate rate NN cord-010119-t1x9gknd 10894 5 was be VBD cord-010119-t1x9gknd 10894 6 35 35 CD cord-010119-t1x9gknd 10894 7 % % NN cord-010119-t1x9gknd 10894 8 . . . cord-010119-t1x9gknd 10895 1 Of of IN cord-010119-t1x9gknd 10895 2 those those DT cord-010119-t1x9gknd 10895 3 , , , cord-010119-t1x9gknd 10895 4 96 96 CD cord-010119-t1x9gknd 10895 5 % % NN cord-010119-t1x9gknd 10895 6 endorse endorse NN cord-010119-t1x9gknd 10895 7 that that IN cord-010119-t1x9gknd 10895 8 FBC FBC NNP cord-010119-t1x9gknd 10895 9 creates create VBZ cord-010119-t1x9gknd 10895 10 a a DT cord-010119-t1x9gknd 10895 11 climate climate NN cord-010119-t1x9gknd 10895 12 of of IN cord-010119-t1x9gknd 10895 13 respect respect NN cord-010119-t1x9gknd 10895 14 within within IN cord-010119-t1x9gknd 10895 15 our -PRON- PRP$ cord-010119-t1x9gknd 10895 16 transfusion transfusion NN cord-010119-t1x9gknd 10895 17 practice practice NN cord-010119-t1x9gknd 10895 18 , , , cord-010119-t1x9gknd 10895 19 94 94 CD cord-010119-t1x9gknd 10895 20 % % NN cord-010119-t1x9gknd 10895 21 believe believe VBP cord-010119-t1x9gknd 10895 22 it -PRON- PRP cord-010119-t1x9gknd 10895 23 has have VBZ cord-010119-t1x9gknd 10895 24 improved improve VBN cord-010119-t1x9gknd 10895 25 communication communication NN cord-010119-t1x9gknd 10895 26 between between IN cord-010119-t1x9gknd 10895 27 work work NN cord-010119-t1x9gknd 10895 28 units unit NNS cord-010119-t1x9gknd 10895 29 , , , cord-010119-t1x9gknd 10895 30 and and CC cord-010119-t1x9gknd 10895 31 98 98 CD cord-010119-t1x9gknd 10895 32 % % NN cord-010119-t1x9gknd 10895 33 feel feel VBP cord-010119-t1x9gknd 10895 34 that that IN cord-010119-t1x9gknd 10895 35 FBC FBC NNP cord-010119-t1x9gknd 10895 36 leads lead VBZ cord-010119-t1x9gknd 10895 37 to to IN cord-010119-t1x9gknd 10895 38 increased increase VBN cord-010119-t1x9gknd 10895 39 understanding understanding NN cord-010119-t1x9gknd 10895 40 of of IN cord-010119-t1x9gknd 10895 41 interdepartmental interdepartmental JJ cord-010119-t1x9gknd 10895 42 processes process NNS cord-010119-t1x9gknd 10895 43 . . . cord-010119-t1x9gknd 10896 1 Notably notably RB cord-010119-t1x9gknd 10896 2 , , , cord-010119-t1x9gknd 10896 3 laboratory laboratory NN cord-010119-t1x9gknd 10896 4 scientists scientist NNS cord-010119-t1x9gknd 10896 5 and and CC cord-010119-t1x9gknd 10896 6 transfusion transfusion NN cord-010119-t1x9gknd 10896 7 nurses nurse NNS cord-010119-t1x9gknd 10896 8 have have VBP cord-010119-t1x9gknd 10896 9 the the DT cord-010119-t1x9gknd 10896 10 highest high JJS cord-010119-t1x9gknd 10896 11 attendance attendance NN cord-010119-t1x9gknd 10896 12 rate rate NN cord-010119-t1x9gknd 10896 13 . . . cord-010119-t1x9gknd 10897 1 Furthermore furthermore RB cord-010119-t1x9gknd 10897 2 , , , cord-010119-t1x9gknd 10897 3 those those DT cord-010119-t1x9gknd 10897 4 attending attend VBG cord-010119-t1x9gknd 10897 5 via via IN cord-010119-t1x9gknd 10897 6 the the DT cord-010119-t1x9gknd 10897 7 online online JJ cord-010119-t1x9gknd 10897 8 broadcast broadcast NN cord-010119-t1x9gknd 10897 9 report report NN cord-010119-t1x9gknd 10897 10 the the DT cord-010119-t1x9gknd 10897 11 lowest low JJS cord-010119-t1x9gknd 10897 12 satisfaction satisfaction NN cord-010119-t1x9gknd 10897 13 , , , cord-010119-t1x9gknd 10897 14 with with IN cord-010119-t1x9gknd 10897 15 only only RB cord-010119-t1x9gknd 10897 16 56 56 CD cord-010119-t1x9gknd 10897 17 % % NN cord-010119-t1x9gknd 10897 18 responding respond VBG cord-010119-t1x9gknd 10897 19 positively positively RB cord-010119-t1x9gknd 10897 20 . . . cord-010119-t1x9gknd 10898 1 The the DT cord-010119-t1x9gknd 10898 2 main main JJ cord-010119-t1x9gknd 10898 3 reasons reason NNS cord-010119-t1x9gknd 10898 4 individuals individual NNS cord-010119-t1x9gknd 10898 5 attend attend VBP cord-010119-t1x9gknd 10898 6 FBC FBC NNP cord-010119-t1x9gknd 10898 7 are be VBP cord-010119-t1x9gknd 10898 8 to to TO cord-010119-t1x9gknd 10898 9 increase increase VB cord-010119-t1x9gknd 10898 10 knowledge knowledge NN cord-010119-t1x9gknd 10898 11 about about IN cord-010119-t1x9gknd 10898 12 transfusion transfusion NN cord-010119-t1x9gknd 10898 13 medicine medicine NN cord-010119-t1x9gknd 10898 14 , , , cord-010119-t1x9gknd 10898 15 interact interact VB cord-010119-t1x9gknd 10898 16 with with IN cord-010119-t1x9gknd 10898 17 and and CC cord-010119-t1x9gknd 10898 18 learn learn VB cord-010119-t1x9gknd 10898 19 from from IN cord-010119-t1x9gknd 10898 20 other other JJ cord-010119-t1x9gknd 10898 21 departments department NNS cord-010119-t1x9gknd 10898 22 , , , cord-010119-t1x9gknd 10898 23 hear hear VB cord-010119-t1x9gknd 10898 24 about about IN cord-010119-t1x9gknd 10898 25 patient patient JJ cord-010119-t1x9gknd 10898 26 case case NN cord-010119-t1x9gknd 10898 27 studies study NNS cord-010119-t1x9gknd 10898 28 , , , cord-010119-t1x9gknd 10898 29 and and CC cord-010119-t1x9gknd 10898 30 understand understand VB cord-010119-t1x9gknd 10898 31 the the DT cord-010119-t1x9gknd 10898 32 " " `` cord-010119-t1x9gknd 10898 33 big big JJ cord-010119-t1x9gknd 10898 34 picture picture NN cord-010119-t1x9gknd 10898 35 " " '' cord-010119-t1x9gknd 10898 36 of of IN cord-010119-t1x9gknd 10898 37 one one PRP cord-010119-t1x9gknd 10898 38 's 's POS cord-010119-t1x9gknd 10898 39 role role NN cord-010119-t1x9gknd 10898 40 in in IN cord-010119-t1x9gknd 10898 41 patient patient JJ cord-010119-t1x9gknd 10898 42 care care NN cord-010119-t1x9gknd 10898 43 . . . cord-010119-t1x9gknd 10899 1 Suggestions suggestion NNS cord-010119-t1x9gknd 10899 2 for for IN cord-010119-t1x9gknd 10899 3 improvement improvement NN cord-010119-t1x9gknd 10899 4 include include VBP cord-010119-t1x9gknd 10899 5 preparing prepare VBG cord-010119-t1x9gknd 10899 6 questions question NNS cord-010119-t1x9gknd 10899 7 to to TO cord-010119-t1x9gknd 10899 8 help help VB cord-010119-t1x9gknd 10899 9 initiate initiate VB cord-010119-t1x9gknd 10899 10 discussion discussion NN cord-010119-t1x9gknd 10899 11 , , , cord-010119-t1x9gknd 10899 12 increasing increase VBG cord-010119-t1x9gknd 10899 13 representation representation NN cord-010119-t1x9gknd 10899 14 of of IN cord-010119-t1x9gknd 10899 15 other other JJ cord-010119-t1x9gknd 10899 16 areas area NNS cord-010119-t1x9gknd 10899 17 for for IN cord-010119-t1x9gknd 10899 18 broader broad JJR cord-010119-t1x9gknd 10899 19 perspectives perspective NNS cord-010119-t1x9gknd 10899 20 during during IN cord-010119-t1x9gknd 10899 21 interdepartmental interdepartmental JJ cord-010119-t1x9gknd 10899 22 dialogue dialogue NN cord-010119-t1x9gknd 10899 23 , , , cord-010119-t1x9gknd 10899 24 and and CC cord-010119-t1x9gknd 10899 25 posting post VBG cord-010119-t1x9gknd 10899 26 recordings recording NNS cord-010119-t1x9gknd 10899 27 of of IN cord-010119-t1x9gknd 10899 28 FBC FBC NNP cord-010119-t1x9gknd 10899 29 for for IN cord-010119-t1x9gknd 10899 30 later later RB cord-010119-t1x9gknd 10899 31 viewing view VBG cord-010119-t1x9gknd 10899 32 . . . cord-010119-t1x9gknd 10900 1 Conclusion conclusion NN cord-010119-t1x9gknd 10900 2 : : : cord-010119-t1x9gknd 10900 3 The the DT cord-010119-t1x9gknd 10900 4 application application NN cord-010119-t1x9gknd 10900 5 of of IN cord-010119-t1x9gknd 10900 6 ICPC ICPC NNP cord-010119-t1x9gknd 10900 7 in in IN cord-010119-t1x9gknd 10900 8 transfusion transfusion NN cord-010119-t1x9gknd 10900 9 medicine medicine NN cord-010119-t1x9gknd 10900 10 was be VBD cord-010119-t1x9gknd 10900 11 an an DT cord-010119-t1x9gknd 10900 12 effective effective JJ cord-010119-t1x9gknd 10900 13 lens lens NN cord-010119-t1x9gknd 10900 14 to to TO cord-010119-t1x9gknd 10900 15 assess assess VB cord-010119-t1x9gknd 10900 16 the the DT cord-010119-t1x9gknd 10900 17 value value NN cord-010119-t1x9gknd 10900 18 of of IN cord-010119-t1x9gknd 10900 19 interprofessional interprofessional JJ cord-010119-t1x9gknd 10900 20 collaboration collaboration NN cord-010119-t1x9gknd 10900 21 . . . cord-010119-t1x9gknd 10901 1 Although although IN cord-010119-t1x9gknd 10901 2 there there EX cord-010119-t1x9gknd 10901 3 is be VBZ cord-010119-t1x9gknd 10901 4 room room NN cord-010119-t1x9gknd 10901 5 for for IN cord-010119-t1x9gknd 10901 6 improvement improvement NN cord-010119-t1x9gknd 10901 7 , , , cord-010119-t1x9gknd 10901 8 the the DT cord-010119-t1x9gknd 10901 9 results result NNS cord-010119-t1x9gknd 10901 10 support support NN cord-010119-t1x9gknd 10901 11 that that IN cord-010119-t1x9gknd 10901 12 FBC FBC NNP cord-010119-t1x9gknd 10901 13 has have VBZ cord-010119-t1x9gknd 10901 14 contributed contribute VBN cord-010119-t1x9gknd 10901 15 to to IN cord-010119-t1x9gknd 10901 16 better well JJR cord-010119-t1x9gknd 10901 17 communication communication NN cord-010119-t1x9gknd 10901 18 between between IN cord-010119-t1x9gknd 10901 19 transfusion transfusion NN cord-010119-t1x9gknd 10901 20 - - HYPH cord-010119-t1x9gknd 10901 21 related relate VBN cord-010119-t1x9gknd 10901 22 care care NN cord-010119-t1x9gknd 10901 23 teams team NNS cord-010119-t1x9gknd 10901 24 and and CC cord-010119-t1x9gknd 10901 25 has have VBZ cord-010119-t1x9gknd 10901 26 increased increase VBN cord-010119-t1x9gknd 10901 27 understanding understanding NN cord-010119-t1x9gknd 10901 28 of of IN cord-010119-t1x9gknd 10901 29 interdepartmental interdepartmental JJ cord-010119-t1x9gknd 10901 30 processes process NNS cord-010119-t1x9gknd 10901 31 within within IN cord-010119-t1x9gknd 10901 32 our -PRON- PRP$ cord-010119-t1x9gknd 10901 33 transfusion transfusion NN cord-010119-t1x9gknd 10901 34 practice practice NN cord-010119-t1x9gknd 10901 35 . . . cord-010119-t1x9gknd 10902 1 Novel Novel NNP cord-010119-t1x9gknd 10902 2 Approach Approach NNP cord-010119-t1x9gknd 10902 3 to to IN cord-010119-t1x9gknd 10902 4 Curriculum Curriculum NNP cord-010119-t1x9gknd 10902 5 Development Development NNP cord-010119-t1x9gknd 10902 6 : : : cord-010119-t1x9gknd 10903 1 Demystifying demystify VBG cord-010119-t1x9gknd 10903 2 Transfusion Transfusion NNP cord-010119-t1x9gknd 10903 3 Medicine Medicine NNP cord-010119-t1x9gknd 10903 4 Ritcha Ritcha NNP cord-010119-t1x9gknd 10903 5 Saxena Saxena NNP cord-010119-t1x9gknd 10903 6 * * NFP cord-010119-t1x9gknd 10903 7 and and CC cord-010119-t1x9gknd 10903 8 Ananya Ananya NNP cord-010119-t1x9gknd 10903 9 Saxena Saxena NNP cord-010119-t1x9gknd 10903 10 . . . cord-010119-t1x9gknd 10904 1 All all DT cord-010119-t1x9gknd 10904 2 Saints Saints NNPS cord-010119-t1x9gknd 10904 3 University University NNP cord-010119-t1x9gknd 10904 4 School School NNP cord-010119-t1x9gknd 10904 5 of of IN cord-010119-t1x9gknd 10904 6 Medicine Medicine NNP cord-010119-t1x9gknd 10904 7 Background Background NNP cord-010119-t1x9gknd 10904 8 / / SYM cord-010119-t1x9gknd 10904 9 Case Case NNP cord-010119-t1x9gknd 10904 10 Studies Studies NNPS cord-010119-t1x9gknd 10905 1 : : : cord-010119-t1x9gknd 10905 2 Transfusion transfusion NN cord-010119-t1x9gknd 10905 3 medicine medicine NN cord-010119-t1x9gknd 10905 4 is be VBZ cord-010119-t1x9gknd 10905 5 an an DT cord-010119-t1x9gknd 10905 6 essential essential JJ cord-010119-t1x9gknd 10905 7 element element NN cord-010119-t1x9gknd 10905 8 of of IN cord-010119-t1x9gknd 10905 9 education education NN cord-010119-t1x9gknd 10905 10 required require VBN cord-010119-t1x9gknd 10905 11 for for IN cord-010119-t1x9gknd 10905 12 the the DT cord-010119-t1x9gknd 10905 13 future future JJ cord-010119-t1x9gknd 10905 14 physicians physician NNS cord-010119-t1x9gknd 10905 15 in in IN cord-010119-t1x9gknd 10905 16 various various JJ cord-010119-t1x9gknd 10905 17 disciplines discipline NNS cord-010119-t1x9gknd 10905 18 like like IN cord-010119-t1x9gknd 10905 19 surgery surgery NN cord-010119-t1x9gknd 10905 20 , , , cord-010119-t1x9gknd 10905 21 internal internal JJ cord-010119-t1x9gknd 10905 22 medicine medicine NN cord-010119-t1x9gknd 10905 23 and and CC cord-010119-t1x9gknd 10905 24 anesthesiologists anesthesiologist NNS cord-010119-t1x9gknd 10905 25 to to TO cord-010119-t1x9gknd 10905 26 work work VB cord-010119-t1x9gknd 10905 27 effectively effectively RB cord-010119-t1x9gknd 10905 28 with with IN cord-010119-t1x9gknd 10905 29 the the DT cord-010119-t1x9gknd 10905 30 blood blood NN cord-010119-t1x9gknd 10905 31 bank bank NN cord-010119-t1x9gknd 10905 32 personnel personnel NNS cord-010119-t1x9gknd 10905 33 . . . cord-010119-t1x9gknd 10906 1 Transfusion transfusion NN cord-010119-t1x9gknd 10906 2 carries carry VBZ cord-010119-t1x9gknd 10906 3 considerable considerable JJ cord-010119-t1x9gknd 10906 4 advantages advantage NNS cord-010119-t1x9gknd 10906 5 as as RB cord-010119-t1x9gknd 10906 6 well well RB cord-010119-t1x9gknd 10906 7 as as IN cord-010119-t1x9gknd 10906 8 risks risk NNS cord-010119-t1x9gknd 10906 9 . . . cord-010119-t1x9gknd 10907 1 Consequently consequently RB cord-010119-t1x9gknd 10907 2 , , , cord-010119-t1x9gknd 10907 3 educational educational JJ cord-010119-t1x9gknd 10907 4 initiatives initiative NNS cord-010119-t1x9gknd 10907 5 are be VBP cord-010119-t1x9gknd 10907 6 required require VBN cord-010119-t1x9gknd 10907 7 to to TO cord-010119-t1x9gknd 10907 8 identify identify VB cord-010119-t1x9gknd 10907 9 the the DT cord-010119-t1x9gknd 10907 10 particular particular JJ cord-010119-t1x9gknd 10907 11 knowledge knowledge NN cord-010119-t1x9gknd 10907 12 deficits deficit NNS cord-010119-t1x9gknd 10907 13 in in IN cord-010119-t1x9gknd 10907 14 transfusion transfusion NN cord-010119-t1x9gknd 10907 15 medicine medicine NN cord-010119-t1x9gknd 10907 16 and and CC cord-010119-t1x9gknd 10907 17 subsequently subsequently RB cord-010119-t1x9gknd 10907 18 , , , cord-010119-t1x9gknd 10907 19 bridge bridge VB cord-010119-t1x9gknd 10907 20 the the DT cord-010119-t1x9gknd 10907 21 gaps gap NNS cord-010119-t1x9gknd 10907 22 . . . cord-010119-t1x9gknd 10908 1 And and CC cord-010119-t1x9gknd 10908 2 the the DT cord-010119-t1x9gknd 10908 3 challenge challenge NN cord-010119-t1x9gknd 10908 4 is be VBZ cord-010119-t1x9gknd 10908 5 to to TO cord-010119-t1x9gknd 10908 6 update update VB cord-010119-t1x9gknd 10908 7 the the DT cord-010119-t1x9gknd 10908 8 undergraduate undergraduate JJ cord-010119-t1x9gknd 10908 9 medical medical JJ cord-010119-t1x9gknd 10908 10 curriculum curriculum NN cord-010119-t1x9gknd 10908 11 to to TO cord-010119-t1x9gknd 10908 12 reflect reflect VB cord-010119-t1x9gknd 10908 13 the the DT cord-010119-t1x9gknd 10908 14 latest late JJS cord-010119-t1x9gknd 10908 15 enhancements enhancement NNS cord-010119-t1x9gknd 10908 16 in in IN cord-010119-t1x9gknd 10908 17 transfusion transfusion NN cord-010119-t1x9gknd 10908 18 medicine medicine NN cord-010119-t1x9gknd 10908 19 . . . cord-010119-t1x9gknd 10909 1 Study Study NNP cord-010119-t1x9gknd 10909 2 Design Design NNP cord-010119-t1x9gknd 10909 3 / / SYM cord-010119-t1x9gknd 10909 4 Methods method NNS cord-010119-t1x9gknd 10909 5 : : : cord-010119-t1x9gknd 10909 6 41 41 CD cord-010119-t1x9gknd 10909 7 students student NNS cord-010119-t1x9gknd 10909 8 of of IN cord-010119-t1x9gknd 10909 9 undergraduate undergraduate NN cord-010119-t1x9gknd 10910 1 Semester semester NN cord-010119-t1x9gknd 10910 2 3 3 CD cord-010119-t1x9gknd 10910 3 and and CC cord-010119-t1x9gknd 10910 4 59 59 CD cord-010119-t1x9gknd 10910 5 students student NNS cord-010119-t1x9gknd 10910 6 of of IN cord-010119-t1x9gknd 10910 7 Semester Semester NNP cord-010119-t1x9gknd 10910 8 4 4 CD cord-010119-t1x9gknd 10910 9 participated participate VBD cord-010119-t1x9gknd 10910 10 in in IN cord-010119-t1x9gknd 10910 11 the the DT cord-010119-t1x9gknd 10910 12 study study NN cord-010119-t1x9gknd 10910 13 . . . cord-010119-t1x9gknd 10911 1 Self self NN cord-010119-t1x9gknd 10911 2 - - HYPH cord-010119-t1x9gknd 10911 3 directed direct VBN cord-010119-t1x9gknd 10911 4 learning learning NN cord-010119-t1x9gknd 10911 5 resources resource NNS cord-010119-t1x9gknd 10911 6 combined combine VBN cord-010119-t1x9gknd 10911 7 with with IN cord-010119-t1x9gknd 10911 8 modules module NNS cord-010119-t1x9gknd 10911 9 of of IN cord-010119-t1x9gknd 10911 10 interactive interactive JJ cord-010119-t1x9gknd 10911 11 instruction instruction NN cord-010119-t1x9gknd 10911 12 were be VBD cord-010119-t1x9gknd 10911 13 implemented implement VBN cord-010119-t1x9gknd 10911 14 in in IN cord-010119-t1x9gknd 10911 15 a a DT cord-010119-t1x9gknd 10911 16 TBL tbl NN cord-010119-t1x9gknd 10911 17 course course NN cord-010119-t1x9gknd 10911 18 design design NN cord-010119-t1x9gknd 10911 19 . . . cord-010119-t1x9gknd 10912 1 Five five CD cord-010119-t1x9gknd 10912 2 education education NN cord-010119-t1x9gknd 10912 3 modules module NNS cord-010119-t1x9gknd 10912 4 focusing focus VBG cord-010119-t1x9gknd 10912 5 on on IN cord-010119-t1x9gknd 10912 6 quality quality NN cord-010119-t1x9gknd 10912 7 management management NN cord-010119-t1x9gknd 10912 8 , , , cord-010119-t1x9gknd 10912 9 blood blood NN cord-010119-t1x9gknd 10912 10 collection collection NN cord-010119-t1x9gknd 10912 11 , , , cord-010119-t1x9gknd 10912 12 transfusion transfusion NN cord-010119-t1x9gknd 10912 13 reactions reaction NNS cord-010119-t1x9gknd 10912 14 , , , cord-010119-t1x9gknd 10912 15 precise precise JJ cord-010119-t1x9gknd 10912 16 utilization utilization NN cord-010119-t1x9gknd 10912 17 of of IN cord-010119-t1x9gknd 10912 18 blood blood NN cord-010119-t1x9gknd 10912 19 products product NNS cord-010119-t1x9gknd 10912 20 and and CC cord-010119-t1x9gknd 10912 21 innovations innovation NNS cord-010119-t1x9gknd 10912 22 in in IN cord-010119-t1x9gknd 10912 23 component component NN cord-010119-t1x9gknd 10912 24 safety safety NN cord-010119-t1x9gknd 10912 25 were be VBD cord-010119-t1x9gknd 10912 26 designed design VBN cord-010119-t1x9gknd 10912 27 for for IN cord-010119-t1x9gknd 10912 28 the the DT cord-010119-t1x9gknd 10912 29 students student NNS cord-010119-t1x9gknd 10912 30 . . . cord-010119-t1x9gknd 10913 1 The the DT cord-010119-t1x9gknd 10913 2 students student NNS cord-010119-t1x9gknd 10913 3 ' ' POS cord-010119-t1x9gknd 10913 4 reaction reaction NN cord-010119-t1x9gknd 10913 5 to to IN cord-010119-t1x9gknd 10913 6 TBL TBL NNP cord-010119-t1x9gknd 10913 7 in in IN cord-010119-t1x9gknd 10913 8 Transfusion Transfusion NNP cord-010119-t1x9gknd 10913 9 Medicine Medicine NNP cord-010119-t1x9gknd 10913 10 was be VBD cord-010119-t1x9gknd 10913 11 evaluated evaluate VBN cord-010119-t1x9gknd 10913 12 using use VBG cord-010119-t1x9gknd 10913 13 qualitative qualitative JJ cord-010119-t1x9gknd 10913 14 and and CC cord-010119-t1x9gknd 10913 15 quantitative quantitative JJ cord-010119-t1x9gknd 10913 16 assessment assessment NN cord-010119-t1x9gknd 10913 17 tools tool NNS cord-010119-t1x9gknd 10913 18 to to TO cord-010119-t1x9gknd 10913 19 analyze analyze VB cord-010119-t1x9gknd 10913 20 knowledge knowledge NN cord-010119-t1x9gknd 10913 21 attainment attainment JJ cord-010119-t1x9gknd 10913 22 and and CC cord-010119-t1x9gknd 10913 23 critical critical JJ cord-010119-t1x9gknd 10913 24 thinking thinking NN cord-010119-t1x9gknd 10913 25 development development NN cord-010119-t1x9gknd 10913 26 along along IN cord-010119-t1x9gknd 10913 27 with with IN cord-010119-t1x9gknd 10913 28 team team NN cord-010119-t1x9gknd 10913 29 continuity continuity NN cord-010119-t1x9gknd 10913 30 . . . cord-010119-t1x9gknd 10914 1 The the DT cord-010119-t1x9gknd 10914 2 participants participant NNS cord-010119-t1x9gknd 10914 3 were be VBD cord-010119-t1x9gknd 10914 4 first first RB cord-010119-t1x9gknd 10914 5 assessed assess VBN cord-010119-t1x9gknd 10914 6 with with IN cord-010119-t1x9gknd 10914 7 Readiness Readiness NNP cord-010119-t1x9gknd 10914 8 Assurance Assurance NNP cord-010119-t1x9gknd 10914 9 Testing Testing NNP cord-010119-t1x9gknd 10914 10 ( ( -LRB- cord-010119-t1x9gknd 10914 11 RAT rat NN cord-010119-t1x9gknd 10914 12 ) ) -RRB- cord-010119-t1x9gknd 10914 13 to to TO cord-010119-t1x9gknd 10914 14 guarantee guarantee VB cord-010119-t1x9gknd 10914 15 that that IN cord-010119-t1x9gknd 10914 16 they -PRON- PRP cord-010119-t1x9gknd 10914 17 understood understand VBD cord-010119-t1x9gknd 10914 18 the the DT cord-010119-t1x9gknd 10914 19 concepts concept NNS cord-010119-t1x9gknd 10914 20 and and CC cord-010119-t1x9gknd 10914 21 their -PRON- PRP$ cord-010119-t1x9gknd 10914 22 application application NN cord-010119-t1x9gknd 10914 23 followed follow VBN cord-010119-t1x9gknd 10914 24 by by IN cord-010119-t1x9gknd 10914 25 case case NN cord-010119-t1x9gknd 10914 26 study study NN cord-010119-t1x9gknd 10914 27 based base VBN cord-010119-t1x9gknd 10914 28 test test NN cord-010119-t1x9gknd 10914 29 questions question NNS cord-010119-t1x9gknd 10914 30 . . . cord-010119-t1x9gknd 10915 1 Results result NNS cord-010119-t1x9gknd 10915 2 / / SYM cord-010119-t1x9gknd 10915 3 Findings finding NNS cord-010119-t1x9gknd 10915 4 : : : cord-010119-t1x9gknd 10916 1 Students student NNS cord-010119-t1x9gknd 10916 2 ' ' POS cord-010119-t1x9gknd 10916 3 reaction reaction NN cord-010119-t1x9gknd 10916 4 to to IN cord-010119-t1x9gknd 10916 5 TBL TBL NNP cord-010119-t1x9gknd 10916 6 was be VBD cord-010119-t1x9gknd 10916 7 primarily primarily RB cord-010119-t1x9gknd 10916 8 positive positive JJ cord-010119-t1x9gknd 10916 9 , , , cord-010119-t1x9gknd 10916 10 with with IN cord-010119-t1x9gknd 10916 11 86 86 CD cord-010119-t1x9gknd 10916 12 % % NN cord-010119-t1x9gknd 10916 13 of of IN cord-010119-t1x9gknd 10916 14 students student NNS cord-010119-t1x9gknd 10916 15 giving give VBG cord-010119-t1x9gknd 10916 16 a a DT cord-010119-t1x9gknd 10916 17 positive positive JJ cord-010119-t1x9gknd 10916 18 feedback feedback NN cord-010119-t1x9gknd 10916 19 . . . cord-010119-t1x9gknd 10917 1 Evaluation evaluation NN cord-010119-t1x9gknd 10917 2 through through IN cord-010119-t1x9gknd 10917 3 Readiness Readiness NNP cord-010119-t1x9gknd 10917 4 Assurance Assurance NNP cord-010119-t1x9gknd 10917 5 Testing Testing NNP cord-010119-t1x9gknd 10917 6 ( ( -LRB- cord-010119-t1x9gknd 10917 7 RAT RAT NNP cord-010119-t1x9gknd 10917 8 ) ) -RRB- cord-010119-t1x9gknd 10917 9 illustrated illustrate VBD cord-010119-t1x9gknd 10917 10 improved improved JJ cord-010119-t1x9gknd 10917 11 team team NN cord-010119-t1x9gknd 10917 12 knowledge knowledge NN cord-010119-t1x9gknd 10917 13 acquisition acquisition NN cord-010119-t1x9gknd 10917 14 in in IN cord-010119-t1x9gknd 10917 15 implementation implementation NN cord-010119-t1x9gknd 10917 16 of of IN cord-010119-t1x9gknd 10917 17 effective effective JJ cord-010119-t1x9gknd 10917 18 quality quality NN cord-010119-t1x9gknd 10917 19 management management NN cord-010119-t1x9gknd 10917 20 systems system NNS cord-010119-t1x9gknd 10917 21 over over IN cord-010119-t1x9gknd 10917 22 knowledge knowledge NN cord-010119-t1x9gknd 10917 23 acquired acquire VBN cord-010119-t1x9gknd 10917 24 through through IN cord-010119-t1x9gknd 10917 25 individual individual JJ cord-010119-t1x9gknd 10917 26 study study NN cord-010119-t1x9gknd 10917 27 . . . cord-010119-t1x9gknd 10918 1 Students student NNS cord-010119-t1x9gknd 10918 2 grasped grasp VBD cord-010119-t1x9gknd 10918 3 a a DT cord-010119-t1x9gknd 10918 4 conceptual conceptual JJ cord-010119-t1x9gknd 10918 5 knowledge knowledge NN cord-010119-t1x9gknd 10918 6 of of IN cord-010119-t1x9gknd 10918 7 principles principle NNS cord-010119-t1x9gknd 10918 8 of of IN cord-010119-t1x9gknd 10918 9 transfusion transfusion NN cord-010119-t1x9gknd 10918 10 medicine medicine NN cord-010119-t1x9gknd 10918 11 and and CC cord-010119-t1x9gknd 10918 12 achieved achieve VBD cord-010119-t1x9gknd 10918 13 confidence confidence NN cord-010119-t1x9gknd 10918 14 in in IN cord-010119-t1x9gknd 10918 15 dealing deal VBG cord-010119-t1x9gknd 10918 16 with with IN cord-010119-t1x9gknd 10918 17 transfusion transfusion NN cord-010119-t1x9gknd 10918 18 - - HYPH cord-010119-t1x9gknd 10918 19 related relate VBN cord-010119-t1x9gknd 10918 20 complications complication NNS cord-010119-t1x9gknd 10918 21 . . . cord-010119-t1x9gknd 10919 1 Anecdotally anecdotally RB cord-010119-t1x9gknd 10919 2 , , , cord-010119-t1x9gknd 10919 3 students student NNS cord-010119-t1x9gknd 10919 4 significantly significantly RB cord-010119-t1x9gknd 10919 5 attained attain VBD cord-010119-t1x9gknd 10919 6 perception perception NN cord-010119-t1x9gknd 10919 7 in in IN cord-010119-t1x9gknd 10919 8 blood blood NN cord-010119-t1x9gknd 10919 9 component component NN cord-010119-t1x9gknd 10919 10 preparation preparation NN cord-010119-t1x9gknd 10919 11 , , , cord-010119-t1x9gknd 10919 12 storage storage NN cord-010119-t1x9gknd 10919 13 and and CC cord-010119-t1x9gknd 10919 14 their -PRON- PRP$ cord-010119-t1x9gknd 10919 15 optimal optimal JJ cord-010119-t1x9gknd 10919 16 utilization utilization NN cord-010119-t1x9gknd 10919 17 along along IN cord-010119-t1x9gknd 10919 18 with with IN cord-010119-t1x9gknd 10919 19 developments development NNS cord-010119-t1x9gknd 10919 20 in in IN cord-010119-t1x9gknd 10919 21 safety safety NN cord-010119-t1x9gknd 10919 22 techniques technique NNS cord-010119-t1x9gknd 10919 23 in in IN cord-010119-t1x9gknd 10919 24 blood blood NN cord-010119-t1x9gknd 10919 25 donation donation NN cord-010119-t1x9gknd 10919 26 . . . cord-010119-t1x9gknd 10920 1 Conclusion conclusion NN cord-010119-t1x9gknd 10920 2 : : : cord-010119-t1x9gknd 10921 1 Our -PRON- PRP$ cord-010119-t1x9gknd 10921 2 study study NN cord-010119-t1x9gknd 10921 3 suggests suggest VBZ cord-010119-t1x9gknd 10921 4 that that IN cord-010119-t1x9gknd 10921 5 reforming reform VBG cord-010119-t1x9gknd 10921 6 the the DT cord-010119-t1x9gknd 10921 7 medical medical JJ cord-010119-t1x9gknd 10921 8 curricula curricula NN cord-010119-t1x9gknd 10921 9 for for IN cord-010119-t1x9gknd 10921 10 undergraduate undergraduate JJ cord-010119-t1x9gknd 10921 11 medical medical JJ cord-010119-t1x9gknd 10921 12 students student NNS cord-010119-t1x9gknd 10921 13 , , , cord-010119-t1x9gknd 10921 14 with with IN cord-010119-t1x9gknd 10921 15 specific specific JJ cord-010119-t1x9gknd 10921 16 educational educational JJ cord-010119-t1x9gknd 10921 17 modules module NNS cord-010119-t1x9gknd 10921 18 designed design VBN cord-010119-t1x9gknd 10921 19 to to TO cord-010119-t1x9gknd 10921 20 focus focus VB cord-010119-t1x9gknd 10921 21 on on IN cord-010119-t1x9gknd 10921 22 blood blood NN cord-010119-t1x9gknd 10921 23 banking banking NN cord-010119-t1x9gknd 10921 24 and and CC cord-010119-t1x9gknd 10921 25 blood blood NN cord-010119-t1x9gknd 10921 26 transfusion transfusion NN cord-010119-t1x9gknd 10921 27 principles principle NNS cord-010119-t1x9gknd 10921 28 and and CC cord-010119-t1x9gknd 10921 29 latest late JJS cord-010119-t1x9gknd 10921 30 advances advance NNS cord-010119-t1x9gknd 10921 31 in in IN cord-010119-t1x9gknd 10921 32 transfusion transfusion NN cord-010119-t1x9gknd 10921 33 medicine medicine NN cord-010119-t1x9gknd 10921 34 , , , cord-010119-t1x9gknd 10921 35 is be VBZ cord-010119-t1x9gknd 10921 36 much much RB cord-010119-t1x9gknd 10921 37 required require VBN cord-010119-t1x9gknd 10921 38 in in IN cord-010119-t1x9gknd 10921 39 the the DT cord-010119-t1x9gknd 10921 40 interest interest NN cord-010119-t1x9gknd 10921 41 of of IN cord-010119-t1x9gknd 10921 42 patient patient JJ cord-010119-t1x9gknd 10921 43 care care NN cord-010119-t1x9gknd 10921 44 and and CC cord-010119-t1x9gknd 10921 45 safety safety NN cord-010119-t1x9gknd 10921 46 , , , cord-010119-t1x9gknd 10921 47 by by IN cord-010119-t1x9gknd 10921 48 the the DT cord-010119-t1x9gknd 10921 49 future future JJ cord-010119-t1x9gknd 10921 50 physicians physician NNS cord-010119-t1x9gknd 10921 51 . . . cord-010119-t1x9gknd 10922 1 TBL TBL NNP cord-010119-t1x9gknd 10922 2 is be VBZ cord-010119-t1x9gknd 10922 3 an an DT cord-010119-t1x9gknd 10922 4 interesting interesting JJ cord-010119-t1x9gknd 10922 5 and and CC cord-010119-t1x9gknd 10922 6 efficient efficient JJ cord-010119-t1x9gknd 10922 7 way way NN cord-010119-t1x9gknd 10922 8 to to TO cord-010119-t1x9gknd 10922 9 deliver deliver VB cord-010119-t1x9gknd 10922 10 the the DT cord-010119-t1x9gknd 10922 11 key key JJ cord-010119-t1x9gknd 10922 12 aspects aspect NNS cord-010119-t1x9gknd 10922 13 of of IN cord-010119-t1x9gknd 10922 14 transfusion transfusion NN cord-010119-t1x9gknd 10922 15 medicine medicine NN cord-010119-t1x9gknd 10922 16 to to IN cord-010119-t1x9gknd 10922 17 the the DT cord-010119-t1x9gknd 10922 18 students student NNS cord-010119-t1x9gknd 10922 19 . . . cord-010119-t1x9gknd 10923 1 Results/ Results/ . cord-010119-t1x9gknd 10924 1 Finding find VBG cord-010119-t1x9gknd 10925 1 : : : cord-010119-t1x9gknd 10925 2 Open open VB cord-010119-t1x9gknd 10925 3 house house NN cord-010119-t1x9gknd 10925 4 attendees attendee NNS cord-010119-t1x9gknd 10925 5 were be VBD cord-010119-t1x9gknd 10925 6 given give VBN cord-010119-t1x9gknd 10925 7 tours tour NNS cord-010119-t1x9gknd 10925 8 of of IN cord-010119-t1x9gknd 10925 9 the the DT cord-010119-t1x9gknd 10925 10 BB bb NN cord-010119-t1x9gknd 10925 11 , , , cord-010119-t1x9gknd 10925 12 led lead VBN cord-010119-t1x9gknd 10925 13 by by IN cord-010119-t1x9gknd 10925 14 a a DT cord-010119-t1x9gknd 10925 15 BB bb NN cord-010119-t1x9gknd 10925 16 attending attend VBG cord-010119-t1x9gknd 10925 17 , , , cord-010119-t1x9gknd 10925 18 BB BB NNP cord-010119-t1x9gknd 10925 19 residents resident NNS cord-010119-t1x9gknd 10925 20 , , , cord-010119-t1x9gknd 10925 21 BB BB NNP cord-010119-t1x9gknd 10925 22 supervisor supervisor NN cord-010119-t1x9gknd 10925 23 , , , cord-010119-t1x9gknd 10925 24 or or CC cord-010119-t1x9gknd 10925 25 BB BB NNP cord-010119-t1x9gknd 10925 26 Quality Quality NNP cord-010119-t1x9gknd 10925 27 Coordinator Coordinator NNP cord-010119-t1x9gknd 10925 28 . . . cord-010119-t1x9gknd 10926 1 The the DT cord-010119-t1x9gknd 10926 2 Patient Patient NNP cord-010119-t1x9gknd 10926 3 Blood Blood NNP cord-010119-t1x9gknd 10926 4 Management Management NNP cord-010119-t1x9gknd 10926 5 nurse nurse NN cord-010119-t1x9gknd 10926 6 was be VBD cord-010119-t1x9gknd 10926 7 also also RB cord-010119-t1x9gknd 10926 8 in in IN cord-010119-t1x9gknd 10926 9 attendance attendance NN cord-010119-t1x9gknd 10926 10 to to TO cord-010119-t1x9gknd 10926 11 answer answer VB cord-010119-t1x9gknd 10926 12 attendee attendee NN cord-010119-t1x9gknd 10926 13 questions question NNS cord-010119-t1x9gknd 10926 14 and and CC cord-010119-t1x9gknd 10926 15 educate educate VB cord-010119-t1x9gknd 10926 16 about about IN cord-010119-t1x9gknd 10926 17 Patient Patient NNP cord-010119-t1x9gknd 10926 18 Blood Blood NNP cord-010119-t1x9gknd 10926 19 Management Management NNP cord-010119-t1x9gknd 10926 20 . . . cord-010119-t1x9gknd 10927 1 Light light JJ cord-010119-t1x9gknd 10927 2 refreshments refreshment NNS cord-010119-t1x9gknd 10927 3 were be VBD cord-010119-t1x9gknd 10927 4 offered offer VBN cord-010119-t1x9gknd 10927 5 to to IN cord-010119-t1x9gknd 10927 6 the the DT cord-010119-t1x9gknd 10927 7 attendees attendee NNS cord-010119-t1x9gknd 10927 8 in in IN cord-010119-t1x9gknd 10927 9 the the DT cord-010119-t1x9gknd 10927 10 BB BB NNP cord-010119-t1x9gknd 10927 11 break break NN cord-010119-t1x9gknd 10927 12 room room NN cord-010119-t1x9gknd 10927 13 . . . cord-010119-t1x9gknd 10928 1 The the DT cord-010119-t1x9gknd 10928 2 first first JJ cord-010119-t1x9gknd 10928 3 BB BB NNP cord-010119-t1x9gknd 10928 4 open open JJ cord-010119-t1x9gknd 10928 5 house house NN cord-010119-t1x9gknd 10928 6 was be VBD cord-010119-t1x9gknd 10928 7 held hold VBN cord-010119-t1x9gknd 10928 8 on on IN cord-010119-t1x9gknd 10928 9 Wednesday Wednesday NNP cord-010119-t1x9gknd 10928 10 , , , cord-010119-t1x9gknd 10928 11 12/7/16 12/7/16 JJ cord-010119-t1x9gknd 10928 12 from from IN cord-010119-t1x9gknd 10928 13 9 9 CD cord-010119-t1x9gknd 10928 14 - - SYM cord-010119-t1x9gknd 10928 15 11am 11am NN cord-010119-t1x9gknd 10928 16 . . . cord-010119-t1x9gknd 10929 1 There there EX cord-010119-t1x9gknd 10929 2 were be VBD cord-010119-t1x9gknd 10929 3 17 17 CD cord-010119-t1x9gknd 10929 4 attendees attendee NNS cord-010119-t1x9gknd 10929 5 , , , cord-010119-t1x9gknd 10929 6 including include VBG cord-010119-t1x9gknd 10929 7 a a DT cord-010119-t1x9gknd 10929 8 second second JJ cord-010119-t1x9gknd 10929 9 - - HYPH cord-010119-t1x9gknd 10929 10 year year NN cord-010119-t1x9gknd 10929 11 medical medical JJ cord-010119-t1x9gknd 10929 12 student student NN cord-010119-t1x9gknd 10929 13 , , , cord-010119-t1x9gknd 10929 14 four four CD cord-010119-t1x9gknd 10929 15 regular regular JJ cord-010119-t1x9gknd 10929 16 blood blood NN cord-010119-t1x9gknd 10929 17 donors donor NNS cord-010119-t1x9gknd 10929 18 at at IN cord-010119-t1x9gknd 10929 19 the the DT cord-010119-t1x9gknd 10929 20 hospital hospital NN cord-010119-t1x9gknd 10929 21 blood blood NN cord-010119-t1x9gknd 10929 22 donor donor NN cord-010119-t1x9gknd 10929 23 center center NN cord-010119-t1x9gknd 10929 24 ( ( -LRB- cord-010119-t1x9gknd 10929 25 who who WP cord-010119-t1x9gknd 10929 26 were be VBD cord-010119-t1x9gknd 10929 27 also also RB cord-010119-t1x9gknd 10929 28 employees employee NNS cord-010119-t1x9gknd 10929 29 in in IN cord-010119-t1x9gknd 10929 30 Facilities Facilities NNPS cord-010119-t1x9gknd 10929 31 Management Management NNP cord-010119-t1x9gknd 10929 32 and and CC cord-010119-t1x9gknd 10929 33 the the DT cord-010119-t1x9gknd 10929 34 University University NNP cord-010119-t1x9gknd 10929 35 Office Office NNP cord-010119-t1x9gknd 10929 36 of of IN cord-010119-t1x9gknd 10929 37 Admissions Admissions NNPS cord-010119-t1x9gknd 10929 38 , , , cord-010119-t1x9gknd 10929 39 respectively respectively RB cord-010119-t1x9gknd 10929 40 ) ) -RRB- cord-010119-t1x9gknd 10929 41 , , , cord-010119-t1x9gknd 10929 42 a a DT cord-010119-t1x9gknd 10929 43 hospital hospital NN cord-010119-t1x9gknd 10929 44 senior senior JJ cord-010119-t1x9gknd 10929 45 vice vice NN cord-010119-t1x9gknd 10929 46 - - HYPH cord-010119-t1x9gknd 10929 47 president president NN cord-010119-t1x9gknd 10929 48 , , , cord-010119-t1x9gknd 10929 49 six six CD cord-010119-t1x9gknd 10929 50 apheresis apheresis NN cord-010119-t1x9gknd 10929 51 nurses nurse NNS cord-010119-t1x9gknd 10929 52 , , , cord-010119-t1x9gknd 10929 53 two two CD cord-010119-t1x9gknd 10929 54 clinical clinical JJ cord-010119-t1x9gknd 10929 55 laboratory laboratory NN cord-010119-t1x9gknd 10929 56 staff staff NN cord-010119-t1x9gknd 10929 57 , , , cord-010119-t1x9gknd 10929 58 two two CD cord-010119-t1x9gknd 10929 59 medical medical JJ cord-010119-t1x9gknd 10929 60 laboratory laboratory NN cord-010119-t1x9gknd 10929 61 science science NN cord-010119-t1x9gknd 10929 62 students student NNS cord-010119-t1x9gknd 10929 63 , , , cord-010119-t1x9gknd 10929 64 and and CC cord-010119-t1x9gknd 10929 65 one one CD cord-010119-t1x9gknd 10929 66 additional additional JJ cord-010119-t1x9gknd 10929 67 staff staff NN cord-010119-t1x9gknd 10929 68 member member NN cord-010119-t1x9gknd 10929 69 from from IN cord-010119-t1x9gknd 10929 70 the the DT cord-010119-t1x9gknd 10929 71 University University NNP cord-010119-t1x9gknd 10929 72 Office Office NNP cord-010119-t1x9gknd 10929 73 of of IN cord-010119-t1x9gknd 10929 74 Admissions Admissions NNPS cord-010119-t1x9gknd 10929 75 . . . cord-010119-t1x9gknd 10930 1 The the DT cord-010119-t1x9gknd 10930 2 second second JJ cord-010119-t1x9gknd 10930 3 BB BB NNP cord-010119-t1x9gknd 10930 4 open open JJ cord-010119-t1x9gknd 10930 5 house house NN cord-010119-t1x9gknd 10930 6 was be VBD cord-010119-t1x9gknd 10930 7 held hold VBN cord-010119-t1x9gknd 10930 8 on on IN cord-010119-t1x9gknd 10930 9 Thursday Thursday NNP cord-010119-t1x9gknd 10930 10 , , , cord-010119-t1x9gknd 10930 11 4/20/17 4/20/17 CD cord-010119-t1x9gknd 10930 12 from from IN cord-010119-t1x9gknd 10930 13 7 7 CD cord-010119-t1x9gknd 10930 14 - - SYM cord-010119-t1x9gknd 10930 15 11am 11am NN cord-010119-t1x9gknd 10930 16 . . . cord-010119-t1x9gknd 10931 1 There there EX cord-010119-t1x9gknd 10931 2 were be VBD cord-010119-t1x9gknd 10931 3 14 14 CD cord-010119-t1x9gknd 10931 4 attendees attendee NNS cord-010119-t1x9gknd 10931 5 , , , cord-010119-t1x9gknd 10931 6 including include VBG cord-010119-t1x9gknd 10931 7 2 2 CD cord-010119-t1x9gknd 10931 8 regular regular JJ cord-010119-t1x9gknd 10931 9 blood blood NN cord-010119-t1x9gknd 10931 10 donors donor NNS cord-010119-t1x9gknd 10931 11 ( ( -LRB- cord-010119-t1x9gknd 10931 12 who who WP cord-010119-t1x9gknd 10931 13 were be VBD cord-010119-t1x9gknd 10931 14 also also RB cord-010119-t1x9gknd 10931 15 employees employee NNS cord-010119-t1x9gknd 10931 16 in in IN cord-010119-t1x9gknd 10931 17 the the DT cord-010119-t1x9gknd 10931 18 Office Office NNP cord-010119-t1x9gknd 10931 19 of of IN cord-010119-t1x9gknd 10931 20 International International NNP cord-010119-t1x9gknd 10931 21 Affairs Affairs NNPS cord-010119-t1x9gknd 10931 22 and and CC cord-010119-t1x9gknd 10931 23 Supply Supply NNP cord-010119-t1x9gknd 10931 24 Chain Chain NNP cord-010119-t1x9gknd 10931 25 , , , cord-010119-t1x9gknd 10931 26 respectively respectively RB cord-010119-t1x9gknd 10931 27 ) ) -RRB- cord-010119-t1x9gknd 10931 28 , , , cord-010119-t1x9gknd 10931 29 a a DT cord-010119-t1x9gknd 10931 30 hematology hematology NN cord-010119-t1x9gknd 10931 31 / / SYM cord-010119-t1x9gknd 10931 32 oncology oncology NN cord-010119-t1x9gknd 10931 33 fellow fellow NN cord-010119-t1x9gknd 10931 34 , , , cord-010119-t1x9gknd 10931 35 and and CC cord-010119-t1x9gknd 10931 36 11 11 CD cord-010119-t1x9gknd 10931 37 surgical surgical JJ cord-010119-t1x9gknd 10931 38 residents resident NNS cord-010119-t1x9gknd 10931 39 . . . cord-010119-t1x9gknd 10932 1 Background Background NNP cord-010119-t1x9gknd 10932 2 / / SYM cord-010119-t1x9gknd 10932 3 Case Case NNP cord-010119-t1x9gknd 10932 4 Studies Studies NNPS cord-010119-t1x9gknd 10932 5 : : : cord-010119-t1x9gknd 10933 1 Simple simple JJ cord-010119-t1x9gknd 10933 2 , , , cord-010119-t1x9gknd 10933 3 partial partial JJ cord-010119-t1x9gknd 10933 4 , , , cord-010119-t1x9gknd 10933 5 and and CC cord-010119-t1x9gknd 10933 6 exchange exchange NN cord-010119-t1x9gknd 10933 7 transfusions transfusion NNS cord-010119-t1x9gknd 10933 8 are be VBP cord-010119-t1x9gknd 10933 9 routinely routinely RB cord-010119-t1x9gknd 10933 10 performed perform VBN cord-010119-t1x9gknd 10933 11 in in IN cord-010119-t1x9gknd 10933 12 patients patient NNS cord-010119-t1x9gknd 10933 13 with with IN cord-010119-t1x9gknd 10933 14 sickle sickle NN cord-010119-t1x9gknd 10933 15 - - HYPH cord-010119-t1x9gknd 10933 16 cell cell NN cord-010119-t1x9gknd 10933 17 disease disease NN cord-010119-t1x9gknd 10933 18 ( ( -LRB- cord-010119-t1x9gknd 10933 19 SCD SCD NNP cord-010119-t1x9gknd 10933 20 ) ) -RRB- cord-010119-t1x9gknd 10933 21 with with IN cord-010119-t1x9gknd 10933 22 the the DT cord-010119-t1x9gknd 10933 23 goal goal NN cord-010119-t1x9gknd 10933 24 to to TO cord-010119-t1x9gknd 10933 25 increase increase VB cord-010119-t1x9gknd 10933 26 the the DT cord-010119-t1x9gknd 10933 27 oxygen oxygen NN cord-010119-t1x9gknd 10933 28 carrying carrying NN cord-010119-t1x9gknd 10933 29 capacity capacity NN cord-010119-t1x9gknd 10933 30 of of IN cord-010119-t1x9gknd 10933 31 the the DT cord-010119-t1x9gknd 10933 32 blood blood NN cord-010119-t1x9gknd 10933 33 and and CC cord-010119-t1x9gknd 10933 34 reduce reduce VB cord-010119-t1x9gknd 10933 35 the the DT cord-010119-t1x9gknd 10933 36 relative relative JJ cord-010119-t1x9gknd 10933 37 percentage percentage NN cord-010119-t1x9gknd 10933 38 of of IN cord-010119-t1x9gknd 10933 39 sickled sickled JJ cord-010119-t1x9gknd 10933 40 cells cell NNS cord-010119-t1x9gknd 10933 41 . . . cord-010119-t1x9gknd 10934 1 It -PRON- PRP cord-010119-t1x9gknd 10934 2 is be VBZ cord-010119-t1x9gknd 10934 3 essential essential JJ cord-010119-t1x9gknd 10934 4 for for IN cord-010119-t1x9gknd 10934 5 clinicians clinician NNS cord-010119-t1x9gknd 10934 6 to to TO cord-010119-t1x9gknd 10934 7 be be VB cord-010119-t1x9gknd 10934 8 able able JJ cord-010119-t1x9gknd 10934 9 to to TO cord-010119-t1x9gknd 10934 10 rapidly rapidly RB cord-010119-t1x9gknd 10934 11 estimate estimate VB cord-010119-t1x9gknd 10934 12 the the DT cord-010119-t1x9gknd 10934 13 effects effect NNS cord-010119-t1x9gknd 10934 14 of of IN cord-010119-t1x9gknd 10934 15 the the DT cord-010119-t1x9gknd 10934 16 available available JJ cord-010119-t1x9gknd 10934 17 therapeutic therapeutic JJ cord-010119-t1x9gknd 10934 18 modalities modality NNS cord-010119-t1x9gknd 10934 19 using use VBG cord-010119-t1x9gknd 10934 20 clinical clinical JJ cord-010119-t1x9gknd 10934 21 information information NN cord-010119-t1x9gknd 10934 22 to to TO cord-010119-t1x9gknd 10934 23 minimize minimize VB cord-010119-t1x9gknd 10934 24 the the DT cord-010119-t1x9gknd 10934 25 risk risk NN cord-010119-t1x9gknd 10934 26 of of IN cord-010119-t1x9gknd 10934 27 red red JJ cord-010119-t1x9gknd 10934 28 blood blood NN cord-010119-t1x9gknd 10934 29 cell cell NN cord-010119-t1x9gknd 10934 30 exposure exposure NN cord-010119-t1x9gknd 10934 31 . . . cord-010119-t1x9gknd 10935 1 Given give VBN cord-010119-t1x9gknd 10935 2 that that IN cord-010119-t1x9gknd 10935 3 the the DT cord-010119-t1x9gknd 10935 4 formulas formula NNS cord-010119-t1x9gknd 10935 5 for for IN cord-010119-t1x9gknd 10935 6 these these DT cord-010119-t1x9gknd 10935 7 calculations calculation NNS cord-010119-t1x9gknd 10935 8 are be VBP cord-010119-t1x9gknd 10935 9 complicated complicated JJ cord-010119-t1x9gknd 10935 10 , , , cord-010119-t1x9gknd 10935 11 we -PRON- PRP cord-010119-t1x9gknd 10935 12 developed develop VBD cord-010119-t1x9gknd 10935 13 and and CC cord-010119-t1x9gknd 10935 14 validated validate VBD cord-010119-t1x9gknd 10935 15 an an DT cord-010119-t1x9gknd 10935 16 online online JJ cord-010119-t1x9gknd 10935 17 calculator calculator NN cord-010119-t1x9gknd 10935 18 to to TO cord-010119-t1x9gknd 10935 19 assist assist VB cord-010119-t1x9gknd 10935 20 physicians physician NNS cord-010119-t1x9gknd 10935 21 with with IN cord-010119-t1x9gknd 10935 22 such such JJ cord-010119-t1x9gknd 10935 23 tasks task NNS cord-010119-t1x9gknd 10935 24 . . . cord-010119-t1x9gknd 10936 1 Study Study NNP cord-010119-t1x9gknd 10936 2 Design Design NNP cord-010119-t1x9gknd 10936 3 / / SYM cord-010119-t1x9gknd 10936 4 Method method NN cord-010119-t1x9gknd 10936 5 : : : cord-010119-t1x9gknd 10937 1 A a DT cord-010119-t1x9gknd 10937 2 web web NN cord-010119-t1x9gknd 10937 3 application application NN cord-010119-t1x9gknd 10937 4 was be VBD cord-010119-t1x9gknd 10937 5 generated generate VBN cord-010119-t1x9gknd 10937 6 ( ( -LRB- cord-010119-t1x9gknd 10937 7 www.Phamcalcs.com www.phamcalcs.com ADD cord-010119-t1x9gknd 10937 8 ) ) -RRB- cord-010119-t1x9gknd 10937 9 . . . cord-010119-t1x9gknd 10938 1 The the DT cord-010119-t1x9gknd 10938 2 performance performance NN cord-010119-t1x9gknd 10938 3 of of IN cord-010119-t1x9gknd 10938 4 the the DT cord-010119-t1x9gknd 10938 5 simple simple JJ cord-010119-t1x9gknd 10938 6 transfusion transfusion NN cord-010119-t1x9gknd 10938 7 and and CC cord-010119-t1x9gknd 10938 8 partial partial JJ cord-010119-t1x9gknd 10938 9 manual manual JJ cord-010119-t1x9gknd 10938 10 exchange exchange NN cord-010119-t1x9gknd 10938 11 calculators calculator NNS cord-010119-t1x9gknd 10938 12 were be VBD cord-010119-t1x9gknd 10938 13 validated validate VBN cord-010119-t1x9gknd 10938 14 by by IN cord-010119-t1x9gknd 10938 15 comparing compare VBG cord-010119-t1x9gknd 10938 16 the the DT cord-010119-t1x9gknd 10938 17 predictions prediction NNS cord-010119-t1x9gknd 10938 18 to to IN cord-010119-t1x9gknd 10938 19 clinical clinical JJ cord-010119-t1x9gknd 10938 20 data datum NNS cord-010119-t1x9gknd 10938 21 . . . cord-010119-t1x9gknd 10939 1 The the DT cord-010119-t1x9gknd 10939 2 performance performance NN cord-010119-t1x9gknd 10939 3 of of IN cord-010119-t1x9gknd 10939 4 the the DT cord-010119-t1x9gknd 10939 5 automated automate VBN cord-010119-t1x9gknd 10939 6 and and CC cord-010119-t1x9gknd 10939 7 depletion depletion NN cord-010119-t1x9gknd 10939 8 RBCx rbcx NN cord-010119-t1x9gknd 10939 9 calculators calculator NNS cord-010119-t1x9gknd 10939 10 was be VBD cord-010119-t1x9gknd 10939 11 validated validate VBN cord-010119-t1x9gknd 10939 12 using use VBG cord-010119-t1x9gknd 10939 13 the the DT cord-010119-t1x9gknd 10939 14 Terumo Terumo NNP cord-010119-t1x9gknd 10939 15 BCT BCT NNP cord-010119-t1x9gknd 10939 16 ( ( -LRB- cord-010119-t1x9gknd 10939 17 Lakewood Lakewood NNP cord-010119-t1x9gknd 10939 18 , , , cord-010119-t1x9gknd 10939 19 CO CO NNP cord-010119-t1x9gknd 10939 20 ) ) -RRB- cord-010119-t1x9gknd 10939 21 calculator calculator VB cord-010119-t1x9gknd 10939 22 up up RP cord-010119-t1x9gknd 10939 23 to to IN cord-010119-t1x9gknd 10939 24 a a DT cord-010119-t1x9gknd 10939 25 fraction fraction NN cord-010119-t1x9gknd 10939 26 cells cell NNS cord-010119-t1x9gknd 10939 27 remaining remain VBG cord-010119-t1x9gknd 10939 28 ( ( -LRB- cord-010119-t1x9gknd 10939 29 FCR FCR NNP cord-010119-t1x9gknd 10939 30 ) ) -RRB- cord-010119-t1x9gknd 10939 31 50 50 CD cord-010119-t1x9gknd 10939 32 % % NN cord-010119-t1x9gknd 10939 33 as as IN cord-010119-t1x9gknd 10939 34 patients patient NNS cord-010119-t1x9gknd 10939 35 with with IN cord-010119-t1x9gknd 10939 36 FCR FCR NNP cord-010119-t1x9gknd 10939 37 50 50 CD cord-010119-t1x9gknd 10939 38 % % NN cord-010119-t1x9gknd 10939 39 may may MD cord-010119-t1x9gknd 10939 40 benefit benefit VB cord-010119-t1x9gknd 10939 41 from from IN cord-010119-t1x9gknd 10939 42 delaying delay VBG cord-010119-t1x9gknd 10939 43 the the DT cord-010119-t1x9gknd 10939 44 procedure procedure NN cord-010119-t1x9gknd 10939 45 for for IN cord-010119-t1x9gknd 10939 46 performance performance NN cord-010119-t1x9gknd 10939 47 in in IN cord-010119-t1x9gknd 10939 48 the the DT cord-010119-t1x9gknd 10939 49 future future NN cord-010119-t1x9gknd 10939 50 . . . cord-010119-t1x9gknd 10940 1 Validation validation NN cord-010119-t1x9gknd 10940 2 process process NN cord-010119-t1x9gknd 10940 3 included include VBD cord-010119-t1x9gknd 10940 4 ( ( -LRB- cord-010119-t1x9gknd 10940 5 1 1 CD cord-010119-t1x9gknd 10940 6 ) ) -RRB- cord-010119-t1x9gknd 10940 7 a a DT cord-010119-t1x9gknd 10940 8 Deming Deming NNP cord-010119-t1x9gknd 10940 9 regression regression NN cord-010119-t1x9gknd 10940 10 to to TO cord-010119-t1x9gknd 10940 11 globally globally RB cord-010119-t1x9gknd 10940 12 assess assess VB cord-010119-t1x9gknd 10940 13 the the DT cord-010119-t1x9gknd 10940 14 predicted predict VBN cord-010119-t1x9gknd 10940 15 vs. vs. IN cord-010119-t1x9gknd 10940 16 actual actual JJ cord-010119-t1x9gknd 10940 17 results result NNS cord-010119-t1x9gknd 10940 18 and and CC cord-010119-t1x9gknd 10940 19 ( ( -LRB- cord-010119-t1x9gknd 10940 20 2 2 LS cord-010119-t1x9gknd 10940 21 ) ) -RRB- cord-010119-t1x9gknd 10940 22 an an DT cord-010119-t1x9gknd 10940 23 individual individual JJ cord-010119-t1x9gknd 10940 24 comparison comparison NN cord-010119-t1x9gknd 10940 25 wherein wherein WRB cord-010119-t1x9gknd 10940 26 validation validation NN cord-010119-t1x9gknd 10940 27 was be VBD cord-010119-t1x9gknd 10940 28 contingent contingent JJ cord-010119-t1x9gknd 10940 29 on on IN cord-010119-t1x9gknd 10940 30 the the DT cord-010119-t1x9gknd 10940 31 ( ( -LRB- cord-010119-t1x9gknd 10940 32 predicted predict VBN cord-010119-t1x9gknd 10940 33 - - HYPH cord-010119-t1x9gknd 10940 34 expected expect VBN cord-010119-t1x9gknd 10940 35 results)/(expected results)/(expected NNP cord-010119-t1x9gknd 10940 36 results result NNS cord-010119-t1x9gknd 10940 37 ) ) -RRB- cord-010119-t1x9gknd 10940 38 demonstrating demonstrate VBG cord-010119-t1x9gknd 10940 39 |D| |D| NNP cord-010119-t1x9gknd 10940 40 15 15 CD cord-010119-t1x9gknd 10940 41 % % NN cord-010119-t1x9gknd 10940 42 . . . cord-010119-t1x9gknd 10941 1 Validation validation NN cord-010119-t1x9gknd 10941 2 was be VBD cord-010119-t1x9gknd 10941 3 performed perform VBN cord-010119-t1x9gknd 10941 4 for for IN cord-010119-t1x9gknd 10941 5 hematocrit hematocrit NN cord-010119-t1x9gknd 10941 6 ( ( -LRB- cord-010119-t1x9gknd 10941 7 Hct hct NN cord-010119-t1x9gknd 10941 8 ) ) -RRB- cord-010119-t1x9gknd 10941 9 and and CC cord-010119-t1x9gknd 10941 10 hemoglobin hemoglobin NN cord-010119-t1x9gknd 10941 11 S S NNP cord-010119-t1x9gknd 10941 12 ( ( -LRB- cord-010119-t1x9gknd 10941 13 HgbS HgbS NNP cord-010119-t1x9gknd 10941 14 ) ) -RRB- cord-010119-t1x9gknd 10941 15 level level JJ cord-010119-t1x9gknd 10941 16 post post NN cord-010119-t1x9gknd 10941 17 - - NN cord-010119-t1x9gknd 10941 18 transfusion transfusion NN cord-010119-t1x9gknd 10941 19 for for IN cord-010119-t1x9gknd 10941 20 simple simple JJ cord-010119-t1x9gknd 10941 21 and and CC cord-010119-t1x9gknd 10941 22 partial partial JJ cord-010119-t1x9gknd 10941 23 manual manual JJ cord-010119-t1x9gknd 10941 24 exchange exchange NN cord-010119-t1x9gknd 10941 25 and and CC cord-010119-t1x9gknd 10941 26 volume volume NN cord-010119-t1x9gknd 10941 27 of of IN cord-010119-t1x9gknd 10941 28 replacement replacement NN cord-010119-t1x9gknd 10941 29 fluid fluid NN cord-010119-t1x9gknd 10941 30 for for IN cord-010119-t1x9gknd 10941 31 automated automated JJ cord-010119-t1x9gknd 10941 32 and and CC cord-010119-t1x9gknd 10941 33 depletion depletion NN cord-010119-t1x9gknd 10941 34 RBC RBC NNP cord-010119-t1x9gknd 10941 35 exchange exchange NN cord-010119-t1x9gknd 10941 36 . . . cord-010119-t1x9gknd 10942 1 Results result NNS cord-010119-t1x9gknd 10943 1 /Finding /finde VBG cord-010119-t1x9gknd 10943 2 : : : cord-010119-t1x9gknd 10944 1 See see VB cord-010119-t1x9gknd 10944 2 Table table NN cord-010119-t1x9gknd 10944 3 1 1 CD cord-010119-t1x9gknd 10945 1 Background Background NNP cord-010119-t1x9gknd 10945 2 / / SYM cord-010119-t1x9gknd 10945 3 Case Case NNP cord-010119-t1x9gknd 10945 4 Studies Studies NNPS cord-010119-t1x9gknd 10945 5 : : : cord-010119-t1x9gknd 10945 6 With with IN cord-010119-t1x9gknd 10945 7 the the DT cord-010119-t1x9gknd 10945 8 focus focus NN cord-010119-t1x9gknd 10945 9 on on IN cord-010119-t1x9gknd 10945 10 new new JJ cord-010119-t1x9gknd 10945 11 technologies technology NNS cord-010119-t1x9gknd 10945 12 the the DT cord-010119-t1x9gknd 10945 13 modern modern JJ cord-010119-t1x9gknd 10945 14 medicine medicine NN cord-010119-t1x9gknd 10945 15 requires require VBZ cord-010119-t1x9gknd 10945 16 more more JJR cord-010119-t1x9gknd 10945 17 expenses expense NNS cord-010119-t1x9gknd 10945 18 . . . cord-010119-t1x9gknd 10946 1 Despite despite IN cord-010119-t1x9gknd 10946 2 the the DT cord-010119-t1x9gknd 10946 3 increase increase NN cord-010119-t1x9gknd 10946 4 in in IN cord-010119-t1x9gknd 10946 5 the the DT cord-010119-t1x9gknd 10946 6 target target NN cord-010119-t1x9gknd 10946 7 impact impact NN cord-010119-t1x9gknd 10946 8 on on IN cord-010119-t1x9gknd 10946 9 patients patient NNS cord-010119-t1x9gknd 10946 10 there there EX cord-010119-t1x9gknd 10946 11 is be VBZ cord-010119-t1x9gknd 10946 12 still still RB cord-010119-t1x9gknd 10946 13 a a DT cord-010119-t1x9gknd 10946 14 risk risk NN cord-010119-t1x9gknd 10946 15 of of IN cord-010119-t1x9gknd 10946 16 adverse adverse JJ cord-010119-t1x9gknd 10946 17 reactions reaction NNS cord-010119-t1x9gknd 10946 18 to to IN cord-010119-t1x9gknd 10946 19 medical medical JJ cord-010119-t1x9gknd 10946 20 treatment treatment NN cord-010119-t1x9gknd 10946 21 . . . cord-010119-t1x9gknd 10947 1 The the DT cord-010119-t1x9gknd 10947 2 issues issue NNS cord-010119-t1x9gknd 10947 3 that that WDT cord-010119-t1x9gknd 10947 4 are be VBP cord-010119-t1x9gknd 10947 5 currently currently RB cord-010119-t1x9gknd 10947 6 under under IN cord-010119-t1x9gknd 10947 7 discussion discussion NN cord-010119-t1x9gknd 10947 8 : : : cord-010119-t1x9gknd 10947 9 the the DT cord-010119-t1x9gknd 10947 10 use use NN cord-010119-t1x9gknd 10947 11 of of IN cord-010119-t1x9gknd 10947 12 standardized standardized JJ cord-010119-t1x9gknd 10947 13 or or CC cord-010119-t1x9gknd 10947 14 personalized personalized JJ cord-010119-t1x9gknd 10947 15 approach approach NN cord-010119-t1x9gknd 10947 16 , , , cord-010119-t1x9gknd 10947 17 for for IN cord-010119-t1x9gknd 10947 18 doctors doctor NNS cord-010119-t1x9gknd 10947 19 -being -bee VBG cord-010119-t1x9gknd 10947 20 multidisciplinary multidisciplinary NN cord-010119-t1x9gknd 10947 21 or or CC cord-010119-t1x9gknd 10947 22 having have VBG cord-010119-t1x9gknd 10947 23 a a DT cord-010119-t1x9gknd 10947 24 narrow narrow JJ cord-010119-t1x9gknd 10947 25 specialization specialization NN cord-010119-t1x9gknd 10947 26 , , , cord-010119-t1x9gknd 10947 27 integration integration NN cord-010119-t1x9gknd 10947 28 of of IN cord-010119-t1x9gknd 10947 29 new new JJ cord-010119-t1x9gknd 10947 30 technologies technology NNS cord-010119-t1x9gknd 10947 31 , , , cord-010119-t1x9gknd 10947 32 the the DT cord-010119-t1x9gknd 10947 33 need need NN cord-010119-t1x9gknd 10947 34 for for IN cord-010119-t1x9gknd 10947 35 more more JJR cord-010119-t1x9gknd 10947 36 trainings training NNS cord-010119-t1x9gknd 10947 37 resulted result VBD cord-010119-t1x9gknd 10947 38 from from IN cord-010119-t1x9gknd 10947 39 knowledge knowledge NN cord-010119-t1x9gknd 10947 40 deficiency deficiency NN cord-010119-t1x9gknd 10947 41 . . . cord-010119-t1x9gknd 10948 1 In in IN cord-010119-t1x9gknd 10948 2 Russia Russia NNP cord-010119-t1x9gknd 10948 3 , , , cord-010119-t1x9gknd 10948 4 the the DT cord-010119-t1x9gknd 10948 5 development development NN cord-010119-t1x9gknd 10948 6 of of IN cord-010119-t1x9gknd 10948 7 insurance insurance NN cord-010119-t1x9gknd 10948 8 medicine medicine NN cord-010119-t1x9gknd 10948 9 creates create VBZ cord-010119-t1x9gknd 10948 10 the the DT cord-010119-t1x9gknd 10948 11 demand demand NN cord-010119-t1x9gknd 10948 12 for for IN cord-010119-t1x9gknd 10948 13 more more RBR cord-010119-t1x9gknd 10948 14 intensive intensive JJ cord-010119-t1x9gknd 10948 15 and and CC cord-010119-t1x9gknd 10948 16 cost cost NN cord-010119-t1x9gknd 10948 17 - - HYPH cord-010119-t1x9gknd 10948 18 effective effective JJ cord-010119-t1x9gknd 10948 19 treatment treatment NN cord-010119-t1x9gknd 10948 20 programs program NNS cord-010119-t1x9gknd 10948 21 . . . cord-010119-t1x9gknd 10949 1 As as IN cord-010119-t1x9gknd 10949 2 a a DT cord-010119-t1x9gknd 10949 3 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 10949 4 approach approach NN cord-010119-t1x9gknd 10949 5 , , , cord-010119-t1x9gknd 10949 6 PBM PBM NNP cord-010119-t1x9gknd 10949 7 optimizes optimize VBZ cord-010119-t1x9gknd 10949 8 the the DT cord-010119-t1x9gknd 10949 9 transfusion transfusion NN cord-010119-t1x9gknd 10949 10 practice practice NN cord-010119-t1x9gknd 10949 11 reducing reduce VBG cord-010119-t1x9gknd 10949 12 the the DT cord-010119-t1x9gknd 10949 13 risk risk NN cord-010119-t1x9gknd 10949 14 of of IN cord-010119-t1x9gknd 10949 15 adverse adverse JJ cord-010119-t1x9gknd 10949 16 effects effect NNS cord-010119-t1x9gknd 10949 17 and and CC cord-010119-t1x9gknd 10949 18 improving improve VBG cord-010119-t1x9gknd 10949 19 the the DT cord-010119-t1x9gknd 10949 20 financial financial JJ cord-010119-t1x9gknd 10949 21 performance performance NN cord-010119-t1x9gknd 10949 22 of of IN cord-010119-t1x9gknd 10949 23 a a DT cord-010119-t1x9gknd 10949 24 health health NN cord-010119-t1x9gknd 10949 25 care care NN cord-010119-t1x9gknd 10949 26 institution institution NN cord-010119-t1x9gknd 10949 27 . . . cord-010119-t1x9gknd 10950 1 However however RB cord-010119-t1x9gknd 10950 2 , , , cord-010119-t1x9gknd 10950 3 the the DT cord-010119-t1x9gknd 10950 4 prosperous prosperous JJ cord-010119-t1x9gknd 10950 5 implementation implementation NN cord-010119-t1x9gknd 10950 6 of of IN cord-010119-t1x9gknd 10950 7 PBM PBM NNP cord-010119-t1x9gknd 10950 8 also also RB cord-010119-t1x9gknd 10950 9 requires require VBZ cord-010119-t1x9gknd 10950 10 supplemental supplemental JJ cord-010119-t1x9gknd 10950 11 medical medical JJ cord-010119-t1x9gknd 10950 12 competencies competency NNS cord-010119-t1x9gknd 10950 13 that that WDT cord-010119-t1x9gknd 10950 14 provide provide VBP cord-010119-t1x9gknd 10950 15 harmonization harmonization NN cord-010119-t1x9gknd 10950 16 of of IN cord-010119-t1x9gknd 10950 17 dialogue dialogue NN cord-010119-t1x9gknd 10950 18 logistics logistic NNS cord-010119-t1x9gknd 10950 19 : : : cord-010119-t1x9gknd 10950 20 administrator administrator NN cord-010119-t1x9gknd 10950 21 -clinician -clinician NNP cord-010119-t1x9gknd 10950 22 -transfusiologist -transfusiologist NN cord-010119-t1x9gknd 10950 23 . . . cord-010119-t1x9gknd 10951 1 Study Study NNP cord-010119-t1x9gknd 10951 2 Design Design NNP cord-010119-t1x9gknd 10951 3 / / SYM cord-010119-t1x9gknd 10951 4 Method method NN cord-010119-t1x9gknd 10951 5 : : : cord-010119-t1x9gknd 10952 1 At at IN cord-010119-t1x9gknd 10952 2 the the DT cord-010119-t1x9gknd 10952 3 Medical Medical NNP cord-010119-t1x9gknd 10952 4 Simulation Simulation NNP cord-010119-t1x9gknd 10952 5 Centre Centre NNP cord-010119-t1x9gknd 10952 6 of of IN cord-010119-t1x9gknd 10952 7 hospital hospital NN cord-010119-t1x9gknd 10952 8 there there EX cord-010119-t1x9gknd 10952 9 has have VBZ cord-010119-t1x9gknd 10952 10 been be VBN cord-010119-t1x9gknd 10952 11 a a DT cord-010119-t1x9gknd 10952 12 unique unique JJ cord-010119-t1x9gknd 10952 13 opportunity opportunity NN cord-010119-t1x9gknd 10952 14 to to TO cord-010119-t1x9gknd 10952 15 launch launch VB cord-010119-t1x9gknd 10952 16 an an DT cord-010119-t1x9gknd 10952 17 educational educational JJ cord-010119-t1x9gknd 10952 18 program program NN cord-010119-t1x9gknd 10952 19 for for IN cord-010119-t1x9gknd 10952 20 the the DT cord-010119-t1x9gknd 10952 21 medical medical JJ cord-010119-t1x9gknd 10952 22 specialists specialist NNS cord-010119-t1x9gknd 10952 23 practicing practice VBG cord-010119-t1x9gknd 10952 24 blood blood NN cord-010119-t1x9gknd 10952 25 components component NNS cord-010119-t1x9gknd 10952 26 transfusion transfusion NN cord-010119-t1x9gknd 10952 27 . . . cord-010119-t1x9gknd 10953 1 The the DT cord-010119-t1x9gknd 10953 2 main main JJ cord-010119-t1x9gknd 10953 3 innovative innovative JJ cord-010119-t1x9gknd 10953 4 features feature NNS cord-010119-t1x9gknd 10953 5 of of IN cord-010119-t1x9gknd 10953 6 the the DT cord-010119-t1x9gknd 10953 7 training training NN cord-010119-t1x9gknd 10953 8 course course NN cord-010119-t1x9gknd 10953 9 are be VBP cord-010119-t1x9gknd 10953 10 an an DT cord-010119-t1x9gknd 10953 11 interdisciplinary interdisciplinary JJ cord-010119-t1x9gknd 10953 12 approach approach NN cord-010119-t1x9gknd 10953 13 , , , cord-010119-t1x9gknd 10953 14 intensive intensive JJ cord-010119-t1x9gknd 10953 15 learning learning NN cord-010119-t1x9gknd 10953 16 performance performance NN cord-010119-t1x9gknd 10953 17 , , , cord-010119-t1x9gknd 10953 18 comprehensiveness comprehensiveness NN cord-010119-t1x9gknd 10953 19 of of IN cord-010119-t1x9gknd 10953 20 learning learn VBG cord-010119-t1x9gknd 10953 21 methods method NNS cord-010119-t1x9gknd 10953 22 . . . cord-010119-t1x9gknd 10954 1 During during IN cord-010119-t1x9gknd 10954 2 2 2 CD cord-010119-t1x9gknd 10954 3 days day NNS cord-010119-t1x9gknd 10954 4 ( ( -LRB- cord-010119-t1x9gknd 10954 5 18 18 CD cord-010119-t1x9gknd 10954 6 academic academic JJ cord-010119-t1x9gknd 10954 7 hours hour NNS cord-010119-t1x9gknd 10954 8 ) ) -RRB- cord-010119-t1x9gknd 10954 9 the the DT cord-010119-t1x9gknd 10954 10 trainees trainee NNS cord-010119-t1x9gknd 10954 11 can can MD cord-010119-t1x9gknd 10954 12 attend attend VB cord-010119-t1x9gknd 10954 13 6 6 CD cord-010119-t1x9gknd 10954 14 lectures lecture NNS cord-010119-t1x9gknd 10954 15 , , , cord-010119-t1x9gknd 10954 16 discuss discuss VB cord-010119-t1x9gknd 10954 17 the the DT cord-010119-t1x9gknd 10954 18 methodical methodical JJ cord-010119-t1x9gknd 10954 19 materials material NNS cord-010119-t1x9gknd 10954 20 , , , cord-010119-t1x9gknd 10954 21 participate participate VBP cord-010119-t1x9gknd 10954 22 in in IN cord-010119-t1x9gknd 10954 23 3 3 CD cord-010119-t1x9gknd 10954 24 seminars seminar NNS cord-010119-t1x9gknd 10954 25 , , , cord-010119-t1x9gknd 10954 26 2 2 CD cord-010119-t1x9gknd 10954 27 interactive interactive JJ cord-010119-t1x9gknd 10954 28 clinical clinical JJ cord-010119-t1x9gknd 10954 29 discussions discussion NNS cord-010119-t1x9gknd 10954 30 , , , cord-010119-t1x9gknd 10954 31 a a DT cord-010119-t1x9gknd 10954 32 Master Master NNP cord-010119-t1x9gknd 10954 33 Class Class NNP cord-010119-t1x9gknd 10954 34 and and CC cord-010119-t1x9gknd 10954 35 a a DT cord-010119-t1x9gknd 10954 36 game game NN cord-010119-t1x9gknd 10954 37 that that WDT cord-010119-t1x9gknd 10954 38 presents present VBZ cord-010119-t1x9gknd 10954 39 the the DT cord-010119-t1x9gknd 10954 40 modelling modelling NN cord-010119-t1x9gknd 10954 41 of of IN cord-010119-t1x9gknd 10954 42 working work VBG cord-010119-t1x9gknd 10954 43 processes process NNS cord-010119-t1x9gknd 10954 44 . . . cord-010119-t1x9gknd 10955 1 Since since IN cord-010119-t1x9gknd 10955 2 initiating initiate VBG cord-010119-t1x9gknd 10955 3 the the DT cord-010119-t1x9gknd 10955 4 project project NN cord-010119-t1x9gknd 10955 5 in in IN cord-010119-t1x9gknd 10955 6 June June NNP cord-010119-t1x9gknd 10955 7 , , , cord-010119-t1x9gknd 10955 8 2016 2016 CD cord-010119-t1x9gknd 10955 9 with with IN cord-010119-t1x9gknd 10955 10 the the DT cord-010119-t1x9gknd 10955 11 group group NN cord-010119-t1x9gknd 10955 12 capacity capacity NN cord-010119-t1x9gknd 10955 13 220A 220a CD cord-010119-t1x9gknd 10955 14 TRANSFUSION transfusion NN cord-010119-t1x9gknd 10955 15 2017 2017 CD cord-010119-t1x9gknd 10955 16 Vol Vol NNP cord-010119-t1x9gknd 10955 17 . . . cord-010119-t1x9gknd 10956 1 57 57 CD cord-010119-t1x9gknd 10956 2 Supplement Supplement NNP cord-010119-t1x9gknd 10956 3 S3 S3 NNP cord-010119-t1x9gknd 10956 4 of of IN cord-010119-t1x9gknd 10956 5 up up IN cord-010119-t1x9gknd 10956 6 to to TO cord-010119-t1x9gknd 10956 7 35 35 CD cord-010119-t1x9gknd 10956 8 people people NNS cord-010119-t1x9gknd 10956 9 the the DT cord-010119-t1x9gknd 10956 10 number number NN cord-010119-t1x9gknd 10956 11 of of IN cord-010119-t1x9gknd 10956 12 medical medical JJ cord-010119-t1x9gknd 10956 13 specialists specialist NNS cord-010119-t1x9gknd 10956 14 who who WP cord-010119-t1x9gknd 10956 15 have have VBP cord-010119-t1x9gknd 10956 16 attended attend VBN cord-010119-t1x9gknd 10956 17 the the DT cord-010119-t1x9gknd 10956 18 training training NN cord-010119-t1x9gknd 10956 19 is be VBZ cord-010119-t1x9gknd 10956 20 nearly nearly RB cord-010119-t1x9gknd 10956 21 450 450 CD cord-010119-t1x9gknd 10956 22 . . . cord-010119-t1x9gknd 10957 1 Results/ Results/ . cord-010119-t1x9gknd 10958 1 Finding finding NN cord-010119-t1x9gknd 10958 2 : : : cord-010119-t1x9gknd 10959 1 The the DT cord-010119-t1x9gknd 10959 2 medical medical JJ cord-010119-t1x9gknd 10959 3 competencies competency NNS cord-010119-t1x9gknd 10959 4 gained gain VBD cord-010119-t1x9gknd 10959 5 : : : cord-010119-t1x9gknd 10959 6 knowledge knowledge NN cord-010119-t1x9gknd 10959 7 of of IN cord-010119-t1x9gknd 10959 8 modern modern JJ cord-010119-t1x9gknd 10959 9 recommendations recommendation NNS cord-010119-t1x9gknd 10959 10 on on IN cord-010119-t1x9gknd 10959 11 the the DT cord-010119-t1x9gknd 10959 12 use use NN cord-010119-t1x9gknd 10959 13 of of IN cord-010119-t1x9gknd 10959 14 blood blood NN cord-010119-t1x9gknd 10959 15 components component NNS cord-010119-t1x9gknd 10959 16 the the DT cord-010119-t1x9gknd 10959 17 ability ability NN cord-010119-t1x9gknd 10959 18 to to TO cord-010119-t1x9gknd 10959 19 interpret interpret VB cord-010119-t1x9gknd 10959 20 all all DT cord-010119-t1x9gknd 10959 21 parameters parameter NNS cord-010119-t1x9gknd 10959 22 of of IN cord-010119-t1x9gknd 10959 23 the the DT cord-010119-t1x9gknd 10959 24 haemogram haemogram NNP cord-010119-t1x9gknd 10959 25 , , , cord-010119-t1x9gknd 10959 26 coagulogram coagulogram NNP cord-010119-t1x9gknd 10959 27 and and CC cord-010119-t1x9gknd 10959 28 tromboelastogram tromboelastogram VB cord-010119-t1x9gknd 10959 29 the the DT cord-010119-t1x9gknd 10959 30 ability ability NN cord-010119-t1x9gknd 10959 31 to to TO cord-010119-t1x9gknd 10959 32 unveil unveil VB cord-010119-t1x9gknd 10959 33 the the DT cord-010119-t1x9gknd 10959 34 indications indication NNS cord-010119-t1x9gknd 10959 35 and and CC cord-010119-t1x9gknd 10959 36 contraindications contraindication NNS cord-010119-t1x9gknd 10959 37 for for IN cord-010119-t1x9gknd 10959 38 urgent urgent JJ cord-010119-t1x9gknd 10959 39 and and CC cord-010119-t1x9gknd 10959 40 scheduled scheduled JJ cord-010119-t1x9gknd 10959 41 blood blood NN cord-010119-t1x9gknd 10959 42 component component NN cord-010119-t1x9gknd 10959 43 transfusion transfusion NN cord-010119-t1x9gknd 10959 44 personalization personalization NN cord-010119-t1x9gknd 10959 45 of of IN cord-010119-t1x9gknd 10959 46 the the DT cord-010119-t1x9gknd 10959 47 blood blood NN cord-010119-t1x9gknd 10959 48 transfusion transfusion NN cord-010119-t1x9gknd 10959 49 risks risk NNS cord-010119-t1x9gknd 10959 50 using use VBG cord-010119-t1x9gknd 10959 51 a a DT cord-010119-t1x9gknd 10959 52 personalized personalized JJ cord-010119-t1x9gknd 10959 53 approach approach NN cord-010119-t1x9gknd 10959 54 on on IN cord-010119-t1x9gknd 10959 55 selecting select VBG cord-010119-t1x9gknd 10959 56 the the DT cord-010119-t1x9gknd 10959 57 type type NN cord-010119-t1x9gknd 10959 58 and and CC cord-010119-t1x9gknd 10959 59 the the DT cord-010119-t1x9gknd 10959 60 dosing dosing NN cord-010119-t1x9gknd 10959 61 of of IN cord-010119-t1x9gknd 10959 62 transfusion transfusion NN cord-010119-t1x9gknd 10959 63 habitat habitat NN cord-010119-t1x9gknd 10959 64 predicting predict VBG cord-010119-t1x9gknd 10959 65 the the DT cord-010119-t1x9gknd 10959 66 efficacy efficacy NN cord-010119-t1x9gknd 10959 67 of of IN cord-010119-t1x9gknd 10959 68 transfusion transfusion NN cord-010119-t1x9gknd 10959 69 the the DT cord-010119-t1x9gknd 10959 70 correction correction NN cord-010119-t1x9gknd 10959 71 of of IN cord-010119-t1x9gknd 10959 72 anemia anemia NN cord-010119-t1x9gknd 10959 73 and and CC cord-010119-t1x9gknd 10959 74 hemostasis hemostasis NN cord-010119-t1x9gknd 10959 75 system system NN cord-010119-t1x9gknd 10959 76 malfunctions malfunction NNS cord-010119-t1x9gknd 10959 77 using use VBG cord-010119-t1x9gknd 10959 78 the the DT cord-010119-t1x9gknd 10959 79 medicinal medicinal JJ cord-010119-t1x9gknd 10959 80 treatment treatment NN cord-010119-t1x9gknd 10959 81 performing perform VBG cord-010119-t1x9gknd 10959 82 the the DT cord-010119-t1x9gknd 10959 83 macroscopic macroscopic JJ cord-010119-t1x9gknd 10959 84 assessment assessment NN cord-010119-t1x9gknd 10959 85 of of IN cord-010119-t1x9gknd 10959 86 blood blood NN cord-010119-t1x9gknd 10959 87 component component NN cord-010119-t1x9gknd 10959 88 before before IN cord-010119-t1x9gknd 10959 89 the the DT cord-010119-t1x9gknd 10959 90 transfusion transfusion NN cord-010119-t1x9gknd 10959 91 procedure procedure NN cord-010119-t1x9gknd 10959 92 performing perform VBG cord-010119-t1x9gknd 10959 93 the the DT cord-010119-t1x9gknd 10959 94 differentiated differentiated JJ cord-010119-t1x9gknd 10959 95 diagnostics diagnostic NNS cord-010119-t1x9gknd 10959 96 and and CC cord-010119-t1x9gknd 10959 97 ability ability NN cord-010119-t1x9gknd 10959 98 to to TO cord-010119-t1x9gknd 10959 99 prescribe prescribe VB cord-010119-t1x9gknd 10959 100 the the DT cord-010119-t1x9gknd 10959 101 adverse adverse JJ cord-010119-t1x9gknd 10959 102 effect effect NN cord-010119-t1x9gknd 10959 103 treatment treatment NN cord-010119-t1x9gknd 10959 104 ability ability NN cord-010119-t1x9gknd 10959 105 to to TO cord-010119-t1x9gknd 10959 106 carry carry VB cord-010119-t1x9gknd 10959 107 out out RP cord-010119-t1x9gknd 10959 108 the the DT cord-010119-t1x9gknd 10959 109 auditorial auditorial JJ cord-010119-t1x9gknd 10959 110 check check NN cord-010119-t1x9gknd 10959 111 of of IN cord-010119-t1x9gknd 10960 1 health health NN cord-010119-t1x9gknd 10960 2 cards card NNS cord-010119-t1x9gknd 10960 3 Conclusion Conclusion NNP cord-010119-t1x9gknd 10960 4 : : : cord-010119-t1x9gknd 10961 1 The the DT cord-010119-t1x9gknd 10961 2 launch launch NN cord-010119-t1x9gknd 10961 3 of of IN cord-010119-t1x9gknd 10961 4 the the DT cord-010119-t1x9gknd 10961 5 program program NN cord-010119-t1x9gknd 10961 6 " " `` cord-010119-t1x9gknd 10961 7 Guidance guidance NN cord-010119-t1x9gknd 10961 8 for for IN cord-010119-t1x9gknd 10961 9 safe safe JJ cord-010119-t1x9gknd 10961 10 and and CC cord-010119-t1x9gknd 10961 11 effective effective JJ cord-010119-t1x9gknd 10961 12 blood blood NN cord-010119-t1x9gknd 10961 13 use use NN cord-010119-t1x9gknd 10961 14 in in IN cord-010119-t1x9gknd 10961 15 adult adult NN cord-010119-t1x9gknd 10961 16 patients patient NNS cord-010119-t1x9gknd 10961 17 of of IN cord-010119-t1x9gknd 10961 18 multi multi JJ cord-010119-t1x9gknd 10961 19 - - JJ cord-010119-t1x9gknd 10961 20 field field JJ cord-010119-t1x9gknd 10961 21 hospitals hospital NNS cord-010119-t1x9gknd 10961 22 " " '' cord-010119-t1x9gknd 10961 23 is be VBZ cord-010119-t1x9gknd 10961 24 aimed aim VBN cord-010119-t1x9gknd 10961 25 to to TO cord-010119-t1x9gknd 10961 26 meet meet VB cord-010119-t1x9gknd 10961 27 the the DT cord-010119-t1x9gknd 10961 28 educational educational JJ cord-010119-t1x9gknd 10961 29 and and CC cord-010119-t1x9gknd 10961 30 professional professional JJ cord-010119-t1x9gknd 10961 31 needs need NNS cord-010119-t1x9gknd 10961 32 of of IN cord-010119-t1x9gknd 10961 33 medical medical JJ cord-010119-t1x9gknd 10961 34 specialists specialist NNS cord-010119-t1x9gknd 10961 35 , , , cord-010119-t1x9gknd 10961 36 develop develop VB cord-010119-t1x9gknd 10961 37 the the DT cord-010119-t1x9gknd 10961 38 algorithmic algorithmic JJ cord-010119-t1x9gknd 10961 39 thinking thinking NN cord-010119-t1x9gknd 10961 40 and and CC cord-010119-t1x9gknd 10961 41 a a DT cord-010119-t1x9gknd 10961 42 range range NN cord-010119-t1x9gknd 10961 43 of of IN cord-010119-t1x9gknd 10961 44 useful useful JJ cord-010119-t1x9gknd 10961 45 motivations motivation NNS cord-010119-t1x9gknd 10961 46 in in IN cord-010119-t1x9gknd 10961 47 case case NN cord-010119-t1x9gknd 10961 48 of of IN cord-010119-t1x9gknd 10961 49 Patient Patient NNP cord-010119-t1x9gknd 10961 50 Blood Blood NNP cord-010119-t1x9gknd 10961 51 Management Management NNP cord-010119-t1x9gknd 10961 52 and and CC cord-010119-t1x9gknd 10961 53 reach reach VB cord-010119-t1x9gknd 10961 54 the the DT cord-010119-t1x9gknd 10961 55 Compliance Compliance NNP cord-010119-t1x9gknd 10961 56 in in IN cord-010119-t1x9gknd 10961 57 practice practice NN cord-010119-t1x9gknd 10961 58 . . . cord-010119-t1x9gknd 10962 1 The the DT cord-010119-t1x9gknd 10962 2 Effect effect NN cord-010119-t1x9gknd 10962 3 of of IN cord-010119-t1x9gknd 10962 4 Emergent Emergent NNP cord-010119-t1x9gknd 10962 5 Situation Situation NNP cord-010119-t1x9gknd 10962 6 Drills Drills NNP cord-010119-t1x9gknd 10962 7 on on IN cord-010119-t1x9gknd 10962 8 Technologist Technologist NNP cord-010119-t1x9gknd 10962 9 Teamwork Teamwork NNP cord-010119-t1x9gknd 10962 10 and and CC cord-010119-t1x9gknd 10962 11 Comfort Comfort NNP cord-010119-t1x9gknd 10962 12 Levels Levels NNP cord-010119-t1x9gknd 10962 13 Abigail Abigail NNP cord-010119-t1x9gknd 10962 14 Neils Neils NNP cord-010119-t1x9gknd 10962 15 * * NFP cord-010119-t1x9gknd 10962 16 , , , cord-010119-t1x9gknd 10962 17 RaeAnne RaeAnne NNP cord-010119-t1x9gknd 10962 18 Stensgard Stensgard NNP cord-010119-t1x9gknd 10962 19 , , , cord-010119-t1x9gknd 10962 20 Rebecca Rebecca NNP cord-010119-t1x9gknd 10962 21 Wren Wren NNP cord-010119-t1x9gknd 10962 22 , , , cord-010119-t1x9gknd 10962 23 Elisabeth Elisabeth NNP cord-010119-t1x9gknd 10962 24 Greer Greer NNP cord-010119-t1x9gknd 10962 25 , , , cord-010119-t1x9gknd 10962 26 Amy Amy NNP cord-010119-t1x9gknd 10962 27 Mata Mata NNP cord-010119-t1x9gknd 10962 28 and and CC cord-010119-t1x9gknd 10962 29 Camille Camille NNP cord-010119-t1x9gknd 10962 30 van van NNP cord-010119-t1x9gknd 10962 31 Buskirk Buskirk NNP cord-010119-t1x9gknd 10962 32 . . . cord-010119-t1x9gknd 10963 1 Mayo Mayo NNP cord-010119-t1x9gknd 10963 2 Clinic Clinic NNP cord-010119-t1x9gknd 10963 3 Rochester Rochester NNP cord-010119-t1x9gknd 10963 4 Background Background NNP cord-010119-t1x9gknd 10963 5 / / SYM cord-010119-t1x9gknd 10963 6 Case Case NNP cord-010119-t1x9gknd 10963 7 Studies Studies NNPS cord-010119-t1x9gknd 10963 8 : : : cord-010119-t1x9gknd 10964 1 Teamwork teamwork NN cord-010119-t1x9gknd 10964 2 and and CC cord-010119-t1x9gknd 10964 3 composure composure NN cord-010119-t1x9gknd 10964 4 are be VBP cord-010119-t1x9gknd 10964 5 essential essential JJ cord-010119-t1x9gknd 10964 6 for for IN cord-010119-t1x9gknd 10964 7 technologists technologist NNS cord-010119-t1x9gknd 10964 8 when when WRB cord-010119-t1x9gknd 10964 9 dealing deal VBG cord-010119-t1x9gknd 10964 10 with with IN cord-010119-t1x9gknd 10964 11 emergent emergent JJ cord-010119-t1x9gknd 10964 12 situations situation NNS cord-010119-t1x9gknd 10964 13 in in IN cord-010119-t1x9gknd 10964 14 a a DT cord-010119-t1x9gknd 10964 15 large large JJ cord-010119-t1x9gknd 10964 16 hospitalbased hospitalbased JJ cord-010119-t1x9gknd 10964 17 blood blood NN cord-010119-t1x9gknd 10964 18 bank bank NN cord-010119-t1x9gknd 10964 19 where where WRB cord-010119-t1x9gknd 10964 20 multiple multiple JJ cord-010119-t1x9gknd 10964 21 situations situation NNS cord-010119-t1x9gknd 10964 22 can can MD cord-010119-t1x9gknd 10964 23 occur occur VB cord-010119-t1x9gknd 10964 24 simultaneously simultaneously RB cord-010119-t1x9gknd 10964 25 . . . cord-010119-t1x9gknd 10965 1 In in IN cord-010119-t1x9gknd 10965 2 an an DT cord-010119-t1x9gknd 10965 3 effort effort NN cord-010119-t1x9gknd 10965 4 to to TO cord-010119-t1x9gknd 10965 5 reduce reduce VB cord-010119-t1x9gknd 10965 6 errors error NNS cord-010119-t1x9gknd 10965 7 and and CC cord-010119-t1x9gknd 10965 8 improve improve VB cord-010119-t1x9gknd 10965 9 emergency emergency NN cord-010119-t1x9gknd 10965 10 response response NN cord-010119-t1x9gknd 10965 11 , , , cord-010119-t1x9gknd 10965 12 a a DT cord-010119-t1x9gknd 10965 13 group group NN cord-010119-t1x9gknd 10965 14 was be VBD cord-010119-t1x9gknd 10965 15 formed form VBN cord-010119-t1x9gknd 10965 16 to to TO cord-010119-t1x9gknd 10965 17 evaluate evaluate VB cord-010119-t1x9gknd 10965 18 the the DT cord-010119-t1x9gknd 10965 19 effectiveness effectiveness NN cord-010119-t1x9gknd 10965 20 of of IN cord-010119-t1x9gknd 10965 21 emergency emergency NN cord-010119-t1x9gknd 10965 22 situation situation NN cord-010119-t1x9gknd 10965 23 drills drill VBZ cord-010119-t1x9gknd 10965 24 ( ( -LRB- cord-010119-t1x9gknd 10965 25 ESD ESD NNP cord-010119-t1x9gknd 10965 26 ) ) -RRB- cord-010119-t1x9gknd 10965 27 . . . cord-010119-t1x9gknd 10966 1 The the DT cord-010119-t1x9gknd 10966 2 ESD ESD NNP cord-010119-t1x9gknd 10966 3 were be VBD cord-010119-t1x9gknd 10966 4 based base VBN cord-010119-t1x9gknd 10966 5 on on IN cord-010119-t1x9gknd 10966 6 common common JJ cord-010119-t1x9gknd 10966 7 emergent emergent JJ cord-010119-t1x9gknd 10966 8 situations situation NNS cord-010119-t1x9gknd 10966 9 encountered encounter VBN cord-010119-t1x9gknd 10966 10 in in IN cord-010119-t1x9gknd 10966 11 the the DT cord-010119-t1x9gknd 10966 12 lab lab NN cord-010119-t1x9gknd 10966 13 and and CC cord-010119-t1x9gknd 10966 14 were be VBD cord-010119-t1x9gknd 10966 15 run run VBN cord-010119-t1x9gknd 10966 16 once once RB cord-010119-t1x9gknd 10966 17 per per IN cord-010119-t1x9gknd 10966 18 month month NN cord-010119-t1x9gknd 10966 19 per per IN cord-010119-t1x9gknd 10966 20 shift shift NN cord-010119-t1x9gknd 10966 21 . . . cord-010119-t1x9gknd 10967 1 The the DT cord-010119-t1x9gknd 10967 2 main main JJ cord-010119-t1x9gknd 10967 3 goal goal NN cord-010119-t1x9gknd 10967 4 of of IN cord-010119-t1x9gknd 10967 5 ESD ESD NNP cord-010119-t1x9gknd 10967 6 was be VBD cord-010119-t1x9gknd 10967 7 to to TO cord-010119-t1x9gknd 10967 8 improve improve VB cord-010119-t1x9gknd 10967 9 teamwork teamwork NN cord-010119-t1x9gknd 10967 10 and and CC cord-010119-t1x9gknd 10967 11 comfort comfort NN cord-010119-t1x9gknd 10967 12 level level NN cord-010119-t1x9gknd 10967 13 during during IN cord-010119-t1x9gknd 10967 14 real real JJ cord-010119-t1x9gknd 10967 15 emergent emergent JJ cord-010119-t1x9gknd 10967 16 situations situation NNS cord-010119-t1x9gknd 10967 17 ; ; : cord-010119-t1x9gknd 10967 18 therefore therefore RB cord-010119-t1x9gknd 10967 19 reducing reduce VBG cord-010119-t1x9gknd 10967 20 the the DT cord-010119-t1x9gknd 10967 21 amount amount NN cord-010119-t1x9gknd 10967 22 of of IN cord-010119-t1x9gknd 10967 23 unplanned unplanned JJ cord-010119-t1x9gknd 10967 24 standard standard JJ cord-010119-t1x9gknd 10967 25 operating operating NN cord-010119-t1x9gknd 10967 26 procedure procedure NN cord-010119-t1x9gknd 10967 27 ( ( -LRB- cord-010119-t1x9gknd 10967 28 SOP SOP NNP cord-010119-t1x9gknd 10967 29 ) ) -RRB- cord-010119-t1x9gknd 10967 30 deviations deviation NNS cord-010119-t1x9gknd 10967 31 . . . cord-010119-t1x9gknd 10968 1 Study Study NNP cord-010119-t1x9gknd 10968 2 Design Design NNP cord-010119-t1x9gknd 10968 3 / / SYM cord-010119-t1x9gknd 10968 4 Method method NN cord-010119-t1x9gknd 10968 5 : : : cord-010119-t1x9gknd 10969 1 Prior prior RB cord-010119-t1x9gknd 10969 2 to to IN cord-010119-t1x9gknd 10969 3 ESD ESD NNP cord-010119-t1x9gknd 10969 4 implementation implementation NN cord-010119-t1x9gknd 10969 5 , , , cord-010119-t1x9gknd 10969 6 a a DT cord-010119-t1x9gknd 10969 7 survey survey NN cord-010119-t1x9gknd 10969 8 was be VBD cord-010119-t1x9gknd 10969 9 sent send VBN cord-010119-t1x9gknd 10969 10 to to IN cord-010119-t1x9gknd 10969 11 all all DT cord-010119-t1x9gknd 10969 12 technologists technologist NNS cord-010119-t1x9gknd 10969 13 to to TO cord-010119-t1x9gknd 10969 14 determine determine VB cord-010119-t1x9gknd 10969 15 baseline baseline JJ cord-010119-t1x9gknd 10969 16 comfort comfort NN cord-010119-t1x9gknd 10969 17 levels level NNS cord-010119-t1x9gknd 10969 18 associated associate VBN cord-010119-t1x9gknd 10969 19 with with IN cord-010119-t1x9gknd 10969 20 various various JJ cord-010119-t1x9gknd 10969 21 emergent emergent JJ cord-010119-t1x9gknd 10969 22 situations situation NNS cord-010119-t1x9gknd 10969 23 . . . cord-010119-t1x9gknd 10970 1 One one CD cord-010119-t1x9gknd 10970 2 year year NN cord-010119-t1x9gknd 10970 3 post post NN cord-010119-t1x9gknd 10970 4 ESD ESD NNP cord-010119-t1x9gknd 10970 5 implementation implementation NN cord-010119-t1x9gknd 10971 1 the the DT cord-010119-t1x9gknd 10971 2 same same JJ cord-010119-t1x9gknd 10971 3 survey survey NN cord-010119-t1x9gknd 10971 4 was be VBD cord-010119-t1x9gknd 10971 5 sent send VBN cord-010119-t1x9gknd 10971 6 to to IN cord-010119-t1x9gknd 10971 7 all all DT cord-010119-t1x9gknd 10971 8 technologists technologist NNS cord-010119-t1x9gknd 10971 9 to to TO cord-010119-t1x9gknd 10971 10 reassess reassess VB cord-010119-t1x9gknd 10971 11 the the DT cord-010119-t1x9gknd 10971 12 comfort comfort NN cord-010119-t1x9gknd 10971 13 levels level NNS cord-010119-t1x9gknd 10971 14 for for IN cord-010119-t1x9gknd 10971 15 the the DT cord-010119-t1x9gknd 10971 16 same same JJ cord-010119-t1x9gknd 10971 17 situations situation NNS cord-010119-t1x9gknd 10971 18 . . . cord-010119-t1x9gknd 10972 1 The the DT cord-010119-t1x9gknd 10972 2 surveys survey NNS cord-010119-t1x9gknd 10972 3 asked ask VBD cord-010119-t1x9gknd 10972 4 employees employee NNS cord-010119-t1x9gknd 10972 5 to to TO cord-010119-t1x9gknd 10972 6 rate rate VB cord-010119-t1x9gknd 10972 7 satisfaction satisfaction NN cord-010119-t1x9gknd 10972 8 and and CC cord-010119-t1x9gknd 10972 9 comfort comfort NN cord-010119-t1x9gknd 10972 10 level level NN cord-010119-t1x9gknd 10972 11 on on IN cord-010119-t1x9gknd 10972 12 a a DT cord-010119-t1x9gknd 10972 13 grading grading NN cord-010119-t1x9gknd 10972 14 scale scale NN cord-010119-t1x9gknd 10972 15 of of IN cord-010119-t1x9gknd 10972 16 1 1 CD cord-010119-t1x9gknd 10972 17 - - SYM cord-010119-t1x9gknd 10972 18 100 100 CD cord-010119-t1x9gknd 10972 19 ; ; : cord-010119-t1x9gknd 10972 20 1 1 CD cord-010119-t1x9gknd 10972 21 being be VBG cord-010119-t1x9gknd 10972 22 least least RBS cord-010119-t1x9gknd 10972 23 satisfied satisfied JJ cord-010119-t1x9gknd 10972 24 / / SYM cord-010119-t1x9gknd 10972 25 comfortable comfortable JJ cord-010119-t1x9gknd 10972 26 and and CC cord-010119-t1x9gknd 10972 27 100 100 CD cord-010119-t1x9gknd 10972 28 being be VBG cord-010119-t1x9gknd 10972 29 most most RBS cord-010119-t1x9gknd 10972 30 satisfied satisfied JJ cord-010119-t1x9gknd 10972 31 / / SYM cord-010119-t1x9gknd 10972 32 comfortable comfortable JJ cord-010119-t1x9gknd 10972 33 . . . cord-010119-t1x9gknd 10973 1 The the DT cord-010119-t1x9gknd 10973 2 pre pre JJ cord-010119-t1x9gknd 10973 3 and and CC cord-010119-t1x9gknd 10973 4 post post JJ cord-010119-t1x9gknd 10973 5 survey survey NN cord-010119-t1x9gknd 10973 6 results result NNS cord-010119-t1x9gknd 10973 7 were be VBD cord-010119-t1x9gknd 10973 8 evaluated evaluate VBN cord-010119-t1x9gknd 10973 9 by by IN cord-010119-t1x9gknd 10973 10 calculating calculate VBG cord-010119-t1x9gknd 10973 11 lab lab NN cord-010119-t1x9gknd 10973 12 average average JJ cord-010119-t1x9gknd 10973 13 comfort comfort NN cord-010119-t1x9gknd 10973 14 levels level NNS cord-010119-t1x9gknd 10973 15 per per IN cord-010119-t1x9gknd 10973 16 situation situation NN cord-010119-t1x9gknd 10973 17 and and CC cord-010119-t1x9gknd 10973 18 survey survey NN cord-010119-t1x9gknd 10973 19 . . . cord-010119-t1x9gknd 10974 1 In in IN cord-010119-t1x9gknd 10974 2 addition addition NN cord-010119-t1x9gknd 10974 3 , , , cord-010119-t1x9gknd 10974 4 unplanned unplanned JJ cord-010119-t1x9gknd 10974 5 SOP sop NN cord-010119-t1x9gknd 10974 6 deviations deviation NNS cord-010119-t1x9gknd 10974 7 related relate VBN cord-010119-t1x9gknd 10974 8 to to IN cord-010119-t1x9gknd 10974 9 emergent emergent JJ cord-010119-t1x9gknd 10974 10 situations situation NNS cord-010119-t1x9gknd 10974 11 were be VBD cord-010119-t1x9gknd 10974 12 counted count VBN cord-010119-t1x9gknd 10974 13 for for IN cord-010119-t1x9gknd 10974 14 one one CD cord-010119-t1x9gknd 10974 15 year year NN cord-010119-t1x9gknd 10974 16 before before RB cord-010119-t1x9gknd 10974 17 and and CC cord-010119-t1x9gknd 10974 18 one one CD cord-010119-t1x9gknd 10974 19 year year NN cord-010119-t1x9gknd 10974 20 after after IN cord-010119-t1x9gknd 10974 21 ESD ESD NNP cord-010119-t1x9gknd 10974 22 implementation implementation NN cord-010119-t1x9gknd 10974 23 . . . cord-010119-t1x9gknd 10975 1 Results result NNS cord-010119-t1x9gknd 10975 2 / / SYM cord-010119-t1x9gknd 10975 3 Findings finding NNS cord-010119-t1x9gknd 10975 4 : : : cord-010119-t1x9gknd 10976 1 Out out IN cord-010119-t1x9gknd 10976 2 of of IN cord-010119-t1x9gknd 10976 3 35 35 CD cord-010119-t1x9gknd 10976 4 total total JJ cord-010119-t1x9gknd 10976 5 technologists technologist NNS cord-010119-t1x9gknd 10976 6 , , , cord-010119-t1x9gknd 10976 7 31 31 CD cord-010119-t1x9gknd 10976 8 technologists technologist NNS cord-010119-t1x9gknd 10976 9 took take VBD cord-010119-t1x9gknd 10976 10 the the DT cord-010119-t1x9gknd 10976 11 pre pre JJ cord-010119-t1x9gknd 10976 12 ESD ESD NNP cord-010119-t1x9gknd 10976 13 survey survey NN cord-010119-t1x9gknd 10976 14 and and CC cord-010119-t1x9gknd 10976 15 25 25 CD cord-010119-t1x9gknd 10976 16 technologists technologist NNS cord-010119-t1x9gknd 10976 17 took take VBD cord-010119-t1x9gknd 10976 18 the the DT cord-010119-t1x9gknd 10976 19 one one CD cord-010119-t1x9gknd 10976 20 year year NN cord-010119-t1x9gknd 10976 21 post post NN cord-010119-t1x9gknd 10976 22 ESD ESD NNP cord-010119-t1x9gknd 10976 23 implementation implementation NN cord-010119-t1x9gknd 10976 24 survey survey NN cord-010119-t1x9gknd 10976 25 . . . cord-010119-t1x9gknd 10977 1 Table table NN cord-010119-t1x9gknd 10977 2 1 1 CD cord-010119-t1x9gknd 10977 3 shows show VBZ cord-010119-t1x9gknd 10977 4 the the DT cord-010119-t1x9gknd 10977 5 lab lab NN cord-010119-t1x9gknd 10977 6 averages average NNS cord-010119-t1x9gknd 10977 7 from from IN cord-010119-t1x9gknd 10977 8 the the DT cord-010119-t1x9gknd 10977 9 pre pre JJ cord-010119-t1x9gknd 10977 10 and and CC cord-010119-t1x9gknd 10977 11 post post VB cord-010119-t1x9gknd 10977 12 surveys survey NNS cord-010119-t1x9gknd 10977 13 as as RB cord-010119-t1x9gknd 10977 14 well well RB cord-010119-t1x9gknd 10977 15 as as IN cord-010119-t1x9gknd 10977 16 the the DT cord-010119-t1x9gknd 10977 17 percent percent NN cord-010119-t1x9gknd 10977 18 difference difference NN cord-010119-t1x9gknd 10977 19 . . . cord-010119-t1x9gknd 10978 1 Out out IN cord-010119-t1x9gknd 10978 2 of of IN cord-010119-t1x9gknd 10978 3 the the DT cord-010119-t1x9gknd 10978 4 employees employee NNS cord-010119-t1x9gknd 10978 5 who who WP cord-010119-t1x9gknd 10978 6 responded respond VBD cord-010119-t1x9gknd 10978 7 to to IN cord-010119-t1x9gknd 10978 8 the the DT cord-010119-t1x9gknd 10978 9 post post NN cord-010119-t1x9gknd 10978 10 survey survey NN cord-010119-t1x9gknd 10978 11 , , , cord-010119-t1x9gknd 10978 12 19 19 CD cord-010119-t1x9gknd 10978 13 ( ( -LRB- cord-010119-t1x9gknd 10978 14 76.0 76.0 CD cord-010119-t1x9gknd 10978 15 % % NN cord-010119-t1x9gknd 10978 16 ) ) -RRB- cord-010119-t1x9gknd 10978 17 answered answer VBD cord-010119-t1x9gknd 10978 18 " " `` cord-010119-t1x9gknd 10978 19 true true JJ cord-010119-t1x9gknd 10978 20 " " '' cord-010119-t1x9gknd 10978 21 to to IN cord-010119-t1x9gknd 10978 22 the the DT cord-010119-t1x9gknd 10978 23 statement statement NN cord-010119-t1x9gknd 10978 24 " " `` cord-010119-t1x9gknd 10978 25 ESD ESD NNP cord-010119-t1x9gknd 10978 26 have have VBP cord-010119-t1x9gknd 10978 27 improved improve VBN cord-010119-t1x9gknd 10978 28 my -PRON- PRP$ cord-010119-t1x9gknd 10978 29 comfort comfort NN cord-010119-t1x9gknd 10978 30 level level NN cord-010119-t1x9gknd 10978 31 with with IN cord-010119-t1x9gknd 10978 32 emergent emergent JJ cord-010119-t1x9gknd 10978 33 situations situation NNS cord-010119-t1x9gknd 10978 34 . . . cord-010119-t1x9gknd 10978 35 " " '' cord-010119-t1x9gknd 10979 1 In in IN cord-010119-t1x9gknd 10979 2 the the DT cord-010119-t1x9gknd 10979 3 year year NN cord-010119-t1x9gknd 10979 4 prior prior RB cord-010119-t1x9gknd 10979 5 to to IN cord-010119-t1x9gknd 10979 6 ESD ESD NNP cord-010119-t1x9gknd 10979 7 implementation implementation NN cord-010119-t1x9gknd 10979 8 there there EX cord-010119-t1x9gknd 10979 9 were be VBD cord-010119-t1x9gknd 10979 10 14 14 CD cord-010119-t1x9gknd 10979 11 unplanned unplanned JJ cord-010119-t1x9gknd 10979 12 SOP sop NN cord-010119-t1x9gknd 10979 13 deviations deviation NNS cord-010119-t1x9gknd 10979 14 ; ; : cord-010119-t1x9gknd 10979 15 in in IN cord-010119-t1x9gknd 10979 16 the the DT cord-010119-t1x9gknd 10979 17 year year NN cord-010119-t1x9gknd 10979 18 after after IN cord-010119-t1x9gknd 10979 19 ESD ESD NNP cord-010119-t1x9gknd 10979 20 implementation implementation NN cord-010119-t1x9gknd 10979 21 there there EX cord-010119-t1x9gknd 10979 22 were be VBD cord-010119-t1x9gknd 10979 23 only only RB cord-010119-t1x9gknd 10979 24 5 5 CD cord-010119-t1x9gknd 10979 25 deviations deviation NNS cord-010119-t1x9gknd 10979 26 . . . cord-010119-t1x9gknd 10980 1 Conclusion conclusion NN cord-010119-t1x9gknd 10980 2 : : : cord-010119-t1x9gknd 10981 1 All all DT cord-010119-t1x9gknd 10981 2 but but IN cord-010119-t1x9gknd 10981 3 one one CD cord-010119-t1x9gknd 10981 4 area area NN cord-010119-t1x9gknd 10981 5 increased increase VBD cord-010119-t1x9gknd 10981 6 in in IN cord-010119-t1x9gknd 10981 7 comfort comfort NN cord-010119-t1x9gknd 10981 8 level level NN cord-010119-t1x9gknd 10981 9 post post NN cord-010119-t1x9gknd 10981 10 ESD ESD NNP cord-010119-t1x9gknd 10981 11 implementation implementation NN cord-010119-t1x9gknd 10981 12 . . . cord-010119-t1x9gknd 10982 1 Also also RB cord-010119-t1x9gknd 10982 2 most most JJS cord-010119-t1x9gknd 10982 3 technologists technologist NNS cord-010119-t1x9gknd 10982 4 agreed agree VBD cord-010119-t1x9gknd 10982 5 that that IN cord-010119-t1x9gknd 10982 6 the the DT cord-010119-t1x9gknd 10982 7 ESD ESD NNP cord-010119-t1x9gknd 10982 8 helped help VBD cord-010119-t1x9gknd 10982 9 improve improve VB cord-010119-t1x9gknd 10982 10 their -PRON- PRP$ cord-010119-t1x9gknd 10982 11 overall overall JJ cord-010119-t1x9gknd 10982 12 comfort comfort NN cord-010119-t1x9gknd 10982 13 level level NN cord-010119-t1x9gknd 10982 14 with with IN cord-010119-t1x9gknd 10982 15 emergent emergent JJ cord-010119-t1x9gknd 10982 16 situations situation NNS cord-010119-t1x9gknd 10982 17 . . . cord-010119-t1x9gknd 10983 1 The the DT cord-010119-t1x9gknd 10983 2 goal goal NN cord-010119-t1x9gknd 10983 3 of of IN cord-010119-t1x9gknd 10983 4 implementing implement VBG cord-010119-t1x9gknd 10983 5 ESD ESD NNP cord-010119-t1x9gknd 10983 6 has have VBZ cord-010119-t1x9gknd 10983 7 been be VBN cord-010119-t1x9gknd 10983 8 met meet VBN cord-010119-t1x9gknd 10983 9 based base VBN cord-010119-t1x9gknd 10983 10 on on IN cord-010119-t1x9gknd 10983 11 the the DT cord-010119-t1x9gknd 10983 12 unplanned unplanned JJ cord-010119-t1x9gknd 10983 13 SOP sop NN cord-010119-t1x9gknd 10983 14 deviation deviation NN cord-010119-t1x9gknd 10983 15 decrease decrease NN cord-010119-t1x9gknd 10983 16 and and CC cord-010119-t1x9gknd 10983 17 technologist technologist NN cord-010119-t1x9gknd 10983 18 satisfaction satisfaction NN cord-010119-t1x9gknd 10983 19 increase increase NN cord-010119-t1x9gknd 10983 20 ; ; : cord-010119-t1x9gknd 10983 21 therefore therefore RB cord-010119-t1x9gknd 10983 22 ESD ESD NNP cord-010119-t1x9gknd 10983 23 were be VBD cord-010119-t1x9gknd 10983 24 deemed deem VBN cord-010119-t1x9gknd 10983 25 effective effective JJ cord-010119-t1x9gknd 10983 26 . . . cord-010119-t1x9gknd 10984 1 Monthly Monthly NNP cord-010119-t1x9gknd 10984 2 ESD ESD NNP cord-010119-t1x9gknd 10984 3 will will MD cord-010119-t1x9gknd 10984 4 continue continue VB cord-010119-t1x9gknd 10984 5 to to TO cord-010119-t1x9gknd 10984 6 be be VB cord-010119-t1x9gknd 10984 7 run run VBN cord-010119-t1x9gknd 10984 8 with with IN cord-010119-t1x9gknd 10984 9 the the DT cord-010119-t1x9gknd 10984 10 hope hope NN cord-010119-t1x9gknd 10984 11 of of IN cord-010119-t1x9gknd 10984 12 continual continual JJ cord-010119-t1x9gknd 10984 13 improvement improvement NN cord-010119-t1x9gknd 10984 14 in in IN cord-010119-t1x9gknd 10984 15 teamwork teamwork NN cord-010119-t1x9gknd 10984 16 , , , cord-010119-t1x9gknd 10984 17 comfort comfort NN cord-010119-t1x9gknd 10984 18 levels level NNS cord-010119-t1x9gknd 10984 19 and and CC cord-010119-t1x9gknd 10984 20 deviation deviation NN cord-010119-t1x9gknd 10984 21 levels level NNS cord-010119-t1x9gknd 10984 22 . . . cord-010119-t1x9gknd 10985 1 Therapeutic therapeutic JJ cord-010119-t1x9gknd 10985 2 Background Background NNP cord-010119-t1x9gknd 10985 3 / / SYM cord-010119-t1x9gknd 10985 4 Case Case NNP cord-010119-t1x9gknd 10985 5 Studies Studies NNPS cord-010119-t1x9gknd 10985 6 : : : cord-010119-t1x9gknd 10985 7 Category category NN cord-010119-t1x9gknd 10986 1 I -PRON- PRP cord-010119-t1x9gknd 10986 2 indications indication NNS cord-010119-t1x9gknd 10986 3 for for IN cord-010119-t1x9gknd 10986 4 red red JJ cord-010119-t1x9gknd 10986 5 blood blood NN cord-010119-t1x9gknd 10986 6 cell cell NN cord-010119-t1x9gknd 10986 7 exchange exchange NN cord-010119-t1x9gknd 10986 8 ( ( -LRB- cord-010119-t1x9gknd 10986 9 RBC RBC NNP cord-010119-t1x9gknd 10986 10 exchange exchange NN cord-010119-t1x9gknd 10986 11 ) ) -RRB- cord-010119-t1x9gknd 10986 12 in in IN cord-010119-t1x9gknd 10986 13 children child NNS cord-010119-t1x9gknd 10986 14 with with IN cord-010119-t1x9gknd 10986 15 sickle sickle NN cord-010119-t1x9gknd 10986 16 cell cell NN cord-010119-t1x9gknd 10986 17 disease disease NN cord-010119-t1x9gknd 10986 18 include include VBP cord-010119-t1x9gknd 10986 19 following follow VBG cord-010119-t1x9gknd 10986 20 acute acute JJ cord-010119-t1x9gknd 10986 21 stroke stroke NN cord-010119-t1x9gknd 10986 22 and and CC cord-010119-t1x9gknd 10986 23 for for IN cord-010119-t1x9gknd 10986 24 stroke stroke NN cord-010119-t1x9gknd 10986 25 prophylaxis prophylaxis NN cord-010119-t1x9gknd 10986 26 , , , cord-010119-t1x9gknd 10986 27 as as RB cord-010119-t1x9gknd 10986 28 well well RB cord-010119-t1x9gknd 10986 29 as as IN cord-010119-t1x9gknd 10986 30 for for IN cord-010119-t1x9gknd 10986 31 iron iron NN cord-010119-t1x9gknd 10986 32 overload overload NN cord-010119-t1x9gknd 10986 33 prevention prevention NN cord-010119-t1x9gknd 10986 34 . . . cord-010119-t1x9gknd 10987 1 As as IN cord-010119-t1x9gknd 10987 2 described describe VBN cord-010119-t1x9gknd 10987 3 in in IN cord-010119-t1x9gknd 10987 4 the the DT cord-010119-t1x9gknd 10987 5 first first JJ cord-010119-t1x9gknd 10987 6 installment installment NN cord-010119-t1x9gknd 10987 7 of of IN cord-010119-t1x9gknd 10987 8 this this DT cord-010119-t1x9gknd 10987 9 series series NN cord-010119-t1x9gknd 10987 10 about about IN cord-010119-t1x9gknd 10987 11 therapeutic therapeutic JJ cord-010119-t1x9gknd 10987 12 plasma plasma NN cord-010119-t1x9gknd 10987 13 exchange exchange NN cord-010119-t1x9gknd 10987 14 ( ( -LRB- cord-010119-t1x9gknd 10987 15 TPE TPE NNP cord-010119-t1x9gknd 10987 16 ) ) -RRB- cord-010119-t1x9gknd 10987 17 , , , cord-010119-t1x9gknd 10987 18 the the DT cord-010119-t1x9gknd 10987 19 challenges challenge NNS cord-010119-t1x9gknd 10987 20 of of IN cord-010119-t1x9gknd 10987 21 access access NN cord-010119-t1x9gknd 10987 22 , , , cord-010119-t1x9gknd 10987 23 volume volume NN cord-010119-t1x9gknd 10987 24 management management NN cord-010119-t1x9gknd 10987 25 , , , cord-010119-t1x9gknd 10987 26 and and CC cord-010119-t1x9gknd 10987 27 instrumentation instrumentation NN cord-010119-t1x9gknd 10987 28 persist persist VBP cord-010119-t1x9gknd 10987 29 , , , cord-010119-t1x9gknd 10987 30 as as IN cord-010119-t1x9gknd 10987 31 along along IN cord-010119-t1x9gknd 10987 32 with with IN cord-010119-t1x9gknd 10987 33 the the DT cord-010119-t1x9gknd 10987 34 need need NN cord-010119-t1x9gknd 10987 35 to to TO cord-010119-t1x9gknd 10987 36 address address VB cord-010119-t1x9gknd 10987 37 the the DT cord-010119-t1x9gknd 10987 38 psychological psychological JJ cord-010119-t1x9gknd 10987 39 and and CC cord-010119-t1x9gknd 10987 40 emotional emotional JJ cord-010119-t1x9gknd 10987 41 well well NN cord-010119-t1x9gknd 10987 42 being being NN cord-010119-t1x9gknd 10987 43 of of IN cord-010119-t1x9gknd 10987 44 this this DT cord-010119-t1x9gknd 10987 45 population population NN cord-010119-t1x9gknd 10987 46 . . . cord-010119-t1x9gknd 10988 1 RBC RBC NNP cord-010119-t1x9gknd 10988 2 exchange exchange NN cord-010119-t1x9gknd 10988 3 is be VBZ cord-010119-t1x9gknd 10988 4 a a DT cord-010119-t1x9gknd 10988 5 complicated complicated JJ cord-010119-t1x9gknd 10988 6 procedure procedure NN cord-010119-t1x9gknd 10988 7 to to TO cord-010119-t1x9gknd 10988 8 explain explain VB cord-010119-t1x9gknd 10988 9 to to IN cord-010119-t1x9gknd 10988 10 adults adult NNS cord-010119-t1x9gknd 10988 11 and and CC cord-010119-t1x9gknd 10988 12 becomes become VBZ cord-010119-t1x9gknd 10988 13 an an DT cord-010119-t1x9gknd 10988 14 even even RB cord-010119-t1x9gknd 10988 15 more more RBR cord-010119-t1x9gknd 10988 16 intimidating intimidating JJ cord-010119-t1x9gknd 10988 17 task task NN cord-010119-t1x9gknd 10988 18 when when WRB cord-010119-t1x9gknd 10988 19 translating translate VBG cord-010119-t1x9gknd 10988 20 into into IN cord-010119-t1x9gknd 10988 21 the the DT cord-010119-t1x9gknd 10988 22 language language NN cord-010119-t1x9gknd 10988 23 of of IN cord-010119-t1x9gknd 10988 24 childhood childhood NN cord-010119-t1x9gknd 10988 25 . . . cord-010119-t1x9gknd 10989 1 Nevertheless nevertheless RB cord-010119-t1x9gknd 10989 2 , , , cord-010119-t1x9gknd 10989 3 pre pre JJ cord-010119-t1x9gknd 10989 4 - - JJ cord-010119-t1x9gknd 10989 5 treatment treatment JJ cord-010119-t1x9gknd 10989 6 education education NN cord-010119-t1x9gknd 10989 7 is be VBZ cord-010119-t1x9gknd 10989 8 shown show VBN cord-010119-t1x9gknd 10989 9 to to TO cord-010119-t1x9gknd 10989 10 decrease decrease VB cord-010119-t1x9gknd 10989 11 the the DT cord-010119-t1x9gknd 10989 12 anxiety anxiety NN cord-010119-t1x9gknd 10989 13 associated associate VBN cord-010119-t1x9gknd 10989 14 with with IN cord-010119-t1x9gknd 10989 15 medical medical JJ cord-010119-t1x9gknd 10989 16 care care NN cord-010119-t1x9gknd 10989 17 . . . cord-010119-t1x9gknd 10990 1 Providing provide VBG cord-010119-t1x9gknd 10990 2 age age NN cord-010119-t1x9gknd 10990 3 appropriate appropriate JJ cord-010119-t1x9gknd 10990 4 specific specific JJ cord-010119-t1x9gknd 10990 5 treatment treatment NN cord-010119-t1x9gknd 10990 6 information information NN cord-010119-t1x9gknd 10990 7 to to IN cord-010119-t1x9gknd 10990 8 pediatric pediatric JJ cord-010119-t1x9gknd 10990 9 patients patient NNS cord-010119-t1x9gknd 10990 10 decreases decrease VBZ cord-010119-t1x9gknd 10990 11 negative negative JJ cord-010119-t1x9gknd 10990 12 behaviors behavior NNS cord-010119-t1x9gknd 10990 13 , , , cord-010119-t1x9gknd 10990 14 reduces reduce VBZ cord-010119-t1x9gknd 10990 15 stress stress NN cord-010119-t1x9gknd 10990 16 and and CC cord-010119-t1x9gknd 10990 17 promotes promote VBZ cord-010119-t1x9gknd 10990 18 faster fast JJR cord-010119-t1x9gknd 10990 19 recovery recovery NN cord-010119-t1x9gknd 10990 20 . . . cord-010119-t1x9gknd 10991 1 A a DT cord-010119-t1x9gknd 10991 2 previous previous JJ cord-010119-t1x9gknd 10991 3 project project NN cord-010119-t1x9gknd 10991 4 explaining explain VBG cord-010119-t1x9gknd 10991 5 TPE TPE NNP cord-010119-t1x9gknd 10991 6 to to IN cord-010119-t1x9gknd 10991 7 the the DT cord-010119-t1x9gknd 10991 8 pediatric pediatric JJ cord-010119-t1x9gknd 10991 9 population population NN cord-010119-t1x9gknd 10991 10 revealed reveal VBD cord-010119-t1x9gknd 10991 11 the the DT cord-010119-t1x9gknd 10991 12 lack lack NN cord-010119-t1x9gknd 10991 13 of of IN cord-010119-t1x9gknd 10991 14 age age NN cord-010119-t1x9gknd 10991 15 specific specific JJ cord-010119-t1x9gknd 10991 16 literature literature NN cord-010119-t1x9gknd 10991 17 for for IN cord-010119-t1x9gknd 10991 18 apheresis apheresis NN cord-010119-t1x9gknd 10991 19 procedures procedure NNS cord-010119-t1x9gknd 10991 20 in in IN cord-010119-t1x9gknd 10991 21 general general JJ cord-010119-t1x9gknd 10991 22 , , , cord-010119-t1x9gknd 10991 23 including include VBG cord-010119-t1x9gknd 10991 24 TPE TPE NNP cord-010119-t1x9gknd 10991 25 and and CC cord-010119-t1x9gknd 10991 26 RBC RBC NNP cord-010119-t1x9gknd 10991 27 exchange exchange NN cord-010119-t1x9gknd 10991 28 . . . cord-010119-t1x9gknd 10992 1 Study Study NNP cord-010119-t1x9gknd 10992 2 Design Design NNP cord-010119-t1x9gknd 10992 3 / / SYM cord-010119-t1x9gknd 10992 4 Method method NN cord-010119-t1x9gknd 10992 5 : : : cord-010119-t1x9gknd 10993 1 In in IN cord-010119-t1x9gknd 10993 2 collaboration collaboration NN cord-010119-t1x9gknd 10993 3 with with IN cord-010119-t1x9gknd 10993 4 a a DT cord-010119-t1x9gknd 10993 5 Child Child NNP cord-010119-t1x9gknd 10993 6 Life Life NNP cord-010119-t1x9gknd 10993 7 Specialist Specialist NNP cord-010119-t1x9gknd 10993 8 , , , cord-010119-t1x9gknd 10993 9 an an DT cord-010119-t1x9gknd 10993 10 ageappropriate ageappropriate NN cord-010119-t1x9gknd 10993 11 story story NN cord-010119-t1x9gknd 10993 12 - - HYPH cord-010119-t1x9gknd 10993 13 driven drive VBN cord-010119-t1x9gknd 10993 14 explanation explanation NN cord-010119-t1x9gknd 10993 15 of of IN cord-010119-t1x9gknd 10993 16 the the DT cord-010119-t1x9gknd 10993 17 RBC RBC NNP cord-010119-t1x9gknd 10993 18 exchange exchange NN cord-010119-t1x9gknd 10993 19 procedure procedure NN cord-010119-t1x9gknd 10993 20 was be VBD cord-010119-t1x9gknd 10993 21 adapted adapt VBN cord-010119-t1x9gknd 10993 22 from from IN cord-010119-t1x9gknd 10993 23 a a DT cord-010119-t1x9gknd 10993 24 previously previously RB cord-010119-t1x9gknd 10993 25 implemented implement VBN cord-010119-t1x9gknd 10993 26 project project NN cord-010119-t1x9gknd 10993 27 related relate VBN cord-010119-t1x9gknd 10993 28 to to IN cord-010119-t1x9gknd 10993 29 TPE TPE NNP cord-010119-t1x9gknd 10993 30 . . . cord-010119-t1x9gknd 10994 1 Artwork artwork NN cord-010119-t1x9gknd 10994 2 was be VBD cord-010119-t1x9gknd 10994 3 produced produce VBN cord-010119-t1x9gknd 10994 4 with with IN cord-010119-t1x9gknd 10994 5 the the DT cord-010119-t1x9gknd 10994 6 aid aid NN cord-010119-t1x9gknd 10994 7 of of IN cord-010119-t1x9gknd 10994 8 a a DT cord-010119-t1x9gknd 10994 9 medical medical JJ cord-010119-t1x9gknd 10994 10 illustrator illustrator NN cord-010119-t1x9gknd 10994 11 to to TO cord-010119-t1x9gknd 10994 12 complement complement VB cord-010119-t1x9gknd 10994 13 the the DT cord-010119-t1x9gknd 10994 14 story story NN cord-010119-t1x9gknd 10994 15 - - HYPH cord-010119-t1x9gknd 10994 16 line line NN cord-010119-t1x9gknd 10994 17 . . . cord-010119-t1x9gknd 10995 1 Results/ Results/ . cord-010119-t1x9gknd 10996 1 Finding finding NN cord-010119-t1x9gknd 10996 2 : : : cord-010119-t1x9gknd 10997 1 The the DT cord-010119-t1x9gknd 10997 2 story story NN cord-010119-t1x9gknd 10997 3 board board NN cord-010119-t1x9gknd 10997 4 addresses address VBZ cord-010119-t1x9gknd 10997 5 why why WRB cord-010119-t1x9gknd 10997 6 RBC RBC NNP cord-010119-t1x9gknd 10997 7 exchange exchange NN cord-010119-t1x9gknd 10997 8 is be VBZ cord-010119-t1x9gknd 10997 9 performed perform VBN cord-010119-t1x9gknd 10997 10 , , , cord-010119-t1x9gknd 10997 11 the the DT cord-010119-t1x9gknd 10997 12 steps step NNS cord-010119-t1x9gknd 10997 13 involved involve VBN cord-010119-t1x9gknd 10997 14 in in IN cord-010119-t1x9gknd 10997 15 preparing prepare VBG cord-010119-t1x9gknd 10997 16 for for IN cord-010119-t1x9gknd 10997 17 and and CC cord-010119-t1x9gknd 10997 18 performing perform VBG cord-010119-t1x9gknd 10997 19 the the DT cord-010119-t1x9gknd 10997 20 procedure procedure NN cord-010119-t1x9gknd 10997 21 , , , cord-010119-t1x9gknd 10997 22 and and CC cord-010119-t1x9gknd 10997 23 strategies strategy NNS cord-010119-t1x9gknd 10997 24 for for IN cord-010119-t1x9gknd 10997 25 coping cope VBG cord-010119-t1x9gknd 10997 26 before before RB cord-010119-t1x9gknd 10997 27 , , , cord-010119-t1x9gknd 10997 28 during during IN cord-010119-t1x9gknd 10997 29 and and CC cord-010119-t1x9gknd 10997 30 after after IN cord-010119-t1x9gknd 10997 31 the the DT cord-010119-t1x9gknd 10997 32 procedure procedure NN cord-010119-t1x9gknd 10997 33 . . . cord-010119-t1x9gknd 10998 1 The the DT cord-010119-t1x9gknd 10998 2 idea idea NN cord-010119-t1x9gknd 10998 3 of of IN cord-010119-t1x9gknd 10998 4 long long JJ cord-010119-t1x9gknd 10998 5 - - HYPH cord-010119-t1x9gknd 10998 6 term term NN cord-010119-t1x9gknd 10998 7 therapy therapy NN cord-010119-t1x9gknd 10998 8 is be VBZ cord-010119-t1x9gknd 10998 9 also also RB cord-010119-t1x9gknd 10998 10 briefly briefly RB cord-010119-t1x9gknd 10998 11 addressed address VBN cord-010119-t1x9gknd 10998 12 , , , cord-010119-t1x9gknd 10998 13 to to TO cord-010119-t1x9gknd 10998 14 prepare prepare VB cord-010119-t1x9gknd 10998 15 these these DT cord-010119-t1x9gknd 10998 16 children child NNS cord-010119-t1x9gknd 10998 17 for for IN cord-010119-t1x9gknd 10998 18 the the DT cord-010119-t1x9gknd 10998 19 concept concept NN cord-010119-t1x9gknd 10998 20 of of IN cord-010119-t1x9gknd 10998 21 ongoing ongoing JJ cord-010119-t1x9gknd 10998 22 therapy therapy NN cord-010119-t1x9gknd 10998 23 . . . cord-010119-t1x9gknd 10999 1 The the DT cord-010119-t1x9gknd 10999 2 booklet booklet NN cord-010119-t1x9gknd 10999 3 is be VBZ cord-010119-t1x9gknd 10999 4 in in IN cord-010119-t1x9gknd 10999 5 production production NN cord-010119-t1x9gknd 10999 6 in in IN cord-010119-t1x9gknd 10999 7 concert concert NN cord-010119-t1x9gknd 10999 8 with with IN cord-010119-t1x9gknd 10999 9 our -PRON- PRP$ cord-010119-t1x9gknd 10999 10 hospital hospital NN cord-010119-t1x9gknd 10999 11 's 's POS cord-010119-t1x9gknd 10999 12 medical medical JJ cord-010119-t1x9gknd 10999 13 illustrator illustrator NN cord-010119-t1x9gknd 10999 14 and and CC cord-010119-t1x9gknd 10999 15 will will MD cord-010119-t1x9gknd 10999 16 be be VB cord-010119-t1x9gknd 10999 17 available available JJ cord-010119-t1x9gknd 10999 18 on on IN cord-010119-t1x9gknd 10999 19 our -PRON- PRP$ cord-010119-t1x9gknd 10999 20 hospital hospital NN cord-010119-t1x9gknd 10999 21 website website NN cord-010119-t1x9gknd 10999 22 for for IN cord-010119-t1x9gknd 10999 23 patient patient JJ cord-010119-t1x9gknd 10999 24 use use NN cord-010119-t1x9gknd 10999 25 . . . cord-010119-t1x9gknd 11000 1 Conclusion conclusion NN cord-010119-t1x9gknd 11000 2 : : : cord-010119-t1x9gknd 11000 3 Using use VBG cord-010119-t1x9gknd 11000 4 the the DT cord-010119-t1x9gknd 11000 5 previously previously RB cord-010119-t1x9gknd 11000 6 illustrated illustrate VBN cord-010119-t1x9gknd 11000 7 story story NN cord-010119-t1x9gknd 11000 8 as as IN cord-010119-t1x9gknd 11000 9 a a DT cord-010119-t1x9gknd 11000 10 guide guide NN cord-010119-t1x9gknd 11000 11 , , , cord-010119-t1x9gknd 11000 12 an an DT cord-010119-t1x9gknd 11000 13 explanation explanation NN cord-010119-t1x9gknd 11000 14 of of IN cord-010119-t1x9gknd 11000 15 red red JJ cord-010119-t1x9gknd 11000 16 cell cell NN cord-010119-t1x9gknd 11000 17 exchange exchange NN cord-010119-t1x9gknd 11000 18 was be VBD cord-010119-t1x9gknd 11000 19 created create VBN cord-010119-t1x9gknd 11000 20 to to TO cord-010119-t1x9gknd 11000 21 provide provide VB cord-010119-t1x9gknd 11000 22 education education NN cord-010119-t1x9gknd 11000 23 and and CC cord-010119-t1x9gknd 11000 24 reduce reduce VB cord-010119-t1x9gknd 11000 25 anxiety anxiety NN cord-010119-t1x9gknd 11000 26 . . . cord-010119-t1x9gknd 11001 1 This this DT cord-010119-t1x9gknd 11001 2 second second JJ cord-010119-t1x9gknd 11001 3 installment installment NN cord-010119-t1x9gknd 11001 4 continues continue VBZ cord-010119-t1x9gknd 11001 5 the the DT cord-010119-t1x9gknd 11001 6 pediatric pediatric JJ cord-010119-t1x9gknd 11001 7 series series NN cord-010119-t1x9gknd 11001 8 helping help VBG cord-010119-t1x9gknd 11001 9 to to TO cord-010119-t1x9gknd 11001 10 explain explain VB cord-010119-t1x9gknd 11001 11 apheresis apheresis NN cord-010119-t1x9gknd 11001 12 procedures procedure NNS cord-010119-t1x9gknd 11001 13 to to IN cord-010119-t1x9gknd 11001 14 pediatric pediatric JJ cord-010119-t1x9gknd 11001 15 populations population NNS cord-010119-t1x9gknd 11001 16 in in IN cord-010119-t1x9gknd 11001 17 the the DT cord-010119-t1x9gknd 11001 18 hopes hope NNS cord-010119-t1x9gknd 11001 19 of of IN cord-010119-t1x9gknd 11001 20 reducing reduce VBG cord-010119-t1x9gknd 11001 21 patient patient JJ cord-010119-t1x9gknd 11001 22 stress stress NN cord-010119-t1x9gknd 11001 23 and and CC cord-010119-t1x9gknd 11001 24 promoting promote VBG cord-010119-t1x9gknd 11001 25 age age NN cord-010119-t1x9gknd 11001 26 appropriate appropriate JJ cord-010119-t1x9gknd 11001 27 coping cope VBG cord-010119-t1x9gknd 11001 28 strategies strategy NNS cord-010119-t1x9gknd 11001 29 . . . cord-010119-t1x9gknd 11002 1 Transfusion Transfusion NNP cord-010119-t1x9gknd 11002 2 Safety Safety NNP cord-010119-t1x9gknd 11002 3 Officer Officer NNP cord-010119-t1x9gknd 11002 4 Resource Resource NNP cord-010119-t1x9gknd 11002 5 Manual Manual NNP cord-010119-t1x9gknd 11002 6 Leonor Leonor NNP cord-010119-t1x9gknd 11002 7 De De NNP cord-010119-t1x9gknd 11002 8 Biasio Biasio NNP cord-010119-t1x9gknd 11003 1 * * NFP cord-010119-t1x9gknd 11003 2 . . . cord-010119-t1x9gknd 11004 1 It -PRON- PRP cord-010119-t1x9gknd 11004 2 is be VBZ cord-010119-t1x9gknd 11004 3 also also RB cord-010119-t1x9gknd 11004 4 intended intend VBN cord-010119-t1x9gknd 11004 5 to to TO cord-010119-t1x9gknd 11004 6 be be VB cord-010119-t1x9gknd 11004 7 utilized utilize VBN cord-010119-t1x9gknd 11004 8 by by IN cord-010119-t1x9gknd 11004 9 hospitals hospital NNS cord-010119-t1x9gknd 11004 10 that that WDT cord-010119-t1x9gknd 11004 11 do do VBP cord-010119-t1x9gknd 11004 12 not not RB cord-010119-t1x9gknd 11004 13 have have VB cord-010119-t1x9gknd 11004 14 a a DT cord-010119-t1x9gknd 11004 15 formal formal JJ cord-010119-t1x9gknd 11004 16 TSO TSO NNP cord-010119-t1x9gknd 11004 17 position position NN cord-010119-t1x9gknd 11004 18 but but CC cord-010119-t1x9gknd 11004 19 which which WDT cord-010119-t1x9gknd 11004 20 have have VBP cord-010119-t1x9gknd 11004 21 delegated delegate VBN cord-010119-t1x9gknd 11004 22 the the DT cord-010119-t1x9gknd 11004 23 responsibilities responsibility NNS cord-010119-t1x9gknd 11004 24 to to IN cord-010119-t1x9gknd 11004 25 other other JJ cord-010119-t1x9gknd 11004 26 staff staff NN cord-010119-t1x9gknd 11004 27 . . . cord-010119-t1x9gknd 11005 1 The the DT cord-010119-t1x9gknd 11005 2 resource resource NN cord-010119-t1x9gknd 11005 3 provides provide VBZ cord-010119-t1x9gknd 11005 4 helpful helpful JJ cord-010119-t1x9gknd 11005 5 information information NN cord-010119-t1x9gknd 11005 6 to to TO cord-010119-t1x9gknd 11005 7 assist assist VB cord-010119-t1x9gknd 11005 8 with with IN cord-010119-t1x9gknd 11005 9 education education NN cord-010119-t1x9gknd 11005 10 in in IN cord-010119-t1x9gknd 11005 11 transfusion transfusion NN cord-010119-t1x9gknd 11005 12 safety safety NN cord-010119-t1x9gknd 11005 13 , , , cord-010119-t1x9gknd 11005 14 adverse adverse JJ cord-010119-t1x9gknd 11005 15 event event NN cord-010119-t1x9gknd 11005 16 investigation investigation NN cord-010119-t1x9gknd 11005 17 and and CC cord-010119-t1x9gknd 11005 18 reporting reporting NN cord-010119-t1x9gknd 11005 19 , , , cord-010119-t1x9gknd 11005 20 product product NN cord-010119-t1x9gknd 11005 21 administration administration NN cord-010119-t1x9gknd 11005 22 guidelines guideline NNS cord-010119-t1x9gknd 11005 23 or or CC cord-010119-t1x9gknd 11005 24 monographs monograph NNS cord-010119-t1x9gknd 11005 25 , , , cord-010119-t1x9gknd 11005 26 and and CC cord-010119-t1x9gknd 11005 27 links link NNS cord-010119-t1x9gknd 11005 28 to to IN cord-010119-t1x9gknd 11005 29 information information NN cord-010119-t1x9gknd 11005 30 about about IN cord-010119-t1x9gknd 11005 31 the the DT cord-010119-t1x9gknd 11005 32 equipment equipment NN cord-010119-t1x9gknd 11005 33 used use VBN cord-010119-t1x9gknd 11005 34 for for IN cord-010119-t1x9gknd 11005 35 infusion infusion NN cord-010119-t1x9gknd 11005 36 of of IN cord-010119-t1x9gknd 11005 37 blood blood NN cord-010119-t1x9gknd 11005 38 . . . cord-010119-t1x9gknd 11006 1 The the DT cord-010119-t1x9gknd 11006 2 resource resource NN cord-010119-t1x9gknd 11006 3 manual manual NN cord-010119-t1x9gknd 11006 4 will will MD cord-010119-t1x9gknd 11006 5 serve serve VB cord-010119-t1x9gknd 11006 6 as as IN cord-010119-t1x9gknd 11006 7 a a DT cord-010119-t1x9gknd 11006 8 useful useful JJ cord-010119-t1x9gknd 11006 9 reference reference NN cord-010119-t1x9gknd 11006 10 tool tool NN cord-010119-t1x9gknd 11006 11 to to TO cord-010119-t1x9gknd 11006 12 assist assist VB cord-010119-t1x9gknd 11006 13 with with IN cord-010119-t1x9gknd 11006 14 a a DT cord-010119-t1x9gknd 11006 15 healthcare healthcare NN cord-010119-t1x9gknd 11006 16 professional professional NN cord-010119-t1x9gknd 11006 17 's 's POS cord-010119-t1x9gknd 11006 18 transition transition NN cord-010119-t1x9gknd 11006 19 into into IN cord-010119-t1x9gknd 11006 20 the the DT cord-010119-t1x9gknd 11006 21 TSO TSO NNP cord-010119-t1x9gknd 11006 22 role role NN cord-010119-t1x9gknd 11006 23 . . . cord-010119-t1x9gknd 11007 1 Turning turn VBG cord-010119-t1x9gknd 11007 2 on on IN cord-010119-t1x9gknd 11007 3 Pathogen Pathogen NNP cord-010119-t1x9gknd 11007 4 Reduction Reduction NNP cord-010119-t1x9gknd 11007 5 : : : cord-010119-t1x9gknd 11008 1 A a DT cord-010119-t1x9gknd 11008 2 Case case NN cord-010119-t1x9gknd 11008 3 of of IN cord-010119-t1x9gknd 11008 4 Flipping flip VBG cord-010119-t1x9gknd 11008 5 the the DT cord-010119-t1x9gknd 11008 6 Switch Switch NNP cord-010119-t1x9gknd 11008 7 Kassandra Kassandra NNP cord-010119-t1x9gknd 11008 8 Poffenberger Poffenberger NNP cord-010119-t1x9gknd 11008 9 * * NFP cord-010119-t1x9gknd 11008 10 , , , cord-010119-t1x9gknd 11008 11 Darla Darla NNP cord-010119-t1x9gknd 11008 12 Wendt Wendt NNP cord-010119-t1x9gknd 11008 13 , , , cord-010119-t1x9gknd 11008 14 Jennifer Jennifer NNP cord-010119-t1x9gknd 11008 15 Vrieze Vrieze NNP cord-010119-t1x9gknd 11008 16 and and CC cord-010119-t1x9gknd 11008 17 James James NNP cord-010119-t1x9gknd 11008 18 R R NNP cord-010119-t1x9gknd 11008 19 Stubbs Stubbs NNP cord-010119-t1x9gknd 11008 20 . . . cord-010119-t1x9gknd 11009 1 Mayo Mayo NNP cord-010119-t1x9gknd 11009 2 Clinic Clinic NNP cord-010119-t1x9gknd 11009 3 Background Background NNP cord-010119-t1x9gknd 11009 4 / / SYM cord-010119-t1x9gknd 11009 5 Case Case NNP cord-010119-t1x9gknd 11009 6 Studies Studies NNPS cord-010119-t1x9gknd 11009 7 : : : cord-010119-t1x9gknd 11010 1 A a DT cord-010119-t1x9gknd 11010 2 critical critical JJ cord-010119-t1x9gknd 11010 3 aspect aspect NN cord-010119-t1x9gknd 11010 4 of of IN cord-010119-t1x9gknd 11010 5 implementing implement VBG cord-010119-t1x9gknd 11010 6 a a DT cord-010119-t1x9gknd 11010 7 new new JJ cord-010119-t1x9gknd 11010 8 method method NN cord-010119-t1x9gknd 11010 9 in in IN cord-010119-t1x9gknd 11010 10 manufacturing manufacture VBG cord-010119-t1x9gknd 11010 11 blood blood NN cord-010119-t1x9gknd 11010 12 products product NNS cord-010119-t1x9gknd 11010 13 is be VBZ cord-010119-t1x9gknd 11010 14 to to TO cord-010119-t1x9gknd 11010 15 develop develop VB cord-010119-t1x9gknd 11010 16 a a DT cord-010119-t1x9gknd 11010 17 training training NN cord-010119-t1x9gknd 11010 18 plan plan NN cord-010119-t1x9gknd 11010 19 that that WDT cord-010119-t1x9gknd 11010 20 adequately adequately RB cord-010119-t1x9gknd 11010 21 prepares prepare VBZ cord-010119-t1x9gknd 11010 22 staff staff NN cord-010119-t1x9gknd 11010 23 but but CC cord-010119-t1x9gknd 11010 24 does do VBZ cord-010119-t1x9gknd 11010 25 n't not RB cord-010119-t1x9gknd 11010 26 interfere interfere VB cord-010119-t1x9gknd 11010 27 with with IN cord-010119-t1x9gknd 11010 28 production production NN cord-010119-t1x9gknd 11010 29 or or CC cord-010119-t1x9gknd 11010 30 cause cause VB cord-010119-t1x9gknd 11010 31 delays delay NNS cord-010119-t1x9gknd 11010 32 in in IN cord-010119-t1x9gknd 11010 33 patient patient JJ cord-010119-t1x9gknd 11010 34 care care NN cord-010119-t1x9gknd 11010 35 . . . cord-010119-t1x9gknd 11011 1 With with IN cord-010119-t1x9gknd 11011 2 the the DT cord-010119-t1x9gknd 11011 3 implementation implementation NN cord-010119-t1x9gknd 11011 4 of of IN cord-010119-t1x9gknd 11011 5 Pathogen Pathogen NNP cord-010119-t1x9gknd 11011 6 Reduction Reduction NNP cord-010119-t1x9gknd 11011 7 Technology Technology NNP cord-010119-t1x9gknd 11011 8 ( ( -LRB- cord-010119-t1x9gknd 11011 9 PRT PRT NNP cord-010119-t1x9gknd 11011 10 ) ) -RRB- cord-010119-t1x9gknd 11011 11 using use VBG cord-010119-t1x9gknd 11011 12 INTERCEPTV INTERCEPTV NNP cord-010119-t1x9gknd 11011 13 R R NNP cord-010119-t1x9gknd 11011 14 Blood blood NN cord-010119-t1x9gknd 11011 15 System system NN cord-010119-t1x9gknd 11011 16 for for IN cord-010119-t1x9gknd 11011 17 Platelets platelet NNS cord-010119-t1x9gknd 11012 1 it -PRON- PRP cord-010119-t1x9gknd 11012 2 was be VBD cord-010119-t1x9gknd 11012 3 understood understand VBN cord-010119-t1x9gknd 11012 4 that that IN cord-010119-t1x9gknd 11012 5 we -PRON- PRP cord-010119-t1x9gknd 11012 6 would would MD cord-010119-t1x9gknd 11012 7 need need VB cord-010119-t1x9gknd 11012 8 more more JJR cord-010119-t1x9gknd 11012 9 collections collection NNS cord-010119-t1x9gknd 11012 10 to to TO cord-010119-t1x9gknd 11012 11 make make VB cord-010119-t1x9gknd 11012 12 up up RP cord-010119-t1x9gknd 11012 13 for for IN cord-010119-t1x9gknd 11012 14 the the DT cord-010119-t1x9gknd 11012 15 loss loss NN cord-010119-t1x9gknd 11012 16 of of IN cord-010119-t1x9gknd 11012 17 products product NNS cord-010119-t1x9gknd 11012 18 , , , cord-010119-t1x9gknd 11012 19 specifically specifically RB cord-010119-t1x9gknd 11012 20 our -PRON- PRP$ cord-010119-t1x9gknd 11012 21 triple triple JJ cord-010119-t1x9gknd 11012 22 collections collection NNS cord-010119-t1x9gknd 11012 23 . . . cord-010119-t1x9gknd 11013 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11013 2 institution institution NN cord-010119-t1x9gknd 11013 3 collects collect VBZ cord-010119-t1x9gknd 11013 4 the the DT cord-010119-t1x9gknd 11013 5 majority majority NN cord-010119-t1x9gknd 11013 6 of of IN cord-010119-t1x9gknd 11013 7 its -PRON- PRP$ cord-010119-t1x9gknd 11013 8 blood blood NN cord-010119-t1x9gknd 11013 9 products product NNS cord-010119-t1x9gknd 11013 10 and and CC cord-010119-t1x9gknd 11013 11 supplements supplement NNS cord-010119-t1x9gknd 11013 12 inventory inventory NN cord-010119-t1x9gknd 11013 13 from from IN cord-010119-t1x9gknd 11013 14 a a DT cord-010119-t1x9gknd 11013 15 major major JJ cord-010119-t1x9gknd 11013 16 blood blood NN cord-010119-t1x9gknd 11013 17 collection collection NN cord-010119-t1x9gknd 11013 18 center center NN cord-010119-t1x9gknd 11013 19 . . . cord-010119-t1x9gknd 11014 1 It -PRON- PRP cord-010119-t1x9gknd 11014 2 was be VBD cord-010119-t1x9gknd 11014 3 crucial crucial JJ cord-010119-t1x9gknd 11014 4 for for IN cord-010119-t1x9gknd 11014 5 the the DT cord-010119-t1x9gknd 11014 6 Component Component NNP cord-010119-t1x9gknd 11014 7 Laboratory Laboratory NNP cord-010119-t1x9gknd 11014 8 to to TO cord-010119-t1x9gknd 11014 9 maintain maintain VB cord-010119-t1x9gknd 11014 10 daily daily JJ cord-010119-t1x9gknd 11014 11 processing processing NN cord-010119-t1x9gknd 11014 12 levels level NNS cord-010119-t1x9gknd 11014 13 while while IN cord-010119-t1x9gknd 11014 14 learning learn VBG cord-010119-t1x9gknd 11014 15 the the DT cord-010119-t1x9gknd 11014 16 new new JJ cord-010119-t1x9gknd 11014 17 method method NN cord-010119-t1x9gknd 11014 18 in in IN cord-010119-t1x9gknd 11014 19 order order NN cord-010119-t1x9gknd 11014 20 to to TO cord-010119-t1x9gknd 11014 21 sustain sustain VB cord-010119-t1x9gknd 11014 22 optimal optimal JJ cord-010119-t1x9gknd 11014 23 platelet platelet NN cord-010119-t1x9gknd 11014 24 inventory inventory NN cord-010119-t1x9gknd 11014 25 levels level NNS cord-010119-t1x9gknd 11014 26 without without IN cord-010119-t1x9gknd 11014 27 relying rely VBG cord-010119-t1x9gknd 11014 28 on on IN cord-010119-t1x9gknd 11014 29 purchasing purchase VBG cord-010119-t1x9gknd 11014 30 additional additional JJ cord-010119-t1x9gknd 11014 31 platelets platelet NNS cord-010119-t1x9gknd 11014 32 from from IN cord-010119-t1x9gknd 11014 33 external external JJ cord-010119-t1x9gknd 11014 34 vendors vendor NNS cord-010119-t1x9gknd 11014 35 . . . cord-010119-t1x9gknd 11015 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11015 2 approach approach NN cord-010119-t1x9gknd 11015 3 in in IN cord-010119-t1x9gknd 11015 4 introducing introduce VBG cord-010119-t1x9gknd 11015 5 PRT PRT NNP cord-010119-t1x9gknd 11015 6 for for IN cord-010119-t1x9gknd 11015 7 apheresis apheresis NN cord-010119-t1x9gknd 11015 8 platelets platelet NNS cord-010119-t1x9gknd 11015 9 was be VBD cord-010119-t1x9gknd 11015 10 to to TO cord-010119-t1x9gknd 11015 11 " " `` cord-010119-t1x9gknd 11015 12 flip flip VB cord-010119-t1x9gknd 11015 13 the the DT cord-010119-t1x9gknd 11015 14 switch switch NN cord-010119-t1x9gknd 11015 15 " " '' cord-010119-t1x9gknd 11015 16 and and CC cord-010119-t1x9gknd 11015 17 process process VB cord-010119-t1x9gknd 11015 18 all all DT cord-010119-t1x9gknd 11015 19 products product NNS cord-010119-t1x9gknd 11015 20 with with IN cord-010119-t1x9gknd 11015 21 the the DT cord-010119-t1x9gknd 11015 22 new new JJ cord-010119-t1x9gknd 11015 23 method method NN cord-010119-t1x9gknd 11015 24 rather rather RB cord-010119-t1x9gknd 11015 25 than than IN cord-010119-t1x9gknd 11015 26 a a DT cord-010119-t1x9gknd 11015 27 step step NN cord-010119-t1x9gknd 11015 28 wise wise JJ cord-010119-t1x9gknd 11015 29 roll roll VBP cord-010119-t1x9gknd 11015 30 out out RP cord-010119-t1x9gknd 11015 31 with with IN cord-010119-t1x9gknd 11015 32 a a DT cord-010119-t1x9gknd 11015 33 dual dual JJ cord-010119-t1x9gknd 11015 34 inventory inventory NN cord-010119-t1x9gknd 11015 35 . . . cord-010119-t1x9gknd 11016 1 Study Study NNP cord-010119-t1x9gknd 11016 2 Design Design NNP cord-010119-t1x9gknd 11016 3 / / SYM cord-010119-t1x9gknd 11016 4 Method method NN cord-010119-t1x9gknd 11016 5 : : : cord-010119-t1x9gknd 11016 6 It -PRON- PRP cord-010119-t1x9gknd 11016 7 was be VBD cord-010119-t1x9gknd 11016 8 essential essential JJ cord-010119-t1x9gknd 11016 9 to to TO cord-010119-t1x9gknd 11016 10 prioritize prioritize VB cord-010119-t1x9gknd 11016 11 who who WP cord-010119-t1x9gknd 11016 12 would would MD cord-010119-t1x9gknd 11016 13 be be VB cord-010119-t1x9gknd 11016 14 trained train VBN cord-010119-t1x9gknd 11016 15 first first RB cord-010119-t1x9gknd 11016 16 . . . cord-010119-t1x9gknd 11017 1 Collections collection NNS cord-010119-t1x9gknd 11017 2 occur occur VBP cord-010119-t1x9gknd 11017 3 Monday Monday NNP cord-010119-t1x9gknd 11017 4 through through IN cord-010119-t1x9gknd 11017 5 Friday Friday NNP cord-010119-t1x9gknd 11017 6 from from IN cord-010119-t1x9gknd 11017 7 0600 0600 CD cord-010119-t1x9gknd 11017 8 to to IN cord-010119-t1x9gknd 11017 9 1600 1600 CD cord-010119-t1x9gknd 11017 10 . . . cord-010119-t1x9gknd 11018 1 The the DT cord-010119-t1x9gknd 11018 2 first first JJ cord-010119-t1x9gknd 11018 3 group group NN cord-010119-t1x9gknd 11018 4 to to TO cord-010119-t1x9gknd 11018 5 be be VB cord-010119-t1x9gknd 11018 6 trained train VBN cord-010119-t1x9gknd 11018 7 was be VBD cord-010119-t1x9gknd 11018 8 those those DT cord-010119-t1x9gknd 11018 9 who who WP cord-010119-t1x9gknd 11018 10 would would MD cord-010119-t1x9gknd 11018 11 be be VB cord-010119-t1x9gknd 11018 12 performing perform VBG cord-010119-t1x9gknd 11018 13 training training NN cord-010119-t1x9gknd 11018 14 ( ( -LRB- cord-010119-t1x9gknd 11018 15 a a DT cord-010119-t1x9gknd 11018 16 two two CD cord-010119-t1x9gknd 11018 17 person person NN cord-010119-t1x9gknd 11018 18 team team NN cord-010119-t1x9gknd 11018 19 ) ) -RRB- cord-010119-t1x9gknd 11018 20 and and CC cord-010119-t1x9gknd 11018 21 product product NN cord-010119-t1x9gknd 11018 22 validation validation NN cord-010119-t1x9gknd 11018 23 ; ; : cord-010119-t1x9gknd 11018 24 they -PRON- PRP cord-010119-t1x9gknd 11018 25 were be VBD cord-010119-t1x9gknd 11018 26 trained train VBN cord-010119-t1x9gknd 11018 27 by by IN cord-010119-t1x9gknd 11018 28 Cerus Cerus NNP cord-010119-t1x9gknd 11018 29 deployment deployment NN cord-010119-t1x9gknd 11018 30 team team NN cord-010119-t1x9gknd 11018 31 . . . cord-010119-t1x9gknd 11019 1 The the DT cord-010119-t1x9gknd 11019 2 second second JJ cord-010119-t1x9gknd 11019 3 group group NN cord-010119-t1x9gknd 11019 4 was be VBD cord-010119-t1x9gknd 11019 5 those those DT cord-010119-t1x9gknd 11019 6 who who WP cord-010119-t1x9gknd 11019 7 would would MD cord-010119-t1x9gknd 11019 8 process process VB cord-010119-t1x9gknd 11019 9 platelets platelet NNS cord-010119-t1x9gknd 11019 10 on on IN cord-010119-t1x9gknd 11019 11 weekends weekend NNS cord-010119-t1x9gknd 11019 12 and and CC cord-010119-t1x9gknd 11019 13 evening evening NN cord-010119-t1x9gknd 11019 14 hours hour NNS cord-010119-t1x9gknd 11019 15 without without IN cord-010119-t1x9gknd 11019 16 direct direct JJ cord-010119-t1x9gknd 11019 17 management management NN cord-010119-t1x9gknd 11019 18 support support NN cord-010119-t1x9gknd 11019 19 . . . cord-010119-t1x9gknd 11020 1 The the DT cord-010119-t1x9gknd 11020 2 last last JJ cord-010119-t1x9gknd 11020 3 group group NN cord-010119-t1x9gknd 11020 4 was be VBD cord-010119-t1x9gknd 11020 5 the the DT cord-010119-t1x9gknd 11020 6 technologists technologist NNS cord-010119-t1x9gknd 11020 7 who who WP cord-010119-t1x9gknd 11020 8 would would MD cord-010119-t1x9gknd 11020 9 be be VB cord-010119-t1x9gknd 11020 10 working work VBG cord-010119-t1x9gknd 11020 11 during during IN cord-010119-t1x9gknd 11020 12 normal normal JJ cord-010119-t1x9gknd 11020 13 hours hour NNS cord-010119-t1x9gknd 11020 14 with with IN cord-010119-t1x9gknd 11020 15 direct direct JJ cord-010119-t1x9gknd 11020 16 management management NN cord-010119-t1x9gknd 11020 17 support support NN cord-010119-t1x9gknd 11020 18 . . . cord-010119-t1x9gknd 11021 1 PRT PRT NNP cord-010119-t1x9gknd 11021 2 processing processing NN cord-010119-t1x9gknd 11021 3 for for IN cord-010119-t1x9gknd 11021 4 platelets platelet NNS cord-010119-t1x9gknd 11021 5 in in IN cord-010119-t1x9gknd 11021 6 100 100 CD cord-010119-t1x9gknd 11021 7 % % NN cord-010119-t1x9gknd 11021 8 plasma plasma NN cord-010119-t1x9gknd 11021 9 is be VBZ cord-010119-t1x9gknd 11021 10 broken break VBN cord-010119-t1x9gknd 11021 11 up up RP cord-010119-t1x9gknd 11021 12 in in IN cord-010119-t1x9gknd 11021 13 to to IN cord-010119-t1x9gknd 11021 14 two two CD cord-010119-t1x9gknd 11021 15 days day NNS cord-010119-t1x9gknd 11021 16 . . . cord-010119-t1x9gknd 11022 1 On on IN cord-010119-t1x9gknd 11022 2 Day day NN cord-010119-t1x9gknd 11022 3 0 0 CD cord-010119-t1x9gknd 11022 4 platelets platelet NNS cord-010119-t1x9gknd 11022 5 are be VBP cord-010119-t1x9gknd 11022 6 treated treat VBN cord-010119-t1x9gknd 11022 7 with with IN cord-010119-t1x9gknd 11022 8 amotosalen amotosalen NN cord-010119-t1x9gknd 11022 9 and and CC cord-010119-t1x9gknd 11022 10 placed place VBN cord-010119-t1x9gknd 11022 11 in in IN cord-010119-t1x9gknd 11022 12 a a DT cord-010119-t1x9gknd 11022 13 Compound Compound NNP cord-010119-t1x9gknd 11022 14 Adsorption Adsorption NNP cord-010119-t1x9gknd 11022 15 Device device NN cord-010119-t1x9gknd 11022 16 to to TO cord-010119-t1x9gknd 11022 17 remove remove VB cord-010119-t1x9gknd 11022 18 residual residual JJ cord-010119-t1x9gknd 11022 19 amotosalen amotosalen NN cord-010119-t1x9gknd 11022 20 for for IN cord-010119-t1x9gknd 11022 21 12 12 CD cord-010119-t1x9gknd 11022 22 - - SYM cord-010119-t1x9gknd 11022 23 24 24 CD cord-010119-t1x9gknd 11022 24 hours hour NNS cord-010119-t1x9gknd 11022 25 . . . cord-010119-t1x9gknd 11023 1 On on IN cord-010119-t1x9gknd 11023 2 Day day NN cord-010119-t1x9gknd 11023 3 1 1 CD cord-010119-t1x9gknd 11023 4 products product NNS cord-010119-t1x9gknd 11023 5 are be VBP cord-010119-t1x9gknd 11023 6 removed remove VBN cord-010119-t1x9gknd 11023 7 from from IN cord-010119-t1x9gknd 11023 8 the the DT cord-010119-t1x9gknd 11023 9 CAD CAD NNP cord-010119-t1x9gknd 11023 10 and and CC cord-010119-t1x9gknd 11023 11 modified modify VBN cord-010119-t1x9gknd 11023 12 into into IN cord-010119-t1x9gknd 11023 13 final final JJ cord-010119-t1x9gknd 11023 14 product product NN cord-010119-t1x9gknd 11023 15 codes code NNS cord-010119-t1x9gknd 11023 16 and and CC cord-010119-t1x9gknd 11023 17 labeled label VBN cord-010119-t1x9gknd 11023 18 . . . cord-010119-t1x9gknd 11024 1 Each each DT cord-010119-t1x9gknd 11024 2 technologist technologist NN cord-010119-t1x9gknd 11024 3 was be VBD cord-010119-t1x9gknd 11024 4 trained train VBN cord-010119-t1x9gknd 11024 5 one one CD cord-010119-t1x9gknd 11024 6 on on IN cord-010119-t1x9gknd 11024 7 one one CD cord-010119-t1x9gknd 11024 8 , , , cord-010119-t1x9gknd 11024 9 over over IN cord-010119-t1x9gknd 11024 10 a a DT cord-010119-t1x9gknd 11024 11 one one CD cord-010119-t1x9gknd 11024 12 week week NN cord-010119-t1x9gknd 11024 13 period period NN cord-010119-t1x9gknd 11024 14 . . . cord-010119-t1x9gknd 11025 1 The the DT cord-010119-t1x9gknd 11025 2 trainers trainer NNS cord-010119-t1x9gknd 11025 3 alternated alternate VBD cord-010119-t1x9gknd 11025 4 training train VBG cord-010119-t1x9gknd 11025 5 processing processing NN cord-010119-t1x9gknd 11025 6 days day NNS cord-010119-t1x9gknd 11025 7 for for IN cord-010119-t1x9gknd 11025 8 Day day NN cord-010119-t1x9gknd 11025 9 0 0 CD cord-010119-t1x9gknd 11025 10 and and CC cord-010119-t1x9gknd 11025 11 Day day NN cord-010119-t1x9gknd 11025 12 1 1 CD cord-010119-t1x9gknd 11025 13 . . . cord-010119-t1x9gknd 11026 1 In in IN cord-010119-t1x9gknd 11026 2 the the DT cord-010119-t1x9gknd 11026 3 weeks week NNS cord-010119-t1x9gknd 11026 4 following follow VBG cord-010119-t1x9gknd 11026 5 training training NN cord-010119-t1x9gknd 11026 6 it -PRON- PRP cord-010119-t1x9gknd 11026 7 was be VBD cord-010119-t1x9gknd 11026 8 important important JJ cord-010119-t1x9gknd 11026 9 that that IN cord-010119-t1x9gknd 11026 10 each each DT cord-010119-t1x9gknd 11026 11 technologist technologist NN cord-010119-t1x9gknd 11026 12 rotated rotate VBD cord-010119-t1x9gknd 11026 13 back back RB cord-010119-t1x9gknd 11026 14 thru thru IN cord-010119-t1x9gknd 11026 15 PRT PRT NNP cord-010119-t1x9gknd 11026 16 processing processing NN cord-010119-t1x9gknd 11026 17 to to TO cord-010119-t1x9gknd 11026 18 maintain maintain VB cord-010119-t1x9gknd 11026 19 proficiency proficiency NN cord-010119-t1x9gknd 11026 20 . . . cord-010119-t1x9gknd 11027 1 Results result NNS cord-010119-t1x9gknd 11028 1 /Finding /Finding NNP cord-010119-t1x9gknd 11028 2 : : : cord-010119-t1x9gknd 11028 3 13 13 CD cord-010119-t1x9gknd 11028 4 of of IN cord-010119-t1x9gknd 11028 5 18 18 CD cord-010119-t1x9gknd 11028 6 employees employee NNS cord-010119-t1x9gknd 11028 7 were be VBD cord-010119-t1x9gknd 11028 8 trained train VBN cord-010119-t1x9gknd 11028 9 in in IN cord-010119-t1x9gknd 11028 10 a a DT cord-010119-t1x9gknd 11028 11 two two CD cord-010119-t1x9gknd 11028 12 month month NN cord-010119-t1x9gknd 11028 13 time time NN cord-010119-t1x9gknd 11028 14 period period NN cord-010119-t1x9gknd 11028 15 . . . cord-010119-t1x9gknd 11029 1 Prior prior RB cord-010119-t1x9gknd 11029 2 to to IN cord-010119-t1x9gknd 11029 3 " " `` cord-010119-t1x9gknd 11029 4 flipping flip VBG cord-010119-t1x9gknd 11029 5 the the DT cord-010119-t1x9gknd 11029 6 switch switch NN cord-010119-t1x9gknd 11029 7 " " `` cord-010119-t1x9gknd 11029 8 the the DT cord-010119-t1x9gknd 11029 9 daily daily JJ cord-010119-t1x9gknd 11029 10 average average NN cord-010119-t1x9gknd 11029 11 of of IN cord-010119-t1x9gknd 11029 12 products product NNS cord-010119-t1x9gknd 11029 13 collected collect VBN cord-010119-t1x9gknd 11029 14 was be VBD cord-010119-t1x9gknd 11029 15 21 21 CD cord-010119-t1x9gknd 11029 16 . . . cord-010119-t1x9gknd 11030 1 For for IN cord-010119-t1x9gknd 11030 2 the the DT cord-010119-t1x9gknd 11030 3 two two CD cord-010119-t1x9gknd 11030 4 month month NN cord-010119-t1x9gknd 11030 5 training training NN cord-010119-t1x9gknd 11030 6 period period NN cord-010119-t1x9gknd 11030 7 the the DT cord-010119-t1x9gknd 11030 8 daily daily JJ cord-010119-t1x9gknd 11030 9 average average NN cord-010119-t1x9gknd 11030 10 rose rise VBD cord-010119-t1x9gknd 11030 11 to to IN cord-010119-t1x9gknd 11030 12 23 23 CD cord-010119-t1x9gknd 11030 13 . . . cord-010119-t1x9gknd 11031 1 Conclusion conclusion NN cord-010119-t1x9gknd 11031 2 : : : cord-010119-t1x9gknd 11032 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11032 2 " " `` cord-010119-t1x9gknd 11032 3 flip flip VBP cord-010119-t1x9gknd 11032 4 the the DT cord-010119-t1x9gknd 11032 5 switch switch NN cord-010119-t1x9gknd 11032 6 " " `` cord-010119-t1x9gknd 11032 7 training training NN cord-010119-t1x9gknd 11032 8 plan plan NN cord-010119-t1x9gknd 11032 9 for for IN cord-010119-t1x9gknd 11032 10 implementing implement VBG cord-010119-t1x9gknd 11032 11 PRT PRT NNP cord-010119-t1x9gknd 11032 12 platelets platelet NNS cord-010119-t1x9gknd 11032 13 in in IN cord-010119-t1x9gknd 11032 14 100 100 CD cord-010119-t1x9gknd 11032 15 % % NN cord-010119-t1x9gknd 11032 16 plasma plasma NN cord-010119-t1x9gknd 11032 17 has have VBZ cord-010119-t1x9gknd 11032 18 been be VBN cord-010119-t1x9gknd 11032 19 highly highly RB cord-010119-t1x9gknd 11032 20 successful successful JJ cord-010119-t1x9gknd 11032 21 for for IN cord-010119-t1x9gknd 11032 22 our -PRON- PRP$ cord-010119-t1x9gknd 11032 23 laboratory laboratory NN cord-010119-t1x9gknd 11032 24 ; ; : cord-010119-t1x9gknd 11032 25 training training NN cord-010119-t1x9gknd 11032 26 while while IN cord-010119-t1x9gknd 11032 27 implementing implement VBG cord-010119-t1x9gknd 11032 28 the the DT cord-010119-t1x9gknd 11032 29 new new JJ cord-010119-t1x9gknd 11032 30 technology technology NN cord-010119-t1x9gknd 11032 31 did do VBD cord-010119-t1x9gknd 11032 32 not not RB cord-010119-t1x9gknd 11032 33 create create VB cord-010119-t1x9gknd 11032 34 a a DT cord-010119-t1x9gknd 11032 35 bottle bottle NN cord-010119-t1x9gknd 11032 36 - - HYPH cord-010119-t1x9gknd 11032 37 neck neck NN cord-010119-t1x9gknd 11032 38 in in IN cord-010119-t1x9gknd 11032 39 the the DT cord-010119-t1x9gknd 11032 40 process process NN cord-010119-t1x9gknd 11032 41 . . . cord-010119-t1x9gknd 11033 1 It -PRON- PRP cord-010119-t1x9gknd 11033 2 was be VBD cord-010119-t1x9gknd 11033 3 imperative imperative JJ cord-010119-t1x9gknd 11033 4 to to TO cord-010119-t1x9gknd 11033 5 prioritize prioritize VB cord-010119-t1x9gknd 11033 6 who who WP cord-010119-t1x9gknd 11033 7 would would MD cord-010119-t1x9gknd 11033 8 be be VB cord-010119-t1x9gknd 11033 9 trained train VBN cord-010119-t1x9gknd 11033 10 first first RB cord-010119-t1x9gknd 11033 11 to to TO cord-010119-t1x9gknd 11033 12 insure insure VB cord-010119-t1x9gknd 11033 13 complete complete JJ cord-010119-t1x9gknd 11033 14 coverage coverage NN cord-010119-t1x9gknd 11033 15 during during IN cord-010119-t1x9gknd 11033 16 off off IN cord-010119-t1x9gknd 11033 17 hour hour NN cord-010119-t1x9gknd 11033 18 shifts shift NNS cord-010119-t1x9gknd 11033 19 . . . cord-010119-t1x9gknd 11034 1 Technologists technologist NNS cord-010119-t1x9gknd 11034 2 were be VBD cord-010119-t1x9gknd 11034 3 able able JJ cord-010119-t1x9gknd 11034 4 to to TO cord-010119-t1x9gknd 11034 5 become become VB cord-010119-t1x9gknd 11034 6 proficient proficient JJ cord-010119-t1x9gknd 11034 7 with with IN cord-010119-t1x9gknd 11034 8 the the DT cord-010119-t1x9gknd 11034 9 new new JJ cord-010119-t1x9gknd 11034 10 process process NN cord-010119-t1x9gknd 11034 11 while while IN cord-010119-t1x9gknd 11034 12 maintaining maintain VBG cord-010119-t1x9gknd 11034 13 daily daily JJ cord-010119-t1x9gknd 11034 14 processing processing NN cord-010119-t1x9gknd 11034 15 expectations expectation NNS cord-010119-t1x9gknd 11034 16 and and CC cord-010119-t1x9gknd 11034 17 sustaining sustain VBG cord-010119-t1x9gknd 11034 18 an an DT cord-010119-t1x9gknd 11034 19 optimal optimal JJ cord-010119-t1x9gknd 11034 20 platelet platelet NN cord-010119-t1x9gknd 11034 21 inventory inventory NN cord-010119-t1x9gknd 11034 22 . . . cord-010119-t1x9gknd 11035 1 accepted accept VBN cord-010119-t1x9gknd 11035 2 depending depend VBG cord-010119-t1x9gknd 11035 3 on on IN cord-010119-t1x9gknd 11035 4 each each DT cord-010119-t1x9gknd 11035 5 individual individual NN cord-010119-t1x9gknd 11035 6 's 's POS cord-010119-t1x9gknd 11035 7 conscience conscience NN cord-010119-t1x9gknd 11035 8 . . . cord-010119-t1x9gknd 11036 1 Due due IN cord-010119-t1x9gknd 11036 2 to to IN cord-010119-t1x9gknd 11036 3 these these DT cord-010119-t1x9gknd 11036 4 unique unique JJ cord-010119-t1x9gknd 11036 5 medical medical JJ cord-010119-t1x9gknd 11036 6 challenges challenge NNS cord-010119-t1x9gknd 11036 7 , , , cord-010119-t1x9gknd 11036 8 it -PRON- PRP cord-010119-t1x9gknd 11036 9 is be VBZ cord-010119-t1x9gknd 11036 10 important important JJ cord-010119-t1x9gknd 11036 11 for for IN cord-010119-t1x9gknd 11036 12 caretakers caretaker NNS cord-010119-t1x9gknd 11036 13 to to TO cord-010119-t1x9gknd 11036 14 have have VB cord-010119-t1x9gknd 11036 15 an an DT cord-010119-t1x9gknd 11036 16 understanding understanding NN cord-010119-t1x9gknd 11036 17 of of IN cord-010119-t1x9gknd 11036 18 their -PRON- PRP$ cord-010119-t1x9gknd 11036 19 beliefs belief NNS cord-010119-t1x9gknd 11036 20 in in IN cord-010119-t1x9gknd 11036 21 order order NN cord-010119-t1x9gknd 11036 22 to to TO cord-010119-t1x9gknd 11036 23 provide provide VB cord-010119-t1x9gknd 11036 24 optimal optimal JJ cord-010119-t1x9gknd 11036 25 care care NN cord-010119-t1x9gknd 11036 26 . . . cord-010119-t1x9gknd 11037 1 We -PRON- PRP cord-010119-t1x9gknd 11037 2 describe describe VBP cord-010119-t1x9gknd 11037 3 the the DT cord-010119-t1x9gknd 11037 4 process process NN cord-010119-t1x9gknd 11037 5 of of IN cord-010119-t1x9gknd 11037 6 identifying identify VBG cord-010119-t1x9gknd 11037 7 JW JW NNP cord-010119-t1x9gknd 11037 8 in in IN cord-010119-t1x9gknd 11037 9 our -PRON- PRP$ cord-010119-t1x9gknd 11037 10 hospital hospital NN cord-010119-t1x9gknd 11037 11 and and CC cord-010119-t1x9gknd 11037 12 communicating communicate VBG cord-010119-t1x9gknd 11037 13 treatment treatment NN cord-010119-t1x9gknd 11037 14 needs need NNS cord-010119-t1x9gknd 11037 15 to to IN cord-010119-t1x9gknd 11037 16 staff staff NN cord-010119-t1x9gknd 11037 17 . . . cord-010119-t1x9gknd 11038 1 Study Study NNP cord-010119-t1x9gknd 11038 2 Design Design NNP cord-010119-t1x9gknd 11038 3 / / SYM cord-010119-t1x9gknd 11038 4 Methods method NNS cord-010119-t1x9gknd 11038 5 : : : cord-010119-t1x9gknd 11038 6 Proper proper JJ cord-010119-t1x9gknd 11038 7 treatment treatment NN cord-010119-t1x9gknd 11038 8 of of IN cord-010119-t1x9gknd 11038 9 JW JW NNP cord-010119-t1x9gknd 11038 10 requires require VBZ cord-010119-t1x9gknd 11038 11 the the DT cord-010119-t1x9gknd 11038 12 ability ability NN cord-010119-t1x9gknd 11038 13 to to TO cord-010119-t1x9gknd 11038 14 identify identify VB cord-010119-t1x9gknd 11038 15 the the DT cord-010119-t1x9gknd 11038 16 patient patient NN cord-010119-t1x9gknd 11038 17 and and CC cord-010119-t1x9gknd 11038 18 his -PRON- PRP$ cord-010119-t1x9gknd 11038 19 / / SYM cord-010119-t1x9gknd 11038 20 her -PRON- PRP$ cord-010119-t1x9gknd 11038 21 needs need NNS cord-010119-t1x9gknd 11038 22 . . . cord-010119-t1x9gknd 11039 1 When when WRB cord-010119-t1x9gknd 11039 2 a a DT cord-010119-t1x9gknd 11039 3 JW JW NNP cord-010119-t1x9gknd 11039 4 is be VBZ cord-010119-t1x9gknd 11039 5 admitted admit VBN cord-010119-t1x9gknd 11039 6 to to IN cord-010119-t1x9gknd 11039 7 our -PRON- PRP$ cord-010119-t1x9gknd 11039 8 hospital hospital NN cord-010119-t1x9gknd 11039 9 , , , cord-010119-t1x9gknd 11039 10 our -PRON- PRP$ cord-010119-t1x9gknd 11039 11 electronic electronic JJ cord-010119-t1x9gknd 11039 12 medical medical JJ cord-010119-t1x9gknd 11039 13 record record NN cord-010119-t1x9gknd 11039 14 ( ( -LRB- cord-010119-t1x9gknd 11039 15 EMR EMR NNP cord-010119-t1x9gknd 11039 16 ) ) -RRB- cord-010119-t1x9gknd 11039 17 triggers trigger VBZ cord-010119-t1x9gknd 11039 18 several several JJ cord-010119-t1x9gknd 11039 19 processes process NNS cord-010119-t1x9gknd 11039 20 based base VBN cord-010119-t1x9gknd 11039 21 on on IN cord-010119-t1x9gknd 11039 22 the the DT cord-010119-t1x9gknd 11039 23 patient patient NN cord-010119-t1x9gknd 11039 24 's 's POS cord-010119-t1x9gknd 11039 25 listed listed JJ cord-010119-t1x9gknd 11039 26 religion religion NN cord-010119-t1x9gknd 11039 27 . . . cord-010119-t1x9gknd 11040 1 One one CD cord-010119-t1x9gknd 11040 2 process process NN cord-010119-t1x9gknd 11040 3 creates create VBZ cord-010119-t1x9gknd 11040 4 an an DT cord-010119-t1x9gknd 11040 5 order order NN cord-010119-t1x9gknd 11040 6 that that WDT cord-010119-t1x9gknd 11040 7 reminds remind VBZ cord-010119-t1x9gknd 11040 8 caretakers caretaker NNS cord-010119-t1x9gknd 11040 9 to to TO cord-010119-t1x9gknd 11040 10 complete complete VB cord-010119-t1x9gknd 11040 11 the the DT cord-010119-t1x9gknd 11040 12 Declining Declining NNP cord-010119-t1x9gknd 11040 13 Blood Blood NNP cord-010119-t1x9gknd 11040 14 Consent Consent NNP cord-010119-t1x9gknd 11040 15 ( ( -LRB- cord-010119-t1x9gknd 11040 16 DBC DBC NNP cord-010119-t1x9gknd 11040 17 ) ) -RRB- cord-010119-t1x9gknd 11040 18 with with IN cord-010119-t1x9gknd 11040 19 the the DT cord-010119-t1x9gknd 11040 20 patient patient NN cord-010119-t1x9gknd 11040 21 . . . cord-010119-t1x9gknd 11041 1 The the DT cord-010119-t1x9gknd 11041 2 DBC DBC NNP cord-010119-t1x9gknd 11041 3 contains contain VBZ cord-010119-t1x9gknd 11041 4 language language NN cord-010119-t1x9gknd 11041 5 declining decline VBG cord-010119-t1x9gknd 11041 6 MABF MABF NNP cord-010119-t1x9gknd 11041 7 and and CC cord-010119-t1x9gknd 11041 8 reviews review VBZ cord-010119-t1x9gknd 11041 9 the the DT cord-010119-t1x9gknd 11041 10 MIBF MIBF NNP cord-010119-t1x9gknd 11041 11 with with IN cord-010119-t1x9gknd 11041 12 the the DT cord-010119-t1x9gknd 11041 13 patient patient NN cord-010119-t1x9gknd 11041 14 to to TO cord-010119-t1x9gknd 11041 15 identify identify VB cord-010119-t1x9gknd 11041 16 any any DT cord-010119-t1x9gknd 11041 17 that that DT cord-010119-t1x9gknd 11041 18 would would MD cord-010119-t1x9gknd 11041 19 be be VB cord-010119-t1x9gknd 11041 20 accepted accept VBN cord-010119-t1x9gknd 11041 21 . . . cord-010119-t1x9gknd 11042 1 The the DT cord-010119-t1x9gknd 11042 2 EMR EMR NNP cord-010119-t1x9gknd 11042 3 order order NN cord-010119-t1x9gknd 11042 4 regarding regard VBG cord-010119-t1x9gknd 11042 5 the the DT cord-010119-t1x9gknd 11042 6 DBC DBC NNP cord-010119-t1x9gknd 11042 7 provides provide VBZ cord-010119-t1x9gknd 11042 8 educational educational JJ cord-010119-t1x9gknd 11042 9 links link NNS cord-010119-t1x9gknd 11042 10 that that WDT cord-010119-t1x9gknd 11042 11 include include VBP cord-010119-t1x9gknd 11042 12 a a DT cord-010119-t1x9gknd 11042 13 bloodless bloodless JJ cord-010119-t1x9gknd 11042 14 policy policy NN cord-010119-t1x9gknd 11042 15 , , , cord-010119-t1x9gknd 11042 16 step step NN cord-010119-t1x9gknd 11042 17 - - HYPH cord-010119-t1x9gknd 11042 18 by by IN cord-010119-t1x9gknd 11042 19 - - HYPH cord-010119-t1x9gknd 11042 20 step step NN cord-010119-t1x9gknd 11042 21 instructions instruction NNS cord-010119-t1x9gknd 11042 22 on on IN cord-010119-t1x9gknd 11042 23 obtaining obtain VBG cord-010119-t1x9gknd 11042 24 the the DT cord-010119-t1x9gknd 11042 25 DBC DBC NNP cord-010119-t1x9gknd 11042 26 , , , cord-010119-t1x9gknd 11042 27 and and CC cord-010119-t1x9gknd 11042 28 information information NN cord-010119-t1x9gknd 11042 29 on on IN cord-010119-t1x9gknd 11042 30 alternatives alternative NNS cord-010119-t1x9gknd 11042 31 to to IN cord-010119-t1x9gknd 11042 32 transfusion transfusion NN cord-010119-t1x9gknd 11042 33 . . . cord-010119-t1x9gknd 11043 1 A a DT cord-010119-t1x9gknd 11043 2 second second JJ cord-010119-t1x9gknd 11043 3 EMR EMR NNP cord-010119-t1x9gknd 11043 4 process process NN cord-010119-t1x9gknd 11043 5 triggers trigger VBZ cord-010119-t1x9gknd 11043 6 a a DT cord-010119-t1x9gknd 11043 7 stop stop VB cord-010119-t1x9gknd 11043 8 - - HYPH cord-010119-t1x9gknd 11043 9 gate gate NN cord-010119-t1x9gknd 11043 10 to to TO cord-010119-t1x9gknd 11043 11 prevent prevent VB cord-010119-t1x9gknd 11043 12 the the DT cord-010119-t1x9gknd 11043 13 completion completion NN cord-010119-t1x9gknd 11043 14 of of IN cord-010119-t1x9gknd 11043 15 any any DT cord-010119-t1x9gknd 11043 16 MABF MABF NNP cord-010119-t1x9gknd 11043 17 order order NN cord-010119-t1x9gknd 11043 18 or or CC cord-010119-t1x9gknd 11043 19 MIBF MIBF NNP cord-010119-t1x9gknd 11043 20 order order NN cord-010119-t1x9gknd 11043 21 for for IN cord-010119-t1x9gknd 11043 22 a a DT cord-010119-t1x9gknd 11043 23 product product NN cord-010119-t1x9gknd 11043 24 that that IN cord-010119-t1x9gknd 11043 25 the the DT cord-010119-t1x9gknd 11043 26 patient patient NN cord-010119-t1x9gknd 11043 27 has have VBZ cord-010119-t1x9gknd 11043 28 declined decline VBN cord-010119-t1x9gknd 11043 29 . . . cord-010119-t1x9gknd 11044 1 A a DT cord-010119-t1x9gknd 11044 2 third third JJ cord-010119-t1x9gknd 11044 3 enrolls enroll VBZ cord-010119-t1x9gknd 11044 4 patients patient NNS cord-010119-t1x9gknd 11044 5 in in IN cord-010119-t1x9gknd 11044 6 the the DT cord-010119-t1x9gknd 11044 7 Minimal Minimal NNP cord-010119-t1x9gknd 11044 8 Blood Blood NNP cord-010119-t1x9gknd 11044 9 Volume Volume NNP cord-010119-t1x9gknd 11044 10 Labs Labs NNP cord-010119-t1x9gknd 11044 11 Protocol Protocol NNP cord-010119-t1x9gknd 11044 12 which which WDT cord-010119-t1x9gknd 11044 13 uses use VBZ cord-010119-t1x9gknd 11044 14 microtainers microtainer NNS cord-010119-t1x9gknd 11044 15 , , , cord-010119-t1x9gknd 11044 16 partial partial JJ cord-010119-t1x9gknd 11044 17 - - HYPH cord-010119-t1x9gknd 11044 18 fill fill NN cord-010119-t1x9gknd 11044 19 vacutainers vacutainer NNS cord-010119-t1x9gknd 11044 20 , , , cord-010119-t1x9gknd 11044 21 and and CC cord-010119-t1x9gknd 11044 22 blood blood NN cord-010119-t1x9gknd 11044 23 reservoir reservoir NN cord-010119-t1x9gknd 11044 24 sets set NNS cord-010119-t1x9gknd 11044 25 to to TO cord-010119-t1x9gknd 11044 26 reduce reduce VB cord-010119-t1x9gknd 11044 27 blood blood NN cord-010119-t1x9gknd 11044 28 loss loss NN cord-010119-t1x9gknd 11044 29 during during IN cord-010119-t1x9gknd 11044 30 draws draw NNS cord-010119-t1x9gknd 11044 31 . . . cord-010119-t1x9gknd 11045 1 Additionally additionally RB cord-010119-t1x9gknd 11045 2 , , , cord-010119-t1x9gknd 11045 3 at at IN cord-010119-t1x9gknd 11045 4 Registration registration NN cord-010119-t1x9gknd 11045 5 , , , cord-010119-t1x9gknd 11045 6 a a DT cord-010119-t1x9gknd 11045 7 Bloodless Bloodless NNP cord-010119-t1x9gknd 11045 8 Packet Packet NNP cord-010119-t1x9gknd 11045 9 is be VBZ cord-010119-t1x9gknd 11045 10 added add VBN cord-010119-t1x9gknd 11045 11 to to IN cord-010119-t1x9gknd 11045 12 the the DT cord-010119-t1x9gknd 11045 13 patient patient NN cord-010119-t1x9gknd 11045 14 's 's POS cord-010119-t1x9gknd 11045 15 paper paper NN cord-010119-t1x9gknd 11045 16 chart chart NN cord-010119-t1x9gknd 11045 17 . . . cord-010119-t1x9gknd 11046 1 This this DT cord-010119-t1x9gknd 11046 2 Packet packet NN cord-010119-t1x9gknd 11046 3 contains contain VBZ cord-010119-t1x9gknd 11046 4 the the DT cord-010119-t1x9gknd 11046 5 DBC DBC NNP cord-010119-t1x9gknd 11046 6 , , , cord-010119-t1x9gknd 11046 7 a a DT cord-010119-t1x9gknd 11046 8 glossary glossary NN cord-010119-t1x9gknd 11046 9 of of IN cord-010119-t1x9gknd 11046 10 DBC DBC NNP cord-010119-t1x9gknd 11046 11 terms term NNS cord-010119-t1x9gknd 11046 12 , , , cord-010119-t1x9gknd 11046 13 a a DT cord-010119-t1x9gknd 11046 14 bloodless bloodless JJ cord-010119-t1x9gknd 11046 15 sign sign NN cord-010119-t1x9gknd 11046 16 to to TO cord-010119-t1x9gknd 11046 17 be be VB cord-010119-t1x9gknd 11046 18 placed place VBN cord-010119-t1x9gknd 11046 19 over over IN cord-010119-t1x9gknd 11046 20 the the DT cord-010119-t1x9gknd 11046 21 patient patient NN cord-010119-t1x9gknd 11046 22 's 's POS cord-010119-t1x9gknd 11046 23 bed bed NN cord-010119-t1x9gknd 11046 24 , , , cord-010119-t1x9gknd 11046 25 a a DT cord-010119-t1x9gknd 11046 26 bloodless bloodless JJ cord-010119-t1x9gknd 11046 27 wristband wristband NN cord-010119-t1x9gknd 11046 28 to to TO cord-010119-t1x9gknd 11046 29 be be VB cord-010119-t1x9gknd 11046 30 worn wear VBN cord-010119-t1x9gknd 11046 31 by by IN cord-010119-t1x9gknd 11046 32 the the DT cord-010119-t1x9gknd 11046 33 patient patient NN cord-010119-t1x9gknd 11046 34 , , , cord-010119-t1x9gknd 11046 35 and and CC cord-010119-t1x9gknd 11046 36 two two CD cord-010119-t1x9gknd 11046 37 bloodless bloodless JJ cord-010119-t1x9gknd 11046 38 chart chart NN cord-010119-t1x9gknd 11046 39 stickers sticker NNS cord-010119-t1x9gknd 11046 40 that that WDT cord-010119-t1x9gknd 11046 41 are be VBP cord-010119-t1x9gknd 11046 42 added add VBN cord-010119-t1x9gknd 11046 43 to to IN cord-010119-t1x9gknd 11046 44 the the DT cord-010119-t1x9gknd 11046 45 outside outside NN cord-010119-t1x9gknd 11046 46 of of IN cord-010119-t1x9gknd 11046 47 the the DT cord-010119-t1x9gknd 11046 48 chart chart NN cord-010119-t1x9gknd 11046 49 . . . cord-010119-t1x9gknd 11047 1 These these DT cord-010119-t1x9gknd 11047 2 steps step NNS cord-010119-t1x9gknd 11047 3 remind remind VBP cord-010119-t1x9gknd 11047 4 the the DT cord-010119-t1x9gknd 11047 5 caretakers caretaker NNS cord-010119-t1x9gknd 11047 6 of of IN cord-010119-t1x9gknd 11047 7 the the DT cord-010119-t1x9gknd 11047 8 patient patient NN cord-010119-t1x9gknd 11047 9 's 's POS cord-010119-t1x9gknd 11047 10 special special JJ cord-010119-t1x9gknd 11047 11 requests request NNS cord-010119-t1x9gknd 11047 12 . . . cord-010119-t1x9gknd 11048 1 Finally finally RB cord-010119-t1x9gknd 11048 2 , , , cord-010119-t1x9gknd 11048 3 the the DT cord-010119-t1x9gknd 11048 4 Patient Patient NNP cord-010119-t1x9gknd 11048 5 Blood Blood NNP cord-010119-t1x9gknd 11048 6 Management Management NNP cord-010119-t1x9gknd 11048 7 ( ( -LRB- cord-010119-t1x9gknd 11048 8 PBM PBM NNP cord-010119-t1x9gknd 11048 9 ) ) -RRB- cord-010119-t1x9gknd 11048 10 Department Department NNP cord-010119-t1x9gknd 11048 11 receives receive VBZ cord-010119-t1x9gknd 11048 12 EMR EMR NNP cord-010119-t1x9gknd 11048 13 developed develop VBN cord-010119-t1x9gknd 11048 14 reports report NNS cord-010119-t1x9gknd 11048 15 which which WDT cord-010119-t1x9gknd 11048 16 identify identify VBP cord-010119-t1x9gknd 11048 17 JW JW NNP cord-010119-t1x9gknd 11048 18 presenting present VBG cord-010119-t1x9gknd 11048 19 to to IN cord-010119-t1x9gknd 11048 20 the the DT cord-010119-t1x9gknd 11048 21 hospital hospital NN cord-010119-t1x9gknd 11048 22 . . . cord-010119-t1x9gknd 11049 1 These these DT cord-010119-t1x9gknd 11049 2 patients patient NNS cord-010119-t1x9gknd 11049 3 are be VBP cord-010119-t1x9gknd 11049 4 followed follow VBN cord-010119-t1x9gknd 11049 5 by by IN cord-010119-t1x9gknd 11049 6 the the DT cord-010119-t1x9gknd 11049 7 PBM PBM NNP cord-010119-t1x9gknd 11049 8 nurses nurse NNS cord-010119-t1x9gknd 11049 9 and and CC cord-010119-t1x9gknd 11049 10 medical medical JJ cord-010119-t1x9gknd 11049 11 director director NN cord-010119-t1x9gknd 11049 12 during during IN cord-010119-t1x9gknd 11049 13 the the DT cord-010119-t1x9gknd 11049 14 duration duration NN cord-010119-t1x9gknd 11049 15 of of IN cord-010119-t1x9gknd 11049 16 care care NN cord-010119-t1x9gknd 11049 17 . . . cord-010119-t1x9gknd 11050 1 Treatment treatment NN cord-010119-t1x9gknd 11050 2 plans plan NNS cord-010119-t1x9gknd 11050 3 to to TO cord-010119-t1x9gknd 11050 4 optimize optimize VB cord-010119-t1x9gknd 11050 5 hemoglobin hemoglobin NN cord-010119-t1x9gknd 11050 6 , , , cord-010119-t1x9gknd 11050 7 oxygen oxygen NN cord-010119-t1x9gknd 11050 8 carrying carrying NN cord-010119-t1x9gknd 11050 9 capacity capacity NN cord-010119-t1x9gknd 11050 10 , , , cord-010119-t1x9gknd 11050 11 and and CC cord-010119-t1x9gknd 11050 12 hemostasis hemostasis NN cord-010119-t1x9gknd 11050 13 are be VBP cord-010119-t1x9gknd 11050 14 discussed discuss VBN cord-010119-t1x9gknd 11050 15 with with IN cord-010119-t1x9gknd 11050 16 the the DT cord-010119-t1x9gknd 11050 17 bedside bedside NN cord-010119-t1x9gknd 11050 18 caretakers caretaker NNS cord-010119-t1x9gknd 11050 19 and and CC cord-010119-t1x9gknd 11050 20 implemented implement VBD cord-010119-t1x9gknd 11050 21 as as IN cord-010119-t1x9gknd 11050 22 needed need VBN cord-010119-t1x9gknd 11050 23 . . . cord-010119-t1x9gknd 11051 1 Results result NNS cord-010119-t1x9gknd 11051 2 / / SYM cord-010119-t1x9gknd 11051 3 Findings finding NNS cord-010119-t1x9gknd 11051 4 : : : cord-010119-t1x9gknd 11051 5 Nearly nearly RB cord-010119-t1x9gknd 11051 6 100 100 CD cord-010119-t1x9gknd 11051 7 % % NN cord-010119-t1x9gknd 11051 8 of of IN cord-010119-t1x9gknd 11051 9 JW JW NNP cord-010119-t1x9gknd 11051 10 that that WDT cord-010119-t1x9gknd 11051 11 enter enter VBP cord-010119-t1x9gknd 11051 12 our -PRON- PRP$ cord-010119-t1x9gknd 11051 13 hospital hospital NN cord-010119-t1x9gknd 11051 14 have have VBP cord-010119-t1x9gknd 11051 15 a a DT cord-010119-t1x9gknd 11051 16 DBC DBC NNP cord-010119-t1x9gknd 11051 17 completed complete VBN cord-010119-t1x9gknd 11051 18 . . . cord-010119-t1x9gknd 11052 1 This this DT cord-010119-t1x9gknd 11052 2 has have VBZ cord-010119-t1x9gknd 11052 3 resulted result VBN cord-010119-t1x9gknd 11052 4 in in IN cord-010119-t1x9gknd 11052 5 increased increase VBN cord-010119-t1x9gknd 11052 6 education education NN cord-010119-t1x9gknd 11052 7 of of IN cord-010119-t1x9gknd 11052 8 the the DT cord-010119-t1x9gknd 11052 9 medical medical JJ cord-010119-t1x9gknd 11052 10 staff staff NN cord-010119-t1x9gknd 11052 11 . . . cord-010119-t1x9gknd 11053 1 In in IN cord-010119-t1x9gknd 11053 2 addition addition NN cord-010119-t1x9gknd 11053 3 , , , cord-010119-t1x9gknd 11053 4 patients patient NNS cord-010119-t1x9gknd 11053 5 have have VBP cord-010119-t1x9gknd 11053 6 reported report VBN cord-010119-t1x9gknd 11053 7 better well JJR cord-010119-t1x9gknd 11053 8 communication communication NN cord-010119-t1x9gknd 11053 9 with with IN cord-010119-t1x9gknd 11053 10 caretakers caretaker NNS cord-010119-t1x9gknd 11053 11 leading lead VBG cord-010119-t1x9gknd 11053 12 to to IN cord-010119-t1x9gknd 11053 13 a a DT cord-010119-t1x9gknd 11053 14 more more RBR cord-010119-t1x9gknd 11053 15 inviting inviting JJ cord-010119-t1x9gknd 11053 16 environment environment NN cord-010119-t1x9gknd 11053 17 for for IN cord-010119-t1x9gknd 11053 18 the the DT cord-010119-t1x9gknd 11053 19 patients patient NNS cord-010119-t1x9gknd 11053 20 . . . cord-010119-t1x9gknd 11054 1 Conclusion conclusion NN cord-010119-t1x9gknd 11054 2 : : : cord-010119-t1x9gknd 11055 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11055 2 hospital hospital NN cord-010119-t1x9gknd 11055 3 has have VBZ cord-010119-t1x9gknd 11055 4 found find VBN cord-010119-t1x9gknd 11055 5 success success NN cord-010119-t1x9gknd 11055 6 by by IN cord-010119-t1x9gknd 11055 7 using use VBG cord-010119-t1x9gknd 11055 8 an an DT cord-010119-t1x9gknd 11055 9 education education NN cord-010119-t1x9gknd 11055 10 - - HYPH cord-010119-t1x9gknd 11055 11 based base VBN cord-010119-t1x9gknd 11055 12 team team NN cord-010119-t1x9gknd 11055 13 - - HYPH cord-010119-t1x9gknd 11055 14 oriented orient VBN cord-010119-t1x9gknd 11055 15 approach approach NN cord-010119-t1x9gknd 11055 16 involving involve VBG cord-010119-t1x9gknd 11055 17 EMR EMR NNP cord-010119-t1x9gknd 11055 18 , , , cord-010119-t1x9gknd 11055 19 PBM PBM NNP cord-010119-t1x9gknd 11055 20 , , , cord-010119-t1x9gknd 11055 21 and and CC cord-010119-t1x9gknd 11055 22 caretakers caretaker NNS cord-010119-t1x9gknd 11055 23 when when WRB cord-010119-t1x9gknd 11055 24 caring care VBG cord-010119-t1x9gknd 11055 25 for for IN cord-010119-t1x9gknd 11055 26 the the DT cord-010119-t1x9gknd 11055 27 JW JW NNP cord-010119-t1x9gknd 11055 28 patient patient NN cord-010119-t1x9gknd 11055 29 . . . cord-010119-t1x9gknd 11056 1 This this DT cord-010119-t1x9gknd 11056 2 approach approach NN cord-010119-t1x9gknd 11056 3 has have VBZ cord-010119-t1x9gknd 11056 4 set set VBN cord-010119-t1x9gknd 11056 5 up up RP cord-010119-t1x9gknd 11056 6 a a DT cord-010119-t1x9gknd 11056 7 foundation foundation NN cord-010119-t1x9gknd 11056 8 for for IN cord-010119-t1x9gknd 11056 9 treating treat VBG cord-010119-t1x9gknd 11056 10 other other JJ cord-010119-t1x9gknd 11056 11 bloodless bloodless JJ cord-010119-t1x9gknd 11056 12 medicine medicine NN cord-010119-t1x9gknd 11056 13 patients patient NNS cord-010119-t1x9gknd 11056 14 . . . cord-010119-t1x9gknd 11057 1 Background Background NNP cord-010119-t1x9gknd 11057 2 / / SYM cord-010119-t1x9gknd 11057 3 Case Case NNP cord-010119-t1x9gknd 11057 4 Studies Studies NNPS cord-010119-t1x9gknd 11057 5 : : : cord-010119-t1x9gknd 11058 1 Transfusion transfusion NN cord-010119-t1x9gknd 11058 2 services service NNS cord-010119-t1x9gknd 11058 3 should should MD cord-010119-t1x9gknd 11058 4 provide provide VB cord-010119-t1x9gknd 11058 5 safe safe JJ cord-010119-t1x9gknd 11058 6 blood blood NN cord-010119-t1x9gknd 11058 7 components component NNS cord-010119-t1x9gknd 11058 8 from from IN cord-010119-t1x9gknd 11058 9 vein vein NN cord-010119-t1x9gknd 11058 10 to to IN cord-010119-t1x9gknd 11058 11 vein vein NN cord-010119-t1x9gknd 11058 12 with with IN cord-010119-t1x9gknd 11058 13 donors donor NNS cord-010119-t1x9gknd 11058 14 acting act VBG cord-010119-t1x9gknd 11058 15 as as IN cord-010119-t1x9gknd 11058 16 suppliers supplier NNS cord-010119-t1x9gknd 11058 17 and and CC cord-010119-t1x9gknd 11058 18 patients patient NNS cord-010119-t1x9gknd 11058 19 as as IN cord-010119-t1x9gknd 11058 20 final final JJ cord-010119-t1x9gknd 11058 21 customers customer NNS cord-010119-t1x9gknd 11058 22 . . . cord-010119-t1x9gknd 11059 1 This this DT cord-010119-t1x9gknd 11059 2 process process NN cord-010119-t1x9gknd 11059 3 involves involve VBZ cord-010119-t1x9gknd 11059 4 labor labor NN cord-010119-t1x9gknd 11059 5 - - HYPH cord-010119-t1x9gknd 11059 6 intensive intensive JJ cord-010119-t1x9gknd 11059 7 activities activity NNS cord-010119-t1x9gknd 11059 8 , , , cord-010119-t1x9gknd 11059 9 critical critical JJ cord-010119-t1x9gknd 11059 10 materials material NNS cord-010119-t1x9gknd 11059 11 , , , cord-010119-t1x9gknd 11059 12 human human JJ cord-010119-t1x9gknd 11059 13 resources resource NNS cord-010119-t1x9gknd 11059 14 , , , cord-010119-t1x9gknd 11059 15 facilities facility NNS cord-010119-t1x9gknd 11059 16 and and CC cord-010119-t1x9gknd 11059 17 highly highly RB cord-010119-t1x9gknd 11059 18 coordinated coordinate VBN cord-010119-t1x9gknd 11059 19 processes process NNS cord-010119-t1x9gknd 11059 20 . . . cord-010119-t1x9gknd 11060 1 Cost cost NN cord-010119-t1x9gknd 11060 2 management management NN cord-010119-t1x9gknd 11060 3 has have VBZ cord-010119-t1x9gknd 11060 4 a a DT cord-010119-t1x9gknd 11060 5 great great JJ cord-010119-t1x9gknd 11060 6 impact impact NN cord-010119-t1x9gknd 11060 7 on on IN cord-010119-t1x9gknd 11060 8 technical technical JJ cord-010119-t1x9gknd 11060 9 processes process NNS cord-010119-t1x9gknd 11060 10 guiding guide VBG cord-010119-t1x9gknd 11060 11 decisions decision NNS cord-010119-t1x9gknd 11060 12 upon upon IN cord-010119-t1x9gknd 11060 13 supplies supply NNS cord-010119-t1x9gknd 11060 14 and and CC cord-010119-t1x9gknd 11060 15 technical technical JJ cord-010119-t1x9gknd 11060 16 staff staff NN cord-010119-t1x9gknd 11060 17 . . . cord-010119-t1x9gknd 11061 1 Activity activity NN cord-010119-t1x9gknd 11061 2 - - HYPH cord-010119-t1x9gknd 11061 3 based base VBN cord-010119-t1x9gknd 11061 4 costing costing NN cord-010119-t1x9gknd 11061 5 ( ( -LRB- cord-010119-t1x9gknd 11061 6 ABC ABC NNP cord-010119-t1x9gknd 11061 7 ) ) -RRB- cord-010119-t1x9gknd 11061 8 is be VBZ cord-010119-t1x9gknd 11061 9 a a DT cord-010119-t1x9gknd 11061 10 method method NN cord-010119-t1x9gknd 11061 11 to to TO cord-010119-t1x9gknd 11061 12 determine determine VB cord-010119-t1x9gknd 11061 13 cost cost NN cord-010119-t1x9gknd 11061 14 drivers driver NNS cord-010119-t1x9gknd 11061 15 within within IN cord-010119-t1x9gknd 11061 16 activities activity NNS cord-010119-t1x9gknd 11061 17 and and CC cord-010119-t1x9gknd 11061 18 determine determine VB cord-010119-t1x9gknd 11061 19 process process NN cord-010119-t1x9gknd 11061 20 or or CC cord-010119-t1x9gknd 11061 21 product product NN cord-010119-t1x9gknd 11061 22 final final JJ cord-010119-t1x9gknd 11061 23 cost cost NN cord-010119-t1x9gknd 11061 24 allowing allow VBG cord-010119-t1x9gknd 11061 25 managers manager NNS cord-010119-t1x9gknd 11061 26 to to TO cord-010119-t1x9gknd 11061 27 take take VB cord-010119-t1x9gknd 11061 28 precise precise JJ cord-010119-t1x9gknd 11061 29 decisions decision NNS cord-010119-t1x9gknd 11061 30 . . . cord-010119-t1x9gknd 11062 1 We -PRON- PRP cord-010119-t1x9gknd 11062 2 demonstrate demonstrate VBP cord-010119-t1x9gknd 11062 3 how how WRB cord-010119-t1x9gknd 11062 4 an an DT cord-010119-t1x9gknd 11062 5 effective effective JJ cord-010119-t1x9gknd 11062 6 ABC ABC NNP cord-010119-t1x9gknd 11062 7 approach approach NN cord-010119-t1x9gknd 11062 8 can can MD cord-010119-t1x9gknd 11062 9 result result VB cord-010119-t1x9gknd 11062 10 in in IN cord-010119-t1x9gknd 11062 11 financial financial JJ cord-010119-t1x9gknd 11062 12 savings saving NNS cord-010119-t1x9gknd 11062 13 without without IN cord-010119-t1x9gknd 11062 14 compromising compromise VBG cord-010119-t1x9gknd 11062 15 process process NN cord-010119-t1x9gknd 11062 16 quality quality NN cord-010119-t1x9gknd 11062 17 in in IN cord-010119-t1x9gknd 11062 18 a a DT cord-010119-t1x9gknd 11062 19 mid mid JJ cord-010119-t1x9gknd 11062 20 - - JJ cord-010119-t1x9gknd 11062 21 size size JJ cord-010119-t1x9gknd 11062 22 transfusion transfusion NN cord-010119-t1x9gknd 11062 23 service service NN cord-010119-t1x9gknd 11062 24 . . . cord-010119-t1x9gknd 11063 1 Study Study NNP cord-010119-t1x9gknd 11063 2 Design Design NNP cord-010119-t1x9gknd 11063 3 / / SYM cord-010119-t1x9gknd 11063 4 Method method NN cord-010119-t1x9gknd 11063 5 : : : cord-010119-t1x9gknd 11064 1 Materials material NNS cord-010119-t1x9gknd 11064 2 costs cost NNS cord-010119-t1x9gknd 11064 3 can can MD cord-010119-t1x9gknd 11064 4 represent represent VB cord-010119-t1x9gknd 11064 5 as as RB cord-010119-t1x9gknd 11064 6 far far RB cord-010119-t1x9gknd 11064 7 as as IN cord-010119-t1x9gknd 11064 8 90 90 CD cord-010119-t1x9gknd 11064 9 % % NN cord-010119-t1x9gknd 11064 10 of of IN cord-010119-t1x9gknd 11064 11 an an DT cord-010119-t1x9gknd 11064 12 activity activity NN cord-010119-t1x9gknd 11064 13 . . . cord-010119-t1x9gknd 11065 1 In in IN cord-010119-t1x9gknd 11065 2 2015 2015 CD cord-010119-t1x9gknd 11065 3 we -PRON- PRP cord-010119-t1x9gknd 11065 4 had have VBD cord-010119-t1x9gknd 11065 5 a a DT cord-010119-t1x9gknd 11065 6 central central JJ cord-010119-t1x9gknd 11065 7 storage storage NN cord-010119-t1x9gknd 11065 8 supplying supply VBG cord-010119-t1x9gknd 11065 9 satellite satellite NN cord-010119-t1x9gknd 11065 10 storages storage NNS cord-010119-t1x9gknd 11065 11 at at IN cord-010119-t1x9gknd 11065 12 each each DT cord-010119-t1x9gknd 11065 13 department department NN cord-010119-t1x9gknd 11065 14 and and CC cord-010119-t1x9gknd 11065 15 replacement replacement NN cord-010119-t1x9gknd 11065 16 was be VBD cord-010119-t1x9gknd 11065 17 done do VBN cord-010119-t1x9gknd 11065 18 independent independent NN cord-010119-t1x9gknd 11065 19 of of IN cord-010119-t1x9gknd 11065 20 residual residual JJ cord-010119-t1x9gknd 11065 21 stock stock NN cord-010119-t1x9gknd 11065 22 . . . cord-010119-t1x9gknd 11066 1 Purchases purchase NNS cord-010119-t1x9gknd 11066 2 were be VBD cord-010119-t1x9gknd 11066 3 performed perform VBN cord-010119-t1x9gknd 11066 4 on on IN cord-010119-t1x9gknd 11066 5 demand demand NN cord-010119-t1x9gknd 11066 6 . . . cord-010119-t1x9gknd 11067 1 At at IN cord-010119-t1x9gknd 11067 2 the the DT cord-010119-t1x9gknd 11067 3 end end NN cord-010119-t1x9gknd 11067 4 of of IN cord-010119-t1x9gknd 11067 5 2015 2015 CD cord-010119-t1x9gknd 11067 6 we -PRON- PRP cord-010119-t1x9gknd 11067 7 performed perform VBD cord-010119-t1x9gknd 11067 8 a a DT cord-010119-t1x9gknd 11067 9 supply supply NN cord-010119-t1x9gknd 11067 10 inventory inventory NN cord-010119-t1x9gknd 11067 11 on on IN cord-010119-t1x9gknd 11067 12 all all DT cord-010119-t1x9gknd 11067 13 departments department NNS cord-010119-t1x9gknd 11067 14 to to TO cord-010119-t1x9gknd 11067 15 plan plan VB cord-010119-t1x9gknd 11067 16 future future JJ cord-010119-t1x9gknd 11067 17 purchases purchase NNS cord-010119-t1x9gknd 11067 18 and and CC cord-010119-t1x9gknd 11067 19 control control NN cord-010119-t1x9gknd 11067 20 residual residual JJ cord-010119-t1x9gknd 11067 21 stocks stock NNS cord-010119-t1x9gknd 11067 22 . . . cord-010119-t1x9gknd 11068 1 In in IN cord-010119-t1x9gknd 11068 2 2016 2016 CD cord-010119-t1x9gknd 11068 3 , , , cord-010119-t1x9gknd 11068 4 we -PRON- PRP cord-010119-t1x9gknd 11068 5 implemented implement VBD cord-010119-t1x9gknd 11068 6 annual annual JJ cord-010119-t1x9gknd 11068 7 purchases purchase NNS cord-010119-t1x9gknd 11068 8 and and CC cord-010119-t1x9gknd 11068 9 satellite satellite NN cord-010119-t1x9gknd 11068 10 storages storage NNS cord-010119-t1x9gknd 11068 11 were be VBD cord-010119-t1x9gknd 11068 12 supplied supply VBN cord-010119-t1x9gknd 11068 13 only only RB cord-010119-t1x9gknd 11068 14 to to TO cord-010119-t1x9gknd 11068 15 replenish replenish VB cord-010119-t1x9gknd 11068 16 programmed program VBN cord-010119-t1x9gknd 11068 17 stock stock NN cord-010119-t1x9gknd 11068 18 . . . cord-010119-t1x9gknd 11069 1 Cost cost NN cord-010119-t1x9gknd 11069 2 drivers driver NNS cord-010119-t1x9gknd 11069 3 were be VBD cord-010119-t1x9gknd 11069 4 defined define VBN cord-010119-t1x9gknd 11069 5 upon upon IN cord-010119-t1x9gknd 11069 6 activities activity NNS cord-010119-t1x9gknd 11069 7 on on IN cord-010119-t1x9gknd 11069 8 standard standard JJ cord-010119-t1x9gknd 11069 9 operational operational JJ cord-010119-t1x9gknd 11069 10 procedures procedure NNS cord-010119-t1x9gknd 11069 11 ( ( -LRB- cord-010119-t1x9gknd 11069 12 SOPs sop NNS cord-010119-t1x9gknd 11069 13 ) ) -RRB- cord-010119-t1x9gknd 11069 14 resulting result VBG cord-010119-t1x9gknd 11069 15 in in IN cord-010119-t1x9gknd 11069 16 a a DT cord-010119-t1x9gknd 11069 17 2016 2016 CD cord-010119-t1x9gknd 11069 18 cost cost NN cord-010119-t1x9gknd 11069 19 estimate estimate NN cord-010119-t1x9gknd 11069 20 . . . cord-010119-t1x9gknd 11070 1 Technical technical JJ cord-010119-t1x9gknd 11070 2 staff staff NN cord-010119-t1x9gknd 11070 3 was be VBD cord-010119-t1x9gknd 11070 4 involved involve VBN cord-010119-t1x9gknd 11070 5 in in IN cord-010119-t1x9gknd 11070 6 cost cost NN cord-010119-t1x9gknd 11070 7 driver driver NN cord-010119-t1x9gknd 11070 8 calculations calculation NNS cord-010119-t1x9gknd 11070 9 to to TO cord-010119-t1x9gknd 11070 10 indicate indicate VB cord-010119-t1x9gknd 11070 11 possible possible JJ cord-010119-t1x9gknd 11070 12 changes change NNS cord-010119-t1x9gknd 11070 13 to to IN cord-010119-t1x9gknd 11070 14 SOPs sop NNS cord-010119-t1x9gknd 11070 15 , , , cord-010119-t1x9gknd 11070 16 supplier supplier NN cord-010119-t1x9gknd 11070 17 and and CC cord-010119-t1x9gknd 11070 18 deliveries delivery NNS cord-010119-t1x9gknd 11070 19 . . . cord-010119-t1x9gknd 11071 1 To to TO cord-010119-t1x9gknd 11071 2 minimize minimize VB cord-010119-t1x9gknd 11071 3 seasonal seasonal JJ cord-010119-t1x9gknd 11071 4 fluctuations fluctuation NNS cord-010119-t1x9gknd 11071 5 we -PRON- PRP cord-010119-t1x9gknd 11071 6 compared compare VBN cord-010119-t1x9gknd 11071 7 last last JJ cord-010119-t1x9gknd 11071 8 quarter quarter NN cord-010119-t1x9gknd 11071 9 2015 2015 CD cord-010119-t1x9gknd 11072 1 ( ( -LRB- cord-010119-t1x9gknd 11072 2 Q4/15 Q4/15 NNP cord-010119-t1x9gknd 11072 3 ) ) -RRB- cord-010119-t1x9gknd 11072 4 with with IN cord-010119-t1x9gknd 11072 5 last last JJ cord-010119-t1x9gknd 11072 6 quarter quarter NN cord-010119-t1x9gknd 11072 7 2016 2016 CD cord-010119-t1x9gknd 11073 1 ( ( -LRB- cord-010119-t1x9gknd 11073 2 Q4/16 Q4/16 NNP cord-010119-t1x9gknd 11073 3 ) ) -RRB- cord-010119-t1x9gknd 11073 4 . . . cord-010119-t1x9gknd 11074 1 In in IN cord-010119-t1x9gknd 11074 2 this this DT cord-010119-t1x9gknd 11074 3 work work NN cord-010119-t1x9gknd 11074 4 we -PRON- PRP cord-010119-t1x9gknd 11074 5 present present VBP cord-010119-t1x9gknd 11074 6 activity activity NN cord-010119-t1x9gknd 11074 7 data datum NNS cord-010119-t1x9gknd 11074 8 from from IN cord-010119-t1x9gknd 11074 9 blood blood NN cord-010119-t1x9gknd 11074 10 collections collection NNS cord-010119-t1x9gknd 11074 11 to to TO cord-010119-t1x9gknd 11074 12 illustrate illustrate VB cord-010119-t1x9gknd 11074 13 ABC ABC NNP cord-010119-t1x9gknd 11074 14 method method NN cord-010119-t1x9gknd 11074 15 . . . cord-010119-t1x9gknd 11075 1 Results result NNS cord-010119-t1x9gknd 11075 2 / / SYM cord-010119-t1x9gknd 11075 3 Finding finding NN cord-010119-t1x9gknd 11075 4 : : : cord-010119-t1x9gknd 11076 1 In in IN cord-010119-t1x9gknd 11076 2 Q4/15 Q4/15 NNP cord-010119-t1x9gknd 11076 3 1756 1756 CD cord-010119-t1x9gknd 11076 4 blood blood NN cord-010119-t1x9gknd 11076 5 bags bag NNS cord-010119-t1x9gknd 11076 6 were be VBD cord-010119-t1x9gknd 11076 7 used use VBN cord-010119-t1x9gknd 11076 8 compared compare VBN cord-010119-t1x9gknd 11076 9 to to IN cord-010119-t1x9gknd 11076 10 1998 1998 CD cord-010119-t1x9gknd 11076 11 in in IN cord-010119-t1x9gknd 11076 12 Q4/16 Q4/16 NNP cord-010119-t1x9gknd 11076 13 , , , cord-010119-t1x9gknd 11076 14 demonstrating demonstrate VBG cord-010119-t1x9gknd 11076 15 an an DT cord-010119-t1x9gknd 11076 16 activity activity NN cord-010119-t1x9gknd 11076 17 " " '' cord-010119-t1x9gknd 11076 18 13.78 13.78 CD cord-010119-t1x9gknd 11076 19 % % NN cord-010119-t1x9gknd 11076 20 . . . cord-010119-t1x9gknd 11077 1 Price price NN cord-010119-t1x9gknd 11077 2 negotiation negotiation NN cord-010119-t1x9gknd 11077 3 resulted result VBD cord-010119-t1x9gknd 11077 4 in in IN cord-010119-t1x9gknd 11077 5 12.58 12.58 CD cord-010119-t1x9gknd 11077 6 % % NN cord-010119-t1x9gknd 11077 7 readjustment readjustment NN cord-010119-t1x9gknd 11077 8 . . . cord-010119-t1x9gknd 11078 1 Both both DT cord-010119-t1x9gknd 11078 2 indicated indicate VBD cord-010119-t1x9gknd 11078 3 an an DT cord-010119-t1x9gknd 11078 4 estimated estimate VBN cord-010119-t1x9gknd 11078 5 cost cost NN cord-010119-t1x9gknd 11078 6 " " '' cord-010119-t1x9gknd 11078 7 28.10 28.10 CD cord-010119-t1x9gknd 11078 8 % % NN cord-010119-t1x9gknd 11078 9 with with IN cord-010119-t1x9gknd 11078 10 a a DT cord-010119-t1x9gknd 11078 11 possible possible JJ cord-010119-t1x9gknd 11078 12 impact impact NN cord-010119-t1x9gknd 11078 13 of of IN cord-010119-t1x9gknd 11078 14 over over IN cord-010119-t1x9gknd 11078 15 US$ us$ $ cord-010119-t1x9gknd 11078 16 35,000 35,000 CD cord-010119-t1x9gknd 11078 17 . . . cord-010119-t1x9gknd 11079 1 We -PRON- PRP cord-010119-t1x9gknd 11079 2 have have VBP cord-010119-t1x9gknd 11079 3 identified identify VBN cord-010119-t1x9gknd 11079 4 a a DT cord-010119-t1x9gknd 11079 5 real real JJ cord-010119-t1x9gknd 11079 6 cost cost NN cord-010119-t1x9gknd 11079 7 # # $ cord-010119-t1x9gknd 11079 8 2.31 2.31 CD cord-010119-t1x9gknd 11079 9 % % NN cord-010119-t1x9gknd 11079 10 in in IN cord-010119-t1x9gknd 11079 11 Q4/16 Q4/16 NNP cord-010119-t1x9gknd 11079 12 , , , cord-010119-t1x9gknd 11079 13 representing represent VBG cord-010119-t1x9gknd 11079 14 an an DT cord-010119-t1x9gknd 11079 15 overall overall JJ cord-010119-t1x9gknd 11079 16 # # $ cord-010119-t1x9gknd 11079 17 14.89 14.89 CD cord-010119-t1x9gknd 11079 18 % % NN cord-010119-t1x9gknd 11079 19 and and CC cord-010119-t1x9gknd 11079 20 US$ us$ $ cord-010119-t1x9gknd 11079 21 3,716.72 3,716.72 CD cord-010119-t1x9gknd 11079 22 ( ( -LRB- cord-010119-t1x9gknd 11079 23 R$12,235.16 R$12,235.16 NNP cord-010119-t1x9gknd 11079 24 ) ) -RRB- cord-010119-t1x9gknd 11079 25 savings saving NNS cord-010119-t1x9gknd 11079 26 . . . cord-010119-t1x9gknd 11080 1 Conclusion conclusion NN cord-010119-t1x9gknd 11080 2 : : : cord-010119-t1x9gknd 11081 1 Economy economy NN cord-010119-t1x9gknd 11081 2 had have VBD cord-010119-t1x9gknd 11081 3 deteriorated deteriorate VBN cord-010119-t1x9gknd 11081 4 in in IN cord-010119-t1x9gknd 11081 5 our -PRON- PRP$ cord-010119-t1x9gknd 11081 6 country country NN cord-010119-t1x9gknd 11081 7 in in IN cord-010119-t1x9gknd 11081 8 2016 2016 CD cord-010119-t1x9gknd 11081 9 with with IN cord-010119-t1x9gknd 11081 10 higher high JJR cord-010119-t1x9gknd 11081 11 inflation inflation NN cord-010119-t1x9gknd 11081 12 and and CC cord-010119-t1x9gknd 11081 13 exchange exchange NN cord-010119-t1x9gknd 11081 14 rate rate NN cord-010119-t1x9gknd 11081 15 variations variation NNS cord-010119-t1x9gknd 11081 16 , , , cord-010119-t1x9gknd 11081 17 directly directly RB cord-010119-t1x9gknd 11081 18 impacting impact VBG cord-010119-t1x9gknd 11081 19 imported import VBN cord-010119-t1x9gknd 11081 20 materials material NNS cord-010119-t1x9gknd 11081 21 , , , cord-010119-t1x9gknd 11081 22 most most JJS cord-010119-t1x9gknd 11081 23 of of IN cord-010119-t1x9gknd 11081 24 them -PRON- PRP cord-010119-t1x9gknd 11081 25 critical critical JJ cord-010119-t1x9gknd 11081 26 . . . cord-010119-t1x9gknd 11082 1 Even even RB cord-010119-t1x9gknd 11082 2 with with IN cord-010119-t1x9gknd 11082 3 adverse adverse JJ cord-010119-t1x9gknd 11082 4 economy economy NN cord-010119-t1x9gknd 11082 5 , , , cord-010119-t1x9gknd 11082 6 ABC ABC NNP cord-010119-t1x9gknd 11082 7 showed show VBD cord-010119-t1x9gknd 11082 8 to to TO cord-010119-t1x9gknd 11082 9 be be VB cord-010119-t1x9gknd 11082 10 an an DT cord-010119-t1x9gknd 11082 11 effective effective JJ cord-010119-t1x9gknd 11082 12 tool tool NN cord-010119-t1x9gknd 11082 13 that that WDT cord-010119-t1x9gknd 11082 14 allowed allow VBD cord-010119-t1x9gknd 11082 15 cost cost NN cord-010119-t1x9gknd 11082 16 decrease decrease NN cord-010119-t1x9gknd 11082 17 without without IN cord-010119-t1x9gknd 11082 18 significant significant JJ cord-010119-t1x9gknd 11082 19 changes change NNS cord-010119-t1x9gknd 11082 20 in in IN cord-010119-t1x9gknd 11082 21 critical critical JJ cord-010119-t1x9gknd 11082 22 materials material NNS cord-010119-t1x9gknd 11082 23 and and CC cord-010119-t1x9gknd 11082 24 processes process NNS cord-010119-t1x9gknd 11082 25 . . . cord-010119-t1x9gknd 11083 1 Cost cost NN cord-010119-t1x9gknd 11083 2 drivers driver NNS cord-010119-t1x9gknd 11083 3 calculations calculation NNS cord-010119-t1x9gknd 11083 4 demanded demand VBD cord-010119-t1x9gknd 11083 5 review review NN cord-010119-t1x9gknd 11083 6 of of IN cord-010119-t1x9gknd 11083 7 SOPs sop NNS cord-010119-t1x9gknd 11083 8 and and CC cord-010119-t1x9gknd 11083 9 suppliers supplier NNS cord-010119-t1x9gknd 11083 10 by by IN cord-010119-t1x9gknd 11083 11 technical technical JJ cord-010119-t1x9gknd 11083 12 staff staff NN cord-010119-t1x9gknd 11083 13 resulting result VBG cord-010119-t1x9gknd 11083 14 in in IN cord-010119-t1x9gknd 11083 15 optimization optimization NN cord-010119-t1x9gknd 11083 16 of of IN cord-010119-t1x9gknd 11083 17 activities activity NNS cord-010119-t1x9gknd 11083 18 . . . cord-010119-t1x9gknd 11084 1 Also also RB cord-010119-t1x9gknd 11084 2 , , , cord-010119-t1x9gknd 11084 3 staff staff NN cord-010119-t1x9gknd 11084 4 involvement involvement NN cord-010119-t1x9gknd 11084 5 reduced reduce VBD cord-010119-t1x9gknd 11084 6 discharged discharge VBN cord-010119-t1x9gknd 11084 7 materials material NNS cord-010119-t1x9gknd 11084 8 since since IN cord-010119-t1x9gknd 11084 9 costs cost NNS cord-010119-t1x9gknd 11084 10 were be VBD cord-010119-t1x9gknd 11084 11 wellknown wellknown JJ cord-010119-t1x9gknd 11084 12 to to IN cord-010119-t1x9gknd 11084 13 area area NN cord-010119-t1x9gknd 11084 14 supervisors supervisor NNS cord-010119-t1x9gknd 11084 15 and and CC cord-010119-t1x9gknd 11084 16 satellite satellite NN cord-010119-t1x9gknd 11084 17 stocks stock NNS cord-010119-t1x9gknd 11084 18 were be VBD cord-010119-t1x9gknd 11084 19 reviewed review VBN cord-010119-t1x9gknd 11084 20 briefly briefly RB cord-010119-t1x9gknd 11084 21 . . . cord-010119-t1x9gknd 11085 1 Automated automated JJ cord-010119-t1x9gknd 11085 2 Verification verification NN cord-010119-t1x9gknd 11085 3 of of IN cord-010119-t1x9gknd 11085 4 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 11085 5 Results Results NNPS cord-010119-t1x9gknd 11085 6 and and CC cord-010119-t1x9gknd 11085 7 the the DT cord-010119-t1x9gknd 11085 8 Impact Impact NNP cord-010119-t1x9gknd 11085 9 to to IN cord-010119-t1x9gknd 11085 10 Donor Donor NNP cord-010119-t1x9gknd 11085 11 Testing Testing NNP cord-010119-t1x9gknd 11085 12 Barbara Barbara NNP cord-010119-t1x9gknd 11085 13 J J NNP cord-010119-t1x9gknd 11085 14 Bachman Bachman NNP cord-010119-t1x9gknd 11086 1 * * NFP cord-010119-t1x9gknd 11086 2 1 1 CD cord-010119-t1x9gknd 11086 3 , , , cord-010119-t1x9gknd 11086 4 Candace Candace NNP cord-010119-t1x9gknd 11086 5 Williams Williams NNP cord-010119-t1x9gknd 11086 6 1 1 CD cord-010119-t1x9gknd 11086 7 , , , cord-010119-t1x9gknd 11086 8 Carmen Carmen NNP cord-010119-t1x9gknd 11086 9 Meyer Meyer NNP cord-010119-t1x9gknd 11086 10 2 2 CD cord-010119-t1x9gknd 11086 11 , , , cord-010119-t1x9gknd 11086 12 Paul Paul NNP cord-010119-t1x9gknd 11086 13 Lamonby Lamonby NNP cord-010119-t1x9gknd 11086 14 1 1 CD cord-010119-t1x9gknd 11086 15 , , , cord-010119-t1x9gknd 11086 16 Anne Anne NNP cord-010119-t1x9gknd 11086 17 Cleverley Cleverley NNP cord-010119-t1x9gknd 11086 18 1 1 CD cord-010119-t1x9gknd 11086 19 and and CC cord-010119-t1x9gknd 11086 20 Silke Silke NNP cord-010119-t1x9gknd 11086 21 Milbradt Milbradt NNP cord-010119-t1x9gknd 11086 22 - - HYPH cord-010119-t1x9gknd 11086 23 Pohan Pohan NNP cord-010119-t1x9gknd 11086 24 1 1 CD cord-010119-t1x9gknd 11086 25 . . . cord-010119-t1x9gknd 11087 1 1 1 CD cord-010119-t1x9gknd 11087 2 Bio Bio NNP cord-010119-t1x9gknd 11087 3 - - HYPH cord-010119-t1x9gknd 11087 4 Rad Rad NNP cord-010119-t1x9gknd 11087 5 Laboratories Laboratories NNP cord-010119-t1x9gknd 11087 6 , , , cord-010119-t1x9gknd 11087 7 2 2 CD cord-010119-t1x9gknd 11087 8 Diamed Diamed NNP cord-010119-t1x9gknd 11087 9 Gmbh Gmbh NNP cord-010119-t1x9gknd 11088 1 Title title NN cord-010119-t1x9gknd 11088 2 : : : cord-010119-t1x9gknd 11088 3 Automated automated JJ cord-010119-t1x9gknd 11088 4 Verification verification NN cord-010119-t1x9gknd 11088 5 of of IN cord-010119-t1x9gknd 11088 6 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 11088 7 Results Results NNPS cord-010119-t1x9gknd 11088 8 and and CC cord-010119-t1x9gknd 11088 9 the the DT cord-010119-t1x9gknd 11088 10 Impact Impact NNP cord-010119-t1x9gknd 11088 11 to to IN cord-010119-t1x9gknd 11088 12 Donor Donor NNP cord-010119-t1x9gknd 11088 13 Testing Testing NNP cord-010119-t1x9gknd 11088 14 Background Background NNP cord-010119-t1x9gknd 11088 15 / / SYM cord-010119-t1x9gknd 11088 16 Case Case NNP cord-010119-t1x9gknd 11088 17 Studies Studies NNPS cord-010119-t1x9gknd 11088 18 : : : cord-010119-t1x9gknd 11088 19 Staffing staffing NN cord-010119-t1x9gknd 11088 20 challenges challenge NNS cord-010119-t1x9gknd 11088 21 in in IN cord-010119-t1x9gknd 11088 22 today today NN cord-010119-t1x9gknd 11088 23 's 's POS cord-010119-t1x9gknd 11088 24 blood blood NN cord-010119-t1x9gknd 11088 25 banks bank NNS cord-010119-t1x9gknd 11088 26 require require VBP cord-010119-t1x9gknd 11088 27 instrumentation instrumentation NN cord-010119-t1x9gknd 11088 28 with with IN cord-010119-t1x9gknd 11088 29 minimal minimal JJ cord-010119-t1x9gknd 11088 30 operator operator NN cord-010119-t1x9gknd 11088 31 intervention intervention NN cord-010119-t1x9gknd 11088 32 . . . cord-010119-t1x9gknd 11089 1 Technology technology NN cord-010119-t1x9gknd 11089 2 advances advance NNS cord-010119-t1x9gknd 11089 3 have have VBP cord-010119-t1x9gknd 11089 4 developed develop VBN cord-010119-t1x9gknd 11089 5 where where WRB cord-010119-t1x9gknd 11089 6 every every DT cord-010119-t1x9gknd 11089 7 immunohematology immunohematology NN cord-010119-t1x9gknd 11089 8 result result NN cord-010119-t1x9gknd 11089 9 does do VBZ cord-010119-t1x9gknd 11089 10 not not RB cord-010119-t1x9gknd 11089 11 necessarily necessarily RB cord-010119-t1x9gknd 11089 12 require require VB cord-010119-t1x9gknd 11089 13 operator operator NN cord-010119-t1x9gknd 11089 14 visual visual JJ cord-010119-t1x9gknd 11089 15 review review NN cord-010119-t1x9gknd 11089 16 . . . cord-010119-t1x9gknd 11090 1 This this DT cord-010119-t1x9gknd 11090 2 study study NN cord-010119-t1x9gknd 11090 3 evaluates evaluate VBZ cord-010119-t1x9gknd 11090 4 the the DT cord-010119-t1x9gknd 11090 5 impact impact NN cord-010119-t1x9gknd 11090 6 of of IN cord-010119-t1x9gknd 11090 7 automated automated JJ cord-010119-t1x9gknd 11090 8 result result NN cord-010119-t1x9gknd 11090 9 verification verification NN cord-010119-t1x9gknd 11090 10 on on IN cord-010119-t1x9gknd 11090 11 the the DT cord-010119-t1x9gknd 11090 12 Bio Bio NNP cord-010119-t1x9gknd 11090 13 - - HYPH cord-010119-t1x9gknd 11090 14 Rad Rad NNP cord-010119-t1x9gknd 11090 15 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11090 16 TM TM NNP cord-010119-t1x9gknd 11090 17 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 11090 18 System System NNP cord-010119-t1x9gknd 11090 19 through through IN cord-010119-t1x9gknd 11090 20 the the DT cord-010119-t1x9gknd 11090 21 IH IH NNP cord-010119-t1x9gknd 11090 22 - - HYPH cord-010119-t1x9gknd 11090 23 Com Com NNP cord-010119-t1x9gknd 11090 24 TM TM NNP cord-010119-t1x9gknd 11090 25 Data Data NNP cord-010119-t1x9gknd 11090 26 Management Management NNP cord-010119-t1x9gknd 11090 27 System System NNP cord-010119-t1x9gknd 11090 28 ( ( -LRB- cord-010119-t1x9gknd 11090 29 DMS DMS NNP cord-010119-t1x9gknd 11090 30 ) ) -RRB- cord-010119-t1x9gknd 11090 31 for for IN cord-010119-t1x9gknd 11090 32 donor donor NN cord-010119-t1x9gknd 11090 33 processing processing NN cord-010119-t1x9gknd 11090 34 laboratories laboratory NNS cord-010119-t1x9gknd 11090 35 . . . cord-010119-t1x9gknd 11091 1 Study Study NNP cord-010119-t1x9gknd 11091 2 Design Design NNP cord-010119-t1x9gknd 11091 3 / / SYM cord-010119-t1x9gknd 11091 4 Method method NN cord-010119-t1x9gknd 11091 5 : : : cord-010119-t1x9gknd 11092 1 A a DT cord-010119-t1x9gknd 11092 2 multi multi JJ cord-010119-t1x9gknd 11092 3 - - JJ cord-010119-t1x9gknd 11092 4 center center JJ cord-010119-t1x9gknd 11092 5 study study NN cord-010119-t1x9gknd 11092 6 was be VBD cord-010119-t1x9gknd 11092 7 performed perform VBN cord-010119-t1x9gknd 11092 8 on on IN cord-010119-t1x9gknd 11092 9 donor donor NN cord-010119-t1x9gknd 11092 10 samples sample NNS cord-010119-t1x9gknd 11092 11 as as IN cord-010119-t1x9gknd 11092 12 shown show VBN cord-010119-t1x9gknd 11092 13 in in IN cord-010119-t1x9gknd 11093 1 Table table NN cord-010119-t1x9gknd 11093 2 A a DT cord-010119-t1x9gknd 11093 3 evaluating evaluate VBG cord-010119-t1x9gknd 11093 4 two two CD cord-010119-t1x9gknd 11093 5 of of IN cord-010119-t1x9gknd 11093 6 the the DT cord-010119-t1x9gknd 11093 7 most most RBS cord-010119-t1x9gknd 11093 8 commonly commonly RB cord-010119-t1x9gknd 11093 9 used use VBN cord-010119-t1x9gknd 11093 10 IH IH NNP cord-010119-t1x9gknd 11093 11 - - HYPH cord-010119-t1x9gknd 11093 12 System System NNP cord-010119-t1x9gknd 11093 13 Gel Gel NNP cord-010119-t1x9gknd 11093 14 Cards card NNS cord-010119-t1x9gknd 11093 15 available available JJ cord-010119-t1x9gknd 11093 16 in in IN cord-010119-t1x9gknd 11093 17 the the DT cord-010119-t1x9gknd 11093 18 US US NNP cord-010119-t1x9gknd 11093 19 . . . cord-010119-t1x9gknd 11094 1 Workflow workflow NN cord-010119-t1x9gknd 11094 2 data datum NNS cord-010119-t1x9gknd 11094 3 was be VBD cord-010119-t1x9gknd 11094 4 analyzed analyze VBN cord-010119-t1x9gknd 11094 5 using use VBG cord-010119-t1x9gknd 11094 6 Process Process NNP cord-010119-t1x9gknd 11094 7 Modellar Modellar NNP cord-010119-t1x9gknd 11094 8 APP app NN cord-010119-t1x9gknd 11094 9 ( ( -LRB- cord-010119-t1x9gknd 11094 10 iPad iPad NNP cord-010119-t1x9gknd 11094 11 ) ) -RRB- cord-010119-t1x9gknd 11094 12 . . . cord-010119-t1x9gknd 11095 1 This this DT cord-010119-t1x9gknd 11095 2 study study NN cord-010119-t1x9gknd 11095 3 focused focus VBD cord-010119-t1x9gknd 11095 4 on on IN cord-010119-t1x9gknd 11095 5 post post JJ cord-010119-t1x9gknd 11095 6 - - JJ cord-010119-t1x9gknd 11095 7 analytical analytical JJ cord-010119-t1x9gknd 11095 8 steps step NNS cord-010119-t1x9gknd 11095 9 of of IN cord-010119-t1x9gknd 11095 10 result result NN cord-010119-t1x9gknd 11095 11 verification verification NN cord-010119-t1x9gknd 11095 12 , , , cord-010119-t1x9gknd 11095 13 evaluating evaluate VBG cord-010119-t1x9gknd 11095 14 with with IN cord-010119-t1x9gknd 11095 15 and and CC cord-010119-t1x9gknd 11095 16 without without IN cord-010119-t1x9gknd 11095 17 automated automated JJ cord-010119-t1x9gknd 11095 18 result result NN cord-010119-t1x9gknd 11095 19 verification verification NN cord-010119-t1x9gknd 11095 20 to to TO cord-010119-t1x9gknd 11095 21 determine determine VB cord-010119-t1x9gknd 11095 22 the the DT cord-010119-t1x9gknd 11095 23 impact impact NN cord-010119-t1x9gknd 11095 24 on on IN cord-010119-t1x9gknd 11095 25 quality quality NN cord-010119-t1x9gknd 11095 26 ( ( -LRB- cord-010119-t1x9gknd 11095 27 # # $ cord-010119-t1x9gknd 11095 28 operator operator NN cord-010119-t1x9gknd 11095 29 touchpoints touchpoint NNS cord-010119-t1x9gknd 11095 30 , , , cord-010119-t1x9gknd 11095 31 visual visual JJ cord-010119-t1x9gknd 11095 32 result result NN cord-010119-t1x9gknd 11095 33 review review NN cord-010119-t1x9gknd 11095 34 occurrence occurrence NN cord-010119-t1x9gknd 11095 35 ) ) -RRB- cord-010119-t1x9gknd 11095 36 , , , cord-010119-t1x9gknd 11095 37 result result NN cord-010119-t1x9gknd 11095 38 accuracy accuracy NN cord-010119-t1x9gknd 11095 39 , , , cord-010119-t1x9gknd 11095 40 and and CC cord-010119-t1x9gknd 11095 41 speed speed NN cord-010119-t1x9gknd 11095 42 ( ( -LRB- cord-010119-t1x9gknd 11095 43 time time NN cord-010119-t1x9gknd 11095 44 from from IN cord-010119-t1x9gknd 11095 45 result result JJ cord-010119-t1x9gknd 11095 46 interpretation interpretation NN cord-010119-t1x9gknd 11095 47 to to IN cord-010119-t1x9gknd 11095 48 LIS LIS NNP cord-010119-t1x9gknd 11095 49 data datum NNS cord-010119-t1x9gknd 11095 50 transfer transfer NN cord-010119-t1x9gknd 11095 51 ) ) -RRB- cord-010119-t1x9gknd 11095 52 . . . cord-010119-t1x9gknd 11096 1 Operator operator NN cord-010119-t1x9gknd 11096 2 touchpoints touchpoint NNS cord-010119-t1x9gknd 11096 3 during during IN cord-010119-t1x9gknd 11096 4 the the DT cord-010119-t1x9gknd 11096 5 post post JJ cord-010119-t1x9gknd 11096 6 - - JJ cord-010119-t1x9gknd 11096 7 analytical analytical JJ cord-010119-t1x9gknd 11096 8 phase phase NN cord-010119-t1x9gknd 11096 9 are be VBP cord-010119-t1x9gknd 11096 10 only only RB cord-010119-t1x9gknd 11096 11 required require VBN cord-010119-t1x9gknd 11096 12 when when WRB cord-010119-t1x9gknd 11096 13 doing do VBG cord-010119-t1x9gknd 11096 14 visual visual JJ cord-010119-t1x9gknd 11096 15 result result NN cord-010119-t1x9gknd 11096 16 verification verification NN cord-010119-t1x9gknd 11096 17 and and CC cord-010119-t1x9gknd 11096 18 are be VBP cord-010119-t1x9gknd 11096 19 software software NN cord-010119-t1x9gknd 11096 20 defined define VBN cord-010119-t1x9gknd 11096 21 . . . cord-010119-t1x9gknd 11097 1 Speed speed NN cord-010119-t1x9gknd 11097 2 metrics metric NNS cord-010119-t1x9gknd 11097 3 were be VBD cord-010119-t1x9gknd 11097 4 analyzed analyze VBN cord-010119-t1x9gknd 11097 5 using use VBG cord-010119-t1x9gknd 11097 6 Minitab Minitab NNP cord-010119-t1x9gknd 11097 7 v17 v17 NNP cord-010119-t1x9gknd 11097 8 , , , cord-010119-t1x9gknd 11097 9 statistical statistical JJ cord-010119-t1x9gknd 11097 10 The the DT cord-010119-t1x9gknd 11097 11 transfusion transfusion NN cord-010119-t1x9gknd 11097 12 team team NN cord-010119-t1x9gknd 11097 13 collaborated collaborate VBN cord-010119-t1x9gknd 11097 14 with with IN cord-010119-t1x9gknd 11097 15 multiple multiple JJ cord-010119-t1x9gknd 11097 16 user user NN cord-010119-t1x9gknd 11097 17 groups group NNS cord-010119-t1x9gknd 11097 18 to to TO cord-010119-t1x9gknd 11097 19 educate educate VB cord-010119-t1x9gknd 11097 20 them -PRON- PRP cord-010119-t1x9gknd 11097 21 regarding regard VBG cord-010119-t1x9gknd 11097 22 the the DT cord-010119-t1x9gknd 11097 23 new new JJ cord-010119-t1x9gknd 11097 24 processes process NNS cord-010119-t1x9gknd 11097 25 . . . cord-010119-t1x9gknd 11098 1 A a DT cord-010119-t1x9gknd 11098 2 gap gap NN cord-010119-t1x9gknd 11098 3 analysis analysis NN cord-010119-t1x9gknd 11098 4 was be VBD cord-010119-t1x9gknd 11098 5 performed perform VBN cord-010119-t1x9gknd 11098 6 to to TO cord-010119-t1x9gknd 11098 7 determine determine VB cord-010119-t1x9gknd 11098 8 the the DT cord-010119-t1x9gknd 11098 9 optimal optimal JJ cord-010119-t1x9gknd 11098 10 delivery delivery NN cord-010119-t1x9gknd 11098 11 process process NN cord-010119-t1x9gknd 11098 12 for for IN cord-010119-t1x9gknd 11098 13 blood blood NN cord-010119-t1x9gknd 11098 14 products product NNS cord-010119-t1x9gknd 11098 15 , , , cord-010119-t1x9gknd 11098 16 with with IN cord-010119-t1x9gknd 11098 17 key key JJ cord-010119-t1x9gknd 11098 18 stakeholders stakeholder NNS cord-010119-t1x9gknd 11098 19 invited invite VBN cord-010119-t1x9gknd 11098 20 to to TO cord-010119-t1x9gknd 11098 21 review review VB cord-010119-t1x9gknd 11098 22 the the DT cord-010119-t1x9gknd 11098 23 options option NNS cord-010119-t1x9gknd 11098 24 . . . cord-010119-t1x9gknd 11099 1 The the DT cord-010119-t1x9gknd 11099 2 use use NN cord-010119-t1x9gknd 11099 3 of of IN cord-010119-t1x9gknd 11099 4 the the DT cord-010119-t1x9gknd 11099 5 pneumatic pneumatic JJ cord-010119-t1x9gknd 11099 6 tube tube NN cord-010119-t1x9gknd 11099 7 system system NN cord-010119-t1x9gknd 11099 8 to to TO cord-010119-t1x9gknd 11099 9 deliver deliver VB cord-010119-t1x9gknd 11099 10 blood blood NN cord-010119-t1x9gknd 11099 11 throughout throughout IN cord-010119-t1x9gknd 11099 12 the the DT cord-010119-t1x9gknd 11099 13 entire entire JJ cord-010119-t1x9gknd 11099 14 campus campus NN cord-010119-t1x9gknd 11099 15 was be VBD cord-010119-t1x9gknd 11099 16 investigated investigate VBN cord-010119-t1x9gknd 11099 17 to to TO cord-010119-t1x9gknd 11099 18 determine determine VB cord-010119-t1x9gknd 11099 19 whether whether IN cord-010119-t1x9gknd 11099 20 it -PRON- PRP cord-010119-t1x9gknd 11099 21 would would MD cord-010119-t1x9gknd 11099 22 be be VB cord-010119-t1x9gknd 11099 23 a a DT cord-010119-t1x9gknd 11099 24 viable viable JJ cord-010119-t1x9gknd 11099 25 option option NN cord-010119-t1x9gknd 11099 26 given give VBN cord-010119-t1x9gknd 11099 27 the the DT cord-010119-t1x9gknd 11099 28 expanded expand VBN cord-010119-t1x9gknd 11099 29 size size NN cord-010119-t1x9gknd 11099 30 of of IN cord-010119-t1x9gknd 11099 31 the the DT cord-010119-t1x9gknd 11099 32 new new JJ cord-010119-t1x9gknd 11099 33 campus campus NN cord-010119-t1x9gknd 11099 34 . . . cord-010119-t1x9gknd 11100 1 Results/ Results/ . cord-010119-t1x9gknd 11101 1 Finding finding NN cord-010119-t1x9gknd 11101 2 : : : cord-010119-t1x9gknd 11102 1 User user NN cord-010119-t1x9gknd 11102 2 groups group NNS cord-010119-t1x9gknd 11102 3 requested request VBD cord-010119-t1x9gknd 11102 4 additional additional JJ cord-010119-t1x9gknd 11102 5 training training NN cord-010119-t1x9gknd 11102 6 sessions session NNS cord-010119-t1x9gknd 11102 7 as as IN cord-010119-t1x9gknd 11102 8 questions question NNS cord-010119-t1x9gknd 11102 9 arose arise VBD cord-010119-t1x9gknd 11102 10 regarding regard VBG cord-010119-t1x9gknd 11102 11 use use NN cord-010119-t1x9gknd 11102 12 of of IN cord-010119-t1x9gknd 11102 13 the the DT cord-010119-t1x9gknd 11102 14 eHR eHR NNS cord-010119-t1x9gknd 11102 15 for for IN cord-010119-t1x9gknd 11102 16 blood blood NN cord-010119-t1x9gknd 11102 17 ordering ordering NN cord-010119-t1x9gknd 11102 18 . . . cord-010119-t1x9gknd 11103 1 Because because IN cord-010119-t1x9gknd 11103 2 the the DT cord-010119-t1x9gknd 11103 3 pneumatic pneumatic JJ cord-010119-t1x9gknd 11103 4 tube tube NN cord-010119-t1x9gknd 11103 5 system system NN cord-010119-t1x9gknd 11103 6 would would MD cord-010119-t1x9gknd 11103 7 be be VB cord-010119-t1x9gknd 11103 8 heavily heavily RB cord-010119-t1x9gknd 11103 9 used use VBN cord-010119-t1x9gknd 11103 10 , , , cord-010119-t1x9gknd 11103 11 and and CC cord-010119-t1x9gknd 11103 12 due due IN cord-010119-t1x9gknd 11103 13 to to IN cord-010119-t1x9gknd 11103 14 concerns concern NNS cord-010119-t1x9gknd 11103 15 that that IN cord-010119-t1x9gknd 11103 16 blood blood NN cord-010119-t1x9gknd 11103 17 products product NNS cord-010119-t1x9gknd 11103 18 could could MD cord-010119-t1x9gknd 11103 19 become become VB cord-010119-t1x9gknd 11103 20 " " `` cord-010119-t1x9gknd 11103 21 lost lose VBN cord-010119-t1x9gknd 11103 22 " " '' cord-010119-t1x9gknd 11103 23 , , , cord-010119-t1x9gknd 11103 24 it -PRON- PRP cord-010119-t1x9gknd 11103 25 was be VBD cord-010119-t1x9gknd 11103 26 decided decide VBN cord-010119-t1x9gknd 11103 27 this this DT cord-010119-t1x9gknd 11103 28 would would MD cord-010119-t1x9gknd 11103 29 not not RB cord-010119-t1x9gknd 11103 30 be be VB cord-010119-t1x9gknd 11103 31 the the DT cord-010119-t1x9gknd 11103 32 best good JJS cord-010119-t1x9gknd 11103 33 route route NN cord-010119-t1x9gknd 11103 34 for for IN cord-010119-t1x9gknd 11103 35 delivery delivery NN cord-010119-t1x9gknd 11103 36 of of IN cord-010119-t1x9gknd 11103 37 blood blood NN cord-010119-t1x9gknd 11103 38 . . . cord-010119-t1x9gknd 11104 1 Department department NN cord-010119-t1x9gknd 11104 2 educators educator NNS cord-010119-t1x9gknd 11104 3 requested request VBD cord-010119-t1x9gknd 11104 4 support support NN cord-010119-t1x9gknd 11104 5 to to TO cord-010119-t1x9gknd 11104 6 create create VB cord-010119-t1x9gknd 11104 7 job job NN cord-010119-t1x9gknd 11104 8 aids aid NNS cord-010119-t1x9gknd 11104 9 specific specific JJ cord-010119-t1x9gknd 11104 10 to to TO cord-010119-t1x9gknd 11104 11 workflow workflow VB cord-010119-t1x9gknd 11104 12 changes change NNS cord-010119-t1x9gknd 11104 13 impacting impact VBG cord-010119-t1x9gknd 11104 14 their -PRON- PRP$ cord-010119-t1x9gknd 11104 15 departments department NNS cord-010119-t1x9gknd 11104 16 , , , cord-010119-t1x9gknd 11104 17 such such JJ cord-010119-t1x9gknd 11104 18 as as IN cord-010119-t1x9gknd 11104 19 how how WRB cord-010119-t1x9gknd 11104 20 to to TO cord-010119-t1x9gknd 11104 21 order order VB cord-010119-t1x9gknd 11104 22 Rh Rh NNP cord-010119-t1x9gknd 11104 23 immune immune JJ cord-010119-t1x9gknd 11104 24 globulin globulin NN cord-010119-t1x9gknd 11104 25 , , , cord-010119-t1x9gknd 11104 26 a a DT cord-010119-t1x9gknd 11104 27 cord cord NN cord-010119-t1x9gknd 11104 28 blood blood NN cord-010119-t1x9gknd 11104 29 workup workup NN cord-010119-t1x9gknd 11104 30 , , , cord-010119-t1x9gknd 11104 31 etc etc FW cord-010119-t1x9gknd 11104 32 . . . cord-010119-t1x9gknd 11105 1 Conclusion conclusion NN cord-010119-t1x9gknd 11105 2 : : : cord-010119-t1x9gknd 11106 1 Leadership leadership NN cord-010119-t1x9gknd 11106 2 was be VBD cord-010119-t1x9gknd 11106 3 challenged challenge VBN cord-010119-t1x9gknd 11106 4 to to TO cord-010119-t1x9gknd 11106 5 provide provide VB cord-010119-t1x9gknd 11106 6 a a DT cord-010119-t1x9gknd 11106 7 stable stable JJ cord-010119-t1x9gknd 11106 8 and and CC cord-010119-t1x9gknd 11106 9 positive positive JJ cord-010119-t1x9gknd 11106 10 environment environment NN cord-010119-t1x9gknd 11106 11 during during IN cord-010119-t1x9gknd 11106 12 a a DT cord-010119-t1x9gknd 11106 13 complex complex JJ cord-010119-t1x9gknd 11106 14 set set NN cord-010119-t1x9gknd 11106 15 of of IN cord-010119-t1x9gknd 11106 16 changes change NNS cord-010119-t1x9gknd 11106 17 . . . cord-010119-t1x9gknd 11107 1 The the DT cord-010119-t1x9gknd 11107 2 simultaneous simultaneous JJ cord-010119-t1x9gknd 11107 3 hospital hospital NN cord-010119-t1x9gknd 11107 4 move move NN cord-010119-t1x9gknd 11107 5 / / SYM cord-010119-t1x9gknd 11107 6 merger merger NN cord-010119-t1x9gknd 11107 7 and and CC cord-010119-t1x9gknd 11107 8 implementation implementation NN cord-010119-t1x9gknd 11107 9 of of IN cord-010119-t1x9gknd 11107 10 a a DT cord-010119-t1x9gknd 11107 11 new new JJ cord-010119-t1x9gknd 11107 12 eHR eHR NFP cord-010119-t1x9gknd 11107 13 constituted constitute VBD cord-010119-t1x9gknd 11107 14 an an DT cord-010119-t1x9gknd 11107 15 arduous arduous JJ cord-010119-t1x9gknd 11107 16 task task NN cord-010119-t1x9gknd 11107 17 that that WDT cord-010119-t1x9gknd 11107 18 would would MD cord-010119-t1x9gknd 11107 19 not not RB cord-010119-t1x9gknd 11107 20 have have VB cord-010119-t1x9gknd 11107 21 been be VBN cord-010119-t1x9gknd 11107 22 possible possible JJ cord-010119-t1x9gknd 11107 23 had have VBD cord-010119-t1x9gknd 11107 24 substantial substantial JJ cord-010119-t1x9gknd 11107 25 preparations preparation NNS cord-010119-t1x9gknd 11107 26 not not RB cord-010119-t1x9gknd 11107 27 been be VBN cord-010119-t1x9gknd 11107 28 initiated initiate VBN cord-010119-t1x9gknd 11107 29 a a DT cord-010119-t1x9gknd 11107 30 year year NN cord-010119-t1x9gknd 11107 31 in in IN cord-010119-t1x9gknd 11107 32 advance advance NN cord-010119-t1x9gknd 11107 33 . . . cord-010119-t1x9gknd 11108 1 Training training NN cord-010119-t1x9gknd 11108 2 is be VBZ cord-010119-t1x9gknd 11108 3 essential essential JJ cord-010119-t1x9gknd 11108 4 to to IN cord-010119-t1x9gknd 11108 5 the the DT cord-010119-t1x9gknd 11108 6 success success NN cord-010119-t1x9gknd 11108 7 for for IN cord-010119-t1x9gknd 11108 8 a a DT cord-010119-t1x9gknd 11108 9 scope scope NN cord-010119-t1x9gknd 11108 10 of of IN cord-010119-t1x9gknd 11108 11 change change NN cord-010119-t1x9gknd 11108 12 this this DT cord-010119-t1x9gknd 11108 13 big big JJ cord-010119-t1x9gknd 11108 14 and and CC cord-010119-t1x9gknd 11108 15 should should MD cord-010119-t1x9gknd 11108 16 not not RB cord-010119-t1x9gknd 11108 17 be be VB cord-010119-t1x9gknd 11108 18 minimized minimize VBN cord-010119-t1x9gknd 11108 19 . . . cord-010119-t1x9gknd 11109 1 While while IN cord-010119-t1x9gknd 11109 2 training training NN cord-010119-t1x9gknd 11109 3 was be VBD cord-010119-t1x9gknd 11109 4 thorough thorough JJ cord-010119-t1x9gknd 11109 5 prior prior RB cord-010119-t1x9gknd 11109 6 to to IN cord-010119-t1x9gknd 11109 7 the the DT cord-010119-t1x9gknd 11109 8 move move NN cord-010119-t1x9gknd 11109 9 , , , cord-010119-t1x9gknd 11109 10 gaps gap NNS cord-010119-t1x9gknd 11109 11 were be VBD cord-010119-t1x9gknd 11109 12 nonetheless nonetheless RB cord-010119-t1x9gknd 11109 13 discovered discover VBN cord-010119-t1x9gknd 11109 14 following follow VBG cord-010119-t1x9gknd 11109 15 the the DT cord-010119-t1x9gknd 11109 16 move move NN cord-010119-t1x9gknd 11109 17 . . . cord-010119-t1x9gknd 11110 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 11110 2 Conclusion Conclusion NNP cord-010119-t1x9gknd 11110 3 : : : cord-010119-t1x9gknd 11110 4 strategic strategic JJ cord-010119-t1x9gknd 11110 5 development development NN cord-010119-t1x9gknd 11110 6 partners partner NNS cord-010119-t1x9gknd 11110 7 funding funding NN cord-010119-t1x9gknd 11110 8 and and CC cord-010119-t1x9gknd 11110 9 support support NN cord-010119-t1x9gknd 11110 10 based base VBN cord-010119-t1x9gknd 11110 11 on on IN cord-010119-t1x9gknd 11110 12 newly newly RB cord-010119-t1x9gknd 11110 13 developed develop VBN cord-010119-t1x9gknd 11110 14 government government NN cord-010119-t1x9gknd 11110 15 strategy strategy NN cord-010119-t1x9gknd 11110 16 on on IN cord-010119-t1x9gknd 11110 17 Blood blood NN cord-010119-t1x9gknd 11110 18 service service NN cord-010119-t1x9gknd 11110 19 with with IN cord-010119-t1x9gknd 11110 20 commitment commitment NN cord-010119-t1x9gknd 11110 21 of of IN cord-010119-t1x9gknd 11110 22 the the DT cord-010119-t1x9gknd 11110 23 government government NN cord-010119-t1x9gknd 11110 24 has have VBZ cord-010119-t1x9gknd 11110 25 brought bring VBN cord-010119-t1x9gknd 11110 26 a a DT cord-010119-t1x9gknd 11110 27 positive positive JJ cord-010119-t1x9gknd 11110 28 impact impact NN cord-010119-t1x9gknd 11110 29 in in IN cord-010119-t1x9gknd 11110 30 establishing establish VBG cord-010119-t1x9gknd 11110 31 sustainable sustainable JJ cord-010119-t1x9gknd 11110 32 and and CC cord-010119-t1x9gknd 11110 33 safe safe JJ cord-010119-t1x9gknd 11110 34 national national JJ cord-010119-t1x9gknd 11110 35 blood blood NN cord-010119-t1x9gknd 11110 36 service service NN cord-010119-t1x9gknd 11110 37 program program NN cord-010119-t1x9gknd 11110 38 in in IN cord-010119-t1x9gknd 11110 39 Ethiopia Ethiopia NNP cord-010119-t1x9gknd 11110 40 . . . cord-010119-t1x9gknd 11111 1 Even even RB cord-010119-t1x9gknd 11111 2 though though IN cord-010119-t1x9gknd 11111 3 the the DT cord-010119-t1x9gknd 11111 4 identified identify VBN cord-010119-t1x9gknd 11111 5 positive positive JJ cord-010119-t1x9gknd 11111 6 impacts impact NNS cord-010119-t1x9gknd 11111 7 mentioned mention VBN cord-010119-t1x9gknd 11111 8 are be VBP cord-010119-t1x9gknd 11111 9 achieved achieve VBN cord-010119-t1x9gknd 11111 10 , , , cord-010119-t1x9gknd 11111 11 the the DT cord-010119-t1x9gknd 11111 12 BTS BTS NNP cord-010119-t1x9gknd 11111 13 remains remain VBZ cord-010119-t1x9gknd 11111 14 with with IN cord-010119-t1x9gknd 11111 15 multiple multiple JJ cord-010119-t1x9gknd 11111 16 challenges challenge NNS cord-010119-t1x9gknd 11111 17 and and CC cord-010119-t1x9gknd 11111 18 needs need VBZ cord-010119-t1x9gknd 11111 19 continuity continuity NN cord-010119-t1x9gknd 11111 20 of of IN cord-010119-t1x9gknd 11111 21 funding funding NN cord-010119-t1x9gknd 11111 22 and and CC cord-010119-t1x9gknd 11111 23 more more JJR cord-010119-t1x9gknd 11111 24 partner partner NN cord-010119-t1x9gknd 11111 25 support support NN cord-010119-t1x9gknd 11111 26 and and CC cord-010119-t1x9gknd 11111 27 government government NN cord-010119-t1x9gknd 11111 28 commitment commitment NN cord-010119-t1x9gknd 11111 29 . . . cord-010119-t1x9gknd 11112 1 Pilot pilot NN cord-010119-t1x9gknd 11112 2 Implementation implementation NN cord-010119-t1x9gknd 11112 3 of of IN cord-010119-t1x9gknd 11112 4 a a DT cord-010119-t1x9gknd 11112 5 Comprehensive Comprehensive NNP cord-010119-t1x9gknd 11112 6 Hybrid Hybrid NNP cord-010119-t1x9gknd 11112 7 Performance Performance NNP cord-010119-t1x9gknd 11112 8 Management Management NNP cord-010119-t1x9gknd 11112 9 System System NNP cord-010119-t1x9gknd 11112 10 at at IN cord-010119-t1x9gknd 11112 11 National National NNP cord-010119-t1x9gknd 11112 12 Blood Blood NNP cord-010119-t1x9gknd 11112 13 Service Service NNP cord-010119-t1x9gknd 11112 14 Zimbabwe Zimbabwe NNP cord-010119-t1x9gknd 11112 15 Blessing Blessing NNP cord-010119-t1x9gknd 11112 16 Mukwada Mukwada NNP cord-010119-t1x9gknd 11113 1 * * NFP cord-010119-t1x9gknd 11113 2 , , , cord-010119-t1x9gknd 11113 3 Judith Judith NNP cord-010119-t1x9gknd 11113 4 J J NNP cord-010119-t1x9gknd 11113 5 Parirewa Parirewa NNP cord-010119-t1x9gknd 11113 6 and and CC cord-010119-t1x9gknd 11113 7 Tonderai Tonderai NNP cord-010119-t1x9gknd 11113 8 Mapako Mapako NNP cord-010119-t1x9gknd 11113 9 . . . cord-010119-t1x9gknd 11114 1 National National NNP cord-010119-t1x9gknd 11114 2 Blood Blood NNP cord-010119-t1x9gknd 11114 3 Service Service NNP cord-010119-t1x9gknd 11114 4 Zimbabwe Zimbabwe NNP cord-010119-t1x9gknd 11114 5 Background Background NNP cord-010119-t1x9gknd 11114 6 / / SYM cord-010119-t1x9gknd 11114 7 Case Case NNP cord-010119-t1x9gknd 11114 8 Studies Studies NNPS cord-010119-t1x9gknd 11114 9 : : : cord-010119-t1x9gknd 11115 1 The the DT cord-010119-t1x9gknd 11115 2 National National NNP cord-010119-t1x9gknd 11115 3 Blood Blood NNP cord-010119-t1x9gknd 11115 4 Service Service NNP cord-010119-t1x9gknd 11115 5 Zimbabwe Zimbabwe NNP cord-010119-t1x9gknd 11115 6 ( ( -LRB- cord-010119-t1x9gknd 11115 7 NBSZ NBSZ NNP cord-010119-t1x9gknd 11115 8 ) ) -RRB- cord-010119-t1x9gknd 11115 9 introduced introduce VBD cord-010119-t1x9gknd 11115 10 its -PRON- PRP$ cord-010119-t1x9gknd 11115 11 first first JJ cord-010119-t1x9gknd 11115 12 Performance Performance NNP cord-010119-t1x9gknd 11115 13 Management Management NNP cord-010119-t1x9gknd 11115 14 System System NNP cord-010119-t1x9gknd 11115 15 ( ( -LRB- cord-010119-t1x9gknd 11115 16 PMS PMS NNP cord-010119-t1x9gknd 11115 17 ) ) -RRB- cord-010119-t1x9gknd 11115 18 in in IN cord-010119-t1x9gknd 11115 19 2006 2006 CD cord-010119-t1x9gknd 11115 20 . . . cord-010119-t1x9gknd 11116 1 In in IN cord-010119-t1x9gknd 11116 2 the the DT cord-010119-t1x9gknd 11116 3 2015 2015 CD cord-010119-t1x9gknd 11116 4 - - SYM cord-010119-t1x9gknd 11116 5 2018 2018 CD cord-010119-t1x9gknd 11116 6 NBSZ NBSZ NNP cord-010119-t1x9gknd 11116 7 strategic strategic JJ cord-010119-t1x9gknd 11116 8 plan plan NN cord-010119-t1x9gknd 11116 9 it -PRON- PRP cord-010119-t1x9gknd 11116 10 was be VBD cord-010119-t1x9gknd 11116 11 noted note VBN cord-010119-t1x9gknd 11116 12 that that IN cord-010119-t1x9gknd 11116 13 the the DT cord-010119-t1x9gknd 11116 14 current current JJ cord-010119-t1x9gknd 11116 15 PMS PMS NNP cord-010119-t1x9gknd 11116 16 lacked lack VBD cord-010119-t1x9gknd 11116 17 objectivitety objectivitety NN cord-010119-t1x9gknd 11116 18 and and CC cord-010119-t1x9gknd 11116 19 there there EX cord-010119-t1x9gknd 11116 20 was be VBD cord-010119-t1x9gknd 11116 21 no no DT cord-010119-t1x9gknd 11116 22 relationship relationship NN cord-010119-t1x9gknd 11116 23 between between IN cord-010119-t1x9gknd 11116 24 perfomance perfomance NN cord-010119-t1x9gknd 11116 25 and and CC cord-010119-t1x9gknd 11116 26 remuneration remuneration NN cord-010119-t1x9gknd 11116 27 . . . cord-010119-t1x9gknd 11117 1 In in IN cord-010119-t1x9gknd 11117 2 order order NN cord-010119-t1x9gknd 11117 3 to to TO cord-010119-t1x9gknd 11117 4 revise revise VB cord-010119-t1x9gknd 11117 5 the the DT cord-010119-t1x9gknd 11117 6 PMS PMS NNP cord-010119-t1x9gknd 11117 7 , , , cord-010119-t1x9gknd 11117 8 the the DT cord-010119-t1x9gknd 11117 9 NBSZ NBSZ NNP cord-010119-t1x9gknd 11117 10 set set VBD cord-010119-t1x9gknd 11117 11 up up RP cord-010119-t1x9gknd 11117 12 a a DT cord-010119-t1x9gknd 11117 13 three three CD cord-010119-t1x9gknd 11117 14 membered membered NNP cord-010119-t1x9gknd 11117 15 committee committee NN cord-010119-t1x9gknd 11117 16 at at IN cord-010119-t1x9gknd 11117 17 the the DT cord-010119-t1x9gknd 11117 18 Executive Executive NNP cord-010119-t1x9gknd 11117 19 Management Management NNP cord-010119-t1x9gknd 11117 20 level level NN cord-010119-t1x9gknd 11117 21 to to TO cord-010119-t1x9gknd 11117 22 spearhead spearhead VB cord-010119-t1x9gknd 11117 23 the the DT cord-010119-t1x9gknd 11117 24 revamp revamp NN cord-010119-t1x9gknd 11117 25 of of IN cord-010119-t1x9gknd 11117 26 the the DT cord-010119-t1x9gknd 11117 27 NBSZ NBSZ NNP cord-010119-t1x9gknd 11117 28 PMS PMS NNP cord-010119-t1x9gknd 11117 29 . . . cord-010119-t1x9gknd 11118 1 The the DT cord-010119-t1x9gknd 11118 2 aim aim NN cord-010119-t1x9gknd 11118 3 of of IN cord-010119-t1x9gknd 11118 4 the the DT cord-010119-t1x9gknd 11118 5 new new JJ cord-010119-t1x9gknd 11118 6 PMS PMS NNP cord-010119-t1x9gknd 11118 7 was be VBD cord-010119-t1x9gknd 11118 8 to to TO cord-010119-t1x9gknd 11118 9 achieve achieve VB cord-010119-t1x9gknd 11118 10 a a DT cord-010119-t1x9gknd 11118 11 shared share VBN cord-010119-t1x9gknd 11118 12 vision vision NN cord-010119-t1x9gknd 11118 13 of of IN cord-010119-t1x9gknd 11118 14 the the DT cord-010119-t1x9gknd 11118 15 purpose purpose NN cord-010119-t1x9gknd 11118 16 and and CC cord-010119-t1x9gknd 11118 17 objectives objective NNS cord-010119-t1x9gknd 11118 18 of of IN cord-010119-t1x9gknd 11118 19 the the DT cord-010119-t1x9gknd 11118 20 organization organization NN cord-010119-t1x9gknd 11118 21 , , , cord-010119-t1x9gknd 11118 22 helping help VBG cord-010119-t1x9gknd 11118 23 each each DT cord-010119-t1x9gknd 11118 24 staff staff NN cord-010119-t1x9gknd 11118 25 member member NN cord-010119-t1x9gknd 11118 26 to to TO cord-010119-t1x9gknd 11118 27 understand understand VB cord-010119-t1x9gknd 11118 28 and and CC cord-010119-t1x9gknd 11118 29 recognize recognize VB cord-010119-t1x9gknd 11118 30 the the DT cord-010119-t1x9gknd 11118 31 contribution contribution NN cord-010119-t1x9gknd 11118 32 to to IN cord-010119-t1x9gknd 11118 33 the the DT cord-010119-t1x9gknd 11118 34 strategic strategic JJ cord-010119-t1x9gknd 11118 35 plan plan NN cord-010119-t1x9gknd 11118 36 . . . cord-010119-t1x9gknd 11119 1 In in IN cord-010119-t1x9gknd 11119 2 this this DT cord-010119-t1x9gknd 11119 3 paper paper NN cord-010119-t1x9gknd 11119 4 , , , cord-010119-t1x9gknd 11119 5 we -PRON- PRP cord-010119-t1x9gknd 11119 6 share share VBP cord-010119-t1x9gknd 11119 7 how how WRB cord-010119-t1x9gknd 11119 8 NBSZ NBSZ NNP cord-010119-t1x9gknd 11119 9 revamped revamp VBD cord-010119-t1x9gknd 11119 10 and and CC cord-010119-t1x9gknd 11119 11 implemented implement VBD cord-010119-t1x9gknd 11119 12 its -PRON- PRP$ cord-010119-t1x9gknd 11119 13 new new JJ cord-010119-t1x9gknd 11119 14 hybrid hybrid JJ cord-010119-t1x9gknd 11119 15 PMS PMS NNP cord-010119-t1x9gknd 11119 16 that that WDT cord-010119-t1x9gknd 11119 17 derived derive VBD cord-010119-t1x9gknd 11119 18 its -PRON- PRP$ cord-010119-t1x9gknd 11119 19 inputs input NNS cord-010119-t1x9gknd 11119 20 from from IN cord-010119-t1x9gknd 11119 21 established established JJ cord-010119-t1x9gknd 11119 22 PMSs pms NNS cord-010119-t1x9gknd 11119 23 and and CC cord-010119-t1x9gknd 11119 24 NBSZ NBSZ NNP cord-010119-t1x9gknd 11119 25 monitoring monitoring NN cord-010119-t1x9gknd 11119 26 and and CC cord-010119-t1x9gknd 11119 27 evaluation evaluation NN cord-010119-t1x9gknd 11119 28 ( ( -LRB- cord-010119-t1x9gknd 11119 29 M&E m&e NN cord-010119-t1x9gknd 11119 30 ) ) -RRB- cord-010119-t1x9gknd 11119 31 process process NN cord-010119-t1x9gknd 11119 32 that that WDT cord-010119-t1x9gknd 11119 33 have have VBP cord-010119-t1x9gknd 11119 34 been be VBN cord-010119-t1x9gknd 11119 35 linked link VBN cord-010119-t1x9gknd 11119 36 together together RB cord-010119-t1x9gknd 11119 37 . . . cord-010119-t1x9gknd 11120 1 One one CD cord-010119-t1x9gknd 11120 2 - - HYPH cord-010119-t1x9gknd 11120 3 selected select VBN cord-010119-t1x9gknd 11120 4 departmental departmental JJ cord-010119-t1x9gknd 11120 5 results result NNS cord-010119-t1x9gknd 11120 6 for for IN cord-010119-t1x9gknd 11120 7 one one CD cord-010119-t1x9gknd 11120 8 quarter quarter NN cord-010119-t1x9gknd 11120 9 are be VBP cord-010119-t1x9gknd 11120 10 shared share VBN cord-010119-t1x9gknd 11120 11 to to TO cord-010119-t1x9gknd 11120 12 demonstrate demonstrate VB cord-010119-t1x9gknd 11120 13 how how WRB cord-010119-t1x9gknd 11120 14 the the DT cord-010119-t1x9gknd 11120 15 system system NN cord-010119-t1x9gknd 11120 16 works work VBZ cord-010119-t1x9gknd 11120 17 . . . cord-010119-t1x9gknd 11121 1 Study Study NNP cord-010119-t1x9gknd 11121 2 Design Design NNP cord-010119-t1x9gknd 11121 3 / / SYM cord-010119-t1x9gknd 11121 4 Method method NN cord-010119-t1x9gknd 11121 5 : : : cord-010119-t1x9gknd 11121 6 PMS PMS NNP cord-010119-t1x9gknd 11121 7 Committee Committee NNP cord-010119-t1x9gknd 11121 8 developed develop VBD cord-010119-t1x9gknd 11121 9 and and CC cord-010119-t1x9gknd 11121 10 shared share VBD cord-010119-t1x9gknd 11121 11 with with IN cord-010119-t1x9gknd 11121 12 Executive Executive NNP cord-010119-t1x9gknd 11121 13 Management Management NNP cord-010119-t1x9gknd 11121 14 a a DT cord-010119-t1x9gknd 11121 15 PMS PMS NNP cord-010119-t1x9gknd 11121 16 conceptual conceptual NN cord-010119-t1x9gknd 11121 17 and and CC cord-010119-t1x9gknd 11121 18 implementation implementation NN cord-010119-t1x9gknd 11121 19 framework framework NN cord-010119-t1x9gknd 11121 20 . . . cord-010119-t1x9gknd 11122 1 Consultations consultation NNS cord-010119-t1x9gknd 11122 2 including include VBG cord-010119-t1x9gknd 11122 3 field field NN cord-010119-t1x9gknd 11122 4 visits visit NNS cord-010119-t1x9gknd 11122 5 were be VBD cord-010119-t1x9gknd 11122 6 done do VBN cord-010119-t1x9gknd 11122 7 on on IN cord-010119-t1x9gknd 11122 8 three three CD cord-010119-t1x9gknd 11122 9 established establish VBN cord-010119-t1x9gknd 11122 10 PMS PMS NNP cord-010119-t1x9gknd 11122 11 to to TO cord-010119-t1x9gknd 11122 12 assess assess VB cord-010119-t1x9gknd 11122 13 suitability suitability NN cord-010119-t1x9gknd 11122 14 for for IN cord-010119-t1x9gknd 11122 15 NBSZ NBSZ NNP cord-010119-t1x9gknd 11122 16 adoption adoption NN cord-010119-t1x9gknd 11122 17 . . . cord-010119-t1x9gknd 11123 1 A a DT cord-010119-t1x9gknd 11123 2 hybrid hybrid JJ cord-010119-t1x9gknd 11123 3 PMS PMS NNP cord-010119-t1x9gknd 11123 4 was be VBD cord-010119-t1x9gknd 11123 5 adopted adopt VBN cord-010119-t1x9gknd 11123 6 for for IN cord-010119-t1x9gknd 11123 7 NBSZ NBSZ NNP cord-010119-t1x9gknd 11123 8 and and CC cord-010119-t1x9gknd 11123 9 a a DT cord-010119-t1x9gknd 11123 10 pilot pilot NN cord-010119-t1x9gknd 11123 11 application application NN cord-010119-t1x9gknd 11123 12 for for IN cord-010119-t1x9gknd 11123 13 one one CD cord-010119-t1x9gknd 11123 14 quarter quarter NN cord-010119-t1x9gknd 11123 15 on on IN cord-010119-t1x9gknd 11123 16 selected select VBN cord-010119-t1x9gknd 11123 17 department department NN cord-010119-t1x9gknd 11123 18 was be VBD cord-010119-t1x9gknd 11123 19 done do VBN cord-010119-t1x9gknd 11123 20 . . . cord-010119-t1x9gknd 11124 1 Review review NN cord-010119-t1x9gknd 11124 2 of of IN cord-010119-t1x9gknd 11124 3 policy policy NN cord-010119-t1x9gknd 11124 4 , , , cord-010119-t1x9gknd 11124 5 procedures procedure NNS cord-010119-t1x9gknd 11124 6 to to IN cord-010119-t1x9gknd 11124 7 including include VBG cord-010119-t1x9gknd 11124 8 hybrid hybrid JJ cord-010119-t1x9gknd 11124 9 PMS PMS NNP cord-010119-t1x9gknd 11124 10 templates template NNS cord-010119-t1x9gknd 11124 11 and and CC cord-010119-t1x9gknd 11124 12 forms form NNS cord-010119-t1x9gknd 11124 13 were be VBD cord-010119-t1x9gknd 11124 14 done do VBN cord-010119-t1x9gknd 11124 15 . . . cord-010119-t1x9gknd 11125 1 PMS PMS NNP cord-010119-t1x9gknd 11125 2 Committee Committee NNP cord-010119-t1x9gknd 11125 3 trained train VBD cord-010119-t1x9gknd 11125 4 all all DT cord-010119-t1x9gknd 11125 5 staff staff NN cord-010119-t1x9gknd 11125 6 on on IN cord-010119-t1x9gknd 11125 7 how how WRB cord-010119-t1x9gknd 11125 8 to to TO cord-010119-t1x9gknd 11125 9 implement implement VB cord-010119-t1x9gknd 11125 10 an an DT cord-010119-t1x9gknd 11125 11 integrated integrate VBN cord-010119-t1x9gknd 11125 12 scorecard scorecard NN cord-010119-t1x9gknd 11125 13 , , , cord-010119-t1x9gknd 11125 14 how how WRB cord-010119-t1x9gknd 11125 15 to to TO cord-010119-t1x9gknd 11125 16 conduct conduct VB cord-010119-t1x9gknd 11125 17 appraisal appraisal NN cord-010119-t1x9gknd 11125 18 , , , cord-010119-t1x9gknd 11125 19 how how WRB cord-010119-t1x9gknd 11125 20 to to TO cord-010119-t1x9gknd 11125 21 develop develop VB cord-010119-t1x9gknd 11125 22 scorecards scorecard NNS cord-010119-t1x9gknd 11125 23 , , , cord-010119-t1x9gknd 11125 24 how how WRB cord-010119-t1x9gknd 11125 25 to to TO cord-010119-t1x9gknd 11125 26 measure measure VB cord-010119-t1x9gknd 11125 27 performance performance NN cord-010119-t1x9gknd 11125 28 using use VBG cord-010119-t1x9gknd 11125 29 the the DT cord-010119-t1x9gknd 11125 30 new new JJ cord-010119-t1x9gknd 11125 31 PMS PMS NNP cord-010119-t1x9gknd 11125 32 , , , cord-010119-t1x9gknd 11125 33 how how WRB cord-010119-t1x9gknd 11125 34 weighted weighted JJ cord-010119-t1x9gknd 11125 35 performance performance NN cord-010119-t1x9gknd 11125 36 reward reward NN cord-010119-t1x9gknd 11125 37 systems system NNS cord-010119-t1x9gknd 11125 38 based base VBN cord-010119-t1x9gknd 11125 39 on on IN cord-010119-t1x9gknd 11125 40 all all DT cord-010119-t1x9gknd 11125 41 layers layer NNS cord-010119-t1x9gknd 11125 42 of of IN cord-010119-t1x9gknd 11125 43 performance performance NN cord-010119-t1x9gknd 11125 44 for for IN cord-010119-t1x9gknd 11125 45 bonus bonus NN cord-010119-t1x9gknd 11125 46 payments payment NNS cord-010119-t1x9gknd 11125 47 works work NNS cord-010119-t1x9gknd 11125 48 using use VBG cord-010119-t1x9gknd 11125 49 standardised standardised JJ cord-010119-t1x9gknd 11125 50 tools tool NNS cord-010119-t1x9gknd 11125 51 . . . cord-010119-t1x9gknd 11126 1 Throughout throughout IN cord-010119-t1x9gknd 11126 2 the the DT cord-010119-t1x9gknd 11126 3 process process NN cord-010119-t1x9gknd 11126 4 risk risk NN cord-010119-t1x9gknd 11126 5 assessment assessment NN cord-010119-t1x9gknd 11126 6 were be VBD cord-010119-t1x9gknd 11126 7 done do VBN cord-010119-t1x9gknd 11126 8 . . . cord-010119-t1x9gknd 11127 1 Results/ Results/ . cord-010119-t1x9gknd 11128 1 Finding find VBG cord-010119-t1x9gknd 11128 2 : : : cord-010119-t1x9gknd 11128 3 The the DT cord-010119-t1x9gknd 11128 4 NBSZ NBSZ NNP cord-010119-t1x9gknd 11128 5 Hybrid Hybrid NNP cord-010119-t1x9gknd 11128 6 PMS PMS NNP cord-010119-t1x9gknd 11128 7 is be VBZ cord-010119-t1x9gknd 11128 8 based base VBN cord-010119-t1x9gknd 11128 9 on on IN cord-010119-t1x9gknd 11128 10 five five CD cord-010119-t1x9gknd 11128 11 levels level NNS cord-010119-t1x9gknd 11128 12 of of IN cord-010119-t1x9gknd 11128 13 planning plan VBG cord-010119-t1x9gknd 11128 14 namely namely RB cord-010119-t1x9gknd 11128 15 Strategic Strategic NNP cord-010119-t1x9gknd 11128 16 , , , cord-010119-t1x9gknd 11128 17 departmental departmental JJ cord-010119-t1x9gknd 11128 18 , , , cord-010119-t1x9gknd 11128 19 branch branch NN cord-010119-t1x9gknd 11128 20 , , , cord-010119-t1x9gknd 11128 21 sectional sectional JJ cord-010119-t1x9gknd 11128 22 and and CC cord-010119-t1x9gknd 11128 23 individual individual JJ cord-010119-t1x9gknd 11128 24 . . . cord-010119-t1x9gknd 11129 1 The the DT cord-010119-t1x9gknd 11129 2 fourcoloured fourcoloured JJ cord-010119-t1x9gknd 11129 3 traffic traffic NN cord-010119-t1x9gknd 11129 4 light light JJ cord-010119-t1x9gknd 11129 5 reporting report VBG cord-010119-t1x9gknd 11129 6 system system NN cord-010119-t1x9gknd 11129 7 is be VBZ cord-010119-t1x9gknd 11129 8 central central JJ cord-010119-t1x9gknd 11129 9 in in IN cord-010119-t1x9gknd 11129 10 uniformly uniformly RB cord-010119-t1x9gknd 11129 11 assessing assess VBG cord-010119-t1x9gknd 11129 12 performance performance NN cord-010119-t1x9gknd 11129 13 at at IN cord-010119-t1x9gknd 11129 14 all all DT cord-010119-t1x9gknd 11129 15 levels level NNS cord-010119-t1x9gknd 11129 16 . . . cord-010119-t1x9gknd 11130 1 The the DT cord-010119-t1x9gknd 11130 2 levels level NNS cord-010119-t1x9gknd 11130 3 of of IN cord-010119-t1x9gknd 11130 4 accountability accountability NN cord-010119-t1x9gknd 11130 5 were be VBD cord-010119-t1x9gknd 11130 6 properly properly RB cord-010119-t1x9gknd 11130 7 defined define VBN cord-010119-t1x9gknd 11130 8 for for IN cord-010119-t1x9gknd 11130 9 each each DT cord-010119-t1x9gknd 11130 10 level level NN cord-010119-t1x9gknd 11130 11 of of IN cord-010119-t1x9gknd 11130 12 planning planning NN cord-010119-t1x9gknd 11130 13 . . . cord-010119-t1x9gknd 11131 1 A a DT cord-010119-t1x9gknd 11131 2 weighted weighted JJ cord-010119-t1x9gknd 11131 3 overall overall JJ cord-010119-t1x9gknd 11131 4 integrated integrate VBN cord-010119-t1x9gknd 11131 5 individual individual JJ cord-010119-t1x9gknd 11131 6 scorecard scorecard NN cord-010119-t1x9gknd 11131 7 ( ( -LRB- cord-010119-t1x9gknd 11131 8 IIS IIS NNP cord-010119-t1x9gknd 11131 9 ) ) -RRB- cord-010119-t1x9gknd 11131 10 is be VBZ cord-010119-t1x9gknd 11131 11 determined determine VBN cord-010119-t1x9gknd 11131 12 based base VBN cord-010119-t1x9gknd 11131 13 on on IN cord-010119-t1x9gknd 11131 14 60 60 CD cord-010119-t1x9gknd 11131 15 % % NN cord-010119-t1x9gknd 11131 16 individual individual NN cord-010119-t1x9gknd 11131 17 and and CC cord-010119-t1x9gknd 11131 18 40 40 CD cord-010119-t1x9gknd 11131 19 % % NN cord-010119-t1x9gknd 11131 20 for for IN cord-010119-t1x9gknd 11131 21 the the DT cord-010119-t1x9gknd 11131 22 other other JJ cord-010119-t1x9gknd 11131 23 four four CD cord-010119-t1x9gknd 11131 24 levels level NNS cord-010119-t1x9gknd 11131 25 ( ( -LRB- cord-010119-t1x9gknd 11131 26 10 10 CD cord-010119-t1x9gknd 11131 27 % % NN cord-010119-t1x9gknd 11131 28 for for IN cord-010119-t1x9gknd 11131 29 each each DT cord-010119-t1x9gknd 11131 30 ) ) -RRB- cord-010119-t1x9gknd 11131 31 . . . cord-010119-t1x9gknd 11132 1 The the DT cord-010119-t1x9gknd 11132 2 bonus bonus NN cord-010119-t1x9gknd 11132 3 ( ( -LRB- cord-010119-t1x9gknd 11132 4 % % NN cord-010119-t1x9gknd 11132 5 ) ) -RRB- cord-010119-t1x9gknd 11132 6 is be VBZ cord-010119-t1x9gknd 11132 7 calculated calculate VBN cord-010119-t1x9gknd 11132 8 based base VBN cord-010119-t1x9gknd 11132 9 on on IN cord-010119-t1x9gknd 11132 10 the the DT cord-010119-t1x9gknd 11132 11 IIS IIS NNP cord-010119-t1x9gknd 11132 12 as as IN cord-010119-t1x9gknd 11132 13 follows follow VBZ cord-010119-t1x9gknd 11132 14 ; ; : cord-010119-t1x9gknd 11132 15 Category Category NNP cord-010119-t1x9gknd 11132 16 A a NN cord-010119-t1x9gknd 11132 17 : : : cord-010119-t1x9gknd 11132 18 100 100 CD cord-010119-t1x9gknd 11132 19 % % NN cord-010119-t1x9gknd 11132 20 ( ( -LRB- cord-010119-t1x9gknd 11132 21 IIS iis NN cord-010119-t1x9gknd 11132 22 > > XX cord-010119-t1x9gknd 11132 23 575 575 CD cord-010119-t1x9gknd 11132 24 % % NN cord-010119-t1x9gknd 11132 25 ) ) -RRB- cord-010119-t1x9gknd 11132 26 , , , cord-010119-t1x9gknd 11132 27 Category category NN cord-010119-t1x9gknd 11132 28 B B NNP cord-010119-t1x9gknd 11132 29 : : : cord-010119-t1x9gknd 11132 30 75 75 CD cord-010119-t1x9gknd 11132 31 % % NN cord-010119-t1x9gknd 11132 32 ( ( -LRB- cord-010119-t1x9gknd 11132 33 IIS iis NN cord-010119-t1x9gknd 11132 34 : : : cord-010119-t1x9gknd 11132 35 50 50 CD cord-010119-t1x9gknd 11132 36 -<75 -<75 NNS cord-010119-t1x9gknd 11132 37 % % NN cord-010119-t1x9gknd 11132 38 ) ) -RRB- cord-010119-t1x9gknd 11132 39 , , , cord-010119-t1x9gknd 11132 40 Category category NN cord-010119-t1x9gknd 11132 41 C c NN cord-010119-t1x9gknd 11132 42 : : : cord-010119-t1x9gknd 11132 43 50 50 CD cord-010119-t1x9gknd 11132 44 % % NN cord-010119-t1x9gknd 11132 45 ( ( -LRB- cord-010119-t1x9gknd 11132 46 IIS iis NN cord-010119-t1x9gknd 11132 47 : : : cord-010119-t1x9gknd 11132 48 25-<50 25-<50 CD cord-010119-t1x9gknd 11132 49 % % NN cord-010119-t1x9gknd 11132 50 ) ) -RRB- cord-010119-t1x9gknd 11132 51 and and CC cord-010119-t1x9gknd 11132 52 Category category NN cord-010119-t1x9gknd 11132 53 D d NN cord-010119-t1x9gknd 11132 54 : : : cord-010119-t1x9gknd 11132 55 0 0 CD cord-010119-t1x9gknd 11132 56 % % NN cord-010119-t1x9gknd 11132 57 ( ( -LRB- cord-010119-t1x9gknd 11132 58 IIS IIS NNP cord-010119-t1x9gknd 11132 59 < < XX cord-010119-t1x9gknd 11132 60 25 25 CD cord-010119-t1x9gknd 11132 61 % % NN cord-010119-t1x9gknd 11132 62 ) ) -RRB- cord-010119-t1x9gknd 11132 63 . . . cord-010119-t1x9gknd 11133 1 On on IN cord-010119-t1x9gknd 11133 2 the the DT cord-010119-t1x9gknd 11133 3 pilot pilot NN cord-010119-t1x9gknd 11133 4 implementation implementation NN cord-010119-t1x9gknd 11133 5 , , , cord-010119-t1x9gknd 11133 6 the the DT cord-010119-t1x9gknd 11133 7 individual individual JJ cord-010119-t1x9gknd 11133 8 scores score NNS cord-010119-t1x9gknd 11133 9 for for IN cord-010119-t1x9gknd 11133 10 12 12 CD cord-010119-t1x9gknd 11133 11 staff staff NN cord-010119-t1x9gknd 11133 12 ranged range VBD cord-010119-t1x9gknd 11133 13 from from IN cord-010119-t1x9gknd 11133 14 71 71 CD cord-010119-t1x9gknd 11133 15 % % NN cord-010119-t1x9gknd 11133 16 to to IN cord-010119-t1x9gknd 11133 17 100 100 CD cord-010119-t1x9gknd 11133 18 % % NN cord-010119-t1x9gknd 11133 19 . . . cord-010119-t1x9gknd 11134 1 The the DT cord-010119-t1x9gknd 11134 2 IIS IIS NNP cord-010119-t1x9gknd 11134 3 were be VBD cord-010119-t1x9gknd 11134 4 76 76 CD cord-010119-t1x9gknd 11134 5 % % NN cord-010119-t1x9gknd 11134 6 to to IN cord-010119-t1x9gknd 11134 7 81 81 CD cord-010119-t1x9gknd 11134 8 % % NN cord-010119-t1x9gknd 11134 9 . . . cord-010119-t1x9gknd 11135 1 The the DT cord-010119-t1x9gknd 11135 2 number number NN cord-010119-t1x9gknd 11135 3 of of IN cord-010119-t1x9gknd 11135 4 staff staff NN cord-010119-t1x9gknd 11135 5 in in IN cord-010119-t1x9gknd 11135 6 each each DT cord-010119-t1x9gknd 11135 7 bonus bonus NN cord-010119-t1x9gknd 11135 8 categories category NNS cord-010119-t1x9gknd 11135 9 were be VBD cord-010119-t1x9gknd 11135 10 11 11 CD cord-010119-t1x9gknd 11135 11 , , , cord-010119-t1x9gknd 11135 12 92 92 CD cord-010119-t1x9gknd 11135 13 % % NN cord-010119-t1x9gknd 11135 14 ( ( -LRB- cord-010119-t1x9gknd 11135 15 Category Category NNP cord-010119-t1x9gknd 11135 16 A A NNP cord-010119-t1x9gknd 11135 17 ) ) -RRB- cord-010119-t1x9gknd 11135 18 and and CC cord-010119-t1x9gknd 11135 19 1 1 CD cord-010119-t1x9gknd 11135 20 , , , cord-010119-t1x9gknd 11135 21 8 8 CD cord-010119-t1x9gknd 11135 22 % % NN cord-010119-t1x9gknd 11135 23 ( ( -LRB- cord-010119-t1x9gknd 11135 24 Category category NN cord-010119-t1x9gknd 11135 25 B B NNP cord-010119-t1x9gknd 11135 26 ) ) -RRB- cord-010119-t1x9gknd 11135 27 . . . cord-010119-t1x9gknd 11136 1 Conclusion conclusion NN cord-010119-t1x9gknd 11136 2 : : : cord-010119-t1x9gknd 11137 1 The the DT cord-010119-t1x9gknd 11137 2 new new JJ cord-010119-t1x9gknd 11137 3 hybrid hybrid JJ cord-010119-t1x9gknd 11137 4 PMS PMS NNP cord-010119-t1x9gknd 11137 5 was be VBD cord-010119-t1x9gknd 11137 6 generally generally RB cord-010119-t1x9gknd 11137 7 accepted accept VBN cord-010119-t1x9gknd 11137 8 by by IN cord-010119-t1x9gknd 11137 9 all all DT cord-010119-t1x9gknd 11137 10 staff staff NN cord-010119-t1x9gknd 11137 11 and and CC cord-010119-t1x9gknd 11137 12 it -PRON- PRP cord-010119-t1x9gknd 11137 13 was be VBD cord-010119-t1x9gknd 11137 14 easily easily RB cord-010119-t1x9gknd 11137 15 implemented implement VBN cord-010119-t1x9gknd 11137 16 at at IN cord-010119-t1x9gknd 11137 17 various various JJ cord-010119-t1x9gknd 11137 18 staff staff NN cord-010119-t1x9gknd 11137 19 levels level NNS cord-010119-t1x9gknd 11137 20 . . . cord-010119-t1x9gknd 11138 1 This this DT cord-010119-t1x9gknd 11138 2 provides provide VBZ cord-010119-t1x9gknd 11138 3 a a DT cord-010119-t1x9gknd 11138 4 basis basis NN cord-010119-t1x9gknd 11138 5 for for IN cord-010119-t1x9gknd 11138 6 the the DT cord-010119-t1x9gknd 11138 7 full full JJ cord-010119-t1x9gknd 11138 8 implementation implementation NN cord-010119-t1x9gknd 11138 9 of of IN cord-010119-t1x9gknd 11138 10 the the DT cord-010119-t1x9gknd 11138 11 new new JJ cord-010119-t1x9gknd 11138 12 PMS PMS NNP cord-010119-t1x9gknd 11138 13 and and CC cord-010119-t1x9gknd 11138 14 this this DT cord-010119-t1x9gknd 11138 15 simplified simplified JJ cord-010119-t1x9gknd 11138 16 PMS PMS NNP cord-010119-t1x9gknd 11138 17 can can MD cord-010119-t1x9gknd 11138 18 be be VB cord-010119-t1x9gknd 11138 19 easily easily RB cord-010119-t1x9gknd 11138 20 be be VB cord-010119-t1x9gknd 11138 21 adapted adapt VBN cord-010119-t1x9gknd 11138 22 in in IN cord-010119-t1x9gknd 11138 23 similar similar JJ cord-010119-t1x9gknd 11138 24 settings setting NNS cord-010119-t1x9gknd 11138 25 to to TO cord-010119-t1x9gknd 11138 26 ensure ensure VB cord-010119-t1x9gknd 11138 27 all all DT cord-010119-t1x9gknd 11138 28 staff staff NN cord-010119-t1x9gknd 11138 29 contribute contribute VBP cord-010119-t1x9gknd 11138 30 sufficiently sufficiently RB cord-010119-t1x9gknd 11138 31 and and CC cord-010119-t1x9gknd 11138 32 objectively objectively RB cord-010119-t1x9gknd 11138 33 to to IN cord-010119-t1x9gknd 11138 34 the the DT cord-010119-t1x9gknd 11138 35 realisation realisation NN cord-010119-t1x9gknd 11138 36 of of IN cord-010119-t1x9gknd 11138 37 the the DT cord-010119-t1x9gknd 11138 38 organisation organisation NN cord-010119-t1x9gknd 11138 39 strategic strategic JJ cord-010119-t1x9gknd 11138 40 vision vision NN cord-010119-t1x9gknd 11138 41 . . . cord-010119-t1x9gknd 11139 1 Rare Rare NNP cord-010119-t1x9gknd 11139 2 Donor Donor NNP cord-010119-t1x9gknd 11139 3 Engagement Engagement NNP cord-010119-t1x9gknd 11139 4 with with IN cord-010119-t1x9gknd 11139 5 American American NNP cord-010119-t1x9gknd 11139 6 Rare Rare NNP cord-010119-t1x9gknd 11139 7 Donor Donor NNP cord-010119-t1x9gknd 11139 8 Program Program NNP cord-010119-t1x9gknd 11139 9 ( ( -LRB- cord-010119-t1x9gknd 11139 10 ARDP ARDP NNP cord-010119-t1x9gknd 11139 11 ) ) -RRB- cord-010119-t1x9gknd 11140 1 Margaret Margaret NNP cord-010119-t1x9gknd 11140 2 C C NNP cord-010119-t1x9gknd 11140 3 Manigly Manigly NNP cord-010119-t1x9gknd 11141 1 * * NFP cord-010119-t1x9gknd 11141 2 1 1 CD cord-010119-t1x9gknd 11141 3 , , , cord-010119-t1x9gknd 11141 4 Deborah Deborah NNP cord-010119-t1x9gknd 11141 5 R R NNP cord-010119-t1x9gknd 11141 6 Fludd Fludd NNP cord-010119-t1x9gknd 11141 7 1 1 CD cord-010119-t1x9gknd 11141 8 and and CC cord-010119-t1x9gknd 11141 9 Sandra Sandra NNP cord-010119-t1x9gknd 11141 10 J J NNP cord-010119-t1x9gknd 11141 11 Nance Nance NNP cord-010119-t1x9gknd 11141 12 2 2 CD cord-010119-t1x9gknd 11141 13 . . . cord-010119-t1x9gknd 11142 1 Background Background NNP cord-010119-t1x9gknd 11142 2 / / SYM cord-010119-t1x9gknd 11142 3 Case Case NNP cord-010119-t1x9gknd 11142 4 Studies Studies NNPS cord-010119-t1x9gknd 11143 1 : : : cord-010119-t1x9gknd 11143 2 Rare rare JJ cord-010119-t1x9gknd 11143 3 donors donor NNS cord-010119-t1x9gknd 11143 4 are be VBP cord-010119-t1x9gknd 11143 5 defined define VBN cord-010119-t1x9gknd 11143 6 as as IN cord-010119-t1x9gknd 11143 7 a a DT cord-010119-t1x9gknd 11143 8 blood blood NN cord-010119-t1x9gknd 11143 9 type type NN cord-010119-t1x9gknd 11143 10 occurring occur VBG cord-010119-t1x9gknd 11143 11 in in IN cord-010119-t1x9gknd 11143 12 less less JJR cord-010119-t1x9gknd 11143 13 than than IN cord-010119-t1x9gknd 11143 14 1 1 CD cord-010119-t1x9gknd 11143 15 in in IN cord-010119-t1x9gknd 11143 16 1000 1000 CD cord-010119-t1x9gknd 11143 17 people people NNS cord-010119-t1x9gknd 11143 18 in in IN cord-010119-t1x9gknd 11143 19 a a DT cord-010119-t1x9gknd 11143 20 given give VBN cord-010119-t1x9gknd 11143 21 population population NN cord-010119-t1x9gknd 11143 22 . . . cord-010119-t1x9gknd 11144 1 These these DT cord-010119-t1x9gknd 11144 2 donors donor NNS cord-010119-t1x9gknd 11144 3 are be VBP cord-010119-t1x9gknd 11144 4 discovered discover VBN cord-010119-t1x9gknd 11144 5 by by IN cord-010119-t1x9gknd 11144 6 testing test VBG cord-010119-t1x9gknd 11144 7 new new JJ cord-010119-t1x9gknd 11144 8 donors donor NNS cord-010119-t1x9gknd 11144 9 in in IN cord-010119-t1x9gknd 11144 10 a a DT cord-010119-t1x9gknd 11144 11 random random JJ cord-010119-t1x9gknd 11144 12 or or CC cord-010119-t1x9gknd 11144 13 targeted target VBN cord-010119-t1x9gknd 11144 14 way way NN cord-010119-t1x9gknd 11144 15 and and CC cord-010119-t1x9gknd 11144 16 require require VB cord-010119-t1x9gknd 11144 17 testing test VBG cord-010119-t1x9gknd 11144 18 many many JJ cord-010119-t1x9gknd 11144 19 donors donor NNS cord-010119-t1x9gknd 11144 20 to to TO cord-010119-t1x9gknd 11144 21 find find VB cord-010119-t1x9gknd 11144 22 one one CD cord-010119-t1x9gknd 11144 23 rare rare JJ cord-010119-t1x9gknd 11144 24 donor donor NN cord-010119-t1x9gknd 11144 25 . . . cord-010119-t1x9gknd 11145 1 Once once RB cord-010119-t1x9gknd 11145 2 found find VBN cord-010119-t1x9gknd 11145 3 , , , cord-010119-t1x9gknd 11145 4 if if IN cord-010119-t1x9gknd 11145 5 the the DT cord-010119-t1x9gknd 11145 6 facility facility NN cord-010119-t1x9gknd 11145 7 is be VBZ cord-010119-t1x9gknd 11145 8 a a DT cord-010119-t1x9gknd 11145 9 member member NN cord-010119-t1x9gknd 11145 10 of of IN cord-010119-t1x9gknd 11145 11 the the DT cord-010119-t1x9gknd 11145 12 American American NNP cord-010119-t1x9gknd 11145 13 Rare Rare NNP cord-010119-t1x9gknd 11145 14 Donor Donor NNP cord-010119-t1x9gknd 11145 15 Program Program NNP cord-010119-t1x9gknd 11145 16 ( ( -LRB- cord-010119-t1x9gknd 11145 17 by by IN cord-010119-t1x9gknd 11145 18 being be VBG cord-010119-t1x9gknd 11145 19 an an DT cord-010119-t1x9gknd 11145 20 AABB AABB NNP cord-010119-t1x9gknd 11145 21 Accredited Accredited NNP cord-010119-t1x9gknd 11145 22 or or CC cord-010119-t1x9gknd 11145 23 American American NNP cord-010119-t1x9gknd 11145 24 Red Red NNP cord-010119-t1x9gknd 11145 25 Cross Cross NNP cord-010119-t1x9gknd 11145 26 accredited accredit VBD cord-010119-t1x9gknd 11145 27 IRL IRL NNP cord-010119-t1x9gknd 11145 28 ) ) -RRB- cord-010119-t1x9gknd 11145 29 , , , cord-010119-t1x9gknd 11145 30 the the DT cord-010119-t1x9gknd 11145 31 donor donor NN cord-010119-t1x9gknd 11145 32 is be VBZ cord-010119-t1x9gknd 11145 33 registered register VBN cord-010119-t1x9gknd 11145 34 in in IN cord-010119-t1x9gknd 11145 35 the the DT cord-010119-t1x9gknd 11145 36 ARDP ARDP NNP cord-010119-t1x9gknd 11145 37 database database NN cord-010119-t1x9gknd 11145 38 as as IN cord-010119-t1x9gknd 11145 39 a a DT cord-010119-t1x9gknd 11145 40 rare rare JJ cord-010119-t1x9gknd 11145 41 donor donor NN cord-010119-t1x9gknd 11145 42 . . . cord-010119-t1x9gknd 11146 1 In in IN cord-010119-t1x9gknd 11146 2 2016 2016 CD cord-010119-t1x9gknd 11146 3 , , , cord-010119-t1x9gknd 11146 4 there there EX cord-010119-t1x9gknd 11146 5 were be VBD cord-010119-t1x9gknd 11146 6 65,801 65,801 CD cord-010119-t1x9gknd 11146 7 active active JJ cord-010119-t1x9gknd 11146 8 rare rare JJ cord-010119-t1x9gknd 11146 9 donors donor NNS cord-010119-t1x9gknd 11146 10 in in IN cord-010119-t1x9gknd 11146 11 the the DT cord-010119-t1x9gknd 11146 12 ARDP ARDP NNP cord-010119-t1x9gknd 11146 13 . . . cord-010119-t1x9gknd 11147 1 With with IN cord-010119-t1x9gknd 11147 2 the the DT cord-010119-t1x9gknd 11147 3 mobility mobility NN cord-010119-t1x9gknd 11147 4 of of IN cord-010119-t1x9gknd 11147 5 the the DT cord-010119-t1x9gknd 11147 6 population population NN cord-010119-t1x9gknd 11147 7 in in IN cord-010119-t1x9gknd 11147 8 the the DT cord-010119-t1x9gknd 11147 9 USA USA NNP cord-010119-t1x9gknd 11147 10 , , , cord-010119-t1x9gknd 11147 11 it -PRON- PRP cord-010119-t1x9gknd 11147 12 is be VBZ cord-010119-t1x9gknd 11147 13 important important JJ cord-010119-t1x9gknd 11147 14 that that IN cord-010119-t1x9gknd 11147 15 as as IN cord-010119-t1x9gknd 11147 16 donors donor NNS cord-010119-t1x9gknd 11147 17 relocate relocate VBP cord-010119-t1x9gknd 11147 18 , , , cord-010119-t1x9gknd 11147 19 that that IN cord-010119-t1x9gknd 11147 20 they -PRON- PRP cord-010119-t1x9gknd 11147 21 are be VBP cord-010119-t1x9gknd 11147 22 recognized recognize VBN cord-010119-t1x9gknd 11147 23 as as IN cord-010119-t1x9gknd 11147 24 a a DT cord-010119-t1x9gknd 11147 25 rare rare JJ cord-010119-t1x9gknd 11147 26 donor donor NN cord-010119-t1x9gknd 11147 27 when when WRB cord-010119-t1x9gknd 11147 28 they -PRON- PRP cord-010119-t1x9gknd 11147 29 donate donate VBP cord-010119-t1x9gknd 11147 30 and and CC cord-010119-t1x9gknd 11147 31 their -PRON- PRP$ cord-010119-t1x9gknd 11147 32 unit unit NN cord-010119-t1x9gknd 11147 33 can can MD cord-010119-t1x9gknd 11147 34 be be VB cord-010119-t1x9gknd 11147 35 identified identify VBN cord-010119-t1x9gknd 11147 36 and and CC cord-010119-t1x9gknd 11147 37 used use VBN cord-010119-t1x9gknd 11147 38 for for IN cord-010119-t1x9gknd 11147 39 a a DT cord-010119-t1x9gknd 11147 40 patient patient NN cord-010119-t1x9gknd 11147 41 with with IN cord-010119-t1x9gknd 11147 42 a a DT cord-010119-t1x9gknd 11147 43 rare rare JJ cord-010119-t1x9gknd 11147 44 blood blood NN cord-010119-t1x9gknd 11147 45 need need NN cord-010119-t1x9gknd 11147 46 . . . cord-010119-t1x9gknd 11148 1 In in IN cord-010119-t1x9gknd 11148 2 addition addition NN cord-010119-t1x9gknd 11148 3 , , , cord-010119-t1x9gknd 11148 4 when when WRB cord-010119-t1x9gknd 11148 5 recruitment recruitment NN cord-010119-t1x9gknd 11148 6 is be VBZ cord-010119-t1x9gknd 11148 7 needed need VBN cord-010119-t1x9gknd 11148 8 for for IN cord-010119-t1x9gknd 11148 9 a a DT cord-010119-t1x9gknd 11148 10 patient patient JJ cord-010119-t1x9gknd 11148 11 need need NN cord-010119-t1x9gknd 11148 12 , , , cord-010119-t1x9gknd 11148 13 correct correct VB cord-010119-t1x9gknd 11148 14 contact contact NN cord-010119-t1x9gknd 11148 15 information information NN cord-010119-t1x9gknd 11148 16 on on IN cord-010119-t1x9gknd 11148 17 the the DT cord-010119-t1x9gknd 11148 18 donor donor NN cord-010119-t1x9gknd 11148 19 is be VBZ cord-010119-t1x9gknd 11148 20 required require VBN cord-010119-t1x9gknd 11148 21 . . . cord-010119-t1x9gknd 11149 1 Study Study NNP cord-010119-t1x9gknd 11149 2 Design Design NNP cord-010119-t1x9gknd 11149 3 / / SYM cord-010119-t1x9gknd 11149 4 Method method NN cord-010119-t1x9gknd 11149 5 : : : cord-010119-t1x9gknd 11150 1 The the DT cord-010119-t1x9gknd 11150 2 ARDP ARDP NNP cord-010119-t1x9gknd 11150 3 procedure procedure NN cord-010119-t1x9gknd 11150 4 for for IN cord-010119-t1x9gknd 11150 5 ARDP ARDP NNP cord-010119-t1x9gknd 11150 6 members member NNS cord-010119-t1x9gknd 11150 7 requires require VBZ cord-010119-t1x9gknd 11150 8 that that IN cord-010119-t1x9gknd 11150 9 donors donor NNS cord-010119-t1x9gknd 11150 10 be be VB cord-010119-t1x9gknd 11150 11 contacted contact VBN cord-010119-t1x9gknd 11150 12 every every DT cord-010119-t1x9gknd 11150 13 six six CD cord-010119-t1x9gknd 11150 14 months month NNS cord-010119-t1x9gknd 11150 15 to to TO cord-010119-t1x9gknd 11150 16 ensure ensure VB cord-010119-t1x9gknd 11150 17 that that IN cord-010119-t1x9gknd 11150 18 ARDP ARDP NNP cord-010119-t1x9gknd 11150 19 ( ( -LRB- cord-010119-t1x9gknd 11150 20 or or CC cord-010119-t1x9gknd 11150 21 the the DT cord-010119-t1x9gknd 11150 22 facility facility NN cord-010119-t1x9gknd 11150 23 ) ) -RRB- cord-010119-t1x9gknd 11150 24 has have VBZ cord-010119-t1x9gknd 11150 25 their -PRON- PRP$ cord-010119-t1x9gknd 11150 26 latest late JJS cord-010119-t1x9gknd 11150 27 contact contact NN cord-010119-t1x9gknd 11150 28 information information NN cord-010119-t1x9gknd 11150 29 . . . cord-010119-t1x9gknd 11151 1 The the DT cord-010119-t1x9gknd 11151 2 timing timing NN cord-010119-t1x9gknd 11151 3 is be VBZ cord-010119-t1x9gknd 11151 4 determined determine VBN cord-010119-t1x9gknd 11151 5 by by IN cord-010119-t1x9gknd 11151 6 the the DT cord-010119-t1x9gknd 11151 7 postal postal JJ cord-010119-t1x9gknd 11151 8 service service NN cord-010119-t1x9gknd 11151 9 time time NN cord-010119-t1x9gknd 11151 10 limit limit NN cord-010119-t1x9gknd 11151 11 of of IN cord-010119-t1x9gknd 11151 12 six six CD cord-010119-t1x9gknd 11151 13 months month NNS cord-010119-t1x9gknd 11151 14 to to TO cord-010119-t1x9gknd 11151 15 forward forward VB cord-010119-t1x9gknd 11151 16 mail mail NN cord-010119-t1x9gknd 11151 17 to to IN cord-010119-t1x9gknd 11151 18 a a DT cord-010119-t1x9gknd 11151 19 new new JJ cord-010119-t1x9gknd 11151 20 address address NN cord-010119-t1x9gknd 11151 21 . . . cord-010119-t1x9gknd 11152 1 This this DT cord-010119-t1x9gknd 11152 2 contact contact NN cord-010119-t1x9gknd 11152 3 ensures ensure VBZ cord-010119-t1x9gknd 11152 4 that that IN cord-010119-t1x9gknd 11152 5 if if IN cord-010119-t1x9gknd 11152 6 recruitment recruitment NN cord-010119-t1x9gknd 11152 7 is be VBZ cord-010119-t1x9gknd 11152 8 required require VBN cord-010119-t1x9gknd 11152 9 to to TO cord-010119-t1x9gknd 11152 10 obtain obtain VB cord-010119-t1x9gknd 11152 11 blood blood NN cord-010119-t1x9gknd 11152 12 for for IN cord-010119-t1x9gknd 11152 13 a a DT cord-010119-t1x9gknd 11152 14 patient patient NN cord-010119-t1x9gknd 11152 15 with with IN cord-010119-t1x9gknd 11152 16 a a DT cord-010119-t1x9gknd 11152 17 rare rare JJ cord-010119-t1x9gknd 11152 18 blood blood NN cord-010119-t1x9gknd 11152 19 need need NN cord-010119-t1x9gknd 11152 20 , , , cord-010119-t1x9gknd 11152 21 the the DT cord-010119-t1x9gknd 11152 22 donor donor NN cord-010119-t1x9gknd 11152 23 can can MD cord-010119-t1x9gknd 11152 24 be be VB cord-010119-t1x9gknd 11152 25 contacted contact VBN cord-010119-t1x9gknd 11152 26 by by IN cord-010119-t1x9gknd 11152 27 the the DT cord-010119-t1x9gknd 11152 28 collecting collecting NN cord-010119-t1x9gknd 11152 29 center center NN cord-010119-t1x9gknd 11152 30 to to TO cord-010119-t1x9gknd 11152 31 donate donate VB cord-010119-t1x9gknd 11152 32 . . . cord-010119-t1x9gknd 11153 1 This this DT cord-010119-t1x9gknd 11153 2 contact contact NN cord-010119-t1x9gknd 11153 3 is be VBZ cord-010119-t1x9gknd 11153 4 achieved achieve VBN cord-010119-t1x9gknd 11153 5 by by IN cord-010119-t1x9gknd 11153 6 ARDP ARDP NNP cord-010119-t1x9gknd 11153 7 sending send VBG cord-010119-t1x9gknd 11153 8 a a DT cord-010119-t1x9gknd 11153 9 contact contact NN cord-010119-t1x9gknd 11153 10 card card NN cord-010119-t1x9gknd 11153 11 by by IN cord-010119-t1x9gknd 11153 12 postal postal JJ cord-010119-t1x9gknd 11153 13 mail mail NN cord-010119-t1x9gknd 11153 14 twice twice RB cord-010119-t1x9gknd 11153 15 yearly yearly JJ cord-010119-t1x9gknd 11153 16 to to IN cord-010119-t1x9gknd 11153 17 all all DT cord-010119-t1x9gknd 11153 18 donors donor NNS cord-010119-t1x9gknd 11153 19 for for IN cord-010119-t1x9gknd 11153 20 whom whom WP cord-010119-t1x9gknd 11153 21 the the DT cord-010119-t1x9gknd 11153 22 ARDP ARDP NNP cord-010119-t1x9gknd 11153 23 has have VBZ cord-010119-t1x9gknd 11153 24 address address NN cord-010119-t1x9gknd 11153 25 demographics demographic NNS cord-010119-t1x9gknd 11153 26 . . . cord-010119-t1x9gknd 11154 1 Results/ Results/ . cord-010119-t1x9gknd 11155 1 Finding finding NN cord-010119-t1x9gknd 11155 2 : : : cord-010119-t1x9gknd 11156 1 The the DT cord-010119-t1x9gknd 11156 2 ARDP ARDP NNP cord-010119-t1x9gknd 11156 3 reports report VBZ cord-010119-t1x9gknd 11156 4 on on IN cord-010119-t1x9gknd 11156 5 the the DT cord-010119-t1x9gknd 11156 6 information information NN cord-010119-t1x9gknd 11156 7 obtained obtain VBN cord-010119-t1x9gknd 11156 8 from from IN cord-010119-t1x9gknd 11156 9 the the DT cord-010119-t1x9gknd 11156 10 contact contact NN cord-010119-t1x9gknd 11156 11 cards card NNS cord-010119-t1x9gknd 11156 12 returned return VBD cord-010119-t1x9gknd 11156 13 in in IN cord-010119-t1x9gknd 11156 14 the the DT cord-010119-t1x9gknd 11156 15 ARDP ARDP NNP cord-010119-t1x9gknd 11156 16 Annual Annual NNP cord-010119-t1x9gknd 11156 17 Activity Activity NNP cord-010119-t1x9gknd 11156 18 Report Report NNP cord-010119-t1x9gknd 11156 19 to to IN cord-010119-t1x9gknd 11156 20 the the DT cord-010119-t1x9gknd 11156 21 ARDP ARDP NNP cord-010119-t1x9gknd 11156 22 Members Members NNPS cord-010119-t1x9gknd 11156 23 at at IN cord-010119-t1x9gknd 11156 24 the the DT cord-010119-t1x9gknd 11156 25 AABB AABB NNP cord-010119-t1x9gknd 11156 26 Annual annual JJ cord-010119-t1x9gknd 11156 27 meeting meeting NN cord-010119-t1x9gknd 11156 28 . . . cord-010119-t1x9gknd 11157 1 Of of IN cord-010119-t1x9gknd 11157 2 the the DT cord-010119-t1x9gknd 11157 3 6398 6398 CD cord-010119-t1x9gknd 11157 4 ( ( -LRB- cord-010119-t1x9gknd 11157 5 9.7 9.7 CD cord-010119-t1x9gknd 11157 6 % % NN cord-010119-t1x9gknd 11157 7 of of IN cord-010119-t1x9gknd 11157 8 total total JJ cord-010119-t1x9gknd 11157 9 active active JJ cord-010119-t1x9gknd 11157 10 donors donor NNS cord-010119-t1x9gknd 11157 11 ) ) -RRB- cord-010119-t1x9gknd 11157 12 returned return VBD cord-010119-t1x9gknd 11157 13 contact contact NN cord-010119-t1x9gknd 11157 14 cards card NNS cord-010119-t1x9gknd 11157 15 alerting alert VBG cord-010119-t1x9gknd 11157 16 ARDP ARDP NNP cord-010119-t1x9gknd 11157 17 of of IN cord-010119-t1x9gknd 11157 18 changes change NNS cord-010119-t1x9gknd 11157 19 in in IN cord-010119-t1x9gknd 11157 20 calendar calendar NN cord-010119-t1x9gknd 11157 21 year year NN cord-010119-t1x9gknd 11157 22 2016 2016 CD cord-010119-t1x9gknd 11157 23 , , , cord-010119-t1x9gknd 11157 24 355 355 CD cord-010119-t1x9gknd 11157 25 ( ( -LRB- cord-010119-t1x9gknd 11157 26 5.5 5.5 CD cord-010119-t1x9gknd 11157 27 % % NN cord-010119-t1x9gknd 11157 28 ) ) -RRB- cord-010119-t1x9gknd 11157 29 were be VBD cord-010119-t1x9gknd 11157 30 donors donor NNS cord-010119-t1x9gknd 11157 31 moving move VBG cord-010119-t1x9gknd 11157 32 from from IN cord-010119-t1x9gknd 11157 33 one one CD cord-010119-t1x9gknd 11157 34 ARDP ARDP NNP cord-010119-t1x9gknd 11157 35 facility facility NN cord-010119-t1x9gknd 11157 36 to to IN cord-010119-t1x9gknd 11157 37 another another DT cord-010119-t1x9gknd 11157 38 , , , cord-010119-t1x9gknd 11157 39 1369 1369 CD cord-010119-t1x9gknd 11157 40 ( ( -LRB- cord-010119-t1x9gknd 11157 41 21.4 21.4 CD cord-010119-t1x9gknd 11157 42 % % NN cord-010119-t1x9gknd 11157 43 ) ) -RRB- cord-010119-t1x9gknd 11158 1 were be VBD cord-010119-t1x9gknd 11158 2 donors donor NNS cord-010119-t1x9gknd 11158 3 no no RB cord-010119-t1x9gknd 11158 4 longer long RBR cord-010119-t1x9gknd 11158 5 eligible eligible JJ cord-010119-t1x9gknd 11158 6 to to TO cord-010119-t1x9gknd 11158 7 donate donate VB cord-010119-t1x9gknd 11158 8 , , , cord-010119-t1x9gknd 11158 9 and and CC cord-010119-t1x9gknd 11158 10 an an DT cord-010119-t1x9gknd 11158 11 additional additional JJ cord-010119-t1x9gknd 11158 12 4324 4324 CD cord-010119-t1x9gknd 11158 13 ( ( -LRB- cord-010119-t1x9gknd 11158 14 68.4 68.4 CD cord-010119-t1x9gknd 11158 15 % % NN cord-010119-t1x9gknd 11158 16 ) ) -RRB- cord-010119-t1x9gknd 11158 17 were be VBD cord-010119-t1x9gknd 11158 18 address address NN cord-010119-t1x9gknd 11158 19 changes change NNS cord-010119-t1x9gknd 11158 20 . . . cord-010119-t1x9gknd 11159 1 Other other JJ cord-010119-t1x9gknd 11159 2 changes change NNS cord-010119-t1x9gknd 11159 3 were be VBD cord-010119-t1x9gknd 11159 4 115 115 CD cord-010119-t1x9gknd 11159 5 ( ( -LRB- cord-010119-t1x9gknd 11159 6 1.8 1.8 CD cord-010119-t1x9gknd 11159 7 % % NN cord-010119-t1x9gknd 11159 8 ) ) -RRB- cord-010119-t1x9gknd 11159 9 reactivated reactivate VBN cord-010119-t1x9gknd 11159 10 donors donor NNS cord-010119-t1x9gknd 11159 11 and and CC cord-010119-t1x9gknd 11159 12 235 235 CD cord-010119-t1x9gknd 11159 13 ( ( -LRB- cord-010119-t1x9gknd 11159 14 3.5 3.5 CD cord-010119-t1x9gknd 11159 15 % % NN cord-010119-t1x9gknd 11159 16 ) ) -RRB- cord-010119-t1x9gknd 11159 17 donors donor NNS cord-010119-t1x9gknd 11159 18 who who WP cord-010119-t1x9gknd 11159 19 we -PRON- PRP cord-010119-t1x9gknd 11159 20 were be VBD cord-010119-t1x9gknd 11159 21 notified notify VBN cord-010119-t1x9gknd 11159 22 were be VBD cord-010119-t1x9gknd 11159 23 deceased deceased JJ cord-010119-t1x9gknd 11159 24 , , , cord-010119-t1x9gknd 11159 25 or or CC cord-010119-t1x9gknd 11159 26 did do VBD cord-010119-t1x9gknd 11159 27 not not RB cord-010119-t1x9gknd 11159 28 want want VB cord-010119-t1x9gknd 11159 29 to to TO cord-010119-t1x9gknd 11159 30 be be VB cord-010119-t1x9gknd 11159 31 listed list VBN cord-010119-t1x9gknd 11159 32 in in IN cord-010119-t1x9gknd 11159 33 the the DT cord-010119-t1x9gknd 11159 34 ARDP ARDP NNP cord-010119-t1x9gknd 11159 35 . . . cord-010119-t1x9gknd 11160 1 In in IN cord-010119-t1x9gknd 11160 2 2016 2016 CD cord-010119-t1x9gknd 11160 3 , , , cord-010119-t1x9gknd 11160 4 5390 5390 CD cord-010119-t1x9gknd 11160 5 new new JJ cord-010119-t1x9gknd 11160 6 rare rare JJ cord-010119-t1x9gknd 11160 7 donors donor NNS cord-010119-t1x9gknd 11160 8 were be VBD cord-010119-t1x9gknd 11160 9 submitted submit VBN cord-010119-t1x9gknd 11160 10 to to IN cord-010119-t1x9gknd 11160 11 ARDP ARDP NNP cord-010119-t1x9gknd 11160 12 for for IN cord-010119-t1x9gknd 11160 13 registration registration NN cord-010119-t1x9gknd 11160 14 . . . cord-010119-t1x9gknd 11161 1 The the DT cord-010119-t1x9gknd 11161 2 number number NN cord-010119-t1x9gknd 11161 3 of of IN cord-010119-t1x9gknd 11161 4 donors donor NNS cord-010119-t1x9gknd 11161 5 that that WDT cord-010119-t1x9gknd 11161 6 could could MD cord-010119-t1x9gknd 11161 7 potentially potentially RB cord-010119-t1x9gknd 11161 8 be be VB cord-010119-t1x9gknd 11161 9 lost lose VBN cord-010119-t1x9gknd 11161 10 to to TO cord-010119-t1x9gknd 11161 11 follow follow VB cord-010119-t1x9gknd 11161 12 - - HYPH cord-010119-t1x9gknd 11161 13 up up NN cord-010119-t1x9gknd 11161 14 in in IN cord-010119-t1x9gknd 11161 15 2016 2016 CD cord-010119-t1x9gknd 11161 16 was be VBD cord-010119-t1x9gknd 11161 17 4709 4709 CD cord-010119-t1x9gknd 11161 18 ( ( -LRB- cord-010119-t1x9gknd 11161 19 355 355 CD cord-010119-t1x9gknd 11161 20 1 1 CD cord-010119-t1x9gknd 11161 21 4324 4324 CD cord-010119-t1x9gknd 11161 22 ) ) -RRB- cord-010119-t1x9gknd 11161 23 , , , cord-010119-t1x9gknd 11161 24 which which WDT cord-010119-t1x9gknd 11161 25 would would MD cord-010119-t1x9gknd 11161 26 be be VB cord-010119-t1x9gknd 11161 27 87.4 87.4 CD cord-010119-t1x9gknd 11161 28 % % NN cord-010119-t1x9gknd 11161 29 of of IN cord-010119-t1x9gknd 11161 30 the the DT cord-010119-t1x9gknd 11161 31 new new JJ cord-010119-t1x9gknd 11161 32 donors donor NNS cord-010119-t1x9gknd 11161 33 submitted submit VBN cord-010119-t1x9gknd 11161 34 . . . cord-010119-t1x9gknd 11162 1 Conclusion conclusion NN cord-010119-t1x9gknd 11162 2 : : : cord-010119-t1x9gknd 11163 1 With with IN cord-010119-t1x9gknd 11163 2 nearly nearly RB cord-010119-t1x9gknd 11163 3 a a DT cord-010119-t1x9gknd 11163 4 10 10 CD cord-010119-t1x9gknd 11163 5 % % NN cord-010119-t1x9gknd 11163 6 response response NN cord-010119-t1x9gknd 11163 7 rate rate NN cord-010119-t1x9gknd 11163 8 for for IN cord-010119-t1x9gknd 11163 9 donors donor NNS cord-010119-t1x9gknd 11163 10 receiving receive VBG cord-010119-t1x9gknd 11163 11 the the DT cord-010119-t1x9gknd 11163 12 mailed mail VBN cord-010119-t1x9gknd 11163 13 contact contact NN cord-010119-t1x9gknd 11163 14 cards card NNS cord-010119-t1x9gknd 11163 15 , , , cord-010119-t1x9gknd 11163 16 it -PRON- PRP cord-010119-t1x9gknd 11163 17 is be VBZ cord-010119-t1x9gknd 11163 18 clear clear JJ cord-010119-t1x9gknd 11163 19 that that IN cord-010119-t1x9gknd 11163 20 rare rare JJ cord-010119-t1x9gknd 11163 21 donors donor NNS cord-010119-t1x9gknd 11163 22 ( ( -LRB- cord-010119-t1x9gknd 11163 23 and and CC cord-010119-t1x9gknd 11163 24 their -PRON- PRP$ cord-010119-t1x9gknd 11163 25 families family NNS cord-010119-t1x9gknd 11163 26 ) ) -RRB- cord-010119-t1x9gknd 11163 27 are be VBP cord-010119-t1x9gknd 11163 28 responsive responsive JJ cord-010119-t1x9gknd 11163 29 to to IN cord-010119-t1x9gknd 11163 30 the the DT cord-010119-t1x9gknd 11163 31 ARDP ARDP NNP cord-010119-t1x9gknd 11163 32 contact contact NN cord-010119-t1x9gknd 11163 33 card card NN cord-010119-t1x9gknd 11163 34 , , , cord-010119-t1x9gknd 11163 35 and and CC cord-010119-t1x9gknd 11163 36 inform inform VB cord-010119-t1x9gknd 11163 37 ARDP ARDP NNP cord-010119-t1x9gknd 11163 38 of of IN cord-010119-t1x9gknd 11163 39 address address NN cord-010119-t1x9gknd 11163 40 changes change NNS cord-010119-t1x9gknd 11163 41 and and CC cord-010119-t1x9gknd 11163 42 changes change NNS cord-010119-t1x9gknd 11163 43 in in IN cord-010119-t1x9gknd 11163 44 their -PRON- PRP$ cord-010119-t1x9gknd 11163 45 health health NN cord-010119-t1x9gknd 11163 46 status status NN cord-010119-t1x9gknd 11163 47 that that WDT cord-010119-t1x9gknd 11163 48 affects affect VBZ cord-010119-t1x9gknd 11163 49 their -PRON- PRP$ cord-010119-t1x9gknd 11163 50 ability ability NN cord-010119-t1x9gknd 11163 51 to to TO cord-010119-t1x9gknd 11163 52 donate donate VB cord-010119-t1x9gknd 11163 53 . . . cord-010119-t1x9gknd 11164 1 This this DT cord-010119-t1x9gknd 11164 2 is be VBZ cord-010119-t1x9gknd 11164 3 evidence evidence NN cord-010119-t1x9gknd 11164 4 of of IN cord-010119-t1x9gknd 11164 5 the the DT cord-010119-t1x9gknd 11164 6 importance importance NN cord-010119-t1x9gknd 11164 7 of of IN cord-010119-t1x9gknd 11164 8 the the DT cord-010119-t1x9gknd 11164 9 card card NN cord-010119-t1x9gknd 11164 10 in in IN cord-010119-t1x9gknd 11164 11 ensuring ensure VBG cord-010119-t1x9gknd 11164 12 correct correct JJ cord-010119-t1x9gknd 11164 13 donor donor NN cord-010119-t1x9gknd 11164 14 contact contact NN cord-010119-t1x9gknd 11164 15 information information NN cord-010119-t1x9gknd 11164 16 . . . cord-010119-t1x9gknd 11165 1 In in IN cord-010119-t1x9gknd 11165 2 2016 2016 CD cord-010119-t1x9gknd 11165 3 , , , cord-010119-t1x9gknd 11165 4 4709 4709 CD cord-010119-t1x9gknd 11165 5 donors donor NNS cord-010119-t1x9gknd 11165 6 changed change VBD cord-010119-t1x9gknd 11165 7 their -PRON- PRP$ cord-010119-t1x9gknd 11165 8 addresses address NNS cord-010119-t1x9gknd 11165 9 which which WDT cord-010119-t1x9gknd 11165 10 often often RB cord-010119-t1x9gknd 11165 11 are be VBP cord-010119-t1x9gknd 11165 12 not not RB cord-010119-t1x9gknd 11165 13 known know VBN cord-010119-t1x9gknd 11165 14 to to IN cord-010119-t1x9gknd 11165 15 the the DT cord-010119-t1x9gknd 11165 16 collecting collecting NN cord-010119-t1x9gknd 11165 17 facility facility NN cord-010119-t1x9gknd 11165 18 until until IN cord-010119-t1x9gknd 11165 19 the the DT cord-010119-t1x9gknd 11165 20 donors donor NNS cord-010119-t1x9gknd 11165 21 donates donate VBZ cord-010119-t1x9gknd 11165 22 again again RB cord-010119-t1x9gknd 11165 23 , , , cord-010119-t1x9gknd 11165 24 after after IN cord-010119-t1x9gknd 11165 25 their -PRON- PRP$ cord-010119-t1x9gknd 11165 26 move move NN cord-010119-t1x9gknd 11165 27 . . . cord-010119-t1x9gknd 11166 1 The the DT cord-010119-t1x9gknd 11166 2 ARDP ARDP NNP cord-010119-t1x9gknd 11166 3 contact contact NN cord-010119-t1x9gknd 11166 4 card card NN cord-010119-t1x9gknd 11166 5 is be VBZ cord-010119-t1x9gknd 11166 6 effective effective JJ cord-010119-t1x9gknd 11166 7 in in IN cord-010119-t1x9gknd 11166 8 retaining retain VBG cord-010119-t1x9gknd 11166 9 the the DT cord-010119-t1x9gknd 11166 10 relationship relationship NN cord-010119-t1x9gknd 11166 11 with with IN cord-010119-t1x9gknd 11166 12 the the DT cord-010119-t1x9gknd 11166 13 ARDP ARDP NNP cord-010119-t1x9gknd 11166 14 registered register VBN cord-010119-t1x9gknd 11166 15 donors donor NNS cord-010119-t1x9gknd 11166 16 and and CC cord-010119-t1x9gknd 11166 17 keeps keep VBZ cord-010119-t1x9gknd 11166 18 the the DT cord-010119-t1x9gknd 11166 19 address address NN cord-010119-t1x9gknd 11166 20 information information NN cord-010119-t1x9gknd 11166 21 of of IN cord-010119-t1x9gknd 11166 22 rare rare JJ cord-010119-t1x9gknd 11166 23 donors donor NNS cord-010119-t1x9gknd 11166 24 current current JJ cord-010119-t1x9gknd 11166 25 . . . cord-010119-t1x9gknd 11167 1 Workflow workflow NN cord-010119-t1x9gknd 11167 2 Comparison comparison NN cord-010119-t1x9gknd 11167 3 of of IN cord-010119-t1x9gknd 11167 4 Two two CD cord-010119-t1x9gknd 11167 5 Gel Gel NNP cord-010119-t1x9gknd 11167 6 Analyzers analyzer NNS cord-010119-t1x9gknd 11167 7 in in IN cord-010119-t1x9gknd 11167 8 a a DT cord-010119-t1x9gknd 11167 9 Large Large NNP cord-010119-t1x9gknd 11167 10 Transfusion Transfusion NNP cord-010119-t1x9gknd 11167 11 Service Service NNP cord-010119-t1x9gknd 11167 12 J J NNP cord-010119-t1x9gknd 11167 13 Peter Peter NNP cord-010119-t1x9gknd 11167 14 Pelletier Pelletier NNP cord-010119-t1x9gknd 11167 15 * * NFP cord-010119-t1x9gknd 11167 16 1 1 CD cord-010119-t1x9gknd 11167 17 , , , cord-010119-t1x9gknd 11167 18 Barbara Barbara NNP cord-010119-t1x9gknd 11167 19 J J NNP cord-010119-t1x9gknd 11167 20 Bachman Bachman NNP cord-010119-t1x9gknd 11167 21 2 2 CD cord-010119-t1x9gknd 11167 22 , , , cord-010119-t1x9gknd 11167 23 Mike Mike NNP cord-010119-t1x9gknd 11167 24 Leamy Leamy NNP cord-010119-t1x9gknd 11167 25 2 2 CD cord-010119-t1x9gknd 11167 26 , , , cord-010119-t1x9gknd 11167 27 Susan Susan NNP cord-010119-t1x9gknd 11167 28 Olson Olson NNP cord-010119-t1x9gknd 11167 29 2 2 CD cord-010119-t1x9gknd 11167 30 and and CC cord-010119-t1x9gknd 11167 31 Candace Candace NNP cord-010119-t1x9gknd 11167 32 Williams Williams NNP cord-010119-t1x9gknd 11167 33 2 2 CD cord-010119-t1x9gknd 11167 34 . . . cord-010119-t1x9gknd 11168 1 1 1 CD cord-010119-t1x9gknd 11168 2 University University NNP cord-010119-t1x9gknd 11168 3 of of IN cord-010119-t1x9gknd 11168 4 Florida Florida NNP cord-010119-t1x9gknd 11168 5 College College NNP cord-010119-t1x9gknd 11168 6 of of IN cord-010119-t1x9gknd 11168 7 Medicine Medicine NNP cord-010119-t1x9gknd 11168 8 , , , cord-010119-t1x9gknd 11168 9 2 2 CD cord-010119-t1x9gknd 11168 10 Bio Bio NNP cord-010119-t1x9gknd 11168 11 - - HYPH cord-010119-t1x9gknd 11168 12 Rad Rad NNP cord-010119-t1x9gknd 11168 13 Laboratories Laboratories NNP cord-010119-t1x9gknd 11168 14 Background Background NNP cord-010119-t1x9gknd 11168 15 / / SYM cord-010119-t1x9gknd 11168 16 Case Case NNP cord-010119-t1x9gknd 11168 17 Studies Studies NNPS cord-010119-t1x9gknd 11168 18 : : : cord-010119-t1x9gknd 11169 1 Vendor vendor NN cord-010119-t1x9gknd 11169 2 - - HYPH cord-010119-t1x9gknd 11169 3 assisted assist VBN cord-010119-t1x9gknd 11169 4 workflow workflow NN cord-010119-t1x9gknd 11169 5 studies study NNS cord-010119-t1x9gknd 11169 6 are be VBP cord-010119-t1x9gknd 11169 7 becoming become VBG cord-010119-t1x9gknd 11169 8 more more RBR cord-010119-t1x9gknd 11169 9 popular popular JJ cord-010119-t1x9gknd 11169 10 as as IN cord-010119-t1x9gknd 11169 11 analyzer analyzer NN cord-010119-t1x9gknd 11169 12 choices choice NNS cord-010119-t1x9gknd 11169 13 and and CC cord-010119-t1x9gknd 11169 14 capabilities capability NNS cord-010119-t1x9gknd 11169 15 vary vary VBP cord-010119-t1x9gknd 11169 16 in in IN cord-010119-t1x9gknd 11169 17 the the DT cord-010119-t1x9gknd 11169 18 market market NN cord-010119-t1x9gknd 11169 19 . . . cord-010119-t1x9gknd 11170 1 The the DT cord-010119-t1x9gknd 11170 2 purpose purpose NN cord-010119-t1x9gknd 11170 3 of of IN cord-010119-t1x9gknd 11170 4 this this DT cord-010119-t1x9gknd 11170 5 study study NN cord-010119-t1x9gknd 11170 6 was be VBD cord-010119-t1x9gknd 11170 7 to to TO cord-010119-t1x9gknd 11170 8 evaluate evaluate VB cord-010119-t1x9gknd 11170 9 the the DT cord-010119-t1x9gknd 11170 10 ProVue ProVue NNP cord-010119-t1x9gknd 11170 11 ( ( -LRB- cord-010119-t1x9gknd 11170 12 Ortho Ortho NNP cord-010119-t1x9gknd 11170 13 Clinical Clinical NNP cord-010119-t1x9gknd 11170 14 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 11170 15 ) ) -RRB- cord-010119-t1x9gknd 11170 16 against against IN cord-010119-t1x9gknd 11170 17 the the DT cord-010119-t1x9gknd 11170 18 IH-1000 IH-1000 NNP cord-010119-t1x9gknd 11171 1 ( ( -LRB- cord-010119-t1x9gknd 11171 2 Bio Bio NNP cord-010119-t1x9gknd 11171 3 - - HYPH cord-010119-t1x9gknd 11171 4 Rad Rad NNP cord-010119-t1x9gknd 11171 5 Laboratories Laboratories NNP cord-010119-t1x9gknd 11171 6 , , , cord-010119-t1x9gknd 11171 7 Inc. Inc. NNP cord-010119-t1x9gknd 11171 8 ) ) -RRB- cord-010119-t1x9gknd 11171 9 in in IN cord-010119-t1x9gknd 11171 10 a a DT cord-010119-t1x9gknd 11171 11 large large JJ cord-010119-t1x9gknd 11171 12 volume volume NN cord-010119-t1x9gknd 11171 13 transfusion transfusion NN cord-010119-t1x9gknd 11171 14 service service NN cord-010119-t1x9gknd 11171 15 using use VBG cord-010119-t1x9gknd 11171 16 LEAN lean JJ cord-010119-t1x9gknd 11171 17 process process NN cord-010119-t1x9gknd 11171 18 flow flow NN cord-010119-t1x9gknd 11171 19 . . . cord-010119-t1x9gknd 11172 1 Study Study NNP cord-010119-t1x9gknd 11172 2 Design Design NNP cord-010119-t1x9gknd 11172 3 / / SYM cord-010119-t1x9gknd 11172 4 Method method NN cord-010119-t1x9gknd 11172 5 : : : cord-010119-t1x9gknd 11173 1 Twenty twenty CD cord-010119-t1x9gknd 11173 2 - - HYPH cord-010119-t1x9gknd 11173 3 two two CD cord-010119-t1x9gknd 11173 4 ( ( -LRB- cord-010119-t1x9gknd 11173 5 22 22 CD cord-010119-t1x9gknd 11173 6 ) ) -RRB- cord-010119-t1x9gknd 11173 7 runs run NNS cord-010119-t1x9gknd 11173 8 of of IN cord-010119-t1x9gknd 11173 9 one one CD cord-010119-t1x9gknd 11173 10 to to TO cord-010119-t1x9gknd 11173 11 six six CD cord-010119-t1x9gknd 11173 12 ( ( -LRB- cord-010119-t1x9gknd 11173 13 6 6 CD cord-010119-t1x9gknd 11173 14 ) ) -RRB- cord-010119-t1x9gknd 11173 15 samples sample NNS cord-010119-t1x9gknd 11173 16 per per IN cord-010119-t1x9gknd 11173 17 run run NN cord-010119-t1x9gknd 11173 18 were be VBD cord-010119-t1x9gknd 11173 19 observed observe VBN cord-010119-t1x9gknd 11173 20 for for IN cord-010119-t1x9gknd 11173 21 two two CD cord-010119-t1x9gknd 11173 22 Ortho Ortho NNP cord-010119-t1x9gknd 11173 23 ProVues ProVues NNP cord-010119-t1x9gknd 11173 24 alternating alternate VBG cord-010119-t1x9gknd 11173 25 testing testing NN cord-010119-t1x9gknd 11173 26 at at IN cord-010119-t1x9gknd 11173 27 a a DT cord-010119-t1x9gknd 11173 28 large large JJ cord-010119-t1x9gknd 11173 29 Transfusion Transfusion NNP cord-010119-t1x9gknd 11173 30 Service Service NNP cord-010119-t1x9gknd 11173 31 performing perform VBG cord-010119-t1x9gknd 11173 32 153,000 153,000 CD cord-010119-t1x9gknd 11173 33 Types type NNS cord-010119-t1x9gknd 11173 34 , , , cord-010119-t1x9gknd 11173 35 Screens Screens NNPS cord-010119-t1x9gknd 11173 36 , , , cord-010119-t1x9gknd 11173 37 Type type NN cord-010119-t1x9gknd 11173 38 & & CC cord-010119-t1x9gknd 11173 39 Screens Screens NNPS cord-010119-t1x9gknd 11173 40 ( ( -LRB- cord-010119-t1x9gknd 11173 41 T&S T&S NNP cord-010119-t1x9gknd 11173 42 ) ) -RRB- cord-010119-t1x9gknd 11173 43 annually annually RB cord-010119-t1x9gknd 11173 44 . . . cord-010119-t1x9gknd 11174 1 The the DT cord-010119-t1x9gknd 11174 2 workflow workflow NN cord-010119-t1x9gknd 11174 3 patterns pattern NNS cord-010119-t1x9gknd 11174 4 observed observe VBN cord-010119-t1x9gknd 11174 5 were be VBD cord-010119-t1x9gknd 11174 6 then then RB cord-010119-t1x9gknd 11174 7 repeated repeat VBN cord-010119-t1x9gknd 11174 8 on on IN cord-010119-t1x9gknd 11174 9 the the DT cord-010119-t1x9gknd 11174 10 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11174 11 and and CC cord-010119-t1x9gknd 11174 12 compared compare VBN cord-010119-t1x9gknd 11174 13 . . . cord-010119-t1x9gknd 11175 1 Each each DT cord-010119-t1x9gknd 11175 2 process process NN cord-010119-t1x9gknd 11175 3 was be VBD cord-010119-t1x9gknd 11175 4 mapped map VBN cord-010119-t1x9gknd 11175 5 in in IN cord-010119-t1x9gknd 11175 6 detail detail NN cord-010119-t1x9gknd 11175 7 by by IN cord-010119-t1x9gknd 11175 8 direct direct JJ cord-010119-t1x9gknd 11175 9 observation observation NN cord-010119-t1x9gknd 11175 10 using use VBG cord-010119-t1x9gknd 11175 11 Process Process NNP cord-010119-t1x9gknd 11175 12 Modellar Modellar NNP cord-010119-t1x9gknd 11175 13 APP APP NNP cord-010119-t1x9gknd 11175 14 ( ( -LRB- cord-010119-t1x9gknd 11175 15 iPAD iPAD NNP cord-010119-t1x9gknd 11175 16 ) ) -RRB- cord-010119-t1x9gknd 11175 17 . . . cord-010119-t1x9gknd 11176 1 The the DT cord-010119-t1x9gknd 11176 2 evaluation evaluation NN cord-010119-t1x9gknd 11176 3 started start VBD cord-010119-t1x9gknd 11176 4 at at IN cord-010119-t1x9gknd 11176 5 sample sample NN cord-010119-t1x9gknd 11176 6 centrifugation centrifugation NN cord-010119-t1x9gknd 11176 7 completion completion NN cord-010119-t1x9gknd 11176 8 and and CC cord-010119-t1x9gknd 11176 9 ended end VBD cord-010119-t1x9gknd 11176 10 with with IN cord-010119-t1x9gknd 11176 11 results result NNS cord-010119-t1x9gknd 11176 12 sent send VBN cord-010119-t1x9gknd 11176 13 from from IN cord-010119-t1x9gknd 11176 14 analyzer analyzer NN cord-010119-t1x9gknd 11176 15 to to IN cord-010119-t1x9gknd 11176 16 LIS LIS NNP cord-010119-t1x9gknd 11176 17 ( ( -LRB- cord-010119-t1x9gknd 11176 18 Lab Lab NNP cord-010119-t1x9gknd 11176 19 Information Information NNP cord-010119-t1x9gknd 11176 20 System System NNP cord-010119-t1x9gknd 11176 21 ) ) -RRB- cord-010119-t1x9gknd 11176 22 . . . cord-010119-t1x9gknd 11177 1 Each each DT cord-010119-t1x9gknd 11177 2 was be VBD cord-010119-t1x9gknd 11177 3 evaluated evaluate VBN cord-010119-t1x9gknd 11177 4 for for IN cord-010119-t1x9gknd 11177 5 quality quality NN cord-010119-t1x9gknd 11177 6 ( ( -LRB- cord-010119-t1x9gknd 11177 7 testing testing NN cord-010119-t1x9gknd 11177 8 process process NN cord-010119-t1x9gknd 11177 9 steps step NNS cord-010119-t1x9gknd 11177 10 , , , cord-010119-t1x9gknd 11177 11 biohazardous biohazardous JJ cord-010119-t1x9gknd 11177 12 exposure exposure NN cord-010119-t1x9gknd 11177 13 episodes episode NNS cord-010119-t1x9gknd 11177 14 , , , cord-010119-t1x9gknd 11177 15 and and CC cord-010119-t1x9gknd 11177 16 maintenance maintenance NN cord-010119-t1x9gknd 11177 17 tasks task NNS cord-010119-t1x9gknd 11177 18 ) ) -RRB- cord-010119-t1x9gknd 11177 19 , , , cord-010119-t1x9gknd 11177 20 speed speed NN cord-010119-t1x9gknd 11177 21 ( ( -LRB- cord-010119-t1x9gknd 11177 22 operator operator NN cord-010119-t1x9gknd 11177 23 / / SYM cord-010119-t1x9gknd 11177 24 analyzer analyzer NN cord-010119-t1x9gknd 11177 25 time time NN cord-010119-t1x9gknd 11177 26 ) ) -RRB- cord-010119-t1x9gknd 11177 27 and and CC cord-010119-t1x9gknd 11177 28 cost cost NN cord-010119-t1x9gknd 11177 29 ( ( -LRB- cord-010119-t1x9gknd 11177 30 testing testing NN cord-010119-t1x9gknd 11177 31 / / SYM cord-010119-t1x9gknd 11177 32 maintenance maintenance NN cord-010119-t1x9gknd 11177 33 personnel personnel NNS cord-010119-t1x9gknd 11177 34 hours hour NNS cord-010119-t1x9gknd 11177 35 recaptured recapture VBN cord-010119-t1x9gknd 11177 36 ) ) -RRB- cord-010119-t1x9gknd 11177 37 . . . cord-010119-t1x9gknd 11178 1 Time Time NNP cord-010119-t1x9gknd 11178 2 studies study NNS cord-010119-t1x9gknd 11178 3 were be VBD cord-010119-t1x9gknd 11178 4 analyzed analyze VBN cord-010119-t1x9gknd 11178 5 using use VBG cord-010119-t1x9gknd 11178 6 Minitab Minitab NNP cord-010119-t1x9gknd 11178 7 v17 v17 NNP cord-010119-t1x9gknd 11178 8 , , , cord-010119-t1x9gknd 11178 9 and and CC cord-010119-t1x9gknd 11178 10 statistical statistical JJ cord-010119-t1x9gknd 11178 11 significance significance NN cord-010119-t1x9gknd 11178 12 was be VBD cord-010119-t1x9gknd 11178 13 assessed assess VBN cord-010119-t1x9gknd 11178 14 using use VBG cord-010119-t1x9gknd 11178 15 the the DT cord-010119-t1x9gknd 11178 16 paired paired JJ cord-010119-t1x9gknd 11178 17 t t NN cord-010119-t1x9gknd 11178 18 - - HYPH cord-010119-t1x9gknd 11178 19 test test NN cord-010119-t1x9gknd 11178 20 , , , cord-010119-t1x9gknd 11178 21 with with IN cord-010119-t1x9gknd 11178 22 p p NN cord-010119-t1x9gknd 11178 23 values value NNS cord-010119-t1x9gknd 11178 24 of of IN cord-010119-t1x9gknd 11178 25 < < NNP cord-010119-t1x9gknd 11178 26 0.05 0.05 CD cord-010119-t1x9gknd 11178 27 considered consider VBN cord-010119-t1x9gknd 11178 28 significant significant JJ cord-010119-t1x9gknd 11178 29 . . . cord-010119-t1x9gknd 11179 1 Regardless regardless RB cord-010119-t1x9gknd 11179 2 of of IN cord-010119-t1x9gknd 11179 3 quality quality NN cord-010119-t1x9gknd 11179 4 or or CC cord-010119-t1x9gknd 11179 5 speed speed NN cord-010119-t1x9gknd 11179 6 metrics metric NNS cord-010119-t1x9gknd 11179 7 evaluated evaluate VBN cord-010119-t1x9gknd 11179 8 , , , cord-010119-t1x9gknd 11179 9 the the DT cord-010119-t1x9gknd 11179 10 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11179 11 demonstrated demonstrate VBD cord-010119-t1x9gknd 11179 12 a a DT cord-010119-t1x9gknd 11179 13 significant significant JJ cord-010119-t1x9gknd 11179 14 reduction reduction NN cord-010119-t1x9gknd 11179 15 ( ( -LRB- cord-010119-t1x9gknd 11179 16 improvement improvement NN cord-010119-t1x9gknd 11179 17 ) ) -RRB- cord-010119-t1x9gknd 11179 18 in in IN cord-010119-t1x9gknd 11179 19 process process NN cord-010119-t1x9gknd 11179 20 steps step NNS cord-010119-t1x9gknd 11179 21 and and CC cord-010119-t1x9gknd 11179 22 associated associate VBD cord-010119-t1x9gknd 11179 23 times time NNS cord-010119-t1x9gknd 11179 24 when when WRB cord-010119-t1x9gknd 11179 25 compared compare VBN cord-010119-t1x9gknd 11179 26 against against IN cord-010119-t1x9gknd 11179 27 the the DT cord-010119-t1x9gknd 11179 28 Ortho Ortho NNP cord-010119-t1x9gknd 11179 29 ProVue ProVue NNP cord-010119-t1x9gknd 11179 30 ( ( -LRB- cord-010119-t1x9gknd 11179 31 p p NN cord-010119-t1x9gknd 11179 32 < < XX cord-010119-t1x9gknd 11179 33 0.001 0.001 CD cord-010119-t1x9gknd 11179 34 ) ) -RRB- cord-010119-t1x9gknd 11179 35 . . . cord-010119-t1x9gknd 11180 1 IH-1000 IH-1000 NNP cord-010119-t1x9gknd 11180 2 process process NN cord-010119-t1x9gknd 11180 3 steps step NNS cord-010119-t1x9gknd 11180 4 and and CC cord-010119-t1x9gknd 11180 5 time time NN cord-010119-t1x9gknd 11180 6 studies study NNS cord-010119-t1x9gknd 11180 7 addressed address VBN cord-010119-t1x9gknd 11180 8 in in IN cord-010119-t1x9gknd 11180 9 the the DT cord-010119-t1x9gknd 11180 10 table table NN cord-010119-t1x9gknd 11180 11 below below RB cord-010119-t1x9gknd 11180 12 did do VBD cord-010119-t1x9gknd 11180 13 not not RB cord-010119-t1x9gknd 11180 14 account account VB cord-010119-t1x9gknd 11180 15 for for IN cord-010119-t1x9gknd 11180 16 the the DT cord-010119-t1x9gknd 11180 17 IH-1000 IH-1000 NNP cord-010119-t1x9gknd 11180 18 reagent reagent NN cord-010119-t1x9gknd 11180 19 storage storage NN cord-010119-t1x9gknd 11180 20 capacity capacity NN cord-010119-t1x9gknd 11180 21 . . . cord-010119-t1x9gknd 11181 1 In in IN cord-010119-t1x9gknd 11181 2 reality reality NN cord-010119-t1x9gknd 11181 3 , , , cord-010119-t1x9gknd 11181 4 the the DT cord-010119-t1x9gknd 11181 5 improvements improvement NNS cord-010119-t1x9gknd 11181 6 would would MD cord-010119-t1x9gknd 11181 7 be be VB cord-010119-t1x9gknd 11181 8 greater great JJR cord-010119-t1x9gknd 11181 9 than than IN cord-010119-t1x9gknd 11181 10 what what WP cord-010119-t1x9gknd 11181 11 was be VBD cord-010119-t1x9gknd 11181 12 displayed display VBN cord-010119-t1x9gknd 11181 13 here here RB cord-010119-t1x9gknd 11181 14 in in IN cord-010119-t1x9gknd 11181 15 a a DT cord-010119-t1x9gknd 11181 16 real real JJ cord-010119-t1x9gknd 11181 17 - - HYPH cord-010119-t1x9gknd 11181 18 life life NN cord-010119-t1x9gknd 11181 19 operation operation NN cord-010119-t1x9gknd 11181 20 . . . cord-010119-t1x9gknd 11182 1 Evaluating evaluate VBG cord-010119-t1x9gknd 11182 2 the the DT cord-010119-t1x9gknd 11182 3 total total JJ cord-010119-t1x9gknd 11182 4 number number NN cord-010119-t1x9gknd 11182 5 of of IN cord-010119-t1x9gknd 11182 6 maintenance maintenance NN cord-010119-t1x9gknd 11182 7 tasks task NNS cord-010119-t1x9gknd 11182 8 required require VBN cord-010119-t1x9gknd 11182 9 annually annually RB cord-010119-t1x9gknd 11182 10 , , , cord-010119-t1x9gknd 11182 11 as as RB cord-010119-t1x9gknd 11182 12 well well RB cord-010119-t1x9gknd 11182 13 as as IN cord-010119-t1x9gknd 11182 14 the the DT cord-010119-t1x9gknd 11182 15 times time NNS cord-010119-t1x9gknd 11182 16 associated associate VBN cord-010119-t1x9gknd 11182 17 with with IN cord-010119-t1x9gknd 11182 18 maintenance maintenance NN cord-010119-t1x9gknd 11182 19 performance performance NN cord-010119-t1x9gknd 11182 20 , , , cord-010119-t1x9gknd 11182 21 there there EX cord-010119-t1x9gknd 11182 22 was be VBD cord-010119-t1x9gknd 11182 23 a a DT cord-010119-t1x9gknd 11182 24 significant significant JJ cord-010119-t1x9gknd 11182 25 reduction reduction NN cord-010119-t1x9gknd 11182 26 on on IN cord-010119-t1x9gknd 11182 27 the the DT cord-010119-t1x9gknd 11182 28 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11182 29 ( ( -LRB- cord-010119-t1x9gknd 11182 30 77 77 CD cord-010119-t1x9gknd 11182 31 % % NN cord-010119-t1x9gknd 11182 32 reduction reduction NN cord-010119-t1x9gknd 11182 33 , , , cord-010119-t1x9gknd 11182 34 a a DT cord-010119-t1x9gknd 11182 35 difference difference NN cord-010119-t1x9gknd 11182 36 of of IN cord-010119-t1x9gknd 11182 37 43 43 CD cord-010119-t1x9gknd 11182 38 hours hour NNS cord-010119-t1x9gknd 11182 39 / / SYM cord-010119-t1x9gknd 11182 40 year year NN cord-010119-t1x9gknd 11182 41 ) ) -RRB- cord-010119-t1x9gknd 11182 42 . . . cord-010119-t1x9gknd 11183 1 Conclusion conclusion NN cord-010119-t1x9gknd 11183 2 : : : cord-010119-t1x9gknd 11184 1 This this DT cord-010119-t1x9gknd 11184 2 study study NN cord-010119-t1x9gknd 11184 3 verified verify VBD cord-010119-t1x9gknd 11184 4 the the DT cord-010119-t1x9gknd 11184 5 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11184 6 provided provide VBN cord-010119-t1x9gknd 11184 7 significant significant JJ cord-010119-t1x9gknd 11184 8 efficiencies efficiency NNS cord-010119-t1x9gknd 11184 9 and and CC cord-010119-t1x9gknd 11184 10 cost cost NN cord-010119-t1x9gknd 11184 11 avoidance avoidance NN cord-010119-t1x9gknd 11184 12 over over IN cord-010119-t1x9gknd 11184 13 the the DT cord-010119-t1x9gknd 11184 14 Ortho Ortho NNP cord-010119-t1x9gknd 11184 15 ProVue ProVue NNP cord-010119-t1x9gknd 11184 16 for for IN cord-010119-t1x9gknd 11184 17 a a DT cord-010119-t1x9gknd 11184 18 large large JJ cord-010119-t1x9gknd 11184 19 volume volume NN cord-010119-t1x9gknd 11184 20 Transfusion Transfusion NNP cord-010119-t1x9gknd 11184 21 Service Service NNP cord-010119-t1x9gknd 11184 22 . . . cord-010119-t1x9gknd 11185 1 Workflow workflow NN cord-010119-t1x9gknd 11185 2 Comparison comparison NN cord-010119-t1x9gknd 11185 3 of of IN cord-010119-t1x9gknd 11185 4 Two Two NNP cord-010119-t1x9gknd 11185 5 High High NNP cord-010119-t1x9gknd 11185 6 Volume Volume NNP cord-010119-t1x9gknd 11185 7 , , , cord-010119-t1x9gknd 11185 8 High High NNP cord-010119-t1x9gknd 11185 9 Throughput Throughput NNP cord-010119-t1x9gknd 11185 10 Analyzers analyzer NNS cord-010119-t1x9gknd 11185 11 Aaron Aaron NNP cord-010119-t1x9gknd 11185 12 Samson Samson NNP cord-010119-t1x9gknd 11185 13 * * NFP cord-010119-t1x9gknd 11185 14 1 1 CD cord-010119-t1x9gknd 11185 15 , , , cord-010119-t1x9gknd 11185 16 Kimberly Kimberly NNP cord-010119-t1x9gknd 11185 17 Monnin Monnin NNP cord-010119-t1x9gknd 11185 18 1 1 CD cord-010119-t1x9gknd 11185 19 , , , cord-010119-t1x9gknd 11185 20 Barbara Barbara NNP cord-010119-t1x9gknd 11185 21 J J NNP cord-010119-t1x9gknd 11185 22 Bachman Bachman NNP cord-010119-t1x9gknd 11185 23 2 2 CD cord-010119-t1x9gknd 11185 24 , , , cord-010119-t1x9gknd 11185 25 Kyla Kyla NNP cord-010119-t1x9gknd 11185 26 Warren Warren NNP cord-010119-t1x9gknd 11185 27 2 2 CD cord-010119-t1x9gknd 11185 28 , , , cord-010119-t1x9gknd 11185 29 Susan Susan NNP cord-010119-t1x9gknd 11185 30 Olson Olson NNP cord-010119-t1x9gknd 11185 31 2 2 CD cord-010119-t1x9gknd 11185 32 and and CC cord-010119-t1x9gknd 11185 33 Candace Candace NNP cord-010119-t1x9gknd 11185 34 Williams Williams NNP cord-010119-t1x9gknd 11185 35 2 2 CD cord-010119-t1x9gknd 11185 36 . . . cord-010119-t1x9gknd 11186 1 1 1 LS cord-010119-t1x9gknd 11186 2 Clinical Clinical NNP cord-010119-t1x9gknd 11186 3 Pathology Pathology NNP cord-010119-t1x9gknd 11186 4 Labs Labs NNP cord-010119-t1x9gknd 11186 5 , , , cord-010119-t1x9gknd 11186 6 2 2 CD cord-010119-t1x9gknd 11186 7 Bio Bio NNP cord-010119-t1x9gknd 11186 8 - - HYPH cord-010119-t1x9gknd 11186 9 Rad Rad NNP cord-010119-t1x9gknd 11186 10 Laboratories Laboratories NNP cord-010119-t1x9gknd 11186 11 Background Background NNP cord-010119-t1x9gknd 11186 12 / / SYM cord-010119-t1x9gknd 11186 13 Case Case NNP cord-010119-t1x9gknd 11186 14 Studies Studies NNPS cord-010119-t1x9gknd 11186 15 : : : cord-010119-t1x9gknd 11186 16 Few few JJ cord-010119-t1x9gknd 11186 17 workflow workflow NN cord-010119-t1x9gknd 11186 18 studies study NNS cord-010119-t1x9gknd 11186 19 have have VBP cord-010119-t1x9gknd 11186 20 been be VBN cord-010119-t1x9gknd 11186 21 performed perform VBN cord-010119-t1x9gknd 11186 22 on on IN cord-010119-t1x9gknd 11186 23 high high JJ cord-010119-t1x9gknd 11186 24 volume volume NN cord-010119-t1x9gknd 11186 25 , , , cord-010119-t1x9gknd 11186 26 high high JJ cord-010119-t1x9gknd 11186 27 throughput throughput NN cord-010119-t1x9gknd 11186 28 blood blood NN cord-010119-t1x9gknd 11186 29 bank bank NN cord-010119-t1x9gknd 11186 30 analyzers analyzer NNS cord-010119-t1x9gknd 11186 31 in in IN cord-010119-t1x9gknd 11186 32 large large JJ cord-010119-t1x9gknd 11186 33 volume volume NN cord-010119-t1x9gknd 11186 34 testing testing NN cord-010119-t1x9gknd 11186 35 facilities facility NNS cord-010119-t1x9gknd 11186 36 . . . cord-010119-t1x9gknd 11187 1 The the DT cord-010119-t1x9gknd 11187 2 purpose purpose NN cord-010119-t1x9gknd 11187 3 of of IN cord-010119-t1x9gknd 11187 4 this this DT cord-010119-t1x9gknd 11187 5 study study NN cord-010119-t1x9gknd 11187 6 was be VBD cord-010119-t1x9gknd 11187 7 to to TO cord-010119-t1x9gknd 11187 8 evaluate evaluate VB cord-010119-t1x9gknd 11187 9 the the DT cord-010119-t1x9gknd 11187 10 Galileo Galileo NNP cord-010119-t1x9gknd 11187 11 V v NN cord-010119-t1x9gknd 11187 12 R r NN cord-010119-t1x9gknd 11187 13 Neo Neo NNP cord-010119-t1x9gknd 11187 14 ( ( -LRB- cord-010119-t1x9gknd 11187 15 Immucor Immucor NNP cord-010119-t1x9gknd 11187 16 ) ) -RRB- cord-010119-t1x9gknd 11187 17 against against IN cord-010119-t1x9gknd 11187 18 the the DT cord-010119-t1x9gknd 11187 19 IH-1000 IH-1000 NNP cord-010119-t1x9gknd 11187 20 TM TM NNP cord-010119-t1x9gknd 11187 21 ( ( -LRB- cord-010119-t1x9gknd 11187 22 Bio Bio NNP cord-010119-t1x9gknd 11187 23 - - HYPH cord-010119-t1x9gknd 11187 24 Rad Rad NNP cord-010119-t1x9gknd 11187 25 Laboratories Laboratories NNP cord-010119-t1x9gknd 11187 26 , , , cord-010119-t1x9gknd 11187 27 Inc. Inc. NNP cord-010119-t1x9gknd 11187 28 ) ) -RRB- cord-010119-t1x9gknd 11187 29 using use VBG cord-010119-t1x9gknd 11187 30 LEAN lean JJ cord-010119-t1x9gknd 11187 31 process process NN cord-010119-t1x9gknd 11187 32 flow flow NN cord-010119-t1x9gknd 11187 33 . . . cord-010119-t1x9gknd 11188 1 Study Study NNP cord-010119-t1x9gknd 11188 2 Design Design NNP cord-010119-t1x9gknd 11188 3 / / SYM cord-010119-t1x9gknd 11188 4 Method method NN cord-010119-t1x9gknd 11188 5 : : : cord-010119-t1x9gknd 11189 1 A a DT cord-010119-t1x9gknd 11189 2 total total NN cord-010119-t1x9gknd 11189 3 of of IN cord-010119-t1x9gknd 11189 4 12 12 CD cord-010119-t1x9gknd 11189 5 separate separate JJ cord-010119-t1x9gknd 11189 6 test test NN cord-010119-t1x9gknd 11189 7 runs run NNS cord-010119-t1x9gknd 11189 8 of of IN cord-010119-t1x9gknd 11189 9 72 72 CD cord-010119-t1x9gknd 11189 10 or or CC cord-010119-t1x9gknd 11189 11 144 144 CD cord-010119-t1x9gknd 11189 12 samples sample NNS cord-010119-t1x9gknd 11189 13 per per IN cord-010119-t1x9gknd 11189 14 run run NN cord-010119-t1x9gknd 11189 15 were be VBD cord-010119-t1x9gknd 11189 16 observed observe VBN cord-010119-t1x9gknd 11189 17 over over IN cord-010119-t1x9gknd 11189 18 a a DT cord-010119-t1x9gknd 11189 19 three three CD cord-010119-t1x9gknd 11189 20 day day NN cord-010119-t1x9gknd 11189 21 period period NN cord-010119-t1x9gknd 11189 22 on on IN cord-010119-t1x9gknd 11189 23 the the DT cord-010119-t1x9gknd 11189 24 Galileo Galileo NNP cord-010119-t1x9gknd 11189 25 Neo Neo NNP cord-010119-t1x9gknd 11189 26 at at IN cord-010119-t1x9gknd 11189 27 a a DT cord-010119-t1x9gknd 11189 28 reference reference NN cord-010119-t1x9gknd 11189 29 laboratory laboratory NN cord-010119-t1x9gknd 11189 30 annually annually RB cord-010119-t1x9gknd 11189 31 performing perform VBG cord-010119-t1x9gknd 11189 32 approximately approximately RB cord-010119-t1x9gknd 11189 33 211,500 211,500 CD cord-010119-t1x9gknd 11189 34 Type type NN cord-010119-t1x9gknd 11189 35 & & CC cord-010119-t1x9gknd 11189 36 Screens Screens NNPS cord-010119-t1x9gknd 11189 37 ( ( -LRB- cord-010119-t1x9gknd 11189 38 T&S T&S NNP cord-010119-t1x9gknd 11189 39 ) ) -RRB- cord-010119-t1x9gknd 11189 40 . . . cord-010119-t1x9gknd 11190 1 The the DT cord-010119-t1x9gknd 11190 2 workflow workflow NN cord-010119-t1x9gknd 11190 3 patterns pattern NNS cord-010119-t1x9gknd 11190 4 observed observe VBN cord-010119-t1x9gknd 11190 5 were be VBD cord-010119-t1x9gknd 11190 6 then then RB cord-010119-t1x9gknd 11190 7 repeated repeat VBN cord-010119-t1x9gknd 11190 8 on on IN cord-010119-t1x9gknd 11190 9 the the DT cord-010119-t1x9gknd 11190 10 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11190 11 and and CC cord-010119-t1x9gknd 11190 12 compared compare VBN cord-010119-t1x9gknd 11190 13 . . . cord-010119-t1x9gknd 11191 1 Each each DT cord-010119-t1x9gknd 11191 2 process process NN cord-010119-t1x9gknd 11191 3 was be VBD cord-010119-t1x9gknd 11191 4 mapped map VBN cord-010119-t1x9gknd 11191 5 in in IN cord-010119-t1x9gknd 11191 6 detail detail NN cord-010119-t1x9gknd 11191 7 by by IN cord-010119-t1x9gknd 11191 8 direct direct JJ cord-010119-t1x9gknd 11191 9 observation observation NN cord-010119-t1x9gknd 11191 10 using use VBG cord-010119-t1x9gknd 11191 11 Process Process NNP cord-010119-t1x9gknd 11191 12 Modellar Modellar NNP cord-010119-t1x9gknd 11191 13 APP APP NNP cord-010119-t1x9gknd 11191 14 ( ( -LRB- cord-010119-t1x9gknd 11191 15 iPAD iPAD NNP cord-010119-t1x9gknd 11191 16 ) ) -RRB- cord-010119-t1x9gknd 11191 17 . . . cord-010119-t1x9gknd 11192 1 The the DT cord-010119-t1x9gknd 11192 2 evaluation evaluation NN cord-010119-t1x9gknd 11192 3 started start VBD cord-010119-t1x9gknd 11192 4 at at IN cord-010119-t1x9gknd 11192 5 sample sample NN cord-010119-t1x9gknd 11192 6 centrifugation centrifugation NN cord-010119-t1x9gknd 11192 7 completion completion NN cord-010119-t1x9gknd 11192 8 and and CC cord-010119-t1x9gknd 11192 9 drop drop NN cord-010119-t1x9gknd 11192 10 - - HYPH cord-010119-t1x9gknd 11192 11 off off NN cord-010119-t1x9gknd 11192 12 in in IN cord-010119-t1x9gknd 11192 13 testing testing NN cord-010119-t1x9gknd 11192 14 area area NN cord-010119-t1x9gknd 11192 15 and and CC cord-010119-t1x9gknd 11192 16 ended end VBD cord-010119-t1x9gknd 11192 17 with with IN cord-010119-t1x9gknd 11192 18 results result NNS cord-010119-t1x9gknd 11192 19 sent send VBN cord-010119-t1x9gknd 11192 20 from from IN cord-010119-t1x9gknd 11192 21 analyzer analyzer NN cord-010119-t1x9gknd 11192 22 to to IN cord-010119-t1x9gknd 11192 23 LIS LIS NNP cord-010119-t1x9gknd 11192 24 ( ( -LRB- cord-010119-t1x9gknd 11192 25 Lab Lab NNP cord-010119-t1x9gknd 11192 26 Information Information NNP cord-010119-t1x9gknd 11192 27 System System NNP cord-010119-t1x9gknd 11192 28 ) ) -RRB- cord-010119-t1x9gknd 11192 29 . . . cord-010119-t1x9gknd 11193 1 Each each DT cord-010119-t1x9gknd 11193 2 was be VBD cord-010119-t1x9gknd 11193 3 evaluated evaluate VBN cord-010119-t1x9gknd 11193 4 for for IN cord-010119-t1x9gknd 11193 5 quality quality NN cord-010119-t1x9gknd 11193 6 ( ( -LRB- cord-010119-t1x9gknd 11193 7 process process NN cord-010119-t1x9gknd 11193 8 steps step NNS cord-010119-t1x9gknd 11193 9 , , , cord-010119-t1x9gknd 11193 10 biohazardous biohazardous JJ cord-010119-t1x9gknd 11193 11 exposure exposure NN cord-010119-t1x9gknd 11193 12 ) ) -RRB- cord-010119-t1x9gknd 11193 13 , , , cord-010119-t1x9gknd 11193 14 speed speed NN cord-010119-t1x9gknd 11193 15 ( ( -LRB- cord-010119-t1x9gknd 11193 16 operator operator NN cord-010119-t1x9gknd 11193 17 / / SYM cord-010119-t1x9gknd 11193 18 analyzer analyzer NN cord-010119-t1x9gknd 11193 19 time time NN cord-010119-t1x9gknd 11193 20 ) ) -RRB- cord-010119-t1x9gknd 11193 21 and and CC cord-010119-t1x9gknd 11193 22 cost cost NN cord-010119-t1x9gknd 11193 23 ( ( -LRB- cord-010119-t1x9gknd 11193 24 testing testing NN cord-010119-t1x9gknd 11193 25 / / SYM cord-010119-t1x9gknd 11193 26 maintenance maintenance NN cord-010119-t1x9gknd 11193 27 personnel personnel NNS cord-010119-t1x9gknd 11193 28 hours hour NNS cord-010119-t1x9gknd 11193 29 recaptured recapture VBN cord-010119-t1x9gknd 11193 30 ) ) -RRB- cord-010119-t1x9gknd 11193 31 . . . cord-010119-t1x9gknd 11194 1 Time Time NNP cord-010119-t1x9gknd 11194 2 studies study NNS cord-010119-t1x9gknd 11194 3 were be VBD cord-010119-t1x9gknd 11194 4 analyzed analyze VBN cord-010119-t1x9gknd 11194 5 using use VBG cord-010119-t1x9gknd 11194 6 Minitab Minitab NNP cord-010119-t1x9gknd 11194 7 v17 v17 NNP cord-010119-t1x9gknd 11194 8 , , , cord-010119-t1x9gknd 11194 9 and and CC cord-010119-t1x9gknd 11194 10 statistical statistical JJ cord-010119-t1x9gknd 11194 11 significance significance NN cord-010119-t1x9gknd 11194 12 was be VBD cord-010119-t1x9gknd 11194 13 assessed assess VBN cord-010119-t1x9gknd 11194 14 using use VBG cord-010119-t1x9gknd 11194 15 the the DT cord-010119-t1x9gknd 11194 16 paired paired JJ cord-010119-t1x9gknd 11194 17 t t NN cord-010119-t1x9gknd 11194 18 - - HYPH cord-010119-t1x9gknd 11194 19 test test NN cord-010119-t1x9gknd 11194 20 , , , cord-010119-t1x9gknd 11194 21 with with IN cord-010119-t1x9gknd 11194 22 p p NN cord-010119-t1x9gknd 11194 23 values value NNS cord-010119-t1x9gknd 11194 24 of of IN cord-010119-t1x9gknd 11194 25 < < NNP cord-010119-t1x9gknd 11194 26 0.05 0.05 CD cord-010119-t1x9gknd 11194 27 considered consider VBN cord-010119-t1x9gknd 11194 28 significant significant JJ cord-010119-t1x9gknd 11194 29 . . . cord-010119-t1x9gknd 11195 1 Results result NNS cord-010119-t1x9gknd 11196 1 /Finding /finde VBG cord-010119-t1x9gknd 11196 2 : : : cord-010119-t1x9gknd 11197 1 Detailed detailed JJ cord-010119-t1x9gknd 11197 2 process process NN cord-010119-t1x9gknd 11197 3 steps step NNS cord-010119-t1x9gknd 11197 4 , , , cord-010119-t1x9gknd 11197 5 biohazardous biohazardous JJ cord-010119-t1x9gknd 11197 6 exposures exposure NNS cord-010119-t1x9gknd 11197 7 , , , cord-010119-t1x9gknd 11197 8 and and CC cord-010119-t1x9gknd 11197 9 published publish VBD cord-010119-t1x9gknd 11197 10 analyzer analyzer NN cord-010119-t1x9gknd 11197 11 maintenance maintenance NN cord-010119-t1x9gknd 11197 12 tasks task NNS cord-010119-t1x9gknd 11197 13 were be VBD cord-010119-t1x9gknd 11197 14 evaluated evaluate VBN cord-010119-t1x9gknd 11197 15 / / SYM cord-010119-t1x9gknd 11197 16 compared compare VBN cord-010119-t1x9gknd 11197 17 ( ( -LRB- cord-010119-t1x9gknd 11197 18 Table table NN cord-010119-t1x9gknd 11197 19 , , , cord-010119-t1x9gknd 11197 20 _SP cord-010119-t1x9gknd 11197 21 Part Part NNP cord-010119-t1x9gknd 11197 22 A A NNP cord-010119-t1x9gknd 11197 23 ) ) -RRB- cord-010119-t1x9gknd 11197 24 . . . cord-010119-t1x9gknd 11198 1 Time Time NNP cord-010119-t1x9gknd 11198 2 studies study NNS cord-010119-t1x9gknd 11198 3 focused focus VBD cord-010119-t1x9gknd 11198 4 on on IN cord-010119-t1x9gknd 11198 5 operator operator NN cord-010119-t1x9gknd 11198 6 time time NN cord-010119-t1x9gknd 11198 7 , , , cord-010119-t1x9gknd 11198 8 analyzer analyzer NN cord-010119-t1x9gknd 11198 9 time time NN cord-010119-t1x9gknd 11198 10 , , , cord-010119-t1x9gknd 11198 11 and and CC cord-010119-t1x9gknd 11198 12 maintenance maintenance NN cord-010119-t1x9gknd 11198 13 time time NN cord-010119-t1x9gknd 11198 14 ( ( -LRB- cord-010119-t1x9gknd 11198 15 Table table NN cord-010119-t1x9gknd 11198 16 , , , cord-010119-t1x9gknd 11198 17 Part Part NNP cord-010119-t1x9gknd 11198 18 B B NNP cord-010119-t1x9gknd 11198 19 ) ) -RRB- cord-010119-t1x9gknd 11198 20 . . . cord-010119-t1x9gknd 11199 1 Regardless regardless RB cord-010119-t1x9gknd 11199 2 of of IN cord-010119-t1x9gknd 11199 3 quality quality NN cord-010119-t1x9gknd 11199 4 or or CC cord-010119-t1x9gknd 11199 5 speed speed NN cord-010119-t1x9gknd 11199 6 metrics metric NNS cord-010119-t1x9gknd 11199 7 evaluated evaluate VBN cord-010119-t1x9gknd 11199 8 , , , cord-010119-t1x9gknd 11199 9 the the DT cord-010119-t1x9gknd 11199 10 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11199 11 demonstrated demonstrate VBD cord-010119-t1x9gknd 11199 12 significant significant JJ cord-010119-t1x9gknd 11199 13 reduction reduction NN cord-010119-t1x9gknd 11199 14 ( ( -LRB- cord-010119-t1x9gknd 11199 15 improvement improvement NN cord-010119-t1x9gknd 11199 16 ) ) -RRB- cord-010119-t1x9gknd 11199 17 in in IN cord-010119-t1x9gknd 11199 18 process process NN cord-010119-t1x9gknd 11199 19 steps step NNS cord-010119-t1x9gknd 11199 20 and and CC cord-010119-t1x9gknd 11199 21 associated associate VBD cord-010119-t1x9gknd 11199 22 times time NNS cord-010119-t1x9gknd 11199 23 when when WRB cord-010119-t1x9gknd 11199 24 compared compare VBN cord-010119-t1x9gknd 11199 25 against against IN cord-010119-t1x9gknd 11199 26 the the DT cord-010119-t1x9gknd 11199 27 Galileo Galileo NNP cord-010119-t1x9gknd 11199 28 Neo Neo NNP cord-010119-t1x9gknd 11199 29 ( ( -LRB- cord-010119-t1x9gknd 11199 30 p p NN cord-010119-t1x9gknd 11199 31 < < XX cord-010119-t1x9gknd 11199 32 0.001 0.001 CD cord-010119-t1x9gknd 11199 33 ) ) -RRB- cord-010119-t1x9gknd 11199 34 . . . cord-010119-t1x9gknd 11200 1 Evaluating evaluate VBG cord-010119-t1x9gknd 11200 2 the the DT cord-010119-t1x9gknd 11200 3 total total JJ cord-010119-t1x9gknd 11200 4 number number NN cord-010119-t1x9gknd 11200 5 of of IN cord-010119-t1x9gknd 11200 6 maintenance maintenance NN cord-010119-t1x9gknd 11200 7 tasks task NNS cord-010119-t1x9gknd 11200 8 required require VBN cord-010119-t1x9gknd 11200 9 annually annually RB cord-010119-t1x9gknd 11200 10 , , , cord-010119-t1x9gknd 11200 11 as as RB cord-010119-t1x9gknd 11200 12 well well RB cord-010119-t1x9gknd 11200 13 as as IN cord-010119-t1x9gknd 11200 14 the the DT cord-010119-t1x9gknd 11200 15 times time NNS cord-010119-t1x9gknd 11200 16 associated associate VBN cord-010119-t1x9gknd 11200 17 with with IN cord-010119-t1x9gknd 11200 18 maintenance maintenance NN cord-010119-t1x9gknd 11200 19 performance performance NN cord-010119-t1x9gknd 11200 20 and and CC cord-010119-t1x9gknd 11200 21 downtime downtime NN cord-010119-t1x9gknd 11200 22 , , , cord-010119-t1x9gknd 11200 23 was be VBD cord-010119-t1x9gknd 11200 24 a a DT cord-010119-t1x9gknd 11200 25 significantly significantly RB cord-010119-t1x9gknd 11200 26 reduced reduce VBN cord-010119-t1x9gknd 11200 27 on on IN cord-010119-t1x9gknd 11200 28 the the DT cord-010119-t1x9gknd 11200 29 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11201 1 ( ( -LRB- cord-010119-t1x9gknd 11201 2 difference difference NN cord-010119-t1x9gknd 11201 3 of of IN cord-010119-t1x9gknd 11201 4 120 120 CD cord-010119-t1x9gknd 11201 5 hours hour NNS cord-010119-t1x9gknd 11201 6 / / SYM cord-010119-t1x9gknd 11201 7 year year NN cord-010119-t1x9gknd 11201 8 ) ) -RRB- cord-010119-t1x9gknd 11201 9 . . . cord-010119-t1x9gknd 11202 1 Conclusion conclusion NN cord-010119-t1x9gknd 11202 2 : : : cord-010119-t1x9gknd 11203 1 This this DT cord-010119-t1x9gknd 11203 2 study study NN cord-010119-t1x9gknd 11203 3 verified verify VBD cord-010119-t1x9gknd 11203 4 the the DT cord-010119-t1x9gknd 11203 5 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11203 6 provided provide VBN cord-010119-t1x9gknd 11203 7 significant significant JJ cord-010119-t1x9gknd 11203 8 efficiencies efficiency NNS cord-010119-t1x9gknd 11203 9 and and CC cord-010119-t1x9gknd 11203 10 cost cost NN cord-010119-t1x9gknd 11203 11 avoidance avoidance NN cord-010119-t1x9gknd 11203 12 over over IN cord-010119-t1x9gknd 11203 13 the the DT cord-010119-t1x9gknd 11203 14 Galileo Galileo NNP cord-010119-t1x9gknd 11203 15 Neo Neo NNP cord-010119-t1x9gknd 11203 16 for for IN cord-010119-t1x9gknd 11203 17 high high JJ cord-010119-t1x9gknd 11203 18 volume volume NN cord-010119-t1x9gknd 11203 19 / / SYM cord-010119-t1x9gknd 11203 20 high high JJ cord-010119-t1x9gknd 11203 21 throughput throughput NN cord-010119-t1x9gknd 11203 22 testing test VBG cord-010119-t1x9gknd 11203 23 facilities facility NNS cord-010119-t1x9gknd 11203 24 . . . cord-010119-t1x9gknd 11204 1 Workflow Workflow NNP cord-010119-t1x9gknd 11204 2 Impact Impact NNP cord-010119-t1x9gknd 11204 3 of of IN cord-010119-t1x9gknd 11204 4 Automated Automated NNP cord-010119-t1x9gknd 11204 5 Result Result NNP cord-010119-t1x9gknd 11204 6 Verification Verification NNP cord-010119-t1x9gknd 11204 7 for for IN cord-010119-t1x9gknd 11204 8 Patient Patient NNP cord-010119-t1x9gknd 11204 9 and and CC cord-010119-t1x9gknd 11204 10 Donor Donor NNP cord-010119-t1x9gknd 11204 11 Blood Blood NNP cord-010119-t1x9gknd 11204 12 Typing type VBG cord-010119-t1x9gknd 11204 13 Barbara Barbara NNP cord-010119-t1x9gknd 11204 14 J J NNP cord-010119-t1x9gknd 11204 15 Bachman Bachman NNP cord-010119-t1x9gknd 11205 1 * * NFP cord-010119-t1x9gknd 11205 2 1 1 CD cord-010119-t1x9gknd 11205 3 , , , cord-010119-t1x9gknd 11205 4 Candace Candace NNP cord-010119-t1x9gknd 11205 5 Williams Williams NNP cord-010119-t1x9gknd 11205 6 1 1 CD cord-010119-t1x9gknd 11205 7 , , , cord-010119-t1x9gknd 11205 8 Carmen Carmen NNP cord-010119-t1x9gknd 11205 9 Meyer Meyer NNP cord-010119-t1x9gknd 11205 10 2 2 CD cord-010119-t1x9gknd 11205 11 , , , cord-010119-t1x9gknd 11205 12 Paul Paul NNP cord-010119-t1x9gknd 11205 13 Lamonby Lamonby NNP cord-010119-t1x9gknd 11205 14 1 1 CD cord-010119-t1x9gknd 11205 15 , , , cord-010119-t1x9gknd 11205 16 Anne Anne NNP cord-010119-t1x9gknd 11205 17 Cleverley Cleverley NNP cord-010119-t1x9gknd 11205 18 1 1 CD cord-010119-t1x9gknd 11205 19 and and CC cord-010119-t1x9gknd 11205 20 Silke Silke NNP cord-010119-t1x9gknd 11205 21 Milbradt Milbradt NNP cord-010119-t1x9gknd 11205 22 - - HYPH cord-010119-t1x9gknd 11205 23 Pohan Pohan NNP cord-010119-t1x9gknd 11205 24 1 1 CD cord-010119-t1x9gknd 11205 25 . . . cord-010119-t1x9gknd 11206 1 1 1 CD cord-010119-t1x9gknd 11206 2 Bio Bio NNP cord-010119-t1x9gknd 11206 3 - - HYPH cord-010119-t1x9gknd 11206 4 Rad Rad NNP cord-010119-t1x9gknd 11206 5 Laboratories Laboratories NNP cord-010119-t1x9gknd 11206 6 , , , cord-010119-t1x9gknd 11206 7 2 2 CD cord-010119-t1x9gknd 11206 8 Diamed Diamed NNP cord-010119-t1x9gknd 11206 9 Gmbh Gmbh NNP cord-010119-t1x9gknd 11206 10 Background Background NNP cord-010119-t1x9gknd 11206 11 / / SYM cord-010119-t1x9gknd 11206 12 Case Case NNP cord-010119-t1x9gknd 11206 13 Studies Studies NNPS cord-010119-t1x9gknd 11206 14 : : : cord-010119-t1x9gknd 11207 1 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 11207 2 facilities facility NNS cord-010119-t1x9gknd 11207 3 face face VBP cord-010119-t1x9gknd 11207 4 many many JJ cord-010119-t1x9gknd 11207 5 challenges challenge NNS cord-010119-t1x9gknd 11207 6 including include VBG cord-010119-t1x9gknd 11207 7 standardization standardization NN cord-010119-t1x9gknd 11207 8 , , , cord-010119-t1x9gknd 11207 9 process process NN cord-010119-t1x9gknd 11207 10 control control NN cord-010119-t1x9gknd 11207 11 , , , cord-010119-t1x9gknd 11207 12 productivity productivity NN cord-010119-t1x9gknd 11207 13 , , , cord-010119-t1x9gknd 11207 14 staffing staffing NN cord-010119-t1x9gknd 11207 15 and and CC cord-010119-t1x9gknd 11207 16 patient patient JJ cord-010119-t1x9gknd 11207 17 safety safety NN cord-010119-t1x9gknd 11207 18 . . . cord-010119-t1x9gknd 11208 1 To to TO cord-010119-t1x9gknd 11208 2 alleviate alleviate VB cord-010119-t1x9gknd 11208 3 these these DT cord-010119-t1x9gknd 11208 4 challenges challenge NNS cord-010119-t1x9gknd 11208 5 , , , cord-010119-t1x9gknd 11208 6 the the DT cord-010119-t1x9gknd 11208 7 IH-1000 IH-1000 NNP cord-010119-t1x9gknd 11208 8 TM TM NNP cord-010119-t1x9gknd 11208 9 instrument instrument NN cord-010119-t1x9gknd 11208 10 and and CC cord-010119-t1x9gknd 11208 11 complementary complementary JJ cord-010119-t1x9gknd 11208 12 IH IH NNP cord-010119-t1x9gknd 11208 13 - - HYPH cord-010119-t1x9gknd 11208 14 Com Com NNP cord-010119-t1x9gknd 11208 15 TM TM NNP cord-010119-t1x9gknd 11208 16 Data Data NNP cord-010119-t1x9gknd 11208 17 Management Management NNP cord-010119-t1x9gknd 11208 18 System System NNP cord-010119-t1x9gknd 11208 19 ( ( -LRB- cord-010119-t1x9gknd 11208 20 DMS DMS NNP cord-010119-t1x9gknd 11208 21 ) ) -RRB- cord-010119-t1x9gknd 11208 22 were be VBD cord-010119-t1x9gknd 11208 23 designed design VBN cord-010119-t1x9gknd 11208 24 to to TO cord-010119-t1x9gknd 11208 25 provide provide VB cord-010119-t1x9gknd 11208 26 lean lean JJ cord-010119-t1x9gknd 11208 27 automation automation NN cord-010119-t1x9gknd 11208 28 to to TO cord-010119-t1x9gknd 11208 29 enhance enhance VB cord-010119-t1x9gknd 11208 30 blood blood NN cord-010119-t1x9gknd 11208 31 testing testing NN cord-010119-t1x9gknd 11208 32 facility facility NN cord-010119-t1x9gknd 11208 33 workflow workflow NN cord-010119-t1x9gknd 11208 34 . . . cord-010119-t1x9gknd 11209 1 The the DT cord-010119-t1x9gknd 11209 2 purpose purpose NN cord-010119-t1x9gknd 11209 3 of of IN cord-010119-t1x9gknd 11209 4 this this DT cord-010119-t1x9gknd 11209 5 study study NN cord-010119-t1x9gknd 11209 6 was be VBD cord-010119-t1x9gknd 11209 7 to to TO cord-010119-t1x9gknd 11209 8 focus focus VB cord-010119-t1x9gknd 11209 9 on on IN cord-010119-t1x9gknd 11209 10 the the DT cord-010119-t1x9gknd 11209 11 lean lean JJ cord-010119-t1x9gknd 11209 12 functionality functionality NN cord-010119-t1x9gknd 11209 13 of of IN cord-010119-t1x9gknd 11209 14 automated automated JJ cord-010119-t1x9gknd 11209 15 result result NN cord-010119-t1x9gknd 11209 16 verification verification NN cord-010119-t1x9gknd 11209 17 on on IN cord-010119-t1x9gknd 11209 18 the the DT cord-010119-t1x9gknd 11209 19 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11209 20 and and CC cord-010119-t1x9gknd 11209 21 IH IH NNP cord-010119-t1x9gknd 11209 22 - - HYPH cord-010119-t1x9gknd 11209 23 Com Com NNP cord-010119-t1x9gknd 11209 24 DMS dms NN cord-010119-t1x9gknd 11209 25 and and CC cord-010119-t1x9gknd 11209 26 determine determine VB cord-010119-t1x9gknd 11209 27 its -PRON- PRP$ cord-010119-t1x9gknd 11209 28 impact impact NN cord-010119-t1x9gknd 11209 29 on on IN cord-010119-t1x9gknd 11209 30 workflow workflow NN cord-010119-t1x9gknd 11209 31 . . . cord-010119-t1x9gknd 11210 1 Study Study NNP cord-010119-t1x9gknd 11210 2 Design Design NNP cord-010119-t1x9gknd 11210 3 / / SYM cord-010119-t1x9gknd 11210 4 Methods method NNS cord-010119-t1x9gknd 11210 5 : : : cord-010119-t1x9gknd 11211 1 Internal internal JJ cord-010119-t1x9gknd 11211 2 and and CC cord-010119-t1x9gknd 11211 3 external external JJ cord-010119-t1x9gknd 11211 4 studies study NNS cord-010119-t1x9gknd 11211 5 using use VBG cord-010119-t1x9gknd 11211 6 the the DT cord-010119-t1x9gknd 11211 7 IH-1000 ih-1000 NN cord-010119-t1x9gknd 11211 8 with with IN cord-010119-t1x9gknd 11211 9 the the DT cord-010119-t1x9gknd 11211 10 IH IH NNP cord-010119-t1x9gknd 11211 11 - - HYPH cord-010119-t1x9gknd 11211 12 Com Com NNP cord-010119-t1x9gknd 11211 13 DMS DMS NNP cord-010119-t1x9gknd 11211 14 were be VBD cord-010119-t1x9gknd 11211 15 performed perform VBN cord-010119-t1x9gknd 11211 16 with with IN cord-010119-t1x9gknd 11211 17 patient patient NN cord-010119-t1x9gknd 11211 18 and and CC cord-010119-t1x9gknd 11211 19 donor donor NN cord-010119-t1x9gknd 11211 20 samples sample NNS cord-010119-t1x9gknd 11211 21 . . . cord-010119-t1x9gknd 11212 1 Assays assay NNS cord-010119-t1x9gknd 11212 2 included include VBD cord-010119-t1x9gknd 11212 3 ABO ABO NNP cord-010119-t1x9gknd 11212 4 / / SYM cord-010119-t1x9gknd 11212 5 Rh Rh NNP cord-010119-t1x9gknd 11212 6 blood blood NN cord-010119-t1x9gknd 11212 7 grouping grouping NN cord-010119-t1x9gknd 11212 8 and and CC cord-010119-t1x9gknd 11212 9 antibody antibody NN cord-010119-t1x9gknd 11212 10 screening screening NN cord-010119-t1x9gknd 11212 11 ( ( -LRB- cord-010119-t1x9gknd 11212 12 ABS abs NN cord-010119-t1x9gknd 11212 13 ) ) -RRB- cord-010119-t1x9gknd 11212 14 as as IN cord-010119-t1x9gknd 11212 15 shown show VBN cord-010119-t1x9gknd 11212 16 in in IN cord-010119-t1x9gknd 11212 17 Table Table NNP cord-010119-t1x9gknd 11212 18 A A NNP cord-010119-t1x9gknd 11212 19 . . . cord-010119-t1x9gknd 11213 1 Workflow workflow NN cord-010119-t1x9gknd 11213 2 data datum NNS cord-010119-t1x9gknd 11213 3 was be VBD cord-010119-t1x9gknd 11213 4 analyzed analyze VBN cord-010119-t1x9gknd 11213 5 using use VBG cord-010119-t1x9gknd 11213 6 Process Process NNP cord-010119-t1x9gknd 11213 7 Modellar Modellar NNP cord-010119-t1x9gknd 11213 8 APP app NN cord-010119-t1x9gknd 11213 9 ( ( -LRB- cord-010119-t1x9gknd 11213 10 iPad iPad NNP cord-010119-t1x9gknd 11213 11 ) ) -RRB- cord-010119-t1x9gknd 11213 12 . . . cord-010119-t1x9gknd 11214 1 The the DT cord-010119-t1x9gknd 11214 2 evaluation evaluation NN cord-010119-t1x9gknd 11214 3 focused focus VBD cord-010119-t1x9gknd 11214 4 on on IN cord-010119-t1x9gknd 11214 5 post post JJ cord-010119-t1x9gknd 11214 6 - - JJ cord-010119-t1x9gknd 11214 7 analytical analytical JJ cord-010119-t1x9gknd 11214 8 steps step NNS cord-010119-t1x9gknd 11214 9 of of IN cord-010119-t1x9gknd 11214 10 result result NN cord-010119-t1x9gknd 11214 11 verification verification NN cord-010119-t1x9gknd 11214 12 , , , cord-010119-t1x9gknd 11214 13 evaluating evaluate VBG cord-010119-t1x9gknd 11214 14 with with IN cord-010119-t1x9gknd 11214 15 and and CC cord-010119-t1x9gknd 11214 16 without without IN cord-010119-t1x9gknd 11214 17 automated automated JJ cord-010119-t1x9gknd 11214 18 result result NN cord-010119-t1x9gknd 11214 19 verification verification NN cord-010119-t1x9gknd 11214 20 to to TO cord-010119-t1x9gknd 11214 21 determine determine VB cord-010119-t1x9gknd 11214 22 the the DT cord-010119-t1x9gknd 11214 23 impact impact NN cord-010119-t1x9gknd 11214 24 on on IN cord-010119-t1x9gknd 11214 25 quality quality NN cord-010119-t1x9gknd 11214 26 ( ( -LRB- cord-010119-t1x9gknd 11214 27 operator operator NN cord-010119-t1x9gknd 11214 28 touchpoints touchpoint NNS cord-010119-t1x9gknd 11214 29 , , , cord-010119-t1x9gknd 11214 30 visual visual JJ cord-010119-t1x9gknd 11214 31 result result NN cord-010119-t1x9gknd 11214 32 review review NN cord-010119-t1x9gknd 11214 33 occurrence occurrence NN cord-010119-t1x9gknd 11214 34 , , , cord-010119-t1x9gknd 11214 35 result result NN cord-010119-t1x9gknd 11214 36 accuracy accuracy NN cord-010119-t1x9gknd 11214 37 ) ) -RRB- cord-010119-t1x9gknd 11214 38 , , , cord-010119-t1x9gknd 11214 39 and and CC cord-010119-t1x9gknd 11214 40 speed speed NN cord-010119-t1x9gknd 11214 41 ( ( -LRB- cord-010119-t1x9gknd 11214 42 time time NN cord-010119-t1x9gknd 11214 43 from from IN cord-010119-t1x9gknd 11214 44 result result JJ cord-010119-t1x9gknd 11214 45 interpretation interpretation NN cord-010119-t1x9gknd 11214 46 to to IN cord-010119-t1x9gknd 11214 47 LIS LIS NNP cord-010119-t1x9gknd 11214 48 data datum NNS cord-010119-t1x9gknd 11214 49 transfer transfer NN cord-010119-t1x9gknd 11214 50 ) ) -RRB- cord-010119-t1x9gknd 11214 51 . . . cord-010119-t1x9gknd 11215 1 Operator operator NN cord-010119-t1x9gknd 11215 2 touchpoints touchpoint NNS cord-010119-t1x9gknd 11215 3 during during IN cord-010119-t1x9gknd 11215 4 the the DT cord-010119-t1x9gknd 11215 5 post post JJ cord-010119-t1x9gknd 11215 6 - - JJ cord-010119-t1x9gknd 11215 7 analytical analytical JJ cord-010119-t1x9gknd 11215 8 phase phase NN cord-010119-t1x9gknd 11215 9 are be VBP cord-010119-t1x9gknd 11215 10 only only RB cord-010119-t1x9gknd 11215 11 required require VBN cord-010119-t1x9gknd 11215 12 when when WRB cord-010119-t1x9gknd 11215 13 doing do VBG cord-010119-t1x9gknd 11215 14 visual visual JJ cord-010119-t1x9gknd 11215 15 result result NN cord-010119-t1x9gknd 11215 16 verification verification NN cord-010119-t1x9gknd 11215 17 and and CC cord-010119-t1x9gknd 11215 18 are be VBP cord-010119-t1x9gknd 11215 19 software software NN cord-010119-t1x9gknd 11215 20 defined define VBN cord-010119-t1x9gknd 11215 21 . . . cord-010119-t1x9gknd 11216 1 Speed speed NN cord-010119-t1x9gknd 11216 2 metrics metric NNS cord-010119-t1x9gknd 11216 3 were be VBD cord-010119-t1x9gknd 11216 4 analyzed analyze VBN cord-010119-t1x9gknd 11216 5 using use VBG cord-010119-t1x9gknd 11216 6 Minitab Minitab NNP cord-010119-t1x9gknd 11216 7 v17 v17 NNP cord-010119-t1x9gknd 11216 8 . . . cord-010119-t1x9gknd 11217 1 Statistical statistical JJ cord-010119-t1x9gknd 11217 2 significance significance NN cord-010119-t1x9gknd 11217 3 was be VBD cord-010119-t1x9gknd 11217 4 assessed assess VBN cord-010119-t1x9gknd 11217 5 using use VBG cord-010119-t1x9gknd 11217 6 the the DT cord-010119-t1x9gknd 11217 7 paired paired JJ cord-010119-t1x9gknd 11217 8 t t NN cord-010119-t1x9gknd 11217 9 - - HYPH cord-010119-t1x9gknd 11217 10 test test NN cord-010119-t1x9gknd 11217 11 , , , cord-010119-t1x9gknd 11217 12 with with IN cord-010119-t1x9gknd 11217 13 p p NN cord-010119-t1x9gknd 11217 14 values value NNS cord-010119-t1x9gknd 11217 15 of of IN cord-010119-t1x9gknd 11217 16 < < NNP cord-010119-t1x9gknd 11217 17 0.05 0.05 CD cord-010119-t1x9gknd 11217 18 considered consider VBN cord-010119-t1x9gknd 11217 19 significant significant JJ cord-010119-t1x9gknd 11217 20 . . . cord-010119-t1x9gknd 11218 1 Results result NNS cord-010119-t1x9gknd 11218 2 / / SYM cord-010119-t1x9gknd 11218 3 Findings finding NNS cord-010119-t1x9gknd 11218 4 : : : cord-010119-t1x9gknd 11218 5 Using use VBG cord-010119-t1x9gknd 11218 6 automated automated JJ cord-010119-t1x9gknd 11218 7 result result NN cord-010119-t1x9gknd 11218 8 verification verification NN cord-010119-t1x9gknd 11218 9 , , , cord-010119-t1x9gknd 11218 10 only only RB cord-010119-t1x9gknd 11218 11 0.93 0.93 CD cord-010119-t1x9gknd 11218 12 % % NN cord-010119-t1x9gknd 11218 13 out out IN cord-010119-t1x9gknd 11218 14 of of IN cord-010119-t1x9gknd 11218 15 6,339 6,339 CD cord-010119-t1x9gknd 11218 16 samples sample NNS cord-010119-t1x9gknd 11218 17 evaluated evaluate VBN cord-010119-t1x9gknd 11218 18 for for IN cord-010119-t1x9gknd 11218 19 ABO ABO NNP cord-010119-t1x9gknd 11218 20 / / SYM cord-010119-t1x9gknd 11218 21 Rh Rh NNP cord-010119-t1x9gknd 11218 22 testing testing NN cord-010119-t1x9gknd 11218 23 would would MD cord-010119-t1x9gknd 11218 24 require require VB cord-010119-t1x9gknd 11218 25 visual visual JJ cord-010119-t1x9gknd 11218 26 verification verification NN cord-010119-t1x9gknd 11218 27 , , , cord-010119-t1x9gknd 11218 28 resulting result VBG cord-010119-t1x9gknd 11218 29 in in IN cord-010119-t1x9gknd 11218 30 a a DT cord-010119-t1x9gknd 11218 31 98 98 CD cord-010119-t1x9gknd 11218 32 % % NN cord-010119-t1x9gknd 11218 33 reduction reduction NN cord-010119-t1x9gknd 11218 34 in in IN cord-010119-t1x9gknd 11218 35 operator operator NN cord-010119-t1x9gknd 11218 36 touchpoints touchpoint NNS cord-010119-t1x9gknd 11218 37 ( ( -LRB- cord-010119-t1x9gknd 11218 38 p p NN cord-010119-t1x9gknd 11218 39 < < XX cord-010119-t1x9gknd 11218 40 0.001 0.001 CD cord-010119-t1x9gknd 11218 41 ) ) -RRB- cord-010119-t1x9gknd 11218 42 and and CC cord-010119-t1x9gknd 11218 43 a a DT cord-010119-t1x9gknd 11218 44 labor labor NN cord-010119-t1x9gknd 11218 45 saving saving NN cord-010119-t1x9gknd 11218 46 of of IN cord-010119-t1x9gknd 11218 47 444 444 CD cord-010119-t1x9gknd 11218 48 minutes minute NNS cord-010119-t1x9gknd 11218 49 ( ( -LRB- cord-010119-t1x9gknd 11218 50 7:01 7:01 CD cord-010119-t1x9gknd 11218 51 hh hh NN cord-010119-t1x9gknd 11218 52 : : : cord-010119-t1x9gknd 11218 53 mm mm NNP cord-010119-t1x9gknd 11218 54 ) ) -RRB- cord-010119-t1x9gknd 11218 55 for for IN cord-010119-t1x9gknd 11218 56 ABO ABO NNP cord-010119-t1x9gknd 11218 57 / / SYM cord-010119-t1x9gknd 11218 58 Rh Rh NNP cord-010119-t1x9gknd 11218 59 testing testing NN cord-010119-t1x9gknd 11218 60 . . . cord-010119-t1x9gknd 11219 1 For for IN cord-010119-t1x9gknd 11219 2 8,750 8,750 CD cord-010119-t1x9gknd 11219 3 antibody antibody NN cord-010119-t1x9gknd 11219 4 screens screen NNS cord-010119-t1x9gknd 11219 5 , , , cord-010119-t1x9gknd 11219 6 automatic automatic JJ cord-010119-t1x9gknd 11219 7 validation validation NN cord-010119-t1x9gknd 11219 8 of of IN cord-010119-t1x9gknd 11219 9 results result NNS cord-010119-t1x9gknd 11219 10 would would MD cord-010119-t1x9gknd 11219 11 result result VB cord-010119-t1x9gknd 11219 12 in in IN cord-010119-t1x9gknd 11219 13 99.5 99.5 CD cord-010119-t1x9gknd 11219 14 % % NN cord-010119-t1x9gknd 11219 15 reduction reduction NN cord-010119-t1x9gknd 11219 16 in in IN cord-010119-t1x9gknd 11219 17 operator operator NN cord-010119-t1x9gknd 11219 18 touchpoints touchpoint NNS cord-010119-t1x9gknd 11219 19 ( ( -LRB- cord-010119-t1x9gknd 11219 20 p p NN cord-010119-t1x9gknd 11219 21 < < XX cord-010119-t1x9gknd 11219 22 0.001 0.001 CD cord-010119-t1x9gknd 11219 23 ) ) -RRB- cord-010119-t1x9gknd 11219 24 and and CC cord-010119-t1x9gknd 11219 25 a a DT cord-010119-t1x9gknd 11219 26 labor labor NN cord-010119-t1x9gknd 11219 27 savings saving NNS cord-010119-t1x9gknd 11219 28 of of IN cord-010119-t1x9gknd 11219 29 378 378 CD cord-010119-t1x9gknd 11219 30 minutes minute NNS cord-010119-t1x9gknd 11219 31 ( ( -LRB- cord-010119-t1x9gknd 11219 32 6:18 6:18 CD cord-010119-t1x9gknd 11219 33 hh hh NN cord-010119-t1x9gknd 11219 34 : : : cord-010119-t1x9gknd 11219 35 mm mm NNP cord-010119-t1x9gknd 11219 36 ) ) -RRB- cord-010119-t1x9gknd 11219 37 . . . cord-010119-t1x9gknd 11220 1 No no DT cord-010119-t1x9gknd 11220 2 false false JJ cord-010119-t1x9gknd 11220 3 positive positive JJ cord-010119-t1x9gknd 11220 4 or or CC cord-010119-t1x9gknd 11220 5 false false JJ cord-010119-t1x9gknd 11220 6 negative negative JJ cord-010119-t1x9gknd 11220 7 typing typing NN cord-010119-t1x9gknd 11220 8 results result NNS cord-010119-t1x9gknd 11220 9 or or CC cord-010119-t1x9gknd 11220 10 false false JJ cord-010119-t1x9gknd 11220 11 negative negative JJ cord-010119-t1x9gknd 11220 12 screenings screening NNS cord-010119-t1x9gknd 11220 13 occurred occur VBD cord-010119-t1x9gknd 11220 14 with with IN cord-010119-t1x9gknd 11220 15 results result NNS cord-010119-t1x9gknd 11220 16 auto auto NN cord-010119-t1x9gknd 11220 17 - - HYPH cord-010119-t1x9gknd 11220 18 verification verification NN cord-010119-t1x9gknd 11220 19 . . . cord-010119-t1x9gknd 11221 1 ( ( -LRB- cord-010119-t1x9gknd 11221 2 RBC RBC NNP cord-010119-t1x9gknd 11221 3 ) ) -RRB- cord-010119-t1x9gknd 11221 4 has have VBZ cord-010119-t1x9gknd 11221 5 remained remain VBN cord-010119-t1x9gknd 11221 6 , , , cord-010119-t1x9gknd 11221 7 and and CC cord-010119-t1x9gknd 11221 8 in in IN cord-010119-t1x9gknd 11221 9 fact fact NN cord-010119-t1x9gknd 11221 10 is be VBZ cord-010119-t1x9gknd 11221 11 proportionally proportionally RB cord-010119-t1x9gknd 11221 12 increasing increase VBG cord-010119-t1x9gknd 11221 13 while while IN cord-010119-t1x9gknd 11221 14 blood blood NN cord-010119-t1x9gknd 11221 15 usage usage NN cord-010119-t1x9gknd 11221 16 has have VBZ cord-010119-t1x9gknd 11221 17 notably notably RB cord-010119-t1x9gknd 11221 18 declined decline VBN cord-010119-t1x9gknd 11221 19 in in IN cord-010119-t1x9gknd 11221 20 the the DT cord-010119-t1x9gknd 11221 21 era era NN cord-010119-t1x9gknd 11221 22 of of IN cord-010119-t1x9gknd 11221 23 patient patient JJ cord-010119-t1x9gknd 11221 24 blood blood NN cord-010119-t1x9gknd 11221 25 management management NN cord-010119-t1x9gknd 11221 26 . . . cord-010119-t1x9gknd 11222 1 Over over IN cord-010119-t1x9gknd 11222 2 the the DT cord-010119-t1x9gknd 11222 3 past past JJ cord-010119-t1x9gknd 11222 4 2 2 CD cord-010119-t1x9gknd 11222 5 years year NNS cord-010119-t1x9gknd 11222 6 a a DT cord-010119-t1x9gknd 11222 7 steady steady JJ cord-010119-t1x9gknd 11222 8 increase increase NN cord-010119-t1x9gknd 11222 9 in in IN cord-010119-t1x9gknd 11222 10 demand demand NN cord-010119-t1x9gknd 11222 11 for for IN cord-010119-t1x9gknd 11222 12 O o NN cord-010119-t1x9gknd 11222 13 Neg Neg NNP cord-010119-t1x9gknd 11222 14 RBC RBC NNP cord-010119-t1x9gknd 11222 15 compared compare VBN cord-010119-t1x9gknd 11222 16 to to IN cord-010119-t1x9gknd 11222 17 other other JJ cord-010119-t1x9gknd 11222 18 blood blood NN cord-010119-t1x9gknd 11222 19 types type NNS cord-010119-t1x9gknd 11222 20 has have VBZ cord-010119-t1x9gknd 11222 21 been be VBN cord-010119-t1x9gknd 11222 22 observed observe VBN cord-010119-t1x9gknd 11222 23 at at IN cord-010119-t1x9gknd 11222 24 our -PRON- PRP$ cord-010119-t1x9gknd 11222 25 blood blood NN cord-010119-t1x9gknd 11222 26 center center NN cord-010119-t1x9gknd 11222 27 . . . cord-010119-t1x9gknd 11223 1 Utilization utilization NN cord-010119-t1x9gknd 11223 2 metrics metric NNS cord-010119-t1x9gknd 11223 3 for for IN cord-010119-t1x9gknd 11223 4 hospital hospital NN cord-010119-t1x9gknd 11223 5 customers customer NNS cord-010119-t1x9gknd 11223 6 are be VBP cord-010119-t1x9gknd 11223 7 monitored monitor VBN cord-010119-t1x9gknd 11223 8 monthly monthly RB cord-010119-t1x9gknd 11223 9 for for IN cord-010119-t1x9gknd 11223 10 overall overall RB cord-010119-t1x9gknd 11223 11 trending trend VBG cord-010119-t1x9gknd 11223 12 and and CC cord-010119-t1x9gknd 11223 13 forecasting forecasting NN cord-010119-t1x9gknd 11223 14 and and CC cord-010119-t1x9gknd 11223 15 the the DT cord-010119-t1x9gknd 11223 16 data datum NNS cord-010119-t1x9gknd 11223 17 shared share VBN cord-010119-t1x9gknd 11223 18 with with IN cord-010119-t1x9gknd 11223 19 them -PRON- PRP cord-010119-t1x9gknd 11223 20 during during IN cord-010119-t1x9gknd 11223 21 regular regular JJ cord-010119-t1x9gknd 11223 22 visits visit NNS cord-010119-t1x9gknd 11223 23 . . . cord-010119-t1x9gknd 11224 1 Despite despite IN cord-010119-t1x9gknd 11224 2 heightening heighten VBG cord-010119-t1x9gknd 11224 3 awareness awareness NN cord-010119-t1x9gknd 11224 4 , , , cord-010119-t1x9gknd 11224 5 percent percent NN cord-010119-t1x9gknd 11224 6 O o NN cord-010119-t1x9gknd 11224 7 Neg Neg NNP cord-010119-t1x9gknd 11224 8 RBC RBC NNP cord-010119-t1x9gknd 11224 9 sales sale NNS cord-010119-t1x9gknd 11224 10 continued continue VBD cord-010119-t1x9gknd 11224 11 to to TO cord-010119-t1x9gknd 11224 12 rise rise VB cord-010119-t1x9gknd 11224 13 by by IN cord-010119-t1x9gknd 11224 14 1 1 CD cord-010119-t1x9gknd 11224 15 % % NN cord-010119-t1x9gknd 11224 16 annually annually RB cord-010119-t1x9gknd 11224 17 and and CC cord-010119-t1x9gknd 11224 18 peaked peak VBD cord-010119-t1x9gknd 11224 19 at at IN cord-010119-t1x9gknd 11224 20 16 16 CD cord-010119-t1x9gknd 11224 21 % % NN cord-010119-t1x9gknd 11224 22 in in IN cord-010119-t1x9gknd 11224 23 mid mid JJ cord-010119-t1x9gknd 11224 24 2016 2016 CD cord-010119-t1x9gknd 11224 25 . . . cord-010119-t1x9gknd 11225 1 To to TO cord-010119-t1x9gknd 11225 2 better well RBR cord-010119-t1x9gknd 11225 3 understand understand VB cord-010119-t1x9gknd 11225 4 this this DT cord-010119-t1x9gknd 11225 5 increased increase VBN cord-010119-t1x9gknd 11225 6 demand demand NN cord-010119-t1x9gknd 11225 7 a a DT cord-010119-t1x9gknd 11225 8 survey survey NN cord-010119-t1x9gknd 11225 9 was be VBD cord-010119-t1x9gknd 11225 10 conducted conduct VBN cord-010119-t1x9gknd 11225 11 to to TO cord-010119-t1x9gknd 11225 12 gather gather VB cord-010119-t1x9gknd 11225 13 insight insight NN cord-010119-t1x9gknd 11225 14 for for IN cord-010119-t1x9gknd 11225 15 improved improved JJ cord-010119-t1x9gknd 11225 16 utilization utilization NN cord-010119-t1x9gknd 11225 17 . . . cord-010119-t1x9gknd 11226 1 We -PRON- PRP cord-010119-t1x9gknd 11226 2 speculated speculate VBD cord-010119-t1x9gknd 11226 3 that that IN cord-010119-t1x9gknd 11226 4 during during IN cord-010119-t1x9gknd 11226 5 the the DT cord-010119-t1x9gknd 11226 6 survey survey NN cord-010119-t1x9gknd 11226 7 an an DT cord-010119-t1x9gknd 11226 8 observer observer NN cord-010119-t1x9gknd 11226 9 effect effect NN cord-010119-t1x9gknd 11226 10 , , , cord-010119-t1x9gknd 11226 11 or or CC cord-010119-t1x9gknd 11226 12 change change VB cord-010119-t1x9gknd 11226 13 in in IN cord-010119-t1x9gknd 11226 14 the the DT cord-010119-t1x9gknd 11226 15 staff staff NN cord-010119-t1x9gknd 11226 16 behavior behavior NN cord-010119-t1x9gknd 11226 17 , , , cord-010119-t1x9gknd 11226 18 would would MD cord-010119-t1x9gknd 11226 19 result result VB cord-010119-t1x9gknd 11226 20 in in IN cord-010119-t1x9gknd 11226 21 reduction reduction NN cord-010119-t1x9gknd 11226 22 of of IN cord-010119-t1x9gknd 11226 23 O o NN cord-010119-t1x9gknd 11226 24 Neg Neg NNP cord-010119-t1x9gknd 11226 25 RBC RBC NNP cord-010119-t1x9gknd 11226 26 sales sale NNS cord-010119-t1x9gknd 11226 27 . . . cord-010119-t1x9gknd 11227 1 Study Study NNP cord-010119-t1x9gknd 11227 2 Design Design NNP cord-010119-t1x9gknd 11227 3 / / SYM cord-010119-t1x9gknd 11227 4 Methods method NNS cord-010119-t1x9gknd 11227 5 : : : cord-010119-t1x9gknd 11227 6 A a DT cord-010119-t1x9gknd 11227 7 tie tie NN cord-010119-t1x9gknd 11227 8 tag tag NN cord-010119-t1x9gknd 11227 9 was be VBD cord-010119-t1x9gknd 11227 10 designed design VBN cord-010119-t1x9gknd 11227 11 as as IN cord-010119-t1x9gknd 11227 12 a a DT cord-010119-t1x9gknd 11227 13 survey survey NN cord-010119-t1x9gknd 11227 14 tool tool NN cord-010119-t1x9gknd 11227 15 and and CC cord-010119-t1x9gknd 11227 16 attached attach VBN cord-010119-t1x9gknd 11227 17 to to IN cord-010119-t1x9gknd 11227 18 each each DT cord-010119-t1x9gknd 11227 19 O o UH cord-010119-t1x9gknd 11227 20 Neg Neg NNP cord-010119-t1x9gknd 11227 21 RBC RBC NNP cord-010119-t1x9gknd 11227 22 distributed distribute VBN cord-010119-t1x9gknd 11227 23 to to IN cord-010119-t1x9gknd 11227 24 hospital hospital NN cord-010119-t1x9gknd 11227 25 customers customer NNS cord-010119-t1x9gknd 11227 26 for for IN cord-010119-t1x9gknd 11227 27 an an DT cord-010119-t1x9gknd 11227 28 8week 8week CD cord-010119-t1x9gknd 11227 29 period period NN cord-010119-t1x9gknd 11227 30 in in IN cord-010119-t1x9gknd 11227 31 late late JJ cord-010119-t1x9gknd 11227 32 2016 2016 CD cord-010119-t1x9gknd 11227 33 . . . cord-010119-t1x9gknd 11228 1 Hospital hospital NN cord-010119-t1x9gknd 11228 2 transfusion transfusion NN cord-010119-t1x9gknd 11228 3 service service NN cord-010119-t1x9gknd 11228 4 staff staff NN cord-010119-t1x9gknd 11228 5 were be VBD cord-010119-t1x9gknd 11228 6 asked ask VBN cord-010119-t1x9gknd 11228 7 to to TO cord-010119-t1x9gknd 11228 8 record record VB cord-010119-t1x9gknd 11228 9 the the DT cord-010119-t1x9gknd 11228 10 final final JJ cord-010119-t1x9gknd 11228 11 disposition disposition NN cord-010119-t1x9gknd 11228 12 of of IN cord-010119-t1x9gknd 11228 13 the the DT cord-010119-t1x9gknd 11228 14 O O NNP cord-010119-t1x9gknd 11228 15 Neg Neg NNP cord-010119-t1x9gknd 11228 16 RBC RBC NNP cord-010119-t1x9gknd 11228 17 ( ( -LRB- cord-010119-t1x9gknd 11228 18 transfused transfuse VBN cord-010119-t1x9gknd 11228 19 , , , cord-010119-t1x9gknd 11228 20 wasted waste VBN cord-010119-t1x9gknd 11228 21 , , , cord-010119-t1x9gknd 11228 22 returned return VBD cord-010119-t1x9gknd 11228 23 ) ) -RRB- cord-010119-t1x9gknd 11228 24 on on IN cord-010119-t1x9gknd 11228 25 the the DT cord-010119-t1x9gknd 11228 26 tie tie NN cord-010119-t1x9gknd 11228 27 tag tag NN cord-010119-t1x9gknd 11228 28 . . . cord-010119-t1x9gknd 11229 1 Information information NN cord-010119-t1x9gknd 11229 2 on on IN cord-010119-t1x9gknd 11229 3 the the DT cord-010119-t1x9gknd 11229 4 survey survey NN cord-010119-t1x9gknd 11229 5 objective objective NN cord-010119-t1x9gknd 11229 6 and and CC cord-010119-t1x9gknd 11229 7 instructions instruction NNS cord-010119-t1x9gknd 11229 8 for for IN cord-010119-t1x9gknd 11229 9 tie tie NN cord-010119-t1x9gknd 11229 10 tag tag NN cord-010119-t1x9gknd 11229 11 completion completion NN cord-010119-t1x9gknd 11229 12 were be VBD cord-010119-t1x9gknd 11229 13 communicated communicate VBN cord-010119-t1x9gknd 11229 14 via via IN cord-010119-t1x9gknd 11229 15 customer customer NN cord-010119-t1x9gknd 11229 16 meetings meeting NNS cord-010119-t1x9gknd 11229 17 , , , cord-010119-t1x9gknd 11229 18 emails email NNS cord-010119-t1x9gknd 11229 19 and and CC cord-010119-t1x9gknd 11229 20 reminders reminder NNS cord-010119-t1x9gknd 11229 21 sent send VBN cord-010119-t1x9gknd 11229 22 by by IN cord-010119-t1x9gknd 11229 23 blood blood NN cord-010119-t1x9gknd 11229 24 center center NN cord-010119-t1x9gknd 11229 25 drivers driver NNS cord-010119-t1x9gknd 11229 26 . . . cord-010119-t1x9gknd 11230 1 Completed complete VBN cord-010119-t1x9gknd 11230 2 tags tag NNS cord-010119-t1x9gknd 11230 3 were be VBD cord-010119-t1x9gknd 11230 4 returned return VBN cord-010119-t1x9gknd 11230 5 to to IN cord-010119-t1x9gknd 11230 6 the the DT cord-010119-t1x9gknd 11230 7 blood blood NN cord-010119-t1x9gknd 11230 8 center center NN cord-010119-t1x9gknd 11230 9 . . . cord-010119-t1x9gknd 11231 1 Customers customer NNS cord-010119-t1x9gknd 11231 2 are be VBP cord-010119-t1x9gknd 11231 3 allowed allow VBN cord-010119-t1x9gknd 11231 4 to to TO cord-010119-t1x9gknd 11231 5 return return VB cord-010119-t1x9gknd 11231 6 RBC RBC NNP cord-010119-t1x9gknd 11231 7 units unit NNS cord-010119-t1x9gknd 11231 8 with with IN cord-010119-t1x9gknd 11231 9 greater great JJR cord-010119-t1x9gknd 11231 10 than than IN cord-010119-t1x9gknd 11231 11 10 10 CD cord-010119-t1x9gknd 11231 12 day day NN cord-010119-t1x9gknd 11231 13 shelf shelf NN cord-010119-t1x9gknd 11231 14 life life NN cord-010119-t1x9gknd 11231 15 remaining remain VBG cord-010119-t1x9gknd 11231 16 . . . cord-010119-t1x9gknd 11232 1 Units unit NNS cord-010119-t1x9gknd 11232 2 with with IN cord-010119-t1x9gknd 11232 3 tie tie NN cord-010119-t1x9gknd 11232 4 tags tag NNS cord-010119-t1x9gknd 11232 5 attached attach VBN cord-010119-t1x9gknd 11232 6 were be VBD cord-010119-t1x9gknd 11232 7 in in IN cord-010119-t1x9gknd 11232 8 hospital hospital NN cord-010119-t1x9gknd 11232 9 inventories inventory NNS cord-010119-t1x9gknd 11232 10 for for IN cord-010119-t1x9gknd 11232 11 up up IN cord-010119-t1x9gknd 11232 12 to to TO cord-010119-t1x9gknd 11232 13 3 3 CD cord-010119-t1x9gknd 11232 14 months month NNS cord-010119-t1x9gknd 11232 15 due due IN cord-010119-t1x9gknd 11232 16 to to IN cord-010119-t1x9gknd 11232 17 the the DT cord-010119-t1x9gknd 11232 18 shelf shelf NN cord-010119-t1x9gknd 11232 19 life life NN cord-010119-t1x9gknd 11232 20 of of IN cord-010119-t1x9gknd 11232 21 RBC RBC NNP cord-010119-t1x9gknd 11232 22 . . . cord-010119-t1x9gknd 11233 1 Return return NN cord-010119-t1x9gknd 11233 2 rates rate NNS cord-010119-t1x9gknd 11233 3 and and CC cord-010119-t1x9gknd 11233 4 percent percent NN cord-010119-t1x9gknd 11233 5 of of IN cord-010119-t1x9gknd 11233 6 net net JJ cord-010119-t1x9gknd 11233 7 sales sale NNS cord-010119-t1x9gknd 11233 8 ( ( -LRB- cord-010119-t1x9gknd 11233 9 gross gross JJ cord-010119-t1x9gknd 11233 10 sales sale NNS cord-010119-t1x9gknd 11233 11 minus minus NN cord-010119-t1x9gknd 11233 12 returns return NNS cord-010119-t1x9gknd 11233 13 ) ) -RRB- cord-010119-t1x9gknd 11233 14 by by IN cord-010119-t1x9gknd 11233 15 ABO ABO NNP cord-010119-t1x9gknd 11233 16 / / SYM cord-010119-t1x9gknd 11233 17 Rh Rh NNP cord-010119-t1x9gknd 11233 18 type type NN cord-010119-t1x9gknd 11233 19 were be VBD cord-010119-t1x9gknd 11233 20 tracked track VBN cord-010119-t1x9gknd 11233 21 monthly monthly RB cord-010119-t1x9gknd 11233 22 before before RB cord-010119-t1x9gknd 11233 23 , , , cord-010119-t1x9gknd 11233 24 during during IN cord-010119-t1x9gknd 11233 25 and and CC cord-010119-t1x9gknd 11233 26 after after IN cord-010119-t1x9gknd 11233 27 the the DT cord-010119-t1x9gknd 11233 28 survey survey NN cord-010119-t1x9gknd 11233 29 . . . cord-010119-t1x9gknd 11234 1 Results result NNS cord-010119-t1x9gknd 11234 2 / / SYM cord-010119-t1x9gknd 11234 3 Findings finding NNS cord-010119-t1x9gknd 11234 4 : : : cord-010119-t1x9gknd 11235 1 Participation participation NN cord-010119-t1x9gknd 11235 2 was be VBD cord-010119-t1x9gknd 11235 3 100 100 CD cord-010119-t1x9gknd 11235 4 % % NN cord-010119-t1x9gknd 11235 5 of of IN cord-010119-t1x9gknd 11235 6 the the DT cord-010119-t1x9gknd 11235 7 56 56 CD cord-010119-t1x9gknd 11235 8 hospitals hospital NNS cord-010119-t1x9gknd 11235 9 surveyed survey VBN cord-010119-t1x9gknd 11235 10 . . . cord-010119-t1x9gknd 11236 1 Mean mean JJ cord-010119-t1x9gknd 11236 2 percent percent NN cord-010119-t1x9gknd 11236 3 O o NN cord-010119-t1x9gknd 11236 4 Neg Neg NNP cord-010119-t1x9gknd 11236 5 RBC RBC NNP cord-010119-t1x9gknd 11236 6 gross gross JJ cord-010119-t1x9gknd 11236 7 sales sale NNS cord-010119-t1x9gknd 11236 8 for for IN cord-010119-t1x9gknd 11236 9 a a DT cord-010119-t1x9gknd 11236 10 3 3 CD cord-010119-t1x9gknd 11236 11 month month NN cord-010119-t1x9gknd 11236 12 period period NN cord-010119-t1x9gknd 11236 13 before before RB cord-010119-t1x9gknd 11236 14 , , , cord-010119-t1x9gknd 11236 15 during during IN cord-010119-t1x9gknd 11236 16 , , , cord-010119-t1x9gknd 11236 17 and and CC cord-010119-t1x9gknd 11236 18 after after IN cord-010119-t1x9gknd 11236 19 the the DT cord-010119-t1x9gknd 11236 20 survey survey NN cord-010119-t1x9gknd 11236 21 was be VBD cord-010119-t1x9gknd 11236 22 16.6 16.6 CD cord-010119-t1x9gknd 11236 23 % % NN cord-010119-t1x9gknd 11236 24 , , , cord-010119-t1x9gknd 11236 25 16.0 16.0 CD cord-010119-t1x9gknd 11236 26 % % NN cord-010119-t1x9gknd 11236 27 and and CC cord-010119-t1x9gknd 11236 28 16.5 16.5 CD cord-010119-t1x9gknd 11236 29 % % NN cord-010119-t1x9gknd 11236 30 , , , cord-010119-t1x9gknd 11236 31 respectively respectively RB cord-010119-t1x9gknd 11236 32 . . . cord-010119-t1x9gknd 11237 1 Mean mean JJ cord-010119-t1x9gknd 11237 2 percent percent NN cord-010119-t1x9gknd 11237 3 O o NN cord-010119-t1x9gknd 11238 1 Neg Neg NNP cord-010119-t1x9gknd 11238 2 net net JJ cord-010119-t1x9gknd 11238 3 sales sale NNS cord-010119-t1x9gknd 11238 4 during during IN cord-010119-t1x9gknd 11238 5 the the DT cord-010119-t1x9gknd 11238 6 3-month 3-month CD cord-010119-t1x9gknd 11238 7 survey survey NN cord-010119-t1x9gknd 11238 8 fell fall VBD cord-010119-t1x9gknd 11238 9 to to IN cord-010119-t1x9gknd 11238 10 13.5 13.5 CD cord-010119-t1x9gknd 11238 11 % % NN cord-010119-t1x9gknd 11238 12 compared compare VBN cord-010119-t1x9gknd 11238 13 to to IN cord-010119-t1x9gknd 11238 14 an an DT cord-010119-t1x9gknd 11238 15 average average NN cord-010119-t1x9gknd 11238 16 of of IN cord-010119-t1x9gknd 11238 17 15.4 15.4 CD cord-010119-t1x9gknd 11238 18 % % NN cord-010119-t1x9gknd 11238 19 in in IN cord-010119-t1x9gknd 11238 20 the the DT cord-010119-t1x9gknd 11238 21 3 3 CD cord-010119-t1x9gknd 11238 22 months month NNS cord-010119-t1x9gknd 11238 23 prior prior RB cord-010119-t1x9gknd 11238 24 . . . cord-010119-t1x9gknd 11239 1 During during IN cord-010119-t1x9gknd 11239 2 the the DT cord-010119-t1x9gknd 11239 3 3-month 3-month CD cord-010119-t1x9gknd 11239 4 survey survey NN cord-010119-t1x9gknd 11239 5 period period NN cord-010119-t1x9gknd 11239 6 O o NN cord-010119-t1x9gknd 11239 7 Neg Neg NNP cord-010119-t1x9gknd 11239 8 RBC RBC NNP cord-010119-t1x9gknd 11239 9 monthly monthly JJ cord-010119-t1x9gknd 11239 10 return return NN cord-010119-t1x9gknd 11239 11 rate rate NN cord-010119-t1x9gknd 11239 12 increased increase VBD cord-010119-t1x9gknd 11239 13 to to IN cord-010119-t1x9gknd 11239 14 an an DT cord-010119-t1x9gknd 11239 15 average average NN cord-010119-t1x9gknd 11239 16 of of IN cord-010119-t1x9gknd 11239 17 28.4 28.4 CD cord-010119-t1x9gknd 11239 18 % % NN cord-010119-t1x9gknd 11239 19 compared compare VBN cord-010119-t1x9gknd 11239 20 to to IN cord-010119-t1x9gknd 11239 21 an an DT cord-010119-t1x9gknd 11239 22 average average NN cord-010119-t1x9gknd 11239 23 of of IN cord-010119-t1x9gknd 11239 24 23.0 23.0 CD cord-010119-t1x9gknd 11239 25 % % NN cord-010119-t1x9gknd 11239 26 in in IN cord-010119-t1x9gknd 11239 27 the the DT cord-010119-t1x9gknd 11239 28 3 3 CD cord-010119-t1x9gknd 11239 29 months month NNS cord-010119-t1x9gknd 11239 30 prior prior RB cord-010119-t1x9gknd 11239 31 . . . cord-010119-t1x9gknd 11240 1 For for IN cord-010119-t1x9gknd 11240 2 the the DT cord-010119-t1x9gknd 11240 3 3 3 CD cord-010119-t1x9gknd 11240 4 months month NNS cord-010119-t1x9gknd 11240 5 after after IN cord-010119-t1x9gknd 11240 6 the the DT cord-010119-t1x9gknd 11240 7 survey survey NN cord-010119-t1x9gknd 11240 8 the the DT cord-010119-t1x9gknd 11240 9 average average JJ cord-010119-t1x9gknd 11240 10 O o NN cord-010119-t1x9gknd 11240 11 Neg Neg NNP cord-010119-t1x9gknd 11240 12 RBC RBC NNP cord-010119-t1x9gknd 11240 13 return return NN cord-010119-t1x9gknd 11240 14 rate rate NN cord-010119-t1x9gknd 11240 15 further further RB cord-010119-t1x9gknd 11240 16 increased increase VBD cord-010119-t1x9gknd 11240 17 to to IN cord-010119-t1x9gknd 11240 18 28.9 28.9 CD cord-010119-t1x9gknd 11240 19 % % NN cord-010119-t1x9gknd 11240 20 while while IN cord-010119-t1x9gknd 11240 21 mean mean JJ cord-010119-t1x9gknd 11240 22 percent percent NN cord-010119-t1x9gknd 11240 23 O o NN cord-010119-t1x9gknd 11240 24 Neg Neg NNP cord-010119-t1x9gknd 11240 25 RBC RBC NNP cord-010119-t1x9gknd 11240 26 net net JJ cord-010119-t1x9gknd 11240 27 sales sale NNS cord-010119-t1x9gknd 11240 28 trended trend VBD cord-010119-t1x9gknd 11240 29 slightly slightly RB cord-010119-t1x9gknd 11240 30 upward upward RB cord-010119-t1x9gknd 11240 31 to to IN cord-010119-t1x9gknd 11240 32 14.1 14.1 CD cord-010119-t1x9gknd 11240 33 % % NN cord-010119-t1x9gknd 11240 34 . . . cord-010119-t1x9gknd 11241 1 When when WRB cord-010119-t1x9gknd 11241 2 customer customer NN cord-010119-t1x9gknd 11241 3 hospitals hospital NNS cord-010119-t1x9gknd 11241 4 were be VBD cord-010119-t1x9gknd 11241 5 queried query VBN cord-010119-t1x9gknd 11241 6 whether whether IN cord-010119-t1x9gknd 11241 7 any any DT cord-010119-t1x9gknd 11241 8 process process NN cord-010119-t1x9gknd 11241 9 changes change NNS cord-010119-t1x9gknd 11241 10 occurred occur VBD cord-010119-t1x9gknd 11241 11 , , , cord-010119-t1x9gknd 11241 12 no no DT cord-010119-t1x9gknd 11241 13 major major JJ cord-010119-t1x9gknd 11241 14 changes change NNS cord-010119-t1x9gknd 11241 15 to to IN cord-010119-t1x9gknd 11241 16 policy policy NN cord-010119-t1x9gknd 11241 17 or or CC cord-010119-t1x9gknd 11241 18 inventory inventory NN cord-010119-t1x9gknd 11241 19 levels level NNS cord-010119-t1x9gknd 11241 20 were be VBD cord-010119-t1x9gknd 11241 21 reported report VBN cord-010119-t1x9gknd 11241 22 . . . cord-010119-t1x9gknd 11242 1 Conclusion conclusion NN cord-010119-t1x9gknd 11242 2 : : : cord-010119-t1x9gknd 11243 1 During during IN cord-010119-t1x9gknd 11243 2 and and CC cord-010119-t1x9gknd 11243 3 after after IN cord-010119-t1x9gknd 11243 4 the the DT cord-010119-t1x9gknd 11243 5 survey survey NN cord-010119-t1x9gknd 11243 6 percent percent NN cord-010119-t1x9gknd 11243 7 O o NN cord-010119-t1x9gknd 11243 8 Neg Neg NNP cord-010119-t1x9gknd 11243 9 RBC RBC NNP cord-010119-t1x9gknd 11243 10 gross gross JJ cord-010119-t1x9gknd 11243 11 sales sale NNS cord-010119-t1x9gknd 11243 12 was be VBD cord-010119-t1x9gknd 11243 13 fairly fairly RB cord-010119-t1x9gknd 11243 14 constant constant JJ cord-010119-t1x9gknd 11243 15 indicating indicate VBG cord-010119-t1x9gknd 11243 16 that that DT cord-010119-t1x9gknd 11243 17 target target NN cord-010119-t1x9gknd 11243 18 inventory inventory NN cord-010119-t1x9gknd 11243 19 levels level NNS cord-010119-t1x9gknd 11243 20 and and CC cord-010119-t1x9gknd 11243 21 transfusion transfusion NN cord-010119-t1x9gknd 11243 22 service service NN cord-010119-t1x9gknd 11243 23 staff staff NN cord-010119-t1x9gknd 11243 24 ordering ordering NN cord-010119-t1x9gknd 11243 25 practices practice NNS cord-010119-t1x9gknd 11243 26 remained remain VBD cord-010119-t1x9gknd 11243 27 unchanged unchanged JJ cord-010119-t1x9gknd 11243 28 . . . cord-010119-t1x9gknd 11244 1 However however RB cord-010119-t1x9gknd 11244 2 , , , cord-010119-t1x9gknd 11244 3 during during IN cord-010119-t1x9gknd 11244 4 the the DT cord-010119-t1x9gknd 11244 5 same same JJ cord-010119-t1x9gknd 11244 6 period period NN cord-010119-t1x9gknd 11244 7 the the DT cord-010119-t1x9gknd 11244 8 increase increase NN cord-010119-t1x9gknd 11244 9 in in IN cord-010119-t1x9gknd 11244 10 O o NN cord-010119-t1x9gknd 11244 11 Neg Neg NNP cord-010119-t1x9gknd 11244 12 RBC RBC NNP cord-010119-t1x9gknd 11244 13 return return NN cord-010119-t1x9gknd 11244 14 rate rate NN cord-010119-t1x9gknd 11244 15 and and CC cord-010119-t1x9gknd 11244 16 corresponding corresponding JJ cord-010119-t1x9gknd 11244 17 decline decline NN cord-010119-t1x9gknd 11244 18 in in IN cord-010119-t1x9gknd 11244 19 percent percent NN cord-010119-t1x9gknd 11244 20 net net JJ cord-010119-t1x9gknd 11244 21 sales sale NNS cord-010119-t1x9gknd 11244 22 suggests suggest VBZ cord-010119-t1x9gknd 11244 23 improved improve VBN cord-010119-t1x9gknd 11244 24 O O NNP cord-010119-t1x9gknd 11244 25 Neg Neg NNP cord-010119-t1x9gknd 11244 26 RBC RBC NNP cord-010119-t1x9gknd 11244 27 utilization utilization NN cord-010119-t1x9gknd 11244 28 . . . cord-010119-t1x9gknd 11245 1 Increased increase VBN cord-010119-t1x9gknd 11245 2 awareness awareness NN cord-010119-t1x9gknd 11245 3 from from IN cord-010119-t1x9gknd 11245 4 participating participate VBG cord-010119-t1x9gknd 11245 5 in in IN cord-010119-t1x9gknd 11245 6 the the DT cord-010119-t1x9gknd 11245 7 survey survey NN cord-010119-t1x9gknd 11245 8 and and CC cord-010119-t1x9gknd 11245 9 staff staff NN cord-010119-t1x9gknd 11245 10 knowing know VBG cord-010119-t1x9gknd 11245 11 they -PRON- PRP cord-010119-t1x9gknd 11245 12 were be VBD cord-010119-t1x9gknd 11245 13 being be VBG cord-010119-t1x9gknd 11245 14 observed observe VBN cord-010119-t1x9gknd 11245 15 likely likely RB cord-010119-t1x9gknd 11245 16 played play VBD cord-010119-t1x9gknd 11245 17 a a DT cord-010119-t1x9gknd 11245 18 role role NN cord-010119-t1x9gknd 11245 19 in in IN cord-010119-t1x9gknd 11245 20 the the DT cord-010119-t1x9gknd 11245 21 lowering lowering NN cord-010119-t1x9gknd 11245 22 of of IN cord-010119-t1x9gknd 11245 23 percent percent NN cord-010119-t1x9gknd 11245 24 O o NN cord-010119-t1x9gknd 11245 25 Neg Neg NNP cord-010119-t1x9gknd 11245 26 RBC RBC NNP cord-010119-t1x9gknd 11245 27 net net JJ cord-010119-t1x9gknd 11245 28 sales sale NNS cord-010119-t1x9gknd 11245 29 . . . cord-010119-t1x9gknd 11246 1 Tracking tracking NN cord-010119-t1x9gknd 11246 2 of of IN cord-010119-t1x9gknd 11246 3 monthly monthly JJ cord-010119-t1x9gknd 11246 4 metrics metric NNS cord-010119-t1x9gknd 11246 5 will will MD cord-010119-t1x9gknd 11246 6 provide provide VB cord-010119-t1x9gknd 11246 7 ongoing ongoing JJ cord-010119-t1x9gknd 11246 8 review review NN cord-010119-t1x9gknd 11246 9 to to TO cord-010119-t1x9gknd 11246 10 determine determine VB cord-010119-t1x9gknd 11246 11 if if IN cord-010119-t1x9gknd 11246 12 the the DT cord-010119-t1x9gknd 11246 13 effect effect NN cord-010119-t1x9gknd 11246 14 is be VBZ cord-010119-t1x9gknd 11246 15 transient transient JJ cord-010119-t1x9gknd 11246 16 or or CC cord-010119-t1x9gknd 11246 17 sustained sustained JJ cord-010119-t1x9gknd 11246 18 and and CC cord-010119-t1x9gknd 11246 19 identify identify VB cord-010119-t1x9gknd 11246 20 other other JJ cord-010119-t1x9gknd 11246 21 opportunities opportunity NNS cord-010119-t1x9gknd 11246 22 for for IN cord-010119-t1x9gknd 11246 23 improving improve VBG cord-010119-t1x9gknd 11246 24 O O NNP cord-010119-t1x9gknd 11246 25 Neg Neg NNP cord-010119-t1x9gknd 11246 26 RBC RBC NNP cord-010119-t1x9gknd 11246 27 utilization utilization NN cord-010119-t1x9gknd 11246 28 . . . cord-010119-t1x9gknd 11247 1 Acoustophoretic Acoustophoretic NNP cord-010119-t1x9gknd 11247 2 Separation Separation NNP cord-010119-t1x9gknd 11247 3 of of IN cord-010119-t1x9gknd 11247 4 Platelets Platelets NNPS cord-010119-t1x9gknd 11247 5 from from IN cord-010119-t1x9gknd 11247 6 Whole whole JJ cord-010119-t1x9gknd 11247 7 Blood blood NN cord-010119-t1x9gknd 11247 8 : : : cord-010119-t1x9gknd 11248 1 A a DT cord-010119-t1x9gknd 11248 2 Relevant relevant JJ cord-010119-t1x9gknd 11248 3 and and CC cord-010119-t1x9gknd 11248 4 Practical practical JJ cord-010119-t1x9gknd 11248 5 Alternative Alternative NNP cord-010119-t1x9gknd 11248 6 to to IN cord-010119-t1x9gknd 11248 7 Centrifugation Centrifugation NNP cord-010119-t1x9gknd 11248 8 Pierre Pierre NNP cord-010119-t1x9gknd 11248 9 Bohec Bohec NNP cord-010119-t1x9gknd 11249 1 * * NFP cord-010119-t1x9gknd 11249 2 1 1 CD cord-010119-t1x9gknd 11249 3 , , , cord-010119-t1x9gknd 11249 4 Jeremie Jeremie NNP cord-010119-t1x9gknd 11249 5 Gachelin Gachelin NNP cord-010119-t1x9gknd 11249 6 1 1 CD cord-010119-t1x9gknd 11249 7 , , , cord-010119-t1x9gknd 11249 8 Veronique Veronique NNP cord-010119-t1x9gknd 11249 9 Ollivier Ollivier NNP cord-010119-t1x9gknd 11249 10 2 2 CD cord-010119-t1x9gknd 11249 11 , , , cord-010119-t1x9gknd 11249 12 Thibaut Thibaut NNP cord-010119-t1x9gknd 11249 13 Mutin Mutin NNP cord-010119-t1x9gknd 11249 14 1 1 CD cord-010119-t1x9gknd 11249 15 , , , cord-010119-t1x9gknd 11249 16 Xavier Xavier NNP cord-010119-t1x9gknd 11249 17 Telot Telot NNP cord-010119-t1x9gknd 11249 18 1 1 CD cord-010119-t1x9gknd 11249 19 , , , cord-010119-t1x9gknd 11249 20 Benoit Benoit NNP cord-010119-t1x9gknd 11249 21 Ho Ho NNP cord-010119-t1x9gknd 11249 22 Tin Tin NNP cord-010119-t1x9gknd 11249 23 Noe Noe NNP cord-010119-t1x9gknd 11249 24 2 2 CD cord-010119-t1x9gknd 11249 25 and and CC cord-010119-t1x9gknd 11249 26 Sandra Sandra NNP cord-010119-t1x9gknd 11249 27 Sanfilippo Sanfilippo NNP cord-010119-t1x9gknd 11249 28 1 1 CD cord-010119-t1x9gknd 11249 29 . . . cord-010119-t1x9gknd 11250 1 1 1 LS cord-010119-t1x9gknd 11251 1 Aenitis Aenitis NNP cord-010119-t1x9gknd 11251 2 Technologies Technologies NNP cord-010119-t1x9gknd 11251 3 , , , cord-010119-t1x9gknd 11251 4 2 2 CD cord-010119-t1x9gknd 11251 5 Hôpital Hôpital NNP cord-010119-t1x9gknd 11251 6 Bichat Bichat NNP cord-010119-t1x9gknd 11251 7 , , , cord-010119-t1x9gknd 11251 8 INSERM INSERM NNP cord-010119-t1x9gknd 11251 9 U1148 U1148 NNP cord-010119-t1x9gknd 11251 10 Background Background NNP cord-010119-t1x9gknd 11251 11 / / SYM cord-010119-t1x9gknd 11251 12 Case Case NNP cord-010119-t1x9gknd 11251 13 Studies Studies NNPS cord-010119-t1x9gknd 11251 14 : : : cord-010119-t1x9gknd 11251 15 Shear shear NN cord-010119-t1x9gknd 11251 16 - - HYPH cord-010119-t1x9gknd 11251 17 induced induce VBN cord-010119-t1x9gknd 11251 18 platelet platelet NN cord-010119-t1x9gknd 11251 19 activation activation NN cord-010119-t1x9gknd 11251 20 is be VBZ cord-010119-t1x9gknd 11251 21 an an DT cord-010119-t1x9gknd 11251 22 unwanted unwanted JJ cord-010119-t1x9gknd 11251 23 side side NN cord-010119-t1x9gknd 11251 24 effect effect NN cord-010119-t1x9gknd 11251 25 of of IN cord-010119-t1x9gknd 11251 26 the the DT cord-010119-t1x9gknd 11251 27 centrifugation centrifugation NN cord-010119-t1x9gknd 11251 28 - - HYPH cord-010119-t1x9gknd 11251 29 based base VBN cord-010119-t1x9gknd 11251 30 procedure procedure NN cord-010119-t1x9gknd 11251 31 currently currently RB cord-010119-t1x9gknd 11251 32 used use VBN cord-010119-t1x9gknd 11251 33 in in IN cord-010119-t1x9gknd 11251 34 blood blood NN cord-010119-t1x9gknd 11251 35 banks bank NNS cord-010119-t1x9gknd 11251 36 to to TO cord-010119-t1x9gknd 11251 37 prepare prepare VB cord-010119-t1x9gknd 11251 38 platelet platelet NN cord-010119-t1x9gknd 11251 39 concentrates concentrate NNS cord-010119-t1x9gknd 11251 40 . . . cord-010119-t1x9gknd 11252 1 Transfusion transfusion NN cord-010119-t1x9gknd 11252 2 of of IN cord-010119-t1x9gknd 11252 3 partly partly RB cord-010119-t1x9gknd 11252 4 activated activate VBN cord-010119-t1x9gknd 11252 5 platelets platelet NNS cord-010119-t1x9gknd 11252 6 could could MD cord-010119-t1x9gknd 11252 7 indeed indeed RB cord-010119-t1x9gknd 11252 8 increase increase VB cord-010119-t1x9gknd 11252 9 the the DT cord-010119-t1x9gknd 11252 10 risk risk NN cord-010119-t1x9gknd 11252 11 of of IN cord-010119-t1x9gknd 11252 12 adverse adverse JJ cord-010119-t1x9gknd 11252 13 transfusion transfusion NN cord-010119-t1x9gknd 11252 14 reactions reaction NNS cord-010119-t1x9gknd 11252 15 . . . cord-010119-t1x9gknd 11253 1 Aims aim VBZ cord-010119-t1x9gknd 11253 2 : : : cord-010119-t1x9gknd 11254 1 Here here RB cord-010119-t1x9gknd 11254 2 we -PRON- PRP cord-010119-t1x9gknd 11254 3 evaluated evaluate VBD cord-010119-t1x9gknd 11254 4 the the DT cord-010119-t1x9gknd 11254 5 effectiveness effectiveness NN cord-010119-t1x9gknd 11254 6 of of IN cord-010119-t1x9gknd 11254 7 an an DT cord-010119-t1x9gknd 11254 8 innovative innovative JJ cord-010119-t1x9gknd 11254 9 acoustic acoustic NN cord-010119-t1x9gknd 11254 10 - - HYPH cord-010119-t1x9gknd 11254 11 based base VBN cord-010119-t1x9gknd 11254 12 fractionation fractionation NN cord-010119-t1x9gknd 11254 13 device device NN cord-010119-t1x9gknd 11254 14 by by IN cord-010119-t1x9gknd 11254 15 carrying carry VBG cord-010119-t1x9gknd 11254 16 out out RP cord-010119-t1x9gknd 11254 17 a a DT cord-010119-t1x9gknd 11254 18 qualitative qualitative JJ cord-010119-t1x9gknd 11254 19 and and CC cord-010119-t1x9gknd 11254 20 functional functional JJ cord-010119-t1x9gknd 11254 21 in in IN cord-010119-t1x9gknd 11254 22 vivo vivo NN cord-010119-t1x9gknd 11254 23 analysis analysis NN cord-010119-t1x9gknd 11254 24 of of IN cord-010119-t1x9gknd 11254 25 isolated isolate VBN cord-010119-t1x9gknd 11254 26 human human JJ cord-010119-t1x9gknd 11254 27 platelets platelet NNS cord-010119-t1x9gknd 11254 28 . . . cord-010119-t1x9gknd 11255 1 Study Study NNP cord-010119-t1x9gknd 11255 2 Design Design NNP cord-010119-t1x9gknd 11255 3 / / SYM cord-010119-t1x9gknd 11255 4 Method method NN cord-010119-t1x9gknd 11255 5 : : : cord-010119-t1x9gknd 11256 1 Whole whole JJ cord-010119-t1x9gknd 11256 2 blood blood NN cord-010119-t1x9gknd 11256 3 was be VBD cord-010119-t1x9gknd 11256 4 obtained obtain VBN cord-010119-t1x9gknd 11256 5 from from IN cord-010119-t1x9gknd 11256 6 14 14 CD cord-010119-t1x9gknd 11256 7 donors donor NNS cord-010119-t1x9gknd 11256 8 and and CC cord-010119-t1x9gknd 11256 9 fractionated fractionate VBN cord-010119-t1x9gknd 11256 10 using use VBG cord-010119-t1x9gknd 11256 11 an an DT cord-010119-t1x9gknd 11256 12 acoustic acoustic NN cord-010119-t1x9gknd 11256 13 - - HYPH cord-010119-t1x9gknd 11256 14 based base VBN cord-010119-t1x9gknd 11256 15 device device NN cord-010119-t1x9gknd 11256 16 . . . cord-010119-t1x9gknd 11257 1 Platelet platelet NN cord-010119-t1x9gknd 11257 2 recovery recovery NN cord-010119-t1x9gknd 11257 3 and and CC cord-010119-t1x9gknd 11257 4 purity purity NN cord-010119-t1x9gknd 11257 5 were be VBD cord-010119-t1x9gknd 11257 6 determined determine VBN cord-010119-t1x9gknd 11257 7 by by IN cord-010119-t1x9gknd 11257 8 quantifying quantify VBG cord-010119-t1x9gknd 11257 9 blood blood NN cord-010119-t1x9gknd 11257 10 cell cell NN cord-010119-t1x9gknd 11257 11 subpopulations subpopulation NNS cord-010119-t1x9gknd 11257 12 in in IN cord-010119-t1x9gknd 11257 13 the the DT cord-010119-t1x9gknd 11257 14 microchannel microchannel NN cord-010119-t1x9gknd 11257 15 outlet outlet NN cord-010119-t1x9gknd 11257 16 samples sample NNS cord-010119-t1x9gknd 11257 17 . . . cord-010119-t1x9gknd 11258 1 Quality quality NN cord-010119-t1x9gknd 11258 2 of of IN cord-010119-t1x9gknd 11258 3 isolated isolated JJ cord-010119-t1x9gknd 11258 4 platelets platelet NNS cord-010119-t1x9gknd 11258 5 was be VBD cord-010119-t1x9gknd 11258 6 evaluated evaluate VBN cord-010119-t1x9gknd 11258 7 using use VBG cord-010119-t1x9gknd 11258 8 the the DT cord-010119-t1x9gknd 11258 9 surface surface NN cord-010119-t1x9gknd 11258 10 expression expression NN cord-010119-t1x9gknd 11258 11 of of IN cord-010119-t1x9gknd 11258 12 two two CD cord-010119-t1x9gknd 11258 13 activation activation NN cord-010119-t1x9gknd 11258 14 markers marker NNS cord-010119-t1x9gknd 11258 15 ( ( -LRB- cord-010119-t1x9gknd 11258 16 P p NN cord-010119-t1x9gknd 11258 17 - - HYPH cord-010119-t1x9gknd 11258 18 selectin selectin NNP cord-010119-t1x9gknd 11258 19 , , , cord-010119-t1x9gknd 11258 20 PAC1 PAC1 NNP cord-010119-t1x9gknd 11258 21 ) ) -RRB- cord-010119-t1x9gknd 11258 22 using use VBG cord-010119-t1x9gknd 11258 23 flow flow NN cord-010119-t1x9gknd 11258 24 cytometric cytometric JJ cord-010119-t1x9gknd 11258 25 methods method NNS cord-010119-t1x9gknd 11258 26 while while IN cord-010119-t1x9gknd 11258 27 their -PRON- PRP$ cord-010119-t1x9gknd 11258 28 procoagulant procoagulant NN cord-010119-t1x9gknd 11258 29 ability ability NN cord-010119-t1x9gknd 11258 30 was be VBD cord-010119-t1x9gknd 11258 31 investigated investigate VBN cord-010119-t1x9gknd 11258 32 using use VBG cord-010119-t1x9gknd 11258 33 in in IN cord-010119-t1x9gknd 11258 34 vivo vivo NN cord-010119-t1x9gknd 11258 35 experimentation experimentation NN cord-010119-t1x9gknd 11258 36 . . . cord-010119-t1x9gknd 11259 1 Platelets platelet NNS cord-010119-t1x9gknd 11259 2 isolated isolate VBN cord-010119-t1x9gknd 11259 3 using use VBG cord-010119-t1x9gknd 11259 4 a a DT cord-010119-t1x9gknd 11259 5 soft soft JJ cord-010119-t1x9gknd 11259 6 - - HYPH cord-010119-t1x9gknd 11259 7 spin spin NN cord-010119-t1x9gknd 11259 8 protocol protocol NN cord-010119-t1x9gknd 11259 9 , , , cord-010119-t1x9gknd 11259 10 were be VBD cord-010119-t1x9gknd 11259 11 used use VBN cord-010119-t1x9gknd 11259 12 as as IN cord-010119-t1x9gknd 11259 13 inactivated inactivate VBN cord-010119-t1x9gknd 11259 14 control control NN cord-010119-t1x9gknd 11259 15 . . . cord-010119-t1x9gknd 11260 1 Results/ Results/ . cord-010119-t1x9gknd 11261 1 Finding finding NN cord-010119-t1x9gknd 11261 2 : : : cord-010119-t1x9gknd 11261 3 Fractionation fractionation NN cord-010119-t1x9gknd 11261 4 using use VBG cord-010119-t1x9gknd 11261 5 the the DT cord-010119-t1x9gknd 11261 6 acoustic acoustic NN cord-010119-t1x9gknd 11261 7 - - HYPH cord-010119-t1x9gknd 11261 8 based base VBN cord-010119-t1x9gknd 11261 9 device device NN cord-010119-t1x9gknd 11261 10 led lead VBD cord-010119-t1x9gknd 11261 11 to to IN cord-010119-t1x9gknd 11261 12 a a DT cord-010119-t1x9gknd 11261 13 red red JJ cord-010119-t1x9gknd 11261 14 blood blood NN cord-010119-t1x9gknd 11261 15 cell cell NN cord-010119-t1x9gknd 11261 16 clearance clearance NN cord-010119-t1x9gknd 11261 17 ratio ratio NN cord-010119-t1x9gknd 11261 18 from from IN cord-010119-t1x9gknd 11261 19 whole whole JJ cord-010119-t1x9gknd 11261 20 blood blood NN cord-010119-t1x9gknd 11261 21 greater great JJR cord-010119-t1x9gknd 11261 22 than than IN cord-010119-t1x9gknd 11261 23 80 80 CD cord-010119-t1x9gknd 11261 24 % % NN cord-010119-t1x9gknd 11261 25 ( ( -LRB- cord-010119-t1x9gknd 11261 26 p p NN cord-010119-t1x9gknd 11261 27 < < XX cord-010119-t1x9gknd 11261 28 0.001 0.001 CD cord-010119-t1x9gknd 11261 29 ) ) -RRB- cord-010119-t1x9gknd 11261 30 and and CC cord-010119-t1x9gknd 11261 31 a a DT cord-010119-t1x9gknd 11261 32 purity purity NN cord-010119-t1x9gknd 11261 33 of of IN cord-010119-t1x9gknd 11261 34 platelets platelet NNS cord-010119-t1x9gknd 11261 35 close close JJ cord-010119-t1x9gknd 11261 36 to to IN cord-010119-t1x9gknd 11261 37 91.0 91.0 CD cord-010119-t1x9gknd 11261 38 % % NN cord-010119-t1x9gknd 11261 39 . . . cord-010119-t1x9gknd 11262 1 We -PRON- PRP cord-010119-t1x9gknd 11262 2 did do VBD cord-010119-t1x9gknd 11262 3 not not RB cord-010119-t1x9gknd 11262 4 find find VB cord-010119-t1x9gknd 11262 5 any any DT cord-010119-t1x9gknd 11262 6 difference difference NN cord-010119-t1x9gknd 11262 7 in in IN cord-010119-t1x9gknd 11262 8 terms term NNS cord-010119-t1x9gknd 11262 9 of of IN cord-010119-t1x9gknd 11262 10 quality quality NN cord-010119-t1x9gknd 11262 11 and and CC cord-010119-t1x9gknd 11262 12 functionality functionality NN cord-010119-t1x9gknd 11262 13 of of IN cord-010119-t1x9gknd 11262 14 platelets platelet NNS cord-010119-t1x9gknd 11262 15 from from IN cord-010119-t1x9gknd 11262 16 the the DT cord-010119-t1x9gknd 11262 17 same same JJ cord-010119-t1x9gknd 11262 18 donors donor NNS cord-010119-t1x9gknd 11262 19 isolated isolate VBN cord-010119-t1x9gknd 11262 20 using use VBG cord-010119-t1x9gknd 11262 21 the the DT cord-010119-t1x9gknd 11262 22 acoustic acoustic JJ cord-010119-t1x9gknd 11262 23 device device NN cord-010119-t1x9gknd 11262 24 versus versus IN cord-010119-t1x9gknd 11262 25 the the DT cord-010119-t1x9gknd 11262 26 soft soft JJ cord-010119-t1x9gknd 11262 27 - - HYPH cord-010119-t1x9gknd 11262 28 spin spin NN cord-010119-t1x9gknd 11262 29 protocol protocol NN cord-010119-t1x9gknd 11262 30 . . . cord-010119-t1x9gknd 11263 1 Conclusion conclusion NN cord-010119-t1x9gknd 11263 2 : : : cord-010119-t1x9gknd 11264 1 This this DT cord-010119-t1x9gknd 11264 2 acoustic acoustic NN cord-010119-t1x9gknd 11264 3 - - HYPH cord-010119-t1x9gknd 11264 4 based base VBN cord-010119-t1x9gknd 11264 5 blood blood NN cord-010119-t1x9gknd 11264 6 processing processing NN cord-010119-t1x9gknd 11264 7 method method NN cord-010119-t1x9gknd 11264 8 led lead VBN cord-010119-t1x9gknd 11264 9 to to IN cord-010119-t1x9gknd 11264 10 excellent excellent JJ cord-010119-t1x9gknd 11264 11 preservation preservation NN cord-010119-t1x9gknd 11264 12 of of IN cord-010119-t1x9gknd 11264 13 platelet platelet NN cord-010119-t1x9gknd 11264 14 quality quality NN cord-010119-t1x9gknd 11264 15 and and CC cord-010119-t1x9gknd 11264 16 functionality functionality NN cord-010119-t1x9gknd 11264 17 providing provide VBG cord-010119-t1x9gknd 11264 18 a a DT cord-010119-t1x9gknd 11264 19 novel novel JJ cord-010119-t1x9gknd 11264 20 promising promising JJ cord-010119-t1x9gknd 11264 21 technique technique NN cord-010119-t1x9gknd 11264 22 for for IN cord-010119-t1x9gknd 11264 23 whole whole JJ cord-010119-t1x9gknd 11264 24 blood blood NN cord-010119-t1x9gknd 11264 25 fractionation fractionation NN cord-010119-t1x9gknd 11264 26 in in IN cord-010119-t1x9gknd 11264 27 clinical clinical JJ cord-010119-t1x9gknd 11264 28 settings setting NNS cord-010119-t1x9gknd 11264 29 . . . cord-010119-t1x9gknd 11265 1 Automation automation NN cord-010119-t1x9gknd 11265 2 in in IN cord-010119-t1x9gknd 11265 3 Blood Blood NNP cord-010119-t1x9gknd 11265 4 Bank Bank NNP cord-010119-t1x9gknd 11265 5 Processing processing NN cord-010119-t1x9gknd 11265 6 : : : cord-010119-t1x9gknd 11266 1 Where where WRB cord-010119-t1x9gknd 11266 2 We -PRON- PRP cord-010119-t1x9gknd 11266 3 Go go VB cord-010119-t1x9gknd 11266 4 ? ? . cord-010119-t1x9gknd 11267 1 Robert Robert NNP cord-010119-t1x9gknd 11267 2 Fernandez Fernandez NNP cord-010119-t1x9gknd 11267 3 , , , cord-010119-t1x9gknd 11267 4 Lluis Lluis NNP cord-010119-t1x9gknd 11267 5 Puig Puig NNP cord-010119-t1x9gknd 11267 6 , , , cord-010119-t1x9gknd 11267 7 Pilar Pilar NNP cord-010119-t1x9gknd 11267 8 Ortiz Ortiz NNP cord-010119-t1x9gknd 11267 9 , , , cord-010119-t1x9gknd 11267 10 Joan Joan NNP cord-010119-t1x9gknd 11267 11 Ovejo Ovejo NNP cord-010119-t1x9gknd 11267 12 , , , cord-010119-t1x9gknd 11267 13 Nuria Nuria NNP cord-010119-t1x9gknd 11267 14 Martinez Martinez NNP cord-010119-t1x9gknd 11267 15 , , , cord-010119-t1x9gknd 11267 16 Elena Elena NNP cord-010119-t1x9gknd 11267 17 Valdivia Valdivia NNP cord-010119-t1x9gknd 11267 18 and and CC cord-010119-t1x9gknd 11267 19 Susana Susana NNP cord-010119-t1x9gknd 11267 20 G G NNP cord-010119-t1x9gknd 11267 21 Gomez Gomez NNP cord-010119-t1x9gknd 11268 1 * * NFP cord-010119-t1x9gknd 11268 2 . . . cord-010119-t1x9gknd 11269 1 Banc Banc NNP cord-010119-t1x9gknd 11269 2 de de NNP cord-010119-t1x9gknd 11269 3 Sang Sang NNP cord-010119-t1x9gknd 11270 1 i i PRP cord-010119-t1x9gknd 11271 1 Teixits Teixits NNP cord-010119-t1x9gknd 11271 2 Background Background NNP cord-010119-t1x9gknd 11271 3 / / SYM cord-010119-t1x9gknd 11271 4 Case Case NNP cord-010119-t1x9gknd 11271 5 Studies Studies NNPS cord-010119-t1x9gknd 11271 6 : : : cord-010119-t1x9gknd 11271 7 Nowadays nowadays RB cord-010119-t1x9gknd 11271 8 , , , cord-010119-t1x9gknd 11271 9 blood blood NN cord-010119-t1x9gknd 11271 10 banking banking NN cord-010119-t1x9gknd 11271 11 is be VBZ cord-010119-t1x9gknd 11271 12 requiring require VBG cord-010119-t1x9gknd 11271 13 new new JJ cord-010119-t1x9gknd 11271 14 strategies strategy NNS cord-010119-t1x9gknd 11271 15 to to TO cord-010119-t1x9gknd 11271 16 manufacture manufacture VB cord-010119-t1x9gknd 11271 17 blood blood NN cord-010119-t1x9gknd 11271 18 components component NNS cord-010119-t1x9gknd 11271 19 , , , cord-010119-t1x9gknd 11271 20 due due IN cord-010119-t1x9gknd 11271 21 to to IN cord-010119-t1x9gknd 11271 22 the the DT cord-010119-t1x9gknd 11271 23 increase increase NN cord-010119-t1x9gknd 11271 24 on on IN cord-010119-t1x9gknd 11271 25 their -PRON- PRP$ cord-010119-t1x9gknd 11271 26 production production NN cord-010119-t1x9gknd 11271 27 . . . cord-010119-t1x9gknd 11272 1 At at IN cord-010119-t1x9gknd 11272 2 Banc Banc NNP cord-010119-t1x9gknd 11272 3 de de NNP cord-010119-t1x9gknd 11272 4 Sang Sang NNP cord-010119-t1x9gknd 11272 5 I I NNP cord-010119-t1x9gknd 11272 6 Teixits Teixits NNP cord-010119-t1x9gknd 11272 7 ( ( -LRB- cord-010119-t1x9gknd 11272 8 BST BST NNP cord-010119-t1x9gknd 11272 9 ) ) -RRB- cord-010119-t1x9gknd 11272 10 , , , cord-010119-t1x9gknd 11272 11 we -PRON- PRP cord-010119-t1x9gknd 11272 12 have have VBP cord-010119-t1x9gknd 11272 13 implemented implement VBN cord-010119-t1x9gknd 11272 14 during during IN cord-010119-t1x9gknd 11272 15 the the DT cord-010119-t1x9gknd 11272 16 last last JJ cord-010119-t1x9gknd 11272 17 years year NNS cord-010119-t1x9gknd 11272 18 automation automation NN cord-010119-t1x9gknd 11272 19 manufacturing manufacturing NN cord-010119-t1x9gknd 11272 20 , , , cord-010119-t1x9gknd 11272 21 including include VBG cord-010119-t1x9gknd 11272 22 lean lean JJ cord-010119-t1x9gknd 11272 23 management management NN cord-010119-t1x9gknd 11272 24 methods method NNS cord-010119-t1x9gknd 11272 25 , , , cord-010119-t1x9gknd 11272 26 to to TO cord-010119-t1x9gknd 11272 27 be be VB cord-010119-t1x9gknd 11272 28 able able JJ cord-010119-t1x9gknd 11272 29 to to TO cord-010119-t1x9gknd 11272 30 process process VB cord-010119-t1x9gknd 11272 31 our -PRON- PRP$ cord-010119-t1x9gknd 11272 32 needs need NNS cord-010119-t1x9gknd 11272 33 of of IN cord-010119-t1x9gknd 11272 34 over over IN cord-010119-t1x9gknd 11272 35 250.000 250.000 CD cord-010119-t1x9gknd 11272 36 blood blood NN cord-010119-t1x9gknd 11272 37 donations donation NNS cord-010119-t1x9gknd 11272 38 for for IN cord-010119-t1x9gknd 11272 39 an an DT cord-010119-t1x9gknd 11272 40 area area NN cord-010119-t1x9gknd 11272 41 with with IN cord-010119-t1x9gknd 11272 42 more more JJR cord-010119-t1x9gknd 11272 43 than than IN cord-010119-t1x9gknd 11272 44 7 7 CD cord-010119-t1x9gknd 11272 45 million million CD cord-010119-t1x9gknd 11272 46 people people NNS cord-010119-t1x9gknd 11272 47 . . . cord-010119-t1x9gknd 11273 1 Study Study NNP cord-010119-t1x9gknd 11273 2 Design Design NNP cord-010119-t1x9gknd 11273 3 / / SYM cord-010119-t1x9gknd 11273 4 Method method NN cord-010119-t1x9gknd 11273 5 : : : cord-010119-t1x9gknd 11274 1 The the DT cord-010119-t1x9gknd 11274 2 automation automation NN cord-010119-t1x9gknd 11274 3 of of IN cord-010119-t1x9gknd 11274 4 blood blood NN cord-010119-t1x9gknd 11274 5 donations donation NNS cord-010119-t1x9gknd 11274 6 process process NN cord-010119-t1x9gknd 11274 7 , , , cord-010119-t1x9gknd 11274 8 BST BST NNP cord-010119-t1x9gknd 11274 9 has have VBZ cord-010119-t1x9gknd 11274 10 done do VBN cord-010119-t1x9gknd 11274 11 different different JJ cord-010119-t1x9gknd 11274 12 changes change NNS cord-010119-t1x9gknd 11274 13 on on IN cord-010119-t1x9gknd 11274 14 the the DT cord-010119-t1x9gknd 11274 15 equipment equipment NN cord-010119-t1x9gknd 11274 16 . . . cord-010119-t1x9gknd 11275 1 In in IN cord-010119-t1x9gknd 11275 2 2005 2005 CD cord-010119-t1x9gknd 11275 3 , , , cord-010119-t1x9gknd 11275 4 Orbisac Orbisac NNP cord-010119-t1x9gknd 11275 5 ( ( -LRB- cord-010119-t1x9gknd 11275 6 Terumo Terumo NNP cord-010119-t1x9gknd 11275 7 BCT BCT NNP cord-010119-t1x9gknd 11275 8 ) ) -RRB- cord-010119-t1x9gknd 11275 9 was be VBD cord-010119-t1x9gknd 11275 10 the the DT cord-010119-t1x9gknd 11275 11 equipment equipment NN cord-010119-t1x9gknd 11275 12 to to TO cord-010119-t1x9gknd 11275 13 obtain obtain VB cord-010119-t1x9gknd 11275 14 buffy buffy NNP cord-010119-t1x9gknd 11275 15 coats coat NNS cord-010119-t1x9gknd 11275 16 and and CC cord-010119-t1x9gknd 11275 17 from from IN cord-010119-t1x9gknd 11275 18 this this DT cord-010119-t1x9gknd 11275 19 product product NN cord-010119-t1x9gknd 11275 20 , , , cord-010119-t1x9gknd 11275 21 we -PRON- PRP cord-010119-t1x9gknd 11275 22 got get VBD cord-010119-t1x9gknd 11275 23 platelets platelet NNS cord-010119-t1x9gknd 11275 24 concentrates concentrate VBZ cord-010119-t1x9gknd 11275 25 . . . cord-010119-t1x9gknd 11276 1 It -PRON- PRP cord-010119-t1x9gknd 11276 2 was be VBD cord-010119-t1x9gknd 11276 3 in in IN cord-010119-t1x9gknd 11276 4 2007 2007 CD cord-010119-t1x9gknd 11276 5 , , , cord-010119-t1x9gknd 11276 6 when when WRB cord-010119-t1x9gknd 11276 7 we -PRON- PRP cord-010119-t1x9gknd 11276 8 moved move VBD cord-010119-t1x9gknd 11276 9 from from IN cord-010119-t1x9gknd 11276 10 this this DT cord-010119-t1x9gknd 11276 11 equipment equipment NN cord-010119-t1x9gknd 11276 12 to to IN cord-010119-t1x9gknd 11276 13 Atreus Atreus NNP cord-010119-t1x9gknd 11276 14 2C 2c NN cord-010119-t1x9gknd 11276 15 ( ( -LRB- cord-010119-t1x9gknd 11276 16 Terumo Terumo NNP cord-010119-t1x9gknd 11276 17 BCT BCT NNP cord-010119-t1x9gknd 11276 18 ) ) -RRB- cord-010119-t1x9gknd 11276 19 , , , cord-010119-t1x9gknd 11276 20 to to TO cord-010119-t1x9gknd 11276 21 get get VB cord-010119-t1x9gknd 11276 22 red red JJ cord-010119-t1x9gknd 11276 23 blood blood NN cord-010119-t1x9gknd 11276 24 cells cell NNS cord-010119-t1x9gknd 11276 25 , , , cord-010119-t1x9gknd 11276 26 buffy buffy NNP cord-010119-t1x9gknd 11276 27 coat coat NNP cord-010119-t1x9gknd 11276 28 and and CC cord-010119-t1x9gknd 11276 29 fresh fresh JJ cord-010119-t1x9gknd 11276 30 frozen frozen JJ cord-010119-t1x9gknd 11276 31 plasma plasma NN cord-010119-t1x9gknd 11276 32 . . . cord-010119-t1x9gknd 11277 1 Then then RB cord-010119-t1x9gknd 11277 2 we -PRON- PRP cord-010119-t1x9gknd 11277 3 did do VBD cord-010119-t1x9gknd 11277 4 some some DT cord-010119-t1x9gknd 11277 5 updated update VBN cord-010119-t1x9gknd 11277 6 on on IN cord-010119-t1x9gknd 11277 7 Atreus Atreus NNP cord-010119-t1x9gknd 11277 8 ; ; : cord-010119-t1x9gknd 11277 9 in in IN cord-010119-t1x9gknd 11277 10 2011 2011 CD cord-010119-t1x9gknd 11277 11 we -PRON- PRP cord-010119-t1x9gknd 11277 12 changed change VBD cord-010119-t1x9gknd 11277 13 to to IN cord-010119-t1x9gknd 11277 14 Atreus Atreus NNP cord-010119-t1x9gknd 11277 15 3C 3c NN cord-010119-t1x9gknd 11277 16 ( ( -LRB- cord-010119-t1x9gknd 11277 17 Terumo Terumo NNP cord-010119-t1x9gknd 11277 18 BCT BCT NNP cord-010119-t1x9gknd 11277 19 ) ) -RRB- cord-010119-t1x9gknd 11277 20 and and CC cord-010119-t1x9gknd 11277 21 finally finally RB cord-010119-t1x9gknd 11277 22 in in IN cord-010119-t1x9gknd 11277 23 2013 2013 CD cord-010119-t1x9gknd 11277 24 , , , cord-010119-t1x9gknd 11277 25 we -PRON- PRP cord-010119-t1x9gknd 11277 26 moved move VBD cord-010119-t1x9gknd 11277 27 to to IN cord-010119-t1x9gknd 11277 28 Reveos Reveos NNP cord-010119-t1x9gknd 11277 29 system system NN cord-010119-t1x9gknd 11277 30 ( ( -LRB- cord-010119-t1x9gknd 11277 31 Terumo Terumo NNP cord-010119-t1x9gknd 11277 32 BCT BCT NNP cord-010119-t1x9gknd 11277 33 ) ) -RRB- cord-010119-t1x9gknd 11277 34 . . . cord-010119-t1x9gknd 11278 1 Since since IN cord-010119-t1x9gknd 11278 2 the the DT cord-010119-t1x9gknd 11278 3 changes change NNS cord-010119-t1x9gknd 11278 4 in in IN cord-010119-t1x9gknd 11278 5 2007 2007 CD cord-010119-t1x9gknd 11278 6 , , , cord-010119-t1x9gknd 11278 7 our -PRON- PRP$ cord-010119-t1x9gknd 11278 8 blood blood NN cord-010119-t1x9gknd 11278 9 components component NNS cord-010119-t1x9gknd 11278 10 were be VBD cord-010119-t1x9gknd 11278 11 red red JJ cord-010119-t1x9gknd 11278 12 cell cell NN cord-010119-t1x9gknd 11278 13 concentrate concentrate NN cord-010119-t1x9gknd 11278 14 , , , cord-010119-t1x9gknd 11278 15 plasma plasma NN cord-010119-t1x9gknd 11278 16 , , , cord-010119-t1x9gknd 11278 17 platelets platelet NNS cord-010119-t1x9gknd 11278 18 and and CC cord-010119-t1x9gknd 11278 19 a a DT cord-010119-t1x9gknd 11278 20 leukocyte leukocyte NN cord-010119-t1x9gknd 11278 21 residue residue NN cord-010119-t1x9gknd 11278 22 . . . cord-010119-t1x9gknd 11279 1 While while IN cord-010119-t1x9gknd 11279 2 all all PDT cord-010119-t1x9gknd 11279 3 these these DT cord-010119-t1x9gknd 11279 4 changes change NNS cord-010119-t1x9gknd 11279 5 in in IN cord-010119-t1x9gknd 11279 6 processing processing NN cord-010119-t1x9gknd 11279 7 equipment equipment NN cord-010119-t1x9gknd 11279 8 , , , cord-010119-t1x9gknd 11279 9 we -PRON- PRP cord-010119-t1x9gknd 11279 10 added add VBD cord-010119-t1x9gknd 11279 11 also also RB cord-010119-t1x9gknd 11279 12 some some DT cord-010119-t1x9gknd 11279 13 automation automation NN cord-010119-t1x9gknd 11279 14 in in IN cord-010119-t1x9gknd 11279 15 our -PRON- PRP$ cord-010119-t1x9gknd 11279 16 registration registration NN cord-010119-t1x9gknd 11279 17 ( ( -LRB- cord-010119-t1x9gknd 11279 18 donation donation NN cord-010119-t1x9gknd 11279 19 ID ID NNP cord-010119-t1x9gknd 11279 20 , , , cord-010119-t1x9gknd 11279 21 weight weight NN cord-010119-t1x9gknd 11279 22 and and CC cord-010119-t1x9gknd 11279 23 temperature temperature NN cord-010119-t1x9gknd 11279 24 ) ) -RRB- cord-010119-t1x9gknd 11279 25 and and CC cord-010119-t1x9gknd 11279 26 labeling labeling NN cord-010119-t1x9gknd 11279 27 steps step NNS cord-010119-t1x9gknd 11279 28 , , , cord-010119-t1x9gknd 11279 29 implementing implement VBG cord-010119-t1x9gknd 11279 30 two two CD cord-010119-t1x9gknd 11279 31 homemade homemade JJ cord-010119-t1x9gknd 11279 32 robots robot NNS cord-010119-t1x9gknd 11279 33 . . . cord-010119-t1x9gknd 11280 1 And and CC cord-010119-t1x9gknd 11280 2 finally finally RB cord-010119-t1x9gknd 11280 3 , , , cord-010119-t1x9gknd 11280 4 to to TO cord-010119-t1x9gknd 11280 5 get get VB cord-010119-t1x9gknd 11280 6 better well JJR cord-010119-t1x9gknd 11280 7 results result NNS cord-010119-t1x9gknd 11280 8 and and CC cord-010119-t1x9gknd 11280 9 more more JJR cord-010119-t1x9gknd 11280 10 efficacy efficacy NN cord-010119-t1x9gknd 11280 11 in in IN cord-010119-t1x9gknd 11280 12 our -PRON- PRP$ cord-010119-t1x9gknd 11280 13 production production NN cord-010119-t1x9gknd 11280 14 , , , cord-010119-t1x9gknd 11280 15 in in IN cord-010119-t1x9gknd 11280 16 2009 2009 CD cord-010119-t1x9gknd 11280 17 , , , cord-010119-t1x9gknd 11280 18 BST BST NNP cord-010119-t1x9gknd 11280 19 incorporated incorporate VBD cord-010119-t1x9gknd 11280 20 an an DT cord-010119-t1x9gknd 11280 21 engineer engineer NN cord-010119-t1x9gknd 11280 22 to to TO cord-010119-t1x9gknd 11280 23 introduce introduce VB cord-010119-t1x9gknd 11280 24 lean lean JJ cord-010119-t1x9gknd 11280 25 manufacturing manufacturing NN cord-010119-t1x9gknd 11280 26 methods method NNS cord-010119-t1x9gknd 11280 27 . . . cord-010119-t1x9gknd 11281 1 These these DT cord-010119-t1x9gknd 11281 2 methods method NNS cord-010119-t1x9gknd 11281 3 are be VBP cord-010119-t1x9gknd 11281 4 based base VBN cord-010119-t1x9gknd 11281 5 on on IN cord-010119-t1x9gknd 11281 6 the the DT cord-010119-t1x9gknd 11281 7 identification identification NN cord-010119-t1x9gknd 11281 8 and and CC cord-010119-t1x9gknd 11281 9 analysis analysis NN cord-010119-t1x9gknd 11281 10 of of IN cord-010119-t1x9gknd 11281 11 problems problem NNS cord-010119-t1x9gknd 11281 12 , , , cord-010119-t1x9gknd 11281 13 and and CC cord-010119-t1x9gknd 11281 14 then then RB cord-010119-t1x9gknd 11281 15 chose choose VBD cord-010119-t1x9gknd 11281 16 all all PDT cord-010119-t1x9gknd 11281 17 these these DT cord-010119-t1x9gknd 11281 18 activates activate NNS cord-010119-t1x9gknd 11281 19 that that WDT cord-010119-t1x9gknd 11281 20 add add VBP cord-010119-t1x9gknd 11281 21 some some DT cord-010119-t1x9gknd 11281 22 value value NN cord-010119-t1x9gknd 11281 23 to to IN cord-010119-t1x9gknd 11281 24 the the DT cord-010119-t1x9gknd 11281 25 procedure procedure NN cord-010119-t1x9gknd 11281 26 . . . cord-010119-t1x9gknd 11282 1 Results/ Results/ . cord-010119-t1x9gknd 11283 1 Finding find VBG cord-010119-t1x9gknd 11283 2 : : : cord-010119-t1x9gknd 11283 3 Once once IN cord-010119-t1x9gknd 11283 4 all all PDT cord-010119-t1x9gknd 11283 5 these these DT cord-010119-t1x9gknd 11283 6 changes change NNS cord-010119-t1x9gknd 11283 7 have have VBP cord-010119-t1x9gknd 11283 8 been be VBN cord-010119-t1x9gknd 11283 9 updated update VBN cord-010119-t1x9gknd 11283 10 , , , cord-010119-t1x9gknd 11283 11 we -PRON- PRP cord-010119-t1x9gknd 11283 12 have have VBP cord-010119-t1x9gknd 11283 13 evaluated evaluate VBN cord-010119-t1x9gknd 11283 14 the the DT cord-010119-t1x9gknd 11283 15 quality quality NN cord-010119-t1x9gknd 11283 16 of of IN cord-010119-t1x9gknd 11283 17 blood blood NN cord-010119-t1x9gknd 11283 18 components component NNS cord-010119-t1x9gknd 11283 19 , , , cord-010119-t1x9gknd 11283 20 such such JJ cord-010119-t1x9gknd 11283 21 as as IN cord-010119-t1x9gknd 11283 22 red red JJ cord-010119-t1x9gknd 11283 23 cells cell NNS cord-010119-t1x9gknd 11283 24 and and CC cord-010119-t1x9gknd 11283 25 platelets platelet NNS cord-010119-t1x9gknd 11283 26 , , , cord-010119-t1x9gknd 11283 27 also also RB cord-010119-t1x9gknd 11283 28 the the DT cord-010119-t1x9gknd 11283 29 number number NN cord-010119-t1x9gknd 11283 30 of of IN cord-010119-t1x9gknd 11283 31 donations donation NNS cord-010119-t1x9gknd 11283 32 that that WDT cord-010119-t1x9gknd 11283 33 we -PRON- PRP cord-010119-t1x9gknd 11283 34 were be VBD cord-010119-t1x9gknd 11283 35 missing miss VBG cord-010119-t1x9gknd 11283 36 and and CC cord-010119-t1x9gknd 11283 37 working work VBG cord-010119-t1x9gknd 11283 38 hours hour NNS cord-010119-t1x9gknd 11283 39 that that WDT cord-010119-t1x9gknd 11283 40 were be VBD cord-010119-t1x9gknd 11283 41 necessary necessary JJ cord-010119-t1x9gknd 11283 42 to to TO cord-010119-t1x9gknd 11283 43 process process VB cord-010119-t1x9gknd 11283 44 our -PRON- PRP$ cord-010119-t1x9gknd 11283 45 blood blood NN cord-010119-t1x9gknd 11283 46 donations donation NNS cord-010119-t1x9gknd 11283 47 . . . cord-010119-t1x9gknd 11284 1 This this DT cord-010119-t1x9gknd 11284 2 evaluation evaluation NN cord-010119-t1x9gknd 11284 3 was be VBD cord-010119-t1x9gknd 11284 4 done do VBN cord-010119-t1x9gknd 11284 5 for for IN cord-010119-t1x9gknd 11284 6 processes process NNS cord-010119-t1x9gknd 11284 7 during during IN cord-010119-t1x9gknd 11284 8 2008 2008 CD cord-010119-t1x9gknd 11284 9 and and CC cord-010119-t1x9gknd 11284 10 2016 2016 CD cord-010119-t1x9gknd 11284 11 . . . cord-010119-t1x9gknd 11285 1 Conclusion conclusion NN cord-010119-t1x9gknd 11285 2 : : : cord-010119-t1x9gknd 11285 3 With with IN cord-010119-t1x9gknd 11285 4 these these DT cord-010119-t1x9gknd 11285 5 results result NNS cord-010119-t1x9gknd 11285 6 , , , cord-010119-t1x9gknd 11285 7 it -PRON- PRP cord-010119-t1x9gknd 11285 8 's be VBZ cord-010119-t1x9gknd 11285 9 obvious obvious JJ cord-010119-t1x9gknd 11285 10 that that IN cord-010119-t1x9gknd 11285 11 automation automation NN cord-010119-t1x9gknd 11285 12 in in IN cord-010119-t1x9gknd 11285 13 blood blood NN cord-010119-t1x9gknd 11285 14 banking banking NN cord-010119-t1x9gknd 11285 15 makes make VBZ cord-010119-t1x9gknd 11285 16 more more RBR cord-010119-t1x9gknd 11285 17 efficient efficient JJ cord-010119-t1x9gknd 11285 18 the the DT cord-010119-t1x9gknd 11285 19 manufacturing manufacturing NN cord-010119-t1x9gknd 11285 20 of of IN cord-010119-t1x9gknd 11285 21 blood blood NN cord-010119-t1x9gknd 11285 22 components component NNS cord-010119-t1x9gknd 11285 23 , , , cord-010119-t1x9gknd 11285 24 getting get VBG cord-010119-t1x9gknd 11285 25 better well JJR cord-010119-t1x9gknd 11285 26 quality quality NN cord-010119-t1x9gknd 11285 27 of of IN cord-010119-t1x9gknd 11285 28 them -PRON- PRP cord-010119-t1x9gknd 11285 29 and and CC cord-010119-t1x9gknd 11285 30 also also RB cord-010119-t1x9gknd 11285 31 in in IN cord-010119-t1x9gknd 11285 32 a a DT cord-010119-t1x9gknd 11285 33 cheaper cheap JJR cord-010119-t1x9gknd 11285 34 way way NN cord-010119-t1x9gknd 11285 35 . . . cord-010119-t1x9gknd 11286 1 We -PRON- PRP cord-010119-t1x9gknd 11286 2 encourage encourage VBP cord-010119-t1x9gknd 11286 3 maintaining maintain VBG cord-010119-t1x9gknd 11286 4 lean lean JJ cord-010119-t1x9gknd 11286 5 philosophy philosophy NN cord-010119-t1x9gknd 11286 6 in in IN cord-010119-t1x9gknd 11286 7 order order NN cord-010119-t1x9gknd 11286 8 to to TO cord-010119-t1x9gknd 11286 9 keep keep VB cord-010119-t1x9gknd 11286 10 improving improve VBG cord-010119-t1x9gknd 11286 11 our -PRON- PRP$ cord-010119-t1x9gknd 11286 12 methods method NNS cord-010119-t1x9gknd 11286 13 and and CC cord-010119-t1x9gknd 11286 14 identifying identify VBG cord-010119-t1x9gknd 11286 15 those those DT cord-010119-t1x9gknd 11286 16 activities activity NNS cord-010119-t1x9gknd 11286 17 that that WDT cord-010119-t1x9gknd 11286 18 add add VBP cord-010119-t1x9gknd 11286 19 value value NN cord-010119-t1x9gknd 11286 20 to to IN cord-010119-t1x9gknd 11286 21 our -PRON- PRP$ cord-010119-t1x9gknd 11286 22 processes process NNS cord-010119-t1x9gknd 11286 23 and and CC cord-010119-t1x9gknd 11286 24 get get VB cord-010119-t1x9gknd 11286 25 rid rid VBN cord-010119-t1x9gknd 11286 26 of of IN cord-010119-t1x9gknd 11286 27 those those DT cord-010119-t1x9gknd 11286 28 ones one NNS cord-010119-t1x9gknd 11286 29 that that WDT cord-010119-t1x9gknd 11286 30 are be VBP cord-010119-t1x9gknd 11286 31 not not RB cord-010119-t1x9gknd 11286 32 necessary necessary JJ cord-010119-t1x9gknd 11286 33 . . . cord-010119-t1x9gknd 11287 1 In in IN cord-010119-t1x9gknd 11287 2 a a DT cord-010119-t1x9gknd 11287 3 globalized globalized JJ cord-010119-t1x9gknd 11287 4 and and CC cord-010119-t1x9gknd 11287 5 industrialized industrialized JJ cord-010119-t1x9gknd 11287 6 world world NN cord-010119-t1x9gknd 11287 7 , , , cord-010119-t1x9gknd 11287 8 where where WRB cord-010119-t1x9gknd 11287 9 everything everything NN cord-010119-t1x9gknd 11287 10 changes change VBZ cord-010119-t1x9gknd 11287 11 very very RB cord-010119-t1x9gknd 11287 12 fast fast RB cord-010119-t1x9gknd 11287 13 , , , cord-010119-t1x9gknd 11287 14 these these DT cord-010119-t1x9gknd 11287 15 improvements improvement NNS cord-010119-t1x9gknd 11287 16 are be VBP cord-010119-t1x9gknd 11287 17 necessary necessary JJ cord-010119-t1x9gknd 11287 18 to to TO cord-010119-t1x9gknd 11287 19 be be VB cord-010119-t1x9gknd 11287 20 on on IN cord-010119-t1x9gknd 11287 21 top top NN cord-010119-t1x9gknd 11287 22 of of IN cord-010119-t1x9gknd 11287 23 the the DT cord-010119-t1x9gknd 11287 24 field field NN cord-010119-t1x9gknd 11287 25 and and CC cord-010119-t1x9gknd 11287 26 be be VB cord-010119-t1x9gknd 11287 27 a a DT cord-010119-t1x9gknd 11287 28 state state NN cord-010119-t1x9gknd 11287 29 of of IN cord-010119-t1x9gknd 11287 30 the the DT cord-010119-t1x9gknd 11287 31 art art NN cord-010119-t1x9gknd 11287 32 blood blood NN cord-010119-t1x9gknd 11287 33 bank bank NN cord-010119-t1x9gknd 11287 34 . . . cord-010119-t1x9gknd 11288 1 Background Background NNP cord-010119-t1x9gknd 11288 2 / / SYM cord-010119-t1x9gknd 11288 3 Case Case NNP cord-010119-t1x9gknd 11288 4 Studies Studies NNPS cord-010119-t1x9gknd 11289 1 : : : cord-010119-t1x9gknd 11289 2 The the DT cord-010119-t1x9gknd 11289 3 laboratory laboratory NN cord-010119-t1x9gknd 11289 4 envisioned envision VBD cord-010119-t1x9gknd 11289 5 an an DT cord-010119-t1x9gknd 11289 6 automated automate VBN cord-010119-t1x9gknd 11289 7 blood blood NN cord-010119-t1x9gknd 11289 8 product product NN cord-010119-t1x9gknd 11289 9 delivery delivery NN cord-010119-t1x9gknd 11289 10 system system NN cord-010119-t1x9gknd 11289 11 that that WDT cord-010119-t1x9gknd 11289 12 extended extend VBD cord-010119-t1x9gknd 11289 13 blood blood NN cord-010119-t1x9gknd 11289 14 access access NN cord-010119-t1x9gknd 11289 15 to to IN cord-010119-t1x9gknd 11289 16 the the DT cord-010119-t1x9gknd 11289 17 bedside bedside NN cord-010119-t1x9gknd 11289 18 through through IN cord-010119-t1x9gknd 11289 19 the the DT cord-010119-t1x9gknd 11289 20 use use NN cord-010119-t1x9gknd 11289 21 of of IN cord-010119-t1x9gknd 11289 22 Remote Remote NNP cord-010119-t1x9gknd 11289 23 Blood Blood NNP cord-010119-t1x9gknd 11289 24 Allocation Allocation NNP cord-010119-t1x9gknd 11289 25 Devices Devices NNPS cord-010119-t1x9gknd 11289 26 , , , cord-010119-t1x9gknd 11289 27 or or CC cord-010119-t1x9gknd 11289 28 " " `` cord-010119-t1x9gknd 11289 29 smart smart JJ cord-010119-t1x9gknd 11289 30 blood blood NN cord-010119-t1x9gknd 11289 31 refrigerators refrigerator NNS cord-010119-t1x9gknd 11289 32 " " '' cord-010119-t1x9gknd 11289 33 to to TO cord-010119-t1x9gknd 11289 34 improve improve VB cord-010119-t1x9gknd 11289 35 patient patient JJ cord-010119-t1x9gknd 11289 36 safety safety NN cord-010119-t1x9gknd 11289 37 , , , cord-010119-t1x9gknd 11289 38 provide provide VB cord-010119-t1x9gknd 11289 39 timely timely JJ cord-010119-t1x9gknd 11289 40 access access NN cord-010119-t1x9gknd 11289 41 to to IN cord-010119-t1x9gknd 11289 42 blood blood NN cord-010119-t1x9gknd 11289 43 products product NNS cord-010119-t1x9gknd 11289 44 , , , cord-010119-t1x9gknd 11289 45 and and CC cord-010119-t1x9gknd 11289 46 potentially potentially RB cord-010119-t1x9gknd 11289 47 reduce reduce VB cord-010119-t1x9gknd 11289 48 laboratory laboratory NN cord-010119-t1x9gknd 11289 49 workload workload NN cord-010119-t1x9gknd 11289 50 . . . cord-010119-t1x9gknd 11290 1 As as IN cord-010119-t1x9gknd 11290 2 part part NN cord-010119-t1x9gknd 11290 3 of of IN cord-010119-t1x9gknd 11290 4 this this DT cord-010119-t1x9gknd 11290 5 initiative initiative NN cord-010119-t1x9gknd 11290 6 , , , cord-010119-t1x9gknd 11290 7 BloodTrack BloodTrack NNP cord-010119-t1x9gknd 11290 8 HaemoBanks HaemoBanks NNP cord-010119-t1x9gknd 11290 9 ( ( -LRB- cord-010119-t1x9gknd 11290 10 HB HB NNP cord-010119-t1x9gknd 11290 11 ) ) -RRB- cord-010119-t1x9gknd 11290 12 ( ( -LRB- cord-010119-t1x9gknd 11290 13 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 11290 14 , , , cord-010119-t1x9gknd 11290 15 Braintree Braintree NNP cord-010119-t1x9gknd 11290 16 , , , cord-010119-t1x9gknd 11290 17 MA MA NNP cord-010119-t1x9gknd 11290 18 ) ) -RRB- cord-010119-t1x9gknd 11290 19 were be VBD cord-010119-t1x9gknd 11290 20 installed instal VBN cord-010119-t1x9gknd 11290 21 and and CC cord-010119-t1x9gknd 11290 22 interfaced interface VBN cord-010119-t1x9gknd 11290 23 to to IN cord-010119-t1x9gknd 11290 24 the the DT cord-010119-t1x9gknd 11290 25 existing exist VBG cord-010119-t1x9gknd 11290 26 SafeTrace SafeTrace NNP cord-010119-t1x9gknd 11290 27 Tx Tx NNP cord-010119-t1x9gknd 11291 1 ( ( -LRB- cord-010119-t1x9gknd 11291 2 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 11291 3 , , , cord-010119-t1x9gknd 11291 4 Braintree Braintree NNP cord-010119-t1x9gknd 11291 5 , , , cord-010119-t1x9gknd 11291 6 MA MA NNP cord-010119-t1x9gknd 11291 7 ) ) -RRB- cord-010119-t1x9gknd 11291 8 Laboratory Laboratory NNP cord-010119-t1x9gknd 11291 9 Information Information NNP cord-010119-t1x9gknd 11291 10 System System NNP cord-010119-t1x9gknd 11291 11 . . . cord-010119-t1x9gknd 11292 1 One one CD cord-010119-t1x9gknd 11292 2 HB HB NNP cord-010119-t1x9gknd 11292 3 was be VBD cord-010119-t1x9gknd 11292 4 installed instal VBN cord-010119-t1x9gknd 11292 5 in in IN cord-010119-t1x9gknd 11292 6 the the DT cord-010119-t1x9gknd 11292 7 Methodist Methodist NNP cord-010119-t1x9gknd 11292 8 Hospital Hospital NNP cord-010119-t1x9gknd 11292 9 ( ( -LRB- cord-010119-t1x9gknd 11292 10 RMH RMH NNP cord-010119-t1x9gknd 11292 11 ) ) -RRB- cord-010119-t1x9gknd 11292 12 campus campus NN cord-010119-t1x9gknd 11292 13 which which WDT cord-010119-t1x9gknd 11292 14 includes include VBZ cord-010119-t1x9gknd 11292 15 a a DT cord-010119-t1x9gknd 11292 16 busy busy JJ cord-010119-t1x9gknd 11292 17 outpatient outpatient NN cord-010119-t1x9gknd 11292 18 Infusion Infusion NNP cord-010119-t1x9gknd 11292 19 Therapy Therapy NNP cord-010119-t1x9gknd 11292 20 Center Center NNP cord-010119-t1x9gknd 11292 21 ( ( -LRB- cord-010119-t1x9gknd 11292 22 ITC ITC NNP cord-010119-t1x9gknd 11292 23 ) ) -RRB- cord-010119-t1x9gknd 11292 24 . . . cord-010119-t1x9gknd 11293 1 Study Study NNP cord-010119-t1x9gknd 11293 2 Design Design NNP cord-010119-t1x9gknd 11293 3 / / SYM cord-010119-t1x9gknd 11293 4 Method method NN cord-010119-t1x9gknd 11293 5 : : : cord-010119-t1x9gknd 11294 1 An an DT cord-010119-t1x9gknd 11294 2 assessment assessment NN cord-010119-t1x9gknd 11294 3 of of IN cord-010119-t1x9gknd 11294 4 the the DT cord-010119-t1x9gknd 11294 5 current current JJ cord-010119-t1x9gknd 11294 6 blood blood NN cord-010119-t1x9gknd 11294 7 supply supply NN cord-010119-t1x9gknd 11294 8 chain chain NN cord-010119-t1x9gknd 11294 9 revealed reveal VBD cord-010119-t1x9gknd 11294 10 improvement improvement NN cord-010119-t1x9gknd 11294 11 opportunities opportunity NNS cord-010119-t1x9gknd 11294 12 for for IN cord-010119-t1x9gknd 11294 13 both both DT cord-010119-t1x9gknd 11294 14 nursing nursing NN cord-010119-t1x9gknd 11294 15 and and CC cord-010119-t1x9gknd 11294 16 blood blood NN cord-010119-t1x9gknd 11294 17 bank bank NN cord-010119-t1x9gknd 11294 18 staff staff NN cord-010119-t1x9gknd 11294 19 . . . cord-010119-t1x9gknd 11295 1 Frequent frequent JJ cord-010119-t1x9gknd 11295 2 daily daily JJ cord-010119-t1x9gknd 11295 3 trips trip NNS cord-010119-t1x9gknd 11295 4 to to IN cord-010119-t1x9gknd 11295 5 and and CC cord-010119-t1x9gknd 11295 6 from from IN cord-010119-t1x9gknd 11295 7 the the DT cord-010119-t1x9gknd 11295 8 blood blood NN cord-010119-t1x9gknd 11295 9 bank bank NN cord-010119-t1x9gknd 11295 10 take take VBP cord-010119-t1x9gknd 11295 11 nurses nurse NNS cord-010119-t1x9gknd 11295 12 away away RB cord-010119-t1x9gknd 11295 13 from from IN cord-010119-t1x9gknd 11295 14 the the DT cord-010119-t1x9gknd 11295 15 patient patient NN cord-010119-t1x9gknd 11295 16 beside beside RB cord-010119-t1x9gknd 11295 17 and and CC cord-010119-t1x9gknd 11295 18 can can MD cord-010119-t1x9gknd 11295 19 create create VB cord-010119-t1x9gknd 11295 20 congestion congestion NN cord-010119-t1x9gknd 11295 21 at at IN cord-010119-t1x9gknd 11295 22 the the DT cord-010119-t1x9gknd 11295 23 blood blood NN cord-010119-t1x9gknd 11295 24 bank bank NN cord-010119-t1x9gknd 11295 25 window window NN cord-010119-t1x9gknd 11295 26 during during IN cord-010119-t1x9gknd 11295 27 peak peak NN cord-010119-t1x9gknd 11295 28 times time NNS cord-010119-t1x9gknd 11295 29 . . . cord-010119-t1x9gknd 11296 1 For for IN cord-010119-t1x9gknd 11296 2 the the DT cord-010119-t1x9gknd 11296 3 ITC ITC NNP cord-010119-t1x9gknd 11296 4 , , , cord-010119-t1x9gknd 11296 5 with with IN cord-010119-t1x9gknd 11296 6 a a DT cord-010119-t1x9gknd 11296 7 daily daily JJ cord-010119-t1x9gknd 11296 8 outpatient outpatient NN cord-010119-t1x9gknd 11296 9 volume volume NN cord-010119-t1x9gknd 11296 10 of of IN cord-010119-t1x9gknd 11296 11 140 140 CD cord-010119-t1x9gknd 11296 12 - - SYM cord-010119-t1x9gknd 11296 13 160 160 CD cord-010119-t1x9gknd 11296 14 patients patient NNS cord-010119-t1x9gknd 11296 15 and and CC cord-010119-t1x9gknd 11296 16 an an DT cord-010119-t1x9gknd 11296 17 average average JJ cord-010119-t1x9gknd 11296 18 , , , cord-010119-t1x9gknd 11296 19 round round JJ cord-010119-t1x9gknd 11296 20 - - HYPH cord-010119-t1x9gknd 11296 21 trip trip NN cord-010119-t1x9gknd 11296 22 travel travel NN cord-010119-t1x9gknd 11296 23 time time NN cord-010119-t1x9gknd 11296 24 of of IN cord-010119-t1x9gknd 11296 25 approximately approximately RB cord-010119-t1x9gknd 11296 26 15-minutes 15-minutes CD cord-010119-t1x9gknd 11296 27 , , , cord-010119-t1x9gknd 11296 28 even even RB cord-010119-t1x9gknd 11296 29 small small JJ cord-010119-t1x9gknd 11296 30 delays delay NNS cord-010119-t1x9gknd 11296 31 waiting wait VBG cord-010119-t1x9gknd 11296 32 in in IN cord-010119-t1x9gknd 11296 33 line line NN cord-010119-t1x9gknd 11296 34 at at IN cord-010119-t1x9gknd 11296 35 the the DT cord-010119-t1x9gknd 11296 36 blood blood NN cord-010119-t1x9gknd 11296 37 bank bank NN cord-010119-t1x9gknd 11296 38 window window NN cord-010119-t1x9gknd 11296 39 would would MD cord-010119-t1x9gknd 11296 40 produce produce VB cord-010119-t1x9gknd 11296 41 profound profound JJ cord-010119-t1x9gknd 11296 42 ripple ripple JJ cord-010119-t1x9gknd 11296 43 effects effect NNS cord-010119-t1x9gknd 11296 44 . . . cord-010119-t1x9gknd 11297 1 ITC ITC NNP cord-010119-t1x9gknd 11297 2 nurses nurse NNS cord-010119-t1x9gknd 11297 3 faced face VBD cord-010119-t1x9gknd 11297 4 the the DT cord-010119-t1x9gknd 11297 5 additional additional JJ cord-010119-t1x9gknd 11297 6 challenge challenge NN cord-010119-t1x9gknd 11297 7 of of IN cord-010119-t1x9gknd 11297 8 maintaining maintain VBG cord-010119-t1x9gknd 11297 9 nurse nurse NN cord-010119-t1x9gknd 11297 10 - - HYPH cord-010119-t1x9gknd 11297 11 to to IN cord-010119-t1x9gknd 11297 12 - - HYPH cord-010119-t1x9gknd 11297 13 patient patient NN cord-010119-t1x9gknd 11297 14 ratios ratio NNS cord-010119-t1x9gknd 11297 15 and and CC cord-010119-t1x9gknd 11297 16 providing provide VBG cord-010119-t1x9gknd 11297 17 timely timely JJ cord-010119-t1x9gknd 11297 18 patient patient JJ cord-010119-t1x9gknd 11297 19 care care NN cord-010119-t1x9gknd 11297 20 . . . cord-010119-t1x9gknd 11298 1 About about RB cord-010119-t1x9gknd 11298 2 30 30 CD cord-010119-t1x9gknd 11298 3 % % NN cord-010119-t1x9gknd 11298 4 of of IN cord-010119-t1x9gknd 11298 5 patients patient NNS cord-010119-t1x9gknd 11298 6 in in IN cord-010119-t1x9gknd 11298 7 the the DT cord-010119-t1x9gknd 11298 8 ITC ITC NNP cord-010119-t1x9gknd 11298 9 have have VBP cord-010119-t1x9gknd 11298 10 same same JJ cord-010119-t1x9gknd 11298 11 - - HYPH cord-010119-t1x9gknd 11298 12 day day NN cord-010119-t1x9gknd 11298 13 transfusion transfusion NN cord-010119-t1x9gknd 11298 14 orders order NNS cord-010119-t1x9gknd 11298 15 , , , cord-010119-t1x9gknd 11298 16 adding add VBG cord-010119-t1x9gknd 11298 17 to to IN cord-010119-t1x9gknd 11298 18 the the DT cord-010119-t1x9gknd 11298 19 blood blood NN cord-010119-t1x9gknd 11298 20 bank bank NN cord-010119-t1x9gknd 11298 21 workload workload NN cord-010119-t1x9gknd 11298 22 and and CC cord-010119-t1x9gknd 11298 23 creating create VBG cord-010119-t1x9gknd 11298 24 unpredictability unpredictability NN cord-010119-t1x9gknd 11298 25 in in IN cord-010119-t1x9gknd 11298 26 workflow workflow NN cord-010119-t1x9gknd 11298 27 . . . cord-010119-t1x9gknd 11299 1 Often often RB cord-010119-t1x9gknd 11299 2 for for IN cord-010119-t1x9gknd 11299 3 patients patient NNS cord-010119-t1x9gknd 11299 4 in in IN cord-010119-t1x9gknd 11299 5 the the DT cord-010119-t1x9gknd 11299 6 ITC ITC NNP cord-010119-t1x9gknd 11299 7 , , , cord-010119-t1x9gknd 11299 8 nurses nurse NNS cord-010119-t1x9gknd 11299 9 had have VBD cord-010119-t1x9gknd 11299 10 to to TO cord-010119-t1x9gknd 11299 11 repeat repeat VB cord-010119-t1x9gknd 11299 12 pre pre JJ cord-010119-t1x9gknd 11299 13 - - JJ cord-010119-t1x9gknd 11299 14 transfusion transfusion JJ cord-010119-t1x9gknd 11299 15 vital vital JJ cord-010119-t1x9gknd 11299 16 signs sign NNS cord-010119-t1x9gknd 11299 17 because because IN cord-010119-t1x9gknd 11299 18 too too RB cord-010119-t1x9gknd 11299 19 much much JJ cord-010119-t1x9gknd 11299 20 time time NN cord-010119-t1x9gknd 11299 21 had have VBD cord-010119-t1x9gknd 11299 22 elapsed elapse VBN cord-010119-t1x9gknd 11299 23 between between IN cord-010119-t1x9gknd 11299 24 gathering gather VBG cord-010119-t1x9gknd 11299 25 vitals vital NNS cord-010119-t1x9gknd 11299 26 and and CC cord-010119-t1x9gknd 11299 27 obtaining obtain VBG cord-010119-t1x9gknd 11299 28 the the DT cord-010119-t1x9gknd 11299 29 blood blood NN cord-010119-t1x9gknd 11299 30 . . . cord-010119-t1x9gknd 11300 1 These these DT cord-010119-t1x9gknd 11300 2 inefficiencies inefficiency NNS cord-010119-t1x9gknd 11300 3 resulted result VBD cord-010119-t1x9gknd 11300 4 in in IN cord-010119-t1x9gknd 11300 5 longer long JJR cord-010119-t1x9gknd 11300 6 patient patient JJ cord-010119-t1x9gknd 11300 7 wait wait VB cord-010119-t1x9gknd 11300 8 times time NNS cord-010119-t1x9gknd 11300 9 and and CC cord-010119-t1x9gknd 11300 10 , , , cord-010119-t1x9gknd 11300 11 ultimately ultimately RB cord-010119-t1x9gknd 11300 12 , , , cord-010119-t1x9gknd 11300 13 a a DT cord-010119-t1x9gknd 11300 14 longer long RBR cord-010119-t1x9gknd 11300 15 stay stay NN cord-010119-t1x9gknd 11300 16 in in IN cord-010119-t1x9gknd 11300 17 the the DT cord-010119-t1x9gknd 11300 18 ITC ITC NNP cord-010119-t1x9gknd 11300 19 . . . cord-010119-t1x9gknd 11301 1 Results/ Results/ . cord-010119-t1x9gknd 11302 1 Finding finding NN cord-010119-t1x9gknd 11302 2 : : : cord-010119-t1x9gknd 11303 1 HB HB NNP cord-010119-t1x9gknd 11303 2 devices device NNS cord-010119-t1x9gknd 11303 3 allow allow VBP cord-010119-t1x9gknd 11303 4 nursing nursing NN cord-010119-t1x9gknd 11303 5 staff staff NN cord-010119-t1x9gknd 11303 6 to to TO cord-010119-t1x9gknd 11303 7 access access VB cord-010119-t1x9gknd 11303 8 red red JJ cord-010119-t1x9gknd 11303 9 blood blood NN cord-010119-t1x9gknd 11303 10 cells cell NNS cord-010119-t1x9gknd 11303 11 ( ( -LRB- cord-010119-t1x9gknd 11303 12 RBC RBC NNP cord-010119-t1x9gknd 11303 13 ) ) -RRB- cord-010119-t1x9gknd 11303 14 for for IN cord-010119-t1x9gknd 11303 15 the the DT cord-010119-t1x9gknd 11303 16 majority majority NN cord-010119-t1x9gknd 11303 17 of of IN cord-010119-t1x9gknd 11303 18 their -PRON- PRP$ cord-010119-t1x9gknd 11303 19 patients patient NNS cord-010119-t1x9gknd 11303 20 at at IN cord-010119-t1x9gknd 11303 21 the the DT cord-010119-t1x9gknd 11303 22 point point NN cord-010119-t1x9gknd 11303 23 of of IN cord-010119-t1x9gknd 11303 24 care care NN cord-010119-t1x9gknd 11303 25 . . . cord-010119-t1x9gknd 11304 1 Since since IN cord-010119-t1x9gknd 11304 2 implementing implement VBG cord-010119-t1x9gknd 11304 3 in in IN cord-010119-t1x9gknd 11304 4 November November NNP cord-010119-t1x9gknd 11304 5 2015 2015 CD cord-010119-t1x9gknd 11304 6 , , , cord-010119-t1x9gknd 11304 7 the the DT cord-010119-t1x9gknd 11304 8 HB HB NNP cord-010119-t1x9gknd 11304 9 has have VBZ cord-010119-t1x9gknd 11304 10 significantly significantly RB cord-010119-t1x9gknd 11304 11 improved improve VBN cord-010119-t1x9gknd 11304 12 the the DT cord-010119-t1x9gknd 11304 13 turnaround turnaround NN cord-010119-t1x9gknd 11304 14 time time NN cord-010119-t1x9gknd 11304 15 of of IN cord-010119-t1x9gknd 11304 16 RBC RBC NNP cord-010119-t1x9gknd 11304 17 issue issue NN cord-010119-t1x9gknd 11304 18 -from -from . cord-010119-t1x9gknd 11305 1 15-minutes 15-minutes CD cord-010119-t1x9gknd 11305 2 to to IN cord-010119-t1x9gknd 11305 3 less less JJR cord-010119-t1x9gknd 11305 4 than than IN cord-010119-t1x9gknd 11305 5 60-seconds 60-seconds CD cord-010119-t1x9gknd 11305 6 - - : cord-010119-t1x9gknd 11305 7 and and CC cord-010119-t1x9gknd 11305 8 helped help VBD cord-010119-t1x9gknd 11305 9 maintain maintain VB cord-010119-t1x9gknd 11305 10 nurse nurse NN cord-010119-t1x9gknd 11305 11 to to IN cord-010119-t1x9gknd 11305 12 patient patient JJ cord-010119-t1x9gknd 11305 13 ratios ratio NNS cord-010119-t1x9gknd 11305 14 and and CC cord-010119-t1x9gknd 11305 15 reduced reduce VBN cord-010119-t1x9gknd 11305 16 traffic traffic NN cord-010119-t1x9gknd 11305 17 at at IN cord-010119-t1x9gknd 11305 18 the the DT cord-010119-t1x9gknd 11305 19 blood blood NN cord-010119-t1x9gknd 11305 20 bank bank NN cord-010119-t1x9gknd 11305 21 issue issue NN cord-010119-t1x9gknd 11305 22 window window NN cord-010119-t1x9gknd 11305 23 . . . cord-010119-t1x9gknd 11306 1 Prior prior RB cord-010119-t1x9gknd 11306 2 to to IN cord-010119-t1x9gknd 11306 3 HB HB NNP cord-010119-t1x9gknd 11306 4 implementation implementation NN cord-010119-t1x9gknd 11306 5 , , , cord-010119-t1x9gknd 11306 6 blood blood NN cord-010119-t1x9gknd 11306 7 bank bank NN cord-010119-t1x9gknd 11306 8 staff staff NN cord-010119-t1x9gknd 11306 9 at at IN cord-010119-t1x9gknd 11306 10 RMH RMH NNP cord-010119-t1x9gknd 11306 11 were be VBD cord-010119-t1x9gknd 11306 12 issuing issue VBG cord-010119-t1x9gknd 11306 13 approximately approximately RB cord-010119-t1x9gknd 11306 14 750 750 CD cord-010119-t1x9gknd 11306 15 RBC RBC NNP cord-010119-t1x9gknd 11306 16 per per IN cord-010119-t1x9gknd 11306 17 month month NN cord-010119-t1x9gknd 11306 18 out out IN cord-010119-t1x9gknd 11306 19 of of IN cord-010119-t1x9gknd 11306 20 the the DT cord-010119-t1x9gknd 11306 21 window window NN cord-010119-t1x9gknd 11306 22 for for IN cord-010119-t1x9gknd 11306 23 non non JJ cord-010119-t1x9gknd 11306 24 - - JJ cord-010119-t1x9gknd 11306 25 surgical surgical JJ cord-010119-t1x9gknd 11306 26 patients patient NNS cord-010119-t1x9gknd 11306 27 . . . cord-010119-t1x9gknd 11307 1 This this DT cord-010119-t1x9gknd 11307 2 has have VBZ cord-010119-t1x9gknd 11307 3 been be VBN cord-010119-t1x9gknd 11307 4 reduced reduce VBN cord-010119-t1x9gknd 11307 5 to to IN cord-010119-t1x9gknd 11307 6 approximately approximately RB cord-010119-t1x9gknd 11307 7 300 300 CD cord-010119-t1x9gknd 11307 8 RBC RBC NNP cord-010119-t1x9gknd 11307 9 per per IN cord-010119-t1x9gknd 11307 10 month month NN cord-010119-t1x9gknd 11307 11 , , , cord-010119-t1x9gknd 11307 12 a a DT cord-010119-t1x9gknd 11307 13 60 60 CD cord-010119-t1x9gknd 11307 14 % % NN cord-010119-t1x9gknd 11307 15 average average JJ cord-010119-t1x9gknd 11307 16 monthly monthly JJ cord-010119-t1x9gknd 11307 17 reduction reduction NN cord-010119-t1x9gknd 11307 18 . . . cord-010119-t1x9gknd 11308 1 Conclusion conclusion NN cord-010119-t1x9gknd 11308 2 : : : cord-010119-t1x9gknd 11309 1 Having have VBG cord-010119-t1x9gknd 11309 2 the the DT cord-010119-t1x9gknd 11309 3 HB HB NNP cord-010119-t1x9gknd 11309 4 located locate VBN cord-010119-t1x9gknd 11309 5 in in IN cord-010119-t1x9gknd 11309 6 the the DT cord-010119-t1x9gknd 11309 7 ITC ITC NNP cord-010119-t1x9gknd 11309 8 has have VBZ cord-010119-t1x9gknd 11309 9 helped help VBN cord-010119-t1x9gknd 11309 10 to to TO cord-010119-t1x9gknd 11309 11 expedite expedite VB cord-010119-t1x9gknd 11309 12 the the DT cord-010119-t1x9gknd 11309 13 care care NN cord-010119-t1x9gknd 11309 14 of of IN cord-010119-t1x9gknd 11309 15 patients patient NNS cord-010119-t1x9gknd 11309 16 and and CC cord-010119-t1x9gknd 11309 17 more more RBR cord-010119-t1x9gknd 11309 18 easily easily RB cord-010119-t1x9gknd 11309 19 manage manage VB cord-010119-t1x9gknd 11309 20 blood blood NN cord-010119-t1x9gknd 11309 21 products product NNS cord-010119-t1x9gknd 11309 22 for for IN cord-010119-t1x9gknd 11309 23 patients patient NNS cord-010119-t1x9gknd 11309 24 with with IN cord-010119-t1x9gknd 11309 25 same same JJ cord-010119-t1x9gknd 11309 26 - - HYPH cord-010119-t1x9gknd 11309 27 day day NN cord-010119-t1x9gknd 11309 28 orders order NNS cord-010119-t1x9gknd 11309 29 . . . cord-010119-t1x9gknd 11310 1 The the DT cord-010119-t1x9gknd 11310 2 use use NN cord-010119-t1x9gknd 11310 3 of of IN cord-010119-t1x9gknd 11310 4 HB HB NNP cord-010119-t1x9gknd 11310 5 devices device NNS cord-010119-t1x9gknd 11310 6 has have VBZ cord-010119-t1x9gknd 11310 7 not not RB cord-010119-t1x9gknd 11310 8 resulted result VBN cord-010119-t1x9gknd 11310 9 in in IN cord-010119-t1x9gknd 11310 10 a a DT cord-010119-t1x9gknd 11310 11 reduction reduction NN cord-010119-t1x9gknd 11310 12 in in IN cord-010119-t1x9gknd 11310 13 blood blood NN cord-010119-t1x9gknd 11310 14 bank bank NN cord-010119-t1x9gknd 11310 15 FTE FTE NNP cord-010119-t1x9gknd 11310 16 , , , cord-010119-t1x9gknd 11310 17 but but CC cord-010119-t1x9gknd 11310 18 rather rather RB cord-010119-t1x9gknd 11310 19 a a DT cord-010119-t1x9gknd 11310 20 shift shift NN cord-010119-t1x9gknd 11310 21 in in IN cord-010119-t1x9gknd 11310 22 workload workload NN cord-010119-t1x9gknd 11310 23 ; ; : cord-010119-t1x9gknd 11310 24 from from IN cord-010119-t1x9gknd 11310 25 issuing issue VBG cord-010119-t1x9gknd 11310 26 products product NNS cord-010119-t1x9gknd 11310 27 to to IN cord-010119-t1x9gknd 11310 28 monitoring monitor VBG cord-010119-t1x9gknd 11310 29 inventory inventory NN cord-010119-t1x9gknd 11310 30 and and CC cord-010119-t1x9gknd 11310 31 restocking restocking NN cord-010119-t1x9gknd 11310 32 . . . cord-010119-t1x9gknd 11311 1 consists consist VBZ cord-010119-t1x9gknd 11311 2 of of IN cord-010119-t1x9gknd 11311 3 registered register VBN cord-010119-t1x9gknd 11311 4 paramedics paramedic NNS cord-010119-t1x9gknd 11311 5 that that WDT cord-010119-t1x9gknd 11311 6 are be VBP cord-010119-t1x9gknd 11311 7 pararescue pararescue NN cord-010119-t1x9gknd 11311 8 specialists specialist NNS cord-010119-t1x9gknd 11311 9 and and CC cord-010119-t1x9gknd 11311 10 helicopter helicopter NN cord-010119-t1x9gknd 11311 11 personnel personnel NNS cord-010119-t1x9gknd 11311 12 . . . cord-010119-t1x9gknd 11312 1 When when WRB cord-010119-t1x9gknd 11312 2 in in IN cord-010119-t1x9gknd 11312 3 combat combat NN cord-010119-t1x9gknd 11312 4 , , , cord-010119-t1x9gknd 11312 5 the the DT cord-010119-t1x9gknd 11312 6 squadron squadron NN cord-010119-t1x9gknd 11312 7 conducts conduct VBZ cord-010119-t1x9gknd 11312 8 personnel personnel NNS cord-010119-t1x9gknd 11312 9 recovery recovery NN cord-010119-t1x9gknd 11312 10 operations operation NNS cord-010119-t1x9gknd 11312 11 and and CC cord-010119-t1x9gknd 11312 12 rescues rescue NNS cord-010119-t1x9gknd 11312 13 downed down VBN cord-010119-t1x9gknd 11312 14 airmen airman NNS cord-010119-t1x9gknd 11312 15 . . . cord-010119-t1x9gknd 11313 1 When when WRB cord-010119-t1x9gknd 11313 2 stationed station VBN cord-010119-t1x9gknd 11313 3 in in IN cord-010119-t1x9gknd 11313 4 the the DT cord-010119-t1x9gknd 11313 5 US US NNP cord-010119-t1x9gknd 11313 6 , , , cord-010119-t1x9gknd 11313 7 they -PRON- PRP cord-010119-t1x9gknd 11313 8 mitigate mitigate VBP cord-010119-t1x9gknd 11313 9 in in IN cord-010119-t1x9gknd 11313 10 state state NN cord-010119-t1x9gknd 11313 11 emergencies emergency NNS cord-010119-t1x9gknd 11313 12 and and CC cord-010119-t1x9gknd 11313 13 perform perform VB cord-010119-t1x9gknd 11313 14 aeromedical aeromedical JJ cord-010119-t1x9gknd 11313 15 evacuations evacuation NNS cord-010119-t1x9gknd 11313 16 . . . cord-010119-t1x9gknd 11314 1 In in IN cord-010119-t1x9gknd 11314 2 2015 2015 CD cord-010119-t1x9gknd 11314 3 , , , cord-010119-t1x9gknd 11314 4 they -PRON- PRP cord-010119-t1x9gknd 11314 5 supported support VBD cord-010119-t1x9gknd 11314 6 a a DT cord-010119-t1x9gknd 11314 7 civilian civilian JJ cord-010119-t1x9gknd 11314 8 medical medical JJ cord-010119-t1x9gknd 11314 9 emergency emergency NN cord-010119-t1x9gknd 11314 10 and and CC cord-010119-t1x9gknd 11314 11 the the DT cord-010119-t1x9gknd 11314 12 patient patient NN cord-010119-t1x9gknd 11314 13 needed need VBD cord-010119-t1x9gknd 11314 14 a a DT cord-010119-t1x9gknd 11314 15 transfusion transfusion NN cord-010119-t1x9gknd 11314 16 in in IN cord-010119-t1x9gknd 11314 17 the the DT cord-010119-t1x9gknd 11314 18 field field NN cord-010119-t1x9gknd 11314 19 . . . cord-010119-t1x9gknd 11315 1 They -PRON- PRP cord-010119-t1x9gknd 11315 2 procured procure VBD cord-010119-t1x9gknd 11315 3 blood blood NN cord-010119-t1x9gknd 11315 4 products product NNS cord-010119-t1x9gknd 11315 5 from from IN cord-010119-t1x9gknd 11315 6 a a DT cord-010119-t1x9gknd 11315 7 distant distant JJ cord-010119-t1x9gknd 11315 8 air air NN cord-010119-t1x9gknd 11315 9 force force NN cord-010119-t1x9gknd 11315 10 base base NN cord-010119-t1x9gknd 11315 11 with with IN cord-010119-t1x9gknd 11315 12 adjacent adjacent JJ cord-010119-t1x9gknd 11315 13 medical medical JJ cord-010119-t1x9gknd 11315 14 facility facility NN cord-010119-t1x9gknd 11315 15 . . . cord-010119-t1x9gknd 11316 1 At at IN cord-010119-t1x9gknd 11316 2 the the DT cord-010119-t1x9gknd 11316 3 debriefing debriefing NN cord-010119-t1x9gknd 11316 4 , , , cord-010119-t1x9gknd 11316 5 members member NNS cord-010119-t1x9gknd 11316 6 of of IN cord-010119-t1x9gknd 11316 7 the the DT cord-010119-t1x9gknd 11316 8 131 131 CD cord-010119-t1x9gknd 11316 9 st st NNP cord-010119-t1x9gknd 11316 10 Rescue Rescue NNP cord-010119-t1x9gknd 11316 11 Squadron Squadron NNP cord-010119-t1x9gknd 11316 12 ( ( -LRB- cord-010119-t1x9gknd 11316 13 131 131 CD cord-010119-t1x9gknd 11316 14 RQS RQS NNP cord-010119-t1x9gknd 11316 15 ) ) -RRB- cord-010119-t1x9gknd 11316 16 decided decide VBD cord-010119-t1x9gknd 11316 17 to to TO cord-010119-t1x9gknd 11316 18 find find VB cord-010119-t1x9gknd 11316 19 a a DT cord-010119-t1x9gknd 11316 20 local local JJ cord-010119-t1x9gknd 11316 21 civilian civilian JJ cord-010119-t1x9gknd 11316 22 blood blood NN cord-010119-t1x9gknd 11316 23 supplier supplier NN cord-010119-t1x9gknd 11316 24 . . . cord-010119-t1x9gknd 11317 1 The the DT cord-010119-t1x9gknd 11317 2 Master Master NNP cord-010119-t1x9gknd 11317 3 Sergeant Sergeant NNP cord-010119-t1x9gknd 11317 4 contacted contact VBD cord-010119-t1x9gknd 11317 5 our -PRON- PRP$ cord-010119-t1x9gknd 11317 6 blood blood NN cord-010119-t1x9gknd 11317 7 center center NN cord-010119-t1x9gknd 11317 8 and and CC cord-010119-t1x9gknd 11317 9 set set VBD cord-010119-t1x9gknd 11317 10 up up RP cord-010119-t1x9gknd 11317 11 a a DT cord-010119-t1x9gknd 11317 12 contract contract NN cord-010119-t1x9gknd 11317 13 for for IN cord-010119-t1x9gknd 11317 14 blood blood NN cord-010119-t1x9gknd 11317 15 supply supply NN cord-010119-t1x9gknd 11317 16 . . . cord-010119-t1x9gknd 11318 1 Study Study NNP cord-010119-t1x9gknd 11318 2 Design Design NNP cord-010119-t1x9gknd 11318 3 / / SYM cord-010119-t1x9gknd 11318 4 Method method NN cord-010119-t1x9gknd 11318 5 : : : cord-010119-t1x9gknd 11319 1 Blood blood NN cord-010119-t1x9gknd 11319 2 center center NN cord-010119-t1x9gknd 11319 3 representatives representative NNS cord-010119-t1x9gknd 11319 4 met meet VBD cord-010119-t1x9gknd 11319 5 with with IN cord-010119-t1x9gknd 11319 6 the the DT cord-010119-t1x9gknd 11319 7 131 131 CD cord-010119-t1x9gknd 11319 8 RQS RQS NNP cord-010119-t1x9gknd 11319 9 Master Master NNP cord-010119-t1x9gknd 11319 10 Sergeant Sergeant NNP cord-010119-t1x9gknd 11319 11 in in IN cord-010119-t1x9gknd 11319 12 January January NNP cord-010119-t1x9gknd 11319 13 2016 2016 CD cord-010119-t1x9gknd 11319 14 . . . cord-010119-t1x9gknd 11320 1 We -PRON- PRP cord-010119-t1x9gknd 11320 2 asked ask VBD cord-010119-t1x9gknd 11320 3 what what WP cord-010119-t1x9gknd 11320 4 131 131 CD cord-010119-t1x9gknd 11320 5 RQS RQS NNP cord-010119-t1x9gknd 11320 6 's 's POS cord-010119-t1x9gknd 11320 7 order order NN cord-010119-t1x9gknd 11320 8 and and CC cord-010119-t1x9gknd 11320 9 delivery delivery NN cord-010119-t1x9gknd 11320 10 expectations expectation NNS cord-010119-t1x9gknd 11320 11 were be VBD cord-010119-t1x9gknd 11320 12 . . . cord-010119-t1x9gknd 11321 1 He -PRON- PRP cord-010119-t1x9gknd 11321 2 said say VBD cord-010119-t1x9gknd 11321 3 sporadic sporadic JJ cord-010119-t1x9gknd 11321 4 use use NN cord-010119-t1x9gknd 11321 5 and and CC cord-010119-t1x9gknd 11321 6 the the DT cord-010119-t1x9gknd 11321 7 blood blood NN cord-010119-t1x9gknd 11321 8 order order NN cord-010119-t1x9gknd 11321 9 would would MD cord-010119-t1x9gknd 11321 10 be be VB cord-010119-t1x9gknd 11321 11 2 2 CD cord-010119-t1x9gknd 11321 12 RBCs rbc NNS cord-010119-t1x9gknd 11321 13 . . . cord-010119-t1x9gknd 11322 1 We -PRON- PRP cord-010119-t1x9gknd 11322 2 wrote write VBD cord-010119-t1x9gknd 11322 3 a a DT cord-010119-t1x9gknd 11322 4 procedure procedure NN cord-010119-t1x9gknd 11322 5 for for IN cord-010119-t1x9gknd 11322 6 consignment consignment NN cord-010119-t1x9gknd 11322 7 and and CC cord-010119-t1x9gknd 11322 8 packaging packaging NN cord-010119-t1x9gknd 11322 9 , , , cord-010119-t1x9gknd 11322 10 using use VBG cord-010119-t1x9gknd 11322 11 standard standard JJ cord-010119-t1x9gknd 11322 12 blood blood NN cord-010119-t1x9gknd 11322 13 transport transport NN cord-010119-t1x9gknd 11322 14 boxes box NNS cord-010119-t1x9gknd 11322 15 . . . cord-010119-t1x9gknd 11323 1 We -PRON- PRP cord-010119-t1x9gknd 11323 2 developed develop VBD cord-010119-t1x9gknd 11323 3 a a DT cord-010119-t1x9gknd 11323 4 communication communication NN cord-010119-t1x9gknd 11323 5 template template NN cord-010119-t1x9gknd 11323 6 for for IN cord-010119-t1x9gknd 11323 7 staff staff NN cord-010119-t1x9gknd 11323 8 to to TO cord-010119-t1x9gknd 11323 9 anticipate anticipate VB cord-010119-t1x9gknd 11323 10 the the DT cord-010119-t1x9gknd 11323 11 131 131 CD cord-010119-t1x9gknd 11323 12 RQS RQS NNP cord-010119-t1x9gknd 11323 13 needs need NNS cord-010119-t1x9gknd 11323 14 . . . cord-010119-t1x9gknd 11324 1 Staff staff NN cord-010119-t1x9gknd 11324 2 was be VBD cord-010119-t1x9gknd 11324 3 trained train VBN cord-010119-t1x9gknd 11324 4 based base VBN cord-010119-t1x9gknd 11324 5 on on IN cord-010119-t1x9gknd 11324 6 data datum NNS cord-010119-t1x9gknd 11324 7 from from IN cord-010119-t1x9gknd 11324 8 January January NNP cord-010119-t1x9gknd 11324 9 2016 2016 CD cord-010119-t1x9gknd 11324 10 meeting meeting NN cord-010119-t1x9gknd 11324 11 . . . cord-010119-t1x9gknd 11325 1 We -PRON- PRP cord-010119-t1x9gknd 11325 2 contacted contact VBD cord-010119-t1x9gknd 11325 3 the the DT cord-010119-t1x9gknd 11325 4 131 131 CD cord-010119-t1x9gknd 11325 5 RQS RQS NNP cord-010119-t1x9gknd 11325 6 in in IN cord-010119-t1x9gknd 11325 7 September September NNP cord-010119-t1x9gknd 11325 8 2016 2016 CD cord-010119-t1x9gknd 11325 9 to to TO cord-010119-t1x9gknd 11325 10 perform perform VB cord-010119-t1x9gknd 11325 11 a a DT cord-010119-t1x9gknd 11325 12 trial trial NN cord-010119-t1x9gknd 11325 13 run run NN cord-010119-t1x9gknd 11325 14 . . . cord-010119-t1x9gknd 11326 1 At at IN cord-010119-t1x9gknd 11326 2 that that DT cord-010119-t1x9gknd 11326 3 time time NN cord-010119-t1x9gknd 11326 4 , , , cord-010119-t1x9gknd 11326 5 we -PRON- PRP cord-010119-t1x9gknd 11326 6 learned learn VBD cord-010119-t1x9gknd 11326 7 the the DT cord-010119-t1x9gknd 11326 8 Master Master NNP cord-010119-t1x9gknd 11326 9 Sergeant Sergeant NNP cord-010119-t1x9gknd 11326 10 was be VBD cord-010119-t1x9gknd 11326 11 shipped ship VBN cord-010119-t1x9gknd 11326 12 out out RP cord-010119-t1x9gknd 11326 13 to to IN cord-010119-t1x9gknd 11326 14 military military JJ cord-010119-t1x9gknd 11326 15 theater theater NN cord-010119-t1x9gknd 11326 16 . . . cord-010119-t1x9gknd 11327 1 We -PRON- PRP cord-010119-t1x9gknd 11327 2 invited invite VBD cord-010119-t1x9gknd 11327 3 his -PRON- PRP$ cord-010119-t1x9gknd 11327 4 replacement replacement NN cord-010119-t1x9gknd 11327 5 to to IN cord-010119-t1x9gknd 11327 6 the the DT cord-010119-t1x9gknd 11327 7 blood blood NN cord-010119-t1x9gknd 11327 8 center center NN cord-010119-t1x9gknd 11327 9 . . . cord-010119-t1x9gknd 11328 1 This this DT cord-010119-t1x9gknd 11328 2 pararescue pararescue NN cord-010119-t1x9gknd 11328 3 Senior Senior NNP cord-010119-t1x9gknd 11328 4 Airman Airman NNP cord-010119-t1x9gknd 11328 5 had have VBD cord-010119-t1x9gknd 11328 6 just just RB cord-010119-t1x9gknd 11328 7 returned return VBN cord-010119-t1x9gknd 11328 8 from from IN cord-010119-t1x9gknd 11328 9 Syria Syria NNP cord-010119-t1x9gknd 11328 10 and and CC cord-010119-t1x9gknd 11328 11 was be VBD cord-010119-t1x9gknd 11328 12 assigned assign VBN cord-010119-t1x9gknd 11328 13 to to IN cord-010119-t1x9gknd 11328 14 civilian civilian JJ cord-010119-t1x9gknd 11328 15 duty duty NN cord-010119-t1x9gknd 11328 16 . . . cord-010119-t1x9gknd 11329 1 He -PRON- PRP cord-010119-t1x9gknd 11329 2 had have VBD cord-010119-t1x9gknd 11329 3 no no DT cord-010119-t1x9gknd 11329 4 prior prior JJ cord-010119-t1x9gknd 11329 5 knowledge knowledge NN cord-010119-t1x9gknd 11329 6 of of IN cord-010119-t1x9gknd 11329 7 the the DT cord-010119-t1x9gknd 11329 8 131 131 CD cord-010119-t1x9gknd 11329 9 RQS RQS NNP cord-010119-t1x9gknd 11329 10 association association NN cord-010119-t1x9gknd 11329 11 with with IN cord-010119-t1x9gknd 11329 12 a a DT cord-010119-t1x9gknd 11329 13 civilian civilian JJ cord-010119-t1x9gknd 11329 14 blood blood NN cord-010119-t1x9gknd 11329 15 center center NN cord-010119-t1x9gknd 11329 16 . . . cord-010119-t1x9gknd 11330 1 Based base VBN cord-010119-t1x9gknd 11330 2 on on IN cord-010119-t1x9gknd 11330 3 his -PRON- PRP$ cord-010119-t1x9gknd 11330 4 field field NN cord-010119-t1x9gknd 11330 5 experiences experience NNS cord-010119-t1x9gknd 11330 6 , , , cord-010119-t1x9gknd 11330 7 he -PRON- PRP cord-010119-t1x9gknd 11330 8 changed change VBD cord-010119-t1x9gknd 11330 9 the the DT cord-010119-t1x9gknd 11330 10 blood blood NN cord-010119-t1x9gknd 11330 11 order order NN cord-010119-t1x9gknd 11330 12 from from IN cord-010119-t1x9gknd 11330 13 2 2 CD cord-010119-t1x9gknd 11330 14 to to IN cord-010119-t1x9gknd 11330 15 6 6 CD cord-010119-t1x9gknd 11330 16 RBCs rbc NNS cord-010119-t1x9gknd 11330 17 . . . cord-010119-t1x9gknd 11331 1 He -PRON- PRP cord-010119-t1x9gknd 11331 2 introduced introduce VBD cord-010119-t1x9gknd 11331 3 blood blood NN cord-010119-t1x9gknd 11331 4 transport transport NN cord-010119-t1x9gknd 11331 5 containers container NNS cord-010119-t1x9gknd 11331 6 , , , cord-010119-t1x9gknd 11331 7 used use VBN cord-010119-t1x9gknd 11331 8 in in IN cord-010119-t1x9gknd 11331 9 military military JJ cord-010119-t1x9gknd 11331 10 operations operation NNS cord-010119-t1x9gknd 11331 11 , , , cord-010119-t1x9gknd 11331 12 saying say VBG cord-010119-t1x9gknd 11331 13 they -PRON- PRP cord-010119-t1x9gknd 11331 14 were be VBD cord-010119-t1x9gknd 11331 15 easier easy JJR cord-010119-t1x9gknd 11331 16 to to TO cord-010119-t1x9gknd 11331 17 carry carry VB cord-010119-t1x9gknd 11331 18 during during IN cord-010119-t1x9gknd 11331 19 water water NN cord-010119-t1x9gknd 11331 20 and and CC cord-010119-t1x9gknd 11331 21 land land NN cord-010119-t1x9gknd 11331 22 pararescue pararescue NN cord-010119-t1x9gknd 11331 23 missions mission NNS cord-010119-t1x9gknd 11331 24 . . . cord-010119-t1x9gknd 11332 1 We -PRON- PRP cord-010119-t1x9gknd 11332 2 rewrote rewrite VBD cord-010119-t1x9gknd 11332 3 the the DT cord-010119-t1x9gknd 11332 4 procedures procedure NNS cord-010119-t1x9gknd 11332 5 , , , cord-010119-t1x9gknd 11332 6 incorporated incorporate VBD cord-010119-t1x9gknd 11332 7 his -PRON- PRP$ cord-010119-t1x9gknd 11332 8 transport transport NN cord-010119-t1x9gknd 11332 9 containers container NNS cord-010119-t1x9gknd 11332 10 , , , cord-010119-t1x9gknd 11332 11 and and CC cord-010119-t1x9gknd 11332 12 made make VBD cord-010119-t1x9gknd 11332 13 a a DT cord-010119-t1x9gknd 11332 14 pictorial pictorial JJ cord-010119-t1x9gknd 11332 15 job job NN cord-010119-t1x9gknd 11332 16 aid aid NN cord-010119-t1x9gknd 11332 17 to to TO cord-010119-t1x9gknd 11332 18 assist assist VB cord-010119-t1x9gknd 11332 19 staff staff NN cord-010119-t1x9gknd 11332 20 on on IN cord-010119-t1x9gknd 11332 21 packaging package VBG cord-010119-t1x9gknd 11332 22 blood blood NN cord-010119-t1x9gknd 11332 23 using use VBG cord-010119-t1x9gknd 11332 24 these these DT cord-010119-t1x9gknd 11332 25 containers container NNS cord-010119-t1x9gknd 11332 26 . . . cord-010119-t1x9gknd 11333 1 The the DT cord-010119-t1x9gknd 11333 2 blood blood NN cord-010119-t1x9gknd 11333 3 center center NN cord-010119-t1x9gknd 11333 4 and and CC cord-010119-t1x9gknd 11333 5 131 131 CD cord-010119-t1x9gknd 11333 6 RQS RQS NNP cord-010119-t1x9gknd 11333 7 performed perform VBD cord-010119-t1x9gknd 11333 8 a a DT cord-010119-t1x9gknd 11333 9 mock mock JJ cord-010119-t1x9gknd 11333 10 run run NN cord-010119-t1x9gknd 11333 11 on on IN cord-010119-t1x9gknd 11333 12 October October NNP cord-010119-t1x9gknd 11333 13 31 31 CD cord-010119-t1x9gknd 11333 14 , , , cord-010119-t1x9gknd 11333 15 and and CC cord-010119-t1x9gknd 11333 16 we -PRON- PRP cord-010119-t1x9gknd 11333 17 felt feel VBD cord-010119-t1x9gknd 11333 18 prepared prepared JJ cord-010119-t1x9gknd 11333 19 for for IN cord-010119-t1x9gknd 11333 20 any any DT cord-010119-t1x9gknd 11333 21 future future JJ cord-010119-t1x9gknd 11333 22 events event NNS cord-010119-t1x9gknd 11333 23 . . . cord-010119-t1x9gknd 11334 1 Results/ Results/ . cord-010119-t1x9gknd 11335 1 Finding finding NN cord-010119-t1x9gknd 11335 2 : : : cord-010119-t1x9gknd 11335 3 On on IN cord-010119-t1x9gknd 11335 4 November November NNP cord-010119-t1x9gknd 11335 5 11 11 CD cord-010119-t1x9gknd 11335 6 , , , cord-010119-t1x9gknd 11335 7 2016 2016 CD cord-010119-t1x9gknd 11335 8 , , , cord-010119-t1x9gknd 11335 9 the the DT cord-010119-t1x9gknd 11335 10 131 131 CD cord-010119-t1x9gknd 11335 11 RQS RQS NNP cord-010119-t1x9gknd 11335 12 was be VBD cord-010119-t1x9gknd 11335 13 deployed deploy VBN cord-010119-t1x9gknd 11335 14 to to IN cord-010119-t1x9gknd 11335 15 a a DT cord-010119-t1x9gknd 11335 16 civilian civilian JJ cord-010119-t1x9gknd 11335 17 aeromedical aeromedical JJ cord-010119-t1x9gknd 11335 18 evacuation evacuation NN cord-010119-t1x9gknd 11335 19 . . . cord-010119-t1x9gknd 11336 1 We -PRON- PRP cord-010119-t1x9gknd 11336 2 anticipated anticipate VBD cord-010119-t1x9gknd 11336 3 a a DT cord-010119-t1x9gknd 11336 4 6 6 CD cord-010119-t1x9gknd 11336 5 RBC RBC NNP cord-010119-t1x9gknd 11336 6 order order NN cord-010119-t1x9gknd 11336 7 . . . cord-010119-t1x9gknd 11337 1 The the DT cord-010119-t1x9gknd 11337 2 actual actual JJ cord-010119-t1x9gknd 11337 3 order order NN cord-010119-t1x9gknd 11337 4 was be VBD cord-010119-t1x9gknd 11337 5 7 7 CD cord-010119-t1x9gknd 11337 6 RBCs rbc NNS cord-010119-t1x9gknd 11337 7 and and CC cord-010119-t1x9gknd 11337 8 4 4 CD cord-010119-t1x9gknd 11337 9 FFP FFP NNP cord-010119-t1x9gknd 11337 10 . . . cord-010119-t1x9gknd 11338 1 Staff staff NN cord-010119-t1x9gknd 11338 2 was be VBD cord-010119-t1x9gknd 11338 3 preparing prepare VBG cord-010119-t1x9gknd 11338 4 frozen frozen JJ cord-010119-t1x9gknd 11338 5 FFP FFP NNP cord-010119-t1x9gknd 11338 6 to to TO cord-010119-t1x9gknd 11338 7 ship ship NN cord-010119-t1x9gknd 11338 8 , , , cord-010119-t1x9gknd 11338 9 as as IN cord-010119-t1x9gknd 11338 10 was be VBD cord-010119-t1x9gknd 11338 11 their -PRON- PRP$ cord-010119-t1x9gknd 11338 12 norm norm NN cord-010119-t1x9gknd 11338 13 for for IN cord-010119-t1x9gknd 11338 14 filling fill VBG cord-010119-t1x9gknd 11338 15 hospital hospital NN cord-010119-t1x9gknd 11338 16 orders order NNS cord-010119-t1x9gknd 11338 17 . . . cord-010119-t1x9gknd 11339 1 Realizing realize VBG cord-010119-t1x9gknd 11339 2 that that IN cord-010119-t1x9gknd 11339 3 they -PRON- PRP cord-010119-t1x9gknd 11339 4 could could MD cord-010119-t1x9gknd 11339 5 not not RB cord-010119-t1x9gknd 11339 6 thaw thaw VB cord-010119-t1x9gknd 11339 7 plasma plasma NN cord-010119-t1x9gknd 11339 8 in in IN cord-010119-t1x9gknd 11339 9 flight flight NN cord-010119-t1x9gknd 11339 10 , , , cord-010119-t1x9gknd 11339 11 we -PRON- PRP cord-010119-t1x9gknd 11339 12 contacted contact VBD cord-010119-t1x9gknd 11339 13 the the DT cord-010119-t1x9gknd 11339 14 131 131 CD cord-010119-t1x9gknd 11339 15 RQS RQS NNP cord-010119-t1x9gknd 11339 16 and and CC cord-010119-t1x9gknd 11339 17 offered offer VBD cord-010119-t1x9gknd 11339 18 Liquid Liquid NNP cord-010119-t1x9gknd 11339 19 Plasma Plasma NNP cord-010119-t1x9gknd 11339 20 instead instead RB cord-010119-t1x9gknd 11339 21 , , , cord-010119-t1x9gknd 11339 22 which which WDT cord-010119-t1x9gknd 11339 23 they -PRON- PRP cord-010119-t1x9gknd 11339 24 accepted accept VBD cord-010119-t1x9gknd 11339 25 . . . cord-010119-t1x9gknd 11340 1 Product product NN cord-010119-t1x9gknd 11340 2 was be VBD cord-010119-t1x9gknd 11340 3 consigned consign VBN cord-010119-t1x9gknd 11340 4 and and CC cord-010119-t1x9gknd 11340 5 picked pick VBN cord-010119-t1x9gknd 11340 6 up up RP cord-010119-t1x9gknd 11340 7 at at IN cord-010119-t1x9gknd 11340 8 4:30am 4:30am CD cord-010119-t1x9gknd 11340 9 by by IN cord-010119-t1x9gknd 11340 10 the the DT cord-010119-t1x9gknd 11340 11 131 131 CD cord-010119-t1x9gknd 11340 12 RQS RQS NNP cord-010119-t1x9gknd 11340 13 . . . cord-010119-t1x9gknd 11341 1 The the DT cord-010119-t1x9gknd 11341 2 patient patient NN cord-010119-t1x9gknd 11341 3 was be VBD cord-010119-t1x9gknd 11341 4 transfused transfuse VBN cord-010119-t1x9gknd 11341 5 in in IN cord-010119-t1x9gknd 11341 6 the the DT cord-010119-t1x9gknd 11341 7 field field NN cord-010119-t1x9gknd 11341 8 and and CC cord-010119-t1x9gknd 11341 9 then then RB cord-010119-t1x9gknd 11341 10 taken take VBN cord-010119-t1x9gknd 11341 11 to to IN cord-010119-t1x9gknd 11341 12 a a DT cord-010119-t1x9gknd 11341 13 nearby nearby JJ cord-010119-t1x9gknd 11341 14 hospital hospital NN cord-010119-t1x9gknd 11341 15 . . . cord-010119-t1x9gknd 11342 1 At at IN cord-010119-t1x9gknd 11342 2 our -PRON- PRP$ cord-010119-t1x9gknd 11342 3 joint joint JJ cord-010119-t1x9gknd 11342 4 debriefing debriefing NN cord-010119-t1x9gknd 11342 5 on on IN cord-010119-t1x9gknd 11342 6 November November NNP cord-010119-t1x9gknd 11342 7 28 28 CD cord-010119-t1x9gknd 11342 8 th th XX cord-010119-t1x9gknd 11342 9 , , , cord-010119-t1x9gknd 11342 10 we -PRON- PRP cord-010119-t1x9gknd 11342 11 established establish VBD cord-010119-t1x9gknd 11342 12 a a DT cord-010119-t1x9gknd 11342 13 maximum maximum JJ cord-010119-t1x9gknd 11342 14 blood blood NN cord-010119-t1x9gknd 11342 15 order order NN cord-010119-t1x9gknd 11342 16 of of IN cord-010119-t1x9gknd 11342 17 10 10 CD cord-010119-t1x9gknd 11342 18 RBC RBC NNP cord-010119-t1x9gknd 11342 19 and and CC cord-010119-t1x9gknd 11342 20 4 4 CD cord-010119-t1x9gknd 11342 21 Liquid Liquid NNP cord-010119-t1x9gknd 11342 22 Plasma Plasma NNP cord-010119-t1x9gknd 11342 23 , , , cord-010119-t1x9gknd 11342 24 noting note VBG cord-010119-t1x9gknd 11342 25 future future JJ cord-010119-t1x9gknd 11342 26 orders order NNS cord-010119-t1x9gknd 11342 27 may may MD cord-010119-t1x9gknd 11342 28 request request VB cord-010119-t1x9gknd 11342 29 fewer few JJR cord-010119-t1x9gknd 11342 30 products product NNS cord-010119-t1x9gknd 11342 31 , , , cord-010119-t1x9gknd 11342 32 yet yet CC cord-010119-t1x9gknd 11342 33 meet meet VB cord-010119-t1x9gknd 11342 34 the the DT cord-010119-t1x9gknd 11342 35 preferred preferred JJ cord-010119-t1x9gknd 11342 36 2 2 CD cord-010119-t1x9gknd 11342 37 RBC RBC NNP cord-010119-t1x9gknd 11342 38 ; ; : cord-010119-t1x9gknd 11342 39 1 1 CD cord-010119-t1x9gknd 11342 40 Plasma plasma NN cord-010119-t1x9gknd 11342 41 transfusion transfusion NN cord-010119-t1x9gknd 11342 42 ratio ratio NN cord-010119-t1x9gknd 11342 43 . . . cord-010119-t1x9gknd 11343 1 Conclusion conclusion NN cord-010119-t1x9gknd 11343 2 : : : cord-010119-t1x9gknd 11344 1 Military military JJ cord-010119-t1x9gknd 11344 2 personnel personnel NNS cord-010119-t1x9gknd 11344 3 are be VBP cord-010119-t1x9gknd 11344 4 adapted adapt VBN cord-010119-t1x9gknd 11344 5 to to TO cord-010119-t1x9gknd 11344 6 instantly instantly RB cord-010119-t1x9gknd 11344 7 adjust adjust VB cord-010119-t1x9gknd 11344 8 to to IN cord-010119-t1x9gknd 11344 9 an an DT cord-010119-t1x9gknd 11344 10 ever ever RB cord-010119-t1x9gknd 11344 11 changing change VBG cord-010119-t1x9gknd 11344 12 environment environment NN cord-010119-t1x9gknd 11344 13 . . . cord-010119-t1x9gknd 11345 1 Regulated regulate VBN cord-010119-t1x9gknd 11345 2 blood blood NN cord-010119-t1x9gknd 11345 3 centers center NNS cord-010119-t1x9gknd 11345 4 are be VBP cord-010119-t1x9gknd 11345 5 not not RB cord-010119-t1x9gknd 11345 6 as as RB cord-010119-t1x9gknd 11345 7 adaptable adaptable JJ cord-010119-t1x9gknd 11345 8 . . . cord-010119-t1x9gknd 11346 1 With with IN cord-010119-t1x9gknd 11346 2 clear clear JJ cord-010119-t1x9gknd 11346 3 and and CC cord-010119-t1x9gknd 11346 4 comprehensive comprehensive JJ cord-010119-t1x9gknd 11346 5 communication communication NN cord-010119-t1x9gknd 11346 6 and and CC cord-010119-t1x9gknd 11346 7 anticipation anticipation NN cord-010119-t1x9gknd 11346 8 on on IN cord-010119-t1x9gknd 11346 9 the the DT cord-010119-t1x9gknd 11346 10 blood blood NN cord-010119-t1x9gknd 11346 11 center center NN cord-010119-t1x9gknd 11346 12 's 's POS cord-010119-t1x9gknd 11346 13 part part NN cord-010119-t1x9gknd 11346 14 , , , cord-010119-t1x9gknd 11346 15 we -PRON- PRP cord-010119-t1x9gknd 11346 16 now now RB cord-010119-t1x9gknd 11346 17 supply supply VBP cord-010119-t1x9gknd 11346 18 civilian civilian JJ cord-010119-t1x9gknd 11346 19 blood blood NN cord-010119-t1x9gknd 11346 20 products product NNS cord-010119-t1x9gknd 11346 21 to to IN cord-010119-t1x9gknd 11346 22 the the DT cord-010119-t1x9gknd 11346 23 Air Air NNP cord-010119-t1x9gknd 11346 24 National National NNP cord-010119-t1x9gknd 11346 25 Guard Guard NNP cord-010119-t1x9gknd 11346 26 . . . cord-010119-t1x9gknd 11347 1 ( ( -LRB- cord-010119-t1x9gknd 11347 2 Table table NN cord-010119-t1x9gknd 11347 3 1 1 CD cord-010119-t1x9gknd 11347 4 ) ) -RRB- cord-010119-t1x9gknd 11347 5 . . . cord-010119-t1x9gknd 11348 1 The the DT cord-010119-t1x9gknd 11348 2 highest high JJS cord-010119-t1x9gknd 11348 3 mean mean JJ cord-010119-t1x9gknd 11348 4 Fib fib NN cord-010119-t1x9gknd 11348 5 concentration concentration NN cord-010119-t1x9gknd 11348 6 was be VBD cord-010119-t1x9gknd 11348 7 535 535 CD cord-010119-t1x9gknd 11348 8 mg mg NN cord-010119-t1x9gknd 11348 9 / / SYM cord-010119-t1x9gknd 11348 10 donor donor NN cord-010119-t1x9gknd 11348 11 unit unit NN cord-010119-t1x9gknd 11348 12 ; ; : cord-010119-t1x9gknd 11348 13 lowest low JJS cord-010119-t1x9gknd 11348 14 mean mean JJ cord-010119-t1x9gknd 11348 15 Fib Fib NNP cord-010119-t1x9gknd 11348 16 concentration concentration NN cord-010119-t1x9gknd 11348 17 was be VBD cord-010119-t1x9gknd 11348 18 264 264 CD cord-010119-t1x9gknd 11348 19 mg mg NNP cord-010119-t1x9gknd 11348 20 / / SYM cord-010119-t1x9gknd 11348 21 donor donor NN cord-010119-t1x9gknd 11348 22 unit unit NN cord-010119-t1x9gknd 11348 23 . . . cord-010119-t1x9gknd 11349 1 All all DT cord-010119-t1x9gknd 11349 2 sites site NNS cord-010119-t1x9gknd 11349 3 had have VBD cord-010119-t1x9gknd 11349 4 a a DT cord-010119-t1x9gknd 11349 5 mean mean JJ cord-010119-t1x9gknd 11349 6 Fib fib NN cord-010119-t1x9gknd 11349 7 concentration concentration NN cord-010119-t1x9gknd 11349 8 at at IN cord-010119-t1x9gknd 11349 9 least least JJS cord-010119-t1x9gknd 11349 10 100 100 CD cord-010119-t1x9gknd 11349 11 mg mg NNP cord-010119-t1x9gknd 11349 12 / / SYM cord-010119-t1x9gknd 11349 13 donor donor NN cord-010119-t1x9gknd 11349 14 unit unit NN cord-010119-t1x9gknd 11349 15 above above IN cord-010119-t1x9gknd 11349 16 the the DT cord-010119-t1x9gknd 11349 17 FDA FDA NNP cord-010119-t1x9gknd 11349 18 minimum minimum NN cord-010119-t1x9gknd 11349 19 requirement requirement NN cord-010119-t1x9gknd 11349 20 of of IN cord-010119-t1x9gknd 11349 21 150 150 CD cord-010119-t1x9gknd 11349 22 mg mg NNP cord-010119-t1x9gknd 11349 23 / / SYM cord-010119-t1x9gknd 11349 24 donor donor NN cord-010119-t1x9gknd 11349 25 unit unit NN cord-010119-t1x9gknd 11349 26 . . . cord-010119-t1x9gknd 11350 1 Fifteen fifteen CD cord-010119-t1x9gknd 11350 2 of of IN cord-010119-t1x9gknd 11350 3 17 17 CD cord-010119-t1x9gknd 11350 4 blood blood NN cord-010119-t1x9gknd 11350 5 centers center NNS cord-010119-t1x9gknd 11350 6 completed complete VBD cord-010119-t1x9gknd 11350 7 the the DT cord-010119-t1x9gknd 11350 8 manufacturing manufacturing NN cord-010119-t1x9gknd 11350 9 process process NN cord-010119-t1x9gknd 11350 10 survey survey NN cord-010119-t1x9gknd 11350 11 . . . cord-010119-t1x9gknd 11351 1 One one CD cord-010119-t1x9gknd 11351 2 used use VBD cord-010119-t1x9gknd 11351 3 a a DT cord-010119-t1x9gknd 11351 4 leukocyte leukocyte NN cord-010119-t1x9gknd 11351 5 reduction reduction NN cord-010119-t1x9gknd 11351 6 filter filter NN cord-010119-t1x9gknd 11351 7 with with IN cord-010119-t1x9gknd 11351 8 AHF AHF NNP cord-010119-t1x9gknd 11351 9 destined destine VBD cord-010119-t1x9gknd 11351 10 plasma plasma NN cord-010119-t1x9gknd 11351 11 . . . cord-010119-t1x9gknd 11352 1 All all DT cord-010119-t1x9gknd 11352 2 blood blood NN cord-010119-t1x9gknd 11352 3 centers center NNS cord-010119-t1x9gknd 11352 4 manufactured manufacture VBD cord-010119-t1x9gknd 11352 5 single single JJ cord-010119-t1x9gknd 11352 6 donor donor NN cord-010119-t1x9gknd 11352 7 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 11352 8 ; ; : cord-010119-t1x9gknd 11352 9 12 12 CD cord-010119-t1x9gknd 11352 10 manufactured manufactured JJ cord-010119-t1x9gknd 11352 11 pooled pool VBN cord-010119-t1x9gknd 11352 12 donor donor NN cord-010119-t1x9gknd 11352 13 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 11352 14 . . . cord-010119-t1x9gknd 11353 1 Most Most JJS cord-010119-t1x9gknd 11353 2 froze freeze VBD cord-010119-t1x9gknd 11353 3 plasma plasma NN cord-010119-t1x9gknd 11353 4 in in IN cord-010119-t1x9gknd 11353 5 a a DT cord-010119-t1x9gknd 11353 6 -188C -188c NN cord-010119-t1x9gknd 11353 7 or or CC cord-010119-t1x9gknd 11353 8 colder cold JJR cord-010119-t1x9gknd 11353 9 blood blood NN cord-010119-t1x9gknd 11353 10 bank bank NN cord-010119-t1x9gknd 11353 11 freezer freezer NN cord-010119-t1x9gknd 11353 12 . . . cord-010119-t1x9gknd 11354 1 One one CD cord-010119-t1x9gknd 11354 2 froze freeze VBD cord-010119-t1x9gknd 11354 3 plasma plasma NN cord-010119-t1x9gknd 11354 4 using use VBG cord-010119-t1x9gknd 11354 5 dry dry JJ cord-010119-t1x9gknd 11354 6 ice ice NN cord-010119-t1x9gknd 11354 7 , , , cord-010119-t1x9gknd 11354 8 and and CC cord-010119-t1x9gknd 11354 9 one one CD cord-010119-t1x9gknd 11354 10 used use VBD cord-010119-t1x9gknd 11354 11 a a DT cord-010119-t1x9gknd 11354 12 blast blast NN cord-010119-t1x9gknd 11354 13 freezer freezer NN cord-010119-t1x9gknd 11354 14 . . . cord-010119-t1x9gknd 11355 1 Two two CD cord-010119-t1x9gknd 11355 2 blood blood NN cord-010119-t1x9gknd 11355 3 centers center NNS cord-010119-t1x9gknd 11355 4 method method NN cord-010119-t1x9gknd 11355 5 of of IN cord-010119-t1x9gknd 11355 6 thawing thaw VBG cord-010119-t1x9gknd 11355 7 frozen frozen JJ cord-010119-t1x9gknd 11355 8 plasma plasma NN cord-010119-t1x9gknd 11355 9 took take VBD cord-010119-t1x9gknd 11355 10 longer long JJR cord-010119-t1x9gknd 11355 11 than than IN cord-010119-t1x9gknd 11355 12 10 10 CD cord-010119-t1x9gknd 11355 13 hours hour NNS cord-010119-t1x9gknd 11355 14 . . . cord-010119-t1x9gknd 11356 1 Conclusion conclusion NN cord-010119-t1x9gknd 11356 2 : : : cord-010119-t1x9gknd 11356 3 Blood blood NN cord-010119-t1x9gknd 11356 4 centers center NNS cord-010119-t1x9gknd 11356 5 consistently consistently RB cord-010119-t1x9gknd 11356 6 met meet VBD cord-010119-t1x9gknd 11356 7 the the DT cord-010119-t1x9gknd 11356 8 overall overall JJ cord-010119-t1x9gknd 11356 9 Fib Fib NNP cord-010119-t1x9gknd 11356 10 minimum minimum NN cord-010119-t1x9gknd 11356 11 requirement requirement NN cord-010119-t1x9gknd 11356 12 with with IN cord-010119-t1x9gknd 11356 13 a a DT cord-010119-t1x9gknd 11356 14 mean mean NN cord-010119-t1x9gknd 11356 15 of of IN cord-010119-t1x9gknd 11356 16 345 345 CD cord-010119-t1x9gknd 11356 17 mg mg NNP cord-010119-t1x9gknd 11356 18 / / SYM cord-010119-t1x9gknd 11356 19 donor donor NN cord-010119-t1x9gknd 11356 20 unit unit NN cord-010119-t1x9gknd 11356 21 , , , cord-010119-t1x9gknd 11356 22 over over IN cord-010119-t1x9gknd 11356 23 double double PDT cord-010119-t1x9gknd 11356 24 the the DT cord-010119-t1x9gknd 11356 25 FDA FDA NNP cord-010119-t1x9gknd 11356 26 requirement requirement NN cord-010119-t1x9gknd 11356 27 . . . cord-010119-t1x9gknd 11357 1 However however RB cord-010119-t1x9gknd 11357 2 there there EX cord-010119-t1x9gknd 11357 3 is be VBZ cord-010119-t1x9gknd 11357 4 variability variability NN cord-010119-t1x9gknd 11357 5 in in IN cord-010119-t1x9gknd 11357 6 Fib Fib NNP cord-010119-t1x9gknd 11357 7 levels level NNS cord-010119-t1x9gknd 11357 8 amongst amongst IN cord-010119-t1x9gknd 11357 9 blood blood NN cord-010119-t1x9gknd 11357 10 centers center NNS cord-010119-t1x9gknd 11357 11 . . . cord-010119-t1x9gknd 11358 1 In in IN cord-010119-t1x9gknd 11358 2 general general JJ cord-010119-t1x9gknd 11358 3 , , , cord-010119-t1x9gknd 11358 4 manufacturing manufacturing NN cord-010119-t1x9gknd 11358 5 processes process NNS cord-010119-t1x9gknd 11358 6 were be VBD cord-010119-t1x9gknd 11358 7 similar similar JJ cord-010119-t1x9gknd 11358 8 with with IN cord-010119-t1x9gknd 11358 9 a a DT cord-010119-t1x9gknd 11358 10 few few JJ cord-010119-t1x9gknd 11358 11 exceptions exception NNS cord-010119-t1x9gknd 11358 12 . . . cord-010119-t1x9gknd 11359 1 Blood blood NN cord-010119-t1x9gknd 11359 2 centers center NNS cord-010119-t1x9gknd 11359 3 should should MD cord-010119-t1x9gknd 11359 4 inform inform VB cord-010119-t1x9gknd 11359 5 their -PRON- PRP$ cord-010119-t1x9gknd 11359 6 hospital hospital NN cord-010119-t1x9gknd 11359 7 customers customer NNS cord-010119-t1x9gknd 11359 8 of of IN cord-010119-t1x9gknd 11359 9 their -PRON- PRP$ cord-010119-t1x9gknd 11359 10 average average JJ cord-010119-t1x9gknd 11359 11 Fib Fib NNP cord-010119-t1x9gknd 11359 12 level level NN cord-010119-t1x9gknd 11359 13 in in IN cord-010119-t1x9gknd 11359 14 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 11359 15 in in IN cord-010119-t1x9gknd 11359 16 order order NN cord-010119-t1x9gknd 11359 17 to to IN cord-010119-t1x9gknd 11359 18 most most RBS cord-010119-t1x9gknd 11359 19 appropriately appropriately RB cord-010119-t1x9gknd 11359 20 care care VB cord-010119-t1x9gknd 11359 21 for for IN cord-010119-t1x9gknd 11359 22 patients patient NNS cord-010119-t1x9gknd 11359 23 receiving receive VBG cord-010119-t1x9gknd 11359 24 this this DT cord-010119-t1x9gknd 11359 25 product product NN cord-010119-t1x9gknd 11359 26 . . . cord-010119-t1x9gknd 11360 1 Compliance Compliance NNP cord-010119-t1x9gknd 11360 2 & & CC cord-010119-t1x9gknd 11360 3 Productivity Productivity NNP cord-010119-t1x9gknd 11360 4 Improvement Improvement NNP cord-010119-t1x9gknd 11361 1 Via via IN cord-010119-t1x9gknd 11361 2 Engineered engineer VBN cord-010119-t1x9gknd 11361 3 - - HYPH cord-010119-t1x9gknd 11361 4 Staffing/ Staffing/ NNP cord-010119-t1x9gknd 11361 5 Scheduling Scheduling NNP cord-010119-t1x9gknd 11361 6 Calculator Calculator NNP cord-010119-t1x9gknd 11361 7 Application Application NNP cord-010119-t1x9gknd 11361 8 ( ( -LRB- cord-010119-t1x9gknd 11361 9 APP app NN cord-010119-t1x9gknd 11361 10 ) ) -RRB- cord-010119-t1x9gknd 11361 11 Mary Mary NNP cord-010119-t1x9gknd 11361 12 Deck Deck NNP cord-010119-t1x9gknd 11361 13 , , , cord-010119-t1x9gknd 11361 14 Mark Mark NNP cord-010119-t1x9gknd 11361 15 Angelelli Angelelli NNP cord-010119-t1x9gknd 11361 16 and and CC cord-010119-t1x9gknd 11361 17 Kevin Kevin NNP cord-010119-t1x9gknd 11361 18 Lee Lee NNP cord-010119-t1x9gknd 11362 1 * * NFP cord-010119-t1x9gknd 11362 2 . . . cord-010119-t1x9gknd 11363 1 American American NNP cord-010119-t1x9gknd 11363 2 Red Red NNP cord-010119-t1x9gknd 11363 3 Cross Cross NNP cord-010119-t1x9gknd 11363 4 Background Background NNP cord-010119-t1x9gknd 11363 5 / / SYM cord-010119-t1x9gknd 11363 6 Case Case NNP cord-010119-t1x9gknd 11363 7 Studies Studies NNPS cord-010119-t1x9gknd 11363 8 : : : cord-010119-t1x9gknd 11364 1 The the DT cord-010119-t1x9gknd 11364 2 healthcare healthcare NN cord-010119-t1x9gknd 11364 3 industry industry NN cord-010119-t1x9gknd 11364 4 , , , cord-010119-t1x9gknd 11364 5 particularly particularly RB cord-010119-t1x9gknd 11364 6 the the DT cord-010119-t1x9gknd 11364 7 blood blood NN cord-010119-t1x9gknd 11364 8 banking banking NN cord-010119-t1x9gknd 11364 9 industry industry NN cord-010119-t1x9gknd 11364 10 continues continue VBZ cord-010119-t1x9gknd 11364 11 to to TO cord-010119-t1x9gknd 11364 12 experience experience VB cord-010119-t1x9gknd 11364 13 tremendous tremendous JJ cord-010119-t1x9gknd 11364 14 pressures pressure NNS cord-010119-t1x9gknd 11364 15 not not RB cord-010119-t1x9gknd 11364 16 only only RB cord-010119-t1x9gknd 11364 17 with with IN cord-010119-t1x9gknd 11364 18 ensuring ensure VBG cord-010119-t1x9gknd 11364 19 patient patient JJ cord-010119-t1x9gknd 11364 20 safety safety NN cord-010119-t1x9gknd 11364 21 and and CC cord-010119-t1x9gknd 11364 22 quality quality NN cord-010119-t1x9gknd 11364 23 daily daily RB cord-010119-t1x9gknd 11364 24 , , , cord-010119-t1x9gknd 11364 25 but but CC cord-010119-t1x9gknd 11364 26 managing manage VBG cord-010119-t1x9gknd 11364 27 and and CC cord-010119-t1x9gknd 11364 28 maintaining maintain VBG cord-010119-t1x9gknd 11364 29 an an DT cord-010119-t1x9gknd 11364 30 efficient efficient JJ cord-010119-t1x9gknd 11364 31 operation operation NN cord-010119-t1x9gknd 11364 32 with with IN cord-010119-t1x9gknd 11364 33 a a DT cord-010119-t1x9gknd 11364 34 cost cost NN cord-010119-t1x9gknd 11364 35 competitive competitive JJ cord-010119-t1x9gknd 11364 36 structure structure NN cord-010119-t1x9gknd 11364 37 . . . cord-010119-t1x9gknd 11365 1 Applications application NNS cord-010119-t1x9gknd 11365 2 of of IN cord-010119-t1x9gknd 11365 3 basic basic JJ cord-010119-t1x9gknd 11365 4 Industrial Industrial NNP cord-010119-t1x9gknd 11365 5 Engineering Engineering NNP cord-010119-t1x9gknd 11365 6 tools tool NNS cord-010119-t1x9gknd 11365 7 , , , cord-010119-t1x9gknd 11365 8 coupled couple VBN cord-010119-t1x9gknd 11365 9 with with IN cord-010119-t1x9gknd 11365 10 Lean Lean NNP cord-010119-t1x9gknd 11365 11 - - HYPH cord-010119-t1x9gknd 11365 12 Six six CD cord-010119-t1x9gknd 11365 13 Sigma Sigma NNP cord-010119-t1x9gknd 11365 14 techniques technique NNS cord-010119-t1x9gknd 11365 15 such such JJ cord-010119-t1x9gknd 11365 16 as as IN cord-010119-t1x9gknd 11365 17 time time NN cord-010119-t1x9gknd 11365 18 study study NN cord-010119-t1x9gknd 11365 19 analysis analysis NN cord-010119-t1x9gknd 11365 20 , , , cord-010119-t1x9gknd 11365 21 bottleneck bottleneck NN cord-010119-t1x9gknd 11365 22 elimination elimination NN cord-010119-t1x9gknd 11365 23 & & CC cord-010119-t1x9gknd 11365 24 process process NN cord-010119-t1x9gknd 11365 25 standardization standardization NN cord-010119-t1x9gknd 11365 26 to to IN cord-010119-t1x9gknd 11365 27 _SP cord-010119-t1x9gknd 11365 28 TRANSFUSION transfusion NN cord-010119-t1x9gknd 11365 29 reduce reduce VB cord-010119-t1x9gknd 11365 30 variation variation NN cord-010119-t1x9gknd 11365 31 has have VBZ cord-010119-t1x9gknd 11365 32 been be VBN cord-010119-t1x9gknd 11365 33 transformed transform VBN cord-010119-t1x9gknd 11365 34 into into IN cord-010119-t1x9gknd 11365 35 an an DT cord-010119-t1x9gknd 11365 36 Application Application NNP cord-010119-t1x9gknd 11365 37 ( ( -LRB- cord-010119-t1x9gknd 11365 38 for for IN cord-010119-t1x9gknd 11365 39 short short JJ cord-010119-t1x9gknd 11365 40 " " `` cord-010119-t1x9gknd 11365 41 APP app NN cord-010119-t1x9gknd 11365 42 " " '' cord-010119-t1x9gknd 11365 43 ) ) -RRB- cord-010119-t1x9gknd 11365 44 , , , cord-010119-t1x9gknd 11365 45 which which WDT cord-010119-t1x9gknd 11365 46 can can MD cord-010119-t1x9gknd 11365 47 be be VB cord-010119-t1x9gknd 11365 48 utilized utilize VBN cord-010119-t1x9gknd 11365 49 to to TO cord-010119-t1x9gknd 11365 50 determine determine VB cord-010119-t1x9gknd 11365 51 process process NN cord-010119-t1x9gknd 11365 52 and and CC cord-010119-t1x9gknd 11365 53 staffing staffing NN cord-010119-t1x9gknd 11365 54 optimization optimization NN cord-010119-t1x9gknd 11365 55 and and CC cord-010119-t1x9gknd 11365 56 provide provide VB cord-010119-t1x9gknd 11365 57 flexibility flexibility NN cord-010119-t1x9gknd 11365 58 to to IN cord-010119-t1x9gknd 11365 59 the the DT cord-010119-t1x9gknd 11365 60 dynamic dynamic JJ cord-010119-t1x9gknd 11365 61 nature nature NN cord-010119-t1x9gknd 11365 62 of of IN cord-010119-t1x9gknd 11365 63 changing change VBG cord-010119-t1x9gknd 11365 64 needs need NNS cord-010119-t1x9gknd 11365 65 in in IN cord-010119-t1x9gknd 11365 66 blood blood NN cord-010119-t1x9gknd 11365 67 banking banking NN cord-010119-t1x9gknd 11365 68 . . . cord-010119-t1x9gknd 11366 1 Study Study NNP cord-010119-t1x9gknd 11366 2 Design Design NNP cord-010119-t1x9gknd 11366 3 / / SYM cord-010119-t1x9gknd 11366 4 Methods method NNS cord-010119-t1x9gknd 11366 5 : : : cord-010119-t1x9gknd 11366 6 A a DT cord-010119-t1x9gknd 11366 7 time time NN cord-010119-t1x9gknd 11366 8 study study NN cord-010119-t1x9gknd 11366 9 analysis analysis NN cord-010119-t1x9gknd 11366 10 offers offer VBZ cord-010119-t1x9gknd 11366 11 valuable valuable JJ cord-010119-t1x9gknd 11366 12 data datum NNS cord-010119-t1x9gknd 11366 13 about about IN cord-010119-t1x9gknd 11366 14 the the DT cord-010119-t1x9gknd 11366 15 process process NN cord-010119-t1x9gknd 11366 16 requirements requirement NNS cord-010119-t1x9gknd 11366 17 . . . cord-010119-t1x9gknd 11367 1 Once once IN cord-010119-t1x9gknd 11367 2 this this DT cord-010119-t1x9gknd 11367 3 baseline baseline NN cord-010119-t1x9gknd 11367 4 has have VBZ cord-010119-t1x9gknd 11367 5 been be VBN cord-010119-t1x9gknd 11367 6 established establish VBN cord-010119-t1x9gknd 11367 7 , , , cord-010119-t1x9gknd 11367 8 translating translate VBG cord-010119-t1x9gknd 11367 9 the the DT cord-010119-t1x9gknd 11367 10 data datum NNS cord-010119-t1x9gknd 11367 11 into into IN cord-010119-t1x9gknd 11367 12 a a DT cord-010119-t1x9gknd 11367 13 user user NN cord-010119-t1x9gknd 11367 14 - - HYPH cord-010119-t1x9gknd 11367 15 friendly friendly JJ cord-010119-t1x9gknd 11367 16 APP app NN cord-010119-t1x9gknd 11367 17 would would MD cord-010119-t1x9gknd 11367 18 enable enable VB cord-010119-t1x9gknd 11367 19 ease ease NN cord-010119-t1x9gknd 11367 20 and and CC cord-010119-t1x9gknd 11367 21 practical practical JJ cord-010119-t1x9gknd 11367 22 use use NN cord-010119-t1x9gknd 11367 23 to to TO cord-010119-t1x9gknd 11367 24 facilitate facilitate VB cord-010119-t1x9gknd 11367 25 business business NN cord-010119-t1x9gknd 11367 26 decision decision NN cord-010119-t1x9gknd 11367 27 - - HYPH cord-010119-t1x9gknd 11367 28 making making NN cord-010119-t1x9gknd 11367 29 as as RB cord-010119-t1x9gknd 11367 30 well well RB cord-010119-t1x9gknd 11367 31 as as IN cord-010119-t1x9gknd 11367 32 effectively effectively RB cord-010119-t1x9gknd 11367 33 manage manage VBP cord-010119-t1x9gknd 11367 34 daily daily JJ cord-010119-t1x9gknd 11367 35 operations operation NNS cord-010119-t1x9gknd 11367 36 . . . cord-010119-t1x9gknd 11368 1 Important important JJ cord-010119-t1x9gknd 11368 2 concepts concept NNS cord-010119-t1x9gknd 11368 3 such such JJ cord-010119-t1x9gknd 11368 4 as as IN cord-010119-t1x9gknd 11369 1 Lean lean JJ cord-010119-t1x9gknd 11369 2 - - HYPH cord-010119-t1x9gknd 11369 3 Pull pull NN cord-010119-t1x9gknd 11369 4 Production production NN cord-010119-t1x9gknd 11369 5 System system NN cord-010119-t1x9gknd 11369 6 , , , cord-010119-t1x9gknd 11369 7 bottleneck bottleneck NN cord-010119-t1x9gknd 11369 8 elimination elimination NN cord-010119-t1x9gknd 11369 9 , , , cord-010119-t1x9gknd 11370 1 work work NN cord-010119-t1x9gknd 11370 2 - - HYPH cord-010119-t1x9gknd 11370 3 load load NN cord-010119-t1x9gknd 11370 4 balancing balancing NN cord-010119-t1x9gknd 11370 5 together together RB cord-010119-t1x9gknd 11370 6 with with IN cord-010119-t1x9gknd 11370 7 basic basic JJ cord-010119-t1x9gknd 11370 8 development development NN cord-010119-t1x9gknd 11370 9 of of IN cord-010119-t1x9gknd 11370 10 the the DT cord-010119-t1x9gknd 11370 11 APP app NN cord-010119-t1x9gknd 11370 12 using use VBG cord-010119-t1x9gknd 11370 13 MS MS NNP cord-010119-t1x9gknd 11370 14 Excel Excel NNP cord-010119-t1x9gknd 11370 15 software software NN cord-010119-t1x9gknd 11370 16 will will MD cord-010119-t1x9gknd 11370 17 be be VB cord-010119-t1x9gknd 11370 18 demonstrated demonstrate VBN cord-010119-t1x9gknd 11370 19 . . . cord-010119-t1x9gknd 11371 1 Results result NNS cord-010119-t1x9gknd 11371 2 / / SYM cord-010119-t1x9gknd 11371 3 Findings finding NNS cord-010119-t1x9gknd 11371 4 : : : cord-010119-t1x9gknd 11371 5 Successful successful JJ cord-010119-t1x9gknd 11371 6 rollouts rollout NNS cord-010119-t1x9gknd 11371 7 and and CC cord-010119-t1x9gknd 11371 8 implementations implementation NNS cord-010119-t1x9gknd 11371 9 of of IN cord-010119-t1x9gknd 11371 10 the the DT cord-010119-t1x9gknd 11371 11 Staffing/ Staffing/ NNP cord-010119-t1x9gknd 11371 12 Scheduling Scheduling NNP cord-010119-t1x9gknd 11371 13 Calculator Calculator NNP cord-010119-t1x9gknd 11371 14 APP app NN cord-010119-t1x9gknd 11371 15 across across IN cord-010119-t1x9gknd 11371 16 pilot pilot NN cord-010119-t1x9gknd 11371 17 facilities facility NNS cord-010119-t1x9gknd 11371 18 , , , cord-010119-t1x9gknd 11371 19 then then RB cord-010119-t1x9gknd 11371 20 onto onto IN cord-010119-t1x9gknd 11371 21 facilities facility NNS cord-010119-t1x9gknd 11371 22 nationwide nationwide RB cord-010119-t1x9gknd 11371 23 , , , cord-010119-t1x9gknd 11371 24 has have VBZ cord-010119-t1x9gknd 11371 25 yielded yield VBN cord-010119-t1x9gknd 11371 26 improved improved JJ cord-010119-t1x9gknd 11371 27 productivity productivity NN cord-010119-t1x9gknd 11371 28 together together RB cord-010119-t1x9gknd 11371 29 with with IN cord-010119-t1x9gknd 11371 30 a a DT cord-010119-t1x9gknd 11371 31 sustainable sustainable JJ cord-010119-t1x9gknd 11371 32 compliance compliance NN cord-010119-t1x9gknd 11371 33 scorecard scorecard NN cord-010119-t1x9gknd 11371 34 . . . cord-010119-t1x9gknd 11372 1 The the DT cord-010119-t1x9gknd 11372 2 APP app NN cord-010119-t1x9gknd 11372 3 interactive interactive NN cord-010119-t1x9gknd 11372 4 - - HYPH cord-010119-t1x9gknd 11372 5 based base VBN cord-010119-t1x9gknd 11372 6 approach approach NN cord-010119-t1x9gknd 11372 7 , , , cord-010119-t1x9gknd 11372 8 programmed program VBN cord-010119-t1x9gknd 11372 9 via via IN cord-010119-t1x9gknd 11372 10 a a DT cord-010119-t1x9gknd 11372 11 commonly commonly RB cord-010119-t1x9gknd 11372 12 used use VBN cord-010119-t1x9gknd 11372 13 software software NN cord-010119-t1x9gknd 11372 14 , , , cord-010119-t1x9gknd 11372 15 MS MS NNP cord-010119-t1x9gknd 11372 16 Excel Excel NNP cord-010119-t1x9gknd 11372 17 , , , cord-010119-t1x9gknd 11372 18 was be VBD cord-010119-t1x9gknd 11372 19 used use VBN cord-010119-t1x9gknd 11372 20 to to TO cord-010119-t1x9gknd 11372 21 analyze analyze VB cord-010119-t1x9gknd 11372 22 how how WRB cord-010119-t1x9gknd 11372 23 to to TO cord-010119-t1x9gknd 11372 24 optimize optimize VB cord-010119-t1x9gknd 11372 25 staffing staffing NN cord-010119-t1x9gknd 11372 26 requirements requirement NNS cord-010119-t1x9gknd 11372 27 together together RB cord-010119-t1x9gknd 11372 28 with with IN cord-010119-t1x9gknd 11372 29 staff staff NN cord-010119-t1x9gknd 11372 30 - - HYPH cord-010119-t1x9gknd 11372 31 scheduling scheduling NN cord-010119-t1x9gknd 11372 32 ( ( -LRB- cord-010119-t1x9gknd 11372 33 i.e. i.e. FW cord-010119-t1x9gknd 11372 34 match match NN cord-010119-t1x9gknd 11372 35 incoming incoming JJ cord-010119-t1x9gknd 11372 36 volume volume NN cord-010119-t1x9gknd 11372 37 / / SYM cord-010119-t1x9gknd 11372 38 work work NN cord-010119-t1x9gknd 11372 39 content content NN cord-010119-t1x9gknd 11372 40 to to IN cord-010119-t1x9gknd 11372 41 staffing staff VBG cord-010119-t1x9gknd 11372 42 availability availability NN cord-010119-t1x9gknd 11372 43 ) ) -RRB- cord-010119-t1x9gknd 11372 44 . . . cord-010119-t1x9gknd 11373 1 The the DT cord-010119-t1x9gknd 11373 2 Staffing Staffing NNP cord-010119-t1x9gknd 11373 3 / / SYM cord-010119-t1x9gknd 11373 4 Scheduling Scheduling NNP cord-010119-t1x9gknd 11373 5 Calculator Calculator NNP cord-010119-t1x9gknd 11373 6 APP app NN cord-010119-t1x9gknd 11373 7 has have VBZ cord-010119-t1x9gknd 11373 8 been be VBN cord-010119-t1x9gknd 11373 9 utilized utilize VBN cord-010119-t1x9gknd 11373 10 by by IN cord-010119-t1x9gknd 11373 11 executives executive NNS cord-010119-t1x9gknd 11373 12 to to TO cord-010119-t1x9gknd 11373 13 evaluate evaluate VB cord-010119-t1x9gknd 11373 14 " " `` cord-010119-t1x9gknd 11373 15 what what WP cord-010119-t1x9gknd 11373 16 - - : cord-010119-t1x9gknd 11373 17 if if IN cord-010119-t1x9gknd 11373 18 " " `` cord-010119-t1x9gknd 11373 19 scenarios scenario NNS cord-010119-t1x9gknd 11373 20 ( ( -LRB- cord-010119-t1x9gknd 11373 21 sensitivity sensitivity NN cord-010119-t1x9gknd 11373 22 analysis analysis NN cord-010119-t1x9gknd 11373 23 ) ) -RRB- cord-010119-t1x9gknd 11373 24 as as RB cord-010119-t1x9gknd 11373 25 well well RB cord-010119-t1x9gknd 11373 26 as as IN cord-010119-t1x9gknd 11373 27 a a DT cord-010119-t1x9gknd 11373 28 planning planning NN cord-010119-t1x9gknd 11373 29 toolkit toolkit NN cord-010119-t1x9gknd 11373 30 to to TO cord-010119-t1x9gknd 11373 31 proactively proactively RB cord-010119-t1x9gknd 11373 32 manage manage VB cord-010119-t1x9gknd 11373 33 the the DT cord-010119-t1x9gknd 11373 34 changing change VBG cord-010119-t1x9gknd 11373 35 demands demand NNS cord-010119-t1x9gknd 11373 36 of of IN cord-010119-t1x9gknd 11373 37 blood blood NN cord-010119-t1x9gknd 11373 38 banking banking NN cord-010119-t1x9gknd 11373 39 . . . cord-010119-t1x9gknd 11374 1 Conclusion conclusion NN cord-010119-t1x9gknd 11374 2 : : : cord-010119-t1x9gknd 11375 1 Besides besides IN cord-010119-t1x9gknd 11375 2 providing provide VBG cord-010119-t1x9gknd 11375 3 a a DT cord-010119-t1x9gknd 11375 4 key key JJ cord-010119-t1x9gknd 11375 5 mechanism mechanism NN cord-010119-t1x9gknd 11375 6 for for IN cord-010119-t1x9gknd 11375 7 increased increase VBN cord-010119-t1x9gknd 11375 8 productivity productivity NN cord-010119-t1x9gknd 11375 9 and and CC cord-010119-t1x9gknd 11375 10 sustained sustained JJ cord-010119-t1x9gknd 11375 11 compliance compliance NN cord-010119-t1x9gknd 11375 12 -a -a HYPH cord-010119-t1x9gknd 11375 13 top top NN cord-010119-t1x9gknd 11375 14 priority priority NN cord-010119-t1x9gknd 11375 15 for for IN cord-010119-t1x9gknd 11375 16 blood blood NN cord-010119-t1x9gknd 11375 17 banks bank NNS cord-010119-t1x9gknd 11376 1 -the -the NFP cord-010119-t1x9gknd 11377 1 Staffing/ Staffing/ NNP cord-010119-t1x9gknd 11377 2 Scheduling Scheduling NNP cord-010119-t1x9gknd 11377 3 Calculator Calculator NNP cord-010119-t1x9gknd 11377 4 APP app NN cord-010119-t1x9gknd 11377 5 will will MD cord-010119-t1x9gknd 11377 6 highlight highlight VB cord-010119-t1x9gknd 11377 7 continuous continuous JJ cord-010119-t1x9gknd 11377 8 improvement improvement NN cord-010119-t1x9gknd 11377 9 opportunities opportunity NNS cord-010119-t1x9gknd 11377 10 and and CC cord-010119-t1x9gknd 11377 11 spring spring NN cord-010119-t1x9gknd 11377 12 - - HYPH cord-010119-t1x9gknd 11377 13 board board NN cord-010119-t1x9gknd 11377 14 to to IN cord-010119-t1x9gknd 11377 15 system system NN cord-010119-t1x9gknd 11377 16 - - HYPH cord-010119-t1x9gknd 11377 17 wide wide JJ cord-010119-t1x9gknd 11377 18 acceptance acceptance NN cord-010119-t1x9gknd 11377 19 and and CC cord-010119-t1x9gknd 11377 20 standardization standardization NN cord-010119-t1x9gknd 11377 21 . . . cord-010119-t1x9gknd 11378 1 All all DT cord-010119-t1x9gknd 11378 2 coolers cooler NNS cord-010119-t1x9gknd 11378 3 were be VBD cord-010119-t1x9gknd 11378 4 prepared prepare VBN cord-010119-t1x9gknd 11378 5 in in IN cord-010119-t1x9gknd 11378 6 a a DT cord-010119-t1x9gknd 11378 7 walk walk NN cord-010119-t1x9gknd 11378 8 - - HYPH cord-010119-t1x9gknd 11378 9 in in RP cord-010119-t1x9gknd 11378 10 refrigerator refrigerator NN cord-010119-t1x9gknd 11378 11 . . . cord-010119-t1x9gknd 11379 1 Two two CD cord-010119-t1x9gknd 11379 2 scoops scoop NNS cord-010119-t1x9gknd 11379 3 of of IN cord-010119-t1x9gknd 11379 4 wet wet JJ cord-010119-t1x9gknd 11379 5 ice ice NN cord-010119-t1x9gknd 11379 6 or or CC cord-010119-t1x9gknd 11379 7 two two CD cord-010119-t1x9gknd 11379 8 ice ice NN cord-010119-t1x9gknd 11379 9 packs pack NNS cord-010119-t1x9gknd 11379 10 were be VBD cord-010119-t1x9gknd 11379 11 placed place VBN cord-010119-t1x9gknd 11379 12 at at IN cord-010119-t1x9gknd 11379 13 the the DT cord-010119-t1x9gknd 11379 14 bottom bottom NN cord-010119-t1x9gknd 11379 15 of of IN cord-010119-t1x9gknd 11379 16 large large JJ cord-010119-t1x9gknd 11379 17 / / SYM cord-010119-t1x9gknd 11379 18 medium medium NN cord-010119-t1x9gknd 11379 19 or or CC cord-010119-t1x9gknd 11379 20 small small JJ cord-010119-t1x9gknd 11379 21 coolers cooler NNS cord-010119-t1x9gknd 11379 22 , , , cord-010119-t1x9gknd 11379 23 respectively respectively RB cord-010119-t1x9gknd 11379 24 , , , cord-010119-t1x9gknd 11379 25 with with IN cord-010119-t1x9gknd 11379 26 RBC RBC NNP cord-010119-t1x9gknd 11379 27 units unit NNS cord-010119-t1x9gknd 11379 28 on on IN cord-010119-t1x9gknd 11379 29 top top NN cord-010119-t1x9gknd 11379 30 of of IN cord-010119-t1x9gknd 11379 31 the the DT cord-010119-t1x9gknd 11379 32 ice ice NN cord-010119-t1x9gknd 11379 33 . . . cord-010119-t1x9gknd 11380 1 A a DT cord-010119-t1x9gknd 11380 2 quality quality NN cord-010119-t1x9gknd 11380 3 - - HYPH cord-010119-t1x9gknd 11380 4 controlled control VBN cord-010119-t1x9gknd 11380 5 thermometer thermometer NN cord-010119-t1x9gknd 11380 6 was be VBD cord-010119-t1x9gknd 11380 7 placed place VBN cord-010119-t1x9gknd 11380 8 on on IN cord-010119-t1x9gknd 11380 9 top top NN cord-010119-t1x9gknd 11380 10 of of IN cord-010119-t1x9gknd 11380 11 the the DT cord-010119-t1x9gknd 11380 12 RBC RBC NNP cord-010119-t1x9gknd 11380 13 units unit NNS cord-010119-t1x9gknd 11380 14 . . . cord-010119-t1x9gknd 11381 1 A a DT cord-010119-t1x9gknd 11381 2 control control NN cord-010119-t1x9gknd 11381 3 thermometer thermometer NN cord-010119-t1x9gknd 11381 4 was be VBD cord-010119-t1x9gknd 11381 5 place place NN cord-010119-t1x9gknd 11381 6 at at IN cord-010119-t1x9gknd 11381 7 the the DT cord-010119-t1x9gknd 11381 8 interface interface NN cord-010119-t1x9gknd 11381 9 between between IN cord-010119-t1x9gknd 11381 10 the the DT cord-010119-t1x9gknd 11381 11 ice ice NN cord-010119-t1x9gknd 11381 12 and and CC cord-010119-t1x9gknd 11381 13 the the DT cord-010119-t1x9gknd 11381 14 RBC RBC NNP cord-010119-t1x9gknd 11381 15 units unit NNS cord-010119-t1x9gknd 11381 16 in in IN cord-010119-t1x9gknd 11381 17 one one CD cord-010119-t1x9gknd 11381 18 large large JJ cord-010119-t1x9gknd 11381 19 and and CC cord-010119-t1x9gknd 11381 20 one one CD cord-010119-t1x9gknd 11381 21 medium medium JJ cord-010119-t1x9gknd 11381 22 cooler cooler NN cord-010119-t1x9gknd 11381 23 . . . cord-010119-t1x9gknd 11382 1 The the DT cord-010119-t1x9gknd 11382 2 start start NN cord-010119-t1x9gknd 11382 3 temperature temperature NN cord-010119-t1x9gknd 11382 4 was be VBD cord-010119-t1x9gknd 11382 5 recorded record VBN cord-010119-t1x9gknd 11382 6 and and CC cord-010119-t1x9gknd 11382 7 then then RB cord-010119-t1x9gknd 11382 8 the the DT cord-010119-t1x9gknd 11382 9 temperature temperature NN cord-010119-t1x9gknd 11382 10 was be VBD cord-010119-t1x9gknd 11382 11 recorded record VBN cord-010119-t1x9gknd 11382 12 every every DT cord-010119-t1x9gknd 11382 13 15 15 CD cord-010119-t1x9gknd 11382 14 minutes minute NNS cord-010119-t1x9gknd 11382 15 for for IN cord-010119-t1x9gknd 11382 16 a a DT cord-010119-t1x9gknd 11382 17 12 12 CD cord-010119-t1x9gknd 11382 18 hour hour NN cord-010119-t1x9gknd 11382 19 period period NN cord-010119-t1x9gknd 11382 20 or or CC cord-010119-t1x9gknd 11382 21 until until IN cord-010119-t1x9gknd 11382 22 the the DT cord-010119-t1x9gknd 11382 23 temperature temperature NN cord-010119-t1x9gknd 11382 24 exceeded exceed VBD cord-010119-t1x9gknd 11382 25 68C. 68c. CD cord-010119-t1x9gknd 11383 1 Results result NNS cord-010119-t1x9gknd 11383 2 / / SYM cord-010119-t1x9gknd 11383 3 Finding finding NN cord-010119-t1x9gknd 11383 4 : : : cord-010119-t1x9gknd 11384 1 The the DT cord-010119-t1x9gknd 11384 2 temperature temperature NN cord-010119-t1x9gknd 11384 3 recorded record VBN cord-010119-t1x9gknd 11384 4 from from IN cord-010119-t1x9gknd 11384 5 the the DT cord-010119-t1x9gknd 11384 6 thermometer thermometer NN cord-010119-t1x9gknd 11384 7 on on IN cord-010119-t1x9gknd 11384 8 top top NN cord-010119-t1x9gknd 11384 9 of of IN cord-010119-t1x9gknd 11384 10 the the DT cord-010119-t1x9gknd 11384 11 units unit NNS cord-010119-t1x9gknd 11384 12 in in IN cord-010119-t1x9gknd 11384 13 all all DT cord-010119-t1x9gknd 11384 14 five five CD cord-010119-t1x9gknd 11384 15 coolers cooler NNS cord-010119-t1x9gknd 11384 16 reached reach VBD cord-010119-t1x9gknd 11384 17 > > NNS cord-010119-t1x9gknd 11384 18 68C 68c NN cord-010119-t1x9gknd 11384 19 in in IN cord-010119-t1x9gknd 11384 20 75 75 CD cord-010119-t1x9gknd 11384 21 minutes minute NNS cord-010119-t1x9gknd 11384 22 as as IN cord-010119-t1x9gknd 11384 23 shown show VBN cord-010119-t1x9gknd 11384 24 in in IN cord-010119-t1x9gknd 11384 25 Table Table NNP cord-010119-t1x9gknd 11384 26 1 1 CD cord-010119-t1x9gknd 11384 27 . . . cord-010119-t1x9gknd 11385 1 The the DT cord-010119-t1x9gknd 11385 2 control control NN cord-010119-t1x9gknd 11385 3 thermometer thermometer NN cord-010119-t1x9gknd 11385 4 recorded record VBD cord-010119-t1x9gknd 11385 5 temperatures temperature NNS cord-010119-t1x9gknd 11385 6 maintained maintain VBD cord-010119-t1x9gknd 11385 7 at at IN cord-010119-t1x9gknd 11385 8 1 1 CD cord-010119-t1x9gknd 11385 9 - - HYPH cord-010119-t1x9gknd 11385 10 68C 68c NN cord-010119-t1x9gknd 11385 11 for for IN cord-010119-t1x9gknd 11385 12 the the DT cord-010119-t1x9gknd 11385 13 entire entire JJ cord-010119-t1x9gknd 11385 14 12 12 CD cord-010119-t1x9gknd 11385 15 hour hour NN cord-010119-t1x9gknd 11385 16 observation observation NN cord-010119-t1x9gknd 11385 17 period period NN cord-010119-t1x9gknd 11385 18 in in IN cord-010119-t1x9gknd 11385 19 both both CC cord-010119-t1x9gknd 11385 20 the the DT cord-010119-t1x9gknd 11385 21 large large JJ cord-010119-t1x9gknd 11385 22 and and CC cord-010119-t1x9gknd 11385 23 medium medium JJ cord-010119-t1x9gknd 11385 24 cooler cooler NN cord-010119-t1x9gknd 11385 25 . . . cord-010119-t1x9gknd 11386 1 Conclusion conclusion NN cord-010119-t1x9gknd 11386 2 : : : cord-010119-t1x9gknd 11386 3 When when WRB cord-010119-t1x9gknd 11386 4 units unit NNS cord-010119-t1x9gknd 11386 5 are be VBP cord-010119-t1x9gknd 11386 6 placed place VBN cord-010119-t1x9gknd 11386 7 on on IN cord-010119-t1x9gknd 11386 8 top top NN cord-010119-t1x9gknd 11386 9 of of IN cord-010119-t1x9gknd 11386 10 the the DT cord-010119-t1x9gknd 11386 11 ice ice NN cord-010119-t1x9gknd 11386 12 in in IN cord-010119-t1x9gknd 11386 13 a a DT cord-010119-t1x9gknd 11386 14 cooler cooler NN cord-010119-t1x9gknd 11386 15 , , , cord-010119-t1x9gknd 11386 16 the the DT cord-010119-t1x9gknd 11386 17 temperature temperature NN cord-010119-t1x9gknd 11386 18 is be VBZ cord-010119-t1x9gknd 11386 19 not not RB cord-010119-t1x9gknd 11386 20 reliably reliably RB cord-010119-t1x9gknd 11386 21 maintained maintain VBN cord-010119-t1x9gknd 11386 22 at at IN cord-010119-t1x9gknd 11386 23 1 1 CD cord-010119-t1x9gknd 11386 24 - - HYPH cord-010119-t1x9gknd 11386 25 68C 68C NNS cord-010119-t1x9gknd 11386 26 for for IN cord-010119-t1x9gknd 11386 27 more more JJR cord-010119-t1x9gknd 11386 28 than than IN cord-010119-t1x9gknd 11386 29 45 45 CD cord-010119-t1x9gknd 11386 30 minutes minute NNS cord-010119-t1x9gknd 11386 31 . . . cord-010119-t1x9gknd 11387 1 These these DT cord-010119-t1x9gknd 11387 2 data datum NNS cord-010119-t1x9gknd 11387 3 support support VBP cord-010119-t1x9gknd 11387 4 a a DT cord-010119-t1x9gknd 11387 5 policy policy NN cord-010119-t1x9gknd 11387 6 of of IN cord-010119-t1x9gknd 11387 7 wasting waste VBG cord-010119-t1x9gknd 11387 8 units unit NNS cord-010119-t1x9gknd 11387 9 that that WDT cord-010119-t1x9gknd 11387 10 are be VBP cord-010119-t1x9gknd 11387 11 returned return VBN cord-010119-t1x9gknd 11387 12 to to IN cord-010119-t1x9gknd 11387 13 the the DT cord-010119-t1x9gknd 11387 14 blood blood NN cord-010119-t1x9gknd 11387 15 bank bank NN cord-010119-t1x9gknd 11387 16 with with IN cord-010119-t1x9gknd 11387 17 RBC RBC NNP cord-010119-t1x9gknd 11387 18 units unit NNS cord-010119-t1x9gknd 11387 19 on on IN cord-010119-t1x9gknd 11387 20 top top NN cord-010119-t1x9gknd 11387 21 of of IN cord-010119-t1x9gknd 11387 22 the the DT cord-010119-t1x9gknd 11387 23 ice ice NN cord-010119-t1x9gknd 11387 24 . . . cord-010119-t1x9gknd 11388 1 Background Background NNP cord-010119-t1x9gknd 11388 2 / / SYM cord-010119-t1x9gknd 11388 3 Case Case NNP cord-010119-t1x9gknd 11388 4 Studies Studies NNPS cord-010119-t1x9gknd 11389 1 : : : cord-010119-t1x9gknd 11389 2 An an DT cord-010119-t1x9gknd 11389 3 FDA FDA NNP cord-010119-t1x9gknd 11389 4 draft draft NN cord-010119-t1x9gknd 11389 5 guidance guidance NN cord-010119-t1x9gknd 11389 6 has have VBZ cord-010119-t1x9gknd 11389 7 highlighted highlight VBN cord-010119-t1x9gknd 11389 8 the the DT cord-010119-t1x9gknd 11389 9 need need NN cord-010119-t1x9gknd 11389 10 to to TO cord-010119-t1x9gknd 11389 11 reduce reduce VB cord-010119-t1x9gknd 11389 12 the the DT cord-010119-t1x9gknd 11389 13 risk risk NN cord-010119-t1x9gknd 11389 14 of of IN cord-010119-t1x9gknd 11389 15 bacterial bacterial JJ cord-010119-t1x9gknd 11389 16 contamination contamination NN cord-010119-t1x9gknd 11389 17 of of IN cord-010119-t1x9gknd 11389 18 platelet platelet NN cord-010119-t1x9gknd 11389 19 components component NNS cord-010119-t1x9gknd 11389 20 ( ( -LRB- cord-010119-t1x9gknd 11389 21 PC pc NN cord-010119-t1x9gknd 11389 22 ) ) -RRB- cord-010119-t1x9gknd 11389 23 via via IN cord-010119-t1x9gknd 11389 24 pathogen pathogen NN cord-010119-t1x9gknd 11389 25 reduction reduction NN cord-010119-t1x9gknd 11389 26 ( ( -LRB- cord-010119-t1x9gknd 11389 27 PR PR NNP cord-010119-t1x9gknd 11389 28 ) ) -RRB- cord-010119-t1x9gknd 11389 29 or or CC cord-010119-t1x9gknd 11389 30 secondary secondary JJ cord-010119-t1x9gknd 11389 31 rapid rapid JJ cord-010119-t1x9gknd 11389 32 testing testing NN cord-010119-t1x9gknd 11389 33 ( ( -LRB- cord-010119-t1x9gknd 11389 34 RT RT NNP cord-010119-t1x9gknd 11389 35 ) ) -RRB- cord-010119-t1x9gknd 11389 36 . . . cord-010119-t1x9gknd 11390 1 Hospitals hospital NNS cord-010119-t1x9gknd 11390 2 must must MD cord-010119-t1x9gknd 11390 3 understand understand VB cord-010119-t1x9gknd 11390 4 the the DT cord-010119-t1x9gknd 11390 5 cost cost NN cord-010119-t1x9gknd 11390 6 implications implication NNS cord-010119-t1x9gknd 11390 7 that that WDT cord-010119-t1x9gknd 11390 8 may may MD cord-010119-t1x9gknd 11390 9 result result VB cord-010119-t1x9gknd 11390 10 . . . cord-010119-t1x9gknd 11391 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11391 2 objective objective NN cord-010119-t1x9gknd 11391 3 was be VBD cord-010119-t1x9gknd 11391 4 to to TO cord-010119-t1x9gknd 11391 5 create create VB cord-010119-t1x9gknd 11391 6 an an DT cord-010119-t1x9gknd 11391 7 interactive interactive JJ cord-010119-t1x9gknd 11391 8 model model NN cord-010119-t1x9gknd 11391 9 to to TO cord-010119-t1x9gknd 11391 10 analyze analyze VB cord-010119-t1x9gknd 11391 11 the the DT cord-010119-t1x9gknd 11391 12 budget budget NN cord-010119-t1x9gknd 11391 13 impact impact NN cord-010119-t1x9gknd 11391 14 for for IN cord-010119-t1x9gknd 11391 15 different different JJ cord-010119-t1x9gknd 11391 16 PC pc NN cord-010119-t1x9gknd 11391 17 types type NNS cord-010119-t1x9gknd 11391 18 across across IN cord-010119-t1x9gknd 11391 19 the the DT cord-010119-t1x9gknd 11391 20 range range NN cord-010119-t1x9gknd 11391 21 of of IN cord-010119-t1x9gknd 11391 22 existing exist VBG cord-010119-t1x9gknd 11391 23 US US NNP cord-010119-t1x9gknd 11391 24 hospitals hospital NNS cord-010119-t1x9gknd 11391 25 . . . cord-010119-t1x9gknd 11392 1 Study Study NNP cord-010119-t1x9gknd 11392 2 Design Design NNP cord-010119-t1x9gknd 11392 3 / / SYM cord-010119-t1x9gknd 11392 4 Methods method NNS cord-010119-t1x9gknd 11392 5 : : : cord-010119-t1x9gknd 11393 1 An an DT cord-010119-t1x9gknd 11393 2 Excel Excel NNP cord-010119-t1x9gknd 11393 3 model model NN cord-010119-t1x9gknd 11393 4 was be VBD cord-010119-t1x9gknd 11393 5 built build VBN cord-010119-t1x9gknd 11393 6 and and CC cord-010119-t1x9gknd 11393 7 populated populate VBN cord-010119-t1x9gknd 11393 8 with with IN cord-010119-t1x9gknd 11393 9 base base NN cord-010119-t1x9gknd 11393 10 case case NN cord-010119-t1x9gknd 11393 11 costs cost NNS cord-010119-t1x9gknd 11393 12 and and CC cord-010119-t1x9gknd 11393 13 probabilities probability NNS cord-010119-t1x9gknd 11393 14 identified identify VBN cord-010119-t1x9gknd 11393 15 through through IN cord-010119-t1x9gknd 11393 16 literature literature NN cord-010119-t1x9gknd 11393 17 search search NN cord-010119-t1x9gknd 11393 18 as as RB cord-010119-t1x9gknd 11393 19 well well RB cord-010119-t1x9gknd 11393 20 as as IN cord-010119-t1x9gknd 11393 21 through through IN cord-010119-t1x9gknd 11393 22 a a DT cord-010119-t1x9gknd 11393 23 survey survey NN cord-010119-t1x9gknd 11393 24 administered administer VBN cord-010119-t1x9gknd 11393 25 to to IN cord-010119-t1x9gknd 11393 26 27 27 CD cord-010119-t1x9gknd 11393 27 US US NNP cord-010119-t1x9gknd 11393 28 hospital hospital NN cord-010119-t1x9gknd 11393 29 transfusion transfusion NN cord-010119-t1x9gknd 11393 30 service service NN cord-010119-t1x9gknd 11393 31 directors director NNS cord-010119-t1x9gknd 11393 32 . . . cord-010119-t1x9gknd 11394 1 The the DT cord-010119-t1x9gknd 11394 2 model model NN cord-010119-t1x9gknd 11394 3 was be VBD cord-010119-t1x9gknd 11394 4 reviewed review VBN cord-010119-t1x9gknd 11394 5 and and CC cord-010119-t1x9gknd 11394 6 refined refine VBN cord-010119-t1x9gknd 11394 7 by by IN cord-010119-t1x9gknd 11394 8 a a DT cord-010119-t1x9gknd 11394 9 panel panel NN cord-010119-t1x9gknd 11394 10 of of IN cord-010119-t1x9gknd 11394 11 seven seven CD cord-010119-t1x9gknd 11394 12 transfusion transfusion NN cord-010119-t1x9gknd 11394 13 medicine medicine NN cord-010119-t1x9gknd 11394 14 physicians physician NNS cord-010119-t1x9gknd 11394 15 . . . cord-010119-t1x9gknd 11395 1 The the DT cord-010119-t1x9gknd 11395 2 model model NN cord-010119-t1x9gknd 11395 3 allows allow VBZ cord-010119-t1x9gknd 11395 4 base base NN cord-010119-t1x9gknd 11395 5 - - HYPH cord-010119-t1x9gknd 11395 6 case case NN cord-010119-t1x9gknd 11395 7 assumptions assumption NNS cord-010119-t1x9gknd 11395 8 to to TO cord-010119-t1x9gknd 11395 9 be be VB cord-010119-t1x9gknd 11395 10 overwritten overwrite VBN cord-010119-t1x9gknd 11395 11 with with IN cord-010119-t1x9gknd 11395 12 values value NNS cord-010119-t1x9gknd 11395 13 specific specific JJ cord-010119-t1x9gknd 11395 14 to to IN cord-010119-t1x9gknd 11395 15 the the DT cord-010119-t1x9gknd 11395 16 institution institution NN cord-010119-t1x9gknd 11395 17 . . . cord-010119-t1x9gknd 11396 1 Three three CD cord-010119-t1x9gknd 11396 2 scenarios scenario NNS cord-010119-t1x9gknd 11396 3 were be VBD cord-010119-t1x9gknd 11396 4 generated generate VBN cord-010119-t1x9gknd 11396 5 to to TO cord-010119-t1x9gknd 11396 6 compare compare VB cord-010119-t1x9gknd 11396 7 annual annual JJ cord-010119-t1x9gknd 11396 8 costs cost NNS cord-010119-t1x9gknd 11396 9 of of IN cord-010119-t1x9gknd 11396 10 plt plt NNP cord-010119-t1x9gknd 11396 11 acquisition acquisition NN cord-010119-t1x9gknd 11396 12 , , , cord-010119-t1x9gknd 11396 13 testing testing NN cord-010119-t1x9gknd 11396 14 , , , cord-010119-t1x9gknd 11396 15 wastage wastage NN cord-010119-t1x9gknd 11396 16 , , , cord-010119-t1x9gknd 11396 17 dispensing dispense VBG cord-010119-t1x9gknd 11396 18 /transfusion /transfusion NN cord-010119-t1x9gknd 11396 19 , , , cord-010119-t1x9gknd 11396 20 adverse adverse JJ cord-010119-t1x9gknd 11396 21 events event NNS cord-010119-t1x9gknd 11396 22 ( ( -LRB- cord-010119-t1x9gknd 11396 23 AE AE NNP cord-010119-t1x9gknd 11396 24 ) ) -RRB- cord-010119-t1x9gknd 11396 25 , , , cord-010119-t1x9gknd 11396 26 shelflife shelflife NNP cord-010119-t1x9gknd 11396 27 , , , cord-010119-t1x9gknd 11396 28 and and CC cord-010119-t1x9gknd 11396 29 reimbursement reimbursement NN cord-010119-t1x9gknd 11396 30 for for IN cord-010119-t1x9gknd 11396 31 a a DT cord-010119-t1x9gknd 11396 32 hospital hospital NN cord-010119-t1x9gknd 11396 33 that that WDT cord-010119-t1x9gknd 11396 34 purchases purchase VBZ cord-010119-t1x9gknd 11396 35 all all DT cord-010119-t1x9gknd 11396 36 of of IN cord-010119-t1x9gknd 11396 37 its -PRON- PRP$ cord-010119-t1x9gknd 11396 38 PCs pc NNS cord-010119-t1x9gknd 11396 39 : : : cord-010119-t1x9gknd 11396 40 100 100 CD cord-010119-t1x9gknd 11396 41 % % NN cord-010119-t1x9gknd 11396 42 conventional conventional JJ cord-010119-t1x9gknd 11396 43 ( ( -LRB- cord-010119-t1x9gknd 11396 44 C C NNP cord-010119-t1x9gknd 11396 45 - - HYPH cord-010119-t1x9gknd 11396 46 PC PC NNP cord-010119-t1x9gknd 11396 47 ) ) -RRB- cord-010119-t1x9gknd 11396 48 , , , cord-010119-t1x9gknd 11396 49 100 100 CD cord-010119-t1x9gknd 11396 50 % % NN cord-010119-t1x9gknd 11396 51 PR pr NN cord-010119-t1x9gknd 11396 52 - - HYPH cord-010119-t1x9gknd 11396 53 PC pc NN cord-010119-t1x9gknd 11396 54 , , , cord-010119-t1x9gknd 11396 55 and and CC cord-010119-t1x9gknd 11396 56 mix mix NN cord-010119-t1x9gknd 11396 57 of of IN cord-010119-t1x9gknd 11396 58 75 75 CD cord-010119-t1x9gknd 11396 59 % % NN cord-010119-t1x9gknd 11396 60 C c NN cord-010119-t1x9gknd 11396 61 - - HYPH cord-010119-t1x9gknd 11396 62 PC/25 PC/25 NNP cord-010119-t1x9gknd 11396 63 % % NN cord-010119-t1x9gknd 11396 64 PR pr NN cord-010119-t1x9gknd 11396 65 - - HYPH cord-010119-t1x9gknd 11396 66 PC pc NN cord-010119-t1x9gknd 11396 67 . . . cord-010119-t1x9gknd 11397 1 The the DT cord-010119-t1x9gknd 11397 2 model model NN cord-010119-t1x9gknd 11397 3 predicts predict VBZ cord-010119-t1x9gknd 11397 4 a a DT cord-010119-t1x9gknd 11397 5 modest modest JJ cord-010119-t1x9gknd 11397 6 ( ( -LRB- cord-010119-t1x9gknd 11397 7 $ $ $ cord-010119-t1x9gknd 11397 8 4 4 CD cord-010119-t1x9gknd 11397 9 % % NN cord-010119-t1x9gknd 11397 10 ) ) -RRB- cord-010119-t1x9gknd 11398 1 cost cost NN cord-010119-t1x9gknd 11398 2 increase increase NN cord-010119-t1x9gknd 11398 3 for for IN cord-010119-t1x9gknd 11398 4 PR pr NN cord-010119-t1x9gknd 11398 5 - - HYPH cord-010119-t1x9gknd 11398 6 PC pc NN cord-010119-t1x9gknd 11398 7 compared compare VBN cord-010119-t1x9gknd 11398 8 to to IN cord-010119-t1x9gknd 11399 1 C C NNP cord-010119-t1x9gknd 11399 2 - - HYPH cord-010119-t1x9gknd 11399 3 PC pc NN cord-010119-t1x9gknd 11399 4 depending depend VBG cord-010119-t1x9gknd 11399 5 on on IN cord-010119-t1x9gknd 11399 6 the the DT cord-010119-t1x9gknd 11399 7 degree degree NN cord-010119-t1x9gknd 11399 8 of of IN cord-010119-t1x9gknd 11399 9 PR PR NNP cord-010119-t1x9gknd 11399 10 conversion conversion NN cord-010119-t1x9gknd 11399 11 ; ; : cord-010119-t1x9gknd 11399 12 this this DT cord-010119-t1x9gknd 11399 13 takes take VBZ cord-010119-t1x9gknd 11399 14 into into IN cord-010119-t1x9gknd 11399 15 account account NN cord-010119-t1x9gknd 11399 16 cost cost NN cord-010119-t1x9gknd 11399 17 offsets offset NNS cord-010119-t1x9gknd 11399 18 such such JJ cord-010119-t1x9gknd 11399 19 as as IN cord-010119-t1x9gknd 11399 20 elimination elimination NN cord-010119-t1x9gknd 11399 21 of of IN cord-010119-t1x9gknd 11399 22 BD bd NN cord-010119-t1x9gknd 11399 23 and and CC cord-010119-t1x9gknd 11399 24 irradiation irradiation NN cord-010119-t1x9gknd 11399 25 , , , cord-010119-t1x9gknd 11399 26 decreased decrease VBD cord-010119-t1x9gknd 11399 27 waste waste NN cord-010119-t1x9gknd 11399 28 due due IN cord-010119-t1x9gknd 11399 29 to to IN cord-010119-t1x9gknd 11399 30 increased increase VBN cord-010119-t1x9gknd 11399 31 shelf shelf NN cord-010119-t1x9gknd 11399 32 - - HYPH cord-010119-t1x9gknd 11399 33 life life NN cord-010119-t1x9gknd 11399 34 , , , cord-010119-t1x9gknd 11399 35 and and CC cord-010119-t1x9gknd 11399 36 outpatient outpatient NN cord-010119-t1x9gknd 11399 37 reimbursement reimbursement NN cord-010119-t1x9gknd 11399 38 . . . cord-010119-t1x9gknd 11400 1 The the DT cord-010119-t1x9gknd 11400 2 effective effective JJ cord-010119-t1x9gknd 11400 3 PC pc NN cord-010119-t1x9gknd 11400 4 shelf shelf NN cord-010119-t1x9gknd 11400 5 - - HYPH cord-010119-t1x9gknd 11400 6 life life NN cord-010119-t1x9gknd 11400 7 is be VBZ cord-010119-t1x9gknd 11400 8 potentially potentially RB cord-010119-t1x9gknd 11400 9 increased increase VBN cord-010119-t1x9gknd 11400 10 with with IN cord-010119-t1x9gknd 11400 11 PR PR NNP cord-010119-t1x9gknd 11400 12 due due IN cord-010119-t1x9gknd 11400 13 to to IN cord-010119-t1x9gknd 11400 14 elimination elimination NN cord-010119-t1x9gknd 11400 15 of of IN cord-010119-t1x9gknd 11400 16 BD BD NNP cord-010119-t1x9gknd 11400 17 , , , cord-010119-t1x9gknd 11400 18 and and CC cord-010119-t1x9gknd 11400 19 is be VBZ cord-010119-t1x9gknd 11400 20 dependent dependent JJ cord-010119-t1x9gknd 11400 21 on on IN cord-010119-t1x9gknd 11400 22 NAT NAT NNP cord-010119-t1x9gknd 11400 23 turnaround turnaround NN cord-010119-t1x9gknd 11400 24 time time NN cord-010119-t1x9gknd 11400 25 . . . cord-010119-t1x9gknd 11401 1 Benefits benefit NNS cord-010119-t1x9gknd 11401 2 not not RB cord-010119-t1x9gknd 11401 3 captured capture VBN cord-010119-t1x9gknd 11401 4 by by IN cord-010119-t1x9gknd 11401 5 the the DT cord-010119-t1x9gknd 11401 6 model model NN cord-010119-t1x9gknd 11401 7 include include VBP cord-010119-t1x9gknd 11401 8 transfusion transfusion NN cord-010119-t1x9gknd 11401 9 - - HYPH cord-010119-t1x9gknd 11401 10 transmitted transmit VBN cord-010119-t1x9gknd 11401 11 infectious infectious JJ cord-010119-t1x9gknd 11401 12 risk risk NN cord-010119-t1x9gknd 11401 13 mitigation mitigation NN cord-010119-t1x9gknd 11401 14 from from IN cord-010119-t1x9gknd 11401 15 emerging emerge VBG cord-010119-t1x9gknd 11401 16 pathogens pathogen NNS cord-010119-t1x9gknd 11401 17 , , , cord-010119-t1x9gknd 11401 18 which which WDT cord-010119-t1x9gknd 11401 19 may may MD cord-010119-t1x9gknd 11401 20 impact impact VB cord-010119-t1x9gknd 11401 21 cost cost NN cord-010119-t1x9gknd 11401 22 / / SYM cord-010119-t1x9gknd 11401 23 benefit benefit NN cord-010119-t1x9gknd 11401 24 analyses analysis NNS cord-010119-t1x9gknd 11401 25 . . . cord-010119-t1x9gknd 11402 1 Future future JJ cord-010119-t1x9gknd 11402 2 iterations iteration NNS cord-010119-t1x9gknd 11402 3 of of IN cord-010119-t1x9gknd 11402 4 this this DT cord-010119-t1x9gknd 11402 5 model model NN cord-010119-t1x9gknd 11402 6 will will MD cord-010119-t1x9gknd 11402 7 also also RB cord-010119-t1x9gknd 11402 8 enable enable VB cord-010119-t1x9gknd 11402 9 hospitals hospital NNS cord-010119-t1x9gknd 11402 10 to to TO cord-010119-t1x9gknd 11402 11 consider consider VB cord-010119-t1x9gknd 11402 12 scenarios scenario NNS cord-010119-t1x9gknd 11402 13 in in IN cord-010119-t1x9gknd 11402 14 which which WDT cord-010119-t1x9gknd 11402 15 RT RT NNP cord-010119-t1x9gknd 11402 16 is be VBZ cord-010119-t1x9gknd 11402 17 used use VBN cord-010119-t1x9gknd 11402 18 . . . cord-010119-t1x9gknd 11403 1 This this DT cord-010119-t1x9gknd 11403 2 model model NN cord-010119-t1x9gknd 11403 3 can can MD cord-010119-t1x9gknd 11403 4 serve serve VB cord-010119-t1x9gknd 11403 5 as as IN cord-010119-t1x9gknd 11403 6 an an DT cord-010119-t1x9gknd 11403 7 important important JJ cord-010119-t1x9gknd 11403 8 tool tool NN cord-010119-t1x9gknd 11403 9 for for IN cord-010119-t1x9gknd 11403 10 hospitals hospital NNS cord-010119-t1x9gknd 11403 11 considering consider VBG cord-010119-t1x9gknd 11403 12 PR PR NNP cord-010119-t1x9gknd 11403 13 adoption adoption NN cord-010119-t1x9gknd 11403 14 . . . cord-010119-t1x9gknd 11404 1 in in IN cord-010119-t1x9gknd 11404 2 January January NNP cord-010119-t1x9gknd 11404 3 2011 2011 CD cord-010119-t1x9gknd 11404 4 . . . cord-010119-t1x9gknd 11405 1 A a DT cord-010119-t1x9gknd 11405 2 report report NN cord-010119-t1x9gknd 11405 3 was be VBD cord-010119-t1x9gknd 11405 4 created create VBN cord-010119-t1x9gknd 11405 5 to to TO cord-010119-t1x9gknd 11405 6 identify identify VB cord-010119-t1x9gknd 11405 7 donors donor NNS cord-010119-t1x9gknd 11405 8 previously previously RB cord-010119-t1x9gknd 11405 9 classified classify VBN cord-010119-t1x9gknd 11405 10 as as IN cord-010119-t1x9gknd 11405 11 rare rare JJ cord-010119-t1x9gknd 11405 12 according accord VBG cord-010119-t1x9gknd 11405 13 to to IN cord-010119-t1x9gknd 11405 14 the the DT cord-010119-t1x9gknd 11405 15 American American NNP cord-010119-t1x9gknd 11405 16 Rare Rare NNP cord-010119-t1x9gknd 11405 17 Donor Donor NNP cord-010119-t1x9gknd 11405 18 Program Program NNP cord-010119-t1x9gknd 11405 19 ( ( -LRB- cord-010119-t1x9gknd 11405 20 ARDP ARDP NNP cord-010119-t1x9gknd 11405 21 ) ) -RRB- cord-010119-t1x9gknd 11405 22 criteria criterion NNS cord-010119-t1x9gknd 11405 23 . . . cord-010119-t1x9gknd 11406 1 Donors donor NNS cord-010119-t1x9gknd 11406 2 are be VBP cord-010119-t1x9gknd 11406 3 classified classify VBN cord-010119-t1x9gknd 11406 4 as as IN cord-010119-t1x9gknd 11406 5 rare rare JJ cord-010119-t1x9gknd 11406 6 by by IN cord-010119-t1x9gknd 11406 7 meeting meet VBG cord-010119-t1x9gknd 11406 8 one one CD cord-010119-t1x9gknd 11406 9 of of IN cord-010119-t1x9gknd 11406 10 the the DT cord-010119-t1x9gknd 11406 11 following follow VBG cord-010119-t1x9gknd 11406 12 : : : cord-010119-t1x9gknd 11406 13 highprevalence highprevalence NNP cord-010119-t1x9gknd 11406 14 antigen antigen NNP cord-010119-t1x9gknd 11406 15 negative negative JJ cord-010119-t1x9gknd 11406 16 , , , cord-010119-t1x9gknd 11406 17 multiple multiple JJ cord-010119-t1x9gknd 11406 18 common common JJ cord-010119-t1x9gknd 11406 19 antigen antigen NN cord-010119-t1x9gknd 11406 20 negative negative JJ cord-010119-t1x9gknd 11406 21 , , , cord-010119-t1x9gknd 11406 22 or or CC cord-010119-t1x9gknd 11406 23 IgA IgA NNP cord-010119-t1x9gknd 11406 24 deficient deficient JJ cord-010119-t1x9gknd 11406 25 . . . cord-010119-t1x9gknd 11407 1 The the DT cord-010119-t1x9gknd 11407 2 new new JJ cord-010119-t1x9gknd 11407 3 process process NN cord-010119-t1x9gknd 11407 4 utilized utilize VBN cord-010119-t1x9gknd 11407 5 the the DT cord-010119-t1x9gknd 11407 6 report report NN cord-010119-t1x9gknd 11407 7 and and CC cord-010119-t1x9gknd 11407 8 involved involve VBD cord-010119-t1x9gknd 11407 9 sending send VBG cord-010119-t1x9gknd 11407 10 a a DT cord-010119-t1x9gknd 11407 11 letter letter NN cord-010119-t1x9gknd 11407 12 to to IN cord-010119-t1x9gknd 11407 13 the the DT cord-010119-t1x9gknd 11407 14 donors donor NNS cord-010119-t1x9gknd 11407 15 notifying notify VBG cord-010119-t1x9gknd 11407 16 them -PRON- PRP cord-010119-t1x9gknd 11407 17 of of IN cord-010119-t1x9gknd 11407 18 their -PRON- PRP$ cord-010119-t1x9gknd 11407 19 rare rare JJ cord-010119-t1x9gknd 11407 20 donor donor NN cord-010119-t1x9gknd 11407 21 status status NN cord-010119-t1x9gknd 11407 22 and and CC cord-010119-t1x9gknd 11407 23 encouraging encourage VBG cord-010119-t1x9gknd 11407 24 them -PRON- PRP cord-010119-t1x9gknd 11407 25 to to TO cord-010119-t1x9gknd 11407 26 continue continue VB cord-010119-t1x9gknd 11407 27 to to TO cord-010119-t1x9gknd 11407 28 donate donate VB cord-010119-t1x9gknd 11407 29 . . . cord-010119-t1x9gknd 11408 1 A a DT cord-010119-t1x9gknd 11408 2 database database NN cord-010119-t1x9gknd 11408 3 was be VBD cord-010119-t1x9gknd 11408 4 created create VBN cord-010119-t1x9gknd 11408 5 to to TO cord-010119-t1x9gknd 11408 6 track track VB cord-010119-t1x9gknd 11408 7 the the DT cord-010119-t1x9gknd 11408 8 letters letter NNS cord-010119-t1x9gknd 11408 9 sent send VBN cord-010119-t1x9gknd 11408 10 to to IN cord-010119-t1x9gknd 11408 11 rare rare JJ cord-010119-t1x9gknd 11408 12 donors donor NNS cord-010119-t1x9gknd 11408 13 . . . cord-010119-t1x9gknd 11409 1 In in IN cord-010119-t1x9gknd 11409 2 August August NNP cord-010119-t1x9gknd 11409 3 2013 2013 CD cord-010119-t1x9gknd 11409 4 , , , cord-010119-t1x9gknd 11409 5 inventory inventory NN cord-010119-t1x9gknd 11409 6 reduction reduction NN cord-010119-t1x9gknd 11409 7 efforts effort NNS cord-010119-t1x9gknd 11409 8 were be VBD cord-010119-t1x9gknd 11409 9 implemented implement VBN cord-010119-t1x9gknd 11409 10 to to TO cord-010119-t1x9gknd 11409 11 gradually gradually RB cord-010119-t1x9gknd 11409 12 decrease decrease VB cord-010119-t1x9gknd 11409 13 the the DT cord-010119-t1x9gknd 11409 14 number number NN cord-010119-t1x9gknd 11409 15 of of IN cord-010119-t1x9gknd 11409 16 allogeneic allogeneic JJ cord-010119-t1x9gknd 11409 17 red red JJ cord-010119-t1x9gknd 11409 18 blood blood NN cord-010119-t1x9gknd 11409 19 cells cell NNS cord-010119-t1x9gknd 11409 20 ( ( -LRB- cord-010119-t1x9gknd 11409 21 RBC RBC NNP cord-010119-t1x9gknd 11409 22 ) ) -RRB- cord-010119-t1x9gknd 11409 23 collected collect VBD cord-010119-t1x9gknd 11409 24 to to TO cord-010119-t1x9gknd 11409 25 minimize minimize VB cord-010119-t1x9gknd 11409 26 unit unit NN cord-010119-t1x9gknd 11409 27 age age NN cord-010119-t1x9gknd 11409 28 at at IN cord-010119-t1x9gknd 11409 29 transfusion transfusion NN cord-010119-t1x9gknd 11409 30 . . . cord-010119-t1x9gknd 11410 1 The the DT cord-010119-t1x9gknd 11410 2 inventory inventory NN cord-010119-t1x9gknd 11410 3 reduction reduction NN cord-010119-t1x9gknd 11410 4 occurred occur VBD cord-010119-t1x9gknd 11410 5 in in IN cord-010119-t1x9gknd 11410 6 phases phase NNS cord-010119-t1x9gknd 11410 7 and and CC cord-010119-t1x9gknd 11410 8 was be VBD cord-010119-t1x9gknd 11410 9 completed complete VBN cord-010119-t1x9gknd 11410 10 by by IN cord-010119-t1x9gknd 11410 11 January January NNP cord-010119-t1x9gknd 11410 12 2015 2015 CD cord-010119-t1x9gknd 11410 13 . . . cord-010119-t1x9gknd 11411 1 A a DT cord-010119-t1x9gknd 11411 2 study study NN cord-010119-t1x9gknd 11411 3 was be VBD cord-010119-t1x9gknd 11411 4 performed perform VBN cord-010119-t1x9gknd 11411 5 to to TO cord-010119-t1x9gknd 11411 6 determine determine VB cord-010119-t1x9gknd 11411 7 the the DT cord-010119-t1x9gknd 11411 8 impact impact NN cord-010119-t1x9gknd 11411 9 of of IN cord-010119-t1x9gknd 11411 10 the the DT cord-010119-t1x9gknd 11411 11 inventory inventory NN cord-010119-t1x9gknd 11411 12 reduction reduction NN cord-010119-t1x9gknd 11411 13 on on IN cord-010119-t1x9gknd 11411 14 the the DT cord-010119-t1x9gknd 11411 15 number number NN cord-010119-t1x9gknd 11411 16 of of IN cord-010119-t1x9gknd 11411 17 rare rare JJ cord-010119-t1x9gknd 11411 18 donor donor NN cord-010119-t1x9gknd 11411 19 donations donation NNS cord-010119-t1x9gknd 11411 20 . . . cord-010119-t1x9gknd 11412 1 Study Study NNP cord-010119-t1x9gknd 11412 2 Design Design NNP cord-010119-t1x9gknd 11412 3 / / SYM cord-010119-t1x9gknd 11412 4 Methods method NNS cord-010119-t1x9gknd 11412 5 : : : cord-010119-t1x9gknd 11413 1 The the DT cord-010119-t1x9gknd 11413 2 total total JJ cord-010119-t1x9gknd 11413 3 number number NN cord-010119-t1x9gknd 11413 4 of of IN cord-010119-t1x9gknd 11413 5 allogeneic allogeneic JJ cord-010119-t1x9gknd 11413 6 RBC RBC NNP cord-010119-t1x9gknd 11413 7 donations donation NNS cord-010119-t1x9gknd 11413 8 , , , cord-010119-t1x9gknd 11413 9 rare rare JJ cord-010119-t1x9gknd 11413 10 donor donor NN cord-010119-t1x9gknd 11413 11 donations donation NNS cord-010119-t1x9gknd 11413 12 , , , cord-010119-t1x9gknd 11413 13 and and CC cord-010119-t1x9gknd 11413 14 number number NN cord-010119-t1x9gknd 11413 15 of of IN cord-010119-t1x9gknd 11413 16 rare rare JJ cord-010119-t1x9gknd 11413 17 donor donor NN cord-010119-t1x9gknd 11413 18 letters letter NNS cord-010119-t1x9gknd 11413 19 sent send VBN cord-010119-t1x9gknd 11413 20 was be VBD cord-010119-t1x9gknd 11413 21 analyzed analyze VBN cord-010119-t1x9gknd 11413 22 from from IN cord-010119-t1x9gknd 11413 23 2010 2010 CD cord-010119-t1x9gknd 11413 24 to to IN cord-010119-t1x9gknd 11413 25 2016 2016 CD cord-010119-t1x9gknd 11413 26 ( ( -LRB- cord-010119-t1x9gknd 11413 27 see see VB cord-010119-t1x9gknd 11413 28 Table table NN cord-010119-t1x9gknd 11413 29 ) ) -RRB- cord-010119-t1x9gknd 11413 30 . . . cord-010119-t1x9gknd 11414 1 The the DT cord-010119-t1x9gknd 11414 2 percentage percentage NN cord-010119-t1x9gknd 11414 3 of of IN cord-010119-t1x9gknd 11414 4 rare rare JJ cord-010119-t1x9gknd 11414 5 donor donor NN cord-010119-t1x9gknd 11414 6 donations donation NNS cord-010119-t1x9gknd 11414 7 per per IN cord-010119-t1x9gknd 11414 8 year year NN cord-010119-t1x9gknd 11414 9 was be VBD cord-010119-t1x9gknd 11414 10 calculated calculate VBN cord-010119-t1x9gknd 11414 11 . . . cord-010119-t1x9gknd 11415 1 Background Background NNP cord-010119-t1x9gknd 11415 2 / / SYM cord-010119-t1x9gknd 11415 3 Case Case NNP cord-010119-t1x9gknd 11415 4 Studies Studies NNPS cord-010119-t1x9gknd 11415 5 : : : cord-010119-t1x9gknd 11415 6 Blood blood NN cord-010119-t1x9gknd 11415 7 Centers Centers NNPS cord-010119-t1x9gknd 11415 8 ( ( -LRB- cord-010119-t1x9gknd 11415 9 Clients client NNS cord-010119-t1x9gknd 11415 10 ) ) -RRB- cord-010119-t1x9gknd 11415 11 often often RB cord-010119-t1x9gknd 11415 12 carry carry VBP cord-010119-t1x9gknd 11415 13 low low JJ cord-010119-t1x9gknd 11415 14 inventory inventory NN cord-010119-t1x9gknd 11415 15 of of IN cord-010119-t1x9gknd 11415 16 blood blood NN cord-010119-t1x9gknd 11415 17 and and CC cord-010119-t1x9gknd 11415 18 blood blood NN cord-010119-t1x9gknd 11415 19 components component NNS cord-010119-t1x9gknd 11415 20 . . . cord-010119-t1x9gknd 11416 1 Laboratories laboratory NNS cord-010119-t1x9gknd 11416 2 performing perform VBG cord-010119-t1x9gknd 11416 3 donor donor NN cord-010119-t1x9gknd 11416 4 screening screening NN cord-010119-t1x9gknd 11416 5 therefore therefore RB cord-010119-t1x9gknd 11416 6 , , , cord-010119-t1x9gknd 11416 7 have have VBP cord-010119-t1x9gknd 11416 8 limited limit VBN cord-010119-t1x9gknd 11416 9 time time NN cord-010119-t1x9gknd 11416 10 to to TO cord-010119-t1x9gknd 11416 11 determine determine VB cord-010119-t1x9gknd 11416 12 the the DT cord-010119-t1x9gknd 11416 13 presence presence NN cord-010119-t1x9gknd 11416 14 or or CC cord-010119-t1x9gknd 11416 15 absence absence NN cord-010119-t1x9gknd 11416 16 of of IN cord-010119-t1x9gknd 11416 17 infectious infectious JJ cord-010119-t1x9gknd 11416 18 disease disease NN cord-010119-t1x9gknd 11416 19 within within IN cord-010119-t1x9gknd 11416 20 these these DT cord-010119-t1x9gknd 11416 21 products product NNS cord-010119-t1x9gknd 11416 22 . . . cord-010119-t1x9gknd 11417 1 In in IN cord-010119-t1x9gknd 11417 2 order order NN cord-010119-t1x9gknd 11417 3 to to TO cord-010119-t1x9gknd 11417 4 measure measure VB cord-010119-t1x9gknd 11417 5 and and CC cord-010119-t1x9gknd 11417 6 ensure ensure VB cord-010119-t1x9gknd 11417 7 expedited expedited JJ cord-010119-t1x9gknd 11417 8 donor donor NN cord-010119-t1x9gknd 11417 9 screening screening NN cord-010119-t1x9gknd 11417 10 we -PRON- PRP cord-010119-t1x9gknd 11417 11 implemented implement VBD cord-010119-t1x9gknd 11417 12 a a DT cord-010119-t1x9gknd 11417 13 daily daily JJ cord-010119-t1x9gknd 11417 14 performance performance NN cord-010119-t1x9gknd 11417 15 metric metric NN cord-010119-t1x9gknd 11417 16 consisting consisting NN cord-010119-t1x9gknd 11417 17 of of IN cord-010119-t1x9gknd 11417 18 upload upload JJ cord-010119-t1x9gknd 11417 19 time time NN cord-010119-t1x9gknd 11417 20 goals goal NNS cord-010119-t1x9gknd 11417 21 for for IN cord-010119-t1x9gknd 11417 22 release release NN cord-010119-t1x9gknd 11417 23 of of IN cord-010119-t1x9gknd 11417 24 results result NNS cord-010119-t1x9gknd 11417 25 to to IN cord-010119-t1x9gknd 11417 26 Clients client NNS cord-010119-t1x9gknd 11417 27 . . . cord-010119-t1x9gknd 11418 1 In in IN cord-010119-t1x9gknd 11418 2 2016 2016 CD cord-010119-t1x9gknd 11418 3 , , , cord-010119-t1x9gknd 11418 4 ZKV ZKV NNP cord-010119-t1x9gknd 11418 5 - - HYPH cord-010119-t1x9gknd 11418 6 NAT NAT NNP cord-010119-t1x9gknd 11418 7 testing testing NN cord-010119-t1x9gknd 11418 8 was be VBD cord-010119-t1x9gknd 11418 9 implement implement VBN cord-010119-t1x9gknd 11418 10 for for IN cord-010119-t1x9gknd 11418 11 travel travel NN cord-010119-t1x9gknd 11418 12 deferral deferral NN cord-010119-t1x9gknd 11418 13 donors donor NNS cord-010119-t1x9gknd 11418 14 ( ( -LRB- cord-010119-t1x9gknd 11418 15 July July NNP cord-010119-t1x9gknd 11418 16 ) ) -RRB- cord-010119-t1x9gknd 11418 17 , , , cord-010119-t1x9gknd 11418 18 followed follow VBN cord-010119-t1x9gknd 11418 19 by by IN cord-010119-t1x9gknd 11418 20 universal universal JJ cord-010119-t1x9gknd 11418 21 individual individual JJ cord-010119-t1x9gknd 11418 22 donor donor NN cord-010119-t1x9gknd 11418 23 screening screening NN cord-010119-t1x9gknd 11418 24 in in IN cord-010119-t1x9gknd 11418 25 September September NNP cord-010119-t1x9gknd 11418 26 and and CC cord-010119-t1x9gknd 11418 27 November November NNP cord-010119-t1x9gknd 11418 28 in in IN cord-010119-t1x9gknd 11418 29 response response NN cord-010119-t1x9gknd 11418 30 to to IN cord-010119-t1x9gknd 11418 31 the the DT cord-010119-t1x9gknd 11418 32 FDA FDA NNP cord-010119-t1x9gknd 11418 33 recommendations recommendation NNS cord-010119-t1x9gknd 11418 34 for for IN cord-010119-t1x9gknd 11418 35 " " `` cord-010119-t1x9gknd 11418 36 Reducing reduce VBG cord-010119-t1x9gknd 11418 37 the the DT cord-010119-t1x9gknd 11418 38 Risk Risk NNP cord-010119-t1x9gknd 11418 39 of of IN cord-010119-t1x9gknd 11418 40 ZKV ZKV NNP cord-010119-t1x9gknd 11418 41 Transmission Transmission NNP cord-010119-t1x9gknd 11418 42 by by IN cord-010119-t1x9gknd 11418 43 Blood blood NN cord-010119-t1x9gknd 11418 44 and and CC cord-010119-t1x9gknd 11418 45 Blood blood NN cord-010119-t1x9gknd 11418 46 Components Components NNP cord-010119-t1x9gknd 11418 47 " " '' cord-010119-t1x9gknd 11418 48 . . . cord-010119-t1x9gknd 11419 1 Per per IN cord-010119-t1x9gknd 11419 2 the the DT cord-010119-t1x9gknd 11419 3 FDA FDA NNP cord-010119-t1x9gknd 11419 4 guidance guidance NN cord-010119-t1x9gknd 11419 5 we -PRON- PRP cord-010119-t1x9gknd 11419 6 implemented implement VBD cord-010119-t1x9gknd 11419 7 mandatory mandatory JJ cord-010119-t1x9gknd 11419 8 ZKV ZKV NNP cord-010119-t1x9gknd 11419 9 testing testing NN cord-010119-t1x9gknd 11419 10 for for IN cord-010119-t1x9gknd 11419 11 Clients client NNS cord-010119-t1x9gknd 11419 12 with with IN cord-010119-t1x9gknd 11419 13 proximity proximity NN cord-010119-t1x9gknd 11419 14 to to IN cord-010119-t1x9gknd 11419 15 areas area NNS cord-010119-t1x9gknd 11419 16 with with IN cord-010119-t1x9gknd 11419 17 locally locally RB cord-010119-t1x9gknd 11419 18 acquired acquire VBN cord-010119-t1x9gknd 11419 19 mosquito mosquito NN cord-010119-t1x9gknd 11419 20 - - HYPH cord-010119-t1x9gknd 11419 21 borne bear VBN cord-010119-t1x9gknd 11419 22 cases case NNS cord-010119-t1x9gknd 11419 23 of of IN cord-010119-t1x9gknd 11419 24 ZKV ZKV NNP cord-010119-t1x9gknd 11419 25 within within IN cord-010119-t1x9gknd 11419 26 4 4 CD cord-010119-t1x9gknd 11419 27 weeks week NNS cord-010119-t1x9gknd 11419 28 ( ( -LRB- cord-010119-t1x9gknd 11419 29 Sept. September NNP cord-010119-t1x9gknd 11419 30 Phase Phase NNP cord-010119-t1x9gknd 11419 31 1 1 CD cord-010119-t1x9gknd 11419 32 ) ) -RRB- cord-010119-t1x9gknd 11419 33 and and CC cord-010119-t1x9gknd 11419 34 nationwide nationwide RB cord-010119-t1x9gknd 11419 35 within within IN cord-010119-t1x9gknd 11419 36 12 12 CD cord-010119-t1x9gknd 11419 37 weeks week NNS cord-010119-t1x9gknd 11419 38 ( ( -LRB- cord-010119-t1x9gknd 11419 39 Nov. November NNP cord-010119-t1x9gknd 11419 40 Phase Phase NNP cord-010119-t1x9gknd 11419 41 2 2 CD cord-010119-t1x9gknd 11419 42 ) ) -RRB- cord-010119-t1x9gknd 11419 43 . . . cord-010119-t1x9gknd 11420 1 ZKV zkv NN cord-010119-t1x9gknd 11420 2 testing testing NN cord-010119-t1x9gknd 11420 3 is be VBZ cord-010119-t1x9gknd 11420 4 performed perform VBN cord-010119-t1x9gknd 11420 5 on on IN cord-010119-t1x9gknd 11420 6 individual individual JJ cord-010119-t1x9gknd 11420 7 samples sample NNS cord-010119-t1x9gknd 11420 8 , , , cord-010119-t1x9gknd 11420 9 unlike unlike IN cord-010119-t1x9gknd 11420 10 all all DT cord-010119-t1x9gknd 11420 11 other other JJ cord-010119-t1x9gknd 11420 12 NAT NAT NNP cord-010119-t1x9gknd 11420 13 tests test NNS cord-010119-t1x9gknd 11420 14 that that WDT cord-010119-t1x9gknd 11420 15 are be VBP cord-010119-t1x9gknd 11420 16 performed perform VBN cord-010119-t1x9gknd 11420 17 in in IN cord-010119-t1x9gknd 11420 18 minipools minipools NNP cord-010119-t1x9gknd 11420 19 ( ( -LRB- cord-010119-t1x9gknd 11420 20 16-donations 16-donations CD cord-010119-t1x9gknd 11420 21 ) ) -RRB- cord-010119-t1x9gknd 11420 22 . . . cord-010119-t1x9gknd 11421 1 Therefore therefore RB cord-010119-t1x9gknd 11421 2 ZKV ZKV NNP cord-010119-t1x9gknd 11421 3 testing testing NN cord-010119-t1x9gknd 11421 4 has have VBZ cord-010119-t1x9gknd 11421 5 a a DT cord-010119-t1x9gknd 11421 6 disproportionate disproportionate JJ cord-010119-t1x9gknd 11421 7 impact impact NN cord-010119-t1x9gknd 11421 8 on on IN cord-010119-t1x9gknd 11421 9 the the DT cord-010119-t1x9gknd 11421 10 turnaround turnaround NN cord-010119-t1x9gknd 11421 11 times time NNS cord-010119-t1x9gknd 11421 12 for for IN cord-010119-t1x9gknd 11421 13 testing testing NN cord-010119-t1x9gknd 11421 14 , , , cord-010119-t1x9gknd 11421 15 which which WDT cord-010119-t1x9gknd 11421 16 we -PRON- PRP cord-010119-t1x9gknd 11421 17 analyzed analyze VBD cord-010119-t1x9gknd 11421 18 in in IN cord-010119-t1x9gknd 11421 19 this this DT cord-010119-t1x9gknd 11421 20 study study NN cord-010119-t1x9gknd 11421 21 . . . cord-010119-t1x9gknd 11422 1 Study Study NNP cord-010119-t1x9gknd 11422 2 Design Design NNP cord-010119-t1x9gknd 11422 3 / / SYM cord-010119-t1x9gknd 11422 4 Method method NN cord-010119-t1x9gknd 11422 5 : : : cord-010119-t1x9gknd 11423 1 Within within IN cord-010119-t1x9gknd 11423 2 two two CD cord-010119-t1x9gknd 11423 3 regional regional JJ cord-010119-t1x9gknd 11423 4 testing testing NN cord-010119-t1x9gknd 11423 5 labs lab NNS cord-010119-t1x9gknd 11423 6 , , , cord-010119-t1x9gknd 11423 7 participating participate VBG cord-010119-t1x9gknd 11423 8 in in IN cord-010119-t1x9gknd 11423 9 the the DT cord-010119-t1x9gknd 11423 10 same same JJ cord-010119-t1x9gknd 11423 11 clinical clinical JJ cord-010119-t1x9gknd 11423 12 trial trial NN cord-010119-t1x9gknd 11423 13 , , , cord-010119-t1x9gknd 11423 14 Lab Lab NNP cord-010119-t1x9gknd 11423 15 1 1 CD cord-010119-t1x9gknd 11423 16 had have VBD cord-010119-t1x9gknd 11423 17 86 86 CD cord-010119-t1x9gknd 11423 18 % % NN cord-010119-t1x9gknd 11423 19 and and CC cord-010119-t1x9gknd 11423 20 Lab Lab NNP cord-010119-t1x9gknd 11423 21 2 2 CD cord-010119-t1x9gknd 11423 22 had have VBD cord-010119-t1x9gknd 11423 23 77 77 CD cord-010119-t1x9gknd 11423 24 % % NN cord-010119-t1x9gknd 11423 25 of of IN cord-010119-t1x9gknd 11423 26 Clients client NNS cord-010119-t1x9gknd 11423 27 requiring require VBG cord-010119-t1x9gknd 11423 28 universal universal JJ cord-010119-t1x9gknd 11423 29 ZKV ZKV NNP cord-010119-t1x9gknd 11423 30 testing testing NN cord-010119-t1x9gknd 11423 31 . . . cord-010119-t1x9gknd 11424 1 We -PRON- PRP cord-010119-t1x9gknd 11424 2 evaluated evaluate VBD cord-010119-t1x9gknd 11424 3 a a DT cord-010119-t1x9gknd 11424 4 12-month 12-month JJ cord-010119-t1x9gknd 11424 5 test test NN cord-010119-t1x9gknd 11424 6 result result NN cord-010119-t1x9gknd 11424 7 upload upload NN cord-010119-t1x9gknd 11424 8 performance performance NN cord-010119-t1x9gknd 11424 9 period period NN cord-010119-t1x9gknd 11424 10 to to TO cord-010119-t1x9gknd 11424 11 determine determine VB cord-010119-t1x9gknd 11424 12 the the DT cord-010119-t1x9gknd 11424 13 impact impact NN cord-010119-t1x9gknd 11424 14 of of IN cord-010119-t1x9gknd 11424 15 ZKV ZKV NNP cord-010119-t1x9gknd 11424 16 test test NN cord-010119-t1x9gknd 11424 17 implementation implementation NN cord-010119-t1x9gknd 11424 18 . . . cord-010119-t1x9gknd 11425 1 Results result NNS cord-010119-t1x9gknd 11426 1 /Finding /finde VBG cord-010119-t1x9gknd 11426 2 : : : cord-010119-t1x9gknd 11427 1 During during IN cord-010119-t1x9gknd 11427 2 2016 2016 CD cord-010119-t1x9gknd 11427 3 , , , cord-010119-t1x9gknd 11427 4 Lab lab NN cord-010119-t1x9gknd 11427 5 1 1 CD cord-010119-t1x9gknd 11427 6 upload upload NN cord-010119-t1x9gknd 11427 7 time time NN cord-010119-t1x9gknd 11427 8 performance performance NN cord-010119-t1x9gknd 11427 9 ranged range VBD cord-010119-t1x9gknd 11427 10 from from IN cord-010119-t1x9gknd 11427 11 92 92 CD cord-010119-t1x9gknd 11427 12 % % NN cord-010119-t1x9gknd 11427 13 to to IN cord-010119-t1x9gknd 11427 14 94.2 94.2 CD cord-010119-t1x9gknd 11427 15 % % NN cord-010119-t1x9gknd 11427 16 from from IN cord-010119-t1x9gknd 11427 17 January January NNP cord-010119-t1x9gknd 11427 18 to to IN cord-010119-t1x9gknd 11427 19 July July NNP cord-010119-t1x9gknd 11427 20 ; ; : cord-010119-t1x9gknd 11427 21 upload upload VB cord-010119-t1x9gknd 11427 22 time time NN cord-010119-t1x9gknd 11427 23 performance performance NN cord-010119-t1x9gknd 11427 24 fell fall VBD cord-010119-t1x9gknd 11427 25 between between IN cord-010119-t1x9gknd 11427 26 August August NNP cord-010119-t1x9gknd 11427 27 through through IN cord-010119-t1x9gknd 11427 28 November November NNP cord-010119-t1x9gknd 11427 29 , , , cord-010119-t1x9gknd 11427 30 returning return VBG cord-010119-t1x9gknd 11427 31 to to IN cord-010119-t1x9gknd 11427 32 94.2 94.2 CD cord-010119-t1x9gknd 11427 33 % % NN cord-010119-t1x9gknd 11427 34 performance performance NN cord-010119-t1x9gknd 11427 35 in in IN cord-010119-t1x9gknd 11427 36 December December NNP cord-010119-t1x9gknd 11427 37 . . . cord-010119-t1x9gknd 11428 1 Lab lab NN cord-010119-t1x9gknd 11428 2 2 2 CD cord-010119-t1x9gknd 11428 3 upload upload NN cord-010119-t1x9gknd 11428 4 time time NN cord-010119-t1x9gknd 11428 5 performance performance NN cord-010119-t1x9gknd 11428 6 ranged range VBD cord-010119-t1x9gknd 11428 7 from from IN cord-010119-t1x9gknd 11428 8 91.4 91.4 CD cord-010119-t1x9gknd 11428 9 % % NN cord-010119-t1x9gknd 11428 10 to to IN cord-010119-t1x9gknd 11428 11 95.3 95.3 CD cord-010119-t1x9gknd 11428 12 % % NN cord-010119-t1x9gknd 11428 13 January January NNP cord-010119-t1x9gknd 11428 14 to to IN cord-010119-t1x9gknd 11428 15 August August NNP cord-010119-t1x9gknd 11428 16 . . . cord-010119-t1x9gknd 11429 1 Performance performance NN cord-010119-t1x9gknd 11429 2 fell fall VBD cord-010119-t1x9gknd 11429 3 September September NNP cord-010119-t1x9gknd 11429 4 through through IN cord-010119-t1x9gknd 11429 5 December December NNP cord-010119-t1x9gknd 11429 6 83.3 83.3 CD cord-010119-t1x9gknd 11429 7 % % NN cord-010119-t1x9gknd 11429 8 -88.5 -88.5 CD cord-010119-t1x9gknd 11429 9 % % NN cord-010119-t1x9gknd 11429 10 . . . cord-010119-t1x9gknd 11430 1 Lab lab NN cord-010119-t1x9gknd 11430 2 1 1 CD cord-010119-t1x9gknd 11430 3 experienced experience VBD cord-010119-t1x9gknd 11430 4 a a DT cord-010119-t1x9gknd 11430 5 low low NN cord-010119-t1x9gknd 11430 6 of of IN cord-010119-t1x9gknd 11430 7 75 75 CD cord-010119-t1x9gknd 11430 8 % % NN cord-010119-t1x9gknd 11430 9 upload upload NN cord-010119-t1x9gknd 11430 10 time time NN cord-010119-t1x9gknd 11430 11 performance performance NN cord-010119-t1x9gknd 11430 12 during during IN cord-010119-t1x9gknd 11430 13 Phase phase NN cord-010119-t1x9gknd 11430 14 1 1 CD cord-010119-t1x9gknd 11430 15 when when WRB cord-010119-t1x9gknd 11430 16 there there EX cord-010119-t1x9gknd 11430 17 was be VBD cord-010119-t1x9gknd 11430 18 a a DT cord-010119-t1x9gknd 11430 19 rapid rapid JJ cord-010119-t1x9gknd 11430 20 implementation implementation NN cord-010119-t1x9gknd 11430 21 ; ; : cord-010119-t1x9gknd 11430 22 69 69 CD cord-010119-t1x9gknd 11430 23 % % NN cord-010119-t1x9gknd 11430 24 Clients client NNS cord-010119-t1x9gknd 11430 25 required require VBD cord-010119-t1x9gknd 11430 26 ZKV ZKV NNP cord-010119-t1x9gknd 11430 27 NAT NAT NNP cord-010119-t1x9gknd 11430 28 . . . cord-010119-t1x9gknd 11431 1 Improved improved JJ cord-010119-t1x9gknd 11431 2 performance performance NN cord-010119-t1x9gknd 11431 3 was be VBD cord-010119-t1x9gknd 11431 4 observed observe VBN cord-010119-t1x9gknd 11431 5 during during IN cord-010119-t1x9gknd 11431 6 Phase Phase NNP cord-010119-t1x9gknd 11431 7 2 2 CD cord-010119-t1x9gknd 11431 8 , , , cord-010119-t1x9gknd 11431 9 with with IN cord-010119-t1x9gknd 11431 10 a a DT cord-010119-t1x9gknd 11431 11 16 16 CD cord-010119-t1x9gknd 11431 12 % % NN cord-010119-t1x9gknd 11431 13 increase increase NN cord-010119-t1x9gknd 11431 14 in in IN cord-010119-t1x9gknd 11431 15 ZKV ZKV NNP cord-010119-t1x9gknd 11431 16 Clients client NNS cord-010119-t1x9gknd 11431 17 . . . cord-010119-t1x9gknd 11432 1 For for IN cord-010119-t1x9gknd 11432 2 Lab lab NN cord-010119-t1x9gknd 11432 3 2 2 CD cord-010119-t1x9gknd 11432 4 : : : cord-010119-t1x9gknd 11432 5 Phase phase NN cord-010119-t1x9gknd 11432 6 1 1 CD cord-010119-t1x9gknd 11432 7 experienced experience VBD cord-010119-t1x9gknd 11432 8 a a DT cord-010119-t1x9gknd 11432 9 modest modest JJ cord-010119-t1x9gknd 11432 10 decline decline NN cord-010119-t1x9gknd 11432 11 of of IN cord-010119-t1x9gknd 11432 12 upload upload NN cord-010119-t1x9gknd 11432 13 performance performance NN cord-010119-t1x9gknd 11432 14 ranging range VBG cord-010119-t1x9gknd 11432 15 from from IN cord-010119-t1x9gknd 11432 16 83.3 83.3 CD cord-010119-t1x9gknd 11432 17 % % NN cord-010119-t1x9gknd 11432 18 to to IN cord-010119-t1x9gknd 11432 19 88.5 88.5 CD cord-010119-t1x9gknd 11432 20 % % NN cord-010119-t1x9gknd 11432 21 with with IN cord-010119-t1x9gknd 11432 22 33.3 33.3 CD cord-010119-t1x9gknd 11432 23 % % NN cord-010119-t1x9gknd 11432 24 of of IN cord-010119-t1x9gknd 11432 25 Clients client NNS cord-010119-t1x9gknd 11432 26 implementing implement VBG cord-010119-t1x9gknd 11432 27 ZKV ZKV NNP cord-010119-t1x9gknd 11432 28 NAT NAT NNP cord-010119-t1x9gknd 11432 29 . . . cord-010119-t1x9gknd 11433 1 Performance performance NN cord-010119-t1x9gknd 11433 2 was be VBD cord-010119-t1x9gknd 11433 3 87.1 87.1 CD cord-010119-t1x9gknd 11433 4 % % NN cord-010119-t1x9gknd 11433 5 in in IN cord-010119-t1x9gknd 11433 6 Phase phase NN cord-010119-t1x9gknd 11433 7 2 2 CD cord-010119-t1x9gknd 11433 8 , , , cord-010119-t1x9gknd 11433 9 when when WRB cord-010119-t1x9gknd 11433 10 an an DT cord-010119-t1x9gknd 11433 11 additional additional JJ cord-010119-t1x9gknd 11433 12 43.3 43.3 CD cord-010119-t1x9gknd 11433 13 % % NN cord-010119-t1x9gknd 11433 14 of of IN cord-010119-t1x9gknd 11433 15 Clients client NNS cord-010119-t1x9gknd 11433 16 implemented implement VBD cord-010119-t1x9gknd 11433 17 ZKV ZKV NNP cord-010119-t1x9gknd 11433 18 testing testing NN cord-010119-t1x9gknd 11433 19 . . . cord-010119-t1x9gknd 11434 1 Conclusion conclusion NN cord-010119-t1x9gknd 11434 2 : : : cord-010119-t1x9gknd 11434 3 With with IN cord-010119-t1x9gknd 11434 4 an an DT cord-010119-t1x9gknd 11434 5 unprecedented unprecedented JJ cord-010119-t1x9gknd 11434 6 rapid rapid JJ cord-010119-t1x9gknd 11434 7 implementation implementation NN cord-010119-t1x9gknd 11434 8 of of IN cord-010119-t1x9gknd 11434 9 ZKV ZKV NNP cord-010119-t1x9gknd 11434 10 testing test VBG cord-010119-t1x9gknd 11434 11 our -PRON- PRP$ cord-010119-t1x9gknd 11434 12 laboratories laboratory NNS cord-010119-t1x9gknd 11434 13 experienced experience VBD cord-010119-t1x9gknd 11434 14 a a DT cord-010119-t1x9gknd 11434 15 short short JJ cord-010119-t1x9gknd 11434 16 period period NN cord-010119-t1x9gknd 11434 17 of of IN cord-010119-t1x9gknd 11434 18 reduced reduce VBN cord-010119-t1x9gknd 11434 19 ability ability NN cord-010119-t1x9gknd 11434 20 to to TO cord-010119-t1x9gknd 11434 21 maintain maintain VB cord-010119-t1x9gknd 11434 22 our -PRON- PRP$ cord-010119-t1x9gknd 11434 23 upload upload NN cord-010119-t1x9gknd 11434 24 time time NN cord-010119-t1x9gknd 11434 25 performance performance NN cord-010119-t1x9gknd 11434 26 metric metric NN cord-010119-t1x9gknd 11434 27 . . . cord-010119-t1x9gknd 11435 1 Enhanced enhanced JJ cord-010119-t1x9gknd 11435 2 Platelet platelet NN cord-010119-t1x9gknd 11435 3 Bacterial bacterial JJ cord-010119-t1x9gknd 11435 4 Screening screening NN cord-010119-t1x9gknd 11435 5 in in IN cord-010119-t1x9gknd 11435 6 an an DT cord-010119-t1x9gknd 11435 7 Eight eight CD cord-010119-t1x9gknd 11435 8 - - HYPH cord-010119-t1x9gknd 11435 9 Hospital Hospital NNP cord-010119-t1x9gknd 11435 10 System System NNP cord-010119-t1x9gknd 11435 11 Robin Robin NNP cord-010119-t1x9gknd 11435 12 Larson Larson NNP cord-010119-t1x9gknd 11436 1 * * NFP cord-010119-t1x9gknd 11436 2 1 1 CD cord-010119-t1x9gknd 11436 3 and and CC cord-010119-t1x9gknd 11436 4 Colleen Colleen NNP cord-010119-t1x9gknd 11436 5 A. A. NNP cord-010119-t1x9gknd 11436 6 Aronson Aronson NNP cord-010119-t1x9gknd 11436 7 2 2 CD cord-010119-t1x9gknd 11436 8 . . . cord-010119-t1x9gknd 11436 9 1 1 CD cord-010119-t1x9gknd 11436 10 Advocate Advocate NNP cord-010119-t1x9gknd 11436 11 Lutheran Lutheran NNP cord-010119-t1x9gknd 11436 12 General General NNP cord-010119-t1x9gknd 11436 13 Hospital Hospital NNP cord-010119-t1x9gknd 11436 14 , , , cord-010119-t1x9gknd 11436 15 2 2 CD cord-010119-t1x9gknd 11436 16 ACL ACL NNP cord-010119-t1x9gknd 11436 17 Laboratories/ Laboratories/ NNP cord-010119-t1x9gknd 11436 18 Advocate Advocate NNP cord-010119-t1x9gknd 11436 19 Hospitals Hospitals NNPS cord-010119-t1x9gknd 11436 20 Background Background NNP cord-010119-t1x9gknd 11436 21 / / SYM cord-010119-t1x9gknd 11436 22 Case Case NNP cord-010119-t1x9gknd 11436 23 Studies Studies NNPS cord-010119-t1x9gknd 11436 24 : : : cord-010119-t1x9gknd 11437 1 In in IN cord-010119-t1x9gknd 11437 2 response response NN cord-010119-t1x9gknd 11437 3 to to IN cord-010119-t1x9gknd 11437 4 two two CD cord-010119-t1x9gknd 11437 5 platelet platelet NN cord-010119-t1x9gknd 11437 6 - - HYPH cord-010119-t1x9gknd 11437 7 related relate VBN cord-010119-t1x9gknd 11437 8 septic septic JJ cord-010119-t1x9gknd 11437 9 transfusion transfusion NN cord-010119-t1x9gknd 11437 10 reactions reaction NNS cord-010119-t1x9gknd 11437 11 and and CC cord-010119-t1x9gknd 11437 12 the the DT cord-010119-t1x9gknd 11437 13 draft draft NN cord-010119-t1x9gknd 11437 14 FDA FDA NNP cord-010119-t1x9gknd 11437 15 guidance guidance NN cord-010119-t1x9gknd 11437 16 released release VBN cord-010119-t1x9gknd 11437 17 in in IN cord-010119-t1x9gknd 11437 18 March March NNP cord-010119-t1x9gknd 11437 19 2016 2016 CD cord-010119-t1x9gknd 11437 20 regarding regard VBG cord-010119-t1x9gknd 11437 21 bacterial bacterial JJ cord-010119-t1x9gknd 11437 22 risk risk NN cord-010119-t1x9gknd 11437 23 control control NN cord-010119-t1x9gknd 11437 24 strategies strategy NNS cord-010119-t1x9gknd 11437 25 for for IN cord-010119-t1x9gknd 11437 26 transfusion transfusion NN cord-010119-t1x9gknd 11437 27 services service NNS cord-010119-t1x9gknd 11437 28 , , , cord-010119-t1x9gknd 11437 29 an an DT cord-010119-t1x9gknd 11437 30 eight eight CD cord-010119-t1x9gknd 11437 31 - - HYPH cord-010119-t1x9gknd 11437 32 hospital hospital NN cord-010119-t1x9gknd 11437 33 system system NN cord-010119-t1x9gknd 11437 34 implemented implement VBD cord-010119-t1x9gknd 11437 35 the the DT cord-010119-t1x9gknd 11437 36 Verax Verax NNP cord-010119-t1x9gknd 11437 37 PGD PGD NNP cord-010119-t1x9gknd 11437 38 enhanced enhance VBN cord-010119-t1x9gknd 11437 39 platelet platelet NN cord-010119-t1x9gknd 11437 40 bacterial bacterial JJ cord-010119-t1x9gknd 11437 41 screening screening NN cord-010119-t1x9gknd 11437 42 test test NN cord-010119-t1x9gknd 11437 43 in in IN cord-010119-t1x9gknd 11437 44 6 6 CD cord-010119-t1x9gknd 11437 45 of of IN cord-010119-t1x9gknd 11437 46 the the DT cord-010119-t1x9gknd 11437 47 8 8 CD cord-010119-t1x9gknd 11437 48 hospital hospital NN cord-010119-t1x9gknd 11437 49 transfusion transfusion NN cord-010119-t1x9gknd 11437 50 services service NNS cord-010119-t1x9gknd 11437 51 . . . cord-010119-t1x9gknd 11438 1 The the DT cord-010119-t1x9gknd 11438 2 2 2 CD cord-010119-t1x9gknd 11438 3 sites site NNS cord-010119-t1x9gknd 11438 4 that that WDT cord-010119-t1x9gknd 11438 5 did do VBD cord-010119-t1x9gknd 11438 6 not not RB cord-010119-t1x9gknd 11438 7 implement implement VB cord-010119-t1x9gknd 11438 8 the the DT cord-010119-t1x9gknd 11438 9 test test NN cord-010119-t1x9gknd 11438 10 arranged arrange VBN cord-010119-t1x9gknd 11438 11 for for IN cord-010119-t1x9gknd 11438 12 fresh fresh JJ cord-010119-t1x9gknd 11438 13 platelets platelet NNS cord-010119-t1x9gknd 11438 14 to to TO cord-010119-t1x9gknd 11438 15 be be VB cord-010119-t1x9gknd 11438 16 rotated rotate VBN cord-010119-t1x9gknd 11438 17 in in RP cord-010119-t1x9gknd 11438 18 from from IN cord-010119-t1x9gknd 11438 19 the the DT cord-010119-t1x9gknd 11438 20 blood blood NN cord-010119-t1x9gknd 11438 21 supplier supplier NN cord-010119-t1x9gknd 11438 22 . . . cord-010119-t1x9gknd 11439 1 The the DT cord-010119-t1x9gknd 11439 2 6 6 CD cord-010119-t1x9gknd 11439 3 sites site NNS cord-010119-t1x9gknd 11439 4 which which WDT cord-010119-t1x9gknd 11439 5 implemented implement VBD cord-010119-t1x9gknd 11439 6 the the DT cord-010119-t1x9gknd 11439 7 Verax Verax NNP cord-010119-t1x9gknd 11439 8 PGD PGD NNP cord-010119-t1x9gknd 11439 9 test test NN cord-010119-t1x9gknd 11439 10 perform perform VBP cord-010119-t1x9gknd 11439 11 testing testing NN cord-010119-t1x9gknd 11439 12 on on IN cord-010119-t1x9gknd 11439 13 all all DT cord-010119-t1x9gknd 11439 14 day day NN cord-010119-t1x9gknd 11439 15 4 4 CD cord-010119-t1x9gknd 11439 16 and and CC cord-010119-t1x9gknd 11439 17 day day NN cord-010119-t1x9gknd 11439 18 5 5 CD cord-010119-t1x9gknd 11439 19 platelets platelet NNS cord-010119-t1x9gknd 11439 20 to to TO cord-010119-t1x9gknd 11439 21 be be VB cord-010119-t1x9gknd 11439 22 issued issue VBN cord-010119-t1x9gknd 11439 23 for for IN cord-010119-t1x9gknd 11439 24 transfusion transfusion NN cord-010119-t1x9gknd 11439 25 . . . cord-010119-t1x9gknd 11440 1 This this DT cord-010119-t1x9gknd 11440 2 abstract abstract NN cord-010119-t1x9gknd 11440 3 summarizes summarize VBZ cord-010119-t1x9gknd 11440 4 the the DT cord-010119-t1x9gknd 11440 5 data datum NNS cord-010119-t1x9gknd 11440 6 collected collect VBN cord-010119-t1x9gknd 11440 7 for for IN cord-010119-t1x9gknd 11440 8 the the DT cord-010119-t1x9gknd 11440 9 first first JJ cord-010119-t1x9gknd 11440 10 5 5 CD cord-010119-t1x9gknd 11440 11 weeks week NNS cord-010119-t1x9gknd 11440 12 of of IN cord-010119-t1x9gknd 11440 13 testing testing NN cord-010119-t1x9gknd 11440 14 . . . cord-010119-t1x9gknd 11441 1 Study Study NNP cord-010119-t1x9gknd 11441 2 Design Design NNP cord-010119-t1x9gknd 11441 3 / / SYM cord-010119-t1x9gknd 11441 4 Methods method NNS cord-010119-t1x9gknd 11441 5 : : : cord-010119-t1x9gknd 11442 1 Platelet platelet NN cord-010119-t1x9gknd 11442 2 bacterial bacterial JJ cord-010119-t1x9gknd 11442 3 testing testing NN cord-010119-t1x9gknd 11442 4 logs log NNS cord-010119-t1x9gknd 11442 5 were be VBD cord-010119-t1x9gknd 11442 6 reviewed review VBN cord-010119-t1x9gknd 11442 7 over over IN cord-010119-t1x9gknd 11442 8 the the DT cord-010119-t1x9gknd 11442 9 entire entire JJ cord-010119-t1x9gknd 11442 10 time time NN cord-010119-t1x9gknd 11442 11 period period NN cord-010119-t1x9gknd 11442 12 studied study VBD cord-010119-t1x9gknd 11442 13 for for IN cord-010119-t1x9gknd 11442 14 platelets platelet NNS cord-010119-t1x9gknd 11442 15 tested test VBN cord-010119-t1x9gknd 11442 16 on on IN cord-010119-t1x9gknd 11442 17 day day NN cord-010119-t1x9gknd 11442 18 4 4 CD cord-010119-t1x9gknd 11442 19 , , , cord-010119-t1x9gknd 11442 20 day day NN cord-010119-t1x9gknd 11442 21 5 5 CD cord-010119-t1x9gknd 11442 22 , , , cord-010119-t1x9gknd 11442 23 and and CC cord-010119-t1x9gknd 11442 24 those those DT cord-010119-t1x9gknd 11442 25 that that WDT cord-010119-t1x9gknd 11442 26 were be VBD cord-010119-t1x9gknd 11442 27 tested test VBN cord-010119-t1x9gknd 11442 28 twice twice RB cord-010119-t1x9gknd 11442 29 . . . cord-010119-t1x9gknd 11443 1 Inventory inventory NN cord-010119-t1x9gknd 11443 2 reports report NNS cord-010119-t1x9gknd 11443 3 were be VBD cord-010119-t1x9gknd 11443 4 reviewed review VBN cord-010119-t1x9gknd 11443 5 for for IN cord-010119-t1x9gknd 11443 6 platelets platelet NNS cord-010119-t1x9gknd 11443 7 issued issue VBN cord-010119-t1x9gknd 11443 8 on on IN cord-010119-t1x9gknd 11443 9 day day NN cord-010119-t1x9gknd 11443 10 2 2 CD cord-010119-t1x9gknd 11443 11 or or CC cord-010119-t1x9gknd 11443 12 day day NN cord-010119-t1x9gknd 11443 13 3 3 CD cord-010119-t1x9gknd 11443 14 that that WDT cord-010119-t1x9gknd 11443 15 did do VBD cord-010119-t1x9gknd 11443 16 not not RB cord-010119-t1x9gknd 11443 17 require require VB cord-010119-t1x9gknd 11443 18 testing testing NN cord-010119-t1x9gknd 11443 19 , , , cord-010119-t1x9gknd 11443 20 and and CC cord-010119-t1x9gknd 11443 21 for for IN cord-010119-t1x9gknd 11443 22 the the DT cord-010119-t1x9gknd 11443 23 total total JJ cord-010119-t1x9gknd 11443 24 number number NN cord-010119-t1x9gknd 11443 25 of of IN cord-010119-t1x9gknd 11443 26 platelets platelet NNS cord-010119-t1x9gknd 11443 27 issued issue VBN cord-010119-t1x9gknd 11443 28 over over IN cord-010119-t1x9gknd 11443 29 the the DT cord-010119-t1x9gknd 11443 30 time time NN cord-010119-t1x9gknd 11443 31 period period NN cord-010119-t1x9gknd 11443 32 studied study VBD cord-010119-t1x9gknd 11443 33 . . . cord-010119-t1x9gknd 11444 1 Results result NNS cord-010119-t1x9gknd 11444 2 / / SYM cord-010119-t1x9gknd 11444 3 Findings finding NNS cord-010119-t1x9gknd 11444 4 : : : cord-010119-t1x9gknd 11445 1 In in IN cord-010119-t1x9gknd 11445 2 the the DT cord-010119-t1x9gknd 11445 3 month month NN cord-010119-t1x9gknd 11445 4 of of IN cord-010119-t1x9gknd 11445 5 February February NNP cord-010119-t1x9gknd 11445 6 ( ( -LRB- cord-010119-t1x9gknd 11445 7 1 1 CD cord-010119-t1x9gknd 11445 8 week week NN cord-010119-t1x9gknd 11445 9 of of IN cord-010119-t1x9gknd 11445 10 performing perform VBG cord-010119-t1x9gknd 11445 11 the the DT cord-010119-t1x9gknd 11445 12 test test NN cord-010119-t1x9gknd 11445 13 ) ) -RRB- cord-010119-t1x9gknd 11445 14 , , , cord-010119-t1x9gknd 11445 15 48.1 48.1 CD cord-010119-t1x9gknd 11445 16 % % NN cord-010119-t1x9gknd 11445 17 of of IN cord-010119-t1x9gknd 11445 18 all all DT cord-010119-t1x9gknd 11445 19 platelets platelet NNS cord-010119-t1x9gknd 11445 20 issued issue VBN cord-010119-t1x9gknd 11445 21 by by IN cord-010119-t1x9gknd 11445 22 the the DT cord-010119-t1x9gknd 11445 23 6 6 CD cord-010119-t1x9gknd 11445 24 participating participate VBG cord-010119-t1x9gknd 11445 25 transfusion transfusion NN cord-010119-t1x9gknd 11445 26 services service NNS cord-010119-t1x9gknd 11445 27 were be VBD cord-010119-t1x9gknd 11445 28 day day NN cord-010119-t1x9gknd 11445 29 2 2 CD cord-010119-t1x9gknd 11445 30 or or CC cord-010119-t1x9gknd 11445 31 day day NN cord-010119-t1x9gknd 11445 32 3 3 CD cord-010119-t1x9gknd 11445 33 platelets platelet NNS cord-010119-t1x9gknd 11445 34 . . . cord-010119-t1x9gknd 11446 1 In in IN cord-010119-t1x9gknd 11446 2 March March NNP cord-010119-t1x9gknd 11446 3 that that DT cord-010119-t1x9gknd 11446 4 number number NN cord-010119-t1x9gknd 11446 5 dropped drop VBD cord-010119-t1x9gknd 11446 6 to to IN cord-010119-t1x9gknd 11446 7 29.9 29.9 CD cord-010119-t1x9gknd 11446 8 % % NN cord-010119-t1x9gknd 11446 9 . . . cord-010119-t1x9gknd 11447 1 It -PRON- PRP cord-010119-t1x9gknd 11447 2 is be VBZ cord-010119-t1x9gknd 11447 3 expected expect VBN cord-010119-t1x9gknd 11447 4 that that IN cord-010119-t1x9gknd 11447 5 this this DT cord-010119-t1x9gknd 11447 6 number number NN cord-010119-t1x9gknd 11447 7 will will MD cord-010119-t1x9gknd 11447 8 level level VB cord-010119-t1x9gknd 11447 9 off off RP cord-010119-t1x9gknd 11447 10 at at IN cord-010119-t1x9gknd 11447 11 some some DT cord-010119-t1x9gknd 11447 12 percentage percentage NN cord-010119-t1x9gknd 11447 13 at at IN cord-010119-t1x9gknd 11447 14 or or CC cord-010119-t1x9gknd 11447 15 below below IN cord-010119-t1x9gknd 11447 16 29.0 29.0 CD cord-010119-t1x9gknd 11447 17 % % NN cord-010119-t1x9gknd 11447 18 with with IN cord-010119-t1x9gknd 11447 19 further further JJ cord-010119-t1x9gknd 11447 20 data datum NNS cord-010119-t1x9gknd 11447 21 collection collection NN cord-010119-t1x9gknd 11447 22 . . . cord-010119-t1x9gknd 11448 1 In in IN cord-010119-t1x9gknd 11448 2 February February NNP cord-010119-t1x9gknd 11448 3 25.9 25.9 CD cord-010119-t1x9gknd 11448 4 % % NN cord-010119-t1x9gknd 11448 5 of of IN cord-010119-t1x9gknd 11448 6 platelets platelet NNS cord-010119-t1x9gknd 11448 7 were be VBD cord-010119-t1x9gknd 11448 8 tested test VBN cord-010119-t1x9gknd 11448 9 twice twice RB cord-010119-t1x9gknd 11448 10 prior prior RB cord-010119-t1x9gknd 11448 11 to to IN cord-010119-t1x9gknd 11448 12 final final JJ cord-010119-t1x9gknd 11448 13 issue issue NN cord-010119-t1x9gknd 11448 14 from from IN cord-010119-t1x9gknd 11448 15 the the DT cord-010119-t1x9gknd 11448 16 transfusion transfusion NN cord-010119-t1x9gknd 11448 17 services service NNS cord-010119-t1x9gknd 11448 18 . . . cord-010119-t1x9gknd 11449 1 In in IN cord-010119-t1x9gknd 11449 2 March March NNP cord-010119-t1x9gknd 11449 3 Conclusion Conclusion NNP cord-010119-t1x9gknd 11449 4 : : : cord-010119-t1x9gknd 11449 5 The the DT cord-010119-t1x9gknd 11449 6 percent percent NN cord-010119-t1x9gknd 11449 7 of of IN cord-010119-t1x9gknd 11449 8 platelets platelet NNS cord-010119-t1x9gknd 11449 9 issued issue VBN cord-010119-t1x9gknd 11449 10 fresh fresh JJ cord-010119-t1x9gknd 11449 11 ( ( -LRB- cord-010119-t1x9gknd 11449 12 day day NN cord-010119-t1x9gknd 11449 13 2 2 CD cord-010119-t1x9gknd 11449 14 or or CC cord-010119-t1x9gknd 11449 15 day day NN cord-010119-t1x9gknd 11449 16 3 3 CD cord-010119-t1x9gknd 11449 17 ) ) -RRB- cord-010119-t1x9gknd 11449 18 will will MD cord-010119-t1x9gknd 11449 19 likely likely RB cord-010119-t1x9gknd 11449 20 level level VB cord-010119-t1x9gknd 11449 21 off off RP cord-010119-t1x9gknd 11449 22 at at IN cord-010119-t1x9gknd 11449 23 some some DT cord-010119-t1x9gknd 11449 24 number number NN cord-010119-t1x9gknd 11449 25 at at IN cord-010119-t1x9gknd 11449 26 or or CC cord-010119-t1x9gknd 11449 27 below below IN cord-010119-t1x9gknd 11449 28 29.9 29.9 CD cord-010119-t1x9gknd 11449 29 % % NN cord-010119-t1x9gknd 11449 30 due due IN cord-010119-t1x9gknd 11449 31 to to IN cord-010119-t1x9gknd 11449 32 inventory inventory NN cord-010119-t1x9gknd 11449 33 management management NN cord-010119-t1x9gknd 11449 34 from from IN cord-010119-t1x9gknd 11449 35 both both CC cord-010119-t1x9gknd 11449 36 the the DT cord-010119-t1x9gknd 11449 37 blood blood NN cord-010119-t1x9gknd 11449 38 supplier supplier NN cord-010119-t1x9gknd 11449 39 and and CC cord-010119-t1x9gknd 11449 40 the the DT cord-010119-t1x9gknd 11449 41 individual individual JJ cord-010119-t1x9gknd 11449 42 transfusion transfusion NN cord-010119-t1x9gknd 11449 43 services service NNS cord-010119-t1x9gknd 11449 44 . . . cord-010119-t1x9gknd 11450 1 Testing testing NN cord-010119-t1x9gknd 11450 2 platelets platelet NNS cord-010119-t1x9gknd 11450 3 twice twice RB cord-010119-t1x9gknd 11450 4 is be VBZ cord-010119-t1x9gknd 11450 5 undesirable undesirable JJ cord-010119-t1x9gknd 11450 6 . . . cord-010119-t1x9gknd 11451 1 Ideally ideally RB cord-010119-t1x9gknd 11451 2 , , , cord-010119-t1x9gknd 11451 3 no no DT cord-010119-t1x9gknd 11451 4 platelets platelet NNS cord-010119-t1x9gknd 11451 5 would would MD cord-010119-t1x9gknd 11451 6 be be VB cord-010119-t1x9gknd 11451 7 tested test VBN cord-010119-t1x9gknd 11451 8 twice twice RB cord-010119-t1x9gknd 11451 9 as as IN cord-010119-t1x9gknd 11451 10 this this DT cord-010119-t1x9gknd 11451 11 represents represent VBZ cord-010119-t1x9gknd 11451 12 a a DT cord-010119-t1x9gknd 11451 13 high high JJ cord-010119-t1x9gknd 11451 14 cost cost NN cord-010119-t1x9gknd 11451 15 for for IN cord-010119-t1x9gknd 11451 16 both both CC cord-010119-t1x9gknd 11451 17 the the DT cord-010119-t1x9gknd 11451 18 test test NN cord-010119-t1x9gknd 11451 19 reagents reagent NNS cord-010119-t1x9gknd 11451 20 as as RB cord-010119-t1x9gknd 11451 21 well well RB cord-010119-t1x9gknd 11451 22 as as IN cord-010119-t1x9gknd 11451 23 the the DT cord-010119-t1x9gknd 11451 24 staff staff NN cord-010119-t1x9gknd 11451 25 time time NN cord-010119-t1x9gknd 11451 26 to to TO cord-010119-t1x9gknd 11451 27 complete complete VB cord-010119-t1x9gknd 11451 28 the the DT cord-010119-t1x9gknd 11451 29 testing testing NN cord-010119-t1x9gknd 11451 30 . . . cord-010119-t1x9gknd 11452 1 In in IN cord-010119-t1x9gknd 11452 2 addition addition NN cord-010119-t1x9gknd 11452 3 , , , cord-010119-t1x9gknd 11452 4 5 5 CD cord-010119-t1x9gknd 11452 5 of of IN cord-010119-t1x9gknd 11452 6 the the DT cord-010119-t1x9gknd 11452 7 6 6 CD cord-010119-t1x9gknd 11452 8 sites site NNS cord-010119-t1x9gknd 11452 9 performing perform VBG cord-010119-t1x9gknd 11452 10 testing testing NN cord-010119-t1x9gknd 11452 11 are be VBP cord-010119-t1x9gknd 11452 12 Level level NN cord-010119-t1x9gknd 11452 13 1 1 CD cord-010119-t1x9gknd 11452 14 Trauma Trauma NNP cord-010119-t1x9gknd 11452 15 Centers Centers NNPS cord-010119-t1x9gknd 11452 16 and and CC cord-010119-t1x9gknd 11452 17 need need VBP cord-010119-t1x9gknd 11452 18 to to TO cord-010119-t1x9gknd 11452 19 have have VB cord-010119-t1x9gknd 11452 20 tested test VBN cord-010119-t1x9gknd 11452 21 platelets platelet NNS cord-010119-t1x9gknd 11452 22 available available JJ cord-010119-t1x9gknd 11452 23 at at IN cord-010119-t1x9gknd 11452 24 all all DT cord-010119-t1x9gknd 11452 25 times time NNS cord-010119-t1x9gknd 11452 26 . . . cord-010119-t1x9gknd 11453 1 This this DT cord-010119-t1x9gknd 11453 2 will will MD cord-010119-t1x9gknd 11453 3 require require VB cord-010119-t1x9gknd 11453 4 some some DT cord-010119-t1x9gknd 11453 5 amount amount NN cord-010119-t1x9gknd 11453 6 of of IN cord-010119-t1x9gknd 11453 7 double double JJ cord-010119-t1x9gknd 11453 8 testing testing NN cord-010119-t1x9gknd 11453 9 , , , cord-010119-t1x9gknd 11453 10 but but CC cord-010119-t1x9gknd 11453 11 the the DT cord-010119-t1x9gknd 11453 12 goal goal NN cord-010119-t1x9gknd 11453 13 is be VBZ cord-010119-t1x9gknd 11453 14 to to TO cord-010119-t1x9gknd 11453 15 have have VB cord-010119-t1x9gknd 11453 16 this this DT cord-010119-t1x9gknd 11453 17 number number NN cord-010119-t1x9gknd 11453 18 be be VB cord-010119-t1x9gknd 11453 19 as as RB cord-010119-t1x9gknd 11453 20 low low JJ cord-010119-t1x9gknd 11453 21 as as IN cord-010119-t1x9gknd 11453 22 possible possible JJ cord-010119-t1x9gknd 11453 23 , , , cord-010119-t1x9gknd 11453 24 so so IN cord-010119-t1x9gknd 11453 25 that that IN cord-010119-t1x9gknd 11453 26 the the DT cord-010119-t1x9gknd 11453 27 percent percent NN cord-010119-t1x9gknd 11453 28 of of IN cord-010119-t1x9gknd 11453 29 tested test VBN cord-010119-t1x9gknd 11453 30 vs vs IN cord-010119-t1x9gknd 11453 31 issued issue VBN cord-010119-t1x9gknd 11453 32 platelets platelet NNS cord-010119-t1x9gknd 11453 33 does do VBZ cord-010119-t1x9gknd 11453 34 not not RB cord-010119-t1x9gknd 11453 35 exceed exceed VB cord-010119-t1x9gknd 11453 36 100 100 CD cord-010119-t1x9gknd 11453 37 % % NN cord-010119-t1x9gknd 11453 38 . . . cord-010119-t1x9gknd 11454 1 As as IN cord-010119-t1x9gknd 11454 2 the the DT cord-010119-t1x9gknd 11454 3 transfusion transfusion NN cord-010119-t1x9gknd 11454 4 service service NN cord-010119-t1x9gknd 11454 5 staff staff NN cord-010119-t1x9gknd 11454 6 becomes become VBZ cord-010119-t1x9gknd 11454 7 more more RBR cord-010119-t1x9gknd 11454 8 comfortable comfortable JJ cord-010119-t1x9gknd 11454 9 with with IN cord-010119-t1x9gknd 11454 10 judging judge VBG cord-010119-t1x9gknd 11454 11 inventory inventory NN cord-010119-t1x9gknd 11454 12 levels level NNS cord-010119-t1x9gknd 11454 13 and and CC cord-010119-t1x9gknd 11454 14 performing perform VBG cord-010119-t1x9gknd 11454 15 testing testing NN cord-010119-t1x9gknd 11454 16 , , , cord-010119-t1x9gknd 11454 17 it -PRON- PRP cord-010119-t1x9gknd 11454 18 is be VBZ cord-010119-t1x9gknd 11454 19 expected expect VBN cord-010119-t1x9gknd 11454 20 that that IN cord-010119-t1x9gknd 11454 21 the the DT cord-010119-t1x9gknd 11454 22 amount amount NN cord-010119-t1x9gknd 11454 23 of of IN cord-010119-t1x9gknd 11454 24 double double JJ cord-010119-t1x9gknd 11454 25 testing testing NN cord-010119-t1x9gknd 11454 26 will will MD cord-010119-t1x9gknd 11454 27 decrease decrease VB cord-010119-t1x9gknd 11454 28 . . . cord-010119-t1x9gknd 11455 1 Background Background NNP cord-010119-t1x9gknd 11455 2 / / SYM cord-010119-t1x9gknd 11455 3 Case Case NNP cord-010119-t1x9gknd 11455 4 Studies Studies NNPS cord-010119-t1x9gknd 11456 1 : : : cord-010119-t1x9gknd 11456 2 In in IN cord-010119-t1x9gknd 11456 3 order order NN cord-010119-t1x9gknd 11456 4 to to TO cord-010119-t1x9gknd 11456 5 make make VB cord-010119-t1x9gknd 11456 6 up up RP cord-010119-t1x9gknd 11456 7 for for IN cord-010119-t1x9gknd 11456 8 the the DT cord-010119-t1x9gknd 11456 9 deficiency deficiency NN cord-010119-t1x9gknd 11456 10 of of IN cord-010119-t1x9gknd 11456 11 the the DT cord-010119-t1x9gknd 11456 12 apheresis apheresis NN cord-010119-t1x9gknd 11456 13 platelets platelet NNS cord-010119-t1x9gknd 11456 14 in in IN cord-010119-t1x9gknd 11456 15 clinical clinical JJ cord-010119-t1x9gknd 11456 16 application application NN cord-010119-t1x9gknd 11456 17 , , , cord-010119-t1x9gknd 11456 18 and and CC cord-010119-t1x9gknd 11456 19 also also RB cord-010119-t1x9gknd 11456 20 to to TO cord-010119-t1x9gknd 11456 21 improve improve VB cord-010119-t1x9gknd 11456 22 the the DT cord-010119-t1x9gknd 11456 23 comprehensive comprehensive JJ cord-010119-t1x9gknd 11456 24 utilization utilization NN cord-010119-t1x9gknd 11456 25 of of IN cord-010119-t1x9gknd 11456 26 blood blood NN cord-010119-t1x9gknd 11456 27 , , , cord-010119-t1x9gknd 11456 28 we -PRON- PRP cord-010119-t1x9gknd 11456 29 investigate investigate VBP cord-010119-t1x9gknd 11456 30 the the DT cord-010119-t1x9gknd 11456 31 feasibility feasibility NN cord-010119-t1x9gknd 11456 32 of of IN cord-010119-t1x9gknd 11456 33 preparation preparation NN cord-010119-t1x9gknd 11456 34 of of IN cord-010119-t1x9gknd 11456 35 pooled pool VBN cord-010119-t1x9gknd 11456 36 platelet platelet NN cord-010119-t1x9gknd 11456 37 concentrates(PCs concentrates(pc NNS cord-010119-t1x9gknd 11456 38 ) ) -RRB- cord-010119-t1x9gknd 11456 39 for for IN cord-010119-t1x9gknd 11456 40 providing provide VBG cord-010119-t1x9gknd 11456 41 a a DT cord-010119-t1x9gknd 11456 42 reliable reliable JJ cord-010119-t1x9gknd 11456 43 source source NN cord-010119-t1x9gknd 11456 44 for for IN cord-010119-t1x9gknd 11456 45 clinical clinical JJ cord-010119-t1x9gknd 11456 46 application application NN cord-010119-t1x9gknd 11456 47 . . . cord-010119-t1x9gknd 11457 1 To to TO cord-010119-t1x9gknd 11457 2 speed speed VB cord-010119-t1x9gknd 11457 3 up up RP cord-010119-t1x9gknd 11457 4 the the DT cord-010119-t1x9gknd 11457 5 storage storage NN cord-010119-t1x9gknd 11457 6 research research NN cord-010119-t1x9gknd 11457 7 of of IN cord-010119-t1x9gknd 11457 8 pooled pool VBN cord-010119-t1x9gknd 11457 9 PCs pc NNS cord-010119-t1x9gknd 11457 10 in in IN cord-010119-t1x9gknd 11457 11 China China NNP cord-010119-t1x9gknd 11457 12 , , , cord-010119-t1x9gknd 11457 13 we -PRON- PRP cord-010119-t1x9gknd 11457 14 evaluate evaluate VBP cord-010119-t1x9gknd 11457 15 the the DT cord-010119-t1x9gknd 11457 16 changes change NNS cord-010119-t1x9gknd 11457 17 in in IN cord-010119-t1x9gknd 11457 18 platelet platelet NN cord-010119-t1x9gknd 11457 19 function function NN cord-010119-t1x9gknd 11457 20 after after IN cord-010119-t1x9gknd 11457 21 filtering filter VBG cord-010119-t1x9gknd 11457 22 leukocytes leukocyte NNS cord-010119-t1x9gknd 11457 23 with with IN cord-010119-t1x9gknd 11457 24 leukocytes leukocyte NNS cord-010119-t1x9gknd 11457 25 filter filter NN cord-010119-t1x9gknd 11457 26 for for IN cord-010119-t1x9gknd 11457 27 PCs pc NNS cord-010119-t1x9gknd 11457 28 and and CC cord-010119-t1x9gknd 11457 29 the the DT cord-010119-t1x9gknd 11457 30 quality quality NN cord-010119-t1x9gknd 11457 31 changes change NNS cord-010119-t1x9gknd 11457 32 during during IN cord-010119-t1x9gknd 11457 33 storage storage NN cord-010119-t1x9gknd 11457 34 in in IN cord-010119-t1x9gknd 11457 35 PVC pvc NN cord-010119-t1x9gknd 11457 36 - - HYPH cord-010119-t1x9gknd 11457 37 BTHC BTHC NNP cord-010119-t1x9gknd 11457 38 blood blood NN cord-010119-t1x9gknd 11457 39 bags bag NNS cord-010119-t1x9gknd 11457 40 . . . cord-010119-t1x9gknd 11458 1 Study Study NNP cord-010119-t1x9gknd 11458 2 Design Design NNP cord-010119-t1x9gknd 11458 3 / / SYM cord-010119-t1x9gknd 11458 4 Method method NN cord-010119-t1x9gknd 11458 5 : : : cord-010119-t1x9gknd 11458 6 PCs pc NNS cord-010119-t1x9gknd 11458 7 were be VBD cord-010119-t1x9gknd 11458 8 prepared prepare VBN cord-010119-t1x9gknd 11458 9 from from IN cord-010119-t1x9gknd 11458 10 400 400 CD cord-010119-t1x9gknd 11458 11 mL ml NN cord-010119-t1x9gknd 11458 12 virus virus NN cord-010119-t1x9gknd 11458 13 free free JJ cord-010119-t1x9gknd 11458 14 whole whole JJ cord-010119-t1x9gknd 11458 15 blood blood NN cord-010119-t1x9gknd 11458 16 by by IN cord-010119-t1x9gknd 11458 17 platelet platelet NN cord-010119-t1x9gknd 11458 18 - - HYPH cord-010119-t1x9gknd 11458 19 rich rich JJ cord-010119-t1x9gknd 11458 20 plasma plasma NN cord-010119-t1x9gknd 11458 21 ( ( -LRB- cord-010119-t1x9gknd 11458 22 PRP prp NN cord-010119-t1x9gknd 11458 23 ) ) -RRB- cord-010119-t1x9gknd 11458 24 method method NN cord-010119-t1x9gknd 11458 25 . . . cord-010119-t1x9gknd 11459 1 Five five CD cord-010119-t1x9gknd 11459 2 or or CC cord-010119-t1x9gknd 11459 3 six six CD cord-010119-t1x9gknd 11459 4 bags bag NNS cord-010119-t1x9gknd 11459 5 of of IN cord-010119-t1x9gknd 11459 6 ABOmatched ABOmatched NNP cord-010119-t1x9gknd 11459 7 PCs pc NNS cord-010119-t1x9gknd 11459 8 were be VBD cord-010119-t1x9gknd 11459 9 pooled pool VBN cord-010119-t1x9gknd 11459 10 and and CC cord-010119-t1x9gknd 11459 11 filtered filter VBN cord-010119-t1x9gknd 11459 12 with with IN cord-010119-t1x9gknd 11459 13 leukocytes leukocyte NNS cord-010119-t1x9gknd 11459 14 filter filter NN cord-010119-t1x9gknd 11459 15 for for IN cord-010119-t1x9gknd 11459 16 PCs(n57 PCs(n57 NNP cord-010119-t1x9gknd 11459 17 ) ) -RRB- cord-010119-t1x9gknd 11459 18 . . . cord-010119-t1x9gknd 11460 1 The the DT cord-010119-t1x9gknd 11460 2 swirling swirl VBG cord-010119-t1x9gknd 11460 3 phenomenon phenomenon NN cord-010119-t1x9gknd 11460 4 , , , cord-010119-t1x9gknd 11460 5 pH pH NNP cord-010119-t1x9gknd 11460 6 , , , cord-010119-t1x9gknd 11460 7 automatic automatic JJ cord-010119-t1x9gknd 11460 8 blood blood NN cord-010119-t1x9gknd 11460 9 count count NN cord-010119-t1x9gknd 11460 10 , , , cord-010119-t1x9gknd 11460 11 platelet platelet NN cord-010119-t1x9gknd 11460 12 aggregation aggregation NN cord-010119-t1x9gknd 11460 13 , , , cord-010119-t1x9gknd 11460 14 hypotonic hypotonic JJ cord-010119-t1x9gknd 11460 15 shock shock NN cord-010119-t1x9gknd 11460 16 response response NN cord-010119-t1x9gknd 11460 17 ( ( -LRB- cord-010119-t1x9gknd 11460 18 HSR HSR NNP cord-010119-t1x9gknd 11460 19 ) ) -RRB- cord-010119-t1x9gknd 11460 20 , , , cord-010119-t1x9gknd 11460 21 the the DT cord-010119-t1x9gknd 11460 22 extent extent NN cord-010119-t1x9gknd 11460 23 of of IN cord-010119-t1x9gknd 11460 24 shape shape NN cord-010119-t1x9gknd 11460 25 change(ESC change(ESC NNP cord-010119-t1x9gknd 11460 26 ) ) -RRB- cord-010119-t1x9gknd 11460 27 , , , cord-010119-t1x9gknd 11460 28 CD62p CD62p NNP cord-010119-t1x9gknd 11460 29 expression expression NN cord-010119-t1x9gknd 11460 30 , , , cord-010119-t1x9gknd 11460 31 ATP ATP NNP cord-010119-t1x9gknd 11460 32 level level NN cord-010119-t1x9gknd 11460 33 in in IN cord-010119-t1x9gknd 11460 34 platelet platelet NN cord-010119-t1x9gknd 11460 35 , , , cord-010119-t1x9gknd 11460 36 glucose glucose NN cord-010119-t1x9gknd 11460 37 and and CC cord-010119-t1x9gknd 11460 38 lactate lactate NN cord-010119-t1x9gknd 11460 39 concentration concentration NN cord-010119-t1x9gknd 11460 40 were be VBD cord-010119-t1x9gknd 11460 41 detected detect VBN cord-010119-t1x9gknd 11460 42 before before IN cord-010119-t1x9gknd 11460 43 and and CC cord-010119-t1x9gknd 11460 44 after after IN cord-010119-t1x9gknd 11460 45 filtering filter VBG cord-010119-t1x9gknd 11460 46 , , , cord-010119-t1x9gknd 11460 47 and and CC cord-010119-t1x9gknd 11460 48 on on IN cord-010119-t1x9gknd 11460 49 days1 days1 NN cord-010119-t1x9gknd 11460 50 , , , cord-010119-t1x9gknd 11460 51 3 3 CD cord-010119-t1x9gknd 11460 52 , , , cord-010119-t1x9gknd 11460 53 5 5 CD cord-010119-t1x9gknd 11460 54 and and CC cord-010119-t1x9gknd 11460 55 7 7 CD cord-010119-t1x9gknd 11460 56 of of IN cord-010119-t1x9gknd 11460 57 storage storage NN cord-010119-t1x9gknd 11460 58 , , , cord-010119-t1x9gknd 11460 59 respectively respectively RB cord-010119-t1x9gknd 11460 60 . . . cord-010119-t1x9gknd 11461 1 Results/ Results/ . cord-010119-t1x9gknd 11462 1 Finding finding NN cord-010119-t1x9gknd 11462 2 : : : cord-010119-t1x9gknd 11463 1 The the DT cord-010119-t1x9gknd 11463 2 platelet platelet NN cord-010119-t1x9gknd 11463 3 recovery recovery NN cord-010119-t1x9gknd 11463 4 ratio ratio NN cord-010119-t1x9gknd 11463 5 of of IN cord-010119-t1x9gknd 11463 6 a a DT cord-010119-t1x9gknd 11463 7 therapeutic therapeutic JJ cord-010119-t1x9gknd 11463 8 dose dose NN cord-010119-t1x9gknd 11463 9 of of IN cord-010119-t1x9gknd 11463 10 pooled pool VBN cord-010119-t1x9gknd 11463 11 platelet platelet NN cord-010119-t1x9gknd 11463 12 concentrates concentrate VBZ cord-010119-t1x9gknd 11463 13 after after IN cord-010119-t1x9gknd 11463 14 filtering filter VBG cord-010119-t1x9gknd 11463 15 leukocytes leukocyte NNS cord-010119-t1x9gknd 11463 16 was be VBD cord-010119-t1x9gknd 11463 17 ( ( -LRB- cord-010119-t1x9gknd 11463 18 86.7 86.7 CD cord-010119-t1x9gknd 11463 19 6 6 CD cord-010119-t1x9gknd 11463 20 1.6)% 1.6)% CD cord-010119-t1x9gknd 11463 21 , , , cord-010119-t1x9gknd 11463 22 relative relative JJ cord-010119-t1x9gknd 11463 23 change change NN cord-010119-t1x9gknd 11463 24 rate rate NN cord-010119-t1x9gknd 11463 25 of of IN cord-010119-t1x9gknd 11463 26 HSR HSR NNP cord-010119-t1x9gknd 11463 27 was be VBD cord-010119-t1x9gknd 11463 28 ( ( -LRB- cord-010119-t1x9gknd 11463 29 3.87 3.87 CD cord-010119-t1x9gknd 11463 30 6 6 CD cord-010119-t1x9gknd 11463 31 12.75)% 12.75)% CD cord-010119-t1x9gknd 11463 32 , , , cord-010119-t1x9gknd 11463 33 the the DT cord-010119-t1x9gknd 11463 34 residual residual JJ cord-010119-t1x9gknd 11463 35 leukocytes leukocyte NNS cord-010119-t1x9gknd 11463 36 were be VBD cord-010119-t1x9gknd 11463 37 ( ( -LRB- cord-010119-t1x9gknd 11463 38 0.15 0.15 CD cord-010119-t1x9gknd 11463 39 6 6 CD cord-010119-t1x9gknd 11463 40 0.15)310 0.15)310 CD cord-010119-t1x9gknd 11463 41 6 6 CD cord-010119-t1x9gknd 11463 42 . . . cord-010119-t1x9gknd 11464 1 The the DT cord-010119-t1x9gknd 11464 2 pH pH NNP cord-010119-t1x9gknd 11464 3 , , , cord-010119-t1x9gknd 11464 4 HSR HSR NNP cord-010119-t1x9gknd 11464 5 , , , cord-010119-t1x9gknd 11464 6 and and CC cord-010119-t1x9gknd 11464 7 the the DT cord-010119-t1x9gknd 11464 8 CD62p CD62p NNP cord-010119-t1x9gknd 11464 9 expression expression NN cord-010119-t1x9gknd 11464 10 of of IN cord-010119-t1x9gknd 11464 11 pooled pool VBN cord-010119-t1x9gknd 11464 12 platelet platelet NN cord-010119-t1x9gknd 11464 13 concentrates concentrate VBZ cord-010119-t1x9gknd 11464 14 before before RB cord-010119-t1x9gknd 11464 15 and and CC cord-010119-t1x9gknd 11465 1 after after IN cord-010119-t1x9gknd 11465 2 filtering filter VBG cord-010119-t1x9gknd 11465 3 were be VBD cord-010119-t1x9gknd 11465 4 ( ( -LRB- cord-010119-t1x9gknd 11465 5 7.00 7.00 CD cord-010119-t1x9gknd 11465 6 6 6 CD cord-010119-t1x9gknd 11465 7 0.17 0.17 CD cord-010119-t1x9gknd 11465 8 ) ) -RRB- cord-010119-t1x9gknd 11466 1 vs vs IN cord-010119-t1x9gknd 11466 2 ( ( -LRB- cord-010119-t1x9gknd 11466 3 7.06 7.06 CD cord-010119-t1x9gknd 11466 4 6 6 CD cord-010119-t1x9gknd 11466 5 0.16 0.16 CD cord-010119-t1x9gknd 11466 6 ) ) -RRB- cord-010119-t1x9gknd 11466 7 , , , cord-010119-t1x9gknd 11466 8 ( ( -LRB- cord-010119-t1x9gknd 11466 9 66.96 66.96 CD cord-010119-t1x9gknd 11466 10 6 6 CD cord-010119-t1x9gknd 11466 11 12.35)% 12.35)% CD cord-010119-t1x9gknd 11466 12 vs vs IN cord-010119-t1x9gknd 11466 13 ( ( -LRB- cord-010119-t1x9gknd 11466 14 63.22 63.22 CD cord-010119-t1x9gknd 11466 15 6 6 CD cord-010119-t1x9gknd 11466 16 8.26)% 8.26)% CD cord-010119-t1x9gknd 11466 17 and and CC cord-010119-t1x9gknd 11466 18 ( ( -LRB- cord-010119-t1x9gknd 11466 19 28.94 28.94 CD cord-010119-t1x9gknd 11466 20 6 6 CD cord-010119-t1x9gknd 11466 21 14.25 14.25 CD cord-010119-t1x9gknd 11466 22 ) ) -RRB- cord-010119-t1x9gknd 11466 23 % % NN cord-010119-t1x9gknd 11466 24 vs vs IN cord-010119-t1x9gknd 11466 25 ( ( -LRB- cord-010119-t1x9gknd 11466 26 31.60 31.60 CD cord-010119-t1x9gknd 11466 27 6 6 CD cord-010119-t1x9gknd 11466 28 16.77)% 16.77)% CD cord-010119-t1x9gknd 11466 29 . . . cord-010119-t1x9gknd 11467 1 There there EX cord-010119-t1x9gknd 11467 2 is be VBZ cord-010119-t1x9gknd 11467 3 significant significant JJ cord-010119-t1x9gknd 11467 4 change change NN cord-010119-t1x9gknd 11467 5 for for IN cord-010119-t1x9gknd 11467 6 WBC WBC NNP cord-010119-t1x9gknd 11467 7 after after IN cord-010119-t1x9gknd 11467 8 filtering filter VBG cord-010119-t1x9gknd 11467 9 ( ( -LRB- cord-010119-t1x9gknd 11467 10 P<0.01 P<0.01 NNP cord-010119-t1x9gknd 11467 11 ) ) -RRB- cord-010119-t1x9gknd 11467 12 . . . cord-010119-t1x9gknd 11468 1 During during IN cord-010119-t1x9gknd 11468 2 storage storage NN cord-010119-t1x9gknd 11468 3 in in IN cord-010119-t1x9gknd 11468 4 PVC pvc NN cord-010119-t1x9gknd 11468 5 - - HYPH cord-010119-t1x9gknd 11468 6 BTHC BTHC NNP cord-010119-t1x9gknd 11468 7 blood blood NN cord-010119-t1x9gknd 11468 8 bags bag NNS cord-010119-t1x9gknd 11468 9 , , , cord-010119-t1x9gknd 11468 10 the the DT cord-010119-t1x9gknd 11468 11 biochemical biochemical JJ cord-010119-t1x9gknd 11468 12 parameters parameter NNS cord-010119-t1x9gknd 11468 13 of of IN cord-010119-t1x9gknd 11468 14 pooled pool VBN cord-010119-t1x9gknd 11468 15 platelet platelet NN cord-010119-t1x9gknd 11468 16 concentrates concentrate VBZ cord-010119-t1x9gknd 11468 17 changed change VBN cord-010119-t1x9gknd 11468 18 with with IN cord-010119-t1x9gknd 11468 19 increasing increase VBG cord-010119-t1x9gknd 11468 20 storage storage NN cord-010119-t1x9gknd 11468 21 time time NN cord-010119-t1x9gknd 11468 22 , , , cord-010119-t1x9gknd 11468 23 as as IN cord-010119-t1x9gknd 11468 24 shown show VBN cord-010119-t1x9gknd 11468 25 in in IN cord-010119-t1x9gknd 11468 26 table table NN cord-010119-t1x9gknd 11468 27 1 1 CD cord-010119-t1x9gknd 11468 28 . . . cord-010119-t1x9gknd 11469 1 Conclusion conclusion NN cord-010119-t1x9gknd 11469 2 : : : cord-010119-t1x9gknd 11469 3 Storage storage NN cord-010119-t1x9gknd 11469 4 in in IN cord-010119-t1x9gknd 11469 5 PVC pvc NN cord-010119-t1x9gknd 11469 6 - - HYPH cord-010119-t1x9gknd 11469 7 BTHC BTHC NNP cord-010119-t1x9gknd 11469 8 blood blood NN cord-010119-t1x9gknd 11469 9 bags bag NNS cord-010119-t1x9gknd 11469 10 for for IN cord-010119-t1x9gknd 11469 11 five five CD cord-010119-t1x9gknd 11469 12 days day NNS cord-010119-t1x9gknd 11470 1 , , , cord-010119-t1x9gknd 11470 2 the the DT cord-010119-t1x9gknd 11470 3 quality quality NN cord-010119-t1x9gknd 11470 4 of of IN cord-010119-t1x9gknd 11470 5 pooled pool VBN cord-010119-t1x9gknd 11470 6 PCs pc NNS cord-010119-t1x9gknd 11470 7 met meet VBD cord-010119-t1x9gknd 11470 8 the the DT cord-010119-t1x9gknd 11470 9 requirements requirement NNS cord-010119-t1x9gknd 11470 10 of of IN cord-010119-t1x9gknd 11470 11 Chinese chinese JJ cord-010119-t1x9gknd 11470 12 standards standard NNS cord-010119-t1x9gknd 11470 13 ( ( -LRB- cord-010119-t1x9gknd 11470 14 GB GB NNP cord-010119-t1x9gknd 11470 15 18469 18469 CD cord-010119-t1x9gknd 11470 16 - - HYPH cord-010119-t1x9gknd 11470 17 2012 2012 CD cord-010119-t1x9gknd 11470 18 ) ) -RRB- cord-010119-t1x9gknd 11470 19 . . . cord-010119-t1x9gknd 11471 1 It -PRON- PRP cord-010119-t1x9gknd 11471 2 can can MD cord-010119-t1x9gknd 11471 3 be be VB cord-010119-t1x9gknd 11471 4 a a DT cord-010119-t1x9gknd 11471 5 complementary complementary JJ cord-010119-t1x9gknd 11471 6 source source NN cord-010119-t1x9gknd 11471 7 for for IN cord-010119-t1x9gknd 11471 8 apheresis apheresis NN cord-010119-t1x9gknd 11471 9 platelets platelet NNS cord-010119-t1x9gknd 11471 10 supplement supplement NN cord-010119-t1x9gknd 11471 11 in in IN cord-010119-t1x9gknd 11471 12 China China NNP cord-010119-t1x9gknd 11471 13 . . . cord-010119-t1x9gknd 11472 1 Evaluation evaluation NN cord-010119-t1x9gknd 11472 2 of of IN cord-010119-t1x9gknd 11472 3 SamplokV SamplokV NNP cord-010119-t1x9gknd 11472 4 R R NNP cord-010119-t1x9gknd 11472 5 Segment Segment NNP cord-010119-t1x9gknd 11472 6 Sampler Sampler NNP cord-010119-t1x9gknd 11472 7 to to TO cord-010119-t1x9gknd 11472 8 Obtain obtain VB cord-010119-t1x9gknd 11472 9 and and CC cord-010119-t1x9gknd 11472 10 Measure measure VB cord-010119-t1x9gknd 11472 11 Samples sample NNS cord-010119-t1x9gknd 11472 12 from from IN cord-010119-t1x9gknd 11472 13 Blood blood NN cord-010119-t1x9gknd 11472 14 Component component NN cord-010119-t1x9gknd 11472 15 Tubing Tubing NNP cord-010119-t1x9gknd 11472 16 Segments Segments NNP cord-010119-t1x9gknd 11472 17 Abbejane Abbejane NNP cord-010119-t1x9gknd 11472 18 Blair Blair NNP cord-010119-t1x9gknd 11473 1 * * NFP cord-010119-t1x9gknd 11473 2 . . . cord-010119-t1x9gknd 11474 1 AJBlair AJBlair NNP cord-010119-t1x9gknd 11474 2 Laboratory Laboratory NNP cord-010119-t1x9gknd 11474 3 Consulting Consulting NNP cord-010119-t1x9gknd 11474 4 Background Background NNP cord-010119-t1x9gknd 11474 5 / / SYM cord-010119-t1x9gknd 11474 6 Case Case NNP cord-010119-t1x9gknd 11474 7 Studies Studies NNPS cord-010119-t1x9gknd 11474 8 : : : cord-010119-t1x9gknd 11475 1 Current current JJ cord-010119-t1x9gknd 11475 2 methods method NNS cord-010119-t1x9gknd 11475 3 used use VBN cord-010119-t1x9gknd 11475 4 to to TO cord-010119-t1x9gknd 11475 5 obtain obtain VB cord-010119-t1x9gknd 11475 6 samples sample NNS cord-010119-t1x9gknd 11475 7 from from IN cord-010119-t1x9gknd 11475 8 blood blood NN cord-010119-t1x9gknd 11475 9 component component NN cord-010119-t1x9gknd 11475 10 tubing tubing NN cord-010119-t1x9gknd 11475 11 segments segment NNS cord-010119-t1x9gknd 11475 12 are be VBP cord-010119-t1x9gknd 11475 13 cumbersome cumbersome JJ cord-010119-t1x9gknd 11475 14 and and CC cord-010119-t1x9gknd 11475 15 present present VBP cord-010119-t1x9gknd 11475 16 a a DT cord-010119-t1x9gknd 11475 17 significant significant JJ cord-010119-t1x9gknd 11475 18 risk risk NN cord-010119-t1x9gknd 11475 19 for for IN cord-010119-t1x9gknd 11475 20 exposure exposure NN cord-010119-t1x9gknd 11475 21 to to IN cord-010119-t1x9gknd 11475 22 biohazards biohazard NNS cord-010119-t1x9gknd 11475 23 , , , cord-010119-t1x9gknd 11475 24 sharps sharps NNP cord-010119-t1x9gknd 11475 25 injury injury NN cord-010119-t1x9gknd 11475 26 and and CC cord-010119-t1x9gknd 11475 27 cross cross NN cord-010119-t1x9gknd 11475 28 contamination contamination NN cord-010119-t1x9gknd 11475 29 . . . cord-010119-t1x9gknd 11476 1 ITL ITL NNP cord-010119-t1x9gknd 11476 2 BioMedical BioMedical NNP cord-010119-t1x9gknd 11476 3 has have VBZ cord-010119-t1x9gknd 11476 4 developed develop VBN cord-010119-t1x9gknd 11476 5 SampLokV SampLokV NNP cord-010119-t1x9gknd 11476 6 R R NNP cord-010119-t1x9gknd 11476 7 Segment Segment NNP cord-010119-t1x9gknd 11476 8 Sampler Sampler NNP cord-010119-t1x9gknd 11476 9 ( ( -LRB- cord-010119-t1x9gknd 11476 10 SS SS NNP cord-010119-t1x9gknd 11476 11 ) ) -RRB- cord-010119-t1x9gknd 11476 12 , , , cord-010119-t1x9gknd 11476 13 a a DT cord-010119-t1x9gknd 11476 14 device device NN cord-010119-t1x9gknd 11476 15 for for IN cord-010119-t1x9gknd 11476 16 obtaining obtain VBG cord-010119-t1x9gknd 11476 17 measured measure VBN cord-010119-t1x9gknd 11476 18 samples sample NNS cord-010119-t1x9gknd 11476 19 from from IN cord-010119-t1x9gknd 11476 20 sealed sealed JJ cord-010119-t1x9gknd 11476 21 tubing tubing NN cord-010119-t1x9gknd 11476 22 segments segment NNS cord-010119-t1x9gknd 11476 23 that that WDT cord-010119-t1x9gknd 11476 24 is be VBZ cord-010119-t1x9gknd 11476 25 less less RBR cord-010119-t1x9gknd 11476 26 cumbersome cumbersome JJ cord-010119-t1x9gknd 11476 27 and and CC cord-010119-t1x9gknd 11476 28 offers offer VBZ cord-010119-t1x9gknd 11476 29 improved improved JJ cord-010119-t1x9gknd 11476 30 safety safety NN cord-010119-t1x9gknd 11476 31 , , , cord-010119-t1x9gknd 11476 32 eliminating eliminate VBG cord-010119-t1x9gknd 11476 33 the the DT cord-010119-t1x9gknd 11476 34 need need NN cord-010119-t1x9gknd 11476 35 to to TO cord-010119-t1x9gknd 11476 36 manually manually RB cord-010119-t1x9gknd 11476 37 cut cut VB cord-010119-t1x9gknd 11476 38 and and CC cord-010119-t1x9gknd 11476 39 squeeze squeeze VB cord-010119-t1x9gknd 11476 40 tubing tubing NN cord-010119-t1x9gknd 11476 41 segments segment NNS cord-010119-t1x9gknd 11476 42 . . . cord-010119-t1x9gknd 11477 1 SS SS NNP cord-010119-t1x9gknd 11477 2 was be VBD cord-010119-t1x9gknd 11477 3 evaluated evaluate VBN cord-010119-t1x9gknd 11477 4 with with IN cord-010119-t1x9gknd 11477 5 the the DT cord-010119-t1x9gknd 11477 6 goals goal NNS cord-010119-t1x9gknd 11477 7 of of IN cord-010119-t1x9gknd 11477 8 reducing reduce VBG cord-010119-t1x9gknd 11477 9 the the DT cord-010119-t1x9gknd 11477 10 number number NN cord-010119-t1x9gknd 11477 11 of of IN cord-010119-t1x9gknd 11477 12 steps step NNS cord-010119-t1x9gknd 11477 13 required require VBN cord-010119-t1x9gknd 11477 14 to to TO cord-010119-t1x9gknd 11477 15 obtain obtain VB cord-010119-t1x9gknd 11477 16 a a DT cord-010119-t1x9gknd 11477 17 measured measure VBN cord-010119-t1x9gknd 11477 18 sample sample NN cord-010119-t1x9gknd 11477 19 , , , cord-010119-t1x9gknd 11477 20 and and CC cord-010119-t1x9gknd 11477 21 , , , cord-010119-t1x9gknd 11477 22 reduce reduce VB cord-010119-t1x9gknd 11477 23 biohazards biohazard NNS cord-010119-t1x9gknd 11477 24 and and CC cord-010119-t1x9gknd 11477 25 sharps sharps NN cord-010119-t1x9gknd 11477 26 exposure exposure NN cord-010119-t1x9gknd 11477 27 . . . cord-010119-t1x9gknd 11478 1 Study Study NNP cord-010119-t1x9gknd 11478 2 Design Design NNP cord-010119-t1x9gknd 11478 3 / / SYM cord-010119-t1x9gknd 11478 4 Method method NN cord-010119-t1x9gknd 11478 5 : : : cord-010119-t1x9gknd 11478 6 SS SS NNP cord-010119-t1x9gknd 11478 7 obtains obtain VBZ cord-010119-t1x9gknd 11478 8 fluid fluid JJ cord-010119-t1x9gknd 11478 9 samples sample NNS cord-010119-t1x9gknd 11478 10 from from IN cord-010119-t1x9gknd 11478 11 sealed sealed JJ cord-010119-t1x9gknd 11478 12 tubing tubing NN cord-010119-t1x9gknd 11478 13 segments segment NNS cord-010119-t1x9gknd 11478 14 into into IN cord-010119-t1x9gknd 11478 15 a a DT cord-010119-t1x9gknd 11478 16 needleless needleless NN cord-010119-t1x9gknd 11478 17 syringe syringe NN cord-010119-t1x9gknd 11478 18 . . . cord-010119-t1x9gknd 11479 1 It -PRON- PRP cord-010119-t1x9gknd 11479 2 consists consist VBZ cord-010119-t1x9gknd 11479 3 of of IN cord-010119-t1x9gknd 11479 4 two two CD cord-010119-t1x9gknd 11479 5 chambers chamber NNS cord-010119-t1x9gknd 11479 6 with with IN cord-010119-t1x9gknd 11479 7 recessed recess VBN cord-010119-t1x9gknd 11479 8 internal internal JJ cord-010119-t1x9gknd 11479 9 needles needle NNS cord-010119-t1x9gknd 11479 10 located locate VBN cord-010119-t1x9gknd 11479 11 at at IN cord-010119-t1x9gknd 11479 12 the the DT cord-010119-t1x9gknd 11479 13 top top NN cord-010119-t1x9gknd 11479 14 of of IN cord-010119-t1x9gknd 11479 15 the the DT cord-010119-t1x9gknd 11479 16 device device NN cord-010119-t1x9gknd 11479 17 and and CC cord-010119-t1x9gknd 11479 18 a a DT cord-010119-t1x9gknd 11479 19 female female JJ cord-010119-t1x9gknd 11479 20 port port NN cord-010119-t1x9gknd 11479 21 located locate VBN cord-010119-t1x9gknd 11479 22 at at IN cord-010119-t1x9gknd 11479 23 the the DT cord-010119-t1x9gknd 11479 24 bottom bottom NN cord-010119-t1x9gknd 11479 25 of of IN cord-010119-t1x9gknd 11479 26 the the DT cord-010119-t1x9gknd 11479 27 device device NN cord-010119-t1x9gknd 11479 28 . . . cord-010119-t1x9gknd 11480 1 A a DT cord-010119-t1x9gknd 11480 2 needleless needleless NN cord-010119-t1x9gknd 11480 3 syringe syringe NN cord-010119-t1x9gknd 11480 4 is be VBZ cord-010119-t1x9gknd 11480 5 attached attach VBN cord-010119-t1x9gknd 11480 6 to to IN cord-010119-t1x9gknd 11480 7 the the DT cord-010119-t1x9gknd 11480 8 female female JJ cord-010119-t1x9gknd 11480 9 port port NN cord-010119-t1x9gknd 11480 10 , , , cord-010119-t1x9gknd 11480 11 the the DT cord-010119-t1x9gknd 11480 12 sealed seal VBN cord-010119-t1x9gknd 11480 13 tubing tubing NN cord-010119-t1x9gknd 11480 14 ends end NNS cord-010119-t1x9gknd 11480 15 are be VBP cord-010119-t1x9gknd 11480 16 then then RB cord-010119-t1x9gknd 11480 17 aligned align VBN cord-010119-t1x9gknd 11480 18 with with IN cord-010119-t1x9gknd 11480 19 the the DT cord-010119-t1x9gknd 11480 20 SS SS NNP cord-010119-t1x9gknd 11480 21 chambers chamber NNS cord-010119-t1x9gknd 11480 22 and and CC cord-010119-t1x9gknd 11480 23 , , , cord-010119-t1x9gknd 11480 24 gently gently RB cord-010119-t1x9gknd 11480 25 pushed push VBD cord-010119-t1x9gknd 11480 26 onto onto IN cord-010119-t1x9gknd 11480 27 the the DT cord-010119-t1x9gknd 11480 28 needles needle NNS cord-010119-t1x9gknd 11480 29 to to TO cord-010119-t1x9gknd 11480 30 pierce pierce VB cord-010119-t1x9gknd 11480 31 each each DT cord-010119-t1x9gknd 11480 32 end end NN cord-010119-t1x9gknd 11480 33 of of IN cord-010119-t1x9gknd 11480 34 the the DT cord-010119-t1x9gknd 11480 35 segment segment NN cord-010119-t1x9gknd 11480 36 . . . cord-010119-t1x9gknd 11481 1 The the DT cord-010119-t1x9gknd 11481 2 sample sample NN cord-010119-t1x9gknd 11481 3 from from IN cord-010119-t1x9gknd 11481 4 the the DT cord-010119-t1x9gknd 11481 5 segment segment NN cord-010119-t1x9gknd 11481 6 is be VBZ cord-010119-t1x9gknd 11481 7 then then RB cord-010119-t1x9gknd 11481 8 withdrawn withdraw VBN cord-010119-t1x9gknd 11481 9 into into IN cord-010119-t1x9gknd 11481 10 the the DT cord-010119-t1x9gknd 11481 11 syringe syringe NN cord-010119-t1x9gknd 11481 12 . . . cord-010119-t1x9gknd 11482 1 The the DT cord-010119-t1x9gknd 11482 2 study study NN cord-010119-t1x9gknd 11482 3 was be VBD cord-010119-t1x9gknd 11482 4 performed perform VBN cord-010119-t1x9gknd 11482 5 at at IN cord-010119-t1x9gknd 11482 6 Rhode Rhode NNP cord-010119-t1x9gknd 11482 7 Island Island NNP cord-010119-t1x9gknd 11482 8 Blood Blood NNP cord-010119-t1x9gknd 11482 9 Center Center NNP cord-010119-t1x9gknd 11482 10 ( ( -LRB- cord-010119-t1x9gknd 11482 11 Providence Providence NNP cord-010119-t1x9gknd 11482 12 , , , cord-010119-t1x9gknd 11482 13 RI RI NNP cord-010119-t1x9gknd 11482 14 ) ) -RRB- cord-010119-t1x9gknd 11482 15 using use VBG cord-010119-t1x9gknd 11482 16 tubing tubing NN cord-010119-t1x9gknd 11482 17 segments segment NNS cord-010119-t1x9gknd 11482 18 from from IN cord-010119-t1x9gknd 11482 19 three three CD cord-010119-t1x9gknd 11482 20 bag bag NN cord-010119-t1x9gknd 11482 21 manufacturers manufacturer NNS cord-010119-t1x9gknd 11482 22 to to TO cord-010119-t1x9gknd 11482 23 demonstrate demonstrate VB cord-010119-t1x9gknd 11482 24 ease ease NN cord-010119-t1x9gknd 11482 25 of of IN cord-010119-t1x9gknd 11482 26 use use NN cord-010119-t1x9gknd 11482 27 on on IN cord-010119-t1x9gknd 11482 28 the the DT cord-010119-t1x9gknd 11482 29 following follow VBG cord-010119-t1x9gknd 11482 30 processes process NNS cord-010119-t1x9gknd 11482 31 : : : cord-010119-t1x9gknd 11482 32 segment segment NN cord-010119-t1x9gknd 11482 33 alignment alignment NN cord-010119-t1x9gknd 11482 34 over over IN cord-010119-t1x9gknd 11482 35 needles needle NNS cord-010119-t1x9gknd 11482 36 and and CC cord-010119-t1x9gknd 11482 37 piercing piercing NN cord-010119-t1x9gknd 11482 38 , , , cord-010119-t1x9gknd 11482 39 ability ability NN cord-010119-t1x9gknd 11482 40 to to TO cord-010119-t1x9gknd 11482 41 draw draw VB cord-010119-t1x9gknd 11482 42 sample sample NN cord-010119-t1x9gknd 11482 43 into into IN cord-010119-t1x9gknd 11482 44 syringe syringe NN cord-010119-t1x9gknd 11482 45 , , , cord-010119-t1x9gknd 11482 46 ability ability NN cord-010119-t1x9gknd 11482 47 to to TO cord-010119-t1x9gknd 11482 48 expel expel VB cord-010119-t1x9gknd 11482 49 air air NN cord-010119-t1x9gknd 11482 50 bubbles bubble NNS cord-010119-t1x9gknd 11482 51 from from IN cord-010119-t1x9gknd 11482 52 syringe syringe NN cord-010119-t1x9gknd 11482 53 , , , cord-010119-t1x9gknd 11482 54 fluid fluid JJ cord-010119-t1x9gknd 11482 55 leaks leak NNS cord-010119-t1x9gknd 11482 56 , , , cord-010119-t1x9gknd 11482 57 ease ease NN cord-010119-t1x9gknd 11482 58 of of IN cord-010119-t1x9gknd 11482 59 transfer transfer NN cord-010119-t1x9gknd 11482 60 of of IN cord-010119-t1x9gknd 11482 61 sample sample NN cord-010119-t1x9gknd 11482 62 from from IN cord-010119-t1x9gknd 11482 63 syringe syringe NN cord-010119-t1x9gknd 11482 64 to to IN cord-010119-t1x9gknd 11482 65 tube tube NN cord-010119-t1x9gknd 11482 66 and and CC cord-010119-t1x9gknd 11482 67 to to TO cord-010119-t1x9gknd 11482 68 collect collect VB cord-010119-t1x9gknd 11482 69 user user NN cord-010119-t1x9gknd 11482 70 feedback feedback NN cord-010119-t1x9gknd 11482 71 . . . cord-010119-t1x9gknd 11483 1 Two two CD cord-010119-t1x9gknd 11483 2 lengths length NNS cord-010119-t1x9gknd 11483 3 of of IN cord-010119-t1x9gknd 11483 4 tubing tubing NN cord-010119-t1x9gknd 11483 5 segments segment NNS cord-010119-t1x9gknd 11483 6 were be VBD cord-010119-t1x9gknd 11483 7 filled fill VBN cord-010119-t1x9gknd 11483 8 to to TO cord-010119-t1x9gknd 11483 9 contain contain VB cord-010119-t1x9gknd 11483 10 sample sample NN cord-010119-t1x9gknd 11483 11 volumes volume NNS cord-010119-t1x9gknd 11483 12 of of IN cord-010119-t1x9gknd 11483 13 500mL 500ml NN cord-010119-t1x9gknd 11483 14 and and CC cord-010119-t1x9gknd 11484 1 1000mL. 1000ml. LS cord-010119-t1x9gknd 11484 2 Two two CD cord-010119-t1x9gknd 11484 3 users user NNS cord-010119-t1x9gknd 11484 4 then then RB cord-010119-t1x9gknd 11484 5 evaluated evaluate VBD cord-010119-t1x9gknd 11484 6 the the DT cord-010119-t1x9gknd 11484 7 SS ss NN cord-010119-t1x9gknd 11484 8 tubing tubing NN cord-010119-t1x9gknd 11484 9 segment segment NN cord-010119-t1x9gknd 11484 10 types type NNS cord-010119-t1x9gknd 11484 11 with with IN cord-010119-t1x9gknd 11484 12 500mL 500ml CD cord-010119-t1x9gknd 11484 13 or or CC cord-010119-t1x9gknd 11484 14 1000mL 1000ml CD cord-010119-t1x9gknd 11484 15 samples sample NNS cord-010119-t1x9gknd 11484 16 for for IN cord-010119-t1x9gknd 11484 17 a a DT cord-010119-t1x9gknd 11484 18 total total NN cord-010119-t1x9gknd 11484 19 of of IN cord-010119-t1x9gknd 11484 20 10 10 CD cord-010119-t1x9gknd 11484 21 data datum NNS cord-010119-t1x9gknd 11484 22 points point NNS cord-010119-t1x9gknd 11484 23 . . . cord-010119-t1x9gknd 11485 1 Samples sample NNS cord-010119-t1x9gknd 11485 2 were be VBD cord-010119-t1x9gknd 11485 3 collected collect VBN cord-010119-t1x9gknd 11485 4 into into IN cord-010119-t1x9gknd 11485 5 the the DT cord-010119-t1x9gknd 11485 6 attached attached JJ cord-010119-t1x9gknd 11485 7 1mL 1ml CD cord-010119-t1x9gknd 11485 8 or or CC cord-010119-t1x9gknd 11485 9 3mL 3ml CD cord-010119-t1x9gknd 11485 10 syringe syringe NN cord-010119-t1x9gknd 11485 11 then then RB cord-010119-t1x9gknd 11485 12 a a DT cord-010119-t1x9gknd 11485 13 measured measure VBN cord-010119-t1x9gknd 11485 14 sample sample NN cord-010119-t1x9gknd 11485 15 was be VBD cord-010119-t1x9gknd 11485 16 transferred transfer VBN cord-010119-t1x9gknd 11485 17 from from IN cord-010119-t1x9gknd 11485 18 the the DT cord-010119-t1x9gknd 11485 19 syringe syringe NN cord-010119-t1x9gknd 11485 20 into into IN cord-010119-t1x9gknd 11485 21 a a DT cord-010119-t1x9gknd 11485 22 test test NN cord-010119-t1x9gknd 11485 23 tube tube NN cord-010119-t1x9gknd 11485 24 or or CC cord-010119-t1x9gknd 11485 25 microcentrifuge microcentrifuge NN cord-010119-t1x9gknd 11485 26 tube tube NN cord-010119-t1x9gknd 11485 27 . . . cord-010119-t1x9gknd 11486 1 Results result NNS cord-010119-t1x9gknd 11486 2 were be VBD cord-010119-t1x9gknd 11486 3 tabulated tabulate VBN cord-010119-t1x9gknd 11486 4 as as IN cord-010119-t1x9gknd 11486 5 PASS pass VB cord-010119-t1x9gknd 11486 6 or or CC cord-010119-t1x9gknd 11486 7 FAIL fail VBP cord-010119-t1x9gknd 11486 8 . . . cord-010119-t1x9gknd 11487 1 Results/ Results/ . cord-010119-t1x9gknd 11488 1 Finding finding NN cord-010119-t1x9gknd 11488 2 : : : cord-010119-t1x9gknd 11488 3 A a DT cord-010119-t1x9gknd 11488 4 total total NN cord-010119-t1x9gknd 11488 5 of of IN cord-010119-t1x9gknd 11488 6 10 10 CD cord-010119-t1x9gknd 11488 7 SS SS NNP cord-010119-t1x9gknd 11488 8 were be VBD cord-010119-t1x9gknd 11488 9 evaluated evaluate VBN cord-010119-t1x9gknd 11488 10 by by IN cord-010119-t1x9gknd 11488 11 two two CD cord-010119-t1x9gknd 11488 12 users user NNS cord-010119-t1x9gknd 11488 13 . . . cord-010119-t1x9gknd 11489 1 All all DT cord-010119-t1x9gknd 11489 2 samples sample NNS cord-010119-t1x9gknd 11489 3 were be VBD cord-010119-t1x9gknd 11489 4 successfully successfully RB cord-010119-t1x9gknd 11489 5 collected collect VBN cord-010119-t1x9gknd 11489 6 and and CC cord-010119-t1x9gknd 11489 7 transferred transfer VBN cord-010119-t1x9gknd 11489 8 into into IN cord-010119-t1x9gknd 11489 9 tubes tube NNS cord-010119-t1x9gknd 11489 10 . . . cord-010119-t1x9gknd 11490 1 Insertion insertion NN cord-010119-t1x9gknd 11490 2 of of IN cord-010119-t1x9gknd 11490 3 the the DT cord-010119-t1x9gknd 11490 4 segment segment NN cord-010119-t1x9gknd 11490 5 edge edge NN cord-010119-t1x9gknd 11490 6 requires require VBZ cord-010119-t1x9gknd 11490 7 observation observation NN cord-010119-t1x9gknd 11490 8 to to TO cord-010119-t1x9gknd 11490 9 ensure ensure VB cord-010119-t1x9gknd 11490 10 placement placement NN cord-010119-t1x9gknd 11490 11 onto onto IN cord-010119-t1x9gknd 11490 12 the the DT cord-010119-t1x9gknd 11490 13 needles needle NNS cord-010119-t1x9gknd 11490 14 . . . cord-010119-t1x9gknd 11491 1 Any any DT cord-010119-t1x9gknd 11491 2 air air NN cord-010119-t1x9gknd 11491 3 bubbles bubble NNS cord-010119-t1x9gknd 11491 4 collected collect VBN cord-010119-t1x9gknd 11491 5 into into IN cord-010119-t1x9gknd 11491 6 the the DT cord-010119-t1x9gknd 11491 7 syringe syringe NN cord-010119-t1x9gknd 11491 8 could could MD cord-010119-t1x9gknd 11491 9 easily easily RB cord-010119-t1x9gknd 11491 10 be be VB cord-010119-t1x9gknd 11491 11 moved move VBN cord-010119-t1x9gknd 11491 12 to to IN cord-010119-t1x9gknd 11491 13 the the DT cord-010119-t1x9gknd 11491 14 top top NN cord-010119-t1x9gknd 11491 15 by by IN cord-010119-t1x9gknd 11491 16 Background Background NNP cord-010119-t1x9gknd 11491 17 / / SYM cord-010119-t1x9gknd 11491 18 Case Case NNP cord-010119-t1x9gknd 11491 19 Studies Studies NNPS cord-010119-t1x9gknd 11491 20 : : : cord-010119-t1x9gknd 11491 21 The the DT cord-010119-t1x9gknd 11491 22 management management NN cord-010119-t1x9gknd 11491 23 of of IN cord-010119-t1x9gknd 11491 24 platelet platelet NN cord-010119-t1x9gknd 11491 25 inventory inventory NN cord-010119-t1x9gknd 11491 26 is be VBZ cord-010119-t1x9gknd 11491 27 crucial crucial JJ cord-010119-t1x9gknd 11491 28 due due IN cord-010119-t1x9gknd 11491 29 to to IN cord-010119-t1x9gknd 11491 30 a a DT cord-010119-t1x9gknd 11491 31 number number NN cord-010119-t1x9gknd 11491 32 of of IN cord-010119-t1x9gknd 11491 33 factors factor NNS cord-010119-t1x9gknd 11491 34 including include VBG cord-010119-t1x9gknd 11491 35 the the DT cord-010119-t1x9gknd 11491 36 5 5 CD cord-010119-t1x9gknd 11491 37 day day NN cord-010119-t1x9gknd 11491 38 product product NN cord-010119-t1x9gknd 11491 39 outdate outdate VBP cord-010119-t1x9gknd 11491 40 , , , cord-010119-t1x9gknd 11491 41 the the DT cord-010119-t1x9gknd 11491 42 allocation allocation NN cord-010119-t1x9gknd 11491 43 of of IN cord-010119-t1x9gknd 11491 44 staff staff NN cord-010119-t1x9gknd 11491 45 due due JJ cord-010119-t1x9gknd 11491 46 to to IN cord-010119-t1x9gknd 11491 47 the the DT cord-010119-t1x9gknd 11491 48 lengthy lengthy JJ cord-010119-t1x9gknd 11491 49 donation donation NN cord-010119-t1x9gknd 11491 50 process process NN cord-010119-t1x9gknd 11491 51 , , , cord-010119-t1x9gknd 11491 52 the the DT cord-010119-t1x9gknd 11491 53 increasingly increasingly RB cord-010119-t1x9gknd 11491 54 small small JJ cord-010119-t1x9gknd 11491 55 donor donor NN cord-010119-t1x9gknd 11491 56 pool pool NN cord-010119-t1x9gknd 11491 57 , , , cord-010119-t1x9gknd 11491 58 and and CC cord-010119-t1x9gknd 11491 59 the the DT cord-010119-t1x9gknd 11491 60 high high JJ cord-010119-t1x9gknd 11491 61 cost cost NN cord-010119-t1x9gknd 11491 62 of of IN cord-010119-t1x9gknd 11491 63 production production NN cord-010119-t1x9gknd 11491 64 ( ( -LRB- cord-010119-t1x9gknd 11491 65 e.g. e.g. IN cord-010119-t1x9gknd 11491 66 platelet platelet NN cord-010119-t1x9gknd 11491 67 collection collection NN cord-010119-t1x9gknd 11491 68 kits kit NNS cord-010119-t1x9gknd 11491 69 , , , cord-010119-t1x9gknd 11491 70 testing testing NN cord-010119-t1x9gknd 11491 71 , , , cord-010119-t1x9gknd 11491 72 product product NN cord-010119-t1x9gknd 11491 73 processing processing NN cord-010119-t1x9gknd 11491 74 ) ) -RRB- cord-010119-t1x9gknd 11491 75 . . . cord-010119-t1x9gknd 11492 1 The the DT cord-010119-t1x9gknd 11492 2 use use NN cord-010119-t1x9gknd 11492 3 of of IN cord-010119-t1x9gknd 11492 4 a a DT cord-010119-t1x9gknd 11492 5 platelet platelet NN cord-010119-t1x9gknd 11492 6 inventory inventory NN cord-010119-t1x9gknd 11492 7 management management NN cord-010119-t1x9gknd 11492 8 tool tool NN cord-010119-t1x9gknd 11492 9 has have VBZ cord-010119-t1x9gknd 11492 10 the the DT cord-010119-t1x9gknd 11492 11 potential potential NN cord-010119-t1x9gknd 11492 12 to to TO cord-010119-t1x9gknd 11492 13 enhance enhance VB cord-010119-t1x9gknd 11492 14 the the DT cord-010119-t1x9gknd 11492 15 understanding understanding NN cord-010119-t1x9gknd 11492 16 of of IN cord-010119-t1x9gknd 11492 17 units unit NNS cord-010119-t1x9gknd 11492 18 transfused transfuse VBN cord-010119-t1x9gknd 11492 19 , , , cord-010119-t1x9gknd 11492 20 optimize optimize VB cord-010119-t1x9gknd 11492 21 inventory inventory NN cord-010119-t1x9gknd 11492 22 , , , cord-010119-t1x9gknd 11492 23 increase increase VB cord-010119-t1x9gknd 11492 24 efficiency efficiency NN cord-010119-t1x9gknd 11492 25 , , , cord-010119-t1x9gknd 11492 26 and and CC cord-010119-t1x9gknd 11492 27 reduce reduce VB cord-010119-t1x9gknd 11492 28 waste waste NN cord-010119-t1x9gknd 11492 29 . . . cord-010119-t1x9gknd 11493 1 The the DT cord-010119-t1x9gknd 11493 2 objectives objective NNS cord-010119-t1x9gknd 11493 3 of of IN cord-010119-t1x9gknd 11493 4 this this DT cord-010119-t1x9gknd 11493 5 assessment assessment NN cord-010119-t1x9gknd 11493 6 were be VBD cord-010119-t1x9gknd 11493 7 to to TO cord-010119-t1x9gknd 11493 8 decipher decipher VB cord-010119-t1x9gknd 11493 9 if if IN cord-010119-t1x9gknd 11493 10 the the DT cord-010119-t1x9gknd 11493 11 platelet platelet NN cord-010119-t1x9gknd 11493 12 inventory inventory NN cord-010119-t1x9gknd 11493 13 management management NN cord-010119-t1x9gknd 11493 14 tool tool NN cord-010119-t1x9gknd 11493 15 has have VBZ cord-010119-t1x9gknd 11493 16 reduced reduce VBN cord-010119-t1x9gknd 11493 17 the the DT cord-010119-t1x9gknd 11493 18 amount amount NN cord-010119-t1x9gknd 11493 19 of of IN cord-010119-t1x9gknd 11493 20 outdated outdated JJ cord-010119-t1x9gknd 11493 21 platelet platelet NN cord-010119-t1x9gknd 11493 22 products product NNS cord-010119-t1x9gknd 11493 23 , , , cord-010119-t1x9gknd 11493 24 total total JJ cord-010119-t1x9gknd 11493 25 cost cost NN cord-010119-t1x9gknd 11493 26 of of IN cord-010119-t1x9gknd 11493 27 platelet platelet NN cord-010119-t1x9gknd 11493 28 production production NN cord-010119-t1x9gknd 11493 29 , , , cord-010119-t1x9gknd 11493 30 and and CC cord-010119-t1x9gknd 11493 31 full full JJ cord-010119-t1x9gknd 11493 32 time time NN cord-010119-t1x9gknd 11493 33 equivalent equivalent JJ cord-010119-t1x9gknd 11493 34 ( ( -LRB- cord-010119-t1x9gknd 11493 35 FTE FTE NNP cord-010119-t1x9gknd 11493 36 ) ) -RRB- cord-010119-t1x9gknd 11493 37 allocation allocation NN cord-010119-t1x9gknd 11493 38 . . . cord-010119-t1x9gknd 11494 1 Study Study NNP cord-010119-t1x9gknd 11494 2 Design Design NNP cord-010119-t1x9gknd 11494 3 / / SYM cord-010119-t1x9gknd 11494 4 Method method NN cord-010119-t1x9gknd 11494 5 : : : cord-010119-t1x9gknd 11494 6 In in IN cord-010119-t1x9gknd 11494 7 January January NNP cord-010119-t1x9gknd 11494 8 2015 2015 CD cord-010119-t1x9gknd 11494 9 , , , cord-010119-t1x9gknd 11494 10 a a DT cord-010119-t1x9gknd 11494 11 platelet platelet NN cord-010119-t1x9gknd 11494 12 inventory inventory NN cord-010119-t1x9gknd 11494 13 management management NN cord-010119-t1x9gknd 11494 14 process process NN cord-010119-t1x9gknd 11494 15 was be VBD cord-010119-t1x9gknd 11494 16 implemented implement VBN cord-010119-t1x9gknd 11494 17 which which WDT cord-010119-t1x9gknd 11494 18 uses use VBZ cord-010119-t1x9gknd 11494 19 a a DT cord-010119-t1x9gknd 11494 20 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11494 21 based base VBN cord-010119-t1x9gknd 11494 22 tool tool NN cord-010119-t1x9gknd 11494 23 to to TO cord-010119-t1x9gknd 11494 24 predict predict VB cord-010119-t1x9gknd 11494 25 the the DT cord-010119-t1x9gknd 11494 26 amount amount NN cord-010119-t1x9gknd 11494 27 of of IN cord-010119-t1x9gknd 11494 28 platelet platelet NN cord-010119-t1x9gknd 11494 29 collection collection NN cord-010119-t1x9gknd 11494 30 procedures procedure NNS cord-010119-t1x9gknd 11494 31 needed need VBN cord-010119-t1x9gknd 11494 32 to to TO cord-010119-t1x9gknd 11494 33 be be VB cord-010119-t1x9gknd 11494 34 scheduled schedule VBN cord-010119-t1x9gknd 11494 35 each each DT cord-010119-t1x9gknd 11494 36 day day NN cord-010119-t1x9gknd 11494 37 . . . cord-010119-t1x9gknd 11495 1 The the DT cord-010119-t1x9gknd 11495 2 tool tool NN cord-010119-t1x9gknd 11495 3 uses use VBZ cord-010119-t1x9gknd 11495 4 daily daily JJ cord-010119-t1x9gknd 11495 5 historical historical JJ cord-010119-t1x9gknd 11495 6 transfusion transfusion NN cord-010119-t1x9gknd 11495 7 data datum NNS cord-010119-t1x9gknd 11495 8 from from IN cord-010119-t1x9gknd 11495 9 the the DT cord-010119-t1x9gknd 11495 10 last last JJ cord-010119-t1x9gknd 11495 11 five five CD cord-010119-t1x9gknd 11495 12 weeks week NNS cord-010119-t1x9gknd 11495 13 . . . cord-010119-t1x9gknd 11496 1 Additional additional JJ cord-010119-t1x9gknd 11496 2 calculations calculation NNS cord-010119-t1x9gknd 11496 3 are be VBP cord-010119-t1x9gknd 11496 4 included include VBN cord-010119-t1x9gknd 11496 5 to to TO cord-010119-t1x9gknd 11496 6 account account VB cord-010119-t1x9gknd 11496 7 for for IN cord-010119-t1x9gknd 11496 8 deferrals deferral NNS cord-010119-t1x9gknd 11496 9 , , , cord-010119-t1x9gknd 11496 10 no no DT cord-010119-t1x9gknd 11496 11 shows show NNS cord-010119-t1x9gknd 11496 12 , , , cord-010119-t1x9gknd 11496 13 incomplete incomplete JJ cord-010119-t1x9gknd 11496 14 collections collection NNS cord-010119-t1x9gknd 11496 15 , , , cord-010119-t1x9gknd 11496 16 and and CC cord-010119-t1x9gknd 11496 17 product product NN cord-010119-t1x9gknd 11496 18 split split NN cord-010119-t1x9gknd 11496 19 rate rate NN cord-010119-t1x9gknd 11496 20 . . . cord-010119-t1x9gknd 11497 1 The the DT cord-010119-t1x9gknd 11497 2 number number NN cord-010119-t1x9gknd 11497 3 generated generate VBN cord-010119-t1x9gknd 11497 4 from from IN cord-010119-t1x9gknd 11497 5 the the DT cord-010119-t1x9gknd 11497 6 calculations calculation NNS cord-010119-t1x9gknd 11497 7 correlates correlate VBZ cord-010119-t1x9gknd 11497 8 to to IN cord-010119-t1x9gknd 11497 9 how how WRB cord-010119-t1x9gknd 11497 10 many many JJ cord-010119-t1x9gknd 11497 11 platelet platelet NN cord-010119-t1x9gknd 11497 12 collection collection NN cord-010119-t1x9gknd 11497 13 procedures procedure NNS cord-010119-t1x9gknd 11497 14 to to TO cord-010119-t1x9gknd 11497 15 schedule schedule VB cord-010119-t1x9gknd 11497 16 for for IN cord-010119-t1x9gknd 11497 17 the the DT cord-010119-t1x9gknd 11497 18 specific specific JJ cord-010119-t1x9gknd 11497 19 day day NN cord-010119-t1x9gknd 11497 20 of of IN cord-010119-t1x9gknd 11497 21 the the DT cord-010119-t1x9gknd 11497 22 week week NN cord-010119-t1x9gknd 11497 23 considering consider VBG cord-010119-t1x9gknd 11497 24 testing test VBG cord-010119-t1x9gknd 11497 25 release release NN cord-010119-t1x9gknd 11497 26 and and CC cord-010119-t1x9gknd 11497 27 historical historical JJ cord-010119-t1x9gknd 11497 28 daily daily JJ cord-010119-t1x9gknd 11497 29 transfusion transfusion NN cord-010119-t1x9gknd 11497 30 trends trend NNS cord-010119-t1x9gknd 11497 31 . . . cord-010119-t1x9gknd 11498 1 The the DT cord-010119-t1x9gknd 11498 2 effectiveness effectiveness NN cord-010119-t1x9gknd 11498 3 of of IN cord-010119-t1x9gknd 11498 4 the the DT cord-010119-t1x9gknd 11498 5 tool tool NN cord-010119-t1x9gknd 11498 6 was be VBD cord-010119-t1x9gknd 11498 7 verified verify VBN cord-010119-t1x9gknd 11498 8 by by IN cord-010119-t1x9gknd 11498 9 comparing compare VBG cord-010119-t1x9gknd 11498 10 platelet platelet NN cord-010119-t1x9gknd 11498 11 collections collection NNS cord-010119-t1x9gknd 11498 12 , , , cord-010119-t1x9gknd 11498 13 platelet platelet NN cord-010119-t1x9gknd 11498 14 products product NNS cord-010119-t1x9gknd 11498 15 outdated outdate VBN cord-010119-t1x9gknd 11498 16 , , , cord-010119-t1x9gknd 11498 17 and and CC cord-010119-t1x9gknd 11498 18 FTE FTE NNP cord-010119-t1x9gknd 11498 19 information information NN cord-010119-t1x9gknd 11498 20 for for IN cord-010119-t1x9gknd 11498 21 a a DT cord-010119-t1x9gknd 11498 22 one one CD cord-010119-t1x9gknd 11498 23 year year NN cord-010119-t1x9gknd 11498 24 period period NN cord-010119-t1x9gknd 11498 25 prior prior RB cord-010119-t1x9gknd 11498 26 to to IN cord-010119-t1x9gknd 11498 27 the the DT cord-010119-t1x9gknd 11498 28 implementation implementation NN cord-010119-t1x9gknd 11498 29 of of IN cord-010119-t1x9gknd 11498 30 platelet platelet NN cord-010119-t1x9gknd 11498 31 inventory inventory NN cord-010119-t1x9gknd 11498 32 management management NN cord-010119-t1x9gknd 11498 33 to to IN cord-010119-t1x9gknd 11498 34 one one CD cord-010119-t1x9gknd 11498 35 year year NN cord-010119-t1x9gknd 11498 36 period period NN cord-010119-t1x9gknd 11498 37 following follow VBG cord-010119-t1x9gknd 11498 38 implementation implementation NN cord-010119-t1x9gknd 11498 39 . . . cord-010119-t1x9gknd 11499 1 Results result NNS cord-010119-t1x9gknd 11500 1 /Finding /finde VBG cord-010119-t1x9gknd 11500 2 : : : cord-010119-t1x9gknd 11500 3 By by IN cord-010119-t1x9gknd 11500 4 implementing implement VBG cord-010119-t1x9gknd 11500 5 a a DT cord-010119-t1x9gknd 11500 6 platelet platelet NN cord-010119-t1x9gknd 11500 7 inventory inventory NN cord-010119-t1x9gknd 11500 8 management management NN cord-010119-t1x9gknd 11500 9 tool tool NN cord-010119-t1x9gknd 11500 10 , , , cord-010119-t1x9gknd 11500 11 collections collection NNS cord-010119-t1x9gknd 11500 12 have have VBP cord-010119-t1x9gknd 11500 13 been be VBN cord-010119-t1x9gknd 11500 14 lowered lower VBN cord-010119-t1x9gknd 11500 15 or or CC cord-010119-t1x9gknd 11500 16 shifted shift VBN cord-010119-t1x9gknd 11500 17 to to TO cord-010119-t1x9gknd 11500 18 accommodate accommodate VB cord-010119-t1x9gknd 11500 19 the the DT cord-010119-t1x9gknd 11500 20 transfusion transfusion NN cord-010119-t1x9gknd 11500 21 needs need NNS cord-010119-t1x9gknd 11500 22 . . . cord-010119-t1x9gknd 11501 1 The the DT cord-010119-t1x9gknd 11501 2 staffing staffing NN cord-010119-t1x9gknd 11501 3 adjustments adjustment NNS cord-010119-t1x9gknd 11501 4 and and CC cord-010119-t1x9gknd 11501 5 targeted target VBN cord-010119-t1x9gknd 11501 6 collections collection NNS cord-010119-t1x9gknd 11501 7 have have VBP cord-010119-t1x9gknd 11501 8 lowered lower VBN cord-010119-t1x9gknd 11501 9 FTE FTE NNP cord-010119-t1x9gknd 11501 10 and and CC cord-010119-t1x9gknd 11501 11 outdate outdate JJ cord-010119-t1x9gknd 11501 12 cost cost VBN cord-010119-t1x9gknd 11501 13 by by IN cord-010119-t1x9gknd 11501 14 22 22 CD cord-010119-t1x9gknd 11501 15 % % NN cord-010119-t1x9gknd 11501 16 . . . cord-010119-t1x9gknd 11502 1 The the DT cord-010119-t1x9gknd 11502 2 platelet platelet NN cord-010119-t1x9gknd 11502 3 outdate outdate JJ cord-010119-t1x9gknd 11502 4 rates rate NNS cord-010119-t1x9gknd 11502 5 dropped drop VBD cord-010119-t1x9gknd 11502 6 after after IN cord-010119-t1x9gknd 11502 7 implementing implement VBG cord-010119-t1x9gknd 11502 8 the the DT cord-010119-t1x9gknd 11502 9 platelet platelet NN cord-010119-t1x9gknd 11502 10 inventory inventory NN cord-010119-t1x9gknd 11502 11 tool tool NN cord-010119-t1x9gknd 11502 12 from from IN cord-010119-t1x9gknd 11502 13 14 14 CD cord-010119-t1x9gknd 11502 14 % % NN cord-010119-t1x9gknd 11502 15 ( ( -LRB- cord-010119-t1x9gknd 11502 16 1324 1324 CD cord-010119-t1x9gknd 11502 17 units unit NNS cord-010119-t1x9gknd 11502 18 ) ) -RRB- cord-010119-t1x9gknd 11502 19 to to IN cord-010119-t1x9gknd 11502 20 11 11 CD cord-010119-t1x9gknd 11502 21 % % NN cord-010119-t1x9gknd 11502 22 ( ( -LRB- cord-010119-t1x9gknd 11502 23 874 874 CD cord-010119-t1x9gknd 11502 24 units unit NNS cord-010119-t1x9gknd 11502 25 ) ) -RRB- cord-010119-t1x9gknd 11502 26 ; ; : cord-010119-t1x9gknd 11502 27 a a DT cord-010119-t1x9gknd 11502 28 21 21 CD cord-010119-t1x9gknd 11502 29 % % NN cord-010119-t1x9gknd 11502 30 decrease decrease NN cord-010119-t1x9gknd 11502 31 . . . cord-010119-t1x9gknd 11503 1 FTE FTE NNP cord-010119-t1x9gknd 11503 2 was be VBD cord-010119-t1x9gknd 11503 3 able able JJ cord-010119-t1x9gknd 11503 4 to to TO cord-010119-t1x9gknd 11503 5 be be VB cord-010119-t1x9gknd 11503 6 monitored monitor VBN cord-010119-t1x9gknd 11503 7 closely closely RB cord-010119-t1x9gknd 11503 8 with with IN cord-010119-t1x9gknd 11503 9 the the DT cord-010119-t1x9gknd 11503 10 donor donor NN cord-010119-t1x9gknd 11503 11 schedule schedule NN cord-010119-t1x9gknd 11503 12 and and CC cord-010119-t1x9gknd 11503 13 lowered lower VBD cord-010119-t1x9gknd 11503 14 from from IN cord-010119-t1x9gknd 11503 15 a a DT cord-010119-t1x9gknd 11503 16 yearly yearly JJ cord-010119-t1x9gknd 11503 17 average average NN cord-010119-t1x9gknd 11503 18 of of IN cord-010119-t1x9gknd 11503 19 7 7 CD cord-010119-t1x9gknd 11503 20 FTE FTE NNP cord-010119-t1x9gknd 11503 21 to to IN cord-010119-t1x9gknd 11503 22 6.2 6.2 CD cord-010119-t1x9gknd 11503 23 FTE fte NN cord-010119-t1x9gknd 11503 24 , , , cord-010119-t1x9gknd 11503 25 lowering lower VBG cord-010119-t1x9gknd 11503 26 FTE FTE NNP cord-010119-t1x9gknd 11503 27 by by IN cord-010119-t1x9gknd 11503 28 11 11 CD cord-010119-t1x9gknd 11503 29 % % NN cord-010119-t1x9gknd 11503 30 . . . cord-010119-t1x9gknd 11504 1 Conclusion conclusion NN cord-010119-t1x9gknd 11504 2 : : : cord-010119-t1x9gknd 11505 1 Considering consider VBG cord-010119-t1x9gknd 11505 2 historical historical JJ cord-010119-t1x9gknd 11505 3 transfusion transfusion NN cord-010119-t1x9gknd 11505 4 data datum NNS cord-010119-t1x9gknd 11505 5 for for IN cord-010119-t1x9gknd 11505 6 potential potential JJ cord-010119-t1x9gknd 11505 7 platelet platelet NN cord-010119-t1x9gknd 11505 8 demand demand NN cord-010119-t1x9gknd 11505 9 has have VBZ cord-010119-t1x9gknd 11505 10 had have VBN cord-010119-t1x9gknd 11505 11 a a DT cord-010119-t1x9gknd 11505 12 positive positive JJ cord-010119-t1x9gknd 11505 13 impact impact NN cord-010119-t1x9gknd 11505 14 on on IN cord-010119-t1x9gknd 11505 15 scheduling schedule VBG cord-010119-t1x9gknd 11505 16 platelet platelet NN cord-010119-t1x9gknd 11505 17 collections collection NNS cord-010119-t1x9gknd 11505 18 . . . cord-010119-t1x9gknd 11506 1 Staffing staffing NN cord-010119-t1x9gknd 11506 2 requirements requirement NNS cord-010119-t1x9gknd 11506 3 and and CC cord-010119-t1x9gknd 11506 4 outdating outdate VBG cord-010119-t1x9gknd 11506 5 products product NNS cord-010119-t1x9gknd 11506 6 have have VBP cord-010119-t1x9gknd 11506 7 decreased decrease VBN cord-010119-t1x9gknd 11506 8 since since IN cord-010119-t1x9gknd 11506 9 implementation implementation NN cord-010119-t1x9gknd 11506 10 of of IN cord-010119-t1x9gknd 11506 11 the the DT cord-010119-t1x9gknd 11506 12 platelet platelet NN cord-010119-t1x9gknd 11506 13 management management NN cord-010119-t1x9gknd 11506 14 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11506 15 tool tool NN cord-010119-t1x9gknd 11506 16 , , , cord-010119-t1x9gknd 11506 17 leading lead VBG cord-010119-t1x9gknd 11506 18 to to IN cord-010119-t1x9gknd 11506 19 less less JJR cord-010119-t1x9gknd 11506 20 waste waste NN cord-010119-t1x9gknd 11506 21 both both CC cord-010119-t1x9gknd 11506 22 in in IN cord-010119-t1x9gknd 11506 23 terms term NNS cord-010119-t1x9gknd 11506 24 of of IN cord-010119-t1x9gknd 11506 25 staffing staffing NN cord-010119-t1x9gknd 11506 26 and and CC cord-010119-t1x9gknd 11506 27 platelets platelet NNS cord-010119-t1x9gknd 11506 28 . . . cord-010119-t1x9gknd 11507 1 Given give VBN cord-010119-t1x9gknd 11507 2 these these DT cord-010119-t1x9gknd 11507 3 positive positive JJ cord-010119-t1x9gknd 11507 4 results result NNS cord-010119-t1x9gknd 11507 5 , , , cord-010119-t1x9gknd 11507 6 we -PRON- PRP cord-010119-t1x9gknd 11507 7 are be VBP cord-010119-t1x9gknd 11507 8 beginning begin VBG cord-010119-t1x9gknd 11507 9 to to TO cord-010119-t1x9gknd 11507 10 develop develop VB cord-010119-t1x9gknd 11507 11 a a DT cord-010119-t1x9gknd 11507 12 similar similar JJ cord-010119-t1x9gknd 11507 13 tool tool NN cord-010119-t1x9gknd 11507 14 for for IN cord-010119-t1x9gknd 11507 15 our -PRON- PRP$ cord-010119-t1x9gknd 11507 16 whole whole JJ cord-010119-t1x9gknd 11507 17 blood blood NN cord-010119-t1x9gknd 11507 18 collections collection NNS cord-010119-t1x9gknd 11507 19 . . . cord-010119-t1x9gknd 11508 1 Identifying identify VBG cord-010119-t1x9gknd 11508 2 Opportunities opportunity NNS cord-010119-t1x9gknd 11508 3 to to IN cord-010119-t1x9gknd 11508 4 Right right JJ cord-010119-t1x9gknd 11508 5 - - HYPH cord-010119-t1x9gknd 11508 6 Size size NN cord-010119-t1x9gknd 11508 7 Hospital Hospital NNP cord-010119-t1x9gknd 11508 8 Inventory inventory NN cord-010119-t1x9gknd 11508 9 Using use VBG cord-010119-t1x9gknd 11508 10 Compotrace Compotrace NNP cord-010119-t1x9gknd 11508 11 Radio Radio NNP cord-010119-t1x9gknd 11508 12 Frequency Frequency NNP cord-010119-t1x9gknd 11508 13 ID ID NNP cord-010119-t1x9gknd 11508 14 Inventory Inventory NNP cord-010119-t1x9gknd 11508 15 Management Management NNP cord-010119-t1x9gknd 11508 16 System System NNP cord-010119-t1x9gknd 11508 17 Nanci Nanci NNP cord-010119-t1x9gknd 11508 18 Fredrich Fredrich NNP cord-010119-t1x9gknd 11509 1 * * NFP cord-010119-t1x9gknd 11509 2 1 1 CD cord-010119-t1x9gknd 11509 3 , , , cord-010119-t1x9gknd 11509 4 Jaclyn Jaclyn NNP cord-010119-t1x9gknd 11509 5 McKay McKay NNP cord-010119-t1x9gknd 11509 6 1 1 CD cord-010119-t1x9gknd 11509 7 , , , cord-010119-t1x9gknd 11509 8 Jennifer Jennifer NNP cord-010119-t1x9gknd 11509 9 Curnes Curnes NNP cord-010119-t1x9gknd 11509 10 1 1 CD cord-010119-t1x9gknd 11509 11 and and CC cord-010119-t1x9gknd 11509 12 Rowena Rowena NNP cord-010119-t1x9gknd 11509 13 Punzalan Punzalan NNP cord-010119-t1x9gknd 11509 14 1,2 1,2 CD cord-010119-t1x9gknd 11509 15 . . . cord-010119-t1x9gknd 11510 1 1 1 CD cord-010119-t1x9gknd 11510 2 BloodCenter BloodCenter NNP cord-010119-t1x9gknd 11510 3 of of IN cord-010119-t1x9gknd 11510 4 Wisconsin Wisconsin NNP cord-010119-t1x9gknd 11510 5 , , , cord-010119-t1x9gknd 11510 6 2 2 CD cord-010119-t1x9gknd 11510 7 Children Children NNPS cord-010119-t1x9gknd 11510 8 's 's POS cord-010119-t1x9gknd 11510 9 Hospital Hospital NNP cord-010119-t1x9gknd 11510 10 of of IN cord-010119-t1x9gknd 11510 11 Wisconsin Wisconsin NNP cord-010119-t1x9gknd 11510 12 Background Background NNP cord-010119-t1x9gknd 11510 13 / / SYM cord-010119-t1x9gknd 11510 14 Case Case NNP cord-010119-t1x9gknd 11510 15 Studies Studies NNPS cord-010119-t1x9gknd 11510 16 : : : cord-010119-t1x9gknd 11510 17 The the DT cord-010119-t1x9gknd 11510 18 ability ability NN cord-010119-t1x9gknd 11510 19 to to TO cord-010119-t1x9gknd 11510 20 track track VB cord-010119-t1x9gknd 11510 21 inventory inventory NN cord-010119-t1x9gknd 11510 22 of of IN cord-010119-t1x9gknd 11510 23 blood blood NN cord-010119-t1x9gknd 11510 24 components component NNS cord-010119-t1x9gknd 11510 25 in in IN cord-010119-t1x9gknd 11510 26 real real JJ cord-010119-t1x9gknd 11510 27 time time NN cord-010119-t1x9gknd 11510 28 is be VBZ cord-010119-t1x9gknd 11510 29 challenging challenging JJ cord-010119-t1x9gknd 11510 30 for for IN cord-010119-t1x9gknd 11510 31 both both DT cord-010119-t1x9gknd 11510 32 hospital hospital NN cord-010119-t1x9gknd 11510 33 transfusion transfusion NN cord-010119-t1x9gknd 11510 34 services service NNS cord-010119-t1x9gknd 11510 35 ( ( -LRB- cord-010119-t1x9gknd 11510 36 TS TS NNP cord-010119-t1x9gknd 11510 37 ) ) -RRB- cord-010119-t1x9gknd 11510 38 and and CC cord-010119-t1x9gknd 11510 39 blood blood NN cord-010119-t1x9gknd 11510 40 centers center NNS cord-010119-t1x9gknd 11510 41 ( ( -LRB- cord-010119-t1x9gknd 11510 42 BC BC NNP cord-010119-t1x9gknd 11510 43 ) ) -RRB- cord-010119-t1x9gknd 11510 44 using use VBG cord-010119-t1x9gknd 11510 45 current current JJ cord-010119-t1x9gknd 11510 46 blood blood NN cord-010119-t1x9gknd 11510 47 bank bank NN cord-010119-t1x9gknd 11510 48 information information NN cord-010119-t1x9gknd 11510 49 systems system NNS cord-010119-t1x9gknd 11510 50 ( ( -LRB- cord-010119-t1x9gknd 11510 51 BBIS BBIS NNP cord-010119-t1x9gknd 11510 52 ) ) -RRB- cord-010119-t1x9gknd 11510 53 . . . cord-010119-t1x9gknd 11511 1 In in IN cord-010119-t1x9gknd 11511 2 addition addition NN cord-010119-t1x9gknd 11511 3 , , , cord-010119-t1x9gknd 11511 4 determining determine VBG cord-010119-t1x9gknd 11511 5 if if IN cord-010119-t1x9gknd 11511 6 established establish VBN cord-010119-t1x9gknd 11511 7 par par NN cord-010119-t1x9gknd 11511 8 levels level NNS cord-010119-t1x9gknd 11511 9 of of IN cord-010119-t1x9gknd 11511 10 individual individual JJ cord-010119-t1x9gknd 11511 11 components component NNS cord-010119-t1x9gknd 11511 12 meet meet VBP cord-010119-t1x9gknd 11511 13 or or CC cord-010119-t1x9gknd 11511 14 exceed exceed VBP cord-010119-t1x9gknd 11511 15 daily daily JJ cord-010119-t1x9gknd 11511 16 transfusion transfusion NN cord-010119-t1x9gknd 11511 17 needs need NNS cord-010119-t1x9gknd 11511 18 is be VBZ cord-010119-t1x9gknd 11511 19 difficult difficult JJ cord-010119-t1x9gknd 11511 20 to to TO cord-010119-t1x9gknd 11511 21 ascertain ascertain VB cord-010119-t1x9gknd 11511 22 . . . cord-010119-t1x9gknd 11512 1 A a DT cord-010119-t1x9gknd 11512 2 pilot pilot NN cord-010119-t1x9gknd 11512 3 was be VBD cord-010119-t1x9gknd 11512 4 designed design VBN cord-010119-t1x9gknd 11512 5 to to TO cord-010119-t1x9gknd 11512 6 track track VB cord-010119-t1x9gknd 11512 7 and and CC cord-010119-t1x9gknd 11512 8 monitor monitor VB cord-010119-t1x9gknd 11512 9 all all DT cord-010119-t1x9gknd 11512 10 blood blood NN cord-010119-t1x9gknd 11512 11 components component NNS cord-010119-t1x9gknd 11512 12 from from IN cord-010119-t1x9gknd 11512 13 distribution distribution NN cord-010119-t1x9gknd 11512 14 at at IN cord-010119-t1x9gknd 11512 15 the the DT cord-010119-t1x9gknd 11512 16 BC BC NNP cord-010119-t1x9gknd 11512 17 to to TO cord-010119-t1x9gknd 11512 18 issue issue VB cord-010119-t1x9gknd 11512 19 in in IN cord-010119-t1x9gknd 11512 20 a a DT cord-010119-t1x9gknd 11512 21 hospital hospital NN cord-010119-t1x9gknd 11512 22 TS ts NN cord-010119-t1x9gknd 11512 23 using use VBG cord-010119-t1x9gknd 11512 24 Fresenius Fresenius NNP cord-010119-t1x9gknd 11512 25 Kabi Kabi NNP cord-010119-t1x9gknd 11512 26 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11512 27 Radio Radio NNP cord-010119-t1x9gknd 11512 28 Frequency Frequency NNP cord-010119-t1x9gknd 11512 29 ID ID NNP cord-010119-t1x9gknd 11512 30 ( ( -LRB- cord-010119-t1x9gknd 11512 31 RFID RFID NNP cord-010119-t1x9gknd 11512 32 ) ) -RRB- cord-010119-t1x9gknd 11512 33 enabled enable VBD cord-010119-t1x9gknd 11512 34 Inventory Inventory NNP cord-010119-t1x9gknd 11512 35 Management Management NNP cord-010119-t1x9gknd 11512 36 System System NNP cord-010119-t1x9gknd 11512 37 . . . cord-010119-t1x9gknd 11513 1 The the DT cord-010119-t1x9gknd 11513 2 objectives objective NNS cord-010119-t1x9gknd 11513 3 were be VBD cord-010119-t1x9gknd 11513 4 to to TO cord-010119-t1x9gknd 11513 5 determine determine VB cord-010119-t1x9gknd 11513 6 feasibility feasibility NN cord-010119-t1x9gknd 11513 7 of of IN cord-010119-t1x9gknd 11513 8 the the DT cord-010119-t1x9gknd 11513 9 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11513 10 system system NN cord-010119-t1x9gknd 11513 11 and and CC cord-010119-t1x9gknd 11513 12 analyze analyze VB cord-010119-t1x9gknd 11513 13 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11513 14 data datum NNS cord-010119-t1x9gknd 11513 15 for for IN cord-010119-t1x9gknd 11513 16 real real JJ cord-010119-t1x9gknd 11513 17 - - HYPH cord-010119-t1x9gknd 11513 18 time time NN cord-010119-t1x9gknd 11513 19 usage usage NN cord-010119-t1x9gknd 11513 20 and and CC cord-010119-t1x9gknd 11513 21 optimal optimal JJ cord-010119-t1x9gknd 11513 22 inventory inventory NN cord-010119-t1x9gknd 11513 23 levels level NNS cord-010119-t1x9gknd 11513 24 . . . cord-010119-t1x9gknd 11514 1 Study Study NNP cord-010119-t1x9gknd 11514 2 Design Design NNP cord-010119-t1x9gknd 11514 3 / / SYM cord-010119-t1x9gknd 11514 4 Method method NN cord-010119-t1x9gknd 11514 5 : : : cord-010119-t1x9gknd 11515 1 A a DT cord-010119-t1x9gknd 11515 2 3 3 CD cord-010119-t1x9gknd 11515 3 month month NN cord-010119-t1x9gknd 11515 4 pilot pilot NN cord-010119-t1x9gknd 11515 5 was be VBD cord-010119-t1x9gknd 11515 6 conducted conduct VBN cord-010119-t1x9gknd 11515 7 at at IN cord-010119-t1x9gknd 11515 8 a a DT cord-010119-t1x9gknd 11515 9 pediatric pediatric JJ cord-010119-t1x9gknd 11515 10 hospital hospital NN cord-010119-t1x9gknd 11515 11 and and CC cord-010119-t1x9gknd 11515 12 its -PRON- PRP$ cord-010119-t1x9gknd 11515 13 BC BC NNP cord-010119-t1x9gknd 11515 14 using use VBG cord-010119-t1x9gknd 11515 15 both both CC cord-010119-t1x9gknd 11515 16 BBIS BBIS NNP cord-010119-t1x9gknd 11515 17 and and CC cord-010119-t1x9gknd 11515 18 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11515 19 systems system NNS cord-010119-t1x9gknd 11515 20 to to TO cord-010119-t1x9gknd 11515 21 track track VB cord-010119-t1x9gknd 11515 22 all all DT cord-010119-t1x9gknd 11515 23 adult adult NN cord-010119-t1x9gknd 11515 24 - - HYPH cord-010119-t1x9gknd 11515 25 size size NN cord-010119-t1x9gknd 11515 26 blood blood NN cord-010119-t1x9gknd 11515 27 components component NNS cord-010119-t1x9gknd 11515 28 . . . cord-010119-t1x9gknd 11516 1 Staff staff NN cord-010119-t1x9gknd 11516 2 were be VBD cord-010119-t1x9gknd 11516 3 trained train VBN cord-010119-t1x9gknd 11516 4 on on IN cord-010119-t1x9gknd 11516 5 use use NN cord-010119-t1x9gknd 11516 6 of of IN cord-010119-t1x9gknd 11516 7 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11516 8 system system NN cord-010119-t1x9gknd 11516 9 . . . cord-010119-t1x9gknd 11517 1 Upon upon IN cord-010119-t1x9gknd 11517 2 receipt receipt NN cord-010119-t1x9gknd 11517 3 of of IN cord-010119-t1x9gknd 11517 4 order order NN cord-010119-t1x9gknd 11517 5 from from IN cord-010119-t1x9gknd 11517 6 pilot pilot NN cord-010119-t1x9gknd 11517 7 hospital hospital NN cord-010119-t1x9gknd 11517 8 , , , cord-010119-t1x9gknd 11517 9 BC BC NNP cord-010119-t1x9gknd 11517 10 staff staff NN cord-010119-t1x9gknd 11517 11 applied apply VBD cord-010119-t1x9gknd 11517 12 RFID RFID NNP cord-010119-t1x9gknd 11517 13 tags tag NNS cord-010119-t1x9gknd 11517 14 to to IN cord-010119-t1x9gknd 11517 15 all all DT cord-010119-t1x9gknd 11517 16 component component NN cord-010119-t1x9gknd 11517 17 bags bag NNS cord-010119-t1x9gknd 11517 18 and and CC cord-010119-t1x9gknd 11517 19 scanned scan VBD cord-010119-t1x9gknd 11517 20 components component NNS cord-010119-t1x9gknd 11517 21 into into IN cord-010119-t1x9gknd 11517 22 the the DT cord-010119-t1x9gknd 11517 23 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11517 24 system system NN cord-010119-t1x9gknd 11517 25 . . . cord-010119-t1x9gknd 11518 1 Components component NNS cord-010119-t1x9gknd 11518 2 were be VBD cord-010119-t1x9gknd 11518 3 transported transport VBN cord-010119-t1x9gknd 11518 4 and and CC cord-010119-t1x9gknd 11518 5 delivered deliver VBN cord-010119-t1x9gknd 11518 6 to to IN cord-010119-t1x9gknd 11518 7 TS TS NNP cord-010119-t1x9gknd 11518 8 following follow VBG cord-010119-t1x9gknd 11518 9 established establish VBN cord-010119-t1x9gknd 11518 10 procedures procedure NNS cord-010119-t1x9gknd 11518 11 . . . cord-010119-t1x9gknd 11519 1 Upon upon IN cord-010119-t1x9gknd 11519 2 receipt receipt NN cord-010119-t1x9gknd 11519 3 at at IN cord-010119-t1x9gknd 11519 4 the the DT cord-010119-t1x9gknd 11519 5 hospital hospital NN cord-010119-t1x9gknd 11519 6 , , , cord-010119-t1x9gknd 11519 7 components component NNS cord-010119-t1x9gknd 11519 8 were be VBD cord-010119-t1x9gknd 11519 9 scanned scan VBN cord-010119-t1x9gknd 11519 10 into into IN cord-010119-t1x9gknd 11519 11 inventory inventory NN cord-010119-t1x9gknd 11519 12 using use VBG cord-010119-t1x9gknd 11519 13 both both CC cord-010119-t1x9gknd 11519 14 the the DT cord-010119-t1x9gknd 11519 15 TS TS NNP cord-010119-t1x9gknd 11519 16 BBIS BBIS NNP cord-010119-t1x9gknd 11519 17 and and CC cord-010119-t1x9gknd 11519 18 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11519 19 systems system NNS cord-010119-t1x9gknd 11519 20 . . . cord-010119-t1x9gknd 11520 1 Dual dual JJ cord-010119-t1x9gknd 11520 2 scanning scanning NN cord-010119-t1x9gknd 11520 3 of of IN cord-010119-t1x9gknd 11520 4 components component NNS cord-010119-t1x9gknd 11520 5 occurred occur VBD cord-010119-t1x9gknd 11520 6 upon upon IN cord-010119-t1x9gknd 11520 7 issue issue NN cord-010119-t1x9gknd 11520 8 to to TO cord-010119-t1x9gknd 11520 9 or or CC cord-010119-t1x9gknd 11520 10 return return VB cord-010119-t1x9gknd 11520 11 from from IN cord-010119-t1x9gknd 11520 12 floor floor NN cord-010119-t1x9gknd 11520 13 , , , cord-010119-t1x9gknd 11520 14 component component NN cord-010119-t1x9gknd 11520 15 modification modification NN cord-010119-t1x9gknd 11520 16 or or CC cord-010119-t1x9gknd 11520 17 return return NN cord-010119-t1x9gknd 11520 18 to to IN cord-010119-t1x9gknd 11520 19 BC BC NNP cord-010119-t1x9gknd 11520 20 . . . cord-010119-t1x9gknd 11521 1 Products product NNS cord-010119-t1x9gknd 11521 2 for for IN cord-010119-t1x9gknd 11521 3 emergency emergency NN cord-010119-t1x9gknd 11521 4 use use NN cord-010119-t1x9gknd 11521 5 or or CC cord-010119-t1x9gknd 11521 6 at at IN cord-010119-t1x9gknd 11521 7 time time NN cord-010119-t1x9gknd 11521 8 of of IN cord-010119-t1x9gknd 11521 9 high high JJ cord-010119-t1x9gknd 11521 10 demand demand NN cord-010119-t1x9gknd 11521 11 were be VBD cord-010119-t1x9gknd 11521 12 not not RB cord-010119-t1x9gknd 11521 13 RFID RFID NNP cord-010119-t1x9gknd 11521 14 - - HYPH cord-010119-t1x9gknd 11521 15 scanned scan VBN cord-010119-t1x9gknd 11521 16 . . . cord-010119-t1x9gknd 11522 1 A a DT cord-010119-t1x9gknd 11522 2 priori priori FW cord-010119-t1x9gknd 11522 3 , , , cord-010119-t1x9gknd 11522 4 the the DT cord-010119-t1x9gknd 11522 5 pilot pilot NN cord-010119-t1x9gknd 11522 6 would would MD cord-010119-t1x9gknd 11522 7 stop stop VB cord-010119-t1x9gknd 11522 8 if if IN cord-010119-t1x9gknd 11522 9 the the DT cord-010119-t1x9gknd 11522 10 Compo Compo NNP cord-010119-t1x9gknd 11522 11 - - HYPH cord-010119-t1x9gknd 11522 12 Trace Trace NNP cord-010119-t1x9gknd 11522 13 system system NN cord-010119-t1x9gknd 11522 14 hampered hamper VBD cord-010119-t1x9gknd 11522 15 current current JJ cord-010119-t1x9gknd 11522 16 workflow workflow NN cord-010119-t1x9gknd 11522 17 , , , cord-010119-t1x9gknd 11522 18 component component NN cord-010119-t1x9gknd 11522 19 issue issue NN cord-010119-t1x9gknd 11522 20 was be VBD cord-010119-t1x9gknd 11522 21 delayed delay VBN cord-010119-t1x9gknd 11522 22 or or CC cord-010119-t1x9gknd 11522 23 if if IN cord-010119-t1x9gknd 11522 24 TS TS NNP cord-010119-t1x9gknd 11522 25 errors error NNS cord-010119-t1x9gknd 11522 26 increased increase VBD cord-010119-t1x9gknd 11522 27 . . . cord-010119-t1x9gknd 11523 1 No no DT cord-010119-t1x9gknd 11523 2 inventory inventory NN cord-010119-t1x9gknd 11523 3 changes change NNS cord-010119-t1x9gknd 11523 4 were be VBD cord-010119-t1x9gknd 11523 5 made make VBN cord-010119-t1x9gknd 11523 6 during during IN cord-010119-t1x9gknd 11523 7 the the DT cord-010119-t1x9gknd 11523 8 pilot pilot NN cord-010119-t1x9gknd 11523 9 . . . cord-010119-t1x9gknd 11524 1 Results/ Results/ . cord-010119-t1x9gknd 11525 1 Findings finding NNS cord-010119-t1x9gknd 11525 2 : : : cord-010119-t1x9gknd 11526 1 Real real JJ cord-010119-t1x9gknd 11526 2 - - HYPH cord-010119-t1x9gknd 11526 3 time time NN cord-010119-t1x9gknd 11526 4 data datum NNS cord-010119-t1x9gknd 11526 5 from from IN cord-010119-t1x9gknd 11526 6 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11526 7 system system NN cord-010119-t1x9gknd 11526 8 provided provide VBD cord-010119-t1x9gknd 11526 9 actual actual JJ cord-010119-t1x9gknd 11526 10 usage usage NN cord-010119-t1x9gknd 11526 11 for for IN cord-010119-t1x9gknd 11526 12 all all DT cord-010119-t1x9gknd 11526 13 blood blood NN cord-010119-t1x9gknd 11526 14 components component NNS cord-010119-t1x9gknd 11526 15 including include VBG cord-010119-t1x9gknd 11526 16 component component NN cord-010119-t1x9gknd 11526 17 disposal disposal NN cord-010119-t1x9gknd 11526 18 and and CC cord-010119-t1x9gknd 11526 19 shipment shipment NN cord-010119-t1x9gknd 11526 20 to to IN cord-010119-t1x9gknd 11526 21 and and CC cord-010119-t1x9gknd 11526 22 from from IN cord-010119-t1x9gknd 11526 23 BC BC NNP cord-010119-t1x9gknd 11526 24 . . . cord-010119-t1x9gknd 11527 1 Average average JJ cord-010119-t1x9gknd 11527 2 daily daily JJ cord-010119-t1x9gknd 11527 3 RBC RBC NNP cord-010119-t1x9gknd 11527 4 inventory inventory NN cord-010119-t1x9gknd 11527 5 levels level NNS cord-010119-t1x9gknd 11527 6 and and CC cord-010119-t1x9gknd 11527 7 usage usage NN cord-010119-t1x9gknd 11527 8 for for IN cord-010119-t1x9gknd 11527 9 selected select VBN cord-010119-t1x9gknd 11527 10 blood blood NN cord-010119-t1x9gknd 11527 11 types type NNS cord-010119-t1x9gknd 11527 12 is be VBZ cord-010119-t1x9gknd 11527 13 shown show VBN cord-010119-t1x9gknd 11527 14 in in IN cord-010119-t1x9gknd 11527 15 table table NN cord-010119-t1x9gknd 11527 16 . . . cord-010119-t1x9gknd 11528 1 Lessons lesson NNS cord-010119-t1x9gknd 11528 2 learned learn VBD cord-010119-t1x9gknd 11528 3 related relate VBN cord-010119-t1x9gknd 11528 4 to to IN cord-010119-t1x9gknd 11528 5 equipment equipment NN cord-010119-t1x9gknd 11528 6 and and CC cord-010119-t1x9gknd 11528 7 workflow workflow NN cord-010119-t1x9gknd 11528 8 : : : cord-010119-t1x9gknd 11529 1 ( ( -LRB- cord-010119-t1x9gknd 11529 2 1 1 LS cord-010119-t1x9gknd 11529 3 ) ) -RRB- cord-010119-t1x9gknd 11529 4 Use use NN cord-010119-t1x9gknd 11529 5 of of IN cord-010119-t1x9gknd 11529 6 smaller small JJR cord-010119-t1x9gknd 11529 7 irradiation irradiation NN cord-010119-t1x9gknd 11529 8 canister canister NN cord-010119-t1x9gknd 11529 9 may may MD cord-010119-t1x9gknd 11529 10 damage damage VB cord-010119-t1x9gknd 11529 11 RFID RFID NNP cord-010119-t1x9gknd 11529 12 tag tag NN cord-010119-t1x9gknd 11529 13 , , , cord-010119-t1x9gknd 11529 14 which which WDT cord-010119-t1x9gknd 11529 15 was be VBD cord-010119-t1x9gknd 11529 16 resolved resolve VBN cord-010119-t1x9gknd 11529 17 by by IN cord-010119-t1x9gknd 11529 18 relocating relocate VBG cord-010119-t1x9gknd 11529 19 tag tag NN cord-010119-t1x9gknd 11529 20 , , , cord-010119-t1x9gknd 11530 1 ( ( -LRB- cord-010119-t1x9gknd 11530 2 2 2 LS cord-010119-t1x9gknd 11530 3 ) ) -RRB- cord-010119-t1x9gknd 11530 4 TS ts NN cord-010119-t1x9gknd 11530 5 workflow workflow NN cord-010119-t1x9gknd 11530 6 and and CC cord-010119-t1x9gknd 11530 7 STAT stat NN cord-010119-t1x9gknd 11530 8 orders order NNS cord-010119-t1x9gknd 11530 9 challenged challenge VBD cord-010119-t1x9gknd 11530 10 consistent consistent JJ cord-010119-t1x9gknd 11530 11 use use NN cord-010119-t1x9gknd 11530 12 of of IN cord-010119-t1x9gknd 11530 13 dual dual JJ cord-010119-t1x9gknd 11530 14 processes process NNS cord-010119-t1x9gknd 11530 15 to to TO cord-010119-t1x9gknd 11530 16 track track VB cord-010119-t1x9gknd 11530 17 component component NN cord-010119-t1x9gknd 11530 18 status status NN cord-010119-t1x9gknd 11530 19 . . . cord-010119-t1x9gknd 11531 1 However however RB cord-010119-t1x9gknd 11531 2 no no DT cord-010119-t1x9gknd 11531 3 increase increase NN cord-010119-t1x9gknd 11531 4 in in IN cord-010119-t1x9gknd 11531 5 TS TS NNP cord-010119-t1x9gknd 11531 6 errors error NNS cord-010119-t1x9gknd 11531 7 or or CC cord-010119-t1x9gknd 11531 8 delay delay NN cord-010119-t1x9gknd 11531 9 in in IN cord-010119-t1x9gknd 11531 10 issue issue NN cord-010119-t1x9gknd 11531 11 of of IN cord-010119-t1x9gknd 11531 12 components component NNS cord-010119-t1x9gknd 11531 13 occurred occur VBD cord-010119-t1x9gknd 11531 14 . . . cord-010119-t1x9gknd 11532 1 Conclusion conclusion NN cord-010119-t1x9gknd 11532 2 : : : cord-010119-t1x9gknd 11532 3 Use Use NNP cord-010119-t1x9gknd 11532 4 of of IN cord-010119-t1x9gknd 11532 5 RFID RFID NNP cord-010119-t1x9gknd 11532 6 to to TO cord-010119-t1x9gknd 11532 7 track track VB cord-010119-t1x9gknd 11532 8 blood blood NN cord-010119-t1x9gknd 11532 9 components component NNS cord-010119-t1x9gknd 11532 10 from from IN cord-010119-t1x9gknd 11532 11 BC BC NNP cord-010119-t1x9gknd 11532 12 to to IN cord-010119-t1x9gknd 11532 13 final final JJ cord-010119-t1x9gknd 11532 14 disposition disposition NN cord-010119-t1x9gknd 11532 15 is be VBZ cord-010119-t1x9gknd 11532 16 feasible feasible JJ cord-010119-t1x9gknd 11532 17 . . . cord-010119-t1x9gknd 11533 1 Real real JJ cord-010119-t1x9gknd 11533 2 - - HYPH cord-010119-t1x9gknd 11533 3 time time NN cord-010119-t1x9gknd 11533 4 data datum NNS cord-010119-t1x9gknd 11533 5 from from IN cord-010119-t1x9gknd 11533 6 CompoTrace CompoTrace NNP cord-010119-t1x9gknd 11533 7 system system NN cord-010119-t1x9gknd 11533 8 identified identify VBD cord-010119-t1x9gknd 11533 9 optimal optimal JJ cord-010119-t1x9gknd 11533 10 inventory inventory NN cord-010119-t1x9gknd 11533 11 levels level NNS cord-010119-t1x9gknd 11533 12 for for IN cord-010119-t1x9gknd 11533 13 RBC RBC NNP cord-010119-t1x9gknd 11533 14 at at IN cord-010119-t1x9gknd 11533 15 the the DT cord-010119-t1x9gknd 11533 16 pilot pilot NN cord-010119-t1x9gknd 11533 17 TS ts NN cord-010119-t1x9gknd 11533 18 . . . cord-010119-t1x9gknd 11534 1 Use use NN cord-010119-t1x9gknd 11534 2 of of IN cord-010119-t1x9gknd 11534 3 real real JJ cord-010119-t1x9gknd 11534 4 - - HYPH cord-010119-t1x9gknd 11534 5 time time NN cord-010119-t1x9gknd 11534 6 RFID RFID NNP cord-010119-t1x9gknd 11534 7 to to TO cord-010119-t1x9gknd 11534 8 track track VB cord-010119-t1x9gknd 11534 9 inventory inventory NN cord-010119-t1x9gknd 11534 10 and and CC cord-010119-t1x9gknd 11534 11 adjust adjust VB cord-010119-t1x9gknd 11534 12 target target NN cord-010119-t1x9gknd 11534 13 levels level NNS cord-010119-t1x9gknd 11534 14 based base VBN cord-010119-t1x9gknd 11534 15 on on IN cord-010119-t1x9gknd 11534 16 actual actual JJ cord-010119-t1x9gknd 11534 17 daily daily JJ cord-010119-t1x9gknd 11534 18 usage usage NN cord-010119-t1x9gknd 11534 19 over over IN cord-010119-t1x9gknd 11534 20 time time NN cord-010119-t1x9gknd 11534 21 may may MD cord-010119-t1x9gknd 11534 22 reveal reveal VB cord-010119-t1x9gknd 11534 23 seasonal seasonal JJ cord-010119-t1x9gknd 11534 24 influences influence NNS cord-010119-t1x9gknd 11534 25 that that WDT cord-010119-t1x9gknd 11534 26 affect affect VBP cord-010119-t1x9gknd 11534 27 target target NN cord-010119-t1x9gknd 11534 28 inventory inventory NN cord-010119-t1x9gknd 11534 29 . . . cord-010119-t1x9gknd 11535 1 Background Background NNP cord-010119-t1x9gknd 11535 2 / / SYM cord-010119-t1x9gknd 11535 3 Case Case NNP cord-010119-t1x9gknd 11535 4 Studies Studies NNPS cord-010119-t1x9gknd 11535 5 : : : cord-010119-t1x9gknd 11536 1 Physicians physician NNS cord-010119-t1x9gknd 11536 2 expect expect VBP cord-010119-t1x9gknd 11536 3 blood blood NN cord-010119-t1x9gknd 11536 4 to to TO cord-010119-t1x9gknd 11536 5 be be VB cord-010119-t1x9gknd 11536 6 available available JJ cord-010119-t1x9gknd 11536 7 at at IN cord-010119-t1x9gknd 11536 8 all all DT cord-010119-t1x9gknd 11536 9 times time NNS cord-010119-t1x9gknd 11536 10 . . . cord-010119-t1x9gknd 11537 1 Following follow VBG cord-010119-t1x9gknd 11537 2 a a DT cord-010119-t1x9gknd 11537 3 national national JJ cord-010119-t1x9gknd 11537 4 appeal appeal NN cord-010119-t1x9gknd 11537 5 in in IN cord-010119-t1x9gknd 11537 6 July July NNP cord-010119-t1x9gknd 11537 7 2016 2016 CD cord-010119-t1x9gknd 11537 8 for for IN cord-010119-t1x9gknd 11537 9 donors donor NNS cord-010119-t1x9gknd 11537 10 based base VBN cord-010119-t1x9gknd 11537 11 on on IN cord-010119-t1x9gknd 11537 12 a a DT cord-010119-t1x9gknd 11537 13 predicted predict VBN cord-010119-t1x9gknd 11537 14 summer summer NN cord-010119-t1x9gknd 11537 15 shortage shortage NN cord-010119-t1x9gknd 11537 16 with with IN cord-010119-t1x9gknd 11537 17 high high JJ cord-010119-t1x9gknd 11537 18 likelihood likelihood NN cord-010119-t1x9gknd 11537 19 of of IN cord-010119-t1x9gknd 11537 20 extending extend VBG cord-010119-t1x9gknd 11537 21 into into IN cord-010119-t1x9gknd 11537 22 the the DT cord-010119-t1x9gknd 11537 23 fall fall NN cord-010119-t1x9gknd 11537 24 , , , cord-010119-t1x9gknd 11537 25 our -PRON- PRP$ cord-010119-t1x9gknd 11537 26 transfusion transfusion NN cord-010119-t1x9gknd 11537 27 service service NN cord-010119-t1x9gknd 11537 28 ( ( -LRB- cord-010119-t1x9gknd 11537 29 TS TS NNP cord-010119-t1x9gknd 11537 30 ) ) -RRB- cord-010119-t1x9gknd 11537 31 recognized recognize VBD cord-010119-t1x9gknd 11537 32 a a DT cord-010119-t1x9gknd 11537 33 potentially potentially RB cord-010119-t1x9gknd 11537 34 dire dire JJ cord-010119-t1x9gknd 11537 35 situation situation NN cord-010119-t1x9gknd 11537 36 given give VBN cord-010119-t1x9gknd 11537 37 the the DT cord-010119-t1x9gknd 11537 38 institution institution NN cord-010119-t1x9gknd 11537 39 's 's POS cord-010119-t1x9gknd 11537 40 patient patient NN cord-010119-t1x9gknd 11537 41 acuity acuity NN cord-010119-t1x9gknd 11537 42 . . . cord-010119-t1x9gknd 11538 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11538 2 hospital hospital NN cord-010119-t1x9gknd 11538 3 - - HYPH cord-010119-t1x9gknd 11538 4 based base VBN cord-010119-t1x9gknd 11538 5 TS TS NNP cord-010119-t1x9gknd 11538 6 supports support VBZ cord-010119-t1x9gknd 11538 7 a a DT cord-010119-t1x9gknd 11538 8 full full JJ cord-010119-t1x9gknd 11538 9 range range NN cord-010119-t1x9gknd 11538 10 of of IN cord-010119-t1x9gknd 11538 11 services service NNS cord-010119-t1x9gknd 11538 12 : : : cord-010119-t1x9gknd 11538 13 a a DT cord-010119-t1x9gknd 11538 14 Level level NN cord-010119-t1x9gknd 11538 15 I I NNP cord-010119-t1x9gknd 11538 16 trauma trauma NN cord-010119-t1x9gknd 11538 17 service service NN cord-010119-t1x9gknd 11538 18 ; ; : cord-010119-t1x9gknd 11538 19 stem stem NN cord-010119-t1x9gknd 11538 20 cell cell NN cord-010119-t1x9gknd 11538 21 and and CC cord-010119-t1x9gknd 11538 22 solid solid JJ cord-010119-t1x9gknd 11538 23 organ organ NN cord-010119-t1x9gknd 11538 24 transplant transplant NN cord-010119-t1x9gknd 11538 25 services service NNS cord-010119-t1x9gknd 11538 26 ; ; : cord-010119-t1x9gknd 11538 27 a a DT cord-010119-t1x9gknd 11538 28 brisk brisk JJ cord-010119-t1x9gknd 11538 29 cardiothoracic cardiothoracic JJ cord-010119-t1x9gknd 11538 30 surgical surgical JJ cord-010119-t1x9gknd 11538 31 program program NN cord-010119-t1x9gknd 11538 32 ; ; : cord-010119-t1x9gknd 11538 33 a a DT cord-010119-t1x9gknd 11538 34 high high JJ cord-010119-t1x9gknd 11538 35 risk risk NN cord-010119-t1x9gknd 11538 36 obstetrical obstetrical JJ cord-010119-t1x9gknd 11538 37 service service NN cord-010119-t1x9gknd 11538 38 ; ; , cord-010119-t1x9gknd 11538 39 and and CC cord-010119-t1x9gknd 11538 40 high high JJ cord-010119-t1x9gknd 11538 41 acuity acuity NN cord-010119-t1x9gknd 11538 42 medical medical JJ cord-010119-t1x9gknd 11538 43 / / SYM cord-010119-t1x9gknd 11538 44 surgical surgical JJ cord-010119-t1x9gknd 11538 45 services service NNS cord-010119-t1x9gknd 11538 46 . . . cord-010119-t1x9gknd 11539 1 A a DT cord-010119-t1x9gknd 11539 2 regional regional JJ cord-010119-t1x9gknd 11539 3 donor donor NN cord-010119-t1x9gknd 11539 4 center center NN cord-010119-t1x9gknd 11539 5 supplies supply VBZ cord-010119-t1x9gknd 11539 6 our -PRON- PRP$ cord-010119-t1x9gknd 11539 7 blood blood NN cord-010119-t1x9gknd 11539 8 products product NNS cord-010119-t1x9gknd 11539 9 . . . cord-010119-t1x9gknd 11540 1 To to TO cord-010119-t1x9gknd 11540 2 insure insure VB cord-010119-t1x9gknd 11540 3 appropriate appropriate JJ cord-010119-t1x9gknd 11540 4 response response NN cord-010119-t1x9gknd 11540 5 to to IN cord-010119-t1x9gknd 11540 6 patient patient NN cord-010119-t1x9gknd 11540 7 needs need NNS cord-010119-t1x9gknd 11540 8 , , , cord-010119-t1x9gknd 11540 9 the the DT cord-010119-t1x9gknd 11540 10 TS TS NNP cord-010119-t1x9gknd 11540 11 created create VBD cord-010119-t1x9gknd 11540 12 a a DT cord-010119-t1x9gknd 11540 13 management management NN cord-010119-t1x9gknd 11540 14 plan plan NN cord-010119-t1x9gknd 11540 15 , , , cord-010119-t1x9gknd 11540 16 with with IN cord-010119-t1x9gknd 11540 17 input input NN cord-010119-t1x9gknd 11540 18 from from IN cord-010119-t1x9gknd 11540 19 multiple multiple JJ cord-010119-t1x9gknd 11540 20 stakeholders stakeholder NNS cord-010119-t1x9gknd 11540 21 , , , cord-010119-t1x9gknd 11540 22 to to TO cord-010119-t1x9gknd 11540 23 assist assist VB cord-010119-t1x9gknd 11540 24 with with IN cord-010119-t1x9gknd 11540 25 product product NN cord-010119-t1x9gknd 11540 26 management management NN cord-010119-t1x9gknd 11540 27 in in IN cord-010119-t1x9gknd 11540 28 times time NNS cord-010119-t1x9gknd 11540 29 of of IN cord-010119-t1x9gknd 11540 30 extreme extreme JJ cord-010119-t1x9gknd 11540 31 shortages shortage NNS cord-010119-t1x9gknd 11540 32 . . . cord-010119-t1x9gknd 11541 1 The the DT cord-010119-t1x9gknd 11541 2 approach approach NN cord-010119-t1x9gknd 11541 3 is be VBZ cord-010119-t1x9gknd 11541 4 described describe VBN cord-010119-t1x9gknd 11541 5 herein herein RB cord-010119-t1x9gknd 11541 6 . . . cord-010119-t1x9gknd 11542 1 Study Study NNP cord-010119-t1x9gknd 11542 2 Design Design NNP cord-010119-t1x9gknd 11542 3 / / SYM cord-010119-t1x9gknd 11542 4 Method method NN cord-010119-t1x9gknd 11542 5 : : : cord-010119-t1x9gknd 11542 6 At at IN cord-010119-t1x9gknd 11542 7 the the DT cord-010119-t1x9gknd 11542 8 direction direction NN cord-010119-t1x9gknd 11542 9 of of IN cord-010119-t1x9gknd 11542 10 the the DT cord-010119-t1x9gknd 11542 11 Transfusion Transfusion NNP cord-010119-t1x9gknd 11542 12 Committee Committee NNP cord-010119-t1x9gknd 11542 13 ( ( -LRB- cord-010119-t1x9gknd 11542 14 TC TC NNP cord-010119-t1x9gknd 11542 15 ) ) -RRB- cord-010119-t1x9gknd 11542 16 , , , cord-010119-t1x9gknd 11542 17 TS TS NNP cord-010119-t1x9gknd 11542 18 directors director NNS cord-010119-t1x9gknd 11542 19 presented present VBD cord-010119-t1x9gknd 11542 20 the the DT cord-010119-t1x9gknd 11542 21 concern concern NN cord-010119-t1x9gknd 11542 22 for for IN cord-010119-t1x9gknd 11542 23 impending impend VBG cord-010119-t1x9gknd 11542 24 shortages shortage NNS cord-010119-t1x9gknd 11542 25 to to IN cord-010119-t1x9gknd 11542 26 the the DT cord-010119-t1x9gknd 11542 27 hospital hospital NN cord-010119-t1x9gknd 11542 28 Quality Quality NNP cord-010119-t1x9gknd 11542 29 Directors Directors NNPS cord-010119-t1x9gknd 11542 30 ( ( -LRB- cord-010119-t1x9gknd 11542 31 QD QD NNP cord-010119-t1x9gknd 11542 32 ) ) -RRB- cord-010119-t1x9gknd 11542 33 committee committee NN cord-010119-t1x9gknd 11542 34 . . . cord-010119-t1x9gknd 11543 1 The the DT cord-010119-t1x9gknd 11543 2 QD QD NNP cord-010119-t1x9gknd 11543 3 committee committee NN cord-010119-t1x9gknd 11543 4 consists consist VBZ cord-010119-t1x9gknd 11543 5 of of IN cord-010119-t1x9gknd 11543 6 clinicians clinician NNS cord-010119-t1x9gknd 11543 7 and and CC cord-010119-t1x9gknd 11543 8 non non NNS cord-010119-t1x9gknd 11543 9 - - NNS cord-010119-t1x9gknd 11543 10 clinicians clinician NNS cord-010119-t1x9gknd 11543 11 trained train VBN cord-010119-t1x9gknd 11543 12 in in IN cord-010119-t1x9gknd 11543 13 health health NN cord-010119-t1x9gknd 11543 14 care care NN cord-010119-t1x9gknd 11543 15 quality quality NN cord-010119-t1x9gknd 11543 16 / / , cord-010119-t1x9gknd 11543 17 regulatory regulatory JJ cord-010119-t1x9gknd 11543 18 affairs affair NNS cord-010119-t1x9gknd 11543 19 who who WP cord-010119-t1x9gknd 11543 20 are be VBP cord-010119-t1x9gknd 11543 21 responsible responsible JJ cord-010119-t1x9gknd 11543 22 for for IN cord-010119-t1x9gknd 11543 23 institutional institutional JJ cord-010119-t1x9gknd 11543 24 Health Health NNP cord-010119-t1x9gknd 11543 25 Care Care NNP cord-010119-t1x9gknd 11543 26 Quality Quality NNP cord-010119-t1x9gknd 11543 27 ( ( -LRB- cord-010119-t1x9gknd 11543 28 HCQ HCQ NNP cord-010119-t1x9gknd 11543 29 ) ) -RRB- cord-010119-t1x9gknd 11543 30 activities activity NNS cord-010119-t1x9gknd 11543 31 . . . cord-010119-t1x9gknd 11544 1 The the DT cord-010119-t1x9gknd 11544 2 QD QD NNP cord-010119-t1x9gknd 11544 3 recommended recommend VBD cord-010119-t1x9gknd 11544 4 creation creation NN cord-010119-t1x9gknd 11544 5 of of IN cord-010119-t1x9gknd 11544 6 a a DT cord-010119-t1x9gknd 11544 7 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 11544 8 team team NN cord-010119-t1x9gknd 11544 9 : : : cord-010119-t1x9gknd 11544 10 " " `` cord-010119-t1x9gknd 11544 11 the the DT cord-010119-t1x9gknd 11544 12 blood blood NN cord-010119-t1x9gknd 11544 13 shortage shortage NN cord-010119-t1x9gknd 11544 14 task task NN cord-010119-t1x9gknd 11544 15 force force NN cord-010119-t1x9gknd 11544 16 ( ( -LRB- cord-010119-t1x9gknd 11544 17 BSTF BSTF NNP cord-010119-t1x9gknd 11544 18 ) ) -RRB- cord-010119-t1x9gknd 11544 19 " " '' cord-010119-t1x9gknd 11544 20 , , , cord-010119-t1x9gknd 11544 21 analogous analogous JJ cord-010119-t1x9gknd 11544 22 to to IN cord-010119-t1x9gknd 11544 23 an an DT cord-010119-t1x9gknd 11544 24 existing exist VBG cord-010119-t1x9gknd 11544 25 task task NN cord-010119-t1x9gknd 11544 26 force force NN cord-010119-t1x9gknd 11544 27 started start VBD cord-010119-t1x9gknd 11544 28 for for IN cord-010119-t1x9gknd 11544 29 management management NN cord-010119-t1x9gknd 11544 30 of of IN cord-010119-t1x9gknd 11544 31 drug drug NN cord-010119-t1x9gknd 11544 32 shortages shortage NNS cord-010119-t1x9gknd 11544 33 . . . cord-010119-t1x9gknd 11545 1 Results result NNS cord-010119-t1x9gknd 11545 2 / / SYM cord-010119-t1x9gknd 11545 3 Finding finding NN cord-010119-t1x9gknd 11545 4 : : : cord-010119-t1x9gknd 11546 1 With with IN cord-010119-t1x9gknd 11546 2 HCQ HCQ NNP cord-010119-t1x9gknd 11546 3 and and CC cord-010119-t1x9gknd 11546 4 TC TC NNP cord-010119-t1x9gknd 11546 5 support support NN cord-010119-t1x9gknd 11546 6 , , , cord-010119-t1x9gknd 11546 7 the the DT cord-010119-t1x9gknd 11546 8 TS TS NNP cord-010119-t1x9gknd 11546 9 created create VBD cord-010119-t1x9gknd 11546 10 the the DT cord-010119-t1x9gknd 11546 11 BSTF BSTF NNP cord-010119-t1x9gknd 11546 12 and and CC cord-010119-t1x9gknd 11546 13 blood blood NN cord-010119-t1x9gknd 11546 14 shortage shortage NN cord-010119-t1x9gknd 11546 15 management management NN cord-010119-t1x9gknd 11546 16 algorithm algorithm NN cord-010119-t1x9gknd 11546 17 ( ( -LRB- cord-010119-t1x9gknd 11546 18 BSMA BSMA NNP cord-010119-t1x9gknd 11546 19 ) ) -RRB- cord-010119-t1x9gknd 11546 20 . . . cord-010119-t1x9gknd 11547 1 Standing stand VBG cord-010119-t1x9gknd 11547 2 Members member NNS cord-010119-t1x9gknd 11547 3 of of IN cord-010119-t1x9gknd 11547 4 the the DT cord-010119-t1x9gknd 11547 5 BSTF BSTF NNP cord-010119-t1x9gknd 11547 6 include include VBP cord-010119-t1x9gknd 11547 7 TS TS NNP cord-010119-t1x9gknd 11547 8 Medical Medical NNP cord-010119-t1x9gknd 11547 9 Director Director NNP cord-010119-t1x9gknd 11547 10 ( ( -LRB- cord-010119-t1x9gknd 11547 11 Chair Chair NNP cord-010119-t1x9gknd 11547 12 ) ) -RRB- cord-010119-t1x9gknd 11547 13 , , , cord-010119-t1x9gknd 11547 14 Senior Senior NNP cord-010119-t1x9gknd 11547 15 Vice Vice NNP cord-010119-t1x9gknd 11547 16 President President NNP cord-010119-t1x9gknd 11547 17 ( ( -LRB- cord-010119-t1x9gknd 11547 18 SVP SVP NNP cord-010119-t1x9gknd 11547 19 ) ) -RRB- cord-010119-t1x9gknd 11547 20 of of IN cord-010119-t1x9gknd 11547 21 HCQ HCQ NNP cord-010119-t1x9gknd 11547 22 , , , cord-010119-t1x9gknd 11547 23 SVPs svp NNS cord-010119-t1x9gknd 11547 24 of of IN cord-010119-t1x9gknd 11547 25 Clinical Clinical NNP cord-010119-t1x9gknd 11547 26 Services Services NNPS cord-010119-t1x9gknd 11547 27 Director Director NNP cord-010119-t1x9gknd 11547 28 of of IN cord-010119-t1x9gknd 11547 29 Regulatory Regulatory NNP cord-010119-t1x9gknd 11547 30 Affairs Affairs NNPS cord-010119-t1x9gknd 11547 31 , , , cord-010119-t1x9gknd 11547 32 Legal Legal NNP cord-010119-t1x9gknd 11547 33 Counsel Counsel NNP cord-010119-t1x9gknd 11547 34 , , , cord-010119-t1x9gknd 11547 35 and and CC cord-010119-t1x9gknd 11547 36 representatives representative NNS cord-010119-t1x9gknd 11547 37 from from IN cord-010119-t1x9gknd 11547 38 Ethics Ethics NNP cord-010119-t1x9gknd 11547 39 , , , cord-010119-t1x9gknd 11547 40 Social Social NNP cord-010119-t1x9gknd 11547 41 Work Work NNP cord-010119-t1x9gknd 11547 42 , , , cord-010119-t1x9gknd 11547 43 Pharmacy Pharmacy NNP cord-010119-t1x9gknd 11547 44 , , , cord-010119-t1x9gknd 11547 45 Patient Patient NNP cord-010119-t1x9gknd 11547 46 Referrals Referrals NNP cord-010119-t1x9gknd 11547 47 , , , cord-010119-t1x9gknd 11547 48 and and CC cord-010119-t1x9gknd 11547 49 Communications Communications NNPS cord-010119-t1x9gknd 11547 50 . . . cord-010119-t1x9gknd 11548 1 Ad ad FW cord-010119-t1x9gknd 11548 2 hoc hoc FW cord-010119-t1x9gknd 11548 3 members member NNS cord-010119-t1x9gknd 11548 4 include include VBP cord-010119-t1x9gknd 11548 5 those those DT cord-010119-t1x9gknd 11548 6 whose whose WP$ cord-010119-t1x9gknd 11548 7 patients patient NNS cord-010119-t1x9gknd 11548 8 would would MD cord-010119-t1x9gknd 11548 9 be be VB cord-010119-t1x9gknd 11548 10 most most RBS cord-010119-t1x9gknd 11548 11 impacted impact VBN cord-010119-t1x9gknd 11548 12 by by IN cord-010119-t1x9gknd 11548 13 the the DT cord-010119-t1x9gknd 11548 14 specific specific JJ cord-010119-t1x9gknd 11548 15 shortage shortage NN cord-010119-t1x9gknd 11548 16 . . . cord-010119-t1x9gknd 11549 1 The the DT cord-010119-t1x9gknd 11549 2 BSMA BSMA NNP cord-010119-t1x9gknd 11549 3 designed design VBN cord-010119-t1x9gknd 11549 4 by by IN cord-010119-t1x9gknd 11549 5 the the DT cord-010119-t1x9gknd 11549 6 BSTF BSTF NNP cord-010119-t1x9gknd 11549 7 provides provide VBZ cord-010119-t1x9gknd 11549 8 a a DT cord-010119-t1x9gknd 11549 9 framework framework NN cord-010119-t1x9gknd 11549 10 for for IN cord-010119-t1x9gknd 11549 11 TS TS NNP cord-010119-t1x9gknd 11549 12 's 's POS cord-010119-t1x9gknd 11549 13 to to TO cord-010119-t1x9gknd 11549 14 conduct conduct VB cord-010119-t1x9gknd 11549 15 operational operational JJ cord-010119-t1x9gknd 11549 16 and and CC cord-010119-t1x9gknd 11549 17 therapeutic therapeutic JJ cord-010119-t1x9gknd 11549 18 assessments assessment NNS cord-010119-t1x9gknd 11549 19 of of IN cord-010119-t1x9gknd 11549 20 potential potential JJ cord-010119-t1x9gknd 11549 21 impact impact NN cord-010119-t1x9gknd 11549 22 and and CC cord-010119-t1x9gknd 11549 23 defines define VBZ cord-010119-t1x9gknd 11549 24 criteria criterion NNS cord-010119-t1x9gknd 11549 25 for for IN cord-010119-t1x9gknd 11549 26 convening convene VBG cord-010119-t1x9gknd 11549 27 the the DT cord-010119-t1x9gknd 11549 28 BSTF BSTF NNP cord-010119-t1x9gknd 11549 29 . . . cord-010119-t1x9gknd 11550 1 Trigger trigger NN cord-010119-t1x9gknd 11550 2 criteria criterion NNS cord-010119-t1x9gknd 11550 3 include include VBP cord-010119-t1x9gknd 11550 4 : : : cord-010119-t1x9gknd 11550 5 marked mark VBN cord-010119-t1x9gknd 11550 6 TS TS NNP cord-010119-t1x9gknd 11550 7 concern concern NN cord-010119-t1x9gknd 11550 8 ; ; , cord-010119-t1x9gknd 11550 9 essential essential JJ cord-010119-t1x9gknd 11550 10 product product NN cord-010119-t1x9gknd 11550 11 ; ; : cord-010119-t1x9gknd 11550 12 high high JJ cord-010119-t1x9gknd 11550 13 likelihood likelihood NN cord-010119-t1x9gknd 11550 14 of of IN cord-010119-t1x9gknd 11550 15 inventory inventory NN cord-010119-t1x9gknd 11550 16 depletion depletion NN cord-010119-t1x9gknd 11550 17 ; ; : cord-010119-t1x9gknd 11550 18 broad broad JJ cord-010119-t1x9gknd 11550 19 patient patient JJ cord-010119-t1x9gknd 11550 20 impact impact NN cord-010119-t1x9gknd 11550 21 . . . cord-010119-t1x9gknd 11551 1 Once once RB cord-010119-t1x9gknd 11551 2 convened convene VBN cord-010119-t1x9gknd 11551 3 , , , cord-010119-t1x9gknd 11551 4 the the DT cord-010119-t1x9gknd 11551 5 BSTF BSTF NNP cord-010119-t1x9gknd 11551 6 is be VBZ cord-010119-t1x9gknd 11551 7 responsible responsible JJ cord-010119-t1x9gknd 11551 8 for for IN cord-010119-t1x9gknd 11551 9 situational situational JJ cord-010119-t1x9gknd 11551 10 assessment assessment NN cord-010119-t1x9gknd 11551 11 and and CC cord-010119-t1x9gknd 11551 12 formulation formulation NN cord-010119-t1x9gknd 11551 13 of of IN cord-010119-t1x9gknd 11551 14 a a DT cord-010119-t1x9gknd 11551 15 management management NN cord-010119-t1x9gknd 11551 16 plan plan NN cord-010119-t1x9gknd 11551 17 , , , cord-010119-t1x9gknd 11551 18 with with IN cord-010119-t1x9gknd 11551 19 a a DT cord-010119-t1x9gknd 11551 20 goal goal NN cord-010119-t1x9gknd 11551 21 of of IN cord-010119-t1x9gknd 11551 22 maintaining maintain VBG cord-010119-t1x9gknd 11551 23 quality quality NN cord-010119-t1x9gknd 11551 24 patient patient NN cord-010119-t1x9gknd 11551 25 care care NN cord-010119-t1x9gknd 11551 26 . . . cord-010119-t1x9gknd 11552 1 Conclusion conclusion NN cord-010119-t1x9gknd 11552 2 : : : cord-010119-t1x9gknd 11553 1 Faced face VBN cord-010119-t1x9gknd 11553 2 with with IN cord-010119-t1x9gknd 11553 3 the the DT cord-010119-t1x9gknd 11553 4 potential potential NN cord-010119-t1x9gknd 11553 5 for for IN cord-010119-t1x9gknd 11553 6 limited limited JJ cord-010119-t1x9gknd 11553 7 blood blood NN cord-010119-t1x9gknd 11553 8 supply supply NN cord-010119-t1x9gknd 11553 9 , , , cord-010119-t1x9gknd 11553 10 the the DT cord-010119-t1x9gknd 11553 11 TS TS NNP cord-010119-t1x9gknd 11553 12 reached reach VBD cord-010119-t1x9gknd 11553 13 beyond beyond IN cord-010119-t1x9gknd 11553 14 the the DT cord-010119-t1x9gknd 11553 15 laboratory laboratory NN cord-010119-t1x9gknd 11553 16 and and CC cord-010119-t1x9gknd 11553 17 engaged engage VBD cord-010119-t1x9gknd 11553 18 the the DT cord-010119-t1x9gknd 11553 19 TC TC NNP cord-010119-t1x9gknd 11553 20 and and CC cord-010119-t1x9gknd 11553 21 members member NNS cord-010119-t1x9gknd 11553 22 of of IN cord-010119-t1x9gknd 11553 23 HCQ HCQ NNP cord-010119-t1x9gknd 11553 24 to to TO cord-010119-t1x9gknd 11553 25 assemble assemble VB cord-010119-t1x9gknd 11553 26 a a DT cord-010119-t1x9gknd 11553 27 robust robust JJ cord-010119-t1x9gknd 11553 28 , , , cord-010119-t1x9gknd 11553 29 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 11553 30 task task NN cord-010119-t1x9gknd 11553 31 force force NN cord-010119-t1x9gknd 11553 32 . . . cord-010119-t1x9gknd 11554 1 This this DT cord-010119-t1x9gknd 11554 2 resulted result VBD cord-010119-t1x9gknd 11554 3 in in IN cord-010119-t1x9gknd 11554 4 an an DT cord-010119-t1x9gknd 11554 5 inclusive inclusive JJ cord-010119-t1x9gknd 11554 6 plan plan NN cord-010119-t1x9gknd 11554 7 which which WDT cord-010119-t1x9gknd 11554 8 can can MD cord-010119-t1x9gknd 11554 9 be be VB cord-010119-t1x9gknd 11554 10 activated activate VBN cord-010119-t1x9gknd 11554 11 at at IN cord-010119-t1x9gknd 11554 12 any any DT cord-010119-t1x9gknd 11554 13 time time NN cord-010119-t1x9gknd 11554 14 to to TO cord-010119-t1x9gknd 11554 15 address address VB cord-010119-t1x9gknd 11554 16 shortages shortage NNS cord-010119-t1x9gknd 11554 17 , , , cord-010119-t1x9gknd 11554 18 and and CC cord-010119-t1x9gknd 11554 19 assist assist VB cord-010119-t1x9gknd 11554 20 in in IN cord-010119-t1x9gknd 11554 21 management management NN cord-010119-t1x9gknd 11554 22 of of IN cord-010119-t1x9gknd 11554 23 impacted impact VBN cord-010119-t1x9gknd 11554 24 patients patient NNS cord-010119-t1x9gknd 11554 25 . . . cord-010119-t1x9gknd 11555 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 11555 2 Background Background NNP cord-010119-t1x9gknd 11555 3 / / SYM cord-010119-t1x9gknd 11555 4 Case Case NNP cord-010119-t1x9gknd 11555 5 Studies Studies NNPS cord-010119-t1x9gknd 11555 6 : : : cord-010119-t1x9gknd 11555 7 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 11555 8 ( ( -LRB- cord-010119-t1x9gknd 11555 9 for for IN cord-010119-t1x9gknd 11555 10 short short JJ cord-010119-t1x9gknd 11555 11 " " `` cord-010119-t1x9gknd 11555 12 cryo cryo NN cord-010119-t1x9gknd 11555 13 " " '' cord-010119-t1x9gknd 11555 14 ) ) -RRB- cord-010119-t1x9gknd 11555 15 plays play VBZ cord-010119-t1x9gknd 11555 16 a a DT cord-010119-t1x9gknd 11555 17 critical critical JJ cord-010119-t1x9gknd 11555 18 role role NN cord-010119-t1x9gknd 11555 19 in in IN cord-010119-t1x9gknd 11555 20 clotting clotting NN cord-010119-t1x9gknd 11555 21 and and CC cord-010119-t1x9gknd 11555 22 controlling control VBG cord-010119-t1x9gknd 11555 23 hemorrhaging hemorrhaging NN cord-010119-t1x9gknd 11555 24 , , , cord-010119-t1x9gknd 11555 25 and and CC cord-010119-t1x9gknd 11555 26 is be VBZ cord-010119-t1x9gknd 11555 27 often often RB cord-010119-t1x9gknd 11555 28 used use VBN cord-010119-t1x9gknd 11555 29 in in IN cord-010119-t1x9gknd 11555 30 the the DT cord-010119-t1x9gknd 11555 31 treatment treatment NN cord-010119-t1x9gknd 11555 32 of of IN cord-010119-t1x9gknd 11555 33 massive massive JJ cord-010119-t1x9gknd 11555 34 trauma trauma NN cord-010119-t1x9gknd 11555 35 and and CC cord-010119-t1x9gknd 11555 36 major major JJ cord-010119-t1x9gknd 11555 37 diseases disease NNS cord-010119-t1x9gknd 11555 38 , , , cord-010119-t1x9gknd 11555 39 including include VBG cord-010119-t1x9gknd 11555 40 metastasized metastasize VBN cord-010119-t1x9gknd 11555 41 cancers cancer NNS cord-010119-t1x9gknd 11555 42 , , , cord-010119-t1x9gknd 11555 43 cardiac cardiac JJ cord-010119-t1x9gknd 11555 44 diseases disease NNS cord-010119-t1x9gknd 11555 45 , , , cord-010119-t1x9gknd 11555 46 hepatic hepatic JJ cord-010119-t1x9gknd 11555 47 failures failure NNS cord-010119-t1x9gknd 11555 48 , , , cord-010119-t1x9gknd 11555 49 and and CC cord-010119-t1x9gknd 11555 50 organ organ NN cord-010119-t1x9gknd 11555 51 transplants transplant NNS cord-010119-t1x9gknd 11555 52 . . . cord-010119-t1x9gknd 11556 1 The the DT cord-010119-t1x9gknd 11556 2 collection collection NN cord-010119-t1x9gknd 11556 3 process process NN cord-010119-t1x9gknd 11556 4 of of IN cord-010119-t1x9gknd 11556 5 cryo cryo NN cord-010119-t1x9gknd 11556 6 is be VBZ cord-010119-t1x9gknd 11556 7 particularly particularly RB cord-010119-t1x9gknd 11556 8 challenging challenging JJ cord-010119-t1x9gknd 11556 9 ; ; : cord-010119-t1x9gknd 11556 10 due due IN cord-010119-t1x9gknd 11556 11 to to IN cord-010119-t1x9gknd 11556 12 fact fact NN cord-010119-t1x9gknd 11556 13 to to TO cord-010119-t1x9gknd 11556 14 be be VB cord-010119-t1x9gknd 11556 15 processed process VBN cord-010119-t1x9gknd 11556 16 into into IN cord-010119-t1x9gknd 11556 17 cryo cryo NN cord-010119-t1x9gknd 11556 18 units unit NNS cord-010119-t1x9gknd 11556 19 , , , cord-010119-t1x9gknd 11556 20 the the DT cord-010119-t1x9gknd 11556 21 collected collect VBN cord-010119-t1x9gknd 11556 22 whole whole JJ cord-010119-t1x9gknd 11556 23 blood blood NN cord-010119-t1x9gknd 11556 24 has have VBZ cord-010119-t1x9gknd 11556 25 to to TO cord-010119-t1x9gknd 11556 26 be be VB cord-010119-t1x9gknd 11556 27 shipped ship VBN cord-010119-t1x9gknd 11556 28 to to IN cord-010119-t1x9gknd 11556 29 the the DT cord-010119-t1x9gknd 11556 30 production production NN cord-010119-t1x9gknd 11556 31 facility facility NN cord-010119-t1x9gknd 11556 32 and and CC cord-010119-t1x9gknd 11556 33 be be VB cord-010119-t1x9gknd 11556 34 processed process VBN cord-010119-t1x9gknd 11556 35 within within IN cord-010119-t1x9gknd 11556 36 8-hours 8-hours CD cord-010119-t1x9gknd 11556 37 after after IN cord-010119-t1x9gknd 11556 38 collection collection NN cord-010119-t1x9gknd 11556 39 . . . cord-010119-t1x9gknd 11557 1 This this DT cord-010119-t1x9gknd 11557 2 tight tight JJ cord-010119-t1x9gknd 11557 3 8hour 8hour CD cord-010119-t1x9gknd 11557 4 time time NN cord-010119-t1x9gknd 11557 5 constraint constraint NN cord-010119-t1x9gknd 11557 6 between between IN cord-010119-t1x9gknd 11557 7 collection collection NN cord-010119-t1x9gknd 11557 8 and and CC cord-010119-t1x9gknd 11557 9 production production NN cord-010119-t1x9gknd 11557 10 can can MD cord-010119-t1x9gknd 11557 11 only only RB cord-010119-t1x9gknd 11557 12 be be VB cord-010119-t1x9gknd 11557 13 satisfied satisfied JJ cord-010119-t1x9gknd 11557 14 with with IN cord-010119-t1x9gknd 11557 15 precision precision NN cord-010119-t1x9gknd 11557 16 collection collection NN cord-010119-t1x9gknd 11557 17 planning planning NN cord-010119-t1x9gknd 11557 18 and and CC cord-010119-t1x9gknd 11557 19 extra extra JJ cord-010119-t1x9gknd 11557 20 courier courier NN cord-010119-t1x9gknd 11557 21 services service NNS cord-010119-t1x9gknd 11557 22 ; ; : cord-010119-t1x9gknd 11557 23 which which WDT cord-010119-t1x9gknd 11557 24 makes make VBZ cord-010119-t1x9gknd 11557 25 the the DT cord-010119-t1x9gknd 11557 26 collection collection NN cord-010119-t1x9gknd 11557 27 for for IN cord-010119-t1x9gknd 11557 28 cryo cryo NN cord-010119-t1x9gknd 11557 29 units unit NNS cord-010119-t1x9gknd 11557 30 more more RBR cord-010119-t1x9gknd 11557 31 costly costly JJ cord-010119-t1x9gknd 11557 32 than than IN cord-010119-t1x9gknd 11557 33 other other JJ cord-010119-t1x9gknd 11557 34 products product NNS cord-010119-t1x9gknd 11557 35 . . . cord-010119-t1x9gknd 11558 1 Study Study NNP cord-010119-t1x9gknd 11558 2 Design Design NNP cord-010119-t1x9gknd 11558 3 / / SYM cord-010119-t1x9gknd 11558 4 Methods method NNS cord-010119-t1x9gknd 11558 5 : : : cord-010119-t1x9gknd 11559 1 The the DT cord-010119-t1x9gknd 11559 2 American American NNP cord-010119-t1x9gknd 11559 3 Red Red NNP cord-010119-t1x9gknd 11559 4 Cross Cross NNP cord-010119-t1x9gknd 11559 5 ( ( -LRB- cord-010119-t1x9gknd 11559 6 ARC ARC NNP cord-010119-t1x9gknd 11559 7 ) ) -RRB- cord-010119-t1x9gknd 11559 8 , , , cord-010119-t1x9gknd 11559 9 in in IN cord-010119-t1x9gknd 11559 10 partnership partnership NN cord-010119-t1x9gknd 11559 11 with with IN cord-010119-t1x9gknd 11559 12 researchers researcher NNS cord-010119-t1x9gknd 11559 13 from from IN cord-010119-t1x9gknd 11559 14 the the DT cord-010119-t1x9gknd 11559 15 Georgia Georgia NNP cord-010119-t1x9gknd 11559 16 Institute Institute NNP cord-010119-t1x9gknd 11559 17 of of IN cord-010119-t1x9gknd 11559 18 Technology Technology NNP cord-010119-t1x9gknd 11559 19 ( ( -LRB- cord-010119-t1x9gknd 11559 20 GT GT NNP cord-010119-t1x9gknd 11559 21 ) ) -RRB- cord-010119-t1x9gknd 11559 22 , , , cord-010119-t1x9gknd 11559 23 has have VBZ cord-010119-t1x9gknd 11559 24 developed develop VBN cord-010119-t1x9gknd 11559 25 a a DT cord-010119-t1x9gknd 11559 26 blood blood NN cord-010119-t1x9gknd 11559 27 collection collection NN cord-010119-t1x9gknd 11559 28 model model NN cord-010119-t1x9gknd 11559 29 to to TO cord-010119-t1x9gknd 11559 30 increase increase VB cord-010119-t1x9gknd 11559 31 the the DT cord-010119-t1x9gknd 11559 32 amount amount NN cord-010119-t1x9gknd 11559 33 of of IN cord-010119-t1x9gknd 11559 34 whole whole JJ cord-010119-t1x9gknd 11559 35 blood blood NN cord-010119-t1x9gknd 11559 36 that that WDT cord-010119-t1x9gknd 11559 37 can can MD cord-010119-t1x9gknd 11559 38 be be VB cord-010119-t1x9gknd 11559 39 processed process VBN cord-010119-t1x9gknd 11559 40 into into IN cord-010119-t1x9gknd 11559 41 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 11559 42 . . . cord-010119-t1x9gknd 11560 1 After after IN cord-010119-t1x9gknd 11560 2 reviewing review VBG cord-010119-t1x9gknd 11560 3 blood blood NN cord-010119-t1x9gknd 11560 4 collecting collecting NN cord-010119-t1x9gknd 11560 5 and and CC cord-010119-t1x9gknd 11560 6 processing processing NN cord-010119-t1x9gknd 11560 7 schedules schedule NNS cord-010119-t1x9gknd 11560 8 , , , cord-010119-t1x9gknd 11560 9 collection collection NN cord-010119-t1x9gknd 11560 10 locations location NNS cord-010119-t1x9gknd 11560 11 , , , cord-010119-t1x9gknd 11560 12 and and CC cord-010119-t1x9gknd 11560 13 other other JJ cord-010119-t1x9gknd 11560 14 factors factor NNS cord-010119-t1x9gknd 11560 15 , , , cord-010119-t1x9gknd 11560 16 ARC ARC NNP cord-010119-t1x9gknd 11560 17 - - HYPH cord-010119-t1x9gknd 11560 18 Cryo Cryo NNP cord-010119-t1x9gknd 11560 19 subject subject JJ cord-010119-t1x9gknd 11560 20 matter matter NN cord-010119-t1x9gknd 11560 21 experts expert NNS cord-010119-t1x9gknd 11560 22 together together RB cord-010119-t1x9gknd 11560 23 with with IN cord-010119-t1x9gknd 11560 24 GT GT NNP cord-010119-t1x9gknd 11560 25 researchers researcher NNS cord-010119-t1x9gknd 11560 26 were be VBD cord-010119-t1x9gknd 11560 27 able able JJ cord-010119-t1x9gknd 11560 28 to to TO cord-010119-t1x9gknd 11560 29 analyze analyze VB cord-010119-t1x9gknd 11560 30 the the DT cord-010119-t1x9gknd 11560 31 problem problem NN cord-010119-t1x9gknd 11560 32 structurally structurally RB cord-010119-t1x9gknd 11560 33 with with IN cord-010119-t1x9gknd 11560 34 several several JJ cord-010119-t1x9gknd 11560 35 analytic analytic JJ cord-010119-t1x9gknd 11560 36 / / SYM cord-010119-t1x9gknd 11560 37 dynamic dynamic JJ cord-010119-t1x9gknd 11560 38 programming programming NN cord-010119-t1x9gknd 11560 39 properties property NNS cord-010119-t1x9gknd 11560 40 , , , cord-010119-t1x9gknd 11560 41 and and CC cord-010119-t1x9gknd 11560 42 developed develop VBD cord-010119-t1x9gknd 11560 43 a a DT cord-010119-t1x9gknd 11560 44 near near JJ cord-010119-t1x9gknd 11560 45 optimal optimal JJ cord-010119-t1x9gknd 11560 46 solution solution NN cord-010119-t1x9gknd 11560 47 algorithm algorithm NN cord-010119-t1x9gknd 11560 48 or or CC cord-010119-t1x9gknd 11560 49 mathematical mathematical JJ cord-010119-t1x9gknd 11560 50 model model NN cord-010119-t1x9gknd 11560 51 . . . cord-010119-t1x9gknd 11561 1 Results result NNS cord-010119-t1x9gknd 11561 2 / / SYM cord-010119-t1x9gknd 11561 3 Findings finding NNS cord-010119-t1x9gknd 11561 4 : : : cord-010119-t1x9gknd 11562 1 To to TO cord-010119-t1x9gknd 11562 2 facilitate facilitate VB cord-010119-t1x9gknd 11562 3 implementation implementation NN cord-010119-t1x9gknd 11562 4 , , , cord-010119-t1x9gknd 11562 5 a a DT cord-010119-t1x9gknd 11562 6 Decision Decision NNP cord-010119-t1x9gknd 11562 7 Support Support NNP cord-010119-t1x9gknd 11562 8 Tool tool NN cord-010119-t1x9gknd 11562 9 ( ( -LRB- cord-010119-t1x9gknd 11562 10 DST DST NNP cord-010119-t1x9gknd 11562 11 ) ) -RRB- cord-010119-t1x9gknd 11562 12 was be VBD cord-010119-t1x9gknd 11562 13 developed develop VBN cord-010119-t1x9gknd 11562 14 to to TO cord-010119-t1x9gknd 11562 15 systematize systematize VB cord-010119-t1x9gknd 11562 16 the the DT cord-010119-t1x9gknd 11562 17 selection selection NN cord-010119-t1x9gknd 11562 18 of of IN cord-010119-t1x9gknd 11562 19 the the DT cord-010119-t1x9gknd 11562 20 collection collection NN cord-010119-t1x9gknd 11562 21 sites site NNS cord-010119-t1x9gknd 11562 22 ; ; , cord-010119-t1x9gknd 11562 23 determining determine VBG cord-010119-t1x9gknd 11562 24 when when WRB cord-010119-t1x9gknd 11562 25 and and CC cord-010119-t1x9gknd 11562 26 from from IN cord-010119-t1x9gknd 11562 27 which which WDT cord-010119-t1x9gknd 11562 28 mobile mobile JJ cord-010119-t1x9gknd 11562 29 collection collection NN cord-010119-t1x9gknd 11562 30 sites site NNS cord-010119-t1x9gknd 11562 31 to to TO cord-010119-t1x9gknd 11562 32 collect collect VB cord-010119-t1x9gknd 11562 33 blood blood NN cord-010119-t1x9gknd 11562 34 for for IN cord-010119-t1x9gknd 11562 35 cryo cryo NN cord-010119-t1x9gknd 11562 36 production production NN cord-010119-t1x9gknd 11562 37 and and CC cord-010119-t1x9gknd 11562 38 how how WRB cord-010119-t1x9gknd 11562 39 to to TO cord-010119-t1x9gknd 11562 40 schedule schedule VB cord-010119-t1x9gknd 11562 41 the the DT cord-010119-t1x9gknd 11562 42 courier courier NN cord-010119-t1x9gknd 11562 43 services service NNS cord-010119-t1x9gknd 11562 44 such such JJ cord-010119-t1x9gknd 11562 45 that that IN cord-010119-t1x9gknd 11562 46 the the DT cord-010119-t1x9gknd 11562 47 collection collection NN cord-010119-t1x9gknd 11562 48 targets target NNS cord-010119-t1x9gknd 11562 49 are be VBP cord-010119-t1x9gknd 11562 50 met meet VBN cord-010119-t1x9gknd 11562 51 and and CC cord-010119-t1x9gknd 11562 52 the the DT cord-010119-t1x9gknd 11562 53 total total JJ cord-010119-t1x9gknd 11562 54 collection collection NN cord-010119-t1x9gknd 11562 55 costs cost NNS cord-010119-t1x9gknd 11562 56 are be VBP cord-010119-t1x9gknd 11562 57 minimized minimize VBN cord-010119-t1x9gknd 11562 58 . . . cord-010119-t1x9gknd 11563 1 The the DT cord-010119-t1x9gknd 11563 2 implementation implementation NN cord-010119-t1x9gknd 11563 3 of of IN cord-010119-t1x9gknd 11563 4 the the DT cord-010119-t1x9gknd 11563 5 DST DST NNP cord-010119-t1x9gknd 11563 6 led lead VBD cord-010119-t1x9gknd 11563 7 to to IN cord-010119-t1x9gknd 11563 8 an an DT cord-010119-t1x9gknd 11563 9 increase increase NN cord-010119-t1x9gknd 11563 10 in in IN cord-010119-t1x9gknd 11563 11 the the DT cord-010119-t1x9gknd 11563 12 number number NN cord-010119-t1x9gknd 11563 13 of of IN cord-010119-t1x9gknd 11563 14 whole whole JJ cord-010119-t1x9gknd 11563 15 blood blood NN cord-010119-t1x9gknd 11563 16 units unit NNS cord-010119-t1x9gknd 11563 17 satisfying satisfy VBG cord-010119-t1x9gknd 11563 18 the the DT cord-010119-t1x9gknd 11563 19 tight tight JJ cord-010119-t1x9gknd 11563 20 8-hour 8-hour CD cord-010119-t1x9gknd 11563 21 completion completion NN cord-010119-t1x9gknd 11563 22 time time NN cord-010119-t1x9gknd 11563 23 constraint constraint NN cord-010119-t1x9gknd 11563 24 for for IN cord-010119-t1x9gknd 11563 25 cryo cryo NN cord-010119-t1x9gknd 11563 26 production production NN cord-010119-t1x9gknd 11563 27 ( ( -LRB- cord-010119-t1x9gknd 11563 28 capacity capacity NN cord-010119-t1x9gknd 11563 29 expansion expansion NN cord-010119-t1x9gknd 11563 30 ) ) -RRB- cord-010119-t1x9gknd 11563 31 . . . cord-010119-t1x9gknd 11564 1 In in IN cord-010119-t1x9gknd 11564 2 particular particular JJ cord-010119-t1x9gknd 11564 3 , , , cord-010119-t1x9gknd 11564 4 during during IN cord-010119-t1x9gknd 11564 5 the the DT cord-010119-t1x9gknd 11564 6 4 4 CD cord-010119-t1x9gknd 11564 7 th th XX cord-010119-t1x9gknd 11564 8 -Quarter -quarter NN cord-010119-t1x9gknd 11564 9 of of IN cord-010119-t1x9gknd 11564 10 2016 2016 CD cord-010119-t1x9gknd 11564 11 , , , cord-010119-t1x9gknd 11564 12 a a DT cord-010119-t1x9gknd 11564 13 blood blood NN cord-010119-t1x9gknd 11564 14 processing processing NN cord-010119-t1x9gknd 11564 15 region region NN cord-010119-t1x9gknd 11564 16 was be VBD cord-010119-t1x9gknd 11564 17 able able JJ cord-010119-t1x9gknd 11564 18 to to TO cord-010119-t1x9gknd 11564 19 process process VB cord-010119-t1x9gknd 11564 20 about about RB cord-010119-t1x9gknd 11564 21 1000 1000 CD cord-010119-t1x9gknd 11564 22 more more JJR cord-010119-t1x9gknd 11564 23 cryo cryo NN cord-010119-t1x9gknd 11564 24 units unit NNS cord-010119-t1x9gknd 11564 25 / / SYM cord-010119-t1x9gknd 11564 26 month month NN cord-010119-t1x9gknd 11564 27 ( ( -LRB- cord-010119-t1x9gknd 11564 28 an an DT cord-010119-t1x9gknd 11564 29 increase increase NN cord-010119-t1x9gknd 11564 30 of of IN cord-010119-t1x9gknd 11564 31 20 20 CD cord-010119-t1x9gknd 11564 32 % % NN cord-010119-t1x9gknd 11564 33 ) ) -RRB- cord-010119-t1x9gknd 11564 34 at at IN cord-010119-t1x9gknd 11564 35 a a DT cord-010119-t1x9gknd 11564 36 slightly slightly RB cord-010119-t1x9gknd 11564 37 lower low JJR cord-010119-t1x9gknd 11564 38 collection collection NN cord-010119-t1x9gknd 11564 39 cost cost NN cord-010119-t1x9gknd 11564 40 ( ( -LRB- cord-010119-t1x9gknd 11564 41 cost cost NN cord-010119-t1x9gknd 11564 42 avoidance avoidance NN cord-010119-t1x9gknd 11564 43 ) ) -RRB- cord-010119-t1x9gknd 11564 44 , , , cord-010119-t1x9gknd 11564 45 resulting result VBG cord-010119-t1x9gknd 11564 46 in in IN cord-010119-t1x9gknd 11564 47 an an DT cord-010119-t1x9gknd 11564 48 approximately approximately RB cord-010119-t1x9gknd 11564 49 40 40 CD cord-010119-t1x9gknd 11564 50 % % NN cord-010119-t1x9gknd 11564 51 reduction reduction NN cord-010119-t1x9gknd 11564 52 in in IN cord-010119-t1x9gknd 11564 53 the the DT cord-010119-t1x9gknd 11564 54 per per IN cord-010119-t1x9gknd 11564 55 unit unit NN cord-010119-t1x9gknd 11564 56 collection collection NN cord-010119-t1x9gknd 11564 57 cost cost NN cord-010119-t1x9gknd 11564 58 for for IN cord-010119-t1x9gknd 11564 59 cryo cryo NN cord-010119-t1x9gknd 11564 60 . . . cord-010119-t1x9gknd 11565 1 Conclusion conclusion NN cord-010119-t1x9gknd 11565 2 : : : cord-010119-t1x9gknd 11565 3 By by IN cord-010119-t1x9gknd 11565 4 utilizing utilize VBG cord-010119-t1x9gknd 11565 5 Operations Operations NNPS cord-010119-t1x9gknd 11565 6 Research Research NNP cord-010119-t1x9gknd 11565 7 toolkits toolkit NNS cord-010119-t1x9gknd 11565 8 , , , cord-010119-t1x9gknd 11565 9 a a DT cord-010119-t1x9gknd 11565 10 mathematical mathematical JJ cord-010119-t1x9gknd 11565 11 model model NN cord-010119-t1x9gknd 11565 12 or or CC cord-010119-t1x9gknd 11565 13 near near JJ cord-010119-t1x9gknd 11565 14 - - HYPH cord-010119-t1x9gknd 11565 15 optimal optimal NN cord-010119-t1x9gknd 11565 16 algorithm algorithm NN cord-010119-t1x9gknd 11565 17 could could MD cord-010119-t1x9gknd 11565 18 be be VB cord-010119-t1x9gknd 11565 19 developed develop VBN cord-010119-t1x9gknd 11565 20 to to TO cord-010119-t1x9gknd 11565 21 optimize optimize VB cord-010119-t1x9gknd 11565 22 the the DT cord-010119-t1x9gknd 11565 23 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 11565 24 collection collection NN cord-010119-t1x9gknd 11565 25 process process NN cord-010119-t1x9gknd 11565 26 , , , cord-010119-t1x9gknd 11565 27 ensuring ensure VBG cord-010119-t1x9gknd 11565 28 the the DT cord-010119-t1x9gknd 11565 29 time time NN cord-010119-t1x9gknd 11565 30 constraints constraint NNS cord-010119-t1x9gknd 11565 31 and and CC cord-010119-t1x9gknd 11565 32 product product NN cord-010119-t1x9gknd 11565 33 consistency consistency NN cord-010119-t1x9gknd 11565 34 levels level NNS cord-010119-t1x9gknd 11565 35 are be VBP cord-010119-t1x9gknd 11565 36 achieved achieve VBN cord-010119-t1x9gknd 11565 37 . . . cord-010119-t1x9gknd 11566 1 This this DT cord-010119-t1x9gknd 11566 2 interdisciplinary interdisciplinary JJ cord-010119-t1x9gknd 11566 3 improving improve VBG cord-010119-t1x9gknd 11566 4 cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 11566 5 collections collection NNS cord-010119-t1x9gknd 11566 6 collaborative collaborative JJ cord-010119-t1x9gknd 11566 7 project project NN cord-010119-t1x9gknd 11566 8 has have VBZ cord-010119-t1x9gknd 11566 9 been be VBN cord-010119-t1x9gknd 11566 10 selected select VBN cord-010119-t1x9gknd 11566 11 as as IN cord-010119-t1x9gknd 11566 12 a a DT cord-010119-t1x9gknd 11566 13 Finalist Finalist NNP cord-010119-t1x9gknd 11566 14 on on IN cord-010119-t1x9gknd 11566 15 the the DT cord-010119-t1x9gknd 11566 16 2017-The 2017-the CD cord-010119-t1x9gknd 11566 17 Franz Franz NNP cord-010119-t1x9gknd 11566 18 Edelman Edelman NNP cord-010119-t1x9gknd 11566 19 award award NN cord-010119-t1x9gknd 11566 20 , , , cord-010119-t1x9gknd 11566 21 recognizing recognize VBG cord-010119-t1x9gknd 11566 22 outstanding outstanding JJ cord-010119-t1x9gknd 11566 23 achievements achievement NNS cord-010119-t1x9gknd 11566 24 and and CC cord-010119-t1x9gknd 11566 25 practices practice NNS cord-010119-t1x9gknd 11566 26 in in IN cord-010119-t1x9gknd 11566 27 Operations Operations NNP cord-010119-t1x9gknd 11566 28 Research Research NNP cord-010119-t1x9gknd 11566 29 . . . cord-010119-t1x9gknd 11567 1 Inventory Inventory NNP cord-010119-t1x9gknd 11567 2 Management Management NNP cord-010119-t1x9gknd 11567 3 and and CC cord-010119-t1x9gknd 11567 4 Transfusion Transfusion NNP cord-010119-t1x9gknd 11567 5 Practice Practice NNP cord-010119-t1x9gknd 11567 6 before before IN cord-010119-t1x9gknd 11567 7 and and CC cord-010119-t1x9gknd 11567 8 after after IN cord-010119-t1x9gknd 11567 9 7-Day 7-day JJ cord-010119-t1x9gknd 11567 10 Apheresis Apheresis NNP cord-010119-t1x9gknd 11567 11 Platelets platelet NNS cord-010119-t1x9gknd 11567 12 Sarah Sarah NNP cord-010119-t1x9gknd 11567 13 K K NNP cord-010119-t1x9gknd 11567 14 Harm Harm NNP cord-010119-t1x9gknd 11567 15 * * NFP cord-010119-t1x9gknd 11567 16 . . . cord-010119-t1x9gknd 11568 1 University University NNP cord-010119-t1x9gknd 11568 2 of of IN cord-010119-t1x9gknd 11568 3 Vermont Vermont NNP cord-010119-t1x9gknd 11568 4 Medical Medical NNP cord-010119-t1x9gknd 11568 5 Center Center NNP cord-010119-t1x9gknd 11568 6 Background Background NNP cord-010119-t1x9gknd 11568 7 / / SYM cord-010119-t1x9gknd 11568 8 Case Case NNP cord-010119-t1x9gknd 11568 9 Studies Studies NNPS cord-010119-t1x9gknd 11568 10 : : : cord-010119-t1x9gknd 11569 1 The the DT cord-010119-t1x9gknd 11569 2 shelf shelf NN cord-010119-t1x9gknd 11569 3 life life NN cord-010119-t1x9gknd 11569 4 of of IN cord-010119-t1x9gknd 11569 5 apheresis apheresis NN cord-010119-t1x9gknd 11569 6 platelet platelet NN cord-010119-t1x9gknd 11569 7 ( ( -LRB- cord-010119-t1x9gknd 11569 8 AP AP NNP cord-010119-t1x9gknd 11569 9 ) ) -RRB- cord-010119-t1x9gknd 11569 10 units unit NNS cord-010119-t1x9gknd 11569 11 stored store VBN cord-010119-t1x9gknd 11569 12 in in IN cord-010119-t1x9gknd 11569 13 plasma plasma NN cord-010119-t1x9gknd 11569 14 may may MD cord-010119-t1x9gknd 11569 15 be be VB cord-010119-t1x9gknd 11569 16 extended extend VBN cord-010119-t1x9gknd 11569 17 from from IN cord-010119-t1x9gknd 11569 18 5 5 CD cord-010119-t1x9gknd 11569 19 to to TO cord-010119-t1x9gknd 11569 20 7 7 CD cord-010119-t1x9gknd 11569 21 days day NNS cord-010119-t1x9gknd 11569 22 in in IN cord-010119-t1x9gknd 11569 23 the the DT cord-010119-t1x9gknd 11569 24 USA USA NNP cord-010119-t1x9gknd 11569 25 using use VBG cord-010119-t1x9gknd 11569 26 an an DT cord-010119-t1x9gknd 11569 27 FDA FDA NNP cord-010119-t1x9gknd 11569 28 cleared clear VBN cord-010119-t1x9gknd 11569 29 rapid rapid JJ cord-010119-t1x9gknd 11569 30 test test NN cord-010119-t1x9gknd 11569 31 ( ( -LRB- cord-010119-t1x9gknd 11569 32 RT RT NNP cord-010119-t1x9gknd 11569 33 ) ) -RRB- cord-010119-t1x9gknd 11569 34 . . . cord-010119-t1x9gknd 11570 1 In in IN cord-010119-t1x9gknd 11570 2 August August NNP cord-010119-t1x9gknd 11570 3 2016 2016 CD cord-010119-t1x9gknd 11570 4 , , , cord-010119-t1x9gknd 11570 5 our -PRON- PRP$ cord-010119-t1x9gknd 11570 6 hospital hospital NN cord-010119-t1x9gknd 11570 7 based base VBN cord-010119-t1x9gknd 11570 8 transfusion transfusion NN cord-010119-t1x9gknd 11570 9 service service NN cord-010119-t1x9gknd 11570 10 began begin VBD cord-010119-t1x9gknd 11570 11 using use VBG cord-010119-t1x9gknd 11570 12 a a DT cord-010119-t1x9gknd 11570 13 RT RT NNP cord-010119-t1x9gknd 11570 14 on on IN cord-010119-t1x9gknd 11570 15 day day NN cord-010119-t1x9gknd 11570 16 6 6 CD cord-010119-t1x9gknd 11570 17 and and CC cord-010119-t1x9gknd 11570 18 7 7 CD cord-010119-t1x9gknd 11570 19 to to TO cord-010119-t1x9gknd 11570 20 routinely routinely RB cord-010119-t1x9gknd 11570 21 extend extend VB cord-010119-t1x9gknd 11570 22 AP AP NNP cord-010119-t1x9gknd 11570 23 shelf shelf NN cord-010119-t1x9gknd 11570 24 life life NN cord-010119-t1x9gknd 11570 25 to to IN cord-010119-t1x9gknd 11570 26 7 7 CD cord-010119-t1x9gknd 11570 27 days day NNS cord-010119-t1x9gknd 11570 28 . . . cord-010119-t1x9gknd 11571 1 This this DT cord-010119-t1x9gknd 11571 2 report report NN cord-010119-t1x9gknd 11571 3 describes describe VBZ cord-010119-t1x9gknd 11571 4 changes change NNS cord-010119-t1x9gknd 11571 5 in in IN cord-010119-t1x9gknd 11571 6 platelet platelet NN cord-010119-t1x9gknd 11571 7 inventory inventory NN cord-010119-t1x9gknd 11571 8 management management NN cord-010119-t1x9gknd 11571 9 and and CC cord-010119-t1x9gknd 11571 10 transfusion transfusion NN cord-010119-t1x9gknd 11571 11 practice practice NN cord-010119-t1x9gknd 11571 12 six six CD cord-010119-t1x9gknd 11571 13 months month NNS cord-010119-t1x9gknd 11571 14 following follow VBG cord-010119-t1x9gknd 11571 15 routine routine JJ cord-010119-t1x9gknd 11571 16 use use NN cord-010119-t1x9gknd 11571 17 of of IN cord-010119-t1x9gknd 11571 18 7-Day 7-day JJ cord-010119-t1x9gknd 11571 19 AP AP NNP cord-010119-t1x9gknd 11571 20 . . . cord-010119-t1x9gknd 11572 1 Study Study NNP cord-010119-t1x9gknd 11572 2 Design Design NNP cord-010119-t1x9gknd 11572 3 / / SYM cord-010119-t1x9gknd 11572 4 Methods method NNS cord-010119-t1x9gknd 11572 5 : : : cord-010119-t1x9gknd 11573 1 Data datum NNS cord-010119-t1x9gknd 11573 2 were be VBD cord-010119-t1x9gknd 11573 3 obtained obtain VBN cord-010119-t1x9gknd 11573 4 for for IN cord-010119-t1x9gknd 11573 5 two two CD cord-010119-t1x9gknd 11573 6 study study NN cord-010119-t1x9gknd 11573 7 periods period NNS cord-010119-t1x9gknd 11573 8 : : : cord-010119-t1x9gknd 11573 9 September September NNP cord-010119-t1x9gknd 11573 10 2015-February 2015-february CD cord-010119-t1x9gknd 11573 11 2016 2016 CD cord-010119-t1x9gknd 11573 12 ( ( -LRB- cord-010119-t1x9gknd 11573 13 pre pre JJ cord-010119-t1x9gknd 11573 14 - - NN cord-010119-t1x9gknd 11573 15 implementation implementation JJ cord-010119-t1x9gknd 11573 16 ) ) -RRB- cord-010119-t1x9gknd 11573 17 and and CC cord-010119-t1x9gknd 11573 18 September September NNP cord-010119-t1x9gknd 11573 19 2016-February 2016-february CD cord-010119-t1x9gknd 11573 20 2017 2017 CD cord-010119-t1x9gknd 11573 21 ( ( -LRB- cord-010119-t1x9gknd 11573 22 post post NN cord-010119-t1x9gknd 11573 23 - - NN cord-010119-t1x9gknd 11573 24 implementation implementation JJ cord-010119-t1x9gknd 11573 25 ) ) -RRB- cord-010119-t1x9gknd 11573 26 . . . cord-010119-t1x9gknd 11574 1 The the DT cord-010119-t1x9gknd 11574 2 study study NN cord-010119-t1x9gknd 11574 3 periods period NNS cord-010119-t1x9gknd 11574 4 were be VBD cord-010119-t1x9gknd 11574 5 intentionally intentionally RB cord-010119-t1x9gknd 11574 6 made make VBN cord-010119-t1x9gknd 11574 7 to to TO cord-010119-t1x9gknd 11574 8 span span VB cord-010119-t1x9gknd 11574 9 the the DT cord-010119-t1x9gknd 11574 10 same same JJ cord-010119-t1x9gknd 11574 11 months month NNS cord-010119-t1x9gknd 11574 12 of of IN cord-010119-t1x9gknd 11574 13 the the DT cord-010119-t1x9gknd 11574 14 year year NN cord-010119-t1x9gknd 11574 15 due due IN cord-010119-t1x9gknd 11574 16 to to IN cord-010119-t1x9gknd 11574 17 seasonal seasonal JJ cord-010119-t1x9gknd 11574 18 variability variability NN cord-010119-t1x9gknd 11574 19 in in IN cord-010119-t1x9gknd 11574 20 platelet platelet NN cord-010119-t1x9gknd 11574 21 transfusion transfusion NN cord-010119-t1x9gknd 11574 22 rates rate NNS cord-010119-t1x9gknd 11574 23 in in IN cord-010119-t1x9gknd 11574 24 our -PRON- PRP$ cord-010119-t1x9gknd 11574 25 region region NN cord-010119-t1x9gknd 11574 26 . . . cord-010119-t1x9gknd 11575 1 The the DT cord-010119-t1x9gknd 11575 2 transition transition NN cord-010119-t1x9gknd 11575 3 period period NN cord-010119-t1x9gknd 11575 4 from from IN cord-010119-t1x9gknd 11575 5 5-Day 5-day CD cord-010119-t1x9gknd 11575 6 to to IN cord-010119-t1x9gknd 11575 7 7-Day 7-day JJ cord-010119-t1x9gknd 11575 8 AP AP NNP cord-010119-t1x9gknd 11575 9 inventory inventory NN cord-010119-t1x9gknd 11575 10 was be VBD cord-010119-t1x9gknd 11575 11 excluded exclude VBN cord-010119-t1x9gknd 11575 12 . . . cord-010119-t1x9gknd 11576 1 The the DT cord-010119-t1x9gknd 11576 2 following follow VBG cord-010119-t1x9gknd 11576 3 data datum NNS cord-010119-t1x9gknd 11576 4 was be VBD cord-010119-t1x9gknd 11576 5 collected collect VBN cord-010119-t1x9gknd 11576 6 for for IN cord-010119-t1x9gknd 11576 7 each each DT cord-010119-t1x9gknd 11576 8 study study NN cord-010119-t1x9gknd 11576 9 period period NN cord-010119-t1x9gknd 11576 10 : : : cord-010119-t1x9gknd 11576 11 the the DT cord-010119-t1x9gknd 11576 12 total total JJ cord-010119-t1x9gknd 11576 13 number number NN cord-010119-t1x9gknd 11576 14 of of IN cord-010119-t1x9gknd 11576 15 AP AP NNP cord-010119-t1x9gknd 11576 16 transfusion transfusion NN cord-010119-t1x9gknd 11576 17 recipients recipient NNS cord-010119-t1x9gknd 11576 18 , , , cord-010119-t1x9gknd 11576 19 AP AP NNP cord-010119-t1x9gknd 11576 20 units unit NNS cord-010119-t1x9gknd 11576 21 transfused transfuse VBN cord-010119-t1x9gknd 11576 22 , , , cord-010119-t1x9gknd 11576 23 expired expire VBD cord-010119-t1x9gknd 11576 24 AP AP NNP cord-010119-t1x9gknd 11576 25 units unit NNS cord-010119-t1x9gknd 11576 26 , , , cord-010119-t1x9gknd 11576 27 AP AP NNP cord-010119-t1x9gknd 11576 28 units unit NNS cord-010119-t1x9gknd 11576 29 ordered order VBD cord-010119-t1x9gknd 11576 30 ad ad NN cord-010119-t1x9gknd 11576 31 - - HYPH cord-010119-t1x9gknd 11576 32 hoc hoc FW cord-010119-t1x9gknd 11576 33 from from IN cord-010119-t1x9gknd 11576 34 suppliers supplier NNS cord-010119-t1x9gknd 11576 35 , , , cord-010119-t1x9gknd 11576 36 inpatient inpatient JJ cord-010119-t1x9gknd 11576 37 admissions admission NNS cord-010119-t1x9gknd 11576 38 , , , cord-010119-t1x9gknd 11576 39 surgical surgical JJ cord-010119-t1x9gknd 11576 40 volumes volume NNS cord-010119-t1x9gknd 11576 41 , , , cord-010119-t1x9gknd 11576 42 and and CC cord-010119-t1x9gknd 11576 43 average average JJ cord-010119-t1x9gknd 11576 44 length length NN cord-010119-t1x9gknd 11576 45 of of IN cord-010119-t1x9gknd 11576 46 stay stay NN cord-010119-t1x9gknd 11576 47 . . . cord-010119-t1x9gknd 11577 1 Results/ Results/ . cord-010119-t1x9gknd 11578 1 Findings finding NNS cord-010119-t1x9gknd 11578 2 : : : cord-010119-t1x9gknd 11579 1 Data datum NNS cord-010119-t1x9gknd 11579 2 are be VBP cord-010119-t1x9gknd 11579 3 shown show VBN cord-010119-t1x9gknd 11579 4 in in IN cord-010119-t1x9gknd 11579 5 the the DT cord-010119-t1x9gknd 11579 6 Table table NN cord-010119-t1x9gknd 11579 7 . . . cord-010119-t1x9gknd 11580 1 The the DT cord-010119-t1x9gknd 11580 2 number number NN cord-010119-t1x9gknd 11580 3 of of IN cord-010119-t1x9gknd 11580 4 AP AP NNP cord-010119-t1x9gknd 11580 5 transfusions transfusion NNS cord-010119-t1x9gknd 11580 6 decreased decrease VBD cord-010119-t1x9gknd 11580 7 by by IN cord-010119-t1x9gknd 11580 8 3 3 CD cord-010119-t1x9gknd 11580 9 % % NN cord-010119-t1x9gknd 11580 10 post post NN cord-010119-t1x9gknd 11580 11 - - NN cord-010119-t1x9gknd 11580 12 implementation implementation JJ cord-010119-t1x9gknd 11580 13 while while IN cord-010119-t1x9gknd 11580 14 inpatient inpatient JJ cord-010119-t1x9gknd 11580 15 admissions admission NNS cord-010119-t1x9gknd 11580 16 and and CC cord-010119-t1x9gknd 11580 17 surgical surgical JJ cord-010119-t1x9gknd 11580 18 volume volume NN cord-010119-t1x9gknd 11580 19 increased increase VBN cord-010119-t1x9gknd 11580 20 by by IN cord-010119-t1x9gknd 11580 21 1 1 CD cord-010119-t1x9gknd 11580 22 % % NN cord-010119-t1x9gknd 11580 23 and and CC cord-010119-t1x9gknd 11580 24 3 3 CD cord-010119-t1x9gknd 11580 25 % % NN cord-010119-t1x9gknd 11580 26 , , , cord-010119-t1x9gknd 11580 27 respectively respectively RB cord-010119-t1x9gknd 11580 28 . . . cord-010119-t1x9gknd 11581 1 The the DT cord-010119-t1x9gknd 11581 2 hospital hospital NN cord-010119-t1x9gknd 11581 3 length length NN cord-010119-t1x9gknd 11581 4 of of IN cord-010119-t1x9gknd 11581 5 stay stay NN cord-010119-t1x9gknd 11581 6 was be VBD cord-010119-t1x9gknd 11581 7 similar similar JJ cord-010119-t1x9gknd 11581 8 for for IN cord-010119-t1x9gknd 11581 9 both both DT cord-010119-t1x9gknd 11581 10 periods period NNS cord-010119-t1x9gknd 11581 11 . . . cord-010119-t1x9gknd 11582 1 AP AP NNP cord-010119-t1x9gknd 11582 2 inventory inventory NN cord-010119-t1x9gknd 11582 3 decreased decrease VBD cord-010119-t1x9gknd 11582 4 by by IN cord-010119-t1x9gknd 11582 5 36 36 CD cord-010119-t1x9gknd 11582 6 % % NN cord-010119-t1x9gknd 11582 7 post post NN cord-010119-t1x9gknd 11582 8 - - NN cord-010119-t1x9gknd 11582 9 implementation implementation NN cord-010119-t1x9gknd 11582 10 and and CC cord-010119-t1x9gknd 11582 11 the the DT cord-010119-t1x9gknd 11582 12 outdate outdate JJ cord-010119-t1x9gknd 11582 13 rate rate NN cord-010119-t1x9gknd 11582 14 decreased decrease VBD cord-010119-t1x9gknd 11582 15 from from IN cord-010119-t1x9gknd 11582 16 29 29 CD cord-010119-t1x9gknd 11582 17 % % NN cord-010119-t1x9gknd 11582 18 to to TO cord-010119-t1x9gknd 11582 19 15 15 CD cord-010119-t1x9gknd 11582 20 % % NN cord-010119-t1x9gknd 11582 21 ( ( -LRB- cord-010119-t1x9gknd 11582 22 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 11582 23 ) ) -RRB- cord-010119-t1x9gknd 11582 24 . . . cord-010119-t1x9gknd 11583 1 Ad ad NN cord-010119-t1x9gknd 11583 2 - - HYPH cord-010119-t1x9gknd 11583 3 hoc hoc FW cord-010119-t1x9gknd 11583 4 ordering ordering NN cord-010119-t1x9gknd 11583 5 was be VBD cord-010119-t1x9gknd 11583 6 not not RB cord-010119-t1x9gknd 11583 7 statistically statistically RB cord-010119-t1x9gknd 11583 8 different different JJ cord-010119-t1x9gknd 11583 9 between between IN cord-010119-t1x9gknd 11583 10 study study NN cord-010119-t1x9gknd 11583 11 periods period NNS cord-010119-t1x9gknd 11583 12 ( ( -LRB- cord-010119-t1x9gknd 11583 13 p50.10 p50.10 NNS cord-010119-t1x9gknd 11583 14 ) ) -RRB- cord-010119-t1x9gknd 11583 15 . . . cord-010119-t1x9gknd 11584 1 The the DT cord-010119-t1x9gknd 11584 2 average average JJ cord-010119-t1x9gknd 11584 3 number number NN cord-010119-t1x9gknd 11584 4 of of IN cord-010119-t1x9gknd 11584 5 AP AP NNP cord-010119-t1x9gknd 11584 6 transfusions transfusion NNS cord-010119-t1x9gknd 11584 7 per per IN cord-010119-t1x9gknd 11584 8 patient patient NN cord-010119-t1x9gknd 11584 9 between between IN cord-010119-t1x9gknd 11584 10 pre pre JJ cord-010119-t1x9gknd 11584 11 - - JJ cord-010119-t1x9gknd 11584 12 and and CC cord-010119-t1x9gknd 11584 13 post post JJ cord-010119-t1x9gknd 11584 14 - - JJ cord-010119-t1x9gknd 11584 15 implementation implementation JJ cord-010119-t1x9gknd 11584 16 periods period NNS cord-010119-t1x9gknd 11584 17 was be VBD cord-010119-t1x9gknd 11584 18 not not RB cord-010119-t1x9gknd 11584 19 statistically statistically RB cord-010119-t1x9gknd 11584 20 different different JJ cord-010119-t1x9gknd 11584 21 ( ( -LRB- cord-010119-t1x9gknd 11584 22 2.1 2.1 CD cord-010119-t1x9gknd 11584 23 and and CC cord-010119-t1x9gknd 11584 24 1.9 1.9 CD cord-010119-t1x9gknd 11584 25 , , , cord-010119-t1x9gknd 11584 26 respectively respectively RB cord-010119-t1x9gknd 11584 27 , , , cord-010119-t1x9gknd 11584 28 p50.65 p50.65 NNP cord-010119-t1x9gknd 11584 29 ) ) -RRB- cord-010119-t1x9gknd 11584 30 . . . cord-010119-t1x9gknd 11585 1 Furthermore furthermore RB cord-010119-t1x9gknd 11585 2 , , , cord-010119-t1x9gknd 11585 3 a a DT cord-010119-t1x9gknd 11585 4 new new JJ cord-010119-t1x9gknd 11585 5 " " `` cord-010119-t1x9gknd 11585 6 rejection rejection NN cord-010119-t1x9gknd 11585 7 threshold threshold NN cord-010119-t1x9gknd 11585 8 " " '' cord-010119-t1x9gknd 11585 9 for for IN cord-010119-t1x9gknd 11585 10 lipaemic lipaemic JJ cord-010119-t1x9gknd 11585 11 products product NNS cord-010119-t1x9gknd 11585 12 will will MD cord-010119-t1x9gknd 11585 13 be be VB cord-010119-t1x9gknd 11585 14 implemented implement VBN cord-010119-t1x9gknd 11585 15 . . . cord-010119-t1x9gknd 11586 1 This this DT cord-010119-t1x9gknd 11586 2 threshold threshold NN cord-010119-t1x9gknd 11586 3 represents represent VBZ cord-010119-t1x9gknd 11586 4 the the DT cord-010119-t1x9gknd 11586 5 TG TG NNP cord-010119-t1x9gknd 11586 6 concentration concentration NN cord-010119-t1x9gknd 11586 7 above above IN cord-010119-t1x9gknd 11586 8 which which WDT cord-010119-t1x9gknd 11586 9 viral viral JJ cord-010119-t1x9gknd 11586 10 marker marker NN cord-010119-t1x9gknd 11586 11 testing testing NN cord-010119-t1x9gknd 11586 12 for for IN cord-010119-t1x9gknd 11586 13 donor donor NN cord-010119-t1x9gknd 11586 14 screening screening NN cord-010119-t1x9gknd 11586 15 will will MD cord-010119-t1x9gknd 11586 16 be be VB cord-010119-t1x9gknd 11586 17 affected affect VBN cord-010119-t1x9gknd 11586 18 . . . cord-010119-t1x9gknd 11587 1 In in IN cord-010119-t1x9gknd 11587 2 KCBB KCBB NNP cord-010119-t1x9gknd 11588 1 Abbott Abbott NNP cord-010119-t1x9gknd 11588 2 's 's POS cord-010119-t1x9gknd 11588 3 Prism Prism NNP cord-010119-t1x9gknd 11588 4 Assays Assays NNPS cord-010119-t1x9gknd 11588 5 are be VBP cord-010119-t1x9gknd 11588 6 used use VBN cord-010119-t1x9gknd 11588 7 for for IN cord-010119-t1x9gknd 11588 8 : : : cord-010119-t1x9gknd 11588 9 HBsAg hbsag ADD cord-010119-t1x9gknd 11588 10 , , , cord-010119-t1x9gknd 11588 11 anti anti JJ cord-010119-t1x9gknd 11588 12 - - JJ cord-010119-t1x9gknd 11588 13 HCV HCV NNP cord-010119-t1x9gknd 11588 14 Ab Ab NNP cord-010119-t1x9gknd 11588 15 , , , cord-010119-t1x9gknd 11588 16 anti anti JJ cord-010119-t1x9gknd 11588 17 - - JJ cord-010119-t1x9gknd 11588 18 HIV HIV NNP cord-010119-t1x9gknd 11588 19 Ab Ab NNP cord-010119-t1x9gknd 11588 20 , , , cord-010119-t1x9gknd 11588 21 anti anti JJ cord-010119-t1x9gknd 11588 22 - - JJ cord-010119-t1x9gknd 11588 23 HTLVI HTLVI NNP cord-010119-t1x9gknd 11588 24 / / SYM cord-010119-t1x9gknd 11588 25 II II NNP cord-010119-t1x9gknd 11588 26 . . . cord-010119-t1x9gknd 11589 1 Results result NNS cord-010119-t1x9gknd 11589 2 / / SYM cord-010119-t1x9gknd 11589 3 Finding finding NN cord-010119-t1x9gknd 11589 4 : : : cord-010119-t1x9gknd 11590 1 Using use VBG cord-010119-t1x9gknd 11590 2 data data NN cord-010119-t1x9gknd 11590 3 management management NN cord-010119-t1x9gknd 11590 4 system system NN cord-010119-t1x9gknd 11590 5 and and CC cord-010119-t1x9gknd 11590 6 file file NN cord-010119-t1x9gknd 11590 7 records record NNS cord-010119-t1x9gknd 11590 8 in in IN cord-010119-t1x9gknd 11590 9 KCBB KCBB NNP cord-010119-t1x9gknd 11590 10 as as IN cord-010119-t1x9gknd 11590 11 regard regard NN cord-010119-t1x9gknd 11590 12 discarding discard VBG cord-010119-t1x9gknd 11590 13 blood blood NN cord-010119-t1x9gknd 11590 14 components component NNS cord-010119-t1x9gknd 11590 15 due due JJ cord-010119-t1x9gknd 11590 16 to to IN cord-010119-t1x9gknd 11590 17 lipaemia lipaemia NNP cord-010119-t1x9gknd 11590 18 during during IN cord-010119-t1x9gknd 11590 19 the the DT cord-010119-t1x9gknd 11590 20 last last JJ cord-010119-t1x9gknd 11590 21 five five CD cord-010119-t1x9gknd 11590 22 years year NNS cord-010119-t1x9gknd 11590 23 ( ( -LRB- cord-010119-t1x9gknd 11590 24 2012 2012 CD cord-010119-t1x9gknd 11590 25 ) ) -RRB- cord-010119-t1x9gknd 11591 1 ( ( -LRB- cord-010119-t1x9gknd 11591 2 2013 2013 CD cord-010119-t1x9gknd 11591 3 ) ) -RRB- cord-010119-t1x9gknd 11592 1 ( ( -LRB- cord-010119-t1x9gknd 11592 2 2014 2014 CD cord-010119-t1x9gknd 11592 3 ) ) -RRB- cord-010119-t1x9gknd 11592 4 ( ( -LRB- cord-010119-t1x9gknd 11592 5 2015 2015 CD cord-010119-t1x9gknd 11592 6 ) ) -RRB- cord-010119-t1x9gknd 11592 7 ( ( -LRB- cord-010119-t1x9gknd 11592 8 2016 2016 CD cord-010119-t1x9gknd 11592 9 ) ) -RRB- cord-010119-t1x9gknd 11592 10 , , , cord-010119-t1x9gknd 11592 11 it -PRON- PRP cord-010119-t1x9gknd 11592 12 was be VBD cord-010119-t1x9gknd 11592 13 demonstrated demonstrate VBN cord-010119-t1x9gknd 11592 14 that that IN cord-010119-t1x9gknd 11592 15 number number NN cord-010119-t1x9gknd 11592 16 of of IN cord-010119-t1x9gknd 11592 17 discarded discard VBN cord-010119-t1x9gknd 11592 18 RBCs rbc NNS cord-010119-t1x9gknd 11592 19 due due JJ cord-010119-t1x9gknd 11592 20 to to IN cord-010119-t1x9gknd 11592 21 lipaemia lipaemia NNP cord-010119-t1x9gknd 11592 22 during during IN cord-010119-t1x9gknd 11592 23 the the DT cord-010119-t1x9gknd 11592 24 whole whole JJ cord-010119-t1x9gknd 11592 25 period period NN cord-010119-t1x9gknd 11592 26 was be VBD cord-010119-t1x9gknd 11592 27 4892 4892 CD cord-010119-t1x9gknd 11592 28 units unit NNS cord-010119-t1x9gknd 11592 29 . . . cord-010119-t1x9gknd 11593 1 Number number NN cord-010119-t1x9gknd 11593 2 of of IN cord-010119-t1x9gknd 11593 3 discarded discard VBN cord-010119-t1x9gknd 11593 4 different different JJ cord-010119-t1x9gknd 11593 5 plasma plasma NN cord-010119-t1x9gknd 11593 6 , , , cord-010119-t1x9gknd 11593 7 platelets platelet NNS cord-010119-t1x9gknd 11593 8 , , , cord-010119-t1x9gknd 11593 9 and and CC cord-010119-t1x9gknd 11593 10 cryoprecipitate cryoprecipitate NN cord-010119-t1x9gknd 11593 11 components component NNS cord-010119-t1x9gknd 11593 12 during during IN cord-010119-t1x9gknd 11593 13 the the DT cord-010119-t1x9gknd 11593 14 last last JJ cord-010119-t1x9gknd 11593 15 two two CD cord-010119-t1x9gknd 11593 16 years year NNS cord-010119-t1x9gknd 11593 17 due due JJ cord-010119-t1x9gknd 11593 18 to to IN cord-010119-t1x9gknd 11593 19 lipaemia lipaemia NNP cord-010119-t1x9gknd 11593 20 was be VBD cord-010119-t1x9gknd 11593 21 8546 8546 CD cord-010119-t1x9gknd 11593 22 , , , cord-010119-t1x9gknd 11593 23 24 24 CD cord-010119-t1x9gknd 11593 24 , , , cord-010119-t1x9gknd 11593 25 and and CC cord-010119-t1x9gknd 11593 26 2 2 CD cord-010119-t1x9gknd 11593 27 units unit NNS cord-010119-t1x9gknd 11593 28 respectively respectively RB cord-010119-t1x9gknd 11593 29 . . . cord-010119-t1x9gknd 11594 1 The the DT cord-010119-t1x9gknd 11594 2 mean mean JJ cord-010119-t1x9gknd 11594 3 number number NN cord-010119-t1x9gknd 11594 4 of of IN cord-010119-t1x9gknd 11594 5 discarded discard VBN cord-010119-t1x9gknd 11594 6 RBC RBC NNP cord-010119-t1x9gknd 11594 7 units unit NNS cord-010119-t1x9gknd 11594 8 of of IN cord-010119-t1x9gknd 11594 9 the the DT cord-010119-t1x9gknd 11594 10 five five CD cord-010119-t1x9gknd 11594 11 years year NNS cord-010119-t1x9gknd 11594 12 of of IN cord-010119-t1x9gknd 11594 13 the the DT cord-010119-t1x9gknd 11594 14 study study NN cord-010119-t1x9gknd 11594 15 exceeds exceed VBZ cord-010119-t1x9gknd 11594 16 50 50 CD cord-010119-t1x9gknd 11594 17 % % NN cord-010119-t1x9gknd 11594 18 of of IN cord-010119-t1x9gknd 11594 19 the the DT cord-010119-t1x9gknd 11594 20 tested test VBN cord-010119-t1x9gknd 11594 21 ones one NNS cord-010119-t1x9gknd 11594 22 . . . cord-010119-t1x9gknd 11595 1 Literature literature NN cord-010119-t1x9gknd 11595 2 about about IN cord-010119-t1x9gknd 11595 3 guidelines guideline NNS cord-010119-t1x9gknd 11595 4 on on IN cord-010119-t1x9gknd 11595 5 the the DT cord-010119-t1x9gknd 11595 6 management management NN cord-010119-t1x9gknd 11595 7 of of IN cord-010119-t1x9gknd 11595 8 lipaemic lipaemic JJ cord-010119-t1x9gknd 11595 9 donations donation NNS cord-010119-t1x9gknd 11595 10 were be VBD cord-010119-t1x9gknd 11595 11 reviewed review VBN cord-010119-t1x9gknd 11595 12 in in IN cord-010119-t1x9gknd 11595 13 order order NN cord-010119-t1x9gknd 11595 14 to to TO cord-010119-t1x9gknd 11595 15 minimize minimize VB cord-010119-t1x9gknd 11595 16 donation donation NN cord-010119-t1x9gknd 11595 17 loss loss NN cord-010119-t1x9gknd 11595 18 , , , cord-010119-t1x9gknd 11595 19 and and CC cord-010119-t1x9gknd 11595 20 establish establish VB cord-010119-t1x9gknd 11595 21 an an DT cord-010119-t1x9gknd 11595 22 accurate accurate JJ cord-010119-t1x9gknd 11595 23 rejection rejection NN cord-010119-t1x9gknd 11595 24 threshold threshold NN cord-010119-t1x9gknd 11595 25 for for IN cord-010119-t1x9gknd 11595 26 lipaemic lipaemic JJ cord-010119-t1x9gknd 11595 27 donations donation NNS cord-010119-t1x9gknd 11595 28 . . . cord-010119-t1x9gknd 11596 1 By by IN cord-010119-t1x9gknd 11596 2 reviewing review VBG cord-010119-t1x9gknd 11596 3 sample sample NN cord-010119-t1x9gknd 11596 4 requirements requirement NNS cord-010119-t1x9gknd 11596 5 for for IN cord-010119-t1x9gknd 11596 6 viral viral JJ cord-010119-t1x9gknd 11596 7 marker marker NN cord-010119-t1x9gknd 11596 8 testing testing NN cord-010119-t1x9gknd 11596 9 in in IN cord-010119-t1x9gknd 11596 10 KCBB KCBB NNP cord-010119-t1x9gknd 11596 11 , , , cord-010119-t1x9gknd 11596 12 the the DT cord-010119-t1x9gknd 11596 13 accepted accepted JJ cord-010119-t1x9gknd 11596 14 level level NN cord-010119-t1x9gknd 11596 15 for for IN cord-010119-t1x9gknd 11596 16 TG TG NNP cord-010119-t1x9gknd 11596 17 in in IN cord-010119-t1x9gknd 11596 18 blood blood NN cord-010119-t1x9gknd 11596 19 samples sample NNS cord-010119-t1x9gknd 11596 20 is be VBZ cord-010119-t1x9gknd 11596 21 below below IN cord-010119-t1x9gknd 11596 22 1000 1000 CD cord-010119-t1x9gknd 11596 23 mg mg NNP cord-010119-t1x9gknd 11596 24 / / SYM cord-010119-t1x9gknd 11596 25 dL dl NN cord-010119-t1x9gknd 11596 26 , , , cord-010119-t1x9gknd 11596 27 and and CC cord-010119-t1x9gknd 11596 28 so so RB cord-010119-t1x9gknd 11596 29 the the DT cord-010119-t1x9gknd 11596 30 rejection rejection NN cord-010119-t1x9gknd 11596 31 threshold threshold NN cord-010119-t1x9gknd 11596 32 for for IN cord-010119-t1x9gknd 11596 33 lipaemia lipaemia NNP cord-010119-t1x9gknd 11596 34 is be VBZ cord-010119-t1x9gknd 11596 35 level level NN cord-010119-t1x9gknd 11596 36 equal equal JJ cord-010119-t1x9gknd 11596 37 to to IN cord-010119-t1x9gknd 11596 38 or or CC cord-010119-t1x9gknd 11596 39 more more JJR cord-010119-t1x9gknd 11596 40 than than IN cord-010119-t1x9gknd 11596 41 1000 1000 CD cord-010119-t1x9gknd 11597 1 mg mg NNP cord-010119-t1x9gknd 11597 2 / / SYM cord-010119-t1x9gknd 11597 3 dL. dL. NNP cord-010119-t1x9gknd 11597 4 Conclusion conclusion NN cord-010119-t1x9gknd 11597 5 : : : cord-010119-t1x9gknd 11597 6 Many many JJ cord-010119-t1x9gknd 11597 7 blood blood NN cord-010119-t1x9gknd 11597 8 product product NN cord-010119-t1x9gknd 11597 9 units unit NNS cord-010119-t1x9gknd 11597 10 are be VBP cord-010119-t1x9gknd 11597 11 discarded discard VBN cord-010119-t1x9gknd 11597 12 needlessly needlessly RB cord-010119-t1x9gknd 11597 13 in in IN cord-010119-t1x9gknd 11597 14 KCBB KCBB NNP cord-010119-t1x9gknd 11597 15 due due IN cord-010119-t1x9gknd 11597 16 to to IN cord-010119-t1x9gknd 11597 17 lipaemia lipaemia NNP cord-010119-t1x9gknd 11597 18 in in IN cord-010119-t1x9gknd 11597 19 the the DT cord-010119-t1x9gknd 11597 20 last last JJ cord-010119-t1x9gknd 11597 21 five five CD cord-010119-t1x9gknd 11597 22 years year NNS cord-010119-t1x9gknd 11597 23 ( ( -LRB- cord-010119-t1x9gknd 11597 24 including include VBG cord-010119-t1x9gknd 11597 25 4892 4892 CD cord-010119-t1x9gknd 11597 26 RBCs rbc NNS cord-010119-t1x9gknd 11597 27 , , , cord-010119-t1x9gknd 11597 28 8546 8546 CD cord-010119-t1x9gknd 11597 29 plasma plasma NN cord-010119-t1x9gknd 11597 30 products product NNS cord-010119-t1x9gknd 11597 31 and and CC cord-010119-t1x9gknd 11597 32 24 24 CD cord-010119-t1x9gknd 11597 33 apheresis apheresis NN cord-010119-t1x9gknd 11597 34 platelet platelet NN cord-010119-t1x9gknd 11597 35 units unit NNS cord-010119-t1x9gknd 11597 36 ) ) -RRB- cord-010119-t1x9gknd 11597 37 . . . cord-010119-t1x9gknd 11598 1 In in IN cord-010119-t1x9gknd 11598 2 an an DT cord-010119-t1x9gknd 11598 3 effort effort NN cord-010119-t1x9gknd 11598 4 to to TO cord-010119-t1x9gknd 11598 5 reduce reduce VB cord-010119-t1x9gknd 11598 6 the the DT cord-010119-t1x9gknd 11598 7 waste waste NN cord-010119-t1x9gknd 11598 8 of of IN cord-010119-t1x9gknd 11598 9 potentially potentially RB cord-010119-t1x9gknd 11598 10 lifesaving lifesaving JJ cord-010119-t1x9gknd 11598 11 products product NNS cord-010119-t1x9gknd 11598 12 , , , cord-010119-t1x9gknd 11598 13 the the DT cord-010119-t1x9gknd 11598 14 rejection rejection NN cord-010119-t1x9gknd 11598 15 threshold threshold NN cord-010119-t1x9gknd 11598 16 for for IN cord-010119-t1x9gknd 11598 17 lipaemic lipaemic JJ cord-010119-t1x9gknd 11598 18 products product NNS cord-010119-t1x9gknd 11598 19 is be VBZ cord-010119-t1x9gknd 11598 20 recommended recommend VBN cord-010119-t1x9gknd 11598 21 to to TO cord-010119-t1x9gknd 11598 22 be be VB cord-010119-t1x9gknd 11598 23 changed change VBN cord-010119-t1x9gknd 11598 24 from from IN cord-010119-t1x9gknd 11598 25 200 200 CD cord-010119-t1x9gknd 11598 26 mg mg NNP cord-010119-t1x9gknd 11598 27 / / SYM cord-010119-t1x9gknd 11598 28 dL dl NN cord-010119-t1x9gknd 11598 29 to to IN cord-010119-t1x9gknd 11598 30 1000 1000 CD cord-010119-t1x9gknd 11598 31 mg mg NNP cord-010119-t1x9gknd 11598 32 / / SYM cord-010119-t1x9gknd 11598 33 dL dL NNP cord-010119-t1x9gknd 11598 34 which which WDT cord-010119-t1x9gknd 11598 35 does do VBZ cord-010119-t1x9gknd 11598 36 not not RB cord-010119-t1x9gknd 11598 37 affect affect VB cord-010119-t1x9gknd 11598 38 blood blood NN cord-010119-t1x9gknd 11598 39 safety safety NN cord-010119-t1x9gknd 11598 40 . . . cord-010119-t1x9gknd 11599 1 A a DT cord-010119-t1x9gknd 11599 2 follow follow NN cord-010119-t1x9gknd 11599 3 up up RP cord-010119-t1x9gknd 11599 4 study study NN cord-010119-t1x9gknd 11599 5 is be VBZ cord-010119-t1x9gknd 11599 6 recommended recommend VBN cord-010119-t1x9gknd 11599 7 after after IN cord-010119-t1x9gknd 11599 8 applying apply VBG cord-010119-t1x9gknd 11599 9 the the DT cord-010119-t1x9gknd 11599 10 new new JJ cord-010119-t1x9gknd 11599 11 threshold threshold NN cord-010119-t1x9gknd 11599 12 to to TO cord-010119-t1x9gknd 11599 13 evaluate evaluate VB cord-010119-t1x9gknd 11599 14 the the DT cord-010119-t1x9gknd 11599 15 new new JJ cord-010119-t1x9gknd 11599 16 policy policy NN cord-010119-t1x9gknd 11599 17 . . . cord-010119-t1x9gknd 11600 1 Logistical Logistical NNP cord-010119-t1x9gknd 11600 2 Management Management NNP cord-010119-t1x9gknd 11600 3 of of IN cord-010119-t1x9gknd 11600 4 the the DT cord-010119-t1x9gknd 11600 5 Incorporation Incorporation NNP cord-010119-t1x9gknd 11600 6 of of IN cord-010119-t1x9gknd 11600 7 Pathogen Pathogen NNP cord-010119-t1x9gknd 11600 8 Reduced Reduced NNP cord-010119-t1x9gknd 11600 9 Single Single NNP cord-010119-t1x9gknd 11600 10 Donor Donor NNP cord-010119-t1x9gknd 11600 11 Platelets platelet NNS cord-010119-t1x9gknd 11600 12 ( ( -LRB- cord-010119-t1x9gknd 11600 13 PR PR NNP cord-010119-t1x9gknd 11600 14 - - HYPH cord-010119-t1x9gknd 11600 15 SDP SDP NNP cord-010119-t1x9gknd 11600 16 ) ) -RRB- cord-010119-t1x9gknd 11600 17 into into IN cord-010119-t1x9gknd 11600 18 Inventory Inventory NNP cord-010119-t1x9gknd 11600 19 at at IN cord-010119-t1x9gknd 11600 20 a a DT cord-010119-t1x9gknd 11600 21 U.S. U.S. NNP cord-010119-t1x9gknd 11600 22 Tertiary Tertiary NNP cord-010119-t1x9gknd 11600 23 Care Care NNP cord-010119-t1x9gknd 11600 24 Medical Medical NNP cord-010119-t1x9gknd 11600 25 Center Center NNP cord-010119-t1x9gknd 11600 26 Eric Eric NNP cord-010119-t1x9gknd 11600 27 Gehrie Gehrie NNP cord-010119-t1x9gknd 11600 28 * * NFP cord-010119-t1x9gknd 11600 29 1,2 1,2 CD cord-010119-t1x9gknd 11600 30 , , , cord-010119-t1x9gknd 11600 31 Rebecca Rebecca NNP cord-010119-t1x9gknd 11600 32 Ross Ross NNP cord-010119-t1x9gknd 11600 33 3 3 CD cord-010119-t1x9gknd 11600 34 , , , cord-010119-t1x9gknd 11600 35 Debra Debra NNP cord-010119-t1x9gknd 11600 36 Mraz Mraz NNP cord-010119-t1x9gknd 11600 37 3 3 CD cord-010119-t1x9gknd 11600 38 , , , cord-010119-t1x9gknd 11600 39 Anne Anne NNP cord-010119-t1x9gknd 11600 40 Baker Baker NNP cord-010119-t1x9gknd 11600 41 3 3 CD cord-010119-t1x9gknd 11600 42 , , , cord-010119-t1x9gknd 11600 43 Zenna Zenna NNP cord-010119-t1x9gknd 11600 44 Neal Neal NNP cord-010119-t1x9gknd 11600 45 3 3 CD cord-010119-t1x9gknd 11600 46 , , , cord-010119-t1x9gknd 11600 47 Melanie Melanie NNP cord-010119-t1x9gknd 11600 48 Champion Champion NNP cord-010119-t1x9gknd 11600 49 3 3 NNP cord-010119-t1x9gknd 11600 50 and and CC cord-010119-t1x9gknd 11600 51 Edward Edward NNP cord-010119-t1x9gknd 11600 52 L. L. NNP cord-010119-t1x9gknd 11600 53 Snyder Snyder NNP cord-010119-t1x9gknd 11601 1 2,3 2,3 LS cord-010119-t1x9gknd 11601 2 . . . cord-010119-t1x9gknd 11602 1 1 1 LS cord-010119-t1x9gknd 11603 1 Johns Johns NNP cord-010119-t1x9gknd 11603 2 Hopkins Hopkins NNP cord-010119-t1x9gknd 11603 3 University University NNP cord-010119-t1x9gknd 11603 4 School School NNP cord-010119-t1x9gknd 11603 5 of of IN cord-010119-t1x9gknd 11603 6 Medicine Medicine NNP cord-010119-t1x9gknd 11603 7 , , , cord-010119-t1x9gknd 11603 8 2 2 CD cord-010119-t1x9gknd 11603 9 Yale Yale NNP cord-010119-t1x9gknd 11603 10 University University NNP cord-010119-t1x9gknd 11603 11 , , , cord-010119-t1x9gknd 11603 12 3 3 CD cord-010119-t1x9gknd 11603 13 Yale Yale NNP cord-010119-t1x9gknd 11603 14 - - HYPH cord-010119-t1x9gknd 11603 15 New New NNP cord-010119-t1x9gknd 11603 16 Haven Haven NNP cord-010119-t1x9gknd 11603 17 Hospital Hospital NNP cord-010119-t1x9gknd 11603 18 Background Background NNP cord-010119-t1x9gknd 11603 19 / / SYM cord-010119-t1x9gknd 11603 20 Case Case NNP cord-010119-t1x9gknd 11603 21 Studies Studies NNPS cord-010119-t1x9gknd 11603 22 : : : cord-010119-t1x9gknd 11604 1 The the DT cord-010119-t1x9gknd 11604 2 approval approval NN cord-010119-t1x9gknd 11604 3 of of IN cord-010119-t1x9gknd 11604 4 PR PR NNP cord-010119-t1x9gknd 11604 5 - - HYPH cord-010119-t1x9gknd 11604 6 SDP SDP NNP cord-010119-t1x9gknd 11604 7 by by IN cord-010119-t1x9gknd 11604 8 the the DT cord-010119-t1x9gknd 11604 9 FDA FDA NNP cord-010119-t1x9gknd 11604 10 provided provide VBD cord-010119-t1x9gknd 11604 11 an an DT cord-010119-t1x9gknd 11604 12 opportunity opportunity NN cord-010119-t1x9gknd 11604 13 to to TO cord-010119-t1x9gknd 11604 14 improve improve VB cord-010119-t1x9gknd 11604 15 the the DT cord-010119-t1x9gknd 11604 16 safety safety NN cord-010119-t1x9gknd 11604 17 of of IN cord-010119-t1x9gknd 11604 18 our -PRON- PRP$ cord-010119-t1x9gknd 11604 19 platelet platelet NN cord-010119-t1x9gknd 11604 20 inventory inventory NN cord-010119-t1x9gknd 11604 21 across across IN cord-010119-t1x9gknd 11604 22 all all DT cord-010119-t1x9gknd 11604 23 patient patient JJ cord-010119-t1x9gknd 11604 24 demographics demographic NNS cord-010119-t1x9gknd 11604 25 . . . cord-010119-t1x9gknd 11605 1 We -PRON- PRP cord-010119-t1x9gknd 11605 2 outline outline VBP cord-010119-t1x9gknd 11605 3 our -PRON- PRP$ cord-010119-t1x9gknd 11605 4 approach approach NN cord-010119-t1x9gknd 11605 5 and and CC cord-010119-t1x9gknd 11605 6 address address NN cord-010119-t1x9gknd 11605 7 issues issue NNS cord-010119-t1x9gknd 11605 8 we -PRON- PRP cord-010119-t1x9gknd 11605 9 faced face VBD cord-010119-t1x9gknd 11605 10 during during IN cord-010119-t1x9gknd 11605 11 the the DT cord-010119-t1x9gknd 11605 12 first first JJ cord-010119-t1x9gknd 11605 13 4 4 CD cord-010119-t1x9gknd 11605 14 months month NNS cord-010119-t1x9gknd 11605 15 of of IN cord-010119-t1x9gknd 11605 16 PR PR NNP cord-010119-t1x9gknd 11605 17 - - HYPH cord-010119-t1x9gknd 11605 18 SDP sdp NN cord-010119-t1x9gknd 11605 19 availability availability NN cord-010119-t1x9gknd 11605 20 . . . cord-010119-t1x9gknd 11606 1 Study Study NNP cord-010119-t1x9gknd 11606 2 Design Design NNP cord-010119-t1x9gknd 11606 3 / / SYM cord-010119-t1x9gknd 11606 4 Methods method NNS cord-010119-t1x9gknd 11606 5 : : : cord-010119-t1x9gknd 11606 6 Our -PRON- PRP$ cord-010119-t1x9gknd 11606 7 nursing nursing NN cord-010119-t1x9gknd 11606 8 education education NN cord-010119-t1x9gknd 11606 9 team team NN cord-010119-t1x9gknd 11606 10 provided provide VBD cord-010119-t1x9gknd 11606 11 presentations presentation NNS cord-010119-t1x9gknd 11606 12 to to IN cord-010119-t1x9gknd 11606 13 the the DT cord-010119-t1x9gknd 11606 14 nursing nursing NN cord-010119-t1x9gknd 11606 15 and and CC cord-010119-t1x9gknd 11606 16 clinical clinical JJ cord-010119-t1x9gknd 11606 17 unit unit NN cord-010119-t1x9gknd 11606 18 support support NN cord-010119-t1x9gknd 11606 19 staff staff NN cord-010119-t1x9gknd 11606 20 . . . cord-010119-t1x9gknd 11607 1 A a DT cord-010119-t1x9gknd 11607 2 company company NN cord-010119-t1x9gknd 11607 3 - - HYPH cord-010119-t1x9gknd 11607 4 sponsored sponsor VBN cord-010119-t1x9gknd 11607 5 trainer trainer NN cord-010119-t1x9gknd 11607 6 staffed staffed JJ cord-010119-t1x9gknd 11607 7 sessions session NNS cord-010119-t1x9gknd 11607 8 for for IN cord-010119-t1x9gknd 11607 9 the the DT cord-010119-t1x9gknd 11607 10 evening evening NN cord-010119-t1x9gknd 11607 11 / / SYM cord-010119-t1x9gknd 11607 12 night night NN cord-010119-t1x9gknd 11607 13 shifts shift NNS cord-010119-t1x9gknd 11607 14 on on IN cord-010119-t1x9gknd 11607 15 the the DT cord-010119-t1x9gknd 11607 16 clinical clinical JJ cord-010119-t1x9gknd 11607 17 wards ward NNS cord-010119-t1x9gknd 11607 18 . . . cord-010119-t1x9gknd 11608 1 Presentations presentation NNS cord-010119-t1x9gknd 11608 2 to to IN cord-010119-t1x9gknd 11608 3 physicians physician NNS cord-010119-t1x9gknd 11608 4 were be VBD cord-010119-t1x9gknd 11608 5 made make VBN cord-010119-t1x9gknd 11608 6 by by IN cord-010119-t1x9gknd 11608 7 the the DT cord-010119-t1x9gknd 11608 8 blood blood NN cord-010119-t1x9gknd 11608 9 bank bank NN cord-010119-t1x9gknd 11608 10 medical medical JJ cord-010119-t1x9gknd 11608 11 staff staff NN cord-010119-t1x9gknd 11608 12 . . . cord-010119-t1x9gknd 11609 1 Information Information NNP cord-010119-t1x9gknd 11609 2 Technology Technology NNP cord-010119-t1x9gknd 11609 3 personnel personnel NNS cord-010119-t1x9gknd 11609 4 created create VBD cord-010119-t1x9gknd 11609 5 a a DT cord-010119-t1x9gknd 11609 6 new new JJ cord-010119-t1x9gknd 11609 7 product product NN cord-010119-t1x9gknd 11609 8 type type NN cord-010119-t1x9gknd 11609 9 in in IN cord-010119-t1x9gknd 11609 10 the the DT cord-010119-t1x9gknd 11609 11 blood blood NN cord-010119-t1x9gknd 11609 12 bank bank NN cord-010119-t1x9gknd 11609 13 computer computer NN cord-010119-t1x9gknd 11609 14 system system NN cord-010119-t1x9gknd 11609 15 , , , cord-010119-t1x9gknd 11609 16 tested test VBD cord-010119-t1x9gknd 11609 17 the the DT cord-010119-t1x9gknd 11609 18 ABO ABO NNP cord-010119-t1x9gknd 11609 19 / / SYM cord-010119-t1x9gknd 11609 20 Rh Rh NNP cord-010119-t1x9gknd 11609 21 truth truth NN cord-010119-t1x9gknd 11609 22 tables table NNS cord-010119-t1x9gknd 11609 23 , , , cord-010119-t1x9gknd 11609 24 and and CC cord-010119-t1x9gknd 11609 25 ensured ensure VBD cord-010119-t1x9gknd 11609 26 that that IN cord-010119-t1x9gknd 11609 27 billing billing NN cord-010119-t1x9gknd 11609 28 codes code NNS cord-010119-t1x9gknd 11609 29 were be VBD cord-010119-t1x9gknd 11609 30 in in IN cord-010119-t1x9gknd 11609 31 place place NN cord-010119-t1x9gknd 11609 32 . . . cord-010119-t1x9gknd 11610 1 The the DT cord-010119-t1x9gknd 11610 2 necessity necessity NN cord-010119-t1x9gknd 11610 3 for for IN cord-010119-t1x9gknd 11610 4 transiently transiently RB cord-010119-t1x9gknd 11610 5 supporting support VBG cord-010119-t1x9gknd 11610 6 a a DT cord-010119-t1x9gknd 11610 7 dual dual JJ cord-010119-t1x9gknd 11610 8 inventory inventory NN cord-010119-t1x9gknd 11610 9 of of IN cord-010119-t1x9gknd 11610 10 PR PR NNP cord-010119-t1x9gknd 11610 11 - - HYPH cord-010119-t1x9gknd 11610 12 SDP sdp NN cord-010119-t1x9gknd 11610 13 and and CC cord-010119-t1x9gknd 11610 14 conventional conventional JJ cord-010119-t1x9gknd 11610 15 platelets platelet NNS cord-010119-t1x9gknd 11610 16 led lead VBD cord-010119-t1x9gknd 11610 17 to to IN cord-010119-t1x9gknd 11610 18 consultation consultation NN cord-010119-t1x9gknd 11610 19 with with IN cord-010119-t1x9gknd 11610 20 the the DT cord-010119-t1x9gknd 11610 21 ethics ethic NNS cord-010119-t1x9gknd 11610 22 committee committee NNP cord-010119-t1x9gknd 11610 23 and and CC cord-010119-t1x9gknd 11610 24 risk risk NN cord-010119-t1x9gknd 11610 25 management management NN cord-010119-t1x9gknd 11610 26 , , , cord-010119-t1x9gknd 11610 27 to to TO cord-010119-t1x9gknd 11610 28 confirm confirm VB cord-010119-t1x9gknd 11610 29 that that IN cord-010119-t1x9gknd 11610 30 PR PR NNP cord-010119-t1x9gknd 11610 31 - - HYPH cord-010119-t1x9gknd 11610 32 SDP sdp NN cord-010119-t1x9gknd 11610 33 and and CC cord-010119-t1x9gknd 11610 34 conventional conventional JJ cord-010119-t1x9gknd 11610 35 platelets platelet NNS cord-010119-t1x9gknd 11610 36 ( ( -LRB- cord-010119-t1x9gknd 11610 37 C C NNP cord-010119-t1x9gknd 11610 38 - - HYPH cord-010119-t1x9gknd 11610 39 PLTs PLTs NNP cord-010119-t1x9gknd 11610 40 ) ) -RRB- cord-010119-t1x9gknd 11610 41 tested test VBN cord-010119-t1x9gknd 11610 42 for for IN cord-010119-t1x9gknd 11610 43 bacteria bacteria NNS cord-010119-t1x9gknd 11610 44 ( ( -LRB- cord-010119-t1x9gknd 11610 45 " " `` cord-010119-t1x9gknd 11610 46 safety safety NN cord-010119-t1x9gknd 11610 47 measure measure NN cord-010119-t1x9gknd 11610 48 " " '' cord-010119-t1x9gknd 11610 49 testing testing NN cord-010119-t1x9gknd 11610 50 ) ) -RRB- cord-010119-t1x9gknd 11610 51 could could MD cord-010119-t1x9gknd 11610 52 both both DT cord-010119-t1x9gknd 11610 53 be be VB cord-010119-t1x9gknd 11610 54 considered consider VBN cord-010119-t1x9gknd 11610 55 the the DT cord-010119-t1x9gknd 11610 56 hospital hospital NN cord-010119-t1x9gknd 11610 57 standard standard NN cord-010119-t1x9gknd 11610 58 of of IN cord-010119-t1x9gknd 11610 59 care care NN cord-010119-t1x9gknd 11610 60 . . . cord-010119-t1x9gknd 11611 1 We -PRON- PRP cord-010119-t1x9gknd 11611 2 chose choose VBD cord-010119-t1x9gknd 11611 3 to to TO cord-010119-t1x9gknd 11611 4 not not RB cord-010119-t1x9gknd 11611 5 gamma gamma NN cord-010119-t1x9gknd 11611 6 irradiate irradiate VB cord-010119-t1x9gknd 11611 7 any any DT cord-010119-t1x9gknd 11611 8 unit unit NN cord-010119-t1x9gknd 11611 9 of of IN cord-010119-t1x9gknd 11611 10 PR PR NNP cord-010119-t1x9gknd 11611 11 - - HYPH cord-010119-t1x9gknd 11611 12 SDP SDP NNP cord-010119-t1x9gknd 11611 13 , , , cord-010119-t1x9gknd 11611 14 consistent consistent JJ cord-010119-t1x9gknd 11611 15 with with IN cord-010119-t1x9gknd 11611 16 the the DT cord-010119-t1x9gknd 11611 17 package package NN cord-010119-t1x9gknd 11611 18 insert insert NN cord-010119-t1x9gknd 11611 19 . . . cord-010119-t1x9gknd 11612 1 Results result NNS cord-010119-t1x9gknd 11612 2 / / SYM cord-010119-t1x9gknd 11612 3 Findings finding NNS cord-010119-t1x9gknd 11612 4 : : : cord-010119-t1x9gknd 11613 1 The the DT cord-010119-t1x9gknd 11613 2 ethics ethic NNS cord-010119-t1x9gknd 11613 3 committee committee NN cord-010119-t1x9gknd 11613 4 and and CC cord-010119-t1x9gknd 11613 5 risk risk NN cord-010119-t1x9gknd 11613 6 management management NN cord-010119-t1x9gknd 11613 7 confirmed confirm VBD cord-010119-t1x9gknd 11613 8 that that IN cord-010119-t1x9gknd 11613 9 informed informed JJ cord-010119-t1x9gknd 11613 10 consent consent NN cord-010119-t1x9gknd 11613 11 was be VBD cord-010119-t1x9gknd 11613 12 not not RB cord-010119-t1x9gknd 11613 13 needed need VBN cord-010119-t1x9gknd 11613 14 for for IN cord-010119-t1x9gknd 11613 15 transfusion transfusion NN cord-010119-t1x9gknd 11613 16 of of IN cord-010119-t1x9gknd 11613 17 PR PR NNP cord-010119-t1x9gknd 11613 18 - - HYPH cord-010119-t1x9gknd 11613 19 SDP SDP NNP cord-010119-t1x9gknd 11613 20 . . . cord-010119-t1x9gknd 11614 1 PR PR NNP cord-010119-t1x9gknd 11614 2 - - HYPH cord-010119-t1x9gknd 11614 3 SDP SDP NNP cord-010119-t1x9gknd 11614 4 available available JJ cord-010119-t1x9gknd 11614 5 from from IN cord-010119-t1x9gknd 11614 6 our -PRON- PRP$ cord-010119-t1x9gknd 11614 7 blood blood NN cord-010119-t1x9gknd 11614 8 supplier supplier NN cord-010119-t1x9gknd 11614 9 incremented incremente VBD cord-010119-t1x9gknd 11614 10 monthly monthly RB cord-010119-t1x9gknd 11614 11 . . . cord-010119-t1x9gknd 11615 1 Over over IN cord-010119-t1x9gknd 11615 2 the the DT cord-010119-t1x9gknd 11615 3 first first JJ cord-010119-t1x9gknd 11615 4 four four CD cord-010119-t1x9gknd 11615 5 months month NNS cord-010119-t1x9gknd 11615 6 of of IN cord-010119-t1x9gknd 11615 7 PR PR NNP cord-010119-t1x9gknd 11615 8 - - HYPH cord-010119-t1x9gknd 11615 9 SDP sdp NN cord-010119-t1x9gknd 11615 10 availability availability NN cord-010119-t1x9gknd 11615 11 , , , cord-010119-t1x9gknd 11615 12 777 777 CD cord-010119-t1x9gknd 11615 13 PR PR NNP cord-010119-t1x9gknd 11615 14 - - HYPH cord-010119-t1x9gknd 11615 15 SDP SDP NNP cord-010119-t1x9gknd 11615 16 were be VBD cord-010119-t1x9gknd 11615 17 transfused transfuse VBN cord-010119-t1x9gknd 11615 18 at at IN cord-010119-t1x9gknd 11615 19 our -PRON- PRP$ cord-010119-t1x9gknd 11615 20 hospital hospital NN cord-010119-t1x9gknd 11615 21 ( ( -LRB- cord-010119-t1x9gknd 11615 22 out out IN cord-010119-t1x9gknd 11615 23 of of IN cord-010119-t1x9gknd 11615 24 a a DT cord-010119-t1x9gknd 11615 25 total total NN cord-010119-t1x9gknd 11615 26 of of IN cord-010119-t1x9gknd 11615 27 3286 3286 CD cord-010119-t1x9gknd 11615 28 platelets platelet NNS cord-010119-t1x9gknd 11615 29 transfused transfuse VBN cord-010119-t1x9gknd 11615 30 ) ) -RRB- cord-010119-t1x9gknd 11615 31 . . . cord-010119-t1x9gknd 11616 1 After after IN cord-010119-t1x9gknd 11616 2 4 4 CD cord-010119-t1x9gknd 11616 3 months month NNS cord-010119-t1x9gknd 11616 4 of of IN cord-010119-t1x9gknd 11616 5 scale scale NN cord-010119-t1x9gknd 11616 6 - - HYPH cord-010119-t1x9gknd 11616 7 up up NN cord-010119-t1x9gknd 11616 8 , , , cord-010119-t1x9gknd 11616 9 PR PR NNP cord-010119-t1x9gknd 11616 10 - - HYPH cord-010119-t1x9gknd 11616 11 SDP SDP NNP cord-010119-t1x9gknd 11616 12 were be VBD cord-010119-t1x9gknd 11616 13 approximately approximately RB cord-010119-t1x9gknd 11616 14 30 30 CD cord-010119-t1x9gknd 11616 15 % % NN cord-010119-t1x9gknd 11616 16 of of IN cord-010119-t1x9gknd 11616 17 inventory inventory NN cord-010119-t1x9gknd 11616 18 . . . cord-010119-t1x9gknd 11617 1 Questions question NNS cord-010119-t1x9gknd 11617 2 received receive VBD cord-010119-t1x9gknd 11617 3 during during IN cord-010119-t1x9gknd 11617 4 the the DT cord-010119-t1x9gknd 11617 5 nursing nursing NN cord-010119-t1x9gknd 11617 6 and and CC cord-010119-t1x9gknd 11617 7 medical medical JJ cord-010119-t1x9gknd 11617 8 conferences conference NNS cord-010119-t1x9gknd 11617 9 related relate VBN cord-010119-t1x9gknd 11617 10 to to IN cord-010119-t1x9gknd 11617 11 : : : cord-010119-t1x9gknd 11617 12 the the DT cord-010119-t1x9gknd 11617 13 risk risk NN cord-010119-t1x9gknd 11617 14 of of IN cord-010119-t1x9gknd 11617 15 bacterial bacterial JJ cord-010119-t1x9gknd 11617 16 contamination contamination NN cord-010119-t1x9gknd 11617 17 with with IN cord-010119-t1x9gknd 11617 18 C C NNP cord-010119-t1x9gknd 11617 19 - - HYPH cord-010119-t1x9gknd 11617 20 PLTs PLTs NNP cord-010119-t1x9gknd 11617 21 vs. vs. IN cord-010119-t1x9gknd 11617 22 PR pr NN cord-010119-t1x9gknd 11617 23 - - HYPH cord-010119-t1x9gknd 11617 24 SDP sdp NN cord-010119-t1x9gknd 11617 25 ; ; : cord-010119-t1x9gknd 11617 26 toxicology toxicology NN cord-010119-t1x9gknd 11617 27 of of IN cord-010119-t1x9gknd 11617 28 the the DT cord-010119-t1x9gknd 11617 29 PR PR NNP cord-010119-t1x9gknd 11617 30 process process NN cord-010119-t1x9gknd 11617 31 ; ; : cord-010119-t1x9gknd 11617 32 scanning scan VBG cord-010119-t1x9gknd 11617 33 PR PR NNP cord-010119-t1x9gknd 11617 34 - - HYPH cord-010119-t1x9gknd 11617 35 SDP SDP NNP cord-010119-t1x9gknd 11617 36 labels label NNS cord-010119-t1x9gknd 11617 37 into into IN cord-010119-t1x9gknd 11617 38 the the DT cord-010119-t1x9gknd 11617 39 electronic electronic JJ cord-010119-t1x9gknd 11617 40 medical medical JJ cord-010119-t1x9gknd 11617 41 record record NN cord-010119-t1x9gknd 11617 42 ; ; : cord-010119-t1x9gknd 11617 43 and and CC cord-010119-t1x9gknd 11617 44 the the DT cord-010119-t1x9gknd 11617 45 need need NN cord-010119-t1x9gknd 11617 46 to to TO cord-010119-t1x9gknd 11617 47 irradiate irradiate VB cord-010119-t1x9gknd 11617 48 PR PR NNP cord-010119-t1x9gknd 11617 49 - - HYPH cord-010119-t1x9gknd 11617 50 SDP SDP NNP cord-010119-t1x9gknd 11617 51 . . . cord-010119-t1x9gknd 11618 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11618 2 use use NN cord-010119-t1x9gknd 11618 3 of of IN cord-010119-t1x9gknd 11618 4 a a DT cord-010119-t1x9gknd 11618 5 " " `` cord-010119-t1x9gknd 11618 6 safety safety NN cord-010119-t1x9gknd 11618 7 measure measure NN cord-010119-t1x9gknd 11618 8 " " '' cord-010119-t1x9gknd 11618 9 addressed address VBD cord-010119-t1x9gknd 11618 10 concern concern NN cord-010119-t1x9gknd 11618 11 over over IN cord-010119-t1x9gknd 11618 12 bacterial bacterial JJ cord-010119-t1x9gknd 11618 13 contamination contamination NN cord-010119-t1x9gknd 11618 14 of of IN cord-010119-t1x9gknd 11618 15 C C NNP cord-010119-t1x9gknd 11618 16 - - HYPH cord-010119-t1x9gknd 11618 17 PLTs PLTs NNP cord-010119-t1x9gknd 11618 18 . . . cord-010119-t1x9gknd 11619 1 Published publish VBN cord-010119-t1x9gknd 11619 2 PR PR NNP cord-010119-t1x9gknd 11619 3 - - HYPH cord-010119-t1x9gknd 11619 4 SDP SDP NNP cord-010119-t1x9gknd 11619 5 toxicology toxicology NN cord-010119-t1x9gknd 11619 6 data datum NNS cord-010119-t1x9gknd 11619 7 comparing compare VBG cord-010119-t1x9gknd 11619 8 the the DT cord-010119-t1x9gknd 11619 9 content content NN cord-010119-t1x9gknd 11619 10 of of IN cord-010119-t1x9gknd 11619 11 psoralens psoralen NNS cord-010119-t1x9gknd 11619 12 in in IN cord-010119-t1x9gknd 11619 13 food food NN cord-010119-t1x9gknd 11619 14 products product NNS cord-010119-t1x9gknd 11619 15 such such JJ cord-010119-t1x9gknd 11619 16 as as IN cord-010119-t1x9gknd 11619 17 grapefruit grapefruit NN cord-010119-t1x9gknd 11619 18 ( ( -LRB- cord-010119-t1x9gknd 11619 19 $ $ $ cord-010119-t1x9gknd 11619 20 12 12 CD cord-010119-t1x9gknd 11619 21 mg mg CD cord-010119-t1x9gknd 11619 22 per per IN cord-010119-t1x9gknd 11619 23 100 100 CD cord-010119-t1x9gknd 11619 24 g g NN cord-010119-t1x9gknd 11619 25 ) ) -RRB- cord-010119-t1x9gknd 11619 26 to to IN cord-010119-t1x9gknd 11619 27 the the DT cord-010119-t1x9gknd 11619 28 content content NN cord-010119-t1x9gknd 11619 29 in in IN cord-010119-t1x9gknd 11619 30 PR PR NNP cord-010119-t1x9gknd 11619 31 - - HYPH cord-010119-t1x9gknd 11619 32 SDP SDP NNP cord-010119-t1x9gknd 11619 33 ( ( -LRB- cord-010119-t1x9gknd 11619 34 < < NNP cord-010119-t1x9gknd 11619 35 1 1 CD cord-010119-t1x9gknd 11619 36 ng ng NN cord-010119-t1x9gknd 11619 37 per per IN cord-010119-t1x9gknd 11619 38 mL ml NN cord-010119-t1x9gknd 11619 39 ) ) -RRB- cord-010119-t1x9gknd 11619 40 addressed address VBD cord-010119-t1x9gknd 11619 41 toxicology toxicology NN cord-010119-t1x9gknd 11619 42 concerns concern NNS cord-010119-t1x9gknd 11619 43 . . . cord-010119-t1x9gknd 11620 1 Nursing nursing NN cord-010119-t1x9gknd 11620 2 / / SYM cord-010119-t1x9gknd 11620 3 IT it PRP cord-010119-t1x9gknd 11620 4 allayed allay VBD cord-010119-t1x9gknd 11620 5 concern concern NN cord-010119-t1x9gknd 11620 6 over over IN cord-010119-t1x9gknd 11620 7 scanning scanning NN cord-010119-t1x9gknd 11620 8 issues issue NNS cord-010119-t1x9gknd 11620 9 with with IN cord-010119-t1x9gknd 11620 10 a a DT cord-010119-t1x9gknd 11620 11 simple simple JJ cord-010119-t1x9gknd 11620 12 demonstration demonstration NN cord-010119-t1x9gknd 11620 13 . . . cord-010119-t1x9gknd 11621 1 Finally finally RB cord-010119-t1x9gknd 11621 2 , , , cord-010119-t1x9gknd 11621 3 we -PRON- PRP cord-010119-t1x9gknd 11621 4 ensured ensure VBD cord-010119-t1x9gknd 11621 5 that that IN cord-010119-t1x9gknd 11621 6 all all DT cord-010119-t1x9gknd 11621 7 parties party NNS cord-010119-t1x9gknd 11621 8 were be VBD cord-010119-t1x9gknd 11621 9 aware aware JJ cord-010119-t1x9gknd 11621 10 that that IN cord-010119-t1x9gknd 11621 11 FDA FDA NNP cord-010119-t1x9gknd 11621 12 did do VBD cord-010119-t1x9gknd 11621 13 not not RB cord-010119-t1x9gknd 11621 14 require require VB cord-010119-t1x9gknd 11621 15 irradiation irradiation NN cord-010119-t1x9gknd 11621 16 of of IN cord-010119-t1x9gknd 11621 17 PR PR NNP cord-010119-t1x9gknd 11621 18 - - HYPH cord-010119-t1x9gknd 11621 19 SDP SDP NNP cord-010119-t1x9gknd 11621 20 . . . cord-010119-t1x9gknd 11622 1 Presentations presentation NNS cord-010119-t1x9gknd 11622 2 at at IN cord-010119-t1x9gknd 11622 3 the the DT cord-010119-t1x9gknd 11622 4 medical medical JJ cord-010119-t1x9gknd 11622 5 conferences conference NNS cord-010119-t1x9gknd 11622 6 were be VBD cord-010119-t1x9gknd 11622 7 also also RB cord-010119-t1x9gknd 11622 8 used use VBN cord-010119-t1x9gknd 11622 9 as as IN cord-010119-t1x9gknd 11622 10 an an DT cord-010119-t1x9gknd 11622 11 opportunity opportunity NN cord-010119-t1x9gknd 11622 12 to to TO cord-010119-t1x9gknd 11622 13 provide provide VB cord-010119-t1x9gknd 11622 14 transfusion transfusion NN cord-010119-t1x9gknd 11622 15 - - HYPH cord-010119-t1x9gknd 11622 16 transmitted transmit VBN cord-010119-t1x9gknd 11622 17 disease disease NN cord-010119-t1x9gknd 11622 18 training training NN cord-010119-t1x9gknd 11622 19 and and CC cord-010119-t1x9gknd 11622 20 information information NN cord-010119-t1x9gknd 11622 21 on on IN cord-010119-t1x9gknd 11622 22 platelet platelet NN cord-010119-t1x9gknd 11622 23 utilization utilization NN cord-010119-t1x9gknd 11622 24 . . . cord-010119-t1x9gknd 11623 1 Company company NN cord-010119-t1x9gknd 11623 2 personnel personnel NNS cord-010119-t1x9gknd 11623 3 did do VBD cord-010119-t1x9gknd 11623 4 not not RB cord-010119-t1x9gknd 11623 5 present present VB cord-010119-t1x9gknd 11623 6 at at IN cord-010119-t1x9gknd 11623 7 medical medical JJ cord-010119-t1x9gknd 11623 8 or or CC cord-010119-t1x9gknd 11623 9 nursing nursing NN cord-010119-t1x9gknd 11623 10 conferences conference NNS cord-010119-t1x9gknd 11623 11 per per IN cord-010119-t1x9gknd 11623 12 institutional institutional JJ cord-010119-t1x9gknd 11623 13 policy policy NN cord-010119-t1x9gknd 11623 14 . . . cord-010119-t1x9gknd 11624 1 No no DT cord-010119-t1x9gknd 11624 2 Background Background NNP cord-010119-t1x9gknd 11624 3 / / SYM cord-010119-t1x9gknd 11624 4 Case Case NNP cord-010119-t1x9gknd 11624 5 Studies Studies NNPS cord-010119-t1x9gknd 11624 6 : : : cord-010119-t1x9gknd 11624 7 Ensuring ensure VBG cord-010119-t1x9gknd 11624 8 platelet platelet NN cord-010119-t1x9gknd 11624 9 supply supply NN cord-010119-t1x9gknd 11624 10 capability capability NN cord-010119-t1x9gknd 11624 11 represents represent VBZ cord-010119-t1x9gknd 11624 12 a a DT cord-010119-t1x9gknd 11624 13 challenge challenge NN cord-010119-t1x9gknd 11624 14 in in IN cord-010119-t1x9gknd 11624 15 terms term NNS cord-010119-t1x9gknd 11624 16 of of IN cord-010119-t1x9gknd 11624 17 donor donor NN cord-010119-t1x9gknd 11624 18 recruitment recruitment NN cord-010119-t1x9gknd 11624 19 and and CC cord-010119-t1x9gknd 11624 20 inventory inventory NN cord-010119-t1x9gknd 11624 21 management management NN cord-010119-t1x9gknd 11624 22 operations operation NNS cord-010119-t1x9gknd 11624 23 . . . cord-010119-t1x9gknd 11625 1 In in IN cord-010119-t1x9gknd 11625 2 September September NNP cord-010119-t1x9gknd 11625 3 2017 2017 CD cord-010119-t1x9gknd 11625 4 , , , cord-010119-t1x9gknd 11625 5 the the DT cord-010119-t1x9gknd 11625 6 apheresis apheresis NN cord-010119-t1x9gknd 11625 7 collection collection NN cord-010119-t1x9gknd 11625 8 process process NN cord-010119-t1x9gknd 11625 9 ( ( -LRB- cord-010119-t1x9gknd 11625 10 ACP ACP NNP cord-010119-t1x9gknd 11625 11 ) ) -RRB- cord-010119-t1x9gknd 11625 12 was be VBD cord-010119-t1x9gknd 11625 13 completely completely RB cord-010119-t1x9gknd 11625 14 revised revise VBN cord-010119-t1x9gknd 11625 15 to to TO cord-010119-t1x9gknd 11625 16 increase increase VB cord-010119-t1x9gknd 11625 17 the the DT cord-010119-t1x9gknd 11625 18 number number NN cord-010119-t1x9gknd 11625 19 of of IN cord-010119-t1x9gknd 11625 20 products product NNS cord-010119-t1x9gknd 11625 21 per per IN cord-010119-t1x9gknd 11625 22 donation donation NN cord-010119-t1x9gknd 11625 23 by by IN cord-010119-t1x9gknd 11625 24 maximizing maximize VBG cord-010119-t1x9gknd 11625 25 the the DT cord-010119-t1x9gknd 11625 26 rate rate NN cord-010119-t1x9gknd 11625 27 of of IN cord-010119-t1x9gknd 11625 28 double double JJ cord-010119-t1x9gknd 11625 29 - - HYPH cord-010119-t1x9gknd 11625 30 platelet platelet NN cord-010119-t1x9gknd 11625 31 donations donation NNS cord-010119-t1x9gknd 11625 32 ( ( -LRB- cord-010119-t1x9gknd 11625 33 DPD DPD NNP cord-010119-t1x9gknd 11625 34 ) ) -RRB- cord-010119-t1x9gknd 11625 35 . . . cord-010119-t1x9gknd 11626 1 The the DT cord-010119-t1x9gknd 11626 2 process process NN cord-010119-t1x9gknd 11626 3 review review NN cord-010119-t1x9gknd 11626 4 has have VBZ cord-010119-t1x9gknd 11626 5 led lead VBN cord-010119-t1x9gknd 11626 6 to to IN cord-010119-t1x9gknd 11626 7 several several JJ cord-010119-t1x9gknd 11626 8 changes change NNS cord-010119-t1x9gknd 11626 9 , , , cord-010119-t1x9gknd 11626 10 including include VBG cord-010119-t1x9gknd 11626 11 the the DT cord-010119-t1x9gknd 11626 12 substitution substitution NN cord-010119-t1x9gknd 11626 13 of of IN cord-010119-t1x9gknd 11626 14 the the DT cord-010119-t1x9gknd 11626 15 pre pre JJ cord-010119-t1x9gknd 11626 16 - - JJ cord-010119-t1x9gknd 11626 17 donation donation NN cord-010119-t1x9gknd 11626 18 platelet platelet NN cord-010119-t1x9gknd 11626 19 ( ( -LRB- cord-010119-t1x9gknd 11626 20 PLT PLT NNP cord-010119-t1x9gknd 11626 21 ) ) -RRB- cord-010119-t1x9gknd 11626 22 count count VB cord-010119-t1x9gknd 11626 23 measurement measurement NN cord-010119-t1x9gknd 11626 24 before before IN cord-010119-t1x9gknd 11626 25 donation donation NN cord-010119-t1x9gknd 11626 26 type type NN cord-010119-t1x9gknd 11626 27 allocation allocation NN cord-010119-t1x9gknd 11626 28 , , , cord-010119-t1x9gknd 11626 29 in in IN cord-010119-t1x9gknd 11626 30 favor favor NN cord-010119-t1x9gknd 11626 31 of of IN cord-010119-t1x9gknd 11626 32 the the DT cord-010119-t1x9gknd 11626 33 use use NN cord-010119-t1x9gknd 11626 34 of of IN cord-010119-t1x9gknd 11626 35 the the DT cord-010119-t1x9gknd 11626 36 donor donor NN cord-010119-t1x9gknd 11626 37 's 's POS cord-010119-t1x9gknd 11626 38 past past JJ cord-010119-t1x9gknd 11626 39 donation donation NN cord-010119-t1x9gknd 11626 40 records record NNS cord-010119-t1x9gknd 11626 41 . . . cord-010119-t1x9gknd 11627 1 Multiple multiple JJ cord-010119-t1x9gknd 11627 2 processing processing NN cord-010119-t1x9gknd 11627 3 steps step NNS cord-010119-t1x9gknd 11627 4 were be VBD cord-010119-t1x9gknd 11627 5 eliminated eliminate VBN cord-010119-t1x9gknd 11627 6 , , , cord-010119-t1x9gknd 11627 7 and and CC cord-010119-t1x9gknd 11627 8 the the DT cord-010119-t1x9gknd 11627 9 evaluation evaluation NN cord-010119-t1x9gknd 11627 10 of of IN cord-010119-t1x9gknd 11627 11 PLT PLT NNP cord-010119-t1x9gknd 11627 12 concentration concentration NN cord-010119-t1x9gknd 11627 13 as as IN cord-010119-t1x9gknd 11627 14 a a DT cord-010119-t1x9gknd 11627 15 function function NN cord-010119-t1x9gknd 11627 16 of of IN cord-010119-t1x9gknd 11627 17 time time NN cord-010119-t1x9gknd 11627 18 , , , cord-010119-t1x9gknd 11627 19 deduced deduce VBN cord-010119-t1x9gknd 11627 20 from from IN cord-010119-t1x9gknd 11627 21 complete complete JJ cord-010119-t1x9gknd 11627 22 blood blood NN cord-010119-t1x9gknd 11627 23 count count NN cord-010119-t1x9gknd 11627 24 ( ( -LRB- cord-010119-t1x9gknd 11627 25 CBC CBC NNP cord-010119-t1x9gknd 11627 26 ) ) -RRB- cord-010119-t1x9gknd 11627 27 measurements measurement NNS cord-010119-t1x9gknd 11627 28 , , , cord-010119-t1x9gknd 11627 29 allowed allow VBD cord-010119-t1x9gknd 11627 30 the the DT cord-010119-t1x9gknd 11627 31 centralization centralization NN cord-010119-t1x9gknd 11627 32 of of IN cord-010119-t1x9gknd 11627 33 the the DT cord-010119-t1x9gknd 11627 34 analysis analysis NN cord-010119-t1x9gknd 11627 35 at at IN cord-010119-t1x9gknd 11627 36 the the DT cord-010119-t1x9gknd 11627 37 QC QC NNP cord-010119-t1x9gknd 11627 38 Department Department NNP cord-010119-t1x9gknd 11627 39 . . . cord-010119-t1x9gknd 11628 1 Finally finally RB cord-010119-t1x9gknd 11628 2 , , , cord-010119-t1x9gknd 11628 3 introducing introduce VBG cord-010119-t1x9gknd 11628 4 the the DT cord-010119-t1x9gknd 11628 5 concept concept NN cord-010119-t1x9gknd 11628 6 of of IN cord-010119-t1x9gknd 11628 7 non non JJ cord-010119-t1x9gknd 11628 8 - - JJ cord-010119-t1x9gknd 11628 9 optimal optimal JJ cord-010119-t1x9gknd 11628 10 donations donation NNS cord-010119-t1x9gknd 11628 11 has have VBZ cord-010119-t1x9gknd 11628 12 led lead VBN cord-010119-t1x9gknd 11628 13 to to IN cord-010119-t1x9gknd 11628 14 an an DT cord-010119-t1x9gknd 11628 15 increase increase NN cord-010119-t1x9gknd 11628 16 in in IN cord-010119-t1x9gknd 11628 17 the the DT cord-010119-t1x9gknd 11628 18 proportion proportion NN cord-010119-t1x9gknd 11628 19 of of IN cord-010119-t1x9gknd 11628 20 DPD DPD NNP cord-010119-t1x9gknd 11628 21 . . . cord-010119-t1x9gknd 11629 1 Study Study NNP cord-010119-t1x9gknd 11629 2 Design Design NNP cord-010119-t1x9gknd 11629 3 / / SYM cord-010119-t1x9gknd 11629 4 Method method NN cord-010119-t1x9gknd 11629 5 : : : cord-010119-t1x9gknd 11630 1 At at IN cord-010119-t1x9gknd 11630 2 the the DT cord-010119-t1x9gknd 11630 3 donation donation NN cord-010119-t1x9gknd 11630 4 centers center NNS cord-010119-t1x9gknd 11630 5 , , , cord-010119-t1x9gknd 11630 6 whole whole JJ cord-010119-t1x9gknd 11630 7 blood blood NN cord-010119-t1x9gknd 11630 8 ( ( -LRB- cord-010119-t1x9gknd 11630 9 WB WB NNP cord-010119-t1x9gknd 11630 10 ) ) -RRB- cord-010119-t1x9gknd 11630 11 from from IN cord-010119-t1x9gknd 11630 12 10 10 CD cord-010119-t1x9gknd 11630 13 donors donor NNS cord-010119-t1x9gknd 11630 14 was be VBD cord-010119-t1x9gknd 11630 15 collected collect VBN cord-010119-t1x9gknd 11630 16 in in IN cord-010119-t1x9gknd 11630 17 K K NNP cord-010119-t1x9gknd 11630 18 3 3 CD cord-010119-t1x9gknd 11630 19 EDTA EDTA NNP cord-010119-t1x9gknd 11630 20 tubes tube NNS cord-010119-t1x9gknd 11630 21 . . . cord-010119-t1x9gknd 11631 1 PLT PLT NNP cord-010119-t1x9gknd 11631 2 concentrations concentration NNS cord-010119-t1x9gknd 11631 3 were be VBD cord-010119-t1x9gknd 11631 4 determined determine VBN cord-010119-t1x9gknd 11631 5 at at IN cord-010119-t1x9gknd 11631 6 the the DT cord-010119-t1x9gknd 11631 7 QC QC NNP cord-010119-t1x9gknd 11631 8 Department Department NNP cord-010119-t1x9gknd 11631 9 using use VBG cord-010119-t1x9gknd 11631 10 the the DT cord-010119-t1x9gknd 11631 11 Coulter Coulter NNP cord-010119-t1x9gknd 11631 12 AcT act NN cord-010119-t1x9gknd 11631 13 5 5 CD cord-010119-t1x9gknd 11631 14 diff diff NN cord-010119-t1x9gknd 11631 15 hematology hematology NN cord-010119-t1x9gknd 11631 16 analyzer analyzer NN cord-010119-t1x9gknd 11631 17 ( ( -LRB- cord-010119-t1x9gknd 11631 18 Beckman Beckman NNP cord-010119-t1x9gknd 11631 19 Coulter Coulter NNP cord-010119-t1x9gknd 11631 20 ) ) -RRB- cord-010119-t1x9gknd 11631 21 . . . cord-010119-t1x9gknd 11632 1 Sample sample NN cord-010119-t1x9gknd 11632 2 tubes tube NNS cord-010119-t1x9gknd 11632 3 were be VBD cord-010119-t1x9gknd 11632 4 stored store VBN cord-010119-t1x9gknd 11632 5 at at IN cord-010119-t1x9gknd 11632 6 20 20 CD cord-010119-t1x9gknd 11632 7 - - SYM cord-010119-t1x9gknd 11632 8 248C 248c CD cord-010119-t1x9gknd 11632 9 and and CC cord-010119-t1x9gknd 11632 10 measured measure VBN cord-010119-t1x9gknd 11632 11 at at IN cord-010119-t1x9gknd 11632 12 24 24 CD cord-010119-t1x9gknd 11632 13 , , , cord-010119-t1x9gknd 11632 14 48 48 CD cord-010119-t1x9gknd 11632 15 and and CC cord-010119-t1x9gknd 11632 16 72 72 CD cord-010119-t1x9gknd 11632 17 hours hour NNS cord-010119-t1x9gknd 11632 18 post post NN cord-010119-t1x9gknd 11632 19 - - NN cord-010119-t1x9gknd 11632 20 collection collection NN cord-010119-t1x9gknd 11632 21 . . . cord-010119-t1x9gknd 11633 1 Single single JJ cord-010119-t1x9gknd 11633 2 platelet platelet NN cord-010119-t1x9gknd 11633 3 donations donation NNS cord-010119-t1x9gknd 11633 4 ( ( -LRB- cord-010119-t1x9gknd 11633 5 SPD SPD NNP cord-010119-t1x9gknd 11633 6 ) ) -RRB- cord-010119-t1x9gknd 11633 7 or or CC cord-010119-t1x9gknd 11633 8 DPD DPD NNP cord-010119-t1x9gknd 11633 9 were be VBD cord-010119-t1x9gknd 11633 10 collected collect VBN cord-010119-t1x9gknd 11633 11 using use VBG cord-010119-t1x9gknd 11633 12 the the DT cord-010119-t1x9gknd 11633 13 Trima Trima NNP cord-010119-t1x9gknd 11633 14 Accel Accel NNP cord-010119-t1x9gknd 11633 15 . . . cord-010119-t1x9gknd 11634 1 Units unit NNS cord-010119-t1x9gknd 11634 2 were be VBD cord-010119-t1x9gknd 11634 3 pooled pool VBN cord-010119-t1x9gknd 11634 4 and and CC cord-010119-t1x9gknd 11634 5 split split VBN cord-010119-t1x9gknd 11634 6 in in IN cord-010119-t1x9gknd 11634 7 ELP ELP NNP cord-010119-t1x9gknd 11634 8 ( ( -LRB- cord-010119-t1x9gknd 11634 9 Extended Extended NNP cord-010119-t1x9gknd 11634 10 Life Life NNP cord-010119-t1x9gknd 11634 11 Platelet platelet NN cord-010119-t1x9gknd 11634 12 , , , cord-010119-t1x9gknd 11634 13 Terumo Terumo NNP cord-010119-t1x9gknd 11634 14 BCT BCT NNP cord-010119-t1x9gknd 11634 15 ) ) -RRB- cord-010119-t1x9gknd 11634 16 storage storage NN cord-010119-t1x9gknd 11634 17 bags bag NNS cord-010119-t1x9gknd 11634 18 to to TO cord-010119-t1x9gknd 11634 19 mimic mimic VB cord-010119-t1x9gknd 11634 20 SPD SPD NNP cord-010119-t1x9gknd 11634 21 ( ( -LRB- cord-010119-t1x9gknd 11634 22 250 250 CD cord-010119-t1x9gknd 11634 23 mL ml NN cord-010119-t1x9gknd 11634 24 ; ; : cord-010119-t1x9gknd 11634 25 n58 n58 CD cord-010119-t1x9gknd 11634 26 ) ) -RRB- cord-010119-t1x9gknd 11634 27 or or CC cord-010119-t1x9gknd 11634 28 DPD DPD NNP cord-010119-t1x9gknd 11634 29 units unit NNS cord-010119-t1x9gknd 11634 30 ( ( -LRB- cord-010119-t1x9gknd 11634 31 500 500 CD cord-010119-t1x9gknd 11634 32 mL ml NN cord-010119-t1x9gknd 11634 33 ; ; : cord-010119-t1x9gknd 11634 34 n54 n54 CD cord-010119-t1x9gknd 11634 35 ) ) -RRB- cord-010119-t1x9gknd 11634 36 . . . cord-010119-t1x9gknd 11635 1 PLT PLT NNP cord-010119-t1x9gknd 11635 2 pools pool NNS cord-010119-t1x9gknd 11635 3 were be VBD cord-010119-t1x9gknd 11635 4 stored store VBN cord-010119-t1x9gknd 11635 5 at at IN cord-010119-t1x9gknd 11635 6 20 20 CD cord-010119-t1x9gknd 11635 7 - - SYM cord-010119-t1x9gknd 11635 8 248C 248c CD cord-010119-t1x9gknd 11635 9 under under IN cord-010119-t1x9gknd 11635 10 mild mild JJ cord-010119-t1x9gknd 11635 11 agitation agitation NN cord-010119-t1x9gknd 11635 12 for for IN cord-010119-t1x9gknd 11635 13 seven seven CD cord-010119-t1x9gknd 11635 14 days day NNS cord-010119-t1x9gknd 11635 15 except except IN cord-010119-t1x9gknd 11635 16 for for IN cord-010119-t1x9gknd 11635 17 DPD DPD NNP cord-010119-t1x9gknd 11635 18 , , , cord-010119-t1x9gknd 11635 19 which which WDT cord-010119-t1x9gknd 11635 20 were be VBD cord-010119-t1x9gknd 11635 21 split split VBN cord-010119-t1x9gknd 11635 22 in in IN cord-010119-t1x9gknd 11635 23 two two CD cord-010119-t1x9gknd 11635 24 250-mL 250-ml CD cord-010119-t1x9gknd 11635 25 bags bag NNS cord-010119-t1x9gknd 11635 26 after after IN cord-010119-t1x9gknd 11635 27 18 18 CD cord-010119-t1x9gknd 11635 28 6 6 CD cord-010119-t1x9gknd 11635 29 1 1 CD cord-010119-t1x9gknd 11635 30 h. h. NN cord-010119-t1x9gknd 11635 31 Samples sample NNS cord-010119-t1x9gknd 11635 32 were be VBD cord-010119-t1x9gknd 11635 33 taken take VBN cord-010119-t1x9gknd 11635 34 on on IN cord-010119-t1x9gknd 11635 35 days day NNS cord-010119-t1x9gknd 11635 36 1 1 CD cord-010119-t1x9gknd 11635 37 and and CC cord-010119-t1x9gknd 11635 38 7 7 CD cord-010119-t1x9gknd 11635 39 . . . cord-010119-t1x9gknd 11636 1 pH pH NNP cord-010119-t1x9gknd 11636 2 , , , cord-010119-t1x9gknd 11636 3 pO pO NNP cord-010119-t1x9gknd 11636 4 2 2 CD cord-010119-t1x9gknd 11636 5 and and CC cord-010119-t1x9gknd 11636 6 pCO pco CD cord-010119-t1x9gknd 11636 7 2 2 CD cord-010119-t1x9gknd 11636 8 , , , cord-010119-t1x9gknd 11636 9 hypotonic hypotonic JJ cord-010119-t1x9gknd 11636 10 shock shock NN cord-010119-t1x9gknd 11636 11 response response NN cord-010119-t1x9gknd 11636 12 ( ( -LRB- cord-010119-t1x9gknd 11636 13 HSR HSR NNP cord-010119-t1x9gknd 11636 14 ) ) -RRB- cord-010119-t1x9gknd 11636 15 , , , cord-010119-t1x9gknd 11636 16 extent extent NN cord-010119-t1x9gknd 11636 17 of of IN cord-010119-t1x9gknd 11636 18 shape shape NN cord-010119-t1x9gknd 11636 19 change change NN cord-010119-t1x9gknd 11636 20 ( ( -LRB- cord-010119-t1x9gknd 11636 21 ESC ESC NNP cord-010119-t1x9gknd 11636 22 ) ) -RRB- cord-010119-t1x9gknd 11636 23 , , , cord-010119-t1x9gknd 11636 24 CD62p CD62p NNP cord-010119-t1x9gknd 11636 25 expression expression NN cord-010119-t1x9gknd 11636 26 , , , cord-010119-t1x9gknd 11636 27 ATP ATP NNP cord-010119-t1x9gknd 11636 28 content content NN cord-010119-t1x9gknd 11636 29 , , , cord-010119-t1x9gknd 11636 30 lactate lactate NN cord-010119-t1x9gknd 11636 31 and and CC cord-010119-t1x9gknd 11636 32 glucose glucose NN cord-010119-t1x9gknd 11636 33 concentrations concentration NNS cord-010119-t1x9gknd 11636 34 were be VBD cord-010119-t1x9gknd 11636 35 used use VBN cord-010119-t1x9gknd 11636 36 as as IN cord-010119-t1x9gknd 11636 37 in in IN cord-010119-t1x9gknd 11636 38 vitroquality vitroquality NN cord-010119-t1x9gknd 11636 39 markers marker NNS cord-010119-t1x9gknd 11636 40 . . . cord-010119-t1x9gknd 11637 1 Results result NNS cord-010119-t1x9gknd 11638 1 /Finding /finde VBG cord-010119-t1x9gknd 11638 2 : : : cord-010119-t1x9gknd 11639 1 PLT PLT NNP cord-010119-t1x9gknd 11639 2 concentration concentration NN cord-010119-t1x9gknd 11639 3 as as IN cord-010119-t1x9gknd 11639 4 a a DT cord-010119-t1x9gknd 11639 5 function function NN cord-010119-t1x9gknd 11639 6 of of IN cord-010119-t1x9gknd 11639 7 time time NN cord-010119-t1x9gknd 11639 8 , , , cord-010119-t1x9gknd 11639 9 determined determine VBN cord-010119-t1x9gknd 11639 10 from from IN cord-010119-t1x9gknd 11639 11 WB WB NNP cord-010119-t1x9gknd 11639 12 CBC CBC NNP cord-010119-t1x9gknd 11639 13 measurements measurement NNS cord-010119-t1x9gknd 11639 14 , , , cord-010119-t1x9gknd 11639 15 showed show VBD cord-010119-t1x9gknd 11639 16 no no DT cord-010119-t1x9gknd 11639 17 significant significant JJ cord-010119-t1x9gknd 11639 18 difference difference NN cord-010119-t1x9gknd 11639 19 at at IN cord-010119-t1x9gknd 11639 20 24h 24h NNS cord-010119-t1x9gknd 11639 21 ( ( -LRB- cord-010119-t1x9gknd 11639 22 247 247 CD cord-010119-t1x9gknd 11639 23 6 6 CD cord-010119-t1x9gknd 11639 24 32 32 CD cord-010119-t1x9gknd 11639 25 PLTx10 PLTx10 NNP cord-010119-t1x9gknd 11639 26 9 9 CD cord-010119-t1x9gknd 11639 27 /L /L . cord-010119-t1x9gknd 11639 28 ) ) -RRB- cord-010119-t1x9gknd 11639 29 , , , cord-010119-t1x9gknd 11639 30 48h 48h NNS cord-010119-t1x9gknd 11639 31 ( ( -LRB- cord-010119-t1x9gknd 11639 32 247 247 CD cord-010119-t1x9gknd 11639 33 6 6 CD cord-010119-t1x9gknd 11639 34 27 27 CD cord-010119-t1x9gknd 11639 35 PLTx10 PLTx10 NNP cord-010119-t1x9gknd 11639 36 9 9 CD cord-010119-t1x9gknd 11639 37 /L /L , cord-010119-t1x9gknd 11639 38 ) ) -RRB- cord-010119-t1x9gknd 11639 39 and and CC cord-010119-t1x9gknd 11639 40 72h 72h NNS cord-010119-t1x9gknd 11639 41 ( ( -LRB- cord-010119-t1x9gknd 11640 1 247 247 CD cord-010119-t1x9gknd 11640 2 6 6 CD cord-010119-t1x9gknd 11640 3 32 32 CD cord-010119-t1x9gknd 11640 4 PLTx10 PLTx10 NNP cord-010119-t1x9gknd 11640 5 9 9 CD cord-010119-t1x9gknd 11640 6 /L /L . cord-010119-t1x9gknd 11640 7 ) ) -RRB- cord-010119-t1x9gknd 11640 8 postdonation postdonation NN cord-010119-t1x9gknd 11640 9 . . . cord-010119-t1x9gknd 11641 1 DPD DPD NNP cord-010119-t1x9gknd 11641 2 can can MD cord-010119-t1x9gknd 11641 3 be be VB cord-010119-t1x9gknd 11641 4 stored store VBN cord-010119-t1x9gknd 11641 5 in in IN cord-010119-t1x9gknd 11641 6 the the DT cord-010119-t1x9gknd 11641 7 same same JJ cord-010119-t1x9gknd 11641 8 collection collection NN cord-010119-t1x9gknd 11641 9 bag bag NN cord-010119-t1x9gknd 11641 10 for for IN cord-010119-t1x9gknd 11641 11 24h 24h NNS cord-010119-t1x9gknd 11641 12 after after IN cord-010119-t1x9gknd 11641 13 donation donation NN cord-010119-t1x9gknd 11641 14 without without IN cord-010119-t1x9gknd 11641 15 any any DT cord-010119-t1x9gknd 11641 16 significant significant JJ cord-010119-t1x9gknd 11641 17 impact impact NN cord-010119-t1x9gknd 11641 18 on on IN cord-010119-t1x9gknd 11641 19 PLT PLT NNP cord-010119-t1x9gknd 11641 20 quality quality NN cord-010119-t1x9gknd 11641 21 markers marker NNS cord-010119-t1x9gknd 11641 22 . . . cord-010119-t1x9gknd 11642 1 PLT PLT NNP cord-010119-t1x9gknd 11642 2 concentrations concentration NNS cord-010119-t1x9gknd 11642 3 were be VBD cord-010119-t1x9gknd 11642 4 within within IN cord-010119-t1x9gknd 11642 5 the the DT cord-010119-t1x9gknd 11642 6 manufacturer manufacturer NN cord-010119-t1x9gknd 11642 7 's 's POS cord-010119-t1x9gknd 11642 8 acceptable acceptable JJ cord-010119-t1x9gknd 11642 9 limits limit NNS cord-010119-t1x9gknd 11642 10 ( ( -LRB- cord-010119-t1x9gknd 11642 11 1141 1141 CD cord-010119-t1x9gknd 11642 12 - - SYM cord-010119-t1x9gknd 11642 13 1526 1526 CD cord-010119-t1x9gknd 11642 14 PLTx10 PLTx10 NNP cord-010119-t1x9gknd 11642 15 9 9 CD cord-010119-t1x9gknd 11642 16 / / SYM cord-010119-t1x9gknd 11642 17 L L NNP cord-010119-t1x9gknd 11642 18 ) ) -RRB- cord-010119-t1x9gknd 11642 19 before before IN cord-010119-t1x9gknd 11642 20 splitting splitting NN cord-010119-t1x9gknd 11642 21 . . . cord-010119-t1x9gknd 11643 1 On on IN cord-010119-t1x9gknd 11643 2 day day NN cord-010119-t1x9gknd 11643 3 1 1 CD cord-010119-t1x9gknd 11643 4 , , , cord-010119-t1x9gknd 11643 5 lactate lactate NN cord-010119-t1x9gknd 11643 6 and and CC cord-010119-t1x9gknd 11643 7 pCO pco CD cord-010119-t1x9gknd 11643 8 2 2 CD cord-010119-t1x9gknd 11643 9 concentrations concentration NNS cord-010119-t1x9gknd 11643 10 increased increase VBD cord-010119-t1x9gknd 11643 11 , , , cord-010119-t1x9gknd 11643 12 and and CC cord-010119-t1x9gknd 11643 13 pO po NN cord-010119-t1x9gknd 11643 14 2 2 CD cord-010119-t1x9gknd 11643 15 decreased decrease VBD cord-010119-t1x9gknd 11643 16 in in IN cord-010119-t1x9gknd 11643 17 DPD DPD NNP cord-010119-t1x9gknd 11643 18 . . . cord-010119-t1x9gknd 11644 1 However however RB cord-010119-t1x9gknd 11644 2 , , , cord-010119-t1x9gknd 11644 3 these these DT cord-010119-t1x9gknd 11644 4 values value NNS cord-010119-t1x9gknd 11644 5 normalize normalize VBP cord-010119-t1x9gknd 11644 6 to to IN cord-010119-t1x9gknd 11644 7 those those DT cord-010119-t1x9gknd 11644 8 of of IN cord-010119-t1x9gknd 11644 9 control control NN cord-010119-t1x9gknd 11644 10 units unit NNS cord-010119-t1x9gknd 11644 11 at at IN cord-010119-t1x9gknd 11644 12 the the DT cord-010119-t1x9gknd 11644 13 expiration expiration NN cord-010119-t1x9gknd 11644 14 day day NN cord-010119-t1x9gknd 11644 15 . . . cord-010119-t1x9gknd 11645 1 Conclusion conclusion NN cord-010119-t1x9gknd 11645 2 : : : cord-010119-t1x9gknd 11646 1 This this DT cord-010119-t1x9gknd 11646 2 project project NN cord-010119-t1x9gknd 11646 3 was be VBD cord-010119-t1x9gknd 11646 4 approved approve VBN cord-010119-t1x9gknd 11646 5 by by IN cord-010119-t1x9gknd 11646 6 Health Health NNP cord-010119-t1x9gknd 11646 7 Canada Canada NNP cord-010119-t1x9gknd 11646 8 and and CC cord-010119-t1x9gknd 11646 9 implemented implement VBD cord-010119-t1x9gknd 11646 10 in in IN cord-010119-t1x9gknd 11646 11 our -PRON- PRP$ cord-010119-t1x9gknd 11646 12 organization organization NN cord-010119-t1x9gknd 11646 13 in in IN cord-010119-t1x9gknd 11646 14 March March NNP cord-010119-t1x9gknd 11646 15 2017 2017 CD cord-010119-t1x9gknd 11646 16 . . . cord-010119-t1x9gknd 11647 1 There there EX cord-010119-t1x9gknd 11647 2 are be VBP cord-010119-t1x9gknd 11647 3 numerous numerous JJ cord-010119-t1x9gknd 11647 4 operational operational JJ cord-010119-t1x9gknd 11647 5 and and CC cord-010119-t1x9gknd 11647 6 cost cost NN cord-010119-t1x9gknd 11647 7 benefits benefit NNS cord-010119-t1x9gknd 11647 8 from from IN cord-010119-t1x9gknd 11647 9 this this DT cord-010119-t1x9gknd 11647 10 process process NN cord-010119-t1x9gknd 11647 11 optimization optimization NN cord-010119-t1x9gknd 11647 12 initiative initiative NN cord-010119-t1x9gknd 11647 13 , , , cord-010119-t1x9gknd 11647 14 without without IN cord-010119-t1x9gknd 11647 15 significant significant JJ cord-010119-t1x9gknd 11647 16 impact impact NN cord-010119-t1x9gknd 11647 17 on on IN cord-010119-t1x9gknd 11647 18 safety safety NN cord-010119-t1x9gknd 11647 19 and and CC cord-010119-t1x9gknd 11647 20 quality quality NN cord-010119-t1x9gknd 11647 21 . . . cord-010119-t1x9gknd 11648 1 Post post JJ cord-010119-t1x9gknd 11648 2 - - JJ cord-010119-t1x9gknd 11648 3 implantation implantation JJ cord-010119-t1x9gknd 11648 4 efficiency efficiency NN cord-010119-t1x9gknd 11648 5 data datum NNS cord-010119-t1x9gknd 11648 6 will will MD cord-010119-t1x9gknd 11648 7 be be VB cord-010119-t1x9gknd 11648 8 compared compare VBN cord-010119-t1x9gknd 11648 9 to to IN cord-010119-t1x9gknd 11648 10 the the DT cord-010119-t1x9gknd 11648 11 targeted target VBN cord-010119-t1x9gknd 11648 12 12 12 CD cord-010119-t1x9gknd 11648 13 % % NN cord-010119-t1x9gknd 11648 14 increase increase NN cord-010119-t1x9gknd 11648 15 in in IN cord-010119-t1x9gknd 11648 16 the the DT cord-010119-t1x9gknd 11648 17 targeted target VBN cord-010119-t1x9gknd 11648 18 number number NN cord-010119-t1x9gknd 11648 19 of of IN cord-010119-t1x9gknd 11648 20 PLT PLT NNP cord-010119-t1x9gknd 11648 21 units unit NNS cord-010119-t1x9gknd 11648 22 per per IN cord-010119-t1x9gknd 11648 23 donation donation NN cord-010119-t1x9gknd 11648 24 ratio ratio NN cord-010119-t1x9gknd 11648 25 . . . cord-010119-t1x9gknd 11649 1 Phased phase VBN cord-010119-t1x9gknd 11649 2 Implementation Implementation NNP cord-010119-t1x9gknd 11649 3 of of IN cord-010119-t1x9gknd 11649 4 Pathogen Pathogen NNP cord-010119-t1x9gknd 11649 5 - - HYPH cord-010119-t1x9gknd 11649 6 Reduced reduce VBN cord-010119-t1x9gknd 11649 7 Platelets platelet NNS cord-010119-t1x9gknd 11649 8 in in IN cord-010119-t1x9gknd 11649 9 a a DT cord-010119-t1x9gknd 11649 10 Health Health NNP cord-010119-t1x9gknd 11649 11 System System NNP cord-010119-t1x9gknd 11649 12 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 11649 13 S. S. NNP cord-010119-t1x9gknd 11649 14 Allen Allen NNP cord-010119-t1x9gknd 11649 15 * * NFP cord-010119-t1x9gknd 11649 16 1 1 CD cord-010119-t1x9gknd 11649 17 , , , cord-010119-t1x9gknd 11649 18 Colleen Colleen NNP cord-010119-t1x9gknd 11649 19 Vincent Vincent NNP cord-010119-t1x9gknd 11649 20 2 2 CD cord-010119-t1x9gknd 11649 21 and and CC cord-010119-t1x9gknd 11649 22 Patricia Patricia NNP cord-010119-t1x9gknd 11649 23 Kopko Kopko NNP cord-010119-t1x9gknd 11649 24 1 1 CD cord-010119-t1x9gknd 11649 25 . . . cord-010119-t1x9gknd 11649 26 1 1 CD cord-010119-t1x9gknd 11649 27 University University NNP cord-010119-t1x9gknd 11649 28 of of IN cord-010119-t1x9gknd 11649 29 California California NNP cord-010119-t1x9gknd 11649 30 -San -San HYPH cord-010119-t1x9gknd 11649 31 Diego Diego NNP cord-010119-t1x9gknd 11649 32 , , , cord-010119-t1x9gknd 11649 33 2 2 CD cord-010119-t1x9gknd 11649 34 American American NNP cord-010119-t1x9gknd 11649 35 Red Red NNP cord-010119-t1x9gknd 11649 36 Cross Cross NNP cord-010119-t1x9gknd 11649 37 Background Background NNP cord-010119-t1x9gknd 11649 38 / / SYM cord-010119-t1x9gknd 11649 39 Case Case NNP cord-010119-t1x9gknd 11649 40 Studies Studies NNPS cord-010119-t1x9gknd 11649 41 : : : cord-010119-t1x9gknd 11650 1 Pathogen pathogen NN cord-010119-t1x9gknd 11650 2 reduced reduce VBN cord-010119-t1x9gknd 11650 3 platelets platelet NNS cord-010119-t1x9gknd 11650 4 ( ( -LRB- cord-010119-t1x9gknd 11650 5 PRP PRP NNP cord-010119-t1x9gknd 11650 6 ) ) -RRB- cord-010119-t1x9gknd 11650 7 provide provide VB cord-010119-t1x9gknd 11650 8 improved improved JJ cord-010119-t1x9gknd 11650 9 safety safety NN cord-010119-t1x9gknd 11650 10 compared compare VBN cord-010119-t1x9gknd 11650 11 to to IN cord-010119-t1x9gknd 11650 12 conventional conventional JJ cord-010119-t1x9gknd 11650 13 apheresis apheresis NN cord-010119-t1x9gknd 11650 14 platelets platelet NNS cord-010119-t1x9gknd 11650 15 , , , cord-010119-t1x9gknd 11650 16 but but CC cord-010119-t1x9gknd 11650 17 collection collection NN cord-010119-t1x9gknd 11650 18 and and CC cord-010119-t1x9gknd 11650 19 manufacturing manufacturing NN cord-010119-t1x9gknd 11650 20 are be VBP cord-010119-t1x9gknd 11650 21 complex complex JJ cord-010119-t1x9gknd 11650 22 . . . cord-010119-t1x9gknd 11651 1 Early early JJ cord-010119-t1x9gknd 11651 2 evidence evidence NN cord-010119-t1x9gknd 11651 3 shows show VBZ cord-010119-t1x9gknd 11651 4 only only RB cord-010119-t1x9gknd 11651 5 40 40 CD cord-010119-t1x9gknd 11651 6 - - SYM cord-010119-t1x9gknd 11651 7 45 45 CD cord-010119-t1x9gknd 11651 8 % % NN cord-010119-t1x9gknd 11651 9 of of IN cord-010119-t1x9gknd 11651 10 double double JJ cord-010119-t1x9gknd 11651 11 platelet platelet NN cord-010119-t1x9gknd 11651 12 collections collection NNS cord-010119-t1x9gknd 11651 13 meet meet VBP cord-010119-t1x9gknd 11651 14 requirements requirement NNS cord-010119-t1x9gknd 11651 15 for for IN cord-010119-t1x9gknd 11651 16 pathogen pathogen NN cord-010119-t1x9gknd 11651 17 reduction reduction NN cord-010119-t1x9gknd 11651 18 treatment treatment NN cord-010119-t1x9gknd 11651 19 . . . cord-010119-t1x9gknd 11652 1 1 1 LS cord-010119-t1x9gknd 11652 2 Blood blood NN cord-010119-t1x9gknd 11652 3 centers center NNS cord-010119-t1x9gknd 11652 4 need need VBP cord-010119-t1x9gknd 11652 5 hospitals hospital NNS cord-010119-t1x9gknd 11652 6 to to TO cord-010119-t1x9gknd 11652 7 implement implement VB cord-010119-t1x9gknd 11652 8 PRP PRP NNP cord-010119-t1x9gknd 11652 9 to to TO cord-010119-t1x9gknd 11652 10 start start VB cord-010119-t1x9gknd 11652 11 manufacturing manufacture VBG cord-010119-t1x9gknd 11652 12 , , , cord-010119-t1x9gknd 11652 13 but but CC cord-010119-t1x9gknd 11652 14 hospitals hospital NNS cord-010119-t1x9gknd 11652 15 may may MD cord-010119-t1x9gknd 11652 16 not not RB cord-010119-t1x9gknd 11652 17 wish wish VB cord-010119-t1x9gknd 11652 18 to to TO cord-010119-t1x9gknd 11652 19 use use VB cord-010119-t1x9gknd 11652 20 PRP PRP NNP cord-010119-t1x9gknd 11652 21 until until IN cord-010119-t1x9gknd 11652 22 they -PRON- PRP cord-010119-t1x9gknd 11652 23 can can MD cord-010119-t1x9gknd 11652 24 provide provide VB cord-010119-t1x9gknd 11652 25 the the DT cord-010119-t1x9gknd 11652 26 product product NN cord-010119-t1x9gknd 11652 27 to to IN cord-010119-t1x9gknd 11652 28 all all DT cord-010119-t1x9gknd 11652 29 patients patient NNS cord-010119-t1x9gknd 11652 30 . . . cord-010119-t1x9gknd 11653 1 Scaling scale VBG cord-010119-t1x9gknd 11653 2 up up RP cord-010119-t1x9gknd 11653 3 manufacturing manufacture VBG cord-010119-t1x9gknd 11653 4 at at IN cord-010119-t1x9gknd 11653 5 the the DT cord-010119-t1x9gknd 11653 6 blood blood NN cord-010119-t1x9gknd 11653 7 center center NN cord-010119-t1x9gknd 11653 8 and and CC cord-010119-t1x9gknd 11653 9 phasing phase VBG cord-010119-t1x9gknd 11653 10 in in IN cord-010119-t1x9gknd 11653 11 PRP PRP NNP cord-010119-t1x9gknd 11653 12 across across IN cord-010119-t1x9gknd 11653 13 patient patient JJ cord-010119-t1x9gknd 11653 14 populations population NNS cord-010119-t1x9gknd 11653 15 meets meet VBZ cord-010119-t1x9gknd 11653 16 both both DT cord-010119-t1x9gknd 11653 17 parties party NNS cord-010119-t1x9gknd 11653 18 ' ' POS cord-010119-t1x9gknd 11653 19 needs need NNS cord-010119-t1x9gknd 11653 20 . . . cord-010119-t1x9gknd 11654 1 We -PRON- PRP cord-010119-t1x9gknd 11654 2 evaluated evaluate VBD cord-010119-t1x9gknd 11654 3 this this DT cord-010119-t1x9gknd 11654 4 strategy strategy NN cord-010119-t1x9gknd 11654 5 at at IN cord-010119-t1x9gknd 11654 6 our -PRON- PRP$ cord-010119-t1x9gknd 11654 7 university university NN cord-010119-t1x9gknd 11654 8 health health NN cord-010119-t1x9gknd 11654 9 system system NN cord-010119-t1x9gknd 11654 10 ( ( -LRB- cord-010119-t1x9gknd 11654 11 transfusion transfusion NN cord-010119-t1x9gknd 11654 12 volume volume NN cord-010119-t1x9gknd 11654 13 : : : cord-010119-t1x9gknd 11654 14 9,500 9,500 CD cord-010119-t1x9gknd 11654 15 apheresis apheresis NN cord-010119-t1x9gknd 11654 16 platelets platelet NNS cord-010119-t1x9gknd 11654 17 annually annually RB cord-010119-t1x9gknd 11654 18 ) ) -RRB- cord-010119-t1x9gknd 11654 19 , , , cord-010119-t1x9gknd 11654 20 which which WDT cord-010119-t1x9gknd 11654 21 includes include VBZ cord-010119-t1x9gknd 11654 22 two two CD cord-010119-t1x9gknd 11654 23 hospitals hospital NNS cord-010119-t1x9gknd 11654 24 ( ( -LRB- cord-010119-t1x9gknd 11654 25 750 750 CD cord-010119-t1x9gknd 11654 26 inpatient inpatient JJ cord-010119-t1x9gknd 11654 27 beds bed NNS cord-010119-t1x9gknd 11654 28 ) ) -RRB- cord-010119-t1x9gknd 11654 29 and and CC cord-010119-t1x9gknd 11654 30 an an DT cord-010119-t1x9gknd 11654 31 outpatient outpatient NN cord-010119-t1x9gknd 11654 32 cancer cancer NN cord-010119-t1x9gknd 11654 33 center center NN cord-010119-t1x9gknd 11654 34 . . . cord-010119-t1x9gknd 11655 1 Study Study NNP cord-010119-t1x9gknd 11655 2 Design Design NNP cord-010119-t1x9gknd 11655 3 / / SYM cord-010119-t1x9gknd 11655 4 Method method NN cord-010119-t1x9gknd 11655 5 : : : cord-010119-t1x9gknd 11655 6 Before before IN cord-010119-t1x9gknd 11655 7 initiation initiation NN cord-010119-t1x9gknd 11655 8 , , , cord-010119-t1x9gknd 11655 9 approval approval NN cord-010119-t1x9gknd 11655 10 and and CC cord-010119-t1x9gknd 11655 11 funding funding NN cord-010119-t1x9gknd 11655 12 were be VBD cord-010119-t1x9gknd 11655 13 obtained obtain VBN cord-010119-t1x9gknd 11655 14 from from IN cord-010119-t1x9gknd 11655 15 the the DT cord-010119-t1x9gknd 11655 16 hospital hospital NN cord-010119-t1x9gknd 11655 17 quality quality NNP cord-010119-t1x9gknd 11655 18 council council NNP cord-010119-t1x9gknd 11655 19 and and CC cord-010119-t1x9gknd 11655 20 administration administration NN cord-010119-t1x9gknd 11655 21 , , , cord-010119-t1x9gknd 11655 22 and and CC cord-010119-t1x9gknd 11655 23 stakeholder stakeholder NN cord-010119-t1x9gknd 11655 24 groups group NNS cord-010119-t1x9gknd 11655 25 such such JJ cord-010119-t1x9gknd 11655 26 as as IN cord-010119-t1x9gknd 11655 27 hematology hematology NN cord-010119-t1x9gknd 11655 28 / / SYM cord-010119-t1x9gknd 11655 29 oncology oncology NN cord-010119-t1x9gknd 11655 30 were be VBD cord-010119-t1x9gknd 11655 31 educated educate VBN cord-010119-t1x9gknd 11655 32 and and CC cord-010119-t1x9gknd 11655 33 consensus consensus NN cord-010119-t1x9gknd 11655 34 gained gain VBD cord-010119-t1x9gknd 11655 35 . . . cord-010119-t1x9gknd 11656 1 Live live JJ cord-010119-t1x9gknd 11656 2 training training NN cord-010119-t1x9gknd 11656 3 was be VBD cord-010119-t1x9gknd 11656 4 provided provide VBN cord-010119-t1x9gknd 11656 5 for for IN cord-010119-t1x9gknd 11656 6 nurses nurse NNS cord-010119-t1x9gknd 11656 7 in in IN cord-010119-t1x9gknd 11656 8 the the DT cord-010119-t1x9gknd 11656 9 outpatient outpatient NN cord-010119-t1x9gknd 11656 10 cancer cancer NN cord-010119-t1x9gknd 11656 11 center center NN cord-010119-t1x9gknd 11656 12 ( ( -LRB- cord-010119-t1x9gknd 11656 13 week week NN cord-010119-t1x9gknd 11656 14 0 0 CD cord-010119-t1x9gknd 11656 15 ) ) -RRB- cord-010119-t1x9gknd 11656 16 and and CC cord-010119-t1x9gknd 11656 17 the the DT cord-010119-t1x9gknd 11656 18 bone bone NN cord-010119-t1x9gknd 11656 19 marrow marrow NN cord-010119-t1x9gknd 11656 20 transplant transplant NN cord-010119-t1x9gknd 11656 21 ( ( -LRB- cord-010119-t1x9gknd 11656 22 BMT BMT NNP cord-010119-t1x9gknd 11656 23 ) ) -RRB- cord-010119-t1x9gknd 11656 24 ward ward NNP cord-010119-t1x9gknd 11656 25 ( ( -LRB- cord-010119-t1x9gknd 11656 26 week week NN cord-010119-t1x9gknd 11656 27 6 6 CD cord-010119-t1x9gknd 11656 28 ) ) -RRB- cord-010119-t1x9gknd 11656 29 . . . cord-010119-t1x9gknd 11657 1 An an DT cord-010119-t1x9gknd 11657 2 e e NN cord-010119-t1x9gknd 11657 3 - - NN cord-010119-t1x9gknd 11657 4 mail mail NN cord-010119-t1x9gknd 11657 5 communication communication NN cord-010119-t1x9gknd 11657 6 explained explain VBD cord-010119-t1x9gknd 11657 7 the the DT cord-010119-t1x9gknd 11657 8 change change NN cord-010119-t1x9gknd 11657 9 to to IN cord-010119-t1x9gknd 11657 10 all all DT cord-010119-t1x9gknd 11657 11 physicians physician NNS cord-010119-t1x9gknd 11657 12 and and CC cord-010119-t1x9gknd 11657 13 nurses nurse NNS cord-010119-t1x9gknd 11657 14 . . . cord-010119-t1x9gknd 11658 1 In in IN cord-010119-t1x9gknd 11658 2 Phase phase NN cord-010119-t1x9gknd 11658 3 1 1 CD cord-010119-t1x9gknd 11658 4 , , , cord-010119-t1x9gknd 11658 5 we -PRON- PRP cord-010119-t1x9gknd 11658 6 implemented implement VBD cord-010119-t1x9gknd 11658 7 PRP PRP NNP cord-010119-t1x9gknd 11658 8 in in IN cord-010119-t1x9gknd 11658 9 the the DT cord-010119-t1x9gknd 11658 10 outpatient outpatient NN cord-010119-t1x9gknd 11658 11 cancer cancer NN cord-010119-t1x9gknd 11658 12 center center NN cord-010119-t1x9gknd 11658 13 . . . cord-010119-t1x9gknd 11659 1 These these DT cord-010119-t1x9gknd 11659 2 patients patient NNS cord-010119-t1x9gknd 11659 3 are be VBP cord-010119-t1x9gknd 11659 4 immunocompromised immunocompromised JJ cord-010119-t1x9gknd 11659 5 and and CC cord-010119-t1x9gknd 11659 6 do do VBP cord-010119-t1x9gknd 11659 7 not not RB cord-010119-t1x9gknd 11659 8 have have VB cord-010119-t1x9gknd 11659 9 access access NN cord-010119-t1x9gknd 11659 10 to to IN cord-010119-t1x9gknd 11659 11 the the DT cord-010119-t1x9gknd 11659 12 immediate immediate JJ cord-010119-t1x9gknd 11659 13 advanced advanced JJ cord-010119-t1x9gknd 11659 14 critical critical JJ cord-010119-t1x9gknd 11659 15 care care NN cord-010119-t1x9gknd 11659 16 of of IN cord-010119-t1x9gknd 11659 17 the the DT cord-010119-t1x9gknd 11659 18 inpatient inpatient JJ cord-010119-t1x9gknd 11659 19 environment environment NN cord-010119-t1x9gknd 11659 20 should should MD cord-010119-t1x9gknd 11659 21 a a DT cord-010119-t1x9gknd 11659 22 septic septic JJ cord-010119-t1x9gknd 11659 23 reaction reaction NN cord-010119-t1x9gknd 11659 24 occur occur VBP cord-010119-t1x9gknd 11659 25 . . . cord-010119-t1x9gknd 11660 1 In in IN cord-010119-t1x9gknd 11660 2 Phase phase NN cord-010119-t1x9gknd 11660 3 2 2 CD cord-010119-t1x9gknd 11660 4 , , , cord-010119-t1x9gknd 11660 5 we -PRON- PRP cord-010119-t1x9gknd 11660 6 expanded expand VBD cord-010119-t1x9gknd 11660 7 usage usage NN cord-010119-t1x9gknd 11660 8 to to TO cord-010119-t1x9gknd 11660 9 include include VB cord-010119-t1x9gknd 11660 10 the the DT cord-010119-t1x9gknd 11660 11 inpatient inpatient JJ cord-010119-t1x9gknd 11660 12 BMT BMT NNP cord-010119-t1x9gknd 11660 13 ward ward NNP cord-010119-t1x9gknd 11660 14 . . . cord-010119-t1x9gknd 11661 1 In in IN cord-010119-t1x9gknd 11661 2 Phase phase NN cord-010119-t1x9gknd 11661 3 3 3 CD cord-010119-t1x9gknd 11661 4 , , , cord-010119-t1x9gknd 11661 5 we -PRON- PRP cord-010119-t1x9gknd 11661 6 lifted lift VBD cord-010119-t1x9gknd 11661 7 all all DT cord-010119-t1x9gknd 11661 8 restrictions restriction NNS cord-010119-t1x9gknd 11661 9 so so IN cord-010119-t1x9gknd 11661 10 PRP PRP NNP cord-010119-t1x9gknd 11661 11 could could MD cord-010119-t1x9gknd 11661 12 be be VB cord-010119-t1x9gknd 11661 13 used use VBN cord-010119-t1x9gknd 11661 14 throughout throughout IN cord-010119-t1x9gknd 11661 15 the the DT cord-010119-t1x9gknd 11661 16 health health NN cord-010119-t1x9gknd 11661 17 system system NN cord-010119-t1x9gknd 11661 18 , , , cord-010119-t1x9gknd 11661 19 with with IN cord-010119-t1x9gknd 11661 20 the the DT cord-010119-t1x9gknd 11661 21 goal goal NN cord-010119-t1x9gknd 11661 22 to to TO cord-010119-t1x9gknd 11661 23 reach reach VB cord-010119-t1x9gknd 11661 24 100 100 CD cord-010119-t1x9gknd 11661 25 % % NN cord-010119-t1x9gknd 11661 26 PRP prp NN cord-010119-t1x9gknd 11661 27 within within IN cord-010119-t1x9gknd 11661 28 6 6 CD cord-010119-t1x9gknd 11661 29 months month NNS cord-010119-t1x9gknd 11661 30 . . . cord-010119-t1x9gknd 11662 1 Results result NNS cord-010119-t1x9gknd 11662 2 / / SYM cord-010119-t1x9gknd 11662 3 Finding finding NN cord-010119-t1x9gknd 11662 4 : : : cord-010119-t1x9gknd 11662 5 In in IN cord-010119-t1x9gknd 11662 6 Phase phase NN cord-010119-t1x9gknd 11662 7 1 1 CD cord-010119-t1x9gknd 11662 8 ( ( -LRB- cord-010119-t1x9gknd 11662 9 weeks week NNS cord-010119-t1x9gknd 11662 10 1 1 CD cord-010119-t1x9gknd 11662 11 - - SYM cord-010119-t1x9gknd 11662 12 6 6 CD cord-010119-t1x9gknd 11662 13 ) ) -RRB- cord-010119-t1x9gknd 11662 14 , , , cord-010119-t1x9gknd 11662 15 we -PRON- PRP cord-010119-t1x9gknd 11662 16 requested request VBD cord-010119-t1x9gknd 11662 17 31 31 CD cord-010119-t1x9gknd 11662 18 PRP PRP NNP cord-010119-t1x9gknd 11662 19 products product NNS cord-010119-t1x9gknd 11662 20 weekly weekly RB cord-010119-t1x9gknd 11662 21 , , , cord-010119-t1x9gknd 11662 22 based base VBN cord-010119-t1x9gknd 11662 23 on on IN cord-010119-t1x9gknd 11662 24 typical typical JJ cord-010119-t1x9gknd 11662 25 usage usage NN cord-010119-t1x9gknd 11662 26 in in IN cord-010119-t1x9gknd 11662 27 the the DT cord-010119-t1x9gknd 11662 28 outpatient outpatient NN cord-010119-t1x9gknd 11662 29 cancer cancer NN cord-010119-t1x9gknd 11662 30 center center NN cord-010119-t1x9gknd 11662 31 . . . cord-010119-t1x9gknd 11663 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11663 2 blood blood NN cord-010119-t1x9gknd 11663 3 supplier supplier NN cord-010119-t1x9gknd 11663 4 provided provide VBD cord-010119-t1x9gknd 11663 5 an an DT cord-010119-t1x9gknd 11663 6 average average NN cord-010119-t1x9gknd 11663 7 of of IN cord-010119-t1x9gknd 11663 8 23 23 CD cord-010119-t1x9gknd 11663 9 PRP PRP NNP cord-010119-t1x9gknd 11663 10 weekly weekly NN cord-010119-t1x9gknd 11663 11 ( ( -LRB- cord-010119-t1x9gknd 11663 12 range range NN cord-010119-t1x9gknd 11663 13 9 9 CD cord-010119-t1x9gknd 11663 14 - - SYM cord-010119-t1x9gknd 11663 15 33 33 CD cord-010119-t1x9gknd 11663 16 ) ) -RRB- cord-010119-t1x9gknd 11663 17 , , , cord-010119-t1x9gknd 11663 18 and and CC cord-010119-t1x9gknd 11663 19 PRP PRP NNP cord-010119-t1x9gknd 11663 20 constituted constitute VBD cord-010119-t1x9gknd 11663 21 44 44 CD cord-010119-t1x9gknd 11663 22 % % NN cord-010119-t1x9gknd 11663 23 of of IN cord-010119-t1x9gknd 11663 24 platelet platelet NN cord-010119-t1x9gknd 11663 25 transfusions transfusion NNS cord-010119-t1x9gknd 11663 26 in in IN cord-010119-t1x9gknd 11663 27 the the DT cord-010119-t1x9gknd 11663 28 cancer cancer NN cord-010119-t1x9gknd 11663 29 center center NN cord-010119-t1x9gknd 11663 30 . . . cord-010119-t1x9gknd 11664 1 In in IN cord-010119-t1x9gknd 11664 2 week week NN cord-010119-t1x9gknd 11664 3 2 2 CD cord-010119-t1x9gknd 11664 4 , , , cord-010119-t1x9gknd 11664 5 excess excess JJ cord-010119-t1x9gknd 11664 6 PRP PRP NNP cord-010119-t1x9gknd 11664 7 inventory inventory NN cord-010119-t1x9gknd 11664 8 required require VBN cord-010119-t1x9gknd 11664 9 use use NN cord-010119-t1x9gknd 11664 10 of of IN cord-010119-t1x9gknd 11664 11 PRP PRP NNP cord-010119-t1x9gknd 11664 12 in in IN cord-010119-t1x9gknd 11664 13 the the DT cord-010119-t1x9gknd 11664 14 inpatient inpatient JJ cord-010119-t1x9gknd 11664 15 BMT BMT NNP cord-010119-t1x9gknd 11664 16 ward ward VBN cord-010119-t1x9gknd 11664 17 ahead ahead RB cord-010119-t1x9gknd 11664 18 of of IN cord-010119-t1x9gknd 11664 19 schedule schedule NN cord-010119-t1x9gknd 11664 20 , , , cord-010119-t1x9gknd 11664 21 a a DT cord-010119-t1x9gknd 11664 22 practice practice NN cord-010119-t1x9gknd 11664 23 which which WDT cord-010119-t1x9gknd 11664 24 continued continue VBD cord-010119-t1x9gknd 11664 25 throughout throughout IN cord-010119-t1x9gknd 11664 26 Phase phase NN cord-010119-t1x9gknd 11664 27 1 1 CD cord-010119-t1x9gknd 11664 28 . . . cord-010119-t1x9gknd 11665 1 In in IN cord-010119-t1x9gknd 11665 2 Phase phase NN cord-010119-t1x9gknd 11665 3 2 2 CD cord-010119-t1x9gknd 11665 4 ( ( -LRB- cord-010119-t1x9gknd 11665 5 weeks week NNS cord-010119-t1x9gknd 11665 6 7 7 CD cord-010119-t1x9gknd 11665 7 - - SYM cord-010119-t1x9gknd 11665 8 8 8 CD cord-010119-t1x9gknd 11665 9 ) ) -RRB- cord-010119-t1x9gknd 11665 10 , , , cord-010119-t1x9gknd 11665 11 we -PRON- PRP cord-010119-t1x9gknd 11665 12 formally formally RB cord-010119-t1x9gknd 11665 13 expanded expand VBD cord-010119-t1x9gknd 11665 14 issuing issuing NN cord-010119-t1x9gknd 11665 15 of of IN cord-010119-t1x9gknd 11665 16 PRP PRP NNP cord-010119-t1x9gknd 11665 17 to to TO cord-010119-t1x9gknd 11665 18 include include VB cord-010119-t1x9gknd 11665 19 the the DT cord-010119-t1x9gknd 11665 20 inpatient inpatient JJ cord-010119-t1x9gknd 11665 21 BMT BMT NNP cord-010119-t1x9gknd 11665 22 ward ward NNP cord-010119-t1x9gknd 11665 23 and and CC cord-010119-t1x9gknd 11665 24 requested request VBD cord-010119-t1x9gknd 11665 25 91 91 CD cord-010119-t1x9gknd 11665 26 PRP PRP NNP cord-010119-t1x9gknd 11665 27 products product NNS cord-010119-t1x9gknd 11665 28 weekly weekly RB cord-010119-t1x9gknd 11665 29 . . . cord-010119-t1x9gknd 11666 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11666 2 blood blood NN cord-010119-t1x9gknd 11666 3 supplier supplier NN cord-010119-t1x9gknd 11666 4 provided provide VBD cord-010119-t1x9gknd 11666 5 an an DT cord-010119-t1x9gknd 11666 6 average average NN cord-010119-t1x9gknd 11666 7 of of IN cord-010119-t1x9gknd 11666 8 57 57 CD cord-010119-t1x9gknd 11666 9 PRP PRP NNP cord-010119-t1x9gknd 11666 10 weekly weekly NN cord-010119-t1x9gknd 11666 11 ( ( -LRB- cord-010119-t1x9gknd 11666 12 range range NN cord-010119-t1x9gknd 11666 13 44 44 CD cord-010119-t1x9gknd 11666 14 - - SYM cord-010119-t1x9gknd 11666 15 69 69 CD cord-010119-t1x9gknd 11666 16 ) ) -RRB- cord-010119-t1x9gknd 11666 17 , , , cord-010119-t1x9gknd 11666 18 and and CC cord-010119-t1x9gknd 11666 19 PRP PRP NNP cord-010119-t1x9gknd 11666 20 constituted constitute VBD cord-010119-t1x9gknd 11666 21 53 53 CD cord-010119-t1x9gknd 11666 22 % % NN cord-010119-t1x9gknd 11666 23 of of IN cord-010119-t1x9gknd 11666 24 platelet platelet NN cord-010119-t1x9gknd 11666 25 transfusions transfusion NNS cord-010119-t1x9gknd 11666 26 in in IN cord-010119-t1x9gknd 11666 27 the the DT cord-010119-t1x9gknd 11666 28 phased phase VBN cord-010119-t1x9gknd 11666 29 - - HYPH cord-010119-t1x9gknd 11666 30 in in RP cord-010119-t1x9gknd 11666 31 areas area NNS cord-010119-t1x9gknd 11666 32 . . . cord-010119-t1x9gknd 11667 1 In in IN cord-010119-t1x9gknd 11667 2 Phase phase NN cord-010119-t1x9gknd 11667 3 3 3 CD cord-010119-t1x9gknd 11667 4 ( ( -LRB- cord-010119-t1x9gknd 11667 5 weeks week NNS cord-010119-t1x9gknd 11667 6 9 9 CD cord-010119-t1x9gknd 11667 7 - - SYM cord-010119-t1x9gknd 11667 8 10 10 CD cord-010119-t1x9gknd 11667 9 ) ) -RRB- cord-010119-t1x9gknd 11667 10 , , , cord-010119-t1x9gknd 11667 11 we -PRON- PRP cord-010119-t1x9gknd 11667 12 began begin VBD cord-010119-t1x9gknd 11667 13 issuing issue VBG cord-010119-t1x9gknd 11667 14 PRP PRP NNP cord-010119-t1x9gknd 11667 15 throughout throughout IN cord-010119-t1x9gknd 11667 16 the the DT cord-010119-t1x9gknd 11667 17 health health NN cord-010119-t1x9gknd 11667 18 system system NN cord-010119-t1x9gknd 11667 19 . . . cord-010119-t1x9gknd 11668 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11668 2 supplier supplier NN cord-010119-t1x9gknd 11668 3 provided provide VBD cord-010119-t1x9gknd 11668 4 an an DT cord-010119-t1x9gknd 11668 5 average average NN cord-010119-t1x9gknd 11668 6 of of IN cord-010119-t1x9gknd 11668 7 70 70 CD cord-010119-t1x9gknd 11668 8 PRP PRP NNP cord-010119-t1x9gknd 11668 9 weekly weekly NN cord-010119-t1x9gknd 11668 10 ( ( -LRB- cord-010119-t1x9gknd 11668 11 range range NN cord-010119-t1x9gknd 11668 12 61 61 CD cord-010119-t1x9gknd 11668 13 - - SYM cord-010119-t1x9gknd 11668 14 78 78 CD cord-010119-t1x9gknd 11668 15 ) ) -RRB- cord-010119-t1x9gknd 11668 16 , , , cord-010119-t1x9gknd 11668 17 and and CC cord-010119-t1x9gknd 11668 18 PRP PRP NNP cord-010119-t1x9gknd 11668 19 constituted constitute VBD cord-010119-t1x9gknd 11668 20 43 43 CD cord-010119-t1x9gknd 11668 21 % % NN cord-010119-t1x9gknd 11668 22 of of IN cord-010119-t1x9gknd 11668 23 all all DT cord-010119-t1x9gknd 11668 24 platelet platelet NN cord-010119-t1x9gknd 11668 25 transfusions transfusion NNS cord-010119-t1x9gknd 11668 26 . . . cord-010119-t1x9gknd 11669 1 Scaling scaling NN cord-010119-t1x9gknd 11669 2 - - HYPH cord-010119-t1x9gknd 11669 3 up up NN cord-010119-t1x9gknd 11669 4 is be VBZ cord-010119-t1x9gknd 11669 5 ongoing ongoing JJ cord-010119-t1x9gknd 11669 6 . . . cord-010119-t1x9gknd 11670 1 Conclusion conclusion NN cord-010119-t1x9gknd 11670 2 : : : cord-010119-t1x9gknd 11671 1 Phased phase VBN cord-010119-t1x9gknd 11671 2 implementation implementation NN cord-010119-t1x9gknd 11671 3 of of IN cord-010119-t1x9gknd 11671 4 PRP PRP NNP cord-010119-t1x9gknd 11671 5 by by IN cord-010119-t1x9gknd 11671 6 patient patient JJ cord-010119-t1x9gknd 11671 7 group group NN cord-010119-t1x9gknd 11671 8 prioritizes prioritize VBZ cord-010119-t1x9gknd 11671 9 patients patient NNS cord-010119-t1x9gknd 11671 10 who who WP cord-010119-t1x9gknd 11671 11 stand stand VBP cord-010119-t1x9gknd 11671 12 to to TO cord-010119-t1x9gknd 11671 13 benefit benefit VB cord-010119-t1x9gknd 11671 14 most most JJS cord-010119-t1x9gknd 11671 15 from from IN cord-010119-t1x9gknd 11671 16 the the DT cord-010119-t1x9gknd 11671 17 product product NN cord-010119-t1x9gknd 11671 18 , , , cord-010119-t1x9gknd 11671 19 and and CC cord-010119-t1x9gknd 11671 20 allows allow VBZ cord-010119-t1x9gknd 11671 21 time time NN cord-010119-t1x9gknd 11671 22 for for IN cord-010119-t1x9gknd 11671 23 the the DT cord-010119-t1x9gknd 11671 24 blood blood NN cord-010119-t1x9gknd 11671 25 center center NN cord-010119-t1x9gknd 11671 26 to to TO cord-010119-t1x9gknd 11671 27 scale scale VB cord-010119-t1x9gknd 11671 28 up up RP cord-010119-t1x9gknd 11671 29 manufacturing manufacturing NN cord-010119-t1x9gknd 11671 30 . . . cord-010119-t1x9gknd 11671 31 _SP cord-010119-t1x9gknd 11672 1 Background Background NNP cord-010119-t1x9gknd 11672 2 / / SYM cord-010119-t1x9gknd 11672 3 Case Case NNP cord-010119-t1x9gknd 11672 4 Studies Studies NNPS cord-010119-t1x9gknd 11672 5 : : : cord-010119-t1x9gknd 11673 1 Maintaining maintain VBG cord-010119-t1x9gknd 11673 2 adequate adequate JJ cord-010119-t1x9gknd 11673 3 inventory inventory NN cord-010119-t1x9gknd 11673 4 of of IN cord-010119-t1x9gknd 11673 5 platelets platelet NNS cord-010119-t1x9gknd 11673 6 without without IN cord-010119-t1x9gknd 11673 7 significant significant JJ cord-010119-t1x9gknd 11673 8 outdating outdating NN cord-010119-t1x9gknd 11673 9 and and CC cord-010119-t1x9gknd 11673 10 waste waste NN cord-010119-t1x9gknd 11673 11 of of IN cord-010119-t1x9gknd 11673 12 product product NN cord-010119-t1x9gknd 11673 13 is be VBZ cord-010119-t1x9gknd 11673 14 a a DT cord-010119-t1x9gknd 11673 15 constant constant JJ cord-010119-t1x9gknd 11673 16 challenge challenge NN cord-010119-t1x9gknd 11673 17 for for IN cord-010119-t1x9gknd 11673 18 many many JJ cord-010119-t1x9gknd 11673 19 institutions institution NNS cord-010119-t1x9gknd 11673 20 , , , cord-010119-t1x9gknd 11673 21 especially especially RB cord-010119-t1x9gknd 11673 22 for for IN cord-010119-t1x9gknd 11673 23 smaller small JJR cord-010119-t1x9gknd 11673 24 community community NN cord-010119-t1x9gknd 11673 25 hospitals hospital NNS cord-010119-t1x9gknd 11673 26 . . . cord-010119-t1x9gknd 11674 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11674 2 Health Health NNP cord-010119-t1x9gknd 11674 3 System System NNP cord-010119-t1x9gknd 11674 4 comprises comprise VBZ cord-010119-t1x9gknd 11674 5 21 21 CD cord-010119-t1x9gknd 11674 6 hospitals hospital NNS cord-010119-t1x9gknd 11674 7 including include VBG cord-010119-t1x9gknd 11674 8 smaller small JJR cord-010119-t1x9gknd 11674 9 community community NN cord-010119-t1x9gknd 11674 10 hospitals hospital NNS cord-010119-t1x9gknd 11674 11 ( ( -LRB- cord-010119-t1x9gknd 11674 12 SCH SCH NNP cord-010119-t1x9gknd 11674 13 ) ) -RRB- cord-010119-t1x9gknd 11674 14 and and CC cord-010119-t1x9gknd 11674 15 larger large JJR cord-010119-t1x9gknd 11674 16 tertiary tertiary JJ cord-010119-t1x9gknd 11674 17 care care NN cord-010119-t1x9gknd 11674 18 medical medical JJ cord-010119-t1x9gknd 11674 19 centers center NNS cord-010119-t1x9gknd 11674 20 ( ( -LRB- cord-010119-t1x9gknd 11674 21 TCMC TCMC NNP cord-010119-t1x9gknd 11674 22 ) ) -RRB- cord-010119-t1x9gknd 11674 23 . . . cord-010119-t1x9gknd 11675 1 For for IN cord-010119-t1x9gknd 11675 2 several several JJ cord-010119-t1x9gknd 11675 3 years year NNS cord-010119-t1x9gknd 11675 4 , , , cord-010119-t1x9gknd 11675 5 we -PRON- PRP cord-010119-t1x9gknd 11675 6 have have VBP cord-010119-t1x9gknd 11675 7 been be VBN cord-010119-t1x9gknd 11675 8 using use VBG cord-010119-t1x9gknd 11675 9 a a DT cord-010119-t1x9gknd 11675 10 limited limited JJ cord-010119-t1x9gknd 11675 11 internal internal JJ cord-010119-t1x9gknd 11675 12 process process NN cord-010119-t1x9gknd 11675 13 of of IN cord-010119-t1x9gknd 11675 14 platelet platelet NN cord-010119-t1x9gknd 11675 15 sharing sharing NN cord-010119-t1x9gknd 11675 16 between between IN cord-010119-t1x9gknd 11675 17 some some DT cord-010119-t1x9gknd 11675 18 of of IN cord-010119-t1x9gknd 11675 19 our -PRON- PRP$ cord-010119-t1x9gknd 11675 20 institutions institution NNS cord-010119-t1x9gknd 11675 21 to to TO cord-010119-t1x9gknd 11675 22 successfully successfully RB cord-010119-t1x9gknd 11675 23 reduce reduce VB cord-010119-t1x9gknd 11675 24 platelet platelet NN cord-010119-t1x9gknd 11675 25 wastage wastage NN cord-010119-t1x9gknd 11675 26 . . . cord-010119-t1x9gknd 11676 1 This this DT cord-010119-t1x9gknd 11676 2 encouraged encourage VBD cord-010119-t1x9gknd 11676 3 us -PRON- PRP cord-010119-t1x9gknd 11676 4 to to TO cord-010119-t1x9gknd 11676 5 analyze analyze VB cord-010119-t1x9gknd 11676 6 platelet platelet NN cord-010119-t1x9gknd 11676 7 usage usage NN cord-010119-t1x9gknd 11676 8 throughout throughout IN cord-010119-t1x9gknd 11676 9 our -PRON- PRP$ cord-010119-t1x9gknd 11676 10 health health NN cord-010119-t1x9gknd 11676 11 system system NN cord-010119-t1x9gknd 11676 12 and and CC cord-010119-t1x9gknd 11676 13 devise devise VB cord-010119-t1x9gknd 11676 14 an an DT cord-010119-t1x9gknd 11676 15 expanded expand VBN cord-010119-t1x9gknd 11676 16 novel novel JJ cord-010119-t1x9gknd 11676 17 concept concept NN cord-010119-t1x9gknd 11676 18 of of IN cord-010119-t1x9gknd 11676 19 platelet platelet NN cord-010119-t1x9gknd 11676 20 distribution distribution NN cord-010119-t1x9gknd 11676 21 , , , cord-010119-t1x9gknd 11676 22 in in IN cord-010119-t1x9gknd 11676 23 partnership partnership NN cord-010119-t1x9gknd 11676 24 with with IN cord-010119-t1x9gknd 11676 25 our -PRON- PRP$ cord-010119-t1x9gknd 11676 26 blood blood NN cord-010119-t1x9gknd 11676 27 supplier supplier NN cord-010119-t1x9gknd 11676 28 that that WDT cord-010119-t1x9gknd 11676 29 would would MD cord-010119-t1x9gknd 11676 30 allow allow VB cord-010119-t1x9gknd 11676 31 us -PRON- PRP cord-010119-t1x9gknd 11676 32 to to TO cord-010119-t1x9gknd 11676 33 maintain maintain VB cord-010119-t1x9gknd 11676 34 an an DT cord-010119-t1x9gknd 11676 35 inventory inventory NN cord-010119-t1x9gknd 11676 36 of of IN cord-010119-t1x9gknd 11676 37 2 2 CD cord-010119-t1x9gknd 11676 38 apheresis apheresis NN cord-010119-t1x9gknd 11676 39 platelet platelet NN cord-010119-t1x9gknd 11676 40 ( ( -LRB- cord-010119-t1x9gknd 11676 41 AP AP NNP cord-010119-t1x9gknd 11676 42 ) ) -RRB- cord-010119-t1x9gknd 11676 43 units unit NNS cord-010119-t1x9gknd 11676 44 at at IN cord-010119-t1x9gknd 11676 45 our -PRON- PRP$ cord-010119-t1x9gknd 11676 46 smaller small JJR cord-010119-t1x9gknd 11676 47 community community NN cord-010119-t1x9gknd 11676 48 hospitals hospital NNS cord-010119-t1x9gknd 11676 49 without without IN cord-010119-t1x9gknd 11676 50 significantly significantly RB cord-010119-t1x9gknd 11676 51 increasing increase VBG cord-010119-t1x9gknd 11676 52 platelet platelet NN cord-010119-t1x9gknd 11676 53 waste waste NN cord-010119-t1x9gknd 11676 54 and and CC cord-010119-t1x9gknd 11676 55 the the DT cord-010119-t1x9gknd 11676 56 associated associate VBN cord-010119-t1x9gknd 11676 57 cost cost NN cord-010119-t1x9gknd 11676 58 . . . cord-010119-t1x9gknd 11677 1 Study Study NNP cord-010119-t1x9gknd 11677 2 Design Design NNP cord-010119-t1x9gknd 11677 3 / / SYM cord-010119-t1x9gknd 11677 4 Methods method NNS cord-010119-t1x9gknd 11677 5 : : : cord-010119-t1x9gknd 11678 1 A a DT cord-010119-t1x9gknd 11678 2 " " `` cord-010119-t1x9gknd 11678 3 Round Round NNP cord-010119-t1x9gknd 11678 4 Robin Robin NNP cord-010119-t1x9gknd 11678 5 " " '' cord-010119-t1x9gknd 11678 6 ( ( -LRB- cord-010119-t1x9gknd 11678 7 RR RR NNP cord-010119-t1x9gknd 11678 8 ) ) -RRB- cord-010119-t1x9gknd 11678 9 transportation transportation NN cord-010119-t1x9gknd 11678 10 system system NN cord-010119-t1x9gknd 11678 11 for for IN cord-010119-t1x9gknd 11678 12 platelet platelet NN cord-010119-t1x9gknd 11678 13 delivery delivery NN cord-010119-t1x9gknd 11678 14 and and CC cord-010119-t1x9gknd 11678 15 pick pick VB cord-010119-t1x9gknd 11678 16 up up RP cord-010119-t1x9gknd 11678 17 was be VBD cord-010119-t1x9gknd 11678 18 strategically strategically RB cord-010119-t1x9gknd 11678 19 developed develop VBN cord-010119-t1x9gknd 11678 20 with with IN cord-010119-t1x9gknd 11678 21 the the DT cord-010119-t1x9gknd 11678 22 regional regional JJ cord-010119-t1x9gknd 11678 23 blood blood NN cord-010119-t1x9gknd 11678 24 center center NN cord-010119-t1x9gknd 11678 25 to to TO cord-010119-t1x9gknd 11678 26 align align VB cord-010119-t1x9gknd 11678 27 with with IN cord-010119-t1x9gknd 11678 28 routine routine JJ cord-010119-t1x9gknd 11678 29 delivery delivery NN cord-010119-t1x9gknd 11678 30 of of IN cord-010119-t1x9gknd 11678 31 red red JJ cord-010119-t1x9gknd 11678 32 blood blood NN cord-010119-t1x9gknd 11678 33 cell cell NN cord-010119-t1x9gknd 11678 34 ( ( -LRB- cord-010119-t1x9gknd 11678 35 RBC RBC NNP cord-010119-t1x9gknd 11678 36 ) ) -RRB- cord-010119-t1x9gknd 11678 37 standing standing NN cord-010119-t1x9gknd 11678 38 orders order NNS cord-010119-t1x9gknd 11678 39 . . . cord-010119-t1x9gknd 11679 1 An an DT cord-010119-t1x9gknd 11679 2 efficient efficient JJ cord-010119-t1x9gknd 11679 3 delivery delivery NN cord-010119-t1x9gknd 11679 4 system system NN cord-010119-t1x9gknd 11679 5 was be VBD cord-010119-t1x9gknd 11679 6 implemented implement VBN cord-010119-t1x9gknd 11679 7 so so IN cord-010119-t1x9gknd 11679 8 that that IN cord-010119-t1x9gknd 11679 9 the the DT cord-010119-t1x9gknd 11679 10 regional regional JJ cord-010119-t1x9gknd 11679 11 blood blood NN cord-010119-t1x9gknd 11679 12 center center NN cord-010119-t1x9gknd 11679 13 would would MD cord-010119-t1x9gknd 11679 14 realize realize VB cord-010119-t1x9gknd 11679 15 reduced reduce VBN cord-010119-t1x9gknd 11679 16 supplemental supplemental JJ cord-010119-t1x9gknd 11679 17 and and CC cord-010119-t1x9gknd 11679 18 emergency emergency NN cord-010119-t1x9gknd 11679 19 deliveries delivery NNS cord-010119-t1x9gknd 11679 20 of of IN cord-010119-t1x9gknd 11679 21 blood blood NN cord-010119-t1x9gknd 11679 22 components component NNS cord-010119-t1x9gknd 11679 23 to to IN cord-010119-t1x9gknd 11679 24 our -PRON- PRP$ cord-010119-t1x9gknd 11679 25 hospitals hospital NNS cord-010119-t1x9gknd 11679 26 . . . cord-010119-t1x9gknd 11680 1 Platelets platelet NNS cord-010119-t1x9gknd 11680 2 are be VBP cord-010119-t1x9gknd 11680 3 transferred transfer VBN cord-010119-t1x9gknd 11680 4 at at IN cord-010119-t1x9gknd 11680 5 the the DT cord-010119-t1x9gknd 11680 6 time time NN cord-010119-t1x9gknd 11680 7 of of IN cord-010119-t1x9gknd 11680 8 RBC RBC NNP cord-010119-t1x9gknd 11680 9 standing stand VBG cord-010119-t1x9gknd 11680 10 order order NN cord-010119-t1x9gknd 11680 11 delivery delivery NN cord-010119-t1x9gknd 11680 12 based base VBN cord-010119-t1x9gknd 11680 13 on on IN cord-010119-t1x9gknd 11680 14 a a DT cord-010119-t1x9gknd 11680 15 predetermined predetermine VBN cord-010119-t1x9gknd 11680 16 route route NN cord-010119-t1x9gknd 11680 17 schedule schedule NN cord-010119-t1x9gknd 11680 18 . . . cord-010119-t1x9gknd 11681 1 Each each DT cord-010119-t1x9gknd 11681 2 day day NN cord-010119-t1x9gknd 11681 3 , , , cord-010119-t1x9gknd 11681 4 2 2 CD cord-010119-t1x9gknd 11681 5 AP AP NNP cord-010119-t1x9gknd 11681 6 are be VBP cord-010119-t1x9gknd 11681 7 delivered deliver VBN cord-010119-t1x9gknd 11681 8 to to IN cord-010119-t1x9gknd 11681 9 the the DT cord-010119-t1x9gknd 11681 10 SCH SCH NNP cord-010119-t1x9gknd 11681 11 and and CC cord-010119-t1x9gknd 11681 12 the the DT cord-010119-t1x9gknd 11681 13 previous previous JJ cord-010119-t1x9gknd 11681 14 day day NN cord-010119-t1x9gknd 11681 15 's 's POS cord-010119-t1x9gknd 11681 16 platelets platelet NNS cord-010119-t1x9gknd 11681 17 retrieved retrieve VBD cord-010119-t1x9gknd 11681 18 ( ( -LRB- cord-010119-t1x9gknd 11681 19 if if IN cord-010119-t1x9gknd 11681 20 not not RB cord-010119-t1x9gknd 11681 21 transfused transfuse VBN cord-010119-t1x9gknd 11681 22 ) ) -RRB- cord-010119-t1x9gknd 11681 23 , , , cord-010119-t1x9gknd 11681 24 packed pack VBN cord-010119-t1x9gknd 11681 25 in in IN cord-010119-t1x9gknd 11681 26 blood blood NN cord-010119-t1x9gknd 11681 27 center center NN cord-010119-t1x9gknd 11681 28 transport transport NN cord-010119-t1x9gknd 11681 29 boxes box NNS cord-010119-t1x9gknd 11681 30 , , , cord-010119-t1x9gknd 11681 31 and and CC cord-010119-t1x9gknd 11681 32 then then RB cord-010119-t1x9gknd 11681 33 picked pick VBD cord-010119-t1x9gknd 11681 34 up up RP cord-010119-t1x9gknd 11681 35 by by IN cord-010119-t1x9gknd 11681 36 the the DT cord-010119-t1x9gknd 11681 37 blood blood NN cord-010119-t1x9gknd 11681 38 center center NN cord-010119-t1x9gknd 11681 39 driver driver NN cord-010119-t1x9gknd 11681 40 . . . cord-010119-t1x9gknd 11682 1 These these DT cord-010119-t1x9gknd 11682 2 platelets platelet NNS cord-010119-t1x9gknd 11682 3 typically typically RB cord-010119-t1x9gknd 11682 4 have have VBP cord-010119-t1x9gknd 11682 5 a a DT cord-010119-t1x9gknd 11682 6 48 48 CD cord-010119-t1x9gknd 11682 7 hour hour NN cord-010119-t1x9gknd 11682 8 shelf shelf NN cord-010119-t1x9gknd 11682 9 life life NN cord-010119-t1x9gknd 11682 10 remaining remain VBG cord-010119-t1x9gknd 11682 11 . . . cord-010119-t1x9gknd 11683 1 The the DT cord-010119-t1x9gknd 11683 2 same same JJ cord-010119-t1x9gknd 11683 3 process process NN cord-010119-t1x9gknd 11683 4 occurs occur VBZ cord-010119-t1x9gknd 11683 5 at at IN cord-010119-t1x9gknd 11683 6 the the DT cord-010119-t1x9gknd 11683 7 next next JJ cord-010119-t1x9gknd 11683 8 SCH SCH NNP cord-010119-t1x9gknd 11683 9 on on IN cord-010119-t1x9gknd 11683 10 the the DT cord-010119-t1x9gknd 11683 11 route route NN cord-010119-t1x9gknd 11683 12 . . . cord-010119-t1x9gknd 11684 1 All all DT cord-010119-t1x9gknd 11684 2 retrieved retrieve VBN cord-010119-t1x9gknd 11685 1 platelets platelet NNS cord-010119-t1x9gknd 11685 2 from from IN cord-010119-t1x9gknd 11685 3 the the DT cord-010119-t1x9gknd 11685 4 SCH SCH NNP cord-010119-t1x9gknd 11685 5 are be VBP cord-010119-t1x9gknd 11685 6 delivered deliver VBN cord-010119-t1x9gknd 11685 7 to to IN cord-010119-t1x9gknd 11685 8 the the DT cord-010119-t1x9gknd 11685 9 TCMC TCMC NNP cord-010119-t1x9gknd 11685 10 which which WDT cord-010119-t1x9gknd 11685 11 is be VBZ cord-010119-t1x9gknd 11685 12 the the DT cord-010119-t1x9gknd 11685 13 last last JJ cord-010119-t1x9gknd 11685 14 stop stop NN cord-010119-t1x9gknd 11685 15 on on IN cord-010119-t1x9gknd 11685 16 the the DT cord-010119-t1x9gknd 11685 17 route route NN cord-010119-t1x9gknd 11685 18 . . . cord-010119-t1x9gknd 11686 1 Thus thus RB cord-010119-t1x9gknd 11686 2 , , , cord-010119-t1x9gknd 11686 3 the the DT cord-010119-t1x9gknd 11686 4 SCH SCH NNP cord-010119-t1x9gknd 11686 5 has have VBZ cord-010119-t1x9gknd 11686 6 adequate adequate JJ cord-010119-t1x9gknd 11686 7 number number NN cord-010119-t1x9gknd 11686 8 of of IN cord-010119-t1x9gknd 11686 9 units unit NNS cord-010119-t1x9gknd 11686 10 available available JJ cord-010119-t1x9gknd 11686 11 for for IN cord-010119-t1x9gknd 11686 12 regular regular JJ cord-010119-t1x9gknd 11686 13 transfusion transfusion NN cord-010119-t1x9gknd 11686 14 and and CC cord-010119-t1x9gknd 11686 15 massive massive JJ cord-010119-t1x9gknd 11686 16 transfusion transfusion NN cord-010119-t1x9gknd 11686 17 protocol protocol NN cord-010119-t1x9gknd 11686 18 . . . cord-010119-t1x9gknd 11687 1 Results result NNS cord-010119-t1x9gknd 11687 2 / / SYM cord-010119-t1x9gknd 11687 3 Findings finding NNS cord-010119-t1x9gknd 11687 4 : : : cord-010119-t1x9gknd 11687 5 Review Review NNP cord-010119-t1x9gknd 11687 6 of of IN cord-010119-t1x9gknd 11687 7 our -PRON- PRP$ cord-010119-t1x9gknd 11687 8 RR rr NN cord-010119-t1x9gknd 11687 9 process process NN cord-010119-t1x9gknd 11687 10 revealed reveal VBD cord-010119-t1x9gknd 11687 11 a a DT cord-010119-t1x9gknd 11687 12 significant significant JJ cord-010119-t1x9gknd 11687 13 benefit benefit NN cord-010119-t1x9gknd 11687 14 to to IN cord-010119-t1x9gknd 11687 15 our -PRON- PRP$ cord-010119-t1x9gknd 11687 16 smaller small JJR cord-010119-t1x9gknd 11687 17 community community NN cord-010119-t1x9gknd 11687 18 hospitals hospital NNS cord-010119-t1x9gknd 11687 19 as as IN cord-010119-t1x9gknd 11687 20 we -PRON- PRP cord-010119-t1x9gknd 11687 21 were be VBD cord-010119-t1x9gknd 11687 22 able able JJ cord-010119-t1x9gknd 11687 23 to to TO cord-010119-t1x9gknd 11687 24 routinely routinely RB cord-010119-t1x9gknd 11687 25 maintain maintain VB cord-010119-t1x9gknd 11687 26 an an DT cord-010119-t1x9gknd 11687 27 AP AP NNP cord-010119-t1x9gknd 11687 28 inventory inventory NN cord-010119-t1x9gknd 11687 29 for for IN cord-010119-t1x9gknd 11687 30 patients patient NNS cord-010119-t1x9gknd 11687 31 requiring require VBG cord-010119-t1x9gknd 11687 32 urgent urgent JJ cord-010119-t1x9gknd 11687 33 platelet platelet NN cord-010119-t1x9gknd 11687 34 transfusion transfusion NN cord-010119-t1x9gknd 11687 35 . . . cord-010119-t1x9gknd 11688 1 An an DT cord-010119-t1x9gknd 11688 2 additional additional JJ cord-010119-t1x9gknd 11688 3 benefit benefit NN cord-010119-t1x9gknd 11688 4 was be VBD cord-010119-t1x9gknd 11688 5 further further JJ cord-010119-t1x9gknd 11688 6 decrease decrease NN cord-010119-t1x9gknd 11688 7 in in IN cord-010119-t1x9gknd 11688 8 AP AP NNP cord-010119-t1x9gknd 11688 9 waste waste NN cord-010119-t1x9gknd 11688 10 ( ( -LRB- cord-010119-t1x9gknd 11688 11 Table table NN cord-010119-t1x9gknd 11688 12 1 1 CD cord-010119-t1x9gknd 11688 13 ) ) -RRB- cord-010119-t1x9gknd 11688 14 resulting result VBG cord-010119-t1x9gknd 11688 15 in in IN cord-010119-t1x9gknd 11688 16 a a DT cord-010119-t1x9gknd 11688 17 cost cost NN cord-010119-t1x9gknd 11688 18 savings saving NNS cord-010119-t1x9gknd 11688 19 of of IN cord-010119-t1x9gknd 11688 20 $ $ $ cord-010119-t1x9gknd 11688 21 50K. 50k. CD cord-010119-t1x9gknd 11688 22 An an DT cord-010119-t1x9gknd 11688 23 additional additional JJ cord-010119-t1x9gknd 11688 24 cost cost NN cord-010119-t1x9gknd 11688 25 savings saving NNS cord-010119-t1x9gknd 11688 26 of of IN cord-010119-t1x9gknd 11688 27 approximately approximately RB cord-010119-t1x9gknd 11688 28 $ $ $ cord-010119-t1x9gknd 11688 29 25 25 CD cord-010119-t1x9gknd 11689 1 K K NNP cord-010119-t1x9gknd 11689 2 was be VBD cord-010119-t1x9gknd 11689 3 noted note VBN cord-010119-t1x9gknd 11689 4 due due IN cord-010119-t1x9gknd 11689 5 to to IN cord-010119-t1x9gknd 11689 6 decreased decrease VBN cord-010119-t1x9gknd 11689 7 cost cost NN cord-010119-t1x9gknd 11689 8 of of IN cord-010119-t1x9gknd 11689 9 emergent emergent JJ cord-010119-t1x9gknd 11689 10 platelet platelet NN cord-010119-t1x9gknd 11689 11 transportation transportation NN cord-010119-t1x9gknd 11689 12 . . . cord-010119-t1x9gknd 11690 1 Conclusion conclusion NN cord-010119-t1x9gknd 11690 2 : : : cord-010119-t1x9gknd 11690 3 Our -PRON- PRP$ cord-010119-t1x9gknd 11690 4 novel novel NN cord-010119-t1x9gknd 11690 5 RR rr NN cord-010119-t1x9gknd 11690 6 process process NN cord-010119-t1x9gknd 11690 7 of of IN cord-010119-t1x9gknd 11690 8 platelet platelet NN cord-010119-t1x9gknd 11690 9 distribution distribution NN cord-010119-t1x9gknd 11690 10 has have VBZ cord-010119-t1x9gknd 11690 11 resulted result VBN cord-010119-t1x9gknd 11690 12 in in IN cord-010119-t1x9gknd 11690 13 improved improved JJ cord-010119-t1x9gknd 11690 14 platelet platelet NN cord-010119-t1x9gknd 11690 15 availability availability NN cord-010119-t1x9gknd 11690 16 at at IN cord-010119-t1x9gknd 11690 17 our -PRON- PRP$ cord-010119-t1x9gknd 11690 18 smaller small JJR cord-010119-t1x9gknd 11690 19 community community NN cord-010119-t1x9gknd 11690 20 hospitals hospital NNS cord-010119-t1x9gknd 11690 21 while while IN cord-010119-t1x9gknd 11690 22 maintaining maintain VBG cord-010119-t1x9gknd 11690 23 the the DT cord-010119-t1x9gknd 11690 24 reduced reduced JJ cord-010119-t1x9gknd 11690 25 level level NN cord-010119-t1x9gknd 11690 26 of of IN cord-010119-t1x9gknd 11690 27 AP AP NNP cord-010119-t1x9gknd 11690 28 waste waste NN cord-010119-t1x9gknd 11690 29 at at IN cord-010119-t1x9gknd 11690 30 our -PRON- PRP$ cord-010119-t1x9gknd 11690 31 health health NN cord-010119-t1x9gknd 11690 32 system system NN cord-010119-t1x9gknd 11690 33 from from IN cord-010119-t1x9gknd 11690 34 our -PRON- PRP$ cord-010119-t1x9gknd 11690 35 previous previous JJ cord-010119-t1x9gknd 11690 36 platelet platelet NN cord-010119-t1x9gknd 11690 37 sharing sharing NN cord-010119-t1x9gknd 11690 38 process process NN cord-010119-t1x9gknd 11690 39 . . . cord-010119-t1x9gknd 11691 1 We -PRON- PRP cord-010119-t1x9gknd 11691 2 anticipate anticipate VBP cord-010119-t1x9gknd 11691 3 additional additional JJ cord-010119-t1x9gknd 11691 4 decreases decrease NNS cord-010119-t1x9gknd 11691 5 in in IN cord-010119-t1x9gknd 11691 6 AP AP NNP cord-010119-t1x9gknd 11691 7 waste waste NN cord-010119-t1x9gknd 11691 8 as as IN cord-010119-t1x9gknd 11691 9 237A 237a CD cord-010119-t1x9gknd 11691 10 TRANSFUSION transfusion NN cord-010119-t1x9gknd 11691 11 2017 2017 CD cord-010119-t1x9gknd 11691 12 Vol Vol NNP cord-010119-t1x9gknd 11691 13 . . . cord-010119-t1x9gknd 11692 1 57 57 CD cord-010119-t1x9gknd 11692 2 Supplement supplement NN cord-010119-t1x9gknd 11692 3 S3 S3 NNP cord-010119-t1x9gknd 11692 4 we -PRON- PRP cord-010119-t1x9gknd 11692 5 further further RB cord-010119-t1x9gknd 11692 6 streamline streamline VBP cord-010119-t1x9gknd 11692 7 our -PRON- PRP$ cord-010119-t1x9gknd 11692 8 process process NN cord-010119-t1x9gknd 11692 9 . . . cord-010119-t1x9gknd 11693 1 With with IN cord-010119-t1x9gknd 11693 2 the the DT cord-010119-t1x9gknd 11693 3 trending trend VBG cord-010119-t1x9gknd 11693 4 merge merge NN cord-010119-t1x9gknd 11693 5 of of IN cord-010119-t1x9gknd 11693 6 health health NN cord-010119-t1x9gknd 11693 7 delivery delivery NN cord-010119-t1x9gknd 11693 8 systems system NNS cord-010119-t1x9gknd 11693 9 , , , cord-010119-t1x9gknd 11693 10 we -PRON- PRP cord-010119-t1x9gknd 11693 11 predict predict VBP cord-010119-t1x9gknd 11693 12 that that IN cord-010119-t1x9gknd 11693 13 other other JJ cord-010119-t1x9gknd 11693 14 health health NN cord-010119-t1x9gknd 11693 15 systems system NNS cord-010119-t1x9gknd 11693 16 will will MD cord-010119-t1x9gknd 11693 17 adopt adopt VB cord-010119-t1x9gknd 11693 18 similar similar JJ cord-010119-t1x9gknd 11693 19 processes process NNS cord-010119-t1x9gknd 11693 20 to to TO cord-010119-t1x9gknd 11693 21 improve improve VB cord-010119-t1x9gknd 11693 22 platelet platelet NN cord-010119-t1x9gknd 11693 23 availability availability NN cord-010119-t1x9gknd 11693 24 and and CC cord-010119-t1x9gknd 11693 25 reduce reduce VB cord-010119-t1x9gknd 11693 26 waste waste NN cord-010119-t1x9gknd 11693 27 . . . cord-010119-t1x9gknd 11694 1 Post Post NNP cord-010119-t1x9gknd 11694 2 Implementation implementation NN cord-010119-t1x9gknd 11694 3 Adjustments adjustment NNS cord-010119-t1x9gknd 11694 4 of of IN cord-010119-t1x9gknd 11694 5 Our -PRON- PRP$ cord-010119-t1x9gknd 11694 6 Pathogen Pathogen NNP cord-010119-t1x9gknd 11694 7 Reduction Reduction NNP cord-010119-t1x9gknd 11694 8 Process Process NNP cord-010119-t1x9gknd 11694 9 Jacqueline Jacqueline NNP cord-010119-t1x9gknd 11694 10 Carlson Carlson NNP cord-010119-t1x9gknd 11694 11 * * NFP cord-010119-t1x9gknd 11694 12 1 1 CD cord-010119-t1x9gknd 11694 13 , , , cord-010119-t1x9gknd 11694 14 James James NNP cord-010119-t1x9gknd 11694 15 R R NNP cord-010119-t1x9gknd 11694 16 Stubbs Stubbs NNP cord-010119-t1x9gknd 11694 17 1 1 CD cord-010119-t1x9gknd 11694 18 , , , cord-010119-t1x9gknd 11694 19 Scott Scott NNP cord-010119-t1x9gknd 11694 20 A A NNP cord-010119-t1x9gknd 11694 21 Hammel Hammel NNP cord-010119-t1x9gknd 11694 22 1 1 CD cord-010119-t1x9gknd 11694 23 and and CC cord-010119-t1x9gknd 11694 24 Manish Manish NNP cord-010119-t1x9gknd 11694 25 Gandhi Gandhi NNP cord-010119-t1x9gknd 11694 26 2 2 CD cord-010119-t1x9gknd 11694 27 . . . cord-010119-t1x9gknd 11694 28 1 1 CD cord-010119-t1x9gknd 11694 29 Mayo Mayo NNP cord-010119-t1x9gknd 11694 30 Clinic Clinic NNP cord-010119-t1x9gknd 11694 31 , , , cord-010119-t1x9gknd 11694 32 2 2 CD cord-010119-t1x9gknd 11694 33 Mayo Mayo NNP cord-010119-t1x9gknd 11694 34 Clinic Clinic NNP cord-010119-t1x9gknd 11694 35 - - HYPH cord-010119-t1x9gknd 11694 36 Rochester Rochester NNP cord-010119-t1x9gknd 11694 37 Background Background NNP cord-010119-t1x9gknd 11694 38 / / SYM cord-010119-t1x9gknd 11694 39 Case Case NNP cord-010119-t1x9gknd 11694 40 Studies Studies NNPS cord-010119-t1x9gknd 11694 41 : : : cord-010119-t1x9gknd 11695 1 The the DT cord-010119-t1x9gknd 11695 2 implementation implementation NN cord-010119-t1x9gknd 11695 3 of of IN cord-010119-t1x9gknd 11695 4 Pathogen Pathogen NNP cord-010119-t1x9gknd 11695 5 Reduction Reduction NNP cord-010119-t1x9gknd 11695 6 for for IN cord-010119-t1x9gknd 11695 7 Apheresis Apheresis NNP cord-010119-t1x9gknd 11695 8 Platelets platelet NNS cord-010119-t1x9gknd 11695 9 using use VBG cord-010119-t1x9gknd 11695 10 CerusV CerusV NNP cord-010119-t1x9gknd 11695 11 R R NNP cord-010119-t1x9gknd 11695 12 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 11695 13 System system NN cord-010119-t1x9gknd 11695 14 for for IN cord-010119-t1x9gknd 11695 15 Apheresis Apheresis NNP cord-010119-t1x9gknd 11695 16 Platelets Platelets NNPS cord-010119-t1x9gknd 11695 17 was be VBD cord-010119-t1x9gknd 11695 18 a a DT cord-010119-t1x9gknd 11695 19 substantial substantial JJ cord-010119-t1x9gknd 11695 20 endeavor endeavor NN cord-010119-t1x9gknd 11695 21 encompassing encompass VBG cord-010119-t1x9gknd 11695 22 many many JJ cord-010119-t1x9gknd 11695 23 different different JJ cord-010119-t1x9gknd 11695 24 areas area NNS cord-010119-t1x9gknd 11695 25 . . . cord-010119-t1x9gknd 11696 1 As as IN cord-010119-t1x9gknd 11696 2 with with IN cord-010119-t1x9gknd 11696 3 any any DT cord-010119-t1x9gknd 11696 4 process process NN cord-010119-t1x9gknd 11696 5 change change NN cord-010119-t1x9gknd 11696 6 , , , cord-010119-t1x9gknd 11696 7 adjustments adjustment NNS cord-010119-t1x9gknd 11696 8 and and CC cord-010119-t1x9gknd 11696 9 modifications modification NNS cord-010119-t1x9gknd 11696 10 can can MD cord-010119-t1x9gknd 11696 11 occur occur VB cord-010119-t1x9gknd 11696 12 along along IN cord-010119-t1x9gknd 11696 13 the the DT cord-010119-t1x9gknd 11696 14 way way NN cord-010119-t1x9gknd 11696 15 . . . cord-010119-t1x9gknd 11697 1 After after IN cord-010119-t1x9gknd 11697 2 implementing implement VBG cord-010119-t1x9gknd 11697 3 100 100 CD cord-010119-t1x9gknd 11697 4 % % NN cord-010119-t1x9gknd 11697 5 Pathogen Pathogen NNP cord-010119-t1x9gknd 11697 6 Reduction Reduction NNP cord-010119-t1x9gknd 11697 7 Technology Technology NNP cord-010119-t1x9gknd 11697 8 ( ( -LRB- cord-010119-t1x9gknd 11697 9 PRT PRT NNP cord-010119-t1x9gknd 11697 10 ) ) -RRB- cord-010119-t1x9gknd 11697 11 for for IN cord-010119-t1x9gknd 11697 12 Apheresis Apheresis NNP cord-010119-t1x9gknd 11697 13 Platelets Platelets NNPS cord-010119-t1x9gknd 11697 14 , , , cord-010119-t1x9gknd 11697 15 we -PRON- PRP cord-010119-t1x9gknd 11697 16 made make VBD cord-010119-t1x9gknd 11697 17 two two CD cord-010119-t1x9gknd 11697 18 additional additional JJ cord-010119-t1x9gknd 11697 19 adjustments adjustment NNS cord-010119-t1x9gknd 11697 20 to to IN cord-010119-t1x9gknd 11697 21 our -PRON- PRP$ cord-010119-t1x9gknd 11697 22 sampling sampling NN cord-010119-t1x9gknd 11697 23 processes process NNS cord-010119-t1x9gknd 11697 24 to to TO cord-010119-t1x9gknd 11697 25 ensure ensure VB cord-010119-t1x9gknd 11697 26 accurate accurate JJ cord-010119-t1x9gknd 11697 27 labeling labeling NN cord-010119-t1x9gknd 11697 28 / / SYM cord-010119-t1x9gknd 11697 29 categorization categorization NN cord-010119-t1x9gknd 11697 30 / / SYM cord-010119-t1x9gknd 11697 31 branding branding NN cord-010119-t1x9gknd 11697 32 of of IN cord-010119-t1x9gknd 11697 33 our -PRON- PRP$ cord-010119-t1x9gknd 11697 34 final final JJ cord-010119-t1x9gknd 11697 35 products product NNS cord-010119-t1x9gknd 11697 36 . . . cord-010119-t1x9gknd 11698 1 Study Study NNP cord-010119-t1x9gknd 11698 2 Design Design NNP cord-010119-t1x9gknd 11698 3 / / SYM cord-010119-t1x9gknd 11698 4 Method method NN cord-010119-t1x9gknd 11698 5 : : : cord-010119-t1x9gknd 11699 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11699 2 PRT PRT NNP cord-010119-t1x9gknd 11699 3 Validation Validation NNP cord-010119-t1x9gknd 11699 4 consisted consist VBD cord-010119-t1x9gknd 11699 5 of of IN cord-010119-t1x9gknd 11699 6 100 100 CD cord-010119-t1x9gknd 11699 7 Apheresis Apheresis NNP cord-010119-t1x9gknd 11699 8 platelet platelet NN cord-010119-t1x9gknd 11699 9 products product NNS cord-010119-t1x9gknd 11699 10 . . . cord-010119-t1x9gknd 11700 1 Each each DT cord-010119-t1x9gknd 11700 2 product product NN cord-010119-t1x9gknd 11700 3 was be VBD cord-010119-t1x9gknd 11700 4 tested test VBN cord-010119-t1x9gknd 11700 5 pre pre JJ cord-010119-t1x9gknd 11700 6 - - NN cord-010119-t1x9gknd 11700 7 processing processing NN cord-010119-t1x9gknd 11700 8 for for IN cord-010119-t1x9gknd 11700 9 white white JJ cord-010119-t1x9gknd 11700 10 blood blood NN cord-010119-t1x9gknd 11700 11 cell cell NN cord-010119-t1x9gknd 11700 12 ( ( -LRB- cord-010119-t1x9gknd 11700 13 WBC WBC NNP cord-010119-t1x9gknd 11700 14 ) ) -RRB- cord-010119-t1x9gknd 11700 15 content content NN cord-010119-t1x9gknd 11700 16 and and CC cord-010119-t1x9gknd 11700 17 platelet platelet NN cord-010119-t1x9gknd 11700 18 yield yield NN cord-010119-t1x9gknd 11700 19 , , , cord-010119-t1x9gknd 11700 20 along along IN cord-010119-t1x9gknd 11700 21 with with IN cord-010119-t1x9gknd 11700 22 post post JJ cord-010119-t1x9gknd 11700 23 processing processing NN cord-010119-t1x9gknd 11700 24 platelet platelet NN cord-010119-t1x9gknd 11700 25 yield yield NN cord-010119-t1x9gknd 11700 26 . . . cord-010119-t1x9gknd 11701 1 This this DT cord-010119-t1x9gknd 11701 2 data data NN cord-010119-t1x9gknd 11701 3 was be VBD cord-010119-t1x9gknd 11701 4 used use VBN cord-010119-t1x9gknd 11701 5 to to TO cord-010119-t1x9gknd 11701 6 calculate calculate VB cord-010119-t1x9gknd 11701 7 our -PRON- PRP$ cord-010119-t1x9gknd 11701 8 yield yield NN cord-010119-t1x9gknd 11701 9 and and CC cord-010119-t1x9gknd 11701 10 volume volume NN cord-010119-t1x9gknd 11701 11 retention retention NN cord-010119-t1x9gknd 11701 12 during during IN cord-010119-t1x9gknd 11701 13 processing processing NN cord-010119-t1x9gknd 11701 14 . . . cord-010119-t1x9gknd 11702 1 We -PRON- PRP cord-010119-t1x9gknd 11702 2 anticipated anticipate VBD cord-010119-t1x9gknd 11702 3 products product NNS cord-010119-t1x9gknd 11702 4 with with IN cord-010119-t1x9gknd 11702 5 preprocessing preprocessing NN cord-010119-t1x9gknd 11702 6 yields yield NNS cord-010119-t1x9gknd 11702 7 of of IN cord-010119-t1x9gknd 11702 8 3.0 3.0 CD cord-010119-t1x9gknd 11702 9 , , , cord-010119-t1x9gknd 11702 10 3.1 3.1 CD cord-010119-t1x9gknd 11702 11 , , , cord-010119-t1x9gknd 11702 12 and and CC cord-010119-t1x9gknd 11702 13 3.3 3.3 CD cord-010119-t1x9gknd 11702 14 x10 x10 CD cord-010119-t1x9gknd 11702 15 11 11 CD cord-010119-t1x9gknd 11702 16 may may MD cord-010119-t1x9gknd 11702 17 end end VB cord-010119-t1x9gknd 11702 18 up up RP cord-010119-t1x9gknd 11702 19 below below IN cord-010119-t1x9gknd 11702 20 a a DT cord-010119-t1x9gknd 11702 21 3.0 3.0 CD cord-010119-t1x9gknd 11702 22 in in IN cord-010119-t1x9gknd 11702 23 the the DT cord-010119-t1x9gknd 11702 24 final final JJ cord-010119-t1x9gknd 11702 25 storage storage NN cord-010119-t1x9gknd 11702 26 bag bag NN cord-010119-t1x9gknd 11702 27 and and CC cord-010119-t1x9gknd 11702 28 would would MD cord-010119-t1x9gknd 11702 29 need need VB cord-010119-t1x9gknd 11702 30 a a DT cord-010119-t1x9gknd 11702 31 post post JJ cord-010119-t1x9gknd 11702 32 - - JJ cord-010119-t1x9gknd 11702 33 processing processing JJ cord-010119-t1x9gknd 11702 34 sample sample NN cord-010119-t1x9gknd 11702 35 to to TO cord-010119-t1x9gknd 11702 36 ensure ensure VB cord-010119-t1x9gknd 11702 37 the the DT cord-010119-t1x9gknd 11702 38 product product NN cord-010119-t1x9gknd 11702 39 met meet VBD cord-010119-t1x9gknd 11702 40 criteria criterion NNS cord-010119-t1x9gknd 11702 41 at at IN cord-010119-t1x9gknd 11702 42 ! ! . cord-010119-t1x9gknd 11703 1 3.0x10 3.0x10 CD cord-010119-t1x9gknd 11703 2 11 11 CD cord-010119-t1x9gknd 11703 3 platelets platelet NNS cord-010119-t1x9gknd 11703 4 . . . cord-010119-t1x9gknd 11704 1 Results result NNS cord-010119-t1x9gknd 11705 1 /Finding /finde VBG cord-010119-t1x9gknd 11705 2 : : : cord-010119-t1x9gknd 11705 3 During during IN cord-010119-t1x9gknd 11705 4 the the DT cord-010119-t1x9gknd 11705 5 validation validation NN cord-010119-t1x9gknd 11705 6 , , , cord-010119-t1x9gknd 11705 7 we -PRON- PRP cord-010119-t1x9gknd 11705 8 discovered discover VBD cord-010119-t1x9gknd 11705 9 one one CD cord-010119-t1x9gknd 11705 10 collection collection NN cord-010119-t1x9gknd 11705 11 was be VBD cord-010119-t1x9gknd 11705 12 not not RB cord-010119-t1x9gknd 11705 13 leukoreduced leukoreduce VBN cord-010119-t1x9gknd 11705 14 and and CC cord-010119-t1x9gknd 11705 15 two two CD cord-010119-t1x9gknd 11705 16 collections collection NNS cord-010119-t1x9gknd 11705 17 started start VBD cord-010119-t1x9gknd 11705 18 at at IN cord-010119-t1x9gknd 11705 19 a a DT cord-010119-t1x9gknd 11705 20 3.4 3.4 CD cord-010119-t1x9gknd 11705 21 yield yield NN cord-010119-t1x9gknd 11705 22 but but CC cord-010119-t1x9gknd 11705 23 ended end VBD cord-010119-t1x9gknd 11705 24 with with IN cord-010119-t1x9gknd 11705 25 a a DT cord-010119-t1x9gknd 11705 26 yield yield NN cord-010119-t1x9gknd 11705 27 below below IN cord-010119-t1x9gknd 11705 28 3.0 3.0 CD cord-010119-t1x9gknd 11705 29 . . . cord-010119-t1x9gknd 11706 1 These these DT cord-010119-t1x9gknd 11706 2 two two CD cord-010119-t1x9gknd 11706 3 discoveries discovery NNS cord-010119-t1x9gknd 11706 4 led lead VBD cord-010119-t1x9gknd 11706 5 to to IN cord-010119-t1x9gknd 11706 6 adjustments adjustment NNS cord-010119-t1x9gknd 11706 7 in in IN cord-010119-t1x9gknd 11706 8 our -PRON- PRP$ cord-010119-t1x9gknd 11706 9 PRT PRT NNP cord-010119-t1x9gknd 11706 10 platelet platelet NN cord-010119-t1x9gknd 11706 11 process process NN cord-010119-t1x9gknd 11706 12 . . . cord-010119-t1x9gknd 11707 1 With with IN cord-010119-t1x9gknd 11707 2 the the DT cord-010119-t1x9gknd 11707 3 WBC WBC NNP cord-010119-t1x9gknd 11707 4 failure failure NN cord-010119-t1x9gknd 11707 5 , , , cord-010119-t1x9gknd 11707 6 we -PRON- PRP cord-010119-t1x9gknd 11707 7 reviewed review VBD cord-010119-t1x9gknd 11707 8 the the DT cord-010119-t1x9gknd 11707 9 WBC WBC NNP cord-010119-t1x9gknd 11707 10 count count NN cord-010119-t1x9gknd 11707 11 on on IN cord-010119-t1x9gknd 11707 12 the the DT cord-010119-t1x9gknd 11707 13 Sysmex Sysmex NNP cord-010119-t1x9gknd 11707 14 XE-2100D xe-2100d CD cord-010119-t1x9gknd 11707 15 preprocessing preprocessing NN cord-010119-t1x9gknd 11707 16 report report NN cord-010119-t1x9gknd 11707 17 to to TO cord-010119-t1x9gknd 11707 18 see see VB cord-010119-t1x9gknd 11707 19 if if IN cord-010119-t1x9gknd 11707 20 it -PRON- PRP cord-010119-t1x9gknd 11707 21 would would MD cord-010119-t1x9gknd 11707 22 alert alert VB cord-010119-t1x9gknd 11707 23 us -PRON- PRP cord-010119-t1x9gknd 11707 24 to to IN cord-010119-t1x9gknd 11707 25 a a DT cord-010119-t1x9gknd 11707 26 potential potential JJ cord-010119-t1x9gknd 11707 27 WBC WBC NNP cord-010119-t1x9gknd 11707 28 failure failure NN cord-010119-t1x9gknd 11707 29 . . . cord-010119-t1x9gknd 11708 1 The the DT cord-010119-t1x9gknd 11708 2 review review NN cord-010119-t1x9gknd 11708 3 discovered discover VBD cord-010119-t1x9gknd 11708 4 that that IN cord-010119-t1x9gknd 11708 5 99 99 CD cord-010119-t1x9gknd 11708 6 of of IN cord-010119-t1x9gknd 11708 7 100 100 CD cord-010119-t1x9gknd 11708 8 results result NNS cord-010119-t1x9gknd 11708 9 were be VBD cord-010119-t1x9gknd 11708 10 0.00 0.00 CD cord-010119-t1x9gknd 11708 11 or or CC cord-010119-t1x9gknd 11708 12 0.01x10 0.01x10 CD cord-010119-t1x9gknd 11708 13 3 3 CD cord-010119-t1x9gknd 11709 1 / / SYM cord-010119-t1x9gknd 11709 2 mcL mcl NN cord-010119-t1x9gknd 11709 3 with with IN cord-010119-t1x9gknd 11709 4 the the DT cord-010119-t1x9gknd 11709 5 exception exception NN cord-010119-t1x9gknd 11709 6 being be VBG cord-010119-t1x9gknd 11709 7 the the DT cord-010119-t1x9gknd 11709 8 WBC WBC NNP cord-010119-t1x9gknd 11709 9 failure failure NN cord-010119-t1x9gknd 11709 10 with with IN cord-010119-t1x9gknd 11709 11 a a DT cord-010119-t1x9gknd 11709 12 count count NN cord-010119-t1x9gknd 11709 13 of of IN cord-010119-t1x9gknd 11709 14 0.29 0.29 CD cord-010119-t1x9gknd 11709 15 . . . cord-010119-t1x9gknd 11710 1 Further further JJ cord-010119-t1x9gknd 11710 2 monitoring monitoring NN cord-010119-t1x9gknd 11710 3 of of IN cord-010119-t1x9gknd 11710 4 the the DT cord-010119-t1x9gknd 11710 5 WBC WBC NNP cord-010119-t1x9gknd 11710 6 counts count NNS cord-010119-t1x9gknd 11710 7 discovered discover VBD cord-010119-t1x9gknd 11710 8 a a DT cord-010119-t1x9gknd 11710 9 result result NN cord-010119-t1x9gknd 11710 10 of of IN cord-010119-t1x9gknd 11710 11 0.04 0.04 CD cord-010119-t1x9gknd 11710 12 which which WDT cord-010119-t1x9gknd 11710 13 was be VBD cord-010119-t1x9gknd 11710 14 tested test VBN cord-010119-t1x9gknd 11710 15 on on IN cord-010119-t1x9gknd 11710 16 the the DT cord-010119-t1x9gknd 11710 17 ADAM ADAM NNP cord-010119-t1x9gknd 11710 18 r r NNP cord-010119-t1x9gknd 11710 19 - - HYPH cord-010119-t1x9gknd 11710 20 WBC WBC NNP cord-010119-t1x9gknd 11710 21 for for IN cord-010119-t1x9gknd 11710 22 WBC WBC NNP cord-010119-t1x9gknd 11710 23 count count NN cord-010119-t1x9gknd 11710 24 and and CC cord-010119-t1x9gknd 11710 25 determined determine VBD cord-010119-t1x9gknd 11710 26 to to TO cord-010119-t1x9gknd 11710 27 not not RB cord-010119-t1x9gknd 11710 28 be be VB cord-010119-t1x9gknd 11710 29 leukoreduced leukoreduce VBN cord-010119-t1x9gknd 11710 30 . . . cord-010119-t1x9gknd 11711 1 We -PRON- PRP cord-010119-t1x9gknd 11711 2 decided decide VBD cord-010119-t1x9gknd 11711 3 all all DT cord-010119-t1x9gknd 11711 4 Sysmex Sysmex NNP cord-010119-t1x9gknd 11711 5 WBC WBC NNP cord-010119-t1x9gknd 11711 6 results result VBZ cord-010119-t1x9gknd 11711 7 from from IN cord-010119-t1x9gknd 11711 8 the the DT cord-010119-t1x9gknd 11711 9 pre pre JJ cord-010119-t1x9gknd 11711 10 - - JJ cord-010119-t1x9gknd 11711 11 processing process VBG cord-010119-t1x9gknd 11711 12 Sysmex Sysmex NNP cord-010119-t1x9gknd 11711 13 report report NN cord-010119-t1x9gknd 11711 14 would would MD cord-010119-t1x9gknd 11711 15 be be VB cord-010119-t1x9gknd 11711 16 reviewed review VBN cord-010119-t1x9gknd 11711 17 prior prior RB cord-010119-t1x9gknd 11711 18 to to IN cord-010119-t1x9gknd 11711 19 processing processing NN cord-010119-t1x9gknd 11711 20 and and CC cord-010119-t1x9gknd 11711 21 a a DT cord-010119-t1x9gknd 11711 22 WBC WBC NNP cord-010119-t1x9gknd 11711 23 result result NN cord-010119-t1x9gknd 11711 24 of of IN cord-010119-t1x9gknd 11711 25 0.03 0.03 CD cord-010119-t1x9gknd 11711 26 will will MD cord-010119-t1x9gknd 11711 27 be be VB cord-010119-t1x9gknd 11711 28 tested test VBN cord-010119-t1x9gknd 11711 29 on on IN cord-010119-t1x9gknd 11711 30 the the DT cord-010119-t1x9gknd 11711 31 ADAM ADAM NNP cord-010119-t1x9gknd 11711 32 to to TO cord-010119-t1x9gknd 11711 33 confirm confirm VB cord-010119-t1x9gknd 11711 34 a a DT cord-010119-t1x9gknd 11711 35 leukoreduced leukoreduced JJ cord-010119-t1x9gknd 11711 36 product product NN cord-010119-t1x9gknd 11711 37 . . . cord-010119-t1x9gknd 11712 1 We -PRON- PRP cord-010119-t1x9gknd 11712 2 also also RB cord-010119-t1x9gknd 11712 3 discovered discover VBD cord-010119-t1x9gknd 11712 4 2 2 CD cord-010119-t1x9gknd 11712 5 of of IN cord-010119-t1x9gknd 11712 6 4 4 CD cord-010119-t1x9gknd 11712 7 ( ( -LRB- cord-010119-t1x9gknd 11712 8 50 50 CD cord-010119-t1x9gknd 11712 9 % % NN cord-010119-t1x9gknd 11712 10 ) ) -RRB- cord-010119-t1x9gknd 11712 11 of of IN cord-010119-t1x9gknd 11712 12 the the DT cord-010119-t1x9gknd 11712 13 3.4 3.4 CD cord-010119-t1x9gknd 11712 14 preprocessing preprocessing NN cord-010119-t1x9gknd 11712 15 yields yield NNS cord-010119-t1x9gknd 11712 16 products product NNS cord-010119-t1x9gknd 11712 17 ended end VBD cord-010119-t1x9gknd 11712 18 with with IN cord-010119-t1x9gknd 11712 19 a a DT cord-010119-t1x9gknd 11712 20 post post JJ cord-010119-t1x9gknd 11712 21 processing processing NN cord-010119-t1x9gknd 11712 22 yield yield NN cord-010119-t1x9gknd 11712 23 < < XX cord-010119-t1x9gknd 11712 24 3.0 3.0 CD cord-010119-t1x9gknd 11712 25 . . . cord-010119-t1x9gknd 11713 1 We -PRON- PRP cord-010119-t1x9gknd 11713 2 decided decide VBD cord-010119-t1x9gknd 11713 3 to to TO cord-010119-t1x9gknd 11713 4 increase increase VB cord-010119-t1x9gknd 11713 5 the the DT cord-010119-t1x9gknd 11713 6 yields yield NNS cord-010119-t1x9gknd 11713 7 requiring require VBG cord-010119-t1x9gknd 11713 8 post post JJ cord-010119-t1x9gknd 11713 9 processing processing NN cord-010119-t1x9gknd 11713 10 samples sample NNS cord-010119-t1x9gknd 11713 11 to to TO cord-010119-t1x9gknd 11713 12 include include VB cord-010119-t1x9gknd 11713 13 the the DT cord-010119-t1x9gknd 11713 14 3.4 3.4 CD cord-010119-t1x9gknd 11713 15 . . . cord-010119-t1x9gknd 11714 1 Conclusion conclusion NN cord-010119-t1x9gknd 11714 2 : : : cord-010119-t1x9gknd 11714 3 We -PRON- PRP cord-010119-t1x9gknd 11714 4 are be VBP cord-010119-t1x9gknd 11714 5 continuing continue VBG cord-010119-t1x9gknd 11714 6 to to TO cord-010119-t1x9gknd 11714 7 sample sample VB cord-010119-t1x9gknd 11714 8 all all DT cord-010119-t1x9gknd 11714 9 collections collection NNS cord-010119-t1x9gknd 11714 10 for for IN cord-010119-t1x9gknd 11714 11 a a DT cord-010119-t1x9gknd 11714 12 post post JJ cord-010119-t1x9gknd 11714 13 processing processing NN cord-010119-t1x9gknd 11714 14 yield yield NN cord-010119-t1x9gknd 11714 15 so so IN cord-010119-t1x9gknd 11714 16 we -PRON- PRP cord-010119-t1x9gknd 11714 17 can can MD cord-010119-t1x9gknd 11714 18 be be VB cord-010119-t1x9gknd 11714 19 confident confident JJ cord-010119-t1x9gknd 11714 20 that that IN cord-010119-t1x9gknd 11714 21 we -PRON- PRP cord-010119-t1x9gknd 11714 22 are be VBP cord-010119-t1x9gknd 11714 23 releasing release VBG cord-010119-t1x9gknd 11714 24 products product NNS cord-010119-t1x9gknd 11714 25 into into IN cord-010119-t1x9gknd 11714 26 inventory inventory NN cord-010119-t1x9gknd 11714 27 with with IN cord-010119-t1x9gknd 11714 28 a a DT cord-010119-t1x9gknd 11714 29 yield yield NN cord-010119-t1x9gknd 11714 30 of of IN cord-010119-t1x9gknd 11714 31 ! ! . cord-010119-t1x9gknd 11715 1 3.0x10 3.0x10 CD cord-010119-t1x9gknd 11715 2 6 6 CD cord-010119-t1x9gknd 11715 3 platelets platelet NNS cord-010119-t1x9gknd 11715 4 and and CC cord-010119-t1x9gknd 11715 5 to to TO cord-010119-t1x9gknd 11715 6 have have VB cord-010119-t1x9gknd 11715 7 enough enough JJ cord-010119-t1x9gknd 11715 8 data datum NNS cord-010119-t1x9gknd 11715 9 to to TO cord-010119-t1x9gknd 11715 10 accurately accurately RB cord-010119-t1x9gknd 11715 11 determine determine VB cord-010119-t1x9gknd 11715 12 our -PRON- PRP$ cord-010119-t1x9gknd 11715 13 volume volume NN cord-010119-t1x9gknd 11715 14 and and CC cord-010119-t1x9gknd 11715 15 yield yield VB cord-010119-t1x9gknd 11715 16 loss loss NN cord-010119-t1x9gknd 11715 17 during during IN cord-010119-t1x9gknd 11715 18 processing process VBG cord-010119-t1x9gknd 11715 19 _SP cord-010119-t1x9gknd 11715 20 Background Background NNP cord-010119-t1x9gknd 11715 21 / / SYM cord-010119-t1x9gknd 11715 22 Case Case NNP cord-010119-t1x9gknd 11715 23 Studies Studies NNPS cord-010119-t1x9gknd 11715 24 : : : cord-010119-t1x9gknd 11715 25 The the DT cord-010119-t1x9gknd 11715 26 University University NNP cord-010119-t1x9gknd 11715 27 of of IN cord-010119-t1x9gknd 11715 28 Kentucky Kentucky NNP cord-010119-t1x9gknd 11715 29 Medical Medical NNP cord-010119-t1x9gknd 11715 30 Center Center NNP cord-010119-t1x9gknd 11715 31 ( ( -LRB- cord-010119-t1x9gknd 11715 32 UKMC UKMC NNP cord-010119-t1x9gknd 11715 33 ) ) -RRB- cord-010119-t1x9gknd 11715 34 , , , cord-010119-t1x9gknd 11715 35 a a DT cord-010119-t1x9gknd 11715 36 large large JJ cord-010119-t1x9gknd 11715 37 academic academic JJ cord-010119-t1x9gknd 11715 38 hospital hospital NN cord-010119-t1x9gknd 11715 39 with with IN cord-010119-t1x9gknd 11715 40 level level NN cord-010119-t1x9gknd 11715 41 I I NNP cord-010119-t1x9gknd 11715 42 trauma trauma NN cord-010119-t1x9gknd 11715 43 center center NN cord-010119-t1x9gknd 11715 44 , , , cord-010119-t1x9gknd 11715 45 is be VBZ cord-010119-t1x9gknd 11715 46 supplied supply VBN cord-010119-t1x9gknd 11715 47 with with IN cord-010119-t1x9gknd 11715 48 blood blood NN cord-010119-t1x9gknd 11715 49 products product NNS cord-010119-t1x9gknd 11715 50 by by IN cord-010119-t1x9gknd 11715 51 the the DT cord-010119-t1x9gknd 11715 52 Kentucky Kentucky NNP cord-010119-t1x9gknd 11715 53 Blood Blood NNP cord-010119-t1x9gknd 11715 54 Center Center NNP cord-010119-t1x9gknd 11715 55 ( ( -LRB- cord-010119-t1x9gknd 11715 56 KBC KBC NNP cord-010119-t1x9gknd 11715 57 ) ) -RRB- cord-010119-t1x9gknd 11715 58 on on IN cord-010119-t1x9gknd 11715 59 a a DT cord-010119-t1x9gknd 11715 60 consignment consignment NN cord-010119-t1x9gknd 11715 61 agreement agreement NN cord-010119-t1x9gknd 11715 62 - - HYPH cord-010119-t1x9gknd 11715 63 based base VBN cord-010119-t1x9gknd 11715 64 contract contract NN cord-010119-t1x9gknd 11715 65 . . . cord-010119-t1x9gknd 11716 1 UKMC UKMC NNP cord-010119-t1x9gknd 11716 2 is be VBZ cord-010119-t1x9gknd 11716 3 KBC KBC NNP cord-010119-t1x9gknd 11716 4 's 's POS cord-010119-t1x9gknd 11716 5 largest large JJS cord-010119-t1x9gknd 11716 6 consumer consumer NN cord-010119-t1x9gknd 11716 7 of of IN cord-010119-t1x9gknd 11716 8 blood blood NN cord-010119-t1x9gknd 11716 9 products product NNS cord-010119-t1x9gknd 11716 10 . . . cord-010119-t1x9gknd 11717 1 As as IN cord-010119-t1x9gknd 11717 2 platelet platelet NN cord-010119-t1x9gknd 11717 3 usage usage NN cord-010119-t1x9gknd 11717 4 can can MD cord-010119-t1x9gknd 11717 5 vary vary VB cord-010119-t1x9gknd 11717 6 widely widely RB cord-010119-t1x9gknd 11717 7 day day NN cord-010119-t1x9gknd 11717 8 to to IN cord-010119-t1x9gknd 11717 9 day day NN cord-010119-t1x9gknd 11717 10 platelet platelet NN cord-010119-t1x9gknd 11717 11 usage usage NN cord-010119-t1x9gknd 11717 12 projections projection NNS cord-010119-t1x9gknd 11717 13 are be VBP cord-010119-t1x9gknd 11717 14 provided provide VBN cord-010119-t1x9gknd 11717 15 to to IN cord-010119-t1x9gknd 11717 16 KBC KBC NNP cord-010119-t1x9gknd 11717 17 by by IN cord-010119-t1x9gknd 11717 18 the the DT cord-010119-t1x9gknd 11717 19 UKMC UKMC NNP cord-010119-t1x9gknd 11717 20 blood blood NN cord-010119-t1x9gknd 11717 21 bank bank NN cord-010119-t1x9gknd 11717 22 , , , cord-010119-t1x9gknd 11717 23 thereby thereby RB cord-010119-t1x9gknd 11717 24 allowing allow VBG cord-010119-t1x9gknd 11717 25 KBC KBC NNP cord-010119-t1x9gknd 11717 26 to to TO cord-010119-t1x9gknd 11717 27 act act VB cord-010119-t1x9gknd 11717 28 accordingly accordingly RB cord-010119-t1x9gknd 11717 29 with with IN cord-010119-t1x9gknd 11717 30 a a DT cord-010119-t1x9gknd 11717 31 given give VBN cord-010119-t1x9gknd 11717 32 day day NN cord-010119-t1x9gknd 11717 33 's 's POS cord-010119-t1x9gknd 11717 34 stock stock NN cord-010119-t1x9gknd 11717 35 ( ( -LRB- cord-010119-t1x9gknd 11717 36 i.e. i.e. FW cord-010119-t1x9gknd 11717 37 import import NN cord-010119-t1x9gknd 11717 38 vs vs IN cord-010119-t1x9gknd 11717 39 export export NN cord-010119-t1x9gknd 11717 40 ) ) -RRB- cord-010119-t1x9gknd 11717 41 . . . cord-010119-t1x9gknd 11718 1 Daily daily JJ cord-010119-t1x9gknd 11718 2 platelet platelet NN cord-010119-t1x9gknd 11718 3 projections projection NNS cord-010119-t1x9gknd 11718 4 are be VBP cord-010119-t1x9gknd 11718 5 based base VBN cord-010119-t1x9gknd 11718 6 on on IN cord-010119-t1x9gknd 11718 7 phone phone NN cord-010119-t1x9gknd 11718 8 calls call NNS cord-010119-t1x9gknd 11718 9 asking ask VBG cord-010119-t1x9gknd 11718 10 clinicians clinician NNS cord-010119-t1x9gknd 11718 11 working work VBG cord-010119-t1x9gknd 11718 12 in in IN cord-010119-t1x9gknd 11718 13 high high JJ cord-010119-t1x9gknd 11718 14 - - HYPH cord-010119-t1x9gknd 11718 15 demand demand NN cord-010119-t1x9gknd 11718 16 locations location NNS cord-010119-t1x9gknd 11718 17 to to TO cord-010119-t1x9gknd 11718 18 estimate estimate VB cord-010119-t1x9gknd 11718 19 their -PRON- PRP$ cord-010119-t1x9gknd 11718 20 needs need NNS cord-010119-t1x9gknd 11718 21 . . . cord-010119-t1x9gknd 11719 1 This this DT cord-010119-t1x9gknd 11719 2 process process NN cord-010119-t1x9gknd 11719 3 can can MD cord-010119-t1x9gknd 11719 4 be be VB cord-010119-t1x9gknd 11719 5 easily easily RB cord-010119-t1x9gknd 11719 6 confounded confound VBN cord-010119-t1x9gknd 11719 7 by by IN cord-010119-t1x9gknd 11719 8 multiple multiple JJ cord-010119-t1x9gknd 11719 9 factors factor NNS cord-010119-t1x9gknd 11719 10 and and CC cord-010119-t1x9gknd 11719 11 has have VBZ cord-010119-t1x9gknd 11719 12 undergone undergo VBN cord-010119-t1x9gknd 11719 13 multiple multiple JJ cord-010119-t1x9gknd 11719 14 adjustments adjustment NNS cord-010119-t1x9gknd 11719 15 to to TO cord-010119-t1x9gknd 11719 16 improve improve VB cord-010119-t1x9gknd 11719 17 its -PRON- PRP$ cord-010119-t1x9gknd 11719 18 accuracy accuracy NN cord-010119-t1x9gknd 11719 19 . . . cord-010119-t1x9gknd 11720 1 Study Study NNP cord-010119-t1x9gknd 11720 2 Design Design NNP cord-010119-t1x9gknd 11720 3 / / SYM cord-010119-t1x9gknd 11720 4 Method Method NNP cord-010119-t1x9gknd 11720 5 : : : cord-010119-t1x9gknd 11720 6 Daily daily JJ cord-010119-t1x9gknd 11720 7 platelet platelet NN cord-010119-t1x9gknd 11720 8 projection projection NN cord-010119-t1x9gknd 11720 9 forms form NNS cord-010119-t1x9gknd 11720 10 from from IN cord-010119-t1x9gknd 11720 11 9/16 9/16 CD cord-010119-t1x9gknd 11720 12 - - HYPH cord-010119-t1x9gknd 11720 13 12/16 12/16 CD cord-010119-t1x9gknd 11720 14 were be VBD cord-010119-t1x9gknd 11720 15 retrospectively retrospectively RB cord-010119-t1x9gknd 11720 16 reviewed review VBN cord-010119-t1x9gknd 11720 17 and and CC cord-010119-t1x9gknd 11720 18 compared compare VBN cord-010119-t1x9gknd 11720 19 to to IN cord-010119-t1x9gknd 11720 20 actual actual JJ cord-010119-t1x9gknd 11720 21 usage usage NN cord-010119-t1x9gknd 11720 22 data datum NNS cord-010119-t1x9gknd 11720 23 over over IN cord-010119-t1x9gknd 11720 24 that that DT cord-010119-t1x9gknd 11720 25 same same JJ cord-010119-t1x9gknd 11720 26 time time NN cord-010119-t1x9gknd 11720 27 . . . cord-010119-t1x9gknd 11721 1 The the DT cord-010119-t1x9gknd 11721 2 prediction prediction NN cord-010119-t1x9gknd 11721 3 system system NN cord-010119-t1x9gknd 11721 4 used use VBN cord-010119-t1x9gknd 11721 5 in in IN cord-010119-t1x9gknd 11721 6 the the DT cord-010119-t1x9gknd 11721 7 UKMC UKMC NNP cord-010119-t1x9gknd 11721 8 BB BB NNP cord-010119-t1x9gknd 11721 9 up up RP cord-010119-t1x9gknd 11721 10 to to IN cord-010119-t1x9gknd 11721 11 that that DT cord-010119-t1x9gknd 11721 12 time time NN cord-010119-t1x9gknd 11721 13 ( ( -LRB- cord-010119-t1x9gknd 11721 14 estimated estimate VBN cord-010119-t1x9gknd 11721 15 clinical clinical JJ cord-010119-t1x9gknd 11721 16 need need NN cord-010119-t1x9gknd 11721 17 1 1 CD cord-010119-t1x9gknd 11721 18 6 6 CD cord-010119-t1x9gknd 11721 19 ) ) -RRB- cord-010119-t1x9gknd 11721 20 was be VBD cord-010119-t1x9gknd 11721 21 evaluated evaluate VBN cord-010119-t1x9gknd 11721 22 for for IN cord-010119-t1x9gknd 11721 23 effectiveness effectiveness NN cord-010119-t1x9gknd 11721 24 based base VBN cord-010119-t1x9gknd 11721 25 on on IN cord-010119-t1x9gknd 11721 26 : : : cord-010119-t1x9gknd 11721 27 total total JJ cord-010119-t1x9gknd 11721 28 number number NN cord-010119-t1x9gknd 11721 29 of of IN cord-010119-t1x9gknd 11721 30 days day NNS cord-010119-t1x9gknd 11721 31 under under RB cord-010119-t1x9gknd 11721 32 - - HYPH cord-010119-t1x9gknd 11721 33 predicted predict VBN cord-010119-t1x9gknd 11721 34 , , , cord-010119-t1x9gknd 11721 35 number number NN cord-010119-t1x9gknd 11721 36 of of IN cord-010119-t1x9gknd 11721 37 days day NNS cord-010119-t1x9gknd 11721 38 with with IN cord-010119-t1x9gknd 11721 39 large large JJ cord-010119-t1x9gknd 11721 40 underprediction underprediction NN cord-010119-t1x9gknd 11721 41 , , , cord-010119-t1x9gknd 11721 42 average average JJ cord-010119-t1x9gknd 11721 43 number number NN cord-010119-t1x9gknd 11721 44 of of IN cord-010119-t1x9gknd 11721 45 units unit NNS cord-010119-t1x9gknd 11721 46 under under RB cord-010119-t1x9gknd 11721 47 - - HYPH cord-010119-t1x9gknd 11721 48 predicted predict VBN cord-010119-t1x9gknd 11721 49 , , , cord-010119-t1x9gknd 11721 50 and and CC cord-010119-t1x9gknd 11721 51 average average JJ cord-010119-t1x9gknd 11721 52 difference difference NN cord-010119-t1x9gknd 11721 53 between between IN cord-010119-t1x9gknd 11721 54 prediction prediction NN cord-010119-t1x9gknd 11721 55 and and CC cord-010119-t1x9gknd 11721 56 usage usage NN cord-010119-t1x9gknd 11721 57 . . . cord-010119-t1x9gknd 11722 1 The the DT cord-010119-t1x9gknd 11722 2 prediction prediction NN cord-010119-t1x9gknd 11722 3 system system NN cord-010119-t1x9gknd 11722 4 was be VBD cord-010119-t1x9gknd 11722 5 subsequently subsequently RB cord-010119-t1x9gknd 11722 6 changed change VBN cord-010119-t1x9gknd 11722 7 based base VBN cord-010119-t1x9gknd 11722 8 on on IN cord-010119-t1x9gknd 11722 9 this this DT cord-010119-t1x9gknd 11722 10 data data NN cord-010119-t1x9gknd 11722 11 in in IN cord-010119-t1x9gknd 11722 12 2017 2017 CD cord-010119-t1x9gknd 11722 13 ; ; : cord-010119-t1x9gknd 11722 14 the the DT cord-010119-t1x9gknd 11722 15 revised revised JJ cord-010119-t1x9gknd 11722 16 prediction prediction NN cord-010119-t1x9gknd 11722 17 method method NN cord-010119-t1x9gknd 11722 18 ( ( -LRB- cord-010119-t1x9gknd 11722 19 estimated estimate VBN cord-010119-t1x9gknd 11722 20 clinical clinical JJ cord-010119-t1x9gknd 11722 21 need need NN cord-010119-t1x9gknd 11722 22 1 1 CD cord-010119-t1x9gknd 11722 23 11 11 CD cord-010119-t1x9gknd 11722 24 ) ) -RRB- cord-010119-t1x9gknd 11722 25 was be VBD cord-010119-t1x9gknd 11722 26 then then RB cord-010119-t1x9gknd 11722 27 evaluated evaluate VBN cord-010119-t1x9gknd 11722 28 retrospectively retrospectively RB cord-010119-t1x9gknd 11722 29 using use VBG cord-010119-t1x9gknd 11722 30 the the DT cord-010119-t1x9gknd 11722 31 same same JJ cord-010119-t1x9gknd 11722 32 data datum NNS cord-010119-t1x9gknd 11722 33 sources source NNS cord-010119-t1x9gknd 11722 34 covering cover VBG cord-010119-t1x9gknd 11722 35 1/17 1/17 CD cord-010119-t1x9gknd 11722 36 - - SYM cord-010119-t1x9gknd 11722 37 4/17 4/17 CD cord-010119-t1x9gknd 11722 38 and and CC cord-010119-t1x9gknd 11722 39 then then RB cord-010119-t1x9gknd 11722 40 compared compare VBN cord-010119-t1x9gknd 11722 41 to to IN cord-010119-t1x9gknd 11722 42 the the DT cord-010119-t1x9gknd 11722 43 prior prior JJ cord-010119-t1x9gknd 11722 44 method method NN cord-010119-t1x9gknd 11722 45 . . . cord-010119-t1x9gknd 11723 1 Results/ Results/ . cord-010119-t1x9gknd 11724 1 Finding finding NN cord-010119-t1x9gknd 11724 2 : : : cord-010119-t1x9gknd 11725 1 The the DT cord-010119-t1x9gknd 11725 2 average average JJ cord-010119-t1x9gknd 11725 3 number number NN cord-010119-t1x9gknd 11725 4 of of IN cord-010119-t1x9gknd 11725 5 platelets platelet NNS cord-010119-t1x9gknd 11725 6 transfused transfuse VBN cord-010119-t1x9gknd 11725 7 from from IN cord-010119-t1x9gknd 11725 8 9/16 9/16 CD cord-010119-t1x9gknd 11725 9 - - HYPH cord-010119-t1x9gknd 11725 10 12/ 12/ CD cord-010119-t1x9gknd 11725 11 16 16 CD cord-010119-t1x9gknd 11725 12 was be VBD cord-010119-t1x9gknd 11725 13 18.2 18.2 CD cord-010119-t1x9gknd 11725 14 U U NNP cord-010119-t1x9gknd 11725 15 / / SYM cord-010119-t1x9gknd 11725 16 d d XX cord-010119-t1x9gknd 11725 17 with with IN cord-010119-t1x9gknd 11725 18 a a DT cord-010119-t1x9gknd 11725 19 standard standard JJ cord-010119-t1x9gknd 11725 20 deviation deviation NN cord-010119-t1x9gknd 11725 21 of of IN cord-010119-t1x9gknd 11725 22 5.3 5.3 CD cord-010119-t1x9gknd 11725 23 U u NN cord-010119-t1x9gknd 11725 24 / / SYM cord-010119-t1x9gknd 11725 25 d d XX cord-010119-t1x9gknd 11725 26 ; ; : cord-010119-t1x9gknd 11725 27 the the DT cord-010119-t1x9gknd 11725 28 predicted predict VBN cord-010119-t1x9gknd 11725 29 amount amount NN cord-010119-t1x9gknd 11725 30 was be VBD cord-010119-t1x9gknd 11725 31 13.7 13.7 CD cord-010119-t1x9gknd 11725 32 U u NN cord-010119-t1x9gknd 11725 33 / / SYM cord-010119-t1x9gknd 11725 34 d d NN cord-010119-t1x9gknd 11725 35 . . . cord-010119-t1x9gknd 11726 1 The the DT cord-010119-t1x9gknd 11726 2 difference difference NN cord-010119-t1x9gknd 11726 3 between between IN cord-010119-t1x9gknd 11726 4 the the DT cord-010119-t1x9gknd 11726 5 predicted predict VBN cord-010119-t1x9gknd 11726 6 amount amount NN cord-010119-t1x9gknd 11726 7 and and CC cord-010119-t1x9gknd 11726 8 the the DT cord-010119-t1x9gknd 11726 9 number number NN cord-010119-t1x9gknd 11726 10 of of IN cord-010119-t1x9gknd 11726 11 units unit NNS cord-010119-t1x9gknd 11726 12 used use VBN cord-010119-t1x9gknd 11726 13 was be VBD cord-010119-t1x9gknd 11726 14 -4.5 -4.5 NNP cord-010119-t1x9gknd 11726 15 U U NNP cord-010119-t1x9gknd 11726 16 / / SYM cord-010119-t1x9gknd 11726 17 d d NN cord-010119-t1x9gknd 11726 18 . . . cord-010119-t1x9gknd 11726 19 79 79 CD cord-010119-t1x9gknd 11726 20 % % NN cord-010119-t1x9gknd 11726 21 days day NNS cord-010119-t1x9gknd 11726 22 ( ( -LRB- cord-010119-t1x9gknd 11726 23 23d 23d NNS cord-010119-t1x9gknd 11726 24 / / SYM cord-010119-t1x9gknd 11726 25 month month NN cord-010119-t1x9gknd 11726 26 ) ) -RRB- cord-010119-t1x9gknd 11726 27 were be VBD cord-010119-t1x9gknd 11726 28 under under RB cord-010119-t1x9gknd 11726 29 - - HYPH cord-010119-t1x9gknd 11726 30 predicted predict VBN cord-010119-t1x9gknd 11726 31 ( ( -LRB- cord-010119-t1x9gknd 11726 32 average average NN cord-010119-t1x9gknd 11726 33 : : : cord-010119-t1x9gknd 11726 34 6 6 CD cord-010119-t1x9gknd 11726 35 U u NN cord-010119-t1x9gknd 11726 36 / / SYM cord-010119-t1x9gknd 11726 37 d d NN cord-010119-t1x9gknd 11726 38 ) ) -RRB- cord-010119-t1x9gknd 11726 39 . . . cord-010119-t1x9gknd 11727 1 17 17 CD cord-010119-t1x9gknd 11727 2 % % NN cord-010119-t1x9gknd 11727 3 of of IN cord-010119-t1x9gknd 11727 4 days day NNS cord-010119-t1x9gknd 11727 5 ( ( -LRB- cord-010119-t1x9gknd 11727 6 10 10 CD cord-010119-t1x9gknd 11727 7 ) ) -RRB- cord-010119-t1x9gknd 11727 8 were be VBD cord-010119-t1x9gknd 11727 9 under under RB cord-010119-t1x9gknd 11727 10 - - HYPH cord-010119-t1x9gknd 11727 11 predicted predict VBN cord-010119-t1x9gknd 11727 12 by by IN cord-010119-t1x9gknd 11727 13 ! ! . cord-010119-t1x9gknd 11728 1 10 10 CD cord-010119-t1x9gknd 11728 2 U u NN cord-010119-t1x9gknd 11728 3 ( ( -LRB- cord-010119-t1x9gknd 11728 4 average average NN cord-010119-t1x9gknd 11728 5 : : : cord-010119-t1x9gknd 11728 6 12 12 CD cord-010119-t1x9gknd 11728 7 U u NN cord-010119-t1x9gknd 11728 8 ; ; : cord-010119-t1x9gknd 11728 9 max max NN cord-010119-t1x9gknd 11728 10 : : : cord-010119-t1x9gknd 11728 11 15 15 CD cord-010119-t1x9gknd 11728 12 U u NN cord-010119-t1x9gknd 11728 13 ( ( -LRB- cord-010119-t1x9gknd 11728 14 4x 4x CD cord-010119-t1x9gknd 11728 15 ) ) -RRB- cord-010119-t1x9gknd 11728 16 ) ) -RRB- cord-010119-t1x9gknd 11728 17 . . . cord-010119-t1x9gknd 11729 1 The the DT cord-010119-t1x9gknd 11729 2 average average JJ cord-010119-t1x9gknd 11729 3 number number NN cord-010119-t1x9gknd 11729 4 of of IN cord-010119-t1x9gknd 11729 5 platelets platelet NNS cord-010119-t1x9gknd 11729 6 used use VBN cord-010119-t1x9gknd 11729 7 from from IN cord-010119-t1x9gknd 11729 8 1/17 1/17 CD cord-010119-t1x9gknd 11729 9 - - SYM cord-010119-t1x9gknd 11729 10 4/17 4/17 CD cord-010119-t1x9gknd 11729 11 was be VBD cord-010119-t1x9gknd 11729 12 17.5 17.5 CD cord-010119-t1x9gknd 11729 13 U u NN cord-010119-t1x9gknd 11729 14 / / SYM cord-010119-t1x9gknd 11729 15 d d XX cord-010119-t1x9gknd 11729 16 with with IN cord-010119-t1x9gknd 11729 17 a a DT cord-010119-t1x9gknd 11729 18 standard standard JJ cord-010119-t1x9gknd 11729 19 deviation deviation NN cord-010119-t1x9gknd 11729 20 of of IN cord-010119-t1x9gknd 11729 21 4.4 4.4 CD cord-010119-t1x9gknd 11729 22 U u NN cord-010119-t1x9gknd 11729 23 / / SYM cord-010119-t1x9gknd 11729 24 d d XX cord-010119-t1x9gknd 11729 25 ; ; : cord-010119-t1x9gknd 11729 26 the the DT cord-010119-t1x9gknd 11729 27 predicted predict VBN cord-010119-t1x9gknd 11729 28 amount amount NN cord-010119-t1x9gknd 11729 29 was be VBD cord-010119-t1x9gknd 11729 30 18.3 18.3 CD cord-010119-t1x9gknd 11729 31 U U NNP cord-010119-t1x9gknd 11729 32 / / SYM cord-010119-t1x9gknd 11729 33 d d NN cord-010119-t1x9gknd 11729 34 . . . cord-010119-t1x9gknd 11730 1 The the DT cord-010119-t1x9gknd 11730 2 difference difference NN cord-010119-t1x9gknd 11730 3 between between IN cord-010119-t1x9gknd 11730 4 the the DT cord-010119-t1x9gknd 11730 5 predicted predict VBN cord-010119-t1x9gknd 11730 6 and and CC cord-010119-t1x9gknd 11730 7 units unit NNS cord-010119-t1x9gknd 11730 8 used use VBN cord-010119-t1x9gknd 11730 9 was be VBD cord-010119-t1x9gknd 11730 10 a a DT cord-010119-t1x9gknd 11730 11 10.8 10.8 CD cord-010119-t1x9gknd 11730 12 U u NN cord-010119-t1x9gknd 11730 13 / / SYM cord-010119-t1x9gknd 11730 14 d d NN cord-010119-t1x9gknd 11730 15 . . . cord-010119-t1x9gknd 11731 1 38 38 CD cord-010119-t1x9gknd 11731 2 % % NN cord-010119-t1x9gknd 11731 3 days day NNS cord-010119-t1x9gknd 11731 4 ( ( -LRB- cord-010119-t1x9gknd 11731 5 11d/ 11d/ CD cord-010119-t1x9gknd 11731 6 month month NN cord-010119-t1x9gknd 11731 7 ) ) -RRB- cord-010119-t1x9gknd 11731 8 were be VBD cord-010119-t1x9gknd 11731 9 under under RB cord-010119-t1x9gknd 11731 10 - - HYPH cord-010119-t1x9gknd 11731 11 predicted predict VBN cord-010119-t1x9gknd 11731 12 ( ( -LRB- cord-010119-t1x9gknd 11731 13 average average NN cord-010119-t1x9gknd 11731 14 : : : cord-010119-t1x9gknd 11731 15 3.5 3.5 CD cord-010119-t1x9gknd 11731 16 U u NN cord-010119-t1x9gknd 11731 17 / / SYM cord-010119-t1x9gknd 11731 18 d d NN cord-010119-t1x9gknd 11731 19 ) ) -RRB- cord-010119-t1x9gknd 11731 20 . . . cord-010119-t1x9gknd 11732 1 One one CD cord-010119-t1x9gknd 11732 2 day day NN cord-010119-t1x9gknd 11732 3 ( ( -LRB- cord-010119-t1x9gknd 11732 4 1 1 CD cord-010119-t1x9gknd 11732 5 % % NN cord-010119-t1x9gknd 11732 6 ) ) -RRB- cord-010119-t1x9gknd 11732 7 over over IN cord-010119-t1x9gknd 11732 8 this this DT cord-010119-t1x9gknd 11732 9 period period NN cord-010119-t1x9gknd 11732 10 was be VBD cord-010119-t1x9gknd 11732 11 under under RB cord-010119-t1x9gknd 11732 12 - - HYPH cord-010119-t1x9gknd 11732 13 predicted predict VBN cord-010119-t1x9gknd 11732 14 ! ! . cord-010119-t1x9gknd 11733 1 10 10 CD cord-010119-t1x9gknd 11733 2 U u NN cord-010119-t1x9gknd 11733 3 ( ( -LRB- cord-010119-t1x9gknd 11733 4 11 11 CD cord-010119-t1x9gknd 11733 5 U U NNP cord-010119-t1x9gknd 11733 6 ) ) -RRB- cord-010119-t1x9gknd 11733 7 . . . cord-010119-t1x9gknd 11734 1 Conclusion conclusion NN cord-010119-t1x9gknd 11734 2 : : : cord-010119-t1x9gknd 11734 3 Review Review NNP cord-010119-t1x9gknd 11734 4 of of IN cord-010119-t1x9gknd 11734 5 clinical clinical JJ cord-010119-t1x9gknd 11734 6 platelet platelet NN cord-010119-t1x9gknd 11734 7 usage usage NN cord-010119-t1x9gknd 11734 8 over over IN cord-010119-t1x9gknd 11734 9 this this DT cord-010119-t1x9gknd 11734 10 time time NN cord-010119-t1x9gknd 11734 11 identified identify VBD cord-010119-t1x9gknd 11734 12 a a DT cord-010119-t1x9gknd 11734 13 relatively relatively RB cord-010119-t1x9gknd 11734 14 stable stable JJ cord-010119-t1x9gknd 11734 15 average average JJ cord-010119-t1x9gknd 11734 16 daily daily JJ cord-010119-t1x9gknd 11734 17 clinical clinical JJ cord-010119-t1x9gknd 11734 18 demand demand NN cord-010119-t1x9gknd 11734 19 . . . cord-010119-t1x9gknd 11735 1 Adjustment adjustment NN cord-010119-t1x9gknd 11735 2 of of IN cord-010119-t1x9gknd 11735 3 our -PRON- PRP$ cord-010119-t1x9gknd 11735 4 prediction prediction NN cord-010119-t1x9gknd 11735 5 system system NN cord-010119-t1x9gknd 11735 6 to to TO cord-010119-t1x9gknd 11735 7 ensure ensure VB cord-010119-t1x9gknd 11735 8 that that IN cord-010119-t1x9gknd 11735 9 no no UH cord-010119-t1x9gknd 11735 10 , , , cord-010119-t1x9gknd 11735 11 or or CC cord-010119-t1x9gknd 11735 12 as as RB cord-010119-t1x9gknd 11735 13 few few JJ cord-010119-t1x9gknd 11735 14 as as IN cord-010119-t1x9gknd 11735 15 possible possible JJ cord-010119-t1x9gknd 11735 16 , , , cord-010119-t1x9gknd 11735 17 days day NNS cord-010119-t1x9gknd 11735 18 were be VBD cord-010119-t1x9gknd 11735 19 projected project VBN cord-010119-t1x9gknd 11735 20 for for IN cord-010119-t1x9gknd 11735 21 less less JJR cord-010119-t1x9gknd 11735 22 than than IN cord-010119-t1x9gknd 11735 23 that that DT cord-010119-t1x9gknd 11735 24 average average NN cord-010119-t1x9gknd 11735 25 has have VBZ cord-010119-t1x9gknd 11735 26 markedly markedly RB cord-010119-t1x9gknd 11735 27 reduced reduce VBN cord-010119-t1x9gknd 11735 28 catastrophic catastrophic JJ cord-010119-t1x9gknd 11735 29 shortages shortage NNS cord-010119-t1x9gknd 11735 30 ( ( -LRB- cord-010119-t1x9gknd 11735 31 17 17 CD cord-010119-t1x9gknd 11735 32 % % NN cord-010119-t1x9gknd 11735 33 a a DT cord-010119-t1x9gknd 11735 34 1 1 CD cord-010119-t1x9gknd 11735 35 % % NN cord-010119-t1x9gknd 11735 36 ) ) -RRB- cord-010119-t1x9gknd 11735 37 , , , cord-010119-t1x9gknd 11735 38 reduced reduce VBD cord-010119-t1x9gknd 11735 39 the the DT cord-010119-t1x9gknd 11735 40 number number NN cord-010119-t1x9gknd 11735 41 of of IN cord-010119-t1x9gknd 11735 42 days day NNS cord-010119-t1x9gknd 11735 43 under under RB cord-010119-t1x9gknd 11735 44 - - HYPH cord-010119-t1x9gknd 11735 45 predicted predict VBN cord-010119-t1x9gknd 11735 46 ( ( -LRB- cord-010119-t1x9gknd 11735 47 79 79 CD cord-010119-t1x9gknd 11735 48 % % NN cord-010119-t1x9gknd 11735 49 a a DT cord-010119-t1x9gknd 11735 50 38 38 CD cord-010119-t1x9gknd 11735 51 % % NN cord-010119-t1x9gknd 11735 52 ) ) -RRB- cord-010119-t1x9gknd 11735 53 , , , cord-010119-t1x9gknd 11735 54 and and CC cord-010119-t1x9gknd 11735 55 decreased decrease VBD cord-010119-t1x9gknd 11735 56 the the DT cord-010119-t1x9gknd 11735 57 discrepancy discrepancy NN cord-010119-t1x9gknd 11735 58 on on IN cord-010119-t1x9gknd 11735 59 those those DT cord-010119-t1x9gknd 11735 60 under under RB cord-010119-t1x9gknd 11735 61 - - HYPH cord-010119-t1x9gknd 11735 62 predicted predict VBN cord-010119-t1x9gknd 11735 63 days day NNS cord-010119-t1x9gknd 11735 64 ( ( -LRB- cord-010119-t1x9gknd 11735 65 5.9 5.9 CD cord-010119-t1x9gknd 11735 66 U u NN cord-010119-t1x9gknd 11735 67 a a DT cord-010119-t1x9gknd 11735 68 3.5 3.5 CD cord-010119-t1x9gknd 11735 69 U u NN cord-010119-t1x9gknd 11735 70 ) ) -RRB- cord-010119-t1x9gknd 11735 71 . . . cord-010119-t1x9gknd 11736 1 These these DT cord-010119-t1x9gknd 11736 2 improvements improvement NNS cord-010119-t1x9gknd 11736 3 in in IN cord-010119-t1x9gknd 11736 4 estimating estimate VBG cord-010119-t1x9gknd 11736 5 usage usage NN cord-010119-t1x9gknd 11736 6 allow allow VBP cord-010119-t1x9gknd 11736 7 for for IN cord-010119-t1x9gknd 11736 8 an an DT cord-010119-t1x9gknd 11736 9 increased increase VBN cord-010119-t1x9gknd 11736 10 ability ability NN cord-010119-t1x9gknd 11736 11 to to TO cord-010119-t1x9gknd 11736 12 handle handle VB cord-010119-t1x9gknd 11736 13 unpredictable unpredictable JJ cord-010119-t1x9gknd 11736 14 events event NNS cord-010119-t1x9gknd 11736 15 without without IN cord-010119-t1x9gknd 11736 16 suddenly suddenly RB cord-010119-t1x9gknd 11736 17 straining strain VBG cord-010119-t1x9gknd 11736 18 KBC KBC NNP cord-010119-t1x9gknd 11736 19 's 's POS cord-010119-t1x9gknd 11736 20 supply supply NN cord-010119-t1x9gknd 11736 21 flexibility flexibility NN cord-010119-t1x9gknd 11736 22 or or CC cord-010119-t1x9gknd 11736 23 severely severely RB cord-010119-t1x9gknd 11736 24 limiting limit VBG cord-010119-t1x9gknd 11736 25 UKMC UKMC NNP cord-010119-t1x9gknd 11736 26 clinical clinical JJ cord-010119-t1x9gknd 11736 27 settings setting NNS cord-010119-t1x9gknd 11736 28 . . . cord-010119-t1x9gknd 11737 1 Rapid rapid JJ cord-010119-t1x9gknd 11737 2 Implementation Implementation NNP cord-010119-t1x9gknd 11737 3 of of IN cord-010119-t1x9gknd 11737 4 Zika Zika NNP cord-010119-t1x9gknd 11737 5 Virus Virus NNP cord-010119-t1x9gknd 11737 6 ( ( -LRB- cord-010119-t1x9gknd 11737 7 ZKV zkv NN cord-010119-t1x9gknd 11737 8 ) ) -RRB- cord-010119-t1x9gknd 11738 1 NAT NAT NNP cord-010119-t1x9gknd 11738 2 Blood Blood NNP cord-010119-t1x9gknd 11738 3 Donor Donor NNP cord-010119-t1x9gknd 11738 4 Screening screening NN cord-010119-t1x9gknd 11739 1 Joan Joan NNP cord-010119-t1x9gknd 11739 2 Dunn Dunn NNP cord-010119-t1x9gknd 11739 3 Williams Williams NNP cord-010119-t1x9gknd 11740 1 * * NFP cord-010119-t1x9gknd 11740 2 1 1 CD cord-010119-t1x9gknd 11740 3 , , , cord-010119-t1x9gknd 11740 4 Maria Maria NNP cord-010119-t1x9gknd 11740 5 Noedel Noedel NNP cord-010119-t1x9gknd 11740 6 1 1 CD cord-010119-t1x9gknd 11741 1 , , , cord-010119-t1x9gknd 11741 2 Nancy Nancy NNP cord-010119-t1x9gknd 11741 3 Haubert Haubert NNP cord-010119-t1x9gknd 11741 4 1 1 CD cord-010119-t1x9gknd 11741 5 , , , cord-010119-t1x9gknd 11741 6 Kenneth Kenneth NNP cord-010119-t1x9gknd 11741 7 Hudson Hudson NNP cord-010119-t1x9gknd 11741 8 1 1 CD cord-010119-t1x9gknd 11741 9 , , , cord-010119-t1x9gknd 11741 10 Larry Larry NNP cord-010119-t1x9gknd 11741 11 Morgan Morgan NNP cord-010119-t1x9gknd 11741 12 1 1 CD cord-010119-t1x9gknd 11741 13 , , , cord-010119-t1x9gknd 11741 14 Robert Robert NNP cord-010119-t1x9gknd 11741 15 Shaw Shaw NNP cord-010119-t1x9gknd 11741 16 1 1 CD cord-010119-t1x9gknd 11741 17 , , , cord-010119-t1x9gknd 11741 18 Tracy Tracy NNP cord-010119-t1x9gknd 11741 19 Fickett Fickett NNP cord-010119-t1x9gknd 11741 20 1 1 CD cord-010119-t1x9gknd 11741 21 , , , cord-010119-t1x9gknd 11741 22 Jamie Jamie NNP cord-010119-t1x9gknd 11741 23 Jue Jue NNP cord-010119-t1x9gknd 11741 24 1 1 CD cord-010119-t1x9gknd 11741 25 , , , cord-010119-t1x9gknd 11741 26 Valerie Valerie NNP cord-010119-t1x9gknd 11741 27 Winkelman Winkelman NNP cord-010119-t1x9gknd 11741 28 1 1 CD cord-010119-t1x9gknd 11741 29 , , , cord-010119-t1x9gknd 11741 30 Sally Sally NNP cord-010119-t1x9gknd 11741 31 Caglioti Caglioti NNP cord-010119-t1x9gknd 11741 32 1 1 CD cord-010119-t1x9gknd 11741 33 , , , cord-010119-t1x9gknd 11741 34 German German NNP cord-010119-t1x9gknd 11741 35 Leparc Leparc NNP cord-010119-t1x9gknd 11741 36 2,3 2,3 CD cord-010119-t1x9gknd 11741 37 and and CC cord-010119-t1x9gknd 11741 38 Phillip Phillip NNP cord-010119-t1x9gknd 11741 39 C C NNP cord-010119-t1x9gknd 11741 40 Williamson Williamson NNP cord-010119-t1x9gknd 11741 41 1 1 CD cord-010119-t1x9gknd 11741 42 . . . cord-010119-t1x9gknd 11742 1 Background Background NNP cord-010119-t1x9gknd 11742 2 / / SYM cord-010119-t1x9gknd 11742 3 Case Case NNP cord-010119-t1x9gknd 11742 4 Studies Studies NNPS cord-010119-t1x9gknd 11742 5 : : : cord-010119-t1x9gknd 11742 6 On on IN cord-010119-t1x9gknd 11742 7 08/26/16 08/26/16 CD cord-010119-t1x9gknd 11742 8 , , , cord-010119-t1x9gknd 11742 9 FDA FDA NNP cord-010119-t1x9gknd 11742 10 issued issue VBD cord-010119-t1x9gknd 11742 11 a a DT cord-010119-t1x9gknd 11742 12 guidance guidance NN cord-010119-t1x9gknd 11742 13 document document NN cord-010119-t1x9gknd 11742 14 for for IN cord-010119-t1x9gknd 11742 15 " " `` cord-010119-t1x9gknd 11742 16 Reducing reduce VBG cord-010119-t1x9gknd 11742 17 the the DT cord-010119-t1x9gknd 11742 18 Risk Risk NNP cord-010119-t1x9gknd 11742 19 of of IN cord-010119-t1x9gknd 11742 20 ZKV ZKV NNP cord-010119-t1x9gknd 11742 21 Transmission Transmission NNP cord-010119-t1x9gknd 11742 22 by by IN cord-010119-t1x9gknd 11742 23 Blood blood NN cord-010119-t1x9gknd 11742 24 and and CC cord-010119-t1x9gknd 11742 25 Blood blood NN cord-010119-t1x9gknd 11742 26 Components Components NNP cord-010119-t1x9gknd 11742 27 " " '' cord-010119-t1x9gknd 11742 28 . . . cord-010119-t1x9gknd 11743 1 In in IN cord-010119-t1x9gknd 11743 2 response response NN cord-010119-t1x9gknd 11743 3 , , , cord-010119-t1x9gknd 11743 4 a a DT cord-010119-t1x9gknd 11743 5 plan plan NN cord-010119-t1x9gknd 11743 6 was be VBD cord-010119-t1x9gknd 11743 7 implemented implement VBN cord-010119-t1x9gknd 11743 8 for for IN cord-010119-t1x9gknd 11743 9 mandatory mandatory JJ cord-010119-t1x9gknd 11743 10 ZKV ZKV NNP cord-010119-t1x9gknd 11743 11 testing testing NN cord-010119-t1x9gknd 11743 12 for for IN cord-010119-t1x9gknd 11743 13 all all DT cord-010119-t1x9gknd 11743 14 Clients client NNS cord-010119-t1x9gknd 11743 15 with with IN cord-010119-t1x9gknd 11743 16 locally locally RB cord-010119-t1x9gknd 11743 17 acquired acquire VBN cord-010119-t1x9gknd 11743 18 mosquito mosquito NN cord-010119-t1x9gknd 11743 19 - - HYPH cord-010119-t1x9gknd 11743 20 borne bear VBN cord-010119-t1x9gknd 11743 21 cases case NNS cord-010119-t1x9gknd 11743 22 of of IN cord-010119-t1x9gknd 11743 23 ZKV ZKV NNP cord-010119-t1x9gknd 11743 24 within within IN cord-010119-t1x9gknd 11743 25 4 4 CD cord-010119-t1x9gknd 11743 26 weeks week NNS cord-010119-t1x9gknd 11743 27 ; ; : cord-010119-t1x9gknd 11743 28 nationwide nationwide RB cord-010119-t1x9gknd 11743 29 in in IN cord-010119-t1x9gknd 11743 30 12 12 CD cord-010119-t1x9gknd 11743 31 weeks week NNS cord-010119-t1x9gknd 11743 32 . . . cord-010119-t1x9gknd 11744 1 This this DT cord-010119-t1x9gknd 11744 2 organization organization NN cord-010119-t1x9gknd 11744 3 performs perform VBZ cord-010119-t1x9gknd 11744 4 testing test VBG cord-010119-t1x9gknd 11744 5 for for IN cord-010119-t1x9gknd 11744 6 Clients client NNS cord-010119-t1x9gknd 11744 7 ( ( -LRB- cord-010119-t1x9gknd 11744 8 blood blood NN cord-010119-t1x9gknd 11744 9 centers center NNS cord-010119-t1x9gknd 11744 10 , , , cord-010119-t1x9gknd 11744 11 hospitals hospital NNS cord-010119-t1x9gknd 11744 12 ) ) -RRB- cord-010119-t1x9gknd 11744 13 across across IN cord-010119-t1x9gknd 11744 14 the the DT cord-010119-t1x9gknd 11744 15 country country NN cord-010119-t1x9gknd 11744 16 . . . cord-010119-t1x9gknd 11745 1 We -PRON- PRP cord-010119-t1x9gknd 11745 2 report report VBP cord-010119-t1x9gknd 11745 3 on on IN cord-010119-t1x9gknd 11745 4 1 1 CD cord-010119-t1x9gknd 11745 5 of of IN cord-010119-t1x9gknd 11745 6 2 2 CD cord-010119-t1x9gknd 11745 7 manufacturers manufacturer NNS cord-010119-t1x9gknd 11745 8 ' ' '' cord-010119-t1x9gknd 11745 9 ( ( -LRB- cord-010119-t1x9gknd 11745 10 Sponsor Sponsor NNP cord-010119-t1x9gknd 11745 11 ) ) -RRB- cord-010119-t1x9gknd 11745 12 provided provide VBD cord-010119-t1x9gknd 11745 13 Investigational Investigational NNP cord-010119-t1x9gknd 11745 14 New New NNP cord-010119-t1x9gknd 11745 15 Drug Drug NNP cord-010119-t1x9gknd 11745 16 ( ( -LRB- cord-010119-t1x9gknd 11745 17 IND IND NNP cord-010119-t1x9gknd 11745 18 ) ) -RRB- cord-010119-t1x9gknd 11745 19 protocols protocol NNS cord-010119-t1x9gknd 11745 20 . . . cord-010119-t1x9gknd 11746 1 A a DT cord-010119-t1x9gknd 11746 2 single single JJ cord-010119-t1x9gknd 11746 3 Project Project NNP cord-010119-t1x9gknd 11746 4 Management Management NNP cord-010119-t1x9gknd 11746 5 ( ( -LRB- cord-010119-t1x9gknd 11746 6 PMO PMO NNP cord-010119-t1x9gknd 11746 7 ) ) -RRB- cord-010119-t1x9gknd 11746 8 system system NN cord-010119-t1x9gknd 11746 9 was be VBD cord-010119-t1x9gknd 11746 10 used use VBN cord-010119-t1x9gknd 11746 11 to to TO cord-010119-t1x9gknd 11746 12 control control VB cord-010119-t1x9gknd 11746 13 all all DT cord-010119-t1x9gknd 11746 14 required require VBN cord-010119-t1x9gknd 11746 15 processes process NNS cord-010119-t1x9gknd 11746 16 . . . cord-010119-t1x9gknd 11747 1 Study Study NNP cord-010119-t1x9gknd 11747 2 Design Design NNP cord-010119-t1x9gknd 11747 3 / / SYM cord-010119-t1x9gknd 11747 4 Method Method NNP cord-010119-t1x9gknd 11747 5 : : : cord-010119-t1x9gknd 11747 6 Project Project NNP cord-010119-t1x9gknd 11747 7 focus focus NN cord-010119-t1x9gknd 11747 8 included include VBD cord-010119-t1x9gknd 11747 9 : : : cord-010119-t1x9gknd 11747 10 clinical clinical JJ cord-010119-t1x9gknd 11747 11 trial trial NN cord-010119-t1x9gknd 11747 12 requirements requirement NNS cord-010119-t1x9gknd 11747 13 , , , cord-010119-t1x9gknd 11747 14 Client client NN cord-010119-t1x9gknd 11747 15 onboarding onboarding NN cord-010119-t1x9gknd 11747 16 , , , cord-010119-t1x9gknd 11747 17 lab lab NN cord-010119-t1x9gknd 11747 18 operations operation NNS cord-010119-t1x9gknd 11747 19 ( ( -LRB- cord-010119-t1x9gknd 11747 20 Labs Labs NNP cord-010119-t1x9gknd 11747 21 ) ) -RRB- cord-010119-t1x9gknd 11747 22 . . . cord-010119-t1x9gknd 11748 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11748 2 objectives objective NNS cord-010119-t1x9gknd 11748 3 were be VBD cord-010119-t1x9gknd 11748 4 to to TO cord-010119-t1x9gknd 11748 5 implement implement VB cord-010119-t1x9gknd 11748 6 ZKV ZKV NNP cord-010119-t1x9gknd 11748 7 testing testing NN cord-010119-t1x9gknd 11748 8 for for IN cord-010119-t1x9gknd 11748 9 44 44 CD cord-010119-t1x9gknd 11748 10 Clients client NNS cord-010119-t1x9gknd 11748 11 within within IN cord-010119-t1x9gknd 11748 12 4 4 CD cord-010119-t1x9gknd 11748 13 weeks week NNS cord-010119-t1x9gknd 11748 14 , , , cord-010119-t1x9gknd 11748 15 and and CC cord-010119-t1x9gknd 11748 16 an an DT cord-010119-t1x9gknd 11748 17 additional additional JJ cord-010119-t1x9gknd 11748 18 21 21 CD cord-010119-t1x9gknd 11748 19 Clients client NNS cord-010119-t1x9gknd 11748 20 within within IN cord-010119-t1x9gknd 11748 21 12 12 CD cord-010119-t1x9gknd 11748 22 weeks week NNS cord-010119-t1x9gknd 11748 23 . . . cord-010119-t1x9gknd 11749 1 To to TO cord-010119-t1x9gknd 11749 2 minimize minimize VB cord-010119-t1x9gknd 11749 3 the the DT cord-010119-t1x9gknd 11749 4 impact impact NN cord-010119-t1x9gknd 11749 5 to to IN cord-010119-t1x9gknd 11749 6 Labs lab NNS cord-010119-t1x9gknd 11749 7 a a DT cord-010119-t1x9gknd 11749 8 staggered stagger VBN cord-010119-t1x9gknd 11749 9 implementation implementation NN cord-010119-t1x9gknd 11749 10 was be VBD cord-010119-t1x9gknd 11749 11 used use VBN cord-010119-t1x9gknd 11749 12 with with IN cord-010119-t1x9gknd 11749 13 tracked track VBN cord-010119-t1x9gknd 11749 14 / / SYM cord-010119-t1x9gknd 11749 15 streamlined streamline VBN cord-010119-t1x9gknd 11749 16 communications communication NNS cord-010119-t1x9gknd 11749 17 from from IN cord-010119-t1x9gknd 11749 18 stakeholders stakeholder NNS cord-010119-t1x9gknd 11749 19 : : : cord-010119-t1x9gknd 11749 20 Vendors vendor NNS cord-010119-t1x9gknd 11749 21 , , , cord-010119-t1x9gknd 11749 22 Institutional Institutional NNP cord-010119-t1x9gknd 11749 23 Review Review NNP cord-010119-t1x9gknd 11749 24 Board Board NNP cord-010119-t1x9gknd 11749 25 ( ( -LRB- cord-010119-t1x9gknd 11749 26 IRB IRB NNP cord-010119-t1x9gknd 11749 27 ) ) -RRB- cord-010119-t1x9gknd 11749 28 , , , cord-010119-t1x9gknd 11749 29 IT it PRP cord-010119-t1x9gknd 11749 30 ( ( -LRB- cord-010119-t1x9gknd 11749 31 client client NN cord-010119-t1x9gknd 11749 32 and and CC cord-010119-t1x9gknd 11749 33 lab lab NN cord-010119-t1x9gknd 11749 34 based base VBN cord-010119-t1x9gknd 11749 35 ) ) -RRB- cord-010119-t1x9gknd 11749 36 , , , cord-010119-t1x9gknd 11749 37 Client Client NNP cord-010119-t1x9gknd 11749 38 Services Services NNPS cord-010119-t1x9gknd 11749 39 and and CC cord-010119-t1x9gknd 11749 40 Labs Labs NNPS cord-010119-t1x9gknd 11749 41 . . . cord-010119-t1x9gknd 11750 1 Results/ Results/ . cord-010119-t1x9gknd 11751 1 Finding finding NN cord-010119-t1x9gknd 11751 2 : : : cord-010119-t1x9gknd 11752 1 Clinical clinical JJ cord-010119-t1x9gknd 11752 2 trial trial NN cord-010119-t1x9gknd 11752 3 requirements requirement NNS cord-010119-t1x9gknd 11752 4 increased increase VBD cord-010119-t1x9gknd 11752 5 the the DT cord-010119-t1x9gknd 11752 6 complexity complexity NN cord-010119-t1x9gknd 11752 7 of of IN cord-010119-t1x9gknd 11752 8 implementing implement VBG cord-010119-t1x9gknd 11752 9 an an DT cord-010119-t1x9gknd 11752 10 unlicensed unlicensed JJ cord-010119-t1x9gknd 11752 11 test test NN cord-010119-t1x9gknd 11752 12 . . . cord-010119-t1x9gknd 11753 1 Documents document NNS cord-010119-t1x9gknd 11753 2 included include VBD cord-010119-t1x9gknd 11753 3 donor donor NN cord-010119-t1x9gknd 11753 4 notification notification NN cord-010119-t1x9gknd 11753 5 , , , cord-010119-t1x9gknd 11753 6 informed informed JJ cord-010119-t1x9gknd 11753 7 consent consent NN cord-010119-t1x9gknd 11753 8 , , , cord-010119-t1x9gknd 11753 9 protocol protocol NN cord-010119-t1x9gknd 11753 10 training training NN cord-010119-t1x9gknd 11753 11 , , , cord-010119-t1x9gknd 11753 12 staff staff NN cord-010119-t1x9gknd 11753 13 certification certification NN cord-010119-t1x9gknd 11753 14 , , , cord-010119-t1x9gknd 11753 15 deviation deviation NN cord-010119-t1x9gknd 11753 16 management management NN cord-010119-t1x9gknd 11753 17 , , , cord-010119-t1x9gknd 11753 18 and and CC cord-010119-t1x9gknd 11753 19 result result VB cord-010119-t1x9gknd 11753 20 reporting report VBG cord-010119-t1x9gknd 11753 21 . . . cord-010119-t1x9gknd 11754 1 Multiple multiple JJ cord-010119-t1x9gknd 11754 2 IRB IRB NNP cord-010119-t1x9gknd 11754 3 documents document NNS cord-010119-t1x9gknd 11754 4 were be VBD cord-010119-t1x9gknd 11754 5 required require VBN cord-010119-t1x9gknd 11754 6 . . . cord-010119-t1x9gknd 11755 1 To to TO cord-010119-t1x9gknd 11755 2 ensure ensure VB cord-010119-t1x9gknd 11755 3 accuracy accuracy NN cord-010119-t1x9gknd 11755 4 in in IN cord-010119-t1x9gknd 11755 5 IND IND NNP cord-010119-t1x9gknd 11755 6 commitments commitment NNS cord-010119-t1x9gknd 11755 7 a a DT cord-010119-t1x9gknd 11755 8 Principle Principle NNP cord-010119-t1x9gknd 11755 9 Investigator Investigator NNP cord-010119-t1x9gknd 11755 10 was be VBD cord-010119-t1x9gknd 11755 11 assigned assign VBN cord-010119-t1x9gknd 11755 12 to to IN cord-010119-t1x9gknd 11755 13 Labs Labs NNP cord-010119-t1x9gknd 11755 14 with with IN cord-010119-t1x9gknd 11755 15 Client Client NNP cord-010119-t1x9gknd 11755 16 sub sub NN cord-010119-t1x9gknd 11755 17 - - NNS cord-010119-t1x9gknd 11755 18 investigators investigator NNS cord-010119-t1x9gknd 11755 19 . . . cord-010119-t1x9gknd 11756 1 Deliverables Deliverables NNP cord-010119-t1x9gknd 11756 2 were be VBD cord-010119-t1x9gknd 11756 3 multiple multiple JJ cord-010119-t1x9gknd 11756 4 including include VBG cord-010119-t1x9gknd 11756 5 Client client NN cord-010119-t1x9gknd 11756 6 requirements requirement NNS cord-010119-t1x9gknd 11756 7 , , , cord-010119-t1x9gknd 11756 8 Vendor vendor NN cord-010119-t1x9gknd 11756 9 responsibilities responsibility NNS cord-010119-t1x9gknd 11756 10 and and CC cord-010119-t1x9gknd 11756 11 Labs Labs NNPS cord-010119-t1x9gknd 11756 12 . . . cord-010119-t1x9gknd 11757 1 Client client NN cord-010119-t1x9gknd 11757 2 onboarding onboarding NN cord-010119-t1x9gknd 11757 3 included include VBD cord-010119-t1x9gknd 11757 4 confidentiality confidentiality NN cord-010119-t1x9gknd 11757 5 agreements agreement NNS cord-010119-t1x9gknd 11757 6 between between IN cord-010119-t1x9gknd 11757 7 Client Client NNP cord-010119-t1x9gknd 11757 8 and and CC cord-010119-t1x9gknd 11757 9 Sponsor Sponsor NNP cord-010119-t1x9gknd 11757 10 . . . cord-010119-t1x9gknd 11758 1 An an DT cord-010119-t1x9gknd 11758 2 immediate immediate JJ cord-010119-t1x9gknd 11758 3 ZKV ZKV NNP cord-010119-t1x9gknd 11758 4 based base VBN cord-010119-t1x9gknd 11758 5 webinar webinar NN cord-010119-t1x9gknd 11758 6 provided provide VBD cord-010119-t1x9gknd 11758 7 materials material NNS cord-010119-t1x9gknd 11758 8 and and CC cord-010119-t1x9gknd 11758 9 understanding understanding NN cord-010119-t1x9gknd 11758 10 of of IN cord-010119-t1x9gknd 11758 11 Sponsor Sponsor NNP cord-010119-t1x9gknd 11758 12 protocol protocol NN cord-010119-t1x9gknd 11758 13 , , , cord-010119-t1x9gknd 11758 14 lab lab NN cord-010119-t1x9gknd 11758 15 test test NN cord-010119-t1x9gknd 11758 16 system system NN cord-010119-t1x9gknd 11758 17 , , , cord-010119-t1x9gknd 11758 18 and and CC cord-010119-t1x9gknd 11758 19 Client client NN cord-010119-t1x9gknd 11758 20 / / SYM cord-010119-t1x9gknd 11758 21 donor donor NN cord-010119-t1x9gknd 11758 22 based base VBN cord-010119-t1x9gknd 11758 23 responsibilities responsibility NNS cord-010119-t1x9gknd 11758 24 . . . cord-010119-t1x9gknd 11759 1 To to TO cord-010119-t1x9gknd 11759 2 facilitate facilitate VB cord-010119-t1x9gknd 11759 3 and and CC cord-010119-t1x9gknd 11759 4 ensure ensure VB cord-010119-t1x9gknd 11759 5 effective effective JJ cord-010119-t1x9gknd 11759 6 communication communication NN cord-010119-t1x9gknd 11759 7 , , , cord-010119-t1x9gknd 11759 8 twice twice JJ cord-010119-t1x9gknd 11759 9 weekly weekly JJ cord-010119-t1x9gknd 11759 10 conference conference NN cord-010119-t1x9gknd 11759 11 calls call NNS cord-010119-t1x9gknd 11759 12 were be VBD cord-010119-t1x9gknd 11759 13 held hold VBN cord-010119-t1x9gknd 11759 14 . . . cord-010119-t1x9gknd 11760 1 Clients client NNS cord-010119-t1x9gknd 11760 2 sent send VBD cord-010119-t1x9gknd 11760 3 questions question NNS cord-010119-t1x9gknd 11760 4 which which WDT cord-010119-t1x9gknd 11760 5 were be VBD cord-010119-t1x9gknd 11760 6 facilitated facilitate VBN cord-010119-t1x9gknd 11760 7 by by IN cord-010119-t1x9gknd 11760 8 Labs Labs NNPS cord-010119-t1x9gknd 11760 9 and and CC cord-010119-t1x9gknd 11760 10 directed direct VBN cord-010119-t1x9gknd 11760 11 to to IN cord-010119-t1x9gknd 11760 12 Sponsor Sponsor NNP cord-010119-t1x9gknd 11760 13 . . . cord-010119-t1x9gknd 11761 1 Specific specific JJ cord-010119-t1x9gknd 11761 2 to to IN cord-010119-t1x9gknd 11761 3 Clients client NNS cord-010119-t1x9gknd 11761 4 were be VBD cord-010119-t1x9gknd 11761 5 IRB IRB NNP cord-010119-t1x9gknd 11761 6 documents document NNS cord-010119-t1x9gknd 11761 7 , , , cord-010119-t1x9gknd 11761 8 IT it PRP cord-010119-t1x9gknd 11761 9 updates update VBZ cord-010119-t1x9gknd 11761 10 / / SYM cord-010119-t1x9gknd 11761 11 validation validation NN cord-010119-t1x9gknd 11761 12 for for IN cord-010119-t1x9gknd 11761 13 ZKV zkv NN cord-010119-t1x9gknd 11761 14 test test NN cord-010119-t1x9gknd 11761 15 ordering ordering NN cord-010119-t1x9gknd 11761 16 and and CC cord-010119-t1x9gknd 11761 17 result result VB cord-010119-t1x9gknd 11761 18 receipt receipt NN cord-010119-t1x9gknd 11761 19 . . . cord-010119-t1x9gknd 11762 1 Labs lab NNS cord-010119-t1x9gknd 11762 2 were be VBD cord-010119-t1x9gknd 11762 3 multifaceted multifacete VBN cord-010119-t1x9gknd 11762 4 : : : cord-010119-t1x9gknd 11762 5 vendor vendor NN cord-010119-t1x9gknd 11762 6 instruments instrument NNS cord-010119-t1x9gknd 11762 7 , , , cord-010119-t1x9gknd 11762 8 assay assay NN cord-010119-t1x9gknd 11762 9 materials material NNS cord-010119-t1x9gknd 11762 10 , , , cord-010119-t1x9gknd 11762 11 package package NN cord-010119-t1x9gknd 11762 12 inserts insert NNS cord-010119-t1x9gknd 11762 13 , , , cord-010119-t1x9gknd 11762 14 staff staff NN cord-010119-t1x9gknd 11762 15 training training NN cord-010119-t1x9gknd 11762 16 . . . cord-010119-t1x9gknd 11763 1 Assessments assessment NNS cord-010119-t1x9gknd 11763 2 included include VBD cord-010119-t1x9gknd 11763 3 : : : cord-010119-t1x9gknd 11763 4 ZKV zkv NN cord-010119-t1x9gknd 11763 5 sample sample NN cord-010119-t1x9gknd 11763 6 volume volume NN cord-010119-t1x9gknd 11763 7 , , , cord-010119-t1x9gknd 11763 8 throughput throughput NN cord-010119-t1x9gknd 11763 9 , , , cord-010119-t1x9gknd 11763 10 instrument instrument NN cord-010119-t1x9gknd 11763 11 capability capability NN cord-010119-t1x9gknd 11763 12 / / SYM cord-010119-t1x9gknd 11763 13 capacity capacity NN cord-010119-t1x9gknd 11763 14 . . . cord-010119-t1x9gknd 11764 1 Work work NN cord-010119-t1x9gknd 11764 2 requirements requirement NNS cord-010119-t1x9gknd 11764 3 included include VBD cord-010119-t1x9gknd 11764 4 Vendor Vendor NNP cord-010119-t1x9gknd 11764 5 installation installation NN cord-010119-t1x9gknd 11764 6 , , , cord-010119-t1x9gknd 11764 7 equipment equipment NN cord-010119-t1x9gknd 11764 8 , , , cord-010119-t1x9gknd 11764 9 assay assay NN cord-010119-t1x9gknd 11764 10 and and CC cord-010119-t1x9gknd 11764 11 reagent reagent NN cord-010119-t1x9gknd 11764 12 qualifications qualification NNS cord-010119-t1x9gknd 11764 13 , , , cord-010119-t1x9gknd 11764 14 staff staff NN cord-010119-t1x9gknd 11764 15 training training NN cord-010119-t1x9gknd 11764 16 , , , cord-010119-t1x9gknd 11764 17 competency competency NN cord-010119-t1x9gknd 11764 18 assessments assessment NNS cord-010119-t1x9gknd 11764 19 , , , cord-010119-t1x9gknd 11764 20 result result NN cord-010119-t1x9gknd 11764 21 reporting report VBG cord-010119-t1x9gknd 11764 22 . . . cord-010119-t1x9gknd 11765 1 All all DT cord-010119-t1x9gknd 11765 2 Clients client NNS cord-010119-t1x9gknd 11765 3 were be VBD cord-010119-t1x9gknd 11765 4 provided provide VBN cord-010119-t1x9gknd 11765 5 with with IN cord-010119-t1x9gknd 11765 6 ZKV zkv NN cord-010119-t1x9gknd 11765 7 testing testing NN cord-010119-t1x9gknd 11765 8 within within IN cord-010119-t1x9gknd 11765 9 required require VBN cord-010119-t1x9gknd 11765 10 timeframes timeframe NNS cord-010119-t1x9gknd 11765 11 . . . cord-010119-t1x9gknd 11766 1 Conclusion conclusion NN cord-010119-t1x9gknd 11766 2 : : : cord-010119-t1x9gknd 11767 1 The the DT cord-010119-t1x9gknd 11767 2 success success NN cord-010119-t1x9gknd 11767 3 in in IN cord-010119-t1x9gknd 11767 4 meeting meet VBG cord-010119-t1x9gknd 11767 5 a a DT cord-010119-t1x9gknd 11767 6 rapid rapid JJ cord-010119-t1x9gknd 11767 7 implementation implementation NN cord-010119-t1x9gknd 11767 8 of of IN cord-010119-t1x9gknd 11767 9 ZKV ZKV NNP cord-010119-t1x9gknd 11767 10 testing testing NN cord-010119-t1x9gknd 11767 11 was be VBD cord-010119-t1x9gknd 11767 12 largely largely RB cord-010119-t1x9gknd 11767 13 due due JJ cord-010119-t1x9gknd 11767 14 to to IN cord-010119-t1x9gknd 11767 15 a a DT cord-010119-t1x9gknd 11767 16 centralized centralized JJ cord-010119-t1x9gknd 11767 17 PMO PMO NNP cord-010119-t1x9gknd 11767 18 system system NN cord-010119-t1x9gknd 11767 19 which which WDT cord-010119-t1x9gknd 11767 20 provided provide VBD cord-010119-t1x9gknd 11767 21 a a DT cord-010119-t1x9gknd 11767 22 controlled control VBN cord-010119-t1x9gknd 11767 23 process process NN cord-010119-t1x9gknd 11767 24 for for IN cord-010119-t1x9gknd 11767 25 Sponsor Sponsor NNP cord-010119-t1x9gknd 11767 26 , , , cord-010119-t1x9gknd 11767 27 Client Client NNP cord-010119-t1x9gknd 11767 28 , , , cord-010119-t1x9gknd 11767 29 Vendor Vendor NNP cord-010119-t1x9gknd 11767 30 and and CC cord-010119-t1x9gknd 11767 31 Labs Labs NNP cord-010119-t1x9gknd 11767 32 . . . cord-010119-t1x9gknd 11768 1 Within within IN cord-010119-t1x9gknd 11768 2 lessons lesson NNS cord-010119-t1x9gknd 11768 3 learned learn VBD cord-010119-t1x9gknd 11768 4 strength strength NN cord-010119-t1x9gknd 11768 5 was be VBD cord-010119-t1x9gknd 11768 6 found find VBN cord-010119-t1x9gknd 11768 7 in in IN cord-010119-t1x9gknd 11768 8 a a DT cord-010119-t1x9gknd 11768 9 multi multi JJ cord-010119-t1x9gknd 11768 10 - - JJ cord-010119-t1x9gknd 11768 11 Client client JJ cord-010119-t1x9gknd 11768 12 onboarding onboarding NN cord-010119-t1x9gknd 11768 13 process process NN cord-010119-t1x9gknd 11768 14 . . . cord-010119-t1x9gknd 11769 1 A a DT cord-010119-t1x9gknd 11769 2 weakness weakness NN cord-010119-t1x9gknd 11769 3 was be VBD cord-010119-t1x9gknd 11769 4 in in IN cord-010119-t1x9gknd 11769 5 understanding understand VBG cord-010119-t1x9gknd 11769 6 instrument instrument NN cord-010119-t1x9gknd 11769 7 test test NN cord-010119-t1x9gknd 11769 8 volume volume NN cord-010119-t1x9gknd 11769 9 capacity capacity NN cord-010119-t1x9gknd 11769 10 throughput throughput NN cord-010119-t1x9gknd 11769 11 which which WDT cord-010119-t1x9gknd 11769 12 was be VBD cord-010119-t1x9gknd 11769 13 exceeded exceed VBN cord-010119-t1x9gknd 11769 14 during during IN cord-010119-t1x9gknd 11769 15 the the DT cord-010119-t1x9gknd 11769 16 4-week 4-week CD cord-010119-t1x9gknd 11769 17 period period NN cord-010119-t1x9gknd 11769 18 but but CC cord-010119-t1x9gknd 11769 19 overcome overcome VBN cord-010119-t1x9gknd 11769 20 during during IN cord-010119-t1x9gknd 11769 21 the the DT cord-010119-t1x9gknd 11769 22 12-week 12-week JJ cord-010119-t1x9gknd 11769 23 cycle cycle NN cord-010119-t1x9gknd 11769 24 . . . cord-010119-t1x9gknd 11770 1 Red Red NNP cord-010119-t1x9gknd 11770 2 Blood blood NN cord-010119-t1x9gknd 11770 3 Cells cell NNS cord-010119-t1x9gknd 11770 4 Baby Baby NNP cord-010119-t1x9gknd 11770 5 Units Units NNPS cord-010119-t1x9gknd 11770 6 Traceability Traceability NNP cord-010119-t1x9gknd 11770 7 and and CC cord-010119-t1x9gknd 11770 8 Discard discard VB cord-010119-t1x9gknd 11770 9 in in IN cord-010119-t1x9gknd 11770 10 Kuwait Kuwait NNP cord-010119-t1x9gknd 11770 11 Central Central NNP cord-010119-t1x9gknd 11770 12 Blood Blood NNP cord-010119-t1x9gknd 11770 13 Bank Bank NNP cord-010119-t1x9gknd 11770 14 and and CC cord-010119-t1x9gknd 11770 15 Five five CD cord-010119-t1x9gknd 11770 16 Hospitals hospital NNS cord-010119-t1x9gknd 11770 17 Marwa Marwa NNP cord-010119-t1x9gknd 11770 18 Moemen Moemen NNP cord-010119-t1x9gknd 11770 19 Al Al NNP cord-010119-t1x9gknd 11770 20 Deeb Deeb NNP cord-010119-t1x9gknd 11771 1 * * NFP cord-010119-t1x9gknd 11771 2 1 1 CD cord-010119-t1x9gknd 11771 3 , , , cord-010119-t1x9gknd 11771 4 Hala Hala NNP cord-010119-t1x9gknd 11771 5 Samuel Samuel NNP cord-010119-t1x9gknd 11771 6 Boules Boules NNP cord-010119-t1x9gknd 11771 7 1 1 CD cord-010119-t1x9gknd 11771 8 , , , cord-010119-t1x9gknd 11771 9 Fatemah Fatemah NNP cord-010119-t1x9gknd 11771 10 Saleh Saleh NNP cord-010119-t1x9gknd 11771 11 Al Al NNP cord-010119-t1x9gknd 11771 12 Matroud Matroud NNP cord-010119-t1x9gknd 11771 13 1 1 CD cord-010119-t1x9gknd 11771 14 , , , cord-010119-t1x9gknd 11771 15 Rabab Rabab NNP cord-010119-t1x9gknd 11771 16 Hussien Hussien NNP cord-010119-t1x9gknd 11771 17 Ali Ali NNP cord-010119-t1x9gknd 11771 18 Dashti Dashti NNP cord-010119-t1x9gknd 11771 19 1 1 CD cord-010119-t1x9gknd 11771 20 , , , cord-010119-t1x9gknd 11771 21 Hanan Hanan NNP cord-010119-t1x9gknd 11771 22 Alawadhi Alawadhi NNP cord-010119-t1x9gknd 11771 23 2 2 CD cord-010119-t1x9gknd 11771 24 and and CC cord-010119-t1x9gknd 11771 25 Reem Reem NNP cord-010119-t1x9gknd 11771 26 Al Al NNP cord-010119-t1x9gknd 11771 27 Radwan Radwan NNP cord-010119-t1x9gknd 11771 28 3 3 CD cord-010119-t1x9gknd 11771 29 . . . cord-010119-t1x9gknd 11772 1 1 1 LS cord-010119-t1x9gknd 11773 1 Kuwait Kuwait NNP cord-010119-t1x9gknd 11773 2 Central Central NNP cord-010119-t1x9gknd 11773 3 Blood Blood NNP cord-010119-t1x9gknd 11773 4 Bank Bank NNP cord-010119-t1x9gknd 11773 5 , , , cord-010119-t1x9gknd 11773 6 2 2 CD cord-010119-t1x9gknd 11773 7 Kuwait Kuwait NNP cord-010119-t1x9gknd 11773 8 central central JJ cord-010119-t1x9gknd 11773 9 blood blood NN cord-010119-t1x9gknd 11773 10 bank bank NN cord-010119-t1x9gknd 11773 11 , , , cord-010119-t1x9gknd 11773 12 3 3 CD cord-010119-t1x9gknd 11773 13 Kuwait Kuwait NNP cord-010119-t1x9gknd 11773 14 central central JJ cord-010119-t1x9gknd 11773 15 Blood Blood NNP cord-010119-t1x9gknd 11773 16 Bank Bank NNP cord-010119-t1x9gknd 11773 17 Background Background NNP cord-010119-t1x9gknd 11773 18 / / SYM cord-010119-t1x9gknd 11773 19 Case Case NNP cord-010119-t1x9gknd 11773 20 Studies Studies NNPS cord-010119-t1x9gknd 11773 21 : : : cord-010119-t1x9gknd 11774 1 Ill ill JJ cord-010119-t1x9gknd 11774 2 children child NNS cord-010119-t1x9gknd 11774 3 are be VBP cord-010119-t1x9gknd 11774 4 more more RBR cord-010119-t1x9gknd 11774 5 likely likely JJ cord-010119-t1x9gknd 11774 6 to to TO cord-010119-t1x9gknd 11774 7 receive receive VB cord-010119-t1x9gknd 11774 8 Red Red NNP cord-010119-t1x9gknd 11774 9 Blood blood NN cord-010119-t1x9gknd 11774 10 Cells cell NNS cord-010119-t1x9gknd 11774 11 ( ( -LRB- cord-010119-t1x9gknd 11774 12 RBCs rbc NNS cord-010119-t1x9gknd 11774 13 ) ) -RRB- cord-010119-t1x9gknd 11774 14 transfusion transfusion NN cord-010119-t1x9gknd 11774 15 than than IN cord-010119-t1x9gknd 11774 16 any any DT cord-010119-t1x9gknd 11774 17 other other JJ cord-010119-t1x9gknd 11774 18 patient patient NN cord-010119-t1x9gknd 11774 19 age age NN cord-010119-t1x9gknd 11774 20 group group NN cord-010119-t1x9gknd 11774 21 . . . cord-010119-t1x9gknd 11775 1 RBCs rbc NNS cord-010119-t1x9gknd 11775 2 are be VBP cord-010119-t1x9gknd 11775 3 the the DT cord-010119-t1x9gknd 11775 4 component component NN cord-010119-t1x9gknd 11775 5 most most RBS cord-010119-t1x9gknd 11775 6 often often RB cord-010119-t1x9gknd 11775 7 transfused transfuse VBN cord-010119-t1x9gknd 11775 8 during during IN cord-010119-t1x9gknd 11775 9 neonatal neonatal JJ cord-010119-t1x9gknd 11775 10 period period NN cord-010119-t1x9gknd 11775 11 . . . cord-010119-t1x9gknd 11776 1 Small small JJ cord-010119-t1x9gknd 11776 2 volume volume NN cord-010119-t1x9gknd 11776 3 aliquots aliquot NNS cord-010119-t1x9gknd 11776 4 are be VBP cord-010119-t1x9gknd 11776 5 used use VBN cord-010119-t1x9gknd 11776 6 to to TO cord-010119-t1x9gknd 11776 7 limit limit VB cord-010119-t1x9gknd 11776 8 donor donor NN cord-010119-t1x9gknd 11776 9 exposure exposure NN cord-010119-t1x9gknd 11776 10 , , , cord-010119-t1x9gknd 11776 11 prevent prevent VB cord-010119-t1x9gknd 11776 12 circulation circulation NN cord-010119-t1x9gknd 11776 13 overload overload NN cord-010119-t1x9gknd 11776 14 and and CC cord-010119-t1x9gknd 11776 15 decrease decrease VB cord-010119-t1x9gknd 11776 16 donor donor NN cord-010119-t1x9gknd 11776 17 related relate VBN cord-010119-t1x9gknd 11776 18 risk risk NN cord-010119-t1x9gknd 11776 19 . . . cord-010119-t1x9gknd 11777 1 Traceability Traceability NNP cord-010119-t1x9gknd 11777 2 is be VBZ cord-010119-t1x9gknd 11777 3 the the DT cord-010119-t1x9gknd 11777 4 ability ability NN cord-010119-t1x9gknd 11777 5 to to TO cord-010119-t1x9gknd 11777 6 trace trace VB cord-010119-t1x9gknd 11777 7 each each DT cord-010119-t1x9gknd 11777 8 individual individual JJ cord-010119-t1x9gknd 11777 9 unit unit NN cord-010119-t1x9gknd 11777 10 from from IN cord-010119-t1x9gknd 11777 11 donor donor NN cord-010119-t1x9gknd 11777 12 to to IN cord-010119-t1x9gknd 11777 13 recipient recipient NN cord-010119-t1x9gknd 11777 14 or or CC cord-010119-t1x9gknd 11777 15 disposal disposal NN cord-010119-t1x9gknd 11777 16 . . . cord-010119-t1x9gknd 11778 1 Blood blood NN cord-010119-t1x9gknd 11778 2 component component NN cord-010119-t1x9gknd 11778 3 should should MD cord-010119-t1x9gknd 11778 4 be be VB cord-010119-t1x9gknd 11778 5 fully fully RB cord-010119-t1x9gknd 11778 6 traceable traceable JJ cord-010119-t1x9gknd 11778 7 from from IN cord-010119-t1x9gknd 11778 8 collection collection NN cord-010119-t1x9gknd 11778 9 to to IN cord-010119-t1x9gknd 11778 10 final final JJ cord-010119-t1x9gknd 11778 11 disposition disposition NN cord-010119-t1x9gknd 11778 12 . . . cord-010119-t1x9gknd 11779 1 The the DT cord-010119-t1x9gknd 11779 2 Kuwait Kuwait NNP cord-010119-t1x9gknd 11779 3 Central Central NNP cord-010119-t1x9gknd 11779 4 Blood Blood NNP cord-010119-t1x9gknd 11779 5 Bank Bank NNP cord-010119-t1x9gknd 11779 6 ( ( -LRB- cord-010119-t1x9gknd 11779 7 KCBB KCBB NNP cord-010119-t1x9gknd 11779 8 ) ) -RRB- cord-010119-t1x9gknd 11779 9 , , , cord-010119-t1x9gknd 11779 10 is be VBZ cord-010119-t1x9gknd 11779 11 preparing prepare VBG cord-010119-t1x9gknd 11779 12 baby baby NN cord-010119-t1x9gknd 11779 13 units unit NNS cord-010119-t1x9gknd 11779 14 and and CC cord-010119-t1x9gknd 11779 15 distributing distribute VBG cord-010119-t1x9gknd 11779 16 it -PRON- PRP cord-010119-t1x9gknd 11779 17 to to IN cord-010119-t1x9gknd 11779 18 all all DT cord-010119-t1x9gknd 11779 19 hospitals hospital NNS cord-010119-t1x9gknd 11779 20 all all RB cord-010119-t1x9gknd 11779 21 over over IN cord-010119-t1x9gknd 11779 22 the the DT cord-010119-t1x9gknd 11779 23 country country NN cord-010119-t1x9gknd 11779 24 . . . cord-010119-t1x9gknd 11780 1 KCBB KCBB NNP cord-010119-t1x9gknd 11780 2 , , , cord-010119-t1x9gknd 11780 3 being be VBG cord-010119-t1x9gknd 11780 4 accredited accredit VBN cord-010119-t1x9gknd 11780 5 by by IN cord-010119-t1x9gknd 11780 6 the the DT cord-010119-t1x9gknd 11780 7 American American NNP cord-010119-t1x9gknd 11780 8 Association Association NNP cord-010119-t1x9gknd 11780 9 of of IN cord-010119-t1x9gknd 11780 10 Blood Blood NNP cord-010119-t1x9gknd 11780 11 Banks Banks NNPS cord-010119-t1x9gknd 11780 12 ( ( -LRB- cord-010119-t1x9gknd 11780 13 AABB AABB NNP cord-010119-t1x9gknd 11780 14 ) ) -RRB- cord-010119-t1x9gknd 11780 15 , , . cord-010119-t1x9gknd 11781 1 is be VBZ cord-010119-t1x9gknd 11781 2 following follow VBG cord-010119-t1x9gknd 11781 3 the the DT cord-010119-t1x9gknd 11781 4 AABB AABB NNP cord-010119-t1x9gknd 11781 5 's 's POS cord-010119-t1x9gknd 11781 6 regulations regulation NNS cord-010119-t1x9gknd 11781 7 in in IN cord-010119-t1x9gknd 11781 8 tracing trace VBG cord-010119-t1x9gknd 11781 9 every every DT cord-010119-t1x9gknd 11781 10 component component NN cord-010119-t1x9gknd 11781 11 . . . cord-010119-t1x9gknd 11782 1 Study Study NNP cord-010119-t1x9gknd 11782 2 Design Design NNP cord-010119-t1x9gknd 11782 3 / / SYM cord-010119-t1x9gknd 11782 4 Method method NN cord-010119-t1x9gknd 11782 5 : : : cord-010119-t1x9gknd 11782 6 This this DT cord-010119-t1x9gknd 11782 7 is be VBZ cord-010119-t1x9gknd 11782 8 a a DT cord-010119-t1x9gknd 11782 9 retrospective retrospective JJ cord-010119-t1x9gknd 11782 10 study study NN cord-010119-t1x9gknd 11782 11 to to TO cord-010119-t1x9gknd 11782 12 assess assess VB cord-010119-t1x9gknd 11782 13 final final JJ cord-010119-t1x9gknd 11782 14 deposition deposition NN cord-010119-t1x9gknd 11782 15 and and CC cord-010119-t1x9gknd 11782 16 the the DT cord-010119-t1x9gknd 11782 17 percentage percentage NN cord-010119-t1x9gknd 11782 18 of of IN cord-010119-t1x9gknd 11782 19 discard discard NN cord-010119-t1x9gknd 11782 20 of of IN cord-010119-t1x9gknd 11782 21 prepared prepared JJ cord-010119-t1x9gknd 11782 22 packed packed JJ cord-010119-t1x9gknd 11782 23 RBCs rbc NNS cord-010119-t1x9gknd 11782 24 baby baby NN cord-010119-t1x9gknd 11782 25 units unit NNS cord-010119-t1x9gknd 11782 26 in in IN cord-010119-t1x9gknd 11782 27 the the DT cord-010119-t1x9gknd 11782 28 KCBB KCBB NNP cord-010119-t1x9gknd 11782 29 and and CC cord-010119-t1x9gknd 11782 30 five five CD cord-010119-t1x9gknd 11782 31 hospital hospital NN cord-010119-t1x9gknd 11782 32 blood blood NN cord-010119-t1x9gknd 11782 33 banks bank NNS cord-010119-t1x9gknd 11782 34 ( ( -LRB- cord-010119-t1x9gknd 11782 35 HBB HBB NNP cord-010119-t1x9gknd 11782 36 ) ) -RRB- cord-010119-t1x9gknd 11782 37 . . . cord-010119-t1x9gknd 11783 1 Also also RB cord-010119-t1x9gknd 11783 2 , , , cord-010119-t1x9gknd 11783 3 to to TO cord-010119-t1x9gknd 11783 4 assess assess VB cord-010119-t1x9gknd 11783 5 the the DT cord-010119-t1x9gknd 11783 6 levels level NNS cord-010119-t1x9gknd 11783 7 of of IN cord-010119-t1x9gknd 11783 8 traceability traceability NN cord-010119-t1x9gknd 11783 9 as as IN cord-010119-t1x9gknd 11783 10 a a DT cord-010119-t1x9gknd 11783 11 reflection reflection NN cord-010119-t1x9gknd 11783 12 of of IN cord-010119-t1x9gknd 11783 13 the the DT cord-010119-t1x9gknd 11783 14 improvement improvement NN cord-010119-t1x9gknd 11783 15 in in IN cord-010119-t1x9gknd 11783 16 the the DT cord-010119-t1x9gknd 11783 17 efficient efficient JJ cord-010119-t1x9gknd 11783 18 use use NN cord-010119-t1x9gknd 11783 19 of of IN cord-010119-t1x9gknd 11783 20 these these DT cord-010119-t1x9gknd 11783 21 blood blood NN cord-010119-t1x9gknd 11783 22 products product NNS cord-010119-t1x9gknd 11783 23 . . . cord-010119-t1x9gknd 11784 1 Methods method NNS cord-010119-t1x9gknd 11784 2 : : : cord-010119-t1x9gknd 11784 3 A a DT cord-010119-t1x9gknd 11784 4 total total NN cord-010119-t1x9gknd 11784 5 of of IN cord-010119-t1x9gknd 11784 6 3000 3000 CD cord-010119-t1x9gknd 11784 7 RBCs rbc NNS cord-010119-t1x9gknd 11784 8 baby baby NN cord-010119-t1x9gknd 11784 9 units unit NNS cord-010119-t1x9gknd 11784 10 were be VBD cord-010119-t1x9gknd 11784 11 randomly randomly RB cord-010119-t1x9gknd 11784 12 chosen choose VBN cord-010119-t1x9gknd 11784 13 to to TO cord-010119-t1x9gknd 11784 14 be be VB cord-010119-t1x9gknd 11784 15 traced trace VBN cord-010119-t1x9gknd 11784 16 to to IN cord-010119-t1x9gknd 11784 17 their -PRON- PRP$ cord-010119-t1x9gknd 11784 18 final final JJ cord-010119-t1x9gknd 11784 19 deposition deposition NN cord-010119-t1x9gknd 11784 20 from from IN cord-010119-t1x9gknd 11784 21 the the DT cord-010119-t1x9gknd 11784 22 year year NN cord-010119-t1x9gknd 11784 23 2012 2012 CD cord-010119-t1x9gknd 11784 24 till till IN cord-010119-t1x9gknd 11784 25 2016 2016 CD cord-010119-t1x9gknd 11784 26 . . . cord-010119-t1x9gknd 11785 1 Half half NN cord-010119-t1x9gknd 11785 2 of of IN cord-010119-t1x9gknd 11785 3 them -PRON- PRP cord-010119-t1x9gknd 11785 4 ( ( -LRB- cord-010119-t1x9gknd 11785 5 1500 1500 CD cord-010119-t1x9gknd 11785 6 units unit NNS cord-010119-t1x9gknd 11785 7 ) ) -RRB- cord-010119-t1x9gknd 11785 8 were be VBD cord-010119-t1x9gknd 11785 9 traced trace VBN cord-010119-t1x9gknd 11785 10 in in IN cord-010119-t1x9gknd 11785 11 KCBB KCBB NNP cord-010119-t1x9gknd 11785 12 . . . cord-010119-t1x9gknd 11786 1 Tables table NNS cord-010119-t1x9gknd 11786 2 showing show VBG cord-010119-t1x9gknd 11786 3 the the DT cord-010119-t1x9gknd 11786 4 numbers number NNS cord-010119-t1x9gknd 11786 5 of of IN cord-010119-t1x9gknd 11786 6 the the DT cord-010119-t1x9gknd 11786 7 chosen choose VBN cord-010119-t1x9gknd 11786 8 units unit NNS cord-010119-t1x9gknd 11786 9 were be VBD cord-010119-t1x9gknd 11786 10 distributed distribute VBN cord-010119-t1x9gknd 11786 11 to to IN cord-010119-t1x9gknd 11786 12 the the DT cord-010119-t1x9gknd 11786 13 five five CD cord-010119-t1x9gknd 11786 14 governmental governmental JJ cord-010119-t1x9gknd 11786 15 HBB HBB NNP cord-010119-t1x9gknd 11786 16 ( ( -LRB- cord-010119-t1x9gknd 11786 17 60 60 CD cord-010119-t1x9gknd 11786 18 units unit NNS cord-010119-t1x9gknd 11786 19 for for IN cord-010119-t1x9gknd 11786 20 each each DT cord-010119-t1x9gknd 11786 21 year year NN cord-010119-t1x9gknd 11786 22 of of IN cord-010119-t1x9gknd 11786 23 the the DT cord-010119-t1x9gknd 11786 24 study study NN cord-010119-t1x9gknd 11786 25 period period NN cord-010119-t1x9gknd 11786 26 ) ) -RRB- cord-010119-t1x9gknd 11786 27 . . . cord-010119-t1x9gknd 11787 1 Results/ Results/ . cord-010119-t1x9gknd 11788 1 Finding finding NN cord-010119-t1x9gknd 11788 2 : : : cord-010119-t1x9gknd 11789 1 Preliminary preliminary JJ cord-010119-t1x9gknd 11789 2 results result NNS cord-010119-t1x9gknd 11789 3 show show VBP cord-010119-t1x9gknd 11789 4 that that IN cord-010119-t1x9gknd 11789 5 the the DT cord-010119-t1x9gknd 11789 6 tracing tracing NN cord-010119-t1x9gknd 11789 7 of of IN cord-010119-t1x9gknd 11789 8 RBCs rbc NNS cord-010119-t1x9gknd 11789 9 baby baby NN cord-010119-t1x9gknd 11789 10 units unit NNS cord-010119-t1x9gknd 11789 11 in in IN cord-010119-t1x9gknd 11789 12 the the DT cord-010119-t1x9gknd 11789 13 KCBB KCBB NNP cord-010119-t1x9gknd 11789 14 is be VBZ cord-010119-t1x9gknd 11789 15 100 100 CD cord-010119-t1x9gknd 11789 16 % % NN cord-010119-t1x9gknd 11789 17 efficient efficient JJ cord-010119-t1x9gknd 11789 18 . . . cord-010119-t1x9gknd 11790 1 Results result NNS cord-010119-t1x9gknd 11790 2 from from IN cord-010119-t1x9gknd 11790 3 other other JJ cord-010119-t1x9gknd 11790 4 hospitals hospital NNS cord-010119-t1x9gknd 11790 5 are be VBP cord-010119-t1x9gknd 11790 6 under under IN cord-010119-t1x9gknd 11790 7 process process NN cord-010119-t1x9gknd 11790 8 . . . cord-010119-t1x9gknd 11791 1 Statistical statistical JJ cord-010119-t1x9gknd 11791 2 analysis analysis NN cord-010119-t1x9gknd 11791 3 of of IN cord-010119-t1x9gknd 11791 4 the the DT cord-010119-t1x9gknd 11791 5 traceability traceability NN cord-010119-t1x9gknd 11791 6 will will MD cord-010119-t1x9gknd 11791 7 be be VB cord-010119-t1x9gknd 11791 8 done do VBN cord-010119-t1x9gknd 11791 9 as as RB cord-010119-t1x9gknd 11791 10 soon soon RB cord-010119-t1x9gknd 11791 11 as as IN cord-010119-t1x9gknd 11791 12 the the DT cord-010119-t1x9gknd 11791 13 data data NN cord-010119-t1x9gknd 11791 14 is be VBZ cord-010119-t1x9gknd 11791 15 collected collect VBN cord-010119-t1x9gknd 11791 16 . . . cord-010119-t1x9gknd 11792 1 The the DT cord-010119-t1x9gknd 11792 2 study study NN cord-010119-t1x9gknd 11792 3 will will MD cord-010119-t1x9gknd 11792 4 analyze analyze VB cord-010119-t1x9gknd 11792 5 the the DT cord-010119-t1x9gknd 11792 6 usage usage NN cord-010119-t1x9gknd 11792 7 of of IN cord-010119-t1x9gknd 11792 8 the the DT cord-010119-t1x9gknd 11792 9 baby baby NN cord-010119-t1x9gknd 11792 10 units unit NNS cord-010119-t1x9gknd 11792 11 in in IN cord-010119-t1x9gknd 11792 12 different different JJ cord-010119-t1x9gknd 11792 13 departments department NNS cord-010119-t1x9gknd 11792 14 and and CC cord-010119-t1x9gknd 11792 15 the the DT cord-010119-t1x9gknd 11792 16 percentage percentage NN cord-010119-t1x9gknd 11792 17 of of IN cord-010119-t1x9gknd 11792 18 discarded discard VBN cord-010119-t1x9gknd 11792 19 units unit NNS cord-010119-t1x9gknd 11792 20 . . . cord-010119-t1x9gknd 11793 1 The the DT cord-010119-t1x9gknd 11793 2 traceability traceability NN cord-010119-t1x9gknd 11793 3 of of IN cord-010119-t1x9gknd 11793 4 RBCs rbc NNS cord-010119-t1x9gknd 11793 5 baby baby NN cord-010119-t1x9gknd 11793 6 units unit NNS cord-010119-t1x9gknd 11793 7 in in IN cord-010119-t1x9gknd 11793 8 the the DT cord-010119-t1x9gknd 11793 9 KCBB KCBB NNP cord-010119-t1x9gknd 11793 10 is be VBZ cord-010119-t1x9gknd 11793 11 excellent excellent JJ cord-010119-t1x9gknd 11793 12 , , , cord-010119-t1x9gknd 11793 13 this this DT cord-010119-t1x9gknd 11793 14 is be VBZ cord-010119-t1x9gknd 11793 15 due due JJ cord-010119-t1x9gknd 11793 16 to to IN cord-010119-t1x9gknd 11793 17 good good JJ cord-010119-t1x9gknd 11793 18 management management NN cord-010119-t1x9gknd 11793 19 and and CC cord-010119-t1x9gknd 11793 20 training training NN cord-010119-t1x9gknd 11793 21 of of IN cord-010119-t1x9gknd 11793 22 the the DT cord-010119-t1x9gknd 11793 23 working work VBG cord-010119-t1x9gknd 11793 24 staff staff NN cord-010119-t1x9gknd 11793 25 and and CC cord-010119-t1x9gknd 11793 26 the the DT cord-010119-t1x9gknd 11793 27 use use NN cord-010119-t1x9gknd 11793 28 of of IN cord-010119-t1x9gknd 11793 29 an an DT cord-010119-t1x9gknd 11793 30 electronic electronic JJ cord-010119-t1x9gknd 11793 31 system system NN cord-010119-t1x9gknd 11793 32 in in IN cord-010119-t1x9gknd 11793 33 registration registration NN cord-010119-t1x9gknd 11793 34 and and CC cord-010119-t1x9gknd 11793 35 issuing issuing NN cord-010119-t1x9gknd 11793 36 . . . cord-010119-t1x9gknd 11794 1 Most Most JJS cord-010119-t1x9gknd 11794 2 of of IN cord-010119-t1x9gknd 11794 3 the the DT cord-010119-t1x9gknd 11794 4 Kuwait Kuwait NNP cord-010119-t1x9gknd 11794 5 governmental governmental JJ cord-010119-t1x9gknd 11794 6 hospitals hospital NNS cord-010119-t1x9gknd 11794 7 are be VBP cord-010119-t1x9gknd 11794 8 using use VBG cord-010119-t1x9gknd 11794 9 electronic electronic JJ cord-010119-t1x9gknd 11794 10 systems system NNS cord-010119-t1x9gknd 11794 11 , , , cord-010119-t1x9gknd 11794 12 so so IN cord-010119-t1x9gknd 11794 13 the the DT cord-010119-t1x9gknd 11794 14 traceability traceability NN cord-010119-t1x9gknd 11794 15 should should MD cord-010119-t1x9gknd 11794 16 be be VB cord-010119-t1x9gknd 11794 17 up up IN cord-010119-t1x9gknd 11794 18 to to IN cord-010119-t1x9gknd 11794 19 the the DT cord-010119-t1x9gknd 11794 20 recommended recommend VBN cord-010119-t1x9gknd 11794 21 levels level NNS cord-010119-t1x9gknd 11794 22 . . . cord-010119-t1x9gknd 11795 1 The the DT cord-010119-t1x9gknd 11795 2 percentage percentage NN cord-010119-t1x9gknd 11795 3 of of IN cord-010119-t1x9gknd 11795 4 discard discard NN cord-010119-t1x9gknd 11795 5 of of IN cord-010119-t1x9gknd 11795 6 the the DT cord-010119-t1x9gknd 11795 7 baby baby NN cord-010119-t1x9gknd 11795 8 units unit NNS cord-010119-t1x9gknd 11795 9 in in IN cord-010119-t1x9gknd 11795 10 the the DT cord-010119-t1x9gknd 11795 11 hospitals hospital NNS cord-010119-t1x9gknd 11795 12 is be VBZ cord-010119-t1x9gknd 11795 13 very very RB cord-010119-t1x9gknd 11795 14 high high JJ cord-010119-t1x9gknd 11795 15 . . . cord-010119-t1x9gknd 11796 1 This this DT cord-010119-t1x9gknd 11796 2 may may MD cord-010119-t1x9gknd 11796 3 be be VB cord-010119-t1x9gknd 11796 4 due due JJ cord-010119-t1x9gknd 11796 5 to to IN cord-010119-t1x9gknd 11796 6 the the DT cord-010119-t1x9gknd 11796 7 practice practice NN cord-010119-t1x9gknd 11796 8 of of IN cord-010119-t1x9gknd 11796 9 using use VBG cord-010119-t1x9gknd 11796 10 fresh fresh JJ cord-010119-t1x9gknd 11796 11 blood blood NN cord-010119-t1x9gknd 11796 12 ( ( -LRB- cord-010119-t1x9gknd 11796 13 < < NNP cord-010119-t1x9gknd 11796 14 5 5 CD cord-010119-t1x9gknd 11796 15 days day NNS cord-010119-t1x9gknd 11796 16 of of IN cord-010119-t1x9gknd 11796 17 donation donation NN cord-010119-t1x9gknd 11796 18 ) ) -RRB- cord-010119-t1x9gknd 11796 19 and and CC cord-010119-t1x9gknd 11796 20 the the DT cord-010119-t1x9gknd 11796 21 reservation reservation NN cord-010119-t1x9gknd 11796 22 of of IN cord-010119-t1x9gknd 11796 23 the the DT cord-010119-t1x9gknd 11796 24 baby baby NN cord-010119-t1x9gknd 11796 25 units unit NNS cord-010119-t1x9gknd 11796 26 of of IN cord-010119-t1x9gknd 11796 27 the the DT cord-010119-t1x9gknd 11796 28 same same JJ cord-010119-t1x9gknd 11796 29 donor donor NN cord-010119-t1x9gknd 11796 30 to to IN cord-010119-t1x9gknd 11796 31 the the DT cord-010119-t1x9gknd 11796 32 same same JJ cord-010119-t1x9gknd 11796 33 baby baby NN cord-010119-t1x9gknd 11796 34 to to TO cord-010119-t1x9gknd 11796 35 reduce reduce VB cord-010119-t1x9gknd 11796 36 the the DT cord-010119-t1x9gknd 11796 37 hazards hazard NNS cord-010119-t1x9gknd 11796 38 of of IN cord-010119-t1x9gknd 11796 39 multiple multiple JJ cord-010119-t1x9gknd 11796 40 donor donor NN cord-010119-t1x9gknd 11796 41 exposure exposure NN cord-010119-t1x9gknd 11796 42 . . . cord-010119-t1x9gknd 11797 1 The the DT cord-010119-t1x9gknd 11797 2 creation creation NN cord-010119-t1x9gknd 11797 3 of of IN cord-010119-t1x9gknd 11797 4 a a DT cord-010119-t1x9gknd 11797 5 national national JJ cord-010119-t1x9gknd 11797 6 policy policy NN cord-010119-t1x9gknd 11797 7 for for IN cord-010119-t1x9gknd 11797 8 using use VBG cord-010119-t1x9gknd 11797 9 RBCs rbc NNS cord-010119-t1x9gknd 11797 10 baby baby NN cord-010119-t1x9gknd 11797 11 units unit NNS cord-010119-t1x9gknd 11797 12 is be VBZ cord-010119-t1x9gknd 11797 13 highly highly RB cord-010119-t1x9gknd 11797 14 recommended recommend VBN cord-010119-t1x9gknd 11797 15 to to TO cord-010119-t1x9gknd 11797 16 reduce reduce VB cord-010119-t1x9gknd 11797 17 the the DT cord-010119-t1x9gknd 11797 18 discard discard NN cord-010119-t1x9gknd 11797 19 of of IN cord-010119-t1x9gknd 11797 20 such such JJ cord-010119-t1x9gknd 11797 21 units unit NNS cord-010119-t1x9gknd 11797 22 . . . cord-010119-t1x9gknd 11798 1 We -PRON- PRP cord-010119-t1x9gknd 11798 2 also also RB cord-010119-t1x9gknd 11798 3 calculated calculate VBD cord-010119-t1x9gknd 11798 4 the the DT cord-010119-t1x9gknd 11798 5 number number NN cord-010119-t1x9gknd 11798 6 of of IN cord-010119-t1x9gknd 11798 7 false false JJ cord-010119-t1x9gknd 11798 8 positive positive JJ cord-010119-t1x9gknd 11798 9 results result NNS cord-010119-t1x9gknd 11798 10 . . . cord-010119-t1x9gknd 11799 1 The the DT cord-010119-t1x9gknd 11799 2 study study NN cord-010119-t1x9gknd 11799 3 traced trace VBD cord-010119-t1x9gknd 11799 4 all all DT cord-010119-t1x9gknd 11799 5 products product NNS cord-010119-t1x9gknd 11799 6 through through IN cord-010119-t1x9gknd 11799 7 mid mid NNP cord-010119-t1x9gknd 11799 8 - - NNP cord-010119-t1x9gknd 11799 9 March March NNP cord-010119-t1x9gknd 11799 10 2017 2017 CD cord-010119-t1x9gknd 11799 11 . . . cord-010119-t1x9gknd 11800 1 Results result NNS cord-010119-t1x9gknd 11800 2 / / SYM cord-010119-t1x9gknd 11800 3 Findings finding NNS cord-010119-t1x9gknd 11800 4 : : : cord-010119-t1x9gknd 11801 1 A a DT cord-010119-t1x9gknd 11801 2 total total NN cord-010119-t1x9gknd 11801 3 of of IN cord-010119-t1x9gknd 11801 4 339 339 CD cord-010119-t1x9gknd 11801 5 products product NNS cord-010119-t1x9gknd 11801 6 were be VBD cord-010119-t1x9gknd 11801 7 tested test VBN cord-010119-t1x9gknd 11801 8 . . . cord-010119-t1x9gknd 11802 1 Fifteen fifteen CD cord-010119-t1x9gknd 11802 2 units unit NNS cord-010119-t1x9gknd 11802 3 ( ( -LRB- cord-010119-t1x9gknd 11802 4 4 4 CD cord-010119-t1x9gknd 11802 5 % % NN cord-010119-t1x9gknd 11802 6 ) ) -RRB- cord-010119-t1x9gknd 11802 7 had have VBD cord-010119-t1x9gknd 11802 8 a a DT cord-010119-t1x9gknd 11802 9 false false JJ cord-010119-t1x9gknd 11802 10 positive positive JJ cord-010119-t1x9gknd 11802 11 result result NN cord-010119-t1x9gknd 11802 12 and and CC cord-010119-t1x9gknd 11802 13 could could MD cord-010119-t1x9gknd 11802 14 not not RB cord-010119-t1x9gknd 11802 15 have have VB cord-010119-t1x9gknd 11802 16 their -PRON- PRP$ cord-010119-t1x9gknd 11802 17 life life NN cord-010119-t1x9gknd 11802 18 span span NN cord-010119-t1x9gknd 11802 19 extended extend VBN cord-010119-t1x9gknd 11802 20 . . . cord-010119-t1x9gknd 11803 1 Of of IN cord-010119-t1x9gknd 11803 2 the the DT cord-010119-t1x9gknd 11803 3 fifteen fifteen CD cord-010119-t1x9gknd 11803 4 reactive reactive JJ cord-010119-t1x9gknd 11803 5 units unit NNS cord-010119-t1x9gknd 11803 6 , , , cord-010119-t1x9gknd 11803 7 two two CD cord-010119-t1x9gknd 11803 8 repeat repeat NN cord-010119-t1x9gknd 11803 9 donors donor NNS cord-010119-t1x9gknd 11803 10 were be VBD cord-010119-t1x9gknd 11803 11 identified identify VBN cord-010119-t1x9gknd 11803 12 and and CC cord-010119-t1x9gknd 11803 13 their -PRON- PRP$ cord-010119-t1x9gknd 11803 14 charts chart NNS cord-010119-t1x9gknd 11803 15 were be VBD cord-010119-t1x9gknd 11803 16 marked mark VBN cord-010119-t1x9gknd 11803 17 to to TO cord-010119-t1x9gknd 11803 18 not not RB cord-010119-t1x9gknd 11803 19 test test VB cord-010119-t1x9gknd 11803 20 subsequent subsequent JJ cord-010119-t1x9gknd 11803 21 donations donation NNS cord-010119-t1x9gknd 11803 22 . . . cord-010119-t1x9gknd 11804 1 Cross cross JJ cord-010119-t1x9gknd 11804 2 - - JJ cord-010119-t1x9gknd 11804 3 reactive reactive JJ cord-010119-t1x9gknd 11804 4 antibodies antibody NNS cord-010119-t1x9gknd 11804 5 were be VBD cord-010119-t1x9gknd 11804 6 identified identify VBN cord-010119-t1x9gknd 11804 7 in in IN cord-010119-t1x9gknd 11804 8 all all DT cord-010119-t1x9gknd 11804 9 15 15 CD cord-010119-t1x9gknd 11804 10 by by IN cord-010119-t1x9gknd 11804 11 the the DT cord-010119-t1x9gknd 11804 12 vendor vendor NN cord-010119-t1x9gknd 11804 13 and and CC cord-010119-t1x9gknd 11804 14 none none NN cord-010119-t1x9gknd 11804 15 were be VBD cord-010119-t1x9gknd 11804 16 true true JJ cord-010119-t1x9gknd 11804 17 positives positive NNS cord-010119-t1x9gknd 11804 18 by by IN cord-010119-t1x9gknd 11804 19 re re NN cord-010119-t1x9gknd 11804 20 - - NN cord-010119-t1x9gknd 11804 21 culture culture NN cord-010119-t1x9gknd 11804 22 . . . cord-010119-t1x9gknd 11805 1 Of of IN cord-010119-t1x9gknd 11805 2 the the DT cord-010119-t1x9gknd 11805 3 324 324 CD cord-010119-t1x9gknd 11805 4 units unit NNS cord-010119-t1x9gknd 11805 5 that that WDT cord-010119-t1x9gknd 11805 6 were be VBD cord-010119-t1x9gknd 11805 7 successfully successfully RB cord-010119-t1x9gknd 11805 8 tested test VBN cord-010119-t1x9gknd 11805 9 , , , cord-010119-t1x9gknd 11805 10 200 200 CD cord-010119-t1x9gknd 11805 11 were be VBD cord-010119-t1x9gknd 11805 12 tested test VBN cord-010119-t1x9gknd 11805 13 again again RB cord-010119-t1x9gknd 11805 14 on on IN cord-010119-t1x9gknd 11805 15 day day NN cord-010119-t1x9gknd 11805 16 6 6 CD cord-010119-t1x9gknd 11805 17 for for IN cord-010119-t1x9gknd 11805 18 use use NN cord-010119-t1x9gknd 11805 19 on on IN cord-010119-t1x9gknd 11805 20 day day NN cord-010119-t1x9gknd 11805 21 7(62 7(62 CD cord-010119-t1x9gknd 11805 22 % % NN cord-010119-t1x9gknd 11805 23 ) ) -RRB- cord-010119-t1x9gknd 11805 24 . . . cord-010119-t1x9gknd 11806 1 There there EX cord-010119-t1x9gknd 11806 2 were be VBD cord-010119-t1x9gknd 11806 3 166 166 CD cord-010119-t1x9gknd 11806 4 platelets platelet NNS cord-010119-t1x9gknd 11806 5 transfused transfuse VBN cord-010119-t1x9gknd 11806 6 ( ( -LRB- cord-010119-t1x9gknd 11806 7 51 51 CD cord-010119-t1x9gknd 11806 8 % % NN cord-010119-t1x9gknd 11806 9 ) ) -RRB- cord-010119-t1x9gknd 11806 10 and and CC cord-010119-t1x9gknd 11806 11 158 158 CD cord-010119-t1x9gknd 11806 12 expired expire VBD cord-010119-t1x9gknd 11806 13 after after IN cord-010119-t1x9gknd 11806 14 day day NN cord-010119-t1x9gknd 11806 15 7 7 CD cord-010119-t1x9gknd 11806 16 ( ( -LRB- cord-010119-t1x9gknd 11806 17 49 49 CD cord-010119-t1x9gknd 11806 18 % % NN cord-010119-t1x9gknd 11806 19 ) ) -RRB- cord-010119-t1x9gknd 11806 20 . . . cord-010119-t1x9gknd 11807 1 The the DT cord-010119-t1x9gknd 11807 2 cost cost NN cord-010119-t1x9gknd 11807 3 to to TO cord-010119-t1x9gknd 11807 4 test test VB cord-010119-t1x9gknd 11807 5 the the DT cord-010119-t1x9gknd 11807 6 products product NNS cord-010119-t1x9gknd 11807 7 including include VBG cord-010119-t1x9gknd 11807 8 controls control NNS cord-010119-t1x9gknd 11807 9 was be VBD cord-010119-t1x9gknd 11807 10 $ $ $ cord-010119-t1x9gknd 11807 11 12,970 12,970 CD cord-010119-t1x9gknd 11807 12 and and CC cord-010119-t1x9gknd 11807 13 our -PRON- PRP$ cord-010119-t1x9gknd 11807 14 calculated calculate VBN cord-010119-t1x9gknd 11807 15 cost cost NN cord-010119-t1x9gknd 11807 16 to to TO cord-010119-t1x9gknd 11807 17 produce produce VB cord-010119-t1x9gknd 11807 18 324 324 CD cord-010119-t1x9gknd 11807 19 products product NNS cord-010119-t1x9gknd 11807 20 would would MD cord-010119-t1x9gknd 11807 21 be be VB cord-010119-t1x9gknd 11807 22 $ $ $ cord-010119-t1x9gknd 11807 23 77,436 77,436 CD cord-010119-t1x9gknd 11807 24 . . . cord-010119-t1x9gknd 11808 1 If if IN cord-010119-t1x9gknd 11808 2 we -PRON- PRP cord-010119-t1x9gknd 11808 3 had have VBD cord-010119-t1x9gknd 11808 4 needed need VBN cord-010119-t1x9gknd 11808 5 to to TO cord-010119-t1x9gknd 11808 6 import import VB cord-010119-t1x9gknd 11808 7 products product NNS cord-010119-t1x9gknd 11808 8 to to TO cord-010119-t1x9gknd 11808 9 meet meet VB cord-010119-t1x9gknd 11808 10 needs need NNS cord-010119-t1x9gknd 11808 11 , , , cord-010119-t1x9gknd 11808 12 the the DT cord-010119-t1x9gknd 11808 13 cost cost NN cord-010119-t1x9gknd 11808 14 would would MD cord-010119-t1x9gknd 11808 15 be be VB cord-010119-t1x9gknd 11808 16 roughly roughly RB cord-010119-t1x9gknd 11808 17 $ $ $ cord-010119-t1x9gknd 11808 18 91,300 91,300 CD cord-010119-t1x9gknd 11808 19 without without IN cord-010119-t1x9gknd 11808 20 shipping shipping NN cord-010119-t1x9gknd 11808 21 costs cost NNS cord-010119-t1x9gknd 11808 22 which which WDT cord-010119-t1x9gknd 11808 23 are be VBP cord-010119-t1x9gknd 11808 24 estimated estimate VBN cord-010119-t1x9gknd 11808 25 at at IN cord-010119-t1x9gknd 11808 26 $ $ $ cord-010119-t1x9gknd 11808 27 14,815.50 14,815.50 CD cord-010119-t1x9gknd 11808 28 . . . cord-010119-t1x9gknd 11809 1 We -PRON- PRP cord-010119-t1x9gknd 11809 2 averaged average VBD cord-010119-t1x9gknd 11809 3 40 40 CD cord-010119-t1x9gknd 11809 4 expired expired JJ cord-010119-t1x9gknd 11809 5 platelet platelet NN cord-010119-t1x9gknd 11809 6 products product NNS cord-010119-t1x9gknd 11809 7 per per IN cord-010119-t1x9gknd 11809 8 month month NN cord-010119-t1x9gknd 11809 9 ( ( -LRB- cord-010119-t1x9gknd 11809 10 range range NNP cord-010119-t1x9gknd 11809 11 6 6 CD cord-010119-t1x9gknd 11809 12 - - SYM cord-010119-t1x9gknd 11809 13 67 67 CD cord-010119-t1x9gknd 11809 14 ) ) -RRB- cord-010119-t1x9gknd 11809 15 before before IN cord-010119-t1x9gknd 11809 16 Verax Verax NNP cord-010119-t1x9gknd 11809 17 testing testing NN cord-010119-t1x9gknd 11809 18 and and CC cord-010119-t1x9gknd 11809 19 26 26 CD cord-010119-t1x9gknd 11810 1 ( ( -LRB- cord-010119-t1x9gknd 11810 2 range range NNP cord-010119-t1x9gknd 11810 3 9 9 CD cord-010119-t1x9gknd 11810 4 - - SYM cord-010119-t1x9gknd 11810 5 40 40 CD cord-010119-t1x9gknd 11810 6 ) ) -RRB- cord-010119-t1x9gknd 11810 7 after after IN cord-010119-t1x9gknd 11810 8 implementation implementation NN cord-010119-t1x9gknd 11810 9 . . . cord-010119-t1x9gknd 11811 1 Conclusion conclusion NN cord-010119-t1x9gknd 11811 2 : : : cord-010119-t1x9gknd 11812 1 Using use VBG cord-010119-t1x9gknd 11812 2 Verax Verax NNP cord-010119-t1x9gknd 11812 3 point point NN cord-010119-t1x9gknd 11812 4 - - HYPH cord-010119-t1x9gknd 11812 5 of of IN cord-010119-t1x9gknd 11812 6 - - HYPH cord-010119-t1x9gknd 11812 7 care care NN cord-010119-t1x9gknd 11812 8 testing testing NN cord-010119-t1x9gknd 11812 9 saved save VBD cord-010119-t1x9gknd 11812 10 166 166 CD cord-010119-t1x9gknd 11812 11 platelet platelet NN cord-010119-t1x9gknd 11812 12 products product NNS cord-010119-t1x9gknd 11812 13 from from IN cord-010119-t1x9gknd 11812 14 discard discard NN cord-010119-t1x9gknd 11812 15 . . . cord-010119-t1x9gknd 11813 1 The the DT cord-010119-t1x9gknd 11813 2 cost cost NN cord-010119-t1x9gknd 11813 3 savings saving NNS cord-010119-t1x9gknd 11813 4 were be VBD cord-010119-t1x9gknd 11813 5 $ $ $ cord-010119-t1x9gknd 11813 6 93,145.50 93,145.50 CD cord-010119-t1x9gknd 11813 7 from from IN cord-010119-t1x9gknd 11813 8 importing import VBG cord-010119-t1x9gknd 11813 9 and and CC cord-010119-t1x9gknd 11813 10 $ $ $ cord-010119-t1x9gknd 11813 11 64,466 64,466 CD cord-010119-t1x9gknd 11813 12 from from IN cord-010119-t1x9gknd 11813 13 producing produce VBG cord-010119-t1x9gknd 11813 14 a a DT cord-010119-t1x9gknd 11813 15 replacement replacement NN cord-010119-t1x9gknd 11813 16 for for IN cord-010119-t1x9gknd 11813 17 those those DT cord-010119-t1x9gknd 11813 18 324 324 CD cord-010119-t1x9gknd 11813 19 products product NNS cord-010119-t1x9gknd 11813 20 . . . cord-010119-t1x9gknd 11814 1 The the DT cord-010119-t1x9gknd 11814 2 average average JJ cord-010119-t1x9gknd 11814 3 discard discard VB cord-010119-t1x9gknd 11814 4 rate rate NN cord-010119-t1x9gknd 11814 5 per per IN cord-010119-t1x9gknd 11814 6 month month NN cord-010119-t1x9gknd 11814 7 went go VBD cord-010119-t1x9gknd 11814 8 from from IN cord-010119-t1x9gknd 11814 9 40 40 CD cord-010119-t1x9gknd 11814 10 to to TO cord-010119-t1x9gknd 11814 11 26 26 CD cord-010119-t1x9gknd 11814 12 after after IN cord-010119-t1x9gknd 11814 13 Verax Verax NNP cord-010119-t1x9gknd 11814 14 implementation implementation NN cord-010119-t1x9gknd 11814 15 . . . cord-010119-t1x9gknd 11815 1 Extending extend VBG cord-010119-t1x9gknd 11815 2 platelet platelet NN cord-010119-t1x9gknd 11815 3 shelf shelf NN cord-010119-t1x9gknd 11815 4 life life NN cord-010119-t1x9gknd 11815 5 to to IN cord-010119-t1x9gknd 11815 6 7 7 CD cord-010119-t1x9gknd 11815 7 days day NNS cord-010119-t1x9gknd 11815 8 more more JJR cord-010119-t1x9gknd 11815 9 than than IN cord-010119-t1x9gknd 11815 10 paid pay VBN cord-010119-t1x9gknd 11815 11 for for IN cord-010119-t1x9gknd 11815 12 the the DT cord-010119-t1x9gknd 11815 13 cost cost NN cord-010119-t1x9gknd 11815 14 of of IN cord-010119-t1x9gknd 11815 15 testing testing NN cord-010119-t1x9gknd 11815 16 and and CC cord-010119-t1x9gknd 11815 17 ensured ensure VBN cord-010119-t1x9gknd 11815 18 products product NNS cord-010119-t1x9gknd 11815 19 were be VBD cord-010119-t1x9gknd 11815 20 available available JJ cord-010119-t1x9gknd 11815 21 for for IN cord-010119-t1x9gknd 11815 22 patients patient NNS cord-010119-t1x9gknd 11815 23 who who WP cord-010119-t1x9gknd 11815 24 needed need VBD cord-010119-t1x9gknd 11815 25 them -PRON- PRP cord-010119-t1x9gknd 11815 26 . . . cord-010119-t1x9gknd 11816 1 Secure Secure NNP cord-010119-t1x9gknd 11816 2 Text Text NNP cord-010119-t1x9gknd 11816 3 Messaging Messaging NNP cord-010119-t1x9gknd 11816 4 in in IN cord-010119-t1x9gknd 11816 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 11816 6 Medicine Medicine NNP cord-010119-t1x9gknd 11816 7 : : : cord-010119-t1x9gknd 11817 1 Can Can MD cord-010119-t1x9gknd 11817 2 Texting texte VBG cord-010119-t1x9gknd 11817 3 Decrease decrease VB cord-010119-t1x9gknd 11817 4 Wastage wastage NN cord-010119-t1x9gknd 11817 5 ? ? . cord-010119-t1x9gknd 11818 1 Melanie Melanie NNP cord-010119-t1x9gknd 11818 2 Estrella Estrella NNP cord-010119-t1x9gknd 11818 3 * * NFP cord-010119-t1x9gknd 11818 4 and and CC cord-010119-t1x9gknd 11818 5 Elsie Elsie NNP cord-010119-t1x9gknd 11818 6 Lee Lee NNP cord-010119-t1x9gknd 11818 7 . . . cord-010119-t1x9gknd 11819 1 George George NNP cord-010119-t1x9gknd 11819 2 Washington Washington NNP cord-010119-t1x9gknd 11819 3 University University NNP cord-010119-t1x9gknd 11819 4 Hospital Hospital NNP cord-010119-t1x9gknd 11819 5 Background Background NNP cord-010119-t1x9gknd 11819 6 / / SYM cord-010119-t1x9gknd 11819 7 Case Case NNP cord-010119-t1x9gknd 11819 8 Studies Studies NNPS cord-010119-t1x9gknd 11819 9 : : : cord-010119-t1x9gknd 11820 1 Secure secure JJ cord-010119-t1x9gknd 11820 2 text text NN cord-010119-t1x9gknd 11820 3 messaging messaging NN cord-010119-t1x9gknd 11820 4 in in IN cord-010119-t1x9gknd 11820 5 hospital hospital NN cord-010119-t1x9gknd 11820 6 settings setting NNS cord-010119-t1x9gknd 11820 7 allows allow VBZ cord-010119-t1x9gknd 11820 8 for for IN cord-010119-t1x9gknd 11820 9 quick quick JJ cord-010119-t1x9gknd 11820 10 , , , cord-010119-t1x9gknd 11820 11 easy easy JJ cord-010119-t1x9gknd 11820 12 , , , cord-010119-t1x9gknd 11820 13 and and CC cord-010119-t1x9gknd 11820 14 HIPAA HIPAA NNP cord-010119-t1x9gknd 11820 15 compliant compliant JJ cord-010119-t1x9gknd 11820 16 communication communication NN cord-010119-t1x9gknd 11820 17 between between IN cord-010119-t1x9gknd 11820 18 members member NNS cord-010119-t1x9gknd 11820 19 of of IN cord-010119-t1x9gknd 11820 20 patient patient JJ cord-010119-t1x9gknd 11820 21 care care NN cord-010119-t1x9gknd 11820 22 teams team NNS cord-010119-t1x9gknd 11820 23 . . . cord-010119-t1x9gknd 11821 1 It -PRON- PRP cord-010119-t1x9gknd 11821 2 works work VBZ cord-010119-t1x9gknd 11821 3 on on IN cord-010119-t1x9gknd 11821 4 a a DT cord-010119-t1x9gknd 11821 5 mobile mobile JJ cord-010119-t1x9gknd 11821 6 phone phone NN cord-010119-t1x9gknd 11821 7 or or CC cord-010119-t1x9gknd 11821 8 computer computer NN cord-010119-t1x9gknd 11821 9 , , , cord-010119-t1x9gknd 11821 10 and and CC cord-010119-t1x9gknd 11821 11 provides provide VBZ cord-010119-t1x9gknd 11821 12 read read VBN cord-010119-t1x9gknd 11821 13 - - HYPH cord-010119-t1x9gknd 11821 14 receipt receipt NN cord-010119-t1x9gknd 11821 15 confirmation confirmation NN cord-010119-t1x9gknd 11821 16 and and CC cord-010119-t1x9gknd 11821 17 a a DT cord-010119-t1x9gknd 11821 18 temporary temporary JJ cord-010119-t1x9gknd 11821 19 record record NN cord-010119-t1x9gknd 11821 20 of of IN cord-010119-t1x9gknd 11821 21 team team NN cord-010119-t1x9gknd 11821 22 communications communication NNS cord-010119-t1x9gknd 11821 23 . . . cord-010119-t1x9gknd 11822 1 Secure secure JJ cord-010119-t1x9gknd 11822 2 texting texting NN cord-010119-t1x9gknd 11822 3 has have VBZ cord-010119-t1x9gknd 11822 4 potential potential NN cord-010119-t1x9gknd 11822 5 to to TO cord-010119-t1x9gknd 11822 6 be be VB cord-010119-t1x9gknd 11822 7 a a DT cord-010119-t1x9gknd 11822 8 useful useful JJ cord-010119-t1x9gknd 11822 9 management management NN cord-010119-t1x9gknd 11822 10 tool tool NN cord-010119-t1x9gknd 11822 11 in in IN cord-010119-t1x9gknd 11822 12 Transfusion Transfusion NNP cord-010119-t1x9gknd 11822 13 Medicine Medicine NNP cord-010119-t1x9gknd 11822 14 in in IN cord-010119-t1x9gknd 11822 15 reducing reduce VBG cord-010119-t1x9gknd 11822 16 blood blood NN cord-010119-t1x9gknd 11822 17 product product NN cord-010119-t1x9gknd 11822 18 wastage wastage NN cord-010119-t1x9gknd 11822 19 . . . cord-010119-t1x9gknd 11823 1 For for IN cord-010119-t1x9gknd 11823 2 example example NN cord-010119-t1x9gknd 11823 3 , , , cord-010119-t1x9gknd 11823 4 it -PRON- PRP cord-010119-t1x9gknd 11823 5 provides provide VBZ cord-010119-t1x9gknd 11823 6 a a DT cord-010119-t1x9gknd 11823 7 relatively relatively RB cord-010119-t1x9gknd 11823 8 low low JJ cord-010119-t1x9gknd 11823 9 - - HYPH cord-010119-t1x9gknd 11823 10 burden burden NN cord-010119-t1x9gknd 11823 11 means mean NNS cord-010119-t1x9gknd 11823 12 for for IN cord-010119-t1x9gknd 11823 13 busy busy JJ cord-010119-t1x9gknd 11823 14 clinicians clinician NNS cord-010119-t1x9gknd 11823 15 to to TO cord-010119-t1x9gknd 11823 16 provide provide VB cord-010119-t1x9gknd 11823 17 feedback feedback NN cord-010119-t1x9gknd 11823 18 to to IN cord-010119-t1x9gknd 11823 19 the the DT cord-010119-t1x9gknd 11823 20 Transfusion Transfusion NNP cord-010119-t1x9gknd 11823 21 Service Service NNP cord-010119-t1x9gknd 11823 22 about about IN cord-010119-t1x9gknd 11823 23 scenarios scenario NNS cord-010119-t1x9gknd 11823 24 of of IN cord-010119-t1x9gknd 11823 25 potential potential JJ cord-010119-t1x9gknd 11823 26 wastage wastage NN cord-010119-t1x9gknd 11823 27 . . . cord-010119-t1x9gknd 11824 1 This this DT cord-010119-t1x9gknd 11824 2 information information NN cord-010119-t1x9gknd 11824 3 can can MD cord-010119-t1x9gknd 11824 4 be be VB cord-010119-t1x9gknd 11824 5 used use VBN cord-010119-t1x9gknd 11824 6 to to TO cord-010119-t1x9gknd 11824 7 identify identify VB cord-010119-t1x9gknd 11824 8 areas area NNS cord-010119-t1x9gknd 11824 9 in in IN cord-010119-t1x9gknd 11824 10 which which WDT cord-010119-t1x9gknd 11824 11 management management NN cord-010119-t1x9gknd 11824 12 strategies strategy NNS cord-010119-t1x9gknd 11824 13 could could MD cord-010119-t1x9gknd 11824 14 be be VB cord-010119-t1x9gknd 11824 15 developed develop VBN cord-010119-t1x9gknd 11824 16 . . . cord-010119-t1x9gknd 11825 1 It -PRON- PRP cord-010119-t1x9gknd 11825 2 also also RB cord-010119-t1x9gknd 11825 3 allows allow VBZ cord-010119-t1x9gknd 11825 4 for for IN cord-010119-t1x9gknd 11825 5 personalized personalized JJ cord-010119-t1x9gknd 11825 6 educational educational JJ cord-010119-t1x9gknd 11825 7 opportunities opportunity NNS cord-010119-t1x9gknd 11825 8 between between IN cord-010119-t1x9gknd 11825 9 clinicians clinician NNS cord-010119-t1x9gknd 11825 10 and and CC cord-010119-t1x9gknd 11825 11 the the DT cord-010119-t1x9gknd 11825 12 blood blood NN cord-010119-t1x9gknd 11825 13 bank bank NN cord-010119-t1x9gknd 11825 14 about about IN cord-010119-t1x9gknd 11825 15 usage usage NN cord-010119-t1x9gknd 11825 16 guidelines guideline NNS cord-010119-t1x9gknd 11825 17 and and CC cord-010119-t1x9gknd 11825 18 how how WRB cord-010119-t1x9gknd 11825 19 to to TO cord-010119-t1x9gknd 11825 20 reduce reduce VB cord-010119-t1x9gknd 11825 21 future future JJ cord-010119-t1x9gknd 11825 22 wastage wastage NN cord-010119-t1x9gknd 11825 23 . . . cord-010119-t1x9gknd 11826 1 The the DT cord-010119-t1x9gknd 11826 2 goal goal NN cord-010119-t1x9gknd 11826 3 of of IN cord-010119-t1x9gknd 11826 4 this this DT cord-010119-t1x9gknd 11826 5 study study NN cord-010119-t1x9gknd 11826 6 is be VBZ cord-010119-t1x9gknd 11826 7 to to TO cord-010119-t1x9gknd 11826 8 use use VB cord-010119-t1x9gknd 11826 9 secure secure JJ cord-010119-t1x9gknd 11826 10 texting texting NN cord-010119-t1x9gknd 11826 11 to to TO cord-010119-t1x9gknd 11826 12 investigate investigate VB cord-010119-t1x9gknd 11826 13 wastage wastage NN cord-010119-t1x9gknd 11826 14 , , , cord-010119-t1x9gknd 11826 15 evaluate evaluate VB cord-010119-t1x9gknd 11826 16 the the DT cord-010119-t1x9gknd 11826 17 responses response NNS cord-010119-t1x9gknd 11826 18 from from IN cord-010119-t1x9gknd 11826 19 clinicians clinician NNS cord-010119-t1x9gknd 11826 20 , , , cord-010119-t1x9gknd 11826 21 and and CC cord-010119-t1x9gknd 11826 22 evaluate evaluate VB cord-010119-t1x9gknd 11826 23 the the DT cord-010119-t1x9gknd 11826 24 potential potential JJ cord-010119-t1x9gknd 11826 25 effects effect NNS cord-010119-t1x9gknd 11826 26 on on IN cord-010119-t1x9gknd 11826 27 reducing reduce VBG cord-010119-t1x9gknd 11826 28 wastage wastage NN cord-010119-t1x9gknd 11826 29 . . . cord-010119-t1x9gknd 11827 1 It -PRON- PRP cord-010119-t1x9gknd 11827 2 is be VBZ cord-010119-t1x9gknd 11827 3 hoped hope VBN cord-010119-t1x9gknd 11827 4 that that IN cord-010119-t1x9gknd 11827 5 the the DT cord-010119-t1x9gknd 11827 6 results result NNS cord-010119-t1x9gknd 11827 7 will will MD cord-010119-t1x9gknd 11827 8 identify identify VB cord-010119-t1x9gknd 11827 9 secure secure JJ cord-010119-t1x9gknd 11827 10 texting texting NN cord-010119-t1x9gknd 11827 11 as as IN cord-010119-t1x9gknd 11827 12 a a DT cord-010119-t1x9gknd 11827 13 useful useful JJ cord-010119-t1x9gknd 11827 14 management management NN cord-010119-t1x9gknd 11827 15 tool tool NN cord-010119-t1x9gknd 11827 16 in in IN cord-010119-t1x9gknd 11827 17 Transfusion Transfusion NNP cord-010119-t1x9gknd 11827 18 Medicine Medicine NNP cord-010119-t1x9gknd 11827 19 . . . cord-010119-t1x9gknd 11828 1 Study Study NNP cord-010119-t1x9gknd 11828 2 Design Design NNP cord-010119-t1x9gknd 11828 3 / / SYM cord-010119-t1x9gknd 11828 4 Method method NN cord-010119-t1x9gknd 11828 5 : : : cord-010119-t1x9gknd 11829 1 Wastage wastage NN cord-010119-t1x9gknd 11829 2 records record NNS cord-010119-t1x9gknd 11829 3 that that WDT cord-010119-t1x9gknd 11829 4 were be VBD cord-010119-t1x9gknd 11829 5 investigated investigate VBN cord-010119-t1x9gknd 11829 6 without without IN cord-010119-t1x9gknd 11829 7 the the DT cord-010119-t1x9gknd 11829 8 assistance assistance NN cord-010119-t1x9gknd 11829 9 of of IN cord-010119-t1x9gknd 11829 10 secure secure JJ cord-010119-t1x9gknd 11829 11 texting texting NN cord-010119-t1x9gknd 11829 12 from from IN cord-010119-t1x9gknd 11829 13 July July NNP cord-010119-t1x9gknd 11829 14 to to IN cord-010119-t1x9gknd 11829 15 December December NNP cord-010119-t1x9gknd 11829 16 2016 2016 CD cord-010119-t1x9gknd 11829 17 were be VBD cord-010119-t1x9gknd 11829 18 reviewed review VBN cord-010119-t1x9gknd 11829 19 to to TO cord-010119-t1x9gknd 11829 20 identify identify VB cord-010119-t1x9gknd 11829 21 the the DT cord-010119-t1x9gknd 11829 22 most most RBS cord-010119-t1x9gknd 11829 23 common common JJ cord-010119-t1x9gknd 11829 24 scenarios scenario NNS cord-010119-t1x9gknd 11829 25 of of IN cord-010119-t1x9gknd 11829 26 preventable preventable JJ cord-010119-t1x9gknd 11829 27 blood blood NN cord-010119-t1x9gknd 11829 28 product product NN cord-010119-t1x9gknd 11829 29 wastage wastage NN cord-010119-t1x9gknd 11829 30 . . . cord-010119-t1x9gknd 11830 1 Wastage wastage NN cord-010119-t1x9gknd 11830 2 records record NNS cord-010119-t1x9gknd 11830 3 from from IN cord-010119-t1x9gknd 11830 4 January January NNP cord-010119-t1x9gknd 11830 5 to to IN cord-010119-t1x9gknd 11830 6 April April NNP cord-010119-t1x9gknd 11830 7 2017 2017 CD cord-010119-t1x9gknd 11830 8 were be VBD cord-010119-t1x9gknd 11830 9 reviewed review VBN cord-010119-t1x9gknd 11830 10 , , , cord-010119-t1x9gknd 11830 11 and and CC cord-010119-t1x9gknd 11830 12 wasted waste VBN cord-010119-t1x9gknd 11830 13 products product NNS cord-010119-t1x9gknd 11830 14 that that WDT cord-010119-t1x9gknd 11830 15 were be VBD cord-010119-t1x9gknd 11830 16 considered consider VBN cord-010119-t1x9gknd 11830 17 preventable preventable JJ cord-010119-t1x9gknd 11830 18 were be VBD cord-010119-t1x9gknd 11830 19 investigated investigate VBN cord-010119-t1x9gknd 11830 20 using use VBG cord-010119-t1x9gknd 11830 21 secure secure JJ cord-010119-t1x9gknd 11830 22 texting texting NN cord-010119-t1x9gknd 11830 23 to to TO cord-010119-t1x9gknd 11830 24 communicate communicate VB cord-010119-t1x9gknd 11830 25 with with IN cord-010119-t1x9gknd 11830 26 the the DT cord-010119-t1x9gknd 11830 27 ordering order VBG cord-010119-t1x9gknd 11830 28 physician physician NN cord-010119-t1x9gknd 11830 29 . . . cord-010119-t1x9gknd 11831 1 Results/ Results/ . cord-010119-t1x9gknd 11832 1 Finding finding NN cord-010119-t1x9gknd 11832 2 : : : cord-010119-t1x9gknd 11833 1 For for IN cord-010119-t1x9gknd 11833 2 2016 2016 CD cord-010119-t1x9gknd 11833 3 data datum NNS cord-010119-t1x9gknd 11833 4 , , , cord-010119-t1x9gknd 11833 5 129 129 CD cord-010119-t1x9gknd 11833 6 units unit NNS cord-010119-t1x9gknd 11833 7 were be VBD cord-010119-t1x9gknd 11833 8 investigated investigate VBN cord-010119-t1x9gknd 11833 9 without without IN cord-010119-t1x9gknd 11833 10 the the DT cord-010119-t1x9gknd 11833 11 use use NN cord-010119-t1x9gknd 11833 12 of of IN cord-010119-t1x9gknd 11833 13 secure secure JJ cord-010119-t1x9gknd 11833 14 texting texting NN cord-010119-t1x9gknd 11833 15 . . . cord-010119-t1x9gknd 11834 1 Of of IN cord-010119-t1x9gknd 11834 2 these these DT cord-010119-t1x9gknd 11834 3 , , , cord-010119-t1x9gknd 11834 4 118 118 CD cord-010119-t1x9gknd 11834 5 units unit NNS cord-010119-t1x9gknd 11834 6 were be VBD cord-010119-t1x9gknd 11834 7 identified identify VBN cord-010119-t1x9gknd 11834 8 as as IN cord-010119-t1x9gknd 11834 9 preventable preventable JJ cord-010119-t1x9gknd 11834 10 wastage wastage NN cord-010119-t1x9gknd 11834 11 , , , cord-010119-t1x9gknd 11834 12 and and CC cord-010119-t1x9gknd 11834 13 11 11 CD cord-010119-t1x9gknd 11834 14 wasted waste VBN cord-010119-t1x9gknd 11834 15 units unit NNS cord-010119-t1x9gknd 11834 16 were be VBD cord-010119-t1x9gknd 11834 17 considered consider VBN cord-010119-t1x9gknd 11834 18 beyond beyond IN cord-010119-t1x9gknd 11834 19 the the DT cord-010119-t1x9gknd 11834 20 control control NN cord-010119-t1x9gknd 11834 21 of of IN cord-010119-t1x9gknd 11834 22 the the DT cord-010119-t1x9gknd 11834 23 clinician clinician NN cord-010119-t1x9gknd 11834 24 . . . cord-010119-t1x9gknd 11835 1 The the DT cord-010119-t1x9gknd 11835 2 categories category NNS cord-010119-t1x9gknd 11835 3 for for IN cord-010119-t1x9gknd 11835 4 preventable preventable JJ cord-010119-t1x9gknd 11835 5 wastage wastage NN cord-010119-t1x9gknd 11835 6 were be VBD cord-010119-t1x9gknd 11835 7 defined define VBN cord-010119-t1x9gknd 11835 8 as as IN cord-010119-t1x9gknd 11835 9 follows follow VBZ cord-010119-t1x9gknd 11835 10 : : : cord-010119-t1x9gknd 11836 1 1 1 LS cord-010119-t1x9gknd 11836 2 ) ) -RRB- cord-010119-t1x9gknd 11836 3 Product product NN cord-010119-t1x9gknd 11836 4 not not RB cord-010119-t1x9gknd 11836 5 released release VBN cord-010119-t1x9gknd 11836 6 after after IN cord-010119-t1x9gknd 11836 7 procedure/ procedure/ CD cord-010119-t1x9gknd 11836 8 or or CC cord-010119-t1x9gknd 11836 9 when when WRB cord-010119-t1x9gknd 11836 10 patient patient JJ cord-010119-t1x9gknd 11836 11 stabilized stabilize VBD cord-010119-t1x9gknd 11836 12 ( ( -LRB- cord-010119-t1x9gknd 11836 13 42 42 CD cord-010119-t1x9gknd 11836 14 ) ) -RRB- cord-010119-t1x9gknd 11836 15 2 2 CD cord-010119-t1x9gknd 11836 16 ) ) -RRB- cord-010119-t1x9gknd 11837 1 Product product NN cord-010119-t1x9gknd 11837 2 returned return VBD cord-010119-t1x9gknd 11837 3 outside outside RB cord-010119-t1x9gknd 11837 4 of of IN cord-010119-t1x9gknd 11837 5 appropriate appropriate JJ cord-010119-t1x9gknd 11837 6 temperature temperature NN cord-010119-t1x9gknd 11837 7 range range NN cord-010119-t1x9gknd 11837 8 ( ( -LRB- cord-010119-t1x9gknd 11837 9 40 40 CD cord-010119-t1x9gknd 11837 10 ) ) -RRB- cord-010119-t1x9gknd 11837 11 3 3 CD cord-010119-t1x9gknd 11837 12 ) ) -RRB- cord-010119-t1x9gknd 11838 1 Clinician clinician JJ cord-010119-t1x9gknd 11838 2 unaware unaware JJ cord-010119-t1x9gknd 11838 3 product product NN cord-010119-t1x9gknd 11838 4 was be VBD cord-010119-t1x9gknd 11838 5 assigned assign VBN cord-010119-t1x9gknd 11838 6 ( ( -LRB- cord-010119-t1x9gknd 11838 7 36 36 CD cord-010119-t1x9gknd 11838 8 ) ) -RRB- cord-010119-t1x9gknd 11838 9 . . . cord-010119-t1x9gknd 11839 1 Thus thus RB cord-010119-t1x9gknd 11839 2 far far RB cord-010119-t1x9gknd 11839 3 in in IN cord-010119-t1x9gknd 11839 4 2017 2017 CD cord-010119-t1x9gknd 11839 5 , , , cord-010119-t1x9gknd 11839 6 wastage wastage NN cord-010119-t1x9gknd 11839 7 records record NNS cord-010119-t1x9gknd 11839 8 have have VBP cord-010119-t1x9gknd 11839 9 identified identify VBN cord-010119-t1x9gknd 11839 10 31 31 CD cord-010119-t1x9gknd 11839 11 units unit NNS cord-010119-t1x9gknd 11839 12 of of IN cord-010119-t1x9gknd 11839 13 preventable preventable JJ cord-010119-t1x9gknd 11839 14 wastage wastage NN cord-010119-t1x9gknd 11839 15 . . . cord-010119-t1x9gknd 11840 1 Secure secure JJ cord-010119-t1x9gknd 11840 2 texting texting NN cord-010119-t1x9gknd 11840 3 was be VBD cord-010119-t1x9gknd 11840 4 used use VBN cord-010119-t1x9gknd 11840 5 by by IN cord-010119-t1x9gknd 11840 6 a a DT cord-010119-t1x9gknd 11840 7 Transfusion Transfusion NNP cord-010119-t1x9gknd 11840 8 Service Service NNP cord-010119-t1x9gknd 11840 9 physician physician NN cord-010119-t1x9gknd 11840 10 to to TO cord-010119-t1x9gknd 11840 11 investigate investigate VB cord-010119-t1x9gknd 11840 12 . . . cord-010119-t1x9gknd 11841 1 Twelve twelve CD cord-010119-t1x9gknd 11841 2 responses response NNS cord-010119-t1x9gknd 11841 3 provided provide VBD cord-010119-t1x9gknd 11841 4 useful useful JJ cord-010119-t1x9gknd 11841 5 feedback feedback NN cord-010119-t1x9gknd 11841 6 for for IN cord-010119-t1x9gknd 11841 7 future future JJ cord-010119-t1x9gknd 11841 8 management management NN cord-010119-t1x9gknd 11841 9 strategies strategy NNS cord-010119-t1x9gknd 11841 10 , , , cord-010119-t1x9gknd 11841 11 11 11 CD cord-010119-t1x9gknd 11841 12 responses response NNS cord-010119-t1x9gknd 11841 13 thanked thank VBD cord-010119-t1x9gknd 11841 14 the the DT cord-010119-t1x9gknd 11841 15 Transfusion Transfusion NNP cord-010119-t1x9gknd 11841 16 Service Service NNP cord-010119-t1x9gknd 11841 17 for for IN cord-010119-t1x9gknd 11841 18 the the DT cord-010119-t1x9gknd 11841 19 information information NN cord-010119-t1x9gknd 11841 20 , , , cord-010119-t1x9gknd 11841 21 and and CC cord-010119-t1x9gknd 11841 22 in in IN cord-010119-t1x9gknd 11841 23 8 8 CD cord-010119-t1x9gknd 11841 24 instances instance NNS cord-010119-t1x9gknd 11841 25 , , , cord-010119-t1x9gknd 11841 26 the the DT cord-010119-t1x9gknd 11841 27 message message NN cord-010119-t1x9gknd 11841 28 was be VBD cord-010119-t1x9gknd 11841 29 read read VBN cord-010119-t1x9gknd 11841 30 with with IN cord-010119-t1x9gknd 11841 31 no no DT cord-010119-t1x9gknd 11841 32 reply reply NN cord-010119-t1x9gknd 11841 33 . . . cord-010119-t1x9gknd 11842 1 Conclusion conclusion NN cord-010119-t1x9gknd 11842 2 : : : cord-010119-t1x9gknd 11843 1 Secure secure JJ cord-010119-t1x9gknd 11843 2 text text NN cord-010119-t1x9gknd 11843 3 messaging messaging NN cord-010119-t1x9gknd 11843 4 has have VBZ cord-010119-t1x9gknd 11843 5 the the DT cord-010119-t1x9gknd 11843 6 potential potential NN cord-010119-t1x9gknd 11843 7 to to TO cord-010119-t1x9gknd 11843 8 improve improve VB cord-010119-t1x9gknd 11843 9 communication communication NN cord-010119-t1x9gknd 11843 10 in in IN cord-010119-t1x9gknd 11843 11 Transfusion Transfusion NNP cord-010119-t1x9gknd 11843 12 Medicine Medicine NNP cord-010119-t1x9gknd 11843 13 . . . cord-010119-t1x9gknd 11844 1 It -PRON- PRP cord-010119-t1x9gknd 11844 2 is be VBZ cord-010119-t1x9gknd 11844 3 easy easy JJ cord-010119-t1x9gknd 11844 4 to to TO cord-010119-t1x9gknd 11844 5 use use VB cord-010119-t1x9gknd 11844 6 , , , cord-010119-t1x9gknd 11844 7 HIPAA HIPAA NNP cord-010119-t1x9gknd 11844 8 compliant compliant JJ cord-010119-t1x9gknd 11844 9 , , , cord-010119-t1x9gknd 11844 10 and and CC cord-010119-t1x9gknd 11844 11 helps help VBZ cord-010119-t1x9gknd 11844 12 identify identify VB cord-010119-t1x9gknd 11844 13 strategies strategy NNS cord-010119-t1x9gknd 11844 14 for for IN cord-010119-t1x9gknd 11844 15 reducing reduce VBG cord-010119-t1x9gknd 11844 16 wastage wastage NN cord-010119-t1x9gknd 11844 17 by by IN cord-010119-t1x9gknd 11844 18 improving improve VBG cord-010119-t1x9gknd 11844 19 communication communication NN cord-010119-t1x9gknd 11844 20 and and CC cord-010119-t1x9gknd 11844 21 allowing allow VBG cord-010119-t1x9gknd 11844 22 personalized personalized JJ cord-010119-t1x9gknd 11844 23 educational educational JJ cord-010119-t1x9gknd 11844 24 opportunities opportunity NNS cord-010119-t1x9gknd 11844 25 between between IN cord-010119-t1x9gknd 11844 26 ordering order VBG cord-010119-t1x9gknd 11844 27 physicians physician NNS cord-010119-t1x9gknd 11844 28 and and CC cord-010119-t1x9gknd 11844 29 the the DT cord-010119-t1x9gknd 11844 30 Transfusion Transfusion NNP cord-010119-t1x9gknd 11844 31 Service Service NNP cord-010119-t1x9gknd 11844 32 . . . cord-010119-t1x9gknd 11845 1 Sequence sequence NN cord-010119-t1x9gknd 11845 2 of of IN cord-010119-t1x9gknd 11845 3 Reagent Reagent NNP cord-010119-t1x9gknd 11845 4 Adding add VBG cord-010119-t1x9gknd 11845 5 for for IN cord-010119-t1x9gknd 11845 6 Cryopreservation Cryopreservation NNP cord-010119-t1x9gknd 11845 7 Freezing Freezing NNP cord-010119-t1x9gknd 11845 8 Solution Solution NNP cord-010119-t1x9gknd 11845 9 Guoling Guoling NNP cord-010119-t1x9gknd 11845 10 Chen Chen NNP cord-010119-t1x9gknd 11845 11 * * NFP cord-010119-t1x9gknd 11845 12 , , , cord-010119-t1x9gknd 11845 13 Xu Xu NNP cord-010119-t1x9gknd 11845 14 Zhao Zhao NNP cord-010119-t1x9gknd 11845 15 , , , cord-010119-t1x9gknd 11845 16 Andrew Andrew NNP cord-010119-t1x9gknd 11845 17 Tiss Tiss NNP cord-010119-t1x9gknd 11845 18 , , , cord-010119-t1x9gknd 11845 19 Sasha Sasha NNP cord-010119-t1x9gknd 11845 20 Turner Turner NNP cord-010119-t1x9gknd 11845 21 , , , cord-010119-t1x9gknd 11845 22 Devin Devin NNP cord-010119-t1x9gknd 11845 23 Emerson Emerson NNP cord-010119-t1x9gknd 11845 24 , , , cord-010119-t1x9gknd 11845 25 Manijeh Manijeh NNP cord-010119-t1x9gknd 11845 26 Shemirani Shemirani NNP cord-010119-t1x9gknd 11845 27 , , , cord-010119-t1x9gknd 11845 28 Sharon Sharon NNP cord-010119-t1x9gknd 11845 29 Novak Novak NNP cord-010119-t1x9gknd 11845 30 , , , cord-010119-t1x9gknd 11845 31 David David NNP cord-010119-t1x9gknd 11845 32 Garvin Garvin NNP cord-010119-t1x9gknd 11845 33 , , , cord-010119-t1x9gknd 11845 34 John John NNP cord-010119-t1x9gknd 11845 35 Eng Eng NNP cord-010119-t1x9gknd 11845 36 and and CC cord-010119-t1x9gknd 11845 37 Wanxing Wanxing NNP cord-010119-t1x9gknd 11845 38 Cui Cui NNP cord-010119-t1x9gknd 11845 39 . . . cord-010119-t1x9gknd 11846 1 MedStar MedStar NNP cord-010119-t1x9gknd 11846 2 Georgetown Georgetown NNP cord-010119-t1x9gknd 11846 3 University University NNP cord-010119-t1x9gknd 11846 4 Hospital Hospital NNP cord-010119-t1x9gknd 11846 5 Background Background NNP cord-010119-t1x9gknd 11846 6 / / SYM cord-010119-t1x9gknd 11846 7 Case Case NNP cord-010119-t1x9gknd 11846 8 Studies Studies NNPS cord-010119-t1x9gknd 11846 9 : : : cord-010119-t1x9gknd 11846 10 Dimethyl dimethyl NN cord-010119-t1x9gknd 11846 11 sulfoxide sulfoxide NN cord-010119-t1x9gknd 11846 12 ( ( -LRB- cord-010119-t1x9gknd 11846 13 DMSO DMSO NNP cord-010119-t1x9gknd 11846 14 ) ) -RRB- cord-010119-t1x9gknd 11846 15 , , , cord-010119-t1x9gknd 11846 16 plasmalyte plasmalyte NNP cord-010119-t1x9gknd 11846 17 - - HYPH cord-010119-t1x9gknd 11846 18 A A NNP cord-010119-t1x9gknd 11846 19 ( ( -LRB- cord-010119-t1x9gknd 11846 20 Plas Plas NNP cord-010119-t1x9gknd 11846 21 - - HYPH cord-010119-t1x9gknd 11846 22 A A NNP cord-010119-t1x9gknd 11846 23 ) ) -RRB- cord-010119-t1x9gknd 11846 24 , , , cord-010119-t1x9gknd 11846 25 Human Human NNP cord-010119-t1x9gknd 11846 26 Serum Serum NNP cord-010119-t1x9gknd 11846 27 Albumin Albumin NNP cord-010119-t1x9gknd 11846 28 ( ( -LRB- cord-010119-t1x9gknd 11846 29 HSA HSA NNP cord-010119-t1x9gknd 11846 30 ) ) -RRB- cord-010119-t1x9gknd 11847 1 are be VBP cord-010119-t1x9gknd 11847 2 widely widely RB cord-010119-t1x9gknd 11847 3 used use VBN cord-010119-t1x9gknd 11847 4 to to TO cord-010119-t1x9gknd 11847 5 prepare prepare VB cord-010119-t1x9gknd 11847 6 cryopreservation cryopreservation NN cord-010119-t1x9gknd 11847 7 freezing freeze VBG cord-010119-t1x9gknd 11847 8 solution solution NN cord-010119-t1x9gknd 11847 9 . . . cord-010119-t1x9gknd 11848 1 Some some DT cord-010119-t1x9gknd 11848 2 use use VBP cord-010119-t1x9gknd 11848 3 autologous autologous JJ cord-010119-t1x9gknd 11848 4 plasma plasma NN cord-010119-t1x9gknd 11848 5 instead instead RB cord-010119-t1x9gknd 11848 6 of of IN cord-010119-t1x9gknd 11848 7 Plas Plas NNP cord-010119-t1x9gknd 11848 8 - - HYPH cord-010119-t1x9gknd 11848 9 A A NNP cord-010119-t1x9gknd 11848 10 and and CC cord-010119-t1x9gknd 11848 11 HSA HSA NNP cord-010119-t1x9gknd 11848 12 . . . cord-010119-t1x9gknd 11849 1 This this DT cord-010119-t1x9gknd 11849 2 study study NN cord-010119-t1x9gknd 11849 3 is be VBZ cord-010119-t1x9gknd 11849 4 to to TO cord-010119-t1x9gknd 11849 5 identify identify VB cord-010119-t1x9gknd 11849 6 the the DT cord-010119-t1x9gknd 11849 7 choice choice NN cord-010119-t1x9gknd 11849 8 of of IN cord-010119-t1x9gknd 11849 9 reagents reagent NNS cord-010119-t1x9gknd 11849 10 and and CC cord-010119-t1x9gknd 11849 11 the the DT cord-010119-t1x9gknd 11849 12 optimal optimal JJ cord-010119-t1x9gknd 11849 13 sequence sequence NN cord-010119-t1x9gknd 11849 14 of of IN cord-010119-t1x9gknd 11849 15 adding add VBG cord-010119-t1x9gknd 11849 16 these these DT cord-010119-t1x9gknd 11849 17 reagents reagent NNS cord-010119-t1x9gknd 11849 18 when when WRB cord-010119-t1x9gknd 11849 19 making make VBG cord-010119-t1x9gknd 11849 20 freezing freeze VBG cord-010119-t1x9gknd 11849 21 solution solution NN cord-010119-t1x9gknd 11849 22 . . . cord-010119-t1x9gknd 11850 1 Study Study NNP cord-010119-t1x9gknd 11850 2 Design Design NNP cord-010119-t1x9gknd 11850 3 / / SYM cord-010119-t1x9gknd 11850 4 Methods method NNS cord-010119-t1x9gknd 11850 5 : : : cord-010119-t1x9gknd 11850 6 Materials material NNS cord-010119-t1x9gknd 11850 7 : : : cord-010119-t1x9gknd 11850 8 99.9 99.9 CD cord-010119-t1x9gknd 11850 9 % % NN cord-010119-t1x9gknd 11850 10 DMSO DMSO NNP cord-010119-t1x9gknd 11850 11 , , , cord-010119-t1x9gknd 11850 12 Plas Plas NNP cord-010119-t1x9gknd 11850 13 - - HYPH cord-010119-t1x9gknd 11850 14 A A NNP cord-010119-t1x9gknd 11850 15 , , , cord-010119-t1x9gknd 11850 16 25 25 CD cord-010119-t1x9gknd 11850 17 % % NN cord-010119-t1x9gknd 11850 18 HSA HSA NNP cord-010119-t1x9gknd 11850 19 , , , cord-010119-t1x9gknd 11850 20 autologous autologous JJ cord-010119-t1x9gknd 11850 21 plasma plasma NN cord-010119-t1x9gknd 11850 22 extracted extract VBN cord-010119-t1x9gknd 11850 23 . . . cord-010119-t1x9gknd 11851 1 Containers container NNS cord-010119-t1x9gknd 11851 2 : : : cord-010119-t1x9gknd 11851 3 transfer transfer NN cord-010119-t1x9gknd 11851 4 pack pack NN cord-010119-t1x9gknd 11851 5 ( ( -LRB- cord-010119-t1x9gknd 11851 6 bag bag NN cord-010119-t1x9gknd 11851 7 ) ) -RRB- cord-010119-t1x9gknd 11851 8 and and CC cord-010119-t1x9gknd 11851 9 polystyrene polystyrene NN cord-010119-t1x9gknd 11851 10 tubes tube NNS cord-010119-t1x9gknd 11851 11 . . . cord-010119-t1x9gknd 11852 1 The the DT cord-010119-t1x9gknd 11852 2 Freezing Freezing NNP cord-010119-t1x9gknd 11852 3 Solution Solution NNP cord-010119-t1x9gknd 11852 4 recipe recipe NN cord-010119-t1x9gknd 11852 5 used use VBN cord-010119-t1x9gknd 11852 6 in in IN cord-010119-t1x9gknd 11852 7 this this DT cord-010119-t1x9gknd 11852 8 study study NN cord-010119-t1x9gknd 11852 9 is be VBZ cord-010119-t1x9gknd 11852 10 ( ( -LRB- cord-010119-t1x9gknd 11852 11 volume volume NN cord-010119-t1x9gknd 11852 12 ratio ratio NN cord-010119-t1x9gknd 11852 13 ) ) -RRB- cord-010119-t1x9gknd 11852 14 99.9%DMSO 99.9%dmso CD cord-010119-t1x9gknd 11852 15 : : : cord-010119-t1x9gknd 11853 1 Plas Plas NNP cord-010119-t1x9gknd 11853 2 - - HYPH cord-010119-t1x9gknd 11853 3 A A NNP cord-010119-t1x9gknd 11853 4 : : : cord-010119-t1x9gknd 11853 5 25%HSA51:2:2 25%hsa51:2:2 CD cord-010119-t1x9gknd 11853 6 . . . cord-010119-t1x9gknd 11854 1 Plas Plas NNP cord-010119-t1x9gknd 11854 2 - - HYPH cord-010119-t1x9gknd 11854 3 A A NNP cord-010119-t1x9gknd 11854 4 and and CC cord-010119-t1x9gknd 11854 5 HSA HSA NNP cord-010119-t1x9gknd 11854 6 are be VBP cord-010119-t1x9gknd 11854 7 kept keep VBN cord-010119-t1x9gknd 11854 8 at at IN cord-010119-t1x9gknd 11854 9 room room NN cord-010119-t1x9gknd 11854 10 temperature temperature NN cord-010119-t1x9gknd 11854 11 ( ( -LRB- cord-010119-t1x9gknd 11854 12 20 20 CD cord-010119-t1x9gknd 11854 13 - - SYM cord-010119-t1x9gknd 11854 14 258C 258c CD cord-010119-t1x9gknd 11854 15 , , , cord-010119-t1x9gknd 11854 16 RT RT NNP cord-010119-t1x9gknd 11854 17 ) ) -RRB- cord-010119-t1x9gknd 11854 18 and and CC cord-010119-t1x9gknd 11854 19 refrigerated refrigerate VBN cord-010119-t1x9gknd 11854 20 at at IN cord-010119-t1x9gknd 11854 21 48C 48c CD cord-010119-t1x9gknd 11854 22 , , , cord-010119-t1x9gknd 11854 23 plasma plasma NN cord-010119-t1x9gknd 11854 24 at at IN cord-010119-t1x9gknd 11854 25 RT RT NNP cord-010119-t1x9gknd 11854 26 ( ( -LRB- cord-010119-t1x9gknd 11854 27 to to TO cord-010119-t1x9gknd 11854 28 simulate simulate VB cord-010119-t1x9gknd 11854 29 the the DT cord-010119-t1x9gknd 11854 30 end end NN cord-010119-t1x9gknd 11854 31 - - HYPH cord-010119-t1x9gknd 11854 32 of of IN cord-010119-t1x9gknd 11854 33 - - HYPH cord-010119-t1x9gknd 11854 34 centrifuge centrifuge NN cord-010119-t1x9gknd 11854 35 temperature temperature NN cord-010119-t1x9gknd 11854 36 ) ) -RRB- cord-010119-t1x9gknd 11854 37 , , , cord-010119-t1x9gknd 11854 38 DMSO DMSO NNP cord-010119-t1x9gknd 11854 39 at at IN cord-010119-t1x9gknd 11854 40 RT RT NNP cord-010119-t1x9gknd 11854 41 ( ( -LRB- cord-010119-t1x9gknd 11854 42 due due IN cord-010119-t1x9gknd 11854 43 to to IN cord-010119-t1x9gknd 11854 44 high high JJ cord-010119-t1x9gknd 11854 45 freezing freezing NN cord-010119-t1x9gknd 11854 46 point point NN cord-010119-t1x9gknd 11854 47 18.58C 18.58c CD cord-010119-t1x9gknd 11854 48 ) ) -RRB- cord-010119-t1x9gknd 11854 49 . . . cord-010119-t1x9gknd 11855 1 Different different JJ cord-010119-t1x9gknd 11855 2 combinations combination NNS cord-010119-t1x9gknd 11855 3 of of IN cord-010119-t1x9gknd 11855 4 the the DT cord-010119-t1x9gknd 11855 5 reagents reagent NNS cord-010119-t1x9gknd 11855 6 choice choice NN cord-010119-t1x9gknd 11855 7 , , , cord-010119-t1x9gknd 11855 8 storage storage NN cord-010119-t1x9gknd 11855 9 temperature temperature NN cord-010119-t1x9gknd 11855 10 , , , cord-010119-t1x9gknd 11855 11 adding add VBG cord-010119-t1x9gknd 11855 12 sequence sequence NN cord-010119-t1x9gknd 11855 13 , , , cord-010119-t1x9gknd 11855 14 are be VBP cord-010119-t1x9gknd 11855 15 tested test VBN cord-010119-t1x9gknd 11855 16 with with IN cord-010119-t1x9gknd 11855 17 photo photo NN cord-010119-t1x9gknd 11855 18 taken take VBN cord-010119-t1x9gknd 11855 19 . . . cord-010119-t1x9gknd 11856 1 Total total JJ cord-010119-t1x9gknd 11856 2 14 14 CD cord-010119-t1x9gknd 11856 3 tests test NNS cord-010119-t1x9gknd 11856 4 . . . cord-010119-t1x9gknd 11857 1 At at RB cord-010119-t1x9gknd 11857 2 least least RBS cord-010119-t1x9gknd 11857 3 10 10 CD cord-010119-t1x9gknd 11857 4 minutes minute NNS cord-010119-t1x9gknd 11857 5 cooling cool VBG cord-010119-t1x9gknd 11857 6 after after IN cord-010119-t1x9gknd 11857 7 DMSO DMSO NNP cord-010119-t1x9gknd 11857 8 , , , cord-010119-t1x9gknd 11857 9 before before IN cord-010119-t1x9gknd 11857 10 adding add VBG cord-010119-t1x9gknd 11857 11 the the DT cord-010119-t1x9gknd 11857 12 next next JJ cord-010119-t1x9gknd 11857 13 reagent reagent NN cord-010119-t1x9gknd 11857 14 . . . cord-010119-t1x9gknd 11858 1 See see VB cord-010119-t1x9gknd 11858 2 table table NN cord-010119-t1x9gknd 11858 3 : : : cord-010119-t1x9gknd 11858 4 ( ( -LRB- cord-010119-t1x9gknd 11858 5 1 1 LS cord-010119-t1x9gknd 11858 6 ) ) -RRB- cord-010119-t1x9gknd 11858 7 After after IN cord-010119-t1x9gknd 11858 8 directly directly RB cord-010119-t1x9gknd 11858 9 adding add VBG cord-010119-t1x9gknd 11858 10 99.9 99.9 CD cord-010119-t1x9gknd 11858 11 % % NN cord-010119-t1x9gknd 11858 12 DMSO DMSO NNP cord-010119-t1x9gknd 11858 13 alone alone JJ cord-010119-t1x9gknd 11858 14 to to TO cord-010119-t1x9gknd 11858 15 bag bag VB cord-010119-t1x9gknd 11858 16 , , , cord-010119-t1x9gknd 11858 17 the the DT cord-010119-t1x9gknd 11858 18 bag bag NN cord-010119-t1x9gknd 11858 19 turned turn VBD cord-010119-t1x9gknd 11858 20 from from IN cord-010119-t1x9gknd 11858 21 transparent transparent JJ cord-010119-t1x9gknd 11858 22 to to IN cord-010119-t1x9gknd 11858 23 white white JJ cord-010119-t1x9gknd 11858 24 , , , cord-010119-t1x9gknd 11858 25 so so IN cord-010119-t1x9gknd 11858 26 DMSO DMSO NNP cord-010119-t1x9gknd 11858 27 should should MD cord-010119-t1x9gknd 11858 28 not not RB cord-010119-t1x9gknd 11858 29 add add VB cord-010119-t1x9gknd 11858 30 first first RB cord-010119-t1x9gknd 11858 31 . . . cord-010119-t1x9gknd 11859 1 ( ( -LRB- cord-010119-t1x9gknd 11859 2 2 2 LS cord-010119-t1x9gknd 11859 3 ) ) -RRB- cord-010119-t1x9gknd 11860 1 In in IN cord-010119-t1x9gknd 11860 2 tube tube NN cord-010119-t1x9gknd 11860 3 , , , cord-010119-t1x9gknd 11860 4 autologous autologous JJ cord-010119-t1x9gknd 11860 5 plasma plasma NN cord-010119-t1x9gknd 11860 6 first first RB cord-010119-t1x9gknd 11860 7 , , , cord-010119-t1x9gknd 11860 8 DMSO DMSO NNP cord-010119-t1x9gknd 11860 9 next next RB cord-010119-t1x9gknd 11860 10 , , , cord-010119-t1x9gknd 11860 11 powder powder NN cord-010119-t1x9gknd 11860 12 - - HYPH cord-010119-t1x9gknd 11860 13 like like JJ cord-010119-t1x9gknd 11860 14 precipitates precipitate NNS cord-010119-t1x9gknd 11860 15 . . . cord-010119-t1x9gknd 11860 16 _SP cord-010119-t1x9gknd 11861 1 ( ( -LRB- cord-010119-t1x9gknd 11861 2 3 3 LS cord-010119-t1x9gknd 11861 3 ) ) -RRB- cord-010119-t1x9gknd 11862 1 In in IN cord-010119-t1x9gknd 11862 2 tube tube NN cord-010119-t1x9gknd 11862 3 , , , cord-010119-t1x9gknd 11862 4 DMSO DMSO NNP cord-010119-t1x9gknd 11862 5 first first RB cord-010119-t1x9gknd 11862 6 , , , cord-010119-t1x9gknd 11862 7 HSA HSA NNP cord-010119-t1x9gknd 11862 8 next next RB cord-010119-t1x9gknd 11862 9 , , , cord-010119-t1x9gknd 11862 10 precipitated precipitate VBD cord-010119-t1x9gknd 11862 11 instantly instantly RB cord-010119-t1x9gknd 11862 12 , , , cord-010119-t1x9gknd 11862 13 a a DT cord-010119-t1x9gknd 11862 14 layered layered JJ cord-010119-t1x9gknd 11862 15 appearance appearance NN cord-010119-t1x9gknd 11862 16 . . . cord-010119-t1x9gknd 11863 1 ( ( -LRB- cord-010119-t1x9gknd 11863 2 4 4 LS cord-010119-t1x9gknd 11863 3 ) ) -RRB- cord-010119-t1x9gknd 11863 4 & & CC cord-010119-t1x9gknd 11863 5 ( ( -LRB- cord-010119-t1x9gknd 11863 6 5 5 LS cord-010119-t1x9gknd 11863 7 ) ) -RRB- cord-010119-t1x9gknd 11864 1 In in IN cord-010119-t1x9gknd 11864 2 tube tube NN cord-010119-t1x9gknd 11864 3 , , , cord-010119-t1x9gknd 11864 4 Plas Plas NNP cord-010119-t1x9gknd 11864 5 - - HYPH cord-010119-t1x9gknd 11864 6 A A NNP cord-010119-t1x9gknd 11864 7 first first JJ cord-010119-t1x9gknd 11864 8 , , , cord-010119-t1x9gknd 11864 9 then then RB cord-010119-t1x9gknd 11864 10 HSA HSA NNP cord-010119-t1x9gknd 11864 11 , , , cord-010119-t1x9gknd 11864 12 DMSO DMSO NNP cord-010119-t1x9gknd 11864 13 at at IN cord-010119-t1x9gknd 11864 14 last last JJ cord-010119-t1x9gknd 11864 15 , , , cord-010119-t1x9gknd 11864 16 precipitates precipitate VBZ cord-010119-t1x9gknd 11864 17 formed form VBN cord-010119-t1x9gknd 11864 18 ; ; : cord-010119-t1x9gknd 11864 19 RT RT NNP cord-010119-t1x9gknd 11864 20 Plas Plas NNP cord-010119-t1x9gknd 11864 21 - - HYPH cord-010119-t1x9gknd 11864 22 A A NNP cord-010119-t1x9gknd 11864 23 and and CC cord-010119-t1x9gknd 11864 24 HSA HSA NNP cord-010119-t1x9gknd 11864 25 combination combination NN cord-010119-t1x9gknd 11864 26 formed form VBD cord-010119-t1x9gknd 11864 27 a a DT cord-010119-t1x9gknd 11864 28 thicker thick JJR cord-010119-t1x9gknd 11864 29 precipitate precipitate NN cord-010119-t1x9gknd 11864 30 than than IN cord-010119-t1x9gknd 11864 31 those those DT cord-010119-t1x9gknd 11864 32 kept keep VBN cord-010119-t1x9gknd 11864 33 at at IN cord-010119-t1x9gknd 11864 34 48C. 48c. CD cord-010119-t1x9gknd 11864 35 ( ( -LRB- cord-010119-t1x9gknd 11864 36 6)&(7 6)&(7 CD cord-010119-t1x9gknd 11864 37 ) ) -RRB- cord-010119-t1x9gknd 11865 1 In in IN cord-010119-t1x9gknd 11865 2 tube tube NN cord-010119-t1x9gknd 11865 3 , , , cord-010119-t1x9gknd 11865 4 HSA HSA NNP cord-010119-t1x9gknd 11865 5 first first RB cord-010119-t1x9gknd 11865 6 , , , cord-010119-t1x9gknd 11865 7 DMSO DMSO NNP cord-010119-t1x9gknd 11865 8 next next RB cord-010119-t1x9gknd 11865 9 : : : cord-010119-t1x9gknd 11866 1 precipitation precipitation NN cord-010119-t1x9gknd 11866 2 formed form VBN cord-010119-t1x9gknd 11866 3 heavily heavily RB cord-010119-t1x9gknd 11866 4 , , , cord-010119-t1x9gknd 11866 5 sculpture sculpture NN cord-010119-t1x9gknd 11866 6 shape shape NN cord-010119-t1x9gknd 11866 7 . . . cord-010119-t1x9gknd 11867 1 Precipitation precipitation NN cord-010119-t1x9gknd 11867 2 in in IN cord-010119-t1x9gknd 11867 3 the the DT cord-010119-t1x9gknd 11867 4 48C 48c CD cord-010119-t1x9gknd 11867 5 group group NN cord-010119-t1x9gknd 11867 6 is be VBZ cord-010119-t1x9gknd 11867 7 slightly slightly RB cord-010119-t1x9gknd 11867 8 milder mild JJR cord-010119-t1x9gknd 11867 9 / / SYM cord-010119-t1x9gknd 11867 10 slower slow JJR cord-010119-t1x9gknd 11867 11 than than IN cord-010119-t1x9gknd 11867 12 RT RT NNP cord-010119-t1x9gknd 11867 13 group group NN cord-010119-t1x9gknd 11867 14 . . . cord-010119-t1x9gknd 11868 1 So so IN cord-010119-t1x9gknd 11868 2 HSA HSA NNP cord-010119-t1x9gknd 11868 3 should should MD cord-010119-t1x9gknd 11868 4 not not RB cord-010119-t1x9gknd 11868 5 be be VB cord-010119-t1x9gknd 11868 6 added add VBN cord-010119-t1x9gknd 11868 7 first first RB cord-010119-t1x9gknd 11868 8 . . . cord-010119-t1x9gknd 11869 1 ( ( -LRB- cord-010119-t1x9gknd 11869 2 8)&(9 8)&(9 CD cord-010119-t1x9gknd 11869 3 ) ) -RRB- cord-010119-t1x9gknd 11869 4 Trace trace NN cord-010119-t1x9gknd 11869 5 of of IN cord-010119-t1x9gknd 11869 6 HSA(<1ml HSA(<1ml NNP cord-010119-t1x9gknd 11869 7 ) ) -RRB- cord-010119-t1x9gknd 11869 8 was be VBD cord-010119-t1x9gknd 11869 9 mixed mix VBN cord-010119-t1x9gknd 11869 10 into into IN cord-010119-t1x9gknd 11869 11 the the DT cord-010119-t1x9gknd 11869 12 Plas Plas NNP cord-010119-t1x9gknd 11869 13 - - HYPH cord-010119-t1x9gknd 11869 14 A A NNP cord-010119-t1x9gknd 11869 15 bag bag NN cord-010119-t1x9gknd 11869 16 ( ( -LRB- cord-010119-t1x9gknd 11869 17 500ml 500ml NNP cord-010119-t1x9gknd 11869 18 ) ) -RRB- cord-010119-t1x9gknd 11869 19 . . . cord-010119-t1x9gknd 11870 1 In in IN cord-010119-t1x9gknd 11870 2 tube tube NN cord-010119-t1x9gknd 11870 3 , , , cord-010119-t1x9gknd 11870 4 such such JJ cord-010119-t1x9gknd 11870 5 " " `` cord-010119-t1x9gknd 11870 6 HSA HSA NNP cord-010119-t1x9gknd 11870 7 - - HYPH cord-010119-t1x9gknd 11870 8 contaminated contaminate VBN cord-010119-t1x9gknd 11870 9 " " `` cord-010119-t1x9gknd 11870 10 Plas Plas NNP cord-010119-t1x9gknd 11870 11 - - HYPH cord-010119-t1x9gknd 11870 12 A A NNP cord-010119-t1x9gknd 11870 13 was be VBD cord-010119-t1x9gknd 11870 14 added add VBN cord-010119-t1x9gknd 11870 15 first first RB cord-010119-t1x9gknd 11870 16 , , , cord-010119-t1x9gknd 11870 17 then then RB cord-010119-t1x9gknd 11870 18 DMSO DMSO NNP cord-010119-t1x9gknd 11870 19 , , , cord-010119-t1x9gknd 11870 20 small small JJ cord-010119-t1x9gknd 11870 21 fragments fragment NNS cord-010119-t1x9gknd 11870 22 of of IN cord-010119-t1x9gknd 11870 23 precipitates precipitate NNS cord-010119-t1x9gknd 11870 24 formed form VBN cord-010119-t1x9gknd 11870 25 , , , cord-010119-t1x9gknd 11870 26 so so IN cord-010119-t1x9gknd 11870 27 DMSO DMSO NNP cord-010119-t1x9gknd 11870 28 should should MD cord-010119-t1x9gknd 11870 29 not not RB cord-010119-t1x9gknd 11870 30 add add VB cord-010119-t1x9gknd 11870 31 last last RB cord-010119-t1x9gknd 11870 32 . . . cord-010119-t1x9gknd 11871 1 Background Background NNP cord-010119-t1x9gknd 11871 2 / / SYM cord-010119-t1x9gknd 11871 3 Case Case NNP cord-010119-t1x9gknd 11871 4 Studies Studies NNPS cord-010119-t1x9gknd 11871 5 : : : cord-010119-t1x9gknd 11871 6 Maintaining maintain VBG cord-010119-t1x9gknd 11871 7 a a DT cord-010119-t1x9gknd 11871 8 robust robust JJ cord-010119-t1x9gknd 11871 9 blood blood NN cord-010119-t1x9gknd 11871 10 product product NN cord-010119-t1x9gknd 11871 11 supply supply NN cord-010119-t1x9gknd 11871 12 is be VBZ cord-010119-t1x9gknd 11871 13 an an DT cord-010119-t1x9gknd 11871 14 essential essential JJ cord-010119-t1x9gknd 11871 15 requirement requirement NN cord-010119-t1x9gknd 11871 16 to to TO cord-010119-t1x9gknd 11871 17 guarantee guarantee VB cord-010119-t1x9gknd 11871 18 optimal optimal JJ cord-010119-t1x9gknd 11871 19 patient patient NN cord-010119-t1x9gknd 11871 20 care care NN cord-010119-t1x9gknd 11871 21 for for IN cord-010119-t1x9gknd 11871 22 all all DT cord-010119-t1x9gknd 11871 23 major major JJ cord-010119-t1x9gknd 11871 24 hospitals hospital NNS cord-010119-t1x9gknd 11871 25 . . . cord-010119-t1x9gknd 11872 1 However however RB cord-010119-t1x9gknd 11872 2 , , , cord-010119-t1x9gknd 11872 3 daily daily JJ cord-010119-t1x9gknd 11872 4 blood blood NN cord-010119-t1x9gknd 11872 5 product product NN cord-010119-t1x9gknd 11872 6 use use NN cord-010119-t1x9gknd 11872 7 is be VBZ cord-010119-t1x9gknd 11872 8 difficult difficult JJ cord-010119-t1x9gknd 11872 9 to to TO cord-010119-t1x9gknd 11872 10 anticipate anticipate VB cord-010119-t1x9gknd 11872 11 . . . cord-010119-t1x9gknd 11873 1 Platelet platelet NN cord-010119-t1x9gknd 11873 2 products product NNS cord-010119-t1x9gknd 11873 3 are be VBP cord-010119-t1x9gknd 11873 4 the the DT cord-010119-t1x9gknd 11873 5 most most RBS cord-010119-t1x9gknd 11873 6 variable variable JJ cord-010119-t1x9gknd 11873 7 in in IN cord-010119-t1x9gknd 11873 8 daily daily JJ cord-010119-t1x9gknd 11873 9 usage usage NN cord-010119-t1x9gknd 11873 10 , , , cord-010119-t1x9gknd 11873 11 have have VBP cord-010119-t1x9gknd 11873 12 short short JJ cord-010119-t1x9gknd 11873 13 shelf shelf NN cord-010119-t1x9gknd 11873 14 lives life NNS cord-010119-t1x9gknd 11873 15 , , , cord-010119-t1x9gknd 11873 16 and and CC cord-010119-t1x9gknd 11873 17 are be VBP cord-010119-t1x9gknd 11873 18 also also RB cord-010119-t1x9gknd 11873 19 one one CD cord-010119-t1x9gknd 11873 20 of of IN cord-010119-t1x9gknd 11873 21 the the DT cord-010119-t1x9gknd 11873 22 more more RBR cord-010119-t1x9gknd 11873 23 expensive expensive JJ cord-010119-t1x9gknd 11873 24 products product NNS cord-010119-t1x9gknd 11873 25 to to TO cord-010119-t1x9gknd 11873 26 produce produce VB cord-010119-t1x9gknd 11873 27 , , , cord-010119-t1x9gknd 11873 28 test test VB cord-010119-t1x9gknd 11873 29 , , , cord-010119-t1x9gknd 11873 30 and and CC cord-010119-t1x9gknd 11873 31 store store NN cord-010119-t1x9gknd 11873 32 . . . cord-010119-t1x9gknd 11874 1 Due due IN cord-010119-t1x9gknd 11874 2 to to IN cord-010119-t1x9gknd 11874 3 the the DT cord-010119-t1x9gknd 11874 4 combination combination NN cord-010119-t1x9gknd 11874 5 of of IN cord-010119-t1x9gknd 11874 6 absolute absolute JJ cord-010119-t1x9gknd 11874 7 need need NN cord-010119-t1x9gknd 11874 8 , , , cord-010119-t1x9gknd 11874 9 uncertain uncertain JJ cord-010119-t1x9gknd 11874 10 daily daily JJ cord-010119-t1x9gknd 11874 11 demand demand NN cord-010119-t1x9gknd 11874 12 , , , cord-010119-t1x9gknd 11874 13 and and CC cord-010119-t1x9gknd 11874 14 short short JJ cord-010119-t1x9gknd 11874 15 shelflife shelflife NNP cord-010119-t1x9gknd 11874 16 , , , cord-010119-t1x9gknd 11874 17 platelet platelet NN cord-010119-t1x9gknd 11874 18 products product NNS cord-010119-t1x9gknd 11874 19 are be VBP cord-010119-t1x9gknd 11874 20 also also RB cord-010119-t1x9gknd 11874 21 frequently frequently RB cord-010119-t1x9gknd 11874 22 wasted waste VBN cord-010119-t1x9gknd 11874 23 due due IN cord-010119-t1x9gknd 11874 24 to to IN cord-010119-t1x9gknd 11874 25 expiration expiration NN cord-010119-t1x9gknd 11874 26 . . . cord-010119-t1x9gknd 11875 1 Sophisticated sophisticated JJ cord-010119-t1x9gknd 11875 2 data datum NNS cord-010119-t1x9gknd 11875 3 analysis analysis NN cord-010119-t1x9gknd 11875 4 has have VBZ cord-010119-t1x9gknd 11875 5 the the DT cord-010119-t1x9gknd 11875 6 potential potential NN cord-010119-t1x9gknd 11875 7 to to TO cord-010119-t1x9gknd 11875 8 accurately accurately RB cord-010119-t1x9gknd 11875 9 predict predict VB cord-010119-t1x9gknd 11875 10 hospital hospital NN cord-010119-t1x9gknd 11875 11 wide wide JJ cord-010119-t1x9gknd 11875 12 platelet platelet NN cord-010119-t1x9gknd 11875 13 needs need NNS cord-010119-t1x9gknd 11875 14 and and CC cord-010119-t1x9gknd 11875 15 therefor therefor RB cord-010119-t1x9gknd 11875 16 reduce reduce VB cord-010119-t1x9gknd 11875 17 wastage wastage NN cord-010119-t1x9gknd 11875 18 . . . cord-010119-t1x9gknd 11876 1 Study Study NNP cord-010119-t1x9gknd 11876 2 Design Design NNP cord-010119-t1x9gknd 11876 3 / / SYM cord-010119-t1x9gknd 11876 4 Method method NN cord-010119-t1x9gknd 11876 5 : : : cord-010119-t1x9gknd 11876 6 We -PRON- PRP cord-010119-t1x9gknd 11876 7 have have VBP cord-010119-t1x9gknd 11876 8 investigated investigate VBN cord-010119-t1x9gknd 11876 9 platelet platelet NN cord-010119-t1x9gknd 11876 10 usage usage NN cord-010119-t1x9gknd 11876 11 patterns pattern NNS cord-010119-t1x9gknd 11876 12 at at IN cord-010119-t1x9gknd 11876 13 our -PRON- PRP$ cord-010119-t1x9gknd 11876 14 institution institution NN cord-010119-t1x9gknd 11876 15 , , , cord-010119-t1x9gknd 11876 16 and and CC cord-010119-t1x9gknd 11876 17 specifically specifically RB cord-010119-t1x9gknd 11876 18 interrogated interrogate VBD cord-010119-t1x9gknd 11876 19 the the DT cord-010119-t1x9gknd 11876 20 relationship relationship NN cord-010119-t1x9gknd 11876 21 between between IN cord-010119-t1x9gknd 11876 22 platelet platelet NN cord-010119-t1x9gknd 11876 23 usage usage NN cord-010119-t1x9gknd 11876 24 and and CC cord-010119-t1x9gknd 11876 25 aggregated aggregated JJ cord-010119-t1x9gknd 11876 26 hospital hospital NN cord-010119-t1x9gknd 11876 27 - - HYPH cord-010119-t1x9gknd 11876 28 wide wide JJ cord-010119-t1x9gknd 11876 29 patient patient JJ cord-010119-t1x9gknd 11876 30 data datum NNS cord-010119-t1x9gknd 11876 31 over over IN cord-010119-t1x9gknd 11876 32 a a DT cord-010119-t1x9gknd 11876 33 recent recent JJ cord-010119-t1x9gknd 11876 34 consecutive consecutive JJ cord-010119-t1x9gknd 11876 35 29-month 29-month JJ cord-010119-t1x9gknd 11876 36 period period NN cord-010119-t1x9gknd 11876 37 . . . cord-010119-t1x9gknd 11877 1 Using use VBG cord-010119-t1x9gknd 11877 2 a a DT cord-010119-t1x9gknd 11877 3 convex convex JJ cord-010119-t1x9gknd 11877 4 statistical statistical JJ cord-010119-t1x9gknd 11877 5 formulation formulation NN cord-010119-t1x9gknd 11877 6 , , , cord-010119-t1x9gknd 11877 7 we -PRON- PRP cord-010119-t1x9gknd 11877 8 have have VBP cord-010119-t1x9gknd 11877 9 found find VBN cord-010119-t1x9gknd 11877 10 that that IN cord-010119-t1x9gknd 11877 11 platelet platelet NN cord-010119-t1x9gknd 11877 12 usage usage NN cord-010119-t1x9gknd 11877 13 is be VBZ cord-010119-t1x9gknd 11877 14 highly highly RB cord-010119-t1x9gknd 11877 15 dependent dependent JJ cord-010119-t1x9gknd 11877 16 on on IN cord-010119-t1x9gknd 11877 17 several several JJ cord-010119-t1x9gknd 11877 18 factors factor NNS cord-010119-t1x9gknd 11877 19 . . . cord-010119-t1x9gknd 11878 1 These these DT cord-010119-t1x9gknd 11878 2 include include VBP cord-010119-t1x9gknd 11878 3 day day NN cord-010119-t1x9gknd 11878 4 of of IN cord-010119-t1x9gknd 11878 5 week week NN cord-010119-t1x9gknd 11878 6 , , , cord-010119-t1x9gknd 11878 7 number number NN cord-010119-t1x9gknd 11878 8 of of IN cord-010119-t1x9gknd 11878 9 abnormal abnormal JJ cord-010119-t1x9gknd 11878 10 CBC CBC NNP cord-010119-t1x9gknd 11878 11 , , , cord-010119-t1x9gknd 11878 12 location location NN cord-010119-t1x9gknd 11878 13 - - HYPH cord-010119-t1x9gknd 11878 14 specific specific JJ cord-010119-t1x9gknd 11878 15 hospital hospital NN cord-010119-t1x9gknd 11878 16 census census NN cord-010119-t1x9gknd 11878 17 data datum NNS cord-010119-t1x9gknd 11878 18 , , , cord-010119-t1x9gknd 11878 19 and and CC cord-010119-t1x9gknd 11878 20 other other JJ cord-010119-t1x9gknd 11878 21 less less RBR cord-010119-t1x9gknd 11878 22 important important JJ cord-010119-t1x9gknd 11878 23 factors factor NNS cord-010119-t1x9gknd 11878 24 . . . cord-010119-t1x9gknd 11879 1 We -PRON- PRP cord-010119-t1x9gknd 11879 2 exploited exploit VBD cord-010119-t1x9gknd 11879 3 this this DT cord-010119-t1x9gknd 11879 4 relationship relationship NN cord-010119-t1x9gknd 11879 5 to to TO cord-010119-t1x9gknd 11879 6 develop develop VB cord-010119-t1x9gknd 11879 7 a a DT cord-010119-t1x9gknd 11879 8 mathematical mathematical JJ cord-010119-t1x9gknd 11879 9 model model NN cord-010119-t1x9gknd 11879 10 to to TO cord-010119-t1x9gknd 11879 11 guide guide VB cord-010119-t1x9gknd 11879 12 collection collection NN cord-010119-t1x9gknd 11879 13 and and CC cord-010119-t1x9gknd 11879 14 ordering ordering NN cord-010119-t1x9gknd 11879 15 strategy strategy NN cord-010119-t1x9gknd 11879 16 . . . cord-010119-t1x9gknd 11880 1 Results/ Results/ . cord-010119-t1x9gknd 11881 1 Finding finding NN cord-010119-t1x9gknd 11881 2 : : : cord-010119-t1x9gknd 11882 1 This this DT cord-010119-t1x9gknd 11882 2 model model NN cord-010119-t1x9gknd 11882 3 minimizes minimize VBZ cord-010119-t1x9gknd 11882 4 waste waste NN cord-010119-t1x9gknd 11882 5 due due IN cord-010119-t1x9gknd 11882 6 to to IN cord-010119-t1x9gknd 11882 7 expiration expiration NN cord-010119-t1x9gknd 11882 8 while while IN cord-010119-t1x9gknd 11882 9 never never RB cord-010119-t1x9gknd 11882 10 allowing allow VBG cord-010119-t1x9gknd 11882 11 for for IN cord-010119-t1x9gknd 11882 12 a a DT cord-010119-t1x9gknd 11882 13 shortage shortage NN cord-010119-t1x9gknd 11882 14 ; ; : cord-010119-t1x9gknd 11882 15 the the DT cord-010119-t1x9gknd 11882 16 number number NN cord-010119-t1x9gknd 11882 17 of of IN cord-010119-t1x9gknd 11882 18 remaining remain VBG cord-010119-t1x9gknd 11882 19 platelet platelet NN cord-010119-t1x9gknd 11882 20 units unit NNS cord-010119-t1x9gknd 11882 21 at at IN cord-010119-t1x9gknd 11882 22 the the DT cord-010119-t1x9gknd 11882 23 end end NN cord-010119-t1x9gknd 11882 24 of of IN cord-010119-t1x9gknd 11882 25 any any DT cord-010119-t1x9gknd 11882 26 day day NN cord-010119-t1x9gknd 11882 27 never never RB cord-010119-t1x9gknd 11882 28 drops drop VBZ cord-010119-t1x9gknd 11882 29 below below IN cord-010119-t1x9gknd 11882 30 10 10 CD cord-010119-t1x9gknd 11882 31 in in IN cord-010119-t1x9gknd 11882 32 our -PRON- PRP$ cord-010119-t1x9gknd 11882 33 model model NN cord-010119-t1x9gknd 11882 34 . . . cord-010119-t1x9gknd 11883 1 Compared compare VBN cord-010119-t1x9gknd 11883 2 with with IN cord-010119-t1x9gknd 11883 3 historical historical JJ cord-010119-t1x9gknd 11883 4 expiration expiration NN cord-010119-t1x9gknd 11883 5 rates rate NNS cord-010119-t1x9gknd 11883 6 during during IN cord-010119-t1x9gknd 11883 7 the the DT cord-010119-t1x9gknd 11883 8 same same JJ cord-010119-t1x9gknd 11883 9 period period NN cord-010119-t1x9gknd 11883 10 , , , cord-010119-t1x9gknd 11883 11 our -PRON- PRP$ cord-010119-t1x9gknd 11883 12 model model NN cord-010119-t1x9gknd 11883 13 reduces reduce VBZ cord-010119-t1x9gknd 11883 14 the the DT cord-010119-t1x9gknd 11883 15 expiration expiration NN cord-010119-t1x9gknd 11883 16 rate rate NN cord-010119-t1x9gknd 11883 17 from from IN cord-010119-t1x9gknd 11883 18 10.5 10.5 CD cord-010119-t1x9gknd 11883 19 % % NN cord-010119-t1x9gknd 11883 20 to to IN cord-010119-t1x9gknd 11883 21 3.2 3.2 CD cord-010119-t1x9gknd 11883 22 % % NN cord-010119-t1x9gknd 11883 23 . . . cord-010119-t1x9gknd 11884 1 With with IN cord-010119-t1x9gknd 11884 2 an an DT cord-010119-t1x9gknd 11884 3 annual annual JJ cord-010119-t1x9gknd 11884 4 platelet platelet NN cord-010119-t1x9gknd 11884 5 usage usage NN cord-010119-t1x9gknd 11884 6 of of IN cord-010119-t1x9gknd 11884 7 approximately approximately RB cord-010119-t1x9gknd 11884 8 13,000 13,000 CD cord-010119-t1x9gknd 11884 9 units unit NNS cord-010119-t1x9gknd 11884 10 , , , cord-010119-t1x9gknd 11884 11 this this DT cord-010119-t1x9gknd 11884 12 reduction reduction NN cord-010119-t1x9gknd 11884 13 equates equate VBZ cord-010119-t1x9gknd 11884 14 to to IN cord-010119-t1x9gknd 11884 15 approximately approximately RB cord-010119-t1x9gknd 11884 16 950 950 CD cord-010119-t1x9gknd 11884 17 units unit NNS cord-010119-t1x9gknd 11884 18 saved save VBN cord-010119-t1x9gknd 11884 19 from from IN cord-010119-t1x9gknd 11884 20 expiration expiration NN cord-010119-t1x9gknd 11884 21 annually annually RB cord-010119-t1x9gknd 11884 22 . . . cord-010119-t1x9gknd 11885 1 Depending depend VBG cord-010119-t1x9gknd 11885 2 on on IN cord-010119-t1x9gknd 11885 3 platelet platelet NN cord-010119-t1x9gknd 11885 4 pricing pricing NN cord-010119-t1x9gknd 11885 5 in in IN cord-010119-t1x9gknd 11885 6 different different JJ cord-010119-t1x9gknd 11885 7 regions region NNS cord-010119-t1x9gknd 11885 8 , , , cord-010119-t1x9gknd 11885 9 this this DT cord-010119-t1x9gknd 11885 10 accounts account VBZ cord-010119-t1x9gknd 11885 11 for for IN cord-010119-t1x9gknd 11885 12 annual annual JJ cord-010119-t1x9gknd 11885 13 savings saving NNS cord-010119-t1x9gknd 11885 14 between between IN cord-010119-t1x9gknd 11885 15 $ $ $ cord-010119-t1x9gknd 11885 16 450,000 450,000 CD cord-010119-t1x9gknd 11885 17 to to TO cord-010119-t1x9gknd 11885 18 $ $ $ cord-010119-t1x9gknd 11885 19 650,000 650,000 CD cord-010119-t1x9gknd 11885 20 , , , cord-010119-t1x9gknd 11885 21 per per IN cord-010119-t1x9gknd 11885 22 institution institution NN cord-010119-t1x9gknd 11885 23 . . . cord-010119-t1x9gknd 11886 1 Conclusion conclusion NN cord-010119-t1x9gknd 11886 2 : : : cord-010119-t1x9gknd 11887 1 To to IN cord-010119-t1x9gknd 11887 2 our -PRON- PRP$ cord-010119-t1x9gknd 11887 3 knowledge knowledge NN cord-010119-t1x9gknd 11887 4 our -PRON- PRP$ cord-010119-t1x9gknd 11887 5 research research NN cord-010119-t1x9gknd 11887 6 is be VBZ cord-010119-t1x9gknd 11887 7 the the DT cord-010119-t1x9gknd 11887 8 first first JJ cord-010119-t1x9gknd 11887 9 such such JJ cord-010119-t1x9gknd 11887 10 use use NN cord-010119-t1x9gknd 11887 11 of of IN cord-010119-t1x9gknd 11887 12 hospital hospital NN cord-010119-t1x9gknd 11887 13 wide wide JJ cord-010119-t1x9gknd 11887 14 data datum NNS cord-010119-t1x9gknd 11887 15 to to TO cord-010119-t1x9gknd 11887 16 inform inform VB cord-010119-t1x9gknd 11887 17 real real JJ cord-010119-t1x9gknd 11887 18 - - HYPH cord-010119-t1x9gknd 11887 19 time time NN cord-010119-t1x9gknd 11887 20 donor donor NN cord-010119-t1x9gknd 11887 21 recruitment recruitment NN cord-010119-t1x9gknd 11887 22 strategies strategy NNS cord-010119-t1x9gknd 11887 23 based base VBN cord-010119-t1x9gknd 11887 24 on on IN cord-010119-t1x9gknd 11887 25 anticipated anticipate VBN cord-010119-t1x9gknd 11887 26 patient patient JJ cord-010119-t1x9gknd 11887 27 demand demand NN cord-010119-t1x9gknd 11887 28 . . . cord-010119-t1x9gknd 11888 1 Thawed Thawed NNP cord-010119-t1x9gknd 11888 2 Plasma plasma NN cord-010119-t1x9gknd 11888 3 Implementation implementation NN cord-010119-t1x9gknd 11888 4 : : : cord-010119-t1x9gknd 11888 5 Signficant signficant JJ cord-010119-t1x9gknd 11888 6 Cost Cost NNP cord-010119-t1x9gknd 11888 7 Savings saving NNS cord-010119-t1x9gknd 11888 8 and and CC cord-010119-t1x9gknd 11888 9 Decreased Decreased NNP cord-010119-t1x9gknd 11888 10 Plasma Plasma NNP cord-010119-t1x9gknd 11888 11 Wastage Wastage NNP cord-010119-t1x9gknd 11888 12 Morvarid Morvarid NNP cord-010119-t1x9gknd 11888 13 Moayeri Moayeri NNP cord-010119-t1x9gknd 11888 14 * * NFP cord-010119-t1x9gknd 11888 15 1 1 CD cord-010119-t1x9gknd 11888 16 , , , cord-010119-t1x9gknd 11888 17 Russell Russell NNP cord-010119-t1x9gknd 11888 18 Thorsen Thorsen NNP cord-010119-t1x9gknd 11888 19 1 1 CD cord-010119-t1x9gknd 11888 20 , , , cord-010119-t1x9gknd 11888 21 Rosaline Rosaline NNP cord-010119-t1x9gknd 11888 22 Ma Ma NNP cord-010119-t1x9gknd 11888 23 1 1 CD cord-010119-t1x9gknd 11888 24 , , , cord-010119-t1x9gknd 11888 25 Antonio Antonio NNP cord-010119-t1x9gknd 11888 26 G G NNP cord-010119-t1x9gknd 11888 27 Insigne Insigne NNP cord-010119-t1x9gknd 11888 28 1 1 CD cord-010119-t1x9gknd 11888 29 , , , cord-010119-t1x9gknd 11888 30 Amy Amy NNP cord-010119-t1x9gknd 11888 31 DeCourten DeCourten NNP cord-010119-t1x9gknd 11888 32 1 1 CD cord-010119-t1x9gknd 11888 33 , , , cord-010119-t1x9gknd 11888 34 Florence Florence NNP cord-010119-t1x9gknd 11888 35 Panganiban Panganiban NNP cord-010119-t1x9gknd 11888 36 1 1 CD cord-010119-t1x9gknd 11888 37 , , , cord-010119-t1x9gknd 11888 38 Patricia Patricia NNP cord-010119-t1x9gknd 11888 39 McKean McKean NNP cord-010119-t1x9gknd 11888 40 1 1 CD cord-010119-t1x9gknd 11888 41 , , , cord-010119-t1x9gknd 11888 42 Cyril Cyril NNP cord-010119-t1x9gknd 11888 43 Jacquot Jacquot NNP cord-010119-t1x9gknd 11888 44 2 2 CD cord-010119-t1x9gknd 11888 45 , , , cord-010119-t1x9gknd 11888 46 Sara Sara NNP cord-010119-t1x9gknd 11888 47 Bakhtary Bakhtary NNP cord-010119-t1x9gknd 11888 48 1 1 CD cord-010119-t1x9gknd 11888 49 and and CC cord-010119-t1x9gknd 11888 50 Ashok Ashok NNP cord-010119-t1x9gknd 11888 51 Nambiar Nambiar NNP cord-010119-t1x9gknd 11888 52 1 1 CD cord-010119-t1x9gknd 11888 53 . . . cord-010119-t1x9gknd 11889 1 1 1 CD cord-010119-t1x9gknd 11889 2 UCSF UCSF NNP cord-010119-t1x9gknd 11889 3 Health Health NNP cord-010119-t1x9gknd 11889 4 , , , cord-010119-t1x9gknd 11889 5 2 2 CD cord-010119-t1x9gknd 11889 6 Children Children NNPS cord-010119-t1x9gknd 11889 7 's 's POS cord-010119-t1x9gknd 11889 8 National National NNP cord-010119-t1x9gknd 11889 9 Medical Medical NNP cord-010119-t1x9gknd 11889 10 Center Center NNP cord-010119-t1x9gknd 11889 11 Background Background NNP cord-010119-t1x9gknd 11889 12 / / SYM cord-010119-t1x9gknd 11889 13 Case Case NNP cord-010119-t1x9gknd 11889 14 Studies Studies NNPS cord-010119-t1x9gknd 11889 15 : : : cord-010119-t1x9gknd 11889 16 Plasma plasma NN cord-010119-t1x9gknd 11889 17 ( ( -LRB- cord-010119-t1x9gknd 11889 18 FFP FFP NNP cord-010119-t1x9gknd 11889 19 , , , cord-010119-t1x9gknd 11889 20 PF24 PF24 NNP cord-010119-t1x9gknd 11889 21 , , , cord-010119-t1x9gknd 11889 22 PF24RT24 PF24RT24 NNP cord-010119-t1x9gknd 11889 23 ) ) -RRB- cord-010119-t1x9gknd 11889 24 stored store VBD cord-010119-t1x9gknd 11889 25 at at IN cord-010119-t1x9gknd 11889 26 1 1 CD cord-010119-t1x9gknd 11889 27 - - HYPH cord-010119-t1x9gknd 11889 28 6C 6c NN cord-010119-t1x9gknd 11889 29 outdates outdate VBZ cord-010119-t1x9gknd 11889 30 24 24 CD cord-010119-t1x9gknd 11889 31 hours hour NNS cord-010119-t1x9gknd 11889 32 after after IN cord-010119-t1x9gknd 11889 33 thawing thaw VBG cord-010119-t1x9gknd 11889 34 . . . cord-010119-t1x9gknd 11890 1 If if IN cord-010119-t1x9gknd 11890 2 collected collect VBN cord-010119-t1x9gknd 11890 3 in in IN cord-010119-t1x9gknd 11890 4 a a DT cord-010119-t1x9gknd 11890 5 functionally functionally RB cord-010119-t1x9gknd 11890 6 closed closed JJ cord-010119-t1x9gknd 11890 7 system system NN cord-010119-t1x9gknd 11890 8 , , , cord-010119-t1x9gknd 11890 9 it -PRON- PRP cord-010119-t1x9gknd 11890 10 may may MD cord-010119-t1x9gknd 11890 11 be be VB cord-010119-t1x9gknd 11890 12 relabeled relabele VBN cord-010119-t1x9gknd 11890 13 as as IN cord-010119-t1x9gknd 11890 14 Thawed Thawed NNP cord-010119-t1x9gknd 11890 15 Plasma Plasma NNP cord-010119-t1x9gknd 11890 16 ( ( -LRB- cord-010119-t1x9gknd 11890 17 TP TP NNP cord-010119-t1x9gknd 11890 18 ) ) -RRB- cord-010119-t1x9gknd 11890 19 , , , cord-010119-t1x9gknd 11890 20 extending extend VBG cord-010119-t1x9gknd 11890 21 expiration expiration NN cord-010119-t1x9gknd 11890 22 to to IN cord-010119-t1x9gknd 11890 23 5 5 CD cord-010119-t1x9gknd 11890 24 days day NNS cord-010119-t1x9gknd 11890 25 from from IN cord-010119-t1x9gknd 11890 26 the the DT cord-010119-t1x9gknd 11890 27 thaw thaw NN cord-010119-t1x9gknd 11890 28 date date NN cord-010119-t1x9gknd 11890 29 . . . cord-010119-t1x9gknd 11891 1 Although although IN cord-010119-t1x9gknd 11891 2 coagulation coagulation NN cord-010119-t1x9gknd 11891 3 factor factor NN cord-010119-t1x9gknd 11891 4 levels level NNS cord-010119-t1x9gknd 11891 5 decrease decrease VBP cord-010119-t1x9gknd 11891 6 over over IN cord-010119-t1x9gknd 11891 7 this this DT cord-010119-t1x9gknd 11891 8 period period NN cord-010119-t1x9gknd 11891 9 , , , cord-010119-t1x9gknd 11891 10 they -PRON- PRP cord-010119-t1x9gknd 11891 11 remain remain VBP cord-010119-t1x9gknd 11891 12 above above IN cord-010119-t1x9gknd 11891 13 hemostatic hemostatic JJ cord-010119-t1x9gknd 11891 14 levels level NNS cord-010119-t1x9gknd 11891 15 . . . cord-010119-t1x9gknd 11892 1 As as IN cord-010119-t1x9gknd 11892 2 TP TP NNP cord-010119-t1x9gknd 11892 3 can can MD cord-010119-t1x9gknd 11892 4 be be VB cord-010119-t1x9gknd 11892 5 safely safely RB cord-010119-t1x9gknd 11892 6 used use VBN cord-010119-t1x9gknd 11892 7 for for IN cord-010119-t1x9gknd 11892 8 the the DT cord-010119-t1x9gknd 11892 9 vast vast JJ cord-010119-t1x9gknd 11892 10 majority majority NN cord-010119-t1x9gknd 11892 11 of of IN cord-010119-t1x9gknd 11892 12 patients patient NNS cord-010119-t1x9gknd 11892 13 requiring require VBG cord-010119-t1x9gknd 11892 14 coagulation coagulation NN cord-010119-t1x9gknd 11892 15 support support NN cord-010119-t1x9gknd 11892 16 , , , cord-010119-t1x9gknd 11892 17 we -PRON- PRP cord-010119-t1x9gknd 11892 18 implemented implement VBD cord-010119-t1x9gknd 11892 19 use use NN cord-010119-t1x9gknd 11892 20 of of IN cord-010119-t1x9gknd 11892 21 TP tp NN cord-010119-t1x9gknd 11892 22 in in IN cord-010119-t1x9gknd 11892 23 our -PRON- PRP$ cord-010119-t1x9gknd 11892 24 multi multi JJ cord-010119-t1x9gknd 11892 25 - - JJ cord-010119-t1x9gknd 11892 26 site site JJ cord-010119-t1x9gknd 11892 27 tertiary tertiary JJ cord-010119-t1x9gknd 11892 28 care care NN cord-010119-t1x9gknd 11892 29 system system NN cord-010119-t1x9gknd 11892 30 , , , cord-010119-t1x9gknd 11892 31 with with IN cord-010119-t1x9gknd 11892 32 the the DT cord-010119-t1x9gknd 11892 33 aim aim NN cord-010119-t1x9gknd 11892 34 of of IN cord-010119-t1x9gknd 11892 35 decreasing decrease VBG cord-010119-t1x9gknd 11892 36 costs cost NNS cord-010119-t1x9gknd 11892 37 and and CC cord-010119-t1x9gknd 11892 38 minimizing minimize VBG cord-010119-t1x9gknd 11892 39 wastage wastage NN cord-010119-t1x9gknd 11892 40 . . . cord-010119-t1x9gknd 11893 1 Study Study NNP cord-010119-t1x9gknd 11893 2 Design Design NNP cord-010119-t1x9gknd 11893 3 / / SYM cord-010119-t1x9gknd 11893 4 Methods method NNS cord-010119-t1x9gknd 11894 1 : : : cord-010119-t1x9gknd 11894 2 The the DT cord-010119-t1x9gknd 11894 3 massive massive JJ cord-010119-t1x9gknd 11894 4 transfusion transfusion NN cord-010119-t1x9gknd 11894 5 protocol protocol NN cord-010119-t1x9gknd 11894 6 at at IN cord-010119-t1x9gknd 11894 7 our -PRON- PRP$ cord-010119-t1x9gknd 11894 8 instiution instiution NN cord-010119-t1x9gknd 11894 9 already already RB cord-010119-t1x9gknd 11894 10 allowed allow VBD cord-010119-t1x9gknd 11894 11 the the DT cord-010119-t1x9gknd 11894 12 use use NN cord-010119-t1x9gknd 11894 13 of of IN cord-010119-t1x9gknd 11894 14 group group NN cord-010119-t1x9gknd 11894 15 AB AB NNP cord-010119-t1x9gknd 11894 16 TP TP NNP cord-010119-t1x9gknd 11894 17 . . . cord-010119-t1x9gknd 11895 1 Following follow VBG cord-010119-t1x9gknd 11895 2 a a DT cord-010119-t1x9gknd 11895 3 review review NN cord-010119-t1x9gknd 11895 4 of of IN cord-010119-t1x9gknd 11895 5 literature literature NN cord-010119-t1x9gknd 11895 6 and and CC cord-010119-t1x9gknd 11895 7 practice practice NN cord-010119-t1x9gknd 11895 8 at at IN cord-010119-t1x9gknd 11895 9 other other JJ cord-010119-t1x9gknd 11895 10 large large JJ cord-010119-t1x9gknd 11895 11 centers center NNS cord-010119-t1x9gknd 11895 12 , , , cord-010119-t1x9gknd 11895 13 the the DT cord-010119-t1x9gknd 11895 14 Transfusion Transfusion NNP cord-010119-t1x9gknd 11895 15 Committee Committee NNP cord-010119-t1x9gknd 11895 16 extended extend VBD cord-010119-t1x9gknd 11895 17 the the DT cord-010119-t1x9gknd 11895 18 approval approval NN cord-010119-t1x9gknd 11895 19 of of IN cord-010119-t1x9gknd 11895 20 TP TP NNP cord-010119-t1x9gknd 11895 21 to to IN cord-010119-t1x9gknd 11895 22 all all DT cord-010119-t1x9gknd 11895 23 patients patient NNS cord-010119-t1x9gknd 11895 24 . . . cord-010119-t1x9gknd 11896 1 Neonates Neonates NNP cord-010119-t1x9gknd 11896 2 ( ( -LRB- cord-010119-t1x9gknd 11896 3 < < NNP cord-010119-t1x9gknd 11896 4 4 4 CD cord-010119-t1x9gknd 11896 5 months month NNS cord-010119-t1x9gknd 11896 6 ) ) -RRB- cord-010119-t1x9gknd 11896 7 , , , cord-010119-t1x9gknd 11896 8 patients patient NNS cord-010119-t1x9gknd 11896 9 undergoing undergo VBG cord-010119-t1x9gknd 11896 10 plasmapheresis plasmapheresis NN cord-010119-t1x9gknd 11896 11 and and CC cord-010119-t1x9gknd 11896 12 those those DT cord-010119-t1x9gknd 11896 13 with with IN cord-010119-t1x9gknd 11896 14 factor factor NN cord-010119-t1x9gknd 11896 15 deficiency deficiency NN cord-010119-t1x9gknd 11896 16 or or CC cord-010119-t1x9gknd 11896 17 other other JJ cord-010119-t1x9gknd 11896 18 disorders disorder NNS cord-010119-t1x9gknd 11896 19 for for IN cord-010119-t1x9gknd 11896 20 which which WDT cord-010119-t1x9gknd 11896 21 We -PRON- PRP cord-010119-t1x9gknd 11896 22 also also RB cord-010119-t1x9gknd 11896 23 noted note VBD cord-010119-t1x9gknd 11896 24 a a DT cord-010119-t1x9gknd 11896 25 significant significant JJ cord-010119-t1x9gknd 11896 26 decrease decrease NN cord-010119-t1x9gknd 11896 27 ( ( -LRB- cord-010119-t1x9gknd 11896 28 not not RB cord-010119-t1x9gknd 11896 29 quantified quantify VBN cord-010119-t1x9gknd 11896 30 ) ) -RRB- cord-010119-t1x9gknd 11896 31 in in IN cord-010119-t1x9gknd 11896 32 technologist technologist NN cord-010119-t1x9gknd 11896 33 time time NN cord-010119-t1x9gknd 11896 34 and and CC cord-010119-t1x9gknd 11896 35 effort effort NN cord-010119-t1x9gknd 11896 36 , , , cord-010119-t1x9gknd 11896 37 as as IN cord-010119-t1x9gknd 11896 38 less less JJR cord-010119-t1x9gknd 11896 39 time time NN cord-010119-t1x9gknd 11896 40 was be VBD cord-010119-t1x9gknd 11896 41 expended expend VBN cord-010119-t1x9gknd 11896 42 on on IN cord-010119-t1x9gknd 11896 43 the the DT cord-010119-t1x9gknd 11896 44 following follow VBG cord-010119-t1x9gknd 11896 45 : : : cord-010119-t1x9gknd 11896 46 thawing thaw VBG cord-010119-t1x9gknd 11896 47 units unit NNS cord-010119-t1x9gknd 11896 48 , , , cord-010119-t1x9gknd 11896 49 printing print VBG cord-010119-t1x9gknd 11896 50 inventory inventory NN cord-010119-t1x9gknd 11896 51 reports report NNS cord-010119-t1x9gknd 11896 52 and and CC cord-010119-t1x9gknd 11896 53 reporting reporting NN cord-010119-t1x9gknd 11896 54 / / SYM cord-010119-t1x9gknd 11896 55 record record NN cord-010119-t1x9gknd 11896 56 - - HYPH cord-010119-t1x9gknd 11896 57 keeping keeping NN cord-010119-t1x9gknd 11896 58 for for IN cord-010119-t1x9gknd 11896 59 discarded discard VBN cord-010119-t1x9gknd 11896 60 units unit NNS cord-010119-t1x9gknd 11896 61 . . . cord-010119-t1x9gknd 11897 1 Conclusion conclusion NN cord-010119-t1x9gknd 11897 2 : : : cord-010119-t1x9gknd 11898 1 In in IN cord-010119-t1x9gknd 11898 2 many many JJ cord-010119-t1x9gknd 11898 3 large large JJ cord-010119-t1x9gknd 11898 4 facilities facility NNS cord-010119-t1x9gknd 11898 5 , , , cord-010119-t1x9gknd 11898 6 providers provider NNS cord-010119-t1x9gknd 11898 7 frequently frequently RB cord-010119-t1x9gknd 11898 8 order order VBP cord-010119-t1x9gknd 11898 9 more more JJR cord-010119-t1x9gknd 11898 10 plasma plasma NN cord-010119-t1x9gknd 11898 11 units unit NNS cord-010119-t1x9gknd 11898 12 than than IN cord-010119-t1x9gknd 11898 13 are be VBP cord-010119-t1x9gknd 11898 14 ultimately ultimately RB cord-010119-t1x9gknd 11898 15 transfused transfuse VBN cord-010119-t1x9gknd 11898 16 , , , cord-010119-t1x9gknd 11898 17 leading lead VBG cord-010119-t1x9gknd 11898 18 to to IN cord-010119-t1x9gknd 11898 19 high high JJ cord-010119-t1x9gknd 11898 20 plasma plasma NN cord-010119-t1x9gknd 11898 21 wastage wastage NN cord-010119-t1x9gknd 11898 22 rates rate NNS cord-010119-t1x9gknd 11898 23 due due JJ cord-010119-t1x9gknd 11898 24 to to IN cord-010119-t1x9gknd 11898 25 limited limited JJ cord-010119-t1x9gknd 11898 26 ( ( -LRB- cord-010119-t1x9gknd 11898 27 24 24 CD cord-010119-t1x9gknd 11898 28 hr hr NN cord-010119-t1x9gknd 11898 29 ) ) -RRB- cord-010119-t1x9gknd 11898 30 shelf shelf NN cord-010119-t1x9gknd 11898 31 - - HYPH cord-010119-t1x9gknd 11898 32 life life NN cord-010119-t1x9gknd 11898 33 . . . cord-010119-t1x9gknd 11899 1 TP TP NNP cord-010119-t1x9gknd 11899 2 has have VBZ cord-010119-t1x9gknd 11899 3 an an DT cord-010119-t1x9gknd 11899 4 extended extended JJ cord-010119-t1x9gknd 11899 5 shelf shelf NN cord-010119-t1x9gknd 11899 6 - - HYPH cord-010119-t1x9gknd 11899 7 life life NN cord-010119-t1x9gknd 11899 8 , , , cord-010119-t1x9gknd 11899 9 and and CC cord-010119-t1x9gknd 11899 10 can can MD cord-010119-t1x9gknd 11899 11 be be VB cord-010119-t1x9gknd 11899 12 used use VBN cord-010119-t1x9gknd 11899 13 interchangeably interchangeably RB cord-010119-t1x9gknd 11899 14 with with IN cord-010119-t1x9gknd 11899 15 FFP FFP NNP cord-010119-t1x9gknd 11899 16 and and CC cord-010119-t1x9gknd 11899 17 PF24 PF24 NNP cord-010119-t1x9gknd 11899 18 for for IN cord-010119-t1x9gknd 11899 19 most most JJS cord-010119-t1x9gknd 11899 20 patients patient NNS cord-010119-t1x9gknd 11899 21 . . . cord-010119-t1x9gknd 11900 1 Implementing implement VBG cord-010119-t1x9gknd 11900 2 TP TP NNP cord-010119-t1x9gknd 11900 3 in in IN cord-010119-t1x9gknd 11900 4 a a DT cord-010119-t1x9gknd 11900 5 multi multi JJ cord-010119-t1x9gknd 11900 6 - - JJ cord-010119-t1x9gknd 11900 7 site site JJ cord-010119-t1x9gknd 11900 8 tertiary tertiary JJ cord-010119-t1x9gknd 11900 9 health health NN cord-010119-t1x9gknd 11900 10 care care NN cord-010119-t1x9gknd 11900 11 system system NN cord-010119-t1x9gknd 11900 12 resulted result VBD cord-010119-t1x9gknd 11900 13 in in IN cord-010119-t1x9gknd 11900 14 sustained sustained JJ cord-010119-t1x9gknd 11900 15 decrease decrease NN cord-010119-t1x9gknd 11900 16 in in IN cord-010119-t1x9gknd 11900 17 plasma plasma NN cord-010119-t1x9gknd 11900 18 wastage wastage NN cord-010119-t1x9gknd 11900 19 , , , cord-010119-t1x9gknd 11900 20 saving save VBG cord-010119-t1x9gknd 11900 21 thousands thousand NNS cord-010119-t1x9gknd 11900 22 of of IN cord-010119-t1x9gknd 11900 23 dollars dollar NNS cord-010119-t1x9gknd 11900 24 and and CC cord-010119-t1x9gknd 11900 25 helping help VBG cord-010119-t1x9gknd 11900 26 conserve conserve VB cord-010119-t1x9gknd 11900 27 a a DT cord-010119-t1x9gknd 11900 28 precious precious JJ cord-010119-t1x9gknd 11900 29 resource resource NN cord-010119-t1x9gknd 11900 30 . . . cord-010119-t1x9gknd 11901 1 The the DT cord-010119-t1x9gknd 11901 2 Merging merging NN cord-010119-t1x9gknd 11901 3 of of IN cord-010119-t1x9gknd 11901 4 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 11901 5 Reference Reference NNP cord-010119-t1x9gknd 11901 6 Lab Lab NNP cord-010119-t1x9gknd 11901 7 's 's POS cord-010119-t1x9gknd 11901 8 ( ( -LRB- cord-010119-t1x9gknd 11901 9 IRL IRL NNP cord-010119-t1x9gknd 11901 10 ) ) -RRB- cord-010119-t1x9gknd 11901 11 Inventories inventory NNS cord-010119-t1x9gknd 11901 12 - - : cord-010119-t1x9gknd 11901 13 Using use VBG cord-010119-t1x9gknd 11901 14 Technology Technology NNP cord-010119-t1x9gknd 11901 15 to to TO cord-010119-t1x9gknd 11901 16 Create create VB cord-010119-t1x9gknd 11901 17 Advanced advanced JJ cord-010119-t1x9gknd 11901 18 Search Search NNP cord-010119-t1x9gknd 11901 19 Functions function NNS cord-010119-t1x9gknd 11902 1 Alexander Alexander NNP cord-010119-t1x9gknd 11902 2 Delk Delk NNP cord-010119-t1x9gknd 11902 3 1 1 CD cord-010119-t1x9gknd 11902 4 and and CC cord-010119-t1x9gknd 11902 5 Richard Richard NNP cord-010119-t1x9gknd 11902 6 Gammon Gammon NNP cord-010119-t1x9gknd 11902 7 * * NFP cord-010119-t1x9gknd 11902 8 2 2 CD cord-010119-t1x9gknd 11902 9 . . . cord-010119-t1x9gknd 11902 10 1 1 CD cord-010119-t1x9gknd 11902 11 OneBlood oneblood CD cord-010119-t1x9gknd 11902 12 , , , cord-010119-t1x9gknd 11903 1 2 2 CD cord-010119-t1x9gknd 11903 2 Oneblood Oneblood NNP cord-010119-t1x9gknd 11903 3 , , , cord-010119-t1x9gknd 11904 1 Inc. Inc. NNP cord-010119-t1x9gknd 11904 2 Background Background NNP cord-010119-t1x9gknd 11904 3 / / SYM cord-010119-t1x9gknd 11904 4 Case Case NNP cord-010119-t1x9gknd 11904 5 Studies Studies NNPS cord-010119-t1x9gknd 11904 6 : : : cord-010119-t1x9gknd 11904 7 Immunohematology Immunohematology NNP cord-010119-t1x9gknd 11904 8 reference reference NN cord-010119-t1x9gknd 11904 9 labs lab NNS cord-010119-t1x9gknd 11904 10 ( ( -LRB- cord-010119-t1x9gknd 11904 11 IRLs IRLs NNP cord-010119-t1x9gknd 11904 12 ) ) -RRB- cord-010119-t1x9gknd 11904 13 must must MD cord-010119-t1x9gknd 11904 14 maintain maintain VB cord-010119-t1x9gknd 11904 15 diverse diverse JJ cord-010119-t1x9gknd 11904 16 inventory inventory NN cord-010119-t1x9gknd 11904 17 of of IN cord-010119-t1x9gknd 11904 18 antisera antisera NN cord-010119-t1x9gknd 11904 19 to to TO cord-010119-t1x9gknd 11904 20 aid aid VB cord-010119-t1x9gknd 11904 21 in in IN cord-010119-t1x9gknd 11904 22 antibody antibody NN cord-010119-t1x9gknd 11904 23 identification identification NN cord-010119-t1x9gknd 11904 24 , , , cord-010119-t1x9gknd 11904 25 antigen antigen NN cord-010119-t1x9gknd 11904 26 type type NN cord-010119-t1x9gknd 11904 27 RBC RBC NNP cord-010119-t1x9gknd 11904 28 units unit NNS cord-010119-t1x9gknd 11904 29 , , , cord-010119-t1x9gknd 11904 30 and and CC cord-010119-t1x9gknd 11904 31 meet meet VB cord-010119-t1x9gknd 11904 32 regulatory regulatory JJ cord-010119-t1x9gknd 11904 33 requirements requirement NNS cord-010119-t1x9gknd 11904 34 . . . cord-010119-t1x9gknd 11905 1 When when WRB cord-010119-t1x9gknd 11905 2 our -PRON- PRP$ cord-010119-t1x9gknd 11905 3 current current JJ cord-010119-t1x9gknd 11905 4 organization organization NN cord-010119-t1x9gknd 11905 5 was be VBD cord-010119-t1x9gknd 11905 6 established establish VBN cord-010119-t1x9gknd 11905 7 , , , cord-010119-t1x9gknd 11905 8 two two CD cord-010119-t1x9gknd 11905 9 IRL IRL NNP cord-010119-t1x9gknd 11905 10 sites site NNS cord-010119-t1x9gknd 11905 11 had have VBD cord-010119-t1x9gknd 11905 12 independent independent JJ cord-010119-t1x9gknd 11905 13 inventory inventory NN cord-010119-t1x9gknd 11905 14 management management NN cord-010119-t1x9gknd 11905 15 systems system NNS cord-010119-t1x9gknd 11905 16 . . . cord-010119-t1x9gknd 11906 1 Although although IN cord-010119-t1x9gknd 11906 2 the the DT cord-010119-t1x9gknd 11906 3 purpose purpose NN cord-010119-t1x9gknd 11906 4 of of IN cord-010119-t1x9gknd 11906 5 maintaining maintain VBG cord-010119-t1x9gknd 11906 6 the the DT cord-010119-t1x9gknd 11906 7 antisera antisera NN cord-010119-t1x9gknd 11906 8 inventory inventory NN cord-010119-t1x9gknd 11906 9 was be VBD cord-010119-t1x9gknd 11906 10 the the DT cord-010119-t1x9gknd 11906 11 same same JJ cord-010119-t1x9gknd 11906 12 , , , cord-010119-t1x9gknd 11906 13 organization organization NN cord-010119-t1x9gknd 11906 14 , , , cord-010119-t1x9gknd 11906 15 storage storage NN cord-010119-t1x9gknd 11906 16 , , , cord-010119-t1x9gknd 11906 17 & & CC cord-010119-t1x9gknd 11906 18 access access NN cord-010119-t1x9gknd 11906 19 to to IN cord-010119-t1x9gknd 11906 20 instructions instruction NNS cord-010119-t1x9gknd 11906 21 for for IN cord-010119-t1x9gknd 11906 22 use use NN cord-010119-t1x9gknd 11906 23 ( ( -LRB- cord-010119-t1x9gknd 11906 24 IFUs ifus NN cord-010119-t1x9gknd 11906 25 ) ) -RRB- cord-010119-t1x9gknd 11906 26 were be VBD cord-010119-t1x9gknd 11906 27 not not RB cord-010119-t1x9gknd 11906 28 . . . cord-010119-t1x9gknd 11907 1 Our -PRON- PRP$ cord-010119-t1x9gknd 11907 2 IRL IRL NNP cord-010119-t1x9gknd 11907 3 developed develop VBD cord-010119-t1x9gknd 11907 4 a a DT cord-010119-t1x9gknd 11907 5 synergistic synergistic JJ cord-010119-t1x9gknd 11907 6 method method NN cord-010119-t1x9gknd 11907 7 to to TO cord-010119-t1x9gknd 11907 8 organize organize VB cord-010119-t1x9gknd 11907 9 and and CC cord-010119-t1x9gknd 11907 10 store store VB cord-010119-t1x9gknd 11907 11 antisera antisera NN cord-010119-t1x9gknd 11907 12 coupled couple VBN cord-010119-t1x9gknd 11907 13 with with IN cord-010119-t1x9gknd 11907 14 in in IN cord-010119-t1x9gknd 11907 15 - - HYPH cord-010119-t1x9gknd 11907 16 house house NN cord-010119-t1x9gknd 11907 17 designed design VBN cord-010119-t1x9gknd 11907 18 custom custom NN cord-010119-t1x9gknd 11907 19 Excel Excel NNP cord-010119-t1x9gknd 11907 20 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11907 21 to to TO cord-010119-t1x9gknd 11907 22 organize organize VB cord-010119-t1x9gknd 11907 23 and and CC cord-010119-t1x9gknd 11907 24 search search VB cord-010119-t1x9gknd 11907 25 antisera antisera NN cord-010119-t1x9gknd 11907 26 and and CC cord-010119-t1x9gknd 11907 27 view view NN cord-010119-t1x9gknd 11907 28 IFUs ifus NN cord-010119-t1x9gknd 11907 29 . . . cord-010119-t1x9gknd 11908 1 Study Study NNP cord-010119-t1x9gknd 11908 2 Design Design NNP cord-010119-t1x9gknd 11908 3 / / SYM cord-010119-t1x9gknd 11908 4 Method method NN cord-010119-t1x9gknd 11908 5 : : : cord-010119-t1x9gknd 11909 1 A a DT cord-010119-t1x9gknd 11909 2 list list NN cord-010119-t1x9gknd 11909 3 of of IN cord-010119-t1x9gknd 11909 4 similarities similarity NNS cord-010119-t1x9gknd 11909 5 and and CC cord-010119-t1x9gknd 11909 6 differences difference NNS cord-010119-t1x9gknd 11909 7 was be VBD cord-010119-t1x9gknd 11909 8 constructed construct VBN cord-010119-t1x9gknd 11909 9 . . . cord-010119-t1x9gknd 11910 1 Best good JJS cord-010119-t1x9gknd 11910 2 practices practice NNS cord-010119-t1x9gknd 11910 3 of of IN cord-010119-t1x9gknd 11910 4 both both DT cord-010119-t1x9gknd 11910 5 methods method NNS cord-010119-t1x9gknd 11910 6 were be VBD cord-010119-t1x9gknd 11910 7 identified identify VBN cord-010119-t1x9gknd 11910 8 . . . cord-010119-t1x9gknd 11911 1 We -PRON- PRP cord-010119-t1x9gknd 11911 2 determined determine VBD cord-010119-t1x9gknd 11911 3 that that IN cord-010119-t1x9gknd 11911 4 our -PRON- PRP$ cord-010119-t1x9gknd 11911 5 antisera antisera NN cord-010119-t1x9gknd 11911 6 could could MD cord-010119-t1x9gknd 11911 7 be be VB cord-010119-t1x9gknd 11911 8 broadly broadly RB cord-010119-t1x9gknd 11911 9 classified classify VBN cord-010119-t1x9gknd 11911 10 / / SYM cord-010119-t1x9gknd 11911 11 organized organize VBN cord-010119-t1x9gknd 11911 12 into into IN cord-010119-t1x9gknd 11911 13 two two CD cord-010119-t1x9gknd 11911 14 main main JJ cord-010119-t1x9gknd 11911 15 categories category NNS cord-010119-t1x9gknd 11911 16 : : : cord-010119-t1x9gknd 11911 17 rare rare JJ cord-010119-t1x9gknd 11911 18 and and CC cord-010119-t1x9gknd 11911 19 bulk bulk JJ cord-010119-t1x9gknd 11911 20 for for IN cord-010119-t1x9gknd 11911 21 screening screening NN cord-010119-t1x9gknd 11911 22 . . . cord-010119-t1x9gknd 11912 1 Sequential sequential JJ cord-010119-t1x9gknd 11912 2 lab lab NN cord-010119-t1x9gknd 11912 3 assigned assign VBN cord-010119-t1x9gknd 11912 4 numbers number NNS cord-010119-t1x9gknd 11912 5 were be VBD cord-010119-t1x9gknd 11912 6 given give VBN cord-010119-t1x9gknd 11912 7 to to IN cord-010119-t1x9gknd 11912 8 antiserum antiserum VB cord-010119-t1x9gknd 11912 9 for for IN cord-010119-t1x9gknd 11912 10 each each DT cord-010119-t1x9gknd 11912 11 category category NN cord-010119-t1x9gknd 11912 12 : : : cord-010119-t1x9gknd 11912 13 S S NNP cord-010119-t1x9gknd 11912 14 ( ( -LRB- cord-010119-t1x9gknd 11912 15 rare rare JJ cord-010119-t1x9gknd 11912 16 Sera Sera NNP cord-010119-t1x9gknd 11912 17 ) ) -RRB- cord-010119-t1x9gknd 11912 18 and and CC cord-010119-t1x9gknd 11912 19 B B NNP cord-010119-t1x9gknd 11912 20 ( ( -LRB- cord-010119-t1x9gknd 11912 21 Bulk Bulk NNP cord-010119-t1x9gknd 11912 22 sera sera NNP cord-010119-t1x9gknd 11912 23 ) ) -RRB- cord-010119-t1x9gknd 11912 24 . . . cord-010119-t1x9gknd 11913 1 A a DT cord-010119-t1x9gknd 11913 2 dynamic dynamic JJ cord-010119-t1x9gknd 11913 3 / / SYM cord-010119-t1x9gknd 11913 4 static static JJ cord-010119-t1x9gknd 11913 5 freezer freezer NN cord-010119-t1x9gknd 11913 6 box box NN cord-010119-t1x9gknd 11913 7 storage storage NN cord-010119-t1x9gknd 11913 8 system system NN cord-010119-t1x9gknd 11913 9 that that WDT cord-010119-t1x9gknd 11913 10 was be VBD cord-010119-t1x9gknd 11913 11 inter inter JJ cord-010119-t1x9gknd 11913 12 - - JJ cord-010119-t1x9gknd 11913 13 box box JJ cord-010119-t1x9gknd 11913 14 static static JJ cord-010119-t1x9gknd 11913 15 and and CC cord-010119-t1x9gknd 11913 16 intra intra JJ cord-010119-t1x9gknd 11913 17 - - JJ cord-010119-t1x9gknd 11913 18 box box JJ cord-010119-t1x9gknd 11913 19 dynamic dynamic NN cord-010119-t1x9gknd 11913 20 was be VBD cord-010119-t1x9gknd 11913 21 determined determine VBN cord-010119-t1x9gknd 11913 22 to to TO cord-010119-t1x9gknd 11913 23 be be VB cord-010119-t1x9gknd 11913 24 best good JJS cord-010119-t1x9gknd 11913 25 option option NN cord-010119-t1x9gknd 11913 26 to to TO cord-010119-t1x9gknd 11913 27 combine combine VB cord-010119-t1x9gknd 11913 28 two two CD cord-010119-t1x9gknd 11913 29 inventories inventory NNS cord-010119-t1x9gknd 11913 30 while while IN cord-010119-t1x9gknd 11913 31 conserving conserve VBG cord-010119-t1x9gknd 11913 32 elements element NNS cord-010119-t1x9gknd 11913 33 of of IN cord-010119-t1x9gknd 11913 34 each each DT cord-010119-t1x9gknd 11913 35 allowing allow VBG cord-010119-t1x9gknd 11913 36 for for IN cord-010119-t1x9gknd 11913 37 library library NN cord-010119-t1x9gknd 11913 38 growth growth NN cord-010119-t1x9gknd 11913 39 . . . cord-010119-t1x9gknd 11914 1 Antisera Antisera NNP cord-010119-t1x9gknd 11914 2 assigned assign VBD cord-010119-t1x9gknd 11914 3 to to IN cord-010119-t1x9gknd 11914 4 a a DT cord-010119-t1x9gknd 11914 5 box box NN cord-010119-t1x9gknd 11914 6 remained remain VBD cord-010119-t1x9gknd 11914 7 in in IN cord-010119-t1x9gknd 11914 8 that that DT cord-010119-t1x9gknd 11914 9 box box NN cord-010119-t1x9gknd 11914 10 , , , cord-010119-t1x9gknd 11914 11 but but CC cord-010119-t1x9gknd 11914 12 may may MD cord-010119-t1x9gknd 11914 13 be be VB cord-010119-t1x9gknd 11914 14 moved move VBN cord-010119-t1x9gknd 11914 15 within within IN cord-010119-t1x9gknd 11914 16 the the DT cord-010119-t1x9gknd 11914 17 box box NN cord-010119-t1x9gknd 11914 18 . . . cord-010119-t1x9gknd 11915 1 The the DT cord-010119-t1x9gknd 11915 2 box box NN cord-010119-t1x9gknd 11915 3 itself -PRON- PRP cord-010119-t1x9gknd 11915 4 may may MD cord-010119-t1x9gknd 11915 5 be be VB cord-010119-t1x9gknd 11915 6 moved move VBN cord-010119-t1x9gknd 11915 7 among among IN cord-010119-t1x9gknd 11915 8 freezers freezer NNS cord-010119-t1x9gknd 11915 9 . . . cord-010119-t1x9gknd 11916 1 To to TO cord-010119-t1x9gknd 11916 2 track track VB cord-010119-t1x9gknd 11916 3 boxes box NNS cord-010119-t1x9gknd 11916 4 , , , cord-010119-t1x9gknd 11916 5 location location NN cord-010119-t1x9gknd 11916 6 and and CC cord-010119-t1x9gknd 11916 7 movement movement NN cord-010119-t1x9gknd 11916 8 within within IN cord-010119-t1x9gknd 11916 9 the the DT cord-010119-t1x9gknd 11916 10 box box NN cord-010119-t1x9gknd 11916 11 , , , cord-010119-t1x9gknd 11916 12 a a DT cord-010119-t1x9gknd 11916 13 custom custom NN cord-010119-t1x9gknd 11916 14 Excel Excel NNP cord-010119-t1x9gknd 11916 15 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11916 16 was be VBD cord-010119-t1x9gknd 11916 17 created create VBN cord-010119-t1x9gknd 11916 18 . . . cord-010119-t1x9gknd 11917 1 Its -PRON- PRP$ cord-010119-t1x9gknd 11917 2 location location NN cord-010119-t1x9gknd 11917 3 tracking tracking NN cord-010119-t1x9gknd 11917 4 feature feature NN cord-010119-t1x9gknd 11917 5 allowed allow VBN cord-010119-t1x9gknd 11917 6 for for IN cord-010119-t1x9gknd 11917 7 two two CD cord-010119-t1x9gknd 11917 8 different different JJ cord-010119-t1x9gknd 11917 9 storage storage NN cord-010119-t1x9gknd 11917 10 methods method NNS cord-010119-t1x9gknd 11917 11 to to TO cord-010119-t1x9gknd 11917 12 function function VB cord-010119-t1x9gknd 11917 13 in in IN cord-010119-t1x9gknd 11917 14 one one CD cord-010119-t1x9gknd 11917 15 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11917 16 . . . cord-010119-t1x9gknd 11918 1 The the DT cord-010119-t1x9gknd 11918 2 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11918 3 had have VBD cord-010119-t1x9gknd 11918 4 a a DT cord-010119-t1x9gknd 11918 5 tab tab NN cord-010119-t1x9gknd 11918 6 for for IN cord-010119-t1x9gknd 11918 7 S S NNP cord-010119-t1x9gknd 11918 8 and and CC cord-010119-t1x9gknd 11918 9 B B NNP cord-010119-t1x9gknd 11918 10 antisera antisera NN cord-010119-t1x9gknd 11918 11 categories category NNS cord-010119-t1x9gknd 11918 12 . . . cord-010119-t1x9gknd 11919 1 ABO ABO NNP cord-010119-t1x9gknd 11919 2 group group NN cord-010119-t1x9gknd 11919 3 , , , cord-010119-t1x9gknd 11919 4 desired desire VBD cord-010119-t1x9gknd 11919 5 and and CC cord-010119-t1x9gknd 11919 6 unwanted unwanted JJ cord-010119-t1x9gknd 11919 7 antibodies antibody NNS cord-010119-t1x9gknd 11919 8 filters filter NNS cord-010119-t1x9gknd 11919 9 allowed allow VBD cord-010119-t1x9gknd 11919 10 quick quick JJ cord-010119-t1x9gknd 11919 11 search search NN cord-010119-t1x9gknd 11919 12 for for IN cord-010119-t1x9gknd 11919 13 appropriate appropriate JJ cord-010119-t1x9gknd 11919 14 antisera antisera NN cord-010119-t1x9gknd 11919 15 . . . cord-010119-t1x9gknd 11920 1 The the DT cord-010119-t1x9gknd 11920 2 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11920 3 also also RB cord-010119-t1x9gknd 11920 4 had have VBD cord-010119-t1x9gknd 11920 5 hyperlinks hyperlink NNS cord-010119-t1x9gknd 11920 6 to to IN cord-010119-t1x9gknd 11920 7 scanned scan VBN cord-010119-t1x9gknd 11920 8 IFUs ifus NN cord-010119-t1x9gknd 11920 9 . . . cord-010119-t1x9gknd 11921 1 Results result NNS cord-010119-t1x9gknd 11922 1 /Finding /finde VBG cord-010119-t1x9gknd 11922 2 : : : cord-010119-t1x9gknd 11923 1 Sequential sequential JJ cord-010119-t1x9gknd 11923 2 lab lab NN cord-010119-t1x9gknd 11923 3 S s NN cord-010119-t1x9gknd 11923 4 and and CC cord-010119-t1x9gknd 11923 5 B B NNP cord-010119-t1x9gknd 11923 6 numbers number NNS cord-010119-t1x9gknd 11923 7 were be VBD cord-010119-t1x9gknd 11923 8 assigned assign VBN cord-010119-t1x9gknd 11923 9 to to IN cord-010119-t1x9gknd 11923 10 new new JJ cord-010119-t1x9gknd 11923 11 additions addition NNS cord-010119-t1x9gknd 11923 12 using use VBG cord-010119-t1x9gknd 11923 13 a a DT cord-010119-t1x9gknd 11923 14 dynamic dynamic JJ cord-010119-t1x9gknd 11923 15 / / SYM cord-010119-t1x9gknd 11923 16 static static JJ cord-010119-t1x9gknd 11923 17 storage storage NN cord-010119-t1x9gknd 11923 18 system system NN cord-010119-t1x9gknd 11923 19 . . . cord-010119-t1x9gknd 11924 1 An an DT cord-010119-t1x9gknd 11924 2 Excel Excel NNP cord-010119-t1x9gknd 11924 3 spreadsheet spreadsheet NN cord-010119-t1x9gknd 11924 4 with with IN cord-010119-t1x9gknd 11924 5 scanned scan VBN cord-010119-t1x9gknd 11924 6 IFUs ifus NN cord-010119-t1x9gknd 11924 7 ( ( -LRB- cord-010119-t1x9gknd 11924 8 hyperlinks hyperlink NNS cord-010119-t1x9gknd 11924 9 ) ) -RRB- cord-010119-t1x9gknd 11924 10 was be VBD cord-010119-t1x9gknd 11924 11 used use VBN cord-010119-t1x9gknd 11924 12 . . . cord-010119-t1x9gknd 11925 1 Pre pre JJ cord-010119-t1x9gknd 11925 2 - - JJ cord-010119-t1x9gknd 11925 3 merger merger JJ cord-010119-t1x9gknd 11925 4 systems system NNS cord-010119-t1x9gknd 11925 5 , , , cord-010119-t1x9gknd 11925 6 it -PRON- PRP cord-010119-t1x9gknd 11925 7 took take VBD cord-010119-t1x9gknd 11925 8 on on RP cord-010119-t1x9gknd 11925 9 average average JJ cord-010119-t1x9gknd 11925 10 5 5 CD cord-010119-t1x9gknd 11925 11 - - SYM cord-010119-t1x9gknd 11925 12 8 8 CD cord-010119-t1x9gknd 11925 13 minutes minute NNS cord-010119-t1x9gknd 11925 14 to to TO cord-010119-t1x9gknd 11925 15 choose choose VB cord-010119-t1x9gknd 11925 16 an an DT cord-010119-t1x9gknd 11925 17 antiserum antiserum NN cord-010119-t1x9gknd 11925 18 and and CC cord-010119-t1x9gknd 11925 19 obtain obtain VB cord-010119-t1x9gknd 11925 20 the the DT cord-010119-t1x9gknd 11925 21 appropriate appropriate JJ cord-010119-t1x9gknd 11925 22 IFU IFU NNP cord-010119-t1x9gknd 11925 23 . . . cord-010119-t1x9gknd 11926 1 Post post JJ cord-010119-t1x9gknd 11926 2 - - JJ cord-010119-t1x9gknd 11926 3 merger merger JJ cord-010119-t1x9gknd 11926 4 system system NN cord-010119-t1x9gknd 11926 5 was be VBD cord-010119-t1x9gknd 11926 6 reduced reduce VBN cord-010119-t1x9gknd 11926 7 to to IN cord-010119-t1x9gknd 11926 8 on on IN cord-010119-t1x9gknd 11926 9 average average JJ cord-010119-t1x9gknd 11926 10 2 2 CD cord-010119-t1x9gknd 11926 11 - - SYM cord-010119-t1x9gknd 11926 12 5 5 CD cord-010119-t1x9gknd 11926 13 minutes minute NNS cord-010119-t1x9gknd 11926 14 . . . cord-010119-t1x9gknd 11927 1 ( ( -LRB- cord-010119-t1x9gknd 11927 2 Table table NN cord-010119-t1x9gknd 11927 3 ) ) -RRB- cord-010119-t1x9gknd 11928 1 Conclusion conclusion NN cord-010119-t1x9gknd 11928 2 : : : cord-010119-t1x9gknd 11929 1 The the DT cord-010119-t1x9gknd 11929 2 merging merging NN cord-010119-t1x9gknd 11929 3 of of IN cord-010119-t1x9gknd 11929 4 two two CD cord-010119-t1x9gknd 11929 5 IRL IRL NNP cord-010119-t1x9gknd 11929 6 's 's POS cord-010119-t1x9gknd 11929 7 antisera antisera NN cord-010119-t1x9gknd 11929 8 inventories inventory NNS cord-010119-t1x9gknd 11929 9 resulted result VBD cord-010119-t1x9gknd 11929 10 in in IN cord-010119-t1x9gknd 11929 11 a a DT cord-010119-t1x9gknd 11929 12 need need NN cord-010119-t1x9gknd 11929 13 for for IN cord-010119-t1x9gknd 11929 14 innovation innovation NN cord-010119-t1x9gknd 11929 15 to to TO cord-010119-t1x9gknd 11929 16 create create VB cord-010119-t1x9gknd 11929 17 an an DT cord-010119-t1x9gknd 11929 18 inventory inventory NN cord-010119-t1x9gknd 11929 19 management management NN cord-010119-t1x9gknd 11929 20 system system NN cord-010119-t1x9gknd 11929 21 with with IN cord-010119-t1x9gknd 11929 22 an an DT cord-010119-t1x9gknd 11929 23 advanced advanced JJ cord-010119-t1x9gknd 11929 24 search search NN cord-010119-t1x9gknd 11929 25 function function NN cord-010119-t1x9gknd 11929 26 and and CC cord-010119-t1x9gknd 11929 27 hyperlinked hyperlinke VBN cord-010119-t1x9gknd 11929 28 IFUs ifus NN cord-010119-t1x9gknd 11929 29 . . . cord-010119-t1x9gknd 11930 1 This this DT cord-010119-t1x9gknd 11930 2 process process NN cord-010119-t1x9gknd 11930 3 saved save VBD cord-010119-t1x9gknd 11930 4 valuable valuable JJ cord-010119-t1x9gknd 11930 5 technologist technologist NN cord-010119-t1x9gknd 11930 6 time time NN cord-010119-t1x9gknd 11930 7 and and CC cord-010119-t1x9gknd 11930 8 organized organize VBD cord-010119-t1x9gknd 11930 9 the the DT cord-010119-t1x9gknd 11930 10 antisera antisera NN cord-010119-t1x9gknd 11930 11 more more RBR cord-010119-t1x9gknd 11930 12 efficiently efficiently RB cord-010119-t1x9gknd 11930 13 . . . cord-010119-t1x9gknd 11931 1 ABSTRACT abstract JJ cord-010119-t1x9gknd 11931 2 continue continue VBP cord-010119-t1x9gknd 11931 3 to to TO cord-010119-t1x9gknd 11931 4 flash flash VB cord-010119-t1x9gknd 11931 5 until until IN cord-010119-t1x9gknd 11931 6 they -PRON- PRP cord-010119-t1x9gknd 11931 7 are be VBP cord-010119-t1x9gknd 11931 8 removed remove VBN cord-010119-t1x9gknd 11931 9 from from IN cord-010119-t1x9gknd 11931 10 shelf shelf NN cord-010119-t1x9gknd 11931 11 and and CC cord-010119-t1x9gknd 11931 12 their -PRON- PRP$ cord-010119-t1x9gknd 11931 13 status status NN cord-010119-t1x9gknd 11931 14 updated update VBN cord-010119-t1x9gknd 11931 15 in in IN cord-010119-t1x9gknd 11931 16 our -PRON- PRP$ cord-010119-t1x9gknd 11931 17 database database NN cord-010119-t1x9gknd 11931 18 . . . cord-010119-t1x9gknd 11931 19 ' ' '' cord-010119-t1x9gknd 11932 1 Units unit NNS cord-010119-t1x9gknd 11932 2 Allocated allocate VBN cord-010119-t1x9gknd 11932 3 ' ' '' cord-010119-t1x9gknd 11932 4 tab tab NN cord-010119-t1x9gknd 11932 5 includes include VBZ cord-010119-t1x9gknd 11932 6 truncated truncated JJ cord-010119-t1x9gknd 11932 7 patient patient JJ cord-010119-t1x9gknd 11932 8 name name NN cord-010119-t1x9gknd 11932 9 ( ( -LRB- cord-010119-t1x9gknd 11932 10 to to TO cord-010119-t1x9gknd 11932 11 protect protect VB cord-010119-t1x9gknd 11932 12 privacy privacy NN cord-010119-t1x9gknd 11932 13 ) ) -RRB- cord-010119-t1x9gknd 11932 14 , , , cord-010119-t1x9gknd 11932 15 unit unit NN cord-010119-t1x9gknd 11932 16 number number NN cord-010119-t1x9gknd 11932 17 , , , cord-010119-t1x9gknd 11932 18 component component NN cord-010119-t1x9gknd 11932 19 type type NN cord-010119-t1x9gknd 11932 20 , , , cord-010119-t1x9gknd 11932 21 allocation allocation NN cord-010119-t1x9gknd 11932 22 and and CC cord-010119-t1x9gknd 11932 23 expiration expiration NN cord-010119-t1x9gknd 11932 24 date date NN cord-010119-t1x9gknd 11932 25 / / SYM cord-010119-t1x9gknd 11932 26 time time NN cord-010119-t1x9gknd 11932 27 , , , cord-010119-t1x9gknd 11932 28 and and CC cord-010119-t1x9gknd 11932 29 time time NN cord-010119-t1x9gknd 11932 30 since since IN cord-010119-t1x9gknd 11932 31 allocation allocation NN cord-010119-t1x9gknd 11932 32 , , , cord-010119-t1x9gknd 11932 33 with with IN cord-010119-t1x9gknd 11932 34 a a DT cord-010119-t1x9gknd 11932 35 flashing flash VBG cord-010119-t1x9gknd 11932 36 alert alert NN cord-010119-t1x9gknd 11932 37 for for IN cord-010119-t1x9gknd 11932 38 units unit NNS cord-010119-t1x9gknd 11932 39 expiring expire VBG cord-010119-t1x9gknd 11932 40 in in IN cord-010119-t1x9gknd 11932 41 < < NNP cord-010119-t1x9gknd 11932 42 4 4 CD cord-010119-t1x9gknd 11932 43 hours hour NNS cord-010119-t1x9gknd 11932 44 . . . cord-010119-t1x9gknd 11933 1 The the DT cord-010119-t1x9gknd 11933 2 XM XM NNP cord-010119-t1x9gknd 11933 3 / / SYM cord-010119-t1x9gknd 11933 4 HLA HLA NNP cord-010119-t1x9gknd 11933 5 Platelets Platelets NNPS cord-010119-t1x9gknd 11933 6 tab tab NN cord-010119-t1x9gknd 11933 7 provides provide VBZ cord-010119-t1x9gknd 11933 8 patient patient JJ cord-010119-t1x9gknd 11933 9 names name NNS cord-010119-t1x9gknd 11933 10 and and CC cord-010119-t1x9gknd 11933 11 status status NN cord-010119-t1x9gknd 11933 12 of of IN cord-010119-t1x9gknd 11933 13 units unit NNS cord-010119-t1x9gknd 11933 14 allocated allocate VBN cord-010119-t1x9gknd 11933 15 . . . cord-010119-t1x9gknd 11934 1 A a DT cord-010119-t1x9gknd 11934 2 ' ' `` cord-010119-t1x9gknd 11934 3 TRXN TRXN NNP cord-010119-t1x9gknd 11934 4 / / SYM cord-010119-t1x9gknd 11934 5 XMPLAT XMPLAT NNP cord-010119-t1x9gknd 11934 6 ' ' POS cord-010119-t1x9gknd 11934 7 tab tab NN cord-010119-t1x9gknd 11934 8 lists list NNS cord-010119-t1x9gknd 11934 9 pending pende VBG cord-010119-t1x9gknd 11934 10 transfusion transfusion NN cord-010119-t1x9gknd 11934 11 reactions reaction NNS cord-010119-t1x9gknd 11934 12 and and CC cord-010119-t1x9gknd 11934 13 platelet platelet NN cord-010119-t1x9gknd 11934 14 cross cross NN cord-010119-t1x9gknd 11934 15 match match NN cord-010119-t1x9gknd 11934 16 reports report NNS cord-010119-t1x9gknd 11934 17 . . . cord-010119-t1x9gknd 11935 1 Dashboard dashboard NN cord-010119-t1x9gknd 11935 2 eliminated eliminate VBD cord-010119-t1x9gknd 11935 3 the the DT cord-010119-t1x9gknd 11935 4 printing printing NN cord-010119-t1x9gknd 11935 5 ( ( -LRB- cord-010119-t1x9gknd 11935 6 several several JJ cord-010119-t1x9gknd 11935 7 times time NNS cord-010119-t1x9gknd 11935 8 / / SYM cord-010119-t1x9gknd 11935 9 shift shift NN cord-010119-t1x9gknd 11935 10 ) ) -RRB- cord-010119-t1x9gknd 11935 11 of of IN cord-010119-t1x9gknd 11935 12 lengthy lengthy JJ cord-010119-t1x9gknd 11935 13 computer computer NN cord-010119-t1x9gknd 11935 14 - - HYPH cord-010119-t1x9gknd 11935 15 generated generate VBN cord-010119-t1x9gknd 11935 16 reports report NNS cord-010119-t1x9gknd 11935 17 , , , cord-010119-t1x9gknd 11935 18 simplified simplify VBN cord-010119-t1x9gknd 11935 19 thawed thawed JJ cord-010119-t1x9gknd 11935 20 plasma plasma NN cord-010119-t1x9gknd 11935 21 inventory inventory NN cord-010119-t1x9gknd 11935 22 management management NN cord-010119-t1x9gknd 11935 23 and and CC cord-010119-t1x9gknd 11935 24 helped help VBD cord-010119-t1x9gknd 11935 25 decrease decrease VB cord-010119-t1x9gknd 11935 26 plasma plasma NN cord-010119-t1x9gknd 11935 27 wastage wastage NN cord-010119-t1x9gknd 11935 28 ( ( -LRB- cord-010119-t1x9gknd 11935 29 from from IN cord-010119-t1x9gknd 11935 30 34 34 CD cord-010119-t1x9gknd 11935 31 % % NN cord-010119-t1x9gknd 11935 32 to to IN cord-010119-t1x9gknd 11935 33 14 14 CD cord-010119-t1x9gknd 11935 34 % % NN cord-010119-t1x9gknd 11935 35 ) ) -RRB- cord-010119-t1x9gknd 11935 36 . . . cord-010119-t1x9gknd 11936 1 Conclusion conclusion NN cord-010119-t1x9gknd 11936 2 : : : cord-010119-t1x9gknd 11936 3 Using use VBG cord-010119-t1x9gknd 11936 4 in in IN cord-010119-t1x9gknd 11936 5 - - HYPH cord-010119-t1x9gknd 11936 6 house house NN cord-010119-t1x9gknd 11936 7 talent talent NN cord-010119-t1x9gknd 11936 8 and and CC cord-010119-t1x9gknd 11936 9 minimal minimal JJ cord-010119-t1x9gknd 11936 10 capital capital NN cord-010119-t1x9gknd 11936 11 expenditure expenditure NN cord-010119-t1x9gknd 11936 12 , , , cord-010119-t1x9gknd 11936 13 we -PRON- PRP cord-010119-t1x9gknd 11936 14 designed design VBD cord-010119-t1x9gknd 11936 15 and and CC cord-010119-t1x9gknd 11936 16 implemented implement VBD cord-010119-t1x9gknd 11936 17 a a DT cord-010119-t1x9gknd 11936 18 dynamic dynamic JJ cord-010119-t1x9gknd 11936 19 web web NN cord-010119-t1x9gknd 11936 20 - - HYPH cord-010119-t1x9gknd 11936 21 based base VBN cord-010119-t1x9gknd 11936 22 dashboard dashboard NN cord-010119-t1x9gknd 11936 23 for for IN cord-010119-t1x9gknd 11936 24 managing manage VBG cord-010119-t1x9gknd 11936 25 blood blood NN cord-010119-t1x9gknd 11936 26 product product NN cord-010119-t1x9gknd 11936 27 inventory inventory NN cord-010119-t1x9gknd 11936 28 across across IN cord-010119-t1x9gknd 11936 29 a a DT cord-010119-t1x9gknd 11936 30 multi multi JJ cord-010119-t1x9gknd 11936 31 - - JJ cord-010119-t1x9gknd 11936 32 site site JJ cord-010119-t1x9gknd 11936 33 transfusion transfusion NN cord-010119-t1x9gknd 11936 34 service service NN cord-010119-t1x9gknd 11936 35 . . . cord-010119-t1x9gknd 11937 1 The the DT cord-010119-t1x9gknd 11937 2 dashboard dashboard NN cord-010119-t1x9gknd 11937 3 is be VBZ cord-010119-t1x9gknd 11937 4 stable stable JJ cord-010119-t1x9gknd 11937 5 , , , cord-010119-t1x9gknd 11937 6 customizable customizable JJ cord-010119-t1x9gknd 11937 7 and and CC cord-010119-t1x9gknd 11937 8 requires require VBZ cord-010119-t1x9gknd 11937 9 little little JJ cord-010119-t1x9gknd 11937 10 maintenance maintenance NN cord-010119-t1x9gknd 11937 11 . . . cord-010119-t1x9gknd 11938 1 Initially initially RB cord-010119-t1x9gknd 11938 2 built build VBN cord-010119-t1x9gknd 11938 3 to to TO cord-010119-t1x9gknd 11938 4 optimize optimize VB cord-010119-t1x9gknd 11938 5 inventory inventory NN cord-010119-t1x9gknd 11938 6 display display NN cord-010119-t1x9gknd 11938 7 for for IN cord-010119-t1x9gknd 11938 8 thawed thawed JJ cord-010119-t1x9gknd 11938 9 plasma plasma NN cord-010119-t1x9gknd 11938 10 implementation implementation NN cord-010119-t1x9gknd 11938 11 , , , cord-010119-t1x9gknd 11938 12 the the DT cord-010119-t1x9gknd 11938 13 dashboard dashboard NN cord-010119-t1x9gknd 11938 14 was be VBD cord-010119-t1x9gknd 11938 15 expanded expand VBN cord-010119-t1x9gknd 11938 16 to to TO cord-010119-t1x9gknd 11938 17 include include VB cord-010119-t1x9gknd 11938 18 all all DT cord-010119-t1x9gknd 11938 19 allogeneic allogeneic IN cord-010119-t1x9gknd 11938 20 blood blood NN cord-010119-t1x9gknd 11938 21 products product NNS cord-010119-t1x9gknd 11938 22 . . . cord-010119-t1x9gknd 11939 1 Over over IN cord-010119-t1x9gknd 11939 2 the the DT cord-010119-t1x9gknd 11939 3 past past JJ cord-010119-t1x9gknd 11939 4 year year NN cord-010119-t1x9gknd 11939 5 , , , cord-010119-t1x9gknd 11939 6 this this DT cord-010119-t1x9gknd 11939 7 tool tool NN cord-010119-t1x9gknd 11939 8 has have VBZ cord-010119-t1x9gknd 11939 9 replaced replace VBN cord-010119-t1x9gknd 11939 10 manual manual JJ cord-010119-t1x9gknd 11939 11 processes process NNS cord-010119-t1x9gknd 11939 12 for for IN cord-010119-t1x9gknd 11939 13 monitoring monitor VBG cord-010119-t1x9gknd 11939 14 and and CC cord-010119-t1x9gknd 11939 15 rotating rotate VBG cord-010119-t1x9gknd 11939 16 inventory inventory NN cord-010119-t1x9gknd 11939 17 and and CC cord-010119-t1x9gknd 11939 18 directly directly RB cord-010119-t1x9gknd 11939 19 helped help VBD cord-010119-t1x9gknd 11939 20 decrease decrease VB cord-010119-t1x9gknd 11939 21 plasma plasma NN cord-010119-t1x9gknd 11939 22 wastage wastage NN cord-010119-t1x9gknd 11939 23 . . . cord-010119-t1x9gknd 11940 1 Use use NN cord-010119-t1x9gknd 11940 2 of of IN cord-010119-t1x9gknd 11940 3 Deglycerolized Deglycerolized NNP cord-010119-t1x9gknd 11940 4 Red Red NNP cord-010119-t1x9gknd 11940 5 Blood Blood NNP cord-010119-t1x9gknd 11940 6 Cells Cells NNPS cord-010119-t1x9gknd 11940 7 for for IN cord-010119-t1x9gknd 11940 8 Hospital Hospital NNP cord-010119-t1x9gknd 11940 9 Transfusion Transfusion NNP cord-010119-t1x9gknd 11940 10 Service Service NNP cord-010119-t1x9gknd 11940 11 Inventory Inventory NNP cord-010119-t1x9gknd 11940 12 Management Management NNP cord-010119-t1x9gknd 11940 13 Ronnie Ronnie NNP cord-010119-t1x9gknd 11940 14 L. L. NNP cord-010119-t1x9gknd 11940 15 Hill Hill NNP cord-010119-t1x9gknd 11941 1 * * NFP cord-010119-t1x9gknd 11941 2 , , , cord-010119-t1x9gknd 11941 3 Jason Jason NNP cord-010119-t1x9gknd 11941 4 Corley Corley NNP cord-010119-t1x9gknd 11941 5 and and CC cord-010119-t1x9gknd 11941 6 Lizabeth Lizabeth NNP cord-010119-t1x9gknd 11941 7 Ostiguin Ostiguin NNP cord-010119-t1x9gknd 11941 8 . . . cord-010119-t1x9gknd 11942 1 US US NNP cord-010119-t1x9gknd 11942 2 Army Army NNP cord-010119-t1x9gknd 11942 3 Background Background NNP cord-010119-t1x9gknd 11942 4 / / SYM cord-010119-t1x9gknd 11942 5 Case Case NNP cord-010119-t1x9gknd 11942 6 Studies Studies NNPS cord-010119-t1x9gknd 11943 1 : : : cord-010119-t1x9gknd 11943 2 Regional regional JJ cord-010119-t1x9gknd 11943 3 blood blood NN cord-010119-t1x9gknd 11943 4 shortages shortage NNS cord-010119-t1x9gknd 11943 5 have have VBP cord-010119-t1x9gknd 11943 6 been be VBN cord-010119-t1x9gknd 11943 7 documented document VBN cord-010119-t1x9gknd 11943 8 across across IN cord-010119-t1x9gknd 11943 9 the the DT cord-010119-t1x9gknd 11943 10 United United NNP cord-010119-t1x9gknd 11943 11 States States NNP cord-010119-t1x9gknd 11943 12 during during IN cord-010119-t1x9gknd 11943 13 the the DT cord-010119-t1x9gknd 11943 14 winter winter NN cord-010119-t1x9gknd 11943 15 holiday holiday NN cord-010119-t1x9gknd 11943 16 timeframe timeframe NNP cord-010119-t1x9gknd 11943 17 . . . cord-010119-t1x9gknd 11944 1 Deglycerolized Deglycerolized NNP cord-010119-t1x9gknd 11944 2 Red Red NNP cord-010119-t1x9gknd 11944 3 Blood Blood NNP cord-010119-t1x9gknd 11944 4 Cells cell NNS cord-010119-t1x9gknd 11944 5 ( ( -LRB- cord-010119-t1x9gknd 11944 6 DRBCs drbc NNS cord-010119-t1x9gknd 11944 7 ) ) -RRB- cord-010119-t1x9gknd 11944 8 have have VBP cord-010119-t1x9gknd 11944 9 been be VBN cord-010119-t1x9gknd 11944 10 shown show VBN cord-010119-t1x9gknd 11944 11 to to TO cord-010119-t1x9gknd 11944 12 be be VB cord-010119-t1x9gknd 11944 13 an an DT cord-010119-t1x9gknd 11944 14 effective effective JJ cord-010119-t1x9gknd 11944 15 alternative alternative NN cord-010119-t1x9gknd 11944 16 though though IN cord-010119-t1x9gknd 11944 17 more more RBR cord-010119-t1x9gknd 11944 18 expensive expensive JJ cord-010119-t1x9gknd 11944 19 to to TO cord-010119-t1x9gknd 11944 20 manufacture manufacture VB cord-010119-t1x9gknd 11944 21 . . . cord-010119-t1x9gknd 11945 1 This this DT cord-010119-t1x9gknd 11945 2 study study NN cord-010119-t1x9gknd 11945 3 looks look VBZ cord-010119-t1x9gknd 11945 4 into into IN cord-010119-t1x9gknd 11945 5 the the DT cord-010119-t1x9gknd 11945 6 fiscal fiscal JJ cord-010119-t1x9gknd 11945 7 and and CC cord-010119-t1x9gknd 11945 8 inventory inventory NN cord-010119-t1x9gknd 11945 9 efficacy efficacy NN cord-010119-t1x9gknd 11945 10 of of IN cord-010119-t1x9gknd 11945 11 using use VBG cord-010119-t1x9gknd 11945 12 DRBCs drbc NNS cord-010119-t1x9gknd 11945 13 to to TO cord-010119-t1x9gknd 11945 14 meet meet VB cord-010119-t1x9gknd 11945 15 the the DT cord-010119-t1x9gknd 11945 16 needs need NNS cord-010119-t1x9gknd 11945 17 of of IN cord-010119-t1x9gknd 11945 18 transfusion transfusion NN cord-010119-t1x9gknd 11945 19 services service NNS cord-010119-t1x9gknd 11945 20 during during IN cord-010119-t1x9gknd 11945 21 times time NNS cord-010119-t1x9gknd 11945 22 of of IN cord-010119-t1x9gknd 11945 23 blood blood NN cord-010119-t1x9gknd 11945 24 shortage shortage NN cord-010119-t1x9gknd 11945 25 . . . cord-010119-t1x9gknd 11946 1 Study Study NNP cord-010119-t1x9gknd 11946 2 Design Design NNP cord-010119-t1x9gknd 11946 3 / / SYM cord-010119-t1x9gknd 11946 4 Method method NN cord-010119-t1x9gknd 11946 5 : : : cord-010119-t1x9gknd 11947 1 On on IN cord-010119-t1x9gknd 11947 2 three three CD cord-010119-t1x9gknd 11947 3 separate separate JJ cord-010119-t1x9gknd 11947 4 occasions occasion NNS cord-010119-t1x9gknd 11947 5 , , , cord-010119-t1x9gknd 11947 6 a a DT cord-010119-t1x9gknd 11947 7 medium medium JJ cord-010119-t1x9gknd 11947 8 sized sized JJ cord-010119-t1x9gknd 11947 9 DoD DoD NNP cord-010119-t1x9gknd 11947 10 donor donor NNP cord-010119-t1x9gknd 11947 11 center center NN cord-010119-t1x9gknd 11947 12 used use VBD cord-010119-t1x9gknd 11947 13 its -PRON- PRP$ cord-010119-t1x9gknd 11947 14 frozen frozen JJ cord-010119-t1x9gknd 11947 15 blood blood NN cord-010119-t1x9gknd 11947 16 inventory inventory NN cord-010119-t1x9gknd 11947 17 to to TO cord-010119-t1x9gknd 11947 18 produce produce VB cord-010119-t1x9gknd 11947 19 type type NN cord-010119-t1x9gknd 11947 20 O o NN cord-010119-t1x9gknd 11947 21 DRBCs drbc NNS cord-010119-t1x9gknd 11947 22 to to TO cord-010119-t1x9gknd 11947 23 meet meet VB cord-010119-t1x9gknd 11947 24 the the DT cord-010119-t1x9gknd 11947 25 needs need NNS cord-010119-t1x9gknd 11947 26 of of IN cord-010119-t1x9gknd 11947 27 two two CD cord-010119-t1x9gknd 11947 28 regional regional JJ cord-010119-t1x9gknd 11947 29 transfusion transfusion NN cord-010119-t1x9gknd 11947 30 services service NNS cord-010119-t1x9gknd 11947 31 . . . cord-010119-t1x9gknd 11948 1 All all DT cord-010119-t1x9gknd 11948 2 frozen frozen JJ cord-010119-t1x9gknd 11948 3 red red JJ cord-010119-t1x9gknd 11948 4 cells cell NNS cord-010119-t1x9gknd 11948 5 were be VBD cord-010119-t1x9gknd 11948 6 manufactured manufacture VBN cord-010119-t1x9gknd 11948 7 by by IN cord-010119-t1x9gknd 11948 8 an an DT cord-010119-t1x9gknd 11948 9 offsite offsite JJ cord-010119-t1x9gknd 11948 10 facility facility NN cord-010119-t1x9gknd 11948 11 with with IN cord-010119-t1x9gknd 11948 12 the the DT cord-010119-t1x9gknd 11948 13 Haemonetics Haemonetics NNPS cord-010119-t1x9gknd 11948 14 ACP-215 acp-215 DT cord-010119-t1x9gknd 11948 15 using use VBG cord-010119-t1x9gknd 11948 16 the the DT cord-010119-t1x9gknd 11948 17 low low JJ cord-010119-t1x9gknd 11948 18 glycerol glycerol NN cord-010119-t1x9gknd 11948 19 ( ( -LRB- cord-010119-t1x9gknd 11948 20 40 40 CD cord-010119-t1x9gknd 11948 21 % % NN cord-010119-t1x9gknd 11948 22 ) ) -RRB- cord-010119-t1x9gknd 11948 23 freezing freezing NN cord-010119-t1x9gknd 11948 24 method method NN cord-010119-t1x9gknd 11948 25 and and CC cord-010119-t1x9gknd 11948 26 frozen freeze VBN cord-010119-t1x9gknd 11948 27 at at IN cord-010119-t1x9gknd 11948 28 -658C -658C . cord-010119-t1x9gknd 11949 1 within within IN cord-010119-t1x9gknd 11949 2 six six CD cord-010119-t1x9gknd 11949 3 days day NNS cord-010119-t1x9gknd 11949 4 of of IN cord-010119-t1x9gknd 11949 5 collection collection NN cord-010119-t1x9gknd 11949 6 . . . cord-010119-t1x9gknd 11950 1 Thawing thaw VBG cord-010119-t1x9gknd 11950 2 occurred occur VBD cord-010119-t1x9gknd 11950 3 in in IN cord-010119-t1x9gknd 11950 4 a a DT cord-010119-t1x9gknd 11950 5 328C 328c CD cord-010119-t1x9gknd 11950 6 water water NN cord-010119-t1x9gknd 11950 7 bath bath NN cord-010119-t1x9gknd 11950 8 in in IN cord-010119-t1x9gknd 11950 9 the the DT cord-010119-t1x9gknd 11950 10 following following JJ cord-010119-t1x9gknd 11950 11 order order NN cord-010119-t1x9gknd 11950 12 : : : cord-010119-t1x9gknd 11950 13 7 7 CD cord-010119-t1x9gknd 11950 14 O o NN cord-010119-t1x9gknd 11950 15 Positive positive JJ cord-010119-t1x9gknd 11950 16 and and CC cord-010119-t1x9gknd 11950 17 1 1 CD cord-010119-t1x9gknd 11950 18 O o NN cord-010119-t1x9gknd 11950 19 Negative negative JJ cord-010119-t1x9gknd 11950 20 on on IN cord-010119-t1x9gknd 11950 21 3 3 CD cord-010119-t1x9gknd 11950 22 January January NNP cord-010119-t1x9gknd 11950 23 2017 2017 CD cord-010119-t1x9gknd 11950 24 ; ; : cord-010119-t1x9gknd 11950 25 7 7 CD cord-010119-t1x9gknd 11950 26 O o NN cord-010119-t1x9gknd 11950 27 Positive positive JJ cord-010119-t1x9gknd 11950 28 and and CC cord-010119-t1x9gknd 11950 29 1 1 CD cord-010119-t1x9gknd 11950 30 O o NN cord-010119-t1x9gknd 11950 31 Negative negative JJ cord-010119-t1x9gknd 11950 32 on on IN cord-010119-t1x9gknd 11950 33 7 7 CD cord-010119-t1x9gknd 11950 34 February February NNP cord-010119-t1x9gknd 11950 35 2017 2017 CD cord-010119-t1x9gknd 11950 36 ; ; : cord-010119-t1x9gknd 11950 37 and and CC cord-010119-t1x9gknd 11950 38 8 8 CD cord-010119-t1x9gknd 11950 39 O o NN cord-010119-t1x9gknd 11950 40 Negative negative JJ cord-010119-t1x9gknd 11950 41 on on IN cord-010119-t1x9gknd 11950 42 22 22 CD cord-010119-t1x9gknd 11950 43 February February NNP cord-010119-t1x9gknd 11950 44 2017 2017 CD cord-010119-t1x9gknd 11950 45 . . . cord-010119-t1x9gknd 11951 1 Deglycerolization deglycerolization NN cord-010119-t1x9gknd 11951 2 occurred occur VBD cord-010119-t1x9gknd 11951 3 on on IN cord-010119-t1x9gknd 11951 4 site site NN cord-010119-t1x9gknd 11951 5 using use VBG cord-010119-t1x9gknd 11951 6 the the DT cord-010119-t1x9gknd 11951 7 ACP-215 acp-215 NN cord-010119-t1x9gknd 11951 8 with with IN cord-010119-t1x9gknd 11951 9 all all DT cord-010119-t1x9gknd 11951 10 units unit NNS cord-010119-t1x9gknd 11951 11 passing pass VBG cord-010119-t1x9gknd 11951 12 internal internal JJ cord-010119-t1x9gknd 11951 13 QC QC NNP cord-010119-t1x9gknd 11951 14 requirements requirement NNS cord-010119-t1x9gknd 11951 15 . . . cord-010119-t1x9gknd 11952 1 DRBCs drbc NNS cord-010119-t1x9gknd 11952 2 were be VBD cord-010119-t1x9gknd 11952 3 shipped ship VBN cord-010119-t1x9gknd 11952 4 the the DT cord-010119-t1x9gknd 11952 5 same same JJ cord-010119-t1x9gknd 11952 6 day day NN cord-010119-t1x9gknd 11952 7 to to IN cord-010119-t1x9gknd 11952 8 a a DT cord-010119-t1x9gknd 11952 9 hospital hospital NN cord-010119-t1x9gknd 11952 10 transfusion transfusion NN cord-010119-t1x9gknd 11952 11 service service NN cord-010119-t1x9gknd 11952 12 , , , cord-010119-t1x9gknd 11952 13 allowing allow VBG cord-010119-t1x9gknd 11952 14 for for IN cord-010119-t1x9gknd 11952 15 13 13 CD cord-010119-t1x9gknd 11952 16 days day NNS cord-010119-t1x9gknd 11952 17 of of IN cord-010119-t1x9gknd 11952 18 shelf shelf NN cord-010119-t1x9gknd 11952 19 life life NN cord-010119-t1x9gknd 11952 20 prior prior RB cord-010119-t1x9gknd 11952 21 to to IN cord-010119-t1x9gknd 11952 22 expiration expiration NN cord-010119-t1x9gknd 11952 23 . . . cord-010119-t1x9gknd 11953 1 Results result NNS cord-010119-t1x9gknd 11954 1 /Finding /finde VBG cord-010119-t1x9gknd 11954 2 : : : cord-010119-t1x9gknd 11954 3 During during IN cord-010119-t1x9gknd 11954 4 the the DT cord-010119-t1x9gknd 11954 5 three three CD cord-010119-t1x9gknd 11954 6 events event NNS cord-010119-t1x9gknd 11954 7 , , , cord-010119-t1x9gknd 11954 8 all all DT cord-010119-t1x9gknd 11954 9 supported support VBN cord-010119-t1x9gknd 11954 10 transfusion transfusion NN cord-010119-t1x9gknd 11954 11 services service NNS cord-010119-t1x9gknd 11954 12 and and CC cord-010119-t1x9gknd 11954 13 the the DT cord-010119-t1x9gknd 11954 14 blood blood NN cord-010119-t1x9gknd 11954 15 center center NN cord-010119-t1x9gknd 11954 16 were be VBD cord-010119-t1x9gknd 11954 17 below below IN cord-010119-t1x9gknd 11954 18 minimum minimum JJ cord-010119-t1x9gknd 11954 19 inventory inventory NN cord-010119-t1x9gknd 11954 20 requirements requirement NNS cord-010119-t1x9gknd 11954 21 for for IN cord-010119-t1x9gknd 11954 22 standard standard JJ cord-010119-t1x9gknd 11954 23 type type NN cord-010119-t1x9gknd 11954 24 O o NN cord-010119-t1x9gknd 11954 25 red red JJ cord-010119-t1x9gknd 11954 26 blood blood NN cord-010119-t1x9gknd 11954 27 cells cell NNS cord-010119-t1x9gknd 11954 28 ( ( -LRB- cord-010119-t1x9gknd 11954 29 RBCs rbc NNS cord-010119-t1x9gknd 11954 30 ) ) -RRB- cord-010119-t1x9gknd 11954 31 . . . cord-010119-t1x9gknd 11955 1 O o UH cord-010119-t1x9gknd 11956 1 Positive positive JJ cord-010119-t1x9gknd 11956 2 RBCs rbc NNS cord-010119-t1x9gknd 11956 3 were be VBD cord-010119-t1x9gknd 11956 4 only only RB cord-010119-t1x9gknd 11956 5 available available JJ cord-010119-t1x9gknd 11956 6 through through IN cord-010119-t1x9gknd 11956 7 NBE NBE NNP cord-010119-t1x9gknd 11956 8 at at IN cord-010119-t1x9gknd 11956 9 $ $ $ cord-010119-t1x9gknd 11956 10 240 240 CD cord-010119-t1x9gknd 11956 11 - - HYPH cord-010119-t1x9gknd 11956 12 280 280 CD cord-010119-t1x9gknd 11956 13 and and CC cord-010119-t1x9gknd 11956 14 had have VBD cord-010119-t1x9gknd 11956 15 the the DT cord-010119-t1x9gknd 11956 16 limitation limitation NN cord-010119-t1x9gknd 11956 17 of of IN cord-010119-t1x9gknd 11956 18 arrival arrival NN cord-010119-t1x9gknd 11956 19 on on IN cord-010119-t1x9gknd 11956 20 the the DT cord-010119-t1x9gknd 11956 21 next next JJ cord-010119-t1x9gknd 11956 22 business business NN cord-010119-t1x9gknd 11956 23 day day NN cord-010119-t1x9gknd 11956 24 . . . cord-010119-t1x9gknd 11957 1 Collection collection NN cord-010119-t1x9gknd 11957 2 and and CC cord-010119-t1x9gknd 11957 3 processing processing NN cord-010119-t1x9gknd 11957 4 time time NN cord-010119-t1x9gknd 11957 5 of of IN cord-010119-t1x9gknd 11957 6 liquid liquid JJ cord-010119-t1x9gknd 11957 7 RBCs rbc NNS cord-010119-t1x9gknd 11957 8 takes take VBZ cord-010119-t1x9gknd 11957 9 approximately approximately RB cord-010119-t1x9gknd 11957 10 two two CD cord-010119-t1x9gknd 11957 11 days day NNS cord-010119-t1x9gknd 11957 12 including include VBG cord-010119-t1x9gknd 11957 13 : : : cord-010119-t1x9gknd 11957 14 donor donor NN cord-010119-t1x9gknd 11957 15 screening screening NN cord-010119-t1x9gknd 11957 16 , , , cord-010119-t1x9gknd 11957 17 phlebotomy phlebotomy NN cord-010119-t1x9gknd 11957 18 , , , cord-010119-t1x9gknd 11957 19 component component NN cord-010119-t1x9gknd 11957 20 processing processing NN cord-010119-t1x9gknd 11957 21 , , , cord-010119-t1x9gknd 11957 22 testing testing NN cord-010119-t1x9gknd 11957 23 , , , cord-010119-t1x9gknd 11957 24 and and CC cord-010119-t1x9gknd 11957 25 labeling labeling NN cord-010119-t1x9gknd 11957 26 . . . cord-010119-t1x9gknd 11958 1 DRBCs drbc NNS cord-010119-t1x9gknd 11958 2 cost cost VBD cord-010119-t1x9gknd 11958 3 the the DT cord-010119-t1x9gknd 11958 4 DoD DoD NNP cord-010119-t1x9gknd 11958 5 on on IN cord-010119-t1x9gknd 11958 6 average average JJ cord-010119-t1x9gknd 11958 7 $ $ $ cord-010119-t1x9gknd 11958 8 400 400 CD cord-010119-t1x9gknd 11958 9 per per IN cord-010119-t1x9gknd 11958 10 unit unit NN cord-010119-t1x9gknd 11958 11 to to TO cord-010119-t1x9gknd 11958 12 produce produce VB cord-010119-t1x9gknd 11958 13 and and CC cord-010119-t1x9gknd 11958 14 distribute distribute VB cord-010119-t1x9gknd 11958 15 . . . cord-010119-t1x9gknd 11959 1 DRBCs drbc NNS cord-010119-t1x9gknd 11959 2 have have VBP cord-010119-t1x9gknd 11959 3 a a DT cord-010119-t1x9gknd 11959 4 shorter short JJR cord-010119-t1x9gknd 11959 5 shelf shelf NN cord-010119-t1x9gknd 11959 6 life life NN cord-010119-t1x9gknd 11959 7 , , , cord-010119-t1x9gknd 11959 8 14 14 CD cord-010119-t1x9gknd 11959 9 days day NNS cord-010119-t1x9gknd 11959 10 versus versus IN cord-010119-t1x9gknd 11959 11 the the DT cord-010119-t1x9gknd 11959 12 211 211 CD cord-010119-t1x9gknd 11959 13 days day NNS cord-010119-t1x9gknd 11959 14 for for IN cord-010119-t1x9gknd 11959 15 other other JJ cord-010119-t1x9gknd 11959 16 RBCs rbc NNS cord-010119-t1x9gknd 11959 17 , , , cord-010119-t1x9gknd 11959 18 but but CC cord-010119-t1x9gknd 11959 19 are be VBP cord-010119-t1x9gknd 11959 20 washed wash VBN cord-010119-t1x9gknd 11959 21 during during IN cord-010119-t1x9gknd 11959 22 deglycerolization deglycerolization NN cord-010119-t1x9gknd 11959 23 and and CC cord-010119-t1x9gknd 11959 24 thus thus RB cord-010119-t1x9gknd 11959 25 produce produce VB cord-010119-t1x9gknd 11959 26 fewer few JJR cord-010119-t1x9gknd 11959 27 transfusion transfusion NN cord-010119-t1x9gknd 11959 28 reactions reaction NNS cord-010119-t1x9gknd 11959 29 . . . cord-010119-t1x9gknd 11960 1 One one CD cord-010119-t1x9gknd 11960 2 tech tech NN cord-010119-t1x9gknd 11960 3 can can MD cord-010119-t1x9gknd 11960 4 operate operate VB cord-010119-t1x9gknd 11960 5 up up IN cord-010119-t1x9gknd 11960 6 to to TO cord-010119-t1x9gknd 11960 7 four four CD cord-010119-t1x9gknd 11960 8 ACP-215 acp-215 NN cord-010119-t1x9gknd 11960 9 's 's POS cord-010119-t1x9gknd 11960 10 and and CC cord-010119-t1x9gknd 11960 11 deglycerolize deglycerolize NNP cord-010119-t1x9gknd 11960 12 four four CD cord-010119-t1x9gknd 11960 13 units unit NNS cord-010119-t1x9gknd 11960 14 at at IN cord-010119-t1x9gknd 11960 15 a a DT cord-010119-t1x9gknd 11960 16 time time NN cord-010119-t1x9gknd 11960 17 . . . cord-010119-t1x9gknd 11961 1 In in IN cord-010119-t1x9gknd 11961 2 January January NNP cord-010119-t1x9gknd 11961 3 and and CC cord-010119-t1x9gknd 11961 4 February February NNP cord-010119-t1x9gknd 11961 5 2017 2017 CD cord-010119-t1x9gknd 11961 6 , , , cord-010119-t1x9gknd 11961 7 it -PRON- PRP cord-010119-t1x9gknd 11961 8 took take VBD cord-010119-t1x9gknd 11961 9 one one CD cord-010119-t1x9gknd 11961 10 tech tech NN cord-010119-t1x9gknd 11961 11 four four CD cord-010119-t1x9gknd 11961 12 hours hour NNS cord-010119-t1x9gknd 11961 13 per per IN cord-010119-t1x9gknd 11961 14 iteration iteration NN cord-010119-t1x9gknd 11961 15 of of IN cord-010119-t1x9gknd 11961 16 eight eight CD cord-010119-t1x9gknd 11961 17 units unit NNS cord-010119-t1x9gknd 11961 18 to to TO cord-010119-t1x9gknd 11961 19 include include VB cord-010119-t1x9gknd 11961 20 thawing thawing NN cord-010119-t1x9gknd 11961 21 , , , cord-010119-t1x9gknd 11961 22 labeling labeling NN cord-010119-t1x9gknd 11961 23 , , , cord-010119-t1x9gknd 11961 24 and and CC cord-010119-t1x9gknd 11961 25 packing pack VBG cord-010119-t1x9gknd 11961 26 for for IN cord-010119-t1x9gknd 11961 27 shipment shipment NN cord-010119-t1x9gknd 11961 28 . . . cord-010119-t1x9gknd 11962 1 Conclusion conclusion NN cord-010119-t1x9gknd 11962 2 : : : cord-010119-t1x9gknd 11962 3 While while IN cord-010119-t1x9gknd 11962 4 not not RB cord-010119-t1x9gknd 11962 5 as as RB cord-010119-t1x9gknd 11962 6 readily readily RB cord-010119-t1x9gknd 11962 7 available available JJ cord-010119-t1x9gknd 11962 8 as as IN cord-010119-t1x9gknd 11962 9 traditional traditional JJ cord-010119-t1x9gknd 11962 10 RBCs rbc NNS cord-010119-t1x9gknd 11962 11 , , , cord-010119-t1x9gknd 11962 12 DRBCs drbc NNS cord-010119-t1x9gknd 11962 13 can can MD cord-010119-t1x9gknd 11962 14 be be VB cord-010119-t1x9gknd 11962 15 an an DT cord-010119-t1x9gknd 11962 16 effective effective JJ cord-010119-t1x9gknd 11962 17 product product NN cord-010119-t1x9gknd 11962 18 to to TO cord-010119-t1x9gknd 11962 19 bridge bridge VB cord-010119-t1x9gknd 11962 20 the the DT cord-010119-t1x9gknd 11962 21 inventory inventory NN cord-010119-t1x9gknd 11962 22 gap gap NN cord-010119-t1x9gknd 11962 23 when when WRB cord-010119-t1x9gknd 11962 24 small small JJ cord-010119-t1x9gknd 11962 25 numbers number NNS cord-010119-t1x9gknd 11962 26 of of IN cord-010119-t1x9gknd 11962 27 units unit NNS cord-010119-t1x9gknd 11962 28 are be VBP cord-010119-t1x9gknd 11962 29 needed need VBN cord-010119-t1x9gknd 11962 30 due due IN cord-010119-t1x9gknd 11962 31 to to IN cord-010119-t1x9gknd 11962 32 reduced reduce VBN cord-010119-t1x9gknd 11962 33 inventory inventory NN cord-010119-t1x9gknd 11962 34 . . . cord-010119-t1x9gknd 11963 1 Collection collection NN cord-010119-t1x9gknd 11963 2 and and CC cord-010119-t1x9gknd 11963 3 processing processing NN cord-010119-t1x9gknd 11963 4 of of IN cord-010119-t1x9gknd 11963 5 whole whole JJ cord-010119-t1x9gknd 11963 6 blood blood NN cord-010119-t1x9gknd 11963 7 into into IN cord-010119-t1x9gknd 11963 8 components component NNS cord-010119-t1x9gknd 11963 9 takes take VBZ cord-010119-t1x9gknd 11963 10 approximately approximately RB cord-010119-t1x9gknd 11963 11 two two CD cord-010119-t1x9gknd 11963 12 days day NNS cord-010119-t1x9gknd 11963 13 , , , cord-010119-t1x9gknd 11963 14 but but CC cord-010119-t1x9gknd 11963 15 can can MD cord-010119-t1x9gknd 11963 16 produce produce VB cord-010119-t1x9gknd 11963 17 greater great JJR cord-010119-t1x9gknd 11963 18 numbers number NNS cord-010119-t1x9gknd 11963 19 of of IN cord-010119-t1x9gknd 11963 20 units unit NNS cord-010119-t1x9gknd 11963 21 in in IN cord-010119-t1x9gknd 11963 22 that that DT cord-010119-t1x9gknd 11963 23 timeframe timeframe NN cord-010119-t1x9gknd 11963 24 . . . cord-010119-t1x9gknd 11964 1 Based base VBN cord-010119-t1x9gknd 11964 2 on on IN cord-010119-t1x9gknd 11964 3 this this DT cord-010119-t1x9gknd 11964 4 , , , cord-010119-t1x9gknd 11964 5 DRBCs drbc NNS cord-010119-t1x9gknd 11964 6 can can MD cord-010119-t1x9gknd 11964 7 be be VB cord-010119-t1x9gknd 11964 8 ready ready JJ cord-010119-t1x9gknd 11964 9 faster fast RBR cord-010119-t1x9gknd 11964 10 than than IN cord-010119-t1x9gknd 11964 11 freshly freshly RB cord-010119-t1x9gknd 11964 12 collected collect VBN cord-010119-t1x9gknd 11964 13 units unit NNS cord-010119-t1x9gknd 11964 14 of of IN cord-010119-t1x9gknd 11964 15 blood blood NN cord-010119-t1x9gknd 11964 16 . . . cord-010119-t1x9gknd 11965 1 There there EX cord-010119-t1x9gknd 11965 2 is be VBZ cord-010119-t1x9gknd 11965 3 an an DT cord-010119-t1x9gknd 11965 4 increased increase VBN cord-010119-t1x9gknd 11965 5 cost cost NN cord-010119-t1x9gknd 11965 6 associated associate VBN cord-010119-t1x9gknd 11965 7 with with IN cord-010119-t1x9gknd 11965 8 manufacturing manufacturing NN cord-010119-t1x9gknd 11965 9 FRBCs frbc NNS cord-010119-t1x9gknd 11965 10 which which WDT cord-010119-t1x9gknd 11965 11 is be VBZ cord-010119-t1x9gknd 11965 12 compensated compensate VBN cord-010119-t1x9gknd 11965 13 for for IN cord-010119-t1x9gknd 11965 14 by by IN cord-010119-t1x9gknd 11965 15 the the DT cord-010119-t1x9gknd 11965 16 longer long RBR cord-010119-t1x9gknd 11965 17 available available JJ cord-010119-t1x9gknd 11965 18 shelf shelf NN cord-010119-t1x9gknd 11965 19 life life NN cord-010119-t1x9gknd 11965 20 of of IN cord-010119-t1x9gknd 11965 21 10 10 CD cord-010119-t1x9gknd 11965 22 years year NNS cord-010119-t1x9gknd 11965 23 . . . cord-010119-t1x9gknd 11966 1 Having have VBG cord-010119-t1x9gknd 11966 2 a a DT cord-010119-t1x9gknd 11966 3 small small JJ cord-010119-t1x9gknd 11966 4 contingency contingency NN cord-010119-t1x9gknd 11966 5 supply supply NN cord-010119-t1x9gknd 11966 6 of of IN cord-010119-t1x9gknd 11966 7 frozen frozen JJ cord-010119-t1x9gknd 11966 8 red red JJ cord-010119-t1x9gknd 11966 9 cells cell NNS cord-010119-t1x9gknd 11966 10 and and CC cord-010119-t1x9gknd 11966 11 deglycerolization deglycerolization NN cord-010119-t1x9gknd 11966 12 equipment equipment NN cord-010119-t1x9gknd 11966 13 has have VBZ cord-010119-t1x9gknd 11966 14 been be VBN cord-010119-t1x9gknd 11966 15 effective effective JJ cord-010119-t1x9gknd 11966 16 on on IN cord-010119-t1x9gknd 11966 17 three three CD cord-010119-t1x9gknd 11966 18 occasions occasion NNS cord-010119-t1x9gknd 11966 19 in in IN cord-010119-t1x9gknd 11966 20 ensuring ensure VBG cord-010119-t1x9gknd 11966 21 availability availability NN cord-010119-t1x9gknd 11966 22 of of IN cord-010119-t1x9gknd 11966 23 type type NN cord-010119-t1x9gknd 11966 24 O o NN cord-010119-t1x9gknd 11966 25 red red JJ cord-010119-t1x9gknd 11966 26 blood blood NN cord-010119-t1x9gknd 11966 27 cells cell NNS cord-010119-t1x9gknd 11966 28 for for IN cord-010119-t1x9gknd 11966 29 hospital hospital NN cord-010119-t1x9gknd 11966 30 transfusion transfusion NN cord-010119-t1x9gknd 11966 31 services service NNS cord-010119-t1x9gknd 11966 32 . . . cord-010119-t1x9gknd 11967 1 Validation validation NN cord-010119-t1x9gknd 11967 2 of of IN cord-010119-t1x9gknd 11967 3 a a DT cord-010119-t1x9gknd 11967 4 Human Human NNP cord-010119-t1x9gknd 11967 5 Anti Anti NNP cord-010119-t1x9gknd 11967 6 - - NN cord-010119-t1x9gknd 11967 7 Tetanus Tetanus NNP cord-010119-t1x9gknd 11968 1 Toxoid Toxoid NNP cord-010119-t1x9gknd 11968 2 Immunoglobulin Immunoglobulin NNP cord-010119-t1x9gknd 11968 3 Assay Assay NNP cord-010119-t1x9gknd 11968 4 Performed perform VBN cord-010119-t1x9gknd 11968 5 on on IN cord-010119-t1x9gknd 11968 6 the the DT cord-010119-t1x9gknd 11968 7 Abbott Abbott NNP cord-010119-t1x9gknd 11968 8 c8000 c8000 NNP cord-010119-t1x9gknd 11968 9 Izekial Izekial NNP cord-010119-t1x9gknd 11968 10 Butler Butler NNP cord-010119-t1x9gknd 11968 11 * * NFP cord-010119-t1x9gknd 11968 12 1 1 CD cord-010119-t1x9gknd 11968 13 , , , cord-010119-t1x9gknd 11968 14 Karen Karen NNP cord-010119-t1x9gknd 11968 15 Leighton Leighton NNP cord-010119-t1x9gknd 11968 16 1 1 CD cord-010119-t1x9gknd 11968 17 , , , cord-010119-t1x9gknd 11968 18 Scott Scott NNP cord-010119-t1x9gknd 11968 19 Jones Jones NNP cord-010119-t1x9gknd 11968 20 1 1 CD cord-010119-t1x9gknd 11968 21 and and CC cord-010119-t1x9gknd 11968 22 Rachel Rachel NNP cord-010119-t1x9gknd 11968 23 Beddard Beddard NNP cord-010119-t1x9gknd 11968 24 2 2 CD cord-010119-t1x9gknd 11968 25 . . . cord-010119-t1x9gknd 11969 1 1 1 CD cord-010119-t1x9gknd 11969 2 QualTex QualTex NNP cord-010119-t1x9gknd 11969 3 Laboratories Laboratories NNPS cord-010119-t1x9gknd 11969 4 , , , cord-010119-t1x9gknd 11969 5 2 2 CD cord-010119-t1x9gknd 11969 6 BioBridge BioBridge NNP cord-010119-t1x9gknd 11969 7 Global Global NNP cord-010119-t1x9gknd 11969 8 Background Background NNP cord-010119-t1x9gknd 11969 9 / / SYM cord-010119-t1x9gknd 11969 10 Case Case NNP cord-010119-t1x9gknd 11969 11 Studies Studies NNPS cord-010119-t1x9gknd 11970 1 : : : cord-010119-t1x9gknd 11970 2 Plasma plasma NN cord-010119-t1x9gknd 11970 3 fractionators fractionator NNS cord-010119-t1x9gknd 11970 4 require require VBP cord-010119-t1x9gknd 11970 5 anti anti JJ cord-010119-t1x9gknd 11970 6 - - JJ cord-010119-t1x9gknd 11970 7 tetanus tetanus JJ cord-010119-t1x9gknd 11970 8 quantitative quantitative JJ cord-010119-t1x9gknd 11970 9 testing testing NN cord-010119-t1x9gknd 11970 10 to to TO cord-010119-t1x9gknd 11970 11 be be VB cord-010119-t1x9gknd 11970 12 performed perform VBN cord-010119-t1x9gknd 11970 13 on on IN cord-010119-t1x9gknd 11970 14 plasma plasma NN cord-010119-t1x9gknd 11970 15 samples sample NNS cord-010119-t1x9gknd 11970 16 collected collect VBN cord-010119-t1x9gknd 11970 17 from from IN cord-010119-t1x9gknd 11970 18 individual individual JJ cord-010119-t1x9gknd 11970 19 donors donor NNS cord-010119-t1x9gknd 11970 20 or or CC cord-010119-t1x9gknd 11970 21 plasma plasma NN cord-010119-t1x9gknd 11970 22 production production NN cord-010119-t1x9gknd 11970 23 pools pool NNS cord-010119-t1x9gknd 11970 24 . . . cord-010119-t1x9gknd 11971 1 This this DT cord-010119-t1x9gknd 11971 2 testing testing NN cord-010119-t1x9gknd 11971 3 serves serve VBZ cord-010119-t1x9gknd 11971 4 as as IN cord-010119-t1x9gknd 11971 5 a a DT cord-010119-t1x9gknd 11971 6 quality quality NN cord-010119-t1x9gknd 11971 7 control control NN cord-010119-t1x9gknd 11971 8 test test NN cord-010119-t1x9gknd 11971 9 and and CC cord-010119-t1x9gknd 11971 10 helps help VBZ cord-010119-t1x9gknd 11971 11 estimate estimate VB cord-010119-t1x9gknd 11971 12 the the DT cord-010119-t1x9gknd 11971 13 antibody antibody NN cord-010119-t1x9gknd 11971 14 potency potency NN cord-010119-t1x9gknd 11971 15 of of IN cord-010119-t1x9gknd 11971 16 the the DT cord-010119-t1x9gknd 11971 17 product product NN cord-010119-t1x9gknd 11971 18 . . . cord-010119-t1x9gknd 11972 1 The the DT cord-010119-t1x9gknd 11972 2 Binding Binding NNP cord-010119-t1x9gknd 11972 3 Site Site NNP cord-010119-t1x9gknd 11972 4 , , , cord-010119-t1x9gknd 11972 5 Human Human NNP cord-010119-t1x9gknd 11972 6 Anti Anti NNP cord-010119-t1x9gknd 11972 7 - - NNP cord-010119-t1x9gknd 11972 8 Tetanus Tetanus NNP cord-010119-t1x9gknd 11973 1 Toxoid Toxoid NNP cord-010119-t1x9gknd 11973 2 Immunoglobulin Immunoglobulin NNP cord-010119-t1x9gknd 11973 3 Liquid Liquid NNP cord-010119-t1x9gknd 11973 4 Reagent Reagent NNP cord-010119-t1x9gknd 11973 5 Kit kit NN cord-010119-t1x9gknd 11973 6 is be VBZ cord-010119-t1x9gknd 11973 7 for for IN cord-010119-t1x9gknd 11973 8 use use NN cord-010119-t1x9gknd 11973 9 on on IN cord-010119-t1x9gknd 11973 10 a a DT cord-010119-t1x9gknd 11973 11 turbidimetric turbidimetric JJ cord-010119-t1x9gknd 11973 12 analyzer analyzer NN cord-010119-t1x9gknd 11973 13 . . . cord-010119-t1x9gknd 11974 1 The the DT cord-010119-t1x9gknd 11974 2 aim aim NN cord-010119-t1x9gknd 11974 3 was be VBD cord-010119-t1x9gknd 11974 4 to to TO cord-010119-t1x9gknd 11974 5 optimize optimize VB cord-010119-t1x9gknd 11974 6 and and CC cord-010119-t1x9gknd 11974 7 validate validate VB cord-010119-t1x9gknd 11974 8 the the DT cord-010119-t1x9gknd 11974 9 Human Human NNP cord-010119-t1x9gknd 11974 10 Anti Anti NNP cord-010119-t1x9gknd 11974 11 - - NNP cord-010119-t1x9gknd 11974 12 Tetanus Tetanus NNP cord-010119-t1x9gknd 11974 13 Toxoid Toxoid NNP cord-010119-t1x9gknd 11974 14 Immunoglobulin Immunoglobulin NNP cord-010119-t1x9gknd 11974 15 Liquid Liquid NNP cord-010119-t1x9gknd 11974 16 Reagent Reagent NNP cord-010119-t1x9gknd 11974 17 Kit kit NN cord-010119-t1x9gknd 11974 18 for for IN cord-010119-t1x9gknd 11974 19 use use NN cord-010119-t1x9gknd 11974 20 on on IN cord-010119-t1x9gknd 11974 21 a a DT cord-010119-t1x9gknd 11974 22 photometric photometric JJ cord-010119-t1x9gknd 11974 23 analyzer analyzer NN cord-010119-t1x9gknd 11974 24 . . . cord-010119-t1x9gknd 11975 1 Study Study NNP cord-010119-t1x9gknd 11975 2 Design Design NNP cord-010119-t1x9gknd 11975 3 / / SYM cord-010119-t1x9gknd 11975 4 Method method NN cord-010119-t1x9gknd 11975 5 : : : cord-010119-t1x9gknd 11976 1 Experiments experiment NNS cord-010119-t1x9gknd 11976 2 were be VBD cord-010119-t1x9gknd 11976 3 performed perform VBN cord-010119-t1x9gknd 11976 4 in in IN cord-010119-t1x9gknd 11976 5 order order NN cord-010119-t1x9gknd 11976 6 to to TO cord-010119-t1x9gknd 11976 7 determine determine VB cord-010119-t1x9gknd 11976 8 the the DT cord-010119-t1x9gknd 11976 9 optimal optimal JJ cord-010119-t1x9gknd 11976 10 amount amount NN cord-010119-t1x9gknd 11976 11 required require VBN cord-010119-t1x9gknd 11976 12 of of IN cord-010119-t1x9gknd 11976 13 reagent reagent JJ cord-010119-t1x9gknd 11976 14 buffer buffer NN cord-010119-t1x9gknd 11976 15 and and CC cord-010119-t1x9gknd 11976 16 latex latex NN cord-010119-t1x9gknd 11976 17 reagent reagent NN cord-010119-t1x9gknd 11976 18 from from IN cord-010119-t1x9gknd 11976 19 the the DT cord-010119-t1x9gknd 11976 20 anti anti NN cord-010119-t1x9gknd 11976 21 - - JJ cord-010119-t1x9gknd 11976 22 Tetanus tetanus JJ cord-010119-t1x9gknd 11977 1 Toxoid toxoid NN cord-010119-t1x9gknd 11977 2 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 11977 3 kit kit NN cord-010119-t1x9gknd 11977 4 utilizing utilize VBG cord-010119-t1x9gknd 11977 5 the the DT cord-010119-t1x9gknd 11977 6 Abbott Abbott NNP cord-010119-t1x9gknd 11977 7 c8000 c8000 NNP cord-010119-t1x9gknd 11977 8 instrument instrument NN cord-010119-t1x9gknd 11977 9 . . . cord-010119-t1x9gknd 11978 1 Precision precision NN cord-010119-t1x9gknd 11978 2 of of IN cord-010119-t1x9gknd 11978 3 the the DT cord-010119-t1x9gknd 11978 4 new new JJ cord-010119-t1x9gknd 11978 5 assay assay NN cord-010119-t1x9gknd 11978 6 parameters parameter NNS cord-010119-t1x9gknd 11978 7 was be VBD cord-010119-t1x9gknd 11978 8 determined determine VBN cord-010119-t1x9gknd 11978 9 by by IN cord-010119-t1x9gknd 11978 10 testing test VBG cord-010119-t1x9gknd 11978 11 10 10 CD cord-010119-t1x9gknd 11978 12 replicates replicate NNS cord-010119-t1x9gknd 11978 13 of of IN cord-010119-t1x9gknd 11978 14 a a DT cord-010119-t1x9gknd 11978 15 panel panel NN cord-010119-t1x9gknd 11978 16 of of IN cord-010119-t1x9gknd 11978 17 samples sample NNS cord-010119-t1x9gknd 11978 18 at at IN cord-010119-t1x9gknd 11978 19 three three CD cord-010119-t1x9gknd 11978 20 concentrations concentration NNS cord-010119-t1x9gknd 11978 21 of of IN cord-010119-t1x9gknd 11978 22 tetanus tetanus JJ cord-010119-t1x9gknd 11978 23 antibody antibody NN cord-010119-t1x9gknd 11978 24 in in IN cord-010119-t1x9gknd 11978 25 a a DT cord-010119-t1x9gknd 11978 26 single single JJ cord-010119-t1x9gknd 11978 27 testing testing NN cord-010119-t1x9gknd 11978 28 run run NN cord-010119-t1x9gknd 11978 29 . . . cord-010119-t1x9gknd 11979 1 The the DT cord-010119-t1x9gknd 11979 2 panel panel NN cord-010119-t1x9gknd 11979 3 samples sample NNS cord-010119-t1x9gknd 11979 4 were be VBD cord-010119-t1x9gknd 11979 5 created create VBN cord-010119-t1x9gknd 11979 6 by by IN cord-010119-t1x9gknd 11979 7 spiking spike VBG cord-010119-t1x9gknd 11979 8 appropriate appropriate JJ cord-010119-t1x9gknd 11979 9 amount amount NN cord-010119-t1x9gknd 11979 10 of of IN cord-010119-t1x9gknd 11979 11 a a DT cord-010119-t1x9gknd 11979 12 WHO who WP cord-010119-t1x9gknd 11979 13 tetanus tetanus JJ cord-010119-t1x9gknd 11979 14 antibody antibody NN cord-010119-t1x9gknd 11979 15 standard standard NN cord-010119-t1x9gknd 11979 16 into into IN cord-010119-t1x9gknd 11979 17 Sodium Sodium NNP cord-010119-t1x9gknd 11979 18 Citrate Citrate NNP cord-010119-t1x9gknd 11979 19 plasma plasma NN cord-010119-t1x9gknd 11979 20 . . . cord-010119-t1x9gknd 11980 1 Accuracy accuracy NN cord-010119-t1x9gknd 11980 2 was be VBD cord-010119-t1x9gknd 11980 3 determined determine VBN cord-010119-t1x9gknd 11980 4 by by IN cord-010119-t1x9gknd 11980 5 testing test VBG cord-010119-t1x9gknd 11980 6 a a DT cord-010119-t1x9gknd 11980 7 series series NN cord-010119-t1x9gknd 11980 8 of of IN cord-010119-t1x9gknd 11980 9 samples sample NNS cord-010119-t1x9gknd 11980 10 ranging range VBG cord-010119-t1x9gknd 11980 11 from from IN cord-010119-t1x9gknd 11980 12 1 1 CD cord-010119-t1x9gknd 11980 13 IU IU NNP cord-010119-t1x9gknd 11980 14 / / , cord-010119-t1x9gknd 11980 15 mL ml NN cord-010119-t1x9gknd 11980 16 to to IN cord-010119-t1x9gknd 11980 17 60 60 CD cord-010119-t1x9gknd 11980 18 IU IU NNP cord-010119-t1x9gknd 11980 19 / / SYM cord-010119-t1x9gknd 11980 20 mL ml NN cord-010119-t1x9gknd 11980 21 of of IN cord-010119-t1x9gknd 11980 22 tetanus tetanus JJ cord-010119-t1x9gknd 11980 23 antibody antibody NN cord-010119-t1x9gknd 11980 24 . . . cord-010119-t1x9gknd 11981 1 The the DT cord-010119-t1x9gknd 11981 2 samples sample NNS cord-010119-t1x9gknd 11981 3 for for IN cord-010119-t1x9gknd 11981 4 the the DT cord-010119-t1x9gknd 11981 5 accuracy accuracy NN cord-010119-t1x9gknd 11981 6 study study NN cord-010119-t1x9gknd 11981 7 were be VBD cord-010119-t1x9gknd 11981 8 created create VBN cord-010119-t1x9gknd 11981 9 by by IN cord-010119-t1x9gknd 11981 10 diluting dilute VBG cord-010119-t1x9gknd 11981 11 an an DT cord-010119-t1x9gknd 11981 12 appropriate appropriate JJ cord-010119-t1x9gknd 11981 13 amount amount NN cord-010119-t1x9gknd 11981 14 of of IN cord-010119-t1x9gknd 11981 15 a a DT cord-010119-t1x9gknd 11981 16 WHO who WP cord-010119-t1x9gknd 11981 17 tetanus tetanus JJ cord-010119-t1x9gknd 11981 18 antibody antibody NN cord-010119-t1x9gknd 11981 19 standard standard NN cord-010119-t1x9gknd 11981 20 with with IN cord-010119-t1x9gknd 11981 21 sample sample NN cord-010119-t1x9gknd 11981 22 diluent diluent NN cord-010119-t1x9gknd 11981 23 from from IN cord-010119-t1x9gknd 11981 24 the the DT cord-010119-t1x9gknd 11981 25 reagent reagent NN cord-010119-t1x9gknd 11981 26 kit kit NN cord-010119-t1x9gknd 11981 27 . . . cord-010119-t1x9gknd 11982 1 Linearity linearity NN cord-010119-t1x9gknd 11982 2 regression regression NN cord-010119-t1x9gknd 11982 3 was be VBD cord-010119-t1x9gknd 11982 4 determined determine VBN cord-010119-t1x9gknd 11982 5 by by IN cord-010119-t1x9gknd 11982 6 using use VBG cord-010119-t1x9gknd 11982 7 the the DT cord-010119-t1x9gknd 11982 8 accuracy accuracy NN cord-010119-t1x9gknd 11982 9 study study NN cord-010119-t1x9gknd 11982 10 values value NNS cord-010119-t1x9gknd 11982 11 within within IN cord-010119-t1x9gknd 11982 12 the the DT cord-010119-t1x9gknd 11982 13 range range NN cord-010119-t1x9gknd 11982 14 of of IN cord-010119-t1x9gknd 11982 15 2.0 2.0 CD cord-010119-t1x9gknd 11982 16 to to IN cord-010119-t1x9gknd 11982 17 45.0 45.0 CD cord-010119-t1x9gknd 11982 18 IU IU NNP cord-010119-t1x9gknd 11982 19 / / SYM cord-010119-t1x9gknd 11982 20 mL. ml. NN cord-010119-t1x9gknd 11982 21 Stability stability NN cord-010119-t1x9gknd 11982 22 of of IN cord-010119-t1x9gknd 11982 23 samples sample NNS cord-010119-t1x9gknd 11982 24 was be VBD cord-010119-t1x9gknd 11982 25 determined determine VBN cord-010119-t1x9gknd 11982 26 by by IN cord-010119-t1x9gknd 11982 27 testing test VBG cord-010119-t1x9gknd 11982 28 samples sample NNS cord-010119-t1x9gknd 11982 29 stored store VBN cord-010119-t1x9gknd 11982 30 at at IN cord-010119-t1x9gknd 11982 31 2 2 CD cord-010119-t1x9gknd 11982 32 - - SYM cord-010119-t1x9gknd 11982 33 8 8 CD cord-010119-t1x9gknd 11982 34 0 0 CD cord-010119-t1x9gknd 11982 35 C c NN cord-010119-t1x9gknd 11982 36 and and CC cord-010119-t1x9gknd 11982 37 -20 -20 NN cord-010119-t1x9gknd 11982 38 0 0 NFP cord-010119-t1x9gknd 11982 39 C c NN cord-010119-t1x9gknd 11982 40 in in IN cord-010119-t1x9gknd 11982 41 triplicate triplicate NN cord-010119-t1x9gknd 11982 42 at at IN cord-010119-t1x9gknd 11982 43 various various JJ cord-010119-t1x9gknd 11982 44 time time NN cord-010119-t1x9gknd 11982 45 intervals interval NNS cord-010119-t1x9gknd 11982 46 . . . cord-010119-t1x9gknd 11983 1 Results result NNS cord-010119-t1x9gknd 11983 2 / / SYM cord-010119-t1x9gknd 11983 3 Finding finding NN cord-010119-t1x9gknd 11983 4 : : : cord-010119-t1x9gknd 11983 5 The the DT cord-010119-t1x9gknd 11983 6 % % NN cord-010119-t1x9gknd 11983 7 CV cv NN cord-010119-t1x9gknd 11983 8 for for IN cord-010119-t1x9gknd 11983 9 the the DT cord-010119-t1x9gknd 11983 10 optimized optimize VBN cord-010119-t1x9gknd 11983 11 anti anti NN cord-010119-t1x9gknd 11983 12 - - JJ cord-010119-t1x9gknd 11983 13 tetanus tetanus JJ cord-010119-t1x9gknd 11983 14 assay assay NN cord-010119-t1x9gknd 11983 15 for for IN cord-010119-t1x9gknd 11983 16 all all DT cord-010119-t1x9gknd 11983 17 antibody antibody NN cord-010119-t1x9gknd 11983 18 levels level NNS cord-010119-t1x9gknd 11983 19 determined determine VBN cord-010119-t1x9gknd 11983 20 in in IN cord-010119-t1x9gknd 11983 21 the the DT cord-010119-t1x9gknd 11983 22 precision precision NN cord-010119-t1x9gknd 11983 23 study study NN cord-010119-t1x9gknd 11983 24 varied varied JJ cord-010119-t1x9gknd 11983 25 from from IN cord-010119-t1x9gknd 11983 26 1.2855 1.2855 CD cord-010119-t1x9gknd 11983 27 to to IN cord-010119-t1x9gknd 11983 28 1.3142 1.3142 CD cord-010119-t1x9gknd 11983 29 . . . cord-010119-t1x9gknd 11984 1 So so RB cord-010119-t1x9gknd 11984 2 , , , cord-010119-t1x9gknd 11984 3 precision precision NN cord-010119-t1x9gknd 11984 4 was be VBD cord-010119-t1x9gknd 11984 5 acceptable acceptable JJ cord-010119-t1x9gknd 11984 6 since since IN cord-010119-t1x9gknd 11984 7 the the DT cord-010119-t1x9gknd 11984 8 % % NN cord-010119-t1x9gknd 11984 9 CV cv NN cord-010119-t1x9gknd 11984 10 for for IN cord-010119-t1x9gknd 11984 11 all all DT cord-010119-t1x9gknd 11984 12 samples sample NNS cord-010119-t1x9gknd 11984 13 tested test VBN cord-010119-t1x9gknd 11984 14 was be VBD cord-010119-t1x9gknd 11984 15 5 5 CD cord-010119-t1x9gknd 11984 16 % % NN cord-010119-t1x9gknd 11984 17 . . . cord-010119-t1x9gknd 11985 1 The the DT cord-010119-t1x9gknd 11985 2 mean mean JJ cord-010119-t1x9gknd 11985 3 values value NNS cord-010119-t1x9gknd 11985 4 for for IN cord-010119-t1x9gknd 11985 5 the the DT cord-010119-t1x9gknd 11985 6 samples sample NNS cord-010119-t1x9gknd 11985 7 tested test VBN cord-010119-t1x9gknd 11985 8 in in IN cord-010119-t1x9gknd 11985 9 the the DT cord-010119-t1x9gknd 11985 10 accuracy accuracy NN cord-010119-t1x9gknd 11985 11 study study NN cord-010119-t1x9gknd 11985 12 were be VBD cord-010119-t1x9gknd 11985 13 all all DT cord-010119-t1x9gknd 11985 14 610 610 CD cord-010119-t1x9gknd 11985 15 % % NN cord-010119-t1x9gknd 11985 16 of of IN cord-010119-t1x9gknd 11985 17 the the DT cord-010119-t1x9gknd 11985 18 expected expect VBN cord-010119-t1x9gknd 11985 19 value value NN cord-010119-t1x9gknd 11985 20 which which WDT cord-010119-t1x9gknd 11985 21 was be VBD cord-010119-t1x9gknd 11985 22 much much RB cord-010119-t1x9gknd 11985 23 lower low JJR cord-010119-t1x9gknd 11985 24 than than IN cord-010119-t1x9gknd 11985 25 the the DT cord-010119-t1x9gknd 11985 26 acceptance acceptance NN cord-010119-t1x9gknd 11985 27 criteria criterion NNS cord-010119-t1x9gknd 11985 28 which which WDT cord-010119-t1x9gknd 11985 29 was be VBD cord-010119-t1x9gknd 11985 30 615 615 CD cord-010119-t1x9gknd 11985 31 % % NN cord-010119-t1x9gknd 11985 32 of of IN cord-010119-t1x9gknd 11985 33 the the DT cord-010119-t1x9gknd 11985 34 expected expect VBN cord-010119-t1x9gknd 11985 35 value value NN cord-010119-t1x9gknd 11985 36 . . . cord-010119-t1x9gknd 11986 1 The the DT cord-010119-t1x9gknd 11986 2 linearity linearity NN cord-010119-t1x9gknd 11986 3 of of IN cord-010119-t1x9gknd 11986 4 the the DT cord-010119-t1x9gknd 11986 5 assay assay NN cord-010119-t1x9gknd 11986 6 was be VBD cord-010119-t1x9gknd 11986 7 acceptable acceptable JJ cord-010119-t1x9gknd 11986 8 with with IN cord-010119-t1x9gknd 11986 9 a a DT cord-010119-t1x9gknd 11986 10 R2 r2 NN cord-010119-t1x9gknd 11986 11 ! ! . cord-010119-t1x9gknd 11987 1 99.0 99.0 CD cord-010119-t1x9gknd 11987 2 % % NN cord-010119-t1x9gknd 11987 3 . . . cord-010119-t1x9gknd 11988 1 The the DT cord-010119-t1x9gknd 11988 2 linearity linearity NN cord-010119-t1x9gknd 11988 3 study study NN cord-010119-t1x9gknd 11988 4 established establish VBD cord-010119-t1x9gknd 11988 5 that that IN cord-010119-t1x9gknd 11988 6 the the DT cord-010119-t1x9gknd 11988 7 known know VBN cord-010119-t1x9gknd 11988 8 tetanus tetanus JJ cord-010119-t1x9gknd 11988 9 concentration concentration NN cord-010119-t1x9gknd 11988 10 was be VBD cord-010119-t1x9gknd 11988 11 a a DT cord-010119-t1x9gknd 11988 12 statistically statistically RB cord-010119-t1x9gknd 11988 13 significant significant JJ cord-010119-t1x9gknd 11988 14 predictor predictor NN cord-010119-t1x9gknd 11988 15 of of IN cord-010119-t1x9gknd 11988 16 the the DT cord-010119-t1x9gknd 11988 17 observed observed JJ cord-010119-t1x9gknd 11988 18 concentration concentration NN cord-010119-t1x9gknd 11988 19 . . . cord-010119-t1x9gknd 11989 1 The the DT cord-010119-t1x9gknd 11989 2 sample sample NN cord-010119-t1x9gknd 11989 3 stability stability NN cord-010119-t1x9gknd 11989 4 studies study NNS cord-010119-t1x9gknd 11989 5 demonstrated demonstrate VBD cord-010119-t1x9gknd 11989 6 the the DT cord-010119-t1x9gknd 11989 7 ability ability NN cord-010119-t1x9gknd 11989 8 to to TO cord-010119-t1x9gknd 11989 9 quantitate quantitate VB cord-010119-t1x9gknd 11989 10 tetanus tetanus JJ cord-010119-t1x9gknd 11989 11 antibody antibody NN cord-010119-t1x9gknd 11989 12 concentrations concentration NNS cord-010119-t1x9gknd 11989 13 in in IN cord-010119-t1x9gknd 11989 14 samples sample NNS cord-010119-t1x9gknd 11989 15 stored store VBN cord-010119-t1x9gknd 11989 16 up up RP cord-010119-t1x9gknd 11989 17 to to TO cord-010119-t1x9gknd 11989 18 14 14 CD cord-010119-t1x9gknd 11989 19 days day NNS cord-010119-t1x9gknd 11989 20 at at IN cord-010119-t1x9gknd 11989 21 2 2 CD cord-010119-t1x9gknd 11989 22 - - SYM cord-010119-t1x9gknd 11989 23 8 8 CD cord-010119-t1x9gknd 11989 24 0 0 CD cord-010119-t1x9gknd 11989 25 C c NN cord-010119-t1x9gknd 11989 26 and and CC cord-010119-t1x9gknd 11989 27 up up IN cord-010119-t1x9gknd 11989 28 to to TO cord-010119-t1x9gknd 11989 29 1 1 CD cord-010119-t1x9gknd 11989 30 month month NN cord-010119-t1x9gknd 11989 31 at at IN cord-010119-t1x9gknd 11989 32 -20 -20 CD cord-010119-t1x9gknd 11989 33 0 0 NFP cord-010119-t1x9gknd 11989 34 C. C. NNP cord-010119-t1x9gknd 11989 35 Conclusion conclusion NN cord-010119-t1x9gknd 11989 36 : : : cord-010119-t1x9gknd 11990 1 The the DT cord-010119-t1x9gknd 11990 2 data datum NNS cord-010119-t1x9gknd 11990 3 presented present VBD cord-010119-t1x9gknd 11990 4 shows show VBZ cord-010119-t1x9gknd 11990 5 the the DT cord-010119-t1x9gknd 11990 6 successful successful JJ cord-010119-t1x9gknd 11990 7 optimization optimization NN cord-010119-t1x9gknd 11990 8 of of IN cord-010119-t1x9gknd 11990 9 the the DT cord-010119-t1x9gknd 11990 10 Human Human NNP cord-010119-t1x9gknd 11990 11 Anti Anti NNP cord-010119-t1x9gknd 11990 12 - - NNP cord-010119-t1x9gknd 11990 13 Tetanus Tetanus NNP cord-010119-t1x9gknd 11990 14 Immunoglobulin Immunoglobulin NNP cord-010119-t1x9gknd 11990 15 Reagent Reagent NNP cord-010119-t1x9gknd 11990 16 Kit kit NN cord-010119-t1x9gknd 11990 17 for for IN cord-010119-t1x9gknd 11990 18 use use NN cord-010119-t1x9gknd 11990 19 on on IN cord-010119-t1x9gknd 11990 20 a a DT cord-010119-t1x9gknd 11990 21 photometric photometric JJ cord-010119-t1x9gknd 11990 22 analyzer analyzer NN cord-010119-t1x9gknd 11990 23 . . . cord-010119-t1x9gknd 11991 1 Validation validation NN cord-010119-t1x9gknd 11991 2 studies study NNS cord-010119-t1x9gknd 11991 3 of of IN cord-010119-t1x9gknd 11991 4 this this DT cord-010119-t1x9gknd 11991 5 optimized optimize VBN cord-010119-t1x9gknd 11991 6 assay assay NN cord-010119-t1x9gknd 11991 7 demonstrate demonstrate VBP cord-010119-t1x9gknd 11991 8 excellent excellent JJ cord-010119-t1x9gknd 11991 9 accuracy accuracy NN cord-010119-t1x9gknd 11991 10 , , , cord-010119-t1x9gknd 11991 11 precision precision NN cord-010119-t1x9gknd 11991 12 and and CC cord-010119-t1x9gknd 11991 13 linearity linearity NN cord-010119-t1x9gknd 11991 14 using use VBG cord-010119-t1x9gknd 11991 15 samples sample NNS cord-010119-t1x9gknd 11991 16 stored store VBN cord-010119-t1x9gknd 11991 17 for for IN cord-010119-t1x9gknd 11991 18 14 14 CD cord-010119-t1x9gknd 11991 19 days day NNS cord-010119-t1x9gknd 11991 20 at at IN cord-010119-t1x9gknd 11991 21 2 2 CD cord-010119-t1x9gknd 11991 22 - - SYM cord-010119-t1x9gknd 11991 23 8 8 CD cord-010119-t1x9gknd 11991 24 0 0 CD cord-010119-t1x9gknd 11991 25 C c NN cord-010119-t1x9gknd 11991 26 and and CC cord-010119-t1x9gknd 11991 27 stored store VBN cord-010119-t1x9gknd 11991 28 up up RP cord-010119-t1x9gknd 11991 29 to to IN cord-010119-t1x9gknd 11991 30 one one CD cord-010119-t1x9gknd 11991 31 month month NN cord-010119-t1x9gknd 11991 32 at at IN cord-010119-t1x9gknd 11991 33 -20 -20 CD cord-010119-t1x9gknd 11991 34 0 0 NFP cord-010119-t1x9gknd 11992 1 C. C. NNP cord-010119-t1x9gknd 11992 2 A A NNP cord-010119-t1x9gknd 11992 3 Deep Deep NNP cord-010119-t1x9gknd 11992 4 Dive Dive NNP cord-010119-t1x9gknd 11992 5 Audit Audit NNP cord-010119-t1x9gknd 11992 6 of of IN cord-010119-t1x9gknd 11992 7 Intravenous Intravenous NNP cord-010119-t1x9gknd 11992 8 Immunoglobulin Immunoglobulin NNP cord-010119-t1x9gknd 11992 9 Use Use NNP cord-010119-t1x9gknd 11992 10 for for IN cord-010119-t1x9gknd 11992 11 immune immune JJ cord-010119-t1x9gknd 11992 12 Thrombocytopenia Thrombocytopenia NNP cord-010119-t1x9gknd 11992 13 : : : cord-010119-t1x9gknd 11993 1 Is be VBZ cord-010119-t1x9gknd 11993 2 Its -PRON- PRP$ cord-010119-t1x9gknd 11993 3 Use Use NNP cord-010119-t1x9gknd 11993 4 Inappropriate inappropriate JJ cord-010119-t1x9gknd 11993 5 ? ? . cord-010119-t1x9gknd 11994 1 Jiajia Jiajia NNP cord-010119-t1x9gknd 11994 2 Liu Liu NNP cord-010119-t1x9gknd 11995 1 * * NFP cord-010119-t1x9gknd 11995 2 . . . cord-010119-t1x9gknd 11996 1 University University NNP cord-010119-t1x9gknd 11996 2 of of IN cord-010119-t1x9gknd 11996 3 Toronto Toronto NNP cord-010119-t1x9gknd 11996 4 Background Background NNP cord-010119-t1x9gknd 11996 5 / / SYM cord-010119-t1x9gknd 11996 6 Case Case NNP cord-010119-t1x9gknd 11996 7 Studies Studies NNPS cord-010119-t1x9gknd 11996 8 : : : cord-010119-t1x9gknd 11997 1 Intravenous intravenous JJ cord-010119-t1x9gknd 11997 2 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 11997 3 ( ( -LRB- cord-010119-t1x9gknd 11997 4 IVIG IVIG NNP cord-010119-t1x9gknd 11997 5 ) ) -RRB- cord-010119-t1x9gknd 11997 6 is be VBZ cord-010119-t1x9gknd 11997 7 a a DT cord-010119-t1x9gknd 11997 8 generally generally RB cord-010119-t1x9gknd 11997 9 safe safe JJ cord-010119-t1x9gknd 11997 10 and and CC cord-010119-t1x9gknd 11997 11 effective effective JJ cord-010119-t1x9gknd 11997 12 therapy therapy NN cord-010119-t1x9gknd 11997 13 for for IN cord-010119-t1x9gknd 11997 14 immune immune JJ cord-010119-t1x9gknd 11997 15 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 11997 16 ( ( -LRB- cord-010119-t1x9gknd 11997 17 ITP ITP NNP cord-010119-t1x9gknd 11997 18 ) ) -RRB- cord-010119-t1x9gknd 11997 19 but but CC cord-010119-t1x9gknd 11997 20 is be VBZ cord-010119-t1x9gknd 11997 21 only only RB cord-010119-t1x9gknd 11997 22 suggested suggest VBN cord-010119-t1x9gknd 11997 23 for for IN cord-010119-t1x9gknd 11997 24 scenarios scenario NNS cord-010119-t1x9gknd 11997 25 when when WRB cord-010119-t1x9gknd 11997 26 a a DT cord-010119-t1x9gknd 11997 27 rapid rapid JJ cord-010119-t1x9gknd 11997 28 increase increase NN cord-010119-t1x9gknd 11997 29 in in IN cord-010119-t1x9gknd 11997 30 platelet platelet NN cord-010119-t1x9gknd 11997 31 count count NN cord-010119-t1x9gknd 11997 32 is be VBZ cord-010119-t1x9gknd 11997 33 desired desire VBN cord-010119-t1x9gknd 11997 34 or or CC cord-010119-t1x9gknd 11997 35 as as IN cord-010119-t1x9gknd 11997 36 first first JJ cord-010119-t1x9gknd 11997 37 line line NN cord-010119-t1x9gknd 11997 38 therapy therapy NN cord-010119-t1x9gknd 11997 39 if if IN cord-010119-t1x9gknd 11997 40 steroids steroid NNS cord-010119-t1x9gknd 11997 41 are be VBP cord-010119-t1x9gknd 11997 42 contraindicated contraindicated JJ cord-010119-t1x9gknd 11997 43 . . . cord-010119-t1x9gknd 11998 1 Due due IN cord-010119-t1x9gknd 11998 2 to to IN cord-010119-t1x9gknd 11998 3 concerns concern NNS cord-010119-t1x9gknd 11998 4 regarding regard VBG cord-010119-t1x9gknd 11998 5 adverse adverse JJ cord-010119-t1x9gknd 11998 6 effects effect NNS cord-010119-t1x9gknd 11998 7 , , , cord-010119-t1x9gknd 11998 8 cost cost NN cord-010119-t1x9gknd 11998 9 and and CC cord-010119-t1x9gknd 11998 10 resource resource NN cord-010119-t1x9gknd 11998 11 availability availability NN cord-010119-t1x9gknd 11998 12 , , , cord-010119-t1x9gknd 11998 13 an an DT cord-010119-t1x9gknd 11998 14 IVIG IVIG NNP cord-010119-t1x9gknd 11998 15 request request NN cord-010119-t1x9gknd 11998 16 form form NN cord-010119-t1x9gknd 11998 17 was be VBD cord-010119-t1x9gknd 11998 18 implemented implement VBN cord-010119-t1x9gknd 11998 19 in in IN cord-010119-t1x9gknd 11998 20 our -PRON- PRP$ cord-010119-t1x9gknd 11998 21 jurisdiction jurisdiction NN cord-010119-t1x9gknd 11998 22 in in IN cord-010119-t1x9gknd 11998 23 2010 2010 CD cord-010119-t1x9gknd 11998 24 to to TO cord-010119-t1x9gknd 11998 25 track track VB cord-010119-t1x9gknd 11998 26 utilization utilization NN cord-010119-t1x9gknd 11998 27 and and CC cord-010119-t1x9gknd 11998 28 appropriateness appropriateness NN cord-010119-t1x9gknd 11998 29 . . . cord-010119-t1x9gknd 11999 1 A a DT cord-010119-t1x9gknd 11999 2 recent recent JJ cord-010119-t1x9gknd 11999 3 audit audit NN cord-010119-t1x9gknd 11999 4 of of IN cord-010119-t1x9gknd 11999 5 these these DT cord-010119-t1x9gknd 11999 6 request request NN cord-010119-t1x9gknd 11999 7 forms form NNS cord-010119-t1x9gknd 11999 8 from from IN cord-010119-t1x9gknd 11999 9 four four CD cord-010119-t1x9gknd 11999 10 academic academic JJ cord-010119-t1x9gknd 11999 11 institutions institution NNS cord-010119-t1x9gknd 11999 12 found find VBD cord-010119-t1x9gknd 11999 13 a a DT cord-010119-t1x9gknd 11999 14 lack lack NN cord-010119-t1x9gknd 11999 15 of of IN cord-010119-t1x9gknd 11999 16 compliance compliance NN cord-010119-t1x9gknd 11999 17 with with IN cord-010119-t1x9gknd 11999 18 form form NN cord-010119-t1x9gknd 11999 19 requirements requirement NNS cord-010119-t1x9gknd 11999 20 and and CC cord-010119-t1x9gknd 11999 21 inadequate inadequate JJ cord-010119-t1x9gknd 11999 22 documentation documentation NN cord-010119-t1x9gknd 11999 23 of of IN cord-010119-t1x9gknd 11999 24 efficacy efficacy NN cord-010119-t1x9gknd 11999 25 which which WDT cord-010119-t1x9gknd 11999 26 led lead VBD cord-010119-t1x9gknd 11999 27 the the DT cord-010119-t1x9gknd 11999 28 authors author NNS cord-010119-t1x9gknd 11999 29 to to TO cord-010119-t1x9gknd 11999 30 conclude conclude VB cord-010119-t1x9gknd 11999 31 that that IN cord-010119-t1x9gknd 11999 32 the the DT cord-010119-t1x9gknd 11999 33 use use NN cord-010119-t1x9gknd 11999 34 of of IN cord-010119-t1x9gknd 11999 35 IVIG IVIG NNP cord-010119-t1x9gknd 11999 36 was be VBD cord-010119-t1x9gknd 11999 37 broadly broadly RB cord-010119-t1x9gknd 11999 38 inappropriate inappropriate JJ cord-010119-t1x9gknd 11999 39 ( ( -LRB- cord-010119-t1x9gknd 11999 40 Shih Shih NNP cord-010119-t1x9gknd 11999 41 et et FW cord-010119-t1x9gknd 11999 42 al al NNP cord-010119-t1x9gknd 11999 43 , , , cord-010119-t1x9gknd 11999 44 2017 2017 CD cord-010119-t1x9gknd 11999 45 ) ) -RRB- cord-010119-t1x9gknd 11999 46 . . . cord-010119-t1x9gknd 12000 1 As as IN cord-010119-t1x9gknd 12000 2 such such JJ cord-010119-t1x9gknd 12000 3 , , , cord-010119-t1x9gknd 12000 4 we -PRON- PRP cord-010119-t1x9gknd 12000 5 aimed aim VBD cord-010119-t1x9gknd 12000 6 to to TO cord-010119-t1x9gknd 12000 7 conduct conduct VB cord-010119-t1x9gknd 12000 8 an an DT cord-010119-t1x9gknd 12000 9 extensive extensive JJ cord-010119-t1x9gknd 12000 10 chart chart NN cord-010119-t1x9gknd 12000 11 review review NN cord-010119-t1x9gknd 12000 12 of of IN cord-010119-t1x9gknd 12000 13 patients patient NNS cord-010119-t1x9gknd 12000 14 who who WP cord-010119-t1x9gknd 12000 15 received receive VBD cord-010119-t1x9gknd 12000 16 IVIG IVIG NNP cord-010119-t1x9gknd 12000 17 for for IN cord-010119-t1x9gknd 12000 18 ITP ITP NNP cord-010119-t1x9gknd 12000 19 at at IN cord-010119-t1x9gknd 12000 20 our -PRON- PRP$ cord-010119-t1x9gknd 12000 21 institution institution NN cord-010119-t1x9gknd 12000 22 to to TO cord-010119-t1x9gknd 12000 23 assess assess VB cord-010119-t1x9gknd 12000 24 appropriateness appropriateness NN cord-010119-t1x9gknd 12000 25 of of IN cord-010119-t1x9gknd 12000 26 use use NN cord-010119-t1x9gknd 12000 27 . . . cord-010119-t1x9gknd 12001 1 Study Study NNP cord-010119-t1x9gknd 12001 2 Design Design NNP cord-010119-t1x9gknd 12001 3 / / SYM cord-010119-t1x9gknd 12001 4 Method method NN cord-010119-t1x9gknd 12001 5 : : : cord-010119-t1x9gknd 12001 6 We -PRON- PRP cord-010119-t1x9gknd 12001 7 conducted conduct VBD cord-010119-t1x9gknd 12001 8 a a DT cord-010119-t1x9gknd 12001 9 retrospective retrospective JJ cord-010119-t1x9gknd 12001 10 chart chart NN cord-010119-t1x9gknd 12001 11 review review NN cord-010119-t1x9gknd 12001 12 of of IN cord-010119-t1x9gknd 12001 13 all all DT cord-010119-t1x9gknd 12001 14 patients patient NNS cord-010119-t1x9gknd 12001 15 with with IN cord-010119-t1x9gknd 12001 16 ITP ITP NNP cord-010119-t1x9gknd 12001 17 who who WP cord-010119-t1x9gknd 12001 18 received receive VBD cord-010119-t1x9gknd 12001 19 IVIG IVIG NNP cord-010119-t1x9gknd 12001 20 in in IN cord-010119-t1x9gknd 12001 21 our -PRON- PRP$ cord-010119-t1x9gknd 12001 22 institution institution NN cord-010119-t1x9gknd 12001 23 from from IN cord-010119-t1x9gknd 12001 24 April April NNP cord-010119-t1x9gknd 12001 25 1 1 CD cord-010119-t1x9gknd 12001 26 , , , cord-010119-t1x9gknd 12001 27 2014 2014 CD cord-010119-t1x9gknd 12001 28 to to IN cord-010119-t1x9gknd 12001 29 March March NNP cord-010119-t1x9gknd 12001 30 31 31 CD cord-010119-t1x9gknd 12001 31 , , , cord-010119-t1x9gknd 12001 32 2015 2015 CD cord-010119-t1x9gknd 12001 33 . . . cord-010119-t1x9gknd 12002 1 Local local JJ cord-010119-t1x9gknd 12002 2 research research NN cord-010119-t1x9gknd 12002 3 ethics ethic NNS cord-010119-t1x9gknd 12002 4 board board NN cord-010119-t1x9gknd 12002 5 approval approval NN cord-010119-t1x9gknd 12002 6 was be VBD cord-010119-t1x9gknd 12002 7 obtained obtain VBN cord-010119-t1x9gknd 12002 8 . . . cord-010119-t1x9gknd 12003 1 Results/ Results/ . cord-010119-t1x9gknd 12004 1 Finding finding NN cord-010119-t1x9gknd 12004 2 : : : cord-010119-t1x9gknd 12004 3 40 40 CD cord-010119-t1x9gknd 12004 4 patients patient NNS cord-010119-t1x9gknd 12004 5 received receive VBD cord-010119-t1x9gknd 12004 6 IVIG IVIG NNP cord-010119-t1x9gknd 12004 7 for for IN cord-010119-t1x9gknd 12004 8 ITP ITP NNP cord-010119-t1x9gknd 12004 9 at at IN cord-010119-t1x9gknd 12004 10 SMH SMH NNP cord-010119-t1x9gknd 12004 11 over over IN cord-010119-t1x9gknd 12004 12 the the DT cord-010119-t1x9gknd 12004 13 study study NN cord-010119-t1x9gknd 12004 14 period period NN cord-010119-t1x9gknd 12004 15 for for IN cord-010119-t1x9gknd 12004 16 a a DT cord-010119-t1x9gknd 12004 17 total total NN cord-010119-t1x9gknd 12004 18 of of IN cord-010119-t1x9gknd 12004 19 76 76 CD cord-010119-t1x9gknd 12004 20 unique unique JJ cord-010119-t1x9gknd 12004 21 IVIG IVIG NNP cord-010119-t1x9gknd 12004 22 infusions infusion NNS cord-010119-t1x9gknd 12004 23 . . . cord-010119-t1x9gknd 12005 1 The the DT cord-010119-t1x9gknd 12005 2 most most RBS cord-010119-t1x9gknd 12005 3 common common JJ cord-010119-t1x9gknd 12005 4 indications indication NNS cord-010119-t1x9gknd 12005 5 for for IN cord-010119-t1x9gknd 12005 6 IVIG IVIG NNP cord-010119-t1x9gknd 12005 7 within within IN cord-010119-t1x9gknd 12005 8 currently currently RB cord-010119-t1x9gknd 12005 9 accepted accept VBN cord-010119-t1x9gknd 12005 10 guidelines guideline NNS cord-010119-t1x9gknd 12005 11 were be VBD cord-010119-t1x9gknd 12005 12 : : : cord-010119-t1x9gknd 12005 13 active active JJ cord-010119-t1x9gknd 12005 14 bleeding bleeding NN cord-010119-t1x9gknd 12005 15 ( ( -LRB- cord-010119-t1x9gknd 12005 16 13 13 CD cord-010119-t1x9gknd 12005 17 , , , cord-010119-t1x9gknd 12005 18 17 17 CD cord-010119-t1x9gknd 12005 19 % % NN cord-010119-t1x9gknd 12005 20 ) ) -RRB- cord-010119-t1x9gknd 12005 21 , , , cord-010119-t1x9gknd 12005 22 pre pre JJ cord-010119-t1x9gknd 12005 23 - - JJ cord-010119-t1x9gknd 12005 24 operative operative JJ cord-010119-t1x9gknd 12005 25 or or CC cord-010119-t1x9gknd 12005 26 antepartum antepartum JJ cord-010119-t1x9gknd 12005 27 care care NN cord-010119-t1x9gknd 12005 28 ( ( -LRB- cord-010119-t1x9gknd 12005 29 22 22 CD cord-010119-t1x9gknd 12005 30 , , , cord-010119-t1x9gknd 12005 31 29 29 CD cord-010119-t1x9gknd 12005 32 % % NN cord-010119-t1x9gknd 12005 33 ) ) -RRB- cord-010119-t1x9gknd 12005 34 , , , cord-010119-t1x9gknd 12005 35 a a DT cord-010119-t1x9gknd 12005 36 platelet platelet NN cord-010119-t1x9gknd 12005 37 count count NN cord-010119-t1x9gknd 12005 38 of of IN cord-010119-t1x9gknd 12005 39 less less JJR cord-010119-t1x9gknd 12005 40 than than IN cord-010119-t1x9gknd 12005 41 10 10 CD cord-010119-t1x9gknd 12005 42 and and CC cord-010119-t1x9gknd 12005 43 contraindication contraindication NN cord-010119-t1x9gknd 12005 44 to to IN cord-010119-t1x9gknd 12005 45 corticosteroids corticosteroid NNS cord-010119-t1x9gknd 12005 46 ( ( -LRB- cord-010119-t1x9gknd 12005 47 8 8 CD cord-010119-t1x9gknd 12005 48 , , , cord-010119-t1x9gknd 12005 49 11 11 CD cord-010119-t1x9gknd 12005 50 % % NN cord-010119-t1x9gknd 12005 51 ) ) -RRB- cord-010119-t1x9gknd 12005 52 . . . cord-010119-t1x9gknd 12006 1 Additional additional JJ cord-010119-t1x9gknd 12006 2 indications indication NNS cord-010119-t1x9gknd 12006 3 that that WDT cord-010119-t1x9gknd 12006 4 still still RB cord-010119-t1x9gknd 12006 5 fell fall VBD cord-010119-t1x9gknd 12006 6 within within IN cord-010119-t1x9gknd 12006 7 accepted accept VBN cord-010119-t1x9gknd 12006 8 guideline guideline NN cord-010119-t1x9gknd 12006 9 recommendations recommendation NNS cord-010119-t1x9gknd 12006 10 included include VBD cord-010119-t1x9gknd 12006 11 : : : cord-010119-t1x9gknd 12006 12 patients patient NNS cord-010119-t1x9gknd 12006 13 with with IN cord-010119-t1x9gknd 12006 14 arterial arterial JJ cord-010119-t1x9gknd 12006 15 / / SYM cord-010119-t1x9gknd 12006 16 venous venous JJ cord-010119-t1x9gknd 12006 17 thromboembolism thromboembolism NN cord-010119-t1x9gknd 12006 18 or or CC cord-010119-t1x9gknd 12006 19 risk risk NN cord-010119-t1x9gknd 12006 20 thereof thereof IN cord-010119-t1x9gknd 12006 21 requiring require VBG cord-010119-t1x9gknd 12006 22 initiation initiation NN cord-010119-t1x9gknd 12006 23 of of IN cord-010119-t1x9gknd 12006 24 antithrombotic antithrombotic JJ cord-010119-t1x9gknd 12006 25 therapy therapy NN cord-010119-t1x9gknd 12006 26 ; ; : cord-010119-t1x9gknd 12006 27 and and CC cord-010119-t1x9gknd 12006 28 patients patient NNS cord-010119-t1x9gknd 12006 29 requiring require VBG cord-010119-t1x9gknd 12006 30 myelosuppressive myelosuppressive NN cord-010119-t1x9gknd 12006 31 chemotherapy chemotherapy NN cord-010119-t1x9gknd 12006 32 . . . cord-010119-t1x9gknd 12007 1 Indications indication NNS cord-010119-t1x9gknd 12007 2 that that WDT cord-010119-t1x9gknd 12007 3 fell fall VBD cord-010119-t1x9gknd 12007 4 outside outside RB cord-010119-t1x9gknd 12007 5 of of IN cord-010119-t1x9gknd 12007 6 guidelines guideline NNS cord-010119-t1x9gknd 12007 7 included include VBN cord-010119-t1x9gknd 12007 8 : : : cord-010119-t1x9gknd 12007 9 use use NN cord-010119-t1x9gknd 12007 10 of of IN cord-010119-t1x9gknd 12007 11 IVIG IVIG NNP cord-010119-t1x9gknd 12007 12 as as IN cord-010119-t1x9gknd 12007 13 a a DT cord-010119-t1x9gknd 12007 14 diagnostic diagnostic JJ cord-010119-t1x9gknd 12007 15 challenge challenge NN cord-010119-t1x9gknd 12007 16 where where WRB cord-010119-t1x9gknd 12007 17 the the DT cord-010119-t1x9gknd 12007 18 etiology etiology NN cord-010119-t1x9gknd 12007 19 of of IN cord-010119-t1x9gknd 12007 20 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 12007 21 was be VBD cord-010119-t1x9gknd 12007 22 unclear unclear JJ cord-010119-t1x9gknd 12007 23 and and CC cord-010119-t1x9gknd 12007 24 use use VBP cord-010119-t1x9gknd 12007 25 prior prior RB cord-010119-t1x9gknd 12007 26 to to IN cord-010119-t1x9gknd 12007 27 international international JJ cord-010119-t1x9gknd 12007 28 travel travel NN cord-010119-t1x9gknd 12007 29 for for IN cord-010119-t1x9gknd 12007 30 patients patient NNS cord-010119-t1x9gknd 12007 31 with with IN cord-010119-t1x9gknd 12007 32 difficult difficult JJ cord-010119-t1x9gknd 12007 33 - - HYPH cord-010119-t1x9gknd 12007 34 to to TO cord-010119-t1x9gknd 12007 35 - - HYPH cord-010119-t1x9gknd 12007 36 treat treat VB cord-010119-t1x9gknd 12007 37 chronic chronic NN cord-010119-t1x9gknd 12007 38 ITP ITP NNP cord-010119-t1x9gknd 12007 39 despite despite IN cord-010119-t1x9gknd 12007 40 a a DT cord-010119-t1x9gknd 12007 41 platelet platelet NN cord-010119-t1x9gknd 12007 42 count count NN cord-010119-t1x9gknd 12007 43 between between IN cord-010119-t1x9gknd 12007 44 30 30 CD cord-010119-t1x9gknd 12007 45 - - SYM cord-010119-t1x9gknd 12007 46 50 50 CD cord-010119-t1x9gknd 12007 47 x x SYM cord-010119-t1x9gknd 12007 48 109 109 CD cord-010119-t1x9gknd 12007 49 / / SYM cord-010119-t1x9gknd 12007 50 L. L. NNP cord-010119-t1x9gknd 12007 51 6 6 CD cord-010119-t1x9gknd 12007 52 patients patient NNS cord-010119-t1x9gknd 12007 53 received receive VBD cord-010119-t1x9gknd 12007 54 IVIG IVIG NNP cord-010119-t1x9gknd 12007 55 for for IN cord-010119-t1x9gknd 12007 56 a a DT cord-010119-t1x9gknd 12007 57 likely likely JJ cord-010119-t1x9gknd 12007 58 diagnosis diagnosis NN cord-010119-t1x9gknd 12007 59 ITP ITP NNP cord-010119-t1x9gknd 12007 60 while while IN cord-010119-t1x9gknd 12007 61 245A 245a CD cord-010119-t1x9gknd 12007 62 TRANSFUSION transfusion NN cord-010119-t1x9gknd 12007 63 being be VBG cord-010119-t1x9gknd 12007 64 investigated investigate VBN cord-010119-t1x9gknd 12007 65 for for IN cord-010119-t1x9gknd 12007 66 alternative alternative JJ cord-010119-t1x9gknd 12007 67 explanations explanation NNS cord-010119-t1x9gknd 12007 68 for for IN cord-010119-t1x9gknd 12007 69 thrombocytopenia thrombocytopenia NN cord-010119-t1x9gknd 12007 70 . . . cord-010119-t1x9gknd 12008 1 Three three CD cord-010119-t1x9gknd 12008 2 patients patient NNS cord-010119-t1x9gknd 12008 3 were be VBD cord-010119-t1x9gknd 12008 4 refractory refractory JJ cord-010119-t1x9gknd 12008 5 to to IN cord-010119-t1x9gknd 12008 6 all all DT cord-010119-t1x9gknd 12008 7 other other JJ cord-010119-t1x9gknd 12008 8 therapy therapy NN cord-010119-t1x9gknd 12008 9 for for IN cord-010119-t1x9gknd 12008 10 ITP ITP NNP cord-010119-t1x9gknd 12008 11 and and CC cord-010119-t1x9gknd 12008 12 were be VBD cord-010119-t1x9gknd 12008 13 dependent dependent JJ cord-010119-t1x9gknd 12008 14 on on IN cord-010119-t1x9gknd 12008 15 regular regular JJ cord-010119-t1x9gknd 12008 16 IVIG IVIG NNP cord-010119-t1x9gknd 12008 17 infusions infusion NNS cord-010119-t1x9gknd 12008 18 . . . cord-010119-t1x9gknd 12009 1 18/76 18/76 CD cord-010119-t1x9gknd 12009 2 ( ( -LRB- cord-010119-t1x9gknd 12009 3 24 24 CD cord-010119-t1x9gknd 12009 4 % % NN cord-010119-t1x9gknd 12009 5 ) ) -RRB- cord-010119-t1x9gknd 12009 6 of of IN cord-010119-t1x9gknd 12009 7 infusions infusion NNS cord-010119-t1x9gknd 12009 8 consisted consist VBN cord-010119-t1x9gknd 12009 9 of of IN cord-010119-t1x9gknd 12009 10 2g 2g CD cord-010119-t1x9gknd 12009 11 / / SYM cord-010119-t1x9gknd 12009 12 kg kg NNS cord-010119-t1x9gknd 12009 13 over over IN cord-010119-t1x9gknd 12009 14 2 2 CD cord-010119-t1x9gknd 12009 15 days day NNS cord-010119-t1x9gknd 12009 16 ; ; : cord-010119-t1x9gknd 12009 17 the the DT cord-010119-t1x9gknd 12009 18 remainder remainder NN cord-010119-t1x9gknd 12009 19 of of IN cord-010119-t1x9gknd 12009 20 infusions infusion NNS cord-010119-t1x9gknd 12009 21 consisted consist VBN cord-010119-t1x9gknd 12009 22 of of IN cord-010119-t1x9gknd 12009 23 1g 1g CD cord-010119-t1x9gknd 12009 24 / / SYM cord-010119-t1x9gknd 12009 25 kg kg NNS cord-010119-t1x9gknd 12009 26 . . . cord-010119-t1x9gknd 12010 1 Of of IN cord-010119-t1x9gknd 12010 2 those those DT cord-010119-t1x9gknd 12010 3 who who WP cord-010119-t1x9gknd 12010 4 received receive VBD cord-010119-t1x9gknd 12010 5 2g 2g CD cord-010119-t1x9gknd 12010 6 / / SYM cord-010119-t1x9gknd 12010 7 kg,3 kg,3 NNS cord-010119-t1x9gknd 12010 8 of of IN cord-010119-t1x9gknd 12010 9 patients patient NNS cord-010119-t1x9gknd 12010 10 ( ( -LRB- cord-010119-t1x9gknd 12010 11 17 17 CD cord-010119-t1x9gknd 12010 12 % % NN cord-010119-t1x9gknd 12010 13 ) ) -RRB- cord-010119-t1x9gknd 12010 14 had have VBD cord-010119-t1x9gknd 12010 15 evidence evidence NN cord-010119-t1x9gknd 12010 16 of of IN cord-010119-t1x9gknd 12010 17 partial partial JJ cord-010119-t1x9gknd 12010 18 remission remission NN cord-010119-t1x9gknd 12010 19 after after IN cord-010119-t1x9gknd 12010 20 a a DT cord-010119-t1x9gknd 12010 21 first first JJ cord-010119-t1x9gknd 12010 22 1g 1g CD cord-010119-t1x9gknd 12010 23 / / SYM cord-010119-t1x9gknd 12010 24 kg kg NN cord-010119-t1x9gknd 12010 25 dose dose NN cord-010119-t1x9gknd 12010 26 . . . cord-010119-t1x9gknd 12011 1 IVIG IVIG NNP cord-010119-t1x9gknd 12011 2 was be VBD cord-010119-t1x9gknd 12011 3 generally generally RB cord-010119-t1x9gknd 12011 4 well well RB cord-010119-t1x9gknd 12011 5 tolerated tolerate VBN cord-010119-t1x9gknd 12011 6 and and CC cord-010119-t1x9gknd 12011 7 infusion infusion NN cord-010119-t1x9gknd 12011 8 reactions reaction NNS cord-010119-t1x9gknd 12011 9 were be VBD cord-010119-t1x9gknd 12011 10 mitigated mitigate VBN cord-010119-t1x9gknd 12011 11 with with IN cord-010119-t1x9gknd 12011 12 use use NN cord-010119-t1x9gknd 12011 13 of of IN cord-010119-t1x9gknd 12011 14 corticosteroids corticosteroid NNS cord-010119-t1x9gknd 12011 15 , , , cord-010119-t1x9gknd 12011 16 antipyretics antipyretic NNS cord-010119-t1x9gknd 12011 17 and/or and/or CC cord-010119-t1x9gknd 12011 18 antihistamines antihistamine NNS cord-010119-t1x9gknd 12011 19 . . . cord-010119-t1x9gknd 12012 1 Conclusion conclusion NN cord-010119-t1x9gknd 12012 2 : : : cord-010119-t1x9gknd 12012 3 We -PRON- PRP cord-010119-t1x9gknd 12012 4 found find VBD cord-010119-t1x9gknd 12012 5 , , , cord-010119-t1x9gknd 12012 6 at at IN cord-010119-t1x9gknd 12012 7 our -PRON- PRP$ cord-010119-t1x9gknd 12012 8 institution institution NN cord-010119-t1x9gknd 12012 9 , , , cord-010119-t1x9gknd 12012 10 that that DT cord-010119-t1x9gknd 12012 11 use use NN cord-010119-t1x9gknd 12012 12 of of IN cord-010119-t1x9gknd 12012 13 IVIG IVIG NNP cord-010119-t1x9gknd 12012 14 for for IN cord-010119-t1x9gknd 12012 15 ITP ITP NNP cord-010119-t1x9gknd 12012 16 was be VBD cord-010119-t1x9gknd 12012 17 generally generally RB cord-010119-t1x9gknd 12012 18 appropriate appropriate JJ cord-010119-t1x9gknd 12012 19 and and CC cord-010119-t1x9gknd 12012 20 carefully carefully RB cord-010119-t1x9gknd 12012 21 considered consider VBN cord-010119-t1x9gknd 12012 22 even even RB cord-010119-t1x9gknd 12012 23 in in IN cord-010119-t1x9gknd 12012 24 cases case NNS cord-010119-t1x9gknd 12012 25 that that WDT cord-010119-t1x9gknd 12012 26 did do VBD cord-010119-t1x9gknd 12012 27 not not RB cord-010119-t1x9gknd 12012 28 meet meet VB cord-010119-t1x9gknd 12012 29 current current JJ cord-010119-t1x9gknd 12012 30 guideline guideline NN cord-010119-t1x9gknd 12012 31 recommendations recommendation NNS cord-010119-t1x9gknd 12012 32 . . . cord-010119-t1x9gknd 12013 1 We -PRON- PRP cord-010119-t1x9gknd 12013 2 believe believe VBP cord-010119-t1x9gknd 12013 3 that that IN cord-010119-t1x9gknd 12013 4 IVIG IVIG NNP cord-010119-t1x9gknd 12013 5 remains remain VBZ cord-010119-t1x9gknd 12013 6 an an DT cord-010119-t1x9gknd 12013 7 important important JJ cord-010119-t1x9gknd 12013 8 treatment treatment NN cord-010119-t1x9gknd 12013 9 for for IN cord-010119-t1x9gknd 12013 10 ITP ITP NNP cord-010119-t1x9gknd 12013 11 particularly particularly RB cord-010119-t1x9gknd 12013 12 in in IN cord-010119-t1x9gknd 12013 13 the the DT cord-010119-t1x9gknd 12013 14 aging age VBG cord-010119-t1x9gknd 12013 15 population population NN cord-010119-t1x9gknd 12013 16 where where WRB cord-010119-t1x9gknd 12013 17 prevalence prevalence NN cord-010119-t1x9gknd 12013 18 of of IN cord-010119-t1x9gknd 12013 19 conditions condition NNS cord-010119-t1x9gknd 12013 20 complicating complicate VBG cord-010119-t1x9gknd 12013 21 bleeding bleed VBG cord-010119-t1x9gknd 12013 22 risk risk NN cord-010119-t1x9gknd 12013 23 is be VBZ cord-010119-t1x9gknd 12013 24 increasing increase VBG cord-010119-t1x9gknd 12013 25 . . . cord-010119-t1x9gknd 12014 1 Detailed detailed JJ cord-010119-t1x9gknd 12014 2 utilization/ utilization/ JJ cord-010119-t1x9gknd 12014 3 knowledge knowledge NN cord-010119-t1x9gknd 12014 4 data datum NNS cord-010119-t1x9gknd 12014 5 inquiries inquiry NNS cord-010119-t1x9gknd 12014 6 are be VBP cord-010119-t1x9gknd 12014 7 required require VBN cord-010119-t1x9gknd 12014 8 to to TO cord-010119-t1x9gknd 12014 9 develop develop VB cord-010119-t1x9gknd 12014 10 tools tool NNS cord-010119-t1x9gknd 12014 11 and and CC cord-010119-t1x9gknd 12014 12 policies policy NNS cord-010119-t1x9gknd 12014 13 to to TO cord-010119-t1x9gknd 12014 14 enhance enhance VB cord-010119-t1x9gknd 12014 15 appropriate appropriate JJ cord-010119-t1x9gknd 12014 16 IVIG IVIG NNP cord-010119-t1x9gknd 12014 17 use use NN cord-010119-t1x9gknd 12014 18 in in IN cord-010119-t1x9gknd 12014 19 multiple multiple JJ cord-010119-t1x9gknd 12014 20 settings setting NNS cord-010119-t1x9gknd 12014 21 . . . cord-010119-t1x9gknd 12015 1 We -PRON- PRP cord-010119-t1x9gknd 12015 2 believe believe VBP cord-010119-t1x9gknd 12015 3 that that IN cord-010119-t1x9gknd 12015 4 there there EX cord-010119-t1x9gknd 12015 5 is be VBZ cord-010119-t1x9gknd 12015 6 an an DT cord-010119-t1x9gknd 12015 7 opportunity opportunity NN cord-010119-t1x9gknd 12015 8 to to TO cord-010119-t1x9gknd 12015 9 promote promote VB cord-010119-t1x9gknd 12015 10 administration administration NN cord-010119-t1x9gknd 12015 11 of of IN cord-010119-t1x9gknd 12015 12 a a DT cord-010119-t1x9gknd 12015 13 single single JJ cord-010119-t1x9gknd 12015 14 1g 1g CD cord-010119-t1x9gknd 12015 15 / / SYM cord-010119-t1x9gknd 12015 16 kg kg NNS cord-010119-t1x9gknd 12015 17 dose dose NN cord-010119-t1x9gknd 12015 18 to to TO cord-010119-t1x9gknd 12015 19 minimize minimize VB cord-010119-t1x9gknd 12015 20 unnecessary unnecessary JJ cord-010119-t1x9gknd 12015 21 utilization utilization NN cord-010119-t1x9gknd 12015 22 of of IN cord-010119-t1x9gknd 12015 23 IVIG IVIG NNP cord-010119-t1x9gknd 12015 24 amongst amongst IN cord-010119-t1x9gknd 12015 25 hematologists hematologist NNS cord-010119-t1x9gknd 12015 26 who who WP cord-010119-t1x9gknd 12015 27 manage manage VBP cord-010119-t1x9gknd 12015 28 ITP ITP NNP cord-010119-t1x9gknd 12015 29 . . . cord-010119-t1x9gknd 12016 1 A a DT cord-010119-t1x9gknd 12016 2 Process process NN cord-010119-t1x9gknd 12016 3 for for IN cord-010119-t1x9gknd 12016 4 Improving improve VBG cord-010119-t1x9gknd 12016 5 Crossmatch Crossmatch NNP cord-010119-t1x9gknd 12016 6 Bench Bench NNP cord-010119-t1x9gknd 12016 7 Ergonomics Ergonomics NNP cord-010119-t1x9gknd 12016 8 Janet Janet NNP cord-010119-t1x9gknd 12016 9 Dornfeld Dornfeld NNP cord-010119-t1x9gknd 12017 1 * * NFP cord-010119-t1x9gknd 12017 2 , , , cord-010119-t1x9gknd 12017 3 Sheng Sheng NNP cord-010119-t1x9gknd 12017 4 - - HYPH cord-010119-t1x9gknd 12017 5 Chung Chung NNP cord-010119-t1x9gknd 12017 6 Cheng Cheng NNP cord-010119-t1x9gknd 12017 7 , , , cord-010119-t1x9gknd 12017 8 Ann Ann NNP cord-010119-t1x9gknd 12017 9 Eggebrecht Eggebrecht NNP cord-010119-t1x9gknd 12017 10 , , , cord-010119-t1x9gknd 12017 11 Beth Beth NNP cord-010119-t1x9gknd 12017 12 Greer Greer NNP cord-010119-t1x9gknd 12017 13 , , , cord-010119-t1x9gknd 12017 14 SavannahSue SavannahSue NNP cord-010119-t1x9gknd 12017 15 Rondeau Rondeau NNP cord-010119-t1x9gknd 12017 16 , , , cord-010119-t1x9gknd 12017 17 Brian Brian NNP cord-010119-t1x9gknd 12017 18 Rognholt Rognholt NNP cord-010119-t1x9gknd 12017 19 and and CC cord-010119-t1x9gknd 12017 20 Beth Beth NNP cord-010119-t1x9gknd 12017 21 Taylor Taylor NNP cord-010119-t1x9gknd 12017 22 . . . cord-010119-t1x9gknd 12018 1 Mayo Mayo NNP cord-010119-t1x9gknd 12018 2 Clinic Clinic NNP cord-010119-t1x9gknd 12018 3 Background Background NNP cord-010119-t1x9gknd 12018 4 / / SYM cord-010119-t1x9gknd 12018 5 Case Case NNP cord-010119-t1x9gknd 12018 6 Studies Studies NNPS cord-010119-t1x9gknd 12019 1 : : : cord-010119-t1x9gknd 12019 2 A a DT cord-010119-t1x9gknd 12019 3 mission mission NN cord-010119-t1x9gknd 12019 4 of of IN cord-010119-t1x9gknd 12019 5 our -PRON- PRP$ cord-010119-t1x9gknd 12019 6 institution institution NN cord-010119-t1x9gknd 12019 7 is be VBZ cord-010119-t1x9gknd 12019 8 to to TO cord-010119-t1x9gknd 12019 9 reduce reduce VB cord-010119-t1x9gknd 12019 10 the the DT cord-010119-t1x9gknd 12019 11 risk risk NN cord-010119-t1x9gknd 12019 12 of of IN cord-010119-t1x9gknd 12019 13 work work NN cord-010119-t1x9gknd 12019 14 - - HYPH cord-010119-t1x9gknd 12019 15 related relate VBN cord-010119-t1x9gknd 12019 16 injuries injury NNS cord-010119-t1x9gknd 12019 17 . . . cord-010119-t1x9gknd 12020 1 Accordingly accordingly RB cord-010119-t1x9gknd 12020 2 , , , cord-010119-t1x9gknd 12020 3 each each DT cord-010119-t1x9gknd 12020 4 year year NN cord-010119-t1x9gknd 12020 5 an an DT cord-010119-t1x9gknd 12020 6 ergonomic ergonomic JJ cord-010119-t1x9gknd 12020 7 survey survey NN cord-010119-t1x9gknd 12020 8 is be VBZ cord-010119-t1x9gknd 12020 9 undertaken undertake VBN cord-010119-t1x9gknd 12020 10 as as IN cord-010119-t1x9gknd 12020 11 a a DT cord-010119-t1x9gknd 12020 12 component component NN cord-010119-t1x9gknd 12020 13 of of IN cord-010119-t1x9gknd 12020 14 a a DT cord-010119-t1x9gknd 12020 15 general general JJ cord-010119-t1x9gknd 12020 16 Department Department NNP cord-010119-t1x9gknd 12020 17 of of IN cord-010119-t1x9gknd 12020 18 Laboratory Laboratory NNP cord-010119-t1x9gknd 12020 19 Medicine Medicine NNP cord-010119-t1x9gknd 12020 20 and and CC cord-010119-t1x9gknd 12020 21 Pathology Pathology NNP cord-010119-t1x9gknd 12020 22 safety safety NN cord-010119-t1x9gknd 12020 23 audit audit NN cord-010119-t1x9gknd 12020 24 . . . cord-010119-t1x9gknd 12021 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12021 2 2016 2016 CD cord-010119-t1x9gknd 12021 3 survey survey NN cord-010119-t1x9gknd 12021 4 identified identify VBD cord-010119-t1x9gknd 12021 5 potential potential JJ cord-010119-t1x9gknd 12021 6 musculoskeletal musculoskeletal JJ cord-010119-t1x9gknd 12021 7 risks risk NNS cord-010119-t1x9gknd 12021 8 that that WDT cord-010119-t1x9gknd 12021 9 suggested suggest VBD cord-010119-t1x9gknd 12021 10 a a DT cord-010119-t1x9gknd 12021 11 redesign redesign NN cord-010119-t1x9gknd 12021 12 of of IN cord-010119-t1x9gknd 12021 13 our -PRON- PRP$ cord-010119-t1x9gknd 12021 14 crossmatch crossmatch NN cord-010119-t1x9gknd 12021 15 benches bench NNS cord-010119-t1x9gknd 12021 16 . . . cord-010119-t1x9gknd 12022 1 Study Study NNP cord-010119-t1x9gknd 12022 2 Design Design NNP cord-010119-t1x9gknd 12022 3 / / SYM cord-010119-t1x9gknd 12022 4 Methods method NNS cord-010119-t1x9gknd 12022 5 : : : cord-010119-t1x9gknd 12022 6 A a DT cord-010119-t1x9gknd 12022 7 seven seven CD cord-010119-t1x9gknd 12022 8 item item NN cord-010119-t1x9gknd 12022 9 ergonomics ergonomic NNS cord-010119-t1x9gknd 12022 10 survey survey NN cord-010119-t1x9gknd 12022 11 of of IN cord-010119-t1x9gknd 12022 12 the the DT cord-010119-t1x9gknd 12022 13 working work VBG cord-010119-t1x9gknd 12022 14 environment environment NN cord-010119-t1x9gknd 12022 15 was be VBD cord-010119-t1x9gknd 12022 16 sent send VBN cord-010119-t1x9gknd 12022 17 to to IN cord-010119-t1x9gknd 12022 18 32 32 CD cord-010119-t1x9gknd 12022 19 staff staff NN cord-010119-t1x9gknd 12022 20 members member NNS cord-010119-t1x9gknd 12022 21 in in IN cord-010119-t1x9gknd 12022 22 early early JJ cord-010119-t1x9gknd 12022 23 February February NNP cord-010119-t1x9gknd 12022 24 of of IN cord-010119-t1x9gknd 12022 25 2017 2017 CD cord-010119-t1x9gknd 12022 26 . . . cord-010119-t1x9gknd 12023 1 Twenty twenty CD cord-010119-t1x9gknd 12023 2 - - HYPH cord-010119-t1x9gknd 12023 3 two two CD cord-010119-t1x9gknd 12023 4 technologists technologist NNS cord-010119-t1x9gknd 12023 5 responded respond VBD cord-010119-t1x9gknd 12023 6 for for IN cord-010119-t1x9gknd 12023 7 a a DT cord-010119-t1x9gknd 12023 8 69 69 CD cord-010119-t1x9gknd 12023 9 % % NN cord-010119-t1x9gknd 12023 10 response response NN cord-010119-t1x9gknd 12023 11 rate rate NN cord-010119-t1x9gknd 12023 12 . . . cord-010119-t1x9gknd 12024 1 The the DT cord-010119-t1x9gknd 12024 2 below below JJ cord-010119-t1x9gknd 12024 3 table table NN cord-010119-t1x9gknd 12024 4 below below IN cord-010119-t1x9gknd 12024 5 reports report VBZ cord-010119-t1x9gknd 12024 6 the the DT cord-010119-t1x9gknd 12024 7 survey survey NN cord-010119-t1x9gknd 12024 8 items item NNS cord-010119-t1x9gknd 12024 9 and and CC cord-010119-t1x9gknd 12024 10 responses response NNS cord-010119-t1x9gknd 12024 11 . . . cord-010119-t1x9gknd 12025 1 Results result NNS cord-010119-t1x9gknd 12025 2 / / SYM cord-010119-t1x9gknd 12025 3 Findings finding NNS cord-010119-t1x9gknd 12025 4 : : : cord-010119-t1x9gknd 12026 1 The the DT cord-010119-t1x9gknd 12026 2 most most RBS cord-010119-t1x9gknd 12026 3 problematic problematic JJ cord-010119-t1x9gknd 12026 4 area area NN cord-010119-t1x9gknd 12026 5 was be VBD cord-010119-t1x9gknd 12026 6 the the DT cord-010119-t1x9gknd 12026 7 available available JJ cord-010119-t1x9gknd 12026 8 workspace workspace NN cord-010119-t1x9gknd 12026 9 . . . cord-010119-t1x9gknd 12027 1 Of of IN cord-010119-t1x9gknd 12027 2 the the DT cord-010119-t1x9gknd 12027 3 respondents respondent NNS cord-010119-t1x9gknd 12027 4 , , , cord-010119-t1x9gknd 12027 5 81 81 CD cord-010119-t1x9gknd 12027 6 % % NN cord-010119-t1x9gknd 12027 7 indicated indicate VBD cord-010119-t1x9gknd 12027 8 that that IN cord-010119-t1x9gknd 12027 9 workspace workspace NN cord-010119-t1x9gknd 12027 10 size size NN cord-010119-t1x9gknd 12027 11 was be VBD cord-010119-t1x9gknd 12027 12 insufficient insufficient JJ cord-010119-t1x9gknd 12027 13 and and CC cord-010119-t1x9gknd 12027 14 71 71 CD cord-010119-t1x9gknd 12027 15 % % NN cord-010119-t1x9gknd 12027 16 that that IN cord-010119-t1x9gknd 12027 17 the the DT cord-010119-t1x9gknd 12027 18 chairs chair NNS cord-010119-t1x9gknd 12027 19 at at IN cord-010119-t1x9gknd 12027 20 the the DT cord-010119-t1x9gknd 12027 21 fixed fix VBN cord-010119-t1x9gknd 12027 22 height height NN cord-010119-t1x9gknd 12027 23 benches bench NNS cord-010119-t1x9gknd 12027 24 were be VBD cord-010119-t1x9gknd 12027 25 problematic problematic JJ cord-010119-t1x9gknd 12027 26 . . . cord-010119-t1x9gknd 12028 1 Problems problem NNS cord-010119-t1x9gknd 12028 2 noted note VBN cord-010119-t1x9gknd 12028 3 were be VBD cord-010119-t1x9gknd 12028 4 difficulty difficulty JJ cord-010119-t1x9gknd 12028 5 with with IN cord-010119-t1x9gknd 12028 6 climbing climb VBG cord-010119-t1x9gknd 12028 7 up up RP cord-010119-t1x9gknd 12028 8 into into IN cord-010119-t1x9gknd 12028 9 a a DT cord-010119-t1x9gknd 12028 10 chair chair NN cord-010119-t1x9gknd 12028 11 and and CC cord-010119-t1x9gknd 12028 12 backing back VBG cord-010119-t1x9gknd 12028 13 down down RP cord-010119-t1x9gknd 12028 14 and and CC cord-010119-t1x9gknd 12028 15 with with IN cord-010119-t1x9gknd 12028 16 the the DT cord-010119-t1x9gknd 12028 17 chairs chair NNS cord-010119-t1x9gknd 12028 18 holding hold VBG cord-010119-t1x9gknd 12028 19 the the DT cord-010119-t1x9gknd 12028 20 chosen choose VBN cord-010119-t1x9gknd 12028 21 height height NN cord-010119-t1x9gknd 12028 22 . . . cord-010119-t1x9gknd 12029 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12029 2 laboratory laboratory NN cord-010119-t1x9gknd 12029 3 Lean Lean NNP cord-010119-t1x9gknd 12029 4 Team Team NNP cord-010119-t1x9gknd 12029 5 Operational Operational NNP cord-010119-t1x9gknd 12029 6 Support Support NNP cord-010119-t1x9gknd 12029 7 Group Group NNP cord-010119-t1x9gknd 12029 8 was be VBD cord-010119-t1x9gknd 12029 9 tasked task VBN cord-010119-t1x9gknd 12029 10 to to TO cord-010119-t1x9gknd 12029 11 aid aid VB cord-010119-t1x9gknd 12029 12 with with IN cord-010119-t1x9gknd 12029 13 the the DT cord-010119-t1x9gknd 12029 14 bench bench NN cord-010119-t1x9gknd 12029 15 redesign redesign NN cord-010119-t1x9gknd 12029 16 and and CC cord-010119-t1x9gknd 12029 17 to to TO cord-010119-t1x9gknd 12029 18 choose choose VB cord-010119-t1x9gknd 12029 19 products product NNS cord-010119-t1x9gknd 12029 20 for for IN cord-010119-t1x9gknd 12029 21 improving improve VBG cord-010119-t1x9gknd 12029 22 the the DT cord-010119-t1x9gknd 12029 23 workspace workspace NN cord-010119-t1x9gknd 12029 24 . . . cord-010119-t1x9gknd 12030 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12030 2 goals goal NNS cord-010119-t1x9gknd 12030 3 were be VBD cord-010119-t1x9gknd 12030 4 to to TO cord-010119-t1x9gknd 12030 5 design design VB cord-010119-t1x9gknd 12030 6 a a DT cord-010119-t1x9gknd 12030 7 layout layout NN cord-010119-t1x9gknd 12030 8 to to TO cord-010119-t1x9gknd 12030 9 streamline streamline VB cord-010119-t1x9gknd 12030 10 testing testing NN cord-010119-t1x9gknd 12030 11 workflow workflow NN cord-010119-t1x9gknd 12030 12 and and CC cord-010119-t1x9gknd 12030 13 better well RBR cord-010119-t1x9gknd 12030 14 utilize utilize VB cord-010119-t1x9gknd 12030 15 lab lab NN cord-010119-t1x9gknd 12030 16 space space NN cord-010119-t1x9gknd 12030 17 , , , cord-010119-t1x9gknd 12030 18 including include VBG cord-010119-t1x9gknd 12030 19 our -PRON- PRP$ cord-010119-t1x9gknd 12030 20 plasma plasma NN cord-010119-t1x9gknd 12030 21 thawing thawing NN cord-010119-t1x9gknd 12030 22 and and CC cord-010119-t1x9gknd 12030 23 sink sink NN cord-010119-t1x9gknd 12030 24 space space NN cord-010119-t1x9gknd 12030 25 , , , cord-010119-t1x9gknd 12030 26 eliminating eliminate VBG cord-010119-t1x9gknd 12030 27 dead dead JJ cord-010119-t1x9gknd 12030 28 space space NN cord-010119-t1x9gknd 12030 29 . . . cord-010119-t1x9gknd 12031 1 The the DT cord-010119-t1x9gknd 12031 2 configuration configuration NN cord-010119-t1x9gknd 12031 3 of of IN cord-010119-t1x9gknd 12031 4 the the DT cord-010119-t1x9gknd 12031 5 new new JJ cord-010119-t1x9gknd 12031 6 workspace workspace NN cord-010119-t1x9gknd 12031 7 was be VBD cord-010119-t1x9gknd 12031 8 guided guide VBN cord-010119-t1x9gknd 12031 9 by by IN cord-010119-t1x9gknd 12031 10 the the DT cord-010119-t1x9gknd 12031 11 survey survey NN cord-010119-t1x9gknd 12031 12 findings finding NNS cord-010119-t1x9gknd 12031 13 . . . cord-010119-t1x9gknd 12032 1 Adjustable adjustable JJ cord-010119-t1x9gknd 12032 2 height height NN cord-010119-t1x9gknd 12032 3 workstations workstation NNS cord-010119-t1x9gknd 12032 4 were be VBD cord-010119-t1x9gknd 12032 5 recommended recommend VBN cord-010119-t1x9gknd 12032 6 to to TO cord-010119-t1x9gknd 12032 7 replace replace VB cord-010119-t1x9gknd 12032 8 our -PRON- PRP$ cord-010119-t1x9gknd 12032 9 fixed fixed JJ cord-010119-t1x9gknd 12032 10 height height NN cord-010119-t1x9gknd 12032 11 bench bench NN cord-010119-t1x9gknd 12032 12 . . . cord-010119-t1x9gknd 12033 1 We -PRON- PRP cord-010119-t1x9gknd 12033 2 worked work VBD cord-010119-t1x9gknd 12033 3 with with IN cord-010119-t1x9gknd 12033 4 our -PRON- PRP$ cord-010119-t1x9gknd 12033 5 facilities facility NNS cord-010119-t1x9gknd 12033 6 design design NN cord-010119-t1x9gknd 12033 7 contactor contactor NN cord-010119-t1x9gknd 12033 8 to to TO cord-010119-t1x9gknd 12033 9 purchase purchase VB cord-010119-t1x9gknd 12033 10 adjustable adjustable JJ cord-010119-t1x9gknd 12033 11 benches bench NNS cord-010119-t1x9gknd 12033 12 and and CC cord-010119-t1x9gknd 12033 13 plan plan NN cord-010119-t1x9gknd 12033 14 add add VB cord-010119-t1x9gknd 12033 15 - - HYPH cord-010119-t1x9gknd 12033 16 on on RP cord-010119-t1x9gknd 12033 17 cabinet cabinet NN cord-010119-t1x9gknd 12033 18 shop shop NN cord-010119-t1x9gknd 12033 19 work work NN cord-010119-t1x9gknd 12033 20 . . . cord-010119-t1x9gknd 12034 1 The the DT cord-010119-t1x9gknd 12034 2 benches bench NNS cord-010119-t1x9gknd 12034 3 were be VBD cord-010119-t1x9gknd 12034 4 assembled assemble VBN cord-010119-t1x9gknd 12034 5 off off RP cord-010119-t1x9gknd 12034 6 site site NN cord-010119-t1x9gknd 12034 7 , , , cord-010119-t1x9gknd 12034 8 which which WDT cord-010119-t1x9gknd 12034 9 allowed allow VBD cord-010119-t1x9gknd 12034 10 a a DT cord-010119-t1x9gknd 12034 11 bench bench NN cord-010119-t1x9gknd 12034 12 top top JJ cord-010119-t1x9gknd 12034 13 layout layout NN cord-010119-t1x9gknd 12034 14 to to TO cord-010119-t1x9gknd 12034 15 be be VB cord-010119-t1x9gknd 12034 16 determined determine VBN cord-010119-t1x9gknd 12034 17 and and CC cord-010119-t1x9gknd 12034 18 installation installation NN cord-010119-t1x9gknd 12034 19 of of IN cord-010119-t1x9gknd 12034 20 cabinet cabinet NN cord-010119-t1x9gknd 12034 21 shop shop NN cord-010119-t1x9gknd 12034 22 add add NN cord-010119-t1x9gknd 12034 23 - - HYPH cord-010119-t1x9gknd 12034 24 ons on NNS cord-010119-t1x9gknd 12034 25 of of IN cord-010119-t1x9gknd 12034 26 a a DT cord-010119-t1x9gknd 12034 27 drawer drawer NN cord-010119-t1x9gknd 12034 28 for for IN cord-010119-t1x9gknd 12034 29 supplies supply NNS cord-010119-t1x9gknd 12034 30 and and CC cord-010119-t1x9gknd 12034 31 a a DT cord-010119-t1x9gknd 12034 32 pull pull NN cord-010119-t1x9gknd 12034 33 out out RP cord-010119-t1x9gknd 12034 34 breadboard breadboard NN cord-010119-t1x9gknd 12034 35 as as IN cord-010119-t1x9gknd 12034 36 a a DT cord-010119-t1x9gknd 12034 37 writing writing NN cord-010119-t1x9gknd 12034 38 surface surface NN cord-010119-t1x9gknd 12034 39 . . . cord-010119-t1x9gknd 12035 1 The the DT cord-010119-t1x9gknd 12035 2 opportunity opportunity NN cord-010119-t1x9gknd 12035 3 to to TO cord-010119-t1x9gknd 12035 4 assemble assemble VB cord-010119-t1x9gknd 12035 5 off off RP cord-010119-t1x9gknd 12035 6 site site NN cord-010119-t1x9gknd 12035 7 streamlined streamline VBN cord-010119-t1x9gknd 12035 8 the the DT cord-010119-t1x9gknd 12035 9 process process NN cord-010119-t1x9gknd 12035 10 of of IN cord-010119-t1x9gknd 12035 11 installation installation NN cord-010119-t1x9gknd 12035 12 , , , cord-010119-t1x9gknd 12035 13 resulting result VBG cord-010119-t1x9gknd 12035 14 in in IN cord-010119-t1x9gknd 12035 15 minimal minimal JJ cord-010119-t1x9gknd 12035 16 disruption disruption NN cord-010119-t1x9gknd 12035 17 of of IN cord-010119-t1x9gknd 12035 18 testing testing NN cord-010119-t1x9gknd 12035 19 . . . cord-010119-t1x9gknd 12036 1 Conclusion conclusion NN cord-010119-t1x9gknd 12036 2 : : : cord-010119-t1x9gknd 12037 1 The the DT cord-010119-t1x9gknd 12037 2 survey survey NN cord-010119-t1x9gknd 12037 3 was be VBD cord-010119-t1x9gknd 12037 4 effective effective JJ cord-010119-t1x9gknd 12037 5 in in IN cord-010119-t1x9gknd 12037 6 identifying identify VBG cord-010119-t1x9gknd 12037 7 working work VBG cord-010119-t1x9gknd 12037 8 areas area NNS cord-010119-t1x9gknd 12037 9 for for IN cord-010119-t1x9gknd 12037 10 improvement improvement NN cord-010119-t1x9gknd 12037 11 . . . cord-010119-t1x9gknd 12038 1 Employee employee NN cord-010119-t1x9gknd 12038 2 comments comment NNS cord-010119-t1x9gknd 12038 3 have have VBP cord-010119-t1x9gknd 12038 4 been be VBN cord-010119-t1x9gknd 12038 5 positive positive JJ cord-010119-t1x9gknd 12038 6 for for IN cord-010119-t1x9gknd 12038 7 the the DT cord-010119-t1x9gknd 12038 8 new new JJ cord-010119-t1x9gknd 12038 9 workstations workstation NNS cord-010119-t1x9gknd 12038 10 . . . cord-010119-t1x9gknd 12039 1 An an DT cord-010119-t1x9gknd 12039 2 effectiveness effectiveness NN cord-010119-t1x9gknd 12039 3 assessment assessment NN cord-010119-t1x9gknd 12039 4 will will MD cord-010119-t1x9gknd 12039 5 follow follow VB cord-010119-t1x9gknd 12039 6 , , , cord-010119-t1x9gknd 12039 7 using use VBG cord-010119-t1x9gknd 12039 8 the the DT cord-010119-t1x9gknd 12039 9 original original JJ cord-010119-t1x9gknd 12039 10 survey survey NN cord-010119-t1x9gknd 12039 11 , , , cord-010119-t1x9gknd 12039 12 to to TO cord-010119-t1x9gknd 12039 13 assess assess VB cord-010119-t1x9gknd 12039 14 the the DT cord-010119-t1x9gknd 12039 15 success success NN cord-010119-t1x9gknd 12039 16 of of IN cord-010119-t1x9gknd 12039 17 the the DT cord-010119-t1x9gknd 12039 18 project project NN cord-010119-t1x9gknd 12039 19 . . . cord-010119-t1x9gknd 12040 1 A a DT cord-010119-t1x9gknd 12040 2 Retrospective Retrospective NNP cord-010119-t1x9gknd 12040 3 Study Study NNP cord-010119-t1x9gknd 12040 4 of of IN cord-010119-t1x9gknd 12040 5 Emergency Emergency NNP cord-010119-t1x9gknd 12040 6 Department Department NNP cord-010119-t1x9gknd 12040 7 Initiated Initiated NNP cord-010119-t1x9gknd 12040 8 Type Type NNP cord-010119-t1x9gknd 12040 9 and and CC cord-010119-t1x9gknd 12040 10 Screen Screen NNP cord-010119-t1x9gknd 12040 11 Testing testing NN cord-010119-t1x9gknd 12040 12 : : : cord-010119-t1x9gknd 12041 1 Were be VBD cord-010119-t1x9gknd 12041 2 Patients patient NNS cord-010119-t1x9gknd 12041 3 Transfused transfuse VBN cord-010119-t1x9gknd 12041 4 after after IN cord-010119-t1x9gknd 12041 5 Testing testing NN cord-010119-t1x9gknd 12041 6 ? ? . cord-010119-t1x9gknd 12042 1 Sandra Sandra NNP cord-010119-t1x9gknd 12042 2 Lamm Lamm NNP cord-010119-t1x9gknd 12042 3 * * NFP cord-010119-t1x9gknd 12042 4 1 1 CD cord-010119-t1x9gknd 12042 5 , , , cord-010119-t1x9gknd 12042 6 Neil Neil NNP cord-010119-t1x9gknd 12042 7 Bangs Bangs NNP cord-010119-t1x9gknd 12042 8 1 1 CD cord-010119-t1x9gknd 12042 9 and and CC cord-010119-t1x9gknd 12042 10 Kimberly Kimberly NNP cord-010119-t1x9gknd 12042 11 Sanford Sanford NNP cord-010119-t1x9gknd 12042 12 2 2 CD cord-010119-t1x9gknd 12042 13 . . . cord-010119-t1x9gknd 12043 1 1 1 CD cord-010119-t1x9gknd 12043 2 VCU VCU NNP cord-010119-t1x9gknd 12043 3 Health Health NNP cord-010119-t1x9gknd 12043 4 System System NNP cord-010119-t1x9gknd 12043 5 , , , cord-010119-t1x9gknd 12043 6 2 2 CD cord-010119-t1x9gknd 12043 7 Virginia Virginia NNP cord-010119-t1x9gknd 12043 8 Commonwealth Commonwealth NNP cord-010119-t1x9gknd 12043 9 University University NNP cord-010119-t1x9gknd 12043 10 Background Background NNP cord-010119-t1x9gknd 12043 11 / / SYM cord-010119-t1x9gknd 12043 12 Case Case NNP cord-010119-t1x9gknd 12043 13 Studies Studies NNPS cord-010119-t1x9gknd 12043 14 : : : cord-010119-t1x9gknd 12043 15 Type type NN cord-010119-t1x9gknd 12043 16 and and CC cord-010119-t1x9gknd 12043 17 screen screen NN cord-010119-t1x9gknd 12044 1 ( ( -LRB- cord-010119-t1x9gknd 12044 2 T&S t&s NN cord-010119-t1x9gknd 12044 3 ) ) -RRB- cord-010119-t1x9gknd 12044 4 testing testing NN cord-010119-t1x9gknd 12044 5 is be VBZ cord-010119-t1x9gknd 12044 6 often often RB cord-010119-t1x9gknd 12044 7 ordered order VBN cord-010119-t1x9gknd 12044 8 on on IN cord-010119-t1x9gknd 12044 9 patients patient NNS cord-010119-t1x9gknd 12044 10 presenting present VBG cord-010119-t1x9gknd 12044 11 in in IN cord-010119-t1x9gknd 12044 12 the the DT cord-010119-t1x9gknd 12044 13 Emergency Emergency NNP cord-010119-t1x9gknd 12044 14 Department Department NNP cord-010119-t1x9gknd 12044 15 ( ( -LRB- cord-010119-t1x9gknd 12044 16 ED ED NNP cord-010119-t1x9gknd 12044 17 ) ) -RRB- cord-010119-t1x9gknd 12044 18 . . . cord-010119-t1x9gknd 12045 1 If if IN cord-010119-t1x9gknd 12045 2 the the DT cord-010119-t1x9gknd 12045 3 patient patient NN cord-010119-t1x9gknd 12045 4 does do VBZ cord-010119-t1x9gknd 12045 5 not not RB cord-010119-t1x9gknd 12045 6 have have VB cord-010119-t1x9gknd 12045 7 a a DT cord-010119-t1x9gknd 12045 8 historical historical JJ cord-010119-t1x9gknd 12045 9 type type NN cord-010119-t1x9gknd 12045 10 , , , cord-010119-t1x9gknd 12045 11 a a DT cord-010119-t1x9gknd 12045 12 second second JJ cord-010119-t1x9gknd 12045 13 sample sample NN cord-010119-t1x9gknd 12045 14 is be VBZ cord-010119-t1x9gknd 12045 15 drawn draw VBN cord-010119-t1x9gknd 12045 16 with with IN cord-010119-t1x9gknd 12045 17 an an DT cord-010119-t1x9gknd 12045 18 additional additional JJ cord-010119-t1x9gknd 12045 19 phlebotomy phlebotomy NN cord-010119-t1x9gknd 12045 20 for for IN cord-010119-t1x9gknd 12045 21 type type NN cord-010119-t1x9gknd 12045 22 confirmation confirmation NN cord-010119-t1x9gknd 12045 23 . . . cord-010119-t1x9gknd 12046 1 If if IN cord-010119-t1x9gknd 12046 2 the the DT cord-010119-t1x9gknd 12046 3 patient patient NN cord-010119-t1x9gknd 12046 4 does do VBZ cord-010119-t1x9gknd 12046 5 not not RB cord-010119-t1x9gknd 12046 6 need need VB cord-010119-t1x9gknd 12046 7 a a DT cord-010119-t1x9gknd 12046 8 transfusion transfusion NN cord-010119-t1x9gknd 12046 9 of of IN cord-010119-t1x9gknd 12046 10 red red JJ cord-010119-t1x9gknd 12046 11 blood blood NN cord-010119-t1x9gknd 12046 12 cells cell NNS cord-010119-t1x9gknd 12046 13 ( ( -LRB- cord-010119-t1x9gknd 12046 14 RBCs rbc NNS cord-010119-t1x9gknd 12046 15 ) ) -RRB- cord-010119-t1x9gknd 12046 16 , , , cord-010119-t1x9gknd 12046 17 the the DT cord-010119-t1x9gknd 12046 18 testing testing NN cord-010119-t1x9gknd 12046 19 and and CC cord-010119-t1x9gknd 12046 20 second second JJ cord-010119-t1x9gknd 12046 21 phlebotomy phlebotomy NN cord-010119-t1x9gknd 12046 22 is be VBZ cord-010119-t1x9gknd 12046 23 an an DT cord-010119-t1x9gknd 12046 24 inefficient inefficient JJ cord-010119-t1x9gknd 12046 25 use use NN cord-010119-t1x9gknd 12046 26 of of IN cord-010119-t1x9gknd 12046 27 resources resource NNS cord-010119-t1x9gknd 12046 28 and and CC cord-010119-t1x9gknd 12046 29 time time NN cord-010119-t1x9gknd 12046 30 . . . cord-010119-t1x9gknd 12047 1 Study Study NNP cord-010119-t1x9gknd 12047 2 Design Design NNP cord-010119-t1x9gknd 12047 3 / / SYM cord-010119-t1x9gknd 12047 4 Method method NN cord-010119-t1x9gknd 12047 5 : : : cord-010119-t1x9gknd 12047 6 As as IN cord-010119-t1x9gknd 12047 7 part part NN cord-010119-t1x9gknd 12047 8 of of IN cord-010119-t1x9gknd 12047 9 a a DT cord-010119-t1x9gknd 12047 10 Performance Performance NNP cord-010119-t1x9gknd 12047 11 Improvement Improvement NNP cord-010119-t1x9gknd 12047 12 initiative initiative NN cord-010119-t1x9gknd 12047 13 in in IN cord-010119-t1x9gknd 12047 14 Transfusion Transfusion NNP cord-010119-t1x9gknd 12047 15 Medicine Medicine NNP cord-010119-t1x9gknd 12047 16 , , , cord-010119-t1x9gknd 12047 17 we -PRON- PRP cord-010119-t1x9gknd 12047 18 performed perform VBD cord-010119-t1x9gknd 12047 19 a a DT cord-010119-t1x9gknd 12047 20 retrospective retrospective JJ cord-010119-t1x9gknd 12047 21 study study NN cord-010119-t1x9gknd 12047 22 of of IN cord-010119-t1x9gknd 12047 23 all all DT cord-010119-t1x9gknd 12047 24 T&S T&S NNP cord-010119-t1x9gknd 12047 25 orders order NNS cord-010119-t1x9gknd 12047 26 that that WDT cord-010119-t1x9gknd 12047 27 were be VBD cord-010119-t1x9gknd 12047 28 initiated initiate VBN cord-010119-t1x9gknd 12047 29 in in IN cord-010119-t1x9gknd 12047 30 the the DT cord-010119-t1x9gknd 12047 31 ED ED NNP cord-010119-t1x9gknd 12047 32 from from IN cord-010119-t1x9gknd 12047 33 1/1/2015 1/1/2015 CD cord-010119-t1x9gknd 12047 34 to to IN cord-010119-t1x9gknd 12047 35 6/30/2015 6/30/2015 CD cord-010119-t1x9gknd 12047 36 to to TO cord-010119-t1x9gknd 12047 37 determine determine VB cord-010119-t1x9gknd 12047 38 if if IN cord-010119-t1x9gknd 12047 39 testing testing NN cord-010119-t1x9gknd 12047 40 was be VBD cord-010119-t1x9gknd 12047 41 subsequently subsequently RB cord-010119-t1x9gknd 12047 42 followed follow VBN cord-010119-t1x9gknd 12047 43 by by IN cord-010119-t1x9gknd 12047 44 transfusion transfusion NN cord-010119-t1x9gknd 12047 45 of of IN cord-010119-t1x9gknd 12047 46 blood blood NN cord-010119-t1x9gknd 12047 47 products product NNS cord-010119-t1x9gknd 12047 48 . . . cord-010119-t1x9gknd 12048 1 Patients patient NNS cord-010119-t1x9gknd 12048 2 were be VBD cord-010119-t1x9gknd 12048 3 stratified stratify VBN cord-010119-t1x9gknd 12048 4 by by IN cord-010119-t1x9gknd 12048 5 ED ED NNP cord-010119-t1x9gknd 12048 6 department department NN cord-010119-t1x9gknd 12048 7 , , , cord-010119-t1x9gknd 12048 8 time time NN cord-010119-t1x9gknd 12048 9 from from IN cord-010119-t1x9gknd 12048 10 T&S T&S NNP cord-010119-t1x9gknd 12048 11 draw draw NNP cord-010119-t1x9gknd 12048 12 ( ( -LRB- cord-010119-t1x9gknd 12048 13 TSD TSD NNP cord-010119-t1x9gknd 12048 14 ) ) -RRB- cord-010119-t1x9gknd 12048 15 to to IN cord-010119-t1x9gknd 12048 16 transfusion transfusion NN cord-010119-t1x9gknd 12048 17 ( ( -LRB- cord-010119-t1x9gknd 12048 18 < < NNP cord-010119-t1x9gknd 12048 19 4 4 CD cord-010119-t1x9gknd 12048 20 hours hour NNS cord-010119-t1x9gknd 12048 21 , , , cord-010119-t1x9gknd 12048 22 > > XX cord-010119-t1x9gknd 12048 23 4 4 CD cord-010119-t1x9gknd 12048 24 hours hour NNS cord-010119-t1x9gknd 12048 25 < < XX cord-010119-t1x9gknd 12048 26 24 24 CD cord-010119-t1x9gknd 12048 27 hours hour NNS cord-010119-t1x9gknd 12048 28 ) ) -RRB- cord-010119-t1x9gknd 12048 29 , , , cord-010119-t1x9gknd 12048 30 and and CC cord-010119-t1x9gknd 12048 31 if if IN cord-010119-t1x9gknd 12048 32 a a DT cord-010119-t1x9gknd 12048 33 second second JJ cord-010119-t1x9gknd 12048 34 sample sample NN cord-010119-t1x9gknd 12048 35 was be VBD cord-010119-t1x9gknd 12048 36 required require VBN cord-010119-t1x9gknd 12048 37 . . . cord-010119-t1x9gknd 12049 1 Results result NNS cord-010119-t1x9gknd 12049 2 / / SYM cord-010119-t1x9gknd 12049 3 Finding finding NN cord-010119-t1x9gknd 12049 4 : : : cord-010119-t1x9gknd 12049 5 A a DT cord-010119-t1x9gknd 12049 6 total total NN cord-010119-t1x9gknd 12049 7 of of IN cord-010119-t1x9gknd 12049 8 3144 3144 CD cord-010119-t1x9gknd 12049 9 T&S T&S NNP cord-010119-t1x9gknd 12049 10 orders order NNS cord-010119-t1x9gknd 12049 11 were be VBD cord-010119-t1x9gknd 12049 12 initiated initiate VBN cord-010119-t1x9gknd 12049 13 from from IN cord-010119-t1x9gknd 12049 14 the the DT cord-010119-t1x9gknd 12049 15 ED ED NNP cord-010119-t1x9gknd 12049 16 in in IN cord-010119-t1x9gknd 12049 17 this this DT cord-010119-t1x9gknd 12049 18 time time NN cord-010119-t1x9gknd 12049 19 period period NN cord-010119-t1x9gknd 12049 20 . . . cord-010119-t1x9gknd 12050 1 2787 2787 CD cord-010119-t1x9gknd 12050 2 ( ( -LRB- cord-010119-t1x9gknd 12050 3 88.7 88.7 CD cord-010119-t1x9gknd 12050 4 % % NN cord-010119-t1x9gknd 12050 5 ) ) -RRB- cord-010119-t1x9gknd 12050 6 patients patient NNS cord-010119-t1x9gknd 12050 7 were be VBD cord-010119-t1x9gknd 12050 8 not not RB cord-010119-t1x9gknd 12050 9 subsequently subsequently RB cord-010119-t1x9gknd 12050 10 transfused transfuse VBN cord-010119-t1x9gknd 12050 11 any any DT cord-010119-t1x9gknd 12050 12 type type NN cord-010119-t1x9gknd 12050 13 of of IN cord-010119-t1x9gknd 12050 14 blood blood NN cord-010119-t1x9gknd 12050 15 product product NN cord-010119-t1x9gknd 12050 16 within within IN cord-010119-t1x9gknd 12050 17 4 4 CD cord-010119-t1x9gknd 12050 18 hours hour NNS cord-010119-t1x9gknd 12050 19 of of IN cord-010119-t1x9gknd 12050 20 TSD TSD NNP cord-010119-t1x9gknd 12050 21 and and CC cord-010119-t1x9gknd 12050 22 2584 2584 CD cord-010119-t1x9gknd 12050 23 ( ( -LRB- cord-010119-t1x9gknd 12050 24 82.2 82.2 CD cord-010119-t1x9gknd 12050 25 % % NN cord-010119-t1x9gknd 12050 26 ) ) -RRB- cord-010119-t1x9gknd 12050 27 patients patient NNS cord-010119-t1x9gknd 12050 28 were be VBD cord-010119-t1x9gknd 12050 29 not not RB cord-010119-t1x9gknd 12050 30 subsequently subsequently RB cord-010119-t1x9gknd 12050 31 transfused transfuse VBN cord-010119-t1x9gknd 12050 32 any any DT cord-010119-t1x9gknd 12050 33 type type NN cord-010119-t1x9gknd 12050 34 of of IN cord-010119-t1x9gknd 12050 35 blood blood NN cord-010119-t1x9gknd 12050 36 product product NN cord-010119-t1x9gknd 12050 37 within within IN cord-010119-t1x9gknd 12050 38 24 24 CD cord-010119-t1x9gknd 12050 39 hours hour NNS cord-010119-t1x9gknd 12050 40 of of IN cord-010119-t1x9gknd 12050 41 TSD TSD NNP cord-010119-t1x9gknd 12050 42 . . . cord-010119-t1x9gknd 12051 1 A a DT cord-010119-t1x9gknd 12051 2 total total NN cord-010119-t1x9gknd 12051 3 of of IN cord-010119-t1x9gknd 12051 4 2119 2119 CD cord-010119-t1x9gknd 12051 5 ( ( -LRB- cord-010119-t1x9gknd 12051 6 67.3 67.3 CD cord-010119-t1x9gknd 12051 7 % % NN cord-010119-t1x9gknd 12051 8 ) ) -RRB- cord-010119-t1x9gknd 12051 9 patients patient NNS cord-010119-t1x9gknd 12051 10 required require VBD cord-010119-t1x9gknd 12051 11 a a DT cord-010119-t1x9gknd 12051 12 second second JJ cord-010119-t1x9gknd 12051 13 sample sample NN cord-010119-t1x9gknd 12051 14 . . . cord-010119-t1x9gknd 12052 1 Of of IN cord-010119-t1x9gknd 12052 2 these these DT cord-010119-t1x9gknd 12052 3 patients patient NNS cord-010119-t1x9gknd 12052 4 requiring require VBG cord-010119-t1x9gknd 12052 5 a a DT cord-010119-t1x9gknd 12052 6 second second JJ cord-010119-t1x9gknd 12052 7 sample sample NN cord-010119-t1x9gknd 12052 8 , , , cord-010119-t1x9gknd 12052 9 1960 1960 CD cord-010119-t1x9gknd 12052 10 ( ( -LRB- cord-010119-t1x9gknd 12052 11 92.5 92.5 CD cord-010119-t1x9gknd 12052 12 % % NN cord-010119-t1x9gknd 12052 13 ) ) -RRB- cord-010119-t1x9gknd 12052 14 were be VBD cord-010119-t1x9gknd 12052 15 not not RB cord-010119-t1x9gknd 12052 16 subsequently subsequently RB cord-010119-t1x9gknd 12052 17 transfused transfuse VBN cord-010119-t1x9gknd 12052 18 any any DT cord-010119-t1x9gknd 12052 19 type type NN cord-010119-t1x9gknd 12052 20 of of IN cord-010119-t1x9gknd 12052 21 blood blood NN cord-010119-t1x9gknd 12052 22 product product NN cord-010119-t1x9gknd 12052 23 within within IN cord-010119-t1x9gknd 12052 24 4 4 CD cord-010119-t1x9gknd 12052 25 hours hour NNS cord-010119-t1x9gknd 12052 26 of of IN cord-010119-t1x9gknd 12052 27 TSD TSD NNP cord-010119-t1x9gknd 12052 28 and and CC cord-010119-t1x9gknd 12052 29 1886 1886 CD cord-010119-t1x9gknd 12052 30 ( ( -LRB- cord-010119-t1x9gknd 12052 31 89 89 CD cord-010119-t1x9gknd 12052 32 % % NN cord-010119-t1x9gknd 12052 33 ) ) -RRB- cord-010119-t1x9gknd 12052 34 were be VBD cord-010119-t1x9gknd 12052 35 not not RB cord-010119-t1x9gknd 12052 36 subsequently subsequently RB cord-010119-t1x9gknd 12052 37 transfused transfuse VBN cord-010119-t1x9gknd 12052 38 any any DT cord-010119-t1x9gknd 12052 39 type type NN cord-010119-t1x9gknd 12052 40 of of IN cord-010119-t1x9gknd 12052 41 blood blood NN cord-010119-t1x9gknd 12052 42 product product NN cord-010119-t1x9gknd 12052 43 within within IN cord-010119-t1x9gknd 12052 44 24 24 CD cord-010119-t1x9gknd 12052 45 hours hour NNS cord-010119-t1x9gknd 12052 46 of of IN cord-010119-t1x9gknd 12052 47 TSD TSD NNP cord-010119-t1x9gknd 12052 48 . . . cord-010119-t1x9gknd 12053 1 Conclusion conclusion NN cord-010119-t1x9gknd 12053 2 : : : cord-010119-t1x9gknd 12053 3 Routine routine JJ cord-010119-t1x9gknd 12053 4 ordering ordering NN cord-010119-t1x9gknd 12053 5 of of IN cord-010119-t1x9gknd 12053 6 T&S t&s NN cord-010119-t1x9gknd 12053 7 testing testing NN cord-010119-t1x9gknd 12053 8 is be VBZ cord-010119-t1x9gknd 12053 9 not not RB cord-010119-t1x9gknd 12053 10 an an DT cord-010119-t1x9gknd 12053 11 efficient efficient JJ cord-010119-t1x9gknd 12053 12 use use NN cord-010119-t1x9gknd 12053 13 of of IN cord-010119-t1x9gknd 12053 14 resources resource NNS cord-010119-t1x9gknd 12053 15 and and CC cord-010119-t1x9gknd 12053 16 time time NN cord-010119-t1x9gknd 12053 17 as as IN cord-010119-t1x9gknd 12053 18 many many JJ cord-010119-t1x9gknd 12053 19 patients patient NNS cord-010119-t1x9gknd 12053 20 are be VBP cord-010119-t1x9gknd 12053 21 not not RB cord-010119-t1x9gknd 12053 22 subsequently subsequently RB cord-010119-t1x9gknd 12053 23 transfused transfuse VBN cord-010119-t1x9gknd 12053 24 . . . cord-010119-t1x9gknd 12054 1 Ultimately ultimately RB cord-010119-t1x9gknd 12054 2 unnecessary unnecessary JJ cord-010119-t1x9gknd 12054 3 T&S t&s NN cord-010119-t1x9gknd 12054 4 and and CC cord-010119-t1x9gknd 12054 5 second second JJ cord-010119-t1x9gknd 12054 6 sample sample NN cord-010119-t1x9gknd 12054 7 collection collection NN cord-010119-t1x9gknd 12054 8 and and CC cord-010119-t1x9gknd 12054 9 testing testing NN cord-010119-t1x9gknd 12054 10 for for IN cord-010119-t1x9gknd 12054 11 those those DT cord-010119-t1x9gknd 12054 12 patients patient NNS cord-010119-t1x9gknd 12054 13 not not RB cord-010119-t1x9gknd 12054 14 subsequently subsequently RB cord-010119-t1x9gknd 12054 15 transfused transfuse VBN cord-010119-t1x9gknd 12054 16 within within IN cord-010119-t1x9gknd 12054 17 24 24 CD cord-010119-t1x9gknd 12054 18 hours hour NNS cord-010119-t1x9gknd 12054 19 of of IN cord-010119-t1x9gknd 12054 20 TSD TSD NNP cord-010119-t1x9gknd 12054 21 amounted amount VBD cord-010119-t1x9gknd 12054 22 to to IN cord-010119-t1x9gknd 12054 23 an an DT cord-010119-t1x9gknd 12054 24 estimated estimate VBN cord-010119-t1x9gknd 12054 25 $ $ $ cord-010119-t1x9gknd 12054 26 699,706 699,706 CD cord-010119-t1x9gknd 12054 27 in in IN cord-010119-t1x9gknd 12054 28 unnecessary unnecessary JJ cord-010119-t1x9gknd 12054 29 patient patient NN cord-010119-t1x9gknd 12054 30 charges charge NNS cord-010119-t1x9gknd 12054 31 and and CC cord-010119-t1x9gknd 12054 32 approximately approximately RB cord-010119-t1x9gknd 12054 33 628.7 628.7 CD cord-010119-t1x9gknd 12054 34 nursing nursing NN cord-010119-t1x9gknd 12054 35 hours hour NNS cord-010119-t1x9gknd 12054 36 for for IN cord-010119-t1x9gknd 12054 37 phlebotomies phlebotomy NNS cord-010119-t1x9gknd 12054 38 in in IN cord-010119-t1x9gknd 12054 39 a a DT cord-010119-t1x9gknd 12054 40 six six CD cord-010119-t1x9gknd 12054 41 month month NN cord-010119-t1x9gknd 12054 42 period period NN cord-010119-t1x9gknd 12054 43 . . . cord-010119-t1x9gknd 12055 1 Anti anti JJ cord-010119-t1x9gknd 12055 2 - - NN cord-010119-t1x9gknd 12055 3 D d JJ cord-010119-t1x9gknd 12055 4 from from IN cord-010119-t1x9gknd 12055 5 Alloimmunization Alloimmunization NNP cord-010119-t1x9gknd 12055 6 Versus Versus NNP cord-010119-t1x9gknd 12055 7 Rh Rh NNP cord-010119-t1x9gknd 12055 8 Immune Immune NNP cord-010119-t1x9gknd 12055 9 Globulin globulin NN cord-010119-t1x9gknd 12055 10 : : : cord-010119-t1x9gknd 12055 11 Detective Detective NNP cord-010119-t1x9gknd 12055 12 Work work NN cord-010119-t1x9gknd 12055 13 in in IN cord-010119-t1x9gknd 12055 14 the the DT cord-010119-t1x9gknd 12055 15 Blood Blood NNP cord-010119-t1x9gknd 12055 16 Bank Bank NNP cord-010119-t1x9gknd 12055 17 and and CC cord-010119-t1x9gknd 12055 18 Transfusion Transfusion NNP cord-010119-t1x9gknd 12055 19 Medicine Medicine NNP cord-010119-t1x9gknd 12055 20 Services Services NNPS cord-010119-t1x9gknd 12055 21 ( ( -LRB- cord-010119-t1x9gknd 12055 22 BBTMS BBTMS NNP cord-010119-t1x9gknd 12055 23 ) ) -RRB- cord-010119-t1x9gknd 12055 24 Margaret Margaret NNP cord-010119-t1x9gknd 12055 25 DiGuardo DiGuardo NNP cord-010119-t1x9gknd 12055 26 * * NFP cord-010119-t1x9gknd 12055 27 1 1 CD cord-010119-t1x9gknd 12055 28 , , , cord-010119-t1x9gknd 12055 29 Debra Debra NNP cord-010119-t1x9gknd 12055 30 Berry Berry NNP cord-010119-t1x9gknd 12055 31 1 1 CD cord-010119-t1x9gknd 12055 32 , , , cord-010119-t1x9gknd 12055 33 Yunchuan Yunchuan NNP cord-010119-t1x9gknd 12055 34 Delores Delores NNP cord-010119-t1x9gknd 12055 35 Mo Mo NNP cord-010119-t1x9gknd 12055 36 2 2 CD cord-010119-t1x9gknd 12055 37 and and CC cord-010119-t1x9gknd 12055 38 Gay Gay NNP cord-010119-t1x9gknd 12055 39 Wehrli Wehrli NNP cord-010119-t1x9gknd 12055 40 1 1 CD cord-010119-t1x9gknd 12055 41 . . . cord-010119-t1x9gknd 12056 1 1 1 CD cord-010119-t1x9gknd 12056 2 University University NNP cord-010119-t1x9gknd 12056 3 of of IN cord-010119-t1x9gknd 12056 4 Virginia Virginia NNP cord-010119-t1x9gknd 12056 5 Health Health NNP cord-010119-t1x9gknd 12056 6 System System NNP cord-010119-t1x9gknd 12056 7 , , , cord-010119-t1x9gknd 12056 8 2 2 CD cord-010119-t1x9gknd 12056 9 Children Children NNPS cord-010119-t1x9gknd 12056 10 's 's POS cord-010119-t1x9gknd 12056 11 National National NNP cord-010119-t1x9gknd 12056 12 Medical Medical NNP cord-010119-t1x9gknd 12056 13 Center Center NNP cord-010119-t1x9gknd 12056 14 Background Background NNP cord-010119-t1x9gknd 12056 15 / / SYM cord-010119-t1x9gknd 12056 16 Case Case NNP cord-010119-t1x9gknd 12056 17 Studies Studies NNPS cord-010119-t1x9gknd 12056 18 : : : cord-010119-t1x9gknd 12057 1 The the DT cord-010119-t1x9gknd 12057 2 Institute Institute NNP cord-010119-t1x9gknd 12057 3 for for IN cord-010119-t1x9gknd 12057 4 Healthcare Healthcare NNP cord-010119-t1x9gknd 12057 5 Improvement Improvement NNP cord-010119-t1x9gknd 12057 6 Triple Triple NNP cord-010119-t1x9gknd 12057 7 Aim Aim NNP cord-010119-t1x9gknd 12057 8 incorporates incorporate VBZ cord-010119-t1x9gknd 12057 9 enhancing enhance VBG cord-010119-t1x9gknd 12057 10 patient patient JJ cord-010119-t1x9gknd 12057 11 satisfaction satisfaction NN cord-010119-t1x9gknd 12057 12 by by IN cord-010119-t1x9gknd 12057 13 providing provide VBG cord-010119-t1x9gknd 12057 14 high high JJ cord-010119-t1x9gknd 12057 15 quality quality NN cord-010119-t1x9gknd 12057 16 , , , cord-010119-t1x9gknd 12057 17 safe safe JJ cord-010119-t1x9gknd 12057 18 care care NN cord-010119-t1x9gknd 12057 19 . . . cord-010119-t1x9gknd 12058 1 Towards towards IN cord-010119-t1x9gknd 12058 2 these these DT cord-010119-t1x9gknd 12058 3 goals goal NNS cord-010119-t1x9gknd 12058 4 the the DT cord-010119-t1x9gknd 12058 5 BBTMS BBTMS NNP cord-010119-t1x9gknd 12058 6 is be VBZ cord-010119-t1x9gknd 12058 7 charged charge VBN cord-010119-t1x9gknd 12058 8 with with IN cord-010119-t1x9gknd 12058 9 communicating communicate VBG cord-010119-t1x9gknd 12058 10 to to IN cord-010119-t1x9gknd 12058 11 obstetric obstetric JJ cord-010119-t1x9gknd 12058 12 physicians physician NNS cord-010119-t1x9gknd 12058 13 ( ( -LRB- cord-010119-t1x9gknd 12058 14 OBs OBs NNPS cord-010119-t1x9gknd 12058 15 ) ) -RRB- cord-010119-t1x9gknd 12058 16 a a DT cord-010119-t1x9gknd 12058 17 patient patient NN cord-010119-t1x9gknd 12058 18 's 's POS cord-010119-t1x9gknd 12058 19 antibody antibody NN cord-010119-t1x9gknd 12058 20 specificity specificity NN cord-010119-t1x9gknd 12058 21 with with IN cord-010119-t1x9gknd 12058 22 associated associated JJ cord-010119-t1x9gknd 12058 23 hemolytic hemolytic JJ cord-010119-t1x9gknd 12058 24 disease disease NN cord-010119-t1x9gknd 12058 25 of of IN cord-010119-t1x9gknd 12058 26 the the DT cord-010119-t1x9gknd 12058 27 fetus fetus NN cord-010119-t1x9gknd 12058 28 / / SYM cord-010119-t1x9gknd 12058 29 newborn newborn JJ cord-010119-t1x9gknd 12058 30 risk risk NN cord-010119-t1x9gknd 12058 31 . . . cord-010119-t1x9gknd 12059 1 Thus thus RB cord-010119-t1x9gknd 12059 2 , , , cord-010119-t1x9gknd 12059 3 when when WRB cord-010119-t1x9gknd 12059 4 anti anti JJ cord-010119-t1x9gknd 12059 5 - - JJ cord-010119-t1x9gknd 12059 6 D d JJ cord-010119-t1x9gknd 12059 7 is be VBZ cord-010119-t1x9gknd 12059 8 detected detect VBN cord-010119-t1x9gknd 12059 9 in in IN cord-010119-t1x9gknd 12059 10 a a DT cord-010119-t1x9gknd 12059 11 female female NN cord-010119-t1x9gknd 12059 12 of of IN cord-010119-t1x9gknd 12059 13 childbearing childbeare VBG cord-010119-t1x9gknd 12059 14 age age NN cord-010119-t1x9gknd 12059 15 , , , cord-010119-t1x9gknd 12059 16 it -PRON- PRP cord-010119-t1x9gknd 12059 17 is be VBZ cord-010119-t1x9gknd 12059 18 critical critical JJ cord-010119-t1x9gknd 12059 19 to to TO cord-010119-t1x9gknd 12059 20 determine determine VB cord-010119-t1x9gknd 12059 21 whether whether IN cord-010119-t1x9gknd 12059 22 this this DT cord-010119-t1x9gknd 12059 23 represents represent VBZ cord-010119-t1x9gknd 12059 24 Rh Rh NNP cord-010119-t1x9gknd 12059 25 immune immune JJ cord-010119-t1x9gknd 12059 26 globulin globulin NN cord-010119-t1x9gknd 12059 27 ( ( -LRB- cord-010119-t1x9gknd 12059 28 RhIG RhIG NNP cord-010119-t1x9gknd 12059 29 ) ) -RRB- cord-010119-t1x9gknd 12059 30 or or CC cord-010119-t1x9gknd 12059 31 alloimmunization alloimmunization NN cord-010119-t1x9gknd 12059 32 ( ( -LRB- cord-010119-t1x9gknd 12059 33 alloanti alloanti NNP cord-010119-t1x9gknd 12059 34 - - HYPH cord-010119-t1x9gknd 12059 35 D D NNP cord-010119-t1x9gknd 12059 36 ) ) -RRB- cord-010119-t1x9gknd 12059 37 . . . cord-010119-t1x9gknd 12060 1 Review Review NNP cord-010119-t1x9gknd 12060 2 of of IN cord-010119-t1x9gknd 12060 3 a a DT cord-010119-t1x9gknd 12060 4 patient patient NN cord-010119-t1x9gknd 12060 5 's 's POS cord-010119-t1x9gknd 12060 6 electronic electronic JJ cord-010119-t1x9gknd 12060 7 health health NN cord-010119-t1x9gknd 12060 8 record record NN cord-010119-t1x9gknd 12060 9 ( ( -LRB- cord-010119-t1x9gknd 12060 10 EHR EHR NNP cord-010119-t1x9gknd 12060 11 ) ) -RRB- cord-010119-t1x9gknd 12060 12 helps help VBZ cord-010119-t1x9gknd 12060 13 quickly quickly RB cord-010119-t1x9gknd 12060 14 identify identify VB cord-010119-t1x9gknd 12060 15 RhIG RhIG NNP cord-010119-t1x9gknd 12060 16 administration administration NN cord-010119-t1x9gknd 12060 17 , , , cord-010119-t1x9gknd 12060 18 but but CC cord-010119-t1x9gknd 12060 19 if if IN cord-010119-t1x9gknd 12060 20 this this DT cord-010119-t1x9gknd 12060 21 documentation documentation NN cord-010119-t1x9gknd 12060 22 is be VBZ cord-010119-t1x9gknd 12060 23 missing miss VBG cord-010119-t1x9gknd 12060 24 , , , cord-010119-t1x9gknd 12060 25 then then RB cord-010119-t1x9gknd 12060 26 it -PRON- PRP cord-010119-t1x9gknd 12060 27 is be VBZ cord-010119-t1x9gknd 12060 28 easy easy JJ cord-010119-t1x9gknd 12060 29 to to TO cord-010119-t1x9gknd 12060 30 assume assume VB cord-010119-t1x9gknd 12060 31 presence presence NN cord-010119-t1x9gknd 12060 32 of of IN cord-010119-t1x9gknd 12060 33 alloanti alloanti NNP cord-010119-t1x9gknd 12060 34 - - HYPH cord-010119-t1x9gknd 12060 35 D. D. NNP cord-010119-t1x9gknd 12060 36 RhD RhD NNP cord-010119-t1x9gknd 12060 37 alloimmunization alloimmunization NNP cord-010119-t1x9gknd 12060 38 impacts impact NNS cord-010119-t1x9gknd 12060 39 mom mom NN cord-010119-t1x9gknd 12060 40 , , , cord-010119-t1x9gknd 12060 41 fetus fetus NN cord-010119-t1x9gknd 12060 42 , , , cord-010119-t1x9gknd 12060 43 newborn newborn JJ cord-010119-t1x9gknd 12060 44 and and CC cord-010119-t1x9gknd 12060 45 future future JJ cord-010119-t1x9gknd 12060 46 pregnancies pregnancy NNS cord-010119-t1x9gknd 12060 47 . . . cord-010119-t1x9gknd 12061 1 Therefore therefore RB cord-010119-t1x9gknd 12061 2 , , , cord-010119-t1x9gknd 12061 3 without without IN cord-010119-t1x9gknd 12061 4 a a DT cord-010119-t1x9gknd 12061 5 national national JJ cord-010119-t1x9gknd 12061 6 , , , cord-010119-t1x9gknd 12061 7 comprehensive comprehensive JJ cord-010119-t1x9gknd 12061 8 health health NN cord-010119-t1x9gknd 12061 9 information information NN cord-010119-t1x9gknd 12061 10 exchange exchange NN cord-010119-t1x9gknd 12061 11 ( ( -LRB- cord-010119-t1x9gknd 12061 12 HIE HIE NNP cord-010119-t1x9gknd 12061 13 ) ) -RRB- cord-010119-t1x9gknd 12061 14 system system NN cord-010119-t1x9gknd 12061 15 , , , cord-010119-t1x9gknd 12061 16 it -PRON- PRP cord-010119-t1x9gknd 12061 17 is be VBZ cord-010119-t1x9gknd 12061 18 imperative imperative JJ cord-010119-t1x9gknd 12061 19 to to TO cord-010119-t1x9gknd 12061 20 investigate investigate VB cord-010119-t1x9gknd 12061 21 beyond beyond IN cord-010119-t1x9gknd 12061 22 the the DT cord-010119-t1x9gknd 12061 23 on on IN cord-010119-t1x9gknd 12061 24 - - HYPH cord-010119-t1x9gknd 12061 25 site site NN cord-010119-t1x9gknd 12061 26 EHR EHR NNP cord-010119-t1x9gknd 12061 27 whether whether IN cord-010119-t1x9gknd 12061 28 a a DT cord-010119-t1x9gknd 12061 29 patient patient NN cord-010119-t1x9gknd 12061 30 received receive VBD cord-010119-t1x9gknd 12061 31 RhIG rhig NN cord-010119-t1x9gknd 12061 32 at at IN cord-010119-t1x9gknd 12061 33 an an DT cord-010119-t1x9gknd 12061 34 outside outside JJ cord-010119-t1x9gknd 12061 35 hospital hospital NN cord-010119-t1x9gknd 12061 36 ( ( -LRB- cord-010119-t1x9gknd 12061 37 OH oh UH cord-010119-t1x9gknd 12061 38 ) ) -RRB- cord-010119-t1x9gknd 12061 39 . . . cord-010119-t1x9gknd 12062 1 We -PRON- PRP cord-010119-t1x9gknd 12062 2 report report VBP cord-010119-t1x9gknd 12062 3 an an DT cord-010119-t1x9gknd 12062 4 IRB IRB NNP cord-010119-t1x9gknd 12062 5 approved approve VBN cord-010119-t1x9gknd 12062 6 ( ( -LRB- cord-010119-t1x9gknd 12062 7 exempt exempt JJ cord-010119-t1x9gknd 12062 8 ) ) -RRB- cord-010119-t1x9gknd 12062 9 case case NN cord-010119-t1x9gknd 12062 10 series series NN cord-010119-t1x9gknd 12062 11 where where WRB cord-010119-t1x9gknd 12062 12 detective detective NN cord-010119-t1x9gknd 12062 13 work work NN cord-010119-t1x9gknd 12062 14 revealed reveal VBD cord-010119-t1x9gknd 12062 15 RhIG RhIG NNP cord-010119-t1x9gknd 12062 16 administration administration NN cord-010119-t1x9gknd 12062 17 at at IN cord-010119-t1x9gknd 12062 18 OHs OHs NNP cord-010119-t1x9gknd 12062 19 . . . cord-010119-t1x9gknd 12063 1 Study Study NNP cord-010119-t1x9gknd 12063 2 Design Design NNP cord-010119-t1x9gknd 12063 3 / / SYM cord-010119-t1x9gknd 12063 4 Method method NN cord-010119-t1x9gknd 12063 5 : : : cord-010119-t1x9gknd 12064 1 Over over IN cord-010119-t1x9gknd 12064 2 a a DT cord-010119-t1x9gknd 12064 3 two two CD cord-010119-t1x9gknd 12064 4 month month NN cord-010119-t1x9gknd 12064 5 time time NN cord-010119-t1x9gknd 12064 6 period period NN cord-010119-t1x9gknd 12064 7 , , , cord-010119-t1x9gknd 12064 8 anti anti JJ cord-010119-t1x9gknd 12064 9 - - NNP cord-010119-t1x9gknd 12064 10 D D NNP cord-010119-t1x9gknd 12064 11 was be VBD cord-010119-t1x9gknd 12064 12 identified identify VBN cord-010119-t1x9gknd 12064 13 in in IN cord-010119-t1x9gknd 12064 14 four four CD cord-010119-t1x9gknd 12064 15 pregnant pregnant JJ cord-010119-t1x9gknd 12064 16 women woman NNS cord-010119-t1x9gknd 12064 17 . . . cord-010119-t1x9gknd 12065 1 Review review NN cord-010119-t1x9gknd 12065 2 of of IN cord-010119-t1x9gknd 12065 3 their -PRON- PRP$ cord-010119-t1x9gknd 12065 4 EHRs ehr NNS cord-010119-t1x9gknd 12065 5 did do VBD cord-010119-t1x9gknd 12065 6 not not RB cord-010119-t1x9gknd 12065 7 reveal reveal VB cord-010119-t1x9gknd 12065 8 a a DT cord-010119-t1x9gknd 12065 9 history history NN cord-010119-t1x9gknd 12065 10 of of IN cord-010119-t1x9gknd 12065 11 ABSTRACT abstract JJ cord-010119-t1x9gknd 12065 12 RhIG RhIG NNP cord-010119-t1x9gknd 12065 13 administration administration NN cord-010119-t1x9gknd 12065 14 ; ; : cord-010119-t1x9gknd 12065 15 nor nor CC cord-010119-t1x9gknd 12065 16 did do VBD cord-010119-t1x9gknd 12065 17 subsequent subsequent JJ cord-010119-t1x9gknd 12065 18 direct direct JJ cord-010119-t1x9gknd 12065 19 communication communication NN cord-010119-t1x9gknd 12065 20 with with IN cord-010119-t1x9gknd 12065 21 their -PRON- PRP$ cord-010119-t1x9gknd 12065 22 obstetricians obstetrician NNS cord-010119-t1x9gknd 12065 23 ( ( -LRB- cord-010119-t1x9gknd 12065 24 OB OB NNP cord-010119-t1x9gknd 12065 25 ) ) -RRB- cord-010119-t1x9gknd 12065 26 reveal reveal VBP cord-010119-t1x9gknd 12065 27 a a DT cord-010119-t1x9gknd 12065 28 history history NN cord-010119-t1x9gknd 12065 29 of of IN cord-010119-t1x9gknd 12065 30 RhIG rhig NN cord-010119-t1x9gknd 12065 31 . . . cord-010119-t1x9gknd 12066 1 Based base VBN cord-010119-t1x9gknd 12066 2 on on IN cord-010119-t1x9gknd 12066 3 each each DT cord-010119-t1x9gknd 12066 4 patient patient NN cord-010119-t1x9gknd 12066 5 's 's POS cord-010119-t1x9gknd 12066 6 home home NN cord-010119-t1x9gknd 12066 7 address address NN cord-010119-t1x9gknd 12066 8 , , , cord-010119-t1x9gknd 12066 9 the the DT cord-010119-t1x9gknd 12066 10 BBTMS BBTMS NNP cord-010119-t1x9gknd 12066 11 of of IN cord-010119-t1x9gknd 12066 12 any any DT cord-010119-t1x9gknd 12066 13 nearby nearby JJ cord-010119-t1x9gknd 12066 14 OHs OHs NNP cord-010119-t1x9gknd 12066 15 were be VBD cord-010119-t1x9gknd 12066 16 contacted contact VBN cord-010119-t1x9gknd 12066 17 as as IN cord-010119-t1x9gknd 12066 18 was be VBD cord-010119-t1x9gknd 12066 19 a a DT cord-010119-t1x9gknd 12066 20 primary primary JJ cord-010119-t1x9gknd 12066 21 care care NN cord-010119-t1x9gknd 12066 22 physician physician NN cord-010119-t1x9gknd 12066 23 if if IN cord-010119-t1x9gknd 12066 24 listed list VBN cord-010119-t1x9gknd 12066 25 in in IN cord-010119-t1x9gknd 12066 26 the the DT cord-010119-t1x9gknd 12066 27 EHR EHR NNP cord-010119-t1x9gknd 12066 28 . . . cord-010119-t1x9gknd 12067 1 Results/ Results/ . cord-010119-t1x9gknd 12068 1 Finding finding NN cord-010119-t1x9gknd 12068 2 : : : cord-010119-t1x9gknd 12069 1 Investigations investigation NNS cord-010119-t1x9gknd 12069 2 beyond beyond IN cord-010119-t1x9gknd 12069 3 the the DT cord-010119-t1x9gknd 12069 4 EHR EHR NNP cord-010119-t1x9gknd 12069 5 and and CC cord-010119-t1x9gknd 12069 6 OBs OBs NNPS cord-010119-t1x9gknd 12069 7 revealed reveal VBD cord-010119-t1x9gknd 12069 8 each each DT cord-010119-t1x9gknd 12069 9 of of IN cord-010119-t1x9gknd 12069 10 the the DT cord-010119-t1x9gknd 12069 11 four four CD cord-010119-t1x9gknd 12069 12 patients patient NNS cord-010119-t1x9gknd 12069 13 received receive VBD cord-010119-t1x9gknd 12069 14 discontinuous discontinuous JJ cord-010119-t1x9gknd 12069 15 prenatal prenatal JJ cord-010119-t1x9gknd 12069 16 care care NN cord-010119-t1x9gknd 12069 17 with with IN cord-010119-t1x9gknd 12069 18 presentations presentation NNS cord-010119-t1x9gknd 12069 19 at at IN cord-010119-t1x9gknd 12069 20 multiple multiple JJ cord-010119-t1x9gknd 12069 21 sites site NNS cord-010119-t1x9gknd 12069 22 . . . cord-010119-t1x9gknd 12070 1 Through through IN cord-010119-t1x9gknd 12070 2 phone phone NN cord-010119-t1x9gknd 12070 3 calls call NNS cord-010119-t1x9gknd 12070 4 to to IN cord-010119-t1x9gknd 12070 5 the the DT cord-010119-t1x9gknd 12070 6 BBTMS BBTMS NNP cord-010119-t1x9gknd 12070 7 of of IN cord-010119-t1x9gknd 12070 8 OHs OHs NNP cord-010119-t1x9gknd 12070 9 , , , cord-010119-t1x9gknd 12070 10 a a DT cord-010119-t1x9gknd 12070 11 history history NN cord-010119-t1x9gknd 12070 12 of of IN cord-010119-t1x9gknd 12070 13 one one CD cord-010119-t1x9gknd 12070 14 or or CC cord-010119-t1x9gknd 12070 15 more more JJR cord-010119-t1x9gknd 12070 16 RhIG rhig NN cord-010119-t1x9gknd 12070 17 administrations administration NNS cord-010119-t1x9gknd 12070 18 within within IN cord-010119-t1x9gknd 12070 19 the the DT cord-010119-t1x9gknd 12070 20 preceding precede VBG cord-010119-t1x9gknd 12070 21 three three CD cord-010119-t1x9gknd 12070 22 months month NNS cord-010119-t1x9gknd 12070 23 was be VBD cord-010119-t1x9gknd 12070 24 found find VBN cord-010119-t1x9gknd 12070 25 for for IN cord-010119-t1x9gknd 12070 26 each each DT cord-010119-t1x9gknd 12070 27 patient patient NN cord-010119-t1x9gknd 12070 28 . . . cord-010119-t1x9gknd 12071 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12071 2 BBTMS BBTMS NNP cord-010119-t1x9gknd 12071 3 records record NNS cord-010119-t1x9gknd 12071 4 and and CC cord-010119-t1x9gknd 12071 5 EHR EHR NNP cord-010119-t1x9gknd 12071 6 were be VBD cord-010119-t1x9gknd 12071 7 amended amend VBN cord-010119-t1x9gknd 12071 8 to to TO cord-010119-t1x9gknd 12071 9 reflect reflect VB cord-010119-t1x9gknd 12071 10 the the DT cord-010119-t1x9gknd 12071 11 presence presence NN cord-010119-t1x9gknd 12071 12 of of IN cord-010119-t1x9gknd 12071 13 a a DT cord-010119-t1x9gknd 12071 14 passive passive JJ cord-010119-t1x9gknd 12071 15 anti anti JJ cord-010119-t1x9gknd 12071 16 - - JJ cord-010119-t1x9gknd 12071 17 D d JJ cord-010119-t1x9gknd 12071 18 due due IN cord-010119-t1x9gknd 12071 19 to to IN cord-010119-t1x9gknd 12071 20 RhIG rhig NN cord-010119-t1x9gknd 12071 21 , , , cord-010119-t1x9gknd 12071 22 rather rather RB cord-010119-t1x9gknd 12071 23 than than IN cord-010119-t1x9gknd 12071 24 alloanti alloanti NNP cord-010119-t1x9gknd 12071 25 - - HYPH cord-010119-t1x9gknd 12071 26 D. D. NNP cord-010119-t1x9gknd 12072 1 The the DT cord-010119-t1x9gknd 12072 2 changes change NNS cord-010119-t1x9gknd 12072 3 were be VBD cord-010119-t1x9gknd 12072 4 also also RB cord-010119-t1x9gknd 12072 5 directly directly RB cord-010119-t1x9gknd 12072 6 communicated communicate VBN cord-010119-t1x9gknd 12072 7 with with IN cord-010119-t1x9gknd 12072 8 the the DT cord-010119-t1x9gknd 12072 9 OB OB NNP cord-010119-t1x9gknd 12072 10 caring care VBG cord-010119-t1x9gknd 12072 11 for for IN cord-010119-t1x9gknd 12072 12 each each DT cord-010119-t1x9gknd 12072 13 patient patient NN cord-010119-t1x9gknd 12072 14 . . . cord-010119-t1x9gknd 12073 1 Conclusion conclusion NN cord-010119-t1x9gknd 12073 2 : : : cord-010119-t1x9gknd 12073 3 When when WRB cord-010119-t1x9gknd 12073 4 a a DT cord-010119-t1x9gknd 12073 5 new new JJ cord-010119-t1x9gknd 12073 6 anti anti JJ cord-010119-t1x9gknd 12073 7 - - JJ cord-010119-t1x9gknd 12073 8 D d JJ cord-010119-t1x9gknd 12073 9 is be VBZ cord-010119-t1x9gknd 12073 10 identified identify VBN cord-010119-t1x9gknd 12073 11 in in IN cord-010119-t1x9gknd 12073 12 a a DT cord-010119-t1x9gknd 12073 13 pregnant pregnant JJ cord-010119-t1x9gknd 12073 14 female female NN cord-010119-t1x9gknd 12073 15 , , , cord-010119-t1x9gknd 12073 16 investigation investigation NN cord-010119-t1x9gknd 12073 17 is be VBZ cord-010119-t1x9gknd 12073 18 required require VBN cord-010119-t1x9gknd 12073 19 to to TO cord-010119-t1x9gknd 12073 20 determine determine VB cord-010119-t1x9gknd 12073 21 whether whether IN cord-010119-t1x9gknd 12073 22 it -PRON- PRP cord-010119-t1x9gknd 12073 23 is be VBZ cord-010119-t1x9gknd 12073 24 passive passive JJ cord-010119-t1x9gknd 12073 25 RhIG rhig NN cord-010119-t1x9gknd 12073 26 versus versus IN cord-010119-t1x9gknd 12073 27 alloanti alloanti NNP cord-010119-t1x9gknd 12073 28 - - HYPH cord-010119-t1x9gknd 12073 29 D. D. NNP cord-010119-t1x9gknd 12074 1 When when WRB cord-010119-t1x9gknd 12074 2 neither neither CC cord-010119-t1x9gknd 12074 3 the the DT cord-010119-t1x9gknd 12074 4 EHR EHR NNP cord-010119-t1x9gknd 12074 5 patient patient NN cord-010119-t1x9gknd 12074 6 history history NN cord-010119-t1x9gknd 12074 7 or or CC cord-010119-t1x9gknd 12074 8 OB OB NNP cord-010119-t1x9gknd 12074 9 reveal reveal VBP cord-010119-t1x9gknd 12074 10 a a DT cord-010119-t1x9gknd 12074 11 RhIG rhig NN cord-010119-t1x9gknd 12074 12 history history NN cord-010119-t1x9gknd 12074 13 , , , cord-010119-t1x9gknd 12074 14 it -PRON- PRP cord-010119-t1x9gknd 12074 15 remains remain VBZ cord-010119-t1x9gknd 12074 16 in in IN cord-010119-t1x9gknd 12074 17 the the DT cord-010119-t1x9gknd 12074 18 patient patient NN cord-010119-t1x9gknd 12074 19 's 's POS cord-010119-t1x9gknd 12074 20 best good JJS cord-010119-t1x9gknd 12074 21 interest interest NN cord-010119-t1x9gknd 12074 22 to to TO cord-010119-t1x9gknd 12074 23 investigate investigate VB cord-010119-t1x9gknd 12074 24 further further RB cord-010119-t1x9gknd 12074 25 . . . cord-010119-t1x9gknd 12075 1 Through through IN cord-010119-t1x9gknd 12075 2 phone phone NN cord-010119-t1x9gknd 12075 3 calls call NNS cord-010119-t1x9gknd 12075 4 to to IN cord-010119-t1x9gknd 12075 5 OH oh UH cord-010119-t1x9gknd 12075 6 we -PRON- PRP cord-010119-t1x9gknd 12075 7 revealed reveal VBD cord-010119-t1x9gknd 12075 8 a a DT cord-010119-t1x9gknd 12075 9 history history NN cord-010119-t1x9gknd 12075 10 of of IN cord-010119-t1x9gknd 12075 11 RhIG RhIG NNP cord-010119-t1x9gknd 12075 12 administration administration NN cord-010119-t1x9gknd 12075 13 in in IN cord-010119-t1x9gknd 12075 14 four four CD cord-010119-t1x9gknd 12075 15 patients patient NNS cord-010119-t1x9gknd 12075 16 . . . cord-010119-t1x9gknd 12076 1 Finding find VBG cord-010119-t1x9gknd 12076 2 and and CC cord-010119-t1x9gknd 12076 3 communicating communicate VBG cord-010119-t1x9gknd 12076 4 this this DT cord-010119-t1x9gknd 12076 5 critical critical JJ cord-010119-t1x9gknd 12076 6 information information NN cord-010119-t1x9gknd 12076 7 helps help VBZ cord-010119-t1x9gknd 12076 8 enhance enhance VB cord-010119-t1x9gknd 12076 9 the the DT cord-010119-t1x9gknd 12076 10 quality quality NN cord-010119-t1x9gknd 12076 11 and and CC cord-010119-t1x9gknd 12076 12 safety safety NN cord-010119-t1x9gknd 12076 13 of of IN cord-010119-t1x9gknd 12076 14 patient patient NN cord-010119-t1x9gknd 12076 15 by by IN cord-010119-t1x9gknd 12076 16 ensuring ensure VBG cord-010119-t1x9gknd 12076 17 subsequent subsequent JJ cord-010119-t1x9gknd 12076 18 RhIG rhig NN cord-010119-t1x9gknd 12076 19 administrations administration NNS cord-010119-t1x9gknd 12076 20 when when WRB cord-010119-t1x9gknd 12076 21 indicated indicate VBN cord-010119-t1x9gknd 12076 22 , , , cord-010119-t1x9gknd 12076 23 at at IN cord-010119-t1x9gknd 12076 24 our -PRON- PRP$ cord-010119-t1x9gknd 12076 25 institution institution NN cord-010119-t1x9gknd 12076 26 . . . cord-010119-t1x9gknd 12077 1 Future future JJ cord-010119-t1x9gknd 12077 2 strategies strategy NNS cord-010119-t1x9gknd 12077 3 for for IN cord-010119-t1x9gknd 12077 4 avoiding avoid VBG cord-010119-t1x9gknd 12077 5 similar similar JJ cord-010119-t1x9gknd 12077 6 situations situation NNS cord-010119-t1x9gknd 12077 7 include include VBP cord-010119-t1x9gknd 12077 8 expanding expand VBG cord-010119-t1x9gknd 12077 9 our -PRON- PRP$ cord-010119-t1x9gknd 12077 10 national national JJ cord-010119-t1x9gknd 12077 11 HIE hie NN cord-010119-t1x9gknd 12077 12 for for IN cord-010119-t1x9gknd 12077 13 critical critical JJ cord-010119-t1x9gknd 12077 14 information information NN cord-010119-t1x9gknd 12077 15 such such JJ cord-010119-t1x9gknd 12077 16 as as IN cord-010119-t1x9gknd 12077 17 BBTM BBTM NNP cord-010119-t1x9gknd 12077 18 history history NN cord-010119-t1x9gknd 12077 19 and and CC cord-010119-t1x9gknd 12077 20 allergy allergy NN cord-010119-t1x9gknd 12077 21 history history NN cord-010119-t1x9gknd 12077 22 and and CC cord-010119-t1x9gknd 12077 23 expanding expand VBG cord-010119-t1x9gknd 12077 24 use use NN cord-010119-t1x9gknd 12077 25 of of IN cord-010119-t1x9gknd 12077 26 wallet wallet NN cord-010119-t1x9gknd 12077 27 - - HYPH cord-010119-t1x9gknd 12077 28 size size NN cord-010119-t1x9gknd 12077 29 patient patient NN cord-010119-t1x9gknd 12077 30 identification identification NN cord-010119-t1x9gknd 12077 31 cards card NNS cord-010119-t1x9gknd 12077 32 with with IN cord-010119-t1x9gknd 12077 33 RhIg RhIg NNP cord-010119-t1x9gknd 12077 34 and and CC cord-010119-t1x9gknd 12077 35 alloantibody alloantibody NN cord-010119-t1x9gknd 12077 36 histories history NNS cord-010119-t1x9gknd 12077 37 . . . cord-010119-t1x9gknd 12078 1 Auditing Auditing NNP cord-010119-t1x9gknd 12078 2 Massive Massive NNP cord-010119-t1x9gknd 12078 3 Transfusion Transfusion NNP cord-010119-t1x9gknd 12078 4 Protocol Protocol NNP cord-010119-t1x9gknd 12079 1 Colleen Colleen NNP cord-010119-t1x9gknd 12079 2 A. a. NN cord-010119-t1x9gknd 12079 3 Aronson Aronson NNP cord-010119-t1x9gknd 12080 1 * * NFP cord-010119-t1x9gknd 12080 2 1 1 CD cord-010119-t1x9gknd 12080 3 , , , cord-010119-t1x9gknd 12080 4 Elizabeth Elizabeth NNP cord-010119-t1x9gknd 12080 5 Halperin Halperin NNP cord-010119-t1x9gknd 12080 6 2 2 CD cord-010119-t1x9gknd 12080 7 , , , cord-010119-t1x9gknd 12080 8 Sharon Sharon NNP cord-010119-t1x9gknd 12080 9 Breining Breining NNP cord-010119-t1x9gknd 12080 10 2 2 CD cord-010119-t1x9gknd 12080 11 and and CC cord-010119-t1x9gknd 12080 12 Mona Mona NNP cord-010119-t1x9gknd 12080 13 Papari Papari NNP cord-010119-t1x9gknd 12080 14 3 3 CD cord-010119-t1x9gknd 12080 15 . . . cord-010119-t1x9gknd 12081 1 1 1 CD cord-010119-t1x9gknd 12081 2 ACL ACL NNP cord-010119-t1x9gknd 12081 3 Laboratories/ Laboratories/ NNP cord-010119-t1x9gknd 12081 4 Advocate Advocate NNP cord-010119-t1x9gknd 12081 5 Hospitals Hospitals NNPS cord-010119-t1x9gknd 12081 6 , , , cord-010119-t1x9gknd 12081 7 2 2 CD cord-010119-t1x9gknd 12081 8 Advocate Advocate NNP cord-010119-t1x9gknd 12081 9 Health Health NNP cord-010119-t1x9gknd 12081 10 Care Care NNP cord-010119-t1x9gknd 12081 11 , , , cord-010119-t1x9gknd 12081 12 3 3 CD cord-010119-t1x9gknd 12081 13 ITxM ITxM NNP cord-010119-t1x9gknd 12081 14 Background Background NNP cord-010119-t1x9gknd 12081 15 / / SYM cord-010119-t1x9gknd 12081 16 Case Case NNP cord-010119-t1x9gknd 12081 17 Studies Studies NNPS cord-010119-t1x9gknd 12081 18 : : : cord-010119-t1x9gknd 12081 19 A a DT cord-010119-t1x9gknd 12081 20 large large JJ cord-010119-t1x9gknd 12081 21 Midwest Midwest NNP cord-010119-t1x9gknd 12081 22 hospital hospital NN cord-010119-t1x9gknd 12081 23 system system NN cord-010119-t1x9gknd 12081 24 with with IN cord-010119-t1x9gknd 12081 25 5 5 CD cord-010119-t1x9gknd 12081 26 Level level NN cord-010119-t1x9gknd 12081 27 I -PRON- PRP cord-010119-t1x9gknd 12081 28 trauma trauma NN cord-010119-t1x9gknd 12081 29 sites site NNS cord-010119-t1x9gknd 12081 30 evaluated evaluate VBD cord-010119-t1x9gknd 12081 31 how how WRB cord-010119-t1x9gknd 12081 32 to to TO cord-010119-t1x9gknd 12081 33 audit audit VB cord-010119-t1x9gknd 12081 34 the the DT cord-010119-t1x9gknd 12081 35 Massive Massive NNP cord-010119-t1x9gknd 12081 36 Transfusion Transfusion NNP cord-010119-t1x9gknd 12081 37 Protocol Protocol NNP cord-010119-t1x9gknd 12081 38 ( ( -LRB- cord-010119-t1x9gknd 12081 39 MTP MTP NNP cord-010119-t1x9gknd 12081 40 ) ) -RRB- cord-010119-t1x9gknd 12081 41 . . . cord-010119-t1x9gknd 12082 1 The the DT cord-010119-t1x9gknd 12082 2 possibility possibility NN cord-010119-t1x9gknd 12082 3 of of IN cord-010119-t1x9gknd 12082 4 real real JJ cord-010119-t1x9gknd 12082 5 time time NN cord-010119-t1x9gknd 12082 6 audits audits NN cord-010119-t1x9gknd 12082 7 is be VBZ cord-010119-t1x9gknd 12082 8 impractical impractical JJ cord-010119-t1x9gknd 12082 9 due due IN cord-010119-t1x9gknd 12082 10 to to IN cord-010119-t1x9gknd 12082 11 the the DT cord-010119-t1x9gknd 12082 12 unpredictability unpredictability NN cord-010119-t1x9gknd 12082 13 of of IN cord-010119-t1x9gknd 12082 14 these these DT cord-010119-t1x9gknd 12082 15 events event NNS cord-010119-t1x9gknd 12082 16 . . . cord-010119-t1x9gknd 12083 1 A a DT cord-010119-t1x9gknd 12083 2 search search NN cord-010119-t1x9gknd 12083 3 of of IN cord-010119-t1x9gknd 12083 4 the the DT cord-010119-t1x9gknd 12083 5 internet internet NN cord-010119-t1x9gknd 12083 6 found find VBD cord-010119-t1x9gknd 12083 7 an an DT cord-010119-t1x9gknd 12083 8 example example NN cord-010119-t1x9gknd 12083 9 from from IN cord-010119-t1x9gknd 12083 10 New New NNP cord-010119-t1x9gknd 12083 11 Zealand Zealand NNP cord-010119-t1x9gknd 12083 12 for for IN cord-010119-t1x9gknd 12083 13 post post NN cord-010119-t1x9gknd 12083 14 process process NN cord-010119-t1x9gknd 12083 15 evaluation evaluation NN cord-010119-t1x9gknd 12083 16 . . . cord-010119-t1x9gknd 12084 1 This this DT cord-010119-t1x9gknd 12084 2 was be VBD cord-010119-t1x9gknd 12084 3 shared share VBN cord-010119-t1x9gknd 12084 4 with with IN cord-010119-t1x9gknd 12084 5 a a DT cord-010119-t1x9gknd 12084 6 team team NN cord-010119-t1x9gknd 12084 7 as as IN cord-010119-t1x9gknd 12084 8 a a DT cord-010119-t1x9gknd 12084 9 starting starting NN cord-010119-t1x9gknd 12084 10 point point NN cord-010119-t1x9gknd 12084 11 and and CC cord-010119-t1x9gknd 12084 12 then then RB cord-010119-t1x9gknd 12084 13 adjusted adjust VBD cord-010119-t1x9gknd 12084 14 for for IN cord-010119-t1x9gknd 12084 15 system system NN cord-010119-t1x9gknd 12084 16 specific specific JJ cord-010119-t1x9gknd 12084 17 priorities priority NNS cord-010119-t1x9gknd 12084 18 . . . cord-010119-t1x9gknd 12085 1 To to TO cord-010119-t1x9gknd 12085 2 start start VB cord-010119-t1x9gknd 12085 3 the the DT cord-010119-t1x9gknd 12085 4 audit audit NN cord-010119-t1x9gknd 12085 5 , , , cord-010119-t1x9gknd 12085 6 the the DT cord-010119-t1x9gknd 12085 7 initiation initiation NN cord-010119-t1x9gknd 12085 8 of of IN cord-010119-t1x9gknd 12085 9 the the DT cord-010119-t1x9gknd 12085 10 MTP MTP NNP cord-010119-t1x9gknd 12085 11 needed need VBD cord-010119-t1x9gknd 12085 12 to to TO cord-010119-t1x9gknd 12085 13 be be VB cord-010119-t1x9gknd 12085 14 determined determine VBN cord-010119-t1x9gknd 12085 15 as as IN cord-010119-t1x9gknd 12085 16 events event NNS cord-010119-t1x9gknd 12085 17 are be VBP cord-010119-t1x9gknd 12085 18 often often RB cord-010119-t1x9gknd 12085 19 started start VBN cord-010119-t1x9gknd 12085 20 as as IN cord-010119-t1x9gknd 12085 21 a a DT cord-010119-t1x9gknd 12085 22 verbal verbal JJ cord-010119-t1x9gknd 12085 23 request request NN cord-010119-t1x9gknd 12085 24 but but CC cord-010119-t1x9gknd 12085 25 then then RB cord-010119-t1x9gknd 12085 26 followed follow VBD cord-010119-t1x9gknd 12085 27 up up RP cord-010119-t1x9gknd 12085 28 with with IN cord-010119-t1x9gknd 12085 29 either either DT cord-010119-t1x9gknd 12085 30 downtime downtime NN cord-010119-t1x9gknd 12085 31 or or CC cord-010119-t1x9gknd 12085 32 computer computer NN cord-010119-t1x9gknd 12085 33 orders order NNS cord-010119-t1x9gknd 12085 34 . . . cord-010119-t1x9gknd 12086 1 Study Study NNP cord-010119-t1x9gknd 12086 2 Design Design NNP cord-010119-t1x9gknd 12086 3 / / SYM cord-010119-t1x9gknd 12086 4 Method method NN cord-010119-t1x9gknd 12086 5 : : : cord-010119-t1x9gknd 12086 6 The the DT cord-010119-t1x9gknd 12086 7 Transfusion Transfusion NNP cord-010119-t1x9gknd 12086 8 Service Service NNP cord-010119-t1x9gknd 12086 9 ( ( -LRB- cord-010119-t1x9gknd 12086 10 TS TS NNP cord-010119-t1x9gknd 12086 11 ) ) -RRB- cord-010119-t1x9gknd 12086 12 was be VBD cord-010119-t1x9gknd 12086 13 determined determine VBN cord-010119-t1x9gknd 12086 14 to to TO cord-010119-t1x9gknd 12086 15 be be VB cord-010119-t1x9gknd 12086 16 the the DT cord-010119-t1x9gknd 12086 17 source source NN cord-010119-t1x9gknd 12086 18 of of IN cord-010119-t1x9gknd 12086 19 truth truth NN cord-010119-t1x9gknd 12086 20 for for IN cord-010119-t1x9gknd 12086 21 all all DT cord-010119-t1x9gknd 12086 22 of of IN cord-010119-t1x9gknd 12086 23 the the DT cord-010119-t1x9gknd 12086 24 MTP MTP NNP cord-010119-t1x9gknd 12086 25 events event NNS cord-010119-t1x9gknd 12086 26 . . . cord-010119-t1x9gknd 12087 1 A a DT cord-010119-t1x9gknd 12087 2 tracking tracking NN cord-010119-t1x9gknd 12087 3 sheet sheet NN cord-010119-t1x9gknd 12087 4 was be VBD cord-010119-t1x9gknd 12087 5 created create VBN cord-010119-t1x9gknd 12087 6 to to TO cord-010119-t1x9gknd 12087 7 capture capture VB cord-010119-t1x9gknd 12087 8 the the DT cord-010119-t1x9gknd 12087 9 patient patient NN cord-010119-t1x9gknd 12087 10 demographics demographic NNS cord-010119-t1x9gknd 12087 11 , , , cord-010119-t1x9gknd 12087 12 start start VB cord-010119-t1x9gknd 12087 13 and and CC cord-010119-t1x9gknd 12087 14 stop stop VB cord-010119-t1x9gknd 12087 15 time time NN cord-010119-t1x9gknd 12087 16 , , , cord-010119-t1x9gknd 12087 17 number number NN cord-010119-t1x9gknd 12087 18 and and CC cord-010119-t1x9gknd 12087 19 type type NN cord-010119-t1x9gknd 12087 20 of of IN cord-010119-t1x9gknd 12087 21 products product NNS cord-010119-t1x9gknd 12087 22 issued issue VBN cord-010119-t1x9gknd 12087 23 and and CC cord-010119-t1x9gknd 12087 24 wastage wastage NN cord-010119-t1x9gknd 12087 25 . . . cord-010119-t1x9gknd 12088 1 This this DT cord-010119-t1x9gknd 12088 2 was be VBD cord-010119-t1x9gknd 12088 3 then then RB cord-010119-t1x9gknd 12088 4 passed pass VBN cord-010119-t1x9gknd 12088 5 onto onto IN cord-010119-t1x9gknd 12088 6 nursing nursing NN cord-010119-t1x9gknd 12088 7 quality quality NN cord-010119-t1x9gknd 12088 8 staff staff NN cord-010119-t1x9gknd 12088 9 that that WDT cord-010119-t1x9gknd 12088 10 used use VBD cord-010119-t1x9gknd 12088 11 the the DT cord-010119-t1x9gknd 12088 12 tracking tracking NN cord-010119-t1x9gknd 12088 13 form form NN cord-010119-t1x9gknd 12088 14 and and CC cord-010119-t1x9gknd 12088 15 the the DT cord-010119-t1x9gknd 12088 16 patient patient JJ cord-010119-t1x9gknd 12088 17 chart chart NN cord-010119-t1x9gknd 12088 18 to to TO cord-010119-t1x9gknd 12088 19 enter enter VB cord-010119-t1x9gknd 12088 20 an an DT cord-010119-t1x9gknd 12088 21 event event NN cord-010119-t1x9gknd 12088 22 into into IN cord-010119-t1x9gknd 12088 23 the the DT cord-010119-t1x9gknd 12088 24 error error NN cord-010119-t1x9gknd 12088 25 management management NN cord-010119-t1x9gknd 12088 26 data datum NNS cord-010119-t1x9gknd 12088 27 base base NN cord-010119-t1x9gknd 12088 28 as as IN cord-010119-t1x9gknd 12088 29 a a DT cord-010119-t1x9gknd 12088 30 focused focused JJ cord-010119-t1x9gknd 12088 31 event event NN cord-010119-t1x9gknd 12088 32 . . . cord-010119-t1x9gknd 12089 1 The the DT cord-010119-t1x9gknd 12089 2 focused focused JJ cord-010119-t1x9gknd 12089 3 event event NN cord-010119-t1x9gknd 12089 4 was be VBD cord-010119-t1x9gknd 12089 5 built build VBN cord-010119-t1x9gknd 12089 6 to to TO cord-010119-t1x9gknd 12089 7 include include VB cord-010119-t1x9gknd 12089 8 patient patient JJ cord-010119-t1x9gknd 12089 9 demographics demographic NNS cord-010119-t1x9gknd 12089 10 and and CC cord-010119-t1x9gknd 12089 11 other other JJ cord-010119-t1x9gknd 12089 12 information information NN cord-010119-t1x9gknd 12089 13 from from IN cord-010119-t1x9gknd 12089 14 the the DT cord-010119-t1x9gknd 12089 15 tracking tracking NN cord-010119-t1x9gknd 12089 16 form form NN cord-010119-t1x9gknd 12089 17 as as RB cord-010119-t1x9gknd 12089 18 well well RB cord-010119-t1x9gknd 12089 19 as as IN cord-010119-t1x9gknd 12089 20 where where WRB cord-010119-t1x9gknd 12089 21 the the DT cord-010119-t1x9gknd 12089 22 event event NN cord-010119-t1x9gknd 12089 23 was be VBD cord-010119-t1x9gknd 12089 24 called call VBN cord-010119-t1x9gknd 12089 25 ( ( -LRB- cord-010119-t1x9gknd 12089 26 Surgery surgery NN cord-010119-t1x9gknd 12089 27 ( ( -LRB- cord-010119-t1x9gknd 12089 28 OR OR NNP cord-010119-t1x9gknd 12089 29 ) ) -RRB- cord-010119-t1x9gknd 12089 30 , , , cord-010119-t1x9gknd 12089 31 Emergency emergency NN cord-010119-t1x9gknd 12089 32 ( ( -LRB- cord-010119-t1x9gknd 12089 33 ED ED NNP cord-010119-t1x9gknd 12089 34 ) ) -RRB- cord-010119-t1x9gknd 12089 35 , , , cord-010119-t1x9gknd 12089 36 Labor Labor NNP cord-010119-t1x9gknd 12089 37 and and CC cord-010119-t1x9gknd 12089 38 Delivery Delivery NNP cord-010119-t1x9gknd 12089 39 ( ( -LRB- cord-010119-t1x9gknd 12089 40 L&D L&D NNP cord-010119-t1x9gknd 12089 41 ) ) -RRB- cord-010119-t1x9gknd 12089 42 , , , cord-010119-t1x9gknd 12089 43 etc etc FW cord-010119-t1x9gknd 12089 44 . . . cord-010119-t1x9gknd 12089 45 ) ) -RRB- cord-010119-t1x9gknd 12089 46 , , , cord-010119-t1x9gknd 12089 47 type type NN cord-010119-t1x9gknd 12089 48 of of IN cord-010119-t1x9gknd 12089 49 event event NN cord-010119-t1x9gknd 12089 50 , , , cord-010119-t1x9gknd 12089 51 use use NN cord-010119-t1x9gknd 12089 52 of of IN cord-010119-t1x9gknd 12089 53 tranexamic tranexamic JJ cord-010119-t1x9gknd 12089 54 acid acid NN cord-010119-t1x9gknd 12089 55 ( ( -LRB- cord-010119-t1x9gknd 12089 56 TXA TXA NNP cord-010119-t1x9gknd 12089 57 ) ) -RRB- cord-010119-t1x9gknd 12089 58 , , , cord-010119-t1x9gknd 12089 59 calcium calcium NN cord-010119-t1x9gknd 12089 60 chloride chloride NN cord-010119-t1x9gknd 12089 61 ( ( -LRB- cord-010119-t1x9gknd 12089 62 CaCl CaCl NNP cord-010119-t1x9gknd 12089 63 ) ) -RRB- cord-010119-t1x9gknd 12089 64 , , , cord-010119-t1x9gknd 12089 65 temperature temperature NN cord-010119-t1x9gknd 12089 66 monitoring monitoring NN cord-010119-t1x9gknd 12089 67 and and CC cord-010119-t1x9gknd 12089 68 pre/ pre/ ADD cord-010119-t1x9gknd 12089 69 post post NN cord-010119-t1x9gknd 12089 70 lab lab NN cord-010119-t1x9gknd 12089 71 results result NNS cord-010119-t1x9gknd 12089 72 . . . cord-010119-t1x9gknd 12090 1 A a DT cord-010119-t1x9gknd 12090 2 trial trial NN cord-010119-t1x9gknd 12090 3 was be VBD cord-010119-t1x9gknd 12090 4 started start VBN cord-010119-t1x9gknd 12090 5 and and CC cord-010119-t1x9gknd 12090 6 3 3 CD cord-010119-t1x9gknd 12090 7 months month NNS cord-010119-t1x9gknd 12090 8 of of IN cord-010119-t1x9gknd 12090 9 data datum NNS cord-010119-t1x9gknd 12090 10 were be VBD cord-010119-t1x9gknd 12090 11 evaluated evaluate VBN cord-010119-t1x9gknd 12090 12 that that IN cord-010119-t1x9gknd 12090 13 contained contain VBN cord-010119-t1x9gknd 12090 14 29 29 CD cord-010119-t1x9gknd 12090 15 events event NNS cord-010119-t1x9gknd 12090 16 . . . cord-010119-t1x9gknd 12091 1 Results/ Results/ . cord-010119-t1x9gknd 12092 1 Finding find VBG cord-010119-t1x9gknd 12093 1 : : : cord-010119-t1x9gknd 12093 2 There there EX cord-010119-t1x9gknd 12093 3 was be VBD cord-010119-t1x9gknd 12093 4 an an DT cord-010119-t1x9gknd 12093 5 equal equal JJ cord-010119-t1x9gknd 12093 6 number number NN cord-010119-t1x9gknd 12093 7 of of IN cord-010119-t1x9gknd 12093 8 events event NNS cord-010119-t1x9gknd 12093 9 that that WDT cord-010119-t1x9gknd 12093 10 were be VBD cord-010119-t1x9gknd 12093 11 initiated initiate VBN cord-010119-t1x9gknd 12093 12 in in IN cord-010119-t1x9gknd 12093 13 the the DT cord-010119-t1x9gknd 12093 14 ED ED NNP cord-010119-t1x9gknd 12093 15 and and CC cord-010119-t1x9gknd 12093 16 the the DT cord-010119-t1x9gknd 12093 17 OR OR NNP cord-010119-t1x9gknd 12093 18 ( ( -LRB- cord-010119-t1x9gknd 12093 19 12 12 CD cord-010119-t1x9gknd 12093 20 ) ) -RRB- cord-010119-t1x9gknd 12093 21 . . . cord-010119-t1x9gknd 12094 1 Male male JJ cord-010119-t1x9gknd 12094 2 patients patient NNS cord-010119-t1x9gknd 12094 3 were be VBD cord-010119-t1x9gknd 12094 4 involved involve VBN cord-010119-t1x9gknd 12094 5 69 69 CD cord-010119-t1x9gknd 12094 6 % % NN cord-010119-t1x9gknd 12094 7 of of IN cord-010119-t1x9gknd 12094 8 the the DT cord-010119-t1x9gknd 12094 9 time time NN cord-010119-t1x9gknd 12094 10 and and CC cord-010119-t1x9gknd 12094 11 31 31 CD cord-010119-t1x9gknd 12094 12 % % NN cord-010119-t1x9gknd 12094 13 of of IN cord-010119-t1x9gknd 12094 14 time time NN cord-010119-t1x9gknd 12094 15 the the DT cord-010119-t1x9gknd 12094 16 patients patient NNS cord-010119-t1x9gknd 12094 17 expired expire VBD cord-010119-t1x9gknd 12094 18 . . . cord-010119-t1x9gknd 12095 1 Trauma trauma NN cord-010119-t1x9gknd 12095 2 of of IN cord-010119-t1x9gknd 12095 3 some some DT cord-010119-t1x9gknd 12095 4 type type NN cord-010119-t1x9gknd 12095 5 was be VBD cord-010119-t1x9gknd 12095 6 the the DT cord-010119-t1x9gknd 12095 7 majority majority NN cord-010119-t1x9gknd 12095 8 of of IN cord-010119-t1x9gknd 12095 9 the the DT cord-010119-t1x9gknd 12095 10 cause cause NN cord-010119-t1x9gknd 12095 11 but but CC cord-010119-t1x9gknd 12096 1 13.8 13.8 CD cord-010119-t1x9gknd 12096 2 % % NN cord-010119-t1x9gknd 12096 3 of of IN cord-010119-t1x9gknd 12096 4 the the DT cord-010119-t1x9gknd 12096 5 cases case NNS cord-010119-t1x9gknd 12096 6 involved involve VBN cord-010119-t1x9gknd 12096 7 GI GI NNP cord-010119-t1x9gknd 12096 8 Bleed Bleed NNP cord-010119-t1x9gknd 12096 9 and and CC cord-010119-t1x9gknd 12096 10 only only RB cord-010119-t1x9gknd 12096 11 6.9 6.9 CD cord-010119-t1x9gknd 12096 12 % % NN cord-010119-t1x9gknd 12096 13 were be VBD cord-010119-t1x9gknd 12096 14 obstetric obstetric JJ cord-010119-t1x9gknd 12096 15 cases case NNS cord-010119-t1x9gknd 12096 16 ( ( -LRB- cord-010119-t1x9gknd 12096 17 see see VB cord-010119-t1x9gknd 12096 18 chart chart NN cord-010119-t1x9gknd 12096 19 ) ) -RRB- cord-010119-t1x9gknd 12096 20 . . . cord-010119-t1x9gknd 12097 1 The the DT cord-010119-t1x9gknd 12097 2 lowest low JJS cord-010119-t1x9gknd 12097 3 hemoglobin hemoglobin NN cord-010119-t1x9gknd 12097 4 ( ( -LRB- cord-010119-t1x9gknd 12097 5 Hgb Hgb NNP cord-010119-t1x9gknd 12097 6 ) ) -RRB- cord-010119-t1x9gknd 12097 7 was be VBD cord-010119-t1x9gknd 12097 8 found find VBN cord-010119-t1x9gknd 12097 9 to to IN cord-010119-t1x9gknd 12097 10 average average VB cord-010119-t1x9gknd 12097 11 7.1 7.1 CD cord-010119-t1x9gknd 12097 12 with with IN cord-010119-t1x9gknd 12097 13 the the DT cord-010119-t1x9gknd 12097 14 post post NN cord-010119-t1x9gknd 12097 15 Hgb Hgb NNP cord-010119-t1x9gknd 12097 16 average average NN cord-010119-t1x9gknd 12097 17 of of IN cord-010119-t1x9gknd 12097 18 9.7 9.7 CD cord-010119-t1x9gknd 12097 19 . . . cord-010119-t1x9gknd 12098 1 Ratios ratio NNS cord-010119-t1x9gknd 12098 2 of of IN cord-010119-t1x9gknd 12098 3 1:1 1:1 CD cord-010119-t1x9gknd 12098 4 for for IN cord-010119-t1x9gknd 12098 5 Red Red NNP cord-010119-t1x9gknd 12098 6 Blood Blood NNP cord-010119-t1x9gknd 12098 7 Cells Cells NNPS cord-010119-t1x9gknd 12098 8 ( ( -LRB- cord-010119-t1x9gknd 12098 9 RBC RBC NNP cord-010119-t1x9gknd 12098 10 ) ) -RRB- cord-010119-t1x9gknd 12098 11 to to TO cord-010119-t1x9gknd 12098 12 plasma plasma VB cord-010119-t1x9gknd 12098 13 as as RB cord-010119-t1x9gknd 12098 14 well well RB cord-010119-t1x9gknd 12098 15 as as IN cord-010119-t1x9gknd 12098 16 RBC RBC NNP cord-010119-t1x9gknd 12098 17 to to IN cord-010119-t1x9gknd 12098 18 Platelets platelet NNS cord-010119-t1x9gknd 12098 19 ( ( -LRB- cord-010119-t1x9gknd 12098 20 PLT PLT NNP cord-010119-t1x9gknd 12098 21 ) ) -RRB- cord-010119-t1x9gknd 12098 22 and and CC cord-010119-t1x9gknd 12098 23 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 12098 24 ( ( -LRB- cord-010119-t1x9gknd 12098 25 CRYO CRYO NNP cord-010119-t1x9gknd 12098 26 ) ) -RRB- cord-010119-t1x9gknd 12098 27 were be VBD cord-010119-t1x9gknd 12098 28 also also RB cord-010119-t1x9gknd 12098 29 determined determine VBN cord-010119-t1x9gknd 12098 30 with with IN cord-010119-t1x9gknd 12098 31 a a DT cord-010119-t1x9gknd 12098 32 target target NN cord-010119-t1x9gknd 12098 33 of of IN cord-010119-t1x9gknd 12098 34 4:1 4:1 CD cord-010119-t1x9gknd 12098 35 . . . cord-010119-t1x9gknd 12099 1 It -PRON- PRP cord-010119-t1x9gknd 12099 2 was be VBD cord-010119-t1x9gknd 12099 3 found find VBN cord-010119-t1x9gknd 12099 4 that that IN cord-010119-t1x9gknd 12099 5 the the DT cord-010119-t1x9gknd 12099 6 RBC RBC NNP cord-010119-t1x9gknd 12099 7 : : : cord-010119-t1x9gknd 12099 8 plasma plasma NN cord-010119-t1x9gknd 12099 9 was be VBD cord-010119-t1x9gknd 12099 10 1.9:1 1.9:1 CD cord-010119-t1x9gknd 12099 11 , , , cord-010119-t1x9gknd 12099 12 RBC RBC NNP cord-010119-t1x9gknd 12099 13 : : : cord-010119-t1x9gknd 12100 1 PLT PLT NNP cord-010119-t1x9gknd 12100 2 was be VBD cord-010119-t1x9gknd 12100 3 5.9:1 5.9:1 NNP cord-010119-t1x9gknd 12100 4 and and CC cord-010119-t1x9gknd 12100 5 RBC RBC NNP cord-010119-t1x9gknd 12100 6 to to IN cord-010119-t1x9gknd 12100 7 CRYO CRYO NNP cord-010119-t1x9gknd 12100 8 was be VBD cord-010119-t1x9gknd 12100 9 7.4:1 7.4:1 RB cord-010119-t1x9gknd 12100 10 . . . cord-010119-t1x9gknd 12101 1 Use Use NNP cord-010119-t1x9gknd 12101 2 of of IN cord-010119-t1x9gknd 12101 3 TXA TXA NNP cord-010119-t1x9gknd 12101 4 was be VBD cord-010119-t1x9gknd 12101 5 only only RB cord-010119-t1x9gknd 12101 6 24.1 24.1 CD cord-010119-t1x9gknd 12101 7 % % NN cord-010119-t1x9gknd 12101 8 and and CC cord-010119-t1x9gknd 12101 9 CaCl CaCl NNP cord-010119-t1x9gknd 12101 10 was be VBD cord-010119-t1x9gknd 12101 11 utilized utilize VBN cord-010119-t1x9gknd 12101 12 in in IN cord-010119-t1x9gknd 12101 13 58.6 58.6 CD cord-010119-t1x9gknd 12101 14 % % NN cord-010119-t1x9gknd 12101 15 of of IN cord-010119-t1x9gknd 12101 16 cases case NNS cord-010119-t1x9gknd 12101 17 . . . cord-010119-t1x9gknd 12102 1 Conclusion conclusion NN cord-010119-t1x9gknd 12102 2 : : : cord-010119-t1x9gknd 12103 1 Although although IN cord-010119-t1x9gknd 12103 2 this this DT cord-010119-t1x9gknd 12103 3 data data NN cord-010119-t1x9gknd 12103 4 is be VBZ cord-010119-t1x9gknd 12103 5 for for IN cord-010119-t1x9gknd 12103 6 a a DT cord-010119-t1x9gknd 12103 7 short short JJ cord-010119-t1x9gknd 12103 8 period period NN cord-010119-t1x9gknd 12103 9 of of IN cord-010119-t1x9gknd 12103 10 time time NN cord-010119-t1x9gknd 12103 11 it -PRON- PRP cord-010119-t1x9gknd 12103 12 has have VBZ cord-010119-t1x9gknd 12103 13 pointed point VBN cord-010119-t1x9gknd 12103 14 out out RP cord-010119-t1x9gknd 12103 15 several several JJ cord-010119-t1x9gknd 12103 16 opportunities opportunity NNS cord-010119-t1x9gknd 12103 17 for for IN cord-010119-t1x9gknd 12103 18 improvement improvement NN cord-010119-t1x9gknd 12103 19 . . . cord-010119-t1x9gknd 12104 1 The the DT cord-010119-t1x9gknd 12104 2 use use NN cord-010119-t1x9gknd 12104 3 of of IN cord-010119-t1x9gknd 12104 4 MTP MTP NNP cord-010119-t1x9gknd 12104 5 in in IN cord-010119-t1x9gknd 12104 6 GI GI NNP cord-010119-t1x9gknd 12104 7 cases case NNS cord-010119-t1x9gknd 12104 8 was be VBD cord-010119-t1x9gknd 12104 9 not not RB cord-010119-t1x9gknd 12104 10 previously previously RB cord-010119-t1x9gknd 12104 11 understood understand VBN cord-010119-t1x9gknd 12104 12 but but CC cord-010119-t1x9gknd 12104 13 opens open VBZ cord-010119-t1x9gknd 12104 14 up up RP cord-010119-t1x9gknd 12104 15 a a DT cord-010119-t1x9gknd 12104 16 new new JJ cord-010119-t1x9gknd 12104 17 group group NN cord-010119-t1x9gknd 12104 18 of of IN cord-010119-t1x9gknd 12104 19 people people NNS cord-010119-t1x9gknd 12104 20 for for IN cord-010119-t1x9gknd 12104 21 which which WDT cord-010119-t1x9gknd 12104 22 education education NN cord-010119-t1x9gknd 12104 23 and and CC cord-010119-t1x9gknd 12104 24 understanding understanding NN cord-010119-t1x9gknd 12104 25 of of IN cord-010119-t1x9gknd 12104 26 the the DT cord-010119-t1x9gknd 12104 27 MTP MTP NNP cord-010119-t1x9gknd 12104 28 process process NN cord-010119-t1x9gknd 12104 29 is be VBZ cord-010119-t1x9gknd 12104 30 needed need VBN cord-010119-t1x9gknd 12104 31 . . . cord-010119-t1x9gknd 12105 1 The the DT cord-010119-t1x9gknd 12105 2 low low JJ cord-010119-t1x9gknd 12105 3 use use NN cord-010119-t1x9gknd 12105 4 of of IN cord-010119-t1x9gknd 12105 5 TXA TXA NNP cord-010119-t1x9gknd 12105 6 needs need VBZ cord-010119-t1x9gknd 12105 7 to to TO cord-010119-t1x9gknd 12105 8 be be VB cord-010119-t1x9gknd 12105 9 evaluated evaluate VBN cord-010119-t1x9gknd 12105 10 and and CC cord-010119-t1x9gknd 12105 11 already already RB cord-010119-t1x9gknd 12105 12 has have VBZ cord-010119-t1x9gknd 12105 13 started start VBN cord-010119-t1x9gknd 12105 14 conversations conversation NNS cord-010119-t1x9gknd 12105 15 about about IN cord-010119-t1x9gknd 12105 16 how how WRB cord-010119-t1x9gknd 12105 17 this this DT cord-010119-t1x9gknd 12105 18 drug drug NN cord-010119-t1x9gknd 12105 19 should should MD cord-010119-t1x9gknd 12105 20 be be VB cord-010119-t1x9gknd 12105 21 stored store VBN cord-010119-t1x9gknd 12105 22 and and CC cord-010119-t1x9gknd 12105 23 accessed access VBN cord-010119-t1x9gknd 12105 24 for for IN cord-010119-t1x9gknd 12105 25 the the DT cord-010119-t1x9gknd 12105 26 MTP MTP NNP cord-010119-t1x9gknd 12105 27 process process NN cord-010119-t1x9gknd 12105 28 . . . cord-010119-t1x9gknd 12106 1 The the DT cord-010119-t1x9gknd 12106 2 product product NN cord-010119-t1x9gknd 12106 3 ratio ratio NN cord-010119-t1x9gknd 12106 4 numbers number NNS cord-010119-t1x9gknd 12106 5 were be VBD cord-010119-t1x9gknd 12106 6 suspected suspect VBN cord-010119-t1x9gknd 12106 7 of of IN cord-010119-t1x9gknd 12106 8 being be VBG cord-010119-t1x9gknd 12106 9 off off RP cord-010119-t1x9gknd 12107 1 but but CC cord-010119-t1x9gknd 12107 2 now now RB cord-010119-t1x9gknd 12107 3 that that IN cord-010119-t1x9gknd 12107 4 data data NN cord-010119-t1x9gknd 12107 5 is be VBZ cord-010119-t1x9gknd 12107 6 available available JJ cord-010119-t1x9gknd 12108 1 , , , cord-010119-t1x9gknd 12108 2 it -PRON- PRP cord-010119-t1x9gknd 12108 3 is be VBZ cord-010119-t1x9gknd 12108 4 much much RB cord-010119-t1x9gknd 12108 5 easier easy JJR cord-010119-t1x9gknd 12108 6 to to TO cord-010119-t1x9gknd 12108 7 speak speak VB cord-010119-t1x9gknd 12108 8 to to IN cord-010119-t1x9gknd 12108 9 this this DT cord-010119-t1x9gknd 12108 10 issue issue NN cord-010119-t1x9gknd 12108 11 and and CC cord-010119-t1x9gknd 12108 12 look look VB cord-010119-t1x9gknd 12108 13 for for IN cord-010119-t1x9gknd 12108 14 improvement improvement NN cord-010119-t1x9gknd 12108 15 . . . cord-010119-t1x9gknd 12109 1 The the DT cord-010119-t1x9gknd 12109 2 process process NN cord-010119-t1x9gknd 12109 3 will will MD cord-010119-t1x9gknd 12109 4 now now RB cord-010119-t1x9gknd 12109 5 be be VB cord-010119-t1x9gknd 12109 6 expanded expand VBN cord-010119-t1x9gknd 12109 7 to to IN cord-010119-t1x9gknd 12109 8 the the DT cord-010119-t1x9gknd 12109 9 Level Level NNP cord-010119-t1x9gknd 12109 10 II II NNP cord-010119-t1x9gknd 12109 11 trauma trauma NN cord-010119-t1x9gknd 12109 12 sites site NNS cord-010119-t1x9gknd 12109 13 in in IN cord-010119-t1x9gknd 12109 14 the the DT cord-010119-t1x9gknd 12109 15 system system NN cord-010119-t1x9gknd 12109 16 and and CC cord-010119-t1x9gknd 12109 17 routine routine JJ cord-010119-t1x9gknd 12109 18 evaluation evaluation NN cord-010119-t1x9gknd 12109 19 will will MD cord-010119-t1x9gknd 12109 20 be be VB cord-010119-t1x9gknd 12109 21 shared share VBN cord-010119-t1x9gknd 12109 22 with with IN cord-010119-t1x9gknd 12109 23 all all DT cord-010119-t1x9gknd 12109 24 sites site NNS cord-010119-t1x9gknd 12109 25 . . . cord-010119-t1x9gknd 12110 1 Automated Automated NNP cord-010119-t1x9gknd 12110 2 Report Report NNP cord-010119-t1x9gknd 12110 3 Significantly significantly RB cord-010119-t1x9gknd 12110 4 Reduces reduce VBZ cord-010119-t1x9gknd 12110 5 Turnaround Turnaround NNP cord-010119-t1x9gknd 12110 6 Time time NN cord-010119-t1x9gknd 12110 7 for for IN cord-010119-t1x9gknd 12110 8 RBC RBC NNP cord-010119-t1x9gknd 12110 9 Antibody Antibody NNP cord-010119-t1x9gknd 12110 10 Alert Alert NNP cord-010119-t1x9gknd 12111 1 Jessica Jessica NNP cord-010119-t1x9gknd 12111 2 L L NNP cord-010119-t1x9gknd 12111 3 Dillon Dillon NNP cord-010119-t1x9gknd 12112 1 * * NFP cord-010119-t1x9gknd 12112 2 1 1 CD cord-010119-t1x9gknd 12112 3 , , , cord-010119-t1x9gknd 12112 4 Jody Jody NNP cord-010119-t1x9gknd 12112 5 A A NNP cord-010119-t1x9gknd 12112 6 Barna Barna NNP cord-010119-t1x9gknd 12112 7 1 1 CD cord-010119-t1x9gknd 12112 8 , , , cord-010119-t1x9gknd 12112 9 Donald Donald NNP cord-010119-t1x9gknd 12112 10 E E NNP cord-010119-t1x9gknd 12112 11 Ulinski Ulinski NNP cord-010119-t1x9gknd 12112 12 1 1 CD cord-010119-t1x9gknd 12112 13 and and CC cord-010119-t1x9gknd 12112 14 Nancy Nancy NNP cord-010119-t1x9gknd 12112 15 M. M. NNP cord-010119-t1x9gknd 12112 16 Dunbar Dunbar NNP cord-010119-t1x9gknd 12112 17 2 2 CD cord-010119-t1x9gknd 12112 18 . . . cord-010119-t1x9gknd 12112 19 1 1 CD cord-010119-t1x9gknd 12113 1 Dartmouth Dartmouth NNP cord-010119-t1x9gknd 12113 2 Hitchcock Hitchcock NNP cord-010119-t1x9gknd 12113 3 Medical Medical NNP cord-010119-t1x9gknd 12113 4 Center Center NNP cord-010119-t1x9gknd 12113 5 , , , cord-010119-t1x9gknd 12113 6 2 2 CD cord-010119-t1x9gknd 12113 7 Dartmouth Dartmouth NNP cord-010119-t1x9gknd 12113 8 - - HYPH cord-010119-t1x9gknd 12113 9 Hitchcock Hitchcock NNP cord-010119-t1x9gknd 12113 10 Medical Medical NNP cord-010119-t1x9gknd 12113 11 Center Center NNP cord-010119-t1x9gknd 12113 12 Background Background NNP cord-010119-t1x9gknd 12113 13 / / SYM cord-010119-t1x9gknd 12113 14 Case Case NNP cord-010119-t1x9gknd 12113 15 Studies Studies NNPS cord-010119-t1x9gknd 12113 16 : : : cord-010119-t1x9gknd 12113 17 Clinically clinically RB cord-010119-t1x9gknd 12113 18 significant significant JJ cord-010119-t1x9gknd 12113 19 antibodies antibody NNS cord-010119-t1x9gknd 12113 20 should should MD cord-010119-t1x9gknd 12113 21 be be VB cord-010119-t1x9gknd 12113 22 promptly promptly RB cord-010119-t1x9gknd 12113 23 and and CC cord-010119-t1x9gknd 12113 24 clearly clearly RB cord-010119-t1x9gknd 12113 25 communicated communicate VBN cord-010119-t1x9gknd 12113 26 to to IN cord-010119-t1x9gknd 12113 27 the the DT cord-010119-t1x9gknd 12113 28 patients patient NNS cord-010119-t1x9gknd 12113 29 ' ' POS cord-010119-t1x9gknd 12113 30 healthcare healthcare NN cord-010119-t1x9gknd 12113 31 team team NN cord-010119-t1x9gknd 12113 32 to to TO cord-010119-t1x9gknd 12113 33 avoid avoid VB cord-010119-t1x9gknd 12113 34 potential potential JJ cord-010119-t1x9gknd 12113 35 transfusion transfusion NN cord-010119-t1x9gknd 12113 36 delays delay NNS cord-010119-t1x9gknd 12113 37 in in IN cord-010119-t1x9gknd 12113 38 blood blood NN cord-010119-t1x9gknd 12113 39 availability availability NN cord-010119-t1x9gknd 12113 40 or or CC cord-010119-t1x9gknd 12113 41 complications complication NNS cord-010119-t1x9gknd 12113 42 of of IN cord-010119-t1x9gknd 12113 43 incompatible incompatible JJ cord-010119-t1x9gknd 12113 44 transfusion transfusion NN cord-010119-t1x9gknd 12113 45 . . . cord-010119-t1x9gknd 12114 1 At at IN cord-010119-t1x9gknd 12114 2 our -PRON- PRP$ cord-010119-t1x9gknd 12114 3 institution institution NN cord-010119-t1x9gknd 12114 4 , , , cord-010119-t1x9gknd 12114 5 all all DT cord-010119-t1x9gknd 12114 6 newly newly RB cord-010119-t1x9gknd 12114 7 identified identify VBN cord-010119-t1x9gknd 12114 8 clinically clinically RB cord-010119-t1x9gknd 12114 9 significant significant JJ cord-010119-t1x9gknd 12114 10 antibodies antibody NNS cord-010119-t1x9gknd 12114 11 are be VBP cord-010119-t1x9gknd 12114 12 immediately immediately RB cord-010119-t1x9gknd 12114 13 resulted result VBN cord-010119-t1x9gknd 12114 14 in in IN cord-010119-t1x9gknd 12114 15 the the DT cord-010119-t1x9gknd 12114 16 electronic electronic JJ cord-010119-t1x9gknd 12114 17 medical medical JJ cord-010119-t1x9gknd 12114 18 record record NN cord-010119-t1x9gknd 12114 19 ( ( -LRB- cord-010119-t1x9gknd 12114 20 EMR EMR NNP cord-010119-t1x9gknd 12114 21 ) ) -RRB- cord-010119-t1x9gknd 12114 22 . . . cord-010119-t1x9gknd 12115 1 An an DT cord-010119-t1x9gknd 12115 2 interpretative interpretative JJ cord-010119-t1x9gknd 12115 3 comment comment NN cord-010119-t1x9gknd 12115 4 is be VBZ cord-010119-t1x9gknd 12115 5 also also RB cord-010119-t1x9gknd 12115 6 entered enter VBN cord-010119-t1x9gknd 12115 7 by by IN cord-010119-t1x9gknd 12115 8 the the DT cord-010119-t1x9gknd 12115 9 Transfusion Transfusion NNP cord-010119-t1x9gknd 12115 10 Medicine Medicine NNP cord-010119-t1x9gknd 12115 11 Service Service NNP cord-010119-t1x9gknd 12115 12 ( ( -LRB- cord-010119-t1x9gknd 12115 13 TMS TMS NNP cord-010119-t1x9gknd 12115 14 ) ) -RRB- cord-010119-t1x9gknd 12115 15 Physician Physician NNP cord-010119-t1x9gknd 12115 16 after after IN cord-010119-t1x9gknd 12115 17 the the DT cord-010119-t1x9gknd 12115 18 antibody antibody NN cord-010119-t1x9gknd 12115 19 work work NN cord-010119-t1x9gknd 12115 20 - - HYPH cord-010119-t1x9gknd 12115 21 up up NN cord-010119-t1x9gknd 12115 22 has have VBZ cord-010119-t1x9gknd 12115 23 been be VBN cord-010119-t1x9gknd 12115 24 reviewed review VBN cord-010119-t1x9gknd 12115 25 ( ( -LRB- cord-010119-t1x9gknd 12115 26 this this DT cord-010119-t1x9gknd 12115 27 may may MD cord-010119-t1x9gknd 12115 28 be be VB cord-010119-t1x9gknd 12115 29 up up IN cord-010119-t1x9gknd 12115 30 to to TO cord-010119-t1x9gknd 12115 31 2 2 CD cord-010119-t1x9gknd 12115 32 weeks week NNS cord-010119-t1x9gknd 12115 33 after after IN cord-010119-t1x9gknd 12115 34 the the DT cord-010119-t1x9gknd 12115 35 antibody antibody NN cord-010119-t1x9gknd 12115 36 is be VBZ cord-010119-t1x9gknd 12115 37 identified identify VBN cord-010119-t1x9gknd 12115 38 ) ) -RRB- cord-010119-t1x9gknd 12115 39 . . . cord-010119-t1x9gknd 12116 1 This this DT cord-010119-t1x9gknd 12116 2 comment comment NN cord-010119-t1x9gknd 12116 3 describes describe VBZ cord-010119-t1x9gknd 12116 4 the the DT cord-010119-t1x9gknd 12116 5 antibody(ies antibody(ie NNS cord-010119-t1x9gknd 12116 6 ) ) -RRB- cord-010119-t1x9gknd 12116 7 identified identify VBN cord-010119-t1x9gknd 12116 8 , , , cord-010119-t1x9gknd 12116 9 indicates indicate VBZ cord-010119-t1x9gknd 12116 10 the the DT cord-010119-t1x9gknd 12116 11 need need NN cord-010119-t1x9gknd 12116 12 for for IN cord-010119-t1x9gknd 12116 13 crossmatch crossmatch NN cord-010119-t1x9gknd 12116 14 compatible compatible JJ cord-010119-t1x9gknd 12116 15 blood blood NN cord-010119-t1x9gknd 12116 16 and and CC cord-010119-t1x9gknd 12116 17 alerts alert VBZ cord-010119-t1x9gknd 12116 18 clinicians clinician NNS cord-010119-t1x9gknd 12116 19 of of IN cord-010119-t1x9gknd 12116 20 possible possible JJ cord-010119-t1x9gknd 12116 21 delays delay NNS cord-010119-t1x9gknd 12116 22 in in IN cord-010119-t1x9gknd 12116 23 providing provide VBG cord-010119-t1x9gknd 12116 24 crossmatched crossmatched JJ cord-010119-t1x9gknd 12116 25 units unit NNS cord-010119-t1x9gknd 12116 26 . . . cord-010119-t1x9gknd 12117 1 Since since IN cord-010119-t1x9gknd 12117 2 clinicians clinician NNS cord-010119-t1x9gknd 12117 3 may may MD cord-010119-t1x9gknd 12117 4 not not RB cord-010119-t1x9gknd 12117 5 always always RB cord-010119-t1x9gknd 12117 6 review review VB cord-010119-t1x9gknd 12117 7 these these DT cord-010119-t1x9gknd 12117 8 results result NNS cord-010119-t1x9gknd 12117 9 , , , cord-010119-t1x9gknd 12117 10 the the DT cord-010119-t1x9gknd 12117 11 TMS TMS NNP cord-010119-t1x9gknd 12117 12 Physician Physician NNP cord-010119-t1x9gknd 12117 13 also also RB cord-010119-t1x9gknd 12117 14 simultaneously simultaneously RB cord-010119-t1x9gknd 12117 15 adds add VBZ cord-010119-t1x9gknd 12117 16 an an DT cord-010119-t1x9gknd 12117 17 " " `` cord-010119-t1x9gknd 12117 18 Allergy allergy NN cord-010119-t1x9gknd 12117 19 to to IN cord-010119-t1x9gknd 12117 20 Red Red NNP cord-010119-t1x9gknd 12117 21 Blood Blood NNP cord-010119-t1x9gknd 12117 22 Cells Cells NNPS cord-010119-t1x9gknd 12117 23 " " '' cord-010119-t1x9gknd 12117 24 alert alert JJ cord-010119-t1x9gknd 12117 25 in in IN cord-010119-t1x9gknd 12117 26 the the DT cord-010119-t1x9gknd 12117 27 patient patient NN cord-010119-t1x9gknd 12117 28 EMR EMR NNP cord-010119-t1x9gknd 12117 29 at at IN cord-010119-t1x9gknd 12117 30 the the DT cord-010119-t1x9gknd 12117 31 time time NN cord-010119-t1x9gknd 12117 32 the the DT cord-010119-t1x9gknd 12117 33 interpretive interpretive JJ cord-010119-t1x9gknd 12117 34 comment comment NN cord-010119-t1x9gknd 12117 35 is be VBZ cord-010119-t1x9gknd 12117 36 entered enter VBN cord-010119-t1x9gknd 12117 37 . . . cord-010119-t1x9gknd 12118 1 Study Study NNP cord-010119-t1x9gknd 12118 2 Design Design NNP cord-010119-t1x9gknd 12118 3 / / SYM cord-010119-t1x9gknd 12118 4 Methods method NNS cord-010119-t1x9gknd 12118 5 : : : cord-010119-t1x9gknd 12118 6 In in IN cord-010119-t1x9gknd 12118 7 July July NNP cord-010119-t1x9gknd 12118 8 2016 2016 CD cord-010119-t1x9gknd 12118 9 , , , cord-010119-t1x9gknd 12118 10 we -PRON- PRP cord-010119-t1x9gknd 12118 11 implemented implement VBD cord-010119-t1x9gknd 12118 12 an an DT cord-010119-t1x9gknd 12118 13 automated automated JJ cord-010119-t1x9gknd 12118 14 report report NN cord-010119-t1x9gknd 12118 15 to to TO cord-010119-t1x9gknd 12118 16 reduce reduce VB cord-010119-t1x9gknd 12118 17 the the DT cord-010119-t1x9gknd 12118 18 turnaround turnaround NN cord-010119-t1x9gknd 12118 19 time time NN cord-010119-t1x9gknd 12118 20 ( ( -LRB- cord-010119-t1x9gknd 12118 21 TAT tat NN cord-010119-t1x9gknd 12118 22 ) ) -RRB- cord-010119-t1x9gknd 12118 23 for for IN cord-010119-t1x9gknd 12118 24 entry entry NN cord-010119-t1x9gknd 12118 25 of of IN cord-010119-t1x9gknd 12118 26 the the DT cord-010119-t1x9gknd 12118 27 allergy allergy NN cord-010119-t1x9gknd 12118 28 alert alert NN cord-010119-t1x9gknd 12118 29 . . . cord-010119-t1x9gknd 12119 1 The the DT cord-010119-t1x9gknd 12119 2 report report NN cord-010119-t1x9gknd 12119 3 contains contain VBZ cord-010119-t1x9gknd 12119 4 all all DT cord-010119-t1x9gknd 12119 5 detected detect VBN cord-010119-t1x9gknd 12119 6 red red JJ cord-010119-t1x9gknd 12119 7 cell cell NN cord-010119-t1x9gknd 12119 8 antibodies antibody NNS cord-010119-t1x9gknd 12119 9 in in IN cord-010119-t1x9gknd 12119 10 the the DT cord-010119-t1x9gknd 12119 11 prior prior JJ cord-010119-t1x9gknd 12119 12 24 24 CD cord-010119-t1x9gknd 12119 13 hours hour NNS cord-010119-t1x9gknd 12119 14 and and CC cord-010119-t1x9gknd 12119 15 is be VBZ cord-010119-t1x9gknd 12119 16 provided provide VBN cord-010119-t1x9gknd 12119 17 to to IN cord-010119-t1x9gknd 12119 18 the the DT cord-010119-t1x9gknd 12119 19 TMS TMS NNP cord-010119-t1x9gknd 12119 20 Physician Physician NNP cord-010119-t1x9gknd 12119 21 during during IN cord-010119-t1x9gknd 12119 22 daily daily JJ cord-010119-t1x9gknd 12119 23 morning morning NN cord-010119-t1x9gknd 12119 24 rounds round NNS cord-010119-t1x9gknd 12119 25 ( ( -LRB- cord-010119-t1x9gknd 12119 26 Monday Monday NNP cord-010119-t1x9gknd 12119 27 through through IN cord-010119-t1x9gknd 12119 28 Friday Friday NNP cord-010119-t1x9gknd 12119 29 ) ) -RRB- cord-010119-t1x9gknd 12119 30 for for IN cord-010119-t1x9gknd 12119 31 manual manual JJ cord-010119-t1x9gknd 12119 32 entry entry NN cord-010119-t1x9gknd 12119 33 of of IN cord-010119-t1x9gknd 12119 34 allergy allergy NN cord-010119-t1x9gknd 12119 35 alerts alert NNS cord-010119-t1x9gknd 12119 36 . . . cord-010119-t1x9gknd 12120 1 This this DT cord-010119-t1x9gknd 12120 2 study study NN cord-010119-t1x9gknd 12120 3 describes describe VBZ cord-010119-t1x9gknd 12120 4 a a DT cord-010119-t1x9gknd 12120 5 three three CD cord-010119-t1x9gknd 12120 6 month month NN cord-010119-t1x9gknd 12120 7 comparison comparison NN cord-010119-t1x9gknd 12120 8 both both CC cord-010119-t1x9gknd 12120 9 before before IN cord-010119-t1x9gknd 12120 10 and and CC cord-010119-t1x9gknd 12120 11 after after IN cord-010119-t1x9gknd 12120 12 the the DT cord-010119-t1x9gknd 12120 13 automated automated JJ cord-010119-t1x9gknd 12120 14 report report NN cord-010119-t1x9gknd 12120 15 intervention intervention NN cord-010119-t1x9gknd 12120 16 , , , cord-010119-t1x9gknd 12120 17 to to TO cord-010119-t1x9gknd 12120 18 evaluate evaluate VB cord-010119-t1x9gknd 12120 19 the the DT cord-010119-t1x9gknd 12120 20 TAT tat NN cord-010119-t1x9gknd 12120 21 for for IN cord-010119-t1x9gknd 12120 22 allergy allergy NN cord-010119-t1x9gknd 12120 23 alert alert NN cord-010119-t1x9gknd 12120 24 entry entry NN cord-010119-t1x9gknd 12120 25 into into IN cord-010119-t1x9gknd 12120 26 the the DT cord-010119-t1x9gknd 12120 27 EMR EMR NNP cord-010119-t1x9gknd 12120 28 . . . cord-010119-t1x9gknd 12121 1 Age age NN cord-010119-t1x9gknd 12121 2 ( ( -LRB- cord-010119-t1x9gknd 12121 3 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 12121 4 Results Results NNPS cord-010119-t1x9gknd 12121 5 / / SYM cord-010119-t1x9gknd 12121 6 Findings finding NNS cord-010119-t1x9gknd 12121 7 : : : cord-010119-t1x9gknd 12122 1 Between between IN cord-010119-t1x9gknd 12122 2 August August NNP cord-010119-t1x9gknd 12122 3 2015 2015 CD cord-010119-t1x9gknd 12122 4 and and CC cord-010119-t1x9gknd 12122 5 November November NNP cord-010119-t1x9gknd 12122 6 2015 2015 CD cord-010119-t1x9gknd 12122 7 ( ( -LRB- cord-010119-t1x9gknd 12122 8 pre pre JJ cord-010119-t1x9gknd 12122 9 - - NN cord-010119-t1x9gknd 12122 10 implementation implementation JJ cord-010119-t1x9gknd 12122 11 ) ) -RRB- cord-010119-t1x9gknd 12122 12 , , , cord-010119-t1x9gknd 12122 13 newly newly RB cord-010119-t1x9gknd 12122 14 identified identify VBN cord-010119-t1x9gknd 12122 15 clinically clinically RB cord-010119-t1x9gknd 12122 16 significant significant JJ cord-010119-t1x9gknd 12122 17 antibodies antibody NNS cord-010119-t1x9gknd 12122 18 were be VBD cord-010119-t1x9gknd 12122 19 resulted result VBN cord-010119-t1x9gknd 12122 20 for for IN cord-010119-t1x9gknd 12122 21 56 56 CD cord-010119-t1x9gknd 12122 22 patients patient NNS cord-010119-t1x9gknd 12122 23 compared compare VBN cord-010119-t1x9gknd 12122 24 to to IN cord-010119-t1x9gknd 12122 25 51 51 CD cord-010119-t1x9gknd 12122 26 patients patient NNS cord-010119-t1x9gknd 12122 27 between between IN cord-010119-t1x9gknd 12122 28 the the DT cord-010119-t1x9gknd 12122 29 months month NNS cord-010119-t1x9gknd 12122 30 of of IN cord-010119-t1x9gknd 12122 31 August August NNP cord-010119-t1x9gknd 12122 32 2016 2016 CD cord-010119-t1x9gknd 12122 33 and and CC cord-010119-t1x9gknd 12122 34 November November NNP cord-010119-t1x9gknd 12122 35 2016 2016 CD cord-010119-t1x9gknd 12123 1 ( ( -LRB- cord-010119-t1x9gknd 12123 2 post post NN cord-010119-t1x9gknd 12123 3 - - NN cord-010119-t1x9gknd 12123 4 implementation implementation JJ cord-010119-t1x9gknd 12123 5 ) ) -RRB- cord-010119-t1x9gknd 12123 6 . . . cord-010119-t1x9gknd 12124 1 The the DT cord-010119-t1x9gknd 12124 2 TAT tat NN cord-010119-t1x9gknd 12124 3 for for IN cord-010119-t1x9gknd 12124 4 allergy allergy NN cord-010119-t1x9gknd 12124 5 alert alert NN cord-010119-t1x9gknd 12124 6 entry entry NN cord-010119-t1x9gknd 12124 7 for for IN cord-010119-t1x9gknd 12124 8 both both DT cord-010119-t1x9gknd 12124 9 periods period NNS cord-010119-t1x9gknd 12124 10 is be VBZ cord-010119-t1x9gknd 12124 11 shown show VBN cord-010119-t1x9gknd 12124 12 in in IN cord-010119-t1x9gknd 12124 13 Table Table NNP cord-010119-t1x9gknd 12124 14 1 1 CD cord-010119-t1x9gknd 12124 15 . . . cord-010119-t1x9gknd 12125 1 We -PRON- PRP cord-010119-t1x9gknd 12125 2 observed observe VBD cord-010119-t1x9gknd 12125 3 that that IN cord-010119-t1x9gknd 12125 4 57 57 CD cord-010119-t1x9gknd 12125 5 % % NN cord-010119-t1x9gknd 12125 6 of of IN cord-010119-t1x9gknd 12125 7 allergy allergy NN cord-010119-t1x9gknd 12125 8 comments comment NNS cord-010119-t1x9gknd 12125 9 were be VBD cord-010119-t1x9gknd 12125 10 performed perform VBN cord-010119-t1x9gknd 12125 11 within within IN cord-010119-t1x9gknd 12125 12 24 24 CD cord-010119-t1x9gknd 12125 13 hours hour NNS cord-010119-t1x9gknd 12125 14 in in IN cord-010119-t1x9gknd 12125 15 the the DT cord-010119-t1x9gknd 12125 16 post post NN cord-010119-t1x9gknd 12125 17 - - JJ cord-010119-t1x9gknd 12125 18 implementation implementation JJ cord-010119-t1x9gknd 12125 19 period period NN cord-010119-t1x9gknd 12125 20 versus versus IN cord-010119-t1x9gknd 12125 21 only only RB cord-010119-t1x9gknd 12125 22 30 30 CD cord-010119-t1x9gknd 12125 23 % % NN cord-010119-t1x9gknd 12125 24 pre pre JJ cord-010119-t1x9gknd 12125 25 - - NN cord-010119-t1x9gknd 12125 26 intervention intervention JJ cord-010119-t1x9gknd 12125 27 ( ( -LRB- cord-010119-t1x9gknd 12125 28 p50.0067 p50.0067 NNP cord-010119-t1x9gknd 12125 29 ) ) -RRB- cord-010119-t1x9gknd 12125 30 . . . cord-010119-t1x9gknd 12126 1 Using use VBG cord-010119-t1x9gknd 12126 2 the the DT cord-010119-t1x9gknd 12126 3 new new JJ cord-010119-t1x9gknd 12126 4 process process NN cord-010119-t1x9gknd 12126 5 , , , cord-010119-t1x9gknd 12126 6 nearly nearly RB cord-010119-t1x9gknd 12126 7 all all DT cord-010119-t1x9gknd 12126 8 of of IN cord-010119-t1x9gknd 12126 9 the the DT cord-010119-t1x9gknd 12126 10 alerts alert NNS cord-010119-t1x9gknd 12126 11 were be VBD cord-010119-t1x9gknd 12126 12 entered enter VBN cord-010119-t1x9gknd 12126 13 into into IN cord-010119-t1x9gknd 12126 14 the the DT cord-010119-t1x9gknd 12126 15 EMR EMR NNP cord-010119-t1x9gknd 12126 16 within within IN cord-010119-t1x9gknd 12126 17 72 72 CD cord-010119-t1x9gknd 12126 18 hours hour NNS cord-010119-t1x9gknd 12126 19 of of IN cord-010119-t1x9gknd 12126 20 antibody antibody NN cord-010119-t1x9gknd 12126 21 resulting resulting NN cord-010119-t1x9gknd 12126 22 and and CC cord-010119-t1x9gknd 12126 23 none none NN cord-010119-t1x9gknd 12126 24 of of IN cord-010119-t1x9gknd 12126 25 the the DT cord-010119-t1x9gknd 12126 26 entries entry NNS cord-010119-t1x9gknd 12126 27 were be VBD cord-010119-t1x9gknd 12126 28 missed miss VBN cord-010119-t1x9gknd 12126 29 . . . cord-010119-t1x9gknd 12127 1 Conclusion conclusion NN cord-010119-t1x9gknd 12127 2 : : : cord-010119-t1x9gknd 12127 3 There there EX cord-010119-t1x9gknd 12127 4 was be VBD cord-010119-t1x9gknd 12127 5 a a DT cord-010119-t1x9gknd 12127 6 significant significant JJ cord-010119-t1x9gknd 12127 7 improvement improvement NN cord-010119-t1x9gknd 12127 8 in in IN cord-010119-t1x9gknd 12127 9 the the DT cord-010119-t1x9gknd 12127 10 TAT tat NN cord-010119-t1x9gknd 12127 11 for for IN cord-010119-t1x9gknd 12127 12 allergy allergy NN cord-010119-t1x9gknd 12127 13 comment comment NN cord-010119-t1x9gknd 12127 14 entry entry NN cord-010119-t1x9gknd 12127 15 following follow VBG cord-010119-t1x9gknd 12127 16 implementation implementation NN cord-010119-t1x9gknd 12127 17 of of IN cord-010119-t1x9gknd 12127 18 an an DT cord-010119-t1x9gknd 12127 19 automated automated JJ cord-010119-t1x9gknd 12127 20 report report NN cord-010119-t1x9gknd 12127 21 . . . cord-010119-t1x9gknd 12128 1 This this DT cord-010119-t1x9gknd 12128 2 project project NN cord-010119-t1x9gknd 12128 3 illustrates illustrate VBZ cord-010119-t1x9gknd 12128 4 how how WRB cord-010119-t1x9gknd 12128 5 information information NN cord-010119-t1x9gknd 12128 6 technology technology NN cord-010119-t1x9gknd 12128 7 can can MD cord-010119-t1x9gknd 12128 8 be be VB cord-010119-t1x9gknd 12128 9 leveraged leverage VBN cord-010119-t1x9gknd 12128 10 to to TO cord-010119-t1x9gknd 12128 11 facilitate facilitate VB cord-010119-t1x9gknd 12128 12 timely timely JJ cord-010119-t1x9gknd 12128 13 communication communication NN cord-010119-t1x9gknd 12128 14 of of IN cord-010119-t1x9gknd 12128 15 antibody antibody NN cord-010119-t1x9gknd 12128 16 identification identification NN cord-010119-t1x9gknd 12128 17 . . . cord-010119-t1x9gknd 12129 1 Blood Blood NNP cord-010119-t1x9gknd 12129 2 Bank Bank NNP cord-010119-t1x9gknd 12129 3 Verbal Verbal NNP cord-010119-t1x9gknd 12129 4 Tool tool NN cord-010119-t1x9gknd 12129 5 Implementation implementation NN cord-010119-t1x9gknd 12129 6 for for IN cord-010119-t1x9gknd 12129 7 Cardiovascular cardiovascular JJ cord-010119-t1x9gknd 12129 8 Surgery surgery NN cord-010119-t1x9gknd 12130 1 Rita Rita NNP cord-010119-t1x9gknd 12130 2 Louie Louie NNP cord-010119-t1x9gknd 12130 3 * * NFP cord-010119-t1x9gknd 12130 4 1 1 CD cord-010119-t1x9gknd 12130 5 , , , cord-010119-t1x9gknd 12130 6 Shailesh Shailesh NNP cord-010119-t1x9gknd 12130 7 Macwan Macwan NNP cord-010119-t1x9gknd 12130 8 1 1 CD cord-010119-t1x9gknd 12130 9 , , , cord-010119-t1x9gknd 12130 10 Nancy Nancy NNP cord-010119-t1x9gknd 12130 11 Nikolis Nikolis NNP cord-010119-t1x9gknd 12130 12 1 1 CD cord-010119-t1x9gknd 12130 13 , , , cord-010119-t1x9gknd 12130 14 Arline Arline NNP cord-010119-t1x9gknd 12130 15 Stein Stein NNP cord-010119-t1x9gknd 12130 16 1 1 CD cord-010119-t1x9gknd 12130 17 , , , cord-010119-t1x9gknd 12130 18 Janelle Janelle NNP cord-010119-t1x9gknd 12130 19 Richardson Richardson NNP cord-010119-t1x9gknd 12130 20 1 1 CD cord-010119-t1x9gknd 12130 21 , , , cord-010119-t1x9gknd 12130 22 Manju Manju NNP cord-010119-t1x9gknd 12130 23 Bagu Bagu NNP cord-010119-t1x9gknd 12130 24 1 1 CD cord-010119-t1x9gknd 12130 25 , , , cord-010119-t1x9gknd 12130 26 Lennart Lennart NNP cord-010119-t1x9gknd 12130 27 Logdberg Logdberg NNP cord-010119-t1x9gknd 12130 28 1 1 CD cord-010119-t1x9gknd 12130 29 , , , cord-010119-t1x9gknd 12130 30 Alexander Alexander NNP cord-010119-t1x9gknd 12130 31 Indrikovs Indrikovs NNP cord-010119-t1x9gknd 12130 32 2 2 CD cord-010119-t1x9gknd 12130 33 , , , cord-010119-t1x9gknd 12130 34 Vishesh Vishesh NNP cord-010119-t1x9gknd 12130 35 Chhibber Chhibber NNP cord-010119-t1x9gknd 12130 36 1 1 CD cord-010119-t1x9gknd 12130 37 and and CC cord-010119-t1x9gknd 12130 38 Sherry Sherry NNP cord-010119-t1x9gknd 12130 39 Shariatmadar Shariatmadar NNP cord-010119-t1x9gknd 12130 40 1 1 CD cord-010119-t1x9gknd 12130 41 . . . cord-010119-t1x9gknd 12131 1 1 1 CD cord-010119-t1x9gknd 12131 2 North North NNP cord-010119-t1x9gknd 12131 3 Shore Shore NNP cord-010119-t1x9gknd 12131 4 University University NNP cord-010119-t1x9gknd 12131 5 Hospital Hospital NNP cord-010119-t1x9gknd 12131 6 , , , cord-010119-t1x9gknd 12131 7 2 2 CD cord-010119-t1x9gknd 12131 8 Northwell Northwell NNP cord-010119-t1x9gknd 12131 9 Health Health NNP cord-010119-t1x9gknd 12131 10 Background Background NNP cord-010119-t1x9gknd 12131 11 / / SYM cord-010119-t1x9gknd 12131 12 Case Case NNP cord-010119-t1x9gknd 12131 13 Studies Studies NNPS cord-010119-t1x9gknd 12132 1 : : : cord-010119-t1x9gknd 12132 2 Our -PRON- PRP$ cord-010119-t1x9gknd 12132 3 institution institution NN cord-010119-t1x9gknd 12132 4 is be VBZ cord-010119-t1x9gknd 12132 5 a a DT cord-010119-t1x9gknd 12132 6 tertiary tertiary JJ cord-010119-t1x9gknd 12132 7 care care NN cord-010119-t1x9gknd 12132 8 facility facility NN cord-010119-t1x9gknd 12132 9 performing perform VBG cord-010119-t1x9gknd 12132 10 over over IN cord-010119-t1x9gknd 12132 11 1500 1500 CD cord-010119-t1x9gknd 12132 12 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 12132 13 surgeries surgery NNS cord-010119-t1x9gknd 12132 14 ( ( -LRB- cord-010119-t1x9gknd 12132 15 CVS CVS NNP cord-010119-t1x9gknd 12132 16 ) ) -RRB- cord-010119-t1x9gknd 12132 17 in in IN cord-010119-t1x9gknd 12132 18 2016 2016 CD cord-010119-t1x9gknd 12132 19 , , , cord-010119-t1x9gknd 12132 20 an an DT cord-010119-t1x9gknd 12132 21 increase increase NN cord-010119-t1x9gknd 12132 22 of of IN cord-010119-t1x9gknd 12132 23 117 117 CD cord-010119-t1x9gknd 12132 24 % % NN cord-010119-t1x9gknd 12132 25 after after IN cord-010119-t1x9gknd 12132 26 the the DT cord-010119-t1x9gknd 12132 27 healthcare healthcare NN cord-010119-t1x9gknd 12132 28 system system NN cord-010119-t1x9gknd 12132 29 CVS CVS NNP cord-010119-t1x9gknd 12132 30 integration integration NN cord-010119-t1x9gknd 12132 31 in in IN cord-010119-t1x9gknd 12132 32 2015 2015 CD cord-010119-t1x9gknd 12132 33 . . . cord-010119-t1x9gknd 12133 1 Transfusion transfusion NN cord-010119-t1x9gknd 12133 2 support support NN cord-010119-t1x9gknd 12133 3 of of IN cord-010119-t1x9gknd 12133 4 these these DT cord-010119-t1x9gknd 12133 5 patients patient NNS cord-010119-t1x9gknd 12133 6 includes include VBZ cord-010119-t1x9gknd 12133 7 preoperative preoperative JJ cord-010119-t1x9gknd 12133 8 preparation preparation NN cord-010119-t1x9gknd 12133 9 of of IN cord-010119-t1x9gknd 12133 10 PRBCs prbc NNS cord-010119-t1x9gknd 12133 11 according accord VBG cord-010119-t1x9gknd 12133 12 to to IN cord-010119-t1x9gknd 12133 13 a a DT cord-010119-t1x9gknd 12133 14 maximum maximum JJ cord-010119-t1x9gknd 12133 15 surgical surgical JJ cord-010119-t1x9gknd 12133 16 blood blood NN cord-010119-t1x9gknd 12133 17 order order NN cord-010119-t1x9gknd 12133 18 schedule schedule NN cord-010119-t1x9gknd 12133 19 . . . cord-010119-t1x9gknd 12134 1 Additional additional JJ cord-010119-t1x9gknd 12134 2 blood blood NN cord-010119-t1x9gknd 12134 3 components component NNS cord-010119-t1x9gknd 12134 4 are be VBP cord-010119-t1x9gknd 12134 5 issued issue VBN cord-010119-t1x9gknd 12134 6 as as IN cord-010119-t1x9gknd 12134 7 orders order NNS cord-010119-t1x9gknd 12134 8 are be VBP cord-010119-t1x9gknd 12134 9 placed place VBN cord-010119-t1x9gknd 12134 10 . . . cord-010119-t1x9gknd 12135 1 Until until IN cord-010119-t1x9gknd 12135 2 December December NNP cord-010119-t1x9gknd 12135 3 2016 2016 CD cord-010119-t1x9gknd 12135 4 , , , cord-010119-t1x9gknd 12135 5 the the DT cord-010119-t1x9gknd 12135 6 additional additional JJ cord-010119-t1x9gknd 12135 7 written write VBN cord-010119-t1x9gknd 12135 8 orders order NNS cord-010119-t1x9gknd 12135 9 were be VBD cord-010119-t1x9gknd 12135 10 submitted submit VBN cord-010119-t1x9gknd 12135 11 to to IN cord-010119-t1x9gknd 12135 12 the the DT cord-010119-t1x9gknd 12135 13 blood blood NN cord-010119-t1x9gknd 12135 14 bank bank NN cord-010119-t1x9gknd 12135 15 via via IN cord-010119-t1x9gknd 12135 16 the the DT cord-010119-t1x9gknd 12135 17 pneumatic pneumatic JJ cord-010119-t1x9gknd 12135 18 tube tube NN cord-010119-t1x9gknd 12135 19 system system NN cord-010119-t1x9gknd 12135 20 without without IN cord-010119-t1x9gknd 12135 21 further further JJ cord-010119-t1x9gknd 12135 22 communication communication NN cord-010119-t1x9gknd 12135 23 . . . cord-010119-t1x9gknd 12136 1 After after IN cord-010119-t1x9gknd 12136 2 2 2 CD cord-010119-t1x9gknd 12136 3 reported report VBD cord-010119-t1x9gknd 12136 4 events event NNS cord-010119-t1x9gknd 12136 5 in in IN cord-010119-t1x9gknd 12136 6 Q3 Q3 NNP cord-010119-t1x9gknd 12136 7 2016 2016 CD cord-010119-t1x9gknd 12136 8 that that WDT cord-010119-t1x9gknd 12136 9 resulted result VBD cord-010119-t1x9gknd 12136 10 in in IN cord-010119-t1x9gknd 12136 11 delays delay NNS cord-010119-t1x9gknd 12136 12 in in IN cord-010119-t1x9gknd 12136 13 blood blood NN cord-010119-t1x9gknd 12136 14 transfusion transfusion NN cord-010119-t1x9gknd 12136 15 , , , cord-010119-t1x9gknd 12136 16 we -PRON- PRP cord-010119-t1x9gknd 12136 17 examined examine VBD cord-010119-t1x9gknd 12136 18 our -PRON- PRP$ cord-010119-t1x9gknd 12136 19 process process NN cord-010119-t1x9gknd 12136 20 very very RB cord-010119-t1x9gknd 12136 21 closely closely RB cord-010119-t1x9gknd 12136 22 and and CC cord-010119-t1x9gknd 12136 23 identified identify VBN cord-010119-t1x9gknd 12136 24 opportunities opportunity NNS cord-010119-t1x9gknd 12136 25 for for IN cord-010119-t1x9gknd 12136 26 improvements improvement NNS cord-010119-t1x9gknd 12136 27 . . . cord-010119-t1x9gknd 12137 1 In in IN cord-010119-t1x9gknd 12137 2 collaboration collaboration NN cord-010119-t1x9gknd 12137 3 with with IN cord-010119-t1x9gknd 12137 4 CVS CVS NNP cord-010119-t1x9gknd 12137 5 , , , cord-010119-t1x9gknd 12137 6 the the DT cord-010119-t1x9gknd 12137 7 Blood Blood NNP cord-010119-t1x9gknd 12137 8 Bank Bank NNP cord-010119-t1x9gknd 12137 9 implemented implement VBD cord-010119-t1x9gknd 12137 10 a a DT cord-010119-t1x9gknd 12137 11 new new JJ cord-010119-t1x9gknd 12137 12 workflow workflow NN cord-010119-t1x9gknd 12137 13 process process NN cord-010119-t1x9gknd 12137 14 to to TO cord-010119-t1x9gknd 12137 15 enhance enhance VB cord-010119-t1x9gknd 12137 16 communication communication NN cord-010119-t1x9gknd 12137 17 with with IN cord-010119-t1x9gknd 12137 18 the the DT cord-010119-t1x9gknd 12137 19 CVS CVS NNP cord-010119-t1x9gknd 12137 20 team team NN cord-010119-t1x9gknd 12137 21 , , , cord-010119-t1x9gknd 12137 22 reduce reduce VB cord-010119-t1x9gknd 12137 23 turnaround turnaround NN cord-010119-t1x9gknd 12137 24 time time NN cord-010119-t1x9gknd 12137 25 and and CC cord-010119-t1x9gknd 12137 26 improve improve VB cord-010119-t1x9gknd 12137 27 patient patient JJ cord-010119-t1x9gknd 12137 28 safety safety NN cord-010119-t1x9gknd 12137 29 . . . cord-010119-t1x9gknd 12138 1 Study Study NNP cord-010119-t1x9gknd 12138 2 Design Design NNP cord-010119-t1x9gknd 12138 3 / / SYM cord-010119-t1x9gknd 12138 4 Method method NN cord-010119-t1x9gknd 12138 5 : : : cord-010119-t1x9gknd 12138 6 1 1 CD cord-010119-t1x9gknd 12138 7 . . . cord-010119-t1x9gknd 12139 1 Open open JJ cord-010119-t1x9gknd 12139 2 discussions discussion NNS cord-010119-t1x9gknd 12139 3 and and CC cord-010119-t1x9gknd 12139 4 collaboration collaboration NN cord-010119-t1x9gknd 12139 5 between between IN cord-010119-t1x9gknd 12139 6 blood blood NN cord-010119-t1x9gknd 12139 7 bank bank NN cord-010119-t1x9gknd 12139 8 and and CC cord-010119-t1x9gknd 12139 9 CVS CVS NNP cord-010119-t1x9gknd 12139 10 nursing nursing NN cord-010119-t1x9gknd 12139 11 teams team NNS cord-010119-t1x9gknd 12139 12 2 2 CD cord-010119-t1x9gknd 12139 13 . . . cord-010119-t1x9gknd 12140 1 Mapping map VBG cord-010119-t1x9gknd 12140 2 the the DT cord-010119-t1x9gknd 12140 3 process process NN cord-010119-t1x9gknd 12140 4 using use VBG cord-010119-t1x9gknd 12140 5 flowcharts flowchart NNS cord-010119-t1x9gknd 12140 6 for for IN cord-010119-t1x9gknd 12140 7 additional additional JJ cord-010119-t1x9gknd 12140 8 blood blood NN cord-010119-t1x9gknd 12140 9 orders order NNS cord-010119-t1x9gknd 12140 10 from from IN cord-010119-t1x9gknd 12140 11 CVS CVS NNP cord-010119-t1x9gknd 12140 12 . . . cord-010119-t1x9gknd 12141 1 3 3 LS cord-010119-t1x9gknd 12141 2 . . . cord-010119-t1x9gknd 12142 1 Identify identify VB cord-010119-t1x9gknd 12142 2 bottlenecks bottleneck NNS cord-010119-t1x9gknd 12142 3 and and CC cord-010119-t1x9gknd 12142 4 brainstorm brainstorm VB cord-010119-t1x9gknd 12142 5 solutions solution NNS cord-010119-t1x9gknd 12142 6 . . . cord-010119-t1x9gknd 12143 1 4 4 LS cord-010119-t1x9gknd 12143 2 . . . cord-010119-t1x9gknd 12144 1 A a DT cord-010119-t1x9gknd 12144 2 verbal verbal JJ cord-010119-t1x9gknd 12144 3 CVS CVS NNP cord-010119-t1x9gknd 12144 4 order order NN cord-010119-t1x9gknd 12144 5 process process NN cord-010119-t1x9gknd 12144 6 and and CC cord-010119-t1x9gknd 12144 7 form form NN cord-010119-t1x9gknd 12144 8 was be VBD cord-010119-t1x9gknd 12144 9 implemented implement VBN cord-010119-t1x9gknd 12144 10 to to TO cord-010119-t1x9gknd 12144 11 improve improve VB cord-010119-t1x9gknd 12144 12 communication communication NN cord-010119-t1x9gknd 12144 13 between between IN cord-010119-t1x9gknd 12144 14 CVS CVS NNP cord-010119-t1x9gknd 12144 15 and and CC cord-010119-t1x9gknd 12144 16 Blood Blood NNP cord-010119-t1x9gknd 12144 17 Bank Bank NNP cord-010119-t1x9gknd 12144 18 , , , cord-010119-t1x9gknd 12144 19 which which WDT cord-010119-t1x9gknd 12144 20 solidified solidify VBD cord-010119-t1x9gknd 12144 21 communication communication NN cord-010119-t1x9gknd 12144 22 by by IN cord-010119-t1x9gknd 12144 23 including include VBG cord-010119-t1x9gknd 12144 24 the the DT cord-010119-t1x9gknd 12144 25 time time NN cord-010119-t1x9gknd 12144 26 of of IN cord-010119-t1x9gknd 12144 27 the the DT cord-010119-t1x9gknd 12144 28 order order NN cord-010119-t1x9gknd 12144 29 , , , cord-010119-t1x9gknd 12144 30 patient patient JJ cord-010119-t1x9gknd 12144 31 identifiers identifier NNS cord-010119-t1x9gknd 12144 32 , , , cord-010119-t1x9gknd 12144 33 caller caller NN cord-010119-t1x9gknd 12144 34 identification identification NN cord-010119-t1x9gknd 12144 35 , , , cord-010119-t1x9gknd 12144 36 ordering order VBG cord-010119-t1x9gknd 12144 37 prescriber prescriber NN cord-010119-t1x9gknd 12144 38 , , , cord-010119-t1x9gknd 12144 39 staff staff NN cord-010119-t1x9gknd 12144 40 receiving receive VBG cord-010119-t1x9gknd 12144 41 order order NN cord-010119-t1x9gknd 12144 42 , , , cord-010119-t1x9gknd 12144 43 the the DT cord-010119-t1x9gknd 12144 44 quantity quantity NN cord-010119-t1x9gknd 12144 45 and and CC cord-010119-t1x9gknd 12144 46 kinds kind NNS cord-010119-t1x9gknd 12144 47 of of IN cord-010119-t1x9gknd 12144 48 products product NNS cord-010119-t1x9gknd 12144 49 ordered order VBN cord-010119-t1x9gknd 12144 50 , , , cord-010119-t1x9gknd 12144 51 the the DT cord-010119-t1x9gknd 12144 52 mode mode NN cord-010119-t1x9gknd 12144 53 of of IN cord-010119-t1x9gknd 12144 54 order order NN cord-010119-t1x9gknd 12144 55 delivery delivery NN cord-010119-t1x9gknd 12144 56 , , , cord-010119-t1x9gknd 12144 57 and and CC cord-010119-t1x9gknd 12144 58 anticipated anticipate VBN cord-010119-t1x9gknd 12144 59 future future JJ cord-010119-t1x9gknd 12144 60 orders order NNS cord-010119-t1x9gknd 12144 61 . . . cord-010119-t1x9gknd 12145 1 A a DT cord-010119-t1x9gknd 12145 2 Read read NN cord-010119-t1x9gknd 12145 3 Back back RB cord-010119-t1x9gknd 12145 4 was be VBD cord-010119-t1x9gknd 12145 5 also also RB cord-010119-t1x9gknd 12145 6 documented document VBN cord-010119-t1x9gknd 12145 7 for for IN cord-010119-t1x9gknd 12145 8 verification verification NN cord-010119-t1x9gknd 12145 9 of of IN cord-010119-t1x9gknd 12145 10 the the DT cord-010119-t1x9gknd 12145 11 order order NN cord-010119-t1x9gknd 12145 12 . . . cord-010119-t1x9gknd 12146 1 5 5 LS cord-010119-t1x9gknd 12146 2 . . . cord-010119-t1x9gknd 12147 1 The the DT cord-010119-t1x9gknd 12147 2 blood blood NN cord-010119-t1x9gknd 12147 3 bank bank NN cord-010119-t1x9gknd 12147 4 staff staff NN cord-010119-t1x9gknd 12147 5 immediately immediately RB cord-010119-t1x9gknd 12147 6 processes process VBZ cord-010119-t1x9gknd 12147 7 this this DT cord-010119-t1x9gknd 12147 8 order order NN cord-010119-t1x9gknd 12147 9 while while IN cord-010119-t1x9gknd 12147 10 waiting wait VBG cord-010119-t1x9gknd 12147 11 for for IN cord-010119-t1x9gknd 12147 12 the the DT cord-010119-t1x9gknd 12147 13 written write VBN cord-010119-t1x9gknd 12147 14 order order NN cord-010119-t1x9gknd 12147 15 to to TO cord-010119-t1x9gknd 12147 16 arrive arrive VB cord-010119-t1x9gknd 12147 17 . . . cord-010119-t1x9gknd 12148 1 Upon upon IN cord-010119-t1x9gknd 12148 2 receipt receipt NN cord-010119-t1x9gknd 12148 3 of of IN cord-010119-t1x9gknd 12148 4 the the DT cord-010119-t1x9gknd 12148 5 written write VBN cord-010119-t1x9gknd 12148 6 order order NN cord-010119-t1x9gknd 12148 7 the the DT cord-010119-t1x9gknd 12148 8 blood blood NN cord-010119-t1x9gknd 12148 9 is be VBZ cord-010119-t1x9gknd 12148 10 issued issue VBN cord-010119-t1x9gknd 12148 11 to to IN cord-010119-t1x9gknd 12148 12 the the DT cord-010119-t1x9gknd 12148 13 OR OR NNP cord-010119-t1x9gknd 12148 14 . . . cord-010119-t1x9gknd 12149 1 6 6 LS cord-010119-t1x9gknd 12149 2 . . . cord-010119-t1x9gknd 12150 1 Follow Follow NNP cord-010119-t1x9gknd 12150 2 Plan Plan NNP cord-010119-t1x9gknd 12150 3 - - HYPH cord-010119-t1x9gknd 12150 4 Do do VB cord-010119-t1x9gknd 12150 5 - - HYPH cord-010119-t1x9gknd 12150 6 Check check VB cord-010119-t1x9gknd 12150 7 - - HYPH cord-010119-t1x9gknd 12150 8 Act Act NNP cord-010119-t1x9gknd 12150 9 . . . cord-010119-t1x9gknd 12151 1 The the DT cord-010119-t1x9gknd 12151 2 Transfusion Transfusion NNP cord-010119-t1x9gknd 12151 3 Safety Safety NNP cord-010119-t1x9gknd 12151 4 Officer Officer NNP cord-010119-t1x9gknd 12151 5 reviews review VBZ cord-010119-t1x9gknd 12151 6 each each DT cord-010119-t1x9gknd 12151 7 order order NN cord-010119-t1x9gknd 12151 8 for for IN cord-010119-t1x9gknd 12151 9 the the DT cord-010119-t1x9gknd 12151 10 following follow VBG cord-010119-t1x9gknd 12151 11 parameters parameter NNS cord-010119-t1x9gknd 12151 12 : : : cord-010119-t1x9gknd 12151 13 number number NN cord-010119-t1x9gknd 12151 14 / / SYM cord-010119-t1x9gknd 12151 15 type type NN cord-010119-t1x9gknd 12151 16 of of IN cord-010119-t1x9gknd 12151 17 products product NNS cord-010119-t1x9gknd 12151 18 , , , cord-010119-t1x9gknd 12151 19 turn turn VB cord-010119-t1x9gknd 12151 20 around around RP cord-010119-t1x9gknd 12151 21 times time NNS cord-010119-t1x9gknd 12151 22 ( ( -LRB- cord-010119-t1x9gknd 12151 23 TAT tat NN cord-010119-t1x9gknd 12151 24 ) ) -RRB- cord-010119-t1x9gknd 12151 25 , , , cord-010119-t1x9gknd 12151 26 wastage wastage NN cord-010119-t1x9gknd 12151 27 / / SYM cord-010119-t1x9gknd 12151 28 returned return VBD cord-010119-t1x9gknd 12151 29 products product NNS cord-010119-t1x9gknd 12151 30 and and CC cord-010119-t1x9gknd 12151 31 overall overall JJ cord-010119-t1x9gknd 12151 32 efficacy efficacy NN cord-010119-t1x9gknd 12151 33 since since IN cord-010119-t1x9gknd 12151 34 implementation implementation NN cord-010119-t1x9gknd 12151 35 of of IN cord-010119-t1x9gknd 12151 36 this this DT cord-010119-t1x9gknd 12151 37 process process NN cord-010119-t1x9gknd 12151 38 . . . cord-010119-t1x9gknd 12152 1 Results/ Results/ . cord-010119-t1x9gknd 12153 1 Finding find VBG cord-010119-t1x9gknd 12154 1 : : : cord-010119-t1x9gknd 12154 2 A a DT cord-010119-t1x9gknd 12154 3 significant significant JJ cord-010119-t1x9gknd 12154 4 improvement improvement NN cord-010119-t1x9gknd 12154 5 was be VBD cord-010119-t1x9gknd 12154 6 noted note VBN cord-010119-t1x9gknd 12154 7 in in IN cord-010119-t1x9gknd 12154 8 communication communication NN cord-010119-t1x9gknd 12154 9 and and CC cord-010119-t1x9gknd 12154 10 TAT tat NN cord-010119-t1x9gknd 12154 11 after after IN cord-010119-t1x9gknd 12154 12 implementation implementation NN cord-010119-t1x9gknd 12154 13 of of IN cord-010119-t1x9gknd 12154 14 the the DT cord-010119-t1x9gknd 12154 15 process process NN cord-010119-t1x9gknd 12154 16 described describe VBN cord-010119-t1x9gknd 12154 17 above above RB cord-010119-t1x9gknd 12154 18 . . . cord-010119-t1x9gknd 12155 1 For for IN cord-010119-t1x9gknd 12155 2 the the DT cord-010119-t1x9gknd 12155 3 period period NN cord-010119-t1x9gknd 12155 4 12/23/16 12/23/16 CD cord-010119-t1x9gknd 12155 5 - - SYM cord-010119-t1x9gknd 12155 6 4/7/17 4/7/17 CD cord-010119-t1x9gknd 12155 7 the the DT cord-010119-t1x9gknd 12155 8 blood blood NN cord-010119-t1x9gknd 12155 9 bank bank NN cord-010119-t1x9gknd 12155 10 has have VBZ cord-010119-t1x9gknd 12155 11 received receive VBN cord-010119-t1x9gknd 12155 12 327 327 CD cord-010119-t1x9gknd 12155 13 verbal verbal JJ cord-010119-t1x9gknd 12155 14 orders order NNS cord-010119-t1x9gknd 12155 15 with with IN cord-010119-t1x9gknd 12155 16 varying vary VBG cord-010119-t1x9gknd 12155 17 product product NN cord-010119-t1x9gknd 12155 18 combinations combination NNS cord-010119-t1x9gknd 12155 19 . . . cord-010119-t1x9gknd 12156 1 The the DT cord-010119-t1x9gknd 12156 2 table table NN cord-010119-t1x9gknd 12156 3 below below RB cord-010119-t1x9gknd 12156 4 represents represent VBZ cord-010119-t1x9gknd 12156 5 average average JJ cord-010119-t1x9gknd 12156 6 turn turn NN cord-010119-t1x9gknd 12156 7 - - HYPH cord-010119-t1x9gknd 12156 8 around around RP cord-010119-t1x9gknd 12156 9 times time NNS cord-010119-t1x9gknd 12156 10 to to TO cord-010119-t1x9gknd 12156 11 issue issue VB cord-010119-t1x9gknd 12156 12 blood blood NN cord-010119-t1x9gknd 12156 13 products product NNS cord-010119-t1x9gknd 12156 14 : : : cord-010119-t1x9gknd 12156 15 Conclusion conclusion NN cord-010119-t1x9gknd 12156 16 : : : cord-010119-t1x9gknd 12157 1 The the DT cord-010119-t1x9gknd 12157 2 introduction introduction NN cord-010119-t1x9gknd 12157 3 of of IN cord-010119-t1x9gknd 12157 4 the the DT cord-010119-t1x9gknd 12157 5 verbal verbal JJ cord-010119-t1x9gknd 12157 6 order order NN cord-010119-t1x9gknd 12157 7 tool tool NN cord-010119-t1x9gknd 12157 8 for for IN cord-010119-t1x9gknd 12157 9 CVS CVS NNP cord-010119-t1x9gknd 12157 10 has have VBZ cord-010119-t1x9gknd 12157 11 streamlined streamline VBN cord-010119-t1x9gknd 12157 12 the the DT cord-010119-t1x9gknd 12157 13 blood blood NN cord-010119-t1x9gknd 12157 14 ordering ordering NN cord-010119-t1x9gknd 12157 15 process process NN cord-010119-t1x9gknd 12157 16 leading lead VBG cord-010119-t1x9gknd 12157 17 to to IN cord-010119-t1x9gknd 12157 18 increased increase VBN cord-010119-t1x9gknd 12157 19 efficiency efficiency NN cord-010119-t1x9gknd 12157 20 and and CC cord-010119-t1x9gknd 12157 21 lower low JJR cord-010119-t1x9gknd 12157 22 TAT tat NN cord-010119-t1x9gknd 12157 23 . . . cord-010119-t1x9gknd 12158 1 Effective effective JJ cord-010119-t1x9gknd 12158 2 communication communication NN cord-010119-t1x9gknd 12158 3 between between IN cord-010119-t1x9gknd 12158 4 the the DT cord-010119-t1x9gknd 12158 5 OR or JJ cord-010119-t1x9gknd 12158 6 team team NN cord-010119-t1x9gknd 12158 7 and and CC cord-010119-t1x9gknd 12158 8 transfusion transfusion NN cord-010119-t1x9gknd 12158 9 service service NN cord-010119-t1x9gknd 12158 10 is be VBZ cord-010119-t1x9gknd 12158 11 the the DT cord-010119-t1x9gknd 12158 12 key key NN cord-010119-t1x9gknd 12158 13 to to IN cord-010119-t1x9gknd 12158 14 timely timely JJ cord-010119-t1x9gknd 12158 15 provision provision NN cord-010119-t1x9gknd 12158 16 of of IN cord-010119-t1x9gknd 12158 17 blood blood NN cord-010119-t1x9gknd 12158 18 products product NNS cord-010119-t1x9gknd 12158 19 for for IN cord-010119-t1x9gknd 12158 20 these these DT cord-010119-t1x9gknd 12158 21 critical critical JJ cord-010119-t1x9gknd 12158 22 patients patient NNS cord-010119-t1x9gknd 12158 23 . . . cord-010119-t1x9gknd 12159 1 Challenge challenge NN cord-010119-t1x9gknd 12159 2 of of IN cord-010119-t1x9gknd 12159 3 Blood blood NN cord-010119-t1x9gknd 12159 4 Type type NN cord-010119-t1x9gknd 12159 5 Testing testing NN cord-010119-t1x9gknd 12159 6 for for IN cord-010119-t1x9gknd 12159 7 Multiply Multiply NNP cord-010119-t1x9gknd 12159 8 Transfused Transfused NNP cord-010119-t1x9gknd 12159 9 Sickle Sickle NNP cord-010119-t1x9gknd 12159 10 Cell Cell NNP cord-010119-t1x9gknd 12159 11 Disease Disease NNP cord-010119-t1x9gknd 12159 12 Patients Patients NNP cord-010119-t1x9gknd 12159 13 Jayanna Jayanna NNP cord-010119-t1x9gknd 12159 14 Slayten Slayten NNP cord-010119-t1x9gknd 12160 1 * * NFP cord-010119-t1x9gknd 12160 2 1 1 CD cord-010119-t1x9gknd 12160 3 , , , cord-010119-t1x9gknd 12160 4 Tracie Tracie NNP cord-010119-t1x9gknd 12160 5 Ingle Ingle NNP cord-010119-t1x9gknd 12160 6 1 1 CD cord-010119-t1x9gknd 12160 7 and and CC cord-010119-t1x9gknd 12160 8 Heather Heather NNP cord-010119-t1x9gknd 12160 9 Vaught Vaught NNP cord-010119-t1x9gknd 12160 10 2 2 CD cord-010119-t1x9gknd 12160 11 . . . cord-010119-t1x9gknd 12161 1 1 1 LS cord-010119-t1x9gknd 12162 1 Indiana Indiana NNP cord-010119-t1x9gknd 12162 2 University University NNP cord-010119-t1x9gknd 12162 3 Health Health NNP cord-010119-t1x9gknd 12162 4 , , , cord-010119-t1x9gknd 12162 5 2 2 CD cord-010119-t1x9gknd 12162 6 Indiana Indiana NNP cord-010119-t1x9gknd 12162 7 University University NNP cord-010119-t1x9gknd 12162 8 Health Health NNP cord-010119-t1x9gknd 12162 9 ( ( -LRB- cord-010119-t1x9gknd 12162 10 IU IU NNP cord-010119-t1x9gknd 12162 11 Health Health NNP cord-010119-t1x9gknd 12162 12 ) ) -RRB- cord-010119-t1x9gknd 12163 1 Background Background NNP cord-010119-t1x9gknd 12163 2 / / SYM cord-010119-t1x9gknd 12163 3 Case Case NNP cord-010119-t1x9gknd 12163 4 Studies Studies NNPS cord-010119-t1x9gknd 12164 1 : : : cord-010119-t1x9gknd 12164 2 We -PRON- PRP cord-010119-t1x9gknd 12164 3 report report VBP cord-010119-t1x9gknd 12164 4 our -PRON- PRP$ cord-010119-t1x9gknd 12164 5 Midwestern Midwestern NNP cord-010119-t1x9gknd 12164 6 , , , cord-010119-t1x9gknd 12164 7 University University NNP cord-010119-t1x9gknd 12164 8 Transfusion Transfusion NNP cord-010119-t1x9gknd 12164 9 Service Service NNP cord-010119-t1x9gknd 12164 10 challenge challenge NN cord-010119-t1x9gknd 12164 11 of of IN cord-010119-t1x9gknd 12164 12 obtaining obtain VBG cord-010119-t1x9gknd 12164 13 the the DT cord-010119-t1x9gknd 12164 14 correct correct JJ cord-010119-t1x9gknd 12164 15 blood blood NN cord-010119-t1x9gknd 12164 16 types type NNS cord-010119-t1x9gknd 12164 17 in in IN cord-010119-t1x9gknd 12164 18 RBC RBC NNP cord-010119-t1x9gknd 12164 19 exchanged exchange VBD cord-010119-t1x9gknd 12164 20 Sickle Sickle NNP cord-010119-t1x9gknd 12164 21 Cell Cell NNP cord-010119-t1x9gknd 12164 22 Disease Disease NNP cord-010119-t1x9gknd 12164 23 ( ( -LRB- cord-010119-t1x9gknd 12164 24 SCD SCD NNP cord-010119-t1x9gknd 12164 25 ) ) -RRB- cord-010119-t1x9gknd 12164 26 patients patient NNS cord-010119-t1x9gknd 12164 27 tested test VBN cord-010119-t1x9gknd 12164 28 by by IN cord-010119-t1x9gknd 12164 29 our -PRON- PRP$ cord-010119-t1x9gknd 12164 30 primary primary JJ cord-010119-t1x9gknd 12164 31 testing testing NN cord-010119-t1x9gknd 12164 32 method method NN cord-010119-t1x9gknd 12164 33 , , , cord-010119-t1x9gknd 12164 34 solid solid JJ cord-010119-t1x9gknd 12164 35 - - HYPH cord-010119-t1x9gknd 12164 36 phase phase NN cord-010119-t1x9gknd 12164 37 red red JJ cord-010119-t1x9gknd 12164 38 cell cell NN cord-010119-t1x9gknd 12164 39 adherence adherence NN cord-010119-t1x9gknd 12164 40 analyzer analyzer NN cord-010119-t1x9gknd 12164 41 ECHO echo NN cord-010119-t1x9gknd 12164 42 ( ( -LRB- cord-010119-t1x9gknd 12164 43 Immucor Immucor NNP cord-010119-t1x9gknd 12164 44 . . . cord-010119-t1x9gknd 12164 45 Norcross Norcross NNP cord-010119-t1x9gknd 12164 46 , , , cord-010119-t1x9gknd 12164 47 GA GA NNP cord-010119-t1x9gknd 12164 48 ) ) -RRB- cord-010119-t1x9gknd 12164 49 . . . cord-010119-t1x9gknd 12165 1 The the DT cord-010119-t1x9gknd 12165 2 ECHO ECHO NNP cord-010119-t1x9gknd 12165 3 Operation Operation NNP cord-010119-t1x9gknd 12165 4 Manual Manual NNP cord-010119-t1x9gknd 12165 5 in in IN cord-010119-t1x9gknd 12165 6 Chapter Chapter NNP cord-010119-t1x9gknd 12165 7 12 12 CD cord-010119-t1x9gknd 12165 8 - - SYM cord-010119-t1x9gknd 12165 9 6 6 CD cord-010119-t1x9gknd 12165 10 and and CC cord-010119-t1x9gknd 12165 11 Appendix Appendix NNP cord-010119-t1x9gknd 12165 12 D D NNP cord-010119-t1x9gknd 12166 1 it -PRON- PRP cord-010119-t1x9gknd 12166 2 states state VBZ cord-010119-t1x9gknd 12166 3 : : : cord-010119-t1x9gknd 12166 4 " " `` cord-010119-t1x9gknd 12166 5 Warning warning NN cord-010119-t1x9gknd 12166 6 : : : cord-010119-t1x9gknd 12167 1 The the DT cord-010119-t1x9gknd 12167 2 Galileo Galileo NNP cord-010119-t1x9gknd 12167 3 ECHO echo NN cord-010119-t1x9gknd 12167 4 can can MD cord-010119-t1x9gknd 12167 5 not not RB cord-010119-t1x9gknd 12167 6 reliably reliably RB cord-010119-t1x9gknd 12167 7 detect detect VB cord-010119-t1x9gknd 12167 8 hemagglutination hemagglutination NN cord-010119-t1x9gknd 12167 9 reactions reaction NNS cord-010119-t1x9gknd 12167 10 that that WDT cord-010119-t1x9gknd 12167 11 are be VBP cord-010119-t1x9gknd 12167 12 graded grade VBN cord-010119-t1x9gknd 12167 13 as as IN cord-010119-t1x9gknd 12167 14 11 11 CD cord-010119-t1x9gknd 12167 15 or or CC cord-010119-t1x9gknd 12167 16 less less JJR cord-010119-t1x9gknd 12167 17 in in IN cord-010119-t1x9gknd 12167 18 tube tube NN cord-010119-t1x9gknd 12167 19 methodology methodology NN cord-010119-t1x9gknd 12167 20 . . . cord-010119-t1x9gknd 12168 1 The the DT cord-010119-t1x9gknd 12168 2 Galileo Galileo NNP cord-010119-t1x9gknd 12168 3 ECHO echo NN cord-010119-t1x9gknd 12168 4 does do VBZ cord-010119-t1x9gknd 12168 5 not not RB cord-010119-t1x9gknd 12168 6 generate generate VB cord-010119-t1x9gknd 12168 7 as as IN cord-010119-t1x9gknd 12168 8 interpretation interpretation NN cord-010119-t1x9gknd 12168 9 of of IN cord-010119-t1x9gknd 12168 10 mixed mixed JJ cord-010119-t1x9gknd 12168 11 - - HYPH cord-010119-t1x9gknd 12168 12 field field NN cord-010119-t1x9gknd 12168 13 . . . cord-010119-t1x9gknd 12169 1 Such such JJ cord-010119-t1x9gknd 12169 2 a a DT cord-010119-t1x9gknd 12169 3 mixed mixed JJ cord-010119-t1x9gknd 12169 4 - - HYPH cord-010119-t1x9gknd 12169 5 field field NN cord-010119-t1x9gknd 12169 6 reaction reaction NN cord-010119-t1x9gknd 12169 7 will will MD cord-010119-t1x9gknd 12169 8 be be VB cord-010119-t1x9gknd 12169 9 interpreted interpret VBN cord-010119-t1x9gknd 12169 10 as as IN cord-010119-t1x9gknd 12169 11 positive positive JJ cord-010119-t1x9gknd 12169 12 , , , cord-010119-t1x9gknd 12169 13 negative negative JJ cord-010119-t1x9gknd 12169 14 , , , cord-010119-t1x9gknd 12169 15 or or CC cord-010119-t1x9gknd 12169 16 equivocal equivocal JJ cord-010119-t1x9gknd 12169 17 . . . cord-010119-t1x9gknd 12170 1 " " `` cord-010119-t1x9gknd 12170 2 We -PRON- PRP cord-010119-t1x9gknd 12170 3 report report VBP cord-010119-t1x9gknd 12170 4 of of IN cord-010119-t1x9gknd 12170 5 a a DT cord-010119-t1x9gknd 12170 6 challenge challenge NN cord-010119-t1x9gknd 12170 7 with with IN cord-010119-t1x9gknd 12170 8 this this DT cord-010119-t1x9gknd 12170 9 analyzer analyzer NN cord-010119-t1x9gknd 12170 10 limitation limitation NN cord-010119-t1x9gknd 12170 11 which which WDT cord-010119-t1x9gknd 12170 12 impacts impact VBZ cord-010119-t1x9gknd 12170 13 the the DT cord-010119-t1x9gknd 12170 14 assignment assignment NN cord-010119-t1x9gknd 12170 15 of of IN cord-010119-t1x9gknd 12170 16 the the DT cord-010119-t1x9gknd 12170 17 correct correct JJ cord-010119-t1x9gknd 12170 18 blood blood NN cord-010119-t1x9gknd 12170 19 type type NN cord-010119-t1x9gknd 12170 20 for for IN cord-010119-t1x9gknd 12170 21 multiply multiply VB cord-010119-t1x9gknd 12170 22 transfused transfuse VBN cord-010119-t1x9gknd 12170 23 SCD SCD NNP cord-010119-t1x9gknd 12170 24 patients patient NNS cord-010119-t1x9gknd 12170 25 . . . cord-010119-t1x9gknd 12171 1 Study Study NNP cord-010119-t1x9gknd 12171 2 Design Design NNP cord-010119-t1x9gknd 12171 3 / / SYM cord-010119-t1x9gknd 12171 4 Method method NN cord-010119-t1x9gknd 12171 5 : : : cord-010119-t1x9gknd 12172 1 Two two CD cord-010119-t1x9gknd 12172 2 SCD SCD NNP cord-010119-t1x9gknd 12172 3 when when WRB cord-010119-t1x9gknd 12172 4 initially initially RB cord-010119-t1x9gknd 12172 5 tested test VBN cord-010119-t1x9gknd 12172 6 by by IN cord-010119-t1x9gknd 12172 7 the the DT cord-010119-t1x9gknd 12172 8 ECHO ECHO NNP cord-010119-t1x9gknd 12172 9 as as IN cord-010119-t1x9gknd 12172 10 O o UH cord-010119-t1x9gknd 12172 11 , , , cord-010119-t1x9gknd 12172 12 D D NNP cord-010119-t1x9gknd 12172 13 Negative negative NN cord-010119-t1x9gknd 12172 14 ; ; : cord-010119-t1x9gknd 12172 15 however however RB cord-010119-t1x9gknd 12172 16 , , , cord-010119-t1x9gknd 12172 17 each each DT cord-010119-t1x9gknd 12172 18 patient patient NN cord-010119-t1x9gknd 12172 19 was be VBD cord-010119-t1x9gknd 12172 20 historically historically RB cord-010119-t1x9gknd 12172 21 O o UH cord-010119-t1x9gknd 12172 22 , , , cord-010119-t1x9gknd 12172 23 D D NNP cord-010119-t1x9gknd 12172 24 Positive Positive NNP cord-010119-t1x9gknd 12172 25 . . . cord-010119-t1x9gknd 12173 1 Both both DT cord-010119-t1x9gknd 12173 2 patients patient NNS cord-010119-t1x9gknd 12173 3 had have VBD cord-010119-t1x9gknd 12173 4 received receive VBN cord-010119-t1x9gknd 12173 5 a a DT cord-010119-t1x9gknd 12173 6 RBC RBC NNP cord-010119-t1x9gknd 12173 7 exchange exchange NN cord-010119-t1x9gknd 12173 8 transfusion transfusion NN cord-010119-t1x9gknd 12173 9 with with IN cord-010119-t1x9gknd 12173 10 8 8 CD cord-010119-t1x9gknd 12173 11 - - SYM cord-010119-t1x9gknd 12173 12 11 11 CD cord-010119-t1x9gknd 12173 13 O o NN cord-010119-t1x9gknd 12173 14 , , , cord-010119-t1x9gknd 12173 15 D D NNP cord-010119-t1x9gknd 12173 16 Negative negative JJ cord-010119-t1x9gknd 12173 17 red red JJ cord-010119-t1x9gknd 12173 18 blood blood NN cord-010119-t1x9gknd 12173 19 cells cell NNS cord-010119-t1x9gknd 12173 20 over over IN cord-010119-t1x9gknd 12173 21 30 30 CD cord-010119-t1x9gknd 12173 22 days day NNS cord-010119-t1x9gknd 12173 23 previously previously RB cord-010119-t1x9gknd 12173 24 . . . cord-010119-t1x9gknd 12174 1 Repeat repeat NN cord-010119-t1x9gknd 12174 2 testing testing NN cord-010119-t1x9gknd 12174 3 of of IN cord-010119-t1x9gknd 12174 4 the the DT cord-010119-t1x9gknd 12174 5 samples sample NNS cord-010119-t1x9gknd 12174 6 was be VBD cord-010119-t1x9gknd 12174 7 completed complete VBN cord-010119-t1x9gknd 12174 8 by by IN cord-010119-t1x9gknd 12174 9 the the DT cord-010119-t1x9gknd 12174 10 VISION vision NN cord-010119-t1x9gknd 12174 11 ( ( -LRB- cord-010119-t1x9gknd 12174 12 Ortho Ortho NNP cord-010119-t1x9gknd 12174 13 Clinical Clinical NNP cord-010119-t1x9gknd 12174 14 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 12174 15 . . . cord-010119-t1x9gknd 12175 1 Raritan Raritan NNP cord-010119-t1x9gknd 12175 2 , , , cord-010119-t1x9gknd 12175 3 NJ NJ NNP cord-010119-t1x9gknd 12175 4 ) ) -RRB- cord-010119-t1x9gknd 12175 5 , , , cord-010119-t1x9gknd 12175 6 NEO NEO NNP cord-010119-t1x9gknd 12175 7 ( ( -LRB- cord-010119-t1x9gknd 12175 8 Immucor Immucor NNP cord-010119-t1x9gknd 12175 9 . . . cord-010119-t1x9gknd 12175 10 Norcross Norcross NNP cord-010119-t1x9gknd 12175 11 , , , cord-010119-t1x9gknd 12175 12 GA GA NNP cord-010119-t1x9gknd 12175 13 ) ) -RRB- cord-010119-t1x9gknd 12175 14 , , , cord-010119-t1x9gknd 12175 15 and and CC cord-010119-t1x9gknd 12175 16 by by IN cord-010119-t1x9gknd 12175 17 standard standard JJ cord-010119-t1x9gknd 12175 18 ABO ABO NNP cord-010119-t1x9gknd 12175 19 / / SYM cord-010119-t1x9gknd 12175 20 Rh Rh NNP cord-010119-t1x9gknd 12175 21 manual manual NN cord-010119-t1x9gknd 12175 22 testing testing NN cord-010119-t1x9gknd 12175 23 ( ( -LRB- cord-010119-t1x9gknd 12175 24 anti anti JJ cord-010119-t1x9gknd 12175 25 - - JJ cord-010119-t1x9gknd 12175 26 A a JJ cord-010119-t1x9gknd 12175 27 , , , cord-010119-t1x9gknd 12175 28 Anti Anti NNP cord-010119-t1x9gknd 12175 29 - - NNP cord-010119-t1x9gknd 12175 30 B B NNP cord-010119-t1x9gknd 12175 31 , , , cord-010119-t1x9gknd 12175 32 Anti Anti NNP cord-010119-t1x9gknd 12175 33 - - NNP cord-010119-t1x9gknd 12175 34 D D NNP cord-010119-t1x9gknd 12175 35 Series Series NNP cord-010119-t1x9gknd 12175 36 4 4 CD cord-010119-t1x9gknd 12175 37 , , , cord-010119-t1x9gknd 12175 38 Anti Anti NNP cord-010119-t1x9gknd 12175 39 - - NNP cord-010119-t1x9gknd 12175 40 D D NNP cord-010119-t1x9gknd 12175 41 Series Series NNP cord-010119-t1x9gknd 12175 42 5 5 CD cord-010119-t1x9gknd 12175 43 , , , cord-010119-t1x9gknd 12175 44 A1 a1 NN cord-010119-t1x9gknd 12175 45 cell cell NN cord-010119-t1x9gknd 12175 46 and and CC cord-010119-t1x9gknd 12175 47 B b NN cord-010119-t1x9gknd 12175 48 cells cell NNS cord-010119-t1x9gknd 12175 49 . . . cord-010119-t1x9gknd 12176 1 Immucor Immucor NNP cord-010119-t1x9gknd 12176 2 . . . cord-010119-t1x9gknd 12177 1 Norcross Norcross NNP cord-010119-t1x9gknd 12177 2 , , , cord-010119-t1x9gknd 12177 3 GA GA NNP cord-010119-t1x9gknd 12177 4 ) ) -RRB- cord-010119-t1x9gknd 12177 5 . . . cord-010119-t1x9gknd 12178 1 The the DT cord-010119-t1x9gknd 12178 2 repeat repeat NN cord-010119-t1x9gknd 12178 3 testing testing NN cord-010119-t1x9gknd 12178 4 was be VBD cord-010119-t1x9gknd 12178 5 compared compare VBN cord-010119-t1x9gknd 12178 6 to to TO cord-010119-t1x9gknd 12178 7 verify verify VB cord-010119-t1x9gknd 12178 8 the the DT cord-010119-t1x9gknd 12178 9 patient patient NN cord-010119-t1x9gknd 12178 10 's 's POS cord-010119-t1x9gknd 12178 11 ABO ABO NNP cord-010119-t1x9gknd 12178 12 / / SYM cord-010119-t1x9gknd 12178 13 Rh Rh NNP cord-010119-t1x9gknd 12178 14 typing typing NN cord-010119-t1x9gknd 12178 15 and and CC cord-010119-t1x9gknd 12178 16 the the DT cord-010119-t1x9gknd 12178 17 results result NNS cord-010119-t1x9gknd 12178 18 were be VBD cord-010119-t1x9gknd 12178 19 entered enter VBN cord-010119-t1x9gknd 12178 20 into into IN cord-010119-t1x9gknd 12178 21 the the DT cord-010119-t1x9gknd 12178 22 computer computer NN cord-010119-t1x9gknd 12178 23 system system NN cord-010119-t1x9gknd 12178 24 to to TO cord-010119-t1x9gknd 12178 25 allow allow VB cord-010119-t1x9gknd 12178 26 for for IN cord-010119-t1x9gknd 12178 27 assigning assign VBG cord-010119-t1x9gknd 12178 28 the the DT cord-010119-t1x9gknd 12178 29 patient patient NN cord-010119-t1x9gknd 12178 30 's 's POS cord-010119-t1x9gknd 12178 31 ABO ABO NNP cord-010119-t1x9gknd 12178 32 / / SYM cord-010119-t1x9gknd 12178 33 Rh Rh NNP cord-010119-t1x9gknd 12178 34 typing typing NN cord-010119-t1x9gknd 12178 35 and and CC cord-010119-t1x9gknd 12178 36 electronic electronic JJ cord-010119-t1x9gknd 12178 37 crossmatch crossmatch NN cord-010119-t1x9gknd 12178 38 . . . cord-010119-t1x9gknd 12179 1 Results/ Results/ . cord-010119-t1x9gknd 12180 1 Finding finding NN cord-010119-t1x9gknd 12180 2 : : : cord-010119-t1x9gknd 12181 1 Table table NN cord-010119-t1x9gknd 12181 2 1 1 CD cord-010119-t1x9gknd 12181 3 summarizes summarize VBZ cord-010119-t1x9gknd 12181 4 the the DT cord-010119-t1x9gknd 12181 5 initial initial JJ cord-010119-t1x9gknd 12181 6 and and CC cord-010119-t1x9gknd 12181 7 repeat repeat VB cord-010119-t1x9gknd 12181 8 testing testing NN cord-010119-t1x9gknd 12181 9 with with IN cord-010119-t1x9gknd 12181 10 the the DT cord-010119-t1x9gknd 12181 11 two two CD cord-010119-t1x9gknd 12181 12 patient patient NN cord-010119-t1x9gknd 12181 13 samples sample NNS cord-010119-t1x9gknd 12181 14 . . . cord-010119-t1x9gknd 12182 1 Although although IN cord-010119-t1x9gknd 12182 2 the the DT cord-010119-t1x9gknd 12182 3 ECHO ECHO NNP cord-010119-t1x9gknd 12182 4 failed fail VBD cord-010119-t1x9gknd 12182 5 to to TO cord-010119-t1x9gknd 12182 6 interpret interpret VB cord-010119-t1x9gknd 12182 7 or or CC cord-010119-t1x9gknd 12182 8 flag flag VB cord-010119-t1x9gknd 12182 9 the the DT cord-010119-t1x9gknd 12182 10 blood blood NN cord-010119-t1x9gknd 12182 11 type type NN cord-010119-t1x9gknd 12182 12 as as IN cord-010119-t1x9gknd 12182 13 mixed mix VBN cord-010119-t1x9gknd 12182 14 - - HYPH cord-010119-t1x9gknd 12182 15 field field NN cord-010119-t1x9gknd 12182 16 , , , cord-010119-t1x9gknd 12182 17 the the DT cord-010119-t1x9gknd 12182 18 other other JJ cord-010119-t1x9gknd 12182 19 methods method NNS cord-010119-t1x9gknd 12182 20 identified identify VBD cord-010119-t1x9gknd 12182 21 the the DT cord-010119-t1x9gknd 12182 22 transfusion transfusion NN cord-010119-t1x9gknd 12182 23 of of IN cord-010119-t1x9gknd 12182 24 O o NN cord-010119-t1x9gknd 12182 25 , , , cord-010119-t1x9gknd 12182 26 D D NNP cord-010119-t1x9gknd 12182 27 Negative negative JJ cord-010119-t1x9gknd 12182 28 blood blood NN cord-010119-t1x9gknd 12182 29 with with IN cord-010119-t1x9gknd 12182 30 the the DT cord-010119-t1x9gknd 12182 31 detection detection NN cord-010119-t1x9gknd 12182 32 of of IN cord-010119-t1x9gknd 12182 33 mixed mixed JJ cord-010119-t1x9gknd 12182 34 - - HYPH cord-010119-t1x9gknd 12182 35 field field NN cord-010119-t1x9gknd 12182 36 in in IN cord-010119-t1x9gknd 12182 37 the the DT cord-010119-t1x9gknd 12182 38 D d NN cord-010119-t1x9gknd 12182 39 typing typing NN cord-010119-t1x9gknd 12182 40 or or CC cord-010119-t1x9gknd 12182 41 by by IN cord-010119-t1x9gknd 12182 42 failing fail VBG cord-010119-t1x9gknd 12182 43 to to TO cord-010119-t1x9gknd 12182 44 interpret interpret VB cord-010119-t1x9gknd 12182 45 the the DT cord-010119-t1x9gknd 12182 46 ABO ABO NNP cord-010119-t1x9gknd 12182 47 / / SYM cord-010119-t1x9gknd 12182 48 Rh Rh NNP cord-010119-t1x9gknd 12182 49 as as IN cord-010119-t1x9gknd 12182 50 not not RB cord-010119-t1x9gknd 12182 51 type type NN cord-010119-t1x9gknd 12182 52 determined determine VBN cord-010119-t1x9gknd 12182 53 ( ( -LRB- cord-010119-t1x9gknd 12182 54 NTD NTD NNP cord-010119-t1x9gknd 12182 55 ) ) -RRB- cord-010119-t1x9gknd 12182 56 . . . cord-010119-t1x9gknd 12183 1 The the DT cord-010119-t1x9gknd 12183 2 VISION vision NN cord-010119-t1x9gknd 12183 3 and and CC cord-010119-t1x9gknd 12183 4 manual manual JJ cord-010119-t1x9gknd 12183 5 ABO ABO NNP cord-010119-t1x9gknd 12183 6 / / SYM cord-010119-t1x9gknd 12183 7 Rh Rh NNP cord-010119-t1x9gknd 12183 8 typing type VBG cord-010119-t1x9gknd 12183 9 yielded yield VBD cord-010119-t1x9gknd 12183 10 the the DT cord-010119-t1x9gknd 12183 11 easiest easy JJS cord-010119-t1x9gknd 12183 12 mixed mixed JJ cord-010119-t1x9gknd 12183 13 - - HYPH cord-010119-t1x9gknd 12183 14 field field NN cord-010119-t1x9gknd 12183 15 to to TO cord-010119-t1x9gknd 12183 16 interpret interpret VB cord-010119-t1x9gknd 12183 17 macroscopically macroscopically RB cord-010119-t1x9gknd 12183 18 . . . cord-010119-t1x9gknd 12184 1 Conclusion conclusion NN cord-010119-t1x9gknd 12184 2 : : : cord-010119-t1x9gknd 12185 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12185 2 results result NNS cord-010119-t1x9gknd 12185 3 agree agree VBP cord-010119-t1x9gknd 12185 4 with with IN cord-010119-t1x9gknd 12185 5 the the DT cord-010119-t1x9gknd 12185 6 findings finding NNS cord-010119-t1x9gknd 12185 7 of of IN cord-010119-t1x9gknd 12185 8 Summers Summers NNPS cord-010119-t1x9gknd 12185 9 et et NNP cord-010119-t1x9gknd 12185 10 al al NNP cord-010119-t1x9gknd 12185 11 ( ( -LRB- cord-010119-t1x9gknd 12185 12 TRANS TRANS NNP cord-010119-t1x9gknd 12185 13 - - HYPH cord-010119-t1x9gknd 12185 14 FUSION FUSION NNP cord-010119-t1x9gknd 12185 15 2009 2009 CD cord-010119-t1x9gknd 12185 16 ; ; : cord-010119-t1x9gknd 12185 17 49:1672 49:1672 CD cord-010119-t1x9gknd 12185 18 -1677 -1677 : cord-010119-t1x9gknd 12185 19 who who WP cord-010119-t1x9gknd 12185 20 reported report VBD cord-010119-t1x9gknd 12185 21 the the DT cord-010119-t1x9gknd 12185 22 challenge challenge NN cord-010119-t1x9gknd 12185 23 detection detection NN cord-010119-t1x9gknd 12185 24 of of IN cord-010119-t1x9gknd 12185 25 mixed mixed JJ cord-010119-t1x9gknd 12185 26 - - HYPH cord-010119-t1x9gknd 12185 27 field field NN cord-010119-t1x9gknd 12185 28 with with IN cord-010119-t1x9gknd 12185 29 the the DT cord-010119-t1x9gknd 12185 30 use use NN cord-010119-t1x9gknd 12185 31 of of IN cord-010119-t1x9gknd 12185 32 the the DT cord-010119-t1x9gknd 12185 33 ECHO echo NN cord-010119-t1x9gknd 12185 34 compared compare VBN cord-010119-t1x9gknd 12185 35 to to IN cord-010119-t1x9gknd 12185 36 improved improve VBN cord-010119-t1x9gknd 12185 37 detected detect VBN cord-010119-t1x9gknd 12185 38 with with IN cord-010119-t1x9gknd 12185 39 automated automate VBN cord-010119-t1x9gknd 12185 40 gel gel NN cord-010119-t1x9gknd 12185 41 column column NN cord-010119-t1x9gknd 12185 42 agglutination agglutination NN cord-010119-t1x9gknd 12185 43 . . . cord-010119-t1x9gknd 12186 1 When when WRB cord-010119-t1x9gknd 12186 2 the the DT cord-010119-t1x9gknd 12186 3 samples sample NNS cord-010119-t1x9gknd 12186 4 were be VBD cord-010119-t1x9gknd 12186 5 tested test VBN cord-010119-t1x9gknd 12186 6 by by IN cord-010119-t1x9gknd 12186 7 multiple multiple JJ cord-010119-t1x9gknd 12186 8 automated automate VBN cord-010119-t1x9gknd 12186 9 and and CC cord-010119-t1x9gknd 12186 10 manual manual JJ cord-010119-t1x9gknd 12186 11 ABO ABO NNP cord-010119-t1x9gknd 12186 12 / / SYM cord-010119-t1x9gknd 12186 13 Rh Rh NNP cord-010119-t1x9gknd 12186 14 methods method NNS cord-010119-t1x9gknd 12186 15 , , , cord-010119-t1x9gknd 12186 16 the the DT cord-010119-t1x9gknd 12186 17 expected expect VBN cord-010119-t1x9gknd 12186 18 mixed mixed JJ cord-010119-t1x9gknd 12186 19 - - HYPH cord-010119-t1x9gknd 12186 20 field field NN cord-010119-t1x9gknd 12186 21 was be VBD cord-010119-t1x9gknd 12186 22 detected detect VBN cord-010119-t1x9gknd 12186 23 . . . cord-010119-t1x9gknd 12187 1 The the DT cord-010119-t1x9gknd 12187 2 failure failure NN cord-010119-t1x9gknd 12187 3 of of IN cord-010119-t1x9gknd 12187 4 the the DT cord-010119-t1x9gknd 12187 5 ECHO echo NN cord-010119-t1x9gknd 12187 6 to to TO cord-010119-t1x9gknd 12187 7 detect detect VB cord-010119-t1x9gknd 12187 8 the the DT cord-010119-t1x9gknd 12187 9 mixed mixed JJ cord-010119-t1x9gknd 12187 10 - - HYPH cord-010119-t1x9gknd 12187 11 field field NN cord-010119-t1x9gknd 12187 12 is be VBZ cord-010119-t1x9gknd 12187 13 acknowledged acknowledge VBN cord-010119-t1x9gknd 12187 14 by by IN cord-010119-t1x9gknd 12187 15 manufacturer manufacturer NN cord-010119-t1x9gknd 12187 16 , , , cord-010119-t1x9gknd 12187 17 but but CC cord-010119-t1x9gknd 12187 18 there there EX cord-010119-t1x9gknd 12187 19 is be VBZ cord-010119-t1x9gknd 12187 20 a a DT cord-010119-t1x9gknd 12187 21 risk risk NN cord-010119-t1x9gknd 12187 22 that that IN cord-010119-t1x9gknd 12187 23 a a DT cord-010119-t1x9gknd 12187 24 facility facility NN cord-010119-t1x9gknd 12187 25 may may MD cord-010119-t1x9gknd 12187 26 mistype mistype VB cord-010119-t1x9gknd 12187 27 the the DT cord-010119-t1x9gknd 12187 28 ABO ABO NNP cord-010119-t1x9gknd 12187 29 / / SYM cord-010119-t1x9gknd 12187 30 Rh Rh NNP cord-010119-t1x9gknd 12187 31 when when WRB cord-010119-t1x9gknd 12187 32 there there EX cord-010119-t1x9gknd 12187 33 is be VBZ cord-010119-t1x9gknd 12187 34 not not RB cord-010119-t1x9gknd 12187 35 a a DT cord-010119-t1x9gknd 12187 36 historical historical JJ cord-010119-t1x9gknd 12187 37 ABO ABO NNP cord-010119-t1x9gknd 12187 38 / / SYM cord-010119-t1x9gknd 12187 39 Rh Rh NNP cord-010119-t1x9gknd 12187 40 to to TO cord-010119-t1x9gknd 12187 41 compare compare VB cord-010119-t1x9gknd 12187 42 . . . cord-010119-t1x9gknd 12188 1 To to TO cord-010119-t1x9gknd 12188 2 avoid avoid VB cord-010119-t1x9gknd 12188 3 this this DT cord-010119-t1x9gknd 12188 4 risk risk NN cord-010119-t1x9gknd 12188 5 , , , cord-010119-t1x9gknd 12188 6 it -PRON- PRP cord-010119-t1x9gknd 12188 7 may may MD cord-010119-t1x9gknd 12188 8 be be VB cord-010119-t1x9gknd 12188 9 appropriate appropriate JJ cord-010119-t1x9gknd 12188 10 to to TO cord-010119-t1x9gknd 12188 11 re re VB cord-010119-t1x9gknd 12188 12 - - NN cord-010119-t1x9gknd 12188 13 type type JJ cord-010119-t1x9gknd 12188 14 first first JJ cord-010119-t1x9gknd 12188 15 time time NN cord-010119-t1x9gknd 12188 16 SCD SCD NNP cord-010119-t1x9gknd 12188 17 patients patient NNS cord-010119-t1x9gknd 12188 18 by by IN cord-010119-t1x9gknd 12188 19 other other JJ cord-010119-t1x9gknd 12188 20 methods method NNS cord-010119-t1x9gknd 12188 21 rather rather RB cord-010119-t1x9gknd 12188 22 than than IN cord-010119-t1x9gknd 12188 23 the the DT cord-010119-t1x9gknd 12188 24 ECHO ECHO NNP cord-010119-t1x9gknd 12188 25 to to TO cord-010119-t1x9gknd 12188 26 avoid avoid VB cord-010119-t1x9gknd 12188 27 this this DT cord-010119-t1x9gknd 12188 28 challenge challenge NN cord-010119-t1x9gknd 12188 29 . . . cord-010119-t1x9gknd 12189 1 Consistent consistent JJ cord-010119-t1x9gknd 12189 2 with with IN cord-010119-t1x9gknd 12189 3 Summers Summers NNPS cord-010119-t1x9gknd 12189 4 do do VBP cord-010119-t1x9gknd 12189 5 not not RB cord-010119-t1x9gknd 12189 6 account account VB cord-010119-t1x9gknd 12189 7 for for IN cord-010119-t1x9gknd 12189 8 regional regional JJ cord-010119-t1x9gknd 12189 9 distribution distribution NN cord-010119-t1x9gknd 12189 10 . . . cord-010119-t1x9gknd 12190 1 Many many JJ cord-010119-t1x9gknd 12190 2 large large JJ cord-010119-t1x9gknd 12190 3 hospitals hospital NNS cord-010119-t1x9gknd 12190 4 acting act VBG cord-010119-t1x9gknd 12190 5 as as IN cord-010119-t1x9gknd 12190 6 regional regional JJ cord-010119-t1x9gknd 12190 7 hubs hub NNS cord-010119-t1x9gknd 12190 8 for for IN cord-010119-t1x9gknd 12190 9 redistribution redistribution NN cord-010119-t1x9gknd 12190 10 may may MD cord-010119-t1x9gknd 12190 11 appear appear VB cord-010119-t1x9gknd 12190 12 to to TO cord-010119-t1x9gknd 12190 13 have have VB cord-010119-t1x9gknd 12190 14 optimized optimize VBN cord-010119-t1x9gknd 12190 15 inventory inventory NN cord-010119-t1x9gknd 12190 16 based base VBN cord-010119-t1x9gknd 12190 17 on on IN cord-010119-t1x9gknd 12190 18 ODR ODR NNP cord-010119-t1x9gknd 12190 19 and and CC cord-010119-t1x9gknd 12190 20 BSR BSR NNP cord-010119-t1x9gknd 12190 21 , , , cord-010119-t1x9gknd 12190 22 but but CC cord-010119-t1x9gknd 12190 23 we -PRON- PRP cord-010119-t1x9gknd 12190 24 hypothesized hypothesize VBD cord-010119-t1x9gknd 12190 25 that that IN cord-010119-t1x9gknd 12190 26 these these DT cord-010119-t1x9gknd 12190 27 are be VBP cord-010119-t1x9gknd 12190 28 crude crude JJ cord-010119-t1x9gknd 12190 29 key key JJ cord-010119-t1x9gknd 12190 30 performance performance NN cord-010119-t1x9gknd 12190 31 indicators indicator NNS cord-010119-t1x9gknd 12190 32 ( ( -LRB- cord-010119-t1x9gknd 12190 33 KPIs kpi NNS cord-010119-t1x9gknd 12190 34 ) ) -RRB- cord-010119-t1x9gknd 12190 35 requiring require VBG cord-010119-t1x9gknd 12190 36 redevelopment redevelopment NN cord-010119-t1x9gknd 12190 37 . . . cord-010119-t1x9gknd 12191 1 Study Study NNP cord-010119-t1x9gknd 12191 2 Design Design NNP cord-010119-t1x9gknd 12191 3 / / SYM cord-010119-t1x9gknd 12191 4 Method method NN cord-010119-t1x9gknd 12191 5 : : : cord-010119-t1x9gknd 12192 1 KPI KPI NNP cord-010119-t1x9gknd 12192 2 redevelopment redevelopment NN cord-010119-t1x9gknd 12192 3 occurred occur VBD cord-010119-t1x9gknd 12192 4 in in IN cord-010119-t1x9gknd 12192 5 a a DT cord-010119-t1x9gknd 12192 6 large large JJ cord-010119-t1x9gknd 12192 7 tertiary tertiary JJ cord-010119-t1x9gknd 12192 8 care care NN cord-010119-t1x9gknd 12192 9 hospital hospital NN cord-010119-t1x9gknd 12192 10 blood blood NN cord-010119-t1x9gknd 12192 11 bank bank NN cord-010119-t1x9gknd 12192 12 in in IN cord-010119-t1x9gknd 12192 13 Canada Canada NNP cord-010119-t1x9gknd 12192 14 , , , cord-010119-t1x9gknd 12192 15 responsible responsible JJ cord-010119-t1x9gknd 12192 16 for for IN cord-010119-t1x9gknd 12192 17 75 75 CD cord-010119-t1x9gknd 12192 18 % % NN cord-010119-t1x9gknd 12192 19 and and CC cord-010119-t1x9gknd 12192 20 20 20 CD cord-010119-t1x9gknd 12192 21 % % NN cord-010119-t1x9gknd 12192 22 of of IN cord-010119-t1x9gknd 12192 23 transfusions transfusion NNS cord-010119-t1x9gknd 12192 24 in in IN cord-010119-t1x9gknd 12192 25 the the DT cord-010119-t1x9gknd 12192 26 region region NN cord-010119-t1x9gknd 12192 27 and and CC cord-010119-t1x9gknd 12192 28 province province NN cord-010119-t1x9gknd 12192 29 respectively respectively RB cord-010119-t1x9gknd 12192 30 . . . cord-010119-t1x9gknd 12193 1 RBC RBC NNP cord-010119-t1x9gknd 12193 2 supply supply NN cord-010119-t1x9gknd 12193 3 , , , cord-010119-t1x9gknd 12193 4 inventory inventory NN cord-010119-t1x9gknd 12193 5 , , , cord-010119-t1x9gknd 12193 6 and and CC cord-010119-t1x9gknd 12193 7 disposition disposition NN cord-010119-t1x9gknd 12193 8 data datum NNS cord-010119-t1x9gknd 12193 9 were be VBD cord-010119-t1x9gknd 12193 10 retrospectively retrospectively RB cord-010119-t1x9gknd 12193 11 assessed assess VBN cord-010119-t1x9gknd 12193 12 from from IN cord-010119-t1x9gknd 12193 13 February February NNP cord-010119-t1x9gknd 12193 14 2014-June 2014-june CD cord-010119-t1x9gknd 12193 15 2015 2015 CD cord-010119-t1x9gknd 12193 16 as as IN cord-010119-t1x9gknd 12193 17 the the DT cord-010119-t1x9gknd 12193 18 baseline baseline JJ cord-010119-t1x9gknd 12193 19 period period NN cord-010119-t1x9gknd 12193 20 . . . cord-010119-t1x9gknd 12194 1 A a DT cord-010119-t1x9gknd 12194 2 " " `` cord-010119-t1x9gknd 12194 3 demand demand NN cord-010119-t1x9gknd 12194 4 - - HYPH cord-010119-t1x9gknd 12194 5 driven drive VBN cord-010119-t1x9gknd 12194 6 inventory inventory NN cord-010119-t1x9gknd 12194 7 planning planning NN cord-010119-t1x9gknd 12194 8 policy policy NN cord-010119-t1x9gknd 12194 9 " " '' cord-010119-t1x9gknd 12194 10 ( ( -LRB- cord-010119-t1x9gknd 12194 11 DDIP DDIP NNP cord-010119-t1x9gknd 12194 12 ) ) -RRB- cord-010119-t1x9gknd 12194 13 was be VBD cord-010119-t1x9gknd 12194 14 instituted institute VBN cord-010119-t1x9gknd 12194 15 to to TO cord-010119-t1x9gknd 12194 16 assess assess VB cord-010119-t1x9gknd 12194 17 and and CC cord-010119-t1x9gknd 12194 18 implement implement VB cord-010119-t1x9gknd 12194 19 the the DT cord-010119-t1x9gknd 12194 20 optimal optimal JJ cord-010119-t1x9gknd 12194 21 RBC RBC NNP cord-010119-t1x9gknd 12194 22 reorder reorder VB cord-010119-t1x9gknd 12194 23 quantity quantity NN cord-010119-t1x9gknd 12194 24 based base VBN cord-010119-t1x9gknd 12194 25 on on IN cord-010119-t1x9gknd 12194 26 the the DT cord-010119-t1x9gknd 12194 27 difference difference NN cord-010119-t1x9gknd 12194 28 between between IN cord-010119-t1x9gknd 12194 29 the the DT cord-010119-t1x9gknd 12194 30 historical historical JJ cord-010119-t1x9gknd 12194 31 maximum maximum NN cord-010119-t1x9gknd 12194 32 and and CC cord-010119-t1x9gknd 12194 33 minimum minimum JJ cord-010119-t1x9gknd 12194 34 RBC RBC NNP cord-010119-t1x9gknd 12194 35 inventories inventory NNS cord-010119-t1x9gknd 12194 36 during during IN cord-010119-t1x9gknd 12194 37 weekdays weekday NNS cord-010119-t1x9gknd 12194 38 ; ; : cord-010119-t1x9gknd 12194 39 that that DT cord-010119-t1x9gknd 12194 40 would would MD cord-010119-t1x9gknd 12194 41 not not RB cord-010119-t1x9gknd 12194 42 lead lead VB cord-010119-t1x9gknd 12194 43 to to IN cord-010119-t1x9gknd 12194 44 blood blood NN cord-010119-t1x9gknd 12194 45 shortages shortage NNS cord-010119-t1x9gknd 12194 46 . . . cord-010119-t1x9gknd 12195 1 Shelflife shelflife NN cord-010119-t1x9gknd 12195 2 inventory inventory NN cord-010119-t1x9gknd 12195 3 ( ( -LRB- cord-010119-t1x9gknd 12195 4 SLI SLI NNP cord-010119-t1x9gknd 12195 5 ) ) -RRB- cord-010119-t1x9gknd 12195 6 was be VBD cord-010119-t1x9gknd 12195 7 chosen choose VBN cord-010119-t1x9gknd 12195 8 as as IN cord-010119-t1x9gknd 12195 9 the the DT cord-010119-t1x9gknd 12195 10 main main JJ cord-010119-t1x9gknd 12195 11 surrogate surrogate NN cord-010119-t1x9gknd 12195 12 marker marker NN cord-010119-t1x9gknd 12195 13 for for IN cord-010119-t1x9gknd 12195 14 the the DT cord-010119-t1x9gknd 12195 15 assessment assessment NN cord-010119-t1x9gknd 12195 16 of of IN cord-010119-t1x9gknd 12195 17 efficiency efficiency NN cord-010119-t1x9gknd 12195 18 of of IN cord-010119-t1x9gknd 12195 19 the the DT cord-010119-t1x9gknd 12195 20 supply supply NN cord-010119-t1x9gknd 12195 21 chain chain NN cord-010119-t1x9gknd 12195 22 process process NN cord-010119-t1x9gknd 12195 23 , , , cord-010119-t1x9gknd 12195 24 calculated calculate VBN cord-010119-t1x9gknd 12195 25 by by IN cord-010119-t1x9gknd 12195 26 the the DT cord-010119-t1x9gknd 12195 27 differences difference NNS cord-010119-t1x9gknd 12195 28 between between IN cord-010119-t1x9gknd 12195 29 age age NN cord-010119-t1x9gknd 12195 30 of of IN cord-010119-t1x9gknd 12195 31 blood blood NN cord-010119-t1x9gknd 12195 32 transfused transfuse VBN cord-010119-t1x9gknd 12195 33 ( ( -LRB- cord-010119-t1x9gknd 12195 34 ABT ABT NNP cord-010119-t1x9gknd 12195 35 ) ) -RRB- cord-010119-t1x9gknd 12195 36 and and CC cord-010119-t1x9gknd 12195 37 received receive VBD cord-010119-t1x9gknd 12195 38 ( ( -LRB- cord-010119-t1x9gknd 12195 39 ABR ABR NNP cord-010119-t1x9gknd 12195 40 ) ) -RRB- cord-010119-t1x9gknd 12195 41 . . . cord-010119-t1x9gknd 12196 1 Iterative iterative JJ cord-010119-t1x9gknd 12196 2 simulation simulation NN cord-010119-t1x9gknd 12196 3 modeling modeling NN cord-010119-t1x9gknd 12196 4 ( ( -LRB- cord-010119-t1x9gknd 12196 5 R R NNP cord-010119-t1x9gknd 12196 6 statistical statistical JJ cord-010119-t1x9gknd 12196 7 software software NN cord-010119-t1x9gknd 12196 8 ) ) -RRB- cord-010119-t1x9gknd 12196 9 was be VBD cord-010119-t1x9gknd 12196 10 then then RB cord-010119-t1x9gknd 12196 11 performed perform VBN cord-010119-t1x9gknd 12196 12 to to TO cord-010119-t1x9gknd 12196 13 optimize optimize VB cord-010119-t1x9gknd 12196 14 SLI SLI NNP cord-010119-t1x9gknd 12196 15 in in IN cord-010119-t1x9gknd 12196 16 a a DT cord-010119-t1x9gknd 12196 17 post post JJ cord-010119-t1x9gknd 12196 18 - - JJ cord-010119-t1x9gknd 12196 19 implementation implementation JJ cord-010119-t1x9gknd 12196 20 period period NN cord-010119-t1x9gknd 12196 21 from from IN cord-010119-t1x9gknd 12196 22 June June NNP cord-010119-t1x9gknd 12196 23 2015-October 2015-october CD cord-010119-t1x9gknd 12196 24 2016 2016 CD cord-010119-t1x9gknd 12196 25 . . . cord-010119-t1x9gknd 12197 1 Results/ Results/ . cord-010119-t1x9gknd 12198 1 Finding finding NN cord-010119-t1x9gknd 12198 2 : : : cord-010119-t1x9gknd 12199 1 Modeling modeling NN cord-010119-t1x9gknd 12199 2 predicted predict VBD cord-010119-t1x9gknd 12199 3 observed observe VBD cord-010119-t1x9gknd 12199 4 RBC RBC NNP cord-010119-t1x9gknd 12199 5 disposition disposition NN cord-010119-t1x9gknd 12199 6 . . . cord-010119-t1x9gknd 12200 1 Through through IN cord-010119-t1x9gknd 12200 2 simulation simulation NN cord-010119-t1x9gknd 12200 3 , , , cord-010119-t1x9gknd 12200 4 optimization optimization NN cord-010119-t1x9gknd 12200 5 of of IN cord-010119-t1x9gknd 12200 6 SLI SLI NNP cord-010119-t1x9gknd 12200 7 was be VBD cord-010119-t1x9gknd 12200 8 found find VBN cord-010119-t1x9gknd 12200 9 to to TO cord-010119-t1x9gknd 12200 10 occur occur VB cord-010119-t1x9gknd 12200 11 by by IN cord-010119-t1x9gknd 12200 12 optimizing optimize VBG cord-010119-t1x9gknd 12200 13 a a DT cord-010119-t1x9gknd 12200 14 set set NN cord-010119-t1x9gknd 12200 15 of of IN cord-010119-t1x9gknd 12200 16 KPIs kpi NNS cord-010119-t1x9gknd 12200 17 for for IN cord-010119-t1x9gknd 12200 18 each each DT cord-010119-t1x9gknd 12200 19 ABO ABO NNP cord-010119-t1x9gknd 12200 20 blood blood NN cord-010119-t1x9gknd 12200 21 group group NN cord-010119-t1x9gknd 12200 22 ( ( -LRB- cord-010119-t1x9gknd 12200 23 Table Table NNP cord-010119-t1x9gknd 12200 24 1 1 CD cord-010119-t1x9gknd 12200 25 ) ) -RRB- cord-010119-t1x9gknd 12200 26 . . . cord-010119-t1x9gknd 12201 1 This this DT cord-010119-t1x9gknd 12201 2 led lead VBD cord-010119-t1x9gknd 12201 3 to to IN cord-010119-t1x9gknd 12201 4 a a DT cord-010119-t1x9gknd 12201 5 reduction reduction NN cord-010119-t1x9gknd 12201 6 in in IN cord-010119-t1x9gknd 12201 7 observed observed JJ cord-010119-t1x9gknd 12201 8 overall overall JJ cord-010119-t1x9gknd 12201 9 SLI SLI NNP cord-010119-t1x9gknd 12201 10 ( ( -LRB- cord-010119-t1x9gknd 12201 11 7.2 7.2 CD cord-010119-t1x9gknd 12201 12 6 6 CD cord-010119-t1x9gknd 12201 13 1.8 1.8 CD cord-010119-t1x9gknd 12201 14 days day NNS cord-010119-t1x9gknd 12201 15 vs vs IN cord-010119-t1x9gknd 12201 16 6.0 6.0 CD cord-010119-t1x9gknd 12201 17 6 6 CD cord-010119-t1x9gknd 12201 18 1.5 1.5 CD cord-010119-t1x9gknd 12201 19 days day NNS cord-010119-t1x9gknd 12201 20 , , , cord-010119-t1x9gknd 12201 21 p<0.01 p<0.01 NNP cord-010119-t1x9gknd 12201 22 ) ) -RRB- cord-010119-t1x9gknd 12201 23 and and CC cord-010119-t1x9gknd 12201 24 ODR ODR NNP cord-010119-t1x9gknd 12201 25 ( ( -LRB- cord-010119-t1x9gknd 12201 26 0.9 0.9 CD cord-010119-t1x9gknd 12201 27 % % NN cord-010119-t1x9gknd 12201 28 vs vs IN cord-010119-t1x9gknd 12201 29 0.5 0.5 CD cord-010119-t1x9gknd 12201 30 % % NN cord-010119-t1x9gknd 12201 31 ) ) -RRB- cord-010119-t1x9gknd 12201 32 . . . cord-010119-t1x9gknd 12202 1 The the DT cord-010119-t1x9gknd 12202 2 BSR BSR NNP cord-010119-t1x9gknd 12202 3 was be VBD cord-010119-t1x9gknd 12202 4 not not RB cord-010119-t1x9gknd 12202 5 significantly significantly RB cord-010119-t1x9gknd 12202 6 increased increase VBN cord-010119-t1x9gknd 12202 7 during during IN cord-010119-t1x9gknd 12202 8 the the DT cord-010119-t1x9gknd 12202 9 postimplementation postimplementation NN cord-010119-t1x9gknd 12202 10 period period NN cord-010119-t1x9gknd 12202 11 . . . cord-010119-t1x9gknd 12203 1 Conclusion conclusion NN cord-010119-t1x9gknd 12203 2 : : : cord-010119-t1x9gknd 12203 3 Optimization optimization NN cord-010119-t1x9gknd 12203 4 using use VBG cord-010119-t1x9gknd 12203 5 simulation simulation NN cord-010119-t1x9gknd 12203 6 modeling modeling NN cord-010119-t1x9gknd 12203 7 of of IN cord-010119-t1x9gknd 12203 8 multiple multiple JJ cord-010119-t1x9gknd 12203 9 factors factor NNS cord-010119-t1x9gknd 12203 10 other other JJ cord-010119-t1x9gknd 12203 11 than than IN cord-010119-t1x9gknd 12203 12 BSR BSR NNP cord-010119-t1x9gknd 12203 13 and and CC cord-010119-t1x9gknd 12203 14 ODR ODR NNP cord-010119-t1x9gknd 12203 15 led lead VBD cord-010119-t1x9gknd 12203 16 to to IN cord-010119-t1x9gknd 12203 17 further further JJ cord-010119-t1x9gknd 12203 18 efficiency efficiency NN cord-010119-t1x9gknd 12203 19 gains gain NNS cord-010119-t1x9gknd 12203 20 in in IN cord-010119-t1x9gknd 12203 21 a a DT cord-010119-t1x9gknd 12203 22 large large JJ cord-010119-t1x9gknd 12203 23 tertiary tertiary JJ cord-010119-t1x9gknd 12203 24 care care NN cord-010119-t1x9gknd 12203 25 hospital hospital NN cord-010119-t1x9gknd 12203 26 blood blood NNP cord-010119-t1x9gknd 12203 27 bank bank NN cord-010119-t1x9gknd 12203 28 . . . cord-010119-t1x9gknd 12204 1 Hospital hospital NN cord-010119-t1x9gknd 12204 2 blood blood NN cord-010119-t1x9gknd 12204 3 banks bank NNS cord-010119-t1x9gknd 12204 4 should should MD cord-010119-t1x9gknd 12204 5 use use VB cord-010119-t1x9gknd 12204 6 an an DT cord-010119-t1x9gknd 12204 7 integrative integrative JJ cord-010119-t1x9gknd 12204 8 approach approach NN cord-010119-t1x9gknd 12204 9 with with IN cord-010119-t1x9gknd 12204 10 a a DT cord-010119-t1x9gknd 12204 11 set set NN cord-010119-t1x9gknd 12204 12 of of IN cord-010119-t1x9gknd 12204 13 KPIs kpi NNS cord-010119-t1x9gknd 12204 14 to to TO cord-010119-t1x9gknd 12204 15 optimize optimize VB cord-010119-t1x9gknd 12204 16 the the DT cord-010119-t1x9gknd 12204 17 supply supply NN cord-010119-t1x9gknd 12204 18 chain chain NN cord-010119-t1x9gknd 12204 19 . . . cord-010119-t1x9gknd 12205 1 This this DT cord-010119-t1x9gknd 12205 2 approach approach NN cord-010119-t1x9gknd 12205 3 requires require VBZ cord-010119-t1x9gknd 12205 4 validation validation NN cord-010119-t1x9gknd 12205 5 in in IN cord-010119-t1x9gknd 12205 6 other other JJ cord-010119-t1x9gknd 12205 7 blood blood NN cord-010119-t1x9gknd 12205 8 banks bank NNS cord-010119-t1x9gknd 12205 9 and and CC cord-010119-t1x9gknd 12205 10 jurisdictions jurisdiction NNS cord-010119-t1x9gknd 12205 11 . . . cord-010119-t1x9gknd 12206 1 ( ( -LRB- cord-010119-t1x9gknd 12206 2 6 6 LS cord-010119-t1x9gknd 12206 3 ) ) -RRB- cord-010119-t1x9gknd 12206 4 ) ) -RRB- cord-010119-t1x9gknd 12206 5 requires require VBZ cord-010119-t1x9gknd 12206 6 that that IN cord-010119-t1x9gknd 12206 7 the the DT cord-010119-t1x9gknd 12206 8 hospital hospital NN cord-010119-t1x9gknd 12206 9 make make VBP cord-010119-t1x9gknd 12206 10 reasonable reasonable JJ cord-010119-t1x9gknd 12206 11 attempts attempt NNS cord-010119-t1x9gknd 12206 12 to to TO cord-010119-t1x9gknd 12206 13 notify notify VB cord-010119-t1x9gknd 12206 14 the the DT cord-010119-t1x9gknd 12206 15 patient patient NN cord-010119-t1x9gknd 12206 16 ( ( -LRB- cord-010119-t1x9gknd 12206 17 or or CC cord-010119-t1x9gknd 12206 18 the the DT cord-010119-t1x9gknd 12206 19 patient patient NN cord-010119-t1x9gknd 12206 20 's 's POS cord-010119-t1x9gknd 12206 21 physician physician NN cord-010119-t1x9gknd 12206 22 ) ) -RRB- cord-010119-t1x9gknd 12206 23 , , , cord-010119-t1x9gknd 12206 24 counsel counsel VB cord-010119-t1x9gknd 12206 25 the the DT cord-010119-t1x9gknd 12206 26 patient patient NN cord-010119-t1x9gknd 12206 27 , , , cord-010119-t1x9gknd 12206 28 and and CC cord-010119-t1x9gknd 12206 29 offer offer VB cord-010119-t1x9gknd 12206 30 testing testing NN cord-010119-t1x9gknd 12206 31 . . . cord-010119-t1x9gknd 12207 1 The the DT cord-010119-t1x9gknd 12207 2 hospital hospital NN cord-010119-t1x9gknd 12207 3 must must MD cord-010119-t1x9gknd 12207 4 maintain maintain VB cord-010119-t1x9gknd 12207 5 records record NNS cord-010119-t1x9gknd 12207 6 of of IN cord-010119-t1x9gknd 12207 7 this this DT cord-010119-t1x9gknd 12207 8 Lookback Lookback NNP cord-010119-t1x9gknd 12207 9 notification notification NN cord-010119-t1x9gknd 12207 10 as as IN cord-010119-t1x9gknd 12207 11 part part NN cord-010119-t1x9gknd 12207 12 of of IN cord-010119-t1x9gknd 12207 13 the the DT cord-010119-t1x9gknd 12207 14 patient patient NN cord-010119-t1x9gknd 12207 15 's 's POS cord-010119-t1x9gknd 12207 16 medical medical JJ cord-010119-t1x9gknd 12207 17 record record NN cord-010119-t1x9gknd 12207 18 . . . cord-010119-t1x9gknd 12208 1 Paper paper NN cord-010119-t1x9gknd 12208 2 records record NNS cord-010119-t1x9gknd 12208 3 of of IN cord-010119-t1x9gknd 12208 4 Lookback Lookback NNP cord-010119-t1x9gknd 12208 5 notifications notification NNS cord-010119-t1x9gknd 12208 6 are be VBP cord-010119-t1x9gknd 12208 7 less less RBR cord-010119-t1x9gknd 12208 8 accessible accessible JJ cord-010119-t1x9gknd 12208 9 than than IN cord-010119-t1x9gknd 12208 10 electronic electronic JJ cord-010119-t1x9gknd 12208 11 records record NNS cord-010119-t1x9gknd 12208 12 and and CC cord-010119-t1x9gknd 12208 13 are be VBP cord-010119-t1x9gknd 12208 14 at at IN cord-010119-t1x9gknd 12208 15 greater great JJR cord-010119-t1x9gknd 12208 16 risk risk NN cord-010119-t1x9gknd 12208 17 of of IN cord-010119-t1x9gknd 12208 18 being be VBG cord-010119-t1x9gknd 12208 19 damaged damage VBN cord-010119-t1x9gknd 12208 20 or or CC cord-010119-t1x9gknd 12208 21 lost lose VBN cord-010119-t1x9gknd 12208 22 . . . cord-010119-t1x9gknd 12209 1 To to TO cord-010119-t1x9gknd 12209 2 facilitate facilitate VB cord-010119-t1x9gknd 12209 3 the the DT cord-010119-t1x9gknd 12209 4 Lookback Lookback NNP cord-010119-t1x9gknd 12209 5 process process NN cord-010119-t1x9gknd 12209 6 and and CC cord-010119-t1x9gknd 12209 7 reduce reduce VB cord-010119-t1x9gknd 12209 8 paper paper NN cord-010119-t1x9gknd 12209 9 documentation documentation NN cord-010119-t1x9gknd 12209 10 we -PRON- PRP cord-010119-t1x9gknd 12209 11 sought seek VBD cord-010119-t1x9gknd 12209 12 to to TO cord-010119-t1x9gknd 12209 13 use use VB cord-010119-t1x9gknd 12209 14 the the DT cord-010119-t1x9gknd 12209 15 Electronic Electronic NNP cord-010119-t1x9gknd 12209 16 Medical Medical NNP cord-010119-t1x9gknd 12209 17 Record Record NNP cord-010119-t1x9gknd 12209 18 ( ( -LRB- cord-010119-t1x9gknd 12209 19 EMR EMR NNP cord-010119-t1x9gknd 12209 20 ) ) -RRB- cord-010119-t1x9gknd 12209 21 to to TO cord-010119-t1x9gknd 12209 22 perform perform VB cord-010119-t1x9gknd 12209 23 and and CC cord-010119-t1x9gknd 12209 24 document document NN cord-010119-t1x9gknd 12209 25 notifications notification NNS cord-010119-t1x9gknd 12209 26 . . . cord-010119-t1x9gknd 12210 1 Study Study NNP cord-010119-t1x9gknd 12210 2 Design Design NNP cord-010119-t1x9gknd 12210 3 / / SYM cord-010119-t1x9gknd 12210 4 Method method NN cord-010119-t1x9gknd 12210 5 : : : cord-010119-t1x9gknd 12211 1 Representatives representative NNS cord-010119-t1x9gknd 12211 2 from from IN cord-010119-t1x9gknd 12211 3 Transfusion Transfusion NNP cord-010119-t1x9gknd 12211 4 Medicine Medicine NNP cord-010119-t1x9gknd 12211 5 ( ( -LRB- cord-010119-t1x9gknd 12211 6 TM TM NNP cord-010119-t1x9gknd 12211 7 ) ) -RRB- cord-010119-t1x9gknd 12211 8 and and CC cord-010119-t1x9gknd 12211 9 Information Information NNP cord-010119-t1x9gknd 12211 10 Technology Technology NNP cord-010119-t1x9gknd 12211 11 ( ( -LRB- cord-010119-t1x9gknd 12211 12 IT it NN cord-010119-t1x9gknd 12211 13 ) ) -RRB- cord-010119-t1x9gknd 12211 14 worked work VBD cord-010119-t1x9gknd 12211 15 together together RB cord-010119-t1x9gknd 12211 16 to to TO cord-010119-t1x9gknd 12211 17 define define VB cord-010119-t1x9gknd 12211 18 minimum minimum NN cord-010119-t1x9gknd 12211 19 and and CC cord-010119-t1x9gknd 12211 20 optimal optimal JJ cord-010119-t1x9gknd 12211 21 EMR EMR NNP cord-010119-t1x9gknd 12211 22 solutions solution NNS cord-010119-t1x9gknd 12211 23 . . . cord-010119-t1x9gknd 12212 1 Minimally minimally RB cord-010119-t1x9gknd 12212 2 , , , cord-010119-t1x9gknd 12212 3 a a DT cord-010119-t1x9gknd 12212 4 completed complete VBN cord-010119-t1x9gknd 12212 5 paper paper NN cord-010119-t1x9gknd 12212 6 packet packet NN cord-010119-t1x9gknd 12212 7 could could MD cord-010119-t1x9gknd 12212 8 be be VB cord-010119-t1x9gknd 12212 9 scanned scan VBN cord-010119-t1x9gknd 12212 10 into into IN cord-010119-t1x9gknd 12212 11 the the DT cord-010119-t1x9gknd 12212 12 EMR EMR NNP cord-010119-t1x9gknd 12212 13 . . . cord-010119-t1x9gknd 12213 1 This this DT cord-010119-t1x9gknd 12213 2 solution solution NN cord-010119-t1x9gknd 12213 3 had have VBD cord-010119-t1x9gknd 12213 4 no no DT cord-010119-t1x9gknd 12213 5 advantages advantage NNS cord-010119-t1x9gknd 12213 6 in in IN cord-010119-t1x9gknd 12213 7 terms term NNS cord-010119-t1x9gknd 12213 8 of of IN cord-010119-t1x9gknd 12213 9 ease ease NN cord-010119-t1x9gknd 12213 10 of of IN cord-010119-t1x9gknd 12213 11 use use NN cord-010119-t1x9gknd 12213 12 , , , cord-010119-t1x9gknd 12213 13 process process NN cord-010119-t1x9gknd 12213 14 control control NN cord-010119-t1x9gknd 12213 15 , , , cord-010119-t1x9gknd 12213 16 or or CC cord-010119-t1x9gknd 12213 17 transparency transparency NN cord-010119-t1x9gknd 12213 18 . . . cord-010119-t1x9gknd 12214 1 Desired desire VBN cord-010119-t1x9gknd 12214 2 optimal optimal JJ cord-010119-t1x9gknd 12214 3 functionality functionality NN cord-010119-t1x9gknd 12214 4 includes include VBZ cord-010119-t1x9gknd 12214 5 the the DT cord-010119-t1x9gknd 12214 6 ability ability NN cord-010119-t1x9gknd 12214 7 to to TO cord-010119-t1x9gknd 12214 8 send send VB cord-010119-t1x9gknd 12214 9 letters letter NNS cord-010119-t1x9gknd 12214 10 in in IN cord-010119-t1x9gknd 12214 11 the the DT cord-010119-t1x9gknd 12214 12 EMR EMR NNP cord-010119-t1x9gknd 12214 13 , , , cord-010119-t1x9gknd 12214 14 document document NN cord-010119-t1x9gknd 12214 15 control control NN cord-010119-t1x9gknd 12214 16 so so IN cord-010119-t1x9gknd 12214 17 that that IN cord-010119-t1x9gknd 12214 18 original original JJ cord-010119-t1x9gknd 12214 19 communications communication NNS cord-010119-t1x9gknd 12214 20 may may MD cord-010119-t1x9gknd 12214 21 not not RB cord-010119-t1x9gknd 12214 22 be be VB cord-010119-t1x9gknd 12214 23 altered alter VBN cord-010119-t1x9gknd 12214 24 , , , cord-010119-t1x9gknd 12214 25 opportunity opportunity NN cord-010119-t1x9gknd 12214 26 for for IN cord-010119-t1x9gknd 12214 27 patient patient NN cord-010119-t1x9gknd 12214 28 's 's POS cord-010119-t1x9gknd 12214 29 physician physician NN cord-010119-t1x9gknd 12214 30 to to TO cord-010119-t1x9gknd 12214 31 electronically electronically RB cord-010119-t1x9gknd 12214 32 sign sign VB cord-010119-t1x9gknd 12214 33 and and CC cord-010119-t1x9gknd 12214 34 return return VB cord-010119-t1x9gknd 12214 35 responses response NNS cord-010119-t1x9gknd 12214 36 , , , cord-010119-t1x9gknd 12214 37 letter letter NN cord-010119-t1x9gknd 12214 38 and and CC cord-010119-t1x9gknd 12214 39 form form NN cord-010119-t1x9gknd 12214 40 templates template NNS cord-010119-t1x9gknd 12214 41 that that WDT cord-010119-t1x9gknd 12214 42 can can MD cord-010119-t1x9gknd 12214 43 be be VB cord-010119-t1x9gknd 12214 44 individualized individualize VBN cord-010119-t1x9gknd 12214 45 , , , cord-010119-t1x9gknd 12214 46 and and CC cord-010119-t1x9gknd 12214 47 the the DT cord-010119-t1x9gknd 12214 48 ability ability NN cord-010119-t1x9gknd 12214 49 to to TO cord-010119-t1x9gknd 12214 50 track track VB cord-010119-t1x9gknd 12214 51 when when WRB cord-010119-t1x9gknd 12214 52 and and CC cord-010119-t1x9gknd 12214 53 by by IN cord-010119-t1x9gknd 12214 54 whom whom WP cord-010119-t1x9gknd 12214 55 notifications notification NNS cord-010119-t1x9gknd 12214 56 were be VBD cord-010119-t1x9gknd 12214 57 sent send VBN cord-010119-t1x9gknd 12214 58 and and CC cord-010119-t1x9gknd 12214 59 received receive VBN cord-010119-t1x9gknd 12214 60 . . . cord-010119-t1x9gknd 12215 1 The the DT cord-010119-t1x9gknd 12215 2 EMR EMR NNP cord-010119-t1x9gknd 12215 3 system system NN cord-010119-t1x9gknd 12215 4 at at IN cord-010119-t1x9gknd 12215 5 our -PRON- PRP$ cord-010119-t1x9gknd 12215 6 institution institution NN cord-010119-t1x9gknd 12215 7 , , , cord-010119-t1x9gknd 12215 8 Epic Epic NNP cord-010119-t1x9gknd 12215 9 ( ( -LRB- cord-010119-t1x9gknd 12215 10 Epic Epic NNP cord-010119-t1x9gknd 12215 11 Systems Systems NNPS cord-010119-t1x9gknd 12215 12 Corp. Corp. NNP cord-010119-t1x9gknd 12215 13 , , , cord-010119-t1x9gknd 12215 14 Verona Verona NNP cord-010119-t1x9gknd 12215 15 , , , cord-010119-t1x9gknd 12215 16 WI WI NNP cord-010119-t1x9gknd 12215 17 ) ) -RRB- cord-010119-t1x9gknd 12215 18 , , , cord-010119-t1x9gknd 12215 19 has have VBZ cord-010119-t1x9gknd 12215 20 a a DT cord-010119-t1x9gknd 12215 21 function function NN cord-010119-t1x9gknd 12215 22 called call VBN cord-010119-t1x9gknd 12215 23 " " `` cord-010119-t1x9gknd 12215 24 Letters letter NNS cord-010119-t1x9gknd 12215 25 " " '' cord-010119-t1x9gknd 12215 26 with with IN cord-010119-t1x9gknd 12215 27 the the DT cord-010119-t1x9gknd 12215 28 capacity capacity NN cord-010119-t1x9gknd 12215 29 to to TO cord-010119-t1x9gknd 12215 30 do do VB cord-010119-t1x9gknd 12215 31 all all PDT cord-010119-t1x9gknd 12215 32 these these DT cord-010119-t1x9gknd 12215 33 tasks task NNS cord-010119-t1x9gknd 12215 34 . . . cord-010119-t1x9gknd 12216 1 A a DT cord-010119-t1x9gknd 12216 2 series series NN cord-010119-t1x9gknd 12216 3 of of IN cord-010119-t1x9gknd 12216 4 five five CD cord-010119-t1x9gknd 12216 5 templates template NNS cord-010119-t1x9gknd 12216 6 were be VBD cord-010119-t1x9gknd 12216 7 developed develop VBN cord-010119-t1x9gknd 12216 8 : : : cord-010119-t1x9gknd 12216 9 HIV HIV NNP cord-010119-t1x9gknd 12216 10 and and CC cord-010119-t1x9gknd 12216 11 HCV HCV NNP cord-010119-t1x9gknd 12216 12 letters letter NNS cord-010119-t1x9gknd 12216 13 to to IN cord-010119-t1x9gknd 12216 14 physicians physician NNS cord-010119-t1x9gknd 12216 15 , , , cord-010119-t1x9gknd 12216 16 response response NN cord-010119-t1x9gknd 12216 17 forms form NNS cord-010119-t1x9gknd 12216 18 for for IN cord-010119-t1x9gknd 12216 19 physicians physician NNS cord-010119-t1x9gknd 12216 20 to to TO cord-010119-t1x9gknd 12216 21 return return VB cord-010119-t1x9gknd 12216 22 to to IN cord-010119-t1x9gknd 12216 23 the the DT cord-010119-t1x9gknd 12216 24 transfusion transfusion NN cord-010119-t1x9gknd 12216 25 service service NN cord-010119-t1x9gknd 12216 26 , , , cord-010119-t1x9gknd 12216 27 and and CC cord-010119-t1x9gknd 12216 28 a a DT cord-010119-t1x9gknd 12216 29 blank blank JJ cord-010119-t1x9gknd 12216 30 letter letter NN cord-010119-t1x9gknd 12216 31 template template NN cord-010119-t1x9gknd 12216 32 to to TO cord-010119-t1x9gknd 12216 33 be be VB cord-010119-t1x9gknd 12216 34 used use VBN cord-010119-t1x9gknd 12216 35 for for IN cord-010119-t1x9gknd 12216 36 specially specially RB cord-010119-t1x9gknd 12216 37 tailored tailor VBN cord-010119-t1x9gknd 12216 38 letters letter NNS cord-010119-t1x9gknd 12216 39 . . . cord-010119-t1x9gknd 12217 1 Templates template NNS cord-010119-t1x9gknd 12217 2 are be VBP cord-010119-t1x9gknd 12217 3 opened open VBN cord-010119-t1x9gknd 12217 4 within within IN cord-010119-t1x9gknd 12217 5 the the DT cord-010119-t1x9gknd 12217 6 patient patient NN cord-010119-t1x9gknd 12217 7 's 's POS cord-010119-t1x9gknd 12217 8 EMR EMR NNP cord-010119-t1x9gknd 12217 9 and and CC cord-010119-t1x9gknd 12217 10 demographic demographic JJ cord-010119-t1x9gknd 12217 11 information information NN cord-010119-t1x9gknd 12217 12 is be VBZ cord-010119-t1x9gknd 12217 13 automatically automatically RB cord-010119-t1x9gknd 12217 14 populated populate VBN cord-010119-t1x9gknd 12217 15 by by IN cord-010119-t1x9gknd 12217 16 Epic Epic NNP cord-010119-t1x9gknd 12217 17 ( ( -LRB- cord-010119-t1x9gknd 12217 18 eliminating eliminate VBG cord-010119-t1x9gknd 12217 19 many many JJ cord-010119-t1x9gknd 12217 20 possibilities possibility NNS cord-010119-t1x9gknd 12217 21 for for IN cord-010119-t1x9gknd 12217 22 clerical clerical JJ cord-010119-t1x9gknd 12217 23 errors error NNS cord-010119-t1x9gknd 12217 24 ) ) -RRB- cord-010119-t1x9gknd 12217 25 , , , cord-010119-t1x9gknd 12217 26 the the DT cord-010119-t1x9gknd 12217 27 blood blood NN cord-010119-t1x9gknd 12217 28 product product NN cord-010119-t1x9gknd 12217 29 transfused transfuse VBN cord-010119-t1x9gknd 12217 30 ( ( -LRB- cord-010119-t1x9gknd 12217 31 e.g. e.g. JJ cord-010119-t1x9gknd 12217 32 RBCs rbc NNS cord-010119-t1x9gknd 12217 33 or or CC cord-010119-t1x9gknd 12217 34 plasma plasma NN cord-010119-t1x9gknd 12217 35 ) ) -RRB- cord-010119-t1x9gknd 12217 36 is be VBZ cord-010119-t1x9gknd 12217 37 selected select VBN cord-010119-t1x9gknd 12217 38 from from IN cord-010119-t1x9gknd 12217 39 a a DT cord-010119-t1x9gknd 12217 40 drop drop NN cord-010119-t1x9gknd 12217 41 - - HYPH cord-010119-t1x9gknd 12217 42 down down RP cord-010119-t1x9gknd 12217 43 menu menu NN cord-010119-t1x9gknd 12217 44 , , , cord-010119-t1x9gknd 12217 45 and and CC cord-010119-t1x9gknd 12217 46 the the DT cord-010119-t1x9gknd 12217 47 date date NN cord-010119-t1x9gknd 12217 48 of of IN cord-010119-t1x9gknd 12217 49 transfusion transfusion NN cord-010119-t1x9gknd 12217 50 is be VBZ cord-010119-t1x9gknd 12217 51 manually manually RB cord-010119-t1x9gknd 12217 52 entered enter VBN cord-010119-t1x9gknd 12217 53 by by IN cord-010119-t1x9gknd 12217 54 the the DT cord-010119-t1x9gknd 12217 55 sender sender NN cord-010119-t1x9gknd 12217 56 . . . cord-010119-t1x9gknd 12218 1 The the DT cord-010119-t1x9gknd 12218 2 completed complete VBN cord-010119-t1x9gknd 12218 3 letter letter NN cord-010119-t1x9gknd 12218 4 is be VBZ cord-010119-t1x9gknd 12218 5 then then RB cord-010119-t1x9gknd 12218 6 routed route VBN cord-010119-t1x9gknd 12218 7 to to IN cord-010119-t1x9gknd 12218 8 the the DT cord-010119-t1x9gknd 12218 9 patient patient NN cord-010119-t1x9gknd 12218 10 's 's POS cord-010119-t1x9gknd 12218 11 physician physician NN cord-010119-t1x9gknd 12218 12 ; ; : cord-010119-t1x9gknd 12218 13 it -PRON- PRP cord-010119-t1x9gknd 12218 14 shows show VBZ cord-010119-t1x9gknd 12218 15 up up RP cord-010119-t1x9gknd 12218 16 automatically automatically RB cord-010119-t1x9gknd 12218 17 ( ( -LRB- cord-010119-t1x9gknd 12218 18 and and CC cord-010119-t1x9gknd 12218 19 instantly instantly RB cord-010119-t1x9gknd 12218 20 ) ) -RRB- cord-010119-t1x9gknd 12218 21 in in IN cord-010119-t1x9gknd 12218 22 their -PRON- PRP$ cord-010119-t1x9gknd 12218 23 electronic electronic NN cord-010119-t1x9gknd 12218 24 In in IN cord-010119-t1x9gknd 12218 25 Basket Basket NNP cord-010119-t1x9gknd 12218 26 as as RB cord-010119-t1x9gknd 12218 27 well well RB cord-010119-t1x9gknd 12218 28 as as IN cord-010119-t1x9gknd 12218 29 in in IN cord-010119-t1x9gknd 12218 30 the the DT cord-010119-t1x9gknd 12218 31 patient patient NN cord-010119-t1x9gknd 12218 32 's 's POS cord-010119-t1x9gknd 12218 33 EMR EMR NNP cord-010119-t1x9gknd 12218 34 . . . cord-010119-t1x9gknd 12219 1 Physicians physician NNS cord-010119-t1x9gknd 12219 2 may may MD cord-010119-t1x9gknd 12219 3 electronically electronically RB cord-010119-t1x9gknd 12219 4 complete complete VB cord-010119-t1x9gknd 12219 5 and and CC cord-010119-t1x9gknd 12219 6 return return VB cord-010119-t1x9gknd 12219 7 the the DT cord-010119-t1x9gknd 12219 8 response response NN cord-010119-t1x9gknd 12219 9 form form NN cord-010119-t1x9gknd 12219 10 within within IN cord-010119-t1x9gknd 12219 11 Epic Epic NNP cord-010119-t1x9gknd 12219 12 , , , cord-010119-t1x9gknd 12219 13 or or CC cord-010119-t1x9gknd 12219 14 print print VB cord-010119-t1x9gknd 12219 15 it -PRON- PRP cord-010119-t1x9gknd 12219 16 and and CC cord-010119-t1x9gknd 12219 17 return return VB cord-010119-t1x9gknd 12219 18 the the DT cord-010119-t1x9gknd 12219 19 form form NN cord-010119-t1x9gknd 12219 20 by by IN cord-010119-t1x9gknd 12219 21 fax fax NN cord-010119-t1x9gknd 12219 22 . . . cord-010119-t1x9gknd 12220 1 Results/ Results/ . cord-010119-t1x9gknd 12221 1 Finding finding NN cord-010119-t1x9gknd 12221 2 : : : cord-010119-t1x9gknd 12222 1 Between between IN cord-010119-t1x9gknd 12222 2 January January NNP cord-010119-t1x9gknd 12222 3 2014 2014 CD cord-010119-t1x9gknd 12222 4 and and CC cord-010119-t1x9gknd 12222 5 December December NNP cord-010119-t1x9gknd 12222 6 2016 2016 CD cord-010119-t1x9gknd 12222 7 thirty thirty CD cord-010119-t1x9gknd 12222 8 - - HYPH cord-010119-t1x9gknd 12222 9 five five CD cord-010119-t1x9gknd 12222 10 ( ( -LRB- cord-010119-t1x9gknd 12222 11 35 35 CD cord-010119-t1x9gknd 12222 12 ) ) -RRB- cord-010119-t1x9gknd 12222 13 notifications notification NNS cord-010119-t1x9gknd 12222 14 were be VBD cord-010119-t1x9gknd 12222 15 sent send VBN cord-010119-t1x9gknd 12222 16 to to IN cord-010119-t1x9gknd 12222 17 physicians physician NNS cord-010119-t1x9gknd 12222 18 using use VBG cord-010119-t1x9gknd 12222 19 Epic Epic NNP cord-010119-t1x9gknd 12222 20 Letters Letters NNPS cord-010119-t1x9gknd 12222 21 and and CC cord-010119-t1x9gknd 12222 22 of of IN cord-010119-t1x9gknd 12222 23 those those DT cord-010119-t1x9gknd 12223 1 , , , cord-010119-t1x9gknd 12223 2 fourteen fourteen CD cord-010119-t1x9gknd 12223 3 ( ( -LRB- cord-010119-t1x9gknd 12223 4 14 14 CD cord-010119-t1x9gknd 12223 5 ) ) -RRB- cord-010119-t1x9gknd 12223 6 responded respond VBD cord-010119-t1x9gknd 12223 7 to to IN cord-010119-t1x9gknd 12223 8 the the DT cord-010119-t1x9gknd 12223 9 Epic Epic NNP cord-010119-t1x9gknd 12223 10 Notification Notification NNP cord-010119-t1x9gknd 12223 11 and and CC cord-010119-t1x9gknd 12223 12 five five CD cord-010119-t1x9gknd 12223 13 ( ( -LRB- cord-010119-t1x9gknd 12223 14 5 5 CD cord-010119-t1x9gknd 12223 15 ) ) -RRB- cord-010119-t1x9gknd 12223 16 used use VBD cord-010119-t1x9gknd 12223 17 the the DT cord-010119-t1x9gknd 12223 18 provided provide VBN cord-010119-t1x9gknd 12223 19 electronic electronic JJ cord-010119-t1x9gknd 12223 20 response response NN cord-010119-t1x9gknd 12223 21 form form NN cord-010119-t1x9gknd 12223 22 . . . cord-010119-t1x9gknd 12224 1 For for IN cord-010119-t1x9gknd 12224 2 these these DT cord-010119-t1x9gknd 12224 3 cases case NNS cord-010119-t1x9gknd 12224 4 the the DT cord-010119-t1x9gknd 12224 5 time time NN cord-010119-t1x9gknd 12224 6 to to TO cord-010119-t1x9gknd 12224 7 mail mail NN cord-010119-t1x9gknd 12224 8 or or CC cord-010119-t1x9gknd 12224 9 handdeliver handdeliver NNP cord-010119-t1x9gknd 12224 10 paper paper NN cord-010119-t1x9gknd 12224 11 notifications notification NNS cord-010119-t1x9gknd 12224 12 was be VBD cord-010119-t1x9gknd 12224 13 avoided avoid VBN cord-010119-t1x9gknd 12224 14 . . . cord-010119-t1x9gknd 12225 1 The the DT cord-010119-t1x9gknd 12225 2 remaining remain VBG cord-010119-t1x9gknd 12225 3 21 21 CD cord-010119-t1x9gknd 12225 4 cases case NNS cord-010119-t1x9gknd 12225 5 required require VBN cord-010119-t1x9gknd 12225 6 follow follow NN cord-010119-t1x9gknd 12225 7 - - HYPH cord-010119-t1x9gknd 12225 8 up up NN cord-010119-t1x9gknd 12225 9 paper paper NN cord-010119-t1x9gknd 12225 10 notification notification NN cord-010119-t1x9gknd 12225 11 , , , cord-010119-t1x9gknd 12225 12 but but CC cord-010119-t1x9gknd 12225 13 the the DT cord-010119-t1x9gknd 12225 14 electronic electronic JJ cord-010119-t1x9gknd 12225 15 Letter Letter NNP cord-010119-t1x9gknd 12225 16 remains remain VBZ cord-010119-t1x9gknd 12225 17 as as IN cord-010119-t1x9gknd 12225 18 permanent permanent JJ cord-010119-t1x9gknd 12225 19 , , , cord-010119-t1x9gknd 12225 20 easily easily RB cord-010119-t1x9gknd 12225 21 accessible accessible JJ cord-010119-t1x9gknd 12225 22 documentation documentation NN cord-010119-t1x9gknd 12225 23 of of IN cord-010119-t1x9gknd 12225 24 when when WRB cord-010119-t1x9gknd 12225 25 the the DT cord-010119-t1x9gknd 12225 26 transfusion transfusion NN cord-010119-t1x9gknd 12225 27 service service NN cord-010119-t1x9gknd 12225 28 first first RB cord-010119-t1x9gknd 12225 29 notified notify VBD cord-010119-t1x9gknd 12225 30 the the DT cord-010119-t1x9gknd 12225 31 physician physician NN cord-010119-t1x9gknd 12225 32 . . . cord-010119-t1x9gknd 12226 1 Conclusion conclusion NN cord-010119-t1x9gknd 12226 2 : : : cord-010119-t1x9gknd 12227 1 Lookback lookback JJ cord-010119-t1x9gknd 12227 2 notifications notification NNS cord-010119-t1x9gknd 12227 3 within within IN cord-010119-t1x9gknd 12227 4 the the DT cord-010119-t1x9gknd 12227 5 EMR EMR NNP cord-010119-t1x9gknd 12227 6 makes make VBZ cord-010119-t1x9gknd 12227 7 compliance compliance NN cord-010119-t1x9gknd 12227 8 with with IN cord-010119-t1x9gknd 12227 9 government government NN cord-010119-t1x9gknd 12227 10 requirements requirement NNS cord-010119-t1x9gknd 12227 11 more more RBR cord-010119-t1x9gknd 12227 12 transparent transparent JJ cord-010119-t1x9gknd 12227 13 and and CC cord-010119-t1x9gknd 12227 14 records record NNS cord-010119-t1x9gknd 12227 15 more more RBR cord-010119-t1x9gknd 12227 16 accessible accessible JJ cord-010119-t1x9gknd 12227 17 to to IN cord-010119-t1x9gknd 12227 18 caregivers caregiver NNS cord-010119-t1x9gknd 12227 19 , , , cord-010119-t1x9gknd 12227 20 patients patient NNS cord-010119-t1x9gknd 12227 21 , , , cord-010119-t1x9gknd 12227 22 and and CC cord-010119-t1x9gknd 12227 23 assessors assessor NNS cord-010119-t1x9gknd 12227 24 . . . cord-010119-t1x9gknd 12228 1 Secondarily secondarily RB cord-010119-t1x9gknd 12228 2 , , , cord-010119-t1x9gknd 12228 3 efficiency efficiency NN cord-010119-t1x9gknd 12228 4 may may MD cord-010119-t1x9gknd 12228 5 be be VB cord-010119-t1x9gknd 12228 6 improved improve VBN cord-010119-t1x9gknd 12228 7 by by IN cord-010119-t1x9gknd 12228 8 reducing reduce VBG cord-010119-t1x9gknd 12228 9 the the DT cord-010119-t1x9gknd 12228 10 need need NN cord-010119-t1x9gknd 12228 11 to to TO cord-010119-t1x9gknd 12228 12 print print VB cord-010119-t1x9gknd 12228 13 and and CC cord-010119-t1x9gknd 12228 14 mail mail NN cord-010119-t1x9gknd 12228 15 / / SYM cord-010119-t1x9gknd 12228 16 deliver deliver VB cord-010119-t1x9gknd 12228 17 letters letter NNS cord-010119-t1x9gknd 12228 18 . . . cord-010119-t1x9gknd 12229 1 Evaluation evaluation NN cord-010119-t1x9gknd 12229 2 of of IN cord-010119-t1x9gknd 12229 3 Ordering Ordering NNP cord-010119-t1x9gknd 12229 4 Practice Practice NNP cord-010119-t1x9gknd 12229 5 in in IN cord-010119-t1x9gknd 12229 6 the the DT cord-010119-t1x9gknd 12229 7 Operating operate VBG cord-010119-t1x9gknd 12229 8 Rooms room NNS cord-010119-t1x9gknd 12229 9 and and CC cord-010119-t1x9gknd 12229 10 Its -PRON- PRP$ cord-010119-t1x9gknd 12229 11 Impact Impact NNP cord-010119-t1x9gknd 12229 12 on on IN cord-010119-t1x9gknd 12229 13 Product Product NNP cord-010119-t1x9gknd 12229 14 Wastage Wastage NNP cord-010119-t1x9gknd 12229 15 Alexandra Alexandra NNP cord-010119-t1x9gknd 12229 16 Budhai Budhai NNP cord-010119-t1x9gknd 12230 1 * * NFP cord-010119-t1x9gknd 12230 2 1 1 CD cord-010119-t1x9gknd 12230 3 , , , cord-010119-t1x9gknd 12230 4 Denden Denden NNP cord-010119-t1x9gknd 12230 5 Benabdessadek Benabdessadek NNP cord-010119-t1x9gknd 12230 6 2 2 CD cord-010119-t1x9gknd 12230 7 , , , cord-010119-t1x9gknd 12230 8 Annu Annu NNP cord-010119-t1x9gknd 12230 9 George George NNP cord-010119-t1x9gknd 12230 10 2 2 CD cord-010119-t1x9gknd 12230 11 and and CC cord-010119-t1x9gknd 12230 12 Alexandra Alexandra NNP cord-010119-t1x9gknd 12230 13 Jimenez Jimenez NNP cord-010119-t1x9gknd 12230 14 2 2 CD cord-010119-t1x9gknd 12230 15 . . . cord-010119-t1x9gknd 12231 1 1 1 LS cord-010119-t1x9gknd 12232 1 Westchester Westchester NNP cord-010119-t1x9gknd 12232 2 Medical Medical NNP cord-010119-t1x9gknd 12232 3 Center Center NNP cord-010119-t1x9gknd 12232 4 , , , cord-010119-t1x9gknd 12232 5 2 2 CD cord-010119-t1x9gknd 12232 6 New New NNP cord-010119-t1x9gknd 12232 7 York York NNP cord-010119-t1x9gknd 12232 8 Blood Blood NNP cord-010119-t1x9gknd 12232 9 Center Center NNP cord-010119-t1x9gknd 12232 10 Background Background NNP cord-010119-t1x9gknd 12232 11 / / SYM cord-010119-t1x9gknd 12232 12 Case Case NNP cord-010119-t1x9gknd 12232 13 Studies Studies NNPS cord-010119-t1x9gknd 12232 14 : : : cord-010119-t1x9gknd 12232 15 Blood blood NN cord-010119-t1x9gknd 12232 16 product product NN cord-010119-t1x9gknd 12232 17 wastage wastage NN cord-010119-t1x9gknd 12232 18 is be VBZ cord-010119-t1x9gknd 12232 19 an an DT cord-010119-t1x9gknd 12232 20 issue issue NN cord-010119-t1x9gknd 12232 21 that that IN cord-010119-t1x9gknd 12232 22 many many JJ cord-010119-t1x9gknd 12232 23 hospitals hospital NNS cord-010119-t1x9gknd 12232 24 aim aim VBP cord-010119-t1x9gknd 12232 25 to to TO cord-010119-t1x9gknd 12232 26 address address VB cord-010119-t1x9gknd 12232 27 . . . cord-010119-t1x9gknd 12233 1 The the DT cord-010119-t1x9gknd 12233 2 OR OR NNP cord-010119-t1x9gknd 12233 3 was be VBD cord-010119-t1x9gknd 12233 4 identified identify VBN cord-010119-t1x9gknd 12233 5 to to TO cord-010119-t1x9gknd 12233 6 have have VB cord-010119-t1x9gknd 12233 7 the the DT cord-010119-t1x9gknd 12233 8 highest high JJS cord-010119-t1x9gknd 12233 9 rate rate NN cord-010119-t1x9gknd 12233 10 of of IN cord-010119-t1x9gknd 12233 11 wastage wastage NN cord-010119-t1x9gknd 12233 12 within within IN cord-010119-t1x9gknd 12233 13 our -PRON- PRP$ cord-010119-t1x9gknd 12233 14 hospital hospital NN cord-010119-t1x9gknd 12233 15 . . . cord-010119-t1x9gknd 12234 1 In in IN cord-010119-t1x9gknd 12234 2 this this DT cord-010119-t1x9gknd 12234 3 study study NN cord-010119-t1x9gknd 12234 4 , , , cord-010119-t1x9gknd 12234 5 we -PRON- PRP cord-010119-t1x9gknd 12234 6 assessed assess VBD cord-010119-t1x9gknd 12234 7 the the DT cord-010119-t1x9gknd 12234 8 appropriateness appropriateness NN cord-010119-t1x9gknd 12234 9 of of IN cord-010119-t1x9gknd 12234 10 the the DT cord-010119-t1x9gknd 12234 11 product product NN cord-010119-t1x9gknd 12234 12 order order NN cord-010119-t1x9gknd 12234 13 and and CC cord-010119-t1x9gknd 12234 14 utilization utilization NN cord-010119-t1x9gknd 12234 15 by by IN cord-010119-t1x9gknd 12234 16 the the DT cord-010119-t1x9gknd 12234 17 OR OR NNP cord-010119-t1x9gknd 12234 18 to to TO cord-010119-t1x9gknd 12234 19 understand understand VB cord-010119-t1x9gknd 12234 20 its -PRON- PRP$ cord-010119-t1x9gknd 12234 21 impact impact NN cord-010119-t1x9gknd 12234 22 on on IN cord-010119-t1x9gknd 12234 23 wastage wastage NN cord-010119-t1x9gknd 12234 24 . . . cord-010119-t1x9gknd 12235 1 Study Study NNP cord-010119-t1x9gknd 12235 2 Design Design NNP cord-010119-t1x9gknd 12235 3 / / SYM cord-010119-t1x9gknd 12235 4 Methods method NNS cord-010119-t1x9gknd 12235 5 : : : cord-010119-t1x9gknd 12236 1 Data datum NNS cord-010119-t1x9gknd 12236 2 on on IN cord-010119-t1x9gknd 12236 3 product product NN cord-010119-t1x9gknd 12236 4 orders order NNS cord-010119-t1x9gknd 12236 5 , , , cord-010119-t1x9gknd 12236 6 issue issue NN cord-010119-t1x9gknd 12236 7 , , , cord-010119-t1x9gknd 12236 8 and and CC cord-010119-t1x9gknd 12236 9 return return VB cord-010119-t1x9gknd 12236 10 for for IN cord-010119-t1x9gknd 12236 11 two two CD cord-010119-t1x9gknd 12236 12 months month NNS cord-010119-t1x9gknd 12236 13 were be VBD cord-010119-t1x9gknd 12236 14 analyzed analyze VBN cord-010119-t1x9gknd 12236 15 . . . cord-010119-t1x9gknd 12237 1 The the DT cord-010119-t1x9gknd 12237 2 hospital hospital NN cord-010119-t1x9gknd 12237 3 CPOE CPOE NNP cord-010119-t1x9gknd 12237 4 and and CC cord-010119-t1x9gknd 12237 5 product product NN cord-010119-t1x9gknd 12237 6 requisition requisition NN cord-010119-t1x9gknd 12237 7 forms form NNS cord-010119-t1x9gknd 12237 8 were be VBD cord-010119-t1x9gknd 12237 9 used use VBN cord-010119-t1x9gknd 12237 10 to to TO cord-010119-t1x9gknd 12237 11 collect collect VB cord-010119-t1x9gknd 12237 12 this this DT cord-010119-t1x9gknd 12237 13 data datum NNS cord-010119-t1x9gknd 12237 14 . . . cord-010119-t1x9gknd 12238 1 The the DT cord-010119-t1x9gknd 12238 2 surgical surgical JJ cord-010119-t1x9gknd 12238 3 procedures procedure NNS cord-010119-t1x9gknd 12238 4 and and CC cord-010119-t1x9gknd 12238 5 number number NN cord-010119-t1x9gknd 12238 6 of of IN cord-010119-t1x9gknd 12238 7 ordered order VBN cord-010119-t1x9gknd 12238 8 units unit NNS cord-010119-t1x9gknd 12238 9 were be VBD cord-010119-t1x9gknd 12238 10 compared compare VBN cord-010119-t1x9gknd 12238 11 to to IN cord-010119-t1x9gknd 12238 12 the the DT cord-010119-t1x9gknd 12238 13 hospital hospital NN cord-010119-t1x9gknd 12238 14 's 's POS cord-010119-t1x9gknd 12238 15 maximum maximum JJ cord-010119-t1x9gknd 12238 16 surgical surgical JJ cord-010119-t1x9gknd 12238 17 blood blood NN cord-010119-t1x9gknd 12238 18 order order NN cord-010119-t1x9gknd 12238 19 schedule schedule NN cord-010119-t1x9gknd 12238 20 ( ( -LRB- cord-010119-t1x9gknd 12238 21 MSBOS MSBOS NNP cord-010119-t1x9gknd 12238 22 ) ) -RRB- cord-010119-t1x9gknd 12238 23 . . . cord-010119-t1x9gknd 12239 1 Trends trend NNS cord-010119-t1x9gknd 12239 2 for for IN cord-010119-t1x9gknd 12239 3 inappropriate inappropriate JJ cord-010119-t1x9gknd 12239 4 orders order NNS cord-010119-t1x9gknd 12239 5 for for IN cord-010119-t1x9gknd 12239 6 products product NNS cord-010119-t1x9gknd 12239 7 by by IN cord-010119-t1x9gknd 12239 8 physicians physician NNS cord-010119-t1x9gknd 12239 9 were be VBD cord-010119-t1x9gknd 12239 10 evaluated evaluate VBN cord-010119-t1x9gknd 12239 11 . . . cord-010119-t1x9gknd 12240 1 Results result NNS cord-010119-t1x9gknd 12240 2 / / SYM cord-010119-t1x9gknd 12240 3 Findings finding NNS cord-010119-t1x9gknd 12240 4 : : : cord-010119-t1x9gknd 12241 1 A a DT cord-010119-t1x9gknd 12241 2 total total NN cord-010119-t1x9gknd 12241 3 of of IN cord-010119-t1x9gknd 12241 4 941 941 CD cord-010119-t1x9gknd 12241 5 orders order NNS cord-010119-t1x9gknd 12241 6 were be VBD cord-010119-t1x9gknd 12241 7 reviewed review VBN cord-010119-t1x9gknd 12241 8 . . . cord-010119-t1x9gknd 12242 1 Approximately approximately RB cord-010119-t1x9gknd 12242 2 , , , cord-010119-t1x9gknd 12242 3 30 30 CD cord-010119-t1x9gknd 12242 4 % % NN cord-010119-t1x9gknd 12242 5 of of IN cord-010119-t1x9gknd 12242 6 these these DT cord-010119-t1x9gknd 12242 7 products product NNS cord-010119-t1x9gknd 12242 8 were be VBD cord-010119-t1x9gknd 12242 9 issued issue VBN cord-010119-t1x9gknd 12242 10 to to IN cord-010119-t1x9gknd 12242 11 the the DT cord-010119-t1x9gknd 12242 12 OR OR NNP cord-010119-t1x9gknd 12242 13 . . . cord-010119-t1x9gknd 12243 1 We -PRON- PRP cord-010119-t1x9gknd 12243 2 found find VBD cord-010119-t1x9gknd 12243 3 that that IN cord-010119-t1x9gknd 12243 4 the the DT cord-010119-t1x9gknd 12243 5 physician physician NN cord-010119-t1x9gknd 12243 6 orders order NNS cord-010119-t1x9gknd 12243 7 were be VBD cord-010119-t1x9gknd 12243 8 within within IN cord-010119-t1x9gknd 12243 9 the the DT cord-010119-t1x9gknd 12243 10 guidelines guideline NNS cord-010119-t1x9gknd 12243 11 of of IN cord-010119-t1x9gknd 12243 12 the the DT cord-010119-t1x9gknd 12243 13 MSBOS MSBOS NNPS cord-010119-t1x9gknd 12243 14 for for IN cord-010119-t1x9gknd 12243 15 most most JJS cord-010119-t1x9gknd 12243 16 cases case NNS cord-010119-t1x9gknd 12243 17 ( ( -LRB- cord-010119-t1x9gknd 12243 18 89 89 CD cord-010119-t1x9gknd 12243 19 % % NN cord-010119-t1x9gknd 12243 20 ) ) -RRB- cord-010119-t1x9gknd 12243 21 , , , cord-010119-t1x9gknd 12243 22 but but CC cord-010119-t1x9gknd 12243 23 of of IN cord-010119-t1x9gknd 12243 24 the the DT cord-010119-t1x9gknd 12243 25 issued issue VBN cord-010119-t1x9gknd 12243 26 products product NNS cord-010119-t1x9gknd 12243 27 , , , cord-010119-t1x9gknd 12243 28 all all DT cord-010119-t1x9gknd 12243 29 were be VBD cord-010119-t1x9gknd 12243 30 returned return VBN cord-010119-t1x9gknd 12243 31 to to IN cord-010119-t1x9gknd 12243 32 the the DT cord-010119-t1x9gknd 12243 33 blood blood NN cord-010119-t1x9gknd 12243 34 bank bank NN cord-010119-t1x9gknd 12243 35 in in IN cord-010119-t1x9gknd 12243 36 40 40 CD cord-010119-t1x9gknd 12243 37 % % NN cord-010119-t1x9gknd 12243 38 of of IN cord-010119-t1x9gknd 12243 39 cases case NNS cord-010119-t1x9gknd 12243 40 . . . cord-010119-t1x9gknd 12244 1 We -PRON- PRP cord-010119-t1x9gknd 12244 2 observed observe VBD cord-010119-t1x9gknd 12244 3 that that IN cord-010119-t1x9gknd 12244 4 the the DT cord-010119-t1x9gknd 12244 5 percentage percentage NN cord-010119-t1x9gknd 12244 6 of of IN cord-010119-t1x9gknd 12244 7 products product NNS cord-010119-t1x9gknd 12244 8 ordered order VBN cord-010119-t1x9gknd 12244 9 and and CC cord-010119-t1x9gknd 12244 10 used use VBN cord-010119-t1x9gknd 12244 11 compared compare VBN cord-010119-t1x9gknd 12244 12 with with IN cord-010119-t1x9gknd 12244 13 the the DT cord-010119-t1x9gknd 12244 14 products product NNS cord-010119-t1x9gknd 12244 15 ordered order VBN cord-010119-t1x9gknd 12244 16 and and CC cord-010119-t1x9gknd 12244 17 returned return VBD cord-010119-t1x9gknd 12244 18 in in IN cord-010119-t1x9gknd 12244 19 cardiac cardiac JJ cord-010119-t1x9gknd 12244 20 surgeries surgery NNS cord-010119-t1x9gknd 12244 21 are be VBP cord-010119-t1x9gknd 12244 22 nearly nearly RB cord-010119-t1x9gknd 12244 23 equal equal JJ cord-010119-t1x9gknd 12244 24 . . . cord-010119-t1x9gknd 12245 1 In in IN cord-010119-t1x9gknd 12245 2 addition addition NN cord-010119-t1x9gknd 12245 3 , , , cord-010119-t1x9gknd 12245 4 all all DT cord-010119-t1x9gknd 12245 5 of of IN cord-010119-t1x9gknd 12245 6 the the DT cord-010119-t1x9gknd 12245 7 products product NNS cord-010119-t1x9gknd 12245 8 ordered order VBN cord-010119-t1x9gknd 12245 9 for for IN cord-010119-t1x9gknd 12245 10 C c NN cord-010119-t1x9gknd 12245 11 - - HYPH cord-010119-t1x9gknd 12245 12 sections section NNS cord-010119-t1x9gknd 12245 13 were be VBD cord-010119-t1x9gknd 12245 14 not not RB cord-010119-t1x9gknd 12245 15 used use VBN cord-010119-t1x9gknd 12245 16 ; ; : cord-010119-t1x9gknd 12245 17 albeit albeit IN cord-010119-t1x9gknd 12245 18 ordering order VBG cord-010119-t1x9gknd 12245 19 frequency frequency NN cord-010119-t1x9gknd 12245 20 being be VBG cord-010119-t1x9gknd 12245 21 significantly significantly RB cord-010119-t1x9gknd 12245 22 lower low JJR cord-010119-t1x9gknd 12245 23 than than IN cord-010119-t1x9gknd 12245 24 for for IN cord-010119-t1x9gknd 12245 25 cardiac cardiac JJ cord-010119-t1x9gknd 12245 26 cases case NNS cord-010119-t1x9gknd 12245 27 . . . cord-010119-t1x9gknd 12246 1 Conclusion conclusion NN cord-010119-t1x9gknd 12246 2 : : : cord-010119-t1x9gknd 12247 1 The the DT cord-010119-t1x9gknd 12247 2 data datum NNS cord-010119-t1x9gknd 12247 3 analyzed analyze VBD cord-010119-t1x9gknd 12247 4 demonstrates demonstrate VBZ cord-010119-t1x9gknd 12247 5 that that IN cord-010119-t1x9gknd 12247 6 the the DT cord-010119-t1x9gknd 12247 7 majority majority NN cord-010119-t1x9gknd 12247 8 of of IN cord-010119-t1x9gknd 12247 9 surgeons surgeon NNS cord-010119-t1x9gknd 12247 10 are be VBP cord-010119-t1x9gknd 12247 11 adhering adhere VBG cord-010119-t1x9gknd 12247 12 to to IN cord-010119-t1x9gknd 12247 13 our -PRON- PRP$ cord-010119-t1x9gknd 12247 14 institutional institutional JJ cord-010119-t1x9gknd 12247 15 MSBOS MSBOS NNP cord-010119-t1x9gknd 12247 16 guidelines guideline NNS cord-010119-t1x9gknd 12247 17 . . . cord-010119-t1x9gknd 12248 1 It -PRON- PRP cord-010119-t1x9gknd 12248 2 was be VBD cord-010119-t1x9gknd 12248 3 noted note VBN cord-010119-t1x9gknd 12248 4 that that IN cord-010119-t1x9gknd 12248 5 surgeons surgeon NNS cord-010119-t1x9gknd 12248 6 are be VBP cord-010119-t1x9gknd 12248 7 requesting request VBG cord-010119-t1x9gknd 12248 8 products product NNS cord-010119-t1x9gknd 12248 9 be be VB cord-010119-t1x9gknd 12248 10 issued issue VBN cord-010119-t1x9gknd 12248 11 for for IN cord-010119-t1x9gknd 12248 12 invasive invasive JJ cord-010119-t1x9gknd 12248 13 procedures procedure NNS cord-010119-t1x9gknd 12248 14 where where WRB cord-010119-t1x9gknd 12248 15 rapid rapid JJ cord-010119-t1x9gknd 12248 16 exsanguination exsanguination NN cord-010119-t1x9gknd 12248 17 is be VBZ cord-010119-t1x9gknd 12248 18 possible possible JJ cord-010119-t1x9gknd 12248 19 . . . cord-010119-t1x9gknd 12249 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12249 2 analysis analysis NN cord-010119-t1x9gknd 12249 3 revealed reveal VBD cord-010119-t1x9gknd 12249 4 that that IN cord-010119-t1x9gknd 12249 5 the the DT cord-010119-t1x9gknd 12249 6 hospital hospital NN cord-010119-t1x9gknd 12249 7 's 's POS cord-010119-t1x9gknd 12249 8 MSBOS msbo NNS cord-010119-t1x9gknd 12249 9 does do VBZ cord-010119-t1x9gknd 12249 10 allow allow VB cord-010119-t1x9gknd 12249 11 for for IN cord-010119-t1x9gknd 12249 12 an an DT cord-010119-t1x9gknd 12249 13 excess excess NN cord-010119-t1x9gknd 12249 14 in in IN cord-010119-t1x9gknd 12249 15 blood blood NN cord-010119-t1x9gknd 12249 16 ordering ordering NN cord-010119-t1x9gknd 12249 17 for for IN cord-010119-t1x9gknd 12249 18 some some DT cord-010119-t1x9gknd 12249 19 surgical surgical JJ cord-010119-t1x9gknd 12249 20 procedures procedure NNS cord-010119-t1x9gknd 12249 21 . . . cord-010119-t1x9gknd 12250 1 The the DT cord-010119-t1x9gknd 12250 2 MSBOS MSBOS NNPS cord-010119-t1x9gknd 12250 3 should should MD cord-010119-t1x9gknd 12250 4 be be VB cord-010119-t1x9gknd 12250 5 updated update VBN cord-010119-t1x9gknd 12250 6 to to TO cord-010119-t1x9gknd 12250 7 reduce reduce VB cord-010119-t1x9gknd 12250 8 the the DT cord-010119-t1x9gknd 12250 9 suggested suggest VBN cord-010119-t1x9gknd 12250 10 maximum maximum JJ cord-010119-t1x9gknd 12250 11 product product NN cord-010119-t1x9gknd 12250 12 order order NN cord-010119-t1x9gknd 12250 13 . . . cord-010119-t1x9gknd 12251 1 In in IN cord-010119-t1x9gknd 12251 2 general general JJ cord-010119-t1x9gknd 12251 3 , , , cord-010119-t1x9gknd 12251 4 the the DT cord-010119-t1x9gknd 12251 5 data data NN cord-010119-t1x9gknd 12251 6 does do VBZ cord-010119-t1x9gknd 12251 7 not not RB cord-010119-t1x9gknd 12251 8 imply imply VB cord-010119-t1x9gknd 12251 9 that that IN cord-010119-t1x9gknd 12251 10 the the DT cord-010119-t1x9gknd 12251 11 blood blood NN cord-010119-t1x9gknd 12251 12 product product NN cord-010119-t1x9gknd 12251 13 wastage wastage NN cord-010119-t1x9gknd 12251 14 in in IN cord-010119-t1x9gknd 12251 15 the the DT cord-010119-t1x9gknd 12251 16 OR OR NNP cord-010119-t1x9gknd 12251 17 is be VBZ cord-010119-t1x9gknd 12251 18 due due JJ cord-010119-t1x9gknd 12251 19 to to IN cord-010119-t1x9gknd 12251 20 the the DT cord-010119-t1x9gknd 12251 21 ordering order VBG cord-010119-t1x9gknd 12251 22 practices practice NNS cord-010119-t1x9gknd 12251 23 of of IN cord-010119-t1x9gknd 12251 24 the the DT cord-010119-t1x9gknd 12251 25 surgeons surgeon NNS cord-010119-t1x9gknd 12251 26 . . . cord-010119-t1x9gknd 12252 1 A a DT cord-010119-t1x9gknd 12252 2 larger large JJR cord-010119-t1x9gknd 12252 3 period period NN cord-010119-t1x9gknd 12252 4 of of IN cord-010119-t1x9gknd 12252 5 surgical surgical JJ cord-010119-t1x9gknd 12252 6 blood blood NN cord-010119-t1x9gknd 12252 7 ordering ordering NN cord-010119-t1x9gknd 12252 8 practices practice NNS cord-010119-t1x9gknd 12252 9 should should MD cord-010119-t1x9gknd 12252 10 be be VB cord-010119-t1x9gknd 12252 11 analyzed analyze VBN cord-010119-t1x9gknd 12252 12 to to TO cord-010119-t1x9gknd 12252 13 detect detect VB cord-010119-t1x9gknd 12252 14 blood blood NN cord-010119-t1x9gknd 12252 15 product product NN cord-010119-t1x9gknd 12252 16 ordering ordering NN cord-010119-t1x9gknd 12252 17 , , , cord-010119-t1x9gknd 12252 18 utilization utilization NN cord-010119-t1x9gknd 12252 19 and and CC cord-010119-t1x9gknd 12252 20 wastage wastage NN cord-010119-t1x9gknd 12252 21 trends trend NNS cord-010119-t1x9gknd 12252 22 in in IN cord-010119-t1x9gknd 12252 23 other other JJ cord-010119-t1x9gknd 12252 24 subspecialties subspecialtie NNS cord-010119-t1x9gknd 12252 25 . . . cord-010119-t1x9gknd 12253 1 Background Background NNP cord-010119-t1x9gknd 12253 2 / / SYM cord-010119-t1x9gknd 12253 3 Case Case NNP cord-010119-t1x9gknd 12253 4 Studies Studies NNPS cord-010119-t1x9gknd 12253 5 : : : cord-010119-t1x9gknd 12254 1 The the DT cord-010119-t1x9gknd 12254 2 VisionV visionv NN cord-010119-t1x9gknd 12254 3 R r NN cord-010119-t1x9gknd 12254 4 and and CC cord-010119-t1x9gknd 12254 5 VisionV visionv NN cord-010119-t1x9gknd 12254 6 R r NN cord-010119-t1x9gknd 12254 7 Max Max NNP cord-010119-t1x9gknd 12254 8 ( ( -LRB- cord-010119-t1x9gknd 12254 9 Ortho Ortho NNP cord-010119-t1x9gknd 12254 10 Diagnostics Diagnostics NNP cord-010119-t1x9gknd 12254 11 , , , cord-010119-t1x9gknd 12254 12 Raritan Raritan NNP cord-010119-t1x9gknd 12254 13 New New NNP cord-010119-t1x9gknd 12254 14 Jersey Jersey NNP cord-010119-t1x9gknd 12254 15 ) ) -RRB- cord-010119-t1x9gknd 12254 16 are be VBP cord-010119-t1x9gknd 12254 17 ID ID NNP cord-010119-t1x9gknd 12254 18 - - HYPH cord-010119-t1x9gknd 12254 19 MTS MTS NNP cord-010119-t1x9gknd 12254 20 TM TM NNP cord-010119-t1x9gknd 12254 21 Gel Gel NNP cord-010119-t1x9gknd 12254 22 card card NN cord-010119-t1x9gknd 12254 23 - - HYPH cord-010119-t1x9gknd 12254 24 based base VBN cord-010119-t1x9gknd 12254 25 automated automate VBN cord-010119-t1x9gknd 12254 26 immunohematology immunohematology NN cord-010119-t1x9gknd 12254 27 analyzers analyzer NNS cord-010119-t1x9gknd 12254 28 marketed market VBN cord-010119-t1x9gknd 12254 29 for for IN cord-010119-t1x9gknd 12254 30 small small JJ cord-010119-t1x9gknd 12254 31 to to TO cord-010119-t1x9gknd 12254 32 medium medium NN cord-010119-t1x9gknd 12254 33 , , , cord-010119-t1x9gknd 12254 34 and and CC cord-010119-t1x9gknd 12254 35 high high JJ cord-010119-t1x9gknd 12254 36 - - HYPH cord-010119-t1x9gknd 12254 37 volume volume NN cord-010119-t1x9gknd 12254 38 [ [ -LRB- cord-010119-t1x9gknd 12254 39 > > SYM cord-010119-t1x9gknd 12254 40 50 50 CD cord-010119-t1x9gknd 12254 41 type type NN cord-010119-t1x9gknd 12254 42 and and CC cord-010119-t1x9gknd 12254 43 screens screen NNS cord-010119-t1x9gknd 12254 44 ( ( -LRB- cord-010119-t1x9gknd 12254 45 T&S t&s NN cord-010119-t1x9gknd 12254 46 ) ) -RRB- cord-010119-t1x9gknd 12254 47 per per IN cord-010119-t1x9gknd 12254 48 day day NN cord-010119-t1x9gknd 12254 49 ] ] -RRB- cord-010119-t1x9gknd 12254 50 blood blood NN cord-010119-t1x9gknd 12254 51 banks bank NNS cord-010119-t1x9gknd 12254 52 1 1 CD cord-010119-t1x9gknd 12254 53 , , , cord-010119-t1x9gknd 12254 54 respectively respectively RB cord-010119-t1x9gknd 12254 55 . . . cord-010119-t1x9gknd 12255 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12255 2 laboratory laboratory NN cord-010119-t1x9gknd 12255 3 which which WDT cord-010119-t1x9gknd 12255 4 serves serve VBZ cord-010119-t1x9gknd 12255 5 a a DT cord-010119-t1x9gknd 12255 6 large large JJ cord-010119-t1x9gknd 12255 7 1278-bed 1278-bed CD cord-010119-t1x9gknd 12255 8 multispecialty multispecialty JJ cord-010119-t1x9gknd 12255 9 academic academic JJ cord-010119-t1x9gknd 12255 10 hospital hospital NN cord-010119-t1x9gknd 12255 11 and and CC cord-010119-t1x9gknd 12255 12 receives receive VBZ cord-010119-t1x9gknd 12255 13 275 275 CD cord-010119-t1x9gknd 12255 14 - - SYM cord-010119-t1x9gknd 12255 15 300 300 CD cord-010119-t1x9gknd 12255 16 T&S t&s NN cord-010119-t1x9gknd 12255 17 specimens specimen NNS cord-010119-t1x9gknd 12255 18 per per IN cord-010119-t1x9gknd 12255 19 day day NN cord-010119-t1x9gknd 12255 20 needed need VBN cord-010119-t1x9gknd 12255 21 to to TO cord-010119-t1x9gknd 12255 22 replace replace VB cord-010119-t1x9gknd 12255 23 three three CD cord-010119-t1x9gknd 12255 24 ProVUE ProVUE NNP cord-010119-t1x9gknd 12255 25 analyzers analyzer NNS cord-010119-t1x9gknd 12255 26 prior prior RB cord-010119-t1x9gknd 12255 27 to to IN cord-010119-t1x9gknd 12255 28 the the DT cord-010119-t1x9gknd 12255 29 availability availability NN cord-010119-t1x9gknd 12255 30 of of IN cord-010119-t1x9gknd 12255 31 the the DT cord-010119-t1x9gknd 12255 32 VisionV visionv NN cord-010119-t1x9gknd 12255 33 R R NNP cord-010119-t1x9gknd 12255 34 Max Max NNP cord-010119-t1x9gknd 12255 35 . . . cord-010119-t1x9gknd 12256 1 We -PRON- PRP cord-010119-t1x9gknd 12256 2 implemented implement VBD cord-010119-t1x9gknd 12256 3 three three CD cord-010119-t1x9gknd 12256 4 VisionV visionv NN cord-010119-t1x9gknd 12256 5 R r NN cord-010119-t1x9gknd 12256 6 analyzers analyzer NNS cord-010119-t1x9gknd 12256 7 to to TO cord-010119-t1x9gknd 12256 8 work work VB cord-010119-t1x9gknd 12256 9 with with IN cord-010119-t1x9gknd 12256 10 our -PRON- PRP$ cord-010119-t1x9gknd 12256 11 existing exist VBG cord-010119-t1x9gknd 12256 12 NEOV NEOV NNP cord-010119-t1x9gknd 12256 13 R r NN cord-010119-t1x9gknd 12256 14 and and CC cord-010119-t1x9gknd 12256 15 ECHOV ECHOV NNP cord-010119-t1x9gknd 12256 16 R r NN cord-010119-t1x9gknd 12256 17 ( ( -LRB- cord-010119-t1x9gknd 12256 18 Immucor Immucor NNP cord-010119-t1x9gknd 12256 19 Inc Inc NNP cord-010119-t1x9gknd 12256 20 , , , cord-010119-t1x9gknd 12256 21 Norcross Norcross NNP cord-010119-t1x9gknd 12256 22 Georgia Georgia NNP cord-010119-t1x9gknd 12256 23 ) ) -RRB- cord-010119-t1x9gknd 12256 24 . . . cord-010119-t1x9gknd 12257 1 A a DT cord-010119-t1x9gknd 12257 2 recent recent JJ cord-010119-t1x9gknd 12257 3 multicenter multicenter JJ cord-010119-t1x9gknd 12257 4 field field NN cord-010119-t1x9gknd 12257 5 application application NN cord-010119-t1x9gknd 12257 6 trial trial NN cord-010119-t1x9gknd 12257 7 of of IN cord-010119-t1x9gknd 12257 8 the the DT cord-010119-t1x9gknd 12257 9 VisionV VisionV NNP cord-010119-t1x9gknd 12257 10 R R NNP cord-010119-t1x9gknd 12257 11 reported report VBD cord-010119-t1x9gknd 12257 12 a a DT cord-010119-t1x9gknd 12257 13 mean mean JJ cord-010119-t1x9gknd 12257 14 turnaround turnaround NN cord-010119-t1x9gknd 12257 15 time time NN cord-010119-t1x9gknd 12257 16 ( ( -LRB- cord-010119-t1x9gknd 12257 17 TAT tat NN cord-010119-t1x9gknd 12257 18 ) ) -RRB- cord-010119-t1x9gknd 12257 19 for for IN cord-010119-t1x9gknd 12257 20 T&S T&S NNP cord-010119-t1x9gknd 12257 21 and and CC cord-010119-t1x9gknd 12257 22 ABO ABO NNP cord-010119-t1x9gknd 12257 23 , , , cord-010119-t1x9gknd 12257 24 Rh Rh NNP cord-010119-t1x9gknd 12257 25 typing typing NN cord-010119-t1x9gknd 12257 26 ( ( -LRB- cord-010119-t1x9gknd 12257 27 ABO ABO NNP cord-010119-t1x9gknd 12257 28 / / SYM cord-010119-t1x9gknd 12257 29 Rh Rh NNP cord-010119-t1x9gknd 12257 30 ) ) -RRB- cord-010119-t1x9gknd 12257 31 of of IN cord-010119-t1x9gknd 12257 32 32.2 32.2 CD cord-010119-t1x9gknd 12257 33 6 6 CD cord-010119-t1x9gknd 12257 34 4.5 4.5 CD cord-010119-t1x9gknd 12257 35 and and CC cord-010119-t1x9gknd 12257 36 27.5 27.5 CD cord-010119-t1x9gknd 12257 37 6 6 CD cord-010119-t1x9gknd 12257 38 5.6 5.6 CD cord-010119-t1x9gknd 12257 39 minutes minute NNS cord-010119-t1x9gknd 12257 40 2 2 CD cord-010119-t1x9gknd 12257 41 , , , cord-010119-t1x9gknd 12257 42 respectively respectively RB cord-010119-t1x9gknd 12257 43 . . . cord-010119-t1x9gknd 12258 1 The the DT cord-010119-t1x9gknd 12258 2 objective objective NN cord-010119-t1x9gknd 12258 3 of of IN cord-010119-t1x9gknd 12258 4 this this DT cord-010119-t1x9gknd 12258 5 study study NN cord-010119-t1x9gknd 12258 6 was be VBD cord-010119-t1x9gknd 12258 7 to to TO cord-010119-t1x9gknd 12258 8 determine determine VB cord-010119-t1x9gknd 12258 9 VisionV visionv NN cord-010119-t1x9gknd 12258 10 R r NN cord-010119-t1x9gknd 12258 11 TATs tats NN cord-010119-t1x9gknd 12258 12 under under IN cord-010119-t1x9gknd 12258 13 routine routine JJ cord-010119-t1x9gknd 12258 14 daily daily JJ cord-010119-t1x9gknd 12258 15 high high JJ cord-010119-t1x9gknd 12258 16 - - HYPH cord-010119-t1x9gknd 12258 17 volume volume NN cord-010119-t1x9gknd 12258 18 practice practice NN cord-010119-t1x9gknd 12258 19 . . . cord-010119-t1x9gknd 12259 1 Study Study NNP cord-010119-t1x9gknd 12259 2 Design Design NNP cord-010119-t1x9gknd 12259 3 / / SYM cord-010119-t1x9gknd 12259 4 Methods method NNS cord-010119-t1x9gknd 12259 5 : : : cord-010119-t1x9gknd 12260 1 One one CD cord-010119-t1x9gknd 12260 2 VisionV visionv NN cord-010119-t1x9gknd 12260 3 R r NN cord-010119-t1x9gknd 12260 4 was be VBD cord-010119-t1x9gknd 12260 5 in in IN cord-010119-t1x9gknd 12260 6 operation operation NN cord-010119-t1x9gknd 12260 7 during during IN cord-010119-t1x9gknd 12260 8 a a DT cord-010119-t1x9gknd 12260 9 five five CD cord-010119-t1x9gknd 12260 10 - - HYPH cord-010119-t1x9gknd 12260 11 week week NN cord-010119-t1x9gknd 12260 12 period period NN cord-010119-t1x9gknd 12260 13 ( ( -LRB- cord-010119-t1x9gknd 12260 14 phase phase NN cord-010119-t1x9gknd 12260 15 I -PRON- PRP cord-010119-t1x9gknd 12260 16 ) ) -RRB- cord-010119-t1x9gknd 12260 17 , , , cord-010119-t1x9gknd 12260 18 and and CC cord-010119-t1x9gknd 12260 19 then then RB cord-010119-t1x9gknd 12260 20 two two CD cord-010119-t1x9gknd 12260 21 additional additional JJ cord-010119-t1x9gknd 12260 22 analyzers analyzer NNS cord-010119-t1x9gknd 12260 23 were be VBD cord-010119-t1x9gknd 12260 24 brought bring VBN cord-010119-t1x9gknd 12260 25 into into IN cord-010119-t1x9gknd 12260 26 service service NN cord-010119-t1x9gknd 12260 27 ( ( -LRB- cord-010119-t1x9gknd 12260 28 phase phase NN cord-010119-t1x9gknd 12260 29 II ii CD cord-010119-t1x9gknd 12260 30 ) ) -RRB- cord-010119-t1x9gknd 12260 31 . . . cord-010119-t1x9gknd 12261 1 TATs TATs NNP cord-010119-t1x9gknd 12261 2 are be VBP cord-010119-t1x9gknd 12261 3 defined define VBN cord-010119-t1x9gknd 12261 4 as as IN cord-010119-t1x9gknd 12261 5 the the DT cord-010119-t1x9gknd 12261 6 time time NN cord-010119-t1x9gknd 12261 7 when when WRB cord-010119-t1x9gknd 12261 8 the the DT cord-010119-t1x9gknd 12261 9 order order NN cord-010119-t1x9gknd 12261 10 is be VBZ cord-010119-t1x9gknd 12261 11 received receive VBN cord-010119-t1x9gknd 12261 12 by by IN cord-010119-t1x9gknd 12261 13 the the DT cord-010119-t1x9gknd 12261 14 instrument instrument NN cord-010119-t1x9gknd 12261 15 to to IN cord-010119-t1x9gknd 12261 16 when when WRB cord-010119-t1x9gknd 12261 17 the the DT cord-010119-t1x9gknd 12261 18 test test NN cord-010119-t1x9gknd 12261 19 is be VBZ cord-010119-t1x9gknd 12261 20 completed complete VBN cord-010119-t1x9gknd 12261 21 and and CC cord-010119-t1x9gknd 12261 22 available available JJ cord-010119-t1x9gknd 12261 23 for for IN cord-010119-t1x9gknd 12261 24 review review NN cord-010119-t1x9gknd 12261 25 . . . cord-010119-t1x9gknd 12262 1 Three three CD cord-010119-t1x9gknd 12262 2 - - HYPH cord-010119-t1x9gknd 12262 3 cell cell NN cord-010119-t1x9gknd 12262 4 screen screen NN cord-010119-t1x9gknd 12262 5 and and CC cord-010119-t1x9gknd 12262 6 ABO ABO NNP cord-010119-t1x9gknd 12262 7 / / SYM cord-010119-t1x9gknd 12262 8 Rh Rh NNP cord-010119-t1x9gknd 12262 9 TATs TATs NNP cord-010119-t1x9gknd 12262 10 , , , cord-010119-t1x9gknd 12262 11 and and CC cord-010119-t1x9gknd 12262 12 number number NN cord-010119-t1x9gknd 12262 13 of of IN cord-010119-t1x9gknd 12262 14 VisionV visionv NN cord-010119-t1x9gknd 12262 15 R r NN cord-010119-t1x9gknd 12262 16 antibody antibody NN cord-010119-t1x9gknd 12262 17 panels panel NNS cord-010119-t1x9gknd 12262 18 were be VBD cord-010119-t1x9gknd 12262 19 collected collect VBN cord-010119-t1x9gknd 12262 20 for for IN cord-010119-t1x9gknd 12262 21 a a DT cord-010119-t1x9gknd 12262 22 nine nine CD cord-010119-t1x9gknd 12262 23 - - HYPH cord-010119-t1x9gknd 12262 24 week week NN cord-010119-t1x9gknd 12262 25 period period NN cord-010119-t1x9gknd 12262 26 . . . cord-010119-t1x9gknd 12263 1 The the DT cord-010119-t1x9gknd 12263 2 TAT tat NN cord-010119-t1x9gknd 12263 3 for for IN cord-010119-t1x9gknd 12263 4 the the DT cord-010119-t1x9gknd 12263 5 screen screen NN cord-010119-t1x9gknd 12263 6 was be VBD cord-010119-t1x9gknd 12263 7 used use VBN cord-010119-t1x9gknd 12263 8 as as IN cord-010119-t1x9gknd 12263 9 the the DT cord-010119-t1x9gknd 12263 10 TAT tat NN cord-010119-t1x9gknd 12263 11 for for IN cord-010119-t1x9gknd 12263 12 the the DT cord-010119-t1x9gknd 12263 13 T&S T&S NNP cord-010119-t1x9gknd 12263 14 because because IN cord-010119-t1x9gknd 12263 15 the the DT cord-010119-t1x9gknd 12263 16 screen screen NN cord-010119-t1x9gknd 12263 17 is be VBZ cord-010119-t1x9gknd 12263 18 the the DT cord-010119-t1x9gknd 12263 19 rate rate NN cord-010119-t1x9gknd 12263 20 determining determine VBG cord-010119-t1x9gknd 12263 21 step step NN cord-010119-t1x9gknd 12263 22 . . . cord-010119-t1x9gknd 12264 1 All all DT cord-010119-t1x9gknd 12264 2 testing testing NN cord-010119-t1x9gknd 12264 3 was be VBD cord-010119-t1x9gknd 12264 4 performed perform VBN cord-010119-t1x9gknd 12264 5 using use VBG cord-010119-t1x9gknd 12264 6 in in IN cord-010119-t1x9gknd 12264 7 - - HYPH cord-010119-t1x9gknd 12264 8 service service NN cord-010119-t1x9gknd 12264 9 analyzers analyzer NNS cord-010119-t1x9gknd 12264 10 on on IN cord-010119-t1x9gknd 12264 11 routine routine JJ cord-010119-t1x9gknd 12264 12 patient patient NN cord-010119-t1x9gknd 12264 13 samples sample NNS cord-010119-t1x9gknd 12264 14 by by IN cord-010119-t1x9gknd 12264 15 trained train VBN cord-010119-t1x9gknd 12264 16 technologists technologist NNS cord-010119-t1x9gknd 12264 17 . . . cord-010119-t1x9gknd 12265 1 Samples sample NNS cord-010119-t1x9gknd 12265 2 were be VBD cord-010119-t1x9gknd 12265 3 not not RB cord-010119-t1x9gknd 12265 4 deliberately deliberately RB cord-010119-t1x9gknd 12265 5 batched batch VBN cord-010119-t1x9gknd 12265 6 but but CC cord-010119-t1x9gknd 12265 7 were be VBD cord-010119-t1x9gknd 12265 8 placed place VBN cord-010119-t1x9gknd 12265 9 on on IN cord-010119-t1x9gknd 12265 10 the the DT cord-010119-t1x9gknd 12265 11 analyzer analyzer NN cord-010119-t1x9gknd 12265 12 based base VBN cord-010119-t1x9gknd 12265 13 on on IN cord-010119-t1x9gknd 12265 14 the the DT cord-010119-t1x9gknd 12265 15 volume volume NN cord-010119-t1x9gknd 12265 16 and and CC cord-010119-t1x9gknd 12265 17 flow flow NN cord-010119-t1x9gknd 12265 18 of of IN cord-010119-t1x9gknd 12265 19 work work NN cord-010119-t1x9gknd 12265 20 at at IN cord-010119-t1x9gknd 12265 21 the the DT cord-010119-t1x9gknd 12265 22 time time NN cord-010119-t1x9gknd 12265 23 . . . cord-010119-t1x9gknd 12266 1 Results result NNS cord-010119-t1x9gknd 12266 2 / / SYM cord-010119-t1x9gknd 12266 3 Findings finding NNS cord-010119-t1x9gknd 12266 4 : : : cord-010119-t1x9gknd 12267 1 Under under IN cord-010119-t1x9gknd 12267 2 the the DT cord-010119-t1x9gknd 12267 3 high high JJ cord-010119-t1x9gknd 12267 4 volume volume NN cord-010119-t1x9gknd 12267 5 conditions condition NNS cord-010119-t1x9gknd 12267 6 of of IN cord-010119-t1x9gknd 12267 7 our -PRON- PRP$ cord-010119-t1x9gknd 12267 8 laboratory laboratory NN cord-010119-t1x9gknd 12267 9 with with IN cord-010119-t1x9gknd 12267 10 three three CD cord-010119-t1x9gknd 12267 11 VisionV visionv NN cord-010119-t1x9gknd 12267 12 R r NN cord-010119-t1x9gknd 12267 13 analyzers analyzer NNS cord-010119-t1x9gknd 12267 14 , , , cord-010119-t1x9gknd 12267 15 the the DT cord-010119-t1x9gknd 12267 16 mean mean JJ cord-010119-t1x9gknd 12267 17 T&S T&S NNP cord-010119-t1x9gknd 12267 18 TAT TAT NNP cord-010119-t1x9gknd 12267 19 was be VBD cord-010119-t1x9gknd 12267 20 30 30 CD cord-010119-t1x9gknd 12267 21 % % NN cord-010119-t1x9gknd 12267 22 longer long RBR cord-010119-t1x9gknd 12267 23 and and CC cord-010119-t1x9gknd 12267 24 had have VBD cord-010119-t1x9gknd 12267 25 a a DT cord-010119-t1x9gknd 12267 26 larger large JJR cord-010119-t1x9gknd 12267 27 standard standard JJ cord-010119-t1x9gknd 12267 28 deviation deviation NN cord-010119-t1x9gknd 12267 29 ( ( -LRB- cord-010119-t1x9gknd 12267 30 S.D. S.D. NNP cord-010119-t1x9gknd 12267 31 ) ) -RRB- cord-010119-t1x9gknd 12267 32 than than IN cord-010119-t1x9gknd 12267 33 the the DT cord-010119-t1x9gknd 12267 34 published publish VBN cord-010119-t1x9gknd 12267 35 trial trial NN cord-010119-t1x9gknd 12267 36 result result NN cord-010119-t1x9gknd 12267 37 of of IN cord-010119-t1x9gknd 12267 38 32.2 32.2 CD cord-010119-t1x9gknd 12267 39 6 6 CD cord-010119-t1x9gknd 12267 40 4.5 4.5 CD cord-010119-t1x9gknd 12267 41 . . . cord-010119-t1x9gknd 12268 1 TRANSFUSION TRANSFUSION NNP cord-010119-t1x9gknd 12268 2 2017 2017 CD cord-010119-t1x9gknd 12268 3 Vol Vol NNP cord-010119-t1x9gknd 12268 4 . . . cord-010119-t1x9gknd 12269 1 57 57 CD cord-010119-t1x9gknd 12270 1 Supplement supplement NN cord-010119-t1x9gknd 12270 2 S3 S3 NNP cord-010119-t1x9gknd 12270 3 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 12271 1 During during IN cord-010119-t1x9gknd 12271 2 phase phase NN cord-010119-t1x9gknd 12271 3 I -PRON- PRP cord-010119-t1x9gknd 12271 4 VisionV visionv VBP cord-010119-t1x9gknd 12271 5 R r NN cord-010119-t1x9gknd 12271 6 1 1 CD cord-010119-t1x9gknd 12271 7 performed perform VBD cord-010119-t1x9gknd 12271 8 263 263 CD cord-010119-t1x9gknd 12271 9 panels panel NNS cord-010119-t1x9gknd 12271 10 . . . cord-010119-t1x9gknd 12272 1 During during IN cord-010119-t1x9gknd 12272 2 phase phase NN cord-010119-t1x9gknd 12272 3 II II NNP cord-010119-t1x9gknd 12272 4 VisionV visionv NN cord-010119-t1x9gknd 12272 5 R r NN cord-010119-t1x9gknd 12272 6 1 1 CD cord-010119-t1x9gknd 12272 7 performed perform VBD cord-010119-t1x9gknd 12272 8 351 351 CD cord-010119-t1x9gknd 12272 9 of of IN cord-010119-t1x9gknd 12272 10 the the DT cord-010119-t1x9gknd 12272 11 361 361 CD cord-010119-t1x9gknd 12272 12 VisionV visionv NN cord-010119-t1x9gknd 12272 13 R r NN cord-010119-t1x9gknd 12272 14 panels panel NNS cord-010119-t1x9gknd 12272 15 . . . cord-010119-t1x9gknd 12273 1 Conclusion conclusion NN cord-010119-t1x9gknd 12273 2 : : : cord-010119-t1x9gknd 12274 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12274 2 VisionV visionv NN cord-010119-t1x9gknd 12274 3 R r NN cord-010119-t1x9gknd 12274 4 analyzers analyzer NNS cord-010119-t1x9gknd 12274 5 are be VBP cord-010119-t1x9gknd 12274 6 used use VBN cord-010119-t1x9gknd 12274 7 under under IN cord-010119-t1x9gknd 12274 8 high high JJ cord-010119-t1x9gknd 12274 9 volume volume NN cord-010119-t1x9gknd 12274 10 conditions condition NNS cord-010119-t1x9gknd 12274 11 more more RBR cord-010119-t1x9gknd 12274 12 suitable suitable JJ cord-010119-t1x9gknd 12274 13 for for IN cord-010119-t1x9gknd 12274 14 the the DT cord-010119-t1x9gknd 12274 15 VisionV visionv NN cord-010119-t1x9gknd 12274 16 R R NNP cord-010119-t1x9gknd 12274 17 Max Max NNP cord-010119-t1x9gknd 12274 18 . . . cord-010119-t1x9gknd 12275 1 When when WRB cord-010119-t1x9gknd 12275 2 balanced balance VBN cord-010119-t1x9gknd 12275 3 with with IN cord-010119-t1x9gknd 12275 4 the the DT cord-010119-t1x9gknd 12275 5 testing testing NN cord-010119-t1x9gknd 12275 6 menu menu NN cord-010119-t1x9gknd 12275 7 , , , cord-010119-t1x9gknd 12275 8 including include VBG cord-010119-t1x9gknd 12275 9 ability ability NN cord-010119-t1x9gknd 12275 10 to to TO cord-010119-t1x9gknd 12275 11 perform perform VB cord-010119-t1x9gknd 12275 12 select select JJ cord-010119-t1x9gknd 12275 13 cell cell NN cord-010119-t1x9gknd 12275 14 panels panel NNS cord-010119-t1x9gknd 12275 15 , , , cord-010119-t1x9gknd 12275 16 our -PRON- PRP$ cord-010119-t1x9gknd 12275 17 TATs tat NNS cord-010119-t1x9gknd 12275 18 using use VBG cord-010119-t1x9gknd 12275 19 three three CD cord-010119-t1x9gknd 12275 20 analyzers analyzer NNS cord-010119-t1x9gknd 12275 21 were be VBD cord-010119-t1x9gknd 12275 22 satisfactory satisfactory JJ cord-010119-t1x9gknd 12275 23 . . . cord-010119-t1x9gknd 12276 1 The the DT cord-010119-t1x9gknd 12276 2 large large JJ cord-010119-t1x9gknd 12276 3 standard standard JJ cord-010119-t1x9gknd 12276 4 deviation deviation NN cord-010119-t1x9gknd 12276 5 indicates indicate VBZ cord-010119-t1x9gknd 12276 6 that that IN cord-010119-t1x9gknd 12276 7 opportunities opportunity NNS cord-010119-t1x9gknd 12276 8 remain remain VBP cord-010119-t1x9gknd 12276 9 for for IN cord-010119-t1x9gknd 12276 10 improving improve VBG cord-010119-t1x9gknd 12276 11 TATs TATs NNP cord-010119-t1x9gknd 12276 12 through through IN cord-010119-t1x9gknd 12276 13 workflow workflow NN cord-010119-t1x9gknd 12276 14 improvement improvement NN cord-010119-t1x9gknd 12276 15 . . . cord-010119-t1x9gknd 12276 16 _SP cord-010119-t1x9gknd 12277 1 From from IN cord-010119-t1x9gknd 12277 2 West West NNP cord-010119-t1x9gknd 12277 3 Nile Nile NNP cord-010119-t1x9gknd 12277 4 Virus Virus NNP cord-010119-t1x9gknd 12277 5 to to IN cord-010119-t1x9gknd 12277 6 the the DT cord-010119-t1x9gknd 12277 7 Emergence Emergence NNP cord-010119-t1x9gknd 12277 8 of of IN cord-010119-t1x9gknd 12277 9 Zika Zika NNP cord-010119-t1x9gknd 12277 10 Virus Virus NNP cord-010119-t1x9gknd 12277 11 : : : cord-010119-t1x9gknd 12278 1 A a DT cord-010119-t1x9gknd 12278 2 Nationwide Nationwide NNP cord-010119-t1x9gknd 12278 3 Survey Survey NNP cord-010119-t1x9gknd 12278 4 of of IN cord-010119-t1x9gknd 12278 5 How how WRB cord-010119-t1x9gknd 12278 6 Regulators regulator NNS cord-010119-t1x9gknd 12278 7 Are be VBP cord-010119-t1x9gknd 12278 8 Keeping keep VBG cord-010119-t1x9gknd 12278 9 the the DT cord-010119-t1x9gknd 12278 10 Blood Blood NNP cord-010119-t1x9gknd 12278 11 Supply Supply NNP cord-010119-t1x9gknd 12279 1 Safe safe JJ cord-010119-t1x9gknd 12279 2 and and CC cord-010119-t1x9gknd 12279 3 Available available JJ cord-010119-t1x9gknd 12279 4 Falisha Falisha NNP cord-010119-t1x9gknd 12279 5 Atwell Atwell NNP cord-010119-t1x9gknd 12279 6 * * NFP cord-010119-t1x9gknd 12279 7 1 1 CD cord-010119-t1x9gknd 12279 8 , , , cord-010119-t1x9gknd 12279 9 John John NNP cord-010119-t1x9gknd 12279 10 Roback Roback NNP cord-010119-t1x9gknd 12279 11 2 2 CD cord-010119-t1x9gknd 12279 12 , , , cord-010119-t1x9gknd 12279 13 Ronald Ronald NNP cord-010119-t1x9gknd 12279 14 Arkin Arkin NNP cord-010119-t1x9gknd 12279 15 1 1 CD cord-010119-t1x9gknd 12279 16 , , , cord-010119-t1x9gknd 12279 17 Michael Michael NNP cord-010119-t1x9gknd 12279 18 Bartlett Bartlett NNP cord-010119-t1x9gknd 12279 19 1 1 CD cord-010119-t1x9gknd 12279 20 , , , cord-010119-t1x9gknd 12279 21 Robert Robert NNP cord-010119-t1x9gknd 12279 22 Geiger Geiger NNP cord-010119-t1x9gknd 12279 23 1 1 CD cord-010119-t1x9gknd 12279 24 and and CC cord-010119-t1x9gknd 12279 25 Jaxk Jaxk NNP cord-010119-t1x9gknd 12279 26 Reeves Reeves NNP cord-010119-t1x9gknd 12279 27 1 1 CD cord-010119-t1x9gknd 12279 28 . . . cord-010119-t1x9gknd 12280 1 1 1 CD cord-010119-t1x9gknd 12280 2 University University NNP cord-010119-t1x9gknd 12280 3 of of IN cord-010119-t1x9gknd 12280 4 Georgia Georgia NNP cord-010119-t1x9gknd 12280 5 , , , cord-010119-t1x9gknd 12280 6 2 2 CD cord-010119-t1x9gknd 12280 7 Emory Emory NNP cord-010119-t1x9gknd 12280 8 Hospital Hospital NNP cord-010119-t1x9gknd 12280 9 Background Background NNP cord-010119-t1x9gknd 12280 10 / / SYM cord-010119-t1x9gknd 12280 11 Case Case NNP cord-010119-t1x9gknd 12280 12 Studies Studies NNPS cord-010119-t1x9gknd 12280 13 : : : cord-010119-t1x9gknd 12281 1 With with IN cord-010119-t1x9gknd 12281 2 the the DT cord-010119-t1x9gknd 12281 3 emergence emergence NN cord-010119-t1x9gknd 12281 4 of of IN cord-010119-t1x9gknd 12281 5 ZIKV ZIKV NNP cord-010119-t1x9gknd 12281 6 in in IN cord-010119-t1x9gknd 12281 7 the the DT cord-010119-t1x9gknd 12281 8 United United NNP cord-010119-t1x9gknd 12281 9 States States NNP cord-010119-t1x9gknd 12281 10 , , , cord-010119-t1x9gknd 12281 11 it -PRON- PRP cord-010119-t1x9gknd 12281 12 is be VBZ cord-010119-t1x9gknd 12281 13 important important JJ cord-010119-t1x9gknd 12281 14 to to TO cord-010119-t1x9gknd 12281 15 assess assess VB cord-010119-t1x9gknd 12281 16 the the DT cord-010119-t1x9gknd 12281 17 FDA FDA NNP cord-010119-t1x9gknd 12281 18 's 's POS cord-010119-t1x9gknd 12281 19 response response NN cord-010119-t1x9gknd 12281 20 time time NN cord-010119-t1x9gknd 12281 21 in in IN cord-010119-t1x9gknd 12281 22 providing provide VBG cord-010119-t1x9gknd 12281 23 guidance guidance NN cord-010119-t1x9gknd 12281 24 to to TO cord-010119-t1x9gknd 12281 25 ensure ensure VB cord-010119-t1x9gknd 12281 26 the the DT cord-010119-t1x9gknd 12281 27 safety safety NN cord-010119-t1x9gknd 12281 28 and and CC cord-010119-t1x9gknd 12281 29 availability availability NN cord-010119-t1x9gknd 12281 30 of of IN cord-010119-t1x9gknd 12281 31 blood blood NN cord-010119-t1x9gknd 12281 32 products product NNS cord-010119-t1x9gknd 12281 33 in in IN cord-010119-t1x9gknd 12281 34 the the DT cord-010119-t1x9gknd 12281 35 face face NN cord-010119-t1x9gknd 12281 36 of of IN cord-010119-t1x9gknd 12281 37 newly newly RB cord-010119-t1x9gknd 12281 38 emerging emerge VBG cord-010119-t1x9gknd 12281 39 infectious infectious JJ cord-010119-t1x9gknd 12281 40 diseases disease NNS cord-010119-t1x9gknd 12281 41 . . . cord-010119-t1x9gknd 12282 1 This this DT cord-010119-t1x9gknd 12282 2 research research NN cord-010119-t1x9gknd 12282 3 compares compare VBZ cord-010119-t1x9gknd 12282 4 the the DT cord-010119-t1x9gknd 12282 5 responsiveness responsiveness NN cord-010119-t1x9gknd 12282 6 of of IN cord-010119-t1x9gknd 12282 7 the the DT cord-010119-t1x9gknd 12282 8 FDA FDA NNP cord-010119-t1x9gknd 12282 9 during during IN cord-010119-t1x9gknd 12282 10 West West NNP cord-010119-t1x9gknd 12282 11 Nile Nile NNP cord-010119-t1x9gknd 12282 12 Virus Virus NNP cord-010119-t1x9gknd 12282 13 ( ( -LRB- cord-010119-t1x9gknd 12282 14 WNV WNV NNP cord-010119-t1x9gknd 12282 15 ) ) -RRB- cord-010119-t1x9gknd 12282 16 and and CC cord-010119-t1x9gknd 12282 17 Zika Zika NNP cord-010119-t1x9gknd 12282 18 Virus Virus NNP cord-010119-t1x9gknd 12282 19 ( ( -LRB- cord-010119-t1x9gknd 12282 20 ZIKV ZIKV NNP cord-010119-t1x9gknd 12282 21 ) ) -RRB- cord-010119-t1x9gknd 12282 22 outbreaks outbreak NNS cord-010119-t1x9gknd 12282 23 to to TO cord-010119-t1x9gknd 12282 24 evaluate evaluate VB cord-010119-t1x9gknd 12282 25 our -PRON- PRP$ cord-010119-t1x9gknd 12282 26 current current JJ cord-010119-t1x9gknd 12282 27 preparedness preparedness NN cord-010119-t1x9gknd 12282 28 . . . cord-010119-t1x9gknd 12283 1 Study Study NNP cord-010119-t1x9gknd 12283 2 Design Design NNP cord-010119-t1x9gknd 12283 3 / / SYM cord-010119-t1x9gknd 12283 4 Methods method NNS cord-010119-t1x9gknd 12283 5 : : : cord-010119-t1x9gknd 12283 6 The the DT cord-010119-t1x9gknd 12283 7 literature literature NN cord-010119-t1x9gknd 12283 8 review review NN cord-010119-t1x9gknd 12283 9 was be VBD cord-010119-t1x9gknd 12283 10 conducted conduct VBN cord-010119-t1x9gknd 12283 11 to to TO cord-010119-t1x9gknd 12283 12 analyze analyze VB cord-010119-t1x9gknd 12283 13 FDA FDA NNP cord-010119-t1x9gknd 12283 14 's 's POS cord-010119-t1x9gknd 12283 15 response response NN cord-010119-t1x9gknd 12283 16 time time NN cord-010119-t1x9gknd 12283 17 during during IN cord-010119-t1x9gknd 12283 18 the the DT cord-010119-t1x9gknd 12283 19 WNV WNV NNP cord-010119-t1x9gknd 12283 20 crisis crisis NN cord-010119-t1x9gknd 12283 21 and and CC cord-010119-t1x9gknd 12283 22 determine determine VB cord-010119-t1x9gknd 12283 23 if if IN cord-010119-t1x9gknd 12283 24 it -PRON- PRP cord-010119-t1x9gknd 12283 25 was be VBD cord-010119-t1x9gknd 12283 26 effective effective JJ cord-010119-t1x9gknd 12283 27 and and CC cord-010119-t1x9gknd 12283 28 efficient efficient JJ cord-010119-t1x9gknd 12283 29 . . . cord-010119-t1x9gknd 12284 1 The the DT cord-010119-t1x9gknd 12284 2 research research NN cord-010119-t1x9gknd 12284 3 survey survey NN cord-010119-t1x9gknd 12284 4 was be VBD cord-010119-t1x9gknd 12284 5 performed perform VBN cord-010119-t1x9gknd 12284 6 to to TO cord-010119-t1x9gknd 12284 7 determine determine VB cord-010119-t1x9gknd 12284 8 if if IN cord-010119-t1x9gknd 12284 9 the the DT cord-010119-t1x9gknd 12284 10 Donor Donor NNP cord-010119-t1x9gknd 12284 11 History History NNP cord-010119-t1x9gknd 12284 12 Questionnaire Questionnaire NNP cord-010119-t1x9gknd 12284 13 ( ( -LRB- cord-010119-t1x9gknd 12284 14 DHQ DHQ NNP cord-010119-t1x9gknd 12284 15 ) ) -RRB- cord-010119-t1x9gknd 12284 16 adequately adequately RB cord-010119-t1x9gknd 12284 17 screens screen VBZ cord-010119-t1x9gknd 12284 18 donors donor NNS cord-010119-t1x9gknd 12284 19 for for IN cord-010119-t1x9gknd 12284 20 ZIKV ZIKV NNP cord-010119-t1x9gknd 12284 21 as as IN cord-010119-t1x9gknd 12284 22 the the DT cord-010119-t1x9gknd 12284 23 sole sole JJ cord-010119-t1x9gknd 12284 24 preventive preventive JJ cord-010119-t1x9gknd 12284 25 method method NN cord-010119-t1x9gknd 12284 26 ( ( -LRB- cord-010119-t1x9gknd 12284 27 as as IN cord-010119-t1x9gknd 12284 28 per per IN cord-010119-t1x9gknd 12284 29 the the DT cord-010119-t1x9gknd 12284 30 February February NNP cord-010119-t1x9gknd 12284 31 2016 2016 CD cord-010119-t1x9gknd 12284 32 Guidance Guidance NNP cord-010119-t1x9gknd 12284 33 for for IN cord-010119-t1x9gknd 12284 34 Industry industry NN cord-010119-t1x9gknd 12284 35 : : : cord-010119-t1x9gknd 12284 36 Recommendations recommendation NNS cord-010119-t1x9gknd 12284 37 for for IN cord-010119-t1x9gknd 12284 38 Donor Donor NNP cord-010119-t1x9gknd 12284 39 Screening screening NN cord-010119-t1x9gknd 12284 40 , , , cord-010119-t1x9gknd 12284 41 Deferral deferral NN cord-010119-t1x9gknd 12284 42 and and CC cord-010119-t1x9gknd 12284 43 Product Product NNP cord-010119-t1x9gknd 12284 44 Management Management NNP cord-010119-t1x9gknd 12284 45 to to TO cord-010119-t1x9gknd 12284 46 Reduce reduce VB cord-010119-t1x9gknd 12284 47 the the DT cord-010119-t1x9gknd 12284 48 Risk Risk NNP cord-010119-t1x9gknd 12284 49 of of IN cord-010119-t1x9gknd 12284 50 Transfusion Transfusion NNP cord-010119-t1x9gknd 12284 51 - - HYPH cord-010119-t1x9gknd 12284 52 Transmission Transmission NNP cord-010119-t1x9gknd 12284 53 of of IN cord-010119-t1x9gknd 12284 54 Zika Zika NNP cord-010119-t1x9gknd 12284 55 Virus Virus NNP cord-010119-t1x9gknd 12284 56 ) ) -RRB- cord-010119-t1x9gknd 12284 57 and and CC cord-010119-t1x9gknd 12284 58 to to TO cord-010119-t1x9gknd 12284 59 determine determine VB cord-010119-t1x9gknd 12284 60 if if IN cord-010119-t1x9gknd 12284 61 the the DT cord-010119-t1x9gknd 12284 62 current current JJ cord-010119-t1x9gknd 12284 63 regulatory regulatory JJ cord-010119-t1x9gknd 12284 64 practices practice NNS cord-010119-t1x9gknd 12284 65 ( ( -LRB- cord-010119-t1x9gknd 12284 66 including include VBG cord-010119-t1x9gknd 12284 67 the the DT cord-010119-t1x9gknd 12284 68 August August NNP cord-010119-t1x9gknd 12284 69 2016 2016 CD cord-010119-t1x9gknd 12284 70 Guidance Guidance NNP cord-010119-t1x9gknd 12284 71 for for IN cord-010119-t1x9gknd 12284 72 Industry industry NN cord-010119-t1x9gknd 12284 73 : : : cord-010119-t1x9gknd 12284 74 Revised Revised NNP cord-010119-t1x9gknd 12284 75 Recommendations Recommendations NNPS cord-010119-t1x9gknd 12284 76 for for IN cord-010119-t1x9gknd 12284 77 Reducing reduce VBG cord-010119-t1x9gknd 12284 78 the the DT cord-010119-t1x9gknd 12284 79 Risk Risk NNP cord-010119-t1x9gknd 12284 80 of of IN cord-010119-t1x9gknd 12284 81 Zika Zika NNP cord-010119-t1x9gknd 12284 82 Virus Virus NNP cord-010119-t1x9gknd 12284 83 Transmission Transmission NNP cord-010119-t1x9gknd 12284 84 by by IN cord-010119-t1x9gknd 12284 85 Blood blood NN cord-010119-t1x9gknd 12284 86 and and CC cord-010119-t1x9gknd 12284 87 Blood blood NN cord-010119-t1x9gknd 12284 88 Components component NNS cord-010119-t1x9gknd 12284 89 ) ) -RRB- cord-010119-t1x9gknd 12284 90 are be VBP cord-010119-t1x9gknd 12284 91 perceived perceive VBN cord-010119-t1x9gknd 12284 92 to to TO cord-010119-t1x9gknd 12284 93 be be VB cord-010119-t1x9gknd 12284 94 effective effective JJ cord-010119-t1x9gknd 12284 95 and and CC cord-010119-t1x9gknd 12284 96 efficient efficient JJ cord-010119-t1x9gknd 12284 97 in in IN cord-010119-t1x9gknd 12284 98 the the DT cord-010119-t1x9gknd 12284 99 face face NN cord-010119-t1x9gknd 12284 100 of of IN cord-010119-t1x9gknd 12284 101 the the DT cord-010119-t1x9gknd 12284 102 current current JJ cord-010119-t1x9gknd 12284 103 ZIKV ZIKV NNP cord-010119-t1x9gknd 12284 104 outbreak outbreak NN cord-010119-t1x9gknd 12284 105 . . . cord-010119-t1x9gknd 12285 1 Survey Survey NNP cord-010119-t1x9gknd 12285 2 Monkey Monkey NNP cord-010119-t1x9gknd 12285 3 was be VBD cord-010119-t1x9gknd 12285 4 used use VBN cord-010119-t1x9gknd 12285 5 and and CC cord-010119-t1x9gknd 12285 6 participation participation NN cord-010119-t1x9gknd 12285 7 was be VBD cord-010119-t1x9gknd 12285 8 anonymous anonymous JJ cord-010119-t1x9gknd 12285 9 . . . cord-010119-t1x9gknd 12286 1 Over over IN cord-010119-t1x9gknd 12286 2 4,000 4,000 CD cord-010119-t1x9gknd 12286 3 emails email NNS cord-010119-t1x9gknd 12286 4 and and CC cord-010119-t1x9gknd 12286 5 web web NN cord-010119-t1x9gknd 12286 6 - - HYPH cord-010119-t1x9gknd 12286 7 links link NNS cord-010119-t1x9gknd 12286 8 were be VBD cord-010119-t1x9gknd 12286 9 sent send VBN cord-010119-t1x9gknd 12286 10 to to IN cord-010119-t1x9gknd 12286 11 members member NNS cord-010119-t1x9gknd 12286 12 of of IN cord-010119-t1x9gknd 12286 13 AABB AABB NNP cord-010119-t1x9gknd 12286 14 , , , cord-010119-t1x9gknd 12286 15 SCABB SCABB NNP cord-010119-t1x9gknd 12286 16 , , , cord-010119-t1x9gknd 12286 17 SEABB SEABB NNS cord-010119-t1x9gknd 12286 18 , , , cord-010119-t1x9gknd 12286 19 and and CC cord-010119-t1x9gknd 12286 20 personal personal JJ cord-010119-t1x9gknd 12286 21 network network NN cord-010119-t1x9gknd 12286 22 with with IN cord-010119-t1x9gknd 12286 23 a a DT cord-010119-t1x9gknd 12286 24 10 10 CD cord-010119-t1x9gknd 12286 25 % % NN cord-010119-t1x9gknd 12286 26 target target NN cord-010119-t1x9gknd 12286 27 response response NN cord-010119-t1x9gknd 12286 28 rate rate NN cord-010119-t1x9gknd 12286 29 . . . cord-010119-t1x9gknd 12287 1 Participants participant NNS cord-010119-t1x9gknd 12287 2 self self NN cord-010119-t1x9gknd 12287 3 - - HYPH cord-010119-t1x9gknd 12287 4 selected select VBN cord-010119-t1x9gknd 12287 5 or or CC cord-010119-t1x9gknd 12287 6 deselected deselecte VBN cord-010119-t1x9gknd 12287 7 based base VBN cord-010119-t1x9gknd 12287 8 on on IN cord-010119-t1x9gknd 12287 9 the the DT cord-010119-t1x9gknd 12287 10 inclusion inclusion NN cord-010119-t1x9gknd 12287 11 and and CC cord-010119-t1x9gknd 12287 12 exclusion exclusion NN cord-010119-t1x9gknd 12287 13 criteria criterion NNS cord-010119-t1x9gknd 12287 14 listed list VBN cord-010119-t1x9gknd 12287 15 in in IN cord-010119-t1x9gknd 12287 16 the the DT cord-010119-t1x9gknd 12287 17 consent consent NN cord-010119-t1x9gknd 12287 18 letter letter NN cord-010119-t1x9gknd 12287 19 . . . cord-010119-t1x9gknd 12288 1 Results result NNS cord-010119-t1x9gknd 12288 2 / / SYM cord-010119-t1x9gknd 12288 3 Findings finding NNS cord-010119-t1x9gknd 12288 4 : : : cord-010119-t1x9gknd 12289 1 The the DT cord-010119-t1x9gknd 12289 2 literature literature NN cord-010119-t1x9gknd 12289 3 review review NN cord-010119-t1x9gknd 12289 4 revealed reveal VBD cord-010119-t1x9gknd 12289 5 that that IN cord-010119-t1x9gknd 12289 6 the the DT cord-010119-t1x9gknd 12289 7 FDA FDA NNP cord-010119-t1x9gknd 12289 8 's 's POS cord-010119-t1x9gknd 12289 9 response response NN cord-010119-t1x9gknd 12289 10 was be VBD cord-010119-t1x9gknd 12289 11 slow slow JJ cord-010119-t1x9gknd 12289 12 during during IN cord-010119-t1x9gknd 12289 13 the the DT cord-010119-t1x9gknd 12289 14 WNV WNV NNP cord-010119-t1x9gknd 12289 15 outbreak outbreak NN cord-010119-t1x9gknd 12289 16 , , , cord-010119-t1x9gknd 12289 17 while while IN cord-010119-t1x9gknd 12289 18 the the DT cord-010119-t1x9gknd 12289 19 ZIKV ZIKV NNP cord-010119-t1x9gknd 12289 20 response response NN cord-010119-t1x9gknd 12289 21 is be VBZ cord-010119-t1x9gknd 12289 22 efficient efficient JJ cord-010119-t1x9gknd 12289 23 thus thus RB cord-010119-t1x9gknd 12289 24 far far RB cord-010119-t1x9gknd 12289 25 . . . cord-010119-t1x9gknd 12290 1 A a DT cord-010119-t1x9gknd 12290 2 total total NN cord-010119-t1x9gknd 12290 3 of of IN cord-010119-t1x9gknd 12290 4 317 317 CD cord-010119-t1x9gknd 12290 5 participants participant NNS cord-010119-t1x9gknd 12290 6 responded respond VBD cord-010119-t1x9gknd 12290 7 to to IN cord-010119-t1x9gknd 12290 8 the the DT cord-010119-t1x9gknd 12290 9 survey survey NN cord-010119-t1x9gknd 12290 10 ( ( -LRB- cord-010119-t1x9gknd 12290 11 7.94 7.94 CD cord-010119-t1x9gknd 12290 12 % % NN cord-010119-t1x9gknd 12290 13 response response NN cord-010119-t1x9gknd 12290 14 rate rate NN cord-010119-t1x9gknd 12290 15 ) ) -RRB- cord-010119-t1x9gknd 12290 16 . . . cord-010119-t1x9gknd 12291 1 Statistically statistically RB cord-010119-t1x9gknd 12291 2 , , , cord-010119-t1x9gknd 12291 3 participant participant NN cord-010119-t1x9gknd 12291 4 agreement agreement NN cord-010119-t1x9gknd 12291 5 with with IN cord-010119-t1x9gknd 12291 6 FDA FDA NNP cord-010119-t1x9gknd 12291 7 's 's POS cord-010119-t1x9gknd 12291 8 decisions decision NNS cord-010119-t1x9gknd 12291 9 was be VBD cord-010119-t1x9gknd 12291 10 performed perform VBN cord-010119-t1x9gknd 12291 11 by by IN cord-010119-t1x9gknd 12291 12 " " `` cord-010119-t1x9gknd 12291 13 t t NNP cord-010119-t1x9gknd 12291 14 " " '' cord-010119-t1x9gknd 12291 15 test test NN cord-010119-t1x9gknd 12291 16 ( ( -LRB- cord-010119-t1x9gknd 12291 17 with with IN cord-010119-t1x9gknd 12291 18 n-15317 n-15317 NNP cord-010119-t1x9gknd 12291 19 - - HYPH cord-010119-t1x9gknd 12291 20 15316 15316 CD cord-010119-t1x9gknd 12291 21 df df NNP cord-010119-t1x9gknd 12291 22 ) ) -RRB- cord-010119-t1x9gknd 12291 23 of of IN cord-010119-t1x9gknd 12291 24 the the DT cord-010119-t1x9gknd 12291 25 null null JJ cord-010119-t1x9gknd 12291 26 hypothesis hypothesis NN cord-010119-t1x9gknd 12291 27 that that IN cord-010119-t1x9gknd 12291 28 the the DT cord-010119-t1x9gknd 12291 29 mean50 mean50 NNP cord-010119-t1x9gknd 12291 30 vs. vs. IN cord-010119-t1x9gknd 12291 31 the the DT cord-010119-t1x9gknd 12291 32 alternative alternative NN cord-010119-t1x9gknd 12291 33 that that IN cord-010119-t1x9gknd 12291 34 the the DT cord-010119-t1x9gknd 12291 35 true true JJ cord-010119-t1x9gknd 12291 36 mean mean NN cord-010119-t1x9gknd 12291 37 is be VBZ cord-010119-t1x9gknd 12291 38 > > XX cord-010119-t1x9gknd 12291 39 0 0 NFP cord-010119-t1x9gknd 12291 40 . . . cord-010119-t1x9gknd 12292 1 Overall overall JJ cord-010119-t1x9gknd 12292 2 participants participant NNS cord-010119-t1x9gknd 12292 3 had have VBD cord-010119-t1x9gknd 12292 4 favorable favorable JJ cord-010119-t1x9gknd 12292 5 opinions opinion NNS cord-010119-t1x9gknd 12292 6 of of IN cord-010119-t1x9gknd 12292 7 the the DT cord-010119-t1x9gknd 12292 8 FDA FDA NNP cord-010119-t1x9gknd 12292 9 's 's POS cord-010119-t1x9gknd 12292 10 decisions decision NNS cord-010119-t1x9gknd 12292 11 . . . cord-010119-t1x9gknd 12293 1 Statistically statistically RB cord-010119-t1x9gknd 12293 2 , , , cord-010119-t1x9gknd 12293 3 whether whether IN cord-010119-t1x9gknd 12293 4 participants participant NNS cord-010119-t1x9gknd 12293 5 in in IN cord-010119-t1x9gknd 12293 6 different different JJ cord-010119-t1x9gknd 12293 7 levels level NNS cord-010119-t1x9gknd 12293 8 of of IN cord-010119-t1x9gknd 12293 9 the the DT cord-010119-t1x9gknd 12293 10 demographic demographic JJ cord-010119-t1x9gknd 12293 11 variables variable NNS cord-010119-t1x9gknd 12293 12 ( ( -LRB- cord-010119-t1x9gknd 12293 13 region region NN cord-010119-t1x9gknd 12293 14 , , , cord-010119-t1x9gknd 12293 15 profession profession NN cord-010119-t1x9gknd 12293 16 , , , cord-010119-t1x9gknd 12293 17 and and CC cord-010119-t1x9gknd 12293 18 years year NNS cord-010119-t1x9gknd 12293 19 of of IN cord-010119-t1x9gknd 12293 20 experience experience NN cord-010119-t1x9gknd 12293 21 ) ) -RRB- cord-010119-t1x9gknd 12293 22 answer answer VBP cord-010119-t1x9gknd 12293 23 significantly significantly RB cord-010119-t1x9gknd 12293 24 differently differently RB cord-010119-t1x9gknd 12293 25 , , , cord-010119-t1x9gknd 12293 26 one one CD cord-010119-t1x9gknd 12293 27 way way NN cord-010119-t1x9gknd 12293 28 ANOVA ANOVA NNP cord-010119-t1x9gknd 12293 29 models model NNS cord-010119-t1x9gknd 12293 30 were be VBD cord-010119-t1x9gknd 12293 31 used use VBN cord-010119-t1x9gknd 12293 32 with with IN cord-010119-t1x9gknd 12293 33 Likert Likert NNP cord-010119-t1x9gknd 12293 34 - - HYPH cord-010119-t1x9gknd 12293 35 scale scale NN cord-010119-t1x9gknd 12293 36 question question NN cord-010119-t1x9gknd 12293 37 responses response NNS cord-010119-t1x9gknd 12293 38 as as IN cord-010119-t1x9gknd 12293 39 if if IN cord-010119-t1x9gknd 12293 40 they -PRON- PRP cord-010119-t1x9gknd 12293 41 were be VBD cord-010119-t1x9gknd 12293 42 continuous continuous JJ cord-010119-t1x9gknd 12293 43 . . . cord-010119-t1x9gknd 12294 1 The the DT cord-010119-t1x9gknd 12294 2 F F NNP cord-010119-t1x9gknd 12294 3 - - HYPH cord-010119-t1x9gknd 12294 4 statistic statistic NN cord-010119-t1x9gknd 12294 5 and and CC cord-010119-t1x9gknd 12294 6 P p NN cord-010119-t1x9gknd 12294 7 - - HYPH cord-010119-t1x9gknd 12294 8 value value NN cord-010119-t1x9gknd 12294 9 are be VBP cord-010119-t1x9gknd 12294 10 for for IN cord-010119-t1x9gknd 12294 11 the the DT cord-010119-t1x9gknd 12294 12 null null JJ cord-010119-t1x9gknd 12294 13 hypothesis hypothesis NN cord-010119-t1x9gknd 12294 14 that that IN cord-010119-t1x9gknd 12294 15 all all DT cord-010119-t1x9gknd 12294 16 levels level NNS cord-010119-t1x9gknd 12294 17 of of IN cord-010119-t1x9gknd 12294 18 the the DT cord-010119-t1x9gknd 12294 19 explanatory explanatory JJ cord-010119-t1x9gknd 12294 20 variable variable NN cord-010119-t1x9gknd 12294 21 have have VBP cord-010119-t1x9gknd 12294 22 the the DT cord-010119-t1x9gknd 12294 23 same same JJ cord-010119-t1x9gknd 12294 24 mean mean NN cord-010119-t1x9gknd 12294 25 for for IN cord-010119-t1x9gknd 12294 26 the the DT cord-010119-t1x9gknd 12294 27 response response NN cord-010119-t1x9gknd 12294 28 variable variable NN cord-010119-t1x9gknd 12294 29 . . . cord-010119-t1x9gknd 12295 1 There there EX cord-010119-t1x9gknd 12295 2 were be VBD cord-010119-t1x9gknd 12295 3 no no DT cord-010119-t1x9gknd 12295 4 significant significant JJ cord-010119-t1x9gknd 12295 5 differences difference NNS cord-010119-t1x9gknd 12295 6 in in IN cord-010119-t1x9gknd 12295 7 the the DT cord-010119-t1x9gknd 12295 8 years year NNS cord-010119-t1x9gknd 12295 9 of of IN cord-010119-t1x9gknd 12295 10 experience experience NN cord-010119-t1x9gknd 12295 11 and and CC cord-010119-t1x9gknd 12295 12 profession profession NN cord-010119-t1x9gknd 12295 13 variables variable NNS cord-010119-t1x9gknd 12295 14 for for IN cord-010119-t1x9gknd 12295 15 participants participant NNS cord-010119-t1x9gknd 12295 16 . . . cord-010119-t1x9gknd 12296 1 Region region NN cord-010119-t1x9gknd 12296 2 was be VBD cord-010119-t1x9gknd 12296 3 determined determine VBN cord-010119-t1x9gknd 12296 4 to to TO cord-010119-t1x9gknd 12296 5 be be VB cord-010119-t1x9gknd 12296 6 unreliable unreliable JJ cord-010119-t1x9gknd 12296 7 due due IN cord-010119-t1x9gknd 12296 8 to to IN cord-010119-t1x9gknd 12296 9 undefined undefined JJ cord-010119-t1x9gknd 12296 10 states state NNS cord-010119-t1x9gknd 12296 11 for for IN cord-010119-t1x9gknd 12296 12 each each DT cord-010119-t1x9gknd 12296 13 region region NN cord-010119-t1x9gknd 12296 14 listed list VBN cord-010119-t1x9gknd 12296 15 . . . cord-010119-t1x9gknd 12297 1 Conclusion conclusion NN cord-010119-t1x9gknd 12297 2 : : : cord-010119-t1x9gknd 12298 1 The the DT cord-010119-t1x9gknd 12298 2 research research NN cord-010119-t1x9gknd 12298 3 revealed reveal VBD cord-010119-t1x9gknd 12298 4 that that IN cord-010119-t1x9gknd 12298 5 industry industry NN cord-010119-t1x9gknd 12298 6 experts expert NNS cord-010119-t1x9gknd 12298 7 conclude conclude VBP cord-010119-t1x9gknd 12298 8 that that IN cord-010119-t1x9gknd 12298 9 the the DT cord-010119-t1x9gknd 12298 10 current current JJ cord-010119-t1x9gknd 12298 11 system system NN cord-010119-t1x9gknd 12298 12 of of IN cord-010119-t1x9gknd 12298 13 DHQ DHQ NNP cord-010119-t1x9gknd 12298 14 and and CC cord-010119-t1x9gknd 12298 15 FDA FDA NNP cord-010119-t1x9gknd 12298 16 guidance guidance NN cord-010119-t1x9gknd 12298 17 documents document NNS cord-010119-t1x9gknd 12298 18 , , , cord-010119-t1x9gknd 12298 19 if if IN cord-010119-t1x9gknd 12298 20 issued issue VBN cord-010119-t1x9gknd 12298 21 timely timely RB cord-010119-t1x9gknd 12298 22 , , , cord-010119-t1x9gknd 12298 23 are be VBP cord-010119-t1x9gknd 12298 24 adequate adequate JJ cord-010119-t1x9gknd 12298 25 . . . cord-010119-t1x9gknd 12299 1 Background Background NNP cord-010119-t1x9gknd 12299 2 / / SYM cord-010119-t1x9gknd 12299 3 Case Case NNP cord-010119-t1x9gknd 12299 4 Studies Studies NNPS cord-010119-t1x9gknd 12299 5 : : : cord-010119-t1x9gknd 12299 6 When when WRB cord-010119-t1x9gknd 12299 7 evaluating evaluate VBG cord-010119-t1x9gknd 12299 8 a a DT cord-010119-t1x9gknd 12299 9 new new JJ cord-010119-t1x9gknd 12299 10 instrument instrument NN cord-010119-t1x9gknd 12299 11 solution solution NN cord-010119-t1x9gknd 12299 12 for for IN cord-010119-t1x9gknd 12299 13 pre pre JJ cord-010119-t1x9gknd 12299 14 - - JJ cord-010119-t1x9gknd 12299 15 transfusion transfusion JJ cord-010119-t1x9gknd 12299 16 testing testing NN cord-010119-t1x9gknd 12299 17 , , , cord-010119-t1x9gknd 12299 18 it -PRON- PRP cord-010119-t1x9gknd 12299 19 is be VBZ cord-010119-t1x9gknd 12299 20 important important JJ cord-010119-t1x9gknd 12299 21 to to TO cord-010119-t1x9gknd 12299 22 consider consider VB cord-010119-t1x9gknd 12299 23 the the DT cord-010119-t1x9gknd 12299 24 operational operational JJ cord-010119-t1x9gknd 12299 25 impact impact NN cord-010119-t1x9gknd 12299 26 of of IN cord-010119-t1x9gknd 12299 27 the the DT cord-010119-t1x9gknd 12299 28 system system NN cord-010119-t1x9gknd 12299 29 on on IN cord-010119-t1x9gknd 12299 30 the the DT cord-010119-t1x9gknd 12299 31 lab lab NN cord-010119-t1x9gknd 12299 32 . . . cord-010119-t1x9gknd 12300 1 There there EX cord-010119-t1x9gknd 12300 2 are be VBP cord-010119-t1x9gknd 12300 3 a a DT cord-010119-t1x9gknd 12300 4 variety variety NN cord-010119-t1x9gknd 12300 5 of of IN cord-010119-t1x9gknd 12300 6 operational operational JJ cord-010119-t1x9gknd 12300 7 , , , cord-010119-t1x9gknd 12300 8 performance performance NN cord-010119-t1x9gknd 12300 9 and and CC cord-010119-t1x9gknd 12300 10 system system NN cord-010119-t1x9gknd 12300 11 metrics metric NNS cord-010119-t1x9gknd 12300 12 that that WDT cord-010119-t1x9gknd 12300 13 can can MD cord-010119-t1x9gknd 12300 14 be be VB cord-010119-t1x9gknd 12300 15 evaluated evaluate VBN cord-010119-t1x9gknd 12300 16 to to TO cord-010119-t1x9gknd 12300 17 determine determine VB cord-010119-t1x9gknd 12300 18 this this DT cord-010119-t1x9gknd 12300 19 impact impact NN cord-010119-t1x9gknd 12300 20 including include VBG cord-010119-t1x9gknd 12300 21 : : : cord-010119-t1x9gknd 12300 22 test test NN cord-010119-t1x9gknd 12300 23 workflow workflow NN cord-010119-t1x9gknd 12300 24 , , , cord-010119-t1x9gknd 12300 25 hands hand NNS cord-010119-t1x9gknd 12300 26 on on IN cord-010119-t1x9gknd 12300 27 time time NN cord-010119-t1x9gknd 12300 28 , , , cord-010119-t1x9gknd 12300 29 and and CC cord-010119-t1x9gknd 12300 30 automation automation NN cord-010119-t1x9gknd 12300 31 time time NN cord-010119-t1x9gknd 12300 32 . . . cord-010119-t1x9gknd 12301 1 Study Study NNP cord-010119-t1x9gknd 12301 2 Design Design NNP cord-010119-t1x9gknd 12301 3 / / SYM cord-010119-t1x9gknd 12301 4 Methods method NNS cord-010119-t1x9gknd 12301 5 : : : cord-010119-t1x9gknd 12301 6 The the DT cord-010119-t1x9gknd 12301 7 study study NN cord-010119-t1x9gknd 12301 8 involved involve VBD cord-010119-t1x9gknd 12301 9 a a DT cord-010119-t1x9gknd 12301 10 current current JJ cord-010119-t1x9gknd 12301 11 state state NN cord-010119-t1x9gknd 12301 12 to to IN cord-010119-t1x9gknd 12301 13 a a DT cord-010119-t1x9gknd 12301 14 future future JJ cord-010119-t1x9gknd 12301 15 state state NN cord-010119-t1x9gknd 12301 16 comparison comparison NN cord-010119-t1x9gknd 12301 17 of of IN cord-010119-t1x9gknd 12301 18 testing testing NN cord-010119-t1x9gknd 12301 19 processes process NNS cord-010119-t1x9gknd 12301 20 with with IN cord-010119-t1x9gknd 12301 21 an an DT cord-010119-t1x9gknd 12301 22 instrument instrument NN cord-010119-t1x9gknd 12301 23 ORTHO ORTHO NNP cord-010119-t1x9gknd 12301 24 ProVueV provuev NN cord-010119-t1x9gknd 12301 25 R R NNP cord-010119-t1x9gknd 12301 26 ( ( -LRB- cord-010119-t1x9gknd 12301 27 PV PV NNP cord-010119-t1x9gknd 12301 28 ) ) -RRB- cord-010119-t1x9gknd 12301 29 and and CC cord-010119-t1x9gknd 12301 30 manual manual JJ cord-010119-t1x9gknd 12301 31 testing testing NN cord-010119-t1x9gknd 12301 32 vs. vs. IN cord-010119-t1x9gknd 12301 33 an an DT cord-010119-t1x9gknd 12301 34 instrument instrument NN cord-010119-t1x9gknd 12301 35 ORTHO ORTHO NNP cord-010119-t1x9gknd 12301 36 VISIONV VISIONV NNP cord-010119-t1x9gknd 12301 37 R R NNP cord-010119-t1x9gknd 12301 38 ( ( -LRB- cord-010119-t1x9gknd 12301 39 OV OV NNP cord-010119-t1x9gknd 12301 40 ) ) -RRB- cord-010119-t1x9gknd 12301 41 . . . cord-010119-t1x9gknd 12302 1 Data datum NNS cord-010119-t1x9gknd 12302 2 collection collection NN cord-010119-t1x9gknd 12302 3 methods method NNS cord-010119-t1x9gknd 12302 4 included include VBD cord-010119-t1x9gknd 12302 5 direct direct JJ cord-010119-t1x9gknd 12302 6 observation observation NN cord-010119-t1x9gknd 12302 7 , , , cord-010119-t1x9gknd 12302 8 time time NN cord-010119-t1x9gknd 12302 9 studies study NNS cord-010119-t1x9gknd 12302 10 , , , cord-010119-t1x9gknd 12302 11 and and CC cord-010119-t1x9gknd 12302 12 interviews interview NNS cord-010119-t1x9gknd 12302 13 . . . cord-010119-t1x9gknd 12303 1 The the DT cord-010119-t1x9gknd 12303 2 PV pv NN cord-010119-t1x9gknd 12303 3 bench bench NN cord-010119-t1x9gknd 12303 4 performs perform VBZ cord-010119-t1x9gknd 12303 5 Type type NN cord-010119-t1x9gknd 12303 6 & & CC cord-010119-t1x9gknd 12303 7 Screens Screens NNPS cord-010119-t1x9gknd 12303 8 ( ( -LRB- cord-010119-t1x9gknd 12303 9 TS TS NNP cord-010119-t1x9gknd 12303 10 ) ) -RRB- cord-010119-t1x9gknd 12303 11 on on IN cord-010119-t1x9gknd 12303 12 the the DT cord-010119-t1x9gknd 12303 13 PV PV NNP cord-010119-t1x9gknd 12303 14 and and CC cord-010119-t1x9gknd 12303 15 manual manual NNP cord-010119-t1x9gknd 12303 16 AbID AbID NNP cord-010119-t1x9gknd 12303 17 / / SYM cord-010119-t1x9gknd 12303 18 selected select VBN cord-010119-t1x9gknd 12303 19 cell cell NN cord-010119-t1x9gknd 12303 20 panels panel NNS cord-010119-t1x9gknd 12303 21 in in IN cord-010119-t1x9gknd 12303 22 the the DT cord-010119-t1x9gknd 12303 23 gel gel NN cord-010119-t1x9gknd 12303 24 test test NN cord-010119-t1x9gknd 12303 25 . . . cord-010119-t1x9gknd 12304 1 All all DT cord-010119-t1x9gknd 12304 2 other other JJ cord-010119-t1x9gknd 12304 3 testing testing NN cord-010119-t1x9gknd 12304 4 ; ; : cord-010119-t1x9gknd 12304 5 cord cord NN cord-010119-t1x9gknd 12304 6 blood(CB blood(CB NNS cord-010119-t1x9gknd 12304 7 ) ) -RRB- cord-010119-t1x9gknd 12304 8 , , , cord-010119-t1x9gknd 12304 9 DAT DAT NNP cord-010119-t1x9gknd 12304 10 , , , cord-010119-t1x9gknd 12304 11 unit unit NN cord-010119-t1x9gknd 12304 12 confirm(UC confirm(UC NNP cord-010119-t1x9gknd 12304 13 ) ) -RRB- cord-010119-t1x9gknd 12304 14 , , , cord-010119-t1x9gknd 12304 15 patient patient JJ cord-010119-t1x9gknd 12304 16 type type NN cord-010119-t1x9gknd 12304 17 confirm(PC confirm(PC NNP cord-010119-t1x9gknd 12304 18 ) ) -RRB- cord-010119-t1x9gknd 12304 19 and and CC cord-010119-t1x9gknd 12304 20 crossmatch(XM crossmatch(xm JJ cord-010119-t1x9gknd 12304 21 ) ) -RRB- cord-010119-t1x9gknd 12304 22 , , , cord-010119-t1x9gknd 12304 23 etc etc FW cord-010119-t1x9gknd 12304 24 . . NN cord-010119-t1x9gknd 12304 25 are be VBP cord-010119-t1x9gknd 12304 26 done do VBN cord-010119-t1x9gknd 12304 27 manually manually RB cord-010119-t1x9gknd 12304 28 in in IN cord-010119-t1x9gknd 12304 29 tube tube NN cord-010119-t1x9gknd 12304 30 . . . cord-010119-t1x9gknd 12305 1 The the DT cord-010119-t1x9gknd 12305 2 future future JJ cord-010119-t1x9gknd 12305 3 state state NN cord-010119-t1x9gknd 12305 4 incorporated incorporate VBD cord-010119-t1x9gknd 12305 5 the the DT cord-010119-t1x9gknd 12305 6 OV OV NNP cord-010119-t1x9gknd 12305 7 . . . cord-010119-t1x9gknd 12306 1 TS TS NNP cord-010119-t1x9gknd 12306 2 , , , cord-010119-t1x9gknd 12306 3 AbID AbID NNP cord-010119-t1x9gknd 12306 4 and and CC cord-010119-t1x9gknd 12306 5 UC UC NNP cord-010119-t1x9gknd 12306 6 were be VBD cord-010119-t1x9gknd 12306 7 evaluated evaluate VBN cord-010119-t1x9gknd 12306 8 in in IN cord-010119-t1x9gknd 12306 9 both both DT cord-010119-t1x9gknd 12306 10 states state NNS cord-010119-t1x9gknd 12306 11 . . . cord-010119-t1x9gknd 12307 1 Cycle cycle NN cord-010119-t1x9gknd 12307 2 time(CT time(CT NNP cord-010119-t1x9gknd 12307 3 ) ) -RRB- cord-010119-t1x9gknd 12307 4 was be VBD cord-010119-t1x9gknd 12307 5 averaged average VBN cord-010119-t1x9gknd 12307 6 based base VBN cord-010119-t1x9gknd 12307 7 on on IN cord-010119-t1x9gknd 12307 8 3 3 CD cord-010119-t1x9gknd 12307 9 run run NN cord-010119-t1x9gknd 12307 10 cycles cycle NNS cord-010119-t1x9gknd 12307 11 . . . cord-010119-t1x9gknd 12308 1 CT CT NNP cord-010119-t1x9gknd 12308 2 was be VBD cord-010119-t1x9gknd 12308 3 comprised comprise VBN cord-010119-t1x9gknd 12308 4 of of IN cord-010119-t1x9gknd 12308 5 3 3 CD cord-010119-t1x9gknd 12308 6 metrics metric NNS cord-010119-t1x9gknd 12308 7 ; ; : cord-010119-t1x9gknd 12308 8 instrument instrument NN cord-010119-t1x9gknd 12308 9 time(IT time(IT NNP cord-010119-t1x9gknd 12308 10 ) ) -RRB- cord-010119-t1x9gknd 12308 11 , , , cord-010119-t1x9gknd 12308 12 standby standby NN cord-010119-t1x9gknd 12308 13 time(ST time(st NN cord-010119-t1x9gknd 12308 14 ) ) -RRB- cord-010119-t1x9gknd 12308 15 and and CC cord-010119-t1x9gknd 12308 16 labor labor NN cord-010119-t1x9gknd 12308 17 time(LT time(LT NNP cord-010119-t1x9gknd 12308 18 ) ) -RRB- cord-010119-t1x9gknd 12308 19 . . . cord-010119-t1x9gknd 12309 1 ST ST NNP cord-010119-t1x9gknd 12309 2 may may MD cord-010119-t1x9gknd 12309 3 be be VB cord-010119-t1x9gknd 12309 4 comprised comprise VBN cord-010119-t1x9gknd 12309 5 of of IN cord-010119-t1x9gknd 12309 6 2 2 CD cord-010119-t1x9gknd 12309 7 components component NNS cord-010119-t1x9gknd 12309 8 , , , cord-010119-t1x9gknd 12309 9 time time NN cord-010119-t1x9gknd 12309 10 that that WDT cord-010119-t1x9gknd 12309 11 could could MD cord-010119-t1x9gknd 12309 12 be be VB cord-010119-t1x9gknd 12309 13 utilized utilize VBN cord-010119-t1x9gknd 12309 14 as as IN cord-010119-t1x9gknd 12309 15 " " `` cord-010119-t1x9gknd 12309 16 walkaway walkaway JJ cord-010119-t1x9gknd 12309 17 " " '' cord-010119-t1x9gknd 12309 18 time time NN cord-010119-t1x9gknd 12309 19 or or CC cord-010119-t1x9gknd 12309 20 vigilant vigilant JJ cord-010119-t1x9gknd 12309 21 time time NN cord-010119-t1x9gknd 12309 22 ( ( -LRB- cord-010119-t1x9gknd 12309 23 VT VT NNP cord-010119-t1x9gknd 12309 24 ) ) -RRB- cord-010119-t1x9gknd 12309 25 which which WDT cord-010119-t1x9gknd 12309 26 requires require VBZ cord-010119-t1x9gknd 12309 27 operator operator NN cord-010119-t1x9gknd 12309 28 presence presence NN cord-010119-t1x9gknd 12309 29 but but CC cord-010119-t1x9gknd 12309 30 not not RB cord-010119-t1x9gknd 12309 31 operator operator NN cord-010119-t1x9gknd 12309 32 action action NN cord-010119-t1x9gknd 12309 33 . . . cord-010119-t1x9gknd 12310 1 For for IN cord-010119-t1x9gknd 12310 2 automated automate VBN cord-010119-t1x9gknd 12310 3 instruments instrument NNS cord-010119-t1x9gknd 12310 4 , , , cord-010119-t1x9gknd 12310 5 VT VT NNP cord-010119-t1x9gknd 12310 6 for for IN cord-010119-t1x9gknd 12310 7 each each DT cord-010119-t1x9gknd 12310 8 cycle cycle NN cord-010119-t1x9gknd 12310 9 was be VBD cord-010119-t1x9gknd 12310 10 measured measure VBN cord-010119-t1x9gknd 12310 11 as as IN cord-010119-t1x9gknd 12310 12 instrument instrument NN cord-010119-t1x9gknd 12310 13 access access NN cord-010119-t1x9gknd 12310 14 unavailable unavailable JJ cord-010119-t1x9gknd 12310 15 . . . cord-010119-t1x9gknd 12311 1 Instrument instrument NN cord-010119-t1x9gknd 12311 2 daily daily JJ cord-010119-t1x9gknd 12311 3 maintenance maintenance NN cord-010119-t1x9gknd 12311 4 ( ( -LRB- cord-010119-t1x9gknd 12311 5 DM DM NNP cord-010119-t1x9gknd 12311 6 ) ) -RRB- cord-010119-t1x9gknd 12311 7 CT CT NNP cord-010119-t1x9gknd 12311 8 was be VBD cord-010119-t1x9gknd 12311 9 evaluated evaluate VBN cord-010119-t1x9gknd 12311 10 as as RB cord-010119-t1x9gknd 12311 11 well well RB cord-010119-t1x9gknd 12311 12 . . . cord-010119-t1x9gknd 12312 1 Similarly similarly RB cord-010119-t1x9gknd 12312 2 , , , cord-010119-t1x9gknd 12312 3 timing timing NN cord-010119-t1x9gknd 12312 4 of of IN cord-010119-t1x9gknd 12312 5 manual manual JJ cord-010119-t1x9gknd 12312 6 tube tube NN cord-010119-t1x9gknd 12312 7 test test NN cord-010119-t1x9gknd 12312 8 processes process NNS cord-010119-t1x9gknd 12312 9 used use VBD cord-010119-t1x9gknd 12312 10 these these DT cord-010119-t1x9gknd 12312 11 metrics metric NNS cord-010119-t1x9gknd 12312 12 . . . cord-010119-t1x9gknd 12313 1 For for IN cord-010119-t1x9gknd 12313 2 repetitive repetitive JJ cord-010119-t1x9gknd 12313 3 activities activity NNS cord-010119-t1x9gknd 12313 4 within within IN cord-010119-t1x9gknd 12313 5 a a DT cord-010119-t1x9gknd 12313 6 process process NN cord-010119-t1x9gknd 12313 7 , , , cord-010119-t1x9gknd 12313 8 such such JJ cord-010119-t1x9gknd 12313 9 as as IN cord-010119-t1x9gknd 12313 10 UC UC NNP cord-010119-t1x9gknd 12313 11 or or CC cord-010119-t1x9gknd 12313 12 XM XM NNP cord-010119-t1x9gknd 12313 13 , , , cord-010119-t1x9gknd 12313 14 a a DT cord-010119-t1x9gknd 12313 15 time time NN cord-010119-t1x9gknd 12313 16 per per IN cord-010119-t1x9gknd 12313 17 individual individual JJ cord-010119-t1x9gknd 12313 18 process process NN cord-010119-t1x9gknd 12313 19 was be VBD cord-010119-t1x9gknd 12313 20 captured capture VBN cord-010119-t1x9gknd 12313 21 and and CC cord-010119-t1x9gknd 12313 22 then then RB cord-010119-t1x9gknd 12313 23 multiplied multiply VBN cord-010119-t1x9gknd 12313 24 per per IN cord-010119-t1x9gknd 12313 25 unit unit NN cord-010119-t1x9gknd 12313 26 . . . cord-010119-t1x9gknd 12314 1 Results result NNS cord-010119-t1x9gknd 12314 2 / / SYM cord-010119-t1x9gknd 12314 3 Findings finding NNS cord-010119-t1x9gknd 12314 4 : : : cord-010119-t1x9gknd 12315 1 Table table NN cord-010119-t1x9gknd 12315 2 1 1 CD cord-010119-t1x9gknd 12315 3 provides provide VBZ cord-010119-t1x9gknd 12315 4 details detail NNS cord-010119-t1x9gknd 12315 5 about about IN cord-010119-t1x9gknd 12315 6 the the DT cord-010119-t1x9gknd 12315 7 metrics metric NNS cord-010119-t1x9gknd 12315 8 of of IN cord-010119-t1x9gknd 12315 9 current current JJ cord-010119-t1x9gknd 12315 10 state state NN cord-010119-t1x9gknd 12315 11 and and CC cord-010119-t1x9gknd 12315 12 future future JJ cord-010119-t1x9gknd 12315 13 state state NN cord-010119-t1x9gknd 12315 14 processes process NNS cord-010119-t1x9gknd 12315 15 . . . cord-010119-t1x9gknd 12316 1 Tube tube NN cord-010119-t1x9gknd 12316 2 based base VBN cord-010119-t1x9gknd 12316 3 test test NN cord-010119-t1x9gknd 12316 4 timing timing NN cord-010119-t1x9gknd 12316 5 is be VBZ cord-010119-t1x9gknd 12316 6 as as IN cord-010119-t1x9gknd 12316 7 follows follow VBZ cord-010119-t1x9gknd 12316 8 : : : cord-010119-t1x9gknd 12316 9 PC pc NN cord-010119-t1x9gknd 12316 10 ( ( -LRB- cord-010119-t1x9gknd 12316 11 2:50 2:50 CD cord-010119-t1x9gknd 12316 12 ) ) -RRB- cord-010119-t1x9gknd 12316 13 , , , cord-010119-t1x9gknd 12316 14 XM XM NNP cord-010119-t1x9gknd 12316 15 ( ( -LRB- cord-010119-t1x9gknd 12316 16 32:23 32:23 CD cord-010119-t1x9gknd 12316 17 ) ) -RRB- cord-010119-t1x9gknd 12316 18 , , , cord-010119-t1x9gknd 12316 19 CB CB NNP cord-010119-t1x9gknd 12316 20 ( ( -LRB- cord-010119-t1x9gknd 12316 21 13:18 13:18 CD cord-010119-t1x9gknd 12316 22 ) ) -RRB- cord-010119-t1x9gknd 12316 23 and and CC cord-010119-t1x9gknd 12316 24 DAT DAT NNP cord-010119-t1x9gknd 12316 25 ( ( -LRB- cord-010119-t1x9gknd 12316 26 10:00 10:00 CD cord-010119-t1x9gknd 12316 27 ) ) -RRB- cord-010119-t1x9gknd 12316 28 . . . cord-010119-t1x9gknd 12317 1 By by IN cord-010119-t1x9gknd 12317 2 implementing implement VBG cord-010119-t1x9gknd 12317 3 the the DT cord-010119-t1x9gknd 12317 4 future future JJ cord-010119-t1x9gknd 12317 5 state state NN cord-010119-t1x9gknd 12317 6 , , , cord-010119-t1x9gknd 12317 7 an an DT cord-010119-t1x9gknd 12317 8 average average JJ cord-010119-t1x9gknd 12317 9 $ $ $ cord-010119-t1x9gknd 12317 10 1.3 1.3 CD cord-010119-t1x9gknd 12317 11 min min NN cord-010119-t1x9gknd 12317 12 . . . cord-010119-t1x9gknd 12318 1 LT LT NNP cord-010119-t1x9gknd 12318 2 and and CC cord-010119-t1x9gknd 12318 3 VT VT NNP cord-010119-t1x9gknd 12318 4 is be VBZ cord-010119-t1x9gknd 12318 5 saved save VBN cord-010119-t1x9gknd 12318 6 on on IN cord-010119-t1x9gknd 12318 7 each each DT cord-010119-t1x9gknd 12318 8 sample sample NN cord-010119-t1x9gknd 12318 9 loaded load VBN cord-010119-t1x9gknd 12318 10 for for IN cord-010119-t1x9gknd 12318 11 TS ts NN cord-010119-t1x9gknd 12318 12 equating equate VBG cord-010119-t1x9gknd 12318 13 to to IN cord-010119-t1x9gknd 12318 14 a a DT cord-010119-t1x9gknd 12318 15 73 73 CD cord-010119-t1x9gknd 12318 16 % % NN cord-010119-t1x9gknd 12318 17 labor labor NN cord-010119-t1x9gknd 12318 18 reduction reduction NN cord-010119-t1x9gknd 12318 19 over over IN cord-010119-t1x9gknd 12318 20 the the DT cord-010119-t1x9gknd 12318 21 current current JJ cord-010119-t1x9gknd 12318 22 state state NN cord-010119-t1x9gknd 12318 23 . . . cord-010119-t1x9gknd 12319 1 A a DT cord-010119-t1x9gknd 12319 2 19 19 CD cord-010119-t1x9gknd 12319 3 % % NN cord-010119-t1x9gknd 12319 4 improvement improvement NN cord-010119-t1x9gknd 12319 5 in in IN cord-010119-t1x9gknd 12319 6 TAT tat NN cord-010119-t1x9gknd 12319 7 on on IN cord-010119-t1x9gknd 12319 8 the the DT cord-010119-t1x9gknd 12319 9 TS TS NNP cord-010119-t1x9gknd 12319 10 was be VBD cord-010119-t1x9gknd 12319 11 achieved achieve VBN cord-010119-t1x9gknd 12319 12 in in IN cord-010119-t1x9gknd 12319 13 the the DT cord-010119-t1x9gknd 12319 14 future future JJ cord-010119-t1x9gknd 12319 15 state state NN cord-010119-t1x9gknd 12319 16 . . . cord-010119-t1x9gknd 12320 1 Moving move VBG cord-010119-t1x9gknd 12320 2 from from IN cord-010119-t1x9gknd 12320 3 manual manual JJ cord-010119-t1x9gknd 12320 4 AbID AbID NNP cord-010119-t1x9gknd 12320 5 to to IN cord-010119-t1x9gknd 12320 6 automated automate VBN cord-010119-t1x9gknd 12320 7 processing processing NN cord-010119-t1x9gknd 12320 8 resulted result VBD cord-010119-t1x9gknd 12320 9 in in IN cord-010119-t1x9gknd 12320 10 a a DT cord-010119-t1x9gknd 12320 11 59 59 CD cord-010119-t1x9gknd 12320 12 % % NN cord-010119-t1x9gknd 12320 13 LT LT NNP cord-010119-t1x9gknd 12320 14 reduction reduction NN cord-010119-t1x9gknd 12320 15 . . . cord-010119-t1x9gknd 12321 1 On on IN cord-010119-t1x9gknd 12321 2 average average JJ cord-010119-t1x9gknd 12321 3 , , , cord-010119-t1x9gknd 12321 4 a a DT cord-010119-t1x9gknd 12321 5 38 38 CD cord-010119-t1x9gknd 12321 6 min min NN cord-010119-t1x9gknd 12321 7 . . . cord-010119-t1x9gknd 12321 8 continuous continuous JJ cord-010119-t1x9gknd 12321 9 walk walk NN cord-010119-t1x9gknd 12321 10 - - HYPH cord-010119-t1x9gknd 12321 11 away away RP cord-010119-t1x9gknd 12321 12 time time NN cord-010119-t1x9gknd 12321 13 is be VBZ cord-010119-t1x9gknd 12321 14 achieved achieve VBN cord-010119-t1x9gknd 12321 15 for for IN cord-010119-t1x9gknd 12321 16 each each DT cord-010119-t1x9gknd 12321 17 automated automate VBN cord-010119-t1x9gknd 12321 18 AbID abid NN cord-010119-t1x9gknd 12321 19 . . . cord-010119-t1x9gknd 12322 1 UC UC NNP cord-010119-t1x9gknd 12322 2 had have VBD cord-010119-t1x9gknd 12322 3 less less JJR cord-010119-t1x9gknd 12322 4 impact impact NN cord-010119-t1x9gknd 12322 5 on on IN cord-010119-t1x9gknd 12322 6 labor labor NN cord-010119-t1x9gknd 12322 7 time time NN cord-010119-t1x9gknd 12322 8 with with IN cord-010119-t1x9gknd 12322 9 minimal minimal JJ cord-010119-t1x9gknd 12322 10 difference difference NN cord-010119-t1x9gknd 12322 11 however however RB cord-010119-t1x9gknd 12322 12 allowed allow VBN cord-010119-t1x9gknd 12322 13 for for IN cord-010119-t1x9gknd 12322 14 focus focus NN cord-010119-t1x9gknd 12322 15 on on IN cord-010119-t1x9gknd 12322 16 consistency consistency NN cord-010119-t1x9gknd 12322 17 and and CC cord-010119-t1x9gknd 12322 18 quality quality NN cord-010119-t1x9gknd 12322 19 metrics metric NNS cord-010119-t1x9gknd 12322 20 . . . cord-010119-t1x9gknd 12323 1 Conclusion conclusion NN cord-010119-t1x9gknd 12323 2 : : : cord-010119-t1x9gknd 12324 1 Based base VBN cord-010119-t1x9gknd 12324 2 on on IN cord-010119-t1x9gknd 12324 3 the the DT cord-010119-t1x9gknd 12324 4 metrics metric NNS cord-010119-t1x9gknd 12324 5 evaluated evaluate VBN cord-010119-t1x9gknd 12324 6 and and CC cord-010119-t1x9gknd 12324 7 compared compare VBN cord-010119-t1x9gknd 12324 8 between between IN cord-010119-t1x9gknd 12324 9 current current JJ cord-010119-t1x9gknd 12324 10 state state NN cord-010119-t1x9gknd 12324 11 and and CC cord-010119-t1x9gknd 12324 12 future future JJ cord-010119-t1x9gknd 12324 13 state state NN cord-010119-t1x9gknd 12324 14 , , , cord-010119-t1x9gknd 12324 15 the the DT cord-010119-t1x9gknd 12324 16 OV OV NNP cord-010119-t1x9gknd 12324 17 has have VBZ cord-010119-t1x9gknd 12324 18 demonstrated demonstrate VBN cord-010119-t1x9gknd 12324 19 improvement improvement NN cord-010119-t1x9gknd 12324 20 in in IN cord-010119-t1x9gknd 12324 21 lab lab NN cord-010119-t1x9gknd 12324 22 operations operation NNS cord-010119-t1x9gknd 12324 23 to to IN cord-010119-t1x9gknd 12324 24 both both CC cord-010119-t1x9gknd 12324 25 the the DT cord-010119-t1x9gknd 12324 26 labor labor NN cord-010119-t1x9gknd 12324 27 required require VBN cord-010119-t1x9gknd 12324 28 and and CC cord-010119-t1x9gknd 12324 29 result result VB cord-010119-t1x9gknd 12324 30 TAT tat NN cord-010119-t1x9gknd 12324 31 delivery delivery NN cord-010119-t1x9gknd 12324 32 . . . cord-010119-t1x9gknd 12325 1 Opportunity opportunity NN cord-010119-t1x9gknd 12325 2 exists exist VBZ cord-010119-t1x9gknd 12325 3 to to TO cord-010119-t1x9gknd 12325 4 automate automate VB cord-010119-t1x9gknd 12325 5 workflows workflow NNS cord-010119-t1x9gknd 12325 6 on on IN cord-010119-t1x9gknd 12325 7 other other JJ cord-010119-t1x9gknd 12325 8 tests test NNS cord-010119-t1x9gknd 12325 9 that that WDT cord-010119-t1x9gknd 12325 10 are be VBP cord-010119-t1x9gknd 12325 11 still still RB cord-010119-t1x9gknd 12325 12 manually manually RB cord-010119-t1x9gknd 12325 13 performed perform VBN cord-010119-t1x9gknd 12325 14 . . . cord-010119-t1x9gknd 12326 1 Background Background NNP cord-010119-t1x9gknd 12326 2 / / SYM cord-010119-t1x9gknd 12326 3 Case Case NNP cord-010119-t1x9gknd 12326 4 Studies Studies NNPS cord-010119-t1x9gknd 12326 5 : : : cord-010119-t1x9gknd 12326 6 High high JJ cord-010119-t1x9gknd 12326 7 throughput throughput NN cord-010119-t1x9gknd 12326 8 and and CC cord-010119-t1x9gknd 12326 9 efficient efficient JJ cord-010119-t1x9gknd 12326 10 automation automation NN cord-010119-t1x9gknd 12326 11 of of IN cord-010119-t1x9gknd 12326 12 serologic serologic NNP cord-010119-t1x9gknd 12326 13 tests test NNS cord-010119-t1x9gknd 12326 14 is be VBZ cord-010119-t1x9gknd 12326 15 crucial crucial JJ cord-010119-t1x9gknd 12326 16 in in IN cord-010119-t1x9gknd 12326 17 the the DT cord-010119-t1x9gknd 12326 18 workflow workflow NN cord-010119-t1x9gknd 12326 19 of of IN cord-010119-t1x9gknd 12326 20 a a DT cord-010119-t1x9gknd 12326 21 blood blood NN cord-010119-t1x9gknd 12326 22 bank bank NN cord-010119-t1x9gknd 12326 23 that that WDT cord-010119-t1x9gknd 12326 24 tests test VBZ cord-010119-t1x9gknd 12326 25 $ $ $ cord-010119-t1x9gknd 12326 26 100 100 CD cord-010119-t1x9gknd 12326 27 type type NN cord-010119-t1x9gknd 12326 28 and and CC cord-010119-t1x9gknd 12326 29 screen screen NN cord-010119-t1x9gknd 12326 30 samples sample NNS cord-010119-t1x9gknd 12326 31 per per IN cord-010119-t1x9gknd 12326 32 day day NN cord-010119-t1x9gknd 12326 33 . . . cord-010119-t1x9gknd 12327 1 The the DT cord-010119-t1x9gknd 12327 2 ErytraV ErytraV NNS cord-010119-t1x9gknd 12327 3 R r NN cord-010119-t1x9gknd 12327 4 ( ( -LRB- cord-010119-t1x9gknd 12327 5 Grifols Grifols NNP cord-010119-t1x9gknd 12327 6 ) ) -RRB- cord-010119-t1x9gknd 12327 7 is be VBZ cord-010119-t1x9gknd 12327 8 a a DT cord-010119-t1x9gknd 12327 9 fully fully RB cord-010119-t1x9gknd 12327 10 - - HYPH cord-010119-t1x9gknd 12327 11 automated automate VBN cord-010119-t1x9gknd 12327 12 walkaway walkaway NN cord-010119-t1x9gknd 12327 13 analyzer analyzer NN cord-010119-t1x9gknd 12327 14 utilizing utilize VBG cord-010119-t1x9gknd 12327 15 8-column 8-column CD cord-010119-t1x9gknd 12327 16 gel gel NN cord-010119-t1x9gknd 12327 17 cards card NNS cord-010119-t1x9gknd 12327 18 for for IN cord-010119-t1x9gknd 12327 19 pretransfusion pretransfusion NN cord-010119-t1x9gknd 12327 20 testing testing NN cord-010119-t1x9gknd 12327 21 . . . cord-010119-t1x9gknd 12328 1 The the DT cord-010119-t1x9gknd 12328 2 blood blood NN cord-010119-t1x9gknd 12328 3 bank bank NN cord-010119-t1x9gknd 12328 4 validated validate VBD cord-010119-t1x9gknd 12328 5 and and CC cord-010119-t1x9gknd 12328 6 implemented implement VBD cord-010119-t1x9gknd 12328 7 the the DT cord-010119-t1x9gknd 12328 8 use use NN cord-010119-t1x9gknd 12328 9 of of IN cord-010119-t1x9gknd 12328 10 ErytraV ErytraV NNS cord-010119-t1x9gknd 12328 11 R r NN cord-010119-t1x9gknd 12328 12 for for IN cord-010119-t1x9gknd 12328 13 ABO ABO NNP cord-010119-t1x9gknd 12328 14 / / SYM cord-010119-t1x9gknd 12328 15 D d NN cord-010119-t1x9gknd 12328 16 typing typing NN cord-010119-t1x9gknd 12328 17 , , , cord-010119-t1x9gknd 12328 18 antibody antibody NN cord-010119-t1x9gknd 12328 19 screening screening NN cord-010119-t1x9gknd 12328 20 and and CC cord-010119-t1x9gknd 12328 21 identification identification NN cord-010119-t1x9gknd 12328 22 of of IN cord-010119-t1x9gknd 12328 23 patient patient NN cord-010119-t1x9gknd 12328 24 samples sample NNS cord-010119-t1x9gknd 12328 25 as as IN cord-010119-t1x9gknd 12328 26 a a DT cord-010119-t1x9gknd 12328 27 replacement replacement NN cord-010119-t1x9gknd 12328 28 for for IN cord-010119-t1x9gknd 12328 29 a a DT cord-010119-t1x9gknd 12328 30 solid solid JJ cord-010119-t1x9gknd 12328 31 phase phase NN cord-010119-t1x9gknd 12328 32 testing test VBG cord-010119-t1x9gknd 12328 33 platform platform NN cord-010119-t1x9gknd 12328 34 . . . cord-010119-t1x9gknd 12329 1 The the DT cord-010119-t1x9gknd 12329 2 blood blood NN cord-010119-t1x9gknd 12329 3 bank bank NN cord-010119-t1x9gknd 12329 4 also also RB cord-010119-t1x9gknd 12329 5 validated validate VBD cord-010119-t1x9gknd 12329 6 automation automation NN cord-010119-t1x9gknd 12329 7 of of IN cord-010119-t1x9gknd 12329 8 donor donor NN cord-010119-t1x9gknd 12329 9 unit unit NN cord-010119-t1x9gknd 12329 10 retypes retype VBZ cord-010119-t1x9gknd 12329 11 . . . cord-010119-t1x9gknd 12330 1 The the DT cord-010119-t1x9gknd 12330 2 instrument instrument NN cord-010119-t1x9gknd 12330 3 has have VBZ cord-010119-t1x9gknd 12330 4 bidirectional bidirectional JJ cord-010119-t1x9gknd 12330 5 interface interface NN cord-010119-t1x9gknd 12330 6 to to IN cord-010119-t1x9gknd 12330 7 the the DT cord-010119-t1x9gknd 12330 8 blood blood NN cord-010119-t1x9gknd 12330 9 bank bank NN cord-010119-t1x9gknd 12330 10 lab lab NN cord-010119-t1x9gknd 12330 11 information information NN cord-010119-t1x9gknd 12330 12 system system NN cord-010119-t1x9gknd 12330 13 ( ( -LRB- cord-010119-t1x9gknd 12330 14 LIS LIS NNP cord-010119-t1x9gknd 12330 15 ) ) -RRB- cord-010119-t1x9gknd 12330 16 , , , cord-010119-t1x9gknd 12330 17 HCLL HCLL NNP cord-010119-t1x9gknd 12330 18 TM TM NNP cord-010119-t1x9gknd 12330 19 ( ( -LRB- cord-010119-t1x9gknd 12330 20 Hemocare Hemocare NNP cord-010119-t1x9gknd 12330 21 Life Life NNP cord-010119-t1x9gknd 12330 22 Line Line NNP cord-010119-t1x9gknd 12330 23 , , , cord-010119-t1x9gknd 12330 24 Mediware Mediware NNP cord-010119-t1x9gknd 12330 25 ) ) -RRB- cord-010119-t1x9gknd 12330 26 . . . cord-010119-t1x9gknd 12331 1 Instrument instrument NN cord-010119-t1x9gknd 12331 2 validation validation NN cord-010119-t1x9gknd 12331 3 and and CC cord-010119-t1x9gknd 12331 4 implementation implementation NN cord-010119-t1x9gknd 12331 5 were be VBD cord-010119-t1x9gknd 12331 6 done do VBN cord-010119-t1x9gknd 12331 7 in in IN cord-010119-t1x9gknd 12331 8 conjunction conjunction NN cord-010119-t1x9gknd 12331 9 with with IN cord-010119-t1x9gknd 12331 10 the the DT cord-010119-t1x9gknd 12331 11 software software NN cord-010119-t1x9gknd 12331 12 version version NN cord-010119-t1x9gknd 12331 13 upgrade upgrade NN cord-010119-t1x9gknd 12331 14 of of IN cord-010119-t1x9gknd 12331 15 HCLL HCLL NNP cord-010119-t1x9gknd 12331 16 TM TM NNP cord-010119-t1x9gknd 12331 17 and and CC cord-010119-t1x9gknd 12331 18 an an DT cord-010119-t1x9gknd 12331 19 interface interface NN cord-010119-t1x9gknd 12331 20 system system NN cord-010119-t1x9gknd 12331 21 change change NN cord-010119-t1x9gknd 12331 22 to to IN cord-010119-t1x9gknd 12331 23 Maestro Maestro NNP cord-010119-t1x9gknd 12331 24 TM TM NNP cord-010119-t1x9gknd 12331 25 . . . cord-010119-t1x9gknd 12332 1 Study Study NNP cord-010119-t1x9gknd 12332 2 Design Design NNP cord-010119-t1x9gknd 12332 3 / / SYM cord-010119-t1x9gknd 12332 4 Method method NN cord-010119-t1x9gknd 12332 5 : : : cord-010119-t1x9gknd 12333 1 Correlation correlation NN cord-010119-t1x9gknd 12333 2 testing testing NN cord-010119-t1x9gknd 12333 3 of of IN cord-010119-t1x9gknd 12333 4 the the DT cord-010119-t1x9gknd 12333 5 ErytraV ErytraV NNS cord-010119-t1x9gknd 12333 6 R r NN cord-010119-t1x9gknd 12333 7 results result NNS cord-010119-t1x9gknd 12333 8 with with IN cord-010119-t1x9gknd 12333 9 the the DT cord-010119-t1x9gknd 12333 10 manual manual JJ cord-010119-t1x9gknd 12333 11 tube tube NN cord-010119-t1x9gknd 12333 12 testing testing NN cord-010119-t1x9gknd 12333 13 ( ( -LRB- cord-010119-t1x9gknd 12333 14 PEG PEG NNP cord-010119-t1x9gknd 12333 15 IAT IAT NNP cord-010119-t1x9gknd 12333 16 ; ; : cord-010119-t1x9gknd 12333 17 reference reference NN cord-010119-t1x9gknd 12333 18 method method NN cord-010119-t1x9gknd 12333 19 ) ) -RRB- cord-010119-t1x9gknd 12333 20 was be VBD cord-010119-t1x9gknd 12333 21 performed perform VBN cord-010119-t1x9gknd 12333 22 on on IN cord-010119-t1x9gknd 12333 23 100 100 CD cord-010119-t1x9gknd 12333 24 patient patient NN cord-010119-t1x9gknd 12333 25 samples sample NNS cord-010119-t1x9gknd 12333 26 for for IN cord-010119-t1x9gknd 12333 27 ABO ABO NNP cord-010119-t1x9gknd 12333 28 / / SYM cord-010119-t1x9gknd 12333 29 D d NN cord-010119-t1x9gknd 12333 30 typing typing NN cord-010119-t1x9gknd 12333 31 and and CC cord-010119-t1x9gknd 12333 32 antibody antibody NN cord-010119-t1x9gknd 12333 33 screening screening NN cord-010119-t1x9gknd 12333 34 ; ; : cord-010119-t1x9gknd 12333 35 of of IN cord-010119-t1x9gknd 12333 36 which which WDT cord-010119-t1x9gknd 12333 37 at at IN cord-010119-t1x9gknd 12333 38 least least JJS cord-010119-t1x9gknd 12333 39 10 10 CD cord-010119-t1x9gknd 12333 40 had have VBD cord-010119-t1x9gknd 12333 41 a a DT cord-010119-t1x9gknd 12333 42 positive positive JJ cord-010119-t1x9gknd 12333 43 antibody antibody NN cord-010119-t1x9gknd 12333 44 screen screen NN cord-010119-t1x9gknd 12333 45 . . . cord-010119-t1x9gknd 12334 1 Out out IN cord-010119-t1x9gknd 12334 2 of of IN cord-010119-t1x9gknd 12334 3 the the DT cord-010119-t1x9gknd 12334 4 10 10 CD cord-010119-t1x9gknd 12334 5 , , , cord-010119-t1x9gknd 12334 6 5 5 CD cord-010119-t1x9gknd 12334 7 had have VBD cord-010119-t1x9gknd 12334 8 known know VBN cord-010119-t1x9gknd 12334 9 antibody antibody NN cord-010119-t1x9gknd 12334 10 specificities specificity NNS cord-010119-t1x9gknd 12334 11 . . . cord-010119-t1x9gknd 12335 1 Forty forty CD cord-010119-t1x9gknd 12335 2 - - HYPH cord-010119-t1x9gknd 12335 3 two two CD cord-010119-t1x9gknd 12335 4 RBC RBC NNP cord-010119-t1x9gknd 12335 5 units unit NNS cord-010119-t1x9gknd 12335 6 were be VBD cord-010119-t1x9gknd 12335 7 also also RB cord-010119-t1x9gknd 12335 8 tested test VBN cord-010119-t1x9gknd 12335 9 for for IN cord-010119-t1x9gknd 12335 10 ABO ABO NNP cord-010119-t1x9gknd 12335 11 / / SYM cord-010119-t1x9gknd 12335 12 D D NNP cord-010119-t1x9gknd 12335 13 confirmation confirmation NN cord-010119-t1x9gknd 12335 14 ; ; : cord-010119-t1x9gknd 12335 15 of of IN cord-010119-t1x9gknd 12335 16 which which WDT cord-010119-t1x9gknd 12335 17 17 17 CD cord-010119-t1x9gknd 12335 18 were be VBD cord-010119-t1x9gknd 12335 19 D(- D(- NNP cord-010119-t1x9gknd 12335 20 ) ) -RRB- cord-010119-t1x9gknd 12335 21 and and CC cord-010119-t1x9gknd 12335 22 25 25 CD cord-010119-t1x9gknd 12335 23 were be VBD cord-010119-t1x9gknd 12335 24 D(1 D(1 NNP cord-010119-t1x9gknd 12335 25 ) ) -RRB- cord-010119-t1x9gknd 12335 26 . . . cord-010119-t1x9gknd 12336 1 Calculations calculation NNS cord-010119-t1x9gknd 12336 2 of of IN cord-010119-t1x9gknd 12336 3 concordance concordance NN cord-010119-t1x9gknd 12336 4 , , , cord-010119-t1x9gknd 12336 5 sensitivity sensitivity NN cord-010119-t1x9gknd 12336 6 , , , cord-010119-t1x9gknd 12336 7 and and CC cord-010119-t1x9gknd 12336 8 specificity specificity NN cord-010119-t1x9gknd 12336 9 were be VBD cord-010119-t1x9gknd 12336 10 performed perform VBN cord-010119-t1x9gknd 12336 11 . . . cord-010119-t1x9gknd 12337 1 Precision precision NN cord-010119-t1x9gknd 12337 2 studies study NNS cord-010119-t1x9gknd 12337 3 were be VBD cord-010119-t1x9gknd 12337 4 also also RB cord-010119-t1x9gknd 12337 5 done do VBN cord-010119-t1x9gknd 12337 6 . . . cord-010119-t1x9gknd 12338 1 Interface interface NN cord-010119-t1x9gknd 12338 2 testing testing NN cord-010119-t1x9gknd 12338 3 of of IN cord-010119-t1x9gknd 12338 4 ErytraV ErytraV NNS cord-010119-t1x9gknd 12338 5 R r NN cord-010119-t1x9gknd 12338 6 , , , cord-010119-t1x9gknd 12338 7 HCLL HCLL NNP cord-010119-t1x9gknd 12338 8 and and CC cord-010119-t1x9gknd 12338 9 the the DT cord-010119-t1x9gknd 12338 10 hospital hospital NN cord-010119-t1x9gknd 12338 11 's 's POS cord-010119-t1x9gknd 12338 12 information information NN cord-010119-t1x9gknd 12338 13 system system NN cord-010119-t1x9gknd 12338 14 using use VBG cord-010119-t1x9gknd 12338 15 the the DT cord-010119-t1x9gknd 12338 16 Maestro Maestro NNP cord-010119-t1x9gknd 12338 17 TM TM NNP cord-010119-t1x9gknd 12338 18 interface interface NN cord-010119-t1x9gknd 12338 19 system system NN cord-010119-t1x9gknd 12338 20 was be VBD cord-010119-t1x9gknd 12338 21 performed perform VBN cord-010119-t1x9gknd 12338 22 and and CC cord-010119-t1x9gknd 12338 23 validated validate VBN cord-010119-t1x9gknd 12338 24 . . . cord-010119-t1x9gknd 12339 1 Results result NNS cord-010119-t1x9gknd 12339 2 / / SYM cord-010119-t1x9gknd 12339 3 Finding finding NN cord-010119-t1x9gknd 12339 4 : : : cord-010119-t1x9gknd 12340 1 Concordant concordant JJ cord-010119-t1x9gknd 12340 2 results result NNS cord-010119-t1x9gknd 12340 3 between between IN cord-010119-t1x9gknd 12340 4 both both DT cord-010119-t1x9gknd 12340 5 methods method NNS cord-010119-t1x9gknd 12340 6 were be VBD cord-010119-t1x9gknd 12340 7 obtained obtain VBN cord-010119-t1x9gknd 12340 8 in in IN cord-010119-t1x9gknd 12340 9 all all DT cord-010119-t1x9gknd 12340 10 of of IN cord-010119-t1x9gknd 12340 11 the the DT cord-010119-t1x9gknd 12340 12 100 100 CD cord-010119-t1x9gknd 12340 13 patient patient NN cord-010119-t1x9gknd 12340 14 and and CC cord-010119-t1x9gknd 12340 15 42 42 CD cord-010119-t1x9gknd 12340 16 donor donor NN cord-010119-t1x9gknd 12340 17 samples sample NNS cord-010119-t1x9gknd 12340 18 tested test VBN cord-010119-t1x9gknd 12340 19 ( ( -LRB- cord-010119-t1x9gknd 12340 20 100 100 CD cord-010119-t1x9gknd 12340 21 % % NN cord-010119-t1x9gknd 12340 22 concordance concordance NN cord-010119-t1x9gknd 12340 23 ) ) -RRB- cord-010119-t1x9gknd 12340 24 . . . cord-010119-t1x9gknd 12341 1 All all DT cord-010119-t1x9gknd 12341 2 10 10 CD cord-010119-t1x9gknd 12341 3 samples sample NNS cord-010119-t1x9gknd 12341 4 with with IN cord-010119-t1x9gknd 12341 5 positive positive JJ cord-010119-t1x9gknd 12341 6 antibody antibody NN cord-010119-t1x9gknd 12341 7 screens screen NNS cord-010119-t1x9gknd 12341 8 were be VBD cord-010119-t1x9gknd 12341 9 obtained obtain VBN cord-010119-t1x9gknd 12341 10 by by IN cord-010119-t1x9gknd 12341 11 both both DT cord-010119-t1x9gknd 12341 12 methods method NNS cord-010119-t1x9gknd 12341 13 . . . cord-010119-t1x9gknd 12342 1 All all DT cord-010119-t1x9gknd 12342 2 clinically clinically RB cord-010119-t1x9gknd 12342 3 significant significant JJ cord-010119-t1x9gknd 12342 4 antibodies antibody NNS cord-010119-t1x9gknd 12342 5 were be VBD cord-010119-t1x9gknd 12342 6 detected detect VBN cord-010119-t1x9gknd 12342 7 by by IN cord-010119-t1x9gknd 12342 8 both both DT cord-010119-t1x9gknd 12342 9 systems system NNS cord-010119-t1x9gknd 12342 10 . . . cord-010119-t1x9gknd 12343 1 ErytraV ErytraV NNS cord-010119-t1x9gknd 12343 2 R R NNP cord-010119-t1x9gknd 12343 3 gave give VBD cord-010119-t1x9gknd 12343 4 100 100 CD cord-010119-t1x9gknd 12343 5 % % NN cord-010119-t1x9gknd 12343 6 sensitivity sensitivity NN cord-010119-t1x9gknd 12343 7 and and CC cord-010119-t1x9gknd 12343 8 specificity specificity NN cord-010119-t1x9gknd 12343 9 . . . cord-010119-t1x9gknd 12344 1 The the DT cord-010119-t1x9gknd 12344 2 precision precision NN cord-010119-t1x9gknd 12344 3 studies study NNS cord-010119-t1x9gknd 12344 4 showed show VBD cord-010119-t1x9gknd 12344 5 that that IN cord-010119-t1x9gknd 12344 6 both both DT cord-010119-t1x9gknd 12344 7 methods method NNS cord-010119-t1x9gknd 12344 8 gave give VBD cord-010119-t1x9gknd 12344 9 the the DT cord-010119-t1x9gknd 12344 10 same same JJ cord-010119-t1x9gknd 12344 11 type type NN cord-010119-t1x9gknd 12344 12 and and CC cord-010119-t1x9gknd 12344 13 screen screen NN cord-010119-t1x9gknd 12344 14 results result NNS cord-010119-t1x9gknd 12344 15 for for IN cord-010119-t1x9gknd 12344 16 5 5 CD cord-010119-t1x9gknd 12344 17 samples sample NNS cord-010119-t1x9gknd 12344 18 at at IN cord-010119-t1x9gknd 12344 19 3 3 CD cord-010119-t1x9gknd 12344 20 different different JJ cord-010119-t1x9gknd 12344 21 testing testing NN cord-010119-t1x9gknd 12344 22 events event NNS cord-010119-t1x9gknd 12344 23 . . . cord-010119-t1x9gknd 12345 1 After after IN cord-010119-t1x9gknd 12345 2 validation validation NN cord-010119-t1x9gknd 12345 3 of of IN cord-010119-t1x9gknd 12345 4 the the DT cord-010119-t1x9gknd 12345 5 LIS LIS NNP cord-010119-t1x9gknd 12345 6 upgrade upgrade NN cord-010119-t1x9gknd 12345 7 and and CC cord-010119-t1x9gknd 12345 8 interface interface NN cord-010119-t1x9gknd 12345 9 system system NN cord-010119-t1x9gknd 12345 10 change change NN cord-010119-t1x9gknd 12345 11 , , , cord-010119-t1x9gknd 12345 12 a a DT cord-010119-t1x9gknd 12345 13 bidirectional bidirectional JJ cord-010119-t1x9gknd 12345 14 interface interface NN cord-010119-t1x9gknd 12345 15 with with IN cord-010119-t1x9gknd 12345 16 HCLL HCLL NNP cord-010119-t1x9gknd 12345 17 TM TM NNP cord-010119-t1x9gknd 12345 18 was be VBD cord-010119-t1x9gknd 12345 19 established establish VBN cord-010119-t1x9gknd 12345 20 . . . cord-010119-t1x9gknd 12346 1 The the DT cord-010119-t1x9gknd 12346 2 instrument instrument NN cord-010119-t1x9gknd 12346 3 has have VBZ cord-010119-t1x9gknd 12346 4 been be VBN cord-010119-t1x9gknd 12346 5 operational operational JJ cord-010119-t1x9gknd 12346 6 in in IN cord-010119-t1x9gknd 12346 7 our -PRON- PRP$ cord-010119-t1x9gknd 12346 8 lab lab NN cord-010119-t1x9gknd 12346 9 for for IN cord-010119-t1x9gknd 12346 10 over over IN cord-010119-t1x9gknd 12346 11 3 3 CD cord-010119-t1x9gknd 12346 12 months month NNS cord-010119-t1x9gknd 12346 13 . . . cord-010119-t1x9gknd 12347 1 Conclusion conclusion NN cord-010119-t1x9gknd 12347 2 : : : cord-010119-t1x9gknd 12347 3 ErytraV ErytraV NNS cord-010119-t1x9gknd 12347 4 R r NN cord-010119-t1x9gknd 12347 5 was be VBD cord-010119-t1x9gknd 12347 6 found find VBN cord-010119-t1x9gknd 12347 7 to to TO cord-010119-t1x9gknd 12347 8 be be VB cord-010119-t1x9gknd 12347 9 reliable reliable JJ cord-010119-t1x9gknd 12347 10 and and CC cord-010119-t1x9gknd 12347 11 accurate accurate JJ cord-010119-t1x9gknd 12347 12 and and CC cord-010119-t1x9gknd 12347 13 can can MD cord-010119-t1x9gknd 12347 14 handle handle VB cord-010119-t1x9gknd 12347 15 the the DT cord-010119-t1x9gknd 12347 16 high high JJ cord-010119-t1x9gknd 12347 17 workload workload NN cord-010119-t1x9gknd 12347 18 of of IN cord-010119-t1x9gknd 12347 19 our -PRON- PRP$ cord-010119-t1x9gknd 12347 20 lab lab NN cord-010119-t1x9gknd 12347 21 . . . cord-010119-t1x9gknd 12348 1 Users user NNS cord-010119-t1x9gknd 12348 2 found find VBD cord-010119-t1x9gknd 12348 3 the the DT cord-010119-t1x9gknd 12348 4 instrument instrument NN cord-010119-t1x9gknd 12348 5 easy easy JJ cord-010119-t1x9gknd 12348 6 to to TO cord-010119-t1x9gknd 12348 7 use use VB cord-010119-t1x9gknd 12348 8 ; ; : cord-010119-t1x9gknd 12348 9 hence hence RB cord-010119-t1x9gknd 12348 10 training training NN cord-010119-t1x9gknd 12348 11 , , , cord-010119-t1x9gknd 12348 12 proficiency proficiency NN cord-010119-t1x9gknd 12348 13 , , , cord-010119-t1x9gknd 12348 14 and and CC cord-010119-t1x9gknd 12348 15 competency competency NN cord-010119-t1x9gknd 12348 16 of of IN cord-010119-t1x9gknd 12348 17 the the DT cord-010119-t1x9gknd 12348 18 users user NNS cord-010119-t1x9gknd 12348 19 are be VBP cord-010119-t1x9gknd 12348 20 achievable achievable JJ cord-010119-t1x9gknd 12348 21 and and CC cord-010119-t1x9gknd 12348 22 manageable manageable JJ cord-010119-t1x9gknd 12348 23 . . . cord-010119-t1x9gknd 12349 1 The the DT cord-010119-t1x9gknd 12349 2 validation validation NN cord-010119-t1x9gknd 12349 3 of of IN cord-010119-t1x9gknd 12349 4 the the DT cord-010119-t1x9gknd 12349 5 the the DT cord-010119-t1x9gknd 12349 6 instrument instrument NN cord-010119-t1x9gknd 12349 7 is be VBZ cord-010119-t1x9gknd 12349 8 straightforward straightforward JJ cord-010119-t1x9gknd 12349 9 . . . cord-010119-t1x9gknd 12350 1 The the DT cord-010119-t1x9gknd 12350 2 major major JJ cord-010119-t1x9gknd 12350 3 challenge challenge NN cord-010119-t1x9gknd 12350 4 and and CC cord-010119-t1x9gknd 12350 5 delay delay NN cord-010119-t1x9gknd 12350 6 in in IN cord-010119-t1x9gknd 12350 7 the the DT cord-010119-t1x9gknd 12350 8 implementation implementation NN cord-010119-t1x9gknd 12350 9 experienced experience VBN cord-010119-t1x9gknd 12350 10 by by IN cord-010119-t1x9gknd 12350 11 this this DT cord-010119-t1x9gknd 12350 12 blood blood NN cord-010119-t1x9gknd 12350 13 bank bank NN cord-010119-t1x9gknd 12350 14 were be VBD cord-010119-t1x9gknd 12350 15 attributed attribute VBN cord-010119-t1x9gknd 12350 16 to to IN cord-010119-t1x9gknd 12350 17 the the DT cord-010119-t1x9gknd 12350 18 concurrently concurrently RB cord-010119-t1x9gknd 12350 19 occurring occur VBG cord-010119-t1x9gknd 12350 20 LIS LIS NNP cord-010119-t1x9gknd 12350 21 upgrade upgrade NN cord-010119-t1x9gknd 12350 22 and and CC cord-010119-t1x9gknd 12350 23 migration migration NN cord-010119-t1x9gknd 12350 24 of of IN cord-010119-t1x9gknd 12350 25 the the DT cord-010119-t1x9gknd 12350 26 data data NN cord-010119-t1x9gknd 12350 27 integration integration NN cord-010119-t1x9gknd 12350 28 system system NN cord-010119-t1x9gknd 12350 29 . . . cord-010119-t1x9gknd 12351 1 A a DT cord-010119-t1x9gknd 12351 2 post post JJ cord-010119-t1x9gknd 12351 3 - - JJ cord-010119-t1x9gknd 12351 4 implementation implementation JJ cord-010119-t1x9gknd 12351 5 workflow workflow NN cord-010119-t1x9gknd 12351 6 assessment assessment NN cord-010119-t1x9gknd 12351 7 would would MD cord-010119-t1x9gknd 12351 8 be be VB cord-010119-t1x9gknd 12351 9 ideal ideal JJ cord-010119-t1x9gknd 12351 10 to to TO cord-010119-t1x9gknd 12351 11 perform perform VB cord-010119-t1x9gknd 12351 12 to to TO cord-010119-t1x9gknd 12351 13 ensure ensure VB cord-010119-t1x9gknd 12351 14 that that IN cord-010119-t1x9gknd 12351 15 the the DT cord-010119-t1x9gknd 12351 16 instrument instrument NN cord-010119-t1x9gknd 12351 17 is be VBZ cord-010119-t1x9gknd 12351 18 being be VBG cord-010119-t1x9gknd 12351 19 used use VBN cord-010119-t1x9gknd 12351 20 at at IN cord-010119-t1x9gknd 12351 21 its -PRON- PRP$ cord-010119-t1x9gknd 12351 22 full full JJ cord-010119-t1x9gknd 12351 23 potential potential NN cord-010119-t1x9gknd 12351 24 . . . cord-010119-t1x9gknd 12352 1 Implementation implementation NN cord-010119-t1x9gknd 12352 2 of of IN cord-010119-t1x9gknd 12352 3 a a DT cord-010119-t1x9gknd 12352 4 System System NNP cord-010119-t1x9gknd 12352 5 - - : cord-010119-t1x9gknd 12352 6 Wide Wide NNP cord-010119-t1x9gknd 12352 7 Platelet platelet NN cord-010119-t1x9gknd 12352 8 Inventory inventory NN cord-010119-t1x9gknd 12352 9 Report report NN cord-010119-t1x9gknd 12352 10 Optimizes optimize VBZ cord-010119-t1x9gknd 12352 11 Platelet platelet NN cord-010119-t1x9gknd 12352 12 Utilization utilization NN cord-010119-t1x9gknd 12352 13 and and CC cord-010119-t1x9gknd 12352 14 Reduces reduce VBZ cord-010119-t1x9gknd 12353 1 Unit unit NN cord-010119-t1x9gknd 12353 2 Wastage wastage NN cord-010119-t1x9gknd 12353 3 Elly Elly NNP cord-010119-t1x9gknd 12353 4 Landolfi Landolfi NNP cord-010119-t1x9gknd 12354 1 * * NFP cord-010119-t1x9gknd 12354 2 1 1 CD cord-010119-t1x9gknd 12354 3 , , , cord-010119-t1x9gknd 12354 4 Craig Craig NNP cord-010119-t1x9gknd 12354 5 Fletcher Fletcher NNP cord-010119-t1x9gknd 12354 6 2 2 CD cord-010119-t1x9gknd 12354 7 and and CC cord-010119-t1x9gknd 12354 8 Peter Peter NNP cord-010119-t1x9gknd 12354 9 Millward Millward NNP cord-010119-t1x9gknd 12354 10 1 1 CD cord-010119-t1x9gknd 12354 11 . . . cord-010119-t1x9gknd 12355 1 1 1 CD cord-010119-t1x9gknd 12355 2 Beaumont Beaumont NNP cord-010119-t1x9gknd 12355 3 Hospital Hospital NNP cord-010119-t1x9gknd 12355 4 , , , cord-010119-t1x9gknd 12355 5 2 2 CD cord-010119-t1x9gknd 12355 6 Beaumont Beaumont NNP cord-010119-t1x9gknd 12355 7 Health Health NNP cord-010119-t1x9gknd 12355 8 System System NNP cord-010119-t1x9gknd 12355 9 Background Background NNP cord-010119-t1x9gknd 12355 10 / / SYM cord-010119-t1x9gknd 12355 11 Case Case NNP cord-010119-t1x9gknd 12355 12 Studies Studies NNPS cord-010119-t1x9gknd 12355 13 : : : cord-010119-t1x9gknd 12355 14 A a DT cord-010119-t1x9gknd 12355 15 sufficient sufficient JJ cord-010119-t1x9gknd 12355 16 number number NN cord-010119-t1x9gknd 12355 17 of of IN cord-010119-t1x9gknd 12355 18 blood blood NN cord-010119-t1x9gknd 12355 19 components component NNS cord-010119-t1x9gknd 12355 20 should should MD cord-010119-t1x9gknd 12355 21 be be VB cord-010119-t1x9gknd 12355 22 available available JJ cord-010119-t1x9gknd 12355 23 to to TO cord-010119-t1x9gknd 12355 24 meet meet VB cord-010119-t1x9gknd 12355 25 routine routine JJ cord-010119-t1x9gknd 12355 26 and and CC cord-010119-t1x9gknd 12355 27 emergent emergent JJ cord-010119-t1x9gknd 12355 28 hospital hospital NN cord-010119-t1x9gknd 12355 29 needs need NNS cord-010119-t1x9gknd 12355 30 . . . cord-010119-t1x9gknd 12356 1 This this DT cord-010119-t1x9gknd 12356 2 must must MD cord-010119-t1x9gknd 12356 3 be be VB cord-010119-t1x9gknd 12356 4 assured assure VBN cord-010119-t1x9gknd 12356 5 while while IN cord-010119-t1x9gknd 12356 6 minimizing minimize VBG cord-010119-t1x9gknd 12356 7 outdating outdate VBG cord-010119-t1x9gknd 12356 8 of of IN cord-010119-t1x9gknd 12356 9 scarce scarce JJ cord-010119-t1x9gknd 12356 10 and and CC cord-010119-t1x9gknd 12356 11 expensive expensive JJ cord-010119-t1x9gknd 12356 12 blood blood NN cord-010119-t1x9gknd 12356 13 components component NNS cord-010119-t1x9gknd 12356 14 -an -an : cord-010119-t1x9gknd 12356 15 inherent inherent JJ cord-010119-t1x9gknd 12356 16 challenge challenge NN cord-010119-t1x9gknd 12356 17 with with IN cord-010119-t1x9gknd 12356 18 platelet platelet NN cord-010119-t1x9gknd 12356 19 units unit NNS cord-010119-t1x9gknd 12356 20 which which WDT cord-010119-t1x9gknd 12356 21 have have VBP cord-010119-t1x9gknd 12356 22 a a DT cord-010119-t1x9gknd 12356 23 short short JJ cord-010119-t1x9gknd 12356 24 5-day 5-day JJ cord-010119-t1x9gknd 12356 25 shelf shelf NN cord-010119-t1x9gknd 12356 26 - - HYPH cord-010119-t1x9gknd 12356 27 life life NN cord-010119-t1x9gknd 12356 28 . . . cord-010119-t1x9gknd 12357 1 We -PRON- PRP cord-010119-t1x9gknd 12357 2 report report VBP cord-010119-t1x9gknd 12357 3 the the DT cord-010119-t1x9gknd 12357 4 results result NNS cord-010119-t1x9gknd 12357 5 of of IN cord-010119-t1x9gknd 12357 6 a a DT cord-010119-t1x9gknd 12357 7 quality quality NN cord-010119-t1x9gknd 12357 8 improvement improvement NN cord-010119-t1x9gknd 12357 9 project project NN cord-010119-t1x9gknd 12357 10 implementing implement VBG cord-010119-t1x9gknd 12357 11 a a DT cord-010119-t1x9gknd 12357 12 custom custom NN cord-010119-t1x9gknd 12357 13 computerized computerized NN cord-010119-t1x9gknd 12357 14 Platelet Platelet NNP cord-010119-t1x9gknd 12357 15 Inventory Inventory NNP cord-010119-t1x9gknd 12357 16 Report Report NNP cord-010119-t1x9gknd 12357 17 designed design VBN cord-010119-t1x9gknd 12357 18 to to TO cord-010119-t1x9gknd 12357 19 mitigate mitigate VB cord-010119-t1x9gknd 12357 20 the the DT cord-010119-t1x9gknd 12357 21 most most RBS cord-010119-t1x9gknd 12357 22 common common JJ cord-010119-t1x9gknd 12357 23 cause cause NN cord-010119-t1x9gknd 12357 24 for for IN cord-010119-t1x9gknd 12357 25 platelet platelet NN cord-010119-t1x9gknd 12357 26 wastage wastage NN cord-010119-t1x9gknd 12357 27 at at IN cord-010119-t1x9gknd 12357 28 our -PRON- PRP$ cord-010119-t1x9gknd 12357 29 institution institution NN cord-010119-t1x9gknd 12357 30 : : : cord-010119-t1x9gknd 12357 31 high high JJ cord-010119-t1x9gknd 12357 32 platelet platelet NN cord-010119-t1x9gknd 12357 33 outdate outdate JJ cord-010119-t1x9gknd 12357 34 rates rate NNS cord-010119-t1x9gknd 12357 35 . . . cord-010119-t1x9gknd 12358 1 The the DT cord-010119-t1x9gknd 12358 2 report report NN cord-010119-t1x9gknd 12358 3 includes include VBZ cord-010119-t1x9gknd 12358 4 blood blood NN cord-010119-t1x9gknd 12358 5 type type NN cord-010119-t1x9gknd 12358 6 , , , cord-010119-t1x9gknd 12358 7 product product NN cord-010119-t1x9gknd 12358 8 code code NN cord-010119-t1x9gknd 12358 9 , , , cord-010119-t1x9gknd 12358 10 unit unit NN cord-010119-t1x9gknd 12358 11 number number NN cord-010119-t1x9gknd 12358 12 , , , cord-010119-t1x9gknd 12358 13 respective respective JJ cord-010119-t1x9gknd 12358 14 product product NN cord-010119-t1x9gknd 12358 15 attributes attribute NNS cord-010119-t1x9gknd 12358 16 , , , cord-010119-t1x9gknd 12358 17 supplier supplier NN cord-010119-t1x9gknd 12358 18 and and CC cord-010119-t1x9gknd 12358 19 availability availability NN cord-010119-t1x9gknd 12358 20 status status NN cord-010119-t1x9gknd 12358 21 of of IN cord-010119-t1x9gknd 12358 22 all all DT cord-010119-t1x9gknd 12358 23 platelet platelet NN cord-010119-t1x9gknd 12358 24 units unit NNS cord-010119-t1x9gknd 12358 25 for for IN cord-010119-t1x9gknd 12358 26 each each DT cord-010119-t1x9gknd 12358 27 hospital hospital NN cord-010119-t1x9gknd 12358 28 location location NN cord-010119-t1x9gknd 12358 29 . . . cord-010119-t1x9gknd 12359 1 All all DT cord-010119-t1x9gknd 12359 2 system system NN cord-010119-t1x9gknd 12359 3 blood blood NN cord-010119-t1x9gknd 12359 4 banks bank NNS cord-010119-t1x9gknd 12359 5 receive receive VBP cord-010119-t1x9gknd 12359 6 a a DT cord-010119-t1x9gknd 12359 7 morning morning NN cord-010119-t1x9gknd 12359 8 fax fax NN cord-010119-t1x9gknd 12359 9 of of IN cord-010119-t1x9gknd 12359 10 the the DT cord-010119-t1x9gknd 12359 11 report report NN cord-010119-t1x9gknd 12359 12 which which WDT cord-010119-t1x9gknd 12359 13 facilitates facilitate VBZ cord-010119-t1x9gknd 12359 14 transfer transfer NN cord-010119-t1x9gknd 12359 15 of of IN cord-010119-t1x9gknd 12359 16 units unit NNS cord-010119-t1x9gknd 12359 17 prior prior RB cord-010119-t1x9gknd 12359 18 to to IN cord-010119-t1x9gknd 12359 19 expiration expiration NN cord-010119-t1x9gknd 12359 20 and and CC cord-010119-t1x9gknd 12359 21 adjustments adjustment NNS cord-010119-t1x9gknd 12359 22 are be VBP cord-010119-t1x9gknd 12359 23 more more RBR cord-010119-t1x9gknd 12359 24 readily readily RB cord-010119-t1x9gknd 12359 25 made make VBN cord-010119-t1x9gknd 12359 26 for for IN cord-010119-t1x9gknd 12359 27 product product NN cord-010119-t1x9gknd 12359 28 orders order NNS cord-010119-t1x9gknd 12359 29 to to IN cord-010119-t1x9gknd 12359 30 the the DT cord-010119-t1x9gknd 12359 31 supplier supplier NN cord-010119-t1x9gknd 12359 32 . . . cord-010119-t1x9gknd 12360 1 Study Study NNP cord-010119-t1x9gknd 12360 2 Design Design NNP cord-010119-t1x9gknd 12360 3 / / SYM cord-010119-t1x9gknd 12360 4 Method method NN cord-010119-t1x9gknd 12360 5 : : : cord-010119-t1x9gknd 12360 6 The the DT cord-010119-t1x9gknd 12360 7 study study NN cord-010119-t1x9gknd 12360 8 was be VBD cord-010119-t1x9gknd 12360 9 conducted conduct VBN cord-010119-t1x9gknd 12360 10 in in IN cord-010119-t1x9gknd 12360 11 the the DT cord-010119-t1x9gknd 12360 12 hospital hospital NN cord-010119-t1x9gknd 12360 13 - - HYPH cord-010119-t1x9gknd 12360 14 based base VBN cord-010119-t1x9gknd 12360 15 blood blood NN cord-010119-t1x9gknd 12360 16 bank bank NN cord-010119-t1x9gknd 12360 17 and and CC cord-010119-t1x9gknd 12360 18 based base VBN cord-010119-t1x9gknd 12360 19 on on IN cord-010119-t1x9gknd 12360 20 available available JJ cord-010119-t1x9gknd 12360 21 platelet platelet NN cord-010119-t1x9gknd 12360 22 inventory inventory NN cord-010119-t1x9gknd 12360 23 and and CC cord-010119-t1x9gknd 12360 24 wastage wastage NN cord-010119-t1x9gknd 12360 25 quality quality NN cord-010119-t1x9gknd 12360 26 data datum NNS cord-010119-t1x9gknd 12360 27 . . . cord-010119-t1x9gknd 12361 1 The the DT cord-010119-t1x9gknd 12361 2 report report NN cord-010119-t1x9gknd 12361 3 went go VBD cord-010119-t1x9gknd 12361 4 live live JJ cord-010119-t1x9gknd 12361 5 October October NNP cord-010119-t1x9gknd 12361 6 2014 2014 CD cord-010119-t1x9gknd 12361 7 and and CC cord-010119-t1x9gknd 12361 8 quality quality NN cord-010119-t1x9gknd 12361 9 data datum NNS cord-010119-t1x9gknd 12361 10 was be VBD cord-010119-t1x9gknd 12361 11 reviewed review VBN cord-010119-t1x9gknd 12361 12 from from IN cord-010119-t1x9gknd 12361 13 August August NNP cord-010119-t1x9gknd 12361 14 2013 2013 CD cord-010119-t1x9gknd 12361 15 to to IN cord-010119-t1x9gknd 12361 16 December December NNP cord-010119-t1x9gknd 12361 17 2016 2016 CD cord-010119-t1x9gknd 12361 18 . . . cord-010119-t1x9gknd 12362 1 The the DT cord-010119-t1x9gknd 12362 2 collected collect VBN cord-010119-t1x9gknd 12362 3 data datum NNS cord-010119-t1x9gknd 12362 4 was be VBD cord-010119-t1x9gknd 12362 5 then then RB cord-010119-t1x9gknd 12362 6 analyzed analyze VBN cord-010119-t1x9gknd 12362 7 using use VBG cord-010119-t1x9gknd 12362 8 descriptive descriptive JJ cord-010119-t1x9gknd 12362 9 statistical statistical JJ cord-010119-t1x9gknd 12362 10 methods method NNS cord-010119-t1x9gknd 12362 11 . . . cord-010119-t1x9gknd 12363 1 Results/ Results/ . cord-010119-t1x9gknd 12364 1 Finding finding NN cord-010119-t1x9gknd 12364 2 : : : cord-010119-t1x9gknd 12365 1 Data datum NNS cord-010119-t1x9gknd 12365 2 from from IN cord-010119-t1x9gknd 12365 3 2016 2016 CD cord-010119-t1x9gknd 12365 4 indicates indicate VBZ cord-010119-t1x9gknd 12365 5 platelet platelet NN cord-010119-t1x9gknd 12365 6 wastage wastage NN cord-010119-t1x9gknd 12365 7 comprised comprise VBN cord-010119-t1x9gknd 12365 8 1 1 CD cord-010119-t1x9gknd 12365 9 % % NN cord-010119-t1x9gknd 12365 10 of of IN cord-010119-t1x9gknd 12365 11 total total JJ cord-010119-t1x9gknd 12365 12 received receive VBN cord-010119-t1x9gknd 12365 13 platelets platelet NNS cord-010119-t1x9gknd 12365 14 and and CC cord-010119-t1x9gknd 12365 15 79 79 CD cord-010119-t1x9gknd 12365 16 % % NN cord-010119-t1x9gknd 12365 17 of of IN cord-010119-t1x9gknd 12365 18 these these DT cord-010119-t1x9gknd 12365 19 wasted waste VBN cord-010119-t1x9gknd 12365 20 platelet platelet NN cord-010119-t1x9gknd 12365 21 units unit NNS cord-010119-t1x9gknd 12365 22 were be VBD cord-010119-t1x9gknd 12365 23 due due JJ cord-010119-t1x9gknd 12365 24 to to IN cord-010119-t1x9gknd 12365 25 expiration expiration NN cord-010119-t1x9gknd 12365 26 . . . cord-010119-t1x9gknd 12366 1 Other other JJ cord-010119-t1x9gknd 12366 2 reasons reason NNS cord-010119-t1x9gknd 12366 3 included include VBD cord-010119-t1x9gknd 12366 4 failed fail VBN cord-010119-t1x9gknd 12366 5 visual visual JJ cord-010119-t1x9gknd 12366 6 inspection inspection NN cord-010119-t1x9gknd 12366 7 , , , cord-010119-t1x9gknd 12366 8 blood blood NN cord-010119-t1x9gknd 12366 9 dispensed dispense VBN cord-010119-t1x9gknd 12366 10 but but CC cord-010119-t1x9gknd 12366 11 not not RB cord-010119-t1x9gknd 12366 12 used use VBN cord-010119-t1x9gknd 12366 13 and and CC cord-010119-t1x9gknd 12366 14 wasted waste VBN cord-010119-t1x9gknd 12366 15 on on IN cord-010119-t1x9gknd 12366 16 the the DT cord-010119-t1x9gknd 12366 17 floors floor NNS cord-010119-t1x9gknd 12366 18 , , , cord-010119-t1x9gknd 12366 19 potential potential JJ cord-010119-t1x9gknd 12366 20 tube tube NN cord-010119-t1x9gknd 12366 21 station station NN cord-010119-t1x9gknd 12366 22 problems problem NNS cord-010119-t1x9gknd 12366 23 or or CC cord-010119-t1x9gknd 12366 24 short short RB cord-010119-t1x9gknd 12366 25 - - HYPH cord-010119-t1x9gknd 12366 26 dated date VBN cord-010119-t1x9gknd 12366 27 units unit NNS cord-010119-t1x9gknd 12366 28 transferred transfer VBN cord-010119-t1x9gknd 12366 29 into into IN cord-010119-t1x9gknd 12366 30 our -PRON- PRP$ cord-010119-t1x9gknd 12366 31 blood blood NN cord-010119-t1x9gknd 12366 32 bank bank NN cord-010119-t1x9gknd 12366 33 from from IN cord-010119-t1x9gknd 12366 34 another another DT cord-010119-t1x9gknd 12366 35 facility facility NN cord-010119-t1x9gknd 12366 36 . . . cord-010119-t1x9gknd 12367 1 The the DT cord-010119-t1x9gknd 12367 2 mean mean NN cord-010119-t1x9gknd 12367 3 of of IN cord-010119-t1x9gknd 12367 4 monthly monthly JJ cord-010119-t1x9gknd 12367 5 wasted waste VBN cord-010119-t1x9gknd 12367 6 platelet platelet NN cord-010119-t1x9gknd 12367 7 units unit NNS cord-010119-t1x9gknd 12367 8 12 12 CD cord-010119-t1x9gknd 12367 9 months month NNS cord-010119-t1x9gknd 12367 10 preimplementation preimplementation NN cord-010119-t1x9gknd 12367 11 of of IN cord-010119-t1x9gknd 12367 12 the the DT cord-010119-t1x9gknd 12367 13 report report NN cord-010119-t1x9gknd 12367 14 was be VBD cord-010119-t1x9gknd 12367 15 13 13 CD cord-010119-t1x9gknd 12367 16 units unit NNS cord-010119-t1x9gknd 12367 17 , , , cord-010119-t1x9gknd 12367 18 compared compare VBN cord-010119-t1x9gknd 12367 19 to to IN cord-010119-t1x9gknd 12367 20 11 11 CD cord-010119-t1x9gknd 12367 21 units unit NNS cord-010119-t1x9gknd 12367 22 12 12 CD cord-010119-t1x9gknd 12367 23 months month NNS cord-010119-t1x9gknd 12367 24 post post NN cord-010119-t1x9gknd 12367 25 - - NN cord-010119-t1x9gknd 12367 26 implementation implementation NN cord-010119-t1x9gknd 12367 27 and and CC cord-010119-t1x9gknd 12367 28 5 5 CD cord-010119-t1x9gknd 12367 29 units unit NNS cord-010119-t1x9gknd 12367 30 24 24 CD cord-010119-t1x9gknd 12367 31 months month NNS cord-010119-t1x9gknd 12367 32 post post NN cord-010119-t1x9gknd 12367 33 - - NN cord-010119-t1x9gknd 12367 34 implementation implementation NN cord-010119-t1x9gknd 12367 35 . . . cord-010119-t1x9gknd 12368 1 Wastage wastage NN cord-010119-t1x9gknd 12368 2 rates rate NNS cord-010119-t1x9gknd 12368 3 improved improve VBD cord-010119-t1x9gknd 12368 4 from from IN cord-010119-t1x9gknd 12368 5 6 6 CD cord-010119-t1x9gknd 12368 6 % % NN cord-010119-t1x9gknd 12368 7 ( ( -LRB- cord-010119-t1x9gknd 12368 8 wasted waste VBN cord-010119-t1x9gknd 12368 9 yearly yearly JJ cord-010119-t1x9gknd 12368 10 platelets platelet NNS cord-010119-t1x9gknd 12368 11 / / SYM cord-010119-t1x9gknd 12368 12 total total NN cord-010119-t1x9gknd 12368 13 received receive VBN cord-010119-t1x9gknd 12368 14 yearly yearly JJ cord-010119-t1x9gknd 12368 15 platelet platelet NN cord-010119-t1x9gknd 12368 16 units unit NNS cord-010119-t1x9gknd 12368 17 ) ) -RRB- cord-010119-t1x9gknd 12368 18 in in IN cord-010119-t1x9gknd 12368 19 2014 2014 CD cord-010119-t1x9gknd 12368 20 , , , cord-010119-t1x9gknd 12368 21 the the DT cord-010119-t1x9gknd 12368 22 year year NN cord-010119-t1x9gknd 12368 23 of of IN cord-010119-t1x9gknd 12368 24 report report NN cord-010119-t1x9gknd 12368 25 implementation implementation NN cord-010119-t1x9gknd 12368 26 , , , cord-010119-t1x9gknd 12368 27 to to TO cord-010119-t1x9gknd 12368 28 post post VB cord-010119-t1x9gknd 12368 29 - - JJ cord-010119-t1x9gknd 12368 30 implementation implementation JJ cord-010119-t1x9gknd 12368 31 rates rate NNS cord-010119-t1x9gknd 12368 32 of of IN cord-010119-t1x9gknd 12368 33 3 3 CD cord-010119-t1x9gknd 12368 34 % % NN cord-010119-t1x9gknd 12368 35 in in IN cord-010119-t1x9gknd 12368 36 2015 2015 CD cord-010119-t1x9gknd 12368 37 and and CC cord-010119-t1x9gknd 12368 38 1 1 CD cord-010119-t1x9gknd 12368 39 % % NN cord-010119-t1x9gknd 12368 40 in in IN cord-010119-t1x9gknd 12368 41 2016 2016 CD cord-010119-t1x9gknd 12368 42 ( ( -LRB- cord-010119-t1x9gknd 12368 43 see see VB cord-010119-t1x9gknd 12368 44 table table NN cord-010119-t1x9gknd 12368 45 ) ) -RRB- cord-010119-t1x9gknd 12368 46 . . . cord-010119-t1x9gknd 12369 1 Importantly importantly RB cord-010119-t1x9gknd 12369 2 , , , cord-010119-t1x9gknd 12369 3 this this DT cord-010119-t1x9gknd 12369 4 occurred occur VBD cord-010119-t1x9gknd 12369 5 despite despite IN cord-010119-t1x9gknd 12369 6 a a DT cord-010119-t1x9gknd 12369 7 greater great JJR cord-010119-t1x9gknd 12369 8 than than IN cord-010119-t1x9gknd 12369 9 30 30 CD cord-010119-t1x9gknd 12369 10 % % NN cord-010119-t1x9gknd 12369 11 increase increase NN cord-010119-t1x9gknd 12369 12 in in IN cord-010119-t1x9gknd 12369 13 platelet platelet NN cord-010119-t1x9gknd 12369 14 inventory inventory NN cord-010119-t1x9gknd 12369 15 between between IN cord-010119-t1x9gknd 12369 16 2014 2014 CD cord-010119-t1x9gknd 12369 17 and and CC cord-010119-t1x9gknd 12369 18 2016 2016 CD cord-010119-t1x9gknd 12369 19 and and CC cord-010119-t1x9gknd 12369 20 resulted result VBD cord-010119-t1x9gknd 12369 21 in in IN cord-010119-t1x9gknd 12369 22 cost cost NN cord-010119-t1x9gknd 12369 23 savings saving NNS cord-010119-t1x9gknd 12369 24 of of IN cord-010119-t1x9gknd 12369 25 over over IN cord-010119-t1x9gknd 12369 26 $ $ $ cord-010119-t1x9gknd 12369 27 60,000 60,000 CD cord-010119-t1x9gknd 12369 28 in in IN cord-010119-t1x9gknd 12369 29 this this DT cord-010119-t1x9gknd 12369 30 period period NN cord-010119-t1x9gknd 12369 31 . . . cord-010119-t1x9gknd 12370 1 Conclusion conclusion NN cord-010119-t1x9gknd 12370 2 : : : cord-010119-t1x9gknd 12371 1 Study study NN cord-010119-t1x9gknd 12371 2 limitations limitation NNS cord-010119-t1x9gknd 12371 3 included include VBD cord-010119-t1x9gknd 12371 4 restricting restrict VBG cord-010119-t1x9gknd 12371 5 data datum NNS cord-010119-t1x9gknd 12371 6 collection collection NN cord-010119-t1x9gknd 12371 7 to to IN cord-010119-t1x9gknd 12371 8 one one CD cord-010119-t1x9gknd 12371 9 campus campus NN cord-010119-t1x9gknd 12371 10 . . . cord-010119-t1x9gknd 12372 1 The the DT cord-010119-t1x9gknd 12372 2 option option NN cord-010119-t1x9gknd 12372 3 to to TO cord-010119-t1x9gknd 12372 4 transfer transfer VB cord-010119-t1x9gknd 12372 5 expiring expire VBG cord-010119-t1x9gknd 12372 6 platelet platelet NN cord-010119-t1x9gknd 12372 7 units unit NNS cord-010119-t1x9gknd 12372 8 to to IN cord-010119-t1x9gknd 12372 9 another another DT cord-010119-t1x9gknd 12372 10 blood blood NN cord-010119-t1x9gknd 12372 11 bank bank NN cord-010119-t1x9gknd 12372 12 was be VBD cord-010119-t1x9gknd 12372 13 available available JJ cord-010119-t1x9gknd 12372 14 to to IN cord-010119-t1x9gknd 12372 15 all all DT cord-010119-t1x9gknd 12372 16 4 4 CD cord-010119-t1x9gknd 12372 17 participating participate VBG cord-010119-t1x9gknd 12372 18 sister sister NN cord-010119-t1x9gknd 12372 19 hospitals hospital NNS cord-010119-t1x9gknd 12372 20 . . . cord-010119-t1x9gknd 12373 1 It -PRON- PRP cord-010119-t1x9gknd 12373 2 would would MD cord-010119-t1x9gknd 12373 3 have have VB cord-010119-t1x9gknd 12373 4 been be VBN cord-010119-t1x9gknd 12373 5 interesting interesting JJ cord-010119-t1x9gknd 12373 6 to to TO cord-010119-t1x9gknd 12373 7 see see VB cord-010119-t1x9gknd 12373 8 the the DT cord-010119-t1x9gknd 12373 9 effect effect NN cord-010119-t1x9gknd 12373 10 of of IN cord-010119-t1x9gknd 12373 11 the the DT cord-010119-t1x9gknd 12373 12 report report NN cord-010119-t1x9gknd 12373 13 on on IN cord-010119-t1x9gknd 12373 14 those those DT cord-010119-t1x9gknd 12373 15 hospitals hospital NNS cord-010119-t1x9gknd 12373 16 which which WDT cord-010119-t1x9gknd 12373 17 have have VBP cord-010119-t1x9gknd 12373 18 lower low JJR cord-010119-t1x9gknd 12373 19 transfusion transfusion NN cord-010119-t1x9gknd 12373 20 rates rate NNS cord-010119-t1x9gknd 12373 21 and and CC cord-010119-t1x9gknd 12373 22 different different JJ cord-010119-t1x9gknd 12373 23 ordering ordering NN cord-010119-t1x9gknd 12373 24 practices practice NNS cord-010119-t1x9gknd 12373 25 . . . cord-010119-t1x9gknd 12374 1 Aside aside RB cord-010119-t1x9gknd 12374 2 from from IN cord-010119-t1x9gknd 12374 3 lowering lower VBG cord-010119-t1x9gknd 12374 4 platelet platelet NN cord-010119-t1x9gknd 12374 5 wastage wastage NN cord-010119-t1x9gknd 12374 6 within within IN cord-010119-t1x9gknd 12374 7 2 2 CD cord-010119-t1x9gknd 12374 8 years year NNS cord-010119-t1x9gknd 12374 9 of of IN cord-010119-t1x9gknd 12374 10 implementation implementation NN cord-010119-t1x9gknd 12374 11 , , , cord-010119-t1x9gknd 12374 12 additional additional JJ cord-010119-t1x9gknd 12374 13 benefits benefit NNS cord-010119-t1x9gknd 12374 14 to to IN cord-010119-t1x9gknd 12374 15 the the DT cord-010119-t1x9gknd 12374 16 report report NN cord-010119-t1x9gknd 12374 17 included include VBD cord-010119-t1x9gknd 12374 18 facilitating facilitate VBG cord-010119-t1x9gknd 12374 19 ordering order VBG cord-010119-t1x9gknd 12374 20 from from IN cord-010119-t1x9gknd 12374 21 the the DT cord-010119-t1x9gknd 12374 22 blood blood NN cord-010119-t1x9gknd 12374 23 supplier supplier NN cord-010119-t1x9gknd 12374 24 . . . cord-010119-t1x9gknd 12375 1 Cornerstones cornerstone NNS cord-010119-t1x9gknd 12375 2 of of IN cord-010119-t1x9gknd 12375 3 a a DT cord-010119-t1x9gknd 12375 4 successful successful JJ cord-010119-t1x9gknd 12375 5 inventory inventory NN cord-010119-t1x9gknd 12375 6 management management NN cord-010119-t1x9gknd 12375 7 plan plan NN cord-010119-t1x9gknd 12375 8 include include VBP cord-010119-t1x9gknd 12375 9 daily daily JJ cord-010119-t1x9gknd 12375 10 inventory inventory NN cord-010119-t1x9gknd 12375 11 monitoring monitoring NN cord-010119-t1x9gknd 12375 12 and and CC cord-010119-t1x9gknd 12375 13 , , , cord-010119-t1x9gknd 12375 14 ideally ideally RB cord-010119-t1x9gknd 12375 15 , , , cord-010119-t1x9gknd 12375 16 coordinated coordinated JJ cord-010119-t1x9gknd 12375 17 system system NN cord-010119-t1x9gknd 12375 18 - - HYPH cord-010119-t1x9gknd 12375 19 wide wide JJ cord-010119-t1x9gknd 12375 20 efforts effort NNS cord-010119-t1x9gknd 12375 21 to to TO cord-010119-t1x9gknd 12375 22 share share VB cord-010119-t1x9gknd 12375 23 platelet platelet NN cord-010119-t1x9gknd 12375 24 units unit NNS cord-010119-t1x9gknd 12375 25 . . . cord-010119-t1x9gknd 12376 1 We -PRON- PRP cord-010119-t1x9gknd 12376 2 have have VBP cord-010119-t1x9gknd 12376 3 shown show VBN cord-010119-t1x9gknd 12376 4 achievement achievement NN cord-010119-t1x9gknd 12376 5 of of IN cord-010119-t1x9gknd 12376 6 this this DT cord-010119-t1x9gknd 12376 7 end end NN cord-010119-t1x9gknd 12376 8 is be VBZ cord-010119-t1x9gknd 12376 9 facilitated facilitate VBN cord-010119-t1x9gknd 12376 10 by by IN cord-010119-t1x9gknd 12376 11 a a DT cord-010119-t1x9gknd 12376 12 customized customized JJ cord-010119-t1x9gknd 12376 13 daily daily JJ cord-010119-t1x9gknd 12376 14 Platelet Platelet NNP cord-010119-t1x9gknd 12376 15 Inventory Inventory NNP cord-010119-t1x9gknd 12376 16 Report Report NNP cord-010119-t1x9gknd 12376 17 -an -an NNS cord-010119-t1x9gknd 12376 18 efficacious efficacious JJ cord-010119-t1x9gknd 12376 19 and and CC cord-010119-t1x9gknd 12376 20 easily easily RB cord-010119-t1x9gknd 12376 21 adaptable adaptable JJ cord-010119-t1x9gknd 12376 22 tool tool NN cord-010119-t1x9gknd 12376 23 with with IN cord-010119-t1x9gknd 12376 24 demonstrable demonstrable JJ cord-010119-t1x9gknd 12376 25 gains gain NNS cord-010119-t1x9gknd 12376 26 . . . cord-010119-t1x9gknd 12377 1 Valerie Valerie NNP cord-010119-t1x9gknd 12377 2 Halling Halling NNP cord-010119-t1x9gknd 12377 3 * * NFP cord-010119-t1x9gknd 12377 4 1 1 CD cord-010119-t1x9gknd 12377 5 , , , cord-010119-t1x9gknd 12377 6 Lisa Lisa NNP cord-010119-t1x9gknd 12377 7 Marie Marie NNP cord-010119-t1x9gknd 12377 8 Button Button NNP cord-010119-t1x9gknd 12377 9 2 2 CD cord-010119-t1x9gknd 12377 10 , , , cord-010119-t1x9gknd 12377 11 Lori Lori NNP cord-010119-t1x9gknd 12377 12 Scanlan Scanlan NNP cord-010119-t1x9gknd 12377 13 - - HYPH cord-010119-t1x9gknd 12377 14 Hanson Hanson NNP cord-010119-t1x9gknd 12377 15 2 2 CD cord-010119-t1x9gknd 12377 16 , , , cord-010119-t1x9gknd 12377 17 Karen Karen NNP cord-010119-t1x9gknd 12377 18 Koch Koch NNP cord-010119-t1x9gknd 12377 19 2 2 CD cord-010119-t1x9gknd 12377 20 , , , cord-010119-t1x9gknd 12377 21 Janet Janet NNP cord-010119-t1x9gknd 12377 22 Finley Finley NNP cord-010119-t1x9gknd 12377 23 2 2 CD cord-010119-t1x9gknd 12377 24 , , , cord-010119-t1x9gknd 12377 25 Deepi Deepi NNP cord-010119-t1x9gknd 12377 26 Goyal Goyal NNP cord-010119-t1x9gknd 12377 27 2 2 CD cord-010119-t1x9gknd 12377 28 and and CC cord-010119-t1x9gknd 12377 29 Camille Camille NNP cord-010119-t1x9gknd 12377 30 van van NNP cord-010119-t1x9gknd 12377 31 Buskirk Buskirk NNP cord-010119-t1x9gknd 12377 32 3 3 CD cord-010119-t1x9gknd 12377 33 . . . cord-010119-t1x9gknd 12378 1 1 1 CD cord-010119-t1x9gknd 12378 2 Mayo Mayo NNP cord-010119-t1x9gknd 12378 3 Clinic Clinic NNP cord-010119-t1x9gknd 12378 4 - - HYPH cord-010119-t1x9gknd 12378 5 Rochester Rochester NNP cord-010119-t1x9gknd 12378 6 , , , cord-010119-t1x9gknd 12378 7 2 2 CD cord-010119-t1x9gknd 12378 8 Mayo Mayo NNP cord-010119-t1x9gknd 12378 9 Clinic Clinic NNP cord-010119-t1x9gknd 12378 10 , , , cord-010119-t1x9gknd 12378 11 3 3 CD cord-010119-t1x9gknd 12378 12 Mayo Mayo NNP cord-010119-t1x9gknd 12378 13 Clinic Clinic NNP cord-010119-t1x9gknd 12378 14 Rochester Rochester NNP cord-010119-t1x9gknd 12378 15 Background Background NNP cord-010119-t1x9gknd 12378 16 / / SYM cord-010119-t1x9gknd 12378 17 Case Case NNP cord-010119-t1x9gknd 12378 18 Studies Studies NNPS cord-010119-t1x9gknd 12378 19 : : : cord-010119-t1x9gknd 12378 20 Transfusions transfusion NNS cord-010119-t1x9gknd 12378 21 in in IN cord-010119-t1x9gknd 12378 22 the the DT cord-010119-t1x9gknd 12378 23 Emergency Emergency NNP cord-010119-t1x9gknd 12378 24 Department Department NNP cord-010119-t1x9gknd 12378 25 of of IN cord-010119-t1x9gknd 12378 26 a a DT cord-010119-t1x9gknd 12378 27 Level level NN cord-010119-t1x9gknd 12379 1 I -PRON- PRP cord-010119-t1x9gknd 12379 2 Trauma Trauma NNP cord-010119-t1x9gknd 12379 3 Center Center NNP cord-010119-t1x9gknd 12379 4 were be VBD cord-010119-t1x9gknd 12379 5 ordered order VBN cord-010119-t1x9gknd 12379 6 using use VBG cord-010119-t1x9gknd 12379 7 a a DT cord-010119-t1x9gknd 12379 8 handwritten handwritten JJ cord-010119-t1x9gknd 12379 9 order order NN cord-010119-t1x9gknd 12379 10 form form NN cord-010119-t1x9gknd 12379 11 . . . cord-010119-t1x9gknd 12380 1 The the DT cord-010119-t1x9gknd 12380 2 Transfusion Transfusion NNP cord-010119-t1x9gknd 12380 3 Lab Lab NNP cord-010119-t1x9gknd 12380 4 's 's POS cord-010119-t1x9gknd 12380 5 ( ( -LRB- cord-010119-t1x9gknd 12380 6 TL TL NNP cord-010119-t1x9gknd 12380 7 ) ) -RRB- cord-010119-t1x9gknd 12380 8 management management NN cord-010119-t1x9gknd 12380 9 team team NN cord-010119-t1x9gknd 12380 10 and and CC cord-010119-t1x9gknd 12380 11 Medical Medical NNP cord-010119-t1x9gknd 12380 12 Director Director NNP cord-010119-t1x9gknd 12380 13 met meet VBD cord-010119-t1x9gknd 12380 14 with with IN cord-010119-t1x9gknd 12380 15 Emergency Emergency NNP cord-010119-t1x9gknd 12380 16 Department Department NNP cord-010119-t1x9gknd 12380 17 ( ( -LRB- cord-010119-t1x9gknd 12380 18 ED ED NNP cord-010119-t1x9gknd 12380 19 ) ) -RRB- cord-010119-t1x9gknd 12380 20 leadership leadership NN cord-010119-t1x9gknd 12380 21 and and CC cord-010119-t1x9gknd 12380 22 IT IT NNP cord-010119-t1x9gknd 12380 23 resources resource VBZ cord-010119-t1x9gknd 12380 24 in in IN cord-010119-t1x9gknd 12380 25 2014 2014 CD cord-010119-t1x9gknd 12380 26 to to TO cord-010119-t1x9gknd 12380 27 define define VB cord-010119-t1x9gknd 12380 28 the the DT cord-010119-t1x9gknd 12380 29 needs need NNS cord-010119-t1x9gknd 12380 30 of of IN cord-010119-t1x9gknd 12380 31 a a DT cord-010119-t1x9gknd 12380 32 successful successful JJ cord-010119-t1x9gknd 12380 33 electronic electronic JJ cord-010119-t1x9gknd 12380 34 blood blood NN cord-010119-t1x9gknd 12380 35 transfusion transfusion NN cord-010119-t1x9gknd 12380 36 system system NN cord-010119-t1x9gknd 12380 37 . . . cord-010119-t1x9gknd 12381 1 The the DT cord-010119-t1x9gknd 12381 2 handwritten handwritten JJ cord-010119-t1x9gknd 12381 3 order order NN cord-010119-t1x9gknd 12381 4 forms form NNS cord-010119-t1x9gknd 12381 5 had have VBD cord-010119-t1x9gknd 12381 6 several several JJ cord-010119-t1x9gknd 12381 7 potential potential JJ cord-010119-t1x9gknd 12381 8 error error NN cord-010119-t1x9gknd 12381 9 sources source NNS cord-010119-t1x9gknd 12381 10 which which WDT cord-010119-t1x9gknd 12381 11 could could MD cord-010119-t1x9gknd 12381 12 lead lead VB cord-010119-t1x9gknd 12381 13 to to IN cord-010119-t1x9gknd 12381 14 a a DT cord-010119-t1x9gknd 12381 15 delay delay NN cord-010119-t1x9gknd 12381 16 in in IN cord-010119-t1x9gknd 12381 17 filling fill VBG cord-010119-t1x9gknd 12381 18 the the DT cord-010119-t1x9gknd 12381 19 order order NN cord-010119-t1x9gknd 12381 20 pending pende VBG cord-010119-t1x9gknd 12381 21 correction correction NN cord-010119-t1x9gknd 12381 22 ( ( -LRB- cord-010119-t1x9gknd 12381 23 in in IN cord-010119-t1x9gknd 12381 24 the the DT cord-010119-t1x9gknd 12381 25 best good JJS cord-010119-t1x9gknd 12381 26 of of IN cord-010119-t1x9gknd 12381 27 circumstances circumstance NNS cord-010119-t1x9gknd 12381 28 ) ) -RRB- cord-010119-t1x9gknd 12381 29 or or CC cord-010119-t1x9gknd 12381 30 could could MD cord-010119-t1x9gknd 12381 31 lead lead VB cord-010119-t1x9gknd 12381 32 to to IN cord-010119-t1x9gknd 12381 33 transfusing transfuse VBG cord-010119-t1x9gknd 12381 34 the the DT cord-010119-t1x9gknd 12381 35 wrong wrong JJ cord-010119-t1x9gknd 12381 36 patient patient NN cord-010119-t1x9gknd 12381 37 or or CC cord-010119-t1x9gknd 12381 38 the the DT cord-010119-t1x9gknd 12381 39 wrong wrong JJ cord-010119-t1x9gknd 12381 40 product product NN cord-010119-t1x9gknd 12381 41 if if IN cord-010119-t1x9gknd 12381 42 the the DT cord-010119-t1x9gknd 12381 43 error error NN cord-010119-t1x9gknd 12381 44 was be VBD cord-010119-t1x9gknd 12381 45 not not RB cord-010119-t1x9gknd 12381 46 detected detect VBN cord-010119-t1x9gknd 12381 47 . . . cord-010119-t1x9gknd 12382 1 The the DT cord-010119-t1x9gknd 12382 2 potential potential JJ cord-010119-t1x9gknd 12382 3 error error NN cord-010119-t1x9gknd 12382 4 sources source NNS cord-010119-t1x9gknd 12382 5 included include VBD cord-010119-t1x9gknd 12382 6 clerical clerical JJ cord-010119-t1x9gknd 12382 7 errors error NNS cord-010119-t1x9gknd 12382 8 involving involve VBG cord-010119-t1x9gknd 12382 9 the the DT cord-010119-t1x9gknd 12382 10 patient patient NN cord-010119-t1x9gknd 12382 11 's 's POS cord-010119-t1x9gknd 12382 12 name name NN cord-010119-t1x9gknd 12382 13 or or CC cord-010119-t1x9gknd 12382 14 medical medical JJ cord-010119-t1x9gknd 12382 15 record record NN cord-010119-t1x9gknd 12382 16 number number NN cord-010119-t1x9gknd 12382 17 ( ( -LRB- cord-010119-t1x9gknd 12382 18 MRN MRN NNP cord-010119-t1x9gknd 12382 19 ) ) -RRB- cord-010119-t1x9gknd 12382 20 , , , cord-010119-t1x9gknd 12382 21 writing write VBG cord-010119-t1x9gknd 12382 22 two two CD cord-010119-t1x9gknd 12382 23 different different JJ cord-010119-t1x9gknd 12382 24 names name NNS cord-010119-t1x9gknd 12382 25 on on IN cord-010119-t1x9gknd 12382 26 the the DT cord-010119-t1x9gknd 12382 27 order order NN cord-010119-t1x9gknd 12382 28 form form NN cord-010119-t1x9gknd 12382 29 ( ( -LRB- cord-010119-t1x9gknd 12382 30 because because IN cord-010119-t1x9gknd 12382 31 there there EX cord-010119-t1x9gknd 12382 32 were be VBD cord-010119-t1x9gknd 12382 33 two two CD cord-010119-t1x9gknd 12382 34 locations location NNS cord-010119-t1x9gknd 12382 35 to to TO cord-010119-t1x9gknd 12382 36 record record VB cord-010119-t1x9gknd 12382 37 patient patient NN cord-010119-t1x9gknd 12382 38 name name NN cord-010119-t1x9gknd 12382 39 ) ) -RRB- cord-010119-t1x9gknd 12382 40 , , , cord-010119-t1x9gknd 12382 41 two two CD cord-010119-t1x9gknd 12382 42 product product NN cord-010119-t1x9gknd 12382 43 types type NNS cord-010119-t1x9gknd 12382 44 ordered order VBN cord-010119-t1x9gknd 12382 45 on on IN cord-010119-t1x9gknd 12382 46 one one CD cord-010119-t1x9gknd 12382 47 form form NN cord-010119-t1x9gknd 12382 48 when when WRB cord-010119-t1x9gknd 12382 49 the the DT cord-010119-t1x9gknd 12382 50 requirement requirement NN cord-010119-t1x9gknd 12382 51 is be VBZ cord-010119-t1x9gknd 12382 52 for for IN cord-010119-t1x9gknd 12382 53 one one CD cord-010119-t1x9gknd 12382 54 product product NN cord-010119-t1x9gknd 12382 55 type type NN cord-010119-t1x9gknd 12382 56 per per IN cord-010119-t1x9gknd 12382 57 order order NN cord-010119-t1x9gknd 12382 58 , , , cord-010119-t1x9gknd 12382 59 no no DT cord-010119-t1x9gknd 12382 60 priority priority NN cord-010119-t1x9gknd 12382 61 indicated indicate VBN cord-010119-t1x9gknd 12382 62 ( ( -LRB- cord-010119-t1x9gknd 12382 63 STAT stat NN cord-010119-t1x9gknd 12382 64 or or CC cord-010119-t1x9gknd 12382 65 Routine Routine NNP cord-010119-t1x9gknd 12382 66 ) ) -RRB- cord-010119-t1x9gknd 12382 67 , , , cord-010119-t1x9gknd 12382 68 or or CC cord-010119-t1x9gknd 12382 69 not not RB cord-010119-t1x9gknd 12382 70 including include VBG cord-010119-t1x9gknd 12382 71 the the DT cord-010119-t1x9gknd 12382 72 prescriber prescriber NN cord-010119-t1x9gknd 12382 73 call call VB cord-010119-t1x9gknd 12382 74 - - HYPH cord-010119-t1x9gknd 12382 75 back back RP cord-010119-t1x9gknd 12382 76 information information NN cord-010119-t1x9gknd 12382 77 . . . cord-010119-t1x9gknd 12383 1 The the DT cord-010119-t1x9gknd 12383 2 number number NN cord-010119-t1x9gknd 12383 3 of of IN cord-010119-t1x9gknd 12383 4 ED ED NNP cord-010119-t1x9gknd 12383 5 reported report VBD cord-010119-t1x9gknd 12383 6 transfusion transfusion NN cord-010119-t1x9gknd 12383 7 related relate VBN cord-010119-t1x9gknd 12383 8 events event NNS cord-010119-t1x9gknd 12383 9 in in IN cord-010119-t1x9gknd 12383 10 2013 2013 CD cord-010119-t1x9gknd 12383 11 and and CC cord-010119-t1x9gknd 12383 12 2014 2014 CD cord-010119-t1x9gknd 12383 13 were be VBD cord-010119-t1x9gknd 12383 14 63/1187 63/1187 CD cord-010119-t1x9gknd 12383 15 ( ( -LRB- cord-010119-t1x9gknd 12383 16 events event NNS cord-010119-t1x9gknd 12383 17 / / SYM cord-010119-t1x9gknd 12383 18 ED ED NNP cord-010119-t1x9gknd 12383 19 transfusions transfusion NNS cord-010119-t1x9gknd 12383 20 2013 2013 CD cord-010119-t1x9gknd 12383 21 - - SYM cord-010119-t1x9gknd 12383 22 2014 2014 CD cord-010119-t1x9gknd 12383 23 ) ) -RRB- cord-010119-t1x9gknd 12383 24 . . . cord-010119-t1x9gknd 12384 1 Study Study NNP cord-010119-t1x9gknd 12384 2 Design Design NNP cord-010119-t1x9gknd 12384 3 / / SYM cord-010119-t1x9gknd 12384 4 Method method NN cord-010119-t1x9gknd 12384 5 : : : cord-010119-t1x9gknd 12385 1 Electronic electronic JJ cord-010119-t1x9gknd 12385 2 ordering ordering NN cord-010119-t1x9gknd 12385 3 for for IN cord-010119-t1x9gknd 12385 4 the the DT cord-010119-t1x9gknd 12385 5 ED ED NNP cord-010119-t1x9gknd 12385 6 was be VBD cord-010119-t1x9gknd 12385 7 implemented implement VBN cord-010119-t1x9gknd 12385 8 March March NNP cord-010119-t1x9gknd 12385 9 31 31 CD cord-010119-t1x9gknd 12385 10 st st NNP cord-010119-t1x9gknd 12385 11 2015 2015 CD cord-010119-t1x9gknd 12385 12 . . . cord-010119-t1x9gknd 12386 1 Any any DT cord-010119-t1x9gknd 12386 2 transfusion transfusion NN cord-010119-t1x9gknd 12386 3 orders order NNS cord-010119-t1x9gknd 12386 4 generated generate VBN cord-010119-t1x9gknd 12386 5 from from IN cord-010119-t1x9gknd 12386 6 the the DT cord-010119-t1x9gknd 12386 7 ED ED NNP cord-010119-t1x9gknd 12386 8 are be VBP cord-010119-t1x9gknd 12386 9 now now RB cord-010119-t1x9gknd 12386 10 electronic electronic JJ cord-010119-t1x9gknd 12386 11 , , , cord-010119-t1x9gknd 12386 12 unless unless IN cord-010119-t1x9gknd 12386 13 in in IN cord-010119-t1x9gknd 12386 14 the the DT cord-010119-t1x9gknd 12386 15 case case NN cord-010119-t1x9gknd 12386 16 of of IN cord-010119-t1x9gknd 12386 17 electronic electronic JJ cord-010119-t1x9gknd 12386 18 downtime downtime NN cord-010119-t1x9gknd 12386 19 . . . cord-010119-t1x9gknd 12387 1 The the DT cord-010119-t1x9gknd 12387 2 system system NN cord-010119-t1x9gknd 12387 3 electronically electronically RB cord-010119-t1x9gknd 12387 4 fills fill VBZ cord-010119-t1x9gknd 12387 5 in in IN cord-010119-t1x9gknd 12387 6 the the DT cord-010119-t1x9gknd 12387 7 patient patient NN cord-010119-t1x9gknd 12387 8 's 's POS cord-010119-t1x9gknd 12387 9 name name NN cord-010119-t1x9gknd 12387 10 and and CC cord-010119-t1x9gknd 12387 11 MRN MRN NNP cord-010119-t1x9gknd 12387 12 , , , cord-010119-t1x9gknd 12387 13 controls control VBZ cord-010119-t1x9gknd 12387 14 for for IN cord-010119-t1x9gknd 12387 15 the the DT cord-010119-t1x9gknd 12387 16 type type NN cord-010119-t1x9gknd 12387 17 of of IN cord-010119-t1x9gknd 12387 18 blood blood NN cord-010119-t1x9gknd 12387 19 product product NN cord-010119-t1x9gknd 12387 20 being be VBG cord-010119-t1x9gknd 12387 21 ordered order VBN cord-010119-t1x9gknd 12387 22 , , , cord-010119-t1x9gknd 12387 23 requires require VBZ cord-010119-t1x9gknd 12387 24 an an DT cord-010119-t1x9gknd 12387 25 order order NN cord-010119-t1x9gknd 12387 26 priority priority NN cord-010119-t1x9gknd 12387 27 and and CC cord-010119-t1x9gknd 12387 28 provides provide VBZ cord-010119-t1x9gknd 12387 29 service service NN cord-010119-t1x9gknd 12387 30 contact contact NN cord-010119-t1x9gknd 12387 31 information information NN cord-010119-t1x9gknd 12387 32 . . . cord-010119-t1x9gknd 12388 1 It -PRON- PRP cord-010119-t1x9gknd 12388 2 was be VBD cord-010119-t1x9gknd 12388 3 designed design VBN cord-010119-t1x9gknd 12388 4 to to TO cord-010119-t1x9gknd 12388 5 accommodate accommodate VB cord-010119-t1x9gknd 12388 6 transfusion transfusion NN cord-010119-t1x9gknd 12388 7 ordering ordering NN cord-010119-t1x9gknd 12388 8 needs need NNS cord-010119-t1x9gknd 12388 9 for for IN cord-010119-t1x9gknd 12388 10 adults adult NNS cord-010119-t1x9gknd 12388 11 , , , cord-010119-t1x9gknd 12388 12 pediatric pediatric JJ cord-010119-t1x9gknd 12388 13 patients patient NNS cord-010119-t1x9gknd 12389 1 < < NNP cord-010119-t1x9gknd 12389 2 35 35 CD cord-010119-t1x9gknd 12389 3 kg kg NNS cord-010119-t1x9gknd 12389 4 and and CC cord-010119-t1x9gknd 12389 5 pediatric pediatric JJ cord-010119-t1x9gknd 12389 6 patients patient NNS cord-010119-t1x9gknd 12389 7 > > XX cord-010119-t1x9gknd 12389 8 35 35 CD cord-010119-t1x9gknd 12389 9 kg kg NNS cord-010119-t1x9gknd 12389 10 . . . cord-010119-t1x9gknd 12390 1 252A 252a CD cord-010119-t1x9gknd 12390 2 TRANSFUSION transfusion NN cord-010119-t1x9gknd 12390 3 orders order NNS cord-010119-t1x9gknd 12390 4 had have VBD cord-010119-t1x9gknd 12390 5 three three CD cord-010119-t1x9gknd 12390 6 critical critical JJ cord-010119-t1x9gknd 12390 7 fields field NNS cord-010119-t1x9gknd 12390 8 identified identify VBD cord-010119-t1x9gknd 12390 9 that that WDT cord-010119-t1x9gknd 12390 10 are be VBP cord-010119-t1x9gknd 12390 11 required require VBN cord-010119-t1x9gknd 12390 12 for for IN cord-010119-t1x9gknd 12390 13 the the DT cord-010119-t1x9gknd 12390 14 order order NN cord-010119-t1x9gknd 12390 15 to to TO cord-010119-t1x9gknd 12390 16 be be VB cord-010119-t1x9gknd 12390 17 processed process VBN cord-010119-t1x9gknd 12390 18 including include VBG cord-010119-t1x9gknd 12390 19 patient patient JJ cord-010119-t1x9gknd 12390 20 weight weight NN cord-010119-t1x9gknd 12390 21 , , , cord-010119-t1x9gknd 12390 22 product product NN cord-010119-t1x9gknd 12390 23 volume volume NN cord-010119-t1x9gknd 12390 24 , , , cord-010119-t1x9gknd 12390 25 and and CC cord-010119-t1x9gknd 12390 26 infusion infusion NN cord-010119-t1x9gknd 12390 27 rate rate NN cord-010119-t1x9gknd 12390 28 . . . cord-010119-t1x9gknd 12391 1 The the DT cord-010119-t1x9gknd 12391 2 electronic electronic JJ cord-010119-t1x9gknd 12391 3 system system NN cord-010119-t1x9gknd 12391 4 was be VBD cord-010119-t1x9gknd 12391 5 designed design VBN cord-010119-t1x9gknd 12391 6 so so IN cord-010119-t1x9gknd 12391 7 that that IN cord-010119-t1x9gknd 12391 8 an an DT cord-010119-t1x9gknd 12391 9 order order NN cord-010119-t1x9gknd 12391 10 can can MD cord-010119-t1x9gknd 12391 11 not not RB cord-010119-t1x9gknd 12391 12 be be VB cord-010119-t1x9gknd 12391 13 submitted submit VBN cord-010119-t1x9gknd 12391 14 unless unless IN cord-010119-t1x9gknd 12391 15 all all DT cord-010119-t1x9gknd 12391 16 critical critical JJ cord-010119-t1x9gknd 12391 17 fields field NNS cord-010119-t1x9gknd 12391 18 are be VBP cord-010119-t1x9gknd 12391 19 completed complete VBN cord-010119-t1x9gknd 12391 20 . . . cord-010119-t1x9gknd 12392 1 Results/ Results/ . cord-010119-t1x9gknd 12393 1 Finding finding NN cord-010119-t1x9gknd 12393 2 : : : cord-010119-t1x9gknd 12394 1 The the DT cord-010119-t1x9gknd 12394 2 electronic electronic JJ cord-010119-t1x9gknd 12394 3 ordering ordering NN cord-010119-t1x9gknd 12394 4 system system NN cord-010119-t1x9gknd 12394 5 has have VBZ cord-010119-t1x9gknd 12394 6 been be VBN cord-010119-t1x9gknd 12394 7 in in IN cord-010119-t1x9gknd 12394 8 place place NN cord-010119-t1x9gknd 12394 9 for for IN cord-010119-t1x9gknd 12394 10 2 2 CD cord-010119-t1x9gknd 12394 11 years year NNS cord-010119-t1x9gknd 12394 12 ( ( -LRB- cord-010119-t1x9gknd 12394 13 April April NNP cord-010119-t1x9gknd 12394 14 2015 2015 CD cord-010119-t1x9gknd 12394 15 -March -march WDT cord-010119-t1x9gknd 12394 16 2017 2017 CD cord-010119-t1x9gknd 12394 17 ) ) -RRB- cord-010119-t1x9gknd 12394 18 , , , cord-010119-t1x9gknd 12394 19 and and CC cord-010119-t1x9gknd 12394 20 during during IN cord-010119-t1x9gknd 12394 21 that that DT cord-010119-t1x9gknd 12394 22 time time NN cord-010119-t1x9gknd 12394 23 there there EX cord-010119-t1x9gknd 12394 24 was be VBD cord-010119-t1x9gknd 12394 25 1 1 CD cord-010119-t1x9gknd 12394 26 instance instance NN cord-010119-t1x9gknd 12394 27 of of IN cord-010119-t1x9gknd 12394 28 blood blood NN cord-010119-t1x9gknd 12394 29 being being NN cord-010119-t1x9gknd 12394 30 ordered order VBN cord-010119-t1x9gknd 12394 31 for for IN cord-010119-t1x9gknd 12394 32 an an DT cord-010119-t1x9gknd 12394 33 unintended unintended JJ cord-010119-t1x9gknd 12394 34 patient patient NN cord-010119-t1x9gknd 12394 35 0.09 0.09 CD cord-010119-t1x9gknd 12394 36 % % NN cord-010119-t1x9gknd 12394 37 ( ( -LRB- cord-010119-t1x9gknd 12394 38 1/1081 1/1081 CD cord-010119-t1x9gknd 12394 39 ) ) -RRB- cord-010119-t1x9gknd 12394 40 . . . cord-010119-t1x9gknd 12395 1 This this DT cord-010119-t1x9gknd 12395 2 was be VBD cord-010119-t1x9gknd 12395 3 because because IN cord-010119-t1x9gknd 12395 4 a a DT cord-010119-t1x9gknd 12395 5 previous previous JJ cord-010119-t1x9gknd 12395 6 patient patient NN cord-010119-t1x9gknd 12395 7 's 's POS cord-010119-t1x9gknd 12395 8 medical medical JJ cord-010119-t1x9gknd 12395 9 record record NN cord-010119-t1x9gknd 12395 10 was be VBD cord-010119-t1x9gknd 12395 11 accessed access VBN cord-010119-t1x9gknd 12395 12 rather rather RB cord-010119-t1x9gknd 12395 13 than than IN cord-010119-t1x9gknd 12395 14 the the DT cord-010119-t1x9gknd 12395 15 intended intended JJ cord-010119-t1x9gknd 12395 16 patient patient NN cord-010119-t1x9gknd 12395 17 's 's POS cord-010119-t1x9gknd 12395 18 medical medical JJ cord-010119-t1x9gknd 12395 19 record record NN cord-010119-t1x9gknd 12395 20 . . . cord-010119-t1x9gknd 12396 1 There there EX cord-010119-t1x9gknd 12396 2 have have VBP cord-010119-t1x9gknd 12396 3 been be VBN cord-010119-t1x9gknd 12396 4 no no DT cord-010119-t1x9gknd 12396 5 instances instance NNS cord-010119-t1x9gknd 12396 6 of of IN cord-010119-t1x9gknd 12396 7 clerical clerical JJ cord-010119-t1x9gknd 12396 8 errors error NNS cord-010119-t1x9gknd 12396 9 ( ( -LRB- cord-010119-t1x9gknd 12396 10 name name NN cord-010119-t1x9gknd 12396 11 misspelled misspell VBN cord-010119-t1x9gknd 12396 12 or or CC cord-010119-t1x9gknd 12396 13 MRN MRN NNP cord-010119-t1x9gknd 12396 14 transposition transposition NN cord-010119-t1x9gknd 12396 15 etc etc NN cord-010119-t1x9gknd 12396 16 . . . cord-010119-t1x9gknd 12396 17 ) ) -RRB- cord-010119-t1x9gknd 12396 18 , , , cord-010119-t1x9gknd 12396 19 missing miss VBG cord-010119-t1x9gknd 12396 20 service service NN cord-010119-t1x9gknd 12396 21 contact contact NN cord-010119-t1x9gknd 12396 22 information information NN cord-010119-t1x9gknd 12396 23 , , , cord-010119-t1x9gknd 12396 24 missing miss VBG cord-010119-t1x9gknd 12396 25 order order NN cord-010119-t1x9gknd 12396 26 priority priority NN cord-010119-t1x9gknd 12396 27 information information NN cord-010119-t1x9gknd 12396 28 , , , cord-010119-t1x9gknd 12396 29 more more JJR cord-010119-t1x9gknd 12396 30 than than IN cord-010119-t1x9gknd 12396 31 one one CD cord-010119-t1x9gknd 12396 32 product product NN cord-010119-t1x9gknd 12396 33 type type NN cord-010119-t1x9gknd 12396 34 ordered order VBN cord-010119-t1x9gknd 12396 35 on on IN cord-010119-t1x9gknd 12396 36 a a DT cord-010119-t1x9gknd 12396 37 single single JJ cord-010119-t1x9gknd 12396 38 order order NN cord-010119-t1x9gknd 12396 39 , , , cord-010119-t1x9gknd 12396 40 or or CC cord-010119-t1x9gknd 12396 41 two two CD cord-010119-t1x9gknd 12396 42 patient patient JJ cord-010119-t1x9gknd 12396 43 names name NNS cord-010119-t1x9gknd 12396 44 on on IN cord-010119-t1x9gknd 12396 45 one one CD cord-010119-t1x9gknd 12396 46 order order NN cord-010119-t1x9gknd 12396 47 . . . cord-010119-t1x9gknd 12397 1 Electronic electronic JJ cord-010119-t1x9gknd 12397 2 ordering ordering NN cord-010119-t1x9gknd 12397 3 also also RB cord-010119-t1x9gknd 12397 4 provided provide VBD cord-010119-t1x9gknd 12397 5 a a DT cord-010119-t1x9gknd 12397 6 place place NN cord-010119-t1x9gknd 12397 7 for for IN cord-010119-t1x9gknd 12397 8 the the DT cord-010119-t1x9gknd 12397 9 transfusionist transfusionist NN cord-010119-t1x9gknd 12397 10 to to TO cord-010119-t1x9gknd 12397 11 chart chart VB cord-010119-t1x9gknd 12397 12 against against IN cord-010119-t1x9gknd 12397 13 , , , cord-010119-t1x9gknd 12397 14 leading lead VBG cord-010119-t1x9gknd 12397 15 to to IN cord-010119-t1x9gknd 12397 16 increased increase VBN cord-010119-t1x9gknd 12397 17 transfusion transfusion NN cord-010119-t1x9gknd 12397 18 documentation documentation NN cord-010119-t1x9gknd 12397 19 compliance compliance NN cord-010119-t1x9gknd 12397 20 . . . cord-010119-t1x9gknd 12398 1 Prior prior RB cord-010119-t1x9gknd 12398 2 to to IN cord-010119-t1x9gknd 12398 3 electronic electronic JJ cord-010119-t1x9gknd 12398 4 order order NN cord-010119-t1x9gknd 12398 5 implementation implementation NN cord-010119-t1x9gknd 12398 6 , , , cord-010119-t1x9gknd 12398 7 in in IN cord-010119-t1x9gknd 12398 8 2013 2013 CD cord-010119-t1x9gknd 12398 9 , , , cord-010119-t1x9gknd 12398 10 17/651 17/651 CD cord-010119-t1x9gknd 12398 11 ( ( -LRB- cord-010119-t1x9gknd 12399 1 2.61 2.61 CD cord-010119-t1x9gknd 12399 2 % % NN cord-010119-t1x9gknd 12399 3 ) ) -RRB- cord-010119-t1x9gknd 12399 4 units unit NNS cord-010119-t1x9gknd 12399 5 were be VBD cord-010119-t1x9gknd 12399 6 transfused transfuse VBN cord-010119-t1x9gknd 12399 7 in in IN cord-010119-t1x9gknd 12399 8 the the DT cord-010119-t1x9gknd 12399 9 ED ED NNP cord-010119-t1x9gknd 12399 10 but but CC cord-010119-t1x9gknd 12399 11 not not RB cord-010119-t1x9gknd 12399 12 charted chart VBN cord-010119-t1x9gknd 12399 13 in in IN cord-010119-t1x9gknd 12399 14 the the DT cord-010119-t1x9gknd 12399 15 patient patient NN cord-010119-t1x9gknd 12399 16 's 's POS cord-010119-t1x9gknd 12399 17 medical medical JJ cord-010119-t1x9gknd 12399 18 record record NN cord-010119-t1x9gknd 12399 19 . . . cord-010119-t1x9gknd 12400 1 In in IN cord-010119-t1x9gknd 12400 2 2014 2014 CD cord-010119-t1x9gknd 12400 3 , , , cord-010119-t1x9gknd 12400 4 18/536 18/536 CD cord-010119-t1x9gknd 12400 5 ( ( -LRB- cord-010119-t1x9gknd 12400 6 3.36 3.36 CD cord-010119-t1x9gknd 12400 7 % % NN cord-010119-t1x9gknd 12400 8 ) ) -RRB- cord-010119-t1x9gknd 12400 9 transfusions transfusion NNS cord-010119-t1x9gknd 12400 10 were be VBD cord-010119-t1x9gknd 12400 11 not not RB cord-010119-t1x9gknd 12400 12 charted chart VBN cord-010119-t1x9gknd 12400 13 . . . cord-010119-t1x9gknd 12401 1 However however RB cord-010119-t1x9gknd 12401 2 , , , cord-010119-t1x9gknd 12401 3 in in IN cord-010119-t1x9gknd 12401 4 2016 2016 CD cord-010119-t1x9gknd 12401 5 , , , cord-010119-t1x9gknd 12401 6 the the DT cord-010119-t1x9gknd 12401 7 first first JJ cord-010119-t1x9gknd 12401 8 full full JJ cord-010119-t1x9gknd 12401 9 year year NN cord-010119-t1x9gknd 12401 10 of of IN cord-010119-t1x9gknd 12401 11 electronic electronic JJ cord-010119-t1x9gknd 12401 12 transfusion transfusion NN cord-010119-t1x9gknd 12401 13 order order NN cord-010119-t1x9gknd 12401 14 capability capability NN cord-010119-t1x9gknd 12401 15 , , , cord-010119-t1x9gknd 12401 16 only only RB cord-010119-t1x9gknd 12401 17 4/462 4/462 CD cord-010119-t1x9gknd 12401 18 ( ( -LRB- cord-010119-t1x9gknd 12401 19 0.87 0.87 CD cord-010119-t1x9gknd 12401 20 % % NN cord-010119-t1x9gknd 12401 21 ) ) -RRB- cord-010119-t1x9gknd 12401 22 transfusions transfusion NNS cord-010119-t1x9gknd 12401 23 were be VBD cord-010119-t1x9gknd 12401 24 not not RB cord-010119-t1x9gknd 12401 25 charted chart VBN cord-010119-t1x9gknd 12401 26 in in IN cord-010119-t1x9gknd 12401 27 the the DT cord-010119-t1x9gknd 12401 28 patient patient NN cord-010119-t1x9gknd 12401 29 's 's POS cord-010119-t1x9gknd 12401 30 medical medical JJ cord-010119-t1x9gknd 12401 31 record record NN cord-010119-t1x9gknd 12401 32 . . . cord-010119-t1x9gknd 12402 1 Conclusion conclusion NN cord-010119-t1x9gknd 12402 2 : : : cord-010119-t1x9gknd 12402 3 Electronic electronic JJ cord-010119-t1x9gknd 12402 4 ordering ordering NN cord-010119-t1x9gknd 12402 5 in in IN cord-010119-t1x9gknd 12402 6 the the DT cord-010119-t1x9gknd 12402 7 ED ED NNP cord-010119-t1x9gknd 12402 8 has have VBZ cord-010119-t1x9gknd 12402 9 essentially essentially RB cord-010119-t1x9gknd 12402 10 eliminated eliminate VBN cord-010119-t1x9gknd 12402 11 ordering order VBG cord-010119-t1x9gknd 12402 12 errors error NNS cord-010119-t1x9gknd 12402 13 in in IN cord-010119-t1x9gknd 12402 14 this this DT cord-010119-t1x9gknd 12402 15 area area NN cord-010119-t1x9gknd 12402 16 resulting result VBG cord-010119-t1x9gknd 12402 17 in in IN cord-010119-t1x9gknd 12402 18 less less JJR cord-010119-t1x9gknd 12402 19 rework rework NN cord-010119-t1x9gknd 12402 20 for for IN cord-010119-t1x9gknd 12402 21 both both DT cord-010119-t1x9gknd 12402 22 technologists technologist NNS cord-010119-t1x9gknd 12402 23 and and CC cord-010119-t1x9gknd 12402 24 physicians physician NNS cord-010119-t1x9gknd 12402 25 . . . cord-010119-t1x9gknd 12403 1 It -PRON- PRP cord-010119-t1x9gknd 12403 2 allowed allow VBD cord-010119-t1x9gknd 12403 3 the the DT cord-010119-t1x9gknd 12403 4 order order NN cord-010119-t1x9gknd 12403 5 to to TO cord-010119-t1x9gknd 12403 6 be be VB cord-010119-t1x9gknd 12403 7 processed process VBN cord-010119-t1x9gknd 12403 8 more more RBR cord-010119-t1x9gknd 12403 9 quickly quickly RB cord-010119-t1x9gknd 12403 10 by by IN cord-010119-t1x9gknd 12403 11 TL TL NNP cord-010119-t1x9gknd 12403 12 , , , cord-010119-t1x9gknd 12403 13 resulting result VBG cord-010119-t1x9gknd 12403 14 in in IN cord-010119-t1x9gknd 12403 15 a a DT cord-010119-t1x9gknd 12403 16 faster fast JJR cord-010119-t1x9gknd 12403 17 turnaround turnaround NN cord-010119-t1x9gknd 12403 18 time time NN cord-010119-t1x9gknd 12403 19 . . . cord-010119-t1x9gknd 12404 1 Improvement improvement NN cord-010119-t1x9gknd 12404 2 in in IN cord-010119-t1x9gknd 12404 3 the the DT cord-010119-t1x9gknd 12404 4 overall overall JJ cord-010119-t1x9gknd 12404 5 quality quality NN cord-010119-t1x9gknd 12404 6 of of IN cord-010119-t1x9gknd 12404 7 transfusion transfusion NN cord-010119-t1x9gknd 12404 8 ordering order VBG cord-010119-t1x9gknd 12404 9 through through IN cord-010119-t1x9gknd 12404 10 electronic electronic JJ cord-010119-t1x9gknd 12404 11 ordering ordering NN cord-010119-t1x9gknd 12404 12 reduced reduce VBD cord-010119-t1x9gknd 12404 13 the the DT cord-010119-t1x9gknd 12404 14 influence influence NN cord-010119-t1x9gknd 12404 15 of of IN cord-010119-t1x9gknd 12404 16 human human JJ cord-010119-t1x9gknd 12404 17 factors factor NNS cord-010119-t1x9gknd 12404 18 in in IN cord-010119-t1x9gknd 12404 19 order order NN cord-010119-t1x9gknd 12404 20 placement placement NN cord-010119-t1x9gknd 12404 21 and and CC cord-010119-t1x9gknd 12404 22 provided provide VBD cord-010119-t1x9gknd 12404 23 an an DT cord-010119-t1x9gknd 12404 24 added add VBN cord-010119-t1x9gknd 12404 25 benefit benefit NN cord-010119-t1x9gknd 12404 26 of of IN cord-010119-t1x9gknd 12404 27 having have VBG cord-010119-t1x9gknd 12404 28 a a DT cord-010119-t1x9gknd 12404 29 specific specific JJ cord-010119-t1x9gknd 12404 30 order order NN cord-010119-t1x9gknd 12404 31 to to TO cord-010119-t1x9gknd 12404 32 chart chart VB cord-010119-t1x9gknd 12404 33 against against IN cord-010119-t1x9gknd 12404 34 . . . cord-010119-t1x9gknd 12405 1 Implementation implementation NN cord-010119-t1x9gknd 12405 2 of of IN cord-010119-t1x9gknd 12405 3 Blood Blood NNP cord-010119-t1x9gknd 12405 4 Bank Bank NNP cord-010119-t1x9gknd 12405 5 Automated Automated NNP cord-010119-t1x9gknd 12405 6 Attendant Attendant NNP cord-010119-t1x9gknd 12405 7 Lok Lok NNP cord-010119-t1x9gknd 12405 8 Tse Tse NNP cord-010119-t1x9gknd 12406 1 * * NFP cord-010119-t1x9gknd 12406 2 , , , cord-010119-t1x9gknd 12406 3 Gerald Gerald NNP cord-010119-t1x9gknd 12406 4 Motta Motta NNP cord-010119-t1x9gknd 12406 5 and and CC cord-010119-t1x9gknd 12406 6 Maria Maria NNP cord-010119-t1x9gknd 12406 7 Aguad Aguad NNP cord-010119-t1x9gknd 12406 8 . . . cord-010119-t1x9gknd 12407 1 Brigham Brigham NNP cord-010119-t1x9gknd 12407 2 and and CC cord-010119-t1x9gknd 12407 3 Women Women NNP cord-010119-t1x9gknd 12407 4 's 's POS cord-010119-t1x9gknd 12407 5 Hospital Hospital NNP cord-010119-t1x9gknd 12407 6 Background Background NNP cord-010119-t1x9gknd 12407 7 / / SYM cord-010119-t1x9gknd 12407 8 Case Case NNP cord-010119-t1x9gknd 12407 9 Studies Studies NNPS cord-010119-t1x9gknd 12407 10 : : : cord-010119-t1x9gknd 12408 1 The the DT cord-010119-t1x9gknd 12408 2 Blood Blood NNP cord-010119-t1x9gknd 12408 3 Bank Bank NNP cord-010119-t1x9gknd 12408 4 receives receive VBZ cord-010119-t1x9gknd 12408 5 numerous numerous JJ cord-010119-t1x9gknd 12408 6 nonemergent nonemergent NN cord-010119-t1x9gknd 12408 7 phone phone NN cord-010119-t1x9gknd 12408 8 calls call NNS cord-010119-t1x9gknd 12408 9 on on IN cord-010119-t1x9gknd 12408 10 a a DT cord-010119-t1x9gknd 12408 11 daily daily JJ cord-010119-t1x9gknd 12408 12 basis basis NN cord-010119-t1x9gknd 12408 13 . . . cord-010119-t1x9gknd 12409 1 These these DT cord-010119-t1x9gknd 12409 2 calls call NNS cord-010119-t1x9gknd 12409 3 not not RB cord-010119-t1x9gknd 12409 4 only only RB cord-010119-t1x9gknd 12409 5 occupied occupy VBD cord-010119-t1x9gknd 12409 6 valuable valuable JJ cord-010119-t1x9gknd 12409 7 time time NN cord-010119-t1x9gknd 12409 8 but but CC cord-010119-t1x9gknd 12409 9 also also RB cord-010119-t1x9gknd 12409 10 made make VBD cord-010119-t1x9gknd 12409 11 the the DT cord-010119-t1x9gknd 12409 12 lines line NNS cord-010119-t1x9gknd 12409 13 unavailable unavailable JJ cord-010119-t1x9gknd 12409 14 when when WRB cord-010119-t1x9gknd 12409 15 a a DT cord-010119-t1x9gknd 12409 16 real real JJ cord-010119-t1x9gknd 12409 17 emergency emergency NN cord-010119-t1x9gknd 12409 18 occurred occur VBD cord-010119-t1x9gknd 12409 19 . . . cord-010119-t1x9gknd 12410 1 The the DT cord-010119-t1x9gknd 12410 2 Hospital Hospital NNP cord-010119-t1x9gknd 12410 3 is be VBZ cord-010119-t1x9gknd 12410 4 categorized categorize VBN cord-010119-t1x9gknd 12410 5 as as IN cord-010119-t1x9gknd 12410 6 a a DT cord-010119-t1x9gknd 12410 7 Level Level NNP cord-010119-t1x9gknd 12410 8 1 1 CD cord-010119-t1x9gknd 12410 9 trauma trauma NN cord-010119-t1x9gknd 12410 10 center center NN cord-010119-t1x9gknd 12410 11 , , , cord-010119-t1x9gknd 12410 12 with with IN cord-010119-t1x9gknd 12410 13 over over IN cord-010119-t1x9gknd 12410 14 700 700 CD cord-010119-t1x9gknd 12410 15 inpatient inpatient JJ cord-010119-t1x9gknd 12410 16 beds bed NNS cord-010119-t1x9gknd 12410 17 and and CC cord-010119-t1x9gknd 12410 18 over over IN cord-010119-t1x9gknd 12410 19 50 50 CD cord-010119-t1x9gknd 12410 20 operating operating NN cord-010119-t1x9gknd 12410 21 rooms room NNS cord-010119-t1x9gknd 12410 22 . . . cord-010119-t1x9gknd 12411 1 A a DT cord-010119-t1x9gknd 12411 2 proposal proposal NN cord-010119-t1x9gknd 12411 3 to to TO cord-010119-t1x9gknd 12411 4 implement implement VB cord-010119-t1x9gknd 12411 5 a a DT cord-010119-t1x9gknd 12411 6 Blood Blood NNP cord-010119-t1x9gknd 12411 7 Bank Bank NNP cord-010119-t1x9gknd 12411 8 automated automate VBN cord-010119-t1x9gknd 12411 9 attendant attendant NN cord-010119-t1x9gknd 12411 10 was be VBD cord-010119-t1x9gknd 12411 11 recommended recommend VBN cord-010119-t1x9gknd 12411 12 to to TO cord-010119-t1x9gknd 12411 13 decrease decrease VB cord-010119-t1x9gknd 12411 14 phone phone NN cord-010119-t1x9gknd 12411 15 calls call NNS cord-010119-t1x9gknd 12411 16 , , , cord-010119-t1x9gknd 12411 17 minimize minimize VB cord-010119-t1x9gknd 12411 18 errors error NNS cord-010119-t1x9gknd 12411 19 due due JJ cord-010119-t1x9gknd 12411 20 to to IN cord-010119-t1x9gknd 12411 21 distraction distraction NN cord-010119-t1x9gknd 12411 22 from from IN cord-010119-t1x9gknd 12411 23 phone phone NN cord-010119-t1x9gknd 12411 24 calls call NNS cord-010119-t1x9gknd 12411 25 , , , cord-010119-t1x9gknd 12411 26 free free JJ cord-010119-t1x9gknd 12411 27 team team NN cord-010119-t1x9gknd 12411 28 members member NNS cord-010119-t1x9gknd 12411 29 to to TO cord-010119-t1x9gknd 12411 30 perform perform VB cord-010119-t1x9gknd 12411 31 other other JJ cord-010119-t1x9gknd 12411 32 duties duty NNS cord-010119-t1x9gknd 12411 33 and and CC cord-010119-t1x9gknd 12411 34 have have VBP cord-010119-t1x9gknd 12411 35 a a DT cord-010119-t1x9gknd 12411 36 direct direct JJ cord-010119-t1x9gknd 12411 37 line line NN cord-010119-t1x9gknd 12411 38 designated designate VBN cord-010119-t1x9gknd 12411 39 for for IN cord-010119-t1x9gknd 12411 40 requesting request VBG cord-010119-t1x9gknd 12411 41 trauma trauma NN cord-010119-t1x9gknd 12411 42 coolers cooler NNS cord-010119-t1x9gknd 12411 43 , , , cord-010119-t1x9gknd 12411 44 massive massive JJ cord-010119-t1x9gknd 12411 45 transfusion transfusion NN cord-010119-t1x9gknd 12411 46 protocol protocol NN cord-010119-t1x9gknd 12411 47 ( ( -LRB- cord-010119-t1x9gknd 12411 48 MTP MTP NNP cord-010119-t1x9gknd 12411 49 ) ) -RRB- cord-010119-t1x9gknd 12411 50 and and CC cord-010119-t1x9gknd 12411 51 emergency emergency NN cord-010119-t1x9gknd 12411 52 release release NN cord-010119-t1x9gknd 12411 53 of of IN cord-010119-t1x9gknd 12411 54 blood blood NN cord-010119-t1x9gknd 12411 55 products product NNS cord-010119-t1x9gknd 12411 56 . . . cord-010119-t1x9gknd 12412 1 Study Study NNP cord-010119-t1x9gknd 12412 2 Design Design NNP cord-010119-t1x9gknd 12412 3 / / SYM cord-010119-t1x9gknd 12412 4 Method method NN cord-010119-t1x9gknd 12412 5 : : : cord-010119-t1x9gknd 12412 6 The the DT cord-010119-t1x9gknd 12412 7 first first JJ cord-010119-t1x9gknd 12412 8 step step NN cord-010119-t1x9gknd 12412 9 was be VBD cord-010119-t1x9gknd 12412 10 to to TO cord-010119-t1x9gknd 12412 11 categorize categorize VB cord-010119-t1x9gknd 12412 12 the the DT cord-010119-t1x9gknd 12412 13 types type NNS cord-010119-t1x9gknd 12412 14 of of IN cord-010119-t1x9gknd 12412 15 phone phone NN cord-010119-t1x9gknd 12412 16 calls call NNS cord-010119-t1x9gknd 12412 17 received receive VBN cord-010119-t1x9gknd 12412 18 by by IN cord-010119-t1x9gknd 12412 19 the the DT cord-010119-t1x9gknd 12412 20 Blood Blood NNP cord-010119-t1x9gknd 12412 21 Bank Bank NNP cord-010119-t1x9gknd 12412 22 by by IN cord-010119-t1x9gknd 12412 23 creating create VBG cord-010119-t1x9gknd 12412 24 a a DT cord-010119-t1x9gknd 12412 25 phone phone NN cord-010119-t1x9gknd 12412 26 log log NN cord-010119-t1x9gknd 12412 27 . . . cord-010119-t1x9gknd 12413 1 Data datum NNS cord-010119-t1x9gknd 12413 2 were be VBD cord-010119-t1x9gknd 12413 3 collected collect VBN cord-010119-t1x9gknd 12413 4 and and CC cord-010119-t1x9gknd 12413 5 analyzed analyze VBN cord-010119-t1x9gknd 12413 6 for for IN cord-010119-t1x9gknd 12413 7 four four CD cord-010119-t1x9gknd 12413 8 weeks week NNS cord-010119-t1x9gknd 12413 9 . . . cord-010119-t1x9gknd 12414 1 The the DT cord-010119-t1x9gknd 12414 2 blood blood NN cord-010119-t1x9gknd 12414 3 bank bank NN cord-010119-t1x9gknd 12414 4 collaborated collaborate VBN cord-010119-t1x9gknd 12414 5 with with IN cord-010119-t1x9gknd 12414 6 nursing nursing NN cord-010119-t1x9gknd 12414 7 , , , cord-010119-t1x9gknd 12414 8 hospital hospital NN cord-010119-t1x9gknd 12414 9 administrative administrative JJ cord-010119-t1x9gknd 12414 10 staff staff NN cord-010119-t1x9gknd 12414 11 and and CC cord-010119-t1x9gknd 12414 12 telecommunication telecommunication NN cord-010119-t1x9gknd 12414 13 team team NN cord-010119-t1x9gknd 12414 14 to to TO cord-010119-t1x9gknd 12414 15 evaluate evaluate VB cord-010119-t1x9gknd 12414 16 the the DT cord-010119-t1x9gknd 12414 17 possibility possibility NN cord-010119-t1x9gknd 12414 18 of of IN cord-010119-t1x9gknd 12414 19 implementing implement VBG cord-010119-t1x9gknd 12414 20 an an DT cord-010119-t1x9gknd 12414 21 automated automate VBN cord-010119-t1x9gknd 12414 22 attendant attendant NN cord-010119-t1x9gknd 12414 23 to to TO cord-010119-t1x9gknd 12414 24 minimize minimize VB cord-010119-t1x9gknd 12414 25 phone phone NN cord-010119-t1x9gknd 12414 26 calls call NNS cord-010119-t1x9gknd 12414 27 . . . cord-010119-t1x9gknd 12415 1 It -PRON- PRP cord-010119-t1x9gknd 12415 2 was be VBD cord-010119-t1x9gknd 12415 3 very very RB cord-010119-t1x9gknd 12415 4 important important JJ cord-010119-t1x9gknd 12415 5 to to TO cord-010119-t1x9gknd 12415 6 maintain maintain VB cord-010119-t1x9gknd 12415 7 patient patient JJ cord-010119-t1x9gknd 12415 8 safety safety NN cord-010119-t1x9gknd 12415 9 and and CC cord-010119-t1x9gknd 12415 10 quality quality NN cord-010119-t1x9gknd 12415 11 of of IN cord-010119-t1x9gknd 12415 12 service service NN cord-010119-t1x9gknd 12415 13 at at IN cord-010119-t1x9gknd 12415 14 the the DT cord-010119-t1x9gknd 12415 15 same same JJ cord-010119-t1x9gknd 12415 16 time time NN cord-010119-t1x9gknd 12415 17 . . . cord-010119-t1x9gknd 12416 1 The the DT cord-010119-t1x9gknd 12416 2 automated automate VBN cord-010119-t1x9gknd 12416 3 attendant attendant NN cord-010119-t1x9gknd 12416 4 consist consist VBP cord-010119-t1x9gknd 12416 5 of of IN cord-010119-t1x9gknd 12416 6 : : : cord-010119-t1x9gknd 12416 7 Option option NN cord-010119-t1x9gknd 12416 8 1 1 CD cord-010119-t1x9gknd 12416 9 ( ( -LRB- cord-010119-t1x9gknd 12416 10 Urgent Urgent NNP cord-010119-t1x9gknd 12416 11 ) ) -RRB- cord-010119-t1x9gknd 12416 12 for for IN cord-010119-t1x9gknd 12416 13 trauma trauma NN cord-010119-t1x9gknd 12416 14 , , , cord-010119-t1x9gknd 12416 15 emergency emergency NN cord-010119-t1x9gknd 12416 16 release release NN cord-010119-t1x9gknd 12416 17 , , , cord-010119-t1x9gknd 12416 18 MTP MTP NNP cord-010119-t1x9gknd 12416 19 and and CC cord-010119-t1x9gknd 12416 20 obstetric obstetric JJ cord-010119-t1x9gknd 12416 21 hemorrhage hemorrhage NN cord-010119-t1x9gknd 12416 22 emergency emergency NN cord-010119-t1x9gknd 12416 23 release release NN cord-010119-t1x9gknd 12416 24 ; ; : cord-010119-t1x9gknd 12416 25 Option option NN cord-010119-t1x9gknd 12416 26 2 2 CD cord-010119-t1x9gknd 12416 27 ( ( -LRB- cord-010119-t1x9gknd 12416 28 Verbal Verbal NNP cord-010119-t1x9gknd 12416 29 ) ) -RRB- cord-010119-t1x9gknd 12416 30 for for IN cord-010119-t1x9gknd 12416 31 verbal verbal JJ cord-010119-t1x9gknd 12416 32 orders order NNS cord-010119-t1x9gknd 12416 33 and and CC cord-010119-t1x9gknd 12416 34 coolers cooler NNS cord-010119-t1x9gknd 12416 35 set set VBN cord-010119-t1x9gknd 12416 36 up up RP cord-010119-t1x9gknd 12416 37 ; ; : cord-010119-t1x9gknd 12416 38 and and CC cord-010119-t1x9gknd 12416 39 Option option NN cord-010119-t1x9gknd 12416 40 3 3 CD cord-010119-t1x9gknd 12416 41 ( ( -LRB- cord-010119-t1x9gknd 12416 42 Staff staff NN cord-010119-t1x9gknd 12416 43 ) ) -RRB- cord-010119-t1x9gknd 12416 44 to to TO cord-010119-t1x9gknd 12416 45 speak speak VB cord-010119-t1x9gknd 12416 46 with with IN cord-010119-t1x9gknd 12416 47 staff staff NN cord-010119-t1x9gknd 12416 48 member member NN cord-010119-t1x9gknd 12416 49 . . . cord-010119-t1x9gknd 12417 1 Instructions instruction NNS cord-010119-t1x9gknd 12417 2 were be VBD cord-010119-t1x9gknd 12417 3 also also RB cord-010119-t1x9gknd 12417 4 given give VBN cord-010119-t1x9gknd 12417 5 for for IN cord-010119-t1x9gknd 12417 6 specimen specimen JJ cord-010119-t1x9gknd 12417 7 inquiry inquiry NN cord-010119-t1x9gknd 12417 8 and and CC cord-010119-t1x9gknd 12417 9 product product NN cord-010119-t1x9gknd 12417 10 availability availability NN cord-010119-t1x9gknd 12417 11 in in IN cord-010119-t1x9gknd 12417 12 the the DT cord-010119-t1x9gknd 12417 13 hospital hospital NN cord-010119-t1x9gknd 12417 14 information information NN cord-010119-t1x9gknd 12417 15 system system NN cord-010119-t1x9gknd 12417 16 . . . cord-010119-t1x9gknd 12418 1 Results/ Results/ . cord-010119-t1x9gknd 12419 1 Finding find VBG cord-010119-t1x9gknd 12420 1 : : : cord-010119-t1x9gknd 12420 2 The the DT cord-010119-t1x9gknd 12420 3 data datum NNS cord-010119-t1x9gknd 12420 4 in in IN cord-010119-t1x9gknd 12420 5 Table table NN cord-010119-t1x9gknd 12420 6 1 1 CD cord-010119-t1x9gknd 12420 7 showed show VBD cord-010119-t1x9gknd 12420 8 that that IN cord-010119-t1x9gknd 12420 9 most most JJS cord-010119-t1x9gknd 12420 10 of of IN cord-010119-t1x9gknd 12420 11 the the DT cord-010119-t1x9gknd 12420 12 incoming incoming JJ cord-010119-t1x9gknd 12420 13 calls call NNS cord-010119-t1x9gknd 12420 14 fall fall VBP cord-010119-t1x9gknd 12420 15 into into IN cord-010119-t1x9gknd 12420 16 three three CD cord-010119-t1x9gknd 12420 17 categories category NNS cord-010119-t1x9gknd 12420 18 ( ( -LRB- cord-010119-t1x9gknd 12420 19 specimen specimen JJ cord-010119-t1x9gknd 12420 20 inquiries inquiry NNS cord-010119-t1x9gknd 12420 21 , , , cord-010119-t1x9gknd 12420 22 product product NN cord-010119-t1x9gknd 12420 23 order order NN cord-010119-t1x9gknd 12420 24 inquiries inquiry NNS cord-010119-t1x9gknd 12420 25 , , , cord-010119-t1x9gknd 12420 26 and and CC cord-010119-t1x9gknd 12420 27 other other JJ cord-010119-t1x9gknd 12420 28 inquiries inquiry NNS cord-010119-t1x9gknd 12420 29 ) ) -RRB- cord-010119-t1x9gknd 12420 30 . . . cord-010119-t1x9gknd 12421 1 Most Most JJS cord-010119-t1x9gknd 12421 2 of of IN cord-010119-t1x9gknd 12421 3 the the DT cord-010119-t1x9gknd 12421 4 calls call NNS cord-010119-t1x9gknd 12421 5 were be VBD cord-010119-t1x9gknd 12421 6 from from IN cord-010119-t1x9gknd 12421 7 nursing nursing NN cord-010119-t1x9gknd 12421 8 staff staff NN cord-010119-t1x9gknd 12421 9 inquiring inquire VBG cord-010119-t1x9gknd 12421 10 about about IN cord-010119-t1x9gknd 12421 11 the the DT cord-010119-t1x9gknd 12421 12 length length NN cord-010119-t1x9gknd 12421 13 of of IN cord-010119-t1x9gknd 12421 14 wait wait NN cord-010119-t1x9gknd 12421 15 time time NN cord-010119-t1x9gknd 12421 16 for for IN cord-010119-t1x9gknd 12421 17 blood blood NN cord-010119-t1x9gknd 12421 18 products product NNS cord-010119-t1x9gknd 12421 19 and and CC cord-010119-t1x9gknd 12421 20 specimen specimen JJ cord-010119-t1x9gknd 12421 21 availability availability NN cord-010119-t1x9gknd 12421 22 . . . cord-010119-t1x9gknd 12422 1 There there EX cord-010119-t1x9gknd 12422 2 was be VBD cord-010119-t1x9gknd 12422 3 an an DT cord-010119-t1x9gknd 12422 4 overall overall JJ cord-010119-t1x9gknd 12422 5 decrease decrease NN cord-010119-t1x9gknd 12422 6 in in IN cord-010119-t1x9gknd 12422 7 phone phone NN cord-010119-t1x9gknd 12422 8 calls call NNS cord-010119-t1x9gknd 12422 9 by by IN cord-010119-t1x9gknd 12422 10 68 68 CD cord-010119-t1x9gknd 12422 11 % % NN cord-010119-t1x9gknd 12422 12 with with IN cord-010119-t1x9gknd 12422 13 the the DT cord-010119-t1x9gknd 12422 14 implementation implementation NN cord-010119-t1x9gknd 12422 15 of of IN cord-010119-t1x9gknd 12422 16 an an DT cord-010119-t1x9gknd 12422 17 automated automate VBN cord-010119-t1x9gknd 12422 18 attendant attendant NN cord-010119-t1x9gknd 12422 19 . . . cord-010119-t1x9gknd 12423 1 Conclusion conclusion NN cord-010119-t1x9gknd 12423 2 : : : cord-010119-t1x9gknd 12423 3 With with IN cord-010119-t1x9gknd 12423 4 the the DT cord-010119-t1x9gknd 12423 5 implementation implementation NN cord-010119-t1x9gknd 12423 6 of of IN cord-010119-t1x9gknd 12423 7 an an DT cord-010119-t1x9gknd 12423 8 automated automate VBN cord-010119-t1x9gknd 12423 9 attendant attendant NN cord-010119-t1x9gknd 12423 10 , , , cord-010119-t1x9gknd 12423 11 the the DT cord-010119-t1x9gknd 12423 12 blood blood NN cord-010119-t1x9gknd 12423 13 bank bank NN cord-010119-t1x9gknd 12423 14 team team NN cord-010119-t1x9gknd 12423 15 was be VBD cord-010119-t1x9gknd 12423 16 able able JJ cord-010119-t1x9gknd 12423 17 to to TO cord-010119-t1x9gknd 12423 18 identify identify VB cord-010119-t1x9gknd 12423 19 and and CC cord-010119-t1x9gknd 12423 20 respond respond VB cord-010119-t1x9gknd 12423 21 accordingly accordingly RB cord-010119-t1x9gknd 12423 22 and and CC cord-010119-t1x9gknd 12423 23 efficiently efficiently RB cord-010119-t1x9gknd 12423 24 to to IN cord-010119-t1x9gknd 12423 25 urgent urgent JJ cord-010119-t1x9gknd 12423 26 requests request NNS cord-010119-t1x9gknd 12423 27 and and CC cord-010119-t1x9gknd 12423 28 verbal verbal JJ cord-010119-t1x9gknd 12423 29 phone phone NN cord-010119-t1x9gknd 12423 30 orders order NNS cord-010119-t1x9gknd 12423 31 . . . cord-010119-t1x9gknd 12424 1 The the DT cord-010119-t1x9gknd 12424 2 decrease decrease NN cord-010119-t1x9gknd 12424 3 in in IN cord-010119-t1x9gknd 12424 4 phone phone NN cord-010119-t1x9gknd 12424 5 calls call NNS cord-010119-t1x9gknd 12424 6 freed free VBN cord-010119-t1x9gknd 12424 7 up up RP cord-010119-t1x9gknd 12424 8 team team NN cord-010119-t1x9gknd 12424 9 members member NNS cord-010119-t1x9gknd 12424 10 to to TO cord-010119-t1x9gknd 12424 11 perform perform VB cord-010119-t1x9gknd 12424 12 other other JJ cord-010119-t1x9gknd 12424 13 critical critical JJ cord-010119-t1x9gknd 12424 14 tasks task NNS cord-010119-t1x9gknd 12424 15 in in IN cord-010119-t1x9gknd 12424 16 the the DT cord-010119-t1x9gknd 12424 17 department department NN cord-010119-t1x9gknd 12424 18 . . . cord-010119-t1x9gknd 12425 1 Improved Improved NNP cord-010119-t1x9gknd 12425 2 Detection Detection NNP cord-010119-t1x9gknd 12425 3 of of IN cord-010119-t1x9gknd 12425 4 Wrong wrong JJ cord-010119-t1x9gknd 12425 5 Blood blood NN cord-010119-t1x9gknd 12425 6 in in IN cord-010119-t1x9gknd 12425 7 Tube tube NN cord-010119-t1x9gknd 12425 8 Errors error NNS cord-010119-t1x9gknd 12425 9 : : : cord-010119-t1x9gknd 12425 10 Implementation implementation NN cord-010119-t1x9gknd 12425 11 of of IN cord-010119-t1x9gknd 12425 12 a a DT cord-010119-t1x9gknd 12425 13 Two two CD cord-010119-t1x9gknd 12425 14 - - HYPH cord-010119-t1x9gknd 12425 15 Sample sample NN cord-010119-t1x9gknd 12425 16 Blood blood NN cord-010119-t1x9gknd 12425 17 Type type NN cord-010119-t1x9gknd 12425 18 Verification verification NN cord-010119-t1x9gknd 12425 19 Process Process NNP cord-010119-t1x9gknd 12425 20 Ariana Ariana NNP cord-010119-t1x9gknd 12425 21 King King NNP cord-010119-t1x9gknd 12425 22 * * NFP cord-010119-t1x9gknd 12425 23 1 1 CD cord-010119-t1x9gknd 12425 24 , , , cord-010119-t1x9gknd 12425 25 Steven Steven NNP cord-010119-t1x9gknd 12425 26 Zibrat Zibrat NNP cord-010119-t1x9gknd 12425 27 1 1 CD cord-010119-t1x9gknd 12425 28 , , , cord-010119-t1x9gknd 12425 29 Geoffrey Geoffrey NNP cord-010119-t1x9gknd 12425 30 Wool Wool NNP cord-010119-t1x9gknd 12425 31 2 2 CD cord-010119-t1x9gknd 12425 32 and and CC cord-010119-t1x9gknd 12425 33 Angela Angela NNP cord-010119-t1x9gknd 12425 34 Treml Treml NNP cord-010119-t1x9gknd 12425 35 2 2 CD cord-010119-t1x9gknd 12425 36 . . . cord-010119-t1x9gknd 12426 1 1 1 CD cord-010119-t1x9gknd 12426 2 University University NNP cord-010119-t1x9gknd 12426 3 of of IN cord-010119-t1x9gknd 12426 4 Chicago Chicago NNP cord-010119-t1x9gknd 12426 5 Medicine Medicine NNP cord-010119-t1x9gknd 12426 6 , , , cord-010119-t1x9gknd 12426 7 2 2 CD cord-010119-t1x9gknd 12426 8 University University NNP cord-010119-t1x9gknd 12426 9 of of IN cord-010119-t1x9gknd 12426 10 Chicago Chicago NNP cord-010119-t1x9gknd 12426 11 Background Background NNP cord-010119-t1x9gknd 12426 12 / / SYM cord-010119-t1x9gknd 12426 13 Case Case NNP cord-010119-t1x9gknd 12426 14 Studies Studies NNPS cord-010119-t1x9gknd 12426 15 : : : cord-010119-t1x9gknd 12427 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12427 2 organization organization NN cord-010119-t1x9gknd 12427 3 used use VBD cord-010119-t1x9gknd 12427 4 a a DT cord-010119-t1x9gknd 12427 5 blood blood NN cord-010119-t1x9gknd 12427 6 bank bank NN cord-010119-t1x9gknd 12427 7 identification identification NN cord-010119-t1x9gknd 12427 8 ( ( -LRB- cord-010119-t1x9gknd 12427 9 BBID BBID NNP cord-010119-t1x9gknd 12427 10 ) ) -RRB- cord-010119-t1x9gknd 12427 11 band band NN cord-010119-t1x9gknd 12427 12 system system NN cord-010119-t1x9gknd 12427 13 for for IN cord-010119-t1x9gknd 12427 14 pre pre JJ cord-010119-t1x9gknd 12427 15 - - JJ cord-010119-t1x9gknd 12427 16 transfusion transfusion JJ cord-010119-t1x9gknd 12427 17 testing testing NN cord-010119-t1x9gknd 12427 18 and and CC cord-010119-t1x9gknd 12427 19 detection detection NN cord-010119-t1x9gknd 12427 20 of of IN cord-010119-t1x9gknd 12427 21 Wrong wrong JJ cord-010119-t1x9gknd 12427 22 Blood blood NN cord-010119-t1x9gknd 12427 23 in in IN cord-010119-t1x9gknd 12427 24 Tube tube NN cord-010119-t1x9gknd 12427 25 Errors error NNS cord-010119-t1x9gknd 12427 26 ( ( -LRB- cord-010119-t1x9gknd 12427 27 WBIT WBIT NNP cord-010119-t1x9gknd 12427 28 ) ) -RRB- cord-010119-t1x9gknd 12427 29 . . . cord-010119-t1x9gknd 12428 1 Additionally additionally RB cord-010119-t1x9gknd 12428 2 , , , cord-010119-t1x9gknd 12428 3 type type NN cord-010119-t1x9gknd 12428 4 & & CC cord-010119-t1x9gknd 12428 5 screen screen NN cord-010119-t1x9gknd 12428 6 results result NNS cord-010119-t1x9gknd 12428 7 were be VBD cord-010119-t1x9gknd 12428 8 compared compare VBN cord-010119-t1x9gknd 12428 9 to to IN cord-010119-t1x9gknd 12428 10 patient patient NN cord-010119-t1x9gknd 12428 11 's 's POS cord-010119-t1x9gknd 12428 12 historical historical JJ cord-010119-t1x9gknd 12428 13 records record NNS cord-010119-t1x9gknd 12428 14 ; ; : cord-010119-t1x9gknd 12428 15 the the DT cord-010119-t1x9gknd 12428 16 specimen specimen NN cord-010119-t1x9gknd 12428 17 was be VBD cord-010119-t1x9gknd 12428 18 retyped retype VBN cord-010119-t1x9gknd 12428 19 by by IN cord-010119-t1x9gknd 12428 20 a a DT cord-010119-t1x9gknd 12428 21 second second JJ cord-010119-t1x9gknd 12428 22 technologist technologist NN cord-010119-t1x9gknd 12428 23 if if IN cord-010119-t1x9gknd 12428 24 historical historical JJ cord-010119-t1x9gknd 12428 25 results result NNS cord-010119-t1x9gknd 12428 26 were be VBD cord-010119-t1x9gknd 12428 27 not not RB cord-010119-t1x9gknd 12428 28 available available JJ cord-010119-t1x9gknd 12428 29 . . . cord-010119-t1x9gknd 12429 1 The the DT cord-010119-t1x9gknd 12429 2 BBID BBID NNS cord-010119-t1x9gknd 12429 3 bands band NNS cord-010119-t1x9gknd 12429 4 were be VBD cord-010119-t1x9gknd 12429 5 prone prone JJ cord-010119-t1x9gknd 12429 6 to to IN cord-010119-t1x9gknd 12429 7 clerical clerical JJ cord-010119-t1x9gknd 12429 8 errors error NNS cord-010119-t1x9gknd 12429 9 and and CC cord-010119-t1x9gknd 12429 10 excessive excessive JJ cord-010119-t1x9gknd 12429 11 specimen specimen JJ cord-010119-t1x9gknd 12429 12 rejections rejection NNS cord-010119-t1x9gknd 12429 13 , , , cord-010119-t1x9gknd 12429 14 and and CC cord-010119-t1x9gknd 12429 15 believed believe VBD cord-010119-t1x9gknd 12429 16 to to TO cord-010119-t1x9gknd 12429 17 miss miss VB cord-010119-t1x9gknd 12429 18 some some DT cord-010119-t1x9gknd 12429 19 WBIT WBIT NNP cord-010119-t1x9gknd 12429 20 errors error NNS cord-010119-t1x9gknd 12429 21 . . . cord-010119-t1x9gknd 12430 1 In in IN cord-010119-t1x9gknd 12430 2 2015 2015 CD cord-010119-t1x9gknd 12430 3 , , , cord-010119-t1x9gknd 12430 4 Blood Blood NNP cord-010119-t1x9gknd 12430 5 Bank Bank NNP cord-010119-t1x9gknd 12430 6 accounted account VBD cord-010119-t1x9gknd 12430 7 for for IN cord-010119-t1x9gknd 12430 8 48 48 CD cord-010119-t1x9gknd 12430 9 % % NN cord-010119-t1x9gknd 12430 10 of of IN cord-010119-t1x9gknd 12430 11 all all DT cord-010119-t1x9gknd 12430 12 rejected reject VBN cord-010119-t1x9gknd 12430 13 clinical clinical JJ cord-010119-t1x9gknd 12430 14 laboratory laboratory NN cord-010119-t1x9gknd 12430 15 samples sample NNS cord-010119-t1x9gknd 12430 16 , , , cord-010119-t1x9gknd 12430 17 yet yet CC cord-010119-t1x9gknd 12430 18 comprised comprise VBN cord-010119-t1x9gknd 12430 19 only only RB cord-010119-t1x9gknd 12430 20 5 5 CD cord-010119-t1x9gknd 12430 21 % % NN cord-010119-t1x9gknd 12430 22 of of IN cord-010119-t1x9gknd 12430 23 total total JJ cord-010119-t1x9gknd 12430 24 laboratory laboratory NN cord-010119-t1x9gknd 12430 25 volume volume NN cord-010119-t1x9gknd 12430 26 ; ; : cord-010119-t1x9gknd 12430 27 88 88 CD cord-010119-t1x9gknd 12430 28 % % NN cord-010119-t1x9gknd 12430 29 of of IN cord-010119-t1x9gknd 12430 30 rejected reject VBN cord-010119-t1x9gknd 12430 31 Blood Blood NNP cord-010119-t1x9gknd 12430 32 Bank Bank NNP cord-010119-t1x9gknd 12430 33 samples sample NNS cord-010119-t1x9gknd 12430 34 were be VBD cord-010119-t1x9gknd 12430 35 due due JJ cord-010119-t1x9gknd 12430 36 to to IN cord-010119-t1x9gknd 12430 37 BBID BBID NNP cord-010119-t1x9gknd 12430 38 band band NN cord-010119-t1x9gknd 12430 39 issues issue NNS cord-010119-t1x9gknd 12430 40 . . . cord-010119-t1x9gknd 12431 1 The the DT cord-010119-t1x9gknd 12431 2 WBIT WBIT NNP cord-010119-t1x9gknd 12431 3 error error NN cord-010119-t1x9gknd 12431 4 rate rate NN cord-010119-t1x9gknd 12431 5 detected detect VBN cord-010119-t1x9gknd 12431 6 by by IN cord-010119-t1x9gknd 12431 7 BBID BBID NNP cord-010119-t1x9gknd 12431 8 - - HYPH cord-010119-t1x9gknd 12431 9 based base VBN cord-010119-t1x9gknd 12431 10 system system NN cord-010119-t1x9gknd 12431 11 was be VBD cord-010119-t1x9gknd 12431 12 0.006 0.006 CD cord-010119-t1x9gknd 12431 13 % % NN cord-010119-t1x9gknd 12431 14 . . . cord-010119-t1x9gknd 12432 1 Study Study NNP cord-010119-t1x9gknd 12432 2 Design Design NNP cord-010119-t1x9gknd 12432 3 / / SYM cord-010119-t1x9gknd 12432 4 Method method NN cord-010119-t1x9gknd 12432 5 : : : cord-010119-t1x9gknd 12433 1 A a DT cord-010119-t1x9gknd 12433 2 multidisciplinary multidisciplinary JJ cord-010119-t1x9gknd 12433 3 workgroup workgroup NN cord-010119-t1x9gknd 12433 4 was be VBD cord-010119-t1x9gknd 12433 5 formed form VBN cord-010119-t1x9gknd 12433 6 to to TO cord-010119-t1x9gknd 12433 7 review review VB cord-010119-t1x9gknd 12433 8 data datum NNS cord-010119-t1x9gknd 12433 9 and and CC cord-010119-t1x9gknd 12433 10 best good JJS cord-010119-t1x9gknd 12433 11 practices practice NNS cord-010119-t1x9gknd 12433 12 . . . cord-010119-t1x9gknd 12434 1 The the DT cord-010119-t1x9gknd 12434 2 decision decision NN cord-010119-t1x9gknd 12434 3 was be VBD cord-010119-t1x9gknd 12434 4 made make VBN cord-010119-t1x9gknd 12434 5 to to TO cord-010119-t1x9gknd 12434 6 discontinue discontinue VB cord-010119-t1x9gknd 12434 7 BBID BBID NNP cord-010119-t1x9gknd 12434 8 bands band NNS cord-010119-t1x9gknd 12434 9 and and CC cord-010119-t1x9gknd 12434 10 implement implement VB cord-010119-t1x9gknd 12434 11 a a DT cord-010119-t1x9gknd 12434 12 two two CD cord-010119-t1x9gknd 12434 13 - - HYPH cord-010119-t1x9gknd 12434 14 sample sample NN cord-010119-t1x9gknd 12434 15 verification verification NN cord-010119-t1x9gknd 12434 16 process process NN cord-010119-t1x9gknd 12434 17 , , , cord-010119-t1x9gknd 12434 18 in in IN cord-010119-t1x9gknd 12434 19 keeping keep VBG cord-010119-t1x9gknd 12434 20 with with IN cord-010119-t1x9gknd 12434 21 Standards standard NNS cord-010119-t1x9gknd 12434 22 . . . cord-010119-t1x9gknd 12435 1 A a DT cord-010119-t1x9gknd 12435 2 new new JJ cord-010119-t1x9gknd 12435 3 laboratory laboratory NN cord-010119-t1x9gknd 12435 4 test test NN cord-010119-t1x9gknd 12435 5 order order NN cord-010119-t1x9gknd 12435 6 was be VBD cord-010119-t1x9gknd 12435 7 created create VBN cord-010119-t1x9gknd 12435 8 in in IN cord-010119-t1x9gknd 12435 9 the the DT cord-010119-t1x9gknd 12435 10 EMR EMR NNP cord-010119-t1x9gknd 12435 11 system system NN cord-010119-t1x9gknd 12435 12 and and CC cord-010119-t1x9gknd 12435 13 embedded embed VBN cord-010119-t1x9gknd 12435 14 into into IN cord-010119-t1x9gknd 12435 15 the the DT cord-010119-t1x9gknd 12435 16 existing exist VBG cord-010119-t1x9gknd 12435 17 T&S T&S NNP cord-010119-t1x9gknd 12435 18 order order NN cord-010119-t1x9gknd 12435 19 . . . cord-010119-t1x9gknd 12436 1 Providers provider NNS cord-010119-t1x9gknd 12436 2 are be VBP cord-010119-t1x9gknd 12436 3 prompted prompt VBN cord-010119-t1x9gknd 12436 4 to to TO cord-010119-t1x9gknd 12436 5 order order VB cord-010119-t1x9gknd 12436 6 the the DT cord-010119-t1x9gknd 12436 7 ABO ABO NNP cord-010119-t1x9gknd 12436 8 verification verification NN cord-010119-t1x9gknd 12436 9 test test NN cord-010119-t1x9gknd 12436 10 only only RB cord-010119-t1x9gknd 12436 11 when when WRB cord-010119-t1x9gknd 12436 12 no no DT cord-010119-t1x9gknd 12436 13 previous previous JJ cord-010119-t1x9gknd 12436 14 ABO ABO NNP cord-010119-t1x9gknd 12436 15 / / SYM cord-010119-t1x9gknd 12436 16 Rh Rh NNP cord-010119-t1x9gknd 12436 17 typing typing NN cord-010119-t1x9gknd 12436 18 results result NNS cord-010119-t1x9gknd 12436 19 are be VBP cord-010119-t1x9gknd 12436 20 found find VBN cord-010119-t1x9gknd 12436 21 . . . cord-010119-t1x9gknd 12437 1 Education education NN cord-010119-t1x9gknd 12437 2 was be VBD cord-010119-t1x9gknd 12437 3 provided provide VBN cord-010119-t1x9gknd 12437 4 to to IN cord-010119-t1x9gknd 12437 5 all all DT cord-010119-t1x9gknd 12437 6 clinical clinical JJ cord-010119-t1x9gknd 12437 7 staff staff NN cord-010119-t1x9gknd 12437 8 in in IN cord-010119-t1x9gknd 12437 9 the the DT cord-010119-t1x9gknd 12437 10 form form NN cord-010119-t1x9gknd 12437 11 of of IN cord-010119-t1x9gknd 12437 12 in in IN cord-010119-t1x9gknd 12437 13 - - HYPH cord-010119-t1x9gknd 12437 14 services service NNS cord-010119-t1x9gknd 12437 15 , , , cord-010119-t1x9gknd 12437 16 emails email NNS cord-010119-t1x9gknd 12437 17 , , , cord-010119-t1x9gknd 12437 18 and and CC cord-010119-t1x9gknd 12437 19 annual annual JJ cord-010119-t1x9gknd 12437 20 competencies competency NNS cord-010119-t1x9gknd 12437 21 completed complete VBN cord-010119-t1x9gknd 12437 22 electronically electronically RB cord-010119-t1x9gknd 12437 23 . . . cord-010119-t1x9gknd 12438 1 The the DT cord-010119-t1x9gknd 12438 2 new new JJ cord-010119-t1x9gknd 12438 3 process process NN cord-010119-t1x9gknd 12438 4 went go VBD cord-010119-t1x9gknd 12438 5 live live RB cord-010119-t1x9gknd 12438 6 in in IN cord-010119-t1x9gknd 12438 7 September September NNP cord-010119-t1x9gknd 12438 8 2016 2016 CD cord-010119-t1x9gknd 12438 9 . . . cord-010119-t1x9gknd 12439 1 Results result NNS cord-010119-t1x9gknd 12439 2 / / SYM cord-010119-t1x9gknd 12439 3 Finding finding NN cord-010119-t1x9gknd 12439 4 : : : cord-010119-t1x9gknd 12440 1 In in IN cord-010119-t1x9gknd 12440 2 the the DT cord-010119-t1x9gknd 12440 3 five five CD cord-010119-t1x9gknd 12440 4 months month NNS cord-010119-t1x9gknd 12440 5 following follow VBG cord-010119-t1x9gknd 12440 6 implementation implementation NN cord-010119-t1x9gknd 12440 7 , , , cord-010119-t1x9gknd 12440 8 four four CD cord-010119-t1x9gknd 12440 9 WBIT WBIT NNP cord-010119-t1x9gknd 12440 10 errors error NNS cord-010119-t1x9gknd 12440 11 were be VBD cord-010119-t1x9gknd 12440 12 detected detect VBN cord-010119-t1x9gknd 12440 13 with with IN cord-010119-t1x9gknd 12440 14 the the DT cord-010119-t1x9gknd 12440 15 second second JJ cord-010119-t1x9gknd 12440 16 sample sample NN cord-010119-t1x9gknd 12440 17 . . . cord-010119-t1x9gknd 12441 1 These these DT cord-010119-t1x9gknd 12441 2 may may MD cord-010119-t1x9gknd 12441 3 have have VB cord-010119-t1x9gknd 12441 4 been be VBN cord-010119-t1x9gknd 12441 5 missed miss VBN cord-010119-t1x9gknd 12441 6 using use VBG cord-010119-t1x9gknd 12441 7 the the DT cord-010119-t1x9gknd 12441 8 BBID BBID NNP cord-010119-t1x9gknd 12441 9 band band NN cord-010119-t1x9gknd 12441 10 system system NN cord-010119-t1x9gknd 12441 11 . . . cord-010119-t1x9gknd 12442 1 Improved improve VBN cord-010119-t1x9gknd 12442 2 detection detection NN cord-010119-t1x9gknd 12442 3 revealed reveal VBD cord-010119-t1x9gknd 12442 4 a a DT cord-010119-t1x9gknd 12442 5 WBIT WBIT NNP cord-010119-t1x9gknd 12442 6 error error NN cord-010119-t1x9gknd 12442 7 rate rate NN cord-010119-t1x9gknd 12442 8 of of IN cord-010119-t1x9gknd 12442 9 0.128 0.128 CD cord-010119-t1x9gknd 12442 10 % % NN cord-010119-t1x9gknd 12442 11 , , , cord-010119-t1x9gknd 12442 12 three three CD cord-010119-t1x9gknd 12442 13 times time NNS cord-010119-t1x9gknd 12442 14 the the DT cord-010119-t1x9gknd 12442 15 national national JJ cord-010119-t1x9gknd 12442 16 average average NN cord-010119-t1x9gknd 12442 17 of of IN cord-010119-t1x9gknd 12442 18 0.043 0.043 CD cord-010119-t1x9gknd 12442 19 % % NN cord-010119-t1x9gknd 12442 20 . . . cord-010119-t1x9gknd 12443 1 Under under IN cord-010119-t1x9gknd 12443 2 the the DT cord-010119-t1x9gknd 12443 3 new new JJ cord-010119-t1x9gknd 12443 4 system system NN cord-010119-t1x9gknd 12443 5 , , , cord-010119-t1x9gknd 12443 6 rejected reject VBD cord-010119-t1x9gknd 12443 7 Blood Blood NNP cord-010119-t1x9gknd 12443 8 Bank Bank NNP cord-010119-t1x9gknd 12443 9 samples sample NNS cord-010119-t1x9gknd 12443 10 decreased decrease VBD cord-010119-t1x9gknd 12443 11 from from IN cord-010119-t1x9gknd 12443 12 an an DT cord-010119-t1x9gknd 12443 13 average average NN cord-010119-t1x9gknd 12443 14 of of IN cord-010119-t1x9gknd 12443 15 50 50 CD cord-010119-t1x9gknd 12443 16 % % NN cord-010119-t1x9gknd 12443 17 to to IN cord-010119-t1x9gknd 12443 18 28 28 CD cord-010119-t1x9gknd 12443 19 % % NN cord-010119-t1x9gknd 12443 20 of of IN cord-010119-t1x9gknd 12443 21 all all DT cord-010119-t1x9gknd 12443 22 rejected reject VBN cord-010119-t1x9gknd 12443 23 laboratory laboratory NN cord-010119-t1x9gknd 12443 24 samples sample NNS cord-010119-t1x9gknd 12443 25 , , , cord-010119-t1x9gknd 12443 26 a a DT cord-010119-t1x9gknd 12443 27 43 43 CD cord-010119-t1x9gknd 12443 28 % % NN cord-010119-t1x9gknd 12443 29 decrease decrease NN cord-010119-t1x9gknd 12443 30 . . . cord-010119-t1x9gknd 12444 1 Implementation implementation NN cord-010119-t1x9gknd 12444 2 of of IN cord-010119-t1x9gknd 12444 3 the the DT cord-010119-t1x9gknd 12444 4 new new JJ cord-010119-t1x9gknd 12444 5 process process NN cord-010119-t1x9gknd 12444 6 produced produce VBD cord-010119-t1x9gknd 12444 7 a a DT cord-010119-t1x9gknd 12444 8 net net JJ cord-010119-t1x9gknd 12444 9 savings saving NNS cord-010119-t1x9gknd 12444 10 of of IN cord-010119-t1x9gknd 12444 11 $ $ $ cord-010119-t1x9gknd 12444 12 55.8K. 55.8k. CD cord-010119-t1x9gknd 12444 13 Conclusion conclusion NN cord-010119-t1x9gknd 12444 14 : : : cord-010119-t1x9gknd 12444 15 Replacing replace VBG cord-010119-t1x9gknd 12444 16 the the DT cord-010119-t1x9gknd 12444 17 BBID bbid JJ cord-010119-t1x9gknd 12444 18 band band NN cord-010119-t1x9gknd 12444 19 system system NN cord-010119-t1x9gknd 12444 20 with with IN cord-010119-t1x9gknd 12444 21 two two CD cord-010119-t1x9gknd 12444 22 - - HYPH cord-010119-t1x9gknd 12444 23 sample sample NN cord-010119-t1x9gknd 12444 24 verification verification NN cord-010119-t1x9gknd 12444 25 successfully successfully RB cord-010119-t1x9gknd 12444 26 improved improve VBD cord-010119-t1x9gknd 12444 27 our -PRON- PRP$ cord-010119-t1x9gknd 12444 28 ability ability NN cord-010119-t1x9gknd 12444 29 to to TO cord-010119-t1x9gknd 12444 30 detect detect VB cord-010119-t1x9gknd 12444 31 WBIT WBIT NNP cord-010119-t1x9gknd 12444 32 errors error NNS cord-010119-t1x9gknd 12444 33 among among IN cord-010119-t1x9gknd 12444 34 patients patient NNS cord-010119-t1x9gknd 12444 35 who who WP cord-010119-t1x9gknd 12444 36 lacked lack VBD cord-010119-t1x9gknd 12444 37 historical historical JJ cord-010119-t1x9gknd 12444 38 blood blood NN cord-010119-t1x9gknd 12444 39 bank bank NN cord-010119-t1x9gknd 12444 40 results result NNS cord-010119-t1x9gknd 12444 41 . . . cord-010119-t1x9gknd 12445 1 Additionally additionally RB cord-010119-t1x9gknd 12445 2 , , , cord-010119-t1x9gknd 12445 3 discontinuation discontinuation NN cord-010119-t1x9gknd 12445 4 of of IN cord-010119-t1x9gknd 12445 5 the the DT cord-010119-t1x9gknd 12445 6 BBID BBID NNP cord-010119-t1x9gknd 12445 7 system system NN cord-010119-t1x9gknd 12445 8 decreased decrease VBD cord-010119-t1x9gknd 12445 9 the the DT cord-010119-t1x9gknd 12445 10 incidence incidence NN cord-010119-t1x9gknd 12445 11 of of IN cord-010119-t1x9gknd 12445 12 clerical clerical JJ cord-010119-t1x9gknd 12445 13 errors error NNS cord-010119-t1x9gknd 12445 14 and and CC cord-010119-t1x9gknd 12445 15 unnecessary unnecessary JJ cord-010119-t1x9gknd 12445 16 specimen specimen JJ cord-010119-t1x9gknd 12445 17 rejections rejection NNS cord-010119-t1x9gknd 12445 18 , , , cord-010119-t1x9gknd 12445 19 and and CC cord-010119-t1x9gknd 12445 20 also also RB cord-010119-t1x9gknd 12445 21 saved save VBD cord-010119-t1x9gknd 12445 22 money money NN cord-010119-t1x9gknd 12445 23 for for IN cord-010119-t1x9gknd 12445 24 the the DT cord-010119-t1x9gknd 12445 25 organization organization NN cord-010119-t1x9gknd 12445 26 . . . cord-010119-t1x9gknd 12446 1 Next next JJ cord-010119-t1x9gknd 12446 2 steps step NNS cord-010119-t1x9gknd 12446 3 are be VBP cord-010119-t1x9gknd 12446 4 for for IN cord-010119-t1x9gknd 12446 5 Blood Blood NNP cord-010119-t1x9gknd 12446 6 Bank Bank NNP cord-010119-t1x9gknd 12446 7 and and CC cord-010119-t1x9gknd 12446 8 Laboratory Laboratory NNP cord-010119-t1x9gknd 12446 9 Quality Quality NNP cord-010119-t1x9gknd 12446 10 leaders leader NNS cord-010119-t1x9gknd 12446 11 to to IN cord-010119-t1x9gknd 12446 12 partner partner NN cord-010119-t1x9gknd 12446 13 with with IN cord-010119-t1x9gknd 12446 14 nursing nursing NN cord-010119-t1x9gknd 12446 15 leadership leadership NN cord-010119-t1x9gknd 12446 16 to to TO cord-010119-t1x9gknd 12446 17 drive drive VB cord-010119-t1x9gknd 12446 18 down down RP cord-010119-t1x9gknd 12446 19 WBIT WBIT NNP cord-010119-t1x9gknd 12446 20 error error NN cord-010119-t1x9gknd 12446 21 incidence incidence NN cord-010119-t1x9gknd 12446 22 . . . cord-010119-t1x9gknd 12447 1 253A 253a CD cord-010119-t1x9gknd 12447 2 addendum addendum NN cord-010119-t1x9gknd 12447 3 with with IN cord-010119-t1x9gknd 12447 4 the the DT cord-010119-t1x9gknd 12447 5 final final JJ cord-010119-t1x9gknd 12447 6 culture culture NN cord-010119-t1x9gknd 12447 7 results result NNS cord-010119-t1x9gknd 12447 8 . . . cord-010119-t1x9gknd 12448 1 We -PRON- PRP cord-010119-t1x9gknd 12448 2 used use VBD cord-010119-t1x9gknd 12448 3 a a DT cord-010119-t1x9gknd 12448 4 student student NN cord-010119-t1x9gknd 12448 5 's 's POS cord-010119-t1x9gknd 12448 6 t t NN cord-010119-t1x9gknd 12448 7 test test NN cord-010119-t1x9gknd 12448 8 to to TO cord-010119-t1x9gknd 12448 9 determine determine VB cord-010119-t1x9gknd 12448 10 whether whether IN cord-010119-t1x9gknd 12448 11 there there EX cord-010119-t1x9gknd 12448 12 was be VBD cord-010119-t1x9gknd 12448 13 a a DT cord-010119-t1x9gknd 12448 14 statistically statistically RB cord-010119-t1x9gknd 12448 15 significant significant JJ cord-010119-t1x9gknd 12448 16 difference difference NN cord-010119-t1x9gknd 12448 17 in in IN cord-010119-t1x9gknd 12448 18 the the DT cord-010119-t1x9gknd 12448 19 mean mean NN cord-010119-t1x9gknd 12448 20 TAT tat NN cord-010119-t1x9gknd 12448 21 for for IN cord-010119-t1x9gknd 12448 22 result result NN cord-010119-t1x9gknd 12448 23 addendum addendum NN cord-010119-t1x9gknd 12448 24 entry entry NN cord-010119-t1x9gknd 12448 25 in in IN cord-010119-t1x9gknd 12448 26 the the DT cord-010119-t1x9gknd 12448 27 post post JJ cord-010119-t1x9gknd 12448 28 - - JJ cord-010119-t1x9gknd 12448 29 implementation implementation JJ cord-010119-t1x9gknd 12448 30 period period NN cord-010119-t1x9gknd 12448 31 compared compare VBN cord-010119-t1x9gknd 12448 32 to to IN cord-010119-t1x9gknd 12448 33 the the DT cord-010119-t1x9gknd 12448 34 pre pre NN cord-010119-t1x9gknd 12448 35 - - JJ cord-010119-t1x9gknd 12448 36 implementation implementation JJ cord-010119-t1x9gknd 12448 37 period period NN cord-010119-t1x9gknd 12448 38 . . . cord-010119-t1x9gknd 12449 1 Results result NNS cord-010119-t1x9gknd 12449 2 / / SYM cord-010119-t1x9gknd 12449 3 Findings finding NNS cord-010119-t1x9gknd 12449 4 : : : cord-010119-t1x9gknd 12450 1 In in IN cord-010119-t1x9gknd 12450 2 the the DT cord-010119-t1x9gknd 12450 3 pre pre JJ cord-010119-t1x9gknd 12450 4 - - JJ cord-010119-t1x9gknd 12450 5 implementation implementation JJ cord-010119-t1x9gknd 12450 6 period period NN cord-010119-t1x9gknd 12450 7 , , , cord-010119-t1x9gknd 12450 8 we -PRON- PRP cord-010119-t1x9gknd 12450 9 cultured culture VBD cord-010119-t1x9gknd 12450 10 19 19 CD cord-010119-t1x9gknd 12450 11 residual residual JJ cord-010119-t1x9gknd 12450 12 products product NNS cord-010119-t1x9gknd 12450 13 for for IN cord-010119-t1x9gknd 12450 14 suspected suspect VBN cord-010119-t1x9gknd 12450 15 STR str NN cord-010119-t1x9gknd 12450 16 . . . cord-010119-t1x9gknd 12451 1 The the DT cord-010119-t1x9gknd 12451 2 TAT tat NN cord-010119-t1x9gknd 12451 3 for for IN cord-010119-t1x9gknd 12451 4 final final JJ cord-010119-t1x9gknd 12451 5 culture culture NN cord-010119-t1x9gknd 12451 6 result result NN cord-010119-t1x9gknd 12451 7 entry entry NN cord-010119-t1x9gknd 12451 8 into into IN cord-010119-t1x9gknd 12451 9 the the DT cord-010119-t1x9gknd 12451 10 patient patient NN cord-010119-t1x9gknd 12451 11 's 's POS cord-010119-t1x9gknd 12451 12 EMR EMR NNP cord-010119-t1x9gknd 12451 13 was be VBD cord-010119-t1x9gknd 12451 14 5 5 CD cord-010119-t1x9gknd 12451 15 - - SYM cord-010119-t1x9gknd 12451 16 78 78 CD cord-010119-t1x9gknd 12451 17 days day NNS cord-010119-t1x9gknd 12451 18 ( ( -LRB- cord-010119-t1x9gknd 12451 19 mean mean VB cord-010119-t1x9gknd 12451 20 19 19 CD cord-010119-t1x9gknd 12451 21 days day NNS cord-010119-t1x9gknd 12451 22 , , , cord-010119-t1x9gknd 12451 23 SD SD NNP cord-010119-t1x9gknd 12451 24 20 20 CD cord-010119-t1x9gknd 12451 25 ) ) -RRB- cord-010119-t1x9gknd 12451 26 . . . cord-010119-t1x9gknd 12452 1 In in IN cord-010119-t1x9gknd 12452 2 the the DT cord-010119-t1x9gknd 12452 3 postimplementation postimplementation NN cord-010119-t1x9gknd 12452 4 period period NN cord-010119-t1x9gknd 12452 5 , , , cord-010119-t1x9gknd 12452 6 we -PRON- PRP cord-010119-t1x9gknd 12452 7 cultured culture VBD cord-010119-t1x9gknd 12452 8 22 22 CD cord-010119-t1x9gknd 12452 9 residual residual JJ cord-010119-t1x9gknd 12452 10 products product NNS cord-010119-t1x9gknd 12452 11 for for IN cord-010119-t1x9gknd 12452 12 suspected suspect VBN cord-010119-t1x9gknd 12452 13 STR str NN cord-010119-t1x9gknd 12452 14 . . . cord-010119-t1x9gknd 12453 1 The the DT cord-010119-t1x9gknd 12453 2 TAT tat NN cord-010119-t1x9gknd 12453 3 for for IN cord-010119-t1x9gknd 12453 4 final final JJ cord-010119-t1x9gknd 12453 5 culture culture NN cord-010119-t1x9gknd 12453 6 result result NN cord-010119-t1x9gknd 12453 7 entry entry NN cord-010119-t1x9gknd 12453 8 into into IN cord-010119-t1x9gknd 12453 9 the the DT cord-010119-t1x9gknd 12453 10 patient patient NN cord-010119-t1x9gknd 12453 11 's 's POS cord-010119-t1x9gknd 12453 12 EMR EMR NNP cord-010119-t1x9gknd 12453 13 was be VBD cord-010119-t1x9gknd 12453 14 5 5 CD cord-010119-t1x9gknd 12453 15 - - SYM cord-010119-t1x9gknd 12453 16 12 12 CD cord-010119-t1x9gknd 12453 17 days day NNS cord-010119-t1x9gknd 12453 18 ( ( -LRB- cord-010119-t1x9gknd 12453 19 mean mean VBP cord-010119-t1x9gknd 12453 20 7 7 CD cord-010119-t1x9gknd 12453 21 days day NNS cord-010119-t1x9gknd 12453 22 , , , cord-010119-t1x9gknd 12453 23 SD SD NNP cord-010119-t1x9gknd 12453 24 2 2 CD cord-010119-t1x9gknd 12453 25 ; ; : cord-010119-t1x9gknd 12453 26 p50.0082 p50.0082 NN cord-010119-t1x9gknd 12453 27 ) ) -RRB- cord-010119-t1x9gknd 12453 28 . . . cord-010119-t1x9gknd 12454 1 There there EX cord-010119-t1x9gknd 12454 2 were be VBD cord-010119-t1x9gknd 12454 3 no no DT cord-010119-t1x9gknd 12454 4 positive positive JJ cord-010119-t1x9gknd 12454 5 cultures culture NNS cord-010119-t1x9gknd 12454 6 during during IN cord-010119-t1x9gknd 12454 7 either either DT cord-010119-t1x9gknd 12454 8 study study NN cord-010119-t1x9gknd 12454 9 period period NN cord-010119-t1x9gknd 12454 10 . . . cord-010119-t1x9gknd 12455 1 Conclusion conclusion NN cord-010119-t1x9gknd 12455 2 : : : cord-010119-t1x9gknd 12456 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12456 2 study study NN cord-010119-t1x9gknd 12456 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 12456 4 that that IN cord-010119-t1x9gknd 12456 5 TAT tat NN cord-010119-t1x9gknd 12456 6 for for IN cord-010119-t1x9gknd 12456 7 documentation documentation NN cord-010119-t1x9gknd 12456 8 can can MD cord-010119-t1x9gknd 12456 9 improve improve VB cord-010119-t1x9gknd 12456 10 with with IN cord-010119-t1x9gknd 12456 11 the the DT cord-010119-t1x9gknd 12456 12 use use NN cord-010119-t1x9gknd 12456 13 of of IN cord-010119-t1x9gknd 12456 14 information information NN cord-010119-t1x9gknd 12456 15 technology technology NN cord-010119-t1x9gknd 12456 16 to to TO cord-010119-t1x9gknd 12456 17 notify notify VB cord-010119-t1x9gknd 12456 18 the the DT cord-010119-t1x9gknd 12456 19 Transfusion Transfusion NNP cord-010119-t1x9gknd 12456 20 Medicine Medicine NNP cord-010119-t1x9gknd 12456 21 physician physician NN cord-010119-t1x9gknd 12456 22 when when WRB cord-010119-t1x9gknd 12456 23 results result NNS cord-010119-t1x9gknd 12456 24 are be VBP cord-010119-t1x9gknd 12456 25 available available JJ cord-010119-t1x9gknd 12456 26 for for IN cord-010119-t1x9gknd 12456 27 documentation documentation NN cord-010119-t1x9gknd 12456 28 in in IN cord-010119-t1x9gknd 12456 29 a a DT cord-010119-t1x9gknd 12456 30 patient patient NN cord-010119-t1x9gknd 12456 31 's 's POS cord-010119-t1x9gknd 12456 32 EMR EMR NNP cord-010119-t1x9gknd 12456 33 . . . cord-010119-t1x9gknd 12457 1 Improved Improved NNP cord-010119-t1x9gknd 12457 2 Turnaround Turnaround NNP cord-010119-t1x9gknd 12457 3 Time Time NNP cord-010119-t1x9gknd 12457 4 of of IN cord-010119-t1x9gknd 12457 5 Type type NN cord-010119-t1x9gknd 12457 6 and and CC cord-010119-t1x9gknd 12457 7 Screen screen NN cord-010119-t1x9gknd 12457 8 Samples sample NNS cord-010119-t1x9gknd 12457 9 Michaelene Michaelene NNP cord-010119-t1x9gknd 12457 10 Hultman Hultman NNP cord-010119-t1x9gknd 12458 1 * * NFP cord-010119-t1x9gknd 12458 2 1 1 CD cord-010119-t1x9gknd 12458 3 , , , cord-010119-t1x9gknd 12458 4 Marcus Marcus NNP cord-010119-t1x9gknd 12458 5 Holme Holme NNP cord-010119-t1x9gknd 12458 6 1 1 CD cord-010119-t1x9gknd 12458 7 , , , cord-010119-t1x9gknd 12458 8 Johnathan Johnathan NNP cord-010119-t1x9gknd 12458 9 Bakst Bakst NNP cord-010119-t1x9gknd 12458 10 1 1 CD cord-010119-t1x9gknd 12458 11 , , , cord-010119-t1x9gknd 12458 12 Gunta Gunta NNP cord-010119-t1x9gknd 12458 13 Musa Musa NNP cord-010119-t1x9gknd 12458 14 1 1 CD cord-010119-t1x9gknd 12458 15 and and CC cord-010119-t1x9gknd 12458 16 Angela Angela NNP cord-010119-t1x9gknd 12458 17 Treml Treml NNP cord-010119-t1x9gknd 12458 18 2 2 CD cord-010119-t1x9gknd 12458 19 . . . cord-010119-t1x9gknd 12459 1 1 1 CD cord-010119-t1x9gknd 12459 2 University University NNP cord-010119-t1x9gknd 12459 3 of of IN cord-010119-t1x9gknd 12459 4 Chicago Chicago NNP cord-010119-t1x9gknd 12459 5 Medicine Medicine NNP cord-010119-t1x9gknd 12459 6 , , , cord-010119-t1x9gknd 12459 7 2 2 CD cord-010119-t1x9gknd 12459 8 University University NNP cord-010119-t1x9gknd 12459 9 of of IN cord-010119-t1x9gknd 12459 10 Chicago Chicago NNP cord-010119-t1x9gknd 12459 11 Background Background NNP cord-010119-t1x9gknd 12459 12 / / SYM cord-010119-t1x9gknd 12459 13 Case Case NNP cord-010119-t1x9gknd 12459 14 Studies Studies NNPS cord-010119-t1x9gknd 12459 15 : : : cord-010119-t1x9gknd 12460 1 The the DT cord-010119-t1x9gknd 12460 2 primary primary JJ cord-010119-t1x9gknd 12460 3 test test NN cord-010119-t1x9gknd 12460 4 performed perform VBN cord-010119-t1x9gknd 12460 5 in in IN cord-010119-t1x9gknd 12460 6 the the DT cord-010119-t1x9gknd 12460 7 Blood Blood NNP cord-010119-t1x9gknd 12460 8 Bank Bank NNP cord-010119-t1x9gknd 12460 9 with with IN cord-010119-t1x9gknd 12460 10 regard regard NN cord-010119-t1x9gknd 12460 11 to to IN cord-010119-t1x9gknd 12460 12 pre pre JJ cord-010119-t1x9gknd 12460 13 - - JJ cord-010119-t1x9gknd 12460 14 transfusion transfusion JJ cord-010119-t1x9gknd 12460 15 testing testing NN cord-010119-t1x9gknd 12460 16 is be VBZ cord-010119-t1x9gknd 12460 17 the the DT cord-010119-t1x9gknd 12460 18 Type Type NNP cord-010119-t1x9gknd 12460 19 and and CC cord-010119-t1x9gknd 12460 20 Screen Screen NNP cord-010119-t1x9gknd 12460 21 ( ( -LRB- cord-010119-t1x9gknd 12460 22 TYS TYS NNP cord-010119-t1x9gknd 12460 23 ) ) -RRB- cord-010119-t1x9gknd 12460 24 . . . cord-010119-t1x9gknd 12461 1 The the DT cord-010119-t1x9gknd 12461 2 current current JJ cord-010119-t1x9gknd 12461 3 target target NN cord-010119-t1x9gknd 12461 4 for for IN cord-010119-t1x9gknd 12461 5 this this DT cord-010119-t1x9gknd 12461 6 institution institution NN cord-010119-t1x9gknd 12461 7 's 's POS cord-010119-t1x9gknd 12461 8 blood blood NN cord-010119-t1x9gknd 12461 9 bank bank NN cord-010119-t1x9gknd 12461 10 is be VBZ cord-010119-t1x9gknd 12461 11 an an DT cord-010119-t1x9gknd 12461 12 80 80 CD cord-010119-t1x9gknd 12461 13 minute minute NN cord-010119-t1x9gknd 12461 14 turnaround turnaround NN cord-010119-t1x9gknd 12461 15 time time NN cord-010119-t1x9gknd 12461 16 ( ( -LRB- cord-010119-t1x9gknd 12461 17 TAT tat NN cord-010119-t1x9gknd 12461 18 ) ) -RRB- cord-010119-t1x9gknd 12461 19 . . . cord-010119-t1x9gknd 12462 1 In in IN cord-010119-t1x9gknd 12462 2 April April NNP cord-010119-t1x9gknd 12462 3 of of IN cord-010119-t1x9gknd 12462 4 2016 2016 CD cord-010119-t1x9gknd 12462 5 , , , cord-010119-t1x9gknd 12462 6 the the DT cord-010119-t1x9gknd 12462 7 blood blood NN cord-010119-t1x9gknd 12462 8 bank bank NN cord-010119-t1x9gknd 12462 9 was be VBD cord-010119-t1x9gknd 12462 10 forced force VBN cord-010119-t1x9gknd 12462 11 to to TO cord-010119-t1x9gknd 12462 12 move move VB cord-010119-t1x9gknd 12462 13 to to IN cord-010119-t1x9gknd 12462 14 a a DT cord-010119-t1x9gknd 12462 15 temporary temporary JJ cord-010119-t1x9gknd 12462 16 location location NN cord-010119-t1x9gknd 12462 17 due due IN cord-010119-t1x9gknd 12462 18 to to IN cord-010119-t1x9gknd 12462 19 building building NN cord-010119-t1x9gknd 12462 20 construction construction NN cord-010119-t1x9gknd 12462 21 , , , cord-010119-t1x9gknd 12462 22 which which WDT cord-010119-t1x9gknd 12462 23 necessitated necessitate VBD cord-010119-t1x9gknd 12462 24 a a DT cord-010119-t1x9gknd 12462 25 switch switch NN cord-010119-t1x9gknd 12462 26 from from IN cord-010119-t1x9gknd 12462 27 automated automate VBN cord-010119-t1x9gknd 12462 28 solid solid JJ cord-010119-t1x9gknd 12462 29 phase phase NN cord-010119-t1x9gknd 12462 30 methodology methodology NN cord-010119-t1x9gknd 12462 31 to to IN cord-010119-t1x9gknd 12462 32 manual manual JJ cord-010119-t1x9gknd 12462 33 gel gel NN cord-010119-t1x9gknd 12462 34 method method NN cord-010119-t1x9gknd 12462 35 . . . cord-010119-t1x9gknd 12463 1 The the DT cord-010119-t1x9gknd 12463 2 average average JJ cord-010119-t1x9gknd 12463 3 number number NN cord-010119-t1x9gknd 12463 4 of of IN cord-010119-t1x9gknd 12463 5 outliers outlier NNS cord-010119-t1x9gknd 12463 6 increased increase VBD cord-010119-t1x9gknd 12463 7 104 104 CD cord-010119-t1x9gknd 12463 8 % % NN cord-010119-t1x9gknd 12463 9 . . . cord-010119-t1x9gknd 12464 1 TAT tat NN cord-010119-t1x9gknd 12464 2 analysis analysis NN cord-010119-t1x9gknd 12464 3 of of IN cord-010119-t1x9gknd 12464 4 a a DT cord-010119-t1x9gknd 12464 5 representative representative JJ cord-010119-t1x9gknd 12464 6 one one CD cord-010119-t1x9gknd 12464 7 week week NN cord-010119-t1x9gknd 12464 8 sampling sampling NN cord-010119-t1x9gknd 12464 9 per per IN cord-010119-t1x9gknd 12464 10 month month NN cord-010119-t1x9gknd 12464 11 showed show VBD cord-010119-t1x9gknd 12464 12 an an DT cord-010119-t1x9gknd 12464 13 increase increase NN cord-010119-t1x9gknd 12464 14 in in IN cord-010119-t1x9gknd 12464 15 outliers outlier NNS cord-010119-t1x9gknd 12464 16 from from IN cord-010119-t1x9gknd 12464 17 28 28 CD cord-010119-t1x9gknd 12464 18 per per IN cord-010119-t1x9gknd 12464 19 month month NN cord-010119-t1x9gknd 12464 20 to to IN cord-010119-t1x9gknd 12464 21 57 57 CD cord-010119-t1x9gknd 12464 22 per per IN cord-010119-t1x9gknd 12464 23 month month NN cord-010119-t1x9gknd 12464 24 . . . cord-010119-t1x9gknd 12465 1 Average average JJ cord-010119-t1x9gknd 12465 2 monthly monthly JJ cord-010119-t1x9gknd 12465 3 TYS TYS NNP cord-010119-t1x9gknd 12465 4 samples sample NNS cord-010119-t1x9gknd 12465 5 performed perform VBN cord-010119-t1x9gknd 12465 6 is be VBZ cord-010119-t1x9gknd 12465 7 2758 2758 CD cord-010119-t1x9gknd 12465 8 . . . cord-010119-t1x9gknd 12466 1 These these DT cord-010119-t1x9gknd 12466 2 numbers number NNS cord-010119-t1x9gknd 12466 3 did do VBD cord-010119-t1x9gknd 12466 4 not not RB cord-010119-t1x9gknd 12466 5 improve improve VB cord-010119-t1x9gknd 12466 6 even even RB cord-010119-t1x9gknd 12466 7 upon upon IN cord-010119-t1x9gknd 12466 8 returning return VBG cord-010119-t1x9gknd 12466 9 to to IN cord-010119-t1x9gknd 12466 10 the the DT cord-010119-t1x9gknd 12466 11 original original JJ cord-010119-t1x9gknd 12466 12 facilities facility NNS cord-010119-t1x9gknd 12466 13 . . . cord-010119-t1x9gknd 12467 1 Study Study NNP cord-010119-t1x9gknd 12467 2 Design Design NNP cord-010119-t1x9gknd 12467 3 / / SYM cord-010119-t1x9gknd 12467 4 Method method NN cord-010119-t1x9gknd 12467 5 : : : cord-010119-t1x9gknd 12468 1 Two two CD cord-010119-t1x9gknd 12468 2 Ortho Ortho NNP cord-010119-t1x9gknd 12468 3 Clinical Clinical NNP cord-010119-t1x9gknd 12468 4 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 12468 5 VisionV visionv NN cord-010119-t1x9gknd 12468 6 R r NN cord-010119-t1x9gknd 12468 7 Analyzers Analyzers NNPS cord-010119-t1x9gknd 12468 8 ( ( -LRB- cord-010119-t1x9gknd 12468 9 Raritan Raritan NNP cord-010119-t1x9gknd 12468 10 , , , cord-010119-t1x9gknd 12468 11 N.J. New Jersey NNP cord-010119-t1x9gknd 12468 12 ) ) -RRB- cord-010119-t1x9gknd 12468 13 were be VBD cord-010119-t1x9gknd 12468 14 purchased purchase VBN cord-010119-t1x9gknd 12468 15 for for IN cord-010119-t1x9gknd 12468 16 the the DT cord-010119-t1x9gknd 12468 17 blood blood NN cord-010119-t1x9gknd 12468 18 bank bank NN cord-010119-t1x9gknd 12468 19 . . . cord-010119-t1x9gknd 12469 1 The the DT cord-010119-t1x9gknd 12469 2 instruments instrument NNS cord-010119-t1x9gknd 12469 3 were be VBD cord-010119-t1x9gknd 12469 4 set set VBN cord-010119-t1x9gknd 12469 5 up up RP cord-010119-t1x9gknd 12469 6 with with IN cord-010119-t1x9gknd 12469 7 a a DT cord-010119-t1x9gknd 12469 8 bi bi JJ cord-010119-t1x9gknd 12469 9 - - JJ cord-010119-t1x9gknd 12469 10 directional directional JJ cord-010119-t1x9gknd 12469 11 interface interface NN cord-010119-t1x9gknd 12469 12 allowing allow VBG cord-010119-t1x9gknd 12469 13 for for IN cord-010119-t1x9gknd 12469 14 samples sample NNS cord-010119-t1x9gknd 12469 15 to to TO cord-010119-t1x9gknd 12469 16 be be VB cord-010119-t1x9gknd 12469 17 continuously continuously RB cord-010119-t1x9gknd 12469 18 loaded load VBN cord-010119-t1x9gknd 12469 19 without without IN cord-010119-t1x9gknd 12469 20 manually manually RB cord-010119-t1x9gknd 12469 21 ordering order VBG cord-010119-t1x9gknd 12469 22 the the DT cord-010119-t1x9gknd 12469 23 tests test NNS cord-010119-t1x9gknd 12469 24 . . . cord-010119-t1x9gknd 12470 1 Batch batch JJ cord-010119-t1x9gknd 12470 2 testing testing NN cord-010119-t1x9gknd 12470 3 was be VBD cord-010119-t1x9gknd 12470 4 eliminated eliminate VBN cord-010119-t1x9gknd 12470 5 allowing allow VBG cord-010119-t1x9gknd 12470 6 samples sample NNS cord-010119-t1x9gknd 12470 7 to to TO cord-010119-t1x9gknd 12470 8 be be VB cord-010119-t1x9gknd 12470 9 run run VBN cord-010119-t1x9gknd 12470 10 as as IN cord-010119-t1x9gknd 12470 11 received receive VBN cord-010119-t1x9gknd 12470 12 . . . cord-010119-t1x9gknd 12471 1 The the DT cord-010119-t1x9gknd 12471 2 results result NNS cord-010119-t1x9gknd 12471 3 were be VBD cord-010119-t1x9gknd 12471 4 auto auto NN cord-010119-t1x9gknd 12471 5 interpreted interpret VBN cord-010119-t1x9gknd 12471 6 , , , cord-010119-t1x9gknd 12471 7 and and CC cord-010119-t1x9gknd 12471 8 transmitted transmit VBN cord-010119-t1x9gknd 12471 9 to to IN cord-010119-t1x9gknd 12471 10 the the DT cord-010119-t1x9gknd 12471 11 laboratory laboratory NN cord-010119-t1x9gknd 12471 12 information information NN cord-010119-t1x9gknd 12471 13 system system NN cord-010119-t1x9gknd 12471 14 ( ( -LRB- cord-010119-t1x9gknd 12471 15 LIS LIS NNP cord-010119-t1x9gknd 12471 16 ) ) -RRB- cord-010119-t1x9gknd 12471 17 based base VBN cord-010119-t1x9gknd 12471 18 on on IN cord-010119-t1x9gknd 12471 19 predetermined predetermine VBN cord-010119-t1x9gknd 12471 20 rules rule NNS cord-010119-t1x9gknd 12471 21 . . . cord-010119-t1x9gknd 12472 1 Only only RB cord-010119-t1x9gknd 12472 2 results result NNS cord-010119-t1x9gknd 12472 3 in in IN cord-010119-t1x9gknd 12472 4 need need NN cord-010119-t1x9gknd 12472 5 of of IN cord-010119-t1x9gknd 12472 6 manual manual JJ cord-010119-t1x9gknd 12472 7 review review NN cord-010119-t1x9gknd 12472 8 or or CC cord-010119-t1x9gknd 12472 9 interpretation interpretation NN cord-010119-t1x9gknd 12472 10 were be VBD cord-010119-t1x9gknd 12472 11 held hold VBN cord-010119-t1x9gknd 12472 12 back back RB cord-010119-t1x9gknd 12472 13 . . . cord-010119-t1x9gknd 12473 1 Final final JJ cord-010119-t1x9gknd 12473 2 verification verification NN cord-010119-t1x9gknd 12473 3 of of IN cord-010119-t1x9gknd 12473 4 results result NNS cord-010119-t1x9gknd 12473 5 was be VBD cord-010119-t1x9gknd 12473 6 performed perform VBN cord-010119-t1x9gknd 12473 7 by by IN cord-010119-t1x9gknd 12473 8 the the DT cord-010119-t1x9gknd 12473 9 technologist technologist NN cord-010119-t1x9gknd 12473 10 within within IN cord-010119-t1x9gknd 12473 11 the the DT cord-010119-t1x9gknd 12473 12 LIS LIS NNP cord-010119-t1x9gknd 12473 13 . . . cord-010119-t1x9gknd 12474 1 Reagents reagent NNS cord-010119-t1x9gknd 12474 2 and and CC cord-010119-t1x9gknd 12474 3 other other JJ cord-010119-t1x9gknd 12474 4 needed need VBN cord-010119-t1x9gknd 12474 5 consumables consumable NNS cord-010119-t1x9gknd 12474 6 could could MD cord-010119-t1x9gknd 12474 7 be be VB cord-010119-t1x9gknd 12474 8 preloaded preloade VBN cord-010119-t1x9gknd 12474 9 on on IN cord-010119-t1x9gknd 12474 10 the the DT cord-010119-t1x9gknd 12474 11 instruments instrument NNS cord-010119-t1x9gknd 12474 12 eliminating eliminate VBG cord-010119-t1x9gknd 12474 13 the the DT cord-010119-t1x9gknd 12474 14 need need NN cord-010119-t1x9gknd 12474 15 to to TO cord-010119-t1x9gknd 12474 16 repeatedly repeatedly RB cord-010119-t1x9gknd 12474 17 load load VB cord-010119-t1x9gknd 12474 18 consumables consumable NNS cord-010119-t1x9gknd 12474 19 with with IN cord-010119-t1x9gknd 12474 20 each each DT cord-010119-t1x9gknd 12474 21 sample sample NN cord-010119-t1x9gknd 12474 22 run run NN cord-010119-t1x9gknd 12474 23 . . . cord-010119-t1x9gknd 12475 1 Key key JJ cord-010119-t1x9gknd 12475 2 quality quality NN cord-010119-t1x9gknd 12475 3 indicators indicator NNS cord-010119-t1x9gknd 12475 4 including include VBG cord-010119-t1x9gknd 12475 5 TAT tat NN cord-010119-t1x9gknd 12475 6 continued continue VBD cord-010119-t1x9gknd 12475 7 to to TO cord-010119-t1x9gknd 12475 8 be be VB cord-010119-t1x9gknd 12475 9 monitored monitor VBN cord-010119-t1x9gknd 12475 10 throughout throughout IN cord-010119-t1x9gknd 12475 11 implementation implementation NN cord-010119-t1x9gknd 12475 12 . . . cord-010119-t1x9gknd 12476 1 Data datum NNS cord-010119-t1x9gknd 12476 2 was be VBD cord-010119-t1x9gknd 12476 3 monitored monitor VBN cord-010119-t1x9gknd 12476 4 for for IN cord-010119-t1x9gknd 12476 5 significant significant JJ cord-010119-t1x9gknd 12476 6 changes change NNS cord-010119-t1x9gknd 12476 7 and and CC cord-010119-t1x9gknd 12476 8 improvements improvement NNS cord-010119-t1x9gknd 12476 9 in in IN cord-010119-t1x9gknd 12476 10 patient patient JJ cord-010119-t1x9gknd 12476 11 care care NN cord-010119-t1x9gknd 12476 12 . . . cord-010119-t1x9gknd 12477 1 The the DT cord-010119-t1x9gknd 12477 2 go go VB cord-010119-t1x9gknd 12477 3 - - HYPH cord-010119-t1x9gknd 12477 4 live live JJ cord-010119-t1x9gknd 12477 5 date date NN cord-010119-t1x9gknd 12477 6 was be VBD cord-010119-t1x9gknd 12477 7 12/20/ 12/20/ CD cord-010119-t1x9gknd 12477 8 2016 2016 CD cord-010119-t1x9gknd 12477 9 . . . cord-010119-t1x9gknd 12478 1 Results/ Results/ . cord-010119-t1x9gknd 12479 1 Finding finding NN cord-010119-t1x9gknd 12479 2 : : : cord-010119-t1x9gknd 12480 1 The the DT cord-010119-t1x9gknd 12480 2 average average JJ cord-010119-t1x9gknd 12480 3 number number NN cord-010119-t1x9gknd 12480 4 of of IN cord-010119-t1x9gknd 12480 5 outliers outlier NNS cord-010119-t1x9gknd 12480 6 decreased decrease VBD cord-010119-t1x9gknd 12480 7 61 61 CD cord-010119-t1x9gknd 12480 8 % % NN cord-010119-t1x9gknd 12480 9 from from IN cord-010119-t1x9gknd 12480 10 57 57 CD cord-010119-t1x9gknd 12480 11 per per IN cord-010119-t1x9gknd 12480 12 month month NN cord-010119-t1x9gknd 12480 13 to to IN cord-010119-t1x9gknd 12480 14 22 22 CD cord-010119-t1x9gknd 12480 15 . . . cord-010119-t1x9gknd 12481 1 Further further JJ cord-010119-t1x9gknd 12481 2 benefits benefit NNS cord-010119-t1x9gknd 12481 3 include include VBP cord-010119-t1x9gknd 12481 4 a a DT cord-010119-t1x9gknd 12481 5 reduction reduction NN cord-010119-t1x9gknd 12481 6 in in IN cord-010119-t1x9gknd 12481 7 the the DT cord-010119-t1x9gknd 12481 8 number number NN cord-010119-t1x9gknd 12481 9 of of IN cord-010119-t1x9gknd 12481 10 technologists technologist NNS cord-010119-t1x9gknd 12481 11 needed need VBN cord-010119-t1x9gknd 12481 12 to to TO cord-010119-t1x9gknd 12481 13 perform perform VB cord-010119-t1x9gknd 12481 14 TYS TYS NNP cord-010119-t1x9gknd 12481 15 testing testing NN cord-010119-t1x9gknd 12481 16 . . . cord-010119-t1x9gknd 12482 1 Additionally additionally RB cord-010119-t1x9gknd 12482 2 , , , cord-010119-t1x9gknd 12482 3 reduced reduce VBN cord-010119-t1x9gknd 12482 4 waste waste NN cord-010119-t1x9gknd 12482 5 due due IN cord-010119-t1x9gknd 12482 6 to to IN cord-010119-t1x9gknd 12482 7 better well JJR cord-010119-t1x9gknd 12482 8 utilization utilization NN cord-010119-t1x9gknd 12482 9 of of IN cord-010119-t1x9gknd 12482 10 supplies supply NNS cord-010119-t1x9gknd 12482 11 by by IN cord-010119-t1x9gknd 12482 12 the the DT cord-010119-t1x9gknd 12482 13 instruments instrument NNS cord-010119-t1x9gknd 12482 14 along along IN cord-010119-t1x9gknd 12482 15 with with IN cord-010119-t1x9gknd 12482 16 less less JJR cord-010119-t1x9gknd 12482 17 repeat repeat NN cord-010119-t1x9gknd 12482 18 testing testing NN cord-010119-t1x9gknd 12482 19 has have VBZ cord-010119-t1x9gknd 12482 20 resulted result VBN cord-010119-t1x9gknd 12482 21 in in IN cord-010119-t1x9gknd 12482 22 projected project VBN cord-010119-t1x9gknd 12482 23 cost cost NN cord-010119-t1x9gknd 12482 24 savings saving NNS cord-010119-t1x9gknd 12482 25 of of IN cord-010119-t1x9gknd 12482 26 $ $ $ cord-010119-t1x9gknd 12482 27 134,000 134,000 CD cord-010119-t1x9gknd 12482 28 for for IN cord-010119-t1x9gknd 12482 29 fiscal fiscal JJ cord-010119-t1x9gknd 12482 30 year year NN cord-010119-t1x9gknd 12482 31 2017 2017 CD cord-010119-t1x9gknd 12482 32 . . . cord-010119-t1x9gknd 12483 1 Conclusion conclusion NN cord-010119-t1x9gknd 12483 2 : : : cord-010119-t1x9gknd 12484 1 The the DT cord-010119-t1x9gknd 12484 2 use use NN cord-010119-t1x9gknd 12484 3 of of IN cord-010119-t1x9gknd 12484 4 gel gel NN cord-010119-t1x9gknd 12484 5 technology technology NN cord-010119-t1x9gknd 12484 6 , , , cord-010119-t1x9gknd 12484 7 in in IN cord-010119-t1x9gknd 12484 8 combination combination NN cord-010119-t1x9gknd 12484 9 with with IN cord-010119-t1x9gknd 12484 10 a a DT cord-010119-t1x9gknd 12484 11 two two CD cord-010119-t1x9gknd 12484 12 way way NN cord-010119-t1x9gknd 12484 13 interface interface NN cord-010119-t1x9gknd 12484 14 and and CC cord-010119-t1x9gknd 12484 15 a a DT cord-010119-t1x9gknd 12484 16 continuous continuous JJ cord-010119-t1x9gknd 12484 17 load load NN cord-010119-t1x9gknd 12484 18 instrument instrument NN cord-010119-t1x9gknd 12484 19 can can MD cord-010119-t1x9gknd 12484 20 result result VB cord-010119-t1x9gknd 12484 21 in in IN cord-010119-t1x9gknd 12484 22 a a DT cord-010119-t1x9gknd 12484 23 significant significant JJ cord-010119-t1x9gknd 12484 24 decrease decrease NN cord-010119-t1x9gknd 12484 25 in in IN cord-010119-t1x9gknd 12484 26 TAT TAT NNP cord-010119-t1x9gknd 12484 27 over over IN cord-010119-t1x9gknd 12484 28 manual manual JJ cord-010119-t1x9gknd 12484 29 gel gel NN cord-010119-t1x9gknd 12484 30 method method NN cord-010119-t1x9gknd 12484 31 . . . cord-010119-t1x9gknd 12485 1 Improvements improvement NNS cord-010119-t1x9gknd 12485 2 in in IN cord-010119-t1x9gknd 12485 3 the the DT cord-010119-t1x9gknd 12485 4 Timely Timely NNP cord-010119-t1x9gknd 12485 5 Reporting Reporting NNP cord-010119-t1x9gknd 12485 6 of of IN cord-010119-t1x9gknd 12485 7 Final Final NNP cord-010119-t1x9gknd 12485 8 Product product NN cord-010119-t1x9gknd 12485 9 Culture culture NN cord-010119-t1x9gknd 12485 10 Results result NNS cord-010119-t1x9gknd 12485 11 in in IN cord-010119-t1x9gknd 12485 12 the the DT cord-010119-t1x9gknd 12485 13 Patient Patient NNP cord-010119-t1x9gknd 12485 14 's 's POS cord-010119-t1x9gknd 12485 15 EMR EMR NNP cord-010119-t1x9gknd 12485 16 . . . cord-010119-t1x9gknd 12486 1 Barbara Barbara NNP cord-010119-t1x9gknd 12486 2 A. A. NNP cord-010119-t1x9gknd 12486 3 Hewitt Hewitt NNP cord-010119-t1x9gknd 12487 1 * * NFP cord-010119-t1x9gknd 12487 2 . . . cord-010119-t1x9gknd 12488 1 Dartmouth Dartmouth NNP cord-010119-t1x9gknd 12488 2 Hitchcock Hitchcock NNP cord-010119-t1x9gknd 12488 3 Medical Medical NNP cord-010119-t1x9gknd 12488 4 Center Center NNP cord-010119-t1x9gknd 12488 5 Background Background NNP cord-010119-t1x9gknd 12488 6 / / SYM cord-010119-t1x9gknd 12488 7 Case Case NNP cord-010119-t1x9gknd 12488 8 Studies Studies NNPS cord-010119-t1x9gknd 12488 9 : : : cord-010119-t1x9gknd 12488 10 In in IN cord-010119-t1x9gknd 12488 11 certain certain JJ cord-010119-t1x9gknd 12488 12 transfusion transfusion NN cord-010119-t1x9gknd 12488 13 reactions reaction NNS cord-010119-t1x9gknd 12488 14 it -PRON- PRP cord-010119-t1x9gknd 12488 15 is be VBZ cord-010119-t1x9gknd 12488 16 required require VBN cord-010119-t1x9gknd 12488 17 that that IN cord-010119-t1x9gknd 12488 18 a a DT cord-010119-t1x9gknd 12488 19 culture culture NN cord-010119-t1x9gknd 12488 20 of of IN cord-010119-t1x9gknd 12488 21 the the DT cord-010119-t1x9gknd 12488 22 returned return VBN cord-010119-t1x9gknd 12488 23 blood blood NN cord-010119-t1x9gknd 12488 24 product product NN cord-010119-t1x9gknd 12488 25 be be VB cord-010119-t1x9gknd 12488 26 performed perform VBN cord-010119-t1x9gknd 12488 27 . . . cord-010119-t1x9gknd 12489 1 These these DT cord-010119-t1x9gknd 12489 2 cultures culture NNS cord-010119-t1x9gknd 12489 3 are be VBP cord-010119-t1x9gknd 12489 4 reported report VBN cord-010119-t1x9gknd 12489 5 in in IN cord-010119-t1x9gknd 12489 6 our -PRON- PRP$ cord-010119-t1x9gknd 12489 7 Cerner Cerner NNP cord-010119-t1x9gknd 12489 8 operating operate VBG cord-010119-t1x9gknd 12489 9 system system NN cord-010119-t1x9gknd 12489 10 but but CC cord-010119-t1x9gknd 12489 11 those those DT cord-010119-t1x9gknd 12489 12 results result NNS cord-010119-t1x9gknd 12489 13 do do VBP cord-010119-t1x9gknd 12489 14 not not RB cord-010119-t1x9gknd 12489 15 cross cross VB cord-010119-t1x9gknd 12489 16 over over RP cord-010119-t1x9gknd 12489 17 to to IN cord-010119-t1x9gknd 12489 18 the the DT cord-010119-t1x9gknd 12489 19 patient patient NN cord-010119-t1x9gknd 12489 20 's 's POS cord-010119-t1x9gknd 12489 21 EMR EMR NNP cord-010119-t1x9gknd 12489 22 . . . cord-010119-t1x9gknd 12490 1 The the DT cord-010119-t1x9gknd 12490 2 finalized finalize VBN cord-010119-t1x9gknd 12490 3 product product NN cord-010119-t1x9gknd 12490 4 culture culture NN cord-010119-t1x9gknd 12490 5 results result NNS cord-010119-t1x9gknd 12490 6 are be VBP cord-010119-t1x9gknd 12490 7 entered enter VBN cord-010119-t1x9gknd 12490 8 into into IN cord-010119-t1x9gknd 12490 9 the the DT cord-010119-t1x9gknd 12490 10 patient patient NN cord-010119-t1x9gknd 12490 11 's 's POS cord-010119-t1x9gknd 12490 12 EMR EMR NNP cord-010119-t1x9gknd 12490 13 as as IN cord-010119-t1x9gknd 12490 14 an an DT cord-010119-t1x9gknd 12490 15 addendum addendum NN cord-010119-t1x9gknd 12490 16 to to IN cord-010119-t1x9gknd 12490 17 the the DT cord-010119-t1x9gknd 12490 18 transfusion transfusion NN cord-010119-t1x9gknd 12490 19 reaction reaction NN cord-010119-t1x9gknd 12490 20 clinical clinical JJ cord-010119-t1x9gknd 12490 21 note note NN cord-010119-t1x9gknd 12490 22 . . . cord-010119-t1x9gknd 12491 1 A a DT cord-010119-t1x9gknd 12491 2 review review NN cord-010119-t1x9gknd 12491 3 of of IN cord-010119-t1x9gknd 12491 4 the the DT cord-010119-t1x9gknd 12491 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 12491 6 Reaction Reaction NNP cord-010119-t1x9gknd 12491 7 database database NN cord-010119-t1x9gknd 12491 8 revealed reveal VBD cord-010119-t1x9gknd 12491 9 that that IN cord-010119-t1x9gknd 12491 10 there there EX cord-010119-t1x9gknd 12491 11 were be VBD cord-010119-t1x9gknd 12491 12 occasions occasion NNS cord-010119-t1x9gknd 12491 13 when when WRB cord-010119-t1x9gknd 12491 14 the the DT cord-010119-t1x9gknd 12491 15 final final JJ cord-010119-t1x9gknd 12491 16 product product NN cord-010119-t1x9gknd 12491 17 culture culture NN cord-010119-t1x9gknd 12491 18 results result NNS cord-010119-t1x9gknd 12491 19 were be VBD cord-010119-t1x9gknd 12491 20 not not RB cord-010119-t1x9gknd 12491 21 entered enter VBN cord-010119-t1x9gknd 12491 22 into into IN cord-010119-t1x9gknd 12491 23 the the DT cord-010119-t1x9gknd 12491 24 patient patient NN cord-010119-t1x9gknd 12491 25 's 's POS cord-010119-t1x9gknd 12491 26 EMR EMR NNP cord-010119-t1x9gknd 12491 27 in in IN cord-010119-t1x9gknd 12491 28 a a DT cord-010119-t1x9gknd 12491 29 timely timely JJ cord-010119-t1x9gknd 12491 30 manner manner NN cord-010119-t1x9gknd 12491 31 . . . cord-010119-t1x9gknd 12492 1 It -PRON- PRP cord-010119-t1x9gknd 12492 2 is be VBZ cord-010119-t1x9gknd 12492 3 important important JJ cord-010119-t1x9gknd 12492 4 to to IN cord-010119-t1x9gknd 12492 5 the the DT cord-010119-t1x9gknd 12492 6 patient patient NN cord-010119-t1x9gknd 12492 7 's 's POS cord-010119-t1x9gknd 12492 8 care care NN cord-010119-t1x9gknd 12492 9 for for IN cord-010119-t1x9gknd 12492 10 the the DT cord-010119-t1x9gknd 12492 11 Transfusion Transfusion NNP cord-010119-t1x9gknd 12492 12 Medicine Medicine NNP cord-010119-t1x9gknd 12492 13 Service Service NNP cord-010119-t1x9gknd 12492 14 and and CC cord-010119-t1x9gknd 12492 15 the the DT cord-010119-t1x9gknd 12492 16 patient patient NN cord-010119-t1x9gknd 12492 17 's 's POS cord-010119-t1x9gknd 12492 18 primary primary JJ cord-010119-t1x9gknd 12492 19 provider provider NN cord-010119-t1x9gknd 12492 20 to to TO cord-010119-t1x9gknd 12492 21 know know VB cord-010119-t1x9gknd 12492 22 if if IN cord-010119-t1x9gknd 12492 23 a a DT cord-010119-t1x9gknd 12492 24 transfusion transfusion NN cord-010119-t1x9gknd 12492 25 reaction reaction NN cord-010119-t1x9gknd 12492 26 is be VBZ cord-010119-t1x9gknd 12492 27 related relate VBN cord-010119-t1x9gknd 12492 28 to to IN cord-010119-t1x9gknd 12492 29 a a DT cord-010119-t1x9gknd 12492 30 contaminated contaminate VBN cord-010119-t1x9gknd 12492 31 product product NN cord-010119-t1x9gknd 12492 32 or or CC cord-010119-t1x9gknd 12492 33 the the DT cord-010119-t1x9gknd 12492 34 patient patient NN cord-010119-t1x9gknd 12492 35 's 's POS cord-010119-t1x9gknd 12492 36 general general JJ cord-010119-t1x9gknd 12492 37 overall overall JJ cord-010119-t1x9gknd 12492 38 health health NN cord-010119-t1x9gknd 12492 39 . . . cord-010119-t1x9gknd 12493 1 This this DT cord-010119-t1x9gknd 12493 2 information information NN cord-010119-t1x9gknd 12493 3 is be VBZ cord-010119-t1x9gknd 12493 4 also also RB cord-010119-t1x9gknd 12493 5 crucial crucial JJ cord-010119-t1x9gknd 12493 6 to to IN cord-010119-t1x9gknd 12493 7 the the DT cord-010119-t1x9gknd 12493 8 supplier supplier NN cord-010119-t1x9gknd 12493 9 of of IN cord-010119-t1x9gknd 12493 10 the the DT cord-010119-t1x9gknd 12493 11 product product NN cord-010119-t1x9gknd 12493 12 to to TO cord-010119-t1x9gknd 12493 13 determine determine VB cord-010119-t1x9gknd 12493 14 if if IN cord-010119-t1x9gknd 12493 15 others other NNS cord-010119-t1x9gknd 12493 16 have have VBP cord-010119-t1x9gknd 12493 17 received receive VBN cord-010119-t1x9gknd 12493 18 components component NNS cord-010119-t1x9gknd 12493 19 of of IN cord-010119-t1x9gknd 12493 20 the the DT cord-010119-t1x9gknd 12493 21 affected affected JJ cord-010119-t1x9gknd 12493 22 unit unit NN cord-010119-t1x9gknd 12493 23 and and CC cord-010119-t1x9gknd 12493 24 to to TO cord-010119-t1x9gknd 12493 25 possibly possibly RB cord-010119-t1x9gknd 12493 26 determine determine VB cord-010119-t1x9gknd 12493 27 if if IN cord-010119-t1x9gknd 12493 28 there there EX cord-010119-t1x9gknd 12493 29 are be VBP cord-010119-t1x9gknd 12493 30 any any DT cord-010119-t1x9gknd 12493 31 quality quality NN cord-010119-t1x9gknd 12493 32 control control NN cord-010119-t1x9gknd 12493 33 issues issue NNS cord-010119-t1x9gknd 12493 34 at at IN cord-010119-t1x9gknd 12493 35 the the DT cord-010119-t1x9gknd 12493 36 donor donor NN cord-010119-t1x9gknd 12493 37 facility facility NN cord-010119-t1x9gknd 12493 38 . . . cord-010119-t1x9gknd 12494 1 Study Study NNP cord-010119-t1x9gknd 12494 2 Design Design NNP cord-010119-t1x9gknd 12494 3 / / SYM cord-010119-t1x9gknd 12494 4 Methods method NNS cord-010119-t1x9gknd 12494 5 : : : cord-010119-t1x9gknd 12495 1 A a DT cord-010119-t1x9gknd 12495 2 review review NN cord-010119-t1x9gknd 12495 3 of of IN cord-010119-t1x9gknd 12495 4 a a DT cord-010119-t1x9gknd 12495 5 specific specific JJ cord-010119-t1x9gknd 12495 6 7 7 CD cord-010119-t1x9gknd 12495 7 month month NN cord-010119-t1x9gknd 12495 8 period period NN cord-010119-t1x9gknd 12495 9 revealed reveal VBD cord-010119-t1x9gknd 12495 10 that that IN cord-010119-t1x9gknd 12495 11 the the DT cord-010119-t1x9gknd 12495 12 timeframe timeframe NN cord-010119-t1x9gknd 12495 13 in in IN cord-010119-t1x9gknd 12495 14 which which WDT cord-010119-t1x9gknd 12495 15 the the DT cord-010119-t1x9gknd 12495 16 finalized finalize VBN cord-010119-t1x9gknd 12495 17 product product NN cord-010119-t1x9gknd 12495 18 culture culture NN cord-010119-t1x9gknd 12495 19 results result NNS cord-010119-t1x9gknd 12495 20 were be VBD cord-010119-t1x9gknd 12495 21 entered enter VBN cord-010119-t1x9gknd 12495 22 into into IN cord-010119-t1x9gknd 12495 23 the the DT cord-010119-t1x9gknd 12495 24 patient patient NN cord-010119-t1x9gknd 12495 25 's 's POS cord-010119-t1x9gknd 12495 26 EMR EMR NNP cord-010119-t1x9gknd 12495 27 ranged range VBD cord-010119-t1x9gknd 12495 28 from from IN cord-010119-t1x9gknd 12495 29 0 0 CD cord-010119-t1x9gknd 12495 30 - - SYM cord-010119-t1x9gknd 12495 31 65 65 CD cord-010119-t1x9gknd 12495 32 days day NNS cord-010119-t1x9gknd 12495 33 with with IN cord-010119-t1x9gknd 12495 34 a a DT cord-010119-t1x9gknd 12495 35 mean mean NN cord-010119-t1x9gknd 12495 36 of of IN cord-010119-t1x9gknd 12495 37 13.64 13.64 CD cord-010119-t1x9gknd 12495 38 days day NNS cord-010119-t1x9gknd 12495 39 . . . cord-010119-t1x9gknd 12496 1 It -PRON- PRP cord-010119-t1x9gknd 12496 2 was be VBD cord-010119-t1x9gknd 12496 3 determined determine VBN cord-010119-t1x9gknd 12496 4 that that IN cord-010119-t1x9gknd 12496 5 this this DT cord-010119-t1x9gknd 12496 6 was be VBD cord-010119-t1x9gknd 12496 7 not not RB cord-010119-t1x9gknd 12496 8 in in IN cord-010119-t1x9gknd 12496 9 the the DT cord-010119-t1x9gknd 12496 10 interest interest NN cord-010119-t1x9gknd 12496 11 of of IN cord-010119-t1x9gknd 12496 12 improving improve VBG cord-010119-t1x9gknd 12496 13 patient patient JJ cord-010119-t1x9gknd 12496 14 care care NN cord-010119-t1x9gknd 12496 15 . . . cord-010119-t1x9gknd 12497 1 In in IN cord-010119-t1x9gknd 12497 2 collaboration collaboration NN cord-010119-t1x9gknd 12497 3 with with IN cord-010119-t1x9gknd 12497 4 Laboratory Laboratory NNP cord-010119-t1x9gknd 12497 5 Information Information NNP cord-010119-t1x9gknd 12497 6 Services Services NNP cord-010119-t1x9gknd 12497 7 a a DT cord-010119-t1x9gknd 12497 8 report report NN cord-010119-t1x9gknd 12497 9 was be VBD cord-010119-t1x9gknd 12497 10 created create VBN cord-010119-t1x9gknd 12497 11 in in IN cord-010119-t1x9gknd 12497 12 which which WDT cord-010119-t1x9gknd 12497 13 once once IN cord-010119-t1x9gknd 12497 14 product product NN cord-010119-t1x9gknd 12497 15 culture culture NN cord-010119-t1x9gknd 12497 16 results result NNS cord-010119-t1x9gknd 12497 17 were be VBD cord-010119-t1x9gknd 12497 18 finalized finalize VBN cord-010119-t1x9gknd 12497 19 an an DT cord-010119-t1x9gknd 12497 20 email email NN cord-010119-t1x9gknd 12497 21 would would MD cord-010119-t1x9gknd 12497 22 be be VB cord-010119-t1x9gknd 12497 23 generated generate VBN cord-010119-t1x9gknd 12497 24 notifying notify VBG cord-010119-t1x9gknd 12497 25 the the DT cord-010119-t1x9gknd 12497 26 Medical Medical NNP cord-010119-t1x9gknd 12497 27 Director Director NNP cord-010119-t1x9gknd 12497 28 and and CC cord-010119-t1x9gknd 12497 29 the the DT cord-010119-t1x9gknd 12497 30 Transfusion Transfusion NNP cord-010119-t1x9gknd 12497 31 Safety Safety NNP cord-010119-t1x9gknd 12497 32 Officer Officer NNP cord-010119-t1x9gknd 12497 33 that that WDT cord-010119-t1x9gknd 12497 34 results result NNS cord-010119-t1x9gknd 12497 35 were be VBD cord-010119-t1x9gknd 12497 36 available available JJ cord-010119-t1x9gknd 12497 37 . . . cord-010119-t1x9gknd 12498 1 Results/ Results/ . cord-010119-t1x9gknd 12499 1 Findings finding NNS cord-010119-t1x9gknd 12499 2 : : : cord-010119-t1x9gknd 12500 1 Data datum NNS cord-010119-t1x9gknd 12500 2 was be VBD cord-010119-t1x9gknd 12500 3 collected collect VBN cord-010119-t1x9gknd 12500 4 for for IN cord-010119-t1x9gknd 12500 5 7 7 CD cord-010119-t1x9gknd 12500 6 months month NNS cord-010119-t1x9gknd 12500 7 following follow VBG cord-010119-t1x9gknd 12500 8 the the DT cord-010119-t1x9gknd 12500 9 implementation implementation NN cord-010119-t1x9gknd 12500 10 of of IN cord-010119-t1x9gknd 12500 11 this this DT cord-010119-t1x9gknd 12500 12 report report NN cord-010119-t1x9gknd 12500 13 and and CC cord-010119-t1x9gknd 12500 14 it -PRON- PRP cord-010119-t1x9gknd 12500 15 was be VBD cord-010119-t1x9gknd 12500 16 noted note VBN cord-010119-t1x9gknd 12500 17 that that IN cord-010119-t1x9gknd 12500 18 timeliness timeliness NN cord-010119-t1x9gknd 12500 19 of of IN cord-010119-t1x9gknd 12500 20 finalized finalize VBN cord-010119-t1x9gknd 12500 21 product product NN cord-010119-t1x9gknd 12500 22 culture culture NN cord-010119-t1x9gknd 12500 23 results result NNS cord-010119-t1x9gknd 12500 24 being be VBG cord-010119-t1x9gknd 12500 25 entered enter VBN cord-010119-t1x9gknd 12500 26 into into IN cord-010119-t1x9gknd 12500 27 the the DT cord-010119-t1x9gknd 12500 28 patient patient NN cord-010119-t1x9gknd 12500 29 's 's POS cord-010119-t1x9gknd 12500 30 EMR EMR NNP cord-010119-t1x9gknd 12500 31 improved improve VBD cord-010119-t1x9gknd 12500 32 to to IN cord-010119-t1x9gknd 12500 33 a a DT cord-010119-t1x9gknd 12500 34 range range NN cord-010119-t1x9gknd 12500 35 of of IN cord-010119-t1x9gknd 12500 36 0 0 CD cord-010119-t1x9gknd 12500 37 - - SYM cord-010119-t1x9gknd 12500 38 7 7 CD cord-010119-t1x9gknd 12500 39 days day NNS cord-010119-t1x9gknd 12500 40 with with IN cord-010119-t1x9gknd 12500 41 a a DT cord-010119-t1x9gknd 12500 42 mean mean NN cord-010119-t1x9gknd 12500 43 of of IN cord-010119-t1x9gknd 12500 44 2 2 CD cord-010119-t1x9gknd 12500 45 days day NNS cord-010119-t1x9gknd 12500 46 . . . cord-010119-t1x9gknd 12501 1 Conclusion conclusion NN cord-010119-t1x9gknd 12501 2 : : : cord-010119-t1x9gknd 12502 1 Improvements improvement NNS cord-010119-t1x9gknd 12502 2 in in IN cord-010119-t1x9gknd 12502 3 patient patient NN cord-010119-t1x9gknd 12502 4 care care NN cord-010119-t1x9gknd 12502 5 require require VBP cord-010119-t1x9gknd 12502 6 diligence diligence NN cord-010119-t1x9gknd 12502 7 and and CC cord-010119-t1x9gknd 12502 8 timely timely JJ cord-010119-t1x9gknd 12502 9 reporting reporting NN cord-010119-t1x9gknd 12502 10 of of IN cord-010119-t1x9gknd 12502 11 finalized finalize VBN cord-010119-t1x9gknd 12502 12 culture culture NN cord-010119-t1x9gknd 12502 13 reports report NNS cord-010119-t1x9gknd 12502 14 to to TO cord-010119-t1x9gknd 12502 15 determine determine VB cord-010119-t1x9gknd 12502 16 potential potential JJ cord-010119-t1x9gknd 12502 17 causes cause NNS cord-010119-t1x9gknd 12502 18 of of IN cord-010119-t1x9gknd 12502 19 transfusion transfusion NN cord-010119-t1x9gknd 12502 20 reactions reaction NNS cord-010119-t1x9gknd 12502 21 . . . cord-010119-t1x9gknd 12503 1 This this DT cord-010119-t1x9gknd 12503 2 process process NN cord-010119-t1x9gknd 12503 3 can can MD cord-010119-t1x9gknd 12503 4 be be VB cord-010119-t1x9gknd 12503 5 made make VBN cord-010119-t1x9gknd 12503 6 easier easy JJR cord-010119-t1x9gknd 12503 7 when when WRB cord-010119-t1x9gknd 12503 8 the the DT cord-010119-t1x9gknd 12503 9 correct correct JJ cord-010119-t1x9gknd 12503 10 tools tool NNS cord-010119-t1x9gknd 12503 11 are be VBP cord-010119-t1x9gknd 12503 12 used use VBN cord-010119-t1x9gknd 12503 13 . . . cord-010119-t1x9gknd 12504 1 Omer Omer NNP cord-010119-t1x9gknd 12504 2 Ilyas Ilyas NNP cord-010119-t1x9gknd 12504 3 * * NFP cord-010119-t1x9gknd 12504 4 1 1 CD cord-010119-t1x9gknd 12504 5 and and CC cord-010119-t1x9gknd 12504 6 Randy Randy NNP cord-010119-t1x9gknd 12504 7 Levine Levine NNP cord-010119-t1x9gknd 12504 8 2 2 CD cord-010119-t1x9gknd 12504 9 . . . cord-010119-t1x9gknd 12505 1 1 1 LS cord-010119-t1x9gknd 12506 1 Northwell Northwell NNP cord-010119-t1x9gknd 12506 2 Health Health NNP cord-010119-t1x9gknd 12506 3 , , , cord-010119-t1x9gknd 12506 4 2 2 CD cord-010119-t1x9gknd 12506 5 Lenox Lenox NNP cord-010119-t1x9gknd 12506 6 Hill Hill NNP cord-010119-t1x9gknd 12506 7 Hospital Hospital NNP cord-010119-t1x9gknd 12506 8 Background Background NNP cord-010119-t1x9gknd 12506 9 / / SYM cord-010119-t1x9gknd 12506 10 Case Case NNP cord-010119-t1x9gknd 12506 11 Studies Studies NNPS cord-010119-t1x9gknd 12506 12 : : : cord-010119-t1x9gknd 12506 13 Transfusion transfusion NN cord-010119-t1x9gknd 12506 14 of of IN cord-010119-t1x9gknd 12506 15 non non JJ cord-010119-t1x9gknd 12506 16 - - JJ cord-010119-t1x9gknd 12506 17 irradiated irradiated JJ cord-010119-t1x9gknd 12506 18 blood blood NN cord-010119-t1x9gknd 12506 19 in in IN cord-010119-t1x9gknd 12506 20 patients patient NNS cord-010119-t1x9gknd 12506 21 with with IN cord-010119-t1x9gknd 12506 22 hematologic hematologic JJ cord-010119-t1x9gknd 12506 23 malignancies malignancy NNS cord-010119-t1x9gknd 12506 24 and and CC cord-010119-t1x9gknd 12506 25 those those DT cord-010119-t1x9gknd 12506 26 receiving receive VBG cord-010119-t1x9gknd 12506 27 cytotoxic cytotoxic JJ cord-010119-t1x9gknd 12506 28 chemotherapy chemotherapy NN cord-010119-t1x9gknd 12506 29 can can MD cord-010119-t1x9gknd 12506 30 result result VB cord-010119-t1x9gknd 12506 31 in in IN cord-010119-t1x9gknd 12506 32 life life NN cord-010119-t1x9gknd 12506 33 - - HYPH cord-010119-t1x9gknd 12506 34 threatening threaten VBG cord-010119-t1x9gknd 12506 35 Graft graft NN cord-010119-t1x9gknd 12506 36 Versus Versus NNP cord-010119-t1x9gknd 12506 37 Host Host NNP cord-010119-t1x9gknd 12506 38 Disease Disease NNP cord-010119-t1x9gknd 12506 39 ( ( -LRB- cord-010119-t1x9gknd 12506 40 GVHD GVHD NNP cord-010119-t1x9gknd 12506 41 ) ) -RRB- cord-010119-t1x9gknd 12506 42 . . . cord-010119-t1x9gknd 12507 1 After after IN cord-010119-t1x9gknd 12507 2 noting note VBG cord-010119-t1x9gknd 12507 3 several several JJ cord-010119-t1x9gknd 12507 4 instances instance NNS cord-010119-t1x9gknd 12507 5 where where WRB cord-010119-t1x9gknd 12507 6 non non JJ cord-010119-t1x9gknd 12507 7 - - JJ cord-010119-t1x9gknd 12507 8 irradiated irradiated JJ cord-010119-t1x9gknd 12507 9 blood blood NN cord-010119-t1x9gknd 12507 10 was be VBD cord-010119-t1x9gknd 12507 11 transfused transfuse VBN cord-010119-t1x9gknd 12507 12 in in IN cord-010119-t1x9gknd 12507 13 patients patient NNS cord-010119-t1x9gknd 12507 14 requiring require VBG cord-010119-t1x9gknd 12507 15 irradiated irradiate VBN cord-010119-t1x9gknd 12507 16 blood blood NN cord-010119-t1x9gknd 12507 17 , , , cord-010119-t1x9gknd 12507 18 we -PRON- PRP cord-010119-t1x9gknd 12507 19 designed design VBD cord-010119-t1x9gknd 12507 20 a a DT cord-010119-t1x9gknd 12507 21 quality quality NN cord-010119-t1x9gknd 12507 22 improvement improvement NN cord-010119-t1x9gknd 12507 23 project project NN cord-010119-t1x9gknd 12507 24 with with IN cord-010119-t1x9gknd 12507 25 educational educational JJ cord-010119-t1x9gknd 12507 26 sessions session NNS cord-010119-t1x9gknd 12507 27 involving involve VBG cord-010119-t1x9gknd 12507 28 the the DT cord-010119-t1x9gknd 12507 29 oncology oncology NN cord-010119-t1x9gknd 12507 30 unit unit NN cord-010119-t1x9gknd 12507 31 and and CC cord-010119-t1x9gknd 12507 32 blood blood NN cord-010119-t1x9gknd 12507 33 bank bank NN cord-010119-t1x9gknd 12507 34 . . . cord-010119-t1x9gknd 12508 1 Study Study NNP cord-010119-t1x9gknd 12508 2 Design Design NNP cord-010119-t1x9gknd 12508 3 / / SYM cord-010119-t1x9gknd 12508 4 Method method NN cord-010119-t1x9gknd 12508 5 : : : cord-010119-t1x9gknd 12508 6 The the DT cord-010119-t1x9gknd 12508 7 project project NN cord-010119-t1x9gknd 12508 8 was be VBD cord-010119-t1x9gknd 12508 9 separated separate VBN cord-010119-t1x9gknd 12508 10 into into IN cord-010119-t1x9gknd 12508 11 three three CD cord-010119-t1x9gknd 12508 12 parts part NNS cord-010119-t1x9gknd 12508 13 . . . cord-010119-t1x9gknd 12509 1 In in IN cord-010119-t1x9gknd 12509 2 the the DT cord-010119-t1x9gknd 12509 3 first first JJ cord-010119-t1x9gknd 12509 4 part part NN cord-010119-t1x9gknd 12509 5 , , , cord-010119-t1x9gknd 12509 6 data datum NNS cord-010119-t1x9gknd 12509 7 on on IN cord-010119-t1x9gknd 12509 8 transfusion transfusion NN cord-010119-t1x9gknd 12509 9 practices practice NNS cord-010119-t1x9gknd 12509 10 was be VBD cord-010119-t1x9gknd 12509 11 retrospectively retrospectively RB cord-010119-t1x9gknd 12509 12 collected collect VBN cord-010119-t1x9gknd 12509 13 over over IN cord-010119-t1x9gknd 12509 14 a a DT cord-010119-t1x9gknd 12509 15 four four CD cord-010119-t1x9gknd 12509 16 month month NN cord-010119-t1x9gknd 12509 17 period period NN cord-010119-t1x9gknd 12509 18 on on IN cord-010119-t1x9gknd 12509 19 the the DT cord-010119-t1x9gknd 12509 20 oncology oncology NN cord-010119-t1x9gknd 12509 21 unit unit NN cord-010119-t1x9gknd 12509 22 . . . cord-010119-t1x9gknd 12510 1 The the DT cord-010119-t1x9gknd 12510 2 variables variable NNS cord-010119-t1x9gknd 12510 3 collected collect VBD cord-010119-t1x9gknd 12510 4 included include VBN cord-010119-t1x9gknd 12510 5 date date NN cord-010119-t1x9gknd 12510 6 and and CC cord-010119-t1x9gknd 12510 7 time time NN cord-010119-t1x9gknd 12510 8 of of IN cord-010119-t1x9gknd 12510 9 transfusion transfusion NN cord-010119-t1x9gknd 12510 10 , , , cord-010119-t1x9gknd 12510 11 pre pre VBN cord-010119-t1x9gknd 12510 12 - - JJ cord-010119-t1x9gknd 12510 13 and and CC cord-010119-t1x9gknd 12510 14 post post JJ cord-010119-t1x9gknd 12510 15 - - JJ cord-010119-t1x9gknd 12510 16 transfusion transfusion JJ cord-010119-t1x9gknd 12510 17 hemoglobin hemoglobin NN cord-010119-t1x9gknd 12510 18 , , , cord-010119-t1x9gknd 12510 19 patient patient JJ cord-010119-t1x9gknd 12510 20 diagnoses diagnosis NNS cord-010119-t1x9gknd 12510 21 , , , cord-010119-t1x9gknd 12510 22 and and CC cord-010119-t1x9gknd 12510 23 whether whether IN cord-010119-t1x9gknd 12510 24 or or CC cord-010119-t1x9gknd 12510 25 not not RB cord-010119-t1x9gknd 12510 26 blood blood NN cord-010119-t1x9gknd 12510 27 was be VBD cord-010119-t1x9gknd 12510 28 ordered order VBN cord-010119-t1x9gknd 12510 29 to to TO cord-010119-t1x9gknd 12510 30 be be VB cord-010119-t1x9gknd 12510 31 irradiated irradiate VBN cord-010119-t1x9gknd 12510 32 and and CC cord-010119-t1x9gknd 12510 33 if if IN cord-010119-t1x9gknd 12510 34 so so RB cord-010119-t1x9gknd 12510 35 , , , cord-010119-t1x9gknd 12510 36 whether whether IN cord-010119-t1x9gknd 12510 37 or or CC cord-010119-t1x9gknd 12510 38 not not RB cord-010119-t1x9gknd 12510 39 irradiated irradiate VBN cord-010119-t1x9gknd 12510 40 blood blood NN cord-010119-t1x9gknd 12510 41 was be VBD cord-010119-t1x9gknd 12510 42 issued issue VBN cord-010119-t1x9gknd 12510 43 by by IN cord-010119-t1x9gknd 12510 44 the the DT cord-010119-t1x9gknd 12510 45 blood blood NN cord-010119-t1x9gknd 12510 46 bank bank NN cord-010119-t1x9gknd 12510 47 . . . cord-010119-t1x9gknd 12511 1 All all DT cord-010119-t1x9gknd 12511 2 patients patient NNS cord-010119-t1x9gknd 12511 3 with with IN cord-010119-t1x9gknd 12511 4 hematological hematological JJ cord-010119-t1x9gknd 12511 5 malignancies malignancy NNS cord-010119-t1x9gknd 12511 6 and and CC cord-010119-t1x9gknd 12511 7 all all DT cord-010119-t1x9gknd 12511 8 patients patient NNS cord-010119-t1x9gknd 12511 9 receiving receive VBG cord-010119-t1x9gknd 12511 10 cytotoxic cytotoxic JJ cord-010119-t1x9gknd 12511 11 chemotherapy chemotherapy NN cord-010119-t1x9gknd 12511 12 were be VBD cord-010119-t1x9gknd 12511 13 candidates candidate NNS cord-010119-t1x9gknd 12511 14 for for IN cord-010119-t1x9gknd 12511 15 irradiated irradiate VBN cord-010119-t1x9gknd 12511 16 blood blood NN cord-010119-t1x9gknd 12511 17 . . . cord-010119-t1x9gknd 12512 1 The the DT cord-010119-t1x9gknd 12512 2 second second JJ cord-010119-t1x9gknd 12512 3 part part NN cord-010119-t1x9gknd 12512 4 of of IN cord-010119-t1x9gknd 12512 5 this this DT cord-010119-t1x9gknd 12512 6 project project NN cord-010119-t1x9gknd 12512 7 was be VBD cord-010119-t1x9gknd 12512 8 an an DT cord-010119-t1x9gknd 12512 9 educational educational JJ cord-010119-t1x9gknd 12512 10 intervention intervention NN cord-010119-t1x9gknd 12512 11 . . . cord-010119-t1x9gknd 12513 1 Residents resident NNS cord-010119-t1x9gknd 12513 2 , , , cord-010119-t1x9gknd 12513 3 oncology oncology NN cord-010119-t1x9gknd 12513 4 floor floor NN cord-010119-t1x9gknd 12513 5 nurses nurse NNS cord-010119-t1x9gknd 12513 6 , , , cord-010119-t1x9gknd 12513 7 and and CC cord-010119-t1x9gknd 12513 8 blood blood NN cord-010119-t1x9gknd 12513 9 bank bank NN cord-010119-t1x9gknd 12513 10 staff staff NN cord-010119-t1x9gknd 12513 11 were be VBD cord-010119-t1x9gknd 12513 12 given give VBN cord-010119-t1x9gknd 12513 13 lectures lecture NNS cord-010119-t1x9gknd 12513 14 on on IN cord-010119-t1x9gknd 12513 15 the the DT cord-010119-t1x9gknd 12513 16 importance importance NN cord-010119-t1x9gknd 12513 17 of of IN cord-010119-t1x9gknd 12513 18 transfusing transfuse VBG cord-010119-t1x9gknd 12513 19 irradiated irradiate VBN cord-010119-t1x9gknd 12513 20 blood blood NN cord-010119-t1x9gknd 12513 21 on on IN cord-010119-t1x9gknd 12513 22 the the DT cord-010119-t1x9gknd 12513 23 oncology oncology NN cord-010119-t1x9gknd 12513 24 floor floor NN cord-010119-t1x9gknd 12513 25 . . . cord-010119-t1x9gknd 12514 1 Residents resident NNS cord-010119-t1x9gknd 12514 2 were be VBD cord-010119-t1x9gknd 12514 3 also also RB cord-010119-t1x9gknd 12514 4 instructed instruct VBN cord-010119-t1x9gknd 12514 5 to to TO cord-010119-t1x9gknd 12514 6 order order VB cord-010119-t1x9gknd 12514 7 irradiated irradiate VBN cord-010119-t1x9gknd 12514 8 blood blood NN cord-010119-t1x9gknd 12514 9 for for IN cord-010119-t1x9gknd 12514 10 all all DT cord-010119-t1x9gknd 12514 11 patients patient NNS cord-010119-t1x9gknd 12514 12 on on IN cord-010119-t1x9gknd 12514 13 the the DT cord-010119-t1x9gknd 12514 14 oncology oncology NN cord-010119-t1x9gknd 12514 15 unit unit NN cord-010119-t1x9gknd 12514 16 . . . cord-010119-t1x9gknd 12515 1 In in IN cord-010119-t1x9gknd 12515 2 the the DT cord-010119-t1x9gknd 12515 3 third third JJ cord-010119-t1x9gknd 12515 4 part part NN cord-010119-t1x9gknd 12515 5 of of IN cord-010119-t1x9gknd 12515 6 this this DT cord-010119-t1x9gknd 12515 7 project project NN cord-010119-t1x9gknd 12515 8 , , , cord-010119-t1x9gknd 12515 9 repeat repeat VB cord-010119-t1x9gknd 12515 10 data datum NNS cord-010119-t1x9gknd 12515 11 was be VBD cord-010119-t1x9gknd 12515 12 collected collect VBN cord-010119-t1x9gknd 12515 13 over over IN cord-010119-t1x9gknd 12515 14 a a DT cord-010119-t1x9gknd 12515 15 two two CD cord-010119-t1x9gknd 12515 16 month month NN cord-010119-t1x9gknd 12515 17 period period NN cord-010119-t1x9gknd 12515 18 to to TO cord-010119-t1x9gknd 12515 19 assess assess VB cord-010119-t1x9gknd 12515 20 whether whether IN cord-010119-t1x9gknd 12515 21 the the DT cord-010119-t1x9gknd 12515 22 intervention intervention NN cord-010119-t1x9gknd 12515 23 was be VBD cord-010119-t1x9gknd 12515 24 successful successful JJ cord-010119-t1x9gknd 12515 25 . . . cord-010119-t1x9gknd 12516 1 Results/ Results/ . cord-010119-t1x9gknd 12517 1 Finding finding NN cord-010119-t1x9gknd 12517 2 : : : cord-010119-t1x9gknd 12518 1 Pre pre JJ cord-010119-t1x9gknd 12518 2 - - NN cord-010119-t1x9gknd 12518 3 intervention intervention NN cord-010119-t1x9gknd 12518 4 , , , cord-010119-t1x9gknd 12518 5 67 67 CD cord-010119-t1x9gknd 12518 6 units unit NNS cord-010119-t1x9gknd 12518 7 were be VBD cord-010119-t1x9gknd 12518 8 transfused transfuse VBN cord-010119-t1x9gknd 12518 9 on on IN cord-010119-t1x9gknd 12518 10 the the DT cord-010119-t1x9gknd 12518 11 oncology oncology NN cord-010119-t1x9gknd 12518 12 floor floor NN cord-010119-t1x9gknd 12518 13 with with IN cord-010119-t1x9gknd 12518 14 38 38 CD cord-010119-t1x9gknd 12518 15 units unit NNS cord-010119-t1x9gknd 12518 16 ( ( -LRB- cord-010119-t1x9gknd 12518 17 57 57 CD cord-010119-t1x9gknd 12518 18 % % NN cord-010119-t1x9gknd 12518 19 ) ) -RRB- cord-010119-t1x9gknd 12518 20 requiring require VBG cord-010119-t1x9gknd 12518 21 irradiation irradiation NN cord-010119-t1x9gknd 12518 22 and and CC cord-010119-t1x9gknd 12518 23 only only RB cord-010119-t1x9gknd 12518 24 22 22 CD cord-010119-t1x9gknd 12518 25 of of IN cord-010119-t1x9gknd 12518 26 those those DT cord-010119-t1x9gknd 12518 27 38 38 CD cord-010119-t1x9gknd 12518 28 units unit NNS cord-010119-t1x9gknd 12518 29 ( ( -LRB- cord-010119-t1x9gknd 12518 30 57 57 CD cord-010119-t1x9gknd 12518 31 % % NN cord-010119-t1x9gknd 12518 32 ) ) -RRB- cord-010119-t1x9gknd 12518 33 ordered order VBN cord-010119-t1x9gknd 12518 34 as as IN cord-010119-t1x9gknd 12518 35 irradiated irradiate VBN cord-010119-t1x9gknd 12518 36 . . . cord-010119-t1x9gknd 12519 1 Since since IN cord-010119-t1x9gknd 12519 2 the the DT cord-010119-t1x9gknd 12519 3 blood blood NN cord-010119-t1x9gknd 12519 4 bank bank NN cord-010119-t1x9gknd 12519 5 occasionally occasionally RB cord-010119-t1x9gknd 12519 6 issues issue VBZ cord-010119-t1x9gknd 12519 7 irradiated irradiate VBD cord-010119-t1x9gknd 12519 8 blood blood NN cord-010119-t1x9gknd 12519 9 without without IN cord-010119-t1x9gknd 12519 10 a a DT cord-010119-t1x9gknd 12519 11 specific specific JJ cord-010119-t1x9gknd 12519 12 order order NN cord-010119-t1x9gknd 12519 13 , , , cord-010119-t1x9gknd 12519 14 9 9 CD cord-010119-t1x9gknd 12519 15 additional additional JJ cord-010119-t1x9gknd 12519 16 irradiated irradiate VBN cord-010119-t1x9gknd 12519 17 units unit NNS cord-010119-t1x9gknd 12519 18 were be VBD cord-010119-t1x9gknd 12519 19 issued issue VBN cord-010119-t1x9gknd 12519 20 ( ( -LRB- cord-010119-t1x9gknd 12519 21 31/67 31/67 CD cord-010119-t1x9gknd 12519 22 ; ; : cord-010119-t1x9gknd 12519 23 46 46 CD cord-010119-t1x9gknd 12519 24 % % NN cord-010119-t1x9gknd 12519 25 ) ) -RRB- cord-010119-t1x9gknd 12519 26 . . . cord-010119-t1x9gknd 12520 1 Post post NN cord-010119-t1x9gknd 12520 2 - - NN cord-010119-t1x9gknd 12520 3 intervention intervention NN cord-010119-t1x9gknd 12520 4 , , , cord-010119-t1x9gknd 12520 5 29 29 CD cord-010119-t1x9gknd 12520 6 units unit NNS cord-010119-t1x9gknd 12520 7 were be VBD cord-010119-t1x9gknd 12520 8 transfused transfuse VBN cord-010119-t1x9gknd 12520 9 on on IN cord-010119-t1x9gknd 12520 10 the the DT cord-010119-t1x9gknd 12520 11 oncology oncology NN cord-010119-t1x9gknd 12520 12 floor floor NN cord-010119-t1x9gknd 12520 13 with with IN cord-010119-t1x9gknd 12520 14 15 15 CD cord-010119-t1x9gknd 12520 15 units unit NNS cord-010119-t1x9gknd 12520 16 ( ( -LRB- cord-010119-t1x9gknd 12520 17 52 52 CD cord-010119-t1x9gknd 12520 18 % % NN cord-010119-t1x9gknd 12520 19 ) ) -RRB- cord-010119-t1x9gknd 12520 20 requiring require VBG cord-010119-t1x9gknd 12520 21 irradiation irradiation NN cord-010119-t1x9gknd 12520 22 and and CC cord-010119-t1x9gknd 12520 23 all all DT cord-010119-t1x9gknd 12520 24 15 15 CD cord-010119-t1x9gknd 12520 25 of of IN cord-010119-t1x9gknd 12520 26 those those DT cord-010119-t1x9gknd 12520 27 units unit NNS cord-010119-t1x9gknd 12520 28 ( ( -LRB- cord-010119-t1x9gknd 12520 29 100 100 CD cord-010119-t1x9gknd 12520 30 % % NN cord-010119-t1x9gknd 12520 31 ) ) -RRB- cord-010119-t1x9gknd 12520 32 ordered order VBN cord-010119-t1x9gknd 12520 33 irradiated irradiate VBN cord-010119-t1x9gknd 12520 34 specifically specifically RB cord-010119-t1x9gknd 12520 35 to to TO cord-010119-t1x9gknd 12520 36 prevent prevent VB cord-010119-t1x9gknd 12520 37 GVHD GVHD NNP cord-010119-t1x9gknd 12520 38 . . . cord-010119-t1x9gknd 12521 1 Eight eight CD cord-010119-t1x9gknd 12521 2 additional additional JJ cord-010119-t1x9gknd 12521 3 irradiated irradiate VBN cord-010119-t1x9gknd 12521 4 units unit NNS cord-010119-t1x9gknd 12521 5 were be VBD cord-010119-t1x9gknd 12521 6 ordered order VBN cord-010119-t1x9gknd 12521 7 with with IN cord-010119-t1x9gknd 12521 8 no no DT cord-010119-t1x9gknd 12521 9 requirement requirement NN cord-010119-t1x9gknd 12521 10 for for IN cord-010119-t1x9gknd 12521 11 irradiation irradiation NN cord-010119-t1x9gknd 12521 12 ; ; : cord-010119-t1x9gknd 12521 13 thus thus RB cord-010119-t1x9gknd 12521 14 23 23 CD cord-010119-t1x9gknd 12521 15 of of IN cord-010119-t1x9gknd 12521 16 the the DT cord-010119-t1x9gknd 12521 17 29 29 CD cord-010119-t1x9gknd 12521 18 ( ( -LRB- cord-010119-t1x9gknd 12521 19 79 79 CD cord-010119-t1x9gknd 12521 20 % % NN cord-010119-t1x9gknd 12521 21 ) ) -RRB- cord-010119-t1x9gknd 12521 22 total total JJ cord-010119-t1x9gknd 12521 23 units unit NNS cord-010119-t1x9gknd 12521 24 were be VBD cord-010119-t1x9gknd 12521 25 ordered order VBN cord-010119-t1x9gknd 12521 26 as as IN cord-010119-t1x9gknd 12521 27 irradiated irradiate VBN cord-010119-t1x9gknd 12521 28 . . . cord-010119-t1x9gknd 12522 1 Again again RB cord-010119-t1x9gknd 12522 2 , , , cord-010119-t1x9gknd 12522 3 4 4 CD cord-010119-t1x9gknd 12522 4 additional additional JJ cord-010119-t1x9gknd 12522 5 irradiated irradiate VBN cord-010119-t1x9gknd 12522 6 units unit NNS cord-010119-t1x9gknd 12522 7 were be VBD cord-010119-t1x9gknd 12522 8 issued issue VBN cord-010119-t1x9gknd 12522 9 ( ( -LRB- cord-010119-t1x9gknd 12522 10 27/29;93 27/29;93 CD cord-010119-t1x9gknd 12522 11 % % NN cord-010119-t1x9gknd 12522 12 ) ) -RRB- cord-010119-t1x9gknd 12522 13 without without IN cord-010119-t1x9gknd 12522 14 a a DT cord-010119-t1x9gknd 12522 15 specific specific JJ cord-010119-t1x9gknd 12522 16 order order NN cord-010119-t1x9gknd 12522 17 by by IN cord-010119-t1x9gknd 12522 18 the the DT cord-010119-t1x9gknd 12522 19 blood blood NN cord-010119-t1x9gknd 12522 20 bank bank NN cord-010119-t1x9gknd 12522 21 . . . cord-010119-t1x9gknd 12523 1 The the DT cord-010119-t1x9gknd 12523 2 results result NNS cord-010119-t1x9gknd 12523 3 are be VBP cord-010119-t1x9gknd 12523 4 summarized summarize VBN cord-010119-t1x9gknd 12523 5 in in IN cord-010119-t1x9gknd 12523 6 the the DT cord-010119-t1x9gknd 12523 7 accompanying accompany VBG cord-010119-t1x9gknd 12523 8 table table NN cord-010119-t1x9gknd 12523 9 . . . cord-010119-t1x9gknd 12524 1 Conclusion conclusion NN cord-010119-t1x9gknd 12524 2 : : : cord-010119-t1x9gknd 12525 1 This this DT cord-010119-t1x9gknd 12525 2 quality quality NN cord-010119-t1x9gknd 12525 3 improvement improvement NN cord-010119-t1x9gknd 12525 4 project project NN cord-010119-t1x9gknd 12525 5 demonstrates demonstrate VBZ cord-010119-t1x9gknd 12525 6 that that IN cord-010119-t1x9gknd 12525 7 educational educational JJ cord-010119-t1x9gknd 12525 8 intervention intervention NN cord-010119-t1x9gknd 12525 9 can can MD cord-010119-t1x9gknd 12525 10 succeed succeed VB cord-010119-t1x9gknd 12525 11 in in IN cord-010119-t1x9gknd 12525 12 changing change VBG cord-010119-t1x9gknd 12525 13 clinical clinical JJ cord-010119-t1x9gknd 12525 14 practices practice NNS cord-010119-t1x9gknd 12525 15 . . . cord-010119-t1x9gknd 12526 1 Continued continue VBN cord-010119-t1x9gknd 12526 2 monitoring monitoring NN cord-010119-t1x9gknd 12526 3 of of IN cord-010119-t1x9gknd 12526 4 ordering order VBG cord-010119-t1x9gknd 12526 5 practices practice NNS cord-010119-t1x9gknd 12526 6 will will MD cord-010119-t1x9gknd 12526 7 ensure ensure VB cord-010119-t1x9gknd 12526 8 that that IN cord-010119-t1x9gknd 12526 9 compliance compliance NN cord-010119-t1x9gknd 12526 10 continues continue VBZ cord-010119-t1x9gknd 12526 11 . . . cord-010119-t1x9gknd 12527 1 We -PRON- PRP cord-010119-t1x9gknd 12527 2 plan plan VBP cord-010119-t1x9gknd 12527 3 to to TO cord-010119-t1x9gknd 12527 4 expand expand VB cord-010119-t1x9gknd 12527 5 the the DT cord-010119-t1x9gknd 12527 6 quality quality NN cord-010119-t1x9gknd 12527 7 improvement improvement NN cord-010119-t1x9gknd 12527 8 project project NN cord-010119-t1x9gknd 12527 9 to to IN cord-010119-t1x9gknd 12527 10 other other JJ cord-010119-t1x9gknd 12527 11 settings setting NNS cord-010119-t1x9gknd 12527 12 , , , cord-010119-t1x9gknd 12527 13 including include VBG cord-010119-t1x9gknd 12527 14 the the DT cord-010119-t1x9gknd 12527 15 emergency emergency NN cord-010119-t1x9gknd 12527 16 department department NN cord-010119-t1x9gknd 12527 17 and and CC cord-010119-t1x9gknd 12527 18 surgical surgical JJ cord-010119-t1x9gknd 12527 19 floors floor NNS cord-010119-t1x9gknd 12527 20 . . . cord-010119-t1x9gknd 12528 1 We -PRON- PRP cord-010119-t1x9gknd 12528 2 expect expect VBP cord-010119-t1x9gknd 12528 3 that that IN cord-010119-t1x9gknd 12528 4 adherence adherence NN cord-010119-t1x9gknd 12528 5 to to IN cord-010119-t1x9gknd 12528 6 transfusion transfusion NN cord-010119-t1x9gknd 12528 7 guidelines guideline NNS cord-010119-t1x9gknd 12528 8 in in IN cord-010119-t1x9gknd 12528 9 this this DT cord-010119-t1x9gknd 12528 10 patient patient JJ cord-010119-t1x9gknd 12528 11 population population NN cord-010119-t1x9gknd 12528 12 will will MD cord-010119-t1x9gknd 12528 13 reduce reduce VB cord-010119-t1x9gknd 12528 14 the the DT cord-010119-t1x9gknd 12528 15 incidence incidence NN cord-010119-t1x9gknd 12528 16 of of IN cord-010119-t1x9gknd 12528 17 adverse adverse JJ cord-010119-t1x9gknd 12528 18 events event NNS cord-010119-t1x9gknd 12528 19 . . . cord-010119-t1x9gknd 12529 1 Samantha Samantha NNP cord-010119-t1x9gknd 12529 2 Ngamsuntikul Ngamsuntikul NNP cord-010119-t1x9gknd 12529 3 * * NFP cord-010119-t1x9gknd 12529 4 1 1 CD cord-010119-t1x9gknd 12529 5 , , , cord-010119-t1x9gknd 12529 6 Charlotte Charlotte NNP cord-010119-t1x9gknd 12529 7 Van Van NNP cord-010119-t1x9gknd 12529 8 Dyke Dyke NNP cord-010119-t1x9gknd 12529 9 2 2 CD cord-010119-t1x9gknd 12529 10 , , , cord-010119-t1x9gknd 12529 11 Dina Dina NNP cord-010119-t1x9gknd 12529 12 Garza Garza NNP cord-010119-t1x9gknd 12529 13 Van Van NNP cord-010119-t1x9gknd 12529 14 Hoose Hoose NNP cord-010119-t1x9gknd 12529 15 2 2 CD cord-010119-t1x9gknd 12529 16 and and CC cord-010119-t1x9gknd 12529 17 Rachel Rachel NNP cord-010119-t1x9gknd 12529 18 Beddard Beddard NNP cord-010119-t1x9gknd 12529 19 1 1 CD cord-010119-t1x9gknd 12529 20 . . . cord-010119-t1x9gknd 12530 1 1 1 CD cord-010119-t1x9gknd 12530 2 BioBridge BioBridge NNP cord-010119-t1x9gknd 12530 3 Global Global NNP cord-010119-t1x9gknd 12530 4 , , , cord-010119-t1x9gknd 12530 5 2 2 CD cord-010119-t1x9gknd 12530 6 South South NNP cord-010119-t1x9gknd 12530 7 Texas Texas NNP cord-010119-t1x9gknd 12530 8 Blood Blood NNP cord-010119-t1x9gknd 12530 9 and and CC cord-010119-t1x9gknd 12530 10 Tissue Tissue NNP cord-010119-t1x9gknd 12530 11 Center Center NNP cord-010119-t1x9gknd 12530 12 Background Background NNP cord-010119-t1x9gknd 12530 13 / / SYM cord-010119-t1x9gknd 12530 14 Case Case NNP cord-010119-t1x9gknd 12530 15 Studies Studies NNPS cord-010119-t1x9gknd 12530 16 : : : cord-010119-t1x9gknd 12531 1 At at IN cord-010119-t1x9gknd 12531 2 our -PRON- PRP$ cord-010119-t1x9gknd 12531 3 blood blood NN cord-010119-t1x9gknd 12531 4 center center NN cord-010119-t1x9gknd 12531 5 , , , cord-010119-t1x9gknd 12531 6 apheresis apheresis NN cord-010119-t1x9gknd 12531 7 platelets platelet NNS cord-010119-t1x9gknd 12531 8 and and CC cord-010119-t1x9gknd 12531 9 red red JJ cord-010119-t1x9gknd 12531 10 cells cell NNS cord-010119-t1x9gknd 12531 11 are be VBP cord-010119-t1x9gknd 12531 12 collected collect VBN cord-010119-t1x9gknd 12531 13 on on IN cord-010119-t1x9gknd 12531 14 Trima Trima NNP cord-010119-t1x9gknd 12531 15 Accels Accels NNP cord-010119-t1x9gknd 12531 16 and and CC cord-010119-t1x9gknd 12531 17 double double JJ cord-010119-t1x9gknd 12531 18 red red JJ cord-010119-t1x9gknd 12531 19 cells cell NNS cord-010119-t1x9gknd 12531 20 on on IN cord-010119-t1x9gknd 12531 21 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 12531 22 8150s 8150s CD cord-010119-t1x9gknd 12531 23 . . . cord-010119-t1x9gknd 12532 1 In in IN cord-010119-t1x9gknd 12532 2 addition addition NN cord-010119-t1x9gknd 12532 3 to to IN cord-010119-t1x9gknd 12532 4 routine routine JJ cord-010119-t1x9gknd 12532 5 quality quality NN cord-010119-t1x9gknd 12532 6 control control NN cord-010119-t1x9gknd 12532 7 ( ( -LRB- cord-010119-t1x9gknd 12532 8 Qc Qc NNP cord-010119-t1x9gknd 12532 9 ) ) -RRB- cord-010119-t1x9gknd 12532 10 , , , cord-010119-t1x9gknd 12532 11 Qc Qc NNP cord-010119-t1x9gknd 12532 12 is be VBZ cord-010119-t1x9gknd 12532 13 performed perform VBN cord-010119-t1x9gknd 12532 14 for for IN cord-010119-t1x9gknd 12532 15 instrument instrument NN cord-010119-t1x9gknd 12532 16 flags flag NNS cord-010119-t1x9gknd 12532 17 on on IN cord-010119-t1x9gknd 12532 18 collection collection NN cord-010119-t1x9gknd 12532 19 instruments instrument NNS cord-010119-t1x9gknd 12532 20 . . . cord-010119-t1x9gknd 12533 1 Quality quality NN cord-010119-t1x9gknd 12533 2 control control NN cord-010119-t1x9gknd 12533 3 for for IN cord-010119-t1x9gknd 12533 4 apheresis apheresis NN cord-010119-t1x9gknd 12533 5 platelets platelet NNS cord-010119-t1x9gknd 12533 6 includes include VBZ cord-010119-t1x9gknd 12533 7 : : : cord-010119-t1x9gknd 12533 8 volume volume NN cord-010119-t1x9gknd 12533 9 variance variance NN cord-010119-t1x9gknd 12533 10 and and CC cord-010119-t1x9gknd 12533 11 rWBC rwbc JJ cord-010119-t1x9gknd 12533 12 ; ; : cord-010119-t1x9gknd 12533 13 quality quality NN cord-010119-t1x9gknd 12533 14 control control NN cord-010119-t1x9gknd 12533 15 for for IN cord-010119-t1x9gknd 12533 16 apheresis apheresis NN cord-010119-t1x9gknd 12533 17 red red NNP cord-010119-t1x9gknd 12533 18 cells cell NNS cord-010119-t1x9gknd 12533 19 includes include VBZ cord-010119-t1x9gknd 12533 20 : : : cord-010119-t1x9gknd 12533 21 product product NN cord-010119-t1x9gknd 12533 22 volume volume NN cord-010119-t1x9gknd 12533 23 , , , cord-010119-t1x9gknd 12533 24 volume volume NN cord-010119-t1x9gknd 12533 25 variance variance NN cord-010119-t1x9gknd 12533 26 , , , cord-010119-t1x9gknd 12533 27 hemoglobin hemoglobin NN cord-010119-t1x9gknd 12533 28 and and CC cord-010119-t1x9gknd 12533 29 red red JJ cord-010119-t1x9gknd 12533 30 blood blood NN cord-010119-t1x9gknd 12533 31 cell cell NN cord-010119-t1x9gknd 12533 32 mass mass NN cord-010119-t1x9gknd 12533 33 . . . cord-010119-t1x9gknd 12534 1 Study Study NNP cord-010119-t1x9gknd 12534 2 Design Design NNP cord-010119-t1x9gknd 12534 3 / / SYM cord-010119-t1x9gknd 12534 4 Methods method NNS cord-010119-t1x9gknd 12534 5 : : : cord-010119-t1x9gknd 12534 6 During during IN cord-010119-t1x9gknd 12534 7 the the DT cord-010119-t1x9gknd 12534 8 period period NN cord-010119-t1x9gknd 12534 9 of of IN cord-010119-t1x9gknd 12534 10 January January NNP cord-010119-t1x9gknd 12534 11 1 1 CD cord-010119-t1x9gknd 12534 12 , , , cord-010119-t1x9gknd 12534 13 2016 2016 CD cord-010119-t1x9gknd 12534 14 to to IN cord-010119-t1x9gknd 12534 15 April April NNP cord-010119-t1x9gknd 12534 16 19 19 CD cord-010119-t1x9gknd 12534 17 , , , cord-010119-t1x9gknd 12534 18 2017 2017 CD cord-010119-t1x9gknd 12534 19 , , , cord-010119-t1x9gknd 12534 20 2,097 2,097 CD cord-010119-t1x9gknd 12534 21 total total JJ cord-010119-t1x9gknd 12534 22 collections collection NNS cord-010119-t1x9gknd 12534 23 were be VBD cord-010119-t1x9gknd 12534 24 flagged flag VBN cord-010119-t1x9gknd 12534 25 for for IN cord-010119-t1x9gknd 12534 26 additional additional JJ cord-010119-t1x9gknd 12534 27 Qc Qc NNP cord-010119-t1x9gknd 12534 28 by by IN cord-010119-t1x9gknd 12534 29 our -PRON- PRP$ cord-010119-t1x9gknd 12534 30 Trima Trima NNP cord-010119-t1x9gknd 12534 31 Accels Accels NNP cord-010119-t1x9gknd 12534 32 and and CC cord-010119-t1x9gknd 12534 33 Haemonetics Haemonetics NNP cord-010119-t1x9gknd 12534 34 8150 8150 CD cord-010119-t1x9gknd 12534 35 instruments instrument NNS cord-010119-t1x9gknd 12534 36 . . . cord-010119-t1x9gknd 12535 1 Quality quality NN cord-010119-t1x9gknd 12535 2 control control NN cord-010119-t1x9gknd 12535 3 at at IN cord-010119-t1x9gknd 12535 4 our -PRON- PRP$ cord-010119-t1x9gknd 12535 5 center center NN cord-010119-t1x9gknd 12535 6 is be VBZ cord-010119-t1x9gknd 12535 7 tracked track VBN cord-010119-t1x9gknd 12535 8 by by IN cord-010119-t1x9gknd 12535 9 our -PRON- PRP$ cord-010119-t1x9gknd 12535 10 quality quality NN cord-010119-t1x9gknd 12535 11 control control NN cord-010119-t1x9gknd 12535 12 software software NN cord-010119-t1x9gknd 12535 13 management management NN cord-010119-t1x9gknd 12535 14 system system NN cord-010119-t1x9gknd 12535 15 , , , cord-010119-t1x9gknd 12535 16 HemaTerra HemaTerra NNP cord-010119-t1x9gknd 12535 17 's 's POS cord-010119-t1x9gknd 12535 18 HemaComply HemaComply NNP cord-010119-t1x9gknd 12535 19 which which WDT cord-010119-t1x9gknd 12535 20 allows allow VBZ cord-010119-t1x9gknd 12535 21 the the DT cord-010119-t1x9gknd 12535 22 ability ability NN cord-010119-t1x9gknd 12535 23 to to TO cord-010119-t1x9gknd 12535 24 track track VB cord-010119-t1x9gknd 12535 25 and and CC cord-010119-t1x9gknd 12535 26 retrieve retrieve VB cord-010119-t1x9gknd 12535 27 this this DT cord-010119-t1x9gknd 12535 28 information information NN cord-010119-t1x9gknd 12535 29 . . . cord-010119-t1x9gknd 12536 1 The the DT cord-010119-t1x9gknd 12536 2 majority majority NN cord-010119-t1x9gknd 12536 3 of of IN cord-010119-t1x9gknd 12536 4 products product NNS cord-010119-t1x9gknd 12536 5 flagged flag VBN cord-010119-t1x9gknd 12536 6 for for IN cord-010119-t1x9gknd 12536 7 instrument instrument NN cord-010119-t1x9gknd 12536 8 Qc Qc NNP cord-010119-t1x9gknd 12536 9 pass pass NN cord-010119-t1x9gknd 12536 10 and and CC cord-010119-t1x9gknd 12536 11 are be VBP cord-010119-t1x9gknd 12536 12 released release VBN cord-010119-t1x9gknd 12536 13 for for IN cord-010119-t1x9gknd 12536 14 distribution distribution NN cord-010119-t1x9gknd 12536 15 . . . cord-010119-t1x9gknd 12537 1 A a DT cord-010119-t1x9gknd 12537 2 small small JJ cord-010119-t1x9gknd 12537 3 percentage percentage NN cord-010119-t1x9gknd 12537 4 , , , cord-010119-t1x9gknd 12537 5 however however RB cord-010119-t1x9gknd 12537 6 do do VBP cord-010119-t1x9gknd 12537 7 fail fail VB cord-010119-t1x9gknd 12537 8 Qc Qc NNP cord-010119-t1x9gknd 12537 9 leading lead VBG cord-010119-t1x9gknd 12537 10 to to IN cord-010119-t1x9gknd 12537 11 loss loss NN cord-010119-t1x9gknd 12537 12 of of IN cord-010119-t1x9gknd 12537 13 product product NN cord-010119-t1x9gknd 12537 14 . . . cord-010119-t1x9gknd 12538 1 Quality quality NN cord-010119-t1x9gknd 12538 2 control control NN cord-010119-t1x9gknd 12538 3 data datum NNS cord-010119-t1x9gknd 12538 4 can can MD cord-010119-t1x9gknd 12538 5 be be VB cord-010119-t1x9gknd 12538 6 retrieved retrieve VBN cord-010119-t1x9gknd 12538 7 and and CC cord-010119-t1x9gknd 12538 8 monitored monitor VBN cord-010119-t1x9gknd 12538 9 for for IN cord-010119-t1x9gknd 12538 10 trends trend NNS cord-010119-t1x9gknd 12538 11 using use VBG cord-010119-t1x9gknd 12538 12 a a DT cord-010119-t1x9gknd 12538 13 quality quality NN cord-010119-t1x9gknd 12538 14 control control NN cord-010119-t1x9gknd 12538 15 software software NN cord-010119-t1x9gknd 12538 16 management management NN cord-010119-t1x9gknd 12538 17 system system NN cord-010119-t1x9gknd 12538 18 . . . cord-010119-t1x9gknd 12539 1 Background Background NNP cord-010119-t1x9gknd 12539 2 / / SYM cord-010119-t1x9gknd 12539 3 Case Case NNP cord-010119-t1x9gknd 12539 4 Studies Studies NNPS cord-010119-t1x9gknd 12539 5 : : : cord-010119-t1x9gknd 12540 1 In in IN cord-010119-t1x9gknd 12540 2 2015 2015 CD cord-010119-t1x9gknd 12540 3 , , , cord-010119-t1x9gknd 12540 4 The the DT cord-010119-t1x9gknd 12540 5 Centers Centers NNPS cord-010119-t1x9gknd 12540 6 for for IN cord-010119-t1x9gknd 12540 7 Medicare Medicare NNP cord-010119-t1x9gknd 12540 8 & & CC cord-010119-t1x9gknd 12540 9 Medicaid Medicaid NNP cord-010119-t1x9gknd 12540 10 Services Services NNP cord-010119-t1x9gknd 12540 11 ( ( -LRB- cord-010119-t1x9gknd 12540 12 CMS CMS NNP cord-010119-t1x9gknd 12540 13 ) ) -RRB- cord-010119-t1x9gknd 12540 14 rolled roll VBD cord-010119-t1x9gknd 12540 15 out out RP cord-010119-t1x9gknd 12540 16 a a DT cord-010119-t1x9gknd 12540 17 plan plan NN cord-010119-t1x9gknd 12540 18 for for IN cord-010119-t1x9gknd 12540 19 implementing implement VBG cord-010119-t1x9gknd 12540 20 IQCP IQCP NNP cord-010119-t1x9gknd 12540 21 ( ( -LRB- cord-010119-t1x9gknd 12540 22 Individualized Individualized NNP cord-010119-t1x9gknd 12540 23 Quality Quality NNP cord-010119-t1x9gknd 12540 24 Control Control NNP cord-010119-t1x9gknd 12540 25 Plan Plan NNP cord-010119-t1x9gknd 12540 26 ) ) -RRB- cord-010119-t1x9gknd 12540 27 as as IN cord-010119-t1x9gknd 12540 28 a a DT cord-010119-t1x9gknd 12540 29 new new JJ cord-010119-t1x9gknd 12540 30 quality quality NN cord-010119-t1x9gknd 12540 31 control control NN cord-010119-t1x9gknd 12540 32 option option NN cord-010119-t1x9gknd 12540 33 based base VBN cord-010119-t1x9gknd 12540 34 on on IN cord-010119-t1x9gknd 12540 35 a a DT cord-010119-t1x9gknd 12540 36 risk risk NN cord-010119-t1x9gknd 12540 37 management management NN cord-010119-t1x9gknd 12540 38 plan plan NN cord-010119-t1x9gknd 12540 39 for for IN cord-010119-t1x9gknd 12540 40 CLIA CLIA NNP cord-010119-t1x9gknd 12540 41 laboratories laboratory NNS cord-010119-t1x9gknd 12540 42 performing perform VBG cord-010119-t1x9gknd 12540 43 non non AFX cord-010119-t1x9gknd 12540 44 - - JJ cord-010119-t1x9gknd 12540 45 waived waive VBN cord-010119-t1x9gknd 12540 46 testing testing NN cord-010119-t1x9gknd 12540 47 . . . cord-010119-t1x9gknd 12541 1 This this DT cord-010119-t1x9gknd 12541 2 plan plan NN cord-010119-t1x9gknd 12541 3 was be VBD cord-010119-t1x9gknd 12541 4 meant mean VBN cord-010119-t1x9gknd 12541 5 for for IN cord-010119-t1x9gknd 12541 6 CLIA CLIA NNP cord-010119-t1x9gknd 12541 7 approved approve VBD cord-010119-t1x9gknd 12541 8 tests test NNS cord-010119-t1x9gknd 12541 9 , , , cord-010119-t1x9gknd 12541 10 but but CC cord-010119-t1x9gknd 12541 11 serves serve VBZ cord-010119-t1x9gknd 12541 12 as as IN cord-010119-t1x9gknd 12541 13 a a DT cord-010119-t1x9gknd 12541 14 good good JJ cord-010119-t1x9gknd 12541 15 tool tool NN cord-010119-t1x9gknd 12541 16 for for IN cord-010119-t1x9gknd 12541 17 labs lab NNS cord-010119-t1x9gknd 12541 18 performing perform VBG cord-010119-t1x9gknd 12541 19 non non JJ cord-010119-t1x9gknd 12541 20 - - JJ cord-010119-t1x9gknd 12541 21 traditional traditional JJ cord-010119-t1x9gknd 12541 22 and and CC cord-010119-t1x9gknd 12541 23 traditional traditional JJ cord-010119-t1x9gknd 12541 24 tests test NNS cord-010119-t1x9gknd 12541 25 on on IN cord-010119-t1x9gknd 12541 26 non non JJ cord-010119-t1x9gknd 12541 27 - - JJ cord-010119-t1x9gknd 12541 28 traditional traditional JJ cord-010119-t1x9gknd 12541 29 samples sample NNS cord-010119-t1x9gknd 12541 30 . . . cord-010119-t1x9gknd 12542 1 Study Study NNP cord-010119-t1x9gknd 12542 2 Design Design NNP cord-010119-t1x9gknd 12542 3 / / SYM cord-010119-t1x9gknd 12542 4 Method method NN cord-010119-t1x9gknd 12542 5 : : : cord-010119-t1x9gknd 12543 1 CLIA CLIA NNP cord-010119-t1x9gknd 12543 2 Clinical clinical JJ cord-010119-t1x9gknd 12543 3 laboratories laboratory NNS cord-010119-t1x9gknd 12543 4 can can MD cord-010119-t1x9gknd 12543 5 either either CC cord-010119-t1x9gknd 12543 6 follow follow VB cord-010119-t1x9gknd 12543 7 traditional traditional JJ cord-010119-t1x9gknd 12543 8 clinical clinical JJ cord-010119-t1x9gknd 12543 9 CLIA CLIA NNP cord-010119-t1x9gknd 12543 10 QC QC NNP cord-010119-t1x9gknd 12543 11 requirements requirement NNS cord-010119-t1x9gknd 12543 12 according accord VBG cord-010119-t1x9gknd 12543 13 to to IN cord-010119-t1x9gknd 12543 14 the the DT cord-010119-t1x9gknd 12543 15 regulations regulation NNS cord-010119-t1x9gknd 12543 16 or or CC cord-010119-t1x9gknd 12543 17 Implement implement VB cord-010119-t1x9gknd 12543 18 IQCP IQCP NNP cord-010119-t1x9gknd 12543 19 . . . cord-010119-t1x9gknd 12544 1 While while IN cord-010119-t1x9gknd 12544 2 we -PRON- PRP cord-010119-t1x9gknd 12544 3 perfrom perfrom VBP cord-010119-t1x9gknd 12544 4 traditional traditional JJ cord-010119-t1x9gknd 12544 5 QC QC NNP cord-010119-t1x9gknd 12544 6 assessments assessment NNS cord-010119-t1x9gknd 12544 7 on on IN cord-010119-t1x9gknd 12544 8 all all PDT cord-010119-t1x9gknd 12544 9 the the DT cord-010119-t1x9gknd 12544 10 tests test NNS cord-010119-t1x9gknd 12544 11 we -PRON- PRP cord-010119-t1x9gknd 12544 12 perfrom perfrom VBP cord-010119-t1x9gknd 12544 13 on on IN cord-010119-t1x9gknd 12544 14 our -PRON- PRP$ cord-010119-t1x9gknd 12544 15 cellular cellular JJ cord-010119-t1x9gknd 12544 16 products product NNS cord-010119-t1x9gknd 12544 17 we -PRON- PRP cord-010119-t1x9gknd 12544 18 did do VBD cord-010119-t1x9gknd 12544 19 decide decide VB cord-010119-t1x9gknd 12544 20 to to TO cord-010119-t1x9gknd 12544 21 implement implement VB cord-010119-t1x9gknd 12544 22 the the DT cord-010119-t1x9gknd 12544 23 IQCP IQCP NNP cord-010119-t1x9gknd 12544 24 program program NN cord-010119-t1x9gknd 12544 25 within within IN cord-010119-t1x9gknd 12544 26 in in IN cord-010119-t1x9gknd 12544 27 our -PRON- PRP$ cord-010119-t1x9gknd 12544 28 Quality Quality NNP cord-010119-t1x9gknd 12544 29 Control Control NNP cord-010119-t1x9gknd 12544 30 Laboratory Laboratory NNP cord-010119-t1x9gknd 12544 31 . . . cord-010119-t1x9gknd 12545 1 We -PRON- PRP cord-010119-t1x9gknd 12545 2 followed follow VBD cord-010119-t1x9gknd 12545 3 the the DT cord-010119-t1x9gknd 12545 4 IQCP IQCP NNP cord-010119-t1x9gknd 12545 5 process process NN cord-010119-t1x9gknd 12545 6 for for IN cord-010119-t1x9gknd 12545 7 assessing assess VBG cord-010119-t1x9gknd 12545 8 some some DT cord-010119-t1x9gknd 12545 9 of of IN cord-010119-t1x9gknd 12545 10 our -PRON- PRP$ cord-010119-t1x9gknd 12545 11 QC QC NNP cord-010119-t1x9gknd 12545 12 tests test NNS cord-010119-t1x9gknd 12545 13 used use VBN cord-010119-t1x9gknd 12545 14 to to TO cord-010119-t1x9gknd 12545 15 assess assess VB cord-010119-t1x9gknd 12545 16 the the DT cord-010119-t1x9gknd 12545 17 safety safety NN cord-010119-t1x9gknd 12545 18 , , , cord-010119-t1x9gknd 12545 19 purity purity NN cord-010119-t1x9gknd 12545 20 and and CC cord-010119-t1x9gknd 12545 21 potency potency NN cord-010119-t1x9gknd 12545 22 of of IN cord-010119-t1x9gknd 12545 23 our -PRON- PRP$ cord-010119-t1x9gknd 12545 24 cell cell NN cord-010119-t1x9gknd 12545 25 based base VBN cord-010119-t1x9gknd 12545 26 products product NNS cord-010119-t1x9gknd 12545 27 . . . cord-010119-t1x9gknd 12546 1 One one CD cord-010119-t1x9gknd 12546 2 test test NN cord-010119-t1x9gknd 12546 3 in in IN cord-010119-t1x9gknd 12546 4 particular particular JJ cord-010119-t1x9gknd 12546 5 where where WRB cord-010119-t1x9gknd 12546 6 we -PRON- PRP cord-010119-t1x9gknd 12546 7 applied apply VBD cord-010119-t1x9gknd 12546 8 this this DT cord-010119-t1x9gknd 12546 9 tool tool NN cord-010119-t1x9gknd 12546 10 was be VBD cord-010119-t1x9gknd 12546 11 in in IN cord-010119-t1x9gknd 12546 12 the the DT cord-010119-t1x9gknd 12546 13 review review NN cord-010119-t1x9gknd 12546 14 of of IN cord-010119-t1x9gknd 12546 15 our -PRON- PRP$ cord-010119-t1x9gknd 12546 16 QC QC NNP cord-010119-t1x9gknd 12546 17 sterility sterility NN cord-010119-t1x9gknd 12546 18 testing testing NN cord-010119-t1x9gknd 12546 19 method method NN cord-010119-t1x9gknd 12546 20 and and CC cord-010119-t1x9gknd 12546 21 found find VBD cord-010119-t1x9gknd 12546 22 it -PRON- PRP cord-010119-t1x9gknd 12546 23 to to TO cord-010119-t1x9gknd 12546 24 be be VB cord-010119-t1x9gknd 12546 25 a a DT cord-010119-t1x9gknd 12546 26 very very RB cord-010119-t1x9gknd 12546 27 useful useful JJ cord-010119-t1x9gknd 12546 28 in in IN cord-010119-t1x9gknd 12546 29 improving improve VBG cord-010119-t1x9gknd 12546 30 the the DT cord-010119-t1x9gknd 12546 31 overall overall JJ cord-010119-t1x9gknd 12546 32 process process NN cord-010119-t1x9gknd 12546 33 . . . cord-010119-t1x9gknd 12547 1 The the DT cord-010119-t1x9gknd 12547 2 tool tool NN cord-010119-t1x9gknd 12547 3 walks walk VBZ cord-010119-t1x9gknd 12547 4 you -PRON- PRP cord-010119-t1x9gknd 12547 5 through through IN cord-010119-t1x9gknd 12547 6 three three CD cord-010119-t1x9gknd 12547 7 process process NN cord-010119-t1x9gknd 12547 8 requirements requirement NNS cord-010119-t1x9gknd 12547 9 : : : cord-010119-t1x9gknd 12547 10 1 1 LS cord-010119-t1x9gknd 12547 11 ) ) -RRB- cord-010119-t1x9gknd 12547 12 Risk Risk NNP cord-010119-t1x9gknd 12547 13 Assessment Assessment NNP cord-010119-t1x9gknd 12547 14 , , , cord-010119-t1x9gknd 12547 15 2 2 CD cord-010119-t1x9gknd 12547 16 ) ) -RRB- cord-010119-t1x9gknd 12547 17 Quality Quality NNP cord-010119-t1x9gknd 12547 18 Control Control NNP cord-010119-t1x9gknd 12547 19 Plan Plan NNP cord-010119-t1x9gknd 12547 20 and and CC cord-010119-t1x9gknd 12547 21 3 3 CD cord-010119-t1x9gknd 12547 22 ) ) -RRB- cord-010119-t1x9gknd 12547 23 Quality Quality NNP cord-010119-t1x9gknd 12547 24 Assessment Assessment NNP cord-010119-t1x9gknd 12547 25 for for IN cord-010119-t1x9gknd 12547 26 the the DT cord-010119-t1x9gknd 12547 27 preanalytical preanalytical JJ cord-010119-t1x9gknd 12547 28 , , , cord-010119-t1x9gknd 12547 29 analytical analytical JJ cord-010119-t1x9gknd 12547 30 and and CC cord-010119-t1x9gknd 12547 31 post post JJ cord-010119-t1x9gknd 12547 32 analytical analytical JJ cord-010119-t1x9gknd 12547 33 phases phase NNS cord-010119-t1x9gknd 12547 34 of of IN cord-010119-t1x9gknd 12547 35 testing testing NN cord-010119-t1x9gknd 12547 36 . . . cord-010119-t1x9gknd 12548 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 12548 2 Conclusion conclusion NN cord-010119-t1x9gknd 12548 3 : : : cord-010119-t1x9gknd 12549 1 The the DT cord-010119-t1x9gknd 12549 2 integration integration NN cord-010119-t1x9gknd 12549 3 of of IN cord-010119-t1x9gknd 12549 4 the the DT cord-010119-t1x9gknd 12549 5 IQCP IQCP NNP cord-010119-t1x9gknd 12549 6 into into IN cord-010119-t1x9gknd 12549 7 the the DT cord-010119-t1x9gknd 12549 8 Quality Quality NNP cord-010119-t1x9gknd 12549 9 Control Control NNP cord-010119-t1x9gknd 12549 10 Laboratory Laboratory NNP cord-010119-t1x9gknd 12549 11 was be VBD cord-010119-t1x9gknd 12549 12 determined determine VBN cord-010119-t1x9gknd 12549 13 to to TO cord-010119-t1x9gknd 12549 14 be be VB cord-010119-t1x9gknd 12549 15 a a DT cord-010119-t1x9gknd 12549 16 success success NN cord-010119-t1x9gknd 12549 17 . . . cord-010119-t1x9gknd 12550 1 The the DT cord-010119-t1x9gknd 12550 2 IQCP IQCP NNP cord-010119-t1x9gknd 12550 3 tool tool NN cord-010119-t1x9gknd 12550 4 was be VBD cord-010119-t1x9gknd 12550 5 successful successful JJ cord-010119-t1x9gknd 12550 6 in in IN cord-010119-t1x9gknd 12550 7 identifying identify VBG cord-010119-t1x9gknd 12550 8 gaps gap NNS cord-010119-t1x9gknd 12550 9 within within IN cord-010119-t1x9gknd 12550 10 the the DT cord-010119-t1x9gknd 12550 11 sterility sterility NN cord-010119-t1x9gknd 12550 12 testing testing NN cord-010119-t1x9gknd 12550 13 process process NN cord-010119-t1x9gknd 12550 14 . . . cord-010119-t1x9gknd 12551 1 This this DT cord-010119-t1x9gknd 12551 2 tool tool NN cord-010119-t1x9gknd 12551 3 will will MD cord-010119-t1x9gknd 12551 4 be be VB cord-010119-t1x9gknd 12551 5 used use VBN cord-010119-t1x9gknd 12551 6 on on IN cord-010119-t1x9gknd 12551 7 additional additional JJ cord-010119-t1x9gknd 12551 8 quality quality NN cord-010119-t1x9gknd 12551 9 control control NN cord-010119-t1x9gknd 12551 10 tests test NNS cord-010119-t1x9gknd 12551 11 and and CC cord-010119-t1x9gknd 12551 12 manufacturing manufacturing NN cord-010119-t1x9gknd 12551 13 processes process NNS cord-010119-t1x9gknd 12551 14 . . . cord-010119-t1x9gknd 12552 1 The the DT cord-010119-t1x9gknd 12552 2 implementation implementation NN cord-010119-t1x9gknd 12552 3 of of IN cord-010119-t1x9gknd 12552 4 the the DT cord-010119-t1x9gknd 12552 5 IQCP IQCP NNP cord-010119-t1x9gknd 12552 6 program program NN cord-010119-t1x9gknd 12552 7 ensure ensure VB cord-010119-t1x9gknd 12552 8 regulatory regulatory JJ cord-010119-t1x9gknd 12552 9 QC QC NNP cord-010119-t1x9gknd 12552 10 requirements requirement NNS cord-010119-t1x9gknd 12552 11 appropriate appropriate JJ cord-010119-t1x9gknd 12552 12 for for IN cord-010119-t1x9gknd 12552 13 testing testing NN cord-010119-t1x9gknd 12552 14 performed perform VBN cord-010119-t1x9gknd 12552 15 . . . cord-010119-t1x9gknd 12553 1 We -PRON- PRP cord-010119-t1x9gknd 12553 2 were be VBD cord-010119-t1x9gknd 12553 3 able able JJ cord-010119-t1x9gknd 12553 4 to to TO cord-010119-t1x9gknd 12553 5 revise revise VB cord-010119-t1x9gknd 12553 6 our -PRON- PRP$ cord-010119-t1x9gknd 12553 7 procedures procedure NNS cord-010119-t1x9gknd 12553 8 , , , cord-010119-t1x9gknd 12553 9 reeducate reeducate VB cord-010119-t1x9gknd 12553 10 those those DT cord-010119-t1x9gknd 12553 11 involved involve VBN cord-010119-t1x9gknd 12553 12 in in IN cord-010119-t1x9gknd 12553 13 the the DT cord-010119-t1x9gknd 12553 14 process process NN cord-010119-t1x9gknd 12553 15 and and CC cord-010119-t1x9gknd 12553 16 hopefully hopefully RB cord-010119-t1x9gknd 12553 17 minimize minimize VB cord-010119-t1x9gknd 12553 18 potential potential JJ cord-010119-t1x9gknd 12553 19 sources source NNS cord-010119-t1x9gknd 12553 20 of of IN cord-010119-t1x9gknd 12553 21 error error NN cord-010119-t1x9gknd 12553 22 . . . cord-010119-t1x9gknd 12554 1 Objective Objective NNP cord-010119-t1x9gknd 12554 2 Performance Performance NNP cord-010119-t1x9gknd 12554 3 of of IN cord-010119-t1x9gknd 12554 4 Massive Massive NNP cord-010119-t1x9gknd 12554 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 12554 6 Protocols Protocols NNPS cord-010119-t1x9gknd 12554 7 at at IN cord-010119-t1x9gknd 12554 8 a a DT cord-010119-t1x9gknd 12554 9 Single Single NNP cord-010119-t1x9gknd 12554 10 Institution Institution NNP cord-010119-t1x9gknd 12554 11 Gustaaf Gustaaf NNP cord-010119-t1x9gknd 12554 12 de de NNP cord-010119-t1x9gknd 12554 13 Ridder Ridder NNP cord-010119-t1x9gknd 12554 14 * * NFP cord-010119-t1x9gknd 12554 15 1 1 CD cord-010119-t1x9gknd 12554 16 , , , cord-010119-t1x9gknd 12554 17 Rachel Rachel NNP cord-010119-t1x9gknd 12554 18 Jug Jug NNP cord-010119-t1x9gknd 12554 19 1 1 CD cord-010119-t1x9gknd 12554 20 , , , cord-010119-t1x9gknd 12554 21 Kimberly Kimberly NNP cord-010119-t1x9gknd 12554 22 Ingersoll Ingersoll NNP cord-010119-t1x9gknd 12554 23 1 1 CD cord-010119-t1x9gknd 12554 24 , , , cord-010119-t1x9gknd 12554 25 Nicholas Nicholas NNP cord-010119-t1x9gknd 12554 26 Bandarenko Bandarenko NNP cord-010119-t1x9gknd 12554 27 2 2 CD cord-010119-t1x9gknd 12554 28 , , , cord-010119-t1x9gknd 12554 29 Nicole Nicole NNP cord-010119-t1x9gknd 12554 30 Guinn Guinn NNP cord-010119-t1x9gknd 12554 31 3 3 CD cord-010119-t1x9gknd 12554 32 and and CC cord-010119-t1x9gknd 12554 33 Jessica Jessica NNP cord-010119-t1x9gknd 12554 34 Poisson Poisson NNP cord-010119-t1x9gknd 12555 1 2 2 LS cord-010119-t1x9gknd 12555 2 . . . cord-010119-t1x9gknd 12555 3 1 1 CD cord-010119-t1x9gknd 12555 4 Duke Duke NNP cord-010119-t1x9gknd 12555 5 Health Health NNP cord-010119-t1x9gknd 12555 6 Pathology Pathology NNP cord-010119-t1x9gknd 12555 7 , , , cord-010119-t1x9gknd 12555 8 2 2 CD cord-010119-t1x9gknd 12555 9 Duke Duke NNP cord-010119-t1x9gknd 12555 10 University University NNP cord-010119-t1x9gknd 12555 11 Hospital Hospital NNP cord-010119-t1x9gknd 12555 12 , , , cord-010119-t1x9gknd 12555 13 3 3 CD cord-010119-t1x9gknd 12555 14 Duke Duke NNP cord-010119-t1x9gknd 12555 15 Health Health NNP cord-010119-t1x9gknd 12555 16 Anesthesiology Anesthesiology NNP cord-010119-t1x9gknd 12555 17 Background Background NNP cord-010119-t1x9gknd 12555 18 / / SYM cord-010119-t1x9gknd 12555 19 Case Case NNP cord-010119-t1x9gknd 12555 20 Studies Studies NNPS cord-010119-t1x9gknd 12555 21 : : : cord-010119-t1x9gknd 12555 22 Hemorrhage hemorrhage NN cord-010119-t1x9gknd 12555 23 is be VBZ cord-010119-t1x9gknd 12555 24 both both CC cord-010119-t1x9gknd 12555 25 a a DT cord-010119-t1x9gknd 12555 26 leading leading JJ cord-010119-t1x9gknd 12555 27 cause cause NN cord-010119-t1x9gknd 12555 28 of of IN cord-010119-t1x9gknd 12555 29 mortality mortality NN cord-010119-t1x9gknd 12555 30 in in IN cord-010119-t1x9gknd 12555 31 trauma trauma NN cord-010119-t1x9gknd 12555 32 patients patient NNS cord-010119-t1x9gknd 12555 33 and and CC cord-010119-t1x9gknd 12555 34 morbidity morbidity NN cord-010119-t1x9gknd 12555 35 in in IN cord-010119-t1x9gknd 12555 36 non non JJ cord-010119-t1x9gknd 12555 37 - - JJ cord-010119-t1x9gknd 12555 38 trauma trauma JJ cord-010119-t1x9gknd 12555 39 patients patient NNS cord-010119-t1x9gknd 12555 40 . . . cord-010119-t1x9gknd 12556 1 Using use VBG cord-010119-t1x9gknd 12556 2 a a DT cord-010119-t1x9gknd 12556 3 balanced balanced JJ cord-010119-t1x9gknd 12556 4 6:6:1 6:6:1 CD cord-010119-t1x9gknd 12556 5 transfusion transfusion NN cord-010119-t1x9gknd 12556 6 ratio ratio NN cord-010119-t1x9gknd 12556 7 ( ( -LRB- cord-010119-t1x9gknd 12556 8 TR TR NNP cord-010119-t1x9gknd 12556 9 ) ) -RRB- cord-010119-t1x9gknd 12556 10 for for IN cord-010119-t1x9gknd 12556 11 massive massive JJ cord-010119-t1x9gknd 12556 12 resuscitation resuscitation NN cord-010119-t1x9gknd 12556 13 is be VBZ cord-010119-t1x9gknd 12556 14 recommended recommend VBN cord-010119-t1x9gknd 12556 15 based base VBN cord-010119-t1x9gknd 12556 16 on on IN cord-010119-t1x9gknd 12556 17 trauma trauma NN cord-010119-t1x9gknd 12556 18 data datum NNS cord-010119-t1x9gknd 12556 19 . . . cord-010119-t1x9gknd 12557 1 Objective objective JJ cord-010119-t1x9gknd 12557 2 performance performance NN cord-010119-t1x9gknd 12557 3 during during IN cord-010119-t1x9gknd 12557 4 Massive Massive NNP cord-010119-t1x9gknd 12557 5 Transfusion Transfusion NNP cord-010119-t1x9gknd 12557 6 Protocol Protocol NNP cord-010119-t1x9gknd 12557 7 ( ( -LRB- cord-010119-t1x9gknd 12557 8 MTP MTP NNP cord-010119-t1x9gknd 12557 9 ) ) -RRB- cord-010119-t1x9gknd 12557 10 activations activation NNS cord-010119-t1x9gknd 12557 11 is be VBZ cord-010119-t1x9gknd 12557 12 poorly poorly RB cord-010119-t1x9gknd 12557 13 studied study VBN cord-010119-t1x9gknd 12557 14 and and CC cord-010119-t1x9gknd 12557 15 there there EX cord-010119-t1x9gknd 12557 16 may may MD cord-010119-t1x9gknd 12557 17 be be VB cord-010119-t1x9gknd 12557 18 differences difference NNS cord-010119-t1x9gknd 12557 19 based base VBN cord-010119-t1x9gknd 12557 20 on on IN cord-010119-t1x9gknd 12557 21 site site NN cord-010119-t1x9gknd 12557 22 or or CC cord-010119-t1x9gknd 12557 23 medical medical JJ cord-010119-t1x9gknd 12557 24 service service NN cord-010119-t1x9gknd 12557 25 of of IN cord-010119-t1x9gknd 12557 26 MTP MTP NNP cord-010119-t1x9gknd 12557 27 initiation initiation NN cord-010119-t1x9gknd 12557 28 . . . cord-010119-t1x9gknd 12558 1 With with IN cord-010119-t1x9gknd 12558 2 the the DT cord-010119-t1x9gknd 12558 3 impending impending JJ cord-010119-t1x9gknd 12558 4 release release NN cord-010119-t1x9gknd 12558 5 of of IN cord-010119-t1x9gknd 12558 6 a a DT cord-010119-t1x9gknd 12558 7 unified unified JJ cord-010119-t1x9gknd 12558 8 , , , cord-010119-t1x9gknd 12558 9 redesigned redesign VBN cord-010119-t1x9gknd 12558 10 Exsanguination Exsanguination NNP cord-010119-t1x9gknd 12558 11 Protocol Protocol NNP cord-010119-t1x9gknd 12558 12 ( ( -LRB- cord-010119-t1x9gknd 12558 13 ExP exp NN cord-010119-t1x9gknd 12558 14 ) ) -RRB- cord-010119-t1x9gknd 12558 15 at at IN cord-010119-t1x9gknd 12558 16 our -PRON- PRP$ cord-010119-t1x9gknd 12558 17 institution institution NN cord-010119-t1x9gknd 12558 18 , , , cord-010119-t1x9gknd 12558 19 we -PRON- PRP cord-010119-t1x9gknd 12558 20 established establish VBD cord-010119-t1x9gknd 12558 21 baseline baseline JJ cord-010119-t1x9gknd 12558 22 performance performance NN cord-010119-t1x9gknd 12558 23 characteristics characteristic NNS cord-010119-t1x9gknd 12558 24 for for IN cord-010119-t1x9gknd 12558 25 our -PRON- PRP$ cord-010119-t1x9gknd 12558 26 existing exist VBG cord-010119-t1x9gknd 12558 27 MTP MTP NNP cord-010119-t1x9gknd 12558 28 and and CC cord-010119-t1x9gknd 12558 29 Obstetric Obstetric NNP cord-010119-t1x9gknd 12558 30 Massive Massive NNP cord-010119-t1x9gknd 12558 31 Transfusion Transfusion NNP cord-010119-t1x9gknd 12558 32 Protocol Protocol NNP cord-010119-t1x9gknd 12558 33 ( ( -LRB- cord-010119-t1x9gknd 12558 34 OBP OBP NNP cord-010119-t1x9gknd 12558 35 ) ) -RRB- cord-010119-t1x9gknd 12558 36 . . . cord-010119-t1x9gknd 12559 1 Study Study NNP cord-010119-t1x9gknd 12559 2 Design Design NNP cord-010119-t1x9gknd 12559 3 / / SYM cord-010119-t1x9gknd 12559 4 Method method NN cord-010119-t1x9gknd 12559 5 : : : cord-010119-t1x9gknd 12560 1 Following follow VBG cord-010119-t1x9gknd 12560 2 Institutional Institutional NNP cord-010119-t1x9gknd 12560 3 Review Review NNP cord-010119-t1x9gknd 12560 4 Board Board NNP cord-010119-t1x9gknd 12560 5 approval approval NN cord-010119-t1x9gknd 12560 6 , , , cord-010119-t1x9gknd 12560 7 we -PRON- PRP cord-010119-t1x9gknd 12560 8 performed perform VBD cord-010119-t1x9gknd 12560 9 a a DT cord-010119-t1x9gknd 12560 10 retrospective retrospective JJ cord-010119-t1x9gknd 12560 11 study study NN cord-010119-t1x9gknd 12560 12 on on IN cord-010119-t1x9gknd 12560 13 blood blood NN cord-010119-t1x9gknd 12560 14 product product NN cord-010119-t1x9gknd 12560 15 utilization utilization NN cord-010119-t1x9gknd 12560 16 and and CC cord-010119-t1x9gknd 12560 17 outcomes outcome NNS cord-010119-t1x9gknd 12560 18 of of IN cord-010119-t1x9gknd 12560 19 MTP MTP NNP cord-010119-t1x9gknd 12560 20 and and CC cord-010119-t1x9gknd 12560 21 OBP OBP NNP cord-010119-t1x9gknd 12560 22 activations activation NNS cord-010119-t1x9gknd 12560 23 from from IN cord-010119-t1x9gknd 12560 24 July July NNP cord-010119-t1x9gknd 12560 25 2015-December 2015-december CD cord-010119-t1x9gknd 12560 26 2016 2016 CD cord-010119-t1x9gknd 12560 27 . . . cord-010119-t1x9gknd 12561 1 Data datum NNS cord-010119-t1x9gknd 12561 2 were be VBD cord-010119-t1x9gknd 12561 3 manually manually RB cord-010119-t1x9gknd 12561 4 collected collect VBN cord-010119-t1x9gknd 12561 5 from from IN cord-010119-t1x9gknd 12561 6 transfusion transfusion NN cord-010119-t1x9gknd 12561 7 service service NN cord-010119-t1x9gknd 12561 8 paper paper NN cord-010119-t1x9gknd 12561 9 records record NNS cord-010119-t1x9gknd 12561 10 , , , cord-010119-t1x9gknd 12561 11 electronic electronic JJ cord-010119-t1x9gknd 12561 12 ( ( -LRB- cord-010119-t1x9gknd 12561 13 Safe Safe NNP cord-010119-t1x9gknd 12561 14 - - HYPH cord-010119-t1x9gknd 12561 15 Trace trace NN cord-010119-t1x9gknd 12561 16 ) ) -RRB- cord-010119-t1x9gknd 12561 17 records record NNS cord-010119-t1x9gknd 12561 18 , , , cord-010119-t1x9gknd 12561 19 and and CC cord-010119-t1x9gknd 12561 20 an an DT cord-010119-t1x9gknd 12561 21 automated automate VBN cord-010119-t1x9gknd 12561 22 data data NN cord-010119-t1x9gknd 12561 23 report report NN cord-010119-t1x9gknd 12561 24 from from IN cord-010119-t1x9gknd 12561 25 the the DT cord-010119-t1x9gknd 12561 26 electronic electronic JJ cord-010119-t1x9gknd 12561 27 medical medical JJ cord-010119-t1x9gknd 12561 28 record record NN cord-010119-t1x9gknd 12561 29 ( ( -LRB- cord-010119-t1x9gknd 12561 30 Epic Epic NNP cord-010119-t1x9gknd 12561 31 ) ) -RRB- cord-010119-t1x9gknd 12561 32 . . . cord-010119-t1x9gknd 12562 1 Conclusion conclusion NN cord-010119-t1x9gknd 12562 2 : : : cord-010119-t1x9gknd 12563 1 We -PRON- PRP cord-010119-t1x9gknd 12563 2 observed observe VBD cord-010119-t1x9gknd 12563 3 considerable considerable JJ cord-010119-t1x9gknd 12563 4 variability variability NN cord-010119-t1x9gknd 12563 5 in in IN cord-010119-t1x9gknd 12563 6 transfusion transfusion NN cord-010119-t1x9gknd 12563 7 practices practice NNS cord-010119-t1x9gknd 12563 8 during during IN cord-010119-t1x9gknd 12563 9 acute acute JJ cord-010119-t1x9gknd 12563 10 hemorrhage hemorrhage NN cord-010119-t1x9gknd 12563 11 depending depend VBG cord-010119-t1x9gknd 12563 12 on on IN cord-010119-t1x9gknd 12563 13 the the DT cord-010119-t1x9gknd 12563 14 service service NN cord-010119-t1x9gknd 12563 15 and and CC cord-010119-t1x9gknd 12563 16 location location NN cord-010119-t1x9gknd 12563 17 of of IN cord-010119-t1x9gknd 12563 18 activation activation NN cord-010119-t1x9gknd 12563 19 . . . cord-010119-t1x9gknd 12564 1 Trauma trauma NN cord-010119-t1x9gknd 12564 2 activations activation NNS cord-010119-t1x9gknd 12564 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 12564 4 the the DT cord-010119-t1x9gknd 12564 5 sharpest sharp JJS cord-010119-t1x9gknd 12564 6 deficit deficit NN cord-010119-t1x9gknd 12564 7 in in IN cord-010119-t1x9gknd 12564 8 platelet platelet NN cord-010119-t1x9gknd 12564 9 transfusion transfusion NN cord-010119-t1x9gknd 12564 10 , , , cord-010119-t1x9gknd 12564 11 whereas whereas IN cord-010119-t1x9gknd 12564 12 all all DT cord-010119-t1x9gknd 12564 13 groups group NNS cord-010119-t1x9gknd 12564 14 lagged lag VBD cord-010119-t1x9gknd 12564 15 somewhat somewhat RB cord-010119-t1x9gknd 12564 16 in in IN cord-010119-t1x9gknd 12564 17 transfused transfuse VBN cord-010119-t1x9gknd 12564 18 plasma plasma NN cord-010119-t1x9gknd 12564 19 relative relative JJ cord-010119-t1x9gknd 12564 20 to to IN cord-010119-t1x9gknd 12564 21 packed packed JJ cord-010119-t1x9gknd 12564 22 red red JJ cord-010119-t1x9gknd 12564 23 blood blood NN cord-010119-t1x9gknd 12564 24 cells cell NNS cord-010119-t1x9gknd 12564 25 . . . cord-010119-t1x9gknd 12565 1 LOS LOS NNP cord-010119-t1x9gknd 12565 2 and and CC cord-010119-t1x9gknd 12565 3 mortality mortality NN cord-010119-t1x9gknd 12565 4 varied varied JJ cord-010119-t1x9gknd 12565 5 among among IN cord-010119-t1x9gknd 12565 6 groups group NNS cord-010119-t1x9gknd 12565 7 , , , cord-010119-t1x9gknd 12565 8 likely likely RB cord-010119-t1x9gknd 12565 9 reflecting reflect VBG cord-010119-t1x9gknd 12565 10 underlying underlie VBG cord-010119-t1x9gknd 12565 11 medical medical JJ cord-010119-t1x9gknd 12565 12 conditions condition NNS cord-010119-t1x9gknd 12565 13 and and CC cord-010119-t1x9gknd 12565 14 indications indication NNS cord-010119-t1x9gknd 12565 15 for for IN cord-010119-t1x9gknd 12565 16 massive massive JJ cord-010119-t1x9gknd 12565 17 transfusion transfusion NN cord-010119-t1x9gknd 12565 18 . . . cord-010119-t1x9gknd 12566 1 We -PRON- PRP cord-010119-t1x9gknd 12566 2 have have VBP cord-010119-t1x9gknd 12566 3 identified identify VBN cord-010119-t1x9gknd 12566 4 an an DT cord-010119-t1x9gknd 12566 5 opportunity opportunity NN cord-010119-t1x9gknd 12566 6 for for IN cord-010119-t1x9gknd 12566 7 improvement improvement NN cord-010119-t1x9gknd 12566 8 in in IN cord-010119-t1x9gknd 12566 9 MTP MTP NNP cord-010119-t1x9gknd 12566 10 transfusion transfusion NN cord-010119-t1x9gknd 12566 11 ratios ratio NNS cord-010119-t1x9gknd 12566 12 observed observe VBN cord-010119-t1x9gknd 12566 13 in in IN cord-010119-t1x9gknd 12566 14 trauma trauma NN cord-010119-t1x9gknd 12566 15 cases case NNS cord-010119-t1x9gknd 12566 16 , , , cord-010119-t1x9gknd 12566 17 the the DT cord-010119-t1x9gknd 12566 18 specific specific JJ cord-010119-t1x9gknd 12566 19 environment environment NN cord-010119-t1x9gknd 12566 20 from from IN cord-010119-t1x9gknd 12566 21 which which WDT cord-010119-t1x9gknd 12566 22 the the DT cord-010119-t1x9gknd 12566 23 6:6:1 6:6:1 CD cord-010119-t1x9gknd 12566 24 ratio ratio NN cord-010119-t1x9gknd 12566 25 was be VBD cord-010119-t1x9gknd 12566 26 derived derive VBN cord-010119-t1x9gknd 12566 27 , , , cord-010119-t1x9gknd 12566 28 and and CC cord-010119-t1x9gknd 12566 29 in in IN cord-010119-t1x9gknd 12566 30 which which WDT cord-010119-t1x9gknd 12566 31 the the DT cord-010119-t1x9gknd 12566 32 impact impact NN cord-010119-t1x9gknd 12566 33 of of IN cord-010119-t1x9gknd 12566 34 protocol protocol NN cord-010119-t1x9gknd 12566 35 - - HYPH cord-010119-t1x9gknd 12566 36 driven drive VBN cord-010119-t1x9gknd 12566 37 blood blood NN cord-010119-t1x9gknd 12566 38 resuscitation resuscitation NN cord-010119-t1x9gknd 12566 39 is be VBZ cord-010119-t1x9gknd 12566 40 most most RBS cord-010119-t1x9gknd 12566 41 efficacious efficacious JJ cord-010119-t1x9gknd 12566 42 . . . cord-010119-t1x9gknd 12567 1 Patient Patient NNP cord-010119-t1x9gknd 12567 2 Identification identification NN cord-010119-t1x9gknd 12567 3 Improvement Improvement NNP cord-010119-t1x9gknd 12567 4 Strategy Strategy NNP cord-010119-t1x9gknd 12567 5 to to TO cord-010119-t1x9gknd 12567 6 Help help VB cord-010119-t1x9gknd 12567 7 Reduce reduce VB cord-010119-t1x9gknd 12567 8 Unacceptable unacceptable JJ cord-010119-t1x9gknd 12567 9 Specimens Specimens NNP cord-010119-t1x9gknd 12567 10 Arline Arline NNP cord-010119-t1x9gknd 12567 11 Stein Stein NNP cord-010119-t1x9gknd 12567 12 * * NFP cord-010119-t1x9gknd 12567 13 1 1 CD cord-010119-t1x9gknd 12567 14 , , , cord-010119-t1x9gknd 12567 15 Nancy Nancy NNP cord-010119-t1x9gknd 12567 16 Nikolis Nikolis NNP cord-010119-t1x9gknd 12567 17 1 1 CD cord-010119-t1x9gknd 12567 18 , , , cord-010119-t1x9gknd 12567 19 Linda Linda NNP cord-010119-t1x9gknd 12567 20 Benison Benison NNP cord-010119-t1x9gknd 12567 21 1 1 CD cord-010119-t1x9gknd 12567 22 , , , cord-010119-t1x9gknd 12567 23 Ruthmire Ruthmire NNP cord-010119-t1x9gknd 12567 24 Thelusca Thelusca NNP cord-010119-t1x9gknd 12567 25 1 1 CD cord-010119-t1x9gknd 12567 26 , , , cord-010119-t1x9gknd 12567 27 Renee Renee NNP cord-010119-t1x9gknd 12567 28 Liberty Liberty NNP cord-010119-t1x9gknd 12567 29 1 1 CD cord-010119-t1x9gknd 12567 30 , , , cord-010119-t1x9gknd 12567 31 Sherry Sherry NNP cord-010119-t1x9gknd 12567 32 Shariatmadar Shariatmadar NNP cord-010119-t1x9gknd 12567 33 1 1 CD cord-010119-t1x9gknd 12567 34 , , , cord-010119-t1x9gknd 12567 35 Alexander Alexander NNP cord-010119-t1x9gknd 12567 36 Indrikovs Indrikovs NNP cord-010119-t1x9gknd 12567 37 2 2 CD cord-010119-t1x9gknd 12567 38 and and CC cord-010119-t1x9gknd 12567 39 Vishesh Vishesh NNP cord-010119-t1x9gknd 12567 40 Chhibber Chhibber NNP cord-010119-t1x9gknd 12567 41 1 1 CD cord-010119-t1x9gknd 12567 42 . . . cord-010119-t1x9gknd 12567 43 1 1 CD cord-010119-t1x9gknd 12567 44 North North NNP cord-010119-t1x9gknd 12567 45 Shore Shore NNP cord-010119-t1x9gknd 12567 46 University University NNP cord-010119-t1x9gknd 12567 47 Hospital Hospital NNP cord-010119-t1x9gknd 12567 48 , , , cord-010119-t1x9gknd 12567 49 2 2 CD cord-010119-t1x9gknd 12567 50 Northwell Northwell NNP cord-010119-t1x9gknd 12567 51 Health Health NNP cord-010119-t1x9gknd 12567 52 Background Background NNP cord-010119-t1x9gknd 12567 53 / / SYM cord-010119-t1x9gknd 12567 54 Case Case NNP cord-010119-t1x9gknd 12567 55 Studies Studies NNPS cord-010119-t1x9gknd 12567 56 : : : cord-010119-t1x9gknd 12567 57 Our -PRON- PRP$ cord-010119-t1x9gknd 12567 58 blood blood NN cord-010119-t1x9gknd 12567 59 bank bank NN cord-010119-t1x9gknd 12567 60 ( ( -LRB- cord-010119-t1x9gknd 12567 61 BB BB NNP cord-010119-t1x9gknd 12567 62 ) ) -RRB- cord-010119-t1x9gknd 12567 63 processes process VBZ cord-010119-t1x9gknd 12567 64 approximately approximately RB cord-010119-t1x9gknd 12567 65 60,000 60,000 CD cord-010119-t1x9gknd 12567 66 specimens specimen NNS cord-010119-t1x9gknd 12567 67 per per IN cord-010119-t1x9gknd 12567 68 year year NN cord-010119-t1x9gknd 12567 69 . . . cord-010119-t1x9gknd 12568 1 BB bb NN cord-010119-t1x9gknd 12568 2 specimens specimen NNS cord-010119-t1x9gknd 12568 3 are be VBP cord-010119-t1x9gknd 12568 4 unacceptable unacceptable JJ cord-010119-t1x9gknd 12568 5 when when WRB cord-010119-t1x9gknd 12568 6 they -PRON- PRP cord-010119-t1x9gknd 12568 7 are be VBP cord-010119-t1x9gknd 12568 8 unlabeled unlabeled JJ cord-010119-t1x9gknd 12568 9 , , , cord-010119-t1x9gknd 12568 10 unsigned unsigned JJ cord-010119-t1x9gknd 12568 11 or or CC cord-010119-t1x9gknd 12568 12 missing miss VBG cord-010119-t1x9gknd 12568 13 necessary necessary JJ cord-010119-t1x9gknd 12568 14 documentation documentation NN cord-010119-t1x9gknd 12568 15 . . . cord-010119-t1x9gknd 12569 1 In in IN cord-010119-t1x9gknd 12569 2 such such JJ cord-010119-t1x9gknd 12569 3 cases case NNS cord-010119-t1x9gknd 12569 4 , , , cord-010119-t1x9gknd 12569 5 a a DT cord-010119-t1x9gknd 12569 6 new new JJ cord-010119-t1x9gknd 12569 7 specimen specimen NN cord-010119-t1x9gknd 12569 8 is be VBZ cord-010119-t1x9gknd 12569 9 requested request VBN cord-010119-t1x9gknd 12569 10 to to TO cord-010119-t1x9gknd 12569 11 be be VB cord-010119-t1x9gknd 12569 12 drawn draw VBN cord-010119-t1x9gknd 12569 13 as as IN cord-010119-t1x9gknd 12569 14 per per IN cord-010119-t1x9gknd 12569 15 protocol protocol NN cord-010119-t1x9gknd 12569 16 . . . cord-010119-t1x9gknd 12570 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12570 2 investigation investigation NN cord-010119-t1x9gknd 12570 3 of of IN cord-010119-t1x9gknd 12570 4 unacceptable unacceptable JJ cord-010119-t1x9gknd 12570 5 specimens specimen NNS cord-010119-t1x9gknd 12570 6 previously previously RB cord-010119-t1x9gknd 12570 7 included include VBD cord-010119-t1x9gknd 12570 8 generation generation NN cord-010119-t1x9gknd 12570 9 of of IN cord-010119-t1x9gknd 12570 10 a a DT cord-010119-t1x9gknd 12570 11 report report NN cord-010119-t1x9gknd 12570 12 by by IN cord-010119-t1x9gknd 12570 13 the the DT cord-010119-t1x9gknd 12570 14 blood blood NN cord-010119-t1x9gknd 12570 15 bank bank NN cord-010119-t1x9gknd 12570 16 staff staff NN cord-010119-t1x9gknd 12570 17 that that WDT cord-010119-t1x9gknd 12570 18 was be VBD cord-010119-t1x9gknd 12570 19 subsequently subsequently RB cord-010119-t1x9gknd 12570 20 submitted submit VBN cord-010119-t1x9gknd 12570 21 to to IN cord-010119-t1x9gknd 12570 22 the the DT cord-010119-t1x9gknd 12570 23 BB BB NNP cord-010119-t1x9gknd 12570 24 supervisor supervisor NN cord-010119-t1x9gknd 12570 25 for for IN cord-010119-t1x9gknd 12570 26 completion completion NN cord-010119-t1x9gknd 12570 27 . . . cord-010119-t1x9gknd 12571 1 Following follow VBG cord-010119-t1x9gknd 12571 2 completion completion NN cord-010119-t1x9gknd 12571 3 , , , cord-010119-t1x9gknd 12571 4 the the DT cord-010119-t1x9gknd 12571 5 report report NN cord-010119-t1x9gknd 12571 6 was be VBD cord-010119-t1x9gknd 12571 7 sent send VBN cord-010119-t1x9gknd 12571 8 to to IN cord-010119-t1x9gknd 12571 9 the the DT cord-010119-t1x9gknd 12571 10 Nurse Nurse NNP cord-010119-t1x9gknd 12571 11 Manager Manager NNP cord-010119-t1x9gknd 12571 12 of of IN cord-010119-t1x9gknd 12571 13 the the DT cord-010119-t1x9gknd 12571 14 patient patient NN cord-010119-t1x9gknd 12571 15 care care NN cord-010119-t1x9gknd 12571 16 unit unit NN cord-010119-t1x9gknd 12571 17 ( ( -LRB- cord-010119-t1x9gknd 12571 18 PCU PCU NNP cord-010119-t1x9gknd 12571 19 ) ) -RRB- cord-010119-t1x9gknd 12571 20 for for IN cord-010119-t1x9gknd 12571 21 follow follow NN cord-010119-t1x9gknd 12571 22 - - HYPH cord-010119-t1x9gknd 12571 23 up up NN cord-010119-t1x9gknd 12571 24 and and CC cord-010119-t1x9gknd 12571 25 investigation investigation NN cord-010119-t1x9gknd 12571 26 with with IN cord-010119-t1x9gknd 12571 27 the the DT cord-010119-t1x9gknd 12571 28 staff staff NN cord-010119-t1x9gknd 12571 29 members member NNS cord-010119-t1x9gknd 12571 30 involved involve VBN cord-010119-t1x9gknd 12571 31 . . . cord-010119-t1x9gknd 12572 1 This this DT cord-010119-t1x9gknd 12572 2 process process NN cord-010119-t1x9gknd 12572 3 was be VBD cord-010119-t1x9gknd 12572 4 cumbersome cumbersome JJ cord-010119-t1x9gknd 12572 5 , , , cord-010119-t1x9gknd 12572 6 taking take VBG cord-010119-t1x9gknd 12572 7 a a DT cord-010119-t1x9gknd 12572 8 few few JJ cord-010119-t1x9gknd 12572 9 days day NNS cord-010119-t1x9gknd 12572 10 before before IN cord-010119-t1x9gknd 12572 11 the the DT cord-010119-t1x9gknd 12572 12 staff staff NN cord-010119-t1x9gknd 12572 13 member member NN cord-010119-t1x9gknd 12572 14 of of IN cord-010119-t1x9gknd 12572 15 the the DT cord-010119-t1x9gknd 12572 16 PCU PCU NNP cord-010119-t1x9gknd 12572 17 was be VBD cord-010119-t1x9gknd 12572 18 alerted alert VBN cord-010119-t1x9gknd 12572 19 to to IN cord-010119-t1x9gknd 12572 20 the the DT cord-010119-t1x9gknd 12572 21 deviation deviation NN cord-010119-t1x9gknd 12572 22 in in IN cord-010119-t1x9gknd 12572 23 protocol protocol NN cord-010119-t1x9gknd 12572 24 . . . cord-010119-t1x9gknd 12573 1 At at IN cord-010119-t1x9gknd 12573 2 times time NNS cord-010119-t1x9gknd 12573 3 , , , cord-010119-t1x9gknd 12573 4 residents resident NNS cord-010119-t1x9gknd 12573 5 or or CC cord-010119-t1x9gknd 12573 6 float float VB cord-010119-t1x9gknd 12573 7 staff staff NN cord-010119-t1x9gknd 12573 8 involved involve VBN cord-010119-t1x9gknd 12573 9 were be VBD cord-010119-t1x9gknd 12573 10 difficult difficult JJ cord-010119-t1x9gknd 12573 11 to to TO cord-010119-t1x9gknd 12573 12 identify identify VB cord-010119-t1x9gknd 12573 13 and and CC cord-010119-t1x9gknd 12573 14 it -PRON- PRP cord-010119-t1x9gknd 12573 15 was be VBD cord-010119-t1x9gknd 12573 16 often often RB cord-010119-t1x9gknd 12573 17 challenging challenge VBG cord-010119-t1x9gknd 12573 18 to to TO cord-010119-t1x9gknd 12573 19 track track VB cord-010119-t1x9gknd 12573 20 down down RP cord-010119-t1x9gknd 12573 21 the the DT cord-010119-t1x9gknd 12573 22 staff staff NN cord-010119-t1x9gknd 12573 23 and and CC cord-010119-t1x9gknd 12573 24 do do VB cord-010119-t1x9gknd 12573 25 the the DT cord-010119-t1x9gknd 12573 26 necessary necessary JJ cord-010119-t1x9gknd 12573 27 investigations investigation NNS cord-010119-t1x9gknd 12573 28 and and CC cord-010119-t1x9gknd 12573 29 in in IN cord-010119-t1x9gknd 12573 30 - - HYPH cord-010119-t1x9gknd 12573 31 services service NNS cord-010119-t1x9gknd 12573 32 . . . cord-010119-t1x9gknd 12574 1 Study Study NNP cord-010119-t1x9gknd 12574 2 Design Design NNP cord-010119-t1x9gknd 12574 3 / / SYM cord-010119-t1x9gknd 12574 4 Method method NN cord-010119-t1x9gknd 12574 5 : : : cord-010119-t1x9gknd 12575 1 In in IN cord-010119-t1x9gknd 12575 2 June June NNP cord-010119-t1x9gknd 12575 3 2016 2016 CD cord-010119-t1x9gknd 12575 4 , , , cord-010119-t1x9gknd 12575 5 a a DT cord-010119-t1x9gknd 12575 6 Patient Patient NNP cord-010119-t1x9gknd 12575 7 Identification Identification NNP cord-010119-t1x9gknd 12575 8 Improvement Improvement NNP cord-010119-t1x9gknd 12575 9 Strategy Strategy NNP cord-010119-t1x9gknd 12575 10 was be VBD cord-010119-t1x9gknd 12575 11 implemented implement VBN cord-010119-t1x9gknd 12575 12 jointly jointly RB cord-010119-t1x9gknd 12575 13 by by IN cord-010119-t1x9gknd 12575 14 the the DT cord-010119-t1x9gknd 12575 15 department department NNP cord-010119-t1x9gknd 12575 16 of of IN cord-010119-t1x9gknd 12575 17 nursing nursing NN cord-010119-t1x9gknd 12575 18 and and CC cord-010119-t1x9gknd 12575 19 the the DT cord-010119-t1x9gknd 12575 20 BB BB NNP cord-010119-t1x9gknd 12575 21 to to TO cord-010119-t1x9gknd 12575 22 address address VB cord-010119-t1x9gknd 12575 23 mislabeled mislabele VBN cord-010119-t1x9gknd 12575 24 , , , cord-010119-t1x9gknd 12575 25 unlabeled unlabeled JJ cord-010119-t1x9gknd 12575 26 and and CC cord-010119-t1x9gknd 12575 27 unsigned unsigned JJ cord-010119-t1x9gknd 12575 28 specimens specimen NNS cord-010119-t1x9gknd 12575 29 as as IN cord-010119-t1x9gknd 12575 30 part part NN cord-010119-t1x9gknd 12575 31 of of IN cord-010119-t1x9gknd 12575 32 a a DT cord-010119-t1x9gknd 12575 33 Patient Patient NNP cord-010119-t1x9gknd 12575 34 Safety Safety NNP cord-010119-t1x9gknd 12575 35 Initiative Initiative NNP cord-010119-t1x9gknd 12575 36 . . . cord-010119-t1x9gknd 12576 1 Currently currently RB cord-010119-t1x9gknd 12576 2 , , , cord-010119-t1x9gknd 12576 3 following follow VBG cord-010119-t1x9gknd 12576 4 this this DT cord-010119-t1x9gknd 12576 5 strategy strategy NN cord-010119-t1x9gknd 12576 6 , , , cord-010119-t1x9gknd 12576 7 when when WRB cord-010119-t1x9gknd 12576 8 an an DT cord-010119-t1x9gknd 12576 9 unacceptable unacceptable JJ cord-010119-t1x9gknd 12576 10 specimen specimen NN cord-010119-t1x9gknd 12576 11 is be VBZ cord-010119-t1x9gknd 12576 12 received receive VBN cord-010119-t1x9gknd 12576 13 , , , cord-010119-t1x9gknd 12576 14 the the DT cord-010119-t1x9gknd 12576 15 Nurse Nurse NNP cord-010119-t1x9gknd 12576 16 Manager Manager NNP cord-010119-t1x9gknd 12576 17 ( ( -LRB- cord-010119-t1x9gknd 12576 18 NM NM NNP cord-010119-t1x9gknd 12576 19 ) ) -RRB- cord-010119-t1x9gknd 12576 20 of of IN cord-010119-t1x9gknd 12576 21 the the DT cord-010119-t1x9gknd 12576 22 PCU PCU NNP cord-010119-t1x9gknd 12576 23 is be VBZ cord-010119-t1x9gknd 12576 24 immediately immediately RB cord-010119-t1x9gknd 12576 25 notified notify VBN cord-010119-t1x9gknd 12576 26 by by IN cord-010119-t1x9gknd 12576 27 BB BB NNP cord-010119-t1x9gknd 12576 28 Staff Staff NNP cord-010119-t1x9gknd 12576 29 . . . cord-010119-t1x9gknd 12577 1 The the DT cord-010119-t1x9gknd 12577 2 NM NM NNP cord-010119-t1x9gknd 12577 3 promptly promptly RB cord-010119-t1x9gknd 12577 4 initiates initiate VBZ cord-010119-t1x9gknd 12577 5 a a DT cord-010119-t1x9gknd 12577 6 debrief debrief NN cord-010119-t1x9gknd 12577 7 process process NN cord-010119-t1x9gknd 12577 8 with with IN cord-010119-t1x9gknd 12577 9 the the DT cord-010119-t1x9gknd 12577 10 staff staff NN cord-010119-t1x9gknd 12577 11 involved involve VBN cord-010119-t1x9gknd 12577 12 in in IN cord-010119-t1x9gknd 12577 13 drawing draw VBG cord-010119-t1x9gknd 12577 14 the the DT cord-010119-t1x9gknd 12577 15 specimen specimen NN cord-010119-t1x9gknd 12577 16 . . . cord-010119-t1x9gknd 12578 1 A a DT cord-010119-t1x9gknd 12578 2 debrief debrief NN cord-010119-t1x9gknd 12578 3 form form NN cord-010119-t1x9gknd 12578 4 ( ( -LRB- cord-010119-t1x9gknd 12578 5 tool tool NN cord-010119-t1x9gknd 12578 6 ) ) -RRB- cord-010119-t1x9gknd 12578 7 was be VBD cord-010119-t1x9gknd 12578 8 created create VBN cord-010119-t1x9gknd 12578 9 to to TO cord-010119-t1x9gknd 12578 10 guide guide VB cord-010119-t1x9gknd 12578 11 the the DT cord-010119-t1x9gknd 12578 12 discussion discussion NN cord-010119-t1x9gknd 12578 13 . . . cord-010119-t1x9gknd 12579 1 This this DT cord-010119-t1x9gknd 12579 2 process process NN cord-010119-t1x9gknd 12579 3 is be VBZ cord-010119-t1x9gknd 12579 4 followed follow VBN cord-010119-t1x9gknd 12579 5 24/7 24/7 RB cord-010119-t1x9gknd 12579 6 . . . cord-010119-t1x9gknd 12580 1 The the DT cord-010119-t1x9gknd 12580 2 NM NM NNP cord-010119-t1x9gknd 12580 3 will will MD cord-010119-t1x9gknd 12580 4 also also RB cord-010119-t1x9gknd 12580 5 engage engage VB cord-010119-t1x9gknd 12580 6 other other JJ cord-010119-t1x9gknd 12580 7 available available JJ cord-010119-t1x9gknd 12580 8 staff staff NN cord-010119-t1x9gknd 12580 9 in in IN cord-010119-t1x9gknd 12580 10 a a DT cord-010119-t1x9gknd 12580 11 huddle huddle NN cord-010119-t1x9gknd 12580 12 to to TO cord-010119-t1x9gknd 12580 13 review review VB cord-010119-t1x9gknd 12580 14 the the DT cord-010119-t1x9gknd 12580 15 incident incident NN cord-010119-t1x9gknd 12580 16 and and CC cord-010119-t1x9gknd 12580 17 reinforce reinforce VB cord-010119-t1x9gknd 12580 18 the the DT cord-010119-t1x9gknd 12580 19 policy policy NN cord-010119-t1x9gknd 12580 20 . . . cord-010119-t1x9gknd 12581 1 The the DT cord-010119-t1x9gknd 12581 2 debrief debrief NN cord-010119-t1x9gknd 12581 3 form form NN cord-010119-t1x9gknd 12581 4 is be VBZ cord-010119-t1x9gknd 12581 5 then then RB cord-010119-t1x9gknd 12581 6 submitted submit VBN cord-010119-t1x9gknd 12581 7 to to IN cord-010119-t1x9gknd 12581 8 hospital hospital NN cord-010119-t1x9gknd 12581 9 QA QA NNP cord-010119-t1x9gknd 12581 10 and and CC cord-010119-t1x9gknd 12581 11 the the DT cord-010119-t1x9gknd 12581 12 BB bb NN cord-010119-t1x9gknd 12581 13 with with IN cord-010119-t1x9gknd 12581 14 preventative preventative JJ cord-010119-t1x9gknd 12581 15 actions action NNS cord-010119-t1x9gknd 12581 16 included include VBN cord-010119-t1x9gknd 12581 17 . . . cord-010119-t1x9gknd 12582 1 We -PRON- PRP cord-010119-t1x9gknd 12582 2 believe believe VBP cord-010119-t1x9gknd 12582 3 in in IN cord-010119-t1x9gknd 12582 4 using use VBG cord-010119-t1x9gknd 12582 5 the the DT cord-010119-t1x9gknd 12582 6 JUST JUST NNP cord-010119-t1x9gknd 12582 7 CULTURE culture NN cord-010119-t1x9gknd 12582 8 MODEL model NN cord-010119-t1x9gknd 12582 9 to to TO cord-010119-t1x9gknd 12582 10 help help VB cord-010119-t1x9gknd 12582 11 us -PRON- PRP cord-010119-t1x9gknd 12582 12 understand understand VB cord-010119-t1x9gknd 12582 13 the the DT cord-010119-t1x9gknd 12582 14 reasons reason NNS cord-010119-t1x9gknd 12582 15 why why WRB cord-010119-t1x9gknd 12582 16 the the DT cord-010119-t1x9gknd 12582 17 staff staff NN cord-010119-t1x9gknd 12582 18 did do VBD cord-010119-t1x9gknd 12582 19 not not RB cord-010119-t1x9gknd 12582 20 label label VB cord-010119-t1x9gknd 12582 21 the the DT cord-010119-t1x9gknd 12582 22 specimen specimen NN cord-010119-t1x9gknd 12582 23 according accord VBG cord-010119-t1x9gknd 12582 24 to to IN cord-010119-t1x9gknd 12582 25 policy policy NN cord-010119-t1x9gknd 12582 26 . . . cord-010119-t1x9gknd 12583 1 Just just RB cord-010119-t1x9gknd 12583 2 culture culture NN cord-010119-t1x9gknd 12583 3 helps help VBZ cord-010119-t1x9gknd 12583 4 promote promote VB cord-010119-t1x9gknd 12583 5 shared share VBN cord-010119-t1x9gknd 12583 6 accountability accountability NN cord-010119-t1x9gknd 12583 7 to to TO cord-010119-t1x9gknd 12583 8 ensure ensure VB cord-010119-t1x9gknd 12583 9 we -PRON- PRP cord-010119-t1x9gknd 12583 10 have have VBP cord-010119-t1x9gknd 12583 11 the the DT cord-010119-t1x9gknd 12583 12 proper proper JJ cord-010119-t1x9gknd 12583 13 systems system NNS cord-010119-t1x9gknd 12583 14 and and CC cord-010119-t1x9gknd 12583 15 processes process NNS cord-010119-t1x9gknd 12583 16 in in IN cord-010119-t1x9gknd 12583 17 place place NN cord-010119-t1x9gknd 12583 18 to to TO cord-010119-t1x9gknd 12583 19 deliver deliver VB cord-010119-t1x9gknd 12583 20 high high JJ cord-010119-t1x9gknd 12583 21 quality quality NN cord-010119-t1x9gknd 12583 22 care care NN cord-010119-t1x9gknd 12583 23 . . . cord-010119-t1x9gknd 12584 1 Results/ Results/ . cord-010119-t1x9gknd 12585 1 Finding finding NN cord-010119-t1x9gknd 12585 2 : : : cord-010119-t1x9gknd 12586 1 The the DT cord-010119-t1x9gknd 12586 2 table table NN cord-010119-t1x9gknd 12586 3 below below RB cord-010119-t1x9gknd 12586 4 represents represent VBZ cord-010119-t1x9gknd 12586 5 the the DT cord-010119-t1x9gknd 12586 6 percentage percentage NN cord-010119-t1x9gknd 12586 7 of of IN cord-010119-t1x9gknd 12586 8 unacceptable unacceptable JJ cord-010119-t1x9gknd 12586 9 specimens specimen NNS cord-010119-t1x9gknd 12586 10 identified identify VBN cord-010119-t1x9gknd 12586 11 by by IN cord-010119-t1x9gknd 12586 12 the the DT cord-010119-t1x9gknd 12586 13 BB bb NN cord-010119-t1x9gknd 12586 14 since since IN cord-010119-t1x9gknd 12586 15 the the DT cord-010119-t1x9gknd 12586 16 second second JJ cord-010119-t1x9gknd 12586 17 quarter quarter NN cord-010119-t1x9gknd 12586 18 of of IN cord-010119-t1x9gknd 12586 19 2016 2016 CD cord-010119-t1x9gknd 12586 20 . . . cord-010119-t1x9gknd 12587 1 The the DT cord-010119-t1x9gknd 12587 2 implementation implementation NN cord-010119-t1x9gknd 12587 3 of of IN cord-010119-t1x9gknd 12587 4 this this DT cord-010119-t1x9gknd 12587 5 new new JJ cord-010119-t1x9gknd 12587 6 process process NN cord-010119-t1x9gknd 12587 7 has have VBZ cord-010119-t1x9gknd 12587 8 led lead VBN cord-010119-t1x9gknd 12587 9 to to IN cord-010119-t1x9gknd 12587 10 a a DT cord-010119-t1x9gknd 12587 11 decrease decrease NN cord-010119-t1x9gknd 12587 12 in in IN cord-010119-t1x9gknd 12587 13 the the DT cord-010119-t1x9gknd 12587 14 number number NN cord-010119-t1x9gknd 12587 15 of of IN cord-010119-t1x9gknd 12587 16 unacceptable unacceptable JJ cord-010119-t1x9gknd 12587 17 specimens specimen NNS cord-010119-t1x9gknd 12587 18 up up IN cord-010119-t1x9gknd 12587 19 to to TO cord-010119-t1x9gknd 12587 20 30 30 CD cord-010119-t1x9gknd 12587 21 % % NN cord-010119-t1x9gknd 12587 22 quarterly quarterly RB cord-010119-t1x9gknd 12587 23 following follow VBG cord-010119-t1x9gknd 12587 24 its -PRON- PRP$ cord-010119-t1x9gknd 12587 25 implementation implementation NN cord-010119-t1x9gknd 12587 26 . . . cord-010119-t1x9gknd 12588 1 The the DT cord-010119-t1x9gknd 12588 2 opportunity opportunity NN cord-010119-t1x9gknd 12588 3 for for IN cord-010119-t1x9gknd 12588 4 direct direct JJ cord-010119-t1x9gknd 12588 5 intervention intervention NN cord-010119-t1x9gknd 12588 6 by by IN cord-010119-t1x9gknd 12588 7 the the DT cord-010119-t1x9gknd 12588 8 NM NM NNP cord-010119-t1x9gknd 12588 9 with with IN cord-010119-t1x9gknd 12588 10 the the DT cord-010119-t1x9gknd 12588 11 staff staff NN cord-010119-t1x9gknd 12588 12 involved involve VBN cord-010119-t1x9gknd 12588 13 has have VBZ cord-010119-t1x9gknd 12588 14 risen rise VBN cord-010119-t1x9gknd 12588 15 from from IN cord-010119-t1x9gknd 12588 16 75 75 CD cord-010119-t1x9gknd 12588 17 % % NN cord-010119-t1x9gknd 12588 18 to to IN cord-010119-t1x9gknd 12588 19 96 96 CD cord-010119-t1x9gknd 12588 20 % % NN cord-010119-t1x9gknd 12588 21 , , , cord-010119-t1x9gknd 12588 22 due due IN cord-010119-t1x9gknd 12588 23 to to IN cord-010119-t1x9gknd 12588 24 the the DT cord-010119-t1x9gknd 12588 25 immediate immediate JJ cord-010119-t1x9gknd 12588 26 debrief debrief NN cord-010119-t1x9gknd 12588 27 process process NN cord-010119-t1x9gknd 12588 28 . . . cord-010119-t1x9gknd 12589 1 ABSTRACT ABSTRACT NNP cord-010119-t1x9gknd 12589 2 Conclusion Conclusion NNP cord-010119-t1x9gknd 12589 3 : : : cord-010119-t1x9gknd 12589 4 The the DT cord-010119-t1x9gknd 12589 5 Patient Patient NNP cord-010119-t1x9gknd 12589 6 Identification Identification NNP cord-010119-t1x9gknd 12589 7 Improvement Improvement NNP cord-010119-t1x9gknd 12589 8 Strategy Strategy NNP cord-010119-t1x9gknd 12589 9 allows allow VBZ cord-010119-t1x9gknd 12589 10 for for IN cord-010119-t1x9gknd 12589 11 real real JJ cord-010119-t1x9gknd 12589 12 time time NN cord-010119-t1x9gknd 12589 13 engagement engagement NN cord-010119-t1x9gknd 12589 14 of of IN cord-010119-t1x9gknd 12589 15 the the DT cord-010119-t1x9gknd 12589 16 BB BB NNP cord-010119-t1x9gknd 12589 17 and and CC cord-010119-t1x9gknd 12589 18 PCU PCU NNP cord-010119-t1x9gknd 12589 19 staff staff NN cord-010119-t1x9gknd 12589 20 to to TO cord-010119-t1x9gknd 12589 21 promptly promptly RB cord-010119-t1x9gknd 12589 22 investigate investigate VB cord-010119-t1x9gknd 12589 23 and and CC cord-010119-t1x9gknd 12589 24 institute institute VB cord-010119-t1x9gknd 12589 25 corrective corrective JJ cord-010119-t1x9gknd 12589 26 / / SYM cord-010119-t1x9gknd 12589 27 preventive preventive JJ cord-010119-t1x9gknd 12589 28 actions action NNS cord-010119-t1x9gknd 12589 29 when when WRB cord-010119-t1x9gknd 12589 30 there there EX cord-010119-t1x9gknd 12589 31 is be VBZ cord-010119-t1x9gknd 12589 32 a a DT cord-010119-t1x9gknd 12589 33 deviation deviation NN cord-010119-t1x9gknd 12589 34 from from IN cord-010119-t1x9gknd 12589 35 policies policy NNS cord-010119-t1x9gknd 12589 36 related relate VBN cord-010119-t1x9gknd 12589 37 to to IN cord-010119-t1x9gknd 12589 38 specimen specimen JJ cord-010119-t1x9gknd 12589 39 collection collection NN cord-010119-t1x9gknd 12589 40 . . . cord-010119-t1x9gknd 12590 1 The the DT cord-010119-t1x9gknd 12590 2 heightened heightened JJ cord-010119-t1x9gknd 12590 3 awareness awareness NN cord-010119-t1x9gknd 12590 4 of of IN cord-010119-t1x9gknd 12590 5 correcting correct VBG cord-010119-t1x9gknd 12590 6 patient patient JJ cord-010119-t1x9gknd 12590 7 specimen specimen NN cord-010119-t1x9gknd 12590 8 labeling labeling NN cord-010119-t1x9gknd 12590 9 errors error NNS cord-010119-t1x9gknd 12590 10 can can MD cord-010119-t1x9gknd 12590 11 only only RB cord-010119-t1x9gknd 12590 12 improve improve VB cord-010119-t1x9gknd 12590 13 patient patient JJ cord-010119-t1x9gknd 12590 14 safety safety NN cord-010119-t1x9gknd 12590 15 and and CC cord-010119-t1x9gknd 12590 16 the the DT cord-010119-t1x9gknd 12590 17 patient patient JJ cord-010119-t1x9gknd 12590 18 experience experience NN cord-010119-t1x9gknd 12590 19 . . . cord-010119-t1x9gknd 12591 1 Platelet platelet NN cord-010119-t1x9gknd 12591 2 Transfusion transfusion NN cord-010119-t1x9gknd 12591 3 Practices Practices NNPS cord-010119-t1x9gknd 12591 4 Among among IN cord-010119-t1x9gknd 12591 5 Pediatric Pediatric NNP cord-010119-t1x9gknd 12591 6 Oncology Oncology NNP cord-010119-t1x9gknd 12591 7 Patients Patients NNP cord-010119-t1x9gknd 12591 8 : : : cord-010119-t1x9gknd 12592 1 A a DT cord-010119-t1x9gknd 12592 2 Single Single NNP cord-010119-t1x9gknd 12592 3 Institutional institutional JJ cord-010119-t1x9gknd 12592 4 Experience experience NN cord-010119-t1x9gknd 12593 1 Nicole Nicole NNP cord-010119-t1x9gknd 12593 2 M M NNP cord-010119-t1x9gknd 12593 3 Crews Crews NNPS cord-010119-t1x9gknd 12594 1 * * NFP cord-010119-t1x9gknd 12594 2 1,2 1,2 CD cord-010119-t1x9gknd 12594 3 , , , cord-010119-t1x9gknd 12594 4 Morgan Morgan NNP cord-010119-t1x9gknd 12594 5 Rockwell Rockwell NNP cord-010119-t1x9gknd 12594 6 2 2 CD cord-010119-t1x9gknd 12594 7 , , , cord-010119-t1x9gknd 12594 8 Joseph Joseph NNP cord-010119-t1x9gknd 12594 9 Hagan Hagan NNP cord-010119-t1x9gknd 12594 10 1 1 CD cord-010119-t1x9gknd 12594 11 , , , cord-010119-t1x9gknd 12594 12 Jun Jun NNP cord-010119-t1x9gknd 12594 13 Teruya Teruya NNP cord-010119-t1x9gknd 12594 14 1,2 1,2 CD cord-010119-t1x9gknd 12594 15 and and CC cord-010119-t1x9gknd 12594 16 Shiu Shiu NNP cord-010119-t1x9gknd 12594 17 - - HYPH cord-010119-t1x9gknd 12594 18 Ki Ki NNP cord-010119-t1x9gknd 12594 19 Hui Hui NNP cord-010119-t1x9gknd 12594 20 2 2 CD cord-010119-t1x9gknd 12594 21 . . . cord-010119-t1x9gknd 12595 1 1 1 LS cord-010119-t1x9gknd 12596 1 Texas Texas NNP cord-010119-t1x9gknd 12596 2 Children Children NNP cord-010119-t1x9gknd 12596 3 's 's POS cord-010119-t1x9gknd 12596 4 Hospital Hospital NNP cord-010119-t1x9gknd 12596 5 , , , cord-010119-t1x9gknd 12596 6 2 2 CD cord-010119-t1x9gknd 12596 7 Baylor Baylor NNP cord-010119-t1x9gknd 12596 8 College College NNP cord-010119-t1x9gknd 12596 9 of of IN cord-010119-t1x9gknd 12596 10 Medicine Medicine NNP cord-010119-t1x9gknd 12596 11 Background Background NNP cord-010119-t1x9gknd 12596 12 / / SYM cord-010119-t1x9gknd 12596 13 Case Case NNP cord-010119-t1x9gknd 12596 14 Studies Studies NNPS cord-010119-t1x9gknd 12596 15 : : : cord-010119-t1x9gknd 12596 16 Despite despite IN cord-010119-t1x9gknd 12596 17 advances advance NNS cord-010119-t1x9gknd 12596 18 in in IN cord-010119-t1x9gknd 12596 19 adult adult NN cord-010119-t1x9gknd 12596 20 platelet platelet NN cord-010119-t1x9gknd 12596 21 transfusion transfusion NN cord-010119-t1x9gknd 12596 22 ( ( -LRB- cord-010119-t1x9gknd 12596 23 PTx PTx NNS cord-010119-t1x9gknd 12596 24 ) ) -RRB- cord-010119-t1x9gknd 12596 25 literature literature NN cord-010119-t1x9gknd 12596 26 , , , cord-010119-t1x9gknd 12596 27 questions question NNS cord-010119-t1x9gknd 12596 28 persist persist VBP cord-010119-t1x9gknd 12596 29 regarding regard VBG cord-010119-t1x9gknd 12596 30 pediatric pediatric JJ cord-010119-t1x9gknd 12596 31 transfusion transfusion NN cord-010119-t1x9gknd 12596 32 thresholds threshold NNS cord-010119-t1x9gknd 12596 33 , , , cord-010119-t1x9gknd 12596 34 dosage dosage NN cord-010119-t1x9gknd 12596 35 and and CC cord-010119-t1x9gknd 12596 36 responses response NNS cord-010119-t1x9gknd 12596 37 . . . cord-010119-t1x9gknd 12597 1 Therefore therefore RB cord-010119-t1x9gknd 12597 2 , , , cord-010119-t1x9gknd 12597 3 PTx PTx NNS cord-010119-t1x9gknd 12597 4 are be VBP cord-010119-t1x9gknd 12597 5 commonly commonly RB cord-010119-t1x9gknd 12597 6 guided guide VBN cord-010119-t1x9gknd 12597 7 by by IN cord-010119-t1x9gknd 12597 8 local local JJ cord-010119-t1x9gknd 12597 9 institutional institutional JJ cord-010119-t1x9gknd 12597 10 recommendations recommendation NNS cord-010119-t1x9gknd 12597 11 ( ( -LRB- cord-010119-t1x9gknd 12597 12 IR IR NNP cord-010119-t1x9gknd 12597 13 ) ) -RRB- cord-010119-t1x9gknd 12597 14 . . . cord-010119-t1x9gknd 12598 1 The the DT cord-010119-t1x9gknd 12598 2 aim aim NN cord-010119-t1x9gknd 12598 3 of of IN cord-010119-t1x9gknd 12598 4 this this DT cord-010119-t1x9gknd 12598 5 study study NN cord-010119-t1x9gknd 12598 6 was be VBD cord-010119-t1x9gknd 12598 7 to to TO cord-010119-t1x9gknd 12598 8 determine determine VB cord-010119-t1x9gknd 12598 9 the the DT cord-010119-t1x9gknd 12598 10 degree degree NN cord-010119-t1x9gknd 12598 11 of of IN cord-010119-t1x9gknd 12598 12 adherence adherence NN cord-010119-t1x9gknd 12598 13 of of IN cord-010119-t1x9gknd 12598 14 PTx PTx NNS cord-010119-t1x9gknd 12598 15 practice practice NN cord-010119-t1x9gknd 12598 16 to to IN cord-010119-t1x9gknd 12598 17 IR IR NNP cord-010119-t1x9gknd 12598 18 at at IN cord-010119-t1x9gknd 12598 19 a a DT cord-010119-t1x9gknd 12598 20 pediatric pediatric JJ cord-010119-t1x9gknd 12598 21 tertiary tertiary JJ cord-010119-t1x9gknd 12598 22 institution institution NN cord-010119-t1x9gknd 12598 23 . . . cord-010119-t1x9gknd 12599 1 Study Study NNP cord-010119-t1x9gknd 12599 2 Design Design NNP cord-010119-t1x9gknd 12599 3 / / SYM cord-010119-t1x9gknd 12599 4 Method method NN cord-010119-t1x9gknd 12599 5 : : : cord-010119-t1x9gknd 12600 1 Retrospective retrospective JJ cord-010119-t1x9gknd 12600 2 review review NN cord-010119-t1x9gknd 12600 3 of of IN cord-010119-t1x9gknd 12600 4 PTx PTx NNS cord-010119-t1x9gknd 12600 5 practices practice NNS cord-010119-t1x9gknd 12600 6 including include VBG cord-010119-t1x9gknd 12600 7 transfusion transfusion NN cord-010119-t1x9gknd 12600 8 thresholds threshold NNS cord-010119-t1x9gknd 12600 9 , , , cord-010119-t1x9gknd 12600 10 responses response NNS cord-010119-t1x9gknd 12600 11 and and CC cord-010119-t1x9gknd 12600 12 dosages dosage NNS cord-010119-t1x9gknd 12600 13 were be VBD cord-010119-t1x9gknd 12600 14 collected collect VBN cord-010119-t1x9gknd 12600 15 . . . cord-010119-t1x9gknd 12601 1 Platelet platelet NN cord-010119-t1x9gknd 12601 2 counts count VBZ cord-010119-t1x9gknd 12601 3 within within IN cord-010119-t1x9gknd 12601 4 24 24 CD cord-010119-t1x9gknd 12601 5 hours hour NNS cord-010119-t1x9gknd 12601 6 pre pre VBP cord-010119-t1x9gknd 12601 7 and and CC cord-010119-t1x9gknd 12601 8 post post JJ cord-010119-t1x9gknd 12601 9 transfusion transfusion NN cord-010119-t1x9gknd 12601 10 were be VBD cord-010119-t1x9gknd 12601 11 evaluated evaluate VBN cord-010119-t1x9gknd 12601 12 . . . cord-010119-t1x9gknd 12602 1 Patients patient NNS cord-010119-t1x9gknd 12602 2 ( ( -LRB- cord-010119-t1x9gknd 12602 3 0 0 CD cord-010119-t1x9gknd 12602 4 - - SYM cord-010119-t1x9gknd 12602 5 18 18 CD cord-010119-t1x9gknd 12602 6 years year NNS cord-010119-t1x9gknd 12602 7 ) ) -RRB- cord-010119-t1x9gknd 12602 8 receiving receive VBG cord-010119-t1x9gknd 12602 9 prophylactic prophylactic JJ cord-010119-t1x9gknd 12602 10 PTx PTx NNS cord-010119-t1x9gknd 12602 11 from from IN cord-010119-t1x9gknd 12602 12 July July NNP cord-010119-t1x9gknd 12602 13 to to IN cord-010119-t1x9gknd 12602 14 December December NNP cord-010119-t1x9gknd 12602 15 2016 2016 CD cord-010119-t1x9gknd 12602 16 admitted admit VBD cord-010119-t1x9gknd 12602 17 to to IN cord-010119-t1x9gknd 12602 18 the the DT cord-010119-t1x9gknd 12602 19 oncology oncology NN cord-010119-t1x9gknd 12602 20 acute acute JJ cord-010119-t1x9gknd 12602 21 care care NN cord-010119-t1x9gknd 12602 22 unit unit NN cord-010119-t1x9gknd 12602 23 with with IN cord-010119-t1x9gknd 12602 24 diagnosis diagnosis NN cord-010119-t1x9gknd 12602 25 of of IN cord-010119-t1x9gknd 12602 26 leukemia leukemia NN cord-010119-t1x9gknd 12602 27 or or CC cord-010119-t1x9gknd 12602 28 lymphoma lymphoma NN cord-010119-t1x9gknd 12602 29 were be VBD cord-010119-t1x9gknd 12602 30 included include VBN cord-010119-t1x9gknd 12602 31 . . . cord-010119-t1x9gknd 12603 1 For for IN cord-010119-t1x9gknd 12603 2 prevention prevention NN cord-010119-t1x9gknd 12603 3 of of IN cord-010119-t1x9gknd 12603 4 volume volume NN cord-010119-t1x9gknd 12603 5 overload overload NN cord-010119-t1x9gknd 12603 6 , , , cord-010119-t1x9gknd 12603 7 the the DT cord-010119-t1x9gknd 12603 8 IR IR NNP cord-010119-t1x9gknd 12603 9 for for IN cord-010119-t1x9gknd 12603 10 PTx PTx NNS cord-010119-t1x9gknd 12603 11 were be VBD cord-010119-t1x9gknd 12603 12 < < XX cord-010119-t1x9gknd 12603 13 10ml 10ml NNP cord-010119-t1x9gknd 12603 14 / / SYM cord-010119-t1x9gknd 12603 15 kg kg NN cord-010119-t1x9gknd 12603 16 for for IN cord-010119-t1x9gknd 12603 17 patients patient NNS cord-010119-t1x9gknd 12603 18 < < NNP cord-010119-t1x9gknd 12603 19 35 35 CD cord-010119-t1x9gknd 12603 20 kg kg NNS cord-010119-t1x9gknd 12603 21 and and CC cord-010119-t1x9gknd 12603 22 one one CD cord-010119-t1x9gknd 12603 23 apheresis apheresis NN cord-010119-t1x9gknd 12603 24 unit unit NN cord-010119-t1x9gknd 12603 25 ( ( -LRB- cord-010119-t1x9gknd 12603 26 AU AU NNP cord-010119-t1x9gknd 12603 27 ) ) -RRB- cord-010119-t1x9gknd 12603 28 for for IN cord-010119-t1x9gknd 12603 29 patients patient NNS cord-010119-t1x9gknd 12603 30 > > NNS cord-010119-t1x9gknd 12603 31 35 35 CD cord-010119-t1x9gknd 12603 32 kg kg NNS cord-010119-t1x9gknd 12603 33 ; ; : cord-010119-t1x9gknd 12603 34 therefore therefore RB cord-010119-t1x9gknd 12603 35 , , , cord-010119-t1x9gknd 12603 36 patients patient NNS cord-010119-t1x9gknd 12603 37 were be VBD cord-010119-t1x9gknd 12603 38 separated separate VBN cord-010119-t1x9gknd 12603 39 into into IN cord-010119-t1x9gknd 12603 40 2 2 CD cord-010119-t1x9gknd 12603 41 groups group NNS cord-010119-t1x9gknd 12603 42 : : : cord-010119-t1x9gknd 12603 43 < < XX cord-010119-t1x9gknd 12603 44 35 35 CD cord-010119-t1x9gknd 12603 45 kg kg NNS cord-010119-t1x9gknd 12603 46 and and CC cord-010119-t1x9gknd 12603 47 > > NFP cord-010119-t1x9gknd 12603 48 35 35 CD cord-010119-t1x9gknd 12603 49 kg kg NNS cord-010119-t1x9gknd 12603 50 . . . cord-010119-t1x9gknd 12604 1 A a DT cord-010119-t1x9gknd 12604 2 significant significant JJ cord-010119-t1x9gknd 12604 3 proportion proportion NN cord-010119-t1x9gknd 12604 4 of of IN cord-010119-t1x9gknd 12604 5 orders order NNS cord-010119-t1x9gknd 12604 6 for for IN cord-010119-t1x9gknd 12604 7 both both CC cord-010119-t1x9gknd 12604 8 < < XX cord-010119-t1x9gknd 12604 9 35 35 CD cord-010119-t1x9gknd 12604 10 kg kg NNS cord-010119-t1x9gknd 12604 11 and and CC cord-010119-t1x9gknd 12604 12 > > NFP cord-010119-t1x9gknd 12604 13 35 35 CD cord-010119-t1x9gknd 12604 14 kg kg NNS cord-010119-t1x9gknd 12604 15 did do VBD cord-010119-t1x9gknd 12604 16 not not RB cord-010119-t1x9gknd 12604 17 meet meet VB cord-010119-t1x9gknd 12604 18 patient patient JJ cord-010119-t1x9gknd 12604 19 platelet platelet NN cord-010119-t1x9gknd 12604 20 threshold threshold NN cord-010119-t1x9gknd 12604 21 criteria criterion NNS cord-010119-t1x9gknd 12604 22 ( ( -LRB- cord-010119-t1x9gknd 12604 23 p<0.001 p<0.001 CD cord-010119-t1x9gknd 12604 24 ) ) -RRB- cord-010119-t1x9gknd 12604 25 . . . cord-010119-t1x9gknd 12605 1 Conclusion conclusion NN cord-010119-t1x9gknd 12605 2 : : : cord-010119-t1x9gknd 12606 1 PTx PTx NNS cord-010119-t1x9gknd 12606 2 threshold threshold NN cord-010119-t1x9gknd 12606 3 above above IN cord-010119-t1x9gknd 12606 4 IR IR NNP cord-010119-t1x9gknd 12606 5 for for IN cord-010119-t1x9gknd 12606 6 both both DT cord-010119-t1x9gknd 12606 7 groups group NNS cord-010119-t1x9gknd 12606 8 were be VBD cord-010119-t1x9gknd 12606 9 31 31 CD cord-010119-t1x9gknd 12606 10 ( ( -LRB- cord-010119-t1x9gknd 12606 11 35 35 CD cord-010119-t1x9gknd 12606 12 kg kg NNS cord-010119-t1x9gknd 12606 13 ) ) -RRB- cord-010119-t1x9gknd 12606 14 and and CC cord-010119-t1x9gknd 12606 15 48 48 CD cord-010119-t1x9gknd 12606 16 % % NN cord-010119-t1x9gknd 12606 17 ( ( -LRB- cord-010119-t1x9gknd 12606 18 > > NFP cord-010119-t1x9gknd 12606 19 35 35 CD cord-010119-t1x9gknd 12606 20 kg kg NNP cord-010119-t1x9gknd 12606 21 ) ) -RRB- cord-010119-t1x9gknd 12606 22 . . . cord-010119-t1x9gknd 12607 1 Most Most JJS cord-010119-t1x9gknd 12607 2 common common JJ cord-010119-t1x9gknd 12607 3 reason reason NN cord-010119-t1x9gknd 12607 4 for for IN cord-010119-t1x9gknd 12607 5 above above IN cord-010119-t1x9gknd 12607 6 IR IR NNP cord-010119-t1x9gknd 12607 7 threshold threshold NN cord-010119-t1x9gknd 12607 8 was be VBD cord-010119-t1x9gknd 12607 9 an an DT cord-010119-t1x9gknd 12607 10 invasive invasive JJ cord-010119-t1x9gknd 12607 11 procedure procedure NN cord-010119-t1x9gknd 12607 12 or or CC cord-010119-t1x9gknd 12607 13 low low JJ cord-010119-t1x9gknd 12607 14 molecular molecular JJ cord-010119-t1x9gknd 12607 15 weight weight NN cord-010119-t1x9gknd 12607 16 heparin heparin NN cord-010119-t1x9gknd 12607 17 therapy therapy NN cord-010119-t1x9gknd 12607 18 . . . cord-010119-t1x9gknd 12608 1 Greater great JJR cord-010119-t1x9gknd 12608 2 than than IN cord-010119-t1x9gknd 12608 3 10 10 CD cord-010119-t1x9gknd 12608 4 % % NN cord-010119-t1x9gknd 12608 5 of of IN cord-010119-t1x9gknd 12608 6 PTx PTx NNS cord-010119-t1x9gknd 12608 7 dosage dosage VBP cord-010119-t1x9gknd 12608 8 in in IN cord-010119-t1x9gknd 12608 9 both both DT cord-010119-t1x9gknd 12608 10 groups group NNS cord-010119-t1x9gknd 12608 11 were be VBD cord-010119-t1x9gknd 12608 12 above above IN cord-010119-t1x9gknd 12608 13 IR IR NNP cord-010119-t1x9gknd 12608 14 , , , cord-010119-t1x9gknd 12608 15 however however RB cord-010119-t1x9gknd 12608 16 the the DT cord-010119-t1x9gknd 12608 17 platelet platelet NN cord-010119-t1x9gknd 12608 18 response response NN cord-010119-t1x9gknd 12608 19 did do VBD cord-010119-t1x9gknd 12608 20 not not RB cord-010119-t1x9gknd 12608 21 increase increase VB cord-010119-t1x9gknd 12608 22 significantly significantly RB cord-010119-t1x9gknd 12608 23 ( ( -LRB- cord-010119-t1x9gknd 12608 24 p>0.05 p>0.05 NNP cord-010119-t1x9gknd 12608 25 ) ) -RRB- cord-010119-t1x9gknd 12608 26 with with IN cord-010119-t1x9gknd 12608 27 a a DT cord-010119-t1x9gknd 12608 28 higher high JJR cord-010119-t1x9gknd 12608 29 dose dose NN cord-010119-t1x9gknd 12608 30 vs. vs. IN cord-010119-t1x9gknd 12608 31 IR IR NNP cord-010119-t1x9gknd 12608 32 dose dose NN cord-010119-t1x9gknd 12608 33 . . . cord-010119-t1x9gknd 12609 1 This this DT cord-010119-t1x9gknd 12609 2 study study NN cord-010119-t1x9gknd 12609 3 demonstrated demonstrate VBD cord-010119-t1x9gknd 12609 4 that that IN cord-010119-t1x9gknd 12609 5 there there EX cord-010119-t1x9gknd 12609 6 were be VBD cord-010119-t1x9gknd 12609 7 still still RB cord-010119-t1x9gknd 12609 8 considerable considerable JJ cord-010119-t1x9gknd 12609 9 deviations deviation NNS cord-010119-t1x9gknd 12609 10 from from IN cord-010119-t1x9gknd 12609 11 IR IR NNP cord-010119-t1x9gknd 12609 12 in in IN cord-010119-t1x9gknd 12609 13 PTx PTx NNS cord-010119-t1x9gknd 12609 14 practice practice NN cord-010119-t1x9gknd 12609 15 among among IN cord-010119-t1x9gknd 12609 16 pediatric pediatric JJ cord-010119-t1x9gknd 12609 17 oncological oncological JJ cord-010119-t1x9gknd 12609 18 patients patient NNS cord-010119-t1x9gknd 12609 19 . . . cord-010119-t1x9gknd 12610 1 In in IN cord-010119-t1x9gknd 12610 2 addition addition NN cord-010119-t1x9gknd 12610 3 , , , cord-010119-t1x9gknd 12610 4 the the DT cord-010119-t1x9gknd 12610 5 false false JJ cord-010119-t1x9gknd 12610 6 assumption assumption NN cord-010119-t1x9gknd 12610 7 that that IN cord-010119-t1x9gknd 12610 8 a a DT cord-010119-t1x9gknd 12610 9 higher high JJR cord-010119-t1x9gknd 12610 10 dose dose NN cord-010119-t1x9gknd 12610 11 will will MD cord-010119-t1x9gknd 12610 12 yield yield VB cord-010119-t1x9gknd 12610 13 a a DT cord-010119-t1x9gknd 12610 14 better well JJR cord-010119-t1x9gknd 12610 15 response response NN cord-010119-t1x9gknd 12610 16 can can MD cord-010119-t1x9gknd 12610 17 put put VB cord-010119-t1x9gknd 12610 18 patients patient NNS cord-010119-t1x9gknd 12610 19 at at IN cord-010119-t1x9gknd 12610 20 increased increase VBN cord-010119-t1x9gknd 12610 21 risk risk NN cord-010119-t1x9gknd 12610 22 for for IN cord-010119-t1x9gknd 12610 23 transfusion transfusion NN cord-010119-t1x9gknd 12610 24 related relate VBD cord-010119-t1x9gknd 12610 25 adverse adverse JJ cord-010119-t1x9gknd 12610 26 events event NNS cord-010119-t1x9gknd 12610 27 . . . cord-010119-t1x9gknd 12611 1 Each each DT cord-010119-t1x9gknd 12611 2 institution institution NN cord-010119-t1x9gknd 12611 3 should should MD cord-010119-t1x9gknd 12611 4 conduct conduct VB cord-010119-t1x9gknd 12611 5 a a DT cord-010119-t1x9gknd 12611 6 quality quality NN cord-010119-t1x9gknd 12611 7 assurance assurance NN cord-010119-t1x9gknd 12611 8 review review NN cord-010119-t1x9gknd 12611 9 to to TO cord-010119-t1x9gknd 12611 10 determine determine VB cord-010119-t1x9gknd 12611 11 PTx PTx NNS cord-010119-t1x9gknd 12611 12 practice practice VB cord-010119-t1x9gknd 12611 13 . . . cord-010119-t1x9gknd 12612 1 Pre pre JJ cord-010119-t1x9gknd 12612 2 - - JJ cord-010119-t1x9gknd 12612 3 Surgical surgical JJ cord-010119-t1x9gknd 12612 4 Sample sample NN cord-010119-t1x9gknd 12612 5 Process process NN cord-010119-t1x9gknd 12612 6 Improvement improvement NN cord-010119-t1x9gknd 12612 7 to to TO cord-010119-t1x9gknd 12612 8 Enhance enhance VB cord-010119-t1x9gknd 12612 9 Patient Patient NNP cord-010119-t1x9gknd 12612 10 Safety Safety NNP cord-010119-t1x9gknd 12612 11 and and CC cord-010119-t1x9gknd 12612 12 Compliance Compliance NNP cord-010119-t1x9gknd 12612 13 Lisa Lisa NNP cord-010119-t1x9gknd 12612 14 Marie Marie NNP cord-010119-t1x9gknd 12612 15 Button Button NNP cord-010119-t1x9gknd 12613 1 * * NFP cord-010119-t1x9gknd 12613 2 , , , cord-010119-t1x9gknd 12613 3 Stephanie Stephanie NNP cord-010119-t1x9gknd 12613 4 Saathoff Saathoff NNP cord-010119-t1x9gknd 12613 5 , , , cord-010119-t1x9gknd 12613 6 Jered Jered NNP cord-010119-t1x9gknd 12613 7 Luedke Luedke NNP cord-010119-t1x9gknd 12613 8 , , , cord-010119-t1x9gknd 12613 9 Benjamin Benjamin NNP cord-010119-t1x9gknd 12613 10 Colvin Colvin NNP cord-010119-t1x9gknd 12613 11 , , , cord-010119-t1x9gknd 12613 12 Umalkair Umalkair NNP cord-010119-t1x9gknd 12613 13 Amare Amare NNP cord-010119-t1x9gknd 12613 14 and and CC cord-010119-t1x9gknd 12613 15 James James NNP cord-010119-t1x9gknd 12613 16 R R NNP cord-010119-t1x9gknd 12613 17 Stubbs Stubbs NNP cord-010119-t1x9gknd 12613 18 . . . cord-010119-t1x9gknd 12614 1 Mayo Mayo NNP cord-010119-t1x9gknd 12614 2 Clinic Clinic NNP cord-010119-t1x9gknd 12614 3 Background Background NNP cord-010119-t1x9gknd 12614 4 / / SYM cord-010119-t1x9gknd 12614 5 Case Case NNP cord-010119-t1x9gknd 12614 6 Studies Studies NNPS cord-010119-t1x9gknd 12615 1 : : : cord-010119-t1x9gknd 12615 2 Our -PRON- PRP$ cord-010119-t1x9gknd 12615 3 institution institution NN cord-010119-t1x9gknd 12615 4 provides provide VBZ cord-010119-t1x9gknd 12615 5 the the DT cord-010119-t1x9gknd 12615 6 option option NN cord-010119-t1x9gknd 12615 7 for for IN cord-010119-t1x9gknd 12615 8 presurgical presurgical JJ cord-010119-t1x9gknd 12615 9 samples sample NNS cord-010119-t1x9gknd 12615 10 ( ( -LRB- cord-010119-t1x9gknd 12615 11 PSS PSS NNP cord-010119-t1x9gknd 12615 12 ) ) -RRB- cord-010119-t1x9gknd 12615 13 to to TO cord-010119-t1x9gknd 12615 14 be be VB cord-010119-t1x9gknd 12615 15 drawn draw VBN cord-010119-t1x9gknd 12615 16 up up RP cord-010119-t1x9gknd 12615 17 to to TO cord-010119-t1x9gknd 12615 18 56 56 CD cord-010119-t1x9gknd 12615 19 days day NNS cord-010119-t1x9gknd 12615 20 prior prior RB cord-010119-t1x9gknd 12615 21 to to IN cord-010119-t1x9gknd 12615 22 surgery surgery NN cord-010119-t1x9gknd 12615 23 as as RB cord-010119-t1x9gknd 12615 24 long long RB cord-010119-t1x9gknd 12615 25 as as IN cord-010119-t1x9gknd 12615 26 the the DT cord-010119-t1x9gknd 12615 27 patient patient NN cord-010119-t1x9gknd 12615 28 reports report VBZ cord-010119-t1x9gknd 12615 29 not not RB cord-010119-t1x9gknd 12615 30 being be VBG cord-010119-t1x9gknd 12615 31 transfused transfuse VBN cord-010119-t1x9gknd 12615 32 with with IN cord-010119-t1x9gknd 12615 33 a a DT cord-010119-t1x9gknd 12615 34 blood blood NN cord-010119-t1x9gknd 12615 35 or or CC cord-010119-t1x9gknd 12615 36 blood blood NN cord-010119-t1x9gknd 12615 37 component component NN cord-010119-t1x9gknd 12615 38 containing contain VBG cord-010119-t1x9gknd 12615 39 allogeneic allogeneic JJ cord-010119-t1x9gknd 12615 40 red red JJ cord-010119-t1x9gknd 12615 41 cells cell NNS cord-010119-t1x9gknd 12615 42 and and CC cord-010119-t1x9gknd 12615 43 they -PRON- PRP cord-010119-t1x9gknd 12615 44 have have VBP cord-010119-t1x9gknd 12615 45 not not RB cord-010119-t1x9gknd 12615 46 been be VBN cord-010119-t1x9gknd 12615 47 pregnant pregnant JJ cord-010119-t1x9gknd 12615 48 in in IN cord-010119-t1x9gknd 12615 49 the the DT cord-010119-t1x9gknd 12615 50 preceding precede VBG cord-010119-t1x9gknd 12615 51 3 3 CD cord-010119-t1x9gknd 12615 52 months month NNS cord-010119-t1x9gknd 12615 53 from from IN cord-010119-t1x9gknd 12615 54 the the DT cord-010119-t1x9gknd 12615 55 date date NN cord-010119-t1x9gknd 12615 56 of of IN cord-010119-t1x9gknd 12615 57 PSS PSS NNP cord-010119-t1x9gknd 12615 58 collection collection NN cord-010119-t1x9gknd 12615 59 . . . cord-010119-t1x9gknd 12616 1 When when WRB cord-010119-t1x9gknd 12616 2 PSS PSS NNP cord-010119-t1x9gknd 12616 3 patients patient NNS cord-010119-t1x9gknd 12616 4 returned return VBD cord-010119-t1x9gknd 12616 5 for for IN cord-010119-t1x9gknd 12616 6 surgery surgery NN cord-010119-t1x9gknd 12616 7 , , , cord-010119-t1x9gknd 12616 8 the the DT cord-010119-t1x9gknd 12616 9 patient patient NN cord-010119-t1x9gknd 12616 10 's 's POS cord-010119-t1x9gknd 12616 11 service service NN cord-010119-t1x9gknd 12616 12 was be VBD cord-010119-t1x9gknd 12616 13 required require VBN cord-010119-t1x9gknd 12616 14 to to TO cord-010119-t1x9gknd 12616 15 ask ask VB cord-010119-t1x9gknd 12616 16 the the DT cord-010119-t1x9gknd 12616 17 patient patient NN cord-010119-t1x9gknd 12616 18 again again RB cord-010119-t1x9gknd 12616 19 about about IN cord-010119-t1x9gknd 12616 20 their -PRON- PRP$ cord-010119-t1x9gknd 12616 21 transfusion transfusion NN cord-010119-t1x9gknd 12616 22 and and CC cord-010119-t1x9gknd 12616 23 pregnancy pregnancy NN cord-010119-t1x9gknd 12616 24 history history NN cord-010119-t1x9gknd 12616 25 to to TO cord-010119-t1x9gknd 12616 26 determine determine VB cord-010119-t1x9gknd 12616 27 if if IN cord-010119-t1x9gknd 12616 28 there there EX cord-010119-t1x9gknd 12616 29 had have VBD cord-010119-t1x9gknd 12616 30 been be VBN cord-010119-t1x9gknd 12616 31 any any DT cord-010119-t1x9gknd 12616 32 new new JJ cord-010119-t1x9gknd 12616 33 opportunities opportunity NNS cord-010119-t1x9gknd 12616 34 for for IN cord-010119-t1x9gknd 12616 35 allogeneic allogeneic JJ cord-010119-t1x9gknd 12616 36 red red JJ cord-010119-t1x9gknd 12616 37 cell cell NN cord-010119-t1x9gknd 12616 38 exposure exposure NN cord-010119-t1x9gknd 12616 39 , , , cord-010119-t1x9gknd 12616 40 however however RB cord-010119-t1x9gknd 12616 41 , , , cord-010119-t1x9gknd 12616 42 there there EX cord-010119-t1x9gknd 12616 43 was be VBD cord-010119-t1x9gknd 12616 44 no no DT cord-010119-t1x9gknd 12616 45 process process NN cord-010119-t1x9gknd 12616 46 to to TO cord-010119-t1x9gknd 12616 47 capture capture VB cord-010119-t1x9gknd 12616 48 the the DT cord-010119-t1x9gknd 12616 49 information information NN cord-010119-t1x9gknd 12616 50 the the DT cord-010119-t1x9gknd 12616 51 patient patient NN cord-010119-t1x9gknd 12616 52 reported report VBD cord-010119-t1x9gknd 12616 53 for for IN cord-010119-t1x9gknd 12616 54 the the DT cord-010119-t1x9gknd 12616 55 time time NN cord-010119-t1x9gknd 12616 56 between between IN cord-010119-t1x9gknd 12616 57 the the DT cord-010119-t1x9gknd 12616 58 PSS PSS NNP cord-010119-t1x9gknd 12616 59 draw draw VB cord-010119-t1x9gknd 12616 60 to to IN cord-010119-t1x9gknd 12616 61 the the DT cord-010119-t1x9gknd 12616 62 day day NN cord-010119-t1x9gknd 12616 63 of of IN cord-010119-t1x9gknd 12616 64 surgery surgery NN cord-010119-t1x9gknd 12616 65 / / SYM cord-010119-t1x9gknd 12616 66 possible possible JJ cord-010119-t1x9gknd 12616 67 transfusion transfusion NN cord-010119-t1x9gknd 12616 68 . . . cord-010119-t1x9gknd 12617 1 Study Study NNP cord-010119-t1x9gknd 12617 2 Design Design NNP cord-010119-t1x9gknd 12617 3 / / SYM cord-010119-t1x9gknd 12617 4 Method method NN cord-010119-t1x9gknd 12617 5 : : : cord-010119-t1x9gknd 12618 1 An an DT cord-010119-t1x9gknd 12618 2 electronic electronic JJ cord-010119-t1x9gknd 12618 3 fix fix NN cord-010119-t1x9gknd 12618 4 was be VBD cord-010119-t1x9gknd 12618 5 designed design VBN cord-010119-t1x9gknd 12618 6 that that WDT cord-010119-t1x9gknd 12618 7 was be VBD cord-010119-t1x9gknd 12618 8 applied apply VBN cord-010119-t1x9gknd 12618 9 to to IN cord-010119-t1x9gknd 12618 10 the the DT cord-010119-t1x9gknd 12618 11 surgical surgical JJ cord-010119-t1x9gknd 12618 12 intake intake NN cord-010119-t1x9gknd 12618 13 process process NN cord-010119-t1x9gknd 12618 14 . . . cord-010119-t1x9gknd 12619 1 A a DT cord-010119-t1x9gknd 12619 2 new new JJ cord-010119-t1x9gknd 12619 3 set set NN cord-010119-t1x9gknd 12619 4 of of IN cord-010119-t1x9gknd 12619 5 questions question NNS cord-010119-t1x9gknd 12619 6 was be VBD cord-010119-t1x9gknd 12619 7 added add VBN cord-010119-t1x9gknd 12619 8 to to IN cord-010119-t1x9gknd 12619 9 the the DT cord-010119-t1x9gknd 12619 10 A.M. A.M. NNP cord-010119-t1x9gknd 12619 11 Admit Admit NNP cord-010119-t1x9gknd 12619 12 questionnaire questionnaire NN cord-010119-t1x9gknd 12619 13 that that WDT cord-010119-t1x9gknd 12619 14 must must MD cord-010119-t1x9gknd 12619 15 be be VB cord-010119-t1x9gknd 12619 16 completed complete VBN cord-010119-t1x9gknd 12619 17 prior prior RB cord-010119-t1x9gknd 12619 18 to to IN cord-010119-t1x9gknd 12619 19 the the DT cord-010119-t1x9gknd 12619 20 patient patient NN cord-010119-t1x9gknd 12619 21 's 's POS cord-010119-t1x9gknd 12619 22 surgical surgical JJ cord-010119-t1x9gknd 12619 23 procedure procedure NN cord-010119-t1x9gknd 12619 24 . . . cord-010119-t1x9gknd 12620 1 The the DT cord-010119-t1x9gknd 12620 2 questions question NNS cord-010119-t1x9gknd 12620 3 ask ask VBP cord-010119-t1x9gknd 12620 4 the the DT cord-010119-t1x9gknd 12620 5 patient patient NN cord-010119-t1x9gknd 12620 6 if if IN cord-010119-t1x9gknd 12620 7 they -PRON- PRP cord-010119-t1x9gknd 12620 8 have have VBP cord-010119-t1x9gknd 12620 9 been be VBN cord-010119-t1x9gknd 12620 10 pregnant pregnant JJ cord-010119-t1x9gknd 12620 11 or or CC cord-010119-t1x9gknd 12620 12 transfused transfuse VBN cord-010119-t1x9gknd 12620 13 in in IN cord-010119-t1x9gknd 12620 14 the the DT cord-010119-t1x9gknd 12620 15 preceding precede VBG cord-010119-t1x9gknd 12620 16 three three CD cord-010119-t1x9gknd 12620 17 months month NNS cord-010119-t1x9gknd 12620 18 and and CC cord-010119-t1x9gknd 12620 19 if if IN cord-010119-t1x9gknd 12620 20 the the DT cord-010119-t1x9gknd 12620 21 answer answer NN cord-010119-t1x9gknd 12620 22 is be VBZ cord-010119-t1x9gknd 12620 23 affirmative affirmative JJ cord-010119-t1x9gknd 12620 24 , , , cord-010119-t1x9gknd 12620 25 the the DT cord-010119-t1x9gknd 12620 26 computer computer NN cord-010119-t1x9gknd 12620 27 system system NN cord-010119-t1x9gknd 12620 28 runs run VBZ cord-010119-t1x9gknd 12620 29 a a DT cord-010119-t1x9gknd 12620 30 blaze blaze NN cord-010119-t1x9gknd 12620 31 rule rule NN cord-010119-t1x9gknd 12620 32 causing cause VBG cord-010119-t1x9gknd 12620 33 an an DT cord-010119-t1x9gknd 12620 34 alert alert NN cord-010119-t1x9gknd 12620 35 in in IN cord-010119-t1x9gknd 12620 36 the the DT cord-010119-t1x9gknd 12620 37 blood blood NN cord-010119-t1x9gknd 12620 38 bank bank NN cord-010119-t1x9gknd 12620 39 . . . cord-010119-t1x9gknd 12621 1 The the DT cord-010119-t1x9gknd 12621 2 blood blood NN cord-010119-t1x9gknd 12621 3 bank bank NN cord-010119-t1x9gknd 12621 4 techs tech NNS cord-010119-t1x9gknd 12621 5 review review VBP cord-010119-t1x9gknd 12621 6 the the DT cord-010119-t1x9gknd 12621 7 alert alert NN cord-010119-t1x9gknd 12621 8 and and CC cord-010119-t1x9gknd 12621 9 inactivate inactivate VB cord-010119-t1x9gknd 12621 10 the the DT cord-010119-t1x9gknd 12621 11 patient patient NN cord-010119-t1x9gknd 12621 12 's 's POS cord-010119-t1x9gknd 12621 13 PSS PSS NNP cord-010119-t1x9gknd 12621 14 based base VBN cord-010119-t1x9gknd 12621 15 on on IN cord-010119-t1x9gknd 12621 16 the the DT cord-010119-t1x9gknd 12621 17 new new JJ cord-010119-t1x9gknd 12621 18 transfusion transfusion NN cord-010119-t1x9gknd 12621 19 / / SYM cord-010119-t1x9gknd 12621 20 pregnany pregnany JJ cord-010119-t1x9gknd 12621 21 information information NN cord-010119-t1x9gknd 12621 22 . . . cord-010119-t1x9gknd 12622 1 One one CD cord-010119-t1x9gknd 12622 2 year year NN cord-010119-t1x9gknd 12622 3 post post NN cord-010119-t1x9gknd 12622 4 - - NN cord-010119-t1x9gknd 12622 5 implementation implementation NN cord-010119-t1x9gknd 12622 6 of of IN cord-010119-t1x9gknd 12622 7 the the DT cord-010119-t1x9gknd 12622 8 electronic electronic JJ cord-010119-t1x9gknd 12622 9 fix fix NN cord-010119-t1x9gknd 12622 10 , , , cord-010119-t1x9gknd 12622 11 Transfusion Transfusion NNP cord-010119-t1x9gknd 12622 12 Lab Lab NNP cord-010119-t1x9gknd 12622 13 performed perform VBD cord-010119-t1x9gknd 12622 14 a a DT cord-010119-t1x9gknd 12622 15 retrospective retrospective JJ cord-010119-t1x9gknd 12622 16 review review NN cord-010119-t1x9gknd 12622 17 of of IN cord-010119-t1x9gknd 12622 18 all all DT cord-010119-t1x9gknd 12622 19 PSS PSS NNP cord-010119-t1x9gknd 12622 20 alerts alert NNS cord-010119-t1x9gknd 12622 21 generated generate VBN cord-010119-t1x9gknd 12622 22 during during IN cord-010119-t1x9gknd 12622 23 a a DT cord-010119-t1x9gknd 12622 24 three three CD cord-010119-t1x9gknd 12622 25 - - HYPH cord-010119-t1x9gknd 12622 26 month month NN cord-010119-t1x9gknd 12622 27 period period NN cord-010119-t1x9gknd 12622 28 . . . cord-010119-t1x9gknd 12623 1 Results/ Results/ . cord-010119-t1x9gknd 12624 1 Finding find VBG cord-010119-t1x9gknd 12624 2 : : : cord-010119-t1x9gknd 12624 3 The the DT cord-010119-t1x9gknd 12624 4 results result NNS cord-010119-t1x9gknd 12624 5 of of IN cord-010119-t1x9gknd 12624 6 the the DT cord-010119-t1x9gknd 12624 7 review review NN cord-010119-t1x9gknd 12624 8 were be VBD cord-010119-t1x9gknd 12624 9 analyzed analyze VBN cord-010119-t1x9gknd 12624 10 and and CC cord-010119-t1x9gknd 12624 11 are be VBP cord-010119-t1x9gknd 12624 12 displayed display VBN cord-010119-t1x9gknd 12624 13 in in IN cord-010119-t1x9gknd 12624 14 the the DT cord-010119-t1x9gknd 12624 15 Table table NN cord-010119-t1x9gknd 12624 16 . . . cord-010119-t1x9gknd 12625 1 It -PRON- PRP cord-010119-t1x9gknd 12625 2 was be VBD cord-010119-t1x9gknd 12625 3 determined determine VBN cord-010119-t1x9gknd 12625 4 that that IN cord-010119-t1x9gknd 12625 5 only only RB cord-010119-t1x9gknd 12625 6 2.1 2.1 CD cord-010119-t1x9gknd 12625 7 % % NN cord-010119-t1x9gknd 12625 8 of of IN cord-010119-t1x9gknd 12625 9 patients patient NNS cord-010119-t1x9gknd 12625 10 with with IN cord-010119-t1x9gknd 12625 11 a a DT cord-010119-t1x9gknd 12625 12 PSS PSS NNP cord-010119-t1x9gknd 12625 13 Alert Alert NNP cord-010119-t1x9gknd 12625 14 had have VBD cord-010119-t1x9gknd 12625 15 an an DT cord-010119-t1x9gknd 12625 16 active active JJ cord-010119-t1x9gknd 12625 17 sample sample NN cord-010119-t1x9gknd 12625 18 requiring require VBG cord-010119-t1x9gknd 12625 19 inactivation inactivation NN cord-010119-t1x9gknd 12625 20 . . . cord-010119-t1x9gknd 12626 1 Conclusion conclusion NN cord-010119-t1x9gknd 12626 2 : : : cord-010119-t1x9gknd 12626 3 Implementing implement VBG cord-010119-t1x9gknd 12626 4 an an DT cord-010119-t1x9gknd 12626 5 electronic electronic JJ cord-010119-t1x9gknd 12626 6 solution solution NN cord-010119-t1x9gknd 12626 7 that that WDT cord-010119-t1x9gknd 12626 8 requires require VBZ cord-010119-t1x9gknd 12626 9 documentation documentation NN cord-010119-t1x9gknd 12626 10 about about IN cord-010119-t1x9gknd 12626 11 PSS PSS NNP cord-010119-t1x9gknd 12626 12 eligibility eligibility NN cord-010119-t1x9gknd 12626 13 upon upon IN cord-010119-t1x9gknd 12626 14 return return NN cord-010119-t1x9gknd 12626 15 for for IN cord-010119-t1x9gknd 12626 16 surgery surgery NN cord-010119-t1x9gknd 12626 17 has have VBZ cord-010119-t1x9gknd 12626 18 resulted result VBN cord-010119-t1x9gknd 12626 19 in in IN cord-010119-t1x9gknd 12626 20 an an DT cord-010119-t1x9gknd 12626 21 estimated estimate VBN cord-010119-t1x9gknd 12626 22 3220 3220 CD cord-010119-t1x9gknd 12626 23 ( ( -LRB- cord-010119-t1x9gknd 12626 24 805x4 805x4 NN cord-010119-t1x9gknd 12626 25 ) ) -RRB- cord-010119-t1x9gknd 12626 26 PSS PSS NNP cord-010119-t1x9gknd 12626 27 Alerts alert VBZ cord-010119-t1x9gknd 12626 28 in in IN cord-010119-t1x9gknd 12626 29 the the DT cord-010119-t1x9gknd 12626 30 blood blood NN cord-010119-t1x9gknd 12626 31 bank bank NN cord-010119-t1x9gknd 12626 32 each each DT cord-010119-t1x9gknd 12626 33 year year NN cord-010119-t1x9gknd 12626 34 . . . cord-010119-t1x9gknd 12627 1 Of of IN cord-010119-t1x9gknd 12627 2 these these DT cord-010119-t1x9gknd 12627 3 Alerts alert NNS cord-010119-t1x9gknd 12627 4 , , , cord-010119-t1x9gknd 12627 5 it -PRON- PRP cord-010119-t1x9gknd 12627 6 is be VBZ cord-010119-t1x9gknd 12627 7 estimated estimate VBN cord-010119-t1x9gknd 12627 8 that that IN cord-010119-t1x9gknd 12627 9 approximately approximately RB cord-010119-t1x9gknd 12627 10 68 68 CD cord-010119-t1x9gknd 12627 11 patients patient NNS cord-010119-t1x9gknd 12627 12 ( ( -LRB- cord-010119-t1x9gknd 12627 13 17x4 17x4 CD cord-010119-t1x9gknd 12627 14 ) ) -RRB- cord-010119-t1x9gknd 12627 15 per per IN cord-010119-t1x9gknd 12627 16 year year NN cord-010119-t1x9gknd 12627 17 are be VBP cord-010119-t1x9gknd 12627 18 identified identify VBN cord-010119-t1x9gknd 12627 19 as as IN cord-010119-t1x9gknd 12627 20 no no RB cord-010119-t1x9gknd 12627 21 longer long RBR cord-010119-t1x9gknd 12627 22 eligible eligible JJ cord-010119-t1x9gknd 12627 23 for for IN cord-010119-t1x9gknd 12627 24 PSS PSS NNP cord-010119-t1x9gknd 12627 25 status status NN cord-010119-t1x9gknd 12627 26 . . . cord-010119-t1x9gknd 12628 1 Once once IN cord-010119-t1x9gknd 12628 2 this this DT cord-010119-t1x9gknd 12628 3 retrospective retrospective JJ cord-010119-t1x9gknd 12628 4 review review NN cord-010119-t1x9gknd 12628 5 was be VBD cord-010119-t1x9gknd 12628 6 performed perform VBN cord-010119-t1x9gknd 12628 7 , , , cord-010119-t1x9gknd 12628 8 it -PRON- PRP cord-010119-t1x9gknd 12628 9 was be VBD cord-010119-t1x9gknd 12628 10 shared share VBN cord-010119-t1x9gknd 12628 11 with with IN cord-010119-t1x9gknd 12628 12 the the DT cord-010119-t1x9gknd 12628 13 project project NN cord-010119-t1x9gknd 12628 14 stakeholders stakeholder NNS cord-010119-t1x9gknd 12628 15 to to TO cord-010119-t1x9gknd 12628 16 determine determine VB cord-010119-t1x9gknd 12628 17 if if IN cord-010119-t1x9gknd 12628 18 the the DT cord-010119-t1x9gknd 12628 19 electronic electronic JJ cord-010119-t1x9gknd 12628 20 questionnaire questionnaire NN cord-010119-t1x9gknd 12628 21 could could MD cord-010119-t1x9gknd 12628 22 be be VB cord-010119-t1x9gknd 12628 23 further further RB cord-010119-t1x9gknd 12628 24 tailored tailor VBN cord-010119-t1x9gknd 12628 25 to to IN cord-010119-t1x9gknd 12628 26 patient patient NN cord-010119-t1x9gknd 12628 27 's be VBZ cord-010119-t1x9gknd 12628 28 based base VBN cord-010119-t1x9gknd 12628 29 on on IN cord-010119-t1x9gknd 12628 30 age age NN cord-010119-t1x9gknd 12628 31 , , , cord-010119-t1x9gknd 12628 32 gender gender NN cord-010119-t1x9gknd 12628 33 , , , cord-010119-t1x9gknd 12628 34 and and CC cord-010119-t1x9gknd 12628 35 PSS PSS NNP cord-010119-t1x9gknd 12628 36 status status NN cord-010119-t1x9gknd 12628 37 . . . cord-010119-t1x9gknd 12629 1 While while IN cord-010119-t1x9gknd 12629 2 the the DT cord-010119-t1x9gknd 12629 3 benefit benefit NN cord-010119-t1x9gknd 12629 4 of of IN cord-010119-t1x9gknd 12629 5 having have VBG cord-010119-t1x9gknd 12629 6 fewer few JJR cord-010119-t1x9gknd 12629 7 false false JJ cord-010119-t1x9gknd 12629 8 positive positive JJ cord-010119-t1x9gknd 12629 9 PSS PSS NNP cord-010119-t1x9gknd 12629 10 alerts alert NNS cord-010119-t1x9gknd 12629 11 ( ( -LRB- cord-010119-t1x9gknd 12629 12 97.9 97.9 CD cord-010119-t1x9gknd 12629 13 % % NN cord-010119-t1x9gknd 12629 14 ) ) -RRB- cord-010119-t1x9gknd 12629 15 was be VBD cord-010119-t1x9gknd 12629 16 recognized recognize VBN cord-010119-t1x9gknd 12629 17 as as IN cord-010119-t1x9gknd 12629 18 an an DT cord-010119-t1x9gknd 12629 19 ideal ideal JJ cord-010119-t1x9gknd 12629 20 future future JJ cord-010119-t1x9gknd 12629 21 state state NN cord-010119-t1x9gknd 12629 22 , , , cord-010119-t1x9gknd 12629 23 it -PRON- PRP cord-010119-t1x9gknd 12629 24 was be VBD cord-010119-t1x9gknd 12629 25 not not RB cord-010119-t1x9gknd 12629 26 compatible compatible JJ cord-010119-t1x9gknd 12629 27 with with IN cord-010119-t1x9gknd 12629 28 the the DT cord-010119-t1x9gknd 12629 29 institution institution NN cord-010119-t1x9gknd 12629 30 's 's POS cord-010119-t1x9gknd 12629 31 current current JJ cord-010119-t1x9gknd 12629 32 IT IT NNP cord-010119-t1x9gknd 12629 33 project project NN cord-010119-t1x9gknd 12629 34 of of IN cord-010119-t1x9gknd 12629 35 implementing implement VBG cord-010119-t1x9gknd 12629 36 a a DT cord-010119-t1x9gknd 12629 37 new new JJ cord-010119-t1x9gknd 12629 38 Electronic Electronic NNP cord-010119-t1x9gknd 12629 39 Medical Medical NNP cord-010119-t1x9gknd 12629 40 Record Record NNP cord-010119-t1x9gknd 12629 41 ( ( -LRB- cord-010119-t1x9gknd 12629 42 EMR EMR NNP cord-010119-t1x9gknd 12629 43 ) ) -RRB- cord-010119-t1x9gknd 12629 44 system system NN cord-010119-t1x9gknd 12629 45 . . . cord-010119-t1x9gknd 12630 1 The the DT cord-010119-t1x9gknd 12630 2 safety safety NN cord-010119-t1x9gknd 12630 3 enhancement enhancement NN cord-010119-t1x9gknd 12630 4 provided provide VBN cord-010119-t1x9gknd 12630 5 by by IN cord-010119-t1x9gknd 12630 6 the the DT cord-010119-t1x9gknd 12630 7 current current JJ cord-010119-t1x9gknd 12630 8 electronic electronic JJ cord-010119-t1x9gknd 12630 9 fix fix NN cord-010119-t1x9gknd 12630 10 will will MD cord-010119-t1x9gknd 12630 11 remain remain VB cord-010119-t1x9gknd 12630 12 as as IN cord-010119-t1x9gknd 12630 13 is be VBZ cord-010119-t1x9gknd 12630 14 and and CC cord-010119-t1x9gknd 12630 15 the the DT cord-010119-t1x9gknd 12630 16 improvement improvement NN cord-010119-t1x9gknd 12630 17 suggestions suggestion NNS cord-010119-t1x9gknd 12630 18 were be VBD cord-010119-t1x9gknd 12630 19 shared share VBN cord-010119-t1x9gknd 12630 20 with with IN cord-010119-t1x9gknd 12630 21 the the DT cord-010119-t1x9gknd 12630 22 team team NN cord-010119-t1x9gknd 12630 23 creating create VBG cord-010119-t1x9gknd 12630 24 the the DT cord-010119-t1x9gknd 12630 25 parameters parameter NNS cord-010119-t1x9gknd 12630 26 for for IN cord-010119-t1x9gknd 12630 27 the the DT cord-010119-t1x9gknd 12630 28 new new JJ cord-010119-t1x9gknd 12630 29 EMR EMR NNP cord-010119-t1x9gknd 12630 30 with with IN cord-010119-t1x9gknd 12630 31 the the DT cord-010119-t1x9gknd 12630 32 intention intention NN cord-010119-t1x9gknd 12630 33 of of IN cord-010119-t1x9gknd 12630 34 targeting target VBG cord-010119-t1x9gknd 12630 35 only only RB cord-010119-t1x9gknd 12630 36 patients patient NNS cord-010119-t1x9gknd 12630 37 with with IN cord-010119-t1x9gknd 12630 38 an an DT cord-010119-t1x9gknd 12630 39 active active JJ cord-010119-t1x9gknd 12630 40 PSS pss NN cord-010119-t1x9gknd 12630 41 in in IN cord-010119-t1x9gknd 12630 42 the the DT cord-010119-t1x9gknd 12630 43 blood blood NN cord-010119-t1x9gknd 12630 44 bank bank NN cord-010119-t1x9gknd 12630 45 , , , cord-010119-t1x9gknd 12630 46 rather rather RB cord-010119-t1x9gknd 12630 47 than than IN cord-010119-t1x9gknd 12630 48 all all DT cord-010119-t1x9gknd 12630 49 surgical surgical JJ cord-010119-t1x9gknd 12630 50 patients patient NNS cord-010119-t1x9gknd 12630 51 . . . cord-010119-t1x9gknd 12631 1 Weill Weill NNP cord-010119-t1x9gknd 12631 2 Cornell Cornell NNP cord-010119-t1x9gknd 12631 3 Medicine Medicine NNP cord-010119-t1x9gknd 12631 4 , , , cord-010119-t1x9gknd 12631 5 7 7 CD cord-010119-t1x9gknd 12631 6 Columbia Columbia NNP cord-010119-t1x9gknd 12631 7 University University NNP cord-010119-t1x9gknd 12631 8 School School NNP cord-010119-t1x9gknd 12631 9 of of IN cord-010119-t1x9gknd 12631 10 Medicine Medicine NNP cord-010119-t1x9gknd 12631 11 Background Background NNP cord-010119-t1x9gknd 12631 12 / / SYM cord-010119-t1x9gknd 12631 13 Case Case NNP cord-010119-t1x9gknd 12631 14 Studies Studies NNPS cord-010119-t1x9gknd 12631 15 : : : cord-010119-t1x9gknd 12631 16 Blood blood NN cord-010119-t1x9gknd 12631 17 ordering ordering NN cord-010119-t1x9gknd 12631 18 is be VBZ cord-010119-t1x9gknd 12631 19 a a DT cord-010119-t1x9gknd 12631 20 complex complex JJ cord-010119-t1x9gknd 12631 21 , , , cord-010119-t1x9gknd 12631 22 high high JJ cord-010119-t1x9gknd 12631 23 - - HYPH cord-010119-t1x9gknd 12631 24 risk risk NN cord-010119-t1x9gknd 12631 25 process process NN cord-010119-t1x9gknd 12631 26 with with IN cord-010119-t1x9gknd 12631 27 multiple multiple JJ cord-010119-t1x9gknd 12631 28 steps step NNS cord-010119-t1x9gknd 12631 29 that that WDT cord-010119-t1x9gknd 12631 30 have have VBP cord-010119-t1x9gknd 12631 31 the the DT cord-010119-t1x9gknd 12631 32 potential potential NN cord-010119-t1x9gknd 12631 33 for for IN cord-010119-t1x9gknd 12631 34 errors error NNS cord-010119-t1x9gknd 12631 35 and and CC cord-010119-t1x9gknd 12631 36 delays delay NNS cord-010119-t1x9gknd 12631 37 . . . cord-010119-t1x9gknd 12632 1 Risks risk NNS cord-010119-t1x9gknd 12632 2 associated associate VBN cord-010119-t1x9gknd 12632 3 with with IN cord-010119-t1x9gknd 12632 4 this this DT cord-010119-t1x9gknd 12632 5 process process NN cord-010119-t1x9gknd 12632 6 , , , cord-010119-t1x9gknd 12632 7 from from IN cord-010119-t1x9gknd 12632 8 ordering order VBG cord-010119-t1x9gknd 12632 9 through through IN cord-010119-t1x9gknd 12632 10 pick pick NN cord-010119-t1x9gknd 12632 11 - - HYPH cord-010119-t1x9gknd 12632 12 up up NN cord-010119-t1x9gknd 12632 13 , , , cord-010119-t1x9gknd 12632 14 require require VB cord-010119-t1x9gknd 12632 15 evaluation evaluation NN cord-010119-t1x9gknd 12632 16 and and CC cord-010119-t1x9gknd 12632 17 strategies strategy NNS cord-010119-t1x9gknd 12632 18 for for IN cord-010119-t1x9gknd 12632 19 mitigation mitigation NN cord-010119-t1x9gknd 12632 20 . . . cord-010119-t1x9gknd 12633 1 Given give VBN cord-010119-t1x9gknd 12633 2 the the DT cord-010119-t1x9gknd 12633 3 complexity complexity NN cord-010119-t1x9gknd 12633 4 and and CC cord-010119-t1x9gknd 12633 5 high high JJ cord-010119-t1x9gknd 12633 6 - - HYPH cord-010119-t1x9gknd 12633 7 risk risk NN cord-010119-t1x9gknd 12633 8 nature nature NN cord-010119-t1x9gknd 12633 9 of of IN cord-010119-t1x9gknd 12633 10 blood blood NN cord-010119-t1x9gknd 12633 11 ordering order VBG cord-010119-t1x9gknd 12633 12 a a DT cord-010119-t1x9gknd 12633 13 proactive proactive JJ cord-010119-t1x9gknd 12633 14 risk risk NN cord-010119-t1x9gknd 12633 15 assessment assessment NN cord-010119-t1x9gknd 12633 16 ( ( -LRB- cord-010119-t1x9gknd 12633 17 PRA PRA NNP cord-010119-t1x9gknd 12633 18 ) ) -RRB- cord-010119-t1x9gknd 12633 19 for for IN cord-010119-t1x9gknd 12633 20 blood blood NN cord-010119-t1x9gknd 12633 21 product product NN cord-010119-t1x9gknd 12633 22 ordering order VBG cord-010119-t1x9gknd 12633 23 using use VBG cord-010119-t1x9gknd 12633 24 the the DT cord-010119-t1x9gknd 12633 25 FMEA FMEA NNP cord-010119-t1x9gknd 12633 26 methodology methodology NN cord-010119-t1x9gknd 12633 27 was be VBD cord-010119-t1x9gknd 12633 28 conducted conduct VBN cord-010119-t1x9gknd 12633 29 . . . cord-010119-t1x9gknd 12634 1 The the DT cord-010119-t1x9gknd 12634 2 goal goal NN cord-010119-t1x9gknd 12634 3 of of IN cord-010119-t1x9gknd 12634 4 the the DT cord-010119-t1x9gknd 12634 5 project project NN cord-010119-t1x9gknd 12634 6 was be VBD cord-010119-t1x9gknd 12634 7 to to TO cord-010119-t1x9gknd 12634 8 proactively proactively RB cord-010119-t1x9gknd 12634 9 assess assess VB cord-010119-t1x9gknd 12634 10 the the DT cord-010119-t1x9gknd 12634 11 effect effect NN cord-010119-t1x9gknd 12634 12 of of IN cord-010119-t1x9gknd 12634 13 a a DT cord-010119-t1x9gknd 12634 14 redesigned redesign VBN cord-010119-t1x9gknd 12634 15 electronic electronic JJ cord-010119-t1x9gknd 12634 16 order order NN cord-010119-t1x9gknd 12634 17 set set VBN cord-010119-t1x9gknd 12634 18 on on IN cord-010119-t1x9gknd 12634 19 the the DT cord-010119-t1x9gknd 12634 20 quality quality NN cord-010119-t1x9gknd 12634 21 and and CC cord-010119-t1x9gknd 12634 22 safety safety NN cord-010119-t1x9gknd 12634 23 of of IN cord-010119-t1x9gknd 12634 24 blood blood NN cord-010119-t1x9gknd 12634 25 ordering order VBG cord-010119-t1x9gknd 12634 26 Study Study NNP cord-010119-t1x9gknd 12634 27 Design Design NNP cord-010119-t1x9gknd 12634 28 / / SYM cord-010119-t1x9gknd 12634 29 Method method NN cord-010119-t1x9gknd 12634 30 : : : cord-010119-t1x9gknd 12634 31 To to TO cord-010119-t1x9gknd 12634 32 evaluate evaluate VB cord-010119-t1x9gknd 12634 33 the the DT cord-010119-t1x9gknd 12634 34 electronic electronic JJ cord-010119-t1x9gknd 12634 35 blood blood NN cord-010119-t1x9gknd 12634 36 ordering order VBG cord-010119-t1x9gknd 12634 37 redesign redesign NN cord-010119-t1x9gknd 12634 38 process process NN cord-010119-t1x9gknd 12634 39 , , , cord-010119-t1x9gknd 12634 40 a a DT cord-010119-t1x9gknd 12634 41 PRA PRA NNP cord-010119-t1x9gknd 12634 42 was be VBD cord-010119-t1x9gknd 12634 43 completed complete VBN cord-010119-t1x9gknd 12634 44 using use VBG cord-010119-t1x9gknd 12634 45 the the DT cord-010119-t1x9gknd 12634 46 FMEA FMEA NNP cord-010119-t1x9gknd 12634 47 methodology methodology NN cord-010119-t1x9gknd 12634 48 . . . cord-010119-t1x9gknd 12635 1 The the DT cord-010119-t1x9gknd 12635 2 team team NN cord-010119-t1x9gknd 12635 3 identified identify VBD cord-010119-t1x9gknd 12635 4 each each DT cord-010119-t1x9gknd 12635 5 step step NN cord-010119-t1x9gknd 12635 6 and and CC cord-010119-t1x9gknd 12635 7 sub sub NN cord-010119-t1x9gknd 12635 8 - - JJ cord-010119-t1x9gknd 12635 9 step step NN cord-010119-t1x9gknd 12635 10 of of IN cord-010119-t1x9gknd 12635 11 the the DT cord-010119-t1x9gknd 12635 12 electronic electronic JJ cord-010119-t1x9gknd 12635 13 blood blood NN cord-010119-t1x9gknd 12635 14 ordering ordering NN cord-010119-t1x9gknd 12635 15 process process NN cord-010119-t1x9gknd 12635 16 , , , cord-010119-t1x9gknd 12635 17 all all DT cord-010119-t1x9gknd 12635 18 failure failure NN cord-010119-t1x9gknd 12635 19 modes mode NNS cord-010119-t1x9gknd 12635 20 and and CC cord-010119-t1x9gknd 12635 21 causes cause NNS cord-010119-t1x9gknd 12635 22 , , , cord-010119-t1x9gknd 12635 23 and and CC cord-010119-t1x9gknd 12635 24 then then RB cord-010119-t1x9gknd 12635 25 scored score VBD cord-010119-t1x9gknd 12635 26 each each DT cord-010119-t1x9gknd 12635 27 by by IN cord-010119-t1x9gknd 12635 28 severity severity NN cord-010119-t1x9gknd 12635 29 occurrence occurrence NN cord-010119-t1x9gknd 12635 30 and and CC cord-010119-t1x9gknd 12635 31 detectability detectability NN cord-010119-t1x9gknd 12635 32 to to TO cord-010119-t1x9gknd 12635 33 determine determine VB cord-010119-t1x9gknd 12635 34 the the DT cord-010119-t1x9gknd 12635 35 Risk Risk NNP cord-010119-t1x9gknd 12635 36 Priority Priority NNP cord-010119-t1x9gknd 12635 37 Number Number NNP cord-010119-t1x9gknd 12635 38 ( ( -LRB- cord-010119-t1x9gknd 12635 39 RPN RPN NNP cord-010119-t1x9gknd 12635 40 ) ) -RRB- cord-010119-t1x9gknd 12635 41 . . . cord-010119-t1x9gknd 12636 1 All all DT cord-010119-t1x9gknd 12636 2 RPNs rpn NNS cord-010119-t1x9gknd 12636 3 with with IN cord-010119-t1x9gknd 12636 4 a a DT cord-010119-t1x9gknd 12636 5 score score NN cord-010119-t1x9gknd 12636 6 above above IN cord-010119-t1x9gknd 12636 7 the the DT cord-010119-t1x9gknd 12636 8 threshold threshold NN cord-010119-t1x9gknd 12636 9 were be VBD cord-010119-t1x9gknd 12636 10 reviewed review VBN cord-010119-t1x9gknd 12636 11 and and CC cord-010119-t1x9gknd 12636 12 rescored rescore VBN cord-010119-t1x9gknd 12636 13 based base VBN cord-010119-t1x9gknd 12636 14 on on IN cord-010119-t1x9gknd 12636 15 mitigation mitigation NN cord-010119-t1x9gknd 12636 16 strategies strategy NNS cord-010119-t1x9gknd 12636 17 designed design VBN cord-010119-t1x9gknd 12636 18 to to TO cord-010119-t1x9gknd 12636 19 address address VB cord-010119-t1x9gknd 12636 20 the the DT cord-010119-t1x9gknd 12636 21 failure failure NN cord-010119-t1x9gknd 12636 22 mode mode NN cord-010119-t1x9gknd 12636 23 . . . cord-010119-t1x9gknd 12637 1 Results/ Results/ . cord-010119-t1x9gknd 12638 1 Finding finding NN cord-010119-t1x9gknd 12638 2 : : : cord-010119-t1x9gknd 12639 1 The the DT cord-010119-t1x9gknd 12639 2 group group NN cord-010119-t1x9gknd 12639 3 scored score VBD cord-010119-t1x9gknd 12639 4 the the DT cord-010119-t1x9gknd 12639 5 identified identify VBN cord-010119-t1x9gknd 12639 6 failure failure NN cord-010119-t1x9gknd 12639 7 modes mode NNS cord-010119-t1x9gknd 12639 8 by by IN cord-010119-t1x9gknd 12639 9 categories category NNS cord-010119-t1x9gknd 12639 10 used use VBN cord-010119-t1x9gknd 12639 11 in in IN cord-010119-t1x9gknd 12639 12 root root NN cord-010119-t1x9gknd 12639 13 cause cause NN cord-010119-t1x9gknd 12639 14 analyses analysis NNS cord-010119-t1x9gknd 12639 15 . . . cord-010119-t1x9gknd 12640 1 The the DT cord-010119-t1x9gknd 12640 2 electronic electronic JJ cord-010119-t1x9gknd 12640 3 blood blood NN cord-010119-t1x9gknd 12640 4 order order NN cord-010119-t1x9gknd 12640 5 process process NN cord-010119-t1x9gknd 12640 6 has have VBZ cord-010119-t1x9gknd 12640 7 internal internal JJ cord-010119-t1x9gknd 12640 8 logic logic NN cord-010119-t1x9gknd 12640 9 and and CC cord-010119-t1x9gknd 12640 10 alerts alert NNS cord-010119-t1x9gknd 12640 11 that that WDT cord-010119-t1x9gknd 12640 12 improve improve VBP cord-010119-t1x9gknd 12640 13 communication communication NN cord-010119-t1x9gknd 12640 14 and and CC cord-010119-t1x9gknd 12640 15 reduce reduce VB cord-010119-t1x9gknd 12640 16 the the DT cord-010119-t1x9gknd 12640 17 risk risk NN cord-010119-t1x9gknd 12640 18 score score NN cord-010119-t1x9gknd 12640 19 . . . cord-010119-t1x9gknd 12641 1 Several several JJ cord-010119-t1x9gknd 12641 2 mitigation mitigation NN cord-010119-t1x9gknd 12641 3 strategies strategy NNS cord-010119-t1x9gknd 12641 4 that that WDT cord-010119-t1x9gknd 12641 5 will will MD cord-010119-t1x9gknd 12641 6 reduce reduce VB cord-010119-t1x9gknd 12641 7 the the DT cord-010119-t1x9gknd 12641 8 risk risk NN cord-010119-t1x9gknd 12641 9 of of IN cord-010119-t1x9gknd 12641 10 the the DT cord-010119-t1x9gknd 12641 11 identified identify VBN cord-010119-t1x9gknd 12641 12 failure failure NN cord-010119-t1x9gknd 12641 13 modes mode NNS cord-010119-t1x9gknd 12641 14 include include VBP cord-010119-t1x9gknd 12641 15 type type NN cord-010119-t1x9gknd 12641 16 and and CC cord-010119-t1x9gknd 12641 17 screen screen NN cord-010119-t1x9gknd 12641 18 status status NN cord-010119-t1x9gknd 12641 19 within within IN cord-010119-t1x9gknd 12641 20 the the DT cord-010119-t1x9gknd 12641 21 RBC RBC NNP cord-010119-t1x9gknd 12641 22 order order NN cord-010119-t1x9gknd 12641 23 , , , cord-010119-t1x9gknd 12641 24 streamlined streamlined JJ cord-010119-t1x9gknd 12641 25 alerts alert NNS cord-010119-t1x9gknd 12641 26 when when WRB cord-010119-t1x9gknd 12641 27 the the DT cord-010119-t1x9gknd 12641 28 order order NN cord-010119-t1x9gknd 12641 29 does do VBZ cord-010119-t1x9gknd 12641 30 not not RB cord-010119-t1x9gknd 12641 31 meet meet VB cord-010119-t1x9gknd 12641 32 the the DT cord-010119-t1x9gknd 12641 33 laboratory laboratory NN cord-010119-t1x9gknd 12641 34 threshold threshold NN cord-010119-t1x9gknd 12641 35 , , , cord-010119-t1x9gknd 12641 36 a a DT cord-010119-t1x9gknd 12641 37 nursing nursing NN cord-010119-t1x9gknd 12641 38 task task NN cord-010119-t1x9gknd 12641 39 list list NN cord-010119-t1x9gknd 12641 40 for for IN cord-010119-t1x9gknd 12641 41 transfusion transfusion NN cord-010119-t1x9gknd 12641 42 , , , cord-010119-t1x9gknd 12641 43 and and CC cord-010119-t1x9gknd 12641 44 a a DT cord-010119-t1x9gknd 12641 45 change change NN cord-010119-t1x9gknd 12641 46 to to IN cord-010119-t1x9gknd 12641 47 the the DT cord-010119-t1x9gknd 12641 48 pickup pickup NN cord-010119-t1x9gknd 12641 49 process process NN cord-010119-t1x9gknd 12641 50 that that WDT cord-010119-t1x9gknd 12641 51 is be VBZ cord-010119-t1x9gknd 12641 52 linked link VBN cord-010119-t1x9gknd 12641 53 to to IN cord-010119-t1x9gknd 12641 54 the the DT cord-010119-t1x9gknd 12641 55 product product NN cord-010119-t1x9gknd 12641 56 ready ready JJ cord-010119-t1x9gknd 12641 57 status status NN cord-010119-t1x9gknd 12641 58 in in IN cord-010119-t1x9gknd 12641 59 the the DT cord-010119-t1x9gknd 12641 60 laboratory laboratory NN cord-010119-t1x9gknd 12641 61 information information NN cord-010119-t1x9gknd 12641 62 system system NN cord-010119-t1x9gknd 12641 63 . . . cord-010119-t1x9gknd 12642 1 A a DT cord-010119-t1x9gknd 12642 2 transfusion transfusion NN cord-010119-t1x9gknd 12642 3 history history NN cord-010119-t1x9gknd 12642 4 will will MD cord-010119-t1x9gknd 12642 5 be be VB cord-010119-t1x9gknd 12642 6 available available JJ cord-010119-t1x9gknd 12642 7 to to IN cord-010119-t1x9gknd 12642 8 providers provider NNS cord-010119-t1x9gknd 12642 9 when when WRB cord-010119-t1x9gknd 12642 10 ordering order VBG cord-010119-t1x9gknd 12642 11 blood blood NN cord-010119-t1x9gknd 12642 12 products product NNS cord-010119-t1x9gknd 12642 13 to to TO cord-010119-t1x9gknd 12642 14 further further RB cord-010119-t1x9gknd 12642 15 reduce reduce VB cord-010119-t1x9gknd 12642 16 communication communication NN cord-010119-t1x9gknd 12642 17 risks risk NNS cord-010119-t1x9gknd 12642 18 . . . cord-010119-t1x9gknd 12643 1 Categories category NNS cord-010119-t1x9gknd 12643 2 for for IN cord-010119-t1x9gknd 12643 3 failure failure NN cord-010119-t1x9gknd 12643 4 modes mode NNS cord-010119-t1x9gknd 12643 5 included include VBD cord-010119-t1x9gknd 12643 6 Clinical Clinical NNP cord-010119-t1x9gknd 12643 7 , , , cord-010119-t1x9gknd 12643 8 Communication Communication NNP cord-010119-t1x9gknd 12643 9 , , , cord-010119-t1x9gknd 12643 10 Equipment Equipment NNP cord-010119-t1x9gknd 12643 11 People People NNPS cord-010119-t1x9gknd 12643 12 , , , cord-010119-t1x9gknd 12643 13 Process Process NNP cord-010119-t1x9gknd 12643 14 and and CC cord-010119-t1x9gknd 12643 15 System System NNP cord-010119-t1x9gknd 12643 16 . . . cord-010119-t1x9gknd 12644 1 The the DT cord-010119-t1x9gknd 12644 2 average average JJ cord-010119-t1x9gknd 12644 3 overall overall JJ cord-010119-t1x9gknd 12644 4 failure failure NN cord-010119-t1x9gknd 12644 5 mode mode NN cord-010119-t1x9gknd 12644 6 RPN RPN NNP cord-010119-t1x9gknd 12644 7 was be VBD cord-010119-t1x9gknd 12644 8 reduced reduce VBN cord-010119-t1x9gknd 12644 9 by by IN cord-010119-t1x9gknd 12644 10 29 29 CD cord-010119-t1x9gknd 12644 11 % % NN cord-010119-t1x9gknd 12644 12 with with IN cord-010119-t1x9gknd 12644 13 the the DT cord-010119-t1x9gknd 12644 14 communication communication NN cord-010119-t1x9gknd 12644 15 category category NN cord-010119-t1x9gknd 12644 16 average average JJ cord-010119-t1x9gknd 12644 17 RPN RPN NNP cord-010119-t1x9gknd 12644 18 having have VBG cord-010119-t1x9gknd 12644 19 the the DT cord-010119-t1x9gknd 12644 20 greatest great JJS cord-010119-t1x9gknd 12644 21 reduction reduction NN cord-010119-t1x9gknd 12644 22 of of IN cord-010119-t1x9gknd 12644 23 72 72 CD cord-010119-t1x9gknd 12644 24 % % NN cord-010119-t1x9gknd 12644 25 . . . cord-010119-t1x9gknd 12645 1 Conclusion conclusion NN cord-010119-t1x9gknd 12645 2 : : : cord-010119-t1x9gknd 12646 1 An an DT cord-010119-t1x9gknd 12646 2 FMEA FMEA NNP cord-010119-t1x9gknd 12646 3 of of IN cord-010119-t1x9gknd 12646 4 an an DT cord-010119-t1x9gknd 12646 5 electronic electronic JJ cord-010119-t1x9gknd 12646 6 blood blood NN cord-010119-t1x9gknd 12646 7 ordering ordering NN cord-010119-t1x9gknd 12646 8 process process NN cord-010119-t1x9gknd 12646 9 can can MD cord-010119-t1x9gknd 12646 10 proactively proactively RB cord-010119-t1x9gknd 12646 11 improve improve VB cord-010119-t1x9gknd 12646 12 quality quality NN cord-010119-t1x9gknd 12646 13 and and CC cord-010119-t1x9gknd 12646 14 patient patient JJ cord-010119-t1x9gknd 12646 15 safety safety NN cord-010119-t1x9gknd 12646 16 by by IN cord-010119-t1x9gknd 12646 17 preventing prevent VBG cord-010119-t1x9gknd 12646 18 transfusion transfusion NN cord-010119-t1x9gknd 12646 19 delays delay NNS cord-010119-t1x9gknd 12646 20 and and CC cord-010119-t1x9gknd 12646 21 errors error NNS cord-010119-t1x9gknd 12646 22 in in IN cord-010119-t1x9gknd 12646 23 blood blood NN cord-010119-t1x9gknd 12646 24 product product NN cord-010119-t1x9gknd 12646 25 administration administration NN cord-010119-t1x9gknd 12646 26 . . . cord-010119-t1x9gknd 12647 1 Accurate accurate JJ cord-010119-t1x9gknd 12647 2 and and CC cord-010119-t1x9gknd 12647 3 timely timely JJ cord-010119-t1x9gknd 12647 4 information information NN cord-010119-t1x9gknd 12647 5 in in IN cord-010119-t1x9gknd 12647 6 the the DT cord-010119-t1x9gknd 12647 7 blood blood NN cord-010119-t1x9gknd 12647 8 ordering ordering NN cord-010119-t1x9gknd 12647 9 process process NN cord-010119-t1x9gknd 12647 10 has have VBZ cord-010119-t1x9gknd 12647 11 the the DT cord-010119-t1x9gknd 12647 12 potential potential NN cord-010119-t1x9gknd 12647 13 to to TO cord-010119-t1x9gknd 12647 14 reduce reduce VB cord-010119-t1x9gknd 12647 15 risks risk NNS cord-010119-t1x9gknd 12647 16 associated associate VBN cord-010119-t1x9gknd 12647 17 with with IN cord-010119-t1x9gknd 12647 18 ordering ordering NN cord-010119-t1x9gknd 12647 19 , , , cord-010119-t1x9gknd 12647 20 preparing prepare VBG cord-010119-t1x9gknd 12647 21 and and CC cord-010119-t1x9gknd 12647 22 dispensing dispense VBG cord-010119-t1x9gknd 12647 23 blood blood NN cord-010119-t1x9gknd 12647 24 . . . cord-010119-t1x9gknd 12648 1 Reducing reduce VBG cord-010119-t1x9gknd 12648 2 Turn turn VB cord-010119-t1x9gknd 12648 3 Around around IN cord-010119-t1x9gknd 12648 4 Time time NN cord-010119-t1x9gknd 12648 5 for for IN cord-010119-t1x9gknd 12648 6 Type type NN cord-010119-t1x9gknd 12648 7 and and CC cord-010119-t1x9gknd 12648 8 Screens Screens NNPS cord-010119-t1x9gknd 12648 9 in in IN cord-010119-t1x9gknd 12648 10 the the DT cord-010119-t1x9gknd 12648 11 Blood Blood NNP cord-010119-t1x9gknd 12648 12 Bank Bank NNP cord-010119-t1x9gknd 12648 13 Kimberly Kimberly NNP cord-010119-t1x9gknd 12648 14 Ouellette Ouellette NNP cord-010119-t1x9gknd 12648 15 * * NFP cord-010119-t1x9gknd 12648 16 1 1 CD cord-010119-t1x9gknd 12648 17 , , , cord-010119-t1x9gknd 12648 18 Karen Karen NNP cord-010119-t1x9gknd 12648 19 King King NNP cord-010119-t1x9gknd 12648 20 1 1 CD cord-010119-t1x9gknd 12648 21 and and CC cord-010119-t1x9gknd 12648 22 Joseph Joseph NNP cord-010119-t1x9gknd 12648 23 Sweeney Sweeney NNP cord-010119-t1x9gknd 12649 1 2 2 LS cord-010119-t1x9gknd 12649 2 . . . cord-010119-t1x9gknd 12649 3 1 1 CD cord-010119-t1x9gknd 12649 4 Rhode Rhode NNP cord-010119-t1x9gknd 12649 5 Island Island NNP cord-010119-t1x9gknd 12649 6 Hospital Hospital NNP cord-010119-t1x9gknd 12649 7 , , , cord-010119-t1x9gknd 12649 8 2 2 CD cord-010119-t1x9gknd 12649 9 Lifespan Lifespan NNP cord-010119-t1x9gknd 12649 10 Academic Academic NNP cord-010119-t1x9gknd 12649 11 Medical Medical NNP cord-010119-t1x9gknd 12649 12 Center Center NNP cord-010119-t1x9gknd 12649 13 Background Background NNP cord-010119-t1x9gknd 12649 14 / / SYM cord-010119-t1x9gknd 12649 15 Case Case NNP cord-010119-t1x9gknd 12649 16 Studies Studies NNPS cord-010119-t1x9gknd 12649 17 : : : cord-010119-t1x9gknd 12649 18 Expeditious expeditious JJ cord-010119-t1x9gknd 12649 19 turn turn NN cord-010119-t1x9gknd 12649 20 - - HYPH cord-010119-t1x9gknd 12649 21 around around RP cord-010119-t1x9gknd 12649 22 times time NNS cord-010119-t1x9gknd 12649 23 ( ( -LRB- cord-010119-t1x9gknd 12649 24 TAT tat NN cord-010119-t1x9gknd 12649 25 ) ) -RRB- cord-010119-t1x9gknd 12649 26 in in IN cord-010119-t1x9gknd 12649 27 the the DT cord-010119-t1x9gknd 12649 28 blood blood NN cord-010119-t1x9gknd 12649 29 bank bank NN cord-010119-t1x9gknd 12649 30 are be VBP cord-010119-t1x9gknd 12649 31 critical critical JJ cord-010119-t1x9gknd 12649 32 to to TO cord-010119-t1x9gknd 12649 33 provide provide VB cord-010119-t1x9gknd 12649 34 fully fully RB cord-010119-t1x9gknd 12649 35 tested test VBN cord-010119-t1x9gknd 12649 36 and and CC cord-010119-t1x9gknd 12649 37 crossmatch crossmatch VB cord-010119-t1x9gknd 12649 38 compatible compatible JJ cord-010119-t1x9gknd 12649 39 blood blood NN cord-010119-t1x9gknd 12649 40 in in IN cord-010119-t1x9gknd 12649 41 a a DT cord-010119-t1x9gknd 12649 42 timely timely JJ cord-010119-t1x9gknd 12649 43 manner manner NN cord-010119-t1x9gknd 12649 44 . . . cord-010119-t1x9gknd 12650 1 The the DT cord-010119-t1x9gknd 12650 2 Blood Blood NNP cord-010119-t1x9gknd 12650 3 Bank Bank NNP cord-010119-t1x9gknd 12650 4 at at IN cord-010119-t1x9gknd 12650 5 Rhode Rhode NNP cord-010119-t1x9gknd 12650 6 Island Island NNP cord-010119-t1x9gknd 12650 7 Hospital Hospital NNP cord-010119-t1x9gknd 12650 8 , , , cord-010119-t1x9gknd 12650 9 a a DT cord-010119-t1x9gknd 12650 10 level level NN cord-010119-t1x9gknd 12650 11 1 1 CD cord-010119-t1x9gknd 12650 12 trauma trauma NN cord-010119-t1x9gknd 12650 13 center center NN cord-010119-t1x9gknd 12650 14 and and CC cord-010119-t1x9gknd 12650 15 teaching teaching NN cord-010119-t1x9gknd 12650 16 hospital hospital NN cord-010119-t1x9gknd 12650 17 associated associate VBN cord-010119-t1x9gknd 12650 18 with with IN cord-010119-t1x9gknd 12650 19 Brown Brown NNP cord-010119-t1x9gknd 12650 20 University University NNP cord-010119-t1x9gknd 12650 21 , , , cord-010119-t1x9gknd 12650 22 was be VBD cord-010119-t1x9gknd 12650 23 originally originally RB cord-010119-t1x9gknd 12650 24 designed design VBN cord-010119-t1x9gknd 12650 25 to to TO cord-010119-t1x9gknd 12650 26 accommodate accommodate VB cord-010119-t1x9gknd 12650 27 tube tube NN cord-010119-t1x9gknd 12650 28 testing testing NN cord-010119-t1x9gknd 12650 29 by by IN cord-010119-t1x9gknd 12650 30 all all DT cord-010119-t1x9gknd 12650 31 technologists technologist NNS cord-010119-t1x9gknd 12650 32 . . . cord-010119-t1x9gknd 12651 1 The the DT cord-010119-t1x9gknd 12651 2 original original JJ cord-010119-t1x9gknd 12651 3 setup setup NN cord-010119-t1x9gknd 12651 4 of of IN cord-010119-t1x9gknd 12651 5 the the DT cord-010119-t1x9gknd 12651 6 lab lab NN cord-010119-t1x9gknd 12651 7 was be VBD cord-010119-t1x9gknd 12651 8 split split VBN cord-010119-t1x9gknd 12651 9 into into IN cord-010119-t1x9gknd 12651 10 three three CD cord-010119-t1x9gknd 12651 11 sections section NNS cord-010119-t1x9gknd 12651 12 allowing allow VBG cord-010119-t1x9gknd 12651 13 for for IN cord-010119-t1x9gknd 12651 14 preparation preparation NN cord-010119-t1x9gknd 12651 15 and and CC cord-010119-t1x9gknd 12651 16 issuing issuing NN cord-010119-t1x9gknd 12651 17 of of IN cord-010119-t1x9gknd 12651 18 units unit NNS cord-010119-t1x9gknd 12651 19 in in IN cord-010119-t1x9gknd 12651 20 the the DT cord-010119-t1x9gknd 12651 21 first first JJ cord-010119-t1x9gknd 12651 22 section section NN cord-010119-t1x9gknd 12651 23 , , , cord-010119-t1x9gknd 12651 24 bench bench NN cord-010119-t1x9gknd 12651 25 testing testing NN cord-010119-t1x9gknd 12651 26 in in IN cord-010119-t1x9gknd 12651 27 the the DT cord-010119-t1x9gknd 12651 28 second second JJ cord-010119-t1x9gknd 12651 29 , , , cord-010119-t1x9gknd 12651 30 and and CC cord-010119-t1x9gknd 12651 31 the the DT cord-010119-t1x9gknd 12651 32 receipt receipt NN cord-010119-t1x9gknd 12651 33 of of IN cord-010119-t1x9gknd 12651 34 components component NNS cord-010119-t1x9gknd 12651 35 in in IN cord-010119-t1x9gknd 12651 36 the the DT cord-010119-t1x9gknd 12651 37 third third NN cord-010119-t1x9gknd 12651 38 . . . cord-010119-t1x9gknd 12652 1 As as IN cord-010119-t1x9gknd 12652 2 technology technology NN cord-010119-t1x9gknd 12652 3 changed change VBD cord-010119-t1x9gknd 12652 4 , , , cord-010119-t1x9gknd 12652 5 the the DT cord-010119-t1x9gknd 12652 6 blood blood NN cord-010119-t1x9gknd 12652 7 bank bank NN cord-010119-t1x9gknd 12652 8 adopted adopt VBD cord-010119-t1x9gknd 12652 9 first first RB cord-010119-t1x9gknd 12652 10 the the DT cord-010119-t1x9gknd 12652 11 manual manual NNP cord-010119-t1x9gknd 12652 12 gel gel NN cord-010119-t1x9gknd 12652 13 station station NN cord-010119-t1x9gknd 12652 14 and and CC cord-010119-t1x9gknd 12652 15 then then RB cord-010119-t1x9gknd 12652 16 the the DT cord-010119-t1x9gknd 12652 17 automated automate VBN cord-010119-t1x9gknd 12652 18 gel gel NN cord-010119-t1x9gknd 12652 19 system system NN cord-010119-t1x9gknd 12652 20 ( ( -LRB- cord-010119-t1x9gknd 12652 21 Ortho Ortho NNP cord-010119-t1x9gknd 12652 22 ProvueV ProvueV NNP cord-010119-t1x9gknd 12652 23 R R NNP cord-010119-t1x9gknd 12652 24 ) ) -RRB- cord-010119-t1x9gknd 12652 25 but but CC cord-010119-t1x9gknd 12652 26 did do VBD cord-010119-t1x9gknd 12652 27 not not RB cord-010119-t1x9gknd 12652 28 adapt adapt VB cord-010119-t1x9gknd 12652 29 the the DT cord-010119-t1x9gknd 12652 30 space space NN cord-010119-t1x9gknd 12652 31 . . . cord-010119-t1x9gknd 12653 1 The the DT cord-010119-t1x9gknd 12653 2 second second JJ cord-010119-t1x9gknd 12653 3 section section NN cord-010119-t1x9gknd 12653 4 of of IN cord-010119-t1x9gknd 12653 5 the the DT cord-010119-t1x9gknd 12653 6 blood blood NN cord-010119-t1x9gknd 12653 7 bank bank NN cord-010119-t1x9gknd 12653 8 contained contain VBD cord-010119-t1x9gknd 12653 9 the the DT cord-010119-t1x9gknd 12653 10 manual manual NN cord-010119-t1x9gknd 12653 11 and and CC cord-010119-t1x9gknd 12653 12 subsequently subsequently RB cord-010119-t1x9gknd 12653 13 automated automate VBD cord-010119-t1x9gknd 12653 14 gel gel NN cord-010119-t1x9gknd 12653 15 stations station NNS cord-010119-t1x9gknd 12653 16 with with IN cord-010119-t1x9gknd 12653 17 no no DT cord-010119-t1x9gknd 12653 18 other other JJ cord-010119-t1x9gknd 12653 19 changes change NNS cord-010119-t1x9gknd 12653 20 . . . cord-010119-t1x9gknd 12654 1 The the DT cord-010119-t1x9gknd 12654 2 process process NN cord-010119-t1x9gknd 12654 3 of of IN cord-010119-t1x9gknd 12654 4 sample sample NN cord-010119-t1x9gknd 12654 5 receipt receipt NN cord-010119-t1x9gknd 12654 6 through through IN cord-010119-t1x9gknd 12654 7 completion completion NN cord-010119-t1x9gknd 12654 8 of of IN cord-010119-t1x9gknd 12654 9 testing testing NN cord-010119-t1x9gknd 12654 10 and and CC cord-010119-t1x9gknd 12654 11 issuing issuing NN cord-010119-t1x9gknd 12654 12 of of IN cord-010119-t1x9gknd 12654 13 units unit NNS cord-010119-t1x9gknd 12654 14 remained remain VBD cord-010119-t1x9gknd 12654 15 segmented segmented JJ cord-010119-t1x9gknd 12654 16 and and CC cord-010119-t1x9gknd 12654 17 inefficient inefficient JJ cord-010119-t1x9gknd 12654 18 . . . cord-010119-t1x9gknd 12655 1 The the DT cord-010119-t1x9gknd 12655 2 average average JJ cord-010119-t1x9gknd 12655 3 TAT tat NN cord-010119-t1x9gknd 12655 4 for for IN cord-010119-t1x9gknd 12655 5 type type NN cord-010119-t1x9gknd 12655 6 and and CC cord-010119-t1x9gknd 12655 7 screens screen NNS cord-010119-t1x9gknd 12655 8 was be VBD cord-010119-t1x9gknd 12655 9 80 80 CD cord-010119-t1x9gknd 12655 10 6 6 CD cord-010119-t1x9gknd 12655 11 32 32 CD cord-010119-t1x9gknd 12655 12 minutes minute NNS cord-010119-t1x9gknd 12655 13 . . . cord-010119-t1x9gknd 12656 1 Study Study NNP cord-010119-t1x9gknd 12656 2 Design Design NNP cord-010119-t1x9gknd 12656 3 / / SYM cord-010119-t1x9gknd 12656 4 Method method NN cord-010119-t1x9gknd 12656 5 : : : cord-010119-t1x9gknd 12657 1 The the DT cord-010119-t1x9gknd 12657 2 Blood Blood NNP cord-010119-t1x9gknd 12657 3 Bank Bank NNP cord-010119-t1x9gknd 12657 4 design design NN cord-010119-t1x9gknd 12657 5 was be VBD cord-010119-t1x9gknd 12657 6 remodeled remodel VBN cord-010119-t1x9gknd 12657 7 to to TO cord-010119-t1x9gknd 12657 8 make make VB cord-010119-t1x9gknd 12657 9 for for IN cord-010119-t1x9gknd 12657 10 a a DT cord-010119-t1x9gknd 12657 11 more more RBR cord-010119-t1x9gknd 12657 12 open open JJ cord-010119-t1x9gknd 12657 13 concept concept NN cord-010119-t1x9gknd 12657 14 to to TO cord-010119-t1x9gknd 12657 15 allow allow VB cord-010119-t1x9gknd 12657 16 for for IN cord-010119-t1x9gknd 12657 17 collaboration collaboration NN cord-010119-t1x9gknd 12657 18 amongst amongst IN cord-010119-t1x9gknd 12657 19 technologists technologist NNS cord-010119-t1x9gknd 12657 20 as as RB cord-010119-t1x9gknd 12657 21 well well RB cord-010119-t1x9gknd 12657 22 as as IN cord-010119-t1x9gknd 12657 23 the the DT cord-010119-t1x9gknd 12657 24 best good JJS cord-010119-t1x9gknd 12657 25 use use NN cord-010119-t1x9gknd 12657 26 of of IN cord-010119-t1x9gknd 12657 27 space space NN cord-010119-t1x9gknd 12657 28 and and CC cord-010119-t1x9gknd 12657 29 technology technology NN cord-010119-t1x9gknd 12657 30 . . . cord-010119-t1x9gknd 12658 1 The the DT cord-010119-t1x9gknd 12658 2 first first JJ cord-010119-t1x9gknd 12658 3 section section NN cord-010119-t1x9gknd 12658 4 of of IN cord-010119-t1x9gknd 12658 5 tables table NNS cord-010119-t1x9gknd 12658 6 were be VBD cord-010119-t1x9gknd 12658 7 removed remove VBN cord-010119-t1x9gknd 12658 8 and and CC cord-010119-t1x9gknd 12658 9 replaced replace VBN cord-010119-t1x9gknd 12658 10 with with IN cord-010119-t1x9gknd 12658 11 a a DT cord-010119-t1x9gknd 12658 12 center center NN cord-010119-t1x9gknd 12658 13 console console NN cord-010119-t1x9gknd 12658 14 to to TO cord-010119-t1x9gknd 12658 15 allow allow VB cord-010119-t1x9gknd 12658 16 for for IN cord-010119-t1x9gknd 12658 17 movement movement NN cord-010119-t1x9gknd 12658 18 about about IN cord-010119-t1x9gknd 12658 19 the the DT cord-010119-t1x9gknd 12658 20 entire entire JJ cord-010119-t1x9gknd 12658 21 front front NN cord-010119-t1x9gknd 12658 22 of of IN cord-010119-t1x9gknd 12658 23 the the DT cord-010119-t1x9gknd 12658 24 laboratory laboratory NN cord-010119-t1x9gknd 12658 25 . . . cord-010119-t1x9gknd 12659 1 A a DT cord-010119-t1x9gknd 12659 2 wall wall NN cord-010119-t1x9gknd 12659 3 was be VBD cord-010119-t1x9gknd 12659 4 constructed construct VBN cord-010119-t1x9gknd 12659 5 to to TO cord-010119-t1x9gknd 12659 6 separate separate VB cord-010119-t1x9gknd 12659 7 the the DT cord-010119-t1x9gknd 12659 8 main main JJ cord-010119-t1x9gknd 12659 9 work work NN cord-010119-t1x9gknd 12659 10 flow flow NN cord-010119-t1x9gknd 12659 11 , , , cord-010119-t1x9gknd 12659 12 automated automate VBN cord-010119-t1x9gknd 12659 13 gel gel NN cord-010119-t1x9gknd 12659 14 testing testing NN cord-010119-t1x9gknd 12659 15 and and CC cord-010119-t1x9gknd 12659 16 issuing issue VBG cord-010119-t1x9gknd 12659 17 units unit NNS cord-010119-t1x9gknd 12659 18 , , , cord-010119-t1x9gknd 12659 19 from from IN cord-010119-t1x9gknd 12659 20 the the DT cord-010119-t1x9gknd 12659 21 area area NN cord-010119-t1x9gknd 12659 22 for for IN cord-010119-t1x9gknd 12659 23 complicated complicated JJ cord-010119-t1x9gknd 12659 24 workups workup NNS cord-010119-t1x9gknd 12659 25 and and CC cord-010119-t1x9gknd 12659 26 inventory inventory NN cord-010119-t1x9gknd 12659 27 receipt receipt NN cord-010119-t1x9gknd 12659 28 . . . cord-010119-t1x9gknd 12660 1 The the DT cord-010119-t1x9gknd 12660 2 third third JJ cord-010119-t1x9gknd 12660 3 section section NN cord-010119-t1x9gknd 12660 4 remained remain VBD cord-010119-t1x9gknd 12660 5 , , , cord-010119-t1x9gknd 12660 6 but but CC cord-010119-t1x9gknd 12660 7 was be VBD cord-010119-t1x9gknd 12660 8 repurposed repurpose VBN cord-010119-t1x9gknd 12660 9 for for IN cord-010119-t1x9gknd 12660 10 teaching teach VBG cord-010119-t1x9gknd 12660 11 medical medical JJ cord-010119-t1x9gknd 12660 12 technology technology NN cord-010119-t1x9gknd 12660 13 students student NNS cord-010119-t1x9gknd 12660 14 and and CC cord-010119-t1x9gknd 12660 15 residents resident NNS cord-010119-t1x9gknd 12660 16 . . . cord-010119-t1x9gknd 12661 1 In in IN cord-010119-t1x9gknd 12661 2 addition addition NN cord-010119-t1x9gknd 12661 3 to to IN cord-010119-t1x9gknd 12661 4 the the DT cord-010119-t1x9gknd 12661 5 remodel remodel NN cord-010119-t1x9gknd 12661 6 , , , cord-010119-t1x9gknd 12661 7 the the DT cord-010119-t1x9gknd 12661 8 blood blood NN cord-010119-t1x9gknd 12661 9 bank bank NN cord-010119-t1x9gknd 12661 10 retired retire VBD cord-010119-t1x9gknd 12661 11 the the DT cord-010119-t1x9gknd 12661 12 Ortho Ortho NNP cord-010119-t1x9gknd 12661 13 ProvueV ProvueV NNS cord-010119-t1x9gknd 12661 14 R r NN cord-010119-t1x9gknd 12661 15 for for IN cord-010119-t1x9gknd 12661 16 the the DT cord-010119-t1x9gknd 12661 17 Ortho Ortho NNP cord-010119-t1x9gknd 12661 18 VisionV visionv NN cord-010119-t1x9gknd 12661 19 R R NNP cord-010119-t1x9gknd 12661 20 , , , cord-010119-t1x9gknd 12661 21 which which WDT cord-010119-t1x9gknd 12661 22 is be VBZ cord-010119-t1x9gknd 12661 23 considered consider VBN cord-010119-t1x9gknd 12661 24 a a DT cord-010119-t1x9gknd 12661 25 true true JJ cord-010119-t1x9gknd 12661 26 continuous continuous JJ cord-010119-t1x9gknd 12661 27 feed feed NN cord-010119-t1x9gknd 12661 28 machine machine NN cord-010119-t1x9gknd 12661 29 . . . cord-010119-t1x9gknd 12662 1 Although although IN cord-010119-t1x9gknd 12662 2 the the DT cord-010119-t1x9gknd 12662 3 inter inter JJ cord-010119-t1x9gknd 12662 4 - - NN cord-010119-t1x9gknd 12662 5 device device NN cord-010119-t1x9gknd 12662 6 TAT tat NN cord-010119-t1x9gknd 12662 7 is be VBZ cord-010119-t1x9gknd 12662 8 not not RB cord-010119-t1x9gknd 12662 9 significantly significantly RB cord-010119-t1x9gknd 12662 10 different different JJ cord-010119-t1x9gknd 12662 11 ( ( -LRB- cord-010119-t1x9gknd 12662 12 30 30 CD cord-010119-t1x9gknd 12662 13 minutes minute NNS cord-010119-t1x9gknd 12662 14 for for IN cord-010119-t1x9gknd 12662 15 the the DT cord-010119-t1x9gknd 12662 16 ProvueV ProvueV NNS cord-010119-t1x9gknd 12662 17 R r NN cord-010119-t1x9gknd 12662 18 and and CC cord-010119-t1x9gknd 12662 19 28 28 CD cord-010119-t1x9gknd 12662 20 for for IN cord-010119-t1x9gknd 12662 21 the the DT cord-010119-t1x9gknd 12662 22 VisionV visionv NN cord-010119-t1x9gknd 12662 23 R r NN cord-010119-t1x9gknd 12662 24 ) ) -RRB- cord-010119-t1x9gknd 12663 1 the the DT cord-010119-t1x9gknd 12663 2 VisionV VisionV NNP cord-010119-t1x9gknd 12663 3 R R NNP cord-010119-t1x9gknd 12663 4 is be VBZ cord-010119-t1x9gknd 12663 5 built build VBN cord-010119-t1x9gknd 12663 6 with with IN cord-010119-t1x9gknd 12663 7 a a DT cord-010119-t1x9gknd 12663 8 scheduler scheduler NN cord-010119-t1x9gknd 12663 9 that that WDT cord-010119-t1x9gknd 12663 10 effectively effectively RB cord-010119-t1x9gknd 12663 11 handles handle VBZ cord-010119-t1x9gknd 12663 12 the the DT cord-010119-t1x9gknd 12663 13 system system NN cord-010119-t1x9gknd 12663 14 and and CC cord-010119-t1x9gknd 12663 15 processes process VBZ cord-010119-t1x9gknd 12663 16 samples sample NNS cord-010119-t1x9gknd 12663 17 efficiently efficiently RB cord-010119-t1x9gknd 12663 18 . . . cord-010119-t1x9gknd 12664 1 The the DT cord-010119-t1x9gknd 12664 2 VisionV visionv NN cord-010119-t1x9gknd 12664 3 R r NN cord-010119-t1x9gknd 12664 4 is be VBZ cord-010119-t1x9gknd 12664 5 also also RB cord-010119-t1x9gknd 12664 6 equipped equip VBN cord-010119-t1x9gknd 12664 7 with with IN cord-010119-t1x9gknd 12664 8 two two CD cord-010119-t1x9gknd 12664 9 centrifuges centrifuge NNS cord-010119-t1x9gknd 12664 10 to to TO cord-010119-t1x9gknd 12664 11 process process VB cord-010119-t1x9gknd 12664 12 samples sample NNS cord-010119-t1x9gknd 12664 13 , , , cord-010119-t1x9gknd 12664 14 which which WDT cord-010119-t1x9gknd 12664 15 further further RB cord-010119-t1x9gknd 12664 16 reduces reduce VBZ cord-010119-t1x9gknd 12664 17 TAT tat NN cord-010119-t1x9gknd 12664 18 when when WRB cord-010119-t1x9gknd 12664 19 multiple multiple JJ cord-010119-t1x9gknd 12664 20 samples sample NNS cord-010119-t1x9gknd 12664 21 are be VBP cord-010119-t1x9gknd 12664 22 onboard onboard JJ cord-010119-t1x9gknd 12664 23 . . . cord-010119-t1x9gknd 12665 1 A a DT cord-010119-t1x9gknd 12665 2 bi bi JJ cord-010119-t1x9gknd 12665 3 - - JJ cord-010119-t1x9gknd 12665 4 directional directional JJ cord-010119-t1x9gknd 12665 5 interface interface NN cord-010119-t1x9gknd 12665 6 was be VBD cord-010119-t1x9gknd 12665 7 designed design VBN cord-010119-t1x9gknd 12665 8 to to TO cord-010119-t1x9gknd 12665 9 allow allow VB cord-010119-t1x9gknd 12665 10 for for IN cord-010119-t1x9gknd 12665 11 test test NN cord-010119-t1x9gknd 12665 12 orders order NNS cord-010119-t1x9gknd 12665 13 ( ( -LRB- cord-010119-t1x9gknd 12665 14 type type NN cord-010119-t1x9gknd 12665 15 and and CC cord-010119-t1x9gknd 12665 16 screens screen NNS cord-010119-t1x9gknd 12665 17 ) ) -RRB- cord-010119-t1x9gknd 12665 18 to to TO cord-010119-t1x9gknd 12665 19 go go VB cord-010119-t1x9gknd 12665 20 to to IN cord-010119-t1x9gknd 12665 21 the the DT cord-010119-t1x9gknd 12665 22 VisionV visionv NN cord-010119-t1x9gknd 12665 23 R r NN cord-010119-t1x9gknd 12665 24 and and CC cord-010119-t1x9gknd 12665 25 test test NN cord-010119-t1x9gknd 12665 26 results result NNS cord-010119-t1x9gknd 12665 27 to to TO cord-010119-t1x9gknd 12665 28 go go VB cord-010119-t1x9gknd 12665 29 directly directly RB cord-010119-t1x9gknd 12665 30 from from IN cord-010119-t1x9gknd 12665 31 the the DT cord-010119-t1x9gknd 12665 32 VisionV visionv NN cord-010119-t1x9gknd 12665 33 R r NN cord-010119-t1x9gknd 12665 34 to to IN cord-010119-t1x9gknd 12665 35 the the DT cord-010119-t1x9gknd 12665 36 LIS LIS NNP cord-010119-t1x9gknd 12665 37 without without IN cord-010119-t1x9gknd 12665 38 the the DT cord-010119-t1x9gknd 12665 39 need need NN cord-010119-t1x9gknd 12665 40 to to TO cord-010119-t1x9gknd 12665 41 manually manually RB cord-010119-t1x9gknd 12665 42 order order VB cord-010119-t1x9gknd 12665 43 the the DT cord-010119-t1x9gknd 12665 44 tests test NNS cord-010119-t1x9gknd 12665 45 or or CC cord-010119-t1x9gknd 12665 46 transmit transmit VB cord-010119-t1x9gknd 12665 47 the the DT cord-010119-t1x9gknd 12665 48 results result NNS cord-010119-t1x9gknd 12665 49 . . . cord-010119-t1x9gknd 12666 1 Data datum NNS cord-010119-t1x9gknd 12666 2 on on IN cord-010119-t1x9gknd 12666 3 TAT TAT NNP cord-010119-t1x9gknd 12666 4 were be VBD cord-010119-t1x9gknd 12666 5 collected collect VBN cord-010119-t1x9gknd 12666 6 and and CC cord-010119-t1x9gknd 12666 7 analyzed analyze VBN cord-010119-t1x9gknd 12666 8 using use VBG cord-010119-t1x9gknd 12666 9 independent independent JJ cord-010119-t1x9gknd 12666 10 t t NN cord-010119-t1x9gknd 12666 11 tests test NNS cord-010119-t1x9gknd 12666 12 and and CC cord-010119-t1x9gknd 12666 13 chi chi NNP cord-010119-t1x9gknd 12666 14 square square NNP cord-010119-t1x9gknd 12666 15 . . . cord-010119-t1x9gknd 12667 1 Results/ Results/ . cord-010119-t1x9gknd 12668 1 Finding finding NN cord-010119-t1x9gknd 12668 2 : : : cord-010119-t1x9gknd 12669 1 The the DT cord-010119-t1x9gknd 12670 1 mean mean VB cord-010119-t1x9gknd 12670 2 TAT TAT NNP cord-010119-t1x9gknd 12670 3 pre pre JJ cord-010119-t1x9gknd 12670 4 - - JJ cord-010119-t1x9gknd 12670 5 and and CC cord-010119-t1x9gknd 12670 6 post post JJ cord-010119-t1x9gknd 12670 7 - - NN cord-010119-t1x9gknd 12670 8 reconfiguration reconfiguration NN cord-010119-t1x9gknd 12670 9 and and CC cord-010119-t1x9gknd 12670 10 implementation implementation NN cord-010119-t1x9gknd 12670 11 of of IN cord-010119-t1x9gknd 12670 12 the the DT cord-010119-t1x9gknd 12670 13 Ortho Ortho NNP cord-010119-t1x9gknd 12670 14 VisionV visionv NN cord-010119-t1x9gknd 12670 15 R r NN cord-010119-t1x9gknd 12670 16 and and CC cord-010119-t1x9gknd 12670 17 a a DT cord-010119-t1x9gknd 12670 18 fraction fraction NN cord-010119-t1x9gknd 12670 19 of of IN cord-010119-t1x9gknd 12670 20 samples sample NNS cord-010119-t1x9gknd 12670 21 with with IN cord-010119-t1x9gknd 12670 22 TAT TAT NNP cord-010119-t1x9gknd 12670 23 over over IN cord-010119-t1x9gknd 12670 24 90 90 CD cord-010119-t1x9gknd 12670 25 minutes minute NNS cord-010119-t1x9gknd 12670 26 are be VBP cord-010119-t1x9gknd 12670 27 shown show VBN cord-010119-t1x9gknd 12670 28 in in IN cord-010119-t1x9gknd 12670 29 the the DT cord-010119-t1x9gknd 12670 30 table table NN cord-010119-t1x9gknd 12670 31 . . . cord-010119-t1x9gknd 12671 1 The the DT cord-010119-t1x9gknd 12671 2 results result NNS cord-010119-t1x9gknd 12671 3 show show VBP cord-010119-t1x9gknd 12671 4 a a DT cord-010119-t1x9gknd 12671 5 reduction reduction NN cord-010119-t1x9gknd 12671 6 in in IN cord-010119-t1x9gknd 12671 7 TAT tat NN cord-010119-t1x9gknd 12671 8 by by IN cord-010119-t1x9gknd 12671 9 14 14 CD cord-010119-t1x9gknd 12671 10 minutes minute NNS cord-010119-t1x9gknd 12671 11 with with IN cord-010119-t1x9gknd 12671 12 a a DT cord-010119-t1x9gknd 12671 13 20 20 CD cord-010119-t1x9gknd 12671 14 % % NN cord-010119-t1x9gknd 12671 15 reduction reduction NN cord-010119-t1x9gknd 12671 16 of of IN cord-010119-t1x9gknd 12671 17 TAT tat NN cord-010119-t1x9gknd 12671 18 greater great JJR cord-010119-t1x9gknd 12671 19 than than IN cord-010119-t1x9gknd 12671 20 90 90 CD cord-010119-t1x9gknd 12671 21 minutes minute NNS cord-010119-t1x9gknd 12671 22 . . . cord-010119-t1x9gknd 12672 1 Conclusion conclusion NN cord-010119-t1x9gknd 12672 2 : : : cord-010119-t1x9gknd 12673 1 A a DT cord-010119-t1x9gknd 12673 2 combination combination NN cord-010119-t1x9gknd 12673 3 of of IN cord-010119-t1x9gknd 12673 4 new new JJ cord-010119-t1x9gknd 12673 5 technology technology NN cord-010119-t1x9gknd 12673 6 and and CC cord-010119-t1x9gknd 12673 7 space space NN cord-010119-t1x9gknd 12673 8 remodeling remodeling NN cord-010119-t1x9gknd 12673 9 can can MD cord-010119-t1x9gknd 12673 10 lead lead VB cord-010119-t1x9gknd 12673 11 to to IN cord-010119-t1x9gknd 12673 12 a a DT cord-010119-t1x9gknd 12673 13 significant significant JJ cord-010119-t1x9gknd 12673 14 reduction reduction NN cord-010119-t1x9gknd 12673 15 of of IN cord-010119-t1x9gknd 12673 16 TAT tat NN cord-010119-t1x9gknd 12673 17 of of IN cord-010119-t1x9gknd 12673 18 testing testing NN cord-010119-t1x9gknd 12673 19 in in IN cord-010119-t1x9gknd 12673 20 the the DT cord-010119-t1x9gknd 12673 21 blood blood NN cord-010119-t1x9gknd 12673 22 bank bank NN cord-010119-t1x9gknd 12673 23 . . . cord-010119-t1x9gknd 12674 1 Caleb Caleb NNP cord-010119-t1x9gknd 12674 2 Wei Wei NNP cord-010119-t1x9gknd 12674 3 - - HYPH cord-010119-t1x9gknd 12674 4 Shin Shin NNP cord-010119-t1x9gknd 12674 5 Cheng Cheng NNP cord-010119-t1x9gknd 12675 1 * * NFP cord-010119-t1x9gknd 12675 2 1,2 1,2 CD cord-010119-t1x9gknd 12675 3 , , , cord-010119-t1x9gknd 12675 4 Lorna Lorna NNP cord-010119-t1x9gknd 12675 5 Orengo Orengo NNP cord-010119-t1x9gknd 12675 6 3 3 CD cord-010119-t1x9gknd 12675 7 , , , cord-010119-t1x9gknd 12675 8 Monique Monique NNP cord-010119-t1x9gknd 12675 9 Scott Scott NNP cord-010119-t1x9gknd 12675 10 3 3 CD cord-010119-t1x9gknd 12675 11 and and CC cord-010119-t1x9gknd 12675 12 Christopher Christopher NNP cord-010119-t1x9gknd 12675 13 A A NNP cord-010119-t1x9gknd 12675 14 Tormey Tormey NNP cord-010119-t1x9gknd 12675 15 1,2,3 1,2,3 CD cord-010119-t1x9gknd 12675 16 . . . cord-010119-t1x9gknd 12676 1 1 1 CD cord-010119-t1x9gknd 12676 2 Yale Yale NNP cord-010119-t1x9gknd 12676 3 University University NNP cord-010119-t1x9gknd 12676 4 School School NNP cord-010119-t1x9gknd 12676 5 of of IN cord-010119-t1x9gknd 12676 6 Medicine Medicine NNP cord-010119-t1x9gknd 12676 7 , , , cord-010119-t1x9gknd 12676 8 2 2 CD cord-010119-t1x9gknd 12676 9 Yale Yale NNP cord-010119-t1x9gknd 12676 10 - - HYPH cord-010119-t1x9gknd 12676 11 New New NNP cord-010119-t1x9gknd 12676 12 Haven Haven NNP cord-010119-t1x9gknd 12676 13 Hospital Hospital NNP cord-010119-t1x9gknd 12676 14 , , , cord-010119-t1x9gknd 12676 15 3 3 CD cord-010119-t1x9gknd 12676 16 VA VA NNP cord-010119-t1x9gknd 12676 17 Connecticut Connecticut NNP cord-010119-t1x9gknd 12676 18 Healthcare Healthcare NNP cord-010119-t1x9gknd 12676 19 Background Background NNP cord-010119-t1x9gknd 12676 20 / / SYM cord-010119-t1x9gknd 12676 21 Case Case NNP cord-010119-t1x9gknd 12676 22 Studies Studies NNPS cord-010119-t1x9gknd 12676 23 : : : cord-010119-t1x9gknd 12676 24 The the DT cord-010119-t1x9gknd 12676 25 type type NN cord-010119-t1x9gknd 12676 26 and and CC cord-010119-t1x9gknd 12676 27 screen screen NN cord-010119-t1x9gknd 12676 28 ( ( -LRB- cord-010119-t1x9gknd 12676 29 T&S t&s NN cord-010119-t1x9gknd 12676 30 ) ) -RRB- cord-010119-t1x9gknd 12676 31 is be VBZ cord-010119-t1x9gknd 12676 32 a a DT cord-010119-t1x9gknd 12676 33 fundamental fundamental JJ cord-010119-t1x9gknd 12676 34 laboratory laboratory NN cord-010119-t1x9gknd 12676 35 test test NN cord-010119-t1x9gknd 12676 36 that that WDT cord-010119-t1x9gknd 12676 37 allows allow VBZ cord-010119-t1x9gknd 12676 38 the the DT cord-010119-t1x9gknd 12676 39 blood blood NN cord-010119-t1x9gknd 12676 40 bank bank NN cord-010119-t1x9gknd 12676 41 to to TO cord-010119-t1x9gknd 12676 42 provide provide VB cord-010119-t1x9gknd 12676 43 compatible compatible JJ cord-010119-t1x9gknd 12676 44 blood blood NN cord-010119-t1x9gknd 12676 45 for for IN cord-010119-t1x9gknd 12676 46 patients patient NNS cord-010119-t1x9gknd 12676 47 . . . cord-010119-t1x9gknd 12677 1 Despite despite IN cord-010119-t1x9gknd 12677 2 this this DT cord-010119-t1x9gknd 12677 3 , , , cord-010119-t1x9gknd 12677 4 erroneous erroneous JJ cord-010119-t1x9gknd 12677 5 blood blood NN cord-010119-t1x9gknd 12677 6 product product NN cord-010119-t1x9gknd 12677 7 administration administration NN cord-010119-t1x9gknd 12677 8 may may MD cord-010119-t1x9gknd 12677 9 occur occur VB cord-010119-t1x9gknd 12677 10 as as RB cord-010119-t1x9gknd 12677 11 much much JJ cord-010119-t1x9gknd 12677 12 as as IN cord-010119-t1x9gknd 12677 13 1 1 CD cord-010119-t1x9gknd 12677 14 in in IN cord-010119-t1x9gknd 12677 15 19,000 19,000 CD cord-010119-t1x9gknd 12677 16 blood blood NN cord-010119-t1x9gknd 12677 17 transfusions transfusion NNS cord-010119-t1x9gknd 12677 18 . . . cord-010119-t1x9gknd 12678 1 To to TO cord-010119-t1x9gknd 12678 2 prevent prevent VB cord-010119-t1x9gknd 12678 3 errors error NNS cord-010119-t1x9gknd 12678 4 , , , cord-010119-t1x9gknd 12678 5 adequate adequate JJ cord-010119-t1x9gknd 12678 6 specimens specimen NNS cord-010119-t1x9gknd 12678 7 such such JJ cord-010119-t1x9gknd 12678 8 as as IN cord-010119-t1x9gknd 12678 9 those those DT cord-010119-t1x9gknd 12678 10 lacking lack VBG cord-010119-t1x9gknd 12678 11 hemolysis hemolysis NN cord-010119-t1x9gknd 12678 12 and and CC cord-010119-t1x9gknd 12678 13 those those DT cord-010119-t1x9gknd 12678 14 with with IN cord-010119-t1x9gknd 12678 15 proper proper JJ cord-010119-t1x9gknd 12678 16 specimen specimen JJ cord-010119-t1x9gknd 12678 17 labeling labeling NN cord-010119-t1x9gknd 12678 18 are be VBP cord-010119-t1x9gknd 12678 19 necessary necessary JJ cord-010119-t1x9gknd 12678 20 ; ; : cord-010119-t1x9gknd 12678 21 otherwise otherwise RB cord-010119-t1x9gknd 12678 22 the the DT cord-010119-t1x9gknd 12678 23 specimen specimen NN cord-010119-t1x9gknd 12678 24 is be VBZ cord-010119-t1x9gknd 12678 25 rejected reject VBN cord-010119-t1x9gknd 12678 26 , , , cord-010119-t1x9gknd 12678 27 leading lead VBG cord-010119-t1x9gknd 12678 28 to to IN cord-010119-t1x9gknd 12678 29 a a DT cord-010119-t1x9gknd 12678 30 second second JJ cord-010119-t1x9gknd 12678 31 blood blood NN cord-010119-t1x9gknd 12678 32 draw draw NN cord-010119-t1x9gknd 12678 33 and and CC cord-010119-t1x9gknd 12678 34 a a DT cord-010119-t1x9gknd 12678 35 delay delay NN cord-010119-t1x9gknd 12678 36 in in IN cord-010119-t1x9gknd 12678 37 medical medical JJ cord-010119-t1x9gknd 12678 38 / / SYM cord-010119-t1x9gknd 12678 39 surgical surgical JJ cord-010119-t1x9gknd 12678 40 management management NN cord-010119-t1x9gknd 12678 41 . . . cord-010119-t1x9gknd 12679 1 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 12679 2 rates rate NNS cord-010119-t1x9gknd 12679 3 for for IN cord-010119-t1x9gknd 12679 4 T&S t&s NN cord-010119-t1x9gknd 12679 5 specimens specimen NNS cord-010119-t1x9gknd 12679 6 are be VBP cord-010119-t1x9gknd 12679 7 reported report VBN cord-010119-t1x9gknd 12679 8 to to TO cord-010119-t1x9gknd 12679 9 be be VB cord-010119-t1x9gknd 12679 10 as as RB cord-010119-t1x9gknd 12679 11 high high JJ cord-010119-t1x9gknd 12679 12 as as IN cord-010119-t1x9gknd 12679 13 25 25 CD cord-010119-t1x9gknd 12679 14 % % NN cord-010119-t1x9gknd 12679 15 prior prior RB cord-010119-t1x9gknd 12679 16 to to IN cord-010119-t1x9gknd 12679 17 interventions intervention NNS cord-010119-t1x9gknd 12679 18 , , , cord-010119-t1x9gknd 12679 19 but but CC cord-010119-t1x9gknd 12679 20 may may MD cord-010119-t1x9gknd 12679 21 potentially potentially RB cord-010119-t1x9gknd 12679 22 be be VB cord-010119-t1x9gknd 12679 23 reduced reduce VBN cord-010119-t1x9gknd 12679 24 to to IN cord-010119-t1x9gknd 12679 25 as as RB cord-010119-t1x9gknd 12679 26 little little JJ cord-010119-t1x9gknd 12679 27 as as IN cord-010119-t1x9gknd 12679 28 1.5 1.5 CD cord-010119-t1x9gknd 12679 29 % % NN cord-010119-t1x9gknd 12679 30 . . . cord-010119-t1x9gknd 12680 1 However however RB cord-010119-t1x9gknd 12680 2 , , , cord-010119-t1x9gknd 12680 3 there there EX cord-010119-t1x9gknd 12680 4 is be VBZ cord-010119-t1x9gknd 12680 5 little little JJ cord-010119-t1x9gknd 12680 6 published publish VBN cord-010119-t1x9gknd 12680 7 data datum NNS cord-010119-t1x9gknd 12680 8 on on IN cord-010119-t1x9gknd 12680 9 non non JJ cord-010119-t1x9gknd 12680 10 - - JJ cord-010119-t1x9gknd 12680 11 hemolysis hemolysis NN cord-010119-t1x9gknd 12680 12 - - HYPH cord-010119-t1x9gknd 12680 13 related relate VBN cord-010119-t1x9gknd 12680 14 type type NN cord-010119-t1x9gknd 12680 15 and and CC cord-010119-t1x9gknd 12680 16 screen screen NN cord-010119-t1x9gknd 12680 17 rejections rejection NNS cord-010119-t1x9gknd 12680 18 . . . cord-010119-t1x9gknd 12681 1 An an DT cord-010119-t1x9gknd 12681 2 initiative initiative NN cord-010119-t1x9gknd 12681 3 was be VBD cord-010119-t1x9gknd 12681 4 undertaken undertake VBN cord-010119-t1x9gknd 12681 5 to to TO cord-010119-t1x9gknd 12681 6 reduce reduce VB cord-010119-t1x9gknd 12681 7 the the DT cord-010119-t1x9gknd 12681 8 rejection rejection NN cord-010119-t1x9gknd 12681 9 rate rate NN cord-010119-t1x9gknd 12681 10 in in IN cord-010119-t1x9gknd 12681 11 the the DT cord-010119-t1x9gknd 12681 12 blood blood NN cord-010119-t1x9gknd 12681 13 bank bank NN cord-010119-t1x9gknd 12681 14 to to IN cord-010119-t1x9gknd 12681 15 a a DT cord-010119-t1x9gknd 12681 16 sustained sustained JJ cord-010119-t1x9gknd 12681 17 rate rate NN cord-010119-t1x9gknd 12681 18 of of IN cord-010119-t1x9gknd 12681 19 < < NNP cord-010119-t1x9gknd 12681 20 5 5 CD cord-010119-t1x9gknd 12681 21 % % NN cord-010119-t1x9gknd 12681 22 , , , cord-010119-t1x9gknd 12681 23 with with IN cord-010119-t1x9gknd 12681 24 a a DT cord-010119-t1x9gknd 12681 25 particular particular JJ cord-010119-t1x9gknd 12681 26 emphasis emphasis NN cord-010119-t1x9gknd 12681 27 on on IN cord-010119-t1x9gknd 12681 28 non non JJ cord-010119-t1x9gknd 12681 29 - - JJ cord-010119-t1x9gknd 12681 30 hemolysisassociated hemolysisassociated JJ cord-010119-t1x9gknd 12681 31 forms form NNS cord-010119-t1x9gknd 12681 32 of of IN cord-010119-t1x9gknd 12681 33 rejection rejection NN cord-010119-t1x9gknd 12681 34 . . . cord-010119-t1x9gknd 12682 1 Study Study NNP cord-010119-t1x9gknd 12682 2 Design Design NNP cord-010119-t1x9gknd 12682 3 / / SYM cord-010119-t1x9gknd 12682 4 Method method NN cord-010119-t1x9gknd 12682 5 : : : cord-010119-t1x9gknd 12683 1 A a DT cord-010119-t1x9gknd 12683 2 root root NN cord-010119-t1x9gknd 12683 3 cause cause NN cord-010119-t1x9gknd 12683 4 analysis analysis NN cord-010119-t1x9gknd 12683 5 ( ( -LRB- cord-010119-t1x9gknd 12683 6 RCA RCA NNP cord-010119-t1x9gknd 12683 7 ) ) -RRB- cord-010119-t1x9gknd 12683 8 was be VBD cord-010119-t1x9gknd 12683 9 performed perform VBN cord-010119-t1x9gknd 12683 10 over over IN cord-010119-t1x9gknd 12683 11 the the DT cord-010119-t1x9gknd 12683 12 preceding precede VBG cord-010119-t1x9gknd 12683 13 6 6 CD cord-010119-t1x9gknd 12683 14 months month NNS cord-010119-t1x9gknd 12683 15 to to TO cord-010119-t1x9gknd 12683 16 obtain obtain VB cord-010119-t1x9gknd 12683 17 a a DT cord-010119-t1x9gknd 12683 18 baseline baseline JJ cord-010119-t1x9gknd 12683 19 understanding understanding NN cord-010119-t1x9gknd 12683 20 of of IN cord-010119-t1x9gknd 12683 21 the the DT cord-010119-t1x9gknd 12683 22 errors error NNS cord-010119-t1x9gknd 12683 23 involved involve VBN cord-010119-t1x9gknd 12683 24 . . . cord-010119-t1x9gknd 12684 1 T&S t&s NN cord-010119-t1x9gknd 12684 2 submission submission NN cord-010119-t1x9gknd 12684 3 at at IN cord-010119-t1x9gknd 12684 4 our -PRON- PRP$ cord-010119-t1x9gknd 12684 5 facility facility NN cord-010119-t1x9gknd 12684 6 involves involve VBZ cord-010119-t1x9gknd 12684 7 standard standard JJ cord-010119-t1x9gknd 12684 8 completion completion NN cord-010119-t1x9gknd 12684 9 of of IN cord-010119-t1x9gknd 12684 10 the the DT cord-010119-t1x9gknd 12684 11 specimen specimen JJ cord-010119-t1x9gknd 12684 12 label label NN cord-010119-t1x9gknd 12684 13 plus plus CC cord-010119-t1x9gknd 12684 14 completion completion NN cord-010119-t1x9gknd 12684 15 of of IN cord-010119-t1x9gknd 12684 16 a a DT cord-010119-t1x9gknd 12684 17 unique unique JJ cord-010119-t1x9gknd 12684 18 witness witness NN cord-010119-t1x9gknd 12684 19 form form NN cord-010119-t1x9gknd 12684 20 to to TO cord-010119-t1x9gknd 12684 21 confirm confirm VB cord-010119-t1x9gknd 12684 22 the the DT cord-010119-t1x9gknd 12684 23 identity identity NN cord-010119-t1x9gknd 12684 24 of of IN cord-010119-t1x9gknd 12684 25 the the DT cord-010119-t1x9gknd 12684 26 patient patient NN cord-010119-t1x9gknd 12684 27 from from IN cord-010119-t1x9gknd 12684 28 whom whom WP cord-010119-t1x9gknd 12684 29 the the DT cord-010119-t1x9gknd 12684 30 specimen specimen NN cord-010119-t1x9gknd 12684 31 was be VBD cord-010119-t1x9gknd 12684 32 collected collect VBN cord-010119-t1x9gknd 12684 33 ; ; : cord-010119-t1x9gknd 12684 34 specimen specimen NN cord-010119-t1x9gknd 12684 35 and and CC cord-010119-t1x9gknd 12684 36 witness witness NN cord-010119-t1x9gknd 12684 37 form form NN cord-010119-t1x9gknd 12684 38 must must MD cord-010119-t1x9gknd 12684 39 be be VB cord-010119-t1x9gknd 12684 40 submitted submit VBN cord-010119-t1x9gknd 12684 41 simultaneously simultaneously RB cord-010119-t1x9gknd 12684 42 . . . cord-010119-t1x9gknd 12685 1 When when WRB cord-010119-t1x9gknd 12685 2 a a DT cord-010119-t1x9gknd 12685 3 specimen specimen NN cord-010119-t1x9gknd 12685 4 was be VBD cord-010119-t1x9gknd 12685 5 rejected reject VBN cord-010119-t1x9gknd 12685 6 , , , cord-010119-t1x9gknd 12685 7 we -PRON- PRP cord-010119-t1x9gknd 12685 8 recorded record VBD cord-010119-t1x9gknd 12685 9 the the DT cord-010119-t1x9gknd 12685 10 patient patient NN cord-010119-t1x9gknd 12685 11 name name NN cord-010119-t1x9gknd 12685 12 , , , cord-010119-t1x9gknd 12685 13 medical medical JJ cord-010119-t1x9gknd 12685 14 record record NN cord-010119-t1x9gknd 12685 15 number number NN cord-010119-t1x9gknd 12685 16 , , , cord-010119-t1x9gknd 12685 17 and and CC cord-010119-t1x9gknd 12685 18 the the DT cord-010119-t1x9gknd 12685 19 reason reason NN cord-010119-t1x9gknd 12685 20 for for IN cord-010119-t1x9gknd 12685 21 rejection rejection NN cord-010119-t1x9gknd 12685 22 . . . cord-010119-t1x9gknd 12686 1 Following follow VBG cord-010119-t1x9gknd 12686 2 RCA RCA NNP cord-010119-t1x9gknd 12686 3 , , , cord-010119-t1x9gknd 12686 4 an an DT cord-010119-t1x9gknd 12686 5 intervention intervention NN cord-010119-t1x9gknd 12686 6 was be VBD cord-010119-t1x9gknd 12686 7 created create VBN cord-010119-t1x9gknd 12686 8 to to TO cord-010119-t1x9gknd 12686 9 resolve resolve VB cord-010119-t1x9gknd 12686 10 the the DT cord-010119-t1x9gknd 12686 11 most most RBS cord-010119-t1x9gknd 12686 12 common common JJ cord-010119-t1x9gknd 12686 13 issues issue NNS cord-010119-t1x9gknd 12686 14 documented document VBD cord-010119-t1x9gknd 12686 15 that that WDT cord-010119-t1x9gknd 12686 16 resulted result VBD cord-010119-t1x9gknd 12686 17 in in IN cord-010119-t1x9gknd 12686 18 rejection rejection NN cord-010119-t1x9gknd 12686 19 . . . cord-010119-t1x9gknd 12687 1 Approval approval NN cord-010119-t1x9gknd 12687 2 for for IN cord-010119-t1x9gknd 12687 3 the the DT cord-010119-t1x9gknd 12687 4 intervention intervention NN cord-010119-t1x9gknd 12687 5 was be VBD cord-010119-t1x9gknd 12687 6 granted grant VBN cord-010119-t1x9gknd 12687 7 by by IN cord-010119-t1x9gknd 12687 8 the the DT cord-010119-t1x9gknd 12687 9 Department Department NNP cord-010119-t1x9gknd 12687 10 Chair Chair NNP cord-010119-t1x9gknd 12687 11 , , , cord-010119-t1x9gknd 12687 12 Transfusion Transfusion NNP cord-010119-t1x9gknd 12687 13 Committee Committee NNP cord-010119-t1x9gknd 12687 14 , , , cord-010119-t1x9gknd 12687 15 Forms Forms NNP cord-010119-t1x9gknd 12687 16 Committee Committee NNP cord-010119-t1x9gknd 12687 17 , , , cord-010119-t1x9gknd 12687 18 and and CC cord-010119-t1x9gknd 12687 19 the the DT cord-010119-t1x9gknd 12687 20 Medical Medical NNP cord-010119-t1x9gknd 12687 21 Executive Executive NNP cord-010119-t1x9gknd 12687 22 Committee Committee NNP cord-010119-t1x9gknd 12687 23 . . . cord-010119-t1x9gknd 12688 1 After after IN cord-010119-t1x9gknd 12688 2 implementation implementation NN cord-010119-t1x9gknd 12688 3 , , , cord-010119-t1x9gknd 12688 4 prospective prospective JJ cord-010119-t1x9gknd 12688 5 data datum NNS cord-010119-t1x9gknd 12688 6 will will MD cord-010119-t1x9gknd 12688 7 be be VB cord-010119-t1x9gknd 12688 8 collected collect VBN cord-010119-t1x9gknd 12688 9 for for IN cord-010119-t1x9gknd 12688 10 several several JJ cord-010119-t1x9gknd 12688 11 months month NNS cord-010119-t1x9gknd 12688 12 in in IN cord-010119-t1x9gknd 12688 13 the the DT cord-010119-t1x9gknd 12688 14 same same JJ cord-010119-t1x9gknd 12688 15 manner manner NN cord-010119-t1x9gknd 12688 16 as as IN cord-010119-t1x9gknd 12688 17 before before RB cord-010119-t1x9gknd 12688 18 to to TO cord-010119-t1x9gknd 12688 19 determine determine VB cord-010119-t1x9gknd 12688 20 the the DT cord-010119-t1x9gknd 12688 21 effectiveness effectiveness NN cord-010119-t1x9gknd 12688 22 of of IN cord-010119-t1x9gknd 12688 23 the the DT cord-010119-t1x9gknd 12688 24 intervention intervention NN cord-010119-t1x9gknd 12688 25 . . . cord-010119-t1x9gknd 12689 1 Results result NNS cord-010119-t1x9gknd 12689 2 / / SYM cord-010119-t1x9gknd 12689 3 Finding finding NN cord-010119-t1x9gknd 12689 4 : : : cord-010119-t1x9gknd 12689 5 Over over IN cord-010119-t1x9gknd 12689 6 the the DT cord-010119-t1x9gknd 12689 7 study study NN cord-010119-t1x9gknd 12689 8 period period NN cord-010119-t1x9gknd 12689 9 , , , cord-010119-t1x9gknd 12689 10 the the DT cord-010119-t1x9gknd 12689 11 T&S T&S NNP cord-010119-t1x9gknd 12689 12 rejection rejection NN cord-010119-t1x9gknd 12689 13 rate rate NN cord-010119-t1x9gknd 12689 14 averaged average VBD cord-010119-t1x9gknd 12689 15 8.2 8.2 CD cord-010119-t1x9gknd 12689 16 % % NN cord-010119-t1x9gknd 12689 17 . . . cord-010119-t1x9gknd 12690 1 Reasons reason NNS cord-010119-t1x9gknd 12690 2 for for IN cord-010119-t1x9gknd 12690 3 specimen specimen JJ cord-010119-t1x9gknd 12690 4 rejection rejection NN cord-010119-t1x9gknd 12690 5 were be VBD cord-010119-t1x9gknd 12690 6 divided divide VBN cord-010119-t1x9gknd 12690 7 into into IN cord-010119-t1x9gknd 12690 8 5 5 CD cord-010119-t1x9gknd 12690 9 groups group NNS cord-010119-t1x9gknd 12690 10 : : : cord-010119-t1x9gknd 12690 11 1 1 LS cord-010119-t1x9gknd 12690 12 ) ) -RRB- cord-010119-t1x9gknd 12690 13 hemolysis hemolysis NN cord-010119-t1x9gknd 12690 14 , , , cord-010119-t1x9gknd 12690 15 2 2 CD cord-010119-t1x9gknd 12690 16 ) ) -RRB- cord-010119-t1x9gknd 12690 17 blood blood NN cord-010119-t1x9gknd 12690 18 bank bank NN cord-010119-t1x9gknd 12690 19 witness witness NN cord-010119-t1x9gknd 12690 20 collection collection NN cord-010119-t1x9gknd 12690 21 form form NN cord-010119-t1x9gknd 12690 22 errors error NNS cord-010119-t1x9gknd 12690 23 , , , cord-010119-t1x9gknd 12690 24 3 3 CD cord-010119-t1x9gknd 12690 25 ) ) -RRB- cord-010119-t1x9gknd 12690 26 quantity quantity NN cord-010119-t1x9gknd 12690 27 not not RB cord-010119-t1x9gknd 12690 28 sufficient sufficient JJ cord-010119-t1x9gknd 12690 29 , , , cord-010119-t1x9gknd 12690 30 ABSTRACT abstract JJ cord-010119-t1x9gknd 12690 31 4 4 CD cord-010119-t1x9gknd 12690 32 ) ) -RRB- cord-010119-t1x9gknd 12690 33 duplicate duplicate VB cord-010119-t1x9gknd 12690 34 sample sample NN cord-010119-t1x9gknd 12690 35 , , , cord-010119-t1x9gknd 12690 36 and and CC cord-010119-t1x9gknd 12690 37 5 5 LS cord-010119-t1x9gknd 12690 38 ) ) -RRB- cord-010119-t1x9gknd 12690 39 specimen specimen JJ cord-010119-t1x9gknd 12690 40 tube tube NN cord-010119-t1x9gknd 12690 41 labelling labelling NN cord-010119-t1x9gknd 12690 42 errors error NNS cord-010119-t1x9gknd 12690 43 . . . cord-010119-t1x9gknd 12691 1 The the DT cord-010119-t1x9gknd 12691 2 highest high JJS cord-010119-t1x9gknd 12691 3 percentage percentage NN cord-010119-t1x9gknd 12691 4 of of IN cord-010119-t1x9gknd 12691 5 rejections rejection NNS cord-010119-t1x9gknd 12691 6 was be VBD cord-010119-t1x9gknd 12691 7 due due JJ cord-010119-t1x9gknd 12691 8 to to IN cord-010119-t1x9gknd 12691 9 improperly improperly RB cord-010119-t1x9gknd 12691 10 - - HYPH cord-010119-t1x9gknd 12691 11 filled fill VBN cord-010119-t1x9gknd 12691 12 witness witness NN cord-010119-t1x9gknd 12691 13 forms form NNS cord-010119-t1x9gknd 12691 14 ( ( -LRB- cord-010119-t1x9gknd 12691 15 Table table NN cord-010119-t1x9gknd 12691 16 1 1 CD cord-010119-t1x9gknd 12691 17 ) ) -RRB- cord-010119-t1x9gknd 12691 18 . . . cord-010119-t1x9gknd 12692 1 After after IN cord-010119-t1x9gknd 12692 2 multiple multiple JJ cord-010119-t1x9gknd 12692 3 form form NN cord-010119-t1x9gknd 12692 4 redesigns redesign NNS cord-010119-t1x9gknd 12692 5 and and CC cord-010119-t1x9gknd 12692 6 approval approval NN cord-010119-t1x9gknd 12692 7 by by IN cord-010119-t1x9gknd 12692 8 appropriate appropriate JJ cord-010119-t1x9gknd 12692 9 committees committee NNS cord-010119-t1x9gknd 12692 10 the the DT cord-010119-t1x9gknd 12692 11 new new JJ cord-010119-t1x9gknd 12692 12 form form NN cord-010119-t1x9gknd 12692 13 was be VBD cord-010119-t1x9gknd 12692 14 implemented implement VBN cord-010119-t1x9gknd 12692 15 . . . cord-010119-t1x9gknd 12693 1 Preliminary preliminary JJ cord-010119-t1x9gknd 12693 2 data datum NNS cord-010119-t1x9gknd 12693 3 collected collect VBN cord-010119-t1x9gknd 12693 4 thus thus RB cord-010119-t1x9gknd 12693 5 far far RB cord-010119-t1x9gknd 12693 6 demonstrates demonstrate VBZ cord-010119-t1x9gknd 12693 7 a a DT cord-010119-t1x9gknd 12693 8 6.8 6.8 CD cord-010119-t1x9gknd 12693 9 % % NN cord-010119-t1x9gknd 12693 10 rejection rejection NN cord-010119-t1x9gknd 12693 11 rate rate NN cord-010119-t1x9gknd 12693 12 with with IN cord-010119-t1x9gknd 12693 13 only only RB cord-010119-t1x9gknd 12693 14 1 1 CD cord-010119-t1x9gknd 12693 15 rejection rejection NN cord-010119-t1x9gknd 12693 16 relating relate VBG cord-010119-t1x9gknd 12693 17 to to IN cord-010119-t1x9gknd 12693 18 witness witness NN cord-010119-t1x9gknd 12693 19 form form NN cord-010119-t1x9gknd 12693 20 errors error NNS cord-010119-t1x9gknd 12693 21 . . . cord-010119-t1x9gknd 12694 1 Conclusion conclusion NN cord-010119-t1x9gknd 12694 2 : : : cord-010119-t1x9gknd 12695 1 Rejected reject VBN cord-010119-t1x9gknd 12695 2 T&S T&S NNP cord-010119-t1x9gknd 12695 3 specimens specimen NNS cord-010119-t1x9gknd 12695 4 are be VBP cord-010119-t1x9gknd 12695 5 an an DT cord-010119-t1x9gknd 12695 6 impediment impediment NN cord-010119-t1x9gknd 12695 7 to to TO cord-010119-t1x9gknd 12695 8 safe safe JJ cord-010119-t1x9gknd 12695 9 clinical clinical JJ cord-010119-t1x9gknd 12695 10 care care NN cord-010119-t1x9gknd 12695 11 as as IN cord-010119-t1x9gknd 12695 12 it -PRON- PRP cord-010119-t1x9gknd 12695 13 may may MD cord-010119-t1x9gknd 12695 14 delay delay VB cord-010119-t1x9gknd 12695 15 medical medical JJ cord-010119-t1x9gknd 12695 16 / / SYM cord-010119-t1x9gknd 12695 17 surgical surgical JJ cord-010119-t1x9gknd 12695 18 management management NN cord-010119-t1x9gknd 12695 19 . . . cord-010119-t1x9gknd 12696 1 Rejection rejection NN cord-010119-t1x9gknd 12696 2 rates rate NNS cord-010119-t1x9gknd 12696 3 could could MD cord-010119-t1x9gknd 12696 4 be be VB cord-010119-t1x9gknd 12696 5 reduced reduce VBN cord-010119-t1x9gknd 12696 6 through through IN cord-010119-t1x9gknd 12696 7 simplification simplification NN cord-010119-t1x9gknd 12696 8 of of IN cord-010119-t1x9gknd 12696 9 blood blood NN cord-010119-t1x9gknd 12696 10 bank bank NN cord-010119-t1x9gknd 12696 11 specimen specimen NN cord-010119-t1x9gknd 12696 12 collection collection NN cord-010119-t1x9gknd 12696 13 forms form NNS cord-010119-t1x9gknd 12696 14 . . . cord-010119-t1x9gknd 12697 1 Care care NN cord-010119-t1x9gknd 12697 2 providers provider NNS cord-010119-t1x9gknd 12697 3 have have VBP cord-010119-t1x9gknd 12697 4 multiple multiple JJ cord-010119-t1x9gknd 12697 5 tasks task NNS cord-010119-t1x9gknd 12697 6 that that WDT cord-010119-t1x9gknd 12697 7 need need VBP cord-010119-t1x9gknd 12697 8 to to TO cord-010119-t1x9gknd 12697 9 be be VB cord-010119-t1x9gknd 12697 10 performed perform VBN cord-010119-t1x9gknd 12697 11 in in IN cord-010119-t1x9gknd 12697 12 a a DT cord-010119-t1x9gknd 12697 13 short short JJ cord-010119-t1x9gknd 12697 14 amount amount NN cord-010119-t1x9gknd 12697 15 of of IN cord-010119-t1x9gknd 12697 16 time time NN cord-010119-t1x9gknd 12697 17 , , , cord-010119-t1x9gknd 12697 18 therefore therefore RB cord-010119-t1x9gknd 12697 19 , , , cord-010119-t1x9gknd 12697 20 simplification simplification NN cord-010119-t1x9gknd 12697 21 is be VBZ cord-010119-t1x9gknd 12697 22 often often RB cord-010119-t1x9gknd 12697 23 times time NNS cord-010119-t1x9gknd 12697 24 necessary necessary JJ cord-010119-t1x9gknd 12697 25 to to TO cord-010119-t1x9gknd 12697 26 reduce reduce VB cord-010119-t1x9gknd 12697 27 human human JJ cord-010119-t1x9gknd 12697 28 error error NN cord-010119-t1x9gknd 12697 29 . . . cord-010119-t1x9gknd 12698 1 Future future JJ cord-010119-t1x9gknd 12698 2 quality quality NN cord-010119-t1x9gknd 12698 3 initiatives initiative NNS cord-010119-t1x9gknd 12698 4 will will MD cord-010119-t1x9gknd 12698 5 aim aim VB cord-010119-t1x9gknd 12698 6 to to TO cord-010119-t1x9gknd 12698 7 simplify simplify VB cord-010119-t1x9gknd 12698 8 complex complex JJ cord-010119-t1x9gknd 12698 9 healthcare healthcare NN cord-010119-t1x9gknd 12698 10 processes process NNS cord-010119-t1x9gknd 12698 11 without without IN cord-010119-t1x9gknd 12698 12 compromising compromise VBG cord-010119-t1x9gknd 12698 13 patient patient JJ cord-010119-t1x9gknd 12698 14 care care NN cord-010119-t1x9gknd 12698 15 . . . cord-010119-t1x9gknd 12699 1 Reduction reduction NN cord-010119-t1x9gknd 12699 2 of of IN cord-010119-t1x9gknd 12699 3 Failed Failed NNP cord-010119-t1x9gknd 12699 4 Whole Whole NNP cord-010119-t1x9gknd 12699 5 Blood Blood NNP cord-010119-t1x9gknd 12699 6 Donor Donor NNP cord-010119-t1x9gknd 12699 7 Testing Testing NNP cord-010119-t1x9gknd 12699 8 Runs run VBZ cord-010119-t1x9gknd 12699 9 on on IN cord-010119-t1x9gknd 12699 10 the the DT cord-010119-t1x9gknd 12699 11 Roche Roche NNP cord-010119-t1x9gknd 12699 12 Cobas Cobas NNP cord-010119-t1x9gknd 12699 13 s s POS cord-010119-t1x9gknd 12699 14 201 201 CD cord-010119-t1x9gknd 12699 15 System system NN cord-010119-t1x9gknd 12699 16 Christopher Christopher NNP cord-010119-t1x9gknd 12699 17 Shahan Shahan NNP cord-010119-t1x9gknd 12700 1 * * NFP cord-010119-t1x9gknd 12700 2 1 1 CD cord-010119-t1x9gknd 12700 3 , , , cord-010119-t1x9gknd 12700 4 Christina Christina NNP cord-010119-t1x9gknd 12700 5 DeJesus DeJesus NNP cord-010119-t1x9gknd 12700 6 1 1 CD cord-010119-t1x9gknd 12700 7 , , , cord-010119-t1x9gknd 12700 8 Mosi Mosi NNP cord-010119-t1x9gknd 12700 9 McCall McCall NNP cord-010119-t1x9gknd 12700 10 1 1 CD cord-010119-t1x9gknd 12700 11 , , , cord-010119-t1x9gknd 12700 12 Fallon Fallon NNP cord-010119-t1x9gknd 12700 13 Hampton Hampton NNP cord-010119-t1x9gknd 12700 14 1 1 CD cord-010119-t1x9gknd 12700 15 , , , cord-010119-t1x9gknd 12700 16 Tangi Tangi NNP cord-010119-t1x9gknd 12700 17 Herring Herring NNP cord-010119-t1x9gknd 12700 18 1 1 CD cord-010119-t1x9gknd 12700 19 , , , cord-010119-t1x9gknd 12700 20 Judy Judy NNP cord-010119-t1x9gknd 12700 21 Davis Davis NNP cord-010119-t1x9gknd 12700 22 1 1 CD cord-010119-t1x9gknd 12700 23 , , , cord-010119-t1x9gknd 12700 24 Anjali Anjali NNP cord-010119-t1x9gknd 12700 25 Patel Patel NNP cord-010119-t1x9gknd 12700 26 1 1 CD cord-010119-t1x9gknd 12700 27 , , , cord-010119-t1x9gknd 12700 28 Sonya Sonya NNP cord-010119-t1x9gknd 12700 29 Gomillion Gomillion NNP cord-010119-t1x9gknd 12700 30 1 1 CD cord-010119-t1x9gknd 12700 31 and and CC cord-010119-t1x9gknd 12700 32 Bonnie Bonnie NNP cord-010119-t1x9gknd 12700 33 Maltby Maltby NNP cord-010119-t1x9gknd 12700 34 2 2 CD cord-010119-t1x9gknd 12700 35 . . . cord-010119-t1x9gknd 12701 1 1 1 CD cord-010119-t1x9gknd 12701 2 QualTex QualTex NNP cord-010119-t1x9gknd 12701 3 Laboratories Laboratories NNPS cord-010119-t1x9gknd 12701 4 , , , cord-010119-t1x9gknd 12701 5 2 2 CD cord-010119-t1x9gknd 12701 6 QualTex QualTex NNP cord-010119-t1x9gknd 12701 7 laboratories laboratory NNS cord-010119-t1x9gknd 12701 8 Background Background NNP cord-010119-t1x9gknd 12701 9 / / SYM cord-010119-t1x9gknd 12701 10 Case Case NNP cord-010119-t1x9gknd 12701 11 Studies Studies NNPS cord-010119-t1x9gknd 12701 12 : : : cord-010119-t1x9gknd 12702 1 As as IN cord-010119-t1x9gknd 12702 2 part part NN cord-010119-t1x9gknd 12702 3 of of IN cord-010119-t1x9gknd 12702 4 our -PRON- PRP$ cord-010119-t1x9gknd 12702 5 quality quality NN cord-010119-t1x9gknd 12702 6 control control NN cord-010119-t1x9gknd 12702 7 program program NN cord-010119-t1x9gknd 12702 8 , , , cord-010119-t1x9gknd 12702 9 we -PRON- PRP cord-010119-t1x9gknd 12702 10 track track VBP cord-010119-t1x9gknd 12702 11 the the DT cord-010119-t1x9gknd 12702 12 number number NN cord-010119-t1x9gknd 12702 13 of of IN cord-010119-t1x9gknd 12702 14 technician technician NN cord-010119-t1x9gknd 12702 15 related relate VBN cord-010119-t1x9gknd 12702 16 failed fail VBD cord-010119-t1x9gknd 12702 17 runs run NNS cord-010119-t1x9gknd 12702 18 observed observe VBN cord-010119-t1x9gknd 12702 19 on on IN cord-010119-t1x9gknd 12702 20 the the DT cord-010119-t1x9gknd 12702 21 Roche Roche NNP cord-010119-t1x9gknd 12702 22 cobas cobas NNP cord-010119-t1x9gknd 12702 23 s s POS cord-010119-t1x9gknd 12702 24 201 201 CD cord-010119-t1x9gknd 12702 25 System System NNP cord-010119-t1x9gknd 12702 26 . . . cord-010119-t1x9gknd 12703 1 This this DT cord-010119-t1x9gknd 12703 2 system system NN cord-010119-t1x9gknd 12703 3 is be VBZ cord-010119-t1x9gknd 12703 4 used use VBN cord-010119-t1x9gknd 12703 5 to to TO cord-010119-t1x9gknd 12703 6 test test VB cord-010119-t1x9gknd 12703 7 whole whole JJ cord-010119-t1x9gknd 12703 8 blood blood NN cord-010119-t1x9gknd 12703 9 donor donor NN cord-010119-t1x9gknd 12703 10 samples sample NNS cord-010119-t1x9gknd 12703 11 for for IN cord-010119-t1x9gknd 12703 12 Human Human NNP cord-010119-t1x9gknd 12703 13 Immunodeficiency Immunodeficiency NNP cord-010119-t1x9gknd 12703 14 Virus Virus NNP cord-010119-t1x9gknd 12703 15 ( ( -LRB- cord-010119-t1x9gknd 12703 16 HIV HIV NNP cord-010119-t1x9gknd 12703 17 ) ) -RRB- cord-010119-t1x9gknd 12703 18 RNA RNA NNP cord-010119-t1x9gknd 12703 19 , , , cord-010119-t1x9gknd 12703 20 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 12703 21 C C NNP cord-010119-t1x9gknd 12703 22 Virus Virus NNP cord-010119-t1x9gknd 12703 23 ( ( -LRB- cord-010119-t1x9gknd 12703 24 HCV HCV NNP cord-010119-t1x9gknd 12703 25 ) ) -RRB- cord-010119-t1x9gknd 12703 26 RNA RNA NNP cord-010119-t1x9gknd 12703 27 , , , cord-010119-t1x9gknd 12703 28 Hepatitis Hepatitis NNP cord-010119-t1x9gknd 12703 29 B B NNP cord-010119-t1x9gknd 12703 30 Virus Virus NNP cord-010119-t1x9gknd 12703 31 ( ( -LRB- cord-010119-t1x9gknd 12703 32 HBV HBV NNP cord-010119-t1x9gknd 12703 33 ) ) -RRB- cord-010119-t1x9gknd 12703 34 DNA DNA NNP cord-010119-t1x9gknd 12703 35 and and CC cord-010119-t1x9gknd 12703 36 West West NNP cord-010119-t1x9gknd 12703 37 Nile Nile NNP cord-010119-t1x9gknd 12703 38 Virus Virus NNP cord-010119-t1x9gknd 12703 39 ( ( -LRB- cord-010119-t1x9gknd 12703 40 WNV WNV NNP cord-010119-t1x9gknd 12703 41 ) ) -RRB- cord-010119-t1x9gknd 12703 42 RNA RNA NNP cord-010119-t1x9gknd 12703 43 . . . cord-010119-t1x9gknd 12704 1 Technician Technician NNP cord-010119-t1x9gknd 12704 2 related relate VBN cord-010119-t1x9gknd 12704 3 failed fail VBD cord-010119-t1x9gknd 12704 4 testing testing NN cord-010119-t1x9gknd 12704 5 runs run NNS cord-010119-t1x9gknd 12704 6 can can MD cord-010119-t1x9gknd 12704 7 cause cause VB cord-010119-t1x9gknd 12704 8 the the DT cord-010119-t1x9gknd 12704 9 laboratory laboratory NN cord-010119-t1x9gknd 12704 10 to to TO cord-010119-t1x9gknd 12704 11 report report VB cord-010119-t1x9gknd 12704 12 results result NNS cord-010119-t1x9gknd 12704 13 outside outside RB cord-010119-t1x9gknd 12704 14 of of IN cord-010119-t1x9gknd 12704 15 the the DT cord-010119-t1x9gknd 12704 16 contractual contractual JJ cord-010119-t1x9gknd 12704 17 10 10 CD cord-010119-t1x9gknd 12704 18 - - SYM cord-010119-t1x9gknd 12704 19 12 12 CD cord-010119-t1x9gknd 12704 20 hour hour NN cord-010119-t1x9gknd 12704 21 turnaround turnaround NN cord-010119-t1x9gknd 12704 22 time time NN cord-010119-t1x9gknd 12704 23 . . . cord-010119-t1x9gknd 12705 1 Failed fail VBN cord-010119-t1x9gknd 12705 2 runs run NNS cord-010119-t1x9gknd 12705 3 also also RB cord-010119-t1x9gknd 12705 4 cause cause VBP cord-010119-t1x9gknd 12705 5 retesting reteste VBG cord-010119-t1x9gknd 12705 6 which which WDT cord-010119-t1x9gknd 12705 7 increases increase VBZ cord-010119-t1x9gknd 12705 8 reagent reagent JJ cord-010119-t1x9gknd 12705 9 utilization utilization NN cord-010119-t1x9gknd 12705 10 for for IN cord-010119-t1x9gknd 12705 11 the the DT cord-010119-t1x9gknd 12705 12 system system NN cord-010119-t1x9gknd 12705 13 . . . cord-010119-t1x9gknd 12706 1 Currently currently RB cord-010119-t1x9gknd 12706 2 42 42 CD cord-010119-t1x9gknd 12706 3 % % NN cord-010119-t1x9gknd 12706 4 of of IN cord-010119-t1x9gknd 12706 5 whole whole JJ cord-010119-t1x9gknd 12706 6 blood blood NN cord-010119-t1x9gknd 12706 7 donor donor NN cord-010119-t1x9gknd 12706 8 testing testing NN cord-010119-t1x9gknd 12706 9 turnaround turnaround NN cord-010119-t1x9gknd 12706 10 time time NN cord-010119-t1x9gknd 12706 11 delays delay NNS cord-010119-t1x9gknd 12706 12 are be VBP cord-010119-t1x9gknd 12706 13 due due JJ cord-010119-t1x9gknd 12706 14 to to IN cord-010119-t1x9gknd 12706 15 issues issue NNS cord-010119-t1x9gknd 12706 16 and and CC cord-010119-t1x9gknd 12706 17 failed fail VBD cord-010119-t1x9gknd 12706 18 runs run NNS cord-010119-t1x9gknd 12706 19 on on IN cord-010119-t1x9gknd 12706 20 the the DT cord-010119-t1x9gknd 12706 21 s s NN cord-010119-t1x9gknd 12706 22 201 201 CD cord-010119-t1x9gknd 12706 23 system system NN cord-010119-t1x9gknd 12706 24 and and CC cord-010119-t1x9gknd 12706 25 we -PRON- PRP cord-010119-t1x9gknd 12706 26 have have VBP cord-010119-t1x9gknd 12706 27 3 3 CD cord-010119-t1x9gknd 12706 28 technician technician NN cord-010119-t1x9gknd 12706 29 related relate VBN cord-010119-t1x9gknd 12706 30 failures failure NNS cord-010119-t1x9gknd 12706 31 per per IN cord-010119-t1x9gknd 12706 32 week week NN cord-010119-t1x9gknd 12706 33 . . . cord-010119-t1x9gknd 12707 1 A a DT cord-010119-t1x9gknd 12707 2 Lean Lean NNP cord-010119-t1x9gknd 12707 3 Six six CD cord-010119-t1x9gknd 12707 4 Sigma Sigma NNP cord-010119-t1x9gknd 12707 5 approach approach NN cord-010119-t1x9gknd 12707 6 for for IN cord-010119-t1x9gknd 12707 7 process process NN cord-010119-t1x9gknd 12707 8 improvement improvement NN cord-010119-t1x9gknd 12707 9 was be VBD cord-010119-t1x9gknd 12707 10 utilized utilize VBN cord-010119-t1x9gknd 12707 11 to to TO cord-010119-t1x9gknd 12707 12 identify identify VB cord-010119-t1x9gknd 12707 13 root root NN cord-010119-t1x9gknd 12707 14 causes cause NNS cord-010119-t1x9gknd 12707 15 and and CC cord-010119-t1x9gknd 12707 16 develop develop VB cord-010119-t1x9gknd 12707 17 countermeasures countermeasure NNS cord-010119-t1x9gknd 12707 18 in in IN cord-010119-t1x9gknd 12707 19 order order NN cord-010119-t1x9gknd 12707 20 to to TO cord-010119-t1x9gknd 12707 21 decrease decrease VB cord-010119-t1x9gknd 12707 22 the the DT cord-010119-t1x9gknd 12707 23 number number NN cord-010119-t1x9gknd 12707 24 of of IN cord-010119-t1x9gknd 12707 25 technician technician NN cord-010119-t1x9gknd 12707 26 related relate VBN cord-010119-t1x9gknd 12707 27 failures failure NNS cord-010119-t1x9gknd 12707 28 on on IN cord-010119-t1x9gknd 12707 29 the the DT cord-010119-t1x9gknd 12707 30 s s NN cord-010119-t1x9gknd 12707 31 201 201 CD cord-010119-t1x9gknd 12707 32 system system NN cord-010119-t1x9gknd 12707 33 . . . cord-010119-t1x9gknd 12708 1 Study Study NNP cord-010119-t1x9gknd 12708 2 Design Design NNP cord-010119-t1x9gknd 12708 3 / / SYM cord-010119-t1x9gknd 12708 4 Method method NN cord-010119-t1x9gknd 12708 5 : : : cord-010119-t1x9gknd 12709 1 The the DT cord-010119-t1x9gknd 12709 2 number number NN cord-010119-t1x9gknd 12709 3 of of IN cord-010119-t1x9gknd 12709 4 technician technician NN cord-010119-t1x9gknd 12709 5 related relate VBN cord-010119-t1x9gknd 12709 6 failed fail VBD cord-010119-t1x9gknd 12709 7 runs run NNS cord-010119-t1x9gknd 12709 8 on on IN cord-010119-t1x9gknd 12709 9 the the DT cord-010119-t1x9gknd 12709 10 s s NN cord-010119-t1x9gknd 12709 11 201 201 CD cord-010119-t1x9gknd 12709 12 system system NN cord-010119-t1x9gknd 12709 13 were be VBD cord-010119-t1x9gknd 12709 14 tracked track VBN cord-010119-t1x9gknd 12709 15 from from IN cord-010119-t1x9gknd 12709 16 10/11/2015 10/11/2015 CD cord-010119-t1x9gknd 12709 17 thru thru IN cord-010119-t1x9gknd 12709 18 12/11/2016 12/11/2016 CD cord-010119-t1x9gknd 12709 19 . . . cord-010119-t1x9gknd 12710 1 A a DT cord-010119-t1x9gknd 12710 2 Pareto Pareto NNP cord-010119-t1x9gknd 12710 3 chart chart NN cord-010119-t1x9gknd 12710 4 was be VBD cord-010119-t1x9gknd 12710 5 used use VBN cord-010119-t1x9gknd 12710 6 to to TO cord-010119-t1x9gknd 12710 7 determine determine VB cord-010119-t1x9gknd 12710 8 that that DT cord-010119-t1x9gknd 12710 9 technician technician NN cord-010119-t1x9gknd 12710 10 related related JJ cord-010119-t1x9gknd 12710 11 errors error NNS cord-010119-t1x9gknd 12710 12 was be VBD cord-010119-t1x9gknd 12710 13 the the DT cord-010119-t1x9gknd 12710 14 largest large JJS cord-010119-t1x9gknd 12710 15 controllable controllable JJ cord-010119-t1x9gknd 12710 16 factor factor NN cord-010119-t1x9gknd 12710 17 causing cause VBG cord-010119-t1x9gknd 12710 18 run run NN cord-010119-t1x9gknd 12710 19 failures failure NNS cord-010119-t1x9gknd 12710 20 . . . cord-010119-t1x9gknd 12711 1 The the DT cord-010119-t1x9gknd 12711 2 5 5 CD cord-010119-t1x9gknd 12711 3 Why why WRB cord-010119-t1x9gknd 12711 4 s s PRP cord-010119-t1x9gknd 12711 5 were be VBD cord-010119-t1x9gknd 12711 6 performed perform VBN cord-010119-t1x9gknd 12711 7 to to TO cord-010119-t1x9gknd 12711 8 determine determine VB cord-010119-t1x9gknd 12711 9 root root NN cord-010119-t1x9gknd 12711 10 causes cause NNS cord-010119-t1x9gknd 12711 11 of of IN cord-010119-t1x9gknd 12711 12 technician technician NN cord-010119-t1x9gknd 12711 13 related relate VBN cord-010119-t1x9gknd 12711 14 failed fail VBD cord-010119-t1x9gknd 12711 15 runs run NNS cord-010119-t1x9gknd 12711 16 . . . cord-010119-t1x9gknd 12712 1 A a DT cord-010119-t1x9gknd 12712 2 Gemba Gemba NNP cord-010119-t1x9gknd 12712 3 walk walk NN cord-010119-t1x9gknd 12712 4 was be VBD cord-010119-t1x9gknd 12712 5 performed perform VBN cord-010119-t1x9gknd 12712 6 on on IN cord-010119-t1x9gknd 12712 7 all all DT cord-010119-t1x9gknd 12712 8 of of IN cord-010119-t1x9gknd 12712 9 the the DT cord-010119-t1x9gknd 12712 10 lab lab NN cord-010119-t1x9gknd 12712 11 testing testing NN cord-010119-t1x9gknd 12712 12 processes process NNS cord-010119-t1x9gknd 12712 13 to to TO cord-010119-t1x9gknd 12712 14 help help VB cord-010119-t1x9gknd 12712 15 identify identify VB cord-010119-t1x9gknd 12712 16 areas area NNS cord-010119-t1x9gknd 12712 17 for for IN cord-010119-t1x9gknd 12712 18 improvement improvement NN cord-010119-t1x9gknd 12712 19 . . . cord-010119-t1x9gknd 12713 1 The the DT cord-010119-t1x9gknd 12713 2 process process NN cord-010119-t1x9gknd 12713 3 Improvement improvement NN cord-010119-t1x9gknd 12713 4 team team NN cord-010119-t1x9gknd 12713 5 talked talk VBD cord-010119-t1x9gknd 12713 6 , , , cord-010119-t1x9gknd 12713 7 met meet VBD cord-010119-t1x9gknd 12713 8 , , , cord-010119-t1x9gknd 12713 9 observed observe VBD cord-010119-t1x9gknd 12713 10 , , , cord-010119-t1x9gknd 12713 11 and and CC cord-010119-t1x9gknd 12713 12 worked work VBD cord-010119-t1x9gknd 12713 13 directly directly RB cord-010119-t1x9gknd 12713 14 with with IN cord-010119-t1x9gknd 12713 15 staff staff NN cord-010119-t1x9gknd 12713 16 that that WDT cord-010119-t1x9gknd 12713 17 operate operate VBP cord-010119-t1x9gknd 12713 18 the the DT cord-010119-t1x9gknd 12713 19 s s NN cord-010119-t1x9gknd 12713 20 201 201 CD cord-010119-t1x9gknd 12713 21 system system NN cord-010119-t1x9gknd 12713 22 . . . cord-010119-t1x9gknd 12714 1 Roche Roche NNP cord-010119-t1x9gknd 12714 2 was be VBD cord-010119-t1x9gknd 12714 3 also also RB cord-010119-t1x9gknd 12714 4 contacted contact VBN cord-010119-t1x9gknd 12714 5 to to TO cord-010119-t1x9gknd 12714 6 provide provide VB cord-010119-t1x9gknd 12714 7 guidance guidance NN cord-010119-t1x9gknd 12714 8 on on IN cord-010119-t1x9gknd 12714 9 how how WRB cord-010119-t1x9gknd 12714 10 to to TO cord-010119-t1x9gknd 12714 11 help help VB cord-010119-t1x9gknd 12714 12 decrease decrease VB cord-010119-t1x9gknd 12714 13 technician technician NN cord-010119-t1x9gknd 12714 14 related relate VBN cord-010119-t1x9gknd 12714 15 failures failure NNS cord-010119-t1x9gknd 12714 16 . . . cord-010119-t1x9gknd 12715 1 Results result NNS cord-010119-t1x9gknd 12715 2 / / SYM cord-010119-t1x9gknd 12715 3 Finding finding NN cord-010119-t1x9gknd 12715 4 : : : cord-010119-t1x9gknd 12716 1 The the DT cord-010119-t1x9gknd 12716 2 main main JJ cord-010119-t1x9gknd 12716 3 root root NN cord-010119-t1x9gknd 12716 4 cause cause NN cord-010119-t1x9gknd 12716 5 determined determine VBN cord-010119-t1x9gknd 12716 6 was be VBD cord-010119-t1x9gknd 12716 7 that that IN cord-010119-t1x9gknd 12716 8 there there EX cord-010119-t1x9gknd 12716 9 was be VBD cord-010119-t1x9gknd 12716 10 no no DT cord-010119-t1x9gknd 12716 11 current current JJ cord-010119-t1x9gknd 12716 12 process process NN cord-010119-t1x9gknd 12716 13 flow flow NN cord-010119-t1x9gknd 12716 14 map map NN cord-010119-t1x9gknd 12716 15 for for IN cord-010119-t1x9gknd 12716 16 whole whole JJ cord-010119-t1x9gknd 12716 17 blood blood NN cord-010119-t1x9gknd 12716 18 donor donor NN cord-010119-t1x9gknd 12716 19 testing testing NN cord-010119-t1x9gknd 12716 20 using use VBG cord-010119-t1x9gknd 12716 21 the the DT cord-010119-t1x9gknd 12716 22 s s NNP cord-010119-t1x9gknd 12716 23 201 201 CD cord-010119-t1x9gknd 12716 24 system system NN cord-010119-t1x9gknd 12716 25 . . . cord-010119-t1x9gknd 12717 1 Counter counter NN cord-010119-t1x9gknd 12717 2 measures measure NNS cord-010119-t1x9gknd 12717 3 implemented implement VBD cord-010119-t1x9gknd 12717 4 included include VBD cord-010119-t1x9gknd 12717 5 creating create VBG cord-010119-t1x9gknd 12717 6 a a DT cord-010119-t1x9gknd 12717 7 two two CD cord-010119-t1x9gknd 12717 8 phase phase NN cord-010119-t1x9gknd 12717 9 process process NN cord-010119-t1x9gknd 12717 10 map map NN cord-010119-t1x9gknd 12717 11 . . . cord-010119-t1x9gknd 12718 1 One one CD cord-010119-t1x9gknd 12718 2 phase phase NN cord-010119-t1x9gknd 12718 3 was be VBD cord-010119-t1x9gknd 12718 4 related relate VBN cord-010119-t1x9gknd 12718 5 to to IN cord-010119-t1x9gknd 12718 6 the the DT cord-010119-t1x9gknd 12718 7 processes process NNS cord-010119-t1x9gknd 12718 8 related relate VBN cord-010119-t1x9gknd 12718 9 to to TO cord-010119-t1x9gknd 12718 10 start start VB cord-010119-t1x9gknd 12718 11 - - HYPH cord-010119-t1x9gknd 12718 12 up up NN cord-010119-t1x9gknd 12718 13 of of IN cord-010119-t1x9gknd 12718 14 the the DT cord-010119-t1x9gknd 12718 15 system system NN cord-010119-t1x9gknd 12718 16 and and CC cord-010119-t1x9gknd 12718 17 the the DT cord-010119-t1x9gknd 12718 18 second second JJ cord-010119-t1x9gknd 12718 19 phase phase NN cord-010119-t1x9gknd 12718 20 was be VBD cord-010119-t1x9gknd 12718 21 related relate VBN cord-010119-t1x9gknd 12718 22 to to IN cord-010119-t1x9gknd 12718 23 the the DT cord-010119-t1x9gknd 12718 24 processes process NNS cord-010119-t1x9gknd 12718 25 involved involve VBN cord-010119-t1x9gknd 12718 26 in in IN cord-010119-t1x9gknd 12718 27 processing processing NN cord-010119-t1x9gknd 12718 28 of of IN cord-010119-t1x9gknd 12718 29 samples sample NNS cord-010119-t1x9gknd 12718 30 . . . cord-010119-t1x9gknd 12719 1 Roche Roche NNP cord-010119-t1x9gknd 12719 2 provided provide VBD cord-010119-t1x9gknd 12719 3 a a DT cord-010119-t1x9gknd 12719 4 job job NN cord-010119-t1x9gknd 12719 5 aid aid NN cord-010119-t1x9gknd 12719 6 for for IN cord-010119-t1x9gknd 12719 7 the the DT cord-010119-t1x9gknd 12719 8 technicians technician NNS cord-010119-t1x9gknd 12719 9 which which WDT cord-010119-t1x9gknd 12719 10 provides provide VBZ cord-010119-t1x9gknd 12719 11 clear clear JJ cord-010119-t1x9gknd 12719 12 steps step NNS cord-010119-t1x9gknd 12719 13 technicians technician NNS cord-010119-t1x9gknd 12719 14 should should MD cord-010119-t1x9gknd 12719 15 take take VB cord-010119-t1x9gknd 12719 16 when when WRB cord-010119-t1x9gknd 12719 17 handling handle VBG cord-010119-t1x9gknd 12719 18 and and CC cord-010119-t1x9gknd 12719 19 cleaning clean VBG cord-010119-t1x9gknd 12719 20 up up RP cord-010119-t1x9gknd 12719 21 crashes crash NNS cord-010119-t1x9gknd 12719 22 and and CC cord-010119-t1x9gknd 12719 23 failed fail VBD cord-010119-t1x9gknd 12719 24 runs run NNS cord-010119-t1x9gknd 12719 25 on on IN cord-010119-t1x9gknd 12719 26 the the DT cord-010119-t1x9gknd 12719 27 s s NN cord-010119-t1x9gknd 12719 28 201 201 CD cord-010119-t1x9gknd 12719 29 system system NN cord-010119-t1x9gknd 12719 30 . . . cord-010119-t1x9gknd 12720 1 After after IN cord-010119-t1x9gknd 12720 2 counter counter NN cord-010119-t1x9gknd 12720 3 measures measure NNS cord-010119-t1x9gknd 12720 4 were be VBD cord-010119-t1x9gknd 12720 5 implemented implement VBN cord-010119-t1x9gknd 12720 6 , , , cord-010119-t1x9gknd 12720 7 the the DT cord-010119-t1x9gknd 12720 8 number number NN cord-010119-t1x9gknd 12720 9 of of IN cord-010119-t1x9gknd 12720 10 technician technician NN cord-010119-t1x9gknd 12720 11 related relate VBN cord-010119-t1x9gknd 12720 12 failed fail VBD cord-010119-t1x9gknd 12720 13 runs run NNS cord-010119-t1x9gknd 12720 14 decreased decrease VBD cord-010119-t1x9gknd 12720 15 from from IN cord-010119-t1x9gknd 12720 16 3 3 CD cord-010119-t1x9gknd 12720 17 to to TO cord-010119-t1x9gknd 12720 18 1.2 1.2 CD cord-010119-t1x9gknd 12720 19 failures failure NNS cord-010119-t1x9gknd 12720 20 per per IN cord-010119-t1x9gknd 12720 21 week week NN cord-010119-t1x9gknd 12720 22 , , , cord-010119-t1x9gknd 12720 23 which which WDT cord-010119-t1x9gknd 12720 24 was be VBD cord-010119-t1x9gknd 12720 25 a a DT cord-010119-t1x9gknd 12720 26 58 58 CD cord-010119-t1x9gknd 12720 27 % % NN cord-010119-t1x9gknd 12720 28 decrease decrease NN cord-010119-t1x9gknd 12720 29 . . . cord-010119-t1x9gknd 12721 1 Conclusion conclusion NN cord-010119-t1x9gknd 12721 2 : : : cord-010119-t1x9gknd 12722 1 A a DT cord-010119-t1x9gknd 12722 2 Lean Lean NNP cord-010119-t1x9gknd 12722 3 Six six CD cord-010119-t1x9gknd 12722 4 Sigma Sigma NNP cord-010119-t1x9gknd 12722 5 approach approach NN cord-010119-t1x9gknd 12722 6 for for IN cord-010119-t1x9gknd 12722 7 process process NN cord-010119-t1x9gknd 12722 8 improvement improvement NN cord-010119-t1x9gknd 12722 9 was be VBD cord-010119-t1x9gknd 12722 10 utilized utilize VBN cord-010119-t1x9gknd 12722 11 to to TO cord-010119-t1x9gknd 12722 12 identify identify VB cord-010119-t1x9gknd 12722 13 root root NN cord-010119-t1x9gknd 12722 14 causes cause NNS cord-010119-t1x9gknd 12722 15 and and CC cord-010119-t1x9gknd 12722 16 develop develop VB cord-010119-t1x9gknd 12722 17 countermeasures countermeasure NNS cord-010119-t1x9gknd 12722 18 in in IN cord-010119-t1x9gknd 12722 19 order order NN cord-010119-t1x9gknd 12722 20 to to TO cord-010119-t1x9gknd 12722 21 decrease decrease VB cord-010119-t1x9gknd 12722 22 the the DT cord-010119-t1x9gknd 12722 23 number number NN cord-010119-t1x9gknd 12722 24 of of IN cord-010119-t1x9gknd 12722 25 technician technician NN cord-010119-t1x9gknd 12722 26 related relate VBN cord-010119-t1x9gknd 12722 27 failed fail VBD cord-010119-t1x9gknd 12722 28 runs run NNS cord-010119-t1x9gknd 12722 29 on on IN cord-010119-t1x9gknd 12722 30 the the DT cord-010119-t1x9gknd 12722 31 cobas cobas NNP cord-010119-t1x9gknd 12722 32 s s POS cord-010119-t1x9gknd 12722 33 201 201 CD cord-010119-t1x9gknd 12722 34 system system NN cord-010119-t1x9gknd 12722 35 . . . cord-010119-t1x9gknd 12723 1 This this DT cord-010119-t1x9gknd 12723 2 lean lean JJ cord-010119-t1x9gknd 12723 3 six six CD cord-010119-t1x9gknd 12723 4 sigma sigma NN cord-010119-t1x9gknd 12723 5 approach approach NN cord-010119-t1x9gknd 12723 6 and and CC cord-010119-t1x9gknd 12723 7 counter counter NN cord-010119-t1x9gknd 12723 8 measures measure NNS cord-010119-t1x9gknd 12723 9 significantly significantly RB cord-010119-t1x9gknd 12723 10 decreased decrease VBD cord-010119-t1x9gknd 12723 11 the the DT cord-010119-t1x9gknd 12723 12 number number NN cord-010119-t1x9gknd 12723 13 of of IN cord-010119-t1x9gknd 12723 14 technician technician NN cord-010119-t1x9gknd 12723 15 related relate VBN cord-010119-t1x9gknd 12723 16 failed fail VBD cord-010119-t1x9gknd 12723 17 runs run NNS cord-010119-t1x9gknd 12723 18 by by IN cord-010119-t1x9gknd 12723 19 58 58 CD cord-010119-t1x9gknd 12723 20 % % NN cord-010119-t1x9gknd 12723 21 . . . cord-010119-t1x9gknd 12724 1 patients patient NNS cord-010119-t1x9gknd 12724 2 who who WP cord-010119-t1x9gknd 12724 3 were be VBD cord-010119-t1x9gknd 12724 4 transfused transfuse VBN cord-010119-t1x9gknd 12724 5 for for IN cord-010119-t1x9gknd 12724 6 pre pre JJ cord-010119-t1x9gknd 12724 7 - - JJ cord-010119-t1x9gknd 12724 8 transfusion transfusion JJ cord-010119-t1x9gknd 12724 9 hgb hgb NNP cord-010119-t1x9gknd 12724 10 > > XX cord-010119-t1x9gknd 12724 11 7g 7g NNP cord-010119-t1x9gknd 12724 12 / / SYM cord-010119-t1x9gknd 12724 13 dl dl NN cord-010119-t1x9gknd 12724 14 with with IN cord-010119-t1x9gknd 12724 15 resulting result VBG cord-010119-t1x9gknd 12724 16 post post JJ cord-010119-t1x9gknd 12724 17 - - JJ cord-010119-t1x9gknd 12724 18 transfusion transfusion NN cord-010119-t1x9gknd 12724 19 hgb hgb NNP cord-010119-t1x9gknd 12725 1 > > XX cord-010119-t1x9gknd 12726 1 9g 9g NNP cord-010119-t1x9gknd 12726 2 / / SYM cord-010119-t1x9gknd 12726 3 dl dl NNP cord-010119-t1x9gknd 12726 4 were be VBD cord-010119-t1x9gknd 12726 5 reviewed review VBN cord-010119-t1x9gknd 12726 6 . . . cord-010119-t1x9gknd 12727 1 Demographics demographic NNS cord-010119-t1x9gknd 12727 2 , , , cord-010119-t1x9gknd 12727 3 medical medical JJ cord-010119-t1x9gknd 12727 4 history history NN cord-010119-t1x9gknd 12727 5 , , , cord-010119-t1x9gknd 12727 6 provider provider NN cord-010119-t1x9gknd 12727 7 identity identity NN cord-010119-t1x9gknd 12727 8 , , , cord-010119-t1x9gknd 12727 9 indication indication NN cord-010119-t1x9gknd 12727 10 and and CC cord-010119-t1x9gknd 12727 11 transfusion transfusion NN cord-010119-t1x9gknd 12727 12 complications complication NNS cord-010119-t1x9gknd 12727 13 were be VBD cord-010119-t1x9gknd 12727 14 abstracted abstract VBN cord-010119-t1x9gknd 12727 15 & & CC cord-010119-t1x9gknd 12727 16 compiled compile VBN cord-010119-t1x9gknd 12727 17 individually individually RB cord-010119-t1x9gknd 12727 18 by by IN cord-010119-t1x9gknd 12727 19 11 11 CD cord-010119-t1x9gknd 12727 20 volunteer volunteer NN cord-010119-t1x9gknd 12727 21 internal internal JJ cord-010119-t1x9gknd 12727 22 medicine medicine NN cord-010119-t1x9gknd 12727 23 residents resident NNS cord-010119-t1x9gknd 12727 24 . . . cord-010119-t1x9gknd 12728 1 Group group NN cord-010119-t1x9gknd 12728 2 discussion discussion NN cord-010119-t1x9gknd 12728 3 for for IN cord-010119-t1x9gknd 12728 4 each each DT cord-010119-t1x9gknd 12728 5 case case NN cord-010119-t1x9gknd 12728 6 ensued ensue VBD cord-010119-t1x9gknd 12728 7 before before IN cord-010119-t1x9gknd 12728 8 determination determination NN cord-010119-t1x9gknd 12728 9 of of IN cord-010119-t1x9gknd 12728 10 transfusion transfusion NN cord-010119-t1x9gknd 12728 11 appropriateness appropriateness NN cord-010119-t1x9gknd 12728 12 occurred occur VBD cord-010119-t1x9gknd 12728 13 . . . cord-010119-t1x9gknd 12729 1 Principal principal JJ cord-010119-t1x9gknd 12729 2 investigator investigator NN cord-010119-t1x9gknd 12729 3 / / SYM cord-010119-t1x9gknd 12729 4 attending attend VBG cord-010119-t1x9gknd 12729 5 physician physician NN cord-010119-t1x9gknd 12729 6 then then RB cord-010119-t1x9gknd 12729 7 made make VBD cord-010119-t1x9gknd 12729 8 final final JJ cord-010119-t1x9gknd 12729 9 determination determination NN cord-010119-t1x9gknd 12729 10 of of IN cord-010119-t1x9gknd 12729 11 appropriateness appropriateness NN cord-010119-t1x9gknd 12729 12 of of IN cord-010119-t1x9gknd 12729 13 RBC RBC NNP cord-010119-t1x9gknd 12729 14 transfusion transfusion NN cord-010119-t1x9gknd 12729 15 . . . cord-010119-t1x9gknd 12730 1 Results/ Results/ . cord-010119-t1x9gknd 12731 1 Finding finding NN cord-010119-t1x9gknd 12731 2 : : : cord-010119-t1x9gknd 12731 3 265 265 CD cord-010119-t1x9gknd 12731 4 patient patient NN cord-010119-t1x9gknd 12731 5 charts chart NNS cord-010119-t1x9gknd 12731 6 were be VBD cord-010119-t1x9gknd 12731 7 reviewed review VBN cord-010119-t1x9gknd 12731 8 . . . cord-010119-t1x9gknd 12732 1 91 91 CD cord-010119-t1x9gknd 12732 2 were be VBD cord-010119-t1x9gknd 12732 3 excluded exclude VBN cord-010119-t1x9gknd 12732 4 for for IN cord-010119-t1x9gknd 12732 5 bleeding bleed VBG cord-010119-t1x9gknd 12732 6 and and CC cord-010119-t1x9gknd 12732 7 cardiovascular cardiovascular JJ cord-010119-t1x9gknd 12732 8 instability instability NN cord-010119-t1x9gknd 12732 9 . . . cord-010119-t1x9gknd 12733 1 106/174 106/174 LS cord-010119-t1x9gknd 12733 2 ( ( -LRB- cord-010119-t1x9gknd 12733 3 60.9 60.9 CD cord-010119-t1x9gknd 12733 4 % % NN cord-010119-t1x9gknd 12733 5 ) ) -RRB- cord-010119-t1x9gknd 12733 6 were be VBD cord-010119-t1x9gknd 12733 7 determined determine VBN cord-010119-t1x9gknd 12733 8 to to TO cord-010119-t1x9gknd 12733 9 be be VB cord-010119-t1x9gknd 12733 10 transfused transfuse VBN cord-010119-t1x9gknd 12733 11 inappropriately inappropriately RB cord-010119-t1x9gknd 12733 12 . . . cord-010119-t1x9gknd 12734 1 There there EX cord-010119-t1x9gknd 12734 2 was be VBD cord-010119-t1x9gknd 12734 3 no no DT cord-010119-t1x9gknd 12734 4 difference difference NN cord-010119-t1x9gknd 12734 5 in in IN cord-010119-t1x9gknd 12734 6 appropriateness appropriateness NN cord-010119-t1x9gknd 12734 7 of of IN cord-010119-t1x9gknd 12734 8 transfusion transfusion NN cord-010119-t1x9gknd 12734 9 with with IN cord-010119-t1x9gknd 12734 10 respect respect NN cord-010119-t1x9gknd 12734 11 to to IN cord-010119-t1x9gknd 12734 12 age age NN cord-010119-t1x9gknd 12734 13 or or CC cord-010119-t1x9gknd 12734 14 sex sex NN cord-010119-t1x9gknd 12734 15 . . . cord-010119-t1x9gknd 12735 1 Patients patient NNS cord-010119-t1x9gknd 12735 2 with with IN cord-010119-t1x9gknd 12735 3 solid solid JJ cord-010119-t1x9gknd 12735 4 tumors tumor NNS cord-010119-t1x9gknd 12735 5 ( ( -LRB- cord-010119-t1x9gknd 12735 6 76.19 76.19 CD cord-010119-t1x9gknd 12735 7 % % NN cord-010119-t1x9gknd 12735 8 vs vs IN cord-010119-t1x9gknd 12735 9 55.73 55.73 CD cord-010119-t1x9gknd 12735 10 % % NN cord-010119-t1x9gknd 12735 11 , , , cord-010119-t1x9gknd 12735 12 p50.0181 p50.0181 NN cord-010119-t1x9gknd 12735 13 ) ) -RRB- cord-010119-t1x9gknd 12735 14 and and CC cord-010119-t1x9gknd 12735 15 anemia anemia NN cord-010119-t1x9gknd 12735 16 of of IN cord-010119-t1x9gknd 12735 17 chronic chronic JJ cord-010119-t1x9gknd 12735 18 disease disease NN cord-010119-t1x9gknd 12735 19 ( ( -LRB- cord-010119-t1x9gknd 12735 20 76.47 76.47 CD cord-010119-t1x9gknd 12735 21 % % NN cord-010119-t1x9gknd 12735 22 vs vs IN cord-010119-t1x9gknd 12735 23 54.1 54.1 CD cord-010119-t1x9gknd 12735 24 % % NN cord-010119-t1x9gknd 12735 25 , , , cord-010119-t1x9gknd 12735 26 p50.006 p50.006 NNP cord-010119-t1x9gknd 12735 27 ) ) -RRB- cord-010119-t1x9gknd 12735 28 were be VBD cord-010119-t1x9gknd 12735 29 more more RBR cord-010119-t1x9gknd 12735 30 likely likely JJ cord-010119-t1x9gknd 12735 31 to to TO cord-010119-t1x9gknd 12735 32 be be VB cord-010119-t1x9gknd 12735 33 inappropriately inappropriately RB cord-010119-t1x9gknd 12735 34 transfused transfuse VBN cord-010119-t1x9gknd 12735 35 . . . cord-010119-t1x9gknd 12736 1 Patients patient NNS cord-010119-t1x9gknd 12736 2 who who WP cord-010119-t1x9gknd 12736 3 had have VBD cord-010119-t1x9gknd 12736 4 higher high JJR cord-010119-t1x9gknd 12736 5 pre pre JJ cord-010119-t1x9gknd 12736 6 - - JJ cord-010119-t1x9gknd 12736 7 transfusion transfusion JJ cord-010119-t1x9gknd 12736 8 hemoglobin hemoglobin NN cord-010119-t1x9gknd 12736 9 were be VBD cord-010119-t1x9gknd 12736 10 more more RBR cord-010119-t1x9gknd 12736 11 likely likely JJ cord-010119-t1x9gknd 12736 12 to to TO cord-010119-t1x9gknd 12736 13 be be VB cord-010119-t1x9gknd 12736 14 inappropriately inappropriately RB cord-010119-t1x9gknd 12736 15 transfused transfuse VBN cord-010119-t1x9gknd 12736 16 ( ( -LRB- cord-010119-t1x9gknd 12736 17 median median JJ cord-010119-t1x9gknd 12736 18 hgb hgb NNP cord-010119-t1x9gknd 12736 19 7.7 7.7 CD cord-010119-t1x9gknd 12736 20 g g NN cord-010119-t1x9gknd 12736 21 / / SYM cord-010119-t1x9gknd 12736 22 dL dl NN cord-010119-t1x9gknd 12737 1 vs vs IN cord-010119-t1x9gknd 12737 2 7.3 7.3 CD cord-010119-t1x9gknd 12737 3 g g NN cord-010119-t1x9gknd 12737 4 / / SYM cord-010119-t1x9gknd 12737 5 dL dl NN cord-010119-t1x9gknd 12737 6 , , , cord-010119-t1x9gknd 12737 7 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 12737 8 ) ) -RRB- cord-010119-t1x9gknd 12737 9 . . . cord-010119-t1x9gknd 12738 1 Inappropriately inappropriately RB cord-010119-t1x9gknd 12738 2 transfused transfuse VBN cord-010119-t1x9gknd 12738 3 patients patient NNS cord-010119-t1x9gknd 12738 4 also also RB cord-010119-t1x9gknd 12738 5 had have VBD cord-010119-t1x9gknd 12738 6 higher high JJR cord-010119-t1x9gknd 12738 7 median median JJ cord-010119-t1x9gknd 12738 8 post post JJ cord-010119-t1x9gknd 12738 9 - - JJ cord-010119-t1x9gknd 12738 10 transfusion transfusion JJ cord-010119-t1x9gknd 12738 11 hemoglobin hemoglobin NN cord-010119-t1x9gknd 12738 12 ( ( -LRB- cord-010119-t1x9gknd 12738 13 9.9 9.9 CD cord-010119-t1x9gknd 12738 14 g g NN cord-010119-t1x9gknd 12738 15 / / SYM cord-010119-t1x9gknd 12738 16 dL dl NN cord-010119-t1x9gknd 12738 17 vs vs IN cord-010119-t1x9gknd 12738 18 9.4 9.4 CD cord-010119-t1x9gknd 12738 19 g g NN cord-010119-t1x9gknd 12738 20 / / SYM cord-010119-t1x9gknd 12738 21 dL dl NN cord-010119-t1x9gknd 12738 22 , , , cord-010119-t1x9gknd 12738 23 p<0.0001 p<0.0001 NNP cord-010119-t1x9gknd 12738 24 ) ) -RRB- cord-010119-t1x9gknd 12738 25 . . . cord-010119-t1x9gknd 12739 1 Moreover moreover RB cord-010119-t1x9gknd 12739 2 , , , cord-010119-t1x9gknd 12739 3 lab lab NN cord-010119-t1x9gknd 12739 4 evalutions evalution NNS cord-010119-t1x9gknd 12739 5 revealed reveal VBD cord-010119-t1x9gknd 12739 6 association association NN cord-010119-t1x9gknd 12739 7 with with IN cord-010119-t1x9gknd 12739 8 lower low JJR cord-010119-t1x9gknd 12739 9 folate folate NN cord-010119-t1x9gknd 12739 10 levels level NNS cord-010119-t1x9gknd 12739 11 ( ( -LRB- cord-010119-t1x9gknd 12739 12 median median NN cord-010119-t1x9gknd 12739 13 8.1 8.1 CD cord-010119-t1x9gknd 12739 14 nmol nmol JJ cord-010119-t1x9gknd 12739 15 / / SYM cord-010119-t1x9gknd 12739 16 L l NN cord-010119-t1x9gknd 12739 17 vs vs IN cord-010119-t1x9gknd 12739 18 15.7 15.7 CD cord-010119-t1x9gknd 12739 19 nmol nmol NNP cord-010119-t1x9gknd 12739 20 / / SYM cord-010119-t1x9gknd 12739 21 L L NNP cord-010119-t1x9gknd 12739 22 , , , cord-010119-t1x9gknd 12739 23 p50.029 p50.029 NN cord-010119-t1x9gknd 12739 24 ) ) -RRB- cord-010119-t1x9gknd 12739 25 . . . cord-010119-t1x9gknd 12740 1 29/106 29/106 CD cord-010119-t1x9gknd 12740 2 ( ( -LRB- cord-010119-t1x9gknd 12740 3 27.3 27.3 CD cord-010119-t1x9gknd 12740 4 % % NN cord-010119-t1x9gknd 12740 5 ) ) -RRB- cord-010119-t1x9gknd 12741 1 patients patient NNS cord-010119-t1x9gknd 12741 2 were be VBD cord-010119-t1x9gknd 12741 3 inappropriately inappropriately RB cord-010119-t1x9gknd 12741 4 transfused transfuse VBN cord-010119-t1x9gknd 12741 5 at at IN cord-010119-t1x9gknd 12741 6 least least JJS cord-010119-t1x9gknd 12741 7 in in IN cord-010119-t1x9gknd 12741 8 part part NN cord-010119-t1x9gknd 12741 9 because because IN cord-010119-t1x9gknd 12741 10 they -PRON- PRP cord-010119-t1x9gknd 12741 11 received receive VBD cord-010119-t1x9gknd 12741 12 more more JJR cord-010119-t1x9gknd 12741 13 than than IN cord-010119-t1x9gknd 12741 14 one one CD cord-010119-t1x9gknd 12741 15 unit unit NN cord-010119-t1x9gknd 12741 16 without without IN cord-010119-t1x9gknd 12741 17 an an DT cord-010119-t1x9gknd 12741 18 interval interval NN cord-010119-t1x9gknd 12741 19 hemoglobin hemoglobin NN cord-010119-t1x9gknd 12741 20 check check NN cord-010119-t1x9gknd 12741 21 in in RP cord-010119-t1x9gknd 12741 22 between between IN cord-010119-t1x9gknd 12741 23 . . . cord-010119-t1x9gknd 12742 1 7/64 7/64 CD cord-010119-t1x9gknd 12742 2 providers provider NNS cord-010119-t1x9gknd 12742 3 were be VBD cord-010119-t1x9gknd 12742 4 responsible responsible JJ cord-010119-t1x9gknd 12742 5 for for IN cord-010119-t1x9gknd 12742 6 32.3 32.3 CD cord-010119-t1x9gknd 12742 7 % % NN cord-010119-t1x9gknd 12742 8 of of IN cord-010119-t1x9gknd 12742 9 all all DT cord-010119-t1x9gknd 12742 10 inappropriate inappropriate JJ cord-010119-t1x9gknd 12742 11 transfusions transfusion NNS cord-010119-t1x9gknd 12742 12 . . . cord-010119-t1x9gknd 12743 1 1/68 1/68 CD cord-010119-t1x9gknd 12743 2 appropriately appropriately RB cord-010119-t1x9gknd 12743 3 - - HYPH cord-010119-t1x9gknd 12743 4 transfused transfuse VBN cord-010119-t1x9gknd 12743 5 patients patient NNS cord-010119-t1x9gknd 12743 6 experienced experience VBD cord-010119-t1x9gknd 12743 7 an an DT cord-010119-t1x9gknd 12743 8 FNHTR fnhtr NN cord-010119-t1x9gknd 12743 9 . . . cord-010119-t1x9gknd 12744 1 3 3 CD cord-010119-t1x9gknd 12744 2 deaths death NNS cord-010119-t1x9gknd 12744 3 unrelated unrelated JJ cord-010119-t1x9gknd 12744 4 to to IN cord-010119-t1x9gknd 12744 5 transfusion transfusion NN cord-010119-t1x9gknd 12744 6 occurred occur VBD cord-010119-t1x9gknd 12744 7 ( ( -LRB- cord-010119-t1x9gknd 12744 8 1 1 CD cord-010119-t1x9gknd 12744 9 in in IN cord-010119-t1x9gknd 12744 10 appropriate appropriate JJ cord-010119-t1x9gknd 12744 11 , , , cord-010119-t1x9gknd 12744 12 2 2 CD cord-010119-t1x9gknd 12744 13 in in IN cord-010119-t1x9gknd 12744 14 inappropriate inappropriate JJ cord-010119-t1x9gknd 12744 15 group group NN cord-010119-t1x9gknd 12744 16 ) ) -RRB- cord-010119-t1x9gknd 12744 17 . . . cord-010119-t1x9gknd 12745 1 Conclusion conclusion NN cord-010119-t1x9gknd 12745 2 : : : cord-010119-t1x9gknd 12746 1 Physicians physician NNS cord-010119-t1x9gknd 12746 2 in in IN cord-010119-t1x9gknd 12746 3 training training NN cord-010119-t1x9gknd 12746 4 are be VBP cord-010119-t1x9gknd 12746 5 interested interested JJ cord-010119-t1x9gknd 12746 6 in in IN cord-010119-t1x9gknd 12746 7 promulgating promulgate VBG cord-010119-t1x9gknd 12746 8 optimal optimal JJ cord-010119-t1x9gknd 12746 9 RBC RBC NNP cord-010119-t1x9gknd 12746 10 transfusion transfusion NN cord-010119-t1x9gknd 12746 11 practice practice NN cord-010119-t1x9gknd 12746 12 . . . cord-010119-t1x9gknd 12747 1 This this DT cord-010119-t1x9gknd 12747 2 study study NN cord-010119-t1x9gknd 12747 3 identified identify VBD cord-010119-t1x9gknd 12747 4 patient patient NN cord-010119-t1x9gknd 12747 5 factors factor NNS cord-010119-t1x9gknd 12747 6 ( ( -LRB- cord-010119-t1x9gknd 12747 7 such such JJ cord-010119-t1x9gknd 12747 8 as as IN cord-010119-t1x9gknd 12747 9 solid solid JJ cord-010119-t1x9gknd 12747 10 tumors tumor NNS cord-010119-t1x9gknd 12747 11 and and CC cord-010119-t1x9gknd 12747 12 anemia anemia NN cord-010119-t1x9gknd 12747 13 of of IN cord-010119-t1x9gknd 12747 14 chronic chronic JJ cord-010119-t1x9gknd 12747 15 disease disease NN cord-010119-t1x9gknd 12747 16 ) ) -RRB- cord-010119-t1x9gknd 12747 17 that that WDT cord-010119-t1x9gknd 12747 18 correlate correlate VBP cord-010119-t1x9gknd 12747 19 with with IN cord-010119-t1x9gknd 12747 20 a a DT cord-010119-t1x9gknd 12747 21 higher high JJR cord-010119-t1x9gknd 12747 22 likelihood likelihood NN cord-010119-t1x9gknd 12747 23 of of IN cord-010119-t1x9gknd 12747 24 receiving receive VBG cord-010119-t1x9gknd 12747 25 an an DT cord-010119-t1x9gknd 12747 26 inappropriate inappropriate JJ cord-010119-t1x9gknd 12747 27 transfusion transfusion NN cord-010119-t1x9gknd 12747 28 . . . cord-010119-t1x9gknd 12748 1 Beyond beyond IN cord-010119-t1x9gknd 12748 2 CPOE CPOE NNP cord-010119-t1x9gknd 12748 3 , , , cord-010119-t1x9gknd 12748 4 educational educational JJ cord-010119-t1x9gknd 12748 5 intervention intervention NN cord-010119-t1x9gknd 12748 6 at at IN cord-010119-t1x9gknd 12748 7 individual individual JJ cord-010119-t1x9gknd 12748 8 level level NN cord-010119-t1x9gknd 12748 9 should should MD cord-010119-t1x9gknd 12748 10 be be VB cord-010119-t1x9gknd 12748 11 designed design VBN cord-010119-t1x9gknd 12748 12 for for IN cord-010119-t1x9gknd 12748 13 specific specific JJ cord-010119-t1x9gknd 12748 14 providers provider NNS cord-010119-t1x9gknd 12748 15 responsible responsible JJ cord-010119-t1x9gknd 12748 16 for for IN cord-010119-t1x9gknd 12748 17 more more JJR cord-010119-t1x9gknd 12748 18 inappropriate inappropriate JJ cord-010119-t1x9gknd 12748 19 transfusions transfusion NNS cord-010119-t1x9gknd 12748 20 . . . cord-010119-t1x9gknd 12749 1 Successful successful JJ cord-010119-t1x9gknd 12749 2 Implementation implementation NN cord-010119-t1x9gknd 12749 3 of of IN cord-010119-t1x9gknd 12749 4 a a DT cord-010119-t1x9gknd 12749 5 Blood Blood NNP cord-010119-t1x9gknd 12749 6 Bank Bank NNP cord-010119-t1x9gknd 12749 7 Information Information NNP cord-010119-t1x9gknd 12749 8 System System NNP cord-010119-t1x9gknd 12749 9 in in IN cord-010119-t1x9gknd 12749 10 a a DT cord-010119-t1x9gknd 12749 11 Small small JJ cord-010119-t1x9gknd 12749 12 - - HYPH cord-010119-t1x9gknd 12749 13 Scale scale NN cord-010119-t1x9gknd 12749 14 Caribbean Caribbean NNP cord-010119-t1x9gknd 12749 15 Blood Blood NNP cord-010119-t1x9gknd 12749 16 Bank Bank NNP cord-010119-t1x9gknd 12749 17 : : : cord-010119-t1x9gknd 12750 1 A a DT cord-010119-t1x9gknd 12750 2 Structured structured JJ cord-010119-t1x9gknd 12750 3 Step Step NNP cord-010119-t1x9gknd 12750 4 - - : cord-010119-t1x9gknd 12750 5 Wise Wise NNP cord-010119-t1x9gknd 12750 6 Approach Approach NNP cord-010119-t1x9gknd 12750 7 . . . cord-010119-t1x9gknd 12751 1 Luigi Luigi NNP cord-010119-t1x9gknd 12751 2 Sille Sille NNP cord-010119-t1x9gknd 12751 3 * * NFP cord-010119-t1x9gknd 12751 4 1 1 CD cord-010119-t1x9gknd 12751 5 , , , cord-010119-t1x9gknd 12751 6 Willem Willem NNP cord-010119-t1x9gknd 12751 7 Martin Martin NNP cord-010119-t1x9gknd 12751 8 Smid Smid NNP cord-010119-t1x9gknd 12751 9 2 2 CD cord-010119-t1x9gknd 12751 10 and and CC cord-010119-t1x9gknd 12751 11 Ashley Ashley NNP cord-010119-t1x9gknd 12751 12 John John NNP cord-010119-t1x9gknd 12751 13 Duits Duits NNP cord-010119-t1x9gknd 12751 14 1 1 CD cord-010119-t1x9gknd 12751 15 . . . cord-010119-t1x9gknd 12751 16 1 1 CD cord-010119-t1x9gknd 12751 17 Red Red NNP cord-010119-t1x9gknd 12751 18 Cross Cross NNP cord-010119-t1x9gknd 12751 19 Blood Blood NNP cord-010119-t1x9gknd 12751 20 Bank Bank NNP cord-010119-t1x9gknd 12751 21 Foundation Foundation NNP cord-010119-t1x9gknd 12751 22 , , , cord-010119-t1x9gknd 12751 23 2 2 CD cord-010119-t1x9gknd 12751 24 Sanquin Sanquin NNP cord-010119-t1x9gknd 12751 25 Consulting Consulting NNP cord-010119-t1x9gknd 12751 26 Services Services NNPS cord-010119-t1x9gknd 12751 27 Background Background NNP cord-010119-t1x9gknd 12751 28 / / SYM cord-010119-t1x9gknd 12751 29 Case Case NNP cord-010119-t1x9gknd 12751 30 Studies Studies NNPS cord-010119-t1x9gknd 12751 31 : : : cord-010119-t1x9gknd 12752 1 An an DT cord-010119-t1x9gknd 12752 2 important important JJ cord-010119-t1x9gknd 12752 3 tool tool NN cord-010119-t1x9gknd 12752 4 for for IN cord-010119-t1x9gknd 12752 5 complying comply VBG cord-010119-t1x9gknd 12752 6 with with IN cord-010119-t1x9gknd 12752 7 GMP GMP NNP cord-010119-t1x9gknd 12752 8 quality quality NN cord-010119-t1x9gknd 12752 9 standards standard NNS cord-010119-t1x9gknd 12752 10 is be VBZ cord-010119-t1x9gknd 12752 11 the the DT cord-010119-t1x9gknd 12752 12 effective effective JJ cord-010119-t1x9gknd 12752 13 use use NN cord-010119-t1x9gknd 12752 14 of of IN cord-010119-t1x9gknd 12752 15 a a DT cord-010119-t1x9gknd 12752 16 blood blood NN cord-010119-t1x9gknd 12752 17 bank bank NN cord-010119-t1x9gknd 12752 18 information information NN cord-010119-t1x9gknd 12752 19 system system NN cord-010119-t1x9gknd 12752 20 ( ( -LRB- cord-010119-t1x9gknd 12752 21 BIS BIS NNP cord-010119-t1x9gknd 12752 22 ) ) -RRB- cord-010119-t1x9gknd 12752 23 . . . cord-010119-t1x9gknd 12753 1 Validation validation NN cord-010119-t1x9gknd 12753 2 and and CC cord-010119-t1x9gknd 12753 3 implementation implementation NN cord-010119-t1x9gknd 12753 4 of of IN cord-010119-t1x9gknd 12753 5 a a DT cord-010119-t1x9gknd 12753 6 BIS BIS NNP cord-010119-t1x9gknd 12753 7 is be VBZ cord-010119-t1x9gknd 12753 8 described describe VBN cord-010119-t1x9gknd 12753 9 for for IN cord-010119-t1x9gknd 12753 10 centralized centralized JJ cord-010119-t1x9gknd 12753 11 large large JJ cord-010119-t1x9gknd 12753 12 blood blood NN cord-010119-t1x9gknd 12753 13 bank bank NN cord-010119-t1x9gknd 12753 14 and and CC cord-010119-t1x9gknd 12753 15 literature literature NN cord-010119-t1x9gknd 12753 16 and and CC cord-010119-t1x9gknd 12753 17 guidelines guideline NNS cord-010119-t1x9gknd 12753 18 are be VBP cord-010119-t1x9gknd 12753 19 lacking lack VBG cord-010119-t1x9gknd 12753 20 for for IN cord-010119-t1x9gknd 12753 21 the the DT cord-010119-t1x9gknd 12753 22 nonautomated nonautomated JJ cord-010119-t1x9gknd 12753 23 small small JJ cord-010119-t1x9gknd 12753 24 scale scale NN cord-010119-t1x9gknd 12753 25 blood blood NN cord-010119-t1x9gknd 12753 26 bank bank NN cord-010119-t1x9gknd 12753 27 environment environment NN cord-010119-t1x9gknd 12753 28 . . . cord-010119-t1x9gknd 12753 29 . . . cord-010119-t1x9gknd 12754 1 Small small JJ cord-010119-t1x9gknd 12754 2 - - HYPH cord-010119-t1x9gknd 12754 3 scale scale NN cord-010119-t1x9gknd 12754 4 blood blood NN cord-010119-t1x9gknd 12754 5 banks bank NNS cord-010119-t1x9gknd 12754 6 face face VBP cord-010119-t1x9gknd 12754 7 specific specific JJ cord-010119-t1x9gknd 12754 8 challenges challenge NNS cord-010119-t1x9gknd 12754 9 for for IN cord-010119-t1x9gknd 12754 10 computerization computerization NN cord-010119-t1x9gknd 12754 11 in in IN cord-010119-t1x9gknd 12754 12 relation relation NN cord-010119-t1x9gknd 12754 13 to to IN cord-010119-t1x9gknd 12754 14 economies economy NNS cord-010119-t1x9gknd 12754 15 of of IN cord-010119-t1x9gknd 12754 16 scale scale NN cord-010119-t1x9gknd 12754 17 and and CC cord-010119-t1x9gknd 12754 18 existing existing JJ cord-010119-t1x9gknd 12754 19 processes process NNS cord-010119-t1x9gknd 12754 20 requiring require VBG cord-010119-t1x9gknd 12754 21 special special JJ cord-010119-t1x9gknd 12754 22 attention attention NN cord-010119-t1x9gknd 12754 23 . . . cord-010119-t1x9gknd 12755 1 For for IN cord-010119-t1x9gknd 12755 2 the the DT cord-010119-t1x9gknd 12755 3 introduction introduction NN cord-010119-t1x9gknd 12755 4 of of IN cord-010119-t1x9gknd 12755 5 a a DT cord-010119-t1x9gknd 12755 6 BIS BIS NNP cord-010119-t1x9gknd 12755 7 at at IN cord-010119-t1x9gknd 12755 8 the the DT cord-010119-t1x9gknd 12755 9 blood blood NN cord-010119-t1x9gknd 12755 10 bank bank NN cord-010119-t1x9gknd 12755 11 of of IN cord-010119-t1x9gknd 12755 12 the the DT cord-010119-t1x9gknd 12755 13 Dutch dutch JJ cord-010119-t1x9gknd 12755 14 Caribbean caribbean JJ cord-010119-t1x9gknd 12755 15 island island NN cord-010119-t1x9gknd 12755 16 of of IN cord-010119-t1x9gknd 12755 17 Curaçao Curaçao NNP cord-010119-t1x9gknd 12755 18 a a DT cord-010119-t1x9gknd 12755 19 specific specific JJ cord-010119-t1x9gknd 12755 20 procedure procedure NN cord-010119-t1x9gknd 12755 21 was be VBD cord-010119-t1x9gknd 12755 22 designed design VBN cord-010119-t1x9gknd 12755 23 based base VBN cord-010119-t1x9gknd 12755 24 on on IN cord-010119-t1x9gknd 12755 25 existing exist VBG cord-010119-t1x9gknd 12755 26 guidelines guideline NNS cord-010119-t1x9gknd 12755 27 and and CC cord-010119-t1x9gknd 12755 28 adapted adapt VBN cord-010119-t1x9gknd 12755 29 to to IN cord-010119-t1x9gknd 12755 30 the the DT cord-010119-t1x9gknd 12755 31 local local JJ cord-010119-t1x9gknd 12755 32 setting setting NN cord-010119-t1x9gknd 12755 33 . . . cord-010119-t1x9gknd 12756 1 Study Study NNP cord-010119-t1x9gknd 12756 2 Design Design NNP cord-010119-t1x9gknd 12756 3 / / SYM cord-010119-t1x9gknd 12756 4 Method method NN cord-010119-t1x9gknd 12756 5 : : : cord-010119-t1x9gknd 12757 1 The the DT cord-010119-t1x9gknd 12757 2 Red Red NNP cord-010119-t1x9gknd 12757 3 Cross Cross NNP cord-010119-t1x9gknd 12757 4 Blood Blood NNP cord-010119-t1x9gknd 12757 5 Bank Bank NNP cord-010119-t1x9gknd 12757 6 Foundation Foundation NNP cord-010119-t1x9gknd 12757 7 Curaçao Curaçao NNP cord-010119-t1x9gknd 12757 8 is be VBZ cord-010119-t1x9gknd 12757 9 the the DT cord-010119-t1x9gknd 12757 10 sole sole JJ cord-010119-t1x9gknd 12757 11 provider provider NN cord-010119-t1x9gknd 12757 12 of of IN cord-010119-t1x9gknd 12757 13 labile labile JJ cord-010119-t1x9gknd 12757 14 blood blood NN cord-010119-t1x9gknd 12757 15 components component NNS cord-010119-t1x9gknd 12757 16 for for IN cord-010119-t1x9gknd 12757 17 the the DT cord-010119-t1x9gknd 12757 18 Dutch dutch JJ cord-010119-t1x9gknd 12757 19 Caribbean caribbean JJ cord-010119-t1x9gknd 12757 20 islands island NNS cord-010119-t1x9gknd 12757 21 of of IN cord-010119-t1x9gknd 12757 22 Curaçao Curaçao NNP cord-010119-t1x9gknd 12757 23 , , , cord-010119-t1x9gknd 12757 24 Bonaire Bonaire NNP cord-010119-t1x9gknd 12757 25 and and CC cord-010119-t1x9gknd 12757 26 Sint Sint NNP cord-010119-t1x9gknd 12757 27 Maarten Maarten NNP cord-010119-t1x9gknd 12757 28 . . . cord-010119-t1x9gknd 12758 1 After after IN cord-010119-t1x9gknd 12758 2 selection selection NN cord-010119-t1x9gknd 12758 3 of of IN cord-010119-t1x9gknd 12758 4 the the DT cord-010119-t1x9gknd 12758 5 BIS BIS NNP cord-010119-t1x9gknd 12758 6 provider provider NN cord-010119-t1x9gknd 12758 7 for for IN cord-010119-t1x9gknd 12758 8 implementation implementation NN cord-010119-t1x9gknd 12758 9 ISBT ISBT NNP cord-010119-t1x9gknd 12758 10 and and CC cord-010119-t1x9gknd 12758 11 BCSH BCSH NNP cord-010119-t1x9gknd 12758 12 guidelines guideline NNS cord-010119-t1x9gknd 12758 13 for for IN cord-010119-t1x9gknd 12758 14 validation validation NN cord-010119-t1x9gknd 12758 15 of of IN cord-010119-t1x9gknd 12758 16 information information NN cord-010119-t1x9gknd 12758 17 systems system NNS cord-010119-t1x9gknd 12758 18 in in IN cord-010119-t1x9gknd 12758 19 blood blood NN cord-010119-t1x9gknd 12758 20 establishments establishment NNS cord-010119-t1x9gknd 12758 21 were be VBD cord-010119-t1x9gknd 12758 22 carefully carefully RB cord-010119-t1x9gknd 12758 23 analyzed analyze VBN cord-010119-t1x9gknd 12758 24 to to TO cord-010119-t1x9gknd 12758 25 prepare prepare VB cord-010119-t1x9gknd 12758 26 the the DT cord-010119-t1x9gknd 12758 27 design design NN cord-010119-t1x9gknd 12758 28 of of IN cord-010119-t1x9gknd 12758 29 local local JJ cord-010119-t1x9gknd 12758 30 procedures procedure NNS cord-010119-t1x9gknd 12758 31 . . . cord-010119-t1x9gknd 12759 1 These these DT cord-010119-t1x9gknd 12759 2 procedures procedure NNS cord-010119-t1x9gknd 12759 3 were be VBD cord-010119-t1x9gknd 12759 4 meant mean VBN cord-010119-t1x9gknd 12759 5 to to TO cord-010119-t1x9gknd 12759 6 evaluate evaluate VB cord-010119-t1x9gknd 12759 7 and and CC cord-010119-t1x9gknd 12759 8 validate validate VB cord-010119-t1x9gknd 12759 9 the the DT cord-010119-t1x9gknd 12759 10 features feature NNS cord-010119-t1x9gknd 12759 11 of of IN cord-010119-t1x9gknd 12759 12 a a DT cord-010119-t1x9gknd 12759 13 BIS BIS NNP cord-010119-t1x9gknd 12759 14 ( ( -LRB- cord-010119-t1x9gknd 12759 15 e e NNP cord-010119-t1x9gknd 12759 16 - - NNP cord-010119-t1x9gknd 12759 17 Delphyn Delphyn NNP cord-010119-t1x9gknd 12759 18 , , , cord-010119-t1x9gknd 12759 19 Hemasoft Hemasoft NNP cord-010119-t1x9gknd 12759 20 America America NNP cord-010119-t1x9gknd 12759 21 , , , cord-010119-t1x9gknd 12759 22 Miami Miami NNP cord-010119-t1x9gknd 12759 23 , , , cord-010119-t1x9gknd 12759 24 USA USA NNP cord-010119-t1x9gknd 12759 25 ) ) -RRB- cord-010119-t1x9gknd 12759 26 before before IN cord-010119-t1x9gknd 12759 27 introduction introduction NN cord-010119-t1x9gknd 12759 28 . . . cord-010119-t1x9gknd 12760 1 The the DT cord-010119-t1x9gknd 12760 2 outcome outcome NN cord-010119-t1x9gknd 12760 3 of of IN cord-010119-t1x9gknd 12760 4 the the DT cord-010119-t1x9gknd 12760 5 approach approach NN cord-010119-t1x9gknd 12760 6 was be VBD cord-010119-t1x9gknd 12760 7 entered enter VBN cord-010119-t1x9gknd 12760 8 in in IN cord-010119-t1x9gknd 12760 9 worksheets worksheet NNS cord-010119-t1x9gknd 12760 10 that that WDT cord-010119-t1x9gknd 12760 11 were be VBD cord-010119-t1x9gknd 12760 12 evaluated evaluate VBN cord-010119-t1x9gknd 12760 13 by by IN cord-010119-t1x9gknd 12760 14 the the DT cord-010119-t1x9gknd 12760 15 implementation implementation NN cord-010119-t1x9gknd 12760 16 team team NN cord-010119-t1x9gknd 12760 17 and and CC cord-010119-t1x9gknd 12760 18 management management NN cord-010119-t1x9gknd 12760 19 . . . cord-010119-t1x9gknd 12761 1 From from IN cord-010119-t1x9gknd 12761 2 this this DT cord-010119-t1x9gknd 12761 3 the the DT cord-010119-t1x9gknd 12761 4 implementation implementation NN cord-010119-t1x9gknd 12761 5 plan plan NN cord-010119-t1x9gknd 12761 6 was be VBD cord-010119-t1x9gknd 12761 7 designed design VBN cord-010119-t1x9gknd 12761 8 and and CC cord-010119-t1x9gknd 12761 9 implemented implement VBN cord-010119-t1x9gknd 12761 10 . . . cord-010119-t1x9gknd 12762 1 An an DT cord-010119-t1x9gknd 12762 2 external external JJ cord-010119-t1x9gknd 12762 3 auditor auditor NN cord-010119-t1x9gknd 12762 4 ( ( -LRB- cord-010119-t1x9gknd 12762 5 Sanquin Sanquin NNP cord-010119-t1x9gknd 12762 6 Consulting Consulting NNP cord-010119-t1x9gknd 12762 7 Services Services NNPS cord-010119-t1x9gknd 12762 8 , , , cord-010119-t1x9gknd 12762 9 Amsterdam Amsterdam NNP cord-010119-t1x9gknd 12762 10 , , , cord-010119-t1x9gknd 12762 11 Netherlands Netherlands NNP cord-010119-t1x9gknd 12762 12 ) ) -RRB- cord-010119-t1x9gknd 12762 13 was be VBD cord-010119-t1x9gknd 12762 14 invited invite VBN cord-010119-t1x9gknd 12762 15 to to TO cord-010119-t1x9gknd 12762 16 evaluate evaluate VB cord-010119-t1x9gknd 12762 17 the the DT cord-010119-t1x9gknd 12762 18 implementation implementation NN cord-010119-t1x9gknd 12762 19 and and CC cord-010119-t1x9gknd 12762 20 validation validation NN cord-010119-t1x9gknd 12762 21 plan plan NN cord-010119-t1x9gknd 12762 22 and and CC cord-010119-t1x9gknd 12762 23 its -PRON- PRP$ cord-010119-t1x9gknd 12762 24 practical practical JJ cord-010119-t1x9gknd 12762 25 implementation implementation NN cord-010119-t1x9gknd 12762 26 . . . cord-010119-t1x9gknd 12763 1 The the DT cord-010119-t1x9gknd 12763 2 evaluation evaluation NN cord-010119-t1x9gknd 12763 3 was be VBD cord-010119-t1x9gknd 12763 4 performed perform VBN cord-010119-t1x9gknd 12763 5 according accord VBG cord-010119-t1x9gknd 12763 6 to to IN cord-010119-t1x9gknd 12763 7 risk risk NN cord-010119-t1x9gknd 12763 8 assessment assessment NN cord-010119-t1x9gknd 12763 9 of of IN cord-010119-t1x9gknd 12763 10 critical critical JJ cord-010119-t1x9gknd 12763 11 process process NN cord-010119-t1x9gknd 12763 12 steps step NNS cord-010119-t1x9gknd 12763 13 . . . cord-010119-t1x9gknd 12764 1 Results result NNS cord-010119-t1x9gknd 12765 1 /Finding /finde VBG cord-010119-t1x9gknd 12765 2 : : : cord-010119-t1x9gknd 12766 1 Based base VBN cord-010119-t1x9gknd 12766 2 on on IN cord-010119-t1x9gknd 12766 3 the the DT cord-010119-t1x9gknd 12766 4 ISBT ISBT NNP cord-010119-t1x9gknd 12766 5 and and CC cord-010119-t1x9gknd 12766 6 BCSH BCSH NNP cord-010119-t1x9gknd 12766 7 guidelines guideline NNS cord-010119-t1x9gknd 12767 1 a a DT cord-010119-t1x9gknd 12767 2 process process NN cord-010119-t1x9gknd 12767 3 flow flow NN cord-010119-t1x9gknd 12767 4 chart chart NN cord-010119-t1x9gknd 12767 5 describing describe VBG cord-010119-t1x9gknd 12767 6 the the DT cord-010119-t1x9gknd 12767 7 relevant relevant JJ cord-010119-t1x9gknd 12767 8 phases phase NNS cord-010119-t1x9gknd 12767 9 and and CC cord-010119-t1x9gknd 12767 10 critical critical JJ cord-010119-t1x9gknd 12767 11 steps step NNS cord-010119-t1x9gknd 12767 12 for for IN cord-010119-t1x9gknd 12767 13 introduction introduction NN cord-010119-t1x9gknd 12767 14 and and CC cord-010119-t1x9gknd 12767 15 validation validation NN cord-010119-t1x9gknd 12767 16 of of IN cord-010119-t1x9gknd 12767 17 a a DT cord-010119-t1x9gknd 12767 18 BIS BIS NNP cord-010119-t1x9gknd 12767 19 was be VBD cord-010119-t1x9gknd 12767 20 designed design VBN cord-010119-t1x9gknd 12767 21 . . . cord-010119-t1x9gknd 12768 1 Comparison comparison NN cord-010119-t1x9gknd 12768 2 of of IN cord-010119-t1x9gknd 12768 3 the the DT cord-010119-t1x9gknd 12768 4 current current JJ cord-010119-t1x9gknd 12768 5 processes process NNS cord-010119-t1x9gknd 12768 6 and and CC cord-010119-t1x9gknd 12768 7 procedures procedure NNS cord-010119-t1x9gknd 12768 8 were be VBD cord-010119-t1x9gknd 12768 9 compared compare VBN cord-010119-t1x9gknd 12768 10 to to IN cord-010119-t1x9gknd 12768 11 the the DT cord-010119-t1x9gknd 12768 12 BIS BIS NNP cord-010119-t1x9gknd 12768 13 characteristics characteristic NNS cord-010119-t1x9gknd 12768 14 making make VBG cord-010119-t1x9gknd 12768 15 use use NN cord-010119-t1x9gknd 12768 16 of of IN cord-010119-t1x9gknd 12768 17 8 8 CD cord-010119-t1x9gknd 12768 18 worksheets worksheet NNS cord-010119-t1x9gknd 12768 19 . . . cord-010119-t1x9gknd 12769 1 With with IN cord-010119-t1x9gknd 12769 2 these these DT cord-010119-t1x9gknd 12769 3 worksheets worksheet NNS cord-010119-t1x9gknd 12769 4 the the DT cord-010119-t1x9gknd 12769 5 existing exist VBG cord-010119-t1x9gknd 12769 6 gaps gap NNS cord-010119-t1x9gknd 12769 7 with with IN cord-010119-t1x9gknd 12769 8 the the DT cord-010119-t1x9gknd 12769 9 BIS BIS NNP cord-010119-t1x9gknd 12769 10 procedures procedure NNS cord-010119-t1x9gknd 12769 11 were be VBD cord-010119-t1x9gknd 12769 12 carefully carefully RB cord-010119-t1x9gknd 12769 13 described describe VBN cord-010119-t1x9gknd 12769 14 . . . cord-010119-t1x9gknd 12770 1 These these DT cord-010119-t1x9gknd 12770 2 gaps gap NNS cord-010119-t1x9gknd 12770 3 and and CC cord-010119-t1x9gknd 12770 4 the the DT cord-010119-t1x9gknd 12770 5 appropriate appropriate JJ cord-010119-t1x9gknd 12770 6 procedural procedural JJ cord-010119-t1x9gknd 12770 7 changes change NNS cord-010119-t1x9gknd 12770 8 for for IN cord-010119-t1x9gknd 12770 9 BIS BIS NNP cord-010119-t1x9gknd 12770 10 or or CC cord-010119-t1x9gknd 12770 11 blood blood NN cord-010119-t1x9gknd 12770 12 bank bank NN cord-010119-t1x9gknd 12770 13 were be VBD cord-010119-t1x9gknd 12770 14 effectuated effectuate VBN cord-010119-t1x9gknd 12770 15 . . . cord-010119-t1x9gknd 12771 1 The the DT cord-010119-t1x9gknd 12771 2 worksheets worksheet NNS cord-010119-t1x9gknd 12771 3 also also RB cord-010119-t1x9gknd 12771 4 provided provide VBD cord-010119-t1x9gknd 12771 5 the the DT cord-010119-t1x9gknd 12771 6 basis basis NN cord-010119-t1x9gknd 12771 7 for for IN cord-010119-t1x9gknd 12771 8 staff staff NN cord-010119-t1x9gknd 12771 9 training training NN cord-010119-t1x9gknd 12771 10 in in IN cord-010119-t1x9gknd 12771 11 a a DT cord-010119-t1x9gknd 12771 12 separate separate JJ cord-010119-t1x9gknd 12771 13 training training NN cord-010119-t1x9gknd 12771 14 environment environment NN cord-010119-t1x9gknd 12771 15 before before IN cord-010119-t1x9gknd 12771 16 BIS BIS NNP cord-010119-t1x9gknd 12771 17 introduction introduction NN cord-010119-t1x9gknd 12771 18 . . . cord-010119-t1x9gknd 12772 1 During during IN cord-010119-t1x9gknd 12772 2 the the DT cord-010119-t1x9gknd 12772 3 early early JJ cord-010119-t1x9gknd 12772 4 validation validation NN cord-010119-t1x9gknd 12772 5 phase phase NN cord-010119-t1x9gknd 12772 6 all all DT cord-010119-t1x9gknd 12772 7 procedures procedure NNS cord-010119-t1x9gknd 12772 8 and and CC cord-010119-t1x9gknd 12772 9 processes process NNS cord-010119-t1x9gknd 12772 10 were be VBD cord-010119-t1x9gknd 12772 11 audited audit VBN cord-010119-t1x9gknd 12772 12 by by IN cord-010119-t1x9gknd 12772 13 an an DT cord-010119-t1x9gknd 12772 14 external external JJ cord-010119-t1x9gknd 12772 15 auditor auditor NN cord-010119-t1x9gknd 12772 16 . . . cord-010119-t1x9gknd 12773 1 With with IN cord-010119-t1x9gknd 12773 2 the the DT cord-010119-t1x9gknd 12773 3 feedback feedback NN cord-010119-t1x9gknd 12773 4 of of IN cord-010119-t1x9gknd 12773 5 the the DT cord-010119-t1x9gknd 12773 6 expert expert NN cord-010119-t1x9gknd 12773 7 several several JJ cord-010119-t1x9gknd 12773 8 improvements improvement NNS cord-010119-t1x9gknd 12773 9 were be VBD cord-010119-t1x9gknd 12773 10 added add VBN cord-010119-t1x9gknd 12773 11 for for IN cord-010119-t1x9gknd 12773 12 the the DT cord-010119-t1x9gknd 12773 13 validation validation NN cord-010119-t1x9gknd 12773 14 and and CC cord-010119-t1x9gknd 12773 15 subsequent subsequent JJ cord-010119-t1x9gknd 12773 16 implementation implementation NN cord-010119-t1x9gknd 12773 17 processes process NNS cord-010119-t1x9gknd 12773 18 . . . cord-010119-t1x9gknd 12774 1 Conclusion conclusion NN cord-010119-t1x9gknd 12774 2 : : : cord-010119-t1x9gknd 12774 3 With with IN cord-010119-t1x9gknd 12774 4 the the DT cord-010119-t1x9gknd 12774 5 use use NN cord-010119-t1x9gknd 12774 6 of of IN cord-010119-t1x9gknd 12774 7 existing exist VBG cord-010119-t1x9gknd 12774 8 international international JJ cord-010119-t1x9gknd 12774 9 guidelines guideline NNS cord-010119-t1x9gknd 12774 10 a a DT cord-010119-t1x9gknd 12774 11 validation validation NN cord-010119-t1x9gknd 12774 12 and and CC cord-010119-t1x9gknd 12774 13 implementation implementation NN cord-010119-t1x9gknd 12774 14 plan plan NN cord-010119-t1x9gknd 12774 15 was be VBD cord-010119-t1x9gknd 12774 16 designed design VBN cord-010119-t1x9gknd 12774 17 to to TO cord-010119-t1x9gknd 12774 18 prepare prepare VB cord-010119-t1x9gknd 12774 19 for for IN cord-010119-t1x9gknd 12774 20 successful successful JJ cord-010119-t1x9gknd 12774 21 introduction introduction NN cord-010119-t1x9gknd 12774 22 of of IN cord-010119-t1x9gknd 12774 23 a a DT cord-010119-t1x9gknd 12774 24 BIS BIS NNP cord-010119-t1x9gknd 12774 25 in in IN cord-010119-t1x9gknd 12774 26 a a DT cord-010119-t1x9gknd 12774 27 small small JJ cord-010119-t1x9gknd 12774 28 scale scale NN cord-010119-t1x9gknd 12774 29 Caribbean caribbean JJ cord-010119-t1x9gknd 12774 30 blood blood NN cord-010119-t1x9gknd 12774 31 bank bank NN cord-010119-t1x9gknd 12774 32 . . . cord-010119-t1x9gknd 12775 1 The the DT cord-010119-t1x9gknd 12775 2 program program NN cord-010119-t1x9gknd 12775 3 as as IN cord-010119-t1x9gknd 12775 4 designed design VBN cord-010119-t1x9gknd 12775 5 seems seem VBZ cord-010119-t1x9gknd 12775 6 well well RB cord-010119-t1x9gknd 12775 7 suited suited JJ cord-010119-t1x9gknd 12775 8 for for IN cord-010119-t1x9gknd 12775 9 small small JJ cord-010119-t1x9gknd 12775 10 scale scale NN cord-010119-t1x9gknd 12775 11 blood blood NN cord-010119-t1x9gknd 12775 12 banks bank NNS cord-010119-t1x9gknd 12775 13 contemplating contemplate VBG cord-010119-t1x9gknd 12775 14 introduction introduction NN cord-010119-t1x9gknd 12775 15 of of IN cord-010119-t1x9gknd 12775 16 a a DT cord-010119-t1x9gknd 12775 17 BIS bis NN cord-010119-t1x9gknd 12775 18 . . . cord-010119-t1x9gknd 12776 1 Time time NN cord-010119-t1x9gknd 12776 2 and and CC cord-010119-t1x9gknd 12776 3 Cost Cost NNP cord-010119-t1x9gknd 12776 4 Savings saving NNS cord-010119-t1x9gknd 12776 5 through through IN cord-010119-t1x9gknd 12776 6 Implementation implementation NN cord-010119-t1x9gknd 12776 7 of of IN cord-010119-t1x9gknd 12776 8 a a DT cord-010119-t1x9gknd 12776 9 Remote Remote NNP cord-010119-t1x9gknd 12776 10 Blood Blood NNP cord-010119-t1x9gknd 12776 11 Fridge Fridge NNP cord-010119-t1x9gknd 12776 12 Jessica Jessica NNP cord-010119-t1x9gknd 12776 13 Peters Peters NNP cord-010119-t1x9gknd 12777 1 * * NFP cord-010119-t1x9gknd 12777 2 1 1 CD cord-010119-t1x9gknd 12777 3 , , , cord-010119-t1x9gknd 12777 4 Dee Dee NNP cord-010119-t1x9gknd 12777 5 Dee Dee NNP cord-010119-t1x9gknd 12777 6 Cassidy Cassidy NNP cord-010119-t1x9gknd 12777 7 1 1 CD cord-010119-t1x9gknd 12777 8 , , , cord-010119-t1x9gknd 12777 9 Jed Jed NNP cord-010119-t1x9gknd 12777 10 B B NNP cord-010119-t1x9gknd 12777 11 Gorlin Gorlin NNP cord-010119-t1x9gknd 12777 12 1,2 1,2 CD cord-010119-t1x9gknd 12777 13 and and CC cord-010119-t1x9gknd 12777 14 Nancy Nancy NNP cord-010119-t1x9gknd 12777 15 L L NNP cord-010119-t1x9gknd 12777 16 Van Van NNP cord-010119-t1x9gknd 12777 17 Buren Buren NNP cord-010119-t1x9gknd 12778 1 1,2 1,2 LS cord-010119-t1x9gknd 12778 2 . . . cord-010119-t1x9gknd 12779 1 1 1 CD cord-010119-t1x9gknd 12779 2 Hennepin Hennepin NNP cord-010119-t1x9gknd 12779 3 County County NNP cord-010119-t1x9gknd 12779 4 Medical Medical NNP cord-010119-t1x9gknd 12779 5 Center Center NNP cord-010119-t1x9gknd 12779 6 , , , cord-010119-t1x9gknd 12779 7 2 2 CD cord-010119-t1x9gknd 12779 8 Innovative Innovative NNP cord-010119-t1x9gknd 12779 9 Blood Blood NNP cord-010119-t1x9gknd 12779 10 Resources Resources NNPS cord-010119-t1x9gknd 12779 11 Background Background NNP cord-010119-t1x9gknd 12779 12 / / SYM cord-010119-t1x9gknd 12779 13 Case Case NNP cord-010119-t1x9gknd 12779 14 Studies Studies NNPS cord-010119-t1x9gknd 12779 15 : : : cord-010119-t1x9gknd 12779 16 Rapid rapid JJ cord-010119-t1x9gknd 12779 17 delivery delivery NN cord-010119-t1x9gknd 12779 18 of of IN cord-010119-t1x9gknd 12779 19 emergency emergency NN cord-010119-t1x9gknd 12779 20 release release NN cord-010119-t1x9gknd 12779 21 group group NN cord-010119-t1x9gknd 12779 22 O o NN cord-010119-t1x9gknd 12779 23 red red JJ cord-010119-t1x9gknd 12779 24 blood blood NN cord-010119-t1x9gknd 12779 25 cells cell NNS cord-010119-t1x9gknd 12779 26 ( ( -LRB- cord-010119-t1x9gknd 12779 27 RBC RBC NNP cord-010119-t1x9gknd 12779 28 ) ) -RRB- cord-010119-t1x9gknd 12779 29 are be VBP cord-010119-t1x9gknd 12779 30 vital vital JJ cord-010119-t1x9gknd 12779 31 to to IN cord-010119-t1x9gknd 12779 32 patient patient JJ cord-010119-t1x9gknd 12779 33 care care NN cord-010119-t1x9gknd 12779 34 . . . cord-010119-t1x9gknd 12780 1 Commercial commercial JJ cord-010119-t1x9gknd 12780 2 remote remote JJ cord-010119-t1x9gknd 12780 3 blood blood NN cord-010119-t1x9gknd 12780 4 fridge fridge NN cord-010119-t1x9gknd 12780 5 packages package NNS cord-010119-t1x9gknd 12780 6 are be VBP cord-010119-t1x9gknd 12780 7 available available JJ cord-010119-t1x9gknd 12780 8 but but CC cord-010119-t1x9gknd 12780 9 have have VBP cord-010119-t1x9gknd 12780 10 large large JJ cord-010119-t1x9gknd 12780 11 upfront upfront NN cord-010119-t1x9gknd 12780 12 and and CC cord-010119-t1x9gknd 12780 13 maintenance maintenance NN cord-010119-t1x9gknd 12780 14 costs cost NNS cord-010119-t1x9gknd 12780 15 . . . cord-010119-t1x9gknd 12781 1 We -PRON- PRP cord-010119-t1x9gknd 12781 2 implemented implement VBD cord-010119-t1x9gknd 12781 3 a a DT cord-010119-t1x9gknd 12781 4 remote remote JJ cord-010119-t1x9gknd 12781 5 blood blood NN cord-010119-t1x9gknd 12781 6 fridge fridge NN cord-010119-t1x9gknd 12781 7 directly directly RB cord-010119-t1x9gknd 12781 8 in in IN cord-010119-t1x9gknd 12781 9 our -PRON- PRP$ cord-010119-t1x9gknd 12781 10 Emergency Emergency NNP cord-010119-t1x9gknd 12781 11 Department Department NNP cord-010119-t1x9gknd 12781 12 ( ( -LRB- cord-010119-t1x9gknd 12781 13 ED ED NNP cord-010119-t1x9gknd 12781 14 ) ) -RRB- cord-010119-t1x9gknd 12781 15 using use VBG cord-010119-t1x9gknd 12781 16 an an DT cord-010119-t1x9gknd 12781 17 under under IN cord-010119-t1x9gknd 12781 18 counter counter JJ cord-010119-t1x9gknd 12781 19 fridge fridge NN cord-010119-t1x9gknd 12781 20 requiring require VBG cord-010119-t1x9gknd 12781 21 ID ID NNP cord-010119-t1x9gknd 12781 22 access access NN cord-010119-t1x9gknd 12781 23 , , , cord-010119-t1x9gknd 12781 24 and and CC cord-010119-t1x9gknd 12781 25 a a DT cord-010119-t1x9gknd 12781 26 selfdeveloped selfdeveloped JJ cord-010119-t1x9gknd 12781 27 IOS IOS NNP cord-010119-t1x9gknd 12781 28 application application NN cord-010119-t1x9gknd 12781 29 that that WDT cord-010119-t1x9gknd 12781 30 scans scan NNS cord-010119-t1x9gknd 12781 31 , , , cord-010119-t1x9gknd 12781 32 tracks track NNS cord-010119-t1x9gknd 12781 33 and and CC cord-010119-t1x9gknd 12781 34 real real JJ cord-010119-t1x9gknd 12781 35 - - HYPH cord-010119-t1x9gknd 12781 36 time time NN cord-010119-t1x9gknd 12781 37 alerts alert VBZ cord-010119-t1x9gknd 12781 38 Transfusion Transfusion NNP cord-010119-t1x9gknd 12781 39 Service Service NNP cord-010119-t1x9gknd 12781 40 ( ( -LRB- cord-010119-t1x9gknd 12781 41 TS TS NNP cord-010119-t1x9gknd 12781 42 ) ) -RRB- cord-010119-t1x9gknd 12781 43 to to IN cord-010119-t1x9gknd 12781 44 products product NNS cord-010119-t1x9gknd 12781 45 used use VBN cord-010119-t1x9gknd 12781 46 and and CC cord-010119-t1x9gknd 12781 47 to to TO cord-010119-t1x9gknd 12781 48 whom whom WP cord-010119-t1x9gknd 12781 49 they -PRON- PRP cord-010119-t1x9gknd 12781 50 were be VBD cord-010119-t1x9gknd 12781 51 dispensed dispense VBN cord-010119-t1x9gknd 12781 52 . . . cord-010119-t1x9gknd 12782 1 Prior prior RB cord-010119-t1x9gknd 12782 2 to to IN cord-010119-t1x9gknd 12782 3 ED ED NNP cord-010119-t1x9gknd 12782 4 fridge fridge NN cord-010119-t1x9gknd 12782 5 implementation implementation NN cord-010119-t1x9gknd 12782 6 , , , cord-010119-t1x9gknd 12782 7 RBC RBC NNP cord-010119-t1x9gknd 12782 8 units unit NNS cord-010119-t1x9gknd 12782 9 were be VBD cord-010119-t1x9gknd 12782 10 verbally verbally RB cord-010119-t1x9gknd 12782 11 requested request VBN cord-010119-t1x9gknd 12782 12 and and CC cord-010119-t1x9gknd 12782 13 an an DT cord-010119-t1x9gknd 12782 14 ED ED NNP cord-010119-t1x9gknd 12782 15 blood blood NN cord-010119-t1x9gknd 12782 16 runner runner NN cord-010119-t1x9gknd 12782 17 would would MD cord-010119-t1x9gknd 12782 18 pick pick VB cord-010119-t1x9gknd 12782 19 up up RP cord-010119-t1x9gknd 12782 20 and and CC cord-010119-t1x9gknd 12782 21 return return VB cord-010119-t1x9gknd 12782 22 the the DT cord-010119-t1x9gknd 12782 23 cooler cool JJR cord-010119-t1x9gknd 12782 24 . . . cord-010119-t1x9gknd 12783 1 Given give VBN cord-010119-t1x9gknd 12783 2 that that IN cord-010119-t1x9gknd 12783 3 our -PRON- PRP$ cord-010119-t1x9gknd 12783 4 ED ED NNP cord-010119-t1x9gknd 12783 5 is be VBZ cord-010119-t1x9gknd 12783 6 located locate VBN cord-010119-t1x9gknd 12783 7 in in IN cord-010119-t1x9gknd 12783 8 a a DT cord-010119-t1x9gknd 12783 9 separate separate JJ cord-010119-t1x9gknd 12783 10 building building NN cord-010119-t1x9gknd 12783 11 from from IN cord-010119-t1x9gknd 12783 12 the the DT cord-010119-t1x9gknd 12783 13 TS TS NNP cord-010119-t1x9gknd 12783 14 , , , cord-010119-t1x9gknd 12783 15 this this DT cord-010119-t1x9gknd 12783 16 meant mean VBD cord-010119-t1x9gknd 12783 17 10 10 CD cord-010119-t1x9gknd 12783 18 or or CC cord-010119-t1x9gknd 12783 19 more more JJR cord-010119-t1x9gknd 12783 20 minutes minute NNS cord-010119-t1x9gknd 12783 21 may may MD cord-010119-t1x9gknd 12783 22 be be VB cord-010119-t1x9gknd 12783 23 required require VBN cord-010119-t1x9gknd 12783 24 for for IN cord-010119-t1x9gknd 12783 25 transit transit NN cord-010119-t1x9gknd 12783 26 of of IN cord-010119-t1x9gknd 12783 27 units unit NNS cord-010119-t1x9gknd 12783 28 often often RB cord-010119-t1x9gknd 12783 29 released release VBN cord-010119-t1x9gknd 12783 30 in in IN cord-010119-t1x9gknd 12783 31 less less JJR cord-010119-t1x9gknd 12783 32 than than IN cord-010119-t1x9gknd 12783 33 5 5 CD cord-010119-t1x9gknd 12783 34 minutes minute NNS cord-010119-t1x9gknd 12783 35 . . . cord-010119-t1x9gknd 12784 1 The the DT cord-010119-t1x9gknd 12784 2 net net JJ cord-010119-t1x9gknd 12784 3 effect effect NN cord-010119-t1x9gknd 12784 4 was be VBD cord-010119-t1x9gknd 12784 5 that that IN cord-010119-t1x9gknd 12784 6 providers provider NNS cord-010119-t1x9gknd 12784 7 would would MD cord-010119-t1x9gknd 12784 8 routinely routinely RB cord-010119-t1x9gknd 12784 9 order order VB cord-010119-t1x9gknd 12784 10 products product NNS cord-010119-t1x9gknd 12784 11 to to TO cord-010119-t1x9gknd 12784 12 ensure ensure VB cord-010119-t1x9gknd 12784 13 they -PRON- PRP cord-010119-t1x9gknd 12784 14 were be VBD cord-010119-t1x9gknd 12784 15 at at IN cord-010119-t1x9gknd 12784 16 the the DT cord-010119-t1x9gknd 12784 17 bedside bedside NN cord-010119-t1x9gknd 12784 18 for for IN cord-010119-t1x9gknd 12784 19 patient patient JJ cord-010119-t1x9gknd 12784 20 arrival arrival NN cord-010119-t1x9gknd 12784 21 as as IN cord-010119-t1x9gknd 12784 22 a a DT cord-010119-t1x9gknd 12784 23 precaution precaution NN cord-010119-t1x9gknd 12784 24 , , , cord-010119-t1x9gknd 12784 25 only only RB cord-010119-t1x9gknd 12784 26 to to TO cord-010119-t1x9gknd 12784 27 return return VB cord-010119-t1x9gknd 12784 28 them -PRON- PRP cord-010119-t1x9gknd 12784 29 when when WRB cord-010119-t1x9gknd 12784 30 not not RB cord-010119-t1x9gknd 12784 31 required require VBN cord-010119-t1x9gknd 12784 32 . . . cord-010119-t1x9gknd 12785 1 Implementing implement VBG cord-010119-t1x9gknd 12785 2 a a DT cord-010119-t1x9gknd 12785 3 blood blood NN cord-010119-t1x9gknd 12785 4 fridge fridge NN cord-010119-t1x9gknd 12785 5 at at IN cord-010119-t1x9gknd 12785 6 bedside bedside NN cord-010119-t1x9gknd 12785 7 resulted result VBD cord-010119-t1x9gknd 12785 8 in in IN cord-010119-t1x9gknd 12785 9 the the DT cord-010119-t1x9gknd 12785 10 predicted predict VBN cord-010119-t1x9gknd 12785 11 outcome outcome NN cord-010119-t1x9gknd 12785 12 of of IN cord-010119-t1x9gknd 12785 13 delivering deliver VBG cord-010119-t1x9gknd 12785 14 emergency emergency NN cord-010119-t1x9gknd 12785 15 release release NN cord-010119-t1x9gknd 12785 16 RBCs rbc NNS cord-010119-t1x9gknd 12785 17 more more RBR cord-010119-t1x9gknd 12785 18 quickly quickly RB cord-010119-t1x9gknd 12785 19 , , , cord-010119-t1x9gknd 12785 20 with with IN cord-010119-t1x9gknd 12785 21 the the DT cord-010119-t1x9gknd 12785 22 observed observed JJ cord-010119-t1x9gknd 12785 23 benefit benefit NN cord-010119-t1x9gknd 12785 24 of of IN cord-010119-t1x9gknd 12785 25 decreasing decrease VBG cord-010119-t1x9gknd 12785 26 wasted waste VBN cord-010119-t1x9gknd 12785 27 staff staff NN cord-010119-t1x9gknd 12785 28 time time NN cord-010119-t1x9gknd 12785 29 . . . cord-010119-t1x9gknd 12786 1 Study Study NNP cord-010119-t1x9gknd 12786 2 Design Design NNP cord-010119-t1x9gknd 12786 3 / / SYM cord-010119-t1x9gknd 12786 4 Method method NN cord-010119-t1x9gknd 12786 5 : : : cord-010119-t1x9gknd 12787 1 The the DT cord-010119-t1x9gknd 12787 2 remote remote JJ cord-010119-t1x9gknd 12787 3 blood blood NN cord-010119-t1x9gknd 12787 4 fridge fridge NN cord-010119-t1x9gknd 12787 5 was be VBD cord-010119-t1x9gknd 12787 6 implemented implement VBN cord-010119-t1x9gknd 12787 7 in in IN cord-010119-t1x9gknd 12787 8 July July NNP cord-010119-t1x9gknd 12787 9 2016 2016 CD cord-010119-t1x9gknd 12787 10 . . . cord-010119-t1x9gknd 12788 1 Data datum NNS cord-010119-t1x9gknd 12788 2 for for IN cord-010119-t1x9gknd 12788 3 RBC RBC NNP cord-010119-t1x9gknd 12788 4 requests request NNS cord-010119-t1x9gknd 12788 5 in in IN cord-010119-t1x9gknd 12788 6 coolers cooler NNS cord-010119-t1x9gknd 12788 7 , , , cord-010119-t1x9gknd 12788 8 RBC RBC NNP cord-010119-t1x9gknd 12788 9 returns return NNS cord-010119-t1x9gknd 12788 10 and and CC cord-010119-t1x9gknd 12788 11 RBC RBC NNP cord-010119-t1x9gknd 12788 12 transfusions transfusion NNS cord-010119-t1x9gknd 12788 13 from from IN cord-010119-t1x9gknd 12788 14 the the DT cord-010119-t1x9gknd 12788 15 ED ED NNP cord-010119-t1x9gknd 12788 16 was be VBD cord-010119-t1x9gknd 12788 17 collected collect VBN cord-010119-t1x9gknd 12788 18 and and CC cord-010119-t1x9gknd 12788 19 compared compare VBN cord-010119-t1x9gknd 12788 20 . . . cord-010119-t1x9gknd 12789 1 Baseline baseline JJ cord-010119-t1x9gknd 12789 2 data datum NNS cord-010119-t1x9gknd 12789 3 included include VBD cord-010119-t1x9gknd 12789 4 January January NNP cord-010119-t1x9gknd 12789 5 2015-June 2015-june CD cord-010119-t1x9gknd 12789 6 2016 2016 CD cord-010119-t1x9gknd 12789 7 , , , cord-010119-t1x9gknd 12789 8 and and CC cord-010119-t1x9gknd 12789 9 post post NN cord-010119-t1x9gknd 12789 10 change change NN cord-010119-t1x9gknd 12789 11 included include VBD cord-010119-t1x9gknd 12789 12 August August NNP cord-010119-t1x9gknd 12789 13 2016-December 2016-december CD cord-010119-t1x9gknd 12789 14 2016 2016 CD cord-010119-t1x9gknd 12789 15 . . . cord-010119-t1x9gknd 12790 1 July July NNP cord-010119-t1x9gknd 12790 2 2016 2016 CD cord-010119-t1x9gknd 12790 3 data datum NNS cord-010119-t1x9gknd 12790 4 was be VBD cord-010119-t1x9gknd 12790 5 excluded exclude VBN cord-010119-t1x9gknd 12790 6 as as IN cord-010119-t1x9gknd 12790 7 it -PRON- PRP cord-010119-t1x9gknd 12790 8 included include VBD cord-010119-t1x9gknd 12790 9 both both CC cord-010119-t1x9gknd 12790 10 the the DT cord-010119-t1x9gknd 12790 11 pre pre JJ cord-010119-t1x9gknd 12790 12 and and CC cord-010119-t1x9gknd 12790 13 post post JJ cord-010119-t1x9gknd 12790 14 processes process NNS cord-010119-t1x9gknd 12790 15 . . . cord-010119-t1x9gknd 12791 1 Results/ Results/ . cord-010119-t1x9gknd 12792 1 Finding finding NN cord-010119-t1x9gknd 12792 2 : : : cord-010119-t1x9gknd 12793 1 Baseline baseline JJ cord-010119-t1x9gknd 12793 2 data datum NNS cord-010119-t1x9gknd 12793 3 shows show VBZ cord-010119-t1x9gknd 12793 4 that that IN cord-010119-t1x9gknd 12793 5 the the DT cord-010119-t1x9gknd 12793 6 ED ED NNP cord-010119-t1x9gknd 12793 7 requested request VBD cord-010119-t1x9gknd 12793 8 an an DT cord-010119-t1x9gknd 12793 9 average average NN cord-010119-t1x9gknd 12793 10 of of IN cord-010119-t1x9gknd 12793 11 99 99 CD cord-010119-t1x9gknd 12793 12 RBC RBC NNP cord-010119-t1x9gknd 12793 13 / / SYM cord-010119-t1x9gknd 12793 14 month month NN cord-010119-t1x9gknd 12793 15 in in IN cord-010119-t1x9gknd 12793 16 coolers cooler NNS cord-010119-t1x9gknd 12793 17 . . . cord-010119-t1x9gknd 12794 1 Post post NN cord-010119-t1x9gknd 12794 2 change change NN cord-010119-t1x9gknd 12795 1 this this DT cord-010119-t1x9gknd 12795 2 dropped drop VBD cord-010119-t1x9gknd 12795 3 to to IN cord-010119-t1x9gknd 12795 4 62 62 CD cord-010119-t1x9gknd 12795 5 RBC RBC NNP cord-010119-t1x9gknd 12795 6 / / SYM cord-010119-t1x9gknd 12795 7 month month NN cord-010119-t1x9gknd 12795 8 , , , cord-010119-t1x9gknd 12795 9 thus thus RB cord-010119-t1x9gknd 12795 10 less less JJR cord-010119-t1x9gknd 12795 11 blood blood NN cord-010119-t1x9gknd 12795 12 was be VBD cord-010119-t1x9gknd 12795 13 requested request VBN cord-010119-t1x9gknd 12795 14 from from IN cord-010119-t1x9gknd 12795 15 the the DT cord-010119-t1x9gknd 12795 16 transfusion transfusion NN cord-010119-t1x9gknd 12795 17 service service NN cord-010119-t1x9gknd 12795 18 in in IN cord-010119-t1x9gknd 12795 19 coolers cooler NNS cord-010119-t1x9gknd 12795 20 as as IN cord-010119-t1x9gknd 12795 21 units unit NNS cord-010119-t1x9gknd 12795 22 were be VBD cord-010119-t1x9gknd 12795 23 being be VBG cord-010119-t1x9gknd 12795 24 used use VBN cord-010119-t1x9gknd 12795 25 from from IN cord-010119-t1x9gknd 12795 26 the the DT cord-010119-t1x9gknd 12795 27 fridge fridge NN cord-010119-t1x9gknd 12795 28 . . . cord-010119-t1x9gknd 12796 1 Baseline baseline JJ cord-010119-t1x9gknd 12796 2 data datum NNS cord-010119-t1x9gknd 12796 3 also also RB cord-010119-t1x9gknd 12796 4 shows show VBZ cord-010119-t1x9gknd 12796 5 that that IN cord-010119-t1x9gknd 12796 6 an an DT cord-010119-t1x9gknd 12796 7 average average NN cord-010119-t1x9gknd 12796 8 of of IN cord-010119-t1x9gknd 12796 9 54 54 CD cord-010119-t1x9gknd 12796 10 RBC RBC NNP cord-010119-t1x9gknd 12796 11 / / SYM cord-010119-t1x9gknd 12796 12 month month NN cord-010119-t1x9gknd 12796 13 were be VBD cord-010119-t1x9gknd 12796 14 returned return VBN cord-010119-t1x9gknd 12796 15 ( ( -LRB- cord-010119-t1x9gknd 12796 16 55 55 CD cord-010119-t1x9gknd 12796 17 % % NN cord-010119-t1x9gknd 12796 18 ) ) -RRB- cord-010119-t1x9gknd 12796 19 . . . cord-010119-t1x9gknd 12797 1 Post post JJ cord-010119-t1x9gknd 12797 2 change change NN cord-010119-t1x9gknd 12797 3 , , , cord-010119-t1x9gknd 12797 4 the the DT cord-010119-t1x9gknd 12797 5 average average JJ cord-010119-t1x9gknd 12797 6 RBC/ RBC/ NNP cord-010119-t1x9gknd 12797 7 month month NN cord-010119-t1x9gknd 12797 8 returned return VBD cord-010119-t1x9gknd 12797 9 was be VBD cord-010119-t1x9gknd 12797 10 27 27 CD cord-010119-t1x9gknd 12797 11 ( ( -LRB- cord-010119-t1x9gknd 12797 12 44 44 CD cord-010119-t1x9gknd 12797 13 % % NN cord-010119-t1x9gknd 12797 14 ) ) -RRB- cord-010119-t1x9gknd 12797 15 , , , cord-010119-t1x9gknd 12797 16 this this DT cord-010119-t1x9gknd 12797 17 represents represent VBZ cord-010119-t1x9gknd 12797 18 an an DT cord-010119-t1x9gknd 12797 19 absolute absolute JJ cord-010119-t1x9gknd 12797 20 50 50 CD cord-010119-t1x9gknd 12797 21 % % NN cord-010119-t1x9gknd 12797 22 reduction reduction NN cord-010119-t1x9gknd 12797 23 in in IN cord-010119-t1x9gknd 12797 24 number number NN cord-010119-t1x9gknd 12797 25 of of IN cord-010119-t1x9gknd 12797 26 returned return VBN cord-010119-t1x9gknd 12797 27 products product NNS cord-010119-t1x9gknd 12797 28 . . . cord-010119-t1x9gknd 12798 1 Each each DT cord-010119-t1x9gknd 12798 2 RBC RBC NNP cord-010119-t1x9gknd 12798 3 dispensed dispense VBD cord-010119-t1x9gknd 12798 4 and and CC cord-010119-t1x9gknd 12798 5 returned return VBD cord-010119-t1x9gknd 12798 6 takes take VBZ cord-010119-t1x9gknd 12798 7 approximately approximately RB cord-010119-t1x9gknd 12798 8 20 20 CD cord-010119-t1x9gknd 12798 9 minutes minute NNS cord-010119-t1x9gknd 12798 10 to to TO cord-010119-t1x9gknd 12798 11 complete complete VB cord-010119-t1x9gknd 12798 12 paperwork paperwork NN cord-010119-t1x9gknd 12798 13 and and CC cord-010119-t1x9gknd 12798 14 transport transport NN cord-010119-t1x9gknd 12798 15 , , , cord-010119-t1x9gknd 12798 16 therefore therefore RB cord-010119-t1x9gknd 12798 17 this this DT cord-010119-t1x9gknd 12798 18 change change NN cord-010119-t1x9gknd 12798 19 saved save VBD cord-010119-t1x9gknd 12798 20 an an DT cord-010119-t1x9gknd 12798 21 average average NN cord-010119-t1x9gknd 12798 22 of of IN cord-010119-t1x9gknd 12798 23 540 540 CD cord-010119-t1x9gknd 12798 24 minutes minute NNS cord-010119-t1x9gknd 12798 25 per per IN cord-010119-t1x9gknd 12798 26 month month NN cord-010119-t1x9gknd 12798 27 . . . cord-010119-t1x9gknd 12799 1 It -PRON- PRP cord-010119-t1x9gknd 12799 2 was be VBD cord-010119-t1x9gknd 12799 3 also also RB cord-010119-t1x9gknd 12799 4 noted note VBN cord-010119-t1x9gknd 12799 5 that that IN cord-010119-t1x9gknd 12799 6 the the DT cord-010119-t1x9gknd 12799 7 average average JJ cord-010119-t1x9gknd 12799 8 RBC RBC NNP cord-010119-t1x9gknd 12799 9 / / SYM cord-010119-t1x9gknd 12799 10 month month NN cord-010119-t1x9gknd 12799 11 transfused transfuse VBN cord-010119-t1x9gknd 12799 12 was be VBD cord-010119-t1x9gknd 12799 13 44 44 CD cord-010119-t1x9gknd 12799 14 for for IN cord-010119-t1x9gknd 12799 15 baseline baseline NN cord-010119-t1x9gknd 12799 16 and and CC cord-010119-t1x9gknd 12799 17 57 57 CD cord-010119-t1x9gknd 12799 18 post post NN cord-010119-t1x9gknd 12799 19 change change NN cord-010119-t1x9gknd 12799 20 . . . cord-010119-t1x9gknd 12800 1 This this DT cord-010119-t1x9gknd 12800 2 confirms confirm VBZ cord-010119-t1x9gknd 12800 3 that that IN cord-010119-t1x9gknd 12800 4 the the DT cord-010119-t1x9gknd 12800 5 decreased decrease VBN cord-010119-t1x9gknd 12800 6 requests request NNS cord-010119-t1x9gknd 12800 7 and and CC cord-010119-t1x9gknd 12800 8 returns return NNS cord-010119-t1x9gknd 12800 9 were be VBD cord-010119-t1x9gknd 12800 10 not not RB cord-010119-t1x9gknd 12800 11 due due JJ cord-010119-t1x9gknd 12800 12 to to IN cord-010119-t1x9gknd 12800 13 decreased decrease VBN cord-010119-t1x9gknd 12800 14 patient patient JJ cord-010119-t1x9gknd 12800 15 volume volume NN cord-010119-t1x9gknd 12800 16 or or CC cord-010119-t1x9gknd 12800 17 severity severity NN cord-010119-t1x9gknd 12800 18 . . . cord-010119-t1x9gknd 12801 1 The the DT cord-010119-t1x9gknd 12801 2 fridge fridge NN cord-010119-t1x9gknd 12801 3 was be VBD cord-010119-t1x9gknd 12801 4 also also RB cord-010119-t1x9gknd 12801 5 successful successful JJ cord-010119-t1x9gknd 12801 6 at at IN cord-010119-t1x9gknd 12801 7 decreasing decrease VBG cord-010119-t1x9gknd 12801 8 delivery delivery NN cord-010119-t1x9gknd 12801 9 time time NN cord-010119-t1x9gknd 12801 10 of of IN cord-010119-t1x9gknd 12801 11 blood blood NN cord-010119-t1x9gknd 12801 12 to to IN cord-010119-t1x9gknd 12801 13 patient patient JJ cord-010119-t1x9gknd 12801 14 bedside bedside NN cord-010119-t1x9gknd 12801 15 , , , cord-010119-t1x9gknd 12801 16 as as IN cord-010119-t1x9gknd 12801 17 baseline baseline JJ cord-010119-t1x9gknd 12801 18 delivery delivery NN cord-010119-t1x9gknd 12801 19 time time NN cord-010119-t1x9gknd 12801 20 of of IN cord-010119-t1x9gknd 12801 21 15 15 CD cord-010119-t1x9gknd 12801 22 - - SYM cord-010119-t1x9gknd 12801 23 20 20 CD cord-010119-t1x9gknd 12801 24 minutes minute NNS cord-010119-t1x9gknd 12801 25 ( ( -LRB- cord-010119-t1x9gknd 12801 26 estimated estimate VBN cord-010119-t1x9gknd 12801 27 ) ) -RRB- cord-010119-t1x9gknd 12801 28 was be VBD cord-010119-t1x9gknd 12801 29 reduced reduce VBN cord-010119-t1x9gknd 12801 30 to to IN cord-010119-t1x9gknd 12801 31 3 3 CD cord-010119-t1x9gknd 12801 32 - - SYM cord-010119-t1x9gknd 12801 33 5 5 CD cord-010119-t1x9gknd 12801 34 minutes minute NNS cord-010119-t1x9gknd 12801 35 . . . cord-010119-t1x9gknd 12802 1 Conclusion conclusion NN cord-010119-t1x9gknd 12802 2 : : : cord-010119-t1x9gknd 12802 3 Implementing implement VBG cord-010119-t1x9gknd 12802 4 a a DT cord-010119-t1x9gknd 12802 5 remote remote JJ cord-010119-t1x9gknd 12802 6 blood blood NN cord-010119-t1x9gknd 12802 7 fridge fridge NN cord-010119-t1x9gknd 12802 8 and and CC cord-010119-t1x9gknd 12802 9 moving move VBG cord-010119-t1x9gknd 12802 10 blood blood NN cord-010119-t1x9gknd 12802 11 access access NN cord-010119-t1x9gknd 12802 12 closer close RBR cord-010119-t1x9gknd 12802 13 to to IN cord-010119-t1x9gknd 12802 14 patient patient JJ cord-010119-t1x9gknd 12802 15 bedside bedside NN cord-010119-t1x9gknd 12802 16 ensures ensure VBZ cord-010119-t1x9gknd 12802 17 a a DT cord-010119-t1x9gknd 12802 18 faster fast JJR cord-010119-t1x9gknd 12802 19 delivery delivery NN cord-010119-t1x9gknd 12802 20 of of IN cord-010119-t1x9gknd 12802 21 blood blood NN cord-010119-t1x9gknd 12802 22 to to IN cord-010119-t1x9gknd 12802 23 the the DT cord-010119-t1x9gknd 12802 24 patient patient NN cord-010119-t1x9gknd 12802 25 . . . cord-010119-t1x9gknd 12803 1 This this DT cord-010119-t1x9gknd 12803 2 change change NN cord-010119-t1x9gknd 12803 3 has have VBZ cord-010119-t1x9gknd 12803 4 an an DT cord-010119-t1x9gknd 12803 5 additional additional JJ cord-010119-t1x9gknd 12803 6 benefit benefit NN cord-010119-t1x9gknd 12803 7 of of IN cord-010119-t1x9gknd 12803 8 decreasing decrease VBG cord-010119-t1x9gknd 12803 9 wasted waste VBN cord-010119-t1x9gknd 12803 10 time time NN cord-010119-t1x9gknd 12803 11 , , , cord-010119-t1x9gknd 12803 12 and and CC cord-010119-t1x9gknd 12803 13 hence hence RB cord-010119-t1x9gknd 12803 14 cost cost VB cord-010119-t1x9gknd 12803 15 , , , cord-010119-t1x9gknd 12803 16 by by IN cord-010119-t1x9gknd 12803 17 decreasing decrease VBG cord-010119-t1x9gknd 12803 18 unnecessary unnecessary JJ cord-010119-t1x9gknd 12803 19 product product NN cord-010119-t1x9gknd 12803 20 requests request NNS cord-010119-t1x9gknd 12803 21 and and CC cord-010119-t1x9gknd 12803 22 returns return NNS cord-010119-t1x9gknd 12803 23 . . . cord-010119-t1x9gknd 12804 1 Implementing implement VBG cord-010119-t1x9gknd 12804 2 a a DT cord-010119-t1x9gknd 12804 3 blood blood NN cord-010119-t1x9gknd 12804 4 fridge fridge NN cord-010119-t1x9gknd 12804 5 can can MD cord-010119-t1x9gknd 12804 6 also also RB cord-010119-t1x9gknd 12804 7 be be VB cord-010119-t1x9gknd 12804 8 done do VBN cord-010119-t1x9gknd 12804 9 at at IN cord-010119-t1x9gknd 12804 10 a a DT cord-010119-t1x9gknd 12804 11 reduced reduce VBN cord-010119-t1x9gknd 12804 12 cost cost NN cord-010119-t1x9gknd 12804 13 through through IN cord-010119-t1x9gknd 12804 14 homegrown homegrown JJ cord-010119-t1x9gknd 12804 15 processes process NNS cord-010119-t1x9gknd 12804 16 . . . cord-010119-t1x9gknd 12805 1 Transfusions transfusion NNS cord-010119-t1x9gknd 12805 2 are be VBP cord-010119-t1x9gknd 12805 3 everyday everyday JJ cord-010119-t1x9gknd 12805 4 procedures procedure NNS cord-010119-t1x9gknd 12805 5 and and CC cord-010119-t1x9gknd 12805 6 over over IN cord-010119-t1x9gknd 12805 7 250 250 CD cord-010119-t1x9gknd 12805 8 Patent Patent NNP cord-010119-t1x9gknd 12805 9 - - HYPH cord-010119-t1x9gknd 12805 10 applications application NNS cord-010119-t1x9gknd 12805 11 have have VBP cord-010119-t1x9gknd 12805 12 been be VBN cord-010119-t1x9gknd 12805 13 filed file VBN cord-010119-t1x9gknd 12805 14 related relate VBN cord-010119-t1x9gknd 12805 15 to to IN cord-010119-t1x9gknd 12805 16 " " `` cord-010119-t1x9gknd 12805 17 Transfusion Transfusion NNP cord-010119-t1x9gknd 12805 18 Medicine Medicine NNP cord-010119-t1x9gknd 12805 19 " " '' cord-010119-t1x9gknd 12805 20 and and CC cord-010119-t1x9gknd 12805 21 over over IN cord-010119-t1x9gknd 12805 22 400 400 CD cord-010119-t1x9gknd 12805 23 related relate VBN cord-010119-t1x9gknd 12805 24 to to IN cord-010119-t1x9gknd 12805 25 " " `` cord-010119-t1x9gknd 12805 26 Transfusion Transfusion NNP cord-010119-t1x9gknd 12805 27 Alarm Alarm NNP cord-010119-t1x9gknd 12805 28 " " '' cord-010119-t1x9gknd 12805 29 , , , cord-010119-t1x9gknd 12805 30 during during IN cord-010119-t1x9gknd 12805 31 the the DT cord-010119-t1x9gknd 12805 32 last last JJ cord-010119-t1x9gknd 12805 33 30 30 CD cord-010119-t1x9gknd 12805 34 years year NNS cord-010119-t1x9gknd 12805 35 , , , cord-010119-t1x9gknd 12805 36 employing employ VBG cord-010119-t1x9gknd 12805 37 numerous numerous JJ cord-010119-t1x9gknd 12805 38 technical technical JJ cord-010119-t1x9gknd 12805 39 settings setting NNS cord-010119-t1x9gknd 12805 40 , , , cord-010119-t1x9gknd 12805 41 aiming aim VBG cord-010119-t1x9gknd 12805 42 to to TO cord-010119-t1x9gknd 12805 43 support support VB cord-010119-t1x9gknd 12805 44 automated automated JJ cord-010119-t1x9gknd 12805 45 supervision supervision NN cord-010119-t1x9gknd 12805 46 of of IN cord-010119-t1x9gknd 12805 47 the the DT cord-010119-t1x9gknd 12805 48 mentioned mention VBN cord-010119-t1x9gknd 12805 49 actions action NNS cord-010119-t1x9gknd 12805 50 . . . cord-010119-t1x9gknd 12806 1 The the DT cord-010119-t1x9gknd 12806 2 aim aim NN cord-010119-t1x9gknd 12806 3 of of IN cord-010119-t1x9gknd 12806 4 this this DT cord-010119-t1x9gknd 12806 5 contribution contribution NN cord-010119-t1x9gknd 12806 6 is be VBZ cord-010119-t1x9gknd 12806 7 to to TO cord-010119-t1x9gknd 12806 8 present present VB cord-010119-t1x9gknd 12806 9 a a DT cord-010119-t1x9gknd 12806 10 developed develop VBN cord-010119-t1x9gknd 12806 11 low low JJ cord-010119-t1x9gknd 12806 12 - - HYPH cord-010119-t1x9gknd 12806 13 cost cost NN cord-010119-t1x9gknd 12806 14 real real JJ cord-010119-t1x9gknd 12806 15 - - HYPH cord-010119-t1x9gknd 12806 16 time time NN cord-010119-t1x9gknd 12806 17 individual individual JJ cord-010119-t1x9gknd 12806 18 Intravenous Intravenous NNP cord-010119-t1x9gknd 12806 19 Blood Blood NNP cord-010119-t1x9gknd 12806 20 - - HYPH cord-010119-t1x9gknd 12806 21 Transfusion transfusion NN cord-010119-t1x9gknd 12806 22 monitoring monitoring NN cord-010119-t1x9gknd 12806 23 system system NN cord-010119-t1x9gknd 12806 24 , , , cord-010119-t1x9gknd 12806 25 based base VBN cord-010119-t1x9gknd 12806 26 on on IN cord-010119-t1x9gknd 12806 27 the the DT cord-010119-t1x9gknd 12806 28 Internet internet NN cord-010119-t1x9gknd 12806 29 of of IN cord-010119-t1x9gknd 12806 30 Things thing NNS cord-010119-t1x9gknd 12806 31 . . . cord-010119-t1x9gknd 12807 1 Study Study NNP cord-010119-t1x9gknd 12807 2 Design Design NNP cord-010119-t1x9gknd 12807 3 / / SYM cord-010119-t1x9gknd 12807 4 Method method NN cord-010119-t1x9gknd 12807 5 : : : cord-010119-t1x9gknd 12808 1 The the DT cord-010119-t1x9gknd 12808 2 designed design VBN cord-010119-t1x9gknd 12808 3 system system NN cord-010119-t1x9gknd 12808 4 is be VBZ cord-010119-t1x9gknd 12808 5 based base VBN cord-010119-t1x9gknd 12808 6 on on IN cord-010119-t1x9gknd 12808 7 a a DT cord-010119-t1x9gknd 12808 8 commercially commercially RB cord-010119-t1x9gknd 12808 9 available available JJ cord-010119-t1x9gknd 12808 10 Pan pan JJ cord-010119-t1x9gknd 12808 11 - - HYPH cord-010119-t1x9gknd 12808 12 Tilt Tilt NNP cord-010119-t1x9gknd 12808 13 - - HYPH cord-010119-t1x9gknd 12808 14 Zoom Zoom NNP cord-010119-t1x9gknd 12808 15 ( ( -LRB- cord-010119-t1x9gknd 12808 16 PTZ ptz NN cord-010119-t1x9gknd 12808 17 ) ) -RRB- cord-010119-t1x9gknd 12808 18 camera camera NN cord-010119-t1x9gknd 12808 19 , , , cord-010119-t1x9gknd 12808 20 employing employ VBG cord-010119-t1x9gknd 12808 21 an an DT cord-010119-t1x9gknd 12808 22 1/4 1/4 CD cord-010119-t1x9gknd 12808 23 inch inch NN cord-010119-t1x9gknd 12808 24 color color NN cord-010119-t1x9gknd 12808 25 CMOS CMOS NNP cord-010119-t1x9gknd 12808 26 Sensor Sensor NNP cord-010119-t1x9gknd 12808 27 , , , cord-010119-t1x9gknd 12808 28 providing provide VBG cord-010119-t1x9gknd 12808 29 effectively effectively RB cord-010119-t1x9gknd 12808 30 1.0 1.0 CD cord-010119-t1x9gknd 12808 31 MP MP NNP cord-010119-t1x9gknd 12808 32 , , , cord-010119-t1x9gknd 12808 33 a a DT cord-010119-t1x9gknd 12808 34 3.6 3.6 CD cord-010119-t1x9gknd 12808 35 mm mm NNP cord-010119-t1x9gknd 12808 36 Lens Lens NNP cord-010119-t1x9gknd 12808 37 , , , cord-010119-t1x9gknd 12808 38 IR IR NNP cord-010119-t1x9gknd 12808 39 - - HYPH cord-010119-t1x9gknd 12808 40 cut cut VBN cord-010119-t1x9gknd 12808 41 , , , cord-010119-t1x9gknd 12808 42 Day Day NNP cord-010119-t1x9gknd 12808 43 / / SYM cord-010119-t1x9gknd 12808 44 Night Night NNP cord-010119-t1x9gknd 12808 45 Minimum Minimum NNP cord-010119-t1x9gknd 12808 46 Illumination Illumination NNP cord-010119-t1x9gknd 12808 47 0.1 0.1 CD cord-010119-t1x9gknd 12808 48 Lux Lux NNP cord-010119-t1x9gknd 12808 49 / / SYM cord-010119-t1x9gknd 12808 50 F F NNP cord-010119-t1x9gknd 12808 51 1 1 CD cord-010119-t1x9gknd 12808 52 and and CC cord-010119-t1x9gknd 12808 53 808 808 CD cord-010119-t1x9gknd 12808 54 Viewing viewing NN cord-010119-t1x9gknd 12808 55 Angle angle NN cord-010119-t1x9gknd 12808 56 . . . cord-010119-t1x9gknd 12809 1 The the DT cord-010119-t1x9gknd 12809 2 camera camera NN cord-010119-t1x9gknd 12809 3 is be VBZ cord-010119-t1x9gknd 12809 4 focused focus VBN cord-010119-t1x9gknd 12809 5 on on IN cord-010119-t1x9gknd 12809 6 the the DT cord-010119-t1x9gknd 12809 7 droplets droplet NNS cord-010119-t1x9gknd 12809 8 and and CC cord-010119-t1x9gknd 12809 9 acts act NNS cord-010119-t1x9gknd 12809 10 as as IN cord-010119-t1x9gknd 12809 11 VIS VIS NNP cord-010119-t1x9gknd 12809 12 / / SYM cord-010119-t1x9gknd 12809 13 IR IR NNP cord-010119-t1x9gknd 12809 14 Detector Detector NNP cord-010119-t1x9gknd 12809 15 with with IN cord-010119-t1x9gknd 12809 16 a a DT cord-010119-t1x9gknd 12809 17 24 24 CD cord-010119-t1x9gknd 12809 18 Hz Hz NNP cord-010119-t1x9gknd 12809 19 sampling sampling NN cord-010119-t1x9gknd 12809 20 - - HYPH cord-010119-t1x9gknd 12809 21 rate rate NN cord-010119-t1x9gknd 12809 22 . . . cord-010119-t1x9gknd 12810 1 Custom custom NN cord-010119-t1x9gknd 12810 2 - - HYPH cord-010119-t1x9gknd 12810 3 developed develop VBN cord-010119-t1x9gknd 12810 4 software software NN cord-010119-t1x9gknd 12810 5 supports support VBZ cord-010119-t1x9gknd 12810 6 droplets droplet NNS cord-010119-t1x9gknd 12810 7 ' ' POS cord-010119-t1x9gknd 12810 8 ratemonitoring ratemonitoring NN cord-010119-t1x9gknd 12810 9 , , , cord-010119-t1x9gknd 12810 10 causing cause VBG cord-010119-t1x9gknd 12810 11 acoustic acoustic JJ cord-010119-t1x9gknd 12810 12 alarm alarm NN cord-010119-t1x9gknd 12810 13 - - HYPH cord-010119-t1x9gknd 12810 14 signals signal NNS cord-010119-t1x9gknd 12810 15 if if IN cord-010119-t1x9gknd 12810 16 necessary necessary JJ cord-010119-t1x9gknd 12810 17 ( ( -LRB- cord-010119-t1x9gknd 12810 18 e.g. e.g. RB cord-010119-t1x9gknd 12810 19 clotting clotting NN cord-010119-t1x9gknd 12810 20 , , , cord-010119-t1x9gknd 12810 21 blood blood NN cord-010119-t1x9gknd 12810 22 260A 260a CD cord-010119-t1x9gknd 12810 23 TRANSFUSION transfusion NN cord-010119-t1x9gknd 12810 24 2017 2017 CD cord-010119-t1x9gknd 12810 25 Vol Vol NNP cord-010119-t1x9gknd 12810 26 . . . cord-010119-t1x9gknd 12811 1 57 57 CD cord-010119-t1x9gknd 12812 1 Supplement supplement NN cord-010119-t1x9gknd 12812 2 S3 s3 NN cord-010119-t1x9gknd 12813 1 ABSTRACT abstract JJ cord-010119-t1x9gknd 12813 2 or or CC cord-010119-t1x9gknd 12813 3 other other JJ cord-010119-t1x9gknd 12813 4 suspensions suspension NNS cord-010119-t1x9gknd 12813 5 depletion depletion NN cord-010119-t1x9gknd 12813 6 etc etc NN cord-010119-t1x9gknd 12813 7 . . . cord-010119-t1x9gknd 12813 8 ) ) -RRB- cord-010119-t1x9gknd 12814 1 and and CC cord-010119-t1x9gknd 12814 2 enables enable VBZ cord-010119-t1x9gknd 12814 3 , , , cord-010119-t1x9gknd 12814 4 if if IN cord-010119-t1x9gknd 12814 5 necessary necessary JJ cord-010119-t1x9gknd 12814 6 , , , cord-010119-t1x9gknd 12814 7 wide wide JJ cord-010119-t1x9gknd 12814 8 - - HYPH cord-010119-t1x9gknd 12814 9 angle angle NN cord-010119-t1x9gknd 12814 10 image image NN cord-010119-t1x9gknd 12814 11 - - HYPH cord-010119-t1x9gknd 12814 12 capturing capturing NN cord-010119-t1x9gknd 12814 13 . . . cord-010119-t1x9gknd 12815 1 The the DT cord-010119-t1x9gknd 12815 2 Video Video NNP cord-010119-t1x9gknd 12815 3 Image image NN cord-010119-t1x9gknd 12815 4 - - HYPH cord-010119-t1x9gknd 12815 5 Audio audio NN cord-010119-t1x9gknd 12815 6 Settings setting NNS cord-010119-t1x9gknd 12815 7 provide provide VBP cord-010119-t1x9gknd 12815 8 for for IN cord-010119-t1x9gknd 12815 9 Compression compression NN cord-010119-t1x9gknd 12815 10 H.264 H.264 NNP cord-010119-t1x9gknd 12815 11 , , , cord-010119-t1x9gknd 12815 12 Video video NN cord-010119-t1x9gknd 12815 13 Frame frame NN cord-010119-t1x9gknd 12815 14 Rate rate NN cord-010119-t1x9gknd 12815 15 ( ( -LRB- cord-010119-t1x9gknd 12815 16 FPS FPS NNP cord-010119-t1x9gknd 12815 17 ) ) -RRB- cord-010119-t1x9gknd 12815 18 1 1 CD cord-010119-t1x9gknd 12815 19 - - SYM cord-010119-t1x9gknd 12815 20 30 30 CD cord-010119-t1x9gknd 12815 21 / / SYM cord-010119-t1x9gknd 12815 22 s s NNS cord-010119-t1x9gknd 12815 23 , , , cord-010119-t1x9gknd 12816 1 Refresh refresh VB cord-010119-t1x9gknd 12816 2 Rate rate NN cord-010119-t1x9gknd 12816 3 50 50 CD cord-010119-t1x9gknd 12816 4 Hz Hz NNP cord-010119-t1x9gknd 12816 5 and and CC cord-010119-t1x9gknd 12816 6 Audio Audio NNP cord-010119-t1x9gknd 12816 7 Input Input NNP cord-010119-t1x9gknd 12816 8 , , , cord-010119-t1x9gknd 12816 9 through through IN cord-010119-t1x9gknd 12816 10 bidirectional bidirectional JJ cord-010119-t1x9gknd 12816 11 built build VBN cord-010119-t1x9gknd 12816 12 - - HYPH cord-010119-t1x9gknd 12816 13 in in RP cord-010119-t1x9gknd 12816 14 Microphone Microphone NNP cord-010119-t1x9gknd 12816 15 . . . cord-010119-t1x9gknd 12817 1 The the DT cord-010119-t1x9gknd 12817 2 acquires acquire VBZ cord-010119-t1x9gknd 12817 3 an an DT cord-010119-t1x9gknd 12817 4 IP ip NN cord-010119-t1x9gknd 12817 5 - - HYPH cord-010119-t1x9gknd 12817 6 address address NN cord-010119-t1x9gknd 12818 1 , , , cord-010119-t1x9gknd 12818 2 the the DT cord-010119-t1x9gknd 12818 3 connection connection NN cord-010119-t1x9gknd 12818 4 mode mode NN cord-010119-t1x9gknd 12818 5 is be VBZ cord-010119-t1x9gknd 12818 6 Wireless Wireless NNP cord-010119-t1x9gknd 12818 7 , , , cord-010119-t1x9gknd 12818 8 the the DT cord-010119-t1x9gknd 12818 9 Network Network NNP cord-010119-t1x9gknd 12818 10 Interface Interface NNP cord-010119-t1x9gknd 12818 11 is be VBZ cord-010119-t1x9gknd 12818 12 Wi Wi NNP cord-010119-t1x9gknd 12818 13 - - HYPH cord-010119-t1x9gknd 12818 14 Fi/802.11 Fi/802.11 NNP cord-010119-t1x9gknd 12818 15 / / SYM cord-010119-t1x9gknd 12818 16 b b NN cord-010119-t1x9gknd 12818 17 / / SYM cord-010119-t1x9gknd 12818 18 g g NN cord-010119-t1x9gknd 12818 19 , , , cord-010119-t1x9gknd 12818 20 the the DT cord-010119-t1x9gknd 12818 21 supported support VBN cord-010119-t1x9gknd 12818 22 Protocols protocol NNS cord-010119-t1x9gknd 12818 23 include include VBP cord-010119-t1x9gknd 12818 24 DHCP DHCP NNP cord-010119-t1x9gknd 12818 25 , , , cord-010119-t1x9gknd 12818 26 TCP TCP NNP cord-010119-t1x9gknd 12818 27 / / SYM cord-010119-t1x9gknd 12818 28 IP IP NNP cord-010119-t1x9gknd 12818 29 , , , cord-010119-t1x9gknd 12818 30 UPNP UPNP NNP cord-010119-t1x9gknd 12818 31 , , , cord-010119-t1x9gknd 12818 32 HTTP HTTP NNP cord-010119-t1x9gknd 12818 33 , , , cord-010119-t1x9gknd 12818 34 SMTP SMTP NNP cord-010119-t1x9gknd 12818 35 and and CC cord-010119-t1x9gknd 12818 36 P2P p2p NN cord-010119-t1x9gknd 12818 37 is be VBZ cord-010119-t1x9gknd 12818 38 provided provide VBN cord-010119-t1x9gknd 12818 39 . . . cord-010119-t1x9gknd 12819 1 Typical typical JJ cord-010119-t1x9gknd 12819 2 5V 5V NNP cord-010119-t1x9gknd 12819 3 Power Power NNP cord-010119-t1x9gknd 12819 4 - - HYPH cord-010119-t1x9gknd 12819 5 Supply Supply NNP cord-010119-t1x9gknd 12819 6 , , , cord-010119-t1x9gknd 12819 7 sized sized JJ cord-010119-t1x9gknd 12819 8 165x125x101 165x125x101 CD cord-010119-t1x9gknd 12819 9 mm mm NNS cord-010119-t1x9gknd 12819 10 and and CC cord-010119-t1x9gknd 12819 11 weighing weighing NN cord-010119-t1x9gknd 12820 1 370 370 CD cord-010119-t1x9gknd 12820 2 g. g. NNP cord-010119-t1x9gknd 12820 3 Client Client NNP cord-010119-t1x9gknd 12820 4 Software Software NNP cord-010119-t1x9gknd 12820 5 is be VBZ cord-010119-t1x9gknd 12820 6 required require VBN cord-010119-t1x9gknd 12820 7 . . . cord-010119-t1x9gknd 12821 1 The the DT cord-010119-t1x9gknd 12821 2 IR IR NNP cord-010119-t1x9gknd 12821 3 range range NN cord-010119-t1x9gknd 12821 4 is be VBZ cord-010119-t1x9gknd 12821 5 10 10 CD cord-010119-t1x9gknd 12821 6 - - SYM cord-010119-t1x9gknd 12821 7 15 15 CD cord-010119-t1x9gknd 12821 8 m m NN cord-010119-t1x9gknd 12821 9 ; ; : cord-010119-t1x9gknd 12821 10 IR IR NNP cord-010119-t1x9gknd 12821 11 - - HYPH cord-010119-t1x9gknd 12821 12 Cut Cut VBN cord-010119-t1x9gknd 12821 13 Filters Filters NNPS cord-010119-t1x9gknd 12821 14 , , , cord-010119-t1x9gknd 12821 15 Remote Remote NNP cord-010119-t1x9gknd 12821 16 Access Access NNP cord-010119-t1x9gknd 12821 17 , , , cord-010119-t1x9gknd 12821 18 Dual Dual NNP cord-010119-t1x9gknd 12821 19 Stream Stream NNP cord-010119-t1x9gknd 12821 20 , , , cord-010119-t1x9gknd 12821 21 Motion Motion NNP cord-010119-t1x9gknd 12821 22 Detection Detection NNP cord-010119-t1x9gknd 12821 23 , , , cord-010119-t1x9gknd 12821 24 Day Day NNP cord-010119-t1x9gknd 12821 25 / / SYM cord-010119-t1x9gknd 12821 26 Night Night NNP cord-010119-t1x9gknd 12821 27 and and CC cord-010119-t1x9gknd 12821 28 IR IR NNP cord-010119-t1x9gknd 12821 29 Night Night NNP cord-010119-t1x9gknd 12821 30 Vision Vision NNP cord-010119-t1x9gknd 12821 31 Distance Distance NNP cord-010119-t1x9gknd 12821 32 of of IN cord-010119-t1x9gknd 12821 33 10 10 CD cord-010119-t1x9gknd 12821 34 m m NNS cord-010119-t1x9gknd 12821 35 are be VBP cord-010119-t1x9gknd 12821 36 offered offer VBN cord-010119-t1x9gknd 12821 37 . . . cord-010119-t1x9gknd 12822 1 Two two CD cord-010119-t1x9gknd 12822 2 - - HYPH cord-010119-t1x9gknd 12822 3 way way NN cord-010119-t1x9gknd 12822 4 radio radio NN cord-010119-t1x9gknd 12822 5 - - HYPH cord-010119-t1x9gknd 12822 6 link link NN cord-010119-t1x9gknd 12822 7 is be VBZ cord-010119-t1x9gknd 12822 8 provided provide VBN cord-010119-t1x9gknd 12822 9 , , , cord-010119-t1x9gknd 12822 10 as as RB cord-010119-t1x9gknd 12822 11 well well RB cord-010119-t1x9gknd 12822 12 as as IN cord-010119-t1x9gknd 12822 13 , , , cord-010119-t1x9gknd 12822 14 Trans Trans NNP cord-010119-t1x9gknd 12822 15 - - NNP cord-010119-t1x9gknd 12822 16 Flash Flash NNP cord-010119-t1x9gknd 12822 17 ( ( -LRB- cord-010119-t1x9gknd 12822 18 TF TF NNP cord-010119-t1x9gknd 12822 19 ) ) -RRB- cord-010119-t1x9gknd 12822 20 recording recording NN cord-010119-t1x9gknd 12822 21 and and CC cord-010119-t1x9gknd 12822 22 storage storage NN cord-010119-t1x9gknd 12822 23 on on IN cord-010119-t1x9gknd 12822 24 a a DT cord-010119-t1x9gknd 12822 25 32 32 CD cord-010119-t1x9gknd 12822 26 GB GB NNP cord-010119-t1x9gknd 12822 27 SD SD NNP cord-010119-t1x9gknd 12822 28 - - HYPH cord-010119-t1x9gknd 12822 29 Card card NN cord-010119-t1x9gknd 12822 30 . . . cord-010119-t1x9gknd 12823 1 Pan Pan NNP cord-010119-t1x9gknd 12823 2 / / SYM cord-010119-t1x9gknd 12823 3 Tilt Tilt NNP cord-010119-t1x9gknd 12823 4 - - HYPH cord-010119-t1x9gknd 12823 5 Horizontal Horizontal NNP cord-010119-t1x9gknd 12823 6 355 355 CD cord-010119-t1x9gknd 12823 7 o o NN cord-010119-t1x9gknd 12823 8 and and CC cord-010119-t1x9gknd 12823 9 Pan Pan NNP cord-010119-t1x9gknd 12823 10 / / SYM cord-010119-t1x9gknd 12823 11 Tilt Tilt NNP cord-010119-t1x9gknd 12823 12 - - HYPH cord-010119-t1x9gknd 12823 13 Vertical Vertical NNP cord-010119-t1x9gknd 12824 1 90 90 CD cord-010119-t1x9gknd 12824 2 o o NN cord-010119-t1x9gknd 12824 3 movements movement NNS cord-010119-t1x9gknd 12824 4 can can MD cord-010119-t1x9gknd 12824 5 be be VB cord-010119-t1x9gknd 12824 6 performed perform VBN cord-010119-t1x9gknd 12824 7 . . . cord-010119-t1x9gknd 12825 1 The the DT cord-010119-t1x9gknd 12825 2 system system NN cord-010119-t1x9gknd 12825 3 facilitates facilitate VBZ cord-010119-t1x9gknd 12825 4 , , , cord-010119-t1x9gknd 12825 5 if if IN cord-010119-t1x9gknd 12825 6 needed need VBN cord-010119-t1x9gknd 12825 7 , , , cord-010119-t1x9gknd 12825 8 also also RB cord-010119-t1x9gknd 12825 9 patient patient JJ cord-010119-t1x9gknd 12825 10 's 's POS cord-010119-t1x9gknd 12825 11 position position NN cord-010119-t1x9gknd 12825 12 monitoring monitoring NN cord-010119-t1x9gknd 12825 13 and and CC cord-010119-t1x9gknd 12825 14 readings reading NNS cord-010119-t1x9gknd 12825 15 of of IN cord-010119-t1x9gknd 12825 16 other other JJ cord-010119-t1x9gknd 12825 17 monitoring monitoring NN cord-010119-t1x9gknd 12825 18 displays display NNS cord-010119-t1x9gknd 12825 19 , , , cord-010119-t1x9gknd 12825 20 such such JJ cord-010119-t1x9gknd 12825 21 as as IN cord-010119-t1x9gknd 12825 22 NIBP NIBP NNP cord-010119-t1x9gknd 12825 23 , , , cord-010119-t1x9gknd 12825 24 ECG ECG NNP cord-010119-t1x9gknd 12825 25 , , , cord-010119-t1x9gknd 12825 26 and and CC cord-010119-t1x9gknd 12825 27 SPO SPO NNP cord-010119-t1x9gknd 12825 28 2 2 CD cord-010119-t1x9gknd 12825 29 , , , cord-010119-t1x9gknd 12825 30 if if IN cord-010119-t1x9gknd 12825 31 present present JJ cord-010119-t1x9gknd 12825 32 . . . cord-010119-t1x9gknd 12826 1 Results result NNS cord-010119-t1x9gknd 12826 2 / / SYM cord-010119-t1x9gknd 12826 3 Finding finding NN cord-010119-t1x9gknd 12826 4 : : : cord-010119-t1x9gknd 12827 1 The the DT cord-010119-t1x9gknd 12827 2 system system NN cord-010119-t1x9gknd 12827 3 and and CC cord-010119-t1x9gknd 12827 4 is be VBZ cord-010119-t1x9gknd 12827 5 being be VBG cord-010119-t1x9gknd 12827 6 presently presently RB cord-010119-t1x9gknd 12827 7 tested test VBN cord-010119-t1x9gknd 12827 8 in in IN cord-010119-t1x9gknd 12827 9 a a DT cord-010119-t1x9gknd 12827 10 laboratory laboratory NN cord-010119-t1x9gknd 12827 11 ( ( -LRB- cord-010119-t1x9gknd 12827 12 non non JJ cord-010119-t1x9gknd 12827 13 - - JJ cord-010119-t1x9gknd 12827 14 clinical clinical JJ cord-010119-t1x9gknd 12827 15 ) ) -RRB- cord-010119-t1x9gknd 12827 16 environment environment NN cord-010119-t1x9gknd 12827 17 , , , cord-010119-t1x9gknd 12827 18 by by IN cord-010119-t1x9gknd 12827 19 simulating simulate VBG cord-010119-t1x9gknd 12827 20 the the DT cord-010119-t1x9gknd 12827 21 virtual virtual JJ cord-010119-t1x9gknd 12827 22 patient patient NN cord-010119-t1x9gknd 12827 23 , , , cord-010119-t1x9gknd 12827 24 with with IN cord-010119-t1x9gknd 12827 25 a a DT cord-010119-t1x9gknd 12827 26 custommade custommade NN cord-010119-t1x9gknd 12827 27 " " `` cord-010119-t1x9gknd 12827 28 phantom phantom NN cord-010119-t1x9gknd 12827 29 " " '' cord-010119-t1x9gknd 12827 30 , , , cord-010119-t1x9gknd 12827 31 combining combine VBG cord-010119-t1x9gknd 12827 32 flow flow NN cord-010119-t1x9gknd 12827 33 - - HYPH cord-010119-t1x9gknd 12827 34 rate rate NN cord-010119-t1x9gknd 12827 35 , , , cord-010119-t1x9gknd 12827 36 negative negative JJ cord-010119-t1x9gknd 12827 37 pressure pressure NN cord-010119-t1x9gknd 12827 38 and and CC cord-010119-t1x9gknd 12827 39 viscosity viscosity NN cord-010119-t1x9gknd 12827 40 resistance resistance NN cord-010119-t1x9gknd 12827 41 regulation regulation NN cord-010119-t1x9gknd 12827 42 . . . cord-010119-t1x9gknd 12828 1 Conclusion conclusion NN cord-010119-t1x9gknd 12828 2 : : : cord-010119-t1x9gknd 12829 1 The the DT cord-010119-t1x9gknd 12829 2 system system NN cord-010119-t1x9gknd 12829 3 can can MD cord-010119-t1x9gknd 12829 4 measure measure VB cord-010119-t1x9gknd 12829 5 infusion infusion NN cord-010119-t1x9gknd 12829 6 - - HYPH cord-010119-t1x9gknd 12829 7 speed speed NN cord-010119-t1x9gknd 12829 8 with with IN cord-010119-t1x9gknd 12829 9 a a DT cord-010119-t1x9gknd 12829 10 deviation deviation NN cord-010119-t1x9gknd 12829 11 lower low JJR cord-010119-t1x9gknd 12829 12 than than IN cord-010119-t1x9gknd 12829 13 6 6 CD cord-010119-t1x9gknd 12829 14 3 3 CD cord-010119-t1x9gknd 12829 15 % % NN cord-010119-t1x9gknd 12829 16 . . . cord-010119-t1x9gknd 12830 1 The the DT cord-010119-t1x9gknd 12830 2 developed developed JJ cord-010119-t1x9gknd 12830 3 IoT iot NN cord-010119-t1x9gknd 12830 4 - - HYPH cord-010119-t1x9gknd 12830 5 system system NN cord-010119-t1x9gknd 12830 6 takes take VBZ cord-010119-t1x9gknd 12830 7 advantage advantage NN cord-010119-t1x9gknd 12830 8 of of IN cord-010119-t1x9gknd 12830 9 the the DT cord-010119-t1x9gknd 12830 10 existing exist VBG cord-010119-t1x9gknd 12830 11 Hospital Hospital NNP cord-010119-t1x9gknd 12830 12 Wi Wi NNP cord-010119-t1x9gknd 12830 13 - - HYPH cord-010119-t1x9gknd 12830 14 Fi Fi NNP cord-010119-t1x9gknd 12830 15 networked networked JJ cord-010119-t1x9gknd 12830 16 environment environment NN cord-010119-t1x9gknd 12830 17 and and CC cord-010119-t1x9gknd 12830 18 offers offer VBZ cord-010119-t1x9gknd 12830 19 a a DT cord-010119-t1x9gknd 12830 20 low low JJ cord-010119-t1x9gknd 12830 21 - - HYPH cord-010119-t1x9gknd 12830 22 cost cost NN cord-010119-t1x9gknd 12830 23 solution solution NN cord-010119-t1x9gknd 12830 24 , , , cord-010119-t1x9gknd 12830 25 under under IN cord-010119-t1x9gknd 12830 26 20 20 CD cord-010119-t1x9gknd 12830 27 $ $ $ cord-010119-t1x9gknd 12830 28 for for IN cord-010119-t1x9gknd 12830 29 each each DT cord-010119-t1x9gknd 12830 30 monitoring monitoring NN cord-010119-t1x9gknd 12830 31 - - HYPH cord-010119-t1x9gknd 12830 32 set set NN cord-010119-t1x9gknd 12830 33 . . . cord-010119-t1x9gknd 12831 1 It -PRON- PRP cord-010119-t1x9gknd 12831 2 allows allow VBZ cord-010119-t1x9gknd 12831 3 for for IN cord-010119-t1x9gknd 12831 4 even even RB cord-010119-t1x9gknd 12831 5 multi multi JJ cord-010119-t1x9gknd 12831 6 - - JJ cord-010119-t1x9gknd 12831 7 platform platform JJ cord-010119-t1x9gknd 12831 8 ( ( -LRB- cord-010119-t1x9gknd 12831 9 IOS IOS NNP cord-010119-t1x9gknd 12831 10 , , , cord-010119-t1x9gknd 12831 11 Android Android NNP cord-010119-t1x9gknd 12831 12 , , , cord-010119-t1x9gknd 12831 13 Windows Windows NNP cord-010119-t1x9gknd 12831 14 ) ) -RRB- cord-010119-t1x9gknd 12831 15 smart smart JJ cord-010119-t1x9gknd 12831 16 - - HYPH cord-010119-t1x9gknd 12831 17 phone phone NN cord-010119-t1x9gknd 12831 18 , , , cord-010119-t1x9gknd 12831 19 short short JJ cord-010119-t1x9gknd 12831 20 - - HYPH cord-010119-t1x9gknd 12831 21 range range NN cord-010119-t1x9gknd 12831 22 connectivity connectivity NN cord-010119-t1x9gknd 12831 23 , , , cord-010119-t1x9gknd 12831 24 for for IN cord-010119-t1x9gknd 12831 25 up up IN cord-010119-t1x9gknd 12831 26 to to TO cord-010119-t1x9gknd 12831 27 4 4 CD cord-010119-t1x9gknd 12831 28 participants participant NNS cord-010119-t1x9gknd 12831 29 , , , cord-010119-t1x9gknd 12831 30 for for IN cord-010119-t1x9gknd 12831 31 example example NN cord-010119-t1x9gknd 12831 32 Nurse nurse NN cord-010119-t1x9gknd 12831 33 , , , cord-010119-t1x9gknd 12831 34 Physician physician NN cord-010119-t1x9gknd 12831 35 etc etc FW cord-010119-t1x9gknd 12831 36 . . . cord-010119-t1x9gknd 12832 1 Two two CD cord-010119-t1x9gknd 12832 2 Potential potential JJ cord-010119-t1x9gknd 12832 3 Approaches approach NNS cord-010119-t1x9gknd 12832 4 for for IN cord-010119-t1x9gknd 12832 5 the the DT cord-010119-t1x9gknd 12832 6 Quality Quality NNP cord-010119-t1x9gknd 12832 7 Control Control NNP cord-010119-t1x9gknd 12832 8 of of IN cord-010119-t1x9gknd 12832 9 BacT BacT NNP cord-010119-t1x9gknd 12832 10 / / SYM cord-010119-t1x9gknd 12832 11 ALERTV ALERTV NNP cord-010119-t1x9gknd 12832 12 R r NN cord-010119-t1x9gknd 12832 13 Culture culture NN cord-010119-t1x9gknd 12832 14 Media medium NNS cord-010119-t1x9gknd 12832 15 Using use VBG cord-010119-t1x9gknd 12832 16 Various various JJ cord-010119-t1x9gknd 12832 17 BioBall BioBall NNP cord-010119-t1x9gknd 12832 18 TM TM NNP cord-010119-t1x9gknd 12832 19 Organism organism NN cord-010119-t1x9gknd 12832 20 Preparations Preparations NNPS cord-010119-t1x9gknd 12832 21 Patricia Patricia NNP cord-010119-t1x9gknd 12832 22 Rule Rule NNP cord-010119-t1x9gknd 12833 1 * * NFP cord-010119-t1x9gknd 12833 2 , , , cord-010119-t1x9gknd 12833 3 Michelle Michelle NNP cord-010119-t1x9gknd 12833 4 Keener Keener NNP cord-010119-t1x9gknd 12833 5 and and CC cord-010119-t1x9gknd 12833 6 Christine Christine NNP cord-010119-t1x9gknd 12833 7 Crawford Crawford NNP cord-010119-t1x9gknd 12833 8 . . . cord-010119-t1x9gknd 12834 1 bioMerieux bioMerieux NNP cord-010119-t1x9gknd 12834 2 Inc. Inc. NNP cord-010119-t1x9gknd 12834 3 Background Background NNP cord-010119-t1x9gknd 12834 4 / / SYM cord-010119-t1x9gknd 12834 5 Case Case NNP cord-010119-t1x9gknd 12834 6 Studies Studies NNPS cord-010119-t1x9gknd 12834 7 : : : cord-010119-t1x9gknd 12835 1 The the DT cord-010119-t1x9gknd 12835 2 BacT BacT NNP cord-010119-t1x9gknd 12835 3 / / SYM cord-010119-t1x9gknd 12835 4 ALERTV ALERTV NNP cord-010119-t1x9gknd 12835 5 R R NNP cord-010119-t1x9gknd 12835 6 BPA BPA NNP cord-010119-t1x9gknd 12835 7 and and CC cord-010119-t1x9gknd 12835 8 BPN BPN NNP cord-010119-t1x9gknd 12835 9 culture culture NN cord-010119-t1x9gknd 12835 10 bottles bottle NNS cord-010119-t1x9gknd 12835 11 are be VBP cord-010119-t1x9gknd 12835 12 used use VBN cord-010119-t1x9gknd 12835 13 with with IN cord-010119-t1x9gknd 12835 14 the the DT cord-010119-t1x9gknd 12835 15 BacT BacT NNP cord-010119-t1x9gknd 12835 16 / / SYM cord-010119-t1x9gknd 12835 17 ALERT ALERT NNP cord-010119-t1x9gknd 12835 18 Microbial Microbial NNP cord-010119-t1x9gknd 12835 19 Detection Detection NNP cord-010119-t1x9gknd 12835 20 System System NNP cord-010119-t1x9gknd 12835 21 for for IN cord-010119-t1x9gknd 12835 22 rapid rapid JJ cord-010119-t1x9gknd 12835 23 screening screening NN cord-010119-t1x9gknd 12835 24 and and CC cord-010119-t1x9gknd 12835 25 detection detection NN cord-010119-t1x9gknd 12835 26 of of IN cord-010119-t1x9gknd 12835 27 microbial microbial JJ cord-010119-t1x9gknd 12835 28 contamination contamination NN cord-010119-t1x9gknd 12835 29 in in IN cord-010119-t1x9gknd 12835 30 Leukocyte Leukocyte NNP cord-010119-t1x9gknd 12835 31 Reduced Reduced NNP cord-010119-t1x9gknd 12835 32 Apheresis Apheresis NNP cord-010119-t1x9gknd 12835 33 Platelets platelet NNS cord-010119-t1x9gknd 12835 34 ( ( -LRB- cord-010119-t1x9gknd 12835 35 LRAP LRAP NNP cord-010119-t1x9gknd 12835 36 ) ) -RRB- cord-010119-t1x9gknd 12835 37 . . . cord-010119-t1x9gknd 12836 1 Recent recent JJ cord-010119-t1x9gknd 12836 2 changes change NNS cord-010119-t1x9gknd 12836 3 in in IN cord-010119-t1x9gknd 12836 4 the the DT cord-010119-t1x9gknd 12836 5 CLIA CLIA NNP cord-010119-t1x9gknd 12836 6 quality quality NN cord-010119-t1x9gknd 12836 7 control control NNP cord-010119-t1x9gknd 12836 8 guidelines guideline NNS cord-010119-t1x9gknd 12836 9 and and CC cord-010119-t1x9gknd 12836 10 AABB AABB NNP cord-010119-t1x9gknd 12836 11 accreditation accreditation NN cord-010119-t1x9gknd 12836 12 program program NN cord-010119-t1x9gknd 12836 13 will will MD cord-010119-t1x9gknd 12836 14 require require VB cord-010119-t1x9gknd 12836 15 additional additional JJ cord-010119-t1x9gknd 12836 16 quality quality NN cord-010119-t1x9gknd 12836 17 control control NN cord-010119-t1x9gknd 12836 18 of of IN cord-010119-t1x9gknd 12836 19 manufactures manufacture NNS cord-010119-t1x9gknd 12836 20 media medium NNS cord-010119-t1x9gknd 12836 21 that that WDT cord-010119-t1x9gknd 12836 22 is be VBZ cord-010119-t1x9gknd 12836 23 both both DT cord-010119-t1x9gknd 12836 24 lot lot NN cord-010119-t1x9gknd 12836 25 specific specific JJ cord-010119-t1x9gknd 12836 26 and and CC cord-010119-t1x9gknd 12836 27 shipment shipment NN cord-010119-t1x9gknd 12836 28 specific specific JJ cord-010119-t1x9gknd 12836 29 to to TO cord-010119-t1x9gknd 12836 30 ensure ensure VB cord-010119-t1x9gknd 12836 31 recovery recovery NN cord-010119-t1x9gknd 12836 32 of of IN cord-010119-t1x9gknd 12836 33 bacterial bacterial JJ cord-010119-t1x9gknd 12836 34 growth growth NN cord-010119-t1x9gknd 12836 35 . . . cord-010119-t1x9gknd 12837 1 A a DT cord-010119-t1x9gknd 12837 2 study study NN cord-010119-t1x9gknd 12837 3 was be VBD cord-010119-t1x9gknd 12837 4 conducted conduct VBN cord-010119-t1x9gknd 12837 5 using use VBG cord-010119-t1x9gknd 12837 6 commercially commercially RB cord-010119-t1x9gknd 12837 7 prepared prepare VBN cord-010119-t1x9gknd 12837 8 organisms organism NNS cord-010119-t1x9gknd 12837 9 evaluating evaluate VBG cord-010119-t1x9gknd 12837 10 both both CC cord-010119-t1x9gknd 12837 11 a a DT cord-010119-t1x9gknd 12837 12 comprehensive comprehensive JJ cord-010119-t1x9gknd 12837 13 organism organism NN cord-010119-t1x9gknd 12837 14 panel panel NN cord-010119-t1x9gknd 12837 15 as as RB cord-010119-t1x9gknd 12837 16 well well RB cord-010119-t1x9gknd 12837 17 as as IN cord-010119-t1x9gknd 12837 18 a a DT cord-010119-t1x9gknd 12837 19 streamlined streamline VBN cord-010119-t1x9gknd 12837 20 method method NN cord-010119-t1x9gknd 12837 21 utilizing utilize VBG cord-010119-t1x9gknd 12837 22 only only RB cord-010119-t1x9gknd 12837 23 two two CD cord-010119-t1x9gknd 12837 24 organisms organism NNS cord-010119-t1x9gknd 12837 25 from from IN cord-010119-t1x9gknd 12837 26 the the DT cord-010119-t1x9gknd 12837 27 panel panel NN cord-010119-t1x9gknd 12837 28 . . . cord-010119-t1x9gknd 12838 1 Study Study NNP cord-010119-t1x9gknd 12838 2 Design Design NNP cord-010119-t1x9gknd 12838 3 / / SYM cord-010119-t1x9gknd 12838 4 Method method NN cord-010119-t1x9gknd 12838 5 : : : cord-010119-t1x9gknd 12839 1 The the DT cord-010119-t1x9gknd 12839 2 general general JJ cord-010119-t1x9gknd 12839 3 protocol protocol NN cord-010119-t1x9gknd 12839 4 consisted consist VBD cord-010119-t1x9gknd 12839 5 of of IN cord-010119-t1x9gknd 12839 6 three three CD cord-010119-t1x9gknd 12839 7 replicates replicate VBZ cord-010119-t1x9gknd 12839 8 each each DT cord-010119-t1x9gknd 12839 9 of of IN cord-010119-t1x9gknd 12839 10 each each DT cord-010119-t1x9gknd 12839 11 organism organism NN cord-010119-t1x9gknd 12839 12 inoculated inoculate VBD cord-010119-t1x9gknd 12839 13 into into IN cord-010119-t1x9gknd 12839 14 two two CD cord-010119-t1x9gknd 12839 15 lots lot NNS cord-010119-t1x9gknd 12839 16 each each DT cord-010119-t1x9gknd 12839 17 of of IN cord-010119-t1x9gknd 12839 18 BPA BPA NNP cord-010119-t1x9gknd 12839 19 and and CC cord-010119-t1x9gknd 12839 20 BPN BPN NNP cord-010119-t1x9gknd 12839 21 by by IN cord-010119-t1x9gknd 12839 22 two two CD cord-010119-t1x9gknd 12839 23 different different JJ cord-010119-t1x9gknd 12839 24 analyst analyst NN cord-010119-t1x9gknd 12839 25 . . . cord-010119-t1x9gknd 12840 1 The the DT cord-010119-t1x9gknd 12840 2 study study NN cord-010119-t1x9gknd 12840 3 was be VBD cord-010119-t1x9gknd 12840 4 two two CD cord-010119-t1x9gknd 12840 5 part part NN cord-010119-t1x9gknd 12840 6 in in IN cord-010119-t1x9gknd 12840 7 that that DT cord-010119-t1x9gknd 12840 8 Aspergillus aspergillus NN cord-010119-t1x9gknd 12840 9 brasiliensis brasiliensis NN cord-010119-t1x9gknd 12840 10 , , , cord-010119-t1x9gknd 12840 11 Candida Candida NNP cord-010119-t1x9gknd 12840 12 albicans albican NNS cord-010119-t1x9gknd 12840 13 , , , cord-010119-t1x9gknd 12840 14 Bacillus bacillus NN cord-010119-t1x9gknd 12840 15 subtilis subtili NNS cord-010119-t1x9gknd 12840 16 subsp subsp NN cord-010119-t1x9gknd 12840 17 . . . cord-010119-t1x9gknd 12841 1 spizizenii spizizenii NNP cord-010119-t1x9gknd 12841 2 , , , cord-010119-t1x9gknd 12841 3 Pseudomonas Pseudomonas NNP cord-010119-t1x9gknd 12841 4 aeruginosa aeruginosa NN cord-010119-t1x9gknd 12841 5 , , , cord-010119-t1x9gknd 12841 6 Escherichia Escherichia NNP cord-010119-t1x9gknd 12841 7 coli coli NNS cord-010119-t1x9gknd 12841 8 , , , cord-010119-t1x9gknd 12841 9 Clostridium clostridium NN cord-010119-t1x9gknd 12841 10 sporogenes sporogene NNS cord-010119-t1x9gknd 12841 11 , , , cord-010119-t1x9gknd 12841 12 Staphylococcus Staphylococcus NNP cord-010119-t1x9gknd 12841 13 aureus aureus NN cord-010119-t1x9gknd 12841 14 and and CC cord-010119-t1x9gknd 12841 15 Streptococcus streptococcus NN cord-010119-t1x9gknd 12841 16 pyogenes pyogene NNS cord-010119-t1x9gknd 12841 17 were be VBD cord-010119-t1x9gknd 12841 18 prepared prepare VBN cord-010119-t1x9gknd 12841 19 from from IN cord-010119-t1x9gknd 12841 20 BioBall BioBall NNP cord-010119-t1x9gknd 12841 21 SingleShot SingleShot NNP cord-010119-t1x9gknd 12841 22 ( ( -LRB- cord-010119-t1x9gknd 12841 23 30 30 CD cord-010119-t1x9gknd 12841 24 CFU CFU NNP cord-010119-t1x9gknd 12841 25 ) ) -RRB- cord-010119-t1x9gknd 12841 26 , , , cord-010119-t1x9gknd 12841 27 MultiShot MultiShot NNP cord-010119-t1x9gknd 12841 28 550 550 CD cord-010119-t1x9gknd 12841 29 CFU CFU NNP cord-010119-t1x9gknd 12841 30 or or CC cord-010119-t1x9gknd 12841 31 HighDose HighDose NNP cord-010119-t1x9gknd 12841 32 10 10 CD cord-010119-t1x9gknd 12841 33 K k NN cord-010119-t1x9gknd 12841 34 organism organism NN cord-010119-t1x9gknd 12841 35 preparations preparation NNS cord-010119-t1x9gknd 12841 36 at at IN cord-010119-t1x9gknd 12841 37 a a DT cord-010119-t1x9gknd 12841 38 low low JJ cord-010119-t1x9gknd 12841 39 level level NN cord-010119-t1x9gknd 12841 40 ( ( -LRB- cord-010119-t1x9gknd 12841 41 < < XX cord-010119-t1x9gknd 12841 42 50 50 CD cord-010119-t1x9gknd 12841 43 CFU CFU NNP cord-010119-t1x9gknd 12841 44 ) ) -RRB- cord-010119-t1x9gknd 12841 45 and and CC cord-010119-t1x9gknd 12841 46 evaluated evaluate VBD cord-010119-t1x9gknd 12841 47 on on IN cord-010119-t1x9gknd 12841 48 the the DT cord-010119-t1x9gknd 12841 49 same same JJ cord-010119-t1x9gknd 12841 50 day day NN cord-010119-t1x9gknd 12841 51 of of IN cord-010119-t1x9gknd 12841 52 preparation preparation NN cord-010119-t1x9gknd 12841 53 as as IN cord-010119-t1x9gknd 12841 54 method method NN cord-010119-t1x9gknd 12841 55 validation validation NN cord-010119-t1x9gknd 12841 56 . . . cord-010119-t1x9gknd 12842 1 The the DT cord-010119-t1x9gknd 12842 2 second second JJ cord-010119-t1x9gknd 12842 3 part part NN cord-010119-t1x9gknd 12842 4 of of IN cord-010119-t1x9gknd 12842 5 the the DT cord-010119-t1x9gknd 12842 6 study study NN cord-010119-t1x9gknd 12842 7 utilized utilize VBN cord-010119-t1x9gknd 12842 8 Escherichia Escherichia NNP cord-010119-t1x9gknd 12842 9 coli coli NNS cord-010119-t1x9gknd 12842 10 and and CC cord-010119-t1x9gknd 12842 11 Staphylococcus Staphylococcus NNP cord-010119-t1x9gknd 12842 12 aureus aureu NNS cord-010119-t1x9gknd 12842 13 prepared prepare VBN cord-010119-t1x9gknd 12842 14 and and CC cord-010119-t1x9gknd 12842 15 frozen freeze VBN cord-010119-t1x9gknd 12842 16 at at IN cord-010119-t1x9gknd 12842 17 a a DT cord-010119-t1x9gknd 12842 18 higher high JJR cord-010119-t1x9gknd 12842 19 level level NN cord-010119-t1x9gknd 12842 20 and and CC cord-010119-t1x9gknd 12842 21 then then RB cord-010119-t1x9gknd 12842 22 evaluted evalute VBN cord-010119-t1x9gknd 12842 23 over over IN cord-010119-t1x9gknd 12842 24 a a DT cord-010119-t1x9gknd 12842 25 14 14 CD cord-010119-t1x9gknd 12842 26 day day NN cord-010119-t1x9gknd 12842 27 study study NN cord-010119-t1x9gknd 12842 28 as as IN cord-010119-t1x9gknd 12842 29 a a DT cord-010119-t1x9gknd 12842 30 stream stream NN cord-010119-t1x9gknd 12842 31 line line NN cord-010119-t1x9gknd 12842 32 approach approach NN cord-010119-t1x9gknd 12842 33 to to IN cord-010119-t1x9gknd 12842 34 routine routine JJ cord-010119-t1x9gknd 12842 35 quality quality NN cord-010119-t1x9gknd 12842 36 control control NN cord-010119-t1x9gknd 12842 37 testing testing NN cord-010119-t1x9gknd 12842 38 of of IN cord-010119-t1x9gknd 12842 39 the the DT cord-010119-t1x9gknd 12842 40 BacT BacT NNP cord-010119-t1x9gknd 12842 41 / / SYM cord-010119-t1x9gknd 12842 42 ALERT alert NN cord-010119-t1x9gknd 12842 43 culture culture NN cord-010119-t1x9gknd 12842 44 bottles bottle NNS cord-010119-t1x9gknd 12842 45 . . . cord-010119-t1x9gknd 12843 1 Inoculation inoculation NN cord-010119-t1x9gknd 12843 2 preparations preparation NNS cord-010119-t1x9gknd 12843 3 were be VBD cord-010119-t1x9gknd 12843 4 enumerated enumerate VBN cord-010119-t1x9gknd 12843 5 in in IN cord-010119-t1x9gknd 12843 6 duplicate duplicate NN cord-010119-t1x9gknd 12843 7 to to TO cord-010119-t1x9gknd 12843 8 confirm confirm VB cord-010119-t1x9gknd 12843 9 the the DT cord-010119-t1x9gknd 12843 10 level level NN cord-010119-t1x9gknd 12843 11 at at IN cord-010119-t1x9gknd 12843 12 each each DT cord-010119-t1x9gknd 12843 13 inoculation inoculation NN cord-010119-t1x9gknd 12843 14 time time NN cord-010119-t1x9gknd 12843 15 point point NN cord-010119-t1x9gknd 12843 16 . . . cord-010119-t1x9gknd 12844 1 Inoculated inoculate VBN cord-010119-t1x9gknd 12844 2 BPA BPA NNP cord-010119-t1x9gknd 12844 3 and and CC cord-010119-t1x9gknd 12844 4 BPN BPN NNP cord-010119-t1x9gknd 12844 5 bottles bottle NNS cord-010119-t1x9gknd 12844 6 were be VBD cord-010119-t1x9gknd 12844 7 loaded load VBN cord-010119-t1x9gknd 12844 8 into into IN cord-010119-t1x9gknd 12844 9 the the DT cord-010119-t1x9gknd 12844 10 BacT BacT NNP cord-010119-t1x9gknd 12844 11 / / SYM cord-010119-t1x9gknd 12844 12 ALERT ALERT NNP cord-010119-t1x9gknd 12844 13 Microbial Microbial NNP cord-010119-t1x9gknd 12844 14 Detection Detection NNP cord-010119-t1x9gknd 12844 15 system system NN cord-010119-t1x9gknd 12844 16 at at IN cord-010119-t1x9gknd 12844 17 36 36 CD cord-010119-t1x9gknd 12844 18 C c NN cord-010119-t1x9gknd 12844 19 for for IN cord-010119-t1x9gknd 12844 20 automatic automatic JJ cord-010119-t1x9gknd 12844 21 monitoring monitoring NN cord-010119-t1x9gknd 12844 22 of of IN cord-010119-t1x9gknd 12844 23 growth growth NN cord-010119-t1x9gknd 12844 24 . . . cord-010119-t1x9gknd 12845 1 Negative negative JJ cord-010119-t1x9gknd 12845 2 BPA BPA NNP cord-010119-t1x9gknd 12845 3 and and CC cord-010119-t1x9gknd 12845 4 BPN BPN NNP cord-010119-t1x9gknd 12845 5 bottles bottle NNS cord-010119-t1x9gknd 12845 6 were be VBD cord-010119-t1x9gknd 12845 7 included include VBN cord-010119-t1x9gknd 12845 8 in in IN cord-010119-t1x9gknd 12845 9 duplicate duplicate NN cord-010119-t1x9gknd 12845 10 at at IN cord-010119-t1x9gknd 12845 11 each each DT cord-010119-t1x9gknd 12845 12 day day NN cord-010119-t1x9gknd 12845 13 of of IN cord-010119-t1x9gknd 12845 14 testing testing NN cord-010119-t1x9gknd 12845 15 . . . cord-010119-t1x9gknd 12846 1 Results result NNS cord-010119-t1x9gknd 12846 2 / / SYM cord-010119-t1x9gknd 12846 3 Finding finding NN cord-010119-t1x9gknd 12846 4 : : : cord-010119-t1x9gknd 12846 5 Escherichia escherichia NN cord-010119-t1x9gknd 12846 6 coli coli NNS cord-010119-t1x9gknd 12846 7 , , , cord-010119-t1x9gknd 12846 8 Staphylococcus Staphylococcus NNP cord-010119-t1x9gknd 12846 9 aureus aureus NN cord-010119-t1x9gknd 12846 10 , , , cord-010119-t1x9gknd 12846 11 Streptoococcus Streptoococcus NNP cord-010119-t1x9gknd 12846 12 pyogenes pyogene NNS cord-010119-t1x9gknd 12846 13 and and CC cord-010119-t1x9gknd 12846 14 Bacillus bacillus NN cord-010119-t1x9gknd 12846 15 subtilis subtili NNS cord-010119-t1x9gknd 12846 16 subsp subsp NN cord-010119-t1x9gknd 12846 17 . . . cord-010119-t1x9gknd 12847 1 spizizenii spizizenii NNP cord-010119-t1x9gknd 12847 2 were be VBD cord-010119-t1x9gknd 12847 3 positive positive JJ cord-010119-t1x9gknd 12847 4 in in IN cord-010119-t1x9gknd 12847 5 both both CC cord-010119-t1x9gknd 12847 6 the the DT cord-010119-t1x9gknd 12847 7 BPA BPA NNP cord-010119-t1x9gknd 12847 8 and and CC cord-010119-t1x9gknd 12847 9 BPN BPN NNP cord-010119-t1x9gknd 12847 10 culture culture NN cord-010119-t1x9gknd 12847 11 bottles bottle NNS cord-010119-t1x9gknd 12847 12 . . . cord-010119-t1x9gknd 12848 1 The the DT cord-010119-t1x9gknd 12848 2 aerobic aerobic JJ cord-010119-t1x9gknd 12848 3 Aspergillus aspergillus NN cord-010119-t1x9gknd 12848 4 brasiliensis brasiliensis NN cord-010119-t1x9gknd 12848 5 , , , cord-010119-t1x9gknd 12848 6 Candida Candida NNP cord-010119-t1x9gknd 12848 7 albicans albican NNS cord-010119-t1x9gknd 12848 8 , , , cord-010119-t1x9gknd 12848 9 and and CC cord-010119-t1x9gknd 12848 10 Pseudomonas Pseudomonas NNP cord-010119-t1x9gknd 12848 11 aeruginosa aeruginosa NN cord-010119-t1x9gknd 12848 12 grew grow VBD cord-010119-t1x9gknd 12848 13 and and CC cord-010119-t1x9gknd 12848 14 were be VBD cord-010119-t1x9gknd 12848 15 reported report VBN cord-010119-t1x9gknd 12848 16 positive positive JJ cord-010119-t1x9gknd 12848 17 in in IN cord-010119-t1x9gknd 12848 18 only only RB cord-010119-t1x9gknd 12848 19 the the DT cord-010119-t1x9gknd 12848 20 BPA BPA NNP cord-010119-t1x9gknd 12848 21 aerobic aerobic JJ cord-010119-t1x9gknd 12848 22 culture culture NN cord-010119-t1x9gknd 12848 23 bottle bottle NN cord-010119-t1x9gknd 12848 24 as as IN cord-010119-t1x9gknd 12848 25 expected expect VBN cord-010119-t1x9gknd 12848 26 . . . cord-010119-t1x9gknd 12849 1 While while IN cord-010119-t1x9gknd 12849 2 the the DT cord-010119-t1x9gknd 12849 3 obligate obligate JJ cord-010119-t1x9gknd 12849 4 anaerobe anaerobe NN cord-010119-t1x9gknd 12849 5 , , , cord-010119-t1x9gknd 12849 6 Clostridium Clostridium NNP cord-010119-t1x9gknd 12849 7 sporogenes sporogene NNS cord-010119-t1x9gknd 12849 8 was be VBD cord-010119-t1x9gknd 12849 9 positive positive JJ cord-010119-t1x9gknd 12849 10 only only RB cord-010119-t1x9gknd 12849 11 in in IN cord-010119-t1x9gknd 12849 12 the the DT cord-010119-t1x9gknd 12849 13 anaerobic anaerobic JJ cord-010119-t1x9gknd 12849 14 BPN BPN NNP cord-010119-t1x9gknd 12849 15 culture culture NN cord-010119-t1x9gknd 12849 16 bottles bottle NNS cord-010119-t1x9gknd 12849 17 . . . cord-010119-t1x9gknd 12850 1 Bacterial bacterial JJ cord-010119-t1x9gknd 12850 2 cultures culture NNS cord-010119-t1x9gknd 12850 3 were be VBD cord-010119-t1x9gknd 12850 4 positive positive JJ cord-010119-t1x9gknd 12850 5 in in IN cord-010119-t1x9gknd 12850 6 the the DT cord-010119-t1x9gknd 12850 7 BacT BacT NNP cord-010119-t1x9gknd 12850 8 / / SYM cord-010119-t1x9gknd 12850 9 ALERT ALERT NNP cord-010119-t1x9gknd 12850 10 BPA BPA NNP cord-010119-t1x9gknd 12850 11 and and CC cord-010119-t1x9gknd 12850 12 BPN BPN NNP cord-010119-t1x9gknd 12850 13 bottles bottle NNS cord-010119-t1x9gknd 12850 14 < < XX cord-010119-t1x9gknd 12850 15 1 1 CD cord-010119-t1x9gknd 12850 16 days day NNS cord-010119-t1x9gknd 12850 17 and and CC cord-010119-t1x9gknd 12850 18 the the DT cord-010119-t1x9gknd 12850 19 fungal fungal JJ cord-010119-t1x9gknd 12850 20 organisms organism NNS cord-010119-t1x9gknd 12850 21 in in IN cord-010119-t1x9gknd 12850 22 < < NNP cord-010119-t1x9gknd 12850 23 2 2 CD cord-010119-t1x9gknd 12850 24 days day NNS cord-010119-t1x9gknd 12850 25 . . . cord-010119-t1x9gknd 12851 1 The the DT cord-010119-t1x9gknd 12851 2 overall overall JJ cord-010119-t1x9gknd 12851 3 agreement agreement NN cord-010119-t1x9gknd 12851 4 was be VBD cord-010119-t1x9gknd 12851 5 99.8 99.8 CD cord-010119-t1x9gknd 12851 6 % % NN cord-010119-t1x9gknd 12851 7 in in IN cord-010119-t1x9gknd 12851 8 698 698 CD cord-010119-t1x9gknd 12851 9 bottles bottle NNS cord-010119-t1x9gknd 12851 10 tested test VBN cord-010119-t1x9gknd 12851 11 here here RB cord-010119-t1x9gknd 12851 12 . . . cord-010119-t1x9gknd 12852 1 No no DT cord-010119-t1x9gknd 12852 2 significant significant JJ cord-010119-t1x9gknd 12852 3 differences difference NNS cord-010119-t1x9gknd 12852 4 were be VBD cord-010119-t1x9gknd 12852 5 observed observe VBN cord-010119-t1x9gknd 12852 6 in in IN cord-010119-t1x9gknd 12852 7 the the DT cord-010119-t1x9gknd 12852 8 time time NN cord-010119-t1x9gknd 12852 9 to to IN cord-010119-t1x9gknd 12852 10 detection detection NN cord-010119-t1x9gknd 12852 11 between between IN cord-010119-t1x9gknd 12852 12 the the DT cord-010119-t1x9gknd 12852 13 different different JJ cord-010119-t1x9gknd 12852 14 lots lot NNS cord-010119-t1x9gknd 12852 15 or or CC cord-010119-t1x9gknd 12852 16 between between IN cord-010119-t1x9gknd 12852 17 the the DT cord-010119-t1x9gknd 12852 18 different different JJ cord-010119-t1x9gknd 12852 19 analyst analyst NN cord-010119-t1x9gknd 12852 20 . . . cord-010119-t1x9gknd 12853 1 Conclusion conclusion NN cord-010119-t1x9gknd 12853 2 : : : cord-010119-t1x9gknd 12854 1 The the DT cord-010119-t1x9gknd 12854 2 BioBall BioBall NNP cord-010119-t1x9gknd 12854 3 prepared prepared JJ cord-010119-t1x9gknd 12854 4 organisms organism NNS cord-010119-t1x9gknd 12854 5 demonstrated demonstrate VBD cord-010119-t1x9gknd 12854 6 a a DT cord-010119-t1x9gknd 12854 7 reproducible reproducible JJ cord-010119-t1x9gknd 12854 8 method method NN cord-010119-t1x9gknd 12854 9 as as IN cord-010119-t1x9gknd 12854 10 both both CC cord-010119-t1x9gknd 12854 11 a a DT cord-010119-t1x9gknd 12854 12 comprehensive comprehensive JJ cord-010119-t1x9gknd 12854 13 and and CC cord-010119-t1x9gknd 12854 14 streamline streamline VB cord-010119-t1x9gknd 12854 15 approach approach NN cord-010119-t1x9gknd 12854 16 for for IN cord-010119-t1x9gknd 12854 17 the the DT cord-010119-t1x9gknd 12854 18 quality quality NN cord-010119-t1x9gknd 12854 19 control control NN cord-010119-t1x9gknd 12854 20 of of IN cord-010119-t1x9gknd 12854 21 BacT BacT NNP cord-010119-t1x9gknd 12854 22 / / SYM cord-010119-t1x9gknd 12854 23 ALERT ALERT NNP cord-010119-t1x9gknd 12854 24 BPA BPA NNP cord-010119-t1x9gknd 12854 25 and and CC cord-010119-t1x9gknd 12854 26 BPN BPN NNP cord-010119-t1x9gknd 12854 27 culture culture NN cord-010119-t1x9gknd 12854 28 media medium NNS cord-010119-t1x9gknd 12854 29 . . . cord-010119-t1x9gknd 12855 1 The the DT cord-010119-t1x9gknd 12855 2 method method NN cord-010119-t1x9gknd 12855 3 was be VBD cord-010119-t1x9gknd 12855 4 simple simple JJ cord-010119-t1x9gknd 12855 5 and and CC cord-010119-t1x9gknd 12855 6 did do VBD cord-010119-t1x9gknd 12855 7 not not RB cord-010119-t1x9gknd 12855 8 require require VB cord-010119-t1x9gknd 12855 9 additional additional JJ cord-010119-t1x9gknd 12855 10 microbial microbial JJ cord-010119-t1x9gknd 12855 11 preparations preparation NNS cord-010119-t1x9gknd 12855 12 or or CC cord-010119-t1x9gknd 12855 13 storage storage NN cord-010119-t1x9gknd 12855 14 of of IN cord-010119-t1x9gknd 12855 15 live live JJ cord-010119-t1x9gknd 12855 16 organisms organism NNS cord-010119-t1x9gknd 12855 17 by by IN cord-010119-t1x9gknd 12855 18 the the DT cord-010119-t1x9gknd 12855 19 laboratory laboratory NN cord-010119-t1x9gknd 12855 20 . . . cord-010119-t1x9gknd 12856 1 Use use NN cord-010119-t1x9gknd 12856 2 of of IN cord-010119-t1x9gknd 12856 3 an an DT cord-010119-t1x9gknd 12856 4 Electronic Electronic NNP cord-010119-t1x9gknd 12856 5 Patient Patient NNP cord-010119-t1x9gknd 12856 6 Identification Identification NNP cord-010119-t1x9gknd 12856 7 System System NNP cord-010119-t1x9gknd 12856 8 for for IN cord-010119-t1x9gknd 12856 9 Blood Blood NNP cord-010119-t1x9gknd 12856 10 Banking Banking NNP cord-010119-t1x9gknd 12856 11 Specimen Specimen NNP cord-010119-t1x9gknd 12856 12 Labeling labeling NN cord-010119-t1x9gknd 12856 13 Found find VBN cord-010119-t1x9gknd 12856 14 to to TO cord-010119-t1x9gknd 12856 15 be be VB cord-010119-t1x9gknd 12856 16 Superior Superior NNP cord-010119-t1x9gknd 12856 17 over over IN cord-010119-t1x9gknd 12856 18 Historical Historical NNP cord-010119-t1x9gknd 12856 19 Armband armband NN cord-010119-t1x9gknd 12856 20 Approaches Approaches NNPS cord-010119-t1x9gknd 12857 1 Annie Annie NNP cord-010119-t1x9gknd 12857 2 Newton Newton NNP cord-010119-t1x9gknd 12857 3 * * NFP cord-010119-t1x9gknd 12857 4 1 1 CD cord-010119-t1x9gknd 12857 5 , , , cord-010119-t1x9gknd 12857 6 Diane Diane NNP cord-010119-t1x9gknd 12857 7 Schafer Schafer NNP cord-010119-t1x9gknd 12857 8 2 2 CD cord-010119-t1x9gknd 12857 9 , , , cord-010119-t1x9gknd 12857 10 Debra Debra NNP cord-010119-t1x9gknd 12857 11 Brown Brown NNP cord-010119-t1x9gknd 12857 12 1 1 CD cord-010119-t1x9gknd 12857 13 , , , cord-010119-t1x9gknd 12857 14 Jesse Jesse NNP cord-010119-t1x9gknd 12857 15 Cox Cox NNP cord-010119-t1x9gknd 12857 16 3 3 CD cord-010119-t1x9gknd 12857 17 , , , cord-010119-t1x9gknd 12857 18 Scott Scott NNP cord-010119-t1x9gknd 12857 19 Koepsell Koepsell NNP cord-010119-t1x9gknd 12857 20 3 3 CD cord-010119-t1x9gknd 12857 21 and and CC cord-010119-t1x9gknd 12857 22 Sara Sara NNP cord-010119-t1x9gknd 12857 23 Shunkwiler Shunkwiler NNP cord-010119-t1x9gknd 12858 1 3 3 LS cord-010119-t1x9gknd 12858 2 . . . cord-010119-t1x9gknd 12858 3 1 1 CD cord-010119-t1x9gknd 12858 4 Nebraska Nebraska NNP cord-010119-t1x9gknd 12858 5 Medicine Medicine NNP cord-010119-t1x9gknd 12858 6 , , , cord-010119-t1x9gknd 12858 7 2 2 CD cord-010119-t1x9gknd 12858 8 The the DT cord-010119-t1x9gknd 12858 9 Nebraska Nebraska NNP cord-010119-t1x9gknd 12858 10 Medical Medical NNP cord-010119-t1x9gknd 12858 11 Center Center NNP cord-010119-t1x9gknd 12858 12 , , , cord-010119-t1x9gknd 12858 13 3 3 CD cord-010119-t1x9gknd 12858 14 University University NNP cord-010119-t1x9gknd 12858 15 of of IN cord-010119-t1x9gknd 12858 16 Nebraska Nebraska NNP cord-010119-t1x9gknd 12858 17 Medical Medical NNP cord-010119-t1x9gknd 12858 18 Center Center NNP cord-010119-t1x9gknd 12858 19 Background Background NNP cord-010119-t1x9gknd 12858 20 / / SYM cord-010119-t1x9gknd 12858 21 Case Case NNP cord-010119-t1x9gknd 12858 22 Studies Studies NNPS cord-010119-t1x9gknd 12858 23 : : : cord-010119-t1x9gknd 12858 24 Anticipating anticipate VBG cord-010119-t1x9gknd 12858 25 the the DT cord-010119-t1x9gknd 12858 26 implementation implementation NN cord-010119-t1x9gknd 12858 27 of of IN cord-010119-t1x9gknd 12858 28 the the DT cord-010119-t1x9gknd 12858 29 new new JJ cord-010119-t1x9gknd 12858 30 ( ( -LRB- cord-010119-t1x9gknd 12858 31 30 30 CD cord-010119-t1x9gknd 12858 32 th th XX cord-010119-t1x9gknd 12858 33 addition addition NN cord-010119-t1x9gknd 12858 34 ) ) -RRB- cord-010119-t1x9gknd 12859 1 AABB AABB NNP cord-010119-t1x9gknd 12859 2 standard standard NN cord-010119-t1x9gknd 12859 3 concerning concern VBG cord-010119-t1x9gknd 12859 4 the the DT cord-010119-t1x9gknd 12859 5 confirmation confirmation NN cord-010119-t1x9gknd 12859 6 of of IN cord-010119-t1x9gknd 12859 7 patient patient NN cord-010119-t1x9gknd 12859 8 ABO ABO NNP cord-010119-t1x9gknd 12859 9 blood blood NN cord-010119-t1x9gknd 12859 10 typing typing NN cord-010119-t1x9gknd 12859 11 of of IN cord-010119-t1x9gknd 12859 12 Type type NN cord-010119-t1x9gknd 12859 13 and and CC cord-010119-t1x9gknd 12859 14 Screen Screen NNP cord-010119-t1x9gknd 12859 15 ( ( -LRB- cord-010119-t1x9gknd 12859 16 crossmatch crossmatch NN cord-010119-t1x9gknd 12859 17 ) ) -RRB- cord-010119-t1x9gknd 12859 18 specimens specimen NNS cord-010119-t1x9gknd 12859 19 performed perform VBN cord-010119-t1x9gknd 12859 20 prior prior RB cord-010119-t1x9gknd 12859 21 to to IN cord-010119-t1x9gknd 12859 22 the the DT cord-010119-t1x9gknd 12859 23 issue issue NN cord-010119-t1x9gknd 12859 24 of of IN cord-010119-t1x9gknd 12859 25 crossmatched crossmatched JJ cord-010119-t1x9gknd 12859 26 blood blood NN cord-010119-t1x9gknd 12859 27 products product NNS cord-010119-t1x9gknd 12859 28 , , , cord-010119-t1x9gknd 12859 29 laboratory laboratory NN cord-010119-t1x9gknd 12859 30 and and CC cord-010119-t1x9gknd 12859 31 organizational organizational JJ cord-010119-t1x9gknd 12859 32 leadership leadership NN cord-010119-t1x9gknd 12859 33 evaluated evaluate VBD cord-010119-t1x9gknd 12859 34 the the DT cord-010119-t1x9gknd 12859 35 practical practical JJ cord-010119-t1x9gknd 12859 36 application application NN cord-010119-t1x9gknd 12859 37 of of IN cord-010119-t1x9gknd 12859 38 an an DT cord-010119-t1x9gknd 12859 39 electronic electronic JJ cord-010119-t1x9gknd 12859 40 patient patient NN cord-010119-t1x9gknd 12859 41 identification identification NN cord-010119-t1x9gknd 12859 42 system system NN cord-010119-t1x9gknd 12859 43 to to TO cord-010119-t1x9gknd 12859 44 label label VB cord-010119-t1x9gknd 12859 45 blood blood NN cord-010119-t1x9gknd 12859 46 bank bank NN cord-010119-t1x9gknd 12859 47 specimen specimen NN cord-010119-t1x9gknd 12859 48 collections collection NNS cord-010119-t1x9gknd 12859 49 versus versus IN cord-010119-t1x9gknd 12859 50 the the DT cord-010119-t1x9gknd 12859 51 traditional traditional JJ cord-010119-t1x9gknd 12859 52 use use NN cord-010119-t1x9gknd 12859 53 of of IN cord-010119-t1x9gknd 12859 54 blood blood NN cord-010119-t1x9gknd 12859 55 bank bank NN cord-010119-t1x9gknd 12859 56 armbands armband NNS cord-010119-t1x9gknd 12859 57 . . . cord-010119-t1x9gknd 12860 1 Continued continue VBN cord-010119-t1x9gknd 12860 2 use use NN cord-010119-t1x9gknd 12860 3 of of IN cord-010119-t1x9gknd 12860 4 the the DT cord-010119-t1x9gknd 12860 5 armbands armband NNS cord-010119-t1x9gknd 12860 6 would would MD cord-010119-t1x9gknd 12860 7 require require VB cord-010119-t1x9gknd 12860 8 a a DT cord-010119-t1x9gknd 12860 9 second second JJ cord-010119-t1x9gknd 12860 10 sample sample NN cord-010119-t1x9gknd 12860 11 for for IN cord-010119-t1x9gknd 12860 12 ABO ABO NNP cord-010119-t1x9gknd 12860 13 confirmation confirmation NN cord-010119-t1x9gknd 12860 14 of of IN cord-010119-t1x9gknd 12860 15 patients patient NNS cord-010119-t1x9gknd 12860 16 that that WDT cord-010119-t1x9gknd 12860 17 did do VBD cord-010119-t1x9gknd 12860 18 not not RB cord-010119-t1x9gknd 12860 19 have have VB cord-010119-t1x9gknd 12860 20 a a DT cord-010119-t1x9gknd 12860 21 historical historical JJ cord-010119-t1x9gknd 12860 22 blood blood NN cord-010119-t1x9gknd 12860 23 type type NN cord-010119-t1x9gknd 12860 24 on on IN cord-010119-t1x9gknd 12860 25 file file NN cord-010119-t1x9gknd 12860 26 . . . cord-010119-t1x9gknd 12861 1 Concern concern NN cord-010119-t1x9gknd 12861 2 was be VBD cord-010119-t1x9gknd 12861 3 raised raise VBN cord-010119-t1x9gknd 12861 4 regarding regard VBG cord-010119-t1x9gknd 12861 5 the the DT cord-010119-t1x9gknd 12861 6 amount amount NN cord-010119-t1x9gknd 12861 7 of of IN cord-010119-t1x9gknd 12861 8 increased increase VBN cord-010119-t1x9gknd 12861 9 workload workload NN cord-010119-t1x9gknd 12861 10 of of IN cord-010119-t1x9gknd 12861 11 staff staff NN cord-010119-t1x9gknd 12861 12 and and CC cord-010119-t1x9gknd 12861 13 delayed delay VBN cord-010119-t1x9gknd 12861 14 results result NNS cord-010119-t1x9gknd 12861 15 availability availability NN cord-010119-t1x9gknd 12861 16 based base VBN cord-010119-t1x9gknd 12861 17 on on IN cord-010119-t1x9gknd 12861 18 the the DT cord-010119-t1x9gknd 12861 19 number number NN cord-010119-t1x9gknd 12861 20 of of IN cord-010119-t1x9gknd 12861 21 increased increase VBN cord-010119-t1x9gknd 12861 22 specimens specimen NNS cord-010119-t1x9gknd 12861 23 that that WDT cord-010119-t1x9gknd 12861 24 would would MD cord-010119-t1x9gknd 12861 25 be be VB cord-010119-t1x9gknd 12861 26 generated generate VBN cord-010119-t1x9gknd 12861 27 , , , cord-010119-t1x9gknd 12861 28 as as RB cord-010119-t1x9gknd 12861 29 well well RB cord-010119-t1x9gknd 12861 30 the the DT cord-010119-t1x9gknd 12861 31 potential potential NN cord-010119-t1x9gknd 12861 32 for for IN cord-010119-t1x9gknd 12861 33 increased increase VBN cord-010119-t1x9gknd 12861 34 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 12861 35 blood blood NN cord-010119-t1x9gknd 12861 36 loss loss NN cord-010119-t1x9gknd 12861 37 and and CC cord-010119-t1x9gknd 12861 38 patient patient JJ cord-010119-t1x9gknd 12861 39 dissatisfaction dissatisfaction NN cord-010119-t1x9gknd 12861 40 . . . cord-010119-t1x9gknd 12862 1 Moreover moreover RB cord-010119-t1x9gknd 12862 2 , , , cord-010119-t1x9gknd 12862 3 2 2 CD cord-010119-t1x9gknd 12862 4 nd nd NNP cord-010119-t1x9gknd 12862 5 sample sample NN cord-010119-t1x9gknd 12862 6 collection collection NN cord-010119-t1x9gknd 12862 7 alone alone RB cord-010119-t1x9gknd 12862 8 would would MD cord-010119-t1x9gknd 12862 9 not not RB cord-010119-t1x9gknd 12862 10 improve improve VB cord-010119-t1x9gknd 12862 11 the the DT cord-010119-t1x9gknd 12862 12 rate rate NN cord-010119-t1x9gknd 12862 13 of of IN cord-010119-t1x9gknd 12862 14 mislabeled mislabele VBN cord-010119-t1x9gknd 12862 15 specimens specimen NNS cord-010119-t1x9gknd 12862 16 observed observe VBN cord-010119-t1x9gknd 12862 17 , , , cord-010119-t1x9gknd 12862 18 which which WDT cord-010119-t1x9gknd 12862 19 is be VBZ cord-010119-t1x9gknd 12862 20 of of IN cord-010119-t1x9gknd 12862 21 supplementary supplementary JJ cord-010119-t1x9gknd 12862 22 concern concern NN cord-010119-t1x9gknd 12862 23 . . . cord-010119-t1x9gknd 12863 1 Study Study NNP cord-010119-t1x9gknd 12863 2 Design Design NNP cord-010119-t1x9gknd 12863 3 / / SYM cord-010119-t1x9gknd 12863 4 Method method NN cord-010119-t1x9gknd 12863 5 : : : cord-010119-t1x9gknd 12863 6 Current current JJ cord-010119-t1x9gknd 12863 7 organization organization NN cord-010119-t1x9gknd 12863 8 employment employment NN cord-010119-t1x9gknd 12863 9 of of IN cord-010119-t1x9gknd 12863 10 an an DT cord-010119-t1x9gknd 12863 11 electronic electronic JJ cord-010119-t1x9gknd 12863 12 patient patient NN cord-010119-t1x9gknd 12863 13 identification identification NN cord-010119-t1x9gknd 12863 14 system system NN cord-010119-t1x9gknd 12863 15 for for IN cord-010119-t1x9gknd 12863 16 the the DT cord-010119-t1x9gknd 12863 17 labeling labeling NN cord-010119-t1x9gknd 12863 18 of of IN cord-010119-t1x9gknd 12863 19 other other JJ cord-010119-t1x9gknd 12863 20 laboratory laboratory NN cord-010119-t1x9gknd 12863 21 specimen specimen NN cord-010119-t1x9gknd 12863 22 collections collection NNS cord-010119-t1x9gknd 12863 23 made make VBD cord-010119-t1x9gknd 12863 24 it -PRON- PRP cord-010119-t1x9gknd 12863 25 feasible feasible JJ cord-010119-t1x9gknd 12863 26 for for IN cord-010119-t1x9gknd 12863 27 applying apply VBG cord-010119-t1x9gknd 12863 28 this this DT cord-010119-t1x9gknd 12863 29 technology technology NN cord-010119-t1x9gknd 12863 30 to to IN cord-010119-t1x9gknd 12863 31 the the DT cord-010119-t1x9gknd 12863 32 blood blood NN cord-010119-t1x9gknd 12863 33 bank bank NN cord-010119-t1x9gknd 12863 34 as as RB cord-010119-t1x9gknd 12863 35 well well RB cord-010119-t1x9gknd 12863 36 . . . cord-010119-t1x9gknd 12864 1 An an DT cord-010119-t1x9gknd 12864 2 in in IN cord-010119-t1x9gknd 12864 3 - - HYPH cord-010119-t1x9gknd 12864 4 depth depth NN cord-010119-t1x9gknd 12864 5 evaluation evaluation NN cord-010119-t1x9gknd 12864 6 , , , cord-010119-t1x9gknd 12864 7 including include VBG cord-010119-t1x9gknd 12864 8 a a DT cord-010119-t1x9gknd 12864 9 failure failure NN cord-010119-t1x9gknd 12864 10 modes mode NNS cord-010119-t1x9gknd 12864 11 and and CC cord-010119-t1x9gknd 12864 12 effects effect NNS cord-010119-t1x9gknd 12864 13 analysis analysis NN cord-010119-t1x9gknd 12864 14 ( ( -LRB- cord-010119-t1x9gknd 12864 15 FMEA FMEA NNP cord-010119-t1x9gknd 12864 16 ) ) -RRB- cord-010119-t1x9gknd 12864 17 spanning span VBG cord-010119-t1x9gknd 12864 18 several several JJ cord-010119-t1x9gknd 12864 19 days day NNS cord-010119-t1x9gknd 12864 20 , , , cord-010119-t1x9gknd 12864 21 was be VBD cord-010119-t1x9gknd 12864 22 completed complete VBN cord-010119-t1x9gknd 12864 23 to to TO cord-010119-t1x9gknd 12864 24 ensure ensure VB cord-010119-t1x9gknd 12864 25 that that IN cord-010119-t1x9gknd 12864 26 the the DT cord-010119-t1x9gknd 12864 27 use use NN cord-010119-t1x9gknd 12864 28 of of IN cord-010119-t1x9gknd 12864 29 the the DT cord-010119-t1x9gknd 12864 30 electronic electronic JJ cord-010119-t1x9gknd 12864 31 system system NN cord-010119-t1x9gknd 12864 32 would would MD cord-010119-t1x9gknd 12864 33 produce produce VB cord-010119-t1x9gknd 12864 34 comparable comparable JJ cord-010119-t1x9gknd 12864 35 or or CC cord-010119-t1x9gknd 12864 36 superior superior JJ cord-010119-t1x9gknd 12864 37 safety safety NN cord-010119-t1x9gknd 12864 38 results result NNS cord-010119-t1x9gknd 12864 39 to to IN cord-010119-t1x9gknd 12864 40 its -PRON- PRP$ cord-010119-t1x9gknd 12864 41 armband armband NN cord-010119-t1x9gknd 12864 42 counterpart counterpart NN cord-010119-t1x9gknd 12864 43 . . . cord-010119-t1x9gknd 12865 1 An an DT cord-010119-t1x9gknd 12865 2 alternate alternate JJ cord-010119-t1x9gknd 12865 3 process process NN cord-010119-t1x9gknd 12865 4 for for IN cord-010119-t1x9gknd 12865 5 specimen specimen JJ cord-010119-t1x9gknd 12865 6 labeling labeling NN cord-010119-t1x9gknd 12865 7 and and CC cord-010119-t1x9gknd 12865 8 ABO ABO NNP cord-010119-t1x9gknd 12865 9 confirmation confirmation NN cord-010119-t1x9gknd 12865 10 ( ( -LRB- cord-010119-t1x9gknd 12865 11 which which WDT cord-010119-t1x9gknd 12865 12 would would MD cord-010119-t1x9gknd 12865 13 satisfy satisfy VB cord-010119-t1x9gknd 12865 14 the the DT cord-010119-t1x9gknd 12865 15 new new JJ cord-010119-t1x9gknd 12865 16 standard standard NN cord-010119-t1x9gknd 12865 17 ) ) -RRB- cord-010119-t1x9gknd 12865 18 was be VBD cord-010119-t1x9gknd 12865 19 established establish VBN cord-010119-t1x9gknd 12865 20 to to TO cord-010119-t1x9gknd 12865 21 support support VB cord-010119-t1x9gknd 12865 22 care care NN cord-010119-t1x9gknd 12865 23 areas area NNS cord-010119-t1x9gknd 12865 24 that that WDT cord-010119-t1x9gknd 12865 25 did do VBD cord-010119-t1x9gknd 12865 26 not not RB cord-010119-t1x9gknd 12865 27 have have VB cord-010119-t1x9gknd 12865 28 the the DT cord-010119-t1x9gknd 12865 29 capability capability NN cord-010119-t1x9gknd 12865 30 of of IN cord-010119-t1x9gknd 12865 31 using use VBG cord-010119-t1x9gknd 12865 32 the the DT cord-010119-t1x9gknd 12865 33 electronic electronic JJ cord-010119-t1x9gknd 12865 34 system system NN cord-010119-t1x9gknd 12865 35 . . . cord-010119-t1x9gknd 12866 1 Extensive extensive JJ cord-010119-t1x9gknd 12866 2 education education NN cord-010119-t1x9gknd 12866 3 was be VBD cord-010119-t1x9gknd 12866 4 provided provide VBN cord-010119-t1x9gknd 12866 5 to to IN cord-010119-t1x9gknd 12866 6 all all DT cord-010119-t1x9gknd 12866 7 staff staff NN cord-010119-t1x9gknd 12866 8 ( ( -LRB- cord-010119-t1x9gknd 12866 9 physicians physician NNS cord-010119-t1x9gknd 12866 10 , , , cord-010119-t1x9gknd 12866 11 advanced advanced JJ cord-010119-t1x9gknd 12866 12 practice practice NN cord-010119-t1x9gknd 12866 13 providers provider NNS cord-010119-t1x9gknd 12866 14 , , , cord-010119-t1x9gknd 12866 15 phlebotomist phlebotomist NN cord-010119-t1x9gknd 12866 16 and and CC cord-010119-t1x9gknd 12866 17 nurses nurse NNS cord-010119-t1x9gknd 12866 18 ) ) -RRB- cord-010119-t1x9gknd 12866 19 to to TO cord-010119-t1x9gknd 12866 20 ensure ensure VB cord-010119-t1x9gknd 12866 21 comprehension comprehension NN cord-010119-t1x9gknd 12866 22 as as RB cord-010119-t1x9gknd 12866 23 well well RB cord-010119-t1x9gknd 12866 24 rational rational JJ cord-010119-t1x9gknd 12866 25 for for IN cord-010119-t1x9gknd 12866 26 the the DT cord-010119-t1x9gknd 12866 27 new new JJ cord-010119-t1x9gknd 12866 28 process process NN cord-010119-t1x9gknd 12866 29 . . . cord-010119-t1x9gknd 12867 1 Alerts alert NNS cord-010119-t1x9gknd 12867 2 were be VBD cord-010119-t1x9gknd 12867 3 congruently congruently RB cord-010119-t1x9gknd 12867 4 built build VBN cord-010119-t1x9gknd 12867 5 into into IN cord-010119-t1x9gknd 12867 6 the the DT cord-010119-t1x9gknd 12867 7 electronic electronic JJ cord-010119-t1x9gknd 12867 8 health health NN cord-010119-t1x9gknd 12867 9 record record NN cord-010119-t1x9gknd 12867 10 ( ( -LRB- cord-010119-t1x9gknd 12867 11 EHR EHR NNP cord-010119-t1x9gknd 12867 12 ) ) -RRB- cord-010119-t1x9gknd 12867 13 to to TO cord-010119-t1x9gknd 12867 14 supplement supplement VB cord-010119-t1x9gknd 12867 15 any any DT cord-010119-t1x9gknd 12867 16 information information NN cord-010119-t1x9gknd 12867 17 regarding regard VBG cord-010119-t1x9gknd 12867 18 crossmatch crossmatch NN cord-010119-t1x9gknd 12867 19 testing testing NN cord-010119-t1x9gknd 12867 20 expiration expiration NN cord-010119-t1x9gknd 12867 21 that that WDT cord-010119-t1x9gknd 12867 22 may may MD cord-010119-t1x9gknd 12867 23 not not RB cord-010119-t1x9gknd 12867 24 be be VB cord-010119-t1x9gknd 12867 25 readily readily RB cord-010119-t1x9gknd 12867 26 available available JJ cord-010119-t1x9gknd 12867 27 by by IN cord-010119-t1x9gknd 12867 28 the the DT cord-010119-t1x9gknd 12867 29 elimination elimination NN cord-010119-t1x9gknd 12867 30 of of IN cord-010119-t1x9gknd 12867 31 the the DT cord-010119-t1x9gknd 12867 32 armband armband NN cord-010119-t1x9gknd 12867 33 use use NN cord-010119-t1x9gknd 12867 34 . . . cord-010119-t1x9gknd 12868 1 Results result NNS cord-010119-t1x9gknd 12868 2 / / SYM cord-010119-t1x9gknd 12868 3 Finding finding NN cord-010119-t1x9gknd 12868 4 : : : cord-010119-t1x9gknd 12869 1 Within within IN cord-010119-t1x9gknd 12869 2 days day NNS cord-010119-t1x9gknd 12869 3 of of IN cord-010119-t1x9gknd 12869 4 implementing implement VBG cord-010119-t1x9gknd 12869 5 the the DT cord-010119-t1x9gknd 12869 6 new new JJ cord-010119-t1x9gknd 12869 7 process process NN cord-010119-t1x9gknd 12869 8 ( ( -LRB- cord-010119-t1x9gknd 12869 9 September September NNP cord-010119-t1x9gknd 12869 10 11 11 CD cord-010119-t1x9gknd 12869 11 , , , cord-010119-t1x9gknd 12869 12 2016 2016 CD cord-010119-t1x9gknd 12869 13 ) ) -RRB- cord-010119-t1x9gknd 12869 14 , , , cord-010119-t1x9gknd 12869 15 there there EX cord-010119-t1x9gknd 12869 16 was be VBD cord-010119-t1x9gknd 12869 17 a a DT cord-010119-t1x9gknd 12869 18 noticeable noticeable JJ cord-010119-t1x9gknd 12869 19 reduction reduction NN cord-010119-t1x9gknd 12869 20 in in IN cord-010119-t1x9gknd 12869 21 the the DT cord-010119-t1x9gknd 12869 22 amount amount NN cord-010119-t1x9gknd 12869 23 of of IN cord-010119-t1x9gknd 12869 24 mislabeled mislabele VBN cord-010119-t1x9gknd 12869 25 blood blood NN cord-010119-t1x9gknd 12869 26 bank bank NN cord-010119-t1x9gknd 12869 27 specimens specimen NNS cord-010119-t1x9gknd 12869 28 received receive VBN cord-010119-t1x9gknd 12869 29 , , , cord-010119-t1x9gknd 12869 30 totaling total VBG cord-010119-t1x9gknd 12869 31 4 4 CD cord-010119-t1x9gknd 12869 32 in in IN cord-010119-t1x9gknd 12869 33 6 6 CD cord-010119-t1x9gknd 12869 34 months month NNS cord-010119-t1x9gknd 12869 35 post post NN cord-010119-t1x9gknd 12869 36 implementation implementation NN cord-010119-t1x9gknd 12869 37 compared compare VBN cord-010119-t1x9gknd 12869 38 to to IN cord-010119-t1x9gknd 12869 39 144 144 CD cord-010119-t1x9gknd 12869 40 in in IN cord-010119-t1x9gknd 12869 41 the the DT cord-010119-t1x9gknd 12869 42 6 6 CD cord-010119-t1x9gknd 12869 43 months month NNS cord-010119-t1x9gknd 12869 44 prior prior RB cord-010119-t1x9gknd 12869 45 . . . cord-010119-t1x9gknd 12870 1 In in IN cord-010119-t1x9gknd 12870 2 addition addition NN cord-010119-t1x9gknd 12870 3 , , , cord-010119-t1x9gknd 12870 4 the the DT cord-010119-t1x9gknd 12870 5 vast vast JJ cord-010119-t1x9gknd 12870 6 majority majority NN cord-010119-t1x9gknd 12870 7 of of IN cord-010119-t1x9gknd 12870 8 specimens specimen NNS cord-010119-t1x9gknd 12870 9 received receive VBN cord-010119-t1x9gknd 12870 10 into into IN cord-010119-t1x9gknd 12870 11 the the DT cord-010119-t1x9gknd 12870 12 blood blood NN cord-010119-t1x9gknd 12870 13 bank bank NN cord-010119-t1x9gknd 12870 14 are be VBP cord-010119-t1x9gknd 12870 15 henceforth henceforth RB cord-010119-t1x9gknd 12870 16 collected collect VBN cord-010119-t1x9gknd 12870 17 and and CC cord-010119-t1x9gknd 12870 18 labeled label VBN cord-010119-t1x9gknd 12870 19 using use VBG cord-010119-t1x9gknd 12870 20 the the DT cord-010119-t1x9gknd 12870 21 electronic electronic JJ cord-010119-t1x9gknd 12870 22 system system NN cord-010119-t1x9gknd 12870 23 and and CC cord-010119-t1x9gknd 12870 24 thus thus RB cord-010119-t1x9gknd 12870 25 have have VBP cord-010119-t1x9gknd 12870 26 reduced reduce VBN cord-010119-t1x9gknd 12870 27 the the DT cord-010119-t1x9gknd 12870 28 amount amount NN cord-010119-t1x9gknd 12870 29 of of IN cord-010119-t1x9gknd 12870 30 potential potential JJ cord-010119-t1x9gknd 12870 31 2 2 CD cord-010119-t1x9gknd 12870 32 nd nd NNP cord-010119-t1x9gknd 12870 33 specimen specimen NN cord-010119-t1x9gknd 12870 34 collections collection NNS cord-010119-t1x9gknd 12870 35 needed need VBN cord-010119-t1x9gknd 12870 36 for for IN cord-010119-t1x9gknd 12870 37 ABO ABO NNP cord-010119-t1x9gknd 12870 38 confirmation confirmation NN cord-010119-t1x9gknd 12870 39 . . . cord-010119-t1x9gknd 12871 1 Conclusion conclusion NN cord-010119-t1x9gknd 12871 2 : : : cord-010119-t1x9gknd 12871 3 Use Use NNP cord-010119-t1x9gknd 12871 4 of of IN cord-010119-t1x9gknd 12871 5 an an DT cord-010119-t1x9gknd 12871 6 electronic electronic JJ cord-010119-t1x9gknd 12871 7 patient patient NN cord-010119-t1x9gknd 12871 8 identification identification NN cord-010119-t1x9gknd 12871 9 system system NN cord-010119-t1x9gknd 12871 10 for for IN cord-010119-t1x9gknd 12871 11 labeling label VBG cord-010119-t1x9gknd 12871 12 blood blood NN cord-010119-t1x9gknd 12871 13 bank bank NN cord-010119-t1x9gknd 12871 14 specimen specimen NN cord-010119-t1x9gknd 12871 15 collections collection NNS cord-010119-t1x9gknd 12871 16 in in IN cord-010119-t1x9gknd 12871 17 lieu lieu NN cord-010119-t1x9gknd 12871 18 of of IN cord-010119-t1x9gknd 12871 19 traditional traditional JJ cord-010119-t1x9gknd 12871 20 blood blood NN cord-010119-t1x9gknd 12871 21 bank bank NN cord-010119-t1x9gknd 12871 22 armbands armband NNS cord-010119-t1x9gknd 12871 23 has have VBZ cord-010119-t1x9gknd 12871 24 proven prove VBN cord-010119-t1x9gknd 12871 25 to to TO cord-010119-t1x9gknd 12871 26 improve improve VB cord-010119-t1x9gknd 12871 27 patient patient JJ cord-010119-t1x9gknd 12871 28 safety safety NN cord-010119-t1x9gknd 12871 29 and and CC cord-010119-t1x9gknd 12871 30 department department NN cord-010119-t1x9gknd 12871 31 efficiency efficiency NN cord-010119-t1x9gknd 12871 32 by by IN cord-010119-t1x9gknd 12871 33 substantially substantially RB cord-010119-t1x9gknd 12871 34 reducing reduce VBG cord-010119-t1x9gknd 12871 35 the the DT cord-010119-t1x9gknd 12871 36 occurrence occurrence NN cord-010119-t1x9gknd 12871 37 of of IN cord-010119-t1x9gknd 12871 38 mislabeled mislabele VBN cord-010119-t1x9gknd 12871 39 specimens specimen NNS cord-010119-t1x9gknd 12871 40 and and CC cord-010119-t1x9gknd 12871 41 negate negate VB cord-010119-t1x9gknd 12871 42 the the DT cord-010119-t1x9gknd 12871 43 need need NN cord-010119-t1x9gknd 12871 44 for for IN cord-010119-t1x9gknd 12871 45 2 2 CD cord-010119-t1x9gknd 12871 46 nd nd NNP cord-010119-t1x9gknd 12871 47 specimen specimen NN cord-010119-t1x9gknd 12871 48 collections collection NNS cord-010119-t1x9gknd 12871 49 , , , cord-010119-t1x9gknd 12871 50 reducing reduce VBG cord-010119-t1x9gknd 12871 51 potential potential JJ cord-010119-t1x9gknd 12871 52 iatrogenic iatrogenic JJ cord-010119-t1x9gknd 12871 53 blood blood NN cord-010119-t1x9gknd 12871 54 loss loss NN cord-010119-t1x9gknd 12871 55 and and CC cord-010119-t1x9gknd 12871 56 improving improve VBG cord-010119-t1x9gknd 12871 57 patient patient JJ cord-010119-t1x9gknd 12871 58 satisfaction satisfaction NN cord-010119-t1x9gknd 12871 59 . . . cord-010119-t1x9gknd 12872 1 Background Background NNP cord-010119-t1x9gknd 12872 2 / / SYM cord-010119-t1x9gknd 12872 3 Case Case NNP cord-010119-t1x9gknd 12872 4 Studies Studies NNPS cord-010119-t1x9gknd 12872 5 : : : cord-010119-t1x9gknd 12873 1 Based base VBN cord-010119-t1x9gknd 12873 2 on on IN cord-010119-t1x9gknd 12873 3 a a DT cord-010119-t1x9gknd 12873 4 few few JJ cord-010119-t1x9gknd 12873 5 small small JJ cord-010119-t1x9gknd 12873 6 randomised randomised JJ cord-010119-t1x9gknd 12873 7 controlled control VBN cord-010119-t1x9gknd 12873 8 trials trial NNS cord-010119-t1x9gknd 12873 9 ( ( -LRB- cord-010119-t1x9gknd 12873 10 RCTs RCTs NNP cord-010119-t1x9gknd 12873 11 ) ) -RRB- cord-010119-t1x9gknd 12873 12 performed perform VBN cord-010119-t1x9gknd 12873 13 in in IN cord-010119-t1x9gknd 12873 14 the the DT cord-010119-t1x9gknd 12873 15 late late JJ cord-010119-t1x9gknd 12873 16 ' ' NNS cord-010119-t1x9gknd 12873 17 90s 90 NNS cord-010119-t1x9gknd 12873 18 and and CC cord-010119-t1x9gknd 12873 19 in in IN cord-010119-t1x9gknd 12873 20 early early JJ cord-010119-t1x9gknd 12873 21 2000 2000 CD cord-010119-t1x9gknd 12873 22 , , , cord-010119-t1x9gknd 12873 23 intravenous intravenous JJ cord-010119-t1x9gknd 12873 24 immunoglobulin immunoglobulin NN cord-010119-t1x9gknd 12873 25 ( ( -LRB- cord-010119-t1x9gknd 12873 26 IVIG IVIG NNP cord-010119-t1x9gknd 12873 27 ) ) -RRB- cord-010119-t1x9gknd 12873 28 use use NN cord-010119-t1x9gknd 12873 29 has have VBZ cord-010119-t1x9gknd 12873 30 been be VBN cord-010119-t1x9gknd 12873 31 suggested suggest VBN cord-010119-t1x9gknd 12873 32 as as IN cord-010119-t1x9gknd 12873 33 a a DT cord-010119-t1x9gknd 12873 34 potential potential JJ cord-010119-t1x9gknd 12873 35 treatment treatment NN cord-010119-t1x9gknd 12873 36 to to TO cord-010119-t1x9gknd 12873 37 avoid avoid VB cord-010119-t1x9gknd 12873 38 exchange exchange NN cord-010119-t1x9gknd 12873 39 transfusion transfusion NN cord-010119-t1x9gknd 12873 40 ( ( -LRB- cord-010119-t1x9gknd 12873 41 ET ET NNP cord-010119-t1x9gknd 12873 42 ) ) -RRB- cord-010119-t1x9gknd 12873 43 for for IN cord-010119-t1x9gknd 12873 44 Rh Rh NNP cord-010119-t1x9gknd 12873 45 hemolytic hemolytic JJ cord-010119-t1x9gknd 12873 46 disease disease NN cord-010119-t1x9gknd 12873 47 of of IN cord-010119-t1x9gknd 12873 48 the the DT cord-010119-t1x9gknd 12873 49 newborn newborn NN cord-010119-t1x9gknd 12873 50 ( ( -LRB- cord-010119-t1x9gknd 12873 51 HDN HDN NNP cord-010119-t1x9gknd 12873 52 ) ) -RRB- cord-010119-t1x9gknd 12873 53 . . . cord-010119-t1x9gknd 12874 1 This this DT cord-010119-t1x9gknd 12874 2 treatment treatment NN cord-010119-t1x9gknd 12874 3 modality modality NN cord-010119-t1x9gknd 12874 4 is be VBZ cord-010119-t1x9gknd 12874 5 now now RB cord-010119-t1x9gknd 12874 6 routinely routinely RB cord-010119-t1x9gknd 12874 7 used use VBN cord-010119-t1x9gknd 12874 8 for for IN cord-010119-t1x9gknd 12874 9 Rh Rh NNP cord-010119-t1x9gknd 12874 10 - - HYPH cord-010119-t1x9gknd 12874 11 HDN HDN NNP cord-010119-t1x9gknd 12874 12 and and CC cord-010119-t1x9gknd 12874 13 has have VBZ cord-010119-t1x9gknd 12874 14 been be VBN cord-010119-t1x9gknd 12874 15 extended extend VBN cord-010119-t1x9gknd 12874 16 to to IN cord-010119-t1x9gknd 12874 17 HDN HDN NNP cord-010119-t1x9gknd 12874 18 caused cause VBN cord-010119-t1x9gknd 12874 19 by by IN cord-010119-t1x9gknd 12874 20 ABO ABO NNP cord-010119-t1x9gknd 12874 21 incompatibility incompatibility NN cord-010119-t1x9gknd 12874 22 or or CC cord-010119-t1x9gknd 12874 23 by by IN cord-010119-t1x9gknd 12874 24 other other JJ cord-010119-t1x9gknd 12874 25 red red JJ cord-010119-t1x9gknd 12874 26 blood blood NN cord-010119-t1x9gknd 12874 27 cell cell NN cord-010119-t1x9gknd 12874 28 antibodies antibody NNS cord-010119-t1x9gknd 12874 29 . . . cord-010119-t1x9gknd 12875 1 However however RB cord-010119-t1x9gknd 12875 2 , , , cord-010119-t1x9gknd 12875 3 larger large JJR cord-010119-t1x9gknd 12875 4 RCTs rct NNS cord-010119-t1x9gknd 12875 5 performed perform VBN cord-010119-t1x9gknd 12875 6 since since IN cord-010119-t1x9gknd 12875 7 2010 2010 CD cord-010119-t1x9gknd 12875 8 have have VBP cord-010119-t1x9gknd 12875 9 shown show VBN cord-010119-t1x9gknd 12875 10 that that IN cord-010119-t1x9gknd 12875 11 prophylactic prophylactic JJ cord-010119-t1x9gknd 12875 12 IVIG IVIG NNP cord-010119-t1x9gknd 12875 13 did do VBD cord-010119-t1x9gknd 12875 14 not not RB cord-010119-t1x9gknd 12875 15 reduce reduce VB cord-010119-t1x9gknd 12875 16 the the DT cord-010119-t1x9gknd 12875 17 need need NN cord-010119-t1x9gknd 12875 18 for for IN cord-010119-t1x9gknd 12875 19 ET ET NNP cord-010119-t1x9gknd 12875 20 , , , cord-010119-t1x9gknd 12875 21 the the DT cord-010119-t1x9gknd 12875 22 duration duration NN cord-010119-t1x9gknd 12875 23 of of IN cord-010119-t1x9gknd 12875 24 hyperbilirubinemia hyperbilirubinemia NN cord-010119-t1x9gknd 12875 25 , , , cord-010119-t1x9gknd 12875 26 the the DT cord-010119-t1x9gknd 12875 27 maximum maximum JJ cord-010119-t1x9gknd 12875 28 bilirubin bilirubin NN cord-010119-t1x9gknd 12875 29 levels level NNS cord-010119-t1x9gknd 12875 30 nor nor CC cord-010119-t1x9gknd 12875 31 the the DT cord-010119-t1x9gknd 12875 32 need need NN cord-010119-t1x9gknd 12875 33 for for IN cord-010119-t1x9gknd 12875 34 top top JJ cord-010119-t1x9gknd 12875 35 - - HYPH cord-010119-t1x9gknd 12875 36 up up RP cord-010119-t1x9gknd 12875 37 red red JJ cord-010119-t1x9gknd 12875 38 blood blood NN cord-010119-t1x9gknd 12875 39 cell cell NN cord-010119-t1x9gknd 12875 40 transfusions transfusion NNS cord-010119-t1x9gknd 12875 41 . . . cord-010119-t1x9gknd 12876 1 The the DT cord-010119-t1x9gknd 12876 2 primary primary JJ cord-010119-t1x9gknd 12876 3 objective objective NN cord-010119-t1x9gknd 12876 4 of of IN cord-010119-t1x9gknd 12876 5 this this DT cord-010119-t1x9gknd 12876 6 study study NN cord-010119-t1x9gknd 12876 7 was be VBD cord-010119-t1x9gknd 12876 8 to to TO cord-010119-t1x9gknd 12876 9 describe describe VB cord-010119-t1x9gknd 12876 10 the the DT cord-010119-t1x9gknd 12876 11 usage usage NN cord-010119-t1x9gknd 12876 12 of of IN cord-010119-t1x9gknd 12876 13 IVIG IVIG NNP cord-010119-t1x9gknd 12876 14 for for IN cord-010119-t1x9gknd 12876 15 HDN HDN NNP cord-010119-t1x9gknd 12876 16 at at IN cord-010119-t1x9gknd 12876 17 a a DT cord-010119-t1x9gknd 12876 18 tertiary tertiary JJ cord-010119-t1x9gknd 12876 19 academic academic JJ cord-010119-t1x9gknd 12876 20 referral referral NN cord-010119-t1x9gknd 12876 21 hospital hospital NN cord-010119-t1x9gknd 12876 22 . . . cord-010119-t1x9gknd 12877 1 Study Study NNP cord-010119-t1x9gknd 12877 2 Design Design NNP cord-010119-t1x9gknd 12877 3 / / SYM cord-010119-t1x9gknd 12877 4 Methods method NNS cord-010119-t1x9gknd 12877 5 : : : cord-010119-t1x9gknd 12877 6 A a DT cord-010119-t1x9gknd 12877 7 retrospective retrospective JJ cord-010119-t1x9gknd 12877 8 chart chart NN cord-010119-t1x9gknd 12877 9 review review NN cord-010119-t1x9gknd 12877 10 was be VBD cord-010119-t1x9gknd 12877 11 performed perform VBN cord-010119-t1x9gknd 12877 12 of of IN cord-010119-t1x9gknd 12877 13 all all DT cord-010119-t1x9gknd 12877 14 neonates neonate NNS cord-010119-t1x9gknd 12877 15 who who WP cord-010119-t1x9gknd 12877 16 received receive VBD cord-010119-t1x9gknd 12877 17 IVIG IVIG NNP cord-010119-t1x9gknd 12877 18 for for IN cord-010119-t1x9gknd 12877 19 HDN HDN NNP cord-010119-t1x9gknd 12877 20 in in IN cord-010119-t1x9gknd 12877 21 the the DT cord-010119-t1x9gknd 12877 22 neonatal neonatal JJ cord-010119-t1x9gknd 12877 23 intensive intensive JJ cord-010119-t1x9gknd 12877 24 care care NN cord-010119-t1x9gknd 12877 25 unit unit NN cord-010119-t1x9gknd 12877 26 ( ( -LRB- cord-010119-t1x9gknd 12877 27 NICU NICU NNP cord-010119-t1x9gknd 12877 28 ) ) -RRB- cord-010119-t1x9gknd 12877 29 from from IN cord-010119-t1x9gknd 12877 30 January January NNP cord-010119-t1x9gknd 12877 31 1 1 CD cord-010119-t1x9gknd 12877 32 , , , cord-010119-t1x9gknd 12877 33 2005 2005 CD cord-010119-t1x9gknd 12877 34 to to IN cord-010119-t1x9gknd 12877 35 June June NNP cord-010119-t1x9gknd 12877 36 30 30 CD cord-010119-t1x9gknd 12877 37 , , , cord-010119-t1x9gknd 12877 38 2016 2016 CD cord-010119-t1x9gknd 12877 39 . . . cord-010119-t1x9gknd 12878 1 Data datum NNS cord-010119-t1x9gknd 12878 2 collected collect VBD cord-010119-t1x9gknd 12878 3 included include VBN cord-010119-t1x9gknd 12878 4 patient patient JJ cord-010119-t1x9gknd 12878 5 demographics demographic NNS cord-010119-t1x9gknd 12878 6 features feature VBZ cord-010119-t1x9gknd 12878 7 and and CC cord-010119-t1x9gknd 12878 8 diagnosis diagnosis NN cord-010119-t1x9gknd 12878 9 , , , cord-010119-t1x9gknd 12878 10 indications indication NNS cord-010119-t1x9gknd 12878 11 for for IN cord-010119-t1x9gknd 12878 12 IVIG IVIG NNP cord-010119-t1x9gknd 12878 13 , , , cord-010119-t1x9gknd 12878 14 neonatal neonatal JJ cord-010119-t1x9gknd 12878 15 laboratory laboratory NN cord-010119-t1x9gknd 12878 16 results result NNS cord-010119-t1x9gknd 12878 17 , , , cord-010119-t1x9gknd 12878 18 treatment treatment NN cord-010119-t1x9gknd 12878 19 details detail NNS cord-010119-t1x9gknd 12878 20 , , , cord-010119-t1x9gknd 12878 21 adverse adverse JJ cord-010119-t1x9gknd 12878 22 events event NNS cord-010119-t1x9gknd 12878 23 and and CC cord-010119-t1x9gknd 12878 24 patient patient JJ cord-010119-t1x9gknd 12878 25 outcomes outcome NNS cord-010119-t1x9gknd 12878 26 . . . cord-010119-t1x9gknd 12879 1 Results result NNS cord-010119-t1x9gknd 12879 2 / / SYM cord-010119-t1x9gknd 12879 3 Findings finding NNS cord-010119-t1x9gknd 12879 4 : : : cord-010119-t1x9gknd 12879 5 Ninety ninety CD cord-010119-t1x9gknd 12879 6 - - HYPH cord-010119-t1x9gknd 12879 7 seven seven CD cord-010119-t1x9gknd 12879 8 neonates neonate NNS cord-010119-t1x9gknd 12879 9 received receive VBD cord-010119-t1x9gknd 12879 10 IVIG IVIG NNP cord-010119-t1x9gknd 12879 11 during during IN cord-010119-t1x9gknd 12879 12 the the DT cord-010119-t1x9gknd 12879 13 study study NN cord-010119-t1x9gknd 12879 14 period period NN cord-010119-t1x9gknd 12879 15 : : : cord-010119-t1x9gknd 12879 16 57 57 CD cord-010119-t1x9gknd 12879 17 % % NN cord-010119-t1x9gknd 12879 18 were be VBD cord-010119-t1x9gknd 12879 19 female female JJ cord-010119-t1x9gknd 12879 20 and and CC cord-010119-t1x9gknd 12879 21 7 7 CD cord-010119-t1x9gknd 12879 22 % % NN cord-010119-t1x9gknd 12879 23 were be VBD cord-010119-t1x9gknd 12879 24 less less JJR cord-010119-t1x9gknd 12879 25 than than IN cord-010119-t1x9gknd 12879 26 34 34 CD cord-010119-t1x9gknd 12879 27 weeks week NNS cord-010119-t1x9gknd 12879 28 of of IN cord-010119-t1x9gknd 12879 29 gestational gestational JJ cord-010119-t1x9gknd 12879 30 age age NN cord-010119-t1x9gknd 12879 31 . . . cord-010119-t1x9gknd 12880 1 None none NN cord-010119-t1x9gknd 12880 2 had have VBD cord-010119-t1x9gknd 12880 3 co co VBN cord-010119-t1x9gknd 12880 4 - - JJ cord-010119-t1x9gknd 12880 5 existing existing JJ cord-010119-t1x9gknd 12880 6 G6PD G6PD NNP cord-010119-t1x9gknd 12880 7 deficiency deficiency NN cord-010119-t1x9gknd 12880 8 , , , cord-010119-t1x9gknd 12880 9 pyruvate pyruvate NN cord-010119-t1x9gknd 12880 10 kinase kinase NN cord-010119-t1x9gknd 12880 11 deficiency deficiency NN cord-010119-t1x9gknd 12880 12 or or CC cord-010119-t1x9gknd 12880 13 spherocytosis spherocytosis NN cord-010119-t1x9gknd 12880 14 . . . cord-010119-t1x9gknd 12881 1 All all DT cord-010119-t1x9gknd 12881 2 neonates neonate NNS cord-010119-t1x9gknd 12881 3 received receive VBD cord-010119-t1x9gknd 12881 4 phototherapy phototherapy NN cord-010119-t1x9gknd 12881 5 prior prior RB cord-010119-t1x9gknd 12881 6 to to IN cord-010119-t1x9gknd 12881 7 IVIG IVIG NNP cord-010119-t1x9gknd 12881 8 treatment treatment NN cord-010119-t1x9gknd 12881 9 . . . cord-010119-t1x9gknd 12882 1 Indications indication NNS cord-010119-t1x9gknd 12882 2 for for IN cord-010119-t1x9gknd 12882 3 IVIG IVIG NNP cord-010119-t1x9gknd 12882 4 were be VBD cord-010119-t1x9gknd 12882 5 ABO ABO NNP cord-010119-t1x9gknd 12882 6 - - HYPH cord-010119-t1x9gknd 12882 7 HDN HDN NNP cord-010119-t1x9gknd 12882 8 ( ( -LRB- cord-010119-t1x9gknd 12882 9 41 41 CD cord-010119-t1x9gknd 12882 10 % % NN cord-010119-t1x9gknd 12882 11 ) ) -RRB- cord-010119-t1x9gknd 12882 12 and and CC cord-010119-t1x9gknd 12882 13 Rhesus Rhesus NNP cord-010119-t1x9gknd 12882 14 - - HYPH cord-010119-t1x9gknd 12882 15 HDN HDN NNP cord-010119-t1x9gknd 12882 16 ( ( -LRB- cord-010119-t1x9gknd 12882 17 59 59 CD cord-010119-t1x9gknd 12882 18 % % NN cord-010119-t1x9gknd 12882 19 ) ) -RRB- cord-010119-t1x9gknd 12882 20 . . . cord-010119-t1x9gknd 12883 1 Antibodies antibody NNS cord-010119-t1x9gknd 12883 2 most most RBS cord-010119-t1x9gknd 12883 3 often often RB cord-010119-t1x9gknd 12883 4 implicated implicate VBN cord-010119-t1x9gknd 12883 5 in in IN cord-010119-t1x9gknd 12883 6 Rh Rh NNP cord-010119-t1x9gknd 12883 7 - - HYPH cord-010119-t1x9gknd 12883 8 HDN HDN NNP cord-010119-t1x9gknd 12883 9 were be VBD cord-010119-t1x9gknd 12883 10 anti anti JJ cord-010119-t1x9gknd 12883 11 - - JJ cord-010119-t1x9gknd 12883 12 D d JJ cord-010119-t1x9gknd 12883 13 ( ( -LRB- cord-010119-t1x9gknd 12883 14 22/57 22/57 CD cord-010119-t1x9gknd 12883 15 ) ) -RRB- cord-010119-t1x9gknd 12883 16 , , , cord-010119-t1x9gknd 12883 17 anti anti JJ cord-010119-t1x9gknd 12883 18 - - JJ cord-010119-t1x9gknd 12883 19 D d JJ cord-010119-t1x9gknd 12883 20 and and CC cord-010119-t1x9gknd 12883 21 anti anti JJ cord-010119-t1x9gknd 12883 22 - - JJ cord-010119-t1x9gknd 12883 23 C c JJ cord-010119-t1x9gknd 12883 24 ( ( -LRB- cord-010119-t1x9gknd 12883 25 22/57 22/57 CD cord-010119-t1x9gknd 12883 26 ) ) -RRB- cord-010119-t1x9gknd 12883 27 and and CC cord-010119-t1x9gknd 12883 28 anti anti JJ cord-010119-t1x9gknd 12883 29 - - NN cord-010119-t1x9gknd 12883 30 c c JJ cord-010119-t1x9gknd 12883 31 ( ( -LRB- cord-010119-t1x9gknd 12883 32 5/57 5/57 CD cord-010119-t1x9gknd 12883 33 ) ) -RRB- cord-010119-t1x9gknd 12883 34 . . . cord-010119-t1x9gknd 12884 1 Sixteen sixteen CD cord-010119-t1x9gknd 12884 2 infants infant NNS cord-010119-t1x9gknd 12884 3 with with IN cord-010119-t1x9gknd 12884 4 Rh Rh NNP cord-010119-t1x9gknd 12884 5 - - HYPH cord-010119-t1x9gknd 12884 6 HDN HDN NNP cord-010119-t1x9gknd 12884 7 had have VBD cord-010119-t1x9gknd 12884 8 received receive VBN cord-010119-t1x9gknd 12884 9 intrauterine intrauterine JJ cord-010119-t1x9gknd 12884 10 transfusions transfusion NNS cord-010119-t1x9gknd 12884 11 . . . cord-010119-t1x9gknd 12885 1 The the DT cord-010119-t1x9gknd 12885 2 mean mean JJ cord-010119-t1x9gknd 12885 3 cumulative cumulative JJ cord-010119-t1x9gknd 12885 4 dose dose NN cord-010119-t1x9gknd 12885 5 of of IN cord-010119-t1x9gknd 12885 6 IVIG IVIG NNP cord-010119-t1x9gknd 12885 7 was be VBD cord-010119-t1x9gknd 12885 8 1 1 CD cord-010119-t1x9gknd 12885 9 g g NN cord-010119-t1x9gknd 12885 10 / / SYM cord-010119-t1x9gknd 12885 11 kg kg NN cord-010119-t1x9gknd 12885 12 ( ( -LRB- cord-010119-t1x9gknd 12885 13 range range NN cord-010119-t1x9gknd 12885 14 from from IN cord-010119-t1x9gknd 12885 15 0,3 0,3 CD cord-010119-t1x9gknd 12885 16 g g NN cord-010119-t1x9gknd 12885 17 / / SYM cord-010119-t1x9gknd 12885 18 kg kg NN cord-010119-t1x9gknd 12885 19 to to IN cord-010119-t1x9gknd 12885 20 3,8 3,8 CD cord-010119-t1x9gknd 12885 21 g g NN cord-010119-t1x9gknd 12885 22 / / SYM cord-010119-t1x9gknd 12885 23 kg kg NNP cord-010119-t1x9gknd 12885 24 ) ) -RRB- cord-010119-t1x9gknd 12885 25 . . . cord-010119-t1x9gknd 12886 1 Neonates Neonates NNP cord-010119-t1x9gknd 12886 2 received receive VBD cord-010119-t1x9gknd 12886 3 one one CD cord-010119-t1x9gknd 12886 4 to to IN cord-010119-t1x9gknd 12886 5 four four CD cord-010119-t1x9gknd 12886 6 IVIG IVIG NNP cord-010119-t1x9gknd 12886 7 administrations administration NNS cord-010119-t1x9gknd 12886 8 . . . cord-010119-t1x9gknd 12887 1 Table table NN cord-010119-t1x9gknd 12887 2 1 1 CD cord-010119-t1x9gknd 12887 3 shows show VBZ cord-010119-t1x9gknd 12887 4 the the DT cord-010119-t1x9gknd 12887 5 number number NN cord-010119-t1x9gknd 12887 6 of of IN cord-010119-t1x9gknd 12887 7 patients patient NNS cord-010119-t1x9gknd 12887 8 receiving receive VBG cord-010119-t1x9gknd 12887 9 IVIG IVIG NNP cord-010119-t1x9gknd 12887 10 during during IN cord-010119-t1x9gknd 12887 11 two two CD cord-010119-t1x9gknd 12887 12 time time NN cord-010119-t1x9gknd 12887 13 periods period NNS cord-010119-t1x9gknd 12887 14 . . . cord-010119-t1x9gknd 12888 1 Three three CD cord-010119-t1x9gknd 12888 2 adverse adverse JJ cord-010119-t1x9gknd 12888 3 reactions reaction NNS cord-010119-t1x9gknd 12888 4 were be VBD cord-010119-t1x9gknd 12888 5 noted note VBN cord-010119-t1x9gknd 12888 6 during during IN cord-010119-t1x9gknd 12888 7 IVIG IVIG NNP cord-010119-t1x9gknd 12888 8 administration administration NN cord-010119-t1x9gknd 12888 9 : : : cord-010119-t1x9gknd 12888 10 cutaneous cutaneous JJ cord-010119-t1x9gknd 12888 11 rash rash NN cord-010119-t1x9gknd 12888 12 , , , cord-010119-t1x9gknd 12888 13 hypotension hypotension NN cord-010119-t1x9gknd 12888 14 and and CC cord-010119-t1x9gknd 12888 15 fever fever NN cord-010119-t1x9gknd 12888 16 . . . cord-010119-t1x9gknd 12889 1 Of of IN cord-010119-t1x9gknd 12889 2 all all DT cord-010119-t1x9gknd 12889 3 neonates neonate NNS cord-010119-t1x9gknd 12889 4 , , , cord-010119-t1x9gknd 12889 5 14 14 CD cord-010119-t1x9gknd 12889 6 required require VBD cord-010119-t1x9gknd 12889 7 an an DT cord-010119-t1x9gknd 12889 8 ET ET NNP cord-010119-t1x9gknd 12889 9 for for IN cord-010119-t1x9gknd 12889 10 Rh Rh NNP cord-010119-t1x9gknd 12889 11 - - HYPH cord-010119-t1x9gknd 12889 12 HDN HDN NNP cord-010119-t1x9gknd 12889 13 and and CC cord-010119-t1x9gknd 12889 14 3 3 CD cord-010119-t1x9gknd 12889 15 for for IN cord-010119-t1x9gknd 12889 16 ABO ABO NNP cord-010119-t1x9gknd 12889 17 - - HYPH cord-010119-t1x9gknd 12889 18 HDN HDN NNP cord-010119-t1x9gknd 12889 19 . . . cord-010119-t1x9gknd 12890 1 Forty forty CD cord-010119-t1x9gknd 12890 2 - - HYPH cord-010119-t1x9gknd 12890 3 five five CD cord-010119-t1x9gknd 12890 4 ( ( -LRB- cord-010119-t1x9gknd 12890 5 46 46 CD cord-010119-t1x9gknd 12890 6 % % NN cord-010119-t1x9gknd 12890 7 ) ) -RRB- cord-010119-t1x9gknd 12890 8 patients patient NNS cord-010119-t1x9gknd 12890 9 needed need VBD cord-010119-t1x9gknd 12890 10 top top JJ cord-010119-t1x9gknd 12890 11 - - HYPH cord-010119-t1x9gknd 12890 12 up up RP cord-010119-t1x9gknd 12890 13 transfusions transfusion NNS cord-010119-t1x9gknd 12890 14 during during IN cord-010119-t1x9gknd 12890 15 hospitalisation hospitalisation NN cord-010119-t1x9gknd 12890 16 and and CC cord-010119-t1x9gknd 12890 17 until until IN cord-010119-t1x9gknd 12890 18 three three CD cord-010119-t1x9gknd 12890 19 months month NNS cord-010119-t1x9gknd 12890 20 of of IN cord-010119-t1x9gknd 12890 21 age age NN cord-010119-t1x9gknd 12890 22 : : : cord-010119-t1x9gknd 12890 23 8 8 CD cord-010119-t1x9gknd 12890 24 with with IN cord-010119-t1x9gknd 12890 25 ABO ABO NNP cord-010119-t1x9gknd 12890 26 - - HYPH cord-010119-t1x9gknd 12890 27 HDN HDN NNP cord-010119-t1x9gknd 12890 28 and and CC cord-010119-t1x9gknd 12890 29 37 37 CD cord-010119-t1x9gknd 12890 30 with with IN cord-010119-t1x9gknd 12890 31 Rh Rh NNP cord-010119-t1x9gknd 12890 32 - - HYPH cord-010119-t1x9gknd 12890 33 HDN HDN NNP cord-010119-t1x9gknd 12890 34 . . . cord-010119-t1x9gknd 12891 1 The the DT cord-010119-t1x9gknd 12891 2 mean mean JJ cord-010119-t1x9gknd 12891 3 number number NN cord-010119-t1x9gknd 12891 4 of of IN cord-010119-t1x9gknd 12891 5 transfusions transfusion NNS cord-010119-t1x9gknd 12891 6 was be VBD cord-010119-t1x9gknd 12891 7 three three CD cord-010119-t1x9gknd 12891 8 ( ( -LRB- cord-010119-t1x9gknd 12891 9 range:1 range:1 NN cord-010119-t1x9gknd 12891 10 to to IN cord-010119-t1x9gknd 12891 11 7 7 CD cord-010119-t1x9gknd 12891 12 ) ) -RRB- cord-010119-t1x9gknd 12891 13 . . . cord-010119-t1x9gknd 12892 1 Conclusion conclusion NN cord-010119-t1x9gknd 12892 2 : : : cord-010119-t1x9gknd 12893 1 Although although IN cord-010119-t1x9gknd 12893 2 initially initially RB cord-010119-t1x9gknd 12893 3 described describe VBN cord-010119-t1x9gknd 12893 4 for for IN cord-010119-t1x9gknd 12893 5 RH RH NNP cord-010119-t1x9gknd 12893 6 - - HYPH cord-010119-t1x9gknd 12893 7 HDN HDN NNP cord-010119-t1x9gknd 12893 8 , , , cord-010119-t1x9gknd 12893 9 ABO ABO NNP cord-010119-t1x9gknd 12893 10 - - HYPH cord-010119-t1x9gknd 12893 11 HDN HDN NNP cord-010119-t1x9gknd 12893 12 is be VBZ cord-010119-t1x9gknd 12893 13 now now RB cord-010119-t1x9gknd 12893 14 one one CD cord-010119-t1x9gknd 12893 15 of of IN cord-010119-t1x9gknd 12893 16 the the DT cord-010119-t1x9gknd 12893 17 most most RBS cord-010119-t1x9gknd 12893 18 frequent frequent JJ cord-010119-t1x9gknd 12893 19 indications indication NNS cord-010119-t1x9gknd 12893 20 for for IN cord-010119-t1x9gknd 12893 21 IVIG IVIG NNP cord-010119-t1x9gknd 12893 22 in in IN cord-010119-t1x9gknd 12893 23 neonates neonate NNS cord-010119-t1x9gknd 12893 24 . . . cord-010119-t1x9gknd 12894 1 The the DT cord-010119-t1x9gknd 12894 2 optimal optimal JJ cord-010119-t1x9gknd 12894 3 use use NN cord-010119-t1x9gknd 12894 4 of of IN cord-010119-t1x9gknd 12894 5 IVIG IVIG NNP cord-010119-t1x9gknd 12894 6 in in IN cord-010119-t1x9gknd 12894 7 ABO ABO NNP cord-010119-t1x9gknd 12894 8 - - HYPH cord-010119-t1x9gknd 12894 9 HDN HDN NNP cord-010119-t1x9gknd 12894 10 needs need VBZ cord-010119-t1x9gknd 12894 11 to to TO cord-010119-t1x9gknd 12894 12 be be VB cord-010119-t1x9gknd 12894 13 better well RBR cord-010119-t1x9gknd 12894 14 characterized characterize VBN cord-010119-t1x9gknd 12894 15 . . . cord-010119-t1x9gknd 12895 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12895 2 study study NN cord-010119-t1x9gknd 12895 3 shows show VBZ cord-010119-t1x9gknd 12895 4 a a DT cord-010119-t1x9gknd 12895 5 wide wide JJ cord-010119-t1x9gknd 12895 6 variation variation NN cord-010119-t1x9gknd 12895 7 of of IN cord-010119-t1x9gknd 12895 8 IVIG IVIG NNP cord-010119-t1x9gknd 12895 9 dosing dosing NN cord-010119-t1x9gknd 12895 10 and and CC cord-010119-t1x9gknd 12895 11 a a DT cord-010119-t1x9gknd 12895 12 significant significant JJ cord-010119-t1x9gknd 12895 13 proportion proportion NN cord-010119-t1x9gknd 12895 14 of of IN cord-010119-t1x9gknd 12895 15 neonates neonate NNS cord-010119-t1x9gknd 12895 16 requiring require VBG cord-010119-t1x9gknd 12895 17 top top JJ cord-010119-t1x9gknd 12895 18 - - HYPH cord-010119-t1x9gknd 12895 19 up up RP cord-010119-t1x9gknd 12895 20 transfusions transfusion NNS cord-010119-t1x9gknd 12895 21 . . . cord-010119-t1x9gknd 12896 1 Further further JJ cord-010119-t1x9gknd 12896 2 research research NN cord-010119-t1x9gknd 12896 3 is be VBZ cord-010119-t1x9gknd 12896 4 required require VBN cord-010119-t1x9gknd 12896 5 to to TO cord-010119-t1x9gknd 12896 6 evaluate evaluate VB cord-010119-t1x9gknd 12896 7 whether whether IN cord-010119-t1x9gknd 12896 8 anemia anemia NN cord-010119-t1x9gknd 12896 9 in in IN cord-010119-t1x9gknd 12896 10 ABO ABO NNP cord-010119-t1x9gknd 12896 11 - - HYPH cord-010119-t1x9gknd 12896 12 HDN HDN NNP cord-010119-t1x9gknd 12896 13 might may MD cord-010119-t1x9gknd 12896 14 be be VB cord-010119-t1x9gknd 12896 15 exacerbated exacerbate VBN cord-010119-t1x9gknd 12896 16 by by IN cord-010119-t1x9gknd 12896 17 hemolysis hemolysis NN cord-010119-t1x9gknd 12896 18 from from IN cord-010119-t1x9gknd 12896 19 IVIG IVIG NNP cord-010119-t1x9gknd 12896 20 isohemagglutinins isohemagglutinin NNS cord-010119-t1x9gknd 12896 21 and and CC cord-010119-t1x9gknd 12896 22 if if IN cord-010119-t1x9gknd 12896 23 it -PRON- PRP cord-010119-t1x9gknd 12896 24 is be VBZ cord-010119-t1x9gknd 12896 25 dose dose NN cord-010119-t1x9gknd 12896 26 - - HYPH cord-010119-t1x9gknd 12896 27 dependent dependent JJ cord-010119-t1x9gknd 12896 28 . . . cord-010119-t1x9gknd 12897 1 Background Background NNP cord-010119-t1x9gknd 12897 2 / / SYM cord-010119-t1x9gknd 12897 3 Case Case NNP cord-010119-t1x9gknd 12897 4 Studies Studies NNPS cord-010119-t1x9gknd 12897 5 : : : cord-010119-t1x9gknd 12897 6 Background background NN cord-010119-t1x9gknd 12897 7 : : : cord-010119-t1x9gknd 12898 1 One one CD cord-010119-t1x9gknd 12898 2 of of IN cord-010119-t1x9gknd 12898 3 the the DT cord-010119-t1x9gknd 12898 4 most most RBS cord-010119-t1x9gknd 12898 5 serious serious JJ cord-010119-t1x9gknd 12898 6 adverse adverse JJ cord-010119-t1x9gknd 12898 7 reactions reaction NNS cord-010119-t1x9gknd 12898 8 to to IN cord-010119-t1x9gknd 12898 9 transfusion transfusion NN cord-010119-t1x9gknd 12898 10 is be VBZ cord-010119-t1x9gknd 12898 11 the the DT cord-010119-t1x9gknd 12898 12 development development NN cord-010119-t1x9gknd 12898 13 of of IN cord-010119-t1x9gknd 12898 14 graft graft NN cord-010119-t1x9gknd 12898 15 versus versus IN cord-010119-t1x9gknd 12898 16 host host NN cord-010119-t1x9gknd 12898 17 disease disease NN cord-010119-t1x9gknd 12898 18 . . . cord-010119-t1x9gknd 12899 1 Symptoms symptom NNS cord-010119-t1x9gknd 12899 2 include include VBP cord-010119-t1x9gknd 12899 3 the the DT cord-010119-t1x9gknd 12899 4 development development NN cord-010119-t1x9gknd 12899 5 of of IN cord-010119-t1x9gknd 12899 6 a a DT cord-010119-t1x9gknd 12899 7 characteristic characteristic JJ cord-010119-t1x9gknd 12899 8 cutaneous cutaneous JJ cord-010119-t1x9gknd 12899 9 rash rash NN cord-010119-t1x9gknd 12899 10 , , , cord-010119-t1x9gknd 12899 11 enteritis enteritis NN cord-010119-t1x9gknd 12899 12 often often RB cord-010119-t1x9gknd 12899 13 resulting result VBG cord-010119-t1x9gknd 12899 14 in in IN cord-010119-t1x9gknd 12899 15 watery watery JJ cord-010119-t1x9gknd 12899 16 diarrhea diarrhea NN cord-010119-t1x9gknd 12899 17 , , , cord-010119-t1x9gknd 12899 18 elevated elevated JJ cord-010119-t1x9gknd 12899 19 liver liver NN cord-010119-t1x9gknd 12899 20 function function NN cord-010119-t1x9gknd 12899 21 tests test NNS cord-010119-t1x9gknd 12899 22 and and CC cord-010119-t1x9gknd 12899 23 ultimately ultimately RB cord-010119-t1x9gknd 12899 24 pancytopenia pancytopenia NNP cord-010119-t1x9gknd 12899 25 . . . cord-010119-t1x9gknd 12900 1 The the DT cord-010119-t1x9gknd 12900 2 clinical clinical JJ cord-010119-t1x9gknd 12900 3 course course NN cord-010119-t1x9gknd 12900 4 is be VBZ cord-010119-t1x9gknd 12900 5 rapid rapid JJ cord-010119-t1x9gknd 12900 6 with with IN cord-010119-t1x9gknd 12900 7 an an DT cord-010119-t1x9gknd 12900 8 over over IN cord-010119-t1x9gknd 12900 9 90 90 CD cord-010119-t1x9gknd 12900 10 % % NN cord-010119-t1x9gknd 12900 11 case case NN cord-010119-t1x9gknd 12900 12 fatality fatality NN cord-010119-t1x9gknd 12900 13 rate rate NN cord-010119-t1x9gknd 12900 14 . . . cord-010119-t1x9gknd 12901 1 The the DT cord-010119-t1x9gknd 12901 2 patient patient JJ cord-010119-t1x9gknd 12901 3 population population NN cord-010119-t1x9gknd 12901 4 at at IN cord-010119-t1x9gknd 12901 5 risk risk NN cord-010119-t1x9gknd 12901 6 is be VBZ cord-010119-t1x9gknd 12901 7 reasonably reasonably RB cord-010119-t1x9gknd 12901 8 well well RB cord-010119-t1x9gknd 12901 9 - - HYPH cord-010119-t1x9gknd 12901 10 defined define VBN cord-010119-t1x9gknd 12901 11 including include VBG cord-010119-t1x9gknd 12901 12 patients patient NNS cord-010119-t1x9gknd 12901 13 who who WP cord-010119-t1x9gknd 12901 14 are be VBP cord-010119-t1x9gknd 12901 15 immunocompromised immunocompromised JJ cord-010119-t1x9gknd 12901 16 due due IN cord-010119-t1x9gknd 12901 17 to to IN cord-010119-t1x9gknd 12901 18 disease disease NN cord-010119-t1x9gknd 12901 19 process process NN cord-010119-t1x9gknd 12901 20 or or CC cord-010119-t1x9gknd 12901 21 therapy therapy NN cord-010119-t1x9gknd 12901 22 , , , cord-010119-t1x9gknd 12901 23 the the DT cord-010119-t1x9gknd 12901 24 fetus fetus NN cord-010119-t1x9gknd 12901 25 and and CC cord-010119-t1x9gknd 12901 26 low low JJ cord-010119-t1x9gknd 12901 27 birth birth NN cord-010119-t1x9gknd 12901 28 - - HYPH cord-010119-t1x9gknd 12901 29 weight weight NN cord-010119-t1x9gknd 12901 30 neonates neonate NNS cord-010119-t1x9gknd 12901 31 , , , cord-010119-t1x9gknd 12901 32 recipients recipient NNS cord-010119-t1x9gknd 12901 33 of of IN cord-010119-t1x9gknd 12901 34 HLA HLA NNP cord-010119-t1x9gknd 12901 35 - - HYPH cord-010119-t1x9gknd 12901 36 matched match VBN cord-010119-t1x9gknd 12901 37 cellular cellular JJ cord-010119-t1x9gknd 12901 38 blood blood NN cord-010119-t1x9gknd 12901 39 products product NNS cord-010119-t1x9gknd 12901 40 and and CC cord-010119-t1x9gknd 12901 41 the the DT cord-010119-t1x9gknd 12901 42 recipients recipient NNS cord-010119-t1x9gknd 12901 43 of of IN cord-010119-t1x9gknd 12901 44 cellular cellular JJ cord-010119-t1x9gknd 12901 45 blood blood NN cord-010119-t1x9gknd 12901 46 products product NNS cord-010119-t1x9gknd 12901 47 donated donate VBN cord-010119-t1x9gknd 12901 48 by by IN cord-010119-t1x9gknd 12901 49 blood blood NN cord-010119-t1x9gknd 12901 50 relatives relative NNS cord-010119-t1x9gknd 12901 51 . . . cord-010119-t1x9gknd 12902 1 The the DT cord-010119-t1x9gknd 12902 2 basic basic JJ cord-010119-t1x9gknd 12902 3 etiology etiology NN cord-010119-t1x9gknd 12902 4 of of IN cord-010119-t1x9gknd 12902 5 TA TA NNP cord-010119-t1x9gknd 12902 6 - - HYPH cord-010119-t1x9gknd 12902 7 GVHD GVHD NNP cord-010119-t1x9gknd 12902 8 is be VBZ cord-010119-t1x9gknd 12902 9 the the DT cord-010119-t1x9gknd 12902 10 inability inability NN cord-010119-t1x9gknd 12902 11 of of IN cord-010119-t1x9gknd 12902 12 the the DT cord-010119-t1x9gknd 12902 13 transfusion transfusion NN cord-010119-t1x9gknd 12902 14 recipient recipient NN cord-010119-t1x9gknd 12902 15 to to TO cord-010119-t1x9gknd 12902 16 mount mount VB cord-010119-t1x9gknd 12902 17 an an DT cord-010119-t1x9gknd 12902 18 effective effective JJ cord-010119-t1x9gknd 12902 19 immune immune JJ cord-010119-t1x9gknd 12902 20 response response NN cord-010119-t1x9gknd 12902 21 against against IN cord-010119-t1x9gknd 12902 22 donor donor NN cord-010119-t1x9gknd 12902 23 T t NN cord-010119-t1x9gknd 12902 24 - - HYPH cord-010119-t1x9gknd 12902 25 lymphocytes lymphocyte NNS cord-010119-t1x9gknd 12902 26 . . . cord-010119-t1x9gknd 12903 1 Treatment treatment NN cord-010119-t1x9gknd 12903 2 options option NNS cord-010119-t1x9gknd 12903 3 for for IN cord-010119-t1x9gknd 12903 4 TA TA NNP cord-010119-t1x9gknd 12903 5 - - HYPH cord-010119-t1x9gknd 12903 6 GVHD GVHD NNP cord-010119-t1x9gknd 12903 7 are be VBP cord-010119-t1x9gknd 12903 8 ineffective ineffective JJ cord-010119-t1x9gknd 12903 9 , , , cord-010119-t1x9gknd 12903 10 making make VBG cord-010119-t1x9gknd 12903 11 it -PRON- PRP cord-010119-t1x9gknd 12903 12 imperative imperative JJ cord-010119-t1x9gknd 12903 13 that that IN cord-010119-t1x9gknd 12903 14 cellular cellular JJ cord-010119-t1x9gknd 12903 15 blood blood NN cord-010119-t1x9gknd 12903 16 components component NNS cord-010119-t1x9gknd 12903 17 be be VB cord-010119-t1x9gknd 12903 18 irradiated irradiate VBN cord-010119-t1x9gknd 12903 19 prior prior RB cord-010119-t1x9gknd 12903 20 to to IN cord-010119-t1x9gknd 12903 21 transfusion transfusion NN cord-010119-t1x9gknd 12903 22 which which WDT cord-010119-t1x9gknd 12903 23 virtually virtually RB cord-010119-t1x9gknd 12903 24 eliminates eliminate VBZ cord-010119-t1x9gknd 12903 25 the the DT cord-010119-t1x9gknd 12903 26 risk risk NN cord-010119-t1x9gknd 12903 27 of of IN cord-010119-t1x9gknd 12903 28 the the DT cord-010119-t1x9gknd 12903 29 complication complication NN cord-010119-t1x9gknd 12903 30 . . . cord-010119-t1x9gknd 12904 1 Study Study NNP cord-010119-t1x9gknd 12904 2 Design Design NNP cord-010119-t1x9gknd 12904 3 / / SYM cord-010119-t1x9gknd 12904 4 Methods method NNS cord-010119-t1x9gknd 12904 5 : : : cord-010119-t1x9gknd 12905 1 Most Most JJS cord-010119-t1x9gknd 12905 2 transfusion transfusion NN cord-010119-t1x9gknd 12905 3 service service NN cord-010119-t1x9gknd 12905 4 information information NN cord-010119-t1x9gknd 12905 5 systems system NNS cord-010119-t1x9gknd 12905 6 have have VBP cord-010119-t1x9gknd 12905 7 mechanisms mechanism NNS cord-010119-t1x9gknd 12905 8 to to TO cord-010119-t1x9gknd 12905 9 alert alert VB cord-010119-t1x9gknd 12905 10 transfusion transfusion NN cord-010119-t1x9gknd 12905 11 service service NN cord-010119-t1x9gknd 12905 12 staff staff NN cord-010119-t1x9gknd 12905 13 to to IN cord-010119-t1x9gknd 12905 14 patients patient NNS cord-010119-t1x9gknd 12905 15 who who WP cord-010119-t1x9gknd 12905 16 have have VBP cord-010119-t1x9gknd 12905 17 been be VBN cord-010119-t1x9gknd 12905 18 previously previously RB cord-010119-t1x9gknd 12905 19 identified identify VBN cord-010119-t1x9gknd 12905 20 as as IN cord-010119-t1x9gknd 12905 21 needing need VBG cord-010119-t1x9gknd 12905 22 irradiated irradiate VBN cord-010119-t1x9gknd 12905 23 blood blood NN cord-010119-t1x9gknd 12905 24 components component NNS cord-010119-t1x9gknd 12905 25 . . . cord-010119-t1x9gknd 12906 1 However however RB cord-010119-t1x9gknd 12906 2 , , , cord-010119-t1x9gknd 12906 3 if if IN cord-010119-t1x9gknd 12906 4 these these DT cord-010119-t1x9gknd 12906 5 patients patient NNS cord-010119-t1x9gknd 12906 6 are be VBP cord-010119-t1x9gknd 12906 7 not not RB cord-010119-t1x9gknd 12906 8 identified identify VBN cord-010119-t1x9gknd 12906 9 to to IN cord-010119-t1x9gknd 12906 10 the the DT cord-010119-t1x9gknd 12906 11 transfusion transfusion NN cord-010119-t1x9gknd 12906 12 service service NN cord-010119-t1x9gknd 12906 13 at at IN cord-010119-t1x9gknd 12906 14 the the DT cord-010119-t1x9gknd 12906 15 time time NN cord-010119-t1x9gknd 12906 16 of of IN cord-010119-t1x9gknd 12906 17 the the DT cord-010119-t1x9gknd 12906 18 initial initial JJ cord-010119-t1x9gknd 12906 19 hospital hospital NN cord-010119-t1x9gknd 12906 20 visit visit NN cord-010119-t1x9gknd 12906 21 or or CC cord-010119-t1x9gknd 12906 22 the the DT cord-010119-t1x9gknd 12906 23 time time NN cord-010119-t1x9gknd 12906 24 at at IN cord-010119-t1x9gknd 12906 25 which which WDT cord-010119-t1x9gknd 12906 26 the the DT cord-010119-t1x9gknd 12906 27 qualifying qualify VBG cord-010119-t1x9gknd 12906 28 diagnosis diagnosis NN cord-010119-t1x9gknd 12906 29 , , , cord-010119-t1x9gknd 12906 30 these these DT cord-010119-t1x9gknd 12906 31 patients patient NNS cord-010119-t1x9gknd 12906 32 can can MD cord-010119-t1x9gknd 12906 33 erroneously erroneously RB cord-010119-t1x9gknd 12906 34 receive receive VB cord-010119-t1x9gknd 12906 35 non non JJ cord-010119-t1x9gknd 12906 36 - - JJ cord-010119-t1x9gknd 12906 37 irradiated irradiated JJ cord-010119-t1x9gknd 12906 38 blood blood NN cord-010119-t1x9gknd 12906 39 components component NNS cord-010119-t1x9gknd 12906 40 . . . cord-010119-t1x9gknd 12907 1 Following follow VBG cord-010119-t1x9gknd 12907 2 a a DT cord-010119-t1x9gknd 12907 3 " " `` cord-010119-t1x9gknd 12907 4 near near JJ cord-010119-t1x9gknd 12907 5 - - HYPH cord-010119-t1x9gknd 12907 6 miss miss NN cord-010119-t1x9gknd 12907 7 " " '' cord-010119-t1x9gknd 12907 8 situation situation NN cord-010119-t1x9gknd 12907 9 , , , cord-010119-t1x9gknd 12907 10 our -PRON- PRP$ cord-010119-t1x9gknd 12907 11 hospital hospital NN cord-010119-t1x9gknd 12907 12 information information NN cord-010119-t1x9gknd 12907 13 department department NNP cord-010119-t1x9gknd 12907 14 developed develop VBD cord-010119-t1x9gknd 12907 15 a a DT cord-010119-t1x9gknd 12907 16 4-part 4-part CD cord-010119-t1x9gknd 12907 17 program program NN cord-010119-t1x9gknd 12907 18 to to TO cord-010119-t1x9gknd 12907 19 minimize minimize VB cord-010119-t1x9gknd 12907 20 the the DT cord-010119-t1x9gknd 12907 21 risk risk NN cord-010119-t1x9gknd 12907 22 that that IN cord-010119-t1x9gknd 12907 23 the the DT cord-010119-t1x9gknd 12907 24 transfusion transfusion NN cord-010119-t1x9gknd 12907 25 service service NN cord-010119-t1x9gknd 12907 26 is be VBZ cord-010119-t1x9gknd 12907 27 not not RB cord-010119-t1x9gknd 12907 28 notified notify VBN cord-010119-t1x9gknd 12907 29 of of IN cord-010119-t1x9gknd 12907 30 patients patient NNS cord-010119-t1x9gknd 12907 31 newly newly RB cord-010119-t1x9gknd 12907 32 requiring require VBG cord-010119-t1x9gknd 12907 33 irradiated irradiate VBN cord-010119-t1x9gknd 12907 34 blood blood NN cord-010119-t1x9gknd 12907 35 components component NNS cord-010119-t1x9gknd 12907 36 . . . cord-010119-t1x9gknd 12908 1 Results result NNS cord-010119-t1x9gknd 12908 2 / / SYM cord-010119-t1x9gknd 12908 3 Findings finding NNS cord-010119-t1x9gknd 12908 4 : : : cord-010119-t1x9gknd 12909 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12909 2 blood blood NN cord-010119-t1x9gknd 12909 3 products product NNS cord-010119-t1x9gknd 12909 4 ordering order VBG cord-010119-t1x9gknd 12909 5 system system NN cord-010119-t1x9gknd 12909 6 has have VBZ cord-010119-t1x9gknd 12909 7 been be VBN cord-010119-t1x9gknd 12909 8 redesigned redesign VBN cord-010119-t1x9gknd 12909 9 to to TO cord-010119-t1x9gknd 12909 10 include include VB cord-010119-t1x9gknd 12909 11 3 3 CD cord-010119-t1x9gknd 12909 12 specific specific JJ cord-010119-t1x9gknd 12909 13 queries query NNS cord-010119-t1x9gknd 12909 14 to to TO cord-010119-t1x9gknd 12909 15 identify identify VB cord-010119-t1x9gknd 12909 16 those those DT cord-010119-t1x9gknd 12909 17 patients patient NNS cord-010119-t1x9gknd 12909 18 who who WP cord-010119-t1x9gknd 12909 19 required require VBD cord-010119-t1x9gknd 12909 20 irradiated irradiate VBD cord-010119-t1x9gknd 12909 21 cellular cellular JJ cord-010119-t1x9gknd 12909 22 blood blood NN cord-010119-t1x9gknd 12909 23 products product NNS cord-010119-t1x9gknd 12909 24 . . . cord-010119-t1x9gknd 12910 1 First first RB cord-010119-t1x9gknd 12910 2 , , , cord-010119-t1x9gknd 12910 3 physicians physician NNS cord-010119-t1x9gknd 12910 4 have have VBP cord-010119-t1x9gknd 12910 5 been be VBN cord-010119-t1x9gknd 12910 6 notified notify VBN cord-010119-t1x9gknd 12910 7 to to TO cord-010119-t1x9gknd 12910 8 include include VB cord-010119-t1x9gknd 12910 9 the the DT cord-010119-t1x9gknd 12910 10 need need NN cord-010119-t1x9gknd 12910 11 for for IN cord-010119-t1x9gknd 12910 12 blood blood NN cord-010119-t1x9gknd 12910 13 product product NN cord-010119-t1x9gknd 12910 14 irradiation irradiation NN cord-010119-t1x9gknd 12910 15 in in IN cord-010119-t1x9gknd 12910 16 the the DT cord-010119-t1x9gknd 12910 17 patient patient NN cord-010119-t1x9gknd 12910 18 Problems problem NNS cord-010119-t1x9gknd 12910 19 List List NNP cord-010119-t1x9gknd 12910 20 . . . cord-010119-t1x9gknd 12911 1 Once once RB cord-010119-t1x9gknd 12911 2 this this DT cord-010119-t1x9gknd 12911 3 is be VBZ cord-010119-t1x9gknd 12911 4 included include VBN cord-010119-t1x9gknd 12911 5 in in IN cord-010119-t1x9gknd 12911 6 the the DT cord-010119-t1x9gknd 12911 7 list list NN cord-010119-t1x9gknd 12911 8 , , , cord-010119-t1x9gknd 12911 9 the the DT cord-010119-t1x9gknd 12911 10 transfusion transfusion NN cord-010119-t1x9gknd 12911 11 service service NN cord-010119-t1x9gknd 12911 12 will will MD cord-010119-t1x9gknd 12911 13 be be VB cord-010119-t1x9gknd 12911 14 notified notify VBN cord-010119-t1x9gknd 12911 15 of of IN cord-010119-t1x9gknd 12911 16 the the DT cord-010119-t1x9gknd 12911 17 need need NN cord-010119-t1x9gknd 12911 18 for for IN cord-010119-t1x9gknd 12911 19 irradiation irradiation NN cord-010119-t1x9gknd 12911 20 on on IN cord-010119-t1x9gknd 12911 21 all all DT cord-010119-t1x9gknd 12911 22 subsequent subsequent JJ cord-010119-t1x9gknd 12911 23 transfusion transfusion NN cord-010119-t1x9gknd 12911 24 orders order NNS cord-010119-t1x9gknd 12911 25 until until IN cord-010119-t1x9gknd 12911 26 the the DT cord-010119-t1x9gknd 12911 27 Problem Problem NNP cord-010119-t1x9gknd 12911 28 List List NNP cord-010119-t1x9gknd 12911 29 is be VBZ cord-010119-t1x9gknd 12911 30 modified modify VBN cord-010119-t1x9gknd 12911 31 by by IN cord-010119-t1x9gknd 12911 32 the the DT cord-010119-t1x9gknd 12911 33 clinical clinical JJ cord-010119-t1x9gknd 12911 34 staff staff NN cord-010119-t1x9gknd 12911 35 . . . cord-010119-t1x9gknd 12912 1 Second second RB cord-010119-t1x9gknd 12912 2 , , , cord-010119-t1x9gknd 12912 3 if if IN cord-010119-t1x9gknd 12912 4 irradiated irradiate VBN cord-010119-t1x9gknd 12912 5 blood blood NN cord-010119-t1x9gknd 12912 6 components component NNS cord-010119-t1x9gknd 12912 7 have have VBP cord-010119-t1x9gknd 12912 8 ever ever RB cord-010119-t1x9gknd 12912 9 been be VBN cord-010119-t1x9gknd 12912 10 requested request VBN cord-010119-t1x9gknd 12912 11 on on IN cord-010119-t1x9gknd 12912 12 a a DT cord-010119-t1x9gknd 12912 13 patient patient NN cord-010119-t1x9gknd 12912 14 , , , cord-010119-t1x9gknd 12912 15 an an DT cord-010119-t1x9gknd 12912 16 alert alert NN cord-010119-t1x9gknd 12912 17 will will MD cord-010119-t1x9gknd 12912 18 be be VB cord-010119-t1x9gknd 12912 19 generated generate VBN cord-010119-t1x9gknd 12912 20 for for IN cord-010119-t1x9gknd 12912 21 the the DT cord-010119-t1x9gknd 12912 22 ordering order VBG cord-010119-t1x9gknd 12912 23 physician physician NN cord-010119-t1x9gknd 12912 24 even even RB cord-010119-t1x9gknd 12912 25 if if IN cord-010119-t1x9gknd 12912 26 the the DT cord-010119-t1x9gknd 12912 27 requirement requirement NN cord-010119-t1x9gknd 12912 28 for for IN cord-010119-t1x9gknd 12912 29 irradiated irradiate VBN cord-010119-t1x9gknd 12912 30 products product NNS cord-010119-t1x9gknd 12912 31 has have VBZ cord-010119-t1x9gknd 12912 32 not not RB cord-010119-t1x9gknd 12912 33 been be VBN cord-010119-t1x9gknd 12912 34 included include VBN cord-010119-t1x9gknd 12912 35 in in IN cord-010119-t1x9gknd 12912 36 the the DT cord-010119-t1x9gknd 12912 37 problem problem NN cord-010119-t1x9gknd 12912 38 list list NN cord-010119-t1x9gknd 12912 39 . . . cord-010119-t1x9gknd 12913 1 Finally finally RB cord-010119-t1x9gknd 12913 2 our -PRON- PRP$ cord-010119-t1x9gknd 12913 3 system system NN cord-010119-t1x9gknd 12913 4 will will MD cord-010119-t1x9gknd 12913 5 automatically automatically RB cord-010119-t1x9gknd 12913 6 default default VB cord-010119-t1x9gknd 12913 7 to to TO cord-010119-t1x9gknd 12913 8 request request VB cord-010119-t1x9gknd 12913 9 irradiation irradiation NN cord-010119-t1x9gknd 12913 10 on on IN cord-010119-t1x9gknd 12913 11 all all DT cord-010119-t1x9gknd 12913 12 cellular cellular JJ cord-010119-t1x9gknd 12913 13 products product NNS cord-010119-t1x9gknd 12913 14 ordered order VBN cord-010119-t1x9gknd 12913 15 for for IN cord-010119-t1x9gknd 12913 16 children child NNS cord-010119-t1x9gknd 12913 17 less less JJR cord-010119-t1x9gknd 12913 18 than than IN cord-010119-t1x9gknd 12913 19 4 4 CD cord-010119-t1x9gknd 12913 20 months month NNS cord-010119-t1x9gknd 12913 21 of of IN cord-010119-t1x9gknd 12913 22 age age NN cord-010119-t1x9gknd 12913 23 to to TO cord-010119-t1x9gknd 12913 24 comply comply VB cord-010119-t1x9gknd 12913 25 with with IN cord-010119-t1x9gknd 12913 26 local local JJ cord-010119-t1x9gknd 12913 27 irradiation irradiation NN cord-010119-t1x9gknd 12913 28 policies policy NNS cord-010119-t1x9gknd 12913 29 . . . cord-010119-t1x9gknd 12914 1 Conclusion conclusion NN cord-010119-t1x9gknd 12914 2 : : : cord-010119-t1x9gknd 12915 1 We -PRON- PRP cord-010119-t1x9gknd 12915 2 believe believe VBP cord-010119-t1x9gknd 12915 3 that that IN cord-010119-t1x9gknd 12915 4 our -PRON- PRP$ cord-010119-t1x9gknd 12915 5 approach approach NN cord-010119-t1x9gknd 12915 6 can can MD cord-010119-t1x9gknd 12915 7 be be VB cord-010119-t1x9gknd 12915 8 further further RB cord-010119-t1x9gknd 12915 9 enhanced enhance VBN cord-010119-t1x9gknd 12915 10 by by IN cord-010119-t1x9gknd 12915 11 including include VBG cord-010119-t1x9gknd 12915 12 a a DT cord-010119-t1x9gknd 12915 13 list list NN cord-010119-t1x9gknd 12915 14 of of IN cord-010119-t1x9gknd 12915 15 specific specific JJ cord-010119-t1x9gknd 12915 16 diagnoses diagnosis NNS cord-010119-t1x9gknd 12915 17 typically typically RB cord-010119-t1x9gknd 12915 18 requiring require VBG cord-010119-t1x9gknd 12915 19 blood blood NN cord-010119-t1x9gknd 12915 20 product product NN cord-010119-t1x9gknd 12915 21 irradiation irradiation NN cord-010119-t1x9gknd 12915 22 within within IN cord-010119-t1x9gknd 12915 23 our -PRON- PRP$ cord-010119-t1x9gknd 12915 24 computer computer NN cord-010119-t1x9gknd 12915 25 algorithm algorithm NN cord-010119-t1x9gknd 12915 26 . . . cord-010119-t1x9gknd 12916 1 We -PRON- PRP cord-010119-t1x9gknd 12916 2 believe believe VBP cord-010119-t1x9gknd 12916 3 that that IN cord-010119-t1x9gknd 12916 4 this this DT cord-010119-t1x9gknd 12916 5 list list NN cord-010119-t1x9gknd 12916 6 will will MD cord-010119-t1x9gknd 12916 7 provide provide VB cord-010119-t1x9gknd 12916 8 an an DT cord-010119-t1x9gknd 12916 9 additional additional JJ cord-010119-t1x9gknd 12916 10 level level NN cord-010119-t1x9gknd 12916 11 of of IN cord-010119-t1x9gknd 12916 12 safety safety NN cord-010119-t1x9gknd 12916 13 in in IN cord-010119-t1x9gknd 12916 14 insuring insure VBG cord-010119-t1x9gknd 12916 15 that that IN cord-010119-t1x9gknd 12916 16 patients patient NNS cord-010119-t1x9gknd 12916 17 receive receive VBP cord-010119-t1x9gknd 12916 18 irradiated irradiate VBN cord-010119-t1x9gknd 12916 19 blood blood NN cord-010119-t1x9gknd 12916 20 components component NNS cord-010119-t1x9gknd 12916 21 when when WRB cord-010119-t1x9gknd 12916 22 appropriate appropriate JJ cord-010119-t1x9gknd 12916 23 . . . cord-010119-t1x9gknd 12917 1 Using use VBG cord-010119-t1x9gknd 12917 2 Lab Lab NNP cord-010119-t1x9gknd 12917 3 Information Information NNP cord-010119-t1x9gknd 12917 4 System System NNP cord-010119-t1x9gknd 12917 5 and and CC cord-010119-t1x9gknd 12917 6 a a DT cord-010119-t1x9gknd 12917 7 Dynamic Dynamic NNP cord-010119-t1x9gknd 12917 8 Dashboard dashboard NN cord-010119-t1x9gknd 12917 9 for for IN cord-010119-t1x9gknd 12917 10 Labeling labeling NN cord-010119-t1x9gknd 12917 11 and and CC cord-010119-t1x9gknd 12917 12 Tracking tracking NN cord-010119-t1x9gknd 12917 13 Coolers cooler NNS cord-010119-t1x9gknd 12918 1 Russell Russell NNP cord-010119-t1x9gknd 12918 2 Thorsen Thorsen NNP cord-010119-t1x9gknd 12918 3 , , , cord-010119-t1x9gknd 12918 4 Rosaline Rosaline NNP cord-010119-t1x9gknd 12918 5 Ma Ma NNP cord-010119-t1x9gknd 12918 6 , , , cord-010119-t1x9gknd 12918 7 Peter Peter NNP cord-010119-t1x9gknd 12918 8 Suslow Suslow NNP cord-010119-t1x9gknd 12918 9 , , , cord-010119-t1x9gknd 12918 10 Gina Gina NNP cord-010119-t1x9gknd 12918 11 Giannarelli Giannarelli NNP cord-010119-t1x9gknd 12918 12 , , , cord-010119-t1x9gknd 12918 13 Sara Sara NNP cord-010119-t1x9gknd 12918 14 Bakhtary Bakhtary NNP cord-010119-t1x9gknd 12918 15 , , , cord-010119-t1x9gknd 12918 16 Ashok Ashok NNP cord-010119-t1x9gknd 12918 17 Nambiar Nambiar NNP cord-010119-t1x9gknd 12918 18 and and CC cord-010119-t1x9gknd 12918 19 Morvarid Morvarid NNP cord-010119-t1x9gknd 12918 20 Moayeri Moayeri NNP cord-010119-t1x9gknd 12919 1 * * NFP cord-010119-t1x9gknd 12919 2 . . . cord-010119-t1x9gknd 12920 1 UCSF UCSF NNP cord-010119-t1x9gknd 12920 2 Health Health NNP cord-010119-t1x9gknd 12920 3 Background Background NNP cord-010119-t1x9gknd 12920 4 / / SYM cord-010119-t1x9gknd 12920 5 Case Case NNP cord-010119-t1x9gknd 12920 6 Studies Studies NNPS cord-010119-t1x9gknd 12920 7 : : : cord-010119-t1x9gknd 12920 8 Our -PRON- PRP$ cord-010119-t1x9gknd 12920 9 tertiary tertiary JJ cord-010119-t1x9gknd 12920 10 - - HYPH cord-010119-t1x9gknd 12920 11 care care NN cord-010119-t1x9gknd 12920 12 transfusion transfusion NN cord-010119-t1x9gknd 12920 13 service service NN cord-010119-t1x9gknd 12920 14 routinely routinely RB cord-010119-t1x9gknd 12920 15 issues issue VBZ cord-010119-t1x9gknd 12920 16 blood blood NN cord-010119-t1x9gknd 12920 17 products product NNS cord-010119-t1x9gknd 12920 18 in in IN cord-010119-t1x9gknd 12920 19 validated validate VBN cord-010119-t1x9gknd 12920 20 coolers cooler NNS cord-010119-t1x9gknd 12920 21 to to IN cord-010119-t1x9gknd 12920 22 high high JJ cord-010119-t1x9gknd 12920 23 acuity acuity NN cord-010119-t1x9gknd 12920 24 areas area NNS cord-010119-t1x9gknd 12920 25 such such JJ cord-010119-t1x9gknd 12920 26 as as IN cord-010119-t1x9gknd 12920 27 ORs or NNS cord-010119-t1x9gknd 12920 28 , , , cord-010119-t1x9gknd 12920 29 ICUs ICUs NNP cord-010119-t1x9gknd 12920 30 , , , cord-010119-t1x9gknd 12920 31 Cath Cath NNP cord-010119-t1x9gknd 12920 32 - - HYPH cord-010119-t1x9gknd 12920 33 Lab lab NN cord-010119-t1x9gknd 12920 34 , , , cord-010119-t1x9gknd 12920 35 etc etc FW cord-010119-t1x9gknd 12920 36 . . . cord-010119-t1x9gknd 12921 1 Coolers cooler NNS cord-010119-t1x9gknd 12921 2 are be VBP cord-010119-t1x9gknd 12921 3 also also RB cord-010119-t1x9gknd 12921 4 used use VBN cord-010119-t1x9gknd 12921 5 for for IN cord-010119-t1x9gknd 12921 6 emergency emergency NN cord-010119-t1x9gknd 12921 7 release release NN cord-010119-t1x9gknd 12921 8 and and CC cord-010119-t1x9gknd 12921 9 massive massive JJ cord-010119-t1x9gknd 12921 10 transfusion transfusion NN cord-010119-t1x9gknd 12921 11 protocols protocol NNS cord-010119-t1x9gknd 12921 12 , , , cord-010119-t1x9gknd 12921 13 and and CC cord-010119-t1x9gknd 12921 14 for for IN cord-010119-t1x9gknd 12921 15 shipping shipping NN cord-010119-t1x9gknd 12921 16 products product NNS cord-010119-t1x9gknd 12921 17 between between IN cord-010119-t1x9gknd 12921 18 our -PRON- PRP$ cord-010119-t1x9gknd 12921 19 different different JJ cord-010119-t1x9gknd 12921 20 hospital hospital NN cord-010119-t1x9gknd 12921 21 sites site NNS cord-010119-t1x9gknd 12921 22 . . . cord-010119-t1x9gknd 12922 1 A a DT cord-010119-t1x9gknd 12922 2 robot robot NN cord-010119-t1x9gknd 12922 3 that that WDT cord-010119-t1x9gknd 12922 4 can can MD cord-010119-t1x9gknd 12922 5 hold hold VB cord-010119-t1x9gknd 12922 6 one one CD cord-010119-t1x9gknd 12922 7 cooler cooler NN cord-010119-t1x9gknd 12922 8 delivers deliver VBZ cord-010119-t1x9gknd 12922 9 products product NNS cord-010119-t1x9gknd 12922 10 to to IN cord-010119-t1x9gknd 12922 11 locations location NNS cord-010119-t1x9gknd 12922 12 not not RB cord-010119-t1x9gknd 12922 13 served serve VBN cord-010119-t1x9gknd 12922 14 by by IN cord-010119-t1x9gknd 12922 15 the the DT cord-010119-t1x9gknd 12922 16 pneumatic pneumatic JJ cord-010119-t1x9gknd 12922 17 tube tube NN cord-010119-t1x9gknd 12922 18 . . . cord-010119-t1x9gknd 12923 1 On on IN cord-010119-t1x9gknd 12923 2 average average JJ cord-010119-t1x9gknd 12923 3 , , , cord-010119-t1x9gknd 12923 4 30 30 CD cord-010119-t1x9gknd 12923 5 coolers cooler NNS cord-010119-t1x9gknd 12923 6 are be VBP cord-010119-t1x9gknd 12923 7 issued issue VBN cord-010119-t1x9gknd 12923 8 every every DT cord-010119-t1x9gknd 12923 9 day day NN cord-010119-t1x9gknd 12923 10 . . . cord-010119-t1x9gknd 12924 1 Cooler cool JJR cord-010119-t1x9gknd 12924 2 set set NN cord-010119-t1x9gknd 12924 3 - - HYPH cord-010119-t1x9gknd 12924 4 up up NN cord-010119-t1x9gknd 12924 5 is be VBZ cord-010119-t1x9gknd 12924 6 a a DT cord-010119-t1x9gknd 12924 7 multi multi JJ cord-010119-t1x9gknd 12924 8 - - JJ cord-010119-t1x9gknd 12924 9 step step JJ cord-010119-t1x9gknd 12924 10 , , , cord-010119-t1x9gknd 12924 11 labor labor NN cord-010119-t1x9gknd 12924 12 - - HYPH cord-010119-t1x9gknd 12924 13 intensive intensive JJ cord-010119-t1x9gknd 12924 14 process process NN cord-010119-t1x9gknd 12924 15 . . . cord-010119-t1x9gknd 12925 1 Transfusion Transfusion NNP cord-010119-t1x9gknd 12925 2 Service Service NNP cord-010119-t1x9gknd 12925 3 staff staff NN cord-010119-t1x9gknd 12925 4 track track NN cord-010119-t1x9gknd 12925 5 cooler cool JJR cord-010119-t1x9gknd 12925 6 location location NN cord-010119-t1x9gknd 12925 7 and and CC cord-010119-t1x9gknd 12925 8 elapsed elapsed JJ cord-010119-t1x9gknd 12925 9 time time NN cord-010119-t1x9gknd 12925 10 - - HYPH cord-010119-t1x9gknd 12925 11 in in IN cord-010119-t1x9gknd 12925 12 - - HYPH cord-010119-t1x9gknd 12925 13 use use NN cord-010119-t1x9gknd 12925 14 and and CC cord-010119-t1x9gknd 12925 15 notify notify VB cord-010119-t1x9gknd 12925 16 clinical clinical JJ cord-010119-t1x9gknd 12925 17 teams team NNS cord-010119-t1x9gknd 12925 18 to to TO cord-010119-t1x9gknd 12925 19 return return VB cord-010119-t1x9gknd 12925 20 / / SYM cord-010119-t1x9gknd 12925 21 recharge recharge VB cord-010119-t1x9gknd 12925 22 coolers cooler NNS cord-010119-t1x9gknd 12925 23 to to TO cord-010119-t1x9gknd 12925 24 avoid avoid VB cord-010119-t1x9gknd 12925 25 product product NN cord-010119-t1x9gknd 12925 26 wastage wastage NN cord-010119-t1x9gknd 12925 27 . . . cord-010119-t1x9gknd 12926 1 We -PRON- PRP cord-010119-t1x9gknd 12926 2 developed develop VBD cord-010119-t1x9gknd 12926 3 a a DT cord-010119-t1x9gknd 12926 4 lab lab NN cord-010119-t1x9gknd 12926 5 information information NN cord-010119-t1x9gknd 12926 6 system system NN cord-010119-t1x9gknd 12926 7 ( ( -LRB- cord-010119-t1x9gknd 12926 8 LIS)-based lis)-based JJ cord-010119-t1x9gknd 12926 9 solution solution NN cord-010119-t1x9gknd 12926 10 to to TO cord-010119-t1x9gknd 12926 11 manage manage VB cord-010119-t1x9gknd 12926 12 cooler cool JJR cord-010119-t1x9gknd 12926 13 labelling labelling NN cord-010119-t1x9gknd 12926 14 and and CC cord-010119-t1x9gknd 12926 15 tracking track VBG cord-010119-t1x9gknd 12926 16 more more RBR cord-010119-t1x9gknd 12926 17 efficiently efficiently RB cord-010119-t1x9gknd 12926 18 . . . cord-010119-t1x9gknd 12927 1 Study Study NNP cord-010119-t1x9gknd 12927 2 Design Design NNP cord-010119-t1x9gknd 12927 3 / / SYM cord-010119-t1x9gknd 12927 4 Method method NN cord-010119-t1x9gknd 12927 5 : : : cord-010119-t1x9gknd 12928 1 Nine nine CD cord-010119-t1x9gknd 12928 2 cooler cool JJR cord-010119-t1x9gknd 12928 3 test test NN cord-010119-t1x9gknd 12928 4 batteries battery NNS cord-010119-t1x9gknd 12928 5 were be VBD cord-010119-t1x9gknd 12928 6 built build VBN cord-010119-t1x9gknd 12928 7 ; ; : cord-010119-t1x9gknd 12928 8 the the DT cord-010119-t1x9gknd 12928 9 batteries battery NNS cord-010119-t1x9gknd 12928 10 for for IN cord-010119-t1x9gknd 12928 11 RBC RBC NNP cord-010119-t1x9gknd 12928 12 , , , cord-010119-t1x9gknd 12928 13 plasma plasma NN cord-010119-t1x9gknd 12928 14 , , , cord-010119-t1x9gknd 12928 15 platelet platelet NN cord-010119-t1x9gknd 12928 16 and and CC cord-010119-t1x9gknd 12928 17 cryoprecipitate cryoprecipitate NNP cord-010119-t1x9gknd 12928 18 ( ( -LRB- cord-010119-t1x9gknd 12928 19 2 2 CD cord-010119-t1x9gknd 12928 20 each each DT cord-010119-t1x9gknd 12928 21 ) ) -RRB- cord-010119-t1x9gknd 12928 22 are be VBP cord-010119-t1x9gknd 12928 23 identical identical JJ cord-010119-t1x9gknd 12928 24 , , , cord-010119-t1x9gknd 12928 25 whereas whereas IN cord-010119-t1x9gknd 12928 26 the the DT cord-010119-t1x9gknd 12928 27 final final JJ cord-010119-t1x9gknd 12928 28 battery battery NN cord-010119-t1x9gknd 12928 29 designated designate VBN cord-010119-t1x9gknd 12928 30 for for IN cord-010119-t1x9gknd 12928 31 the the DT cord-010119-t1x9gknd 12928 32 cooler cooler NN cord-010119-t1x9gknd 12928 33 delivered deliver VBN cord-010119-t1x9gknd 12928 34 by by IN cord-010119-t1x9gknd 12928 35 robot robot NN cord-010119-t1x9gknd 12928 36 ( ( -LRB- cord-010119-t1x9gknd 12928 37 containing contain VBG cord-010119-t1x9gknd 12928 38 plasma plasma NN cord-010119-t1x9gknd 12928 39 and and CC cord-010119-t1x9gknd 12928 40 RBCs rbc NNS cord-010119-t1x9gknd 12928 41 with with IN cord-010119-t1x9gknd 12928 42 variable variable JJ cord-010119-t1x9gknd 12928 43 expiration expiration NN cord-010119-t1x9gknd 12928 44 times time NNS cord-010119-t1x9gknd 12928 45 ) ) -RRB- cord-010119-t1x9gknd 12928 46 is be VBZ cord-010119-t1x9gknd 12928 47 slightly slightly RB cord-010119-t1x9gknd 12928 48 different different JJ cord-010119-t1x9gknd 12928 49 . . . cord-010119-t1x9gknd 12929 1 The the DT cord-010119-t1x9gknd 12929 2 second second JJ cord-010119-t1x9gknd 12929 3 battery battery NN cord-010119-t1x9gknd 12929 4 in in IN cord-010119-t1x9gknd 12929 5 each each DT cord-010119-t1x9gknd 12929 6 pair pair NN cord-010119-t1x9gknd 12929 7 was be VBD cord-010119-t1x9gknd 12929 8 built build VBN cord-010119-t1x9gknd 12929 9 to to TO cord-010119-t1x9gknd 12929 10 avoid avoid VB cord-010119-t1x9gknd 12929 11 duplicate duplicate JJ cord-010119-t1x9gknd 12929 12 test test NN cord-010119-t1x9gknd 12929 13 cancellation cancellation NN cord-010119-t1x9gknd 12929 14 by by IN cord-010119-t1x9gknd 12929 15 LIS LIS NNP cord-010119-t1x9gknd 12929 16 when when WRB cord-010119-t1x9gknd 12929 17 a a DT cord-010119-t1x9gknd 12929 18 second second JJ cord-010119-t1x9gknd 12929 19 cooler cooler NN cord-010119-t1x9gknd 12929 20 ( ( -LRB- cord-010119-t1x9gknd 12929 21 for for IN cord-010119-t1x9gknd 12929 22 same same JJ cord-010119-t1x9gknd 12929 23 component component NN cord-010119-t1x9gknd 12929 24 type type NN cord-010119-t1x9gknd 12929 25 ) ) -RRB- cord-010119-t1x9gknd 12929 26 is be VBZ cord-010119-t1x9gknd 12929 27 being be VBG cord-010119-t1x9gknd 12929 28 set set VBN cord-010119-t1x9gknd 12929 29 up up RP cord-010119-t1x9gknd 12929 30 for for IN cord-010119-t1x9gknd 12929 31 the the DT cord-010119-t1x9gknd 12929 32 same same JJ cord-010119-t1x9gknd 12929 33 patient patient NN cord-010119-t1x9gknd 12929 34 . . . cord-010119-t1x9gknd 12930 1 Each each DT cord-010119-t1x9gknd 12930 2 battery battery NN cord-010119-t1x9gknd 12930 3 consists consist VBZ cord-010119-t1x9gknd 12930 4 of of IN cord-010119-t1x9gknd 12930 5 tests test NNS cord-010119-t1x9gknd 12930 6 capturing capture VBG cord-010119-t1x9gknd 12930 7 the the DT cord-010119-t1x9gknd 12930 8 following follow VBG cord-010119-t1x9gknd 12930 9 information information NN cord-010119-t1x9gknd 12930 10 : : : cord-010119-t1x9gknd 12930 11 cooler cool JJR cord-010119-t1x9gknd 12930 12 location location NN cord-010119-t1x9gknd 12930 13 , , , cord-010119-t1x9gknd 12930 14 cooler cool JJR cord-010119-t1x9gknd 12930 15 ID ID NNP cord-010119-t1x9gknd 12930 16 , , , cord-010119-t1x9gknd 12930 17 number number NN cord-010119-t1x9gknd 12930 18 of of IN cord-010119-t1x9gknd 12930 19 units unit NNS cord-010119-t1x9gknd 12930 20 issued issue VBN cord-010119-t1x9gknd 12930 21 , , , cord-010119-t1x9gknd 12930 22 and and CC cord-010119-t1x9gknd 12930 23 expiration expiration NN cord-010119-t1x9gknd 12930 24 . . . cord-010119-t1x9gknd 12931 1 Custom custom NN cord-010119-t1x9gknd 12931 2 barcodes barcode NNS cord-010119-t1x9gknd 12931 3 representing represent VBG cord-010119-t1x9gknd 12931 4 each each DT cord-010119-t1x9gknd 12931 5 test test NN cord-010119-t1x9gknd 12931 6 battery battery NN cord-010119-t1x9gknd 12931 7 and and CC cord-010119-t1x9gknd 12931 8 45 45 CD cord-010119-t1x9gknd 12931 9 different different JJ cord-010119-t1x9gknd 12931 10 locations location NNS cord-010119-t1x9gknd 12931 11 can can MD cord-010119-t1x9gknd 12931 12 be be VB cord-010119-t1x9gknd 12931 13 scanned scan VBN cord-010119-t1x9gknd 12931 14 from from IN cord-010119-t1x9gknd 12931 15 a a DT cord-010119-t1x9gknd 12931 16 ' ' `` cord-010119-t1x9gknd 12931 17 quick quick JJ cord-010119-t1x9gknd 12931 18 - - HYPH cord-010119-t1x9gknd 12931 19 pick pick NN cord-010119-t1x9gknd 12931 20 list list NN cord-010119-t1x9gknd 12931 21 ' ' '' cord-010119-t1x9gknd 12931 22 , , , cord-010119-t1x9gknd 12931 23 avoiding avoid VBG cord-010119-t1x9gknd 12931 24 need need NN cord-010119-t1x9gknd 12931 25 for for IN cord-010119-t1x9gknd 12931 26 manual manual JJ cord-010119-t1x9gknd 12931 27 entry entry NN cord-010119-t1x9gknd 12931 28 . . . cord-010119-t1x9gknd 12932 1 When when WRB cord-010119-t1x9gknd 12932 2 coolers cooler NNS cord-010119-t1x9gknd 12932 3 are be VBP cord-010119-t1x9gknd 12932 4 returned return VBN cord-010119-t1x9gknd 12932 5 , , , cord-010119-t1x9gknd 12932 6 a a DT cord-010119-t1x9gknd 12932 7 final final JJ cord-010119-t1x9gknd 12932 8 entry entry NN cord-010119-t1x9gknd 12932 9 is be VBZ cord-010119-t1x9gknd 12932 10 made make VBN cord-010119-t1x9gknd 12932 11 in in IN cord-010119-t1x9gknd 12932 12 the the DT cord-010119-t1x9gknd 12932 13 test test NN cord-010119-t1x9gknd 12932 14 battery battery NN cord-010119-t1x9gknd 12932 15 , , , cord-010119-t1x9gknd 12932 16 updating update VBG cord-010119-t1x9gknd 12932 17 LIS LIS NNP cord-010119-t1x9gknd 12932 18 . . . cord-010119-t1x9gknd 12933 1 A a DT cord-010119-t1x9gknd 12933 2 dynamic dynamic JJ cord-010119-t1x9gknd 12933 3 cooler cooler NN cord-010119-t1x9gknd 12933 4 tracking tracking NN cord-010119-t1x9gknd 12933 5 dashboard dashboard NN cord-010119-t1x9gknd 12933 6 with with IN cord-010119-t1x9gknd 12933 7 live live JJ cord-010119-t1x9gknd 12933 8 - - HYPH cord-010119-t1x9gknd 12933 9 feed feed NN cord-010119-t1x9gknd 12933 10 from from IN cord-010119-t1x9gknd 12933 11 LIS LIS NNP cord-010119-t1x9gknd 12933 12 displays display NNS cord-010119-t1x9gknd 12933 13 data datum NNS cord-010119-t1x9gknd 12933 14 captured capture VBN cord-010119-t1x9gknd 12933 15 in in IN cord-010119-t1x9gknd 12933 16 the the DT cord-010119-t1x9gknd 12933 17 test test NN cord-010119-t1x9gknd 12933 18 battery battery NN cord-010119-t1x9gknd 12933 19 . . . cord-010119-t1x9gknd 12934 1 Elapsed elapsed JJ cord-010119-t1x9gknd 12934 2 time time NN cord-010119-t1x9gknd 12934 3 , , , cord-010119-t1x9gknd 12934 4 starting start VBG cord-010119-t1x9gknd 12934 5 from from IN cord-010119-t1x9gknd 12934 6 cooler cool JJR cord-010119-t1x9gknd 12934 7 set set NN cord-010119-t1x9gknd 12934 8 - - HYPH cord-010119-t1x9gknd 12934 9 up up NN cord-010119-t1x9gknd 12934 10 ( ( -LRB- cord-010119-t1x9gknd 12934 11 which which WDT cord-010119-t1x9gknd 12934 12 is be VBZ cord-010119-t1x9gknd 12934 13 identical identical JJ cord-010119-t1x9gknd 12934 14 to to IN cord-010119-t1x9gknd 12934 15 time time NN cord-010119-t1x9gknd 12934 16 cooler cool JJR cord-010119-t1x9gknd 12934 17 battery battery NN cord-010119-t1x9gknd 12934 18 is be VBZ cord-010119-t1x9gknd 12934 19 ordered order VBN cord-010119-t1x9gknd 12934 20 in in IN cord-010119-t1x9gknd 12934 21 LIS LIS NNP cord-010119-t1x9gknd 12934 22 ) ) -RRB- cord-010119-t1x9gknd 12934 23 is be VBZ cord-010119-t1x9gknd 12934 24 captured capture VBN cord-010119-t1x9gknd 12934 25 automatically automatically RB cord-010119-t1x9gknd 12934 26 . . . cord-010119-t1x9gknd 12935 1 Color color NN cord-010119-t1x9gknd 12935 2 codes code NNS cord-010119-t1x9gknd 12935 3 alert alert VBP cord-010119-t1x9gknd 12935 4 users user NNS cord-010119-t1x9gknd 12935 5 to to IN cord-010119-t1x9gknd 12935 6 coolers cooler NNS cord-010119-t1x9gknd 12935 7 that that WDT cord-010119-t1x9gknd 12935 8 have have VBP cord-010119-t1x9gknd 12935 9 less less JJR cord-010119-t1x9gknd 12935 10 than than IN cord-010119-t1x9gknd 12935 11 1 1 CD cord-010119-t1x9gknd 12935 12 hour hour NN cord-010119-t1x9gknd 12935 13 before before IN cord-010119-t1x9gknd 12935 14 expiration expiration NN cord-010119-t1x9gknd 12935 15 . . . cord-010119-t1x9gknd 12936 1 A a DT cord-010119-t1x9gknd 12936 2 flashing flash VBG cord-010119-t1x9gknd 12936 3 alert alert NN cord-010119-t1x9gknd 12936 4 pops pop VBZ cord-010119-t1x9gknd 12936 5 up up RP cord-010119-t1x9gknd 12936 6 for for IN cord-010119-t1x9gknd 12936 7 coolers cooler NNS cord-010119-t1x9gknd 12936 8 that that WDT cord-010119-t1x9gknd 12936 9 have have VBP cord-010119-t1x9gknd 12936 10 expired expire VBN cord-010119-t1x9gknd 12936 11 . . . cord-010119-t1x9gknd 12937 1 Results result NNS cord-010119-t1x9gknd 12937 2 / / SYM cord-010119-t1x9gknd 12937 3 Finding finding NN cord-010119-t1x9gknd 12937 4 : : : cord-010119-t1x9gknd 12937 5 We -PRON- PRP cord-010119-t1x9gknd 12937 6 replaced replace VBD cord-010119-t1x9gknd 12937 7 our -PRON- PRP$ cord-010119-t1x9gknd 12937 8 manual manual JJ cord-010119-t1x9gknd 12937 9 process process NN cord-010119-t1x9gknd 12937 10 ( ( -LRB- cord-010119-t1x9gknd 12937 11 hand hand NN cord-010119-t1x9gknd 12937 12 - - HYPH cord-010119-t1x9gknd 12937 13 write write NN cord-010119-t1x9gknd 12937 14 patient patient JJ cord-010119-t1x9gknd 12937 15 information information NN cord-010119-t1x9gknd 12937 16 and and CC cord-010119-t1x9gknd 12937 17 expiration expiration NN cord-010119-t1x9gknd 12937 18 time time NN cord-010119-t1x9gknd 12937 19 on on IN cord-010119-t1x9gknd 12937 20 2 2 CD cord-010119-t1x9gknd 12937 21 separate separate JJ cord-010119-t1x9gknd 12937 22 tags tag NNS cord-010119-t1x9gknd 12937 23 ; ; : cord-010119-t1x9gknd 12937 24 affix affix VB cord-010119-t1x9gknd 12937 25 one one CD cord-010119-t1x9gknd 12937 26 tag tag NN cord-010119-t1x9gknd 12937 27 to to TO cord-010119-t1x9gknd 12937 28 cooler cooler VB cord-010119-t1x9gknd 12937 29 and and CC cord-010119-t1x9gknd 12937 30 retain retain VB cord-010119-t1x9gknd 12937 31 second second JJ cord-010119-t1x9gknd 12937 32 one one NN cord-010119-t1x9gknd 12937 33 to to TO cord-010119-t1x9gknd 12937 34 track track VB cord-010119-t1x9gknd 12937 35 cooler cool JJR cord-010119-t1x9gknd 12937 36 location location NN cord-010119-t1x9gknd 12937 37 and and CC cord-010119-t1x9gknd 12937 38 expiration expiration NN cord-010119-t1x9gknd 12937 39 ) ) -RRB- cord-010119-t1x9gknd 12937 40 with with IN cord-010119-t1x9gknd 12937 41 a a DT cord-010119-t1x9gknd 12937 42 novel novel JJ cord-010119-t1x9gknd 12937 43 LIS lis NN cord-010119-t1x9gknd 12937 44 - - HYPH cord-010119-t1x9gknd 12937 45 driven drive VBN cord-010119-t1x9gknd 12937 46 labeling labeling NN cord-010119-t1x9gknd 12937 47 and and CC cord-010119-t1x9gknd 12937 48 tracking tracking NN cord-010119-t1x9gknd 12937 49 system system NN cord-010119-t1x9gknd 12937 50 . . . cord-010119-t1x9gknd 12938 1 Each each DT cord-010119-t1x9gknd 12938 2 time time NN cord-010119-t1x9gknd 12938 3 a a DT cord-010119-t1x9gknd 12938 4 cooler cooler NN cord-010119-t1x9gknd 12938 5 is be VBZ cord-010119-t1x9gknd 12938 6 set set VBN cord-010119-t1x9gknd 12938 7 up up RP cord-010119-t1x9gknd 12938 8 , , , cord-010119-t1x9gknd 12938 9 a a DT cord-010119-t1x9gknd 12938 10 test test NN cord-010119-t1x9gknd 12938 11 battery battery NN cord-010119-t1x9gknd 12938 12 is be VBZ cord-010119-t1x9gknd 12938 13 ordered order VBN cord-010119-t1x9gknd 12938 14 and and CC cord-010119-t1x9gknd 12938 15 resulted result VBN cord-010119-t1x9gknd 12938 16 in in IN cord-010119-t1x9gknd 12938 17 LIS LIS NNP cord-010119-t1x9gknd 12938 18 by by IN cord-010119-t1x9gknd 12938 19 scanning scan VBG cord-010119-t1x9gknd 12938 20 the the DT cord-010119-t1x9gknd 12938 21 related related JJ cord-010119-t1x9gknd 12938 22 custom custom NN cord-010119-t1x9gknd 12938 23 barcodes barcode NNS cord-010119-t1x9gknd 12938 24 . . . cord-010119-t1x9gknd 12939 1 A a DT cord-010119-t1x9gknd 12939 2 single single JJ cord-010119-t1x9gknd 12939 3 LIS lis NN cord-010119-t1x9gknd 12939 4 - - HYPH cord-010119-t1x9gknd 12939 5 generated generate VBN cord-010119-t1x9gknd 12939 6 label label NN cord-010119-t1x9gknd 12939 7 is be VBZ cord-010119-t1x9gknd 12939 8 printed print VBN cord-010119-t1x9gknd 12939 9 and and CC cord-010119-t1x9gknd 12939 10 attached attach VBN cord-010119-t1x9gknd 12939 11 to to IN cord-010119-t1x9gknd 12939 12 each each DT cord-010119-t1x9gknd 12939 13 cooler cool JJR cord-010119-t1x9gknd 12939 14 . . . cord-010119-t1x9gknd 12940 1 Cooler cool JJR cord-010119-t1x9gknd 12940 2 expiration expiration NN cord-010119-t1x9gknd 12940 3 is be VBZ cord-010119-t1x9gknd 12940 4 defaulted default VBN cord-010119-t1x9gknd 12940 5 to to IN cord-010119-t1x9gknd 12940 6 10 10 CD cord-010119-t1x9gknd 12940 7 hours hour NNS cord-010119-t1x9gknd 12940 8 ( ( -LRB- cord-010119-t1x9gknd 12940 9 per per IN cord-010119-t1x9gknd 12940 10 our -PRON- PRP$ cord-010119-t1x9gknd 12940 11 current current JJ cord-010119-t1x9gknd 12940 12 cooler cool JJR cord-010119-t1x9gknd 12940 13 validation validation NN cord-010119-t1x9gknd 12940 14 ) ) -RRB- cord-010119-t1x9gknd 12940 15 from from IN cord-010119-t1x9gknd 12940 16 the the DT cord-010119-t1x9gknd 12940 17 time time NN cord-010119-t1x9gknd 12940 18 the the DT cord-010119-t1x9gknd 12940 19 test test NN cord-010119-t1x9gknd 12940 20 battery battery NN cord-010119-t1x9gknd 12940 21 is be VBZ cord-010119-t1x9gknd 12940 22 ordered order VBN cord-010119-t1x9gknd 12940 23 during during IN cord-010119-t1x9gknd 12940 24 cooler cooler RBR cord-010119-t1x9gknd 12940 25 set set VBN cord-010119-t1x9gknd 12940 26 up up RP cord-010119-t1x9gknd 12940 27 . . . cord-010119-t1x9gknd 12941 1 Techs tech NNS cord-010119-t1x9gknd 12941 2 pay pay VBP cord-010119-t1x9gknd 12941 3 attention attention NN cord-010119-t1x9gknd 12941 4 to to IN cord-010119-t1x9gknd 12941 5 expiration expiration NN cord-010119-t1x9gknd 12941 6 of of IN cord-010119-t1x9gknd 12941 7 each each DT cord-010119-t1x9gknd 12941 8 product product NN cord-010119-t1x9gknd 12941 9 they -PRON- PRP cord-010119-t1x9gknd 12941 10 place place VBP cord-010119-t1x9gknd 12941 11 in in IN cord-010119-t1x9gknd 12941 12 a a DT cord-010119-t1x9gknd 12941 13 cooler cooler NN cord-010119-t1x9gknd 12941 14 . . . cord-010119-t1x9gknd 12942 1 If if IN cord-010119-t1x9gknd 12942 2 an an DT cord-010119-t1x9gknd 12942 3 individual individual JJ cord-010119-t1x9gknd 12942 4 product product NN cord-010119-t1x9gknd 12942 5 outdates outdate VBZ cord-010119-t1x9gknd 12942 6 before before IN cord-010119-t1x9gknd 12942 7 the the DT cord-010119-t1x9gknd 12942 8 cooler cool JJR cord-010119-t1x9gknd 12942 9 expiration expiration NN cord-010119-t1x9gknd 12942 10 time time NN cord-010119-t1x9gknd 12942 11 , , , cord-010119-t1x9gknd 12942 12 this this DT cord-010119-t1x9gknd 12942 13 information information NN cord-010119-t1x9gknd 12942 14 is be VBZ cord-010119-t1x9gknd 12942 15 entered enter VBN cord-010119-t1x9gknd 12942 16 in in IN cord-010119-t1x9gknd 12942 17 the the DT cord-010119-t1x9gknd 12942 18 test test NN cord-010119-t1x9gknd 12942 19 battery battery NN cord-010119-t1x9gknd 12942 20 and and CC cord-010119-t1x9gknd 12942 21 gets get VBZ cord-010119-t1x9gknd 12942 22 displayed display VBN cord-010119-t1x9gknd 12942 23 on on IN cord-010119-t1x9gknd 12942 24 the the DT cord-010119-t1x9gknd 12942 25 dashboard dashboard NN cord-010119-t1x9gknd 12942 26 as as IN cord-010119-t1x9gknd 12942 27 a a DT cord-010119-t1x9gknd 12942 28 cooler cool JJR cord-010119-t1x9gknd 12942 29 expiration expiration NN cord-010119-t1x9gknd 12942 30 time time NN cord-010119-t1x9gknd 12942 31 , , , cord-010119-t1x9gknd 12942 32 distinct distinct JJ cord-010119-t1x9gknd 12942 33 from from IN cord-010119-t1x9gknd 12942 34 the the DT cord-010119-t1x9gknd 12942 35 system system NN cord-010119-t1x9gknd 12942 36 - - HYPH cord-010119-t1x9gknd 12942 37 driven drive VBN cord-010119-t1x9gknd 12942 38 countdown countdown NN cord-010119-t1x9gknd 12942 39 . . . cord-010119-t1x9gknd 12943 1 Color color NN cord-010119-t1x9gknd 12943 2 - - HYPH cord-010119-t1x9gknd 12943 3 coded code VBN cord-010119-t1x9gknd 12943 4 visual visual JJ cord-010119-t1x9gknd 12943 5 display display NN cord-010119-t1x9gknd 12943 6 and and CC cord-010119-t1x9gknd 12943 7 alerts alert NNS cord-010119-t1x9gknd 12943 8 greatly greatly RB cord-010119-t1x9gknd 12943 9 simplify simplify VBP cord-010119-t1x9gknd 12943 10 cooler cooler NN cord-010119-t1x9gknd 12943 11 monitoring monitoring NN cord-010119-t1x9gknd 12943 12 , , , cord-010119-t1x9gknd 12943 13 and and CC cord-010119-t1x9gknd 12943 14 the the DT cord-010119-t1x9gknd 12943 15 elimination elimination NN cord-010119-t1x9gknd 12943 16 of of IN cord-010119-t1x9gknd 12943 17 some some DT cord-010119-t1x9gknd 12943 18 manual manual JJ cord-010119-t1x9gknd 12943 19 steps step NNS cord-010119-t1x9gknd 12943 20 has have VBZ cord-010119-t1x9gknd 12943 21 improved improve VBN cord-010119-t1x9gknd 12943 22 staff staff NN cord-010119-t1x9gknd 12943 23 satisfaction satisfaction NN cord-010119-t1x9gknd 12943 24 . . . cord-010119-t1x9gknd 12944 1 Conclusion conclusion NN cord-010119-t1x9gknd 12944 2 : : : cord-010119-t1x9gknd 12944 3 Using use VBG cord-010119-t1x9gknd 12944 4 LIS LIS NNP cord-010119-t1x9gknd 12944 5 for for IN cord-010119-t1x9gknd 12944 6 cooler cool JJR cord-010119-t1x9gknd 12944 7 set set NN cord-010119-t1x9gknd 12944 8 - - HYPH cord-010119-t1x9gknd 12944 9 up up NN cord-010119-t1x9gknd 12944 10 and and CC cord-010119-t1x9gknd 12944 11 deploying deploy VBG cord-010119-t1x9gknd 12944 12 a a DT cord-010119-t1x9gknd 12944 13 linked link VBN cord-010119-t1x9gknd 12944 14 dynamic dynamic JJ cord-010119-t1x9gknd 12944 15 dashboard dashboard NN cord-010119-t1x9gknd 12944 16 to to TO cord-010119-t1x9gknd 12944 17 display display VB cord-010119-t1x9gknd 12944 18 cooler cooler NN cord-010119-t1x9gknd 12944 19 locations location NNS cord-010119-t1x9gknd 12944 20 and and CC cord-010119-t1x9gknd 12944 21 expiration expiration NN cord-010119-t1x9gknd 12944 22 time time NN cord-010119-t1x9gknd 12944 23 makes make VBZ cord-010119-t1x9gknd 12944 24 cooler cool JJR cord-010119-t1x9gknd 12944 25 management management NN cord-010119-t1x9gknd 12944 26 more more RBR cord-010119-t1x9gknd 12944 27 efficient efficient JJ cord-010119-t1x9gknd 12944 28 . . . cord-010119-t1x9gknd 12945 1 These these DT cord-010119-t1x9gknd 12945 2 tools tool NNS cord-010119-t1x9gknd 12945 3 reduce reduce VBP cord-010119-t1x9gknd 12945 4 manual manual JJ cord-010119-t1x9gknd 12945 5 steps step NNS cord-010119-t1x9gknd 12945 6 and and CC cord-010119-t1x9gknd 12945 7 decrease decrease VB cord-010119-t1x9gknd 12945 8 likelihood likelihood NN cord-010119-t1x9gknd 12945 9 of of IN cord-010119-t1x9gknd 12945 10 wastage wastage NN cord-010119-t1x9gknd 12945 11 by by IN cord-010119-t1x9gknd 12945 12 aiding aid VBG cord-010119-t1x9gknd 12945 13 cooler cooler JJ cord-010119-t1x9gknd 12945 14 tracking tracking NN cord-010119-t1x9gknd 12945 15 . . . cord-010119-t1x9gknd 12945 16 _SP cord-010119-t1x9gknd 12946 1 Improving improve VBG cord-010119-t1x9gknd 12946 2 Cryoprecipitate Cryoprecipitate NNP cord-010119-t1x9gknd 12946 3 Collection Collection NNP cord-010119-t1x9gknd 12946 4 Operations Operations NNPS cord-010119-t1x9gknd 12946 5 Using Using NNP cord-010119-t1x9gknd 12946 6 Operations Operations NNPS cord-010119-t1x9gknd 12946 7 Research Research NNP cord-010119-t1x9gknd 12946 8 and and CC cord-010119-t1x9gknd 12946 9 Analytics Analytics NNP cord-010119-t1x9gknd 12946 10 - - HYPH cord-010119-t1x9gknd 12946 11 Based base VBN cord-010119-t1x9gknd 12946 12 Methods Methods NNP cord-010119-t1x9gknd 12946 13 American American NNP cord-010119-t1x9gknd 12946 14 Red Red NNP cord-010119-t1x9gknd 12946 15 Cross Cross NNP cord-010119-t1x9gknd 12946 16 , , , cord-010119-t1x9gknd 12946 17 2 2 CD cord-010119-t1x9gknd 12946 18 Georgia Georgia NNP cord-010119-t1x9gknd 12946 19 Institute Institute NNP cord-010119-t1x9gknd 12946 20 of of IN cord-010119-t1x9gknd 12946 21 Technology Technology NNP cord-010119-t1x9gknd 12946 22 AP72 AP72 NNP cord-010119-t1x9gknd 12946 23 Reduction Reduction NNP cord-010119-t1x9gknd 12946 24 in in IN cord-010119-t1x9gknd 12946 25 Unnecessary unnecessary JJ cord-010119-t1x9gknd 12946 26 Use use NN cord-010119-t1x9gknd 12946 27 of of IN cord-010119-t1x9gknd 12946 28 Type type NN cord-010119-t1x9gknd 12946 29 O o NN cord-010119-t1x9gknd 12946 30 - - HYPH cord-010119-t1x9gknd 12946 31 Negative negative JJ cord-010119-t1x9gknd 12946 32 RBCs rbc NNS cord-010119-t1x9gknd 12946 33 in in IN cord-010119-t1x9gknd 12946 34 a a DT cord-010119-t1x9gknd 12946 35 Level level NN cord-010119-t1x9gknd 12947 1 I -PRON- PRP cord-010119-t1x9gknd 12947 2 Bellevue Bellevue NNP cord-010119-t1x9gknd 12947 3 Hospital Hospital NNP cord-010119-t1x9gknd 12947 4 - - HYPH cord-010119-t1x9gknd 12947 5 NYULMC NYULMC NNP cord-010119-t1x9gknd 12948 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12948 2 hospital hospital NN cord-010119-t1x9gknd 12948 3 is be VBZ cord-010119-t1x9gknd 12948 4 a a DT cord-010119-t1x9gknd 12948 5 level level NN cord-010119-t1x9gknd 12948 6 I -PRON- PRP cord-010119-t1x9gknd 12948 7 trauma trauma NN cord-010119-t1x9gknd 12948 8 center center NN cord-010119-t1x9gknd 12948 9 serving serve VBG cord-010119-t1x9gknd 12948 10 a a DT cord-010119-t1x9gknd 12948 11 diverse diverse JJ cord-010119-t1x9gknd 12948 12 predominately predominately RB cord-010119-t1x9gknd 12948 13 non non JJ cord-010119-t1x9gknd 12948 14 - - JJ cord-010119-t1x9gknd 12948 15 Caucasian caucasian JJ cord-010119-t1x9gknd 12948 16 population population NN cord-010119-t1x9gknd 12948 17 . . . cord-010119-t1x9gknd 12949 1 Historically historically RB cord-010119-t1x9gknd 12949 2 we -PRON- PRP cord-010119-t1x9gknd 12949 3 stocked stock VBD cord-010119-t1x9gknd 12949 4 our -PRON- PRP$ cord-010119-t1x9gknd 12949 5 trauma trauma NN cord-010119-t1x9gknd 12949 6 blood blood NN cord-010119-t1x9gknd 12949 7 bank bank NN cord-010119-t1x9gknd 12949 8 monitored monitor VBD cord-010119-t1x9gknd 12949 9 refrigerator refrigerator NN cord-010119-t1x9gknd 12949 10 with with IN cord-010119-t1x9gknd 12949 11 2 2 CD cord-010119-t1x9gknd 12949 12 O o NN cord-010119-t1x9gknd 12949 13 - - HYPH cord-010119-t1x9gknd 12949 14 negative negative JJ cord-010119-t1x9gknd 12949 15 RBCs rbc NNS cord-010119-t1x9gknd 12949 16 . . . cord-010119-t1x9gknd 12950 1 Trauma trauma NN cord-010119-t1x9gknd 12950 2 requested request VBD cord-010119-t1x9gknd 12950 3 that that IN cord-010119-t1x9gknd 12950 4 we -PRON- PRP cord-010119-t1x9gknd 12950 5 stock stock VBP cord-010119-t1x9gknd 12950 6 additional additional JJ cord-010119-t1x9gknd 12950 7 RBCs rbc NNS cord-010119-t1x9gknd 12950 8 to to TO cord-010119-t1x9gknd 12950 9 be be VB cord-010119-t1x9gknd 12950 10 able able JJ cord-010119-t1x9gknd 12950 11 to to TO cord-010119-t1x9gknd 12950 12 initiate initiate VB cord-010119-t1x9gknd 12950 13 a a DT cord-010119-t1x9gknd 12950 14 MTP MTP NNP cord-010119-t1x9gknd 12950 15 for for IN cord-010119-t1x9gknd 12950 16 multiple multiple JJ cord-010119-t1x9gknd 12950 17 patients patient NNS cord-010119-t1x9gknd 12950 18 at at IN cord-010119-t1x9gknd 12950 19 the the DT cord-010119-t1x9gknd 12950 20 same same JJ cord-010119-t1x9gknd 12950 21 time time NN cord-010119-t1x9gknd 12950 22 . . . cord-010119-t1x9gknd 12951 1 Believing believe VBG cord-010119-t1x9gknd 12951 2 that that IN cord-010119-t1x9gknd 12951 3 most most JJS cord-010119-t1x9gknd 12951 4 of of IN cord-010119-t1x9gknd 12951 5 our -PRON- PRP$ cord-010119-t1x9gknd 12951 6 trauma trauma NN cord-010119-t1x9gknd 12951 7 patients patient NNS cord-010119-t1x9gknd 12951 8 are be VBP cord-010119-t1x9gknd 12951 9 male male JJ cord-010119-t1x9gknd 12951 10 , , , cord-010119-t1x9gknd 12951 11 elderly elderly JJ cord-010119-t1x9gknd 12951 12 , , , cord-010119-t1x9gknd 12951 13 or or CC cord-010119-t1x9gknd 12951 14 Rh Rh NNP cord-010119-t1x9gknd 12951 15 - - HYPH cord-010119-t1x9gknd 12951 16 positive positive JJ cord-010119-t1x9gknd 12951 17 , , , cord-010119-t1x9gknd 12951 18 we -PRON- PRP cord-010119-t1x9gknd 12951 19 agreed agree VBD cord-010119-t1x9gknd 12951 20 add add VB cord-010119-t1x9gknd 12951 21 2 2 CD cord-010119-t1x9gknd 12951 22 type type NN cord-010119-t1x9gknd 12951 23 O o NN cord-010119-t1x9gknd 12951 24 - - HYPH cord-010119-t1x9gknd 12951 25 positive positive JJ cord-010119-t1x9gknd 12951 26 RBCs rbc NNS cord-010119-t1x9gknd 12951 27 to to IN cord-010119-t1x9gknd 12951 28 the the DT cord-010119-t1x9gknd 12951 29 stock stock NN cord-010119-t1x9gknd 12951 30 . . . cord-010119-t1x9gknd 12952 1 Rules rule NNS cord-010119-t1x9gknd 12952 2 for for IN cord-010119-t1x9gknd 12952 3 determining determine VBG cord-010119-t1x9gknd 12952 4 which which WDT cord-010119-t1x9gknd 12952 5 units unit NNS cord-010119-t1x9gknd 12952 6 to to TO cord-010119-t1x9gknd 12952 7 use use VB cord-010119-t1x9gknd 12952 8 were be VBD cord-010119-t1x9gknd 12952 9 established establish VBN cord-010119-t1x9gknd 12952 10 . . . cord-010119-t1x9gknd 12953 1 O o UH cord-010119-t1x9gknd 12953 2 - - HYPH cord-010119-t1x9gknd 12953 3 positive positive JJ cord-010119-t1x9gknd 12953 4 RBCs rbc NNS cord-010119-t1x9gknd 12953 5 are be VBP cord-010119-t1x9gknd 12953 6 to to TO cord-010119-t1x9gknd 12953 7 be be VB cord-010119-t1x9gknd 12953 8 given give VBN cord-010119-t1x9gknd 12953 9 to to IN cord-010119-t1x9gknd 12953 10 1A 1a CD cord-010119-t1x9gknd 12953 11 ) ) -RRB- cord-010119-t1x9gknd 12954 1 all all DT cord-010119-t1x9gknd 12954 2 adult adult NN cord-010119-t1x9gknd 12954 3 males male NNS cord-010119-t1x9gknd 12954 4 ( ( -LRB- cord-010119-t1x9gknd 12954 5 AM AM NNP cord-010119-t1x9gknd 12954 6 ) ) -RRB- cord-010119-t1x9gknd 12954 7 , , , cord-010119-t1x9gknd 12954 8 1B 1b LS cord-010119-t1x9gknd 12954 9 ) ) -RRB- cord-010119-t1x9gknd 12954 10 women woman NNS cord-010119-t1x9gknd 12954 11 of of IN cord-010119-t1x9gknd 12954 12 non non JJ cord-010119-t1x9gknd 12954 13 - - JJ cord-010119-t1x9gknd 12954 14 childbearing childbearing JJ cord-010119-t1x9gknd 12954 15 age age NN cord-010119-t1x9gknd 12954 16 ( ( -LRB- cord-010119-t1x9gknd 12954 17 WNCBA WNCBA NNP cord-010119-t1x9gknd 12954 18 ) ) -RRB- cord-010119-t1x9gknd 12954 19 , , , cord-010119-t1x9gknd 12954 20 and and CC cord-010119-t1x9gknd 12954 21 1C 1c LS cord-010119-t1x9gknd 12954 22 ) ) -RRB- cord-010119-t1x9gknd 12954 23 if if IN cord-010119-t1x9gknd 12954 24 both both DT cord-010119-t1x9gknd 12954 25 O o NN cord-010119-t1x9gknd 12954 26 - - HYPH cord-010119-t1x9gknd 12954 27 negative negative JJ cord-010119-t1x9gknd 12954 28 RBCs rbc NNS cord-010119-t1x9gknd 12954 29 were be VBD cord-010119-t1x9gknd 12954 30 used use VBN cord-010119-t1x9gknd 12954 31 but but CC cord-010119-t1x9gknd 12954 32 not not RB cord-010119-t1x9gknd 12954 33 yet yet RB cord-010119-t1x9gknd 12954 34 restocked restock VBN cord-010119-t1x9gknd 12954 35 , , , cord-010119-t1x9gknd 12954 36 and and CC cord-010119-t1x9gknd 12954 37 O o NN cord-010119-t1x9gknd 12954 38 - - HYPH cord-010119-t1x9gknd 12954 39 negative negative JJ cord-010119-t1x9gknd 12954 40 RBCs rbc NNS cord-010119-t1x9gknd 12954 41 are be VBP cord-010119-t1x9gknd 12954 42 to to TO cord-010119-t1x9gknd 12954 43 be be VB cord-010119-t1x9gknd 12954 44 given give VBN cord-010119-t1x9gknd 12954 45 to to IN cord-010119-t1x9gknd 12954 46 2A 2a CD cord-010119-t1x9gknd 12954 47 ) ) -RRB- cord-010119-t1x9gknd 12954 48 women woman NNS cord-010119-t1x9gknd 12954 49 of of IN cord-010119-t1x9gknd 12954 50 childbearing childbeare VBG cord-010119-t1x9gknd 12954 51 age age NN cord-010119-t1x9gknd 12954 52 ( ( -LRB- cord-010119-t1x9gknd 12954 53 WCBA WCBA NNP cord-010119-t1x9gknd 12954 54 ) ) -RRB- cord-010119-t1x9gknd 12954 55 and and CC cord-010119-t1x9gknd 12954 56 2B 2b CD cord-010119-t1x9gknd 12954 57 ) ) -RRB- cord-010119-t1x9gknd 12954 58 children child NNS cord-010119-t1x9gknd 12954 59 until until IN cord-010119-t1x9gknd 12954 60 the the DT cord-010119-t1x9gknd 12954 61 patient patient NN cord-010119-t1x9gknd 12954 62 's 's POS cord-010119-t1x9gknd 12954 63 ABORh ABORh NNP cord-010119-t1x9gknd 12954 64 type type NN cord-010119-t1x9gknd 12954 65 are be VBP cord-010119-t1x9gknd 12954 66 determined determine VBN cord-010119-t1x9gknd 12954 67 . . . cord-010119-t1x9gknd 12955 1 We -PRON- PRP cord-010119-t1x9gknd 12955 2 sought seek VBD cord-010119-t1x9gknd 12955 3 to to TO cord-010119-t1x9gknd 12955 4 assess assess VB cord-010119-t1x9gknd 12955 5 the the DT cord-010119-t1x9gknd 12955 6 impact impact NN cord-010119-t1x9gknd 12955 7 of of IN cord-010119-t1x9gknd 12955 8 this this DT cord-010119-t1x9gknd 12955 9 change change NN cord-010119-t1x9gknd 12955 10 on on IN cord-010119-t1x9gknd 12955 11 our -PRON- PRP$ cord-010119-t1x9gknd 12955 12 usage usage NN cord-010119-t1x9gknd 12955 13 and and CC cord-010119-t1x9gknd 12955 14 purchases purchase NNS cord-010119-t1x9gknd 12955 15 of of IN cord-010119-t1x9gknd 12955 16 O o NN cord-010119-t1x9gknd 12955 17 - - HYPH cord-010119-t1x9gknd 12955 18 negative negative JJ cord-010119-t1x9gknd 12955 19 RBCs rbc NNS cord-010119-t1x9gknd 12955 20 . . . cord-010119-t1x9gknd 12956 1 Study Study NNP cord-010119-t1x9gknd 12956 2 Design Design NNP cord-010119-t1x9gknd 12956 3 / / SYM cord-010119-t1x9gknd 12956 4 Method method NN cord-010119-t1x9gknd 12956 5 : : : cord-010119-t1x9gknd 12957 1 All all DT cord-010119-t1x9gknd 12957 2 patients patient NNS cord-010119-t1x9gknd 12957 3 issued issue VBD cord-010119-t1x9gknd 12957 4 emergency emergency NN cord-010119-t1x9gknd 12957 5 release release NN cord-010119-t1x9gknd 12957 6 trauma trauma NN cord-010119-t1x9gknd 12957 7 RBCs rbc NNS cord-010119-t1x9gknd 12957 8 following follow VBG cord-010119-t1x9gknd 12957 9 the the DT cord-010119-t1x9gknd 12957 10 addition addition NN cord-010119-t1x9gknd 12957 11 of of IN cord-010119-t1x9gknd 12957 12 O o NN cord-010119-t1x9gknd 12957 13 - - HYPH cord-010119-t1x9gknd 12957 14 positive positive JJ cord-010119-t1x9gknd 12957 15 RBCs rbc NNS cord-010119-t1x9gknd 12957 16 were be VBD cord-010119-t1x9gknd 12957 17 assessed assess VBN cord-010119-t1x9gknd 12957 18 3 3 CD cord-010119-t1x9gknd 12957 19 % % NN cord-010119-t1x9gknd 12957 20 ) ) -RRB- cord-010119-t1x9gknd 12957 21 would would MD cord-010119-t1x9gknd 12957 22 have have VB cord-010119-t1x9gknd 12957 23 needed need VBN cord-010119-t1x9gknd 12957 24 to to TO cord-010119-t1x9gknd 12957 25 be be VB cord-010119-t1x9gknd 12957 26 O o NN cord-010119-t1x9gknd 12957 27 - - HYPH cord-010119-t1x9gknd 12957 28 negative negative JJ cord-010119-t1x9gknd 12957 29 . . . cord-010119-t1x9gknd 12958 1 The the DT cord-010119-t1x9gknd 12958 2 addition addition NN cord-010119-t1x9gknd 12958 3 of of IN cord-010119-t1x9gknd 12958 4 O o NN cord-010119-t1x9gknd 12958 5 - - HYPH cord-010119-t1x9gknd 12958 6 positive positive JJ cord-010119-t1x9gknd 12958 7 RBCs rbc NNS cord-010119-t1x9gknd 12958 8 to to IN cord-010119-t1x9gknd 12958 9 our -PRON- PRP$ cord-010119-t1x9gknd 12958 10 trauma trauma NN cord-010119-t1x9gknd 12958 11 refrigerator refrigerator NN cord-010119-t1x9gknd 12958 12 will will MD cord-010119-t1x9gknd 12958 13 enable enable VB cord-010119-t1x9gknd 12958 14 us -PRON- PRP cord-010119-t1x9gknd 12958 15 to to TO cord-010119-t1x9gknd 12958 16 markedly markedly RB cord-010119-t1x9gknd 12958 17 reduce reduce VB cord-010119-t1x9gknd 12958 18 our -PRON- PRP$ cord-010119-t1x9gknd 12958 19 purchases purchase NNS cord-010119-t1x9gknd 12958 20 of of IN cord-010119-t1x9gknd 12958 21 O o NN cord-010119-t1x9gknd 12958 22 - - HYPH cord-010119-t1x9gknd 12958 23 negative negative JJ cord-010119-t1x9gknd 12958 24 RBCs rbc NNS cord-010119-t1x9gknd 12958 25 . . . cord-010119-t1x9gknd 12959 1 AP73 AP73 NNP cord-010119-t1x9gknd 12959 2 Saving Saving NNP cord-010119-t1x9gknd 12959 3 Apheresis Apheresis NNP cord-010119-t1x9gknd 12959 4 Platelets Platelets NNPS cord-010119-t1x9gknd 12959 5 through through IN cord-010119-t1x9gknd 12959 6 Use Use NNP cord-010119-t1x9gknd 12959 7 of of IN cord-010119-t1x9gknd 12959 8 Verax Verax NNP cord-010119-t1x9gknd 12959 9 Point Point NNP cord-010119-t1x9gknd 12959 10 of of IN cord-010119-t1x9gknd 12959 11 Care Care NNP cord-010119-t1x9gknd 12959 12 Testing Testing NNP cord-010119-t1x9gknd 12959 13 Jennifer Jennifer NNP cord-010119-t1x9gknd 12959 14 Rhamy Rhamy NNP cord-010119-t1x9gknd 12960 1 * * NFP cord-010119-t1x9gknd 12960 2 1 1 CD cord-010119-t1x9gknd 12960 3 and and CC cord-010119-t1x9gknd 12960 4 Rebecca Rebecca NNP cord-010119-t1x9gknd 12960 5 Wride Wride NNP cord-010119-t1x9gknd 12960 6 2 2 CD cord-010119-t1x9gknd 12960 7 . . . cord-010119-t1x9gknd 12961 1 1 1 LS cord-010119-t1x9gknd 12962 1 St. St. NNP cord-010119-t1x9gknd 12962 2 Mary Mary NNP cord-010119-t1x9gknd 12962 3 's 's POS cord-010119-t1x9gknd 12962 4 Regional Regional NNP cord-010119-t1x9gknd 12962 5 Blood Blood NNP cord-010119-t1x9gknd 12962 6 Donor Donor NNP cord-010119-t1x9gknd 12962 7 Center Center NNP cord-010119-t1x9gknd 12962 8 , , , cord-010119-t1x9gknd 12962 9 2 2 CD cord-010119-t1x9gknd 12962 10 St. St. NNP cord-010119-t1x9gknd 12962 11 Mary Mary NNP cord-010119-t1x9gknd 12962 12 's 's POS cord-010119-t1x9gknd 12962 13 Regional Regional NNP cord-010119-t1x9gknd 12962 14 Medical Medical NNP cord-010119-t1x9gknd 12962 15 Center Center NNP cord-010119-t1x9gknd 12962 16 Background Background NNP cord-010119-t1x9gknd 12962 17 / / SYM cord-010119-t1x9gknd 12962 18 Case Case NNP cord-010119-t1x9gknd 12962 19 Studies Studies NNPS cord-010119-t1x9gknd 12962 20 : : : cord-010119-t1x9gknd 12963 1 Our -PRON- PRP$ cord-010119-t1x9gknd 12963 2 rural rural JJ cord-010119-t1x9gknd 12963 3 hospital hospital NN cord-010119-t1x9gknd 12963 4 - - HYPH cord-010119-t1x9gknd 12963 5 based base VBN cord-010119-t1x9gknd 12963 6 blood blood NN cord-010119-t1x9gknd 12963 7 center center NN cord-010119-t1x9gknd 12963 8 serves serve VBZ cord-010119-t1x9gknd 12963 9 17 17 CD cord-010119-t1x9gknd 12963 10 hospitals hospital NNS cord-010119-t1x9gknd 12963 11 and and CC cord-010119-t1x9gknd 12963 12 a a DT cord-010119-t1x9gknd 12963 13 diverse diverse JJ cord-010119-t1x9gknd 12963 14 patient patient JJ cord-010119-t1x9gknd 12963 15 population population NN cord-010119-t1x9gknd 12963 16 including include VBG cord-010119-t1x9gknd 12963 17 acute acute JJ cord-010119-t1x9gknd 12963 18 trauma trauma NN cord-010119-t1x9gknd 12963 19 . . . cord-010119-t1x9gknd 12964 1 Because because IN cord-010119-t1x9gknd 12964 2 of of IN cord-010119-t1x9gknd 12964 3 the the DT cord-010119-t1x9gknd 12964 4 varying varying NN cord-010119-t1x9gknd 12964 5 need need NN cord-010119-t1x9gknd 12964 6 for for IN cord-010119-t1x9gknd 12964 7 platelet platelet NN cord-010119-t1x9gknd 12964 8 products product NNS cord-010119-t1x9gknd 12964 9 ( ( -LRB- cord-010119-t1x9gknd 12964 10 varies vary VBZ cord-010119-t1x9gknd 12964 11 between between IN cord-010119-t1x9gknd 12964 12 0 0 CD cord-010119-t1x9gknd 12964 13 and and CC cord-010119-t1x9gknd 12964 14 8 8 CD cord-010119-t1x9gknd 12964 15 per per IN cord-010119-t1x9gknd 12964 16 day day NN cord-010119-t1x9gknd 12964 17 in in IN cord-010119-t1x9gknd 12964 18 2017 2017 CD cord-010119-t1x9gknd 12964 19 ) ) -RRB- cord-010119-t1x9gknd 12964 20 , , , cord-010119-t1x9gknd 12964 21 we -PRON- PRP cord-010119-t1x9gknd 12964 22 investigated investigate VBD cord-010119-t1x9gknd 12964 23 the the DT cord-010119-t1x9gknd 12964 24 use use NN cord-010119-t1x9gknd 12964 25 of of IN cord-010119-t1x9gknd 12964 26 the the DT cord-010119-t1x9gknd 12964 27 Verax Verax NNP cord-010119-t1x9gknd 12964 28 point point NN cord-010119-t1x9gknd 12964 29 - - HYPH cord-010119-t1x9gknd 12964 30 of of IN cord-010119-t1x9gknd 12964 31 - - HYPH cord-010119-t1x9gknd 12964 32 care care NN cord-010119-t1x9gknd 12964 33 test test NN cord-010119-t1x9gknd 12964 34 to to TO cord-010119-t1x9gknd 12964 35 better better RB cord-010119-t1x9gknd 12964 36 manage manage VB cord-010119-t1x9gknd 12964 37 our -PRON- PRP$ cord-010119-t1x9gknd 12964 38 valuable valuable JJ cord-010119-t1x9gknd 12964 39 inventory inventory NN cord-010119-t1x9gknd 12964 40 Barrett Barrett NNP cord-010119-t1x9gknd 12964 41 Lawson Lawson NNP cord-010119-t1x9gknd 12964 42 2 2 CD cord-010119-t1x9gknd 12964 43 and and CC cord-010119-t1x9gknd 12964 44 Jun Jun NNP cord-010119-t1x9gknd 12964 45 Teruya Teruya NNP cord-010119-t1x9gknd 12964 46 1,2 1,2 CD cord-010119-t1x9gknd 12964 47 . . . cord-010119-t1x9gknd 12965 1 1 1 LS cord-010119-t1x9gknd 12966 1 Texas Texas NNP cord-010119-t1x9gknd 12966 2 Children Children NNP cord-010119-t1x9gknd 12966 3 's 's POS cord-010119-t1x9gknd 12966 4 Hospital Hospital NNP cord-010119-t1x9gknd 12966 5 , , , cord-010119-t1x9gknd 12966 6 2 2 CD cord-010119-t1x9gknd 12966 7 Baylor Baylor NNP cord-010119-t1x9gknd 12966 8 College College NNP cord-010119-t1x9gknd 12966 9 of of IN cord-010119-t1x9gknd 12966 10 Medicine Medicine NNP cord-010119-t1x9gknd 12966 11 AP127 AP127 NNP cord-010119-t1x9gknd 12966 12 Vision Vision NNP cord-010119-t1x9gknd 12966 13 Titers Titers NNP cord-010119-t1x9gknd 12966 14 --Easier --easier RBR cord-010119-t1x9gknd 12966 15 or or CC cord-010119-t1x9gknd 12966 16 Problematic problematic JJ cord-010119-t1x9gknd 12966 17 ? ? . cord-010119-t1x9gknd 12966 18 _SP cord-010119-t1x9gknd 12967 1 ( ( -LRB- cord-010119-t1x9gknd 12967 2 Table table NN cord-010119-t1x9gknd 12967 3 1 1 CD cord-010119-t1x9gknd 12967 4 ) ) -RRB- cord-010119-t1x9gknd 12967 5 . . . cord-010119-t1x9gknd 12968 1 Results result NNS cord-010119-t1x9gknd 12968 2 / / SYM cord-010119-t1x9gknd 12968 3 Findings finding NNS cord-010119-t1x9gknd 12968 4 : : : cord-010119-t1x9gknd 12969 1 Post Post NNP cord-010119-t1x9gknd 12969 2 INTERCEPT INTERCEPT NNP cord-010119-t1x9gknd 12969 3 , , , cord-010119-t1x9gknd 12969 4 T T NNP cord-010119-t1x9gknd 12969 5 had have VBD cord-010119-t1x9gknd 12969 6 volumes volume NNS cord-010119-t1x9gknd 12969 7 of of IN cord-010119-t1x9gknd 12969 8 261 261 CD cord-010119-t1x9gknd 12969 9 - - SYM cord-010119-t1x9gknd 12969 10 320 320 CD cord-010119-t1x9gknd 12969 11 mL ml NN cord-010119-t1x9gknd 12969 12 , , , cord-010119-t1x9gknd 12969 13 with with IN cord-010119-t1x9gknd 12969 14 98 98 CD cord-010119-t1x9gknd 12969 15 6 6 CD cord-010119-t1x9gknd 12969 16 4 4 CD cord-010119-t1x9gknd 12969 17 % % NN cord-010119-t1x9gknd 12969 18 hemoglobin hemoglobin NN cord-010119-t1x9gknd 12969 19 ( ( -LRB- cord-010119-t1x9gknd 12969 20 Hb Hb NNP cord-010119-t1x9gknd 12969 21 ) ) -RRB- cord-010119-t1x9gknd 12969 22 recovery recovery NN cord-010119-t1x9gknd 12969 23 . . . cord-010119-t1x9gknd 12970 1 T T NNP cord-010119-t1x9gknd 12970 2 had have VBD cord-010119-t1x9gknd 12970 3 10-fold 10-fold CD cord-010119-t1x9gknd 12970 4 less less RBR cord-010119-t1x9gknd 12970 5 extracellular extracellular JJ cord-010119-t1x9gknd 12970 6 protein protein NN cord-010119-t1x9gknd 12970 7 than than IN cord-010119-t1x9gknd 12970 8 C. C. NNP cord-010119-t1x9gknd 12971 1 After after IN cord-010119-t1x9gknd 12971 2 35 35 CD cord-010119-t1x9gknd 12971 3 days day NNS cord-010119-t1x9gknd 12971 4 of of IN cord-010119-t1x9gknd 12971 5 storage storage NN cord-010119-t1x9gknd 12971 6 T T NNP cord-010119-t1x9gknd 12971 7 had have VBD cord-010119-t1x9gknd 12971 8 higher high JJR cord-010119-t1x9gknd 12971 9 ATP ATP NNP cord-010119-t1x9gknd 12971 10 and and CC cord-010119-t1x9gknd 12971 11 Na Na NNP cord-010119-t1x9gknd 12971 12 1 1 CD cord-010119-t1x9gknd 12971 13 than than IN cord-010119-t1x9gknd 12971 14 C C NNP cord-010119-t1x9gknd 12971 15 while while IN cord-010119-t1x9gknd 12971 16 lactate lactate NN cord-010119-t1x9gknd 12971 17 and and CC cord-010119-t1x9gknd 12971 18 hemolysis hemolysis NN cord-010119-t1x9gknd 12971 19 were be VBD cord-010119-t1x9gknd 12971 20 lower low JJR cord-010119-t1x9gknd 12971 21 . . . cord-010119-t1x9gknd 12972 1 Hct Hct NNP cord-010119-t1x9gknd 12972 2 , , , cord-010119-t1x9gknd 12972 3 pH ph NN cord-010119-t1x9gknd 12972 4 , , , cord-010119-t1x9gknd 12972 5 K K NNP cord-010119-t1x9gknd 12972 6 1 1 CD cord-010119-t1x9gknd 12972 7 and and CC cord-010119-t1x9gknd 12972 8 glucose glucose NN cord-010119-t1x9gknd 12972 9 were be VBD cord-010119-t1x9gknd 12972 10 equivalent equivalent JJ cord-010119-t1x9gknd 12972 11 between between IN cord-010119-t1x9gknd 12972 12 T T NNP cord-010119-t1x9gknd 12972 13 and and CC cord-010119-t1x9gknd 12972 14 C C NNP cord-010119-t1x9gknd 12972 15 on on IN cord-010119-t1x9gknd 12972 16 D35 D35 NNP cord-010119-t1x9gknd 12972 17 . . . cord-010119-t1x9gknd 12973 1 D35 d35 JJ cord-010119-t1x9gknd 12973 2 hemolysis hemolysis NN cord-010119-t1x9gknd 12973 3 for for IN cord-010119-t1x9gknd 12973 4 T T NNP cord-010119-t1x9gknd 12973 5 was be VBD cord-010119-t1x9gknd 12973 6 0.08 0.08 CD cord-010119-t1x9gknd 12973 7 - - SYM cord-010119-t1x9gknd 12973 8 0.31 0.31 CD cord-010119-t1x9gknd 12973 9 % % NN cord-010119-t1x9gknd 12973 10 , , , cord-010119-t1x9gknd 12973 11 while while IN cord-010119-t1x9gknd 12973 12 for for IN cord-010119-t1x9gknd 12973 13 C c NN cord-010119-t1x9gknd 12973 14 it -PRON- PRP cord-010119-t1x9gknd 12973 15 was be VBD cord-010119-t1x9gknd 12973 16 0.10 0.10 CD cord-010119-t1x9gknd 12973 17 - - SYM cord-010119-t1x9gknd 12973 18 0.57 0.57 CD cord-010119-t1x9gknd 12973 19 % % NN cord-010119-t1x9gknd 12973 20 . . . cord-010119-t1x9gknd 12974 1 T T NNP cord-010119-t1x9gknd 12974 2 and and CC cord-010119-t1x9gknd 12974 3 C C NNP cord-010119-t1x9gknd 12974 4 ATP ATP NNP cord-010119-t1x9gknd 12974 5 was be VBD cord-010119-t1x9gknd 12974 6 > > XX cord-010119-t1x9gknd 12975 1 2mmol 2mmol LS cord-010119-t1x9gknd 12976 1 /g /g NNP cord-010119-t1x9gknd 12976 2 Hb Hb NNP cord-010119-t1x9gknd 12976 3 , , , cord-010119-t1x9gknd 12976 4 the the DT cord-010119-t1x9gknd 12976 5 level level NN cord-010119-t1x9gknd 12976 6 of of IN cord-010119-t1x9gknd 12976 7 ATP ATP NNP cord-010119-t1x9gknd 12976 8 associated associate VBN cord-010119-t1x9gknd 12976 9 with with IN cord-010119-t1x9gknd 12976 10 effective effective JJ cord-010119-t1x9gknd 12976 11 RBC RBC NNP cord-010119-t1x9gknd 12976 12 viability viability NN cord-010119-t1x9gknd 12976 13 , , , cord-010119-t1x9gknd 12976 14 throughout throughout IN cord-010119-t1x9gknd 12976 15 storage storage NN cord-010119-t1x9gknd 12976 16 ( ( -LRB- cord-010119-t1x9gknd 12976 17 Table table NN cord-010119-t1x9gknd 12976 18 1 1 CD cord-010119-t1x9gknd 12976 19 ) ) -RRB- cord-010119-t1x9gknd 12976 20 . . . cord-010119-t1x9gknd 12977 1 Hematocrit hematocrit NN cord-010119-t1x9gknd 12977 2 ( ( -LRB- cord-010119-t1x9gknd 12977 3 Hct Hct NNP cord-010119-t1x9gknd 12977 4 , , , cord-010119-t1x9gknd 12977 5 % % NN cord-010119-t1x9gknd 12977 6 ) ) -RRB- cord-010119-t1x9gknd 12978 1 58.5 58.5 CD cord-010119-t1x9gknd 12978 2 6 6 CD cord-010119-t1x9gknd 12978 3 2.5 2.5 CD cord-010119-t1x9gknd 12978 4 * * NFP cord-010119-t1x9gknd 12978 5 56.3 56.3 CD cord-010119-t1x9gknd 12978 6 6 6 CD cord-010119-t1x9gknd 12978 7 1.7 1.7 CD cord-010119-t1x9gknd 12978 8 60.8 60.8 CD cord-010119-t1x9gknd 12978 9 6 6 CD cord-010119-t1x9gknd 12978 10 2.7 2.7 CD cord-010119-t1x9gknd 12978 11 61.8 61.8 CD cord-010119-t1x9gknd 12978 12 6 6 CD cord-010119-t1x9gknd 12978 13 2.9 2.9 CD cord-010119-t1x9gknd 12978 14 Hemoglobin hemoglobin NN cord-010119-t1x9gknd 12978 15 ( ( -LRB- cord-010119-t1x9gknd 12978 16 g g NN cord-010119-t1x9gknd 12978 17 / / SYM cord-010119-t1x9gknd 12978 18 unit unit NN cord-010119-t1x9gknd 12978 19 ) ) -RRB- cord-010119-t1x9gknd 12978 20 59 59 CD cord-010119-t1x9gknd 12978 21 6 6 CD cord-010119-t1x9gknd 12978 22 7 7 CD cord-010119-t1x9gknd 12978 23 6 6 CD cord-010119-t1x9gknd 12978 24 0 0 CD cord-010119-t1x9gknd 12978 25 6 6 CD cord-010119-t1x9gknd 12978 26 4 4 CD cord-010119-t1x9gknd 12978 27 not not RB cord-010119-t1x9gknd 12978 28 measured measure VBN cord-010119-t1x9gknd 12978 29 Hemolysis Hemolysis NNP cord-010119-t1x9gknd 12978 30 ( ( -LRB- cord-010119-t1x9gknd 12978 31 % % NN cord-010119-t1x9gknd 12978 32 ) ) -RRB- cord-010119-t1x9gknd 12978 33 0.02 0.02 CD cord-010119-t1x9gknd 12979 1 6 6 CD cord-010119-t1x9gknd 12979 2 0.01 0.01 CD cord-010119-t1x9gknd 12979 3 * * NFP cord-010119-t1x9gknd 12979 4 0.06 0.06 CD cord-010119-t1x9gknd 12979 5 6 6 CD cord-010119-t1x9gknd 12979 6 0.04 0.04 CD cord-010119-t1x9gknd 12979 7 0.16 0.16 CD cord-010119-t1x9gknd 12979 8 6 6 CD cord-010119-t1x9gknd 12979 9 0.07 0.07 CD cord-010119-t1x9gknd 12979 10 * * NFP cord-010119-t1x9gknd 12979 11 0.29 0.29 CD cord-010119-t1x9gknd 12980 1 6 6 CD cord-010119-t1x9gknd 12980 2 0.14 0.14 CD cord-010119-t1x9gknd 12980 3 pH pH NNP cord-010119-t1x9gknd 12980 4 ( ( -LRB- cord-010119-t1x9gknd 12980 5 378C 378c CD cord-010119-t1x9gknd 12980 6 ) ) -RRB- cord-010119-t1x9gknd 12981 1 6.9 6.9 CD cord-010119-t1x9gknd 12981 2 6 6 CD cord-010119-t1x9gknd 12981 3 0.1 0.1 CD cord-010119-t1x9gknd 12981 4 * * NFP cord-010119-t1x9gknd 12981 5 7.3 7.3 CD cord-010119-t1x9gknd 12981 6 6 6 CD cord-010119-t1x9gknd 12981 7 0.1 0.1 CD cord-010119-t1x9gknd 12981 8 6.7 6.7 CD cord-010119-t1x9gknd 12981 9 6 6 CD cord-010119-t1x9gknd 12981 10 0.1 0.1 CD cord-010119-t1x9gknd 12981 11 6.6 6.6 CD cord-010119-t1x9gknd 12981 12 6 6 CD cord-010119-t1x9gknd 12981 13 0.1 0.1 CD cord-010119-t1x9gknd 12981 14 Total total NN cord-010119-t1x9gknd 12981 15 ATP ATP NNP cord-010119-t1x9gknd 12981 16 ( ( -LRB- cord-010119-t1x9gknd 12981 17 mmol mmol NN cord-010119-t1x9gknd 12981 18 / / SYM cord-010119-t1x9gknd 12981 19 g g NNP cord-010119-t1x9gknd 12981 20 Hb Hb NNP cord-010119-t1x9gknd 12981 21 ) ) -RRB- cord-010119-t1x9gknd 12981 22 7.7 7.7 CD cord-010119-t1x9gknd 12981 23 6 6 CD cord-010119-t1x9gknd 12981 24 0.5 0.5 CD cord-010119-t1x9gknd 12981 25 * * NFP cord-010119-t1x9gknd 12981 26 5.0 5.0 CD cord-010119-t1x9gknd 12981 27 6 6 CD cord-010119-t1x9gknd 12981 28 0.4 0.4 CD cord-010119-t1x9gknd 12981 29 4.6 4.6 CD cord-010119-t1x9gknd 12981 30 6 6 CD cord-010119-t1x9gknd 12981 31 0.6 0.6 CD cord-010119-t1x9gknd 12981 32 * * NFP cord-010119-t1x9gknd 12981 33 3.9 3.9 CD cord-010119-t1x9gknd 12981 34 6 6 CD cord-010119-t1x9gknd 12981 35 0.5 0.5 CD cord-010119-t1x9gknd 12981 36 K1 K1 NNP cord-010119-t1x9gknd 12981 37 ( ( -LRB- cord-010119-t1x9gknd 12981 38 mM mm CD cord-010119-t1x9gknd 12981 39 ) ) -RRB- cord-010119-t1x9gknd 12981 40 1.5 1.5 CD cord-010119-t1x9gknd 12981 41 6 6 CD cord-010119-t1x9gknd 12981 42 0.3 0.3 CD cord-010119-t1x9gknd 12981 43 * * NFP cord-010119-t1x9gknd 12981 44 5.7 5.7 CD cord-010119-t1x9gknd 12981 45 6 6 CD cord-010119-t1x9gknd 12981 46 2.5 2.5 CD cord-010119-t1x9gknd 12981 47 53 53 CD cord-010119-t1x9gknd 12981 48 . . . cord-010119-t1x9gknd 12982 1 TOTAL total JJ cord-010119-t1x9gknd 12982 2 _SP cord-010119-t1x9gknd 12982 3 TESTED test VBN cord-010119-t1x9gknd 12982 4 _SP cord-010119-t1x9gknd 12983 1 TOTAL total JJ cord-010119-t1x9gknd 12983 2 PLTS PLTS NNP cord-010119-t1x9gknd 12983 3 _SP cord-010119-t1x9gknd 12983 4 ISSUED ISSUED NNS cord-010119-t1x9gknd 12983 5 _SP cord-010119-t1x9gknd 12983 6 FEB FEB NNP cord-010119-t1x9gknd 12983 7 _SP cord-010119-t1x9gknd 12983 8 87 87 CD cord-010119-t1x9gknd 12983 9 _SP cord-010119-t1x9gknd 12984 1 121 121 CD cord-010119-t1x9gknd 12984 2 _SP cord-010119-t1x9gknd 12984 3 64 64 CD cord-010119-t1x9gknd 12984 4 _SP cord-010119-t1x9gknd 12985 1 48 48 CD cord-010119-t1x9gknd 12985 2 _SP cord-010119-t1x9gknd 12986 1 24 24 CD cord-010119-t1x9gknd 12986 2 _SP cord-010119-t1x9gknd 12987 1 185 185 CD cord-010119-t1x9gknd 12987 2 _SP cord-010119-t1x9gknd 12987 3 181 181 CD cord-010119-t1x9gknd 12987 4 _SP cord-010119-t1x9gknd 12988 1 MAR MAR NNP cord-010119-t1x9gknd 12988 2 _SP cord-010119-t1x9gknd 12988 3 226 226 CD cord-010119-t1x9gknd 12988 4 _SP cord-010119-t1x9gknd 12988 5 516 516 CD cord-010119-t1x9gknd 12988 6 _SP cord-010119-t1x9gknd 12989 1 342 342 CD cord-010119-t1x9gknd 12989 2 _SP cord-010119-t1x9gknd 12989 3 276 276 CD cord-010119-t1x9gknd 12989 4 _SP cord-010119-t1x9gknd 12989 5 133 133 CD cord-010119-t1x9gknd 12989 6 _SP cord-010119-t1x9gknd 12989 7 858 858 CD cord-010119-t1x9gknd 12989 8 _SP cord-010119-t1x9gknd 12989 9 757 757 CD cord-010119-t1x9gknd 12989 10 _SP cord-010119-t1x9gknd 12989 11 TOTALS totals VB cord-010119-t1x9gknd 12989 12 _SP cord-010119-t1x9gknd 12990 1 352 352 CD cord-010119-t1x9gknd 12990 2 _SP cord-010119-t1x9gknd 12990 3 730 730 CD cord-010119-t1x9gknd 12990 4 _SP cord-010119-t1x9gknd 12990 5 471 471 CD cord-010119-t1x9gknd 12990 6 _SP cord-010119-t1x9gknd 12990 7 375 375 CD cord-010119-t1x9gknd 12990 8 174 174 CD cord-010119-t1x9gknd 12990 9 1201 1201 CD cord-010119-t1x9gknd 12990 10 Table table NN cord-010119-t1x9gknd 12990 11 : : : cord-010119-t1x9gknd 12990 12 2 2 CD cord-010119-t1x9gknd 12990 13 . . . cord-010119-t1x9gknd 12991 1 Resident resident JJ cord-010119-t1x9gknd 12991 2 reports report VBZ cord-010119-t1x9gknd 12991 3 to to IN cord-010119-t1x9gknd 12991 4 the the DT cord-010119-t1x9gknd 12991 5 intranet intranet NN cord-010119-t1x9gknd 12991 6 " " `` cord-010119-t1x9gknd 12991 7 drop drop NN cord-010119-t1x9gknd 12991 8 box box NN cord-010119-t1x9gknd 12991 9 " " '' cord-010119-t1x9gknd 12991 10 increased increase VBD cord-010119-t1x9gknd 12991 11 from from IN cord-010119-t1x9gknd 12991 12 53.7 53.7 CD cord-010119-t1x9gknd 12991 13 % % NN cord-010119-t1x9gknd 12991 14 to to IN cord-010119-t1x9gknd 12991 15 69.3 69.3 CD cord-010119-t1x9gknd 12991 16 % % NN cord-010119-t1x9gknd 12991 17 to to TO cord-010119-t1x9gknd 12991 18 100 100 CD cord-010119-t1x9gknd 12991 19 % % NN cord-010119-t1x9gknd 12991 20 , , , cord-010119-t1x9gknd 12991 21 each each DT cord-010119-t1x9gknd 12991 22 over over IN cord-010119-t1x9gknd 12991 23 2 2 CD cord-010119-t1x9gknd 12991 24 month month NN cord-010119-t1x9gknd 12991 25 time time NN cord-010119-t1x9gknd 12991 26 spans span NNS cord-010119-t1x9gknd 12991 27 . . . cord-010119-t1x9gknd 12992 1 Conclusion conclusion NN cord-010119-t1x9gknd 12992 2 : : : cord-010119-t1x9gknd 12993 1 Safe safe JJ cord-010119-t1x9gknd 12993 2 transfusion transfusion NN cord-010119-t1x9gknd 12993 3 ordering ordering NN cord-010119-t1x9gknd 12993 4 requires require VBZ cord-010119-t1x9gknd 12993 5 a a DT cord-010119-t1x9gknd 12993 6 team team NN cord-010119-t1x9gknd 12993 7 approach approach NN cord-010119-t1x9gknd 12993 8 to to TO cord-010119-t1x9gknd 12993 9 ensure ensure VB cord-010119-t1x9gknd 12993 10 the the DT cord-010119-t1x9gknd 12993 11 right right JJ cord-010119-t1x9gknd 12993 12 information information NN cord-010119-t1x9gknd 12993 13 is be VBZ cord-010119-t1x9gknd 12993 14 available available JJ cord-010119-t1x9gknd 12993 15 to to IN cord-010119-t1x9gknd 12993 16 the the DT cord-010119-t1x9gknd 12993 17 ordering ordering NN cord-010119-t1x9gknd 12993 18 provider provider NN cord-010119-t1x9gknd 12993 19 at at IN cord-010119-t1x9gknd 12993 20 the the DT cord-010119-t1x9gknd 12993 21 right right JJ cord-010119-t1x9gknd 12993 22 time time NN cord-010119-t1x9gknd 12993 23 . . . cord-010119-t1x9gknd 12994 1 Safe safe JJ cord-010119-t1x9gknd 12994 2 ordering ordering NN cord-010119-t1x9gknd 12994 3 prevented prevent VBD cord-010119-t1x9gknd 12994 4 recurrent recurrent JJ cord-010119-t1x9gknd 12994 5 allergic allergic JJ cord-010119-t1x9gknd 12994 6 reactions reaction NNS cord-010119-t1x9gknd 12994 7 in in IN cord-010119-t1x9gknd 12994 8 our -PRON- PRP$ cord-010119-t1x9gknd 12994 9 patient patient JJ cord-010119-t1x9gknd 12994 10 population population NN cord-010119-t1x9gknd 12994 11 . . . cord-010119-t1x9gknd 12995 1 The the DT cord-010119-t1x9gknd 12995 2 TSO TSO NNP cord-010119-t1x9gknd 12995 3 plays play VBZ cord-010119-t1x9gknd 12995 4 a a DT cord-010119-t1x9gknd 12995 5 pivotal pivotal JJ cord-010119-t1x9gknd 12995 6 role role NN cord-010119-t1x9gknd 12995 7 in in IN cord-010119-t1x9gknd 12995 8 ensuring ensure VBG cord-010119-t1x9gknd 12995 9 the the DT cord-010119-t1x9gknd 12995 10 full full JJ cord-010119-t1x9gknd 12995 11 circle circle NN cord-010119-t1x9gknd 12995 12 of of IN cord-010119-t1x9gknd 12995 13 communication communication NN cord-010119-t1x9gknd 12995 14 occurs occur VBZ cord-010119-t1x9gknd 12995 15 . . . cord-010119-t1x9gknd 12996 1 Processes process NNS cord-010119-t1x9gknd 12996 2 that that WDT cord-010119-t1x9gknd 12996 3 integrated integrate VBD cord-010119-t1x9gknd 12996 4 the the DT cord-010119-t1x9gknd 12996 5 pathology pathology NN cord-010119-t1x9gknd 12996 6 resident resident NN cord-010119-t1x9gknd 12996 7 improved improve VBD cord-010119-t1x9gknd 12996 8 with with IN cord-010119-t1x9gknd 12996 9 PDSA PDSA NNP cord-010119-t1x9gknd 12996 10 cycles cycle NNS cord-010119-t1x9gknd 12996 11 and and CC cord-010119-t1x9gknd 12996 12 impacted impact VBD cord-010119-t1x9gknd 12996 13 the the DT cord-010119-t1x9gknd 12996 14 quality quality NN cord-010119-t1x9gknd 12996 15 and and CC cord-010119-t1x9gknd 12996 16 timeliness timeliness NN cord-010119-t1x9gknd 12996 17 of of IN cord-010119-t1x9gknd 12996 18 hand hand NN cord-010119-t1x9gknd 12996 19 off off RP cord-010119-t1x9gknd 12996 20 . . . cord-010119-t1x9gknd 12997 1 Finally finally RB cord-010119-t1x9gknd 12997 2 , , , cord-010119-t1x9gknd 12997 3 the the DT cord-010119-t1x9gknd 12997 4 data datum NNS cord-010119-t1x9gknd 12997 5 provided provide VBN cord-010119-t1x9gknd 12997 6 from from IN cord-010119-t1x9gknd 12997 7 the the DT cord-010119-t1x9gknd 12997 8 residents resident NNS cord-010119-t1x9gknd 12997 9 enabled enable VBD cord-010119-t1x9gknd 12997 10 efficient efficient JJ cord-010119-t1x9gknd 12997 11 participation participation NN cord-010119-t1x9gknd 12997 12 in in IN cord-010119-t1x9gknd 12997 13 hemovigilance hemovigilance NN cord-010119-t1x9gknd 12997 14 . . . cord-010119-t1x9gknd 12998 1 Decreasing decrease VBG cord-010119-t1x9gknd 12998 2 Results result NNS cord-010119-t1x9gknd 12999 1 /Finding /finde VBG cord-010119-t1x9gknd 12999 2 : : : cord-010119-t1x9gknd 13000 1 The the DT cord-010119-t1x9gknd 13000 2 main main JJ cord-010119-t1x9gknd 13000 3 root root NN cord-010119-t1x9gknd 13000 4 cause cause NN cord-010119-t1x9gknd 13000 5 determined determine VBN cord-010119-t1x9gknd 13000 6 was be VBD cord-010119-t1x9gknd 13000 7 that that IN cord-010119-t1x9gknd 13000 8 there there EX cord-010119-t1x9gknd 13000 9 was be VBD cord-010119-t1x9gknd 13000 10 no no DT cord-010119-t1x9gknd 13000 11 standard standard JJ cord-010119-t1x9gknd 13000 12 work work NN cord-010119-t1x9gknd 13000 13 process process NN cord-010119-t1x9gknd 13000 14 . . . cord-010119-t1x9gknd 13001 1 SOPs sop NNS cord-010119-t1x9gknd 13001 2 were be VBD cord-010119-t1x9gknd 13001 3 being be VBG cord-010119-t1x9gknd 13001 4 followed follow VBN cord-010119-t1x9gknd 13001 5 but but CC cord-010119-t1x9gknd 13001 6 there there EX cord-010119-t1x9gknd 13001 7 was be VBD cord-010119-t1x9gknd 13001 8 no no DT cord-010119-t1x9gknd 13001 9 standard standard JJ cord-010119-t1x9gknd 13001 10 work work NN cord-010119-t1x9gknd 13001 11 process process NN cord-010119-t1x9gknd 13001 12 that that WDT cord-010119-t1x9gknd 13001 13 included include VBD cord-010119-t1x9gknd 13001 14 the the DT cord-010119-t1x9gknd 13001 15 details detail NNS cord-010119-t1x9gknd 13001 16 so so IN cord-010119-t1x9gknd 13001 17 testing testing NN cord-010119-t1x9gknd 13001 18 was be VBD cord-010119-t1x9gknd 13001 19 not not RB cord-010119-t1x9gknd 13001 20 following follow VBG cord-010119-t1x9gknd 13001 21 the the DT cord-010119-t1x9gknd 13001 22 most most RBS cord-010119-t1x9gknd 13001 23 efficient efficient JJ cord-010119-t1x9gknd 13001 24 work work NN cord-010119-t1x9gknd 13001 25 flow flow NN cord-010119-t1x9gknd 13001 26 . . . cord-010119-t1x9gknd 13002 1 Counter counter NN cord-010119-t1x9gknd 13002 2 measures measure NNS cord-010119-t1x9gknd 13002 3 implemented implement VBD cord-010119-t1x9gknd 13002 4 included include VBD cord-010119-t1x9gknd 13002 5 implementing implement VBG cord-010119-t1x9gknd 13002 6 a a DT cord-010119-t1x9gknd 13002 7 standard standard JJ cord-010119-t1x9gknd 13002 8 work work NN cord-010119-t1x9gknd 13002 9 process process NN cord-010119-t1x9gknd 13002 10 , , , cord-010119-t1x9gknd 13002 11 visual visual JJ cord-010119-t1x9gknd 13002 12 cues cue NNS cord-010119-t1x9gknd 13002 13 were be VBD cord-010119-t1x9gknd 13002 14 added add VBN cord-010119-t1x9gknd 13002 15 to to IN cord-010119-t1x9gknd 13002 16 the the DT cord-010119-t1x9gknd 13002 17 work work NN cord-010119-t1x9gknd 13002 18 process process NN cord-010119-t1x9gknd 13002 19 , , , cord-010119-t1x9gknd 13002 20 and and CC cord-010119-t1x9gknd 13002 21 a a DT cord-010119-t1x9gknd 13002 22 samples sample NNS cord-010119-t1x9gknd 13002 23 awaiting await VBG cord-010119-t1x9gknd 13002 24 testing testing NN cord-010119-t1x9gknd 13002 25 report report NN cord-010119-t1x9gknd 13002 26 was be VBD cord-010119-t1x9gknd 13002 27 created create VBN cord-010119-t1x9gknd 13002 28 for for IN cord-010119-t1x9gknd 13002 29 the the DT cord-010119-t1x9gknd 13002 30 Batch Batch NNP cord-010119-t1x9gknd 13002 31 Release Release NNP cord-010119-t1x9gknd 13002 32 Department Department NNP cord-010119-t1x9gknd 13002 33 . . . cord-010119-t1x9gknd 13003 1 Specific specific JJ cord-010119-t1x9gknd 13003 2 locations location NNS cord-010119-t1x9gknd 13003 3 were be VBD cord-010119-t1x9gknd 13003 4 identified identify VBN cord-010119-t1x9gknd 13003 5 within within IN cord-010119-t1x9gknd 13003 6 the the DT cord-010119-t1x9gknd 13003 7 work work NN cord-010119-t1x9gknd 13003 8 cells cell NNS cord-010119-t1x9gknd 13003 9 in in IN cord-010119-t1x9gknd 13003 10 the the DT cord-010119-t1x9gknd 13003 11 lab lab NN cord-010119-t1x9gknd 13003 12 to to TO cord-010119-t1x9gknd 13003 13 place place VB cord-010119-t1x9gknd 13003 14 samples sample NNS cord-010119-t1x9gknd 13003 15 based base VBN cord-010119-t1x9gknd 13003 16 on on IN cord-010119-t1x9gknd 13003 17 their -PRON- PRP$ cord-010119-t1x9gknd 13003 18 phase phase NN cord-010119-t1x9gknd 13003 19 / / SYM cord-010119-t1x9gknd 13003 20 stage stage NN cord-010119-t1x9gknd 13003 21 of of IN cord-010119-t1x9gknd 13003 22 testing testing NN cord-010119-t1x9gknd 13003 23 . . . cord-010119-t1x9gknd 13004 1 After after IN cord-010119-t1x9gknd 13004 2 counter counter NN cord-010119-t1x9gknd 13004 3 measures measure NNS cord-010119-t1x9gknd 13004 4 were be VBD cord-010119-t1x9gknd 13004 5 implemented implement VBN cord-010119-t1x9gknd 13004 6 , , , cord-010119-t1x9gknd 13004 7 the the DT cord-010119-t1x9gknd 13004 8 number number NN cord-010119-t1x9gknd 13004 9 of of IN cord-010119-t1x9gknd 13004 10 exceptions exception NNS cord-010119-t1x9gknd 13004 11 decreased decrease VBD cord-010119-t1x9gknd 13004 12 from from IN cord-010119-t1x9gknd 13004 13 17.4 17.4 CD cord-010119-t1x9gknd 13004 14 per per IN cord-010119-t1x9gknd 13004 15 day day NN cord-010119-t1x9gknd 13004 16 or or CC cord-010119-t1x9gknd 13004 17 10,370 10,370 CD cord-010119-t1x9gknd 13004 18 DPMO DPMO NNS cord-010119-t1x9gknd 13004 19 to to IN cord-010119-t1x9gknd 13004 20 6.3 6.3 CD cord-010119-t1x9gknd 13004 21 per per IN cord-010119-t1x9gknd 13004 22 day day NN cord-010119-t1x9gknd 13004 23 or or CC cord-010119-t1x9gknd 13004 24 3,539 3,539 CD cord-010119-t1x9gknd 13004 25 DPMO DPMO NNS cord-010119-t1x9gknd 13004 26 . . . cord-010119-t1x9gknd 13005 1 This this DT cord-010119-t1x9gknd 13005 2 is be VBZ cord-010119-t1x9gknd 13005 3 a a DT cord-010119-t1x9gknd 13005 4 statistically statistically RB cord-010119-t1x9gknd 13005 5 significant significant JJ cord-010119-t1x9gknd 13005 6 difference difference NN cord-010119-t1x9gknd 13005 7 since since IN cord-010119-t1x9gknd 13005 8 the the DT cord-010119-t1x9gknd 13005 9 p p NN cord-010119-t1x9gknd 13005 10 - - HYPH cord-010119-t1x9gknd 13005 11 Value value NN cord-010119-t1x9gknd 13005 12 calculated calculate VBN cord-010119-t1x9gknd 13005 13 was be VBD cord-010119-t1x9gknd 13005 14 0.002 0.002 CD cord-010119-t1x9gknd 13005 15 . . . cord-010119-t1x9gknd 13006 1 Conclusion conclusion NN cord-010119-t1x9gknd 13006 2 : : : cord-010119-t1x9gknd 13007 1 A a DT cord-010119-t1x9gknd 13007 2 lean lean JJ cord-010119-t1x9gknd 13007 3 Six six CD cord-010119-t1x9gknd 13007 4 Sigma Sigma NNP cord-010119-t1x9gknd 13007 5 approach approach NN cord-010119-t1x9gknd 13007 6 for for IN cord-010119-t1x9gknd 13007 7 process process NN cord-010119-t1x9gknd 13007 8 improvement improvement NN cord-010119-t1x9gknd 13007 9 was be VBD cord-010119-t1x9gknd 13007 10 utilized utilize VBN cord-010119-t1x9gknd 13007 11 to to TO cord-010119-t1x9gknd 13007 12 identify identify VB cord-010119-t1x9gknd 13007 13 root root NN cord-010119-t1x9gknd 13007 14 causes cause NNS cord-010119-t1x9gknd 13007 15 and and CC cord-010119-t1x9gknd 13007 16 develop develop VB cord-010119-t1x9gknd 13007 17 countermeasures countermeasure NNS cord-010119-t1x9gknd 13007 18 in in IN cord-010119-t1x9gknd 13007 19 order order NN cord-010119-t1x9gknd 13007 20 to to TO cord-010119-t1x9gknd 13007 21 decrease decrease VB cord-010119-t1x9gknd 13007 22 the the DT cord-010119-t1x9gknd 13007 23 number number NN cord-010119-t1x9gknd 13007 24 of of IN cord-010119-t1x9gknd 13007 25 exceptions exception NNS cord-010119-t1x9gknd 13007 26 related relate VBN cord-010119-t1x9gknd 13007 27 to to IN cord-010119-t1x9gknd 13007 28 the the DT cord-010119-t1x9gknd 13007 29 testing testing NN cord-010119-t1x9gknd 13007 30 of of IN cord-010119-t1x9gknd 13007 31 whole whole JJ cord-010119-t1x9gknd 13007 32 blood blood NN cord-010119-t1x9gknd 13007 33 samples sample NNS cord-010119-t1x9gknd 13007 34 in in IN cord-010119-t1x9gknd 13007 35 the the DT cord-010119-t1x9gknd 13007 36 laboratory laboratory NN cord-010119-t1x9gknd 13007 37 . . . cord-010119-t1x9gknd 13008 1 This this DT cord-010119-t1x9gknd 13008 2 approach approach NN cord-010119-t1x9gknd 13008 3 and and CC cord-010119-t1x9gknd 13008 4 counter counter NN cord-010119-t1x9gknd 13008 5 measures measure NNS cord-010119-t1x9gknd 13008 6 statistically statistically RB cord-010119-t1x9gknd 13008 7 significantly significantly RB cord-010119-t1x9gknd 13008 8 decreased decrease VBD cord-010119-t1x9gknd 13008 9 the the DT cord-010119-t1x9gknd 13008 10 number number NN cord-010119-t1x9gknd 13008 11 of of IN cord-010119-t1x9gknd 13008 12 exceptions exception NNS cord-010119-t1x9gknd 13008 13 seen see VBN cord-010119-t1x9gknd 13008 14 in in IN cord-010119-t1x9gknd 13008 15 the the DT cord-010119-t1x9gknd 13008 16 whole whole JJ cord-010119-t1x9gknd 13008 17 blood blood NN cord-010119-t1x9gknd 13008 18 testing testing NN cord-010119-t1x9gknd 13008 19 process process NN cord-010119-t1x9gknd 13008 20 . . . cord-010119-t1x9gknd 13009 1 Background Background NNP cord-010119-t1x9gknd 13009 2 / / SYM cord-010119-t1x9gknd 13009 3 Case Case NNP cord-010119-t1x9gknd 13009 4 Studies Studies NNPS cord-010119-t1x9gknd 13009 5 : : : cord-010119-t1x9gknd 13010 1 Our -PRON- PRP$ cord-010119-t1x9gknd 13010 2 Blood Blood NNP cord-010119-t1x9gknd 13010 3 Bank Bank NNP cord-010119-t1x9gknd 13010 4 processes process VBZ cord-010119-t1x9gknd 13010 5 approximately approximately RB cord-010119-t1x9gknd 13010 6 4,400 4,400 CD cord-010119-t1x9gknd 13010 7 specimens specimen NNS cord-010119-t1x9gknd 13010 8 per per IN cord-010119-t1x9gknd 13010 9 month month NN cord-010119-t1x9gknd 13010 10 . . . cord-010119-t1x9gknd 13011 1 Since since IN cord-010119-t1x9gknd 13011 2 1998 1998 CD cord-010119-t1x9gknd 13011 3 , , , cord-010119-t1x9gknd 13011 4 the the DT cord-010119-t1x9gknd 13011 5 requirement requirement NN cord-010119-t1x9gknd 13011 6 of of IN cord-010119-t1x9gknd 13011 7 having have VBG cord-010119-t1x9gknd 13011 8 a a DT cord-010119-t1x9gknd 13011 9 second second JJ cord-010119-t1x9gknd 13011 10 blood blood NN cord-010119-t1x9gknd 13011 11 type type NN cord-010119-t1x9gknd 13011 12 on on IN cord-010119-t1x9gknd 13011 13 record record NN cord-010119-t1x9gknd 13011 14 was be VBD cord-010119-t1x9gknd 13011 15 met meet VBN cord-010119-t1x9gknd 13011 16 by:1 by:1 NNP cord-010119-t1x9gknd 13011 17 . . . cord-010119-t1x9gknd 13012 1 Utilizing utilize VBG cord-010119-t1x9gknd 13012 2 the the DT cord-010119-t1x9gknd 13012 3 historical historical JJ cord-010119-t1x9gknd 13012 4 blood blood NN cord-010119-t1x9gknd 13012 5 type type NN cord-010119-t1x9gknd 13012 6 and and CC cord-010119-t1x9gknd 13012 7 the the DT cord-010119-t1x9gknd 13012 8 current current JJ cord-010119-t1x9gknd 13012 9 specimen specimen NN cord-010119-t1x9gknd 13012 10 , , , cord-010119-t1x9gknd 13012 11 OR or CC cord-010119-t1x9gknd 13012 12 2 2 CD cord-010119-t1x9gknd 13012 13 . . . cord-010119-t1x9gknd 13013 1 Having have VBG cord-010119-t1x9gknd 13013 2 second second JJ cord-010119-t1x9gknd 13013 3 type type NN cord-010119-t1x9gknd 13013 4 performed perform VBN cord-010119-t1x9gknd 13013 5 on on IN cord-010119-t1x9gknd 13013 6 same same JJ cord-010119-t1x9gknd 13013 7 specimen specimen NN cord-010119-t1x9gknd 13013 8 by by IN cord-010119-t1x9gknd 13013 9 different different JJ cord-010119-t1x9gknd 13013 10 technologist technologist NN cord-010119-t1x9gknd 13013 11 , , , cord-010119-t1x9gknd 13013 12 AND and CC cord-010119-t1x9gknd 13013 13 3 3 CD cord-010119-t1x9gknd 13013 14 . . . cord-010119-t1x9gknd 13014 1 Each each DT cord-010119-t1x9gknd 13014 2 type type NN cord-010119-t1x9gknd 13014 3 and and CC cord-010119-t1x9gknd 13014 4 screen screen NN cord-010119-t1x9gknd 13014 5 specimen specimen NN cord-010119-t1x9gknd 13014 6 signed sign VBN cord-010119-t1x9gknd 13014 7 by by IN cord-010119-t1x9gknd 13014 8 2 2 CD cord-010119-t1x9gknd 13014 9 staff staff NN cord-010119-t1x9gknd 13014 10 , , , cord-010119-t1x9gknd 13014 11 one one CD cord-010119-t1x9gknd 13014 12 being be VBG cord-010119-t1x9gknd 13014 13 a a DT cord-010119-t1x9gknd 13014 14 licensed licensed JJ cord-010119-t1x9gknd 13014 15 practitioner practitioner NN cord-010119-t1x9gknd 13014 16 attesting attest VBG cord-010119-t1x9gknd 13014 17 the the DT cord-010119-t1x9gknd 13014 18 identification identification NN cord-010119-t1x9gknd 13014 19 of of IN cord-010119-t1x9gknd 13014 20 the the DT cord-010119-t1x9gknd 13014 21 patient patient NN cord-010119-t1x9gknd 13014 22 was be VBD cord-010119-t1x9gknd 13014 23 done do VBN cord-010119-t1x9gknd 13014 24 accurately accurately RB cord-010119-t1x9gknd 13014 25 at at IN cord-010119-t1x9gknd 13014 26 bedside bedside NN cord-010119-t1x9gknd 13014 27 . . . cord-010119-t1x9gknd 13015 1 To to TO cord-010119-t1x9gknd 13015 2 comply comply VB cord-010119-t1x9gknd 13015 3 with with IN cord-010119-t1x9gknd 13015 4 the the DT cord-010119-t1x9gknd 13015 5 AABB AABB NNP cord-010119-t1x9gknd 13015 6 Standards standard NNS cord-010119-t1x9gknd 13015 7 29 29 CD cord-010119-t1x9gknd 13015 8 th th XX cord-010119-t1x9gknd 13015 9 edition edition NN cord-010119-t1x9gknd 13015 10 , , , cord-010119-t1x9gknd 13015 11 # # $ cord-010119-t1x9gknd 13015 12 5.16.2.2 5.16.2.2 CD cord-010119-t1x9gknd 13015 13 a a DT cord-010119-t1x9gknd 13015 14 decision decision NN cord-010119-t1x9gknd 13015 15 was be VBD cord-010119-t1x9gknd 13015 16 made make VBN cord-010119-t1x9gknd 13015 17 to to TO cord-010119-t1x9gknd 13015 18 change change VB cord-010119-t1x9gknd 13015 19 our -PRON- PRP$ cord-010119-t1x9gknd 13015 20 practices practice NNS cord-010119-t1x9gknd 13015 21 . . . cord-010119-t1x9gknd 13016 1 We -PRON- PRP cord-010119-t1x9gknd 13016 2 considered consider VBD cord-010119-t1x9gknd 13016 3 challenges challenge NNS cord-010119-t1x9gknd 13016 4 encountered encounter VBN cord-010119-t1x9gknd 13016 5 at at IN cord-010119-t1x9gknd 13016 6 other other JJ cord-010119-t1x9gknd 13016 7 hospitals hospital NNS cord-010119-t1x9gknd 13016 8 and and CC cord-010119-t1x9gknd 13016 9 collaborated collaborate VBN cord-010119-t1x9gknd 13016 10 with with IN cord-010119-t1x9gknd 13016 11 nursing nursing NN cord-010119-t1x9gknd 13016 12 and and CC cord-010119-t1x9gknd 13016 13 IT it PRP cord-010119-t1x9gknd 13016 14 to to TO cord-010119-t1x9gknd 13016 15 create create VB cord-010119-t1x9gknd 13016 16 a a DT cord-010119-t1x9gknd 13016 17 streamlined streamlined JJ cord-010119-t1x9gknd 13016 18 and and CC cord-010119-t1x9gknd 13016 19 safe safe JJ cord-010119-t1x9gknd 13016 20 process process NN cord-010119-t1x9gknd 13016 21 . . . cord-010119-t1x9gknd 13017 1 In in IN cord-010119-t1x9gknd 13017 2 April April NNP cord-010119-t1x9gknd 13017 3 2016 2016 CD cord-010119-t1x9gknd 13017 4 , , , cord-010119-t1x9gknd 13017 5 the the DT cord-010119-t1x9gknd 13017 6 second second JJ cord-010119-t1x9gknd 13017 7 specimen specimen NN cord-010119-t1x9gknd 13017 8 procedure procedure NN cord-010119-t1x9gknd 13017 9 was be VBD cord-010119-t1x9gknd 13017 10 implemented implement VBN cord-010119-t1x9gknd 13017 11 addressing address VBG cord-010119-t1x9gknd 13017 12 the the DT cord-010119-t1x9gknd 13017 13 following follow VBG cord-010119-t1x9gknd 13017 14 : : : cord-010119-t1x9gknd 13017 15 II II NNP cord-010119-t1x9gknd 13017 16 . . . cord-010119-t1x9gknd 13018 1 Extensive extensive JJ cord-010119-t1x9gknd 13018 2 education education NN cord-010119-t1x9gknd 13018 3 was be VBD cord-010119-t1x9gknd 13018 4 provided provide VBN cord-010119-t1x9gknd 13018 5 to to IN cord-010119-t1x9gknd 13018 6 all all DT cord-010119-t1x9gknd 13018 7 involved involve VBN cord-010119-t1x9gknd 13018 8 in in IN cord-010119-t1x9gknd 13018 9 the the DT cord-010119-t1x9gknd 13018 10 process process NN cord-010119-t1x9gknd 13018 11 prior prior RB cord-010119-t1x9gknd 13018 12 to to IN cord-010119-t1x9gknd 13018 13 implementation implementation NN cord-010119-t1x9gknd 13018 14 including include VBG cord-010119-t1x9gknd 13018 15 a a DT cord-010119-t1x9gknd 13018 16 learning learning NN cord-010119-t1x9gknd 13018 17 module module NN cord-010119-t1x9gknd 13018 18 prepared prepare VBN cord-010119-t1x9gknd 13018 19 by by IN cord-010119-t1x9gknd 13018 20 blood blood NN cord-010119-t1x9gknd 13018 21 bank bank NN cord-010119-t1x9gknd 13018 22 and and CC cord-010119-t1x9gknd 13018 23 nursing nursing NN cord-010119-t1x9gknd 13018 24 collaboratively collaboratively RB cord-010119-t1x9gknd 13018 25 . . . cord-010119-t1x9gknd 13019 1 Results result NNS cord-010119-t1x9gknd 13019 2 / / SYM cord-010119-t1x9gknd 13019 3 Finding:1 Finding:1 NNP cord-010119-t1x9gknd 13019 4 . . . cord-010119-t1x9gknd 13020 1 There there EX cord-010119-t1x9gknd 13020 2 was be VBD cord-010119-t1x9gknd 13020 3 a a DT cord-010119-t1x9gknd 13020 4 minor minor JJ cord-010119-t1x9gknd 13020 5 adjustment adjustment NN cord-010119-t1x9gknd 13020 6 period period NN cord-010119-t1x9gknd 13020 7 with with IN cord-010119-t1x9gknd 13020 8 more more JJR cord-010119-t1x9gknd 13020 9 phone phone NN cord-010119-t1x9gknd 13020 10 calls call NNS cord-010119-t1x9gknd 13020 11 made make VBN cord-010119-t1x9gknd 13020 12 to to IN cord-010119-t1x9gknd 13020 13 blood blood NN cord-010119-t1x9gknd 13020 14 bank bank NN cord-010119-t1x9gknd 13020 15 to to TO cord-010119-t1x9gknd 13020 16 explain explain VB cord-010119-t1x9gknd 13020 17 the the DT cord-010119-t1x9gknd 13020 18 process process NN cord-010119-t1x9gknd 13020 19 . . . cord-010119-t1x9gknd 13021 1 2 2 LS cord-010119-t1x9gknd 13021 2 . . . cord-010119-t1x9gknd 13022 1 There there EX cord-010119-t1x9gknd 13022 2 was be VBD cord-010119-t1x9gknd 13022 3 minimal minimal JJ cord-010119-t1x9gknd 13022 4 impact impact NN cord-010119-t1x9gknd 13022 5 on on IN cord-010119-t1x9gknd 13022 6 turn turn NN cord-010119-t1x9gknd 13022 7 around around RP cord-010119-t1x9gknd 13022 8 times time NNS cord-010119-t1x9gknd 13022 9 for for IN cord-010119-t1x9gknd 13022 10 release release NN cord-010119-t1x9gknd 13022 11 of of IN cord-010119-t1x9gknd 13022 12 components component NNS cord-010119-t1x9gknd 13022 13 . . . cord-010119-t1x9gknd 13023 1 3 3 LS cord-010119-t1x9gknd 13023 2 . . . cord-010119-t1x9gknd 13024 1 ABORh ABORh NNS cord-010119-t1x9gknd 13024 2 retype retype VBP cord-010119-t1x9gknd 13024 3 workload workload NN cord-010119-t1x9gknd 13024 4 decreased decrease VBD cord-010119-t1x9gknd 13024 5 from from IN cord-010119-t1x9gknd 13024 6 1500 1500 CD cord-010119-t1x9gknd 13024 7 to to IN cord-010119-t1x9gknd 13024 8 950 950 CD cord-010119-t1x9gknd 13024 9 ( ( -LRB- cord-010119-t1x9gknd 13024 10 35 35 CD cord-010119-t1x9gknd 13024 11 % % NN cord-010119-t1x9gknd 13024 12 to to TO cord-010119-t1x9gknd 13024 13 20 20 CD cord-010119-t1x9gknd 13024 14 % % NN cord-010119-t1x9gknd 13024 15 of of IN cord-010119-t1x9gknd 13024 16 T&S T&S NNP cord-010119-t1x9gknd 13024 17 volume volume NN cord-010119-t1x9gknd 13024 18 ) ) -RRB- cord-010119-t1x9gknd 13024 19 per per IN cord-010119-t1x9gknd 13024 20 month month NN cord-010119-t1x9gknd 13024 21 . . . cord-010119-t1x9gknd 13025 1 4 4 LS cord-010119-t1x9gknd 13025 2 . . . cord-010119-t1x9gknd 13026 1 Unnecessary unnecessary JJ cord-010119-t1x9gknd 13026 2 blood blood NN cord-010119-t1x9gknd 13026 3 draws draw VBZ cord-010119-t1x9gknd 13026 4 minimized minimize VBN cord-010119-t1x9gknd 13026 5 , , , cord-010119-t1x9gknd 13026 6 improving improve VBG cord-010119-t1x9gknd 13026 7 patient patient JJ cord-010119-t1x9gknd 13026 8 experience experience NN cord-010119-t1x9gknd 13026 9 . . . cord-010119-t1x9gknd 13027 1 5 5 LS cord-010119-t1x9gknd 13027 2 . . . cord-010119-t1x9gknd 13028 1 No no DT cord-010119-t1x9gknd 13028 2 emergency emergency NN cord-010119-t1x9gknd 13028 3 release release NN cord-010119-t1x9gknd 13028 4 requests request NNS cord-010119-t1x9gknd 13028 5 due due JJ cord-010119-t1x9gknd 13028 6 to to IN cord-010119-t1x9gknd 13028 7 absence absence NN cord-010119-t1x9gknd 13028 8 of of IN cord-010119-t1x9gknd 13028 9 a a DT cord-010119-t1x9gknd 13028 10 second second JJ cord-010119-t1x9gknd 13028 11 specimen specimen NN cord-010119-t1x9gknd 13028 12 . . . cord-010119-t1x9gknd 13029 1 The the DT cord-010119-t1x9gknd 13029 2 second second JJ cord-010119-t1x9gknd 13029 3 specimen specimen NN cord-010119-t1x9gknd 13029 4 process process NN cord-010119-t1x9gknd 13029 5 with with IN cord-010119-t1x9gknd 13029 6 the the DT cord-010119-t1x9gknd 13029 7 conditional conditional JJ cord-010119-t1x9gknd 13029 8 order order NN cord-010119-t1x9gknd 13029 9 has have VBZ cord-010119-t1x9gknd 13029 10 been be VBN cord-010119-t1x9gknd 13029 11 beneficial beneficial JJ cord-010119-t1x9gknd 13029 12 to to IN cord-010119-t1x9gknd 13029 13 our -PRON- PRP$ cord-010119-t1x9gknd 13029 14 blood blood NN cord-010119-t1x9gknd 13029 15 bank bank NN cord-010119-t1x9gknd 13029 16 as as RB cord-010119-t1x9gknd 13029 17 well well RB cord-010119-t1x9gknd 13029 18 as as IN cord-010119-t1x9gknd 13029 19 patient patient JJ cord-010119-t1x9gknd 13029 20 care care NN cord-010119-t1x9gknd 13029 21 services service NNS cord-010119-t1x9gknd 13029 22 . . . cord-010119-t1x9gknd 13030 1 Overall overall JJ cord-010119-t1x9gknd 13030 2 feedback feedback NN cord-010119-t1x9gknd 13030 3 from from IN cord-010119-t1x9gknd 13030 4 staff staff NN cord-010119-t1x9gknd 13030 5 on on IN cord-010119-t1x9gknd 13030 6 the the DT cord-010119-t1x9gknd 13030 7 process process NN cord-010119-t1x9gknd 13030 8 has have VBZ cord-010119-t1x9gknd 13030 9 been be VBN cord-010119-t1x9gknd 13030 10 positive positive JJ cord-010119-t1x9gknd 13030 11 . . . cord-010119-t1x9gknd 13031 1 Our -PRON- PRP$ cord-010119-t1x9gknd 13031 2 workload workload NN cord-010119-t1x9gknd 13031 3 has have VBZ cord-010119-t1x9gknd 13031 4 decreased decrease VBN cord-010119-t1x9gknd 13031 5 which which WDT cord-010119-t1x9gknd 13031 6 results result NNS cord-010119-t1x9gknd 13031 7 in in IN cord-010119-t1x9gknd 13031 8 cost cost NN cord-010119-t1x9gknd 13031 9 savings saving NNS cord-010119-t1x9gknd 13031 10 and and CC cord-010119-t1x9gknd 13031 11 increased increase VBN cord-010119-t1x9gknd 13031 12 efficiency efficiency NN cord-010119-t1x9gknd 13031 13 allowing allow VBG cord-010119-t1x9gknd 13031 14 us -PRON- PRP cord-010119-t1x9gknd 13031 15 to to TO cord-010119-t1x9gknd 13031 16 devote devote VB cord-010119-t1x9gknd 13031 17 more more JJR cord-010119-t1x9gknd 13031 18 resources resource NNS cord-010119-t1x9gknd 13031 19 to to IN cord-010119-t1x9gknd 13031 20 the the DT cord-010119-t1x9gknd 13031 21 growing grow VBG cord-010119-t1x9gknd 13031 22 services service NNS cord-010119-t1x9gknd 13031 23 at at IN cord-010119-t1x9gknd 13031 24 our -PRON- PRP$ cord-010119-t1x9gknd 13031 25 institution institution NN cord-010119-t1x9gknd 13031 26 . . . cord-010119-t1x9gknd 13032 1 Background Background NNP cord-010119-t1x9gknd 13032 2 / / SYM cord-010119-t1x9gknd 13032 3 Case Case NNP cord-010119-t1x9gknd 13032 4 Studies Studies NNPS cord-010119-t1x9gknd 13032 5 : : : cord-010119-t1x9gknd 13032 6 The the DT cord-010119-t1x9gknd 13032 7 hazards hazard NNS cord-010119-t1x9gknd 13032 8 of of IN cord-010119-t1x9gknd 13032 9 transfusion transfusion NN cord-010119-t1x9gknd 13032 10 are be VBP cord-010119-t1x9gknd 13032 11 well well RB cord-010119-t1x9gknd 13032 12 recognized recognize VBN cord-010119-t1x9gknd 13032 13 and and CC cord-010119-t1x9gknd 13032 14 in in IN cord-010119-t1x9gknd 13032 15 certain certain JJ cord-010119-t1x9gknd 13032 16 cases case NNS cord-010119-t1x9gknd 13032 17 restrictive restrictive JJ cord-010119-t1x9gknd 13032 18 transfusion transfusion NN cord-010119-t1x9gknd 13032 19 strategies strategy NNS cord-010119-t1x9gknd 13032 20 compared compare VBN cord-010119-t1x9gknd 13032 21 to to IN cord-010119-t1x9gknd 13032 22 liberal liberal JJ cord-010119-t1x9gknd 13032 23 transfusion transfusion NN cord-010119-t1x9gknd 13032 24 strategies strategy NNS cord-010119-t1x9gknd 13032 25 may may MD cord-010119-t1x9gknd 13032 26 be be VB cord-010119-t1x9gknd 13032 27 associated associate VBN cord-010119-t1x9gknd 13032 28 with with IN cord-010119-t1x9gknd 13032 29 better well JJR cord-010119-t1x9gknd 13032 30 clinical clinical JJ cord-010119-t1x9gknd 13032 31 outcome outcome NN cord-010119-t1x9gknd 13032 32 . . . cord-010119-t1x9gknd 13033 1 With with IN cord-010119-t1x9gknd 13033 2 this this DT cord-010119-t1x9gknd 13033 3 in in IN cord-010119-t1x9gknd 13033 4 mind mind NN cord-010119-t1x9gknd 13033 5 , , , cord-010119-t1x9gknd 13033 6 AABB AABB NNP cord-010119-t1x9gknd 13033 7 and and CC cord-010119-t1x9gknd 13033 8 others other NNS cord-010119-t1x9gknd 13033 9 published publish VBD cord-010119-t1x9gknd 13033 10 guidelines guideline NNS cord-010119-t1x9gknd 13033 11 for for IN cord-010119-t1x9gknd 13033 12 transfusion transfusion NN cord-010119-t1x9gknd 13033 13 , , , cord-010119-t1x9gknd 13033 14 but but CC cord-010119-t1x9gknd 13033 15 even even RB cord-010119-t1x9gknd 13033 16 with with IN cord-010119-t1x9gknd 13033 17 guidelines guideline NNS cord-010119-t1x9gknd 13033 18 in in IN cord-010119-t1x9gknd 13033 19 place place NN cord-010119-t1x9gknd 13033 20 , , , cord-010119-t1x9gknd 13033 21 rate rate NN cord-010119-t1x9gknd 13033 22 of of IN cord-010119-t1x9gknd 13033 23 inappropriate inappropriate JJ cord-010119-t1x9gknd 13033 24 blood blood NN cord-010119-t1x9gknd 13033 25 transfusions transfusion NNS cord-010119-t1x9gknd 13033 26 is be VBZ cord-010119-t1x9gknd 13033 27 reported report VBN cord-010119-t1x9gknd 13033 28 to to TO cord-010119-t1x9gknd 13033 29 be be VB cord-010119-t1x9gknd 13033 30 as as RB cord-010119-t1x9gknd 13033 31 high high JJ cord-010119-t1x9gknd 13033 32 as as IN cord-010119-t1x9gknd 13033 33 15 15 CD cord-010119-t1x9gknd 13033 34 to to TO cord-010119-t1x9gknd 13033 35 48 48 CD cord-010119-t1x9gknd 13033 36 % % NN cord-010119-t1x9gknd 13033 37 . . . cord-010119-t1x9gknd 13034 1 Computerized Computerized NNP cord-010119-t1x9gknd 13034 2 Provider provider NN cord-010119-t1x9gknd 13034 3 Order order NN cord-010119-t1x9gknd 13034 4 Entry Entry NNP cord-010119-t1x9gknd 13034 5 ( ( -LRB- cord-010119-t1x9gknd 13034 6 CPOE CPOE NNP cord-010119-t1x9gknd 13034 7 ) ) -RRB- cord-010119-t1x9gknd 13034 8 , , , cord-010119-t1x9gknd 13034 9 is be VBZ cord-010119-t1x9gknd 13034 10 a a DT cord-010119-t1x9gknd 13034 11 process process NN cord-010119-t1x9gknd 13034 12 of of IN cord-010119-t1x9gknd 13034 13 electronic electronic JJ cord-010119-t1x9gknd 13034 14 medical medical JJ cord-010119-t1x9gknd 13034 15 order order NN cord-010119-t1x9gknd 13034 16 entry entry NN cord-010119-t1x9gknd 13034 17 for for IN cord-010119-t1x9gknd 13034 18 medical medical JJ cord-010119-t1x9gknd 13034 19 practitioners practitioner NNS cord-010119-t1x9gknd 13034 20 with with IN cord-010119-t1x9gknd 13034 21 instructions instruction NNS cord-010119-t1x9gknd 13034 22 and and CC cord-010119-t1x9gknd 13034 23 guidelines guideline NNS cord-010119-t1x9gknd 13034 24 for for IN cord-010119-t1x9gknd 13034 25 treatment treatment NN cord-010119-t1x9gknd 13034 26 . . . cord-010119-t1x9gknd 13035 1 The the DT cord-010119-t1x9gknd 13035 2 objective objective NN cord-010119-t1x9gknd 13035 3 of of IN cord-010119-t1x9gknd 13035 4 this this DT cord-010119-t1x9gknd 13035 5 study study NN cord-010119-t1x9gknd 13035 6 was be VBD cord-010119-t1x9gknd 13035 7 determination determination NN cord-010119-t1x9gknd 13035 8 of of IN cord-010119-t1x9gknd 13035 9 transfusion transfusion NN cord-010119-t1x9gknd 13035 10 practice practice NN cord-010119-t1x9gknd 13035 11 quality quality NN cord-010119-t1x9gknd 13035 12 by by IN cord-010119-t1x9gknd 13035 13 thorough thorough JJ cord-010119-t1x9gknd 13035 14 chart chart NN cord-010119-t1x9gknd 13035 15 and and CC cord-010119-t1x9gknd 13035 16 electronic electronic JJ cord-010119-t1x9gknd 13035 17 medical medical JJ cord-010119-t1x9gknd 13035 18 record record NN cord-010119-t1x9gknd 13035 19 review review NN cord-010119-t1x9gknd 13035 20 , , , cord-010119-t1x9gknd 13035 21 with with IN cord-010119-t1x9gknd 13035 22 measures measure NNS cord-010119-t1x9gknd 13035 23 in in IN cord-010119-t1x9gknd 13035 24 place place NN cord-010119-t1x9gknd 13035 25 to to TO cord-010119-t1x9gknd 13035 26 avoid avoid VB cord-010119-t1x9gknd 13035 27 inappropriate inappropriate JJ cord-010119-t1x9gknd 13035 28 transfusion transfusion NN cord-010119-t1x9gknd 13035 29 . . . cord-010119-t1x9gknd 13036 1 Additionally additionally RB cord-010119-t1x9gknd 13036 2 , , , cord-010119-t1x9gknd 13036 3 factors factor NNS cord-010119-t1x9gknd 13036 4 associated associate VBN cord-010119-t1x9gknd 13036 5 with with IN cord-010119-t1x9gknd 13036 6 inappropriate inappropriate JJ cord-010119-t1x9gknd 13036 7 transfusion transfusion NN cord-010119-t1x9gknd 13036 8 were be VBD cord-010119-t1x9gknd 13036 9 examined examine VBN cord-010119-t1x9gknd 13036 10 . . . cord-010119-t1x9gknd 13037 1 Study Study NNP cord-010119-t1x9gknd 13037 2 Design Design NNP cord-010119-t1x9gknd 13037 3 / / SYM cord-010119-t1x9gknd 13037 4 Method method NN cord-010119-t1x9gknd 13037 5 : : : cord-010119-t1x9gknd 13038 1 In in IN cord-010119-t1x9gknd 13038 2 our -PRON- PRP$ cord-010119-t1x9gknd 13038 3 926 926 CD cord-010119-t1x9gknd 13038 4 bed bed NN cord-010119-t1x9gknd 13038 5 hospital hospital NN cord-010119-t1x9gknd 13038 6 , , , cord-010119-t1x9gknd 13038 7 a a DT cord-010119-t1x9gknd 13038 8 retrospective retrospective JJ cord-010119-t1x9gknd 13038 9 chart chart NN cord-010119-t1x9gknd 13038 10 review review NN cord-010119-t1x9gknd 13038 11 was be VBD cord-010119-t1x9gknd 13038 12 performed perform VBN cord-010119-t1x9gknd 13038 13 ( ( -LRB- cord-010119-t1x9gknd 13038 14 07/01/15 07/01/15 CD cord-010119-t1x9gknd 13038 15 - - HYPH cord-010119-t1x9gknd 13038 16 12/31/15 12/31/15 CD cord-010119-t1x9gknd 13038 17 ) ) -RRB- cord-010119-t1x9gknd 13038 18 on on IN cord-010119-t1x9gknd 13038 19 hospitalized hospitalize VBN cord-010119-t1x9gknd 13038 20 internal internal JJ cord-010119-t1x9gknd 13038 21 medicine medicine NN cord-010119-t1x9gknd 13038 22 patients patient NNS cord-010119-t1x9gknd 13038 23 . . . cord-010119-t1x9gknd 13039 1 CPOE CPOE NNP cord-010119-t1x9gknd 13039 2 with with IN cord-010119-t1x9gknd 13039 3 hospital hospital NN cord-010119-t1x9gknd 13039 4 guidelines guideline NNS cord-010119-t1x9gknd 13039 5 for for IN cord-010119-t1x9gknd 13039 6 RBC RBC NNP cord-010119-t1x9gknd 13039 7 transfusions transfusion NNS cord-010119-t1x9gknd 13039 8 were be VBD cord-010119-t1x9gknd 13039 9 in in IN cord-010119-t1x9gknd 13039 10 place place NN cord-010119-t1x9gknd 13039 11 . . . cord-010119-t1x9gknd 13040 1 Transfusion transfusion NN cord-010119-t1x9gknd 13040 2 thresholds threshold NNS cord-010119-t1x9gknd 13040 3 in in IN cord-010119-t1x9gknd 13040 4 different different JJ cord-010119-t1x9gknd 13040 5 clinical clinical JJ cord-010119-t1x9gknd 13040 6 settings setting NNS cord-010119-t1x9gknd 13040 7 were be VBD cord-010119-t1x9gknd 13040 8 determined determine VBN cord-010119-t1x9gknd 13040 9 by by IN cord-010119-t1x9gknd 13040 10 a a DT cord-010119-t1x9gknd 13040 11 thorough thorough JJ cord-010119-t1x9gknd 13040 12 literature literature NN cord-010119-t1x9gknd 13040 13 review review NN cord-010119-t1x9gknd 13040 14 of of IN cord-010119-t1x9gknd 13040 15 studies study NNS cord-010119-t1x9gknd 13040 16 analyzing analyze VBG cord-010119-t1x9gknd 13040 17 restrictive restrictive JJ cord-010119-t1x9gknd 13040 18 transfusion transfusion NN cord-010119-t1x9gknd 13040 19 strategy strategy NN cord-010119-t1x9gknd 13040 20 , , , cord-010119-t1x9gknd 13040 21 and and CC cord-010119-t1x9gknd 13040 22 transfusion transfusion NN cord-010119-t1x9gknd 13040 23 guidelines guideline NNS cord-010119-t1x9gknd 13040 24 by by IN cord-010119-t1x9gknd 13040 25 various various JJ cord-010119-t1x9gknd 13040 26 medical medical JJ cord-010119-t1x9gknd 13040 27 societies society NNS cord-010119-t1x9gknd 13040 28 . . . cord-010119-t1x9gknd 13041 1 Charts chart NNS cord-010119-t1x9gknd 13041 2 for for IN cord-010119-t1x9gknd 13041 3 Background Background NNP cord-010119-t1x9gknd 13041 4 / / SYM cord-010119-t1x9gknd 13041 5 Case Case NNP cord-010119-t1x9gknd 13041 6 Studies Studies NNPS cord-010119-t1x9gknd 13041 7 : : : cord-010119-t1x9gknd 13041 8 Our -PRON- PRP$ cord-010119-t1x9gknd 13041 9 Midwestern Midwestern NNP cord-010119-t1x9gknd 13041 10 University University NNP cord-010119-t1x9gknd 13041 11 - - HYPH cord-010119-t1x9gknd 13041 12 Based Based NNP cord-010119-t1x9gknd 13041 13 Transfusion Transfusion NNP cord-010119-t1x9gknd 13041 14 Service Service NNP cord-010119-t1x9gknd 13041 15 ( ( -LRB- cord-010119-t1x9gknd 13041 16 TS TS NNP cord-010119-t1x9gknd 13041 17 ) ) -RRB- cord-010119-t1x9gknd 13041 18 evaluated evaluate VBD cord-010119-t1x9gknd 13041 19 the the DT cord-010119-t1x9gknd 13041 20 appropriateness appropriateness NN cord-010119-t1x9gknd 13041 21 the the DT cord-010119-t1x9gknd 13041 22 automated automate VBN cord-010119-t1x9gknd 13041 23 platform platform NN cord-010119-t1x9gknd 13041 24 VISION vision NN cord-010119-t1x9gknd 13041 25 ( ( -LRB- cord-010119-t1x9gknd 13041 26 Ortho Ortho NNP cord-010119-t1x9gknd 13041 27 Clinical Clinical NNP cord-010119-t1x9gknd 13041 28 Diagnostics Diagnostics NNPS cord-010119-t1x9gknd 13041 29 . . . cord-010119-t1x9gknd 13042 1 Raritan Raritan NNP cord-010119-t1x9gknd 13042 2 , , , cord-010119-t1x9gknd 13042 3 NJ NJ NNP cord-010119-t1x9gknd 13042 4 ) ) -RRB- cord-010119-t1x9gknd 13042 5 for for IN cord-010119-t1x9gknd 13042 6 prenatal prenatal JJ cord-010119-t1x9gknd 13042 7 titration titration NN cord-010119-t1x9gknd 13042 8 studies study NNS cord-010119-t1x9gknd 13042 9 . . . cord-010119-t1x9gknd 13043 1 It -PRON- PRP cord-010119-t1x9gknd 13043 2 has have VBZ cord-010119-t1x9gknd 13043 3 been be VBN cord-010119-t1x9gknd 13043 4 established establish VBN cord-010119-t1x9gknd 13043 5 from from IN cord-010119-t1x9gknd 13043 6 previous previous JJ cord-010119-t1x9gknd 13043 7 publications publication NNS cord-010119-t1x9gknd 13043 8 that that IN cord-010119-t1x9gknd 13043 9 the the DT cord-010119-t1x9gknd 13043 10 micro micro JJ cord-010119-t1x9gknd 13043 11 - - JJ cord-010119-t1x9gknd 13043 12 column column JJ cord-010119-t1x9gknd 13043 13 assay assay NN cord-010119-t1x9gknd 13043 14 , , , cord-010119-t1x9gknd 13043 15 of of IN cord-010119-t1x9gknd 13043 16 which which WDT cord-010119-t1x9gknd 13043 17 the the DT cord-010119-t1x9gknd 13043 18 VISION vision NN cord-010119-t1x9gknd 13043 19 is be VBZ cord-010119-t1x9gknd 13043 20 based base VBN cord-010119-t1x9gknd 13043 21 , , , cord-010119-t1x9gknd 13043 22 may may MD cord-010119-t1x9gknd 13043 23 lead lead VB cord-010119-t1x9gknd 13043 24 to to IN cord-010119-t1x9gknd 13043 25 higher high JJR cord-010119-t1x9gknd 13043 26 titer titer NN cord-010119-t1x9gknd 13043 27 results result NNS cord-010119-t1x9gknd 13043 28 compared compare VBN cord-010119-t1x9gknd 13043 29 to to IN cord-010119-t1x9gknd 13043 30 standard standard JJ cord-010119-t1x9gknd 13043 31 tube tube NN cord-010119-t1x9gknd 13043 32 titrations titration NNS cord-010119-t1x9gknd 13043 33 . . . cord-010119-t1x9gknd 13044 1 This this DT cord-010119-t1x9gknd 13044 2 study study NN cord-010119-t1x9gknd 13044 3 sought seek VBD cord-010119-t1x9gknd 13044 4 to to TO cord-010119-t1x9gknd 13044 5 evaluate evaluate VB cord-010119-t1x9gknd 13044 6 the the DT cord-010119-t1x9gknd 13044 7 transition transition NN cord-010119-t1x9gknd 13044 8 from from IN cord-010119-t1x9gknd 13044 9 manual manual JJ cord-010119-t1x9gknd 13044 10 to to IN cord-010119-t1x9gknd 13044 11 automated automate VBN cord-010119-t1x9gknd 13044 12 titer titer NN cord-010119-t1x9gknd 13044 13 studies study NNS cord-010119-t1x9gknd 13044 14 from from IN cord-010119-t1x9gknd 13044 15 a a DT cord-010119-t1x9gknd 13044 16 sensitivity sensitivity NN cord-010119-t1x9gknd 13044 17 as as RB cord-010119-t1x9gknd 13044 18 well well RB cord-010119-t1x9gknd 13044 19 as as IN cord-010119-t1x9gknd 13044 20 cost cost NN cord-010119-t1x9gknd 13044 21 perspective perspective NN cord-010119-t1x9gknd 13044 22 . . . cord-010119-t1x9gknd 13045 1 Study Study NNP cord-010119-t1x9gknd 13045 2 Design Design NNP cord-010119-t1x9gknd 13045 3 / / SYM cord-010119-t1x9gknd 13045 4 Method method NN cord-010119-t1x9gknd 13045 5 : : : cord-010119-t1x9gknd 13046 1 Twenty twenty CD cord-010119-t1x9gknd 13046 2 - - HYPH cord-010119-t1x9gknd 13046 3 three three CD cord-010119-t1x9gknd 13046 4 prenatal prenatal JJ cord-010119-t1x9gknd 13046 5 retention retention NN cord-010119-t1x9gknd 13046 6 plasma plasma NN cord-010119-t1x9gknd 13046 7 samples sample NNS cord-010119-t1x9gknd 13046 8 were be VBD cord-010119-t1x9gknd 13046 9 tested test VBN cord-010119-t1x9gknd 13046 10 as as IN cord-010119-t1x9gknd 13046 11 part part NN cord-010119-t1x9gknd 13046 12 of of IN cord-010119-t1x9gknd 13046 13 the the DT cord-010119-t1x9gknd 13046 14 evaluation evaluation NN cord-010119-t1x9gknd 13046 15 of of IN cord-010119-t1x9gknd 13046 16 titration titration NN cord-010119-t1x9gknd 13046 17 studies study NNS cord-010119-t1x9gknd 13046 18 of of IN cord-010119-t1x9gknd 13046 19 the the DT cord-010119-t1x9gknd 13046 20 VISION vision NN cord-010119-t1x9gknd 13046 21 . . . cord-010119-t1x9gknd 13047 1 The the DT cord-010119-t1x9gknd 13047 2 samples sample NNS cord-010119-t1x9gknd 13047 3 were be VBD cord-010119-t1x9gknd 13047 4 manually manually RB cord-010119-t1x9gknd 13047 5 tested test VBN cord-010119-t1x9gknd 13047 6 with with IN cord-010119-t1x9gknd 13047 7 a a DT cord-010119-t1x9gknd 13047 8 standard standard JJ cord-010119-t1x9gknd 13047 9 two two CD cord-010119-t1x9gknd 13047 10 - - HYPH cord-010119-t1x9gknd 13047 11 fold fold JJ cord-010119-t1x9gknd 13047 12 serial serial JJ cord-010119-t1x9gknd 13047 13 dilution dilution NN cord-010119-t1x9gknd 13047 14 . . . cord-010119-t1x9gknd 13048 1 The the DT cord-010119-t1x9gknd 13048 2 titer titer NN cord-010119-t1x9gknd 13048 3 was be VBD cord-010119-t1x9gknd 13048 4 reported report VBN cord-010119-t1x9gknd 13048 5 as as IN cord-010119-t1x9gknd 13048 6 the the DT cord-010119-t1x9gknd 13048 7 last last JJ cord-010119-t1x9gknd 13048 8 tube tube NN cord-010119-t1x9gknd 13048 9 to to TO cord-010119-t1x9gknd 13048 10 demonstrate demonstrate VB cord-010119-t1x9gknd 13048 11 a a DT cord-010119-t1x9gknd 13048 12 11 11 CD cord-010119-t1x9gknd 13048 13 reaction reaction NN cord-010119-t1x9gknd 13048 14 by by IN cord-010119-t1x9gknd 13048 15 macroscopic macroscopic JJ cord-010119-t1x9gknd 13048 16 observation observation NN cord-010119-t1x9gknd 13048 17 . . . cord-010119-t1x9gknd 13049 1 The the DT cord-010119-t1x9gknd 13049 2 titer titer NN cord-010119-t1x9gknd 13049 3 studies study NNS cord-010119-t1x9gknd 13049 4 were be VBD cord-010119-t1x9gknd 13049 5 then then RB cord-010119-t1x9gknd 13049 6 repeated repeat VBN cord-010119-t1x9gknd 13049 7 using use VBG cord-010119-t1x9gknd 13049 8 the the DT cord-010119-t1x9gknd 13049 9 VISION vision NN cord-010119-t1x9gknd 13049 10 . . . cord-010119-t1x9gknd 13050 1 The the DT cord-010119-t1x9gknd 13050 2 results result NNS cord-010119-t1x9gknd 13050 3 of of IN cord-010119-t1x9gknd 13050 4 the the DT cord-010119-t1x9gknd 13050 5 manual manual JJ cord-010119-t1x9gknd 13050 6 and and CC cord-010119-t1x9gknd 13050 7 automated automate VBN cord-010119-t1x9gknd 13050 8 processes process NNS cord-010119-t1x9gknd 13050 9 were be VBD cord-010119-t1x9gknd 13050 10 compared compare VBN cord-010119-t1x9gknd 13050 11 and and CC cord-010119-t1x9gknd 13050 12 categorized categorize VBN cord-010119-t1x9gknd 13050 13 as as IN cord-010119-t1x9gknd 13050 14 " " `` cord-010119-t1x9gknd 13050 15 < < XX cord-010119-t1x9gknd 13050 16 2 2 CD cord-010119-t1x9gknd 13050 17 grade grade NN cord-010119-t1x9gknd 13050 18 " " '' cord-010119-t1x9gknd 13050 19 or or CC cord-010119-t1x9gknd 13050 20 " " `` cord-010119-t1x9gknd 13050 21 > > SYM cord-010119-t1x9gknd 13050 22 2 2 CD cord-010119-t1x9gknd 13050 23 grade grade NN cord-010119-t1x9gknd 13050 24 " " '' cord-010119-t1x9gknd 13050 25 difference difference NN cord-010119-t1x9gknd 13050 26 between between IN cord-010119-t1x9gknd 13050 27 endpoints endpoint NNS cord-010119-t1x9gknd 13050 28 . . . cord-010119-t1x9gknd 13051 1 This this DT cord-010119-t1x9gknd 13051 2 analysis analysis NN cord-010119-t1x9gknd 13051 3 is be VBZ cord-010119-t1x9gknd 13051 4 similar similar JJ cord-010119-t1x9gknd 13051 5 to to IN cord-010119-t1x9gknd 13051 6 the the DT cord-010119-t1x9gknd 13051 7 acceptable acceptable JJ cord-010119-t1x9gknd 13051 8 ranges range NNS cord-010119-t1x9gknd 13051 9 used use VBN cord-010119-t1x9gknd 13051 10 for for IN cord-010119-t1x9gknd 13051 11 evaluating evaluate VBG cord-010119-t1x9gknd 13051 12 College College NNP cord-010119-t1x9gknd 13051 13 of of IN cord-010119-t1x9gknd 13051 14 American American NNP cord-010119-t1x9gknd 13051 15 Pathologists Pathologists NNPS cord-010119-t1x9gknd 13051 16 ( ( -LRB- cord-010119-t1x9gknd 13051 17 CAP CAP NNP cord-010119-t1x9gknd 13051 18 ) ) -RRB- cord-010119-t1x9gknd 13051 19 proficiency proficiency NN cord-010119-t1x9gknd 13051 20 survey survey NN cord-010119-t1x9gknd 13051 21 challenges challenge NNS cord-010119-t1x9gknd 13051 22 . . . cord-010119-t1x9gknd 13052 1 A a DT cord-010119-t1x9gknd 13052 2 cost cost NN cord-010119-t1x9gknd 13052 3 analysis analysis NN cord-010119-t1x9gknd 13052 4 was be VBD cord-010119-t1x9gknd 13052 5 completed complete VBN cord-010119-t1x9gknd 13052 6 based base VBN cord-010119-t1x9gknd 13052 7 on on IN cord-010119-t1x9gknd 13052 8 the the DT cord-010119-t1x9gknd 13052 9 direct direct JJ cord-010119-t1x9gknd 13052 10 and and CC cord-010119-t1x9gknd 13052 11 indirect indirect JJ cord-010119-t1x9gknd 13052 12 cost cost NN cord-010119-t1x9gknd 13052 13 for for IN cord-010119-t1x9gknd 13052 14 each each DT cord-010119-t1x9gknd 13052 15 method method NN cord-010119-t1x9gknd 13052 16 , , , cord-010119-t1x9gknd 13052 17 excluding exclude VBG cord-010119-t1x9gknd 13052 18 the the DT cord-010119-t1x9gknd 13052 19 cost cost NN cord-010119-t1x9gknd 13052 20 of of IN cord-010119-t1x9gknd 13052 21 an an DT cord-010119-t1x9gknd 13052 22 analyzer analyzer NN cord-010119-t1x9gknd 13052 23 . . . cord-010119-t1x9gknd 13053 1 Results/ Results/ . cord-010119-t1x9gknd 13054 1 Finding finding NN cord-010119-t1x9gknd 13054 2 : : : cord-010119-t1x9gknd 13055 1 Table table NN cord-010119-t1x9gknd 13055 2 1 1 CD cord-010119-t1x9gknd 13055 3 demonstrates demonstrate VBZ cord-010119-t1x9gknd 13055 4 a a DT cord-010119-t1x9gknd 13055 5 summary summary NN cord-010119-t1x9gknd 13055 6 of of IN cord-010119-t1x9gknd 13055 7 the the DT cord-010119-t1x9gknd 13055 8 samples sample NNS cord-010119-t1x9gknd 13055 9 tested test VBN cord-010119-t1x9gknd 13055 10 by by IN cord-010119-t1x9gknd 13055 11 manual manual NNP cord-010119-t1x9gknd 13055 12 titer titer NNP cord-010119-t1x9gknd 13055 13 study study NN cord-010119-t1x9gknd 13055 14 and and CC cord-010119-t1x9gknd 13055 15 VISION vision NN cord-010119-t1x9gknd 13055 16 titration titration NN cord-010119-t1x9gknd 13055 17 method method NN cord-010119-t1x9gknd 13055 18 . . . cord-010119-t1x9gknd 13056 1 The the DT cord-010119-t1x9gknd 13056 2 VISION vision NN cord-010119-t1x9gknd 13056 3 titer titer NN cord-010119-t1x9gknd 13056 4 results result NNS cord-010119-t1x9gknd 13056 5 ( ( -LRB- cord-010119-t1x9gknd 13056 6 mean mean JJ cord-010119-t1x9gknd 13056 7 , , , cord-010119-t1x9gknd 13056 8 median median NN cord-010119-t1x9gknd 13056 9 , , , cord-010119-t1x9gknd 13056 10 and and CC cord-010119-t1x9gknd 13056 11 mode mode NN cord-010119-t1x9gknd 13056 12 ) ) -RRB- cord-010119-t1x9gknd 13056 13 were be VBD cord-010119-t1x9gknd 13056 14 higher high JJR cord-010119-t1x9gknd 13056 15 than than IN cord-010119-t1x9gknd 13056 16 the the DT cord-010119-t1x9gknd 13056 17 manual manual JJ cord-010119-t1x9gknd 13056 18 tube tube NN cord-010119-t1x9gknd 13056 19 titer titer NN cord-010119-t1x9gknd 13056 20 results result NNS cord-010119-t1x9gknd 13056 21 . . . cord-010119-t1x9gknd 13057 1 Less Less JJR cord-010119-t1x9gknd 13057 2 than than IN cord-010119-t1x9gknd 13057 3 half half NN cord-010119-t1x9gknd 13057 4 of of IN cord-010119-t1x9gknd 13057 5 the the DT cord-010119-t1x9gknd 13057 6 samples sample NNS cord-010119-t1x9gknd 13057 7 ( ( -LRB- cord-010119-t1x9gknd 13057 8 48 48 CD cord-010119-t1x9gknd 13057 9 % % NN cord-010119-t1x9gknd 13057 10 ) ) -RRB- cord-010119-t1x9gknd 13057 11 were be VBD cord-010119-t1x9gknd 13057 12 > > NFP cord-010119-t1x9gknd 13057 13 2 2 CD cord-010119-t1x9gknd 13057 14 titer titer NN cord-010119-t1x9gknd 13057 15 results result NNS cord-010119-t1x9gknd 13057 16 higher high JJR cord-010119-t1x9gknd 13057 17 , , , cord-010119-t1x9gknd 13057 18 while while IN cord-010119-t1x9gknd 13057 19 the the DT cord-010119-t1x9gknd 13057 20 majority majority NN cord-010119-t1x9gknd 13057 21 was be VBD cord-010119-t1x9gknd 13057 22 2 2 CD cord-010119-t1x9gknd 13057 23 titer titer NN cord-010119-t1x9gknd 13057 24 results result NNS cord-010119-t1x9gknd 13057 25 different different JJ cord-010119-t1x9gknd 13057 26 ( ( -LRB- cord-010119-t1x9gknd 13057 27 52 52 CD cord-010119-t1x9gknd 13057 28 % % NN cord-010119-t1x9gknd 13057 29 ) ) -RRB- cord-010119-t1x9gknd 13057 30 . . . cord-010119-t1x9gknd 13058 1 The the DT cord-010119-t1x9gknd 13058 2 cost cost NN cord-010119-t1x9gknd 13058 3 analysis analysis NN cord-010119-t1x9gknd 13058 4 is be VBZ cord-010119-t1x9gknd 13058 5 summarized summarize VBN cord-010119-t1x9gknd 13058 6 in in IN cord-010119-t1x9gknd 13058 7 Table Table NNP cord-010119-t1x9gknd 13058 8 2 2 CD cord-010119-t1x9gknd 13058 9 . . . cord-010119-t1x9gknd 13059 1 The the DT cord-010119-t1x9gknd 13059 2 indirect indirect JJ cord-010119-t1x9gknd 13059 3 cost cost NN cord-010119-t1x9gknd 13059 4 ( ( -LRB- cord-010119-t1x9gknd 13059 5 labor labor NN cord-010119-t1x9gknd 13059 6 ) ) -RRB- cord-010119-t1x9gknd 13059 7 was be VBD cord-010119-t1x9gknd 13059 8 significantly significantly RB cord-010119-t1x9gknd 13059 9 lower low JJR cord-010119-t1x9gknd 13059 10 with with IN cord-010119-t1x9gknd 13059 11 the the DT cord-010119-t1x9gknd 13059 12 use use NN cord-010119-t1x9gknd 13059 13 of of IN cord-010119-t1x9gknd 13059 14 the the DT cord-010119-t1x9gknd 13059 15 VISION vision NN cord-010119-t1x9gknd 13059 16 . . . cord-010119-t1x9gknd 13060 1 The the DT cord-010119-t1x9gknd 13060 2 reduction reduction NN cord-010119-t1x9gknd 13060 3 in in IN cord-010119-t1x9gknd 13060 4 pre pre JJ cord-010119-t1x9gknd 13060 5 - - JJ cord-010119-t1x9gknd 13060 6 analytical analytical JJ cord-010119-t1x9gknd 13060 7 technical technical JJ cord-010119-t1x9gknd 13060 8 time time NN cord-010119-t1x9gknd 13060 9 for for IN cord-010119-t1x9gknd 13060 10 manual manual JJ cord-010119-t1x9gknd 13060 11 preparation preparation NN cord-010119-t1x9gknd 13060 12 of of IN cord-010119-t1x9gknd 13060 13 the the DT cord-010119-t1x9gknd 13060 14 titration titration NN cord-010119-t1x9gknd 13060 15 is be VBZ cord-010119-t1x9gknd 13060 16 eliminated eliminate VBN cord-010119-t1x9gknd 13060 17 with with IN cord-010119-t1x9gknd 13060 18 the the DT cord-010119-t1x9gknd 13060 19 VISION vision NN cord-010119-t1x9gknd 13060 20 completing complete VBG cord-010119-t1x9gknd 13060 21 the the DT cord-010119-t1x9gknd 13060 22 titration titration NN cord-010119-t1x9gknd 13060 23 as as IN cord-010119-t1x9gknd 13060 24 part part NN cord-010119-t1x9gknd 13060 25 of of IN cord-010119-t1x9gknd 13060 26 the the DT cord-010119-t1x9gknd 13060 27 profile profile NN cord-010119-t1x9gknd 13060 28 of of IN cord-010119-t1x9gknd 13060 29 the the DT cord-010119-t1x9gknd 13060 30 titer titer NN cord-010119-t1x9gknd 13060 31 study study NN cord-010119-t1x9gknd 13060 32 of of IN cord-010119-t1x9gknd 13060 33 the the DT cord-010119-t1x9gknd 13060 34 analyzer analyzer NN cord-010119-t1x9gknd 13060 35 . . . cord-010119-t1x9gknd 13061 1 Conclusion conclusion NN cord-010119-t1x9gknd 13061 2 : : : cord-010119-t1x9gknd 13061 3 With with IN cord-010119-t1x9gknd 13061 4 an an DT cord-010119-t1x9gknd 13061 5 estimated estimate VBN cord-010119-t1x9gknd 13061 6 41 41 CD cord-010119-t1x9gknd 13061 7 % % NN cord-010119-t1x9gknd 13061 8 decrease decrease NN cord-010119-t1x9gknd 13061 9 in in IN cord-010119-t1x9gknd 13061 10 the the DT cord-010119-t1x9gknd 13061 11 cost cost NN cord-010119-t1x9gknd 13061 12 of of IN cord-010119-t1x9gknd 13061 13 a a DT cord-010119-t1x9gknd 13061 14 VISION vision NN cord-010119-t1x9gknd 13061 15 titer titer NN cord-010119-t1x9gknd 13061 16 compared compare VBN cord-010119-t1x9gknd 13061 17 to to IN cord-010119-t1x9gknd 13061 18 manual manual JJ cord-010119-t1x9gknd 13061 19 tube tube NN cord-010119-t1x9gknd 13061 20 method method NN cord-010119-t1x9gknd 13061 21 , , , cord-010119-t1x9gknd 13061 22 the the DT cord-010119-t1x9gknd 13061 23 change change NN cord-010119-t1x9gknd 13061 24 in in IN cord-010119-t1x9gknd 13061 25 practice practice NN cord-010119-t1x9gknd 13061 26 would would MD cord-010119-t1x9gknd 13061 27 clearly clearly RB cord-010119-t1x9gknd 13061 28 be be VB cord-010119-t1x9gknd 13061 29 a a DT cord-010119-t1x9gknd 13061 30 cost cost NN cord-010119-t1x9gknd 13061 31 and and CC cord-010119-t1x9gknd 13061 32 efficiency efficiency NN cord-010119-t1x9gknd 13061 33 measure measure NN cord-010119-t1x9gknd 13061 34 in in IN cord-010119-t1x9gknd 13061 35 the the DT cord-010119-t1x9gknd 13061 36 blood blood NN cord-010119-t1x9gknd 13061 37 bank bank NN cord-010119-t1x9gknd 13061 38 . . . cord-010119-t1x9gknd 13062 1 However however RB cord-010119-t1x9gknd 13062 2 , , , cord-010119-t1x9gknd 13062 3 the the DT cord-010119-t1x9gknd 13062 4 VISION vision NN cord-010119-t1x9gknd 13062 5 demonstrated demonstrate VBD cord-010119-t1x9gknd 13062 6 the the DT cord-010119-t1x9gknd 13062 7 expected expect VBN cord-010119-t1x9gknd 13062 8 increase increase NN cord-010119-t1x9gknd 13062 9 in in IN cord-010119-t1x9gknd 13062 10 titer titer NN cord-010119-t1x9gknd 13062 11 results result NNS cord-010119-t1x9gknd 13062 12 compared compare VBN cord-010119-t1x9gknd 13062 13 to to IN cord-010119-t1x9gknd 13062 14 manual manual JJ cord-010119-t1x9gknd 13062 15 tube tube NN cord-010119-t1x9gknd 13062 16 titer titer NN cord-010119-t1x9gknd 13062 17 results result NNS cord-010119-t1x9gknd 13062 18 . . . cord-010119-t1x9gknd 13063 1 This this DT cord-010119-t1x9gknd 13063 2 would would MD cord-010119-t1x9gknd 13063 3 impact impact VB cord-010119-t1x9gknd 13063 4 the the DT cord-010119-t1x9gknd 13063 5 critical critical JJ cord-010119-t1x9gknd 13063 6 values value NNS cord-010119-t1x9gknd 13063 7 currently currently RB cord-010119-t1x9gknd 13063 8 utilized utilize VBN cord-010119-t1x9gknd 13063 9 . . . cord-010119-t1x9gknd 13064 1 An an DT cord-010119-t1x9gknd 13064 2 impact impact NN cord-010119-t1x9gknd 13064 3 assessment assessment NN cord-010119-t1x9gknd 13064 4 for for IN cord-010119-t1x9gknd 13064 5 clinical clinical JJ cord-010119-t1x9gknd 13064 6 staff staff NN cord-010119-t1x9gknd 13064 7 would would MD cord-010119-t1x9gknd 13064 8 be be VB cord-010119-t1x9gknd 13064 9 necessary necessary JJ cord-010119-t1x9gknd 13064 10 to to TO cord-010119-t1x9gknd 13064 11 adequately adequately RB cord-010119-t1x9gknd 13064 12 implement implement VB cord-010119-t1x9gknd 13064 13 the the DT cord-010119-t1x9gknd 13064 14 change change NN cord-010119-t1x9gknd 13064 15 in in IN cord-010119-t1x9gknd 13064 16 method method NN cord-010119-t1x9gknd 13064 17 . . . cord-010119-t1x9gknd 13065 1 Consideration consideration NN cord-010119-t1x9gknd 13065 2 must must MD cord-010119-t1x9gknd 13065 3 be be VB cord-010119-t1x9gknd 13065 4 given give VBN cord-010119-t1x9gknd 13065 5 to to IN cord-010119-t1x9gknd 13065 6 changes change NNS cord-010119-t1x9gknd 13065 7 in in IN cord-010119-t1x9gknd 13065 8 the the DT cord-010119-t1x9gknd 13065 9 computer computer NN cord-010119-t1x9gknd 13065 10 logic logic NN cord-010119-t1x9gknd 13065 11 for for IN cord-010119-t1x9gknd 13065 12 critical critical JJ cord-010119-t1x9gknd 13065 13 values value NNS cord-010119-t1x9gknd 13065 14 on on IN cord-010119-t1x9gknd 13065 15 titer titer NN cord-010119-t1x9gknd 13065 16 studies study NNS cord-010119-t1x9gknd 13065 17 and and CC cord-010119-t1x9gknd 13065 18 training training NN cord-010119-t1x9gknd 13065 19 of of IN cord-010119-t1x9gknd 13065 20 physician physician NN cord-010119-t1x9gknd 13065 21 and and CC cord-010119-t1x9gknd 13065 22 nurse nurse NN cord-010119-t1x9gknd 13065 23 obstetric obstetric JJ cord-010119-t1x9gknd 13065 24 practitioners practitioner NNS cord-010119-t1x9gknd 13065 25 for for IN cord-010119-t1x9gknd 13065 26 changes change NNS cord-010119-t1x9gknd 13065 27 in in IN cord-010119-t1x9gknd 13065 28 the the DT cord-010119-t1x9gknd 13065 29 critical critical JJ cord-010119-t1x9gknd 13065 30 values value NNS cord-010119-t1x9gknd 13065 31 . . . cord-010119-t1x9gknd 13066 1 In in IN cord-010119-t1x9gknd 13066 2 addition addition NN cord-010119-t1x9gknd 13066 3 , , , cord-010119-t1x9gknd 13066 4 as as IN cord-010119-t1x9gknd 13066 5 part part NN cord-010119-t1x9gknd 13066 6 of of IN cord-010119-t1x9gknd 13066 7 changing change VBG cord-010119-t1x9gknd 13066 8 to to IN cord-010119-t1x9gknd 13066 9 the the DT cord-010119-t1x9gknd 13066 10 VISION vision NN cord-010119-t1x9gknd 13066 11 an an DT cord-010119-t1x9gknd 13066 12 implementation implementation NN cord-010119-t1x9gknd 13066 13 period period NN cord-010119-t1x9gknd 13066 14 will will MD cord-010119-t1x9gknd 13066 15 be be VB cord-010119-t1x9gknd 13066 16 necessary necessary JJ cord-010119-t1x9gknd 13066 17 to to TO cord-010119-t1x9gknd 13066 18 ensure ensure VB cord-010119-t1x9gknd 13066 19 that that IN cord-010119-t1x9gknd 13066 20 manual manual JJ cord-010119-t1x9gknd 13066 21 titers titer NNS cord-010119-t1x9gknd 13066 22 are be VBP cord-010119-t1x9gknd 13066 23 compared compare VBN cord-010119-t1x9gknd 13066 24 to to IN cord-010119-t1x9gknd 13066 25 previous previous JJ cord-010119-t1x9gknd 13066 26 manual manual JJ cord-010119-t1x9gknd 13066 27 titers titer NNS cord-010119-t1x9gknd 13066 28 and and CC cord-010119-t1x9gknd 13066 29 not not RB cord-010119-t1x9gknd 13066 30 to to IN cord-010119-t1x9gknd 13066 31 VISION vision NN cord-010119-t1x9gknd 13066 32 titer titer NN cord-010119-t1x9gknd 13066 33 results result NNS cord-010119-t1x9gknd 13066 34 which which WDT cord-010119-t1x9gknd 13066 35 would would MD cord-010119-t1x9gknd 13066 36 be be VB cord-010119-t1x9gknd 13066 37 higher high JJR cord-010119-t1x9gknd 13066 38 and and CC cord-010119-t1x9gknd 13066 39 may may MD cord-010119-t1x9gknd 13066 40 be be VB cord-010119-t1x9gknd 13066 41 interpreted interpret VBN cord-010119-t1x9gknd 13066 42 as as IN cord-010119-t1x9gknd 13066 43 a a DT cord-010119-t1x9gknd 13066 44 significant significant JJ cord-010119-t1x9gknd 13066 45 change change NN cord-010119-t1x9gknd 13066 46 for for IN cord-010119-t1x9gknd 13066 47 clinical clinical JJ cord-010119-t1x9gknd 13066 48 care care NN cord-010119-t1x9gknd 13066 49 of of IN cord-010119-t1x9gknd 13066 50 the the DT cord-010119-t1x9gknd 13066 51 patient patient NN cord-010119-t1x9gknd 13066 52 . . . cord-010119-t1x9gknd 13067 1 What what WP cord-010119-t1x9gknd 13067 2 Is be VBZ cord-010119-t1x9gknd 13067 3 the the DT cord-010119-t1x9gknd 13067 4 Best good JJS cord-010119-t1x9gknd 13067 5 Practice practice NN cord-010119-t1x9gknd 13067 6 for for IN cord-010119-t1x9gknd 13067 7 Testing Testing NNP cord-010119-t1x9gknd 13067 8 Residual Residual NNP cord-010119-t1x9gknd 13067 9 White White NNP cord-010119-t1x9gknd 13067 10 Blood Blood NNP cord-010119-t1x9gknd 13067 11 Cells cell NNS cord-010119-t1x9gknd 13067 12 in in IN cord-010119-t1x9gknd 13067 13 Blood blood NN cord-010119-t1x9gknd 13067 14 Components Components NNP cord-010119-t1x9gknd 13067 15 for for IN cord-010119-t1x9gknd 13067 16 Monthly Monthly NNP cord-010119-t1x9gknd 13067 17 Routine Routine NNP cord-010119-t1x9gknd 13067 18 Quality Quality NNP cord-010119-t1x9gknd 13067 19 Control Control NNP cord-010119-t1x9gknd 13067 20 ? ? . cord-010119-t1x9gknd 13068 1 Janja Janja NNP cord-010119-t1x9gknd 13068 2 Pajk Pajk NNP cord-010119-t1x9gknd 13069 1 * * NFP cord-010119-t1x9gknd 13069 2 . . . cord-010119-t1x9gknd 13070 1 General General NNP cord-010119-t1x9gknd 13070 2 Hospital Hospital NNP cord-010119-t1x9gknd 13070 3 Celje Celje NNP cord-010119-t1x9gknd 13070 4 Background Background NNP cord-010119-t1x9gknd 13070 5 / / SYM cord-010119-t1x9gknd 13070 6 Case Case NNP cord-010119-t1x9gknd 13070 7 Studies Studies NNPS cord-010119-t1x9gknd 13071 1 : : : cord-010119-t1x9gknd 13071 2 We -PRON- PRP cord-010119-t1x9gknd 13071 3 wanted want VBD cord-010119-t1x9gknd 13071 4 to to TO cord-010119-t1x9gknd 13071 5 discover discover VB cord-010119-t1x9gknd 13071 6 what what WP cord-010119-t1x9gknd 13071 7 is be VBZ cord-010119-t1x9gknd 13071 8 the the DT cord-010119-t1x9gknd 13071 9 best good JJS cord-010119-t1x9gknd 13071 10 routine routine JJ cord-010119-t1x9gknd 13071 11 quality quality NN cord-010119-t1x9gknd 13071 12 control control NN cord-010119-t1x9gknd 13071 13 practice practice NN cord-010119-t1x9gknd 13071 14 for for IN cord-010119-t1x9gknd 13071 15 testing test VBG cord-010119-t1x9gknd 13071 16 residual residual JJ cord-010119-t1x9gknd 13071 17 white white JJ cord-010119-t1x9gknd 13071 18 blood blood NN cord-010119-t1x9gknd 13071 19 cells cell NNS cord-010119-t1x9gknd 13071 20 in in IN cord-010119-t1x9gknd 13071 21 blood blood NN cord-010119-t1x9gknd 13071 22 components component NNS cord-010119-t1x9gknd 13071 23 . . . cord-010119-t1x9gknd 13072 1 Our -PRON- PRP$ cord-010119-t1x9gknd 13072 2 aim aim NN cord-010119-t1x9gknd 13072 3 was be VBD cord-010119-t1x9gknd 13072 4 to to TO cord-010119-t1x9gknd 13072 5 validate validate VB cord-010119-t1x9gknd 13072 6 the the DT cord-010119-t1x9gknd 13072 7 Adam Adam NNP cord-010119-t1x9gknd 13072 8 device device NN cord-010119-t1x9gknd 13072 9 for for IN cord-010119-t1x9gknd 13072 10 counting count VBG cord-010119-t1x9gknd 13072 11 thne thne NNP cord-010119-t1x9gknd 13072 12 number number NN cord-010119-t1x9gknd 13072 13 of of IN cord-010119-t1x9gknd 13072 14 residual residual JJ cord-010119-t1x9gknd 13072 15 white white JJ cord-010119-t1x9gknd 13072 16 blood blood NN cord-010119-t1x9gknd 13072 17 cells cell NNS cord-010119-t1x9gknd 13072 18 ( ( -LRB- cord-010119-t1x9gknd 13072 19 WBC WBC NNP cord-010119-t1x9gknd 13072 20 ) ) -RRB- cord-010119-t1x9gknd 13072 21 in in IN cord-010119-t1x9gknd 13072 22 leucocyte leucocyte NNP cord-010119-t1x9gknd 13072 23 depleted deplete VBN cord-010119-t1x9gknd 13072 24 and and CC cord-010119-t1x9gknd 13072 25 in in IN cord-010119-t1x9gknd 13072 26 non non JJ cord-010119-t1x9gknd 13072 27 - - JJ cord-010119-t1x9gknd 13072 28 leucocyte leucocyte RB cord-010119-t1x9gknd 13072 29 depleted deplete VBN cord-010119-t1x9gknd 13072 30 blood blood NN cord-010119-t1x9gknd 13072 31 components component NNS cord-010119-t1x9gknd 13072 32 ( ( -LRB- cord-010119-t1x9gknd 13072 33 BC BC NNP cord-010119-t1x9gknd 13072 34 ) ) -RRB- cord-010119-t1x9gknd 13072 35 and and CC cord-010119-t1x9gknd 13072 36 to to TO cord-010119-t1x9gknd 13072 37 compare compare VB cord-010119-t1x9gknd 13072 38 with with IN cord-010119-t1x9gknd 13072 39 standard standard JJ cord-010119-t1x9gknd 13072 40 counting counting NN cord-010119-t1x9gknd 13072 41 method method NN cord-010119-t1x9gknd 13072 42 by by IN cord-010119-t1x9gknd 13072 43 microscopy microscopy NNS cord-010119-t1x9gknd 13072 44 in in IN cord-010119-t1x9gknd 13072 45 Fuchs Fuchs NNP cord-010119-t1x9gknd 13072 46 Rosenthal Rosenthal NNP cord-010119-t1x9gknd 13072 47 chamber chamber NN cord-010119-t1x9gknd 13072 48 ( ( -LRB- cord-010119-t1x9gknd 13072 49 FRC FRC NNP cord-010119-t1x9gknd 13072 50 ) ) -RRB- cord-010119-t1x9gknd 13072 51 used use VBD cord-010119-t1x9gknd 13072 52 in in IN cord-010119-t1x9gknd 13072 53 GHC GHC NNP cord-010119-t1x9gknd 13072 54 and and CC cord-010119-t1x9gknd 13072 55 with with IN cord-010119-t1x9gknd 13072 56 Flow flow NN cord-010119-t1x9gknd 13072 57 cytometry cytometry NN cord-010119-t1x9gknd 13072 58 ( ( -LRB- cord-010119-t1x9gknd 13072 59 FC FC NNP cord-010119-t1x9gknd 13072 60 ) ) -RRB- cord-010119-t1x9gknd 13072 61 . . . cord-010119-t1x9gknd 13073 1 Study Study NNP cord-010119-t1x9gknd 13073 2 Design Design NNP cord-010119-t1x9gknd 13073 3 / / SYM cord-010119-t1x9gknd 13073 4 Method method NN cord-010119-t1x9gknd 13073 5 : : : cord-010119-t1x9gknd 13073 6 After after IN cord-010119-t1x9gknd 13073 7 23 23 CD cord-010119-t1x9gknd 13073 8 samples sample NNS cord-010119-t1x9gknd 13073 9 of of IN cord-010119-t1x9gknd 13073 10 red red JJ cord-010119-t1x9gknd 13073 11 blood blood NN cord-010119-t1x9gknd 13073 12 cells cell NNS cord-010119-t1x9gknd 13073 13 ( ( -LRB- cord-010119-t1x9gknd 13073 14 RBC RBC NNP cord-010119-t1x9gknd 13073 15 ) ) -RRB- cord-010119-t1x9gknd 13073 16 , , , cord-010119-t1x9gknd 13073 17 platelets platelet NNS cord-010119-t1x9gknd 13073 18 ( ( -LRB- cord-010119-t1x9gknd 13073 19 PLT PLT NNP cord-010119-t1x9gknd 13073 20 ) ) -RRB- cord-010119-t1x9gknd 13073 21 and and CC cord-010119-t1x9gknd 13073 22 fresh fresh JJ cord-010119-t1x9gknd 13073 23 frozen frozen JJ cord-010119-t1x9gknd 13073 24 plasma plasma NN cord-010119-t1x9gknd 13073 25 ( ( -LRB- cord-010119-t1x9gknd 13073 26 FFP FFP NNP cord-010119-t1x9gknd 13073 27 ) ) -RRB- cord-010119-t1x9gknd 13073 28 ( ( -LRB- cord-010119-t1x9gknd 13073 29 leucocyte leucocyte NNP cord-010119-t1x9gknd 13073 30 depleted deplete VBN cord-010119-t1x9gknd 13073 31 in in IN cord-010119-t1x9gknd 13073 32 top top NN cord-010119-t1x9gknd 13073 33 and and CC cord-010119-t1x9gknd 13073 34 top top NN cord-010119-t1x9gknd 13073 35 ( ( -LRB- cord-010119-t1x9gknd 13073 36 T/ T/ NNP cord-010119-t1x9gknd 13073 37 T T NNP cord-010119-t1x9gknd 13073 38 ) ) -RRB- cord-010119-t1x9gknd 13073 39 bags bag NNS cord-010119-t1x9gknd 13073 40 and and CC cord-010119-t1x9gknd 13073 41 non non JJ cord-010119-t1x9gknd 13073 42 - - JJ cord-010119-t1x9gknd 13073 43 leucocyte leucocyte RB cord-010119-t1x9gknd 13073 44 depleted deplete VBN cord-010119-t1x9gknd 13073 45 in in IN cord-010119-t1x9gknd 13073 46 top top NN cord-010119-t1x9gknd 13073 47 and and CC cord-010119-t1x9gknd 13073 48 bottom bottom NN cord-010119-t1x9gknd 13074 1 ( ( -LRB- cord-010119-t1x9gknd 13074 2 T T NNP cord-010119-t1x9gknd 13074 3 / / SYM cord-010119-t1x9gknd 13074 4 B b NN cord-010119-t1x9gknd 13074 5 ) ) -RRB- cord-010119-t1x9gknd 13074 6 bags bag NNS cord-010119-t1x9gknd 13074 7 ) ) -RRB- cord-010119-t1x9gknd 13074 8 were be VBD cord-010119-t1x9gknd 13074 9 stained stain VBN cord-010119-t1x9gknd 13074 10 with with IN cord-010119-t1x9gknd 13074 11 propidium propidium NN cord-010119-t1x9gknd 13074 12 iodide iodide NN cord-010119-t1x9gknd 13074 13 ( ( -LRB- cord-010119-t1x9gknd 13074 14 PI PI NNP cord-010119-t1x9gknd 13074 15 ) ) -RRB- cord-010119-t1x9gknd 13074 16 on on IN cord-010119-t1x9gknd 13074 17 r r NN cord-010119-t1x9gknd 13074 18 - - HYPH cord-010119-t1x9gknd 13074 19 Slides slide NNS cord-010119-t1x9gknd 13074 20 ; ; : cord-010119-t1x9gknd 13074 21 Adam Adam NNP cord-010119-t1x9gknd 13074 22 -rWBC -rwbc DT cord-010119-t1x9gknd 13074 23 device device NN cord-010119-t1x9gknd 13074 24 was be VBD cord-010119-t1x9gknd 13074 25 messured messured JJ cord-010119-t1x9gknd 13074 26 fluorescent fluorescent JJ cord-010119-t1x9gknd 13074 27 images image NNS cord-010119-t1x9gknd 13074 28 of of IN cord-010119-t1x9gknd 13074 29 stained stain VBN cord-010119-t1x9gknd 13074 30 WBC WBC NNP cord-010119-t1x9gknd 13074 31 nucleus nucleus NN cord-010119-t1x9gknd 13074 32 . . . cord-010119-t1x9gknd 13075 1 Data datum NNS cord-010119-t1x9gknd 13075 2 were be VBD cord-010119-t1x9gknd 13075 3 analised analise VBN cord-010119-t1x9gknd 13075 4 by by IN cord-010119-t1x9gknd 13075 5 image image NN cord-010119-t1x9gknd 13075 6 analysis analysis NN cord-010119-t1x9gknd 13075 7 software software NN cord-010119-t1x9gknd 13075 8 and and CC cord-010119-t1x9gknd 13075 9 later later RB cord-010119-t1x9gknd 13075 10 compared compare VBN cord-010119-t1x9gknd 13075 11 with with IN cord-010119-t1x9gknd 13075 12 results result NNS cord-010119-t1x9gknd 13075 13 of of IN cord-010119-t1x9gknd 13075 14 testing testing NN cord-010119-t1x9gknd 13075 15 samples sample NNS cord-010119-t1x9gknd 13075 16 in in IN cord-010119-t1x9gknd 13075 17 FRC FRC NNP cord-010119-t1x9gknd 13075 18 by by IN cord-010119-t1x9gknd 13075 19 microscopy microscopy NNS cord-010119-t1x9gknd 13075 20 and and CC cord-010119-t1x9gknd 13075 21 with with IN cord-010119-t1x9gknd 13075 22 FC.15 FC.15 NNP cord-010119-t1x9gknd 13075 23 samples sample NNS cord-010119-t1x9gknd 13075 24 of of IN cord-010119-t1x9gknd 13075 25 BC BC NNP cord-010119-t1x9gknd 13075 26 were be VBD cord-010119-t1x9gknd 13075 27 microscopic microscopic JJ cord-010119-t1x9gknd 13075 28 tested test VBN cord-010119-t1x9gknd 13075 29 in in IN cord-010119-t1x9gknd 13075 30 FRC FRC NNP cord-010119-t1x9gknd 13075 31 at at IN cord-010119-t1x9gknd 13075 32 Department Department NNP cord-010119-t1x9gknd 13075 33 of of IN cord-010119-t1x9gknd 13075 34 laboratory laboratory NN cord-010119-t1x9gknd 13075 35 medicine medicine NN cord-010119-t1x9gknd 13075 36 in in IN cord-010119-t1x9gknd 13075 37 GHC GHC NNP cord-010119-t1x9gknd 13075 38 ; ; : cord-010119-t1x9gknd 13075 39 another another DT cord-010119-t1x9gknd 13075 40 8 8 CD cord-010119-t1x9gknd 13075 41 samples sample NNS cord-010119-t1x9gknd 13075 42 were be VBD cord-010119-t1x9gknd 13075 43 measured measure VBN cord-010119-t1x9gknd 13075 44 with with IN cord-010119-t1x9gknd 13075 45 FC FC NNP cord-010119-t1x9gknd 13075 46 in in IN cord-010119-t1x9gknd 13075 47 UCC UCC NNP cord-010119-t1x9gknd 13075 48 Maribor Maribor NNP cord-010119-t1x9gknd 13075 49 . . . cord-010119-t1x9gknd 13076 1 Results result NNS cord-010119-t1x9gknd 13076 2 / / SYM cord-010119-t1x9gknd 13076 3 Finding finding NN cord-010119-t1x9gknd 13076 4 : : : cord-010119-t1x9gknd 13076 5 15 15 CD cord-010119-t1x9gknd 13076 6 samples sample NNS cord-010119-t1x9gknd 13076 7 ( ( -LRB- cord-010119-t1x9gknd 13076 8 6 6 CD cord-010119-t1x9gknd 13076 9 RBC RBC NNP cord-010119-t1x9gknd 13076 10 , , , cord-010119-t1x9gknd 13076 11 3 3 CD cord-010119-t1x9gknd 13076 12 PLT PLT NNP cord-010119-t1x9gknd 13076 13 , , , cord-010119-t1x9gknd 13076 14 3 3 CD cord-010119-t1x9gknd 13076 15 FFP ffp NN cord-010119-t1x9gknd 13076 16 - - : cord-010119-t1x9gknd 13076 17 all all DT cord-010119-t1x9gknd 13076 18 leucocyte leucocyte RB cord-010119-t1x9gknd 13076 19 depleted deplete VBN cord-010119-t1x9gknd 13076 20 and and CC cord-010119-t1x9gknd 13076 21 3 3 CD cord-010119-t1x9gknd 13076 22 non non JJ cord-010119-t1x9gknd 13076 23 - - JJ cord-010119-t1x9gknd 13076 24 leucocyte leucocyte RB cord-010119-t1x9gknd 13076 25 depleted deplete VBN cord-010119-t1x9gknd 13076 26 FFP FFP NNP cord-010119-t1x9gknd 13076 27 ) ) -RRB- cord-010119-t1x9gknd 13076 28 were be VBD cord-010119-t1x9gknd 13076 29 tested test VBN cord-010119-t1x9gknd 13076 30 in in IN cord-010119-t1x9gknd 13076 31 triplicates triplicate NNS cord-010119-t1x9gknd 13076 32 on on IN cord-010119-t1x9gknd 13076 33 Adam Adam NNP cord-010119-t1x9gknd 13076 34 and and CC cord-010119-t1x9gknd 13076 35 with with IN cord-010119-t1x9gknd 13076 36 FRC FRC NNP cord-010119-t1x9gknd 13076 37 once once RB cord-010119-t1x9gknd 13076 38 . . . cord-010119-t1x9gknd 13077 1 Coefficient coefficient NN cord-010119-t1x9gknd 13077 2 of of IN cord-010119-t1x9gknd 13077 3 variation variation NN cord-010119-t1x9gknd 13077 4 of of IN cord-010119-t1x9gknd 13077 5 ( ( -LRB- cord-010119-t1x9gknd 13077 6 KV% KV% NNP cord-010119-t1x9gknd 13077 7 ) ) -RRB- cord-010119-t1x9gknd 13077 8 of of IN cord-010119-t1x9gknd 13077 9 samples sample NNS cord-010119-t1x9gknd 13077 10 measured measure VBN cord-010119-t1x9gknd 13077 11 on on IN cord-010119-t1x9gknd 13077 12 Adam Adam NNP cord-010119-t1x9gknd 13077 13 for for IN cord-010119-t1x9gknd 13077 14 leucocyte leucocyte RB cord-010119-t1x9gknd 13077 15 depleted deplete VBD cord-010119-t1x9gknd 13077 16 BC BC NNP cord-010119-t1x9gknd 13077 17 varied varied JJ cord-010119-t1x9gknd 13077 18 for for IN cord-010119-t1x9gknd 13077 19 : : : cord-010119-t1x9gknd 13077 20 RBC RBC NNP cord-010119-t1x9gknd 13077 21 from from IN cord-010119-t1x9gknd 13077 22 44,10 44,10 CD cord-010119-t1x9gknd 13077 23 -173,21 -173,21 : cord-010119-t1x9gknd 13077 24 ; ; : cord-010119-t1x9gknd 13077 25 PLT PLT NNP cord-010119-t1x9gknd 13077 26 from from IN cord-010119-t1x9gknd 13077 27 86,60 86,60 CD cord-010119-t1x9gknd 13077 28 -100,00 -100,00 : cord-010119-t1x9gknd 13077 29 ; ; : cord-010119-t1x9gknd 13077 30 FFP FFP NNP cord-010119-t1x9gknd 13077 31 from from IN cord-010119-t1x9gknd 13077 32 86,60 86,60 CD cord-010119-t1x9gknd 13077 33 -173,21 -173,21 NFP cord-010119-t1x9gknd 13077 34 ; ; : cord-010119-t1x9gknd 13077 35 and and CC cord-010119-t1x9gknd 13077 36 for for IN cord-010119-t1x9gknd 13077 37 non non JJ cord-010119-t1x9gknd 13077 38 - - JJ cord-010119-t1x9gknd 13077 39 leucocyte leucocyte RB cord-010119-t1x9gknd 13077 40 depleted deplete VBD cord-010119-t1x9gknd 13077 41 FFP FFP NNP cord-010119-t1x9gknd 13077 42 from from IN cord-010119-t1x9gknd 13077 43 0,69 0,69 CD cord-010119-t1x9gknd 13077 44 -8,85 -8,85 . cord-010119-t1x9gknd 13078 1 ( ( -LRB- cord-010119-t1x9gknd 13078 2 Table table NN cord-010119-t1x9gknd 13078 3 1 1 CD cord-010119-t1x9gknd 13078 4 ) ) -RRB- cord-010119-t1x9gknd 13078 5 . . . cord-010119-t1x9gknd 13079 1 8 8 CD cord-010119-t1x9gknd 13079 2 samples sample NNS cord-010119-t1x9gknd 13079 3 ( ( -LRB- cord-010119-t1x9gknd 13079 4 2 2 CD cord-010119-t1x9gknd 13079 5 RBC RBC NNP cord-010119-t1x9gknd 13079 6 , , , cord-010119-t1x9gknd 13079 7 2 2 CD cord-010119-t1x9gknd 13079 8 PLT PLT NNP cord-010119-t1x9gknd 13079 9 , , , cord-010119-t1x9gknd 13079 10 2 2 CD cord-010119-t1x9gknd 13079 11 FFP FFP NNP cord-010119-t1x9gknd 13079 12 -all -all HYPH cord-010119-t1x9gknd 13079 13 leucocyte leucocyte RB cord-010119-t1x9gknd 13079 14 depleted deplete VBD cord-010119-t1x9gknd 13079 15 and and CC cord-010119-t1x9gknd 13079 16 2 2 CD cord-010119-t1x9gknd 13079 17 nonleucocyte nonleucocyte NN cord-010119-t1x9gknd 13079 18 depleted deplete VBD cord-010119-t1x9gknd 13079 19 FFP FFP NNP cord-010119-t1x9gknd 13079 20 ) ) -RRB- cord-010119-t1x9gknd 13079 21 were be VBD cord-010119-t1x9gknd 13079 22 tested test VBN cord-010119-t1x9gknd 13079 23 in in IN cord-010119-t1x9gknd 13079 24 triplicates triplicate NNS cord-010119-t1x9gknd 13079 25 on on IN cord-010119-t1x9gknd 13079 26 Adam Adam NNP cord-010119-t1x9gknd 13079 27 and and CC cord-010119-t1x9gknd 13079 28 with with IN cord-010119-t1x9gknd 13079 29 FC FC NNP cord-010119-t1x9gknd 13079 30 once once RB cord-010119-t1x9gknd 13079 31 . . . cord-010119-t1x9gknd 13080 1 KV% KV% NNP cord-010119-t1x9gknd 13080 2 of of IN cord-010119-t1x9gknd 13080 3 samples sample NNS cord-010119-t1x9gknd 13080 4 measured measure VBN cord-010119-t1x9gknd 13080 5 on on IN cord-010119-t1x9gknd 13080 6 Adam Adam NNP cord-010119-t1x9gknd 13080 7 for for IN cord-010119-t1x9gknd 13080 8 leucocyte leucocyte RB cord-010119-t1x9gknd 13080 9 depleted deplete VBD cord-010119-t1x9gknd 13080 10 BC BC NNP cord-010119-t1x9gknd 13080 11 varied varied JJ cord-010119-t1x9gknd 13080 12 for for IN cord-010119-t1x9gknd 13080 13 : : : cord-010119-t1x9gknd 13080 14 RBC RBC NNP cord-010119-t1x9gknd 13080 15 from from IN cord-010119-t1x9gknd 13080 16 91 91 CD cord-010119-t1x9gknd 13080 17 , , , cord-010119-t1x9gknd 13080 18 56 56 CD cord-010119-t1x9gknd 13080 19 ; ; : cord-010119-t1x9gknd 13080 20 PLT PLT NNP cord-010119-t1x9gknd 13080 21 from from IN cord-010119-t1x9gknd 13080 22 78 78 CD cord-010119-t1x9gknd 13080 23 , , , cord-010119-t1x9gknd 13080 24 21 21 CD cord-010119-t1x9gknd 13080 25 , , , cord-010119-t1x9gknd 13080 26 FFP FFP NNP cord-010119-t1x9gknd 13080 27 from from IN cord-010119-t1x9gknd 13080 28 66 66 CD cord-010119-t1x9gknd 13080 29 , , , cord-010119-t1x9gknd 13080 30 21 21 CD cord-010119-t1x9gknd 13080 31 ; ; : cord-010119-t1x9gknd 13080 32 and and CC cord-010119-t1x9gknd 13080 33 for for IN cord-010119-t1x9gknd 13080 34 non non JJ cord-010119-t1x9gknd 13080 35 - - JJ cord-010119-t1x9gknd 13080 36 leucocyte leucocyte RB cord-010119-t1x9gknd 13080 37 depleted deplete VBD cord-010119-t1x9gknd 13080 38 FFP FFP NNP cord-010119-t1x9gknd 13080 39 from from IN cord-010119-t1x9gknd 13080 40 11,17 11,17 CD cord-010119-t1x9gknd 13080 41 -15,91 -15,91 . cord-010119-t1x9gknd 13081 1 ( ( -LRB- cord-010119-t1x9gknd 13081 2 Table table NN cord-010119-t1x9gknd 13081 3 2 2 CD cord-010119-t1x9gknd 13081 4 ) ) -RRB- cord-010119-t1x9gknd 13081 5 .High .High . cord-010119-t1x9gknd 13082 1 percentage percentage NN cord-010119-t1x9gknd 13082 2 of of IN cord-010119-t1x9gknd 13082 3 KV KV NNP cord-010119-t1x9gknd 13082 4 was be VBD cord-010119-t1x9gknd 13082 5 noticed notice VBN cord-010119-t1x9gknd 13082 6 in in IN cord-010119-t1x9gknd 13082 7 samples sample NNS cord-010119-t1x9gknd 13082 8 with with IN cord-010119-t1x9gknd 13082 9 low low JJ cord-010119-t1x9gknd 13082 10 numbers number NNS cord-010119-t1x9gknd 13082 11 of of IN cord-010119-t1x9gknd 13082 12 WBC WBC NNP cord-010119-t1x9gknd 13082 13 ( ( -LRB- cord-010119-t1x9gknd 13082 14 in in IN cord-010119-t1x9gknd 13082 15 leucocyte leucocyte RB cord-010119-t1x9gknd 13082 16 depleted deplete VBN cord-010119-t1x9gknd 13082 17 BC BC NNP cord-010119-t1x9gknd 13082 18 ; ; : cord-010119-t1x9gknd 13082 19 low low JJ cord-010119-t1x9gknd 13082 20 percentage percentage NN cord-010119-t1x9gknd 13082 21 of of IN cord-010119-t1x9gknd 13082 22 KV KV NNP cord-010119-t1x9gknd 13082 23 in in IN cord-010119-t1x9gknd 13082 24 non non JJ cord-010119-t1x9gknd 13082 25 - - JJ cord-010119-t1x9gknd 13082 26 leucocyte leucocyte RB cord-010119-t1x9gknd 13082 27 depleted deplete VBN cord-010119-t1x9gknd 13082 28 FFP FFP NNP cord-010119-t1x9gknd 13082 29 , , , cord-010119-t1x9gknd 13082 30 with with IN cord-010119-t1x9gknd 13082 31 higher high JJR cord-010119-t1x9gknd 13082 32 amount amount NN cord-010119-t1x9gknd 13082 33 of of IN cord-010119-t1x9gknd 13082 34 WBC WBC NNP cord-010119-t1x9gknd 13082 35 was be VBD cord-010119-t1x9gknd 13082 36 observed observe VBN cord-010119-t1x9gknd 13082 37 . . . cord-010119-t1x9gknd 13083 1 Conclusion conclusion NN cord-010119-t1x9gknd 13083 2 : : : cord-010119-t1x9gknd 13084 1 All all DT cord-010119-t1x9gknd 13084 2 samples sample NNS cord-010119-t1x9gknd 13084 3 tested test VBN cord-010119-t1x9gknd 13084 4 with with IN cord-010119-t1x9gknd 13084 5 Adam Adam NNP cord-010119-t1x9gknd 13084 6 met meet VBD cord-010119-t1x9gknd 13084 7 expected expect VBN cord-010119-t1x9gknd 13084 8 criteria criterion NNS cord-010119-t1x9gknd 13084 9 for for IN cord-010119-t1x9gknd 13084 10 WBC WBC NNP cord-010119-t1x9gknd 13084 11 in in IN cord-010119-t1x9gknd 13084 12 BC BC NNP cord-010119-t1x9gknd 13084 13 in in IN cord-010119-t1x9gknd 13084 14 European European NNP cord-010119-t1x9gknd 13084 15 Union Union NNP cord-010119-t1x9gknd 13084 16 ( ( -LRB- cord-010119-t1x9gknd 13084 17 less less JJR cord-010119-t1x9gknd 13084 18 than than IN cord-010119-t1x9gknd 13084 19 1x10 1x10 CD cord-010119-t1x9gknd 13084 20 9 9 CD cord-010119-t1x9gknd 13084 21 /unit /unit , cord-010119-t1x9gknd 13084 22 for for IN cord-010119-t1x9gknd 13084 23 leucocyte leucocyte NNP cord-010119-t1x9gknd 13084 24 depleted deplete VBN cord-010119-t1x9gknd 13084 25 or or CC cord-010119-t1x9gknd 13084 26 1x10 1x10 CD cord-010119-t1x9gknd 13084 27 6 6 CD cord-010119-t1x9gknd 13084 28 / / SYM cord-010119-t1x9gknd 13084 29 unit unit NN cord-010119-t1x9gknd 13084 30 for for IN cord-010119-t1x9gknd 13084 31 non non JJ cord-010119-t1x9gknd 13084 32 - - JJ cord-010119-t1x9gknd 13084 33 leucocyte leucocyte RB cord-010119-t1x9gknd 13084 34 depleted deplete VBN cord-010119-t1x9gknd 13084 35 ) ) -RRB- cord-010119-t1x9gknd 13084 36 and and CC cord-010119-t1x9gknd 13084 37 were be VBD cord-010119-t1x9gknd 13084 38 comparable comparable JJ cord-010119-t1x9gknd 13084 39 with with IN cord-010119-t1x9gknd 13084 40 those those DT cord-010119-t1x9gknd 13084 41 tested test VBN cord-010119-t1x9gknd 13084 42 with with IN cord-010119-t1x9gknd 13084 43 FC FC NNP cord-010119-t1x9gknd 13084 44 ; ; : cord-010119-t1x9gknd 13084 45 the the DT cord-010119-t1x9gknd 13084 46 correlation correlation NN cord-010119-t1x9gknd 13084 47 with with IN cord-010119-t1x9gknd 13084 48 microscopy microscopy NNS cord-010119-t1x9gknd 13084 49 in in IN cord-010119-t1x9gknd 13084 50 FRC FRC NNP cord-010119-t1x9gknd 13084 51 was be VBD cord-010119-t1x9gknd 13084 52 worse bad JJR cord-010119-t1x9gknd 13084 53 . . . cord-010119-t1x9gknd 13085 1 With with IN cord-010119-t1x9gknd 13085 2 use use NN cord-010119-t1x9gknd 13085 3 of of IN cord-010119-t1x9gknd 13085 4 disposable disposable JJ cord-010119-t1x9gknd 13085 5 r r NN cord-010119-t1x9gknd 13085 6 - - HYPH cord-010119-t1x9gknd 13085 7 slides slide NNS cord-010119-t1x9gknd 13085 8 , , , cord-010119-t1x9gknd 13085 9 the the DT cord-010119-t1x9gknd 13085 10 risk risk NN cord-010119-t1x9gknd 13085 11 of of IN cord-010119-t1x9gknd 13085 12 exposure exposure NN cord-010119-t1x9gknd 13085 13 to to IN cord-010119-t1x9gknd 13085 14 the the DT cord-010119-t1x9gknd 13085 15 potential potential JJ cord-010119-t1x9gknd 13085 16 hazardous hazardous JJ cord-010119-t1x9gknd 13085 17 blood blood NN cord-010119-t1x9gknd 13085 18 samples sample NNS cord-010119-t1x9gknd 13085 19 is be VBZ cord-010119-t1x9gknd 13085 20 grately grately RB cord-010119-t1x9gknd 13085 21 reduced reduce VBN cord-010119-t1x9gknd 13085 22 , , , cord-010119-t1x9gknd 13085 23 the the DT cord-010119-t1x9gknd 13085 24 method method NN cord-010119-t1x9gknd 13085 25 is be VBZ cord-010119-t1x9gknd 13085 26 more more RBR cord-010119-t1x9gknd 13085 27 precise precise JJ cord-010119-t1x9gknd 13085 28 and and CC cord-010119-t1x9gknd 13085 29 not not RB cord-010119-t1x9gknd 13085 30 time time NN cord-010119-t1x9gknd 13085 31 consuming consume VBG cord-010119-t1x9gknd 13085 32 . . . cord-010119-t1x9gknd 13086 1 From from IN cord-010119-t1x9gknd 13086 2 January January NNP cord-010119-t1x9gknd 13086 3 2017 2017 CD cord-010119-t1x9gknd 13086 4 we -PRON- PRP cord-010119-t1x9gknd 13086 5 changed change VBD cord-010119-t1x9gknd 13086 6 our -PRON- PRP$ cord-010119-t1x9gknd 13086 7 protocol protocol NN cord-010119-t1x9gknd 13086 8 for for IN cord-010119-t1x9gknd 13086 9 testing test VBG cord-010119-t1x9gknd 13086 10 residual residual JJ cord-010119-t1x9gknd 13086 11 WBC WBC NNP cord-010119-t1x9gknd 13086 12 in in IN cord-010119-t1x9gknd 13086 13 BC BC NNP cord-010119-t1x9gknd 13086 14 with with IN cord-010119-t1x9gknd 13086 15 Adam Adam NNP cord-010119-t1x9gknd 13086 16 device device NN cord-010119-t1x9gknd 13086 17 and and CC cord-010119-t1x9gknd 13086 18 we -PRON- PRP cord-010119-t1x9gknd 13086 19 advise advise VBP cord-010119-t1x9gknd 13086 20 it -PRON- PRP cord-010119-t1x9gknd 13086 21 as as IN cord-010119-t1x9gknd 13086 22 the the DT cord-010119-t1x9gknd 13086 23 best good JJS cord-010119-t1x9gknd 13086 24 practice practice NN cord-010119-t1x9gknd 13086 25 for for IN cord-010119-t1x9gknd 13086 26 monthly monthly JJ cord-010119-t1x9gknd 13086 27 routine routine JJ cord-010119-t1x9gknd 13086 28 quality quality NN cord-010119-t1x9gknd 13086 29 control control NN cord-010119-t1x9gknd 13086 30 . . . cord-010119-t1x9gknd 13086 31 _SP